bluuebunny/crossref_metadata_2025 huggingface dataset:
THE APPLICATION OF STATISTICAL METHODS IN EVALUATING THE RESULTS OF CLINICAL FINDINGS OF THE DRUG BOVHUALONIDASE AZOXIMER IN CATS WITH UROLOGICAL DISEASES
Authors:   FSBEI HE Saint Petersburg state university of veterinary medicine, Nazarova А. V. , Semenov B. S. ,   FSBEI HE Saint Petersburg state university of veterinary medicine, Kuznetsova Т. Sh. ,   FSBEI HE Saint Petersburg state university of veterinary medicine
Published: January 2021

In the period from November 2018 to August 2020, we conducted a randomized blind placebo-controlled confirmatory clinical trial in parallel groups on the basis of network of veterinary clinics in Saint Petersburg and Saint Petersburg state university of veterinary medicine. The purpose of the study: to evaluate the effectiveness of Bovhualonidaze azoximer(BA) in patients subjected to surgical intervention on the urethra and bladder, to prevent postoperative complications and relapses of the underlying disease. The frequency of complications was taken as an indicator of effectiveness. 80 cats were evaluated according to the criteria for inclusion in the study, after evaluation and randomization, 53 patients (24 and 29 cats in the experimental and control groups, respectively) who had indications for surgery on the urethra and/or bladder were included in the study. After the withdrawal of some patients, 38 cats were analyzed (17 and 23 cats in the experimental and control groups, respectively). Animals in the experimental group received BA drugs in addition to conventional therapy, and animals in the control group received placebo. The rate of complications in the experimental group was 11.8 %, in the control group-61.9 %. The relative risk was 19.0 %, and the relative risk reduction was 80.9 %. The chance of developing complications in the animals of the experimental group is 12.2 times lower than in animals of the control group.. Absolute risk reduction — 50.1 %, and the number of patients to be treated — 2 patients. The confidence interval for the risk of side effects of BA drugs in cats was 0.0-10.1 %. Based on the results of our clinical study, we proved that the use of BA drugs is effective for preventing complications during surgical interventions on the urethra and bladder, and the risk of side effects when using BA drugs in cats is insignificant
MEAT PRODUCTIVITY OF CROSSBREEDS WHEN CROSSING BESTUZHEV BREED WITH CHARILAIS BREED
Authors:   FSBEI HE Ulyanovsk SAU, Stenkin N. I.
Published: January 2021

The article presents the results of research on fattening and meat qualities of bestuzhev-charolaise crossbreeds (bulls) of various bloodlines. At the same time, bulls of the II generation (ӏӏӏ group) had the highest average daily growth (1085g), respectively, absolute (216kg) and relative growth (59.34%). In animals of the same group, less feed was spent on 1 kg of growth (6.3 feed units) and the best payment for feed was made with an increase (14.49 kg). All of these indicators of crossbred bulls of I and III generation (II and IV groups) also exceed bestuzhev purebred bulls, but inferior to the hybrids of II generation (III group). The results of the control slaughter, carried out at the age of 15 months, compared with the pure breed Bestuzhev cattle weight more carcasses crossbred bulls in all three groups have more carcasses, but the hybrid animals have the greatest III generation, then II generation ( III group) and I generation. Economic indicators of growing and fattening bestuzhev-charolaise bulls of different blood types showed that with an increase in blood content for the charolaise breed, the profit per 1 animal sold increases and the level of profitability of beef production increases in comparison with purebred Bestuzhev animals. Therefore, crossing a half-breed bestuzhevskih heifers with bulls Charolais to II and III generation economically feasible. Using this method of crossing will allow farms in the Middle Volga region to significantly increase the production of beef and improve its quality.
ANALYSIS OF THE FATTY ACID COMPOSITION OF COW’S MILK AGAINST THE BACKGROUND OF MODIFIED DIATOMITE ADDITIVES
Authors:   FSBEI HE Ulyanovsk SAU, Akhmetova V. V. , Merchina S. V. ,   FSBEI HE Ulyanovsk SAU, Mukhitov А.Z. ,   FSBEI HE Ulyanovsk SAU
Published: January 2021

The article presents the results of studying the effect of modified diatomite as part of a complex additive at the ratio of saturated and unsaturated fatty acids in cow’s milk. Production and physiological tests were carried out on the basis of a dairy farm LLC “Agrofirma Tetyushskoe” in the Ulyanovsk region on black-and-white cows of 2...3 lactation. For the physiological experiment, animals were selected by the method of analogues by live weight, number and month of lactation, pregnancy, and physiological state. The complex additive included modified diatomite, diacetophenonyl selenide containing organic selenium (DAFS), sunflower oil, and feed yeast. Additive based on 250 g/head/day mixed with feed once a day was administered in the diet of animals of the experimental group, the other group was a control and received no additive. The additive had an effect on the fatty acid composition of milk and contributed to an increase in the fraction of saturated fatty acids with a short chain. In the fat fraction, the amount of saturated short-chain fatty acids increases by 4.0% due to an increase in the content of capric (by 6.7%), lauric (by 12.3%, P<0.05), myristic (by 13.3%, P<0.05), palmitic (by 17.1%, P<0.05), which is a positive factor and indicates an active synthesis of volatile fatty acids, primarily acetate and 3-hydroxybutyrate. At the same time, there was a sharp decline in the content of stearic (27.3%, P<0.05) and arachinic (27.6%, P<0.05) acids. The milk of cows in the experimental group showed a decrease in the level of monounsaturated fatty acids by 7.4%.
PASSPRO SOY FEED PRODUCT IN THE DIETS OF NEWLY CALVED HIGHLY PRODUCTIVE COWS
Authors:   FSBSI Krasnodar scientific center for animal science and veterinary medicine, Chuprina Е.G. , Yurin D. А. ,   FSBSI Krasnodar scientific center for animal science and veterinary medicine, Yurina N.А. ,   FSBSI Krasnodar scientific center for animal science and veterinary medicine
Published: January 2021

