bluuebunny/crossref_metadata_2025 huggingface dataset:
Current possibilities of predicting the therapeutic response to neoadjuvant chemoradiotherapy in rectal cancer
Authors: Pazdírek Filip , Minárik Marek , Benešová Lucie , Hoch Jiří , Lohynská Radka
Published: November 2020

Neoadjuvant chemotherapy in combination with radiation is currently the standard of care for patients with locally advanced rectal cancer. The main purpose of the treatment is to reduce the risk of recurrence, however at the same time it may be accompanied by severe adverse effects due to post-radiation pelvic damage. An effort towards finding markers allowing the prediction of the therapy response has been undertaken by many groups. In this review we have performed a literature search to identify the main studies directed at the use of clinical, radiological, immunological and molecular (protein, DNA and RNA) markers. We present a summary for each group with an overall conclusion that a certain level of ambiguity and disunity in interpretation of the results currently exists among the reported findings. Apparently, even in the most promising direction of circulating molecular bio­markers further work is needed before a clinical utility can be established.
DUAL A TEOLOGIJA PŘINOŠK K PROBLEMATICE WUŽIWANJA DUALOWYCH FORMOW W HORNJOSERBSKICH PŘEŁOŽKACH BIBLIJE
Authors: DZIKIEWICZ DANIEL
Published: November 2020

This article describes the relations between dual grammatical number and theology. The original thesis was: Upper Sorbian translations of the Bible contain theologically problematic uses of dual forms. The hypothesis is accompanied by an analysis of the exegesis and theology of the periscopes Gen 1, 28; Mt 20, 23; £k 2, 7; J 1, 41 and 17, 21. Application or failure to apply dual forms in the texts in question poses significant problems on the level of theology. This article contains also a suggestion of certain rules to be followed in future revisions of the existing translation of the Upper Sorbian Bible. Firstly, the use of dual grammatical number should go hand in hand with the theological perspective of the biblical texts. Secondly, in cases when the category of dual grammatical number cannot accommodate theology, the latter should be a priority.
Gabriela Olchowa, System adresatywny języka polskiego i słowackiego na początku XXI wieku. Gaudeamus, Hradec Králové 2018, ss. 240
Authors: BALOWSKI MIECZYSŁAW
Published: November 2020

Gabriela Olchowa, System adresatywny języka polskiego i słowackiego na początku XXI wieku. Gaudeamus, Hradec Králové 2018, ss. 240
ROLA PRZYSŁÓWKÓW WSCHODNIOSŁOWIAŃSKICH W ŚWIADOMOŚCI UŻYTKOWNIKÓW GWAR POLSKICH W OBWODZIE LWOWSKIM W PRZEKROJU POKOLENIOWYM
Authors: KOSTECKA-SADOWA ANNA
Published: November 2020

This article presents and verifies material embedded in the awareness of users of Polish spoken in the southern part of Eastern Borderlands of the country across generations. The close relation between Polish and Ukrainian languages is conducive to the emergence of numerous interferences. Inclusion of Ukrainian features into the Polish system took place in the course of many centuries of contacts with speakers of the Ukrainian language. Ukrainian subdialects have left their mark on the Polish language in the southern part of Eastern Borderlands also in formations which deviate from the literary language. In the Polish language under scrutiny – the language spoken on the Polish-Ukrainian borderland, some formations follow Ukrainiansubdialects and the entire Eastern Slavic area. A majority of adverbs have a structure compliant with the general Polish language. However, there are also different formations, typical of borderland subdialects.
OGNIEM I MIECZEM – LEKCJA SZLACHECKIEGO SAVOIR-VIVRE’U
Authors: SIKORA KAZIMIERZ
Published: November 2020

Polish linguistic courtesy owes a lot to the gentry’s culture and courtly culture in general. As research suggests, centuries ago the major and specific norms of Polish etiquette (the special position of women) emerged while the noble and courtly origin of the majority of the contemporary forms of address is beyond doubt. Due to the dominant impact of the aristocratic and courtly model of courtesy on the linguistic habits of contemporary Poles and their ancestors, it seemed interesting and useful to present and describe selected elements of Sarmatism’s linguistic etiquette from today’s perspective (with special emphasis placed on words of greetings and farewells) included in Henryk Sienkiewicz’s famous historical novel, Ogniem i mieczem [With Fire and Sword]. This attempt was also stimulated by the book’s cognitive value and the author’s impressive knowledge of the Polish gentry in the mid-17th century, obtained as a result of studies of the literary diaries available to him. Therefore, the attempt made to recreate the world of gentry’s culture and its model of Old Polish etiquette is not just a product of the author’s imagination and it continues to inspire contemporary readers.
“Se eu fosse fazer transição, eu era jogada na rua”: vida precária, universo trans e educação
Authors: Silva Fernando Guimarães Oliveira da , Maio Eliane Rose
Published: November 2020

