bluuebunny/crossref_metadata_2025 huggingface dataset:
Communication noise of product innovation promotion process
Authors: Aleksandrova I. Yu.
Published: October 2024

The communicative noise phenomenon as a destructive element of marketing communication aimed at promoting product innovation has been analyzed. In the process of solving the set tasks the attention has been focused on the study of communicative noise of recipient and addressee of marketing information about an innovative product, since the noises of this type are the most complex and problematic ones due to their latency and weak controllability. Their essence lies in errors/failures of coding-decoding of marketing information in the process of a company’s interaction with potential consumers of its product innovation. As the conducted research result, the following communicative noises of recipient and addressee of marketing information about an innovative product have been identified and analyzed: incorrect positioning of an innovation; semantic dissonance of the brand image and its product innovation; incorrect advertising concept of an innovation; weak or incorrect creative idea of the innovation advertising; incorrect choice of tools for promoting an innovation; differences in the perception of an innovation related to social and demographic characteristics of consumers (gender, sex, age, education, and income), consumers’ belonging to one or another culture (cultural and ethnic or religious affiliation), and individual-psychological characteristics (personality type, individual value system, degree of dependence on the social environment, and the level of resistance to psychological influence).
Issues of the Russian liquefied natural gas market in the context of sanctions pressure and ways to solve them
Authors: Laznik A. A. , Gordeeva T. S.
Published: October 2024

Liquefied natural gas export is currently a rather promising sector of the Russian fuel and energy complex. Gas transportation by special gas carriers makes it possible to supply the resource independently of the pipeline system. In recent years, the liquefied natural gas market role has been significant for the Russian economy. This industry has not been subject to significant export restrictions by other countries, unlike pipeline gas exports. However, under the conditions of sanctions imposed by “unfriendly” countries on the supply of technologies and equipment required for liquefied natural gas production and transportation, not only the industry development, but also implementation of the Energy Strategy of the Russian Federation for the period up to 2035 is threatened, especially major projects implementation on the Arctic coast of the country. All of the above speaks for the relevance of the study, the objectives of which are to assess the Russian market of liquefied natural gas in the context of the introduced technological restrictions, to identify the key problems arising as a result of this unfavorable situation and to determine the directions for the industry further development.
Citrus IntegroPectin: a multifunctional bioactive phytocomplex with large therapeutic potential
Authors: Ciriminna Rosaria , Di Liberto Valentina , Valenza Chiara , Li Petri Giovanna , Angellotti Giuseppe , Albanese Lorenzo , Meneguzzo Francesco , Pagliaro Mario
Published: October 2024

Pectin is a bioactive polysaccharide widely investigated for its therapeutic properties as well as in tissue engineering and regenerative medicine for its gelling behavior, wound healing ability and high biocompatibility. First isolated in 2019 via hydrodynamic cavitation carried out in water only of the by-product of the industrial process of manufacturing orange juice, IntegroPectin is a new pectin-based phytocomplex rich in citrus flavonoids and terpenes whose low-methoxyl pectin backbone is enriched in RG-I rhamnogalacturonan regions. Antioxidant, anti-inflammatory, cardioprotective, neuroprotective, mitoprotective, antimicrobial and anticancer properties comprise the multitarget biological activity demonstrated so far investigating lemon, grapefruit, and mandarin IntegroPectin in both in vitro and in vivo studies. Research achievements in the first five years following its discovery highlight the large potential of citrus IntegroPectin as therapeutic and preventive agent. A critical perspective towards production and practical uptake of this new phytocomplex for the treatment and prevention of numerous ailments concludes the review.
Molecular Aharonov-Bohm Interferometers Based on Porphyrin Nanorings
Authors: Cheng Chi , Harari Gil , Rončević Igor , Peralta Juan , Anderson Harry , Wibowo-Teale Andrew , Hod Oded
Published: October 2024

A goal of molecular electronics and spintronics is to create molecular devices that change their conductance in response to external stimuli. The Aharonov-Bohm (AB) effect implies that an electronic device formed from a quantum ring and metallic leads will exhibit such behavior under external magnetic fields. At first sight, it appears that unrealistically large fields would be required to significantly alter the conductance of a molecular ring. However, the sensitivity of a molecular AB interferometer to magnetic fields can be increased by weakening the coupling between the molecular ring and the metallic leads. An ideal molecular ring for an AB interferometer has a large radius (to access a larger portion of the full AB cycle), and a small effective mass (high electron mobility) to enhance its response to magnetic fields. Here, we use computational modelling to demonstrate that recently synthesized porphyrin nanorings, with radii of 2–9 nm, could behave as molecular AB interferometers at achievable magnetic field strengths (5–10 T), if weak ring-lead coupling is used. Building on our recently developed semi-empirical approach, which incorporates the effects of finite magnetic fields on the electronic structure, we develop a transport computational platform that allows us to identify sharp Fano resonances in the transmittance probability of porphyrin nanorings that could be exploited to control the current with an applied magnetic field. These resonances are rationalized in terms of a magnetic field-induced delocalization of the molecular orbitals. Our findings indicate that molecular AB interferometry should be feasible with current experimental capabilities.
A Molecularly Impermeable Polymer from Two-Dimensional Polyaramids
Authors: Ritt Cody , Quien Michelle , Wei Zitang , Gress Hagen , Dronadula Mohan , Altmisdort Kaan , Tu Yu-Ming , Gadaloff Michael , Aluru Narayana , Ekinci Kamil , Bunch Scott , Strano Michael
Published: October 2024