Studies conducted in farm conditions, the company, OOO PZ «Nasha Rodina» in Sokolovsky village of Gulkevichsky district of Krasnodar region. The aim of the research was to study the use of the PassPro Soy feed product consisting of protected soy protein in the diets of new-bodied highly productive cows. 2 groups of cows of the red-mottled Holstein breed were formed, selected according to the principle of pairs-analogues: by age in calving, calving time, live weight, productivity for the past lactation, fat and protein content in milk. The ration of the first control group was the ration accepted on the farm for newbodied cows. The diet of the second experimental group was the same as in the first control group, only 1.5 kg of compound feed was replaced with 1.5 kg of PassPro Soy, which is a protected soy protein in the form of a 5 mm granule. During the milking period, the daily milk yield of cows in the control group was 30.80±1.07 kg. The daily milk yield of cows of the second group, where 1.5 kg of compound feed was replaced by 1.5 kg of PassPro Soy, significantly increased by 6.6 %. Due to the increase in the gross milk yield, there is a tendency to increase the amount of milk fat in the milk of cows of the second group by 6.9 %, as well as milk protein by 11.3 %. In the experimental group, when replacing 1.5 kg of feed taken on the farm with 1.5 kg of PassPro Soy, milk productivity increased by 2.03 kg. Additional profit from the sale of milk in the experimental group increased by 48.72 rubles. for 1 head per day. The economic efficiency in the second experimental group was 6.30 %.
THE GENESIS OF METABOLIC ENERGY USE IN THE LACTATION FUNCTION OF COWS OF DIFFERENT AGES AND PRODUCTIVITY
Authors:   FSBEI HE Ulyanovsk SAU, Mokhov B.P.
Published: January 2021

The formation and development of lactation function as an integral process of reproduction concerns all systems of the whole organism. The influence of heredity and expression of a trait under the influence of the environment determines the individuality and synergy of traits that determine milk productivity. Thermal conductivity, intracellular cyclosis, membrane potential, neuro-hormonal signals, blood and lymph are the main ways of communication and mutual influence of these signs. The nutrition system is most important for lactation function. Nutrients divided during digestion into amino acids, monosaccharides, fatty acids, and other elementary parts are delivered to the breast cells, where they become a substrate for the enzymatic synthesis of milk. Circadian changes in life processes and, first of all, feed intake reactions determine the circadian frequency of feed intake and the intake of nutrients into the organism. This affects the concentration of the intracellular substrate, the activity of enzymes and the thermal state of the whole organism. For life, as the highest form of existence of matter, thermal energy is particularly important. It not only connects the actions and interactions of all types of matter, it creates order from the chaotic movements of discrete heat sources, determining the measure of irreversible energy dissipation, entropy, and the gradient of changes in the metabolic processes of “outflow and inflow of energy”, the state of saturation and nutrient deficiency. The article is based on convergence, biophysical, ethological and animal sciences. Using the Joule as a single estimate of energy consumption and work performed (milk production) increases the scientific reliability of the research.
REPRODUCTIVE QUALITIES OF MINKS WITH THE USE OF VETERINARY PREPARATIONS
Authors:   FSBEI HE Izhevsk state agricultural academy, Pushkarev М. G , Krasnova О. А. ,   FSBEI HE Izhevsk state agricultural academy
Published: January 2021

Animal husbandry of Udmurtia is represented by several animal farms that have high rates of business output of young animals - 5.43-5.77 puppies per main female, which is higher than the average for animal husbandry farms in Russia. The aim of the research was to study the effectiveness of use of various preparartions in improving the reproductive qualities of minks and vital activity of their offspring. When conducting research, it was offered to use a complex of preparations. The first group of females received gonadotropin horiogonin and «Purevitin», and the second veterinary preparation «Lyutragon» and «Purevitin». The control group only hormone horiogonin. The results showed that the number of successfully foaled females of the first and second groups is greater than in the control by 10.5 and 21.0%, respectively. The fertility of minks of the second experimental group was 5.83 heads, which is 14% more than in the control analogues. Safety in the 1st and 2nd experimental groups was higher by 8.1 and 12.2 percentage points compared to the control analogues, respectively. The business output of young animals, taking into account the safety in the 2nd group, was 5.71 goals, 263 puppies were raised for slaughter, and in the first experimental group - 5.4 and 227 goals, respectively. The rate of business output of young animals in the control group was lower by 23 and 29% compared to the first and second experimental groups, respectively. Thus, when breeding mink to stimulate and improve the natural resistance of organism, the reproductive qualities of females during the rut, increasing the yield of young animals and its safety it is advisable to include a mixture of preparations hormone «Lutragon» and «Purevitin», promoting increase of profitability of up to 110 %.
USE OF LEGUMES FOR ECOLOGICAL RECLAMATION OF STEPPE DEGRADED PASTURES OF KULUNDA
Authors:   Altai state university, Mikhalev Е. V. , Silantyeva М. М. ,   Altai state university
Published: January 2021

