bluuebunny/crossref_metadata_2025 huggingface dataset:
Interfacing 2D Semiconductors with Functional Oxides: Fundamentals, Properties, and Applications
Authors: Yuan Zhiquan , Hou Jiwei , Liu Kai
Published: August 2017

Two-dimensional semiconductors, such as transition-metal dichalcogenides (TMDs) and black phosphorous (BP), have found various potential applications in electronic and opto-electronic devices. However, several problems including low carrier mobility and low photoluminescence efficiencies still limit the performance of these devices. Interfacing 2D semiconductors with functional oxides provides a way to address the problems by overcoming the intrinsic limitations of 2D semiconductors and offering them multiple functionalities with various mechanisms. In this review, we first focus on the physical effects of various types of functional oxides on 2D semiconductors, mostly on MoS2 and BP as they are the intensively studied 2D semiconductors. Insulating, semiconducting, conventional piezoelectric, strongly correlated, and magnetic oxides are discussed. Then we introduce the applications of these 2D semiconductors/functional oxides systems in field-effect devices, nonvolatile memory, and photosensing. Finally, we discuss the perspectives and challenges within this research field. Our review provides a comprehensive understanding of 2D semiconductors/functional oxide heterostructures, and could inspire novel ideas in interface engineering to improve the performance of 2D semiconductor devices.
Ultrathin g-C3N4 Nanosheet-Modified BiOCl Hierarchical Flower-Like Plate Heterostructure with Enhanced Photostability and Photocatalytic Performance
Authors: Jia Tiekun , Li Jili , Long Fei , Fu Fang , Zhao Junwei , Deng Zhao , Wang Xiaohui , Zhang Ying
Published: August 2017

A novel ultrathin g-C3N4 nanosheet-modified BiOCl hierarchical flower-like plate heterostructure (abbreviated as BC/CN) was constructed via a thermal polymerization of urea precursor followed with hydrolysis route. The as-prepared samples were well characterized by various analytical techniques. The morphological observation showed that hierarchical flower-like BiOCl nanoplates were discretely anchored on the surface of ultra-thin C3N4 nanosheets. The photocatalytic performance of the as-prepared photocatalysts was evaluated by degradation of methylene blue (MB) under visible-light irradiation. The results showed that BC/CN photocatalyst exhibited enhanced photostability and photocatalytic performance in the degradation process. On the basis of experimental results and the analysis of band energy structure, it could be inferred that the enhanced photocatalytic performance of BC/CN photocatalyst was intimately related with the hybridization of hierarchical flower-like BiOCl nanoplates with ultrathin g-C3N4 nanosheets, which provided good adsorptive capacity, extended light absorption, suppressed the recombination of photo-generated electron–hole pairs, and facilitated charge transfer efficiently.
The Evolution of Pediatric Disease—A Moving Target in Public Health
Authors: Brown Mark
Published: August 2017

There is a growing threat in the re-emergence of diseases that impact pediatric demographics. While major strides have been made in the field of childhood cancers, there are still more questions than answers. In addition, public resistance to recommended practices related to childhood vaccinations fueled by misinformation has allowed infectious diseases to resurface in developed nations. Meanwhile, climate change and other destabilizing factors are shifting vector populations and driving the emergence of new diseases. Herein we call upon the community of human health researchers to confront the evolving specter of pediatric disease.
Economics and Finance: q-Statistical Stylized Features Galore
Authors: Tsallis Constantino
Published: August 2017

The Boltzmann–Gibbs (BG) entropy and its associated statistical mechanics were generalized, three decades ago, on the basis of the nonadditive entropy S q ( q ∈ R ), which recovers the BG entropy in the q → 1 limit. The optimization of S q under appropriate simple constraints straightforwardly yields the so-called q-exponential and q-Gaussian distributions, respectively generalizing the exponential and Gaussian ones, recovered for q = 1 . These generalized functions ubiquitously emerge in complex systems, especially as economic and financial stylized features. These include price returns and volumes distributions, inter-occurrence times, characterization of wealth distributions and associated inequalities, among others. Here, we briefly review the basic concepts of this q-statistical generalization and focus on its rapidly growing applications in economics and finance.
Twisted Soft Photon Hair Implants on Black Holes
Authors: Tamburini Fabrizio , Laurentis Mariafelicia , Licata Ignazio , Thidé Bo
Published: August 2017

Background: The Hawking–Perry–Strominger (HPS) work states a new controversial idea about the black hole (BH) information paradox , where BHs maximally entropize and encode information in their event horizon area , with no “hair” thought to reveal information outside but angular momentum, mass, and electric charge only in a unique quantum gravity (QG) vacuum state. New conservation laws of gravitation and electromagnetism , appear to generate different QG vacua, preserving more information in soft photon/graviton hair implants. We find that BH photon hair implants can encode orbital angular momentum (OAM) and vorticity of the electromagnetic (EM) field. Methods: Numerical simulations are used to plot an EM field with OAM emitted by a set of dipolar currents together with the soft photon field they induce. The analytical results confirm that the soft photon hair implant carries OAM and vorticity. Results: a set of charges and currents generating real EM fields with precise values of OAM induce a “curly”, twisted, soft-hair implant on the BH with vorticity and OAM increased by one unit with respect to the initial real field. Conclusions: Soft photon implants can be spatially shaped ad hoc, encoding structured and densely organized information on the event horizon.
One-Step Self-Assembly Synthesis α-Fe2O3 with Carbon-Coated Nanoparticles for Stabilized and Enhanced Supercapacitors Electrode
Authors: Yan Yizhi , Tang Haolin , Wu Fan , Wang Rui , Pan Mu
Published: August 2017

