bluuebunny/crossref_metadata_2025 huggingface dataset:
BMMSC-sEV-derived miR-328a-3p promotes ECM remodeling of damaged urethral sphincters via the Sirt7/TGFβ signaling pathway
Authors: Zhang Hanke , Huang Jiayu , Liu Jiaying , Li Yanhui , Gao Ying
Published: July 2020

Background

Stress urinary incontinence (SUI) is a common and bothersome condition. Invasive surgery will always be considered after conservative treatment fails, but the rates of postoperative complications and long-term recurrence are high. Thus, a new treatment strategy is still needed. In recent years, bone marrow mesenchymal stem cells (BMMSC) have shown great promise for SUI treatment. The therapeutic effects of BMMSC on SUI are achieved mainly by paracrine pathway signaling molecules, such as small extracellular vesicles (sEV). sEV are recognized as essential mediators of cell-to-cell communication. However, the therapeutic effects and detailed mechanisms of BMMSC-derived sEV in SUI remain mostly unexplored.

Methods

The effects of BMMSC-sEV on extracellular matrix (ECM) metabolism were assessed in vitro and in vivo. In a SUI rat model, TGF-β1 signaling was examined with or without BMMSC-sEV stimulation. sEV miRNAs were deeply sequenced, and the most likely miRNAs were evaluated as mediators of the TGF-β1 signaling pathway.

Results

BMMSC-sEV enhanced the synthesis of ECM components, including elastin, collagen I, and collagen III, and improved urethral function. Furthermore, BMMSC-sEV activated TGF-β1 signaling in primary fibroblast cells and in rat urethras. Several differentially expressed miRNAs were identified in the BMMSC-sEV. Bioinformatics analysis and in vitro studies showed that BMMSC-sEV miR-328a-3p can be transferred from BMMSC to fibroblasts and can regulate the Sirt7/TGF-β1 signaling pathway.

Conclusion

BMMSC-sEV promote ECM remodeling of damaged urethral sphincters by transferring miR-328a-3p to regulate the Sirt7/TGF-β1 signaling pathway.
Health-related quality of life, self-reported impairments and activities of daily living in relation to muscle function in post-polio syndrome
Authors: Gocheva Vanya , Hafner Patricia , Orsini Anna-Lena , Schmidt Simone , Schaedelin Sabine , Rueedi Nicole , Rubino-Nacht Daniela , Weber Peter , Fischer Dirk
Published: July 2020

Background

The symptoms of post-polio syndrome (PPS) and its resulting disabilities can affect quality of life and the ability to perform daily activities. No study has comprehensively analysed how various patient-reported outcome measures (PROMs) are associated with objectively assessed physical function in patients with PPS.

Aim

To investigate health-related quality of life (HRQOL), self-reported impairments and activities of daily living during 6 months and evaluate their association with clinical muscle function outcomes in individuals with PPS.

Methods

Twenty-seven patients with PPS were included in the study. At baseline and 6 months, patients were administered PROMs measuring HRQOL (WHOQOL-BREF), self-reported impairments related to PPS (SIPP-RS) and activities of daily living (IBM-FRS). Clinical muscle function outcomes included 6 min walking distance (6MWD) and motor function measure (MFM).

Results

There were no changes in self-reported impairments (25.52 to 24.93, p = 0.40), activities of daily living (33.89 to 33.30, p = 0.20), 6MWD (391.52 to 401.85, p = 0.30) and MFM (83.87 to 85.46, p = 0.14) during 6 months, while the HRQOL psychological health decreased during this period (76.85 to 72.38, p = 0.05). A strong association was found between activities of daily living and clinical muscle function outcomes (6MWD: ß = 0.02, 95% CI: 0.02;0.03, t = 6.88, p < 0.01; MFM: ß = 0.25, 95% CI: 0.17;0.33, t = 6.69, p < 0.01). Self-reported impairments and HRQOL domains were not associated with the clinical muscle outcomes.

Conclusions

Study findings indicate that objectively measured walking and motor abilities do not reflect patient’s perspectives of their HRQOL and impairment due to PPS. More research is needed to assess changes over time and capture clinically meaningful changes in individuals with PPS and to increase the understanding of how the patient’s perspective of disability measured by PROMs is related to objectively measured walking and motor abilities.

Trial registration

ClinicalTrials.gov Identifier (NCT02801071) registered June 15, 2016.
Validity of fibromyalgia survey questionnaire (2016) assessed by telephone interview and cross-cultural adaptation to Brazilian Portuguese language
Authors: Daltrozo Jordana Bernardi , Paupitz Juliane Aline , Neves Fabricio Souza
Published: July 2020

Background

To verify the validity of the 2016-revised Fibromyalgia Survey Questionnaire (FSQ) by telephone interview compared to self-administration and to produce a valid version of FSQ in Brazilian Portuguese language.

Methods

The Brazilian version of FSQ was produced following the recommendations for cross-cultural adaptation. Validity of Brazilian FSQ self-administration was assessed by checking agreement of its results with fibromyalgia diagnosis according the 1990 American College of Rheumatology (ACR) criteria. Reproducibility and validity of FSQ by telephone were assessed by comparing its results with the previous FSQ self-administration.

Results

A Brazilian Portuguese version (FSQ-Brazil) was produced. FSQ-Brazil had good internal consistency (Cronbach’s alpha between 0.73 and 0.94). Agreement between the results obtained by self-administration of FSQ-Brazil and by telephone interview was substantial or almost perfect for almost all questions about pain sites and all questions about other somatic symptoms (Cohen’s kappa higher than 0.6). There were small but significant bias toward higher scores of widespread pain index and fibromyalgia severity scale in the telephone interview compared to self-administration. Fibromyalgia definition by self-administration and telephone interview with FSQ-Brazil both revealed substantial agreement with the diagnosis based on ACR 1990 criteria (Cohen’s kappa 0.62 and 0.65; respectively).

