bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of the lung microbiome on antibiotic susceptibility of cystic fibrosis pathogens
Authors: Vandeplassche Eva , Tavernier Sarah , Coenye Tom , Crabbé Aurélie
Published: July 2019

The lungs of patients with cystic fibrosis (CF) are colonised by a microbial community comprised of pathogenic species, such asPseudomonas aeruginosaandStaphylococcus aureus, and microorganisms that are typically not associated with worse clinical outcomes (considered as commensals). Antibiotics directed at CF pathogens are often not effective and a discrepancy is observed between activity of these agentsin vitroand in the patient. This review describes how interspecies interactions within the lung microbiome might influence the outcome of antibiotic treatment targeted at common CF pathogens. Protective mechanisms by members of the microbiome such as antibiotic degradation (indirect pathogenicity), alterations of the cell wall, production of matrix components decreasing antibiotic penetration, and changes in metabolism are discussed. Interspecies interactions that increase bacterial susceptibility are also addressed. Furthermore, we discuss how experimental conditions, such as culture media, oxygen levels, incorporation of host–pathogen interactions, and microbial community composition may influence the outcome of microbial interaction studies related to antibiotic activity. Hereby, the importance to createin vitroconditions reflective of the CF lung microenvironment is highlighted. Understanding the role of the CF lung microbiome in antibiotic efficacy may help find novel therapeutic and diagnostic approaches to better tackle chronic lung infections in this patient population.
Demographics and survival of patients with idiopathic pulmonary fibrosis in the FinnishIPF registry
Authors: Kaunisto Jaana , Salomaa Eija-Riitta , Hodgson Ulla , Kaarteenaho Riitta , Kankaanranta Hannu , Koli Katri , Vahlberg Tero , Myllärniemi Marjukka
Published: July 2019

Idiopathic pulmonary fibrosis (IPF) is characterised by unpredictable disease course and poor survival. After the introduction of novel antifibrotic drugs, the prognosis of patients with IPF is probably changing.

FinnishIPF, a nationwide registry of carefully characterised patients, was initiated in Finland in 2011. For the data analysis, we included 453 incident IPF patients diagnosed during 2011–2015. In this study, we describe the demographics and prognosis of these real-life patients.

The median overall survival time of registered IPF patients was 4.5 years. The transplant-free survival at 1, 2, 3, 4 and 5 years was 95%, 83%, 70%, 58% and 45%, respectively. Smoking did not have any effect on survival. 117 (26%) patients received pirfenidone or nintedanib. Patients who received ≥6 months of treatment had better survival compared with those who did not receive treatment but this difference disappeared after age adjustment. The transplantation rate was 3%.

Although IPF is diagnosed in Finland at a older age, the prognosis is better than expected due to a relatively well preserved lung function at diagnosis. Age and pulmonary function were identified as independent predictors of survival in the entire IPF patient population as well as in patients who had received antifibrotic treatment.
President's Page
Authors: Fomel Sergey
Published: July 2019

I moved to the United States from Russia half of my lifetime ago and became a naturalized citizen 15 years later. The naturalization ceremony was a moving experience. The largest auditorium of Trinity University in San Antonio, Texas, was filled with a thousand people from 90 different countries. I could not help admiring my newly adopted country, which was opening its doors to people of so many diverse backgrounds while asking them for allegiance not to the ruling party or the ethnic majority but to the Constitution, which equally protects the rights of everyone.
Neural networks for geophysicists and their application to seismic data interpretation
Authors: Peters Bas , Haber Eldad , Granek Justin
Published: July 2019

There has been a surge of interest in neural networks for the interpretation of seismic images over the last few years. Network-based learning methods can provide fast and accurate automatic interpretation, provided that there are many training labels. We provide an introduction to the field for geophysicists who are familiar with the framework of forward modeling and inversion. We explain the similarities and differences between deep networks and other geophysical inverse problems and show their utility in solving problems such as lithology interpolation between wells, horizon tracking, and segmentation of seismic images. The benefits of our approach are demonstrated on field data from the Sea of Ireland and the North Sea.
Frequency-dependent seismic analysis: Data processing, modeling, and interpretation
Authors: Shen Yi , Bao Kui , Foster Doug , Kumar Dhananjay , Innanen Kris , Chapman Mark , Hu Wenyi , Zhu Tieyuan , Wang Min , Gurevich Boris , Holt1 Rune M. , Zeng Hongliu
Published: July 2019

A one-day postconvention workshop held during the 2018 SEG Annual Meeting in Anaheim, California, focused on seismic attenuation model building and compensation through imaging in the morning and on frequency-dependent seismic interpretation and rock physics in the afternoon. The workshop was organized by Dhananjay Kumar (BP), Yi Shen (Shell), Kui Bao (Shell), Mark Chapman (University of Edinburgh), Doug Foster (The University of Texas at Austin), Wenyi Hu (Advanced Geophysical Tech Inc.), and Tieyuan Zhu (Pennsylvania State University). The main topics discussed were: attenuation and Q model building using seismic, vertical seismic profiling, well-log and core data, seismic attenuation compensation, rock-physics modeling, seismic modeling, and frequency-dependent seismic interpretation.
Surface expression marker profile in colon cancer cell lines and sphere-derived cells suggests complexity in CD26+cancer stem cells subsets
Authors: Vázquez-Iglesias Lorena , Barcia-Castro Leticia , Rodríguez-Quiroga Marta , de la Cadena María Páez , Rodríguez-Berrocal Javier , Cordero Oscar J.
Published: July 2019

Taking advantage of eight established cell lines from colorectal cancer patients at different stages of the disease and the fact that all of them could form spheres, cell surface biomarkers of cancer stem cells and epithelial-mesenchymal transition were tested. The aim was to investigate cancer stem cells and metastatic stem cells in order to provide functional characterization of circulating tumor cells and promote the development of new anti-metastatic therapies.

