bluuebunny/crossref_metadata_2025 huggingface dataset:
A bibliometric analysis of the glymphatic system in cognition from 2009 to 2023
Authors: Ying Xiaoqi , Xu Jingyang , Yu Qintao , Wang Xinru , Lan Songsen , Hu Liwan , Zhang Ying , Han Dexiong
Published: March 2024

Background: Since the discovery of the glymphatic system in mice with clearance functions distributed throughout the brain, more and more scholars have begun to study the glymphatic system. However, there are a limited number of correlations between glymphatic system and cognition. Therefore, this study aimed to evaluate the research trends, hotspots, and frontiers of glymphatic system in cognition using bibliometric analysis.
Methods: Publications from the Web of Science Core Collection (WoSCC) database spanning 15 years from 1 January 2009 to 31 December 2023 were screened. All eligible publication were included based on our comprehensive search strategy. The analysis of annual publications, countries/regions, institutions, journals, authors, co-cited journals, co-cited authors, and keywords was conducted using CiteSpace and VOSviewer, and the hotspots and major ﬁndings of the glymphatic system in cognition were summarised. In addition, ArcGIS software was used to geovisualize the count of publications.
Results: A total of 625 publications were included in this study. Overall, the number of publications has been increasing steadily per year. These publications were published in 59 countries/regions and 149 institutions. Of these, American institutions had the highest number of publications, and their international inﬂuence also ranked first. The journal “Neurology” published the most publications and was considered the most co-cited journal. Wardlaw, Joanna M was the author of the most published articles and the most cited authors. The article entitled “The glymphatic pathway in neurological disorders” published in Lancet neurology had the most citations. The keywords with the highest number of occurrences were “Alzheimer disease” and “small vessel disease”, which were regarded as research hotspots. Three main clusters were shown in the keywords clustering network. Alzheimer's disease and perivascular spaces had been a hot topic for a long time and from 2017 research on GS increased. Among 19 emergent terms, “Virchow robin spaces”, “vascular dementia”, and “autosomal dominant arteriopathy” were the ﬁrst, and “white matter lesions” were the strongest.
Conclusion: Previous research has focused mainly on perivascular spaces, however, with the concept of the glymphatic system was introduced, the correlation of the glymphatic system in cognition have gradually increased. Currently, limited studies have been conducted on the glymphatic system in cognition , and we hope that this study will provide the recommendation for the future research.
Underlying Dynamics of PM2.5 Concentrations in China: Evidence Based on ARDL Approach
Authors: Akça Emrah Eray , Tosun Tayfun Tuncay
Published: March 2024

This study investigates the underlying dynamics of air pollution utilizing time series data from China over the period 2000–2020. In the empirical setting, air pollution is represented by particulate matter 2.5 (PM2.5) concentrations known as the most detrimental ambient pollutant. The empirical model of the study includes several socioeconomic potential determinants of PM2.5 concentrations. The main motivation behind the study is the downward tendency of PM2.5 concentrations in China as of the second decade of the 2000s. At this point, although it is commonly accepted that the Air Pollution Prevention and Control Action Plan implemented by the Chinese State Council has been effective, the underlying specific dynamics of reducing PM2.5 concentrations are not clear. From this motivation, the study unveiled the driving forces of PM2.5 concentrations in the framework of the autoregressive distributed lag model approach. Empirical results put forward the positive impact of economic growth, industrialization, and foreign direct investment inflows on PM2.5 concentrations, while medium- and high-tech exports, and coal rents are found negatively associated with them. In this respect, overall results particularly emphasize the lowering effect of an increase in medium- and high-tech product exports on the PM2.5 concentrations. In this context, to improve the air quality further, the study suggests that China should transform its industrialization structure toward specialization in medium- and high-tech products, and promote foreign direct investment inflows specialized in these types of products. The study provides additional policy recommendations for Chinese policymakers.
Assessing the Impacts of Future Climate Extremes on Boro Rice Cultivation in the Northeastern Haor Region of Bangladesh: Insights from CMIP6 Multi-Model Ensemble Projections
Authors: Kamruzzaman Mohammad , Islam HM Touhidul , Rahman Md. Sazzadur , Ahmed Sharif , Lipi Liala Ferdousi , Khan Md. Arifur Rahman , Tran Lam-Son Phan , Hossain AMK Zakir
Published: March 2024

Northeastern Bangladesh is highly vulnerable to the intensifying impacts of climate change, with extreme climatic events posing a significant threat to rice production. This study examines the projected changes in five key thermal stress indices and heavy rainfall during the rice reproductive phase using 15 global climate models (GCMs) under moderate (SSP2-4.5) and high (SSP5-8.5) emission scenarios. Statistical downscaling and bias correction techniques were employed to generate daily climate data for rainfall, maximum temperature (Tmax), and minimum temperature (Tmin). The Mann–Kendall (MMK) test was applied to identify future trends in these extreme events. The results reveal a substantial decrease in cold stress indices, with three consecutive cold days (CCD3) and six consecutive cold days (CCD6) projected to decline by approximately 9 days. Notably, heat stress indices are anticipated to increase, with hot days (HD) and consecutive hot days (CHD) rising by 18 and 11, respectively. Heavy rainfall days (HR) did not exhibit significant changes. The projected rise in temperatures above 35°C during the rice reproductive phase, encompassing critical stages such as flowering, gametophyte development, anthesis, and pollination and fertilization, suggests adverse consequences for rice yields. These findings underscore the urgency of implementing specific adaptation and mitigation measures to minimize potential yield losses in a future characterized by elevated temperatures. Such measures may include cultivating heat-tolerant rice varieties, adjusting planting windows, and diversifying rice varieties with varying growth durations.
Novel genomic variants influencing methotrexate delayed excretion in pediatric patients with acute lymphoblastic leukemia
Authors: Choi Jung Yoon , Kwon Hoshik , Kim Hyery , Hong Kyung Taek , Ma Youngeun , Koh Kyung-Nam , Yun Sunmin , Yoo Keon Hee , Song Sang Hoon , Kang Hyoung Jin , Im Ho Joon , Kim Ju Han
Published: March 2024

