bluuebunny/crossref_metadata_2025 huggingface dataset:
Following Ernst Haeckel: The “Monistic Ethics” of Heinrich Schmidt
Authors:   Friedrich-Schiller University Jena, Hossfeld Uwe , Levit Georgy S. ,   Friedrich-Schiller University Jena
Published: October 2023

The article scrutinizes the ethical conception of Heinrich Schmidt (1874–1935), a student of “German Darwin” Ernst Haeckel. Haeckel was not only an eminent champion of Darwinism, but also a philosopher who created a universal evolutionism, or “monism”. Haeckel’s doctrine is founded on the concept of evolution as a universal phenomenon, including everything from inorganic matter to the human beings. He believed in the unity of body and soul, as well as in the unity of spirit and matter. The acceptance of substantial monism as a scientific metamethodology and the basis of a new Weltanschauung was accomplished by Haeckel’s philosophical achievement. Haeckel united matter, energy and psychoma (i. e. world soul) into the trinity of substance, thus covering all the basic physical and mental properties within the framework of one doctrine. All three elements correspond with the certain laws of conservation: the conservation of matter, energy, and psychoma or Empfindung (i. e. perception). To Haeckel, his monistic perspective reconciles the “old” disputes between materialism, energy and panpsychism. Schmidt, Haeckel’s immediate student, tried to further develop Haeckel’s philosophy and proposed an integral monistic doctrine. Schmidt proceeded from Haeckel’s principle of substance, leading to the idea of material evolution towards ever greater perfection and, consequently, the emergence of the human mind and associated with it infinitely self-improving science and culture. Accordingly, the moral (the good) is what leads to the preservation and improvement of existence. The evolution of human society follows the direction of “the good”, understood as harmony, while “evil” is the absence of harmony. He expressed this idea in his main ethical work The Search for Harmony in Monistic Ethics. In his later writings, Schmidt made efforts to adapt monist ethics to the ideology of National-Socialism. The failure of those attempts is a historical and philosophical argument in favor of the concept of the fundamental incompatibility of Haeckeliantype monism and Nazism.
The ethics of risk in Robert Nozick’s “Anarchy, the State, and Utopia”
Authors:   St. Petersburg State University, Sunami Artem N. , Osipov Igor D. ,   St. Petersburg State University
Published: October 2023

The article is devoted to the analysis of the ethical concept of risk presented in the central work of R. Nozick “Anarchy, the State and Utopia” (1974) (chapter “Prohibition, compensation and risk” and prerequisites), one of the most influential representatives of modern Western political philosophy. Despite the fact that, along with the “A Theory of Justice” by J. Rawls, this work is the most important for the modern Western discourse on the moral foundations of politics, the concept of risk included in it as a necessary element has almost never been the subject of detailed consideration in the domestic research tradition. Referring to modern academic discussion, built around the idea of “risk society” by U. Beck and other risk theories, the authors correlate the key issues of equity in the production and consumption of risks, their distribution, conflict interaction of the parties to risk relations with the R. Nozick’s provisions. The article traces the path traversed by R. Nozick from posing the question of the necessity of the state as such to the moral foundations of prohibition, risk and compensation in a “state of nature”. It examines the possible reactions outlined by the philosopher to risky actions and the collisions of their moral justification. As a result of the analysis, the authors conclude that R. Nozick’s ethical concept of risk allows us to identify some key features, without answering to which it will be impossible to establish morally justified regulators of risk relations: 1) is a fair system of risk distribution possible in principle and compensation; 2) whether it is necessary to include risk reflection in the exchange package, that is, the fear experienced by potential victims of a risky action.
Foucault’s biopolitics as neoliberalism and the twenty-first century
Authors:   University of Belgrade, Koljević Griffith Bogdana N.
Published: October 2023

In this article, the author articulates Foucault’s theory of biopolitics as neoliberalism and argues that it is simultaneously the most comprehensive theory of biopolitics and the most instructive theory for political philosophy in the twenty-first century. More precisely, the analysis of biopolitical governmentality in Foucault’s different works reveals the continuation between the archeology of knowledge and genealogy of power, bringing forth the issue of political subjectivity and politics per se. It is argued that Foucault’s project presents an unfinished project of Modernity and that, as such, it opens the possibility of a different rationality with the affirmation of the idea of legitimacy. The movement from sovereignty to biopolitics for Foucault is relevant as the destruction of the legal system and the distancing from philosophy. Furthermore, these are key characteristics of the new Western discourse which at the same time is structured on the system of binary oppositions and discloses itself as a counter-history. In Foucault’s project by contrast, the potentiality for a new political subjectivity arises from the interrelations between scientific knowledge and knowledge of the people (local memories). Political realism is the result of his elaboration of utilitarian vs revolutionary course. Finally, contemporary phenomena of biopolitics are presented, most notably Western ‘humanitarian interventions’, political trials, the control and regulation of population in the Coronavirus crisis, bioterror, and the artificial difference between democracy and authoritarianism.
Comparison of economic benefits for the utilization of reclaimed resources from wastewater treatment plants: a case study in Beijing
Authors: Hu Yongfeng , Zhang Yongxiang , Wang Kun
Published: October 2023