Conclusions

FSQ-Brazil demonstrated good internal consistency, reproducibility and validity both by self-administration and by telephone interview. However, caution must be taken with the interpretation of quantitative scores of widespread pain index and symptoms severity scale, which slightly differed according the method (self-administration or interview) in our study.
Geographic Diversification and Banks’ Funding Costs
Authors: Levine Ross , Lin Chen , Xie Wensi
Published: July 2020

We assess the impact of geographic diversification on a bank’s costs of interest-bearing liabilities. We employ a new identification strategy and discover that geographic expansion across U.S. states lowered funding costs. Consistent with expansion facilitating risk diversification, we find that (1) funding costs fall more when banks expand into states whose economies are less correlated with the banks’ state and (2) geographic diversification reduces the costs of uninsured, but not insured, deposits. Consistent with expansion intensifying agency frictions, which puts upward pressures on funding costs, we discover that geographic diversification reduces the costs of interest-bearing liabilities more in better-monitored and better-run banks.

This paper was accepted by Tomasz Piskorski, finance.
Newly qualified health visitor: Adapting practice in difficult times
Authors: Boddy Bethany
Published: July 2020

Bethany Boddy reflects on the changes and challenges faced by health visitors during the coronavirus pandemic
Prognostic value of severity of dislocation in late-detected developmental dysplasia of the hip
Authors: Terjesen Terje , Horn Joachim
Published: July 2020

Purpose

The aims of this study were to evaluate the reliability of three classifications of severity of dislocation in late-detected developmental dysplasia of the hip (DDH), especially to assess whether they are predictive of long-term outcomes.

Methods

Two groups of patients were analyzed. Group 1 (57 patients, 69 hips) underwent closed reduction between 1958 and 1962. Mean age at reduction was 20.3 months (4 to 65). Group 2 (50 patients, 54 hips) treated between 1996 and 2005, was used for analysis of the association between severity of dislocation and treatment (open or closed reduction). The primary radiographs were graded according to the Tönnis classification, the classification of the International Hip Dysplasia Institute and a new method based on the position of the most lateral point of the proximal femoral metaphysis (lateral metaphysis height classification, LMH). The outcome at a mean age of 51.2 years (55 to 60) was graded according to the occurrence of osteoarthritis (OA) and total hip arthroplasty (THA).

Results

There were significant associations between the classifications, and the intra- and interobserver agreements were high. More severe grades of DDH were significantly associated with age ≥ 18 months and with open reduction. None of the classifications were significantly associated with long-term OA. The LMH method was significantly associated with the need for THA, whereas the other classifications were not.

Conclusion

All the classifications were reliable in grading severity of DDH. The LMH method seems preferable in clinical practice because the main landmarks were easy to define and because it had long-term prognostic value.

Level of Evidence

III
Improved thermal stress model and its application in ultraviolet nanosecond laser cleaning of paint
Authors: Lu Yao , Yang LiJun , Wang MaoLu , Wang Yang
Published: July 2020

A developed 2D finite element model to describe temperature distribution, stress distribution, and ablation depth by ultraviolet nanosecond (ns) pulsed laser cleaning is presented. In this paper, we indicate that thermal stress is the primary mechanism in the paint removal process by laser cleaning and successfully simulate the ultraviolet nanosecond (ns) pulsed laser cleaning by the finite element method. Notably, the formation of plasma, plasma shielding effect on the incident laser fluence, temperature-dependent absorptivity, and absorption coefficient of the paint layer are crucial factors considered in this model. In addition, the tailored model can predict theoretical cleaning of thresholds based on the mechanism of thermal stress. According to the temperature, stress distribution, and cleaning depth in paint and substrate at various laser fluence in this model, the corresponding cleaning threshold is

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in theory. In a word, it is expected that this study could provide a theoretical reference regarding laser cleaning paint layers and pave the way for reducing substrate damage in various industrial applications.
Tunable plasmon-induced transparency with a dielectric grating-coupled graphene structure for slowing terahertz waves
Authors: Wang Tianzhi , Yan Fei , Wang Ruoxing , Tian Fengjun , Li Li
Published: July 2020

We present a tunable plasmon-induced transparency (PIT) structure that is composed of dielectric grating and a graphene system to manipulate terahertz (THz) waves. The graphene system consists of a graphene sheet and a graphene ribbon layer, with a spacer between them. By exploiting the diffraction coupling of THz wave with dielectric grating, graphene plasmonic resonance is efficiently excited on both graphene sheet and graphene ribbons. This leads to the surface plasmon mode of the graphene sheet and the localized plasmon mode of the graphene ribbons. The coupling between the two-plasmon modes via near-field destructive interference generates a strong PIT effect with slowing the group velocity of THz waves. A group delay over 0.2 ps and group index beyond 170 can be achievable. The group slowing effect is dynamically tunable with varying the Fermi level of graphene. The work suggests a promising scheme for on-chip graphene slow-wave devices at the THz regime.
Networking a quiet community: South African Chinese news reporting and networking
Authors: van Wyk Barry
Published: July 2020

