bluuebunny/crossref_metadata_2025 huggingface dataset:
LOSSES OF ELECTRIC ENERGY IN THE ENERGY SYSTEM OF UKRAINE AND THEIR REDUCTION DUE TO THE INTRODUCTION OF DIRECT CURRENT
Authors: Grib Oleg , Karpaliuk Igor , Shvets Sergey , Donetska Tetiana , Diachenko Oleksandr
Published: November 2023

The issue of losses of electrical energy in the energy system of Ukraine is considered. Tendencies of changes in the value of losses in the direction of growth in recent years are shown. Such an increase in losses led not only to the fixation of purely technical parameters, but also led to financial losses in the country and consumers in the amount of tens of billions of hryvnias. Statistical data on global losses of electrical energy are shown, showing a global trend in reducing the magnitude of losses. The trend to reduce losses is being implemented by all developed countries. Data on electricity losses correlate with the economic development of the country. Significant losses are a sign of negative phenomena in the economy, and vice versa, smalllosses are a sign of a stable economic condition. The structure of losses was analyzed. A general representation of losses has been proposed, which has received a graphical representation in the form of a diagram, where two types of electrical energy losses are considered: technological and commercial. Such a division into groups of losses made it possible to separate the analyzed parts. It is precisely those types of losses that are least affected by extraneous human impact, such as theft, destruction of equipment, non-payments, etc., are considered. The nature of such influences is not technical, so they were not considered. A parallel is drawn between the level of equipment wear and the level of electricity losses. A logical chain is shown, in order to reduce losses it is necessary to upgrade the equipment. The energy system includes different elements and is very branched. It can be measured not only by a significant number of equipment items, but also by the cost of these items. The total cost of the energy system is very significant, and it is only possible to carry out energy re-equipment in stages. It is proposed to identify the elements of the energy system that are most sensitive in terms of their impact on losses, for which it would be logical to carry out rearmament in the first place. However, based on international experience, it was proposed that when planning the restoration of the power system, immediately take the most promising direction, namely, not the usual re-equipment of networks through the installation of newer equipment, but to take a qualitative step towards introducing a DC system in lowvoltage networks up to 10 kV inclusive. Which, according to the studies of European scientists, will significantly reduce losses, increase the controllability of networks, and improve the quality of electrical energy.
Aprovechamiento educativo de la conectividad en infancia y adolescencia: una revisión de literatura
Authors: Buenestado-Fernández Mariana , García-Ruiz Rosa , Jiménez-Iglesias Estefanía , Jorge Ana
Published: November 2023

La conexión a internet durante la infancia y la adolescencia conlleva riesgos y oportunidades en diversos ámbitos vitales. Concretamente, este trabajo se centra en identificar líneas de investigación e intervención para un aprovechamiento de la conectividad digital de los menores en el contexto educativo. Para ello se plantea una revisión sistemática de la literatura basada en el método PRISMA y en las bases de datos Web of Science y Scopus para la búsqueda y la selección de artículos. Este estudio se centra en cinco ámbitos clave: evolución temporal, metodología de la investigación, hallazgos obtenidos, implicaciones para la investigación y  práctica educativa, y líneas futuras de investigación. De los 68 trabajos analizados, se observa que: (1) han incrementado su publicación recientemente; (2) predominan los enfoques cualitativos, evaluando los efectos de las intervenciones educativas, principalmente en infantes y jóvenes de Europa y de los niveles de Educación Primaria y Secundaria; (3) se concluye que los entornos donde la conectividad digital de los infantes ha tenido un impacto positivo incluyen mejora del aprendizaje y rendimiento académico, inclusión y accesibilidad digital, creación y producción digital, aprendizaje colaborativo y educación mediática y digital; (4) se sugiere fomentar la educación en alfabetización mediática y competencia digital desde temprana edad para prevenir riesgos y aprovechar oportunidades; y, (5) se alienta a explorar nuevas áreas para optimizar el uso de la conectividad digital entre los infantes. Esta revisión revela las áreas donde la conectividad digital ha tenido un impacto positivo en la educación de los menores.
Hasan Langgulung Thought on Islamic Education
Authors: Musyafaah Nurul
Published: November 2023

Hasan Langgulung is a thinker who is quite influential and has contributed significantly to the development of Islamic education in Indonesia and outside Indonesia. He is one of the thinkers of contemporary Islamic education, where he has contributed ideas that have been contained in several books that are thick with the study of Islamic education. Langulung thought has an exciting style and characteristic to study, especially about the development of Islamic education felt, by reviewing several aspects of its field of expertise, namely education, psychology, language, history, and philosophy. The purpose of this study 1) To determine the concept of Islamic education thought according to Hasan Langgulung. 2) To determine the implementation of Hasan Langgulung's Islamic educational thought in Indonesia. This study uses a qualitative approach. Data collection was done by interview, observation and documentation. Data analysis was done through data reduction, data presentation and conclusion drawing. The results of this study indicate that 1) the thought of Islamic education, according to Langgulung, emphasises the word at-trading, namely, educating humans. The education process should pay attention to the basics of humanity, consider students intelligent creatures of God, and have the right to receive an education. Respect, love and guidance. 2) According to Hasan Langgulung, the Islamization of science must be carried out due to several factors that cannot be avoided, first, the current globalisation, which emphasises science and technology; second, the science of the Qur'an explains a lot about science; this is efforts to prove that all knowledge comes from the Qur'an and hadith.
New distribution record of Nicobar rustic, Cupha erymanthis nicobarica Felder (Lepidoptera: Nymphalidae) from northern India and its biology on newly recorded host plant, Populus deltoides Bartr. ex Marsh.
Authors: Kumar Arvind , Tonk Tripti
Published: November 2023

