bluuebunny/crossref_metadata_2025 huggingface dataset:
Hemangioma cutâneo canino tratado com Parvulan® (Cutibacterium acnes): Relato de caso
Authors: Silva Francisca
Published: July 2022

Immunomodulators are substances that act on the immune system by modulating various functions of the innate or acquired immune response. One of these immunomodulators is Cutibacterium acnes (C. acnes), an active agent of Parvulan®. The aim of this case report is to expound on the application of C. acnes as an immunomodulator in the treatment of a dog affected by benign hemangioma in the perineal region. The thirteen-year-old male animal, of no defined breed (NDB), presented a dark nodule, measuring 2.0 cm in diameter. A biopsy of the nodule was performed for diagnosis and confirmation of hemangioma. Treatment started with 0.3 ml doses of Parvulan® with intramuscular (IM) applications. In the first month, there was a 35% (0.7 cm) regression of the tumor. In the second phase of the treatment, applications were made once a week for 2 months. During this period there was a regression of 45% (0.9 cm) of the tumor, and after three months 65% (1.3 cm). In the third phase, Parvulan® was applied every 15 days for two months. In the course of this period, a 100% regression concerning the initial value was obtained. Throughout the entire treatment (approximately 5 months) the tumor completely regressed, with the nodule disappearing. The results showed the efficiency of C. acnes lysate in the treatment of canine cutaneous hemangioma, being an alternative to non-surgical intervention with no tumor recurrence. However, it is necessary to carry out more studies with other dogs that present a diagnosis of hemangioma in order to obtain a more accurate and precise protocol.
Uso de probióticos e seus efeitos no bem-estar de aves de produção de ovos
Authors: Frozza Rogerio , Inoue Alberto , Paz Ibiara , Guzzi Marlon , Gomide Sergio , Jacinto Andressa , De Lima Daniele
Published: July 2022

The gut microbiota plays a key role in the immune response, in pathogens inhibition in addition to stimulating the central nervous system through neuroendocrine and immune systems. So, the inclusion of bacillus-based probiotics in the diet of laying hens promotes the stability of the microbiota, and improves digestibility and nutrient utilization, resulting in better productivity and egg quality. It also enables the synthesis and release of serotonin, promoting a feeling of well-being in laying hens and reducing their stress. The objective of the study was to determine the effect of GalliPro®MS supplementation in laying hens, in relation to productivity and egg quality indices, as well as their behavior. There was a improvement in egg production and a reduction of cracked and dirty eggs (P < 0.05). GalliPro®MS influenced significantly in the reduction of the agonistic behavior and aggressiveness as well as reduction of feather pecking and reduction of fights. There was also a reduction in mortality in the group that received the inclusion of the probiotic.
Brucelose suína no estado do Maranhão: prevalência em locais de abate sem serviço de inspeção sanitária
Authors: Lustosa Cavalcante Analy
Published: July 2022

Raising subsistence pigs is common in the state of Maranhão. Most of the time, this creation is mixed with cattle, canines and birds, being represented by loose animals, fed with leftovers of human food, with precarious slaughter, without sanitary inspection, exposed to the risk of contamination with pathogenic agents. Among the diseases that can affect the swine herd, brucellosis, an infectious disease caused by bacteria of the genus Brucella, which produces chronic infection in animals, can also infect humans, one of the most important and widespread zoonoses worldwide. Given this scenario, the objective of the study was to estimate the prevalence of anti-Brucella spp. in pigs slaughtered in slaughterhouses without inspection service. 224 swine serum samples were evaluated by the Buffered Acidified Antigen (AAT) screening test and confirmed by means of 2-Mercaptoethanol (2-ME) combined with Slow Seroagglutination (SAL). In the AAT test, 30/224 (13.39%) samples presented agglutination reaction in a total of 9/12 (75%) municipalities. In the 2-ME test, 3/224 (1.34%) samples were considered inconclusive and 12/224 (5.36%) positive samples in a total of 6/12 (50%) municipalities. These results demonstrate the presence of Brucella spp. in the swine species in the state of Maranhão which, in addition to being an imminent risk to public health, could harm the main objective of the National Program for the Control and Eradication of Brucellosis and Tuberculosis in cattle and buffaloes: the eradication of the disease.
Avaliação in vitro da segurança e eficácia de nutracêutico à base de alecrim para a pele de cães
Authors: Brunel Hilana
Published: July 2022

The skin is the main barrier against friction, pathogens, excessive loss of water and also has an important role in thermoregulation and receptors that allow the perception of pain, touch, temperature and pressure. The nutrients present in food are extremely necessary for the maintenance of healthy of skin and hair, however, in most diets these nutrients are not enough, so supplementation with nutraceuticals becomes important. Nutraceuticals that contain natural ingredients in their formulation are increasing in the market, as is the case of the product analyzed in the present study, which contains rosemary, pumpkin seed, omega 3 and caviar phospholipids in its formulation. The objective of the present experiment was to evaluate the in vitro action of a nutraceutical for skin (DERM) on mesenchymal stem cells regarding the alteration in the production of IL-6 and IL-10 cytokines and the safety of the product in relation to the possibility of causing mutations in cells of animals that consume it. The pro-inflammatory cytokine IL-6 decreased (P
Qualidade de água e resistência de alevinos no transporte em sacos plásticos: Oreochromis niloticus e Colossoma macropomu
Authors: Silva Felipe de Jesus Pires da Silva , De Souza Lucas Setubal , Da Gama Melo Jose Douglas
Published: July 2022

