bluuebunny/crossref_metadata_2025 huggingface dataset:
Industrial technologies for processing waste oils
Authors:   ООО «Rosa-1», Stan'kovski L. , Dorogochinskaya V.A. ,   National University of Oil and Gas «Gubkin University», Tonkonogov B.P. ,   National University of Oil and Gas «Gubkin University», Molokanov A.A. ,   National University of Oil and Gas «Gubkin University»
Published: March 2021

A brief review of the state of collection, disposal and processing of used oils shows the availability of their resource in the country and the main trends in the organization of qualified collection, disposal and processing according to the lubricating oil version. The relevant technologies are given for individual stages and in general for enterprises, the choice of which depends on the quality and characteristics of raw materials. The advantage of the technological scheme, including coagulation purification at the stage of raw material preparation and vacuum distillation with the selection of distillate fractions and the residue, followed by additional purification of the residue, is shown. The use of this technology makes it possible to increase the yield and quality of the target product, which is practically impossible for the raw materials currently available in the Russian Federation using other technologies.
The Celebrity Family Endorsement on Instagram Product Advertisement (Case: The Hermansyah)
Authors: Pramudya Sakti Hendra
Published: March 2021

The main purpose of this study is to analyze the consumer’s perception of single celebrity endorsement and celebrity family endorsement in the context of Instagram advertising. Instagram is selected as the research context due to the application has become a new trend in Asia and there are abundant people who use it as a media for promotion. The object of this research is Anang and Ashanty family business. They are a famous celebrity couple in Indonesia which successfully established numerous product lines, as well as a variety of brands and, interestingly, both Anang and Ashanty (along with their children), are the advertisement models of all of their product in the Instagram. The paper comprises of two separate studies. The first study would use 2 x 2 factorial design to compare the Instagram user’s response towards four stimuli of Instagram advertisements. Two stimuli would depict Instagram advertisement of single celebrity endorser (represents by Ashanty) and the other two stimuli would depict Instagram advertisement of celebrity family endorser (represents by Anang and Ashanty family). The stimulus is taken from the original advertisement from the couple’s product lines which represents by one cake product and one acne cream product. The second study is a consumer’s opinion survey which measures respondent’s opinion towards the advertisements. Based on the survey results of 547 Instagram users in Indonesia, it is revealed that celebrity family advertisement emerged higher than single celebrity advertisement for the acne cream product. Hence, it can be concluded that the consumer does value celebrity family endorsement more than individual or single celebrity endorsement. However, further analysis reveals that the engagement only exists in the initial stage (attention) and the middle stage (desire and search) of consumer’s psychological process to purchase a new product due to all of the advertisement is lacking information about the price.

Keywords: Family Business Branding, Single Celebrity Endorsement, Celebrity Family Endorsement, Instagram.
The Effects of Different Modes of Delivery on the Structure and Predicted Function of Intestinal Microbiota in Neonates and Early Infants
Authors: PAN KAIYU , ZHANG CHENGYUE , TIAN JUN
Published: March 2021

Several studies have shown that an increased risk of metabolic and immune disorders associated with cesarean section mode of delivery may exist. However, such studies have not been conducted in the Chinese population. Stool sample sequencing of the gene encoding the 16S rRNA of 82 prospectively enrolled 3- and 30–42-day-old vaginal and cesarean section delivered newborns was performed to study the composition and predicted function of the intestinal microbiota. In the samples from the 3-day-old neonates, the levels of Escherichia-Shigella in the two groups were similar. The genera Bifidobacterium, Lactobacillus, and Bacteroides were more prominent in the vaginal delivery than in the cesarean section group, which showed a predominance of Staphylococcus, Streptococcus, and Corynebacterium. The differences between the two groups were statistically significant (p < 0.05). In the samples from 30- to 42-day-old infants, Bifidobacterium, Lactobacillus, Escherichia-Shigella, and Bacteroides were the main genera present in the vaginal delivery group, while in the cesarean section delivery group; the predominant genera were Escherichia-Shigella, Bifidobacterium, Bacteroides, and Staphylococcus. Predicted functions of the vaginal delivery group revealed higher metabolic and biodegradation rates of carbohydrates, vitamins, and xenobiotics than those in the cesarean section group, which contributed to the stability of the microbiota in the former. The abundance of probiotic bacteria such as Bifidobacterium and Lactobacillus, and the negative correlation between obesity and Bacteroides presence were higher in vaginally delivered infants than in cesarean-delivered infants at both studied time points.
The Pathogenesis of Aspergillus fumigatus, Host Defense Mechanisms, and the Development of AFMP4 Antigen as a Vaccine
Authors: GU XIANG , HUA YAN-HONG , ZHANG YANG-DONG , BAO DI , LV JIN , HU HONG-FANG
Published: March 2021

Aspergillus fumigatus is one of the ubiquitous fungi with airborne conidia, which accounts for most aspergillosis cases. In immunocompetent hosts, the inhaled conidia are rapidly eliminated. However, immunocompromised or immunodeficient hosts are particularly vulnerable to most Aspergillus infections and invasive aspergillosis (IA), with mortality from 50% to 95%. Despite the improvement of antifungal drugs over the last few decades, the therapeutic effect for IA patients is still limited and does not provide significant survival benefits. The drawbacks of antifungal drugs such as side effects, antifungal drug resistance, and the high cost of antifungal drugs highlight the importance of finding novel therapeutic and preventive approaches to fight against IA. In this article, we systemically addressed the pathogenic mechanisms, defense mechanisms against A. fumigatus, the immune response, molecular aspects of host evasion, and vaccines’ current development against aspergillosis, particularly those based on AFMP4 protein, which might be a promising antigen for the development of anti-A. fumigatus vaccines.
Методичні положення оцінювання можливостей стримування агресора від розв’язання воєнного конфлікту
Authors: Загорка О. М. , Поліщук С. В. , Загорка І. О.
Published: March 2021

Стримування агресора від розв’язання воєнного конфлікту є одним з основних завдань забезпечення воєнної безпеки держави. У статті наведені методичні положення оцінювання можливостей стримування агресії, які базуються на урахуванні коефіцієнтів експансії конфлікту. Під час оцінювання можливостей стримування агресії розглядаються очікувані стратегії дій сторін, які характеризуються ймовірностями завершення воєнного конфлікту в кожній фазі (на кожному) етапі воєнних дій.

