bluuebunny/crossref_metadata_2025 huggingface dataset:
Suç İşlemeye Tahrik Suçu
Authors: YAŞAR Ercan
Published: July 2022

Suç işlemeye tahrik suçunun 765 s. eski TCK düzenlemesinde yer aldığı süreçte sorunlu olduğu ve bunun üzerine çok sayıda çalışmanın yapıldığı görülmektedir. Suça ilişkin düzenleme suç genel teorisi bağlamında sorun teşkil ettiğinden hukuki niteliği üzerinde sayısız tartışma yapılmış ve mevcut düzenleme suç genel teorisi (ceza hukuku genel hükümler) açısından meşrulaştırılmaya çalışılmıştır. 5237 s. TCK düzenlemesine birtakım değişiklikler yapılarak alınan bu suç tipinin 2005 yılından bu yana yeterince tartışılmadığı görüldüğünden eski tartışmalara değinilmek suretiyle mevcut düzenlemelerin ceza hukuku genel hükümler nazariyesindeki hukuki niteliğine açıklık getirilmeye çalışılmıştır.
Wasiat Wajibah Bagi Kerabat Yang Terhalang Mendapatkan Warisan (Sebuah Rechtsvinding)
Authors: Suratman Suratman , Amini Sulasiyah
Published: July 2022

This paper was compiled with the aim of knowing the considerations of relatives who are prevented from getting an inheritance due to different religions through the mandatory will system and the position of the mandatory will in the perspective of Islamic law. The research method used is normative juridical. Based on the results of the study, it was concluded that consideration of relatives who were prevented from obtaining an inheritance due to different religions, still getting inheritance with a mandatory will system was carried out through the argumentum per analogium method. With a mandatory will, the Supreme Court has made a legal step and this is a rechtsvinding. Based on the perspective of Islamic law, the implementation of the mandatory will is in line with the understanding that Islam is a religion that has the aim of applying the principles of justice as stated in the Qur'an and Hadith.
Hubungan Tingkat Pengetahuan Dengan Tingkat Kecemasan Terhadap Covid-19
Authors: Khotimah Hus Nul , Khozaimah Putri Inni , Ulfah Siti Qomariyah
Published: July 2022

Pengetahuan yang baik melakukan protokol kesehatan berdampak terhadap keamanan diri di masa pandemi Covid-19.  Namun  Pengetahuan merupakan salah satu faktor yang dapat mempengaruhi terjadinya ansietas. Ansietas adalah rasa takut dan rasa cemas termasuk bagian dari respon terhadap stress dalam rentan sehat dan tanda bagi seseorang untuk melindungi dari situasi yang berbahaya Orang dengan pengetahuan yang kurang baik tentang protokol kesehatan covid-19 cenderung memiliki kecemasan yang tinggi. Kecemasan yang tinggi bisa berdampak terhadap kesehatan sehingga dapat menurunkan produktifitas dan kualitas hidup seperti daya  imun menurun sehingga menyebabkan demam, flu, batuk, dan pusing. Tujuan penelitian ini untuk mengetahui hubungan pengetahuan santri tentang protokol kesehatan dengan kecemasan santri PP Nurul Jadid Paiton Probolinggo. Metode penelitian ini menggunakan metode survey analitik, instrumennya menggunakan kuesioner pengetahuan dan kuesioner Hamilton Rating Scale for Anxiety ( HRS-A) Analisis pada penilitian ini menggunakan Uji Chi Square. Hasil penelitian ini menunjukkan bahwa bahwa tidak terdapat hubungan yang signifikan antara pengetahuan yang dimiliki remaja tentang Covid-19 dengan tingkat kecemasan yang dialami pada remaja. Oleh sebab itu peneliti selanjutnya dapat mengidentifikasi ulang faktor apa yang menyebabkan kecemasan remaja saat pandemi Covid-19, sehingga dapat dijadikan dasar dalam upaya untuk menangani gangguan mental remaja karena pandemi.
Hubungan Tingkat Pengetahuan Remaja Putri Tentang Kesehatan Reproduksi Dengan Perilaku Menstrual Hygiene
Authors: Amanda Florica
Published: July 2022

Menstrual hygiene merupakan komponen kebersihan reproduksi perorangan berupa tindakan untuk memelihara kesehatan dan kebersihan alat reproduksi pada saat menstruasi. Pengetahuan remaja tentang kesehatan reproduksi masih kurang, karena pengetahuan yang baik merupakan faktor penentu dalam memelihara kesehatan reproduksi. Tujuan penelitian adalah untuk mengetahui Tingkat Pengetahuan Remaja Putri Dengan Derilaku Menstrual Hygiene Siswi Kelas X. Jenis penelitian ini merupakan survey analitik dengan menggunakan rancangan cross sectional. Jumlah sampel penelitian sebanyak 80 orang. Teknik pengambilan sampel yang digunakan adalah total sampling. Pengumpulan data dilakukan di SMA Negeri 1 Kelapa, Bangka Barat, Provinsi Bangka Belitung. Uji statistic yang digunakan ialah uji chisquare. Hasil Analisa univariat untuk sebagian besar nya terdapat 54 responden (66,2%) dengan kategori perilaku menstrual hygiene negatif dan terdapat 44 responden (55,0%) dengan tingkat pengetahuan kurang, hasil uji statistik diperoleh nilai p-value = 0,000 sehingga p < α 0,05, maka Ho ditolak yang berarti ada hubungan antara tingkat pengetahuan remaja putri tentang kesehatan reproduksi dengan perilaku menstrual hygiene pada remaja putri dengan nilai OR antara tingkat pengetahuan kurang dengan tingkat pengetahuan baik OR = 12,667, artinya responden dengan tingkat pengetahuan kurang mempunyai kecendrungan untuk berperilaku negatif 12,6 kali lebih besar dibandingkan responden dengan tingkat pengetahuan baik. Diharapkan penelitian ini bisa menambah pengetahuan tentang cara melakukan menstrual hygiene yang baik bagi remaja putri serta sebagai pemikiran untuk dikembangkan dalam penelitian selanjutnya.
Hubungan Pengetahuan, Frekuensi Menyusui Dan Hisapan Bayi Dengan Produksi ASI
Authors: Sari Anjelina Puspita , Romlah Romlah
Published: July 2022