Background
Methotrexate (MTX) is the primary drug used in the treatment of pediatric acute lymphoblastic leukemia (ALL). However, some patients exhibit delayed excretion of high-dose (HD) MTX, which induces severe nephrotoxicity. We sought to identify relevant mutations associated with delayed excretion of HD-MTX in pediatric patients with ALL.
Methods
Whole-exome sequencing of germline DNA was performed in 51 Korean pediatric patients with ALL. A total of 341 HD-MTX infusion data points from 51 patients were analyzed. Correlations between peak serum MTX levels at 24 h and toxicity markers were assessed. Analyses were performed to identify variants affecting delayed MTX excretion.
Results
The 24 h MTX level strongly correlated with the subsequent Cr level. Moreover, rs2229866 in CNTN2, rs200687372 in MTMR9, rs777260512 in POLI, rs16954698 in PKD1L2, rs117765468 in NSMCE1, and rs1800956 in ENG were identified as candidate variants associated with delayed MTX excretion. In particular, ENG rs1800956 was significantly associated with delayed MTX excretion in all analyses.
Conclusions
This is the first whole-exome sequencing-based analysis of delayed MTX excretion in pediatric patients with ALL. Six candidate variants were identified, and ENG rs1800956 was identified as a novel and promising variant affecting delayed MTX excretion. Therefore, further analyses and validation are required.
A protective causal relationship between morphine and colorectal cancer: a two-way Mendelian randomization study
Authors: Deng Qing , Yu Yi fan , Yu Cheng yang , Luo Hui yan , Gong Chun , Wang Xiong Wen
Published: March 2024

Purpose: The relationship between morphine and colorectal cancer has been controversial. To address this controversial issue, we examined the relationship between morphine and colorectal cancer.
Methods: The causal relationship between morphine and colorectal cancer was investigated through Mendelian randomization (MR). Analysis was conducted using the publicly available GWAS database. First, single nucleotide polymorphisms (SNPs) strongly associated with morphine exposure factors were screened. Then the causal relationship between morphine and colorectal cancer was analyzed using inverse variance weighted (IVW), weighted median, and MR Egger methods. Finally, tests for sensitivity, heterogeneity, and pleiotropy were performed to ensure the stability and reliability of the results.
Result: The IVW analysis revealed a protective causal relationship between morphine use and colorectal cancer (odds ratio [OR] = 0.30, 95% confidence interval [CI]: 0.10-0.87, p = 0.03).
Conclusion: We provide evidence of a possible protective causal relationship between morphine and colorectal cancer. Further validation through larger clinical randomized studies and more advanced methods is needed.
Clinical diagnostic value of tRF-24-6VR8K09LE9 and its identification as a novel tumor suppressor in gastric cancer
Authors: Tang Yelan , Qi Qianyi , Feng Wei , Ju Shaoqing , Jing Rongrong , Zong Wei
Published: March 2024

Background
One of the most common gastrointestinal tumors is gastric cancer (GC), which has a high lethality and a poor prognosis. Traditional markers are relatively limited in detecting the development and prognosis of GC. Recently, it was discovered that mature tRNAs, which are expressed differently in a variety of malignancies, give rise to a novel class of tRNA-derived small RNAs (tsRNAs).
Methods
In this study, we investigated the role of short RNAs produced from tRNA in GC and possible therapeutic uses. We performed the detection of three tsRNAs using the tsRFun database, and then the TCGA database and quantitative real-time PCR (qRT-PCR) were applied to validate them. Sanger sequencing, agarose gel electrophoresis, and several freeze-thaw experiments have been utilized to assess its performance at room temperature. The association between tRF-24-6VR8K09LE9 and clinicopathological features was investigated by the Chi-square test. Diagnostic effectiveness is assessed by Receiver operating characteristic curves (ROC). Furthermore, mechanistic studies were performed to verify the effects of tRF-24-6VR8K09LE9 in GC.
Results
In GC, tRF-24-6VR8K09LE9 is low expressed. The Chi-square test displayed that tRF-24-6VR8K09LE9 was highly related to differentiation grade (P = 0.029), T-stage (P = 0.036), lymph node status (P = 0.036), TNM staging (P < 0.0001), and neurological/vascular invasion (P = 0.033), and the ROC curve indicated that tRF-24-6VR8K09LE9 is more effective than the current diagnostic markers for GC. Furthermore, mechanistic studies verified that upregulation of tRF-24-6VR8K09LE9 inhibited the development of GC.
Conclusions
tRF-24-6VR8K09LE9 can serve as a molecular marker for early GC. tRF-24-6VR8K09LE9 may be a tumor suppressor, and high levels of tRF-24-6VR8K09LE9 GC inhibit the invasion and migration.
Haemodynamic Effect of Dexmedetomidine During Pediatric Kidney Transplantation: A Single-Center Retrospective Study
Authors: Monteil Matéo , Chenouard Alexis , Roussey Gwenaëlle , Bernardon Rémi , Gaultier Aurélie , Porcheret Florence
Published: March 2024

