bluuebunny/crossref_metadata_2025 huggingface dataset:
A interculturalidade como estratégiade aproximação entre pesquisadores brasileiros e hispano-americanos na perspectiva da descolonização
Authors: Munsberg João Alberto Steffen , Silva Gilberto Ferreira da
Published: June 2018

Este texto aborda o tema da interculturalidade na perspectiva da decolonialidade na Amrica Latina. O assunto se insere na tendncia contempornea de investigaes e reflexes sobre um pensamento outro, com pretenso e abordagem distintas do que defendido pela modernidade eurocntrica. Objetiva-se compreender melhor as causas da dificuldade de insero efetiva do Brasil na Amrica Latina e apontar possveis caminhos para a aproximao das naes. Metodologicamente, este texto resulta de um estudo de cunho bibliogrfico exploratrio, com reflexes a partir de aportes tericos de pensadores do Grupo Modernidade/Colonialidade e afins. sabido que o Brasil se volta poltica, econmica e culturalmente para o Atlntico Norte, de costas para a Amrica Hispnica. Pensa-se que a interculturalidade a educao intercultural, de modo especial , se constitua em possvel fator propulsor da integrao, podendo ser o caminho para a aproximao entre pesquisadores brasileiros e hispano-americanos na perspectiva da descolonizao.
Transcriptional expression of PmrB and arnA within polymyxin-resistant nosocomial isolates of Pseudomonas aeruginosa from India
Authors: ROY Sayani , PAUL Deepjyoti , ELİZABETH Rajkumari , DHAR Debadatta , CHAKARVARTY Atanu , BHATTACHARJEE Amitabha
Published: June 2018

ABSTRACT

Objective: The polymyxin group of antibiotics is considered to be

one of the most effective antimicrobial agents against many serious pathogenic

bacteria, but the excessive use of these antibiotics has led to the development

of drug resistance among bacteria. This study was designed to characterize polymyxin-resistant

P. aeruginosa and to explore the role

of PmrB and arnA in resistant phenotype.

Methods:

mRNA and cDNA of five selected polymyxin-resistant strains representing

different MIC range; isolated under normal condition of  strain growth, after treating sample/media

with FeCl3 and MgCl2 alone, or after treating with FeCl3 and polymyxin

antibiotic. The transcriptional expression was observed for PmrB and arnA by quantitative real time RT-PCR in reference to P. aeruginosa PAO1. The presence of

plasmid mediated colistin resistance determinants mcr-1 was screened by PCR. Susceptibility of the strains was

determined by disc-diffusion method and DNA fingerprinting was carried out by

performing REP-PCR.

Results: A

down regulated expression of PmrB and

arnA was observed even after the

unique induction with FeCl3 and MgCl2. All the isolates were found to be

resistant against cefepime and different clonal patterns of resistance were

found among the isolates.

Conclusion: This study has drawn a new insight into polymyxin

resistance which will help in the detection and control of infections caused by

multidrug resistant P. aeruginosa.

The low susceptibility rate to aminoglycoside, piperacllin-tazobactam and

ciprofloxacin was found and in addition, detection of PmrB and arnA as

molecular markers in the follow up of infections caused by multidrug resistant P. aeruginosa. J Microbiol Infect Dis 2018; 8(2):61-68.
Endocarditis due to Aortic Root Abscess in a Patient with Rupture of Sinus of Valsalva
Authors: ALİ Arif Maqsood , WASEEM Gule Rana , ARİF Shazia
Published: June 2018

A

ruptured sinus of Valsalva aneurysm rarely accompanies the aortic valve

endocarditis. A 40-year old female presented with low threshold exertional

dyspnea and fever. Transthoracic and transesophageal echocardiography showed

ruptured sinus of Valsalva aneurysm in right ventricle with multiple vegetation

at the aortic root. Initial blood cultures were negative and an empirical

antibiotic therapy was started. Patient was operated for surgical repair of

sinus of Valsalva aneurysm. An aortic root abscess with rupture of sinus of

Valsalva was found at operation. However, postoperatively she developed sepsis

and multiorgan failure leading to her death. J Microbiol Infect Dis 2018; 8(2):69-72
SOME PHYSIOLOGICAL ASPECTS OF PHYTOEXTRACTION OF HEAVY METALS
Authors: Valiev R.Sh. , Olshanskaya L.N.
Published: June 2018

Mechanisms of ions intake into cells and carrier proteins of heavy metals are described. Classification of heavy metals on their biological role in the biosphere was carried out. Some information on the features of metals in body cells is given.
Long-term antigen exposure irreversibly modifies metabolic requirements for T cell function
Authors: Bettonville Marie , d'Aria Stefania , Weatherly Kathleen , Porporato Paolo E , Zhang Jinyu , Bousbata Sabrina , Sonveaux Pierre , Braun Michel Y
Published: June 2018

Energy metabolism is essential for T cell function. However, how persistent antigenic stimulation affects T cell metabolism is unknown. Here, we report that long-term in vivo antigenic exposure induced a specific deficit in numerous metabolic enzymes. Accordingly, T cells exhibited low basal glycolytic flux and limited respiratory capacity. Strikingly, blockade of inhibitory receptor PD-1 stimulated the production of IFNγ in chronic T cells, but failed to shift their metabolism towards aerobic glycolysis, as observed in effector T cells. Instead, chronic T cells appeared to rely on oxidative phosphorylation (OXPHOS) and fatty acid oxidation (FAO) to produce ATP for IFNγ synthesis. Check-point blockade, however, increased mitochondrial production of superoxide and reduced viability and effector function. Thus, in the absence of a glycolytic switch, PD-1-mediated inhibition appears essential for limiting oxidative metabolism linked to effector function in chronic T cells, thereby promoting survival and functional fitness.
Spatial cell firing during virtual navigation of open arenas by head-restrained mice
Authors: Chen Guifen , King John Andrew , Lu Yi , Cacucci Francesca , Burgess Neil
Published: June 2018