Half of all Chinese people living in Africa reside in South Africa, a community with a long history. On the surface, the South African Chinese community resembles a quiet community, yet it is actually a highly networked community that has developed networks and support structures to protect itself and to maintain its unique and vibrant identity in a dangerous environment. At the forefront of this is a community organization called the South African Chinese Community and Police Cooperation Centre. This community has also developed a home-grown South African Chinese language media to tell its own story. The South African Chinese media has been all but neglected by researchers and is analysed in depth here in English for the first time. This article examines six months of content, January–July 2017, produced by South African Chinese media, lifting the veil on news reporting and networking in the South African Chinese community.
Theorizing comic cons
Authors: Woo Benjamin , Johnson Brian , Beaty Bart , Campbell Miranda
Published: July 2020

When comics fandom emerged as a distinct media-oriented community in the 1960s, one of the things it brought with it from science-fiction fandoms was the convention. Buoyed by the synergistic relationship between Hollywood and the San Diego Comic-Con and the growing prominence of ‘geek’ culture, comic conventions, comic art festivals and related media fandom events across North America have enjoyed enhanced prestige, attention and attendance over the last fifteen to twenty years. But what kind of event are these ‘con events’? This article builds on a cultural mapping survey of convention organizers. The survey’s goal was to suggest something of the scope and diversity of the contemporary sector. Behind this variation, we define the con event as an organizational and cultural form that is (1) oriented to media, (2) audience-facing and (3) concerned with circulation.
Family stories in Italy and the United States: From Parenthood to Tutto può succedere
Authors: Natale Anna Lucia
Published: July 2020

This article provides an analysis of the TV series Tutto può succedere (‘Anything could happen’) (RAI 1, 2015–18), the Italian adaptation of the American format Parenthood (NBC, 2010–15). Assuming that every form of reproduction from an original text is always a ‘new story’, the main objective is to examine the narrative efficacy of the Italian adaptation both in terms of stylistic and expressive forms and cultural identity of the product. Through a qualitative analysis of the texts, I highlight the founding elements of the new story as compared to the original: a stronger enhancement of the family’s unity, an approach to everyday reality more in a private perspective and a cultural reworking of the female characters. I argue that Tutto può succedere is an effective adaptation, since it succeeds in giving the story a specific Italian identity (the value of family and motherhood), and in taking from Parenthood innovative forms of storytelling with respect to the Italian narrative tradition.
Defining problems and struggling to find solutions: Framing Roma people in Italian news websites
Authors: Famulari Umberto
Published: July 2020

This article employs a quantitative content analysis of news stories (N=600) to compare how six websites of Italian national newspapers of different political orientations framed Roma people during the campaign for the 2018 Italian general election and in the six months following the formation of the government coalition between the far-right Northern League party and the Five Star Movement. Drawing from framing theory and, in particular, looking at diagnostic and prognostic frames and sources interviewed and quoted, the article shows that when talking about the Roma community, a clear ideological divide between right-wing and progressive newspapers emerged. In a trend that follows the shifting Italian political landscape, news outlets that are historically considered as centrist gave prominence almost exclusively to stories about the removal of Roma camps, evictions and arrests while neglecting the coverage of programmes that would support and help the Roma community.
Il brand Gomorra: Dal romanzo alla serie TV, Giuliana Benvenuti (2018)
Authors: Moscardi Iuri
Published: July 2020

Review of: Il brand Gomorra: Dal romanzo alla serie TV, Giuliana Benvenuti (2018)

Bologna: Il Mulino, 208 pp.,

ISBN 978-8-81527-433-5, p/bk, €19.00
È stata Roma: La criminalità capitolina dal ‘poliziottesco’ a Suburra, Matteo Santandrea (2019)
Authors: Renga Dana
Published: July 2020

Review of: È stata Roma: La criminalità capitolina dal ‘poliziottesco’ a Suburra, Matteo Santandrea (2019)

Catanzaro: Rubbettino Editore, 212 pp.,

ISBN 978-8-84985-770-2, p/bk, €16.00
The talks on the Cyprus problem at Crans-Montana, Switzerland (28.06 – 07.07.17) and the Greek-Cypriot Press: The views of newspapers Alithia, Politis and Haravgi
Authors: Antoniades Euripides
Published: July 2020

This paper focuses on the period of negotiations between the Greek-Cypriot and Turkish-Cypriot community at Crans-Montana, Switzerland, from 28 June to 7 July 2017. It looks into the views of the three leading Greek-Cypriot newspapers of that period and aims to present the positions of each newspaper about the negotiations on the Cyprus problem, at political level. Articles from three newspapers (Alithia, Politis and Haravgi) were studied, with an emphasis on political coverage regarding the negotiations. For the Crans-Montana negotiations on the Cyprus problem, the agenda setting approach was used, according to which, an event becomes an important from a journalist’s perspective, not only because it is unexpected and/ or dramatic, but also because it attracts a great deal of public attention and the significance of the event itself may, for example, lead to intense public judgment, tension or concerns. The research questions of the paper were shaped as follows: Τo what extent were the newspapers in favour of a solution to the problem? Did they have a conflicting or reconciling tone? To what extent did the style and tone of the news items regarding the talks vary depending on the newspaper? To what extent did the news items focus on persons taking part in the talks and the topics of the talks? Were the articles signed or not? Findings suggest that the Greek Cypriot press during the negotiations have faith that the Cyprus issue can be resolved through the talks. The overarching aim is to understand the efforts made to solve the Cyprus problem through the negotiations in Switzerland and to examine the positions of the Cypriot press regarding this thorny and crucial issue, over which the Republic of Cyprus has been agonising for more than forty years.
Desde Marcus Welby, M.D. hasta The resident: los cambios en las representaciones de los médicos en las series de televisión
Authors: Cambra-Badii Irene , Guardiola Elena , Baños Josep-E.
Published: July 2020

