bluuebunny/crossref_metadata_2025 huggingface dataset:
History, current trends and prospects for the development of pro- and prebiotic drugs in Russia and abroad
Authors: Savinova Yu. S. , Belkova N. L. , Semenova N. V. , Rychkova L. V.
Published: December 2022

The gut microbiota is the largest human microbial community, comprising more than 1000 species of various microorganisms. It has been established that these are the gut microorganisms that play a decisive role in maintaining health, participating in the metabolism of proteins, carbohydrates, lipids, bile acids and the synthesis of vitamins. It has been shown that changes in the balance in the gut microbiocenosis lead not only to pathologies of the gastrointestinal tract, but also increase the risk of developing diseases of the cardiovascular and endocrine systems, and cause disturbances in the psycho-emotional state.

   To restore, correct and maintain the gut microbiota, probiotic preparations are recommended. In connection with the obvious relevance of the use of probiotics, this review aimed to describe the history of the emergence of the first probiotic products, current trends in the development of the concept of functional foods enriched with probiotics, as well as the prospects for developing probiotic preparations in the Russian Federation and abroad.

   This article presents an analysis of the market for probiotic preparations and dietary supplements, as well as functional food products that are produced in the Siberian Federal District. For an objective assessment of the development of the market for probiotic products, a generalization of analytical data from marketing services that monitor the movement of medicines in pharmacy chains and analyze consumer reviews was carried out.
Some pharmacogenetic aspects of the ABCB1 gene in lopinavir / ritonavir concentration variability in children with HIV infection: A pilot study
Authors: Sambyalova A. Yu. , Bairova T. A. , Manaenkova T. L. , Belskikh A. V. , Belyaeva E. V. , Ershova O. A. , Kumratov D. V. , Paramonov A. I. , Plotnikova Yu. K. , Kolomeets L. V. , Rychkova L. V.
Published: December 2022

Polymorphic variants of the multidrug resistance gene (ABCB1 or MDR1) are associated with changes in the absorption and transport of drugs in the body. One of the substrates of the ABCB1 transporter is an antiretroviral drug from the class of protease inhibitors, lopinavir.   The aim. To research the effect of polymorphic variants C1236T and C3435T in the ABCB1 gene on the plasma concentration of lopinavir / ritonavir in children and adolescents living with HIV infection.   Methods. The genotypes of polymorphic variants of the ABCB1 gene were identified in 136 HIV infected children and adolescents; median age – 10 [7–12] years. The plasma concentration of lopinavir / ritonavir was measured from blood taken during the next scheduled appointment as part of dispensary observation at the Irkutsk Regional AIDS Centre using high performance liquid chromatography.   Results. The average duration of lopinavir/ritonavir use as part of an antiretroviral therapy was 55 months. Median viral load in patients was 1 [1–2.03] log 10  copies/ mL; the number of CD4 +  T cells – 38.36 %. The frequency of occurrence of the 3435T and 1236T alleles of the ABCB1 gene was ~50 %. In carriers of the 3435TT genotype, the median lopinavir concentrations 2 and 12 hours after drug intake were 5050.8 [3615.8–5847.7] and 2665.5 [216–4896.3] ng/mL, respectively. In carriers of the 1236TT genotype, median lopinavir concentrations 2 and 12 hours after drug intake were 4913.5 [3355.1–5733.7] and 3290.6 [159.1–4972.5] ng/mL, respectively.   Conclusions. The study did not reveal a significant relationship between the carriage of the C3435T and C1236T genotypes of the ABCB1 gene and the concentrations of lopinavir and ritonavir 2 and 12 hours after drug intake.
ELISPOT assay of the SARS-CoV-2 specific T cells immune response
Authors: Gerasimova V. V. , Kolesnik S. V. , Kudlay D. A. , Golderova A. S.
Published: December 2022

The COVID-19 pandemic has stimulated interest in the development of biotechnology, as well as in the search for new solutions in the diagnostics of immune processes. The response of immunoglobulins A, M and G had a significant role in the assessment of virus-specific immune responses. Later, it was understood that for a comprehensive assessment of adaptive immunity processes, it is reasonable to study its cellular component. One of the most affordable methods for assessing T cell immunity, which has proven itself in the diagnosis of other infectious diseases, such as latent tuberculosis infection, is IGRA ELISPOT.The aim of the study. To determine SARS-СoV-2 specific immune response of T lymphocytes in vitro in the peripheral blood of volunteers from various groups using IGRA ELISPOT method. We evaluated the applicability of the method to assess T cell immune response to infection and vaccination. In addition, we determined the duration of the maintenance period of the SARS-CoV-2 specific T cells immune response induced by vaccination.Materials and methods. The study was carried out on venous blood samples of volunteers from three groups: 1) hospital patients with COVID-19; 2) COVID-19 convalescents; 3) vaccinated against COVID-19. The T cell immune response was assessed using the TigraTest® SARS-CoV-2 test system, which determines in vitro the number of T cells secreting interferon-gamma in response to stimulation with SARS-СoV-2 peptides in two antigens panels: 1) peptides of the spike protein (S); 2) peptides of N, M, Orf3a and Orf7a proteins.Conclusion. The IGRA ELISPOT assay is a specific and sensitive tool in the assessment of T cell immunity to the SARS-CoV-2 virus. The method makes it possible to assess SARS-CoV-2 specific T cell responses induced both by natural encounter with the pathogen and by vaccination. It is advisable to use the method in routine practice for comprehensive assessment of immunity to SARS-CoV-2.
Design of organyl phosphate-based pro-drugs: comparative analysis of the antibiotic action of alkyl protecting groups with different degree of fluorination
Authors: Pristavka А. А. , Mikhailenko V. L. , Vyatchina O. F. , Yurinova G. V. , Verkhoturova S. I. , Apartsin K. A. , Salovarova V. P.
Published: December 2022