Background Dexmedetomidine is increasingly used for its hemodynamic stability property during general anesthesia. However, there is no data on pediatric kidney transplant recipients (pKTR). Our study investigates the hemodynamic effect of perioperatively administered dexmedetomidine in pKTR. Methods Between 2019 and 2023, all pKTR below 18 years were studied retrospectively at Nantes University Hospital. Intraoperative hemodynamic status was compared between patients who had received dexmedetomidine during kidney transplantation (DEX group) and patients who had not (no-DEX group). Mean arterial pressure (MAP) and heart rate (HR) were monitored throughout the duration of anesthesia and compared. Graft function was assessed by creatinine levels and Glomerular Filtration Rate (GFR) at specific time points. The use of fluid and vasoactive drugs peri-operatively and within 24 hours after surgery was also studied. Results 38 patients were included, 10 in the DEX group et 28 in the no-DEX group. Intraoperative HR was similar between the two groups; however, MAP was significantly higher (mean difference 8, standard deviation [SD: 2–14] mmHg,p = 0,034) in the DEX group. No differences were found regarding the use of fluid and vasoactive drug therapy between groups. Glomerular filtration rate at one month was significantly higher in DEX group (p = 0,009). Conclusion Children receiving intraoperative dexmedetomidine during a KT presented higher perioperative MAP compare to children receiving other sedative agents. DEX group also showed better graft function at one month. The direct impact of dexmedetomidine on immediate post-operative graft function in pTKR should be studied in a prospective multicenter randomized study.
Intraoperative radiotherapy after neurosurgical resection of brain metastases as institutional standard treatment– Update of the oncological outcome form a single center cohort after 117 procedures
Authors: Kahl Klaus-Henning , Krauss Philipp E. , Neu Maria , Maurer Christoph J. , Schill-Reiner Sabine , Roushan Zoha , Laukmanis Eva , Dobner Christian , Janzen Tilman , Balagiannis Nikolaos , Sommer Björn , Stüben Georg , Shiban Ehab
Published: March 2024

Purpose: Stereotactic radiotherapy (SRT) is the predominant method for the irradiation of resection cavities after resection of brain metastases (BM). Intraoperative radiotherapy (IORT) with 50kV x-rays is an alternative way to irradiate the resection cavity focally. We have already reported the outcome of our first 40 IORT patients treated until 2020. Since then, IORT has become the predominant cavity treatment in our center due to patients´ choice.
Methods: We retrospectively analyzed the outcomes of all patients who underwent resection of BM and IORT between 2013 and August 2023 at Augsburg University Medical Center (UKA).
Results: We identified 105 patients with 117 resected BM treated with 50kV x-ray IORT. Median diameter of the resected metastases was 3.1cm (range 1.3 – 7.0 cm). Median applied dose was 20Gy. All patients received standardized follow-up (FU) including three-monthly MRI of the brain. Mean FU was 14 months, with a median MRI FU for patients alive of nine months. Median overall survival (OS) of all treated patients was 18.2 months (estimated 1-year OS 57.7%). The observed local control (LC) rate of the resection cavity was 90.5% (estimated 1-year LC 84.2%). Distant brain control (DC) was 61.9% (estimated 1-year DC 47.9%). Only 16.2% of all patients needed WBI in the further course of disease. The observed radio necrosis rate was 2.6%.
Conclusion: After 117 procedures IORT still appears to be a safe and appealing way to perform cavity RT after neurosurgical resection of BM with low toxicity and excellent LC.
Statistic Deviation Mode Balancer (SDMB): A novel sampling algorithm for imbalanced data
Authors: Alimoradi Mahmoud , Daliri Arman , Zabihimayvan Mahdieh , Sadeghi Reza
Published: March 2024

Proper grouping in classifier algorithms is a critical element of supervised learning. The first step in this is to have the correct data. Data that has a problem is worse than not having it. One of the biggest problems inherent in natural data is its imbalance. For a classifier algorithm to achieve its best performance, the first step is to fix the problem of data imbalance. To work with real datasets, the first step is to balance the data. The main problem with existing algorithms is to duplicate minority data and generate data that make outlines part of the primary data. The Statistic Deviation Mode Balancer (SDMB) algorithm solves this problem by making samples that adhere to the original data structure. Our proposed algorithm generates data that is very similar to the original data with the help of standard deviation and the amount of minor data mode and moving away from the majority part. Using these two parameters, the SDMB algorithm avoids Outlier data and generates clean data. The output of this algorithm is a balance datasheet that helps classifier algorithms learn the best way from the data. Different classifier algorithms with entirely different methods have been tested to prove this point. First, we balanced the different datasets with our method. Then, with varying classifier algorithms, we compared it with other existing algorithms. This experiment showed that our proposed algorithm is superior to other competitors and can be used in the work process of real datasets.
Repeat Peptide Receptor Radionuclide Therapy in Neuroendocrine Tumors: A NET Center of Excellence Experience
Authors: Grewal Udhayvir S , Loeffler Bradley T , Paschke Alexander , Dillon Joseph S. , Chandrasekharan Chandrikha
Published: March 2024

