bluuebunny/crossref_metadata_2025 huggingface dataset:
Designing of e-voting application for mosque youth leader election (case study in masjid Al-Ishlahiyah Gampong Lambhuk)
Authors: Husna Juniana , Fadhliadin M. Hindra , Basrul
Published: January 2024

[Bahasa]: Kegiatan pengabdian ini bertujuan untuk merancang sistem informasi pemilihan ketua remaja masjid di Gampong Lambhuk Banda Aceh. Perancangan dan pembuatan sistem ini mengimplementasikan model software development life cycle (SDLC). Model ini merupakan model pengembangan sistem yang paling sederhana. Salah satu model SDLC yang paling banyak diterapkan dan dapat dipahami dengan mudah adalah model waterfall. Metode pengembangan sistem ini mampu menyusun sistem dari bagian-bagian kecil. Model ini diawali dengan analisis kebutuhan dari sistem yang akan dirancang, desain sistem dan software, penerapan dan pengujian, serta evaluasi dan perbaikan sistem. Hasil testing melalui black-box test adalah tidak ditemukan adanya eror ketika aplikasi berbasis web ini dijalankan dan aplikasi ini berjalan dengan lancar. Pemungutan suara menggunakan e-voting ini dapat membantu menjangkau semua pemilih dan pemilih bisa menyampaikan suaranya tanpa harus hadir ke lokasi pemilihan. Implementasi sistem informasi pemilihan (e-voting) Remaja Mesjid ini juga dapat membantu pelaksanaan kegiatan pemilihan ketua remaja masjid berjalan efisien, cepat dan transparan.
Kata kunci: e-voting, sistem informasi, Metode SSDLC (System Development Life Cycle), waterfall
[English]: This study aims to design an information system to elect mosque youth leaders in Gampong Lambhuk Banda Aceh. The design and manufacture of this system implement the software development life cycle (SDLC) model. This model is the most straightforward system development model. The waterfall model is one of the most widely applied SDLC models and can be easily understood. This system development method can compile a system from small parts. This model begins with analyzing the system's needs, system and software design, implementation and testing, and system evaluation and improvement. The results of testing through black-box tests are that no errors are found when this web-based application is run, and this application runs smoothly. Voting using e-voting can help reach all voters, and voters can cast their votes without having to be present at the election location. Implementing e-voting can also help elect the mosque's youth chairperson. Furthermore, these activities run efficiently, quickly, and transparently.
Keywords: e-voting, information system, System Development Life Cycle, waterfall
Indigenous Islamic Multiculturalism: Interreligious Relations in Rural East Java, Indonesia
Authors: Umam Fawaizul , Barmawi Mohamad
Published: January 2024

This research-based article discusses interreligious relations and religious believers’ views as determining forms of interreligious relations. It chose a village in a rural area as the research locus, namely Sukoreno, Jember Regency, East Java Province. This village has four religious communities (Islam, Hinduism, Christianity, Catholicism) and one mysticism community (Sapta Darma). So far, they have displayed a peaceful-productive relationship amid the cultural diversities, especially religious differences. This is interesting in Indonesia's current situation, which is often plagued by religious conflicts. It is also important in the context of multiculturalism discourse, which tends to be urban-biased and its enrichment in an Islamic perspective. Therefore, this study explores forms of interreligious relations and how the Sukoreno community uses them as cultural energy to build social cohesion. From an Islamic perspective, the findings can be used as a pilot model for multicultural Indonesian society, both in rural areas and urban areas, where demographically, the majority of citizens are Muslims. Moreover, interreligious relations in Sukoreno can prove that Indonesian people have the cultural wealth to build their own multiculturalism, rooted in the cultural treasures of their own locality, indigenous Islamic multiculturalism.
Penemuan Kasus Tuberkulosis Pada ODHA di NTT : Integrasi Pendekatan Keluarga dan Dukungan Lokal
Authors: Manurung Imelda Februati Ester Manurung , Astutik Erni Astutik , Saputra Firman Firdauz Saputra , Wahyuni Chatarina Umbul Wahyuni
Published: January 2024

Buku monograf “Kasus Tuberkulosis Pada ODHA di NTT: Integrasi Pendekatan Keluarga dan Dukungan Lokal” ini disusun berdasarkan hasil penelitian pada ODHA di wilayah NTT, hasil FGD dengan pihak terkait dan menggunakan berbagai sumber rujukan, seperti program Pemerintah dan jurnal ilmiah serta yang ditelaah oleh praktisi dan akademisi. Buku ini dapat digunakan sebagai salah satu referensi dalam menghadapi penyakit Tuberkulosis. Selain itu buku ini juga dapat digunakan untuk membantu ODHA terkait penemuan kasus Tuberkulosis menggunakan metode pendekatan keluarga dan dukungan lokal sehingga dapat meningkatkan penemuan kasus Tuberkulosis pada ODHA.Pokok bahasan dalam monograf ini dimulai pada Bab 1 yang berisi tentang besaran masalah tuberkulosis (TB) dan HIV di Indonesia, selain itu pada bagian prolog juga berisi tentang masalah terkait sulitnya deteksi kasus TB pada ODHA serta di akhir bagian terdapat solusi untuk penemuan kasus TB pada ODHA di NTT. Pokok bahasan pada Bab 2 berisi materi yang memuat tentang kajian teoritis mengenai penemuan kasus tuberkulosis pada orang dengan HIV dan AIDS dengan integrasi pendekatan keluarga dan dukungan lokal di daerah terluar Provinsi Nusa Tenggara yang terdiri dari materi terkait tuberkulosis, dukungan lokal, health literacy, kepemimpinan melayani, pendekatan keluarga, dan dukungan lokal. Pokok bahasan pada Bab 3, Bab 4, dan Bab 5 karakteristik ODHA, keluarga, dan dukungan lokal serta penyusunan model integrasi pendekatan keluarga, dan pendekatan lokal. Di akhir buku, terdapat epilog berisi simpulan dari hasil temuan penulis yang dapat digunakan untuk mencegah hal tersebut terjadi. Buku ini diharapkan dapat menjadi acuan bagi para ODHA untuk mengurangi perilaku berisiko penularan tuberkulosis sehingga dapat mengurangi masalah HIV/AIDS sehingga kualitas hidup dapat meningkat. Selain itu, buku ini dapat digunakan oleh tenaga kesehatan utamanya bagi perawat dalam penemuan tersangka kasus tuberkulosis pada ODHA.
Harnessing genetically engineered cell membrane-derived vesicles as biotherapeutics
Authors: Li Xiaohong , Wei Yuting , Zhang Zhirang , Zhang Xudong
Published: January 2024