All polymers exhibit gas permeability through the free volume of entangled polymer chains. However, two-dimensional (2D) materials including graphene stack densely and can exhibit molecular impermeability. Solution-synthesized 2D polymers that exhibit the latter by poly-condensation have been a longstanding goal. Herein, we demonstrate self-supporting, spin-coated 2D polyaramid nanofilms that exhibit nitrogen permeability below 3.1E-9 Barrer, roughly 6500-fold lower than existing polymers, and similar for other gases. Optical interference during the pressurization of nanofilm-coated microwells allows measurement of mechanosensitive rim opening and sealing, creating gas-filled bulges stable exceeding 3 years. This discovery enables 2D polymer resonators with high resonance frequencies (~8 MHz) and Q factors up to 537, similar to graphene. A 60-nm coating of air-sensitive perovskites reduces the lattice degradation rate 14-fold with an oxygen permeability of 3.3E-8 Barrer. Molecularly impermeable polymers promise the next generation of barrier materials that utilize exceedingly little polymer to maximize chemical rejection, ultimately contributing to sustainable materials development.
New capabilities of the gmx2qmmm software
Authors: Anders Florian , Jansen Alina , Alnicola Nicola , Pi Yuan-Wei , Petry Simon , Kapp-Joswig Jan-Oliver , Artiukhin Denis G. , Götze Jan Philipp
Published: October 2024

We present an update to the hybrid quantum mechanics/molecular mechanics (QM/MM) interface “gmx2qmmm”. Version 2.0 of the software is now capable of interfacing between the more recent versions of the MM package Gromacs and various other QM packages, in addition to the previously supported Gaussian16. The additional QM packages are ORCA, Turbomole and Serenity; especially the latter drastically increases the potential for QM/MM with extensively large QM regions. While the implementation of the QM packages was for most cases analogous to Gaussian, updating the compatibility to recent Gromacs versions required omission of large parts of the system, which was previously done via the now deprecated energy group exclusion scheme. The new version, gmx2qmmm 2.0, explicitly removes any surplus atoms or point charges that are not affecting the potential of any unrestrained atom (active region). It is thus more consis- tent with previous QM/MM publications, which often reduce the computational workload by deleting all but the necessary parts of the solvent shell. We fur- ther introduced numerical normal mode analyses and a linear coordinate scan function to facilitate basic potential energy surface studies, both for electronic ground and excited states.
Multiliter Scale Photosensitized Dimerization of Isoprene to Sustainable Aviation Fuel Precursors
Authors: Cid Gomes Leandro , Vajravel Sindhujaa , Siljebo William , Rana Anup , Gustafsson Tomas , Ottosson Henrik
Published: October 2024

Synthetic routes to sustainable aviation fuels are needed to mitigate environmental impacts of the aviation sector. Among several emerging methods, the use of light-driven reactions benefits from milder conditions and the possibility of using sunlight to directly irradiate reactants, or alternatively, to power LEDs with a high and constant light intensity. Dinaphthylketone photosensitized dimerization of isoprene can afford C10-cycloalkenes that, after hydrogenation, meet the required properties for jet fuels (strongly resembling Jet-A). Isoprene can be photobiologically produced by metabolically engineered cyanobacteria from the conversion of CO2 and water by utilizing solar light, contributing to a carbon-neutral process. The scale-up of such a combined photobiological-photochemical route is essential to bring it closer to a commercial level. Herein, we present the optimization and scale-up of the photosensitized dimerization of isoprene. By designing different reactor setups, flow versus no-flow conditions and LED lamps (λmax = 365 nm) versus sunlight as the light source, we reached a 2.6 liter-scale able to produce 61 mL of isoprene dimers per hour, which represents a 14-fold higher productivity compared to our previous results at smaller scale. We also demonstrated a continuous feed process converting isoprene into dimers with a 95% yield under LED irradiation. These advancements highlight the potential of light-driven processes to contribute to the energy transition and production of sustainable aviation fuels, making them more viable for commercial use and significantly reducing the environmental impact of the aviation sector.
How Do Microbial Metabolites Interact with Their Protein Targets?
Authors: Astigarraga Mario , Sánchez-Ruiz Andrés , Diop-Aw Aminata , Quintero Raquel , Colmenarejo Gonzalo
Published: October 2024

