bluuebunny/crossref_metadata_2025 huggingface dataset:
ROS Mediate xCT-Dependent Cell Death in Human Breast Cancer Cells under Glucose Deprivation
Authors: Chen Mei-Chun , Hsu Li-Lin , Wang Sheng-Fan , Hsu Chih-Yi , Lee Hsin-Chen , Tseng Ling-Ming
Published: July 2020

xCT, also known as solute carrier family 7 member 11 (SLC7A11), the light chain of the cystine/glutamate antiporter, is positively correlated with cancer progression due to antioxidant function. During glucose deprivation, the overexpression of xCT does not protect cancer cells but instead promotes cell death. Further understanding the mechanism of glucose deprivation-induced cell death is important for developing anticancer treatments targeting the glucose metabolism. In this study, we found that breast cancer cells with a high expression of xCT demonstrated increased levels of reactive oxygen species (ROS) and were more sensitive to glucose deprivation than the cells with a low expression of xCT. However, AMP-activated protein kinase (AMPK) did not significantly affect glucose-deprivation-induced cell death. The antioxidant N-acetyl-cysteine prevented glucose-deprivation-induced cell death, and the glutathione biosynthesis inhibitor L-buthionine-S, R-sulfoximine enhanced glucose-deprivation-induced cell death. The inhibition of xCT by sulfasalazine or a knockdown of xCT reduced the glucose-deprivation-increased ROS levels and glucose-deprivation-induced cell death. Glucose deprivation reduced the intracellular glutamate, and supplementation with α-ketoglutarate prevented the glucose-deprivation-increased ROS levels and rescued cell death. The knockdown of sirtuin-3 (SIRT3) further enhanced the ROS levels, and promoted xCT-related cell death after glucose deprivation. In conclusion, our results suggested that ROS play a critical role in xCT-dependent cell death in breast cancer cells under glucose deprivation.
Low Friction at the Nanoscale of Hydrogenated Fullerene-Like Carbon Films
Authors: Liu Zhao , Wang Yongfu , Glatzel Thilo , Hinaut Antoine , Zhang Junyan , Meyer Ernst
Published: July 2020

Friction force microscopy experiments at the nanometer scale are applied to study low friction of hydrogenated fullerene-like carbon films. The measured friction coefficients indicate that lower hydrogen concentration during preparation is beneficial to enter the low friction regime, especially in combination with only methane as precursor. Furthermore, two regions are found with distinct friction coefficients and surface roughnesses related to different surface structures. One is rich in amorphous carbon and the other is rich in fullerene-like carbon, dispersed on the same surface. Transmission electron microscopy and Raman spectroscopy images verify this observation of the two separated structures, especially with the extracted fullerene-like structures in the wear debris from macro friction experiments. It is speculated that hydrogen may tend to impair the growth of fullerene-like carbon and is therefore detrimental for lubricity.
What EBSD and TKD Tell Us about the Crystallography of the Martensitic B2-B19′ Transformation in NiTi Shape Memory Alloys
Authors: Cayron Cyril
Published: July 2020

The complex and intricate microstructure of B19′ martensite in shape memory nickel titanium alloys is generally explained with the Phenomenological Theory of Martensitic Crystallography (PTMC). Over the last decade, we have developed an alternative approach that supposes the existence of a “natural” parent–daughter orientation relationship (OR). As the previous TEM studies could not capture the global crystallographic characteristics of the B2→B19′ transformation required to discriminate the models, we used Electron BackScatter Diffraction (EBSD) and Transmission Kikuchi Diffraction (TKD) to investigate a polycrystalline NiTi alloy composed of B19′ martensite. The EBSD maps show the large martensite plates and reveal the coexistence of different ORs. The TKD maps permit us to image the “twins” and confirm the continuum of orientations suspected from EBSD. The results are interpreted with the alternative approach. The predominant OR in EBSD is the “natural” OR for which the dense directions and dense planes of B2 and B19′ phases are parallel—i.e., (010)B19′//(110)B2 and [101]B19′//[ 1 ¯ 11]B2. The natural OR was used to automatically reconstruct the prior parent B2 grains in the EBSD and TKD maps. From the distortion matrix associated with this OR, we calculated that the habit plane could be (1 1 ¯ 2)B2//(10 1 ¯ )B19′. The traces of these planes are in good agreement with the EBSD maps. We interpret the other ORs as “closing-gap” ORs derived from the natural OR to allow the compatibility between the distortion variants. Each of them restores a parent symmetry element between the variants that was lost by distortion but preserved by correspondence.
Photo-Aligned Ferroelectric Liquid Crystal Devices with Novel Electro-Optic Characteristics
Authors: Chigrinov Vladimir , Guo Qi , Kudreyko Aleksey
Published: July 2020