Our model showed an important heterogeneity in EpCAM, CD133, CD44, LGR5, CD26, and E-cadherin expression. We showed the presence of a subset of E-cadherin+ (some cells being E-cadherinhigh) expressing CD26+ (or CD26high) together with the well-known CSC markers LGR5 and EpCAMhigh, sometimes in the absence of CD44 or CD133. The already described CD26+/E-cadherinlow or negative and CD26+/EpCAM−/CD133− subsets were also present. Cell division drastically affected the expression of all markers, in particular E-cadherin, so new-born cells resembled mesenchymal cells in surface staining.

CD26 and/or dipeptidyl peptidase 4 inhibitors have already shown anti-metastatic effects in pre-clinical models, and the existence of these CD26+ subsets may help further research against cancer metastasis.
A Framework to Evaluate Devices That Assess Physical Behavior
Authors: Keadle Sarah Kozey , Lyden Kate A. , Strath Scott J. , Staudenmayer John W. , Freedson Patty S.
Published: July 2019

Body-worn devices that estimate physical behavior have tremendous potential to address key research gaps. However, there is no consensus on how devices and processing methods should be developed and evaluated, resulting in large differences in summary estimates and confusion for end users. We propose a phase-based framework for developing and evaluating devices that emphasizes robust validation studies in naturalistic conditions.
The Concept of Trials in Absentia in International Criminal Law and the Special Tribunal for Lebanon: An Overview
Authors: Guha Shouvik Kumar
Published: July 2019

Trials in absentia have always been quite a contentious source of controversies in international criminal law, especially given the nature of crimes that result into these trials and given the question regarding what can be an acceptable standard of legal due process that ought to be adhered to in course of such trials. Throughout this paper, the author has sought to present an overview of the concept as it is prevalent in the current domestic and international legal scenarios. An effort has also been made to portray the range and acceptability of the arguments that are advanced by the proponents and detractors of the notion of accepting this category of trials as a matter of course to combat international and domestic crimes. The varying approaches of common law and civil law

jurisdictions vis-à-vis this subject-matter has also been examined, together with the practices prevalent in renowned international tribunals such as International Criminal Tribunal for the former Yugoslavia [hereinafter referred to as “ICTY”], the International Criminal Tribunal for Rwanda [hereinafter referred to as “ICTR”] and the International Criminal Court [hereinafter referred to as “ICC”]. Finally, the author has looked into the manner in which the question of the validity of such trials has once again come to the forefront owing to its acceptance by the Special Tribunal for Lebanon.
Moral Rights: International Framework and Indian Approach
Authors: Agarwal Nikhil , Ojha Vinayak
Published: July 2019

In the wake of increasing globalization and technical advancements in the digital field, the dissemination of creative work has become easier than ever. However, this development has come with its own set of challenges, particularly for Intellectual Property Law, as most of online transfer of information is unregulated. Digitalization has lead to the imminent need for standardized and stringent protection of an author‟s work. While this protection is mainly conceived as commercial right of the author on his work, there is another fundamental element to it, which is equally important and cannot be neglected, i.e., moral rights. These rights include right of attribution and integrity and are so inextricably related, that they stay with the author, even after transfer of economic rights on the work. In order to ensure effective globalized protection, there is a requirement for minimum standards of protection in all domestic laws, as was provided in the TRIPS agreement. This paper analyzes the Moral Rights regime as envisaged by the TRIPS agreement, and the monoist and dualist approaches that have been adopted by different countries. It also analyzes the evolution of moral rights in India.
Working of Section 153A of the Income Tax Act, 1961: Resolving the Conflict between the Literal Rule of Interpretation and Harmonious Construction
Authors: Jha Srijita , Zaveri Akshay
Published: July 2019

This article ventures into the various interpretations given by the court for the execution of Section 153A of the Income Tax Act, 1961. It has forever been a conflict as to how the particular section has to be interpreted, in order to decide whether the items of regular assessment can be added back in the proceeding under section 153A, after the finalization of assessment. This article tries to decode the mixed opinions of the court with regard to whether it is the literal rule of interpretation or the rule of harmonious construction that would apply to interpret Section 153A. This issue has been dealt with by the authors by analysing the various tools of interpretation of statutes like Literal Rule of Interpretation, reading down of statute as a whole, Rule of Harmonious Construction of statute etc. and their application in various cases based on judicial dicta of the court of law. The authors, based on thorough analysis of Section 153A, based on the language of the provision and the interpretations attached to it by the Judiciary, have tried to resolve the conflict between the Literal rule of interpretation and harmonious construction.
Human Rights Protection in South Asia - A New Road Ahead
Authors: Hazarika Angshuman
Published: July 2019

No Abstract
Curbing Free Speech: Strategic Lawsuits against Public Participation in India
Authors: Katrak Malcolm
Published: July 2019