Background. Molecular structures combining a phosphorus-containing counterpart and non-polar radicals are employed in design of pro-drugs as structural and functional groups necessary for transportation of drugs through cellular barriers. It is assumed that the carrier itself does not exhibit biological activity. However, the “organic phosphate – alkyl radical” complex may possess its own metabolic and pharmacological properties even in the absence of a drug moiety.The aim. To study the effect of fluorinated alkyl phosphates on the growth of bacterial test cultures in an agar medium and to identify conjugated metabolic markers using UV/visible spectroscopy.Materials and methods. The effect of six organyl phosphates on the growth of five types of bacteria under aerobic conditions was evaluated by the method of wells in an agar medium. For solutions containing cell metabolites of Pseudomonas aeruginosa, the absorption spectra were recorded at 250–280 nm. The principal component analysis (PCA) was used for multivariate comparative analysis of the spectra. Results. The studied organyl phosphates bearing the ethyl and propyl radicals are potential temporary carriers of the drug moiety, since they are capable of penetrating through cellular barriers. However, the fluorinated compounds exhibit bactericidal properties, the degree of which depends on the arrangement of fluorine atoms in the radical. The most active compounds are those exhaustively halogenated at the terminal carbon atom of the ethyl radical (-СН2-СF3), while non-fluorinated organyl phosphate is the least active. UV/visible spectra of P. aeruginosa cultivation products, according to PCA data, contain patterns reflecting the metabolic effects mediated by these structural features of the radicals.Conclusion. In terms of practical application of the studied compounds, the activity of a proantibiotic based on organyl phosphate with a non-fluorinated ethyl(propyl) radical will be determined only by the specificity of the drug moiety. Exactly the same molecule, but exhaustively fluorinated at the terminal carbon atom of the alkyl radical, is likely to be characterized by lower specificity and higher activity under the additive (or synergistic) action of metabolically active groups.
Possible use of corneal lenticule in surgery of corneal diseases (literature review)
Authors: Boiko E. V. , Titov A. V. , Masian J. I. , Mirsaitova D. R.
Published: December 2022

In this review, we analyzed the domestic and foreign literature on the use of corneal lenticula obtained by keratorefractive surgery using the SMILE technology (SMall Incision Lenticula Extraction). Research is being actively carried out on the use of a lenticular tissue for refractive purposes: for the correction of hyperopia (LIKE – Lenticular Intrastromal Keratoplasty), for the correction of presbyopia (PEARL – PrEsbyopic Allogenic Refractive Lenticule). A significant amount of works are devoted to the use of lenticular tissue for the treatment of keratectasias of various origins. For example, a number of authors for the treatment of keratoconus suggest implantation of a lenticule into the recipient’s corneal pocket formed by a femtolaser (SLAK – Stromal lenticule addition keratoplasty). Clinical cases of combined treatment are described: implantation of a lenticule and corneal intrastromal segments for the treatment of corneal pellucid degeneration. A large number of works are devoted to the use of lenticules for tectonic coverage of ulcerative defects, marginal thinning in Mooren’s ulcer. Several clinical cases of the use of a corneal lenticule to cover a deep corneal defect in recurrent pterygium are described. This review also included articles on the storage and decellularization of corneal lenticules. The analyzed articles show a wide area of application of the corneal lenticule; however, more research is required in each of the areas of application, and it is also necessary to solve the problem of procurement and storage of lenticular tissue.
Providing specialized care to patients with a rupture of the distal tendon of the biceps brachii: diagnosis and treatment algorithm
Authors: Medvedchikov A. E. , Anastasieva E. A. , Korytkin A. A. , Kirilova I. A.
Published: December 2022

Biceps brachii distal tendon injury is rare, 2.55–5.35 per 100,000. This nosological form did not have a gender modality and was previously found mainly in middle-aged men (46.3 y.o.). By 2022, this injury “rejuvenated” and began to occur more often, covering the categories of juniors and young athletes, whose professional activities have expanded significantly with the advent of new power disciplines, contact sports and popularization of bodybuilding. The authors note the negative impact of smoking and the use of anabolic steroids, statins and obesity on the incidence of these lesions. The maximum supination force in this type of injury is reduced by an average of 40 %, and the maximum flexion force is reduced by an average of 20 %. Considering the significance of functional disorders not only of the elbow joint, but also of motor patterns of the entire upper limb girdle for professional athletes, sports-organized people and people involved in the physical aspects of labor, surgical treatment is recommended. Nonsurgical treatment can be aimed at suppressing edema and inflammation, limiting early movements in the elbow joint and increasing secondary muscle tension, and it is suitable for patients with low functional demand, poor compliance and high risks of both surgical treatment and anesthesia care. That is, the choice of treatment tactics is still based, in addition to anatomical changes and on the “subjective” patient data, his/her needs for physical activity and requires an algorithmic approach in order to avoid both known complications and confidently predict a positive result during the prehospital period. Based on ten years of clinical and practical experience adjusted by widely available scientific periodicals, we have developed a scheme that is understandable to every specialist in the field of traumatology, orthopedics or sports medicine, and is applicable regardless of the medical institution level. For the first time, this scheme was published in this work.
Staged treatment of abdominal sepsis in a puerpera with COVID-19 and pancreatonecrosis after cesarean section: case report
Authors: Grigoryev E. G. , Sereda L. V. , Ayushinova N. I.
Published: December 2022

