bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the joint of superconducting tapes for railway feeder cable
Authors: Akasaka T , Ishihara A , Onji T , Yamamoto H , Tomita M , Zhong Y , Otabe E S
Published: August 2022

Developing superconducting cable for railway power transmission should lead to increased regeneration efficiency, reduced power loss, equalization of load between substations. In order to realize a kilometer-class superconducting feeder cable, on-site joint technique between superconducting feeder cables is required. For joining superconducting cables at railway construction sites, we conducted solder joining of superconducting tapes and its evaluation in the laboratory. We performed electromagnetic analysis of the joints by the finite element method in order to obtain a prospect of the optimum conditions of the solder joining. The target value of the joint resistance to 10−7 Ω class will be achieved by the solder joining regardless of the solder thickness and the joint length. Referring to the analysis results, mechanical and electrical properties measurement of the joined superconducting tape was conducted. From the results of the tensile and bending test, it is found that the solder joined superconducting tape with the lap length of more than 20 mm achieve the mechanical and electrical targets. These results are being utilized for cable joining at railway construction sites.
Operation of a 4-bit RSFQ digital-to-analog converter based on a binary split-confluence configuration
Authors: Sega Naonori , Somei Yuta , Shimada Hiroshi , Mizugaki Yoshinao
Published: August 2022

One of the unique applications of single-flux-quantum (SFQ) circuitry is a digital-to-analog converter (DAC) of which the output voltage is defined by the Josephson effect. Recently, we have designed and operated rapid single-flux-quantum (RSFQ) DACs with frequency modulation of SFQ pulse sequences. In this paper, we report our design and test results of a 4-bit RSFQ-DAC based on the configuration of the “sum of selected bits sequence (Σ-SBS)”. By adjusting the timing margins, in addition to the fabrication using the Nb integration process with the critical current density as high as 10 kA/cm2, the maximum output voltage up to 260 μV was demonstrated.
Modelling the impact of radiation damage effects in in-flight and on-ground irradiated Gaia CCDs
Authors: Ahmed S. , Hall D.J. , Skottfelt J.M. , Dryer B. , Holland A. , Crowley C. , Hernandez J.
Published: August 2022

The European Space Agency’s Gaia spacecraft was launched in 2013 and has been in operation ever since. It has a focal plane of 106 Charge-Coupled Devices (CCDs) which are of the CCD91-72 variant, custom designed by Teledyne e2v. The detectors have been making measurements of parallaxes, positions, velocities, and other physical properties of over one billion stars and other astronomical objects in the Milky Way. Whilst operating in space, CCDs undergo non-ionizing displacement damage from incoming radiation. This causes radiation induced trap defects to form in the silicon lattice which can trap electrons during readout and increase the charge transfer inefficiency (CTI) of the devices significantly. From analysis of in-flight charge calibration data, Gaia’s CTI values have been measured to be lower than what was expected based on the on-ground pre-flight tests. In this study, the CTI and trap landscape in both in-flight and irradiated on-ground devices are modelled to fit the new datasets. This was done thanks to the help of a detector simulation toolkit called Pyxel which implemented a version of a CTI model developed for Gaia called the Charge Distortion Model (CDM). These results provide more insights into the nature of radiation damage and the resulting trap landscapes, both in space and from on-ground irradiations.
A biomimetic three-layered fibrin gel/PLLA nanofibers composite as a potential scaffold for articular cartilage tissue engineering application
Authors: Riazi Moghadam Roozbeh , Keshvari Hamid , Imani Rana , Nazarpak Masoumeh Haghbin
Published: August 2022

Developing an engineered scaffold inspired by structural features of healthy articular cartilage (AC) has attracted much attention. In this study, the design and fabrication of a three-layered fiber/hydrogel scaffold in which each layer replicates the organization of a pertinent layer of AC tissue is aimed. To this end, electrospun poly-L-lactic acid (PLLA) nanofibers are prepared and fragmented into nano/micro cylinders via aminolysis. Three-layers of the scaffold, a fibrin coated fibrous layer, a fibrin gel (FG) layer incorporating chopped fibers and a FG embedding cylindrical aligned fibrous mat perpendicular to articulating surface, respectively served as an upper, middle and bottom layers, are prepared. The layers’ physicomechanical characteristics are comprehensively evaluated. Results show that optimized electrospinning set up results in the smallest fibers diameter of 367 ± 317 nm and successful aminolysis provides amine-functionalized chopped nanofibers with a mean length of 1.46 ± 0.9 µm. Static mechanical analysis of the layers demonstrates that tensile Young’s modulus of the upper layer is 152 ± 17 MPa while compressive moduli of the middle and bottom layers are 9.8 ± 3.8 and 25.3 ± 5.2 KPa, respectively and the compressive modulus of three-layered scaffold is 13.7 ± 2.5 KPa. Assessing mechanical parameters under dynamic loading also shows that adding fibrous part in the composite scaffold layers enhances viscoelastic behavior of FG. Also, incorporation of 0.25% chopped fibers into the fibrin matrix notably enhances the equilibrium water content; however, it increases in-vitro weigh loss rate from 6% to 10.5% during a seven-day period. Cytocompatibility analysis confirms that all layers possess acceptable cytocompatibility. In a conclusion, the designed three-layered composite structure successfully mimics the physicomechanical as well as microstructural features of AC and could be suggested as a potential scaffold for this tissue regeneration.
Preparation of α-MoO3 from H3PMo12O40 precursor: synthesis of 1,2-cyclohexanediol from cyclohexene over α-MoO3-TiO2 catalyst
Authors: AlGarni Tahani Saad , Abduh Naaser A Y , Kahtani Abdullah Al , Aouissi Ahmed
Published: August 2022

