bluuebunny/crossref_metadata_2025 huggingface dataset:
Cortico-Hippocampal Computational Modeling Using Quantum Neural Networks to Simulate Classical Conditioning Paradigms
Authors: Khalid Mustafa , Wu Jun , M. Ali Taghreed , Ameen Thaair , Moustafa Ahmed A. , Zhu Qiuguo , Xiong Rong
Published: July 2020

Most existing cortico-hippocampal computational models use different artificial neural network topologies. These conventional approaches, which simulate various biological paradigms, can get slow training and inadequate conditioned responses for two reasons: increases in the number of conditioned stimuli and in the complexity of the simulated biological paradigms in different phases. In this paper, a cortico-hippocampal computational quantum (CHCQ) model is proposed for modeling intact and lesioned systems. The CHCQ model is the first computational model that uses the quantum neural networks for simulating the biological paradigms. The model consists of two entangled quantum neural networks: an adaptive single-layer feedforward quantum neural network and an autoencoder quantum neural network. The CHCQ model adaptively updates all the weights of its quantum neural networks using quantum instar, outstar, and Widrow–Hoff learning algorithms. Our model successfully simulated several biological processes and maintained the output-conditioned responses quickly and efficiently. Moreover, the results were consistent with prior biological studies.
Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome
Authors: Bax Heather J. , Chauhan Jitesh , Stavraka Chara , Khiabany Atousa , Nakamura Mano , Pellizzari Giulia , Ilieva Kristina M. , Lombardi Sara , Gould Hannah J. , Corrigan Christopher J. , Till Stephen J. , Katugampola Sidath , Jones Paul S. , Barton Claire , Winship Anna , Ghosh Sharmistha , Montes Ana , Josephs Debra H. , Spicer James F. , Karagiannis Sophia N.
Published: July 2020

Basophils are involved in manifestations of hypersensitivity, however, the current understanding of their propensity for activation and their prognostic value in cancer patients remains unclear. As in healthy and atopic individuals, basophil populations were identified in blood from ovarian cancer patients (n = 53) with diverse tumor histologies and treatment histories. Ex vivo basophil activation was measured by CD63 expression using the basophil activation test (BAT). Irrespective of prior treatment, basophils could be activated by stimulation with IgE- (anti-FcεRI and anti-IgE) and non-IgE (fMLP) mediated triggers. Basophil activation was detected by ex vivo exposure to paclitaxel, but not to other anti-cancer therapies, in agreement with a clinical history of systemic hypersensitivity reactions to paclitaxel. Protein and gene expression analyses support the presence of basophils (CCR3, CD123, FcεRI) and activated basophils (CD63, CD203c, tryptase) in ovarian tumors. Greater numbers of circulating basophils, cells with greater capacity for ex vivo stimulation (n = 35), and gene signatures indicating the presence of activated basophils in tumors (n = 439) were each associated with improved survival in ovarian cancer. Circulating basophils in cancer patients respond to IgE- and non-IgE-mediated signals and could help identify hypersensitivity to therapeutic agents. Activated circulating and tumor-infiltrating basophils may be potential biomarkers in oncology.
Bivalent Inhibitor with Selectivity for Trimeric MMP-9 Amplifies Neutrophil Chemotaxis and Enables Functional Studies on MMP-9 Proteoforms
Authors: Nuti Elisa , Rossello Armando , Cuffaro Doretta , Camodeca Caterina , Van Bael Jens , van der Maat Dries , Martens Erik , Fiten Pierre , Pereira Rafaela Vaz Sousa , Ugarte-Berzal Estefania , Gouwy Mieke , Opdenakker Ghislain , Vandooren Jennifer
Published: July 2020

A fundamental part of the immune response to infection or injury is leukocyte migration. Matrix metalloproteinases (MMPs) are a class of secreted or cell-bound endopeptidases, implicated in every step of the process of inflammatory cell migration. Hence, specific inhibition of MMPs is an interesting approach to control inflammation. We evaluated the potential of a bivalent carboxylate inhibitor to selectively inhibit the trimeric proteoform of MMP-9 and compared this with a corresponding monovalent inhibitor. The bivalent inhibitor efficiently inhibited trimeric MMP-9 (IC50 = 0.1 nM), with at least 500-fold selectivity for MMP-9 trimers over monomers. Surprisingly, in a mouse model for chemotaxis, the bivalent inhibitor amplified leukocyte influxes towards lipopolysaccharide-induced inflammation. We verified by microscopic and flow cytometry analysis increased amounts of neutrophils. In a mouse model for endotoxin shock, mice treated with the bivalent inhibitor had significantly increased levels of MMP-9 in plasma and lungs, indicative for increased inflammation. In conclusion, we propose a new role for MMP-9 trimers in tempering excessive neutrophil migration. In addition, we have identified a small molecule inhibitor with a high selectivity for the trimeric proteoform of MMP-9, which will allow further research on the functions of MMP-9 proteoforms.
Advances in Tissue Engineering and Innovative Fabrication Techniques for 3-D-Structures: Translational Applications in Neurodegenerative Diseases
Authors: Rey Federica , Barzaghini Bianca , Nardini Alessandra , Bordoni Matteo , Zuccotti Gian Vincenzo , Cereda Cristina , Raimondi Manuela Teresa , Carelli Stephana
Published: July 2020