Cakupan ASI ekslusif ini masih dibawah target pencapaian 80% baik di Dunia maupun di Indonesia. Penelitian ini bertujuan untuk mengetahui hubungan pengetahuan, frekuensi menyusui, dan hisapan bayi dengan produksi ASI. Metode: Jenis penelitian merupakan analitik observasional dengan menggunakan desain cross sectional. Populasi pada penelitian ini semua ibu- ibu menyusui ASI ekslusif dan PASI di wilayah kerja Puskesmas 23 Ilir Palembang. Jumlah sampel dalam penelitian ini 85 responden, data diambil dengan menyebarkan kuesioner. Teknik pengambilan sampel dengan Purposive Sampling. Teknik analisa data menggunakan uji Chi-Square. Hasil: Hasil uji statistic ada hubungan yang signifikan antara penegtahuan ibu dengan produksi ASI (P=0.012), ada hubungan sginifikan antara frekuensi menyusui dengan produksi ASI (P=0.006), dan terdapat hubungan yang signifikan antara hisapan bayi dengan produksi ASI (P=0.094). Kesimpulan dalam penelitian ini adalah ibu perlu memiliki pengetahuan tentang manfaat ASI, sehingga ibu akan sering menyusui bayinya, semakin sering disusui maka produksi ASI pun semakin banyak. Saran petugas-petugas kesehatan tetap memberikan KIE mengenai ASI ekslusif terutama untuk ibu yang belum ada pengalaman dalam memberikan ASI.
Hubungan Tingkat Pengetahuan, Sikap Dan Motivasi Terhadap Kepatuhan Minum Obat Dengan Frekuensi Kekambuhan Pada Pasien Skizofrenia
Authors: Fitri Nurwijaya , Savira Cindy
Published: July 2022

Skizofrenia merupakan penyakit kronis, kompleks, dan heterogen yang mempengaruhi sebagian besar fungsi dari aspek psikologis, dampak yang  berat akibat individu dengan skizofrenia dapat menghancurkan aspek kekeluargaan, peranan dalam lingkup sosial, dan ketergantungan terhadap obat antipsikotik sebagai faktor utama dalam mencegah terjadinya kekambuhan dan munculnya gejala-gejala yang ada pada pasien. Tujuan penelitian ini adalah untuk mengetahui hubungan antara pengetahuan, sikap dan motivasi terhadap kepatuhan minum obat dengan frekuensi kekambuhan pada pasien skizofrenia di Poli Rawat Jalan Rumah Sakit Jiwa Daerah Bangka Belitung Tahun 2021. Penelitian ini menggunakan desain Cross-sectional. Jumlah responden sebanyak 59 orang dengan teknik pengambilan sampel menggunakan quota sampling. Menggunakan analisis statistik uji chi square pada mean dengan tingkat kepercayaan 95%( α = 0,05) hasil penelitian ini yang di dapat ada hubungan pengetahuan (0,017), sikap (0,003) dan motivasi (0,016) dengan kepatuhan minum obat di Poli Rawat Jalan Rumah Sakit Jiwa Daerah Provinsi Bangka Belitung tahun 2021.
Kepatuhan Penderita Diabetes Mellitus Dalam Melaksanakan Diet Dan Terapi Olahraga
Authors: Dwibarto Rendita
Published: July 2022

Pelaksnaan diet DM secara tidak langsung dipengaruhi oleh hasil pendidikan, sumber informasi maupun media massa. Tingkat Keberhasilan dalam pengobatan DM bergantung pada penderita. Penderita DM  di Puskesmas Pundong mengatakan bahwa senam pronalis khusus pasien DM sudah dilakukan setiap minggunya tetapi kadang kurang efektif karena jadwal yang ditentukan tidak sesuai dengan keluarga yang mengantar dan juga ada beberapa faktor yang menghambat pasien untuk datang mengkuti senam prolanis yang sudah di jadwalkan oleh petugas kesehatan yang ada di puskesams tersebut salah satunya adalah Dukungan Keluarga. Jenis metode penelitian menggunakan kuantitatif dengan rancangan cross sectional. Teknik pengambilan sampel menggunakan  purposive sampling dengan jumlah 36  responden dan menggunakan alat ukur kuesioner. Analisis data dengan menggunakan univariat dengan distribusi frekuensi dan bivariat dengan uji chi square. Hasil analisis menunjukan pengaruh pengetahuan, sikap, dukungan petugas, dukungan keluarga terhadap perilaku penderita penderita DM dalam melaksanakan diet dan terapi olahraga DM di area kerja Puskesmas Pundong Yogyakarta menggunakan chi square dengan nilai p sebesar 0,032, 0,008, 0,002, 0,029 yang menunjukan bahwa nilai p<0,005. ada pengaruh antara pengetahuan, sikap, dukungan petugas kesehatan, dukungan keluarga terhadap perilaku penderita DM dalam melaksanakan diet dan terapi olahraga DM di area kerja Puskesmas Pundong Yogyakarta.
Pengaruh Terapi Murottal Q.S Ar Rahman Terhadap Status Hemodinamika Pada Pasien Hemodialisa
Authors: Nurani Rahmawati Dian
Published: July 2022

