bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA methylation of oestrogen-regulated enhancers defines endocrine sensitivity in breast cancer
Authors: Stone Andrew , Zotenko Elena , Locke Warwick J. , Korbie Darren , Millar Ewan K. A. , Pidsley Ruth , Stirzaker Clare , Graham Peter , Trau Matt , Musgrove Elizabeth A. , Nicholson Robert I. , Gee Julia M. W. , Clark Susan J.
Published: July 2015

Expression of oestrogen receptor (ESR1) determines whether a breast cancer patient receives endocrine therapy, but does not guarantee patient response. The molecular factors that define endocrine response in ESR1-positive breast cancer patients remain poorly understood. Here we characterize the DNA methylome of endocrine sensitivity and demonstrate the potential impact of differential DNA methylation on endocrine response in breast cancer. We show that DNA hypermethylation occurs predominantly at oestrogen-responsive enhancers and is associated with reduced ESR1 binding and decreased gene expression of key regulators of ESR1 activity, thus providing a novel mechanism by which endocrine response is abated in ESR1-positive breast cancers. Conversely, we delineate that ESR1-responsive enhancer hypomethylation is critical in transition from normal mammary epithelial cells to endocrine-responsive ESR1-positive cancer. Cumulatively, these novel insights highlight the potential of ESR1-responsive enhancer methylation to both predict ESR1-positive disease and stratify ESR1-positive breast cancer patients as responders to endocrine therapy.
Invasiveness and metastasis of retinoblastoma in an orthotopic zebrafish tumor model
Authors: Chen Xiaoyun , Wang Jian , Cao Ziquan , Hosaka Kayoko , Jensen Lasse , Yang Huasheng , Sun Yuping , Zhuang Rujie , Liu Yizhi , Cao Yihai
Published: July 2015

Retinoblastoma is a highly invasive malignant tumor that often invades the brain and metastasizes to distal organs through the blood stream. Invasiveness and metastasis of retinoblastoma can occur at the early stage of tumor development. However, an optimal preclinical model to study retinoblastoma invasiveness and metastasis in relation to drug treatment has not been developed. Here, we developed an orthotopic zebrafish model in which retinoblastoma invasion and metastasis can be monitored at a single cell level. We took the advantages of immune privilege and transparent nature of developing zebrafish embryos. Intravitreal implantation of color-coded retinoblastoma cells allowed us to kinetically monitor tumor cell invasion and metastasis. Further, interactions between retinoblastoma cells and surrounding microvasculatures were studied using a transgenic zebrafish that exhibited green fluorescent signals in blood vessels. We discovered that tumor cells invaded neighboring tissues and blood stream when primary tumors were at the microscopic sizes. These findings demonstrate that retinoblastoma metastasis occurs at the early stage and antiangiogenic drugs such as Vegf morpholino and sunitinib could potentially interfere with tumor invasiveness and metastasis. Thus, this orthotopic retinoblastoma model offers a new and unique opportunity to study the early events of tumor invasion, metastasis and drug responses.
Magnetic moment formation due to arsenic vacancies in LaFeAsO-derived superconductors
Authors: Kikoin Konstantin , Drechsler Stefan-Ludwig , Koepernik Klaus , Málek Jiři , van den Brink Jeroen
Published: July 2015

Arsenic vacancies in LaFeAsO-derived superconductors are nominally non-magnetic defects. However, we find from a microscopic theory in terms of an appropriately modified Anderson-Wolff model that in their vicinity local magnetic moments form. They can arise because removing an arsenic atom breaks four strong, covalent bonds with the neighboring iron atoms. The moments emerging around an arsenic vacancy orient ferromagnetically and cause a substantial enhancement of the paramagnetic susceptibility in both the normal and superconducting state. The qualitative model description is supported by first principles band structure calculations of the As-vacancy related defect spectrum within a larger supercell.
Band Alignment and Controllable Electron Migration between Rutile and Anatase TiO2
Authors: Mi Yang , Weng Yuxiang
Published: July 2015

TiO2 is the most promising semiconductor for photocatalytic splitting of water for hydrogen and degradation of pollutants. The highly photocatalytic active form is its mixed phase of two polymorphs anatase and rutile rather than their pristine compositions. Such a synergetic effect is understood by the staggered band alignment favorable to spatial charge separation. However, electron migration in either direction between the two phases has been reported, the reason of which is still unknown. We determined the band alignment by a novel method, i.e., transient infrared absorption-excitation energy scanning spectra, showing their conduction bands being aligned, thus the electron migration direction is controlled by dynamical factors, such as varying the particle size of anatase, putting electron or hole scavengers on either the surface of anatase or rutile phases, or both. A quantitative criterion capable of predicting the migration direction under various conditions including particle size and surface chemical reactions is proposed, the predictions have been verified experimentally in several typical cases. This would give rise to a great potential in designing more effective titania photocatalysts.
Hierarchical Nanotube-Constructed Porous TiO2-B Spheres for High Performance Lithium Ion Batteries
Authors: Cai Yi , Wang Hong-En , -Zhuan Huang Shao , Jin Jun , Wang Chao , Yu Yong , Li Yu , Su Bao-Lian
Published: July 2015

Hierarchically structured porous TiO2-B spheres have been synthesized via a hydrothermal process using amorphous titania/oleylamine composites as a self-sacrificing template. The TiO2-B spheres are constructed by interconnected nanotubes and possess a high specific surface area of 295 m2 g-1. When evaluated as an anode material in lithium-half cells, the as-obtained TiO2-B material exhibits high and reversible lithium storage capacity of 270 mA h g-1 at 1 C (340 mA g-1), excellent rate capability of 221 mA h g-1 at 10 C and long cycle life with over 70% capacity retention after 1000 cycles at 10 C. The superior electrochemical performance of TiO2-B material strongly correlates to the synergetic superiorities with a combination of TiO2-B polymorph, hierarchically porous structure, interconnected nanotubes and spherical morphology. Post-mortem structural analyses reveal some discrete cubic LiTiO2 nanodots formed on the outer surfaces of TiO2-B nanotubes, which might account for the slight capacity loss upon prolonged electrochemical cycling.
Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases
Authors: Basarab Gregory S. , Kern Gunther H. , McNulty John , Mueller John P. , Lawrence Kenneth , Vishwanathan Karthick , Alm Richard A. , Barvian Kevin , Doig Peter , Galullo Vincent , Gardner Humphrey , Gowravaram Madhusudhan , Huband Michael , Kimzey Amy , Morningstar Marshall , Kutschke Amy , Lahiri Sushmita D. , Perros Manos , Singh Renu , Schuck Virna J. A. , Tommasi Ruben , Walkup Grant , Newman Joseph V.
Published: July 2015