In the field of regenerative medicine applied to neurodegenerative diseases, one of the most important challenges is the obtainment of innovative scaffolds aimed at improving the development of new frontiers in stem-cell therapy. In recent years, additive manufacturing techniques have gained more and more relevance proving the great potential of the fabrication of precision 3-D scaffolds. In this review, recent advances in additive manufacturing techniques are presented and discussed, with an overview on stimulus-triggered approaches, such as 3-D Printing and laser-based techniques, and deposition-based approaches. Innovative 3-D bioprinting techniques, which allow the production of cell/molecule-laden scaffolds, are becoming a promising frontier in disease modelling and therapy. In this context, the specific biomaterial, stiffness, precise geometrical patterns, and structural properties are to be considered of great relevance for their subsequent translational applications. Moreover, this work reports numerous recent advances in neural diseases modelling and specifically focuses on pre-clinical and clinical translation for scaffolding technology in multiple neurodegenerative diseases.
Chemical Modulation of Mitochondria–Endoplasmic Reticulum Contact Sites
Authors: Magalhães Rebelo Ana Paula , Dal Bello Federica , Knedlik Tomas , Kaar Natasha , Volpin Fabio , Shin Sang Hun , Giacomello Marta
Published: July 2020

Contact sites between mitochondria and endoplasmic reticulum (ER) are points in which the two organelles are in close proximity. Due to their structural and functional complexity, their exploitation as pharmacological targets has never been considered so far. Notwithstanding, the number of compounds described to target proteins residing at these interfaces either directly or indirectly is rising. Here we provide original insight into mitochondria–ER contact sites (MERCs), with a comprehensive overview of the current MERCs pharmacology. Importantly, we discuss the considerable potential of MERCs to become a druggable target for the development of novel therapeutic strategies.
Luminescent Solar Concentrators from Waterborne Polymer Coatings
Authors: Minei Pierpaolo , Iasilli Giuseppe , Ruggeri Giacomo , Pucci Andrea
Published: July 2020

This study reports for the first time the use of waterborne polymers as host matrices for luminescent solar concentrators (LSCs). Notably, three types of waterborne polymer dispersions based either on acrylic acid esters and styrene (Polidisp® 7602), acrylic and methacrylic acid esters (Polidisp® 7788) or aliphatic polyester-based polyurethane (Tecfin P40) were selected as amorphous coatings over glass substrates. Water soluble Basic Yellow 40 (BY40) and Disperse Red 277 (DR277) were utilized as fluorophores and the derived thin polymer films (100 μm) were found homogeneous within the dye range of concentration investigated (0.3–2 wt.%). The optical efficiency determination (ηopt) evidenced LSCs performances close to those collected from benchmark polymethylmethacrylate (PMMA) thin films and Lumogen Red F350 (LR) with the same experimental setup. Noteworthy, maximum ηopt of 9.5 ± 0.2 were recorded for the Polidisp® 7602 matrix containing BY40, thus definitely supporting the waterborne polymer matrices for the development of high performance and cost-effective LSCs.
Enhancing Electrical and Thermal Properties of Al6061 Parts by Electrophoresis Deposition of Multi-Walled Carbon Nanotubes
Authors: Rodríguez-Salinas Juan , Hernández Marla B. , Cruz Luis Gerardo , Martínez-Romero Oscar , Ulloa-Castillo Nicolás A. , Elías-Zúñiga Alex
Published: July 2020

The present research work focuses on depositing multi-walled carbon nanotubes (MWCNTs) onto aluminum parts to modify their electrical and thermal properties by an electrodeposition process (EDP). This film coated over the sample surface creates a network of high conductive thin layer that promotes free electron flow and heat-loss reduction. Experimental measurements on the metallic surface part show an increment of the electrical conductivity of 9.6% for the sample coated with 0.05 mg/mL of MWCNTs with a heat dissipation increase of 36%.
Design, Synthesis, Crystal Structure, and Fungicidal Activity of Two Fenclorim Derivatives
Authors: Xiong Ke-Jie , Du Feng-Pei
Published: July 2020

Two fenclorim derivatives (compounds 6 and 7) were synthesized by linking active sub-structures using fenclorim as the lead compound. The chemical structures of the two compounds were confirmed by NMR spectroscopy, high resolution mass spectrometry, and X-ray diffraction analysis. Their fungicidal activity against six plant fungal strains was tested. Compounds 6 and 7 both crystallized in the monoclinic system, with a P21/c space group (a = 8.4842(6) Å, b = 24.457(2) Å, c = 8.9940(6) Å, V = 1855.0(2) Å3, Z = 4) and Cc space group (a = 10.2347(7) Å, b = 18.3224(10) Å, c = 7.2447(4) Å, V = 1357.50(14) Å3, Z = 4), respectively. The crystal structure of compound 6 was stabilized by C–H···N and C–H···O hydrogen bonding interactions and N–H···N hydrogen bonds linked the neighboring molecules of compound 7 to form a three-dimensional framework. Compound 6 displayed the most excellent activity, which is much better than that of pyrimethanil against Botrytis cinerea in vivo. Additionally, compound 6 exhibited greater in vitro activity against Pseudoperonospora cubensis compared to that of pyrimethanil. Moreover, compound 7 exhibited strong fungicidal activity against Erysiphe cichoracearum at 50 mg/L in vitro, while pyrimethanil did not. Compounds 6 and 7 could be used as new pyrimidine fungicides in the future.
EM-detwin: A Program for Resolving Indexing Ambiguity in Serial Crystallography Using the Expectation-Maximization Algorithm
Authors: Shi Yingchen , Liu Haiguang
Published: July 2020

