bluuebunny/crossref_metadata_2025 huggingface dataset:
The game-changing impact of POLE mutations in oncology—a review from a gynecologic oncology perspective
Authors: Kögl Johanna , Pan Teresa L. , Marth Christian , Zeimet Alain G.
Published: August 2024

Somatic mutations within the exonuclease proofreading domain (EDM) of the DNA polymerase Pol ϵ (POLE) gene are increasingly being discovered in ovarian, colorectal, urological, and, especially, endometrial carcinoma (EC), where these are found in up to 10% of the cases. In EC, there are five confirmed pathogenic somatic POLE-EDM mutations that are located at codons 286, 411, 297, 456, and 459, and these are called “hotspot” mutations. POLE mutant tumors are ultramutated entities with a frequency of base substitution mutations that is among the highest in human tumors. Interestingly, these mutations are associated with excellent clinical outcome in EC. An additional six “non-hotspot” POLE-EDM EC mutations are also considered pathogenic, and they also confer a favorable prognosis. Currently, de-escalation of adjuvant treatment is recommended for patients with EC with stage I–II tumors involving any of these 11 EDM mutations, even in patients with other clinicopathological risk factors. The high tumor mutational burden and the consequent increased infiltration of immune cells due to the overexpression of different neoantigens are probably responsible for the improved prognosis. Ongoing studies are examining POLE hotspot mutations among many non-gynecologic tumors, although the impact of such mutations on clinical outcomes is still a topic of debate. Therapeutic modalities for these hypermutated tumors are also an important consideration, including the need for or de-escalation of adjuvant treatments and the response to immune therapy. This review addresses the critical role of POLE mutations in gynecologic oncology and oncology in general, focusing on definitions, variants, underlying pathogenic mechanisms, upcoming developments in the field, and the clinic behavior associated with such mutations.
Pharmacological treatments for vascular dementia: a systematic review and Bayesian network meta-analysis
Authors: Dang Chun , Wang Qinxuan , Zhuang Yijia , Li Qian , Feng Li , Xiong Ying , Lu Yaoheng
Published: August 2024

Background

Vascular dementia (VaD) is one of the most prevalent, burdensome, and costly forms of dementia. Pharmacological treatment is often the first-line choice for clinicians; however, there is a paucity of comparative information regarding the multiple available drug options.

Methods and Analysis

A systematic review and network meta-analysis were conducted on randomized trials involving adult patients with VaD, sourced from PubMed, the Cochrane Library, EMBASE, Web of Science, OPENGREY, ClinicalTrials.gov, Wanfang Data, and CNKI. The primary outcomes included changes in Mini-Mental State Examination (MMSE) scores, activities of daily living (ADL) scores, and the incidence of adverse reactions. Efficacy and safety of intervention strategies were comprehensively analyzed using forest plots, cumulative ranking probability curves (SUCRA), and funnel plots, all generated with R software.

Results

A total of 194 RCTs comparing 21 different anti-VaD drugs with placebos or no treatment were analysed. Regarding MMSE scores, the five most effective drugs were Butylphthalide, Huperzine A, Edaravone, Rivastigmine, and Memantine. For ADL scores, the top five drugs in efficacy were Huperzine A, Butylphthalide, Tianzhi granule, Nicergoline, and Idebenone. In terms of the incidence of adverse drug reactions, Co-dergocrine Mesylate, Tongxinluo capsule, Butylphthalide, Piracetam, and Oxiracetam demonstrated favourable safety profiles.

Conclusion

This study enhances the understanding of the relative benefits and risks associated with various VaD treatments, providing a valuable reference for clinical decision-making.

Systematic Review Registration:

https://www.crd.york.ac.uk/PROSPERO/, identifier registration number.
Cynomorium songaricum Rupr. flavonoids improve cyclophosphamide-induced reproductive function damage by regulating the testosterone synthesis pathway
Authors: Chen Jiarong , Yang Xiaoyue , He Zhongmei , Chen Weijia , Zhao Yan , Li Jianming , Zong Ying , Du Rui
Published: August 2024

Introduction

The prevalence of male infertility has been increasing globally, necessitating the search for safe and nontoxic active compounds to alleviate reproductive dysfunction. Although the precise mechanism remains unknown, Cynomorium songaricum Rupr. (CS) extract has protective effects on the reproductive system. The effect of C. songaricum Rupr. flavonoids (CSF) on reproductive injury and testicular mesenchymal stem cell viability in male mice and TM3 cells was investigated.

Methods

We explored the possible association between these effects and the testosterone (T) synthesis pathway. Mice were administered cyclophosphamide to induce reproductive damage, followed by CSF administration. Body mass and organ index were recorded. Pathological changes in T and the epididymis were observed using hematoxylin-eosin staining. ELISA measured the serum levels of T, luteinizing hormone (LH), gonadotropin-releasing hormone (GnRH), follicle-stimulating hormone (FSH), and estradiol (E2) in mice. Fructose and zinc ion levels in the seminal plasma were measured. TM3 cells were treated with Bisphenol A (BPA) and different concentrations of CSF, followed by proliferative evaluations using the CCK-8 assay and T and LH level assessments using ELISA. Furthermore, the expression of steroidogenic enzyme genes and proteins was investigated using western blotting and RT-PCR.