With the diminishing effectiveness of current antibacterial therapies, it is critically important to discover agents that operate by a mechanism that circumvents existing resistance. ETX0914, the first of a new class of antibacterial agent targeted for the treatment of gonorrhea, operates by a novel mode-of-inhibition against bacterial type II topoisomerases. Incorporating an oxazolidinone on the scaffold mitigated toxicological issues often seen with topoisomerase inhibitors. Organisms resistant to other topoisomerase inhibitors were not cross-resistant with ETX0914 nor were spontaneous resistant mutants to ETX0914 cross-resistant with other topoisomerase inhibitor classes, including the widely used fluoroquinolone class. Preclinical evaluation of ETX0914 pharmacokinetics and pharmacodynamics showed distribution into vascular tissues and efficacy in a murine Staphylococcus aureus infection model that served as a surrogate for predicting efficacious exposures for the treatment of Neisseria gonorrhoeae infections. A wide safety margin to the efficacious exposure in toxicological evaluations supported progression to Phase 1. Dosing ETX0914 in human volunteers showed sufficient exposure and minimal adverse effects to expect a highly efficacious anti-gonorrhea therapy.
Digestion of Nucleic Acids Starts in the Stomach
Authors: Liu Yu , Zhang Yanfang , Dong Ping , An Ran , Xue Changhu , Ge Yinlin , Wei Liangzhou , Liang Xingguo
Published: July 2015

The ingestion of nucleic acids (NAs) as a nutritional supplement or in genetically modified food has attracted the attention of researchers in recent years. Discussions over the fate of NAs led us to study their digestion in the stomach. Interestingly, we found that NAs are digested efficiently by human gastric juice. By performing digests with commercial, recombinant and mutant pepsin, a protein-specific enzyme, we learned that the digestion of NAs could be attributed to pepsin rather than to the acidity of the stomach. Further study showed that pepsin cleaved NAs in a moderately site-specific manner to yield 3′-phosphorylated fragments and the active site to digest NAs is probably the same as that used to digest protein. Our results rectify the misunderstandings that the digestion of NAs in the gastric tract begins in the intestine and that pepsin can only digest protein, shedding new light on NA metabolism and pepsin enzymology.
Studying biological membranes with extended range high-speed atomic force microscopy
Authors: Nievergelt Adrian P. , Erickson Blake W. , Hosseini Nahid , Adams Jonathan D. , Fantner Georg E.
Published: July 2015

High—speed atomic force microscopy has proven to be a valuable tool for the study of biomolecular systems at the nanoscale. Expanding its application to larger biological specimens such as membranes or cells has, however, proven difficult, often requiring fundamental changes in the AFM instrument. Here we show a way to utilize conventional AFM instrumentation with minor alterations to perform high-speed AFM imaging with a large scan range. Using a two—actuator design with adapted control systems, a 130 × 130 × 5 μm scanner with nearly 100 kHz open—loop small-signal Z—bandwidth is implemented. This allows for high-speed imaging of biologically relevant samples as well as high-speed measurements of nanomechanical surface properties. We demonstrate the system performance by real-time imaging of the effect of charged polymer nanoparticles on the integrity of lipid membranes at high imaging speeds and peak force tapping measurements at 32 kHz peak force rate.
iCut: an Integrative Cut Algorithm Enables Accurate Segmentation of Touching Cells
Authors: He Yong , Gong Hui , Xiong Benyi , Xu Xiaofeng , Li Anan , Jiang Tao , Sun Qingtao , Wang Simin , Luo Qingming , Chen Shangbin
Published: July 2015

Individual cells play essential roles in the biological processes of the brain. The number of neurons changes during both normal development and disease progression. High-resolution imaging has made it possible to directly count cells. However, the automatic and precise segmentation of touching cells continues to be a major challenge for massive and highly complex datasets. Thus, an integrative cut (iCut) algorithm, which combines information regarding spatial location and intervening and concave contours with the established normalized cut, has been developed. iCut involves two key steps: (1) a weighting matrix is first constructed with the abovementioned information regarding the touching cells and (2) a normalized cut algorithm that uses the weighting matrix is implemented to separate the touching cells into isolated cells. This novel algorithm was evaluated using two types of data: the open SIMCEP benchmark dataset and our micro-optical imaging dataset from a Nissl-stained mouse brain. It has achieved a promising recall/precision of 91.2 ± 2.1%/94.1 ± 1.8% and 86.8 ± 4.1%/87.5 ± 5.7%, respectively, for the two datasets. As quantified using the harmonic mean of recall and precision, the accuracy of iCut is higher than that of some state-of-the-art algorithms. The better performance of this fully automated algorithm can benefit studies of brain cytoarchitecture.
Crystalline Ni3C as both carbon source and catalyst for graphene nucleation: a QM/MD study
Authors: Jiao Menggai , Li Kai , Guan Wei , Wang Ying , Wu Zhijian , Page Alister , Morokuma Keiji
Published: July 2015