Cell membrane-derived vesicles (CMVs) are particles generated from living cells, including extracellular vesicles (EVs) and artificial extracellular vesicles (aEVs) prepared from cell membranes. CMVs possess considerable potential in drug delivery, regenerative medicine, immunomodulation, disease diagnosis, etc . owing to their stable lipid bilayer structure, favorable biocompatibility, and low toxicity. Although the majority of CMVs inherit certain attributes from the original cells, it is still difficult to execute distinct therapeutic functions, such as organ targeting, signal regulation, and exogenous biotherapeutic supplementation. Hence, engineering CMVs by genetic engineering, chemical modification, and hybridization is a promising way to endow CMVs with specific functions and open up novel vistas for applications. In particular, there is a growing interest in genetically engineered CMVs harnessed to exhibit biotherapeutics. Herein, we outline the preparation strategies and their characteristics for purifying CMVs. Additionally, we review the advances of genetically engineered CMVs utilized to target organs, regulate signal transduction, and deliver biomacromolecules and chemical drugs. Furthermore, we also summarize the emerging therapeutic applications of genetically engineered CMVs in addressing tumors, diabetes, systemic lupus erythematosus, and cardiovascular diseases.
A review of mechanical properties and carbonation behavior evolution of lime mortar for architectural heritages restoration
Authors: Chen Zhenmeng , Liu Hui , Xu Lingjie , Ge Wei
Published: January 2024

Using lime mortar to connect, protect and decorate buildings was a very common technique in ancient times. Understanding the mechanical properties and carbonation mechanism of lime mortar is the basis for successful restoration and protection of architectural heritage. The compatibility and durability of lime mortar and architectural heritage promote the study of related mechanisms, so that it can adapt to the current reality. In this paper, the factors affecting the mechanical properties of lime mortar are summarized, and the carbonization principle of lime mortar is analyzed. The effects of water-binder ratio, aggregate mineralogy and particle size, inorganic additives and organic additives on the mechanical properties of lime mortar were elaborated in detail, especially the action behavior of organic additives in the carbonation process of lime mortar. Suggestions for enhancing the mechanical properties of lime mortar are put forward, which provides a theoretical basis for improving the compatibility and durability of materials in the restoration of ancient buildings.
Tidak Kompeten! Bagaimana Laki-Laki Memandang Perempuan dalam Game Online Valorant?
Authors: Putra Sudiana Nyoman Agil , Sari Ratna Permata
Published: January 2024

Online games are an activity that male players dominate. However, Valorant is a game that is also popular with female players. This often gives rise to stereotypes among men. This research investigates female stereotypes in the online game Valorant. This research uses virtual ethnographic methods. Data collection was carried out using participant observation and in-depth interviews. Gender stereotypes believed by male players in the online game Valorant are assessed from cognitive, affective, and conative aspects. This research found that female gender stereotypes, from a cognitive aspect, are incompetent in playing, do not accept input, and have good teamwork. From the affective aspect, female players are identified as being sensitive, easily irritated, lacking confidence in their playing performance, communicating aggressively, and often saying rude things. From the conative aspect, male players always take action to ensure that female players are protected and led, tend to choose agents with a supporting role, are not competitive, and are passive in communicating.
Wireless Power and Data Transfer via mm-Wave Simultaneously Using Beamforming Technology through 5G Small Towers
Authors: Juna Ghulam , Pires Ivan Miguel , Coelho Paulo Jorge , Leithardt Valderi Reis Quietinho , González Gabriel Villarrubia , Butt Pinial Khan
Published: January 2024

The world is heading toward significant advancements in science and technology, particularly in wireless communication technology, to improve and modify how wireless communication functions before introducing the new 5G technology. This new 5G spectrum will allow wireless networks to communicate at this level. Because of the low latency rate provided by 5G, this experiment utilized the E-band, also known as mm-wave transmissions, which can alter how network device manufacturers think. Wireless communication systems can help to improve device-to-device communication performance. The customer benefits from complete 5G service and extremely high network data transfer rates. In the tests and results, resolving some open problems related to speeds and data transfer rates was possible. Therefore, we believe the contributions are significant and can improve systems and users.
Polyelectrolyte Platforms with Copper Nanoparticles as a Multifunctional System Aimed at Healing Process Support
Authors: Lipko Agata , Grzeczkowicz Anna , Antosiak-Iwańska Magdalena , Strawski Marcin , Drabik Monika , Kwiatkowska Angelika , Godlewska Ewa , Granicka Ludomira H.
Published: January 2024