Introduction:
The available data for the safety and efficacy of repeat Peptide Receptor Radionuclide Therapy (PRRT) are almost exclusively from European centers. We present an updated experience with repeat PRRT in a cohort of US patients with neuroendocrine tumors (NETs) at our NET center of excellence.
Methods
We used our single-center longitudinal NET registry to identify patients who had been previously treated with at least one dose of PRRT (PRRT 1, either 177Lu DOTATATE or 90Y DOTATOC) and following radiographic disease progression (per RECIST 1.1 criteria) were re-treated with a second course of PRRT (PRRT 2). We reviewed patient, tumor and treatment characteristics, objective response rates and toxicities after PRRT 1 and PRRT 2.
Results
A total of 11 patients were included in the analysis. 45.5% (5/11) patients received 177 Lu DOTATATE PRRT only, both for PRRT1 and PRRT 2, while 54.5% (6/11) patients received 90Y DOTATOC PRRT for PRRT1. At first restaging scan after PRRT2 (3–6 months), 18.2% (2/11), 36.4% (4/11) and 27.3% (3/11) patients had PR, SD and PD respectively; 2/11 patients (18.2%) died before first restaging scan. Median PFS for PRRT1 (n = 11) was 25.4 months and median PFS (n = 10) for PRRT2 was 13.1 months (p = 0.0001). We did not find a statistically significant difference between the occurrence of short and long-term hematological toxicities as well as renal toxicity after PRRT1 and PRRT2.
Conclusion
We show that repeat PRRT may benefit select patients and has an acceptable safety profile. In our cohort, PFS was significantly lower after PRRT2 as compared to PRRT1.
Climate Change Projections of Potential Evapotranspiration for the North American Monsoon Region
Authors: Shamir Eylon , Mendoza-Fierro Lourdes , Karimi Sahar Mohsenzadeh , Pelak Norman , Chang Hsin-I , Castro Christopher
Published: March 2024

We assessed future projected changes in terrestrial evaporative demand by calculating Potential Evapotranspiration (PET) for the North American Monsoon region at the Southwest U.S. and Mexico. The PET projections were calculated using the daily Penman-Monteith equation and the terrestrial meteorological variables needed for the equation (i.e. minimum and maximum daily temperature, specific humidity, wind speed, incoming shortwave radiation, and pressure) were available from the North American – CORDEX initiative. We used six dynamically downscaled projections of three CMIP5 GCMs forced with RCP8.5 emission scenarios (i.e. HadGEM2-ES, MPI-ESM-LR, and GFDL-ESM2M), each was dynamically downscaled to ~ 25 km by two RCMs (i.e. WRF and regCM4). All terrestrial annual PET projections showed a statistically significant increase when comparing 1986–2005 to 2020–2039 and 2040–2059. The regional spatial average of the six climate models projected an increase in the annual PET of about + 4% and + 8% for 2020–2039 and 2040–2059, respectively. The projected average 20-year annual changes over the study area range respectively for the two projection periods were + 1.4%-+8.7% and + 3%-+14.2%. The projected annual PET increase trends are consistent across the entire region and for the 6 climate models. Higher annual changes are projected in the northeast part of the region, while smaller changes are projected along the pacific coast. The main drivers for the increase are the projected warming and increase in the vapor pressure deficit. The projected changes in PET, which represent the changes in the atmospheric evaporative demand, are substantial and likely to impact vegetation and the hydrometeorological regime in the area.
Evaluation of Sentinel-1 Satelite-based Soil Moisture Products for Runoff Modelling with Karst Formation Characteristics
Authors: Mawandha Hanggar Ganara , Pratama Afinafghani Duta , Ghifari M. Ramadhan Al , Hanifah Nasywa Hanin , Nursafa Issiami , Lestari Prieskarinda , Oishi Satoru
Published: March 2024

Soil moisture content is a crucial factor in hydrological studies as it helps to determine the rainfall and runoff response in the catchment. Land use, particularly cropping, can have a significant effect on soil moisture content. Hilly topography with karst features is more prone to flooding and soil erosion due to its low water holding capacity. Remote sensing technology has recently been applied to agriculture and disaster management. The aim of this research is to identify soil moisture characteristics in karst formations for runoff estimation using remotely sensed imagery from Sentinel-1. Soil moisture is calculated using the Topp model equation based on the soil dielectric value obtained from the Dubois model. By using different types of land use and soil moisture data from Sentinel-1, CN values can be generated and then used to estimate runoff. The results of the study show that extracting soil moisture information from Sentinel-1A with VV polarisation for karst areas is still challenging due to the high bias. The Sentinel-1 satellite soil moisture products could provide a real-time CN value that can be integrated with the rainfall runoff model. This research highlights the importance of monitoring soil moisture to determine CN values for flood mitigation.
Significant value of p53 accumulated in Invasive Ductal Breast Carcinoma
Authors: Baccouche Sami , Rebai Ahmed , Frikha Mounir , Daoud Jamel , Jlidi Rachid , Gargouri Ali
Published: March 2024