Enaltecer vidas diferentes leva-nos a produzir estratégias para reconhecê-las possíveis. Partir do reconhecimento precário de uma vida requer problematizar discussões que a enquadram em uma moldura sem inteligibilidade. Logo, sob o enfoque da pesquisa pós-crítica em educação, com a utilização da arqueologia foucaultiana, acessamos, neste artigo, narrativas de memórias discursivas da época de transição de gênero na escola, na família e na comunidade, de uma das participantes da pesquisa realizada durante o Curso de Doutorado em Educação, Luna. O método utilizado para a coleta de dados, com o objetivo de encontrar memórias de cartografia de vidas que se chocaram com as regras, desenharam contornos subversivos e, ainda assim, permaneceram em ambiente escolar, foi a entrevista narrativa. Por meio dessa ferramenta, foi possível acompanhar e analisar a construção subjetiva de gênero feminino de Luna, que, durante esse processo, previu projetos de vida possíveis nos quais a educação representou uma forma de resistência e ruptura com a precariedade da vida que atinge pessoas trans.
Formas e tendências de precarização do trabalho docente e os influxos do empresariamento na educação
Authors: Silva Amanda Moreira da , Gomes Thayse Ancila Maria de Melo , Motta Vânia Cardoso da
Published: November 2020

Este artigo discute o trabalho docente na educação básica pública brasileira, sob o viés da precarização e do empresariamento em curso, enfocando as formas de contratação temporária e eventual de professores, assim como as tendências de terceirização, pejotização e uberização, surgidas nos últimos anos. Apresenta análises de dados estatísticos de nível nacional e de documentos públicos e oficiais de Secretarias de Educação municipais e estaduais, bem como dialoga com outras pesquisas sobre a temática que permitiram situar tais contratações atípicas no bloco histórico neoliberal e no processo de empresariamento da educação. Evidencia que tal processo corrói a carreira docente, enfraquece a capacidade política coletiva dos professores e submete o docente a condições cada vez mais precárias de trabalho, promovendo sua desqualificação com vistas a sua requalificação dentro da lógica empresarial.
Cell Type-Specific Oxidative Stress Genomic Signatures in the Globus Pallidus of Dopamine-Depleted Mice
Authors: Lawler Alyssa J. , Brown Ashley R. , Bouchard Rachel S. , Toong Noelle , Kim Yeonju , Velraj Nitinram , Fox Grant , Kleyman Michael , Kang Byungsoo , Gittis Aryn H. , Pfenning Andreas R.
Published: November 2020

Neuron subtype dysfunction is a key contributor to neurologic disease circuits, but identifying associated gene regulatory pathways is complicated by the molecular complexity of the brain. For example, parvalbumin-expressing (PV+) neurons in the external globus pallidus (GPe) are critically involved in the motor deficits of dopamine-depleted mouse models of Parkinson's disease, where cell type-specific optogenetic stimulation of PV+neurons over other neuron populations rescues locomotion. Despite the distinct roles these cell types play in the neural circuit, the molecular correlates remain unknown because of the difficulty of isolating rare neuron subtypes. To address this issue, we developed a new viral affinity purification strategy, Cre-Specific Nuclear Anchored Independent Labeling, to isolate Cre recombinase-expressing (Cre+) nuclei from the adult mouse brain. Applying this technology, we performed targeted assessments of the cell type-specific transcriptomic and epigenetic effects of dopamine depletion on PV+and PV–cells within three brain regions of male and female mice: GPe, striatum, and cortex. We found GPe PV+neuron-specific gene expression changes that suggested increased hypoxia-inducible factor 2α signaling. Consistent with transcriptomic data, regions of open chromatin affected by dopamine depletion within GPe PV+neurons were enriched for hypoxia-inducible factor family binding motifs. The gene expression and epigenomic experiments performed on PV+neurons isolated by Cre-Specific Nuclear Anchored Independent Labeling identified a transcriptional regulatory network mediated by the neuroprotective factor Hif2a as underlying neural circuit differences in response to dopamine depletion.

SIGNIFICANCE STATEMENTCre-Specific Nuclear Anchored Independent Labeling is an enhanced, virus-based approach to isolate nuclei of a specific cell type for transcriptome and epigenome interrogation that decreases dependency on transgenic animals. Applying this technology to GPe parvalbumin-expressing neurons in a mouse model of Parkinson's disease, we discovered evidence for an upregulation of the oxygen homeostasis maintaining pathway involving Hypoxia-inducible factor 2α. These results provide new insight into how neuron subtypes outside the substantia nigra pars compacta may be compensating at a molecular level for differences in the motor production neural circuit during the progression of Parkinson's disease. Furthermore, they emphasize the utility of cell type-specific technologies, such as Cre-Specific Nuclear Anchored Independent Labeling, for isolated assessment of specific neuron subtypes in complex systems.
Mapping the Dynamic Recruitment of Spinal Neurons during Fictive Locomotion
Authors: Rancic Vladimir , Ballanyi Klaus , Gosgnach Simon
Published: November 2020

The basic rhythmic activity that underlies stepping is generated by a neural network, situated in the spinal cord, known as the locomotor central pattern generator (CPG). While a series of lesion experiments have demonstrated that the mammalian locomotor CPG is distributed throughout the ventral portion of the caudal spinal cord, the specific transverse distribution of this neural network is unclear. Here we evoke fictive locomotor activity of various frequencies in upright spinal cords prepared from male and female neonatal mice. This preparation enables us to use an imaging approach to identify locomotor-related cells across the transverse plane of the spinal cord. Results indicate that there is a clear shift in the recruitment of cells toward the ventromedial, and away from the ventrolateral, spinal cord as the frequency of fictive locomotion increases. Surprisingly, the analysis of multiple frequencies of fictive locomotion in the same spinal cord indicates that few neurons are involved in locomotor outputs across multiple speeds. Collectively, these experiments allow us to map the transverse distribution of the locomotor CPG and highlight the pattern of dynamic recruitment that occurs within this neural circuit as the frequency is altered. Our findings are consistent with data indicating that there is a speed-dependent recruitment of interneuronal populations during locomotion and suggest that the locomotor CPG is not a static network, but rather the specific cells recruited vary extensively based on demand.

