bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonlinear characteristics of the driving model of the coaxial integrated macro–micro composite actuator
Authors: Yu Caofeng , Wang Yu , Xiao Zhihao , Wu Gan , Duan Yongyong , Yang Kun
Published: October 2022

Abstract. Nonlinearity is one of the important factors affecting the
positioning accuracy of the macro–micro composite actuator. To improve the
positioning accuracy of the driving model of the macro–micro composite
actuator, this paper combines the research phenomenon of the nonlinear
characteristics of the voice coil motor to model the nonlinear factors that
affect the macro-moving part of the macro–micro composite actuator. Firstly,
based on analyzing its structure and working principle, the variation law of
the magnetic field intensity at the working air gap of the macro-motion part
is analyzed by the finite element method, and the driving force model of the
macro-motion part is established. Secondly, through the magnetic field
simulation analysis, there is a magnetization phenomenon in the mover part,
and the static friction model is established. Then, the experimental data are
acquired and processed by building the experimental test platform of the
actuator, and the variation model of the electromechanical time constant
with the macro-motion displacement is established. Then, combined with the
Stribeck model and the static friction model, the kinetic model of the
macro-motion part is established. Finally, using the least square method
identify the parameter model, the results are compared with the
experiment. The results show that the magnetic field distribution at the
working air gap of the macro-motion part of the macro–micro composite
actuator is relatively uniform, but it is related to the macro-motion
displacement and the macro-motion coil current. When the macro-motion part
of the macro-micro composite actuator starts, the friction model can
approximately reflect the change of friction force, the kinetic
model of the macro-motion part can reflect the dynamic characteristics of
the macro-motion part, and the matching degree is 92.97 %. The research
results lay a theoretical and technical foundation for the development of a
high-speed and large-stroke positioning controller of the macro-motion micro
composite actuator.
Effects of topographic and meteorological parameters on the surface area loss of ice aprons in the Mont Blanc massif (European Alps)
Authors: Kaushik Suvrat , Ravanel Ludovic , Magnin Florence , Yan Yajing , Trouve Emmanuel , Cusicanqui Diego
Published: October 2022

Abstract. Ice aprons (IAs) are part of the critical components of the Alpine cryosphere. As a result of the changing climate over the past few decades, deglaciation has resulted in a surface decrease of IAs, which has not yet been documented, except for a few specific examples. In this study, we quantify the effects of climate change on IAs since the mid-20th century in the Mont Blanc massif (western European Alps). We then evaluate the role of meteorological parameters and the local topography in the behaviour of IAs. We precisely mapped the surface areas of 200 IAs using high-resolution aerial and satellite photographs from 1952, 2001, 2012 and 2019. From the latter inventory, the surface area of the present individual IAs ranges from 0.001 to 0.04 km2. IAs have lost their surface area over the past 70 years, with an alarming increase since the early 2000s. The total area, from 7.93 km2 in 1952, was reduced to 5.91 km2 in 2001 (−25.5 %) before collapsing to 4.21 km2 in 2019 (−47 % since 1952). We performed a regression analysis using temperature and precipitation proxies to better understand the effects of meteorological parameters on IA surface area variations. We found a strong correlation between both proxies and the relative area loss of IAs, indicating the significant influence of the changing climate on the evolution of IAs. We also evaluated the role of the local topographic factors in the IA area loss. At a regional scale, factors like direct solar radiation and elevation influence the behaviour of IAs, while others like curvature, slope and size of the IAs seem to be rather important on a local scale.
Current status and grand challenges for small wind turbine technology
Authors: Bianchini Alessandro , Bangga Galih , Baring-Gould Ian , Croce Alessandro , Cruz José Ignacio , Damiani Rick , Erfort Gareth , Simao Ferreira Carlos , Infield David , Nayeri Christian Navid , Pechlivanoglou George , Runacres Mark , Schepers Gerard , Summerville Brent , Wood David , Orrell Alice
Published: October 2022

Abstract. While modern wind turbines have become by far the largest rotating
machines on Earth with further upscaling planned for the future, a renewed
interest in small wind turbines (SWTs) is fostering energy transition and smart
grid development. Small machines have traditionally not received the same
level of aerodynamic refinement as their larger counterparts, resulting in
lower efficiency, lower capacity factors, and therefore a higher cost of
energy. In an effort to reduce this gap, research programs are developing
worldwide. With this background, the scope of the present study is 2-fold.
In the first part of this paper, an overview of the current status of the
technology is presented in terms of technical maturity, diffusion, and cost.
The second part of the study proposes five grand challenges that are thought
to be key to fostering the development of small wind turbine technology in
the near future, i.e. (1) improving energy conversion of modern SWTs through
better design and control, especially in the case of turbulent wind; (2)
better predicting long-term turbine performance with limited resource
measurements and proving reliability; (3) improving the economic viability of
small wind energy; (4) facilitating the contribution of SWTs to the energy
demand and electrical system integration; (5) fostering engagement, social
acceptance, and deployment for global distributed wind markets. To tackle
these challenges, a series of unknowns and gaps are first identified and
discussed. Based on them, improvement areas are suggested, for which 10 key
enabling actions are finally proposed.
Muscle Architectural and Force-Velocity Curve Adaptations following 10 Weeks of Training with Weightlifting Catching and Pulling Derivatives
Authors: Suchomel Timothy J. , McKeever Shana M. , Nolen Justin D. , Comfort Paul
Published: October 2022

