bluuebunny/crossref_metadata_2025 huggingface dataset:
Result Analysis of BRAF V600E Gene Mutation Using Molecular and Immunohistochemistry Detection in Acral Malignant Melanoma
Authors: Aminah Usman Hermin , Hernowo Bethy S , Lumbantobing Maringan Diapari , Hindritiani Reti
Published: August 2019

Background and Objective: Detection of BRAF V¬600E gene mutation in Malignant Melanoma (MM) is essential in offering anti BRAF targeted therapy for MM patients. Expression of BRAF V600E mutant protein detected using immunohistochemistry (IHC) is affordable, rapid, and reliable. This study aimed to measure the sensitivity and specificity of IHC compared to BRAFV 600E immunoexpression by molecular detection.Method: This study used a paraffin block of acral MM patients to analyze BRAF V600E mutation status using anti-BRAF V600E IHC compared to Real-Time Polymerase Chain Reaction (RT PCR) which is a gold standard.Result: In total, ninety-six samples were tested using IHC and RT-PCR. RT-PCR showed that 15 (15.6%) samples were positive for BRAF V600E mutation. The sensitivity and specificity for IHC were 73.3% and 87.6% respectively. Concordance value of IHC was 85.4%. There were 10 false positives and 4 false negatives. IHC staining may be applied as early detection of BRAFV600E mutation in MM patients that are going to receive anti BRAF targeted therapy.
Silent High Grade Cervical Intraepithelial Neoplasia Diagnosis of Atypical Smear between Conventional and Liquid Based Papanicolaou Smear in Suburban Area of Thailand
Authors: Phaliwong Paweena , Pariyawateekul Piyawan , Khuakoonratt Nathaya , Sirichai Worrawan , Bhamarapravatana Kornkarn , Suwannarurk Komsun
Published: August 2019

Objectives: To evaluate the prevalence of silent high grade cervical intraepithelial neoplasia diagnose in atypical squamous cells of undetermined significance (ASC-US) in cytology result between conventional (CPP) and liquid-based cervical cytology (LBP) methods to suggest the proper management for Thai women.Methods: This retrospective study was conducted at Bhumibol Adulyadej Hospital, Bangkok, Thailand between January 2011 and December 2016. Medical records of 28,564 patients who attended for cervical cancer screening were reviewed. Prevalence of silent high grade cervical intraepithelial neoplasia (CIN) in atypical squamous cells of undetermined significance (ASC-US) cytology result was determinedResults: During the study period, 28,564 cases were enrolled. There were 22,552 and 6,012 of CPP and LBP cases, respectively. A total of 644 cases of ASC-US cytology were enrolled. In women with ASC-US in cytology, the mean age was younger than women with negative screening cytology group and approximately 70% were in pre-menopausal status. Prevalence of high grade cervical intraepithelial neoplasia in ASC-US cytology from CPP and LBP were 9.5 and 11.9%, respectively. Ten percent (23/248) of atypical glandular cytology pattern was cancer. One-quarter of them was endometrial cancer.Conclusion: Silent high grade cervical intraepithelial neoplasia in ASC-US cytology and the rate of cancer in atypical glandular cytology pattern were high. We recommended colposcopy for women who had the cervical cytological report as atypical squamous and glandular cytology pattern.
Clinico-pathological Characteristics and Survival Analysis of 300 Thyroid Cancer Cases in One Referral Hospital in Kelantan, Malaysia: A 10-year study
Authors: Hayati Othman Nor , Nadiah Abd Ghani Nurul , Zaini Mohd Nor
Published: August 2019

Introduction: Thyroid cancer is ranked fourth in a state of Kelantan, while ranked much lower in other states in Malaysia. We determined the clinicopathological characteristics and the survival analysis of each thyroid cancer type seen in Hospital Universiti Sains Malaysia (HUSM), a referral hospital in the East Coast region of West Malaysia. Methods: Registry of patients diagnosed with thyroid cancer from years 2006 to 2015 was obtained from the medical record office of HUSM. Close scrutiny of the registry was carried out manually to ensure no duplicate entry. The data obtained were age, gender, histological diagnoses and dates of clinical follow-ups. The data were analyzed using IBM SPSS statistics version 24 for Windows. Survival analyses were carried out using Kaplan Meier approach. Results: A total of 300 patients with thyroid cancer were recorded in this 10 year period. The average rise of cancer per year was 27.2%. The most common tumor type was papillary; 230(76.7%) followed by 58(19.3%) follicular, 10(3.3%) anaplastic and 2(0.7%) medullary carcinomas. Female to male ratio was 4.1:1 (p=000). All anaplastic carcinoma cases were women. The age ranged from 11 years to 86 years with the mean age for women at 49.78 years (SD15.17) and for men at 53.27 years (SD14.45). The peak age for papillary carcinoma was in the 5th decade. The 5-year survival of papillary was 94%, follicular 88% and anaplastic 30% and the two medullary carcinoma cases are still alive after 5 years. In general, women had higher survival than men for papillary and follicular carcinoma. Those below 40 years old had the better prognosis compared to older patients.Conclusion: The frequency of thyroid cancer in Kelantan is increasing over the years. The peak age of the patients is older than those thyroid cancers associated with radiation exposure. The 5-year survival for all cancers is comparable with other countries.
Epithelial Borderline Ovarian Tumor: Clinicopathological Features, Outcome and Prognostic Factors
Authors: Temtanakitpaisan Amornrat , Kleebkaow Pilaiwan , Aue-aungkul Apiwat
Published: August 2019

