bluuebunny/crossref_metadata_2025 huggingface dataset:
The GLORIA adherence subproject: problems and randomization mistakes
Authors: Hartman Linda , Kok Marc R. , Molenaar Esmeralda , Griep Ed N. , van Laar Jaap M. , van Woerkom Jan Maarten , Allaart Cornelia F. , Raterman Hennie G. , Ruiterman Yvonne P. M. , Voshaar Marieke J. H. , Redol João , Pinto Rui M. A. , Klausch L. Thomas , Lems Willem F. , Boers Maarten
Published: October 2021

Medication adherence, which is the extent to which patients take their medication as prescribed, is essential in treating chronic inflammatory diseases such as rheumatoid arthritis (RA). Therefore, we nested a subproject in the two-year multicenter Glucocorticoid Low-dose Outcome in Rheumatoid Arthritis (GLORIA) trial to add a low-dose prednisolone (5 mg/day) or placebo to the standard care in older people (≥65 years) with RA. Adherence was measured with an electronic monitoring cap that recorded bottle openings in all patients. In the subproject, we performed an adherence intervention with an advanced cap that could communicate with an application on the smart device via Bluetooth. We randomized patients with a smart device to receive or not to receive adherence reminders on the smart device for three months. Multiple problems emerged that precluded an answer to the research question: sample size (overly optimistic estimates of older patients with a smart device), logistic issues (availability of smartcaps, data extraction), randomization and treatment allocation errors (despite training of personnel), and low quality of the data in the intervention group (hardware failure, discovered too late because data was read in batches). For future trials planning to include a subproject, we recommend keeping it simple, starting with a field test before the actual study starts, and monitoring data from the beginning of the study.
Oral Dietary Supplements Use among Healthcare Workers during the COVID-19 Pandemic in Malaysia
Authors: Lee Heoy Teng , Loh Hong Chuan , Ramlee Siti Nur Liyana , Looi Irene
Published: October 2021

Healthcare workers (HCWs) must be aware of the latest data supporting or refuting the use of oral dietary supplements (ODS) in order to disseminate evidence-based health information and help patients make informed decisions. Nevertheless, there is relatively scant data on the prevalence of dietary supplement use among HCWs, the types of dietary supplements recommended to patients by HCWs, and their reasons for recommending these products, particularly during the COVID-19 outbreak. This study examined the prevalence of ODS use among surveyed HCWs, considered the types of ODS used and recommended by those HCWs, identified the reasons given by those HCWs for using or not using ODS, and determined whether those HCWs were recommending or not recommending ODS to their patients during the COVID-19 pandemic. This cross-sectional study targeted all HCWs working at a district hospital in Malaysia and was conducted via a self-administered online survey. The survey revealed that 67.3% of HCWs did not recommend ODS for patient use during the pandemic, despite 55.3% of HCWs reported personal use of ODS during the pandemic. Type of HCWs (P=0.001), monthly household income (P=0.019), prior ODS use (P<0.001) and recommendation of ODS to patients (P<0.001) were significantly associated with personal ODS use during the pandemic. Vitamin C was the most commonly used (81.3%) and recommended (95.0%) ODS. “To maintain overall health and wellness” was the most common reason for personal ODS use and recommendation to patients (83.3% & 79.2%). Given the increasing rate of ODS use during the pandemic, further research should be done so that evidence-based recommendations can be formulated to ensure patient safety.
Reversion Porisms in Conics
Authors: Halbeısen Lorenz , Hungerbühler Norbert , Schiltknecht Marco
Published: October 2021

We give a projective proof of the butterfly porism for cyclic quadrilaterals and present a general reversion porism for polygons with an arbitrary number of vertices on a conic. We also investigate projective properties of the porisms.
PROBLEMS OF APPLICATION OF DECISION-MAKING MODELS IN THE REGIONAL ECONOMY UNDER CONDITIONS OF PARTIALLY RELIABLE INFORMATION
Authors: Vidadi Akhundov Vidadi Akhundov
Published: October 2021

In this study, attention is drawn to the under-explored area of strategic content analysis and the development of strategic vision for managers, with the supporting role of interpreting visualized big data to apply appropriate knowledge management strategies in regional companies. The study suggests improved models that can be used to process data and apply solutions to Big Data. The paper proposes a model of business processes in the region in the context of information clusters, which become the object of analysis in the conditions of active accumulation of big data about the external and internal environment.
Research has shown that traditional econometric and data collection techniques cannot be directly applied to Big Data analysis due to computational volatility or computational complexity. The paper provides a brief description of the essence of the methods of associative and causal data analysis and the problems that complicate its application in Big Data. The scheme of accelerated search for a set of causal relationships is described. The use of semantically structured models, cause-effect models and the K-clustering method for decision making in big data is practical and ensures the adequacy of the results. The article explains the stages of applying these models in practice.
In the course of the study, content analysis was carried out using the main methods of processing structured data on the example of the countries of the world using synthetic indicators showing the trends of Industry 4.0. When assessing Industry 4.0 technologies by region, the diversity of country grouping attributes should be considered. Therefore, during the analysis, the countries of the world were compared in two groups. The first group - the results for developed countries are presented in tabular form. For the second group, the results are presented in an explanatory form. In the process of assessing industrial 4.0 technologies, statistical indicators were used: "The share of medium and high-tech activities", "Competitiveness indicators", "Results in the field of knowledge and technology", "The share of medium and high-tech production in the total value added in the manufacturing industry", “Industrial Competitiveness Index (CIP score)”. As a result, the rating of the countries was determined based on the analysis of these indicators. .
The reasons for the difficulties of calculations when processing Big Data are given in the concluding part of the article.
Keywords: K - clustering method, causal links, data point, Euclidean distance
When Themes Come True: Why Board Games are like Theme Parks
Authors: Makai Péter Kristóf
Published: October 2021

