bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of iron overload from multi walled carbon nanotubes on neutrophil-like differentiated HL-60 cells
Authors: Tabei Yosuke , Fukui Hiroko , Nishioka Ayako , Hagiwara Yuji , Sato Kei , Yoneda Tadashi , Koyama Tamami , Horie Masanori
Published: February 2019

Multi walled carbon nanotubes (MWCNTs) are one of the most intensively explored nanomaterials because of their unique physical and chemical properties. Due to the widespread use of MWCNTs, it is important to investigate their effects on human health. The precise mechanism of MWCNT toxicity has not been fully elucidated. The present study was designed to examine the mechanisms of MWCNT toxicity toward human promyelocytic leukemia HL-60 cells. First, we found that MWCNTs decreased the viability of neutrophil-like differentiated HL-60 cells but not undifferentiated HL-60 cells. Because neutrophil-like differentiated HL-60 cells exhibit enhanced phagocytic activity, the cytotoxicity of MWCNTs is dependent on the intracellularly localized MWCNTs. Next, we revealed that the cytotoxicity of MWCNTs is correlated with the intracellular accumulation of iron that is released from the engulfed MWCNTs in an acidic lysosomal environment. The intracellular accumulation of iron was repressed by treatment with cytochalasin D, a phagocytosis inhibitor. In addition, our results indicated that iron overload enhanced the release of interleukin-8 (IL-8), a chemokine that activates neutrophils, and subsequently elevated intracellular calcium concentration ([Ca2+]i). Finally, we found that the sustained [Ca2+]ielevation resulted in the loss of mitochondrial membrane potential and the increase of caspase-3 activity, thereby inducing apoptotic cell death. These findings suggest that the iron overload caused by engulfed MWCNTs results in the increase of IL-8 production and the elevation of [Ca2+]i, thereby activating the mitochondria-mediated apoptotic pathway.
Aurora A controls CD8+ T cell cytotoxic activity and antiviral response
Authors: Bustos-Morán Eugenio , Blas-Rus Noelia , Alcaraz-Serna Ana , Iborra Salvador , González-Martínez José , Malumbres Marcos , Sánchez-Madrid Francisco
Published: February 2019

Aurora A is a serine/threonine kinase whose role in cell cycle progression and tumour generation has been widely studied. Recent work has revealed an unexpected function for Aurora A during CD4+ T cell activation and, also, in graft versus host disease development. However, it remains unknown whether Aurora A is involved in CD8+ T cell effector function and in cytotoxic T lymphocyte-mediated antiviral response. Here, we show that Aurora A chemical inhibition leads to an impairment of both the peptide-specific cytotoxicity and the degranulation activity of CD8+ T cells. This finding was similarly proven for both mice and human CD8+ CTL activity. As a result of Aurora A blockade, we detected a reduction in the expression induced by T cell activation of genes classically related to the effector function of cytotoxic T lymphocytes such as granzyme B or perforin1. Finally, we have found that Aurora A is necessary for CD8+ T cell-mediated antiviral response, in an in vivo model of vaccinia virus infection. Thus, we can conclude that Aurora A activity is, indeed, needed for the proper effector function of cytotoxic T lymphocytes and for their activity against viral threats.
Delayed Captopril Administration Mitigates Hematopoietic Injury in a Murine Model of Total Body Irradiation
Authors: McCart Elizabeth A. , Lee Young H. , Jha Jyoti , Mungunsukh Ognoon , Rittase W. Bradley , Summers Thomas A. , Muir Jeannie , Day Regina M.
Published: February 2019

The increasing potential for accidental radiation exposure from either nuclear accidents or terrorist activities has escalated the need for radiation countermeasure development. We previously showed that a 30-day course of high-dose captopril, an ACE inhibitor, initiated 1–4 h after total body irradiation (TBI), improved Hematopoietic Acute Radiation Syndrome (H-ARS) and increased survival in mice. However, because of the time likely required for the deployment of a stockpiled radiation countermeasure to a radiation mass casualty site, there is a need for therapies that can be administered 24–48 hours after initial exposure. Using C57BL/6 mice exposed to an LD50-80/30 of 60Co TBI (7.75–7.9 Gy, 0.615 Gy/min), we show that low-dose captopril administration, initiated as late as 48 h post-TBI and continued for 14 days, significantly enhanced overall survival similarly to high-dose, rapid administration. Captopril treatment did not affect radiation-induced cell cycle arrest genes or the immediate loss of hematopoietic precursors. Reduced mortality was associated with the recovery of bone marrow cellularity and mature blood cell recovery at 21–30 days post-irradiation. Captopril reduced radiation-induced cytokines EPO, G-CSF, and SAA in the plasma. Finally, delayed captopril administration mitigated brain micro-hemorrhage at 21 days post-irradiation. These data indicate that low dose captopril administered as late as 48 h post-TBI for only two weeks improves survival that is associated with hematopoietic recovery and reduced inflammatory response. These data suggest that captopril may be an ideal countermeasure to mitigate H-ARS following accidental radiation exposure.
A decision-support framework to optimize border control for global outbreak mitigation
Authors: Zlojutro Aleksa , Rey David , Gardner Lauren
Published: February 2019

The introduction and spread of emerging infectious diseases is increasing in both prevalence and scale. Whether naturally, accidentally or maliciously introduced, the substantial uncertainty surrounding the emergence of novel viruses, specifically where they may come from and how they will spread, demands robust and quantifiably validated outbreak control policies that can be implemented in real time. This work presents a novel mathematical modeling framework that integrates both outbreak dynamics and outbreak control into a decision support tool for mitigating infectious disease pandemics that spread through passenger air travel. An ensemble of border control strategies that exploit properties of the air traffic network structure and expected outbreak behavior are proposed. A stochastic metapopulation epidemic model is developed to evaluate and rank the control strategies based on their effectiveness in reducing the spread of outbreaks. Sensitivity analyses are conducted to illustrate the robustness of the proposed control strategies across a range of outbreak scenarios, and a case study is presented for the 2009 H1N1 influenza pandemic. This study highlights the importance of strategically allocating outbreak control resources, and the results can be used to identify the most robust border control policy that can be implemented in the early stages of an outbreak.
On-chip combined radiotherapy and chemotherapy testing on soft-tissue sarcoma spheroids to study cell death using flow cytometry and clonogenic assay
Authors: Patra Bishnubrata , Lafontaine Julie , Bavoux Maeva , Zerouali Karim , Glory Audrey , Ahanj Mohsen , Carrier Jean-François , Gervais Thomas , Wong Philip
Published: February 2019