The design of drugs and nutraceutics that mimic microbial metabolites is an emerging drug modality in medicinal chemistry that attempts to modulate the myriad of interactions that these molecules establish with host and microbial proteins. Understanding how microbial metabolites interact with their target proteins is key to perform a rational design of metabolite mimetic molecules for therapeutic usage. In the present work we answer that question by analyzing the functional groups of these molecules, and the interactions they display in a set of more than 71 K protein-metabolite interactions from the PDB. Significant differences in the functional group distributions, their chemical features, and their co-occurrences, are observed for distinct subsets of these molecules. The same is true for the distributions of interaction types. By correlating both datasets, we are able to explain the observed interaction patterns in terms of observed functional group patterns. These results will shed light on the rational design of novel metabolite mimetic molecules for therapeutic purposes.
Towards an Understanding of Linear Scaling Relations Through Energy Decomposition Analysis
Authors: Di Censo Jesse , Lander Chance , Pei Zheng , Le Tien , Kusun Kalhara Gunasooriya G. T. , Wang Bin , Mao Yuezhi , Shao Yihan
Published: October 2024

The discovery of linear scaling relations has fundamentally changed the field of heterogeneous catalysis. While the scaling relations have been rationalized based on a separation of sp and d electron contributions to adsorption energies, a full understanding of such a separation would require one to further break the adsorp- tion energy into distinct energy components such as electrostatics, polarization, charge transfer, and van der Waals components, and examine the sp and d contributions to each of them. As a first step in this direction, we analyze the interaction energy between CHx adsorbates and fcc(100) transition metal surfaces (M = Cu, Ag, Au, Rh, and Pt), with the surfaces represented both as slabs in plane-wave density functional theory (pw-DFT) calculations and as atomic clusters in atomic-orbital basis density functional theory (ao-DFT) calculations. Through an absolutely-localized molecular orbital (ALMO) based energy decomposition analysis of the ao- DFT adsorption energy, each of the interaction energy components (electrostatics, polarization, van der Waals, and charge transfer) was found to follow its own scaling relations, with an intricate in- terplay among these energy components yielding the overall scaling relations for the total adsorption energies. Using the recently in- troduced ALMO-based polarization and charge-transfer analysis schemes, we further dissected polarization into metal surface and adsorbate contributions, and charge transfer into metal→adsorbate and adsorbate→metal contributions. The contributions from the sp and d electrons of metal to these terms were further quantified. These analysis results shed light on how CHx adsorbates interact with metal surfaces and reveal the physical origin of the scaling relations.
Efficacy and safety of bioregulatory peptides in the treatment of prostate diseases: a review
Authors: Yakovlev Andrey V. , Saverskaya Elena N. , Ershov Anton V.
Published: October 2024

The article describes the risk factors, pathogenetic mechanisms of development of various prostate diseases and highlights the problems in their treatment. Information on regulatory peptides and their mechanism of action is presented. Clinical studies proving the high effectiveness of bioregulatory peptides in the treatment of chronic prostatitis, chronic pelvic pain syndrome and benign prostatic hyperplasia are presented. The analysis was carried out and evidence of the effectiveness of domestic drugs Prostatex and Prostateks Plus in the treatment of prostate diseases was presented.
Experience in the treatment of patients with androgenic deficiency and comorbidity pathology
Authors: Osipov Arsen V. , Derevyanko Tatyana I. , Agranovich Nadezhda V. , Frantsev Roman S. , Babasheva Gayane H. , Alexandrova Olga A.
Published: October 2024

Background. Age-related involution of the male reproductive system, known as testosterone deficiency syndrome, andropause, androgen deficiency in the aging male, or partial androgen deficiency in the aging male, causes clinical manifestations that impair quality of life and increase the risk of mortality, especially from cardiovascular disease. In Russia, the problem of hypodiagnosis of androgen deficiency remains up-to-date, with a low frequency of prescription of replacement therapy.
Aim. At assessing the effectiveness of testosterone in the rehabilitation of patients with hypogonadism and cardiovascular pathology.
Materials and methods. It involved 36 men aged 25–75 years with various cardiological pathologies.
Results. As a result of the study, testosterone as a form of a transdermal gel is effective at doses of 50 mg/day. Three-month use of testosterone gel increases the level of testosterone to 2.9 nmol/l (p0.05).
Conclusion. Thus, testosterone may play a key role in the treatment of hypogonadism and related cardiovascular diseases, although its safety and feasibility remain a matter of debate.
Normative Reference Values and Validity for the 30-Second Chair-Stand Test in Healthy Young Adults
Authors: Lein Donald H. , Alotaibi Mansour , Almutairi Marzouq , Singh Harshvardhan
Published: October 2024

Background

Clinicians often use physical performance tests (PPT) to measure performance measures in sports since they are easy to administer, portable, and cost-efficient. However, PPT often lack good or known psychometric properties. Perhaps, the 30-second chair-stand test (30CST) would be a good functional test in athletic populations as it has been shown to demonstrate good psychometric properties in older adults.

Hypothesis/Purpose

The purpose of this study was to determine normative values for and concurrent, convergent and discriminative validity of 30CST for healthy young adults aged 19-35 years.

