bluuebunny/crossref_metadata_2025 huggingface dataset:
The burden of disease and economic impact of sugar-sweetened beverages’ consumption in Argentina: A modeling study
Authors: Bardach Ariel Esteban , Espínola Natalia , Cairoli Federico Rodríguez , Perelli Lucas , Balan Darío , Palacios Alfredo , Augustovski Federico , Pichón-Riviere Andrés , Alcaraz Andrea Olga
Published: February 2023

Background

Approximately two-thirds of Argentine adults are overweight or obese, and 11% have diabetes. Over the last two decades, all population groups have increased their consumption of ultra-processed foods and sugar-sweetened beverages (SSB). We aimed to estimate the disease burden—deaths, events, and costs to the health system—attributed to SSB consumption in Argentina.

Methods

We used a comparative risk assessment framework to estimate the health and economic impacts that would be avoided in a scenario without sugar-sweetened beverage (SSB) consumption. We calculated the direct effects on diabetes, cardiovascular disease, and BMI, and then estimated the effects of BMI on disease incidence. Finally, we applied the population attributable factor to calculate the health and economic burden avoided in Argentina in 2020.

Results

Our model estimated that about 4,425 deaths, 110,000 healthy life years lost to premature death and disability, more than 520,000 cases of overweight and obesity in adults, and 774,000 in children and adolescents would be attributed to SSB Consumption in Argentina. This disease burden corresponds to 23% of type-2 diabetes cases and other significant proportions of cardiovascular disease and cancer. The overweight and obesity costs attributable to SSB totaled approximately $47 million in adults and $15 million in children and adolescents.

Conclusion

A significant number of disease cases, deaths, and health care costs could be attributed to SSB consumption in Argentina. Implementing measures to reduce the sugar content in beverages is a pending debt for the country and could lead to measurable improvements in population health, especially among children and adolescents.
Prediction of improved antimalarial chemotherapy of artesunate-mefloquine in combination with mefloquine sensitive and resistant Plasmodium falciparum malaria
Authors: Saeheng Teerachat , Na-Bangchang Kesara
Published: February 2023

Background

Declining in susceptibility of Plasmodium falciparum to mefloquine is reported in South-East Asia. A revisiting on mefloquine pharmacokinetics-pharmacodynamics (PK/PD) could assist in finding new appropriate dosage regimens in combination with artesunate as a three-day course treatment.

Objective

This study aimed to investigate promising alternative artesunate-mefloquine combination regimens that are effective for the treatment of patients with mefloquine-sensitive and resistant P. falciparum malaria.

Methods

Data collected during 2008–2009 from 124 patients with uncomplicated P. falciparum malaria were included in the analysis, 90 and 34 patients with sensitive and recrudescence response, respectively. All patients were treated with a three-day combination of artesunate-mefloquine. Population PK-PD models were developed. The developed models were validated with clinically observed data. Simulations of clinical efficacy of alternative mefloquine regimens were performed based on mefloquine sensitivity, patients’ adherence and parasite biomass.

Results

The developed PK/PD models well described with clinically observed data. For mefloquine-resistant P. falciparum, a three-day standard regimen of artesunate-mefloquine is suitable (>50% efficacy) only when the level of parasite sensitivity was < 1.5-fold of the cut-off level (IC50 < 36 nM). For mefloquine-sensitive parasite with IC50 < 23.19 nM (0.96-fold), all regimens provided satisfactory efficacy. In the isolates with IC50 of 24 nM, regimen-I is recommended. Curative treatment criteria for mefloquine and artesunate were C336h (>408 ng.mL-1) or Cmax/IC50 (>130.1 g.m/M), and Cmax/IC50 (>381.2 g.m/M), respectively.

Conclusions

Clinical use of a three-day standard artesunate-mefloquine is suitable only when the IC50 of P. falciparum isolates is lower than 36 nM. Otherwise, other ACT regimens should be replaced. For mefloquine-sensitive parasite, a dose reduction is recommended with the IC50 is lower than 23.19 nM.
Research data management needs assessment for social sciences graduate students: A mixed methods study
Authors: Zhou Xuan , Xu Zhihong , Kogut Ashlynn
Published: February 2023

The complexity and privacy issues inherent in social science research data makes research data management (RDM) an essential skill for future researchers. Data management training has not fully addressed the needs of graduate students in the social sciences. To address this gap, this study used a mixed methods design to investigate the RDM awareness, preparation, confidence, and challenges of social science graduate students. A survey measuring RDM preparedness and training needs was completed by 98 graduate students in a school of education at a research university in the southern United States. Then, interviews exploring data awareness, knowledge of RDM, and challenges related to RDM were conducted with 10 randomly selected graduate students. All participants had low confidence in using RDM, but United States citizens had higher confidence than international graduate students. Most participants were not aware of on-campus RDM services, and were not familiar with data repositories or data sharing. Training needs identified for social science graduate students included support with data documentation and organization when collaborating, using naming procedures to track versions, data analysis using open access software, and data preservation and security. These findings are significant in highlighting the topics to cover in RDM training for social science graduate students. Additionally, RDM confidence and preparation differ between populations so being aware of the backgrounds of students taking the training will be essential for designing student-centered instruction.
Rhodopsin-positive cell production by intravitreal injection of small molecule compounds in mouse models of retinal degeneration
Authors: Fujii Yuya , Arima Mitsuru , Murakami Yusuke , Sonoda Koh-Hei
Published: February 2023

