bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Health Information Literacy of Rural Community Residents Based on Intuitionistic Fuzzy Set Multicriteria
Authors: Zhao Xiaoyan , Ding Sanqing , Zuo Lugen
Published: July 2022

According to the constructed rural community residents’ health information literacy evaluation system, this paper proposes a rural community residents’ health information literacy evaluation method based on intuitionistic fuzzy sets. Based on the intuitionistic fuzzy set, the multistage interactive group evaluation method whose data form is a point set has been expanded, and the intuitionistic fuzzy set that expresses objective things more delicately and truly is used to reflect the evaluator’s preference, which can well simulate the human decision-making psychology and improve the applicability of the interactive group evaluation method. How to accurately measure the value information of relevant intuitionistic fuzzy numbers in uncertain environment has become a difficult problem. Therefore, it is very important to excavate important information in intuitionistic fuzzy numbers, deal with intuitionistic fuzzy numbers, and study the theory and method of multicriteria decision-making under fuzzy information. In this paper, we conducted a research on the health information literacy evaluation model of rural community residents based on intuitionistic fuzzy sets and multicriteria, and found that the formation rate of health behaviors of manual workers is relatively low, and the formation rate of healthy behaviors of female, elderly, and highly educated people is relatively high. A high level of education is conducive to improving the level of residents’ health knowledge.
Causality Tests and Their Applications to China’s Stock and Housing Markets
Authors: He Yugang
Published: July 2022

The link between the stock market and the housing market is well known to be sensitive. At present, the possibility of a connection between them remains intriguing. Therefore, China works as a case study for the research inquiry into the causal relationship between the stock market and the housing market. Using the monthly data from January 2000 to January 2021 and employing the cross‐correlation function approach to perform empirical analysis, the results indicate that the bidirectional causal relationship between the stock market and the housing market has been recognized as one of the most interesting findings, which constitutes a significant departure from previous research. Moreover, the other interesting result is that, from the housing market to the stock market, a causality‐in‐mean and a causality‐in‐variance are discovered. Only a tiny number of previous studies have addressed this achievement in the context of China. Meanwhile, this article’s findings have both theoretical and practical implications for China’s proposition.
[Retracted] Digital Construction of Vocal Music Teaching Resource Base Using Data Mining Technology
Authors: Xu Ning
Published: July 2022

Vocal music teaching resource databases can support teachers’ instruction and students’ learning while also enhancing the school’s ability to run a school because they are the main components of digital construction for vocal music teaching. Currently, system application is the main area of research for DM (data mining), which was previously focused on method discovery. A vocal music teaching resource base based on DM technology is created by using the theme as the central organising principle, processing, and organising the resources. Incorporate lesson planning, teaching, self‐study, and output resource construction into a digital network resource application environment by using thematic resource development. Students’ achievement data, personal basic information, and evaluation data are used for DM based on the enhanced Apriori algorithm in order to uncover hidden rules and find correlations between various factors. This information is then used to support decision‐making. When the system load is 1, the results demonstrate that the Apriori algorithm’s CPU waste rate and task success rate is 0.144 and 0.896, respectively. The study’s conclusion demonstrates that integrating DM technology into the field of education is theoretically and practically possible and that there is significant room for future study and application in this area.
Spectrum Sensing of Noncooperative Beam Signals
Authors: Song Xieda , Li Jinghua , Liu Jiteng , Li Yan , Ding Guoru
Published: July 2022

In this paper, we investigate the issue of spectrum sensing of noncooperative beam signals that are emitted by a multiantenna transmitter. When the sampling period of the sensing node includes the whole process of beam scanning, that is, spectrum sensing is performed in an ideal situation, we use the traditional energy detection algorithm for spectrum sensing and get good results; for multiantenna beam scanning spectrum sensing in nonideal situation, the performance of traditional energy detection algorithm is seriously degraded. To deal with this problem, a sensing period selection (SPS) algorithm is proposed. The simulation results show that the proposed algorithm can effectively improve the performance of spectrum sensing in the multiantenna array beam scanning scenario.
An Improved Neural Network Model for Early Detection of Joint Injuries in Tai Chi Sports
Authors: Shao Zhe , Zhong Yuanyuan , Yu Zhida , Chu Xingping
Published: July 2022

Medical experts and academics are progressively becoming aware of knee injuries faced by tai chi practitioners in China. This occurs when the knee is bent with weight on the foot turned during Tai Chi. We propose an enhanced convolutional neural network (CNN) technique for early warning of joint injury risk during Tai Chi exercise in this research. This improved neural network approach can detect the risk of knee joint injury in practitioners early on to aid in early precaution and treatment. A multiscale feature extraction module is developed by performing several scales of convolutional layer extraction on the input data features and then combining the results to maximize the amount of feature information included in the extracted joint data. The results revealed that in experiments on a Taiwanese Tai Chi community dataset, the proposed method had an average diagnostic accuracy greater than 90 percent, significantly higher than the average diagnostic accuracy of the comparison methods on the dataset.
A Continuous Deep Learning System Study of Tennis Player Health Information and Professional Input
Authors: Gong Lina
Published: July 2022

