bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Psychedelics in Clinical Practice: Comparing Therapeutic Uses and Potential Harms
Authors: Tariq Rabeet
Published: March 2022

Psychedelics might be the oldest psychoactive agents known to be used for inducing religious or mystical experiences. Their strong psychoactive effect was discovered accidentally in 1943 after the synthesis of Lysergic acid diethylamide (LSD) in 1937. These drugs became a mainstream area of research following the synthesis of LSD; however, several political and social factors led to their ban in 1966, after which research on psychedelics remained limited. These drugs became a major topic of scientific and ethical debate in the 1990’s and the recent times have seen a ‘Psychedelic renaissance’ where the therapeutic value of psychedelics is being reconsidered. This article reports the historical perspective of psychedelics, pharmacologic action by 5-HT2A receptor agonism, and psychological effects and compares the proposed therapeutic uses, including uses in depression, PTSD, anxiety- related disorders, drug and alcohol addiction, neurodegenerative diseases, and auto-immune diseases to potential harms including the development of tolerance, hallucinogen persisting perception disorder, and potential psychosis. An analysis of history, pharmacology, and comparison of benefits and harms lead to the conclusion that the potential therapeutic benefits significantly outweigh the potential harms; thus, further research and clinical trials need to be conducted across different countries and cultures for their legal approval in clinical use.
Traditional villages empowerment in local wisdom preservation towards cultural tourism development
Authors: Suardana I Wayan , Gelgel I Putu , Watra I Wayan
Published: March 2022

The complexity of local wisdom, way of life, and community beliefs have encouraged the growth and development of indigenous and cultural diversity which can later support tourism development. However, it can also be denied that the Tabanan community will present various natural phenomena with various kinds of things that can cause various conflicts with local wisdom in the community. The results of this study indicate that it is necessary to empower traditional villages by combining traditional village programs with innovative local government programs, by making innovations and creations, both in the fields of creativity, taste, and initiative, by involving the participation of the community so that people's love for culture grows. There have been changes in the social, cultural, and economic fields of society, lifestyles, and economic systems that continue to develop following the flow of globalization. Modernization causes changes in various fields of values, attitudes, and similarities to the realities faced by traditional villages, objects that were previously converted into something that has an exchange value, innovation and commercialization are carried out for tourism connoisseurs, social changes that always change society from one level to another other level, by innovating and creating.
High-Order Surrogacy for the Audiovisual Display of Dance
Authors: Kalonaris Stefano , Zannos Iannis
Published: March 2022

The current pandemic (COVID-19) has had considerable impact on many fronts, not least on the physical presence of humans, affecting how we relate to one another and to the natural environment. To investigate these two interactions, the notion of surrogacy, originally described by Smalley as remoteness between source and sonic gesture, is considered and extended to include bodily gesture, for the rendering of contemporary dance performances into abstract audiovisual compositions/objects. To this end, for a given dance performance, sonification of the motion capture data is combined with video-frame processing of the video recording. In this study, we focus on higher order surrogacy and associate this with 1) a soundscape ecology-inspired approach to sonification, whereby three species of sounds coexist and adapt in the environment according to the symbiotic paradigm of mutualism, and 2) a wave space method to sonify their coevolution. Aesthetic implications of this procedure in the context of multimodal, telematic/remote and virtual systems are discussed as disembodied presence emerges as a dominant trope in our daily experience.
Auditory Notification of Customer Actions in a Virtual Retail Environment: Sound Design, Awareness and Attention
Authors: Falkenberg Kjetil , Frid Emma , Eriksson Martin Ljungdahl , Otterbring Tobias , Daunfeldt Sven-Olov
Published: March 2022

In this paper, we introduce sonification as a less intrusive method for preventing shoplifting. Music and audible alerts are common in retail, and auditory monitoring of a store can aid clerks and reduce losses. Despite these potential advantages, sonification of interaction with goods in retail is an undeveloped field. We conducted an experiment focusing on peripheral auditory notifications in a virtual retail environment, evaluating aspects such as awareness and attention, sound design and noticeability, and localization of event sounds. Results highlighted behavioral differences depending on whether users were informed about the presence of auditory notification sounds or not. The alerts did not cause distraction or annoyance and we suggest that the findings give a promising starting point for future studies and investigations focused on improving the auditory environments in retail.
Highcharts Sonification Studio: An Online, Open-Source, Extensible, and Accessible Data Sonification Tool
Authors: Cantrell Stanley J. , Walker Bruce N. , Moseng Øystein
Published: March 2022

The Highcharts Sonification Studio is the culmination of a multi-year collaboration between Highsoft—the makers of Highcharts—and the Georgia Tech Sonification Lab, to develop an extensible, accessible, online spreadsheet and multimodal graphing platform for the auditory display, assistive technology, and STEM education community. The Highcharts Sonification Studio leverages advances in auditory display and sonification research as well as over 20 years of experience gained through developing the original Sonification Sandbox. We discuss the iterative design and evaluation process of the Highcharts Sonification Studio to ensure usability and accessibility, and highlight opportunities for growth of the tool and its use for research, art, and education within the ICAD community and beyond.
Portable Realtime Volcano Infrasound Auditory Display Devices
Authors: Apel Ted , Johnson Jeffrey B.
Published: March 2022