We aimed to verify whether the intravitreal injection of small molecule compounds alone can create photoreceptor cells in mouse models of retinal degeneration. Primary cultured mouse Müller cells were stimulated in vitro with combinations of candidate compounds and the rhodopsin expression was measured on day 7 using polymerase chain reaction and immunostaining. We used 6-week-old N-methyl-N-nitrosourea-treated and 4-week-old rd10 mice as representative in vivo models of retinal degeneration. The optimal combination of compounds selected via in vitro screening was injected into the vitreous and the changes in rhodopsin expression were investigated on day 7 using polymerase chain reaction and immunostaining. The origin of rhodopsin-positive cells was also analyzed via lineage tracing and the recovery of retinal function was assessed using electroretinography. The in vitro mRNA expression of rhodopsin in Müller cells increased 30-fold, and 25% of the Müller cells expressed rhodopsin protein 7 days after stimulation with a combination of 4 compounds: transforming growth factor-β inhibitor, bone morphogenetic protein inhibitor, glycogen synthase kinase 3 inhibitor, and γ-secretase inhibitor. The in vivo rhodopsin mRNA expression and the number of rhodopsin-positive cells in the outer retina were significantly increased on day 7 after the intravitreal injection of these 4 compounds in both N-methyl-N-nitrosourea-treated and rd10 mice. Lineage tracing in td-Tomato mice treated with N-methyl-N-nitrosourea suggested that the rhodopsin-positive cells originated from endogenous Müller cells, accompanied with the recovery of the rhodopsin-derived scotopic function. It was suggested that rhodopsin-positive cells generated by compound stimulation contributes to the recovery of retinal function impaired by degeneration.
Is metformin use associated with low mortality in patients with type 2 diabetes mellitus hospitalized for COVID-19? a multivariable and propensity score-adjusted meta-analysis
Authors: Ma Zhiyuan , Krishnamurthy Mahesh
Published: February 2023

Background

Coronavirus disease 2019 (COVID-19) is a new pandemic that the entire world is facing since December of 2019. Increasing evidence has shown that metformin is linked to favorable outcomes in patients with COVID-19. The aim of this study was to address whether outpatient or inpatient metformin therapy for type 2 diabetes mellitus is associated with low in-hospital mortality in patients hospitalized for COVID-19.

Methods

We searched studies published in PubMed, Embase, Google Scholar and Cochrane Library up to November 1, 2022. Raw event data extracted from individual study were pooled using the Mantel-Haenszel approach. Odds ratio (OR) or hazard ratio (HR) adjusted for covariates that potentially confound the association using multivariable regression or propensity score matching was pooled by the inverse-variance method. Random effect models were applied for meta-analysis due to variance among studies.

Results

Twenty-two retrospective observational studies were selected. The pooled unadjusted OR for outpatient metformin therapy and in-hospital mortality was 0.48 (95% CI, 0.37–0.62) and the pooled OR adjusted with multivariable regression or propensity score matching was 0.71 (95% CI, 0.50–0.99). The pooled unadjusted OR for inpatient metformin therapy and in-hospital mortality was 0.18 (95% CI, 0.10–0.31), whereas the pooled adjusted HR was 1.10 (95% CI, 0.38–3.15).

Conclusions

Our results suggest that there is a significant association between the reduction of in-hospital mortality and outpatient metformin therapy for type 2 diabetes mellitus in patients hospitalized for COVID-19.
Flagella-driven motility is a target of human Paneth cell defensin activity
Authors: Akahoshi Douglas T. , Natwick Dean E. , Yuan Weirong , Lu Wuyuan , Collins Sean R. , Bevins Charles L.
Published: February 2023

In the mammalian intestine, flagellar motility can provide microbes competitive advantage, but also threatens the spatial segregation established by the host at the epithelial surface. Unlike microbicidal defensins, previous studies indicated that the protective activities of human α-defensin 6 (HD6), a peptide secreted by Paneth cells of the small intestine, resides in its remarkable ability to bind microbial surface proteins and self-assemble into protective fibers and nets. Given its ability to bind flagellin, we proposed that HD6 might be an effective inhibitor of bacterial motility. Here, we utilized advanced automated live cell fluorescence imaging to assess the effects of HD6 on actively swimming Salmonella enterica in real time. We found that HD6 was able to effectively restrict flagellar motility of individual bacteria. Flagellin-specific antibody, a classic inhibitor of flagellar motility that utilizes a mechanism of agglutination, lost its activity at low bacterial densities, whereas HD6 activity was not diminished. A single amino acid variant of HD6 that was able to bind flagellin, but not self-assemble, lost ability to inhibit flagellar motility. Together, these results suggest a specialized role of HD6 self-assembly into polymers in targeting and restricting flagellar motility.
‘Costume and Fairy Tales’
Authors: Murai Mayako
Published: February 2023

Costume plays an important part both in traditional fairy tales and in their adaptations in diverse media forms. Clothes worn by characters in fairy tales function according to the internal narrative logic that constitutes and organizes the story-world, defining and transforming the wearers’ identities and social contexts. In this sense, fairy-tale clothes can be regarded as costume, defined as the kind of clothes that bears significance within a staged, performed moment for an audience. The ubiquitous persistence of fairy tales in various media intended for both children and adults renders them a means to express social, cultural and psychological anxieties evoking ethical dimensions of individual and collective struggles. As such, the way characters are embodied through their clothes bears significant narrative and performative potential in layering of meanings in performance making. While the relationship between fashion and the fairy tale has been examined in the fields of fashion studies and fairy-tale criticism, the concept of costume in the fairy tale has not yet been sufficiently explored. This Special Issue on ‘Costume and Fairy Tales’, with its interdisciplinary and cross-cultural approach, offers fresh insight into the fields of costume studies, fairy-tale studies, performance studies, and, more broadly, studies of art, narrative and culture across time, space and discipline.
Scenography and Art History: Performance Design and Visual Culture, Astrid Von Rosen and Viveka Kjellmer (eds) (2021)
Authors: Rewa Natalie
Published: February 2023

