bluuebunny/crossref_metadata_2025 huggingface dataset:
Anthropogenic CO2, air–sea CO2 fluxes, and acidification in the Southern Ocean: results from a time-series analysis at station OISO-KERFIX (51° S–68° E)
Authors: Metzl Nicolas , Lo Monaco Claire , Leseurre Coraline , Ridame Céline , Reverdin Gilles , Chau Thi Tuyet Trang , Chevallier Frédéric , Gehlen Marion
Published: June 2024

Abstract. The temporal variation of the carbonate system, air–sea CO2 fluxes, and pH is analyzed in the southern Indian Ocean, south of the polar front, based on in situ data obtained from 1985 to 2021 at a fixed station (50°40′ S–68°25′ E) and results from a neural network model that reconstructs the fugacity of CO2 (fCO2) and fluxes at monthly scale. Anthropogenic CO2 (Cant) is estimated in the water column and is detected down to the bottom (1600 m) in 1985, resulting in an aragonite saturation horizon at 600 m that migrated up to 400 m in 2021 due to the accumulation of Cant. At the subsurface, the trend of Cant is estimated at +0.53±0.01 µmol kg−1 yr−1 with a detectable increase in the trend in recent years. At the surface during austral winter the oceanic fCO2 increased at a rate close to or slightly lower than in the atmosphere. To the contrary, in summer, we observed contrasting fCO2 and dissolved inorganic carbon (CT) trends depending on the decade and emphasizing the role of biological drivers on air–sea CO2 fluxes and pH inter-annual variability. The regional air–sea CO2 fluxes evolved from an annual source to the atmosphere of 0.8 molC m−2 yr−1 in 1985 to a sink of −0.5 molC m−2 yr−1 in 2020. Over 1985–2020, the annual pH trend in surface waters of -0.0165±0.0040 per decade was mainly controlled by the accumulation of anthropogenic CO2, but the summer pH trends were modulated by natural processes that reduced the acidification rate in the last decade. Using historical data from November 1962, we estimated the long-term trend for fCO2, CT, and pH, confirming that the progressive acidification was driven by the atmospheric CO2 increase. In 59 years this led to a diminution of 11 % for both aragonite and calcite saturation state. As atmospheric CO2 is expected to increase in the future, the pH and carbonate saturation state will decrease at a faster rate than observed in recent years. A projection of future CT concentrations for a high emission scenario (SSP5-8.5) indicates that the surface pH in 2100 would decrease to 7.32 in winter. This is up to −0.86 lower than pre-industrial pH and −0.71 lower than pH observed in 2020. The aragonite undersaturation in surface waters would be reached as soon as 2050 (scenario SSP5-8.5) and 20 years later for a stabilization scenario (SSP2-4.5) with potential impacts on phytoplankton species and higher trophic levels in the rich ecosystems of the Kerguelen Islands area.
Dynamical reconstruction of the upper-ocean state in the central Arctic during the winter period of the MOSAiC expedition
Authors: Kuznetsov Ivan , Rabe Benjamin , Androsov Alexey , Fang Ying-Chih , Hoppmann Mario , Quintanilla-Zurita Alejandra , Harig Sven , Tippenhauer Sandra , Schulz Kirstin , Mohrholz Volker , Fer Ilker , Fofonova Vera , Janout Markus
Published: June 2024

Abstract. This paper presents a methodological tool for dynamic reconstruction of the state of the ocean, based, as an example, on observations from the Multidisciplinary drifting Observatory for the Study of Arctic Climate (MOSAiC) experiment. The data used in this study were collected in the Amundsen Basin between October 2019 and January 2020. Analysing observational data to assess tracer field and upper-ocean dynamics is highly challenging when measurement platforms drift with the ice pack due to continuous drift speed and direction changes. We have equipped the new version of the coastal branch of the global Finite-volumE sea ice–Ocean Model (FESOM-C) with a nudging method. Model nudging was carried out assuming a quasi-steady state. Overall, the model can reproduce the lateral and vertical structure of the temperature, salinity, and density fields, which allows for projecting dynamically consistent features of these fields onto a regular grid. We identify two separate depth ranges of enhanced eddy kinetic energy located around two maxima in buoyancy frequency: the depth of the upper halocline and the depth of the warm (modified) Atlantic Water. Simulations reveal a notable decrease in surface layer salinity and density in the Amundsen Basin towards the north but no significant gradient from east to west. However, we find a mixed-layer deepening from east to west, with a 0.084 m km−1 gradient at 0.6 m km−1 standard deviation, compared to a weak deepening from south to north. The model resolves several stationary eddies in the warm Atlantic Water and provides insights into the associated dynamics. The model output can be used to further analyse the thermohaline structure and related dynamics associated with mesoscale and submesoscale processes in the central Arctic, such as estimates of heat fluxes or mass transport. The developed nudging method can be utilized to incorporate observational data from a diverse set of instruments and for further analysis of data from the MOSAiC expedition.
Magnetic graphene oxide: Synthesis techniques and applications in gas-sensor and biosensors
Authors: Dashtipour
Published: June 2024

In recent years, there has been a notable increase in interest in magnetic graphene oxide (MGO) due to its unique properties and potential applications in gas and biosensors. An extensive summary of the MGO synthesis techniques, such as chemical reduction, hydrothermal synthesis, and solvothermal synthesis, is given in this review article. Along with its many uses in gas and biosensors, sensitivity, selectivity, and stability of MGO are also highlighted. In addition to being a gas sensor that can identify ammonia, hydrogen sulfide, and volatile organic compounds, MGO can be used as a biosensor to identify proteins, glucose, cholesterol, and DNA. The conclusion of article discusses the future directions of the field as well as possible applications for MGO research across a range of industries.
Development of Independent Curriculum Learning Tools to Increase 5th Grade Student Activeness and Science Literacy
Authors: . Heriyanto , Sukmayadi Dodi
Published: June 2024

