bluuebunny/crossref_metadata_2025 huggingface dataset:
DEVELOPMENT OF FUTURE DESIGNERS CREATIVE THINKING IN THE MASTERING TECHNICAL GRAPHICS PROCESS
Authors:   Nosov Magnitogorsk State Technical University, city of Magnitogorsk, Russia, Zhdanova N.S. , Antonenko J.S. ,   Nosov Magnitogorsk State Technical University, city of Magnitogorsk, Russia, Ekaterinushkina А.V. ,   Nosov Magnitogorsk State Technical University, city of Magnitogorsk, Russia
Published: December 2023

We reviewed the experience of developing creative thinking of students studying in the “Design” major. A team of teachers included “technical graphics” into the already existing integrative model of professional training for designers. For this purpose, graphic tasks were specially developed that build readiness to act in non-standard situations by using the creative potential of each student. The experimental work was carried out in three stages. At the first stage, a system of graphic tasks was developed that would allow the academic discipline “Technical Graphics” to be included in the general block of professional competencies of the integrated model of designer training. The traditional course included tasks to transform the shape of an object, as well as a group of creative tasks, among which tasks with design elements turned out to be especially significant. The experiment was carried out over 10 years. At the beginning of each academic year, a control sample of the components of students’ creative thinking was carried out when solving the simplest type of problems. At the second stage, during the year, the theoretical and practical fundamentals of drawing were mastered. At the same time, students’ abilities for abstract thinking, mastery of logical operations of analysis and synthesis developed, and the ability to think variably, systematically, rationally, and originally was developed. At the same time, spatial concepts were formed, which largely determine the level of professional training of any designer. At the end of the year, the same components of creative thinking were tested, but when solving problems of increased complexity. The work carried out showed that technical graphics can successfully develop the creative thinking abilities of students. This increases students’ readiness for self-development and self-realization in professional design activities.Keywords: creative thinking, design training, technical graphics.
PUBLIC DISCUSSION AS A MEANS OF DEVELOPING SPEECH CREATIVITY: THE EXPERIENCE OF A YOUNG TEACHER
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Zhirnova A.I.
Published: December 2023

Modern education in the 21st century is shaped by the trend of universality. The pedagogical community is preparing for the realities where a fundamental skill of future teachers is the ability to “see the big picture.” However, the dominance of reproductive tasks suppresses the personal and professional initiative of educators. This results in a loss of the ability to express professional positions creatively and independently, leading to a lack of creativity in solving complex pedagogical situations. It is important to remember that the speech of a future teacher is not only the primary tool in educational activities but also an example for students to learn and emulate. The development of the future teacher’s speech creativity through discussion helps mitigate the identified shortcomings. Speech creativity in this context encompasses the ability to engage in dialogue with various audiences (colleagues, students, parents, administration), mastery of intonation and voice tone (as factors influencing engagement), and the ability to speak spontaneously, coherently, and clearly. Achieving these skills for future teachers is facilitated by public discussion as a platform for practicing their communicative competencies. Public discussions offer advantages such as the opportunity to prepare in advance, develop a presentation strategy, and simultaneously prepare spontaneous responses to audience questions, engage in discussions with colleagues, and receive feedback. Thus, the central purpose of public discussion as a means of developing speech creativity is practical training, self-development, and active participation in the academic sphere of higher education. Changes in sociocultural situations, consideration of intercultural communication contexts, and modern educational trends in higher education highlight the challenge of preparing future teachers professionally. Developing the speech creativity of future teachers through public discussion enables the production of prepared and contemporary specialists capable of addressing educational challenges.
PSYCHOLOGICAL FEATURES OF THE FEAR OF DEATH PERCEPTION IN MEN AND WOMEN OF I MATURITY
Authors:   Orenburg State University, Orenburg, Russia, Zubova L.V.
Published: December 2023

The psychological and pedagogical perception of fear in men and women of first maturity was studied. This problem is widely discussed in the scientific community in connection with social needs and challenges occurring recently. In connection with the coronavirus pandemic and foreign policy tensions, this problem has caused great resonance in the scientific community, reflected in various scientific sources analyzing the problem of fear of death. Whether it is the basic basis of personality or a permanent crisis, tension and anxiety — all this is undoubtedly one of the most powerful experiences of a person for the rest of his life. A theoretical study was conducted of approaches to the perception of the fear of death and its experience at various stages of a person’s life, taking into account the individual psychological characteristics of the individual: mental pathology, depression, low need for achievement, reflexivity, sensitivity, locus control, religiosity and others. It is necessary to help a person overcome the fear of death, to reorient him towards important vital needs. Empirical material shows anxiety about the fear of death in middle-aged people. Gender and correlation analysis of the study reflects the whole range of facets of its attitude to this problem. The perception of death has a great impact on a person and his interpersonal relationships, as well as the perception of the picture of the world as a whole. This is especially important during the period of first maturity in men and women, which determines the sample for empirical research.
UPDATING THE POTENTIAL OF SUBJECT TRAINING OF FUTURE TEACHERS FOR THE LABOR EDUCATION OF PRIMARY SCHOOLCHILDREN
Authors:   Orenburg State Pedagogical University, Orenburg, Russia, Allagulov A.M. , Sarmutdinova G.B. ,   Orenburg State Pedagogical University, Orenburg, Russia
Published: December 2023