The objective of this work was to understand the impacts that the fingerlings Oreochromis niloticus and Colossomoma macropomum feel when transported in plastic bags, reporting the effect of time and density according to the results obtained in the analyzed works. As this is a literature review, seven articles published between 2000 and 2021 were selected, which discuss the physiological impacts of fingerlings when transported in plastic materials. This is because the water conditions and the transport period can directly affect the life span of the fingerlings, since the hydrogenic potential - pH, water quality and physiological factors are directly affected. Thus, the period of contact of the fingerlings in the plastic container, according to the studies, cannot exceed 8 consecutive hours, since changes in pH, temperature and dissolved oxygen interfere with the survival capacity of the specimens. Therefore, the zootechnician needs to understand the maximum period that a fingerling can remain in a plastic container and advise on changing the container if it takes longer than 8 hours to reach the destination.
Inventarisasi dan Revitalisasi Pengelolaan Perpustakaan Sekolah Dasar Negeri (SDN) di Kecamatan Tambun Selatan Bekasi
Authors: Silalahi Ratna Suminar , Dewi Nita Komala , Komariah Neng Siti
Published: July 2022

Rakyat Indonesia mempunyai kesempatan yang sama untuk memperoleh pendidikan, dalam ini juga sebagai tujuan pemerintah Indonesia untuk mencerdaskan kehidupan bangsa. Pendidikan formal dalam sistem pendidikan di Indonesia dimulais dari Sekolah Dasar (SD). Salah satu alat bantu untuk pencapaian tujuan pendidikan bagi anak SD dengan memotivasi kemauan membaca bukusejak dini. Analisis situasi pada aktifitas pengabdian akademik ini sebagai berikut: Salah satu Sekolah Dasar Negeri (SDN) di Kecamatan Tambun Selatan, Bekasi, memiliki perpustakaan sebagai salah satu fasilitas pendidikan. Berkaitan dengan peristiwa pandemi Covid-19, perpustakaan ini menjadi tidak diperhatikan. Fungsi berubah menjadi ruang penyimpanan barang, dikarenakan hanya ruang ini yang tidak dimanfaatkan. Perpustakaan sekolah perlu dilakukan revitalisasi agar sumber daya yang dimiliki dapat lebih dimanfaatkan secara maksimal oleh siswa pada saat aktivitas pembelajaran kembali dimulai. Program pengabdian masyarakat bersama mahasiswa membantu sekolah untuk melakukan revitalisasi perpustakaan agar perpustakaan dapat berfungsi kembali dan menjadi pojok baca yang menyenangkan. Permasalahan yang terjadi dikarenakan: 1) adanya keharusan untuk pembatasan jarak dalam beraktivitas, sehingga cenderung aktivitas lebih banyak dilakukan di rumah dengan pemanfaatan teknologi informasi, sehingga selama dua tahun aktivitas sekolah dilakukan secara daring; 2) akibat dari pandemi Covid-19 kegiatan siswa tidak menggunakan fasilitas sekolah; 3) perpustakaan SDN menjadi rubah fungsi dan tidak mendapat perhatian khusus sebagai tempat membaca dan meminjam buku; 4) banyak buku-buku yang sudah berdebu dan rusak; 5) ruang perpustakaan menjadi kurang nyaman untuk digunakan.Perpustakaan sudah perlu dibenahi agar dapat dimanfaatkan kembali sebagaimana fungsinya. Situasi ini yang memotivasi pelaksanaan pengabdian masyarakat bersama dengan mahasiswa bersamaan dengan program Kuliah Kerja Nyata (KKN) dengan melakukan program revitalisasi ruang perpustakaan SDN di Kecamatan Tambun Selatan, Bekasi.  Solusi permasalahan SDN di Kecamatan Tambun Selatan, Bekasi dilakukan dalam beberapa tahap, seperti melakukan inventarisasi sumber daya yang sudah ada dan sesuai kebutuhan, revitalisasi (membongkar, memperbaiki dan membersihkan kembali) ruang perpustakaan, merubah tata letak dan sirkulasi peminjaman buku, membuat lahan literasi lainnya, sumbangan buku. Kegiatan ini dilakukan dalam waktu satu bulan. Luaran yang dihasilkan dalam program pelaksanaan revitalisasi perpustakaan SDN di Kecamatan Tambun Selatan, Bekasi antara lain; 1) laporan; 2) buku modul non publikasi, 3) publikasi jurnal pengabdian kepada masyarakat dengan judul Inventarisasi dan Revitalisasi Pengelolaan Perpustakaan Sekolah Dasar Negeri di Kecapatan Tambun Selatan, Bekasi.
Penyuluhan Kesadaran Masyarakat Berwawasan Lingkungan di Desa Sukatenang Kecamatan Sukawangi Kabupaten Bekasi
Authors: Prasmoro Alloysius Vendhi , Supratman Jasan , Sitorus Helena , Spalanzani Widya
Published: July 2022