Active open-vent volcanoes produce intense infrasound airwaves, and volcanoes with prominent craters can create strongly resonant signals, which are inaudible to humans, and often peak around 1 Hz. Study of volcano infrasound is used to model eruption dynamics, the structure of volcanic craters, and can be used as a component of volcano monitoring infrastructure. We have developed a portable on-site real-time sonification device that emits an audible sound in response to an infrasonic airwave. This device can be used near an active volcano both as a real-time educational aid and as an accessible tool for monitoring the state of volcano activity. This paper presents this device with its hardware and software implementation, its parameter mapping sonification algorithm, recommendations for its use in the field, and strategies for future improvements.
Evaluating the Spatial Sonification of the Molecular Structures of Amino Acids Using Multiple Concurrently Sounding Sources
Authors: Liu Danyi , van der Heide Edwin
Published: March 2022

We have designed an interactive form of sonification in which the listener navigates through the molecular structures of amino acids over the network of carbon atoms. We use pitch and density as the two main features for the sound design of the four common chemical elements (H, C, N, O). We use multiple concurrently sounding sources to spatially sonify the atoms around a certain carbon atom of the amino acids. The main goal of this paper is to evaluate this sonification approach. We cover the design, execution and evaluation of two separate cycles of experiments that aim to evaluate our sonification approach and get insight in factors that may influence the individual performance of the concurrently sounding source identification and localization.
Data and Information Transmission in the Context of Sonfication
Authors: Bakogiannis Konstantinos , Polychronopoulos Spyros , Andreopoulou Areti , Georgaki Anastasia
Published: March 2022

This paper illustrates the significance of the concept of information as a tool to expound sonification design. Previous works approached the concept of information systematically. However, its structural characteristics during the process of sonification have not been thoroughly discussed. In order to address the above, this paper presents a framework based on the definition of information from the fields of physics, communication engineering, cybernetics, and systems theory. According to this framework, the representation of a phenomenon into organized sound becomes possible by the propagation of organization within the components of the sonification communication model. Moreover, a distinction between the terms data and information is proposed and related to well-established sonification techniques (Audification, PMSon, MBS). The structural characteristics of the phenomenon (described in terms of entropy) are linked with sonification functions leading to new perspectives of sonification design.
Tiltification - An Accessible App to Popularize Sonification
Authors: Asendorf Malte , Kienzle Moritz , Ringe Rachel , Ahmadi Fida , Bhowmik Debaditya , Chen Jiumeng , Huynh Kelly , Kleinert Steffen , Kruesilp Jatawan , Lee Ying Ying , Wang Xin , Luo Wei , Jadid Navid Mirzayousef , Awadin Ahmed , Raval Varun , Schade Eve Emily Sophie , Jaman Hasanur , Sharma Kashish , Weber Colin , Winkler Helena , Ziemer Tim
Published: March 2022

This paper presents Tiltification, a multi modal spirit level application for smartphones. The non-profit app was produced by students in the master project “Sonification Apps” in winter term 2020/21 at the University of Bremen to learn how to conceptualize, implement, market and test smartphone apps. In the app, psychoacoustic sonification is used to give feedback on the device’s rotation angles in two plane dimensions, allowing users to level furniture or take perfectly horizontal photos. Tiltification supplements the market of spirit level apps with detailed auditory information presentation. This provides for additional benefit in comparison to a physical spirit level and for more accessibility for visually and cognitively impaired people. We argue that the distribution of sonification apps through mainstream channels is a contribution to establish sonification in the market and make it better known to users outside the scientific domain.
Data Mining / Live Scoring – A Live Acoustic Algorithmic Composition Based on Twitter
Authors: Drymonitis Alexandros , Chatzopoulou Nicoleta
Published: March 2022

Data Mining / Live Scoring is a live algorithmic composition for a six member acoustic ensemble. The algorithm receives feed from the popular social platform Twitter, sonifying the tweets it receives by writing a score for each of the six musicians. The concept behind this performance is to create a musical composition which can serve as a soundtrack for Twitter, depending on what is written by the users. Based on the sentiment of the tweets and a musical library written especially for this project, the algorithm attempts to create a score which reflects the mood on Twitter in an abstract way. This project was commissioned by the Onassis Cultural Centre in Athens, and was presented there twice in April 2019. It was realized for the ARTéfacts Ensemble.
Designing Historically Informed Soundscapes for the Augmentation of Modern Travel-Guides: Challenges and Compromises
Authors: Dedousis Giorgos , Katsantonis Konstantinos , Georgaki Anastasia , Andreopoulou Areti
Published: March 2022