We seek meaning in our lives; we want our actions to matter. Games of all sorts, however, are among those activities where the consequences of our actions only play out in the world of the game, allowing us to experiment with different strategies in order to overcome our opponents without fear of causing a catastrophic mishap. While exchanging a couple of pieces of cardboard for wooden blocks to push a player token five centimetres to the right might spell victory at the final scoring of a complex board game, this is also frivolous in some fundamental way. Even so, tabletop games endow such trivial actions with meanings that make a marathon gaming session memorable – and they do it through theming.
ЮВІЛЕЙНА КОНФЕРЕНЦІЯ ІНСТИТУТУ ПРОФЕСІЙНО-ТЕХНІЧНОЇ ОСВІТИ НАПН УКРАЇНИ, ПРИСВЯЧЕНА 30-Й РІЧНИЦІ НЕЗАЛЕЖНОСТІ УКРАЇНИ
Authors: Bazyl Liudmyla
Published: October 2021

У статті представлено досягнення Інституту професійно-технічної освіти Національної академії педагогічних наук України. Наведено перспективні напрями реалізації провідних завдань Інституту щодо наукового і методичного супроводу інноваційного розвитку системи професійної (професійно-технічної) та фахової передвищої освіти. Схарактеризовано здобутки вчених Інституту професійно-технічної освіти НАПН України у суверенній державі, взаємодію наукової установи з закладами професійної (професійно-технічної) та фахової передвищої освіти, організаціями-партнерами, стейкхолдерами. Показано конструктивну взаємодію Інституту з навчально-методичними центрами професійно-технічної освіти у Вінницькій, Волинській, Дніпропетровській, Донецькій, Закарпатській, Кіровоградській, Київській, Луганській, Львівській, Миколаївській, Одеській, Сумській, Харківській, Черкаській областях, що здійснюється 15 років згідно з укладеними угодами. Звернуто увагу на ключові завдання, які постають перед сучасною системою професійної (професійно-технічної) та фахової передвищої освіти, та її пріоритети, що зумовлені утвердженням незалежності нашої країни.
ІНСТИТУАЛІЗАЦІЯ ТА ІНКЛЮЗІЯ — ДВА КРИЛА ОСВІТИ ДІТЕЙ З ОСОБЛИВИМИ ОСВІТНІМИ ПОТРЕБАМИ
Authors: Lugovyi Volodymyr
Published: October 2021

У виступі зазначено динамізм у реформуванні сфери освіти дітей із особливими освітніми потребами останніми роками на засадах дитиноцентризму. Наголошено на важливій ролі в модернізації цієї освітньої ланки щорічних міжнародних конгресів зі спеціальної педагогіки і психології, що проводяться Національною академією педагогічних наук України у співпраці із закладами вищої освіти України і зарубіжжя. Аргументовано, що тенденція прискореного розвитку інклюзивного навчання забезпечує баланс інституційної та інклюзивної форм освіти згаданої категорії дітей. Подальше вдосконалення освіти дітей з особливими освітніми потребами вимагає модернізації технологій та інструментів діагностики розвитку дитини, осучаснення змісту і методів навчання.
COVID-19 sirgusių ligonių hospitalizavimo elektrokardiogramų apžvalga
Authors: Globytė Emilija , Samoškaitė Gabrielė , Kalinauskienė Eglė , Naudžiūnas Albinas , Jucevičius Jonas
Published: October 2021

Įvadas. COVID-19 yra greitai plintanti kvėpavimo sistemos infekcinė liga, kurią sukelia virusas, vadinamas ūminiu kvėpavimo sindromu koronavirusu-2 (SARS-CoV-2). Ši infekcija naudoja angiotenziną konvertuojamųjų fermentų 2 (AKF 2) receptorius ir paprastai plinta per kvėpavimo takus. SARS-CoV-2 pažeidžia ir kitus organus, kurie ekspresuoja AKF 2 receptorius. Patekę į organizmą virusai veikia imuninį atsaką. Padidėjęs imuninis atsakas dažnai sukelia citokinų antplūdžius, kurie gali sąlygoti mirtį nuo COVID-19. Sergantiesiems šia liga pastebėti pokyčiai ir elektrokardiogramose. Dažniausi iš jų yra: sinusinė tachikardija, PV, PP, skilvelių aritmijos, rečiau: bradikardijos, ašies nuokrypis, ST segmento ir T bangos pokyčiai. Tikslas. Apžvelgti LSMU Kauno ligoninėje hospitalizuotų pacientų, sirgusių COVID-19 infekcija, demografinius, klinikinius duomenis bei EKG pokyčius hospitalizavimo metu. Metodai. tyrimui naudotos 30 pacientų, hospitalizuotų LSMU Kauno ligoninėje dėl COVID-19, atliktos EKG. Rezultatai analizuoti naudojant „IBM SPSS statistics 20“ duomenų analizės paketą, pritaikytą „Windows“ operacinei sistemai ir analizuoti EKG pokyčiai sergantiesiems COVID-19. Rezultatai. 33,33 proc. pacientų – prailgėjęs QRS, 30,00 proc. pacientų stebėta levograma, 10,00 proc. – dekstrograma, 23,33 proc. pacientų EKG stebima ST segmento elevacija, 16,66 proc. – T inversija, 10,00 proc. – ST segmento depresija, 10,00 proc. PV, 13,33 proc. pacientų kairės Hiso pluošto kojytės blokada, o mažiausiai pacientų sudarė turintys dešinės Hiso pluošto kojytės blokadą – 3,33 proc. Išvados. Atliktų tyrimų analizių ir LSMU Kauno ligoninės tyrimo išvados: 1. Sergantiesiems COVID-19 liga, hospitalizavimo metu atliktose elektrokardiogramose dažniausiai stebimi šie pokyčiai: prailgėjęs QRS, ašies nuokrypis į kairę, ST segmento elevacija, T dantelio inversija, ST segmento depresija, kairės Hiso pluošto kojytės blokada, PV, dekstrograma ir mažiausiai pacientų sudarė turintys dešinės Hiso pluošto kojytės blokadą. 2. Norint įvertinti ilgalaikius širdies ir kraujagyslių sistemos pokyčius po persirgto COVID-19 reikalingi tolesni pacientų tyrimai.
Autoimuninių pūslinių ligų paplitimas ir priežastys
Authors: Bolevičienė Živilė , Aharon Aviv , Kučinskienė Vesta
Published: October 2021