La forma en que las series de televisión representan a los médicos ha cambiado a lo largo de los años. En las primeras, los personajes principales eran buenos, pacíficos, inteligentes, competentes, empáticos y exitosos. Por ejemplo, Marcus Welby M.D. (TV) de David Victor (Estados Unidos), que este año cumple 50 años desde su primera emisión. Esta representación comenzó a cambiar a mediados de la década de 1990. Mientras mantenían una imagen positiva, se comenzó a poner más énfasis en sus características negativas, y sus dificultades en las relaciones interpersonales, como ER (TV) de Michael Crichton (Estados Unidos) y Doctor House (TV) de David Shore (Estados Unidos). Los médicos fueron descritos como arrogantes, codiciosos y adúlteros, y se mostraban sus errores. Las últimas dos series estrenadas son The Good Doctor (TV) de David Shore (Estados Unidos), con un residente de cirugía con autismo y síndrome de Savant, y The Resident (TV) de Amy Holden Jones, Hayley Schore y Roshan Sethi (Estados Unidos), donde aparecen serios problemas institucionales. Estas series pueden ser útiles como un método para discutir problemas de la ética médica mediante ejemplos positivos o negativos, y también ayudan a representar los cambios en la imagen de los médicos en las últimas décadas, discutiendo las razones de estos cambios.
Aula de campo no projeto TAMAR: conscientizando alunos do nível 1 da educação infantil, sobre os cuidados e sobrevivência das tartarugas no habitat de proteção / Field lesson in the TAMAR project: raising awareness among students of level 1 of early childhood education about the care and survival of turtles in the protection habitat
Authors: Domingos Lucilene Emidio , Silva José Geraldo Ferreira da
Published: July 2020

Alunos da Educação Infantil realizam atividades diversificadas dentro e fora de sala de aula juntos de seus professores, em espaços formal e não formal, levando consigo conhecimentos prévios para a aula de campo, onde expressaram suas curiosidades relacionadas ao meio ambiente que foram visitar. O objetivo deste artigo é conhecer a vida da tartaruga marinha; reconhecer algumas interações entre seres vivos e conscientizar sobre questões ambientais pensando na preservação da espécie animal e cuidados com o meio ambiente marinho através do projeto TAMAR. Para coleta de dados foram realizadas observações e desenvolvimentos de planejamentos com alunos do nível 1 por 10 dias letivos. Os dados que foram colhidos e analisados de forma descritivas e interpretativa. Conforme as aula iam acontecendo os alunos mostraram bastante interesse em conhecer e aprimorar os conhecimentos, o entusiasmo dos aluno foi ainda maior na aula de campo no Projeto TAMAR a sensibilização diante que eles viam foi verificado de acordo com as reações de gritos eufóricos, gargalhadas, perguntas a monitora do projeto TAMAR, admiração frente as informações recebidas e espanto visto que muitas tartarugas morem por causa do lixo que são jogados no mar.Palavras chave: Meio Ambiente. Educação Ambiental. Projeto TAMAR. Aula de Campo e Sensibilização.
Declínio do Número de Alunos da Escola Salesiana Padre Rinaldi: Uma proposta de Melhoria / Decline of the Number of Students of the Salesian School Padre Rinaldi: A Proposal for Improving
Authors: Lima Júnior José Lopes , Escudero Jaime Caiceo
Published: July 2020

A Administração evolui com o tempo e desenvolve modelos de gestão que responde ao contexto temporal e socioeconômico em que a Organização está inserida. Administração Estatégica conjugada com Administração da Qualidade é um modelo de Gestão Contemporãneo. A proposta de melhoria proposta a Escola Salesiana Padre Rinaldi, visando reduzir ou parar o declínio do número de seus alunos tem estratégias nos âmbitos de pessoal, financeiro e pedagógico, fundadas numa Administração Estratégica e de Qualidade Total, com o envolvimento de todos os integrantes da Comunidade Educativo-Pastoral. Palavras chave: Administração. Administração Estratégica. Administração de Qualidade Total. Gestão de Pessoal. Gestão Financeira. Gestão Pedagógica. Estratégias. Comunidade Educativo-Pastoral (CEP).
A Alienação Parental e a proteção dos Direitos Fundamentais da Criança e do Adolescente: Uma Revisão Integrativa / Parental Alienation and the Protection of Fundamental Rights of Children and Adolescents: An Integrative Review
Authors: Soares José Paulo Egito , Lopes Flavio Alix De Amorim Barreto , Rocha Marcos Murilo Mattos , Santos Felipe Santana Silveira , Soares Ronaldo
Published: July 2020

O presente artigo tem como objetivo abordar sobre a alienação parental, e o direito a convivência familiar da criança, com os seus genitores após o divórcio. A importância desse estudo se justifica devido ao elevadíssimo grau de “estado de guerra” entre os pais que não conseguem superar suas dificuldades sem envolver os filhos, bem como a existência de graves acusações cometidas contra o genitor (a) que se encontra afastado (a) do seu filho. A coleta de artigos foi pesquisada na base de dados online na base de dados Scielo e por meio de estudo profundo de doutrinadores especializados no Direito Civil, de pensadores pioneiros na teoria da alienação parental e de artigos jurídicos especializados, bem como meios para o equilíbrio familiar, utilizando-se para tal a pesquisa bibliográfica. Conclui-se que lutar contra a alienação parental é uma obrigação de toda a sociedade, não cabendo apenas ao Poder Público velar pela observância dos direitos fundamentais apostos na Carta Política de 1988, bem como no Estatuto da Criança e do Menor Adolescente em que se asseguram prerrogativas às crianças e aos adolescentes, tais como o direito ao respeito, à convivência familiar, à dignidade e, mormente, à inviolabilidade da integridade física, psíquica e moral.
Erupção Dentária Ectópica e o Impacto sobre a Cavidade Oral: Revisão de Literatura / Ectopic Dental Eruption and the Impact on Oral Cavity: Literature Review
Authors: Siles Edeile Roberta Azevedo , Fernandes Felipe Santana , Brito Rafaela Souza , Pinchemel Edite Novais Borges
Published: July 2020