The design of immersive soundscape experiences, both for artistic and informative purposes, is an established field in Auditory Display. This paper describes the process of designing historically informed soundscapes to be incorporated in modern travel-guide applications. The work stems from the research project TRACCE (TRavelogue with Augmented Cultural & Contemporary Experience), which focuses on the design and development of a platform for augmented cultural routes. Using this platform, hikers can follow the journey of 18th and 19th century travelers, having access to the original travelogues, tracked routes, and a wide variety of modern information. User experience is augmented by means of visual and auditory reconstructions of the original surrounding environments in several identified points of interest in each path. Apart from the creative process and technical details, the paper discusses the design challenges, which mainly stem from a) the limited data available which would allow an accurate and convincing reconstruction of the acoustic environments, b) the need for diverse auditory displays which would grasp the users’ attention, and c) the difficulty in designing soundscapes which would be interesting, appropriate, and informative for a wide audience of various age groups, educational backgrounds, and sensory abilities.
Two-stage Gamma Knife radiosurgery for brain metastases
Authors:   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Medvedeva K.E. , Baulin A.A. ,   High-precision Radiology Center Gamma-Clinic (Gamma-Medtechnologii LLC), Lepilina O.G. ,   A. Tsyb Medical Radiological Research Centre – branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation (A. Tsyb MRRC), Kvashnin K.M. ,   High-precision Radiology Center Gamma-Clinic (Gamma-Medtechnologii LLC), Ilyalov S.R. ,   High-precision Radiology Center Gamma-Clinic (Gamma-Medtechnologii LLC)
Published: March 2022

The aim of this study was to assess the efficacy and safety of two-stage stereotactic radiosurgery using Gamma Knife for treatment of brain metastases. Staging was applied to patients with large metastases, as well as to metastases located near critical structures. In a group of 31 patients, treatment was carried out in 2 stages with 2-4 weeks interval. The mean tumor volume at the time of the first radiosurgery was 10.4 cm3 (0.52 to 19.07; 95% CI: 8.2-12 cm3). The marginal dose at the first and second stages of radiosurgery ranged from 12 to 14.4 Gy, respectively. Median fol-low-up time was 169 days. Overall survival rate, local control, the incidence of complications, as well as changes in functional status were evaluated. Decrease in volume of tumors between irra-diation sessions averaged 36.2%. Overall survival at 3, 6, 12 months was 70, 57.7 and 52%, re-spectively. Local control after 3, 6, 12 months was 92, 87 and 66%, respectively. Radionecrosis was found out in 2 patients. Increase of Carnovsky index in study group after treatment was by an average of 10 points (p=0.007). Thus, two-stage trained stereotactic radiosurgery can be a safe and effective alternative to surgical treatment of brain metastases without worsening the neuro-logical status of patients.
Sixty years of manned space flight in the light of Russian legislation in the field of ra-diation safety. Basic principles in the ICRP recommendations and in Russian law. Part 1 (in the order of discussion)
Authors:   FSE Research and Technical Center of Radiation-Chemical Safety and Hygiene of the FMBA of Russia, Sakovich V.A.
Published: March 2022

This article is the first of two interrelated ones, which, in the order of discussion, compare the 60-year evolution of the regulation of radiation safety of space flights (RSSF) and radiation safety (RS) in ground conditions from the position of the basic principles of ensuring RS. To do this, a method of quoting excerpts from relevant documents has been chosen. The first article states that, although dose limits have consistently decreased over the years, they have been estab-lished in accordance with basic principles. Without denying the positive methodological role of the principles, the author now considers the inclusion of their wording in legal and regulatory documents unnecessary.
Исследование процессов считывания изображений тепловых объектов приемником, выполненным в архитектуре электронно-оптического преобразователя
Authors: Гревцев А.C. , Золотухин П.А. , Ильичев Э.А. , Петрухин Г.Н. , Попов А.В. , Рычков Г.С.
Published: March 2022

The results of calculations of electric fields, potentials, and trajectories of photoelectrons of the reading node of the receiver of images of thermal objects with the electron-optical converter architecture are presented. The values of the optimal potentials on the control electrodes (microchannel plate, reading electrode, and photocathode) that form a picture of the images of objects and ensure the correct reading of the potential relief from the surface of the sensor-converter pyroelectric film of the image receiver under discussion are determined
Моделирование сбора сырых" проекционных данных в однофотонной эмиссионной компьютерной томографии
Authors: Гурко М.А. , Денисова Н.В.
Published: March 2022

The statistical modeling software package of the data acquisition at examining patients by single-photon emission computed tomography has been developed and tested. The modeling was performed by the Monte Carlo method and included the interaction effects of gamma radiation with matter under radiation transferring through biological tissues and through the collimator-detector system. The calculation of the gamma quanta transferring through the collimator has been verified by simulating clinical "syringe test". Using the developed software package and the anthropomorphic mathematical model simulates a "virtual patient", the acquisition of "raw" projection data has been performed under conditions close to clinical practice. The images obtained are in agreement with clinical data.
Газочувствительность наноструктурированных покрытий на основе наностержней оксида цинка при комбинированной активации
Authors: Рябко А.А. , Бобков А.А. , Налимова С.С. , Максимов А.И. , Левицкий В.С. , Мошников В.А. , Теруков Е.И.
Published: March 2022

This paper presents a study of the gas sensitivity of a nanostructured zinc oxide coating to isopropyl alcohol vapor during heating, ultraviolet irradiation, as well as simultaneous heating and irradiation. Simultaneous heating to 150 °C and ultraviolet irradiation ensures an increase in the sensor layer response. A 10-fold decrease in the power consumption of an ultraviolet light-emitting diode results in a 1.2-fold decrease in the response of the sensor coating. Reducing the operating temperature of a gas sensor with low power consumption and achieving the required sensitivity can provide adsorption sensors integration into portable devices for monitoring ambient air quality.
Guía para la toma de muestras y la identificación de plagas y enfermedades en abejas Apis mellifera: Identificación y toma de muestras en apiarios
Authors: Numa Vergel Stephanie Johana , Gómez Vargas Yolanda , Cepeda Granados Mónica , Santos Díaz Adriana Marcela
Published: March 2022

