bluuebunny/crossref_metadata_2025 huggingface dataset:
FAKTOR-FAKTOR YANG BERHUBUNGAN DENGAN KELENGKAPAN PENGISIAN RESUME MEDIS PADA TINDAKAN SECTIO CAESAREA DI RS. dr. DRAJAT PRAWIRANEGARA KOTA SERANG
Authors: Ita Latho  , Nuria Fitri Adista  , Ika Apriyanti
Published: November 2022

Rumah sakit adalah sebuah instalasi yang meyelenggarakan pelayanan kesehatan secara profesional. Dalam menjalankan fungsinya rumah sakit harus mampu menyediakan pelayanan yang berkualitas dan bermutu terhadap pasien. Rumah sakit wajib menyelenggarakan kegiatan rekam medis sesuai dengan undang-undang nomor 44 tahun 2009 tentang rumah sakit. Permenkes 269/Menkes/Per/III/2008, merupakan landasan hukum penyelenggaraan rekam medis, semua tenaga medis dan para medis di rumah sakit yang terlibat penyelenggaraan rekam medis dapat melaksanakannya.

Dalam rangka meningkatkan mutu serta efisiensi pelayanan kesehatan di rumah sakit perlu adanya dukungan dari beberapa faktor yang terkait. Salah satunya faktor yang mendukung keberhasilan upaya tersebut adalah terlaksananya rekam medis yang sesuai dengan standar yang berlaku. Di dalam penyelenggaraan rumah sakit salah satu penunjang yang penting adalah terselenggaranya rekam medis secara baik dan benar. Penelitian ini bertujuan untuk mengetahui faktor-faktor yang berhubungan dengan kelengkapan pengisian resume medis pada tindakan Sectio Caesaria di RS. Dr. Drajat Prawiranegara Kota Serang. Rancangan penelitian yang digunakan pada penelitian ini adalah analitik kuantitatif dengan desain potong lintang (cross sectional). Populasi pada penelitian ini adalah semua petugas yang bekerja di Ruang Bersalin dan Unit Kerja Rekam Medis yang berjumlah 31 petugas.

Hasil penelitian Lebih dari setengahnya kelengkapan Resume Medis Tindakan Sectio Caesaria di RS.Drajat Prawiranegara Kota Serang  adalah lengkap sebesar (61,3%), lebih dari setengahnya pendidikan respoLebih dari setengahnya pemahaman responden adalah negative sebesar 56,6%, lebih dari setengahnya masa kerja petugas ≥ 2 tahun sebesar 67,7%, lebih dari setengahnya sarana prasarana lengkap sebesar 54,8%. Terdapat hubungan antara pendidikan dengan p value 0,002, antara masa kerja petugas p value 0,021, antara sarana prasarana dengan dengan kelengkapan pengisian resume medis pada tindakan Sectio Caesaria dengan p value 0,02.
Manajemen Perencanaan dan Pengelolaan Keuangan Rumah Tangga Untuk Meningkatkan Kesejahteraan Keluarga
Authors: Mustikowati Rita Indah , Kurniawan M. Yusuf , Ariyani Fitria
Published: November 2022

Keluarga berperan  penting dalam perekenomian suatu negara karena keluarga dapat berfungsi sebagai konsumen dan produsen. Rumah tangga sebagai konsumen dalam kegiatan sehari-hari mengeluarkan pengeluaran rutin untuk mencukupi kebutuhannya Dalam kehidupan rumah tangga peran Wanita sebagai  ibu rumah tangga memiliki peran yang sangat penting dalam mengelola keuangan rumah tangga dan memiiliki wawasan serta pengetahuan dalam  merencanakan dan mengelola keuangan. Perencanaan dan pengelolaan keuangan keluarga yang benar akan meningkatkan kesejahteraan keluarga. pelaksanaan rencana dan pengelolaan keuangan keluarga adalah sikap disiplin dalam melaksanakan apa yang telah direncanakan sehingga tidak akan terjadi banyak penyimpangan dari apa yang telah direncanakan. Hal  yang sangat penting guna membantu kehidupan keluarga dan masa depan anak serta masa pensiun.  Metode yang dikembangkan adalah penyuluhan, pelatihan dan pendampingan perencanaan  dan pengelolaan keuangan serta diberikan materi dan pelatihan sederhana tentang perencanaan dan pengelolaan keuangan keluarga dan solusi yang ditawarkan. Hasil dari pengabdian ini adalah Ibu-ibu menjadi memiliki pengetahuan tentang perencanaan dan pengelolaan keuangan rumah tangga, memiliki pengetahuan tentang penggunaan kebutuhan sesuai prioritas, memahami pola konsumsi sesuai  besar kecilnya tingkat pendapatan, memiliki pemahaman untuk merencanakan pengeluaran dan mengelola pendapatan
Hyperglycemic Crisis in Uncontrolled Diabetes Mellitus Type 2 Presenting as Breathlessness
Authors: Wardani Putu Intan Kusuma , Pretaliana Christina , Sugitto Henry Theo Prawira , Desmonta Eqen , Hersan Kevin , Shelly Vannesa , Hutapea Varda Natasya , Zahraisha Fadhilla Liefya , Mahardhika Jeffrey Christian , Nafthalena  , Rahardjo Theresia Monica
Published: November 2022

Background

Hyperglycemic crisis is emergency caused by metabolic problems due to uncontrolled diabetes mellitus. Hyperglycemic crisis consists of Hyperosmolar Hyperglycemic State (HHS) and Diabetic Ketoacidosis. Both are caused by relative or absolute deficiency of insulin; deficiency of insulin could be caused by type 1 and type 2 diabetes.