The fate of resource recovery is significantly influenced by the standards of water quality and bio-dried excess sludge for various applications. These standards must be practically attainable while ensuring public and environmental health, safety, and economic advantages. The present study investigates a reclaimed wastewater treatment plant (WWTP) in Beijing that incorporates both reclaimed water utilization facility and bio-dried excess sludge treatment. The study elucidates the standards for reclaimed water quality and bio-dried excess sludge for diverse applications. Notably, reclaimed water demonstrates substantial market demand in terms of economic benefits. However, bio-dried excess faces challenges due to higher operational costs and lower TP content. The heat power of the WWTP effluent water source can not only be harnessed for the bio-drying process blowers but also be elevated air temperatures to expedite the bio-drying process.
Исследование факторов риска, способствующих нарушению психологической безопасности у мирного населения прифронтовых территорий
Authors: Колобова Светлана В. , Ичитовкина Елена Г.
Published: October 2023

Актуальность данной работы заключается в том, что в ситуации вооруженного конфликта жители прифронтовых территорий оказываются в положении политической нестабильности, что несет угрозу нарушения их психологической безопасности, которая, в свою очередь, может повлечь состояние стресса и нарушение всех аспектов здоровья личности. В данной работе под психологической безопасностью мы понимаем состояние личности, имеющее личностный и ситуативный уровень проявления, формирование которого обусловлено развитием человека в онтогенезе, находится под воздействием факторов внешней среды, внутриличностных паттернов и выраженное в устойчивости, сопротивляемости негативным воздействиям, в эффективности и активности деятельности и восприятии собственной защищенности. В данной статье представлено исследование факторов риска, способствующих нарушению психологической безопасности у мирного населения прифронтовых территорий, а также проведен сравнительный анализ уровня нервно-психической адаптации у жителей регионов, территориально приближенных к зоне ведения боевых действий, и жителей Москвы и Московской области. В результате исследования было выявлено, что у жителей прифронтовых территорий выраженность проблемно-ориентированного копинга, эмоционально-ориентированного копинга, копинга, ориентированного на избегание, существенно выше, чем у жителей Москвы и Московской области. Кроме того, показатели субшкалы «Отвлечение» и «Социальное отвлечение» также значимо выше у мирных жителей, проживающих в близости ведения боевых действий, учитывая, что уровень нервно-психической адаптации в обеих группах отличается не значимо и соответствует норме. Новизна исследования заключается в том, что впервые исследованы факторы нарушения психологической безопасности мирных жителей, проживающих на территориях, приближенных к зоне ведения специальной военной операции.
Стратегии преодоления трудных жизненных ситуаций у мужчин и женщин с алкогольной зависимостью
Authors: Бордоносенко Анастасия С.
Published: October 2023

Современные условия жизни так или иначе сопряжены со стрессом, трудностями и особенности поведения личности в подобных обстоятельствах могут выступать факторами успешного, адаптивного функционирования. К настоящему моменту копинг или совладающее поведение личности описаны подробно как зарубежными, так и отечественными учеными. Однако разработка указанной проблемы применительно к аддиктивной категории населения производится лишь в последние десятилетия и на данном этапе несколько фрагментарна. Представленная статья посвящена изучению особенностей преодоления трудных жизненных ситуаций алкозависимых пациентов. В работе подробно изложены результаты исследования взаимосвязи алкоголизма и стратегий преодоления трудных жизненных ситуаций у мужчин и женщин. Новизна работы состоит в попытке расширения и уточнения имеющихся данных в контексте исследования стратегий преодоления трудных жизненных ситуаций у мужчин и женщин с алкогольной зависимостью. Исследование проводится с учетом половой дифференциации респондентов, что дает основание для более детального изучения особенностей преодоления трудных жизненных ситуаций. Исходя из этого, представляется возможным учет полученных данных в аспекте составления реабилитационной и психотерапевтической программы воздействия на алкозависимую личность, результаты могут быть полезны в случае проведения психокоррекции и обучения пациентов навыкам использования адаптивных и социально приемлемых стратегий поведения. Проведенное исследование позволяет отметить значимые различия в преодолении трудных жизненных ситуаций у неалкоголизированных и алкозависимых респондентов. Высокая склонность к конфронтации при низком самоконтроле в сочетании с поиском социальной поддержки, направленной на алкогольную микросреду – лишь некоторые особенности поведения больных в трудных жизненных ситуациях.
concepções de ensino híbrido na educação brasileira
Authors: Caldeira Elisa Maia Velloso , Vieira Fábia Magali Santos
Published: October 2023

A partir das medidas de enfrentamento da pandemia em 2020, a adoção do ensino híbrido tornou-se um dos temas de pauta nas agendas educacionais. Entretanto, essa modalidade de ensino acarreta incertezas e dificuldades na realização de práticas emancipatórias. Conceituar ensino híbrido não constitui uma tarefa fácil: vários autores a conceituam de maneiras diferentes. Com o objetivo de identificar as concepções de ensino híbrido que têm predominado na educação brasileira nos últimos 10 anos, realizou-se uma Revisão Sistemática da Literatura (RSL) na Biblioteca Digital Brasileira de Teses e Dissertações (BDTD) e Google Scholar, e foram identificados trabalhos que apresentam concepções superficiais de ensino híbrido e outros, como Moura (2018); Costa (2019) e Fialho (2020), que, fundamentados em Moran (2015), defendem uma nova visão sobre ensino híbrido, que entende a hibridação como um processo sócio-cultural, cujas estruturas e práticas, uma vez separadas, combinam-se para gerar novas estruturas, objetos e práticas.
Evaluation of Flavonoid-rich Fraction of Portulaca Grandiflora Aerial Part
Extract in Atherogenic Diet-induced Atherosclerosis
Authors: Wang Xiuping , Sharma Aishwarya , Liu Yongchao , Wang Xiaoying , Kumari Deepika , Kainth Ritu
Published: October 2023

Background::

Portulaca grandiflora is a tiny, upright herb that contains a variety of
chemical components, including alkaloids, glycosides, mucilage, proteins, tannins, flavonoids,
saponins, polysaccharides, and triterpenoids possessing properties that may help with atherosclerosis.
The reported pharmacological properties of Portulaca grandiflora are antioxidant, antidiabetic,
antiasthmatic, antibacterial, antiulcer and anti-inflammatory properties.