Esta cartilla describe la forma en que un apicultor debe tomar muestras en colmenas para obtener un diagnóstico adecuado que le sirva como herramienta en la toma de decisiones para el manejo sanitario y el mejoramiento de la productividad y el bienestar de las abejas.
Detección de Agave angustifolia y Agave cupreata con técnicas geomáticas en Guerrero, México
Authors: Olvera-Vargas Luis Alberto , Pardo-Nuñez Joaliné , Aguilar-Rivera Noé , Contreras-Medina David Israel
Published: March 2022

La planta del agave tiene un significativo valor económico y cultural, pues no solo se considera un producto agrícola y forestal, sino que además se emplea en la elaboración de una cantidad importante de productos. En México, uno de los derivados más representativos del agave son las bebidas destiladas de mezcal y tequila, cuya venta se ha incrementado fuera del país. En respuesta a esta demanda, Guerrero ha reportado un crecimiento anual de la producción de mezcal del 1,5 %, con un aumento en la superficie de más de 1.000 hectáreas entre 2015 y 2020. Este auge comercial ha generado una expansión e intensificación de la siembra y producción de la Agave spp. (Asparagaceae), así como el uso de técnicas agrícolas de producción inadecuadas y cambios en la tecnología tradicional. Es por ello que el objetivo de este trabajo fue localizar espacialmente el agave mezcal, en particular las especies Agave cupreata Trel. & Berger y Agave angustifolia Haw., con tecnologías geomáticas para identificar los ambientes diversificados del agave (silvestre o cultivado) que fortalezcan los procesos agroproductivos y potencien los subproductos del cultivo. El estudio encontró que la superficie potencial del cultivo de agave es superior a lo reportado por fuentes oficiales en más de 25.000 hectáreas y que los cálculos realizados con tecnologías geomáticas tienen una precisión del 91 % para identificar áreas adecuadas para el aprovechamiento y la conservación de estas dos especies de importancia económica.
Online Knowledge Translation Program Involving Video Games and University Student–Led Tutorials About Cannabis and Psychosis for Black Youth: Mixed Method Feasibility Study
Authors: Jani Payal , Song Nuri , Artna Erin , Lyeo Joonsoo , Assam Ashley , Maelzer Faith , Murphy Andriene , Grant Angelo , Archie Suzanne
Published: March 2022

Background

We have piloted a new online knowledge translation (KT) program created to educate youth about cannabis effects, which uniquely focuses on mental health risks for Black youth. Youth are generally unaware of the research linking underage usage and the risk of psychosis. Youth from some Black racialized communities in Ontario may be disproportionately affected and in need of this knowledge.

Objective

Because very little is known about the acceptability and feasibility of programs educating Black youth about cannabis and psychosis risk, we evaluated this KT program, which consists of tutorials facilitated by university students and video games.

Methods

This mixed methods pilot study evaluates the transfer of knowledge about cannabis and psychosis risk before and after the online KT program and, at the same time, explores participant satisfaction with the program and views about underage use. Eligible participants were youth 16-19 years of age of Black African or Caribbean descent. Trained undergraduate students from McMaster University administered a quiz (psychosis and cannabis test; PCT) to evaluate knowledge before and after the KT program. After playing the psychoeducational video games, participants attended two tutorial group sessions led by undergraduate students. The undergraduate students facilitated the online tutorials about cannabis and psychosis. The tutorials augmented the educational content embedded within the gameplay: participants discussed what they learned from the video games and their understanding of psychosis and the effects of cannabis. In addition, undergraduate students qualitatively analyzed the tutorial discussions for themes, and the prequiz and postquiz scores were analyzed for significant differences in scores.

Results

A total of 9 Black youth were recruited and completed this pilot study. The mean PCT scores were 5.67 (SD 1.7) and 7.78 (SD 1.8) before and after the KT program, respectively. There was a significant improvement in scores (P<.05) post-KT program. Thematic analysis of the facilitated tutorials revealed three major themes: video game satisfaction, marijuana and psychosis literacy, and help-seeking awareness. Overall, participants showed an increased awareness and understanding of the subject matter after the gameplay and tutorial intervention.

Conclusions

When supplemented with tutorial sessions, the Back to Reality Series shows promise for addressing the gap in knowledge about cannabis and psychosis, and the results provide preliminary evidence that the games appeal to Black youth.
Wearables in Schizophrenia: Update on Current and Future Clinical Applications
Authors: Fonseka Lakshan N , Woo Benjamin K P
Published: March 2022