Case presentation

A 46-year-old woman came to the emergency room of Unggul Karsa Medika Hospital presenting with breathlessness which had occurred for a week. Her breathlessness was more severe on the day she presented to the emergency room. One week before, she went to a clinic nearby because of epigastric pain, but after returning home she felt breathless. After a few days, her breathlessness started to worsen, so she decided to go to emergency room. The patient had severe acidosis and high blood glucose. Hyperglycemia protocol of rehydration and insulin drip intravenously, accompanied by sodium bicarbonate and potassium chloride were given. Mechanical ventilation was used. The patient was healed and discharged safely after 9 days of hospitalization.

Conclusion

Hyperglycemic crisis is one of true emergency that can lead to mortality, thus prompt diagnosis and treatment should be done. It is important for clinicians to differ between HHS and DKA. HHS is caused by the relative or absolute deficiency of insulin while DKA is characterized by absolute insulin deficiency which prevents the body from metabolizing carbohydrates and results in severe hyperglycemia.  In DKA and HHS the main goal of therapy is to rehydrate, correct hyperglycemia, and to correct electrolyte imbalances.
Patient Satisfaction and Characteristics of Maternity Room from April to June 2022 at Unggul Karsa Medika Hospital
Authors: Rahardjo Theresia Monica , Kadam Yoctaf Octora , Mahardhika Jeffrey Christian
Published: November 2022

Background
Maternal Mortality Rate (MMR) is an indicator that reflects various aspects including the quality of healthcare from clinical standpoint, the quality of healthcare system, the quality of health insurance, the quality of referral systems and non-health aspects that related to healthcare such as economic, social, cultural, and education aspects. In order to reduce MMR, healthcare quality of maternity services should be increased. Patient satisfaction is one of indicators for healthcare quality. In this study, we aim to describe patient satisfaction in maternity room of Unggul Karsa Medika Hospital, Bandung, West Java, Indonesia.
Methods
This is a quantitative descriptive study conducted in Maternity Room, Unggul Karsa Medika Hospital, Bandung, West Java, Indonesia. The design of the study was cross-sectional. The research was conducted from April to June 2022. Minimal total sample of 97. Total sample that obtained in this study was 150 subjects. Sampling method used in this study was consecutive sampling.
Results
Percentage of total patient satisfaction of maternity room were slightly increasing from April to June 2022, with highest value was in June 2022 of 94,2%. Four out of six elements of patient satisfaction were increasing, which were speed of services, friendliness and responsiveness, clarity of information and instructions, and completeness of infrastructure and facilities.
Conclusion
Unggul Karsa Medika Hospital through its excellence service of maternity room has played a significant role to reduce maternal mortality rate in Indonesia, since good and increasing results in patient satisfaction of maternity room service from April to June 2022.
Precocious Puberty: A Case Report
Authors: Felita Anna , Sarahfebi Ivanna , Nadya Anastasia , Anjali Parbati , Daryanani Chandni P.
Published: November 2022

Background

Puberty is a transitional period in children with acceleration of growth and development of secondary sexual characteristics. When this period appears before the age of 8 to 9 years in children, it is called precocious puberty.  Depending on the primary source of the hormonal production, precocious puberty may be classified as central (gonadotropin dependent or true) or peripheral (gonadotropin independent or precocious pseudo-puberty).

Case presentation

We herein report a case of precocious puberty in a 7,5-year-old girl who has shown early sign of secondary sexual development. Patients complained pain on her nipple, her breasts began to grow in size, and changes in her body odour, but had no complaints about her pubic hair growth and any vaginal discharge. Laboratory findings shown high level in fertility hormones and level of bone age is equal to 10-year-old girl. Patient then had begun to receive monthly therapy of Leuprolide.

Conclusion

Detailed history taking on chronological order of thelarche, pubarche, menarche, and adrenarche, followed by assessment on family history, nutritional history, child developmental history, medication history, and neurological complaints should be done in order to diagnose precocious puberty. Physical examination and other examination of bone age determination, Luteinizing Hormone and Follicle-Stimulating Hormone level, and pelvic ultrasound are essentials in defining the diagnosis and treatment. Leuprolide is indicated for Central Precocious Puberty patient who have advanced bone age at the time of initial evaluation. As a clinician, it is necessary to diagnose precocious puberty as soon as possible to have good prognosis for the patient.
Heidegger’s Typewriter
Authors: Polt Richard ,   The Heidegger Circle
Published: November 2022

The discovery of a 1932 typewriter apparently signed by Heidegger raises questions about its authenticity and purpose, and prompts us to reconsider the validity of Heidegger’s portrayal of typewriters as devices that alienate writing from the hand and exemplify the modern oblivion of being.
Tumor Microenvironment Prognostic Risk and Its Association With MUC5AC in Ampullary Carcinoma
Authors: Jun Sun-Young , Lee Eui-Jin , Kim Sang-Il , An Soyeon
Published: November 2022

Context.—

The tumor-host interaction in the tumor microenvironment (TME) affects the prognosis of patients with malignant tumors. TME assessed via tumor budding (BD) and tumor-infiltrating lymphocyte (TIL) had a prognostic impact in patients with nonampullary small intestinal and colorectal carcinomas. In ampullary carcinoma (AC), MUC5AC was recently revealed as a significant prognosticator, but studies about the TME have not been conducted.

Objective.—

To assess TME-based prognostic risk in AC.

Design.—

We generated a collective TME risk index based on high-grade BD at the invasive front (BD3) and high density of stromal-TIL (>5%) in 64 surgically resected ACs. We evaluated its predictive values for overall survival (OS) and recurrence-free survival (RFS). We also investigated the relationship of TME to MUC5AC expression.