Results

CSF exhibited a notable reduction in reproductive damage and improved pathological changes in testicular and epididymal tissues. CSF group demonstrated substantially higher levels of seminal plasma fructose and zinc ions; markedly elevated serum levels of T, LH, GnRH, and FSH; and lower levels of E2 than those of the model group. Intracellular T content and secretion of T and LH increase with CSF while effectively mitigating BPA-induced damage to TM3 cells. CSF group exhibited substantially higher gene and protein expression of steroidogenic enzymes than those of the model group, both in vivo and in vitro. CSF ameliorates reproductive impairment by enhancing the expression of pivotal enzymes involved in synthesizing T.

Discussion

CSF ameliorates cyclophosphamide-induced reproductive impairment and bisphenol A-induced TM3 cell damage in mice by regulating sex hormone levels in the Hypothalamic-Pituitary-Gonadal Axis (HPG axis) and upregulating the expression of steroidogenic enzymes. Therefore, CS is a potential treatment for male reproductive impairment.
Integrated GC-MS and UPLC-ESI-QTOF-MS based untargeted metabolomics analysis of in vitro raised tissues of Digitalis purpurea L
Authors: Bansal Yashika , Mujib A. , Mamgain Jyoti , Syeed Rukaya , Mohsin Mohammad , Nafees Afeefa , Dewir Yaser Hassan , Mendler-Drienyovszki Nóra
Published: August 2024

Digitalis purpurea L. is one of the important plant species of Nilgiris, Kashmir and Darjeeling regions of India, belonging to the family Plantaginaceae, with well-known pharmacological applications. In the present investigation, an in vitro culture technique of indirect shoot organogenesis of D. purpurea is being explored; the biochemical attributes, the antioxidant activities and the metabolomic analyses were made by utilizing untargeted Gas Chromatography-Mass Spectrometry (GC-MS) and Ultra Performance Liquid Chromatography coupled with electronspray ionization/quadrupole-time-of-flight-mass spectrometry (UPLC-ESI-QTOF-MS) approaches. Initially, the leaf explants were used for callus induction and proliferation and maximum callusing frequency (94.44%) and fresh biomass (4.9 g) were obtained on MS, fortified with 8.8 µM BAP (6-benzyl amino purine) + 0.9 µM 2,4-D (2,4-dichlorophenoxyacetic acid), subsequently shoot formation (indirect organogenesis) was noted on the same MS medium with a shoot induction frequency of 83.33%. Later on, the biochemical and antioxidant potential of in vivo-, in vitro grown leaf and leaf derived callus were assessed. Significantly higher total phenol, flavonoid, DPPH (2,2-diphenyl-1-picrylhydrazyl), POD (peroxidase) and SOD (superoxide dismutase) activities were noticed in in vitro grown callus and leaf tissues compared with field grown leaf. The GC-MS analysis of each methanolic extract (in vivo-, in vitro derived leaf and leaf derived callus) displayed the presence of more than 75 bioactive compounds viz loliolide, stigmasterin, alpha-tocopherol, squalene, palmitic acid, linoleic acid, beta-amyrin, campesterol etc. possessing immense therapeutic importance. The UPLC-MS based metabolite fingerprinting of each methanolic extracts were conducted in both positive and negative ionization mode. The obtained results revealed variation in phytochemical composition in field - and laboratory grown tissues, indicating the impact of in vitro culture conditions on plant tissues. The detected phytocompounds belongs to various classes such as flavonoids, steroids, terpenoids, carbohydrates, tannins, lignans etc. The medicinally important metabolites identified were 20, 22-dihydrodigoxigenin, digoxigenin monodigitoxoside, apigenin, luteolin, kaempferide, rosmarinic acid, nepitrin and others. The results of the present study suggest that in vitro culture of D. purpurea could successfully be utilized for the novel drug discovery by producing such important phytocompounds of commercial interest in shorter duration without harming the plants’ natural population.
Neuroactive hormones and personal growth: associations in Chilean adolescents (ages 12–25) with ovulatory dysfunction
Authors: del Río Juan Pablo , Tapia Valeska , Soto Hugo , Vigil Pilar
Published: August 2024

Introduction

Hormones produced by the hypothalamic–pituitary–adrenal-gonadal (HPAG) axis are crucial for modulating central nervous system (CNS) function and development throughout a person’s life. Disruptions in HPAG function can impact psychological development, particularly during adolescence—a period marked by psychological growth and the maturation of the HPAG axis. An early indicator of HPAG alterations is ovulatory dysfunction (OD), a common condition among adolescents.

Methods

This study explored the associations between neuroactive hormones and personal growth in adolescents with OD. Female participants aged 12–25 years with OD were recruited, and assessments were conducted to profile their basic hormonal levels and various dimensions of individual development, including self-concept clarity, sense of coherence, self-esteem, perfectionism, self-control, and mood states.

Results

Adolescents with OD (n = 117) had lower self-concept clarity and self-esteem compared to reference data. A significant portion of the sample displayed elevated levels of tension (71.25%), confusion (62.5%), fatigue (58.22%), and depression (52.6%). Self-esteem scores were negatively correlated with DHEAS (r = −0.224; p = 0.026) and glucose (r = −0.249; p = 0.010). Higher levels of free testosterone were associated with increased depression scores (coef = 0.2398; p = 0.002), whereas higher estradiol levels were linked to lower aggressiveness scores (coef = −0.0648; p = 0.001).