Purpose: The aim of the study is an approach to a nanocomposite with copper nanoparticles, constituting a bacteriostatic surface for maintaining the human lung cells' function. Methods: The polyelectrolyte layer coating with copper nanoparticles incorporated was designed. As a bacteriostatic factor, copper nanoparticles were applied as a colloidal solution of copper nanoparticles (ColloidCuNPs) and solution of copper nanoparticles (CuNPs). The influence of polyelectrolytes on selected Gram(+) and Gram(-) strains was examined. The function of the human adenocarcinoma A549 cell line of epithelial human lung cells cultured in the presence of nanocomposite layer coatings was analyzed, as well as their morphology using flow cytometry, fluorescence microscopy, and scanning electron microscopy. In addition, the material of layer coating was assessed using AFM and SEM-EDX characterization. Results: It was observed that polyelectrolytes polyethylenimine and poly-L-lysine do not induce proliferation of E.coli strain. On the other hand, it induces the proliferation of S. aureus strain. Due to CuNPs effectiveness against E.coli strain, CuNPs were selected for further research. The designed coatings at proper NPs share sustained the function of human lung cells cultured within 10 days of culture. The AFM and EDX characterization confirmed copper presence in the layer coating nanomaterial. The presence of CuNPs in polyethyleneimine-based nanocomposite deepens the bacteriostatic effect on E. coli compared with PEI alone. Meanwhile, incorporating CuNPs in PLL at share allowed A549 cell maintenance, did not exert a bacteriostatic influence on the examined strain.Conclusion: The platform based on polyelectrolytes incorporated with copper nanoparticles ensuring the growth and morphology of the human lung epithelial cells can be considered an element of the system components for medical devices for maintaining the human lung cells' function.
A Quantitative Comparison of Mortality Models with Jumps: Pre- and Post-COVID Insights on Insurance Pricing
Authors: Şahin Şule , Özen Selin
Published: January 2024

Population events such as natural disasters, pandemics, extreme weather, and wars might cause jumps that have an immediate impact on mortality rates. The recent COVID-19 pandemic has demonstrated that these events should not be treated as nonrepetitive exogenous interventions. Therefore, mortality models incorporating jump effects are particularly important to capture the adverse mortality shocks. The mortality models with jumps, proposed by Cox. et al. , Chen and Cox , and Özen and Şahin , which we consider in this study, differ in terms of the duration of the jumps - transitory or permanent, frequency of the jumps, and size of the jumps. To illustrate the effect of jumps, we also consider benchmark mortality models without jump effects, such as the Lee-Carter , Renshaw and Haberman and the Cairns-Blake-Dowd models. We discuss the performance of all the models by analysing their ability to capture the mortality deterioration caused by COVID-19. We use data from different countries to simulate the mortality rates for the pandemic years and examine their accuracy in forecasting the mortality jumps due to the pandemic. Moreover, we also analyse the impact of mortality jump models on catastrophe bond pricing.
Effects of Two Online Mindfulness Based Interventions for Early Adolescents over Attentional, Emotional and Behavioral Self-Regulation
Authors: Porter Bárbara , Oyanadel Cristian , Betancourt-Peters Ignacio , Peñate Wenceslao
Published: January 2024

(1) Background: Mindfulness-based interventions (MBIs) have shown interesting preliminary ef-fects over self-regulation processes in early adolescence. However, interventions usually integrate various types of practices with no clarity about the specific effect of each of them over attentional, emotional, and behavioral regulation. The objective of this research was to evaluate the effect of two MBIs, one focused on classic attentional practices and another one focused on the recognition and expression of emotions, over attentional, emotional, and behavioral self-regulation in early adolescents. (2) Method: An experimental method was carried out. A sample of 70 children be-tween 8 and 12 years old were randomized and assigned to three experimental conditions: 1) MBI with a focus on attentional practices, 2) MBI with a focus on recognition and expression of emotions, 3) control group, waiting list. The programs lasted 8 weeks, with a weekly 1-hour online synchronic session, plus home practices. Children were evaluated before starting the in-tervention and at the end of the 8-week program. The assessed variables were: 1) Mindfulness; 2) Emotional Regulation; 3) Attentional Regulation and 4) Behavioral regulation. (3) Results: Chil-dren that participated in both programs, increased their mindfulness and emotional and be-havioral regulation scores. Only children who participated in the program with a focus on at-tention showed significant changes in their ability to self-regulate attention. (4) Conclusions: online MBIs, with attention to external and internal stimuli practices, can be a good strategy to strengthen self-regulation skills of attention, emotions, and behavior in early adolescence.
Characterization of PDGF-Induced Subcellular Calcium Regulations through Calcium Channels in Airway Smooth Muscle Cells by FRET Biosensors
Authors: Ouyang Mingxing , Zhou Binqian , Feng Jiayue , Zhang Qingyu , Li Chunmei , Deng Linhong
Published: January 2024