Study Design

Cross-sectional

Methods

Eighty-one participants completed this study. All participants performed two trials of 30CST, 5-times sit-to-stand (5xSTS), and lateral step-up test (LSUT). Investigators used the International Physical Activity Questionnaire Leisure Domain (LD-IPAQ) to divide participants into insufficiently or sufficiently active groups based on the weekly metabolic equivalent of task per the Physical Activity Guidelines for Americans.

Results

Participants (Mean + SD age, 25.1 ± 3.4 years; body height, 1.71 ± 0.09 m; body mass, 72.6 ± 16.1 kg; females 47) performed an average of 33.0±5.4 30CST repetitions. The 30CST performance was negatively associated with 5xSTS (r=-0.79 p=0.01) and positively associated with LSUT performances (r=0.51, p=0.01) when using Pearson correlations. In addition, the sufficiently active group performed significantly greater 30CST repetitions than the insufficiently active group (mean difference = 2.5; p=0.04).

Conclusions

In addition to finding a reference value for 30CST performance in young adults, investigators found that the 30CST displayed concurrent and convergent validity in assessing functional lower extremity (LE) muscle strength and discriminated between those with sufficient and insufficient physical activity levels. Training and rehabilitation professionals could use the 30CST for testing functional LE muscle strength for athletes in pre-season or during rehabilitation. Future investigators should perform studies to determine if 30CST predicts sport performance.

Level of Evidence

Level 2
Clinical experience of cone-beam computed tomography in interventional neuroradiology
Authors: Shchehlov D.V. , Chebanyuk S.V. , Svyrydiuk O.E. , Konotopchyk S.V. , Sydorenko O.F. , Pankiv V.R. , Vyval M.B.
Published: October 2024

Objective ‒ to analyze the experience of using cone-beam computed tomography (CBCT) angiography during diagnostic and interventional procedures in the SO «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine».Materials and methods. Informed consent was obtained from each patient (parent or guardian) enrolled in the study and the study protocol conforms to the ethical guidelines of the Declaration of Helsinki as reflected in a priori approval by the Institutional Ethical Review Board (Institution's Human Research Committee). Since January 2024 in the SO «Scientific-Practical Center of Endovascular Neuroradiology NAMS of Ukraine» used in practical work a modern angio machine «Siemens Artis Q.zen» (Siemens, Erlangen, Germany), equipped with a set of various techniques and programs, in particular CBCT, syngo Aneurysm Guidance Neuro, 3D Roadmap. We analysed 36 diagnostic and interventional procedures was conducted from January 2024 to March 2024, during which CBCT was used. Among the procedures, 29 cases of brain aneurysms, 4 arteriovenous malformations and 3 cases of dural arteriovenous fistulas.Results. CBCT is useful for understanding vascular anatomy and allows for more detailed visualization of the curvilinear course of vessels in 3D space along any plane with the possibility of their correlation with bone structures compared to traditional angiography, and also has a higher resolution compared to more common 3D digital subtraction angiography. CBCT images are also a valuable source of information for further understanding of both pathological and normal neurovascular anatomy. Our center has implemented rotation 3D images with contrast of the CBCT at the stage of preparation and planning of the interventional procedure, rotation with subtraction (3D-DSA) ‒ to control implanted devices and its relationship to the vessels and long-term rotation of the CBCT without contrast ‒ to control the straightening and positioning of the stent. To control the position of the stent and its relations to the vessels, the «fusion» mode was used, providing additional information about the vascular structures imposed during conventional angiography, as well as the ability to rotate the volume at any angle regardless of the mechanical capabilities.Conclusions. CBCT is an accessible and unique function of modern angiomachines and helps to improve the understanding of anatomical features in various pathologies of cerebral vessels and helps in making clinical decisions.
Endovascular intervention using combined percutaneous access in a patient with recurrence of critical ischemia after repeated bypass operations on arteries of the lower extremities (clinical case)
Authors: Vereschagin S.V. , Abramenko A.V. , Slobodyanyuk O.V. , Annyshinets Ya.M.
Published: October 2024

Unsatisfactory long-term results of shunting operations on the arteries of the lower extremities are most often caused by a stenotic process followed by thrombosis in the anastomotic zone, especially in combination with the progression of the underlying disease and the spread of obstructive atherosclerotic lesions on the inflow and outflow arteries. A clinical case of endovascular treatment of a patient with peripheral arterial disease is presented, who previously underwent 3 reconstructive bypass operations on the arteries of the lower extremities within 15 months before hospitalization, but again sought medical help due to the recurrence of critical ischemia of the left lower extremity. Considering the high risk of repeated open surgery due to the patient’s comorbidity (diabetes mellitus and extensive Q-myocardial infarction, suffered after the first bypass surgery), as well as gross scar changes after previous vascular operations, it was decided to perform endovascular intervention using a non-standard combined percutaneous approach. Iliac artery stenosis and post-thrombotic occlusion of the popliteal artery in the area of the distal anastomosis of the femoral-popliteal bypass graft on the left side were detected on the preoperative MSCT with intravenous contrast enhancement. Because of the gross postoperative scars, we could not use standard percutaneous approaches through any of the femoral arteries. Access through the arteries of the upper limbs also did not ensure the operation on all affected segments due to the long distance to the intervention zone and absence of instruments of the required length. Therefore, in order to maximally solve the tasks of the operation, we simultaneously used an antegrade left transaxillary access and a transpedal retrograde access through the left foot artery. Thus, the patient underwent simultaneous balloon angioplasty of stenoses of the common and external iliac arteries on the left side by transaxillary access, as well as balloon angioplasty and implantation of a coronary drug-eluting stent in the popliteal artery in the area of the distal anastomosis of the femoral-popliteal bypass graft by retrograde transpedal access on the left. As a result, the magistral arterial blood flow of the limb and the function of the shunt were completely restored with a good angiographic and clinical result.The applied methods of endovascular treatment have shown high efficiency and can be recommended as an alternative to traditional vascular surgery.
A Review of Research on Handwritten Chinese Character Recognition with Multi-Feature Fusion
Authors: Deng Peng , Yang Guiying
Published: October 2024