This paper examines different applications of ferroelectric liquid crystal devices based on photo-alignment. Successful application of the photo-alignment technique is considered to be a critical breakthrough. A variety of display and photonic devices with azo dye aligned ferroelectric liquid crystals is presented: smart glasses, liquid crystal Pancharatnam–Berry phase optical elements, 2D/3D switchable lenses, and laser therapy devices. Comparison of electro-optical behavior of ferroelectric liquid crystals is described considering the performance of devices. This paper facilitates the optimization of device design, and broadens the possible applications in the display and photonic area.
Novel Pb(II) Complexes: X-Ray Structures, Hirshfeld Surface Analysis and DFT Calculations
Authors: Mahmoudi Ghodrat , Kumar Seth Saikat , Bauza Riera Antonio , Ivanovich Zubkov Fedor , Frontera Antonio
Published: July 2020

Herein we report the synthesis and detailed structural characterization of two new centrosymmetric dinuclear coordination compounds of Pb(II) [Pb2L2(NCS)4] (1) and [Pb2L2(NO3)4]∙2MeOH (2), using the organic ligand 1,2-diphenyl-1,2-bis((methyl(pyridin-2-yl)methylene)hydrazono)ethane (L). In both complexes, each subunit [PbLX2 (X = NO3 or NCS)] adopts a quasi-aromatic Möbius metal chelate structure. Each ligand L is coordinated in a tetradentate coordination mode to Pb(II), yielding the 12π electron chelate ring via two pyridyl-imine units. In compound (1), the coordination sphere is completed by one disordered N,S-coordinated thiocyanate anion and two μ1,1-bridging N-coordinated thiocyanate anions. In compound (2), the coordination sphere of Pb(II) is completed by two monodentate and two bidentate nitrato ligands (two of them acting as bridging ligands). Crystal packing of both compounds is stabilized by intermolecular hydrogen bonds, intra- and intermolecular C–H∙∙∙π interactions. The Hirshfeld molecular surfaces of (1) and (2) demonstrate that their packing is dominated by C–H∙∙∙O/N/S interactions as well as by far less favored H∙∙∙H contacts.
Cocrystals of Isoniazid with Polyphenols: Mechanochemical Synthesis and Molecular Structure
Authors: González-González Juan Saulo , Martínez-Santiago Ana María Monserrat , Martínez-Martínez Francisco Javier , Emparán-Legaspi María José , Pineda-Contreras Armando , Flores-Alamo Marcos , García-Ortega Héctor
Published: July 2020

Isoniazid is used as anti-tuberculosis drug which possesses functional groups capable of forming hydrogen bonds. A series of cocrystals of isoniazid (INH) with polyphenolic coformers such as catechol (CAT), orcinol (ORC), 2-methylresorcinol (MER), pyrogallol (PYR), and phloroglucinol (PLG) were prepared by solvent-assisted grinding. Powder cocrystals were characterized by infrared (IR) spectroscopy and X-ray powder diffraction. The crystal structure of the cocrystals revealed the unexpected hydration of the INH-MER cocrystal and the preference of the (phenol) O–H∙∙∙N (pyridine) and (terminal) N-H∙∙∙O (phenol) heterosynthons in the stabilization of the structures. The supramolecular architecture of the cocrystals is affected by the conformation and the substitution pattern of the hydroxyl groups of the polyphenols.
Beyond the EU Structural Funds’ Absorption Rate: How Do Regions Really Perform?
Authors: Aivazidou Eirini , Cunico Giovanni , Mollona Edoardo
Published: July 2020

Although the EU structural funds aim to alleviate disparities through supporting regional development, their impact on local economies and societies is considered as uneven. As existing studies explore the absorption rate of the EU share of contribution as a point-in-time indicator at the end of the policy cycle, evidence about regional co-finance and the factors dynamically affecting absorption performance is lacking. To that end, this paper aims to provide a new longitudinal investigation of the absorption time series and develop an original indicator, supported by a statistical error analysis, for offering a transparent view of the total funds’ absorption. The analysis highlights that undesired regional strategies due to low administrative capacity may increase the absorption rate, though without supporting regional growth. The proposed approach could further facilitate the equitable allocation of political accountability regarding the structural funds’ absorption to the EU and the regions. Overall, it is anticipated that this research will support the EU in monitoring actual regional performance for prompting local managing authorities to improve their administrative capacity.
Passive Optical Networks Progress: A Tutorial
Authors: Horvath Tomas , Munster Petr , Oujezsky Vaclav , Bao Ning-Hai
Published: July 2020

For many years, passive optical networks (PONs) have received a considerable amount of attraction regarding their potential for providing broadband connectivity to almost every citizen, especially in remote areas where fiber optics can attract people to populate regions that have been abandoned. Error-free connectivity without dropouts can offer new opportunities to communicate, earn money and enjoy cultural events. Transmission speeds are multigigabit with distances of a few tens of kilometers; these specifications were previously reserved for high-speed and long-haul backbone networks. PONs can also support a new class of applications, such as accurate time transfer or distributed fiber sensing and follow new trends in open networking. An outline of past and current standards and standards that have been proposed for the latest generation of multigigabit PONs is provided.
Potential Applications of Biogas Produced in Small-Scale UASB-Based Sewage Treatment Plants in Brazil
Authors: Passos Fabiana , Bressani-Ribeiro Thiago , Rezende Sonaly , Chernicharo Carlos A. L.
Published: July 2020

