bluuebunny/crossref_metadata_2025 huggingface dataset:
Religiusitas Dan Resiliensi Pada Perawat Di Timika Papua Di Masa Pandemi COVID-19
Authors: Valentien Feby , Huwae Arthur
Published: March 2023

ABSTRACT: RELIGIOSITY AND RESILLIENCE IN NURSES IN TIMIKA PAPUA DURING COVID-19 PANDEMIC The COVID-19 pandemic can harm nurses and lead to psychological problems when providing services to COVID-19 patients because nurses are the most frequently in contact with COVID-19 patients. To be able to carry out their duties, nurses must have resilience and religiosity to be able to survive, behave and act following the teachings of their religion. Therefore, this study aims to determine the relationship between religiosity and resilience in nurses in Timika Papua during the COVID-19 pandemic. The research method used is quantitative with a correlational design. Participants in the study was 34 nurses, obtained using the purposive sampling technique. The scale used consists of a religiosity scale and a resilience scale. The results showed a significant positive relationship between religiosity and resilience in nurses in Timika Papua. Nurses in Timika Papua can increase good resilience in dealing with COVID-19 patients because they have a high value of religiosity in their lives. Keywords: COVID-19, Nurses, Religiosity, Resilience Pandemi COVID-19 dapat berdampak negatif bagi perawat dan dapat memunculkan masalah psikologis saat memberikan pelayanan terhadap pasien COVID-19, karena perawat yang paling sering berkontak dengan pasien COVID-19. Untuk dapat menjalankan tugasnya, perawat harus memiliki resiliensi dan religiositas agar mampu bertahan, bertingkah laku dan bersikap sesuai dengan ajaran agama yang dianutnya. Maka dari itu, penelitian ini bertujuan untuk mengetahui hubungan antara religiositas dengan resiliensi pada perawat di Timika Papua di masa pandemi COVID-19. Metode penelitian yang digunakan yaitu kuantitatif dengan desain korelasional. Partisipan dalam penelitian berjumlah 34 orang, dengan menggunakan teknik purposive sampling. Skala yang digunakan terdiri dari skala religiositas dan skala resiliensi. Hasil penelitian menunjukkan bahwa terdapat hubungan positif yang signifikan antara religiositas dengan resiliensi pada perawat di Timika Papua. Perawat di Timika Papua mampu meningkatkan resiliensi yang baik dalam menangani pasien COVID-19 karena memiliki nilai religiositas yang tinggi dalam hidupnya. Kata Kunci: COVID-19, Perawat, Religiositas, Resiliensi
Напрями удосконалення професійного розвитку офіцерського складу щодо підвищення бойових спроможностей військ (сил)
Authors: Тіхонов Г. , Кірілкін Є. , Шпанчук Г. , Смірнов І.
Published: March 2023

Характерною рисою сучасного процесу військового будівництва в Україні є його спрямованість на створення європейської моделі Збройних Сил, яка акумулює в собі кращі ознаки сучасних армій, збройних сил демократичної держави, призначених до дій в реаліях XXI століття. Постійне підвищення вимог до рівня підготовленості особового складу, особливо офіцерського складу ЗС України, викликає необхідність забезпечення професійної готовності військовослужбовців до виконання завдань за призначенням. В умовах повномасштабної збройної агресії РФ проти України, реалізації стратегічного курсу України на приєднання до європейсько-атлантичної спільноти, особливої актуальності набувають структурні та системні зміни в організації і підходах до професійного розвитку офіцерського складу військових організаційних структур у системі індивідуального навчання.

Проведений аналіз сучасного стану професійного розвитку офіцерів дав можливості виокремити перспективи імплементації позитивного досвіду практичної спрямованості підготовки військових фахівців. Перспективними напрямами подальшого реформування системи розвитку офіцерського складу є: забезпечення результативного управлінського, кадрового, матеріально-технічного рівня професійного розвитку офіцерів, нарощування співпраці з військовими фахівцями держав – членів НАТО.

Професійний розвиток офіцера буде сприяти якісному виконанню службових обов’язків та підвищенню рівня його професійних знань, що значною мірою залежить від ставлення до цього процесу командирів (начальників) всіх рівнів, посадових осіб органів виховної та соціально-психологічної роботи, служб персоналу та служб забезпечення. Кінцевою метою професійного розвитку офіцерського складу повинно стати підвищення бойових спроможностей військової організаційної структури за рахунок професійного розвитку персоналу.
Поточні механізми реалізації заходів міжнародного військового співробітництва в контексті Угоди про асоціацію між Україною та Європейським Союзом у межах Спільної політики безпеки та оборони
Authors: Войтех О. , Войтех К.
Published: March 2023

В умовах протидії збройній агресії Росії в Україні одним з актуальних напрямів забезпечення воєнної безпеки України є інтеграція до міжнародних безпекових організацій.Ключовим пріоритетом міжнародного військового співробітництва ЗС України в умовах повномасштабного вторгнення Росії в Україну є посилення практичного співробітництва із структурами ЄС у рамках спільної політики безпеки і оборони (СПБО) з питань отримання міжнародної допомоги за напрямами реалізації Угоди про асоціацію між Україною та ЄС [4], ініціативи Східне партнерство [5] та Глобальної стратегії ЄС [6].

Це вимагає визначення механізмів реалізації заходів міжнародного військового співробітництва України із структурами ЄС у рамках СПБО, та їх оцінки.

Мета статті – аналіз механізмів, які впливають на успішність міжнародного військового співробітництва ЗС України із структурами ЄС у сфері СПБО для набуття відповідних оперативних спроможностей ЗС України, забезпечення взаємосумісності із збройними силами інших держав, підготовки особового складу, спрямованих на вирішення національних інтересів України з питань відновлення територіальної цілісності та суверенітету держави.