Results.—

TME prognostic risk index was classified into low-risk (BDLow/TILHigh; 26 of 64; 41%), intermediate-risk (BDLow/TILLow or BDHigh/TILHigh; 23; 36%), and high-risk (BDHigh/TILLow; 15; 23%) groups. Higher TME prognostic risk was associated with higher tumor grade (P = .03), lymphovascular invasion (P = .05), and MUC5AC immunopositivity (P = .02). TME prognostic risk index displayed better predictive ability for both OS (53.9 versus 46.1 versus 42.2) and RFS (24.8 versus 16.9 versus 15.3) than BD or TIL alone. In multivariate analysis, TME prognostic risk index was an independent prognosticator for OS (P = .003) and RFS (P = .03).

Conclusions.—

TME risk index in combination with BD and TIL was a stronger predictor of prognostic risk stratification than either BD or TIL alone for both OS and RFS in patients with AC. MUC5AC may modulate the interaction between tumor cells and immunity toward enhancing invasiveness in TME.
Copy Number Loss at Chromosome 14q11.2 Correlates With the Proportion of T Cells in Biopsies and Helps Identify T-Cell Neoplasms
Authors: Saglam Arzu , Singh Kunwar , Kumar Jyoti , Gollapudi Sumanth , Mukherjee Soham , Singh Amol , Butzmann Alexandra , Kaplan Lawrence , Andreadis Charambalos , Ai Weiyun Z. , Fakhri Bita , Rajkovic Aleksander , Wen Kwun Wah , Onodera Courtney , Van Ziffle Jessica , Devine Patrick W. , Ohgami Robert S.
Published: November 2022

Context.—

Evidence of T-cell clonality is often critical in supporting the diagnosis of a T-cell lymphoma.

Objectives.—

To retrospectively explore the significance of copy number losses at the 14q11.2 T-cell receptor α locus in relation to the presence of a T-cell neoplasm and proportion of T cells by targeted next-generation sequencing.

Design.—

Targeted next-generation sequencing data from 139 tissue biopsies, including T-cell lymphomas, B-cell lymphomas, classic Hodgkin lymphomas, nonhematopoietic malignancies, and normal samples, were reviewed for copy number losses involving the T-cell receptor α gene segments at chr14q11.2.

Results.—

We found that biallelic or homozygous deletion of 14q11.2 was found in most (28 of 33, 84.8%) T-cell lymphomas. The magnitude of 14q11.2 loss showed a statistically significant correlation with the proportion of T cells in lymphoma tissue samples. Copy number losses could also be detected in other lymphomas with high numbers of T cells (8 of 32, 25% of B-cell lymphomas, 4 of 4 classical Hodgkin lymphomas), though biallelic/homozygous deletion of 14q11.2 was not significantly observed outside of T-cell lymphomas. Most nonhematopoietic neoplasms and normal tissues (59 of 64, 92.2%) showed no significant copy number losses involving the T-cell receptor α locus at chr14q11.2.

Conclusions.—

Analysis of copy number losses at the T-cell receptor α locus chr14q11.2 with targeted next-generation sequencing can potentially be used to estimate the proportion of T cells and detect T-cell neoplasms.
The Initial Cost of a Construction in Tax Accounting: Fiscal Uncertainty and a Mechanism for its Elimination.
Authors: Zharkov Ruslan Aleksandrovich
Published: November 2022

The problem of the lack of legislative certainty regarding the formation of the initial cost of a construction object in tax accounting made it possible to identify the purpose of the article - the analysis of fiscal uncertainty regarding the formation of the initial cost of a construction object and the search for a mechanism to eliminate it. Achieving this goal required solving a number of tasks, including: analysis of existing rules and approaches to determining the initial cost of a construction object in tax accounting; identification of tax risks of uncertainty of including costs in the initial cost of a construction object for construction companies; development of a methodical approach to determining the initial cost of a construction object. The object of scientific work is a set of socio-economic relations that arise in the process of applying tax legislation on tax accounting in construction. The subject of the study is the initial cost of a construction object in tax accounting. The novelty of the work lies in identifying the problematic aspects of the current approaches to determining the initial cost of a construction object in tax accounting, as well as in proposing measures to eliminate them. The main conclusions of the study can be considered as follows. There is no direct relationship between the types of construction costs that form the initial cost and the construction object. Three categories of costs for construction companies have been identified in terms of inclusion in the initial cost of a construction project: those that do not cause uncertainty, that are controversial, and that are not reflected in the clarifications of the authorities. It is proposed to create an electronic service of the Federal Tax Service of the Russian Federation, containing three subsections (analytical tools, methodological tools, consulting services). The service will significantly reduce the degree of fiscal uncertainty in determining the initial cost of a construction project for construction companies.
The Image of BRICS in Latin American Media (Cases of Argentina and Mexico)
Authors: Kleshchenko Liudmila Leonidovna
Published: November 2022

The subject of the study is the image of BRICS in the Argentine and Mexican media. In the modern world, the role of multilateral institutions, including the BRICS group, is increasing. In 2022, Argentina applied to join the BRICS. In the context of the restructuring of the entire architecture of the system of international relations, the development of cooperation with the "Global South", as the leader of which the BRICS is positioned, seems extremely relevant for many countries of the world. In turn, such cooperation is impossible without the formation and strengthening of a positive image of BRICS in developing countries, among which Latin American states play an important role. The research is based on a constructivist methodology, according to which the image of the state or other political actor is a social construct created discursively. The purpose of the article is to identify the specifics of the image of the BRICS in the Argentine and Mexican media. The chronological framework of the study includes the period from 2014 to 2022. Research method: content analysis. The author comes to the following conclusions. Firstly, the image of BRICS in the Argentine and Mexican media is mostly positive. In addition to informational messages, they publish analytical materials in which BRICS is considered as one of the influential actors in global politics. Secondly, the range of opinions and assessments of BRICS in the sources is heterogeneous, which speaks, first of all, about the pluralism of Latin American media. The sources considered pay great attention to Brazil as the only Latin American country that is part of the BRICS, and Argentina as the only Spanish-speaking country that is preparing to become a member of the BRICS.
Annual Report 2020
Authors: Andreassen Karin
Published: November 2022