A cocoon-like α-Fe2O3 nanocomposite with a novel carbon-coated structure was synthesized via a simple one-step hydrothermal self-assembly method and employed as supercapacitor electrode material. It was observed from electrochemical measurements that the obtained α-Fe2O3@C electrode showed a good specific capacitance (406.9 Fg−1 at 0.5 Ag−1) and excellent cycling stability, with 90.7% specific capacitance retained after 2000 cycles at high current density of 10 Ag−1. These impressive results, presented here, demonstrated that α-Fe2O3@C could be a promising alternative material for application in high energy density storage.
Soundwalking: Deep Listening and Spatio-Temporal Montage
Authors: Brown Andrew
Published: August 2017

The bicentenary of the 1817 Pentrich Revolution provided an opportunity for the composition of a series of soundwalks that, in turn, offer themselves up as a case study in an exposition of spatial bricolage, from the perspective of an interdisciplinary artist working with the medium of locative sound. Informed by Doreen Massey’s definition of space as ‘a simultaneity of stories so far’, the author’s approach involves extracting sounds from the contemporary soundscape and re-introducing them in the form of multi-layered compositions. This article conducts an analysis of the author’s soundwalking practice according to Max van Manen’s formulation of four essential categories of experience through which to consider our ‘lived world’: spatiality, temporality, corporeality, and relationality. Drawing upon theorists whose concerns include cinematic, mobile and environmental sound, such as Chion, Chambers and Schafer, the author proposes the soundwalk as as an expanded form of cinema, with the flexibility to provoke states of immersion was well as critical detachment. A case is made for the application of the medium within the artistic investigation into ecological and socio-political issues alongside aesthetic concerns.
Spatial Variability of Geriatric Depression Risk in a High-Density City: A Data-Driven Socio-Environmental Vulnerability Mapping Approach
Authors: Ho Hung , Lau Kevin , Yu Ruby , Wang Dan , Woo Jean , Kwok Timothy , Ng Edward
Published: August 2017

Previous studies found a relationship between geriatric depression and social deprivation. However, most studies did not include environmental factors in the statistical models, introducing a bias to estimate geriatric depression risk because the urban environment was found to have significant associations with mental health. We developed a cross-sectional study with a binomial logistic regression to examine the geriatric depression risk of a high-density city based on five social vulnerability factors and four environmental measures. We constructed a socio-environmental vulnerability index by including the significant variables to map the geriatric depression risk in Hong Kong, a high-density city characterized by compact urban environment and high-rise buildings. Crude and adjusted odds ratios (ORs) of the variables were significantly different, indicating that both social and environmental variables should be included as confounding factors. For the comprehensive model controlled by all confounding factors, older adults who were of lower education had the highest geriatric depression risks (OR: 1.60 (1.21, 2.12)). Higher percentage of residential area and greater variation in building height within the neighborhood also contributed to geriatric depression risk in Hong Kong, while average building height had negative association with geriatric depression risk. In addition, the socio-environmental vulnerability index showed that higher scores were associated with higher geriatric depression risk at neighborhood scale. The results of mapping and cross-section model suggested that geriatric depression risk was associated with a compact living environment with low socio-economic conditions in historical urban areas in Hong Kong. In conclusion, our study found a significant difference in geriatric depression risk between unadjusted and adjusted models, suggesting the importance of including environmental factors in estimating geriatric depression risk. We also developed a framework to map geriatric depression risk across a city, which can be used for identifying neighborhoods with higher risk for public health surveillance and sustainable urban planning.
Patient-Derived Orthotopic Xenograft (PDOX) Models of Melanoma
Authors: Hoffman Robert
Published: August 2017

Metastatic melanoma is a recalcitrant tumor. Although “targeted” and immune therapies have been highly touted, only relatively few patients have had durable responses. To overcome this problem, our laboratory has established the melanoma patient-derived orthotopic xenograft (PDOX) model with the use of surgical orthotopic implantation (SOI). Promising results have been obtained with regard to identifying effective approved agents and experimental therapeutics, as well as combinations of the two using the melanoma PDOX model.
Inflammatory Diseases and Growth: Effects on the GH–IGF Axis and on Growth Plate
Authors: Cirillo Francesca , Lazzeroni Pietro , Sartori Chiara , Street Maria
Published: August 2017

This review briefly describes the most common chronic inflammatory diseases in childhood, such as cystic fibrosis (CF), inflammatory bowel diseases (IBDs), juvenile idiopathic arthritis (JIA), and intrauterine growth restriction (IUGR) that can be considered, as such, for the changes reported in the placenta and cord blood of these subjects. Changes in growth hormone (GH) secretion, GH resistance, and changes in the insulin-like growth factor (IGF) system are described mainly in relationship with the increase in nuclear factor-κB (NF-κB) and pro-inflammatory cytokines. Changes in the growth plate are also reported as well as a potential role for microRNAs (miRNAs) and thus epigenetic changes in chronic inflammation. Many mechanisms leading to growth failure are currently known; however, it is clear that further research in the field is still warranted.
Genitalic Differentiations in Neoleucinodes elegantalis (Gueneé) (Lepidoptera: Crambidae) Associated with Solanaceae Crops in Ecuador
Authors: Noboa Michelle , Viera William , Díaz Ana , Vásquez Wilson , Ron Lenin
Published: August 2017