O objetivo do presente estudo foi revisar a literatura atual existente sobre a impactação dentária e a consequência da modificação da posição dos dentes na arcada dentária e produzir uma revisão simples de literatura com os dados encontrados. Foram selecionados 46 artigos em Inglês, Português e Espanhol das bases de dados LILACS, PubMed e MEDLINE, limitando os anos de publicação entre 2015 e 2020, utilizando as palavras chave: “dente supranumerário, erupção dentária, erupção ectópica de dente”. Após a aplicação dos critérios de inclusão e exclusão, remoção de duplicatas, seleção baseado em seus títulos, resumos e leitura na integra, restaram apenas 13 artigos. Estes artigos foram analisados e descritos em uma revisão simples de literatura. A erupção ectópica de dentes é uma patologia que deve ser avaliada. Acomete cada vez mais pacientes, e seu tratamento deve ser individualizado a cada paciente e necessidade.
Marked Elevation of Lipase in COVID-19 Disease: A Cohort Study
Authors: Barlass Usman , Wiliams Brett , Dhana Klodian , Adnan Darbaz , Khan Shahab R. , Mahdavinia Mahboobeh , Bishehsari Faraz
Published: July 2020

INTRODUCTION:

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causing the pandemic of coronavirus disease 2019 (COVID-19) is a global health crisis. Possible pancreatic involvement has recently been observed in these patients; however, its significance is unclear. The aim of this study was to evaluate the association of significantly elevated lipase with disease outcomes.

METHODS:

Data about demographics, symptoms, laboratory values, and clinical outcomes were collected for 1,003 consecutive patients testing positive for COVID-19. Elevated lipase was defined as greater than 3 times the upper limit of normal (>3 × ULN). Baseline characteristics among patients with or without elevated lipase were compared using Fisher exact test or Student t-test for categorical or numerical variables, respectively. Logistic regression was used to evaluate the association of lipase levels with primary clinical outcomes (intensive care unit admission and intubation) adjusted for age, sex, body mass index, history of diabetes, and hypertension.

RESULTS:

Of 1,003 patients with COVID-19, 83 had available lipase levels and were all admitted to the hospital. Of 83, 14 (16.8%) had elevated lipase (>3 × ULN), which was associated with higher rates of leukocytosis (P < 0.001) and abnormal liver enzymes (P < 0.01). Compared with lower lipase levels (<3 × ULN), patients with elevated lipase had higher rates of ICU admission (92.9% vs 32.8%; P < 0.001) and intubation (78.6% vs 23.5%; P 0.002). In a multivariable-adjusted model, higher lipase levels were significantly associated with admission to the ICU and rate of intubation.

DISCUSSION:

Lipase elevation is seen in COVID-19 and is associated with worse disease outcomes.
SEKOLAH DREAMABLE : Sebuah Upaya Meningkatkan Kemandirian Anak Berkebutuhan Khusus (Studi Implementasi Program CSR PT Pertamina (Persero) Fuel Terminal Bandung Group)
Authors: Indriyani Intan Lukfia , Gokhan Gokhan , Aditya Rahadiyand , Perdana Geri Puspa , Isnaeni Anis Putri
Published: July 2020

Education in Indonesia is still difficult for some segments such as ABK who have escaped maximum attention and management. Although there has been government assistance to provide access to education that is appropriate for every child through inclusive education. However, it still requires challenges, such as the lack of complete learning support facilities for ABK, expensive and distant schools, teachers who need knowledge about ABK, and others. Then the roles of various sectors are needed in efforts to fulfill disability rights. This study uses a qualitative descriptive approach that describes the implementation of CSR programs in handling ABK. This research was conducted at the Sekolah Dreamable located in Tegalluar village, Bojongsoang District, Bandung Regency, West Java. Data collection techniques using interview techniques and study documentation. The results of this study indicate that PT Pertamina (Persero) Fuel Terminal Bandung Group in CSR programs implementing at Sekolah Dreamablein Bojongsoang District, Bandung uses a combination program strategy pattern that combines centralized and decentralized program patterns. Where in planning, the program determination and implementation involves the participation of various stakeholders. As a form of implementation, CSR that has been carried out by PT Pertamina (Persero) Fuel Terminal Bandung Group not only consists of Charity such as complimentary books and school supplements but also Philanthropy such as School Development and the procurement of Homecare Cars, and Community Development through purchasing the capacity of Teachers and Special Needs.Keywords: Corporate Social Responsibility, ABK Handling, Inclusive Education
Aeromagnetic mapping of fault architecture along Lagos–Ore axis, southwestern Nigeria
Authors: Oladejo Olagoke Peter , Adagunodo Theophilus Aanuoluwa , Sunmonu Lukman Ayobami , Adabanija Moruffdeen Adedapo , Enemuwe Charity Adaeze , Isibor Patrick Omoregie
Published: July 2020