На сьогодні вже напрацьовано мінімально необхідну законодавчу базу відносин між Україною та ЄС у сфері безпеки.Завдяки добре відпрацьованим у міжнародній практиці механізмам оборонного співробітництва, а також реально існуючим можливостям України з одного боку, та потребам ЄС у додаткових силах та засобах з іншого, співробітництво між Україною та ЄС у військовій сфері на сьогодні вже набуло помітного розвитку.

На завершальному етапі триває підготовка пропозиції сторони ЄС щодо можливого залучення до оборонно-промислових та військових проєктів програми ЄС PESCO, що сприятиме подальшому розвитку військово-технічного та військового потенціалу Збройних Сил України.

На даний час відсутній єдиний методичний підхід визначення факторів, які впливають на ефективність міжнародного військового співробітництва на рівні ЗС України.
Рекомендації щодо визначення кількості та складу мобільних протидиверсійних резервів під час оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил
Authors: Момот Д.
Published: March 2023

Досвід проведення антитерористичної операції (операції об’єднаних сил) демонструє високу ефективність застосування диверсійно-розвідувальних груп (ДРГ) та незаконних збройних формувань (НЗФ) противника на початковому етапі збройного протиборства або до його початку. Враховуючи особливості міжнародних відносин та розвиток воєнно-політичної обстановки довкола нашої країни можна стверджувати,що перші операції об’єднаних сил будуть оборонними. Звідси випливає, що найбільших втрат військовим формуванням оперативного командування та шкоди державній інфраструктурі ДРГ (НЗФ) противника спроможні завдати у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.

Метою статті є розроблення рекомендацій щодо визначення кількості та складу мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.

Під час планування розгортання військ оперативного командування, необхідно передбачити створення достатньої кількості протидиверсійних резервів, які спроможні оперативно та своєчасно прибути до визначеного району, швидко блокувати (нейтралізувати) та знищити ДРГ (НЗФ) противника.

У ході дослідження проведено аналіз особливостей оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил. Проведений аналіз надав можливість визначити специфіку проведення розрахунків щодо створення мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування. Як результат, розроблені рекомендації щодо визначення кількості та складу мобільних протидиверсійних резервів у ході оперативного розгортання військ оперативного командування в інтересах оборонної операції об’єднаних сил.
МАТЕМАТИЧНА МОДЕЛЬ ОЦІНЮВАННЯ ЗМАЩУВАЛЬНОЇ ЗДАТНОСТІ СУДНОВИХ ДИСТИЛЯТНИХ ПАЛИВ
Authors: Мельник Ольга Володимирівна , Сорока В’ячеслав Володимирович , Довгаль Іван Іванович
Published: March 2023

У дослідженні проведено комплексний аналіз, що включає дослідження фізикохімічних та трибологічних властивостей сумішевих палив, а також проведений моторний експеримент дозволили встановити оптимальну концентрацію ПО в СДП. Вона становить 1-3%. Подальше збільшення вмісту ПО недоцільне, оскільки дає незначний триботехнічний ефект, але при цьому погіршуються фізико-хімічні показники композиційного суднового палива. Проведено моторний експеримент на розроблених сумішевих паливах з додаванням ПО, який засвідчив, що їх застосування в СДВЗ не викликає будь-яких значущих змін параметрів робочого процесу двигуна і вони можуть використовуватися без обмежень. Досліджено натурний стенд для випробування ПНВТ, на якому виконано оцінку стану плунжерних пар ПА при роботі на різних типах СДП. Вимірами шорсткості поверхонь у нанометровому діапазоні методами інтерферометрії високої роздільної здатності встановлено негативний вплив НМДП на стан поверхні плунжерних пар ПНВТ. Додавання ПО до НМДП сприяє покращенню їх змащувальної можливості. Знос плунжера знизився на 63,7% порівняно зі втратою маси деталі, що працювала на вихідному НМДТ, а параметри шорсткості Ra та Rz відповідно зменшилися у 2,75 та 4,44 разів. Розроблено високоефективну систему паливопідготовки при роботі на НМДТ, яка за рахунок реалізації комплексу науково-технічних заходів дозволяє мінімізувати процес зношування прецизійних пар ПА за рахунок добавки ПО та одночасного охолодження НМДП АБХМ
Mechanical Thrombectomy for Refractory Cerebral Venous Sinus Thrombosis in a Child with Nephrotic Syndrome : A Case Report
Authors: Ye Jing , Yang Yuan , Wan Weifeng , Ma Xuntai , Liu Lei , Liu Yong , He Zhongchun , Yuan Zhengzhou
Published: March 2023

Nephrotic syndrome (NS) is associated with cerebral venous sinus thrombosis (CVST), which is a rare cerebrovascular disorder in children. Systemic anticoagulation with heparin is the standard therapy for CVST, and mechanical thrombectomy (MT) has been described as a salvage treatment for adult anticoagulant refractory CVST, However, it has never been reported in children. We describe a case of MT for refractory CVST in a child with NS. A 13-year-old boy with newly diagnosed NS presented to an emergency department with acute headache. A head computed tomography showed acute thrombus in the superior sagittal sinus, straight sinus and transverse sinus. The child was started on heparin therapy, but clinically deteriorated and became unresponsive. In view of the rapid deterioration of the condition after anticoagulation treatment, the patient received intravascular treatment. Several endovascular technologies, such as stent retriever and large bore suction catheter have been adopted. After endovascular treatment, the patient’s neurological condition was improved within 24 hours, and magnetic resonance venography of the head demonstrated that the CVST was reduced. The child recovered with normal neurological function at discharge. This case highlights the importance of considering MT for refractory CVST, and we suggest that MT may be considered for refractory CVST with NS in children.
Analisis Pengaruh Kualitas Layanan Terhadap Kepuasan Konsumen Pada Kapal Mentawai Fast Rute Padang-Kepulauan Mentawai
Authors:   Universitas Katolik Widya Mandala Surabaya Indonesia, Oktaria Yudit , Mulyono Julius ,   Universitas Katolik Widya Mandala Surabaya Indonesia, Hartanti Lusia Permata Sari ,   Universitas Katolik Widya Mandala Surabaya Indonesia
Published: March 2023