We have theoretically studied the potential of subject training of future teachers for the labor education of primary schoolchildren. It is noted that the labor skills that are acquired in educational and extracurricular activities of schoolchildren are one of the most important factors in the formation of activity. Together with other manifestations of social activity, we note such an important manifestation as collectivism, although we do not single it out ourselves. A preliminary testing of the methodology we developed for determining the level of presentation of pedagogical activity in the field of labor education of primary schoolchildren was carried out. Based on the fact that this definition is familiar to schoolchildren, we decided to establish what meaning they attach to the concept of social activity, what knowledge about social activity characterizes them. Depending on the number of manifestations named by students, knowledge was conditionally distributed into levels: 1 — complete knowledge of the main manifestations of labor activity — no; 2 — incomplete knowledge of manifestations of labor activity — 2 people; 3 — fragmentary knowledge — 13 people; knowledge about this phenomenon was not found — 13 people. The obtained material allowed us to classify the ideas of pedagogical activity in the field of labor education of primary schoolchildren from the point of view of its ideological, moral and active essence. Naturally, the essay provided richer material than the questionnaire, since the students saw the diverse, interesting activities of a particular person. It was easier for the students to grasp and identify manifestations characteristic of a worker, which are generally difficult for schoolchildren to talk about.
QUINTESSENCE TOTAL ECOLOGICAL ENGINEERING IN DESIGN
Authors:   Plekhanov Russian University of Economics, Moscow, Russia, Reshetova M.V.
Published: December 2023

Recently, a new round of transformation has been taking place in design thinking, which consists of considering a design object as a single whole with nature. Nature is considered from the point of view of a formative source, the resource of which can be used in the design and construction of environmental objects in order to create new bioforms, eco-materials and structures to reduce energy consumption while maintaining comfort. The push for sustainable design has intensified with the launch of the Building Research Institute’s Environmental Assessment Method (BREEAM). It introduces the first green building rating system. In addition, the United States Green Building Council (USGBC) has formulated new criteria aimed at improving the environmental performance of buildings through its Leadership in Energy and Environmental Design (LEED). In Russia, the existing “Green” standards create practices for solving broader problems of sustainable development, such as zero-energy construction concepts, living, regenerative and restorative construction concepts that improve the natural environment or simulate natural processes. This will initiate the search for new design strategies using the tools of immersive design concepts for the development of socially-oriented projects aimed at supporting the global trend of total environmental design. The article analyzes the artificial and natural elements of the exposition complexes from the perspective of ecological design. In Russia, the existing “Green” standards create practices for solving broader problems of sustainable development, such as zero-energy construction concepts, living, regenerative and restorative construction concepts that improve the natural environment or simulate natural processes. This will initiate the search for new design strategies using the tools of immersive design concepts for the development of socially-oriented projects aimed at supporting the global trend of total environmental design. The article analyzes the artificial and natural elements of the exposition complexes from the perspective of ecological design. Examples of the organization of sensory, interactive exhibition and development spaces are given. The role of ecological design in modern information and educational culture is revealed. The article discusses the principles of integration of the virtual environment with the information space, describes the structure and technology of obtaining information, structuring and compiling databases, coordinating, interacting and managing design forms and objects.
MENTORING MODEL IN CREATIVE COMPETITIONS ON THE EXAMPLE OF THE “DESIGN FACTORY” PROJECT
Authors:   Orenburg State University, Orenburg, Russia, Tuysina D.M. , Bobretsova A.V. ,   «TourAccelerator», Moscow, Russia
Published: December 2023

Recently, there has been a need in society for ways to transfer practical knowledge, especially in creative types of professional activity. The practice of “mentoring” is a form of communication in which an expert has professional competencies and universal knowledge and skills. Analysis of the theoretical material made it possible to determine that mentoring as a process of personal interaction allows you to speed up the stages of training, while actually having a built-in expert tool for monitoring the quality of training. The inclusion of the practice of “tracking” in competitive projects in the design industry represents a modern type of mentoring in communications, that is, a way of transferring knowledge from experienced specialists. During the implementation of the creative competitive project “Design Factory”, the features of the competencies of the “trackers” were identified and presented, in particular the features of interaction with a group of competitors: expertise in their field of design (hard), empathy and communication skills (soft), balance and ability to learning (hard). The key functions of the tracker in the process of communication with design teams have been identified: consider hypotheses and highlight the most successful one, recognize the crisis and find solutions, keep deadlines. The proposed tracking model is a scheme of interaction between all participants in the competitive project, while the tracker relies on clarifying questions as a way to correct the process of group thinking. The parameters for assessing the tracker’s performance during the implementation of the “Tracker School” training program of the “Design Factory” competition in the context of the tracking model are identified: speed and quality of feedback; competent communication; “reachability” to the end. Thanks to the tracker’s competencies, the design process in the competition increases the speed and accuracy of the solution developed by teams, and also makes the project cycle more predictable. It is concluded that tracking as a mentoring model is based on behavioral models of communication within the team, tracker management of involvement in the design process of creative project participants.
MODERN ECONOMY: ARE WE GOING TO THE EAST?!
Authors:   Russian State University for the Humanities, Moscow, Russia, Ilin A.B.
Published: December 2023