Radiotherapy (RT) and chemotherapy (CT) are the major therapeutics to treat cancer patients. Conventional in vitro 2D models are insufficient to study the combined effects of RT and CT towards optimized dose selection or drug screening. Soft-tissue sarcomas (STS) are rare cancers with profound social impacts as they affect patients of all ages. We developed a microfluidic device to form and culture STS spheroids to study the combined cytotoxicities of RT and CT. Uniformly-sized spheroids of two different cell lines, STS 93 and STS 117, were formed in the device. RT doses of 0.5 Gy, 2 Gy, and 8 Gy were used in combination with CT, doxorubicin at 2 µM and 20 µM. The spheroids culture chambers within the device were arranged in a 3 × 5 matrix form. The device was made “peelable”, which enabled us to collect spheroids from each treatment condition separately. Collected spheroids were dissociated into single cells and evaluated using flow cytometry and clonogenic assays. Through this workflow, we observed that STS 93 spheroids treated with doxorubicin die through apoptosis, whereas RT induced death through other pathways. Spheroids from the p53 mutant STS 117 cell line were more resistant to RT and doxorubicin. The developed device could be used for the discovery of new drugs and RT synergies.
Identification of FDA-approved drugs targeting the Farnesoid X Receptor
Authors: van de Wiel Sandra M. W. , Bijsmans Ingrid T. G. W. , van Mil Saskia W. C. , van de Graaf Stan F. J.
Published: February 2019

The farnesoid X receptor (FXR) belongs to the nuclear receptor family and is activated by bile acids. Multiple, chemically rather diverse, FXR agonists have been developed and several of these compounds are currently tested in clinical trials for NAFLD and cholestasis. Here, we investigated possible FXR-agonism or antagonism of existing FDA/EMA-approved drugs. By using our recently developed FRET-sensor, containing the ligand binding domain of FXR (FXR-LBD), 1280 FDA-approved drugs were screened for their ability to activate FXR in living cells using flow cytometry. Fifteen compounds induced the sensor for more than twenty percent above background. Real-time confocal microscopy confirmed that avermectin B1a, gliquidone, nicardipine, bepridil and triclosan activated the FRET sensor within two minutes. These compounds, including fluticasone, increased mRNA expression of FXR target genesOSTαandOSTβin Huh7 cells, and in most cases also ofMRP2,SHPandFGF19. Finally, avermectin B1a, gliquidone, nicardipine and bepridil significantly increased IBABP promoter activity in a luciferase reporter assay in a dose-dependent manner. In conclusion, six FDA/EMA-approved drugs currently used in the clinical practice exhibit moderate agonistic FXR activity. This may on the one hand explain (undesired) side-effects, but on the other hand may form an opportunity for polypharmacology.
Quantitative Analysis of CT Images in Patients with Pyrrolizidine Alkaloid-Induced Sinusoidal Obstruction Syndrome
Authors: Wang Chao , Wu Xingwang , Xie Wentao , Ren Xiaofei , Zhang Weiping , Xu Jianming
Published: February 2019

This study evaluated hepatic lesion volumes on contrast-enhanced computed tomography (CT) images in patients with pyrrolizidine alkaloid-induced sinusoidal obstruction syndrome (PA-SOS) and the association of lesion volume with the clinical severity and prognosis of the disease. Twenty-five patients with PA-SOS were included in this study, and all patients were subjected to a complete CT imaging series. The imaging results were quantitatively analyzed by a threshold-based region growing algorithm. The liver volumes and hepatic lesion volumes of the patients were estimated. Based on clinical presentations, PA-SOS was classified into three categories: mild, moderate and severe. The associations of hepatic lesion volumes with liver function test parameters and the clinical severity and prognosis of the disease were analyzed. Based on estimations using the threshold-based region growing algorithm, hepatic lesion volumes in patients with mild PA-SOS were significantly lower than those in patients with moderate and severe PA-SOS (P < 0.05). The ratio of hepatic lesion volume to liver volume (Ratio) varied based on alanine aminotransferase (ALT), aspartate aminotransferase (AST) and serum total bilirubine levels; clinical severity; and disease prognosis, and the differences were statistically significant (P < 0.05). In conclusion, the threshold-based region growing algorithm can be employed to quantitatively analyze enhanced CT images of PA-SOS patients. And the ratio of hepatic lesion volume to liver volume in patients with PA-SOS is associated with a more serious clinical course and a poorer outcome.
Prevalence and serological profile of anti-DFS70 positive subjects from a routine ANA cohort
Authors: Carbone Teresa , Pafundi Vito , Tramontano Giuseppina , Gilio Michele , Padula Maria Carmela , Padula Angela Anna , D’Angelo Salvatore
Published: February 2019