The health status of elite tennis players and the results of tennis matches are positively proportional under normal circumstances. The physical and psychological functions of tennis players directly affect the athletic ability of tennis players. With the improvement of people’s living standards, people’s attention to tennis has also increased. Tennis has received increasing attention in China, and the training of tennis players has become increasingly necessary. However, China is still using the traditional means of obtaining athletes’ health information to evaluate athletes’ health information. This has led to imperfect research into tennis players’ health information and professional input systems. This makes the understanding of the health information of athletes incomplete and profound, and it affects the athletic ability of athletes. In this paper, deep learning and a two-factor model are added to tennis players’ health information and professional input, and the feasibility of a deep learning system to comprehensively improve health information input is explored. The experimental results show that the application of the convolutional neural network method in the system improves the response speed to the physical fitness state of tennis players by 5%. This adds technical support for timely understanding of tennis players’ physical health information and prevents players from making mistakes on the court due to physical reasons.
Effect of Solitaire FR Stent Thrombectomy Combined with the Suction Thrombus on the Clinical Effect and Prognosis of Acute Middle Cerebral Artery Occlusion
Authors: Wang Tao , Dong Shuyang , Zhang Mei , Yu Chuangqing , Xue Min , Chen Anran
Published: July 2022

To determine the curative effect and prognosis of Solitaire FR stent thrombectomy integrated with the suction thrombus on the treatment of acute middle cerebral artery occlusion (AMCAO). Based on the treatment, patients suffering from AMCAO were separated into the Solitaire FR group (Solitaire FR stent + suction thrombus) and suction group (suction thrombus). Modified thrombolysis in cerebral infarction grading, National Institutes of Health Stroke Scale (NIHSS) score, modified Rankin Scale score, and safety performance were compared between the two groups. The operation time in the suction group was obviously shorter than the Solitaire FR group (

P
<
0.05

). Significant differences were observed in the NIHSS scores 1 week and 4 weeks after the operation between the Solitaire FR group and the suction group (

P
<
0.05

). The NIHSS scores 1 week and 4 weeks after operation were significantly lower than those before operation (

P
<
0.05

). NIHSS scores 1 week after operation did not show obvious difference (

P
>
0.05

). The Solitaire FR group showed obvious lower NIHSS scores than the suction group 4 weeks after surgery (

P
<
0.05

). Statistically obvious difference in cerebral infarction grading of modified thrombolysis between the Solitaire FR group and the suction group were observed (

P
<
0.05

). The recanalization rate of the Solitaire FR group was obviously higher than the suction group (

P
<
0.05

). The difference in the monthly modified Rankin Scale score was obvious (

P
<
0.05

). The good prognosis rate of the Solitaire FR group was obviously higher than the suction group (

P
<
0.05

). No obvious differences in the incidence of internal bleeding, reocclusion, and 3-month postoperative mortality were observed (

P
>
0.05

). These results showed that the treatment of the Solitaire FR stent + suction thrombus in AMCAO patients has a good thrombus recanalization rate and is helpful in improving the prognosis and safety performance.
Curcumol Inhibits the Development of Prostate Cancer by miR-125a/STAT3 Axis
Authors: Sheng Wen , Ding Jin , Liu Lumei , Wang Neng , Lu Baowei , You Xujun , He Qinghu , Zhou Qing
Published: July 2022

Aim. This study aimed to learn the antineoplastic activity of curcumol (Cur) on prostate cancer (PCa) and elucidate its potential molecular mechanism. Methods. The proliferation, invasion, and migration of PCa cells (PC3 and 22RV1) were detected by the cell counting kit 8 (CCK8), transwell, and wound healing assay, respectively. The expression of genes and proteins was analyzed by quantitative real-time polymerase chain reaction (qRT-PCR) and western blotting (WB), respectively. The protein expression in tissues and cells was tested through immunohistochemistry (IHC) and immunocytochemistry (ICC). Enzyme-linked immunosorbent assay (ELISA) was utilized to quantify the level of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF). The interaction between microRNA125a (miR-125a) and the signal transducer and activator of transcription 3 (STAT3) was confirmed via dual-luciferase reporter assay. Results. Cur effectively restrained the proliferation, invasion, and migration of PC3 and 22RV1 cells. After Cur intervention, miR-125a, miR-375, miR-149, miR-183, and miR-106b were all upregulated in PC3 cells, among which miR-125a was the most significantly upregulated. Dual-luciferase reporter assay combined with qRT-PCR and WB experiments confirmed that miR-125a targeted STAT3. Both in vitro and in vivo, Cur enhanced miR-125a expression and suppressed the activation of the STAT3 pathway in PCa. Also, Cur effectively inhibited the growth of PCa. Conclusion. Cur inhibited the development of PCa by miR-125a/STAT3 axis. This may provide a potential agent for treating PCa.
Connecting QuantCrit to Gifted Education Research: An Introduction
Authors: Priddie Christen , Renbarger Rachel
Published: July 2022

