bluuebunny/crossref_metadata_2025 huggingface dataset:
Coat colour mismatch improves survival: energetic advantages exceed lost camouflage
Authors: Kennah Joanie , Peers Michael , Wal Eric Vander , Majchrzak Yasmine , Menzies Allyson , Studd Emily , Boonstra Rudy , Humphries Murray , Jung Thomas , Kenney Alice , Krebs Charles , Boutin Stan
Published: January 2024

Climate warming is causing asynchronies between animal phenology and
environments. Mismatched traits, like coat colour change mismatched with
snow, typically decrease survival. However, coat change does not serve a
singular adaptive benefit of camouflage, and alternate coat change
functions may confer advantages that supersede mismatch costs. We found
that mismatch reduced autumn mortality risk of snowshoe hares in the
Yukon by 86.5 %. We suggest that the increased coat insulation and
lower metabolic rates of winter acclimatized hares confer energetic
advantages to white mismatched hares that reduce their risk of dying. We
found that white mismatched hares forage 17-77 minutes less per day than
matched brown hares between 0 and -10 ºC, thus lowering their predation
risk and increasing survival. We found no effect of mismatch on spring
mortality risk, where mismatch occurred at warmer temperatures,
suggesting a potential temperature limit where the costs of
conspicuousness outweigh energetic benefits.
The risk of relapse for adult-onset Still’s disease: A retrospective study of 56 patients
Authors: Li Sheng , Tang Shunli , Ying Shuni , Liu Taoming , Fang Hong , Qiao Jianjun
Published: January 2024

Objective: Adult-onset Still’s disease (AOSD) is a multisystem
autoinflammatory disorder characterized by a high spiking fever,
arthralgia or arthritis, skin rash, leukocytosis, and hyperferritinemia.
The relapse rate is high, from 40% to 50%. Our objective was to
retrospectively analyze the risk of relapse for AOSD. Methods:
Retrospective data of patients diagnosed with AOSD in our institute
during 2013-2018 were analyzed. The diagnoses were based on the
Yamaguchi criteria for AOSD. All long-term follow-up data were collected
from medical records and phone calls. Results: In total, 56 patients
with AOSD were included in this study. The mean age of the patients was
39.2 ± 14.2 years, and 37 patients (66.1%) were female. Twenty-three
patients (41.1%) had experienced at least one relapse of AOSD. The
factors associated with relapse were increased levels of lactic
dehydrogenase (LDH) (OR = 1.003, P = 0.044) and creatine
kinase-myocardial band (CK-MB) (OR = 1.111, P = 0.032). Conclusion: AOSD
patients with elevated serum levels of LDH and CK-MB were more likely to
have relapses, these prognostic factors may be helpful for the clinical
management of AOSD patients.
Heterostructure Ni(OH)2/ZrO2 catalyst can achieve efficient oxygen reduction reaction
Authors: Li Ruimin , Zhang Rong , Qiao Yalei , Zhang Ding , Cui Zixiang , Wang Wenyang
Published: January 2024

It is still a huge challenge to find nonnoble-metal oxygen reduction
reaction (ORR) catalysts that can replace Pt. Here, we report a
heterostructure Ni(OH)2/ZrO2 catalyst made in one step using a simple
alcohol thermal method that has the same onset potential (0.84 V) and
overpotential (390 mV) as 20% Pt/C, abundant active sites, low Tafel
slope (57 mV dec–1), good stability and excellent methanol tolerance.
Moreover, we found that ZrO2 has a great influence on Ni(OH)2 through
its abundant oxygen vacancies and inhibits the oxidation of Ni2+.
However, the nature of its excellent catalytic performance is still
unclear, so we analyzed it using a density functional theory (DFT)
calculation. In particular, we studied the heterostructure Ni(OH)2/ZrO2
due to the abnormal synergistic effect of charge transfer and
heterostructure interface and stabilized O radicals using ZrO2, which
promoted the spontaneous progress of the Ni(OH)2/ZrO2 ORR, thereby
improving the catalytic performance.
Risk Factors for Acute Kidney Injury due to Severe Hypothyroidism
Authors: Batman Adnan , Canat Muhammed Masum , Saygili Emre Sedar , Besler Ender , Yildiz Duygu , Ozturk Feyza Yener , Altuntas Yuksel
Published: January 2024

Objective This study aims to investigate the factors affecting
development of acute kidney injury (AKI) due to severe hypothyroidism.
Methods This single-centre, retrospective observational study involved
patients with primary hypothyroidism and thyroid stimulating hormone
(TSH) levels of more than 50 mIU/L at their review in the endocrinology
outpatient clinic, between January 2015 and April 2021. Patients whose
medical history and laboratory data were complete were included in the
study. Demographic and laboratory data of patients with AKI (case group)
and without (control group) were compared. Factors affecting the
development of AKI were examined by logistic regression analysis.
Results A total of 100 patients, 20 (11 male (M), 9 female (F)) in the
AKI (case) group and 80 (23 M, 57 F) patients in control group, were
included in our study. The median age of the case group (56 years,
interquartile range (IQR) 44.3–68.5) was significantly higher than the
control group (49 years, IQR 32.3–60; p = 0.027), and the ratio of
males to females was significantly higher in the case group (p = 0.001).
Multivariate logistic regression analyses showed that hypothyroidism
diagnosed after the age of 60 years (odds ratio (OR) 59.674, 95%
confidence intervals (CI) 5.955–598.031; p = 0.001), free
triiodothyronine (FT3) < 1.3 pg/mL (OR 17.151, 95% CI
2.491–118.089; p = 0.004) and creatine kinase (CK) > 1000
U/L (OR 1.522, 95% CI 1.602–82.848; p = 0.015) were predictors for the
development of AKI due to severe hypothyroidism. Conclusion We recommend
close follow-up and monitoring of patients with AKI caused by severe
hypothyroidism if aged > 60 years, CK > 1000
U/L or FT3 < 1.3 pg/mL.
EVALUATION OF THE FILATION TEAM IN TERMS OF EMPLOYEE SATISFACTION AND ANXIETY-DEPRESSION SCALE IN THE PANDEMIA PROCESS
Authors: paksoy nur , KOTAN DİLCAN
Published: January 2024