Rural sanitation is still a challenge in developing countries, such as Brazil, where the majority population live with inadequate services, compromising public health and environmental safety. In this context, this study analyzed the demographic density of these rural agglomerations using secondary data from the Brazilian Institute of Geography and Statistics (IBGE). The goal was to identify the possibilities associated with using small-scale upflow anaerobic sludge blanket (UASB) reactors for sewage treatment, mainly focusing on biogas production and its conversion into energy for cooking, water heating and sludge sanitization. Results showed that most rural agglomerations lacking the appropriate sewage treatment were predominant from 500 to 1500 inhabitants in both northern and southern Brazilian regions. The thermal energy available in the biogas would be enough to sanitize the whole amount of sludge produced in the sewage treatment plants (STPs), producing biosolids for agricultural purposes. Furthermore, the surplus of thermal energy (after sludge sanitization) could be routed for cooking (replacing LPG) and for water heating (replacing electricity) in the northern and southern regions, respectively. This would benefit more than 200,000 families throughout rural areas of the country. Besides the direct social gains derived from the practice of supplying biogas for domestic uses in the vicinity of the STPs, there would be tremendous indirect gains related to the avoidance of greenhouse gas (GHG) emissions. Therefore, an anaerobic-based sewage treatment may improve public health conditions, life quality and generate added value products in Brazilian rural areas.
Large-Eddy Simulation of ECN Spray A: Sensitivity Study on Modeling Assumptions
Authors: Gadalla Mahmoud , Kannan Jeevananthan , Tekgül Bulut , Karimkashi Shervin , Kaario Ossi , Vuorinen Ville
Published: July 2020

In this study, various mixing and evaporation modeling assumptions typically considered for large-eddy simulation (LES) of the well-established Engine Combustion Network (ECN) Spray A are explored. A coupling between LES and Lagrangian particle tracking (LPT) is employed to simulate liquid n-dodecane spray injection into hot inert gaseous environment, wherein Lagrangian droplets are introduced from a small cylindrical injection volume while larger length scales within the nozzle diameter are resolved. This LES/LPT approach involves various modeling assumptions concerning the unresolved near-nozzle region, droplet breakup, and LES subgrid scales (SGS) in which their impact on common spray metrics is usually left unexplored despite frequent utilization. Here, multi-parametric analysis is performed on the effects of (i) cylindrical injection volume dimensions, (ii) secondary breakup model, particularly Kelvin–Helmholtz Rayleigh–Taylor (KHRT) against a no-breakup model approach, and (iii) LES SGS models, particularly Smagorinsky and one-equation models against implicit LES. The analysis indicates the following findings: (i) global spray characteristics are sensitive to radial dimension of the cylindrical injection volume, (ii) the no-breakup model approach performs equally well, in terms of spray penetration and mixture formation, compared with KHRT, and (iii) the no-breakup model is generally insensitive to the chosen SGS model for the utilized grid resolution.
Applied Research of the Hygrothermal Behaviour of an Internally Insulated Historic Wall without Vapour Barrier: In Situ Measurements and Dynamic Simulations
Authors: Andreotti Mirco , Bottino-Leone Dario , Calzolari Marta , Davoli Pietromaria , Dias Pereira Luisa , Lucchi Elena , Troi Alexandra
Published: July 2020

The hygrothermal behaviour of an internally insulated historic wall is still hard to predict, mainly because the physical characteristics of the materials composing the historic wall are unknown. In this study, the hygrothermal assessment of an internally thermal insulated masonry wall of an historic palace located in Ferrara, in Italy, is shown. In situ non-destructive monitoring method is combined with a hygrothermal simulation tool, aiming to better analyse and discuss future refurbishment scenarios. In this context, the original U-value of the wall (not refurbished) is decreased from 1.44 W/m2K to 0.26 W/m2K (10 cm stone wool). Under the site specific conditions of this wall, not reached by the sun or rain, it was verified that even in the absence of vapour barrier, no frost damage is likely to occur and the condensation risk is very limited. Authors proposed further discussion based on simulation. The results showed that the introduction of a second gypsum board to the studied technology compensated such absence, while the reduction of the insulation material thickness provides a reduction of RH peaks in the interstitial area by 1%; this second solution proved to be more efficient, providing a 3% RH reduction and the avoidance of further thermal losses.
Extended Flow-Based Security Assessment for Real-Sized Transmission Network Planning
Authors: Dicorato Maria , Trovato Michele , Vergine Chiara , Gadaleta Corrado , Aluisio Benedetto , Forte Giuseppe
Published: July 2020

The evolution of electric power systems involves several aspects, dealing with policy and economics as well as security issues. Moreover, due to the high variability of operating conditions, evolution scenarios have to be carefully defined. The aim of this paper is to propose a flow-based procedure for the preliminary security analysis of yearly network evolution scenarios at the real scale level. This procedure is based on hourly load and generation conditions given by market solutions, and exploits Power Transfer Distribution Factors and Line Outage Distribution Factors to determine N and N−1 conditions, properly accounting for possible islanding in the latter case. The analysis of overloads is carried out by dealing with big data analysis through statistic indicators, based on power system background, to draw out critical operating conditions and outages. The procedure is applied to a provisional model of a European high voltage network.
Distributed Switched Optimal Control of an Electric Vehicle
Authors: Meyer Richard T.
Published: July 2020