This methodological brief introduces researchers to QuantCrit, a set of tenets complementary to critical race theory, to specifically reexamine how race and racism are analyzed through quantitative methodologies. We outline the tenets of QuantCrit, review recent quantitative research in gifted education for examples aligned with QuantCrit tenets, and provide recommendations for researchers.
Effect of Paralytic Agents on Post-Intubation Sedation in the Emergency Department
Authors: Pankey Jessica A. , Christofferson Scott , Barrick Ginger , Knettel Brandon A. , Knettel Christine
Published: July 2022

Purpose: This study aimed to evaluate the frequency at which postintubation sedation is administered following use of long-acting paralytic agents compared to short-acting paralytic agents during rapid sequence intubation performed in the emergency department. Methods: This retrospective, single-center study of intubated patients in the emergency department analyzed the difference in time to administration of additional sedation following use of a short-acting paralytic (succinylcholine) compared to use of a long-acting paralytic (rocuronium or vecuronium). A total of 387 patients were available for analysis. The primary outcome was additional sedation given within 15 minutes following administration of a paralytic agent. The secondary outcome sought to evaluate the incidence of hyperkalemia due to paralytic agents by comparing potassium level before and after paralytic administration. Results: 46.9% of patients who received a short-acting paralytic agent received additional sedation within 15 minutes, compared to 40.9% of patients who received a long-acting paralytic agent. The Chi-square analysis comparing the short and long-acting paralytic groups showed no statistically significant difference (χ² [1, N = 387] = 1.24, P = .266) in the frequency of additional sedation administered. Excluding patients who did not receive any additional sedation, the mean time from paralytic administration to additional sedation in all patients was 20.03 ± 18 minutes. No statistically significant difference was detected between groups regarding changes in potassium level. Conclusion: The use of long-acting paralytic agents was not associated with increased time to administration of sedation compared to shortacting paralytic agents. There is an opportunity to reduce the time to sedation administration for intubated patients receiving both short- and long-acting paralytic agents.
Output feedback sliding mode control based on adaptive sliding mode disturbance observer
Authors: Yunjun Chen , Chao Jiang , Jiuzhi Dong , Zhanshan Zhao
Published: July 2022

In this paper, an adaptive sliding mode disturbance observer is designed to counteract the disturbance actively. By designing the adaptive laws, the assumptions on the disturbance are relaxed in the proposed observer, its first derivative upper bound is considered to be unknown. Based on the proposed disturbance observer, an output feedback sliding mode controller is constructed for the continuous-time linear systems with unknown external disturbance. The proposed controller incorporates only the system output information and has less chattering of the control input. The feasibility of the proposed strategy is shown by numerical simulations.
The Mediating Role of Teacher Identification in the Relationship Between Psychological Distress and Teacher Satisfaction During COVID-19
Authors: Jackson Kyle , Noordien Zorina , Padmanabhanunni Anita , Pretorius Tyrone B.
Published: July 2022

The current study examines the potential mediating role of professional identification of school teachers in the relationship between psychological distress and teaching satisfaction. Professional identification is the extent to which an individual identifies with a professional group, including the values, beliefs, and commitment the individual has in relation to the professional group. Professional identification has been linked to negative work outcomes, such as job performance and turnover intentions, as well as to adverse mental health outcomes. In the context of education, professional identification is the extent to which teachers identify with the teaching profession. Participants (N = 355) were school teachers in South Africa who completed the Center for Epidemiological Depression Scale, the Beck Hopelessness Scale, the Professional Identification Scale, and the Teaching Satisfaction Scale. Structural equation analysis showed that professional identification plays a fully mediational role in the relationship between psychological distress and teaching satisfaction. Interventions that strengthen teachers’ identification with the teaching profession should be considered a priority.
“She Clearly Thought That Something Bad Had Happened to Her”: How Military Lawyers Construct Narratives of Victim Legitimacy and Perceived Harm in Sexual Assault Cases
Authors: Tosto Samantha A. , Bonnes Stephanie
Published: July 2022

It has been well established that survivors of sexual assault are revictimized as they navigate the civilian criminal justice system. Significantly less is known, however, about how sexual violence is navigated within the military justice system. In this study, we use qualitative interviews with military lawyers about sexual assault cases to explore their constructions of victim legitimacy. Lawyers create a distinction between perceived and actual harm done to a victim and perpetuate the notion that victims falsely accuse men of sexual violence. Through these discursive strategies, lawyers suggest that the issue of military sexual violence is inflated. Finally, lawyers blame the institutional structure of the military for teaching victimization to young women. This helps them explain why victims who they do not perceive as legitimate report sexual violence. These findings emphasize the need for further inquiry into how those working in the military justice system perceive and interact with victims.
Challenges in Rear-end Conflict-based Safety Assessment of Highly Disordered Traffic Conditions
Authors: Chauhan Ritvik , Dhamaniya Ashish , Arkatkar Shriniwas
Published: July 2022