Objective: In the effective fight against SARS Cov-2 cases, which have
started to be seen in our country since March 2020, the filiation
studies conducted for resource detection and contact isolation
facilitated the control of the epidemic and increased the success in
epidemic control in the early period. After the definitive case
detection, contact and close contact persons are detected by the
filiation teams, and when necessary, these persons are tested and
asymptomatic individuals are followed up by family physicians for 14
days. Method: For the evaluation, the Employee Satisfaction Scale and
the Health Anxiety Scale (short version) Hospital Anxiety and Depression
Scale (HAD), organized by the Ministry of Health, were used. Study data
were collected using face-to-face interview technique. Results: Employee
satisfaction in the pandemic was found to be moderate, and the risk of
anxiety in women was higher than in men (p <0.05). There was
no relatıon depression risk for both sexes (p> 0.05).
Conclusions: Employee satisfaction in the pandemic was found to be
moderate, and the risk of anxiety was higher in women than in men. No
significant increase in depression risk has been reported in either sex.
Multi-center studies with large participants are needed on this subject.
Electron counting in cationic and anionic silver clusters doped with a 3d transition-metal atom: Endohedral vs. exohedral geometry
Authors: Minamikawa Kento , Sarugaku Shun , Arakawa Masashi , Terasaki Akira
Published: January 2024

Electron counting is an important concept that often governs properties
such as stability of molecules, clusters, and complexes. Here we explore
silver clusters doped with a transition-metal atom, where the behavior
of d electrons has been an issue, i.e., whether or not they delocalize
to participate in electron counting. The present study is performed on
cations and anions of AgNM+/− (M = Sc–Ni) clusters to examine their
stability through reaction with oxygen, which enables systematic control
of the number of valence electrons in the system by the cluster size,
the charge state, and the transition-metal element across the periodic
table. Among 18-valence-electron clusters, both cations and anions
exhibit exceptional stability upon Sc, Ti, and V doping, whereas only
cations upon Fe, Co, and Ni doping; i.e., Ag16Sc+, Ag15Ti+, Ag14V+,
Ag14Sc−, Ag13Ti−, Ag12V−, Ag11Fe+, Ag10Co+, and Ag9Ni+ are identified as
magic clusters. The exceptional stability is attributed to
electronic-shell closure with the 18 valence electrons, where 3d
electrons are delocalized to contribute to electron counting. In
contrast, Ag9Fe−, Ag8Co−, and Ag7Ni− are highly reactive even though
they possess 18 valence electrons. Analysis of reaction products along
with DFT calculations reveals that the transition-metal atom is
endohedrally doped in the former magic clusters, whereas the doping is
exohedral in the latter reactive species. It is thus found that an
endohedral geometry plays a key role in delocalizing 3d electrons to
participate in electron counting. Note that, upon Cr and Mn doping, the
half-filled nature forces their 3d electrons to be localized both in
endohedral Ag13Cr+ and Ag12Mn+ and in exohedral Ag11Cr− and Ag10Mn−.
Products, Pathways, and Kinetics for Catalytic Hydrodenitrogenation of Quinoline in Hydrothermal Condition
Authors: Xie Dan , Liu Xu , Guo Yang
Published: January 2024

This study focuses on mechanism and kinetics in catalytic
hydrodenitrogenation(HDN) of quinoline under hydrothermal conditions
(300, 350 and 400°C), in which 30% Ni-Ru/γ-Al2O3 serves as catalyst and
formic acid(FA) is used for in-situ H2 generation. The major products
were 1,2,3,4 tetrahydroquinoline, dehydroquinoline, aniline, methyl
aniline, 2-hexene, toluene. The quinoline conversion rate followed
first-order kinetics, and the activation energy was 41.72 kJ/mol. A
kinetic model based on the reaction network of hydrodenitrogenation of
quinoline clearly captures all of the trends in the data and fits the
temporal variation of all major products. Results reveal that
1,2,3,4-tetrahydroquinoline→dehydroquinoline→2-hexene is the main
quinoline HDN route. Reaction rate analysis illustrates deamination is
the main denitrogenation pathway. Sensitivity analysis demonstrated that
the production of aniline derivatives inhibits yield of quinoline
derivatives. TEM characterization indicates that nickel and ruthenium
metal are uniformly distributed on the supporter, which was confirmed by
XRD and XPS characterization as well.
Use of Impulse oscillometry for diagnostic of asthma in preschoolers: a cost-effectiveness analysis
Authors: Buendia Jefferson , Guerrer Diana
Published: January 2024

Background Impulse oscillometry is an alternative to measure lung
function in preschoolers because is much simpler and can be performed in
tidal breathing with minimal patient cooperation. The introduction of
new health technologies such as impulse oscillometry raises concerns as
if the extra benefit offered outweighs the additional cost compared to
spirometry This study aimed to evaluate the cost-effectiveness of
impulse oscillometry in preschoolers in Colombia. Methods We conducted a
decision tree model to estimate the cost and proportion of correctly
diagnosed cases of asthma of impulse oscillometry compared to spirometry
in preschooler’s children between 3-6 years old . The analysis was
carried out from a societal perspective. Multiple sensitivity analyses
were conducted. Cost-effectiveness was evaluated at a willingness-to-pay
value of $19,000. Results With impulse oscillometry, the proportion of
correctly diagnosed cases was 42%, while with spirometry was 39%. The
expected cost estimated by the model for a patient diagnosed with IOS
was U$ 174 while with spirometry was U$ 99. The incremental
cost-effectiveness ratio estimated in the probabilistic model was US$
6881. The one-way and probabilistic sensitivity analyses, our base‐case
results were robust to variations of all assumptions and parameters
Conclusion Impulse oscillometry was found to be cost-effective for the
diagnosis of asthma in preschoolers. Our results should stimulate
further research to expand the use of this diagnostic test in developing
countries.
KNOWLEDGE OF PERSONAL PROTECTIVE EQUIPMENT USE OF SENIOR PARAMEDIC STUDENTS BEFORE GRADUATION DURING COVID-19 PANDEMIC PERIOD
Authors: GULTEKIN TUĞBA , PAKDEMİRLİ Ahu , YENAL Sinan
Published: January 2024