Autoimuninės pūslinės ligos yra retų heterogeninių odos ligų grupė, kurioms būdingas intraepiderminių arba subepiderminių pūslių susiformavimas. Informacija apie šių ligų paplitimą yra ribota ir įvairiuose pasaulio regionuose skiriasi. Autoimuninių pūslinių ligų priežastys susijusios su genetiniu polinkiu bei ligą skatinamaisiais endogeniniais ir egzogeniniais veiksniais.
Šarlio Bone sindromas: literatūros apžvalga
Authors: Skardžiūtė Silvija
Published: October 2021

Šarlio Bone sindromas yra būklė, kurios metu regos sutrikimus turintiems pacientams pasireiškia regos haliucinacijos. Simptomai gali atsirasti sumažėjus regos aštrumui, sergant akių ligomis, tokiomis kaip, amžinė geltonosios dėmės degeneracija, katarakta ir diabetinė retinopatija. Pacientai suvokia, kad haliucinacijos nėra tikros, neturi kitų jutimų sutrikimo ir kognityvinės funkcijos pažeidimo. Dėl patiriamų paprastų arba kompleksinių regos haliucinacijų asmenys dažnai jaučia nerimą ir izoliaciją. Kai kuriais atvejais būklė gali tęstis kelerius metus ir turėti neigiamą įtaką žmogaus gyvenimo kokybei. Šarlio Bone sindromas dažnai yra klaidingai diagnozuojamas arba nediagnozuojamas dėl šią būklę supančios stigmos ir medicinos personalo žinių stygiaus. Siekiant, kad pacientams būtų suteikta visa reikalinga informacija apie patiriamas regos haliucinacijas, svarbu išnagrinėti šios būklės etiologinius, patogenetinius veiksnius, tinkamas diagnostikos ir gydymo galimybes.
Komunikacijos apie COVID-19 vakciną skaidrumo svarba
Authors: Čaplinskas Saulius
Published: October 2021

COVID-19 vakcinos yra „gyvybiškai svarbi priemonė“, padedanti kovoti su dabartine pandemija [1], todėl, kuriant ir platinant vakcinas, buvo investuota precedento neturinti išteklių suma, pabrėžė Pasaulio sveikatos organizacija (PSO). Sparčiai sukurta veiksminga ir saugi vakcina neturės jokio poveikio, jei pasaulio piliečiai nenorės skiepytis. Atsiradus labiau užkrečiamiems ir potencialiai vakcinoms atspariems koronaviruso variantams, norint pasiekti kolektyvinį imunitetą, ne tik turės pasiskiepyti didelė gyventojų dalis [2], bet gali tekti skiepytis ir pakartotinai. Didelę visuomenės dvejonę dėl vakcinų rodo ne tik daugelis tarptautinių tyrimų [3–6], bet ir ypatingą vakcinos šalininkų ir dvejojančių vakcinacija žmonių susipriešinimo lygį pasiekusi situacija Lietuvoje bei kitose pasaulio šalyse. Pagrindinis uždavinys yra ne tik užtikrinti pakankamą vakcinų prieinamumą, bet ir jų priimtinumą tiek dabar, tiek ateityje. Tam Lietuvoje nebuvo skiriama tinkamo dėmesio, nes visa komunikacija buvo nukreipta į informavimą apie vakcinų prieinamumą ir tiesiog raginimą (ar net tam tikrą spaudimą) skiepytis.
TECLA. Revista de la Consejería de Educación en el Reino Unido e Irlanda
Authors: Porteiro Fresco Minia
Published: October 2021

TECLA. Revista de la Consejería de Educación en el Reino Unido e Irlanda. 1/2020. Edición: mayo 2020. NIPO: 847-19-076-3. https://sede.educacion.gob.es/publiventa/tecla-n-12020-revista-de-la-consejeria-de-educacion-en-el-reino-unido-e-irlanda/ensenanza-lengua-espanola/24016 (Reseña de Minia Porteiro Fresco).
Xi Jinping - A ascenção do novo timoneiro da China: o homem, a política, o mundo
Authors: Tavares da Silva Jorge
Published: October 2021

O presidente chinês Xi Jinping é hoje uma das figuras mais emblemáticas e poderosas na paisagem política internacional. O Novo Timoneiro da China, nas subtilezas da sua ascensão, dá-nos uma ilustração das vicissitudes de um sistema político que deambula entre a crença da meritocracia e a realidade do guanxi. Herdeiro de uma genética vermelha, tem no seu pai o pilar de sustentação, que, embora o tenha marcado pelas agruras da distopia, não lhe desviou o sentido de orientação. Chega ao topo, segura-se com afinco às amarras do poder, atira-se aos corruptos e alimenta os pobres. Acima de tudo, Xi Jinping exalta as virtudes da civilização através do slogan do Sonho da China, seleciona adágios e atira-se a todos os quadrantes geográficos. Assim, através de um modelo de governação assertivo, envolto na sua imagem, o sistema de Partido único transforma-se paulatinamente numa nação de um só homem. Com a análise contida neste livro, da dimensão individual à coletiva, do passado ao presente, percorrendo-se a anatomia do seu líder supremo e da sua cosmovisão, procura-se oferecer um melhor conhecimento do papel da China no mundo contemporâneo.
Proyectos para la conservación y valorización del yacimiento arqueológico de la Motilla del Azuer (Daimiel, Ciudad Real). Intervenciones 2013-2018
Authors: Torres Mas Miguel
Published: October 2021