Review of: Scenography and Art History: Performance Design and Visual Culture, Astrid Von Rosen and Viveka Kjellmer (eds) (2021)

London: Bloomsbury Visual Arts, 256 pp.,

ISBN 978-1-35020-444-7, h/bk, £85.00
Subcategorization of intermediate suspicion thyroid nodules based on suspicious ultrasonographic findings
Authors: Kim Haejung , Shin Jung Hee , Kim Ka Eun , Kim Myoung Kyoung , Oh Jiyun , Hahn Soo Yeon
Published: February 2023

Purpose: This study compared the malignancy risk of intermediate suspicion thyroid nodules according to the presence of suspicious ultrasonographic (US) findings.Methods: From January 2014 to December 2014, 299 consecutive intermediate suspicion thyroid nodules in 281 patients (mean age, 50.6±12.5 years) with final diagnoses were included in this study. Two radiologists retrospectively reviewed the US findings and subcategorized the intermediate suspicion category into nodules without suspicious findings and nodules with suspicious findings, including punctate echogenic foci, nonparallel orientation, or irregular margins. The malignancy rates were compared between the two subcategory groups.Results: Of the 299 intermediate suspicion thyroid nodules, 230 (76.9%) were subcategorized as nodules without suspicious findings and 69 (23.1%) as nodules with suspicious findings. The total malignancy rate was 33.4% (100/299) and the malignancy rate of nodules with suspicious findings was significantly higher than that of nodules without suspicious findings (47.8% vs. 29.1%, P=0.004). In nodules with suspicious findings, the most common suspicious finding was punctate echogenic foci (48/82, 58.5%) followed by nonparallel orientation (22/82, 26.8%) and irregular margins (12/82, 14.6%). Thirteen nodules had two suspicious findings simultaneously. A linearly increasing trend in the malignancy rate was observed according to the number of suspicious US findings (P for trend=0.001).Conclusion: Intermediate suspicion thyroid nodules with suspicious findings showed a higher malignancy rate than those without suspicious findings. Further management guidelines for nodules with suspicious findings should differ from guidelines for nodules without suspicious findings, even in the same US category.
On Museum Anthropology Review (2007-2023)
Authors: Jackson Jason Baird
Published: February 2023

In an editorial, Museum Anthropology Review editor Jason Baird Jackson discusses the work and circumstances of the journal in the context of it suspending publication with volume 17.
Sustainable Long-Term Energy Supply and Demand: The Gradual Transition to a New and Renewable Energy System in Indonesia by 2050
Authors: Yudiartono Yudiartono , Windarta Jaka , Adiarso Adiarso
Published: February 2023

The objective of this work is to evaluate long-term energy demand and supply decarbonization in Indonesia. On the demand side, electric vehicles and biofuels for transportation and induction stoves and urban gas networks for households were considered. Based on the National Energy Policy, primary energy supply projections optimized NRE power plant use and increase NRE's position in the national energy mix. A Low Emissions Analysis Platform (LEAP) model evaluates 2020–2050 energy demand predictions and low-carbon energy systems. This study's sustainable transition options require two basic technical advances. First, electric vehicles and induction stoves would reduce oil fuel usage by 228.34 million BOE and LPG consumption by 24.65 million BOE. Second, power generation should be decarbonized using NRE sources such as solar, hydro, biomass, geothermal, and nuclear. In 2050, solar power (40 GW), hydropower (38.47 GW), geothermal power (10 GW), and other NRE (24.45 GW, 18.67 GW of which would be biomass power) would dominate NRE electrical capacity. Biomass co-firing for coal power plants would reach 36.35 million tons in 2050. In 2035, the Java-Bali or West Kalimantan system will deploy 1 GW of nuclear power reactors, rising to 4 GW by 2050. Under the Transition Energy (TE) scenario, by 2025 and 2050, new and renewable energy would make up 23% and 31% of the primary energy mix, respectively, reducing GHG emissions per capita. According to predictions, annual GHG emissions per capita will decline from the BAU scenario's 4.48 tonne CO2eq/capita in 2050 to the TE scenario's 4.1 tonne.
Elevated Hemolysis Index is associated with higher risk of cardiovascular diseases
Authors: Gils Charlotte , Hansen Dennis Lund , Nybo Mads , Frederiksen Henrik
Published: February 2023

Objectives

In vivo hemolysis is associated with thromboembolism. Although an increased Hemolysis Index (HI) can be due to in vitro as well as in vivo hemolysis, both reflects a more fragile erythrocyte population. We therefore hypothesized that HI above upper reference limit would be associated with an increased risk of cardiovascular disease (CVD).

Methods

We identified persons with two elevated HI (HI+) from blood samples analyzed at a university hospital laboratory from 2012 to 2017. We compared their risk of CVD with the risk in matched comparators with normal HI and from the general population. HI+ persons and comparators were followed from start date (date of the second elevated HI) until the first of the main outcome: CVD, emigration, death, or end of observation time on December 31, 2018.

Results

In 43,102 unique HI+ persons, the risk of developing CVD was 40% higher compared with the general population and 13% higher compared with the matched blood sample cohort. HI+ was associated with a significantly increased cumulative incidence of both arterial and venous CVD compared with the matched blood sample cohort and the general population (respectively 47 and 14% for arterial CVD; 78 and 24% for venous CVD). Moreover, overall mortality risk was significantly higher in patients with HI+ than in the two comparator groups.