Introduction: This study is planned to determine the knowledge of
personal protective equipment use of senior paramedic students before
graduation during COVID-19 pandemic. Methods: The research is a
descriptive study. The universe of the study consisted of 180 senior
paramedic students studying at three universities in İzmir. When
evaluating the study data, descriptive findings were expressed as
percentage, mean, standard deviation and median. Results: 38.1% of the
students are between 18-20 years old, 50.0% are between 21-23 years old
and 11.9% are 23 years old and above. 58.3% of the students
participating in the study are females and 41.7% are males. In the
study, 74.4% of paramedic students stated that healthcare personnel
working in ambulance or patient transport vehicles should use medical
masks, gowns, gloves and eye protection while transporting suspected
COVID-19- (SARS-CoV-2) patients to the health institution. 78.5% of the
students answered that an N95/FFP2 mask should be used while intervening
and taking samples in a patient suspected of having COVID-19.
Discussion: As a result, it was found that during the COVID-19 pandemic
period, the knowledge of personal protective equipment use of senior
paramedic students before graduation is sufficient in some cases and not
clear and sufficient in some cases. It is recommended that students
should be given effective training on the use of PPE during the
intervention of the patient with COVID-19 before graduation.
Preconceptional intake of folic acid supplementation and its associated factors: a cross sectional study on the Lebanese females of reproductive age
Authors: Ballout Batoul , Malaeb Diana , Cherri Sarah , malaeb Bassem , Diab Mariam Hajj
Published: January 2024

Objective: Infertility is recognized as a public health issue worldwide
where the total fertility rate is decreasing in most countries. Hence,
this study assesses the use of folic acid supplementation prior to
pregnancy in the Lebanese population. Method: It was a cross-sectional
study that took place between December 2019 and February 2020 using a
representative sample of community patients. Of 1000 participants who
were approached, 980 were completed and collected back. The sample was
drawn from the districts of all Lebanese governorates (Beirut, Mount
Lebanon, North Lebanon, South Lebanon, and Bekaa). Results: Conclusion:
The findings of this study about the assessment of the use of folic acid
prior to pregnancy may be the first step towards the development of
efficient health promotion programs oriented for the adequate
utilization of folic acid use among Lebanese population
Ethnic variation in causes of stillbirth in high income countries: A systematic review and meta-analysis
Authors: Bhat Saiuj , Birdus Nadya , Bhat Sangeeta
Published: January 2024

Background: Inequities in stillbirth rate according to ethnicity persist
in high income nations. Objectives: To investigate whether causes of
stillbirth differ by ethnicity in high-income nations. Search strategy:
Medline, Embase, Scopus, CINAHL, Cochrane Library, and Global Health
databases since their inception to 1 February 2021. Selection criteria:
Cohort, cross-sectional, and retrospective studies investigating the
causes of stillbirth in various ethnic groups. Data collection and
analysis: Systems of classification and causes of stillbirth were
aligned to the International Classification of Disease 10 for Perinatal
Mortality (ICD10-PM) and pooled estimates were derived by meta-analysis.
Main results: Fifteen reports from 3 countries (72,555 stillbirths) were
included. Seven ethnic groups – “Caucasian” (n = 11 studies, n =
37,578 stillbirths), “African” (n = 11 studies, n = 17,883
stillbirths), “Hispanic” (n = 7 studies, n = 12,810 stillbirths),
“Indigenous Australian” (n = 4 studies, n = 1,117 stillbirths),
“Asian” (n = 2 studies, n = 15 stillbirths), “South Asian” (n = 2
studies, n = 55 stillbirths), and “American Indian” (n = 1 study, n =
27 stillbirths) – were identified. There was an overall paucity of
recent, high-quality data for many ethnicities. For those with the
greatest amount of data – Caucasian, African, and Hispanic – no major
differences in the causes of stillbirth were identified. Conclusion:
There is a paucity of high-quality information on causes of stillbirth
for many ethnicities. Improving investigation and standardising
classification of stillbirths is needed to assess whether causes of
stillbirth differ across more diverse ethnic groups.
Therapeutic challenges of the modern era: QT prolongation management in COVID-19 hospitalised patients
Authors: Pollock Ailís , Kumar Rajesh , Devitt Patrick , Cheallaigh Clíona Ní , Kennedy Barry , Daly Caroline , Kent Brian
Published: January 2024