Наведені методичні положення утворюють концептуальну аналітичну модель стримування агресора, призначену не лише для оцінювання можливостей стримування агресії, а й для обґрунтування заходів з метою запобігання ескалації воєнного конфлікту. Порядок застосування моделі показаний на прикладі оцінювання можливостей стримування агресора від розв’язання воєнного конфлікту з метою відокремлення окремих районів держави.
Методика обґрунтування потрібного складу угруповання тактичної авіації повітряних сил в операціях
Authors: Горбенко В. М. , Коршець О. А.
Published: March 2021

У статті на основі порівняння визначеного значення потрібного льотного ресурсу тактичної авіації в операції (бойових діях) з математичним сподіванням числа літако-вильотів за визначений період запропоновано методику обґрунтування потрібного складу угруповання тактичної авіації Повітряних Сил для виконання завдань в операціях (бойових діях), яка також може бути застосована для оцінювання спроможностей і визначення можливостей створеного угруповання авіації визначеного складу.
Creación y fortalecimiento de las MiPymes en el sector confecciones del Área Metropolitana Centro Occidente
Authors: Barco Ortega Jhoao Paolo
Published: March 2021

Pereira durante varios años ha estado entre los 10° primeros lugar entre las ciudades más competitivas a nivel nacional, facilitado por las estrategias de competitividad y su responsabilidad social empresarial, sin embargo, no ha presentado un ascenso debido a la falta de inclusión de otros factores, por lo tanto, con este proyecto se buscó observar e identificar cuáles eran los componentes faltantes requeridos para mejorar la eficiencia de estas.Para lograr evidenciar, recopilar y crear nuevas estrategias y modelos que posibiliten la creación y fortalecimiento de MiPymes en el sector confecciones en el área metropolitana centro occidente, en busca de una mayor rentabilidad económica se indago cuáles eran las diferentes acciones que fomentaban los alcaldes locales como ayuda a las MiPymes en las que el sector confecciones puede sacar un mayor provecho si son puesta en marcha.
Semejanzas y diferencias de las medidas de protección de los menores hijos de mujeres privadas de la libertad - Colombia y México
Authors: Garzón Amaya Ana María , Henao Zapata David , Calderón Cárdenas Astrid Milena
Published: March 2021

En el presente trabajo se exponen las medidas de protección de menores que conviven con sus madres en centros penitenciarios, aplicadas en los ordenamientos jurídicos de Colombia y México, cómo se encuentra definido en sus Constituciones y demás normatividad, además se plantean las opiniones de doctrinantes expertos en la materia, por medio de una indagación bibliográfica para dar a conocer el alcance de las medidas de protección desde los puntos anteriores, dejando como resultado que los países objeto de comparación de acuerdo a semejanzas y diferencias propenden por adaptar las medidas establecidas, que son de aplicación especial y de mucha importancia ya que se habla de menores de edad, y de sus madres, qué son sujetos de especial protección, a quienes no se les puede negar sus derechos humanos y menos los fundamentales cuando se encuentran a cargo de alguna entidad estatal, como los centros penitenciarios.
Oposición política derecho comparado entre el país de Colombia, Ecuador y Perú
Authors: Ospina Llanos Melany , Serna Alzate Margarita María
Published: March 2021

La presente investigación tiene como objeto de estudio el tema concerniente a la oposición política desde el derecho comparado entre los países de Colombia, Ecuador y Perú. Con el fin de obtener un escenario jurídico frente al amparo legal, constitucional, doctrinal y jurisprudencial sobre la participación democrática de los partidos contrarios a la administración política que ostenta el poder en cada Estado, así como las garantías particulares para hacer uso de este derecho intrínseco del ser humano, dado el aspecto individual y/o grupal del “pensar diferente” o del tener un razonamiento contrario a un grupo del poder de manera crítica y cuestionable, para así, objetivamente establecer una conclusión comparativa entre los aspectos actuales positivos y negativos de cada país, al igual que establecer el progreso en el desarrollo normativo frente a dicho escenario, para determinar qué Estado ostenta la democracia participativa como forma de gobierno.
Sedentarismo en la población de 18 a 64 años de la ciudad de Pereira, 2020.
Authors: Varona Vidal Luisa Fernanda , Herrera Quintero Carolina , González Santamaría Jhonatan , López García Claudia Jimena
Published: March 2021

Cuando se habla de conductas sedentarias por lo general se habla de aquellas actividades que se realizan estando sentado, acostado o reclinado sin estar dormido. Los comportamientos sedentarios están asociados a enfermedades que generan grandes costos.En la actualidad en Pereira, no se cuenta con un registro actualizado que permita conocer la prevalencia de sedentarismo en la población adulta y en sí, en ningún momento del ciclo vital.Estudio epidemiológico de prevalencia. En el cual la variable de estudio es el comportamiento sedentario en la población entre 18 a 64 años de edad del municipio de Pereira. La población se tomó del DANE en donde se espera que en Pereira viven 74025 en 2020. A partir de allí se calculó una muestra representativa aleatoria de 950 personas, las cuales serán seleccionadas a través de técnicas de georreferenciación.Resultados esperados: generar información útil para la toma de decisiones en salud pública.
La apropiación de la cátedra de la paz a partir de las voces de los estudiantes
Authors: Ramírez Valencia Ricardo , Gutiérrez Hernández David , Vélez Rivera Laura
Published: March 2021