The aim of the study. Description of the medical history and discussion of treatment tactics in a puerperal woman after a caesarean section against the background of pancreatic necrosis, panmetritis, abdominal sepsis, COVID-19.Material and methods. A 30-year-old pregnant woman (30–31 weeks) was hospitalized in a perinatal center 5 days after the onset of girdle pain in the abdomen and uncontrollable vomiting, which did not bring relief. She had a history of caesarean sections 10 and 5 years ago. Sterile pancreatic necrosis was diagnosed. Successful caesarean section was performed. During the revision of the abdominal cavity, multiple plaques of fatty necrosis, omentobursitis were found in the upper abdomen. The treatment included pancreatic abdominization, cholecystostomy, abdominal drainage. Clinical roentgenologic examination and PCR-test verified COVID-19.Infected pancreatonecrosis developed, complicated with necrotic omentitis, abscess of the omental bursa (Enterococcus faccilis 107 CFU, Acinobacter baumani 106 CFU), abdominal sepsis, successfully treated. During vaginal examination, hemorrhagic discharge appeared (Klebsiella pneumoniae 105 CFU, Pseudomonas aeruginosa 105 CFU). Extirpation of the uterus revealed the defect of the anterior wall, thrombosis of the uterine arteries and veins, peripheral vessels. The patient recovered. The body build index was 26.03 kg/m2 at admission, 18.22 kg/m2 – at discharge, 23.61 kg/ m2 – 3 months later.Conclusion. 1. During the COVID-19 pandemic, pregnant women are often targeted by SARS-CoV-2. Prevention, diagnosis and treatment of coronavirus infection should be carried out according to the recommendations approved by the authorized health organ. 2. In the presented case report, the pathogenesis of complicated sterile pancreatonecrosis, cesarean section, abdominal sepsis were significantly influenced by changes due to organ ischemia in the result of peripheral vessels thrombosis. 3. The severity of the patient’s condition was certainly determined by the miscellaneous microbial profile – association of four agents of aggressive in-hospital infection in high concentration.
Kinerja Semen Portland Komposit Sebagai Stabilisator Subgrade dan Pengaruhnya Terhadap Nilai Kuat Tekan Bebas
Authors: Fathonah Woelandari , Mina Enden , Kusuma Rama Indera , Damari Dicky
Published: December 2022

Tanah berfungsi sebagai penopang pondasi bangunan di atasnya dalam berbagai macam pekerjaan teknik sipil. Studi kasus pada penelitian ini adala Desa Cibingbin Kecamatan Cibaliung Kabupaten Pandeglang, karena secara visual jalan rusak dan bergelombang, berdasarkan uji DCP tanah memiliki nilai CBR lapangan sebesar 2,667%. Menurut Ditjen Bina Marga−Kemen PUPR tahun 2017, nilai CBR untuk tanah dasar di bawah 6% perlu distabilkan. Pada penelitian ini dilakukan stabilisasi tanah menggunakan semen Portland dengan pengujian laboratorium yaitu uji fisik tanah dan uji kuat tekan bebas. Variasi semen portland yang digunakan yaitu 0 %, 3%, 5% dan 7% dengan lama pemeraman 0 hari , 7 hari dan 28 hari. Nilai qu tanah asli pada pemeraman 0 hari adalah 2.007 kg/cm2, 3%, 5% dan 7% nilai qu meningkat masing-masing menjadi 3.348 kg/cm2, 4.635 kg/cm2, 5.377 kg/cm2, dan nilai qu untuk pemeraman 7 hari adalah 2.119 kg/cm2, 4.718 kg/cm2. 5.764 kg/cm2, 6.276 kg/cm2. Nilai qu maksimum diperoleh pada variasi semen portland 7% dengan lama pemeraman 7 hari. Nilai indek plastisitas tanah asli adalah 42,86% dan pada variasi semen portland 7% dengan lama pemeraman 7 hari mengalami penurunan sebesar 24.62% dengan kategori plastisitas tinggi, sehingga perlu dilakukan penelitian lebih lanjut agar diperoleh nilai indeks plastisitas yang sesuai dengan kriteria untuk subgrade jalan.
Agamennone classico e contemporaneo
Authors: Citti Francesco , Iannucci Alessandro , Ziosi Antonio
Published: December 2022

Like its predecessors, Edipo classico e contemporaneo, edited by F. Citti and A. Iannucci
(Hildesheim; Zürich; New York, 2012) and Troiane classiche e contemporanee, edited by
F. Citti, A. Iannucci, A. Ziosi (Hildesheim; Zürich; New York, 2017) this new volume seeks
to stage a dialogue between a Greek play and a Latin one, Aeschylus’s Agamemnon and
its Latin rewriting by Seneca. But at the same time, this intertextual dialogue becomes,
in turn, a fundamental hypotext for further and varied ‘rewritings’ of the myth and
the story of Agamemnon, in plays, opera librettos, novels, films, paintings and reenactments,
from the Renaissance to the present day, as many papers in this book
show, with new and original insights in the ever-growing realm of Reception studies.
Tsunami Mitigation Strategy at Watu Ulo Beach Based on Numerical Modeling Using Delft3D-Flow
Authors: Sofiana Risqi , Wiyono Retno Utami Agung , Nurtjahjaningtyas Indra
Published: December 2022

The coastal area of Watu Ulo Beach in Jember has great resource potential but also the potential for major disasters, such as a tsunami. Tsunamis can cause casualties and destroy buildings. Thus, it is important to assess the possibility of future tsunami disasters. This study aims to simulate a tsunami at Watu Ulo Beach using Delft3D-Flow to analyze the possibility of affected areas. The tsunami modeling is based on two simulations, namely Scenario 1 as model validation using the characteristics of the 1994 Banyuwangi earthquake. Model validation calculation uses the MAPE method <10%. Scenario 2, modeling the southern Java megathrust earthquake, was analyzed to obtain the time and wave height as well as tsunami run-up and inundation, visualizing the area affected by Watu Ulo Beach. The simulation results show that the tsunami wave height at Watu Ulo Beach reached 12.57 m with a travel time of 29 minutes. The run-up elevation was 9.21 m, and the inundation distance was 2.38 km from the Watu Ulo coastline, indicating that the tsunami caused substantial damage. As an area affected by the tsunami, Sumberejo Village has an inundation area of 634.68 ha, and Sabrang Village has an area of 250.03 ha. The temporary evacuation location for Watu Ulo Beach is set at Tanjung Papuma Street via the shortest route of 0.57 km from the assembly point. Based on the results of this study can be used as a reference for determining temporary evacuation routes and locations for tsunami disaster mitigation in coastal areas.
Parametric Study of Large Settlement Due to Prefabricated Vertical Drain with Surcharge Preloading
Authors: Maruf Mokhammad Farid
Published: December 2022