Objective: To evaluate clinic-pathological characteristics, treatment outcomes, factors affecting survival in patients with borderline ovarian tumors (BOTs).Methods and Objective: Medical records of patients with BOTs who had been treated at Srinagarind Hospital from 2001 to 2016 were reviewed. Abstracted data included baseline characteristics, clinic-pathologic features, disease-free survival (DFS), and overall survival (OS). Results: Fifty-two patients with BOTs were included in the study.The mean age+ SD was 41.15+ 15.34 years. Most patients were premenopausal and the most common presenting symptom was adnexal mass. Most patients were in the early stage (90.4%). Thirty-two patients underwent radical surgery (61.5%). Twenty-one patients (40.3%) underwent lymphadenectomy. An appendectomy was performed in 19 (36.5 %) cases. The median follow-up period was 67.5 months (range, 7 to 180 months). The 5-year and 10-year overall survival rates for all stages were 90% and 85%, respectively. The 5-year and 10-year disease-free survival rates for all stages was 87% and 87%, respectively. Seven (13.5 %) patients had the recurrence. Absent residual disease (HR = 0.33; 95 %CI 0.11 – 0.96) and receiving postoperative adjuvant chemotherapy (HR = 0.22; 95 %CI 0.08 – 0.65) were associated factors for DFS. Conclusion: The majority of patients with BOTs presented at the young age and early stage. Residual lesion and adjuvant chemotherapy are significant factors predicting DFS.
Descriptive Epidemiology of Malignant primary osteosarcoma in Tunisia 1980-2016
Authors: Ksontini Feryel Letaief , Guermazi Fatma , Khadija Meddeb , Amina Mokrani , Yosra Yahiaoui , Azza Gabsi , Henda Rais , Nesrine Chraiet , Mouna Ayadi , Amel Mezlini
Published: August 2019

Background: Osteosarcoma is a rare malignant tumor of the mesenchymal tissue that accounts for 5% of all malignant tumors in children and teenager. The purpose of our study was to describe the epidemiological and evolutionary characteristics of osteosarcoma in Tunisia.Methods: It's a retrospective study performed in the Oncology Department of Salah Azaiez Institute from January 1980 to December 2016. We analyzed records of 200 cases of patients with primary high-grade osteosarcoma.Results: The mean incidence was 6 cases per year. The mean age at the time of diagnosis was 19 years with a slight male predominance (55%). The distribution had a single peak during adolescence and a plateau during adulthood. The average consultation period was 3.4 months. The most common reasons for consultation were the pain (82%), followed by swelling (74%), trauma (10%), fracture (6.5%), and functional impairment (5.5%). Mean tumor size was 11 cm. Preferred site was long bones in young patients and flat bones in elderly ones. Common osteosarcoma was the most frequent (85%). Overall survival and progression-free survival at 5 years were respectively 78% and 90.5%.Conclusion: In summary, this study is a large national population-based incidence report of osteosarcoma in Tunisia.
High Dropout & Early Deaths on Chemotherapy in Real World Sounds Alarm Bells: Audit from Department of Medical Oncology of a Tertiary Care Cancer Centre in South India
Authors: Smita Kayal , Biswajit Dubashi , Sunu L. Cyriac
Published: August 2019

Background: Comprehensive data on early outcome of cancer management including treatment drop out, mortality, follow-up and survival, for all registered cases is scarce.Methods: From a prospectively maintained record system in the department of Medical Oncology, an audit was done for all patients registered in the calendar year 2015 for diagnosis, treatment course, follow-up and vital status. We follow a system of outpatient clinic booked appointment and for patients who default, serial phone calls are made to counsel about compliance and give a next review date.Results: Of total 1173 cases registered, 73.5% had solid (n = 863), and 25.5% had hematological malignancies (n = 300). Median age was 48 (1 month – 85 years); 11% pediatric, 72% adults and 17% were elderly. Male to female ratio was 0.74:1. Five most common cancers were breast (27.7%), lymphoma (11.6%) acute leukemia (9.4%), esophago-gastric (9.2%), followed by ovarian and lung carcinoma, 7% each. Almost a quarter (28%) were lost to follow up (LTFU) on different treatment phases and another one third (33%) had died during the study period. Almost half of all deaths were for patients on chemotherapy with either curative or palliative intent. Significantly higher rate of LTFU was noted for patients’ age > 18 years, with solid malignancies and with longer distance (>100 kilometres) from hospital.Conclusion: Periodic audit is essential for effective functioning of any cancer treatment program. High rates of treatment defaults and early deaths on chemotherapy demands strengthening of counselling and supportive care services to improve overall outcomes.
Molecular Monitoring of Chronic Myeloid Leukemia in Chronic Phase (CML-CP)
Authors: Payandeh Mehrdad , Aeinfar Mehrnoush , Yari Saba , Yari Khirollah , Sadeghi Masoud
Published: August 2019