Serial crystallography (SX), first used as an application of X-ray free-electron lasers (XFELs), is becoming a useful method to determine atomic-resolution structures of proteins from micrometer-sized crystals with bright X-ray sources. Because of unknown orientations of crystals in SX, indexing ambiguity issue arises when the symmetry of Bravais lattice is higher than the space group symmetry, making some diffraction signals wrongly merged to the total intensity in twinned orientations. In this research, we developed a program within the CrystFEL framework, the EM-detwin, to resolve this indexing ambiguity problem based on the expectation-maximization algorithm. Testing results on the performance of the EM-detwin have demonstrated its usefulness in correctly indexing diffraction data as a valuable tool for SX data analysis.
Synthesis of Metal Nanoparticles by Microorganisms
Authors: Kato Yugo , Suzuki Michio
Published: July 2020

Metal nanoparticles (NPs), with sizes ranging from 1–100 nm, are of great scientific interest because their functions and features differ greatly from those of bulk metal. Chemical or physical methods are used to synthesize commercial quantities of NPs, and green, energy-efficient approaches generating byproducts of low toxicity are desirable to minimize the environmental impact of the industrial methods. Some microorganisms synthesize metal NPs for detoxification and metabolic reasons at room temperature and pressure in aqueous solution. Metal NPs have been prepared via green methods by incubating microorganisms or cell-free extracts of microorganisms with dissolved metal ions for hours or days. Metal NPs are analyzed using various techniques, such as ultraviolet-visible spectroscopy, electron microscopy, X-ray diffraction, electron diffraction, energy-dispersive X-ray spectroscopy, and X-ray photoelectron spectroscopy. Numerous publications have focused on microorganisms that synthesize various metal NPs. For example, Ag, Au, CdS, CdSe, Cu, CuO, Gd2O3, Fe3O4, PbS, Pd, Sb2O3, TiO2, and ZrO2 NPs have been reported. Herein, we review the synthesis of metal NPs by microorganisms. Although the molecular mechanisms of their synthesis have been investigated to some extent, experimental evidence for the mechanisms is limited. Understanding the mechanisms is crucial for industrial-scale development of microorganism-synthesized metal NPs.
Tardigrades from Iztaccíhuatl Volcano (Trans-Mexican Volcanic Belt), with the Description of Minibiotus citlalium sp. nov. (Eutardigrada: Macrobiotidae)
Authors: Dueñas-Cedillo Alba , Martínez-Méndez Evelyn , García-Román Jazmín , Armendáriz-Toledano Francisco , Ruiz Enrico
Published: July 2020

The study of tardigrade diversity in Mexico is at early stage of development, to date, 56 extant species have been reported. To identify the tardigrade fauna associated with mosses in the Iztaccíhuatl volcano, we performed a systematic sampling along an altitudinal and multi-habitat gradient. A total of 57 moss samples were collected, 233 adults, 20 exuviae, and 40 free-laid tardigrade eggs were extracted from them. Five species were identified, and three putative species were determined. Diphascon mitrense and Minibiotus sidereus represents new records for Mexico and North America, while Adropion scoticum is a new record for Mexico. Additionally, one new species, Minibiotus citlalium sp. nov. was discovered; it resembles to Min. constellatus, Min. sidereus and Min. pentannulatus by the presence of a similar distribution pattern of star-shaped pores in the dorsal cuticle arranged in 11 transverse rows, which become double in the segments of the legs I–III, and by a very large star-shaped pore (5–6 tips) on each leg of the fourth pair. Minibiotus citlalium sp. nov. differs from other Minibiotus species mainly by macroplacoid length sequence, presence of both small and large star-shaped pores on the external surface on all legs, and by egg processes with inconspicuous ornamentation.
Influence of Tooth Factors and Procedural Errors on the Incidence and Severity of Post-Endodontic Pain: A Prospective Clinical Study
Authors: Bamini Lavanya , Sherwood Anand , Arias Ana , Subramani Savadamoorthi Kamatchi , Bhargavi Puridi
Published: July 2020

The objective of this prospective study was to assess tooth-related factors that play a role in the incidence of postoperative pain (PP) and determining if procedural errors influence PP occurrence. A total of 442 patients referred for root canal treatment met the inclusion criteria and were included in this prospective study. The same protocol was used in all root canal treatments. Patient, tooth, treatment related factors and the occurrence of procedural errors were registered. Incidence and intensity of PP was assessed at 24 and 48 h by telephonic interview and in person seven and 15 days after treatment. A logistic and ordinal regression analysis was used to assess the role of patient, tooth and treatment related factors in the incidence and intensity of PP, respectively. Preoperative and intraoperative factors differently affected the incidence of PP at the different time intervals. The presence of procedural errors did not significantly influence PP occurrence. The presence of preoperative pain and the need of additional anesthesia during treatment were associated with higher incidence of PP 24 and 48 h after treatment; the extent of apical enlargement played a significant role in the presence of PP after seven days of treatment; and the excessive occlusal load induced by the absence of a contralateral tooth was the only factor related to the maintenance of PP up to 15 days. In conclusion, the presence of preoperative pain, the need of additional anesthesia during treatment, the extent of apical enlargement and the excessive occlusal load induced by the absence of a contralateral tooth were related to a higher incidence of PP.
Research on Evaluating the Sustainable Operation of Rail Transit System Based on QFD and Fuzzy Clustering
Authors: Yan Bing , Yu Liying , Wang Jing
Published: July 2020