Distributed control is investigated to solve an electric vehicle switched optimal control problem faster than centralized control without significant performance change. The powertrain includes a cooling system, supercapacitor, and two switched mode components: a battery with discharging and charging modes and an electric drive with motoring and generating modes. Control-oriented component power flow models are developed with mode and temperature dependence. Component specific power and thermal management optimization problems, subject to these models, require solution for overall powertrain management. The power management problem is switched, having discrete-valued mode selection variables. Both problems are solved in a distributed manner using the alternating direction method of multipliers (ADMM). An ADMM-based algorithm to solve the switched powertrain management problem is proposed; it (i) solves the embedded version of the switched problem that relaxes discrete mode switch values to continuous values and (ii) projects embedded mode selection values onto discrete values and then solves the problem with now known mode selections. The distributed solution approach is demonstrated using a trapezoidal drive profile and three regulatory profiles. The regulatory results are compared to centralized control and the proposed algorithm achieved at least a 3.3 times improvement in solution time with comparable drive performance.
Benchmarking of Modular Multilevel Converter Topologies for ES-STATCOM Realization
Authors: Chaudhary Sanjay K. , Cupertino Allan F. , Teodorescu Remus , Svensson Jan R.
Published: July 2020

In recent years, the integration of the high-power static synchronous compensator (STATCOM) and energy storage in the same device has gained interest. Such a system is referred to as ES-STATCOM. Modular multilevel converter (MMC) topologies constitute a promising converter family for ES-STATCOM realization, providing a modular and scalable solution with a high efficiency that handles high-power and high-voltage ratings in grid applications. There is a gap in technical literature discussing the design and the comparison of MMC-based ES-STATCOMs while utilizing batteries to find the most suitable MMC topology for ES-STATCOMs. Therefore, this paper benchmarks MMC family members for ES-STATCOM realization. Both centralized and distributed energy storage approaches are investigated. The proposed design flowcharts can be employed for comparison and optimization purposes. In total, seven topologies are compared in terms of number of cells, required silicon area and total battery volume. Different semiconductor devices and battery types are analyzed. The result indicates that centralized energy storage systems are the most suitable due to their design flexibility, low volume and small silicon area. Moreover, the possibility of using over-modulation in MMC using bridge cells has an important role in the optimization of ES-STATCOM. The results for the adopted case study shows that the decentralized approach can lead to 55% higher silicon area and 30% higher volume than the centralized approach. The double-star bridge cell MMC with centralized energy storage is determined as the most suitable solution for ES-STATCOM systems.
A GIS Approach to Locate a Small Size Biomass Plant Powered by Olive Pruning and to Estimate Supply Chain Costs
Authors: Latterini Francesco , Stefanoni Walter , Suardi Alessandro , Alfano Vincenzo , Bergonzoli Simone , Palmieri Nadia , Pari Luigi
Published: July 2020

The valorization of agricultural residues plays a fundamental role in renewable energy production. Particularly, the management of olive orchards in Lazio region generates a considerable amount of biomass that is currently unexploited, but it could represent a valid source of solid biofuel for energy production in the Lazio region (Italy). Using a Geographic Information System (GIS) approach entirely based on open source software, five suitable areas (A, B, C, D and E) have been selected as eligible for hosting and feeding a 1 MWe power plant. Harvesting and transportation costs were also calculated. The harvesting operation costs were EUR 96.79 Mgfm−1 in A, while they ranged from EUR 49.83 Mgfm−1 (E) up to EUR 56.51 Mgfm−1 (D) for the other sub-areas. Sub-area A showed also higher transport costs, EUR 21.55 Mgfm−1 while the same value ranged from EUR 14.75 Mgfm−1 (E) to EUR 16.59 Mgfm−1 (B) in the other sub-areas. However harvesting costs resulted higher than those reported in the literature, mainly due to the low pruning yield per surface unit, an aspect which is directly related to the olive grove’s management in the region where annual pruning is the usual practice. Future developments of the present study should encompass the social and environmental aspects of residual biomass supply chains herein proposed.
Effect of Candida intermedia LAMAP1790 Antimicrobial Peptides against Wine-Spoilage Yeasts Brettanomyces bruxellensis and Pichia guilliermondii
Authors: Peña Rubén , Vílches Jeniffer , G.-Poblete Camila , Ganga María Angélica
Published: July 2020

Wine spoilage yeasts are one of the main issues in the winemaking industry, and the control of the Brettanomyces and Pichia genus is an important goal to reduce economic loses from undesired aromatic profiles. Previous studies have demonstrated that Candida intermedia LAMAP1790 produces antimicrobial peptides of molecular mass under 10 kDa with fungicide activity against Brettanomyces bruxellensis, without affecting the yeast Saccharomyces cerevisiae. So far, it has not been determined whether these peptides show biocontroller effect in this yeast or other spoilage yeasts, such as Pichia guilliermondii. In this work, we determined that the exposure of B. bruxellensis to the low-mass peptides contained in the culture supernatant of C. intermedia LAMAP1790 produces a continuous rise of reactive oxygen species (ROS) in this yeast, without presenting a significant effect on membrane damage. These observations can give an approach to the antifungal mechanism. In addition, we described a fungicide activity of these peptides fraction against two strains of P. guilliermondii in a laboratory medium. However, carrying out assays on synthetic must, peptides must show an effect on the growth of B. bruxellensis. Moreover, these results can be considered as a start to develop new strategies for the biocontrol of spoilage yeast.
Interaction of Monocyte-Derived Dendritic Cells with Ara h 2 from Raw and Roasted Peanuts
Authors: Novak Natalija , Maleki Soheila J. , Cuadrado Carmen , Crespo Jesus F. , Cabanillas Beatriz
Published: July 2020