We present a mouse virtual reality (VR) system which restrains head-movements to horizontal rotations, compatible with multi-photon imaging. This system allows expression of the spatial navigation and neuronal firing patterns characteristic of real open arenas (R). Comparing VR to R: place and grid, but not head-direction, cell firing had broader spatial tuning; place, but not grid, cell firing was more directional; theta frequency increased less with running speed, whereas increases in firing rates with running speed and place and grid cells' theta phase precession were similar. These results suggest that the omni-directional place cell firing in R may require local-cues unavailable in VR, and that the scale of grid and place cell firing patterns, and theta frequency, reflect translational motion inferred from both virtual (visual and proprioceptive) and real (vestibular translation and extra-maze) cues. By contrast, firing rates and theta phase precession appear to reflect visual and proprioceptive cues alone.
Availability of Nanopore sequences in the genome taxonomy for Vibrionaceae systematics: Rumoiensis clade species as a test case
Authors: Tanaka Mami , Mino Sayaka , Ogura Yoshitoshi , Hayashi Tetsuya , Sawabe Tomoo
Published: June 2018

Whole genome sequence comparisons have become essential for establishing a robust scheme in bacterial taxonomy. To generalize this genome-based taxonomy, fast, reliable, and cost-effective genome sequencing methodologies are required. MinION, the palm-sized sequencer from Oxford Nanopore Technologies, enables rapid sequencing of bacterial genomes using minimal laboratory resources. Here we tested the ability of Nanopore sequences for the genome-based taxonomy of Vibrionaceae and compared Nanopore-only assemblies to complete genomes of five Rumoiensis clade species: Vibrio aphrogenes, V. algivorus, V. casei, V. litoralis, and V. rumoiensis. Comparison of overall genome relatedness indices (OGRI) and multilocus sequence analysis (MLSA) based on Nanopore-only assembly and Illumina or hybrid assemblies revealed that errors in Nanopore-only assembly do not influence average nucleotide identity (ANI), in silico DNA-DNA hybridization (DDH), G+C content, or MLSA tree topology in Vibrionaceae. Our results show that the genome sequences from Nanopore-based approach can be used for rapid species identification based on the OGRI and MLSA.
Hydrogen as Sustainable and Green Energy Resource
Authors: Dutta Suman
Published: June 2018

Hydrogen is a clean fuel that can be used as the major energy resource. Hydrogen can be produced from various renewable and sustainable sources. Cost of hydrogen is high when it is produced from alternative sources. Hydrogen can be utilized as an energy source when it can be produced from cheap and renewable source. Emphasis should be given to those methods that have a lowCO2footprint. Purification, transportation, and storing are important aspects that can be emphasized. Hydrogen is used as fuel in internal combustion engine (ICE) and fuel cell electric vehicle (FCEV). The cost ofFCEVis higher than car withICE. However, theFCEVshave more fuel efficiency thanICEcar. Suitable materials should be developed for storing hydrogen in both liquid and compressed gas form. Lightweight, high mechanical strength, and low‐cost materials are preferred for this purpose. Safety issues should be taken care for production, fueling, and transportation systems.
iGenerationLanguage‐Teacher Education: Post‐Truth Pedagogies for Decolonizing Our Professional Selves
Authors: Kouritzin Sandra
Published: June 2018

The profession and path of ELT begins with teacher education. In this entry, I first argue that rather than merely perpetuating the traditional knowledge of language teacher education, language‐teacher educators must take the profile of iGeneration pre‐service teachers (our students) and their students into account. Constantly beset with news and information on their smartphones, members of the iGeneration lack strategies for judging sources that report truth from those that peddle truthiness. I then speak to the concerns raised for students in the post‐truth present who must master distinguishing between news and fake news, while also struggling to learn English as a second language. I conclude with a call for post‐truth pedagogy, outlining what it needs to look like to combat post‐truth posturing.
Independent Control over Multiple Cell Types in Space and Time Using Orthogonal Blue and Red Light Switchable Cell Interactions
Authors: Yüz Simge G. , Ricken Julia , Wegner Seraphine V.
Published: June 2018

Independent control over multiple cell–material interactions with high spatiotemporal resolution is a key for many biomedical applications and understanding cell biology, as different cell types can perform different tasks in a multicellular context. In this study, the binding of two different cell types to materials is orthogonally controlled with blue and red light providing independent regulation in space and time. Cells expressing the photoswitchable protein cryptochrome 2 (CRY2) on cell surface bind to N‐truncated CRY‐interacting basic helix–loop–helix protein 1 (CIBN)‐immobilized substrates under blue light and cells expressing the photoswitchable protein phytochrome B (PhyB ) on cell surface bind to phytochrome interaction factor 6 (PIF6)‐immobilized substrates under red light, respectively. These light‐switchable cell interactions provide orthogonal and noninvasive control using two wavelengths of visible light. Moreover, both cell–material interactions are dynamically switched on under light and reversible in the dark. The specificity of the CRY2/CIBN and PhyB/PIF6 interactions and their response to different wavelengths of light allow selectively activating the binding of one cell type with blue and the other cell type with red light in the presence of the other cell type.
A Designed TEMPO‐derivate Catalyst with Switchable Signals of EPR and Photoluminescence: Application in the Mechanism of Alcohol Oxidation
Authors: Yin Lu , Zhang Jiaxiang , Yao Jia , Li Haoran
Published: June 2018