Conclusions

Elevated HI is associated with increased risk of arterial and venous CVD and with increased mortality. Our findings imply that HI may contribute as a CVD risk biomarker.
Evaluation of a rough-surface evaporator applied to an absorption heat transformer for water desalination
Authors: Romero David Juárez , Rivera Irán Ortiz , Canela Sánchez Isaac Justine , Ortega Mojica Nancy Isamar , Huicochea Armando , Gonzaga Javier Delgado
Published: February 2023

The purpose of this work is to evaluate the performance of a rough-textured evaporator applied to a single-stage absorption heat transformer for water desalination (SAHT-WD). The stainless-steel evaporator was subjected to an abrasive material release treatment (sandblast texture) to provide a texture that fosters phase change heat transfer compared to a smooth surface. To determine the performance of the evaporator, the evaluation has been divided into an experimental and a theoretical analysis. The experimental analysis focused on determining the operating conditions that favor the performance of the evaporator and the SAHT-WD. For the theoretical analysis, a mathematical model was developed to predict the wetting efficiency and the heat-transfer coefficients of the evaporator. To quantify the improvement in the performance of the rough-surface evaporator, the experimental results were compared with those reported in a reference work. The results indicate that the sandblasted texture improved the performance of the evaporator as well as that of the SAHT-WD. The results of the mathematical model suggest that the rough tube improved the wetting efficiency of the evaporator.
Food or rut: contrasting seasonal patterns in fat deposition between males and females of northern and southern sika deer populations in Japan
Authors: Takatsuki Seiki , Hosoi Eiji , Tado Hiroyuki
Published: February 2023

Overwintering is important for the survival of northern mammals, and northern ungulates deposit body fat. Researchers have interpreted fat deposition as an adaptation to food shortages during winter. However, it is likely that reproductive activities also affect fat deposition. We compared kidney fat indices (KFIs) of sika deer (Cervus nippon) between the northern and southern populations in Japan. In the northern population, the KFIs of adult males and females peaked during summer and autumn, respectively. In adult males, the KFIs abruptly declined during the rut (October), while in yearling males and fawns, they were low in summer. In the southern population, KFIs of adult males were high in summer but decreased in October. KFIs of adult females were low and increased in December–January. KFIs of fawns were low. These results suggest that most classes of the southern population did not deposit much fat during the summer except for adult males. The result that southern adult males displayed as much fat deposition as the northern males suggests that body fat was deposited not only for overwintering but also for reproductive activity of adult males.
Wide field of view and full Stokes polarization imaging using metasurfaces inspired by the stomatopod eye
Authors: Liu Jianying , Chu Jinkui , Zhang Ran , Liu Rui , Fu Jiaxin
Published: February 2023

Wide field of view and polarization imaging capabilities are crucial for implementation of advanced imaging devices. However, there are still great challenges in the integration of such optical systems. Here, we report a bionic compound eye metasurface that can realize full Stokes polarization imaging in a wide field of view. The bionic compound eye metasurface consists of a bifocal metalens array in which every three bifocal metalenses form a subeye. The phase of the bifocal metalens is composed of gradient phase and hyperbolic phase. Numerical simulations show that the bifocal metalens can not only improve the focusing efficiency in the oblique light but also correct the aberration caused by the oblique incident light. And the field of view of the bionic compound eye metasurface can reach 120° × 120°. We fabricated a bionic compound eye metasurface which consists of three subeyes. Experiments show that the bionic compound eye metasurface can perform near diffraction-limited polarization focusing and imaging in a large field of view. The design method is generic and can be used to design metasurfaces with different materials and wavelengths. It has great potential in the field of robot polarization vision and polarization detection.
High-sensitivity polarization-independent terahertz Taichi-like micro-ring sensors based on toroidal dipole resonance for concentration detection of Aβ protein
Authors: Liu Wencan , Zhou Xinwei , Zou Shucai , Hu Zhengguang , Shen Yun , Cai Mengqiang , Lin Dongdong , Zhou Jia , Deng Xiaohua , Guo Tianjing , Lei Jiangtao
Published: February 2023

Terahertz (THz) metamaterial sensor is a newly-developing interdisciplinary technology, which combines the essential characteristics of THz spectroscopy and metamaterials, to obtain better sensitivity for trace detection of the different target analytes. Toroidal dipole resonances show great sensing potential due to their suppression of the radiative loss channel. Here, we found a high-quality planar toroidal dipole resonance in the breaking Chinese Taichi-like ring and then designed a novel polarization-independent terahertz toroidal sensor by combining four Taichi-like rings into a cycle unit. The sensor shows high-sensitivity sensing characteristics for the ultrathin analyte and refractive index. The optimized sensitivity of pure analytes under 4 μm coating thickness can numerically reach 258 GHz/RIU in the corresponding ∼1.345 THz frequency domain, which is much higher than that of previously reported sensors. We further fabricated experimentally the sensor and demonstrated its fascinating polarization-independent characteristics. Finally, it was successfully applied to the low-concentration detection (ranging from 0.0001 mg/mL to 10 mg/mL) of Aβ protein associated with Alzheimer’s disease. Our high-sensitivity polarization-independent THz toroidal dipole sensor would give access to rich applications in label-free biosensing.
Synthesis and crystal structure of (4aR,7S)-7-hydroxy-7-isopropyl-1,1-dimethyldecahydro-2H,6H-8a,4a-(epoxymethano)phenanthren-12-one, C20H32O3
Authors: Chen Ren-Song , Zhang Jing-Jie , Zhang Yi , Xu Chuan-Yan , Ye Jiang-Hai
Published: February 2023