Prefabricated vertical drain (PVD) combined with preloading is one way to deal with soft soil conditions. The predicted settlement becomes the first information in designing the surcharge, PVD configuration and depth, and the time required to complete the consolidation. Prediction of consolidation settlement that using one-dimensional theory considerably underestimated the field settlement along the construction of the surcharge placement stage. This paper intends to evaluate the completed PVD preloading construction project. Inclinometer monitoring data was evaluated to confirm whether the consolidation existed on preferred clay layers. The parametric study evaluated the root cause of the gap between prediction settlement and monitoring data. The root cause analysis continued with a parametric analysis using back calculations. The back analysis involved various Cc, Cs, and pc' that play a significant role in soil settlement. The results show that the conservative value of those parameters simulated separately could not raise the ultimate settlement into inner upper and lower bond results. However, combining those would lead to more accurate predictions that agree with the ultimate settlement. This parametric analysis result also confirms that overconfidence in picking soil parameters could lead to underestimating field settlement. Furthermore, selecting conservative parameters in consolidation settlement should avoid a big gap between prediction and field ones and put construction safe. It was decisive work to be done for further anticipation during and post-construction.
TÜRKİYE ÖRNEĞİNDE ÇEVRESEL KALİTENİN BELİRLEYİCİLERİ: LASSO YAKLAŞIMI
Authors: GÖV Abdullah , KAPKARA KAYA Sevcan
Published: December 2022

Sürdürülebilir kalkınma, son zamanlarda hem bilim adamları hem de politika yapıcılar tarafından büyük ilgi görmektedir. Sürdürülebilir kalkınmanın en önemli temel bileşenlerinden biri de çevresel kalitedir. Bu çalışmanın amacı Türkiye’de çevresel kalitenin bozulmasına yol açan faktörleri tespit etmek ve Türkiye’nin çevre kirliliği durumuna dikkat çekmektir. Çalışmada 1998-2019 dönemi verileri kullanılarak, ilgili alan literatüründe pek sık kullanılmamış yeni bir tahmin yöntemi olan En küçük Mutlak Küçültme ve Seçim Operatörü (LASSO) metodu kullanılmıştır. Elde edilen analiz sonuçları, Türkiye’de doğrudan yabancı yatırımlar, ekonomik büyüme, motorlu taşıt sayısı, finansal gelişme, enerji tüketimi, çevre vergisi ve teknoloji ihracatı değişkenlerinin CO2 emisyonlarının belirleyicileri olduğunu göstermiştir.
Die KonfliktHotline des Bundesverbandes MEDIATION e. V.
Authors: Fischer Steffen , Heider Wiebke , Wellmann-Hufnagel Edith
Published: December 2022

Seit Ostern 2020 gibt es die Konflikt-Hotline. Damals wurde sie sehr schnell ins Leben gerufen, um ein niedrigschwelliges Angebot für Menschen mit akuten Problemen aufgrund häuslicher Quarantäne zu bieten. Mittlerweile hat sich die Coronalage entspannt. Die Konflikt-Hotline ist aber nach wie vor gefragt, da äußere Umstände wie der Ukrainekrieg und seine Folgen das Konfliktpotenzial weiter anfachen. Waren es zu Beginn viele innerfamiliäre Konflikte, wird heute verstärkt um Unterstützung bei der Mediator:innensuche gebeten.
Die Antwort ist immer: #Mediation!
Authors: Brinkmann Mara
Published: December 2022

Vor meiner Mediationsausbildung arbeitete ich als Marketingmanagerin und entwickelte Konzepte, die Produkte am Markt erfolgreich machen. Als ich mich entschied, diesen Beruf aufzugeben, um als selbstständige Mediatorin zu arbeiten, glaubte mein Umfeld, dass mir die Selbstvermarktung leichtfallen müsste: »Ob du nun Linsenchips oder dich selbst vermarktest – wo ist da der Unterschied?« Überall – kann ich nach einem Jahr Erfahrung sagen.
Blinde Flecken im Marketing von Mediator*innen
Authors: Berger Melanie
Published: December 2022

Kaum einer anderen Disziplin ist es so wie der Mediation gelungen, ihre Wirksamkeit und ihren Sinn so lange so konsequent vor der Öffentlichkeit zu verbergen. Und das, obwohl ihr Bekanntheitsgrad beachtlich ist. Selbst die gesetzliche Verankerung auf EU-Ebene brachte bislang kein nennenswertes Ergebnis. Das bedeutet nicht, dass Mediation schlecht ist, sondern eher: Wir Mediator*innen haben im Marketing bisher versagt. Kratzen wir die Kurve noch oder ist es zu spät?
»Normales« Marketing und Marketing von Mediator*innen
Authors: Trainer Imke , Hausmann Rüdiger
Published: December 2022

Marketing von Mediator*innen funktioniert anders. Nicht gänzlich anders, aber anders genug. Gleichzeitig verbreiten sich aktuell einige ermutigende Ansätze im Online-Marketing, die gut zur Haltung der Mediation passen. Was sind die fünf zentralen Unterschiede zwischen »normalem« und Marketing für Mediator*innen? Und wie machen wir Mediator*innen gerade in unserem Marketing die Haltung und das Versprechen der Mediation erfahrbar?
Possibility of creating a reference population of Ayrshire cattle
Authors: Petrova A. , Vasileva E.
Published: December 2022

Purpose: the goal is to study the abundance, distribution area and genetic similarity of regional populations of the Ayrshire breed of the Russian Federation for the possibility of forming a reference population and conducting a genomic assessment using modern methods for small populations of cattle.