Discussion

These findings indicate that hormonal imbalances in adolescents with OD could affect personal growth. Further research is needed to establish causal relationships between the variables considered.
Circadian disturbances, anxiety and motor disturbances differentiate delirium superimposed on dementia from dementia-only
Authors: Schnorr Thiemo , Fleiner Tim , Trumpf Rieke , Prüter-Schwarte Christian , Fanselow Janina , Zijlstra Wiebren , Haussermann Peter
Published: August 2024

Background

To ensure adequate treatment, individuals with delirium superimposed on dementia (DSD) need to be differentiated reliably from those with dementia only (DO). Therefore, we aimed to examine the clinical indicators of DSD by assessing motor subtypes, cognitive performance and neuropsychiatric symptoms in DSD and DO patients.

Methods

Cross-sectional design with the Delirium-Motor-Subtyping Scale (DMSS), Mini-Mental-State-Examination (MMSE), Clock-Drawing-Test (CDT), DemTect, and Neuropsychiatric Inventory assessed after admission to an acute hospital.

Results

94 patients were included, 43 with DSD (78 ± 7 years, MMSE = 11 ± 9) and 51 with DO (79 ± 7 years, MMSE = 9 ± 8). DMSS “no subtype” was more common in the DO group (26% vs. 10%, p = .04). The DSD group showed lower CDT scores (DSD: M = 4 ± 3 vs. DO: M = 6 ± 1; p < .001) and higher anxiety (DSD: MED = 3 ± 8 vs. DO: MED = 3 ± 4; p = .01) and sleep/night-time behavior disturbances (DSD: MED = 0 ± 6 vs. DO: MED = 0 ± 0; p = .02).

Conclusions

Sleep/night-time behavior disturbances appear to be a clinical indicator of DSD. Motor subtypes can identify cases at increased risk of developing delirium or unrecognized delirium.

Clinical trial registration

https://drks.de/search/de/trial/DRKS00025439, identifier DRKS00025439.
A narrative review of the CEPH-accredited bachelor’s public health programs’ curricula in the United States
Authors: Kedia Satish K. , Entwistle Coree , Magaña Laura , Seward Tracie G. , Joshi Ashish
Published: August 2024

Background

Undergraduate programs in public health are becoming increasingly popular in the United States (US). The recent pandemic, growing climate instability, and the aging baby boomers have led to higher demands for skilled public health professionals at various levels of the workforce. This study examines the nature of courses being delivered in undergraduate public health programs across the United States. The goal is to assess domains, themes, competencies, and other specialized skills that are currently covered in these academic programs.

Methodology

A search was conducted in February 2023 using the online CEPH program database to identify undergraduate public health programs in the US. In total, 86 institutions and 90 CEPH-accredited undergraduate public health programs were identified. Lists of public health courses were retrieved from each program, and a total of 2,259 unduplicated courses were extracted and analyzed. A content analysis of the extracted topics was conducted to generate 38 common themes among the courses offered. Coded course themes were mapped to the public health domains and competencies listed by the ASPPH and CEPH to evaluate the distribution of themes across course offerings.

Results

Analysis of course themes found that Foundations of Public Health, Epidemiology, Public Health Management, Policy, and Leadership, Climate and Environmental Health, and Global Health Issues were the most prevalent. When course themes were mapped onto the ASPPH and CEPH domains of critical public health learning, “overview of public health” and “determinants of health” were the most populated domains. Programs had different emphases according to their approach, but overall, about two-thirds of course themes were focused on foundational and theoretical concepts of public health, and one-third were directed toward practical applications of public health concepts.

Conclusion

As the demand for skilled public health workers continues to rise, programs will need to watch the skills and competencies required in the current working environment, as well as the ASPPH and CEPH criteria, and adjust their approach accordingly. Given the rapid changes in the public health landscape, schools and programs of public health should evaluate their curricula to ensure that they are meeting the needs of the workforce and the world.
Prevalence and associated risk factors for depression symptoms in adolescent girls with polycystic ovary syndrome: a hospital-based cross-sectional study
Authors: Wang Lianhong , Su Sihui , Xiong Tingting , Wang Meili , Ding Rui , Tan Huiwen , Zhu Minglan
Published: August 2024

Background

Depression symptoms are a growing concern for adolescent girls with PCOS around the world. However, relatively small samples have given varying reports of its prevalence and risk factors in previous studies. Therefore, there is an urgent need for further research on the prevalence and associated factors of depression among adolescent girls with PCOS.

Methods

A cross-sectional study was performed from October 2021 to May 2022 using a questionnaire and examination of the medical records of a convenience sample of 335 adolescent girls with PCOS. The Chinese version of the Children’s Depression Scale (CDI) was used to investigate depression symptoms. A multivariate logistic regression model was used to determine factors that were significantly associated with depression symptoms.

Results

The prevalence of depression symptoms was 36.12% among adolescent girls with PCOS. A multivariate logistic regression model identified significant factors as perceived social support (95% CI: 0.921 ~ 0.965%, p = 0.000), sleep quality (95% CI: 1.134 ~ 1.324%, p = 0.000), belief illness (95% CI, 1.040 ~ 1.102%, p = 0.000), hirsutism (95% CI, 1.292 ~ 4.392%, p = 0.005), and LH/FSH ≥ 2 (95% CI, 1.939 ~ 6.369%, p = 0.000).