Ara h 2 is a relevant peanut allergen linked to severe allergic reactions. The interaction of Ara h 2 with components of the sensitization phase of food allergy (e.g., dendritic cells) has not been investigated, and could be key to understanding the allergenic potential of this allergen. In this study, we aimed to analyze such interactions and the possible mechanism involved. Ara h 2 was purified from two forms of peanut, raw and roasted, and labeled with a fluorescent dye. Human monocyte-derived dendritic cells (MDDCs) were obtained, and experiments of Ara h 2 internalization by MDDCs were carried out. The role of the mannose receptor in the internalization of Ara h 2 from raw and roasted peanuts was also investigated. Results showed that Ara h 2 internalization by MDDCs was both time and dose dependent. Mannose receptors in MDDCs had a greater implication in the internalization of Ara h 2 from roasted peanuts. However, this receptor was also important in the internalization of Ara h 2 from raw peanuts, as opposed to other allergens such as raw Ara h 3.
“For Me, They Were the Good Old Days”: Retrospective Narratives of Childhood Experiences in ‘the Gang’
Authors: Maitra Dev Rup
Published: July 2020

Much of the existing scholarship on gang membership predominantly focuses on adolescence as being the formative time period for the development of gang identities; however, there has thus far been more limited attention towards the childhood experiences of gang members, (i.e., pre-adolescence). The organising principle of this paper is to articulate the retrospective accounts of gang members’ childhoods, and how these recollections form a central role to the emergence of gang identities. The data presented in this paper were collected during fieldwork in two adult, men’s prisons in England; interviews were conducted with 60 active and former prison gang members, identified through prison databases; a small number (n = 9) of interviews were conducted with ‘street’ participants, such as ex-offenders, outreach workers and gang researchers. This paper aims to show that many gang members romanticise accounts of their childhoods, in spite of often having experienced adverse childhood experiences:, so too do many gang members view their childhood experiences as part of their mythologised narrative of life in ‘the gang’. Nevertheless, a tension exists between how gang members seek to portray their childhood experiences around gangs and the negative labelling and strain they experienced during their childhood; often, romanticised accounts seek to retrospectively neutralise these harms. In so doing, the lens through which childhood gang membership is viewed is one which conceptualises childhood gang involvement as being something non-deleterious, thus acting as a lens that attempts to neutralise the harms and vicissitudes of gang affiliation.
An Evaluation of Graphical Formats for the Summary of Activities of Daily Living (ADLs)
Authors: Byrne Caroline A. , O’Grady Michael , Collier Rem , O’Hare Gregory M. P.
Published: July 2020

Activities of Daily Living systems (ADLs) and the User Interface (UI) design principles used to implement them empowers the elderly to continue living a normal daily routine. The daily monitoring of activities for most Assisted Living (AL) systems demands/necessitates accurate daily user interaction, and the design principles for these systems often focus on the UI usability for the elder, not the caregiver/family member. This paper reviews Ambient Assisted Living (AAL) and ADLs UI designs and evaluates the usability of ADLs visualisation tools for caregivers. Results indicate that the UI presenting information in a bar graph format was the preferred option for respondents, as 60% chose this summarisation method over the alternative line graph UI, which had 38% of respondents selecting this format for information representation. Therefore, when designing Ambient Assisted Living (AAL) UIs, it is recommended that short periods of time are best presented in a pie graph format in combination with a bar graph format for representing extended timeline information to caregivers about their loved ones.
Subclinical Atherosclerosis Markers of Carotid Intima-Media Thickness, Carotid Plaques, Carotid Stenosis, and Mortality in Community-Dwelling Adults
Authors: Yang Chuan-Wei , Guo Yuh-Cherng , Li Chia-Ing , Liu Chiu-Shong , Lin Chih-Hsueh , Liu Chung-Hsiang , Wang Mu-Cyun , Yang Shing-Yu , Li Tsai-Chung , Lin Cheng-Chieh
Published: July 2020