Construction the in situ, real‐time monitoring methodology for chemical changes, especially in the mechanism of oxidation, has long been regarded as a significant and challenging concern. Herein, we designed and synthesized a TEMPO‐mediated alkynylplatinum(II) terpyridine complex with switchable activity in photoluminescence and EPR (Electron Paramagnetic Resonance) spectra. This complex of alkynylplatinum(II) terpyridine‐TEMPO [(2, 2,6,6‐tetramethylpiperidin‐1‐yl)oxyl] is paramagnetic, while the in situ formed alkynylplatinum(II) terpyridine‐TEMPOH is diamagnetic, so that concentration changes of TEMPO/ TEMPOH species were obtained successfully by photoluminescence and EPR spectra in an operando way. As a model example, we investigated the mechanism of alcohol oxidation mediated by TEMPO/ bis(acetoxy)iodo]benzene (BAIB). It was found that, with the consumption of co‐oxidant (BAIB), the concentration and conformation of catalyst (TEMPO) were changed gradually, and the vital role of catalyst and co‐oxidant in the benzyl alcohol oxidation was clearly showed by photoluminescence and EPR spectroscopies. On the basis of these observations, we suggested an effective methodology to study the mechanism of chemical reaction, which is promising for further practical applications in analytical or environmental issues.
Design and Fabrication of TiO2/Lignocellulosic Carbon Materials: Relevance of Low‐temperature Sonocrystallization to Photocatalysts Performance
Authors: Lisowski Pawel , Colmenares Juan Carlos , Mašek Ondřej , Lisowski Wojciech , Lisovytskiy Dmytro , Grzonka Justyna , Kurzydłowski Krzysztof
Published: June 2018

We present a facile and green approach to produce crystalline TiO2 nanoparticles on a surface of different carbonaceous materials derived from lignocellulosic biomass such as STARBON‐800® obtained by carbonization at 800 °C and biochar‐SWP700 (Soft Wood Pellets (SWP) obtained by pyrolysis at 700 °C) via novel low‐temperature ultrasound‐promoted green methodology coupled with citric acid as a cross‐linking agent. In comparison to other methods, the developed method has several significant benefits such as simplicity, great ability to get crystalline TiO2 particles (elimination of high‐temperature treatment (material calcination at >300 °C) needed in the conventional sol‐gel method, which is extremely important in transforming amorphous TiO2 into a photoactive crystalline phase) elimination of risky chemicals and oxidizing agent, and also ability to change some parameters (e. g. ultrasound intensity). Prepared materials were characterized by XRD, DR UV−vis, N2 physisorption, HR‐XPS, XRF, HR‐TEM, FT‐IR and subsequently tested for their photocatalytic activities both in photocatalytic phenol degradation (in water) and oxidation of methanol (in air) under UV and visible light irradiation.
Fingerprint Stimulated Raman Scattering Imaging Reveals Retinoid Coupling Lipid Metabolism and Survival
Authors: Chen Andy J. , Li Junjie , Jannasch Amber , Mutlu Ayse Sena , Wang Meng C. , Cheng Ji‐Xin
Published: June 2018

Retinoids play critical roles in development, immunity, and lipid metabolism, and their deficiency leads to various human disorders. Yet, tools for sensing retinoids in vivo are lacking, which limits the understanding of retinoid distribution, dynamics and functions in living organisms. Here, using hyperspectral stimulated Raman scattering microscopy, we discover a previously unknown cytoplasmic store of retinoids in Caenorahbditis elegans. Following the temporal dynamics of retinoids, we reveal that their levels are positively correlated with fat storage, and their supplementation slows down fat loss during starvation. We also discover that retinoids promote fat unsaturation in response to high‐glucose stress, and improve organism survival. Together, our studies report a new method for tracking the spatiotemporal dynamics of retinoids in living organisms, and suggest the crucial roles of retinoids in maintaining metabolic homeostasis and enhancing organism fitness upon developmental and dietary stresses.
The Validity of GRE® General Test Scores for Predicting Academic Performance at U.S. Law Schools
Authors: Klieger David M. , Bridgeman Brent , Tannenbaum Richard J. , Cline Frederick A. , Olivera‐Aguilar Margarita
Published: June 2018

Educational Testing Service (ETS), working with 21 U.S. law schools, evaluated the predictive validity of the GRE® General Test using a sample of 1,587 current and graduated law students. Results indicated that the GRE is a strong, generalizably valid predictor of first‐year law school grades and that it provides useful information even when undergraduate grade point average already is available to predict those grades. This report also reviews the reliability of the GRE General Test that had been determined in prior research.
Providing high‐quality pharmaceutical care for the dying older person in hospital
Authors: Tait Paul A. , Pirone Christy , To Timothy Hong Man
Published: June 2018

Healthcare professionals working in hospitals are likely to care for people in their last year of life. Many of these people will be older, frail and at high risk of adverse events. The management of medicines forms a large part of the care of this population. The interdisciplinary healthcare team can identify patients who are near the end of their life and, in partnership with the patient (or substitute decision maker) and family, plan to achieve their goals of care. Pharmacists can contribute to quality outcomes through their specialist knowledge of the unique medication issues at the end of life. This is particularly important in the context of the frail older person with comorbidities that may complicate medication management. Effective medication management and team collaboration can relieve suffering and bring comfort to the dying patient and their family. This article outlines considerations for hospital‐based clinicians treating the older person approaching the end of their life.
Building Disciplinary Language and Literacy in Elementary Teacher Training
Authors: Siffrinn Nicole E. , Lew Shim
Published: June 2018