Populus deltoides, commonly known as poplar, has gained immense significance in the domain of agro-forestry due to its versatile applications. Consequently, farmers in Northern India have increasingly adopted its cultivation. However, poplars worldwide, including India, face a serious challenge in the form of infestations by insect pests. The spectrum of insect pests affecting poplar encompasses various species reported from India. The present study was undertaken at Forest Entomology Division, Forest Research Institute, Dehradun, Uttarakhand, India. The study revealed that leaf defoliator named Cupha erymanthis nicobarica Felder was identified on P. deltoides for the first time in India. This is the first record of C. erymanthis nicobarica from northern region of the country. The observations revealed that the presence of this insect was recorded between April and July. This species complete its biology into 28 to 31 days at 27 ± 0.5ºC and 70 ± 5% RH on P. deltoides leaves. The research delved into studying the biology, seasonal occurrence, and the nature of damage caused by this particular insect pest on poplar trees for the first time in India.
Water’s path from moss to soil Vol. 2: How soil-moss combinations affect the soil water balance and soil erosion
Authors: Gall Corinna , Nebel Martin , Scholten Thomas , Thielen Sonja M. , Seitz Steffen
Published: November 2023

Mosses are key components of many ecosystems and particularly related to the soil water balance. In principle, the importance of mosses for water-related processes is known; however, their influence is rarely quantified in scientific studies. To fill this research gap, this study concentrates on the influence of mosses of different species on surface runoff, the amount of percolated water, soil erosion, and the temporal dynamics of soil water content. For this purpose, an experimental approach consisting of an ex situ rainfall simulation with infiltration boxes equipped with biocrust wetness probes was applied. On average, mosses significantly reduced surface runoff by 91% and soil erosion by almost 100%, while the amount of percolated water was increased by 85% compared with bare soils. Similarly, the moss treatments tended to have lower water contents in 3 cm soil depth during 30 minutes of rainfall simulations compared to the bare treatments. However, specific effects of moss treatments were superimposed by desiccation cracks as well as soil hydrophobicity, two major factors that clearly override individual species effects. Therefore, it is imperative that further experiments will be conducted to elucidate the apparently underestimated effects of mosses and their specific traits on the soil water balance and sediment transport.
Multi-omics Based Chemical Ecology of Philippine Forest Honey highlights endangered Pterocarpus indicus Willd. tree and important community-driven conservation efforts
Authors: Molino Ralph John Emerson , Weerd Merlijn , Torreno Vicenzo Paolo , Rellin Klidel Fae , Mondragon Miguel , Parungao Louie , Manila-Fajardo Analinda , Santos Daisy May , Junio Hiyas
Published: November 2023

Cooperation among Filipino scientists, conservationists, and forest-based communities paved the way for the chemical ecology investigation of Apis breviligula Maa., Apis cerana Fabr., and Tetragonula biroi (Friese) in priority forest landscapes of the Sierra Madre Mountain Range. The Philippine National Tree and unfortunately endangered Pterocarpus indicus Willd (loc. Narra) proved to be important, especially in Palaui Island where honey from A. cerana is close to being monofloral. Aside from P. indicus and its small molecule marker hypaphorine, caffeine was detected in Palaui honey beautifully reflecting the way of life of native Agtas who manage a small coffee plantation. The abundance of caffeine, however, is higher in stingless honey samples from Tanay, Rizal where Coffea trees have been extensively included in restoration activities over the past few decades. Our results imply the possibility of using honey as an ecological monitoring tool while generating baseline chemical information that reflects the state of Philippine forests. Furthermore, the identification of unique chemical components in forest honey can be further used in programs that assist indigenous communities in safeguarding the ownership and origin of forest honey sources.
Development of simple sequence repeat markers and genetic diversity of Lutraria sieboldii along the northern Beibu Gulf
Authors: Yang Guohao , Han Chunli , Huang Biling , Qin Wenxia , Zhu Peng , Peng Huijing , Xu Youhou , Yang Jialin , Zou Jie , Wang Pengliang
Published: November 2023

