bluuebunny/crossref_metadata_2025 huggingface dataset:
Shear Behaviour of RC Beams: A Numerical Study
Authors: SÖĞÜT Kağan
Published: August 2023

A two-dimensional (2D) nonlinear finite element (FE) model created for reinforced concrete (RC) beams is presented in this paper. The FE model was verified in order to perform further parametric studies on RC beams with and without existing steel shear links. The parameters were tension reinforcement ratio, concrete compression strength, and beam size. Moreover, the accuracy of “Turkish Standards 500: Requirements for design and construction of reinforced concrete structures (TS500)” in terms of predicting the total shear force capacity of RC beams was examined. The FE model properly captured the experimental load capacity, with a mean value of 1.04. The increase in overall shear force capacity caused by the increasing tension reinforcement ratio from 1.79 to 3.33% was 18.3% for RC beams with existing steel shear links, whereas it was 10.6% for RC beams without existing steel shear links. The total shear force capacities of RC beams with and without steel shear links increased once concrete compression was increased from 30 to 70 MPa. An increasing beam size resulted in a reduction in shear stress at failure of 33.8% and 32.7% for RC beams with and without shear links, respectively. TS500 design code gave conservative results in calculating the overall shear force capacity of RC beams.
Arendt in the Platformised World: Labour, Work and Action on Digital Platforms
Authors:   , Charlton-Czaplicki Timothy
Published: August 2023

Platformisation—how institutions, organisations and cultural practices are reorganised on and through digital platforms—is a central area of research in the social sciences. The platformisation of work in particular receives scrutiny in academia and mainstream media. However, existing theories about a platformised future of work have focused predominantly on economic factors and leave a blind spot about how a transformation of our basic activities affects political life, i.e. our capacity for pluralistic interaction. This dissertation draws on Arendt’s political theory to investigate this connection by mapping the impact of platformisation on human activity—labour, work and action—using an abductive research process composed of three empirical analyses: a sequence analysis of gig workers’ careers, a topic model of remote gig workers’ discourse and a qualitative content analysis of open source intelligence and investigation communities. Interest in Arendtian political theory is cyclically resurgent and her ideas are regularly invoked to flag totalitarian developments in politics, law and technology. Yet, nowhere does Arendt formalise a theory to evaluate emergent phenomena. This dissertation engages with Arendt’s writings and sources to construct a suitable analytical framework. By linking Arendt’s ontology of activity with the qualities of the public realm, it becomes possible to trace how changes to the configuration of labour and work through platformisation can destabilise the worldly foundations of our political interaction. Arendt’s central message is that the way we work and our capacity for political action are intimately connected. Work is not itself political, but it creates the necessary conditions for individuals to withdraw from their private lives into the public and openly engage in deliberative politics. Understood from an Arendtian perspective, the question about the future of work on platforms is always also a political question. The findings suggest that platformisation both inhibits and enables political life by undermining the quality of the work process and allowing for new platform-enabled forms of hybrid work-action to be performed. Using the ‘factory’ and the ‘polis’ as leading images, this dissertation unpacks the duality of platformisation to define a set of recommendations for platform design and governance. It continues a tradition of applying social theory in Information Systems research by introducing an underutilised philosophical perspective to the scholarly discourse on platformisation. It further contributes to Arendt scholarship by developing a normative perspective on technology based on the vita activa and demonstrating how it can be used to analyse contemporary technologies 65 years after it was first published.
Macroinvertebrates Community Annual Dynamics in Taitema Lake after ecological water transport
Authors: Zou Hongguang , Wang Shuping , Wu Jiaxin , Kong Weijing , Liu Xueyu
Published: August 2023

In lakes, analyses of community structure and relationships of
macroinvertebrates with environmental factors are often used to judge
the status of watershed ecosystems and for scientific ecological
management. However, this method has been less applied to lakes in arid
regions. Here, a seasonal ecological survey was conducted in Lake
Taitema (including the Tarim River, the Chelchen River, Lake Taitema,
and Lake Kanlak) during 2021-2022 to explore the spatial and temporal
patterns of macroinvertebrates communities in the basin and their
relationships with environmental factors. The aim is to provide a
scientific basis for the subsequent ecological health management of Lake
Taitema and relevant content for the study of macroinvertebrates
communities in arid lakes. This survey, 552 macroinvertebrates were
collected and identified, belonging to 17 species of 13 families in 2
phyla, 3 orders, and 6 classes. The community composition, diversity,
and dominant species changed seasonally, but no apparent spatial
distribution differences between rivers and lakes existed. The
correlation between environmental factors and the macroinvertebrates
community showed different effects each season. DCA analysis revealed
that the main environmental impact factors in winter were chloride ions
(Cl-); in spring, were Cr and salinity (SAL); in summer, was pH. The
main dominant species were more dominant to the overall community in
Lake Taitema.
Systemic IL-26 correlates with improved asthma control in children sensitized to dog allergen
Authors: Kovach Melissa A. , Käck Ulrika , F Karlhans Che , Brundin Bettina , Konradsen Jon R. , Lindén Anders
Published: August 2023