Background
The presence of a functional p53 protein is a key factor for the appropriate suppression of cancer development. The tumor suppressor p53 accumulates under stressful conditions, such as DNA damage, heat shock, hypoxia, and/or proto-oncogene activation, although conflicting reports exist on its transcriptional activity. A loss of p53 activity, by mutations or inhibition, is often associated with human malignancies. This work investigated the significant value of p53 accumulated in IDBC (Invasive Ductal Breast Carcinoma) and at the same time tries to arise different supports of this value.
Results:
To ensure this objective, we referred to two types of statistical analysis, the chi-square and logistic regression analysis. They confirmed the poor prognosis of p53 accumulated in IDBC (β* = -0.456 with p=0.00001) and showed that the independent variables (MDM2, BCL2, BAX and ER) formed an interesting model to explain the significant value of p53 accumulated in the IDBC. The predictive value of the model including the four biomarkers is AUC=93.5%, showing that if we take the expression status of the four biomarkers, we can deduce the status of p53 with a reliability of 93.5%.
The residual term, representing 6,5% and involved in this significant value, corresponds to intrinsic modifications of p53: alterations of the TP53 gene, p53-oncoprotein interaction or cytoplasmic sequestration. In fact, following the IHC results of three different antibodies that recognize wild type or mutant p53, we examined the status of polymorphism 72, which may inform LOH (loss of heterozygozity). We found LOH associated with TP53 mutations in the context of down-regulated p53 target genes revealed by IHC. Although wild type in some cases, p53 loses its transcriptional activity; this may be due to oxidation of cysteine residues in the core domain, either iSAPP interaction or its cytoplasmic sequestration.
Conclusion: P53 accumulated in IDBC had a significant value and the etiological factors of this value should be target for effective therapy.
Does the environmental impact of banks affect their financial performance?
Authors: Bressan Silvia
Published: March 2024

We study empirically the environmental impact of banks, i.e. the negative externality on the environment and the society deriving from the use of a natural resource or the emission of a pollutant. We find that environmental “impact ratios”, i.e. environmental damage costs in proportion to total revenues, are negatively correlated with bank profitability. Furthermore, banks with a stronger impact on the environment are valued less by equity market investors and pay less cash to share- holders. Among environmental categories, potential damages from greenhouse gas emissions or waste seem to be especially severe. We deliver important insights for banks´ environmental management. If bankers would be able to address businesses and practices to be more renewable and lower in their emissions, they could im- prove both the operating as well as the market performance. Thus, firms would be financially more stable, and could react smoothly to the recent introduction of stricter and onerous environmental regulations.
Image Colourization using Generative Adversarial Networks
Authors: Majumdar Soumya
Published: March 2024

Over the last decade, the process of automatic image colouration has been of significant interest for several application areas, including the restoration of aged or degraded images. Image colorization is a challenging task in computer vision that involves adding realistic colours to greyscale images. Traditional methods rely on handcrafted rules and heuristics, which can lead to inconsistent and inaccurate results. Generative adversarial networks (GANs) offer a promising solution for this problem by learning to generate realistic colour images from greyscale inputs. In this paper, we review the state-of-the-art techniques for image colorization using GANs. We discuss different architectures and loss functions used in GANs for colorization, as well as their advantages and limitations. We also provide an overview of the datasets used for training and evaluation and the metrics used for measuring the performance of the models. Finally, we discuss the potential applications of GAN-based colouration in various domains, such as art, photography, and medical imaging. Overall, we show that GAN-based approaches offer a powerful and flexible framework for image colorization, with the potential to revolutionize the way we perceive and manipulate visual content.
Investigation into gender disparity and students’ performance in geometry: a quasi-experimental study of final year Male and Female students’ geometry learning using Van Hiele’s Model
Authors: Enoch Suglo Kabinaa
Published: March 2024

There are mixed findings and views about gender gap in mathematics learning. Whiles some studies have revealed that only men have the capacity to dominate in mathematics as compared to their female counterparts, other studies have found that women have the potential to even outperform their male counterparts in mathematics. There continue to be growing uncertainty regarding male and female students learning and performance in mathematics. This current study however was designed to explore the nexus between gender and geometry performance in respect to male and female students’ geometry learning and performance. The study employed a one-group quasi-experimental design with a population and sample size of 360 and 186, respectively. Stratified and random sampling processes were used to select the sample members. Data for the study were collected using a questionnaire (Google form) and a Geometry Achievement Test (Pretest and posttest). Data analysis was done using SPSS’s descriptive procedures and a paired sample t-test. The study found that: 1) there was a significant difference between male and female students academic performance in geometry, p(<.000). 2) The study also found that the use of Van Hiele’s geometry thinking model contributed to an improved geometry learning and performance. The study therefore recommended that teachers should make use of the Van Hiele’s model in teaching geometry, give equal support or pay equal attention to both male and female students in the classroom during teaching and learning.
Time saved is time earned: Implementation of an agile workflow system in a high-volume radiation oncology centre Workflow optimization in radiation oncology
Authors: Chufal Kundan Singh , Ahmad Irfan , Miller Alexis Andrew , Umesh Preetha , Dwivedi Alok , Bhatia Kratika , Gairola Munish
Published: March 2024