A seismic wave is released when there is sudden displacement on a fault plane. The passage of this wave along the fault plane or within the lithosphere could result in ground shaking or vibration at the surface of the Earth. To provide a geophysical explanation to this phenomenon, the high-resolution aeromagnetic data of the sedimentary terrain and part of the Basement Complex of Southwestern Nigeria were processed and interpreted to provide fault architecture of the area, which could serve as conduit for the passage of seismic energy in the study area. High-resolution aeromagnetic data along the Lagos–Ore axis are processed for fault mapping in the study area. The reduced-to-equator (RTE) residual aeromagnetic data used were enhanced using the total horizontal derivative (THD) and upward continuation (UC) filtering techniques on Oasis Montaj 6.4.2 (HJ) software. The resultant maps were overlaid and compared with the plotted RTE residual maps for relevant interpretations. Varying signatures of magnetic anomalies are grouped into high (57.9–89.1 nT), intermediate (38.2–57.9 nT), and low (4.0–38.2 nT) magnetic intensities, which are associated with contracting basement rocks features. The obtained lineaments from the THD reveal areas of various deformations such as brittle, which is associated with faults/fractures, and ductile deformation, which is associated with folds of geological features. The faults, as depict by the UC map, reveal different depth ranges of 500–2250 m at the western side and 1,500–1,250 m at the northwestern area of the study. Since it has been on record that September 11, 2009, earth tremor of magnitude 4.4, with the epicenter at Allada, Bennin Republic, 128 km west of Lagos, Nigeria occurred within the study area, it can be inferred that the established geologic fault architecture could be responsible for the hazard and be part or synthetic to the Ifewara-Zungeru fault in Nigeria.
Trastuzumab-induced thrombocytopenia after eight cycles of trastuzumab treatment
Authors: Zhou Qiong , Dong Jie , Jiang Xiaodong , Pan Yueyin , Han Xinghua
Published: July 2020

Trastuzumab, a humanized monoclonal antibody derived from recombinant DNA, is used in patients with breast cancer with HER2 gene amplification. The survival benefit from trastuzumab has been well established in patients with early and metastatic breast cancer who had over expression of HER2. We reported a case of severe thrombocytopenia after eight cycles of trastuzumab treatment for breast cancer. Before the 9th trastuzumab treatment, the patient’s platelet decreased to 48 × 109/L. Recombinant human thrombopoietin was used, and the platelet level increased to normal level. Before the 10th treatment, the platelet count of the patient was 99 × 109/L. However, during the 10th and 11th trastuzumab treatment, the platelet count decreased to 5 × 109/L in 24 h. After treatment with TPO and corticosteroids, the platelet levels increased to the normal level in 7 days. Trastuzumab-induced thrombocytopenia is rare but still occurred even after 8 cycles of trastuzumab treatment.
Medical Confidentiality after Patient Death in Selected Civil and Common Law Systems
Authors: Bagan-Kurluta Katarzyna , Drozdowska Urszula
Published: July 2020

The paper presents problems related to medical confidentiality after the patient’s death. The reasons for the waiver of this secret need to be considered. To this end, the authors analysed Polish regulations of medical law and then compared them to selected European regulations: French and English law. The inspiration for describing these two legal orders were two media-highlighted cases of the publication of medical diaries after the deaths of people holding the highest state offices: Lord Moran and Dr. Claude Gubler. The first doctor published his memoirs concerning the state of health of the English statesman of World War II – Winston Churchill, while the second published his memoirs after the death of the French President – François Mitterrand. The authors describe the reaction of the law to these breaches of secrecy after the deaths of the patients, and confront them with the current regulations. The whole is crowned with conclusions resulting from the comparison of Polish, French and English law. The paper uses the dogmatic-legal and comparative methods.
Medical Secrets vs. GDPR
Authors: Zaremba Joanna
Published: July 2020

The work of the doctor and other health professionals is closely related with access to information on the health of patients. The disclosure of such information leads to many consequences. It also violates the privacy of the patient.The obligation to maintain medical confidentiality is regulated by law, and is based on the ethics of the medical profession. Regulations that regulate the principles of medical confidentiality are contained in the Act of 5 December 1996 on the professions of doctor and dentist. Information on the health of patients is covered by special confidentiality, because these are specific data requiring confidentiality.

The information that relates to the patient and is obtained during medical work, including data on the patient’s life or property, are medical secrets. There are a few exceptions for which the doctor may be released from medical confidentiality. These include consent of the patient him/herself, consent resulting from the act and removal of medical confidentiality in the case of danger to the patient or other persons, and with the consent of public authorities.

It is very important to consider the protection of personal data, including sensitive data, which includes medical data contained in the provisions of the GDPR. This regulation comprehensively regulates the issues of personal data protection, also including medical confidentiality, by prohibiting the processing of patient data by medical entities without authorization.

The purpose of this article was to analyze the correlation between regulations relating to medical confidentiality and the provisions of the GDPR, which are new tools for the protection of personal data. The article discusses issues regarding the subject scope of medical confidentiality, exemption from its behaviour, and liability for possible violations.
The natural history and treatment of non-functioning pituitary adenomas (non-functioning PitNETs)
Authors: Yavropoulou Maria P , Tsoli Marina , Barkas Konstantinos , Kaltsas Gregory , Grossman Ashley
Published: July 2020