Background: Interleukin (IL)-26 is produced by T helper type 17
(Type 17) cells and exerts immunomodulatory plus antimicrobial effects.
Previous studies show that local IL-26 concentrations in the airways are
higher in patients with uncontrolled than in those with controlled
asthma, and that this intriguing cytokine bears biomarker potential.
Here, we determined how systemic IL-26 relates to allergen
sensitization, asthma severity, and to IL-17A in children.
Methods: Serum samples were obtained from children with (n=60)
and without (n=17) sensitization to dog allergen, and IL-26 and IL-17A
protein concentrations were measured using ELISA. Self-reported history,
including medication use and validated symptom-based questionnaire
scores, was recorded. Results: The serum concentrations of
IL-26 were enhanced in allergen-sensitized subjects and correlated with
those of IL-17A in a positive manner. However, the IL-26 concentrations
did not markedly differ between allergen-sensitized subjects with and
without asthma, eczema, allergic rhinitis, or a history of food allergy.
Notably, IL-26 concentrations correlated with increasing Asthma Control
Test (ACT) scores in a positive manner and with inhaled corticosteroid
in a negative manner, amongst sensitized subjects with asthma. Moreover,
subjects with asthma requiring ≥1 course of oral corticosteroids in the
preceding 12 months had decreased IL-26 concentrations.
Conclusion: This study forwards evidence that systemic IL-26,
just like IL-17A, is involved in allergen sensitization among children.
The association of systemic IL-26 with improved asthma control is
compatible with the cellular sources being recruited into the airways in
severe asthma, which supports that this kinocidin bears potential as a
biomarker and therapeutic target.
PDGFRβ-antagonistic affibody mediated tumor-targeted TNFα for enhanced radiotherapy in lung cancer
Authors: Tang Xiaohui , Chen Jie , Zhao Zhenxiong , Liu Jie , Yu Ranfei , Zhao Kunlong , Wang Fei , Li Yang , Tian Baoqing , Yuan Dandan , Wei Qin , Liu Yuguo , Gao Zhong Feng , Fan Qing
Published: August 2023

The morbidity and mortality of lung cancer are still the highest among
all malignant tumors. Radiotherapy plays an important role in clinical
treatment of lung cancer. But the effect of radiotherapy is not ideal
due to the radiation resistance of tumor tissues. Abnormalities in tumor
vascular structure and function affect blood perfusion and oxygen
transport is impeded, making tumor microenvironment hypoxic. Tumor
hypoxia is the major cause of radiotherapy resistance. By promoting
tumor vessels normalization and enhancing vascular transport function,
tumor hypoxia can be relieved to reduce radiotherapy resistance and
increase tumor radiotherapy sensitivity. In our previous study, a
pericytes-targeted tumor necrosis factor alpha (named Z-TNFα) was
firstly constructed and produced by genetically fusing the
platelet-derived growth factor receptor β (PDGFRβ)-antagonistic affibody
(ZPDGFRβ) to the TNFα, and the Z-TNFα induced normalization of tumor
vessels and improved the delivery of doxorubicin, enhancing tumor
chemotherapy. In this study, the tumor vessel normalization effect of
Z-TNFα in lung cancer was further clarified. Moreover, the tumor hypoxia
improvement and radiosensitizing effect of Z-TNFα were emphatically
explored in vivo. Inspiring, Z-TNFα specifically accumulated in Lewis
lung carcinoma tumor graft, and relieved tumor hypoxia as well as
inhibited HIF-1α expression. As expected, Z-TNFα significantly increased
the effect of radiotherapy in mice bearing Lewis lung carcinoma tumor
graft. In conclusion, these results demonstrated that Z-TNFα is also a
promising radiosensitizer for lung cancer radiotherapy.
PAH-D, is there a non-invasive way to predict the unpredictable?
Authors: Abdelmassih Antoine , Karaghouli Yusur Ibraheem Al , Ali Alya Al
Published: August 2023

Group D PAH-CHD is a problematic increasingly recognized group of
patients, in which pulmonary hypertension continues to progress despite
the correction of a significant cardiac lesion with pulmonary overflow.
Early and non-invasive testing that can predict this subset of patients,
prior to correction of their underlying cardiac lesion, is still
non-established in practice and under-investigated in literature. Serum
markers and angiogenic molecules denoting apoptosis resistance, can be
game changer to the standard practice in this context. We hope that this
letter can encourage researchers concerned with PAH-CHD to start
investigating the diagnostic accuracy and cut-off values of these
biomarkers.
CNTFET based Single Ended Fractional Order Colpitts Oscillator: Design, Simulation and Comparative Analysis
Authors: Loan Sajad , Bhatt Ankita
Published: August 2023

In this paper, we design and simulate single ended Colpitts
Oscillator (CO) in integer and fractional order domains. The oscillators
are realized in 32 nm node conventional MOSFET and carbon nanotube field
effect transistors (CNTFET) technologies. Therefore, four COs have been
designed, simulated and rigorously compared. These include integer order
conventional MOSFET based CO, fractional order MOSFET based CO, CNTFET
based integer order CO and CNTFET based fractional order CO, all based
on 32 nm technology nodes. The fractional order approach has been used
as it results in better control over the phase and frequency of the
oscillator. Herein fractional order capacitors of various orders, used
in realizing the fractional order COs, are realized and their frequency
responses are studied. This is being done to ensure whether the designed
pseudo-capacitances have fractional behavior or not in the desired
frequency and phase spectrum. It has been observed that the variation of
fractional order (α) from 0.4 to 0.81 has resulted in a slight reduction
of oscillation frequency from 1.68GHz (α=0.4) to 1.351GHz (α=0.81)
keeping the pseudo-capacitance same at 0.3nF in MOS based topology.
Further, CNTFET based integer order as well as fractional order COs have
been designed to address the power consumption and the complexity issues
of the fractional order COs. The CNTFET based fractional order CO
retains the advantages of fractional order domain as well as power
efficiency of CNTFETs. Furthermore, it has been observed that
integrating fractional order capacitor (FOC) with the CNTFET CO results
in much larger constant phase zone (CPZ), an important performance
measuring parameter. A rigorous comparative analysis of the four COs
designed in this work has been performed.
Long non-coding RNA GAS5 rs145204276 indel polymorphism and cancer risk: A systemic and meta-analysis review
Authors: Poursheikhani Arash , Askari Vahid Reza , Taghizadeh Eskandar , Nokhandani Negin , Salmaninejad Arash , Ferns Gordon A , Pasdar Alireza , Ghayour-Mobarhan Majid
Published: August 2023

