bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on Consumer Behaviour of Buying Products towards Insurance Policies in India
Authors: K Meenendranath reddy
Published: December 2023

In spite of the fact that India has the world's second-highest population, the nation's median sales of life insurance products remain significantly less than those in several Western along with Asian countries. As a result, the insurance market in india is seen as highly promising by both international and domestic insurance firms investigating to increase their presence and revenue. The business of insurance has far-reaching positive effects, from providing consumers with more options to ensuring a steady supply of long-term capital for businesses and governments. Since insurance is a relatively untapped market, this development will lead to a surge in demand for both insurance company employees and independent insurance brokers and advisors.

Insurance policies are created to ease the economic strain left behind by a breadwinner's death on his or her loved ones. Diversity, opportunity, advantages, and profitability have all been added to the product lineup thanks to the expansion of the item line. However, the worker is hesitant about buying insurance services because he or she refuses to embrace the danger to his or her life, is uninterested in the benefits that are intended for others and cannot predict the future. The results show that in India's developing finances, many consumers listen to the guidance of their brokers before committing to an insurance coverage. We use the concept of scheduled behaviour to show that individual's perceptions of social standards have a major role in whether or not they would acquire insurance. It was also discovered that social factors had a role in policy decisions. Customers can choose poor choices and purchase insurance plans that could not adequately cover their costs. Consumers in this fast expanding market require more information and awareness campaigns.
Applying Scrum in A Game Development Life Cycle For Small Scale Game Project
Authors: Siahaan Yehezkiel Yosua Parlindungan , Widyani Yani , Candra M. Zuhri Catur
Published: December 2023

This research aims to develop a GDLC game development life cycle that focuses on the core stages of software development process. This GDLC proposal consists of 4 stages, namely Pre-Production, Production, Testing, and Release. This proposed GDLC is expected to provide adaptive but consistent guidance for game project design. These conditions are suitable for small-scale game development teams, with small project scales, and short work periods (under 1 year).

Pre-Production functions as the initial stage for creating the basis game design for the project linearly. Production, which is carried out using the Scrum approach, is the stage of video game development based on that previously made design. The Testing phase ensures the quality of the game through overall game testing. Lastly, the Release phase includes completing documentation for post-release planning.

This GDLC was designed by summarizing the core stages of various existing GDLCs and SDLCs related to multimedia software development. Scrum is implemented per stage, with iteration loops starting and finishing within that stage. However, in general, this GDLC is linear. This GDLC is validated with a case study of an actual video game development to ensire its efficiency in helping game developers.
Estado del arte: prácticas evaluativas en producción textual
Authors: Manjarrés Rojas Yudy Alejandra
Published: December 2023

Este artículo tiene como objetivo fundamental realizar una indagación sobre los estudios realizados a nivel regional (Tolima), nacional (Colombia), e internacional alrededor de la evaluación educativa, las prácticas evaluativas y la producción textual. Al tiempo que, busca fortalecer el trabajo Prácticas evaluativas de la producción textual. Un estudio de caso con docentes del área de castellano de la I.E.T.E. Alberto Castilla de Ibagué, el cual se viene desarrollando para la maestría en Educación de la Universidad del Tolima.

La construcción del estado del arte posibilitó conocer investigaciones finalizadas sobre las categorías en mención, dentro del área de lenguaje, ello, para situar hallazgos positivos y propuestas hechas por docentes e investigadores frente a la evaluación de la escritura en educación básica secundaria. Su realización implicó metodológicamente las siguientes etapas: la búsqueda de información en bases de datos referente a categorías propuestas; compendio de la información suministrada por los textos mediante fichas de sistematización; análisis y sistematización de la información; finalmente, estructuración, revisión y corrección del estado de arte. Ello, permitió establecer una interpretación, contextualización y comprensión de aquellas cuestiones que se convierten en obstáculos para los docentes a la hora de evaluar el factor de producción textual, a su vez, situar vacíos, constantes o tendencias del problema a investigar.
The Long Overdue Fall of Al-Kateb

Authors: McIntyre Joe
Published: December 2023

On the 8th of November, the High Court of Australia delivered a landmark ruling that the indefinite detention regime under the Migration Act is unconstitutional, overruling the 2004 decision of Al-Kateb. The decision, both in form and substance, sent shockwaves through Australia’s legal and political establishment. In adopting the relatively uncommon procedure of issuing orders immediately following the hearing (with reasons to follow), a gap was created where politicians rushed to come up with a legislative response in the absence of any clearly articulated constitutional rules. In an island country, where several elections in the last 20 years have been ostensibly won and lost over concerns of ‘illegal’ immigration, this decision has been political dynamite.
Preparedness and Response for a Nuclear or Radiological Emergency
Authors:   FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS,   INTERNATIONAL ATOMIC ENERGY AGENCY,   NTERNATIONAL CIVIL AVIATION ORGANIZATION,   INTERNATIONAL LABOUR ORGANIZATION,   INTERNATIONAL MARITIME ORGANIZATION,   INTERPOL,   OECD NUCLEAR ENERGY AGENCY,   PAN AMERICAN HEALTH ORGANIZATION,   PREPARATORY COMMISSION FOR THE COMPREHENSIVE NUCLEAR-TEST-BAN TREATY ORGANIZATION,   UNITED NATIONS ENVIRONMENT PROGRAMME,   UNITED NATIONS OFFICE FOR THE COORDINATION OF HUMANITARIAN AFFAIRS,   WORLD HEALTH ORGANIZATION,   WORLD METEOROLOGICAL ORGANIZATION
Published: December 2023