Objective: Quantification of the BCR-ABL transcript is recommended to follow-up CML patients that treated by Imatinib mesylate (IM) as a tyrosine kinase inhibitor. BCR-ABL transcripts have been recognized as a molecular marker for response to therapy in CML patients (pts). Monitoring of this marker to be more effective for identifying optimal responses and can help to inform the decision to switch to alternative therapies. Quantitative reverse transcriptase PCR (Q-PCR) of BCR-ABL1 RNA is a critical laboratory technique for accurate and sensitive monitoring of the efficiency of tyrosine kinase inhibitor therapy. The aim of our study was to analyze the molecular response (MR) in Kurdish CML patients who are treated with Imatinib.Materials and Methods: We studied 60 blood samples from CML patients in chronic phase (CP), 36 females and 24 males, under IM treatment and monitored by Q-PCR on 12 months. The median duration of CML was 5 years (range: 1-15). The median duration of IM treatment was 4 years (range: 1-10). Results: 40% (24 pts), 28.33% (17 pts) and 15% (9 pts) and respectively had reached early molecular response (EMR) at 1.0-2.0 log, major molecular response (MMR) at 3.0 log and deep molecular response (DMR) at 4.0-5.0 log and also undetectable BCR‑ABL1 levels (CMR) were achieved in 16.67% (10 pts) at 12 months.Conclusion: We highlighted the possibility to use of Q-PCR as a warning at diagnosis, and may use to identify patients who could benefit from a more scrupulous follow-up.
The Effect of Curcumin in Combination Chemotherapy with 5-FU on non-Malignant Fibroblast Cells
Authors: Sarkhosh Hassan , Ahmadi Zohre , Akbarzadeh Khiyavi Azim
Published: August 2019

Background: Curcumin has long been known to possess therapeutic properties and recent research have shown that it can inhibit malignant cell proliferation in vivo and in vitro. However, studies on combination therapy with curcumin and chemotherapeutic drugs are so limited. Methods: With this regard, we studied the effect of curcumin on the toxicity of 5-Flouracil(5-FU) in the treatment of normal fibroblasts in vitro using L929 (nonmalignant fibroblast cell) cell line. Curcumin in the doses of 5 and 15 μM was used. First control groups treated to curcumin, alone while second control groups received the chemotherapeutic drug, separately. Experimental groups received curcumin in combination with 5-Flouracil. Cell viability was measured after 24, 48, and 72h through MTT method. Statistical differences were analyzed by ANOVA test.Results: At all studied times in combination cases (curcumin+5-FU) with increasing concentration of curcumin, toxicity was decreased. Indeed, curcumin in combination with 5-Fu in low concentration inhibited the effect of 5-FU (p<0.05).Conclusion: It can be concluded that curcumin in combination therapy with 5-FU may induce lower toxicity in normal cells and reduce possible side effects.
Knowledge and Health Beliefs of Nursing Students Toward Human Papilloma Virus and Vaccine Use
Authors: Kamberi Fatjona , Muhaj Eva
Published: August 2019

Objective: Human Papilloma Virus (HPV) infection is the most common sexually transmitted among young people of both sexes. It is also the main cause of cervical cancer. This study aimed at assessing students’ knowledge and health beliefs about HPV infection and the use of the vaccine.Methods: The sample of the cross-sectional study was 120 randomly selected nursing students from the Faculty of Public Health, University of Vlore “Ismail Qemali” Albania. Anonymous, self-administered questionnaire based on the literature and Health Belief Model, was used for data collection in May 2017. The questionnaire included assessment questions for students’ knowledge and health beliefs about HPV and vaccine use. Also, questions about socio-demographic characteristics were included. Data analysis included the calculation of averages, frequencies, and confidence intervals. P values ≤0.05 were accepted as statistically significant.Result: Mean age 20.3±2.2 years, 92.44 % of students were female. 65.83% of students know that HPV is a sexually transmitted infection and a vaccine is available to prevent it. Ambiguities and uncertainties exist in regard to screening with Pap test after vaccination. Perceived benefits are high for 50.83% of students. Perceived severity appeared low as only 25% of students agree that they may be affected by HPV. Statistical association, p =0.0347 was found between perceived risk and the year of study. The parents’ role in vaccination against HPV have a strong statistical association, p=0.0058 with the year of study as only 8.33 % of students in the third year agree with the fact that that parents do not allow them to be vaccinated against HPV. Conclusion: The study noted the student’s ambiguity and misconceptions about HPV infection. Low severity and lack of knowledge about the vaccine emphasizes that identifying their current level of knowledge and the main source of information are essential to provide comprehensive and appropriate health education.
Adult-type Granulosa Cell Ovarian Tumor: Clinicopathological Features, Outcomes, and Prognostic Factors
Authors: Temtanakitpaisan Amornrat , Kleebkaow Pilaiwan , Aue-aungkul Apiwat
Published: August 2019

Objective: To evaluate the clinicopathological features, outcomes and prognostic factors affecting the disease-free interval in women with adult-type granulosa cell tumor.Methods: A retrospective descriptive study of patients with adult-type granulosa cell tumors of the ovary (AGCTs) during January 2001 to October 2016 were recruited. The data record of all patients was analyzed to determine clinic-pathological features, treatment, survival, and prognostic factors.Results: Eighteen women with adult-type granulosa cell tumors (AGCTs) were diagnosed. The mean age+ SD was 48.72+ 5.95 years. The adnexal mass was the most common presenting symptoms (83.3%) and most were diagnosed in FIGO stage I (83.3%). The majority of patients (55.6 %) were treated with complete staging surgery. Additionally, 22.2% were given postoperative chemotherapy. Endometrial cancer was detected in only one case. The mean follow-up period+ SD was 43.11+ 26.02 months. No recurrence of disease was observed in all patients. The estimated 5-year disease-free survival (DFS) was 95% regardless of the stage of the disease. The stage disease slightly influenced disease-free survival. However, no statistical difference between stages (p=0.52). No prognostic factors associated with DFS significantly.Conclusion: The majority of the patients with adult-type granulosa cell tumors of the ovary (AGCTs) presented in the early stage of disease and have an excellent survival rate. Tumor removal procedure with or without complete staging surgery seemed to be the appropriate treatment for granulosa cell tumors. No prognostic factors affecting on disease-free survival rate was found.
Pattern of Health-Related Quality of Life and its Association among Patients with Colorectal Cancer
Authors: Magaji Bello Arkilla , Moy Foong Ming , Law Chee Wei , Sii Hoe Leong , Roslani April Camilla
Published: August 2019