Anti-Dense Fine Speckled 70 (DFS70) antibodies are a common finding in clinical laboratory referrals. High prevalence of DFS70 autoantibodies in healthy population and usual negative association with Antinuclear Antibody (ANA)-associated autoimmune rheumatic diseases (AARD) were reported. The aim of this study was to evaluate the prevalence of DFS70 autoantibodies and their association with other autoantibodies in the context of a routine ANA referral cohort. Consecutive sera submitted for ANA screening were analyzed for anti-DFS70 antibodies by indirect immunofluorescence (IIF) (n = 3175, 1030 men and 2145 women) then confirmed by immunoblotting. Anti-DFS70 positive samples were also assayed for a large spectrum of other circulating autoantibodies. The prevalence of anti-DFS70 antibodies was 1.7% in the whole population and 4.6% in the ANA-positive samples. Comparison between DFS70 IIF and immunoblotting showed an excellent correlation between the two methods. The prevalence of anti-DFS70 positive was significantly higher in females (2.1%, 45/2145) than in males (1.0%, 10/1030). Of note, no concomitant autoantibodies were found in the DFS70-positive male group compared with DFS70-positive females group that showed other serum autoantibodies in the 51% of cases. Anti-DFS70 reactivity in male population may represent an useful biomarker predicting the absence of other autoantibodies. On the contrary, the serological profile of DFS70-positive females required further investigations in order to define the presence of concomitant disease-marker autoantibodies.
Urinary proteome signature of Renal Cysts and Diabetes syndrome in children
Authors: Ricci Pierbruno , Magalhães Pedro , Krochmal Magdalena , Pejchinovski Martin , Daina Erica , Caruso Maria Rosa , Goea Laura , Belczacka Iwona , Remuzzi Giuseppe , Umbhauer Muriel , Drube Jens , Pape Lars , Mischak Harald , Decramer Stéphane , Schaefer Franz , Schanstra Joost P. , Cereghini Silvia , Zürbig Petra
Published: February 2019

Renal Cysts and Diabetes Syndrome (RCAD) is an autosomal dominant disorder caused by mutations in the HNF1B gene encoding for the transcriptional factor hepatocyte nuclear factor-1B. RCAD is characterized as a multi-organ disease, with a broad spectrum of symptoms including kidney abnormalities (renal cysts, renal hypodysplasia, single kidney, horseshoe kidneys, hydronephrosis), early-onset diabetes mellitus, abnormal liver function, pancreatic hypoplasia and genital tract malformations. In the present study, using capillary electrophoresis coupled to mass spectrometry (CE-MS), we investigated the urinary proteome of a pediatric cohort of RCAD patients and different controls to identify peptide biomarkers and obtain further insights into the pathophysiology of this disorder. As a result, 146 peptides were found to be associated with RCAD in 22 pediatric patients when compared to 22 healthy age-matched controls. A classifier based on these peptides was generated and further tested on an independent cohort, clearly discriminating RCAD patients from different groups of controls. This study demonstrates that the urinary proteome of pediatric RCAD patients differs from autosomal dominant polycystic kidney disease (PKD1, PKD2), congenital nephrotic syndrome (NPHS1, NPHS2, NPHS4, NPHS9) as well as from chronic kidney disease conditions, suggesting differences between the pathophysiology behind these disorders.
Recombination analysis of Human mastadenovirus C whole genomes
Authors: Rivailler Pierre , Mao Naiying , Zhu Zhen , Xu Wenbo
Published: February 2019

This study aims at analyzing all publicly available HAdV-C whole genome sequences (WGSs) and describes the genetic relationships between these genomes as well as identifies potential hotspots for recombination throughout the viral genome. In addition to the 4 prototypical genomic sequences, this analysis identified 20 HAdV-C WGSs which should be relevant for future recombination analysis of HAdV-C. This report confirmed the recombinogenic property of HAdV-C genomes and identified two main regions for breakpoints, within the hexon gene and around the fiber genomic region. No obvious recombination was detected between HAdV-Cs and non-human mastadenoviruses or non-C HAdVs. Finally, it highlighted the need for a surveillance of HAdVs in order to detect novel recombinant types that might represent health risks and develop possible prevention measures. Genetic analyses of recombination between recently collected HAdV-Cs and the assessment of their potential virulence are necessary steps towards the establishment of a surveillance of HAdVs in the future.
Environmental Toxicant Induced Epigenetic Transgenerational Inheritance of Prostate Pathology and Stromal-Epithelial Cell Epigenome and Transcriptome Alterations: Ancestral Origins of Prostate Disease
Authors: Klukovich Rachel , Nilsson Eric , Sadler-Riggleman Ingrid , Beck Daniel , Xie Yeming , Yan Wei , Skinner Michael K.
Published: February 2019

Prostate diseases include prostate cancer, which is the second most common male neoplasia, and benign prostatic hyperplasia (BPH), which affects approximately 50% of men. The incidence of prostate disease is increasing, and some of this increase may be attributable to ancestral exposure to environmental toxicants and epigenetic transgenerational inheritance mechanisms. The goal of the current study was to determine the effects that exposure of gestating female rats to vinclozolin has on the epigenetic transgenerational inheritance of prostate disease, and to characterize by what molecular epigenetic mechanisms this has occurred. Gestating female rats (F0 generation) were exposed to vinclozolin during E8-E14 of gestation. F1 generation offspring were bred to produce the F2 generation, which were bred to produce the transgenerational F3 generation. The transgenerational F3 generation vinclozolin lineage males at 12 months of age had an increased incidence of prostate histopathology and abnormalities compared to the control lineage. Ventral prostate epithelial and stromal cells were isolated from F3 generation 20-day old rats, prior to the onset of pathology, and used to obtain DNA and RNA for analysis. Results indicate that there were transgenerational changes in gene expression, noncoding RNA expression, and DNA methylation in both cell types. Our results suggest that ancestral exposure to vinclozolin at a critical period of gestation induces the epigenetic transgenerational inheritance of prostate stromal and epithelial cell changes in both the epigenome and transcriptome that ultimately lead to prostate disease susceptibility and may serve as a source of the increased incidence of prostate pathology observed in recent years.
Printed Microwave Metamaterial-Antenna Circuitries on Nickel Oxide Polymerized Palm Fiber Substrates
Authors: Elwi Taha A.
Published: February 2019