Penyakit ginjal kronik (PGK) merupakan kerusakan fungsi renal secara irreversible serta progresif dimana kapabilitas tubuh gagal demi melakukan pertahanan metabolisme. Hemodialisis ialah satu dari beberapa pengobatan yang bisa dilakukan, tetapi penderita banyak yang menghadapi komplikasi medis. Masalah yang selalu dialami ialah hipertensi serta hipotensi. Satu dari beberapa metodedalam memperbaiki status hemodinamika yakni terapi murottal Al Qur’an. Tujuan penelitian untuk mengetahui pengaruh terapi murottal Al Qur’an atas status hemodinamika. Riset ini ialah Quasy-Experiment menggunakan pre and post test with control group design. Sampel riset ini sebanyak 38 responden menggunakan teknik simple random sampling. Analisa yang dipakai ialah uji T Test. Hasil riset membuktikan bahwa terjadi, penurunan tekanan darah sistolik (p value 0,000) dan MAP (p value 0,000), HR (p value 0,017) dan RR (p value 0,011) serta tidak terjadi penurunan tekanan darah diastolik (p value 0,112). Kesimpulan riset ini ialah murottal Al Qur’an yang dilakukan selama satu minggu berpengaruh terhadap menurunnya status hemodinamika (tekanan darah sistolik, mean arterial pressure (MAP), heart rate (HR) dan respiratory rate (RR) untuk penderita hemodialisis.
Hubungan Beban Kerja dan Kejenuhan Kerja Terhadap Stres Kerja Perawat
Authors: Ansyah Ardi , Yani Kari
Published: July 2022

Stres kerja merupakan tekanan dari pekerjaan yang dapat mempengaruhi psikologis pekerja. Beberapa faktor penyebab stres kerja yaitu beban kerja dan kejenuhan kerja. Tujuan penelitian ini adalah untuk mengetahui hubungan beban kerja dan kejenuhan kerja terhadap stres kerja perawat. Penelitian ini menggunakan metode kuantitatif dengan pendekatan Cross Sectional. Populasi dalam penelitian ini adalah perawat yang bertugas diruang rawat inap yaitu sebanyak 120 orang dari 7 ruangan. Sampel dalam penelitian ini sebanyak 73 orang dengan teknik pengambilan sampel menggunakan Propotionate stratiefed Random Sampling. Instrumen penelitian ini menggunakan kuesioner stres kerja, beban kerja dan kejenuhan kerja. Penelitian ini menggunakan analisis statistik dengan menggunakan uji Chi-Square pada tingkat kepercayaan 95% (α = 0,05). Hasil dari penelitian ini menunjukkan bahwa pada beban kerja perawat di dapatkan nilai p value = 0,585 dan kejenuhan kerja nilai  p value = 1,000 secara signifikan tidak ada hubungan dengan stres kerja perawat. Saran dari penelitian ini diharapkan dapat menjadi bahan masukan bagi rumah sakit untuk menentukan langkah-langkah dalam pengelolaan stres atau manajemen stres kepada perawat.
Field Performance Assessment of Irradiated Aedes albopictus Males Through Mark–Release–Recapture Trials With Multiple Release Points
Authors: Balestrino Fabrizio , Puggioli Arianna , Malfacini Marco , Albieri Alessandro , Carrieri Marco , Bouyer Jeremy , Bellini Romeo
Published: July 2022

Mark–release–recapture (MRR) trials have been conducted in Northern Italy to evaluate the capacity of radio-substerilized Aedes albopictus males to survive, disperse, and engage in mating in the field. Two MRR sessions with the human landing collection method (HLC) were conducted with the simultaneous release of irradiated males marked with four different pigment colors. The survival and dispersal rates seem to be influenced more by environmental factors such as barriers, shading, and vegetation rather than weather parameters. In this study, we confirmed a positive linear relationship between the sterile adult male’s daily survival rate and the relative humidity previously reported in similar experimental conditions and a different dispersal capacity of the released A. albopictus males in low- (NDVI index <0.4) and high (NDVI index >0.4)-vegetated areas. Consistent with previous studies, A. albopictus males have their maximal dispersion in the first days after release, while in the following days the males become more stationary. The similar field performances obtained with marked and unmarked radio-sterilized and untreated A. albopictus males on similar environments confirm the negligible effects of irradiation and marking procedures on the quality of the males released. The similar sterile to wild (S/W) male ratio measured in high- and low-vegetation areas in the release sites indicates a similar distribution pattern for the wild and the released sterile males. According to the MRR data collected, the Lincoln index estimated different A. albopictus mean population densities in the study areas equal to 7,000 and 3,000 male/ha, respectively.
Endophytes in Lignin Valorization: A Novel Approach
Authors: Mattoo Aroosa Jan , Nonzom Skarma
Published: July 2022

Lignin, one of the essential components of lignocellulosic biomass, comprises an abundant renewable aromatic resource on the planet earth. Although 15%––40% of lignocellulose pertains to lignin, its annual valorization rate is less than 2% which raises the concern to harness and/or develop effective technologies for its valorization. The basic hindrance lies in the structural heterogeneity, complexity, and stability of lignin that collectively makes it difficult to depolymerize and yield common products. Recently, microbial delignification, an eco-friendly and cheaper technique, has attracted the attention due to the diverse metabolisms of microbes that can channelize multiple lignin-based products into specific target compounds. Also, endophytes, a fascinating group of microbes residing asymptomatically within the plant tissues, exhibit marvellous lignin deconstruction potential. Apart from novel sources for potent and stable ligninases, endophytes share immense ability of depolymerizing lignin into desired valuable products. Despite their efficacy, ligninolytic studies on endophytes are meagre with incomplete understanding of the pathways involved at the molecular level. In the recent years, improvement of thermochemical methods has received much attention, however, we lagged in exploring the novel microbial groups for their delignification efficiency and optimization of this ability. This review summarizes the currently available knowledge about endophytic delignification potential with special emphasis on underlying mechanism of biological funnelling for the production of valuable products. It also highlights the recent advancements in developing the most intriguing methods to depolymerize lignin. Comparative account of thermochemical and biological techniques is accentuated with special emphasis on biological/microbial degradation. Exploring potent biological agents for delignification and focussing on the basic challenges in enhancing lignin valorization and overcoming them could make this renewable resource a promising tool to accomplish Sustainable Development Goals (SDG’s) which are supposed to be achieved by 2030.
A Novel, Cardiac-Derived Algorithm for Uterine Activity Monitoring in a Wearable Remote Device
Authors: Mhajna Muhammad , Sadeh Boaz , Yagel Simcha , Sohn Christof , Schwartz Nadav , Warsof Steven , Zahar Yael , Reches Amit
Published: July 2022