Intensive development of the steppe communities of Kulunda, located in the southern part of the West Siberian lowland in the XX century led to a significant anthropogenic transformation of all steppe ecosystems. Representatives of the legume family, which is the most important component of steppe grasses, have almost disappeared from the grasslands. The research was conducted on the territory of the Mikhailovsky district of the Altai territory, on the lands of LLC KKH «Partner» in the environs of Poluyamki village scince 2013-till present days climatic conditions of dry steppe zone of Western Kulunda. The aim of the work was to evaluate representatives of the legume family for ecological reclamation of Kulunda steppe pastures. The experiment was performed on 2 degraded fenced steppe areas (10 x 10 m) corresponding to the third stage of pasture digression. Winter sowing of legumes was carried out: cicer milk vetch (Astragalus cicer L.), sainfoin milk vetch (A. onobrychis L.), furrowed milk vetch (A. sulcatus L.), bird’s foot trefoil (Lotus corniculatus L.), sickle alfalfa (Medicago falcata L.), hop alfalfa (M. lupulina L.) and late spring sowing: cicer milk vetch and sainfoin, bird’s foot trefoil by tapping into the sod. Monthly growth dynamics of sown plants (number of shoots per m2, height, phenology) was recorded, and the feed value of aboveground biomass was established. It was found that the drought-resistant species of alfalfa sickle has a significant biomass, is short-lived in the grass stand and requires re-sowing every 4 years. Hop alfalfa is recommended for improving degraded pastures, but due to its short ontogeny, it needs to be re-sown every three years. Among milk vetches, sainfoil milk vetch is the most promising – a long-rooted, rod-rooted polycarpic that increases its area due to numerous underground rhizomes. The greatest nutritional and energy value was possessed by the phytomass of bird’s foot trefoil and sickle alfalfa.
COBALT AND CADMIUM CONTENT IN PLANT TISSUES OF TECHNOGENIC ZONE
Authors:   FSBEI HE Orenburg state medical university, Nemereshina О. N. , Petrova G. V ,   FSBEI HE Orenburg state agrarian university, Filippova А. V. ,   FSBEI HE Orenburg state agrarian university
Published: January 2021

The collection of heavy metals in soils is a threat to public health and agriculture. Wild and cultivated plants are able to accumulate significant amounts of heavy metals, which on the one hand allows the use of phytopreparations to correct microelement exchange and eliminate hypomicroelementosis. The work shows the results of study of the content of cobalt and cadmium in wastewater, soil and the aboveground part of medicinal and forage plants in the fields of wastewater irrigation located in the sanitary protection zone of Orenburg gas processing plant. 9 types of plants used in medical and veterinary practice in Russia were selected for the study. Water, soil, and plant samples were collected at the end of June from 2018 to 2020. The TM content was determined on the basis of the interdepartmental complex analytical laboratory of FSBEI HE «Orenburg state agrarian university» by atomic absorption spectroscopy using the «Spektr-5» atomic absorption spectrometer (Russia). The ability of species to accumulate cadmium and cobalt in the aboveground part (assimilating and generative organs) was determined. According to the results of the research, the ability of the studied plants to control to a certain extent the intake of cobalt and cadmium from the environment to generative and assimilating organs is seen. Specific differences in the nature of accumulation of cobalt and cadmium in the aboveground part of the studied plants were determined. The results of the study may be of interest for planning enterprises for phytoremediation of technogenically polluted soils and evaluating the quality of medicinal and feed plant raw materials.
A studio experience for new building design in Sivas Höllüklük Street
Authors: Koç Pınar , Tuztaşı Uğur
Published: January 2021

The aim of the study is to develop new design insights with regard to a new building in the historical environment of Sivas in Central Turkey. For this purpose, traditional houses located on a main road known as Hollukluk Street in Sivas have been chosen as the study area and a method focusing on the concept of reference is applied within a studio setting. Consequently, design insights have been developed by analysing the study area on mass organisation, spatial organisation, frontal texture, tectonic fiction and compactness relations in terms of street texture. In this practice, it has been observed that the students tend to refer to the entrance axis as a design guide, use the horizontal and vertical lines of the mass and refer to the new design with reference to the tectonic components. The outputs of the studio are formed in terms of four design insights which are shared in the findings section. As a result, design information produced from context-defined practice was used as the constituent elements of the formal structure in the new building, and these also contributed to the improvement of the street silhouette within the existing built environment.
 
Keywords: Architectural studio, design, historical environment of Sivas, new building.
Intuition in music education
Authors: Kirliauskienė Rasa , Abramauskienė Jolanta
Published: January 2021

This article analysed the role of intuition in music education. Since success needs insight and quick perception, otherwise called intuition, this article aimed to reveal how it is possible to achieve music teacher’s activity. Also, the content of the role of a contemporary music teacher was identified and five aspects were distinguished: significance as an educator and as an authority, the importance of teacher’s personality, creativity and value-based aspects. The research content of the role of a contemporary music teacher justifies the possibilities for intuition in music education and extends its boundaries. The content of the role of a contemporary music teacher revealed during the research substantiates possibilities of intuition in music education and expands its boundaries. The analysis of the research results is meaningful for the improvement of music education.
 