In this paper, the novelty of exploring the applications of the Iraqi Palm Tree Remnants (IPTR) mixed with Nickel Oxide Nanoparticles (NONP) hosted in Polyethylene (PE), called INP substrates, is utilized by printing metamaterial (MTM) based high gain microwave antennas on them. The proposed INP substrates are mainly created from pressed flexible organic fibers to suite the ink jet printing technologies. The complex relative constitutive parameters are characterized in terms of permittivity (ε) and permeability (μ) within the frequency range from 2 GHz up to 6 GHz using an open end dielectric probe and a T-stub transmission line technique. To validate the feasibility of the INP substrates, a very fine antenna structure of based a miniaturized Hilbert MTM based dipoles is printed on. A material printer with Sliver Nanoparticles Conductive Ink (SNPCI) is used to print the antenna structure. Commercial software packages, CST Microwave Studio (MWS) and Ansys High Frequency Structure Simulator (HFSS), are used to simulate the proposed antenna based on the measured constitutive parameters. A negligible difference is found between the measured and simulated results. Finally, an attractive effect on the retrieved constitutive parameters of the proposed MTM is found due to the proposed INP substrate.
Visual colorimetric sensing system based on the self-assembly of gold nanorods and graphene oxide for heparin detection using a polycationic polymer as a molecular probe
Authors: Bamrungsap Suwussa , Cherngsuwanwong Jarumeth , Srisurat Petpimon , Chonirat Jaruwan , Sangsing Natcha , Wiriyachaiporn Natpapas
Published: February 2019

Simple colorimetric system based on gold nanorods-graphene oxide self-assembly for heparin detection using a polycationic polymer as a molecular probe is shown here.
In-depth structural analysis of lanthanoid coordination networks based on a flexible tripodal zwitterionic isonicotinate ligand
Authors: Tiihonen Antti , Lahtinen Manu
Published: February 2019

Variety in network solids through electrostatic interactions – a thorough investigation of lanthanoid MOFs with a zwitterionic ligand.
Effects of sulfate on biotite interfacial reactions under high temperature and high CO2 pressure
Authors: Zhang Lijie , Zhu Yaguang , Wu Xuanhao , Jun Young-Shin
Published: February 2019

Anions affect water–biotite interfacial interactions to different extents and subsequently alter surface wettability.
Route towards sustainable smart sensors: ferroelectric polyvinylidene fluoride-based materials and their integration in flexible electronics
Authors: Stadlober Barbara , Zirkl Martin , Irimia-Vladu Mihai
Published: February 2019

Printed ferroelectric devices are ideal candidates for self-powered and multifunctional sensor skins, contributing to a sustainable smart future.
Effects of n-3 fatty acid supplements on cardiometabolic profiles in hypertensive patients with abdominal obesity in Inner Mongolia: a randomized controlled trial
Authors: Yang Bo , Shi Mei-qi , Li Zi-hao , Shi Lin , Wang Ai-min , Guo Xiao-juan , Li Duo
Published: February 2019

Daily supplementation with n-3 fatty acid (FA) has been believed to be an adjunct or alternative to drug treatments to reduce blood pressure (BP) and triglyceride (TG) levels in western patients with high risk of cardiovascular disease.
Dietary zerumbone from shampoo ginger: new insights into its antioxidant and anticancer activity
Authors: Rosa A. , Caprioglio D. , Isola R. , Nieddu M. , Appendino G. , Falchi A. M.
Published: February 2019

The dietary sesquiterpene dienone zerumbone (ZER) selectively targets cancer cells, inducing mitochondrial dysfunction, apoptosis, modulation of the total lipid profile, and accumulation of cytosolic lipid droplets.
Comparative antitumor studies of organoruthenium complexes with 8-hydroxyquinolines on 2D and 3D cell models of bone, lung and breast cancer
Authors: Ruiz Maria C , Kljun Jakob , Turel Iztok , Di Virgilio Ana L , León Ignacio E
Published: February 2019

The purpose of this work was to screen the antitumor actions of two metal organoruthenium-8-hydroxyquinolinato (Ru-hq) complexes to find a potential novel agent for bone, lung and breast chemotherapies. We showed that ruthenium compounds (1 and 2) impaired the cell viability of human bone (MG-63), lung (A549) and breast (MCF7) cancer cells with greater selectivity and specificity than cisplatin. Besides, complexes 1 and 2 decreased proliferation, migration and invasion on cell monolayers at lower concentrations (2.5–10 μM). In addition, both compounds induced genotoxicity revealed by the micronucleus test, which led to G2/M cell cycle arrest and induced the tumor cells to undergo apoptosis. On the other hand, in multicellular 3D models (multicellular spheroids; MCS), 1 and 2 overcame CDDP presenting lower IC50 values only in MCS of lung origin. Moreover, 1 outperformed 2 in MCS of bone and breast origin. Finally, our findings revealed that both compounds inhibited the cell invasion of multicellular spheroids, showing that complex 1 exhibited the most important antimetastatic action. Taken together, these results indicate that compound 1 is an interesting candidate to be tested on in vivo models as a novel strategy for anticancer therapy.
Structural nanotechnology: three-dimensional cryo-EM and its use in the development of nanoplatforms forin vitrocatalysis
Authors: de Ruiter Mark V. , Klem Robin , Luque Daniel , Cornelissen Jeroen J. L. M. , Castón José R.
Published: February 2019

Three-dimensional cryo-EM analysis of protein-based nanoreactors to improvein vitrocatalysis.
Dual-receptor targeted strategy in nanoparticle design achieves tumor cell selectivity through cooperativity
Authors: Stefanick Jared Francis , Omstead David Thomas , Kiziltepe Tanyel , Bilgicer Basar
Published: February 2019

Dual-targeted liposomes achieve increased uptake and selectivity for multiple myeloma cells through cooperative peptide targeting of LPAM-1 and VLA-4.
Superior-capacity binder-free anode electrode for lithium-ion batteries: CoxMnyNizO nanosheets with metal/oxygen vacancies directly formed on Cu foil
Authors: Li Qing , Feng Yuzhang , Wang Peng , Che Renchao
Published: February 2019

