bluuebunny/crossref_metadata_2025 huggingface dataset:
Pinning Synchronization of Nonlinearly Coupled Complex Dynamical Networks on Time Scales
Authors: Kong Fang-Di
Published: July 2020

In this paper, we study the synchronization problem for nonlinearly coupled complex dynamical networks on time scales. To achieve synchronization for nonlinearly coupled complex dynamical networks on time scales, a pinning control strategy is designed. Some pinning synchronization criteria are established for nonlinearly coupled complex dynamical networks on time scales, which guarantee the whole network can be pinned to some desired state. The model investigated in this paper generalizes the continuous-time and discrete-time nonlinearly coupled complex dynamical networks to a unique and general framework. Moreover, two numerical examples are given for illustration and verification of the obtained results.
Research on an Improved Metal Surface Defect Detection Sensor Based on a 3D RFID Tag Antenna
Authors: Li Qiang , Chen Jianbin , Zhao Liang
Published: July 2020

Structural health monitoring (SHM) technology is a monitoring process and early warning method for the health status or damage of special workpiece structures by deploying sensors. In recent years, there have been many studies on SHM, such as ultrasonic, pulsed eddy current, optical fiber, magnetic powder, and other nondestructive testing technologies. Due to their sensor deployment, testing environment, power supply, and transmission line wiring mechanism, they bring problems such as detection efficiency, long-term monitoring, and unreliable systems. The combination of wireless sensing technology and intelligent detection technology is used to solve the above problems. Therefore, this paper studies the tag antenna smart sensor, which is used to characterize the extension of metal defects in SHM. Then, it presents a wireless passive three-dimensional sensing antenna, and simulations verify the feasibility of the antenna. The simulation results show that the antenna can characterize the two extension directions of depth and width of the metal surface structure smooth defect. At the same time, the antenna can characterize the position of smooth defects on the surface of metal structures relative to the antenna and then realize the smooth defect positioning.
Bénard Problem for Slightly Compressible Fluids: Existence and Nonlinear Stability in 3D
Authors: Passerini Arianna
Published: July 2020

This paper shows the existence, uniqueness, and asymptotic behavior in time of regular solutions (a la Ladyzhenskaya) to the Bénard problem for a heat-conducting fluid model generalizing the classical Oberbeck–Boussinesq one. The novelty of this model, introduced by Corli and Passerini, 2019, and Passerini and Ruggeri, 2014, consists in allowing the density of the fluid to also depend on the pressure field, which, as shown by Passerini and Ruggeri, 2014, is a necessary request from a thermodynamic viewpoint when dealing with convective problems. This property adds to the problem a rather interesting mathematical challenge that is not encountered in the classical model, thus requiring a new approach for its resolution.
MEST Regulates the Stemness of Human Periodontal Ligament Stem Cells
Authors: Hasegawa Daigaku , Hasegawa Kana , Kaneko Hiroshi , Yoshida Shinichiro , Mitarai Hiromi , Arima Mai , Tomokiyo Atsushi , Hamano Sayuri , Sugii Hideki , Wada Naohisa , Kiyoshima Tamotsu , Maeda Hidefumi
Published: July 2020

Periodontal ligament (PDL) stem cells (PDLSCs) have been reported as a useful cell source for periodontal tissue regeneration. However, one of the issues is the difficulty of obtaining a sufficient number of PDLSCs for clinical application because very few PDLSCs can be isolated from PDL tissue of donors. Therefore, we aimed to identify a specific factor that converts human PDL cells into stem-like cells. In this study, microarray analysis comparing the gene profiles of human PDLSC lines (2-14 and 2-23) with those of a cell line with a low differentiation potential (2-52) identified the imprinted gene mesoderm-specific transcript (MEST). MEST was expressed in the cytoplasm of 2-23 cells. Knockdown of MEST by siRNA in 2-23 cells inhibited the expression of stem cell markers, such as CD105, CD146, p75NTR, N-cadherin, and NANOG; the proliferative potential; and multidifferentiation capacity for osteoblasts, adipocytes, and chondrocytes. On the other hand, overexpression of MEST in 2-52 cells enhanced the expression of stem cell markers and PDL-related markers and the multidifferentiation capacity. In addition, MEST-overexpressing 2-52 cells exhibited a change in morphology from a spindle shape to a stem cell-like round shape that was similar to 2-14 and 2-23 cell morphologies. These results suggest that MEST plays a critical role in the maintenance of stemness in PDLSCs and converts PDL cells into PDLSC-like cells. Therefore, this study indicates that MEST may be a therapeutic factor for periodontal tissue regeneration by inducing PDLSCs.
Mutant FOXL2C134W Hijacks SMAD4 and SMAD2/3 to Drive Adult Granulosa Cell Tumors
Authors: Weis-Banke Stine E. , Lerdrup Mads , Kleine-Kohlbrecher Daniela , Mohammad Faizaan , Sidoli Simone , Jensen Ole N. , Yanase Toshihiko , Nakamura Tomoko , Iwase Akira , Stylianou Anthe , Abu-Rustum Nadeem R. , Aghajanian Carol , Soslow Robert , Da Cruz Paula Arnaud , Koche Richard P. , Weigelt Britta , Christensen Jesper , Helin Kristian , Cloos Paul A.C.
Published: July 2020