SIGNIFICANCE STATEMENTIn this article, we use an imaging approach to identify all those cells that are rhythmically active at the same frequency as fictive locomotion recorded from the ventral roots of the isolated spinal cord. These experiments allow us to map the distribution of locomotor-related cells across the transverse plane of the spinal cord and identify the recruitment pattern of these cells as the frequency of locomotor outputs is altered. Our results indicate that there are drastic changes in the specific neurons activated at different frequencies and provide support for the concept that the locomotor central pattern generator is a modular network with speed-dependent recruitment of interneuronal components.
Tecnología digital en el aprendizaje de temas transversales.
Authors: Sevillano García María Luisa
Published: November 2020

Con frecuencia constatamos que la seguridad en la calle está amenazada por peatones pendientes del móvil, sin mirar, ni escuchar nada, ni a nadie. Trabajadores absortos, descuidan sus funciones por atender al móvil. Las familias se mantienen en silencio siguiendo los movimientos de pantallas o llamadas que entorpecen la vida familiar. Hay centros escolares que restringen o prohíben totalmente los teléfonos. ¿Qué hacer en la enseñanza para dar respuesta a situaciones como éstas?. Son situaciones relacionadas con una tecnología que en principio debe ser integrada en la formación básica. Demandas sociales, ordenamientos legales y resultados de investigaciones, nos señalan vías de actuación docente dentro del marco escolar y en la áreas transversales. Para aprovechar la potencia de una herramienta virtual y de unos contenidos, se tienen que conocer y crear las condiciones necesarias para su aplicación. Es aquí donde entra en juego, pero de forma científica, la didáctica. La competencia didáctica digital debe ser reconocida, no buscando la simple competencia digital. Se trata de tender a desarrollar la capacidad y disponibilidad para saber integrar curricularmente contenidos digitalizados de forma analítica y crítica-reflexiva.
Tareas de orientación y aprendizajes transversales
Authors: Fernández Batanero José Maria
Published: November 2020

Los aprendizajes transversales contribuyen a dar significatividad y funcionalidad desde la conexión de los conocimientos disciplinares con los temas y contextos sociales, culturales y éticos presentes en el entorno inmediato del alumnado. Por lo tanto, el saber, el hacer y el ser en torno al medio ambiente, la salud, la convivencia democrática, la afectividad y sexualidad, entre otros, son aprendizajes integrales que permiten el pleno desarrollo como personas individuales y sociales. Su puesta en práctica va a implicar, entre otros aspectos, la presencia de la orientación y la acción tutorial como un factor de calidad y como parte fundamental de la función docente. En el presente trabajo recogemos, por un lado, los principios básicos y objetivos de la orientación y la acción tutorial con respecto a los aprendizajes transversales, así como las competencias genéricas y específicas para orientadores y tutores. Por otro, se establecen pautas sobre el papel de la orientación en la elaboración de proyectos educativos transversales, terminando con algunas consideraciones a cerca de la Educación para la Salud, como contenido transversal actual y global.
Análisis y modelación estadística del proceso de añejamiento de rones en una ronera cubana
Authors: García Castellanos Beatriz , Pérez Ones Osney , Zumalacárregui de Cárdenas Lourdes , Blanco Carvajal Idania , López de la Maza Luis Eduardo
Published: November 2020

The rum aging process shows volume losses, called wastage. The operation variables: product, boardwalk, horizontal and vertical positions, date, volume, alcoholic degree, temperature, humidity and aging time, recorded in databases, contain valuable information to study the process. The qualitative variables were processed using Weka 3.8.0 software while the quantitative variables underwent a statistical analysis using Statgraphics Centurion XVII.2. The biggest reductions correspond to barrels located in areas which solar irradiation, favoring the evaporation of the product. The variable temperature and humidity present very high variation coefficients; these factors are uncontrolled so a regulation process is suggested. A regression model was obtained that predicts the losses based on the variables: numerical month volume and aging time with mean square error values (ECM) and R2 of 0.115 and 95.88 % respectively.
Social aspect of the interethnic interaction
Authors:   Taras Shevchenko National University of Kyiv 60, Volodymyrska Str., Kyiv, 01033, Ukraine, Chernova K. O.
Published: November 2020

The article reviews the social aspect of the interethnic interaction and considers the issues concerning the tolerance of different ethnic groups.
Influence of the global financial economic crisis on the labor market of Ukraine’s metallurgical complex
Authors:   Consortium Industrial group, Naumov D. Yu.
Published: November 2020

By analyzing a large array of statistical data and the results of own observations, the author evaluates the degree of the effect of the financial-economic crisis of the personnel potential of Ukraine’s mining-metallurgical complex, indicates the main tendencies inherent in the labor market of the branch under modern conditions, and proposes some measures aimed at overcoming the crisis phenomena.
Influence of the cost of subordination to laws on some aspects of the social protection of the population
Authors:   Ukrainian State Employment Service Training Institute 17, Novovokzalna Str., Kyiv, 03038, Ukraine, Kuznetsova T. K.
Published: November 2020