Objectives::

The yield of methanol extract is higher than that of ethanol and acetone, and its phytoconstituents,
like flavonoids and polyphenols, and has potent antioxidant properties. In order to
determine the effectiveness of Portulaca grandiflora methanol extract fraction against high-fat
diet (HFD)-induced hyperlipidemia, hemodynamic change, antioxidant levels, and vascular dysfunction
in rats, a study was carried out on a flavonoid-rich methanol extract fraction of the aerial
part of Portulaca grandiflora Hook

Methods::

This method involves a study of 30 days involving male Wistar rats (240–250 g) (n=5)
that were fed with an Ath diet. Study groups were divided into (i) The Control Group, (ii) the
Diseases Control Group, (iii) Disease + Standard drug (Atorvastatin 20mg/kg, orally, (iv) Disease
+ Test Extract dose 1 (Portulaca grandiflora 200 mg/kg orally), and (v) Disease + Test Extract
dose 2 (Portulaca grandiflora 400 mg/kg orally). Both the test drug Portulaca grandiflora
and the standard drug Atorvastatin were given orally for 30 days.

Results::

At the end of the study, blood samples were taken to measure the serum lipid profile,
alanine aminotransferase, aspartate aminotransferase, lactate dehydrogenase, and levels of oxidative
tissue stress. Hemodynamic parameters and aortic staining were performed. Portulaca grandiflora
treatment improved the lipid profile and considerably reduced oxidative stress levels.
Aortic staining examination revealed a marked reduction in atherosclerotic lesions.

Conclusion::

These results revealed that Portulaca grandiflora is an effective treatment approach
in preventing atherosclerotic lesion progression, which is attributed to its protection against oxidative
stress and various enzymatic activities in the Atherogenic model.
An Exploration of Organoid Technology: Present Advancements,
Applications, and Obstacles
Authors: Mishra Isha , Gupta Komal , Mishra Raghav , Chaudhary Kajal , Sharma Vikram
Published: October 2023

Background:

Organoids are in vitro models that exhibit a three-dimensional structure
and effectively replicate the structural and physiological features of human organs. The capacity
to research complex biological processes and disorders in a controlled setting is laid out by these
miniature organ-like structures.

Objectives:

This work examines the potential applications of organoid technology, as well as the
challenges and future directions associated with its implementation. It aims to emphasize the
pivotal role of organoids in disease modeling, drug discovery, developmental biology, precision
medicine, and fundamental research.

Methods:

The manuscript was put together by conducting a comprehensive literature review,
which involved an in-depth evaluation of globally renowned scientific research databases.

Results:

The field of organoids has generated significant attention due to its potential applications
in tissue development and disease modelling, as well as its implications for personalised
medicine, drug screening, and cell-based therapies. The utilisation of organoids has proven to be
effective in the examination of various conditions, encompassing genetic disorders, cancer, neurodevelopmental
disorders, and infectious diseases.

Conclusion:

The exploration of the wider uses of organoids is still in its early phases. Research
shall be conducted to integrate 3D organoid systems as alternatives for current models, potentially
improving both fundamental and clinical studies in the future.
Gut Microbiome and Circadian Interactions with Platelets Across Human
Diseases, including Alzheimer’s Disease, Amyotrophic Lateral Sclerosis,
and Cancer
Authors: Anderson George
Published: October 2023

Platelets have traditionally been investigated for their role in clot formation in the
course of cardiovascular diseases and strokes. However, recent work indicates platelets to be an integral
aspect of wider systemic processes, with relevance to the pathophysiology of a host of diverse
medical conditions, including neurodegenerative disorders and cancer. This article reviews
platelet function and interactions with the gut microbiome and circadian systems, highlighting the
role of the platelet mitochondrial melatonergic pathway in determining platelet activation, fluxes
and plasticity. This provides a number of novel conceptualizations of platelet function and mode
of interaction with other cell types, including in the pathoetiology and pathophysiology of diverse
medical conditions, such as cancer, Alzheimer’s disease, and amyotrophic lateral sclerosis. It is
proposed that a platelet-gut axis allows platelets to contribute to many of the pathophysiological
processes linked to gut dysbiosis and gut permeability. This is at least partly via platelet sphingosine-
1-phosphate release, which regulates enteric glial cells and lymphocyte chemotaxis, indicating
an etiological role for platelets in a wide array of medical conditions linked to alterations in
the gut microbiome. Platelets are also an important regulator of the various microenvironments
that underpin most human medical conditions, including the tumor microenvironment, neurodegenerative
diseases, and autoimmune disorders. Platelet serotonin release regulates the availability
of the mitochondrial melatonergic pathway systemically, thereby being an important determinant
of the dynamic metabolic interactions occurring across cell types that underpin the pathoetiology
of many medical conditions. In addition, a number of novel and diverse future research directions
and treatment implications are proposed.
Development and In Vitro Evaluation of Aceclofenac Buccal Film
Authors: Almurisi Samah Hamed , Mohammed Ayah , Qassem Farah , Jehad Heba , Jassim Asma , AL-Japairai Khater , Sammour Rana M.F.
Published: October 2023

Aim::

This study aimed to formulate and characterize aceclofenac buccal film formulations
made of different polymers and evaluate the effects of polymer type on buccal film properties.