The mutant protein FOXL2C134W is expressed in at least 95% of adult-type ovarian granulosa cell tumors (AGCT) and is considered to be a driver of oncogenesis in this disease. However, the molecular mechanism by which FOXL2C134W contributes to tumorigenesis is not known. Here, we show that mutant FOXL2C134W acquires the ability to bind SMAD4, forming a FOXL2C134W/SMAD4/SMAD2/3 complex that binds a novel hybrid DNA motif AGHCAHAA, unique to the FOXL2C134W mutant. This binding induced an enhancer-like chromatin state, leading to transcription of nearby genes, many of which are characteristic of epithelial-to-mesenchymal transition. FOXL2C134W also bound hybrid loci in primary AGCT. Ablation of SMAD4 or SMAD2/3 resulted in strong reduction of FOXL2C134W binding at hybrid sites and decreased expression of associated genes. Accordingly, inhibition of TGFβ mitigated the transcriptional effect of FOXL2C134W. Our results provide mechanistic insight into AGCT pathogenesis, identifying FOXL2C134W and its interaction with SMAD4 as potential therapeutic targets to this condition.

Significance:

FOXL2C134W hijacks SMAD4 and leads to the expression of genes involved in EMT, stemness, and oncogenesis in AGCT, making FOXL2C134W and the TGFβ pathway therapeutic targets in this condition.
Lightning-Storm Periungual Capillaries in a Patient with Complex Regional Pain Syndrome Type I
Authors: Perez Mariana , Vazquez Thomas , Canazza Agnese , Zaiac Martin
Published: July 2020

Introduction: Complex regional pain syndrome (CRPS) is characterized by chronic pain out of proportion to injury following trauma. CRPS most commonly results after crush-type injury to the hand and may be associated with various cutaneous symptoms believed to be driven by vasomotor instability. Existing reports in the literature have employed a range of methodologies to describe and evaluate cutaneous and vascular changes in CRPS, though there exists no current gold standard for diagnosis. Case Presentation: Here, we report a 71-year-old male with a 10-year history of CRPS who presented with abnormal capillaries on onychoscopy, demonstrating a “lightning-storm” pattern. Conclusion: Previous studies have shown increased blood flow to the cutis in the early stage of CRPS, yet diminished cutaneous flow during the later stages. However, one study showed increased nail capillary diameter in patients with later stage CRPS. Due to a variety of reported clinical characteristics and a nonspecific clinic presentation, both the recognition and diagnosis of CRPS is difficult. Nail fold capillaroscopy may be a useful and accessible tool for evaluating patients with CRPS.
Tattoo-Associated Basal Cell Carcinoma: Coincident or Coincidence
Authors: Cohen Philip R. , Erickson Christof P. , Uebelhoer Nathan S. , Calame Antoanella
Published: July 2020

Tattoos may be associated with medical complications including, albeit rarely, skin cancer. The features of a 46-year-old man who developed a basal cell carcinoma within a tattoo on his left scapula are described and the characteristics of the other 13 patients (7 men and 6 women) with tattoo-associated basal cell carcinoma are reviewed. The tumor usually occurs on the sun-exposed skin of individuals aged 60 years and older whose tattoo has often been present for 20 years or more. The pathogenesis of a basal cell carcinoma developing within a tattoo may merely be a coincidence. However, there is supporting evidence that the tattoo and the subsequent basal cell carcinoma may be coincident events whereby either tattoo injection-associated trauma or the tattoo pigments and dyes (in their native state or after ultraviolet radiation alteration) or both have a carcinogenic impact on the development of the basal cell carcinoma at that location.
Feasibility of Citrate Dialysis in Hyponatremia: A Case Series
Authors: Redant Sebastien , De Bels David , Massaut Jacques , Barglazan Dragos , Lebitasy Precieux M. , Honoré Patrick M.
Published: July 2020

Background: Correcting hyponatremia too quickly can lead to osmotic demyelination syndrome. During citrate dialysis, a significant sodium load is brought to the prefilter. We reviewed the impact of this sodium load on the evolution of sodium levels in patients undergoing continuous renal replacement therapy with citrate anticoagulation. Materials and Methods: The medical records of 5 patients with hyponatremia who received dialysis with citrate anticoagulation, over a 10-year period, were reviewed. The sodium of the dialysate and of the reinjection fluid was adapted according to the serum sodium level recommended by the guidelines of the time. Data from the first 24 h after initiation of dialysis was evaluated. Results: The difference in serum sodium levels between day 1 and day 2 was statistically significant, with a rise of 7.8 ± 3.7 mmol/L. Discussion: The mean serum sodium increase in our series of patients did not exceed the increase of 10–12 mEq/L/day permitted by the guidelines. The excess sodium was absorbed by the filter. Conclusion: In this small series of patients, with adjustment of the sodium concentration of dialysate and reinjection fluid, the use of citrate was found to be safe.
Transcatheter Aortic Valve Implantation Represents an Anti-Inflammatory Therapy Via Reduction of Shear Stress–Induced, Piezo-1–Mediated Monocyte Activation
Authors: Baratchi Sara , Zaldivia Maria T.K. , Wallert Maria , Loseff-Silver Julia , Al-Aryahi Sefaa , Zamani Jalal , Thurgood Peter , Salim Agus , Htun Nay M. , Stub Dion , Vahidi Parisa , Duffy Stephen J. , Walton Antony , Nguyen Thanh Ha , Jaworowski Anthony , Khoshmanesh Khashayar , Peter Karlheinz
Published: July 2020

Background:

Aortic valve stenosis is an increasingly prevalent degenerative and inflammatory disease. Transcatheter aortic valve implantation (TAVI) has revolutionized its treatment, thereby avoiding its life-threatening/disabling consequences. Whether aortic valve stenosis is accelerated by inflammation and whether it is itself a cause of inflammation are unclear. We hypothesized that the large shear forces exerted on circulating cells, particularly on the largest circulating cells, monocytes, while passing through stenotic aortic valves result in proinflammatory effects that are resolved with TAVI.