Development of independent curriculum learning tools in the form of teaching modules. The development of teaching modules aims to develop competencies that cover the cognitive, psychomotor and affective domains. This research aims to develop a teaching module by applying the Project Based Learning (PjBL) learning model to increase the activeness and scientific literacy of class V students. The type of research used is research and development with the research model developed being the Borg and Gall model. The product developed is a teaching module. Data collection is carried out through device validation sheets. Data analysis was carried out using qualitative and quantitative methods. The validity results obtained show that the teaching module with an overall average of 91.43% is in very valid criteria. The teacher's ability and student responses show good grades so that it can be said that the teaching module used meets the practicality criteria. The normality test on the use of teaching modules with the application of Project Based Learning (PjBL) shows an increase in students' scientific literacy abilities in experimental or treatment classes, so that the teaching modules used meet practicality criteria.

Keywords: Independent Curriculum, Project Based Learning, Scientific Literacy
Perbandingan Pengujian Manual dan Terotomasi pada Software Enterprise Resource Planning
Authors: Rahmat Fauzan  , Ferina Putri Soedjono  , Annisa Ayu Permadani  , Muhammad Ainul Yakin
Published: June 2024

Pengujian pada software ERP (Enterprise Resource Planning) merupakan aspek penting dalam pengembangan dan pemeliharaan sistem ERP. Namun, software ERP memiliki sistem yang kompleks sehingga memerlukan pengujian yang efisien dan akurat. Untuk menyelesaikan permasalahan tersebut, kami melakukan pengujian fungsional pada software ERP secara manual dan otomatis. Dari pengujian tersebut, kami membandingkan efisiensi dari pengujian manual dan otomatis pada software, khususnya pada software ERP. Dalam pengujian otomatis kami menggunakan Selenium IDE sebagai alat penguji sedangkan pengujian manual dilakukan dengan melibatkan manusia sebagai penguji. Setelah pengujian dilakukan, didapatkan hasil bahwa pengujian otomatis lebih efisien dalam segi waktu. Sedangkan dalam segi tingkat kesuksesan, pengujian manual dan otomatis memiliki hasil yang sama yakni 93,75%.
Demandingness Objection in Kant’s Ethical Philosophy: Conversational Implicature and Kant’s notion of Willlkur
Authors:   Department of Philosophy and Logic, Master of Arts (M.A.) at the Faculty of Humanities, Tarbiat Modares University, Tehran, Iran., Fallahrafie Ramezanali , Singh Rajdeep ,   Department of Philosophy and Logic, Master of Arts (M.A.) at the Faculty of Humanities, Tarbiat Modares University, Tehran, Iran.
Published: June 2024

In this contribution we will discuss the demandingness objection with regard to Kant?s ethics. While in the literature there has been an emphasis on this issue with regard to imperfect duties, our main goal is to show Kantian ethics has resources to resort to in the case of the demandingness objection with regard to both perfect and imperfect duties. We consider different possible components of a moral theory which can lead to demandingness introduced by Scheffler. While we concur with Kantian critics that the stringent content of Kantian ethics may be a source of demandingness, we show that Kantian ethics has resources to respond to over demandingness objection arisen from other components. For this purpose we discuss Kant?s notion of ?Vorsatz? (intention), accompanied by the device of Flouting, introduced by Grice in his Conversational Implicatures.
The Progression of Trade Policy Reforms within the Context of National Economic Reforms
Authors: Gautam Prof. V. K.
Published: June 2024

The primary goal of this chapter is to outline the key points of the trade policy reforms that have taken place in India since 1991, focusing on the changes that have occurred both before and after the reforms. Specifically, a comprehensive analysis that aims to comprehend the key components of the trade policy reform initiatives. Using the many metrics of India's international trade performance throughout the Reform years, as well as the direction and makeup of India's imports and exports, the movements in India's external sector have been examined in depth.
The Benefits of Laser Therapy and Hooking in the Treatment of Plantar Fasciitis: A Narrative Review
Authors: Pereira Emanuella Araújo , Arruda Francisca Viviane , Rocha Kamilla Jessica Melo da , Vieira Maria Nacélia , Lopes Junior Jose Evaldo Gonçalves , Vanderlei Edfranck de Sousa , Almeida e Neves Eduardo de
Published: June 2024

Plantar fasciitis is an inflammation that affects the plantar aponeurosis, causing pain. Although it is not a lethal injury, if left untreated, it can become a disabling condition. Laser therapy is a physiotherapy treatment that provides an analgesic effect, acting on acute or chronic bone and tendon injuries, increasing collagen synthesis and phagocytic activity, repair, and the release of cytokines that will reduce the inflammatory reaction. Hooking is a tool that has been widely used by physiotherapists due to its low cost, ease of use, non-invasive nature, and its indication for the treatment of numerous traumatic injuries and inflammations of the musculoskeletal system in general, as well as scar tissue adhesions. The aim of this study was to report the benefits of laser therapy and hooking in the treatment of plantar fasciitis. Here, Laser therapy demonstrated significant improvement in 2 of the 3 articles found for this review, potentially providing improvement in pain, healing process, among others. Therefore, more high-quality studies are needed to prove the efficacy of laser treatment in plantar fasciitis. The present study showed positive effects of both techniques. Reports show good results and efficacy in the treatment of plantar fasciitis
КЫРГЫЗСТАНДАГЫ ЖАШТАР АРАСЫНДАГЫ МИГРАЦИЯ МАСЕЛЕЛЕРИ
Authors: Макыев Сагынбек , Табалдиева Назгуль
Published: June 2024