Given increased attention to disciplinary literacy in K–5 contexts, there is a need to explore how elementary preservice teachers are trained to engage in disciplinary instruction. The authors present a curriculum for fostering disciplinary language and literacy awareness in elementary teacher preparation. First, they explain how and why they support preservice teachers in critically reflecting on their language experiences. Second, the authors illustrate how they scaffold preservice teachers in moving from merely recognizing the speaking, listening, reading, and writing bound up in disciplinary practices to deconstructing and designing lessons that attend explicitly to the language of the disciplines. The authors conclude by addressing the opportunities and challenges of integrating this work into early childhood education programs.
Computation tree measurement language (CTML)
Authors: Jing Yaping , Miner Andrew S.
Published: June 2018

In this work, we present a formal language, CTML, to reason over probabilistic systems. CTML extends stochastic temporal logics in a way that it takes a real value as input and output a real value in the range of

[
0
,
∞
)

, as opposed to 0/1 values as input and output, and it can
nest
real values. This allows CTML to express a rich set of queries towards the unification of model checking and performance evaluation. In fact, CTML covers PCTL. It can express a nontrivial subset of PLTL formulas that cannot be expressed by PCTL. The significance of this result is that the overall complexity of CTML is linear, as opposed to exponential as it is with PLTL, in the size of the operators for a given formula, and polynomial in the size of a given model. Moreover, CTML can express real-valued performance queries such as: “if a system encounters a failure, what is the expected time to reach a recovery state?” that cannot be expressed by a probabilistic model checking logic, because they are “probabilistic” at most. Along with the specification language, we present a set of algorithms for the evaluation of the language and show proofs for their correctness. Additionally, we include an application example and show experimental results.
Health-Promoting Lifestyles Among Health Care Workers in a Postdisaster Area: A Cross-sectional Study
Authors: Yang Wanqiu , Sim Timothy , Cui Ke , Zhang Jun , Yang Yanchun , Ma Xiaohong
Published: June 2018

Objective

Health care workers performing rescue tasks in large-scale disaster areas are usually challenged in terms of physical and mental endurance, which can affect their lifestyles. Nevertheless, data on whether health care workers tend to adopt healthy lifestyles after disasters are limited. This paper compares the adoption of healthy lifestyle behaviors among health care workers with that among non–health care workers in a postdisaster area.

Methods

This cross-sectional observational study was conducted in August 2016. The Health-Promoting Lifestyle Profile II questionnaire was used to interview 261 health care workers and 848 non–health care workers.

Results

Results of the multivariable linear models showed that health care workers had lower physical activity levels (ß=−1.363, P<.0001), worse stress management (ß=−1.282, P<.0001), slower spiritual growth (ß=−1.228, P=.002), and poorer interpersonal relationships (ß=−0.814, P=.019) than non–health care workers. However, no significant differences were found in either nutrition (ß=−0.362, P=.319) or health responsibility (ß=−0.421, P=.283).

Conclusions

Health care workers had less healthy lifestyle behaviors, including physical activity, stress management, spiritual growth, and interpersonal relationships. Further studies are needed to develop health-improving interventions for health care workers in postdisaster areas. (Disaster Med Public Health Preparedness. 2019;13:230–235)
Synthesis and X-ray diffraction crystallographic characterization of compound 2-(α-naphtyl)-3-(α-pyridinyl)-1,3-thiazolidin-4-one
Authors: Pinto J. L. , Henao J. A. , Kouznetsov V.
Published: June 2018

Thiazolidinones present a wide range of useful applications especially in the biological aspect. Based on these facts, the compound of interest 2-(α-naphthyl)-3-(α-pyridinyl)-1,3-thiazolidine-4-one (C18H14N2OS), was synthesized via multi-component reaction with the aim of obtaining a compound that would show activity against fungi and bacteria. The synthesis of 2-(α-naphthyl)-3-(α-pyridinyl)-1,3-thiazolidine-4-one, was carried out from the respective α-aminopyridine with α-naphthylaldehyde and α-mercaptoacetic acid, under reflux in dry toluene for 8 h, obtaining a solid compound. Molecular characterization of the compound was carried out by infrared spectrometry, mass spectrometry, and nuclear magnetic resonance. The study of the crystallization and the calculation of the unit-cell constants were determined by the technique of X-ray diffraction of polycrystalline samples. It was determined that the compound crystallizes in a monoclinic system with space group P21/c [No. 14] and the constants of the unit cell a = 11.958 (3), b = 9.675 (4), c = 12.661 (4) Å, β = 96.960° (2), V = 1454.01 (Å3).
DIFFERENTIAL INEQUALITIES AND A MARTY-TYPE CRITERION FOR QUASI-NORMALITY
Authors: GRAHL JÜRGEN , MANKET TOMER , NEVO SHAHAR
Published: June 2018

We show that the family of all holomorphic functions $f$ in a domain $D$ satisfying $$\begin{eqnarray}\frac{|f^{(k)}|}{1+|f|}(z)\leq C\quad \text{for all }z\in D\end{eqnarray}$$ (where $k$ is a natural number and $C>0$) is quasi-normal. Furthermore, we give a general counterexample to show that for $\unicode[STIX]{x1D6FC}>1$ and $k\geq 2$ the condition $$\begin{eqnarray}\frac{|f^{(k)}|}{1+|f|^{\unicode[STIX]{x1D6FC}}}(z)\leq C\quad \text{for all }z\in D\end{eqnarray}$$ does not imply quasi-normality.
ON PAIRED ROOT SYSTEMS OF COXETER GROUPS
Authors: FU XIANG
Published: June 2018

This paper examines a systematic method of constructing a pair of (inter-related) root systems for arbitrary Coxeter groups from a class of nonstandard geometric representations. This method can be employed to construct generalizations of root systems for a large family of linear groups generated by involutions. We then give a characterization of Coxeter groups, among these groups, in terms of such paired root systems. Furthermore, we use this method to construct and study the paired root systems for reflection subgroups of Coxeter groups.
A review of integrated heart failure care
Authors: MacInnes Julie , Williams Liz
Published: June 2018

Aim

The aim of this integrative review is to determine the effectiveness of integrated heart failure (HF) care in terms of patient-, service- and resource-related outcomes, and to determine what model or characteristics of integrated care work best, for whom and in what contexts.