The paper presents the author’s scientific views on the current state of the world economy, its either Western or Eastern self-determination in the process of economic history. The relevance of the research is determined by the transformation of relations between states, their strategic management and the development or stagnation of the business environment. The current situation poses the question of a civilizational choice for many countries: to join the BRICS, to declare their power in the G7, to determine their own independence or to be an observer. The author, through the genesis of the “Eastern” economy, the “Russian Idea” and the development of the Chinese and Middle Eastern economies, makes conclusions on the further path of the Russian economy. Definitely, due to the limited volume of the material, the author considers the branches that refer to his scientific research interests and concepts. The history of managerial and economic thought, as well as the genesis of public administration, allows to determine the prerequisites for a modern economy shaping. The drivers of the economy, to which the author refers China and the Persian Gulf countries, are transforming the business environment today. China is striving for a multi-polarity of the world, and the Arab Emirates are trying to ensure the future of generations through petrodollars, investing in trending industries and thereby forming a positive image of their actions, including mega-events. For Russia, on the one hand, new opportunities are opening for the entrepreneurial environment development, its own entrepreneurial culture shaping, new areas of entrepreneurial activity, import substitution. On the other hand, in modern conditions it is impossible to do without programs and projects to support the business environment, and, at the same time, strengthen control over the production and sale of goods and services. The article is rather conceptual, since it represents the author’s view of the current situation. Taking into consideration that the planning horizon today is limited to a mega-short-term period, the relevance of many scientific publications, in particular, J. Byrnes, [1], A. N. Shokhin [2], I. V. Guskova [3], A. L. Kudrin [4], M. Mazzucatto [5], may change with regular frequency.
PHILOSOPHICAL UNDERSTANDING OF FEAR AS THE BASIS OF HUMAN EXISTENCE
Authors:   Orenburg State Pedagogical University, Orenburg, Astafyev D. A. ,   Orenburg Branch of the Academy of Labor and Social Relations, Orenburg, Russia, Maksimov A. M. ,   Orenburg State Medical University, Orenburg, Russia
Published: December 2023

The study is relevant due to the fact that the life of a modern person is permeated with fears, both real and virtual. A person cannot imagine his life without fear; even his own existence causes fear. Despite the fact that fear has always accompanied a man, at present, due to the increase in self-awareness and many other factors, in our opinion, fear is becoming the true basis of human existence in the world. The purpose of this study is to analyze the problem of fear as the basis of human existence in various historical periods and, in particular, at the present stage of human development. The achievement of the stated goal was facilitated by the solution of the following tasks. 1. To analyze the evolution of philosophical ideas about fear in various historical periods. 2. Based on the analysis, to draw conclusions and show that the rethink of fear is carried out in the New Age, since this period is a turning point in changing the role of fear. It is at this time that its individualization occurs, and it acquires a pronounced social character. 3. Particular attention should be paid to the analysis of existential philosophy, in which fear is considered as one of the key foundations of human existence and the main companion of a man in the modern era. Human existence and fear become one whole, connected by an inextricable thread. The methodology of this study is based on a dialectical approach. This approach was implemented through the use of a set of research methods of induction, deduction, analysis, comparison and synthesis, which are of a general scientific character. Analyzing the problem of fear in modern reality, we came to the conclusion that the XXI century is an era when fear begins to accompany an individual in his daily existence, becomes a mass phenomenon and is formed in the public consciousness through various information channels: the media, the Internet, expert opinion, etc. The modern world has also generated completely new types of fears, which are a direct consequence of technologization, informatization, and digitalization of society. The appearance of the “pandemic of fear” amid the COVID-19 pandemic reinforced our idea that in the XXI century fear has become the true basis of human existence.
ORGANIZATIONAL AND ECONOMIC MECHANISM OF PROCUREMENT ACTIVITIES OF OIL INDUSTRY ENTERPRISES: METHODOLOGICAL ASPECT
Authors:   Perm State National Research University, Perm, Russia, Sheshukova T. G.
Published: December 2023