Introduction: Cancer is the second most common cause of death globally.
It has been demonstrated that long non-coding RNAs (lncRNAs) may play an
essential role in cancer development. The lncRNA growth arrest-special 5
(GAS5) is a critical tumor suppressor in many types of human cancers. We
have therefore conducted a meta-analysis to determine the association of
lncRNA GAS5 rs145204276 indel polymorphism and cancer risk. Methods: A
comprehensive literature search in PubMed, Scopus, and Web of Knowledge
were conducted up to July 1, 2019. Eligible studies were included in a
meta-analysis. All statistical analyses were conducted using the
Metagenyo online tool. Results: Our results showed no significant
association between the lncRNA GAS5 rs145204276 and cancer risk using
all genetic models. In subgroup analysis, the polymorphism demonstrated
a significant association with a lower risk of gastric cancer.
Sensitivity analysis confirmed the robustness of our results. No
publication bias was also identified. Conclusions: Although the lncRNA
GAS5 polymorphism is not associated with increased cancer risk, but its
polymorphism was associated with a reduced risk of gastric cancer in
subgroup analysis. Further studies with larger sample sizes across
different ethnicities need to be performed to explore the association’s
strength.
Transient analysis of growth/decay in materials utilizing a digital exponential peeling method
Authors: Mukherjee Jayjit , Malik Amit , Vinayak Seema , Kumar Vikram , Rawal D. S. , Dhaka R. S.
Published: August 2023

An algorithm is proposed to implement digital peeling to determine
dominant time constants of an exponential transient process. The method
is simpler to implement and reduces computational time to a large extent
in comparison to other techniques widely used. Apart from a synthetic
test function, the algorithm has been implemented on reported
experimental transient decay curves of Cs HfCl
(CHC) single crystal scintillation to verify its
efficacy. Finally, drain current detrapping transients of unpassivated
AlGaN/GaN high electron mobility transistors (HEMTs) are analysed to
determine the trap energy levels and concentrations. The validation of
this digital peeling technique is also carried out by comparing with
conventional method of time constant extraction from HEMT current
transients. The extracted exponentials from the transient data
efficiently fits well with the experimental data and can be extensively
used for transient analysis. The digital peeling technique has wide
applicability and can be used to analyze all exponential processes which
occur in all domains of science.
Total Saponins from Panax Japonicus Promote Lipolysis of Aging Fat Through the Tyrosine Hydroxylase Signaling Pathway
Authors: Yuan Chengfu , Xue Mengzhen , Wu Wei , Zhao Jiale , Zhu Leiqi , Wang Yaqi , Xia Fangqi , Li Yuanyang , Zhang Yifan , Hu Yaqi , Wang Shuwen , Wang Rui , Yuan Qi , Gui Yibei , Li Xueqing , Wang Lijun , Wang Hailin , Luo Yiyang , Yuan Ding , Yumin * , Ding Xueliang
Published: August 2023

Aging and obesity are closely related, and the prevalence of obesity and
metabolic diseases are rapidly increasing with an aging population
worldwide. A key change in the adipose tissue during the aging process
is the decline of lipolysis, and the excitation of the sympathetic nerve
system is a key pathway to promote lipolysis. Previous studies have
shown that the total saponins from Panax japonicus (TSPJs) can
prevent obesity in mice with high-fat diet by increasing fat
decomposition. In this work, we examine the regulatory effects of TSPJs
on lipolysis in the aging state and explore the possible mechanisms.
TSPJs can promote the excitation of sympathetic nerves by increasing the
expression of tyrosine hydroxylase in the adipose tissue, which
positively regulates the expression of lipases to revitalize lipolysis.
The results suggest that TSPJs can help to resist aging-induced obesity
and may be a potential medication for weight management.
Antimicrobial peptide expression and gastric bacteria associated with Helicobacter pylori infection in patients with gastritis
Authors: An Wen , Wang Sui , Wang Jue-Xin , Huang Gang , Tian Lin , Li Jia-Yi , Yu Yan-Bo , Li Yan-Qing
Published: August 2023