Permasalahan lingkungan hidup merupakan salah satu kewajiban manusia untuk dapat dikelola sebagaimana mestinya menurut amanah Tuhan Yang Maha Kuasa, sehingga setiap insan manusa memiliki tanggung jawab terhadap kelangsungan lingkungan hidup. Dalam kenyataan sekarang ini terjadinya pemanasan global yang semakin meningkat dapat mengakibatkan perubahan iklim sehingga dapat memperparah penurunan kualitas lingkungan hidup. Berdasarkan hal tersebut perlu dilakukan perlindungan dan pengelolaan lingkungan hidup, agar lebih menjamin kepastian hukum dan memberikan perlindungan terhadap hak setiap orang untuk mendapatkan lingkungan hidup yang baik dan sehat. Dalam mewujudkan realisasi kesehatan lingkungan, diperlukan peran aktif masyarakat dalam pencapaian pembangunan kesehatan lingkungan. Hal ini berarti bahwa pembangunan hanya akan terlaksana apabila dilakukan dengan keterlibatan seluruh lapisan masyarakat sesuai dengan potensi yang dimiliki masing-masing. Desa Sukatenang merupakan salah satu Desa yang berada di Kecamatan Sukawangi Kabupaten Bekasi.memiliki kurang lebih jumlah penduduk 11.056 jiwa. Penataan lingkungan di Desa Sukatenang ini sudah cukup tertata rapi,tetapi masih terlihat adanya sampah di pinggir jalan serta lahan kosong. Melihat profil Desa Sukatenang seperti di atas, maka dapat disusun program kegiatan yang merujuk pada peran dosen dan mahasiswa sebagai pelaku akademisi untuk memajukan warga desa yang berpendidikan dan berwawasan lingkungan. Dalam pelaksanaanya dilakukan Penyuluhan Kesadaran Masyarakat Berwawasan Lingkungan. Sebelum penyuluhan dilakukan, warga Desa Sukatenang Kecamatan Sukawangi Kabupaten Bekasi memiliki tingkat wawasan lingkungan yang kurang. Dengan adanya “Program Penyuluhan Kesadaran Masyarakat Berwawasan Lingkungan Di Desa Sukatenang”. Masyarakat menunjukkan perubahan perilaku hidup sadar lingkungan dan diharapkan selalu dapat diterapkan di desa Sukatenang ini dan bisa dicontoh oleh desa-desa lainnya.
Znaczenie egzaminu radcowskiego dla zapewnienia odpowiedniego poziomu kwalifikacji radcy prawnego. Glosa do wyroku Naczelnego Sądu Administracyjnego z dnia 18 sierpnia 2020 r., II GSK 30/18
Authors: Kępa Monika
Published: July 2022

Glosowany wyrok Naczelnego Sądu Administracyjnego z dnia 18 sierpnia 2020 r., sygn. II GSK 30/18, dotyczy poziomu kwalifikacji merytorycznych kandydata do zawodu radcy prawnego. NSA sformułował tezę, że powinny być one jak najwyższe, aby zapewnić prawidłowe wykonywanie tej profesji. Zarówno tezę, jak i prowa­dzącą do niej argumentację należy zaaprobować. Z uwagi na to, że czynności składające się na świadczoną przez osoby wykonujące zawód zaufania publicznego pomoc prawną mają zróżnicowaną postać i rozległy zakres, konieczne jest posiadanie odpowiedniej wiedzy i umiejętności. Minimalny osiągnięty przez kandydata poziom kwalifikacji wyrażony pozytywnym wynikiem egzaminu powinien oznaczać wypełnienie wszystkich stawianych radcy prawemu wysokich wymagań. Celem egzaminu zawodowego jest dopuszczenie do wykonywania zawo­du radcy prawnego osób, które będą reprezentowały wysoki poziom przygotowania zawodowego, co w szer­szym kontekście stanowi ochronę interesu publicznego.
Tratamiento endovascular e indicadores predictivos de complicaciones y mortalidad en la hemorragia subaracnoidea espontanea de origen aneurismática
Authors: Criollo P. Jefferson , Mora Henin , Cruz Karina , Torres Larry , Cedeño Wilmer , Solá Juan , Castañeda Judy
Published: July 2022

Introducción: La causa más frecuente de hemorragia subaracnoidea espontánea es la ruptura aneurismática (75-80 %), con una elevada tasa de mortalidad 40-50 %. Objetivo: Determinar los principales indicadores predictivos de complicación y mortalidad en hemorragia subaracnoidea espontánea de origen aneurismático, en pacientes que recibieron tratamiento endovascular. Pacientes y métodos: Estudio prospectivo – retrospectivo, analítico, observacional de los pacientes con hemorragia subaracnoidea de origen aneurismático que recibieron tratamiento endovascular. Los datos obtenidos al ingreso hospitalario incluyeron edad, género, procedencia, escala de Glasgow, escala de Hunt y Hess, clasificación tomográfica de Fisher, complicaciones médicas, características del aneurisma, momento del tratamiento endovascular. Resultados: Se evaluaron 16 pacientes, 6 hombres (37,5 %)  y 10 mujeres (62,5%), con promedio de edad >61 años en  8 pacientes (50 %).Fallecieron 4 (25%) y sobrevivieron 12 (75 %). En la escala Fisher se obtuvo una mortalidad del 42,85 % en grado III correlacionándose con la escala de Hunt y Hess y escala de la federación mundial de neurocirugía grado V – IV, respectivamente, con una tasa de mortalidad del 100 %. La complicación más frecuente que se encontró es el vasoespasmo más isquemia, con un total de 43,75 % y una mortalidad de 28,57 %. Conclusión: Los factores que influyeron en el pronóstico de los pacientes con hemorragia subaracnoidea  fueron la edad y género. Se observó una relación directa en cuanto a las escalas de valoración clínicas e imagenologías con la mortalidad, a decir a mayor gradación a la escala mayor mortalidad.
Application of the cybernetic approach to price-dependent demand response for underground mining enterprise electricity consumption
Authors: Nikolaev Aleksandr , Vöth Stefan , Kychkin Aleksey
Published: July 2022