Background Lutraria sieboldii is an economically important shellfish in the Beibu Gulf of China. However, genetic diversity has not been systematically reported, and the number of simple sequence repeat (SSR) markers is still limited. These issues seriously hinder germplasm utilization and genetic study.Methods and results SSR markers were identified and developed in the transcriptome, and then the genetic diversity was revealed along the northern Beibu Gulf. We identified a total of 438 SSR loci and designed 329 primers. Of them, 100 SSRs were synthesized and used to reveal genetic diversity. We detected Na of 19.583 with the range from 10 to 36, Ne of 9.139 with the range from 4.075 to 20.629, PIC of 0.861 with the range from 0.723 to 0.949, Ho of 0.516 with the range from 0.000 to 0.964 and He of 0.873 with the range from 0.755 to 0.952 in the population of 117 individuals; the genetic distances between populations ranged from 0.186 to 0.276; Fst ranged from 0.126 to 0.198, and Nm ranged from 1.014 to 1.737; the genetic structure was detected and the population was divided into five groups.Conclusion A total of 438 SSR loci were identified in the transcriptome, and 100 SSR primers of the 329 designed primers were synthesized. The genetic diversity and structure of L. sieboldii along the northern Beibu Gulf were revealed by 36 highly polymorphic SSR markers. These findings will provide useful tools and a solid foundation for the exploration and effective utilization of genetic resources in L. sieboldii.
Using Sentinel-2 satellite images and machine learning algorithms to predict tropical pasture forage biomass, crude protein, and fiber content
Authors: Fernandes Marcia Helena Machado da Rocha , Junior Jalme de Souza Fernandes , Adams Jordan Melissa , Lee Mingyung , Reis Ricardo Andrade , Tedeschi Luis Orlindo
Published: November 2023

Grasslands cover approximately 24% of the Earth’s surface and are the main feed source for cattle and other ruminants. Sustainable and efficient grazing systems require regular monitoring of the quantity and quality of pastures. This study demonstrates the potential of estimating pasture leaf biomass, crude protein (CP) and fiber content of tropical pastures using Sentinel-2 satellite images and machine learning algorithms. Field datasets and satellite images were assessed from an experimental area of Marandu palisade grass pastures, with or without nitrogen fertilization, and managed under continuous stocking during the pasture growing season from 2016 to 2020. Models based on support vector regression (SVR) and random forest (RF) machine-learning algorithms were developed using meteorological data, spectral reflectance, and vegetation indices (VI) as input features. In general, SVR slightly outperformed the RF models. The best predictive models to estimate biomass were those with VI combined with meteorological data. For CP and fiber content, the best predictions were achieved using a combination of spectral bands and meteorological data, resulting in R2 of 0.66 and 0.57, and RMSPE of 0.03 and 0.04 g/g dry matter. Our results have promising potential to improve precision feeding technologies and decision support tools for efficient grazing management.
A Comprehensive Study on MWCNTs and SDS Integration in Anionic Crude Oil for Enhanced EOR Processes
Authors: Bagheri Hamid , Mousavi Seyedborhan , Nami Shamin Hosseini , Heris Saeed Zeinali
Published: November 2023

This research delved into the effects of introducing multi-walled carbon nanotubes (MWCNTs) and sodium dodecyl sulfate (SDS) into crude oil with an anionic base, aiming to enhance its thermophysical attributes in the EOR process. The investigation encompassed a range of properties, including interfacial tension, viscosity, density, and electrical conductivity, measured using an LV rheometer with spindle 18. Various ratios of MWCNTs and SDS were mixed with the crude oil to evaluate their impacts. The study uncovered that the 1:1 ratio of MWCNTs to SDS achieved a noteworthy 10% reduction in interfacial tension while minimally affecting viscosity, showing promise for practical applications. Temperature had diverse effects on viscosity and interfacial tension, displaying fluctuating trends. The highest observed result was a substantial 190% viscosity increase at 40°C with a 2:1 ratio, whereas the lowest was a slight − 0.81% density change at 60°C for the 1:1 ratio. Additionally, interfacial tension consistently decreased over time for all ratios at various temperatures, with the most significant reductions observed at 40°C and 60°C, particularly for the 1:2 and 1:1 ratios. Furthermore, adding MWCNTs and SDS led to a remarkable drop in electrical conductivity, indicating a substantial decrease in salt content within the crude oil. However, it was noted that higher MWCNT concentrations might not be cost-effective, emphasizing the importance of optimizing additive ratios for a balance between performance and economic viability. This study highlights the potential of tailored nanofluid formulations to improve the thermophysical properties of crude oil, potentially enhancing extraction and refining processes.
The use of cell and larval assays to identify target genes for RNA interference mediate control of the Australian sheep blowfly (Lucilia cuprina)
Authors: Yang Yunjia , Zhang Bing , Yong Jiaxi , James Peter , Xu Zhi Ping , Mitter Neena , Mahony Timothy. J , Mody Karishma. T
Published: November 2023

Flystrike is primarily caused by Lucilia cuprina, which is a major health and welfare issue for the sheep in wool industries. Current chemical-based controls can have limited effectiveness due to emerging resistance in the parasite. RNA interference (RNAi), which uses double-stranded RNA (dsRNA) as a trigger molecule, has been successfully investigated for the development of innovative pest control strategies. Although RNAi offers great potential, the efficient identification, selection of target genes and delivery of dsRNA represent challenges to be overcome for the successful application of RNAi for control of L. cuprina. In this study, the application of RNAi was explored using a novel L. cuprina embryonic cell line as well as in vitro larval bioassays. A primary L. cuprina (blowfly) embryo cell line (BFEC) was established and confirmed as being derived from L. cuprina eggs by PCR amplicon sequencing. The BFECs were successfully transfected with plasmids and messenger RNA (mRNA) expressing fluorescent reporter proteins and dsRNA using lipid-based transfection reagents. The transfection of dsRNA into BEFC in this study demonstrated RNAi-mediated knockdown of target gene expression. Three of the dsRNAs identified in this study, resulted in significant reductions in target gene expression in BFEC and loss of biological fitness in a L. cuprina larvae feeding bioassay. This study confirms that the novel BFEC cell line can be used to improve the efficacy of dsRNA-mediated screening to accelerate the identification of potential target genes in the development of RNAi mediated control approaches for L. cuprina. These results contribute to the development of sustainable control strategies for this important agricultural pest.
Research on preprocessing algorithm of indoor map partitioning and global path planning based on FAST
Authors: Yang Jifan , Pan Xunding , Liu Xiaoyang , Wang Lei
Published: November 2023