The homeostasis of cellular calcium is fundamental for many physiological activities, while calcium levels maintain inhomogeneous within cells. During the onset of asthma, epithelial and inflammatory cells secrete platelet derived growth factor (PDGF), inducing proliferation and migration of airway smooth muscle (ASM) to the epidermal layer, narrowing the airway. The regulation of ASM cells by PDGF is closely related to the conduction of calcium signals. In this work, we generated subcellular-targeted FRET biosensors to investigate calcium regulations at different compartments of ASM cells. PDGF-induced cytoplasmic calcium [Ca2+]C increase was attributed from both extracellular calcium influx and endoplasmic reticulum (ER) calcium [Ca2+]ER release, which was partially regulated by PLC-IP3R pathway. Interestingly, removal of extracellular calcium influx led to inhibited ER calcium release, likely through inhibitory effect on calcium-dependent activation of ER ryanodine receptor. Inhibition of L-type calcium channel on plasma membrane, or SERCA pump on ER resulted in both reduced [Ca2+]C and [Ca2+]ER from PDGF stimulation, while IP3R channel inhibition led to reduced [Ca2+]C only. Inhibited SERCA pump caused immediate [Ca2+]C increase and [Ca2+]ER decrease, indicating an active calcium exchange between cytosol and ER storage in resting cells. PDGF-induced calcium at outer mitochondrial membrane sub-region showed similar regulatory response to cytosolic calcium, not influenced by inhibition of mitochondrial calcium uniporter channel. Therefore, our work identified calcium flow pathways among extracellular medium, cell cytosol, and ER by regulatory calcium channels. Particularly, extracellular calcium flow has an essential function to fully activate ER calcium release.
Understanding and Modeling the Pathophysiology of Hydrocephalus: In Search of Better Treatment Options
Authors: Newland Verayna , Blazer-Yost Bonnie L.
Published: January 2024

Hydrocephalus is caused by an overproduction of cerebrospinal fluid (CSF), a blockage of fluid circulation, or improper reabsorption. CSF accumulation in the brain’s ventricles causes ventriculomegaly and brain cell damage. Hydrocephalus can be caused by brain trauma, hemorrhage, infection, tumors, or genetic mutations. Currently, there is no cure for hydrocephalus. Treatments like shunting and endoscopic third ventriculostomies are used, but unfortunately, these techniques require brain surgery and have high failure rates. To advance the development of hydrocephalus treatments, physiologically relevant pre-clinical models are crucial. This review covers some of the current animal and cell culture methods used to study hydrocephalus. The choroid plexus epithelium (CPe) is thought to be the major producer of CSF in the brain. It is a polarized epithelium that regulates ion and water movement from a fenestrated capillary exudate to the ventricles. Despite decades of research, control of electrolyte movement in the CPe is still not fully understood. This review discusses important transporters on the CPe and how some of these could be potential targets for hydrocephalus treatment.
Principles for Adapting Assessments of Executive Function Across Cultural Contexts
Authors: Jukes Matthew C. H. , Ahmed Ishita , Baker Sara , Draper Catherine E. , Howard Steven J. , McCoy Dana Charles , Obradović Jelena , Wolf Sharon
Published: January 2024

Direct assessments of executive function (EF) are increasingly used in research and clinical settings, with a central assumption that they assess “universal” underlying skills. Their use is spreading globally, raising questions about the cultural appropriateness of assessments devised in Western, industrialized countries. We reviewed multidisciplinary evidence and theory to identify sets of cultural preferences that may be at odds with the implicit assumptions of EF assessments. These preferences relate to motivation and compliance; cultural expectations for interpersonal engagement; contextualized vs. academic thinking; cultural notions of speed and time; the willingness to be silly, be incorrect, or do the opposite; and subject-matter familiarity. In each case, we discuss how the cultural preference may be incompatible with the assumptions of assessments, and how future research and practice can address the issue. Many of the cultural preferences discussed differ between interdependent and independent cultures and between schooled and unschooled populations. Adapting testing protocols to these cultural preferences in different contexts will be important for expanding our scientific understanding of EF from the narrow slice of the human population that has participated in the research to date.
The Role of Ladder Training in Enhancing Athletic Performance: A Focus on Explosive Power and Speed in Adolescent Students
Authors: Ravi Pramod , Kalimuthu Divya
Published: January 2024

This research delved into exploring the impact of ladder training on improving the athletic performance of adolescent students, particularly focusing on boosting explosive power and speed. The study involved thirty boys aged 15-17, selected randomly from an Indian school in Doha, Qatar. The variables measured were Explosive Power (EP) and speed (S). EP was assessed using the Standing Broad Jump (SBJ), while Speed (S) was gauged through the 50-yard dash. Divided into two groups - the Experimental Group (EG) and the Control Group (CG), each consisting of fifteen students - the EG underwent dedicated ladder training for 12 weeks while the CG continued their routine. Analysis of pre-test and post-test results indicated significant enhancements in EP and speed within the EG, with notable shifts from 2.15±.27 to 2.40±.24and 7.52±.54to 6.97±.66, respectively, exhibiting significant 't' values (EP: -2.39; speed: 2.23) at P˂.05. Conversely, the CG showed minimal changes in EP (pre: 2.22±.22; post: 2.2±.21) and speed (pre: 7.51±.43; post: 7.58±.72), with 't' values of 0.295 and 0.842, respectively, failing to reach significance at P˂.05. These outcomes highlight the efficacy of ladder training in improving explosive power and speed among adolescent students, suggesting its potential as a safe and advantageous component in athletic training programs.
A Geometrical Study about the Biparametric Family of Anomalies in the Elliptic Two Body Problem with Extensions to Other Families
Authors: López Ortí José Antonio , Marco Castillo Francisco José , Martínez Usó María José
Published: January 2024