A series of α-MoO3-TiO2 mixed oxides were prepared by calcining a mixture of the heteropolyacid H3PMo12O40 and TiO2 at temperatures ranging from 350 °C to 600 °C. The mixed oxides thus prepared were characterized and tested for the oxidation of cyclohexene by the oxidizing mixture H2O2/CO2. FTIR and XRD characterizations showed that the Keggin structure of H3PMo12O40 was preserved for calcination temperatures below 400 °C. Above 450 °C, Keggin’s structure collapses. XRD analysis revealed that as the calcination temperature increased, more orthorhombic α-MoO3 was formed. Analysis of the reaction mixture by GC-MS showed that oxidation by the H2O2/CO2 mixture leads to 1,2-cyclohexanediol as the main product and to 2-cyclohexene-1-one and 2-cyclohexene-1-ol as minor products. Oxidation by H2O2/CO2 mixture proved to be more effective than H2O2 alone and CO2 alone. The conversion (69.4%) and the 1,2-cyclohexanediol selectivity (93.2%) obtained over α-MoO3-TiO2 mixed oxides, higher than that obtained with TiO2 monoxide and α-MoO3 monoxide, suggest a synergistic effect between TiO2 and α-MoO3. This efficient and stable catalyst after reuse can be developed for the synthesis of diols.
Frailty: understanding the difference between age and ageing
Authors: Gordon Emily H , Hubbard Ruth E
Published: August 2022

In the past, illness and dependence were viewed as inevitable consequences of old age. Now, we understand that there is a difference between age (the passing of chronological time) and ageing (the increased risk of adverse outcomes over time). Over the last 50 years, ‘frailty’ research has established that ageing is heterogeneous, variable and malleable. Significant advances have been made in frailty measurement (description of clinical features and development of clinical models), mechanisms (insights into pathogenesis) and management (development of interventions to reduce and/or prevent progression). Subsequently, the concept of frailty has informed health policy and clinical practice and started to change perceptions of older age held by the general public and the health sector. Here, we overview key achievements in frailty research and clinical practice and highlight the considerable number of known unknowns that may be addressed in the future.
Introducing stimulogenetics, unraveling pertinent semantic ambiguity, and determining clinical relevance among novel neuromodulation strategies
Authors: Garg Pranjal , Muthiah Saidharshini , Sengupta Sumedha
Published: August 2022

Deep brain stimulation involving the stereotactic implantation of electrodes in the deeper neural tissue remains one of the most trusted nonpharmacotherapeutic approaches for neuromodulation in the clinical setting. The recent advent of techniques that can modulate the neural structure and/or function at the cellular level has stimulated the exploration of these strategies in managing neurological and psychiatric disorders. Optogenetics, which is widely employed in experimental research, is the prototype of the above techniques. Other methods such as chemogenetics, sonogenetics, and magnetogenetics have also been introduced. Although these strategies possess several noticeable differences, they have an overlapping conceptual framework enabling their classification under a singular hypernym. This article introduces this hypernym, “stimulogenetics” in an attempt to solve the pertinent ambiguity to aid the classification of existing literature. The article also compares the strategies classified under stimulogenetics and concludes that the current literature suggests that nonsurgical approaches such as chemogenetics and sonogenetics are better suited for clinical applications. However, due to the dearth of clinical studies, it is not possible to determine this definitively.
Randomized clinical trials comparing antibiotic therapy with appendicectomy for uncomplicated acute appendicitis: meta-analysis
Authors: Herrod Philip J J , Kwok Alex T , Lobo Dileep N
Published: August 2022

Background

This aim of this study was to provide an updated meta-analysis comparing antibiotic therapy with appendicectomy in adults (16 years or older) with uncomplicated acute appendicitis.

Methods

A search for randomized clinical trials comparing antibiotic therapy with appendicectomy in adults with uncomplicated acute appendicitis from inception to 3 October 2021 in MEDLINE, Embase and CENTRAL with no language constraints was performed. Studies were excluded if they included paediatric participants or those with complicated appendicitis. Data on complications of treatment, treatment efficacy (defined in the antibiotic group as not undergoing appendicectomy within 1 year of enrolment, versus surgery without complications or no negative histology in the appendicectomy group), readmissions, and length of stay (LOS) were presented.

Results

Eight RCTs involving 3203 participants (1613 antibiotics/1590 appendicectomy; 2041 males/1162 females) were included. There was no significant benefit of antibiotic treatment on complication rates (risk ratio (RR) 0.66, 95 per cent c.i. 0.41 to 1.04). Antibiotics had a reduced treatment efficacy compared with appendicectomy (RR 0.75, 95 per cent c.i. 0.63 to 0.89). Antibiotic treatment at 1 year was successful in 1016 of 1613 (62.9 per cent) participants. There was a six-fold increase in hospital readmissions within 1 year of enrolment in participants receiving antibiotic treatment (RR 6.28, 95 per cent c.i. 2.87 to 13.74). There was no difference in index admission LOS (mean difference 0.15 days (95 per cent c.i. −0.05 to 0.35)).