The law subordination cost includes the expenses on both the access to a law and the continuation of activities in the frame of the law. In Ukraine, the latter are unjustifiedly high and force gradually the economic entities to pass to the «shadow» medium. First of all, this concerns the expenses related to the payment of taxes. Since the drawbacks in the payment of taxes affect significantly the sphere of social protection, this can destabilize, in the course of time, the socio-political situation in Ukraine, where almost 90% of the population consider themselves poor.
Consequences of the financial economic crisis in the sphere of employment and measures to overcome them
Authors:   Kharkiv Regional Employment Center 1a, Battleship Potemkin Str., Kharkiv, 61068, Ukraine, Minenko V. L.
Published: November 2020

The author considers peculiarities of the influence of the financial-economic crisis on the state in the sphere of employment in one of the eastern regions of Ukraine, the Kharkiv region, and analyzes the experience of a realization of a number of measures to overcome the crisis-induced phenomena.
Avaliação do paladar de idosos e sua relação com estado nutricional e hábitos alimentares
Authors: Gomes Darlise Rodrigues dos Passos , Schirmer Claudine Lamanna , Nolte Ângela de Oliveira Antunez , Bós Ângelo José Gonçalves , Venzke Janaína Guimarães
Published: November 2020

Objetivos: avaliar a prevalência de disgeusia (distorção ou diminuição do paladar) e a associação com o estado nutricional e as práticas alimentares em um grupo de idosos, assim como identificar os gostos mais afetados e preservados.Métodos: estudo transversal com amostra recrutada no Centro de Lazer para idosos no município de Porto Alegre, RS. Avaliou-se o paladar, através de tiras gustativas (“tastestrips”), e o estado nutricional, através do Índice de Massa Corporal. As práticas alimentares foram investigadas através de questionário. Para análise estatística utilizou-se os testes qui-quadrado e ANOVA, com nível de significância de p <0,05.Resultados: foram avaliados 62 idosos (84% feminino, média de 70±7,6 anos), prevalência de disgeusia foi 19,4% (n=12), detectou-se 58% de sobrepeso (n=36), 40,5% de eutrofia (n=25) e 1,5% de baixo peso (n=1), não sendo encontrada associação entre alteração de paladar e estado nutricional (p=0,397). Cerca de 55% dos idosos apresentaram consumo elevado de sódio. Não houve diferença na média de pontos para o gosto ácido entre os idosos que temperam a salada com limão ou vinagre e os que não o fazem (p=0,054 e p=0,935, respectivamente). A média de pontos para o gosto salgado não diferiu entre os que preparam as refeições com temperos ricos em sódio e os que não os utilizam (p=0,055). O doce foi o gosto mais preservado, enquanto o ácido mostrou-se mais reduzido.Conclusões: apesar de evidências contrárias, não se identificou impacto das alterações de paladar sobre o estado nutricional e as práticas alimentares. Ainda assim, novos estudos que incluam essas variáveis se fazem necessários.
Editorial
Authors: Team Editorial
Published: November 2020

Editorial
An ‘Old Amharic’ Commentary on the Nicene Creed
Authors: Appleyard David L.
Published: November 2020

Translation of a pre-modern Amharic commentary on the Nicene Creed in English. The text of a Commentary on the Nicene Creed (ṣälotä haymanot) which forms the subject of this paper appears at the end of a copy of the Psalter and Wǝddase Maryam belonging to the Ethiopian church at Däbrä Gännät in Jerusalem [MS JE 48 E = MS Dabra Gannat 186]. The text was copied and circulated privately by the late Roger Cowley, who also records that material similar in outline but different in detail is contained in the andǝmta-commentary on the Anaphora of the Nicene Fathers.
Register of International Scholars in Ethiopian and Eritrean Studies Supplement 2
Authors: Tafla Bairu
Published: November 2020

Supplement to the already printed Registers of International Scholars in Ethiopian and Eritrean Studies. The present compilation contains information of mainly scholars who were not included in Aethiopica 3 and 5 (=Aet3 / Aet5) and some who since then changed their addresses and/or projects.
Stefan Weninger: Das Verbalsystem des Altäthiopischen – Eine Untersuchung seiner Verwendung und Funktion unter Berücksichtigung des Interferenzproblems
Authors: Kapeliuk Olga
Published: November 2020

Review
Gäbrä Iyyäsus Kifle, ታሪኽ ትውልዲ ልሳን ግእዝ Tariḵ tǝwlǝddi lǝssan Gǝʿǝz [History of the origin of the Gǝʿǝz language – in Tigrinya]
Authors: Kapeliuk Olga
Published: November 2020

Review
Recent Publications
Authors: Team Editorial
Published: November 2020

Bibliography
Aux confins le feu, au centre le Paradis. Qoma Fasilädäs, un monastère royal dans l’Ethiopie du 17ème siècle
Authors: Wion Anaïs
Published: November 2020

Dissertation Abstract
“The Horn of Africa between History, Law and Politics”, Rome, 13–14 December 2002
Authors: Guazzini Federica
Published: November 2020

Conference Report
O ensino da disciplina de Projeto Arquitetônico auxiliado pela realidade aumentada
Authors: Silva Jonathan , Lima Jefferson Queiroz , Jucá Sandro César Silveira , Mesquita Adriano , Monteiro Aldayr de Oliveira
Published: November 2020