Surrogate safety measure (SSM)-based proactive safety assessment in developing economies like India with weak lane discipline mixed traffic conditions is limited and often lacks qualitative aspects of reliability. On further investigation, challenges of data acquisition, the viability of a specific SSM, the corresponding threshold value for the identification of conflict, and availability of reliable road crash data are observed to be the key hurdles in achieving robust results and proposing measures for mitigating rear-end conflicts and risks of crashes. The present study highlights the hurdles in performing the safety assessment for rear-end conflicts in mixed traffic conditions with weak lane discipline and proposes possible measures to overcome these hurdles.
Arterial Signal Offset Optimization Using Crowdsourced Speed Data
Authors: Xia Liang , Li Xiaofeng , Shaon Mohammad Razaur Rahman , Wu Yao-Jan , Jiang Xinguo
Published: July 2022

Signal offset for coordinated traffic signal control is traditionally optimized based on posted speed limit, free-flow speed, or average speed among intersections, without considering the variations of travel speed. Variation in travel speed caused by interference on arterials may lead to inaccurate offset estimation, reducing the efficiency of coordination control. Therefore, this study develops an arterial offset optimization method for traffic signal coordination control using real-time speed collected from high-resolution crowdsourced data. The objective of the proposed method is to minimize the average delay on the corridor. The optimization problem is formulated as integer programming, and a genetic algorithm (GA) is utilized to search for the best offset solution. The proposed method is evaluated on a major arterial (Speedway Boulevard) in Tucson, Arizona. In the numerical exercise, the effectiveness and performance of the proposed method are evaluated in various scenarios, including a scenario with non-recurring congestion. The results show that using high-resolution real-time speed data can reduce travel delay time in a coordinated direction by 32.5% and 17.6% when compared with methods using speed limit and free-flow speed, respectively, and the proposed method is more reliable and robust for handling traffic conditions with varying volume and speed.
Vulnerability Analysis of Casablanca Road Network by Capacity Weighted Spectral Analysis
Authors: Jiang Meilan , Mourabiti Othman El , Miwa Tomio , Morikawa Takayuki
Published: July 2022

The serviceability of a road network often faces challenges of traffic congestion and natural disasters which can damage the performance of many links within the network. To ensure the high performance of a road network, it is essential to identify and protect the critical links which if disrupted will cause substantial damage to the network. This study analyzes the vulnerability of the road network of the city of Casablanca in Morocco. Capacity weighted spectral analysis of the graph Laplacian is used to evaluate the road network vulnerability and identify potential critical links. We consider two cases concerning the weight definition: capacity weighted without considering travel demand and reserve capacity weighted with consideration of travel demand. After finding the critical links of the network, we investigate its vulnerability with consideration of a future tramway project. We compare two cases: the road network with the current tramway lines and that including two additional tramway lines planned for the future. The results show shifts in the critical links between the two cases. Furthermore, an increase in vulnerability is observed after the construction of the new tramway lines if no measures are taken to maintain the corresponding link capacities.
Analysis of Roadway Grade Estimations From Global Positioning Systems and Barometer Measurements
Authors: Pratt Michael P. , Avelar Raul E.
Published: July 2022

Roadway grade is used as an input variable for several highway analysis tasks, including evaluating curve margin-of-safety, applying safety prediction models, assessing the adequacy of sight distance, and maintaining state roadlog databases. However, collecting accurate grade data is often expensive owing to the need to obtain field measurements or review as-built plan sets. Agencies would benefit from the development of a method to compute roadway grade from an automated data collection system. This paper documents a comparison of roadway grade estimations computed from global positioning system (GPS) and barometric altimeter data streams obtained during test drives on highway segments of interest. To calibrate the estimation method, the authors obtained ground-truth grade measurements collected from the field and then modeled those measures as responses in a time series model with the two data stream types as explanatory variables. The authors found that for several applications, the elevation data obtained from GPS were adequate to obtain reasonable estimates, but such estimations could be improved with a supplemental data stream from a barometer.
Effect of fatigue on kinematics, kinetics and muscle activities of lower limbs during gait
Authors: Zhang Li , Yan Yuzhou , Liu Geng , Han Bing , Fei Junhua , Zhang Yunfei
Published: July 2022

Muscle fatigue, as a serious social problem, affects the performance of daily living activities, especially for workers. Decrease of movement control ability caused by muscle fatigue is one of the risk and intrinsic factors for occupational accidents, such as slips, trips, falls, etc. In order to reduce the accident rate and optimize the existing prevention measures, it is necessary to investigate the effect of fatigue on kinematics, kinetics, and muscle activities of human body. In this paper, 26 healthy participants were recruited. The kinematics and kinetics analysis of lower limb joints, and surface electromyograms (sEMG) time-domain and frequency-domain analysis of lower limb periarticular muscles were utilized to investigate the effects of muscle fatigue. The results showed that the fatigue reduced the range-of-motion (RoM) of the lower limb joints. Smaller plantarflexion, knee flexion and hip flexion angles, and greater dorsiflexion angles were observed after fatigue. For the joint moment, the fatigue did not alter the joint moments except for the smaller knee flexion moment. For the joint power, the fatigue decreased the generation power of ankle, knee and hip joint and the absorption power of ankle and knee joints, whereas increased the absorption power of hip joint. Besides, the fatigue increased the normalized integrated sEMG (iEMG) and root-mean-square (RMS) of sEMG, and shifted the median frequency (MF) and mean power frequency (MPF) of sEMG toward lower frequencies. The results from the present study concluded that the muscle fatigue changed the kinematics, kinetics and muscle activities of lower limbs during gait, and then could increase the risk rate of occupational accidents.
Global Gene Expression Regulation Mediated by TGFβ Through H3K9me3 Mark
Authors: Naik Ankit , Dalpatraj Nidhi , Thakur Noopur
Published: July 2022