Макалада жаштардын миграциясы көйгөйү заманбап дүйнөдө кеңири таралган көрүнүш катары көтөрүлөт. Миграция жөнөтүүчү жана кабыл алуучу аймактардын калкынын жаш-жыныстык структурасын олуттуу түрдө өзгөртөт. Миграциянын жаштар аспектиси талданат, анткени азыркы дүйнөдө жаштар бардык мигранттардын олуттуу үлүшүн түзөт; жаштардын миграциясынын себептерин жана кесепеттерин талкуулайт.
ЖАШЫЛ ДОЛБООРЛОРДУ КАРЖЫЛОО: ӨЗГӨЧӨЛҮКТӨРҮ, ТОБОКЕЛДИКТЕР ЖАНА КУРАЛДАР
Authors: Карбекова Азиза , Качканбаева А.С. , Сайпидинов И.М.
Published: June 2024

Изилдөөнүн предмети өнөр жай ишканаларынын “жашыл” долбоорлору болуп саналат. Иштин максаты – “жашыл” долбоорлорду каржылоонун өзгөчөлүктөрүн изилдөө, талдоо жана колдонуу. Макаланын актуалдуулугу “жашыл” экономиканы, анын ичинде “жашыл” долбоорлорду өнүктүрүү боюнча мыйзам ченемдерин иш жүзүндө ишке ашыруу маселелерин чечүү зарылчылыгы менен аныкталат. Келечекте жашыл компанияларга оператордук моделине жана когнитивдик карталарга негизделген куралдарды колдонуу сунушталат.
ПОВЫШЕНИЯ ЭНЕРГОЭФФЕКТИВНОСТИ ЗДАНИЙ КАК ОСНОВА ЭКОЛОГИЧЕСКОЙ УСТОЙЧИВОСТИ ГОРОДОВ В КЫРГЫЗСКОЙ РЕСПУБЛИКЕ
Authors: Карбекова Мээримай
Published: June 2024

Данная статья рассматривает важность повышения энергоэффективности зданий в Кыргызской Республике для обеспечения экологической устойчивости городов. Рассмотрены уровень энергозатратности экономики Кыргызской Республики, экологические показатели и необходимости обеспечения энергоэффективности за счет снижения энергопотребления. Авторы анализируют текущее состояние энергопотребления зданий, проблемы и препятствия на пути к улучшению энергоэффективности зданий. Показаны решения проблем повышения энергоэффективности зданий путем выбора энергоэффективных теплоизоляционных материалов, а также предложены практические рекомендации для реализации эффективных мер по снижению энергопотребления зданий в Кыргызской Республике
ИННОВАЦИОННЫЕ СТРАТЕГИИ КАК ФАКТОР СТАБИЛЬНОГО РАЗВИТИЯ ОРГАНИЗАЦИЙ
Authors: Сакибаев Канатбек , Нурали кызы Айкокул , Нуралимова Бегимай
Published: June 2024

В статье обоснована сущность стратегии инновационного развития. Рассмотрена классификация стратегий инновационного развития. Авторами на основе проведенных исследований предложена обобщающая характеристика типов инновационной стратегии. Разработанная типы стратегии инновационного развития позволяет определить совокупный коэффициент конкурентоспособности, обеспечивающий возможность ранжирования организаций, выявления сильных и слабых сторон в процессе их функционирования, связанных с осуществлением инновационной деятельности, с учетом внедрения различного типа инноваций. Показана взаимосвязь инновационных стратегий. Выявлена характеристика направлений инновационной стратегии в структуре стратегического управления предприятием.
EXPLORING ENTREPRENEURIAL UNIVERSITIES: A BIBLIOMETRIC ANALYSIS IN THE BUSINESS AND MANAGEMENT FIELDS
Authors: Ray Samrat , Choudhury Raja Roy
Published: June 2024

The following paper features a comprehensive bibliometric analysis of the available literature concerning entrepreneurial universities in the business and management fields. Through scientific databases of Web of Science, 511 papers were ensured and systematically compiled using Bibliometrix-an RStudio package for performance analytics and Science Mapping. It reveals the history of contributing authors, institutions, themes, and geographic focus of articles, published in the field of entrepreneurial universities. The findings show that the topic in question has been gaining more and more attention in recent decades and more publications have been increasingly produced. It revealed renowned writers including Henry Etzkowitz, Loet Leydesdorff, David Audretsch, and distinguished universities including Stanford University, Massachusetts Institute of Technology, and University of Cambridge. Qualitative content analysis identifies several broad research themes, such as university business relations, technology transfer and commercialization, entrepreneurship teaching, and policy. In addition, they emphasize the global significance of entrepreneurial universities based on the contributions of researchers and institutions from around the world. As demonstrated by the United States and Europe being the most productive and relevant regions, it is also imperative that the Asia-Pacific, Latin America, and Africa also offer impressive entrepreneurial output contributing to innovation and economic growth in various geographical environments. Consequently, the results of this study hold important implications for policymakers, educators, and practice in the areas of higher education and entrepreneurship. Policy makers can employ them to formulate better policies and frameworks that will be helpful for entrepreneurial universities and the development of innovation regimes. They can utilise the findings to enhance the curriculum and the programs which could foster the entrepreneurial disposition and skills among students. The study findings will be useful to practitioners such as university administrators and leaders from other sectors to understand and address the drivers of entrepreneurship and technology transfer. In sum, this research serves to extend the body of knowledge and guide policy/ practice in the area of entrepreneurial universities.
ЕВРАЗИЯЛЫК ЭКОНОМИКАЛЫК ИНТЕГРАЦИЯНЫН ШАРТЫНДА КЫРГЫЗ РЕСПУБЛИКАСЫНДАГЫ АУДИТОРДУК ИШТИ ӨНҮКТҮРҮҮ
Authors: Токторов Кубаныч , Ташкулова Гульэра , Чынтурганова Гулнур , Раимбердиев Мыктыбек
Published: June 2024