Materials and methods. The material was articles and presentations of domestic and foreign researchers, statistical data on the breeding and bovine livestock of the Ayrshire breed of dairy cattle in yearbooks, bulletins and catalogs for evaluating bulls of enterprises in Russia. Studied and analyzed electronic resources.

Results. To introduce genomic selection (GS) for Ayrshire cattle of Russia, it is necessary to form a reference population, which will be used to link molecular markers (SNPs) with the breeding value of animals evaluated using the BLUP method. At the same time, with an increase in the accuracy of the assessment of animals and the accumulation of livestock, the reliability of the genomic assessment increases. Accounting for the productive traits of the descendants and daughters of bulls is necessary to replenish and update the reference population in order to obtain a more accurate genomic assessment in the future. With the introduction of GS, the genetic progress of the population will accelerate, the generation interval and economic costs for the producer will decrease. The accuracy of genomic prediction increases significantly and will exceed the prediction for parental individuals.

Conclusion. As a result of the analysis, it was found that in the coming years it is possible to form a reference population for the genomic assessment of Ayrshire cattle. The reference population will allow as soon as possible to start the process of introducing GS to breed highly productive domestic animals, since today the Ayrshire cattle of Russia cannot compete not only at the world level with the leaders of animal husbandry, but also within the country with imported genetics.
Genetic diversity of some mitochondrial DNA genes in a mixed population of sockeye salmon (Oncorhynchus nerka) of the Ola River (northern coast of the Sea of Okhotsk)
Authors: Pustovoyt S. , Shvets P.
Published: December 2022

Purpose: Analysis of the first stage of monitoring the genetic variety of two genes of MTDNK of the mixed population of Nerca river. Ola.

Materials and methods. Separate nonsense were caught during the spawning stroke at the mouth of the Ola river in late June - early July 2014 (13 individuals), 2020 (9 individuals) and 2021 (9 individuals). The material (muscles) was stored in a frozen state. DNA allocation and determination of nucleotide sequences of these genes are made in PJSC Sentol, Moscow. The sequences of the nucleotides of the studied MTDNK genes are leveled using the Clustal W program included in the MEGA version of version 11. The specified program was used to assess the value of nucleotide differences (R-disters) between individuals for the design of dendrograms. The clustering method for constructing dendrograms is unnecessary in pairs-group (UPGMA). The quantitative parameters of haplotypic and nucleotide diversity were found using the program DNASP, V. 5.

Results. Nucleotide diversity of 31 sockeye salmon from three samples (2014, 2020 and 2021) from the population of the Ola River for the cytochrome oxidase gene of mtDNA subunit 1 (CO I) was the value π=0.00505±0.000080, haplotypic diversity Hd = 0.708±0.0042.These indicators for 18 individuals from two samples (2020 and 2021) for the cytochrome b gene (cyt b) mt DNA π = 0.00184± 0.000075 and Hd = 0.699±0.0158.Significant differences in the nucleotide sets of both genes between samples of different years were noted. It is possible that the detected interannual differences in the nucleotide sets of samples of sockeye salmon producers are associated with the influence of fish-breeding activities conducted by employees.
Examining Algebraic Habits of the Mind through a Problem Solving: Elementary School Example
Authors: Aslan Bilge Yilmaz , Özmusul Begüm
Published: December 2022

In this study, it is aimed to determine the algebraic thinking habits of two eighth grade school students through the answers they gave in the process of solving mathematical problems. The algebraic habits of mind (ZCA) theoretical framework developed by Driscoll (1999) was used to reveal these thinking habits. The research design of this study is a case study and the participants consist of two eighth grade students. The data were analyzed using Driscoll (1999)'s ZCA framework, which is algebraic habits of mind. Descriptive analysis was used in the analysis of the data. When we look at the findings obtained from the research; It is seen that both students can do describing a rule and justifying a rule in the solutions of the problems. In addition, it is seen that computational shortcuts, equivalent expressions and symbolic expressions come to the fore in the solutions of students' problems. On the other hand, the habit of undoing in solving problems was not encountered very rarely in both students. In the light of the findings obtained, the reasons for the existing and non-existent algebraic habits of mind are discussed. As a result of this discussion, it is thought that it is effective to include guide questions to create and develop algebraic thinking habits in students in classroom teaching practices of teachers.
Barometers behaving badly II: A critical evaluation of Cpx-only and Cpx-Liq thermobarometry in variably-hydrous arc magmas
Authors: Wieser Penny , Kent Adam , Till Christy
Published: December 2022

The chemistry of erupted clinopyroxene crystals (±equilibrium liquids) have been widely used to deduce the pressures and temperatures of magma storage in volcanic arcs. However, the large number of different equations parametrizing the relationship between mineral and melt compositions and intensive variables such as pressure and temperature yield vastly different results, with implications for our interpretation of magma storage conditions. We use a new test dataset comprised of the average Cpx-Liq composition from N=543 variably-hydrous experiments at crustal conditions (1 bar to 17 kbar) to assess the performance of different thermobarometers, and identify the most accurate and precise expressions for application to subduction zone magmas. First, we assess different equilibrium tests, finding that comparing the measured and predicted EnFs and KD (using Fet in both phases) are the most useful tests in arc magmas, while CaTs, CaTi and Jd tests have limited utility. We then apply further quality filters based on cation sums (3.95-4.05), number of analyses (N>5), and the presence of reported H2O data in the quenched experimental glass (hereafter ‘liquid’) to obtain a filtered dataset (N=214). We use this filtered dataset to compare calculated versus experimental pressures and temperatures for different combinations of thermobarometers. A number of Cpx-Liq thermometers perform very well when liquid H2O contents are known, although the Cpx composition contributes relatively little to the calculated temperature. Most Cpx-only thermometers perform very badly, greatly overestimating temperatures for hydrous experiments. These two observations indicate that the Cpx chemistry alone holds very little temperature information in hydrous systems. Cpx-Liq and Cpx-only barometers show similar performance to one another, with most expressions yielding RMSEs of 2-3.5 kbar. We also assess the sensitivity of different equations to melt H2O contents, which are poorly constrained in many natural systems. Overall, this work demonstrates Cpx-based barometry on individual Cpx only provides sufficient resolution to distinguish broad storage regions (e.g., upper, mid, lower crust). However, after significant amounts of averaging of Cpx compositions from experiments reported at similar pressures, RMSEs can reduce to ~1.3-1.9 kbar for the best-behaving expressions. We hope our findings motivate the substantial amount of experimental and analytical work that is required to obtain precise and accurate estimates of magma storage depths from Cpx±Liq equilibrium in volcanic arcs.
Intuitions about Mathematical Beauty: A Case Study in the Aesthetic Experience of Ideas
Authors: Johnson Samuel Gregory Blane , Steinerberger Stefan
Published: December 2022