Penelitian ini bertujuan untuk menganalisis variabel kualitas layanan serta pengaruhnya terhadap kepuasan konsumen. Melalui penelitian ini, penulis dapat mengetahui besar pengaruh yang terjadi terhadap kepuasan konsumen dan mengetahui penilaian konsumen terhadap kualitas layanan kapal Mentawai Fast. Menggunakan teknik pengambilan sampel yaitu purposive sampling, dimana sampel yang akan digunakan adalah orang yang pernah menggunakan kapal Mentawai Fast dalam jangka waktu 1 tahun terakhir. Metode analisis penelitian menggunakan validitas dan reliabilitas, normalitas, multikolinearitas, heteroskedastisitas, dan regresi linier berganda. Hasil penelitian menunjukkan faktor kualitas layanan berdasarkan tangible, reliability dan empathy memiliki pengaruh terhadap kepuasan konsumen. Sedangkan faktor kualitas layanan berdasarkan variabel responsiveness dan assurance tidak berpengaruh terhadap kepuasan konsumen.
Degradasi Sianida Dalam Limbah Cair Menggunakan Oksidator NaOCL
Authors:   Widya Mandala Catholic University - Engineering Faculty Indonesia, Anggorowati Adriana Anteng , Lourentius Suratno ,   Widya Mandala Catholic University - Engineering Faculty Indonesia
Published: March 2023

Sianida merupakan senyawa yang sangat bersifat toksik jika melebihi nilai ambang batas yang diijinkan oleh Pemerintah. Sianida dipergunakan pada proses sianidasi khususnya pada proses pengolahan bijih emas di bidang pertambangan. Sianidasi dilakukan oleh para penambang emas yang berskala kecil sebagai pengganti proses amalgamasi. Limbah cair dari proses sianidasi mengandung kadar sianida yang tinggi hingga 35 – 45 mg/L. Oleh sebab itu konsentrasi sianida yang masih tinggi ini perlu diturunkan supaya memenuhi syarat baku mutu sebelum dibuang ke lingkungan. Salah satu metode yang dapat digunakan untuk mendegradasi sianida dalam limbah adalah oksidasi. Oksidator yang dipergunakan dalam penelitian ini adalah NaOCl. Proses oksidasi dalam degradasi sianida ini dilakukan dengan variasi konsentrasi oksidator (% v/v) mulai dari 0,4%, 0,8%, 1,2%, 1,6% dan 2% dan variasi waktu oksidasi 0,5 jam, 1 jam, 1,5 jam, dan 2 jam. Proses oksidasi menggunakan NaOCl berlangsung 2 tahap, yaitu pembentukan senyawa sianat kemudian hidrolisis sianat yang menghasilkan gas nitrogen dan bikarkonat yang tidak toksik. Setiap proses oksidasi, pH selalu dijaga 12, sebab jika keasaman larutan tinggi dikhawatirkan akan menghasilkan senyara sianogen khlorida yang bersifat toksik. Berdasarkan hasil penelitian, limbah cair proses sianidasi yang mengalami pengenceran 15 kali, sehingga memiliki konsentrasi sianida 2,8740 mg/L dapat turun konsentrasinya menjadi 0,1095 mg/L dengan menggunakan oksidator NaOCl sebesar 2% (v/v) selama waktu oksidasi 2 jam. Konsentrasi sianida ini hampir mendekati baku mutu yang diijinkan dalam Permenkes No. 32 Tahun 2017 yaitu 0,
Studies of Solutions of Singularly Perturbed Ordinary Differential Equations
Authors: Akmatov A.
Published: March 2023

The eigenvalues of the Jordan matrix determine different types of stability. It is not always possible to obtain asymptotic estimates in the real axis. Therefore, in this paper we will consider the types of stability that can be estimated in the real axis. The problem under consideration is nonlinear, so it is possible to obtain an estimate for the delay of the loss of stability in the real domain. To calculate the integral, we apply the second theorem on the average in a certain integral. We prove the theorem as a result, we obtain an estimate of singularly perturbed ordinary differential equations.
Evaluation of Drought Resistance of Soft Wheat (Triticum aestivum L.) Genotypes in Field Conditions by Turgorometric Method
Authors: Huseynova E.
Published: March 2023

In the research work, 32 were local (materials of the “Cereals and Legumes” Department of the Institute of Genetic Resources of ANAS) and 25 were introduced by CIMMYT (International Center for Maize and Wheat Improvement), a total of 57 (Triticum aestivum L.) studied the effect of stress factors on physiological processes of autumn soft wheat genotypes under field conditions, especially drought on the water retention capacity of leaves. Water retention capacity is considered as a very valuable trait of wheat genotypes and is evaluated as resistance to drought stress. As a result of the study, among 57 wheat genotypes, the following genotypes were classified as I- drought resistant (Gobustan (st.) (AZE), Bol wheat (AZE), Grekum75/50 (AZE), Taraggi (AZE), Akinchi84 (AZE), Giymetli 2/ 17(AZE), Sheki 1(AZE), Tale38 (AZE),TX96V2847(US-TX), Arlin/Yuma (USA-KSU), MV Dalma (HU-MV), Desin (RO-FL), Duopebusa (MOL ), SG-S1915 (CZ), U1254-7-9-2-1/TX86A5616//Rina-6)(TCI), II- moderately resistant to drought (Arzu (AZE), Zardabi (AZE), Durdane (AZE), Mirbashir128 (AZE), Nurlu99 (AZE), Ruzi84 (AZE), Aran (AZE), Murov2(AZE), GobustanS2 (AZE), Starshina (RUS-KR), MV06-02 (HU-MV), Gerek (TR- ESK), Gloria (RO-FL), Bezostaya1(TR-ESK), LC924/Petja (BG-SAD), Sonmez (TR-ESK), Dalnitskaya (UKR)) and III- drought (Birlik (AZE), Gurgane 1 (AZE), Karabakh10 (AZE), Parzivan 1(AZE), Parzivan 2(AZE), Azeri (AZE), Saba (AZE), Zubkov (KYR), Steklovidnaya 24 (KAZ)) are grouped as sensitive.
Effect of Hawthorn as a Feed Additive on Milk Yield and Quality of Cow’s Milk
Authors: Abbasova T. , Dashdamirov K.
Published: March 2023