Methods:

TAVI provides a unique opportunity to compare the activation status of monocytes under high shear stress (before TAVI) and under low shear stress (after TAVI). The activation status of monocytes was determined with a single-chain antibody, MAN-1, which is specific for the activated β
2
-integrin Mac-1. Monocyte function was further characterized by the adhesion of myocytes to stimulated endothelial cells, phagocytic activity, uptake of oxidized low-density lipoprotein, and cytokine expression. In addition, we designed a microfluidic system to recapitulate the shear rate conditions before and after TAVI. We used this tool in combination with functional assays, Ca
2+
imaging, siRNA gene silencing, and pharmacological agonists and antagonists to identify the key mechanoreceptor mediating the shear stress sensitivity of monocytes. Last, we stained for monocytes in explanted stenotic aortic human valves.

Results:

The resolution of high shear stress through TAVI reduces Mac-1 activation, cellular adhesion, phagocytosis, oxidized low-density lipoprotein uptake, and expression of inflammatory markers in monocytes and plasma. Using microfluidics and pharmacological and genetic studies, we could recapitulate high shear stress effects on isolated human monocytes under highly controlled conditions, showing that shear stress–dependent calcium influx and monocyte adhesion are mediated by the mechanosensitive ion channel Piezo-1. We also demonstrate that the expression of this receptor is shear stress dependent and downregulated in patients receiving TAVI. Last, we show monocyte accumulation at the aortic side of leaflets of explanted aortic valves.

Conclusions:

We demonstrate that high shear stress, as present in patients with aortic valve stenosis, activates multiple monocyte functions, and we identify Piezo-1 as the mainly responsible mechanoreceptor, representing a potentially druggable target. We demonstrate an anti-inflammatory effect and therefore a novel therapeutic benefit of TAVI.
Thiazide Use and Decreased Risk of Heart Failure in Nondiabetic Patients Receiving Intensive Blood Pressure Treatment
Authors: Tsujimoto Tetsuro , Kajio Hiroshi
Published: July 2020

The SPRINT (Systolic Blood Pressure Intervention Trial) study reported that intensive blood pressure (BP) treatment with a systolic BP target of <120 mm Hg decreased the risks of cardiovascular events. However, it remains unknown whether specific medications can further improve cardiovascular outcome in patients receiving intensive BP treatment. This study examined whether thiazide use improves cardiovascular outcome in patients receiving intensive BP treatment. We used data of nondiabetic patients receiving intensive BP treatment in the SPRINT study. The primary outcome was a composite end point of myocardial infarction, acute coronary syndrome, stroke, heart failure, or cardiovascular death. We analyzed hazard ratios for outcomes with 95% CIs in patients taking thiazides compared with those not taking thiazides using Cox proportional hazard models. This study included 2847 patients and the mean follow-up period was 3.3 years. The risk of primary outcome events was significantly lower in patients taking thiazides than in those not taking thiazides in both entire and propensity score-matched cohorts. Particularly, heart failure risk was significantly lower in those taking thiazides. These associations were also observed in various subgroups. In addition, thiazide use was associated with decreased risk of all-cause mortality. Hypokalemia occurred more frequently in patients taking thiazides than in those not taking thiazides. Thiazide use decreased risk of cardiovascular events, particularly heart failure, in nondiabetic high-risk patients receiving intensive BP treatment.
Myrcia guedesiae (Myrtaceae), a new species from the Atlantic Forest of Bahia, Brazil

Authors: MELO JANINE DIAS DE OLIVEIRA , STADNIK ALINE , ROQUE NÁDIA
Published: July 2020

Myrcia guedesiae, a new species from the Atlantic Forest of South of Bahia State, is described and illustrated. Morphologically, the new species belongs to Myrcia sect. Aulomyrcia and is apparently related to M. hirtiflora and M. racemosa, differing in its leaves, inflorescences branches, number of flowers, hypanthium and calyx lobes on fruits.
Three new species of the genus Ammatho Walker, 1855 from China and Indochina (Lepidoptera: Erebidae: Arctiinae: Lithosiini)
Authors: HUANG SI-YAO , VOLYNKIN ANTON V. , WANG MIN , FAN XIAO-LING
Published: July 2020

Three new species of the genus Ammatho Walker, 1855 are described from mainland China and Indochina: Ammatho (Striatella) inexpecta Huang & Volynkin sp. nov. from Guangdong, Southern China and Tam Dao, Northern Vietnam; Ammatho (Ammathella) gesar Huang & Volynkin sp. nov. from Xizang, Southwestern China and Ammatho (Ammathella) shingwa Volynkin & Huang sp. nov. from Kachin, Northeastern Myanmar. Adults and genitalia of related species are illustrated.
Qualitative and Semiquantitative Determination of the Atomic and Molecular Tungsten Distributions in Hybrid Hydroxyurethanes–Poly(dimethylsiloxane) Films Containing Phosphotungstates ([PW12O40]3–)
Authors: Ysnaga Orlando Elguera , de Aguiar Kelen M.F. Rossi , Zamboni Cibele Bugno , Polito Wagner Luiz , Rodrigues-Filho Ubirajara P.
Published: July 2020