CoxMnyNizO (x : y : z = 8 : 0.92 : 0.71) nanosheets formed on a Cu foil (CMN-CH) are directly used as anode electrodes, demonstrating superior electrochemical performances.
Highly luminescent red emissive perovskite quantum dots-embedded composite films: ligands capping and caesium doping-controlled crystallization process
Authors: Wu Xian-gang , Tang Jialun , Jiang Feng , Zhu Xiaoxiu , Zhang Yanliang , Han Dengbao , Wang Lingxue , Zhong Haizheng
Published: February 2019

A ligand and Cs+ were introduced to reduce the solubility between precursors and polymers, resulting in highly luminescent composite films.
Controlling the 3-D morphology of Ni–Fe-based nanocatalysts for the oxygen evolution reaction
Authors: Manso Ryan H. , Acharya Prashant , Deng Shiqing , Crane Cameron C. , Reinhart Benjamin , Lee Sungsik , Tong Xiao , Nykypanchuk Dmytro , Zhu Jing , Zhu Yimei , Greenlee Lauren F. , Chen Jingyi
Published: February 2019

The 3-D morphology plays a key role in the optimization of the electrocatalytic activity and stability of nanocatalysts for the OER.
Scalable synthesis of FeS2 nanoparticles encapsulated into N-doped carbon nanosheets as a high-performance sodium-ion battery anode
Authors: Lin Zhihua , Xiong Xunhui , Fan Mengna , Xie Dong , Wang Gang , Yang Chenghao , Liu Meilin
Published: February 2019

Nanostructured FeS2 embedded in an N-doped carbon nanosheet composite (FeS2/CNS) was prepared and exhibited superior performance as a sodium-ion battery anode.
Orthogonally clickable hyperbranched polymers: effect of reactant size and polarity on core-functionalization of peripherally jacketed HBPs
Authors: Perala Suresh Kumar , Ramakrishnan S.
Published: February 2019

Using an orthogonally clickable strategy, the accessibility of internal allyl groups in jacketed HBPs, bearing either PEG or docosyl peripheral segments, was shown to depend both on the size and relative polarity of the reactant thiol.
Disassembly and tumor-targeting drug delivery of reduction-responsive degradable block copolymer nanoassemblies
Authors: Oh Jung Kwon
Published: February 2019

Review on recent strategies to synthesize novel disulfide-containing reductively-degradable block copolymers and their nanoassemblies as being classified with the number, position, and location of the disulfide linkages toward effective tumor-targeting intracellular drug delivery exhibiting enhanced release of encapsulated drugs.
Stability and pervaporation characteristics of PVA and its blend with PVAm membranes in a ternary feed mixture containing highly reactive epichlorohydrin
Authors: Chaudhari Shivshankar , Kwon YongSung , Shon MinYoung , Nam SeungEun , Park YouIn
Published: February 2019

In order to find an alternative for classical distillation in the recovery of ECH/IPA from azeotropic ECH/IPA/water (50/30/20 w/w, %) mixtures, a pervaporation process has been applied.
Green synthesis of a AgCl@AgI nanocomposite using Laminaria japonica extract and its application as a visible-light-driven photocatalyst
Authors: Ruan Zhongyu , Liu Guihong , Shu Jinxia , Ren Chunguang , Wang Zhonghua
Published: February 2019

A AgCl@AgI nanocomposite was greenly synthesized with Laminaria japonica extract and applied as a visible-light-driven photocatalyst for organic pollutant degradation.
Influence of cooling-induced edge morphology evolution during chemical vapor deposition on H2 etching of graphene domains
Authors: Wang Bin , Wang Yuwei , Wang Guiqiang , Zhang Qingguo
Published: February 2019

The entire morphological variation of CVD graphene during cooling and etching.
Efficient dehydrogenation of a formic acid–ammonium formate mixture over Au3Pd1 catalyst
Authors: Guo Xiao-Tong , Zhang Juan , Chi Jian-Chao , Li Zhi-Hui , Liu Yu-Chen , Liu Xin-Ru , Zhang Shu-Yong
Published: February 2019

The Au3Pd1/C catalyst shows better performance in a formic acid–ammonium formate mixture and the mechanism of dehydrogenation is discussed.
A novel apoptosis-inducing metabolite isolated from marine sponge symbiont Monascus sp. NMK7 attenuates cell proliferation, migration and ROS stress-mediated apoptosis in breast cancer cells
Authors: Nagabhishek Sirpu Natesh , Madankumar Arumugam
Published: February 2019

The marine environment has a remarkable source of natural products mainly from marine fungi, which have been a central source of novel pharmacologically bioactive secondary metabolites.
Boron nitride nanochannels encapsulating a water/heavy water layer for energy applications
Authors: Shayeganfar Farzaneh , Beheshtian Javad , Shahsavari Rouzbeh
Published: February 2019

Single layer water (SLW) on BN layer and encapsulated between bilayer BN (BLBN) as nanochannel.
Enzymatic synthesis of selenium-containing amphiphilic aliphatic polycarbonate as an oxidation-responsive drug delivery vehicle
Authors: Yang Xian-Ling , Xing Xiu , Li Jun , Liu Yan-Hong , Wang Na , Yu Xiao-Qi
Published: February 2019

A facile synthetic strategy based on enzymatic polymerization was developed to construct a ROS-responsive polycarbonate served as biocompatible drug vehicle.
Decontamination of organic pollutants from aqueous media using cotton fiber–graphene oxide composite, utilizing batch and filter adsorption techniques: a comparative study
Authors: Abd-Elhamid A. I. , Nayl A. A. , El. Shanshory Ahmed A. , Soliman Hesham M. A. , Aly H. F.
Published: February 2019