Non-functioning pituitary adenomas, recently alternatively termed pituitary neuroendocrine tumours (NFpitNETs), are mostly benign neoplasms that are not associated with a hormonal hypersecretory syndrome. The clinical spectrum of NFpitNETs varies from completely asymptomatic to the development of panhypopituitarism and manifestations attributed to mass effects on nearby structures. NFpitNETs follow generally an indolent course, but in 5–10% of cases they exhibit more aggressive behaviour, characterised by rapid growth, invasiveness and early recurrence. The initial size of the adenoma, the presence of symptoms and the histological subtype are related to the natural course of NFpitNETs. Active surveillance is usually the strategy of choice in the case of an asymptomatic NFpitNET, while surgical resection is recommended in case of visual and/or neurological abnormalities or rapid tumour growth. Based on previous and emerging data, approximately 50% of patients show tumour growth, while 20% of patients with NF-macroadenomas on active surveillance may require further intervention during a follow-up period of 7 years. Adjuvant radiotherapy is usually considered for large residual tumours or recurrent and/or aggressive adenomas, but there is evidence that medical therapy, especially with cabergoline, can occasionally be beneficial, whereas newer molecular agents are under investigation. Thus, while highly effective medical therapy is awaited, a move towards a more conservative approach seems appropriate, at least until we have better molecular markers of progressiveness.
La paz y el desarrollo sostenible en el campo educativo, una relación visible o invisible
Authors: Filut Damian
Published: July 2020

Los conceptos paz y desarrollo sostenible hacen parte integral del diálogo en el campo del desarrollo internacional y también se ven reflejados en los programas de estudio de varios países. Esta investigación busca identificar la relación entre estos dos conceptos en el marco de la educación y la manera como se evidencia dicha relación en la práctica educativa. Se toma el caso de la educación para el desarrollo sostenible en Israel, el cual cuenta con un programa nacional en el Ministerio de Educación. Teniendo como referencia a la Red Verde –una de las organizaciones a cargo de la formación docente en esta materia–, se busca entender esta relación y su carácter. Los resultados obtenidos son producto del análisis de documentos oficiales israelíes para una primera contextualización, y cuestionarios en línea y entrevistas semiestructuradas a capacitadores de educación para el desarrollo sostenible. Estos nos muestran la gran importancia del contexto en el momento de tratar un tema como la paz y cómo la educación para la sustentabilidad podría tener un lugar fundamental para conseguirla.
O uso crítico da memória nas narrativas jornalísticas sobre o rompimento da barragem da Vale
Authors: Maia Marta Regina
Published: July 2020

Averiguar o uso crítico da memória na cobertura jornalística de situações impactantes é o objetivo deste artigo, que tem como proposta a reflexão sobre dois acontecimentos próximos que ocorreram no estado de Minas Gerais no século XXI. O propósito é analisar a cobertura dos jornais Folha de S. Paulo, O Estado de S. Paulo e O Globo sobre o rompimento da barragem da Vale, em 2019, em Brumadinho, e sua relação com o rompimento da barragem da Samarco, em 2015, em Mariana, por intermédio de uma análise de conteúdo, que apresenta como eixos operadores os “portadores de memória” identificados como “Fenômenos” e “Sujeitos”. Este olhar está ancorado nos conceitos de acontecimento e memória, em associação com o papel testemunhal do jornalismo. Nota-se que a cobertura proporcionou um relativo destaque para a conexão entre os dois acontecimentos recorrendo ao uso crítico da memória.
Perfil de força de preensão manual em pacientes idosos com câncer de próstata
Authors: Tavares Marcelo Caetano de Azevedo , Souza Filho Breno Augusto Bormann , Barbosa Humberto de Moura , Vanderley Isabel Cristina Sibalde
Published: July 2020

Objetivo: analisar o perfil de Força de Preensão Manual em pacientes idosos com câncer de próstata, atendidos em instituição hospitalar filantrópica do Recife.Métodos: estudo transversal com análise de dados secundários, coletados no Ambulatório de Oncogeriatria do Instituto de Medicina Integral Professor Fernando Figueira, utilizando uma amostra por conveniência com uma amostragem de 72 idosos. A análise estatística foi realizada utilizando o programa estatístico STATA 12. O teste de Kolmogorov-Smirnov foi aplicado a variáveis numéricas para se determinar a normalidade da amostra. Em caso de não normalidade, foi utilizado o teste de Mann-Whitney. Adotou-se o nível de significância de 0,05%.Resultados: observou-se uma Força de Preensão Manual reduzida nos pacientes com estadiamento de uma doença mais avançada quando comparado a outros estágios mais localizados ou clinicamente melhores (estadiamento I: 27,78 vs. estadiamento IV: 27,20 no braço dominante (p=0, 340)/ estadiamento I: 27,33 vs. estadiamento IV: 24,13 no braço não dominante) sendo esse resultado melhor reproduzido na mão não dominante (p=0,090). Por meio da análise das comorbidades (hipertensão, diabetes, cardiomiopatia e osteoartrite) em relação à mão dominante e não dominante, não foram verificadas diferenças significativas na Força de Preensão Manual na presença ou ausência das comorbidades analisadas tanto na mão dominante quanto da não dominante (p=0,189 vs.p=0,437).Conclusões: o estudo trouxe subsídios relevantes sobre a importância da Força de Preensão Manual como um importante parâmetro geral para força e um indicativo de saúde, principalmente quando analisados em idosos com câncer, onde afeta significativamente sua função física e neuromuscular, incluindo atrofia muscular, diminuição da força muscular e diminuição do desempenho funcional em atividades diárias, comprometendo significativamente a qualidade de vida e seu prognóstico.
“Für die Falaschas”: Das Internationale »Pro-Falascha-Comité« in Deutschland
Authors: Jankowski Alice
Published: July 2020