Schizophrenia affects 1% of the world population and is associated with a reduction in life expectancy of 20 years. The increasing prevalence of both consumer technology and clinical-grade wearable technology offers new metrics to guide clinical decision-making remotely and in real time. Herein, recent literature is reviewed to determine the potential utility of wearables in schizophrenia, including their utility in diagnosis, first-episode psychosis, and relapse prevention and their acceptability to patients. Several studies have further confirmed the validity of various devices in their ability to track sleep—an especially useful metric in schizophrenia, as sleep disturbances may be predictive of disease onset or the acute worsening of psychotic symptoms. Through machine learning, wearable-obtained heart rate and motor activity were used to differentiate between controls and patients with schizophrenia. Wearables can capture the autonomic dysregulation that has been detected when patients are actively experiencing paranoia, hallucinations, or delusions. Multiple platforms are currently being researched, such as Health Outcomes Through Positive Engagement and Self-Empowerment, Mobile Therapeutic Attention for Treatment-Resistant Schizophrenia, and Sleepsight, that may ultimately link patient data to clinicians. The future is bright for wearables in schizophrenia, as the recent literature exemplifies their potential to offer real-time insights to guide diagnosis and management.
Sociotechnical Factors Affecting Patients’ Adoption of Mobile Health Tools: Systematic Literature Review and Narrative Synthesis
Authors: Jacob Christine , Sezgin Emre , Sanchez-Vazquez Antonio , Ivory Chris
Published: March 2022

Background

Mobile health (mHealth) tools have emerged as a promising health care technology that may contribute to cost savings, better access to care, and enhanced clinical outcomes; however, it is important to ensure their acceptance and adoption to harness this potential. Patient adoption has been recognized as a key challenge that requires further exploration.

Objective

The aim of this review was to systematically investigate the literature to understand the factors affecting patients’ adoption of mHealth tools by considering sociotechnical factors (from technical, social, and health perspectives).

Methods

A structured search was completed following the participants, intervention, comparators, and outcomes framework. We searched the MEDLINE, PubMed, Cochrane Library, and SAGE databases for studies published between January 2011 and July 2021 in the English language, yielding 5873 results, of which 147 studies met the inclusion criteria. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines and the Cochrane Handbook were followed to ensure a systematic process. Extracted data were analyzed using NVivo (QSR International), with thematic analysis and narrative synthesis of emergent themes.

Results

The technical factors affecting patients’ adoption of mHealth tools were categorized into six key themes, which in turn were divided into 20 subthemes: usefulness, ease of use, data-related, monetary factors, technical issues, and user experience. Health-related factors were categorized into six key themes: the disease or health condition, the care team’s role, health consciousness and literacy, health behavior, relation to other therapies, integration into patient journey, and the patients’ insurance status. Social and personal factors were divided into three key clusters: demographic factors, personal characteristics, and social and cultural aspects; these were divided into 19 subthemes, highlighting the importance of considering these factors when addressing potential barriers to mHealth adoption and how to overcome them.

Conclusions

This review builds on the growing body of research that investigates patients’ adoption of mHealth services and highlights the complexity of the factors affecting adoption, including personal, social, technical, organizational, and health care aspects. We recommend a more patient-centered approach by ensuring the tools’ fit into the overall patient journey and treatment plan, emphasizing inclusive design, and warranting comprehensive patient education and support. Moreover, empowering and mobilizing clinicians and care teams, addressing ethical data management issues, and focusing on health care policies may facilitate adoption.
Response to Letter to the Editor (Preprint)
Authors: Aminoff Hedvig
Published: March 2022

UNSTRUCTURED

There is no abstract as this is a response to a letter to the editor
What Works Where and How for Uptake and Impact of Artificial Intelligence in Pathology: Review of Theories for a Realist Evaluation (Preprint)
Authors: King Henry , Wright Judy , Treanor Darren , Williams Bethany , Randell Rebecca
Published: March 2022

BACKGROUND

There is increasing interest in the use of artificial intelligence (AI) in pathology to increase accuracy and efficiency. To date, studies of clinicians’ perceptions of AI have found only moderate acceptability, suggesting the need for further research regarding how to integrate it into clinical practice.

OBJECTIVE

The aim of the study was to determine contextual factors that may support or constrain the uptake of AI in pathology.

METHODS

To go beyond a simple listing of barriers and facilitators, we drew on the approach of realist evaluation and undertook a review of the literature to elicit stakeholders’ theories of how, for whom, and in what circumstances AI can provide benefit in pathology. Searches were designed by an information specialist and peer-reviewed by a second information specialist. Searches were run on the arXiv.org repository, MEDLINE, and the Health Management Information Consortium, with additional searches undertaken on a range of websites to identify gray literature. In line with a realist approach, we also made use of relevant theory. Included documents were indexed in NVivo 12, using codes to capture different contexts, mechanisms, and outcomes that could affect the introduction of AI in pathology. Coded data were used to produce narrative summaries of each of the identified contexts, mechanisms, and outcomes, which were then translated into theories in the form of context-mechanism-outcome configurations.

RESULTS

A total of 101 relevant documents were identified. Our analysis indicates that the benefits that can be achieved will vary according to the size and nature of the pathology department’s workload and the extent to which pathologists work collaboratively; the major perceived benefit for specialist centers is in reducing workload. For uptake of AI, pathologists’ trust is essential. Existing theories suggest that if pathologists are able to “make sense” of AI, engage in the adoption process, receive support in adapting their work processes, and can identify potential benefits to its introduction, it is more likely to be accepted.