Cotton fiber–graphene oxide (C–GO) composite with high adsorptive properties towards the cationic dye, crystal violet (CV), was successfully fabricated by simple mixing of cotton fiber and GO in aqueous solution using a homogenizer.
A chemical reaction controlled by light-activated molecular switches based on hetero-cyclopentanediyls
Authors: Bresien Jonas , Kröger-Badge Thomas , Lochbrunner Stefan , Michalik Dirk , Müller Henrik , Schulz Axel , Zander Edgar
Published: February 2019

Biradicals were applied as molecular switches to control chemical reactions that involve the activation of small molecules. The mechanism was studied by experimental and computational methods.
A dinuclear ruthenium(ii) phototherapeutic that targets duplex and quadruplex DNA
Authors: Archer Stuart A. , Raza Ahtasham , Dröge Fabian , Robertson Craig , Auty Alexander J. , Chekulaev Dimitri , Weinstein Julia A. , Keane Theo , Meijer Anthony J. H. M. , Haycock John W. , MacNeil Sheila , Thomas James A.
Published: February 2019

A previously reported dinuclear DNA imaging probe has been converted into a phototherapeutic through the incorporation of RuII(TAP)2 fragments (TAP = 1,4,5,8-3 tetraazaphenanthrene).
Single-site metal–organic framework catalysts for the oxidative coupling of arenes via C–H/C–H activation
Authors: Van Velthoven Niels , Waitschat Steve , Chavan Sachin M. , Liu Pei , Smolders Simon , Vercammen Jannick , Bueken Bart , Bals Sara , Lillerud Karl Petter , Stock Norbert , De Vos Dirk E.
Published: February 2019

Heterogeneous palladium single-site MOF catalysts for the oxidative coupling of arenes via C–H/C–H: superior TONs due to active site isolation.
Confinement and crowding control the morphology and dynamics of a model bacterial chromosome
Authors: Swain Pinaki , Mulder Bela M. , Chaudhuri Debasish
Published: February 2019

Motivated by recent experiments probing the shape, size and dynamics of bacterial chromosomes in growing cells, we consider a circular polymer attached to side-loops to model the chromosome confined to a cylindrical cell, in the presence of cytoplasmic crowders.
Response of collagen matrices under pressure and hydraulic resistance in hydrogels
Authors: Maity Debonil , Li Yizeng , Chen Yun , Sun Sean X.
Published: February 2019

Extracellular matrices in animal tissue are hydrogels mostly made of collagen.
Controlling the stability of Pickering emulsions by pH-responsive nanoparticles
Authors: Qin Shiyi , Yong Xin
Published: February 2019

The interaction and stability of emulsion droplets can be actively manipulated by using polyelectrolyte-grafted nanoparticles as stabilizers.
Tuning the activity of N-doped carbon for CO2 reduction via in situ encapsulation of nickel nanoparticles into nano-hybrid carbon substrates
Authors: Yuan Cheng-Zong , Li Hong-Bao , Jiang Yi-Fan , Liang Kuang , Zhao Sheng-Jie , Fang Xiao-Xiang , Ma Liu-Bo , Zhao Tan , Lin Cong , Xu An-Wu
Published: February 2019

The activity of N–C for CO2 reduction was reasonably tuned by in situ encapsulation of nickel nanoparticles and explored by DFT calculations.
Self-supported VO2arrays decorated with N-doped carbon as an advanced cathode for lithium-ion storage
Authors: Chen Minghua , Liang Xinqi , Wang Fan , Xie Dong , Pan Guoxiang , Xia Xinhui
Published: February 2019

High-quality self-supported VO2arrays decorated with N-doped carbon (N–C@VO2) were fabricatedviaa facile solvothermal-polymerization approach for applications in lithium-ion batteries. The N–C@VO2arrays show high capacity (295 mA h g−1at 1C) and stable capacity: 95.3% retention after 500 cycles at 1C.
Photo-controlled bond changes on Pt/TiO2 for promoting overall water splitting and restraining hydrogen–oxygen recombination
Authors: Zhang Yajun , Hu Hongyan , Huang Xiaojuan , Bi Yingpu
Published: February 2019

Photo-induced chemical-bond reconstruction processes at Pt/TiO2 photocatalytic interfaces have been detected for the first time via synchronous illumination X-ray photoelectron spectroscopy combined with an angle-resolved technique.
Intelligent multiple-liquid evaporation power generation platform using distinctive Jaboticaba-like carbon nanosphere@TiO2 nanowires
Authors: Ji Bingxue , Chen Nan , Shao Changxiang , Liu Qianwen , Gao Jian , Xu Tong , Cheng Huhu , Qu Liangti
Published: February 2019

We prepared 0D/1D composite assembly by simulating the Jaboticaba tree and applied it in a light-control liquid evaporation power generation device.
An efficient PEDOT-coated textile for wearable thermoelectric generators and strain sensors
Authors: Jia Yanhua , Shen Lanlan , Liu Jing , Zhou Weiqiang , Du Yukou , Xu Jingkun , Liu Congcong , Zhang Ge , Zhang Zishan , Jiang Fengxing
Published: February 2019

Highly flexible PEDOT-based electronic textiles were successfully fabricated for wearable thermoelectric generators and strain sensors with high sensitivity and superior water durability.
High sensitivity detection of Escherichia coli based on the measurement of β-galactosidase activity by microchip capillary electrophoresis combined with field-amplified sample injection
Authors: Zhang Yan , Zhang Yating , Zhu Luqi , He Pingang , Wang Qingjiang
Published: February 2019

A sensitive strategy developed for the detection of Escherichia coli (E. coli) by microchip capillary electrophoresis (MCE) combined with laser-induced fluorescence (LIF) is described in this paper.
Ambient-temperature oxidative coupling of methane in an electric field by a cerium phosphate nanorod catalyst
Authors: Sato Ayaka , Ogo Shuhei , Kamata Keigo , Takeno Yuna , Yabe Tomohiro , Yamamoto Tomokazu , Matsumura Syo , Hara Michikazu , Sekine Yasushi
Published: February 2019