The aims of this study were to examine the muscle architectural, rapid force production, and force-velocity curve adaptations following 10 weeks of resistance training with either submaximal weightlifting catching (CATCH) or pulling (PULL) derivatives or pulling derivatives with phase-specific loading (OL). 27 resistance-trained men were randomly assigned to the CATCH, PULL, or OL groups and completed pre- and post-intervention ultrasound, countermovement jump (CMJ), and isometric mid-thigh pull (IMTP). Vastus lateralis and biceps femoris muscle thickness, pennation angle, and fascicle length, CMJ force at peak power, velocity at peak power, and peak power, and IMTP peak force and force at 100-, 150-, 200-, and 250 ms were assessed. There were no significant or meaningful differences in muscle architecture measures for any group (p > 0.05). The PULL group displayed small-moderate (g = 0.25-0.81) improvements in all CMJ variables while the CATCH group displayed trivial effects (g = 0.00-0.21). In addition, the OL group displayed trivial and small effects for CMJ force (g = -0.12-0.04) and velocity variables (g = 0.32-0.46), respectively. The OL group displayed moderate (g = 0.48-0.73) improvements in all IMTP variables while to PULL group displayed small-moderate (g = 0.47-0.55) improvements. The CATCH group displayed trivial-small (g = -0.39-0.15) decreases in IMTP performance. The PULL and OL groups displayed visible shifts in their force-velocity curves; however, these changes were not significant (p > 0.05). Performing weightlifting pulling derivatives with either submaximal or phase-specific loading may enhance rapid and peak force production characteristics. Strength and conditioning practitioners should load pulling derivatives based on the goals of each specific phase, but also allow their athletes ample exposure to achieve each goal.
Psikolojik Yıldırmanın Sebeplerinin İncelenmesi
Authors: ZORGÜL Garip Güler , YİĞİT Havva Seçil
Published: October 2022

In this study, it is aimed to contribute to the literature by focusing on the semantic integrity and causes of psychological intimidation imposed on psychological intimidation in the historical process. Psychological intimidation, for different reasons individuals working in workplaces are exceeded, the higher the integrity of the self and personality by position or equivalent in order to spiritually destroy and crush him, even immoral attitudes and behaviors of the general definition is given. In parallel with this conceptual framework, it is possible to define psychological intimidation in the form of harmful behavior, attitude, approach and pressure applied to those who work, experienced in workplaces, characterized by behaviors that are difficult to understand. There are three common causal focuses that are agreed on the main characteristics that arise from the definitions made in relation to the conceptual framework. The first of these is the effects that the action of the person who applies psychological intimidation leaves on the victim; the second is whether these negative behaviors harm the victim, and the third is the persistent attitude of the person or persons about continuing the psychological intimidation behavior. Key Words: Self-Integrity, Immorality, Psychological Intimidation
A fish market survey using a novel PCR-sequencing-based protocols for the identification of commercial significant fish species
Authors: Ali Ashraf , Di Taranto Pietro , Parisi Antonio , Del Sambro Laura , Iannacci Antonio , Belluscio Donatella , Debernardis Daniela Paola , Normanno Giovanni
Published: October 2022

This study developed a simple, specific, and affordable PCR-sequencing-COI gene-based protocol for the simultaneous identification of some important commercial fish species: Merluccius merluccius, Lates niloticus, Gadus morhua, Ruvettus pretiosus, Pangasianodon hypophthalmus, Epinephelus spp. For this study, a local market survey on fish was carried out to evaluate the application of labelling laws and to detect fraudulent actions using the developed PCR protocols. Ten specimens of each fish species of interest were obtained from wholesale fishery plants and were utilized for the protocol development. DNA was extracted from the individual samples and quantified. DNA isolates were subjected to end-point PCR and the PCR products were sequenced. For the identification of fish species, novel species-specific primers were developed by the program "Primer Express 3.0" and by the software “Primer-BLAST” to amplify fragments of 200 bp, 250 bp, 300 and 562 bp, 350 bp, 400 bp and 522 bp within the COI gene for M. merluccius, L. niloticus, G. morhua, R. pretiosus, P. hypophthalmus, Epinephelus spp., respectively. Single PCR was performed using DNA isolates and developed primers for each fish species of interest. After sequencing, the isolates were compared with the selected sequences of the COI gene and showed a similarity ranging from 99 to 100%. Among 43 samples obtained for the survey, 19 (44.2%) were mislabelled, with 18 (41.9%) mislabelled samples from local fisheries and fish marketplaces and 1 (2.32%) from hypermarket stores. Among fish samples purchased at local fisheries and fish marketplaces, fraudulent actions were observed more frequently in fish slices (100%) than fish fillets (65%). Regarding fish fillets, out of four samples labelled as grouper, three were L. niloticus and one P. hypophthalmus. Two fillets marketed as cod were substituted with L. niloticus.  Five samples labelled as “fillet” and two samples labelled as “perch” were identified as P. hypophthalmus. Regarding fish slices, all samples marketed as grouper (E. marginatus) were slices of R. pretiosus. The single case of mislabelling detected from fishery products purchased at hypermarket stores was a sample of “Spinycheek grouper” (Epinephelus diacanthus) that was indicated on label as “Grouper” (Epinephelus marginatus). In summary, our work highlights the need for continuous surveillance of the commercialization of fishery products, to reduce the number of fraud cases that happen in the market. Furthermore, our protocols based on PCR techniques could be useful for quality control of fresh finfish and to strengthen controls on the most frequent fraudulent actions of marketed fishery products.
PECULIARITIES OF MORPHOLOGICAL MECHANISMS OF ADAPTATION OF THE ENDOCRINE GLANDS IN MAMMALS IN THE TERRITORY OF HIGH RADIOACTIVE POLLUTION
AND RELIEF OF ANTHROPOGENIC LOAD
Authors: Fiadotau D.N.
Published: October 2022