The article considers a cybernetic model for the price-dependent demand response (DR) consumed by an underground mining enterprise (UGME), in particular, the main fan unit (MFU). A scheme of the model for managing the energy consumption of a MFU in the DR mode and the implementation of the cybernetic approach to the DR based on the IoT platform are proposed. The main functional requirements and the algorithm of the platform operation are described, the interaction of the platform with the UGME digital model simulator, on which the processes associated with the implementation of the technological process of ventilation and electricity demand response will be simulated in advance, is shown. The results of modeling the reduction in the load on the MFU of a mining enterprise for the day ahead are given. The presented solution makes it possible to determine in advance the necessary power consumption for the operation of the main power supply unit, manage its operation in an energy-saving mode and take into account the predicted changes in the planned one (e.g., when men hoisting along an air shaft) and unscheduled (e.g., when changing outdoor air parameters) modes. The results of the study can be used to reduce the cost of UGME without compromising the safety of technological processes, both through the implementation of energy-saving technical, technological or other measures, and with the participation of enterprises in the DR market. The proposed model ensures a guaranteed receipt of financial compensation for the UGME due to a reasonable change in the power consumption profile of the MFU during the hours of high demand for electricity, set by the system operator of the Unified Energy System.
Remote sensing techniques in the study of structural and geotectonic features of Iturup Island (the Kuril Islands)
Authors: Talovina Irina , Krikun Nikita , Yurchenko Yurii , Ageev Aleksey
Published: July 2022

The article presents structural and geotectonic features of Iturup Island, the largest island in the Greater Kuril Ridge, a unique natural site, which can be considered as a geological reference. The structural and geotectonic analysis carried out on the basis of a comprehensive study of the new Earth remote sensing data, maps of anomalous geophysical geophysical fields, and other geological and geophysical materials using modern modelling methods made it possible for the first time to identify or clarify the location of previously discovered discontinuous faults, typify them and determine the kinematics, as well as to establish a more reliable spatial relationship of the identified structures with magmatism with the stages of the geological development of the region. The constructed diagram of the density distribution of the zones with increased tectonic fracturing shows a significant correlation between the distribution of minerals and weakened areas of  the Earth's crust and can be used as an alternative method for predicting minerals in the study region, especially in remote and hard-to-reach areas. The presented approach can be extended to the other islands of the Greater Kuril Ridge, thereby bringing research geologists closer to obtaining the answers to questions about the features of the geotectonic structure and evolution of the island arc. The use of customized software products significantly speeds up the process of interpreting a large array of geological and geophysical data.
Developing new polymeric nanoparticles for controlled release of quercetin as an alternative material protecting from COVID-19
Authors: TÜRKCAN Ceren
Published: July 2022

Research of drugs for COVID-19, the most striking studies include the ACE-2 receptors used by COVID-19 by binding to the lung cells for entry. In the researchers conducted, it was determined by the results of the docking studies performed on the agents that block the receptor by binding to the receptor, such as COVID-19, several molecules have the interest to bind to this receptor. One of these numbered molecules is herbal flavonoid called "Quercetin". In this study, quercetin imprinted polymeric materials were designed, synthesized and characterized. For synthesis, emulsion polymerization technique was used for obtaining quercetin imprinted polymeric materials. SEM and Zeta-Size analysis were used as preliminary characterization. After a week release experiment, quercetin imprinted polymeric nanoparticles were released by 14%. In the light of these results, it is predicted that quercetin printed polymeric material can be used for protection from COVID-19 and treatment of COVID-19 on the inhaler route.
Demografski, ekonomski i fiskalni učinci potpora razvoju brdsko-planinskih područja u Republici Hrvatskoj
Authors: Denona Bogović Nada , Drezgić Saša , Čegar Saša
Published: July 2022

U ovome radu prikazani su rezultati teorijskog i empirijskog istraživanja kojim su utvrđena dugoročna razvojna obilježja brdsko-planinskih područja u Republici Hrvatskoj, kao i učinci dosadašnjeg sustava potpore njihovom razvoju. Polazeći od teorijske i strateške razrade problematike razvoja brdsko-planinskih područja, svrha ovog istraživanja bila je analizirati ukupna demografska, ekonomska i fiskalna kretanja u brdsko-planinskim područjima Republike Hrvatske u usporedbi s prosječnim kretanjima na nacionalnoj razini. S tim u vezi, cilj istraživanja bio je kritički i empirijski ispitati učinkovitost i nedostatke dosadašnjeg sustava potpore razvoju brdsko-planinskih područja u kontekstu ostvarenja zakonski postavljenih ciljeva hrvatske regionalne politike. Rezultati provedenog istraživanja ukazuju na povećanje divergencije u cjelokupnom razvoju Republike Hrvatske i razvoju njezinih brdsko-planinskih područja, ali i na neučinkovitost državnih intervencija u zaustavljanju tog procesa. Ključni razlozi za to su relativno mala izdašnost državnih pomoći, zatim nedostatak kvalitetnih kriterija za njihovo dodjeljivanje te provedba neadekvatnih mjera i instrumenta za poticanje razvoja brdsko-planskih područja.
Success factor functional familiarity
Authors: Jerusalem Yannick , Blažková Ivana
Published: July 2022

The purpose of this paper is to consider the German stock market and develop a method for company valuation that complements the methods used to date. The paper elaborates on the novel construct of functional familiarity, consisting of board size, board fluctuation, diversity management, long-term incentive plans (LTIP) and research and development intensity, in relation to company performance. Company reports of MDAX-listed companies were collected and examined for the years 2013 to 2019. Based on the empirical investigation in the form of regression analyses, the statistically significant influence of the executive board size and board fluctuation, as well as of the LTIP, on the development of the share price could be demonstrated. The results indicate that the evaluation tool of functional familiarity in its current constellation identified three factors that should at least lead to a critical view of the stakeholder.
Earnings management and investor reaction
Authors: Salehi Mahdi , Malekinejad Amir , Abbaszadeh Mohammadreza
Published: July 2022