Introduction: Hydroxychloroquine, with or without Azithromycin, was used
as a treatment strategy for COVID-19 in March and April 2020. The use of
Hydroxychloroquine (HCQ), with or without Azithromycin, may increase the
risk of QT prolongation. This study was performed to assess the
incidence and degree of QT prolongation in hospitalised COVID-19
patients treated with HCQ, and the association with morbidity and
mortality. Methods and Results: Single centre retrospective
observational study. Baseline corrected QT interval (QTc), peak QTc and
change in QTc (∆QTc) were calculated for all patients. Known or
suspected risk factors for QT prolongation were assessed. All patients
were followed up for QT prolongation, length of stay, incidence of ICU
admission and 30 day all-cause mortality. Sixty-two patients were
included (mean age 67 years; 33.9% female). QT prolongation occurred in
62.9% of patients given HCQ, with ∆QTc ≥60msec or acquired QTc ≥500msec
in 14.5% of patients. The mean ∆QTc was 28.4msec. QT prolongation was
associated with increased mortality (OR 11.0; 95% CI 1.3 – 90.9;
P=0.03). Conclusions: There was a high incidence of QT prolongation in
patients who received HCQ as part of a COVID-19 treatment regimen. We
observed an increased risk of death in patients with QT prolongation, as
well as an increased incidence of ICU admission and longer length of
stay in hospital. We recommend particular attention be paid to the risk
of QT prolongation with novel treatment strategies for COVID-19. Further
research is warranted on the effect of QT prolongation on clinical
outcomes in COVID-19.
Experimental and theoretical investigation of continuous multistage countercurrent crystallizer
Authors: Xiao Wenlong , Yi Zhengming , Liu Yiming , Li Yonglin , Luo He'an
Published: January 2024

With the nitrochlorobenzene binary eutectic system and
naphthalene-benzathiophene solid solution system, the purification
process of tower crystallizer under continuous flow was investigated.
Under the optimal conditions, the p-nitrochlorobenzene and naphthalene
were purified to over 99.99%. Moreover, the theory of the purification
process is analyzed. Based on the fact that the rate of purification
flow at the cross section of the column was equal to the rate of removal
of impurities at the bottom of the column, a mathematical model of
continuous multistage countercurrent fractional crystallization process
was established. Comparing the calculated data with the experimental
data, the results demonstrate that the theoretical model can well
describe the mass concentration distribution in the tower crystallizer.
Appropriate reflux ratio and stirring are necessary to achieve an ideal
equilibrium state at a certain crystal bed height. It provides basis for
the industrial application of tower crystallizer.
Are Device Technology Personnel Valid or Valued Assets?
Authors: Tan Cian , Idhrees Mohammed , Bashir Mohamad
Published: January 2024

The involvement of Medical Technology (MedTech) corporations in the
provision of healthcare is in the spotlight following the introduction
of post-Brexit MedTech legislation in the UK. The relationship between
surgeons and device sales representatives is especially relevant in
cardiac surgery: the use of grafts, stents, prostheses, and other
devices is an integral component of most procedures. Many argue that the
involvement of device representatives in cardiac surgical cases is
valuable – they are often experts on their product, able to contribute
their expertise in challenging cases, and help ensure the procedure runs
smoothly. Yet, the potential for MedTech corporations to influence
surgeons’ clinical decision-making introduces a conflict-of-interest and
calls into question what the ‘best practice’ for sales reps should be.
The influence of MedTech corporations over policymaking bodies in the UK
also represents a major issue for transparency and is equally deserving
of evaluation.
Lymph node dissection in intermediate and high-intermediate risk endometrial cancer
Authors: akgör utku , salman coskun , Ozgul Nejat , Gultekin Murat
Published: January 2024

Introduction The aim of this study was to assess the impact of lymph
node dissection (LND) on survival for patients with intermediate risk
(IR) and high intermediate risk (HIR) endometrial cancer (EC). Methods
Clinicopathologic features and survival data of 1294 consecutive
patients who underwent primary surgical treatment for EC between 2003
and 2018 were were retrieved from the database of Hacettepe University
Hospital. This study compared the overall survival (OS) and disease-free
survival (DFS) among IR and HIR EC between patients with LND and no LND.
Results The study population included 141 (55 %) IR, and 115 (45 %)
HIR EC patients. LND was not performed in 33 (23.4%), and 31 (27%)
patients in IR, and HIR EC patients, respectively. The lymph node
involvement was 10.3% (n=20) among all patients. During the median
follow-up of 41 months (range, 12–222), 12 (6.2 %) patients with LND,
and 5 (7.8 %) patients without LND had disease recurrence (p=0.77). LND
did not improve OS and DFS in IR and HIR EC patients (p=0.92, p=0.80).
And the lymph node count was not associated with OS and DFS for all
subsets of patients with EC grouped by recurrence risks. Discussion
Without illuminating the morbidity of LND, there were no difference
observed in OS and DFS between IR and HIR EC patients with LND-induced
complications and no LND. With this regard, the use of sentinel lymph
node procedure might be better for minimizing the possible
post-operative morbidities in this selected patient groups.
Poly(I:C) and CpG Improve the Assembly of Foot-and-mouth Disease Virus-like Particles and Immune Response in Mice
Authors: Liu Haiyun , Teng Zhidong , Dong Hu , li jiajun , zhang yun , bai manyuan , Guo HuiChen , Sun Shiqi
Published: January 2024

Virus-like particles(VLPs) represent a safe and effective vaccine
platform, improving assembly efficiency is necessary to reduce the cost
of vaccine production, and elicit a strong immune response. In this
study, CpG and Poly(I:C) were selected as scaffolds to facilitate the
assembly of FMDV VLPs in vitro. The particle size, surface potential,
gel retardation assay, nuclease digestion experiments, size-exclusion
chromatography, transmission electron microscopy and circular dichroism
analysis showed that CpG and Poly(I:C) were successfully encapsulated
inside of VLPs, and have no effect on shape and sizes. The peak area of
75S of co-assembled CpG-VLPs and Poly(I:C)-VLPs were significantly
increased than FMDV-VLPs(P<0.0001). With increasing the
assembly efficiency of CpG-VLPs and Poly(I:C)-VLPs, higher neutralizing
antibodies were elicited. Although, CpG or Poly(I:C) as adjuvant
enhanced the proliferation level of spleen lymphocytes, but the
proportion of CD4+ T cells and CD8+ T cells in the lymphocyte were
significantly increased after stimulating by co-assembled CpG-VLPs
(P<0.01) and Poly(I:C)-VLPs (P<0.001). This study
demonstrated that CpG and Poly(I:C) not only improved the assembly
efficiency of FMDV VLPs, also had an adjuvant activity to enhance the
immune response, Furtherly, proposes a new idea and optimized strategy
for improving the assembly efficiency of VLPs and contributes to the
development of VLPs vaccine.
Evaluating the Association between Cardiac Memory T-wave and Cardiac Resynchronization Therapy Response in Patients with Heart Failure
Authors: Rad Mohammad Assadian , Emkanjoo Zahra , Moladoust Hassan , Vaezzadeh Hamed , Kheirkhah Jalal
Published: January 2024