CONCLUSIONS

For uptake of AI in pathology, for all but the most simple quantitative tasks, measures will be required that either increase confidence in the system or provide users with an understanding of the performance of the system. For specialist centers, efforts should focus on reducing workload rather than increasing accuracy. Designers also need to give careful thought to usability and how AI is integrated into pathologists’ workflow.
VRG Program Evaluation 2021. Self-Evaluation Report by the WWTF Office
Authors:   WWTF, Lasinger Donia , Stampfer Michael , Steinkogler Petra , Strassnig Michael
Published: March 2022

This self-evaluation report contains information about the VRG program. It serves as an input for the 2021 evaluation of WWTF’s Vienna Research Groups for Young Investigators (VRG) program by an international review panel. The VRG program has been financed by the City of Vienna and implemented by the Vienna Science and Technology Fund (WWTF) since 2010.
Bridging the gap between oncology clinical trials and real-world data: evidence on replicability of efficacy results using German claims data
Authors: Ghiani Marco , Maywald Ulf , Wilke Thomas , Heeg Bart
Published: March 2022

Aims:
Using German claims, the authors replicated the CHAARTED trial in metastatic hormone-sensitive prostate cancer.
Methods:
The authors identified metastatic hormone-sensitive prostate cancer patients replicating the inclusion/exclusion criteria of CHAARTED. Patients treated with docetaxel in combination with androgen deprivation therapy (ADT) at first line (docetaxel group) were compared with patients treated with ADT monotherapy (ADT mono group). After propensity score matching, overall survival was compared between the matched cohorts.
Results:
The authors included 441 patients. After propensity score matching, two equally sized matched cohorts of 74 patients each were compared in terms of overall survival. The hazard ratio (HR) was 0.71 (95% CI: 0.42–1.19), comparable to the HR in CHAARTED (HR: 0.72; 95% CI: 0.59–0.89).
Conclusions:
Using early comparative evidence from real-world data for regulatory and health technology assessment decisions is useful.
Reflexiones transdisciplinares para el estudio del cuerpo y la danza. Un caso en el Tucumán (Jujuy, s. XVIII-XIX)
Authors: Koeltzsch Grit Kirstin , Cruz Enrique Normando
Published: March 2022

El concepto de cuerpo y de la danza se ha establecido como clave en las humanidades y ciencias sociales como campo de estudio heterogéneo, porque implica considerar la confluencia de la percepción corporal transmitida del pasado y la articulación con la reflexión teórica contemporánea. Para ejemplificar esta relación, en este artículo realizamos algunas reflexiones teóricas transdisciplinares desde la antropología, la historia del arte, la lingüística, la autoetnografía y la historia social, sobre el cuerpo y la danza en la modernidad occidental; y las aplicamos a una amplia muestra de documentos históricos originales, elaborada a partir de las disposiciones locales del cabildo de una pequeña ciudad del Tucumán en los siglos XVIII-XIX. Con el objetivo de precisar nuevas fuentes y desarrollar interpretaciones sobre el baile y el cuerpo en un espacio y periodo aun no considerado por los estudios regionales de la Argentina.
Salomón de la Selva y Pedro Henríquez Ureña: notas sobre una amistad cultural
Authors: Suárez Turriza Tatiana De los Reyes
Published: March 2022

Este artículo tiene el objetivo de reconstruir y comentar algunos pasajes significativos de la amistad cultural entre Salomón de Selva y Pedro Henríquez Ureña; y se ocupa con particular énfasis en la trayectoria intelectual del poeta nicaragüense. A partir de la revisión de documentos (manuscritos, cartas y artículos periodísticos) rescatados de archivos personales de los autores, se da cuenta de sus afinidades ideológicas, entre las que destaca el panamericanismo, y de sus tendencias artísticas como el modernismo y la cultura clásica grecolatina. El análisis de esos mismos documentos esclarece, además, los posibles motivos de la escasa atención que la crítica mexicana prestó durante mucho tiempo a la obra literaria de Salomón de la Selva, así como a su labor educativa y política.
Patogenicidad de las cepas nativas de Fusarium solani en plantas de algodón transgénico en Baja California, México
Authors: Gonzalez-Soto Tania , Troncos-Rojas Rosalba , Gonzalez-Mendoza Daniel , Mendez-Trujillo Vianey
Published: March 2022

La producción de cultivo de algodón en el Valle de Mexicali se ve afectada principalmente por enfermedades que marchitan y pudren la raíz, y son asociadas al hongo Fusarium spp. El presente trabajo tuvo como objetivo evaluar el efecto de la inoculación de Fusarium solani en cuatro cepas y conocer el porcentaje de la severidad del daño en plántulas de algodón transgénico. Los resultados indicaron que las cepas T-ICA03 y T-ICA01 presentaron un 90% de daños, así como un mayor número de puntos de infección en el sistema radicular en comparación con las otras cepas evaluadas. En plantas de 20 días de edad se determinó la eficiencia fotosintética y clorofílica observando cambios significativos entre las cepas inoculadas y el control durante el experimento. Ambos parámetros fisiológicos explican los posibles efectos de la infección a nivel del transporte de nutrientes y agua que impacta negativamente al sistema fotosintético de la planta. No obstante, debido a su especificidad, se recomienda principalmente el uso de la eficacia fotosintética como un parámetro no destructivo para evaluar el daño a nivel del fotosistema causado por la infección de F. solani en las plantas de algodón transgénico.
Strengthening of RC Column Using GFRP
Authors: Shukla Shubham , Waghmare M. V.
Published: March 2022