This paper analyzes the progress of handwritten Chinese character recognition technology, from two perspectives: traditional recognition methods and deep learning-based recognition methods. Firstly, the complexity of Chinese character recognition is pointed out, including its numerous categories, complex structure, and the problem of similar characters, especially the variability of handwritten Chinese characters. Subsequently, recognition methods based on feature optimization, model optimization, and fusion techniques are highlighted. The fusion studies between feature optimization and model improvement are further explored, and these studies further enhance the recognition effect through complementary advantages. Finally, the article summarizes the current challenges of Chinese character recognition technology, including accuracy improvement, model complexity, and real-time problems, and looks forward to future research directions.
A Novel Optimization Scheme for Named Entity Recognition with Pre-trained Language Models
Authors: Li Shuanglong , Zhang Xulong , Wang Jianzong
Published: October 2024

Named Entity Recognition (NER) is crucial for extracting structured information from text. While traditional methods rely on rules, Conditional Random Fields (CRFs), or deep learning, the advent of large-scale Pre-trained Language Models (PLMs) offers new possibilities. PLMs excel at contextual learning, potentially simplifying many natural language processing tasks. However, their application to NER remains underexplored. This paper investigates leveraging the GPT-3 PLM for NER without fine-tuning. We propose a novel scheme that utilizes carefully crafted templates and context examples selected based on semantic similarity. Our experimental results demonstrate the feasibility of this approach, suggesting a promising direction for harnessing PLMs in NER.
Cutting-Edge Challenges in Communication Technology and Computer Network Security
Authors: Gu Haikang
Published: October 2024

The rapid development of communication technology and computer networks has brought a lot of convenience to production and life, but it also increases the security problem. Information security has become one of the severe challenges faced by people in the digital age. Currently, the security problems facing the field of communication technology and computer networks in China mainly include the evolution of offensive technology, the risk of large-scale data transmission, the potential vulnerabilities introduced by emerging technology, and the dilemma of user identity verification. This paper analyzes the frontier challenges of communication technology and computer network security, and puts forward corresponding solutions, hoping to provide ideas for coping with the security challenges of communication technology and computer networks.
Economic Overhaul Mode of Steam Engine Professional Equipment in Thermal Power Plant
Authors: Wang Rui
Published: October 2024

To ensure that the daily production activities of thermal power plants can produce their due effect in the production and business activities, it is necessary to carry out efficient and orderly maintenance work on the professional equipment of steam engines. However, the maintenance work of steam engine professional equipment in thermal power plants usually uses high-cost expenditures. Therefore, how to take effective measures to reduce the cost of professional equipment maintenance in thermal power plants has become a problem that needs to be solved before such maintenance can proceed. Among them, through the application of economic maintenance equipment in thermal power plants, the actual production and operation costs can be effectively reduced. Based on this, the author will analyze the application of the model of economic maintenance of steam engine professional equipment in thermal power plants.
Design and Research on Identification of Typical Tea Plant Diseases Using Small Sample Learning
Authors: Yang Jian
Published: October 2024

Tea plants are susceptible to diseases during their growth. These diseases seriously affect the yield and quality of tea. The effective prevention and control of diseases requires accurate identification of diseases. With the development of artificial intelligence and computer vision, automatic recognition of plant diseases using image features has become feasible. As the support vector machine (SVM) is suitable for high dimension, high noise, and small sample learning, this paper uses the support vector machine learning method to realize the segmentation of disease spots of diseased tea plants. An improved Conditional Deep Convolutional Generation Adversarial Network with Gradient Penalty (C-DCGAN-GP) was used to expand the segmentation of tea plant spots. Finally, the Visual Geometry Group 16 (VGG16) deep learning classification network was trained by the expanded tea lesion images to realize tea disease recognition.
An Integrated Model of Smart Home Applications User Experience Based on Cognitive Dissonance
Authors: Wang Lili , Mohd Nasir Nadia , Yang Shuang
Published: October 2024