Keywords: Music education, the role of a contemporary music teacher, intuition.
Social Determinants of Emergency Department Visits among Persons Diagnosed with Coronary Heart Disease and Stroke
Authors: Baptiste Diana-Lyn , Turkson-Ocran Ruth-Alma , Han Hae-Ra , Dennison Himmelfarb Cheryl , Commodore-Mensah Yvonne
Published: January 2021

Background: Social determinants of health (SDOH) are associated with a variety of health outcomes, yet their relation to emer­gency department (ED) visits among individu­als with coronary heart disease (CHD) or stroke is unclear.Objective: We examined whether SDOH were associated with ≥1 ED visit among persons diagnosed with CHD or stroke.Methods: We performed a cross-sectional analysis of the 2010-2018 National Health Interview Survey, examining ED visits among individuals who self-reported CHD or stroke diagnosis. The outcome was defined as re­porting ≥1 ED visit in the previous 12 months vs none. The SDOH examined were race, employment status, poverty, insurance status, marital status, and educational status.Results: We included N=14,925 partici­pants with a diagnosis of CHD or stroke. The mean (±SD) age was 68 (±.14) years. After adjusting for age and sex, non-Hispanic Blacks were more likely (adjusted odds ratio [AOR]: 1.29; 95%CI: 1.15-1.44) to report having ≥1 ED visits than Whites. Compared with Whites, Asians had lower odds of having ≥1 ED visit in the previous 12 months (AOR: .63, 95%CI: .49-.82). Those who were unmarried (AOR: 1.21, 95%CI: 1.12 – 1.31), unemployed (AOR: 1.53, 95%CI: 1.36- 1.72) and had a poverty income ratio of <1 (AOR: 1.47, 95%CI: 1.31-1.67) had higher odds of having ≥1 ED visits.Conclusion: Being Black, unmarried, unem­ployed, and having lower income levels were associated with a higher likelihood of having ≥1 ED visits in the prior 12 months among individuals with a CHD or stroke diagnosis. SDOH should be considered when devel­oping systematic interventions to prevent costly ED visits.Ethn Dis. 2021;31(1):41-46; doi:10.18865/ed.31.1.41
Diabetes-Related Stigma and its Influence on Social Networks, Social Support, and HbA1c in Ghana
Authors: Botchway Marian , Davis Rachel E. , Merchant Anwar T. , Appiah Lambert T. , Moore Spencer
Published: January 2021

Objective: We applied a social network approach to examine if three types of diabetes-related stigma (self-stigma, per­ceived stigma and enacted stigma) moder­ated associations between social network characteristics (network size, kin composi­tion, household composition, and network density), social support, and blood glucose among Ghanaians with type 2 diabetes mel­litus (T2DM).Methods: Data were obtained through a cross-sectional survey of 254 adults at a diabetes clinic in Ghana that assessed participants’ social networks, social support, and frequency of experiencing three types of diabetes-related stigma.Results: Self-stigma moderated associa­tions between kin composition and social support when controlling for network size (β=-.97, P=.004). Among study participants reporting low self-stigma, kin composition was positively associated with social support (β=1.29, P<.0001), but this association was not found among those reporting high self-stigma. Network size was positively associ­ated with social support among participants reporting both low and high self-stigma. None of the types of diabetes-related stigma moderated other associations between social networks, social support, and blood glucose.Conclusions: Individuals with T2DM who report high self-stigma may have lower social support, which can reduce their capacity for disease management. Addition­ally, larger social networks may be beneficial for individuals with T2DM in countries like Ghana, and interventions that expand network resources may facilitate diabe­tes control. Ethn Dis.2020; 31(1):57-66; doi:10.18865/ed.31.1.57
Disparities in ADHD Diagnosis and Treatment by Race/Ethnicity in Youth Receiving Kentucky Medicaid in 2017
Authors: Winders Davis Deborah , Jawad Kahir , Feygin Yana , Creel Liza , Kong Maiying , Sun JingChao , Lohr W. David , Williams P. Gail , Le Jennifer , Jones V. Faye , Trace Marie , Pasquenza Natalie
Published: January 2021

Background: Kentucky has among the highest rate of attention deficit/hyperactivity disorder (ADHD) and stimulant use in the United States. Little is known about this use by race/ethnicity and geography. This article describes patterns of diagnosis of ADHD and receipt of stimulants and psychosocial interventions for children aged 6-17 years receiving Kentucky Medicaid in 2017 and identifies factors associated with diagnosis and treatment.Methods: Using Medicaid claims, children with and without ADHD (ICD-10 codes F90.0, F90.1, F90.2, F90.8, and F90.9) were compared and predictors of diag­nosis and treatment type were examined. Psychosocial interventions were defined as having at least one relevant CPT code. Chi-squared tests and logistic regression models were used for univariate and multivariable analysis, respectively.Results: The rates of ADHD, stimulant use, and psychosocial interventions in our study population exceeded the national aver­age (14% vs 9%; 75% vs 65.5%; and 51% vs 46.5%, respectively). The distributions varied by sex, race/ethnicity, sex among race/ethnicities, and population density. In general, race/ethnicity predicted ADHD diagnosis, stimulant use, and receipt of psy­chosocial interventions with non-Hispanic White children being more likely to receive diagnosis and medication, but less likely to receive psychosocial therapy than other children. Differences were also shown for rural compared with urban residence, sex, and sex within racial/ethnic groups.Conclusions: Diagnosis and treatment modalities differed for children by race/ ethnicity, population density, and sex. More data are needed to better understand whether differences are due to provider bias, child characteristics, or cultural varia­tions impacting the utilization of different treatment options.Ethn Dis. 2021;31(1):67- 76; doi:10.18865/ed.31.1.67
Native American Ancestry and Air Pollution Interact to Impact Bronchodilator Response in Puerto Rican Children with Asthma
Authors: Contreras Maria , Keys Kevin , Magana Joaquin , Goddard Page , Risse-Adams Oona , Zeiger Andrew M. , Mak Angel C.Y. , Samedy-Bates Lesly-Anne , Neophytou Andreas , Lee Eunice , Thakur Neeta , Elhawary Jennifer R. , Hu Donglei , Huntsman Scott , Eng Celeste , Hu Ting , Burchard Esteban G. , White Marquitta J.
Published: January 2021