Conclusion

Depression symptoms are an important problem among adolescent girls with PCOS in China. A comprehensive approach that encompasses social support, structured health education for the disease, and evaluation of the psychological status of PCOS girls with hirsutism (and) or LH/FSH ≥ 2 in time is important to minimize depression symptoms and improve psychological health among adolescent girls with PCOS.
Longitudinal trends and correlation between autism spectrum disorder prevalence and sperm quality parameters (2000–2024): a comprehensive statistical analysis
Authors: Al-Salihy Adil Abdul-Rehman Siddiq
Published: August 2024

Introduction

Over the past few decades, there has been growing concern about the concurrent trends of increasing Autism Spectrum Disorder (ASD) prevalence and declining sperm quality. These trends represent significant public health challenges that warrant thorough investigation of their underlying causes and implications.

Objectives

The primary objectives of this study are to analyze trends in ASD prevalence and sperm quality parameters from 2000 to 2024, assess the statistical significance and effect size of these trends, explore potential correlations between ASD prevalence and sperm quality parameters, and identify significant predictors among sperm quality parameters that influence ASD prevalence.

Methods

This study employed a longitudinal approach using multiple regression, time series analysis, ANOVA, Principal Component Analysis (PCA), hierarchical clustering, logistic regression, and cross-correlation analysis. Data on ASD prevalence were sourced from the CDC Autism and Developmental Disabilities Monitoring Network, while sperm quality data were collected from various published studies.

Results

The findings reveal significant negative associations between ASD prevalence and sperm quality parameters such as sperm concentration and motility, suggesting that better sperm quality is linked to lower ASD rates. Conversely, parameters like sperm DNA fragmentation (SDF), volume of ejaculate, pH level, and semen viscosity show positive associations with ASD prevalence, indicating higher values in these parameters correlate with higher ASD rates.

Conclusion

The study highlights the importance of maintaining reproductive health to potentially mitigate ASD risk and calls for further research to elucidate the underlying mechanisms driving these trends. These findings support the hypothesis that reproductive health factors play a crucial role in ASD etiology and suggest potential biological markers for assessing ASD risk.
Facilitating the high-quality agricultural development with digital economy: a panel data study of Jiangsu Province from 2013 to 2021
Authors: Ma Xiaoxu , Lv Lianzhou
Published: August 2024

Agricultural modernization can only be attained through the high-quality development of agriculture, which is made possible by the deep integration of the digital economy with traditional agriculture. From the perspective of the entire agricultural industry chain, this paper offers a theoretical and empirical examination of the digital economy’s role in enabling high-quality agricultural development. The fixed effects model, convergence test, threshold model, and spatial error model were implemented based on the panel data of 13 cities in Jiangsu Province from 2013 to 2021 to validate the role of the digital economy in enabling high-quality agricultural development. The findings indicated that first, for every 1% increased in the level of digital economy development, the level of high-quality agricultural development increased by approximately 0.183%. Second, the high-quality development of agriculture had the characteristics of absolute convergence and conditional convergence, and there was a non-linear character in the role of the digital economy in the high-quality agricultural development. Third, for every 1% increase in the development level of digital inclusive finance, the level of high-quality agricultural development in surrounding areas with similar economic levels will be improved by about 0.188%.In this regard, Jiangsu Province should grasp the opportunity of the era of digital economic development, continue to strengthen the construction of digital economic development in backward areas, and attach great importance to inter-regional exchanges and cooperation in the construction of digital agriculture.
Investigando as Empresas Circulares
Authors: Carreira Rui Jorge , Ferreira José Vasconcelos , Ramos Ana Luisa
Published: August 2024

Face ao problema de escassez de recursos virgens e ao problema do crescente exponencial de excesso de resíduos, a transição da economia linear para a economia circular afigura-se como a solução cada vez mais defendida para tentar atenuar estes problemas. A forma como cada país e líder de empresa lida com esta realidade é bastante divergente. Em particular, pretende-se averiguar como é que as PME’s portuguesas se posicionam face à EC. Com base na Grounded Theory, optou-se pelo recurso a entrevistas semiestruturadas. Dependendo o sucesso das mesmas do guião utilizado, apresenta-se o processo seguido para o concretizar, o qual envolveu 4 empresas selecionadas por conveniência.
Utilização do geoprocessamento no estudo do estado da conservação da arborização urbana: Estudo de Caso bairro do Alto Maé B - Cidade de Maputo
Authors: Mandala Sabil Damião , Sitoe Dércia Enoque , Uiliamo Eza Bento
Published: August 2024

Esta pesquisa visa fazer o levantamento do estado de conservação da arborização urbana no bairro Alto Maé B, para encontrar formas de reverter o cenário de degradação do parque arbóreo de Maputo e de consciencialização dos munícipes na conservação ambiental, no aspecto arbóreo da Cidade. O trabalho apoiou-se em da pesquisa bibliográfica, observação directa, e no método cartográfico. O resultado aponta um total de 962 observações de lugares, ao longo das avenidas, nomeadamente com: Acácias Amarelas, Acácias Vermelhas, Maçaniqueiras, Amêndoeiras, Palmeiras, Espaços Vazios (árvores mortas, ou cortadas e áreas tampadas por betão). Recomenda-se a reposição de árvores mortas e a consciencialização dos munícipes no cuidado com as plantas; a implementação da legislação existente, evitando substituição de acácias utilizadas na ornamentação inicial das avenidas ou ruas.
Vörösmarty Mihály elfeledett grammatikájának nyomában. A Kurzgefaßte ungrische Sprachlehre és az összevető nyelvtanítási szemlélet
Authors: Nagy Dóra
Published: August 2024