The aim of the research was to conduct a comparative analysis of long-term studies (from 2016 to 2022) on mor-phological changes in the endocrine glands (thyroid gland and adrenal glands) in mammals (raccoon dog, river otter and white-breasted hedgehog) in the territory of high radioactive contamination and removal of anthropogenic load (in conditions of the Belarusian sector of the exclusion zone). The established morphological changes in the thyroid gland and adrenal glands in the studied mammals should be considered as a compensatory-adaptive reaction of the body aimed at maintaining metabolic homeostasis in the zone of radiation exposure.
MEAT PERFORMANCE OF FOREIGN SHEEP BREEDS IN THE REPUBLIC OF BELARUS
Authors: Grekova I.E.
Published: October 2022

The article contains the results of studies on meat performance of foreign mutton-wool sheep bred in the Republic of Belarus. The system of breeding work is analyzed. The research was performed in the RUE “Vitebsk Breeding Enterprise”, FLLC “Eastern Ship” of Logoisk district and OJSC “Zherebkovichi” of Lyakhovichi district, where breeding groups of mutton-wool producing sheep were formed. It is found that the breeding of foreign sheep breeds of Belarusian selection continues to be carried out according to the open breeding nucleus scheme with its active part influenced by the whole breeding herd under control. This breeding system in combination with the multi-stage selection of the resulting offspring ensures the expansion of genealogical structure and formation of new generations with better meat qualities.
MICROCLIMATE PARAMETERS IN THE SECTORS FOR HOUSING YOUNG FATTENING PIGS IN DIFFERENT SEASONS
Authors: Petrushko A.S. , Khodosovsky D.N. , Rudakovskaya I.I. , Bezmen V.A. , Slinko O.M.
Published: October 2022

Based on the results of the research conducted, graphical vertical and horizontal aerograms were developed for the most common types of ventilation and types of pig premises. In the course of the research, it was found that the air temperature in the sectors for housing young fattening pigs ranged within 18.9-22.6°C, the relative humidity was 58.1-76.7%, the air speed was 0.08-0.19 m/s, the concentration of ammonia was 5.4-13.7 mg/m3, oxygen – 17-19.9%, carbon dioxide – 0.14-0.20%, illumination – 70-298 lux, depending on the season of the year. In view of the foregoing, a comprehensive methodology for assessing the microclimate in industrial premises of pig farms and complexes was developed.
MEASURES TO IMPROVE THE PRODUCTIVITY OF FATTENING YOUNG PIGS ON LONG-TERM INDUSTRIAL COMPLEXES
Authors: Khodosovsky D.N. , Bezzubov V.I. , Khochenkov A.A. , Rudakovskaya I.I. , Bezmen V.A. , Petrushko A.S. , Solyanik A.N. , Matyushonok T.A. , Jumkova M.V. , Slinko O.M. , Belanovsky V.G.
Published: October 2022

This article contains the data of studies, the objective of which was to develop schemes of preventive drugs applica-tion in the fattening of young pigs on a long-term industrial complex with a limit-exceeding young pig waste due to “biological fatigue” of the premises. Probiotic, antimicrobial and anti-stress drugs application scheme developed on the basis of the data obtained made it possible to increase the average daily gain of fattening stock by 33 g and increase the production of pork by 5.4%.
COMPARATIVE FEEDER EFFICIENCY OF YOUNG CATTLE UNDER DIFFERENT HOUSING CONDITIONS
Authors: Schebetok I.V.
Published: October 2022

The article presents the results of research on the influence of housing conditions on the feeder efficiency of feedlot young cattle. When kept on a feedlot, a more intensive increase in live weight and a decrease in morbidity of young animals was established compared to the management of animal fattening in a stationary premise.
EVALUATION OF THE EFFECT OF AERATION ON THE GROWTH DYNAMICS OF THE TRICHOPHYTON FUNGUS IN A LIQUID MODIFIED GLUCOSE MEDIUM
Authors: Zaitseva V.V.
Published: October 2022

In the result of the conducted studies, it was found that the highest yield of biomass and microconidia in Tr. verru-cosum No. 130 and Tr. mentagrophytes No. 135 was observed at the rotation speed of the rocking platform of 250 rpm and the content in the flask of 100 cm3 of liquid modified glucose nutrient medium.
EVALUATION OF THE EFFECT OF MEDIUM TEMPERATURE AND EXPOSURE ON THE GROWTH
OF TRICHOPHYTON IN A LIQUID MODIFIED GLUCOSE MEDIUM
Authors: Zaitseva V.V.
Published: October 2022

The aim of the research is to study of the effect of medium temperature and exposure on the dynamics of Tri-chophyton spp. fungus growth and development during liquid-phase cultivation in modified glucose nutrient medium. In this experiment, the effect of exposure and environmental temperature on the accumulation of mycelial biomass and the biosynthesis of microconidia in Trichophyton fungus of different strains was studied.
In the course of the experiment, it was found that the most optimal physical parameters for growing Tr. verrucosum No. 130 and Tr. mentagrophytes No. 135 on a liquid modified glucose nutrient medium is a temperature of (28±2)°C and an exposure of 80 hours, while providing an increase in mycelium biomass of 1.33–1.34% and biosynthesis of microconidia 71.0-71.25 million/cm3 s viability 63.3–64.0%.
Impact of Dark Triad Personality Traits on Attitude Towards Infidelity among Married Individuals in Punjab
Authors: Bilal Ahmed , Naqvi Ghuncha , Mehmood Imran
Published: October 2022