Objective: Asthma is the most common chronic disease in children. Short-acting bronchodilator medications are the most commonly prescribed asthma treatment worldwide, regardless of disease severity. Puerto Rican children display the high­est asthma morbidity and mortality of any US population. Alarmingly, Puerto Rican children with asthma display poor broncho­dilator drug response (BDR). Reduced BDR may explain, in part, the increased asthma morbidity and mortality observed in Puerto Rican children with asthma. Gene-environ­ment interactions may explain a portion of the heritability of BDR. We aimed to identify gene-environment interactions as­sociated with BDR in Puerto Rican children with asthma.Setting: Genetic, environmental, and psycho-social data from the Genes-environ­ments and Admixture in Latino Americans (GALA II) case-control study.Participants: Our discovery dataset con­sisted of 658 Puerto Rican children with asthma; our replication dataset consisted of 514 Mexican American children with asthma.Main Outcomes Measures: We assessed the association of pairwise interaction mod­els with BDR using ViSEN (Visualization of Statistical Epistasis Networks).Results: We identified a non-linear interac­tion between Native American genetic ancestry and air pollution significantly as­sociated with BDR in Puerto Rican children with asthma. This interaction was robust to adjustment for age and sex but was not significantly associated with BDR in our replication population.Conclusions: Decreased Native American ancestry coupled with increased air pollu­tion exposure was associated with increased BDR in Puerto Rican children with asthma. Our study acknowledges BDR’s phenotypic complexity, and emphasizes the importance of integrating social, environmental, and bi­ological data to further our understanding of complex disease.Ethn Dis. 2021;31(1):77- 88; doi:10.18865/ed.31.1.77
Oral Sucrose for Neonatal Pain: Perception of Jordanian Nurses
Authors: Kassab Manal , Joseph Rachel , Alhammad Nancy , Mohammad Khitam I
Published: January 2021

Background

Neonatal pain management using sucrose has been an established practice in Western countries. However, in the developing world, the practice is still not widely accepted. Neonatal nurses' perceptions about the neonatal pain experience and efficacy of oral sucrose may influence that decision.

Purpose

To investigate Jordanian neonatal nurses' perceptions about the use of oral sucrose for neonatal pain.

Design and Sample

A cross-sectional descriptive design was used to collect data from 191 neonatal nurses working in 3 different hospital settings in northern and middle central Jordan.

Main Outcome Variables

Knowledge and perception of Jordanian nurses about neonatal pain and oral sucrose and their relationship to demographic variables.

Results

More than half of nurses had knowledge deficit about pain management. Fifty-five percent of the nurses had a positive perception toward pain assessment tools, and the majority indicated positive opinion toward oral sucrose usage. Demographic factors can impact their perceptions.
Neonatal Continuing Education That Powers Family-Centered Care Like Never Before
Authors: Discenza Deborah
Published: January 2021

Families in the NICU struggle on a daily basis and they are at high risk for mental health challenges ongoing due to the trauma inflicted at birth and during the NICU and beyond. Starting parents down a path of psychosocial support is key at bedside and can have a major impact on that infant and family's long-term outcomes. This is the most powerful family-centered care program in existence thanks to the collaboration of three well-respected organizations—National Perinatal Association, NICU Parent Network, and Patient + Family Care.
Basic Approach to Reading a Radiograph in the Neonate
Authors: Whalen Mary
Published: January 2021

The radiograph is a cost-effective and minimally invasive testing mechanism used to assist clinicians in the diagnosis of many diseases that affect the newborn. However, radiographic interpretations can differ between radiologists and clinicians. The interpretation of findings is most accurate when considered in the context of the patient's clinical presentation, symptoms, and test results. This column presents readers with a basic approach to reading a radiograph as well as a guide to interpreting both chest and abdominal x-rays.
Semântica, Pragmática e Sintaxe Formais
Authors: Conde Dirceu Cleber , Basso Renato Miguel
Published: January 2021

O dossiê “Semântica, Pragmática e Sintaxe Formais” reúne trabalhos que versam sobre fenômenos linguísticos no âmbito de abordagens formais, com ênfase no significado e na estrutura de expressões e construções linguísticas. Alguns dos trabalhos que pertencem a este dossiê foram apresentados no III Colóquio de Semântica Referencial (III CSR), que aconteceu em agosto de 2019, na Universidade Federal de São Carlos (UFSCar), e que teve como convidada a professora Veneeta Dayal, da Universidade de Yale.
Incidence of Emergence Agitation in Pediatric Patient after General Anesthesia
Authors: Andriyanto Lucky , Utariani Arie , Hanindito Elizeus , Santoso Kohar Hari Santoso Hari , Hamzah Hamzah , Puspita Eka Ari
Published: January 2021