This publication, jointly sponsored by the FAO, IAEA, ICAO, ILO, IMO, INTERPOL, OECD/NEA, PAHO, CTBTO, UNEP, OCHA, WHO and WMO, is the new edition establishing the requirements for preparedness and response for a nuclear or radiological emergency which takes into account the latest experience and developments in the area. It supersedes the previous edition of the Safety Requirements for emergency preparedness and response, Safety Standards Series No. GS-R-2, which was published in 2002. This publication establishes the requirements for ensuring an adequate level of preparedness and response for a nuclear or radiological emergency, irrespective of its cause. These Safety Requirements are intended to be used by governments, emergency response organizations, other authorities at the local, regional and national levels, operating organizations and the regulatory body as well as by relevant international organizations at the international level.
Fundamental Safety Principles
Authors:   EUROPEAN ATOMIC ENERGY COMMUNITY,   FOOD AND AGRICULTURE ORGANIZATION OF THE UNITED NATIONS,   INTERNATIONAL ATOMIC ENERGY AGENCY,   INTERNATIONAL LABOUR ORGANIZATION,   INTERNATIONAL MARITIME ORGANIZATION,   OECD NUCLEAR ENERGY AGENCY,   PAN AMERICAN HEALTH ORGANIZATION,   UNITED NATIONS ENVIRONMENT PROGRAMME,   WORLD HEALTH ORGANIZATION
Published: December 2023

This publication states the fundamental safety objective and ten associated safety principles, and briefly describes their intent and purpose. The fundamental safety objective — to protect people and the environment from harmful effects of ionizing radiation — applies to all circumstances that give rise to radiation risks. The safety principles are applicable, as relevant, throughout the entire lifetime of all facilities and activities, existing and new, utilized for peaceful purposes, and to protective actions to reduce existing radiation risks. They provide the basis for requirements and measures for the protection of people and the environment against radiation risks and for the safety of facilities and activities that give rise to those risks. These include, in particular, nuclear installations and uses of radiation and radioactive sources, the transport of radioactive material and the management of radioactive waste.
ASUHAN KEBIDANAN KOMPREHENSIF PADA NY.M DI KLINIK UTAMA NILAM SARI TEMBILAHAN TAHUN 2022
Authors: Okta Viarika Dwi , Erlina Asrita Sari Dewi
Published: December 2023

Comprehensive care is a series of continuous and comprehensive activities, from pregnancy, childbirth, postpartum, newborn services, family planning (KB), which aims to provide quality services to prevent MMR and AKB. This care aims to be able to provide midwifery services Comprehensive Care. The midwifery management approach method with a varney mindset is outlined in the form of SOAP. Held at Nilam Sari Main Clinic on March 11 – June 5, 2022. Comprehensive obstetric care was carried out on Mrs." M" Age 26 Years G3P1A1H1. Based on the results of the upbringing, ANC went well, the maternity went well, when I lasted for 23 hours, when II lasted for 15 minutes, when III lasted for 15 minutes, and when IV lasted for 2 hours. Babies are born spontaneously, neonatal visits are carried out as much as 3x. The postpartum period went normally, 4x postpartum visits and Mrs. family planning care." M" chose 3-month injectable birth control. There was a gap in the schedule of ANC visits and methergin, from these results it can be concluded that comprehensive care was given to Mrs." M" already meets the standard. It is hoped that the results of this midwifery care can be an input for female students in improving the quality of midwifery care services for pregnant women, childbirth, BBL, postpartum and family.

 