The purpose of this study is to evaluate the sustainable operation of rail transit system. In rail transit system, as the most important aspect of negative entropy flow, the effective strategy can offset the increasing entropy of the system and make it have the characteristics of dissipative structure, so as to realize the sustainable operation. At first, this study constructs the Pressure-State-Response (PSR) model to evaluate the sustainable operation of rail transit system. In this PSR model, “pressure” is viewed as customer requirements, which answers the reasons for such changes in rail transit system; “state” refers to the state and environment of system activities, which can be described as the challenges of coping with system pressure; “response” describes the system’s actions to address the challenges posed by customer needs, namely operational strategies. Moreover, then, 13 pressure indices, five state indices and 11 response indices are summarized. In addition, based on quality function deployment (QFD), with 13 pressure indices as input variables, five state indices as customer requirements (CRs) of QFD and 11 response indices as technical attributes (TAs) of QFD, this study proposed the three-phase evaluation method of the sustainable operation of rail transit system to obtain the operational strategy (that is, negative entropy flow): The first phase is to verify that 13 pressure indices can be clustered into five state indices by fuzzy clustering analysis; The second phase is to get the weights of five state indices by evidential reasoning; The third phase is to rate the importance of 11 response indices by integrating fuzzy weighted average and expected value operator. Finally, the proposed model and method of evaluation are applied to the empirical analysis of Shanghai rail transit system. Finally, we come to the conclusion that Shanghai rail transit system should take priority from the following five aspects: “advancement of design standards”, “reliability of subway facilities”, “completeness of operational rules”, “standardization of management operation” and “rationality of passenger flow control”.
Analysis of the Influence of Diesel Spray Injection on the Ignition and Soot Formation in Multiple Injection Strategy
Authors: Payri Raul , García-Oliver José M. , Mendoza Victor , Viera Alberto
Published: July 2020

Multiple injection strategies have increased their capabilities along with the evolution of injection system technologies up to the point that nowadays it is possible to inject eight different pulses, permitting to improve the engine performance, and consequently, emissions. The present work was realized for two simplified strategies: a pilot-main and a main-post, in order to analyze the influence of an auxiliary pulse on the main and otherwise, in reactive conditions for two pilot/post quantities and four hydraulic dwell times. The study was carried out by employing two optical techniques: diffused back-illumination with flame bandpass chemiluminescence for measuring soot, represented by soot-maps distribution, and single-pass schlieren for ignition delay (ID). Furthermore, a novel methodology for decoupling the start of combustion (SOC) of the second pulse was developed and successfully validated. From the ignition delay results, it was found for all test points that the pilot injection enhanced conditions, which promote a faster ignition of the main pulse, also at higher chamber temperatures, all conditions presented a separate combustion event for each injection. In emission terms, soot increased in the pilot-main strategies compared to its single injection case, as well as, in conditions that promote faster-premixed combustion.
Optimal Sizing of Fuel Cell Hybrid Power Sources with Reliability Consideration
Authors: Ceschia Adriano , Azib Toufik , Bethoux Olivier , Alves Francisco
Published: July 2020

This paper addresses the issue of optimal sizing reliability applied to a fuel cell/battery hybrid system. This specific problem raises the global problem of strong coupling between hardware and control parameters. To tackle this matter, the proposed methodology uses nested optimization loops. Furthermore, to increase the optimal design relevance, a reliability assessment of the optimal sizing set is introduced. This new paradigm enables showing the early impact of the reliability criteria on design choices regarding energetic performance index. It leads to a smart design methodology permitting to avoid complexity and save computing time. It considerably helps design engineers set up the best hybridization rate and enables practicing tradeoffs, including reliability aspects in the early design stages.
Decomposition Analysis of CO2 Emission from Electricity Generation: Comparison of OECD Countries before and after the Financial Crisis
Authors: Kim Haein , Kim Minsang , Kim Hyunggeun , Park Sangkyu
Published: July 2020

The purpose of this study is to analyze the factors that affect CO2 emissions in the electricity generation sector in 36 OECD countries during the periods 1995–2008 and 2008–2017. This paper utilized Logarithmic Mean Divisia Index method for decomposing CO2 emission into economic activity, electricity intensity that represents demand policy effort, the share of thermal generation, the mix of thermal generation, thermal efficiency that represent supply policy efforts, and carbon emission coefficient. The results showed that EU nations achieved a higher level of CO2 reduction compared to that of non-EU nations. Regarding the policy factors, the decrease in the share of thermal generation served as the key driver, followed by the decrease in electricity intensity via improvements in energy consumption efficiency. Most non-EU countries such as South Korea, Chile, Mexico, Turkey, and Japan demonstrated an increasing trend of carbon emission during this period, which could be attributed to the changes in the generation mix on the supply side or the electricity intensity on the demand side. Increase in electricity price was confirmed to cause lower electricity intensity. South Korea had the largest amount of carbon emission among OECD countries and maintained one of the lowest electricity retail prices among OECD countries.
Dynamic Simulation and Energy Economic Analysis of a Household Hybrid Ground-Solar-Wind System Using TRNSYS Software
Authors: Figaj Rafał , Żołądek Maciej , Goryl Wojciech
Published: July 2020