Макалада Кыргызстандагы аудитордук ишмердүүлүктүн абалы, Евразиялык биримдикке мүчө-мамлекет катары аудитинин эрежелеринин ага тиешелүү ченемдик жана мыйзам актылардагы өзгөрүүлөр, ЕАЭБ аймагында аудитордук кызмат көрсөтүүлөрдү өнүктүрүү  бирдиктүү рыногун түзүү маселелери каралат.
ЭМГЕК МИГРАНТТАРЫНЫН АКЧА КОТОРУУДАГЫ ЗАМАНБАП КӨЙГӨЙЛӨРҮ
Authors: Макыев Сагынбек , Бегмат кызы Гулбарчын
Published: June 2024

Бул макалада мигранттардын акча которууларынын Кыргыз Республикасынын экономикалык трансформациясына тийгизген таасири каралат.Ушуга байланыштуу мигранттардын акча которууларынын көлөмүнүн динамикасына жана алардын Кыргызстандын экономикалык жана социалдык өнүгүүсү үчүн маанисине, өзгөчө макроэкономикалык туруктуулукту камсыз кылуу көз карашынан алганда талдоо жүргүзүлөт. Акча которууларды республиканын экономикасын өнүктүрүү үчүн натыйжалуу пайдалануу жолдору каралды.
ОСОБЕННОСТИ АНАЛИЗА ЗАТРАТ И ДОХОДОВ В СИСТЕМЕ ЗДРАВООХРАНЕНИЯ
Authors: Фозилов Хаёт
Published: June 2024

В данной статье рассмотрены современное состояние и перспективы развития системы здравоохранения Республики Узбекистан, изучены пути повышения качества и эффективности медицинской помощи, определены особенности организации бухгалтерского учета и порядок проведения анализа доходов и расходов организаций здравоохранения.
КЫРГЫЗ РЕСПУБЛИКАСЫНДАГЫ КИЧИ ЖАНА ОРТО ИШКАНАЛАРДЫН РОЛУ ЖАНА ӨНҮГҮҮСҮ
Authors: Ысакова Малахаткан , Шарип кызы Акибаткан , Ысакова Айсулуу
Published: June 2024

Макалада чакан жана орто бизнестин Кыргыз Республикасынын экономикасындагы ролу жана республиканын экономикасына кошкон салымы каралып, чакан жана орто бизнестин статистикалык талдоосу жүргүзүлгөн. Корреляциялык жана регрессиялык анализдин жардамы менен Кыргыз Республикасынын аймагы боюнча чакан жана орто бизнестин өнүгүүсү изилденген. Аймактар ​​боюнча кичи жана орто бизнес үчүн акыркы беш жылга прогноз түзүлдү. Ишкердикти колдоо жана стимулдаштыруу үчүн өзүнчө финансылык жана кредиттик механизмдер сунушталган.
Pancreas Transplantation for the Treatment of Pancreatic Exocrine Disorders
Authors:   Department of Surgery, State University of New York- Downstate, USA., Gruessner Rainer WG , Laftavi Mark R ,   Department of Surgery, State University of New York- Downstate, USA., Pankewycz Oleh ,   Department of Surgery, State University of New York- Downstate, USA., Gruessner Angelika C ,   Department of Surgery, State University of New York- Downstate, USA.
Published: June 2024

Pancreas transplantation is mostly performed to cure diabetes mellitus. However, patients with chronic pancreatitis, cystic fibrosis, benign pancreatic tumors or patients with other exocrine disorders of the pancreas can also be candidates for a pancreas transplant in combination with a kidney, liver or lung or for a pancreas transplant alone. With improvement in surgical techniques and immunosuppressive therapy, pancreas transplant outcomes have improved significantly over the past decade. Mounting evidence supports pancreas transplantation for the treatment of exocrine disorders as an important therapeutic option to restore both endocrine and exocrine function of the pancreas. Patient and graft survival rates are similar to those for pancreas transplants in diabetic patients. A successful pancreas transplant is also more cost efficient and puts less burden on health care spending. However, the risk of immunosuppression and surgery should be carefully evaluated and discussed with the patient. In this review article, we discuss pancreas transplantation for pancreatic exocrine disorders: indications, other treatment options, and outcomes.
Peritoneal Mesothelioma: A Case Report and Review
Authors:   Department of Medical Oncology/Hematology, University of Louisville, Kentucky, USA., Nikita Jain , Aiman Naveed ,   Department of Medical Oncology/Hematology, University of Louisville, Kentucky, USA., Shreyas Kalantri ,   Department of Medical Oncology/Hematology, University of Louisville, Kentucky, USA., Goetz Kloecker ,   Department of Medical Oncology/Hematology, University of Louisville, Kentucky, USA.
Published: June 2024

Despite its low incidence, peritoneal mesothelioma manifests with nonspecific symptoms, often leading to delayed diagnosis. Diagnosis relies on imaging techniques, histopathological evaluation, and immunohistochemistry, with emerging molecular markers refining diagnostic accuracy. The cornerstone of treatment is cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy, tailored to individual tumor characteristics and patient factors. Future directions involve targeted therapies and immunomodulatory agents, emphasizing multidisciplinary collaboration and translational research. This review aims to enhance understanding and optimize management, ultimately improving outcomes for affected individuals.
Intraoperative Hyperlactatemia during Facial Gender Affirmation Surgery
Authors:   The Robert Larner M.D. College of Medicine at the University of Vermont, Burlington, VT, USA., Sarathy Ashwini , Bhethanabotla Rohith M ,   Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA., Mohan Suresh ,   Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA., Park Andrea ,   Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA., Knott P Daniel ,   Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA., Seth Rahul ,   Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, CA, USA.
Published: June 2024