El presente proyecto parte de los enfoques socioculturales, y la mirada de las situaciones educativas como eje integral y no como componentes apartes. Se analiza también los cambios que se generan a partir de la incorporación de las voces de los estudiantes mediante la posibilidad de la participación y elección que puedan tener los estudiantes en sus procesos educativos (Rudduck y Flutter, 2007), además de cómo esto posibilita también la apropiación de los saberes (Rogoff, 1997), en específico de la asignatura cátedra de paz. Este proyecto se pretende realizar desde la Investigación-Acción-Educativa (IAE), en donde se trabaja directamente con las necesidades de la comunidad.
Introduction : Œuvrer ensemble. Les rouages collectifs dans la chaîne du livre
Authors: Boivin Karol'Ann , Fréchette Mylène
Published: March 2021

Dans l’introduction de ce numéro spécial des Cahiers de la Société bibliographique du Canada, Karol’Ann Boivin et Mylène Fréchette soulignent le peu de visibilité dont bénéficient les intermédiaires de la chaîne du livre dans l’espace public. S’ils intéressent de plus en plus les chercheurs, on doit prendre acte de leur relatif effacement dans l’imaginaire. Qui sont ces travailleurs de l’ombre ? Quelle est la portée de leurs actions sur l’objet-livre et, surtout, comment celles-ci se combinent-elles à celles des autres agents de la chaîne? Ce sont les questions qui ont orienté ce numéro spécial, centré sur l’action collective dans le monde du livre. En terminant, les corédactrices présentent les trois articles qui composent le numéro, signés par Philippe Rioux, Mylène Fréchette ainsi que Maxime Bolduc.
Approximate solution of nonlinear differential system with time variation
Authors: Karim Rezaul , Dey Pinakee , Miah Saikh Shahjahan
Published: March 2021

this paper develops a reliable algorithm based on the general Struble’s technique and extended KBM method for solving nonlinear differential systems. Moreover, we find a solution based on the KBM and general Struble’s technique of nonlinear autonomous systems with time variation, which is more powerful than the existing perturbation method. Finally, results are discussed, primarily to enrich the physical prospects, and shown graphically by utilizing MATHEMATICA and MATLAB software.

Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, 121-130, 2020
Late Professor Dr. Quazi Abdul Fattah
Authors: Begum ZN Tahmida
Published: March 2021

Abstract not available

Journal of Bangladesh Academy of Sciences, Vol. 44, No. 2, i-iii, 2020
Comparison of the Effectiveness of Platelet-Rich Plasma (PRP), Hyaluronic Acid and the Combination of Both in the Treatment of Mild and Moderate Osteoarthritis of the Knee
Authors: Shoma Farzana Khan , Rahman Md Mahmudur , Chowdhury Ziaur Rahman , Hassan Muhammad Kamrul , Hossain Farzana , Rahman Farzana , Gomes Lilian Catherene , Ullah Md Ahsan
Published: March 2021

Osteoarthritis (OA) is by far the most common form of arthritis characterized by focal loss of articular cartilage, subchondral osteosclerosis, osteophyte formation at the joint margin, and remodeling of joint contour with enlargement of affected joints. This randomized, clinical trial aimed to compare the effectiveness of Platelet Rich Plasma (PRP) and Hyaluronic Acid (HA) as individual treatments and PRP in combination with HA in the treatment of mild to moderate knee Osteoarthritis (OA). The study was conducted among 89 patients with mild to moderate knee osteoarthritis in the Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh. Patients were randomly allocated to one of the three interventions: HA (n=30), PRP (n=30), or HA+PRP (n=29). Patients in HA group received 3 intra-articular knee injections with 1 week interval while patients in PRP group and PRP+HA group received 2 intra-articular knee injections with 2 week interval. Functional outcome of the treatment were evaluated using the Western Ontario and McMaster Universities Arthritis Index (WOMAC) and Visual Analogue Scale (VAS) questionnaire at baseline and after 1,3,6 and 9 months of treatment. Majority of the patients in all groups were female where mean age of the patients were about 50 years. Pain scores in VAS scale significantly reduced in PRP group when compared to HA group and also in PRP+HA when compared to HA group which persist till nine months (p<0.05). No significant statistical difference was found in VAS scores between PRP and PRP+ HA group. WOMAC pain scores also significantly reduced in PRP group when compared to HA group and also in PRP+HA when compared to HA group (p<0.05). WOMAC stiffness significantly reduced in PRP+ HA group when compared to HA group at three month (p<0.001) and at six month (p=0.011). At nine month, physical activity scores significantly reduced in PRP group compared to HA group (p=0.002) and in PRP+HA when compared to HA group (p<0.001). No significant reduction was observed in WOMAC scores when the outcome of PRP+HA was compared with PRP alone. PRP provides better functional outcome than HA. The combination of PRP and HA also provides better outcome than HA alone but does not provide better outcome than PRP alone.