The purpose of the article is to investigate the contraction between the behavior of managers and investors toward Iran's capital market and the focus on agency theory which ends up with the conflict between the utilities of manages and investors because a conflict of interest implies an attempt to spread opportunistic behavior. In the current study, the benefit of reducing capital cost (manager's utility) and return on assets (investor's utility) are considered variables of interest of either party, in that Osborne's game theory was used in a two-step manner. The study population consisted of the companies listed on the Tehran Stock Exchange and Iran Over-the-Counter Market, classified in the game table according to managers' behavior toward high or low earnings management and investor's behavior toward acceptance non-acceptance of stock. The experimental results presented in this paper uphold the agency theory, indicating a conflict between managers and investors in Iran's capital market, particularly in the Tehran Stock Exchange. According to game theory, Nash's dominant equilibrium comes to the fore when dealing with the manager's low earnings management and investor's choice of strategy to accept a share in Iran's capital market and Tehran Stock Exchange. Alternatively, the presentation of transparent financial statements and the acceptance of such a company stock can maximize parties' utilities.
Replication model of integrated business development
Authors: Boichenko Kateryna
Published: July 2022

The purpose of this study is to form a replication model of integrated enterprise development and its testing at the enterprises of light industry in Ukraine. In this study, the integrated development of the enterprise is considered as a set of ways of interaction of internal and external determinants of performance efficiency of enterprises, ensuring optimal coordination, synchronization and coherence of funding relationships, taking into account economic, innovation, information and organizational benchmarks. The methodological tools of this study are based on the author’s approach to the formation of integrated development of companies based on the replication model. The formation of integrated development based on four directions (economic, innovative, informational and organizational), gives the enterprise an opportunity to use not only the advantages of the integrated company, but also to strengthen the weaknesses. The integrated development map of the companies under study is the navigating element of the proposed methodological approach. It allows identifying points for financial collision, not only taking into account the priority direction of development, but also the level of integration.
Economic and mathematical model of enterprise client base management
Authors: Harkavenko Vladyslav , Stets Olena
Published: July 2022

Despite a fairly wide range of developed models for customer base management, the practice of implementing full-fledged customer base management models of the company is quite small. This is primarily due to the complexity and high cost of implementing a comprehensive model of managing the company’s customer base. The problem also lies in the limitations of the models themselves. Typically, the need to manage their company’s customer base arises in companies with a customer base of several thousand to millions of customers. In this case, the implementation of methods and approaches aimed at managing one client is not rational, and you need models adapted to work with groups of clients. An important limitation in existing research are the parameters of clustering the client base. Most authors suggest that the number of purchases and the age of the last purchase by the customer be considered as a criterion for division into groups of customers. This does not take into account such parameters of customer purchasing behavior as the amount of purchases, the value of the customer to the company and the time of interaction between the customer and the company.
Dynamic Context Driven Re-configurable Business Process
Authors: Chakraborty Priyanka , Sarkar Anirban
Published: July 2022

The building of a re-configurable business process (BP) has gained importance in business organizations. It helps the organization to adapt to the agility in business goals. A proper context-driven re-configurable BP should be capable of integrating dynamic context information. However, this is absent in the existing studies. As a result, providing a suitable, expressive and re-configurable BP to the business organization stakeholders has become a challenging issue. The prevailing research works lack the proper consideration and suitable incorporation of the context-driven services to make a BP re-configurable. And then it can quickly respond and change its behavior to adapt to the rapid and unpredictable changing business environment. In addition, those methods hardly come up with any appropriate technique to use the set of specified goals to extract context-driven services. Those business goals are determined by the group of stakeholders of a business organization. This paper proposes a new method of re-configuring context-driven from a defined goal to sort out these vital challenges. Present context data is included in an existing BP to achieve a modified goal which immensely benefits the end-users. Thus, this approach is intrinsically highly user-centric, reusable, fast and inexpensive. To achieve this, an algorithm called Context-driven Re-configurable Business Process Achievement Algorithm (CDRBPA) is introduced and implemented. Based on Primary Context (PC), three software metrics, namely, Degree of re-usability (DRUPC), Degree of re-appropriation (DRAPC) and Degree of re-configurability (DRPC) have been proposed to measure the modifications done to the existing BP. In conclusion, various case studies with different complexities have been performed to show the strength of the proposed algorithm.
RHOA-regulated IGFBP2 promotes invasion and drives progression of BCR-ABL1 chronic myeloid leukemia
Authors: Zhang Hualei , Cai Baohuan , Liu Yun , Chong Yating , Matsunaga Atsuko , Mori Stephanie Fay , Fang Xuexiu , Kitamura Eiko , Chang Chang-Sheng , Wang Ping , Cowell John K , Hu Tianxiang
Published: July 2022

The Philadelphia 9;22 chromosome translocation has two common isoforms that are preferentially associated with distinct subtypes of leukemia. The p210 variant is the hallmark of chronic myeloid leukemia (CML) whereas p190 is frequently associated with B-cell acute lymphoblastic leukemia. The only sequence difference between the two isoforms is the guanidine exchange factor domain. This guanidine exchange factor is reported to activate RHO family GTPases in response to diverse extracellular stimuli. It is not clear whether and, if so, how RHOA contributes to progression of p210 CML. Here we show that knockout of RHOA in the K562 and KU812, p210-expressing cell lines leads to suppression of leukemogenesis in animal models in vivo. RNA-sequencing analysis of the mock control and null cells demonstrated a distinct change in the gene expression profile as a result of RHOA deletion, with significant downregulation of genes involved in cell activation and cell adhesion. Cellular analysis revealed that RHOA knockout leads to impaired cell adhesion and migration and, most importantly, the homing ability of leukemia cells to the bone marrow, which may be responsible for the attenuated leukemia progression. We also identified IGFBP2 as an important downstream target of RHOA. Further mechanistic investigation showed that RHOA activation leads to relocation of the serum response factor (SRF) into the nucleus, where it directly activates IGFBP2. Knockout of IGFBP2 in CML cells suppressed cell adhesion/invasion, as well as leukemogenesis in vivo. This elevated IGFBP2 expression was confirmed in primary CML samples. Thus, we demonstrate one mechanism whereby the RHOA-SRF-IGFBP2 signaling axis contributes to the development of leukemia in cells expressing the p210 BCR-ABL1 fusion kinase.
Factores que inciden de la comunicación asertiva en el desarrollo organizativo del turismo comunitario del mirador Tzunantza, Ambato, Ecuador
Authors: Caiza Tisalema Segundo Ángel , Cañizares Medina Andrés Ernesto , Herrera Hugo Blanca de los Ángele
Published: July 2022