Neoleucinodes elegantalis (Guenée) is an oligophagous species of plants in the Solanaceae family that has a broad geographical distribution in the tropical zones of South America. It is the most important insect pest of naranjilla (Solanum quitoense Lamarck), a crop grown in threatened areas of the tropical old-growth forest in Ecuador. In this study, two host-specific populations of N. elegantalis were collected from infested fruit of naranjilla and tree tomato (Solanum betaceum Cavanilles) in different locations. Sexually virgin adult insects (93 females and 103 males) were dissected to extract their genitalia to measure 12 morphological variables in females and six in males, resulting in six and four informative variables respectively. Using univariate and multivariate analysis of variance, it was found that the Solanaceous host was the main factor differentiating the area measurements of the seventh abdominal segment and ostium bursae in female genitalia, and cornuti length in male genitalia. Principal components generated with these measurements were employed in a logistic regression model for the classification of the Solanaceous host. Female genitalia of individuals from S. betaceum showed significantly larger ostium bursae relative to female genitalia from S. quitoense. For males, individuals collected from S. betaceum showed longer cornuti length than samples collected from S. quitoense. The results suggest genotypic differentiation according to the Solanaceous host or phenotypic plasticity in N. elegantalis. Further molecular and bio-geographical studies are needed to properly differentiate N. elegantalis populations that would help in the control of this pest.
Efficacy of Chlorantraniliprole in Controlling Structural Infestations of the Eastern Subterranean Termite in the USA
Authors: Jones Susan , Vargo Edward , Keefer T. , Labadie Paul , Scherer Clay , Gallagher Nicola , Gold Roger
Published: August 2017

Subterranean termites are the most economically important structural pests in the USA, and the eastern subterranean termite, Reticulitermes flavipes (Kollar) (Dictyoptera: Rhinotermitidae) is the most widely distributed species. Soil treatment with a liquid termiticide is a widely used method for controlling subterranean termites in structures. We assessed the efficacy of a nonrepellent termiticide, Altriset® (active ingredient: chlorantraniliprole), in controlling structural infestations of R. flavipes in Texas, North Carolina, and Ohio and determined the post-treatment fate of termite colonies in and around the structures. In all three states, microsatellite markers indicated that only one R. flavipes colony was infesting each structure. A single chlorantraniliprole treatment provided effective structural protection as there was no further evidence of termite activity in and on the majority of structures from approximately 1 month to 2 years post-treatment when the study concluded. Additionally, the treatment appeared to either severely reduce the infesting colony’s footprint at monitors in the landscape or eliminate colony members from these monitors. A supplemental spot-treatment was conducted at one house each in Texas and North Carolina at 5 and 6 months post-treatment, respectively; no termites were observed thereafter in these structures and associated landscaping. The number of colonies found exclusively in the landscape (not attacking the structure) varied among the states, with the largest number of colonies in Texas (0–4) and North Carolina (0–5) as compared to 0–1 in Ohio, the most northern state.
Insecticides for Suppression of Nylanderia fulva
Authors: Calibeo Dawn , Oi Faith , Oi David , Mannion Catharine
Published: August 2017

Nylanderia fulva (Mayr) is an invasive ant that is a serious pest in the southern United States. Pest control operators and homeowners are challenged to manage pest populations below acceptable thresholds. Contact and bait insecticides are key components of an Integrated Pest Management (IPM) strategy, however, little is known about their efficacy. In repellency and efficacy bioassays, N. fulva were not completely repelled by any insecticide tested, although fewer ants crossed a surface treated with Temprid®. Few insecticides provided rapid control. Termidor® and Temprid® were the best performing with mean mortality of 100% in 13.4 and 19.0 days, respectively. In no-choice bait acceptance studies, it was shown that N. fulva generally had greater acceptance of carbohydrate-based ant baits (Advion®, InTiceTM (gel), and InTiceTM (granular)). However, mortality was low for the InTiceTM baits in a 7-day bioassay. Maxforce® Ant Killer Bait Gel and Advance® 375A in the spring and Maxforce® Complete in the summer and fall required the fewest days to reach 100% mortality. Bait active ingredients that resulted in the highest mortality were hydramethylnon and fipronil. These data on the efficacy of commercially available contact and bait insecticides provide valuable information to manage this invasive pest.
Analysing Renewable Energy Source Impacts on Power System National Network Code
Authors: Balaban Georgiana , Lazaroiu George , Dumbrava Virgil , Sima Catalina
Published: August 2017

This paper analyses the impact on renewable energy sources integrated into the Romanian power system on the electrical network operation considering the reduction of electricity consumption with respect to the 1990s. This decrease has led to increased difficulties in integrating the renewable energy sources into the power system (network reinforcements), as well as issues concerning the balance of production/consumption. Following the excess of certain proportions of the energy mix, intermittent renewable energy sources require the expansion of networks, storage, back-up capacities and efforts for a flexible consumption, in the absence of which renewable energy sources cannot be used or the grid can be overloaded. To highlight the difficulty of connecting some significant capacities installed in wind power plants and photovoltaic installation, the paper presents a case study for Dobrogea area that has the most installed capacity from renewable energy sources in operation.
Evaluation of Isokinetic Single-Leg Cycling as a Rehabilitation Exercise Following Anterior Cruciate Ligament Reconstruction Surgery
Authors: Hutchison Randolph , Myers Jessica , Hayden Nicholas , Shearer Lee , Bruneau Kaitlin , DesJardins John
Published: August 2017