The adoption of micro-scale renewable energy systems in the residential sector has started to be increasingly diffused in recent years. Among the possible systems, ground heat exchangers coupled with reversible heat pumps are an interesting solution for providing space heating and cooling to households. In this context, a possible hybridization of this technology with other renewable sources may lead to significant benefits in terms of energy performance and reduction of the dependency on conventional energy sources. However, the investigation of hybrid systems is not frequently addressed in the literature. The present paper presents a technical, energy, and economic analysis of a hybrid ground-solar-wind system, proving space heating/cooling, domestic hot water, and electrical energy for a household. The system includes vertical ground heat exchangers, a water–water reversible heat pump, photovoltaic/thermal collectors, and a wind turbine. The system with the building is modeled and dynamically simulated in the Transient System Simulation (TRNSYS) software. Daily dynamic operation of the system and the monthly and yearly results are analyzed. In addition, a parametric analysis is performed varying the solar field area and wind turbine power. The yearly results point out that the hybrid system, compared to a conventional system with natural gas boiler and electrical chiller, allows one to reduce the consumption of primary energy of 66.6%, and the production of electrical energy matches 68.6% of the user demand on a yearly basis. On the other hand, the economic results show that that system is not competitive with the conventional solution, because the simple pay back period is 21.6 years, due to the cost of the system components.
Natural Regeneration Following Partial and Clear-Cut Harvesting in Mature Aspen-Jack Pine Stands in Eastern Canada
Authors: Maleki Kobra , Nguema Allogo Freddy , Lafleur Benoit
Published: July 2020

Over the last three decades, the ecological basis for the generalized use of even-aged silviculture in boreal forests has been increasingly challenged. In boreal mixed-wood landscapes, the diminishing proportion of conifers, to the benefit of intolerant hardwoods, has been a primary concern, coupled with the general rarefication of old-growth conifer-dominated stands. In this context, partial cutting, extended rotations and forest renewal techniques that eliminate or reduce regenerating hardwoods have been proposed as means of regaining greater conifer cover. As a result, experimentation and industrial application of various forms of both variable retention and partial harvesting are occurring across the commercial Canadian boreal forest. In this study, we compared the effects of two harvesting intensities, clearcutting and low-intensity partial cutting (removal of 25–31% of tree basal area), on hardwood and conifer regeneration levels 7–19 years following treatments in aspen (Populus tremuloides)-dominated stands and verified whether regeneration differences existed between micro-sites on and off machinery trails. The abundance of aspen regeneration increased with percent basal area removal and was positively correlated to the abundance of mature aspen prior to harvesting. The abundance of fir (Abies balsamea) regeneration after partial cutting was similar to controls and higher than after clear-cutting and was positively correlated with ground cover of mixed litter (i.e., mixture of needles and leaves) and negatively correlated with ground cover of broadleaf litter. These results suggest that it is possible in boreal mixed-woods to control aspen abundance and promote or maintain conifer regeneration through silvicultural treatments that limit canopy opening and promote mixed forest floor litter.
Characteristic Factors of Aspiration Pneumonia to Distinguish from Community-Acquired Pneumonia among Oldest-Old Patients in Primary-Care Settings of Japan
Authors: Manabe Toshie , Kotani Kazuhiko , Teraura Hiroyuki , Minami Kensuke , Kohro Takahide , Matsumura Masami
Published: July 2020

Background: Aspiration pneumonia (AsP), a phenotype of community-acquired pneumonia (CAP), is a common and problematic disease with symptomless recurrence and fatality in old adults. Characteristic factors for distinguishing AsP from CAP need to be determined to manage AsP. No such factorial markers in oldest-old adults, who are often seen in the primary-care settings, have yet been established. Methods: From the database of our Primary Care and General Practice Study, including the general backgrounds, clinical conditions and laboratory findings collected by primary care physicians and general practitioners, the records of 130 patients diagnosed with either AsP (n = 72) or CAP (n = 58) were extracted. Characteristic factors associated with the diagnosis of AsP were statistically compared between AsP and CAP. Results: The patients were older in the AsP group (median 90 years old) than in the CAP group (86 years old). The body temperature, heart rate, and diastolic blood pressure were lower in the patients with AsP than in those with CAP. Witnessed meal dysphagia by families and caregivers was reported only in AsP. Living in a nursing home, comorbidities of cerebral infarction and dementia (as positive factors) and hypertension (as a negative factor) were considered predictive to diagnose AsP in a stepwise logistic regression analysis. Conclusions: Among oldest-old adults in primary-care settings, living in a nursing home and the dysphagia risks are suggested to be characteristic factors for diagnosing AsP. Age and some relevant clinical information may help manage AsP and also be useful for families and caregivers.
Relationships between Controlling Interpersonal Coaching Style, Basic Psychological Need Thwarting, and Burnout, in Adolescent Soccer Players
Authors: Morales-Sánchez Verónica , Crespillo-Jurado Miriam , Jiménez-López David , Morillo-Baro Juan P. , Hernández-Mendo Antonio , Reigal Rafael E.
Published: July 2020