In this study, hybrid poly(dimethylsiloxane)-derived hydroxyurethanes films (PDMSUr-PWA) containing phosphotungstic acid (H3PW12O40/PWA) were characterized using field emission gun scanning electron microscopy (FEG-SEM), in attenuated total reflectance Fourier transform mid-infrared mode (ATR FT-MIR), and analyzed using synchrotron radiation micro-X-ray fluorescence (SR-μXRF), synchrotron radiation grazing incidence X-ray fluorescence (SR-GIXRF), laser-induced breakdown spectroscopy (LIBS), and instrumental neutron activation analysis (NAA) in order to correlate the distribution patterns of tungsten and properties of PDMSUr-PWA films. PDMS constitute elastomers with good mechanical, thermal, and chemical (hydrophobicity/non-hygroscopy) resistance. Currently, products based on urethanes (e.g., polyurethanes) are widely used in many applications as plastics, fiber-reinforced polymers, high-performance adhesives, corrosion-resistant coatings, photochromic films, among others. The possibility to combine inorganic and organic components can produce a hybrid material with unique properties. PWA has an important role as agent against the corrosion of steel surfaces in different media, besides exhibiting amazing catalytic and photochromic properties in these films. PWA kept its structure inside of these hybrid films through interactions between the organic matrix of PDMSUr and silanol from the inorganic part (organically modified silica), as was shown using ATR FT-MIR spectra. The FEG-SEM/SR-μXRF/wide-angle X-ray scattering (WAXS)/X-ray diffraction (XRD)/energy dispersive X-ray results proved the presence of PWA in the composition of domains of PDMSUr-PWA films. At PWA concentrations higher than 50 wt%/wt, tungsten segregation across the thickness is predominant, while that at PWA concentrations lower than 35 wt%/wt, tungsten segregation at surface is predominant. Inhomogeneities in the tungsten distribution patterns (at micrometric and millimetric level) may play an important role in the mechanical properties of these films (elastic modulus and hardness).
Characterization test on nonlinear vibration of the fibre-reinforced composite thin plate
Authors: Li Hui , Wang Ziheng , Chang Yongle , Xu Zhonghao , Mou Chao
Published: July 2020

In this research, the characterization test on nonlinear vibration of a fibre-reinforced composite thin plate is studied. First, in order to improve the efficiency and precision of the test, a laser scanning vibration system is designed and developed. Then, test methods and procedures of the harmonic distortion and nonlinear time-varying damping of such thin plates are proposed from the time-domain perspective. Corresponding test methods and procedures of nonlinear vibration properties such as the hard/soft stiffness and amplitude-dependent damping are also presented from the frequency-domain perspective. Finally, the TC500 carbon fibre/resin composite plate is selected as an example for the research to carry out a case study. Potential nonlinear vibration phenomena of such plates are characterized by the proposed test methods. It has been proved that the related test system and techniques adopted in this paper can provide an important reference for the establishment of the nonlinear vibration test methodology of fibre-reinforced composite structures.
Better Executive Function Is Associated With Faster On-Transition Aerobic Metabolism Among Older Adults
Authors: Siline Ligita , Stasiulis Arvydas , Stasiule Loreta
Published: July 2020

The present study aimed to examine relationships between executive function (EF) and variables of aerobic fitness. Participants were 32 healthy older adults ( M age = 65.1, SD = 6.6 years). We measured the first ventilatory threshold (VeT1) and the kinetics of oxygen uptake ([Formula: see text]O2), heart rate (HR), and muscle deoxygenation [HHb] during treadmill walking of either constant, moderate intensity, or increasing intensity. We assessed EF with a computerized Stroop test and Stroop measures of correct answers, reaction time, and percent interference. We found the Stroop interference score to be negatively associated with the VeT1 ( r = –0.387, p = 0.031) and positively associated with the on-transition aerobic metabolism time constant (τ) of HR ( r = 0.519, p = 0.003), [Formula: see text]O2 ( r = 0.454; p = 0.010), and [HHb] ( r = 0.644, p = 0.001). Correct responses were negatively related with τHR ( r = –0.372, p = 0.039) and τ[Formula: see text]O2 ( r = –0.500, p = 0.004). The Stroop average reaction time, congruent reaction time and incongruent reaction time were positively related to τ[HHb] ( r = 0.507, p = 0.010; r = 0.437, p = 0.029; r = 0.558, p = 0.004, respectively). Better EF was associated with faster on-transition aerobic metabolism and higher aerobic fitness among older adults.
Application of five continuous distributions and evaluation of wind potential at five stations using normal distribution
Authors: Sumair Muhammad , Aized Tauseef , Gardezi Syed Asad Raza , Bhutta Muhammad Mahmood Aslam , Rehman Syed Muhammad Sohail , Rehman Syed Ubaid ur
Published: July 2020