Graphene nucleation from crystalline Ni3C has been investigated using quantum chemical molecular dynamics (QM/MD) simulations based on the self-consistent-charge density-functional tight-binding (SCC-DFTB) method. It was observed that the lattice of Ni3C was quickly relaxed upon thermal annealing at high temperature, resulting in an amorphous Ni3C catalyst structure. With the aid of the mobile nickel atoms, inner layer carbon atoms precipitated rapidly out of the surface and then formed polyyne chains and Y-junctions. The frequent sinusoidal-like vibration of the branched carbon configurations led to the formation of nascent graphene precursors. In light of the rapid decomposition of the crystalline Ni3C, it is proposed that the crystalline Ni3C is unlikely to be a reaction intermediate in the CVD-growth of graphene at high temperatures. However, results present here indicate that Ni3C films can be employed as precursors in the synthesis of graphene with exciting possibility.
Electron—phonon Coupling and the Superconducting Phase Diagram of the LaAlO3—SrTiO3 Interface
Authors: Boschker Hans , Richter Christoph , Fillis-Tsirakis Evangelos , Schneider Christof W. , Mannhart Jochen
Published: July 2015

The superconductor at the LaAlO3—SrTiO3 interface provides a model system for the study of two-dimensional superconductivity in the dilute carrier density limit. Here we experimentally address the pairing mechanism in this superconductor. We extract the electron—phonon spectral function from tunneling spectra and conclude, without ruling out contributions of further pairing channels, that electron—phonon mediated pairing is strong enough to account for the superconducting critical temperatures. Furthermore, we discuss the electron—phonon coupling in relation to the superconducting phase diagram. The electron—phonon spectral function is independent of the carrier density, except for a small part of the phase diagram in the underdoped region. The tunneling measurements reveal that the increase of the chemical potential with increasing carrier density levels off and is zero in the overdoped region of the phase diagram. This indicates that the additionally induced carriers do not populate the band that hosts the superconducting state and that the superconducting order parameter therefore is weakened by the presence of charge carriers in another band.
Serum proteomic profiling of major depressive disorder
Authors: Bot M , Chan M K , Jansen R , Lamers F , Vogelzangs N , Steiner J , Leweke F M , Rothermundt M , Cooper J , Bahn S , Penninx B W J H
Published: July 2015

Much has still to be learned about the molecular mechanisms of depression. This study aims to gain insight into contributing mechanisms by identifying serum proteins related to major depressive disorder (MDD) in a large psychiatric cohort study. Our sample consisted of 1589 participants of the Netherlands Study of Depression and Anxiety, comprising 687 individuals with current MDD (cMDD), 482 individuals with remitted MDD (rMDD) and 420 controls. We studied the relationship between MDD status and the levels of 171 serum proteins detected on a multi-analyte profiling platform using adjusted linear regression models. Pooled analyses of two independent validation cohorts (totaling 78 MDD cases and 156 controls) was carried out to validate our top markers. Twenty-eight analytes differed significantly between cMDD cases and controls (P<0.05), whereas 10 partly overlapping markers differed significantly between rMDD cases and controls. Antidepressant medication use and comorbid anxiety status did not substantially impact on these findings. Sixteen of the cMDD-related markers had been assayed in the pooled validation cohorts, of which seven were associated with MDD. The analytes prominently associated with cMDD related to diverse cell communication and signal transduction processes (pancreatic polypeptide, macrophage migration inhibitory factor, ENRAGE, interleukin-1 receptor antagonist and tenascin-C), immune response (growth-regulated alpha protein) and protein metabolism (von Willebrand factor). Several proteins were implicated in depression. Changes were more prominent in cMDD, suggesting that molecular alterations in serum are associated with acute depression symptomatology. These findings may help to establish serum-based biomarkers of depression and could improve our understanding of its pathophysiology.
Development of a blood-based molecular biomarker test for identification of schizophrenia before disease onset
Authors: Chan M K , Krebs M-O , Cox D , Guest P C , Yolken R H , Rahmoune H , Rothermundt M , Steiner J , Leweke F M , van Beveren N J M , Niebuhr D W , Weber N S , Cowan D N , Suarez-Pinilla P , Crespo-Facorro B , Mam-Lam-Fook C , Bourgin J , Wenstrup R J , Kaldate R R , Cooper J D , Bahn S
Published: July 2015

Recent research efforts have progressively shifted towards preventative psychiatry and prognostic identification of individuals before disease onset. We describe the development of a serum biomarker test for the identification of individuals at risk of developing schizophrenia based on multiplex immunoassay profiling analysis of 957 serum samples. First, we conducted a meta-analysis of five independent cohorts of 127 first-onset drug-naive schizophrenia patients and 204 controls. Using least absolute shrinkage and selection operator regression, we identified an optimal panel of 26 biomarkers that best discriminated patients and controls. Next, we successfully validated this biomarker panel using two independent validation cohorts of 93 patients and 88 controls, which yielded an area under the curve (AUC) of 0.97 (0.95–1.00) for schizophrenia detection. Finally, we tested its predictive performance for identifying patients before onset of psychosis using two cohorts of 445 pre-onset or at-risk individuals. The predictive performance achieved by the panel was excellent for identifying USA military personnel (AUC: 0.90 (0.86–0.95)) and help-seeking prodromal individuals (AUC: 0.82 (0.71–0.93)) who developed schizophrenia up to 2 years after baseline sampling. The performance increased further using the latter cohort following the incorporation of CAARMS (Comprehensive Assessment of At-Risk Mental State) positive subscale symptom scores into the model (AUC: 0.90 (0.82–0.98)). The current findings may represent the first successful step towards a test that could address the clinical need for early intervention in psychiatry. Further developments of a combined molecular/symptom-based test will aid clinicians in the identification of vulnerable patients early in the disease process, allowing more effective therapeutic intervention before overt disease onset.
Alterations in circadian entrainment precede the onset of depression-like behavior that does not respond to fluoxetine
Authors: Spulber S , Conti M , DuPont C , Raciti M , Bose R , Onishchenko N , Ceccatelli S
Published: July 2015