Current legislation in the field of public procurement focuses on ensuring maximum transparency and openness of procurement at different stages of its implementation. However, at present, the methodology for assessing the effectiveness of procurement by commercial organizations is imperfect. The research topic is relevant. The purpose of the study is to develop the fundamentals of methodological support for the procurement system of oil refineries. The object of the study is the oil company LLC “LUKOIL – PERM” in the “geological exploration, oil and gas production” segment. The theory and practice of the mechanism for carrying out procurement activities of oil producing enterprises is the subject of research. The concepts and types of procurement, legal regulation of procurement activities in commercial organizations are revealed. An analysis of methods for assessing the effectiveness of procurement is provided. Systematization of information and technological support for procurement activities at oil producing enterprises was carried out. The main factors for assessing the effectiveness of the existing procurement system are identified: price, reliability and time. Based on the study of practical aspects, significant shortcomings were identified: procurement planning is unreliable, digital technology is not used enough, there is no system of criteria for assessing demand planning and procurement procedures. In this regard, in order to more accurately plan demand and apply fair prices, the corporate system of dictionaries and reference books (KSSS) of the LUKOIL Group has been improved. A system has been developed for assessing the effectiveness of procurement procedures in an oil producing company, which makes it possible to determine the effectiveness of inventories of material and technical resources (MTR) for all inventory items. A methodology has been developed for assessing the effectiveness of demand planning and budgets according to the data of the integrated management system of oil and gas producing subsidiaries (IMS NGDO). To determine the level of competition of potential counterparties, an original method for assessing the effectiveness of the supplier selection process is proposed. The practical significance lies in the possibility of applying the developed methodology in the practice of organizational and economic support for procurement at enterprises. The study may be useful for specialists involved in procurement activities, for managers and those making management decisions related to achieving the goals of sustainable development of the organization.
TAKING INTO ACCOUNT THE COMPLEXITY IN THE TASKS OF TRANSPORT DEMAND
Authors:   Tula State University, Tula, Russia, Agureev I. E. , Akhromeshin A. V. ,   Tula State University, Tula, Russia, Pyshnyi V. A. ,   Tula State University, Tula, Russia
Published: December 2023

The article describes the theoretical basis for taking into account the complexity in solving problems of transport demand, the analysis of the concept of “self-organized criticality” is carried out. The problems of describing complex conduct in transport systems are solved, the prerequisites or causes of complex behavior are indicated, the traditional definitions of a “complex transport system” are formalized. Examples of some models demonstrating complex behavior in transport systems are given. Objective: formulation of research directions in the theory of transport systems, which should be developed with the help of conceptual and mathematical devices of individual sciences, such as complexity theory, nonlinear dynamics, to solve problems of transport demand, accompanied by flows of various events and elements in transport macrosystems, to take into account the complexity of problems in the theory of transport systems in modeling the dynamics of transport demand. Approaches used: development of mathematical models of nonlinear transport systems demonstrating complex behavior, including models with power-law distribution of system characteristics within the framework of self-organized criticality, as well as models demonstrating bifurcations. Methods and (or) methodological apparatus of research: methods of the theory of self-organized criticality and synergetics, allowing to take into account the properties of a complex system. The scientific novelty lies in the use of methods and approaches of the theory of self-organized criticality and complexity theory for a wide class of models of transport systems used in problems of transport demand and based on traffic flow models. Directions for further research, recommendations: it is required to analyze real statistics of the behavior of transport systems that correspond to various states of the transport system, including complex behavior, as well as the formulation and solution of problems of the theory of transport macrosystems.
THEORETICAL JUSTIFICATION OF THE CHOICE OF THE SPEED MODE DURING THE DRIVING TEST EXPRESS DIAGNOSTICS OF TRANSMISSION UNITS
Authors:   Nizhny Novgorod State Technical University named after R. E. Alekseev, Nizhny Novgorod, Russia, Leliovsky K. Y.
Published: December 2023

The relevance of the study is determined by the need to solve the problem of operational management of the current technical condition of the rolling stock. Based on this, technical diagnostics activities become important because they allow you to quickly identify the current technical condition of the vehicle in question. At the same time, it is important, even at the stage of planning diagnostic measures, to choose such operational modes of movement along the test section that would ensure the best information content of the test runs. The theoretical substantiation of the choice of speed modes of arrivals of the studied vehicles along the test section of the road during express diagnostics was the purpose of this work. Research methods: analytical mechanics, differential methods, matrix calculus methods, mathematical numerical methods. The main results are in the proposal of a dynamic model of the vehicle transmission, which takes into account the disturbing effects from the engine and from the support base of the test section, where diagnostic runs are carried out. The amplitude-frequency characteristics of vibration accelerations of the vehicle body are calculated when it moves at given speeds along the simulated test diagnostic section. The practical significance of the study is confirmed by the results of the analysis of the obtained graphs, during which a conclusion was made about the most vibration-dangerous frequency ranges. This is important, since vibrations that occur at certain frequencies, which are directly dependent on the speed of movement, as a rule, cause the most intense responses in specific components and parts of transmission units. Further research is related to the theoretical substantiation of the choice of rational ranges of speed modes of the studied vehicles on the test diagnostic section of the support base, taking into account the characteristics and features of its surfaces. The results of the work are aimed at improving the system of maintenance and repair of the rolling stock of motor vehicles, namely, its diagnosis to determine the presence and degree of development of operational defects and damage, as well as the current technical condition of the transmission units.
Role of deep brain stimulation (DBS) in addiction disorders
Authors: Iqbal Javed , Mansour Mohammad Naser Mohammad , Saboor Hafiz Abdus , Suyambu Jenisha , Lak Muhammad Ali , Zeeshan Muhammad Hamayl , Hafeez Muhammad Hassan , Arain Mustafa , Mehmood Maria , Mehmood Dalia , Ashraf Mohammad
Published: December 2023

Background:

Addiction disorders pose significant challenges to public health, necessitating innovative treatments. This assesses deep brain stimulation (DBS) as a potential intervention for addiction disorders.