Hyperlactatemia is defined as elevations in blood lactate >2 mmol above baseline without concurrent metabolic acidosis [1]. Prolonged hyperlactatemia can be an independent risk factor for worse outcomes as lactate is a byproduct of anaerobic metabolism and linked with tissue ischemia and/or organ dysfunction. In head and neck surgical patients, normalization of hyperlactatemia is crucial to decrease mortality and postoperative complications [2]. However, even in critically-ill surgical patients, hyperlactatemia is not necessarily indicative of circulatory failure [3]. Our center has anecdotally noted hyperlactatemia in patients undergoing Facial Gender-Affirmation Surgery (FGAS), but it remains unclear whether it corresponds directly to adverse clinical outcomes. The present study sought to examine implications of intraoperative hyperlactatemia during FGAS.
Cosmetic Gynecology
Authors:   Department of Obstetrics & Gynecology, AIIMS, Bilaspur, H.P, India., Kaundal Asmita , Kothiwala Mayuri ,   Founder Director of Institute of Interventional Dermatology and Aesthetic Gynecology, Rajasthan, India.
Published: June 2024

Cosmetic Gynecology (CG) is a rapidly emerging subspecialty. With the large media coverage, it had gained popularity in last few years. This review aims to provide an overview of the advancements, techniques, and considerations in aesthetic gynecology. We discuss common procedures such as labiaplasty, vaginal rejuvenation, and clitoral hood reduction, highlighting their indications, surgical techniques, outcomes, and patient satisfaction. Additionally, we explore emerging trends such as non-surgical treatments using laser therapy and Platelet-Rich Plasma (PRP) for tissue rejuvenation. Ethical considerations, patient education, and the importance of a multidisciplinary approach are also discussed. GC addresses both functional as well as aesthetic aspect of female external genitalia and is being considered as an excellent opportunity to address psychosexual issues if present. Overall, aesthetic gynecology offers valuable options to improve women’s confidence, comfort, and quality of life.
Abnormal Uterine Bleeding following by COVID-19 Vaccine
Authors:   Gynecologist , Assistant Professor of Alborz University of Medical Sciences Department of Obstetrics and Gynecologists, Alborz University of Medical Sciences, Karaj, Iran., Farahani Masoumeh
Published: June 2024

Background: After the COVID-19 vaccination, concerns about side effects were rised globally. One of the reported side effects was changes in menstrual periods. In this study, we aimed to evaluate changes in the menstrual cycle, including frequency, length, abnormal bleeding, and pain after the COVID-19 vaccine.
Emotions and Caregiver’s Needs in Patients with Alzheimer’s Disease: The Caregiver Burden
Authors:   Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy., L Tomasello , M Ranno ,   Faculty of Medicine and Dentistry, Sapienza University of Rome, Italy., M Raffaele ,   Department of Clinical and Experimental Medicine, University of Messina, Italy., A Laganà ,   Department of Biomedical and Dental Sciences, Morphological and Functional Images, Italy., C Pitrone ,   Department of Biomedical and Dental Sciences, Morphological and Functional Images, Italy., C Zaccone ,   Department of Clinical and Experimental Medicine, University of Messina, Italy., A Alibrandi ,   Departiment of Economics, University of Messina, Italy.
Published: June 2024

The burden on the caregiver patients with Alzheimer disease need assistance and supervision in their daily activities. In literature, the term “burden” has been used to indicate the overload of work experienced by the caregiver. In our country, the patient’s domiciliary “take-care system” is based firstly on the family support together with the supply of health care providers and home care professionals provided by the National Health System. Caregivers of Alzheimer’s Disease (AD) patients are usually subjected to enormous physical and mental stress, as well as emotional, which may have repercussions on personal, familiar and social contest and, consequently, on life’s quality [1]. The aim of our study was to investigate caregiver’s burden “predicting factors” and evaluates to improve the quality of their caregivers.
Trends in Incidences, Prevalence Cases, and the Disability-Adjusted Life-Years of Bipolar Disorder in China, 1990-2019
Authors:   Department of Prevention and Health, Central Laboratory, Guangzhou Twelfth People’s Hospital, China., Zhong Qiong-Qiong , Zuo Hui ,   Department of Prevention and Health, Central Laboratory, Guangzhou Twelfth People’s Hospital, China., Li Jun-Xiao ,   Department of Prevention and Health, Central Laboratory, Guangzhou Twelfth People’s Hospital, China., F Feng ,   Department of Prevention and Health, Central Laboratory, Guangzhou Twelfth People’s Hospital, China.
Published: June 2024

Objectives: Studies on Chinese bipolar disorders are incomplete and lagged to date. Methods: We used the join point regression program to assess the incidence, prevalence, and disease burdens of Chinese bipolar disorders, based on the Global Burden of Disease exchange database. Results: We observed the increasing trends in the incidence and prevalence of Chinese bipolar disorder in 1990- 2019, with increases of 22.26% in incidence number, 40.73% in prevalence number, and 17.12% in prevalence rate; wherein females had a higher prevalence rate in 1990-2019 and a higher incidence rate in 1990-2013 but a reversed trend thereafter; the Disability-Adjusted Life Years (DALY) increased by 78% for number and 15.81% for rate, respectively; those aged 30-34 shared the highest DALY number in 2019 (73,194; 95% UI (Uncertainty Interval): 43,128-113,623); the DALY-related Annual Percentage Change (APC) in 1990-2019 was 1.21% (P=0.000). Conclusion: Bipolar disorder is being developed into an immense societal burden in China. An essential intervention strategy should be formulated earlier to better identify and treat bipolar disorders so that we can reduce negative outcomes and DALY in China.
Identifying DLAT as a novel therapy target based on integration analysis of the cuproptosis regulatory genes for hepatocellular carcinoma
Authors:   School of Life Sciences, Zhengzhou University, Zhengzhou 45001, China., Guan Xiaowen , Liu Zhentao ,   School of Life Sciences, Zhengzhou University, Zhengzhou 45001, China., Wang Jianwei ,   School of Computer and Artificial Intelligence, Zhengzhou University, Zhengzhou 45001, China., Yang Wei ,   School of Life Sciences, Zhengzhou University, Zhengzhou 45001, China.
Published: June 2024