Background and Aims: We evaluated whether cardiac memory T-wave (CMT) is
associated with reverse remodeling of left ventricular as an indicator
of response to cardiac resynchronization therapy (CRT). Methods and
Results: CMT was defined as a negative T-wave in right and mid
precordial leads with negative wide QRS complexes before CRT
implantation. We studied 100 patients (50 consecutive patients with CMT
and 50 consecutive patients without CMT) who underwent CRT. Patients’
resting 12-lead ECGs before and immediately after implantation of CRT
were analyzed by an electrophysiologist to confirm the presence or
absence of CMT. Response to CRT was defined as at least one NYHA class
decrease and ≥15% decrease in left ventricular end-systolic volume
(LVESV) 6 months after CRT implantation. Patients with and without CMT
were compared in terms of response to CRT. The number of patients with
CMT who responded to CRT was higher in comparison to the patients
without CMT (64% vs, 36%, p<0.001). In the multivariate
regression model, CMT remained associated with response to CRT after
adjusting for baseline characteristics [odds ratio (OR) (95% CI) 4.79
(2.01–11.43), P < 0.001]. Conclusion: There is a strong
relationship between the presence of CMT as a marker of reversed
ventricular remodeling and the response to CRT. Moreover, since CMT
occurs just after CRT implantation, it can be considered as an early
valuable predictor of response to CRT. Consequently, the presence of CMT
can be administered as a measure of response to CRT.
Oxygen Therapy Confers Little Benefit to Patients with Acute ST-Segment Elevation Myocardial Infarction: A Systematic Review and Meta-Analysis
Authors: Wang xinjuan , Li Cuiping
Published: January 2024

Abstract Objective: To investigate the clinical benefit of oxygen
therapy in patients with acute ST-segment elevation myocardial
infarction (STEMI). However, ST elevation myocardial infarction has not
been reported or controversial Methods: We searched PubMed, Embase, and
the Cochrane Library from database inception to June 2020 to identify
randomized controlled trials (RCTs) on oxygen therapy in acute STEMI.
Literature screening, data extraction, and study quality assessment were
independently carried out by two authors according to the predefined
eligibility criteria, and RevMan 5.3 analysis software was utilized for
all analyses. Results: Finally, 5 RCTs with 4,824 STEMI patients were
eligible for further meta-analysis. The results demonstrated that oxygen
therapy exerted non-significant effects in reducing the risks of
short-term all-cause mortality (RR = 1.21, 95% CI: 0.80 to 1.53, P =
0.53), cardiac arrest (RR = 1.20, 95% CI: 0.94 to 1.54, P = 0.79),
recurrent myocardial infarction (RR = 0.68, 95% CI: 0.43 to 1.08, P =
0.10), and cardiogenic shock (RR = 0.81, 95% CI: 0.58 to 1.15, P =
0.24) and the incidence of other outcome indicators of acute STEMI.
Conclusions: Oxygen therapy does not bring more benefits than adverse
effects on patients with acute STEMI. Personalized oxygen treatment
based on their dynamic oxygen saturation is recommended for hypoxic
patients. Key words: Acute ST-segment elevation myocardial infarction;
oxygen therapy; randomized controlled trial; meta-analysis
One-step Preparation of Epoxy Resin-based Ionic Gel Electrolyte for Solid-state Lithium Metal Batteries
Authors: Wang Zhennan , Shi Haobo , Zheng Weizhong , Sun Weizhen , ZHAO Ling , Yuan Wei-Kang
Published: January 2024

Solid state lithium metal batteries have attracted wide attention in
recent years due to their high energy density, flexibility, and high
safety. In this work, a novel epoxy resin-based ionic gel electrolyte
(IGE) was synthesized via one-step curing polymerization of epoxy
monomer and amine hardener with soft segments in the presence of ionic
liquid electrolytes. The morphology and molecular structure of IGE were
characterized by SEM, AFM and ATR-FTIR. The obtained IGEs showed high
room temperature ionic conductivity from 0.05 mS cm-1 to 1.69 mS cm-1.
In addition, the evolution of solid electrolyte interface (SEI) between
IGE and lithium metal was investigated by electrochemical impedance
spectroscopy, galvanostatic charge-discharge test and X-ray
photoelectron spectroscopy. Finally, The Li/IGE/LiFePO4 cells can
maintain a discharge capacity of 157 mAh g-1 at 0.1 C after 50 cycles at
60℃ and 132 mAh g-1 at 0.2 C after 150 cycles at room temperature.
A novel conceptual design of LNG-sourced natural gas peak-shaving with gas hydrates as the medium
Authors: Chen Chen , Haoyu Yuan , Bi Rong , He Yan , Wang Fei
Published: January 2024