Application of Weibull distribution in a generalized way to estimate wind potential cannot always be advisable. The novelty of this work is to estimate wind potential using Normal probability density function. A comparison of five probability distributions namely Normal, Gamma, Chi-Squared, Weibull, and Rayleigh was done using three performance evaluation criteria. Four years (2015–2018) hourly wind data at 50 m height at five stations near the coastline of Pakistan was used. It was found that normal distribution gives the best fit at each of these stations and against each evaluation criterion followed by Weibull distribution while Rayleigh distribution gives the poorest fit. Further energy generation by fifteen turbine models was calculated and GE 45.7 was found the best in terms of amount of energy generation and capacity factors while Vestas V42 shows the worst. However, GE/1.5 SL is the most economical while Vestas V63 is the least. Among five locations, Shahbandar is the best potential site while Manora is the least.
Symmetric and asymmetric effects of financial development on carbon dioxide emissions in Nigeria: Evidence from linear and nonlinear autoregressive distributed lag analyses
Authors: Omoke Philip C , Opuala-Charles Silva , Nwani Chinazaekpere
Published: July 2020

This study examines the impact of financial development on carbon dioxide emissions in Nigeria over the period 1971–2014. Income per capita, energy consumption, exchange rate and urbanization are incorporated in the analysis. The empirical analysis based on linear and nonlinear autoregressive distributed lag techniques provides evidence of long-run relationship among the variables in Nigeria. The results in general show that financial development has significant asymmetric effects on carbon dioxide emissions in Nigeria. Both short-run and long-run analyses show that the impact of positive changes in financial development on carbon dioxide emissions is significantly different from that of negative changes. The results suggest that in Nigeria positive shocks in financial development have significant reducing effect on carbon dioxide emissions, while negative shocks in financial development have significant increasing effect on carbon dioxide emissions. The empirical results also show that the response of carbon dioxide emissions to negative shocks in financial development is stronger. Based on these findings, this study concludes that mitigation policies would need to incorporate strategies to strengthen the depth of financial intermediation in the Nigerian economy.
A new automated system for the preparation of sclerosant foam: A study of the physical characteristics produced and the device settings required
Authors: Roche Enric , Pons Ramon , Roche Oriol , Puig Antoni
Published: July 2020

Objectives

To determine the quality of sclerosant foam produced with an automated preparation system with multiple combinations of sclerosing agents, gases, and device settings.

Methods

Single-use mixing capsules filled with air or O2/CO2 and polidocanol (0.25, 1, or 3%) or sodium tetradecyl sulfate (0.2 or 1%) were coupled to a customized magnetic stirrer. Stirring speed and time were adjusted between 1500 and 4000 r/min and 30 and 60 s, respectively, and characteristics of the foam produced were measured: half-life, bubble diameter, and gas-to-liquid ratio.

Results

With optimized device settings, the following foam characteristics were obtained: half-life range, 1.4 ± 0.9 to 5.2 ± 0.6 min; bubble diameter, 84 ± 14 to 119 ± 6 µm; and gas-to-liquid ratio, 5:1–7:1. Sodium tetradecyl sulfate foam was quicker to form than polidocanol but faster to degrade. Foams with low sclerosant concentrations and O2/CO2 required higher speed and longer time.

Conclusions

Suitable foam characteristics could be obtained with all combinations of sclerosing agent, concentration, and gas.
Non-contrast-enhanced magnetic resonance imaging: Objective figures in differentiation between acute and chronic deep venous thrombosis in the lower extremities
Authors: Kao Chih-Chen , Chen Chien-Wei , Tseng Yuan-Hsi , Tsai Yuan-Hsiung , Wang Shih-Chung , Huang Yao-Kuang
Published: July 2020

Background

Deep vein thrombosis is a severe health problem. Treatment options may differ between acute and chronic deep vein thrombosis. Thus, distinguishing acute from chronic deep vein thrombosis is essential for patients with deep vein thrombosis. Triggered angiography non-contrast enhanced is an innovative magnetic resonance imaging protocol that may provide objective evidence in differentiating acute from chronic deep vein thrombosis.

Method

We prospectively collected information on consecutive patients who had been evaluated through triggered angiography non-contrast enhanced magnetic resonance imaging for venous pathology in their lower extremities at a vascular wound care center in a tertiary hospital between April 2017 and January 2020. Patients included were divided into two groups with the onset time cutoff point of 21 days. All were undergone non-contrast-enhanced magnetic resonance imaging evaluation. Non-contrast-enhanced magnetic resonance imaging images were evaluated by a radiologist, and lower extremity venous thrombosis, collateral-vein development, and subcutaneous honeycombing were emphasized. Cohen’s kappa coefficient was used to measure interrater agreement between the development of collateral veins, subcutaneous honeycombing, and symptom onset over 21 days.

Results

Interrater agreement analysis revealed that the development of collateral veins was substantially correlated with the onset of symptoms over 21 days (Table 1). Additionally, the development of subcutaneous honeycombing detected through triggered angiography non-contrast enhanced magnetic resonance imaging also substantially agreed with the onset of symptoms over 21 days (Table 2).