Background:

Epigenetic alterations play an important part in carcinogenesis. Different biological responses, including cell proliferation, migration, apoptosis, invasion, and senescence, are affected by epigenetic alterations in cancer. In addition, growth factors, such as transforming growth factor beta (TGFβ) are important regulators of tumorigenesis. Our understanding of the interplay between the epigenetic bases of tumorigenesis and growth factor signaling in tumorigenesis is rudimentary. Some studies suggest a link between TGFβ signaling and the heterochromatinizing histone mark H3K9me3. There is evidence for signal-dependent interactions between R-Smads and histone methyltransferases. However, the effects of TGFβ signaling on genome wide H3K9me3 landscape remains unknown. Our research examines TGFβ -induced genome-wide H3K9me3 in prostate cancer.

Method:

Chromatin-Immunoprecipitation followed by sequencing was performed to analyze genome-wide association of H3K9me3 epigenetic mark. DAVID Functional annotation tool was utilized to understand the involvement of different Biological Processes and Molecular Function. MEME-ChIP tool was also used to analyze known and novel DNA-binding motifs.

Results:

H3K9me3 occupancy appears to increase at intronic regions after short-term (6 hours) TGFβ stimulation and at distal intergenic regions during long-term stimulation (24 hours). We also found evidence for a possible association of SLC transporters with H3K9me3 mark in presence of TGFβ during tumorigenesis. No direct correlation was found between the occupancy of H3K9me3 mark and the expression of various genes. The epigenetic mechanisms-mediated regulation of gene expression by TGFβ was concentrated at promoters rich in SRY and FOXJ3 binding sites.

Conclusion:

Our results point toward a positive association of oncogenic function of TGFβ and the H3K9me3 mark and provide a context to the role of H3K9me3 in TGFβ-induced cell migration and cell adhesion. Interestingly, these functions of TGFβ through H3K9me3 mark regulation seem to depend on transcriptional activation in contrast to the conventionally known repressive nature of H3K9me3.
Rosa hybrida Petal Extract Exhibits Antitumor Effects by Abrogating Tumor Progression and Angiogenesis in Bladder Cancer Both In Vivo and In Vitro
Authors: Hwang Byungdoo , Gho Yujeong , Kim Hoon , Lee Sanghyun , Hong Soon Auck , Lee Tae Jin , Myung Soon Chul , Yun Seok-Joong , Choi Yung Hyun , Kim Wun-Jae , Moon Sung-Kwon
Published: July 2022

The edible Rosa hybrida (RH) petal is utilized in functional foods and cosmetics. Although the biological function of RH petal extract is known, mechanism of action studies involving tumor-associated angiogenesis have not yet been reported. Herein, we investigated the regulatory effect of the ethanol extract of RH petal (EERH) on tumor growth and tumor angiogenesis against bladder cancer. EERH treatment inhibited the bladder carcinoma T24 cell and 5637 cell proliferation because of G1-phase cell cycle arrest by inducing p21WAF1 expression and reducing cyclins/CDKs level. EERH regulated signaling pathways differently in both cells. EERH-stimulated suppression of T24 and 5637 cell migration and invasion was associated with the decline in transcription factor-mediated MMP-9 expression. EERH oral administration to xenograft mice reduced tumor growth. Furthermore, no obvious toxicity was observed in acute toxicity test. Decreased CD31 levels in EERH-treated tumor tissues led to examine the angiogenic response. EERH alleviated VEGF-stimulated tube formation and proliferation by downregulating the VEGFR2/eNOS/AKT/ERK1/2 cascade in HUVECs. EERH impeded migration and invasion of VEGF-induced HUVECs, which is attributed to the repressed MMP-2 expression. Suppression of neo-microvessel sprouting, induced by VEGF, was verified by treatment with EERH using the ex vivo aortic ring assay. Finally, kaempferol was identified as the main active compound of EERH. The present study demonstrated that EERH may aid the development of antitumor agents against bladder cancer.
Research on application of knowledge graph for aircraft maintenance
Authors: Yue Siwen , Xiao Le , Li Jiaxin , Wang Nan
Published: July 2022