The present study aims to measure the impact of dark triad personality traits on attitude towards infidelity among married individuals. The cross-sectional research design was employed in this study. Sample size was justified through Apriori sample size calculator. In total, 132 participants were selected from Multan, Bahawalpur, Lahore and Faisalabad using purposive sampling technique. Two questionnaires; Short Dark triad- SD3 (Jones & Paulhus, 2011) and Attitude toward Infidelity Scale (Whatley, 2006) were used for data collection. Data were analyzed using SPSS 25.0. The results revealed that dark triad personality traits including all subscales; machiavellianism, narcissism & psychopathy, was significantly positively correlated with Attitude toward infidelity. Dark triad personality traits were also found to be a significant predictor of attitude towards infidelity. Implications of the study along with its limitations were discussed and recommendations for future research have been suggested. Due to logistical limitations, this research was performed on a relatively small sample. This study will help to spread awareness among married people who directly or indirectly experience infidelity.
“They Shall Come into the Hollows of the Earth” (Isa 2:19): Bar Kokhba-Period Hiding Complexes at Biblical Tels—Tel Lavnin as a Case Study
Authors: Klein Eitan , Levy-Reifer Ayelet , Ganor Amir , Goldenberg Gideon , Hadad Ilan
Published: October 2022

Hiding complexes in Judea have been objects of considerable scholarly interest since the 1970s. By now, we are well acquainted with their main features and spatial distribution. Most hiding complexes in the Judean foothills were cut beneath the houses in Jewish villages. They were entered via shafts carved out of the nari rock, leading to underground passages quarried in the soft chalk beneath. Following recent intensive looting at Tel Lavnin, a site located in ‘Adullam Park, south of the Ela Valley, inspectors of the Antiquities Theft Prevention Unit of the Israel Antiquities Authority documented three hiding complexes. In this paper, we present these hiding complexes and the objects discovered in them. We discuss these complexes’ special architectural features and ponder why particular architectural methods were chosen. We then compare the complexes of Tel Lavnin to complexes documented elsewhere in Judea. We propose that they constitute an architectural subtype of hiding complexes from the Bar Kokhba Revolt and predict that others like them will be discovered in the future.
Caves in the Old Testament, the New Testament, and the Qur’an
Authors: Shivtiel Avihai
Published: October 2022

This article deals with the caves mentioned in the Old Testament, the New Testament, and the Qur’an. It highlights all the relevant occurrences of the Hebrew, Arabic, and Greek words for cave, discusses its etymologies, and provides brief details about the contexts in which it is mentioned.
The Effects of Hedonic vs. Meaningful Message Type and Time Units on the Persuasiveness of Concert Advertising
Authors:   Korean Association of Arts Management, Kim Seungeun , Youn Nara
Published: October 2022

This study was conducted to understand consumers’ concert ticket purchase behavior using an experimental approach and derived a practical sales promotion strategy. More specifically, we investigated an effective concert poster advertisement strategy utilizing a numerosity heuristics of the large versus small time unit matched with the hedonic versus utilitarian message appeal type. In the context of the Bangtan Boys, Study 1 showed that the interaction between time unit (30 days vs. 1 month) used for the ticket opening time and concert message type (meaning pleasure vs. meaning) enhances consumers’ interest in the concert. In Study 2, we showed that a significant interactive effect between the waiting time unit until the concert date (one week versus seven days) and the concert message on the consumers’ attitudes toward the concert was mediated by the joy of waiting. In conclusion, as a performance ticket promotion strategy, this research suggests that advertisement effectiveness can be improved by using a larger time unit for the hedonic appeal and by using a smaller time unit for the meaningful appeal.
Effect of Multimedia Instruction (MI) on Students’ Performance in Data Structures and Algorithms in Public Polytechnics in Nasarawa State
Authors: S.C. Onyema , I.F. Onyeka , N.U. Mukail
Published: October 2022

The study investigated the effect of multimedia instruction on students’ academic performance in Data Structures and Algorithms (DSA) in two public Polytechnics in Nasarawa State. The population of the study comprised one hundred and twenty (120) National Diploma one (NDI) students of Computer Science from Nasarawa State Polytechnic, Lafia (now Isa Mustapha Agwai I Polytechnic, Lafia) and Federal Polytechnic, Nasarawa. The study adopted a quasi-experimental research approach using the non-randomized control group pretest-posttest design. Intact classes were maintained and an experiment of two equivalent groups was designed—one was the experimental group while the other was the control group. The group was determined using a simple random sampling technique. Sixty eight (68) students in Nasarawa State Polytechnic, Lafia constituted the experimental group while fifty two (52) students in Federal Polytechnic Nasarawa constituted the control group. The experimental group was exposed to multimedia instruction (MI) on DSA while the control group was exposed to conventional instruction. The instrument for data collection was a DSA performance test titled ‘Data Structure PerfTest (DPT)’. The DPT contained 20 objective items from the topics treated. The reliability of the instrument was determined using the test-retest approach and a correlation coefficient of .87 was attained. Inferential statistics such as t-test was used to test the null hypothesis at 0.05 alpha level of significance. Data analysis was done using the statistical package for social science (SPSS). The finding showed that the treatment group (MI) performed significantly better than its counterpart in the control group which was exposed to conventional instruction. The study recommended expansive use of multimedia instruction in teaching and learning of Data Structures and Algorithms in tertiary institutions.
Midazolam nasal spray to treat intermittent, stereotypic episodes of frequent seizure activity: pharmacology and clinical role, a comprehensive review
Authors: Cornett Elyse M. , Nemomsa Meskerem A. , Turbeville Bailey , Busby Matthew A. , Kaye Jessica S. , Kaye Aaron J. , Choi JooHee , Ramírez Giovanni F. , Varrassi Giustino , Kaye Adam M. , Kaye Alan D. , Wilson James , Ganti Latha
Published: October 2022