Can an idea be beautiful? Mathematicians often describe arguments as “beautiful” or “dull,” and famous scientists have claimed that mathematical beauty is a guide toward the truth. Do laypeople, like mathematicians and scientists, experience mathematics aesthetically? Three studies suggest that they do. When people rated the similarity of simple mathematical arguments to landscape paintings (Study 1) or pieces of classical piano music (Study 2), their similarity rankings were internally consistent across participants. Moreover, when participants rated beauty and various other potentially aesthetic dimensions for artworks and mathematical arguments, they relied mainly on the same three dimensions for judging beauty—elegance, profundity, and clarity (Study 3). These aesthetic judgments, made separately for artworks and arguments, could be used to predict similarity judgments out-of- sample. These studies also suggest a role for expertise in sharpening aesthetic intuitions about mathematics. We argue that these results shed light on broader issues in how and why humans have aesthetic experiences of abstract ideas.
Implementación de un Software para el Diseño de Anclajes en Vigas y Columnas de Estructuras Metálicas
Authors: Suquillo-Ronquillo Betzabeth , Cabrera-Álvarez Evelyn , Chacón-Sánchez Juan , Mayacela-Rojas Margarita
Published: December 2022

Dentro del sistema constructivo que forman parte de las conexiones en estructuras metálicas, se encuentran elementos estructurales que aseguran la continuidad del edificio y transmiten fuerzas de un miembro a otro, los cuales se denominan placas base para columnas y placas de soporte para vigas. El análisis de estos elementos consiste en un proceso sistemático y matemático bastante extenso, lo que ocasiona que el tiempo empleado para el diseño sea considerable lo cual puede generar errores matemáticos, pudiendo generar elementos sobredimensionados, lo cual ocasionaría la utilización de recursos económicos innecesarios o a su vez generaría elementos sub-dimensionados que indicaría una resistencia menor a la requerida provocando grandes problemas en el comportamiento de la estructura. En el presente artículo se muestra la implementación de un software libre y de fácil manejo para el diseño de anclajes de columnas y vigas metálicas (ANCHOR DESIGN) de acuerdo con lineamientos establecidos por la norma ANSI/AISC 360-16. Los resultados obtenidos fueron validados y comparados manualmente y con otras investigaciones reflejando bajos porcentajes de diferencia lo cual asegura la fiabilidad del diseño y asegura el vínculo entre la fundación y la superestructura.
MANEJO DE ANTIBIÓTICOS EN INFECCIONES INTRAABDOMINALES BAJO LA PERSPECTIVA DE LA RESISTENCIA A LOS ANTIMICROBIANOS EN EL SERVICIO DE CIRUGIA DEL HOSPITAL GENERAL DE LATACUNGA
Authors: Chicaiza Tayupanta Jesús Onorato , Chicaiza Quishpe Diana Cristina
Published: December 2022

El desarrollo de la resitencia a los antimicrobianos en las infecciones intraabdominales requiere de un especial cuidado en la selección del esquema antibiótico para tartarlas. Objetivo: Nos proponemos revisar los esquemas de antibióticos primario y secudario utilizados en un servicio de cirugía bajo la perspectiva de la resistencia a los antimicrobianos. Materiales y metodos: se realizaron 165 cultivos en igual número de pacientes intervenidos quirurgicamente por infecciones intraabdominales en un Hospital de II nivel de atención de los cuales 134 desarrollaron especies de enterobacterias, 47 sensibles a los antimicrobianos y 87 resistentes en algun grado a antibioticos disponibles. Resultados: El esquema antibiótico primario incluyó los siguientes antibióticos: ceftriaxona/metronidazol 75,37%, Ampicilina/sulbactam 17,91%, ceftriaxona (sola), 2,99%, ciprofloxacina/metronidazol, 2,24% y ampicilina/metronidazol 1,49%. Las enterobacterias identificadas fueron en orden de frecuencia: fue E. coli (79%),  K. neumonía (10%), P. aeruginosa (5%), P. vulgaris (4%), otras enterobacterias menos frecuentes fueron, C. freundi y E. cloacale.(2%), K. oxitoca, hafnia A, K. ozonea y S. marcenses menos de 2%. La resistencia de las Enterobactericeas:  un 89,76%  a la Ampicilina, 66,14% a la cefalotina y 66,20% a las sulfas. En cuanto a la E. coli los procentajes de resistencia fueron los siguientes: Ampicilina 89,62%,   Cefalotina 62,26%;  Mayor sensibilidad a: Aminoglucosidos 85,85%, Ciprofloxacina 66,04%, con porcentajes de sensibilidad  bajos a las Cefalosporinas de tercera generación (63 a 67%). Al imipenem se mantine altos niveles de sensibilidad (97,71% y 99,6%). Se cambió en un 40%  de casos a un nuevo esquema antibiótico que representó los siguientes porcentajes: Ceftriaxona/metronidazol en 20 pacientes (35,71%), seguido al esquema Piperacilina/tazobactam en 10 pacientes (17,86%), a Imipenem en 7 pacientes (12,5%) y en menores porcentajes a varios antimicrobianos identificados como efectivos en el tratamiento por los niveles de sensibilidad por las enterobacterias identificadas. La estancia hopitalaria estuvo en un promedio de 12,63 dias, las complicaciones se presentaron en 34% de los pacientes y la mortalidad global en 15,67%. Conclusiones:en hospitales de II nivel en el Ecuador  el esquema antimicrobiano primario puede ser la combinación de ceftriaxona/meronidazol aunque en casos seleccionados podría asociarse un aminoglucosido/metronidazol. Es conveniente reservar esquemas antibióticos con carbapenémicos (imepenem) para casos con resistencia a los antimicrobianos del tipo PDR.
Phytochemical Screening, Evaluation of Antioxidant Activity, Total Phenolic and Flavonoid Content of Selected Nepalese Medicinal Plants
Authors: Shrestha Deepak Kumar
Published: December 2022