Os recursos tecnológicos são cada dia mais adotados dentro da escola, substituindo as tradicionais lousas. Os projetores multimídias, como exemplo, trazem consigo uma facilidade de apresentação de elementos textuais e de vídeos, potencializando, assim, o campo de ensino e aprendizagem na instituição escolar. O objetivo deste artigo é abordar o uso da tecnologia conhecida como Realidade Aumentada (RA) para que a instrução da disciplina de projeto arquitetônico seja construída de forma mais eficiente. Tal proposta visa sanar uma dificuldade coletiva de visualização tridimensional de elementos arquitetônicos representados em projeto bidimensional. A metodologia utilizada está caracterizada como qualitativa, e também como exploratória e descritiva, por meio de um experimento com uma edificação tridimensional e seu projeto arquitetônico com alunos do Curso Técnico em Edificações ofertado pelo Instituto Federal de Educação, Ciência e Tecnologia do Ceará (IFCE) campus Morada Nova. Tal pesquisa foi aprovada pelo Comitê de Ética e Pesquisa do próprio IFCE, um órgão colegiado interdisciplinar e independente em sua atuação e decisões de sua competência. Os resultados obtidos através da utilização indicam que o uso da RA incrementa a aprendizagem nesta área, sendo necessário apenas o uso de um smartphone com configurações simples e com acesso à internet, para que seja viável a aplicabilidade da RA.
Dual and multiple trisomies: analysis of 38 cases from 13 thousand karyotyped embryos and fetuses
Authors:   The Inter-provincial center of medical genetics and prenatal diagnosis, Kryvyi Rig, Ukraine, Veropotvelyan N.P.
Published: November 2020

The study presents data of different authors, as well as its own data on the frequency of multiple trisomies among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of chromosomal abnormalities (CA) in I and II trimesters of gestation. The objective: determining the frequency of occurrence of double (DT) and multiple trisomies (MT) among the early reproductive losses in the I trimester of pregnancy and live fetuses in pregnant women at high risk of occurrence of HA in I and II trimesters of gestation; establishment of the most common combinations of diesel fuel and the timing of their deaths compared with single regular trisomy; comparative assessment materinskogo age with single, double and multiple trisomies. Patients and methods. During the period from 1997 to 2016, the first (primary) group of products in 1808 the concept of missed abortion (ST) of I trimester was formed from women who live in Dnepropetrovsk, Zaporozhye, Kirovograd, Cherkasy, Kherson, Mykolaiv regions. The average term of the ST was 8±3 weeks. The average age of women was 29±2 years. The second group (control) consisted of 1572 sample product concepts received during medical abortion in women (mostly residents of Krivoy Rog) in the period of 5-11 weeks of pregnancy, the average age was 32 years. The third group was made prenatally karyotyped fruits (n = 9689) pregnant women with high risk of HA of the above regions of Ukraine, directed the Centre to invasive prenatal diagnosis for individual indications: maternal age, changes in the fetus by ultrasound (characteristic malformations and echo markers HA) and high risk of HA on the results of the combined prenatal screening I and II trimesters. From 11 th to 14 th week of pregnancy, chorionic villus sampling was performed (n=1329), with the 16th week – platsentotsentez (n=2240), 18 th and 24 th week – amniocentesis (n=6120). Results. A comparative evaluation of maternal age and the prevalence anembriony among multiple trisomies. Analyzed 13,069 karyotyped embryonic and fetal I-II trimester of which have found 40 cases of multiple trisomies – 31 cases in the group in 1808 missed abortion (2.84% of total HA), 3 cases including 1 572 induced medabortov and 7 cases during 9689 prenatal research (0.51% of HA). Determined to share the double trisomies preembrionalny, fetal, early, middle and late periods of fetal development. Conclusion. There were no significant differences either in terms of destruction of single and multiple trisomies or in maternal age or in fractions anembrionalnyh pregnancies in these groups. Key words: multiple trisomies, double trisomy, missed abortion, prenatal diagnosis.
Perinatal loss – psychological aspects of the obstetricians and gynecologists work (clinical lecture)
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Zhuk S.I. , Shchurevska O.D. ,   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Shlyahtina A.A. ,   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine
Published: November 2020

The article presents current approaches to case management of perinatal loss in the terms of psychology. The features and patterns of experiences of women, depending on the type of loss. The general guidelines regarding the construction of the physician-patient dialogue and algorithm of actions by the example of antenatal fetal death are described. Key words: perinatal loss, pregnancy, childbirth, the fetus, fetal death, psychological support.
The practical significance of lactate levels in fetal blood at his urgent condition
Authors:   Shupyk National Medical Academy of Postgraduate Education, Kуiv, Ukraine, Pehnyo N.V.
Published: November 2020

The objective: to establish whether the level of lactate in the blood of the fetus to be reliable criterion of his suffering and indication for changing tactics of childbirth. Patients and methods. The study included 511 pregnant women. Criteria for inclusion in the study: full-term births with singleton pregnancy, cephalic presentation fetus, the absence of membranes, opening the cervix 3 cm or more, according KTG questionable fetus. Included in the study are pregnant randomized into 2 groups. In the study group included 253 women in childbirth, in which the fetus at CTG rated as doubtful and determine the level of lactate in the blood taken from the skin presenting fetal head. The level of lactate measured succinct method using commercial strip test (Lactate Pro, Arkray, Kyoto, Japan). Tactics delivery determined according to the lactate levels: at <4.2 mmol / l – of delivery according to obstetric situation; 4.2-4.8 mmol / l – research again after 20 minutes; If normal level of lactate – of delivery according to obstetric situation; in the absence of normalization or improvement – prompt delivery; by level of> 4.8 mmol/l-emergency operative delivery. In the comparison group included 258 rodil with questionable condition of the fetus, which determine the level of lactate was not performed. Tactics birth in this group of patients was determined in accordance with the guidelines and regulations of Ministry of Health of Ukraine. Results. Proven method of determining the level of fetal blood lactate is technically simple to quickly get results, well tolerated, no significant complications. The level of fetal blood lactate is a sensitive marker of fetal urgent and therefore is a useful criterion for changing tactics of childbirth. As a result of proven algorithm was able to improve the newborn while reducing the frequency of operative delivery, which was 18.2% in rodil main group and 33.72% in the comparison group (p <0.01). Conclusion. 1. Determination of lactate in the blood taken from the skin of the fetal head presenting succinct method using commercial strip test (Lactate Pro, Arkray, Kyoto, Japan), to quickly obtain data on the availability of fetal acidosis. 2. The level of lactate in the blood of the fetus can serve as a diagnostic criterion of his suffering and indication for changing tactics of labor in this regard. 3. Simplicity and speed of this technique allows to recommend it for use in obstetric practice. Key words: urgent fetus, fetal blood lactate, tactics delivery.
The cytologic conclusion in accordance a terminology system The Bethesda system 2014: what's new?
Authors:   Medical laboratory Synevo, Kуiv, Ukraine, Rykovа O.V. , Bogomaz T.P. ,   Medical laboratory Synevo, Kуiv, Ukraine
Published: November 2020