An intranasal formulation of midazolam, Nayzilam, has been FDA-approved to treat intermittent, stereotypic episodes of frequent seizure activity. Nayzilam is easy to administer and can quickly treat seizures that occur outside of the hospital. The intra-nasal route of administration allows non-medical personal to administer the drug which makes it more accessible and user-friendly in the event of a seizure. Many studies have indicated quick cessation of seizures with Nayzilam compared to rectal diazepam, which has been the standard of care treatment. Nayzilam has been proven to be safe and effective for acute seizures in children, deeming it a revolutionary alternative in times where intravenous administration is not possible.
Mal di schiena: tre casi per tre malattie (infettive)
Authors: Troisi Angela , Mambeli Lorenzo , Del Vecchio Lucia , Altimari Luigi , Mazzieri Tamara , Dal Bo Sara , Minguzzi Mariateresa , Marchetti Federico
Published: October 2022

Back pain is an uncommon paediatric symptom and often manifests non-specifically, especially in younger children. Behind this insidious symptom lie multiple causes, such as trauma, infectious and inflammatory forms and malignant causes. Especially in forms of infectious origin, imaging takes on a key role. The paper reports three cases of back pain on an infectious basis (spondylodiscitis, sacroileitis and piomyositis) with the descriptions of their peculiar clinical characteristics, treatments and courses. The importance of nuclear magnetic resonance imaging is highlighted in guiding the therapeutic diagnostic procedure.
Farmaci antiemetici e bilancio tra benefici e rischi: il caso della metoclopramide
Authors: Caiazzo Roberta , Liguori Federica , Addeo Agnese Maria , Apicella Andrea , Coppola Crescenzo , Macchini Giulia , Tipo Vincenzo
Published: October 2022

An 8-year-old girl arrived in the Emergency Department presenting with sudden unilateral right trismus, deviation of the jaw, burning pain in the neck with dystonic deviation of the same backwards and dyskinesia. The mother reported that the child started vomiting and that three days before she had started therapy with metoclopramide 0.5 mg/kg/day IM following her paediatrician’s indication. In the suspicion of metoclopramide-induced extrapyramidal symptoms, blood chemistry tests were performed showing normal results and midazolam 0.2 mg/kg was administered leading to regression of symptoms. After twenty minutes symptoms recurred with pain-induced sinus tachycardia (HR 180 BPM). Therefore, she was administered a second dose of midazolam EV at 0.15 mg/kg that led to a complete and definitive regression of symptoms. Metoclopramide is a neuroleptic drug indicated only for the treatment of post-operative vomiting or chemotherapy in children over one year. The most common adverse reaction is the onset of extrapyramidal symptoms. A careful risk-benefit balance must always be performed before deciding whether to administer an antiemetic drug.
Una colestasi che ritorna
Authors: Medici Francesco
Published: October 2022

The case of a 13-month-old girl with recurrent cholestasis finally diagnosed with BRIC (Benign Recurrent Intrahepatic Cholestasis) is described. The clinical, therapeutic and prognostic implications of BRIC are also discussed.
Tubercolosi in età pediatrica: una diagnosi potenzialmente elusiva
Authors: Guida Gabriella , Garancini Nicolò , Rubinacci Valeria , Zuccotti Gianvincenzo , Giacomet Vania
Published: October 2022

The paper presents the case of Pakistani girl with low-grade fever, malaise and non-specific abdominal pain, finally diagnosed with pulmonary and extra-pulmonary TB.
Un calciatore con il mal di schiena
Authors: Lattuada Martina , Pagano Marta
Published: October 2022

The authors describe the case of a teenager with low back pain, abdominal pain and low-grade fever finally diagnosed with Crohn’s disease. The intestinal and extraintestinal manifestations of the disease are discussed.
Forord
Authors: Ursin Giske
Published: October 2022

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Gratulerer til en sprek 70-åring!
Authors: Kjerkol Ingvild
Published: October 2022

Kreftsaken vekker et sterkt engasjement hos mange av oss. Det berører oss som venner, pårørende eller som pasienter. Kreftregisteret har ivaretatt det store engasjementet for kreftsaken og omsatt det til innsats. Det er derfor med stor glede jeg hilser Kreftregisteret på 70-års dagen.
Krefttrender i Norge i perioden 1953–2021
Authors: Larsen Inger Kristin , Møller Bjørn , Ursin Giske , Robsahm Trude Eid
Published: October 2022

Prostatakreft ble den dominerende kreftformen tidlig på 1960-tallet, mens brystkreft har vært den vanligste kreftformen blant kvinner siden Kreftregisteret ble etablert. I 2021 utgjorde prostata-, bryst-, tarm- og lungekreft, nesten halvparten (47%) av alle nye krefttilfeller. Når vi ser på trender over tid, har de aller fleste kreftsykdommene hatt en økning i de aldersstandardiserte insidensratene. Siden 1950-tallet er lungekreft blant kvinner og hudkreftformene melanom og plateepitelkarsinom de kreftformene som har økt mest, mens magesekkreft er den eneste kreftformen som har hatt en jevn og stabil reduksjon i insidensen.
Hjerte- og karsykdom var lenge den vanligste dødsårsaken i Norge, men den aldersstandardiserte mortalitetsraten har gått ned siden 1970-tallet. Mortalitetsraten for kreft har sunket de siste 20 årene, men i mye mindre grad enn for hjerte- og karsykdom. Fra 2017 har kreft vært den sykdomsgruppen som har hatt høyest mortalitetsrate. Av spesifikke kreftformer hadde magesekk den høyeste mortalitetsraten (for begge kjønnene samlet) fram til 1970-tallet. Bryst- og prostatakreft lå høyest på 1970-, 80-, og 90-tallet. Fra 2000-tallet har lungekreft hatt den høyeste mortalitetsraten.
Overlevelsen har økt for alle kreftformer, og i dag overlever tre av fire sin kreftsykdom i 5 år eller mer. Kreftformer med dårlig langtidsprognose har hatt en betydelig forbedring i overlevelsen de siste 10–20 årene. En tallmessig økende befolkning og en høyere andel av eldre vil føre til et økt antall krefttilfeller i de kommende årene.
The role of pregnancy in maternal cancer risk: Epidemiologic evidence from the Nordic Countries Linked Birth and Cancer Registries Cohort Project
Authors: Troisi Rebecca , Glimelius Ingrid , Grotmol Tom , Gissler Mika , Kitahara Cari M. , Anne Gulbech Ording , Sæther Solbjørg Makalani Myrtveit , Camilla Sköld , Henrik Toft Sørensen , Trabert Britton , Bjørge Tone
Published: October 2022