Aircraft maintenance technology is related to flight safety. It is not only a significant guarantee for the safety of passengers’ lives and property but also an important means for airlines to reduce costs and improve profitability. This paper focuses on aircraft maintenance decision-making, analyzes the current situation and defects of maintenance decision-making, applies knowledge graph technology to this field, and constructs aircraft maintenance knowledge graph; through the character analysis of sample data and experimental comparison, the key factors affecting the accuracy of aircraft maintenance decisions are found; few-shot knowledge reasoning technology is introduced to improve the maintenance strategy reasoning algorithm. In the 737NG aircraft maintenance decision-making system of an airline, the feasibility and effectiveness of the method are verified, which provides strong support for flight safety.
An accurate and stable alternating directional moving particle semi-implicit method for incompressible flow simulation
Authors: Li Date , Zhang Huaixin , Yao Huilan
Published: July 2022

As a Lagrangian mesh free method, Moving Particle Semi-implicit (MPS) method can easily handle complex incompressible flow with free surface. However, some deficiencies of MPS method such as inaccurate results, unphysical pressure oscillation and particle thrust near free surface still required to be further resolved. In this paper, an improved MPS method based on Crank-Nicolson time scheme, named Alternating Direction Moving Particle Semi-implicit (ADMPS) method, is proposed. In addition, a time integral source term (TIS) is developed to suppress unphysical pressure oscillation and a free-surface revise (FR) technique is proposed to avoid particle thrust near free surface. Enhancement of accuracy and stability by these improvements is proved by hydrostatic and dam breaking benchmarks, and the numerical results of the ADMPS-FR-TIS model show good agreement with the hydrostatic analytical solution and the dam breaking experiment data.
Next-generation selective estrogen receptor degraders and other novel endocrine therapies for management of metastatic hormone receptor-positive breast cancer: current and emerging role
Authors: Lloyd Maxwell R. , Wander Seth A. , Hamilton Erika , Razavi Pedram , Bardia Aditya
Published: July 2022

Endocrine therapy (ET) is a pivotal strategy to manage early- and advanced-stage estrogen receptor-positive (ER+) breast cancer. In patients with metastatic breast cancer (MBC), progression of disease inevitably occurs due to the presence of acquired or intrinsic resistance mechanisms. ET resistance can be driven by ligand-independent, ER-mediated signaling that promotes tumor proliferation in the absence of hormone, or ER-independent oncogenic signaling that circumvents endocrine regulated transcription pathways. Estrogen receptor 1 ( ESR1) mutations induce constitutive ER activity and upregulate ER-dependent gene transcription, provoking resistance to estrogen deprivation and aromatase inhibitor therapy. The role ESR1 mutations play in regulating response to other therapies, such as the selective estrogen receptor degrader (SERD) fulvestrant and the available CDK4/6 inhibitors, is less clear. Novel oral SERDs and other next-generation ETs are in clinical development for ER+ breast cancer as single agents and in combination with established targeted therapies. Recent results from the phase III EMERALD trial demonstrated improved outcomes with the oral SERD elacestrant compared to standard anti-estrogen therapies in ER+ MBC after prior progression on ET, and other agents have shown promise in both the laboratory and early-phase clinical trials. In this review, we will discuss the emerging data related to oral SERDs and other novel ET in managing ER+ breast cancer. As clinical data continue to mature on these next-generation ETs, important questions will emerge related to the optimal sequence of therapeutic options and the genomic and molecular landscape of resistance to these agents.
Prospective analysis of factors precluding the initiation of durvalumab from an interim analysis of a phase II trial of S-1 and cisplatin with concurrent thoracic radiotherapy followed by durvalumab for unresectable, locally advanced non-small cell lung cancer in Japan (SAMURAI study)
Authors: Tanzawa Shigeru , Makiguchi Tomonori , Tasaka Sadatomo , Inaba Megumi , Ochiai Ryosuke , Nakamura Junya , Inoue Koji , Kishikawa Takayuki , Nakashima Masanao , Fujiwara Keiichi , Kohyama Tadashi , Ishida Hiroo , Kuyama Shoichi , Miyazawa Naoki , Nakamura Tomomi , Miyawaki Hiroshi , Oda Naohiro , Ishikawa Nobuhisa , Morinaga Ryotaro , Kusaka Kei , Miyamoto Yosuke , Yokoyama Toshihide , Matsumoto Chiaki , Tsuda Takeshi , Ushijima Sunao , Shibata Kazuhiko , Shibayama Takuo , Bessho Akihiro , Kaira Kyoichi , Misumi Toshihiro , Shiraishi Kenshiro , Matsutani Noriyuki , Seki Nobuhiko
Published: July 2022

Background:

The standard of care for unresectable, locally advanced non-small cell lung cancer (LA-NSCLC) is chemoradiotherapy (CRT) followed by durvalumab, based on the PACIFIC trial. Disease progression and pneumonitis were reported as the main reasons to preclude the initiation of durvalumab in multiple retrospective studies. However, the transition rate and the reasons for failure to proceed to consolidation therapy with durvalumab after CRT were not evaluated prospectively. Although phase II studies in Japan have shown high efficacy and tolerability of CRT with cisplatin + S-1 (SP), no prospective study using durvalumab after SP-based CRT has yet been reported. We therefore conducted a phase II study to verify the efficacy and safety of durvalumab following SP-based CRT. In this interim analysis, we report the transition rate and the reasons for its failure.