Cuproptosis is a newly found Regulated Cell Death (RCD) form, dependent on copper and mitochondrial respiration. However, limited available researches of the roles of cuproptosis regulators in prognosis and development of Hepatocellular Carcinoma (HCC) prompted us to conduct this investigation. In our study, we systematically analyzed the expression levels and prognostic profiles of 27 cuproptosis regulatory genes in HCC samples downloaded from The Cancer Genome Atlas (TCGA) cohort and developed a prognostic risk model based on 7 genes (NDUFA1, NDUFB2,DLD, DLAT, MTF1, ATP7B, GCSH) by performing step AIC method and multivariate cox regression analysis. The independent prognostic values of the risk score were also validated in the external International Cancer Genome Consortium (ICGC) cohort. Moreover, the Overall Survival (OS) of HCC patients in the low-risk group was significantly longer than that in the high-risk group. Notably, the expression level of DLAT was found to be higher in the HCC tissues compared with normal tissues and high DLAT expression correlated with a poor prognosis. The function of DLAT was further validated in vitro using siRNA tool, DLAT depletion inhibited the proliferation and migration of HCC cells which indicated that DLAT was a potential and promising therapeutic target for HCC.
Mitochondrial proteins and colorectal cancer risk: A mendelian randomization study
Authors:   Department of Gastrointestinal Oncology, First Affiliated Hospital of China Medical University, Shenyang, China., Wu Donglei , Tong Dafeng ,   Department of General Surgery, Changhai Hospital, Navy Military Medical University, Shanghai, China., Gao Ming ,   Department of Gastroenterology, Dalian Municipal Central Hospital, Dalian, China., Zhang Xin ,   Department of General Surgery, Changhai Hospital, Navy Military Medical University, Shanghai, China., Hu Xuguang ,   Department of General Surgery, Changhai Hospital, Navy Military Medical University, Shanghai, China.
Published: June 2024

Background: Mitochondrial dysfunction has been implicated in Colorectal Cancer (CRC) development. However, evidence for a causal relationship between mitochondrial proteins and CRC risk is lacking. This study aimed to explore the causal associations between mitochondrial proteins and CRC risk using a two-sample Mendelian Randomization (MR) approach.
THE PROFESSIONAL TRANSLATION'S VALUABILITY AND THE FEATURES OF AUTOMATED TRANSLATION UNDER MODERN CIRCUMSTANCES
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Turaeva Shakhnoza
Published: June 2024

The article is devoted to the perspective of the "translator" profession in the modern world, to the analysis of the translation market in Uzbekistan, as well as to scientific works on researching the use of computer programs in this field. One of the main a spect soft hearticleistorevealthenatureandactivityof thetopicof translation.
MOTIVES FOR INCREASING PEDAGOGICAL ACHIEVEMENT COMPETENCIES OF TEACHERS AND EDUCATORS OF FOREIGN LANGUAGES
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Radjabova Jayron
Published: June 2024

The article emphasizes theimportance of pedagogical training of philology students and the formation of pedagogical competence at the university. In this regard, the motives for increasing the pedagogical competence of teachers and teachers of a foreign language are considered. Having a high level of linguistic competence does not mean that the same level of pedagogical competence is inherent in a teacher or university lecturer. The authors analyzed the differences in the motivation to improve the pedagogical competence of teachersand foreign language teachers. The article also pays attention to the motives for choosing a profession and the orientation of teachers and professors.
USINGEDUCATIONAL PODCASTSTO DEVELOP LISTENING SKILLS
Authors:   Tashkent University of Information Technologies, Saidvalieva Dilafruz
Published: June 2024

Today, podcasting has expanded beyond amateur radio. On specialized portals you can find officialpodcasts from terrestrial radio stations, television channels and large companies, such as news, stock reviews or information about new services. Podcasts have become popular and convenient means of transmitting information especially in teaching listening in English classes
THE ROLE OF CHILDREN'S LITERATURE IN TEACHING FOREIGN LANGUAGES (AS AN EXAMPLE OF THE WORKS OF THE AMERICAN WRITER DR. SEUSS)
Authors:   Tashkent State Law University, Burieva Gulhayo
Published: June 2024

This article discusses the formation of children's literature as a science and the writers who contributed to it. A proposal to study the works of the American writer Dr. Seuss is included.
KATHARINE MENS FIELD'S IMAGE CREATION SKILLS
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Ataullayeva Sitorabonu
Published: June 2024

This article discusses the portrayal of female characters in the stories of renowned English writer Catherine Mansfield. The article highlights Mansfield's impressive skills in creating vivid characters, utilizing motifs, and employing language. Additionally, the article explores how the feminist movement influenced literature during that time, the representation of women in literature, the challenges they faced in real life, and the call to action to prevent and combat such issues.
VERB STRUCTURE IN ARABIC PROVERBS
Authors:   Tashkent State University of Oriental Studies, Diniqulov Abror
Published: June 2024

Proverbs are sentences used by people to convey wisdom, truth or morals that have been handed down for generations.Verbs play an important role in Arabic proverbs. for this reason, it is an urgent issue to study them separately, especially in Uzbek Arabic studies with modern grammatical terms. Although verbs in the Arabic language can be considered as an object of research many times, the fact that they have not been studied in a perfect form on the scale of Arabic proverbs increases the importance of this article.
THE EFFECT OF MMORPG ONLINE GAMES ON ENHANCING ENGLISH VOCABULARY ACQUISITION FOR EFL PLAYERS: CASE OF PALESTINIAN UNIVERSITY STUDENTS
Authors:   Hisham Bin Abdel Malek Secondary school, Saqfalhett Rawan
Published: June 2024