C20H32O3, monoclinic, P21 (no. 4), a = 7.8981(17) Å, b = 10.302(2) Å, c = 11.028(3) Å, β = 90.020(2)°, V = 897.3(3) Å3, Z = 2, R

gt
(F) = 0.0603, wR

ref
(F
2) = 0.1342, T = 273(2) K.
Ultrasonic longitudinal torsion-assisted biotic bone drilling: An experimental study
Authors: Li Zhenhao , Yang Zhibo , Wang Wei , Guo Qiang , Sun Wang , Han Daocheng , Liu Xiaoning , Zhang Yanru
Published: February 2023

State-of-the-art treatment of such orthopedic diseases as fracture and femoral head necrosis implies the installation of prosthesis or fixed equipment into patients’ injured parts using bone drilling. This study proposes an ultrasonic longitudinal torsion-assisted drilling (ULTAD) technique for biotic bone drilling. A comparative experiment was carried out between conventional drilling and ULTAD drilling in biotic bone, namely porcine femur. These tests proved that under the same drilling parameters, the ultrasonic component in bone drilling could reduce the drilling temperature and forces, improve the material removal by chip breaking, shorten the length of bone debris, and facilitate their discharge. Moreover, the proposed ULTAD technique reduced the number, length, and width of microcracks in the borehole wall, thus protecting the drilled biotic bone from internal damage.
Common fixed-point theorems for non-linear non-self contractive mappings in convex metric spaces
Authors: Kumar Santosh , Aron David
Published: February 2023

In this article, two pairs of non-self mappings satisfying a collection of non-linear contractive conditions in convex metric space are considered to prove a common fixed-point theorem. An appropriate example is provided to support the results proved herein. In addition, we have proved a theorem as an application of our main result. Our results generalize and extend several existing theorems in the literature.
Textiles, basketry and cordage from the Early Neolithic settlement of La Marmotta, Lazio
Authors: Mineo Mario , Mazzucco Niccolò , Rottoli Mauro , Remolins Gerard , Caruso-Ferme Laura , Gibaja Juan F.
Published: February 2023

Archaeological investigation of Circum-Alpine lake, or pile, dwellings has afforded unprecedented insight into Neolithic and Bronze Age societies. The discovery in 1989 of a submerged settlement near Rome added an early (eighth millennium BP) geographical outlier to this distribution. Two decades of excavation at La Marmotta have identified more than a dozen dwellings and an enormous assemblage of organic remains. Here, the authors present an overview of the textiles, basketry and cordage recovered, and the tools used to manufacture them. The assemblage paints a more complete picture of the technological expertise of Neolithic societies and their ability to exploit and process plant materials to produce a wide range of crafts.
Movimento e Ação
Authors: Do Nascimento Morais Laura
Published: February 2023

O presente artigo busca compreender o funcionamento da Ação Libertadora Nacional e do Movimiento de Izquierda Revolucionaria, duas instituições de esquerda armada que tiveram uma atuação ativa durante a ditadura civil-militar em seus respectivos países. Ao utilizar da metodologia da História Comparada, busca-se analisar as semelhanças e diferenças de duas das mais importantes organizações de luta armada dentro da América Latina como uma forma de entender suas particularidades.
UNIDADE CUIDATIVA
Authors: Carriconde Fripp Julieta , Da Fonseca Sanghi Simone , Hartmann Buss Izabel
Published: February 2023

A pandemia causada pelo novo coronavírus (COVID-19) tornou-se um dos grandes desafios do século XXI, configurando-se como um sério problema de saúde pública e requerendo ações para seu enfrentamento. De acordo com a Organização Mundial de Saúde (OMS), a pandemia já atingiu mais de 117 países pelo mundo com impactos ainda inestimáveis  que afetam direta e/ou indiretamente a saúde e a economia da população mundial. Nesse sentido, este artigo pauta-se por ações de extensão que foram construídas com o objetivo de trabalhar, inicialmente, questões de prevenção e educação em saúde e, depois, fazer intervenções de cuidados, desde a reabilitação física aos aspectos psicossociais para pacientes que apresentaram sequelas da síndrome Pós COVID, em um Ambulatório de Cuidados Paliativos da Universidade Federal de Pelotas no RS. As ações focaram,  inicialmente, a conscientização da população quanto ao uso de máscaras, confecção e distribuição das mesmas, gratuitamente, aos setores mais vulneráveis da cidade. Tudo isso contando com o envolvimento de pacientes, familiares e voluntários para minimizar o contágio e, consequentemente, contribuir para o achatamento da curva de contaminação populacional. Na sequência, foram realizadas ações para intervir em problemas de ordem física, psicossocial, ocupacional e espiritual em   pessoas que foram acometidas pelo SARS-Cov- 2 com formas moderada e grave, egressos ou não de internação hospitalar pós covid. Dessa forma, essas ações vêm contribuindo de forma sequencial para o enfrentamento dessa pandemia, desde a prevenção até o processo de reabilitação.
EDUCAÇÃO INTERPROFISSIONAL E O USO DAS TICS, REDES SOCIAIS E PORTFÓLIOS NO CONTEXTO DA PANDEMIA PELO COVID-19
Authors: Fin Motta Roberta , Da Silva Meneses Amanda , Gabriele Silva da Silva Julie , Aguiar Lemos Eduarda , Souza da Silva Gabriela , Greggio Samuel
Published: February 2023