In the course of the study, the fruits of the Caucasian hawthorn (Crataegus caucasica K. Koch) were added to the feed of the Holstein Friesian and Caucasian Brown (including 5 heads) dairy cattle as a feed additive, where feeding was carried out over a period of one month (20.03.2022-20.04.2022) and there was an increase in the quantity and quality of milk every 10 days. So, in contrast to conventional feeding, when feeding with hawthorn fruits, a noticeable increase in the specific gravity of milk, fat and lactose in dry matter, as well as the amount of macro- and trace elements, was recorded. It was also determined that the increase in milk was about 12.5%.
Theoretical Aspects of Social Education of Children of Primary School Age in Educational Organizations
Authors: Sabyrova E.
Published: March 2023

This article discusses the concept of social education for primary school age. The article is devoted to understanding the role of school education in the context of changing the educational paradigm. The mechanisms of socialization in school life, the main possibilities of educational strategies, tasks, directions and risks of the activity of the modern school as an institution of socialization are considered.
Theoretical Foundations of Social Education of Schoolchildren
Authors: Sabyrova E.
Published: March 2023

The concept of social education of pedagogical culture is considered. The problem of social education is now particularly relevant. During the school period, important changes take place in the life of the child, namely, the acquisition of a new social status "schoolchild". This period is the most sensitive for the development of human social abilities. At school age, he acquires social experience, begins to learn the norms of communication and behavior. In conclusion, the author concludes that the essential meaning of socialization is the integration and autonomation of the individual into the system of social relations. But in the conditions of a family, social education is not implemented in full, in this case, an institution of additional education comes to the rescue.
From Paper Patterns to Patterns-on-Fabric: Home Sewing in Sweden, 1881–1981
Authors: Törnvall Gunilla
Published: March 2023

From the end of the nineteenth century and one hundred years onward, home sewing was an important part of many women’s duties, but it was also a pleasure, something that existed parallel with the emerging mass-produced ready-to-wear industry. The paper patterns used for home dressmaking were often sold and distributed through women’s magazines. These pattern sections were both a kind of reader service and a conscious strategy to capture the female target group. This article, based on an analysis of three Swedish magazines, is the first in-depth survey of patterns for home sewing of women’s clothes in Sweden. The study shows how the magazines adapted to changes in society with increasingly easier patterns and ready-cut fabric for their readers. By highlighting women making their clothes in the home, this article contributes to an often-neglected area of women’s memory and fashion history.
A study of
avian diversity in Durgapur Government College Campus, West Bengal, India
Authors: Adhurya Sagar , Gayen Debayan , Chakrabarty Moitreyee , Singha Roy Utpal
Published: March 2023

The present study was performed to investigate bird diversity at Durgapur Government College Campus, West Bengal, India from January 2013 to January 2020. The standard point count method and opportunistic sightings were used to make the checklist of the bird species. A total of 106 different bird species belonging to 47 families were recorded. Sylviidae was recorded as the most diverse family. Out of the 106 bird species, 23 were winter migrants, 4 were summer migrants, 1 was passage migrant, 1 was vagrant and the rest 77 were residents. Winter months supported the highest species richness while maximum bird density was recorded in the month of March. The global population trend chart of the observed bird species showed that most of the species belonged to the stable category (52 %, 55 species). Alexandrine Parakeet (Psittacula eupatria) belonged to the Near Threatened category of the IUCN Red List category among the recorded birds. The present study area is now facing various anthropogenic disturbances which are leading to the decline of the bird populations and need special attention. More extensive studies will surely enrich our knowledge of the avifauna of this area.
Identifikasi Gambar Cadas di Situs Gua Liang Kobori Kabupaten Muna
Authors: Rasyidu Muhammad , Syahrun Syahrun , Suseno Sandy
Published: March 2023

Muna merupakan wilayah yang banyak tersebar peninggalan arkeologi berupa gua. Gua Liang Kabori merupakan salah satu situs gambar cadas yang terdapat di kabupaten tersebut. Gua Liang Kabori terletak di Desa Liang Kabori, Kecamatan Lohia, Kabupaten Muna. Gua Liang Kobori memiliki variasi gambar cadas yang berbeda dengan situs lain di wilayah Sulawesi Tenggara. Oleh karena itu, penulis tertarik untuk melakukan penelitian disitus tersebut. Penelitian ini bertujuan untuk mengetahui bentuk dan variasi gambar cadas pada Situs Gua Liang Kabori. Metode yang digunakan dalam penelitian ini ialah pengumpulan data lapangan berupa perekaman gambar dengan cara reproduksi gambar dengan skala 1:1. Selain itu, pengelompokkan gambar menggunakan klasifikasi dan deskriptif untuk  mengetahui keragaman bentuk gambar cadas pada situs Gua Liang Kabori. Dari penelitian yang dilakukan penulis, diketahui bahwa terdapat 186 motif gambar yang tersebar pada 46 panil. Gambar-gambar tersebut memiliki bentuk yang bervariasi baik dari segi motif maupun cara penggambarannya. Adapun variasi gambar tersebut terdiri dari motif figuratif; manusia, binatang dan tumbuhan. Sedangkan motif non figuratif terbagi dua yaitu geometris dan abstrak.
PENGARUH ARSITEKTUR KOLONIAL PADA RUMAH ADAT KAMALI BAADIA, KELURAHAN BAADIA, KECAMATAN MURHUM KOTA BAUBAU
Authors: Siswardin Siswardin , Kadir Ishak , Salniwati Salniwati
Published: March 2023