El yacimiento arqueológico de la Motilla del Azuer, localizado en Daimiel (Ciudad Real,) constituye el mejor representante de una tipología de enclaves únicos dentro de la prehistoria como fueron las motillas. El desarrollo de trabajos arqueológicos en este asentamiento ha permitido descubrir un legado extraordinario que destaca por su interés científico, su riqueza monumental y por su representatividad para el conocimiento del pasado de este territorio. Por estas razones, el Ayuntamiento de Daimiel ha impulsado una línea estrategia en torno a la gestión de este bien, estimando acciones para su conservación y valorización. Asimismo, debido a las características de este recurso arqueológico ha sido necesario llevar a cabo planteamientos específicos y precisos para su ejecución. En este artículo presentamos los proyectos realizados entre los años 2013 y 2018 en torno a estos campos, obteniendo unos resultados beneficiosos para el enclave y la sociedad de su entorno.
Stable isotope study through the Permian-Triassic boundary in East Greenland
Authors: Clemmensen L.B. , Holser W. , Winter D.
Published: October 2021

A survey of stable isotope ratios in sediments spanning the Permian-Triassic boundary in East Greenland shows Upper Permian evaporites to have b34S = + 10.6 ± 1.6%o and limestones to have b13Cmb = +4.5 ± 0.4%o, in conformity with similar values from probable correlative formations in Europe and North America. Most values of both isotopes in Triassic formations are lower and scattered, apparently reflecting varying inputs of non-marine waters including the oxidative erosion of isotopically light sulfur. This transition in the East Greenland section has obscured any clear detection of chemical events recorded elsewhere: a drop in marine b13C.,.,b near the Penman-Triassic boundary, and a sharp rise in b34S,1t in latest Scythian time.
Diagenesis of Middle Jurassic Haldager Formation Sandstone in the Danish Subbasin, North Jutland
Authors: Nielsen B. L. , Friis H.
Published: October 2021

The Middle Jurassic Haldager Formation sandstones are mainly quartz arenites to subarkoses and sub­litharenites. The diagenetic evolution of these sandstones is dominated by early quartz and kaolinite ce­mentation which occur randomly distributed in the fluvio-deltaic sandstones whereas poikilotopic calcite cement is important in the marine deposits of the formation. Siderite, pyrite and Fe-hydroxides are minor, but common diagenetic minerals. The quartz and kaolinite precipitated from mildly acid formation water, which probably developed from the initial fresh water of the depositional environment. Where the sand­stones are not sufficiently cemented, compaction may be important with development of pressure solution and crushing of quartz grains at burial depths of about 2000 m. The porosity is generally good, but the presence of large amounts of authigenic kaolinite represents a potential risk of fines migration during pro­duction of fluids from the reservoir.
Recent advances in organocatalytic asymmetric aza-Michael reactions of amines and amides
Authors: Sharma Pratibha , Gupta Raakhi , Bansal Raj Kumar
Published: October 2021

Nitrogen-containing scaffolds are ubiquitous in nature and constitute an important class of building blocks in organic synthesis. The asymmetric aza-Michael reaction (aza-MR) alone or in tandem with other organic reaction(s) is an important synthetic tool to form new C–N bond(s) leading to developing new libraries of diverse types of bioactive nitrogen compounds. The synthesis and application of a variety of organocatalysts for accomplishing highly useful organic syntheses without causing environmental pollution in compliance with ‘Green Chemistry” has been a landmark development in the recent past. Application of many of these organocatalysts has been extended to asymmetric aza-MR during the last two decades. The present article overviews the literature published during the last 10 years concerning the asymmetric aza-MR of amines and amides catalysed by organocatalysts. Both types of the organocatalysts, i.e., those acting through non-covalent interactions and those working through covalent bond formation have been applied for the asymmetric aza-MR. Thus, the review includes the examples wherein cinchona alkaloids, squaramides, chiral amines, phase-transfer catalysts and chiral bifunctional thioureas have been used, which activate the substrates through hydrogen bond formation. Most of these reactions are accompanied by high yields and enantiomeric excesses. On the other hand, N-heterocyclic carbenes and chiral pyrrolidine derivatives acting through covalent bond formation such as the iminium ions with the substrates have also been included. Wherever possible, a comparison has been made between the efficacies of various organocatalysts in asymmetric aza-MR.
THE IMPACT OF COVID-19 PANDEMIC ON THE TOURISM SECTOR IN INDONESIA
Authors: Purba Jan Horas Veryady , Fathiah Ritha , Steven Steven
Published: October 2021

The tourism is one of the strategic sectors and has an important role as a source of foreign exchange and encourages national economic growth. Since March 2020, the Covid-19 pandemic has begun to enter Indonesia, and the cumulative infection curve has not sloped, and is still increasing exponentially until now. This phenomenon has resulted in a contraction in the Indonesian economy or created negative economic growth, as well as creating very bad conditions for the tourism sector in Indonesia. This study aims to examine the influence of the Covid-19 pandemic on tourism and its implications for economic growth in Indonesia. The data used are quarterly time series data before and after the Covid-19 Pandemic (2018-2020). This study uses a regression equation model that is estimated by using ordinary least square (OLS). Secondary data used are data air transport and hotel accommodation, as a proxy for tourism variables. The results show that the Covid-19 Pandemic has a negative effect on Indonesian tourism, and has negative implications for Indonesia's GDP. From the simulation results, the findings of this study also calculate the amount of potential lost in the Turism and Indonesian economy during the Covid-19 Pandemic.
VISITOR MANAGEMENT IN THE SITUGEDE ECO-TOURISM AREA
Authors: V SriHadi Cecilia , Roberto Roberto
Published: October 2021

SituGede is a valuable environmental asset for soil and water ecosystems in the city of Bogor and its surroundings. The productive use of this area can be done through ecotourism. The concept of back to nature, is a contemporary lifestyle that is increasingly popular, especially after the covid 19 pandemic. In order for the function of ecotourism to be carried out in a sustainable manner, collaboration between concepts and stakeholders is a priority. Visitor management is one way that can be taken in an effort to make SituGede a sustainable ecotourism destination
THE EFFECT OF CASH CONVERSION CYCLE ON THE PROFITABILITY OF THE RETAIL TRADE SECTOR COMPANIES
Authors: Mandalaputri Renata , Fettry Sylvia , Felisia Felisia
Published: October 2021