Asuhan komprehensif merupakan serangkaian kegiatan yang berkelanjutan dan menyeluruh, dari kehamilan, persalinan, nifas, pelayanan bayi baru lahir, keluarga berencana (KB), Yang bertujuan untuk memberikan pelayanan yang berkualitas untuk mencegah terjadinya AKI dan AKB. Asuhan ini bertujuan Mampu memberikan pelayanan kebidanan Asuhan Komprhensif. Adapun Metode pendekatan manajemen kebidanan dengan pola fikir varney yang dituangkan dalam bentuk SOAP. Dilaksanakan di Klinik Utama Nilam Sari pada tanggal 11 Maret – 05 Juni 2022. Asuhan kebidanan komprehensif dilakukan  pada Ny.”M” Umur 26 Tahun G3P1A1H1. Bedasarkan hasil asuhan, ANC berjalan dengan baik, ibu bersalin berjalan dengan baik, kala I berlangsung selama 23 jam, kala II berlangsung selama 15 menit, kala III berlangsung selama 15  menit, dan kala IV berlangsung selama 2 jam. Bayi lahir spontan, dilakukan kunjungan neonatus sebanyak 3x. Masa nifas berjalan normal, kunjungan nifas sebanyak 4x dan asuhan keluarga berencana Ny.”M” memilih KB suntik 3 bulan. Terdapat kesenjangan pada jadwal kunjungan ANC dan pemberian methergin, dari hasil tersebut dapat disimpulkan bahwa asuhan komprehensif yang diberikan pada Ny.”M” sudah memenuhi standar. Diharapkan dari hasil asuhan kebidanan ini, dapat menjadi masukan bagi mahasiswi dalam meningkatkan mutu pelayanan asuhan kebidanan pada ibu hamil, persalinan, BBL, nifas dan keluarga.
Toiseutettujen epäuskottaviksi väitetyt tarinat
Authors: Puranen-Impola Karoliina
Published: December 2023

Tässä artikkelissa tarkastelen lastensuojelun sijaishuollossa tapahtuneesta kaltoinkohtelusta julkaistua lehdistökirjoittelua. Artikkelin aineiston muodostavat Kansalliskirjaston digitaaliarkistoon tallennetut lehtiartikkelit, joissa kirjoitettiin lastensuojelussa ilmenneestä kaltoinkohtelusta noin vuosina 1948–2020. Artikkelissa osoitan, että kaltoinkohtelutapauksia nousi julkisuuteen erityisesti 1950-luvulla. Ilmiötä ei kuitenkaan saatu kitkettyä, ja sijaishuollossa tapahtunutta kaltoinkohtelua on ilmennyt vielä 2000-luvullakin. Analysoin artikkelissa niitä reittejä, joita pitkin tapaukset ovat nousseet laajempaan tietoisuuteen sekä tarkastelen tekijöitä, jotka ovat mahdollisesti osaltaan tuottaneet ilmiön ympärillä vallinnutta hiljaisuutta. Kiinnitän huomiota myös siihen, missä määrin sijoitettuja lapsia ja heidän  tarinaansa on toiseutettu ja marginalisoitu. Pohdin, miten toiseuttaminen osaltaan vaikutti kaltoinkohtelun ympärillä vallinneeseen hiljaisuuteen sekä sen pitkittyneeseen luonteeseen.
THE ROLE OF INCOMING TOURISM IN SOCIAL ECONOMIC DEVELOPMENT
Authors: Rzayev Nicat , Əsgərov Rəfail
Published: December 2023

In the article, the main factors of inbound tourism, the role of inbound tourism in social economic development, the main directions in Azerbaijan and the importance of its development, etc. is explained. In addition, the study of inbound tourism in Azerbaijan plays an important role in the development of tourism. The increase in the number of tourists as a result of the investigation of the problems and the measures taken to eliminate them, the recognition of the country by other developed countries is important in all spheres of the economy in Azerbaijan, as well as in increasing the level of the people’s well-being.
Methodology – analysis, synthesis, statistical, economic and comparative analysis methods were used in the research work.
Results of the research – The research work allows to obtain the following results:
 Some evidence-based recommendations are aimed at further developing tourism
industry infrastructure in Azerbaijan:
 Currently, there are stages of formation of the tourist market in the republic. It is
necessary to look for a new form of business of regular tourists.
 In my opinion, the main tasks of travel companies should be as follows:
– full and wide range of leisure and travel opportunities, all available tours, vacations to
tourist centers, etc.;

– promotion of this information through advertising;

– modern trade methods typical of the market economy in accordance with the sale of tourist

products;

– search proposals for resources for the development of new types of tourism.

 Association of young Azerbaijani tourist companies should implement measures aimed at maximizing efficiency, effectiveness of events, profit, and professionalism.

 In the future, in order to solve problems in the field of tourism infrastructure development,

the following areas should be involved: resort business, hotel business, new tourist complexes.
Reliability Evaluation of Professional Assessments
Authors: Charles C Thiel Jr
Published: December 2023

All professional technical assessment processes are fraught with uncertainty. If a decision is premised upon the result, the decision maker must understand the reliability of the performed assessment. A causal theory application is developed utilizing distinct (linguistic, ordered) terms and continuous (numerical) variables. It uncouples the methods from the result of the assessment obtained and focuses on those aspects that are important to the reliability assessment of the conclusion, not the answer itself. Matrices provide a means of characterizing the uncertainty of the methods and information available for each principal issue impacting the reliability. These matrices are determined as paired qualitative assessments of the Quality of the Measures Used and the Quality of Implementation of component description measures. Each is qualified by two to five grades, allowing three, five, seven, or nine quality distinctions for the assessed element. Uncertainty β values are determined for each component of the assessment combined by either an RMS procedure or a weighted average and converting a numerical value back to a consistent linguistic term. This procedure yields a basis for using good judgment while being sensible and reasonably cautious by independently determining the reliability using a carefully considered approach. California State University has assessed seismic retrofit priorities for 56 buildings using this method and has committed to its continuing use as its retrofit priority evaluation tool.
Race-Specific Risk Factors for Homeownership Disparity in the Continental United States
Authors: Richardson Rachel E. , Leach Damon T. , Winans Natalie M. , Degnan David J. , Prymolenna Anastasiya V. , Bramer Lisa M.
Published: December 2023