The Kamali Baadia traditional house as the last palace of the Buton Sultanate, combines the traditional architectural concepts of Buton and Colonial architects, for this purpose the research aims to find out the architectural form, explain the colonial architectural forms that affect the architectural characteristics of the Kamali Baadia traditional house and to determine the significance of the influence of Colonial architecture on the architectural form of the Kamali Baadia traditional house.

This type of research is qualitative, primary and secondary data sources, literature studies, observations, interviews and documentation using morphological analysis, technology, style and significance analysis of component changes.

The architectural form of the Kamali Baadia traditional house is a stilt house with an L-shaped floor plan arranged two floors facing North. The Kamali Baadia traditional house is divided into three components, namely legs, body and roof. The influence of Dutch colonial architecture on the Kamali Baadia traditional house is the Indische Empire Style architectural style with a floor plan on the first floor, a shield roof, a two-leaf door inside motif and a two-leaf window as well as an internal motif. Significant analysis of the sign by the influence of Dutch colonial architecture Indische Empire Style architecture has not been significant.
TINGGALAN ARKEOLOGIS BENTENG LIWU WAWONO DI KECAMATAN MAWASANGKA KABUPATEN BUTON TENGAH PROVINSI SULAWESI TENGGARA
Authors: Rauf Watlada , Aslim Aslim , Salniwati Salniwati
Published: March 2023

Tujuan penelitian ini adalah untuk : (1) Menjelaskan Latarbelakangi Sejarah situs benteng Liwu Wawono di Kecamatan Mawasangka Kabupaten Buton Tengah. (2)Menjelaskan apa saja tinggalan Arkeologi di situs benteng Liwu Wawono (3) Menjelaskan FungsiBenteng Liwu Wawono Sebagai Pertahanan dan pemukimanKesultanan Buton di Mawasangka.Hasil penelitian ini menunjukkan bahwa : (1) Latar belakangipembangunan Benteng Liwu Wawono yaitu sebagai strategi pertahanan dan keamanan guna melindungi masyarakat dari gangguan serangan yang akan datang (musuh) yang bermukim di Benteng Liwu Wawono. (2) Tinggalan arekeologis yang ada di Benteng Liwu Wawono terdiri atas Makam Kuno, dan Baruga, liang kuno serta temuan-temuan lepas berupa pecahan kramik, moluska dan pecahan gerabah. (3) Fungsi Benteng Liwu Wawono adalah sebagai tempat pertahanan pada Kesultanan Buton di bagianBarat Benteng Keraton Buton guna melindungi dari gangguan serangan musuh yang akan datang. selanjutnya Benteng ini sekarang dijadikan sebagai tempat pemukiman dan perkebunan masyarakat setempat.
ICON KEBO IWA DALAM PERADABAN MASYARAKAT PADANGBULIA
Authors: Wahyu Rustiani Komang , Made Swastya Dharma Pradnyan I Gusti , Kadek Arni Suwedawati Gusti Ayu
Published: March 2023

Peradaban Manusia menyimpan beragam misteri dari peninggalan-peninggalan masa lampau. Situs berupa batu besar, patung, hingga sarkopagus mengandung jejak histori yang diwarisi masyarakat setempat. Seperti situs bersejarah yang ada di Desa Padangbulia. Eksistensi peninggalan tersebut terpelihara secara alamiah melalui mitos yang bersifat mistis. Salah satu situs dalam peradaban masyarakat Padangbulia yaitu peninggalan Kebo Iwa. Tokoh Kebo Iwa familiar menjadi Ikonik secara mistis sebagai proses pewarisan kelisanan dalam menjalani kehidupan bermasyarakat. Mengandung bermacam interpretasi makna berdasarkan paradigma semiotika visual. Proses visualisasi dikolaborasikan antara pengetahuan kedaerahan dengan teknologi sehingga merepresentasi nilai-nilai budaya yang terkandung di dalamnya seperti, karakterisasi tokoh Kebo Iwa yang terdapat dalam cerita kelisanan di beberapa situs purbakala tersebut merepresentasi tokoh yang memiliki karakter kuat secara lahir dan batin, pekerja keras, pengabdian tinggi kepada pemimpin serta nilai etika moral bermasyarakat. Masyarakat lebih mudah mengadopsi karakter kepahlawan sesuai semangat jiwa zaman di era kepemiminan Raja Bali Kuno. Semiotika visual mendeskripsikan konsep dasar salah seorang pakar semiotika terdahulu yaitu Charles Sanders Pierce, dengan memfokuskan pada relasi tipologi tanda antara Ikonisitas, Indeks dan Simbol, sehingga mampu menghasilkan sistem produksi tanda. Selain itu, dalam proses interpretasi tanda visual kemudian dikaji berdasarkan tiga fase analisis ideologi dari Tompson.
STRATEGI PERTAHANAN JEPANG BERDASARKAN TINGGALAN ARKEOLOGI DI KECAMATAN POLEANG SELATAN KABUPATEN BOMBANA PROVINSI SULAWESI TENGGARA
Authors: Naswir Naswir , Aswati Aswati , Salniwati Salniwati
Published: March 2023