Mihály Vörösmarty is known primarily as one of the greatest poets of the Hungarian Reform Era. In addition to his outstanding literary achievements, the significance of his linguistic works should likewise be remembered. After reviewing Vörösmarty’s contributions to the field of linguistics and the nature of his relationship to the German language, I will discuss some notable comparative comments from his grammar Kurzgefaßte ungrische Sprachlehre für Deutsche. Nebst einer Auswahl deutsch-ungrischer Uebungsstücke (1832). The aim of the analysis is to gain a deeper insight into an important period in the history of Hungarian language textbook writing.
A Survey on User Experience of Blockchain Transactions: Security and Adaptability Issues
Authors: Handayani Indri , Apriani Desy , Mulyati Mulyati , Aprila Yusuf Natasya , Rahmania Az Zahra Achani
Published: August 2024

Blockchain technology has become a major focus of digital change in recent years. Initially known as the infrastructure that supports digital currencies, blockchain now has enormous potential in improving user experience across a wide range of sectors. The application of this technology is capable of addressing a variety of issues that exist in the industry, including issues of trust, transparency, security, and reliability of data processing. In this paper, we will explore various applications of blockchain technology that aim to improve user experience in transactions. We will explain the concept of blockchain technology, analyze its advantages and disadvantages, and identify factors that affect its success or obstacles that may arise during implementation. By understanding the potential of blockchain technology and its applications that can improve user experience in transactions, we can pave the way for further progress in providing more secure, efficient, and transparent solutions for transaction activities in the future. The methodology employed in this study involves conducting a survey through online questionnaires that were distributed to individuals knowledgeable about the concept of blockchain technology with a total sample size of 96 people. The analysis approach used is Smart PLS. Thus, this research is expected to provide a deeper insight into the application of blockchain technology to improve user experience in transactions.
Logistics Business Model Strategies in Facing Changes in Big Data and Blockchain Technology: A Business Model Canvas Approach
Authors: Natalie Septiani  , Alice Angelina Bitsy  , Oscar Jayanagara
Published: August 2024

Currently, the world is undergoing a transformation towards the era of digitization and automation, which serves as a key element in business competition strategies, including in the logistics sector. The use of data for organizational decision-making has become an integral part of digitization and automation. Big Data and Blockchain technologies are now being applied in various business sectors to enhance the efficiency of business processes and impact business models, creating new transformations that align with global business developments. These changes are analyzed both internally and externally using the Business Model Canvas (BMC). A SWOT analysis of the changes in the business model is necessary to provide a detailed depiction of the new business processes. The results of the analysis indicate that: first, technological advancements, especially in Big Data and Blockchain, continue to disrupt businesses to improve optimal performance; second, the implementation of Big Data and Blockchain results in both internal and external changes related to intra- and inter-organizational relationships; third, a SWOT analysis can detail the advantages of Big Data and Blockchain technologies in the business sector, particularly in logistics.
Implementation Of The Use Of Artificial Intelligence In Higher Education
Authors: Abigail Leffia  , Alexander Chou Kiboyi  , Rizky Fredrin Terizla
Published: August 2024

Higher education is currently undergoing significant digital transformation, with artificial intelligence (AI) emerging as a key innovation shaping this change. This research elaborates on the implementation and impact of AI in the context of higher education. The discussion encompasses the influence of AI on the learning process, improvements in administrative efficiency, and shifts in the education paradigm. The research also explores specific AI applications, such as adaptive learning, sentiment analysis, and data management, which substantially enrich student learning experiences and support decision-making in higher education institutions. While the benefits are substantial, the research also highlights challenges and issues that may arise, including privacy concerns, data security, and the integration of technology into academic curricula. In conclusion, the implementation of artificial intelligence in higher education has the potential to be a cornerstone in shaping students who are prepared for the demands of knowledge-based societies and contributing to the development of a more adaptive and innovative education system.
SCIENTIFIC COMMENTS ABOUT SEEDING RATE OF SPRING WHEAT IN TRANSBAIKALIA
Authors: Батудаев Антон Прокопьевич , Коршунов Василий Михайлович , Цыдыпов Булат Содномович , Кушнарев Анатолий Григорьевич , Гребенщикова Тамара Васильевна
Published: August 2024

В данной статье представлены краткие научные суждения о норме высева яровой пшеницы в земледельческих зонах Западного (Республика Бурятия) и Восточного Забайкалья (Забайкальский край). Рассмотрены нормы высева яровой пшеницы и их влияние на формирование урожая в разных почвенно-климатических условиях. Показаны результаты научных исследований этого вопроса и научные рекомендации в ряде регионов Сибири и приведены мнения ученых об особенностях роста и развития яровой пшеницы при тех или иных нормах высева. При анализе становится очевидным, что до сегодняшнего времени и не во всех земледельческих регионах Сибири четко установлены научно обоснованные нормы высева яровой пшеницы. К тому же показано, что нормы высева напрямую зависят от многих факторов: складывающихся погодных условий вегетационных периодов, сортового набора, типа почвы и т.д. При этом надо принимать во внимание и техническую оснащенность, особенно сельскохозяйственной техникой нового поколения, чтобы рационально сочетать использование как традиционных, так и новых почвообрабатывающих орудий и посевных комплексов с учетом предшественников и окультуренности почвы.