Aim: Research on patient-reported outcomes in colorectal cancer are scarce in Malaysia. We aimed to determine pattern of health-related quality of life and its associations among patients with colorectal cancer.Methods: A cross-sectional study of 324 patients. Data were drawn from patient’s records and interviews. Research tools included the locally validated European Organization for Research and Treatment of Cancer (EORTC) core QLQ-C30 and colorectal-cancer specific QLQ-CR29 questionnaires.Results: The mean (±standard deviation) age of patients was 62.5 (±13.6) years. Majority of them were Chinese (62.3%) followed by Malays (19.8%), Indians (14.8%) and others (3.1%). Colon cancer was 7-fold more common than rectal cancer (87% vs 13%). Majority of them were presented at Stage II (29.6%) and III (28.1) of TNM Staging. The mean (±SD) score for global health status/quality of life (GHS/QOL) was 73.13 (±14.19). Good overall functionality (mean scores ≥80) was observed for physical, emotional, role, cognitive and social/family for QLQ-C30; body image, anxiety and weight for QLQ-CR29. The mean score for sexual functioning in men (32.95±28.81) and women (17.56±25.60) were low. Commonest symptoms were fatigue (22.29±17.40), urinary frequency (21.96 ± 24.22) and insomnia (18.42 ± 23.32). Those with lower GHS/QOL had stoma (p=0.044) and were of Chinese ethnicity (p<0.001). On multivariate analysis, ethnicity was the only independent predictor of GHS/QOL (95% confidence interval, 2.589 to 6.139, p<0.001). Conclusion: Our results suggest that there is decrease in sexual functioning despite good overall GHS/QOL among our colorectal cancer survivors. Fatigue, sleep loss and urinary frequency were the common symptoms after cancer treatment. Chinese patients had the poorest quality of life.
Gestational Trophoblastic Neoplasia: A Tunisian Multicenter Study
Authors: Rachdi Haifa , Mokrani Amina , Batti Rim , Raies Henda , Touhami Omar , Ayadi Mouna , Meddeb Khadija , Letaief Feryel , Yahiaoui Yosra , Chraiet Nesrine , Mezlini Amel
Published: August 2019

Gestational trophoblastic disease (GTD) develops from abnormal cellular proliferation of trophoblasts following fertilization. It includes benign trophoblastic disease (hydatidiform moles (HM) and the malignant trophoblastic diseases or gestational trophoblastic neoplasia (GTN). The frequency of the GTD in Tunisia is one per 918 deliveries. The aim of this study is to analyze the clinical characteristics, treatment and outcomes of GTD at Salah Azaiez Institute (ISA). Medical records of women diagnosed with GTD at ISA from January 1, 1981 to December 31, 2012 were retrospectively reviewed. FIGO (International Federation of Gynecology and Obstetrics) score was determined retrospectively for patients treated before 2002 One hundred and nine patients with GTN were included. Patients presented with metastases at 43% of cases. The most common metastatic sites was lung (30%) and vagina (13%). 56 (51%) patients had low-risk and 21 (19%) cases had high-risk, the FIGO score was not assessed in 32 cases. After a median follow-up of 46 months, 21 patients were lost to follow-up, 12 patients died, 19 progressed and 8 relapsed. At 10 years, the OS rate was 85% and the PFS rate 79%. OS was significantly influenced by the presence of metastases at presentation (M0 100 % vs. Metastatic 62 %; p < 0.0001), FIGO stage (I-II 100% VS 61% and 65% for stage III and IV; p < 0.001), FIGO score (low-risk 99 % vs. high-risk 78 %; p < 0.001). GTN is a significant source of maternal morbidity with increased risk of mortality from complications if not detected early and treated promptly.
Factors Associated with Mortality in Patients with Gastric Cancer at a Reference Hospital
Authors: Arruda Aragão Francisca Bruna , Bastos dos Santos Gerusinete Rodrigues , Da Silva Brasil Gabrielle Vieira , Carvalho Campelo Bruno , Coelho Galvão Ana Patrícia Fonseca , Dos Santos Pereira Joelmara Furtados , Vasques Rodrigo Rodrigues , De Figueiredo Fábio Vidal , Dos Santos de Oliveira Ana Mônica Abreu , Diniz Pinho Jaqueline , Lopes da Silva Rodrigo
Published: August 2019

Background: Gastric cancer (GC) is the second cause of death by tumor in the world. In Brazil, the survival rate of patients with GC is only five years, due to the low rates of early diagnosis, with about 10 to 15% of the cases. Thus, this study aims to evaluate the factors associated with mortality in CG patients treated at a reference hospital. Method: The study was carried out based on the survey of 96 medical records of patients diagnosed with GC, whose analyzed data were: sex, age, educational level, occupation (socioeconomic level), and risk factors, such as smoking, alcohol consumption, family history of cancer, staging and type of treatment adopted, among other variables. Statistical analysis was performed using the Statistical Package for the Social Sciences (SPSS-PC) and Kaplan-Meier for survival analysis. Absolute and relative frequencies were calculated for all variables. Results: The sample consisted mainly of male patients with stable union, brown-colored, who lived in the metropolitan region and presented low schooling. In addition, risk factors such as smoking and alcoholism presented a high prevalence in the sample. Regarding mortality, factors such as arterial hypertension (p = 0.1581), diabetes (p = 0.3212), and alcohol consumption (p = 0.6704) were not associated with increased mortality in this study.Conclusion: The clinical and epidemiological profile of patients with GC presented a low degree of tumor differentiation, with predominance of the mixed or unclassifiable subtype. In addition, the majority of the sample was composed of patients living in the metropolitan region and the main form of treatment adopted was surgical intervention in combination with chemotherapy.
Biochemical Characterization of Multiple Myeloma Patients across ISS Stages – A Data Base Workup from a Tertiary Care Hospital in India
Authors: Mohammed Noorjahan , Sai Baba KSS , B Yadagiri , Gundeti Sadasivudu , Raju Sree Bhushan
Published: August 2019