In the present paper, we efficiently solve the two-body problem for extreme cases such as those with high eccentricities. The use of numerical methods, with the usual variables, cannot maintain the perihelion passage accurately. In previous articles, we have verified that this problem is treated more adequately through temporal reparametrizations related to the mean anomaly through the partition function. The biparametric family of anomalies, with an appropriate partition function, allows a systematic study of these transformations. In the present work, we consider the elliptical orbit as a meridian section of the ellipsoid of revolution, and the partition function depends on two variables raised to specific parameters. One of the variables is the mean radius of the ellipsoid at the secondary, and the other is the distance to the primary. One parameter regulates the concentration of points in the apoapsis region, and the other produces a symmetrical displacement between the polar and equatorial regions. The three most used geodesy latitude variables are also studied, resulting in one not belonging to the biparametric family. However, it is in the one introduced now, which implies an extension of the biparametric method. The results obtained by the method presented here now allow a causal interpretation of the operation of numerous reparametrizations used in the study of orbital motion.
Skeletal Muscle Echo Intensity Values Differ across Ultrasound Dynamic Range Settings
Authors: Scafoglieri Aldo , Van den Broeck Jona , Bartocci Paolo , Cattrysse Erik , Jager-Wittenaar Harriët , Gonzalez Maria Cristina
Published: January 2024

Background: According to EWGSOP2, the diagnosis of sarcopenia is confirmed when in addition to low muscle strength, low muscle quantity or quality is present. Echo intensity (EI) determined by muscle ultrasound (US) has been proposed as an efficient method for the assessment of muscle quality. The effect of changing various US parameter settings on EI remains unclear. Therefore, the aim of this study was to assess the differences between EI values obtained by adjusting parameter settings over their entire range in a sample of middle-aged healthy subjects.
Methods: Thirty-two repeated US scans of rectus femoris (RF) and rectus abdominis (RA) muscles were taken in eight men and three women with a portable Mindray M7 premium US machine, working in an Extended field-of-view, B-Mode setup, equipped with a linear 5.0-10.0 MHz transducer. The following US parameters and settings were fixed: gain 60dB, depth 6.5cm, and frequency 10 MHz. Readily adjustable parameters were dynamic range (DR), gray map (GM), line density, persistence, and IClear. A default setting DR65 was chosen as the reference setting. For each of the parameters, the settings of one single parameter of interest was changed over its entire range following a standardized protocol. The EI values were calculated using the open-source software ImageJ. Repeated measures analyses were performed to evaluate the effect of parameter settings on EI. Linear interpolation was used to determine non-significant ranges across a given parameter.
Results: For the RF muscle, the EI values were significantly different across DR (p<0.001), GM (p<0.001), and IClear (p<0.001). Post hoc analysis confirmed the differences within these three settings. Echo intensity values within the range of DR55 to DR80 were not significantly different. For the RA muscle, the EI values were significantly different across DR (p=0.004) and GM (p=0.030). Post hoc pairwise comparisons revealed no significant difference with the default setting, except for DR150 (p=0.042).
Conclusion: We showed that EI values differ across the DR and GM range, especially in the RF. We suggest using a DR setting within its midrange to minimize the effect of machine setting-dependent factors on EI values. These findings reconfirm the need for standardization of ultrasound echo intensity settings when applied for diagnostic purposes of muscle quality.
Using XRF to Analyze Metals in Felled Trees on a Suburban New York College Campus
Authors: Nadler David
Published: January 2024

A field sampling event was conducted to measure the concentrations of metals within the trunks of felled trees on a college campus east of New York City. Heavy metals, particularly chromium, were found present in the soils surrounding the sampled trees, allowing for a correlation coefficient to be calculated with soil and tree concentrations. A statistically significant Pearson correlation was found between these two concentrations among the samples. This study is aimed at providing researchers a starting point for their research a better understanding of local ecologies, prediction of future change, and dissemination of conservation efforts.
Influence of the COVID-19 Pandemic on the Treatment of immune mediated Rheumatic and Musculoskeletal Diseases during the first pandemic period: A Systematic Review
Authors: Schlegel Marco , Bachmann Stefan
Published: January 2024