Post anesthesia agitation is common problem in pediatric post anesthesia care unit. The incidences range from 10 to 80%. EA has been described as a dissociated state of consciousness in which the child is inconsolable, irritable, and uncooperative typically thrashing, crying, moaning or incoherent. This study was done to determine the incidence of emergence agitation and associated risk factors in pediatric patients who underwent general anesthesia. This descriptive and analytic study was performed on 105 pediatric patient aged 1-12 years that underwent general anesthesia for various elective diagnostic and surgeries at Dr. Soetomo Hospital between January and February 2016. The presence of emergence agitation was recorded using Pediatric Anesthesia Emergence Delirium (PAED) scale. The factors that linked with Emergence Agitation were recorded in a questionnaire. The data were analyzed using SPSS software with logistic regression. p - values less than 0.05 were considered as significant. Forty two (40%) children had Emergence Agitation. Preoperative anxiety (p = 0.006) and Pain (p=0.035) were associated with higher rates of post anesthetic emergence agitation. This study identified preoperative anxiety and pain as risk factors, which are associated with emergence agitation in children. To minimize the incidence of post anesthetic emergence agitation, these risk factors should be considered in the routine care by anesthetist.
Lactate Level as a Prediction Factor of Reperforation after Repairing Gastric Perforation
Authors: Budipramana Vicky Sumarki
Published: January 2021

Reperforation after gastric perforation repair is a complication which increases the rate of morbidity and mortality in gastric perforation. The lack of ability of the tissue to use oxygen in septic condition causes anaerobic cellular metabolism and furthermore it will cause failure in closing the perforation. The production of anaerobic metabolism is lactic acid which can be measured from the blood. The aim of this study is to determine the cut-off point of blood lactate level as a predictor of reperforation after repairing gastric perforation. Forty-six patients diagnosed as gastric perforation, who were repaired in Dr Soetomo Hospital from October 2014 to October 2015 were recruited as samples. Serum lactate was taken one hour before repairing the perforation. After being repaired, the patients were observed until the 14th day to evaluate whether any reperforation would occur or not . The design of this research was cross-sectional, analytic observational. The data was analyzed using independent t-test and ROC for obtaining the cut-off point as a predictor of the reperforation after the gastric perforation was repaired. There was a significant difference in the mean of lactate level in the group with reperforation compared with that of the non-reperforation group, that is as big as 3.74±0.59 mmol/L and 2.60±0.76 mmol/L. Using ROC curve analysis, there was the cut-off point of lactate level for reperforation 3.35 mmol/L, with sensitivity 92.9%, specificity 84.4%, positive predictive value 72% and negative predictive Value 96.4%, accuracy 87.0% and in the AUC value 0.902.
Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation
Authors: Isyroqiyyah Nur Moya , Soegiarto Gatot , Setiawati Yuani
Published: January 2021

Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological function. Drug hypersensitivity is common and may cause emergency condition until death. The incidence of drug hypersensitivity-related hospitalizations has usually been assessed within hospitals. The aim of this study is to determine the profile of drug hypersensitivity patients hospitalized at Dr. Soetomo Hospital in 6 months period from January to June 2016. This study was a descriptive retrospective study on medical records of drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital in 6 months period. The patient’s demographic data, the type of hypersensitivity reaction, and the final outcome of the hospitalization were collected. Within the 6 months period, there were 16 drug hypersensitivity patients hospitalized in Dr. Soetomo Hospital. Most of them are female (56.25%), and aged between 46-55 years (25%). There were 4 patients (25%) with type I hypersensitivity: urticaria, angioedema and anaphylaxis; while type IV hypersensitivity occured in 12 patients (75%): Stevens-Johnson syndrome, Stevens-Johnson syndrome-Toxic Epidermal Necrolysis overlap, erythroderma, maculopapular drug eruptions, and DRESS. Most of the patients (87.5%) had favorable outcome after hospitalization. There were 16 patients with drug hypersensitivity reaction hospitalized in Dr. Soetomo Hospital, Surabaya in 6 months period. Most of them were female and had type IV hypersensitivity reactions.
Effectivity of Erythropoietin Alpha Compared to Erythropoietin Beta in Patients with Chronic Kidney Disease-Anemia on Hemodialysis
Authors: Prasetya Anak Agung Ngurah Putra Riana , Suprapti Budi , Shanti Bayu Dharma
Published: January 2021