Materials and Methods::

Five polymer types, namely hydroxypropyl methylcellulose (HPMC), sodium
carboxymethylcellulose (SCMC), polyvinyl alcohol (PVA), Eudragit S100, and Eudragit
SR100, were used to prepare aceclofenac buccal film formulation either separately or combined by
solvent-casting method. These formulations were evaluated in terms of physical appearance, folding
test, film weight and thickness, drug content, percentage of elongation, moisture uptake, water vapor
permeability, and in vitro drug release.

Results::

The addition of Eudragit polymer in most of the produced buccal films was unacceptable
with low folding endurance. However, the dissolution profile of buccal films made from PVA and
Eudragit SR100 provided a controlled drug release profile.

Conclusion::

Buccal films can be formulated using different polymers either individually or in combination
to obtain the drug release profile required to achieve a desired treatment goal. Furthermore,
the property of the buccal films depends on the type and concentration of the polymer used.
Prepubertal Continuous Dietary Folate Fortification Enhances the Brain
Function of Adult Mice by Modulating Antioxidant Status, Inflammation,
and Brain Neurotransmitter Levels
Authors: Onaolapo Olakunle J. , Olofinnade Anthony T. , Ojo Folusho O. , Falade Joshua , Onaolapo Adejoke Y.
Published: October 2023

Background::

The benefits of folic acid supplementation have been documented in several
studies. However, while evidence exists regarding its benefits for growth and haematologic
parameters, its possible effects on the brain have been less examined.

Objectives::

The study aimed to examine the benefits of dietary folic acid supplementation (beginning
in the prepubertal period) on neurobehaviour, oxidative stress, inflammatory parameters, and
neurotransmitter levels in adult mice.

Methods::

Forty-eight prepubertal male mice were assigned into four groups of 12 animals each.
Mice were grouped into normal control (fed standard diet) and three groups fed folic acid supplemented
diet at 2.5, 5, and 10 mg/kg of feed. Animals were fed a standard diet or folic acid-supplemented
diet for eight weeks during which food intake and body weight were assessed. On postnatal
day 78, animals were exposed to the open-field, Y-maze, radial arm maze, elevated plus maze, bar
test, and models of behavioural despair. 24 hours after the last behavioural test, animals were made
to fast overnight and then sacrificed by cervical dislocation. Blood was then taken for the assessment
of blood glucose, leptin, and insulin levels. Homogenates of brain tissue were prepared and used for
the assessment of biochemical parameters.

Results::

Results showed a concentration-dependent increase in body weight, and improved antioxidant
status, memory scores, and acetylcholine levels. Also, a decrease in food intake, blood glucose,
insulin, and leptin levels was observed. A reduction in open-field behaviour, anxiety-related behaviour,
and proinflammatory markers, was also observed.

Conclusion::

The beneficial effect of prepubertal continuous dietary folate fortification on the brain
(as the animal ages) has been shown in this study.
Multi-Degree-of-Freedom Platforms: Development and Outlook
Authors: Zhang Yuan , Qu Yuanxin , Wang Xiaolong , Liu Ziqi
Published: October 2023

Background:

Multi-degree-of-freedom platforms are frequently employed in space
docking devices, motion modeling, and robotics. Complex research is being done on multidegree-
of-freedom platforms, including work on spatial route creation, control simulation, and
forward and backward platform motion solutions. The development of research platforms in their
current state is advantageous for advancing multi-degree-of-freedom motion research, which has
the potential to advance numerous sectors through new technology.

Objective:

In this patent study, the benefits and drawbacks of various platforms are explored to
analyze the development trend of platforms for academics and engineers through the most recent
development of multi-degree-of-freedom platforms.

Methods:

By using the research methodology, research substance, and inventive structure of the
most recent representative patents of the multi-degree-of-freedom platform, the platform's operating
principle and characteristics are demonstrated.

Results:

By contrasting multi-degree-of-freedom platforms in various application domains, the
issues with current multi-degree-of-freedom platforms are enumerated, and the platforms' potential
future development path and research topics are suggested.

Conclusion:

The growth of the aviation, medical, and military industries is aided by the development
of multi-degree-of-freedom platforms, and the flexible distribution of high-precision parallel
platforms has promising future development.
Osthole: A Medicinally Privileged Natural Compound with its Therapeutic
Potential
Authors: Ansari Kamran , Gupta Ujjwal , Sinha Antra , Sharma Ankit , Rahate Kalpana
Published: October 2023

Osthole is a coumarin derived natural compound which is an essential ingredient of Traditional
Chinese Medicine (TMC) and is widely distributed in nature in plants like Cnidium monnieri
(L) Cusson and Angelica pubescens. Current study presents a critical review on description of pharmacological
importance of osthole, which is reported to exhibit anticancer, antioxidant, osteogenic,
hepatoprotective, neuroprotective, cardiovascular protective, antimicrobial, immuno-modulatory and
anti-inflammatory activities. Till date, the reports include pharmacological properties, brief chemistry
of advanced methods to explore osthole content in variety of plants. Present review seeks to highlight
the sources, biosynthesis, extraction methods, pharmacological properties of the molecule and
its derivatives. A brief discussion on patents recently published and granted on the molecule has also
been highlighted. Thus the overview of the literature presents the analysis about future possible modalities
of the research on this molecule.
Current Trends on Innovative Technologies in Topical Wound Care for
Advanced Healing and Management
Authors: Saifullah Qazi , Sharma Abhishek
Published: October 2023

Objective:

To investigate critically traditional and modern techniques for cutaneous
wound healing and to provide comprehensive information on these novel techniques to encounter
the challenges with the existing wound healing methods.