Abstract: In construction industry, engineers try to find new, better, economical material. Today there are several new techniques observed in the industry. In recent years, the construction industry has seen an increasing demand to reinstate, rejuvenate, strengthen and upgrade existing concrete structures. This may be attributed to various causes such as environment degradation, design inadequacies, poor construction practices, lack of regular maintenance, revision of codes of practice, increase in loads and seismic conditions etc. One of the technique used is the wrapping of damaged and newly constructed columns with GFRP. As GFRP has the properties like high strength, light weight, resistance towards chemicals and salt water, it can be moulded into complex shapes, requires low maintenance etc. The behaviour of fibre reinforced polymer on different shapes of column has been extensively studied, but much less is known about concrete in FRP confined damaged columns. In this project a total of 21 columns are casted, out of which 3 columns are conventional columns, 9 columns are damaged & 9 are newly constructed columns. The columns are wrapped with single, double and triple layer of GFRP. An average increase of 33.21% is observed in damaged single layer wrapped GFRP column and 51.64% in damaged double layer wrapped GFRP column and 62% in damaged triple layer wrapped GFRP column. Similarly, 46.93% of increase in newly constructed single layer wrapped GFRP column and 72.56% of increase in newly constructed double layer wrapped GFRP column and 90.23% of increase in newly constructed triple layer wrapped GFRP column. Keywords: GFRP, damaged column, newly constructed column.
A Literature Review on Hand-written Character Recognition with Neural Network
Authors: Rathore Priti Singh , Kumar Dr. Pawan
Published: March 2022

Abstract: The handwriting styles of the various individuals are unique in this manner; it is truly challenging to recognize the manually written characters. Manually written character acknowledgment is a space of example that has turned into the subject of exploration during the last few decades. The neural organization assumes a significant part in transcribed person acknowledgment. This requires the study and reproduction of Artificial Neural Networks. In Neural Network, every hub plays out a few straightforward calculations and every association passes a sign starting with one hub on then onto the next marked by a number called the "association strength" or weight, demonstrating the degree to which sign is intensified or reduced by the association. Hindi content is written from left to right and from start to finish design. Keywords: Neural network, Handwritten character recognition, Accuracy, Training Time
Prospective green constitution in new and renewable energy regulation
Authors: Qurbani Indah Dwi , Rafiqi Ilham Dwi
Published: March 2022

The format for regulating new and renewable energy in the draft law on new and renewable energy in Indonesia still contains many polemics and problems. This is motivated by various problems of conception and substance in it, such as misconceptions about nomenclature, problems with institutional formats, licensing problems, and the accommodation of nuclear energy. This paper aims to analyze the potential impacts and prospects of energy using a green constitution point of view. This study used normative juridical research with a statutory and conceptual approach. The results show that the environment is the dominant entity affected by energy management and utilization activities, both fossil energy and new renewable energy with different potential impacts. The prospect of a green constitution has been contained in the draft law on new and renewable energy, but it cannot be realized optimally because transition policies in Indonesia still have dual orientations and overlapping arrangements. The principles of a green constitution can be a guiding concept and norm for the format of regulation and implementation of the use and utilization of new and renewable energy so that it is in line with the values ​​of environmental protection and preservation.
RELAÇÃO ENTRE O ESTADO NUTRICIONAL E A QUALIDADE DE VIDA DE ADULTOS E IDOSOS VISANDO MELHORIAS NA SAÚDE
Authors: Jung Tatiana , Kipper Marília , Bruch-Bertani Juliana Paula , Conde Simara Rufatto , Adami Fernanda Scherer , Cappellari Amanda , Rempel Claudete
Published: March 2022

O estado nutricional de cada indivíduo é um aspecto relevante no que se refere ao envelhecimento e à qualidade de vida, visto que tanto a desnutrição como o sobrepeso/obesidade podem comprometer a saúde, acarretando uma série de enfermidades conhecidas como doenças crônicas não transmissíveis (DCNT). Dados recentes (2016 – 2021) mostram alterações no comportamento alimentar por parte da população, geradas pela fragilidade emocional oriundas do distanciamento social e da falta de conscientização de suas necessidades nutricionais. Tais práticas alimentares adotadas por parte destes indivíduos trazem um agravamento das doenças crônicas não transmissíveis, levando a crer que existe uma necessidade iminente de ações em saúde primária visando sanar tais agravamentos, e, com isso, focar nos cuidados integralizados da saúde dos adultos e idosos para um futuro com melhores índices de saúde, qualidade de vida e redução de DNCTs. Objetivo: Identificar a relação entre qualidade de vida e estado nutricional de adultos e idosos socialmente ativos de um município do interior do Rio Grande do Sul. Método: Trata-se de um estudo transversal com 242 adultos e idosos socialmente ativos, sendo avaliados: fator socioeconômico, antropométrico a partir do Índice de Massa Corporal e qualidade de vida (QV). Para avaliação da QV foi aplicado o questionário abreviado World Health Organization Quality of Life (WHOQOLBref). Os resultados foram comparados com estudos dos últimos 6 anos publicados em revistas brasileiras disponíveis na Plataforma CAPES. Resultados: Em relação a qualidade de vida, a maior média entre os escores encontrados foi para o domínio social (77,20±10,31), seguido pelo domínio ambiental (74,51±7,59), psicológico (72,06±9,86) e físico (65,30±13,28). Entre os homens obteve-se médias superiores em todos os domínios quando comparados às mulheres de ambas as idades, tendo resultado significativo apenas no domínio social (p=0,013). Quanto a percepção da qualidade de vida por faixa etária obteve-se diferença significativa no domínio físico (p=008) e em relação ao estado nutricional a menor média foi observada no domínio físico (p=0,218) e a maior no domínio social (p=0,966), contudo sem diferença significativa. Conclusão: O estado nutricional não influenciou a percepção da qualidade de vida de adultos e idosos de um município do interior do Rio Grande do Sul, diferindo dos resultados obtidos nos estudos publicados nos últimos 6 anos.
AVALIAÇÃO DA QUALIDADE DO LEITE CRU REFRIGERADO DE PROPRIEDADES RURAIS DO MUNICÍPIO DE OURO PRETO DO OESTE, RONDÔNIA
Authors: Rodrigues Santana Juliana , Barcelos Valiatti Tiago , De Oliveira Solla Sobral Fabiana , Faria Romão Natália
Published: March 2022