CAGE investigates methane release, a greenhouse gas far stronger than CO2, from the Arctic seafloor. Vast amounts of methane are trapped at shallow depths below the seafloor as gas hydrates, ice-like mixtures of gas and water. Current ocean warming makes these shallow greenhouse gas reservoirs particularly vulnerable to thawing. CAGE investigates the processes involved and implications for the Arctic climate and environment.
Annual Report 2019
Authors: Andreassen Karin
Published: November 2022

CAGE investigates methane release, a greenhouse gas far stronger than CO2, from the Arctic seafloor. Vast amounts of methane are trapped at shallow depths below the seafloor as gas hydrates, ice-like mixtures of gas and water. Current ocean warming makes these shallow greenhouse gas reservoirs particularly vulnerable to thawing. CAGE investigates the processes involved and implications to the Arctic climate and environment.
Forecasting Potential Evapotranspiration Using Seasonal ARIMA Model for Northern Telangana Zone, India
Authors: Guguloth Pragna , Premkumara . , Basavareddy . , Patil Rahul , Gowdar Polis
Published: November 2022

Present study aims to predict the evapotranspiration values over the Northern Telangana Zone through the identification or patterns in correlated data trends and seasonal variation and to assess the accuracy of the forecasting model. Plans for managing crop water consumption include potential evapotranspiration heavily. As a result, in a semi-arid environment, forecasting of the potential evapotranspiration is the foundation of any successful water resources management plans. The Thronthwaite method was used to estimate daily evapotranspiration, and a Seasonal Auto Regressive Integrated Moving Average was used to forecast potential evapotranspiration. Time series analysis of evapotranspiration data set showed a seasonality behaviour and thus Seasonal ARIMA model with the least Akaike Information Criteria (AIC) and Bayesian Information Criteria (BIC) values were selected. The Seasonal Arima model selected for the districts Adilabad, Jagtial, Karimnagar, KumuramBheem, Nirmal, and Peddapalli was (2,0,2)(2,1,0)12 and  for Nizamabad district (2,0,2)(1,1,0)12. Basic statistical properties are used to compare the observed and forecasted data which shown that that there is no significant difference between the mean values of the observed and predicted data at a 5% significance level. Hence the developed model was optimum to forecast the evapotranspiration over the study area and to sustain the forecasting accuracy.
Intra Articular Corticosteroid Injection in Rheumatoid Arthritis Patients
Authors: Elshentenawy Esraa Abdelhamid , Elsergany Mervat , Elsaadany Hanan , Eid Mananl
Published: November 2022

Objectives: This study was done to assess the effect of intra-articular injection of corticosteroid in persistent synovitis in rheumatoid arthritis (RA) patients.

Methods: Thirty RA patients with persistent synovitis in one joint were subjected to intra-articular injection of corticosteroid. All patients were examined for disease activity by disease activity score 28 (DAS28), functional assessment using the Modified Health Assessment Questionnaire (MHAQ), and laboratory investigations (erythrocyte sedimentation rate and C-reactive protein). Affected joints were evaluated for pain by visual analog scale (VAS) and tenderness score. Follow-up of the patients was done at 2 months after injection by clinical, functional and laboratory.

Results: There was a significant improvement in VAS, tenderness score, DAS 28, MHAQ after 2 months of injection.

Conclusion: Intra-articular injection of corticosteroid is a safe and effective treatment option in persistent synovitis in rheumatoid arthritis patients.
Active vs Traditional Methods of Recruiting Children for a Clinical Trial in Rural Primary Care Clinics
Authors: Darden Paul M. , Davis Ann M. , Lee Jeannette Y. , Bimali Milan , Simon Alan E. , Atz Andrew M. , Lim Crystal S. , Phan Thao-Ly T. , Roberts James R. , McCulloh Russell J. , Pyles Lee , Shaffer Michelle , Snowden Jessica N.
Published: November 2022

Importance

To our knowledge, there are no published randomized clinical trials of recruitment strategies. Rigorously evaluated successful recruitment strategies for children are needed.

Objective

To evaluate the feasibility of 2 recruitment methods for enrolling rural children through primary care clinics to assess whether either or both methods are sufficiently effective for enrolling participants into a clinical trial of a behavioral telehealth intervention for children with overweight or obesity.

Design, Setting, and Participants

This cluster-randomized clinical trial of 2 recruitment methods was conducted at 4 primary care clinics in 4 separate states. Each clinic used both recruitment methods in random order. Clinic eligibility criteria included at least 40% pediatric patients with Medicaid coverage and at least 100 potential participants. Eligibility criteria for children included a rural home address, age 6 to 11 years, and body mass index at or above the 85th percentile. Recruitment began February 3, 2020, and randomization of participants occurred on August 17, 2020. Data were analyzed from October 3, 2021, to April 21, 2022.