Growing evidence links adverse prenatal conditions to mood disorders. We investigated the long-term behavioral alterations induced by prenatal exposure to excess glucocorticoids (dexamethasone—DEX). At 12 months, but not earlier, DEX-exposed mice displayed depression-like behavior and impaired hippocampal neurogenesis, not reversible by the antidepressant fluoxetine (FLX). Concomitantly, we observed arrhythmic glucocorticoid secretion and absent circadian oscillations in hippocampal clock gene expression. Analysis of spontaneous activity showed progressive alterations in circadian entrainment preceding depression. Circadian oscillations in clock gene expression (measured by means of quantitative PCR) were also attenuated in skin fibroblasts before the appearance of depression. Interestingly, circadian entrainment is not altered in a model of depression (induced by methylmercury prenatal exposure) that responds to FLX. Altogether, our results suggest that alterations in circadian entrainment of spontaneous activity, and possibly clock gene expression in fibroblasts, may predict the onset of depression and the response to FLX in patients.
Heritability estimates of the Big Five personality traits based on common genetic variants
Authors: Power R A , Pluess M
Published: July 2015

According to twin studies, the Big Five personality traits have substantial heritable components explaining 40–60% of the variance, but identification of associated genetic variants has remained elusive. Consequently, knowledge regarding the molecular genetic architecture of personality and to what extent it is shared across the different personality traits is limited. Using genomic-relatedness-matrix residual maximum likelihood analysis (GREML), we here estimated the heritability of the Big Five personality factors (extraversion, agreeableness, conscientiousness, neuroticism and openness for experience) in a sample of 5011 European adults from 527 469 single-nucleotide polymorphisms across the genome. We tested for the heritability of each personality trait, as well as for the genetic overlap between the personality factors. We found significant and substantial heritability estimates for neuroticism (15%, s.e.=0.08, P=0.04) and openness (21%, s.e.=0.08, P<0.01), but not for extraversion, agreeableness and conscientiousness. The bivariate analyses showed that the variance explained by common variants entirely overlapped between neuroticism and openness (rG=1.00, P <0.001), despite low phenotypic correlation (r=−0.09, P <0.001), suggesting that the remaining unique heritability may be determined by rare or structural variants. As far as we are aware of, this is the first study estimating the shared and unique heritability of all Big Five personality traits using the GREML approach. Findings should be considered exploratory and suggest that detectable heritability estimates based on common variants is shared between neuroticism and openness to experiences.
Weak aurophilic interactions in a series of Au(iii) double salts
Authors: Chernyshev Alexander N. , Chernysheva Maria V. , Hirva Pipsa , Kukushkin Vadim Yu. , Haukka Matti
Published: July 2015

In this work, several new examples of rare AuIII⋯AuIIIaurophilic contacts are reported.
Determination and analytical validation of creatinine content in serum using image analysis by multivariate transfer calibration procedures
Authors: de Lelis Medeiros de Morais Camilo , Gomes de Lima Kássio Michell
Published: July 2015

The main objective of this study was to explore the feasibility of image analysis and PLS regression using calibration model transfer technique in quantitative analysis of creatinine.
FeV2S4as a high capacity electrode material for sodium-ion batteries
Authors: Krengel Markus , Adelhelm Philipp , Klein Franziska , Bensch Wolfgang
Published: July 2015

FeV2S4synthesizedviaa solid state reaction showing a high area capacity of 2.7 mA h cm−2for sodium ion batteries at room temperature.
A novel quaternary solid solution photo-absorber material for photoelectrochemical hydrogen generation
Authors: Hong Tiantian , Liu Zhifeng , Yan Weiguo , Wang Bo , Zhang Xueqi , Liu Junqi , Wang Junkai , Han Jianhua
Published: July 2015

We report a novel quaternary solid solution (Ag–Cu–Sb–S or ACSS) serving as a photo-absorber material in the photoelectrochemical field for the first time, and ZnO/ACSS nanoarrays exhibited a photocurrent density of 4.45 mA cm−2.
DNA-mediated supercharged fluorescent protein/graphene oxide interaction for label-free fluorescence assay of base excision repair enzyme activity
Authors: Wang Zhen , Li Yong , Li Lijun , Li Daiqi , Huang Yan , Nie Zhou , Yao Shouzhuo
Published: July 2015

The interaction between supercharged green fluorescent protein (ScGFP) and graphene oxide (GO) as well as the resulting quenching effect of GO on ScGFP were investigated.
Iron-catalyzed direct α-arylation of ethers with azoles
Authors: Correa Arkaitz , Fiser Béla , Gómez-Bengoa Enrique
Published: July 2015

The direct α-arylation of cyclic and acyclic ethers with azoles has been achieved, which features a novel iron-catalyzed cross-dehydrogenative coupling (CDC) process.
Facile synthesis of multiple enzyme-containing metal–organic frameworks in a biomolecule-friendly environment
Authors: Wu Xiaoling , Ge Jun , Yang Cheng , Hou Miao , Liu Zheng
Published: July 2015

A facile and simple method was proposed for the synthesis of multi-enzyme-containing metal–organic frameworks.
New ionic liquids based on the complexation of dipropyl sulfide and AlCl3for electrodeposition of aluminum
Authors: Fang Youxing , Jiang Xueguang , Sun Xiao-Guang , Dai Sheng
Published: July 2015

A new kind of ionic liquid based on complexation of dipropyl sulfide (DPS) and AlCl3has been prepared. This new ionic liquid can be successfully used as an electrolyte for electrodeposition of aluminum.
Recovering ultraclean lignins of controlled molecular weight from Kraft black-liquor lignins
Authors: Klett A. S. , Chappell P. V. , Thies M. C.
Published: July 2015

By operating in a region of liquid–liquid equilibrium, hot acetic acid–water mixtures can be used to simultaneously clean, fractionate, and solvate Kraft black-liquor lignins.
The pivotal role of oxygen interstitials in the dynamics of growth and movement of germanium nanocrystallites
Authors: Chen K. H. , Wang C. C. , Lai W. T. , George T. , Li P. W.
Published: July 2015

An unusual “symbiotic” chain reaction is activated by oxygen interstitials acting in concert with Ge and Si interstitials, inducing the coalescence of sparsely-distributed Ge nanocrystallites and their autonomous migration within SiO2/Si3N4layers.
Titanocene dichloride and poly(o-aminophenol) as a new heterogeneous cooperative catalysis system for three-component Mannich reaction
Authors: Zhu Xuyang , Chen Chun , Yu Binxun , Wu Ya , Zhang Guofang , Zhang Weiqiang , Gao Ziwei
Published: July 2015