Path planning is a critical factor in the successful performance of navigation tasks. This paper proposes a novel approach for indoor map partitioning and global path-planning preprocessing. The proposed algorithm aims to enhance the efficiency of path planning tasks by eliminating irrelevant areas. In view of the deformation problem encountered in the original indoor map partitioning method, initially, the contour detection algorithm is employed to identify and eliminate obstacles. Subsequently, the FAST algorithm is utilized to detect key points. These key points are then subjected to filtering and clustering using the K-means algorithm. Based on the 8-neighborhood characteristics, door points and inflection points within the room are selected. A clustering algorithm is employed to retain the door points, which are subsequently connected to form door line segments through averaging and filtering procedures. This process ensures the closure of the sub-room. Finally, the connected domain function is employed to extract the sub-room map, thereby completing the map partitioning process. Based on the sub-room map centroid coordinate point data obtained from the partitioning, two combinations are used as the starting point and the end point, respectively, and the A* algorithm is employed to calculate and store all path information from the starting point to the end point. Based on the sub-room map obtained through partitioning and the stored path information, the path is traversed to eliminate irrelevant areas, thereby achieving the preprocessing of global path planning. The simulation results showed that the A*, Bi-A*, JPS, Dijkstra, PRM, and RRT algorithms increased their rates by 18.2%, 43.6%, 20.5%, 31.9%, 29.1%, and 29.7%, respectively.
Symmetry breaking and spiral similarity of Oseen-like vortex in confined compressible fluid
Authors: Yang Chen
Published: November 2023

Vortex flow has been widely observed in fluid systems in confined regions. In this study, an Oseen-like vortex in a confined compressible fluid was numerically investigated to understand its distinct patterns and associated symmetries. The vortex was studied within multiple two-dimensional polygon confined fluid domains (with different orders) with a rotational solid core in the center. It was demonstrated that the vortex in a compressible fluid is governed by two coexisting mechanisms. Dynamic viscosity provides a circular pattern that is diffusive from the core to the boundary. Shock dynamics provides the mechanism of starry patterns with distinguished arm-like features. The presence of arm-like features alters the symmetries of the original Lamb-Oseen vortex and manifests sensitivity to the initial rotational conditions. In summary, the combined influence of the two coexisting mechanisms generates distinct features from the original Lamb-Oseen vortex. The understanding of the vortex development and features is useful to develop levitation device in microgravity science.
Induction of microbe-mediated responsive proteomes by Methylobacterium oryzae CBMB20 on the salt-tolerant and salt-sensitive rice genotypes towards enhanced salt tolerance
Authors: Walitang Denver I. , Kim Kiyoon , Lee Yi , Choudhury Aritra Roy , Sa Tongmin
Published: November 2023

Background
Salt stress creates combinatorial stress conditions in the plants encompassing ion toxicity, physiological drought, nutritional imbalance, and oxidative stress. Severe salinity critically impacts both sensitive and tolerant rice genotypes. In addition, plants also recruit microbes establishing plant-microbe interactions leading to a complex array of microbe-mediated plant responses resulting to a cumulative overall enhancement of tolerance to salinity. The utilization of proteomics in the study of rice-microbe interactions expands our understanding of microbe-mediated responsive proteomes towards salt stress tolerance.
Results
Under severe salt stress, the proteomes of rice in terms of abundance and identity are mainly influenced by salt stress, rice genotypes, and Methylobacterium oryzae CBMB20 inoculation. Interestingly, the endophytic plant growth-promoting (PGP) M. oryzae CBMB20 mediated changes in the salt-stressed salt-sensitive IR29 resulting to similar proteomes to that of the salt-tolerant FL478. There are common upregulated and downregulated DAPs in both IR29 and FL478 due to salt stress indicating similar mechanisms of salt stress tolerance and similar biological and molecular processes severely affected by salt stress conditions. However, inoculation with M. oryzae CBMB20 resulted to shared significantly increased DAPs between the inoculated IR29 and FL478 indicating common mechanisms of microbe-mediated salt stress tolerance. In addition, there are genotype-specific DAPs with restored functions as a result of the application of M. oryzae CBMB20 in IR29 and FL478 indicating other key proteins essential for microbe-mediated salt stress tolerance.
Conclusions
Under severe salt stress conditions, there are common and genotype-specific proteomic changes in the salt-sensitive and the moderately salt-tolerant rice genotypes. However, the moderately salt-tolerant FL478 upregulated more proteins with higher fold change values indicating more efficient responses to salt stress. The bioinoculation with the versatile PGP M. oryzae CBMB20 onto the two contrasting rice genotypes mediated proteomic changes under salt stress conditions further enhancing stress responses in both rice genotypes.
Role of CDK4 as prognostic biomarker and synergistic effect of its inhibition in dedifferentiated liposarcoma sequential treatment
Authors: Vanni Silvia , Miserocchi Giacomo , Gallo Graziana , Fausti Valentina , Gabellone Sofia , Liverani Chiara , Spadazzi Chiara , Cocchi Claudia , Calabrese Chiara , De Luca Giovanni , Bassi Massimo , Gessaroli Manlio , Tomasetti Nicola , Campobassi Angelo , Pieri Federica , Ercolani Giorgio , Cavaliere Davide , Gurrieri Lorena , Riva Nada , Recine Federica , Ibrahim Toni , Mercatali Laura , Jones Robin , De Vita Alessandro
Published: November 2023