Anemia in patient with chronic kidney disease could cause a lot of complication. The first line therapy of this condition is by treating with erythropoiesis-stimulating agents (ESA) or called erythropoietin. The erythropoietin alpha and beta were two types of the human recombinant erythropoietin that are usually used in Indonesia. The aim of this study was to determine the effectivity of erythropoietin alpha compared to erythropoietin beta especially in haemoglobin and haematocrit level. This prospective observational study was conducted in March – September 2016. The inclusion criteria were CKD stage 5 patients with a minimum of 3 months of regular hemodialysis, Hb <10 g/dL with enough iron status ST > 20% and FS > 200ng/mL. The methology of this study had been approved by the Health Research Ethics Committee of the Bhayangkara H.S. Samsoeri Mertojoso Hospital, Surabaya. Patients received 2000 IU subcutaneous erythropoietin twice a week on both groups. Blood sample was withdrawn in pre-treatment and after 4 weeks of post erythropoietin therapy treatment for measurement of haemoglobin and haematocrit. Target for this erythropoietin therapy are increase of Hb 0.5 – 1.5 g/dL (not to exceed 12 g/dL) and increase of Hct level 2 – 4 % in 4 weeks. Based on the inclusion criteria, there were 20 patients in this study (10 patient each of both erythropoietin alpha either beta group) that consist of 7 women and 13 men. After the treatment, the mean of increased haemoglobin level for erythropoietin alpha group was 1.28 ± 0.80 g/dL (p=0.001) and erythropoietin beta was 0.37 ± 0.95 g/dL (p=0.254). The mean of increased haematocrit level for erytropoietin alpha group was 3.56 ± 3.46 % (p=0.010) and erythropoietin beta was 1.34 ± 2.71 % (p=0.152). In comparison of haemoglobin and haematocrit achievement in both groups showed that erythropoietin alpha gave better achievement in haemoglobin parameter (p=0.033), but there were no differences in both groups on haematocrit parameters (p=0.127).
Quality of Life of Diabetic Foot Ulcer Patients with Hyperbaric Oxygen Therapy
Authors: Kusnanto Kusnanto , Dismalyansa Dismalyansa , Pradanie Retnayu , Arifin Hidayat
Published: January 2021

DM with ulcer can result in a decrease in the quality of life of patients and need to reduce the intensity of pain and odor on the ulcer, preventing amputation and Hyperbaric Oxygen as an adjuvant therapy in accelerating wound healing. This study aims to explain the effect of HBO on the quality of life of patients with diabetic foot ulcers at RSAL Dr. Ramelan Surabaya. Methods: The research used quasi-experimental design with a non-equivalent control group design approach. The samples were 70 patients from population of all diabetes patients who suffered from diabetic foot ulcers at RSAL Dr. Ramelan. Data were collected by WHOQOL-BREF questionnaire. Analyzed byWilcoxon signed rank test and Mann Whitney U test. Result: Mann Whitney in the post test, the physical p-value domain (0.000), psychological domain (0.012), social domain (0.003), and environmental domain (0,001), where the intervention group has a better value than the control group. Wilcoxon signed rank test results on the physical domain (0,000), psychological (0,012), social (0,003), and environmental (0,001), meaning there were significant differences between pre post test in intervention group. Discussion: Diabetes mellitus patients with foot ulcers given hyperbaric oxygen showed improvement on wound condition, thus reducing pain and medical needs. This makes patients motivated, reduce anxiety, and improve interpersonal support and confidence. Therefore, it is necessary to socialize the effect of HBO on DM patients with foot ulcer, as a treatment option in improving the quality of life of DM patients with foot ulcers.
Correlation of Population and Environmental Behavior with Rat Density Rate in Plague Disease-Focus, Threatened and Safe Areas in Tutur District, Pasuruan Regency, 2016
Authors: Lestari Evi Noerista , Andajani Susilowati , Hadi Usman
Published: January 2021

Plague disease remains a public health problem in the world. According to the International Health Regulations (IHR), an outbreak is an infectious disease that has the potential to cause an outbreak. The purpose of this study was to analyze a significant relationship between human behavior and the environment with the density of the number of rats in the focus, threatened and outbreak-safe areas in Tutur Regency, Pasuruan Regency, in 2016. This was an observational analytic study with cross correlation sectional where the research variables are population behavior, environment, and the number of rat densities observed once at a time. The results showed that there was no significant relationship between the behavior (knowledge, attitude, and practice) of the population with the density of rats in the focus area of the Surorowo hamlet outbreak, in the endangered outbreaks of the Ngaro hamlet, and in the outbreak-safe area of the North Ngandong hamlet in Tutur District. Whereas, there is a significant relationship between environmental conditions and the amount of rat density in the focus area of the outbreak of the Surorowo hamlet (p: 0.047 or p <0.05), the threatened area of the Ngaro hamlet (p: 0.036 or p <0.05), and at outbreak-safe areas in Andong Utara hamlet (p: 0.047 or p <0.05). Conclusion: Environmental conditions are associated with the amount of rat density either in the outbreak, in focus, threatened, or in safe areas. That it is necessary to control environmental risk factors to reduce the amount of rat density.
Comparison of Antropometry and Physical Abilities between Trained and Untrained Individuals in Second Growth Phase
Authors: Akbar Idzam Kholid , Purwanto Bambang , Setijono Hari
Published: January 2021

The growth and development of the body goes through two phases of rapid growth. First phase (0-5 years) and second phase (10-17 years). This study aimed to compare anthropometry and physical abilities between trained and untrained individuals in the second rapid growth phase (adolescence). This research method used analytic observational with cross sectional design. The sample study used adolescents aged 14 years old, consisted of trained adolescent groups (n=25) and untrained adolescent groups (n=32), with categorized throught the International Physical Activity Questionnaires (IPAQ). Each group measured height, weight, chest circumference, vital lung capacity (VC), oxygen saturation (SpO2), heart rate resting, heart rate exercise, and VO2Max. The results of the different test between trained and untrained groups with a significance level of p<0.05 showed there were significant differences in body height (p=0.000), VC (p=0.000), SpO2 (p=0,001), heart rate rest (p=0.000), and VO2Max (p=0.000). There were no significant differences in body weight (p=0.053), chest circumference (p=0.226), and heart rate exercise (p=0.242). As a conclusion, anthropometry and physical abilities of trained individuals was greater than the untrained individuals in the second rapid growth phase (adolescence).
Effectivity of Erythropoietin-Alpha between Fixed- and Adjusted-Dose in Chronic Kidney Disease Patients With Anemia on Hemodialysis
Authors: Purwiningtyas Mida , Yulistiani Yulistiani , Suprapti Budi , Santi Bayu Dharma
Published: January 2021