O objetivo deste trabalho é relatar a experiência realizada pelo subgrupo “Atenção à Saúde Mental” no projeto “PET-Saúde Interprofissionalidade” (2019-2021), na construção e desenvolvimento de ações extensionistas inovadoras durante a pandemia da COVID-19. O Programa de Educação pelo Trabalho para a Saúde (PET-Saúde) foi criado pelo Ministério da Saúde (MS), envolvendo preceptores, vinculados à Secretaria Municipal de Saúde de Porto Alegre (RS), docentes/tutores e estudantes/bolsistas de Escolas da Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS). Dentre as diversas atividades propostas e metodologias inovadoras realizadas pelo grupo, foi a construção do aprendizado junto à coordenação, à tutoria e à preceptoria que fizeram com que o projeto colocasse em prática o trabalho colaborativo em saúde. Concluímos que foi possível aplicar a interprofissionalidade na prática, enfatizando as estratégias utilizadas para ações de inovação social através dos portfólios, redes sociais e Tecnologias da Informação e Comunicação (TICs).
INOVAÇÃO NA “SALA DE AULA” DA UNIVERSIDADE ABERTA PARA IDOSOS
Authors: Schüler Cavalli Adriana , Laura Hennicka Ana , Segú Copello Fabiola , Gabrielle da Silva Reis Millen , Olivera Cavalli Marcelo
Published: February 2023

A pandemia do COVID-19 mudou o cenário mundial e incentivou o uso das tecnologias digitais em ambientes educacionais e de interação social. Os idosos do programa estratégico da Universidade Aberta Para Idosos da UFPel tiveram que se reinventar e se adaptar ao estilo de aulas no modo remoto. Este estudo descritivo tem o objetivo de determinar a percepção subjetiva dos idosos neste novo formato de aulas não presenciais. Dos trinta e sete idosos participantes em dois cursos de atualização ofertados em 2021, vinte e dois deles responderam ao questionário no Google Forms. O uso do celular foi predominante no atendimento das palestras (90,9%), e mais da metade da amostra (59,5%) relatou ter considerado fácil o acesso às mesmas. Faz-se necessário ponderar que 72% dos idosos indicaram ter participação prévia em outros tipos de aulas pela Internet. Entretanto, 50% dos idosos afirmaram ter tido dificuldades no acesso às palestras por problemas de conexão da internet; por não ouvir direito as falas; e/ou não conseguir participar das discussões em grupo. As palestras de forma não presencial, apesar de terem sido um desafio para muitos dos idosos, trouxeram um pouco de acolhimento neste período de incertezas e ansiedades por meio da aproximação com seus pares e professores, mesmo que de forma remota. Os idosos demonstraram interesse e satisfação neste novo formato de ensino.
SKETCHES URBANOS EM PEQUENAS CIDADES NO NORDESTE BRASILEIRO
Authors: Gomes Machado Eduardo , Dias André , Valdelia Carlos Chagas de Freitas Maria , Maria Francolino da Silva Stefania , Anne Souza da Silva Geyse
Published: February 2023

Esta memória visual apresenta oito sketches urbanos produzidos por André Dias, artista visual cearense, em parceria com grupo de extensão e pesquisa situado na Universidade da Integração Internacional da Lusofonia Afro-Brasileira (UNILAB). Apresentamos oito sketches urbanos que registram duas pequenas cidades interioranas do Nordeste brasileiro, Redenção e Acarape, no Ceará. Os sketches retratam cenas ou situações cotidianas dos espaços urbanos, através de desenhos que articulam diferentes técnicas, materiais e suportes. Os sketches farão parte de uma exposição itinerante que circulará por espaços públicos e escolas das duas cidades, objeti- vando a efetivação de aprendizagem, a construção de diálogos, a valorização de conhecimentos e potenciais efeitos na produção social do espaço urbano. Essa experiência entrelaça ações de extensão e de pesquisa realizadas em duas pequenas cidades, impactadas pela implantação de uma universidade federal pública interiorizada e internacionalizada a partir de 2011. Interessam-nos os lugares, as situações e as dinâmicas urbanas cotidianas, considerando uma diversidade de agentes que, convivendo reiteradamente, ocupam, usam e produzem as cidades. Com destaque para as juventudes estudantis urbanas, com grande parcela delas sendo originária de outras localidades, municípios e países, buscamos perceber como vivenciam e lidam com os desafios cotidianos enfrentados nos espaços urbanos. A metodologia, envolvendo pré-produção, produ- ção e pós-produção, será detalhada no texto.
A IDENTIDADE EM DIÁLOGO COM AS DESIGUALDADES NO CONTESTADO
Authors: Do Nascimento Eduardo
Published: February 2023