Background

Integration of health and social care services is a significant driver in the development of better and more cost-effective health and social care systems in Europe and developed countries. As high users of health and social care services, considerable attention has been paid to the care of people with long-term conditions. HF is a progressive, prevalent and disabling condition, requiring complex management involving multiple health and social care agencies.

Methods

An integrative review was conducted according to a framework by Whittemore and Knafl (2005). A literature search was undertaken using the databases: Medline, CINAHL, Embase, PsychINFO and the Cochrane Library, using key words of ‘heart failure’ OR ‘cardiac failure’ AND ‘integrated’ OR ‘multidisciplinary’ OR ‘interdisciplinary’ OR ‘multiprofessional’ OR ‘interprofessional’ OR ‘collaborative care’. Application of the inclusion and exclusion criteria resulted in 17 articles being included in the review. Articles were screened and coded for methodological quality according to a two-point criteria. Data were extracted using a template and analysed thematically.

Findings

Integrated HF care results in enhanced quality of life (QoL), and improved symptom control and self-management. Reduced admission rates, reduced length of hospital stay, improved prescribing practices and better care co-ordination are also reported. There is more limited evidence for improved efficiency although overall costs may be reduced. Although findings are highly context dependent, key features of integrated HF models are: liaison between primary and secondary care services to facilitate planned discharge, early and medium term follow-up, multidisciplinary patient education and team working including shared professional education, and the development and implementation of comprehensive care pathways.
Sport als angewandte Therapie bei Patienten mit schizophrenen Psychosen
Authors: Ewers Simon Manuel , Claussen Malte Christian
Published: June 2018

Zusammenfassung. Schizophrene Psychosen sind schwere psychische Erkrankungen, die im Vergleich zu gesunden Individuen und anderen psychiatrischen Störungen mit einer geringen Lebenserwartung einhergehen. Als Risikofaktoren für die erhöhte Mortalität werden Übergewicht und zugehörige Gesundheitsprobleme wie Diabetes mellitus, kardiovaskuläre Erkrankungen und mit Rauchen assoziierte Lungenerkrankungen genannt. Geringe körperliche Aktivität und vermehrtes sedentäres Verhalten wurden als wichtiger behavioraler Risikofaktor für kardiovaskuläre Erkrankungen bei Menschen mit Schizophrenie identifiziert. Zahlreiche Forschungsergebnisse zeigen einen positiven Einfluss von Sport sowohl auf die psychische Symptomatik als auch die körperliche Gesundheit. In den vorliegenden Studien kamen jedoch unterschiedliche Arten von angeleiteter Bewegung mit divergierender Intensität im Gruppen- oder Einzelsetting zur Anwendung. Die Deutsche Gesellschaft für Psychiatrie und Psychotherapie, Psychosomatik und Nervenheilkunde (DGPPN) empfiehlt den Einsatz von sport- und bewegungstherapeutischen Interventionen, aber es werden weitere grosse randomisiert kontrollierte Studien benötigt, um Art, Umfang und Dauer sowie die Wirkung der eingesetzten Methoden in den verschiedenen Phasen der Erkrankung zu untersuchen. Ein Ziel dabei sollte die evidenzbasierte Implementierung von spezifischen und systematischen sport- und bewegungstherapeutischen Interventionen als ergänzender Baustein neben der psychopharmakologischen und psychotherapeutischen Behandlung bei Menschen mit Schizophrenie sein.
Long intergenic non-coding RNA 00324 promotes gastric cancer cell proliferation via binding with HuR and stabilizing FAM83B expression
Authors: Zou Zigui , Ma Tianshi , He Xuezhi , Zhou Jinxing , Ma Hongwei , Xie Min , Liu Yanhua , Lu Die , Di Shihao , Zhang Zhihong
Published: June 2018

Substantial evidence shows that long non-coding RNAs (lncRNAs) participate in many biological mechanisms, and their dysregulation are also involved in the development and progression of cancers, including gastric cancer (GC). Long intergenic non-coding RNA 00324 (LINC00324), a 2115 bp ncRNA, is located on chromosome 17p13.1. The biological function and molecular mechanisms of LINC00324 in GC remains undiscovered. In this paper, we found that the expression level of LINC00324 was significantly upregulated in GC tissues compared with the corresponding normal tissues. The overexpression of LINC00324 was correlated with advanced TNM stage, larger tumor size, and lymph node metastasis as well as poor prognosis. Further experiments revealed that knockdown of LINC00324 could suppress the proliferation of GC cells. RNA transcriptome sequencing technology revealed that FAM83B may be a significant downstream target gene of LINC00324. LINC00324 could combine with the RNA-binding protein (RBP) human antigen R (HuR) and thus stabilize the expression of FAM83B. Moreover, rescue assays showed that the reduced FAM83B expression partially reversed the promotion of cell growth in GC induced by the overexpression of LINC00324. In conclusion, our study revealed that LINC00324 acted as an oncogene in tumorigenesis and progression, suggesting that it could be a new biomarker in diagnosis and prognosis of GC.
TLR9 activation via microglial glucocorticoid receptors contributes to degeneration of midbrain dopamine neurons
Authors: Maatouk Layal , Compagnion Anne-Claire , Sauvage Maria-Angeles Carrillo-de , Bemelmans Alexis-Pierre , Leclere-Turbant Sabrina , Cirotteau Vincent , Tohme Mira , Beke Allen , Trichet Michaël , Bazin Virginie , Trawick Bobby N. , Ransohoff Richard M. , Tronche François , Manoury Bénédicte , Vyas Sheela
Published: June 2018