One of the company's goals is to increase company value. In order to achieve these goals the company must increase its profitability. To increase profitability, companies have to manage working capital effectively and efficiently. The effectiveness of working capital management can be measured using the Cash Conversion Cycle (CCC). CCC consists of Days Sales Outstanding (DSO), Days Sales Inventory (DSI), and Days Payable Outstanding (DPO). This study aims to determine the effect of the CCC and its components on company profitability. The type of data used in this study is secondary data which are collected from of corporate financial reports. The population in this study are retail trading companies listed on the Indonesia Stock Exchange during the 2015-2019 period. The data analysis method used in this study is the multiple linear regression method for panel data and simple linear regression for panel data. The results showed that partially, DSO, DSI, and CCC had a negative effect on company profitability. Meanwhile, the DPO has a positive effect on company profitability. Simultaneously, DSO, DSI, and DPO have an effect on profitability. Therefore, companies need to pay attention to the CCC and its components (DSO, DSI, and DPO) and manage it properly.
RETURN ON EQUITY, DEBT TO TOTAL ASSET RATIO, AND COMPANY VALUE
Authors: Yustrianthe Rahmawati Hanny , Mahmudah Sufyana
Published: October 2021

This study aimed to determine the effect of Return on Equity (ROE) and Debt to Total Asset Ratio (DAR) on Firm Value in manufacturing companies listed on the Indonesia’s Stock Exchange 2015-2019, both partially and simultaneously. The research was categorized as an associative research by using. 179 companies listed on the Indonesia Stock Exchange (BEI) as a population. The sample obtained from 63 companies were selected using purposive sampling technique. The data in this study are secondary data obtained through the Indonesia Stock Exchange (BEI) and related company websites then being analyzed with multicollinearity test, heteroscedasticity test, autocorrelation test, multiple linear regression test, and normality test. The results showed that the Return on Equity (ROE) has a positive effect on Firm Value, Debt to Total Asset Ratio (DAR) has no significant effect on firm value, and Return on Equity (ROE) & Debt to Total Asset Ratio (DAR) has affect on firm value.

 

Keywords: ROE, DAR, Book Value.
BUSINESS RISK ANALYSIS IN ARI WIBOWO'S CENTRAL TILE INDUSTRY IN LOHJINAWI VILLAGE, PRINGSEWU REGENCY IN 2018 - 2020
Authors: Wagiyu Wagiyu , Setiawan Heri
Published: October 2021

Business risk is the potential deviation of corporate results  and financial results because the company enters a certain business with a typical industrial environment and uses certain technologies. In business there are so many decisions or actions that must be made, it makes more and more risks that may occur as a result. The purpose of this research is to find out how big the Business Risk Central Tile Industry in Lohjinawi Village, Pringsewu Regency,The analysis was carried out descriptively, using standard deviation of ROE; Financial Leverage; Operating Leverage namely the sensitivity of EBIT to changes in the company's sales; as well as Degree of Operation Leverage (DOL). The results of the analysis show that: 1) ROE, has increased due to an increase in Sales and an increase in EAT, and vice versa; 2)The use of debt can increase the Company's ROE; 3) Operating Leverage, where EBIT is very sensitive to changes in company sales; 4)Degree of Operating Leverage (DOL) measures what percentage of EBIT changes if sales; 2018-2019 of 1.50x  which means DOL of 150% that every 100% increase or 1x sales will cause an increase in operating profit of 1.50x otherwise, if sales decrease 1x then operating profit will decrease by 1.50x. While the year 2019-2020 amounted to 2.01x which means a DOL of 201% indicates that every 100% or 1x decrease in sales will cause a 2.01x decrease in operating profit. On the other hand, if sales decrease 1x, operating profit will decrease by 2.01x.
Thermodynamic and kinetic models for the removal of copper and cadmium using industrial effluents by mixed adsorbent
Authors: Murthy K S R , Tadepalli Srinivas
Published: October 2021

The potential of Activated Charcoal and bone Charcoal as a low cost material for the removal of copper and cadmium from synthetic metal solution was studied. A number of experiments were performed in order to determine the potential capacity of the adsorbent in terms of thermo Dynamic equilibrium from the batch data. The Positive values of change in Enthalpy show that the process is endothermic in nature for Cd (II) and the negative values of Change in Enthalpy shows that the process is exothermic in nature for Cu (II). The standard Gibb’s free energy values are positive which means that the process is not spontaneous in nature. The negative values of ΔS show that there is decrease in randomness at the solid/solution interface during the adsorption of copper. The study revealed that mixed adsorbent prepared by blending the activated charcoal and bone charcoal in 1: 1 ratio has more potential to act as an adsorbent for the removal of Cu and Cd from aqueous solution. The optimum temperature was found to be 40°C for both the metals. The higher correlation coefficient R2(0.9824) value shown that cadmium ions were well fitted the thermodynamic model comparing copper ions. The batch adsorption studies have been carried out for 2 hrs considering all the 6 parameters by optimizing each of them. The data obtained for optimized parameters were studied through fitting of kinetic models such as Pseudo-first order and Pseudo second order models for both Copper and Cadmium along with Correlation or regression coefficient (R2) values.
Mioma parauretral en mujer posmenopausica con miomatosis uterina: reporte de caso
Authors: Aguilar Valeriano Hadwin , Meza Torres Kerima
Published: October 2021

Los miomas parauretrales representan un tipo de tumor del tracto genitourinario infrecuente en mujeres. Muy pocos casos han sido reportados en la literatura hasta el momento, sin encontrar publicaciones al respecto en nuestro país.