The paper presents the principles of the conclusions Pap test in accordance with the terminology system Bethesda, 2014, and their correlation with other classifications cytological findings. Key words: cervical cancer, cervical screening, traditional cytology, liquid-based cytology, PAP-test, The Bethesda system.
Thromboembolic complications prevention in the obstetric practice
Authors:   Kharkiv Medical Academy of Postgraduate Education, Ukraine, Grishchenko O.V. , Bobrytska V.V. ,   Kharkiv Medical Academy of Postgraduate Education, Ukraine
Published: November 2020

The objective: To evaluate the clinical efficacy and safety of Enoxaparin-Pharmex for the prevention of thrombotic complications (pulmonary embolism) in the postoperative period in patients with moderate risk of these complications. Patients and methods. The study included 50 women after a caesarean section had an average degree of risk of pulmonary embolism. Patients were divided into the main group (n=25) and control group (n=25) in accordance with the treatment: patients of the main group received postoperative Еnoxaparin- Pharmex, group comparisons enoxaparin sodium (brand foreign manufacturer’s). Patients in both groups received the drug at a dose of 20 mg for 5 days, 1 time per day subcutaneously. Results. The research data analysis showed identity results of hemostasiogram of patients in the main group and the comparison group, no side effects after treatment in both groups. Conclusion. The clinical studies suggest the drug Enoxaparin-Pharmex is effective, safe LMWH, which can be used to prevent troboembolic complications, including post-operative treatment in obstetric practice. Spectrum of Enoxaparin-Pharmex can be extended to the prevention and treatment of thromboembolic conditions of varying severity with appropriate doses of the drug. Key words: Enoxaparin-Pharmex, prevention of pulmonary embolism.
Management of patients in conditions of female consultation at persistent course of papillomavirus infection of the cervix
Authors:   Kharkiv National Medical University, Ukraine, Shcherbina N.A. , Demidenko D.I. ,   Kharkiv National Medical University, Ukraine, Demidenko A.D. ,   Kharkiv National Medical University, Ukraine, Kapustnik N.V. ,   Kharkiv National Medical University, Ukraine
Published: November 2020

Under our supervision there were 66 women with a diagnosis of "dysplasia of cervical epithelium mild" on the background of persistent human papillomavirus infection (PVI). With the aim of improving the treatment of dysplasia of the 1st degree in rehabilitation activities after cryoablation there were applied drugs Distreptaza and inducer of interferon. The results of treatment were evaluated after 3 months. For patients of the 1st group (18 women) who underwent only cryoablation, the efficacy of therapy was 77.8%. In the 2nd group (22 women) after cryoablation was used inducer of interferon, the effectiveness made up of 90.9%. The maximum effect of treatment - 100% recorded in 3rd group (26 patients), where after cryoablation was carried out treatment with Distreptaza and inducer of interferon. The results of treatment obtained in this group allow to recommend the complex therapy of PVI in conditions of female consultation. Key words: dysplasia, HPV, cryosurgery, Distreptaza, inducer of interferon.
Pregnancy and labors at women with a hysteromyoma after reconstructive operations
Authors:   Odessa National Medical University, Ukraine, Zhovtenko O.V.
Published: November 2020

The objective: depression of frequency of obstetric and perinatal pathology at women who transferred before pregnancy a conservative myomectomy із on the basis of studying the clinical-ekhografical, hemodynamic, endocrinologic, metabolic and morphological features a condition of fetoplacental complex, and also improvement of algorithm of diagnostic and treatment-and-prophylactic actions. Patients and methods. Features of a clinical course of pregnancy and labors at 266 women with a hysteromyoma (in the anamnesis there was no expeditious treatment), which were divided into two groups depending on the sizes of myomatous knots are studied. Features of a clinical course of pregnancy and labors at 126 women who transferred a conservative myomectomy before pregnancy are studied. Pregnant women were divided into two groups from a technique of the performed operation and tactics of conducting pregnancy. Results. Results of the conducted researches testify to high risk of development of perinatal pathology at women with a hysteromyoma who were operated before pregnancy in volume of a conservative myomectomy. Conclusion. Use of the algorithm of diagnostic and treatment-and-prophylactic actions added with us allows to improve perinatal outcomes of a delivery of women of group of high risk. Key words: hysteromyoma, reconstructive operations, pregnancy, labors.
Features of the morphofunctional state of placenta in women with cesarean section in the anamnesis
Authors:   Kharkiv Medical Academy of Postgraduate Education, Ukraine, Nazarenko L.G. , Nedorezova K.M. ,   Kharkiv City Clinical Maternity Hospital No.6, Ukraine, Sorokina I.V. ,   Kharkiv National Medical University, Ukraine
Published: November 2020