Efficient peak-shaving technology is critical to couple with the
ever-increasing natural gas demand, especially in the regions lack of
natural gas resources. The aim of this paper is to present a novel
natural gas peak-shaving process with gas hydrates as the medium to
address the issue of natural gas supply and demand imbalance, especially
for the LNG-sourced natural gas, in which the cold energy from LGN
gasification can be efficiently utilized. Firstly, the whole process,
including the production, storage, and dissociation of NGH is designed;
afterwards, energy consumption analysis and economic accounting are
conducted; finally, a case study is carried out to show the efficiency
of the technology. The results show that the economic effectiveness can
be improved maximumly by 9.42% compared to the traditional operation
model of LNG receiving terminal, indicating the feasibility of providing
a flexible natural gas peak-shaving process with the gas hydrate as
medium.
Global Greenhouse Gases Emissions Effect on Extreme Events under an Uncertain Future: a case study in Western Cape, South Africa
Authors: He Bowen , Ding Ke
Published: January 2024

The growing effect of CO2 and other greenhouse-gas (GHG) emissions on
the extreme climate risks in the Western Cape, South Africa, calls for
the need for better climate adaptation and emissions-reduction
strategies to protect region’s long-term social-economic benefits. This
paper presents a comprehensive evaluation of changes in the future
extreme events associated with drought and heatwave under three
different greenhouse gases (GHG) emissions scenarios: Representative
Concentration Pathway (RCP) 2.6, RCP 4.5, and RCP 8.5, from moderate to
severe, respectively. A variety of diagnostic indices are used to
determine how future heatwaves and drought will response to each
different RCP climate scenario in Western Cape based on Max Planck
Institute-Earth System Model/REMO (MPI-ESM/REMO). The projected
simulation results reveal that both drought-related and heatwave-related
extreme climate indices suggest very strong relationships between the
future extreme climate risks and the GHG emissions for Western Cape,
South Africa. Anthropogenic activities and growing GHG emissions will
lead to severer extreme climate stress in terms of drought as well as
duration, frequency, and magnitude of heatwave stresses. As a result, we
believe that reducing the GHG emissions to alleviate future extreme
climate stress becomes a practical solution to protect the local’s
socio-economic system and further maintain the region’s economic
prosperity.
Isolated Long-Term Anticoagulation as an Alternative for the Management of Bioprosthetic Mitral Valve Thrombosis in a High-Risk Surgical Patient
Authors: Kassab Joseph , Azar Rabih
Published: January 2024

We herein describe a case and provide images of a bioprosthetic mitral
valve thrombosis and a huge left atrial appendage thrombus occurring
during atrial fibrillation 12 years after initial heart surgery. The
patient was treated conservatively with oral anti-coagulation because he
was a high surgical risk with complete resolution of the thrombosis
after 2 months of therapy. This case suggests that in a high surgical
risk patient, effective oral anticoagulation might be a good alternative
to surgery.
Children with allergic asthma sensitized to house dust mites getting better health during COVID-19 pandemic
Authors: Li Yuyun , Zhi Lili , Zhu Yunmei , Qiao Lan , Zhu Yan , Hu Xin , Wang Qian , Wang Dongming , Bi Fangjie
Published: January 2024

Background: Since December 2019, 2019 novel corona virus (2019-nCov)
disease (COVID-19) has extended to most parts of China with more than 80
thousand cases. From Feb 1 to Mar 31
of 2020, all children were asked to stay indoors in
China. Then how it affected allergic asthma (AA) sensitized to house
dust mites (HDM) in children was interestingly to clarify. Objective: To
investigate the changes of clinical characteristics of children with AA
sensitized to HDM during COVID-19 pandemic. Method: The data including
asthma symptom scores(SS), visual analog scores (VAS), asthma quality of
life questionnaire (AQLQ) and medicine scores (MS) as well as
respiratory infections, cares, staying up late and diets, collected from
children with AA sensitized to HDM from Feb 1 to
Mar 31 of 2019 and 2020 retrospectively, were
analyzed. Results: There were 85 children with AA sensitized to HDM
included in this research. Compared with SS, VAS, AQLQ and MS of the
patients from Feb 1 to Mar 31
of 2019, SS, VAS, AQLQ and MS of the patients improved significantly
(p<0.05) during COVID-19 pandemic. No respiratory infections
occurred among them and they got better cares, had better diets and
stayed up late less during COVID-19 pandemic. Conclusion: During
COVID-19 pandemic, children with AA sensitized to HDM got better health
for staying indoors, which might be associated with no respiratory
infections, better cares, better diets and less staying up late.
External cephalic version: success rates with and without nitrous oxide
Authors: Ha Thoa , Lamar Robyn , Blat Cinthia , Rosenstein Melissa
Published: January 2024

Objective To compare the conversion rate of non-cephalic to cephalic
presentation in external cephalic version (ECV) with and without nitrous
oxide Design Retrospective cohort study Setting Single, tertiary care
institution between January 2016 an June 2017 Population Women with
singleton, term gestation ECVs identified via International
Classification of Diseases Clinical Modification diagnosis code with
breech or malpresentation. Pregnancies with preterm, multi-fetal
gestation, abnormal placentation, and rupture of membranes were excluded
Methods Logistic regression was performed to test whether nitrous oxide
was associated with successful conversion to cephalic presentation. Main
Outcomes The primary outcome was successful rate of conversion to
cephalic presentation. The secondary outcome was the rate of vaginal
delivery. Results During the study period, 167 women underwent ECV: 77
with nitrous oxide and 90 without nitrous oxide. Of the 77 women who
used nitrous oxide, 25 (32.5%) were successful and 17 of these women
delivered vaginally (68%). Of the women who underwent ECV without
nitrous oxide, 29 (32.2%) successfully converted and 21 of these
delivered vaginally (72%). After controlling for confounders, the use
of nitrous oxide had no clinically or statistically significant
difference on ECV success rates (OR 1.08, 95% CI 0.52-2.23). Conclusion
Nitrous oxide does not seem to affect conversion rate to cephalic
presentation in ECV. Further studies are needed to determine the impact
of nitrous oxide on women’s decision to undergo ECV and on patient
satisfaction and tolerability. Funding The authors received no financial
support for the research, authorship, or publication of this data.
CRUCIAL ROLE OF PLACENTA - REVIEW
Authors: S Sangeetha
Published: January 2024