As desigualdades estão relacionadas aos processos históricos de organização social e encontram-se nas diferenças entre as posições da estrutura de uma sociedade. Diferenças sobre as quais a justiça é reivindicada. A identidade é o que conecta o sujeito à estrutura social a qual ele pertence. Ela estabiliza tanto os indivíduos quanto os mundos que eles habitam, tornando ambos reciprocamente integrados. Contudo, na atual sociedade há um deslocamento de forma generalizada entre os processos de identificação e articulação comunal. Os dados socioeconômicos mostram que a região do Contestado, localizada geograficamente na região central do estado de Santa Catarina, apresenta as mais acentuadas desigualdades, sendo o maior bolsão de pobreza do estado de Santa Catarina. Apesar de existir uma enorme riqueza de elementos simbólicos de memória no Contestado, a identidade hegemônica de um modelo europeizado de exploração exclui grupos significativos da população. Assim, tem-se como objetivo compreender a relação entre o fortalecimento da identidade coletiva do Contestado e a redução das desigualdades. Foram produzidos seis documentários com foco na identidade do Contestado. Destaca-se nos documentários como os indivíduos se fortalecem enquanto coletivo, apesar das dificuldades enfrentadas. Também se observa um lugar de fala que supõe uma interposição identitária. As produções culturais demonstram um esforço para quebrar com o tensionamento entre a oposição das identidades dominante e de resistência em transformação da sociedade local. Desta forma, observa-se uma construção identitária de transformação, em alinhamento com movimentos sociais contemporâneos como o feminismo e o ambientalismo. A transformação dos valores dominantes pela valorização da cultura cabocla no Contestado é fundamental para uma condição social que permita a recuperação do ambiente e da equidade.
VISÕES DO RURAL
Authors: Rodrigues de Rodrigues Guilherme , Tomaz do Amaral Ribeiro Renata , Alves Trajano Janice , Menasche Renata
Published: February 2023

Este relato busca refletir a respeito de experiência de curricularização da extensão, ocorrida a partir da disciplina Antropologia Rural, oferecida em modalidade de ensino remoto, durante o primeiro semestre de 2021, pelo Curso de Bacharelado em Antropologia da Universidade Federal de Pelotas – UFPel, em parceria com a Escola Família Agrícola da Região Sul – EFASUL. Em tempos de pandemia, a ação extensionista promoveu oficinas sobre técnicas de produção de imagem e vídeo, junto a discentes da EFASUL e da UFPel. O trabalho resultou na elaboração conjunta de uma exposição imagética referente a visões do rural, sediada no site do Museu Histórico da Bibliotheca Pública Pelotense.
IMAGENS EM AÇÃO NA DANÇA E NA EXTENSÃO UNIVERSITÁRIA EM DIAMANTINA-MG
Authors: Regina de Fátima Cíntia , Alves Pereira Marques Danieli , De Oliveira Santos Gilbert , Rocha Andrade Jhonathan , Pereira da Silva Gonçalves Jessé
Published: February 2023

O objetivo deste trabalho é apresentar as memórias visuais do projeto poéticas do corpo, uma ação de extensão e cultura universitária em Diamantina-MG. As imagens, conectando-se às reflexões sobre dança e ensino desenvolvidas, oferecem ao leitor outra possibilidade de acesso às experiências corporais, realçando, sobretudo, a camada da dimensão sensível do gesto. Almejando vivenciar a dança na perspectiva da linguagem, o projeto fundamentou-se, especialmente, nos princípios de Laban, a partir dos estudos de Marques (2010). Os registros comunicam sobre o processo pedagógico, conduzido com ênfase na dimensão da pesquisa gestual, considerando as qualidades expressivas do movimento e a relação do corpo com o espaço. Ao possibilitar o conhecimento a esse acervo, de caráter artístico, também se tem a intenção de sensibilizar o leitor através da contemplação, que pode despertar inúmeras sensações, emoções e percepções individuais. Reflexões sobre os processos criativos em dança e propostas artísticas contemporâneas que inspiraram as práticas de ensino do projeto sustentam as discussões deste ensaio. Enfatiza-se a importância das ações extensionistas nas universidades, assim como a necessidade de espaços em que tais experiências possam ser compartilhadas e valorizadas no meio científico.
PARALIMPÍADAS UNIVERSITÁRIAS
Authors: Denardin Cardoso Vinícius , Barbosa Seron Bruna , Portilho Nicoletti Lucas
Published: February 2023

As Paralimpíadas Universitárias são uma competição que busca estimular a participação dos acadêmicos com deficiência de Instituições de Ensino Superior em modalidades esportivas,utilizando o esporte como ferramenta de integração. Este estudo tem objetivo de ampliar o debate e discussões sobre as Paralimpíadas Universitárias. Trata-se de um estudo com abordagem qualitativa e procedimentos descritivos e exploratórios. Através da reflexão teórica com a literatura, buscamos trazer discussões e considerações. As principais contribuições dessa competição identificadas na literatura nos remetem a: 1) Continuidade nos estudos. A competição favorece e estimula o ingresso de alunos com deficiência na Educação Superior; 2) Visibilidade das pessoas com deficiência. Essa competição esportiva contribui para ampliar a visibilidade da pessoa com deficiência na sociedade; e ainda, 3) Revelação de talentos esportivos. Trata-se de uma forma positiva para identificar novas gerações de atletas para o esporte paralímpico. Dessa forma, concluímos que ao ampliar as oportunidades esportivas para pessoas com deficiência em nível escolar, pode ser possível aprimorar o processo de desenvolvimento de novas gerações de atletas paralímpicos no Brasil e, também, pode contribuir para a formação acadêmica de pessoas com deficiência e a sua visibilidade na sociedade.
Bandgap tuning of optical and electrical properties of zinc selenide
Authors:   Department of Physics, Vivekananda Global University, Jaipur-303012, Rajasthan(India)., Sharma Y. C. , Ansaria P. ,   Department of Physics, Vivekananda Global University, Jaipur-303012, Rajasthan(India)., Sharma R. ,   Department of Electronics and Communication Engineering, Vivekananda Institute of Technology, Jaipur-303012, Rajasthan(India)., Mathur D. ,   Department of Electronics and Communication Engineering, Rajasthan Technical University, Rawatbhata Road, Kota-324010, Rajasthan(India)., Dard R. A. ,   Department of Chemistry, Maharashtra College of Arts, Science and Commerce-Mumbai-400008, Maharashtra (India)
Published: February 2023