Penelitian ini bertujuan untuk mengetahui apa fungsi setiap tinggalan Jepang dan bagaimana strategi pertahanan Jepang berdasarkan tinggalan arkeologi di Kecamatan Poleang Selatan Kabupaten Bombana Provinsi Sulawesi Tenggara. Penelitian ini menggunakan teori Arkeologi, medan pertempuran dan teori Arkeologi Ruang. Metode penelitian berupa kuantitatif sebagai teknik pengumpulan data berupa studi pustaka. Metode kualitatif metode yang dilakuakan dilapangan yaitu survei permukaan, perekaman data setiap tinggalan dan wawancara. Pengolahan dan Analisis data menggunakan analisis data sejarah, analisis morfologi dan analisis kontekstual. Hasil penelitian menunjukkan bahwa tinggalan arkeologi yang ditemukan di Kecamatan Poleang Selatan berjumlah 42 tinggalan yaitu Wales berumlah 1, Revetment berjumlah 38, Bunker berjumlah 1, dan terowongan buatan Jepang berjumlah 2. Pembangunan setiap tinggalan arkeologis Jepang tersebut menunjukan strategi Jepang dalam menghadapi dan menghalau serangan sekutu. Strategi yang di gunakan Jepang yaitu memabanguna dan menempatkan sarana militer Jepang di area penting dan strategis yaitu area bendara, jety (dermaga) dan jalan utama.
Response to intranasal Lactococcus lactis W136 probiotic supplementation in refractory CRS is associated with modulation of non-type 2 inflammation and epithelial regeneration
Authors: Al-Romaih Saud , Harati Oumkaltoum , Mfuna Leandra Endam , Filali-Mouhim Ali , Pelletier Audrey , Renteria Flores Axel , Desrosiers Martin
Published: March 2023

Justification

We have previously documented that in individuals with chronic rhinosinusitis (CRS) refractory to surgery, intranasal application of live Lactococcus lactis W136, a probiotic bacterium, improves sinus-specific symptoms, SNOT-22, and mucosal aspect on endoscopy, accompanied by a reduction in sinus pathogens and an increase in protective bacteria. The present work explores the molecular mechanisms underpinning these observations using transcriptomics of the sinus mucosa.

Method

Epithelial brushings collected prospectively as a sub-study of the L. lactis W136 clinical trial were used to probe epithelial responses to microbiome supplementation using a hypothesis-free bioinformatic analysis of gene expression analysis. Samples from twenty-four patients with CRS refractory to medical and surgical management were prospectively collected during a clinical trial assessing the effect of 14 days of BID nasal irrigation with 1.2 billion CFU of live L. lactis W136 probiotic bacteria (CRSwNP = 17, CRSsNP = 7). Endoscopically guided sinus brushings were collected as part of the initial study, with brushings performed immediately before and after treatment. Following RNA extraction, samples were assessed using the Illumina HumanHT-12 V4 BeadChip. Differential gene expression was calculated, and pathway enrichment analysis was performed to identify potentially implicated processes.

Results

Differentially identified transcripts and pathways were assessed for the overall population and the clinical phenotypes of CRSwNP and CRSsNP. Patterns of response to treatment were similar across all groups, implicating pathways for the regulation of immunity and epithelial cell regulation. These resemble the patterns of improvement observed following successful treatment with endoscopic sinus surgery or azithromycin.

Conclusion

Gene expression profiling following the application of live bacteria to the diseased sinus epithelium highlights the implication of multiple components of the inflammation-microbiome-epithelial barrier axis implicated in CRS. These effects appear to involve both epithelial restoration and modulation of innate and adaptive immunity, supporting the potential interest of targeting the sinus epithelium and the microbiome as potential CRS therapies.
Role of MHC class I pathways in Mycobacterium tuberculosis antigen presentation
Authors: Witt Karolina D.
Published: March 2023

MHC class I antigen processing is an underappreciated area of nonviral host–pathogen interactions, bridging both immunology and cell biology, where the pathogen’s natural life cycle involves little presence in the cytoplasm. The effective response to MHC-I foreign antigen presentation is not only cell death but also phenotypic changes in other cells and stimulation of the memory cells ready for the next antigen reoccurrence. This review looks at the MHC-I antigen processing pathway and potential alternative sources of the antigens, focusing on Mycobacterium tuberculosis (Mtb) as an intracellular pathogen that co-evolved with humans and developed an array of decoy strategies to survive in a hostile environment by manipulating host immunity to its own advantage. As that happens via the selective antigen presentation process, reinforcement of the effective antigen recognition on MHC-I molecules may stimulate subsets of effector cells that act earlier and more locally. Vaccines against tuberculosis (TB) could potentially eliminate this disease, yet their development has been slow, and success is limited in the context of this global disease’s spread. This review’s conclusions set out potential directions for MHC-I-focused approaches for the next generation of vaccines.
Prognostic value of summed motion score assessed by gated SPECT myocardial perfusion imaging in patients with dilated cardiomyopathy
Authors: Zhu Jun-Yan , Wang Xin-Chao , Huang Nan , Li Xiao-Qian , Cheng Yan , Wu Zhi-Fang , Li Yuan-Yuan , Wu Ping , Li Li , Wei Hua , Li Si-Jin , Cao Ji-Min
Published: March 2023

Background

The prognosis of patients with dilated cardiomyopathy (DCM) is poor and new indicators are urgently needed to predict lethal cardiac events. This study aimed to investigate the value of summed motion score (SMS) in predicting cardiac death of DCM patients using gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI).