The given article provides brief scientific assertions concerning the rate of seeding of the spring wheat in the agricultural regions of the Western part (the Republic of Buryatia) and the Eastern part (the Zabaikalsky krai) of the Transbaikalia. The article studies the rate of seeding of the spring wheat and its influence on the harvest development under the different soil and climatic conditions. The article provides the results of scientific researches of this issue and scientific advices in the several Siberian regions. Also, it gives some scientific opinions concerning peculiarities of growth and development of the spring wheat under any given rate of seeding. After the analysis, it was found out that even nowadays some Siberian regions have no clearly and scientifically defined rate of seeding of the spring wheat. The article shows that the rate of seeding of the spring wheat is directly dependent on various factors, among which the weather conditions during the vegetation season, selection of cultivars, types of soil, etc. One more important factor that should be taken into consideration is the usage of technical equipment, especially the modern one. This will allow to combine efficiently both traditional and new soil-tilling and planting units considering forecrops and cultivation of soil.
ORGANOGENESIS OF HALF-HIGHBUSH BLUEBERRY PLANTS DEPENDING ON GROWTH-REGULATING SUBSTANCES AT CLONAL MICROPROPAGATION
Authors: Макаров Сергей Сергеевич , Кузнецова Ирина Борисовна , Куликова Елена Ивановна
Published: August 2024

В статье приведены результаты исследований по изучению влияния регуляторов роста цитокининовой и ауксиновой групп в различных концентрациях на биометрические показатели роста растений голубики полувысокорослой сорта Northblue и перспективной гибридной формы 23-1-11. Голубика полувысокорослая - малотребовательное к теплообеспеченности вегетационного периода и морозостойкое растение с высокой пищевой и лекарственной ценностью. Для создания плантаций лесных ягодных растений рода Vaccinium с целью рекультивации выработанных торфяных месторождений наиболее целесообразно использовать метод клонального микроразмножения. На этапе «собственно микроразмножение» наибольшая суммарная длина микропобегов (23,7 см) голубики полувысокой отмечена при концентрации цитокинина 2ip 3,0 мг/л в питательной среде WPM, а наибольшее количество микропобегов (5,8 шт.) - при концентрации 5,0 мг/л. На этапе «укоренение in vitro» наибольшая суммарная длина корней (12,1 см) голубики выявлена при концентрации ауксина ИУК 1,0 мг/л в питательной среде WPM, а максимальное количество корней (5,4 шт.) - при концентрации 2,0 мг/л. Гибридная форма 23-1-11 голубики полувысокорослой отличалась большей суммарной длиной микропобегов и корней по сравнению с растениями сорта Northblue.

The results of studies on the effect of growth regulators of the cytokinin and auxin groups in various concentrations on the biometric growth parameters of half-highbush blueberry plants of Northblue cultivar and the promising hybrid form 23-1-11. Galf-highbush blueberry is not very demanding in terms of heat supply during the growing season and is a frost-resistant plant with high nutritional and medicinal value. Clonal micropropagation is most expedient method to use for creation the plantations of forest berry plants of Vaccinium genus for the purpose of reclamation of depleted peat deposits. The greatest total length of microshoots (23.7 cm) of half-highbush blueberry is noted at a concentration of 2ip cytokinin 3.0 mg/l in the WPM nutrient medium at the stage “proper micropropagation”, and the greatest number of microshoots (5.8 pcs.) is at a concentration of 5.0 mg/l. The greatest total length of roots (12.1 cm) of blueberry is detected at a concentration of auxin IAA of 1.0 mg/l in the WPM nutrient medium at the stage of “rooting in vitro”, and the maximum number of roots (5.4 pcs.) is at a concentration of 2,0 mg/l. The hybrid form 23-1-11 of half-highbush blueberry have a greater total length of microshoots and roots than plants of the Northblue cultivar.
HEMATOLOGICAL INDICATORS OF SPECIALIZED MEAT BREEDS ACCORDING TO THE SEASONS OF THE YEAR
Authors: Гармаев Баир Дылгырович , Толочка Василий Васильевич , Косилов Владимир Иванович , Гармаев Дылгыр Цыдыпович , Доржиев Сергей Жаргалович
Published: August 2024

В работе представлены результаты изучения морфологического, азотного и минерального состава крови бычков специализированных мясных пород: I группа калмыцкой породы, II - абердин-ангусской, III - герефордской. Целью исследования являлось изучение содержания в крови эритроцитов, гемоглобина, лейкоцитов в сыворотке крови - общего и остаточного азота, кальция, фосфора, витамина А и определение кислотной емкости. При проведении экспериментальной части работы бычки подопытных групп находились в аналогичных условиях кормления и содержания. Установлено влияние сезона года на морфологический состав крови. При этом в летний период по сравнению с зимним у бычков подопытных групп количество эритроцитов в крови повысилось на 11,08-12,42%, содержание гемоглобина - на 7,65-9,03% при снижении количества лейкоцитов. При этом лидирующее положение по количеству эритроцитов и содержанию гемоглобина занимали бычки абердин-ангусской и герефордской пород. В летний период они превосходили молодняк калмыцкой породы по величине первого показателя на 6,73-10,60%. Аналогичные тенденции отмечены по содержанию общего и остаточного азота в сыворотке крови, фосфора, кислотной емкости и содержанию витамина А. В то же время концентрация кальция в летний сезон по сравнению с зимним периодом снизилась.