Background: Uterine activity (UA) monitoring is an essential element of pregnancy management. The gold-standard intrauterine pressure catheter (IUPC) is invasive and requires ruptured membranes, while the standard-of-care, external tocodynamometry (TOCO)’s accuracy is hampered by obesity, maternal movements, and belt positioning. There is an urgent need to develop telehealth tools enabling patients to remotely access care. Here, we describe and demonstrate a novel algorithm enabling remote, non-invasive detection and monitoring of UA by analyzing the modulation of the maternal electrocardiographic and phonocardiographic signals. The algorithm was designed and implemented as part of a wireless, FDA-cleared device designed for remote pregnancy monitoring. Two separate prospective, comparative, open-label, multi-center studies were conducted to test this algorithm.

Methods: In the intrapartum study, 41 laboring women were simultaneously monitored with IUPC and the remote pregnancy monitoring device. Ten patients were also monitored with TOCO. In the antepartum study, 147 pregnant women were simultaneously monitored with TOCO and the remote pregnancy monitoring device.

Results: In the intrapartum study, the remote pregnancy monitoring device and TOCO had sensitivities of 89.8 and 38.5%, respectively, and false discovery rates (FDRs) of 8.6 and 1.9%, respectively. In the antepartum study, a direct comparison of the remote pregnancy monitoring device to TOCO yielded a sensitivity of 94% and FDR of 31.1%. This high FDR is likely related to the low sensitivity of TOCO.

Conclusion: UA monitoring via the new algorithm embedded in the remote pregnancy monitoring device is accurate and reliable and more precise than TOCO standard of care. Together with the previously reported remote fetal heart rate monitoring capabilities, this novel method for UA detection expands the remote pregnancy monitoring device’s capabilities to include surveillance, such as non-stress tests, greatly benefiting women and providers seeking telehealth solutions for pregnancy care.
Biomimetic synthesis technology for preparation of Fe3O4-encapsulated biochar using in highly efficient peroxodisulfate activation
Authors: Wang Yangyang , Xu Jianfeng , Wang Xiaoshu , Li Tongtong , Zhang Gen , Yan Zheng , Liu Jiancong , Wang Lei
Published: July 2022

The background value of iron in red soil is superior, primarily absorbed and homogeneously encapsulated in harvested biomass. However, this property on the high-value utilization of bionic iron-encapsulated biomass remains unknown. In this study, special biochar (Fe@BC) was obtained from this kind of biomass by one-step pyrolysis method, which was further used to activate peroxydisulfate (PDS) and degrade 2,4-dichlorophenol (2,4-DCP). The results showed that Fe3O4 was formed and homogeneously embedded in biochar at 500oC. Comparing to catalysts prepared by impregnation pyrolysis (Fe/BC), Fe@BC exhibited excellent degradation performance (90.9%, k = 0.0037 min−1) for 2,4-DCP. According to the free radicals quenching studies, hydroxyl radicals (·OH) and superoxide radicals (·O2−) were the dominant reactive oxygen species (ROS) in Fe@BC/PDS system. Importantly, a PDS adsorption model was established, and the electron transport and PDS activation in the core-shell structure were demonstrated by DFT calculations. Therefore, this study could supply a high-performance catalyst and significant implications for high-value biomass utilization in red soil.
Digital Storytelling: A Didactic Approach to Multimodal Coherence
Authors: Meier Stefan
Published: July 2022

The aim of this article is to explain multimodal coherence-making as a transcribing practice and how this can be used to teach multimodal, narrative, and media competences in different genres. In multimodal arrangements, language makes images readable in specific ways and images make language understandable in different ways. This results in an abductive understanding process that can be used in teaching and learning contexts. This idea of meaning-making is based on the social semiotic approach of style. According to the understanding of semiotic meta functions, this approach considers style as the practice of selecting, forming, and composing semiotic resources. These stylistic practices realize a subjective appropriation of discursive and habitual patterns, which are carried out within the semiotic and technological dispositions (affordances) of the situationally used media infrastructures. In this sense, digital storytelling is a multimodal style practice with digital tools. Multimodal storytelling in educational contexts means that teachers and learners are prompted to bring the communicative functions of text, image, video, and audio into narrative coherence. Based on a journalistic Instagram story, this article reconstructs the media-practical, multimodal, and narrative skills that are prototypically necessary. Based on this analysis, these competencies are operationalized to make them usable for new teaching/learning arrangements using digital storytelling.
Development and Validation of a Personalized, Sex-Specific Prediction Algorithm of Severe Atheromatosis in Middle-Aged Asymptomatic Individuals: The ILERVAS Study
Authors: Bermúdez-López Marcelino , Martí-Antonio Manuel , Castro-Boqué Eva , Bretones María del Mar , Farràs Cristina , Torres Gerard , Pamplona Reinald , Lecube Albert , Mauricio Dídac , Valdivielso José Manuel , Fernández Elvira
Published: July 2022

Background

Although European guidelines recommend vascular ultrasound for the assessment of cardiovascular risk in low-to-moderate risk individuals, no algorithm properly identifies patients who could benefit from it. The aim of this study is to develop a sex-specific algorithm to identify those patients, especially women who are usually underdiagnosed.

