Prolonged distal motor latency of median nerve does not improve diagnostic accuracy for CIDP
Authors: Spina Emanuele , Doneddu Pietro Emiliano , Liberatore Giuseppe , Cocito Dario , Fazio Raffaella , Briani Chiara , Filosto Massimiliano , Benedetti Luana , Antonini Giovanni , Cosentino Giuseppe , Jann Stefano , Mazzeo Anna , Cortese Andrea , Marfia Girolama Alessandra , Clerici Angelo Maurizio , Siciliano Gabriele , Carpo Marinella , Luigetti Marco , Lauria Giuseppe , Rosso Tiziana , Cavaletti Guido , Peci Erdita , Tronci Stefano , Ruiz Marta , Piccinelli Stefano Cotti , Schenone Angelo , Leonardi Luca , Gentile Luca , Piccolo Laura , Mataluni Giorgia , Santoro Lucio , Nobile-Orazio Eduardo , Manganelli Fiore ,   The Italian CIDP Database Study Group, Doneddu Pietro Emiliano , Liberatore Giuseppe , Gallia Francesca , Nobile-Orazio Eduardo , Rozzano  , Peci Erdita , Cocito Dario , Tronci Stefano , Fazio Raffaella , Raffaele San , Manganelli Fiore , Santoro Lucio , Spina Emanuele , Pisano Enrica , Ruiz Marta , Briani Chiara , Piccinelli Stefano Cotti , Filosto Massimiliano , Beronio Alessandro , Benedetti Luana , Toscano Antonio , Gentile Luca , Mazzeo Anna , Mataluni Giorgia , Marfia Girolama Alessandra , Piccolo Laura , Vegezzi Elisa , Cortese Andrea , Cosentino Giuseppe , Fierro Brigida , Pinuccia Verrengia Elena , Jann Stefano , Bianchi Elisa , Beghi Ettore , Clerici Angelo Maurizio , Scrascia Federica , Carpo Marinella , Garnero Martina , Schenone Angelo , Luigetti Marco , Sabatelli Mario , Dacci Patrizia , Lauria Giuseppe , Leonardi Luca , Antonini Giovanni , Rosso Tiziana , Schirinziand Rika , Siciliano Gabriele , Balducci Claudia , Cavaletti Guido 
Published: June 2021

Compression of the median nerve at the carpal tunnel can give demyelinating features and result in distal motor latency (DML) prolongation fulfilling the EFNS/PNS demyelinating criteria for chronic inflammatory demyelinating polyneuropathy (CIDP). Accordingly, being carpal tunnel syndrome (CTS) common in the general population, the EFNS/PNS guidelines recommend excluding the DML of the median nerve when DML prolongation may be consistent with median neuropathy at the wrist from CTS. The main aims of this study were to verify whether the inclusion of DML of the median nerve (when consistent with CTS) could improve electrophysiological diagnostic accuracy for CIDP and if the median nerve at the carpal tunnel was more prone to demyelination. We analyzed electrophysiological data from 499 patients included consecutively into the Italian CIDP Database. According to the EFNS/PNS criteria, 352 patients had a definite, 10 a probable, and 57 a possible diagnosis of CIDP, while 80 were not fulfilling the diagnostic criteria. The inclusion of DML prolongation of median nerve did not improve significantly the diagnostic accuracy for CIDP; overall diagnostic class changed in 6 out of 499 patients (1.2%) and electrodiagnostic class of CIDP changed from not fulfilling to possible in only 2 patients (2.5% of not-fulfilling patients). In conclusion, we can infer that excluding DML prolongation of median nerve does not increase the risk of missing a diagnosis of CIDP thus corroborating the current EFNS/PNS criteria.