Carotid intima–media thickness (IMT), plaque, and stenosis are widely used as early surrogate markers of subclinical atherosclerosis and strong predictors of future deaths and cardiovascular events. Albuminuria is an indicator of generalized endothelial dysfunction that speeds up atherosclerosis. However, previous studies reporting these associations cannot rule out the confounding effect of albuminuria. We aimed to examine the independent and joint relationships between IMT markers and 10-year mortality in community-dwelling Taiwanese adults. This work was a community-based prospective cohort study consisting of 2956 adults aged at least 30 years recruited in 2007 and followed up through 2019. Cox proportional hazard regression models were used to examine associations of these subclinical atherosclerosis markers with mortality. During an average of 9.41 years of follow up, 242 deaths occurred. The mortality rate was 8.70 per 1000 person-years. Compared with those with carotid IMT less than 1.0 mm, persons with severely increased carotid IMT (≥2.0 mm) had an increased risk for death (hazard ratio (HR): 1.79; 95% confidence interval (CI): 1.07, 3.00). Compared with those without carotid plaque, persons with carotid plaque were more likely to have an increased risk for death (1.65; 1.21–2.32). Compared with those with carotid stenosis less than 25%, persons with carotid stenosis of 25–36% had a significant increased risk for death (1.57; 1.12–2.22). Considering these three IMT markers along with the traditional risk factors (c-statistic: 0.85) significantly increased their predictive ability of mortality compared with any individual variable’s predictive ability (all p-values < 0.001 for comparisons of c-statistic values). Carotid IMT measures, including IMT thickness, carotid plaque, and carotid stenosis were significant independent predictors of mortality. Our study supports evidence of blood pressure-related media thickening markers to assess future mortality risks in Chinese adults of general population.
Sexual Harassment Experiences, Knowledge, and Coping Behaviors of Nursing Students in Taiwan During Clinical Practicum
Authors: Chang Ting-Shan , Tzeng Ya-Ling , Teng Yu-Kuei
Published: July 2020

Sexual harassment not only endangers nursing students’ physical and mental health but also considerably affects their future willingness to engage in the field of nursing. To identify experiences, knowledge, coping behaviors, and determinants of sexual harassment among nursing students during clinical practicum, this study conducted a cross-sectional survey where a structured self-report questionnaire was used. A total of 291 senior nursing students were recruited from four universities in Central Taiwan. Sixty-six nursing students (22.7%), including 59 women (23.3%) and 7 men (18.4%), reported experiencing sexual harassment during clinical practicum. Male students scored significantly higher than female students did on knowledge of sexual harassment (p = 0.028). Female students scored significantly higher than male students did on attitudes toward preventing and coping with sexual harassment (p = 0.05). Nursing students who were older, had fathers who had higher education levels, or had undergone gender-related courses were more likely to experience sexual harassment. More than one-fifth of nursing students experienced sexual harassment during their clinical practicum, making this a formidable challenge in nursing education. Education is required to prevent sexual harassment and enhance gender sensitivity among nursing students, who are at a greater risk of experiencing sexual harassment in clinical practicum.
The Matthew Effect in Recovery from Smartphone Addiction in a 6-Month Longitudinal Study of Children and Adolescents
Authors: Lee Seung-Yup , Lee Hae Kook , Choi Jung-Seok , Bang Soo-young , Park Min-Hyeon , Jung Kyu-In , Kweon Yong-Sil
Published: July 2020

The clinical course of problematic smartphone use (PSU) remains largely unknown due to a lack of longitudinal studies. We recruited 193 subjects with smartphone addiction problems for the present study. After providing informed consent, the subjects completed surveys and underwent comprehensive interviews regarding smartphone usage. A total of 56 subjects among the 193 initially recruited subjects were followed up for six months. We compared baseline characteristics between persistent addicted users and recovered users at the end of the 6-month follow-up. Persistent problematic smartphone users displayed higher baseline smartphone addiction severity and were more prone to develop mental health problems at the follow-up. However, baseline depressive or anxiety status did not significantly influence the course of PSU. PSU behaved more like an addictive disorder rather than a secondary psychiatric disorder. Harm avoidance, impulsivity, higher Internet use, and less conversation time with mothers were identified as poor prognostic factors in PSU. Lower quality of life, low perceived happiness, and goal instability also contributed to persistent PSU, while recovery increased these scores as well as measures of self-esteem. These findings suggest that the Matthew effect is found in the recovery of PSU with better premorbid psychosocial adjustment leading to a more successful recovery. Greater clinical resources are required for interventions in vulnerable populations to modify the course of this increasingly prevalent problematic behavior worldwide.
Harm Perceptions of the JUUL E-Cigarette in a Sample of Ever Users
Authors: Stevens Elise M. , Hébert Emily T. , Tackett Alayna P. , Leavens Eleanor L. S. , Wagener Theodore L.
Published: July 2020

Background: Monitoring trends and perceptions of new nicotine salt-based electronic cigarettes (ECs), like JUUL, is important to identify associations with product experimentation and use. Understanding harm perceptions of these new devices will inform prevention and intervention efforts. The current study assesses perceptions of the absolute harmfulness of JUUL use in addition to comparing it to other tobacco products. Methods: Participants (N = 839, 52% male) reporting ever use of JUUL were recruited from Amazon’s Mechanical Turk from January to March 2018. Respondents completed questionnaire items assessing demographics, co-use of non-JUUL products, JUUL use status (i.e., daily users (10.8%), non-daily users (29.4%), and triers (59.9%)), and JUUL and other tobacco products absolute harm perceptions. Results: Overall, participants rated JUUL as significantly less harmful than all other tobacco products (p < 0.001), except other ECs. Daily JUUL users rated JUUL as less harmful compared to non-daily JUUL users and JUUL triers (p < 0.05). JUUL was rated as more harmful by women compared to men (p < 0.05). Conclusions: Increased frequency of JUUL use was associated with decreased harm perceptions. JUUL was associated with reduced perceptions of absolute harm compared to most other tobacco products, except other ECs. Public health practitioners should develop public health interventions that increase harm perceptions of ECs.
A “Population Dynamics” Perspective on the Delayed Life-History Effects of Environmental Contaminations: An Illustration with a Preliminary Study of Cadmium Transgenerational Effects over Three Generations in the Crustacean Gammarus
Authors: Cribiu Pauline , Devaux Alain , Garnero Laura , Abbaci Khédidja , Bastide Thérèse , Delorme Nicolas , Quéau Hervé , Degli Esposti Davide , Ravanat Jean-Luc , Geffard Olivier , Bony Sylvie , Chaumot Arnaud
Published: July 2020