The anterior cruciate ligament (ACL) is one of the most commonly injured ligaments, with over 250,000 injuries per year in the United States. Previous studies have found that ACL-deficient individuals avoid use of the quadriceps in the injured limb as a means of limiting anterior movement of the tibia in the absence of a functioning ACL. From these results, a study was designed to investigate the effectiveness of isokinetic single-leg cycling in increasing quadriceps muscle recruitment and activation. Ten control and seven ACL-reconstructed subjects completed a series of 15 s cycling trials in isokinetic mode at 75 rpm, while kinematic, kinetic, and electromyographic data of the lower limbs were collected, with the trials including both double-leg and single-leg cycling. It was hypothesized that there would be an increase in quadriceps muscle activity, peak knee extensor moment, and knee joint power in single-leg cycling when compared to double-leg cycling. The results of the study suggest that single-leg cycling may be an effective exercise in increasing the strength of the quadriceps following anterior cruciate ligament reconstruction surgery. Although no significant changes occurred, the results indicate that, given a specific limb power, more muscle force will be generated from the quadriceps muscle group in single-leg cycling than double-leg cycling.
A Review of Recent Advances towards the Development of (Quantitative) Structure-Activity Relationships for Metallic Nanomaterials
Authors: Chen Guangchao , Vijver Martina , Xiao Yinlong , Peijnenburg Willie
Published: August 2017

Gathering required information in a fast and inexpensive way is essential for assessing the risks of engineered nanomaterials (ENMs). The extension of conventional (quantitative) structure-activity relationships ((Q)SARs) approach to nanotoxicology, i.e., nano-(Q)SARs, is a possible solution. The preliminary attempts of correlating ENMs’ characteristics to the biological effects elicited by ENMs highlighted the potential applicability of (Q)SARs in the nanotoxicity field. This review discusses the current knowledge on the development of nano-(Q)SARs for metallic ENMs, on the aspects of data sources, reported nano-(Q)SARs, and mechanistic interpretation. An outlook is given on the further development of this frontier. As concluded, the used experimental data mainly concern the uptake of ENMs by different cell lines and the toxicity of ENMs to cells lines and Escherichia coli. The widely applied techniques of deriving models are linear and non-linear regressions, support vector machine, artificial neural network, k-nearest neighbors, etc. Concluded from the descriptors, surface properties of ENMs are seen as vital for the cellular uptake of ENMs; the capability of releasing ions and surface redox properties of ENMs are of importance for evaluating nanotoxicity. This review aims to present key advances in relevant nano-modeling studies and stimulate future research efforts in this quickly developing field of research.
Force Transmission Modes of Non-Cohesive and Cohesive Materials at the Critical State
Authors: Wang Ji-Peng
Published: August 2017

This paper investigates the force transmission modes, mainly described by probability density distributions, in non-cohesive dry and cohesive wet granular materials by discrete element modeling. The critical state force transmission patterns are focused on with the contact model effect being analyzed. By shearing relatively dense and loose dry specimens to the critical state in the conventional triaxial loading path, it is observed that there is a unique critical state force transmission mode. There is a universe critical state force distribution pattern for both the normal contact forces and tangential contact forces. Furthermore, it is found that using either the linear Hooke or the non-linear Hertz model does not affect the universe force transmission mode, and it is only related to the grain size distribution. Wet granular materials are also simulated by incorporating a water bridge model. Dense and loose wet granular materials are tested, and the critical state behavior for the wet material is also observed. The critical state strength and void ratio of wet granular materials are higher than those of a non-cohesive material. The critical state inter-particle distribution is altered from that of a non-cohesive material with higher probability in relatively weak forces. Grains in non-cohesive materials are under compressive stresses, and their principal directions are mainly in the axial loading direction. However, for cohesive wet granular materials, some particles are in tension, and the tensile stresses are in the horizontal direction on which the confinement is applied. The additional confinement by the tensile stress explains the macro strength and dilatancy increase in wet samples.
In situ Observation of Phase Transformation in MnAl(C) Magnetic Materials
Authors: Si Ping-Zhan , Qian Hui-Dong , Choi Chul-Jin , Park Jihoon , Han Sangho , Ge Hong-Liang , Shinde Kiran
Published: August 2017

The phase transformation in two modes, including both displacive and massive growth of τ-phase from ε-MnAl(C), was observed by in situ transmission electron microscopy. The exact temperature range for different phase transformation modes was determined by magnetic measurements. The displacive growth of ε→τ in Mn54Al46 (or Mn54Al46C2.44) occurs at temperatures below 650 K (or 766 K), above which both modes coexist. One-third or less of the ε-phase can be transformed into τ-phase via displacive mode while the remaining two-thirds or more via massive mode. In bulk τ-phase, most τ-nanocrystals formed via displacive mode are distributed in the matrix of large τ-grains that formed via massive mode. The typical massive growth rate of the τ-phase is 8–60 nm/s, while the displacive growth rate is low. A more complete understanding of the ε→τ phase transformations in the MnAl-based magnets was provided in this work, based on which the annealing process for ε→τ was optimized and thus high purity τ-phase with high saturation magnetization was obtained.
New Antifeedant Grayanane Diterpenoids from the Flowers of Pieris formosa
Authors: Li Chun-Huan , Luo Shi-Hong , Li Sheng-Hong , Gao Jin-Ming
Published: August 2017