The United States has a racial homeownership gap due to a legacy of historic inequality and discriminatory policies, but factors that contribute to the racial disparity in homeownership rates between White Americans and people of color have not been fully characterized. In order to alleviate this issue, policymakers need a better understanding of how risk factors affect the homeownership rates of racial and ethnic groups differently. In this study, data from several publicly available surveys, including the American Community Survey and United States Census, were leveraged in combination with statistical learning models to investigate potential factors related to homeownership rates across racial and ethnic categories, with a focus on how risk factors vary by race or ethnicity. Our models indicated that job availability for specific demographics, and specific regions of the United States were factors that affect homeownership rates in Black, Hispanic, and Asian populations in different ways. Based on the results of this study, it is recommended policymakers promote strategies to increase access to jobs for people of color (POC), such as vocational training and programs to reduce implicit bias in hiring practices. These interventions could ultimately increase homeownership rates for POC and be a step toward reducing the racial wealth gap.
Mourir chez soi comme paradigme du bien mourir en contexte québécois : une analyse différenciée selon le genre
Authors: Lessard Émilie
Published: December 2023

La diversité des expériences du mourir dans les sociétés contemporaines occidentales semble occultée par le paradigme dichotomique de la bonne et de la mauvaise mort. Cette construction sociale met en échec les personnes qui ne parviennent pas à se conformer aux critères de la bonne mort. Dans ce contexte et celui du vieillissement de la population québécoise, le domicile apparaît à la personne en fin de vie comme le lieu idéal pour vieillir et mourir, parce qu’il lui permet de conserver son autonomie et d’exercer un contrôle sur la trajectoire de la fin de vie. Bien que la nouvelle approche de santé publique en soins palliatifs vise une réappropriation des expériences de la fin de vie et de la mort à l’extérieur des institutions de soins, peu d’études se sont intéressées à l’influence du genre sur ces expériences. Cet article met en lumière les différences attribuables au genre qui ont été perçues par des proches aidants en contexte de soins palliatifs à domicile au Québec, selon leurs témoignages recueillis dans le cadre d’une recherche plus vaste menée pour l’obtention d’un doctorat.
Retos del diseño de producto circular en el corazón de la industria valenciana. Nuevos roles del/a diseñador/a
Authors: Brotóns Brotóns Irene , Galán Serrano Julia , Felip Miralles Francisco
Published: December 2023

En la actualidad, el diseño juega un papel clave en el marco de la economía circular que sustenta las políticas y regulaciones europeas. Con el objetivo de conseguir una Unión Europea climáticamente neutra para el año 2050, la Comisión Europea propone una nueva hoja de ruta para el diseño, en la transición ecológica de una economía lineal a una economía circular.

Para contribuir al avance del conocimiento, el artículo expone un caso práctico, desarrollado y producido en la industria alicantina desde el año 2020. El proyecto de diseño de calzado de la marca Urbànima basó su estrategia de ecodiseño en el Pacto Verde Europeo. La investigación pone de manifiesto el estado evolutivo de la economía circular en la industria local, examinando la disponibilidad de materiales, tecnologías y sistemas para la circularidad, y propone futuras líneas de trabajo para una revisión eficaz de la metodología proyectual del diseño de producto tras la circularidad.
Philostratus in the Aldine Edition of the Ancient Greek Epistolographers
Authors: Cejudo Rafael J. Gallé
Published: December 2023

Based on the studies by Dimitrios K. Raios and Martin Sicherl, this article
reviews some of the main hypotheses proposed concerning the genesis of
Philostratus’s collected letters before and during the process of their
inclusion in the Aldine edition by the scholar Marcus Musurus. This very
preliminary analysis of the relationships between the codices most directly
involved in the production of the Aldine edition suggests some initial
conclusions which, although not definitive, call these hypotheses into
question.
Application of terahertz spectroscopy in identification of transgenic rapeseed oils: A support vector machine model based on modified mayfly optimization algorithm
Authors: Chen Tao , Li Xin ,   School of Electronic Engineering and Automation, Guilin University of Electronic Technology, Guilin 541004, China
Published: December 2023