Background and Objectives: The COVID-19 pandemic influenced the management of patients with immune mediated rheumatic and musculoskeletal diseases (imRMDs) in various ways. The goal of our systematic review was to determine the influence of the first period of the COVID-19 pandemic on the management of imRMDs.
Materials and Methods: Systematic literature search of PubMed, Cochrane and Embase databases, including studies with adult patients on the influence of the COVID-19 pandemic on management of imRMDs. There were no restrictions regarding to study-design except for systematic reviews and case reports that were excluded as well as articles on the disease outcomes in case of SARS-CoV-2 infection. Two reviewers screened the studies for inclusion, and, in case of disagreement, consensus was reached after discussion.
Results: A total of 5969 potentially relevant studies were found, and, after title, abstract and full-text screening, 35 studies were included with data from 182’746 patients and 2018 rheumatologists. Non-availability of drugs, e.g., hydroxychloroquine and tocilizuab, was frequent (16–69% of patients). Further, medication non-adherence was reported among patients with different RMDs and between different drugs in 4–46% of patients. Changes to preexisting medication were reported in up to 33% of patients (e.g. reducing dose of steroids or cessation of biological disease-modifying antirheumatic drugs). Physical in-office consultations and laboratory testing decreased and as a consequence newly implemented remote consultations increased greatly with an increase of up to 80%.
Conclusion: The COVID-19 pandemic influenced the management of imRMDs, especially at the beginning. Influences were wide-ranging, affecting availability of pharmacies, adherence to medication or medication changes, doctor visits and laboratory testing. New systems of care were set up, including virtual clinics and video consultations. These new forms of health care delivery should be spread and implemented worldwide to routine clinical practice to be ready for future pandemics.
Role of Matrix Metalloproteinases in Thoracic Aortic disease: Are they indicators for the pathogenesis of dissections?
Authors: Irqsusi Marc , Dong Lan Anh , Rodepeter Fiora , Ramzan Rabia , Talipov Ildar , Ghazy Tamer , Günther Madeline , Vogt Sebastian , Rastan Ardawan Julian
Published: January 2024

Pathogenesis of aortic aneurysm and dissection continues to be under discussion. Extracellular matrix (ECM) remodeling processes in the aortic wall are hypothesized to be involved in the development of the disorders. Therefore, in a histological study, we investigated the expression of metalloproteases 1 and 9 (MMP1 and MMP9) and their inhibitors (TIMP 1 and TIMP 2) in cardiac surgery patients. In parallel, we studied the aortic roots by echocardiography. Clinical reports of 111 patients (30 women and 81 men) who suffered from aortic aneurysms and an aortic dissection were evaluated and studied by transesophageal echocardiography. Seven patients, who had coronary heart disease served as „healthy controls“ All patients were surgically operated in the period from 2007 to 2015. A tissue sample of the aortic biopsies was collected from each patient during surgery. Immunohistochemical staining was performed for MMP1, MMP9 and TIMP1, TIMP2 as well. Vascularization was monitored by an CD 31 antibody. In direct comparison, the expressions are not homogeneous. We found smallest changes in the intima area at all. An increase in MMP 1 and MMP 9 expression was detected in both media and adventitia in case of dissections. TIMP 1 and TIMP 2 distribution increases from the lumen of the vessel outward in the wall layers of the aorta. In case of arteriosclerotic changes, intima had a capillarization, but not in the media. Opposite pattern was found in the dissected aortas. Whereas the intima appears empty, vascularization was found in the media and adventitia layers, as well. There are differences in the vascularization between between the aneurysm and dissection and the different layers as well, respectively. A different remodeling process of the ECM in comparison of the vascular layers must be hypothesized. Reading the patterns of staining and with regard to the known inhibitory effect of MMP9 on ECM remodeling, but especially TIMP 2 on neoangiogenesis, a disturbed nutrition and a dysfunctional vasa vasorum remodeling must be assumed as cause of dissection.
A Method for Correcting Signal Aberrations in Ultrasonic Indoor Positioning
Authors: Carotenuto Riccardo , Iero Demetrio , Merenda Massimo
Published: January 2024

The increasing focus on the development of positioning techniques reflects the growing interest in applications and services based on indoor positioning. Many applications necessitate precise indoor positioning or tracking of individuals and assets, leading to rapid growth in products based on these technologies in certain market sectors. Ultrasonic systems have already proven effective in achieving the desired positioning accuracy and refresh rates. The typical signal used in ultrasonic positioning systems for estimating the range between the target and reference points, specifically the linear chirp, can undergo shape aberration due to the effects of acoustic diffraction when the aperture exceeds a certain limit. The extent of the aberration is influenced by the shape and size of the transducer, as well as the angle at which the transducer is observed by the receiver. This aberration also impacts the shape of the cross-correlation, causing it to lose its characteristic easily detectable single global peak. In such instances, cross-correlation techniques yield results with a significantly higher error than anticipated. In this study, an alternative technique to global peak detection is proposed, leveraging the inherent symmetry observed in the shape of the aberrated cross-correlation. The numerical simulations, performed using the academic acoustic simulation software Field II, conducted using a typical ultrasonic chirp and ultrasonic emitter, compare the classical and the proposed range techniques in a standard office room. The results demonstrate that the proposed technique enables accurate range estimation even in the presence of severe cross-correlation shape aberrations. This allows the use of emitting transducers with a much larger aperture than that allowed by the classical cross-correlation technique. Consequently, it becomes possible to have greater acoustic power available, leading to improved Signal-to-Noise Ratio (SNR).
Climate Change Impact on Management Practices of Maize Yield: Case of Mount Makulu, Zambia
Authors: Chisanga Charles Bwalya , Chilambwe Alice , Kipkulei Harison . K , Mubanga Kabwe H.
Published: January 2024