Background: Multiple myeloma (MM) is slowly becoming a huge medical burden, challenging the health-care systems of Asian countries. Because of the unavailability of widespread access to various modalities of investigations, and paucity of well compiled data on common presenting features and various laboratory parameters in various stages of MM in India, the diagnosis is usually delayed till complications begin to occur. This study is an attempt to fill this gap and to establish database for future reference. Methods: The study was conducted in a tertiary health care centre over a span of 3 years and 94 patients diagnosed as MM with complete workup including beta2 microglobulin (β2M), bone marrow plasma cell percentage, serum protein electrophoresis, serum and urine Immunofixation and serum Free Light Chains (FLC) were included. The various laboratory parameters were statistically analyzed across ISS stages I, II and III. Results: We found a male to female ratio of 1.47:1. The mean age of patients was 55.5±11.78 yrs. Backache was the most frequent presentation (30%) of the patients followed by generalized weakness (22%). The percentage of plasma cells, hemoglobin, urea, creatinine, uric acid, calcium and β2M showed significant difference across the stages. 38.3% of the patients were in stage III, 29.8% in stage II and 31.9% in stage I. IgGκ type constituted 70%, other fraction being IgGλ (10%), IgMκ (10%), IgAκ (5%) and IgAλ (5%). M band was not seen in 11% of patients.Conclusion(s): The presentation of MM is nonspecific and patient can come with varied presentations at onset. We have biochemically characterized the three stages of MM and this will form a basis for further larger studies on these lines and to develop stage-based algorithms for early and better diagnosis and prognosis of MM.
Clinicopathological Profile of Cervical Carcinoma: An Experience of Tertiary Care Cancer Centre
Authors: Rana Manjit Kaur , Singh Karuna , Mahajan M K , Singh Rana Amrit Pal
Published: August 2019

Context: Cervical cancer is a malignant neoplasm arising mainly in the transformation zone of the cervix. Cervical cancer is the second most common cancer among women worldwide after breast cancer. Squamous cell carcinoma and adenocarcinoma constitute the greatest burden, globally as well as in India.Aims: The current study was aimed to assess the histopathological profile and its correlation with clinical findings.Settings and Design: It was a retrospective analysis of the patients of cervical carcinoma. Methods and Materials: The retrospective analysis of histopathological patterns of carcinoma cervix was done. A total of 120 cervical biopsies were received, amongst which 5 biopsies were chronic cervicitis, 9 were cervical intraepithelial neoplasia (CIN) and 106 cases were of carcinoma. Further histologic subtyping of cervical carcinoma was done and was correlated with clinical presentations and stage. The collected data were analysed. Statistical analysis used: Analysis of data was done for simple means and percentages.Results: The most common age group in carcinoma cervix was fifth and sixth decade with history of bleeding per vagina being the most common clinical presentation. Squamous cell carcinoma (SCC) was the most common variant, ≥Stage III case constituted in majority and also showed poor prognosis.Conclusion: A majority of Indian women presented at later stages of cervical cancer, hence demanding the need of dedicated screening programes. Many variants present with different clinical findings especially as deep infiltrative growth patterns, hence histologic types should be kept in mind clinically while dealing with unfamiliar clinical presentations. In our experience most of the women presented in later stages and patients with ≥ stage III showed poor prognosis.
Quality of Life among Caregivers of Lower-Income Cancer Patients: A Single-Institutional Experience in India and Comprehensive Literature Review
Authors: Vashistha Vishal , Poulose Rosemary , Choudhari Chandrashekhar , Kaur Sukhdeep , Mohan Anant
Published: August 2019

Objectives: Quality of life (QOL) among caregivers of cancer patients is often diminished. For lower-income caregivers, the deterioration in QOL may be of greater impact. We aimed to evaluate QOL among lower-income cancer caregivers in Delhi, India and to comprehensively review similar investigations conducted internationally.Methods: A Hindi-version of the Caregiver Quality of Life Cancer (CQOLC) index was administered to 89 caregivers of lung cancer patients. Bivariate analyses were employed to evaluate associations between baseline demographics and CQOLC index scores. A systematic review of PubMed, EMBASE, and PsychInfo was undertaken.Results: Reduced QOL was observed for caregivers residing in homes earning less than our center’s median annual income per capita (p < 0.01) and for caregivers providing aid for 4 months or longer (p < 0.01). The burden of caregiving contributed most to summative index scores (p < 0.01). Eleven studies were selected by systematic review. Lower-income caregivers in Asia and the Middle East experience reduced QOL and increased burden. Available evidence does not suggest that lower-income caregivers in Europe and North America share worse QOL.Conclusion: Lower-income caregivers suffer loss in QOL, particularly in the developing world. Resourceful interventions are warranted to mitigate burden for this underappreciated population.
Psychological Impact of various Therapeutic Modalities in Childhood Malignancy
Authors: Eldin Ibtessam Saad , Shahin Ola O , Makar Wael S , Eldin Sara H Shams
Published: August 2019