Background
Soft tissue sarcomas represent a heterogeneous group of rare mesenchymal tumors comprising 1% of all solid malignancies. Among them liposarcoma is one of the most common histotypes, with atypical lipomatous tumor/well differentiated liposarcoma and dedifferentiated liposarcoma (ALT/WDLPS and DDLPS) as the major sub entities. The unavailability of predictive, prognostic and druggable biomarkers make the management of these lesions challenging. In recent years, CDK4 and its inhibitors have emerged as potential weapons for these lesions especially for ALT/WDLPS and DDLPS but the results are not conclusive and need to be elucidated.
Methods
This study involved 21 ALT/WDLPS and DDLPS patients. Histological analyses of MDM2 and CDK4 were carried out. Moreover, a DDLPS patient-derived cancer model was established in vitro and in vivo assessing the efficacy of palbociclib in combination and sequential treatment. Finally, in silico analyses on CDK4 expression were carried out.
Results
The results showed a higher expression of CDK4 and MDM2 in DDLPS compared to ALT/WDLPS. Moreover, no correlation between MDM2 expression and CDK4 was observed. In addition, CDK4 expression seemed to correlate with specific anatomic regions. Next, in vitro analysis of CDK4 inhibitor palbociclib showed an antagonistic effect when combined to other chemotherapeutics, while it exhibited a significant synergy when administered in sequential schedule in both 2D and 3D culture models with ifosfamide, ifosfamide plus epirubicin, trabectedin, dacarbazine, eribulin and lenvatinib. The data were further corroborated by scratch wound healing assay and live-dead analysis. Next, in vivo analysis on DDLPS xenotransplanted embryos assessing the efficacy and safety profile of the in vitro tested schedules confirmed the observed data. Finally, in silico analysis supported the role of CDK4 in sarcoma management, especially DDLPS.
Conclusion
This proof-of-concept study sheds light on the natural history of ALT/WDLPS and DDLPS and provides the rationale for the clinical applicability of sequential treatment with palbociclib in the management of DDLPS.
Google Trends Forecasting: Model re-specification of time-series for enhancing forecasts of youth unemployment
Authors: Wijnhoven Fons , De Bruijn Nathan , Effing Robin
Published: November 2023

In the last decades, the forecasting field has been using the surge in big data and advanced computational capabilities. Despite these developments, forecasters continue using traditional forecasting procedures that assume static relationships between phenomena. To address the reality of dynamic relations among phenomena, this study discusses time-variant re-specification methods as part of time-series based forecasts and compares the outcomes with the traditional procedures. This method-comparison is applied to a real-world exercise, the forecasting of Dutch youth unemployment with big data based on Google Trends. For youth unemployment forecasts, our results show 44% more forecasting accuracy by time-varying forecasting models than the traditional static forecasting models. Additionally, this study makes labour market forecasting an accessible endeavour to all organizations by sharing the algorithm for forecasting youth unemployment rates with publicly available data such as Google Trends. Moreover, our study stresses a reconsideration of forecasting methodologies towards model re-specification instead of model recalibration.
Intelligent Integration of Assessment Tools for Specialized Prognosis in Spinal Cord Injuries: A scoping review
Authors: Chrysanthakopoulou Dionysia , Koutsojannis Constantinos , Matzaroglou Charalampos , Trachani Eftychia
Published: November 2023

Spinal cord injury is a life-threatening condition resulting from spinal cord trauma, leading to paralysis, loss of sensation, bowel and bladder control. Accurate assessment tools are crucial for diagnosing and treating spinal cord injuries, and various scales have been developed for this purpose. Additionally, electrophysiological measures, including somatosensory evoked potentials, motor evoked potentials, and nerve conduction studies, can aid in patient stratification. Recent developments in spinal cord injury assessment have shown promise, particularly with the use of advanced imaging techniques and artificial intelligence. Neuroimaging and molecular biomarkers combined with electrophysiological measures, promise to predict outcomes and guide treatment decisions. Machine learning and Artificial intelligence have revolutionized the healthcare industry, including the field of spinal cord injuries, as they can facilitate personalized medicine by accurately predicting. Challenges remain in validating machine learning models and ensuring they are safe and effective for clinical use. Quality data and expertise are crucial for accurately interpreting and applying machine learning results in spinal cord injury management. Moreover, due to artificial intelligence entering healthcare to assist in processing data, electrophysiology can eventually meet the high-quality information it can provide, as it is easier to analyze data recordings from somatosensory evoked potentials and other electrophysiologic measures. Summing up, the integration of advanced imaging techniques, biomarkers, and machine learning leading to maximizing the use and importance of electrophysiology as far as the information it can reveal, has the potential to revolutionize the diagnosis, prognosis, and treatment of spinal cord injuries, leading to improved patient outcomes and personalized care.
The Impact of Subclinical Hypothyroidism on Lipid Profile in Jeddah
Authors: Alzahrani Mahmoud Abdullah , Baqar Fatimah Saeed , Alzahrani Basil A. , Badri Ziyad A. , Alshamrani Rayan M. , Aljuhani Jamal A.
Published: November 2023