This study constructs an integrated model of user experience in smart home applications (apps) to deeply explore the impact of cognitive dissonance on users’ emotional responses, subsequent behaviors, and experiential outcomes. The research emphasizes the importance of addressing emotional management in the design and development of smart home apps. The findings indicate that emotional response plays a critical mediating role in the user experience of these apps, offering new insights for further optimization. By understanding users’ emotional reactions and behavioral patterns under cognitive dissonance, developers can more effectively improve interface design and enhance the overall user experience.
Intelligent Assisted Travel Wheelchair Based on Image Recognition Technology
Authors: Li Shuai
Published: October 2024

This paper introduces an intelligent image recognition system integrated into a wheelchair based on deep learning in cold environments, aiming to improve the convenience and safety of disabled individuals. The system adopts advanced image recognition technology to monitor road conditions in real-time through the camera and to detect and measure distance to foreign objects on the road. The system visualizes the detection results on the wheelchair screen to assist the user in avoiding and improving the safety of their daily travel. In addition, the system also includes crawler tracks, seat heating, snow and rain protection, and other functions. The wheelchair has a wide range of application prospects and development potential. It is expected to be widely used in the future, providing a strong guarantee for the safe travel of disabled individuals in China.
The Analysis of Factors that Influence Stunting
Authors: Santoso Puguh , Pujianto Tutut
Published: October 2024

Stunting in children is a national problem caused by many factors that harm human resources in the future, including an impact on decreasing intelligence, vulnerability to disease, hampering economic growth, work productivity, exacerbating inequality, and height growth is shorter than age in general. Stunting in children under five is a consequence of several factors that are often associated with poverty, including nutrition, health, sanitation, and the environment There are five main factors that cause stunting, namely poverty, social and cultural, increased exposure to infectious diseases, food insecurity and community access to health service. The purpose of this literature review was to analyze the factors that influence stunting. The article was obtained from a SINTA accredited journal published in the 2013-2023 period with the same title, as well as the same research design. The selected articles were then tested for plagiarism, and nine articles with the smallest plagiarism level were selected. Analysis PICO (Population, Intervention, Comparison, Outcome) is carried out on each article, followed by making conclusions. The results of the analysis determined that factors that influence stunting include social and cultural, increased exposure to infectious diseases, food insecurity and community access to health services alone or together. The author hopes that this research will further greatly help how to do health promotion, case finding and prevention, and, many sectors must be involved and work together for the problem of stunting.
SYSTEMATIC ANALYSIS OF THE CAUSES AND FACTORS OF ADVERSE REACTIONS OF OMALIZUMAB
Authors: K.O. Schneider , M.L. Maksimov , B.K. Romanov
Published: October 2024

The article presents a systematic analysis of the causes and factors of adverse reactions to the use of omalizumab. Methods of monitoring appeals, expert assessment, and interviewing medical specialists were applied. The analysis showed that in Russia there is a "declarative passivity" of medical workers and patients in relation to reports of adverse reactions to the use of omalizumab, which is associated with a high workload and reluctance on the part of medical workers to issue a notification, lack of knowledge about the procedure for notification, fear of being punished for possible incorrect actions on the use of the drug; on the part of patients – by not knowing their rights and the procedure for submitting a report, by fear of spoiling relations with the attending physician. Such passivity and closeness hinders the formation of a system for the prevention of drug safety violations. The data obtained in the course of the study (on the frequency and structure of adverse reactions to the use of omalizumab in clinical practice in children and adults; information on the most dangerous combinations of omalizumab with other drugs; The characteristics of the causes and factors of adverse reactions to the use of omalizumab, as well as the untimely submission of notifications about them, have become the theoretical basis for the development of recommendations for improving pharmacovigilance activities to ensure the safety of the use of omalisamab in children and adults, which includes 4 areas: creation of organizational conditions to ensure the safety of the use of omalisamab in children and adults in medical organizations; prevention of adverse reactions to the use of omalizumab at the preclinical stage; optimization of clinical choice and support for decision-making by a medical specialist (doctor) when prescribing omalizumab based on a risk-based approach, taking into account the individual characteristics of the patient and the clinical situation; improving the quality of safety monitoring of the use of omalizumab.
HR MANAGEMENT AT DIFFERENT STAGES OF DEVELOPMENT OF A PHARMACY ORGANIZATION (REVIEW)
Authors: A.A. Toguzova , Z.S. Tsakhkhaeva , A.A. Shamparova
Published: October 2024

This article discusses the main and most pressing issues related to personnel management at different stages of development of a pharmacy organization. In particular, it talks about the need for constant and effective improvement of personnel management, since, as a rule, the success and profitability of any organization, including a pharmacy, depends on the correct placement of personnel. The article also analyzes the functioning of personnel services at each individual stage of a pharmacy organization and provides recommendations aimed at improving personnel management.
SHORT-STAY INPATIENT - EMPHASIS ON SPINE SURGERY AND PAIN MANAGE-MENT CLINIC
Authors: E.N. Yarygina , V.V. Shkarin , Yu.A. Makedonova , A.G. Pavlova-Adamovich , H.H. Muhaev
Published: October 2024