There has been a sharp increase in the number of suits and legal notices threatening defamation. This substantial increase is due to the corporate companies aiming to stifle public discourse or bona fide criticisms. The apt term coined for defining these lawsuits is SLAPP (Strategic Lawsuits against Public Participation).Not only does this capture the causation, but also the consequences of these lawsuits. Curbing SLAPPs is essential, as it strikes at the root of democracy by not just affecting the defendant with frivolous claims, legal costs and hassles, but by also aiming at choking public discourse. This paper analyzes the issues relating to SLAPP suits and also the consequences of the same by examining various case laws. Thereafter, the author has suggested the need for Anti-SLAPP legislation and has also provided guidelines for formulation of the same.
Book Review: Social Rights Judgments and the Politics of Compliance making it Stick
Authors: Dutta Ashirbani
Published: July 2019

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Pedophilia and Child Sexual Abuse: A Socio Legal Perspective
Authors: Whorra Gargi , Mitra Sudipto
Published: July 2019

Societies worldwide have time and again turned a cold

shoulder towards the heinous offence of child sexual

abuse, until recent times when such hidden skeletons

have walked out of closed cupboards, ranging from

clergymen to the preposterously grotesque Nithari

incident. This paper throws light on the growing foothold

of child sexual abuse in the country by analysing it

through varying dimensions. The paper seeks to examine

the veracity of the situation of children, especially in a

country like India, where the victim, irrespective of his

innocence and fragility, loses his voice in the hullabaloo

of the dogmas of the society. It is for such societal barriers

that the rights of children did not see the light of the day

till the year 2012. This article discusses the attempts made

to check the child sexual abuse which have been made

through legal initiatives and judicial decisions, both at the

national and international level. The paper analyses the

current situation in India with regard to child sexual

abuse, while primarily drawing attention to the recent

Protection of Children from Sexual offences Act, 2012 and

pointing out the lacunae and shortcomings of the Act in

dealing with the peculiar nature of the problem.
Judicial Analysis of the Powers and Functions of the Administrative Tribunals
Authors: Gupta Sanjay , Sharma Smriti
Published: July 2019

Administrative tribunals are adjudicating bodies

established to relieve the traditional courts from the ever

mounting pressure of litigation. This paper makes an

analysis of the powers and functions of the administrative

tribunals as laid down by the judiciary. A series of case

laws are examined at length which debate the nature of

the functions of the tribunals and also elucidate the

importance of tribunals in dispensation of justice.
Understanding Guerrilla Tactics in International Arbitration
Authors: Singh Oberoi Preet
Published: July 2019

This paper delves into some of the major inconveniences caused to the parties engaging in arbitration and seeks to analyze the causes of guerrilla tactics in particular, in order to devise the necessary framework required to control it. Arbitration for dispute resolution has become prominent in the recent times. However, a number of leading arbitrators and practitioners have described the continuing lack of ethical regulation as a potential crisis that threatens the legitimacy of international arbitration. This paper looks at how arbitration can be developed as a means of dispute resolution by providing a level playing field to its parties, thereby restoring its lost credibility. The paper also highlights the need to have an internationally approved code of conduct like the recent International Bar Association (IBA) guidelines, to curb guerrilla tactics in international arbitration.
Marital Rape: An Evaluation of the Patriarchal Injustice in the Criminal Law (Amendment) Act, 2013
Authors: Shivika Choudhary
Published: July 2019

The traditional belief that marriage provides a husband with sole rights over his wife, thereby exempting him from any prosecution for raping his wife, has been the justification for denying a woman the right to consent to sexual intercourse in marriage. Unfortunately, this belief has been a source of subjugation and exploitation of women at the behest of their husbands. Despite recommendations to revoke it, the Criminal Law (Amendment) Act, 2013 has retained the marital exception. The purpose of this article is to examine this dichotomy in the Criminal Law (Amendment) Act, 2013 that punishes rape as such, but does not penalise a husband raping his wife of fifteen years or above.

Employing doctrinal method of research, this article analyses the various discrepancies and ambiguities in the Act of 2013 that perpetuate this culture of oppression and violence. Consent is the antithesis to rape. Thus, having examined the need for a married woman’s right to consent, this note examines the ensuing lacunae that grant legal sanction to child marriages, create an unexplained discrepancy in the punishment for rape, and create variations in the age of consent and the age for availing exception. The recognition of marital rape when spouses live separately and not otherwise appears to be a mysterious distinction. Further, treatment of marital rape
The New Human Rights Paradigm: Convention on the Rights of Persons with Disabilities and its Implementation in India
Authors: Smitha Nizar
Published: July 2019

As any other vulnerable group, the journey of persons with disabilities to be treated as equals with others was long. A change from the tragic picture of helpless beings, who live at the mercy of others to dignified humans, remained as a long cherished desire. The stereotypic social attitude towards persons with disabilities resulted in denial of their basic rights and fundamental freedoms. The widespread exclusion and extreme isolation of persons with disabilities from social institutions was the major reason why it was felt that specific human rights instruments to protect their rights were required. Albeit, the initial fail with unenforceable soft laws, later the human rights perspective started recognizing persons with disabilities as complete human beings with UNCRPD. It introduced a paradigm shift from prejudiced social perception of persons with disabilities as incomplete human beings to complete and equal humans on par with all others. This paper seeks to examine the paradigm shift brought by the United Nations Convention on the Rights of Persons with Disabilities (UNCRPD) and its impact in India within the theoretical framework of international obligation and constitutional perspective.
The Path to Innovation: An Amalgamation of Patent Law and the Dynamic Competition Regime
Authors: Ketana Krishna , Sushma Philip Sosha
Published: July 2019