The article presents the results of clinico-morphological and functional studies of the placenta status in women with caesarean section (CS) in anamnesis undertaken to determine the possible relationship of morphogenesis of the placenta with features of functional capability of the operated uterus. The aim of the study was to determine peculiarities of morpho-functional condition of placenta in women with a CS in anamnesis, with different variants of functional capability of the scar. Material and methods. Examined 30 women with a CS in anamnesis, including 15 with scheduled repeat CS, and 15 with attempted vaginal delivery. Special research methods: morphometric, histological and immunohistochemical. The research object - the placenta. Results. It is established that morpho-functional state of the placenta in the presence of the operated uterus is characterized by the inclusion of adaptive processes aimed at improving fetal-placental blood circulation. In case of operated uterus, “compromised” the lower segment, in the presence of a proper or pathological changed scar ? in the placenta do not exist involutive-dystrophic and sclerotic processes, takes place the activation of collagen formation, which is a compensatory mechanism. In the presence of insolvent the lower segment of the uterus in the placenta takes place the morphological equivalent of the intensity of compensatory reactions, which has the value of the factor aggravating perinatal prognosis, in turn, limits the chances of success of attempts at vaginal delivery. Conclusions. Morphogenesis of the placenta on the background of operated uterus characterized by the development of adaptive responses, the list of which depends on a morpho-functional characteristics of the lower segment, while the degree of manifestation of adaptive-compensatory mechanisms is determined by the fact of able or unable scar. Key words: cesarean section, placenta, vaginal labor.
Disorders of the autonomic nervous system in patients with leiomyoma associated with metabolic syndrome
Authors:   Bogomolets National Medical University, Kiev, Ukraine, Pavlovska M.
Published: November 2020

The objective: to examine the manifestations of autonomic nervous system dysfunction in women with uterine leiomyoma against the background of metabolic syndrome. Patients and methods. The study included 64 women (30 patients with uterine leiomyoma associated with metabolic syndrome, a group 1, and 34 healthy women, the control group). To characterize the state of the autonomic nervous system applied of A.M. Wayne was determined, index Kerdo, evaluated the degree of sleep according to the questionnaire of A.M. Wayne. Results. Kerdo index inclined in a positive direction and rate was 20.04. Established light sleep disturbances on tables A.M. Wayne in 36.7% of patients in normal – 2.94%, that indicate the presence of somaticaly-vegetative signs and an indication of dysfunctional deviations of the autonomic nervous system tone. Сonclusion. On the basis of subjective and objective signs of dominance tone of the sympathetic and parasympathetic nervous system in patients with uterine leiomyoma, associated with metabolic syndrome, found vahotonic option dysfunction of the autonomic nervous system. Kerdo index showed a negative sign, which is -3.6; in healthy individuals Key words: autonomic tone, uterine leiomyoma, the metabolic syndrome.
Exact Mode Shapes of T-shaped and Overhang-shaped Microcantilevers
Authors: Dat Le Tri , Lan Vu , Vy Nguyen Duy
Published: November 2020

Resonance frequencies and mode shapes of microcantilevers are of important interest in micro-mechanical systems for enhancing the functionality and applicable range of the cantilevers in vibration transducing, energy harvesting, and highly sensitive measurement. In this study, using the Euler-Bernoulli theory for beam, we figured out the exact mode shapes of cantilevers of varying widths such as the overhang- or T-shaped cantilevers. The obtained mode shapes have been shown to significantly deviate from the approximate forms of a rectangular cantilever that are commonly used in mechanics and physics. They were then used to figure out the resonance frequencies of the cantilever. The analytical solutions have been confirmed by using the finite element method simulations with very low deviation. This study suggested a method for correctly obtaining the resonance frequency of microcantilevers with complicated dimensions, such as the doubly clamped cantilever with the undercut, with the overhangs at the clamped positions, or with an attached mass in the middle.
Fear of childbirth in time of the new coronavirus pandemic
Authors: Souto Sandra Patrícia Arantes do , Albuquerque Rosemeire Sartori de , Prata Ana Paula
Published: November 2020

ABSTRACT Objective: Reflect on how the new coronavirus pandemic triggered or accentuated the fear of childbirth in pregnant women and affected childbirth care practices. Methods: Reflective analysis of women's pregnancy and childbirth experiences during the current pandemic, supported by the latest scientific evidence and recommendations on the topic. Results: Pregnancy and childbirth are life-changing events for women, but during the new coronavirus pandemic, fear and uncertainty have taken on an unprecedented dimension in the negative way that many pregnant women have anticipated and experienced childbirth. Final considerations: The current period has accentuated a chronic problem: a paternalistic system of health institutions in the approach to childbirth, dense with additional levels of fear in pregnant women. In this context, addressing the fear of childbirth means not giving up the promotion of safe and positive birth experiences for women.
Eventos Extremos de Precipitação no Litoral do Paraná (Baía de Paranaguá)
Authors: Amorim Ana Cleide Bezerra , Scudelari Ada Cristina , Cunha Cynara , Gonçalves José Eduardo
Published: November 2020