Methods:

In treatment-naïve LA-NSCLC, cisplatin (60 mg/m2, day 1) and S-1 (80–120 mg/body, days 1–14) were administered with two 4-week cycles with concurrent thoracic radiotherapy (60 Gy) followed by durvalumab every 2 weeks for up to 12 months. The primary endpoint was 12 month progression-free survival rate.

Results:

Fifty-nine patients were enrolled, of whom 86.4% (51/59) proceeded to durvalumab. All of them initiated durvalumab within 42 days after CRT [median 18 days (range: 3–38)], including 27.5% (14/51) in <14 days. Common reasons for failure to proceed to durvalumab were disease progression (2/59, 3.4%) and adverse events (6/59, 10.2%). Among the latter cases, four resumed treatment and proceeded to durvalumab within 42 days on off-protocol. The objective response rate and the disease control rate were 62.7% and 93.2%, respectively. The incidences of ⩾grade 3 pneumonitis, febrile neutropenia, and esophagitis were 0%, 8.5%, and 3.4%, respectively.

Conclusion:

Regarding durvalumab after CRT, this interim analysis of the SAMURAI study clarified the high transition rate, early introduction, and reasons for failure to proceed to consolidation therapy, which were not determined in the PACIFIC trial.

Trial registration:

Japan Registry of Clinical Trials, jRCTs031190127, registered 1 November, 2019, https://jrct.niph.go.jp/latest-detail/jRCTs031190127 .
Sandwich Technique for Large Osteochondral Lesions of the Knee
Authors: Holwein C. , Jungmann P.M. , Suchowierski J. , Gersing A.S. , Wörtler K. , Brucker P.U. , Angele P. , Imhoff A.B. , Vogt S.
Published: July 2022

Objective

To evaluate whether a sandwich technique procedure for large osteochondral lesions (OCL) of the medial femur condyle reduces clinical symptoms and improves activity level as well as to assess repair tissue integration on MRI over 2 years.

Design

Twenty-one patients (median age: 29 years, 18-44 years) who received matrix-associated autologous chondrocyte transplantation (MACT) combined with cancellous bone grafting at the medial femur condyle in a 1-step procedure were prospectively included. Patients were evaluated before surgery (baseline) as well as 3, 6, 12, and 24 months postoperatively, including clinical evaluation, Lysholm score, Tegner Activity Rating Scale, and MRI with Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART) score and a modified Whole-Organ Magnetic Resonance Imaging Score (WORMS).

Results

Seventeen patients were available for the 24-month (final) follow-up (4 dropouts). Lysholm significantly improved from 48 preoperatively stepwise to 95 at final follow-up ( P < 0.05). Tegner improvement from 2.5 at baseline to 4.0 at final follow-up was not significant ( P = 1.0). MOCART score improved significantly and stepwise from 65 at 3 months to 90 at 24 months ( P < 0.05). Total WORMS improved from 14.5 at surgery to 7.0 after 24 months ( P < 0.05). Body mass index and defect size at surgery correlated with total WORMS at final follow-up ( P < 0.05) but did not correlate with clinical scores or defect filling.

Conclusion

MACT combined with cancellous bone grafting at the medial femoral condyle reduces symptoms continuously over 2 years. A 1-step procedure may reduce perioperative morbidity. However, despite improvements, patients’ activity levels remain low, even 2 years after surgery.
Dose-response analysis of aripiprazole in patients with schizophrenia in Taiwan
Authors: Tien Yun , Huang Hsiang-Ping , Liao Ding-Lieh , Huang Shang-Chien
Published: July 2022

Background:

Aripiprazole is a third-generation antipsychotic agent with acceptable efficacy and a good safety profile. Previous studies have indicated the therapeutic serum concentration of aripiprazole to be 100 to 350 ng/ml; however, most of these studies examined a Western population. Patients with schizophrenia from Tungs’ Taichung MetroHarbor Hospital in central Taiwan were recruited to analyze the dose–response relationship of aripiprazole in the Chinese population.

Objective:

We aimed to investigate whether a serum concentration of aripiprazole higher than the current suggested range leads to higher response rates.

Design:

A prospective cohort study was designed to investigate the response rates in different studied cohorts grouped by serum concentration of aripiprazole.

Data Sources and Methods:

Data of 64 patients who presented to a single medical center in central Taiwan and who received therapeutic drug monitoring (TDM) were obtained. Serum concentrations of aripiprazole were correlated with the clinical response of patients by using the Clinical Global Impressions (CGI) scores.

Results:

The mean concentration of aripiprazole was 432.1 ± 275.1 ng/ml in the study cohort. Among the much-improved patients, the mean serum concentration of aripiprazole was 494 ± 273 ng/ml (25th–75th percentiles 264–666 ng/ml), which was higher than the current recommended therapeutic target of 100–350 ng/ml for aripiprazole. The response rate in the severe group (baseline CGI score of 6 or 7) was significantly higher than in the moderate group (baseline CGI score of 4 or 5; 86.7% versus 55.9%, p = 0.007).