A heterogeneous binary acid system featuring an organometallic precusor, titanocene dichloride, and poly(o-aminophenol) as a cooperative Brønsted acid supporter was developed.
One-step DGC assembly and structural characterization of a hairy particle zeolite-like organic–inorganic hybrid as an efficient modifiable catalytic material
Authors: Zhou Dan , Xu Jun , Deng Jiejie , Wei Xianlong , Lu Xinhuan , Chu Xing , Deng Feng , Xia Qinghua
Published: July 2015

Synthesis of a hairy particle zeolite-like organic–inorganic hybrid with a high organic content by one-step DGC assembly of organic Si, inorganic Si and other inorganic species without any organic template.
Reduced graphene oxide anchored Cu(OH)2as a high performance electrochemical supercapacitor
Authors: Pramanik Atin , Maiti Sandipan , Mahanty Sourindra
Published: July 2015

A Cu(OH)2@RGO symmetric supercapacitor cell shows an excellent energy density and power density (84.5 Wh kg−1at 550 W kg−1).
Osmium(ii) polypyridyl polyarginine conjugate as a probe for live cell imaging; a comparison of uptake, localization and cytotoxicity with its ruthenium(ii) analogue
Authors: Byrne Aisling , Dolan Ciarán , Moriarty Roisin D. , Martin Aaron , Neugebauer Ute , Forster Robert J. , Davies Anthony , Volkov Yuri , Keyes Tia E.
Published: July 2015

The first example of a cell permeable osmium(ii) polypyridyl peptide conjugate [Os(bpy)2(pic)arg8]10+ employed as an contrast agent for live cell imaging is reported.
Recognition of DNA/RNA bulges by antimicrobial and antitumor metallohelices
Authors: Malina Jaroslav , Scott Peter , Brabec Viktor
Published: July 2015

Bulged structures in nucleic acids recognized and stabilized by helical bimetallic species have been identified and have been proposed to be linked to the biological activity of these species.
DFT analysis into the intermediates of nickel pyridinethiolate catalysed proton reduction
Authors: Virca Carolyn N. , McCormick Theresa M.
Published: July 2015

The catalytic cycle of the water reduction catalyst, nickel pyridine 2-thiolate, has been investigated using Density Functional Theory.
Semiconducting quaternary chalcogenide glasses as new potential thermoelectric materials: an As–Ge–Se–Sb case
Authors: Dahshan A. , Sharma Pankaj , Aly K. A.
Published: July 2015

The performance of chalcogenides as thermoelectric materials may be improved via complex structures, impurities, disorder etc.
Biphenyl-2,4,6,3′,5′-pentacarboxylic acid as a tecton for six new Co(ii) coordination polymers: pH and N-donor ligand-dependent assemblies, structure diversities and magnetic properties
Authors: Han Min-Le , Bai Liang , Tang Ping , Wu Xue-Qian , Wu Ya-Pan , Zhao Jun , Li Dong-Sheng , Wang Yao-Yu
Published: July 2015

Six new Co(ii) coordination polymers have been synthesized and characterized. The N-donor co-ligands and pH value have an effect on the final structures.
Bismuth coordination networks containing deferiprone: synthesis, characterisation, stability and antibacterial activity
Authors: Burrows Andrew D. , Jurcic Monika , Mahon Mary F. , Pierrat Sandrine , Roffe Gavin W. , Windle Henry J. , Spencer John
Published: July 2015

Bismuth–dicarboxylate–deferiprone coordination networks release the iron overload drug deferiprone on treatment with PBS and demonstrate antibacterial activity against H. pylori.
New ceramic electrodes allow reaching the target current density in bioelectrochemical systems
Authors: Massazza Diego , Parra Rodrigo , Busalmen Juan P. , Romeo Hernán E.
Published: July 2015

New ceramic electrodes outweigh typical carbonaceous materials as anodes for microbial electrocatalysis.
Correction: Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes
Authors: Li Baolong , Tian Sicong , Liu Xu , He Canxia , Ding Zhongqing , Shan Yujuan
Published: July 2015

Correction for ‘Sulforaphane protected the injury of human vascular endothelial cell induced by LPC through up-regulating endogenous antioxidants and phase II enzymes’ by Baolong Li et al., Food Funct., 2015, DOI: 10.1039/c5fo00438a.
Large-scale synthesis of water-soluble CuInSe2/ZnS and AgInSe2/ZnS core/shell quantum dots
Authors: Kang Xiaojiao , Yang Yanchun , Huang Lijian , Tao Ying , Wang Lan , Pan Daocheng
Published: July 2015

Water-soluble CISe/ZnS and AISe/ZnS core/shell QDs with a maximum PLQY of 23.3% have been prepared in an electric pressure cooker.
Speciation of inorganic arsenic in particulate matter by combining HPLC/ICP-MS and XANES analyses
Authors: Tirez K. , Vanhoof C. , Peters J. , Geerts L. , Bleux N. , Adriaenssens E. , Roekens E. , Smolek S. , Maderitsch A. , Steininger R. , Göttlicher J. , Meirer F. , Streli C. , Berghmans P.
Published: July 2015

Inorganic arsenic species in ambient particulate matter (PM10 and PM2.5) have been determined in an urban area, in the vicinity of a metallurgical industrial plant.
Investigation of the electrical properties of standard and low-gas-flow ICPs using novel probes for the direct measurements of RF voltage and current in the load coil and the corresponding calculation of the ICP power
Authors: Voronov M. , Hoffmann V. , Birus D. , Engelhard C. , Buscher W.
Published: July 2015

For the first time RF voltage and current were measured directly at the ICP load coil.
Optomechanical measurement of the stiffness of single adherent cells
Authors: Park Kidong , Mehrnezhad Ali , Corbin Elise A. , Bashir Rashid
Published: July 2015