To achieve rapid and accurate identification of genetically modified (GM) and non-GM rapeseed oils, a support vector machine (SVM) model based on an improved mayfly optimization algorithm and coupled with the terahertz time-domain spectroscopy, is proposed. Two types of GM rapeseed oils and two types of non-GM rapeseed oils are selected as research subjects. Their spectral information is acquired by using the terahertz time-domain spectroscopy. The observations show that GM rapeseed oils exhibit stronger terahertz absorption characteristics than non-GM rapeseed oils. However, their absorption spectra are highly similar, making direct differentiation difficult through visual inspection alone. Therefore, SVM is used for spectral recognition. Considering that the classification performance of SVM is significantly affected by its parameters, the mayfly optimization algorithm is combined to optimize these parameters. Furthermore, adaptive inertia weight and Lévy flight strategies are introduced to enhance the global search capability and robustness of the mayfly optimization algorithm, thus addressing the issue of easily becoming trapped in local optima in the optimization process. Moreover, principal component analysis is used to reduce the dimensionality of the absorbance data in a 0.3–1.8 THz range, aiming to extract critical features, thereby enhancing modeling efficiency and reducing redundancy in spectral data. Experimental results demonstrate that the improved mayfly optimization algorithm effectively identifies the optimal parameter combination for SVM, thereby enhancing the overall performance of the identification model. The proposed SVM model, in which the improved mayfly optimization algorithm is used, can achieve a recognition accuracy of 100% for the four types of rapeseed oils, surpassing the 98.15% accuracy achieved by the SVM model with the original mayfly optimization algorithm. Thus, this study presents a rapid and effective new approach for identifying GM rapeseed oils and offers a valuable reference for identifying other genetically modified substances.
Adhesion properties of MoS2/SiO2 interface: Size and temperature effects
Authors: Duan Cong , Liu Jun-Jie , Chen Yong-Jie , Zuo Hui-Ling , Dong Jian-Sheng , Ouyang Gang ,   Department of Physics, Jishou University, Jishou 416000, China,   Key Laboratory of Low-Dimensional Quantum Structures and Quantum Control of Ministry of Education, School of Physics and Electronics, Hunan Normal University, Changsha 410006, China
Published: December 2023

The interface adhesion properties are crucial for designing and fabricating two-dimensional materials and related nanoelectronic and nanomechanical devices. Although some progress of the interface adhesion properties of two-dimensional materials has been made, the underlying mechanism behind the size and temperature dependence of interface adhesion energy and related physical properties from the perspective of atomistic origin remain unclear. In this work, we investigate the effects of size and temperature on the thermal expansion coefficient and Young’s modulus of MoS2 as well as interface adhesion energy of MoS2/SiO2 based on the atomic-bond-relaxation approach and continuum medium mechanics. It is found that the thermal expansion coefficient of monolayer MoS2 is significantly larger than that of its few-layer and bulk counterparts under the condition of ambient temperature due to size effect and its influence on Debye temperature, whereas the thermal expansion coefficient increases with temperature going up and almost tends to a constant as the temperature approaches the Debye temperature. Moreover, the variations of bond identity induced by size effect and temperature effect will change the mechanical properties of MoS2. When the temperature is fixed, the Young’s modulus of MoS2 increases with size decreasing. However, the thermal strain induces the volume expansion, resulting in the Young’s modulus of MoS2 decreasing. Furthermore, the size and temperature dependence of lattice strain, mismatch strain of interface, and Young’s modulus will lead the van der Waals interaction energy and elastic strain energy to change, resulting in the change of interface adhesion energy of MoS2/SiO2. Noticeably, the interface adhesion energy of MoS2/SiO2 gradually increases with MoS2 size decreasing, while the thermal strain induced by temperature causes interface adhesion energy of MoS2/SiO2 to decrease with temperature increasing. In addition, we predict the conditions of the interface separation of MoS2/SiO2 under different sizes and temperatures. Our results demonstrate that increasing both size and temperature can significantly reduce the interface adhesion energy, which is of great benefit in detaching MoS2 film from the substrate. Therefore, the proposed theory not only clarifies the physical mechanism regarding the interface adhesion properties of transition metal dichalcogenides (TMDs) membranes, but also provides an effective way to design TMDs-based nanodevices for desirable applications.
Auditory brainstem responses in the nine-banded armadillo (Dasypus novemcinctus)
Authors: Moffitt Thomas Brad , Atcherson Samuel , Padberg Jeffrey
Published: December 2023

The auditory brainstem response (ABR) to tone burst stimuli of thirteen frequencies ranging from 0.5 to 48 kHz was recorded in the nine-banded armadillo (Dasypus novemcinctus), the only extant member of the placental mammal superorder Xenarthra in North America. The armadillo ABR consisted of five main peaks that were visible within the first 10 ms when stimuli were presented at high intensities. The latency of peak I of the armadillo ABR increased as stimulus intensity decreased by an average of 20 μs/dB. Estimated frequency-specific thresholds identified by the ABR were used to construct an estimate of the armadillo audiogram describing the mean thresholds of the eight animals tested. The majority of animals tested (six out of eight) exhibited clear responses to stimuli from 0.5 to 38 kHz, and two animals exhibited responses to stimuli of 48 kHz. Across all cases, the lowest thresholds were observed for frequencies from 8 to 12 kHz. Overall, we observed that the armadillo estimated audiogram bears a similar pattern as those observed using ABR in members of other mammalian clades, including marsupials and later-derived placental mammals.
Invasive success of star weed (Parthenium hysterophorus L.) through alteration in structural and functional peculiarities
Authors: Iqbal Ummar , Usman Zartasha , Azam Akkasha , Abbas Hina , Mehmood Ansar , Ahmad Khawaja Shafique
Published: December 2023