The activities of the German branch of the International Pro-Falasha Committee before World War I are quite unknown. A twofold document from 1914, a circular letter, asking the German Jewry for assistance for the Falasha, and the attached membership-list are considered. The article tries to explore the reasons, why such a Jewish association was established, and why at that time. It also focusses on the motivations of the German participants, their social and academic backgrounds and their networking. Fitting well into the then vivid “Jewish renaissance”, the image of an untouched Jewry, surviving in Ethiopia from pre-rabbinical times on, may then have fulfilled multiple purposes for the Europeans: Rescuing brethren abroad – by the idea of Jewish self-help and Jewish faith, all together combined with a belief in European superiority –, rejection of Christian missionary efforts, self-assertion and resistance against the Christian majority, and the sharpening of an unique Jewish identity.
Girma Y. Getahun: Advanced Amharic Lexicon: a Supplement to Concise Amharic–English Dictionaries
Authors: Teferra Anbessa
Published: July 2020

Review
The Jesuits in Ethiopia: Missionary Methods and Local Responses to Catholicism (1555–1632)
Authors: Cohen Shabot Leonardo
Published: July 2020

Dissertation Abstract
Addenda to the Bibliography of Reidulf K. Molvaer: Fieldwork, Serendipity, and Ethiopian Women in Aethiopica 10 (2007)
Authors: Molvaer Reidulf K.
Published: July 2020

Miscellaneous ArticleATTENTION: Due to copy-right no online publication is provided.
In memoriam Taddäsä Bäyyänä (1936–2006)
Authors: Yimam Baye
Published: July 2020

Obituary
In memoriam Marvin Lionel Bender (1934-2008)
Authors: Hudson Grover
Published: July 2020

Obituary
Teodros Kiros: Zara Yacob. A Seventeenth Century Rationalist: Philosopher of the Rationality of the Heart
Authors: Krause Andrej
Published: July 2020

Review
Ivo Strecker - Jean Lydall (eds.): The Perils of Face. Essays on Cultural Contact, Respect and Self-esteem in Southern Ethiopia
Authors: Dohrmann Alke
Published: July 2020

Review
Reflections on Abu Rumi’s Amharic Translation of the Book of Ruth
Authors: Mulugetta Meley
Published: July 2020

This article will look at Abu Rumi’s Amharic rendering of the Book of Ruth with close comparison to the ancient and modern versions of the Bible, especially the Gǝ’ǝz, the Masoretic and the Septuaginta texts. The article will also look at the extent of Abu Rumi’s close reading of the Hebrew text and the degree to which he successfully transmits to us the full impact of the Hebrew story with all its niceties.
Eine apotropäische Segensformel in den äthio-sabäischen Königsinschriften
Authors: Nebes Norbert
Published: July 2020

Miscellaneous Article
A Mechanical Clock from Venice for Emperor Dawit of Ethiopia
Authors: Mulugetta Meley
Published: July 2020

Miscellaneous Article
Tewodros Bomba: Discovery of an Unpublished Letter from Aṣe Tewodros to “Ǝtege” Yätämäññu
Authors: Pankhurst Richard K.P.
Published: July 2020

Miscellaneous Article
A Psalter from Tübingen: Although Inconspicuous the Text, Neverthless a Treasure for Manuscriptology
Authors: Six Veronika
Published: July 2020

The University Library of Tübingen, Germany, has acquired a manuscript with the text of a Mäzmurä Dawit. The manuscript is dated. At first glance it seems to be the standard Psalter. But there are several criteria, which give insight into the manuscript culture, and which has not changed during centuries. The modern printed editions of a Mäzmurä Dawit exactly follow the scheme of the long tradition. Besides being a perfect witness to the traditional manuscript culture and individual use of a Mäzmurä Dawit, the Tübingen manuscript contains elements, which open the window to different aspects, as for example, worship and belief, iconography, or history.
Hermann Amborn: Flexibel aus Tradition: Burji in Äthiopien und Kenia
Authors: Abbink Jon
Published: July 2020

Review
In memoriam Alexander Naty (1957-2003)
Authors: Smidt Wolbert G.C.
Published: July 2020

Obituary
Michael Waltisberg: Die St-Stämme des Altäthiopischen
Authors: Goldenberg Gideon
Published: July 2020

Review
Girma Fisseha (Hrsg.): Äthiopien. Christentum zwischen Orient und Afrika
Authors: Priess Maija
Published: July 2020

Review
Eduard Zander Abenteurer, Naturforscher, Maler, Architekt und Handwerker in Äthiopien – Eine Biographie
Authors: Gräber Gerd
Published: July 2020

Though Eduard Zander’s original sketchbook with drawings in pen and ink – showing the remote Simen Mountain area – is still preserved in London, his adventuresome life and his scientific and artistic work as a biologist, architect or artisan is scarcely known in 19th century Ethiopian history. In the present article the author makes an attempt at Zander’s biography, adding the missing links and correcting the errors of his few predecessors; furthermore, he tries to produce recently dicovered source-material in an updated form.
The “Egyptian Saints” of the Abyssinian Hagiography
Authors: Marrassini Paolo
Published: July 2020

It seems possible to isolate a group of saints born in Egypt (or living there for a long time), different from the traditional saints of that country mainly because they were not martyrs, and substituted the martyrdom by penances and absolute asceticism; the presence of the desert is much more pronounced than in the rest of Abyssinian hagiography, and nearly absolute; the activity of the devil is also very heavily marked; almost all of them are of “Roman” birth or connection. They are Bula/Abib, Gabra Krestos/Alexius, Latṣun, Nob, Gabra Manfas Qeddus, John the Oriental, maybe Tadēwos of Dabra Bartarwa, Yoḥanni of Däbrä ʿAśa, and some others, to which the “Aksumite” saints must be added. The relationship of these saints among themselves is also demonstrated by the codices, in which the “Life” or the hymnography pertaining to one or more of them occur together with those of some of the others, in different combinations.