Rebecca Troisi, Ingrid Glimelius, Tom Grotmol, Mika Gissler, Cari M. Kitahara, Anne Gulbech Ording, Solbjørg Makalani Myrtveit Sæther, Camilla Sköld, Henrik Toft Sørensen, Britton Trabert and Tone Bjørge: The role of pregnancy in maternal cancer risk: Epidemiologic evidence from the Nordic Countries Linked Birth and Cancer Registries Cohort Project
The Cancer Registry of Norway – “a ground for scientific harvesting”
Authors: Engeland Anders , Nystad Wenche , Selmer Randi
Published: October 2022

The Cancer Registry of Norway (CRN) has been important in registry-based research in Norway for decades. The use of CRN in combination with other population-based registries and health surveys have been the basis for numerous research projects, which has contributed to fill important knowledge gaps. Researchers at the Norwegian Institute of Public Health and CRN have a long tradition of using these data sources to address research questions of common interests such as e.g. the effect of life style and diet on cancer risk. CRN and the Medical Birth Registry of Norway have co-existed for a long period, making it possible to study cancer incidence and birth characteristics over generations. During the last decades, several new registries such as the Norwegian Prescription Database and the Norwegian Patient Registry have been established, providing opportunities for studying for example drug use and cancer risk and the influence of comorbidities on the development of cancer. In the future, the CRN will be an even more valuable data source when also other population-based registries and health surveys have existed for longer time periods.
Samle, telle, regne, fortolke – tilbakeblikk på Kreftregisterets statistikkproduksjon og forskning gjennom 70 år
Authors: Grimsrud Tom K.
Published: October 2022

The Cancer Registry of Norway was established 1952 with important initiatives and impetus from WHO and The Norwegian Cancer Society. The main purpose of the Registry has been to describe and explain trends and frequencies in cancer incidence, to analyse the need for cancer prevention and therapy, inclusive of aetiological research, and to study the effects of cancer control. The first report on cancer incidence covering 1953–1954 was published in 1959. In the 1950s, stomach cancer was the most common cancer among men and women combined, breast cancer was the most frequent cancer in women, and lung cancer was rising in men (observed in the mortality rates). Identification and the full understanding of different aspects of smoking and cancer remained a challenge from the 1950s through the 1980s, nationally and internationally. From 1977 to 1989, the Cancer Registry produced incidence reports every year with tables presenting absolute numbers and crude rates. In the 1990s, age-standardisation appeared in routine data, both in national, county, and historical rates. During the initial decades, important scientific support was received from Denmark, UK and the USA. Nordic co-operation has always been vital for exchange of experience, for comparisons, and for addressing rare cancer forms. Studies of occupational cancer emerged from the early 1970s, starting with nickel refiners and asbestos cement workers. The number of scientific publications and defended doctoral theses rose markedly during the 1990s and after, with projects directed towards aetiology (lifestyle, medication, occupation, environmental exposures), early diagnosis and screening, clinical issues, predictions, survival, biomarkers, and socio-economic factors.
Kreftregisteret – full fart fremover. Utviklingen de siste 10 år.
Authors: Ursin Giske
Published: October 2022

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Stoccolma per Marianne – Which innovation is worthy of patent protection in the era of incremental innovation?
Authors: Ghidini Gustavo
Published: October 2022

Long, long “gone are the days” of the XIX parameter of a ‘flash of genius’ to define the qualitative level of an innovation deserving of a patent. That parameter went out, as known, due to the evolution of modern R&D dynamics, chiefly consisting (unlike the groundbreaking ones of the first industrial revolution) in painstaking processes made up of progressive even small but quite costly steps carried on by trial and error (J. Reichman) by complex teams of specialist researchers, working with sophisticate computing and scientific equipment. No wonder, then, that a clear tendency emerged and became established in favor of lenient criteria of patentability, so as to include the fruits of incremental innovation.
EVOLUȚIA CONCEPTULUI DE RĂZBOI HIBRID ÎN STRATEGIILE NAȚIONALE DE APĂRARE ALE ROMÂNIEI
Authors: DUMITRU Ilie Răsvan
Published: October 2022

Dispariţia caracterului hegemonic bipolar, procesul de globalizare, prezervarea unor statute hegemonice și apariția unor agresiuni de tip hibrid, pe fondul concurențial tensionat al piețelor și resurselor au fost factorii fundamentali care au produs mutaţii majore în mediul de securitate internaţional, fapt ce a necesitat regândirea apărării naționale, pe baza noilor riscuri și amenințări la adresa statului. Modalitatea de concepere a strategiilor naționale de apărare și conţinutul acestora au variat de la o perioadă la alta, în funcţie de evenimentele internaționale, de crizele economice, de jocurile geopolitice, precum şi de afilierile trecute şi prezente la instituţii şi organizaţii regionale sau internaţionale. Conceptul de război hibrid a fost introdus etapizat în strategiile de apărare, inițial acesta fiind asociat cu unele tipare mai cunoscute, precum agresiuni asimetrice, informaționale, terorism sau atacuri cibernetice, urmând ca, pe măsura diluării granițelor dintre pace și război, acesta să fie mai bine nuanțat, dezvoltat și argumentat.
INFLUENȚA CULTURII ÎN POLITICA CHINEI. PERSPECTIVA CHINEZĂ ASUPRA INSTITUTELOR CONFUCIUS
Authors: VEREȘ Diana-Elena
Published: October 2022