The purpose of this paper is to identify a method to create a balance between competition laws and the patent protection regime so as to promote innovation. The relationship between competition law and the law relating to intellectual property has long been recognized to be a turbulent one. The traditional perspective adopted towards the relationship between the subjects is that one is opposed to the other; where intellectual property laws encourage and protect monopoly, competition laws seek to curb and control it. This research focuses on the possibility of change from the conventional view relating to competition law and intellectual property law by making the approach to these two subjects more innovation centric. The paper examines these apparently paradoxical disciplines from the perspective of innovation and finds that both intellectual property laws and competition laws have a common objective, which is to increase innovation. This paper undertakes conceptual research in order to develop new concepts and to re-interpret the existing ones. It analyses various economic theories of development and the existing conceptual framework pertaining to competition and patent laws. Finally, the paper suggests amendments in the existing law and proposes a new legal and policy framework that reconciles both the fields so as to promote effective innovation crucial for economic development and trade in India.
Female Intestate Succession under the Hindu Succession Act, 1956: An Epitome of Inequality and Irrationality
Authors: Ayushi Singhal
Published: July 2019

Under the present legal system of India, people from different religions are governed by their own personal laws in matters of inheritance, marriage, separation, guardianship etc. In this regard, the succession in Hindus is governed by the Hindu Succession Act, 1956 (HSA). A peculiar factor of this Act is that it makes a differentiation between the intestate succession of females and males. The female intestate succession is further dependent on the source from which the property was received by the deceased female. The essay analyses the expediency and rationale behind this differentiation at two levels, one, based on the source of the property and the other, based on gender and elucidates how it is irrational and against the principles of equality on various grounds. It also discusses a recent case, which seeks to bring a progressive change in the law related to succession in Hindus.
Determining the Bench Size for Constitutional Adjudication
Authors: Muthu Kumar B
Published: July 2019

The Supreme Court of India acts as a Constitutional Court as well as the highest appellate court. The Constitution imposes mandatory minimum requirements for the strength of the Bench for constitutional adjudication. The apex Court has been criticized for constituting fewer number of Constitution benches, and for delaying the disposal of constitutional matters. Many Constitutional questions are being decided upon by Division benches or Constitutional benches, consisting of merely three members, due to prolific appeals in the Supreme Court. The researcher aims to analyze the question ‘whether the size of the Bench matters for constitutional adjudication?’ The article in the light of Constitutional provisions and the Supreme Court Rules, focuses on the impact of small and large benches, particularly in the highest Court of the land, where constitutional questions are decided upon. The Kesavananda Bharati case has been employed to examine the pros and cons of a large Bench, and the recent NJAC case is analyzed to bring out the problems of a smaller Bench, in overruling the decision of a larger Bench. The researcher therefore, attempts to answer the

* Assistant Professor, SRM School of Law, SRM University, Kattankulathur, Tamil Nadu, India; muthukumarml@gmail.com

question whether a minimum required strength of the Bench in constitutional adjudication is required for the organic development of constitutional jurisprudence in our country.
Reconciling the Pro-Choice Argument with the Anti-Life Rhetoric: Issues in the Indian Context
Authors: Saloni Dukle
Published: July 2019

The debate concerning the woman’s right to choose versus the right to life of the unborn child is centred around the argument, whether one right can be preferred in lieu of another. The law in India simply prohibits abortion unless carried out within twenty weeks, while remaining silent as to the point when life sprouts in the foetus. Further, abortion can only be carried out under specified conditions determined solely by the medical practitioner and not the woman. In this paper, the author argues that prior to foetal viability (twenty-four weeks into the pregnancy, as per studies), the foetus does not classify as a human person and hence, cannot be endowed with the right to life. Thus, the woman’s right to choose when and whether to terminate her pregnancy must not be encroached upon by the State, unless absolutely necessary to prevent harm to her life or health. This outlook, tied in with the implications of denying the woman her right to choose, although pro-choice in nature, does not reflect an anti-life sentiment. The author contends that a pro-choice view does not necessarily impinge upon the foetus’s right to life.
A Critical Analysis of Appointment of Federal Supreme Court Judges in United States of America
Authors: Tripathy Rangin Pallav
Published: July 2019

This research article focuses on a critical analysis of the process by which federal Supreme Court judges in United States of America are appointed. As one of the oldest democracies in the world, the process of judicial appointment in USA has been shaped by centuries of history. The article explores the unique process of judicial appointments in federal Supreme Court of United States where the President and the Senate share the power conjointly, but independently of each other. It looks into the factors which have assumed relevance in the decision making process of both the President and the Senate. The author argues that though the theoretical structure for the appointment of judges in USA is sound, the greatest achievement has been the processes which have developed beyond a direct mandate of law. The conventional practices associated with the process of judicial appointment have brought in a degree of transparency which is elusive in many other countries. The author acknowledges the obvious political flavor in the entire process, but argues that the degree of transparency provides a substantial benefit.
Dharma and the Indian Constitution
Authors: Rajpal Leepakshi , Vats Mayank
Published: July 2019