The application of an electric field to a CePO4 nanorod catalyst enabled ambient-temperature oxidative coupling of methane to C2 hydrocarbons.
Metal–organic frameworks with 5,5′-(1,4-xylylenediamino) diisophthalic acid and various nitrogen-containing ligands for selectively sensing Fe(iii)/Cr(vi) and nitroaromatic compounds
Authors: Xu Cungang , Bi Caifeng , Zhu Zheng , Luo Rong , Zhang Xia , Zhang Dongmei , Fan Chuanbin , Cui Liansheng , Fan Yuhua
Published: February 2019

Four Zn(ii) complexes are applied in selectively sensing Fe(iii)/Cr(vi) and nitroaromatic compounds.
α-Thiocarbonyl synthesisviathe FeII-catalyzed insertion reaction of α-diazocarbonyls into S–H bonds
Authors: Keipour Hoda , Jalba Angela , Tanbouza Nour , Carreras Virginie , Ollevier Thierry
Published: February 2019

Fe(OTf)2was used to catalyze the insertion reaction of α-diazocarbonyls into S–H bonds at 40 °C.
Controlling the microstructure of resorcinol–furfural aerogels and derived carbon aerogels via the salt templating approach
Authors: Zhang Haiming , Feng Junzong , Li Liangjun , Jiang Yonggang , Feng Jian
Published: February 2019

The control strategy for the microstructure of resorcinol–furfural (RF) aerogels and derived carbon aerogels is attracting attention in different applications such as adsorbents, electrochemical electrodes, thermal insulation and so on.
Sonochemistry-enabled uniform coupling of SnO2 nanocrystals with graphene sheets as anode materials for lithium-ion batteries
Authors: Han Xiaoyan , Li Ran , Qiu Shengqiang , Zhang Xiaofang , Zhang Qing , Yang Yingkui
Published: February 2019

SnO2/graphene nanocomposite was successfully synthesized by a facile sonochemical method from SnCl2 and graphene oxide (GO) precursors.
Digital methods and tools for chemical equipment and plants
Authors: Kockmann Norbert
Published: February 2019

The Internet of Things (IoT), Industry 4.0, and the digitalization of business processes offer new opportunities and business models for the process industry, including education and training.
Photocatalytic C–H silylation of heteroarenes by using trialkylhydrosilanes
Authors: Liu Shihui , Pan Peng , Fan Huaqiang , Li Hao , Wang Wei , Zhang Yongqiang
Published: February 2019

A distinctive visible light-promoted photocatalytic approach for the C–H silylation of heteroarenes by using trialkylhydrosilanes was developed.
Correction: Synthetic 2-D lead tin sulfide nanosheets with tuneable optoelectronic properties from a potentially scalable reaction pathway
Authors: Norton Kane , Kunstmann Jens , Ping Lu , Rakowski Alexander , Wang Chuchen , Marsden Alexander J. , Murtaza Ghulam , Zeng Niting , McAdams Simon G. , Bissett Mark A. , Haigh Sarah J. , Derby Brian , Seifert Gotthard , Ke Jack Chun-Ren , Lewis David J.
Published: February 2019

Correction for ‘Synthetic 2-D lead tin sulfide nanosheets with tuneable optoelectronic properties from a potentially scalable reaction pathway’ by Kane Norton et al., Chem. Sci., 2019, 10, 1035–1045.
A nitrogen-containing all-solid-state hyperbranched polymer electrolyte for superior performance lithium batteries
Authors: Zhang Lei , Wang Shi , Li Jingyu , Liu Xu , Chen Pingping , Zhao Tong , Zhang Liaoyun
Published: February 2019

A novel nitrogen-containing all-solid-state hyperbranched polymer electrolyte is first designed and prepared and shows superior performance.
Design of doped cesium lead halide perovskite as a photo-catalytic CO2 reduction catalyst
Authors: Tang Chao , Chen Chongyang , Xu Weiwei , Xu Lai
Published: February 2019

The stronger absorption of intermediate molecules, the lower free energy barrier, and the smaller band gap as well as the charge accommodation mechanism compared with the intrinsic case reveal that Co-doped CsPbBr3 could be a promising candidate for CO2 reduction.
Photo-triggerable liposomal drug delivery systems: from simple porphyrin insertion in the lipid bilayer towards supramolecular assemblies of lipid–porphyrin conjugates
Authors: Massiot Julien , Rosilio Véronique , Makky Ali
Published: February 2019

Light-responsive liposomes are considered nowadays as one of the most promising nanoparticulate systems for the delivery and release of an active pharmaceutical ingredient (API) in a spatio-temporal manner.
Hierarchical Bayesian model to inferPL(Z)relations usingGaiaparallaxes
Authors: Delgado H. E. , Sarro L. M. , Clementini G. , Muraveva T. , Garofalo A.
Published: February 2019

In a recent study we analysed period–luminosity–metallicity (PLZ) relations for RR Lyrae stars using theGaiaData Release 2 (DR2) parallaxes. It built on a previous work that was based on the firstGaiaData Release (DR1), and also included period–luminosity (PL) relations for Cepheids and RR Lyrae stars. The method used to infer the relations fromGaiaDR2 data and one of the methods used forGaiaDR1 data was based on a Bayesian model, the full description of which was deferred to a subsequent publication. This paper presents the Bayesian method for the inference of the parameters ofPL(Z) relations used in those studies, the main feature of which is to manage the uncertainties on observables in a rigorous and well-founded way. The method encodes the probability relationships between the variables of the problem in a hierarchical Bayesian model and infers the posterior probability distributions of thePL(Z) relationship coefficients using Markov chain Monte Carlo simulation techniques. We evaluate the method with several semi-synthetic data sets and apply it to a sample of 200 fundamental and first-overtone RR Lyrae stars for whichGaiaDR1 parallaxes and literatureKs-band mean magnitudes are available. We define and test several hyperprior probabilities to verify their adequacy and check the sensitivity of the solution with respect to the prior choice. The main conclusion of this work, based on the test with semi-syntheticGaiaDR1 parallaxes, is the absolute necessity of incorporating the existing correlations between the period, metallicity, and parallax measurements in the form of model priors in order to avoid systematically biased results, especially in the case of non-negligible uncertainties in the parallaxes. The relation coefficients obtained here have been superseded by those presented in our recent paper that incorporates the findings of this work and the more recentGaiaDR2 measurements.
Star formation and gas in the minor merger UGC 10214
Authors: Rosado-Belza D. , Lisenfeld U. , Hibbard J. , Knierman K. , Ott J. , Verley S. , Boquien M. , Jarrett T. , Xu C. K.
Published: February 2019