La comunicación asertiva es una característica que se encuentra en los seres humanos y se cataloga como una habilidad social que se utiliza para aplicarla en el ámbito empresarial para que la organización sea competitiva, ya que el mensaje que origina será claro para los usuarios. receptores, en el caso del turismo comunitario, esta comunicación asertiva juega un papel preponderante aún más porque repercute en la calidad de vida de sus habitantes, por ser una actividad económica para la comunidad, en este estudio se pretende contextualizar los factores de la comunicación asertiva que se puede utilizar como estrategia para promover el turismo comunitario, los hallazgos de esta investigación muestran que existen dos factores más relevantes sobre el tema, el primero es la actitud de los líderes comunitarios en la comunicación hacia las personas para que integrar y lograr los objetivos comunitarios en materia de turismo y el segundo factor es la capacitación organizativa, la cual debe ser constante, pues es una forma adecuada de comunicación asertiva para que los planes o programas se puedan llevar a cabo integralmente en la comunidad.
El método comunicativo para la innovación en la enseñanza de la destreza oral, en inglés como lengua extranjera
Authors: Mantilla Cabrera Luis Francisco , Carrillo Rodríguez Mayra Alexandra , Guambo Yerovi Enrique Jesús , Rivadeneira Mora Jimena Elizabeth
Published: July 2022

Introducción. Esta investigación presenta la correlación de las variables Método Comunicativo        y el proceso enseñanza - aprendizaje de la habilidad de hablar inglés. Esta propuesta se aplicó a los estudiantes de la Carrera de Mantenimiento de la ESPOCH. Objetivo. Se determinó el nivel de influencia de las técnicas basadas en el Método Comunicativo en la mejora de la destreza oral. Metodología. Se utilizaron dos métodos, técnicas e instrumentos para la intervención. Mediante su aplicación fue posible obtener datos con un alto grado de exactitud y confiabilidad. Un análisis estadístico descriptivo e inferencial mostró una mejora significativa en la habilidad para hablar en inglés en la comparación entre el pre y el post test. Para esta prueba se utilizó una prueba y rubrica de Cambridge nivel B1, para determinar la mejora cualitativa se utilizó una guía de observación. Resultado. El instrumento test evidenció una mejora de 2.3 puntos en la destreza oral. Al aplicar la prueba T-student con los datos obtenidos se ratificó el cambio luego de la aplicación del proyecto. La guía de observación mostró la correlación bilateral entre las variables. Todos los resultados demostraron el impacto positivo del Método Comunicativo en la destreza oral en inglés. Conclusión Se concluyó que el proyecto aporta significativamente en la enseñanza del idioma inglés y específicamente mejora la destreza oral. Se recomienda continuar investigando sobre este método para generar nuevos conocimientos para la enseñanza de lenguas extranjeras.
ЕКСПЕРТНА СИСТЕМА АНАЛІЗУ АВАРІЙ СУДНОВОЇ КОТЕЛЬНОЇ УСТАНОВКИ
Authors: Штрибець Валерій Валерійович , Трофименко Анастасія Олегівна , Тришин В’ячеслав Валентинович , Ліганенко Віталій Валерійович
Published: July 2022

Функціонування суднової котельної установки пов'язано з великою кількістю потенційних відмов, які, у свою чергу, викликають аварії і можуть призводити як до людських жертв, так і до пошкодження суднового устаткування. У роботі узагальнені дані про аварії суднових котельних установок (вибухи, пожежі, відключення електроенергії або інші серйозні порушення у роботі морських суден) з метою визначення найгірших сценаріїв під час їх роботи. Для кількісного аналізу ризиків виникнення аварій суднової котельної установки вдосконалений підхід з використанням нечіткої експертної системи на основі використання у відповідних продукційних правилах інтервальних нечітких множин другого типу. При цьому в якості функцій приналежності вдосконаленої нечіткої експертної системи використовуються площі невизначеності інтервальних нечітких множин другого типу.
Інтервальні нечіткі множини другого типу, з одного боку, забезпечують формалізацію більшої кількості додаткових ступенів невизначеності в порівнянні з класичними нечіткими множинами першого типу, з іншого боку, є такими, що реалізуються при розробці нечітких логічних систем і мають меншу обчислювальну складність, у порівнянні з нечіткими множинами другого типу.
Під час дослідження були протестовані три типи функцій приналежності для створення нечітких множин і виділення відмінностей між цими функціями (функція приналежності Гауса (GMF), трикутна функція приналежності (TMF) і функція приналежності трапецієподібної форми (ZMF)).
В якості базової методології аналізу аварій у роботі використання підхід метод аналізу ризиків, він розглядає проблеми, пов'язані з характеристиками системи і режимами відмови для кожного компонента системи, та забезпечує наявність відповідних заходів безпеки, що в свою чергу підходить для визначення, ідентифікації і перевірки механічних та електричних апаратних систем на предмет потенційних відмов (Failure Mode and Effects Analysis (FMEA)).
Ключові слова: суднова котельна установка, аварійна ситуація, інтервальна нечітка множина другого типу, площа невизначеності.
Students’ Responses to Teacher’s Reinforcement: A Discourse Analysis
Authors: Meizy Pemilda Alphania , Suharjito Bambang , Rofiq Annur
Published: July 2022