Methods

Clinical, anthropometrical, and biochemical data were combined with a 12-territory vascular ultrasound to predict severe atheromatosis (SA: ≥ 3 territories with plaque). A Personalized Algorithm for Severe Atheromatosis Prediction (PASAP-ILERVAS) was obtained by machine learning. Models were trained in the ILERVAS cohort (n = 8,330; 51% women) and validated in the control subpopulation of the NEFRONA cohort (n = 559; 47% women). Performance was compared to the Systematic COronary Risk Evaluation (SCORE) model.

Results

The PASAP-ILERVAS is a sex-specific, easy-to-interpret predictive model that stratifies individuals according to their risk of SA in low, intermediate, or high risk. New clinical predictors beyond traditional factors were uncovered. In low- and high-risk (L&H-risk) men, the net reclassification index (NRI) was 0.044 (95% CI: 0.020–0.068), and the integrated discrimination index (IDI) was 0.038 (95% CI: 0.029–0.048) compared to the SCORE. In L&H-risk women, PASAP-ILERVAS showed a significant increase in the area under the curve (AUC, 0.074 (95% CI: 0.062–0.087), p-value: < 0.001), an NRI of 0.193 (95% CI: 0.162–0.224), and an IDI of 0.119 (95% CI: 0.109–0.129).

Conclusion

The PASAP-ILERVAS improves SA prediction, especially in women. Thus, it could reduce the number of unnecessary complementary explorations selecting patients for a further imaging study within the intermediate risk group, increasing cost-effectiveness and optimizing health resources.

Clinical Trial Registration

[www.ClinicalTrials.gov], identifier [NCT03228459].
Kisspeptin in the Prediction of Pregnancy Complications
Authors: Tsoutsouki Jovanna , Patel Bijal , Comninos Alexander N. , Dhillo Waljit S. , Abbara Ali
Published: July 2022

Kisspeptin and its receptor are central to reproductive health acting as key regulators of the reproductive endocrine axis in humans. Kisspeptin is most widely recognised as a regulator of gonadotrophin releasing hormone (GnRH) neuronal function. However, recent evidence has demonstrated that kisspeptin and its receptor also play a fundamental role during pregnancy in the regulation of placentation. Kisspeptin is abundantly expressed in syncytiotrophoblasts, and its receptor in both cyto- and syncytio-trophoblasts. Circulating levels of kisspeptin rise dramatically during healthy pregnancy, which have been proposed as having potential as a biomarker of placental function. Indeed, alterations in kisspeptin levels are associated with an increased risk of adverse maternal and foetal complications. This review summarises data evaluating kisspeptin’s role as a putative biomarker of pregnancy complications including miscarriage, ectopic pregnancy (EP), preterm birth (PTB), foetal growth restriction (FGR), hypertensive disorders of pregnancy (HDP), pre-eclampsia (PE), gestational diabetes mellitus (GDM), and gestational trophoblastic disease (GTD).
The Unified Supplementary Damping Method Based on Voltage-Soured Converter High-Voltage Direct Current Transmission Through Robust Control
Authors: Jinlei Zhu , Yao Zhang , Feixiang Wu , Jiachang Yi , Jiaqi Wu
Published: July 2022

The VSC-HVDC system can damp the inter-area low-frequency oscillation effectively. To enhance the ability of the VSC-HVDC supplementary control, this article proposes a unified low-frequency oscillation controller design using the robustness theory. The unified control strategy uses both the active power control and reactive power control loop of the VSC to expand the supplementary control dimensions. To design the controller, the TLS-ESPRIT identification method is used to obtain the system small signal model and the oscillation characteristic. Based on the model identified out, the linear matrix inequality method based robust control theory is applied for the controller design, and the robust controllers for active power control and reactive power control loop are both designed to improve the control effect. Finally, the simulation results show that the controller can reach better control effect and the robustness can also be guaranteed.
Comprehensive Analysis of the Expression and Prognosis for Tripartite Motif-Containing Genes in Breast Cancer
Authors: Ning Lvwen , Huo Qin , Xie Ni
Published: July 2022

Tripartite motif-containing genes (TRIMs), with a ubiquitin ligase’s function, play critical roles in antitumor immunity by activating tumor-specific immune responses and stimulating tumor proliferation, thus affecting patient outcomes. However, the expression pattern and prognostic values of TRIMs in breast cancer (BC) are not well clarified. In this study, several datasets and software were integrated to perform a comprehensive analysis of the expression pattern in TRIMs and investigate their prognosis values in BC. We found that TRIM59/46 were significantly upregulated and TRIM66/52-AS1/68/7/2/9/29 were decreased in BC and validated them using an independent cohort. The expression of numerous TRIMs are significantly correlated with BC molecular subtypes, but not with tumor stages or patient age at diagnosis. Higher expression of TRIM3/14/69/45 and lower expressions of TRIM68/2 were associated with better overall survival in BC using the Kaplan–Meier analysis. The multivariate Cox proportional hazards model identified TRIM45 as an independent prognostic marker. Further analysis of single-cell RNA-seq data revealed that most TRIMs are also expressed in nontumor cells. Higher expression of some TRIMs in the immune or stromal cells suggests an important role of TRIMs in the BC microenvironment. Functional enrichment of the co-expression genes indicates that they may be involved in muscle contraction and interferon-gamma signaling pathways. In brief, through the analysis, we provided several TRIMs that may contribute to the tumor progression and TRIM45 as a potential new prognostic biomarker for BC.
The molecular mechanisms of CTHRC1 in gastric cancer by integrating TCGA, GEO and GSA datasets
Authors: Zhao Lulu , Wang Wanqing , Niu Penghui , Luan Xiaoyi , Zhao Dongbing , Chen Yingtai
Published: July 2022