Significance:

The financial burden and mortality associated with wounds is increasing, so managing
wounds is essential. Traditional wound treatments include surgical and non-surgical
methods, while modern techniques are advancing rapidly. This review examines the various
traditional and modern techniques used for cutaneous wound healing.

Key Findings:

Traditional wound treatments include surgical techniques such as debridement,
skin flaps, and grafts. Non-surgical treatments include skin replacements, topical formulations,
scaffold-based skin grafts, and hydrogel-based skin dressings. More modern techniques include
using nanoparticles, growth factors, and bioactive substances in wound dressings. Bioengineered
skin substitutes using biomaterials, cells, and growth factors are also being developed.
Other techniques include stem cell therapy, growth factor/cytokine therapy, vacuum-assisted
wound closure, and 3D-printed/bio-printed wound dressings.

Conclusion:

Traditional wound treatments have been replaced by modern techniques such as
stem cell therapy, growth factor/cytokine therapy, vacuum-assisted wound closure, and bioengineered
skin substitutes. However, most of these strategies lack effectiveness and thorough
evaluation. Therefore, further research is required to develop new techniques for cutaneous
wound healing that are effective, cost-efficient, and appealing to patients.
Melatonin and Related Compounds as Antioxidants
Authors: Barbarossa Alexia , Carrieri Antonio , Carocci Alessia
Published: October 2023

Oxidative stress has been reported to be involved in the onset and development of several
diseases, including neurodegenerative and cardiovascular disorders, some types of cancer, and diabetes.
Therefore, finding strategies to detoxify free radicals is an active area of research. One of these
strategies is the use of natural or synthetic antioxidants. In this context, melatonin (MLT) has been
proven to possess most of the required characteristics of an efficient antioxidant. In addition, its protection
against oxidative stress continues after being metabolized, since its metabolites also exhibit
antioxidant capacity. Based on the appealing properties of MLT and its metabolites, various synthetic
analogues have been developed to obtain compounds with higher activity and lower side effects. This
review addresses recent studies with MLT and related compounds as potential antioxidants.
A R T I C L E H I S T O R Y
Received: March 25, 2023
Revised: May 06, 2023
Accepted: May 30, 2023
DOI:
10.2174/1389557523666230627140816
Keywords: Melatonin, circadian rhythms, indole nucleus, antioxidants, oxidative stress, radical scavengers, neurodegenerative
Introduction to Artificial Intelligence
Authors: Nagaraj Ambika
Published: October 2023

The term manufactured brilliance connotes both opportunities and threats to
humanity. As a global trend, intelligence is becoming relevant at almost every level of
social behavior, raising both high expectations and serious concerns. Numerous
algorithms, models and methods, as well as machine learning, databases, and
visualizations, are reflected in artificial intelligence. One of the main benefits is that
AI-driven machines adhere to consistently rational algorithmic rules without being
biased. Ethical considerations aim to instill morality in machines and make AI-driven
robots more human. The process of simulating human intelligence using machines,
particularly computer systems, is known as artificial intelligence. Expert systems,
natural language processing, speech recognition, and machine vision are some specific
applications of cleverness. This chapter explains its working, issues faced by the same
and challenges of the technology
Internet of Things (IoT) with AI
Authors: Nagaraj Ambika
Published: October 2023

The web of things and man-made brainpower are a couple of innovations
that together structure, alluded to as Industry 4.0. These support points incorporate the
modern web of things, information, and investigation, whereas the last option can
incorporate synthetic intelligence and its techniques. Artificial intelligence is the cycle
of creating clever machines and performing assignments of human knowledge, for
example, direction, discourse acknowledgment, etc. This cycle has to think and be
capable of self-remedy. Learning is the securing of data and rules for employing the
information; thinking is rules to arrive at rough or distinct resolutions. AI is utilized in
different areas of trend-setting innovations, for example, blockchain thinking,
decentralized AI, the intellectual prowess of things, machines, etc. Coordination of AI
and IoT gives the best approach to gathering the data, examining it, and observing the
proper realization of utilized for applications like medical care, home, shrewd
cultivating, and astute vehicles. This chapter explains the architecture, applications, use
cases, challenges and open issues of the integration.
Cloud with AI
Authors: Nagaraj Ambika
Published: October 2023

Distributed computing is essential in our present-day lives as it empowers a
scope of utilizations from framework to virtual entertainment. Such framework should
adapt to changing burdens and developing use mirroring social orders' communication
and reliance on robotized figuring frameworks while fulfilling the nature of
administration requirements. Empowering these frameworks is a companion of
practical innovations orchestrated to satisfy the need to develop registering
applications. There is a need to distinguish fundamental advances in licensing future
applications. Cloud suppliers, for example, Facebook, Google and Amazon, use an
enormous scope of Cloud Server farms to arrange heterogeneous nature administration
requirements. Cloud registering stages can give a bound-together connection point over
heterogeneous assets found in the Web of Things-based applications, which work on
the dependability of cloud administrations. This chapter discusses cloud-AI
architecture, applications, challenges and future directions. 
Review article on Viruddha Ahara
Authors: Kamlesh Kumar Meena  , Ritu Kapoor  , Devender Singh Chahar
Published: October 2023