Background: The purpose of the study is to evaluate and compare the psychological impact of various therapeutic modalities in pediatric cancer by comparing them to healthy children across age groups.Methods: The semi-structured and the Mini International Neuropsychiatric interview (M.I.N.I Kids Test) were administered to 80 children including 40 cancer patients and 40 healthy children. Results: CNS tumors were the most commontumor 47.5% followed by heamatological malignancies 35% and Non CNS solid tumors 17.5%. About two thirds of the sample reported social problems followed by school problems in 57.5% of cases. By analyzing the mood changes, there was significant depression, anxiety disorders, panic attacks and separation anxiety between the patients and the control (p= <0.001). The patients had also significant lack of attentionand stubbornness (p=<0.001). These problems did not show any difference between sex except for depression and social worries which were more in girls. These symptoms did not show any difference as regard receiving or not chemotherapy, radiotherapy or combination. Conclusion: The psychological problems were more evident in cancer patients compared to healthy children and was higher than developing countries. The present study highlighted the need of a health care team and integration of a comprehensive psychological support in the treatment plan in Egypt. This will improvequality of life and reduce the burden of treatment.
Clinical Prognostic Factors and Treatment Outcomes for the Survival of Patients with Cholangiocarcinoma in the Eastern Region of Thailand
Authors: Chanchai Charonpongsuntorn , Piyasatit Piyanuch , Muntham Dittapol , Chommaitree Piyanant , Muangnoi Panunat
Published: August 2019

Background: Cholangiocarcinoma (CCA) is an uncommon primary liver cancer worldwide but it commonly in Asia including Thailand. Although increasing incidence but the prognosis is poor and lethal cancer. Prognostic factors for CCA that affect survival outcomes are various due to a vary presentation and different diagnostic and therapeutic modalities. To date, satisfactory prognostic factors have not been understood. Objective: This study evaluated clinical prognostic factors and treatment that affect survival outcomes in patients with CCA.Methods: The CCA patients were identified from the database between January 2012 and December 2016. A retrospective review of 82 medical records was performed. Median follow time was more than 12 months. Survival outcome was estimated using Kaplan-Meier analysis. Demographic, clinical presentation, Laboratory, histopathological data and treatment modalities that affect survival were evaluated for prognostic factors relating to mortality by using univariate and multivariable statistical analysis.Result: 82 patients were identified. Median overall survival was 11.1 months. An unresectable or metastatic CCA patient was 74.4% (61/82). Cox-regression univariate reports Higher Alkaline phosphatase level, Prolong Prothrombin time, Higher WBC count, Higher CA 19-9 level, Unresectable, Metastasis were identified as important clinical predictors of patient mortality. Treatment modalities factors that significantly affect survival outcome were Bile duct drainage, surgery, and palliative chemotherapy. A Poor prognostic outcome of survival depends on staging by resectability and metastasis (P < 0.01). Conclusion: In this study identified that potential of surgery as the mainstay of treatment provided the best survival prognosis of patients with CCA. Treatment involving both bile duct drainage and chemotherapy also prolong CCA patient survival. Poor clinical prognostic factors which shorten survival are prolonging PT, higher WBC, ALP, and CA19-9.
Metaplastic Carcinoma with Foci of Chondrosarcoma in Breast: A Rare Case
Authors: Vias Poorva , Pandey Awadhesh Kumar , Dimri Kislay , Bhagat Ranjeev
Published: August 2019

Metaplastic carcinoma of breast is a rare form of tumour in which there is a mixture of malignant mesenchymal and epithelial elements. In these tumours cancerous cells of epithelial origin are found in combination with non-specific malignant spindle cells of mesenchymal origin. It is an aggressive form of cancer and usually appears in late stages.
Leukemia Epidemiology in Karbala province of Iraq
Authors: Mjali Ahmed , Hasan Jaleel Al-Shammari Haider , Tawfeeq Abbas Nareen , Deheyaa Azeez Zahraa , Khudhair Abbas Saja
Published: August 2019

Objective: Investigate epidemiology of leukemia in Karbala province of Iraq, compare and identify possible changes with other populations. Methods: This was retrospective descriptive study for more than 400 leukemia patients in Karbala province from November 2011 to May 2018 with evaluation of age, gender distribution, types distribution and frequency distribution types of leukemia according to age and gender.Result: About 402 patients with leukemia were retrospectively enrolled in this study at median age of 30 years. Males accounted for a higher proportion of leukemia patients, 58.2 % compared to 41.8% females, with a male to female ratio of nearly 1.4:1. Acute lymphoblastic leukemia (ALL) was the most prevalent in the study group, contributing 41% (median age 10 years), followed by chronic myeloid leukemia (CML) 24.1% (median age 42 years), acute myeloid leukemia (AML) 19.2% (median age 36 years) and chronic lymphocytic leukemia(CLL) of less frequent type which contributed only 15.7% (median age 60 years). Conclusion: This is the first statistical study of leukemia in Karbala. It can be used as basic information to investigate epidemiological characteristics, to evaluate progress in recent years and to develop future leukemia strategies. More statistical leukemia analyses in Iraq are needed.
Lingual Osseous Choristoma: A Case Report and Review of the Literature
Authors: Saraydaroglu Ozlem , Narter Selin , Ozsen Mine
Published: August 2019