"Sarva Dharma Sambhavana" is a fundamental precept of Dharma. It is also the predominant thread that runs through several Supreme Court decisions. Was this merely coincidental, or does the Indian Constitution actually imbibe and mirror the principles of Dharma? The relation between Dharma and the Indian Constitution is examined keeping this very fundamental question in mind. The paper is an assertion that the Constitution is framed based on the principles of Dharma and not merely inspired by the western cultures, which the framers of the Constitution failed to realize. Dharma, as per popular notion, is not a singular construct of the Hindu way of life, but is common to all religions. Dharma and religion are two separate entities and are often confused to be one and the same. This paper clarifies these differences and through the descriptive and analytical method, traces the evolution of this concept and its subsequent connect with the laws that govern us. The crux of the paper lies in the fact that law and dharma are strongly interwoven and there is no way the two can be separated.
Business processes of material and technical support of railway transport
Authors: Цевелев Александр , Tsevelev Aleksandr
Published: July 2019

The paper deals with topical issues of implementation of the policy of JSC "Russian Railways" in the field of material and technical support of structural departments of railway transport. According to the results of theoretical studies of the system management of business processes of material and technical support of the railway- road transport, diversification of supply chain activities the concept is formulated and the tree of management goals is developed, as well as the formalization of existing business for the current period- processes of the logistics system
Sentidos y procesos de la Justicia en Equidad en Armenia, Quindío
Authors: Rivera García Jose Luis
Published: July 2019

Pese a más de 10 años de implementación de la Justicia en Equidad en la capital del Quindío, con la primera elección de jueces de paz (El Tiempo, 2002, 29 de septiembre) y el primer nombramiento de conciliadores en equidad (Tribunal Superior de Armenia, 2006), hasta hoy poco se sabe de su desarrollo en la ciudad, pues no hay registro histórico oficial o académico que permita dar cuenta de información sistematizada al respecto, en especial sobre qué significados subyacen a sus procesos y cómo aquellos determinan o influyen en los últimos.Este artículo responde a la investigación que aportó a esas preguntas al describir las nociones y significados de los operadores y de los usuarios sobre la Justicia en Equidad en Armenia, Quindío, generando conocimiento riguroso y contextuado (contando con perspectivas y expresiones propias de los protagonistas) sobre el tema y proponiendo elementos de debate para la comprensión del mismo en Colombia, afirmando que parte de un sentido de lo justo socialmente configurado y continuamente reelaborado, a través de los discursos que convocan a sus diversos actores.
La maternidad subrogada en Colombia: hacia un marco jurídico integral e incluyente
Authors: Beetar Bechara Brajim
Published: July 2019

La maternidad subrogada es un tema que se está presentando en Colombia y que necesita regulación expresa. El único referente jurídico sobre la práctica de la maternidad subrogada en Colombia es la Sentencia T-968 de 2009 de la Corte Constitucional. En esta sentencia la Corte definió este procedimiento como: “El acto reproductor que genera el nacimiento de un niño gestado por una mujer sujeta a un pacto o compromiso mediante el cual debe ceder todos los derechos sobre el recién nacido a favor de otra mujer que figurará como madre de éste”. En Colombia, a pesar de la ventaja legislativa que tienen otros países del contexto latinoamericano, se presenta un rezago y apenas se está dando el trámite de un proyecto de ley, el cual inició como un intento de migrar al país hacia el marco de la prohibición absoluta pero que en la actualidad se está discutiendo implementar bajo la posibilidad del régimen de permisión regulada. El objetivo principal de este trabajo radica en proponer un marco de legislación sobre el tema de maternidad subrogada para Colombia.
La corrupción como delito en el pensamiento del siglo xix. Un esbozo de su conformación jurídico-penal en la historia desde la filosofía
Authors: Ruiz-Morales Manuel
Published: July 2019

El artículo estudia el proceso de conformación de la corrupción como conducta delictiva durante el siglo XIX por parte de los principales pensadores de dicho siglo. De este modo, se analizará desde un enfoque histórico-filosófico el significado penal que a partir de las revoluciones de finales del XVIII se le dio al fenómeno séptico.Igualmente, el trabajo atiende a los aspectos históricos, sociales, políticos y económicos del momento, ya que para comprender el sentido de las teorías filosóficas que vieron la luz en mencionada centuria, se tienen que tener en cuenta estos aspectos circunstanciales anejos.Finalmente, se podrá observar las soluciones planteadas durante mencionado siglo desde un plano filosófico, que serán primordialmente de corte utilitarista. Por tanto, probablemente aplicar las propuestas de lucha frente a la corrupción de los grandes pensadores de la Historia de la Humanidad podría ser una respuesta eficaz al fenómeno séptico, toda vez que las medidas utilizadas hogaño parecen caracterizarse por su escasa innovación, habiendo desarrollado los filósofos –desde la Antigüedad- propuestas más ambiciosas en el campo de la contención y de la eliminación de la corrupción.
Search and Learning at a Daily Deals Website
Authors: Hu Mantian (Mandy) , Dang Chu (Ivy) , Chintagunta Pradeep K.
Published: July 2019