Interventions

Two recruitment methods were assessed: the active method, for which a list of potential participants seen within the past year at each clinic was generated through the electronic health record and consecutively approached by research staff based on visit date to the clinic, and the traditional method, for which recruitment included posters, flyers, social media, and press release. Clinics were randomized to the order in which the 2 methods were implemented in 4-week periods, followed by a 4-week catch-up period using the method found most effective in previous periods.

Main Outcomes and Measures

For each recruitment method, the number and proportion of randomized children among those who were approached was calculated.

Results

A total of 104 participants were randomized (58 girls [55.8%]; mean age, 9.3 [95% CI, 9.0-9.6] years). Using the active method, 535 child-parent dyads were approached and 99 (18.5% [95% CI, 15.3%-22.1%]) were randomized. Using the traditional method, 23 caregivers expressed interest, and 5 (21.7% [95% CI, 7.5%-43.7%]) were randomized. All sites reached full enrollment using the active method and no sites achieved full enrollment using the traditional method. Mean time to full enrollment was 26.3 (range, 21.0-31.0) days.

Conclusions and Relevance

This study supports the use of the active approach with local primary care clinics to recruit children with overweight and obesity from rural communities into clinical trials.

Trial Registration

ClinicalTrials.gov Identifier: NCT04142034
Poverty, Cortical Structure, and Psychopathologic Characteristics in Adolescence
Authors: Kim Hannah H. , McLaughlin Katie A. , Chibnik Lori B. , Koenen Karestan C. , Tiemeier Henning
Published: November 2022

Importance

Childhood poverty has been associated with increased internalizing and externalizing problems in adolescence, a period of peak onset for psychiatric problems. The underlying neural mechanisms remain unclear because longitudinal studies of poverty, brain structure, and changes in psychiatric symptoms are lacking.

Objective

To examine whether structural differences in cortical regions mediate the association between household poverty and change in psychiatric symptoms in early adolescence.

Design, Setting, and Participants

This longitudinal cohort study used baseline and 1-year follow-up data from the Adolescent Brain Cognitive Development Study. Children aged 9 to 10 years in the US were enrolled between September 1, 2016, and October 15, 2018. Data analysis was performed from August 13, 2021, to September 30, 2022.

Exposures

Household poverty as measured by income-to-needs ratio, which incorporates family income and adjusts for family size as a percentage of the federal poverty level.

Main Outcomes and Measures

Mediators were children’s cortical surface area, thickness, and volume, obtained using magnetic resonance imaging. Internalizing and externalizing problems at 1-year follow-up were outcomes measured by maternal report using the Child Behavior Checklist. Analyses were adjusted for baseline psychiatric problems and sociodemographic variables, including sex, race and ethnicity, parental educational level, and study site.

Results

Of the 7569 children (mean [SD] age, 9.91 [0.62] years; 3970 boys [52.5%]) included in the analysis, 1042 children (13.8%) lived below the poverty threshold between 2016 and 2018. Poverty was associated with increased externalizing symptoms score at 1-year follow-up (b = 1.57; 95% CI, 1.14-1.99), even after adjustment for baseline externalizing symptoms (b = 0.35; 95% CI, 0.06-0.64). The longitudinal associations of poverty with increases in externalizing problems over time were mediated by reductions in surface area in multiple cortical regions that support executive functioning (middle frontal gyrus), decision-making (lateral orbitofrontal cortex), visual processing (fusiform gyrus), auditory processing (transverse temporal gyrus), and emotion and language processing (superior temporal gyrus).

Conclusions and Relevance

The findings of this study suggest that childhood poverty is associated with increases in externalizing problems, but not internalizing problems, over time in early adolescence. This association is mediated by reductions in cortical surface area across numerous brain regions. These findings highlight potential neurobiological mechanisms underlying the link between poverty and the emergence of externalizing problems during early adolescence.
Marine‐Derived Hydrogels for Biomedical Applications
Authors: Lin Xiang , Wang Jinglin , Wu Xiangyi , Luo Yuan , Wang Yongan , Zhao Yuanjin
Published: November 2022

Marine organisms provide novel and broad sources for the preparations and applications of biomaterials. Since the urgent requirement of bio‐hydrogels to mimic tissue extracellular matrix (ECM), the natural biomacromolecule hydrogels derived from marine sources have received increasing attention. Benefiting from their outstanding bioactivity and biocompatibility, many attempts have been made to reconstruct ECM components by applying marine‐derived natural hydrogels. Moreover, marine hydrogels have been successfully applied in biomedicine by means of microfluidics, electrospray, and bioprinting. In this review, the classification and characteristics of marine‐derived hydrogels are summarized. In particular, their role in the development of biomaterials is also introduced. Then, the recent advances in bio‐fabrication strategies for various hydrogel materials are focused upon. Besides, the influences of hydrogel types on their functions in biomedical applications are discussed in depth. Finally, critical reflections on the limitations and future development of marine‐derived hydrogels are presented.
In Situ Deformation Topology of COFs with Shortened Channels and High Redox Properties for Li–S Batteries
Authors: Wang Qiaomu , Tang Kaifei , Liao Qiaobo , Xu Yang , Xu Haocheng , Wang Yandong , Wang Peng , Meng Zhen , Xi Kai
Published: November 2022