We explore the delayed consequences of parental exposure to environmentally relevant cadmium concentrations on the life-history traits throughout generations of the freshwater crustacean Gammarus fossarum. We report the preliminary results obtained during a challenging one-year laboratory experiment in this environmental species and propose the use of population modeling to interpret the changes in offspring life-history traits regarding their potential demographic impacts. The main outcome of this first long-term transgenerational assay is that the exposure of spawners during a single gametogenesis cycle (3 weeks) could result in severe cascading effects on the life-history traits along three unexposed offspring generations (one year). Indeed, we observed a decrease in F1 reproductive success, an early onset of F2 offspring puberty with reduced investment in egg yolk reserves, and finally a decrease in the growth rate of F3 juveniles. However, the analysis of these major transgenerational effects by means of a Lefkovitch matrix population model revealed only weak demographic impacts. Population compensatory processes mitigating the demographic consequences of parental exposure seem to drive the modification of life-history traits in offspring generations. This exploratory study sheds light on the role of population mechanisms involved in the demographic regulation of the delayed effects of environmental toxicity in wild populations.
Improving Safety of Transportation of Dangerous Goods by Railway Transport
Authors: Batarlienė Nijolė
Published: July 2020

The transport of dangerous goods by rail carries a high risk of accident and every effort should be made to ensure that such transport is carried out under the best possible safety conditions. The research objective was to analyze and identify the main risks associated with the transport of dangerous goods by rail as well as to identify and assess the main factors of safe transport in order to reduce the risk of accident. For this purpose, analysis of the literature, systematization, generalization, and evaluation by experts was applied. The article states that in order to ensure the safe transport of dangerous goods by rail, it is necessary to comply with the rules for loading and unloading dangerous goods, the established requirements and instructions, and technical conditions of wagons and their labelling as well as preventive measures to reduce the risk. Recommendations are provided on how to reduce accidents and incidents in the transport of dangerous goods by rail.
Detection of Material Extrusion In-Process Failures via Deep Learning
Authors: Zhang Zhicheng , Fidan Ismail , Allen Michael
Published: July 2020

Additive manufacturing (AM) is evolving rapidly and this trend is creating a number of growth opportunities for several industries. Recent studies on AM have focused mainly on developing new machines and materials, with only a limited number of studies on the troubleshooting, maintenance, and problem-solving aspects of AM processes. Deep learning (DL) is an emerging machine learning (ML) type that has widely been used in several research studies. This research team believes that applying DL can help make AM processes smoother and make AM-printed objects more accurate. In this research, a new DL application is developed and implemented to minimize the material consumption of a failed print. The material used in this research is polylactic acid (PLA) and the DL method is the convolutional neural network (CNN). This study reports the nature of this newly developed DL application and the relationships between various algorithm parameters and the accuracy of the algorithm.
Baseline Cognitive Performance Moderates the Effects of Physical Activity on Executive Functions in Children
Authors: Ishihara Toru , Drollette Eric S. , Ludyga Sebastian , Hillman Charles H. , Kamijo Keita
Published: July 2020

Findings regarding the effects of regular physical activity on cognition in children have been inconsistent due to a number of demographic factors and experimental considerations. The present study was designed to examine baseline cognitive performance and executive function demands, as possible factors underlying the lack of consensus in the literature, by investigating the moderating role of those factors on the effects of physical activity on cognition. We reanalyzed data from three randomized controlled trials, in which the effects of regular physical activity intervention on cognition were examined using executive function tasks that included at least two task conditions requiring variable executive function demands, with a cumulative total of 292 participants (9–13 years). The results indicate that cognitive improvements resulting from physical activity intervention were greater in children with lower baseline cognitive performance. The main analysis revealed that beneficial effects of physical activity intervention on cognitive performance were generally observed across executive function conditions. However, secondary analyses indicated that these general effects were moderated by baseline performance, with disproportionately greater effects for task conditions with higher executive function demands. These findings suggest that baseline cognitive performance is an individual difference variable that moderates the beneficial effects of physical activity on executive functions.
Pain Catastrophizing in Older Adults with Chronic Pain: The Mediator Effect of Mood Using a Path Analysis Approach
Authors: Dong Huan-Ji , Gerdle Björn , Bernfort Lars , Levin Lars-Åke , Dragioti Elena
Published: July 2020