Background: The complex interplay between the continuous infection of
Helicobacter pylori (Hp) in gastric mucosa and the development of
Hp–associated gastritis remains poorly understood. The interaction
between the gastric epithelium and the immune response induced by Hp may
be an important contributing factor. Antimicrobial peptides (AMPs) can
protect the gastric mucosa from bacteria. This study aimed to
investigate the effects of Hp on the gastric flora, AMP (e.g., REG3A,
HBD2 and S100A9) expression and the mucosal ultrastructure in
Hp-positive (Hp+) patients with gastritis. Methods: The bacterial
composition was analyzed in 63 patients with gastritis using 16S rRNA
sequencing. The altered expression levels of AMPs (REG3A, HBD2 and
S100A9) were analyzed by RT-qPCR for quantification of AMP mRNA levels.
Western blotting and immunohistochemical staining were used to
investigate AMPs expressions in the gastric biopsies. Observation of the
gastric ultrastructure was performed by transmission electron microscopy
(TEM). Results: HP infection significantly reduced the abundance of
bacteria. REG3A, S100A9, and HBD2 were highly expressed in Hp+ patients.
The destruction of the epithelial cell membrane and the entry of mucus
particles into the gastric lumen were observed by TEM in Hp+ patients.
Conclusion: The findings reported here confirm the dysbiosis of gastric
microecology and AMPs expression in gastritis patients infected with Hp.
This study provides information on the complex and dynamic ecosystem and
may be helpful for further research to find a treatment alternative in
the post‐antibiotic era to eradicate multidrug‐resistant Hp strains.
Association between sleep during pregnancy and birth outcomes: A prospective cohort study
Authors: Chen Huanjun , Lv Chuanzhu , Yan Shijiao , Zhang Caihong , Hao Wenjie , Lai Yuwei , Sun Zhonghan , Lu Qian , Wang Rixing , Pan Xiong-Fei , Song Xingyue
Published: August 2023

Objective: A prospective cohort study was conducted to
investigate sleep status during the first and second trimester of
pregnancy in pregnant women on adverse birth outcome, such as preterm
birth (PTB), low birth weight (LBW) and small for gestational age (SGA).
Design: Prospective cohort study. Setting: China.
Population: Cases were singleton pregnant women aged 18-40
years from the prospective Tongji-Shuangliu Birth Cohort.
Methods: Multivariable logistic regression models were used to
analyze the associationof sleep status during the first and second
trimester of pregnancy with adverse birth outcomes and generated the
odds ratio (OR) and 95% confidence interval (CI). Main outcome
measures: Birth outcomes. Results: Finally, 5,412 pregnant
women were included in the analysis. In the multivariable model,
compared with 8-9 hours/night, sleep less than 7 hours/night during
second trimester increases the risk of PTB (OR: 1.80, 95% CI:
1.12,2.89), and the risk of PTB was decreased in pregnant women who
slept ≥11 hours/night (OR: 0.53, 95% CI: 0.30,0.93). Sleep quality,
napping and sleep changes in the first and second trimesters, and sleep
duration in the first trimester were not statistically associated with
PTB, LBW and SGA. Conclusions: Short sleep duration during
pregnancy is associated with a higher risk of PTB, while longer sleep
duration at night is associated with a lower risk of PTB. Sleep status
during pregnancy was not associated with LBW and SGA. In order to reduce
risk of adverse birth outcomes, sleep problems in pregnant women should
be strengthened during pregnancy care.
Peripheral neuromodulation: Type 2 Complex Regional Pain Syndrome secondary to an excisional biopsy
Authors: Gouveia João , Caldeira Marta , Correia Duarte
Published: August 2023

Background: Complex Regional Pain Syndrome (CRPS) is a multifactorial
and often refractory condition that involves hyperalgesia and allodynia
of the extremities. Current treatments are mostly limited and
short-lived, thus different modalities of interventional pain control,
have come up to play a significant role in the management of CRPS.
Objectives: The aim of this article is to present a single case from a
Multidisciplinary Pain Management Center, regarding a wireless
peripheral nerve stimulation (WPNS) treatment for a type II CRPS.
Methods: The EORTC QLQ-C30 and NHP questionnaires were used as tools,
during an eighteenth month period follow-up. Results: A 43-year-old
healthy woman, diagnosed with ganglionar tuberculosis and a refractory
type II CRPS in the right upper extremity, following an excisional
biopsy. She underwent placement of a permanent electrode in the right
ulnar nerve. During eighteen months, a progressive reduction of pain
medication was also achieved and an improvement in her quality of life
associated to a remarkable relief in pain, allodynia and temperature
impairment. Conclusions: Given its high acceptance, safety and potential
to influence the neuronal plasticity, WPNS thus shows to be a promising
and favorable tool in the multidisciplinary approach of CRPS.
Analysis of risk factors for postoperative recurrence or progression of intravenous leiomyomatosis: A retrospective study
Authors: Zhang Guorui , Yu Xin , LANG Jinghe , LIU Bao , ZHAO Dachun
Published: August 2023

Objective: Intravenous leiomyomatosis (IVL) features
histologically benign smooth muscle tumors growing within blood vessels.
Although surgery is the primary treatment method, the rate of
postoperative recurrence is high. This study aimed to analyze the risk
factors for postoperative recurrence or progression of IVL and explore
the impact of different treatment strategies on prognosis.
Design: A retrospective cohort study of IVL patients who
received surgical treatment was performed. Setting: A referral
center for difficult and critical diseases in Obstetrics and Gynecology
in China (Beijing). Population or sample: 114 IVL patients who
received surgical treatment from January 2011 to December 2022 and
received follow-up for ≥ 3 months were enrolled. Methods: Risk
factors for postoperative recurrence or progression of IVL was analyzed
by Kaplan‒Meier survival analysis. Sub-group analysis, including IVL
confined to the uterus and para-uterine vessels, and IVL involving the
iliac vein/genital vein and the proximal veins, was performed to explore
impact of different treatment strategies on prognosis. Main
outcome measures: The primary endpoint was recurrence (for patients
with complete resection) or progression (for patients with incomplete
resection). Results: The median follow-up time was 24 months
(range 3-132 months). Twenty-nine cases (25.4%) recurred or progressed.
The median recurrence or progression time was 16 months (range 3-60
months), and the median progression free survival time was not reached.
Incomplete tumor resection (P=0.019), involvement of the iliac vein or
genital vein (P=0.042), involvement of the inferior vena cava (P=0.025),
and size of pelvic tumor ≥ 15 cm (P=0.034) were risk factors for
recurrence and progression. For IVL confined to the uterus or
para-uterine vessels, the postoperative recurrence rate after
hysterectomy and bilateral oophorectomy was low. Compared to
hysterectomy and bilateral oophorectomy, the recurrence risk after
tumorectomy was significantly increased (P=0.009), and the recurrence
risk after hysterectomy was marginally increased (P=0.058). For IVL
involving the iliac vein/genital vein and the proximal veins,
postoperative aromatase inhibitor treatment (P=0.889) and two-stage
surgery (P=0.862) were not risk factors for recurrence on the premise of
complete tumor resection. Conclusion: Incomplete tumor
resection, extent of tumor lesions and size of the pelvic tumor were
risk factors for postoperative recurrence and progression of IVL. For
IVL confined to the uterus and para-uterine vessels, the recurrence rate
after hysterectomy and bilateral oophorectomy was low. For IVL involving
the iliac vein/genital vein and the proximal veins, aromatase inhibitor
treatment after complete tumor resection did not reduce the risk of
recurrence.
Balanced Scorecard Internal Process Perspective: Applying Data Analytics to Monitor Police Department Performance
Authors: Janvrin Diane J. , Mascha Maureen Francis , Burney Laurie
Published: August 2023