The article presents the results of studying the morphological, nitrogen and mineral composition of the blood of bulls of specialized meat breeds: the I group is of the Kalmyk breed, the II - of Aberdeen-Angus, the III - of Hereford. The aim of the research work was to study the amount of erythrocytes, hemoglobin, leukocytes in blood serum - total and residual nitrogen, calcium, phosphorus, vitamin A and to determine acid capacity. During the research, the bulls of the experimental groups were in similar feeding and keeping conditions. The influence of the season of the year on the morphological composition of blood was determined. At the same time, in the summer period, in the bulls of the experimental groups, the number of erythrocytes in the blood increased by 11.08-12.42% in comparison to the winter period, the hemoglobin content - by 7.65-9.03% with a decrease amount of leukocytes. Leading position in terms of the number of erythrocytes and hemoglobin content was occupied by bulls of the Aberdeen-Angus and Hereford breeds. In the summer period, they surpassed the young of the Kalmyk breed in terms of the value of the first indicator by 6.73-10.60%. Similar trends were noted for the content of total and residual nitrogen in the blood serum, phosphorus, acid capacity and vitamin A content. At the same time, the concentration of calcium in the summer season decreased compared to the winter period.
El Canto de Orfeo… Motivación, reflexión e innovación en torno a la planificación docente
Authors: Perrupato Sebastián
Published: August 2024

La programación de la enseñanza es un tema por demás controvertido en la producción académica sobre la didáctica. En los últimos años, ha venido cobrando relevancia la idea de que la misma no presenta más que limitaciones en la tarea docente. Sin embargo, las investigaciones demuestran que la clase tiene sus orígenes en una idea primigenia que contribuye y potencia las posibilidades para el aprendizaje.
El presente trabajo pretende abordar la planificación como espacio de interrogantes iniciales sobre los cuales comenzar a pensar la clase. Para hacerlo se realiza una investigación hermenéutico-interpretativa con un diseño flexible a partir de tres instrumentos fundamentales: encuestas a estudiantes y docentes, entrevistas en profundidad y observaciones áulicas que se complementan con el análisis de Programas de Trabajo Docente.
Los resultados a los que se arriba ponen de relevancia la potencialidad de la planificación en el diseño de clases, no desde lo prescriptivo, sino desde la generación de un espacio de preguntas que abre la posibilidad de crear una clase atractiva. Un punto de partida desde donde comenzar a habitar una clase capaz de eclipsar los cantos de sirena e invitar a los estudiantes a fundar compromisos en la construcción de saberes.
ANÁLISE DOS IMPACTOS SOCIOAMBIENTAIS DECORRENTE DA INSTALAÇÃO DE NOVOS EMPREENDIMENTOS NO BAIRRO ANGELIM EM TERESINA/PI
Authors: Sousa Marcos Gomes de , Monte Lucas Almeida , Viana Bartira Araujo da Silva
Published: August 2024

A pesquisa realizada na cidade de Teresina-PI tem como objeto de estudo transformações originadas da instalação de novos empreendimentos no bairro Angelim durante a pandemia da Covid-19. Diante disso, tem-se como objetivo geral investigar os impactos socioambientais da implantação de novos empreendimentos no bairro Angelim, destacando a atuação dos agentes transformadores do espaço e da paisagem. Ademais, têm-se como objetivos específicos identificar os empreendimentos instalados no bairro Angelim, no período de pandemia, nos anos de 2020 a 2022 e descrever o cenário atual relacionado aos impactos socioambientais do bairro Angelim devido a instalação de empreendimentos do ramo industrial. Utilizou-se de leituras em livros, artigos científicos, dissertações de mestrado, teses de doutorado e visitas em sites especializados acerca do tema em questão, tendo como autores norteadores Lima (2002); Rodrigues (2007); Castro, Gomes e Corrêa (2018) e Corrêa (1994). Conclui-se, portanto, que ocorreram transformações espaciais originados da instalação em áreas verdes do bairro, a saber, no setor logístico (Empresa J&T Express-SC), serviços (Loja de Conveniência) e alimentício (Empresa ServCozinha).  Com isso têm-se os seguintes impactos ambientais negativos: uso inadequado do solo, com a horizontalização e verticalização das edificações ocorrendo de forma desordenada; a retirada da cobertura vegetal decorrente da expansão urbana e do aumento populacional e a expulsão e/ou extinção de espécies animais nativas dessa região.
Ownership Status of Land Rights from Reclamation Results by Foreign Legal Subject
Authors: Suganda Yosua Simon
Published: August 2024

Rapid population growth that did not accompany by an increase of land area can lead to a big problem in a long term, such as high land prices. Hence reclamation need to be done so it can help people to have a land with affordable price. However, reclamation can’t be done without following terms and conditions by the government. This writing made so we can know who is eligible to do the reclamation, what type of law subject can do reclamation. The writings use normative-juridicial research approach and qualitative-juridicial analysis method. By following all legal requirements person and entities law subject can do the reclamation, both local and foreign legal subject.
Comparison of Islamic Law and Human Rights; Navigating Consensus of LGBT in Thailand
Authors: Fitriyah Aidatul , Alauddin Muhammad Badat
Published: August 2024