Resumo A ocorrência de eventos extremos de precipitação (EEP) no litoral do Paraná eleva o potencial de erosividade dos rios da região, além de causar inundações. Neste contexto, o objetivo deste estudo é analisar a tendência da intensidade e frequência dos EEP diários, além de analisar o ciclo horário dos extremos para a região costeira do Paraná e o ambiente sinótico. Coletaram-se os dados de precipitação e divergência do fluxo de umidade. Consideraram-se EEP diários acima do percentil 95 (EEP95). A análise de tendência linear através do teste Mann-Kendall, análise do ciclo diário e a distribuição espacial do ambiente sinótico foram estudados. Os resultados mostram que os EEP95 não apresentaram tendência significativa. Apesar do estudo limitar-se a uma única localidade, áreas de máxima convergência de umidade destacam o padrão da Zona de Convergência de umidade. Os resultados mostram que o limiar para um EEP95 diário é de 46,40 mm.dia−1; apenas durante a madrugada e na estação chuvosa, o ciclo diário dos EEP95 apresentou taxas horárias que atingiram o percentil 95. O período de janeiro a março, concentrou cerca de 50% EEP95, com a frequência de EEP95 diminuindo em anos de La Niña e aumentando em anos de El Niño e neutros.
45 anos de Pós-Graduação em Educação na Universidade Federal do Paraná: situação e desafios
Authors: Cury Carlos Roberto Jamil
Published: November 2020

RESUMO Este artigo, inspirado no texto proferido na comemoração de uma efeméride do Programa de Pós-Graduação em Educação da Universidade Federal do Paraná, tem como objetivo assinalar o sentido e o significado da Pós-Graduação no Brasil. A trajetória do Programa resume em si as dimensões do processo de desenvolvimento da Pós-Graduação em Educação. Concomitantemente ao seu crescimento quantitativo, para o qual a ação consciente do Estado Brasileiro foi fundamental por meio dos Planos Nacionais de Pós-Graduação, houve a irradiação da pesquisa sobre os problemas educacionais do ponto de vista da qualidade. Aos poucos, a Pós-Graduação foi se constituindo como um intelectual coletivo e autônomo da área. Como expressão disso, destaquem-se a presença do Programa nas reuniões anuais da área, as publicações e o empenho na formação de inúmeros mestres/mestras e doutores/doutoras. Ao mesmo tempo, o programa, junto com os outros programas de pós-graduação em Educação, participando da organização da educação nacional, não deixa de estar sujeito aos processos de avaliação conduzidos pela CAPES/MEC. O artigo assinala os riscos de retrocesso no conjunto da pós-graduação por políticas de governo que venham a ser desconstrutoras de avanços colhidos no financiamento e nos processos de participação dos pares na qualificação da área.
MORAL DELIBERATION BY NURSES AND MEMBERS OF THE ASSISTENTIAL ETHICS COMMITTEE IN A CLINIC OF MAGALLANES, CHILE
Authors: Barrientos Mireya Inés Triviños , Schneider Dulcinéia Ghizoni , Bustos Elide Mariela Alarcón
Published: November 2020

ABSTRACT Objective: to know how the nurses working in the Critical Care Unit for adults and the members of the Assistential Ethics Committee deliberate on the assistential ethical issues in a Clinic of Magallanes, Chile. Method: a qualitative research of an exploratory and descriptive character conducted in a Clinic of Magallanes, Chile. Data collection was performed by means of a semi-structured interview in the period from March to May 2018, with ten nurses working in the Critical Care Unit for adults and with four members of the Assistential Ethics Committee who were clinical professionals in different disciplines. The statements obtained were organized in Atlas.ti and analyzed in the light of the theoretical reference framework of ethics, of principalist bioethics, and of Diego Gracia's moral deliberative method. Results: the two professional teams that participated in the research showed having ethical values and principles: protection of human dignity; respect for the patients' rights in all scopes, contexts, and interventions, targeted to provide humanized clinical practices based on scientific evidence and in safeguarding the protection and fulfillment of the patients' rights. Conclusion: nurses show knowledge, empathy, and moral sensitivity when conducting the moral deliberative model in assistential problems. The members of the Assistential Ethics Committee deliberate as a team and come to an agreed upon conclusion, always thinking in the best respect and benefit for the patient's well-being, with empathy and prudence in decision-making as references.
Public policies and the insertion of old people in the labor market in Brazil
Authors: Sato Andrea Toshye , Lancman Selma
Published: November 2020

Abstract Objective: Discuss how Brazilian public policies aimed at old people address the right of the old people to decent work, and the promotion of their insertion and maintenance at work. Method: Bibliographic research was carried out to analyze the Brazilian public policies aimed at old people. In order to deepen the analysis of these policies, they were consulted in full on Brazilian government websites. The data was analyzed based on content analysis. Results: Among the public policies aimed at the old people those having some type of work-related disposition provision are: the National Policy for Old People, State Policy for Old People, Statute of the Elderly, and National Health Policy for Old People. The work-related propositions were categorized into: I. Creation of working conditions for old people; II. Preventing discrimination and encouraging the hiring of old people; III. Continuing education for old people; IV. Retirement; V. Work as a choice. Conclusion: Over time, Brazilian public policies aimed at old people have been improving the approach to decent work, and the promotion of the insertion and maintenance of old people in their work. However, there is still a lack of better advances and clarifications about the guidelines and recommendations related to work for old people, emphasizing the importance of work contexts considering the conditions and organizations impacting the possibility of insertion and maintenance of old people at work.