Ahara (food) is the prime need for the sustaining of life. Ayurveda explained about Trividha Upasthambha (sub-pillars of body) and Ahara (food) is one of the important pillars for healthy living being. For healthy living Ayurveda emphasizes on consuming right kind of diet which provide health and nutrition. The diet which disturbs the balance among the body elements is called Viruddha Ahara (Incompatible diet). Consuming two food items together or a particular type of diet may tend to toxicity; it is termed as incompatible diet. Even incompatible diet should be considered similar to Gara Visha (Artificial poison). Viruddha (Incompatible diet) means substances which when consumed cause for aggravations of Doshas but do not expel them out of the body and bring about abnormalities in Dhatu (tissues of the body). The incompatible diet could be considered similar to poison and artificial poisoning if taken simultaneously and continuously. Due to western lifestyle there is extensive exposure to toxins. The present article deals with the review of Viruddha Ahara (Incompatible diet) referred in context of Viruddha Aaharajanit Vyadhis (Incompatible food induced diseases) and its prevention in Brihattrayi.
To evaluate the effect of Nimbadi Pindi and Patoladi Kashaya Parisheka in the management of Anjananamika (External Hordeolum) - A Single Case Study
Authors: Amol Bansode  , Vaijwade AP
Published: October 2023

Anjananamika is a Raktapradhana Vartmagata Sadhya Netra Vikara caused by the vitiation of Rakta and Mamsa of Vartma due to improper Ahara and Viharas. The Lakshanas of Anjannamika appears to be similar to that of External Hordeolum, acute suppurative inflammation of the eyelash follicles and its associated glands of Zeis or Moll. It is a Raktapradhana Vyadhi along with the involvement of other Doshas, Pittahara and Doshahara treatment can be done. All the drugs in Nimbadi Pindi and Patoladi Kashaya Parisheka are Chakshushya and have Pitta Shamaka properties. The case selected in this study, patient has been suffering from pain, foreign body sensation, discomfort, congestion, mild watering and photophobia in the upper palpebral conjunctiva of the right eye. Nimbadi Pindi and Parisheka were administered once a day for 7 days, with follow up of one week in Anjananamika. Here, a sincere effort is made to evaluate the effect of Nimbadi Pindi and Patoladi Kashaya Parisheka. This study showed that both Nimbadi Pindi and Patoladi Kashaya Parisheka have significant effect in Anjananamika.
ÖĞRETMEN ADAYLARINA YÖNELİK AKILLI TELEFONLARIN TASARIMINDA GÜVENLİK BEKLENTİLERİ ÖLÇEĞİNİN (ATTGBÖ) GELİŞTİRİLMESİ
Authors: Tozkoparan Süleyman Burak , Odabaşı Ferhan , Kurt Adile Aşkım
Published: October 2023

Bu çalışmada öğretmen adaylarının akıllı telefonların tasarımında güvenlik beklentilerini belirlemek için bir ölçme aracı geliştirilmesi amaçlanmıştır. Ölçeğin geliştirilme sürecinde karma yöntem benimsenmiş, sıralı keşfedici desen kullanılmıştır. Bu süreçte alanyazın taraması yapılmış, dört adet odak grup görüşmesi gerçekleştirilmiştir. Alanyazın ve odak grup görüşmelerinden dayanak alınarak oluşturulan madde havuzunun dil ve kapsam geçerliğinin irdelenmesi ve pilot çalışmanın gerçekleştirilmesi sonrasında 44 önermeden oluşan 5’li likert tipinde düzenlenmiş taslak ölçek oluşturulmuştur. Veri toplama uygulamaları Eskişehir Osmangazi ve Anadolu Üniversitelerindeki öğretmen adaylarıyla yürütülmüştür. 1. uygulama ile 360 öğretmen adayına uygulanan taslak ölçek üzerinde açımlayıcı faktör analizi yapılmış, ölçeğin madde ve faktör yapısına ulaşılmıştır. 2. uygulamada 293 öğretmen adayından toplanan veri üzerinde doğrulayıcı faktör analizi yapılmış, beş faktör ve 21 maddeden oluşan Akıllı Telefonların Tasarımında Güvenlik Beklentileri Ölçeğine (ATTGBÖ) doğrulanmıştır. ATTGBÖ’nün alt boyutları “kullanıcıya özgü beklentiler”, “cihaza özgü beklentiler”, “entegrasyon beklentileri”, “sağlığa özgü beklentiler” ve “destek beklentileri” şeklindedir. Ölçeğin son haline ait Cronbach’s Alpha güvenirlik katsayısı 1. uygulama veri seti için .88, 2. uygulama veri seti için .85’tir. ATTGBÖ’nün akıllı telefonların tasarımı ve güvenlik beklentileriyle ilgili yapılacak çalışmalara katkı sunabileceği düşünülmektedir.
Skrb o odrasloj djeci s invaliditetom
Authors: Ombla Jelena
Published: October 2023