This research work aimed to analyze the phytochemicals, total phenolic, flavonoid contents, and antioxidant properties of four selected medicinal plants of Gulmi and Rupandehi districts using in vitro studies. They were Dioscorea bulbifera from Gulmi, the other three Aegle marmelos, Nyctanthes arbortristis, Urtica dioica from Rupandehi. Methanolic extract of these plants was analyzed. The DPPH radical scavenging assay was used to measure the antioxidant activity, the Folin-Ciocalteu method to measure total phenolic content, and the aluminum chloride colorimetric method to measure total flavonoid content. Results revealed that plant extract contained phytochemicals such as flavonoids, alkaloids, polyphenols, terpenoids, saponins, quinonnes, etc. The Dioscorea bulbifera showed the highest % of radical scavenging activity up to 82.31±2.43µg/ml with an IC50 value of 51.102±6.424µg/ml followed by Nyctanthes arbortristis and the lowest in Urtica dioica with IC50 value 70.716±1.55 µg/ml, 179.103±3.580 respectively. Dioscorea bulbifera revealed the highest TPC and TFC of 136.667±5.08 mgGAE/g and 33.41±1.720 mgQE/g followed by Nyctanthes arbortristis and lowest in Urtica dioica. These parameters were analyzed from the period of 15 September 2021 to 20 October, 2021.
Teachers’ Perception of the Students’ Readiness for Self- regulated Learning during the COVID-19 Pandemic
Authors: Nepal Karuna , KC Saban Kumar
Published: December 2022

COVID - 19 pandemic has detrimental impacts on the educational sector along with many other areas of human life. Virtual learning, though not a new topic, has occupied huge space in current pedagogical discourse. However, it has been criticized for exacerbating inequalities between well-resourced and under-resourced people, institutions and geographical location. In this scenario, we propose self-regulated learning as a viable solution to avert the learning gap during possible crises in the future. In this article, we explored how empowered are the learners for carrying out self-regulated learning. This qualitative study in which data were elicited through three focus group discussions with 15 ELT teachers revealed that the students having a lack of sufficient knowledge and skill for continuing learning in the absence of a teacher, indicated to the possible discontinuation of learning during the school closure circumstanced by COVID- 19 pandemic.
PERBAIKAN KINERJA GUDANG MELALUI PENATAAN ULANG TATA LETAK GUDANG SUKU CADANG MENGGUNAKAN METODE CLASS BASED STORAGE DI PT DN SEMARANG
Authors: Rauf Muhammad , Radyanto Mohammad Riza
Published: December 2022

PT.DN adalah produsen furnitur berorientasi ekspor yang sedang melakukan tindakan perbaikan kinerja gudang,yaitu penataan ulang tata letak gudang suku cadang karena menimbulkan permasalahan yaitu penempatan suku cadang tidak sesuai tempatnya mengakibatkan keterlambatan pengiriman ke bagian produksi,tidak ada label nama barang di rak sehingga pengunaannya tidak beraturan. Penelitian ini bertujuan untuk mencari solusi perbaikan kinerja gudang dengan menggunakan Metode Class Based Storage (CBS) yang diusulkan kepada perusahaan agar kinerjanya meningkat. Dari hasil menerapan sistem tersebut diperoleh usulan dari jumlah rak awal sebanyak 11 buah menjadi 8 rak sehingga dari penyimpanan ruang tersisa dapat dimanfaatkan tempat barang masuk. Pada gambar tata letak gudang usulan terdapat penurunan total jarak tempuh dari jarak tempuh pada gudang awal sejauh 767,368 m lebih pendek menjadi 615,761 m pada jarak tempuh gudang usulan menjadi lebih efisien.Dari penelitian ini disimpulkan bahwa penerapan metode CBS dapat meminimalisasi permasalahan di perusahaan dan meningkatkan produktivitas GudangKata Kunci: kinerja gudang,Class Based Storage, tata letak gudang
Pelatihan Penyusunan Dokumen Perjanjian bagi Industri Rumah Tangga di Desa Paremono Kecamatan Mungkid Kabupaten Magelang
Authors: Dakum Dakum , Dewi Dyah Adriantini Sintha , Rahmanto Fendi , Paripurno Yudho , Prianto Nurdhin , Nurcholis Nurcholis , Murti Ahimsa Wisnu
Published: December 2022