Background
Patients with subclinical hypothyroidism have a high serum concentration of thyroid-stimulating hormone, whereas their serum free thyroxine concentrations are normal. Lipid metabolism is regulated in large part by thyroid hormones. It could be connected to a changed lipid profile. The purpose of the current study was to evaluate the relationship between subclinical hypothyroidism and alterations in the lipid profile.
Methods
Data of 99 patients with subclinical hypothyroidism and 109 euthyroid cases were collected from king Abdulaziz medical city, Jeddah, Saudi Arabia from 2016–2022. Patients older than 18 years, and the groups were matched in terms of gender, age, and body mass index (BMI). SCH was defined as a TSH value of 4.5 to 10 mU/L, and normal T4 as 5 to 18 µg/dL. Control cases had a normal TSH ranging from 0.45 to 4.5 mU/L. The total serum cholesterol (TCHOL), high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglyceride (TG) levels in both groups were examined and the results were recorded.
Result
In comparison to the control group, SCH patients had greater median HbA1C (p = 0.001) and lower median vitamin D levels (p = 0.004) prior to therapy. Before therapy, SCH patients also showed considerably lower HDL levels and significantly higher LDL and triglyceride levels (p < 0.001).
Conclusion
there is a substantial correlation between subclinical hypothyroidism and reduced HDL and vitamin D levels. It was linked to increased triglyceride, LDL, and HbA1c levels. Only vitamin D and low-density lipoproteins were pathologically high. Treatment with levothyroxine raised total and LDL cholesterol levels. Future research ought to look into how affordable treating subclinical hypothyroidism is.
Digitize! – Computational Social Science in der digitalen und sozialen Transformation
Authors: Kritzinger Sylvia , Pfaff Katharina , Barta Julia , Bernhard Jana , Boomgaarden Hajo , Eder Anja , Forgó Nikolaus , Paspalj Filip , Plant Claudia , Prainsack Barbara , Prandner Dimitri , Rittel Simon , Teuffenbach Martin , Tschiatschek Sebastian
Published: November 2023

Die Digitalisierung bringt neben vielen Vorteilen für die sozialwissenschaftliche Forschung und die Lehre auch neue Herausforderungen mit sich. Die Weiterentwicklung digitaler Datenerhebungs- und Analyseverfahren zur Analyse und Gestaltung gesellschaftlicher und politischer Transformationsprozesse muss im Fokus der Zukunftsausrichtung sozialwissenschaftlicher Hochschullehre und Forschung stehen. Neue Datenformate und Praktiken erfordern neue forschungsethische und datenschutzrechtliche Praktiken und Standards. Im Zentrum von Computational Social Science steht die juristisch und ethisch fundierte, reflektierte Nutzbarmachung von digitalen Forschungsdaten und Analyseverfahren und ihre Vermittlung.
Dynamical localization and slow thermalization in a class of disorder-free periodically driven one-dimensional interacting systems
Authors: Aditya Sreemayee , Sen Diptiman
Published: November 2023

We study if the interplay between dynamical localization and interactions in periodically driven quantum systems can give rise to anomalous thermalization behavior. Specifically, we consider one-dimensional models with interacting spinless fermions with nearest-neighbor hopping and density-density interactions, and a periodically driven on-site potential with spatial periodicity m=2 and m=4. At a dynamical localization point, these models evade thermalization either due to the presence of an extensive number of conserved quantities (for weak interactions) or due to the kinetic constraints caused by drive-induced resonances (for strong interactions). Our models therefore illustrate interesting mechanisms for generating constrained dynamics in Floquet systems which are difficult to realize in an undriven system.
Los trascendentales en cuanto clave cognoscitiva del Creador por medio de la criatura, y como condición de posibilidad de la estructura del universo
Authors: Velarde Lizama Catalina
Published: November 2023

En este artículo se quiere mostrar cómo el bien la verdad y la belleza, al ser propiedades que se identifican con el ser, es decir, trascendentales, develan algunas características del ser perfecto en los entes imperfectos. Esto es posible desde el pensamiento de Tomás de Aquino, porque dios, que es aquel que crea, al hacerlo transmite algo de su propio ser a su obra; así como el artista se refleja en algún respecto en su creación. En el caso de dios, este reflejo se llama vestigio, y tiene carácter analógico. Sin embargo, permite que una criatura racional encarnada pueda descubrirlo por medio de la contemplación del universo, lo que transforma a la creación en un fenómeno ierofánico. En este trabajo mostraremos cómo cada trascendental revela un aspecto de la divinidad. La verdad la hace inteligible, la bondad deseable y la belleza digna de ser amada.
Metafísica, antropología y virtud moral en san Gregorio de Nisa
Authors: Buganza Jacob
Published: November 2023