Employers expect graduates to perform data analytics using both organizational and publicly available data. Interestingly, few teaching cases provide students with needed exposure to data analytics in managerial or governmental accounting. In this case, students assume the role of a managerial accountant employed at Municipal Consulting, LLC. Students assist the Police Commissioner in using a Balanced Scorecard approach to analyze how her department responds to crime patterns and to develop next year’s budget. This case requires students to critique, analyze, and evaluate Internal Business Process Perspective Balanced Scorecard measures supported by publicly available data using data visualization software. The case includes instructions for both Tableau and Power BI. The case covers three skills: (1) extract, transform, and load data; (2) develop data visualization software experience; and (3) analyze data. The case is designed for senior level undergraduate and graduate courses in managerial, data analytics, and governmental accounting.
Impact of gestational diabetes detection thresholds on infant growth and body composition: a prospective cohort study within a randomized trial
Authors: Manerkar Komal , Crowther Caroline A. , E Harding Jane , Meyer Michael P. , Conlon Cathryn A. , Rush Elaine C. , Alsweiler Jane M. , McCowan Lesley ME , Rowan Janet A , Edlin Richard , Amitrano Francesca , McKinlay Christopher JD
Published: August 2023

Objective: Gestational diabetes mellitus (GDM) is associated with offspring metabolic disease, including childhood obesity, but causal mediators remain to be established. We assessed the impact of lower versus higher thresholds for detection and treatment of GDM on infant risk factors for obesity, including body composition, growth, nutrition and appetite.

Research design and methods: Prospective cohort study within the GEMS Trial; pregnant women were randomly allocated to detection of GDM using the lower criteria of the International Association of Diabetes and Pregnancy Study Groups or higher New Zealand criteria (ACTRN12615000290594). Randomly selected Control infants of women without GDM were compared with infants exposed to: A) GDM by lower but not higher criteria, with usual treatment for diabetes in pregnancy; B) GDM by lower but not higher criteria, untreated; C) GDM by higher criteria, treated. The primary outcome was whole-body fat mass at 5-6 months.

Results: 760 infants enrolled; 432 assessed for the primary outcome. Fat mass was not significantly different between Controls (2.05kg) and exposure groups: A) GDM by lower but not higher criteria, treated (1.96kg), aMD -0.09 95%CI -0.29,0.10; B) GDM by lower but not higher criteria, untreated (1.94kg), aMD -0.15 95%CI -0.35,0.06; C) GDM detected and treated using higher thresholds (1.87kg), aMD -0.17 95%CI -0.37,0.03.

Conclusion: GDM detected using lower but not higher criteria, was not associated with increased infant fat mass at 5-6 months, regardless of maternal treatment. GDM detected and treated using higher thresholds was also not associated with increased fat mass at 5-6 months.
Acid hydrolases in human skin.
Authors: Ockerman PA.
Published: August 2023

No abstract available
Multiple metastasizing sweat gland carcinomas.
Authors: Damsgaard-Sorensen P , Ohlsen AS.
Published: August 2023

No abstract available
Extramammary paget's disease. A case report.
Authors: Jacobsen KB , Haavelsrud OI.
Published: August 2023

No abstract available
Effects of sex steroids on human skin in organ culture
Authors: Tammi R.
Published: August 2023

Histometric and autoradiographic methods were applied to investigate the actions of sex hormones on the cultured epidermis of post-menopausal women. Both testosterone and progesterone at the concentration of 10(-9)-10(-7) mol/l enhanced the keratinization of the epidermal cells during the 7-day culture. The numbers of the granular cells were increased by both of these hormones and the transit time of the epidermal cells was shortened by progesterone. Progesterone (but not testosterone) influenced cell proliferation, too, as indicated by an increased labelling of the epidermal cells with [3H]thymidine. In a contrast to other sex steroids, 17-beta-estradiol (10(-7) and 10(-9) mol/l) appeared to be ineffective in short-term organ culture.
Herpetiform eruption with leukocytoclasis: a distinctive clinico-pathological variety of erythema multiforme
Authors: Ferrándiz C. , Peyrí J. , Henkes J. , Romagosa V.
Published: August 2023