Conclusion

The diagnostic power of triggered angiography non-contrast enhanced magnetic resonance imaging in deep vein thrombosis is rival to current gold standard, color Doppler sonography. Triggered angiography non-contrast enhanced magnetic resonance imaging provides objective information on onset timing in patients with deep vein thrombosis that could differentiate acute from chronic deep vein thrombosis and provides guidance for treatment planning.
How Travel Purpose Interacts with Predictors of Individual Driving Behavior in Greater Montreal
Authors: DeWeese James , El-Geneidy Ahmed
Published: July 2020

Rising transport emissions represent a significant challenge for policy makers. Two principal options exist to reduce emissions: make driving less polluting or reduce driving overall. Though cities have a role to play in both approaches, the levers that may influence the latter more squarely align with municipal competences concerning the urban form. This paper aims to refine our understanding of the relationship between urban form, public transport systems, and driving behavior by exploring whether accessibility—the ease of reaching desired destinations—exerts a different influence on people’s decision to drive on weekdays and total distance driven depending on travel purpose. We relied on disaggregate data from the 2013 Montreal Origin–Destination Survey and employed a two-step “hurdle” approach with multilevel logistic and linear models. We found both local and regional accessibility displayed statistically significant negative correlations with driving mode choice and vehicle distance driven by drivers. Concerning the decision to drive, regional accessibility, defined by transit-accessible jobs, appeared to possess a stronger relationship than local, as measured by Walk Score across all purposes. When considering total kilometers driven, however, the relative impact of both types of accessibility varied. Overall, and for work and school driving, regional accessibility correlated with the greatest declines in distance driven. For healthcare and discretionary travel, local accessibility correlated with a larger decline in total driving distance. Our findings also highlight the potentially profound impact of other explanatory factors, particularly car ownership, suggesting additional policy approaches for municipal decision makers to reduce vehicle kilometers traveled.
Integrating Economic and Utility Concepts for a Comprehensive Bridge Valuation Model
Authors: Hoang Trinh , Han Zhe , Zhang Zhanmin
Published: July 2020

Current approaches in bridge valuation mostly focus on engineering construction costs while neglecting other values generated by the bridge's functionality and utilization, along with other indirect economic values of a bridge. Such limitations prevent public agencies from capturing the true asset value of their bridges to make informed management decisions. The objective of this paper is to develop a comprehensive bridge asset valuation methodology that is based on the utility theory concept to better represent the asset value of a bridge. Various factors featuring the bridge asset value are characterized and considered in the model including physical condition, safety, mobility, average annual daily traffic (AADT), direct time savings, and so on. These factors are categorized into economic value and utility-based value and quantified with specific performance measures. The applicability of the proposed methodology is demonstrated through a case study using five real-world bridges in Austin, Texas. The results show that the integrated, comprehensive model is able to effectively evaluate the overall asset value of a bridge. Finally, the paper discusses how public agencies can take advantage of the evaluation results to better understand bridge asset value and make more insightful decisions in bridge management practice.
Interrelationship of Posttraumatic Stress, Hassles, Uplifts, and Coping in Women With a History of Severe Sexual Abuse: A Cross-Sectional Study
Authors: Stensvehagen Marianne Torp , Bronken Berit Arnesveen , Lien Lars , Larsson Gerry
Published: July 2020

Experiencing trauma, such as sexual abuse, increases the risk of a negative health outcome. The aim of the present study was to compare two groups of female survivors of sexual abuse, one group with a lower indication of posttraumatic stress disorder (L-PTSD) and one with a higher indication of posttraumatic stress disorder (H-PTSD). We hypothesized that, with a history of sexual abuse, higher levels of PTSD symptoms would be associated with more daily hassles, fewer daily uplifts, and more maladaptive coping strategies, and that there would be more reporting of severe types of sexual victimization, less resourceful socioeconomic conditions and a lower level of emotional stability. A questionnaire, including measures of socioeconomic conditions, trauma experience, emotional stability (the Single-Item Measures of Personality), Posttraumatic Stress Disorder Checklist (PCL), daily hassles and uplifts (the Stress Profile), and coping strategies (the Brief Coping Orientation to Problems Experienced [COPE] questionnaire), was completed by 57 female users at nine support centers for survivors of incest and sexual abuse in Norway. The results show that the H-PTSD group reported significantly more daily hassles, fewer daily uplifts, and more use of maladaptive coping strategies. The L-PTSD group reported more emotional stability, fewer daily hassles, and more uplifts, and used more adaptive coping strategies. However, few differences were found between the H-PTSD and the L-PTSD groups with regard to severity of sexual abuse and socioeconomic conditions. The results on the hassle, uplift, and coping scales are potentially interesting from an interventional point of view. Major life events such as sexual abuse may be out of control for the afflicted victim. Appraisal of and coping with everyday events, however, can be affected and offer interesting possibilities for interventions directed at the survivor, her significant others, and professional helpers.
Determining the Existence and Strength of Teen Dating Violence Policy: Testing a Comparative State Internal Determinants Model
Authors: Black Beverly , Ravi Kristen , Hoefer Richard
Published: July 2020

Research demonstrates that Teen Dating Violence (TDV) programs impact TDV knowledge, attitudes, and behaviors, decreasing the odds of TDV victimization and perpetration. Studies indicate that students who do not complete a TDV intervention have significantly higher odds of physical and emotional TDV victimization and emotional TDV perpetration. This study uses multiple logistic regression and multiple linear regression to examine predictors of the presence and the strength of state legislation addressing TDV education and school policies. Results indicate some success in predicting the existence of TDV laws but less support for forecasting the strength of the policies passed. Dominant political party and state median income were found to be potentially important determinants of TDV state school policies. A state’s political culture influenced the strength of states’ TDV policies. Showing that policy existence and strength are related to different processes is important for advocates to understand. Future research should look at additional variables and explore legislative histories.
An improved particle swarm optimization algorithm and its application in solving forward kinematics of a 3-DoF parallel manipulator
Authors: Zhang Shuzhen , Yuan Xiaolong , Docherty Paul D , Yang Kai , Li Chunling
Published: July 2020