Conclusions

Earlier optimism regarding the benefits of antibiotic therapy for uncomplicated acute appendicitis does not persist at the same level now that further, large trials have been included. If antibiotic treatment is to be offered routinely as first-line therapy, patients should be counselled appropriately.
Workplace exposure to UV radiation and strategies to minimize cancer risk
Authors: Cherrie J W , Cherrie M P C
Published: August 2022

Background

Workplace exposure to solar ultraviolet (UV) causes malignant melanoma and non-melanoma skin cancer. The evidence for beneficial effects of solar UV exposure in reducing the risks for other cancers is increasing. The intensity of UV radiation at the Earth’s surface is dependent on latitude, but even in northern European countries exposure can be high enough for outdoor work to cause skin cancer.

Growing points

Awareness of the health risks and benefits of occupational solar UV exposure is poor. Actions to reduce the risk of skin cancer have been identified and employers should recognize their responsibility to actively manage these risks. There is evidence for reduced risks for breast, ovarian and colorectal cancer and possibly other cancers linked to solar UV exposure.

Sources of data

This narrative review draws on published scientific articles and material designed to assist identifying strategies to protect workers from solar UV exposure.

Areas of agreement

Solar UV exposure can be harmful. Wavelengths in the UVB range are more effective in causing erythema and DNA damage. Solar UV is the main source of vitamin D for most people. Primary and secondary prevention for skin cancer can potentially eliminate these risks but the evidence for effectiveness is limited.

Areas of controversy

Potential health benefits of UV exposure, particularly for reduced cancer risk. Determining and communicating optimal exposure to maximize health benefits. The risk of non-melanoma skin cancers may be more than doubled for some workers in temperate latitudes.

Areas timely for developing research

Exposure-response epidemiological studies; studies of the health benefits of occupational UV exposure; studies of the effectiveness of intervention strategies to prevent skin cancer. Use of low-cost UV sensors in workplaces.
Neurophysiological evidence for goal-oriented modulation of speech perception
Authors: Chai Xiaoke , Liu Min , Huang Ting , Wu Meiyun , Li Jinhong , Zhao Xue , Yan Tingting , Song Yan , Zhang Yu-Xuan
Published: August 2022

Speech perception depends on the dynamic interplay of bottom-up and top-down information along a hierarchically organized cortical network. Here, we test, for the first time in the human brain, whether neural processing of attended speech is dynamically modulated by task demand using a context-free discrimination paradigm. Electroencephalographic signals were recorded during 3 parallel experiments that differed only in the phonological feature of discrimination (word, vowel, and lexical tone, respectively). The event-related potentials (ERPs) revealed the task modulation of speech processing at approximately 200 ms (P2) after stimulus onset, probably influencing what phonological information to retain in memory. For the phonological comparison of sequential words, task modulation occurred later at approximately 300 ms (N3 and P3), reflecting the engagement of task-specific cognitive processes. The ERP results were consistent with the changes in delta-theta neural oscillations, suggesting the involvement of cortical tracking of speech envelopes. The study thus provides neurophysiological evidence for goal-oriented modulation of attended speech and calls for speech perception models incorporating limited memory capacity and goal-oriented optimization mechanisms.
A case series of desmoplakin cardiomyopathy: a mimic of viral myocarditis
Authors: Rezaei Bookani Kaveh , Minga Iva , Wodskow Joshua , Harris Jordan , Gordon Robert , Sarswat Nitasha , Pursnani Amit
Published: August 2022

Background

Clinical features and imaging presentation of myocarditis can overlap with other inflammatory or arrhythmogenic cardiomyopathies. Desmoplakin (DSP) is an important structural cardiac protein. Mutations in the DSP gene are associated with a variant of arrhythmogenic right ventricular cardiomyopathy (ARVC). Interestingly, this distinct genetic cardiomyopathy can also present with a myocardial inflammation and fibrosis pattern that may mimic other forms of myocarditis including viral myocarditis, which can raise a clinical challenge. We report two cases of DSP cardiomyopathy, which were initially thought to represent coronavirus disease of 2019 (COVID-19) myocarditis.

Case summary

First patient is a 21-your-old woman with no past medical history but family history of presumed ‘viral myocarditis’ and ventricular tachycardia in her brother. She presented with acute chest pain and elevated cardiac enzymes. She tested positive for COVID-19 and given the suspicion for possible COVID-19 related acute myocarditis, cardiac magnetic resonance imaging obtained and revealed regional wall motion abnormalities, several areas of subepicardial and pericardial late gadolinium enhancement (LGE). Ambulatory cardiac monitoring showed runs of non-sustained ventricular tachycardia and considering her family history of arrhythmogenic myocarditis, genetic testing was performed that was positive for a likely pathogenic heterozygous mutation of DSP gene. She declined the recommended implantable cardioverter defibrillator (ICD).

Second patient is a 34-year-old physician with no significant past medical history who works at a COVID-19 unit and presented with syncope and was found to have ventricular tachycardia. Echocardiogram revealed severely dilated left ventricle and globally depressed systolic function with left ventricular ejection fraction of 20%. Coronary computed tomography angiography showed no evidence of coronary atherosclerosis. Cardiac magnetic resonance imaging revealed several areas of mid myocardial and pericardial LGE. Subcutaneous ICD was implanted and an endomyocardial biopsy had evidence of lymphocytic myocarditis and adipose tissue infiltration of the myocardium. Genetic testing revealed pathogenic heterozygous DSP mutation. He underwent epicardial ablation for the episodes of ventricular tachycardia despite medical therapy. He was able to return to work and has not had any further episodes of arrhythmia.