Reinforcement is one of the important aspects in increasing students' motivation, to be more serious, and more focused during the teaching-learning process. This research is intended to know the kinds of reinforcement used by the teacher, how students respond to it, and how was their feeling about it. The design of this research is Discourse Analysis that focuses on the semiotic area. This research was conducted at one of the state junior high schools in East Java, Indonesia. The participant was chosen by using purposive sampling method and class 7F students were selected as the research participants. In conducting the research, the researcher did classroom observation, took video recording, and did an interview with the students to know exactly the meaning of students' responses. The finding showed that the teacher used verbal and non-verbal reinforcement. Mostly, the teacher praised the students for what they have done and students mostly showed their response using facial expression and sometimes using body gesture. Regarding their feeling, they said that reinforcement from the teacher makes them feel appreciated, motivated and happy during the teaching-learning process, which means that the role of reinforcement is very important.
Incidência das infecções sexualmente transmissíveis em adolescentes com idade entre 13 e 19 anos residentes no município de Cascavel entre os anos de 2010 e 2020
Authors: Paltanin Sinara Vidotti , Lima Urielly Tayná da Silva
Published: July 2022

As ISTs (Infecções Sexualmente Transmissíveis) têm se destacado como agentes em ascensão na disseminação de doenças sexualmente transmissíveis entre adolescentes. Assim, o presente estudo tem por objetivo realizar por amostragem o número de adolescentes com idade entre 13 a 19 anos residentes na cidade de Cascavel entre os anos de 2010 a 2020 que apresentaram, durante o período em análise, alguma infecção sexualmente transmissível e procuraram tratamento e orientação médica em alguma unidade de saúde. Para isto, foi empregada uma metodologia de cunho quantitativo, do tipo descritivo, analisando os dados obtidos e os apresentando em gráficos de forma explicativa e descritiva. A pesquisa apontou como principais resultados que 67,71% dos pacientes que apresentaram alguma IST é do gênero masculino; 50% se apresentaram de cor branca; da população jovem entre 10 e 19 anos que apresentaram diagnóstico positivo para alguma IST 96,34% tem idade entre 15 e 19 anos;6% da população total que apresentou diagnostico positivo para alguma IST, tem idade entre 10 e 19 anos. Com a obtenção de dados reais presente na população de adolescentes da cidade de Cascavel, as entidades governamentais e seus respectivos setores educacionais e de saúde poderão trabalhar em conjunto, norteados e fundamentando subsídios que estruturarão e direcionarão ações eficientes para o controle e extermínio das ISTs no município.
Frequência de anticorpos anti-Toxoplasma gondii em patos abatidos no município de Belém, Pará, Brasil
Authors: Nunes Gabriel de Lima , Morais Rafaela dos Anjos Pinheiro Bogoevich , Carmo Ediclei Lima do , Simões Marcelo Coelho , Costa Wanda Silva , Marinho Rodrigo Rodrigues , Bichara Clea Nazaré Carneiro
Published: July 2022

A infecção causada pelo Toxoplasma gondii é uma importante zoonose de ampla distribuição mundial. No estado do Pará o consumo de aves é alto, em especial os frangos. Outro grupo de aves, os patos (Cairina moschata), também tem relevância na culinária local, restrita a determinados períodos do ano. Este estudo objetivou determinar a frequência da infecção pelo T. gondii em patos domésticos encaminhados para abate no município de Belém- PA. Foram avaliados 172 patos, de ambos os sexos, procedentes de três municípios produtores desses animais (Castanhal, Santa Izabel do Pará e Capitão Poço), submetidos a sistemas de criação semi-intensiva ou extensiva. Amostras de soro dessas aves foram analisadas pelo método de hemaglutinação indireta (HAI) qualitativa e semiquantitativa para anticorpos anti-T. gondii, utilizando como ponto de corte a diluição de 1:16. A frequência obtida de anticorpos anti-T. gondii foi de 16,28% (28/172). Não houve diferença estatística quanto ao sexo das aves, no entanto, houve diferença entre os três municípios e os sistemas as quais as aves foram criadas, sendo presente e maior o risco de infecção em Santa Izabel do Pará de modo semi-intensivo e em Capitão Poço extensivamente. Este foi o primeiro registro da frequência de toxoplasmose em patos no estado, apesar de estar abaixo dos padrões regionais demonstra o risco do consumo da carne desses animais como fonte de infecção para toxoplasmose em humanos e outros animais, além de indicar a contaminação do ambiente criadouro, com oocistos de T. gondii, principalmente em Santa Izabel do Pará e Capitão Poço.
Avaliação microscópica da articulação manubrioesternal
Authors: Ferreira Sabrina Marques , Souza Ana Cristina Romano Marquez
Published: July 2022