We formulate a dynamic model of search and Dirichlet learning to explain consumer behavior at a daily deal website.
A BELEZA E A ARTE REVISTAS NA OBRA “RETRATO DE DORIAN GRAY”
Authors: Araújo Sarah Da Silva , Araújo Sandra Fátima Da Silva , Araújo Sabrina Da Silva
Published: July 2019

O Presente Texto busca mostrar a representação da beleza em “O Retrato de Dorian Gray”, obra que gira ao redor da questão estética e dos estereótipos associados. O culto à imagem é uma característica marcante do homem moderno regida por padrões mundialmente pré-estabelecidos para o que vem (ou não) a ser belo. Isto é, busca-se incessantemente o “corpo ideal” sob a perspectiva incondicional da beleza, da jovialidade, enfim, da aparência em si. Para realização do trabalho postula-se um suporte teórico de autores que versam sobre arte, literatura e cultura, realiza-se então uma abordagem qualitativa, adotando-se a metodologia da revisão bibliográfica e da análise de conteúdo por constituírem indicadores indispensáveis para uma compreensão da sociedade do século XIX (período em que a obra foi escrita e em que o enredo se desenvolve), também chamado de Era Vitoriana, um dos períodos áureos da Inglaterra, em que prevaleciam convenções moralistas e sociais.
UMA ANÁLISE DISCURSIVA DO PROCESSO DE CONSTRUÇÃO IDENTITÁRIA DE MARIA EMÍLIA NO CONTO “SENHOR DIRETOR”
Authors: Da Luz Giselle Aparecida , FULLAN DANIELLE CRISTINE
Published: July 2019

O presente estudo visa analisar o conto “Senhor Diretor”, de Lygia Fagundes Telles (2009[1977]), com o objetivo de verificar como se dá a construção identitária da protagonista Maria Emília. Para tanto, a fundamentação teórica de nossas discussões será respaldada em Charaudeau (2009), no que se refere à identidade social e a identidade discursiva; e em Hartog (1999 [1980]), em relação à retórica da alteridade. Com base em nossas análises, foi possível compreender que ao Maria Emília buscar descrever o que se passava ao seu redor acaba por narrar-se e apresentar seus valores e suas crenças para seus interlocutores.
Muito mais que diversão - contribuições de Maria Nikolajeva sobre literatura infanto-juvenil
Authors: Nikolajeva Maria , Araújo Everaldo Lima de , Felipe Márcia Da Gama Silva , Mendes Thales Sant'Ana Ferreira
Published: July 2019

Maria Nikolajeva nasceu na Rússia e se mudou para a Suécia em 1981. Mestre em Inglês pela Universidade Estadual de Moscou (Rússia) e doutora em Literatura Comparada pela Universidade de Estocolmo (Suécia) – onde trabalhou por 25 anos –, é Professora e Catedrática de Educação na Universidade de Cambridge (Reino Unido). Já foi presidente (1993-1997) da International Research Society for Children’s Lierature e uma das editoras seniores da Oxford Encyclopedia of Children's Literature. Em 2005, recebeu o International Brothers Grimm Award pela contribuição de seu trabalho sobre literatura infantil. É autora de mais de 300 artigos e de algumas dezenas de livros, incluindo From mythic to linear: time in children's literature (2000), Power, voice and subjectivity in literature for young readers (2010) e Reading for Learning: cognitive approaches to children's literature (2014). Sua obra mais conhecida no Brasil é Livro ilustrado: palavras e imagens (Cosac Naify, 2011), escrito em 2001, com a professora Carole Scott.Por e-mail, gentilmente a professora Maria Nikolajeva nos concedeu esta entrevista, carregada de posicionamentos sobre leitura e literatura infanto-juvenil. Com presteza, a professora ainda nos presenteou com a versão em inglês dessa conversa. É possível perceber importantes nuanças reflexivas para além da realidade brasileira, pondo em evidência o escopo dos estudos que tratam da literatura infantil e juvenil, seja no âmbito do ensino e da pesquisa.
ESCALA E TEMPO NA ANÁLISE DA PAISAGEM
Authors: Costa Evelyn De Castro Porto , Seabra Vinicius Da Silva
Published: July 2019

O conceito de escala é de suma importância para estudos geográficos de qualquer natureza, sendo importante compreender as definições desse conceito para realizar escolhas adequadas da escala em estudos geográficos. A escala espacial e a temporal são variáveis importantes na delimitação da área e estudos, sendo o fenômeno estudado responsável pela escolha mais apropriada das escalas. Também é relevante ressaltar que com o desenvolvimento das geotecnologias, a perspectiva escalar ganha destaque nas imagens de sensoriamento remoto, tendo em vista a correlação desse conceito com as generalizações cartográficas e detalhamento do objeto. Nesse sentido, este trabalho discute os conceitos de escala, apresentando sua importância para os estudos geográficos, dando ênfase na análise da paisagem em perspectivas espaço-temporais.  Para o estudo foram realizados levantamentos bibliográficos de autores que trabalham com o conceito de escala em diferentes perspectivas, utilizando exemplos do uso de escalas em estudos geográficos.
Dementia 2. Alzheimer's disease: diagnosis, treatment and managment
Authors: Nazarko Linda
Published: July 2019