Six patients are described who experienced a prodromal period suggesting an infective process, followed by a distinctive polymorphous cutaneous eruption. The most striking lesion, present in all of them and giving the eruption a distinctive herpetiform appearance, included closely grouped vesicles resting on an erythematous base. Histopathological examination of these lesions showed features of dermal and epidermal types of erythema multiforme but with prominent leukocytoclasis. We suggest that the clinico-pathological picture of our patients may be considered a distinctive clinico-pathological variety of erythema multiforme.
Exanthema fixum due to ultraviolet radiation
Authors: Langeland J.
Published: August 2023

No abstract available.
Phototoxic reactions from some common drugs provoked by a high-intensity UVA lamp
Authors: Rosén K. , Swanbeck G.
Published: August 2023

No abstract available.
Histamine receptor bearing suppressor cells in nickel sensitivity
Authors: Silvennoinen-Kassinen S.
Published: August 2023

No abstract available.
Tyrosinase-negative albinism with congenital malformations and squamous cell carcinoma of the genitalia
Authors: Claudy AL. , Ortonne JP.
Published: August 2023

No abstract available.
Incontinentia pigmenti with dental anomalies: a three-generation study
Authors: Bjellerup M.
Published: August 2023

No abstract available.
On the nature of idiopathic guttate hypomelanosis
Authors: Wilson PD. , Lavker RM. , Kligman AM.
Published: August 2023

Clinical and morphologic studies were made of 20 cases of guttate hypomelanosis. The sharply demarcated hypopigmented macules were present on both covered and exposed sites, excluding sunlight exposure as a cause. Skin surface replicas and biopsies showed no evidence of post-traumatic or post-inflammatory scarring. The stratum corneum had fewer cell layers, but no abnormalities of keratinization were observed. Light and electron-microscopic and histochemical studies showed only reduced numbers of hypoactive melanocytes. In no case were melanocytes completely absent, excluding vitiligo. Guttate hypomelanosis is a common disorder of unknown origin. The evidence indicates an age-related somatic mutation of melanocytes.
Persistent pruritic papules from deer ked bites
Authors: Rantanen T. , Reunala T. , Vuojolahti P. , Hackman W.
Published: August 2023

Deer ked (Lipoptena cervi L.), a haematophagous louse fly of deer, also attacks man and can cause persistent pruritic papules. Nineteen patients with this conditions were examined. They suffered attacks while carrying out their work, or merely walking, in forested areas. The bite papules appeared mostly on the head and back. They were very itchy and resistant to treatment and persisted from 2 weeks up to 12 months. Histologically, a typical insect bite reaction was found without any signs of retained deer ked mouth parts. Direct immunofluorescence showed deposits of C3 in dermal vessel walls in 7 of the 11 papules examined. Skin tests with a deer ked whole body extract were positive in all patients tested, showing both immediate and delayed reactions. Moreover, 57% of the patients tested had elevated serum IgE levels. All these findings suggest that IgE, complement and cell-mediated immune mechanisms are involved in the pathogenesis of deer ked bite reactions.
Thalidomide in the treatment of chronic discoid lupus erythematosus
Authors: Hasper MF. , Klokke AH.
Published: August 2023

No abstract available.
The role of immune complexes in early syphilis and in the Jarisch-Herxheimer reaction
Authors: Sølling J. , From E. , Mogensen CE.
Published: August 2023

Circulating immune complexes (CIC) were detected in one of 11 patients with primary syphilis and in 5 of 12 patients with secondary syphilis. The level of CIC was significantly increased in patients with secondary syphilis. Four weeks later a significant decline in CIC was found. No relationship was demonstrated between CIC and affection of the skin, lymph nodes, or kidneys. An increased albumin excretion rate was demonstrated before treatment. No differences were found in the excretion rate of beta-2-microglobulin before or after treatment. Nineteen patients had a Jarisch-Herxheimer reaction during treatment. An increase in CIC was found in 5 patients and a decrease in 7 patients. No correlation could be demonstrated between the level of or changes in CIC and the severity of the Jarisch-Herxheimer reaction.
Palmar hyperlinearity in atopic dermatitis
Authors: Høyer H. , Agdal N. , Munkvad M.
Published: August 2023

No abstract available.
Balanitis circumscripta plasmacellularis: case report with ultrastructural study
Authors: Leonforte JF.
Published: August 2023

A typical case of balanitis circumscripta plasmacellularis is described in a 74-year-old man. Electron microscopy revealed a dense infiltrate composed mainly of plasma cells and macrophages; the former showed considerable rough endoplasmic reticulum and phagolysosomes, while the latter contained variable amounts of sideromes. A few mast cells, eosinophils and extravasated erythrocytes were also present. Connective tissue was scarce; no elastic fibres and viral particles were seen.
Blood viscosity and psoriasis
Authors: Dal Bo Zanon R. , Procidano M. , Cipriani R. , Saltarin P. , Peserico A. , Girolami A.
Published: August 2023

No abstract available.
The histochemistry of the Merkel cell neuroepithelial endings in cat and rabbit skin and oral mucosa
Authors: Winkelmann RK.
Published: August 2023

The tactile hair disks in the oronasal area of the rabbit registered positive for specific and nonspecific cholinesterase. In the cat, the tactile hair disks were positive for alkaline phosphatase in the same region. The hederiform Merkel-Ranvier ending in the epidermis of the palate was positive for cholinesterase in the rabbit and positive for alkaline phosphatase in the cat. In the rabbit, 4-methoxyleucine aminopeptidase activity was also demonstrated in the focal palate epithelium associated with nerves of the Merkel-Ranvier ending. These histochemical reactions of the Merkel neuroepithelial complexes are associated with the nerve ending and may be a specific indicator of the species´ innervation pattern.
Dermatitis herpetiformis with linear IgA deposition: ultrastructural localization of in vivo bound IgA
Authors: Yamasaki Y. , Hashimoto T. , Nishikawa T.
Published: August 2023