Conclusion

Mutations in the DSP gene are associated with left dominant arrhythmogenic cardiomyopathy, which is a variant of ARVC. Beside left ventricular systolic dysfunction and ventricular tachyarrhythmias, carriers of these mutations may present with episodes of chest pain associated with elevated cardiac enzymes and cardiac imaging findings indistinguishable from other forms of acute myocarditis including viral myocarditis. Currently, there are no guidelines for diagnosis and treatment of this entity.
Demystifying non-coding GWAS variants: an overview of computational tools and methods
Authors: Schipper Marijn , Posthuma Danielle
Published: August 2022

Genome-wide association studies (GWAS) have found the majority of disease-associated variants to be non-coding. Major efforts into the charting of the non-coding regulatory landscapes have allowed for the development of tools and methods which aim to aid in the identification of causal variants and their mechanism of action. In this review, we give an overview of current tools and methods for the analysis of non-coding GWAS variants in disease. We provide a workflow that allows for the accumulation of in silico evidence to generate novel hypotheses on mechanisms underlying disease and prioritize targets for follow-up study using non-coding GWAS variants. Lastly, we discuss the need for comprehensive benchmarks and novel tools for the analysis of non-coding variants.
Planning and scheduling of a parallel-machine production system subject to disruptions and physical distancing
Authors: Bazargan-Lari Mohammad Reza , Taghipour Sharareh , Zaretalab Arash , Sharifi Mani
Published: August 2022

This paper aims to quantify the effects of production disruptions (PDs) and physical distancing constraints due to the pandemic in a parallel-machine production environment. The machines are non-identical and are utilized for producing a finite set of jobs (parts) in a plastic injection moulding production. The production process is subjected to random production downtime disruptions. A mixed-integer linear programming (MILP) model is developed for optimizing the joint production plan and schedule, which maximizes the production’s total benefit. The model is utilized to plan and schedule a set of 17 machines in a Canadian manufacturing company. To explore the effects of physical distancing and PDs on the production’s total net profit, four different scenarios for normal operation and production during the pandemic, with and without production downtimes, are considered. A genetic algorithm is utilized to solve the model. The results show that considering machines’ random breakdowns and physical distancing individually reduces the total profit of the production by 71.58 and 57.98%, respectively; while their joint effect results in a 88.54% reduction in the annual net profit.
Clonal dissemination of carbapenem-resistant Klebsiella pneumoniae ST16 co-producing NDM-1 and OXA-232 in Thailand
Authors: Abe Ryuichiro , Akeda Yukihiro , Takeuchi Dan , Sakamoto Noriko , Sugawara Yo , Yamamoto Norihisa , Kerdsin Anusak , Matsumoto Yuki , Motooka Daisuke , Leolerd Warawut , Santanirand Pitak , Suzuki Masato , Shibayama Keigo , Tomono Kazunori , Iida Tetsuya , Hamada Shigeyuki
Published: August 2022

Background

Klebsiella pneumoniae ST258 and ST11 carrying blaKPC are among the most widespread carbapenem-resistant K. pneumoniae strains worldwide. Our carbapenem-resistant Enterobacteriaceae surveillance in Thailand revealed a nationwide dissemination of K. pneumoniae ST16 isolates carrying blaNDM-1 and blaOXA-232.

Objectives

To analyse the genomic details of this nationwide dissemination by focusing on plasmids and virulence factors.

Methods

Using WGS data of 119 K. pneumoniae ST16 isolates carrying blaNDM-1 obtained in our previous surveillance study, clonality of chromosomes and plasmids of the isolates with carriage of virulence factors was evaluated.

Results

Of the 119 isolates, 111 carried plasmid pKP151_NDM1, and all 104 isolates harbouring blaOXA-232 carried plasmid pKP151_OXA232. These 104 K. pneumoniae ST16 isolates showing chromosomal clonality possessed both pKP151_NDM1 and pKP151_OXA232, demonstrating clonal dissemination of K. pneumoniae ST16 with these plasmids. The isolates had essentially similar virulence factors as those of K. pneumoniae ST16 clones carrying blaKPC, which were recently reported as highly invasive clones in Brazil.

Conclusions

The potential global dissemination of these invasive clones with resistance to several antibiotics highlights the importance of appropriate monitoring and strict standard precautions.
Ovarian development of the crabEriphia gonagra(Fabricius, 1781) (Decapoda: Brachyura: Eriphiidae) in northeastern Brazil
Authors: Rios Aline S , Shinozaki-Mendes Renata A , Santana Julianna L , Souza-Filho Jesser F
Published: August 2022

We describe the development and maturation of the germ cells of the brachyuran crab Eriphia gonagra (Fabricius, 1781). Monthly collections were conducted in Pernambuco state, northeastern Brazil, from November 2018 to October 2019 during the low spring tide. The anatomy of the reproductive system of female individuals follows the basic brachyuran pattern. Five cell developmental stages were identified based on the morphological changes in the developmental stages: oogonia (7.10 ± 1.85 µm), pre-vitellogenic oocytes (42.23 ± 8.61 µm), oocytes in initial vitellogenesis (130.49 ± 21.93 µm), vitellogenic oocytes (139.68 ± 23.45 µm), and mature oocytes (214.77 ± 90.81 µm). Developmental stages were defined and related to gonad coloration and germ- cell development; five maturational stages were identified: immature, initial maturation, advanced maturation, mature, and spawning/resting.
MiFID II and the Regulation of Multilateral Trading in OTC Derivatives: Is the OTF Fit for Purpose?
Authors: Helm Simon
Published: August 2022