Methods:

A literature review was carried out with a focus on the role of DBS in addiction disorders and its future implications in neurosurgical research.

Results:

The online literature shows that DBS precisely modulates certain brain regions to restore addiction-related neural circuits and promote behavioral control.

Conclusion:

Preclinical evidence demonstrates DBS’s potential to rebalance neural circuits associated with addiction, and early clinical trials provide encouraging outcomes in enhancing addiction-related outcomes. Ethical considerations, long-term safety, and personalized patient selection require further investigation.
Long-term follow-up of Parkinsonian patients operated on with deep brain electromodulation without intraoperative microrecording
Authors: Lopez Darelys Teresa , Manzano Gabriel E. , Medina Asveth , Prieto Maria Jose , Abud Juan Pointcarré , Salazar Luis , Vargas Maria Fernanda , Torres Napoleon , Sacchettoni Sergio Antonio
Published: December 2023

Background:

Deep brain electromodulation (DBEM), also known as deep brain stimulation in different intracerebral targets, is the most widely used surgical treatment due to its effects in reducing motor symptoms of Parkinson’s disease. The intracerebral microelectrode recording has been considered for decades as a necessary tool for the success of Parkinson’s surgery. However, some publications give more importance to intracerebral stimulation as a better predictive test. Since 2002, we initiated a technique of brain implant of electrodes without micro recording and based solely on image-guided stereotaxis followed by intraoperative macrostimulation. In this work, we analyze our long-term results, taking into account motor skills and quality of life (QL) before and after surgery, and we also establish the patient’s time of clinical improvement.

Methods:

This is a descriptive clinical study in which the motor state of the patients was evaluated with the unified Parkinson’s disease scale (UPDRS) and the QL using the Parkinson’s disease QL questionnaire 39 questionnaires before surgery, in the “on” state of the medication; and after surgery, under active stimulation and in the “on” state.

Results:

Twenty-four patients with ages ranging from 37 to 78 years undergoing surgery DBEM on the subthalamic nucleus were studied. An improvement of 41.4% in motor skills and 41.7% in QL was obtained.

Conclusion:

When microrecording is not available, the results that can be obtained, based on preoperative imaging and clinical intraoperative findings, are optimal and beneficial for patients.
Inteligencia artificial en educación superior
Authors: Bellomo Santiago Tomás
Published: December 2023

El presente artículo propone un modelo de análisis para orientar el discernimiento y posicionamiento en torno al uso de la IA en educación superior. Analizaremos los cuatro posibles usos de la IA que más incidencia tendrán en esta si se considera el actual desarrollo de esta tecnología. Ellos son: la co-construcción de conocimiento, el uso de IA para tutoría o mentoreo, el auge de las plataformas adaptativas y la capacidad predictiva. Propondremos un ejercicio de análisis para cada uso apelando a algunas de las dimensiones del modelo propuesto para orientar sobre su utilización. El resultado es fecundo, en tanto advierte sobre el riesgo de parcializar el análisis perdiendo de vista las implicancias y los compromisos más profundos que exige el discernimiento sobre el uso de la IA.
Applied Ethics at Corvinus Business Ethics Center
Authors: Haaz Ignace
Published: December 2023

Between practical ethics, which seeks to define a wide range of ethical norms and ways of ethical reasoning on firm philosophical basis, including the definition of the foundation of ethics, and business ethics, environmental ethics or health ethics the difference is only about the degree we get to apply practically ethics. The Business Ethics Center of Corvinus University of Budapest, lead by Prof. Laszlo Zsolnai, takes all these levels very seriously. The external observer who would want to review the activities of the Center would immediately get in trouble if all that he would expect is either great theories on practical ethics, or only concrete observations on how, in some precise context, ethics is applied by economic science professionals. Indeed, as we shall review, the 30 Years Report of the Business Ethics Center of Corvinus University Budapest presents the most important conferences and workshops that they organized, describes significant books they published, and summarizes the main findings of their decades-long research. Crucially, the functioning of the Center is based on the conviction that ethics is a relevant aspect of all levels of economic activity, from individual and organizational to societal and global. Business ethics is practiced by the Center as an action-oriented, interdisciplinary scientific inquiry where normative and descriptive elements are intermingled.
Ethics as a Way of Life
Authors: Rispler Clara , Yakov Gila
Published: December 2023