Ultrastructural localization of bound IgA in the skin of a patient suffering from dermatitis herpetiformis with linear IgA deposition at the dermo-epidermal junction was studied using the horseradish peroxidase labelled antibody method. The reaction products were observed as electron-dense materials, not only immediately below the cytomembrane of the basal cells but also in the uppermost dermis just below the basal lamina. The major portion of the lamina lucida was free of the reaction products. These findings suggest a diversity in the mode of IgA deposition and the possibility of the presence of different antigens in the basement membrane zone, to which IgA class antibodies may be bound respectively.
Impairment of some microphage functions in recurrent herpes simplex
Authors: Simon Jr M. , Djawari D.
Published: August 2023

Chemotactic, phagocytic and intracellular killing activities of polymorphonuclear leukocytes (PMNL) were investigated in vitro in 49 patients suffering from recurrent bouts of herpes simplex. A slight impairment of chemotactic activity and a markedly reduced capacity of killing Candida albicans blastospores were revealed. Phagocytic capacity and NADH-dependent oxidase activity of PMNL proved to be normal. The results point to an alteration of some PMNL functions in these patients.
65Zinc absorption in untreated and D-penicillamine-treated patients with generalized scleroderma: determination by whole-body counting technique
Authors: Høyer H. , Hvid-Jacobsen K. , Weismann K.
Published: August 2023

65Zinc absorption in patients suffering from generalized scleroderma was studied by means of whole-body counting technique following a single dose of 65Zn. In 4 untreated patients the mean 65Zn absorption was calculated to 35% (range 20-59%). Five patients receiving oral D-penicillamine had a numerically higher mean absorption value of 55% (range 37-74%). The results corroborate earlier studies on the effect of D-penicillamine on 65Zn absorption in rats.
Photobinding of 8-methoxypsoralen at psoriasis skin
Authors: Meffert H. , Sönnichsen N.
Published: August 2023

No abstract available.
Immunofluorescence studies on complement components in lichen amyloidosus
Authors: Sudo S. , Igarashi R. , Morohashi M.
Published: August 2023

Immunofluorescence studies were carried out in 7 cases of lichen amyloidosus, chiefly to detect deposition of complement components in the cutaneous lesions. Examination of skin biopsy specimens revealed deposition of Clq, C3, C9 and IgM in all the patients studied. Complement and immunoglobulin levels by assays of simultaneously obtained serum samples were found to be almost within the normal limits.
Leukoderma syphiliticum: ultrastructural observations on melanocyte function
Authors: Frithz A. , Lagerholm B. , Kaaman T.
Published: August 2023

A case of genital leukoderma syphiliticum was analysed submicroscopically. No treponema pallidum organisms could be detected intra- or extracellularly in the epidermis or in the dermis. The melanocytes were only slightly reduced in number and had mostly normal outlines. The melanogenesis was impaired and small melanosomes with decreased deposition of melanin were mostly produced at the expense of normal melanin granules. A partial block in the melanin transfer mechanism seems to be in evidence. As no direct destructive action of spirochetes on the melanocytes is observed, an indirect effect is assumed, e.g. by a tyrosinase inhibitor.
"Herpetiform eruption with leukocytoclasis" = Sweet´s Syndrome?
Authors: Harms M. , Chavaz P. , Saurat JH.
Published: August 2023

No abstract available.
Vaginal involvement in familial benign chronic pemphigus (Morbus Hailey-Hailey)
Authors: Václavínková V. , Neumann E.
Published: August 2023

Vaginal pain over a period of 3 years has been shown to be based on a vesiculo-bullous acantholytic disorder suggesting familial chronic benign pemphigus (Morbus Hailey-Hailey). Local applications of 5 ml 1% hydrocortisone-enterochinol cream resulted in an almost total regression of all the symptoms, including dyspareunia.
Ketoconazole in a case of chronic mucocutaneous candidiasis
Authors: Zachariae H. , Laurberg G. , Thestrup-Pedersen K.
Published: August 2023

An 8-year-old girl with chronic mucocutaneous candidiasis was treated with Ketoconazole 100 mg daily for 6 weeks. Oral thrush disappeared after a week, while cutaneous lesions cleared within a month. Her nail dystrophy disappeared during the following months. Repeated cultures were negative for Candida albicans. The patient has remained in remission for an 8-month period. Our findings thus support previous reports indicating that Ketoconazole is an effective agent against this disease.
Pemphigus serum-induced loss of microvilli from human epidermal cells
Authors: Hietanen J. , Salo OP. , Kariniemi AL.
Published: August 2023

Scanning electron microscopic examination of human epidermal cells prepared from suction blister roofs by treatment with trypsin and dithioerythritol and incubated (37 degrees C, 18 hours) with pemphigus sera revealed a smooth or wrinkled surface texture in 83 to 96% and surface microvilli in only 17 to 4%. The disappearance of microvilli was not affected by the presence of complement. In the control specimen 54% of the cells retained their microvilli. The difference between cells incubated with pemphigus and those incubated with control sera was highly significant (p less than 0.001). Epidermal cell suspensions were also incubated with pemphigus vulgaris sera plus a protease inhibitor (ovomucoid). The loss of microvilli from human epidermal cells induced by pemphigus vulgaris serum was highly significantly inhibited by ovomucoid (p less than 0.001). The results suggest that the loss of microvilli induced by pemphigus sera, irrespective of the presence of complement, may be an important factor in acantholysis of pemphigus. Proteolytic enzymes may be responsible for the loss of microvilli and smoothing of the cell surface of human epidermal cells in vitro.
Linear IgA dermatosis: a study of ten adult patients
Authors: Mobacken H. , Kastrup W. , Ljunghall K. , Löfberg H. , Nilsson LA. , Svensson A. , Tjernlund U.
Published: August 2023