Three new grayanane diterpenoids, pierisoids C‒E (1–3), as well as 10 known ones (4–13), were evaluated from the flowers of Pieris formosa, which is used as an insecticide in rural areas of China. Their structures were elucidated on the basis of extensive 1D and 2D NMR spectroscopic data analyses. Significant antifeedant activity of 1, 3 and 10 against the beet armyworm (Spodoptera exigua) was found, indicating that these diterpenoids might also be involved in the plant defense against insect herbivores.
Novel Selective Estrogen Receptor Ligand Conjugates Incorporating Endoxifen-Combretastatin and Cyclofenil-Combretastatin Hybrid Scaffolds: Synthesis and Biochemical Evaluation
Authors: Kelly Patrick , Keely Niall , Bright Sandra , Yassin Bassem , Ana Gloria , Fayne Darren , Zisterer Daniela , Meegan Mary
Published: August 2017

Nuclear receptors such as the estrogen receptors (ERα and ERβ) modulate the effects of the estrogen hormones and are important targets for design of innovative chemotherapeutic agents for diseases such as breast cancer and osteoporosis. Conjugate and bifunctional compounds which incorporate an ER ligand offer a useful method of delivering cytotoxic drugs to tissue sites such as breast cancers which express ERs. A series of novel conjugate molecules incorporating both the ER ligands endoxifen and cyclofenil-endoxifen hybrids covalently linked to the antimitotic and tubulin targeting agent combretastatin A-4 were synthesised and evaluated as ER ligands. A number of these compounds demonstrated pro-apoptotic effects, with potent antiproliferative activity in ER-positive MCF-7 breast cancer cell lines and low cytotoxicity. These conjugates displayed binding affinity towards ERα and ERβ isoforms at nanomolar concentrations e.g., the cyclofenil-amide compound 13e is a promising lead compound of a clinically relevant ER conjugate with IC50 in MCF-7 cells of 187 nM, and binding affinity to ERα (IC50 = 19 nM) and ERβ (IC50 = 229 nM) while the endoxifen conjugate 16b demonstrates antiproliferative activity in MCF-7 cells (IC50 = 5.7 nM) and binding affinity to ERα (IC50 = 15 nM) and ERβ (IC50 = 115 nM). The ER binding effects are rationalised in a molecular modelling study in which the disruption of the ER helix-12 in the presence of compounds 11e, 13e and 16b is presented These conjugate compounds have potential application for further development as antineoplastic agents in the treatment of ER positive breast cancers.
Evaluation of Rhamnetin as an Inhibitor of the Pharmacological Effect of Secretory Phospholipase A2
Authors: Novo Belchor Mariana , Hessel Gaeta Henrique , Fabri Bittencourt Rodrigues Caroline , Ramos da Cruz Costa Caroline , De Oliveira Toyama Daniela , Domingues Passero Luiz , Dalastra Laurenti Marcia , Hikari Toyama Marcos
Published: August 2017

Rhamnetin (Rhm), 3-O-methylquercetin (3MQ), and Rhamnazin (Rhz) are methylated derivatives of quercetin commonly found in fruits and vegetables that possess antioxidant and anti-inflammatory properties. Phospholipase A2 (PLA2) displays several important roles during acute inflammation; therefore, this study aimed at investigating new compounds able to inhibit this enzyme, besides evaluating creatine kinase (CK) levels and citotoxicity. Methylated quercetins were compared with quercetin (Q) and were incubated with secretory PLA2 (sPLA2) from Bothrops jararacussu to determine their inhibitory activity. Cytotoxic studies were performed by using the J774 cell lineage incubated with quercertins. In vivo tests were performed with Swiss female mice to evaluate decreasing paw edema potential and compounds’ CK levels. Structural modifications on sPLA2 were made with circular dichroism (CD). Despite Q and Rhz showing greater enzymatic inhibitory potential, high CK was observed. Rhm exhibited sPLA2 inhibitory potential, no toxicity and, remarkably, it decreased CK levels. The presence of 3OH on the C-ring of Rhm may contribute to both its anti-inflammatory and enzymatic inhibition of sPLA2, and the methylation of ring A may provide the increase in cell viability and low CK level induced by sPLA2. These results showed that Rhm can be a candidate as a natural compound for the development of new anti-inflammatory drugs.
Comparison of Chemical Profiles, Anti-Inflammatory Activity, and UPLC-Q-TOF/MS-Based Metabolomics in Endotoxic Fever Rats between Synthetic Borneol and Natural Borneol
Authors: Zou Liang , Zhang Yan , Li Wei , Zhang Jinming , Wang Dan , Fu Jia , Wang Ping
Published: August 2017