Abstract: Long-term rainfall, temperature and solar radiation time series data are required to simulate crop yield and yield variability. A field experiment conducted at Mount Makulu was used to simulate the interactive effect of planting dates (SD1, SD2, SD3), maize varieties (PIO30G19, PIO30B50, ZMS606), and nitrogen fertilizer application levels (N1 = 66; N2 = 132; N3 = 198 kg N ha-1) on strategic and economic assessment. Statistical downscaled climate datasets from three GCMs from 1971-2000, 2010-2039, 2040-2069, and 2070-2099 using Representative Concentration Pathways (RCP4.5, RCP8.5) were utilized as DSSAT v4.7 inputs. The Seasonal analysis Program of the DSSAT model was used to simulate the impacts of climate change on maize yield. Results show increasing trends in temperature while there is variability in rainfall. The biophysical analysis showed varied grain yield responses to sowing date, maize cultivars and N application rates. The Mean-Gini analysis showed that PIO30B50 had an efficient late sowing data (SD3) with an application of 132 and 168 kg N ha-1 under both scenarios. Further, PIO30G19 at SD3 with 198 kg N ha-1 would be the most dominant management option for maize grain yield under future climate scenarios from 2010-2099. This research emphasizes the urgency for tailored adaptation actions and collaborative efforts along the maize value chain to mitigate future yield losses and sustain food security. Increasing maize grain yield requires implementing adaptation strategies such as varying sowing dates, adopting late-maturing varieties with high thermal heat requirements under future climate scenarios.
New Approaches in Visceral Leishmaniasis Prevention: A Review of Recent Patents of Potential Candidates for a Chimeric Protein Vaccine
Authors: Oliveira Diana Souza de , Zaldívar Maykelin Fuentes , Gonçalves Ana Alice Maia , Resende Lucilene Aparecida , Mariano Reysla Maria da Silveira , Pereira Diogo Fonseca Soares , Santos Ingrid Soares , Costa Mariana Amália Figueiredo , Lair Daniel Ferreira , Vilas-Boas Diego Fernandes , Nakasone Eiji Nakasone , Ameno Ingrid de Sousa , Goes Wanessa Moreira , Silveira-Lemos Denise da , Galdino Alexsandro Sobreira , Nagem Ronaldo Alves Pinto , Dutra Walderez Ornelas , Giunchetti Rodolfo Cordeiro
Published: January 2024

Prophylactic vaccines are important in the control of visceral leishmaniasis (VL) and as economic measures for public health. Despite the efforts to develop a vaccine against human VL caused by Leishmania infantum, none is available, and the focus has shifted to developing vaccines against canine visceral leishmaniasis (CVL). Currently, commercially available vaccines are targeted at CVL but are not effective. Different strategies have been applied in developing and improving vaccines, such as using chimeric proteins to expand vaccine coverage. The search for patents can be a way of tracking vaccines that have the potential to be marketed. In this context, the present work presents a summary of immunological aspects relevant to VL vaccine development with a focus on the composition of chimeric protein vaccines for CVL deposited in patent banks as an important approach for biotechnological development. The resulting data could facilitate the screening and selection of antigens to compose vaccine candidates with high performance against VL.
Negevirus Piura Suppresses Zika Virus Replication in Mosquito Cells
Authors: Carvalho Valéria Lima , Prakoso Dhani , Schwarz Erika R. , Logan Tracey D. , Nunes Bruno Tardelli Diniz , Beachboard Sarah E. , Long Maureen T.
Published: January 2024

We investigated the interaction between the insect-specific virus, Piura virus (PIUV) and the arbovirus Zika virus (ZIKV) in Aedes albopictus cells. We performed coinfection experiments in C6/36 cells. Piura virus (Cor 33 strain, Colombia) and ZIKV (PRVABC58 strain, Puerto Rico) were co-inoculated into C6/36 cells using two MOI combinations: 0.1 for both viruses and 1.0 for ZIKV, 0.1 for PIUV. Wells were infected in triplicate with either PIUV and ZIKV coinfection, ZIKV-only, or PIUV-only. Mock infected cells served as control wells. The cell suspension was collected daily through 7 days post-infection. Zika virus load was titrated by TCID50 on Vero 76 cells. The ZIKV-only infection and PIUV and ZIKV coinfection experiments were also quantified by RT-qPCR. We also investigated whether ZIKV interfered in the PIUV replication. PIUV suppressed the replication of ZIKV resulting in a 10,000-fold reduction in ZIKV titers within 3 days post-infection. PIUV viral loads were not reduced in the presence of ZIKV. We conclude that, when concurrently infected, PIUV suppresses ZIKV in C6/36 cells while ZIKV does not interfere in PIUV replication.
Pd:In-Doped TiO2 as a Bifunctional Catalyst for the Photoelectrochemical Oxidation of Paracetamol and Simultaneous Green Hydrogen Production
Authors: SACCO NICOLÁS , IGUINI ALEXANDER , Gamba Ilaria , Marchesini Fernanda Albana , GARCÍA GONZALO
Published: January 2024

The integration of clean energy generation with wastewater treatment holds promise for addressing both environmental and energy concerns. Focusing on photocatalytic hydrogen production and wastewater treatment, the study introduces PdIn/TiO2 catalysts for the simultaneous removal of the pharmaceutical contaminant paracetamol and hydrogen production. Physicochemical characterization showed a high distribution of Pd and In on the support as well as a high interaction with it. The Pd and In deposition enhances the light absorption capability and significantly improved HER in comparison to TiO2 not only in the electrolyte but also in presence of paracetamol. Regarding PTM oxidation, TiO2 and PdIn/TiO2 showed an irreversible behavior toward the PTM oxidation, limited by the adsorption of species on the electrode surface. Thus, PdIn-doped TiO2 stands out as a promising catalyst, showcasing enhanced physicochemical properties and superior catalytic performance. This underscores its potential for both environmental remediation and sustainable hydrogen production.
Bioethanol Revolution: Unveiling the Advancement and Emerging Trends in Production of Sustainable Energy Production
Authors: Okechukwu Ezike Ngozika Chinonyerem , Johnson Nnadikwe , Ahmed Chandio, Zubair , Enobong Okure Unyime
Published: January 2024