În ultimele decenii, termenul soft power (putere blândă) devine, pe continentul asiatic, cel mai des utilizat termen străin și primește o atenție deosebită din partea atât a specialiștilor în relații internaționale, cât și a reprezentanților Partidului Comunist din China. Timp de aproape două decenii în care conceptul soft power a fost studiat și în care s-a încercat o adaptare a acestuia la valorile țării, China ajunge la concluzia că tradiția, cultura, istoria și filosofia țării pot reprezenta un avantaj în crearea unor legături atât cu țările din Asia, cât și cu cele din afara continentului asiatic. În acest sens, guvernul Chinei alocă o sumă generoasă de bani pentru înființarea centrelor de limbă, cultură și literatură chineză, numite „Institute Confucius”, în întreaga lume, pornind din Asia. În prezent, China susține că rolul acestora este unul deosebit de important, deoarece aceste centre, construite după modelul centrelor de limbă engleză, franceză, sau spaniolă, nu se adresează doar publicului doritor să învețe limba chineză, ci sunt un intermediar între China și țara-țintă, în scopul stabilirii unor relații de prietenie și de cooperare, prezentând cultura, istoria și civilizația chineză și atrăgând cât mai mulți simpatizanți spre China. Articolul prezintă, descrie și analizează structura și modul de operare a Institutelor Confucius, din perspectivă chineză, și ilustrează raportul dintre politica soft power a Chinei și programul de funcționare a acestora, așa cum este expus de sursele chineze în spațiul din afara țării.
ȘTEFAN FĂLCOIANU ȘI ȘCOALA SUPERIOARĂ DE RĂZBOI
Authors: HÎMPĂ Laura-Rodica
Published: October 2022

Acest articol are ca obiectiv prezentarea personalităţii lui Ştefan Fălcoianu (6 iunie 1835–22 ianuarie 1905) şi a vastei sale activităţi, cercetare fundamentată pe documentele inedite din Fondul Familial Fălcoianu de la Arhivele Naţionale ale României, din Bucureşti. Fondul documentar datează din anii 1836-1944 și a fost preluat de la Filiala Arhivelor Ilfov. Documentele conțin informații despre genealogia familiei Fălcoianu, date referitoare la activitatea generalului Ștefan Ioniță Fălcoianu. Corespondența păstrată reflectă legăturile lui Ștefan Fălcoianu cu personalități ale vremii: Constantin Barozzi1Octav George Lecca2, generalul belgian Henri Alexis Brialmont.
Utilização de planilha em Visual Basic Application – VBA para análise de dados de pavimentos urbanos
Authors: Alarcão Karoline Leão , Zanchetta Fábio , Viviani Eliane , Fernandes Júnior José Leomar
Published: October 2022

Um Sistema de Gerência de Pavimentos Urbanos (SGPU) visa manter as vias na melhor condição possível, ao menor custo. O objetivo geral dessa pesquisa foi desenvolver uma planilha em Visual Basic Application – VBA para o planejamento das atividades de Manutenção e Reabilitação - M&Rs segundo um determinado orçamento, a partir da hierarquização das vias pelo Índice de Prioridade - IP. Foram avaliados 150 segmentos de pista em 2019. Como resultados, foram definidas as M&Rs para cada segmento e sua respectiva área (m²) e custo (R$). As vias foram hierarquizadas e, assim, definidos os segmentos que receberiam a M&R naquele ano fiscal, de acordo com um orçamento disponível. Como conclusões, destacam-se que a utilização da linguagem VBA atende de forma satisfatória às demandas de organismos públicos municipais. A planilha VBA apresenta vantagens em termos de custos de aquisição quando comparado com outros softwares comerciais específicos para SGPU. Portanto, esta é uma ferramenta que pode ser implementada em todos municípios brasileiros a fim de melhorar a qualidade das decisões tomadas nas intervenções viárias.
Determinação de cafeína em bebidas, alimentos e medicamentos utilizando o smartphone e software para computador
Authors: Albino Sergio Marcio , Demuner Antonio Jacinto , Dos Santos Marcelo Henrique , Cerceau Cristiane Isaac , Blank Daiane , Castro Ciro
Published: October 2022

A cafeína é um alcaloide de ocorrência natural nas folhas e sementes de muitas plantas geralmente adicionadas a medicamentos, alimentos e produtos de bebidas, sendo uma das substâncias psicoativas mais consumidas no mundo. O consumo mundial per capita tem aumentado através do consumo de bebidas energéticas, medicamentos, chá verde, erva-mate e principalmente, do café. Brasil é líder mundial na produção e exportação de grãos de café. Desta forma, o presente estudo visa analisar e quantificar a presença de cafeína em amostras de café nos diferentes estágios de maturação, chá verde, erva-mate e medicamentos através da técnica de cromatografia em camada delgada (CCD). O smartphone foi utilizado para captura das manchas nas placas de CCD e o tratamento de imagens digitais foi feito a partir do uso de software computacional ImageJ. Os resultados das análises e quantificação foram comparados com os resultados no espectrofotômetro de UV-visível. Os resultados observados nos processos avaliativos foram satisfatórios o que valida a técnica simples e rápida para determinação de cafeína em amostras naturais e em formulações
Impacto da pandemia de COVID-19 no controle de doenças crônicas como diabetes, doenças da tireoide e câncer em Itumbiara-GO
Authors: Pereira Gondim Cecília Agnes , Ballco de Moraes Jonathan , Dos Santos Rodrigues Dantas Renata , Valverde Rodrigues Rodrigo Gabriel , Cokely Ribeiro Antônio Ricardo , Martins do Carmo João Paulo
Published: October 2022