In the UK, an estimated 954 000 people have dementia. Alzheimer's-type dementia (AD) is the most common type of dementia and affects around 591 480 people ( Prince et al, 2014 ). This article, the second in a series, explains about the pathophysiology and clinical features of AD, how it is diagnosed and the medication used to treat it.
Anti–Hu-Mediated Paraneoplastic Chronic Intestinal Pseudo-Obstruction Arising From Small Cell Prostate Cancer
Authors: Cerra-Franco Javier A. , Fernandez-Cruz Carlos , Estremera-Marcial Rodolfo , Pagan-Torres Hendrick , Martinez-Souss Jaime , Toro Doris H.
Published: July 2019

Chronic intestinal pseudo-obstruction is a rare syndrome with high morbidity and mortality. The pathophysiology is not well understood, although it is postulated that it involves some sort of neuropathic and/or myopathic dysfunction resulting in intestinal dysmotility. We present the first case of chronic intestinal pseudo-obstruction secondary to a paraneoplastic syndrome associated with a primary small cell prostate cancer.
The Suicide of Leelah Alcorn: Whiteness in the Cultural Wake of Dying Queers
Authors: Schares Evan Mitchell
Published: July 2019

In this article, I examine public discourse in the wake of transgender teenager Leelah Alcorn’s suicide. I argue that Alcorn’s politicized suicide beckoned a national tragedy whereas the slew of queer and transgender people of color murdered did not because of the repeated deployments of a whiteness-derived innocence. Performances of hegemonic grief evinced Alcorn’s posthumous rhetorical agency in ways that caused responsible adults to take action against the violence of conversion therapy on U.S. queer youth. In this article, I analyze how the rhetorics and performances of white grief functioned as an exigence for a queer of color critique that used the wake of Alcorn to unhinge logics of white supremacy and white grievability. As queers of color labored in Alcorn’s wake to grieve their own dead in more public ways, they demonstrated how queers of color shoulder the burden of evincing their own trauma more so than their white counterparts. The cultural wake of Alcorn suggests that hegemonic grief functions as a modality of white supremacy while determining whose life is worthy of remembrance and a place in the queer imaginary.
Numéro 149 - juillet 2019
Authors: Attanasi Gautier , Bodart Vincent , Courtoy François , Fontenay Sébastien , Ounnas Alexandre , Sauvenier Mathieu
Published: July 2019

Malgré de nombreuses créations d’emplois, un chômage au plus bas et une hausse significative du pouvoir d’achat, l’économie belge progresse toujours lentement. Sa croissance devrait rester faible sur l’ensemble de la période de projection. L’environnement international s’est en effet assombri, la croissance économique en zone euro ayant notamment fortement ralenti. L’expansion de l’économie belge devrait dès lors reposer avant tout sur la demande intérieure mais, en raison de la dégradation de la confiance des ménages et des entreprises, la progression de celle-ci serait considérablement freinée sur la période de projection. Dans ce contexte, la croissance de l’économie belge resterait limitée à 1,1 % en 2019 et 1,2 % en 2020.
State Feedback Controller Design of an Active Suspension System for Vehicles Using Pole Placement Technique
Authors: Wéber Andrea , Kuczmann Miklós
Published: July 2019

The paper presents a method for designing a state feedback controller of an active suspension system of a quarter car model. This is a survey based on a specific example. The designed controller of the active suspension system improves the driving control, safety and stability, because during the ride, the periodic swinging motion generated by the road irregularities on wheels can be decreased. This periodic motion damages the driving comfort, and may cause traffic accidents. The state feedback controller is designed to stand road induced displacements. Computer simulations of the designed controller have been performed in the frame of Scilab and XCos.
FNDC5/Irisin counteracts lipotoxic-induced apoptosis in hypoxic H9c2 cells
Authors: Moscoso Isabel , Cebro-Márquez María , Rodríguez-Mañero Moisés , González-Juanatey José Ramón , Lage Ricardo
Published: July 2019

Irisin is a newly identified adipokine critical to modulate body metabolism, fatty acid metabolism and oxidative stress; recent evidence suggests a cardioprotective role in ischemic injury. Loss of cardiomyocytes during acute myocardial infarction is strongly associated with energetic changes and lipotoxic-induced apoptosis. Our aim was to study FNDC5/irisin’s potential protective role against hypoxia and lipotoxicity, both related with myocardial infarction environment. H9c2 cells were treated with palmitate and/or irisin in normoxic/hypoxic conditions. Cell viability and apoptosis were assessed by MTT assay and annexin V/PI staining. Immunoblotting was used to confirm apoptotic cascade regulation. Irisin counteracts lipotoxic-induced apoptosis in hypoxic cardiomyoblasts by activating Akt signaling pathway suggesting the potential therapeutic role of irisin in ischemic heart disease.
Surgery for the Venous Disaster - Phlegmasia Cerulea Dolens
Authors: Lee Chien-Hui , Hsieh Yung-Kun
Published: July 2019

Phlegmasia cerulea dolens is an acute fulminating form of extensive venous thrombosis. Limb loss, post-thrombotic syndrome and life-threatening conditions can occur without appropriate management.
Treatment methods vary; there presently is no consensus on the best form of treatment. Endovascular procedures have been a good option for treating deep vein thrombosis, yet they may be insufficient for patients suffering from phlegmasia cerulea dolens. Venous thrombectomy with the guidance of venography quickly relieves symptoms, hardly causes complications, yields optimal mid-term results, and can be a justifiable treatment for phlegmasia cerulea dolens.
FOTOACÚSTICA PULSADA APLICADA A LA DETERMINACIÓN DE UMBRALES DE ABLACIÓN LÁSER EN METALES
Authors: Agreda-Paredes Jesús N. , Agreda-Delgado Jhenry F. , Aldama Reyna Claver W.
Published: July 2019