J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 172-178
Life–Threatening Hyperkalemia Presenting with Cardiac Arrest during Combined Therapy with Angiotensin – Converting Enzyme Inhibitor and Spironolactone: a Case Report
Authors: Chakraborty Shudipan , Khayer MA , Rahman Mahbubor
Published: March 2021

A 56-year-old man with history of previous coronary artery bypass graft (CABG) surgery and prior history of mild renal impairment was brought to the emergency department at mid night in gasping state. On presentation his pulse and blood pressure (BP) were non recordable. Cardiopulmonary resuscitation (CPR) was started immediately and he was intubated in the emergency room. Within few minutes his pulse became perceptible but BP still remained non recordable. His bed side 12 leads electrocardiogram (ECG) revealed sine wave configuration,suggestive of severe hyperkalemia with heart rate 30-35 beats per minute (bpm).Urgently he was transferred to cardiac catheterization laboratory for temporary pacemaker insertion (TPI). After putting TPI he regained consciousness and BP raised to normal. His blood gas analysis showed severe hyperkalemia (Serum potassium level-9.4 mmol/L). In coronary care unit (CCU) he was commenced on standard treatment of hyperkalemia and his electrolyte imbalance normalized within 24 hours. His cardiac rhythm reverted back to sinus within 24 hours of admission and he was extubated next day and discharged from the hospital after 5 days in a relatively stable state.

J Dhaka Medical College, Vol. 28, No.2, October, 2019, Page 212-215
Analisis Pengaruh Pembiayaan Bank Syariah, Investasi dan Belanja Pemerintah terhadap Pertumbuhan Ekonomi di Indonesia
Authors: Jamili Mubasyir
Published: March 2021

Penelitian ini membahas hubungan antara Pembiayaan Bank Syariah, Investasi dan Belanja Pemerintah terhadap Pertumbuhan Ekonomi di Indonesia dengan menggunakan data time series dan data cross section. Tujuan penelitian adalah melihat pengaruh besarnya Pembiayaan Bank Syariah, Investasi dan Belanja Pemerintah di Indonesia terhadap Pertumbuhan Ekonomi di Indonesia (2010-2014). Dalam penelitian ini, Pertumbuhan Ekonomi digambarkan dengan PDRB per provinsi di Indonesia. Penelitian adalah penelitian kuantitatif dengan metode Regresi Linier Berganda dan Ordinary Least Square (OLS). Hasil penelitian menunjukkan bahwa Pembiayaan Bank Syariah dan Belanja Pemerintah signifikan mempengaruhi Pertumbuhan ekonomi di Indonesia. Investasi tidak signifikan mempengaruhi Pertumbuhan Ekonomi di Indonesia.
Proses Entrepreneurship, Kolaborasi Inovasi, Penciptaan Kekayaan di Dalam Organisasi Bisnis
Authors: Nizar Muhammad
Published: March 2021

Proses kewirausahaan diawali dengan adanya inovasi. Inovasi tersebut dipengaruhi oleh berbagai faktor baik yang berasal dari dalam maupun dari luar seperti pendidikan, sosiologi, organisasi, kebudayaan, dan lingkungan. Tujuan penelitian ini, untuk mendorong sebuah organisasi bisnis, untuk lebih berkembang dalam rangka menciptakan kesuksesan di sebuah usaha/ lembaga, khususnya perbankan syariah. Penelitian ini menggunakan desain penelitian deskriptif yang bertujuan untuk meneliti, mengevaluasi dan memberdayakan proses entrepreneurship, kolaborasi inovasi dan penciptaan kekayaan di dalam organisasi bisnis.
Teoria de Filas e Rede de Petri Estocástica: Um tutorial
Authors: Lima John Wesley Soares de , Callou Gustavo , Andrade Ermeson
Published: March 2021

A teoria das filas estuda sistemas que exigem que os clientes ou objetos esperem. Por     outro lado, as redes de Petri                 são um formalismo matemático usado para modelar, analisar e otimizar sistemas complexos. Embora a teoria das filas                 tenha sido amplamente usada na literatura, ela não pode ser usada para modelar certos comportamentos de sistemas                 complexos como dependências entre componentes ou comportamento de falha e reparo. Assim, este tutorial tem como                 objetivo apresentar ao leitor o vocabulário e as construções de modelos de redes de Petri e ilustrar a equivalência   desses modelos a sistemas de filas por meio de um conjunto de exemplos. Os resultados estatísticos obtidos via   simulação revelaram que os modelos de rede de Petri podem representar sistemas de filas. Além disso, esperamos que        este tutorial sirva de complemento às limitações da teoria das filas e ajude pesquisadores ou profissionais, tanto da               academia quanto da indústria, a modelarem sistemas complexos com base nos exemplos apresentados neste trabalho.
Desenvolvimento e caracterização de snack de milho extrusado com adição de farinha de ora-pro-nóbis
Authors: Francelin Maria Fernanda , Machado Leonardo Martins , Silva Denise de Moraes Batista da , Alves Eloize da Silva , Peralta Rosane Marina , Costa Silvio Claudio , Monteiro Antônio Roberto Giriboni
Published: March 2021

A ora-pro-nóbis faz parte de um grupo de hortaliças não convencionais que não são encontradas em cardápios usualmente devido à falta de conhecimento da população a respeito de seus benefícios nutricionais. No entanto, as plantas alimentícias não convencionais se destacam como alimentos funcionais devido a vitaminas, antioxidantes, fibras, proteína e sais minerais encontradas em plantas, como é o caso da ora-pro-nóbis. O presente trabalho teve o objetivo de elaborar um snack de milho extrusado com adição de farinha de folhas de ora-pro-nóbis (OPN) da espécie Peréskia grandifolia Haw (PG), visando aumentar o valor nutritivo deste produto e avaliar sua aceitação sensorial perante a avaliadores não treinados. A colheita, higienização e desidratação, foram efetuadas para a obtenção da farinha das folhas. Posteriormente, esta farinha foi submetida a análises bromatológicas de rotina como umidade, proteínas, lipídios, cinzas, ferro e fibras tendo resultados próximos aos encontrados na literatura. Com a farinha das folhas foram desenvolvidas duas formulações com adição de 10 e 20% de farinha de folhas respectivamente, juntamente com um padrão de composição de 100% grits de milho. Os produtos prontos foram submetidos as mesmas análises bromatológicas anteriormente citadas, além de uma análise sensorial de aceitação por escala Hedônica com provadores não treinados. O suplemento desenvolvido de folhas de ora -pro-nóbis apresentou alto valor biológico em proteínas em fibras além de uma boa aceitação, mostrando-se viável sua utilização.
Efeito dos bagaços de malte e cana-de-açúcar na retenção de nutrientes em substratos de telhado verde extensivo
Authors: Scarassatti Marcella Regyna do Nascimento , Benatti Aline , Morais Eduardo Beraldo de
Published: March 2021