This article identifies barriers to the complete implementation of the organized trading facility (OTF) as a new category of trading venue under the Markets in Financial Instruments Directive (Directive 2014/65/EU) (MiFID II). It argues that attempts to reconcile the competing claims of incumbent regulated markets and dealer banks operating broker crossing networks in the cash securities markets led to a market design that is not suitable for the over-the-counter (OTC) derivatives markets. The result has been that multilateral trading in the wholesale secondary markets has not been incorporated in trading venues, as was intended, and that changes that are better aligned to market requirements are needed. These include reform of requirements transposed from the cash securities markets, such as standardized fee structures, and relaxation of restrictions on interactions between an OTF and other OTFs or systematic internalizers.
The elusive triple win: addressing temporary labour migration dilemmas through fair representation
Authors: Bauböck Rainer , Ruhs Martin
Published: August 2022

Temporary Labour Migration Programmes (TLMPs) are controversial because they are caught in a dilemma between global and domestic justice. From a global justice perspective, TLMPs expand opportunities for workers in poor countries to access labour markets of rich countries and they improve the situation of origin countries through remittances. From a domestic justice perspective, TLMPs violate principles of domestic equality because they always afford migrant workers more restricted rights than those enjoyed by citizens and long-term residents of the host country. Although this dilemma cannot be fully resolved, we argue that TLMPs can be morally justified and recommended if they are characterised by ‘fair representation’ in policy design and implementation and also meet certain democratic legitimacy conditions. TLMPs can be justified if they provide triple benefits for destination and origin countries as well as for migrants themselves, yet the relevant benefits can only be achieved cooperatively through transnational governance in which each of the three groups of actors is fairly represented. This conclusion is supported by our interpretation of the democratic principle of including all affected interests. Under such conditions, some rights of temporary migrant workers in host countries can be regarded as a legitimate outcome of negotiations, while others need to be fixed in advance under a democratic principle of equal protection of all subjected to the laws. Democratic legitimacy also requires that migrants enjoy protection and participation rights as citizens of their countries of origin as well as local citizenship in their countries of residence.
Clinical Features, Survival, and Burden of Toxicities in Survivors More Than One Year After Lung Cancer Immunotherapy
Authors: Hsu Melinda L , Murray Joseph C , Psoter Kevin J , Zhang Jiajia , Barasa Durrant , Brahmer Julie R , Ettinger David S , Forde Patrick M , Hann Christine L , Lam Vincent K , Levy Benjamin , Marrone Kristen A , Patel Tricia , Peterson Valerie , Sagorsky Sarah , Turner Michelle , Anagnostou Valsamo , Naidoo Jarushka , Feliciano Josephine L
Published: August 2022

Introduction

Anti-PD-(L)1 immune checkpoint inhibitors (ICI) improve survival in patients with advanced non-small cell lung cancer (aNSCLC). The clinical features, survival, and burden of toxicities of patients with aNSCLC alive >1 year from ICI initiation are poorly understood.

Materials and Methods

We defined ICI survivors as patients alive >1 year after ICI start and retrospectively reviewed demographics, treatment, and immune-related adverse events (irAEs). Long-term irAEs were defined as ongoing irAEs lasting >1 year; burden of toxicity measures were based on percentage of days a patient experienced toxicity. Using linear and logistic regression, we evaluated association between demographics and disease characteristics with burden of toxicity.

Results

We identified 114 ICI survivors from 317 patients with aNSCLC. Half (52%) experienced an irAE of any grade, and 23.7% developed long-term irAEs. More ICI survivors with irAES in the first year had never smoked (P = .018) or received ICIs as frontline therapy (P = .015). The burden of toxicity in the first year significantly correlated with the burden of toxicity afterward (ρ = 0.72; P < .001). No patients with progressive disease had a high burden of toxicity, and they experienced 30.6% fewer days with toxicity than those with stable disease. Increased duration of therapy was associated with higher odds of experiencing toxicity. Half of ICI survivors with irAEs were still receiving treatment for unresolved irAEs at time of death or last follow-up.

Conclusion

Significant proportions of ICI survivors have unresolved long-term toxicities. These data support a growing need to understand long-term toxicity to optimize management of those treated with ICIs.
Suppression of Phytophthora on Chamaecyparis in Sustainable Horticultural Substrates Depends on Fertilization and Is Linked to the Rhizobiome
Authors: Pot Steffi , De Tender Caroline , Ommeslag Sarah , Delcour Ilse , Ceusters Johan , Vandecasteele Bart , Debode Jane , Vancampenhout Karen
Published: August 2022