Este trabajo estudia el concepto de virtud moral a partir de dos obras de san Gregorio de Nisa, a saber, De professione Christiana yDe perfectione, pertenecientes a la etapa inmediatamente anterior a la madurez de su autor, signada sobre todo por el De vita Moysis,que mucha atención ha merecido. Sin embargo, algunas de las tesis características de esta última obra se encuentran ya trazadas en las primeras dos, especialmente la propuesta de que la virtud es una tarea inabarcable e infinita, como infinita es la naturaleza de Dios. Por ello, el artículo estudia, primero, en qué consiste la infinitud divina de acuerdo con el Niseno, siguiendo para ello, específicamente, el Contra Eunomium; luego, hace lo propio en relación a la antropología filosófica que, desde la visión de este trabajo, resulta ser el puente entre el ámbito metafísico y el moral, pues infinita es también la labor moral del hombre, y, finalmente, expone en qué consiste la virtud moral en las dos obras mencionadas.
El abismo de todos los abismos: ¿«Dios no ama a todos los hombres»?
Authors: Silva Camilo
Published: November 2023

La presente contribución tiene por objeto develar y dar respuesta a ciertas dificultades propias de la definición de la justicia basada en el concepto de amor profesada por el joven Leibniz. En un esfuerzo por capitalizar una definición de la justicia sobre la cual sea posible materializar su proyecto de una jurisprudencia universal, Leibniz encuentra en el concepto de amor el elemen­to central de la justicia. Sin embargo, frente a esta indagación de carácter puramente especulativo, aparece la experiencia, que revela la existencia de injusticias en el mundo. Admitiendo la existencia del mal y de injusticias, Dios todopoderoso no parece –como ha de ser no obstante el caso– amar a todos los hombres. Si Leibniz no enuncia explícitamente esta conse­cuencia que se deduce del contraste entre su definición de la justicia y la experiencia, ella es, empero, el acápite con que él pretende resolver el problema en su primera teodicea: la Con­fessio Philosophi. Antes que la predestinación, es la herética consecuencia según la cual Dios no ama a todos los hombres lo que motiva la reflexión de Leibniz en la Confessio, y la que guía su solución a dicho problema.
Augustine's concept of Person in Martin Buber’s personalism
Authors: Torres Brizuela Juan Facundo
Published: November 2023

The question about man appears again in contemporary philosophy no longer as an eidetic, but as an existential question (if it ever ceased to be so). Martin Buber, Austrian-Jewish thinker (1878-1965), seeks with his thought to recover the value of man, adding to the existentialist influences of Kierkegaard and Nietzsche, and to the phenomenological influence of Husserl, the dialogic principle; that is, the necessity of the other as a Thou for the becoming of the I as a person. This last concept, person, has its origin in the philosophical discourse in the Trinitarian and Christological Theology of the Fathers of the Church, among them, Augustine of Hippo. In this article we want to make explicit the presence of this Augustinian conception of person in the personalism of Martin Buber. To do so, we will identify the most important characteristics of the person for the bishop of Hippo, which are explained in detail in his work De Trinitate, and then we will link these characteristics with those that are central to Buber's thought. Our hypothesis is that we can find in Buber's anthropology traces of Augustine's thought, influenced especially through existentialism and phenomenology.
Possible mechanisms of phlebitis-like abnormal reaction (PLAR) after cyanoacrylate obliteration of varicose veins
Authors: Sannikov A. B. , Shaydakov E. V.
Published: November 2023

Based on their own research and a review of the literature, the authors analyze the possible cellular mechanisms of the development of an inflammatory reaction after the obliteration of varicose veins with cyanoarylate adhesive compounds (CAO), which received the name phlebitis- Like abnormal Reaction (PLAR) in foreign sources. Despite the existing opinion about the “abnormal” nature of the inflammatory reaction, it is noted that the main stages of its development are fully consistent with the currently known molecular and cellular mechanisms of the response of biological tissues to contact with a foreign antigenic substance and are of a natural nature. The cause of the development of acute alterative inflammation in the vein wall is the direct contact of the endothelium with an aggressive environment, which is cyanoacrylate. A specific feature of the development of chronic inflammation in the vein wall is its productive interdaily character, which is replaced by proliferative processes. The main role in the development of successive stages of PLAR development is played by monocytic, mast and giant cells of foreign bodies, as well as the mechanisms underlying the regulation of the functional activity of these cells. During the period of cyanoacrylate biodegradation, its cellular environment corresponds to all morphological features of a phagocytoma, whose activity decreases with the biodegradation of cyanoacrylate with simultaneous connective tissue proliferation. The development of possible chronic granulomatous inflammation is based on a local autoimmune process associated with the formation of giant multinucleated epithelioid cells (Langerhans cells). In conclusion, it is emphasized that today, when using various cyanoacrylate compounds for the purpose of adhesive obliteration of veins, taking into account the accumulated clinical data and morphological studies, the final answers to the existing reasonable objections about the complete safety of the use of cyanoacrylates in clinical practice should be given by fundamental immunohistochemical and genetic studies.
Diagnostic significance of endotoxin and antitoxic opsonin – fibronectin in the blood flow in purulent-necrotic inflammatory of the lower limb in patients with diabetes mellitus
Authors: Pikuza A. V. , Zakirov A. M. , Akhunzyanov A. A. , Pikuza A. A.
Published: November 2023