Se determinaron los umbrales de ablación láser de los metales cobre, oro y plata para la radiación láser de 1064 nm de un láser Nd:YAG de nanosegundos utilizándose la técnica fotoacústica pulsada para registrar las señales fotoacústicas producidas debido a la interacción del metal con los pulsos láser. Dichas señales se analizaron mediante correlación estándar y los cambios en la amplitud fotoacústica conforme aumento la fluencia láser. Los resultados indican que las señales fotoacústicas son muy sensibles a cambios físicos que experimenta una muestra solida debido a la interacción con pulsos láser, pudiendo diferenciarse claramente el cambio del régimen termoelástico al de ablación y por consiguiente el umbral de ablación. Los valores obtenidos para la fluencia umbral fueron: (1.71±0.08) J/cm2  para el cobre, (1.65±0.09) J/cm2 para el oro y (1.15±0.05) J/cm2 para la plata.
ANALISIS ATAS KEBIJAKAN PEMERINTAH TENTANG BPJS DAN JKN MELALUI UU 36 TAHUN 2009 TENTANG KESEHATAN
Authors: Sugyati Cucu
Published: July 2019

This study seeks to make a deep systematic analysis of the involvement of the community as an additional implementing element in the implementation of public health policy, especially in the field of mother and child in West Java, Indonesia. This descriptive-qualitative study presents a discussion of how the elements of public health practitioners interact with communities in West Java Province so that their knowledge and skills are needed. With the theory of health services, data obtained that (a) service and network cooperation in public health institutions, within the Provincial Government of West Java is quite uniform and well implemented; (b) in carrying out its obligations as the implementing element of the community deeply understand public policy in the field of public health, especially maternal and child health; so they can carry out their functions to serve the community. Nevertheless, the lack of community volunteers directly addressing maternal and child health is felt so that this review recommends incentives for health workers coming from ordinary people.
Sikap Warga Pesantren tentang Fenomena Radikalisme Agama
Authors: Adilan Dilan Imam
Published: July 2019

This study focuses on the views and attitudes of Pesantren residents about the religious radicalism-fundamentalism phenomena in two tahfiz (Qur’anic memorized) pesantrens in Bandung. This descriptive-analytical study employs data collection through interviews, document research, and observation. The result of the study is that about the relationship between views and attitudes, the two pesantren citizens carried a moderate paradigm. They tend to try to integrate views that are antagonistic in looking at Islamic relations and social issues. Also they wanted to soften the conservative paradigm that is the light of religious fundamentalism-views and attitudes, which often make a generalization that Islam has opinion that is inseparable from the modernization and progress of the times.
Ideal based trace graph of matrices
Authors: THİRUGNANAM Tamizh Chelvam , SİVAGAMİ M.
Published: July 2019

Let $R$ be a commutative ring and $M_n(R)$ be the set of all $n\times n$ matrices over $R$ where $n\geq 2.$ The trace graph of the matrix ring $M_n(R)$ with respect to an ideal $I$ of $R,$ denoted by $\Gamma_{I^t}(M_n(R)),$ is the simple undirected graph with vertex set $M_n(R)\setminus M_n(I)$ and two distinct vertices $A$ and $B$ are adjacent if and only if Tr$(AB) \in I.$ Here Tr$(A)$ represents the trace of the matrix $A.$ In this paper, we exhibit some properties and structure of $\Gamma_{I^t}(M_n(R)).$
On some subclasses $k$-uniformly Janowski starlike and convex functions associated with $t$-symmetric points
Authors: NOOR Khalida Inayat , KHAN Nasir , ARİF Muhammad , SOKOL Janusz
Published: July 2019

In this paper, we define new subclasses of $k$-uniformly Janowski starlike and $k$-uniformly Janowski convex functions associated with $t$-symmetric points. The integral representations, convolution properties and coefficient bounds for these classes are studied.
Kara Ahmed Paşa ve Vakıfları
Authors: BİCİK Mehmet
Published: July 2019

Muhteşem Süleyman’ın Veziriazamı Kara Ahmed Paşa ve Vakıfları" adlı kitap ise Mehmet Bicik tarafından tanıtıldı.
FLASH v2.0 v1
Authors: Lyden Amy , Castañeda Gloria , Crawford Emily , Caldera Saharai , Quan Jenai , Travisano Katherine
Published: July 2019

FLASH is a crispr-cas9 technology that enriches for targeted sequences in sequencing libraries. The initial DNA sample undergoes a blocking step that removes of the 5’ phosphoryl groups of the DNA fragments, resulting in a product that is not amendable for downstream adaptor ligation or amplification via standard Illumina-based library preparation. The subsequent incorporation of targeted CRISPR-cas9 library exposes the desired regions of interest, allowing them to be processed into a library. For more information on methods and results, please see the FLASH paper. For FLASH guide RNA design help, please see our github.
09 Expression v1
Authors: China Tjusls
Published: July 2019

Make the big batch of bacteria culture for protein expression.