This research aims to examine the dynamics of law and human rights (HAM) related to the LGBT community in Thailand, with a focus on analysing the concept of Islamic epistemology on the social status impact of the idea of gender division in Thailand, theological and juridical comparison of human rights in accommodating LGBT, as well as challenges and efforts to harmonise Islamic law and human rights towards LGBT groups in Thailand. The methodology used is a qualitative approach involving normative and comparative legal analysis. The researcher collected a literature review of secondary data from relevant sources, including scholarly works, books, and legal documents. The results showed significant contradictions between Thailand's more inclusive concept of gender division and the binary nature of Islamic law. The research also uncovered Islamic theological underpinnings against LGBT and compared them with juridical approaches that protect LGBT human rights. It also explores the reconciliation process between Islamic law and human rights in accommodating LGBT through dialogue and stakeholder cooperation. From this research, it can be concluded that LGBT law and human rights tolerance involve a complexity of legal views, religious values, and human rights principles, reflecting ongoing challenges and debates within society and the legal system.
Growth orientation control in rapid solid-state crystal growth of (K,Na)NbO3 single crystals using plate-like NaNbO3 single crystal particles
Authors: Osaka Hiromi , Morimoto Takaaki , Ishii Keisuke
Published: August 2024

The rolling-extended orientation technique and plate-like NaNbO3 (NN) single crystal particles prepared by a single-step molten salt synthesis, both of which have been developed to fabricate (K, Na)NbO3 (KNN) textured ceramics, were utilized to control the growth orientation of KNN single crystals synthesized by a rapid solid-stated crystal growth (RSSCG) method. As the seed crystals, two kinds of NN single crystal particles were synthesized using pure NaCl and KCl-NaCl mixed molten salts. Plate-like KNN single crystals of about 1 cm squares with the upper and lower faces almost parallel to the (100) (001) planes were obtained with a probability exceeding 50% when NN single crystal particles were synthesized from mixed salts and were subsequently thermal-treated again in Na2CO3-NaCl mixed molten salts under appropriate conditions to remove the Bi element, which is known as the suppression factor of the crystal growth. The average crystal growth rate was 0.6–1.2 mm h−1. Controlling the growth orientation of KNN single crystals produced by the SSCG method using seed crystals other than KTaO3 single crystals was successfully accomplished for the first time.
Strategi Pemberdayaan UMKM di Kabupaten Agam
Authors: Mansur Yuwarman
Published: August 2024

This study describes the Strategy for Empowering Micro, Small, and Medium Enterprises (MSMEs) conducted by the Agam Regency Government through the Office of Cooperatives, Micro and Small and Medium Enterprises, Industry, and Trade. This is motivated by the existence of empowerment programs included in two patterns, namely the pattern of empowering development and empowerment patterns of assistance in efforts to enable MSMEs in Agam Regency. Researchers then compare what happens to business actors. Providing capital assistance, training, mentoring activities, and product promotion significantly empowers MSMEs in Agam Regency. In addition, the empowerment program carried out by the Agam Regency Government through the Office of Cooperatives, Micro and Small and Medium Enterprises, Industry, and Trade is in the form of the establishment of a business-owned business entity, providing a business gallery of business production, launching E-UMKM applications, formation of forums MSMEs, establish business partnerships and market expansion. The research method used is descriptive qualitative, providing an objective picture or explanation related to the empowerment of MSMEs by the Agam Regency Government. The results of this study indicate that the empowerment of MSMEs in Agam Regency in the form of programs included in the pattern of guidance and assistance has been effective and beneficial for business actors.
The Impact of Promotional Strategies on Customer Decisions to Save at PT Bank Sumut KCP USU
Authors: Sebayang Immanuel Edy Suranta
Published: August 2024

This research examines how PT Bank Sumut KCP USU's promotion strategy affects customers' decisions to save. The study's population consists of 12,650 customers of PT Bank Sumut KCP USU. Using the Slovin formula, 100 participants were selected for the sample. The data analysis approach employed multiple linear regression analysis, including statistical tests (F, T, and determination coefficient) and tests for classical assumptions (normality, multicollinearity, autocorrelation, and heteroscedasticity). The normalcy test using Kolmogorov-Smirnov found that the data distribution is normal. There were no signs of heteroscedasticity, autocorrelation, or multicollinearity. The regression analysis revealed a partially positive and significant influence from advertising and direct marketing, and a partially positive but non-significant effect from sales promotion, public relations, and personal sales. An R-squared value of 0.488 indicates that the independent variables explain 48.8% of the variance in the dependent variable, with the remaining 51.2% attributed to factors not included in the regression model
Vocabulary-Based Computer Assisted Language Learning (CALL)
Authors: Irani Z Ulfah , Maulana Riyan
Published: August 2024

This research aims to explore the implementation of Computer-Assisted Language Learning (CALL) in vocabulary instruction and its impact on students' vocabulary proficiency. The study employs a descriptive qualitative research design, utilizing purposive sampling to select participants. Data collection methods included questionnaires, observations, and documentary analysis to gather comprehensive insights into the effectiveness of CALL in the classroom. The findings reveal that CALL significantly enhances student achievement, with 86% of the students scoring within the excellent to good range in vocabulary assessments. The integration of computers in the learning process has been shown to positively influence vocabulary acquisition, making it a valuable tool in language education. Additionally, the use of CALL has been found to increase student motivation. The interactive elements provided by CALL, such as sounds, images, animations, and colors, contribute to making the learning experience more engaging and appealing for young learners. Consequently, CALL emerges as an effective method for both improving vocabulary skills and enhancing student engagement in language learning.