The study aims to investigate how MMORPG games can improve English vocabulary acquisition among Palestinian university students, focusing on the impact of game design and the use of external resources in the learning process.
PECULARITIES OF TRANSLATION OF PHRASEOLOGICAL UNITS FROM ENGLISH INTO UZBEK
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Turaeva Shakhnoza
Published: June 2024

This article discusses themain ways and means of translating phraseological combinations into English and Uzbek languages. Phraseologies cannot be considered only as a separate part of linguistic science, which can or may not be used, because they constitute an important part of the general vocabulary of the languages. Currently, it is very important to monitor the replenishment of the phraseological fund of the Uzbek and English languages, since idioms appear very quickly, which is associated with the development of branches of science, the introduction of new technologies, political games and military conflicts, the influence of which is also significant for both peoples. It should be noted that phraseological units are common. Phraseological units in the source text and the ability to find the appropriate equivalent in the translation process are the most tangible steps for a translator. However, the translator must use phrasebooks for adequate oral and written translation of phraseological units and, in addition, context plays animportant role in the translation process.
A NEW APPROACH TO TEACHING THE ENGLISH PERFECT TENSE
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Khasanova Maftuna
Published: June 2024

The article describes an attempt to work out a program for teaching such a significant English tense-aspect form as the perfect, the stages of its implementation being outlined and types of educational activities being discussed. The main point of the new approach proposed is not to abandon traditional teaching methods, but to supplement them with an important component: the results of a comparative-contrastiveanalysis ofperfect forms in the English and Russian languages. Before turning to the conventional explanations revealing the formation of the perfect and the semantics of its particular uses, we suggest that students should be imparted a more fundamental concept of perfectivity, which is to be considered diachronically. By using the example of the Russian language, they are to be showed how this category can be expressed by grammatical means. This can be achieved by referring to the results of comparative-contrastiveanalysis. When students come to understand what the diachronically primary meaning of the perfect as a possessive construction is, we can expect that the mechanisms of positive linguistic transposition will work. Employing the ordinary practical contrastive method after that will allow of avoiding linguistic interference in numerous particular cases of its use.
REVOLUTIONIZING ENGLISH LANGUAGE LEARNING: EXPLORING CUTTING-EDGE METHODS IN EDUCATION TECHNOLOGY
Authors:   Alisher Navo'i named after Tashkent state university of uzbek language and literature, Yusupova Nargiza
Published: June 2024

This article describes In the ever-evolving landscape of modern education. In today's rapidly evolving educational landscape, the integration of technology has transformed the way English language learning is approached. This article delves into the forefront of innovation, examining how modern methodologies and technological advancements are revolutionizing the process of learning English.
Educação somática e práticas de mente-corpo orientais
Authors: Amaral Pascoal
Published: June 2024

Desde a antiguidade, questões sobre o corpo e a mente despontam no pensamento da humanidade e conduzem o ser humano para reflexões profundas sobre a existência individual e coletiva. Do Oriente ao Ocidente, as indagações sobre o significado e o valor da relação mente-corpo contribuíram para o desenvolvimento de um número diversificado de filosofias psicofísicas e para a criação de técnicas e de métodos que visam o treino das duas entidades: as práticas mente-corpo (PMC). Através do treino dos aspetos motores, sensoriais, cognitivos e afetivos, as PMC têm como objetivo desenvolver a consciência e promover a homeostase corporal. No mundo ocidental, atualmente é necessário destacar as práticas somáticas como parte das PMC, enquanto que no Oriente é impreterível evidenciar o Taichi, o Qigong e o Yoga devido à sua relevância histórica, metodológica e científica. Na contemporaneidade, e perante os problemas generalizados de âmbito social e de saúde, o estudo do fenómeno mente-corpo extrapolou o domínio académico, e as PMC transformaram-se num recurso importante para a promoção da saúde e bem-estar da população em geral. Através da integração das PMC no dia-a-dia das populações, os indivíduos têm procurado adotar estilos de vida saudáveis e pesquisado, dentro de si mesmos, um propósito para a vida. Partindo desta perspetiva, este estudo tem como objetivos apresentar um enquadramento histórico e metodológico das práticas somáticas e das PMC orientais, identificar os pontos de convergência e de desacordo, descrever os potenciais ganhos, e refletir sobre os aspetos que justificam o investimento na área e a sua integração no ensino.
Memlûk Türk Devletinde Mineli Yaldızlı Cam Süslemeler
Authors: Dönmez Emine
Published: June 2024

13-16. yüzyıllar arasında Mısır ve Suriye topraklarında hüküm süren Memlûk Türk Devleti, cam sanatı bakımından adının her devirde hatırlanmasını sağlayacak eserlerin menbaı olmuştur. Bölgede tarih boyunca var olan ve büyük öneme sahip ticaret ve üretim atölyelerini desteklemiş ve gelişimine katkı sağlamıştır. Alt yapı ve malzeme bakımından çok zengin kaynaklara sahip olan bölgede verimlilik ve maddi elverişlilik sebebiyle çok iyi kalitede camlar üretilmiştir. Sağlamlık ve netliğiyle bilinen bu camlar Memlûkler devrinde bir de bezemeleriyle ün kazanmış, uzun süre rağbet gören ve taklit edilen cam ürünler olma özelliğini korumuştur. Bu çalışmada bölgede cam üretiminin gelişimi ve Memlûklerin bu üretime katkıları aktarılmıştır. Bu çalışmada bölgede üretilen cam emtianın bezenmesi ve bezeme teknikleri hakkında bulgular ışığında genel bir çerçeve çizilmeye çalışılmıştır. Günümüze sağlam olarak ulaşmış, hâlihazırda Viyana Dom Müzesinde sergilenen ve tezyinatıyla öne çıkan bir Memlûk cam şişesinin teknik ve süsleme analizi yapılmıştır. Örnek incelemesi yapılan cam şişe üzerinden Memlûklerde cam sanatı ve süsleme tekniklerinin değerlendirilmesi yapılmıştır.
GIGANTIC INFLUENCES HORMONE IMBALANCES, PITUITARY ADENOMA, GENETIC MUTATIONS AND SYMPTOMS, DIAGNOSIS, DIFFERENTIAL DIAGNOSIS AS WELL AS TREATMENT OF GIGANTISM
Authors: Rao V. Vikunta , Muralinath E.  , Manjari P.  , Pragna K Sravani , KALYAN C.  , Prasad M. Guru , Navven A. Venkat , Sravani. K.  , Sharlet E. Sony
Published: June 2024