Natural borneol (NB, called “Bingpian”) is an important traditional Chinese medicine to restore consciousness, remove heat and relieve pain, all of which are inflammation-related diseases. Recently, due to the limited source of NB, synthetic borneol (SB) is widely used as a substitute for NB in clinics. However, little is known about the effects of SB instead of NB. Herein, the aim of the present study was to compare NB and SB on chemical profiles by gas chromatography-mass spectrometer (GC-MS) analysis, anti-inflammatory activity in lipopolysaccharide (LPS)-induced RAW 264.7 macrophages, and ultra-performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF/MS) metabolomic approaches in endotoxic fever induced in rats. Results showed that, in total, 13 volatile components could be identified in NB and SB by GC-MS analysis, in which a significant difference between them still existed. The main constituents in SB were iso-borneol and borneol, while borneol contributes to 98.96% of the amount in NB. Additionally, both NB and SB exhibited remarkable anti-inflammatory effects to reduce the level of inflammatory factors including NO, TNF-α and IL-6 in LPS-induced RAW 264.7 macrophages, and lower the high body temperature in rats with endotoxic fever induced by LPS. Moreover, it seems that NB exhibited higher efficacy than SB. The unequal bioactive efficiency between NB and SB was also indicated by means of non-targeting metabolomics. Based on UPLC-Q-TOF/MS technology, 12 biomarkers in the serum of fever rats were identified. Pathway analysis revealed that the anti-fever effect of NB and SB was related to regulating the abnormal glycerophospholipid, linoleic acid and alpha-linoleic acid metabolism pathways in the fever model. Results indicated that there was still a great difference between NB and SB involving chemical constituents, anti-inflammation activity and the ability to regulate the abnormal metabolism pathways of the fever model. Certainly, further studies are warranted to better understand the replacement rationale in medicinal application.
Gadolinium-Doped Gallic Acid-Zinc/Aluminium-Layered Double Hydroxide/Gold Theranostic Nanoparticles for a Bimodal Magnetic Resonance Imaging and Drug Delivery System
Authors: Sani Usman Muhammad , Hussein Mohd , Fakurazi Sharida , Masarudin Mas , Ahmad Saad Fathinul
Published: August 2017

We have developed gadolinium-based theranostic nanoparticles for co-delivery of drug and magnetic resonance imaging (MRI) contrast agent using Zn/Al-layered double hydroxide as the nanocarrier platform, a naturally occurring phenolic compound, gallic acid (GA) as therapeutic agent, and Gd(NO3)3 as diagnostic agent. Gold nanoparticles (AuNPs) were grown on the system to support the contrast for MRI imaging. The nanoparticles were characterized using techniques such as Hi-TEM, XRD, ICP-ES. Kinetic release study of the GA from the nanoparticles showed about 70% of GA was released over a period of 72 h. The in vitro cell viability test for the nanoparticles showed relatively low toxicity to human cell lines (3T3) and improved toxicity on cancerous cell lines (HepG2). A preliminary contrast property test of the nanoparticles, tested on a 3 Tesla MRI machine at various concentrations of GAGZAu and water (as a reference) indicates that the nanoparticles have a promising dual diagnostic and therapeutic features to further develop a better future for clinical remedy for cancer treatment.
Effect of Processing Intensity on Immunologically Active Bovine Milk Serum Proteins
Authors: Brick Tabea , Ege Markus , Boeren Sjef , Böck Andreas , Von Mutius Erika , Vervoort Jacques , Hettinga Kasper
Published: August 2017

Consumption of raw cow’s milk instead of industrially processed milk has been reported to protect children from developing asthma, allergies, and respiratory infections. Several heat-sensitive milk serum proteins have been implied in this effect though unbiased assessment of milk proteins in general is missing. The aim of this study was to compare the native milk serum proteome between raw cow’s milk and various industrially applied processing methods, i.e., homogenization, fat separation, pasteurization, ultra-heat treatment (UHT), treatment for extended shelf-life (ESL), and conventional boiling. Each processing method was applied to the same three pools of raw milk. Levels of detectable proteins were quantified by liquid chromatography/tandem mass spectrometry following filter aided sample preparation. In total, 364 milk serum proteins were identified. The 140 proteins detectable in 66% of all samples were entered in a hierarchical cluster analysis. The resulting proteomics pattern separated mainly as high (boiling, UHT, ESL) versus no/low heat treatment (raw, skimmed, pasteurized). Comparing these two groups revealed 23 individual proteins significantly reduced by heating, e.g., lactoferrin (log2-fold change = −0.37, p = 0.004), lactoperoxidase (log2-fold change = −0.33, p = 0.001), and lactadherin (log2-fold change = −0.22, p = 0.020). The abundance of these heat sensitive proteins found in higher quantity in native cow’s milk compared to heat treated milk, renders them potential candidates for protection from asthma, allergies, and respiratory infections.
Probiotic Supplementation in Preterm: Feeding Intolerance and Hospital Cost
Authors: Indrio Flavia , Riezzo Giuseppe , Tafuri Silvio , Ficarella Maria , Carlucci Barbara , Bisceglia Massimo , Polimeno Lorenzo , Francavilla Ruggiero
Published: August 2017