Collagen triple helix repeat containing-1 (CTHRC1), highly expressed in multiple human solid tumors, has been identified as a tumor associated protein. However, its specific role and mechanism with immune infiltrates in gastric cancer are still unclear. In this study, we systematically explored and validated the expression and prognostic value of CTHRC1 in gastric cancer by integrating the Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO) and Genome Sequence Archive (GSA) datasets. Compared to adjacent normal tissues, we observed that CTHRC1 was highly overexpressed in tumor sample of multiple cancers. It was revealed that CTHRC1 overexpression was positively correlated with the T stage in gastric cancer but not lymph nodes metastasis from TCGA dataset. In addition, CTHRC1 expression may induce tumor associated macrophage infiltration though GRN/TNFRSF1A and AnxA1/FPR1 pathways and also tumor angiogenesis in gastric cancer. In this context, our results indicate that CTHRC1 plays a pivotal role in regulating the angiogenesis and macrophage infiltration in tumor microenvironment, and also can predict poor prognosis in gastric cancer, suggesting that CTHRC1 might be a promising novel immunotherapy and angiogenesis target for gastric cancer.
A novel mutation in the UBAP1 gene causing hereditary spastic paraplegia: A case report and overview of the genotype-phenotype correlation
Authors: Li Peiqiang , Huang Xiande , Chai Senmao , Zhu Dalin , Huang Huirong , Ma Fengdie , Zhang Shasha , Xie Xiaodong
Published: July 2022

Hereditary Spastic Paraplegia (HSP) is considered to be one of the common neurodegenerative diseases with marked genetic heterogeneity. Recently, the mutations in ubiquitin-associated protein 1 (UBAP1) have been described in patients with HSP, known as spastic paraplegias 80 (SPG80). Here, we reported a Chinese HSP family presenting a frameshift mutation in the UBAP1 gene leading to complex HSP. Their clinical features encompassed spastic paraparetic gait, exaggerated patellar tendon reflexes, bilateral Babinski signs, and hyperactive Achilles tendon reflex. The proband also had severe urinary incontinence and a dermoid cyst at the lumbar 4–5 spinal cord, which rarely occurs in HSP patients. Following whole-exome sequencing, a novel heterozygous mutation (c.437dupG, NM_016,525) was identified in the UBAP1 that segregated with the family’s phenotype and resulted in truncating UBAP1 protein (p.Ser146ArgfsTer13). Moreover, we reviewed the genotypes of UBAP1 and the phenotypic variability in 90 HSP patients reported in the literature. We found that the age of onset in UBAP1-related patients was juvenile, and there were population differences in the age of onset. The main complications were lower extremity spasticity, hyperreflexia, and the Babinski sign. Exon 4 of UBAP1 was identified as a mutation hotspot region. Our study expands the knowledge of UBAP1 mutations, which will aid in HSP patient counseling. Further molecular biological research is needed to explore the genotype-phenotype correlations of UBAP1-related HSP.
Physiological and Differential Proteomic Analysis at Seedling Stage by Induction of Heavy-Ion Beam Radiation in Wheat Seeds
Authors: Li Yuqi , Gu Jiayu , Irshad Ahsan , Zhao Linshu , Guo Huijun , Xiong Hongchun , Xie Yongdun , Zhao Shirong , Ding Yuping , Zhou Libin , Kong Fuquan , Fang Zhengwu , Liu Luxiang
Published: July 2022

Novel genetic variations can be obtained by inducing mutations in the plant which help to achieve novel traits. The useful mutant can be obtained through radiation mutation in a short period which can be used as a new material to produce new varieties with high yield and good quality wheat. In this paper, the proteomic analysis of wheat treated with different doses of 12C and 7Li ion beam radiation at the seedling stage was carried out through a Tandem Mass Tag (TMT) tagging quantitative proteomic analysis platform based on high-resolution liquid chromatography-mass spectrometry, and the traditional 60Co-γ-ray radiation treatment for reference. A total of 4,764 up-regulated and 5,542 down-regulated differentially expressed proteins were identified. These proteins were mainly enriched in the KEGG pathway associated with amino acid metabolism, fatty acid metabolism, carbon metabolism, photosynthesis, signal transduction, protein synthesis, and DNA replication. Functional analysis of the differentially expressed proteins showed that the oxidative defense system in the plant defense system was fully involved in the defense response after 12C ion beam and 7Li ion beam radiation treatments. Photosynthesis and photorespiration were inhibited after 12C ion beam and 60Co-γ-ray irradiation treatments, while there was no effect on the plant with 7Li ion beam treatment. In addition, the synthesis of biomolecules such as proteins, as well as multiple signal transduction pathways also respond to radiations. Some selected differentially expressed proteins were verified by Parallel Reaction Monitoring (PRM) and qPCR, and the experimental results were consistent with the quantitative results of TMT. The present study shows that the physiological effect of 12C ion beam radiation treatment is different as compared to the 7Li ion beam, but its similar to the 60Co-γ ray depicting a significant effect on the plant by using the same dose. The results of this study will provide a theoretical basis for the application of 12C and 7Li ion beam radiation in the mutation breeding of wheat and other major crops and promote the development of heavy ion beam radiation mutation breeding technology.
Safety and Security Issues, Gender-Based Violence and Militarization in the Time of Armed Conflict: The Experiences of Internally Displaced People From Marawi City
Authors: Veloso Diana Therese M.
Published: July 2022