Com a pandemia de COVID-19, o acompanhamento de doenças crônicas foi dificultado devido a ocupação dos hospitais por pacientes acometidos pela SARS-CoV-2, além da própria apreensão em se deslocar ara procurar atendimento. O objetivo do estudo foi avaliar a forma como a pandemia de COVID-19 impactou no acesso da população com doenças crônicas aos serviços de saúde na cidade de Itumbiara-GO. Este é um estudo transversal observacional descritivo. Foram analisados 2173 prontuários, considerando os parâmetros de idade e gênero, de pacientes que buscaram tratamentos médicos na Clínica São Lucas, 3 meses antes e 3 meses após o decreto que estabeleceu o lockdown da pandemia, no controle de doenças crônicas como diabetes mellitus, doenças da tireoide e câncer. O desencadear da pandemia de COVID-19 desestabilizou, por um curto período, o curso das consultas, voltando a normalidade. O retrato de pacientes continuou praticamente o mesmo em relação à idade e gênero, com predomínio de pessoas do sexo feminino comparecendo às consultas médicas, para tratamento preponderante de hipertireoidismo, enquanto a masculina buscou tratamento para diabetes mellitus tipo 2.
Treinamento de Biofeedback Cardíaco e Melhoria do Bem-Estar Subjetivo
Authors: Lopes Da Rocha Elizabeth de Fátima , Alves Wadson Luiz , Ballco de Moraes Jonathan , Galvão Filho Arlindo , Alves de Souza Letícia Cristina , Jubé Wastowski Isabela
Published: October 2022

O Gerenciamento do Estresse Psicossomático, baseado em técnicas de biofeedback psicofisiológico computacional, é um método moderno de treinamento e controle consciente do estresse. O biofeedback de Variabilidade da Frequência Cardíaca (VFC) é uma das estratégias mais confiáveis ​​para mensurar parâmetros relacionados ao funcionamento do sistema nervoso autônomo. O objetivo do estudo foi aplicar a técnica da VFC na avaliação e treinamento de universitários, correlacionando a coerência cardíaca às mudanças na percepção de bem-estar subjetivo (BES). Foram avaliados 82 alunos da Universidade Estadual de Goiás, Goiânia, Goiás, Brasil. A avaliação do biofeedback cardíaco e o treinamento foram realizados utilizando o software CardioEmotion (Neuropsicotronics, Universidade de São Paulo, SP). Para a realização deste estudo, foram medidas as VFCs dos alunos, em sessões consecutivas de treinamento, e comparadas as pontuações pré e pós-treinamento. Melhora significativa no BES foi demonstrada após o treinamento de biofeedback. A técnica também ajudou os participantes a aprender como restabelecer e manter a coerência cardíaca. Concluímos que o treinamento em VFC ajudou a reduzir os níveis de estresse e ansiedade relatados pelos participantes do estudo.
Incidência de Reações Transfusionais em hospitais do município de Itumbiara, Goiás
Authors: Ballco de Moraes Jonathan , Dias Leso Hugo , Moreira Kevin Silva , Gonçalves Araújo Erik Ricardo , Lopes Ricardo Augusto , Martins do Carmo João Paulo
Published: October 2022

Este trabalho teve como objetivo analisar a incidência de Reações Transfusionais em hospitais do município de Itumbiara-GO, discutir sobre as principais reações apresentadas e a necessidade de notificação para fins epidemiológicos. Foram analisados prontuários de 505 pacientes que necessitaram de transfusão no período de janeiro a dezembro de 2019, totalizando 1770 transfusões. O hemocomponente mais transfundido foi o Concentrado de Hemácias, seguido do Plasma Fresco Congelado, não havendo diferença estatística na incidência de transfusão quando comparados os pacientes por sexo (p=0,903). Os meses de férias escolares e meses com maior número de feriados nacionais apresentaram maior incidência de transfusões. Verificou-se alta taxa de reação em uma clínica de hemodiálise (p=0,002) e subnotificação em um hospital (p=0,006). Este estudo possibilitou maior conhecimento da realidade dos serviços de saúde de Itumbiara, bem como sugere um alerta para que aprimorem o sistema de hemovigilância em suas rotinas e passem a relatar com maior precisão e segurança as reações transfusionais, prevenindo futuras reações indesejáveis.
Predictive value of inflammatory indices: a prospective study in critical oncological patients
Authors: Pedrosa Aline Pereira , Martucci Renata Brum , Oliveira Livia Costa de , Do Amaral Paes Tatiana Cathoud , Peres Wilza Arantes Ferreira
Published: October 2022

The aim of this study was to evaluate the association of inflammatory indices and survival in critical cancer patients. This is a prospective, observational cohort study in which patients were followed up for 28 days after admission to the intensive care unit (ICU) of a reference hospital specialized in oncology. The neutrophil/lymphocyte ratio (NLR), monocyte/lymphocyte ratio (MLR), platelet/lymphocyte ratio (PLR), and modified Glasgow Prognostic Score (mGPS) were calculated within 24 hours of admission to the ICU. Spearman’s correlation, Kaplan-Meier survival curve, and Cox regression were used to associate the selected variables with survival. One hundred patients were selected, 78% of whom had active cancer, and 27 of whom died. Patients with mGPS 1 and 2 had a lower probability of 28-day survival and were 4.1 times more likely to die than the patients with mGPS 0. mGPS is a better predictor of survival than NLR, PLR, and MLR in critically ill patients diagnosed with solid tumors. Further studies are needed to establish the precise cutoff point for mGPS in relation to mortality and to assess its applicability in clinical practice.

Keywords: inflammation; critical care; neoplasms; prognosis.