Introductıon: Osseous choristoma is a benign lesion that is characterized by proliferation of mature osseous tissue in an abnormal anatomical location. The lesion, which was first described by Monserrat in 1913 as “lingual osteoma” has been called “osseous choristoma” since 1971. Here, we present a rare case of osseous choristoma located on the tongue and a review of the literature.Case Report: A 26 year-old male patient was referred to the Department of ENT with the complaint of swelling of the tongue. Physical examination showed a nodular, sessile lesion on the base of the tongue and the lesion was removed. Histopathological examination of the material revealed a well-defined, submucosal lesion consisting of mature bone tissue and was reported as “osseous choristoma”.Conclusıon: Osseous choristoma is a benign lesion that occurs mostly in women in their second or third decades of life, although it can be seen in a wide age range. Osseous choristoma may occur in different locations of the oral cavity and maxillofacial region such as the tongue, buccal mucosa, alveolar mucosa, submandibular region, submental region, masseter muscle and palate. This rare entity should be kept in mind because it may be confused with other benign lesions of the tongue like hemangioma, lymphangioma, hamartoma and malignant tumors.
STUDI LAYANAN INFORMASI BERBASIS STIFIn UNTUK SISWA KELAS IX DI SMP IT ROBBANI BANJARBARU
Authors: Rahmadani Rahmadani , Jarkawi Jarkawi , Handayani Eka Sri
Published: August 2019

The teenage phase is a fairly critical phase so that every teenager needs a suitable environment so that later they are able to achieve achievements in the family, school and community. Based on this, an environment that is designed in the family, school and community is needed so that each individual can develop according to his potential. Although basically schools are not the only institution that forges students but schools have a considerable impact on the formation of an individual. Therefore, researchers are interested in implementing STIFIn-based Information Services with the aim of optimizing the potential of students. The method used in this study is qualitative. The subjects in this study were students of class IX Rabbani Banjarbaru IT Middle School. The sample in this study were 1 teacher, 2 students, and 2 studaents.The implementation stages of STIFIn-based Information Services for grade IX students at Rabbani Banjarbaru IT Middle School start from the process of exploring the needs of students after the explanation service of the results of the STIFIn-Based Personality Test, to adjust the needs of students then the information service content provided is STIFIn-based Learning Information Services.The results showed that not all information content could be understood, because there was the use of foreign languages and scientific terms that were not familiar to students. In addition, the results and explanation of STIFI-based personality tests are not fully recognized by students, this is due to the environmental factors that influence students in carrying out their developmental tasks.
PENGARUH LAYANAN KONSELING INDIVIDUAL DALAM MENINGKATKAN KECERDASAN INTELEKTUAL DAN EMOSIONAL DI SMKN1 BINUANG
Authors: Suciyanti Suciyanti , Yuliansyah Muhammad , Auliah Nurul
Published: August 2019

Binuang Vocational High School 1 often found students lacking in concentration in class when the lesson took place. Based on the identification of the problem, due to lack of understanding of students in dealing with emotional students faced in the implementation of learning. For this reason, it is necessary to conduct research on the effect of personal counseling services in improving intellectual and emotional intelligence. The aim is to find out how much influence personal counseling services have on intellectual intelligence and emotional intelligence. This research was carried out on 11 August to September 2017 with a location in Binuang 1 Vocational High School. The data is collected through interviews with respondents using a questionnaire. The study sample was taken through three stages, the school level was appointed, the class determination (two classes) was appointed, and then continued with a simple random to determine 30 respondents. Data analysis using regression results of the study shows that X against Y1 F count (18,380) is greater than F table α 0,05 df 1/28 (4.20), then Ho is rejected and Ha is accepted. X against (Y2), the calculated F value (22,413) is greater than F table (4.20) so Ho is rejected and Ha is accepted. Personal counseling services affect intellectual intelligence and emotional intelligence. It was concluded that the variable personal counseling service (X) can be used as a recommended variable in estimating the variables Y1 and Y2.
FAKTOR PENGHAMBAT DALAM PELAKSANAAN KONSELING ONLINE BERBASIS TEKS (CHAT)
Authors: Haryadi Rudi , Rahmah Fauziatin Noor , Khatimah Khusnul , Irmahwati Susi
Published: August 2019

In the current era of globalization, all technologies are developing rapidly and sophisticated. This is used by all individuals well in helping their work, as well as the world of Guidance and Counseling is greatly helped by the existence of increasingly sophisticated technology. There is no need to worry about distance constraints, because counselors and counselees can still do counseling through the media called online counseling. One of them is through text (chat), this media is very easy to do counselors and counselees because they only communicate by writing or making text. Media chat also helps counselees who have a shy or awkward attitude when meeting directly with a counselor. They only type in a text form to the counselor about the problem. Similar to general counseling, online counseling through media chat also has obstacles in its implementation. This inhibiting factor can be caused by the counselor and his own counselor. The inhibiting factor of the counselor itself is the lack of special knowledge or abilities that the counselor has in communicating through media chat and the lack of skills in writing texts to avoid misunderstandings with the counselee. Likewise counselees such as lack of understanding in using technology also become one of the inhibiting factors. The reason for this article is to find out more about some of the inhibiting factors in counseling through media chat.
TEKNOLOGI ARTIFICIAL INTELLIGENCE DAN POTENSI PEMANFAATNYA DALAM KONSELING ONLINE DI MASA DEPAN
Authors: Haryadi Rudi , Matarif Jamaluddin , Budiono Kabul
Published: August 2019

Counseling activities that we usually carry out are usually face-to-face processes, as the times develop, counseling activities turn into online counseling where counseling uses technology intermediaries including chat, email, video conferencing, audio, and so on. But in the future with highly developed technology that is rapidly advancing online counseling based on Artificial Intelligence (AI) will be born with a new breakthrough that is more effective and efficient in future online counseling services, for that in this article the author will discuss online counseling, Artificial Intelligence (AI), the potential use of Artificial Intelligence (AI) in online counseling in the future, and differences in artificial intelligence and natural intelligence.
PERANCANGAN SISTEM RESERVASI GEDUNG DAN AULA BERBASIS WEB DI WILAYAH BANJARMASIN
Authors: Setiawan Agus , Muin Agus Alim , Ramadhani Budi
Published: August 2019