En esta ocasión se reporta un caso de una mujer femenina de 56 años que se presenta con historia de una tumoración a nivel parauretral. Confirmando el diagnostico a traves de estudio histopatológico, con tratamiento quirúrgico y mejoría total del cuadro clínico.
Pancreatitis por hipertrigliceridemia en el embarazo
Authors: Murgas Angely , Sanjur Roxarys , Reyes Osvaldo
Published: October 2021

La pancreatitis aguda es una causa rara de dolor abdominal durante el embarazo, puede ser potencialmente mortal para la madre y el feto. Se presenta con mayor frecuencia durante el tercer trimestre debido a un aumento progresivo de los triglicéridos y el colesterol como cambios fisiológicos del embarazo. Sin embargo, estos niveles no logran sobrepasar los 300 mg/dL; pacientes con niveles de triglicéridos por encima de 1000 mg/dL están en riesgo incrementado de desarrollar pancreatitis severa. Los criterios diagnósticos y protocolos de manejo no son específicos para esta patología durante el embarazo. El Tratamiento con aféresis puede ser usado como manejo primario durante el embarazo logrando una disminución rápida y segura de los niveles plasmáticos de triglicéridos.
Presentación de cara
Authors: Reyes Osvaldo
Published: October 2021

Paciente de 25 años, G1P0 con gestación de 38 semanas. Acude en labor de parto con dilatación completa y presentación de cara.

Se pasa a expulsivo y se atiende parto vaginal de producto en presentación cefálica de cara, variedad mento anterior. Nace producto masculino, apgar 9/9, peso 3200g. Evolución neonatal satisfactoria.
Normal Doğum ve Sezaryende Doğum Sonu Stresin Emzirme Öz-yeterliliğine Etkisi
Authors: KAYA ŞENOL Derya , PEKYİĞİT Aylin
Published: October 2021

Amaç: Bu çalışmanın amacı doğum sonu dönemde annelerin yaşadığı stresin emzirme öz-yeterliliğe etkisini belirlemektir.

Gereç ve Yöntem: Araştırma analitik ve kesitsel tiptedir. Araştırmanın verileri bir devlet hastanesinin çocuk polikliniklerinde anket formu kullanılarak toplanmıştır. Çalışma 148 anne ile tamamlanmıştır. Verilerin analizinde tanımlayıcı istatistiksel metodları, Student t Test, Pearson Ki-Kare testi ve Korelasyon t testi kullanılmıştır.

Bulgular: Katılımcıların Doğum Sonu Stres Ölçeği puan ortalamaları 21-34 yaş aralığında, üniversite mezunu olan, çalışıp şuan ücretsiz izinde olan, gelir düzeyi iyi olan, çekirdek ailede yaşayan, eşi üniversite mezunu olan ve eşi çalışmayan kadınlarda daha yüksektir. Emzirme Öz-yeterlilik Ölçeği puan ortalamalarına bakıldığında ise, primigravidalarda, abortusu olanlarda ve 3 ve üzeri yaşayan çocuğu olan, gebeliği planlı olmayan, normal doğum yapan ve bebeği 36 hafta ve altında doğan kadınların puanları daha yüksek saptandı (p
La ville et la vieillesse : espace public, temporalité, mobilité
Authors: Clément Serge
Published: October 2021

Ce bref tour d'horizon de la sociologie urbaine tente de faire émerger quelques cadres de réflexion et de questionnement sur la place du vieillissement dans la ville. Trois grandes dimensions de la vie sociale sont considérées : celle des rapports entre espace privé et espace public, celle de la temporalité et des rythmes de la vie quotidienne, celle de la mobilité et en particulier de l'accessibilité. Il reste à la recherche d'aujourd'hui à dégager les diverses possibilités d'expression du vieillissement : les espaces urbains sont-ils des variables pertinentes pouvant rendre compte de cette diversité ?
Evaluation of microwave-dried black soldier fly (Hermetia illucens) larvae meal as a dietary protein source in broiler chicken diets
Authors: Kim B. , Kim H.R. , Baek Y.-C. , Ryu C.H. , Ji S.Y. , Jeong J.Y. , Kim M. , Jung H. , Park S.H.
Published: October 2021

Here, the effect of microwave-dried black soldier fly (Hermetia illucens) larvae meal (HILM) as a dietary protein source on the growth performance and health of broilers was evaluated. A total of 126 male broilers were randomly allocated to three treatments (six replicates of seven birds per group): control diet (CON) of corn and soybean meal and two experimental diets in which soybean meal was replaced with 25% (25HILM) or 50% (50HILM) HILM. The broilers were slaughtered at 35 d to determine the apparent ileal digestibility (AID), volatile fatty acid (VFA) profiles, and length and weight of the small intestine. Blood samples were collected from 36 randomly selected birds (12 broilers per treatment) to determine serum parameters and haematological traits. Average daily gain, feed intake, and AID of protein were decreased (P<0.05) in the 50HILM group compared with those in the CON group. Dietary HILM increased (P<0.05) the relative length of the entire digestive tract and total VFAs in the caecal digesta. Serum low-density lipoprotein cholesterol was the lowest (P<0.01), but the triglyceride levels were the highest (P<0.05) in the 50HILM group. The serum phosphorus level was lower in both HILM diet-fed groups (P<0.01), whereas the creatine phosphokinase level was lower in the 50HILM group than in the CON group. In contrast, the 50HILM group showed higher (P<0.05) monocyte and red blood cell distribution width-standard deviation. In conclusion, dietary microwave-dried HILM positively influenced the VFA and cholesterol levels; however, growth performance was negatively affected by malnutrition caused by low protein digestibility in the 50HILM group. Microwave-dried HILM is a valuable ingredient for broiler diets, with up to 25% substitution showing no detrimental effects on growth performance and health. Further studies are needed to improve HILM digestibility.
7-Year Results of SMILE for High Myopia: Visual and Refractive Outcomes and Aberrations
Authors: Damgaard Iben Bach , Sejersen Henrik , Ivarsen Anders , Hjortdal Jesper
Published: October 2021

PURPOSE:

To evaluate the 7-year visual, refractive, and optical outcomes following small incision lenticule extraction (SMILE) for high myopia and myopic astigmatism.

METHODS:

Sixty-nine eyes (69 patients) undergoing SMILE between March 2011 and January 2012 at Aarhus University Hospital were included. Preoperative, 3-month, 3-year, and 7-year evaluation included: manifest refraction and uncorrected (UDVA) and corrected (CDVA) distance visual acuities, total corneal refractive power (TCRP), average keratometry (Km), aberrations, and central corneal thickness (CCT).