Ten adult patients with homogeneous-linear deposition of IgA along the basement membrane zone have been studied. The direct immunofluorescence IgA pattern was stable, and there was no deposition of IgG or IgM. The clinical presentations were heterogeneous and resembled dermatitis herpetiformis (DH) (3 cases) or bullous pemphigoid (5 cases). Two patients had widespread gyrate blistering lesions of acute onset. Pruritus was constantly present. The course of the disease was chronic except for one patient who had a spontaneous remission after 5 years. The histology was indistinguishable from "classical" DH with granular IgA in dermal papillae. The patients studied in the present investigation did not show the high incidence of atrophic intestinal villi found in "classical" DH. Five of 9 cases carried the haplotype HLA-A1, B8, DR3. In spite of a close similarity between linear IgA dermatosis and DH, differences exist which indicate discrepancies in etiopathogenesis.
Passive transfer of idiopathic cold urticaria to monkeys
Authors: Misch K. , Black AK. , Greaves MW. , Almosawi T. , Stanworth DR.
Published: August 2023

No abstract available.
Quantification of alkaline phosphatase in lesions and uninvolved skin of psoriatic patients
Authors: Van de Kerkhof PC. , Van Rennes H. , Mier PD.
Published: August 2023

Alkaline phosphatase (ALP) has been quantified in psoriatic skin for the first time. The levels of both the soluble and the particulate forms of this enzyme were grossly elevated in psoriatic lesions; by contrast, levels in the clinically uninvolved skin of the patient were normal. The changes in the lesion cannot be explained solely in terms of vasodilatation, since UVR-induced erythema was accompanied only by a modest increase in soluble ALP activity.
Results of lymphography in early mycosis fungoides
Authors: Zachariae H. , Bjerring P. , Grunnet E. , Thestrup-Petersen K. , Davidsen D.
Published: August 2023

Lymphography was performed in 28 patients with mycosis fungoides. In 22 of the patients, the investigation took place prior to 2 months after the diagnosis was established, and in 7 of these lymphography was made before the histological verification of mycosis fungoides was possible. Five patients with widespread, persistent and severe atopic dermatitis served as controls. Eighteen patients with mycosis fungoides (64%) had abnormal lymphograms, while all 5 controls had normal lymphograms. Abnormal findings were diagnosed in 12 of 22 patients at the earliest time possible during the course of their disease and even found in 5 of 7 patients who only had premycotic lesions at the time of investigation. These results may have some bearing on therapy, suggesting that systemic treatment could possibly be introduced at a far earlier disease stage than is the custom at present.
Arginase activity and polyamine biosynthesis in psoriasis
Authors: Lauharanta J. , Käpyaho K.
Published: August 2023

Polyamine biosynthesis and arginase activity in psoriasis were studied using keratotome strips and suction blister roofs as specimens. In the uninvolved psoriatic skin a slight (1.3-fold; p less than 0.05) increase in the spermidine level was observed compared with control skin. There was also a 1.2-fold increase (p less than 0.05) in the spermidine/spermine molar ratio, which is considered to be an indicator of proliferation activity. No changes were noted in other polyamines or polyamine-synthesizing enzymes ornithine decarboxylase (ODC) and S-adenosyl-L-methionine decarboxylase (AMDC) in the uninvolved psoriatic skin vs. control skin. Neither was there any significant difference in the arginase activity. In psoriatic lesions the levels of all polyamines, as well as the activities of biosynthetic enzymes, were significantly (p less than 0.001) elevated. The putrescine level was elevated to 2.5-fold, spermidine to 2.7-fold and spermine to 1.4-fold. The enzyme activities expressed severalfold increases. The enhancement of arginase activity was less prominent than that of polyamine-synthesizing enzymes, but the increase from 271 +/- 88 to 354 +/- 126 mumol/g/h (1.3-fold) was statistically significant (p less than 0.001; paired t-test). The increase in arginase activity in suction blister roofs, which represents pure epidermis, was more pronounced than that in keratotome strips, i.e. about double. The results show thus that polyamine biosynthesis is significantly enhanced in psoriatic lesions, but there is only a slight difference between the uninvolved psoriatic skin and control skin.(ABSTRACT TRUNCATED AT 250 WORDS)
Seborrhoeic dermatitis of the face induced by PUVA treatment
Authors: Tegner E.
Published: August 2023

Seborrhoeic dermatitis of the face was observed in 28 of 347 patients treated with PUVA for psoriasis. The facial lesions appeared after discontinuation of PUVA, and had not been present at the start of PUVA treatment. They were prevented by masking the face during irradiation.
Identification of 5,6-dimethoxyindolyl-2-carboxylic acid in melanotic urine
Authors: Pavel S. , Elzinga H. , Muskiet FA. , Wolthers BG.
Published: August 2023

5,6-dimethoxyindolyl-2-carboxylic acid was identified in urine of patients with malignant melanoma by means of gas chromatography - mass spectrometry. Its presence supports the concept of the existence of an efficient methylating activity in melanoma tissue.