Roditeljska skrb o odraslom djetetu s invaliditetom predstavlja izuzetne zahtjeve i odgovornost, što se može nepovoljno odraziti na njihovo tjelesno i psihičko funkcioniranje. Pritom je opterećenje njegovatelja veće kod onih roditelja koji skrbe o starijoj u odnosu na mlađu djecu, zbog kumulativnih efekata stresa te rastuće brige roditelja za nesigurnu budućnost njihove djece koja stare. S obzirom na to da cjelovita skrb o odrasloj djeci s invaliditetom predstavlja značajni psihofizički izazov za zdravlje starijih roditelja, te uzevši u obzir rezultate istraživanja koji ukazuju na značenje podrške sredine, cilj ovog istraživanja bio je ostvariti inicijalni uvid u problematiku skrbi o odrasloj djeci/osobama s invaliditetom unutar okvira javnog i privatnog sektora u RH i to iz perspektive roditelja njegovatelja. U istraživanju su sudjelovala 72 roditelja (67 žena) prosječne dobi od oko 53 godine, koji u potpunosti skrbe o svom odraslom djetetu s invaliditetom. Podaci su prikupljeni online metodom. Tematska analiza odgovora na temeljno istraživačko pitanje pokazuje kako manji udio roditelja iskazuje opće zadovoljstvo sa skrbi, dok većina roditelja navodi razloge nezadovoljstva sa skrbi koju njihovo dijete ostvaruje kao osoba s invaliditetom. Preliminarnim uvidom u aspekte formalne skrbi prema osobama s invaliditetom, iz perspektive roditelja, ostvaren je znanstveni doprinos u vidu empirijskih smjernica za buduća istraživanja ove tematike, dok zaključci mogu poslužiti pri daljnjem razvoju bioetičkog znanstveno-stručnog diskursa te, shodno tome, i analizama i evaluaciji postojećih socijalnih politika.
Coadaptation Between Smart Technologies and Older Adults Over Time: Protocol for a Scoping Review (Preprint)
Authors: Kokorelias Kristina Marie , Grigorovich Alisa , Harris Maurita T , Rehman Umair , Ritchie Louise , Levy AnneMarie , Denecke Kerstin , McMurray Josephine
Published: October 2023

BACKGROUND

The Internet of Things (IoT) has gained significant attention due to advancements in technology and has potential applications in meeting the needs of an aging population. Smart technologies, a subset of IoT, can support older adults in aging in place, promoting independent living and improving their quality of life. However, there is a lack of research on how older adults and smart technologies coadapt over time to maximize their benefits and sustain adoption.

OBJECTIVE

We will aim to comprehensively review and analyze the existing scientific literature pertaining to the coadaptation between smart technologies and older adults. The primary focus will be to investigate the extent and nature of this coadaptation process and explore how older adults and technology coevolve over time to enhance older adults' experience with technology.

METHODS

This scoping review will follow the methodology outlined in the Joanna Briggs Institute Reviewer's Manual and adhere to the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analysis Extension for Scoping Reviews) guidelines for reporting. Peer-reviewed articles will be searched in databases like Ovid MEDLINE, OVID Embase, PEDro, OVID PsycINFO, EBSCO CINAHL, the Cochrane Library, Scopus, IEEE Xplore, Web of Science, and Global Index Medicus. The research team will create a data extraction form covering study characteristics, participant characteristics, underlying models and frameworks, research findings, implications for technology coadaptation, and any identified study limitations. A directed content analysis approach will be used, incorporating the Selection, Optimization, and Compensation framework and Sex- and Gender-Based Analysis Plus theoretical framework.

RESULTS

The results of this study are expected in January 2024.

CONCLUSIONS

This scoping review endeavors to present a thorough overview of the available evidence concerning how smart technologies interact with older adults over an extended period. The insights gained from this review will lay the groundwork for a research program that explores how older adults adapt to and use smart technologies throughout their lives, ultimately leading to improved user satisfaction and experience and facilitating aging in place with tailored support and user-centered design principles.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/51129
Development and Usability of the OHiFamily Mobile App to Enhance Accessibility to Maternal and Infant Information for Expectant Families in Ohio: Qualitative Study (Preprint)
Authors: Perme Natalie , Reid Endia , Eluagu Macdonald Chinwenwa , Thompson John , Hebert Courtney , Gabbe Steven , Swoboda Christine Marie
Published: October 2023

BACKGROUND

The Infant Mortality Research Partnership in Ohio is working to help pregnant individuals and families on Medicaid who are at risk for infant mortality and preterm birth. As part of this initiative, researchers at The Ohio State University worked to develop a patient-facing mobile app, OHiFamily, targeted toward, and created for, this population. To address the social determinants of health that can affect maternal and infant health, the app provides curated information on community resources, health care services, and educational materials in a format that is easily accessible and intended to facilitate contact between families and resources. The OHiFamily app includes 3 distinct features, that is, infant care logging (eg, feeding and diaper changes), curated educational resources, and a link to the curated Ohio resource database (CORD). This paper describes the development and assessment of the OHiFamily app as well as CORD.

OBJECTIVE

This study aimed to describe the development of the OHiFamily mobile app and CORD and the qualitative feedback received by the app’s intended audience.

METHODS

The researchers performed a landscape analysis and held focus groups to determine the resources and app features of interest to Ohio families on Medicaid.