Inflammation is a characteristic feature of Parkinson’s disease (PD). We examined the role of TLR9 and its regulation by glucocorticoid receptors (GRs) in degeneration of substantia nigra dopamine neurons (DNs). TLR9 agonist, CpG-ODN, induced DN degeneration in mice lacking GR in microglia but not in controls. TLR9 deletion reduced DN loss in neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of PD. GR regulates TLR9 activation during MPTP neurotoxicity as TLR9 antagonist suppressed increased DN loss in microglia/macrophage GR mutant mice. GR absence in microglia enhanced TLR9 translocation to endolysosomes and facilitated its cleavage leading to pro-inflammatory gene expression. GR-dependent TLR9 activation also triggered DN loss following intranigral injection of mitochondrial DNA. Finally, microglial GR sensitivity to A53T-alpha-synuclein induced DN degeneration as well as decreased microglial GR expression observed in SN of PD brain samples, all suggest that reduced microglial GR activity in SN can stimulate TLR9 activation and DN loss in PD pathology.
Rational Zika vaccine design via the modulation of antigen membrane anchors in chimpanzee adenoviral vectors
Authors: López-Camacho César , Abbink Peter , Larocca Rafael A. , Dejnirattisai Wanwisa , Boyd Michael , Badamchi-Zadeh Alex , Wallace Zoë R. , Doig Jennifer , Velazquez Ricardo Sanchez , Neto Roberto Dias Lins , Coelho Danilo F. , Kim Young Chan , Donald Claire L. , Owsianka Ania , De Lorenzo Giuditta , Kohl Alain , Gilbert Sarah C. , Dorrell Lucy , Mongkolsapaya Juthathip , Patel Arvind H. , Screaton Gavin R. , Barouch Dan H. , Hill Adrian V. S. , Reyes-Sandoval Arturo
Published: June 2018

Zika virus (ZIKV) emerged on a global scale and no licensed vaccine ensures long-lasting anti-ZIKV immunity. Here we report the design and comparative evaluation of four replication-deficient chimpanzee adenoviral (ChAdOx1) ZIKV vaccine candidates comprising the addition or deletion of precursor membrane (prM) and envelope, with or without its transmembrane domain (TM). A single, non-adjuvanted vaccination of ChAdOx1 ZIKV vaccines elicits suitable levels of protective responses in mice challenged with ZIKV. ChAdOx1 prME ∆TM encoding prM and envelope without TM provides 100% protection, as well as long-lasting anti-envelope immune responses and no evidence of in vitro antibody-dependent enhancement to dengue virus. Deletion of prM and addition of TM reduces protective efficacy and yields lower anti-envelope responses. Our finding that immunity against ZIKV can be enhanced by modulating antigen membrane anchoring highlights important parameters in the design of viral vectored ZIKV vaccines to support further clinical assessments.
Exploring the resilience of wheat crops grown in short rotations through minimising the build-up of an important soil-borne fungal pathogen
Authors: McMillan V. E. , Canning G. , Moughan J. , White R. P. , Gutteridge R. J. , Hammond-Kosack K. E.
Published: June 2018

Given the increasing demand for wheat which is forecast, cropping of wheat in short rotations will likely remain a common practice. However, in temperate wheat growing regions the soil-borne fungal pathogen Gaeumannomyces tritici becomes a major constraint on productivity. In cultivar rotation field experiments on the Rothamsted Farm (Hertfordshire, UK) we demonstrated a substantial reduction in take-all disease and grain yield increases of up to 2.4 tonnes/ha when a low take-all inoculum building wheat cultivar was grown in the first year of wheat cropping. Phenotyping of 71 modern elite wheat cultivars for the take-all inoculum build-up trait across six diverse trial sites identified a few cultivars which exhibited a consistent lowering of take-all inoculum build-up. However, there was also evidence of a significant interaction effect between trial site and cultivar when a pooled Residual Maximum Likelihood (REML) procedure was conducted. There was no evidence of an unusual rooting phenotype associated with take-all inoculum build-up in two independent field experiments and a sand column experiment. Together our results highlight the complex interactions between wheat genotype, environmental conditions and take-all inoculum build-up. Further work is required to determine the underlying genetic and mechanistic basis of this important phenomenon.
Lattice Boltzmann modeling to explain volcano acoustic source
Authors: Brogi Federico , Ripepe Maurizio , Bonadonna Costanza
Published: June 2018

Acoustic pressure is largely used to monitor explosive activity at volcanoes and has become one of the most promising technique to monitor volcanoes also at large scale. However, no clear relation between the fluid dynamics of explosive eruptions and the associated acoustic signals has yet been defined. Linear acoustic has been applied to derive source parameters in the case of strong explosive eruptions which are well-known to be driven by large overpressure of the magmatic fluids. Asymmetric acoustic waveforms are generally considered as the evidence for supersonic explosive dynamics also for small explosive regimes. We have used Lattice-Boltzmann modeling of the eruptive fluid dynamics to analyse the acoustic wavefield produced by different flow regimes. We demonstrate that acoustic waveform well reproduces the flow dynamics of a subsonic fluid injection related to discrete explosive events. Different volumetric flow rate, at low-Mach regimes, can explain both the observed symmetric and asymmetric waveform. Hence, asymmetric waveforms are not necessarily related to the shock/supersonic fluid dynamics of the source. As a result, we highlight an ambiguity in the general interpretation of volcano acoustic signals for the retrieval of key eruption source parameters, necessary for a reliable volcanic hazard assessment.
Effect of Biomolecules on the Nanostructure and Nanomechanical Property of Calcium-Silicate-Hydrate
Authors: Kamali Mahsa , Ghahremaninezhad Ali
Published: June 2018