We demonstrate a novel optomechanical technique to characterize the stiffness of single adherent cells on a substrate in a non-invasive manner.
Dispersedly embedded loading of Fe3O4nanoparticles into graphene nanosheets for highly efficient and recyclable removal of heavy metal ions
Authors: Zhou Gang , Xu Xiaoyong , Zhu Wenchang , Feng Bing , Hu Jingguo
Published: July 2015

The RGO/Fe3O4composites exhibit an extraordinary ability for scavenging Cr(vi) and the favorable magnetism to perform magnetic recycling.
The rhodium complex of bis(diphenylphosphinomethyl)dopamine-coated magnetic nanoparticles as an efficient and reusable catalyst for hydroformylation of olefins
Authors: Shaikh Mohammed Nasiruzzaman , Bououdina Mohamed , Jimoh Abiola Azeez , Aziz Md. Abdul , Helal Aasif , Hakeem Abbas Saeed , Yamani Zain H. , Kim Tae-Jeong
Published: July 2015

MNPs functionalized with new bis(diphenylphosphinomethyl)dopamine (bpd) for hydroformylation reaction.
Controlled synthesis of a highly dispersed BiPO4 photocatalyst with surface oxygen vacancies
Authors: Wei Zhen , Liu Yanfang , Wang Jun , Zong Ruilong , Yao Wenqing , Wang Juan , Zhu Yongfa
Published: July 2015

A highly dispersed BiPO4 photocatalyst with surface oxygen vacancies was synthesized via a solvothermal–calcination method.
Kinetically controlled synthesis of large-scale morphology-tailored silver nanostructures at low temperature
Authors: Zhang Ling , Zhao Yuda , Lin Ziyuan , Gu Fangyuan , Lau Shu Ping , Li Li , Chai Yang
Published: July 2015

Large-scale morphology-tailored Ag nanostructures capped by cetylpyridinium chloride were produced by reducing AgCl precursors with ascorbic acid at 45 °C in water, including cubes, wires, triangular bipyramids/cubes with twinned boundaries, and decahedra.
High-resolution electrohydrodynamic jet printing of small-molecule organic light-emitting diodes
Authors: Kim Kukjoo , Kim Gyeomuk , Lee Bo Ram , Ji Sangyoon , Kim So-Yun , An Byeong Wan , Song Myoung Hoon , Park Jang-Ung
Published: July 2015

An electrohydrodynamic jet (e-jet) printed high-resolution (pixel width of 5 μm) small-molecule organic light-emitting diode (OLED) is demonstrated.
Cytotoxicity, tumor targeting and PET imaging of sub-5 nm KGdF4 multifunctional rare earth nanoparticles
Authors: Cao Xinmin , Cao Fengwen , Xiong Liqin , Yang Yang , Cao Tianye , Cai Xi , Hai Wangxi , Li Biao , Guo Yixiao , Zhang Yimin , Li Fuyou
Published: July 2015

MicroPET/CT images showed the uptake of sub-5 nm KGdF4 rare earth nanoparticles in U87MG and H1299 tumors.
ω-Transaminases for the amination of functionalised cyclic ketones
Authors: Richter N. , Simon R. C. , Lechner H. , Kroutil W. , Ward J. M. , Hailes H. C.
Published: July 2015

The potential of several enantiocomplementary ω-transaminases (ω-TAms) for the amination of cyclic ketones has been investigated.
Photochemically-induced C–C bond formation between tertiary amines and nitrones
Authors: Itoh Kennosuke , Kato Ryo , Kinugawa Daito , Kamiya Hideaki , Kudo Ryuki , Hasegawa Masayuki , Fujii Hideaki , Suga Hiroyuki
Published: July 2015

Photoexcited nitrones serve as excellent electron acceptors as well as radical acceptors in the presence of tertiary amines to give β-amino hydroxylamines via photochemically-induced direct sp3 C–H functionalization of the tertiary amines.
One-pot synthesis of 1,3-enynes with a CF3 group on the terminal sp2 carbon by an oxidative Sonogashira cross-coupling reaction
Authors: Ikeda Akari , Omote Masaaki , Kusumoto Kana , Tarui Atsushi , Sato Kazuyuki , Ando Akira
Published: July 2015

One-pot synthesis of 1,3-enynes with a CF3 group on the terminal sp2 carbon was achieved by an oxidative Sonogashira cross-coupling reaction with (E)-trimethyl(3,3,3-trifluoroprop-1-enyl)silane.
PGMA-based starlike polycations with flanking phenylboronic acid groups for highly efficient multifunctional gene delivery systems
Authors: Li Rui-Quan , Song Hai-Qing , Xu Fu-Jian
Published: July 2015

A simple strategy to prepare starlike PGMA-based vectors with phenylboronic acid groups was proposed for multifunctional gene delivery systems.
White light-emitting diodes based on an all-phosphorescent supramolecular polymer
Authors: Liang Aihui , Dong Sheng , Zhu Xiuhui , Huang Fei , Cao Yong
Published: July 2015

Novel white light-emitting supramolecular phosphorescent polymers were first synthesized through an efficient host–guest interaction, and their performances can be readily adjusted by varying the monomer ratio. The present work provides an effective way to afford high-performance solution-processable white electroluminescent emitters.
Organocatalysis by hydrogen-bonding: a new approach to controlled/living polymerization of α-amino acid N-carboxyanhydrides
Authors: Zhao Wei , Gnanou Yves , Hadjichristidis Nikos
Published: July 2015

Hydrogen-bonding organocatalytic controlled/living ROP of α-amino acid N-carboxyanhydrides.
UV light-initiated RAFT polymerization induced self-assembly
Authors: Liu Zhenzhong , Zhang Gongjun , Lu Wei , Huang Youju , Zhang Jiawei , Chen Tao
Published: July 2015

Reversible addition–fragmentation chain transfer (RAFT) polymerization induced self-assembly (PISA) initiated by UV light is exploited as a new strategy to prepare polymeric nanomicelles at room temperature.
Synthesis and reactivity of bis(2,2,2-trifluoroethyl)cyclopropane-1,1-dicarboxylates
Authors: Armstrong Erin L. , Kerr Michael A.
Published: July 2015