We hypothesized that giving the probiotic strain Lactobacillus reuteri (L. reuteri) DSM 17938 to preterm, formula-fed infants would prevent an early traumatic intestinal inflammatory insult modulating intestinal cytokine profile and reducing the onset of feeding intolerance. Newborn were randomly allocated during the first 48 h of life to receive either daily probiotic (108 colony forming units (CFUs) of L. reuteri DSM 17938) or placebo for one month. All the newborns underwent to gastric ultrasound for the measurement of gastric emptying time. Fecal samples were collected for the evaluation of fecal cytokines. Clinical data on feeding intolerance and weight gain were collected. The costs of hospital stays were calculated. The results showed that the newborns receiving L. reuteri DSM 17938 had a significant decrease in the number of days needed to reach full enteral feeding (p < 0.01), days of hospital stay (p < 0.01), and days of antibiotic treatment (p < 0.01). Statistically significant differences were observed in pattern of fecal cytokine profiles. The anti-inflammatory cytokine interleukin (IL)-10, was increased in newborns receiving L. reuteri DSM 17938. Pro-inflammatory cytokines: IL-17, IL-8, and tumor necrosis factor (TNF)-alpha levels were increased in newborns given placebo. Differences in the gastric emptying and fasting antral area (FAA) were also observed. Our study demonstrates an effective role for L. reuteri DSM 17938 supplementation in preventing feeding intolerance and improving gut motor and immune function development in bottle-fed stable preterm newborns. Another benefit from the use of probiotics is the reducing cost for the Health Care service.
Microscopic Examination of Polymeric Monoguanidine, Hydrochloride-Induced Cell Membrane Damage in Multidrug-Resistant Pseudomonas aeruginosa
Authors: Cao Xun , Meng Lu , Zhang Niya , Zhou Zhongxin
Published: August 2017

Advances in antimicrobial activities of molecule-containing, multiple guanidinium groups against antibiotics-resistant bacteria should be noted. The synthesized polyoctamethylene monoguanidine hydrochloride (POGH), carrying cationic amphiphilic moieties, display excellent activity against multidrug-resistant Pseudomonas aeruginosa (MDR-PA) and other antibiotics-resistant bacteria. The membrane damage effects of POGH on MDR-PA were clarified using beta-lactamase activity assay, confocal fluorescence microscopy, scanning electron microscopy, and transmission electron microscopy. The results showed that POGH disrupted both the outer and inner membranes and the intracellular structure of MDR-PA to different extents depending on the dose. All concentrations of POGH within 3–23 μg/mL increased the outer membrane permeability, which facilitated the release of beta-lactamase across the inner membrane. A median dose (10 μg/mL) of POGH led to the separation of the inner and outer membrane, an increase in the membrane gap, and outer membrane structure damage with still maintained overall cytoskeletal structures. The application of a 30 μg/mL dose of POGH led to the collapse of the outer membrane, cellular wrinkling, and shrinkage, and the formation of local membrane holes. The disruption of the outer and inner membranes and the formation of the local membrane holes by a relative high dose were probably the main bactericidal mechanism of POGH. The microscopic evidence explained the strong outer-membrane permeation ability of guanidine-based antimicrobial polymers, which could be considered for the molecular design of novel guanidine-based polymers, as well as the damaged membrane structure and intracellular structure of MDR-PA.
Tunable Electrical Conductivity of Carbon-Black-Filled Ternary Polymer Blends by Constructing a Hierarchical Structure
Authors: Zhang Qiyan , Zhang Bo-Yuan , Guo Zhao-Xia , Yu Jian
Published: August 2017

A type of hierarchical structured composite composed of a minor thermoplastic polyurethane (TPU) phase spreading at the interface of two major phases polyoxymethylene/polyamide copolymer (POM/COPA) and carbon black (CB) particles selectively localized at the TPU/COPA interface of the tri-continuous blends was fabricated by melt compounding. The hierarchical structure was designed according to predictions and verified by a combination of electron microscopy and solvent extraction technique. The hierarchical structured composites show the dramatically decreased percolation threshold, a reduction of 60% compared to those without TPU where CB is selectively distributed in the COPA phase. The effects of CB contents and TPU on the phase morphology of POM/COPA were investigated, showing the occurrence of the POM/COPA phase inversion from a sea-island to a co-continuous structure beyond the percolation threshold of CB in the presence of TPU. The mechanism for the formation of conductive network is construction of CB network at the TPU/COPA interface of tri-continuous POM/COPA/TPU blends and double percolation effect.
Irrigation-Induced Environmental Changes around the Aral Sea: An Integrated View from Multiple Satellite Observations
Authors: Jin Qinjian , Wei Jiangfeng , Yang Zong-Liang , Lin Peirong
Published: August 2017

The Aral Sea basin (ASB) is one of the most environmentally vulnerable regions to climate change and human activities. During the past 60 years, irrigation has greatly changed the water distribution and caused severe environmental issues in the ASB. Using remote sensing data, this study investigated the environmental changes induced by irrigation activities in this region. The results show that, in the past decade, land water storage has significantly increased in the irrigated upstream regions (13 km3 year−1) but decreased in the downstream regions (−27 km3 year−1) of the Amu Darya River basin, causing a water storage decrease in the whole basin (−20 km3 year−1). As a result, the water surface area of the Aral Sea has decreased from 32,000 in 2000 to 10,000 km2 in 2015. The shrinking Aral Sea exposed a large portion of the lake bottom to the air, increasing (decreasing) the daytime (nighttime) temperatures by about 1 °C year−1 (0.5 °C year−1). Moreover, there were other potential environmental changes, including drier soil, less vegetation, decreasing cloud and precipitation, and more severe and frequent dust storms. Possible biases in the remote sensing data due to the neglect of the shrinking water surface area of the Aral Sea were identified. These findings highlight the severe environmental threats caused by irrigation in Central Asia and call attention to sustainable water use in such dryland regions.
A Small UAV Based Multi-Temporal Image Registration for Dynamic Agricultural Terrace Monitoring
Authors: Wei Ziquan , Han Yifeng , Li Mengya , Yang Kun , Yang Yang , Luo Yi , Ong Sim-Heng
Published: August 2017