The placenta is a large organ that develops during pregnancy that
attaches to the wall of your uterus, and the baby’s umbilical cord
arises from it. The umbilical cord connects the placenta to the baby.
Blood from the mother passes through the placenta, filtering oxygen,
glucose and other nutrients to your baby via the umbilical cord. The
placenta also filters out substances that could be harmful to the baby
and removes carbon dioxide and waste products from the baby’s blood. KEY
WORDS: Placenta, pregnancy, blood, umbilical cord.
Manifestations and outcomes of intracerebral hemorrhage during COVID‐19 pandemic in China: a multicenter, longitudinal cohort study
Authors: He Quanwei , Wan Yan , Chen Shaoli , Li Man , Xia Yuanpeng , Zhang Lei , Sun Zhou , Chen Xiaolu , Wang David , Zhao Xingquan , Wang Yongjun , Hu Bo
Published: January 2024

Background: We just right were carrying out a multicenter
cohort study about ICH when COVID-19 broke out in Wuhan，and we wondered
whether COVID-19 pandemic was associated with the manifestations and
outcomes of intracerebral hemorrhage (ICH). Methods: Acute ICH
patients before (1/12/2018-30/11/2019) and during
COVID-19(1/12/2019-30/11/2020) pandemic at 31 centers in China, were
entered into the analysis. Demographic information, clinical
manifestations and outcomes were collected and compared between the two
groups. Results: From December 1, 2018 to November 30, 2020, a
total of 3460 patients with ICH were enrolled and eventually analyzed.
Results showed that patients with ICH were more likely to be older, have
higher systolic blood pressure (BP) (P<0.001), diastolic-BP
(P=0.002), higher admission NIHSS score (P=0.039) and higher fasting
blood glucose (P=0.003) during COVID-19 pandemic compared with before.
After adjusting age, gender, COVID-19 pandemic was associated with
3-month poor outcome (OR = 1.206, 95%CI:
1.043-1.395) and 3-month mortality (OR = 1.711,
95%CI: 1.428-2.050) after ICH onset. Conclusions: COVID-19
pandemic deteriorated the manifestations and outcomes of ICH.
A Review on Seaweed Farming in Western Indian Ocean: Benefits and Challenges
Authors: RIPANDA ASHA SHABANI , Mtenga Deodata
Published: January 2024

Seaweed farming in the Western Indian Ocean (WIO) is among the
income-generating activities; apart from seaweeds being primary
producers, they are foundation species important for marine ecosystem
capable of modifying their surrounding abiotic and biotic environments.
The WIO coast provides natural and necessary environments for seaweeds
farming. In this review article seaweed farming in WIO was investigated;
its contribution to provision of ecosystem services; medicinal and
nutritional value; role of women; challenges and the wellbeing of
farmers and the whole ecosystem. It was observed that among the
challenges facing seaweed farmers include lack of modernized farming
tools hence farmers use low depth areas leading to attack by diseases,
death of seaweed, low yields, and income. Farmers has been reported to
be affected by diseases which may be contributed by inadequate of use of
protective gears, indicating the need for knowledge on personal
protection. This may be contributed by lack of knowledge which leads to
farmers participation without using protective equipment leading to
contamination from toxic chemical compounds from seaweed, epiphytic
bacteria or harmful algal bloom and absorbed heavy metals from seawater
as a result of long-term exposure. Farming practices such as uprooting
of seaweeds during farm preparation have been observed to cause
degradation and decrease fish population. Therefore, there is the need
for use of modern technologies; supervision of these activities by
professionals in the field, and provision of knowledge to farmers for
the sustainability of WIO marine ecosystem.
Exotic hybrid rogue wave and breather solutions for a complex mKdV equation in shallow water wave and optics
Authors: Li Bang-Qing , Ma Yu-Lan
Published: January 2024

We report exotic hybrid rogue wave and breather solutions for a complex
mKdV equation describing soliton dynamics in shallow water wave and
optics. Starting from the Lax pair, the higher-order Darboux
transformations for the equation are constructed. Further, we obtain a
series of theorems to compute the hybrid rogue wave and breather
solutions. We also demonstrate the interaction features between rogue
waves and breathers by controlling parameters. These results are of
importance to understand nonlinear wave dynamics in water wave systems.
Serious Proptosis due to Myeloid Sarcoma, Dramatic Recovery with Chemotherapy: a Case Report
Authors: Karagenç Ayşe Özkan , Arslantaş Esra , Solğun Huseyin Avni , Aycicek Ali
Published: January 2024

Myeloid sarcoma (MS) occurs when immature myeloid cells settle in the
extra medullary area. It may be associated with acute myeloblastic
leukemia (AML) or it may be alone and then develop AML. The orbit is one
of the places where myeloid sarcoma is common in childhood. In this case
report, we present a case of orbital myeloid sarcoma living in Africa,
presenting with advanced proptosis and vision loss, whose proptosis
improved dramatically with chemotherapy and vision returned.
The origin and molecular characterization of the BEF virus caused by the small-scale epidemic in Western Turkey
Authors: PEKMEZ Kemal , KAPLAN Murat , ÇAĞIRGAN Abdurrahman Anıl , ARSLAN Fatih
Published: January 2024

Bovine ephemeral fever (BEF), also known as three-day fever and
three-day disease, is an arthropod-borne viral disease of the buffalo
and domestic cattle. Bovine ephemeral fever virus (BEFV) is the
causative agent of the disease. In this study, we tried to detect the
molecular characterization and possible source of BEF virus that caused
an epidemic within a limited area synchronously and in two separate
localizations in the Aegean region in November, 2020. As a result, BEF
virus was declared in Aegean region for the first time, G gene
characterization was performed, the virus was classified within the
Middle East lineage, and animal movements were believed to have been
effective for the virus to reach the area.
Is COVID-19 infection triggering oral herpes zoster? A case report
Authors: Saleh Wafaa , Ata Fatma , Elashry Mohamed M
Published: January 2024