The aim of this paper is to analyze the relationships between a controlling interpersonal style, psychological need thwarting and burnout in adolescent soccer players and to test a structural equation model to analyze whether (a) a controlling interpersonal style is a predictor of psychological need thwarting and whether (b) psychological need thwarting is a predictor of burnout. A total of 103 male soccer players between the ages of 12 and 17 participated in the research (M = 14.91; SD = 5.56). The Controlling Coach Behaviors Scale, the Psychological Need Thwarting Scale, and the Athlete Burnout Questionnaire were used to evaluate the variables under study. The analyses revealed significant relationships between a controlling interpersonal style, psychological need thwarting and burnout. Furthermore, the proposed structural equations model, using the partial least squares (PLS) method, showed that a controlling style is a positive predictor of basic psychological need thwarting and that the latter is a predictor of burnout, as well as revealing an indirect relationship between a controlling style and burnout. This indirect effect of the controlling style variable on burnout can be enhanced (or attenuated) by the basic psychological need thwarting variable, which acts as a modulator.
Dispositional Optimism, Burnout and Their Relationship with Self-Reported Health Status among Nurses Working in Long-Term Healthcare Centers
Authors: Malagón-Aguilera Maria Carmen , Suñer-Soler Rosa , Bonmatí-Tomas Anna , Bosch-Farré Cristina , Gelabert-Viella Sandra , Fontova-Almató Aurora , Grau-Martín Armand , Juvinyà-Canal Dolors
Published: July 2020

The mental health of nurses working in long-term healthcare centers is affected by the care they provide to older people with major chronic diseases and comorbidity and this in turn affects the quality of that care. The aim of the study was to investigate dispositional optimism, burnout and self-reported health among nurses working in long-term healthcare centers. A descriptive, cross-sectional survey design was used. Survey questionnaires were distributed in 11 long-term health care centers (n = 156) in Catalonia (Spain). The instruments used were LOT-R (dispositional optimism), MBI (burnout) and EuroQol EQ-5D (self-reported health). Bivariate analyses and multivariate linear regression models were used. Self-reported health correlated directly with dispositional optimism and inversely with emotional exhaustion and cynicism. Better perceived health was independently associated with greater dispositional optimism and social support, lower levels of emotional exhaustion level and the absence of burnout. Dispositional optimism in nurses is associated with a greater perception of health and low levels of emotional exhaustion.
Dust Deposition Impacts at a Liquidated Gold Mine Village: Gauteng Province in South Africa
Authors: Mpanza Mbalenhle , Adam Elhadi , Moolla Raeesa
Published: July 2020

The windy season brings numerous community complaints for gold mining companies situated in the Witwatersrand due to windblown dust from partially rehabilitated tailings storage facilities (TSFs). For communities encroaching onto TSFs, windblown dust is perceived as a health hazard and an environmental challenge. In a study conducted in 2017 by the Lawyers for Human Rights, the community of a gold mine village perceived tailings storage facility 6 (TSF6) and other surrounding tailings storage facilities which are partially rehabilitated to be a health and socio-economic threat. Since 2013, when a nearby gold mining company was liquidated, this community has been complaining about dust fallout. To validate the claims made by the community this paper reports on the dust deposition impacts, and respiratory illnesses risk posed by wind-blown generated dust. The study conducts an air quality assessment using dispersion modelling of windblown dust. Surface material from the TSFs was sampled, analysed for silica and heavy metal content using X-ray fluorescence (XRF) and inductively coupled plasma-mass spectrometry (ICP-MS) respectively. This study finds that PM10 dust fallout, high in silica and uranium content, could potentially pose health threats to the surrounding community. The study further shows that dust deposition is the highest in July–October, with TSF6 posing a nuisance while TSF1 represents a potential health threat owing to its particle size distribution for the surrounding gold mine village community. Potential receptors of the air pollution by dust in this study area include neighbouring property owners, business owners of the nearby shopping centre, the school and the clinic. This study further finds that sudden mine closure due to mine liquidation results in unrehabilitated tailings storage facilities which exacerbates dust deposition.
Landslide Susceptibility Mapping Using Machine Learning Algorithms and Remote Sensing Data in a Tropical Environment
Authors: Nhu Viet-Ha , Mohammadi Ayub , Shahabi Himan , Ahmad Baharin Bin , Al-Ansari Nadhir , Shirzadi Ataollah , Clague John J. , Jaafari Abolfazl , Chen Wei , Nguyen Hoang
Published: July 2020