Covalent organic frameworks (COFs) with various topologies are typically synthesized by selecting and designing connecting units with rich shapes. However, this process is time‐consuming and labour‐intensive. Besides, the tight stacking of COFs layers greatly restrict their structural advantages. It is crucial to effectively exploit the high porosity and active sites of COFs by topological design. Herein, for the first time, inducing in situ topological changes in sub‐chemometric COFs by adding graphene oxide (GO) without replacing the monomer, is proposed. Surprisingly, GO can slow down the intermolecular stacking and induce rearrangement of COFs nanosheets. The channels of D‐ [4+3] COFs are significantly altered while the stacking of periodically expanded framework is weakened. This not only maximizes the exposure of pore area and polar groups, but also shortens the channels and increases the redox activity, which enables high loading while enhancing host‐guest interactions. This topological transformation to exhibit the structural features of COFs for efficient application is an innovative molecular design strategy.
Dapagliflozin‐Loaded Exosome Mimetics Facilitate Diabetic Wound Healing by HIF‐1α‐Mediated Enhancement of Angiogenesis
Authors: Zhang Weiyue , Wang Lutong , Guo Haoyu , Chen Lulu , Huang Xin
Published: November 2022

Angiogenesis plays a critical role in diabetic wound healing. However, no effective strategies have been developed to target endothelial cells (ECs) to facilitate diabetic wound healing. Dapagliflozin (DA) as a sodium‐glucose linked transporter 2 (SGLT2) inhibitor, may promote neovascularization in diabetic mice via HIF‐1α‐mediated enhancement of angiogenesis. Here, the bioinspired nanovesicles (NVs) prepared from induced pluripotent stem cells‐derived ECs through an extrusion approach are reported, which can function as exosome mimetics to achieve targeted deliver of DA. Abundant membrane C‐X‐C motif chemokine receptor 4 conferred the EC‐targeting ability of these NVs and the endothelial homology facilitated the accumulation in ECs. Furthermore, these DA‐loaded induced pluripotent stem cells (iPSC)‐EC NVs can facilitate angiogenesis and diabetic wound healing by HIF‐1α/VEGFA pathway. Taken together, this study indicated that targeting ECs and regulating angiogenesis may be a promising strategy for the treatment of diabetic wound healing.
Stamp‐Like Energy Harvester and Programmable Information Encrypted Display Based on Fully Printable Thermoelectric Devices
Authors: Zhang Xingzhong , Hou Yue , Yang Yang , Wang Ziyu , Liang Xiaosa , He Qingqing , Xu Yufeng , Sun Xiaolong , Ma Hongyu , Liang Jing , Liu Yong , Wu Wei , Yu Hongyu , Guo Haizhong , Xiong Rui
Published: November 2022

Thermoelectric (TE) devices exhibit considerable application potential in Internet of Things and personal health monitoring systems. However, TE self‐powered devices are expensive and their fabrication process is complex. Therefore, large‐scale preparation of the TE devices remains challenging. In this work, simple screen‐printing technology is used to fabricate a user‐friendly and high‐performance paper‐based TE device, which can be used in both stamp‐like paper‐based TE generators and infrared displays. When used as a paper‐based TE generator, an output power of 940.8 µW is achieved with a temperature difference of 40 K. The programmable infrared pattern based on the TE array display could be used to realize encryption and anti‐counterfeiting properties. Moreover, a visual extraction algorithm is used to develop a mobile application for processing and decoding the infrared quick response code information. These findings offer an exciting approach to using paper‐based TEGs in applications such as energy harvesting devices, optical encryption, anti‐counterfeiting, and dynamic infrared display.
In Situ Interweaved High Sulfur Loading Li–S Cathode by Catalytically Active Metalloporphyrin Based Organic Polymer Binders
Authors: Yao Xiaoman , Guo Can , Song Chunlei , Lu Meng , Zhang Yuluan , Zhou Jie , Ding Hui‐Min , Chen Yifa , Li Shun‐Li , Lan Ya‐Qian
Published: November 2022

The elaborate design of powerful Li–S binders with extended‐functions like polysulfides adsorption/catalysis and Li+ hopping/transferring in addition to robust adhesion‐property has remained a challenge. Here, an in situ cathode‐interweaving strategy based on metalloporphyrin based covalent‐bonding organic polymer (M‐COP, M = Mn, Ni, and Zn) binders is reported for the first time. Thus‐produced functional binders possess excellent mechanical‐strengths, polysulfides adsorption/catalysis, and Li+ hopping/transferring ability. Specifically, the modulus of Mn‐COP can reach up to ≈54.60 GPa (≈40 times higher than poly(vinylidene fluoride)) and the relative cell delivers a high initial‐capacity (1027 mAh g‐1, 1 C and 913 mAh g‐1, 2 C), and excellent cycling‐stability for >1000 cycles even at 4 C. The utilization‐rate of sulfur can reach up to 81.8% and the electrodes based on these powerful binders can be easily scale‐up fabricated (≈20 cm in a batch‐experiment). Noteworthy, Mn‐COP based cell delivers excellent capacities at a high sulfur‐loading (8.6 mg cm‐2) and low E/S ratio (5.8 µL mg‐1). In addition, theoretical calculations reveal the vital roles of metalloporphyrin and thiourea‐groups in enhancing the battery‐performance.
Scalable Alkaline Zinc‐Iron/Nickel Hybrid Flow Battery with Energy Density up to 200 Wh L−1
Authors: Yu Donglei , Zhi Liping , Zhang FeiFei , Song Yang , Wang Qing , Yuan Zhizhang , Li Xianfeng
Published: November 2022