Parthenium weed poses significant threats to cropping systems, socioeconomic structures, and native ecosystems. The pronounced impact is primarily attributed to its rapid and efficient invasion mechanism. Despite that the detrimental effects of Parthenium weed are widely acknowledged, an in-depth scientific comprehension of its invasion mechanism, particularly regarding modifications in structural and functional attributes under natural conditions, is still lacking. To bridge this knowledge gap and formulate effective strategies for alleviating the adverse consequences of Parthenium weed, a study was conducted in the more cultivated and densely populated areas of Punjab, Pakistan. This study was focused on fifteen distinct populations of the star weed (Parthenium hysterophorus L.) to investigate the factors contributing to its widespread distribution in diverse environmental conditions. The results revealed significant variations in growth performance, physiological traits, and internal structures among populations from different habitats. The populations from wastelands exhibited superior growth, with higher accumulation of soluble proteins (TSP) and chlorophyll content (Chl a&b, TChl, Car, and Chl a/b). These populations displayed increased root and stem area, storage parenchyma, vascular bundle area, metaxylem area, and phloem area. Significant leaf modifications included thicker leaves, sclarification around vascular bundles, and widened metaxylem vessels. Roadside populations possessed larger leaf area, enhanced antioxidant activity, increased thickness of leaves in terms of midrib and lamina, and a higher cortical proportion. Populations found in agricultural fields depicted enhanced shoot biomass production, higher levels of chlorophyll b, and an increased total chlorophyll/carotenoid ratio. Additionally, they exhibited increased phloem area in their roots, stems, and leaves, with a thick epidermis only in the stem. All these outcomes of the study revealed explicit structural and functional modifications among P. hysterophorus populations collected from different habitats. These variations were attributed to the environmental variability and could contribute to the widespread distribution of this species. Notably, these findings hold practical significance for agronomists and ecologists, offering valuable insights for the future management of Parthenium weed in novel environments and contributing to the stability of ecosystems.
CXCL10-based gene cluster model serves as a potential diagnostic biomarker for premature ovarian failure
Authors: Qin Ying , Wen Canliang , Wu Huijiao
Published: December 2023

Objective

Premature ovarian failure (POF) is a disease with high clinical heterogeneity. Subsequently, its diagnosis is challenging. CXCL10 which is a small signaling protein involved in immune response and inflammation may have diagnostic potential in detection of premature ovarian insufficiency. Therefore, this study aimed to investigate CXCL10 based diagnostic biomarkers for POF.

Methods

Transcriptome data for POF was obtained from the Gene Expression Omnibus (GEO) database (GSE39501). Principal component analysis (PCA) assessed CXCL10 expression in patients with POF. The receiver operating characteristic (ROC) curve, analyzed using PlotROC, demonstrated the diagnostic potential of CXCL10 and CXCL10-based models for POF. Differentially expressed genes (DEGs) in the control group of POF were identified using DEbylimma. PlotVenn was used to determine the overlap between the POF-control group and the high-/low-expression CXCL10 groups. QuadrantPlot was employed to detect CXCL10-dysregulated genes in POF. Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), and Gene Set Enrichment Analysis (GSEA) were conducted on DEGs using RunMulti Group cluster Profiler. A POF model was induced with cisplatin (DDP) using KGN cells. RT-qPCR and Western blot were used to measure the expression of CXCL10, apoptosis-related proteins, and peroxisome proliferator–activated receptor (PPAR) signaling pathway-related proteins in this model, following siRNA-mediated silencing of CXCL10. Flow cytometry was employed to assess the apoptosis of KGN cells after CXCL10 downregulation.

Results

The expression of CXCL10 is dysregulated in POF, and it shows promising diagnostic potential for POF, as evidenced by an area under the curve value of 1. In POF, we found 3,362 up-regulated and 3,969 down-regulated DEGs compared to healthy controls, while the high- and low-expression groups of POF (comprising samples above and below the median CXCL10 expression) exhibited 1,304 up-regulated and 1,315 down-regulated DEGs. Among these, 786 DEGs consistently displayed dysregulation in POF due to CXCL10 influence. Enrichment analysis indicated that the PPAR signaling pathway was activated by CXCL10 in POF. The CXCL10-based model (including CXCL10, Itga2, and Raf1) holds potential as a diagnostic biomarker for POF. Additionally, in the DDP-induced KGN cell model, interfering with CXCL10 expression promoted the secretion of estradiol, and reduced apoptosis. Furthermore, CXCL10 silencing led to decreased expression levels of PPARβ and long-chain acyl-CoA synthetase 1 compared to the Si-NC group. These results suggest that CXCL10 influences the progression of POF through the PPAR signaling pathway.