Aims and Objectives:
To evaluate operational efficiency gains when utilizing an agile digital workflow system (DWS; OncFlow®) in the Radiation Oncology clinic over standard workflow (SW).
Materials and Methods
Two Radiation Oncology teams in the same institution, one using DWS and the other SW, were prospectively assessed to compare the following operational parameters: consultation waiting time, communication errors, and data retrieval. We employed non-parametric tests and an unpaired t-test for statistical analysis.
Results
Digital workflow patients experienced a median consultation waiting time of 5.5 minutes (95% CI: 4.7–6.3) compared to 17.9 minutes (95% CI: 14.2–21.6) in the standard workflow, with the difference being significant (p < 0.0001). Communication-related incidents each month were significantly lower in the DWS group, with a median of 1 incident (range: 0–3) compared to 4 incidents (range: 1–5) in the SW (p < 0.001). Planned data retrieval was also considerably faster with DWS.
Conclusion
Digital workflow systems significantly reduce consultation waiting times and communication errors, enhancing efficiency in the Radiation Oncology clinic. Faster data retrieval also reduced research turnaround time. Broader application in more diverse working environments is warranted.
Equisetum diffusum methanolic extract attenuates arthritis through the modulation of key inflammatory biomarkers like COX-2, TNF-α, IL-6, PPAR-γ and Iκβ expression in Adjuvant-induced rats.
Authors: Sarkar Sourav , Modak Debabrata , Roy Sudipta Kumar , Ashraf Gouhar Jahan , Chakrabarty Ayan , Sahu Ranabir , Bhattacharjee Soumen
Published: March 2024

Rheumatoid arthritis (RA) is a chronic inflammatory disease associated with subsequent damage to the bone joints. Equisetum diffusum D. Don, from the Equisetaceaefamily, is a native pteridophyte species of the sub-Himalayan region of India and has been reported to have a diverse array of pharmacological properties. The present research is focused on determining the anti-arthritic potential of E. diffusum whole plant methanolic extract (EDME) in adjuvant-induced arthritic rats. Treatment with EDME significantly restored paw-edema, arthritic scoring, and normal body weight. EDME treatment also normalized the haematological, biochemical, radiological, and histological status when compared to the arthritic control rats. The methanolic extract significantly (p<0.05) attenuated arthritis progression by downregulating the gene expression of pro-inflammatory mediators, like COX-2, TNF-α, IL-6, and upregulating the expression of anti-inflammatory mediators PPAR-γ, Iκβ in a dose-dependent manner. Significantly, EDME also reduced the serum concentration of COX-2, TNF-α, and IL-6 compared to arthritic control rats (p<0.05). The treatment with EDME also normalized the oxidative stress level in liver by restoring the GSH level, CAT and SOD activities and reducing the elevated MDA level. HPTLC and LC-MS/MS analyses of EDME confirmed the presence of potent polyphenols (chlorogenic acid, 4-hydroxycinnamic acid) and flavonoids (kaempferol), thereby suggesting the anti-arthritic property of the plant. All our findings established the anti-arthritic potential of E. diffusum extract in chronic arthritis model on a strong ground.
Seismic analysis of a multi storied steel building provided with different types of damper and base isolation
Authors: Patil Aishwarya Yogesh
Published: March 2024

This manuscript research presents the design of steel building and analysis of different damper and base isolation systems at various seismic zone for a multi-storied steel framed building (MSSB). Steel buildings are easy to build and gives more strength, also after demolish there are scrap value so ties more economical. Base isolation provides structural safety and also safety and security for people and properties in the building. Base isolation is also used for the retrofit of the historic buildings. In the present manuscript work done on, Seismic analysis of G+10 multi storied steel building with and without dampers (viscous damper and friction damper) and base isolation system (friction isolation and lead plug bearing). In this types of seismic provision which one is more suitable according to seismic zone for stabilization of steel building analyzed. In this work used seismic zone II, zone III, zone IV and zone V by using ETABs software analysis carried out. Found the optimum damper and base isolation combination effect in the steel building and analysis result of responses (viz. storey drift, storey displacement, base shear).
Rare Manifestations of Gastric Cancer: Leptomeningeal Carcinomatosis Without Other Metastases
Authors: Alwaw Ricarda , Ammouri Yara , Allabwani Abdalqader , Yazbek Majd , Alhussin Mohammad , Alrefaei Bayan
Published: March 2024