Diazo-bis-222-trifluoroethylmalonate was treated with a variety of alkenes under the influence of rhodium catalysis to yield the corresponding bis(2,2,2-trifluoroethyl)cyclopropane-1,1-dicarboxylates in good yields.
New efficient and recyclable catalysts for the synthesis of di- and tri-glycerol carbonates
Authors: Aresta M. , Dibenedetto A. , di Bitonto L.
Published: July 2015

Mixed oxides have been used for the conversion of glycerol into DGDC and DGTC using either DMC or urea.
Performance of hierarchical HZSM-5 zeolites prepared by NaOH treatments in the aromatization of glycerol
Authors: Xiao Weiyin , Wang Fei , Xiao Guomin
Published: July 2015

A study on the aromatization of glycerol over hierarchical ZSM-5 zeolites modified by alkaline treatment.
Synthesis, growth, spectral studies, first-order molecular hyperpolarizability and Hirshfeld surface analysis of isonicotinohydrazide single crystals
Authors: Meenatchi V. , Meenakshisundaram SP.
Published: July 2015

Single crystals of (E)-N′-((4-fluorophenyl)(phenyl)methylene)isonicotinohydrazide dihydrate were grown by the slow evaporation solution growth technique.
Preparative separation of a challenging anthocyanin from Lycium ruthenicum Murr. by two-dimensional reversed-phase liquid chromatography/hydrophilic interaction chromatography
Authors: Jin Hongli , Zhao Jianqiang , Zhou Weijia , Shen Aijin , Yang Fan , Liu Yanfang , Guo Zhimou , Zhang Xiuli , Tao Yanduo , Peng Xiaojun , Liang Xinmiao
Published: July 2015

The preparative separation of anthocyanins by HPLC often suffers from insufficient separation selectivity.
Preparation of SiO2 aerogel from rice husk ash
Authors: Cui Sheng , Yu Shu-wen , Lin Ben-lan , Shen Xiao-dong , Gu Danming
Published: July 2015

Silica was leached from rice husk ash as sodium silicate by NaOH treatment.
Spectroscopic and molecular docking evidence of aspirin and diflunisal binding to DNA: a comparative study
Authors: Husain Mohammed Amir , Rehman Sayeed Ur , Ishqi Hassan Mubarak , Sarwar Tarique , Tabish Mohammad
Published: July 2015

Deciphering the binding mode between aspirin/diflunisal with Ct-DNA.
Calf thymus histone-conjugated magnetic poly(2-oxoethyl methacrylate) microspheres for affinity isolation of anti-histone IgGs from the blood serum of patients with systemic lupus erythematosus
Authors: Horák D. , Plichta Z. , Starykovych M. , Myronovskij S. , Kit Y. , Chopyak V. , Stoika R.
Published: July 2015

Affinity isolation of anti-histone immunoglobulins from blood serum of systemic lupus erythematosus patients using histone-conjugated magnetic poly(2-oxoethyl methacrylate) microspheres (IO-iron oxide, HIS-histone).
Thermal property of an aggregation-induced emission fluorophore that forms metal–ligand complexes with Zn(ClO4)2 of salicylaldehyde azine-functionalized polybenzoxazine
Authors: Mohamed Mohamed Gamal , Lin Ruey-Chorng , Tu Jia-Huei , Lu Fang-Hsien , Hong Jin-Long , Jeong Kwang-Un , Wang Chih-Feng , Kuo Shiao-Wei
Published: July 2015

A salicylaldehyde azine-functionalized benzoxazine monomer formed zinc ion complexes not only improved the thermal properties but also facilitated ring-opening polymerization.
Synthesis of Nd3+/Yb3+ sensitized upconversion core–shell nanocrystals with optimized hosts and doping concentrations
Authors: Wang Kun , Qincheng Wanli , Zhang Yong , Qiao Ru , Li Sheng , Li Zhengquan
Published: July 2015

Dual Nd3+/Yb3+ sensitized upconversion core–shell nanocrystals with strong upconversion emissions under both 808 nm and 980 nm excitation are developed.
A highly selective fluorescent chemosensor based on a quinoline derivative for zinc ions in pure water
Authors: Choi Ye Won , Lee Jae Jun , Kim Cheal
Published: July 2015

A water-soluble fluorescent sensor with a low detection limit could be used to detect and quantify Zn2+in water samples.
Synthesis of copper oxide/reduced graphene oxide nanocomposite and its enhanced catalytic activity towards reduction of 4-nitrophenol
Authors: Sarkar Chandrama , Dolui Swapan K.
Published: July 2015

Graphene oxide (GO) and its derivatives have attracted extensive interest in many fields, including catalytic chemistry, organic synthesis, and electrochemistry.
Metal-free one-pot synthesis of 1,3-diazaheterocyclic compounds via I2-mediated oxidative C–N bond formation
Authors: Tian Xianhai , Song Lina , Li Ertong , Wang Qiang , Yu Wenquan , Chang Junbiao
Published: July 2015

A variety of 1,3-diazaheterocyclic compounds, including quinazolinones, benzimidazoles, and cyclic amidines, were readily synthesized through this metal-free one-pot annulation reaction.
Synthesis of tetrazoles via isocyanide-based reactions
Authors: Maleki Ali , Sarvary Afshin
Published: July 2015

This article provides an overview of the contributions and advances in the synthesis of tetrazoles via isocyanide-based reactions.
Improved biodegradation of total organic carbon and polychlorinated biphenyls for electricity generation by sediment microbial fuel cell and surfactant addition
Authors: Xu X. , Zhao Q. L. , Wu M. S.
Published: July 2015

The biodegradation of total organic carbon (TOC) and polychlorinated biphenyls (PCBs) in sediment was studied in different treatments.
H-Rubies, a new family of red emitting fluorescent pH sensors for living cells
Authors: Despras Guillaume , Zamaleeva Alsu I. , Dardevet Lucie , Tisseyre Céline , Magalhaes Joao Gamelas , Garner Charlotte , De Waard Michel , Amigorena Sebastian , Feltz Anne , Mallet Jean-Maurice , Collot Mayeul
Published: July 2015