Este estudo objetivou avaliar a qualidade da água escoada por unidades experimentais de telhados verdes contendo substratos acrescidos de materiais adsorventes de baixo custo, como o bagaço de malte (M) e o bagaço de cana-de-açúcar (C). Cada unidade experimental foi composta por manta do tipo geotêxtil, um substrato e a vegetação (Arachis repens). Os substratos M e C foram comparados com um substrato controle (CON) de grande utilização comercial. O experimento foi desenvolvido em duas etapas, irrigação manual e chuva real. A qualidade da água escoada pelas unidades experimentais foi analisada por meio dos parâmetros de cor verdadeira, turbidez, sólidos totais, pH, condutividade elétrica, nitrato , fosfato  e sulfato . As diferenças nos substratos exerceram efeitos significativos nas concentrações de  e , sendo o substrato C com melhor desempenho na retenção destes ânions. A distribuição e o impacto da água nas unidades experimentais apresentaram diferenças quanto ao carreamento de nutrientes, com menor lixiviação na fase de irrigação manual. Os resultados sugerem que a aplicação do bagaço de cana-de-açúcar em telhados verdes para a melhoria da qualidade da água escoada é promissora.
Complicações decorrentes da infecção congênita pelo Zika Vírus
Authors: Silva Samilo Jarlys Brito da , Teixeira Linda Thaís de Oliveira , Cardoso Lânia da Silva , Costa Gabriela Oliveira Parentes da , Nascimento Lília Regina de Lima Cardoso , Marques Evellyn Stefanne Bastos , Rezende Verônica Elis Araújo , Castro Mara Cléssia de Oliveira , Rosal Verônica Maria de Sena , Silva Fernanda Mendes Dantas e , Monteiro Lorena Di Mayo Guedes , Mascarenhas Leonardo Teles Martins , Carvalho Francisca Áurea Portela Martins , Cardoso Galvaladar da Silva , Ribeiro Aclênia Maria Nascimento
Published: March 2021

Objetivo: Investigar na literatura nacional e internacional, as evidências acerca das complicações decorrentes da infecção congênita pelo Zika Vírus. Metodologia: Trata-se de uma revisão integrativa da literatura realizada nas bases de dados: Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medical Literature Analysis and Retrieval System Online (MEDLINE/PUBMED), Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS) e Web of Science (WoS), no mês de fevereiro de 2021. Para a definição dos critérios de inclusão foi selecionado o recorte temporal de 2016 a 2020, artigos originais, disponíveis na íntegra, gratuitos e online nas bases de dados selecionadas e publicados nos idiomas português, inglês e espanhol. Adotou-se como critérios de exclusão: artigos que estivessem em duplicidade nas bases de dados ou artigos em que não foi possível identificar relação com a temática por meio da leitura de títulos e resumos. Resultados e discussão: A partir das buscas nas bases de dados e aplicação dos critérios de elegibilidade, foram incluídos 09 estudos na revisão, que após a sua análise foi verificado que a infecção pelo Zika Vírus é considerada como um grave problema de saúde pública devido a associação com o aumento da incidência aparente de microcefalia em recém-nascidos de mães infectadas pelo vírus, bem como outras complicações associadas que pode afetar sobremaneira o indivíduo acometido, tais como: diminuição do volume cerebral, ventriculomegalia, hipoplasia cerebelar, lisencefalia com hidrocefalia e sequência de deformação da acinesia, além de problemas oculares e auditivo, contraturas articulares e disfagia. Conclusão: Nessa perspectiva, percebe-se a necessidade da formulação e implementação de medidas de controle ao vetor da doença, considerando cada cenário, de forma a prevenir a transmissão dessa doença, em especial, às gestantes, evitando assim, a transmissão congênita.
Trastornos del aprendizaje y epilepsia
Authors: Rocha Junior Fernando César de Medeiros , Alencar Pereira Glauber José , Santos Hyorrana Rayanne de Oliveira , Oliveira Renata Manoela Rocha de , Pedroso Rodríguez María de los Ángeles , López Seidel Guerra
Published: March 2021

La epilepsia es un trastorno cerebral caracterizado por una predisposición continuada a la aparición de crisis epilépticas y por las consecuencias neurobiológicas, cognitivas, psicológicas y sociales de esta enfermedad. La definición de epilepsia requiere la presencia de al menos una crisis epiléptica. Los niños con epilepsia tienen mayor riesgo de tener trastornos del aprendizaje en comparación con los niños sanos y con aquellos que presentan otras enfermedades crónicas de la infancia. Se realizo una revisión narrativa de la literatura, incluyendo artículos indexados en las plataformas digitales, Literatura Latino-Americana e do Caribe em Ciencias da Saúde (LILACS), Health Information from the National Library of Medicine (Medline), Web of Science, en la biblioteca electrónica Scientific Eletronic Library On-line (SciELO), y PubMed, publicados en el periodo comprendido entre los años 2017 y 2020. Los trastornos de aprendizaje son más frecuentes entre los niños con epilepsia, con un predomino significativo en el sexo masculino; la Epilepsia Rolándica es la que presenta mayor asociación con los trastornos del aprendizaje; el inicio más temprano de las convulsiones está relacionado con mayor deterioro cognitivo y existe una alta comorbilidad entre la epilepsia, los Trastornos por Déficit de Atención e Hiperactividad y los trastornos generalizados del aprendizaje.
DEVELOPING PERSONAL COMPETENCY TEST INSTRUMENTS IN IDENTIFYING ATTITUDE OF RADICALISM
Authors: Syah Rahmat , - Lusiana
Published: March 2021