RESULTS:

Preoperative spherical equivalent averaged −7.53 ± 1.18 diopters (D). Twenty-seven eyes were targeted emmetropia. In the emmetropic eyes, the postoperative logMAR UDVA remained stable (
P
= .11). When including all eyes, UDVA became worse from 3 to 7 years (3 months: 0.050 ± 0.16 logMAR; 3 years: 0.044 ± 0.21 logMAR; 7 years: 0.131 ± 0.29 logMAR;
P
< .027), whereas CDVA remained stable (3 months: −0.07 ± 0.09 logMAR; 3 years: −0.09 ± 0.08 logMAR; 7 years: −0.09 ± 0.08 logMAR,
P
> .99). At 7 years, 59.4% and 81.2% were within ±0.50 and ±1.00 D of target refraction, respectively. Average refractive regression was significant from 3 months to 7 years (−0.34 ± 0.69 D) and from 3 to 7 years (−0.25 ± 0.41 D,
P
< .05). After exclusion of three outliers with high myopic correction (< 9.63 D) and considerable regression (<−1.50 D), the average regression over 7 years was −0.25 ± 0.49 D (
P
= .004) with no significant change from 3 to 7 years (
P
= .069). Average CCT, TCRP, and anterior Km significantly increased (
P
< .001), whereas the posterior Km and total corneal aberrations remained stable (
P
> .092).

CONCLUSIONS:

The long-term visual outcome remained stable after SMILE, but with an average regression of −0.34 D over 7 years. A minor group with high myopic correction exhibited considerable refractive regression years after SMILE.

[
J Refract Surg
. 2021;37(10):654–661.]
Corneal Stability and Visual Acuity 1 Year After Corneal Cross-linking Assessed Using the ABCD Keratoconus Staging System
Authors: Danesh Zeynab , Sedaghat Mohammad-Reza , Momeni-Moghaddam Hamed , Yekta Abbas-Ali , Belin Michael W.
Published: October 2021

PURPOSE:

To assess corneal stability and corrected distance visual acuity (CDVA) 3, 6, and 12 months following corneal cross-linking (CXL) using the ABCD keratoconus staging system.

METHODS:

This prospective longitudinal study included 31 eyes with keratoconus receiving CXL based on the standard Dresden protocol. CDVA, refraction, and Scheimpflug tomography with the Pentacam HR (Oculus Optikgeräte GmbH) were evaluated before and after surgery. Geometric and functional changes were assessed using the actual values and staging of each element of the ABCD keratoconus staging system. A, B, C, and D refer to the anterior and posterior radii of curvature in a 3-mm zone centered on the cor-neal thinnest point, minimum corneal thickness, and CDVA, respectively.

RESULTS:

There were no significant changes in the actual values of anterior radius of curvature (
P
= .497) and CDVA (
P
= .082), whereas posterior radius of curvature (
P
= .007) and corneal thinnest point (
P
< .001) showed significant changes statistically. Pairwise comparison showed only a statistically significant steepening in posterior radius of curvature at 3 months after CXL compared to the preoperative radius (
P
= .002) and a significant decrease in corneal thinnest point at 3 (
P
< .001) and 6 (
P
= .028) months after CXL compared to baseline assessment. Staging of each element of the ABCD keratoconus staging system indicated no change between baseline and 3, 6, and 12 months after CXL.

CONCLUSIONS:

The geometric and functional parameters included in the ABCD keratoconus staging system showed stability of corneal status and CDVA 1 year after CXL.

[
J Refract Surg
. 2021;37(10):700–706.]
Barriers to Follow-Up Retinal Care During the COVID-19 Pandemic: A Survey Study
Authors: Shields Charlotte N. , Cherkas Elliot G. , Mokhashi Nikita , Cai Louis Z. , Pandit Ravi R. , Patel Samir N. , Hsu Jason , Kuriyan Ajay E. , Klufas Michael A. , Ho Allen C.
Published: October 2021

BACKGROUND AND OBJECTIVE:

To characterize patient-identified barriers to care in those non-compliant with retina appointments during the coronavirus disease 2019 (COVID-19) pandemic.

PATIENTS AND METHODS:

Inclusion criteria included non-compliant patients from March 1, 2020 to May 1, 2020. Ultimately, 1,345 patients were invited to complete a 14-question survey. A retrospective chart review correlated clinical and demographic information. Univariate logistic regression, independent-samples
t
-test, and Pearson correlation coefficient identified differences among subgroups.

RESULTS:

Of the 1,345 patients, 181 (13.5%) completed the survey. The most significant barriers to care included fear of COVID (76/181; 42.0%), wait times (21/181; 11.6%), and costs (11/181; 6.1%). Patients who got their COVID information from the Centers for Disease Control and Prevention (7.8 ± 2.4) and televised news (8.0 ± 2.0) had higher levels of fear. Finally, patients with diabetic retinopathy and higher Charlson Comorbidity Index scores had greater concerns of COVID (
P
= .034 and
P
= .047, respectively).

CONCLUSION:

This survey study suggests fear of COVID-19 is a prominent new barrier to retinal care. Identifying those at risk for loss to follow-up can guide practices as the pandemic continues.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:526–533.]
Predicting Post-Cataract Surgery Visual Acuity in Vitrectomized Eyes: The Efficacy and Accuracy of “Lambda” Retinometry
Authors: Mimouni Michael , Israeli Asaf , Shapira Yinon , Socea Sergiu D. , Blumenthal Eytan Z. , Zayit-Soudry Shiri
Published: October 2021

BACKGROUND AND OBJECTIVE:

Determine the ability of Lambda retinometry to predict post-cataract surgery visual acuity in vitrectomized eyes.

PATIENTS AND METHODS:

Prospective study including 47 cataract surgery candidates with a history of pars plana vitrectomy (PPV). Lambda retinometry using a hand-held Lambda retinometer and best-corrected visual acuity (BCVA) were measured preoperatively, and BCVA was reassessed postoperatively.