Abstract Humans infected with COVID-19 are at risk of developing
life-threatening conditions. We here present a case of rapid appearance
of oral lesion of herpes zoster associated with COVID-19 infection. Our
case highlights the importance of oral examination as well as oral care
in patients with COVID-19.
Anthropogenic and climate constraints on diversity and structure of terrestrial vertebrate communities
Authors: Penjor Ugyen , Cushman Samuel , Kaszta Zaneta , Sherub Sherub , Macdonald David
Published: January 2024

Land use and climate change interact to impact functional and
phylogenetic diversity globally, but this pattern is largely unknown in
Eastern Himalayas. Using data comprising 45 mammal species and 336 bird
species, we investigated the response of taxonomic, functional, and
phylogenetic diversity and structure to land use and climate variables
in the Himalayan biodiversity hotspot of Bhutan. Community diversity and
structure in both groups were lower than expected by chance and
decreased with land-use change resulting in clustering of distinct
assemblages in different land-use settings, but climate produced mixed
results. Functional and phylogenetic overdispersion for mammals were
best explained by precipitation while temperature did so in birds.
Overall, the mammal community better tolerated extreme climates than did
birds. However, the nuances in individual responses were variable across
the phylogenetic tree. Our results highlight the importance of land use
and climate gradients in shaping the regional terrestrial biodiversity
in a fragile and dynamic conservation landscape.
Certain weighted fractional integral inequalities for convex functions
Authors: Yıldız Çetin , Gürbüz Mustafa
Published: January 2024

In this study, by using the monotonicity properties of functions,
several inequalities for convex functions are obtained with the help of
a fractional integral operator which provides a function to be
integrated in fractional order with respect to another function. It is
also seen that the results obtained were generalizations of the previous
results presented.
Abdominal Pregnancy at 38 weeks with good maternal and perinatal outcome: A Review Article
Authors: Chaudhary Anjali , Varma Umesh , Gupta Nishchal , Jaiswal Shubhra , Varma Aditya
Published: January 2024

Abdominal Pregnancy at 38 weeks with good maternal and perinatal
outcome: A Review Article An advanced abdominal pregnancy with a good
fetal and maternal outcome is extraordinary occurrence because it is
rare, associated with high morbidity and mortality for both fetus and
mother. We present a case of abdominal pregnancy which was an emergency
diagnosis on OT table while performing elective LSCS for 38 weeks with
breech with previous LSCS with normal documented prenatal sonographies.
Post delivery of baby by breech extraction, the torrential bleed and
massive hemorrhage from placenta adhering to bowel and omentum was a big
challenge.
Congenital Atresia of the Left Main coronary artery: new presentation in a septuagenarian
Authors: Cyclewala Shabnam , Khan Taimoor , Salmasi Mohammad , Bahrami Toufan
Published: January 2024

Congenital anomalous anatomy and course of coronary arteries are common
however atresia of LMS is extremely a rare condition. Fewer than 50
cases of congenital atresia of left main stem coronary artery have been
reported in the literature. The ostium or trunk of the left coronary
artery is atretic, and the left coronary artery and its branches are
supplied by the right coronary artery via coronary collaterals in a
retrograde direction. The pattern of presentation varies depending on
the age and anatomy of the patient. According to the literature these
cases present at a very early age with signs of heart failure whereas
adults may present with angina or shortness of breath. Its clinical
signs and symptoms often resemble anomalous origin of the left coronary
artery from the pulmonary artery and endomyocardial fibrosis. In
literature there are only five adult cases reported with congenital
atresia of LMS and an interesting fact is that one out of those five
cases was diagnosed on autopsy to have atresia of LMS. That patient was
a female at age of 76 years who died of reasons other than heart
symptoms. Therefore it may be inferred that the range of symptoms vary
from being completely asymptomatic to overt heart failure.
Tuberculous myelitis as an unusual presentation of a common disease in Sudan
Authors: Ibrahim Eetadal , Mohammed Khalid Mohammed , Mustafa Lina Hussain , Ahmed Khabab Mohamed , Omer Mohammed
Published: January 2024

Tuberculosis(TB) is a common disease in Sudan .Neurological consequences
of TB are frequently encountered in our practice of neurology
particularly tuberculosis of the spine(Pott,s disease).There are few
case reports of tuberculous myelitis in literature.
Pathomimia: Self-inflicted ulcerations of the hand, ankles and more
Authors: Bouabdella Sara , Saddouk Hasnae , Ouadi Imane , Zizi Nada , Dikhaye Siham
Published: January 2024

Pathomimia is manifested by self-induced skin lesions. It is difficult
to diagnose and a challenge to treat.We report the case of a young male
patient with unknown psychiatric history and self-induced skin lesions
of hands and ankles.
B cell acute lymphoblastic leukemia following mild COVID-19 in an 11-year-old boy
Authors: Chen Hui , Xu Qian , Liu Yi , Gong Wenyu , Li Jun , Liang Jing , Zhang Xue , Wu Runhui , Chen Zhenping
Published: January 2024

Coronavirus disease-2019 (COVID-19) has infected millions of people with
high lethality in the world, but little is known whether severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has impacts on
triggering pediatric acute lymphoblastic leukemia (ALL). We present a
case of a child with atypical clinical manifestation who developed
B-cell acute lymphoblastic leukemia following a mild symptomatic
COVID-19 infection. This case underlines the risks of potential
oncogenic effects with the history of this viral infection and a state
of immunosuppression.