This study delves into the experiences of armed conflict and displacement among civilians, who evacuated from the Islamic City of Marawi to nearby cities and municipalities in Northern Mindanao, as well as other parts of the Philippines, to escape the clashes between ISIS-affiliated extremists and security forces in 2017. Drawing upon in-depth interviews and focus group discussions with survivors of armed conflict and duty-bearers, such as government employees, staff of non-government organizations (NGOs), doctors, faculty members and administrators of educational institutions, and volunteers who aided in relief efforts, this research identifies the safety and security issues and vulnerabilities confronting internally displaced people (IDPs) from Marawi City, who are predominantly racial, ethnic, and religious minorities. This study investigates the trends in and risks for gender-based violence among women and girls and men and boys in conflict zones and the challenges in the promotion of their safety and well-being. This paper examines the dynamics of gender-based violence and the respondents’ experiences of private, community-based, and state-sponsored violence in conflict zones and the risk of further violence upon their return to Marawi City. This research also examines the experiences of militarization among IDPs and their views of Martial Law, which was declared in Mindanao on the first day of the Marawi Siege in May 2017. This study illuminates the nuances in the experiences of IDPs living in traditional evacuation centers and alternative home-based evacuation arrangements, their service needs, and the support systems and interventions available to them. The researcher highlights the links between racial, ethnic, gender, and social class inequality in the Philippines and the vulnerability of IDPs, given their dismal living conditions and the absence of normalization in their lives due to the prolonged siege. This paper highlights the intersections between private and public violence, the human rights issues confronting IDPs from Marawi City, and the local and international responses to their situation.
Activation of STING Based on Its Structural Features
Authors: Hussain Behzad , Xie Yufeng , Jabeen Uzma , Lu Defen , Yang Bo , Wu Changxin , Shang Guijun
Published: July 2022

The cGAS-cGAMP-STING pathway is an important innate immune signaling cascade responsible for the sensing of abnormal cytosolic double-stranded DNA (dsDNA), which is a hallmark of infection or cancers. Recently, tremendous progress has been made in the understanding of the STING activation mechanism from various aspects. In this review, the molecular mechanism of activation of STING protein based on its structural features is briefly discussed. The underlying molecular mechanism of STING activation will enable us to develop novel therapeutics to treat STING-associated diseases and understand how STING has evolved to eliminate infection and maintain immune homeostasis in innate immunity.
Optimisation of anti-interleukin-6 therapy: Precision medicine through mathematical modelling
Authors: Rossi Jean-François , Chiang Hao-Chun , Lu Zhao-Yang , Levon Kalle , van Rhee Frits , Kanhai Karan , Fajgenbaum David C. , Klein Bernard
Published: July 2022

Background

Dysregulated interleukin (IL)-6 production can be characterised by the levels present, the kinetics of its rise and its inappropriate location. Rapid, excessive IL-6 production can exacerbate tissue damage in vital organs. In this situation, therapy with an anti-IL-6 or anti-IL-6 receptor (IL-6R) monoclonal antibody, if inappropriately dosed, may be insufficient to fully block IL-6 signalling and normalise the immune response.

Methods

We analysed inhibition of C-reactive protein (CRP) – a biomarker for IL-6 activity – in patients with COVID-19 or idiopathic multicentric Castleman disease (iMCD) treated with tocilizumab (anti-IL-6R) or siltuximab (anti-IL-6), respectively. We used mathematical modelling to analyse how to optimise anti-IL-6 or anti-IL-6R blockade for the high levels of IL-6 observed in these diseases.

Results

IL-6 signalling was insufficiently inhibited in patients with COVID-19 or iMCD treated with standard doses of anti-IL-6 therapy. Patients whose disease worsened throughout therapy had only partial inhibition of CRP production. Our model demonstrated that, in a scenario representative of iMCD with persistent high IL-6 production not controlled by a single dose of anti-IL-6 therapy, repeated administration more effectively inhibited IL-6 activity. In a situation with rapid, high, dysregulated IL-6 production, such as severe COVID-19 or a cytokine storm, repeated daily administration of an anti-IL-6/anti-IL-6R agent, or alternating daily doses of anti-IL-6 and anti-IL-6R therapies, could neutralise IL-6 activity.

Conclusion

In clinical practice, IL-6 inhibition should be individualised based on pathophysiology to achieve full blockade of CRP production.

Funding

EUSA Pharma funded medical writing assistance and provided access to the phase II clinical data of siltuximab for analysis.
Different Neutralization Profiles After Primary SARS-CoV-2 Omicron BA.1 and BA.2 Infections
Authors: Medits Iris , Springer David N. , Graninger Marianne , Camp Jeremy V. , Höltl Eva , Aberle Stephan W. , Traugott Marianna T. , Hoepler Wolfgang , Deutsch Josef , Lammel Oliver , Borsodi Christian , Puchhammer-Stöckl Elisabeth , Zoufaly Alexander , Weseslindtner Lukas , Aberle Judith H. , Stiasny Karin
Published: July 2022

Background and Methods

The SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) Omicron (B.1.1.529) variant is the antigenically most distinct variant to date. As the heavily mutated spike protein enables neutralization escape, we studied serum-neutralizing activities of naïve and vaccinated individuals after Omicron BA.1 or BA.2 sub-lineage infections in live virus neutralization tests with Omicron BA.1, Omicron BA.2, wildtype (WT, B1.1), and Delta (B.1.617.2) strains. Serum samples obtained after WT infections and three-dose mRNA vaccinations with and without prior infection were included as controls.

Results

Primary BA.1 infections yielded reduced neutralizing antibody levels against WT, Delta, and Omicron BA.2, while samples from BA.2-infected individuals showed almost no cross-neutralization against the other variants. Serum neutralization of Omicron BA.1 and BA.2 variants was detectable after three-dose mRNA vaccinations, but with reduced titers. Vaccination-breakthrough infections with either Omicron BA.1 or BA.2, however, generated equal cross-neutralizing antibody levels against all SARS-CoV-2 variants tested.