Gedung dipilih berdasarkan kapasitas ruang, fasilitas umum, dan fasilitas khusus, lokasi gedung, luasnya halaman dan lain-lain. Banyak orang memilih menggunakan  gedung untuk melaksanakan suatu event karena disesuaikan dengan besar kecilnya suatu event tersebut. Hal yang sering menjadi faktor pertimbangan bagi penyewa dalam memilih gedung yang tepat adalah lokasi gedung, kapasitas ruang, fasilitas yang tersedia (panggung, meja, kursi, toilet, daya listrik dan air pam), halaman parkir yang memadai, kondisi di lingkungan sekitar, dan Manajemen waktu penyewa. Kendalanya terkadang sebelum memilih gedung, penyewa harus ekstra fisik untuk survey ke beberapa tempat atau gedung, karena terkadang tidak ada yang tahu koordinasi waktu penggunaan gedung tersebut antara gedung yang satu dengan gedung lainnya. Dengan adanya sistem ini diharapkan menjadi informatif dan memudahkan bagi penyewa dalam mengakses seluruh informasi mengenai gedung-gedung yang mereka inginkan mulai dari mengelola seluruh informasi yang diperlukan bagi penyewa, mulai dari jarak terdekat, budget, kapasitas, fasilitas penunjang dan waktu kosong yang bisa di booking penyewa Kata Kunci : Gedung, Aula, Penyewa, Kapasitas, Budget, Fasilitas, Booking, Sistem
IMPLEMENTASI APLIKASI MENU PADA RESTORAN JAPANESE FOOD KENZO BENTO BANJARMASIN
Authors: Amin Muhammad
Published: August 2019

Sebagai salah satu restoran baru berkonsep Japanese food khususnya menu bento dan mie ramen, restoran kenzo bento banjarmasin sudah menggunakan sistem komputerisasi, tetapi hanya sebatas  di bagian pembayaran saja. Untuk membatu pelayanan agar lebih cepat dan bisa langsung terhubung dengan koki didapur maka kami merancang suatu sistem aplikasi menu restoran untuk rumah makan/ restoran kenzo bento Banjarmasin Menggunakan Bahasa pemrograman PHP dan database MySQL. Kendala yang sering dihadapi oleh sebuah restoran yang masih menggunakan pelayanan dan sistem manual yaitu pekerjaan lebih lama dan tidak efisien. misalnya saja saja pemesanan menu ke koki didapur. Dengan adanya aplikasi ini maka pemesanan menu kekoki bisa lebih cepat.  Kata Kunci : Menu ,MySQL , PHP, Restoran
RANCANG BANGUN SISTEM INFORMASI JASA PEMBUATAN PAKAIAN DENGAN ALGORITMA PEMPROGRAMAN TERSTRUKTUR
Authors: Maulani Jauhari , Amin Muhammad
Published: August 2019

Pembuatan pakaian diperuntukan untuk dipakai kegiatan sehari -hari, untuk acara atau untuk pakaian seragam baik perkantortan atau komunitas. Pada setiap harinya para pelanggan datang untuk membuat pakaian pada butik jasa pembuatan pakaian husnah busana. Para pelanggan di data dengan cara dicatat data diri dan data ukuran pada pembukuan secara tulis tangan, buku catatan makin menebal dan makin bertumpuk banyak data dari para pelanggan yang telah dicatat. Pada pelanggan yang sudah pernah di data namun pada sewaktu waktu pelanggan kembali membuat pakaian, pencarian data sulit dilakukan dengan pencarian di catatan pembukuan, membuka lembar - lembar kertas data pelanggan yang sudah ada. perlunya sistem yang terkomputerisasi untuk mempermudah pelayanan pendataan pelanggan dan proses transaksi pelayanan jasa pembuatan pakaian pada butik husnah busana. aplikasi sistem informasi jasa pembuatan pakaian yang akan dirancang dan dibangun dengan menerapkan algoritma pemprograman terstruktur agar lebih mudah dalam pembuatannya dengan struktur logika yang benar dan mudah dipahami serta menyederhanakan kerumitan program. Rancang bangun sistem informasi yang di telah dibuat dapat membuat pendataan dan transaksi lebih cepat serta efektif dan efisien.Kata Kunci: Sistem Informasi, Algoritma, Pemprograman Terstruktur.
ANALISIS PENGENDALIAN PENGEMBANGAN SARANA PRASARANA BERBASIS ANDROID DI PROVINSI KALIMANTAN SELATAN
Authors: Syafarina Gita Ayu
Published: August 2019

Perkembangan teknologi informasi yang begitu pesat membawa pengaruh yang signifikan dalam pola kerja yang efektif dan efisien. Dengan memperhitungkan proses-proses apa saja yang ada didalam system dan mengindentifikasikan ulang serta menyajikan database tentang struktur ruang kedalam peta dan informasi. Oleh sebab itu semua data baik spasial (peta-peta) maupun atribut mestilah dibuat dalam bentuk format digital yang tersusun dalam satu basisdata. Dengan begitu Pengendalian Pengembangan Sarana Prasarana Berbasis Android sepantasnyalah diterapkan dalam mendukung aktivitas perencanaan, pemanfaatan serta pengendalian pengembangan sarana prasarana. Kata Kunci : Teknologi Informasi, Database, Digital, Berbasis Android