Achieving net‐zero emissions requires low‐cost and reliable energy storage devices that are essential to deploy renewables. Alkaline zinc‐based flow batteries such as alkaline zinc‐iron (or nickel) flow batteries are well suited for energy storage because of their high safety, high efficiency, and low cost. Nevertheless, their energy density is limited by the low solubility of ferro/ferricyanide and the limited areal capacity of sintered nickel electrodes. Here, combining the electrochemical reaction with the chemical reaction of ferro/ferricyanide couple in a homemade nickel electrode, an alkaline zinc‐iron/nickel hybrid flow battery with a high energy density of 208.9 Wh L−1 and an energy efficiency of 84.7% at a high current density of 80 mA cm−2 is reported. The reversible chemical reactions between dual couples are proven to stabilize the nickel electrode by promoting the activation of the nickel electrode and further preventing the formation of γ‐NiOOH. A kW‐scale stack is demonstrated by the integration of ferro/ferricyanide couple with nickel electrode, delivering a coulombic efficiency of 98% and an energy efficiency of 89% at 40 mA cm−2. This work demonstrates a promising pathway for constructing and upscaling flow batteries with high energy density and low cost.
Preferred Orientation Evolution of Hole Transport Materials for High Emitting Dipole Orientation Ratio of the Emitting Material
Authors: Lee Heui‐Dong , Jang Ho Jin , Baek Ji Ho , Kim Jeom‐Jae , Choi Hyun Chul , Kim Jae‐Min , Lee Jun Yeob
Published: November 2022

Control of the molecular orientation is an effective approach to enhance the performance of organic light‐emitting diodes. This study examines the molecular dipole orientation of hole transport materials depending on the deposition step and the consecutive effect on the transition dipole orientation of the emitting dopant. In contrast to other reference materials, 4,4′,4′′‐tris(carbazole‐9‐yl)triphenylamine (TCTA) shows a preferred orientation only in the continuously deposited films that is dependent on the film thickness. The horizontal dipole orientation ratio of the emitting dopant deposited on the TCTA is improved by the alignment of TCTA molecules. The power efficiency of the device produced from the above materials is increased from 28.9 to 34.4 lm W−1owing to the dual enhancement of the hole mobility of TCTA and the horizontal dipole orientation ratio of the emitting dopant. The molecular orientation of the charge transport layer contributes to charge transport in the layer and the molecular orientation of the adjacent emitting layer.
Targeted xCT‐mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti‐PD‐1/L1 Response
Authors: Tang Bufu , Zhu Jinyu , Wang Yajie , Chen Weiqian , Fang Shiji , Mao Weiyang , Xu Ziwei , Yang Yang , Weng Qiaoyou , Zhao Zhongwei , Chen Minjiang , Ji Jiansong
Published: November 2022

Tumor‐associated macrophages (TAMs) play an essential role in tumor progression, metastasis, and antitumor immunity. Ferroptosis has attracted extensive attention for its lethal effect on tumor cells, but the role of ferroptosis in TAMs and its impact on tumor progression have not been clearly defined. Using transgenic mouse models, this study determines that xCT‐specific knockout in macrophages is sufficient to limit tumorigenicity and metastasis in the mouse HCC models, achieved by reducing TAM recruitment and infiltration, inhibiting M2‐type polarization, and activating and enhancing ferroptosis activity within TAMs. The SOCS3‐STAT6‐PPAR‐γ signaling may be a crucial pathway in macrophage phenotypic shifting, and activation of intracellular ferroptosis is associated with GPX4/RRM2 signaling regulation. Furthermore, that xCT‐mediated macrophage ferroptosis significantly increases PD‐L1 expression in macrophages and improves the antitumor efficacy of anti‐PD‐L1 therapy is unveiled. The constructed Man@pSiNPs‐erastin specifically targets macrophage ferroptosis and protumoral polarization and combining this treatment with anti‐PD‐L1 exerts substantial antitumor efficacy. xCT expression in tumor tissues, especially in CD68+ macrophages, can serve as a reliable factor to predict the prognosis of HCC patients. These findings provide further insight into targeting ferroptosis activation in TAMs and regulating TAM infiltration and functional expression to achieve precise tumor prevention and improve therapeutic efficacy.
A Green Route to Benzyl Phenyl Sulfide from Thioanisole and Benzyl Alcohol over Dual Functional Ionic Liquids
Authors: Wu Fengtian , Wang Yuepeng , Qian Yong , Xie Zong‐Bo , Ke Zhengang , Zhao Yanfei , Liu Zhimin
Published: November 2022

Benzyl phenyl sulfide is a kind of important chemicals with wide usage, which is mainly prepared through a nucleophilic reaction of thiophenol with benzyl chlorides or benzyl alcohols, suffering from inherent drawbacks, such as low efficiency, requirements for equivalent acid or base catalysts and formation of harmful byproducts and waste. Herein, we report a green route to access various benzyl phenyl sulfide derivatives in good to excellent yields under mild conditions via the reaction of thioanisoles with benzyl alcohols over ionic liquid 1‐propylsulfonate‐3‐methylimidazolium trifluoromethanesulfonate ([SO3HPrMIm][OTf]). Mechanism investigation indicates that the synergic effect of cation and anion of [SO3HPrMIm][OTf] activates thioanisoles and benzyl alcohols via hydrogen bonding, thus catalyzes the dehydration of benzyl alcohol to dibenzyl ether and the subsequent metathesis reaction between dibenzyl ether and benzyl phenyl sulfide, finally generating benzyl phenyl sulfide derivatives. This is a simple, highly efficient, and green approach to produce benzyl phenyl sulfide derivatives, which has promising application potentials.
Ag‐induced Phase Transition of Bi2O3 Nanofibers for Enhanced Energy Conversion Efficiency towards Formate in CO2 Electroreduction
Authors: Wang Xin , He Wenhui , Shi Jialin , Junqueira João R. C. , Zhang Jian , Dieckhöfer Stefan , Seisel Sabine , Das Debanjan , Schuhmann Wolfgang
Published: November 2022