Cognitive models of pain propose that catastrophic thinking is negatively associated with chronic pain. However, pain catastrophizing is a complex phenomenon requiring a multivariate examination. This study estimates the effects of mood variables (anxiety and depression) on pain catastrophizing in older adults with chronic pain. A postal survey addressing pain aspects was sent to 6611 people ≥ 65 years old living in south-eastern Sweden. Pain catastrophizing was measured using the pain catastrophizing scale. Anxiety and depression were assessed using two subscales of the general well-being schedule. Data were analysed using a path analysis approach. A total of 2790 respondents (76.2 ± 7.4 years old) reported chronic pain (≥three months). The mediation model accounted for 16.3% of anxiety, 17.1% of depression, and 30.9% of pain catastrophizing variances. Pain intensity, insomnia, number of comorbidities, and lifestyle factors (smoking, alcohol consumption, and weight) significantly affected both pain catastrophizing and mood. Anxiety (standardized path coefficient (bstd) = 0.324, p < 0.001) in comparison to depression (bstd = 0.125, p < 0.001) had a greater effect on pain catastrophizing. Mood mediated the relationship between pain catastrophizing and pain-related factors accounting for lifestyle and sociodemographic factors.
The Association between High Body Mass Index and Early Clinical Outcomes in Patients with Proximal Femur Fractures
Authors: Müller Michael , Gutwerk Alexander , Greve Frederik , Völker Lisa , Zyskowski Michael , Kirchhoff Chlodwig , Biberthaler Peter , Pförringer Dominik , Braun Karl
Published: July 2020

Background: Fractures of the proximal femur constitute daily work in orthopedic trauma surgery. With the continuous increase of obesity in the general population, surgeons face several known technical challenges. The aim of this study was to investigate the association of high body mass index (BMI) in patients with proximal femur fractures with intra- and postoperative adverse events, as well as with functional outcomes after successful surgery. Methods: In this retrospective, single-center cohort study, 950 patients who sustained a fracture of the proximal femur (femoral neck fracture or trochanteric fracture) and underwent surgical treatment at our level I trauma center between 2003 and 2015 were included. Patient-specific data were obtained in regard to demographics, comorbidities, and fracture morphology. In-hospital postoperative complications (i.e., need for revision surgery, wound site infection, pneumonia, urinary tract infection, necessary transfusion, and deep-vein thrombosis) were analyzed, along with the length of hospitalization and overall mortality rate. Functional outcome was assessed using the Barthel index and the patient’s ability to walk on crutches. Mortality rate and need for revision surgery were assessed over a two-year time period. Any adverse event was correlated to one of the four WHO’s BMI groups. Results: The cohort included 80 (8.4%) underweight patients, 570 (60.0%) normal weight patients, 241 (25.4%) overweight patients, and 59 (6.2%) obese patients. We found more femoral neck fractures (506, or 53%) than trochanteric fractures (444, or 47%). In bivariate analysis, no significant difference was found in regard to overall mortality or postoperative complications. Hospitalization time (LOS) differed between the underweight (12.3 ± 4.8 days), normal (13.6 ± 7.8 days), overweight (14.2 ± 11.7 days), and obese patients (16.0 ± 9.7 days) (p = 0.040). Operation time increased stepwise with increasing BMI: underweight = 85.3 ± 42.9 min; normal weight = 90.2 ± 38.2 min; overweight = 99.9 ± 39.9 min; obese = 117.2 ± 61.5 min (p < 0.001). No significant difference was found by analyzing functional outcomes. However, patients with intermediate BMI levels (18.5–30 kg/m2) tended to achieve the best results, as represented by a higher Barthel index score and the patient’s ability to walk on crutches. Conclusion: Increased BMI in patients with proximal femur fractures is associated with both longer operation time and length of hospitalization (LOS). Postoperative mobilization and functional outcomes appear to follow a reversed J-curve distribution (with overweight patients showing the best functional results), whereas both obese and underweight patients have associated poorer function.
Multi-Focus Image Fusion: Algorithms, Evaluation, and a Library
Authors: Zafar Rabia , Farid Muhammad Shahid , Khan Muhammad Hassan
Published: July 2020

Image fusion is a process that integrates similar types of images collected from heterogeneous sources into one image in which the information is more definite and certain. Hence, the resultant image is anticipated as more explanatory and enlightening both for human and machine perception. Different image combination methods have been presented to consolidate significant data from a collection of images into one image. As a result of its applications and advantages in variety of fields such as remote sensing, surveillance, and medical imaging, it is significant to comprehend image fusion algorithms and have a comparative study on them. This paper presents a review of the present state-of-the-art and well-known image fusion techniques. The performance of each algorithm is assessed qualitatively and quantitatively on two benchmark multi-focus image datasets. We also produce a multi-focus image fusion dataset by collecting the widely used test images in different studies. The quantitative evaluation of fusion results is performed using a set of image fusion quality assessment metrics. The performance is also evaluated using different statistical measures. Another contribution of this paper is the proposal of a multi-focus image fusion library, to the best of our knowledge, no such library exists so far. The library provides implementation of numerous state-of-the-art image fusion algorithms and is made available publicly at project website.