Minor mergers play a crucial role in galaxy evolution. UGC 10214 (the Tadpole galaxy) is a prime example of this process in which a dwarf galaxy has interacted with a large spiral galaxy ∼250 Myr ago and produced a perturbed disc and a giant tidal tail. We used a multi-wavelength dataset that partly consists of new observations (Hα, HI, and CO) and partly of archival data to study the present and past star formation rate (SFR) and its relation to the gas and stellar mass at a spatial resolution down to 4 kpc. UGC 10214 is a high-mass (stellar mass M⋆ = 1.28 × 1011 M⊙) galaxy with a low gas fraction (Mgas/M⋆ = 0.24), a high molecular gas fraction (MH2/MHI = 0.4), and a modest SFR (2–5 M⊙ yr−1). The global SFR compared to its stellar mass places UGC 10214 on the galaxy main sequence (MS). The comparison of the molecular gas mass and current SFR gives a molecular gas depletion time of about ∼2 Gyr (based on Hα), comparable to those of normal spiral galaxies. Both from a comparison of the Hα emission, tracing the current SFR, and far-ultraviolet (FUV) emission, tracing the recent SFR during the past tens of Myr, and also from spectral energy distribution fitting with CIGALE, we find that the SFR has increased by a factor of about 2–3 during the recent past. This increase is particularly noticeable in the centre of the galaxy where a pronounced peak of the Hα emission is visible. A pixel-to-pixel comparison of the SFR, molecular gas mass, and stellar mass shows that the central region has had a depressed FUV-traced SFR compared to the molecular gas and the stellar mass, whereas the Hα-traced SFR shows a normal level. The atomic and molecular gas distribution is asymmetric, but the position-velocity diagram along the major axis shows a pattern of regular rotation. We conclude that the minor merger has most likely caused variations in the SFR in the past that resulted in a moderate increase of the SFR, but it has not perturbed the gas significantly so that the molecular depletion time remains normal.
KiDS+GAMA: Intrinsic alignment model constraints for current and future weak lensing cosmology
Authors: Johnston Harry , Georgiou Christos , Joachimi Benjamin , Hoekstra Henk , Chisari Nora Elisa , Farrow Daniel , Fortuna Maria Cristina , Heymans Catherine , Joudaki Shahab , Kuijken Konrad , Wright Angus
Published: February 2019

We directly constrain the non-linear alignment (NLA) model of intrinsic galaxy alignments, analysing the most representative and complete flux-limited sample of spectroscopic galaxies available for cosmic shear surveys. We measure the projected galaxy position-intrinsic shear correlations and the projected galaxy clustering signal using high-resolution imaging from the Kilo Degree Survey (KiDS) overlapping with the GAMA spectroscopic survey, and data from the Sloan Digital Sky Survey. Separating samples by colour, we make no significant detection of blue galaxy alignments, constraining the blue galaxy NLA amplitude AIAB = 0.21−0.36+0.37 to be consistent with zero. We make robust detections (∼9σ) for red galaxies, with AIAR = 3.18−0.46+0.47, corresponding to a net radial alignment with the galaxy density field, and we find no evidence for any scaling of alignments with galaxy luminosity. We provide informative priors for current and future weak lensing surveys, an improvement over de facto wide priors that allow for unrealistic levels of intrinsic alignment contamination. For a colour-split cosmic shear analysis of the final KiDS survey area, we forecast that our priors will improve the constraining power on S8 and the dark energy equation of state w0, by up to 62% and 51%, respectively. Our results indicate, however, that the modelling of red/blue-split galaxy alignments may be insufficient to describe samples with variable central/satellite galaxy fractions.
Ancient and primordial collisional families as the main sources of X-type asteroids of the inner main belt
Authors: Delbo Marco , Avdellidou Chrysa , Morbidelli Alessandro
Published: February 2019

Aims. The near-Earth asteroid population suggests the existence of an inner main belt source of asteroids that belongs to the spectroscopic X complex and has moderate albedos. The identification of such a source has been lacking so far. We argue that the most probable source is one or more collisional asteroid families that have escaped discovery up to now.

Methods. We apply a novel method to search for asteroid families in the inner main-belt population of asteroids belonging to the X complex with moderate albedo. Instead of searching for asteroid clusters in orbital element space, which could be severely dispersed when older than some billions of years, our method looks for correlations between the orbital semimajor axis and the inverse size of asteroids. This correlation is the signature of members of collisional families that have drifted from a common centre under the effect of the Yarkovsky thermal effect.

Results. We identify two previously unknown families in the inner main belt among the moderate-albedo X-complex asteroids. One of them, whose lowest numbered asteroid is (161) Athor, is ~3 Gyr old, whereas the second one, whose lowest numbered object is (689) Zita, could be as old as the solar system. Members of this latter family have orbital eccentricities and inclinations that spread them over the entire inner main belt, which is an indication that this family could be primordial, that is, it formed before the giant planet orbital instability.

Conclusions. The vast majority of moderate-albedo X-complex asteroids of the inner main belt are genetically related, as they can be included into a few asteroid families. Only nine X-complex asteroids with moderate albedo of the inner main belt cannot be included in asteroid families. We suggest that these bodies formed by direct accretion of the solids in the protoplanetary disc, and are thus surviving planetesimals.