We used AdaBoost (AB), alternating decision tree (ADTree), and their combination as an ensemble model (AB-ADTree) to spatially predict landslides in the Cameron Highlands, Malaysia. The models were trained with a database of 152 landslides compiled using Synthetic Aperture Radar Interferometry, Google Earth images, and field surveys, and 17 conditioning factors (slope, aspect, elevation, distance to road, distance to river, proximity to fault, road density, river density, normalized difference vegetation index, rainfall, land cover, lithology, soil types, curvature, profile curvature, stream power index, and topographic wetness index). We carried out the validation process using the area under the receiver operating characteristic curve (AUC) and several parametric and non-parametric performance metrics, including positive predictive value, negative predictive value, sensitivity, specificity, accuracy, root mean square error, and the Friedman and Wilcoxon sign rank tests. The AB model (AUC = 0.96) performed better than the ensemble AB-ADTree model (AUC = 0.94) and successfully outperformed the ADTree model (AUC = 0.59) in predicting landslide susceptibility. Our findings provide insights into the development of more efficient and accurate landslide predictive models that can be used by decision makers and land-use managers to mitigate landslide hazards.
The Influence of Ideological Variables in the Denial of Violence Against Women: The Role of Sexism and Social Dominance Orientation in the Spanish Context
Authors: Canto Jesús M. , Vallejo-Martín Macarena , Perles Fabiola , San Martín Jesús
Published: July 2020

Violence against women in heterosexual intimate relationships is a major social problem with serious physical and psychological consequences for the victims. There is a line of research that seeks to analyze how ideological variables and contextual variables influence the way in which this type of violence is perceived. This study analyzed the relationship between hostile sexism, benevolent sexism and social dominance in the acceptance of the myths about violence against women in intimate relationships. A total of 215 Spanish university students (125 women and 90 men) participated in the research. The results indicate that hostile sexism and social dominance orientation act as factors that influence the acceptance of such myths in men. Benevolent sexism did not act in this way. The data reconfirm the importance of hostile sexism and social dominance orientation in the perception of violence against women, in this case, that which is committed by their partners (or ex-partners) in the area of intimate relationships.
Socially Responsible Investing as a Competitive Strategy for Trading Companies in Times of Upheaval Amid COVID-19: Evidence from Spain
Authors: Palma-Ruiz Jesús Manuel , Castillo-Apraiz Julen , Gómez-Martínez Raúl
Published: July 2020

Sustainable and responsible investing (SRI) is a strategy that seeks to combine both financial return and social good. The need to create and preserve SRI represents a key argument in investment decision-making, which leads other firms and investors to make strategic decisions beyond financial logic, based on environmental, social, and governance (ESG) factors. Within this framework, this paper aims to further clarify the understanding of potentially profitable strategies for firms during a global crisis such as a pandemic. Both primary and secondary data were gathered, and descriptive analyses were conducted. In Spain, several IBEX-35 companies announced donations amid the COVID-19 crisis. First, companies were classified into two groups based on donations made. For this, we searched for ESG online news. Then, profitability records amongst companies were identified and compared. In the trading session after the announcements, we found 12 of the 35 companies that made donations had a higher performance index of more than 2 and 3 points over the companies that did not make donations. With a weekly perspective, the difference was 91 and 60 basis points, respectively. These results suggest that in times of upheaval, investors base their strategy on ESG factors, contributing to the emerging literature on individual motives of SRI. Second, by conducting a survey and collecting data from 575 Spanish citizens, we conclude that after this crisis, people’s perceptions towards corporate social responsibility (CSR) will change, affecting consumption preferences in those companies that exhibited socially irresponsible or unsupportive behaviour. Hence, the reputation of firms, their social image, and social trust will play an important role in the near future.
A Pilot Study of the Predictive Potential of Chemosensitivity and Gene Expression Assays Using Circulating Tumour Cells from Patients with Recurrent Ovarian Cancer
Authors: Guadagni Stefano , Clementi Marco , Masedu Francesco , Fiorentini Giammaria , Sarti Donatella , Deraco Marcello , Kusamura Shigeki , Papasotiriou Ioannis , Apostolou Panagiotis , Aigner Karl Reinhard , Zavattieri Giuseppe , Farina Antonietta Rossella , Vizzielli Giuseppe , Scambia Giovanni , Mackay Andrew Reay
Published: July 2020

Circulating tumour cells (CTCs) from liquid biopsies are under current investigation in several cancers, including epithelial ovarian cancer (EOC) but face significant drawbacks in terms of non-standardised methodology, low viable cell numbers and accuracy of CTC identification. In this pilot study, we report that chemosensitivity assays using liquid biopsy-derived metastatic EOC CTCs, from 10 patients, nine with stage IIIC and one with stage IV disease, in progression after systemic chemotherapy, submitted for hypoxic isolated abdominal perfusion (HAP), are both feasible and useful in predicting response to therapy. Viable metastatic EOC CTCs (>5 cells/mL for all 10 blood samples), enriched by transient culture and identified by reverse transcription polymerase chain reaction (RT-PCR) and indirect immunofluorescence (IF), were subjected to flow cytometry-based Annexin V-PE assays for chemosensitivity to several chemotherapeutic agents and by RT-PCR for tumour gene expression profiling. Using a cut-off value of >80% cell death, CTC chemosensitivity tests were predictive of patient RECIST 1.1 responses to HAP therapy associated with 100% sensitivity, 50% specificity, 33% positive predictive, 100% negative predictive and 60% accuracy values. We propose that the methodology employed in this study is feasible and has the potential to predict response to therapy, setting the stage for a larger study.
Obesity and Cancer: 27-Hydroxycholesterol, the Missing Link
Authors: Asghari Arvand , Umetani Michihisa
Published: July 2020