Terraces are the major land-use type of agriculture and support the main agricultural production in southeast and southwest China. However, due to smallholder farming, complex terrains, natural disasters and illegal land occupations, a light-weight and low cost dynamic monitoring of agricultural terraces has become a serious concern for smallholder production systems in the above area. In this work, we propose a small unmanned aerial vehicle (UAV) based multi-temporal image registration method that plays an important role in transforming multi-temporal images into one coordinate system and determines the effectiveness of the subsequent change detection for dynamic agricultural terrace monitoring. The proposed method consists of four steps: (i) guided image filtering based agricultural terrace image preprocessing, (ii) texture and geometric structure features extraction and combination, (iii) multi-feature guided point set registration, and (iv) feature points based image registration. We evaluated the performance of the proposed method by 20 pairs of aerial images captured from Longji and Yunhe terraces, China using a small UAV (the DJI Phantom 4 Pro), and also compared against four state-of-the-art methods where our method shows the best alignments in most cases.
Diurnal Cycle in Atmospheric Water over Switzerland
Authors: Hocke Klemens , Navas-Guzmán Francisco , Moreira Lorena , Bernet Leonie , Mätzler Christian
Published: August 2017

The TROpospheric WAter RAdiometer (TROWARA) is a ground-based microwave radiometer with an additional infrared channel observing atmospheric water parameters in Bern, Switzerland. TROWARA measures with nearly all-weather capability during day- and nighttime with a high temporal resolution (about 10 s). Using the almost complete data set from 2004 to 2016, we derive and discuss the diurnal cycles in cloud fraction (CF), integrated liquid water (ILW) and integrated water vapour (IWV) for different seasons and the annual mean. The amplitude of the mean diurnal cycle in IWV is 0.41 kg/m 2 . The sub-daily minimum of IWV is at 10:00 LT while the maximum of IWV occurs at 19:00 LT. The relative amplitudes of the diurnal cycle in ILW are up to 25% in October, November and January, which is possibly related to a breaking up of the cloud layer at 10:00 LT. The minimum of ILW occurs at 12:00 LT, which is due to cloud solar absorption. In case of cloud fraction of liquid water clouds, maximal values of +10% are reached at 07:00 LT and then a decrease starts towards the minimum of −10%, which is reached at 16:00 LT in autumn. This breakup of cloud layers in the late morning and early afternoon hours seems to be typical for the weather in Bern in autumn. Finally, the diurnal cycle in rain fraction is analysed, which shows an increase of a few percent in the late afternoon hours during summer.
A Novel Organic Electrochemical Transistor-Based Platform for Monitoring the Senescent Green Vegetative Phase of Haematococcus pluvialis Cells
Authors: Wei Weiwei , Xiao Kang , Tao Ming , Nie Lifu , Liu Dan , Ke Shanming , Zeng Xierong , Hu Zhangli , Lin Peng , Zhang Yu
Published: August 2017

The freshwater unicellular microalga Haematococcus pluvialis (H. pluvialis) has gained increasing attention because of its high-value metabolite astaxanthin, a super anti-oxidant. For the maximum astaxanthin production, a key problem is how to determine the senescent green vegetative phase of H. pluvialis cells to apply the astaxanthin production inducers. The conventional methods are time-consuming and laborious. In this study, a novel platform based on organic electrochemical transistor (OECT) was produced. A significant channel current change of OECTs caused by settled H. pluvialis cells on the poly(3,4-ethylenedioxythiophene): polystyrene sulfonate (PEDOT: PSS) film was recorded commencing from 75 min and a stationary stage was achieved at 120 min after the combined treatment of blue light irradiation and sodium bicarbonate solution additives, which indicate the onset and maturation of the senescent green vegetative phase, respectively. Therefore, the appropriate time point (120 min after sample loading) to apply astaxanthin production inducers was determined by as-fabricated OECTs. This work may assist to develop a real-time biosensor to indicate the appropriate time to apply inducers for a maximum astaxanthin production of H. pluvialis cells.
A Quantitative Evaluation of Drive Pattern Selection for Optimizing EIT-Based Stretchable Sensors
Authors: Russo Stefania , Nefti-Meziani Samia , Carbonaro Nicola , Tognetti Alessandro
Published: August 2017

Electrical Impedance Tomography (EIT) is a medical imaging technique that has been recently used to realize stretchable pressure sensors. In this method, voltage measurements are taken at electrodes placed at the boundary of the sensor and are used to reconstruct an image of the applied touch pressure points. The drawback with EIT-based sensors, however, is their low spatial resolution due to the ill-posed nature of the EIT reconstruction. In this paper, we show our performance evaluation of different EIT drive patterns, specifically strategies for electrode selection when performing current injection and voltage measurements. We compare voltage data with Signal-to-Noise Ratio (SNR) and Boundary Voltage Changes (BVC), and study image quality with Size Error (SE), Position Error (PE) and Ringing (RNG) parameters, in the case of one-point and two-point simultaneous contact locations. The study shows that, in order to improve the performance of EIT based sensors, the electrode selection strategies should dynamically change correspondingly to the location of the input stimuli. In fact, the selection of one drive pattern over another can improve the target size detection and position accuracy up to 4.7% and 18%, respectively.