There are quite a lot of predictor factors for the development of myofascial pain syndrome of the chewing muscles. At the moment, there is no single pathogenetic theory of the development of this pathology. Accordingly, uniform criteria for evaluating the effectiveness of the therapy have not been developed, which was the purpose of this study. The aim of the study is to develop and implement criteria for the effectiveness of treatment of patients with myofascial masticatory muscle pain syndrome. Materials and methods. 45 people with myofascial masticatory muscle pain syndrome were examined and treated. Screening diagnostics of 30 conditionally healthy people was carried out to obtain control values. The study was conducted in three stages – assessment of stress levels according to the data of filling out a questionnaire on the level of susceptibility to stress, clinical examination – determination of qualitative and quantitative criteria, ultrasound and electromyographic examination. Relief of myofascial pain syndrome of the masticatory muscles was performed by injections of botulinum toxin type A into the masticatory and temporal muscles. The dynamics was assessed at the time of 14 days and 1 month. Results. The developed criteria clearly reflect the effectiveness of the therapy. Statistically significant results of the effectiveness of treatment have been obtained, allowing timely optimal therapy and preventing the development of chronic disorders of the temporomandibular joint. Understanding the combined influence of the psychoemotional state and somatic factors led to the development of uniform criteria for the effectiveness of treatment of this category of patients. The analysis and dynamics of changes in qualitative and quantitative indicators reflect the current trend towards the development of minimally invasive approaches to diagnosis and treatment based on the principles of biofeedback, which prevent the chronization of the process and the development of temporomandibular joint dysfunction.
LEAN TECHNOLOGIES IN THE MANAGEMENT SYSTEM AS AN IN-STRUMENT FOR IMPROVING THE EFFICIENCY OF ECONOMIC ACTIVITY OF MEDICAL INSTITUTIONS
Authors: T.A. Sinenko , A.A. Sinenko
Published: October 2024

The solution of efficiency improvement issues is relevant for all types of organizations. The article reveals the features of the category "efficiency" in relation to the essence of the activi-ties of medical organizations, which includes the concepts of not only economic, but also so-cial effect, which significantly expands the boundaries of the economic benefits received. The article discusses the main reasons for the importance of solving the problems of improving the efficiency of organizations in the medical field, namely, regulatory and market. It is proved that the main tool to improve the efficiency of the economic activities of medical insti-tutions are management systems involving the use of lean manufacturing technologies. These technologies make it possible to identify resource losses, at the same time, positively solve the problems of improving the quality of medical services. The author focuses on the fact that in the case of the use of lean technologies, the management system should be formed taking into account the complexity of the nature of medical institutions as an object of management.
THE METHOD OF COMPREHENSIVE ASSESSMENT OF ARTIFICIAL CROWNS IN THE ORAL CAVITY
Authors: E.G. Borisova , M.K. Fedichkina , D.A. Putilin , D.A. Zuev
Published: October 2024

According to statistics collected by domestic and foreign authors, the number of patients in need of orthopedic treatment is increasing every year. [7,8] Modern dental prosthetics includes not only an integrated approach to rehabilitation and restoration of lost functions, but also a high level of aesthetics of the prostheses themselves, which has a significant impact on the comfort and quality of life of dental patients [7,8,15]. The patient's subjective satisfaction with the result of treatment is one of the main tasks of an orthopedic dentist, no less important than rational prosthetics itself. Thus, in order to achieve success, it is necessary to carefully analyze the initial clinical situation, draw up a comprehensive treatment plan, perform dental prosthetics and evaluate the results obtained.
The purpose of the work: to propose a fast and effective method for the comprehensive assessment of an artificial tooth crown, which would have practical application by dentists, would not require significant efforts to interpret the results, and also took into account the general subjective assessment of the patient's quality of life.
We have created a web page on the Internet where the proposed two-stage questionnaire is posted.
The following technologies and libraries were used to implement the project:
HTML5: The main markup language for creating the structure of a web page, including a table with evaluation parameters.
CSS: A style language used for the visual design of a table and other elements of a web page to provide a user-friendly and intuitive interface for users.
JavaScript: A scripting programming language used to implement the logic of calculating the W coefficient and dynamically displaying the results on the page.
The first part is an assessment of artificial crowns according to the method of patent No. 2619386 From the Russian Federation, IPC A61B 10/00 [3], supplemented by an assessment of galvanosis phenomena. The second part is presented by the standardized questionnaire OHIP-14RU [1].
The proposed technique allows for a quick, effective, comprehensive and unified assessment of artificial crowns and their impact on the comfort of the patient's quality of life.
Conclusions. This work is aimed at improving the results of comprehensive orthopedic treatment and rehabilitation of patients. The technique allows for a comprehensive assessment, is fast and effective, and is suitable for direct use at a clinical appointment and in research activities in the field of medicine.
QUALITY OF LIFE AND COGNITIVE IMPAIRMENT IN PATIENTS WITH CHRONIC HEART FAILURE
Authors: Z.H. Zhilokov , N.G. Lozhkina , Kh.M. Bataev
Published: October 2024