H-Rubies is a family of pH probes that display a bright red fluorescence upon acidification. They have been used as molecular form to monitor mitochondrial acidification and as functionalised forms to provide ratiometric systems to measure phagosomal and endosomal pH in macrophages.
Copper coordination polymers from cavitand ligands: hierarchical spaces from cage and capsule motifs, and other topologies
Authors: Thorp-Greenwood Flora L. , Ronson Tanya K. , Hardie Michaele J.
Published: July 2015

Copper coordination polymers from cavitand ligands are reported including networked cage-motif structures, one of which takes up C60 from solution.
A crystalline sponge based on dispersive forces suitable for X-ray structure determination of included molecular guests
Authors: Sanna Elena , Escudero-Adán Eduardo C. , Bauzá Antonio , Ballester Pablo , Frontera Antonio , Rotger Carmen , Costa Antonio
Published: July 2015

A new organic material assembled by dispersive forces exhibits stable one-dimensional channels suitable as the solid support in X-ray structural studies by the crystalline sponge method.
Light-driven bending of diarylethene mixed crystals
Authors: Ohshima Satoko , Morimoto Masakazu , Irie Masahiro
Published: July 2015

The bending response of mixed crystals by selective photoisomerization revealed that the local shape change of each molecule is additively linked to the macroscopic deformation of the crystals.
Nuclear stiffening and chromatin softening with progerin expression leads to an attenuated nuclear response to force
Authors: Booth Elizabeth A. , Spagnol Stephen T. , Alcoser Turi A. , Dahl Kris Noel
Published: July 2015

Progerin, a mutant form of the nuclear protein lamin A, is associated with the premature aging disorder Hutchinson-Gilford progeria syndrome. Progerin expression leads to a variety of changes in nuclear structure, mechanics and mechano-responsiveness.
In situ co-pyrolysis fabrication of CeO2/g-C3N4 n–n type heterojunction for synchronously promoting photo-induced oxidation and reduction properties
Authors: Tian Na , Huang Hongwei , Liu Chengyin , Dong Fan , Zhang Tierui , Du Xin , Yu Shixin , Zhang Yihe
Published: July 2015

CeO2/g-C3N4 n–n type heterojunction was successfully constructed via a facile in situ co-pyrolysis route by employing Ce(IO3)3 and melamine as precursors. It exhibits high photo-induced oxidation and reduction properties for degradation of phenol, NO removal and hydrogen evolution.
Heading towards novel superior silicon-based lithium-ion batteries: ultrasmall nanoclusters top-down dispersed over synthetic graphite flakes as binary hybrid anodes
Authors: Huang Yao-Hui , Chang Chih-Tse , Bao Qi , Duh Jenq-Gong , Chueh Yu-Lun
Published: July 2015

Novel scalable ultranano-Si particlesviatop-down dispersion have been developed originally to achieve high performance Si-based anodes with economic benefits heading toward industrial feasibility.
A multifunctional C + epoxy/Ag-paint cathode enables efficient and stable operation of perovskite solar cells in watery environments
Authors: Wei Zhanhua , Zheng Xiaoli , Chen Haining , Long Xia , Wang Zilong , Yang Shihe
Published: July 2015

C + epoxy/Ag paint-based perovskite solar cells are not only efficient (∼11%) but also waterproof.
A highly efficient zinc catalyst for selective electroreduction of carbon dioxide in aqueous NaCl solution
Authors: Quan Fengjiao , Zhong Dan , Song Hancheng , Jia Falong , Zhang Lizhi
Published: July 2015

A low-cost nanoscale zinc catalyst, prepared by a facile electrochemical strategy, exhibits high activity toward electrochemical reduction of CO2 to CO with up to 93% Faraday efficiency in aqueous NaCl solution.
Nickel-rich layered LiNi1−xMxO2(M = Mn, Fe, and Co) electrocatalysts with high oxygen evolution reaction activity
Authors: Augustyn Veronica , Therese Soosairaj , Turner Travis C. , Manthiram Arumugam
Published: July 2015

The first systematic investigation of a family of Ni-rich layered lithium oxides reveals tunable catalytic activity.
Boosting the oxygen reduction reaction mechanisms in IT-SOFC cathodes by catalytic functionalization
Authors: Navarrete L. , Solís C. , Serra J. M.
Published: July 2015

A robust LSM-GDC composite was used as a backbone electrode for the infiltration of different catalysts, dispersed as oxide nanoparticles after firing.
A chitosan modified nickel oxide platform for biosensing applications
Authors: Solanki Pratima R. , Patel Manoj Kumar , Ali Md. Azahar , Malhotra B. D.
Published: July 2015

We present a highly sensitive and selective electrochemical sandwich immunosensor (the analyte is “sandwiched” between two antibodies) based on chitosan modified nickel oxide nanoparticles for the detection of Vibrio cholerae.
Autophagy in resin monomer-initiated toxicity of dental mesenchymal cells: a novel therapeutic target of N-acetyl cysteine
Authors: Zhu Lingxin , Zhang Jie , Xiao Lan , Liu Shan , Yu Jingjing , Chen Weihai , Zhang Xianzheng , Peng Bin
Published: July 2015

A proposed schematic model of autophagy involvement in resin monomer-initiated toxicity of dental mesenchymal cells and as a novel therapeutic target of NAC.
Eu3+ luminescence from different sites in a scheelite-type cadmium molybdate red phosphor with vacancies
Authors: Guzik M. , Tomaszewicz E. , Guyot Y. , Legendziewicz J. , Boulon G.
Published: July 2015

Spectroscopy of Eu3+ ions in Cd1−3xEu2x□xMoO4, points out the three main non-equivalent symmetry sites very close to each other, due to the subtle differences in emission. Eu3+ ions in this almost ideal red light phosphor possess S4 point symmetry.