Neurovascular conditions in cancer patients can result from the tumor itself, cancer treatment side effects, hypercoagulability, or a weakened immune system. CVT is common in patients with hematological malignancies, especially leukemia. Leptomeningeal disease (LMD) is a rare but devastating complication in advanced cancer. A 53-year-old man presented with a 20-day history of headaches, right-sided weakness, and seizures. Examination revealed normal cranial nerves, weak upper (3/5) and lower (2/5) right limbs. CSF analysis showing 16 lymphocytes/µL, protein of 20 mg/dL, and glucose of 42 mg/dL. Cytologic examination was positive for adenocarcinoma cells. Upper GI endoscopy revealed a gastric ulcer with malignant features. Leptomeningeal carcinomatosis (LM) is the harmful invasion of the pia mater and arachnoid membrane, occurring in 5–15% of cancer patients. The average survival time is 2 to 6 months, with poor prognosis associated with age over 50, poor performance status, short interval between cancer diagnosis and LM, primary lung cancer or melanoma, and lack of treatment response. Gastric cancer, the fourth most common tumor and second cause of death worldwide, rarely metastasizes to the meninges (0.1–0.69%). This case describes a patient with gastric adenocarcinoma who developed LM, an unusual manifestation, without other metastases.
The Significance of the Handshake Based on Religious and Social Perspectives (Analytical Study of Yusuf al-Qardhawi and Petter L. Berger)
Authors: Ramdani Acep Dani , Noorhidayati Salamah , Rohandy Fajar , Apriani Laelati Dwina
Published: March 2024

A habit that exists in the community is a culture that is carried out continuously in a descending way so that it becomes an important part of people's social life. Like shaking hands is a habit that almost everyone has, regardless of ethnicity, race, religion, age, or social status. shaking hands or shaking hands becomes a symbol of the bond of a social relationship, whether business relations, friendship, kinship, and others. However, Islam as a religion that maintains benefit has a legal procedure for shaking hands with other people. Shaking hands between men and women who are not mahrams is a problem in society. some people believe in his permissibility, and others believe in his prohibition. This study aims to discuss handshakes from religious and social perspectives. This research method uses a qualitative type with secondary sources, namely books, theses, dissertations, and journals related to this research. Furthermore, this study applies content analysis as a means to examine the collected data so that conclusions can be drawn. This research results from a handshake analysis from religious and social perspectives with Yusuf al-Qardhawi’s theoretical approach and Peter L. Berger’s theory. This study concludes that there is a correlation between Yusuf al-Qardhawi’s theory of the handshake and the social construction analysis of Peter L. Berger.
A Referential Interpretation al-Jaryī wa al-Inṭibāq: Approach (Tafsīr Taṭbīqī) for Digging The Inner Meaning of al-Qur'an.
Authors: Kerwanto Kerwanto
Published: March 2024

Some important criteria that must be considered by the commentator in determining the inner (esoteric) meaning of the Qur'an are that it must not conflict with the literal text, mutawatir hadiths and important religious principles (dharuriyāt ad-dīn). Once the requirements that must be met in the interpretation are so strict, not a few products of isyari interpretation (Sufi interpretation) are considered deviant and trapped in tafsir bi al-ra’yī al-madzmum (despicable interpretation). Therefore, it is important to carry out several in-depth reviews of various approaches and rules of interpretation that can be used as a medium for revealing and explaining the inner meaning of the Qur'an.

            In this article, the author tries to clarify the important position of the rule of al-jaryī wa al-Inṭibāq in the interpretation of the Qur'an, which is very likely in some cases not paid attention to by some commentators. For the author, this rule can be a bridge in determining the validity of the inner meaning of the Qur'an because the main element of this rule is the hadiths that are related to the context of the nuzūl verse. The main working principle of this rule is to try to apply certain references intended by the verses of the Qur'an to several different individuals at different times and places with the context of the initial nuzul of the verse. This rule seeks to find new meanings from the general concept of the verse which is abstracted from hadith data that is related to the context of its nuzul.
ARENA OF PUBLIC DOMINANCE SEEING THE TRANSFORMATION OF THE SOCIAL FUNCTION OF ISLAMIC ART JEDORAN TULUNGAGUNG
Authors: Winanti Risa , Afiyanto Hendra
Published: March 2024

This study aims to analyze the existence and sustainability of Jedoran art in Tulungagung, a city in East Java. Jedoran art was brought to Tulungagung by Sunan Kalijaga in the 16th century and has a long history. However, a big question arises: Does Jedoran art currently have the same social function as when it first appeared, or is this the result of adaptation of the old Jedoran art to fit in with new cultures and traditions? This research was conducted in Tulungagung because it is a Mataram Islam territory with a relationship to the Yogyakarta Sultanate. The researcher used historical and ethnographic methods as well as Foucault discourse analysis to understand how Jedoran art has developed according to the discourse that appears in every era. The results show that the sustainability of Jedoran art is not separated from the ability of Jedoran artists to read and adapt to the discourse that develops in accordance with changes in time. In addition, this adaptation is actualized through the transformation of the social function of Jedoran art according to the discourse that appears in every era.
THE LAW OF PRACTICING DHAIF HADITH IN FADHAIL A'MAL
Authors: Rambe Mgr Sinomba , Husna Jannatul , Waharjani Waharjani
Published: March 2024