Conclusion:

A significantly higher response rate was observed in the study cohort with serum aripiprazole concentrations over 300 ng/ml. Therefore, dosing higher than the current recommended range may potentially improve the treatment efficacy in the Chinese population. Because the serum concentration varies among patients due to multiple intrinsic and extrinsic factors, TDM, especially in outpatients, is recommended if the clinical response is limited.
“We Rewrote This Title”: How News Headlines Are Remediated on Facebook and How This Affects Engagement
Authors: Lamot Kenza , Kreutz Tim , Opgenhaffen Michaël
Published: July 2022

Social media have become a very important news platform, both for the presentation and consumption of news by social media users. News is therefore eagerly shared by news media on platforms such as Facebook, Instagram, and Twitter in the hope of reaching as many news consumers as possible. In this highly competitive media landscape, news media aim to attract consumer attention to these news stories by incorporating the social media logic into their reporting. In this study, we focus specifically on the conversion and accompanying adaptations of news originating from online news sites to the Facebook page of a news medium, with a focus on the (re)formulation of the headline that functions as an important element in both online news articles and Facebook posts. Based on computational analysis, we compare the headlines of news items on the news outlet’s website to the headlines published on Facebook and link these with the user engagement metrics ( N = 10,579). The findings revealed that the routine of rewriting or adapting headlines on Facebook in contemporary journalism is rather common and that this rewriting is done with an eye toward injecting elements that better align with the social media logic, consequently magnifying its impact on engagement.
The fabrication of halloysite nanotube-based multicomponent hydrogel scaffolds for bone healing
Authors: Same Saeideh , Kadkhoda Jamileh , Navidi Golnaz , Abedi Fatemeh , Aghazadeh Marziyeh , Milani Morteza , Akbarzadeh Abolfazl , Davaran Soodabeh
Published: July 2022

Bone tissue engineering, as an alternative for common available therapeutic approaches, has been developed to focus on reconstructing of the missing tissues and restoring their functionality. In this work, three-dimensional (3D) nanocomposite scaffolds of polycaprolactone-polyethylene glycol-polycaprolactone/gelatin (PCEC/Gel) were prepared by freeze-drying method. Biocompatible nanohydroxyapatite (nHA), iron oxide nanoparticle (Fe3O4) and halloysite nanotube (HNT) powders were added to the polymer matrix aiming to combine the osteogenic activity of nHA or Fe3O4 with high mechanical strength of HNT. The scanning electron microscope (SEM) methods was utilized to characterize the nanotube morphology of HNT as well as nanoparticles of Fe3O4 and nHA. Prepared scaffolds were characterized via Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), and SEM methods. In addition, the physical behavior of scaffolds was evaluated to explore the influence of HNT on the physicochemical properties of composites. Cell viability and attachment were investigated by MTT (3-(4,5-dimethylthiazol-2-yl)−2,5-diphenyl-2H-tetrazolium bromide) assay and SEM on human dental pulp-derived mesenchymal stem cells (h-DPSCs) in-vitro. Cell proliferation was observed without any cytotoxicity effect on h-DPSCs for all examined scaffolds. Alizarin red (ARS) and alkaline phosphatase (ALP) staining were carried out to determine the osteoconductivity of scaffolds. The data demonstrated that all PCEC/Gel/HNT hydrogel scaffolds supported osteoblast differentiation of hDPSCs with moderate effects on cell proliferation. Moreover, PCEC/Gel/HNT/nHA with proper mechanical strength showed better biological activity compared to PCEC/Gel/HNT/Fe3O4 and PCEC/Gel/HNT scaffolds. Therefore, this study suggested that with proper fillers content, PCEC/Gel/HNT nanocomposite hydrogels alone or in a complex with nHA, Fe3O4 could be a suitable candidate for hard tissue regeneration.
A Rare Case of Granulomatous Interstitial Nephritis in a Patient With COVID-19
Authors: Alotaibi Manal , Ellis Carla , Wadhwani Shikha , Peleg Yonatan
Published: July 2022

Acute kidney injury (AKI) in patients with coronavirus disease 2019 (COVID-19) is common, especially among severely ill patients. While acute tubular necrosis (ATN) is one of the most common findings in published kidney biopsy series for patients with COVID-19 infections, a number of glomerular pathologies have been described as well. Among glomerular pathologies in COVID-19, COVID-19-Associated Collapsing Glomerulopathy (COVAN) remains the most common pattern of injury. Patients with 2 high-risk APOL1 alleles appear to be at increased risk for COVAN, similar to other forms of collapsing glomerulopathy such as HIV-Associated Nephropathy. Acute interstitial nephritis (AIN) is a less common finding in patients with COVID-19 and reported cases have been mild. Reports of a subtype of AIN, granulomatous interstitial nephritis (GIN), among COVID-19 patients are extremely rare and have not been reported in association with COVAN. Here, we report a case of COVAN associated with severe GIN.