Gigantism is a rare endocrine disorder manifested by excessive growth in children and adolescents due to an iver production of growth hormone. Genetic mutations also lead to gigantism. Symptoms include facial changes. Large habds as well feet, muscle weakness, cardio vascular issues, joint problems. Diagnosis involves measuring the level of GH and IGF-1. Treatment concludes surgical reboval of the tumor, medications, long-term follow-Up as well as hormone replacement treatment (HRT).
PRODUCTION OF BIODIESEL FROM A POTENTIAL BIOFUEL CROP MANIHOT ESCULENTA (CASSAVA) A NON EDIBLE OIL SEED AND ITS CHARACTERIZATION METHODS
Authors: Vadiraj K T  , Benny Angel , Achar Raghu Ram
Published: June 2024

Diesel plays an essential role in the industrialized economy of every country. High demand of energy and the fossil fuel spread in industrialized countries will lead to the rapid exhaustion of the resources of fossil fuel and the deterioration of the environment. Because the world's petroleum exploration is so erratically distributed and many regions must rely on others for their fuel needs. The unfamiliar crisis connected with petroleum fuels has forced the modern world to look for feasible alternative fuels. Among the possible alternatives, biodiesel has been recognized as a feasible front runner for many reasons. Biodiesel is composed of long chain fatty acid methyl ester (FAME) obtained by responding triglyceride with lower alcohols like ethanol and methanol in the presence of strong bases. KOH is utilized as a catalyst in the generation of biodiesel. Methanol is used for biodiesel production via trans esterification process. Biodiesel is extracted from the Manihoit esculenta seed oil via trans esterification process. Fuel analysis and GCMS test were conducted for the biodiesel. Gross calorific value, specific gravity and viscosity are the parameters were checked for fuel analysis of biodiesel. The composition of generated biodiesel was discovered via GCMS technique. The chemical and physical analysis of cassava seed oil were observed.
Uso de metodologias laboratoriais para confirmação de surto de doença diarreica aguda causada por múltiplos patógenos
Authors: Marciano Maria Aparecida Moraes , Silva Rafaela Aparecida , Barbosa Maria Luísa , Pinto Pedro Luiz da Silva , Gava Ricardo , Pereira-Chioccola Vera Lucia
Published: June 2024

O objetivo do presente estudo foi investigar um surto causado por protozoários, ocorrido em um município da região sul do Brasil. As investigações foram realizadas analisando 47 amostras de fezes frescas e 26 amostras de água por métodos parasitológicos, moleculares e de imunofluorscência direta. Após as filtrações das amostras de água e purificação das amostras de fezes, os concentrados foram avaliados microscopicamente a procura de parasitas. A seguir, foram analisadas, pela reação em cadeia da polimerase (PCR), a detecção de DNA de Giardia spp., Cryptosporidium parvum, C. hominis e Cyclospora cayetanensis. Das 26 amostras de água, 30,8% (8/26) apresentaram protozoários de veiculação hídrica, sendo que, C. cayetanensis foi o mais prevalente (15,5%). Das 47 amostras de fezes, 23,4% (11/47) estavam infectadas por          C. cayetanensis e Giardia spp. Os resultados mostraram que as águas de retrolavagem dos filtros da Estação de Tratamento de Água estavam contaminadas com C. cayetanensis, C. hominis e Giardia spp. sugerindo a contaminação dos mananciais com dejetos humanos trazidos pelo esgoto. Estes resultados mostram a importância da investigação de protozoários em água e fezes por metodologias laboratoriais, principalmente em surtos que causam doença diarreica aguda.
Factors interfering with the production of Histoplasma capsulatum antigens
Authors: Santos de Freitas-Xavier Roseli , Alves Feitosa Maciel Isabel , Teixeira de Freitas Vera Lúcia , Vicentini Adriana Pardini
Published: June 2024

Histoplasma capsulatum causes systemic mycosis that depends on host susceptibility, fungal virulence, and factors associated with the infectious process. We evaluated the possible interference of the phenotype of 12 samples of H. capsulatum isolated from HIV-positive and negative patients in obtaining antigens, aiming at the serological diagnosis through the gender-specific recognition of the H and M fractions. The antigens were evaluated by double immunodiffusion against H. capsulatum anti-antigen polyclonal antibody and serum samples from patients with histoplasmosis. The phenotypic evaluation revealed differences in the identification of the fungal agent and in the expression of H and M antigens, considered serological markers of the disease, associated with pigmentation and the production of conidia. It was found that antigenic preparations obtained from H. capsulatum isolated from HIV-positive patients may have satisfactory antigenic capacity. The patient’s immune status does not seem to interfere with the expression of antigenic proteins secreted by H. capsulatum. However, we suggest that prolonged use of antiretrovirals drugs or steroids can cause important phenotypic alterations. We showed that some fungal samples from patients with a long history of immunosuppressive drugs produced atypical cellular elements and low reactivity against the H and M fractions.