The dynamic landscape of ethics in higher education is pivotal as organizations and individuals navigate diverse stakeholder needs. Ethical responsibility becomes an integral facet of all professionals, highlighting the crucial role of ethical education in preparing students for post-graduation success. The acquisition of ethical competence, rooted in knowledge of ethical principles, equips students with the tools to make ethical decisions, shaping their ethical behavior and responses. Yezreel Valley College exemplifies this commitment, with a well-defined Code of Academic Ethics reflecting universal values and principles, overseen by the College Ethics Committee. In summary, this case study offers insights into Yezreel Valley College's ethical education practices, emphasizing the significance of ethics in higher education and the dynamic interplay between ethics and professionalism. The college's proactive approach positions it as a leader in addressing ethical challenges and adapting to changing environments while fostering ethical competence in its students.
Reversibly reactive affinity selection mass spectrometry enables maturation of covalent peptides
Authors: Zhang Peiyuan , Ye Xiyun , Wang John C.K. , Baddock Hannah T. , Jensvold Zena , Foe Ian , Loas Andrei , Eaton Dan L. , Hao Qi , Nile Aaron H. , Pentelute Bradley L.
Published: December 2023

Covalent peptides have found widespread applications as activity-based probes and as irreversible therapeutic inhibitors. Currently, there is no rapid, label-free, and highly tunable affinity selection method to enrich covalent reactive peptides from synthetic libraries. We address this challenge by developing a reversibly reactive affinity selection platform enabled by tandem high resolution mass spectrometry (MS/MS) to identify covalent peptide binders to native protein targets. It uses mixed disulfides to build reversible peptide-protein conjugates that can enrich crosslinked peptides that after reduction can be sequenced with MS/MS. Using this platform, we achieved maturation of covalent peptide binders against two oncoproteins, human papillomavirus 16 early protein 6 (HPV16 E6) and peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (Pin1). The resulting peptides selectively covalently crosslink Cys58 of E6 with 96% yield in 4 hours at 37 °C and Cys113 of Pin1 with >99% yield in 1 hour at room temperature, respectively. This approach enables the identification of highly selective covalent peptide inhibitors for diverse molecular targets, introducing an applicable method to assist pre-clinical therapeutic development pipelines.
Nanocellulose in Textiles: A Potential Resource for Sustainable Textile Manufacturing
Authors: Sayam
Published: December 2023

In recent times, there has been a discernible focus on the development of environmentally friendly and sustainable biomaterials obtained from renewable sources. Scientists are now investigating the prospective applications of nanocellulose, a biocompatible substance derived from natural cellulose. The aforementioned substance exhibits notable characteristics, such as a substantial surface area to volume ratio, with its compatibility with biological systems and capacity to undergo degradation. Nanocellulose has the capability to undergo transformation into nanofibers and nanocrystals, so enabling the generation of diverse structures, including elongated nanofibers, suspensions, and films. In the textile industry, there is a growing need to adopt sustainable techniques in order to address and minimize the negative environmental impacts. The current focus is on the advancement of environmentally sustainable alternatives in the realm of textile production, namely cellulose-based materials. These textiles are being created using processes that aim to minimize water pollution. In addition, recent advancements in dyeing methods have used nanocellulose to effectively reduce water consumption and eliminate the need for toxic materials. Nanocellulose nanocomposites, such as nanofibrillated celluloses (NFCs) and cellulose nanocrystals (CNCs), are increasingly used as fillers in textile nanocomposites to enhance their mechanical characteristics due to their cost-effectiveness and recyclability. The advancements achieved in the field of nanocellulose-based materials and technology exhibit considerable promise in the development of ecologically friendly solutions across several industries.
A fast, convenient, polarizable electrostatic model for molecular dynamics
Authors: Wang Liangyue , Schauperl Michael , Mobley David L. , Bayly Christopher , Gilson Michael K.
Published: December 2023

We present an efficient polarizable electrostatic model, utilizing typed, atom-centered, polarizabilities and the fast direct approximation, designed for efficient use in molecular dynamics (MD) simulations. The model provides two convenient approaches to assigning partial charges in the context of the atomic polarizabilities. One is a generalization of RESP, called RESP-dPol, and the other, AM1-BCC-dPol, is an adaptation of the widely used AM1-BCC method. Both are designed to accurately replicate gas-phase QM electrostatic potentials. Benchmarks of this polarizable electrostatic model against gas-phase dipole moments, molecular polarizabilities, bulk liquid densities, and static dielectric constants of organic liquids, show good agreement with the reference values. Of note, the model yields markedly more accurate dielectric constants of organic liquids, relative to a matched non-polarizable force field. MD simulations with this method, which is currently parameterized for molecules containing elements C, N, O, and H, run about only 3.6-fold slower than fixed charge force fields, while simulations with the self-consistent mutual polarization average 4.5-fold slower. Our results suggest that RESP-dPol and AM1-BCC-dPol afford improved accuracy, relative to fixed charge force fields, and are good starting points for developing general, affordable, and transferable polarizable force fields. The software implementing these approaches has been designed to utilize the force field fitting frameworks developed and maintained by Open Force Field Initiative, setting the stage for further exploration of this approach to polarizable force field development.
Transfer Learning Graph Representations of Molecules for pKa, 13C-NMR, and Solubility
Authors: El Samman Amer Marwan , De Castro Stefano , Morton Brooke , De Baerdemacker Stijn
Published: December 2023