Anemia is a common complication in chronic kidney disease (CKD) patient with hemodialysis. The cause of anemia is mainly due to erythropoetin deficiency because the kidneys as a erythropoetin producer are damaged. The most appropriate management of anemia in CKD with hemodialysis is the administration of Erythropoietin Stimulating Agent (ESA) or erythropoetin (Epo). The effectiveness of Epo therapy is influenced by the type of Epo used, the dose of Epo given, the route and frequency of Epo administration, as well as several conditions that affect it such as infection or inflammation, absolute and functional iron deficiency, and malnutrition. Therapeutic targets can be achieved if the dose given is in accordance with the needs of the patient, based on the patient's weight The purpose of this study was to determine the differences in the achievement of Epo-alpha fixed-dose administration compared with adjustment-dose in patients with CKD anemia with hemodialysis after administration of Epo-alpha for 4 weeks in outpatient poly hemodialysis units at Bhayangkara H.S Hospital. Samsoeri Mertojoso Surabaya. In this study, there were 20 patients who met the inclusion criteria (15 male and 5 female) divided into 2 groups, 10 patients in the fixed-dose group and 10 patients in the adjustment-dose group. In the fixed-dose group with a adequacy level of 132.25 ± 29.17, the average Hb change achievement was 0.68 ± 0.63 g / dL (p=0.008), whereas in the adjustment-dose group the achievement of the average Hb change the mean was 1.09 ± 0.82 g / dL (p=0.002). For the Hct parameter, the average Hct change in the fixed-dose group was 2.77 ± 2.23% (p=0.004), while in the adjustment-dose group the average Hct change achievement was 4.02 ± 2.63 g / dL (p=0.001). There was no difference in the achievement of the effectiveness of Epo on the two parameters Hb (p=0.224) and Hct (p=0.256) in the fixed-dose group compared with adjustment-dose.
Changes on Serum Troponin T Level before and after Taking Standard Therapy Medication in Heart Failure Patients
Authors: Indrawijaya Yen Yen Ari , Suharjono Suharjono , Aminuddin Muhammad , Retnowati Endang , Rahman Gilang Mauladi
Published: January 2021

Patients with advanced heart failure (NYHA FC III and IV heart failure) had positive cardiac troponin levels in previous cohort studies. In heart failure, cardiac troponin T (cTnT) is a biomarker that is sensitive to myocardial damage, especially myocardial necrosis. However, there is still little information regarding changes in cTnT levels during standard therapy. This prospective observational study is aimed at evaluating changes in cTnT levels before and after theadministration of standard therapy and evaluating symptom improvement before and after the administration of standard therapy in patients with severe heart failure. Measurement of cTnT levels and symptom improvement parameters before treatment was carried out on the first day of the inpatient and measurement after therapy was carried out on the last day of the inpatient. Sampling was done by consecutive sampling and found 30 patients in the inpatient room of the SMF Cardiovascular Disease, Dr. Soetomo Hospital, Surabaya during the months of May-July 2017. The results of the study obtained the average cTnT levels before therapy 33.48 + 31.88 pg/ml and the average cTnT levels after therapy 46.32 + 52.68 pg/ml. Based on the statistical difference test with the Wilcoxon sign-ranked test, there was no significant change in cTnT levels (p = 0.318). On the parameter of clinical symptom improvement, there was a significant decrease in pulse, respiratory rate, blood pressure, and mean arterial pressure before and after administration of therapy (p <0.05). There was no change in troponin T levels before and after the administration of therapy meant there was no worsening of myocardial necrosis.
Correlations Between Staging and Chemotheraphy Response with Testicular Carcinoma Non-Seminoma at Dr. Soetomo Hospital, Surabaya, Indonesia
Authors: Nugroho Ahmad , Renaldo Johan , Djatisoesanto Wahjoe
Published: January 2021

The purpose of this study to describe patientscharacteristics, correlation between stagingnon-seminomacancer and chemotherapyresponse. Data on age, location of tumor, staging, serum levels of the tumor marker post operative, adjuvant therapy, chemotherapy side effects, and response of patient to chemotherapy were gained from medical records inSoetomo Hospital Surabaya from January 2012 to December 2015, and analyzed with SPSS. Correlation between staging and chemotherapyresponse, correlation primary tumor staging (pT) and Metastasis (M), correlation regional lymph nodes staging (N) and metastasis (M), correlation serum tumor marker and chemotherapy response was proccessed by Spearman correlation test. There were no significant correlation between pT staging and M and no significant correlation between N and M staging. Based on tumor markers (S), mostly patients were S2. There were no significant correlation between the response to chemotherapy and serum tumor marker levels. In category of staging group, the mostare 14 patientsstage III. BEP was the most adjuvant Chemotherapy.Nausea and vomiting were The most complained during chemotherapy. Anemia were the most hematologic side effects of chemotherapy.There are no significant correlation between the staging of non-seminoma and the response to chemotherapy. Conclusion: Non seminoma mostly happened in young males. Non-seminoma responses to chemotherapy. Patients in early stage would give a good response to chemotherapy compared to those with advanced stage. After chemotherapy, evaluation should be done to the patients' complaints and complete blood count to detect side effects.