This paper proposes an improved particle swarm optimization to study the forward kinematic of a solar tracking device which has two rotational and one translational degree of freedom. The forward kinematics of the parallel manipulator is transformed into an optimization problem by solving the inverse kinematics equations. The proposed method combines inertial weight with the iterations number and the distance between current swarm particles and the optimum to improve convergence ability and speed. The novel cognitive and social parameters are adjusted by the inertia weight to enhance unity and intelligence of the algorithm. A stochastic mutation is used to diversify swarm for faster convergence via local optima evasion in high dimensional complex optimization problems. The performance of the proposed method is demonstrated by applying it to four benchmark functions and comparing convergence with three popular particle swarm optimization methods to verify the feasibility of the improved method. The behaviors of the proposed method using variable cognitive and social parameters and fixed value are also tested to verify fast convergence speed of variable parameters method. And further, an application example uses the method to determine the forward kinematics of a three-degree-of-freedom parallel manipulator. Finally, the mechanism simulations model of the parallel manipulator are carefully built and analyzed to verify the correctness of the proposed algorithm in PTC Creo Parametric software. In all cases tested, the proposed algorithm achieved much faster convergence and either improved or proximal fitness values.
Influence of Needs and Experiences of Haemato-Oncology Patients on Acceptability of a Telephone Intervention for Support and Symptom Management: A Qualitative Study
Authors: Liptrott Sarah J. , Lovell Karina , Bee Penny
Published: July 2020

Healthcare technologies are increasingly used to address the unmet needs of patients with cancer; however new service developments must be acceptable to patients. The objective of this study was to determine the unmet needs of haemato-oncology patients and their influence on the perceived acceptability and participation in a telephone intervention delivering. A qualitative study was designed interviewing 20 participants having received the intervention. Data were analysed inductively and deductively using Framework Analysis. Three core themes emerged: (1) fluctuations in emotional distress and coping across the cancer trajectory with evidence of adaptive and maladaptive coping; (2) potential deficits in patient support, continuity of care and information provision; and (3) intervention acceptability analysis underpinned by the Theoretical Framework of Acceptability showed acceptability was influenced by participants’ subjective illness contexts and unmet needs.

This work contributes to understanding of personal context as a determinant of intervention acceptability in order to enhance implementation strategies.
Examining Student Perceptions of Tobacco Policy Enforcement on College Campuses in Texas
Authors: Grossberg Lou Ann , Loukas Alexandra , Fernandez Alejandra , Latimer Lara A. , Karn Shelley
Published: July 2020

Background. Colleges across the country are adopting tobacco-free policies to prevent and decrease tobacco use among college-aged young adults. Aims. This study examines differences between nontobacco, single-product, and polytobacco users’ perceptions of the importance of enforcing tobacco-free policies, support for various enforcement strategies, and success of policy enforcement on campuses. Method. A Kruskal-Wallis test was conducted to examine group differences on the importance of enforcing polices, support for enforcement strategies, and success of policy enforcement among 10,351 students attending 10 Texas colleges. Results. Findings show significant group differences on all dependent variables. Post hoc tests indicated that nontobacco users reported the most favorable responses, followed by single-product users, then polytobacco users. Discussion. Despite group differences, findings show all students feel it is important to enforce tobacco policies and support enforcement strategies but believe current campus enforcement efforts are only moderately successful. Conclusions. Findings may prompt administrators to adopt policy enforcement strategies to curb tobacco use on campuses.
Reproducibility and variable precision computing
Authors: Bailey David H
Published: July 2020

Recently some scientific computing users have discovered that they can replace 64-bit with 32-bit operations for carefully selected portions of the computation, and still retain acceptable accuracy in the final results. In addition, developers of some emerging applications such as machine learning have discovered that they can achieve acceptable results with only 16-bit precision in certain portions of the code. At the other end of the precision spectrum, some users have explored using 128-bit arithmetic in some particularly demanding applications, while others have done computations using much higher precision—hundreds or even thousands of digits. Such work has underscored the need to develop new mathematical and software frameworks to support a dynamically variable level of precision, and, more generally, to rethink what “reproducibility” means in a variable precision environment. This article summarizes some of the work being done in this arena, and lists research problems that need to be solved.
Direct extraction of fibre from a ramie bark
Authors: Li Zhengfan , Zou Yanling , Li Siyu , Guo Yuwei , Zeng Xinyi , Zhu Jingguo , Zhang Shangyong
Published: July 2020

In this research, a new method was developed for extracting fibre directly from the ramie. High-speed water treatment was found to be beneficial for the removal of husks. The proposed fibre extraction process included retting, first high-speed water treatment, oxidative degumming and second high-speed water treatment. The retting time and hydrogen peroxide concentration suitable for the removal of husks were found to be 7 days and 8 g/L, respectively. There was very little residual husk in the extracted sample. Scanning electron microscopy showed that most of the gums were removed. The fineness and tenacity values of the ramie fibre that was extracted using the proposed method were close to the values of the ramie fibre extracted by using the traditional process. As compared with the traditional process, the chemical agent consumption, boil time and labour intensity of the new extraction method were less.
A phase II trial of the FGFR inhibitor pemigatinib in patients with metastatic esophageal–gastric junction/gastric cancer trastuzumab resistant: the FiGhTeR trial
Authors: Merz Valeria , Zecchetto Camilla , Simionato Francesca , Cavaliere Alessandro , Casalino Simona , Pavarana Michele , Giacopuzzi Simone , Bencivenga Maria , Tomezzoli Anna , Santoro Raffaela , Fedele Vita , Contarelli Serena , Rossi Irene , Giacomazzi Serena , Pasquato Martina , Piazzola Cristiana , Milleri Stefano , de Manzoni Giovanni , Melisi Davide
Published: July 2020