Obesity is currently affecting more than 40% of the Americans, and if it progresses with this rate, soon one out of two Americans will be obese. Obesity is an important risk factor for several disorders including cardiovascular disease, the first cause of death in the United States. Cancer follows as the second deadliest disease, and a link between obesity and cancer has been suggested. However, it is very hard to establish an exact connection between obesity and cancers due to the multifactorial nature of obesity. Hypercholesterolemia is a comorbidity of obesity and also linked to several cancers. Recently a cholesterol metabolite 27-hydroxycholesterol (27HC) was found to be an endogenous selective estrogen receptor modulator (SERM), which opened new doors toward several interesting studies on the role of this molecule in biological disorders. It is speculated that 27HC might be the missing link in the obesity and cancer chain. Here, we explored the effects of 27-hydroxycholesterol on obesity and cancers with a focus on the SERM capacity of 27HC.
Distal-Less Homeobox 5 Is a Therapeutic Target for Attenuating Hypertrophy and Apoptosis of Mesenchymal Progenitor Cells
Authors: Twomey-Kozak John , Desai Salomi , Liu Wenguang , Li Neill Y. , Lemme Nicholas , Chen Qian , Owens Brett D. , Jayasuriya Chathuraka T.
Published: July 2020

Chondrocyte hypertrophy is a hallmark of osteoarthritis (OA) pathology. In the present study, we elucidated the mechanism underlying the relationship between the hypertrophy/apoptotic phenotype and OA pathogenesis in bone marrow-derived mesenchymal stem cells (BM-MSCs) via gene targeting of distal-less homeobox 5 (DLX5). Our primary objectives were (1) to determine whether DLX5 is a predictive biomarker of cellular hypertrophy in human osteoarthritic tissues; (2) To determine whether modulating DLX5 activity can regulate cell hypertrophy in mesenchymal stem/progenitor cells from marrow and cartilage. Whole transcriptome sequencing was performed to identify differences in the RNA expression profile between human-cartilage-derived mesenchymal progenitors (C-PCs) and bone-marrow-derived mesenchymal progenitors (BM-MSCs). Ingenuity Pathway Analysis (IPA) software was used to compare molecular pathways known to regulate hypertrophic terminal cell differentiation. RT-qPCR was used to measure DLX5 and hypertrophy marker COL10 in healthy human chondrocytes and OA chondrocytes. DLX5 was knocked down or overexpressed in BM-MSCs and C-PCs and RT-qPCR were used to measure the expression of hypertrophy/terminal differentiation markers following DLX5 modulation. Apoptotic cell activity was characterized by immunostaining for cleaved caspase 3/7. We demonstrate that DLX5 and downstream hypertrophy markers were significantly upregulated in BM-MSCs, relative to C-PCs. DLX5 and COL10 were also significantly upregulated in cells from OA knee joint tissues, relative to normal non-arthritic joint tissues. Knocking down DLX5 in BM-MSCs inhibited cell hypertrophy and apoptotic activity without attenuating their chondrogenic potential. Overexpression of DLX5 in C-PCs stimulated hypertrophy markers and increased apoptotic cell activity. Modulating DLX5 activity regulates cell hypertrophy and apoptosis in BM-MSCs and C-PCs. These findings suggest that DLX5 is a biomarker of OA changes in human knee joint tissues and confirms the DLX5 mechanism contributes to hypertrophy and apoptosis in BM-MSCs.
Cognitive-Behavioural Correlates of Dysbiosis: A Review
Authors: Luca Maria , Chattipakorn Siriporn C. , Sriwichaiin Sirawit , Luca Antonina
Published: July 2020

Evidence suggests an association between an altered gut microbiota (dysbiosis), cognitive performance and behaviour. This paper provides an overview of the current literature regarding the cognitive-behavioural correlates of dysbiosis, with special attention on the clinical and biochemical mechanisms underlying the association between dysbiosis, cognition (mild cognitive impairment and dementia) and behaviour (depression, schizophrenia, addiction). After providing an overview of the evidence, the review discusses the molecular aspects that could account for the cognitive-behavioural correlates of dysbiosis. Shedding light on this topic could provide insights regarding the pathogenesis of these burdening neuropsychiatric disorders and even suggest future therapeutic strategies.
Comparison and Sensibility Analysis of Warning Parameters for Rotating Stall Detection in an Axial Compressor
Authors: Margalida Gabriel , Joseph Pierric , Roussette Olivier , Dazin Antoine
Published: July 2020

The present paper aims at evaluating the surveillance parameters used for early stall warning in axial compressors, and is based on unsteady pressure measurements at the casing of a single stage axial compressor. Two parameters—Correlation and Root Mean Square (RMS)—are first compared and their relative performances discussed. The influence of sensor locations (in both radial and axial directions) is then considered, and the role of the compressor’s geometrical irregularities in the behavior of the indicators is clearly highlighted. The influence of the throttling process is also carefully analyzed. This aspect of the experiment’s process appears to have a non-negligible impact on the stall warning parameters, despite being poorly documented in the literature. This last part of this research work allow us to get a different vision of the alert parameters compared to what is classically done in the literature, as the level of irregularity that is reflected by the magnitude of the parameters appears to be an image of a given flow rate value, and not a clear indicator of the stall inception.