Introdução: A classificação anatômica, histológica e funcional da articulação manubrioesternal é um assunto que tem causado divergência entre os autores. É considerada uma articulação cartilagínea secundária (sínfise), em que a união óssea acontece através de fibrocartilagem, e tem sido classificada como cartilagínea primária (sincondrose), em que a união óssea acontece através de cartilagem hialina. Objetivo do projeto consiste na avaliação macroscópica e microscópica da articulação manubrioesternal em esternos previamente dissecados pertencentes ao laboratório de anatomia da Universidade de Uberaba visando identificar os tecidos que compõem a união óssea, classificá-las e comparar com o que já foi descrito na bibliografia. Metodologia: foram selecionados fragmentos de 6 articulações manúbrioesternais de peças anatômicas e confeccionadas lâminas desses fragmentos, que foram coradas com hematoxilina e eosina, picrosiriushematoxilina e tricrômico de gomori. Posteriormente, as lâminas foram analisadas em microscópio óptico visando identificar o tecido responsável pela união óssea. Resultado: Após a análise lâminas confeccionadas, verificamos que todas as uniões ósseas aconteciam por meio de cartilagem fibrosa e, portanto, todas foram consideradas cartilagíneas secundárias (sínfise). Conclusão: Apesar da divergência na literatura, concluímos que, a articulação manubrioesternal é classificada como sínfise.
Empoderamento feminino na agricultura familiar no estado da Bahia, Brasil
Authors: Bruno Nelma Lima , Profice Christiana Cabicieri , Aguiar Paulo César Bahia de , Pires Mônica de Moura , Ferraz Marcelo Inácio Ferreira
Published: July 2022

Este artigo tem como principal objetivo analisar o empoderamento feminino na agricultura familiar nos Projetos de Assentamento Rural Nova Vida e Limoeiro, estado da Bahia, Brasil. Como método norteador da pesquisa utilizou-se a ferramenta para medir o Índice de Empoderamento das Mulheres na Agricultura (WEAI) adaptada numa perspectiva de aplicação e análise de gênero em assentamentos rurais de reforma agrária. Neste estudo, utilizou-se das respostas dadas especialmente por mulheres sobre os membros de suas famílias, e sobre as suas realidades em relação à comunidade, a partir de um formulário semiestruturado, o qual no Nova Vida foi aplicado no ano de 2020, e no Limoeiro no ano de 2021, ambos presencialmente. O formulário semiestruturado continha os indicadores em cinco domínios de empoderamento feminino: produção, recursos, renda, liderança e tempo. A escala adotada foi a de 0 a 4, com cinco faixas de empoderamento, da pior situação para a mais satisfatória. Os subíndices e o índice geral de empoderamento correspondem à média ponderada simples das pontuações obtidas respectivamente pelos indicadores e pelos cinco domínios. Os resultados indicaram que na comunidade do assentamento Nova Vida, de forma geral, as mulheres se encontravam em situação de baixo-médio empoderamento na agricultura, e na comunidade do assentamento Limoeiro essa situação era de médio empoderamento. Nos dois assentamentos, os indicadores “decisões sobre planejamento e gestão do lote” e “tempo” da rotina diária, evidenciaram que o gênero feminino pouco participava das decisões relativas à produção e que tinham uma sobrecarga em horas somando atividades domésticas e agrícolas. Isso pode estar contribuindo para um menor empoderamento desse gênero, algo que poderia ser amenizado com a maior distribuição das tarefas domésticas destas com companheiros e filhos.
The impact of urbanization and domestic waste on a small watercourse in the eastern Amazon basin
Authors: Saviato Mário Junior , Guimarães Júnior José Carlos , Lima Jucivaldo Dias
Published: July 2022

The present study shows the physical and chemical parameters collected in an urban river in the Eastern Amazon, they present the characteristics of the waters in the Neblina stream, which has its basin inserted in an urban center, in the city of Araguaína - TO. Therefore, the present study aims to investigate the water quality parameters of that stream, and thus allow deductions about the causes and effects of these changes. In this stream, sampling points were listed that contemplate environments from the springs to its mouth. Being, the quality of its waters, evaluated in two stages that envision two seasons (dry and rainy), respectively, August 2020 and March 2021. Adding a total of six sampling points, systematically visited in both seasons described, making up 12 samples, for all parameters analyzed here. In this way, the samples were explored in order to find values for the parameters: In Situ (Turbidity by turbidimeter; Dissolved oxygen; Electrical conductivity; Water temperature; Air temperature; pH); and Ex Situ (BOD; COD; Nitrogen series; Phosphate series; Fecal coliforms; Chlorophyll-α; Heavy metals). The parameters showed similar variations between the sampling points, with a notable data discrepancy between the mouth and head of the Neblina stream. These results show that there are higher concentrations for these parameters, directly related to the length of the route in the urban environment. Indicating a possible impact on the existing fauna and flora, which may conjecture a plausible toxicity and risks to organisms, as an admissible threat to biodiversity.
As implicações psicológicas da violência nas relações íntimas homoafetivas entre homens
Authors: Gomes Maxwell Lopes
Published: July 2022

A temática que se debruça sobre a existência da violência nas relações intimas homoafetivas entre homens é uma vertente pouco explorada e marginalizada, diante disto se faz primordial e importante o estudo acerca desta, assim, tem-se como proposta e objetivo geral desta pesquisa: analisar quais são as implicações psicológicas advindas da violência nas relações íntimas homoafetivas entre homens. Para tal análise foi realizada uma revisão integrativa da literatura, formulada em seis passos metodológicos, onde foram definidos através de critérios de inclusão e exclusão 12 artigos sobre a temática. A pesquisa foi realizada no mês de junho de 2022, através das bases de dados que seguem: Literatura Latino Americana Caribe em Ciências e Saúde (LILACS), Medical Literature Analysis and Retrievel Sistem Oline (MEDLINE) por meio da Biblioteca Virtual em Saúde (BVS); Scientific Electronic Library Online (SciELO), Periódicos Eletrônicos em psicologia (PEPSIC) e o Google Scholar. Os principais resultados encontrados se dão ao tocante de que homens sob o contexto de violência na intimidade são passíveis ao desencadeamento de alterações psicológicas negativas, podendo serem perpetuadas através da somatização à esfera física, desta forma tornando-se um problema de saúde pública passível de intervenção e olhar crítico social.