Conclusion

The CXCL10-based model, demonstrating perfect diagnostic accuracy for POF and comprising CXCL10, Itga2, and Raf1, holds potential as a valuable diagnostic biomarker. Thus, the expression levels of these genes may collectively provide valuable diagnostic information for POF.
Review of The Perils of Interpreting: The Extraordinary Lives of Two Translators between Qing China and the British Empire
Authors: Saussy Haun
Published: December 2023

The Perils of Interpreting: The Extraordinary Lives of Two Translators between Qing China and the British Empire. By Henrietta Harrison. Princeton: Princeton University Press, 2021 . Pp . xiv + 329. $30.
O CIBERACONTECIMENTO DA VIOLÊNCIA DE GÊNERO: UMA ANÁLISE TEMÁTICA DO CASO MARIANA MADURO
Authors: Rossa Letícia , De Souza Juliana Borba
Published: December 2023

A violência de gênero atravessa movimentos cotidianos e gera, a cada dia, novos e inesperados acontecimentos. Por vezes, estas ocorrências são desencadeadas por meio do jornalismo – e, com isso, configuram-se enquanto acontecimento jornalístico. O digital interfere nestes processos, especialmente devido à instantaneidade de sua divulgação. Deste modo, a respectiva pesquisa se propõe a compreender como se dá a construção jornalística do processo de ciberacontecimento a partir da violência de gênero do caso Mariana Maduro. Como resultado mais expressivo a partir da Análise de Conteúdo, se considera que o discurso do jornalismo ainda é raso e carece de maiores explicações e aprofundamentos relativos à violência de gênero.
DISCURSIVIDADES PRESENTES EN LAS LETRAS DE LAS CANCIONES EVANGÉLICAS
Authors: Soares Thiago Barbosa
Published: December 2023

Este artículo tiene como objetivo investigar cómo la discursividad presente en las letras de las canciones góspel se (re)produce a partir de mecanismos que son responsables de crear efectos de sentido derivados no sólo del discurso religioso, sino de otros que circulan en la sociedad. Siendo el propósito de este artículo investigar cómo la discursividad presente en las letras de canciones góspel -es decir que la musicalidad y la estructura compositiva de las canciones deben ser estudiadas según criterios específicos que no caben aquí, que es (re)producida a partir de mecanismos encargados de crear efectos de sentidos provenientes no sólo del discurso religioso, sino de la relación con otros discursos que circulan en la sociedad, utilizamos, para tal propósito, el marco teórico y metodológico del Análisis del Discurso para así analizar las letras de tres canciones góspel, a saber: “Una canción de amor para ti" (Catedral), "El tiempo" (Oficina G3) y " Resucítame" (Aline Barros)[1]. En ellas describimos e interpretamos el funcionamiento de los sentidos que circulan en el entorno social, considerando las circunstancias en las que emergen. Para ello, empleamos los conceptos de discurso, condiciones de producción, preconstruido, formación discursiva, interdiscurso/intradiscurso, entre otros, con el fin de verificar una determinada red discursiva, su alcance, interconexión y, sobre todo, la imbricación de estas formaciones discursivas que delimitan los sentidos religiosos en las canciones góspel. Se pudo comprobar, entre otros resultados, que las letras de las canciones aquí analizadas se inscriben en un universo mediático en el que ganaron o siguen ganando protagonismo. Además, se percibe que las propias condiciones de producción y surgimiento de las canciones se materializan en las letras. Así, aliado a los elementos de la vida cotidiana, el discurso religioso adquiere cada vez más un nuevo impulso.

[1] Traducción libre de: “Uma canção de amor pra você” (Catedral), “O tempo” (Oficina G3) e “Ressuscita-me” (Aline Barros).
Nutritional Quality, Amino Acid Profile and Phytochemicals of High Protein-fibre Cookies Produced from Whole Wheat, Orange-fleshed Sweet Potato, Defatted Peanut and Rice Bran Composite Flour
Authors: Chiedu Udeh Charles , Abiodun Malomo Sunday , Steve Ijarotimi Oluwole , Joy Arogundade Toyin
Published: December 2023