Zinc Selenide (ZnSe) as an important II-VI semiconductor and one of the first semiconductors discovered with a band gap of around 2.7 eV at 25 °C. ZnSe thin films have been deposited by e-beam evaporation method with different thicknesses from 50 nm to 150 nm and effects of annealing temperature on optical and electrical properties of thin films have been investigated at room temperature (RT), 1000C and 2000C. It has been found that the energy bandgap of semiconductor thin films tend to decrease as the temperature increases. Optical properties of the synthesized films were investigated by UV-VIS spectrometer in the wavelength range of 400-1000 nm. Energy band gap of films were calculated and variation due to variation in the thickness were observed. The least band gap value was found to be 1.92 eV for 150 nm thin at 2000C.The band gap results show the semiconducting nature of films grown. XRD technique was used to study the structural properties and the Hall measurement and I-V characteristics were used to study the electrical properties of the thin films. Hall characteristic of the ZnSe thin films for 150 nm at room temperature show that the material has p-type semiconducting nature which remains same if annealed to 2000C.
Effect of substrate temperature on the structural, optical and electrical properties of Tin Oxide thin films
Authors:   Department of Physcis, Adhiyamaan College of Engineering (Autonomous), Hosur-635 109, Tamilnadu, India, Jayaprakash R. N. , Mariappan R. ,   Department of Physcis, Adhiyamaan College of Engineering (Autonomous), Hosur-635 109, Tamilnadu, India
Published: February 2023

Interesting semiconductor materials of SnO2 thin films were deposited on the glass substrates heated at different temperatures from 300 to 450oC. The structural, surface morphological, composition, optical and electrical properties of SnO2 thin films were investigated. X-ray diffraction showed that the obtained films were polycrystalline nature with cubic structure and were preferential oriented along the (100) direction. The surface morphology of the films was found to increase in size when the temperature is increased from 300 to 450oC. The composition of these films was also confirmed by energy dispersive analysis by X-ray. Optical properties of the films showed high transmittance maximum at 450 nm for each spectrum is observed as about 82, 86, 87 and 89% respectively. Optical band gap energy was found to be increases from 3.52 to 3.65 nm for the SnO2 films heated from 300 to 450oC. On the other hand, PL spectra of all films with a very sharp peak below 462 nm due to the presence of interstitial oxygen vacancies. Thus, the deposited material shows a potential application in SnO2 thin films and might be useful for gas sensor applications.
Protein complexes in cells by AI‐assisted structural proteomics
Authors: O'Reilly Francis J , Graziadei Andrea , Forbrig Christian , Bremenkamp Rica , Charles Kristine , Lenz Swantje , Elfmann Christoph , Fischer Lutz , Stülke Jörg , Rappsilber Juri
Published: February 2023

Accurately modeling the structures of proteins and their complexes using artificial intelligence is revolutionizing molecular biology. Experimental data enable a candidate‐based approach to systematically model novel protein assemblies. Here, we use a combination of in‐cell crosslinking mass spectrometry and co‐fractionation mass spectrometry (CoFrac‐MS) to identify protein–protein interactions in the model Gram‐positive bacterium Bacillus subtilis. We show that crosslinking interactions prior to cell lysis reveals protein interactions that are often lost upon cell lysis. We predict the structures of these protein interactions and others in the SubtiWiki database with AlphaFold‐Multimer and, after controlling for the false‐positive rate of the predictions, we propose novel structural models of 153 dimeric and 14 trimeric protein assemblies. Crosslinking MS data independently validates the AlphaFold predictions and scoring. We report and validate novel interactors of central cellular machineries that include the ribosome, RNA polymerase, and pyruvate dehydrogenase, assigning function to several uncharacterized proteins. Our approach uncovers protein–protein interactions inside intact cells, provides structural insight into their interaction interfaces, and is applicable to genetically intractable organisms, including pathogenic bacteria.
Effect of Group Counseling on Depression, Stress, and Anxiety of Premenstrual Syndrome: A Randomized Clinical Trial
Authors: Fooladiha Farnaz , Mirzadeh Monir Sadat , Sarraf Maryam , Jourabchi Zinat
Published: February 2023

Objectives: Premenstrual syndrome (PMS) is a combination of physical, spiritual, and emotional symptoms, which periodically happens before the cycle. The current research aims to investigate the effect of group counseling on depression, stress, and anxiety of PMS. Materials and Methods: The current study is a randomized clinical control trial on 112 married women who experience PMS that makes them refer to health centers in Qazvin city. The samples were divided into two groups of 55 in control and 57 in the trial group, randomly. Three sessions of group counseling were held for the trial group, each session was 45 minutes long and including teaching about PMS and its symptoms, depression, stress, and anxiety caused by this syndrome, and also negative mood and stress management skills. Data were gathered by demographic information questionnaire, Depression, Anxiety and Stress Scales 21, and PMS scale. Results: Initially, when starting the study, the results of the studied variables were homogeneous in both intervention and control groups. Moreover, no significant difference was seen in the severity level of PMS symptoms (P=0.70) and depression (P=0.61), stress (P=0.10), and anxiety (P=0.60) score before intervention in both groups. After intervention, the mean scores of severity of the PMS (P<0.001), depression (P<0.001), stress (P<0.001), and anxiety (P<0.001) in the intervention group significantly decreased. Conclusions: Group counseling caused a significant reduction in the severity of PMSs and depression, stress, and anxiety. Counseling protocol for reducing the severity of the PMS and treating depression recommended.