AbstractWelcome to the world of bioethanol revolution, in response to the soaring global energy demand, the production of bioethanol has taken center stage, captivating the attention of governments, academia, and the private sector alike. Over the years, research in this field has witnessed exponential growth, paving the way for sustainable energy production. Ethanol, the front-runner in renewable energy, can be derived from a plethora of sources. In this abstract, we will explore the exciting advancements and emerging trends in the production of bioethanol, shedding light on the promising future of sustainable energy. Bioethanol production presents a cost-effective solution by utilizing the abundance of agricultural resources. These resources serve as the foundation for producing bioethanol from various biomass sources. In this context, we evaluate the raw materials used, including sucrose-based, starchy-based, and perennial grasses. By exploring these options, we can gain a comprehensive understanding of the diverse range of agricultural feedstocks that contribute to the production of bioethanol, this paper delves into the multiple processes involved in the production of bioethanol from agricultural base biomass, unveiling a range of possibilities for harnessing renewable energy. The key steps that were thoroughly examined include pretreatment, which encompasses both physical and chemical methods, hydrolysis, direct fermentation, and saccharification. These steps serve as crucial components in the overall bioethanol production process from agricultural base biomass. By understanding and optimizing each of these stages, we can unlock the full potential of sustainable energy generation. The paper goes beyond exploring the production processes and delves into the different generations of bioethanol, each with its unique components. Additionally, it provides a comprehensive overview of the composition of agricultural and forest residues, shedding light on their potential as valuable resources for bioethanol production. Moreover, it highlights the significance of the agricultural sector in Nigeria's economy, emphasizing the importance of energy for enhancing productivity and efficiency. The integration of bioethanol as an energy source has the potential to propel this sector forward, fostering sustainable development and contributing to the overall growth of the Nigerian economy. By harnessing the power of bioethanol, Nigeria can tap into its energy potential, promoting energy utilization and creating a positive impact on various industries.
How Disaster Prevention Videos Contribute to Tsunami Evacuation: Subjective Motivation and Risk-Sensitive Attitude in a Simulation Experiment
Authors: Takubo Masato ,   Editorial Office, Sugiura Motoaki , Ishibashi Ryo , Miura Naoki , Tanabe-Ishibashi Azumi
Published: January 2024

Videos are commonly used in disaster prevention education or communication. Some consider behavioral recommendations to have more motivating content than hazard mechanisms; these, however, have not been empirically tested. Perception of hazard risk is mediated by risk-sensitive and risk-scrutiny attitudes, but which attitude the videos influence has not been examined. In Experiment 1, we created sets of videos for two types of content and relevant control videos, and their effects on four motivation measures of the self-oriented model (i.e., self-relevance, attention, self-efficacy, and behavioral intention) were examined in the online survey. In Experiment 2, we compared the intervention effects of disaster prevention and control videos on the pre-post change of two types of attitudes using a scenario-based tsunami evacuation decision-making task. Consequently, disaster-prevention videos (vs. control videos) facilitated the four motivation measures irrespective of the content type and increased the risk-sensitive attitude during the evacuation decision-making from the tsunami. The revealed facilitatory effect of the videos on motivational and risk-sensitive aspects of evacuation response appears to be congruent with previously advocated advantages of videos or films. The current finding offers insights into the process and mechanism of the effect of disaster prevention videos, providing a robust empirical basis for promoting their use in disaster prevention education.
The Possibility of Wide Area Evacuation in the Event of Natural Disasters: A Survey in Amagasaki City, Hyogo Prefecture
Authors: Sawada Masahiro ,   Editorial Office, Sato Takao
Published: January 2024

In industrial clusters that are affected by earthquakes and tsunamis, advance countermeasures are necessary to ensure the continuity of business operations of companies. This article presents the results of a questionnaire survey of small- and medium-sized enterprises in Amagasaki City, Hyogo Prefecture, to determine the current status of disaster countermeasures, and a questionnaire survey of residents’ awareness of risks and their current countermeasures.
Developing Critical Thinking Indicators and Research Trends in Islamic Religious Education with VOSviewer
Authors: Nur Aulia Rihlah , Yasnita Yasnita , Amaliyah Amaliyah
Published: January 2024

This research aims to develop indicators of students' critical thinking and find the state of the art by using Vos Viewer. One way to develop critical thinking indicators is through research. The teacher's job besides teaching is to conduct research. Research is said to be good if it finds elements of new findings so that it has a contribution both to science and to life. One of the difficulties in research is finding novelty, nowadays with the Vos Viewer application it is easy to find the novelty of a research variable, such as the critical thinking variable. The research subject is students in Islamic educational institutions. The object or focus of the research is to develop indicators of students' critical thinking in learning Islamic religious education. In addition, the research aims to analyze the opportunities and development of research trends related to critical thinking in Islamic learning. This research is important as a way to help Islamic religious education teachers develop critical thinking indicators as an effort to familiarize students with reading literacy and numeracy in accordance with the demands of the independent curriculum. The method used is bibliometric by collecting article data from 2018-2022 through Google Scholar and Scopus sites with Publish or Perish software for 1,000 journals. The results of the study describe that critical thinking indicators can be developed through familiarizing students with analyzing, evaluating, and analyzing.