Era globalisasi radikalisme berkembang dengan pesatnya, khususnya melalui jejarang sosial yang digunakan oleh Siswa Menengah Atas dan Mahasiswa. Perlunya pengukuran sikap radikalisme  mahasiswa untuk mengetahui gambaran karakter dari mahasiswa agar pihak institusi dapat melakukan pencegahan atau pembinaan. Penelitian ini bertujuan untuk mengambangkan instrumen  tes masuk perguruan tinggi khususnya tes masuk di IBM asmi. Instrumen yang dikembangkan adalah instrumen  Tes Karakteristik Pribadi (TKP) yang dapat mengidentifikasi sikap radikalisme. Metode penelitian menggunakan penelitian pengembangan R & D dengan pendekatan kualitatif dan kuantitatif. Instrumen yang dikembangkan dibuktikan validitasnya secara isi dengan expert judgement dari para ahli pengukuran dan dibuktikan dengan validitas konstruk dengan analisis konformatori serta dilakukan pembuktian reliabelitas. Hasil penelitian ini yaitu instrumen pengukuran sikap radikalisme valid dan reliabel serta dapat mengidentifikasi sikap radikalisme untuk mahasiswa. Terdapat 5 dimensi sikap radikalisme dari mulai agama, keluarga, kepribadian, pandangan politik dan relasi sosial.Focus Group Discussion menghasilkan 5 dimensi dan 13 indikator serta 35 butir item yang dapat digunakan untuk pengukuran sikap radikalisme mahasiswa. Hasil uji validitas terdapat 2 item yang perlu diperbaiki. Hasil reliabelitas pada instrumen  yang dikembangkan tergolong tinggi dan instrumen siap digunakan.
THE EFFECT OF THE TTW MODEL ASSISTED BY CONCRETE MEDIA ON LEARNING OUTCOMES OF CLASS V ELEMENTARY SCHOOLS
Authors: Hidayah Nurul , Supratno Haris , Rochmania Desty Dwi
Published: March 2021

The problem that is the focus of this research is the effect of using the TTW model assisted by concrete media in thematic learning. This study aims to determine the results of the pretest and posttest in learning using the TTW model assisted by concrete media in the experimental group and the results of the pretest and posttest without applying the TTW model assisted by concrete media, and to provide an overview of the effect of using the TTW model assisted by concrete media on student learning outcomes. in thematic learning class V SDN 3 Craken. This study used an experimental method using the nonequevalent control group design with a comparative analysis technique. The data collection in this study used a written test, in which the pretest-posttest questions were similar questions made by researchers independently by passing the Likert validation test that had been carried out by lecturers and class teachers. The data analysis technique used is the T-test with normality test and hypothesis testing. For the pretest experimental group normality test 0.200 <0.375 and 0.075 <0.375 posttest, then the pretest control group normality test 0.200 <0.375 and the posttest 0.151 <0.375, which can be concluded that the two data are normally distributed. And to test the experimental group's hypothesis obtained T count 8.437 which this score is higher than the T table 2.201. Thus it can be said that Ho is rejected and Ha is accepted. From these results it can be concluded that the learning achievement before and after using the think talk write model assisted by concrete media is different.
IMPLEMENTATION OF DISCIPLINE CHARACTER EDUCATION FOR STUDENT THROUGH ACTIVITIES OF BOY SCOUT EXTRACURRICULAR
Authors: Fitri Rini Ainur , Kamidjan Kamidjan , Wiyadi Heru
Published: March 2021

The Indonesian nation has recently experienced a decline in the quality of the nation’s character, especially in discipline so that it is necessary to plant and apply character education as early as possible to children. One of the excellent extracurricular activities to form the character of student discipline is the scouting activity. The purpose of this study was to find out and describe the process of implementing student discipline character education through scout extracurricular activities. The approach used is qualitative descriptive type with data collection techniques using interview, observation, questionnaire and documentation. Data analysis in this research was carried out by collecting data, reducing data, presenting data and drawing conclusions. The results of this study, in the process of implementing disciplined character education through scouting activities namely by giving examples of exemplary attitudes to students, not giving physical punishment, teaching and learning activities carried out using the principle of spring but humor. The results of the process of implementing disciplined character education for students by using the interview and observation methods are more controlled attitude of delinquency on student, more discipline on time, self discipline, discipline in asking permission, discipline in obyeing school rules. While from the questionnaire method the results obtained are that the discipline implemented through scout activities is in the category of very disciplined with the percentage system 93,16%.
THE EFFECT OF DISCOVERY LEARNING BASED 3D SCRAPBOOK MEDIA TOWARD MOTIVATION AND LEARNING OUTCOMES
Authors: Sari Dian Ratna , Kamidjan Kamidjan , Raharja Hawwin Fitra
Published: March 2021