The position of hadith in Islamic law is to strengthen and elaborate the laws and rules contained in the Koran, but in this era there are still many who do not understand the types of hadith, which are strong, weak, false, and even not allowed to be practiced. Because of this, a strong and significant understanding is needed regarding the law of practicing dhaif hadiths in Fadhail al-Mal. This study aims to identify the meaning of dhaif hadith and the law of practicing it in fadhail amal in everyday life. This study combines qualitative research with literature review research. All of the data sources that the researchers surveyed included several scientific articles, library books, and other sources relevant to the law of practicing dhaif hadith in fadhail amal. The results of the study show that the law of practicing dhaif hadiths in fadhilah charities is very permissible, provided that one first understands the quality and quantity of these hadiths, both in terms of the narrators and the line of the sanad. There are types of hadiths that may be practiced, and there are also types of daif hadiths that are forbidden to be profitably practiced in charity fadhail. in the sense that a daif hadith can be used as proof and argument for a practice, provided that the level of the hadith does not belong to a shadid hadith (very weak), let alone a maudlu or fake hadith.
MAN'S RELATIONSHIP WITH NATURE IN THE TAFSIR AL-IBRIZ AND AL-MISHBAH
Authors: Rohman Ali Abdur , Ahsan Moh. Wafiq Faulal
Published: March 2024

This study aims to compare the interpretations of Al-Ibriz and Al-Mishab in relation to the relationship between humans and nature. The formulation of the problem raised by the author is: "How is the relationship between humans and nature in Al-Ibriz and Al-Mishbah and what is the difference between the two?" The analytical method used is muqaran. With the type of literature studied, the author makes Tafsir Al-Ibriz and Tafsir Al-Mishbah the primary sources and literature in the form of books and articles related to themes the secondary sources. The results of this study are, first, that the relationship between humans and nature appears in actions that lead to the destruction of nature, namely QS. Al-A'raf: 56. In Tafsir al-Ibriz, acts of destruction are defined as acts of shirk and immorality. Whereas in Tafsir Al-Misbah, vandalism is an act that exceeds the limit, both in terms of its physical, spiritual, and natural surroundings. Second, in QS. Yasin: 33-35 of Tafsir Al-Ibriz, it is stated that humans are ordered to maximize the role of reason in preserving nature as a form of gratitude to Allah SWT. Whereas in Tafsir Al-Mishbah, humans play a direct role in preserving nature, the essence remains Allah SWT, who determines.
TO PREDICT THE NEED FOR AMPUTATION IN DIABETIC FOOT ULCER USING SVS - WIFI SCORING SYSTEM
Authors:   PG Rsident General Surgery Under The Guidance Of., Chandiramani Shibani , Suraj Lisha ,   Professor and Hou General Surgery.
Published: March 2024

Analysis of svs wifi scoring as a predictor for amputation in diabetic foot ulcer dr. Shibani chandiramani, dr lisha suraj department of general surgery mahatma gandhi medical college, navi mumbai introduction : Critical limb ishchemia in diabetic patients is defined as a clinical syndrome of ischemic pain at rest and/or ischemic tissue loss such as non healing ulcers or gangrene for more than 2 weeks with ankle pressure of < 40mmhg. It differs from acute limb ischemia which is sudden loss of perfusion typically due to embolus or in situ thrombus. The svs wifi scoring system stratifies cli on the basis of perfusion , extent of wound and superadded infection to provide a composite score wich guides further management and predicts final prognosis. Aim:- to predict the need for amputation in diabetic foot ulcer using svs wifi scoring. Objectives:- To study the predictive role of svs wifi scoring system in diabetic foot ulcers undergoing amputation material and methods :- the subjects were 30 patients with diabetic foot ulcers, gangrene, wound presenting to general surgery, diabetic clinic or vascular surgery at mgm medical college , navi mumbai. Wifi scring of diabetic foot ulcers were done at the time of presentation after obtaining consent from the patient/ relatives.the wifi categories according to risk of limb loss were identified with endpoint being major/ minor amputations. Result:- The composite wifi score (a summmation of wound , infection and ischemia sub-scores) was a good predictor of need for amputation in diabetic ulcer patients.
TRAINING IN MANAGEMENT SCIENCES AS A COMPLEMENT FOR PROFESSIONALS IN HUMAN MOVEMENT SCIENCES IN COSTA RICA
Authors: Ali Monge Poltronieri Steve
Published: March 2024

Today, rapid, and continuous business growth requires employees who have a deep understanding of the market and can make timely decisions, so it is necessary for employees to receive specific training for this. The objective of this article is to determine the level of training in business administration and management that specialists in human movement sciences have in Costa Rica. A quantitative investigation was carried out in which 108 individuals related to the sciences of human movement participated, who completed the Training Needs Questionnaire. The results of the research show that the participants mostly have little training in entrepreneurship and administration, but they recognize their interest in receiving training in this area.
Phenological, growth, and yield responses of sweet corn to elevational air temperatures in the humid tropics
Authors: Sudjatmiko Sigit , Chozin Mohammad
Published: March 2024

Temperature plays a determinant role in the rate of plant metabolic activities and, accordingly, dictates the plant's phenological stages, growth, and productivity. The objective of this study was to evaluate the phenological, growth, and ear yield behavior of ten sweet corn hybrids in response to elevational temperature changes in the humid tropics. Seeds of ten hybrids were grown in three elevations (coastland, midland, and highland). Results show that the hybrids belonged to the same maturity group with comparable accumulated growing degree days, but they varied in green ear yield, harvest index, and heat use efficiency. It was also found that higher elevations lead to longer plant growth and fewer growing degree-day requirements, resulting in increased in biomass accumulation for ear and overall vegetative growth but more efficient in the heat use. These findings will be useful as a guide for crop management scheduling, including fertilizers application, pest control, diseases control, and weed control, to maximize sweet corn yield at different elevations in the humid tropics.