Introduction. In the cascade of pathogenetic mechanisms of diabetes mellitus, one of the central positions is occupied by systemic vascular lesions, including the lower extremities with the formation of diabetic foot syndrome. Aim. To investigate and evaluate the diagnostic significance of endotoxin concentration and plasma fibronectin parameters in indicating the severity of purulent-necrotic inflammation of the feet in patients with diabetes mellitus. Materials and methods. The study included 112 patients with purulent-necrotic inflammation of the feet aged 61.4 ± 12.5 years. By types of surgical intervention, patients were divided into groups: the main group (21 patients with transmetadarsal ammutation of the foot and 27 with amputation at the level of the lower leg), the comparison group – 64 patients with necrectomy and plastic closure of wounds on the foot. The concentration of endotoxin in the bloodstream was determined by the micro-LAL test (EU/ml), the content of plasma fibronectin was assessed by enzyme immunoassay (µg/ml). Results. With the progressive development of purulent inflammation of the feet in patients of the main group, the concentration of endotoxin reached 9.32 (0.91) EU/ml, in the comparison group – 5.73 (0.36) EU/ml, in which purulent-necrotic the process was limited. In the main group of examined patients, hypofibronectinemia also had a more significant character. At the same time, the lowest fibronectin in patients was observed with an extensive purulent-necrotic process, in whom an amputation was performed at the level of the lower leg – 124.7 (6.2) µg/ml, the concentration of endotoxin in them reached the maximum figures – 10.51 (0.5) EU/ml. Discussion.The main factor determining the depth of endotoxin aggression and destructive lesions of the extremities can be the enhanced utilization of fibronectin. Conclusion. The progression of endotoxin aggression is a predictor of an increase in the severity of destructive tissue damage in patients with diabetes mellitus.
Percutaneous laser coagulation of dilated intradermal veins: from theory to practice
Authors: Bogachev V. Yu. , Manjikian H. P. , Alukhanyan O. A.
Published: November 2023

Review authors consider the current possibilities of percutaneous laser coagulation for telangiectasias and reticular veins, which are the most common cosmetic defects of vascular genesis, occurring in more than 80% of women of different age groups. This vascular pathology constituting an aesthetic defect and causing local physical discomfort is one of the most common indications for phlebosclerosing therapy and percutaneous laser coagulation. The authors present the most effective and safe guidelines for percutaneous laser coagulation based on analyses of a large volume of specialized literature. Due to the use of state-of-the-art Nd:YAG lasers, percutaneous laser coagulation is increasingly used in patients with various types of intradermal vein lesions and, owing to high efficiency and safety, has advantages over compression sclerotherapy by several criteria. Nd:YAG lasers can be divided into long- and short-pulse ones according to their technical characteristics. Long-pulse lasers provide coagulation of the target vessel due to a single pulse with a high energy density (fluence), while short-pulse lasers, on the contrary, generate a series of pulses to the target vein with a running time of fractions of a millisecond, which ensures the conversion of hemoglobin into methemoglobin with a ten-fold increased ability to absorb laser energy and convert it to heat. As the duration of the pulses generated by the device is a priori shorter than the thermal relaxation time, the risk of burns to the skin and paravasal structures almost completely disappears. The authors provide clinical examples of the application of Aerolase Neo device that utilizes MicroPulse technology to confirm the effectiveness and safety of shortpulse Nd:YAG lasers.
A case report of surgical complications in a patient with ulcerative colitis
Authors: Turkin P. Yu. , Slesareva A. A. , Talanova V. A. , Burchakov I. A. , Stetsiuk O. A. , Dolgiev A. Kh. , Golosnitskiy P. Yu. , Podoltseva E. P. , Dolgikh I. B.
Published: November 2023

Rapidly rising prevalence of ulcerative colitis in developed countries among young population compels the medical community to pay attention not only to the problems of early diagnosis and therapy of this disease, but also to preventing the development of complications, that may lead to disability. This article reviews a clinical case of the development of surgical complications in a patient with a long-term active course of ulcerative colitis, who has been also suffering from autoimmune hepatitis and primary sclerosing cholangitis for 20 years. The prolonged active course of the disease and total damage to the colon, association with primary sclerosing cholangitis, as well as the patient’s low adherence to therapy were risk factors for the development of adenocarcinoma of the ascending colon, which required radical surgical treatment. The formation of adhesive disease and multiple abdominal abscesses can be noted as long-term complications, which led to the repeated use of invasive methods of treatment. Over the next few months, the patient experienced 2 more episodes of local purulent complications that required surgical treatment due to the ineffectiveness of antibiotic therapy. All episodes of purulent complications were accompanied by progressive leukopenia due to prolonged use of immunosuppressive drugs. In our opinion, in patients with ulcerative colitis who take cytostatic agents for a long time, special attention should be paid to monitoring and correcting leukopenia, as well as preventing the development of purulent complications.