Background:

Prognosis of patients affected by metastatic esophageal–gastric junction (EGJ) or gastric cancer (GC) remains dismal. Trastuzumab, an anti-HER2 monoclonal antibody, is the only targeted agent approved for the first-line treatment of patients with HER2-overexpressing advanced EGJ or GC in combination with chemotherapy. However, patients invariably become resistant during this treatment. We recently identified the overexpression of fibroblast growth factor (FGF) receptor 3 (FGFR3) as a molecular mechanism responsible for trastuzumab resistance in GC models, providing the rationale for the inhibition of this receptor as a potential second-line strategy in this disease. Pemigatinib is a selective, potent, oral inhibitor of FGFR1, 2, and 3.

Methods:

The FiGhTeR trial is a phase II, single-arm, open-label study to assess safety and activity of the FGFR inhibitor pemigatinib as second-line treatment strategy in metastatic EGJ/GC patients progressing under trastuzumab-containing therapies. The primary endpoint is the 12-week progression-free survival rate. Plasma and tumor tissue samples will be collected for translational research analyses at baseline, during treatment, and at progression on pemigatinib.

Discussion:

Co-alterations in genes coding for different tyrosine-kinase receptors are emerging as relevant mechanisms of acquired resistance to anti-HER2 therapeutic strategies in GC. In particular, our group has recently identified that in GC models the overexpression of FGFR3 sustains the acquired resistance to trastuzumab. This trial aims to assess the safety, tolerability and activity of the FGFR inhibitor pemigatinib as a second-line treatment in metastatic EGJ/GC patients refractory to first-line trastuzumab-containing therapies. Furthermore, this study offers the opportunity to prospectively study mechanisms and pathways involved in trastuzumab resistance.

Protocol number:

CRC2017_02

EudraCT Number:

2017-004522-14
Radiologic Analysis of Balloon Sinuplasty in a Human Cadaver Model: Observed Effects on Sinonasal Anatomy
Authors: Lopez Erin M. , Farzal Zainab , Norris Meghan , Canfarotta Michael W. , Pappa Andrew K. , Santarelli Griffin D. , Hernandez Stephen C. , Thorp Brian D. , Senior Brent A. , Zanation Adam M. , Ebert Charles S. , Kimbell Julia S. , Kimple Adam J.
Published: July 2020

Background

Balloon sinuplasty is increasingly used in the outpatient clinic for treatment of chronic rhinosinusitis, but radiologic analysis of its effects on sinonasal anatomy is largely uncharacterized in the known literature.

Objective

The purpose of this study is to examine the anatomic effects of balloon sinuplasty in a cadaveric model.

Methods

Five fresh cadaver heads underwent sequential endoscopic balloon dilation of maxillary ostia, frontal recess outflow tracts, and sphenoid ostia bilaterally by fellowship-trained rhinologists. Pre- and post-procedural CT imaging was obtained. CT scans were imported into Mimics™ software and sinonasal anatomy was analyzed systematically.

Results

Visual confirmation of balloon dilation was achieved in all 3 sites bilaterally in each cadaver. Radiologic analysis demonstrated that the frontal sinus outflow tract was appropriately dilated 60% (6/10 sites) of the time while the agger was inadvertently dilated 30% of the time (3/10). The sphenoid os was successfully dilated 70% (7/10 sites) of the time. In two cases, a posterior sphenoethmoid (Onodi) cell was dilated instead of the sphenoid. Successful dilation of maxillary os was noted 60% of the time (6/10 sites). No significant change in maxillary os was noted after balloon dilation. Normal middle turbinates were significantly medialized following balloon dilation 75% (6/8 sites) of the time.

Conclusions

While the goal of balloon sinuplasty is to improve natural sinonasal drainage by dilating existing outflow tracts, as evidenced by radiologic evaluation the procedure appears not to achieve this in all cases, while occasionally creating unintended changes in sinonasal anatomy as well. These unrecognized changes in anatomy may be responsible for the post-procedure change in symptomatology that some patients experience.
The Covers of Young Adult Novels and Their Graphic Novel Adaptations: A Qualitative Multimodal Content Analysis
Authors: Kachorsky Dani , Reid Stephanie F.
Published: July 2020

Drawing from theories of visual culture, social semiotics, and multimodality, the researchers conducted a qualitative multimodal content analysis of the covers of 21 young adult (YA) books that had been adapted as graphic novels (GNs). This study showed that the GN covers emphasized character and that the ages of the represented characters seemed to shift during the process of adaptation. However, publishers linked the two covers through branding, color schemes, and visual elements. These findings suggest that publishers view the readership of GNs differently than the readership of YA novels. This article encourages literacy education researchers and classroom practitioners to support students in analyzing visual artifacts designed for particular consumers. Critical readers could examine the sites of production and dissemination in addition to the text itself.