Sebagian besar penduduk Dusun Mertan, Desa Paremono, Mungkid, Kabupaten Magelang berprofesi sebagai pelaku industri olahan makanan ringan. Industri makanan ringan tersebut memiliki potensi untuk dikembangkan. Namun demikian, legalitas usaha dan hubungan dengan pihak ketiga menjadi sebuah kendala. Kebanyakan industri tersebut tidak memiliki perjanjian tertulis dengan supplier terkait dengan perolehan bahan baku sehingga seringkali ditipu dan mengakibatkan kerugian bagi pelaku usaha. Kegiatan pengabdian ini bertujuan agar mitra dapat membuat dokumen hukum perjanjian usaha, mengurus legalitas ijin usaha, dan meningkatkan pemasaran produk yang dihasilkan. Metode yang digunakan adalah penyuluhan dan pendampinan kepada mitra secara langsung di lapangan. Langkah-langkah yang dilakukan yakni persiapan pengabdian, pelaksanaan pengabdian, dan penyajian hasil pengabdian. Hasil temuan kegiatan pengabdian ini mitra mampu memahami terkait tata cara membuat dokumen hukum perjanjian usaha, mengurus legalitas ijin usaha, dan meningkatkan pemasaran produk yang dihasilkan secara baik. Kegiatan ini sangat penting dilakukan agar dapat membantu mitra dalam membuat dokumen hukum perjanjian usaha, mengurus legalitas ijin usaha, dan meningkatkan pemasaran produk.
Perlindungan Hukum Bagi Anak Tentang Edukasi Kesehatan Perilaku Hidup Bersih dan Sehat Selama Masa Pandemi Covid 19 di Desa Tiron Kabupaten Madiun
Authors: Sari Rika Maya , R Naylil Mawadda , Andayani Sri , Kristiana Dian , Izziyana Wafda Vivid
Published: December 2022

Pandemi Covid-19 yang saat ini masih terjadi peningkatan kasus, mendorong akademisi memberikan pengabdian masyarakat, berupa upaya perlindungan hukum bagi anak tentang edukasi kesehatan untuk selalu berperilaku hidup bersih dan sehat (PHBS) yang menyesuaikan selama masa pandemi ini. Anak butuh perlindungan hukum atas jaminan kesehatan, anak merupakan salah satu kelompok yang rentan akan terpapar virus Covid-19. Perlindungan hukum melalui Edukasi tentang perilaku hidup bersih dan sehat selama masa pandemi Covid-19 perlu diterapkan, agar anak-anak dapat melakukan pencegahan terpapar Covid-19 secara dini dan mandiri. Untuk mencapai tujuan tersebut adalah melalui pengabdian masyarakat tentang edukasi kesehatan pada orangtua yang memiliki anak usia sekolah bagaimana perilaku hidup bersih dan sehat selama masa pandemi Covid-19. Sasaran pengabdian ini adalah orangtua yang mempunyai anak usia sekolah di lingkungan RT 12 RW 05 Desa Tiron Kecamatan Madiun Kabupaten Madiun. Keberhasilan pengabdian dapat dinilai dari peningkatan pengetahuan orangtua tentang edukasi perlindungan hukum hidup sehat dan perilaku hidup bersih di masa pandemi covid-19.
Pendampingan Hukum di Desa Selokang dalam mengoptimalisasikan Ekonomi Kreatif Berbasis Pariwisata
Authors: Wardani Sheila Kusuma
Published: December 2022

Tujuan utama pelaksanaan kegiatan ini yaitu untuk memberikan pelatihan kepada masayrakat dalam mengoptimalisasi ekonomi kretaif di Desa Selokajang dengan memanfaatkan sektor Pariwisata. Program kerja dilakukan dalam rangka melakukan pemberdayaan UMKM di Desa Selokajang. Pada Masa pandemi Covid-19 diperlukan upaya lebih konkret agar produk UMKM tetap menunjukkan geliatnya. Pelaksanaan pengabdian ini dilakukan selama dua minggu dengan menggunakan media tatap  muka secara langsung.  Pelaksanaan kegiatan pengabdian kali ini dilakukan diantaranya (1) Membantu memasarkan produk UMKM; (2) Membuat design produk; (3) Membantu rebranding dengan pemasaran online di marketplace; (4) Membantu pengolahan produk susu etawa; (5) Membantu marketisasi produk melalui poster. Berdasarkan analisis hasil kegiatan maka dapat disimpulkan bahwa setelah kegiatan dilaksanakan terjadinya peningkatan omset, penyebarluasan akses produk UMKM serta kemampuan melakukan marketisasi produk UMKM menggunakan media sosial dan market place meningkat
Pengabdian Kepada Masyarakat Pemberdayaan Masyarakat dan Pendampingan Belajar Siswa Sekolah Dasar di Masa Pandemi Dusun Brontokan Desa Danurejo Kecamatan Mertoyudan
Authors: Kurniaty Yulia , Choirul Anam M. , Minerva A Wanda , Fitriana Nadia , Mawardani F Bunga , Yanto Suhardi
Published: December 2022

Dusun Brontokan Desa Danurejo Kecamatan Mertoyudan Magelang termasuk wilayah yang terdampak oleh pandemin covid 19. Pandemi Covid 19 dan penyebarannya secara global telah merubah aspek - aspek kehidupan dalam semua dimensi. Situasi penyebaran virus yang cepat maka kegiatan pembelajaran langsung di sekolah harus di hentikan dan di ganti kegiatan pembelajaran daring. Dampak lain dari pandemic covid 19 adalah pada situasi keamanan. Kegiatan ini bertujuan untuk membantu para mitra untuk mendampingi proses belajar siswa dan menambah wawasan mitra tentang pemanfaatan lahan kosong disekitar rumah serta menumbuhkan kesadaran hukum masyarakat dimasa pandemi. Metode yang digunakan adalah sosialisasi dan pendampingan serta penyuluhan kepada mitra secara langsung di lapangan. Langkah-langkah yang dilakukan yakni persiapan pengabdian, pelaksanaan pengabdian, dan penyajian hasil pengabdian. Hasil kegiatan pengabdian ini mitra dapat terbantu dalam mendampingi proses belajar siswa, bertambahnya wawasan tentang pemanfaatan lahan dan kesadaran hukum. Kegiatan ini sangat penting dilakukan mengingat perlu terjaminnya proses belajar siswa serta wawasan tentang lingkungan dan hukum dimasa pandemi.