Inspired by nature, this paper investigates the effect of biomolecules, such as amino acids and proteins, on the nanostructure and mechanical stiffness of calcium-silicate-hydrate (C-S-H). Amino acids with distinct functional groups, and proteins with different structures and compositions were used in the synthesis of the C-S-H nanocomposite. The atomic structure was examined using X-ray diffraction (XRD) and Fourier transform infrared spectroscopy (FTIR). The morphology was investigated using scanning electron microscopy (SEM) and atomic force microscopy (AFM). AFM nanoindentation was used to evaluate the Young’s modulus of the modified C-S-H. Positively charged, H-bond forming and hydrophobic amino acids were shown to influence the atomic structure of C-S-H. The effect of negatively charged amino acid on atomic structure was more pronounced at higher C/S ratio. A noticeable increase in silicate polymerization of C-S-H modified with proteins at high C/S ratio was observed. The microscopic examination demonstrated a globular morphology for all samples except for C-S-H modified with hemoglobin, which showed a platelet morphology. The Young’s modulus of C-S-H with amino acids and proteins showed a general reduction compared to that of the control C-S-H.
Communicative mind-reading in preverbal infants
Authors: Tauzin Tibor , Gergely György
Published: June 2018

Pragmatic theories of communication assume that humans evolved a species-unique inferential capacity to express and recognize intentions via communicative actions. We show that 13-month-old non-verbal infants can interpret the turn-taking exchange of variable tone sequences between unfamiliar agents as indicative of communicative transfer of goal-relevant information from a knowledgeable to a naïve agent pursuing the goal. No such inference of information transfer was drawn by the infants, however, when a) the agents exchanged fully predictable identical signal sequences, which does not enable transmission of new information, or b) when no goal-relevant contextual change was observed that would motivate its communicative transmission. These results demonstrate that young infants can recognize communicative interactions between third-party agents and possess an evolved capacity for communicative mind-reading that enables them to infer what contextually relevant information has been transmitted between the agents even without language.
Defibrinogen Therapy for Acute Ischemic Stroke: 1332 Consecutive Cases
Authors: Chen Jing , Sun Dalong , Liu Mingli , Zhang Shufan , Ren Chuancheng
Published: June 2018

This study aimed to examine the effectiveness of defibrinogen therapy on functional recovery and safety among 1332 consecutive ischemic stroke patients who had not received intravenous thrombolysis with recombinant tissue plasminogen activator. Stroke patients undergoing conservative and relatively individualized multiple-day dosing regimens of defibrinogen therapy between January 1, 2008 and May 30, 2016 were enrolled. Data were analyzed according to functional success (Barthel Index of 95 or 100, mRS of 0 or 1) and safety variables (intracranial hemorrhage, mortality and stroke recurrence). At 12 months, 18.62% (203/1087) of patients were lost to follow-up. The functional success rates were 39.84% (526/1320) and 42.23% (459/1087) as assessed by BI at 3 months and 12 months, respectively. Fifteen patients had asymptomatic intracranial hemorrhage within 24 hours after the initial defibrase administration. During the 14 days after hospitalization, 12 patients were diagnosed with symptomatic intracranial hemorrhage (sICH) and a total of 12 patients died from all causes. At 3 months, 56 patients were dead and 21 patients had recurrent stroke. The percentage of death and recurrence of stroke at 12 months were 6.81% and 3.22%, respectively. Results from the historical control showed no significant differences of functional success were detected between the patients treated with rt-PA within 6 hours of stroke onset in NINDS II and the patients treated with defibrase within 6 hours after stroke in the present study. The multiple-day dosing regimen of defibrinogen therapy using defibrase applied in the present study could achieve functional improvement among acute ischemic stroke patients, with low risks of mortality when compared with other similar studies. However, the efficacy and safety of such a defibrinogenating therapy is needed to be verified by RCTs with large sample size.
Amygdala enlargement and emotional responses in (autoimmune) temporal lobe epilepsy
Authors: Holtmann Olga , Schlossmacher Insa , Moenig Constanze , Johnen Andreas , Rutter Lisa-Marie , Tenberge Jan-Gerd , Schiffler Patrick , Everding Judith , Golombeck Kristin S. , Strippel Christine , Dik Andre , Schwindt Wolfram , Wiendl Heinz , Meuth Sven G. , Bruchmann Maximilian , Melzer Nico , Straube Thomas
Published: June 2018

Temporal lobe epilepsy with amygdala enlargement (TLE-AE) is increasingly recognized as a distinct adult electroclinical syndrome. However, functional consequences of morphological alterations of the amygdala in TLE-AE are poorly understood. Here, two emotional stimulation designs were employed to investigate subjective emotional rating and skin conductance responses in a sample of treatment-naïve patients with suspected or confirmed autoimmune TLE-AE (n = 12) in comparison to a healthy control group (n = 16). A subgroup of patients completed follow-up measurements after treatment. As compared to healthy controls, patients with suspected or confirmed autoimmune TLE-AE showed markedly attenuated skin conductance responses and arousal ratings, especially pronounced for anxiety-inducing stimuli. The degree of right amygdala enlargement was significantly correlated with the degree of autonomic arousal attenuation. Furthermore, a decline of amygdala enlargement following prompt aggressive immunotherapy in one patient suffering from severe confirmed autoimmune TLE-AE with a very recent clinical onset was accompanied by a significant improvement of autonomic responses. Findings suggest dual impairments of autonomic and cognitive discrimination of stimulus arousal as hallmarks of emotional processing in TLE-AE. Emotional responses might, at least partially, recover after successful treatment, as implied by first single case data.
Light extraction from fundamental modes in modulated waveguides for homogeneous side-emission
Authors: Pan Zhiwen , Wondraczek Lothar
Published: June 2018