RESULTS:

Lambda predictions strongly correlated with postoperative BCVA (logarithm of the minimum angle of resolution [logMAR]) (
P
< .001,
r
2
= 0.57), especially combined with preoperative BCVA (logMAR) (
P
< .001,
r
2
= 0.65). In 89% of cases, postoperative BCVA was equal to or higher than the prediction. Neither cataract grades nor indications for PPV were associated with the accuracy of Lambda predictions (
P
= .882 and
P
= .790, respectively). Underestimation of visual outcome was more common than overestimation. A Lambda prediction of ≥ 20/40 (Snellen) had a positive predictive value of 85.7% and a negative predictive value of 73.6% for the postoperative outcome.

CONCLUSIONS:

Lambda retinometry can reliably predict the postoperative BCVA in cataract patients who previously underwent PPV, with a tendency towards underestimation.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:535–542.]
A Modified Surgical Technique for Submacular Injection
Authors: Ohayon Avi , Schwartz Shulamit , Loewenstein Anat , Seknazi Daniel , Souied Eric H. , Barak Adiel
Published: October 2021

BACKGROUND AND OBJECTIVE:

To describe a modified simple surgical technique for submacular injection.

PATIENTS AND METHODS:

The technique involves pars plana vitrectomy, a viscous fluid control (VFC) system for semi-automatic subretinal injection of tissue plasminogen activator (tPA), bevacizumab, and air and intravitreal gas injection for submacular hemorrhage (SMH), or subretinal balanced salt solution (BSS) for submacular perfluorocarbon (PFC) bubbles or persistent macular holes.

RESULTS:

This technique was successfully performed for SMH (five patients), a subfoveal PFC bubble (two patients), and persistent full-thickness macular hole (FTMH) (one patient). The single surgical complication was an FTMH in a PFC bubble. Four SMH patients had postoperative displacement of the hemorrhage. The FTMH was partially closed.

CONCLUSIONS:

Semi-automatic subretinal injection of tPA, bevacizumab, and air with the VFC system promoted displacement and clearance of SMH without complications. A subretinal BSS injection is effective for removing subfoveal PFC bubbles and for closing persistent FTMH.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:551–555.]
Geospatial Distribution of Ophthalmologists Older than Age 60 Years Relative to the Prevalence of COVID-19
Authors: Rasendran Chandruganesh , Haueisen Alexander J. , Wadhwa Raoul , Singh Rishi P.
Published: October 2021

BACKGROUND AND OBJECTIVE:

To evaluate coronavirus disease 2019 (COVID-19) cases as of February 1, 2021 and the proportion of ophthalmologists in the United States older than age 60 years to provide a framework for successful vaccine distribution for the ophthalmology workforce.

PATIENTS AND METHODS:

The Association of American Medical Colleges ophthalmologist workforce dataset (from 2019) for each state was combined with John Hopkins University's COVID-19 tracking data to determine exposure risk for ophthalmologists, especially those older than age 60 years.

RESULTS:

Of the 18,915 practicing ophthalmologists in the US, 37.6% are older than age 60 years. North Dakota (48.4%), Connecticut (46.8%), and Maine (46.7%) have the highest percentages. South Dakota (9,567), Utah (7,559), and Idaho (7,411) currently have the highest COVID-19 exposure burden per ophthalmologist older than age 60 years as of February 1, 2021.

CONCLUSION:

Care must be taken to distribute the COVID-19 vaccine in a safe and proactive manner to ophthalmologists that face high exposure risk, both to ensure physician safety and ensure adequate care for the population they serve.

[
Ophthalmic Surg Lasers Imaging Retina
. 2021;52:556–559.]
New Formulation of TiO2- ZnO Slurry for Facial Foundation Sunscreen Cream Application
Authors: Pijarn Nuchanaporn , Jankasemsook Wisallaya , Suwantha Supanida , Intaraprasert Janpen
Published: October 2021

The objective of this research was to prepare ready-to-use TiO2 and ZnO in slurry form for ready-to-use in facial foundation sunscreen. Two types of TiO2 sources were prepared as TiO2 slurry namely commercial TiO2 powder and synthesized TiO2 powder. Preparation of formula 1, 35 g solution PEG-10 dimethicone, and added 20 g solution cyclomethicone after that 45 g TiO2 powder was added slowly to the prepared substance, stirring and heated to 60-70 °C, and stir until the substance mix well. Formula 2, 46 g solution cyclomethicone added 2.5 g stearic acid and 2 g aluminum hydroxide after that stirring and heated to 60-70 °C until the substance mixed well, and TiO2 powder 49.5 g was added slowly to the continuous stirred and heated. On the other hand, ZnO slurry was prepared in the same steps. The results show that formula 1was the best formulation. Due to it was not precipitation and good compatibility with an emulsifier, therefore, formula 1was chosen to study in various volumes. The texture and stability of the prepared slurry were similar to the commercial slurry. Two sunscreen formulas were differently formulated by containing prepared and commercial slurry and evaluated. There were no significant differences in results between prepared slurry and commercial slurry. To investigate the satisfaction of products, 30 volunteers were asked to use products for one week and answer the questionnaires. The product containing prepared slurry was satisfied by 93.33% of volunteers, whereas the product containing commercial slurry was satisfied by 76.66% of volunteers.
Factors Influencing Dephosphorization of Low Carbon Steel in Converter
Authors: Liu Zhao , Cheng Shu Sen , Wang Liang
Published: October 2021

A 300-metric ton converter in a steel plant in China was studied. The influence of factors such as slag composition and temperature in the smelting process on the dephosphorization effect was statistically analyzed. The dephosphorization ability of slag increased firstly and then decreased with the increase of temperature, basicity and FeO content. Low-temperature, high-basicity and high-oxidizing slag are thermodynamically beneficial to promote the dephosphorization reaction, but the basicity is higher than 4.0, and the temperature is higher than 1640 °C are not conducive to the slag to obtain better fluidity. At the same time, too high FeO content will increase the activity coefficient of P2O5, thereby increasing its activity, which is not conducive to the progress of the dephosphorization reaction. As the end point content of carbon decreases, the oxygen content increases and the phosphorus content decreases. A very low carbon content is not conducive to metal yield and temperature control.