Discovery learning learning model is an effective model for advancing student motivation and learning outcomes. The aim of this research is to understand the effect of discovery learning model based on 3D scrapbook media on building material on student motivation and learning outcomes of fifth grade students at SDN Munungkerep II Kabuh. This type of research uses a quantitative approach, the research design that is used is the post-test only control design. The population in this study was fifth grade students of SDN Munungkerep Kabuh Jombang with saturated sampling techniques. The data analysis techniques that are used are validity test, normality test, and multivariate variant test (MANOVA). The results showed that (1) The application of discovery learning model based on 3D scrapbook media on space building material influenced the motivation of class students based on a significant value of 0.193 ≥ 0.05, (2) The application of discovery learning model based on 3D scrapbook media on space building material affect the learning outcomes of class students based on a significant value of 0.246 ≥ 0.05, and (3) The application of discovery learning models using 3D scrapbook media on building materials has an effect on motivation and student learning outcomes based on a significant value of 0.433 ≥ 0.05.
THE INFLUENCE OF SNAKE AND LADDER GAME MEDIA ON LEARNING OUTCOMES OF GRADE III ELEMANTARY SCHOOL STUDENTS
Authors: Rohmania Faridatur , Supratno Haris , Siswanto M. Bambang Edi
Published: March 2021

Based on the results of observations, it was found that sevral problems when learning took place, it was seen that learning activities tended to be possive due to the lack of selection of innovative learning strategies. The purpose of this study was to determine the effect of learning using the snake and ladder game media and conventional learning on the learning outcomes of grade III students at SDN Gongseng I Megaluh Jombang in academi year 2019/2020. This study was a pre-experimental design with an intact group comparison design. The population in this study were all students of class III SDN Gongseng I Megaluh, totaling 24 students. While the sample used is a full sample with 12 students as the control group and 12 students as the experimental group. Data collection through tests. The data analysis used was t-test analysis. The results of t-test analysis obtained tobs > ttab (4.39 > 2.17), so Ho was rejected and Ha was accepted. So it can be said that there is an influence on learning using the snake and ladder game media in grade III SDN Gongseng I Megaluh in the 2019/2020 scholl year. This defference can also be seen from the average acquisition of learning outcomes in the experimental group and the control group. The experimental group obtained a higher average value than the control group (81,6 > 60,8). This can prove that the use of the snake and ladder game media has a positive effect on the learning outcomes of grade III student at SDN Gongseng I Megaluh in academic year 2019/2020.
Downregulation of Macrophage-Specific Act-1 Intensifies Periodontitis and Alveolar Bone Loss Possibly via TNF/NF-κB Signaling
Authors: Pathak Janak L. , Fang Ying , Chen Yunxin , Ye Zhitong , Guo Xueqi , Yan Yongyong , Zha Jun , Liang Dongliang , Ke Xiuxian , Yang Luxi , Zhong Wenchao , Wang Lijing , Wang Liping
Published: March 2021

Periodontitis is a chronic inflammatory oral disease that affects almost half of the adult population. NF-κB activator 1 (Act1) is mainly expressed in immune cells, including macrophages, and modulates immune cells’ function to regulate inflammation in inflammatory diseases. Macrophages play a vital role in the pathophysiology of periodontitis. However, the effect of macrophage-specific Act1 on periodontitis has not been investigated yet. This study aims to unravel the role of macrophage-specific Act1 on the pathophysiology of periodontitis. The expression of Act1 in healthy and periodontitis periodontal tissue was confirmed by immunohistochemistry. Macrophage-specific Act1 expression downregulated (anti-Act1) mice were developed by inserting anti-Act1 antisense oligonucleotides after the CD68 promoter of C57BL/6 mice. Ligature-induced periodontitis (LIP) was induced in anti-Act1 mice and wildtype mice. Micro-CT, histology, and TRAP staining analyzed the periodontal tissue status, alveolar bone loss, and osteoclast numbers. Immunohistochemistry, RT-qPCR, and ELISA analyzed the inflammatory cells infiltration, expression of inflammatory cytokines, and M1/M2 macrophage polarization. mRNA sequencing of in vitro bacterial lipopolysaccharide (LPS)-treated peritoneal macrophages analyzed the differentially expressed genes in anti-Act1 mice during inflammation. Anti-Act1 mice showed aggravated periodontitis and alveolar bone loss compared to wildtype. Periodontitis-affected periodontal tissue (PAPT) of anti-Act1 mice showed a higher degree of macrophage infiltration, and M1 macrophage polarization compared to wildtype. Levels of pro-inflammatory cytokines (IL-1β, IL-6, and TNFα), and macrophage activity-related factors (CCL2, CCL3, and CCL4) were robustly high in PAPT of anti-Act1 mice compared to wildtype. mRNA sequencing and KEGG analysis showed activated TNF/NF-κB signaling in LPS-treated macrophages from anti-Act1 mice. In vitro studies on LPS-treated peritoneal macrophages from anti-act1 mice showed a higher degree of cell migration and expression of inflammatory cytokines, macrophage activity-related factors, M1 macrophage-related factors, and TNF/NF-κB signaling related P-p65 protein. In conclusion, downregulation of macrophage-specific Act1 aggravated periodontitis, alveolar bone loss, macrophage infiltration, inflammation, and M1 macrophage polarization. Furthermore, LPS-treated macrophages from anti-Act1 mice activated TNF/NF-κB signaling. These results indicate the distinct role of macrophage-specific Act1 on the pathophysiology of periodontitis possibly via TNF/NF-κB signaling.
The Evolutionary Conserved SWI/SNF Subunits ARID1A and ARID1B Are Key Modulators of Pluripotency and Cell-Fate Determination
Authors: Pagliaroli Luca , Trizzino Marco
Published: March 2021