Abstract. Вackground. Chronic heart failure (CHF) has a high prevalence in the Russian population. It is one of the main causes of reduced quality of life in cardiology patients due to the gradual progression of the disease and the development of complications, as well as the development of cognitive impairment. Early recognition of these disorders will optimize the management of patients with CHF.
Purpose of the study. To evaluate the quality of life and cognitive functions in patients with different severity of chronic heart failure.
Characterization of patients and methods of the study. 105 patients with confirmed diagnosis of CHF with different functional classes according to NYHA were included in the open cross-sectional non-randomized cohort study. Cognitive screening was performed using the Montreal Cognitive Assessment (MoCA), and quality of life was assessed by the Quality of Life Questionnaire (EQ-5D).
Statistical Analysis Methods. Excel data analysis package and SPSS 23.0 data analysis package were used.
Results and Conclusion. A pilot study was conducted to detect mild or severe cognitive impairment using the Montreal Cognitive Scale and quality of life using the EQ-5D questionnaire in patients with different functional classes of CHF. A significant correlation was found between cognitive function and left ventricular ejection fraction. Quality of life did not depend on the severity of CHF, sex, age, concomitant pathology. The obtained data should be taken into account in personalized management of patients with CHF.
HISTORICAL PREREQUISITES FOR THE FORMATION OF A CULTURE OF ADOLESCENT HEALTH
Authors: N.V. Biryukova
Published: October 2024

The article highlights theoretical approaches to the study of the current task of creating a culture of health among adolescents. Emphasis is placed on the study of the historical roots and sociocultural factors that contributed to the emergence and further development of this issue. The article discusses how the health culture of students was formed in a historical aspect, and also examines the conceptual apparatus, covering two key trajectories of research: firstly, clarification and explanation of the central theme of the work - the culture of student health, and, secondly, the study of the possibilities of using resources educational environment in order to increase the effectiveness of overcoming challenges associated with the protection and promotion of a healthy lifestyle among children and adolescents.
The importance of an integrated approach to the formation of a healthy lifestyle among schoolchildren is emphasized, which should take into account both established traditions and values, and modern trends in the educational sphere. In the context of this study, a detailed analysis and substantiation of the importance of cultivating a culture of health in educational institutions is proposed as one of the determining factors in preparing the younger generation for life in society, focusing on the role of education in developing in schoolchildren and adolescents a conscious approach to their health and the health of others.
POLYEXTRACT OF THE FRUIT OF ZIZIPHUS JUJUBA: STUDY AND STANDARDIZATION
Authors: Y.V. Asaturov , E.V. Borisenko , O.A. Semkina
Published: October 2024

The main quality indicator for polyextracts is the content of biologically active substances (BAS). Depending on the presence of various groups of biologically active substances, the consistency and stability of the extracts, the regulatory documentation for the extracts contains requirements regarding their composition and quality. Liquid extracts are standardized according to the content of ethyl alcohol. Thick and dry extracts are assessed by their moisture content. Heavy metals are determined in all extracts. Standardization of plant extracts is carried out in accordance with the current regulatory documentation, namely the State Pharmacopoeia of the Russian Federation [1-4]. In this study, using the following methods: GC - MS, TLC and UV spectrophotometry, we studied extracts of the fruits of the common jujube Ziziphus Jujuba Mill., obtained by cascade extraction of raw materials with a solvent system with increasing polarity for maximum depletion of raw materials according to the main groups of biologically active substances. As a result of the work, the quality indicators of the polyextract of jujube fruits were determined and the drug was standardized in terms of the content of total flavonoids and total polysaccharides. The work was carried out in accordance with the research topic of the Federal State Budgetary Scientific Institution VILAR FGUU-2022-0011.
EXPERIMENTAL METHODS OF MODELING PREMATURE OVARIAN FAILURE: ADVANTAGES AND DISADVANTAGE
Authors: M.A. Tsarkova , A.V. Fomina
Published: October 2024

Premature ovarian insufficiency (POI) is a disorder of ovarian function in women under 40 years of age accompanied by amenorrhea or oligomenorrhea for more than 4-6 months with biochemical confirmation of follicle-stimulating hormone (FSH) levels >25 IU/L when assessed twice at 4-week intervals. There are four main types of mouse models of PND: the "chemotherapy" model, the "autoimmune" model, the "psychological stress" model, and the "natural aging" model. The most commonly used is the chemotherapeutic model of NPT induced by cyclophosphamide. Also, such a model can be obtained by induction with trypterigium glycosides (TG), busulfan (BF), DOX, etc. An autoimmune model is developed using ZP3 glycoproteins, a stress mouse model of PNJ is obtained using CUMS, MS, etc. methods. By subcutaneous injection of D-Gal, a natural aging model is generated. Each has its own advantages and disadvantages, relative to ideal criteria mouse models of premature ovarian failure. Based on such considerations, chemotherapeutic models are leading so far, but this mode of induction has a number of side effects such as myelosuppression and bleeding. The aim of this review is to analyze the current data on different murine models of PND, their advantages disadvantages, as well as subtypes and modes of induction.