Nature management residues (i.e., biomass generated from the management of nature reserves) are promising peat alternatives for horticultural substrates and may have a positive effect on disease suppression because of their microbiological characteristics. Moreover, addition of fertilizer may also affect the rhizosphere microbiome and, accordingly, disease suppression. In this study, we determined the effect of two management residues in horticultural substrates (i.e., chopped heath and acidified soft rush) and two fertilization regimes (i.e., pure nitrogen fertilizer and compound fertilizer) on the suppression of Phytophthora spp. on Chamaecyparis lawsoniana. The bacterial and fungal rhizosphere community was characterized using 16S ribosomal RNA and internal transcribed spacer 2 gene metabarcoding. Soft rush with a compound fertilizer (R2) and chopped heath with a pure nitrogen fertilizer (H1) showed a disease-suppressive effect and showed the largest shifts in microbial community composition compared with peat-based substrates. The disease-suppressive treatments showed differences in their microbial communities. Different genera associated with described biocontrol agents for Phytophthora spp. were found in higher amounts in those treatments. Aspergillus and Trichoderma spp. were highly abundant in H1, while Actinomadura and Bacillus spp. had a high abundance in R2. In addition, the relative abundances of 24 bacterial and 9 fungal genera were negatively correlated with disease severity. Several of those genera, including Bacillus, Chaetomium, and Actinomadura, were significantly more abundant in one of the disease-suppressive treatments. This study shows that disease suppressiveness in sustainable horticultural substrates is dependent on fertilization and can be linked to changes in the microbial rhizosphere communities.
The Expanding Menagerie of Prunus-Infecting Luteoviruses
Authors: Khalili Maryam , Candresse Thierry , Koloniuk Igor , Safarova Dana , Brans Yoann , Faure Chantal , Delmas Marine , Massart Sébastien , Aranda Miguel A. , Caglayan Kadriye , Decroocq Veronique , Drogoudi Pavlina , Glasa Miroslav , Pantelidis George , Navratil Milan , Latour François , Spak Josef , Pribylova Jaroslava , Mihalik Daniel , Palmisano Francesco , Saponari Antonella , Necas Tomas , Sedlak Jiri , Marais Armelle
Published: August 2022

Members of the genus Luteovirus are responsible for economically destructive plant diseases worldwide. Over the past few years, three luteoviruses infecting Prunus trees have been characterized. However, the biological properties, prevalence, and genetic diversity of those viruses have not yet been studied. High-throughput sequencing of samples of various wild, cultivated, and ornamental Prunus species enabled the identification of four novel species in the genus Luteovirus for which we obtained complete or nearly complete genomes. Additionally, we identified another new putative species recovered from Sequence Read Archive data. Furthermore, we conducted a survey on peach-infecting luteoviruses in eight European countries. Analyses of 350 leaf samples collected from germplasm, production orchards, and private gardens showed that peach-associated luteovirus (PaLV), nectarine stem pitting-associated virus (NSPaV), and a novel luteovirus, peach-associated luteovirus 2 (PaLV2), are present in all countries; the most prevalent virus was NSPaV, followed by PaLV. The genetic diversity of these viruses was also analyzed. Moreover, the biological indexing on GF305 peach indicator plants demonstrated that PaLV and PaLV2, like NSPaV, are transmitted by graft at relatively low rates. No clear viral symptoms have been observed in either graft-inoculated GF305 indicators or different peach tree varieties observed in an orchard. The data generated during this study provide a broader overview of the genetic diversity, geographical distribution, and prevalence of peach-infecting luteoviruses and suggest that these viruses are likely asymptomatic in peach under most circumstances.
An Integrated Care Model for Pregnant and Postpartum Individuals Receiving Medication for Opioid Use Disorder
Authors: Ellis Laura Peyton , Parlier-Ahmad Anna Beth , Scheikl Marjorie , Martin Caitlin E.
Published: August 2022

Objectives

Perinatal opioid use disorder is increasing. Integrated obstetric/addiction care models likely optimize parent-infant dyad outcomes, but the ideal combination of services is unknown. This study (1) describes pregnancy-to-postpartum service utilization by people receiving buprenorphine at an integrated Obstetric/Addiction Clinic and (2) explores the association between service utilization and postpartum buprenorphine continuation.

Methods

This retrospective medical record review study uses research registry data from an outpatient Obstetric/Addiction Clinic. All patients are invited to participate in the research registry. For patients who consent, monthly medical record abstractions are conducted beginning with their first clinic visit to collect demographic, obstetric, and substance use disorder treatment variables. Present analyses included patients who delivered an infant between June 2019 and June 2021, started buprenorphine during pregnancy, and were receiving buprenorphine at delivery. Overall service utilization was the number of services (range 0–12) used between 28-weeks gestation and 12-weeks postpartum. Bivariate analyses and multivariable logistic regression assessed associations between service utilization and buprenorphine continuation.

Results

Participants (n = 42) were primarily non-Latinx White (67%) with comorbid psychiatric diagnoses (95%). On average, participants used 6 services; prenatal care, mental health care, and postpartum contraception were most utilized. Overall, 69% of participants continued buprenorphine at 6 months postpartum. This did not differ by level of service utilization (bivariate [P = 0.07], multivariable [P = 0.16]).

Conclusion

Integrated care with a harm reduction focus supports pregnancy-to-postpartum service utilization and buprenorphine continuation in a patient sample at high risk for medication for opioid use disorder discontinuation. Further work is needed to identify evidence-based methods to individualize integrated obstetric/addiction care.
Effect of Medically Tailored Meals on Clinical Outcomes in Recently Hospitalized High-Risk Adults
Authors: Go Alan S. , Tan Thida C. , Horiuchi Kate M. , Laws Denise , Ambrosy Andrew P. , Lee Keane K. , Maring Benjamin L. , Joy Jena , Couch Cathryn , Hepfer Paul , Lo Joan C. , Parikh Rishi V. ,   for the KP NOURISH Study Investigators
Published: August 2022

Background:

Inability to adhere to nutritional recommendations is common and linked to worse outcomes in patients with nutrition-sensitive conditions.