Organismal development is a process that requires a fine-tuned control of cell fate and identity, through timely regulation of lineage-specific genes. These processes are mediated by the concerted action of transcription factors and protein complexes that orchestrate the interaction between cis-regulatory elements (enhancers, promoters) and RNA Polymerase II to elicit transcription. A proper understanding of these dynamics is essential to elucidate the mechanisms underlying developmental diseases. Many developmental disorders, such as Coffin-Siris Syndrome, characterized by growth impairment and intellectual disability are associated with mutations in subunits of the SWI/SNF chromatin remodeler complex, which is an essential regulator of transcription. ARID1B and its paralog ARID1A encode for the two largest, mutually exclusive, subunits of the complex. Mutations in ARID1A and, especially, ARID1B are recurrently associated with a very wide array of developmental disorders, suggesting that these two SWI/SNF subunits play an important role in cell fate decision. In this mini-review we therefore discuss the available scientific literature linking ARID1A and ARID1B to cell fate determination, pluripotency maintenance, and organismal development.
Toward a Consensus in the Repertoire of Hemocytes Identified in Drosophila
Authors: Cattenoz Pierre B. , Monticelli Sara , Pavlidaki Alexia , Giangrande Angela
Published: March 2021

The catalog of theDrosophilaimmune cells was until recently limited to three major cell types, based on morphology, function and few molecular markers. Three recent single cell studies highlight the presence of several subgroups, revealing a large diversity in the molecular signature of the larval immune cells. Since these studies rely on somewhat different experimental and analytical approaches, we here compare the datasets and identify eight common, robust subgroups associated to distinct functions such as proliferation, immune response, phagocytosis or secretion. Similar comparative analyses with datasets from different stages and tissues disclose the presence of larval immune cells resembling embryonic hemocyte progenitors and the expression of specific properties in larval immune cells associated with peripheral tissues.
The Abnormal Glycopatterns of Salivary Glycoproteins in Esophageal Squamous Cell Carcinoma Patients
Authors: Shu Jian , Ma Jun , Ren Xiameng , Wang Jian , Wang Yan , Zhang Kun , Yu Hanjie , Guo Xiangqian , Li Zheng
Published: March 2021

Glycosylation is one of the most crucial posttranslational modifications of proteins, containing a remarkable amount of biological information. The alteration of glycosylation is closely associated with certain diseases. Exploring glyco-code in the development of diseases is a hot topic in recent years. Esophageal squamous cell carcinoma (ESCC) is the primary pathological histology in developing countries and a severe threat to human health. Although the glycan profiles in the blood samples of ESCC patients were analyzed using glycomic and glycoproteomic methods, the difference of salivary glycopatterns between healthy subjects and ESCC patients is not explicit yet. In the present study, ESCC patients (n = 16) and healthy volunteers (HVs, n = 25) were enrolled. The glycomic strategy combining lectin microarray and lectin blotting was employed to investigate and confirm the altered salivary glycopatterns. Datura stramonium (DSA) was selected to isolate the GlcNAc or Galβ1-4GlcNA-containing glycoproteins due to the distinct difference between ESCC patients and HVs. The N-glycans from DSA-enriched glycoproteins were released by PNGase F and further identified by MALDI-TOF/TOF-MS to obtain the precise structural information of the altered glycans. As a result, the glycopatterns recognized by 13 lectins (e.g., ECA, RCA120, and DSA) showed significant alterations in ESCC patients’ saliva. The ESCC patients showed higher levels of GalNAc and Gal, sialic acid, and GlcNAc expression profiles and lower levels of mannose and fucose expression profiles. The MALDI-TOF/TOF-MS results indicated that the proportion of the GlcNAc or Galβ1-4GlcNAc-containing N-glycans was increased in ESCC patients (79.04%) compared with HV (63.20%), which was consistent with the results of lectin microarrays. Our findings provide comprehensive information to understand the complex physiological changes in ESCC patients. And the altered salivary glycopatterns such as GlcNAc or Galβ1-4GlcNAc-containing N-glycans recognized by DSA might serve as potential biomarkers for the diagnosis of ESCC patients.
Anaplasma phagocytophilum Induces TLR- and MyD88-Dependent Signaling in In Vitro Generated Murine Neutrophils
Authors: Müller Beate J. , Westheider Arne , Birkner Katharina , Seelig Birte , Kirschnek Susanne , Bogdan Christian , von Loewenich Friederike D.
Published: March 2021

Anaplasma phagocytophilum is a tick-transmitted obligate intracellular Gram-negative bacterium that replicates in neutrophils. It elicits febrile disease in humans and in animals. In a mouse model, elimination of A. phagocytophilum required CD4+ T cells, but was independent of IFN-γ and other classical antibacterial effector mechanisms. Further, mice deficient for immune recognition and signaling via Toll-like receptor (TLR) 2, TLR4 or MyD88 were unimpaired in pathogen control. In contrast, animals lacking adaptor molecules of Nod-like receptors (NLR) such as RIP2 or ASC showed delayed clearance of A. phagocytophilum. In the present study, we investigated the contribution of further pattern recognition receptor (PRR) pathways to the control of A. phagocytophilum in vivo. Mice deficient for the NLR NOD2 had elevated bacterial loads in the early phase of infection, but were unimpaired in pathogen elimination. In contrast, animals lacking adaptor proteins of different C-type lectin receptors (CLR) such as DAP12, Fc-receptor γ-chain (FcRγ) and SYK controlled A. phagocytophilum as efficiently as wild-type mice. Further, we investigated which PRR pathways are involved in the sensing of A. phagocytophilum by in vitro generated Hoxb8 murine neutrophils. In vitro, recognition of A. phagocytophilum by murine neutrophils was dependent on TLR- and MyD88 signaling. However, it remained intact in the absence of the NLR NOD1, NOD2 and NALP3 and of the CLR adaptor molecules DAP12 and FcRγ. From these results, we conclude that TLR rather than NLR or CLR are critical for the detection of A. phagocytophilum by neutrophils although in vivo defective TLR-signaling is compensated probably because of the redundancy of the immune system.