Dedicated control of axial light emission from light-guides enables a new generation of functional light sources for volumetric illumination. A primary challenge is to ensure homogeneous emission intensity across the full length of the device. Here, we introduce an approach towards homogeneously side-emitting waveguides which do not rely on imposing local scattering centers such as bubbles, micro-/nanoparticles, and rough or abrupt interfaces, but on modulated core radius. Previous quantitative studies of the relationship between structural parameters and radiation losses provide initial conditions for tailoring side-emission through core-diameter modulations, however, with strongly limited amplitude of modulation. We now employ and verify numerical simulation to overcome this limitation towards meter-long homogeneously side-emitting waveguides in which the amplitude of core-diameter modulation is of the same order of magnitude as the core diameter itself. Similar emission properties can be obtained through modulation of the core refractive index instead of the core diameter, or through a combination of both approaches. Using the present model, we deduce exemplary conditions for homogeneous side-emission in which the power flow within the waveguides decays linearly, what may present another interesting feature for applications beyond illumination.
Atlantic Niño modulation of the Indian summer monsoon through Asian jet
Authors: Yadav Ramesh Kumar , Srinivas G. , Chowdary Jasti S.
Published: June 2018

The Indian rainfall and the Atlantic Niño peaks during summer month and have inverse relationship. This relationship has been revisited in the current study and it is found that the Atlantic Niño significantly influences a dipole pattern of rainfall in the north–east and the north-western parts of India. The positive phase of the Atlantic Niño intensifies the inter-tropical convergence zone, as a result of this local tropospheric warming, over the equatorial east Atlantic and west Africa, owing to the enlargement of the upper-troposphere divergence. This provokes meridional stationary wave owing to the stronger meridional transfer of energy, as the influences of background jet-streams are minimal over North Africa and Europe. This results in the consecutive anomalous negative, positive, and negative geopotential heights (GPHs) over the tropical east Atlantic, Mediterranean, and north–west Europe, respectively. The north–west Europe acts as the center of action for the propagation of a Rossby wave train zonally oriented toward central Asia reinforcing positive GPH anomaly over there. The positive GPH anomaly reduces the Asian subtropical westerly jet-stream east of the Caspian Sea, owing to the reduction in the upper-troposphere divergence toward the Indian subcontinent and caused for above (below) normal north–east (north–west) Indian summer monsoon rainfall. The atmospheric general circulation model captures general characteristics of wave pattern and changes in the Asian jet when correlated with Atlantic Niño with considerable skill.
p-TsOH promoted synthesis of benzo-fused O-heterocycles from alkynolsviaring contraction and C–O scission strategy
Authors: Senadi Gopal Chandru , Wang Jeh-Jeng
Published: June 2018

Here, we report the first divergent synthesis of benzo-fused O-heterocycles byp-toluene sulfonic acid promoted cascade reactions involving alkyne hydration, double cyclization, ring contraction and C–O bond cleavage from alkynols.
Effect of electrode material and electrolysis process on the preparation of electrolyzed oxidizing water
Authors: Ming Ruoxi , Zhu Yuchan , Deng Li , Zhang Ailian , Wang Ju , Han Yongqi , Chai Bo , Ren Zhandong
Published: June 2018

The efficient preparation of EO water can be controlled by different electrode materials and electrolysis processes.
Gravimetric, electrochemical and surface studies on the anticorrosive properties of 1-(2-pyridyl)-2-thiourea and 2-(imidazol-2-yl)-pyridine for mild steel in hydrochloric acid
Authors: Zhang Weiwei , Li Hui-Jing , Wang Yiwei , Liu Ying , Gu Qing-Ze , Wu Yan-Chao
Published: June 2018

1-(2-Pyridyl)-2-thiourea and 2-(imidazol-2-yl)-pyridine are described here for the first time as inhibitors of mild steel corrosion in acidic medium.
Fe2Mo3O8/exfoliated graphene oxide: solid-state synthesis, characterization and anodic application in Li-ion batteries
Authors: Maseed Hussen , Petnikota Shaikshavali , Srikanth Vadali V. S. S. , Srinivasan Madhavi , B. V. R. Chowdari , Reddy M. V. , Adams Stefan
Published: June 2018

An Fe2Mo3O8/exfoliated graphene oxide (EG) composite with unique morphology is synthesized by a novel solid-state reduction method.
An electron compensation mechanism for the polymorphism of boron monolayers
Authors: Xu Shao-Gang , Li Xiao-Tian , Zhao Yu-Jun , Liao Ji-Hai , Xu Hu , Yang Xiao-Bao
Published: June 2018

Boron monolayers have been increasingly attractive, while it is still a challenge to understand their structural stabilities, due to electron deficiency and multi-center bonds.
Synthesis of a functionalized multi-walled carbon nanotube decorated ruskin michelle-like ZnO nanocomposite and its application in the development of a highly sensitive hydroquinone sensor
Authors: Balram Deepak , Lian Kuang-Yow , Sebastian Neethu
Published: June 2018

Electrochemical determination of hydroquinone based on a f-MWCNT decorated ruskin michelle-like ZnO nanocomposite.