We explore transfer learning models from a pre-trained graph convoluntional neural network representation of molecules, obtained from SchNet, 1 to predict 13 C-NMR, pKa, and logS sol- ubility. SchNet learns a graph representation of a molecule by associating each atom with an “embedding vector” and interacts the atom-embeddings with each other by leveraging graph- convolutional filters on their interatomic distances. We pre-trained SchNet on molecular energy and demonstrate that the pre-trained atomistic embeddings can then be used as a transferable representation for a wide array of properties. On the one hand, for atomic properties such as micro-pK1 and 13 C-NMR, we investigate two models, one linear and one neural net, that inputs pre-trained atom-embeddings of a particular atom (e.g. carbon) and predicts a local property (e.g. 13 C-NMR). On the other hand, for molecular properties such as solubility, a size-extensive graph model is built using the embeddings of all atoms in the molecule as input. For all cases, qualitatively correct predictions are made with relatively little training data (< 1000 training points), showcasing the ease with which pre-trained embeddings pick up on important chemical patterns. The proposed models successfully capture well-understood trends of pK1 and solu- bility. This study advances our understanding of current neural net graph representations and their capacity for transfer learning applications in chemistry.
Improving the diversification of herbal pastries and digital marketing applications to increase product sales
Authors: Setiyoko Agus , Lestari Rani Dwi , Wulandari Ika
Published: December 2023

Members of KWT Sewagati Pasekan Lor encountered difficulties as a result of their lack of knowledge and expertise about the diversification of various processed herbal pastries, food labeling and packaging technology, and digital-based product marketing. This volunteering project aims to improve members' knowledge and abilities in relation to the variety of processed herbal pastries, label and packaging technology, and digital-based marketing. The community service method used is counseling which includes theories regarding the diversification of processed herbal pastries, brands, and types of packaging, as well as digital-based marketing practices. The counseling continued with making herbal pastries such as turmeric cakes, cinnamon egg rolls, and ginger nastar. The training on labeling and packaging as well as digital-based marketing practices. The outcomes of this community service project demonstrate that the Partner's knowledge about the variety of processed herbal pastries increased from 50% to 90%, the partner's skills in processing various herbal pastries rose from 55% to 80%, the capacity for comprehending and creating labels and food packaging also improved from 45% to 80% and knowledge and skills in digital marketing increased from 40% to 75%.
Presentation Dossier Stories of the São Francisco River: Subjects, Territories, and Temporalities
Authors: Santana Pedro Abelardo , Vieira da Cruz José
Published: December 2023

PresentationDossier Stories of the São Francisco River: Subjects, Territories, and Temporalities
Calcareous nannofossil biostratigraphy of the central Mediterranean Basin during the last 430,000 years
Authors: Incarbona Allesandro , Di Stefano Enrico , Bonomo Sergio
Published: December 2023

Quantitative analyses on over 2300 samples were carried ut on late Quaternary calcareous nannofossil assemblages from a central Mediterranean Sea sedimentary sequence (ODP Site 963A). Our results indicate that Emiliania huxleyi dominated the assemblages between 0 and 45.7 kyr BP; Gephyrocapsa muellerae between 45.7 and 177.3 kyr BP; small Gephyrocapsa between 177.3 and 263.5 kyr BP; Gephyrocapsa caribbeanica from 263.5 kyr BP down to the basal sample of our investigation, at about 430 kyr BP A comparison with similar reports from Atlantic Ocean sites indicates that the boundaries of the acme intervals identified in this study fall within the same Marine Isotopic Stages as the Atlantic Ocean sites, and their ages are strongly comparable The very high-resolution biostratigraphic framework obtained suggests that Mediterranean regional schemes might be improved using such an approach.
SÜRDÜRÜLEBİLİR PAZARLAMA YÖNELİMİ ÖLÇEĞİNİN KONAKLAMA İŞLETMELERİ ÜZERİNDE UYARLANMASI: YOZGAT İLİ ÖRNEĞİ
Authors: KARA Mehmet , KARAMAN Mesut , ÇELİKKAYA Kübra
Published: December 2023