Bi‐based electrocatalysts have been widely investigated in the CO2 reduction reaction (CO2RR) for the formation of formate. However, it remains a challenge to achieve high Faradaic efficiency (FE) and industrial current densities at low overpotentials for obtaining both high formate productivity and energy efficiency (EE). Herein, we report an Ag−Bi2O3 hybrid nanofiber (Ag−Bi2O3) for highly efficient electrochemical reduction of CO2 to formate. Ag−Bi2O3 exhibits a formate FE of >90% for current densities from −10 to −250 mA ⋅ cm−2 and attains a yield rate of 11.7 mmol ⋅ s−1 ⋅ m−2 at −250 mA ⋅ cm−2. Moreover, Ag−Bi2O3 increased the EE (52.7%) by nearly 10% compared to a Bi2O3 only counterpart. Structural characterization and in‐situ Raman results suggest that the presence of Ag induced the conversion of Bi2O3 from a monoclinic phase (α‐Bi2O3) to a metastable tetragonal phase (β‐Bi2O3) and accelerated the formation of active metallic Bi at low overpotentials (at > −0.3 V), which together contributes to the highly efficient formate formation.
Texts, Practice and Practitioners: Computational Cultures at Work in Early Modern South India**
Authors: Senthil Babu D.
Published: November 2022

This essay will discuss the hegemonic role that texts have come to play in the historiography of subcontinental mathematical traditions. It will argue that texts need to be studied as records of practices of people's working lives, grounded in social hierarchies. We will take particular mathematical texts to show how different occupational registers have come to shape practices that defy the binaries of concrete and abstract, high and low mathematics or the pure and applied conundrum. Measuring, counting and accounting practices as part of the routine work of practitioners performing their caste occupations then provide us with a spectrum of the computational activities that controlled and regulated the lives of people in the past. In the process the act of computing itself gained certain political values such as cunning and manipulation, identified with professions of village accountant and merchant, for example. Drawn from my earlier work on these records, I discuss the occupational role of the accountant as a political functionary who assessed and authenticated the measurements of land and produce in the village, making values of the labor performed by others, and creating avenues for his own proficiency as a mathematical practitioner.
Advances in biomimetic collagen mineralisation and future approaches to bone tissue engineering
Authors: Doyle Michael Eugene , Dalgarno Kenny , Masoero Enrico , Ferreira Ana Marina
Published: November 2022

With an ageing world population and ~20% of adults in Europe being affected by bone diseases, there is an urgent need to develop advanced regenerative approaches and biomaterials capable to facilitate tissue regeneration while providing an adequate microenvironment for cells to thrive. As the main components of bone are collagen and apatite mineral, scientists in the tissue engineering field have attempted in combining these materials by using different biomimetic approaches to favour bone repair. Still, an ideal bone analogue capable of mimicking the distinct properties (i.e., mechanical properties, degradation rate, porosity, etc.) of cancellous bone is to be developed. This review seeks to sum up the current understanding of bone tissue mineralisation and structure while providing a critical outlook on the existing biomimetic strategies of mineralising collagen for bone tissue engineering applications, highlighting where gaps in knowledge exist.
Conceptualising active management of paradoxical tensions in corporate sustainability: A systematic literature review
Authors: Alosi Alice , Annunziata Eleonora , Rizzi Francesco , Frey Marco
Published: November 2022

Despite the growing literature on paradox theory in corporate sustainability (CS), there is a lack of systematic analyses of both the antecedents and the maintenance of the active strategy for managing paradoxical tensions. This systematic literature review examines the individual, organisational and inter‐organisational antecedents, hereinafter roots of paradoxes (RPs), behind the active strategies aimed at managing paradoxical tensions in CS. The paper also analyses the active and defensive strategies used to manage paradoxical tensions at the organisational level, considering the role of both organisational strategic levels (corporate, business, tactical and operational) and inter‐organisational relationships. This review provides an integrative framework of the individual, organisational and inter‐organisational RPs and practices favouring the adoption of active strategies for managing paradoxical tensions. The analysis of the dynamics of transition from active to defensive strategies also highlights that the long‐term implementation of the active strategy requires its stratification within the organisational strategic levels. This study contributes to the literature on paradox theory in CS by understanding the mechanisms that sustain active management. Managerial implications are also illustrated.
Macromolecular nanoparticles to attenuate both reactive oxygen species and inflammatory damage for treating Alzheimer's disease
Authors: Zhang Bosong , Zhao Yufang , Guo Kai , Tian Hui , Wang Cao , Wang Ruiqi , Chen Yue , Chen Xiongbiao , Zheng Hongxia , Gao Bingxin , Shen Jieyi , Tian Weiming
Published: November 2022

Prevention and early intervention are the current focus of treatment for Alzheimer's disease (AD). An increase in reactive oxygen species (ROS) is a feature of the early stages of AD, thus suggesting that the removal of excess ROS can be a viable method of improving AD. Natural polyphenols are able to scavenge ROS and thus promising for treating AD. However, some issues need to be addressed. Among them, important are that most polyphenols are hydrophobic, have low bioavailability in the body, are easily degraded, and that single polyphenols have insufficient antioxidant capacity. In this study, we employed two polyphenols, resveratrol (RES) and oligomeric proanthocyanidin (OPC), and creatively grafted them with hyaluronic acid (HA) to form nanoparticles to address the aforementioned issues. Meanwhile, we strategically grafted the nanoparticles with the B6 peptide, enabling the nanoparticles to cross the blood–brain barrier (BBB) and enter the brain for AD treatment. Our results illustrate that B6‐RES‐OPC‐HA nanoparticles can significantly scavenge ROS, reduce brain inflammation, and improve learning and memory ability in AD mice. B6‐RES‐OPC‐HA nanoparticles have the potential to prevent and alleviate early AD.