Methods and results

Eighty-one patients with DCM who underwent 99mTc-MIBI gated SPECT MPI were retrospectively enrolled and were divided into cardiac death and survivor groups. The functional parameters of left ventricle including SMS were measured using quantitative gated SPECT software. During the follow-up period of 44 (25, 54) months, 14 (17.28%) cardiac deaths were observed. Compared with the survivor group, SMS was significantly higher in the cardiac death group. Multivariate cox regression analysis showed that SMS was an independent predictor for cardiac death (HR 1.34, 95% CI 1.02–1.77, P = 0.034). SMS also provided incremental prognostic value over other variables in the multivariate model as determined by likelihood ratio global chi-squared test. In the Kaplan-Meier survival analysis, the event-free survival rate was significantly lower in the high-SMS (HSMS) group than the low-SMS (LSMS) (log-rank P < 0.001). Furthermore, the area under curve (AUC) of SMS was larger than that of LVEF at the 12th month of follow-up (0.85 vs. 0.80, P = 0.045).

Conclusion

SMS is an independent predictor of cardiac death in DCM patients and provides incremental prognostic value. SMS might have higher predictive value than LVEF for early cardiac death.
Real-life and real-time hearing aid experiences: Insights from self-initiated ecological momentary assessments and natural language analysis
Authors: Vercammen Charlotte , Oosthuizen Ilze , Manchaiah Vinaya , Ratinaud Pierre , Launer Stefan , Swanepoel De Wet
Published: March 2023

Introduction

Smartphone technology can provide an effective means to bring real-life and (near-)real-time feedback from hearing aid wearers into the clinic. Ecological Momentary Assessment (EMA) encourages listeners to report on their experiences during or shortly after they take place in order to minimize recall bias, e.g., guided by surveys in a mobile application. Allowing listeners to describe experiences in their own words, further, ensures that answers are independent of predefined jargon or of how survey questions are formulated. Through these means, one can obtain ecologically valid sets of data, for instance during a hearing aid trial, which can support clinicians to assess the needs of their clients, provide directions for fine-tuning, and counselling. At a larger scale, such datasets would facilitate training of machine learning algorithms that could help hearing technology to anticipate user needs.

Methods

In this retrospective, exploratory analysis of a clinical data set, we performed a cluster analysis on 8,793 open-text statements, which were collected through self-initiated EMAs, provided by 2,301 hearing aid wearers as part of their hearing care. Our aim was to explore how listeners describe their daily life experiences with hearing technology in (near-)real-time, in their own words, by identifying emerging themes in the reports. We also explored whether identified themes correlated with the nature of the experiences, i.e., self-reported satisfaction ratings indicating a positive or negative experience.

Results

Results showed that close to 60% of listeners' reports related to speech intelligibility in challenging situations and sound quality dimensions, and tended to be valued as positive experiences. In comparison, close to 40% of reports related to hearing aid management, and tended to be valued as negative experiences.

Discussion

This first report of open-text statements, collected through self-initiated EMAs as part of clinical practice, shows that, while EMA can come with a participant burden, at least a subsample of motivated hearing aid wearers could use these novel tools to provide feedback to inform more responsive, personalized, and family-centered hearing care.
Pre-testing erroneous text-based documents: Logging end-user activities
Authors: Nagy Keve , Csernoch Mária
Published: March 2023

An extremely high number of erroneous text-based documents are in circulation, being multiplied, serving as samples both in the office world and in education. Creating, editing, and modifying these documents generates a serious financial loss when both human and machine resources are considered. Our research team developed an application and a testing method for building up an objective measurement system, in order to see the rate of loss in the handling of erroneous documents. In the pre-testing period, the error factor of a sample text was set up based on the logged activities of an expert researcher. It was found that first level modifications require about five times more human and machine resources in a short, one-paragraph text burdened with layout errors than in its properly formatted version. Further testing is required to find out how demanding longer texts and more serious modifications are, but it is already obvious that erroneous text-editing, and the lack of fundamental computational thinking skills involve unnecessary use of our resources.
Considerations for continued expansion of the Brazilian post-graduate system
Authors: McManus Concepta , Baeta Neves Abilio Afonso , Carvalho Carlos Henrique , Souza Filho Antonio Gomes , Freire Denise Maria Guimarães , Fioravanti Maria Clorinda Soares , Báo Sônia Nair , de Medeiros Isac Almeida , Diniz Filho José Alexandre , Diaz Bruno Lourenço , de Carvalho Ernani Rodrigues , Audy Jorge Luís Nicolas , Silva Filho Marcio de Castro , Gimenez Juliano Rodrigues , Carvalho Margarida , da Silva Robério Rodrigues , Napimoga Marcelo Henrique
Published: March 2023

The number of programs and students in the Brazilian postgraduate system has doubled in the last 10 years. This has implications for the quality and financing of these programs as well as for the development of the regions where they are set. This study aims to investigate the reasons and limitations for the continued expansion of the Brazilian postgraduate system. Data (2011 to 2020) for this study came from: (i) the “Sucupira” postgraduate database from the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), (ii) Instituto Nacional de Estudos e Pesquisas Educacionais Anísio Teixeira (INEP), (iii) Brazilian Institute of Geography and Statistics (IBGE), (iv) InCites® and Web of Science data, and (v) questionnaire and meetings with the deans for Higher Education Institutions (HEIs) in Brazil. Data analyses included regression over time, frequency chi-square, and correspondence analyses. Different types of institutions in different regions showed varying opinions, with higher expectations for expansion in smaller, newer institutions, especially private ones. While the HEIs in the Northern region believe that the master’s degree is to correct undergraduate flaws, the HEIs in the South and Central regions and the community believe that the master’s degree should develop professional skills. In contrast, the larger HEIs with older postgraduate programs in all regions believe in direct doctorate strategy. The reasons for creating new post-graduate programs involved following the institution’s general guidelines for private and community HEIs and granting the lecturers’ wishes or constant expansion depending on region, North, Northeast, and Central regions, as well as for creating medium-sized state universities. State-of-the-art research or the interests of society were prevalent for the largest and oldest HEIs. Continued expansion of the Brazilian postgraduate system needs to take into account factors including the demand for the program, regionalization, the quality of the programs, the means of funding, and the student vacancies existing in programs with high grades, among other challenges.
Cortisol and periodontitis: Prospective observational and Mendelian randomization studies
Authors: Baumeister Sebastian-Edgar , Reckelkamm Stefan Lars , Grabe Hans-Jörgen , Nauck Matthias , Klinger-König Johanna , Völzke Henry , Kocher Thomas , Friedrich Nele , Holtfreter Birte
Published: March 2023

Purpose

Cortisol has obesogenic, hyperglycemic and immunomodulating effects. Preclinical and observational research suggested that it is associated with periodontitis but the evidence for potential causality in humans is sparse. We triangulated results from prospective observational and Mendelian randomization (MR) analyses to further explore this.