Bu çalışmada konaklama işletmelerinde sürdürülebilir pazarlama yönelimi ölçeğinin Türkçe uyarlamasını gerçekleştirmektir. Sürdürülebilir pazarlama yöneliminin demografik değişkenlere göre değerlendirilmesi de çalışmanın alt amacıdır. Çalışmada veriler SPSS 26 ve AMOS 24 paket programları ile analiz edilmiştir. Verilerin değerlendirilmesinde tanımlayıcı istatistikler ve ölçek uyarlanması sürecinde psikometrik testlerden yararlanılmıştır. Katılımcıların %63,4’ü erkek, %73,2’si evlidir. Yapılan analizler neticesinde orijinal ölçekteki gibi üç alt boyutlu yapı AFA ve DFA neticesinde sağlanmıştır. Ölçeğin cronbach alpha değerleri yüksek düzeydedir. Sürdürülebilir pazarlama yönelimi kadınlara nazaran erkeklerde, 36-45 yaş dağılımlarında, lisans mezunlarında ve iş yeri sahibi/yönetici olanlarda anlamlı düzeyde daha yüksek olduğu ortaya çıkmıştır. Sonuç olarak, Sürdürülebilir Pazarlama Yönelimi Ölçeği’nin kullanılabilir bir ölçek olduğu gözlemlenmiştir.
The Pengaruh Produk dan Harga Terhadap Keputusan Pembelian Gula Semut
Authors: Fauziyah Rina Lestari , Rusti Nanda , Widakdo Danang SWPJ
Published: December 2023

The economic development of the community is currently increasing rapidly, one of which is the Banyuwangi Regency community. This is evidenced by the number of businesses that have sprung up to produce goods and services or similar products that have certain advantages and the existence of new developments in the field of communication and information technology such as internet networks, e-mail, marketplaces and others, making people more active in determining and deciding their needs. Businesses are competing to implement various marketing strategies to take advantage of market opportunities, by offering products that match the wants and needs of consumers. Based on this information, consumers make various choices and decide to buy, because product and price are things that determine consumer behavior when purchasing a product. This study aims to determine and analyze the effect of products and prices on purchasing decisions for ant sugar at CV. Latanza Banyuwangi. The sample was selected using simple random sampling and a sample of 30 respondents was obtained. Tests were carried out using multiple linear regression. The conclusion of this study shows that product and price have a partially or simultaneously have positive and significant effect on purchasing decisions. Price is the most important factor influencing purchasing decisions, because before making purchasing decisions consumers will consider the price first before considering the benefits received.
HUBUNGAN FAKTOR LINGKUNGAN TERHADAP PRODUKSI SERASAH MANGROVE TELING TOMBARIRI, TAMAN NASIONAL BUNAKEN
Authors: Langi Martina A. , Nurmawan Wawan
Published: December 2023

Penelitian ini bertujuan untuk membandingkan produktivitas ekosistem berdasarkan laju produksi serasah yang dikaitkan dengan jenis pohon dan parameter iklim di Mangrove Teling Tombariri, Taman Nasional Bunaken, Sulawesi Utara. Pengumpulan serasah dilakukan selama 12 bulan di tiga zona penyusun utama mangrove. Serasah kemudian dianalisis berdasarkan fraksi dan jenis. Produksi serasah kemudian dikorelasikan dengan curah hujan, suhu, dan kelembaban udara menggunakan koefisien korelasi sederhana. Korelasi linier antara produksi serasah bulanan fraksi daun, ranting, buah-bunga (fraksi reproduktif) dari setiap spesies mangrove dan parameter iklim bulanan (suhu, curah hujan, dan kelembaban) dihitung dengan menggunakan Korelasi Pearson p<0,01. Hasil menunjukkan bahwa laju produksi serasah di Mangrove Teling Tombariri Taman Nasional Bunaken didapatkan tertinggi pada jenis Sonneratia alba, diikuti oleh Rhizophora apiculata, dan terakhir Bruguiera gymnorhiza. Fraksi serasah terbesar adalah komponen daun, diikuti oleh ranting, dan komponen reproduktif (bunga dan buah), kecuali pada Sonneratia alba di mana fraksi komponen reproduktif lebih tinggi daripada komponen ranting. Selanjutnya faktor lingkungan yang menunjukkan korelasi paling kuat terhadap produksi serasah adalah curah hujan dan hal ini berlaku untuk ketiga jenis penyusun utama Mangrove Teling Tombariri.
The Effect of Problem-Based Learning Model Assisted by PhET Simulations on Students’ Physics Problem-Solving Abilities
Authors: Liana Liana , Kosim Kosim , Taufik Muhammad , Hikmawati Hikmawati
Published: December 2023

This study aims to examine the effect of problem-based learning model assisted by PhET simulations on students' physics problem solving ability. This research is Quasi Experimental with non-equivalent control group design. The population of this study were all students of class XI IPA SMAN 4 Mataram with sampling technique using purposive sampling technique, because there were four classes XI IPA, so it was determined that class XI IPA 1 as the experimental class and class XI IPA 2 as the control class. Based on the results of the study, the average value of physics problem solving ability of students in the experimental class was 45.09, while the average value of problem-solving ability of the control class was 39.61. Data Problem solving ability of both classes are normally distributed. Based on the results of the data homogeneity test, the problem-solving ability data are both homogeneous. Problem solving ability data was analyzed using the polled variance t-test and obtained a t_count of 2.24. The t-table value for problem solving ability data is 2.00 at a significant level of 5%. The value of t_count is greater than t_table, meaning that there is an effect of problem-based learning model assisted by PhET simulations on physics problem solving ability of students.