RESULTS

Participants from several focus groups were interested in an app that could offer community resources with contact information, information about medical providers and information and ways to contact them, health tips, and information about pregnancy and infant development. Feedback was provided by 9 participants through 3 focus group sessions. Using this feedback, the team created a curated resource database and mobile app to help users locate and access resources, as well as access education materials and infant tracking features.

CONCLUSIONS

OHiFamily offers a unique combination of features and access to local resources for families on Medicaid in Ohio not seen in other smartphone apps.
"Modulating Cancer Cell Cycle: Arresting and Shifting Rapid Dividing Cells to G0 Phase": A Review Article (Preprint)
Authors: Wahid Muhammad Hassan , khan Israr ahmad , Shuaib Mohammad Shumaq , ullah Rehan , khan Adnan , shah Muhammad Maarij
Published: October 2023

UNSTRUCTURED

In the rigid battle against cancer, an innovative strategy has emerged, one that seeks to harness the details of the cancer cell cycle to control its relentless growth. This review boards on a thorough exploration of the current landscape by studying the literature, aiming to shed light on manipulating cancer cells' division through the induction of a pause or rapid transition into the G0 phase. By meticulously evaluating existing studies, the authors navigate through various aspects, including the examination of malignant cells in early stages, clinical trials involving G0 phase-targeting chemotherapy, and the modulation of cell signaling mechanisms pivotal to the cell cycle. With a systematic approach, the investigation unfolds through in vitro experimentation and escalates into in vivo assessment, providing a comprehensive understanding of the subject matter. Crossing over the curve of the past five decades, this review dissects the trends in research, highlighting the evolution of insights into the complexities of the cancer cell cycle. However, among the endeavors to unravel its complexities, significant gaps and limitations remain. These gaps encompass the insufficient documentation of ontogeny, proto-oncogenes, and the complex process of carcinogenesis, evidence of the multifaceted challenges that persist in this field.
A Web-Based Intervention Based on Acceptance and Commitment Therapy for Family Caregivers of People With Dementia: Mixed Methods Feasibility Study (Preprint)
Authors: Atefi Golnaz. L , van Knippenberg Rosalia J M , Bartels Sara Laureen , Losada-Baltar Andrés , Márquez-González María , Verhey Frans R J , de Vugt Marjolein E
Published: October 2023

BACKGROUND

Acceptance and commitment therapy (ACT), as an empirically based third-wave cognitive behavioral therapy, has shown promise in enhancing well-being and functioning across diverse populations. However, in the context of caregiving, the effect size of available ACT interventions remains at best moderate, sometimes accompanied by high dropout rates, highlighting the need for more effective and feasible intervention designs.

OBJECTIVE

The objective of our study was to evaluate the feasibility and acceptability of a fully online ACT program designed for family caregivers of people with dementia. This study aimed to boost psychological flexibility and support caregivers, enabling them to realize and prioritize their own life values alongside their caregiving responsibilities.

METHODS

A mixed methods feasibility study using an uncontrolled pretest-posttest design was conducted. This intervention included a 9-week web-based self-help program based on ACT incorporating collaborative goal setting and weekly web-based motivational coaching for family caregivers of people with dementia. This study involved 30 informal caregivers recruited through memory clinics and social media platforms in the Netherlands and received approval from the Medical Ethics Committee of the Maastricht University Medical Center+ (NL77389.068.21/metc21-029).

RESULTS

A total of 24 caregivers completed the postintervention assessment, indicating a high adherence rate (24/29, 83%). Caregivers reported positive feedback regarding collaborative goal setting, but some found challenges in implementing new skills due to their own habitual responses or the unpredictable context of dementia caregiving. Personalizing the intervention based on individual value preferences was highlighted as beneficial.

CONCLUSIONS

Compared to other web-based self-help ACT interventions for family caregivers, this intervention showed a high adherence and sufficient level of feasibility, which underscores the use of personalization in delivering web-based interventions. Moreover, the potential of this ACT-based intervention for family caregivers of people with dementia was demonstrated, suggesting that further research and a larger-scale controlled trial are warranted to validate its effectiveness.

INTERNATIONAL REGISTERED REPORT

RR2-10.1136/bmjopen-2022-070499
Ezequiel Martínez Estrada: Cultura, política y redes intelectuales
Authors: Lamoso Adriana
Published: October 2023

Adriana Lamoso reconstruye los modos en que Martínez Estrada leía las situaciones sociopolíticas y culturales de la Argentina y Latinoamérica y la perspectiva moral desde la que expresaba sus evaluaciones y sanciones en sus ensayos más resonantes. La autora aborda el análisis del proceso simbólico de autofiguración como escritor e intelectual que Martínez Estrada construyó en sus escritos, así como el estudio el estudio de las redes de sociabilidad intelectual en las que se insertó. Esto permite hacer visibles sos posiciones estéticas, culturales y políticas, así como su conflictiva inserción en la tradición sarmientina, su posterior apertura a los países de América Latina y su radicación en México y Cuba.
¿EXISTE EL “NEOCONSTITUCIONALISMO”?
Authors: Manili Pablo Luis
Published: October 2023

El autor analiza las distintas opiniones doctrinarias relativas al neoconstitucionalismo, las razones esbozadas por los autores para sostener su existencia, las dudas que presentan algunos de ellos al respecto. En cada caso el autor expresa su discrepancia con las razones esgrimidas y finalmente concluye que ese término no describe ninguna realidad nueva en el derecho constitucional, sino que sólo alude a fenómenos que se vienen dando desde hace un siglo en la materia.