Methods

Using pooled data from 3,388 participants of two population cohort studies embedded in the Study of Health in Pomerania (SHIP) project, we associated serum cortisol levels with periodontal outcomes measured after a median follow-up time of 6.9 years, adjusting for confounding and selection bias using propensity score weighting and multiple imputation. We further examined the effect of genetically proxied plasma morning cortisol levels on periodontitis using two-sample MR of 17,353 cases and 28,210 controls.

Results

In SHIP, we found that cortisol levels were positively associated with follow-up levels of mean clinical attachment level (CAL), deep interdental CAL and bleeding on probing but were unrelated to mean probing pocket depth and deep periodontal pockets. In MR analysis, cortisol was not associated with periodontitis.

Conclusion

The observational study revealed a prospective association of spot cortisol with makers of periodontitis. Contrary to observational studies, genetically instrumented, long-term cortisol was unrelated to periodontitis. Our results find no univocal evidence that cortisol plays a role in periodontitis pathology, casting doubt on cortisol-related pathways.
Clinical correlates and metabolic indicators of elevated fasting glucose in overweight/obese Chinese Han patients with first-episode and drug-naive major depressive disorder
Authors: Gao Wenqi , Deng Zhifang , Cai Xiaonan , Zhang Dan , Xiao Han , Zhang Xiangyang
Published: March 2023

Background

Overweight/obese major depressive disorder (MDD) patients have a high probability of developing glucose metabolism disorders; however, the results are inconsistent due to the confounding variables involved in the studies. The purpose of this study was to explore the prevalence and risk factors for elevated fasting glucose in Chinese Han patients with overweight/obese first-episode and drug naïve (FEDN) MDD.

Methods

The study used a cross-sectional design and recruited 1718 FEDN MDD patients between the ages of 18 and 60 years. Socio-demographic information, anthropometric data, and biochemical parameters were collected. The 17-item Hamilton Assessment Scale for Depression (HAMD), the 14-item Hamilton Anxiety Scale (HAMA), and the Positive and Negative Syndrome Scale (PANSS) positive subscale were used to assess symptoms of all patients.

Results

MDD patients with elevated fasting glucose had higher TSH, TPOAb, TC, TG, LDL-C, systolic and diastolic blood pressure levels than those with normal fasting glucose. Logistic regression analysis showed that age, TSH, TgAb, TPOA, and TG were related factors for elevated fasting glucose, while TSH and combination all these five parameters had the potential to differentiate between patients with elevated fasting glucose and those with normal fasting glucose. Multifactorial regression analysis showed that TSH, TG, and LDL-C were independently associated with elevated fasting glucose.

Conclusion

Our findings suggest a high prevalence of elevated fasting glucose in overweight/obese FEDN MDD patients. Several clinically relevant factors and metabolic parameters are associated with elevated fasting glucose in overweight/obese FEDN MDD patients.

Limitation

Due to the cross-sectional design, no causal relationship could be derived.
Bioinformatic analysis confirms differences in circular RNA expression profiles of cumulus cells between patients with ovarian and peritoneal endometriosis-associated infertility
Authors: Huang Xiaodi , Yu Qi
Published: March 2023

Endometriosis has a detrimental effect on oocyte quality, and ovarian endometriosis (OEM) and peritoneal endometriosis (PEM) may have different effects on female fertility. Therefore, we conducted a study to explore the circular RNA (circRNA) expression profiles of cumulus cells (CCs) in patients with OEM (n = 3), PEM (n = 3), and tubal factor infertility (TFI, n = 3) using high-throughput sequencing techniques and attempted to identify common and unique circRNAs in the OEM and PEM groups. The CIRCexplorer2 program was used to identify circRNAs. Seven candidate circRNAs were validated in 30 samples using quantitative real-time polymerase chain reaction (qRT-PCR). Finally, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were performed to annotate the function of circRNA-targeted genes, which were verified by sequencing results and constructed circRNA–miRNA–mRNA networks. A total of 11833 circRNAs were identified in nine samples. The numbers of differentially expressed circRNAs between the OEM and TFI groups, PEM and TFI groups, and OEM and PEM groups were 130, 71, and 191, respectively. After taking intersections, 11 circRNAs were considered common circRNAs in the OEM and PEM groups; 39 circRNAs in the OEM group and 17 circRNAs in the PEM group were identified as unique key circRNAs. During qRT-PCR validation, hsa_circ_0003638 was significantly upregulated in the PEM group compared to that in the OEM and TFI groups. Functional analysis of circRNA-targeted genes revealed that apoptosis, PI3K-AKT, and p53 signaling pathways were enriched in the PEM–TFI comparison groups, whereas the functions of target genes involved in the JAK–STAT and TGF-β signaling pathways were enriched in the PEM–OEM comparison groups. Our findings confirmed differences in circRNA expression profiles of CCs between patients with OEM and PEM infertility and provide new insights into the different effects of various endometriosis phenotypes on oocytes.