Objectives:

The purpose of this study is to evaluate whether medically tailored meals (MTMs) improve outcomes in recently discharged adults with nutrition-sensitive conditions compared with usual care.

Research Design:

Remote pragmatic randomized trial.

Subjects:

Adults with heart failure, diabetes, or chronic kidney disease being discharged home between April 27, 2020, and June 9, 2021, from 5 hospitals within an integrated health care delivery system.

Measures:

Participants were prerandomized to 10 weeks of MTMs (with or without virtual nutritional counseling) compared with usual care. The primary outcome was all-cause hospitalization within 90 days after discharge. Exploratory outcomes included all-cause and cause-specific health care utilization and all-cause death within 90 days after discharge.

Results:

A total of 1977 participants (MTMs: n=993, with 497 assigned to also receive virtual nutritional counseling; usual care: n=984) were enrolled. Compared with usual care, MTMs did not reduce all-cause hospitalization at 90 days after discharge [adjusted hazard ratio, aHR: 1.02, 95% confidence interval (CI), 0.86–1.21]. In exploratory analyses, MTMs were associated with lower mortality (aHR: 0.65, 95% CI, 0.43–0.98) and fewer hospitalizations for heart failure (aHR: 0.53, 95% CI, 0.33–0.88), but not for any emergency department visits (aHR: 0.95, 95% CI, 0.78–1.15) or diabetes-related hospitalizations (aHR: 0.75, 95% CI, 0.31–1.82). No additional benefit was observed with virtual nutritional counseling.

Conclusions:

Provision of MTMs after discharge did not reduce risk of all-cause hospitalization in adults with nutrition-sensitive conditions. Additional large-scale randomized controlled trials are needed to definitively determine the impact of MTMs on survival and cause-specific health care utilization in at-risk individuals.
The Impact of Pancreatic Enzyme Replacement Therapy on Patients With Advanced Pancreatic Adenocarcinoma
Authors: Landers Amanda , Donaldson Francis , Brown Helen , McKenzie Clare , Pendharkar Sayali
Published: August 2022

Advanced pancreatic cancer has a poor prognosis globally. Patients often develop pancreatic exocrine insufficiency leading to malabsorption. This systematic literature review explores the impact of pancreatic enzyme replacement therapy (PERT) on patients with advanced pancreatic cancer. Data sources include MEDLINE, CINAHL, Embase, Cochrane (CENTRAL), PsychINFO, and Joanna Briggs Institute databases from inception to January 14, 2022, with reference list checking on Google Scholar. Narrative synthesis was used as the eligible studies were likely to be heterogeneous and hard to compare. This synthesis approach uses 4 steps: theory development, preliminary synthesis, exploration of relationships, and assessment of the robustness of the synthesis. Four themes arose from analyzing the study outcomes including PERT education, efficacy of PERT, the patient experience, and lack of awareness regarding enzyme replacement. The included studies did not use validated tools or standardized measurements, which made it difficult to compare or draw conclusions. Pancreatic enzyme replacement therapy shows the potential to improve symptoms, nutrition, weight loss, and survival, but high-quality studies with standardized outcomes have not been completed. Patient and health professional education is required because there seems to be a general lack of awareness about the use of PERT in pancreatic cancer.

Systematic Review Registration: PROSPERO 2020 CRD42020195986
Neurofibromatosis Type 1
Authors: Gauci James , Azzopardi Neville , Babic Darko , Cortis Kelvin , Axisa Benedict
Published: August 2022

Neurofibromatosis type (NF-1) is an autosomal dominant disorder characterized predominantly by neurocutaneous manifestations. Involvement of the gastrointestinal tract is uncommon but is associated with a significant risk of malignancy. There are a handful of case reports linking NF-1 with pancreatic neuroendocrine tumors; these include gastrin-secreting variants with the attendant Zollinger-Ellison syndrome. We present the case of a 52-year-old lady who presented with recurrent peptic ulceration and diarrhea. Serum gastrin levels were elevated and magnetic resonance imaging demonstrated the presence of a pancreatic lesion with multiple liver metastases. The lesion was moderately fludeoxyglucose avid on positron emission tomography-computed tomography. Endoscopic ultrasonography-guided sampling revealed the presence of synaptophysin positive neuroendocrine cells with positive gastrin immunostaining. A conservative approach was adopted, and the patient's symptoms improved on proton pump inhibitors. Zollinger-Ellison syndrome is an important condition, which should be kept in mind in the patient with NF-1 who presents with recurrent peptic ulceration and diarrhea. The emerging association between these 2 conditions is being examined on a cellular and immunohistochemical level.
Incidence and Causative Organisms of Bacteriuria in Children With Cancer: A 9-Year Experience in a Tertiary Pediatric Center
Authors: Mitsuboshi Akari , Kishimoto Kenji , Ito Yusuke , Ishida Toshiaki , Kasai Masashi , Hasegawa Daiichiro , Kosaka Yoshiyuki
Published: August 2022