O leite facilita o desenvolvimento de microrganismos patogênicos, devido seu alto valor nutritivo. Enquanto a qualidade do leite é determinada pela contagem bacteriana, a saúde do úbere se relaciona com a contagem de células somáticas. Outro fator importante são as análises físico-químicas influenciadas pela qualidade do leite no momento de produção. Esse estudo tem como finalidade avaliar a qualidade microbiológica, aspectos físico-químicos (determinação de densidade, amido, açúcar, pH, pesquisa de cloro e hipoclorito, teste de hidróxido de sódio, acidez e redutase) e contagem de células somáticas do leite em tanques de resfriamento, no município de Ouro Preto do Oeste-RO e sua adequação aos parâmetros da Instrução Normativa nº62 de 12/2011. Foram avaliados 12 tanques de resfriamento de leite, sendo um total de 24 amostras (parte inferior e superior). Os resultados demonstraram contagem bacteriana em todas as amostras acima de 3,0x105 UFC/ml, valor determinado como regular pela Instrução Normativa nº 62 para a contagem de mesófilos aeróbios. Diferentemente, os resultados fisico-quimicos demonstraram que apenas 10% das amostras não estão dentro dos padrões estabelecidos pela legislação, referente a determinação de densidade, teste de acidez e teste de redutase, quando comparado aos demais testes realizados. Em relação a CCS, apenas as amostras 07, 09 e 10 apresentaram resultados superiores ao recomendado pela Instrução Normativa Nº62, que preconiza resultado inferior a 400.000 células/mL. Conclui-se que é necessário melhor manejo e o armazenamento do leite cru refrigerado a fim de diminuir a proliferação de microorganismos e consequentemente fornecer uma matéria-prima de qualidade para o consumidor.
AVALIAÇÃO NUTRICIONAL E CONSUMO ALIMENTAR DE GESTANTES ATENDIDAS EM PRÉ-NATAL DE ALTO RISCO: REGIÃO METROPOLITANA DE GOIÂNIA E INTERIOR DE GOIÁS
Authors: Rodrigues Alves Carrijo Dayanne , Alves Moraes Priebe Débora Danielle , Ferreira Stringhini Maria Luiza
Published: March 2022

A avaliação nutricional é o primeiro passo da assistência nutricional e é capaz de identificar problemas ligados à nutrição. O objetivo do estudo foi verificar o estado nutricional e o consumo alimentar de gestantes de Goiânia e região metropolitana (GM) e do interior de Goiás (I). Trata-se de um estudo do tipo transversal com abordagem quantitativa, com a participação de 63 pacientes atendidas no pré-natal de alto risco de um hospital público de Goiânia, Goiás. Aplicou-se o Questionário Socioeconômico e o Questionário de Frequência Alimentar (QFA), além de aferição de medidas antropométricas. Para avaliação das variáveis contínuas de normalidade foi realizado o teste de Shapiro-Wilk e, na comparação entre as variáveis e os grupos utilizou-se o teste t de Student, U de Mann-Whitney e ANOVA de uma via. Para as variáveis categóricas utilizamos o teste de qui-quadrado ou o teste exato de Fisher. Os resultados demonstraram que as variáveis socioeconômicas e antropométricas não apresentaram diferenças significativas entre gestantes dos grupos GM e I. O consumo de bebidas alcoólicas (p=0,01) e o tabagismo (p=0,025) foram mais comuns nas gestantes residentes no interior. Não foram encontradas diferenças significativas segundo avaliação do hábito alimentar entre as gestantes, no entanto, o consumo per capita de sal foi elevado quando associado ao diagnóstico nutricional (p= 0,047) e o consumo de frutas apresentou uma correlação negativa com Índice de Massa Corporal (IMC) gestacional. Conclui-se que são necessárias a adoção de estratégias de educação nutricional para esta população, uma vez que existem hábitos pouco favoráveis à gestante e ao feto.