Conclusions

Our study demonstrates that although Omicron variants are able to enhance cross-neutralizing antibody levels in pre-immune individuals, primary infections with BA.1 or BA.2 induced mostly variant-specific neutralizing antibodies, emphasizing the differently shaped humoral immunity induced by the two Omicron variants. These data thus contribute substantially to the understanding of antibody responses induced by primary Omicron infections or multiple exposures to different SARS-CoV-2 variants and are of particular importance for developing vaccination strategies in the light of future emerging variants.
A Glance Into Healthcare Delivery During COVID-19 Pandemic: A Survey Among Turkish Medical Doctors
Authors: Karaman Irem , Ildir Selin , Ozkaya Sevket
Published: July 2022

The coronavirus 2019 (COVID-19) pandemic had an enormous impact on healthcare delivery globally. We conducted a cross-sectional online survey in Turkey to evaluate the impact of COVID-19 on healthcare services in Turkey. A 35-item anonymized online survey was completed by HCPs (medical doctors, MD) who continued their clinical practice during the COVID-19 pandemic in Turkey, regardless of their specialties or degrees. Overall, 209 HCPs participated in the study. Forty-two percent of the participants stated that their current workload intensity has been increased compared with the pre-pandemic era. More than half of the participants (54.6%) were using telemedicine services during their clinical practice, however, the effectiveness of telemedicine for first-time patients and follow-up patients was rated as low. The majority of participants (59.3%) reported that during the peak period of the pandemic, they encountered only a small variety of cases, other than COVID-19. Fifty-two percent of the participants agreed that they occasionally had patients who received misdiagnosis in the first admission due to the suspicion of a possible COVID-19 infection predominating the diagnostic process (eg., not excluding COVID-19 even though the PCR test is negative). For the distribution of possible late-diagnosed diseases, 25.8% of HCPs selected chest diseases, followed by infectious diseases, heart diseases, and cancer. In general, participants agreed that there was an increase in the negligence in the follow-up of various diseases and/or complication rates due to COVID-19 pandemic. Sixty percent of the HCPs agreed that HCPs are being much more rigorous to diagnose/treating COVID-19 than other important diseases. Fifty-seven percent of the participants stated that the diagnosis and follow-up of chronic diseases are affected, while 57.9% of the HCPs stated that some diseases that show similar signs and symptoms as COVID-19 are not diagnosed correctly during COVID-19 pandemic. Findings from this study emphasize that COVID-19 pandemic has significantly caused delayed diagnoses and interruption in the management of chronic diseases, and also increased the risk of missing out the diagnosis of non-COVID-19 diseases. The study genuinely aims to yield the floor to a permanent improvement in post-pandemic clinical management and it also shows the need for a focused approach in distinct areas of medical care. Policymaking is required to drive changes to better support HCPs in Turkey.
Exacerbation of Autoimmune Bullous Diseases After Severe Acute Respiratory Syndrome Coronavirus 2 Vaccination: Is There Any Association?
Authors: Kianfar Nika , Dasdar Shayan , Salehi Farid Ali , Balighi Kamran , Mahmoudi Hamidreza , Daneshpazhooh Maryam
Published: July 2022

Background and Aim

There have been concerns regarding the potential exacerbation of autoimmune bullous diseases (AIBDs) following vaccination against COVID-19 during the pandemic. In the current study, vaccine safety was evaluated in patients with AIBDs.

Methods

In this study, patients with AIBDs were contacted via face-to-face visits or phone calls. Patient demographics, vaccine-related information, pre- and post-vaccine disease status, and complications were recorded. The exacerbation was considered either relapse in the remission/controlled phase of the disease or disease worsening in the active phase. The univariate and multivariate logistic regression tests were employed to determine the potential risk factors of disease exacerbation.

Results

Of the patients contacted, 446 (74.3%) reported receiving at least one dose of vaccine injection (54.7% female). Post-vaccine exacerbation occurred in 66 (14.8%) patients. Besides, there were 5 (1.1%) patients with AIBD diagnosis after vaccination. According to the analysis, for every three patients who received vaccines during the active phase of the disease one experienced disease exacerbation. The rate of disease exacerbation increased by three percent with every passing month from the last rituximab infusion. Active disease in the past year was another risk factor with a number needed to harm of 10.

Conclusion

Risk of AIBD exacerbation after the COVID-19 vaccine is not high enough to prevent vaccination. This unwanted side effect, can be reduced if the disease is controlled at the time of vaccination.
Quantization Framework for Fast Spiking Neural Networks
Authors: Li Chen , Ma Lei , Furber Steve
Published: July 2022

Compared with artificial neural networks (ANNs), spiking neural networks (SNNs) offer additional temporal dynamics with the compromise of lower information transmission rates through the use of spikes. When using an ANN-to-SNN conversion technique there is a direct link between the activation bit precision of the artificial neurons and the time required by the spiking neurons to represent the same bit precision. This implicit link suggests that techniques used to reduce the activation bit precision of ANNs, such as quantization, can help shorten the inference latency of SNNs. However, carrying ANN quantization knowledge over to SNNs is not straightforward, as there are many fundamental differences between them. Here we propose a quantization framework for fast SNNs (QFFS) to overcome these difficulties, providing a method to build SNNs with enhanced latency and reduced loss of accuracy relative to the baseline ANN model. In this framework, we promote the compatibility of ANN information quantization techniques with SNNs, and suppress “occasional noise” to minimize accuracy loss. The resulting SNNs overcome the accuracy degeneration observed previously in SNNs with a limited number of time steps and achieve an accuracy of 70.18% on ImageNet within 8 time steps. This is the first demonstration that SNNs built by ANN-to-SNN conversion can achieve a similar latency to SNNs built by direct training.