Although infection is common in patients with cancer, the distribution of causative agents and the proportion of resistant bacteria in patients with urinary tract infection remain unknown. The aim of this study was to describe the incidence, the causative agents, and the proportion of antimicrobial resistance in bacteria cultured from urine of hospitalized children with cancer. A single-center retrospective chart review of patients with cancer admitted between 2012 and 2020 was performed to identify patients with positive urine culture. Overall, 61 (0.9%) of 7107 patients were identified to have positive urine cultures. Among them, 25 patients (41%) had symptomatic bacteriuria. The most common pathogenic bacterium among all patients was Escherichia coli (E. coli) (n=15, 25%), followed by Enterococcus sp. (n=14, 23%), Klebsiella sp. (n=12, 20%), and Pseudomonas aeruginosa (P. aeruginosa) (n=12, 20%). Extended spectrum β-lactamases–producing E. coli and Extended spectrum β-lactamases–producing Klebsiella pneumoniae were detected in 1 patient (2%) and 4 patients (7%), respectively. No multidrug-resistant P. aeruginosa and vancomycin-resistant Enterococcus were detected. The incidence of bacteriuria was found to be low in children with cancer. The distribution of causative agents of bacteriuria in children with solid tumors and hematologic diseases may be different from that in previously healthy children.
Work Readiness of Newly Licensed RNs
Authors: Walters Gloria , Hoffart Nancy , Kring Daria , Whitley Tracey , Horne Lindsey , Almotairy Monir
Published: August 2022

OBJECTIVE

The aim of this study was to examine the work readiness of newly licensed RNs (NLRNs) based on demographics, education, and work experiences.

BACKGROUND

Work readiness is the extent to which new graduates possess qualities and competencies associated with workplace success. Work readiness of NLRNs complements their clinical knowledge and skills and has been shown to predict job satisfaction and work engagement.

METHODS

Two hundred ninety-seven NLRNs participating in the nurse residency program of a health system in the southeast region of the United States were surveyed using the Work Readiness Scale–Graduate Nurse.

RESULTS

Scores on all readiness dimensions were high. Analysis revealed unexpected differences in readiness dimensions based on race, nursing degree, and completion of a nurse externship program.

CONCLUSIONS

Work readiness adds to our understanding of factors that can affect the transition of NLRNs into the work setting. Further research is needed to understand how work readiness develops over time, factors that predict work readiness, and its relationship to NLRN retention and other outcomes.
The Resolution of Severe Iron-Deficiency Anemia After Successful Eradication of Helicobacter pylori in Teenagers
Authors: Kato Seiichi , Gold Benjamin D. , Kato Ayumu
Published: August 2022

Objectives:

Long-term follow-up studies with Helicobacter pylori eradication therapy in children with H. pylori-associated iron-deficiency anemia (IDA) are scarce. We investigated whether successful H. pylori eradication would result in maintaining resolution of recurrent and/or refractory IDA in a cohort of teenagers in Japan.

Methods:

In this case series, 7 H. pylori-infected patients with recurrent and/or refractory IDA (12–16 y old) received successful eradication therapy and were then followed for a median of 20 months (range, 9–76 mo) after oral iron supplementation therapy (1–4 mo) was discontinued. Five patients of our study cohort participated in rigorous sports activities.

Results:

No visual appearance of ulcerations or erosions was found by esophagogastroduodenoscopy. In all patients studied, the gastric biopsies showed histological evidence of chronic gastritis without significant atrophy and intestinal metaplasia. Compared with the baseline (median values: hemoglobin, 6.3 g/dL; serum iron, 9 μg/dL; serum ferritin, 1.5 ng/mL), values of hemoglobin (P < 0.001), serum iron (P < 0.005), and ferritin (P < 0.001) significantly increased, on average, 2–3 months after eradication therapy and these iron indices were maintained at the same or higher levels at the endpoint of follow-up (median values: 14.2 g/dL, 102 μg/dL, and 29.3 ng/mL, respectively). No patient had recurrence of IDA at the time of final follow-up.

Conclusions:

H. pylori infection can be closely associated with recurrent or refractory IDA in teenage children. It is speculated that increased iron demands as a result of growth spurt in adolescents may play a synergistic role in combination with H. pylori in the pathogenesis of IDA.
Morphological Changes in Total and Inferior Part of Maxillary Sinus After Le Fort I Osteotomy, as Determined by Cone-Beam Computed Tomography
Authors: Qiu Tiancheng , Yang Rong , Qiu Lixin , Yi Biao , Liu Xiaojing , Li Zili
Published: August 2022

To investigate morphological changes of the total and inferior part of the maxillary sinus following Le Fort I osteotomy. 21 skeletal class II and 49 skeletal III patients who underwent orthognathic surgery were enrolled in this retrospective study. Cone-beam computed tomography taken before (T1) and 6 to 24 months after (T2) orthognathic surgery were imported into Mimics 20.0 software to analyze morphological changes of the total and inferior part of the maxillary sinus. Volume of the whole maxillary sinus was significantly reduced after surgery (P≤0.008), while the volume of the inferior part of the maxillary sinus was significantly greater than before surgery (P≤0.004). Maxillary sinus floor moved occlusally after Le Fort I osteotomy. Movement in the pitch direction of the posterior maxilla affected the state of the maxillary sinus mucosa after orthognathic surgery. Le Fort I osteotomy exerts a significant impact on the morphology of the total and inferior part of the maxillary sinus.