This study evaluated the nutritional qualities of cookies from whole wheat (WW), orange-fleshed sweet potato (OFSP), defatted peanut (DPN) and rice bran (RB) composite flour. The flours (WPRG 1, 2 and 3) were formulated at different ratios (5.00-37.50%) and 100% WW flour (as control). The improved protein (13.54 ̵ 18.91%) and fibre (2.96 ̵ 8.65%) of the cookies depicted the positive inclusion of OFSP, DPN and RB flours. However, the essential minerals were significantly (p≤0.05) high in the composite cookies with no traces of heavy metals. Besides, the hydrophobic amino acids (24.10 ̵ 28.91%) and biological value (74.07 ̵ 89.77%) of the cookies showcased their potential bio-availability in some cardio-disease management. Their phenol (100.28-220.35 mg/100g) and tannin (53.40-76.50 mg/100 g) contents significantly (p≤0.05) enhanced their antioxidative power. The cookies produced from 56.25% WW, 18.75% OFSP, 5% RB and 20% DPN composite flour were mostly preferred by the consumers’ ratings. Finally, the added peanut and rice bran flours showed no significant (p<0.05) effect on the physical properties, acceptability and preference of the cookie samples. Hence, we conclude that it is possible to produce better and high nutritional (protein, fibre, etc.) cookies from whole wheat, OFSP, defatted peanut and rice bran composite flours.
The Prevalence of Candida Species among HIV-Positive Women in Aluu, Nigeria: A Call for Awareness
Authors: Cookey T. I.  , Ihejirika M. O.  , Osuala O. J.  , Onu, E. N.  , Amadi, B. O.  , Oketah, E. N.  , Adim, C. C.  , Innocent-Adiele H. C.  , Okonko I. O.
Published: December 2023

Background: The acquired immune deficiency syndrome (AIDS), which HIV brings on, is a major public health concern. The human immunodeficiency virus (HIV) is still a pandemic. Only 2.1% of HIV cases worldwide are recorded in Nigeria. Usually, under the control of the immune system, Candida infections may be dangerous for immunocompromised people, particularly those living with HIV/AIDS.

Aim: At the Mbodo Health Centre in Aluu, Rivers State, Nigeria, this study aimed to assess the prevalence of Candida infections and their relationship to HIV-positive patients.

Methods: Fifty HIV-positive women were chosen at random. Self-collected oral and vaginal swabs were used to gather data. To identify Candida species, biochemical testing, culture, and microscopy were used.

Results: Eighty percent of the 50 individuals had positive candidiasis tests. Oral and vaginal mono/co-candidiasis were found to be common, with Candida albicans being the most common specie. Based on demographic parameters, statistical analysis did not show a significant difference in the prevalence of oral candidiasis. The frequency of vaginal candidiasis was much greater in those with secondary education and aged 31-40 years. The age group of 31 to 40 years old had a considerably greater co-occurrence rate of oral and vaginal candidiasis. Adult female HIV-positive patients at Mbodo Health Centre have a significant prevalence of candidiasis.

Conclusion: The study sheds light on the distribution of Candida species and how demographic variables relate to them. These results highlight the significance of treating candidiasis as a serious health issue in people living with HIV. To improve overall health outcomes for HIV-positive people and reduce related risk factors, further research and treatments may be required.
Germination and Initial Growth Performance of Anadenanthera macrocarpa (Benth.) in Different Substrates
Authors: Teles Simone Pereira , Barros Daniella Inácio , Nunes Helber Veras , Oliveira Liomar Borges de , Costa Sergio José da , Libório Ricardo Alencar , Mattje Vanessa Mendes , Sousa Arthur Costa , Santos Jefferson Ribeiro dos , Barbosa Geovana Rodrigues , Veras Pillar Barros , Nunes Bruno Henrique di Napoli
Published: December 2023

Seed germination is considered the crucial phase in the establishment and development of plants. Knowledge about the appropriate conditions for seed germination is of fundamental importance, mainly due to the influence and different responses that they can present depending on several factors such as seed viability, light, water, oxygen, temperature, and substrate, among others. Therefore, the main objective of the work was to evaluate the germination and the initial development of the A. macrocarpa in the function of different substrates. The experimental design adopted was completely randomized, where six different substrates were used in four replications. The treatments consisted of S1 (Commercial Substrate); S2 (Washed Sand); S3 (Commercial Substrate 50% + Vermiculite 50%); S4 (Commercial substrate 50% + Rice straw 25% + Pine bark powder 25%); S5 (Black Soil); S6 (Black Soil 75% + Sawdust 25%). The evaluated characteristics were germination percentage (%), emergence speed index, shoot and root length (cm), shoot and root fresh mass (gram), and shoot and root dry mass (gram). The use of commercial substrate + vermiculite stood out for most of the analyzed characteristics, being germination (78.57%), aerial part fresh mass (0.1187g), root fresh mass (0.0263g), aerial part dry mass (0.0689g) and root dry mass (0.0149g). The lowest averages observed for all characteristics were with the use of black soil substrate.
Percutaneous Creation of Gastrointestinal Anastomosis—An Emerging Frontier
Authors: Klein Erez , Barragan Camilo , Shlomovitz Eran
Published: December 2023

This article discusses the percutaneous delivery and deployment of lumen-apposing metallic stents for the creation of percutaneous cholecysto-enteric anastomoses for internal drainage of the gallbladder.
Benign Breast Disease and Breast Cancer Risk in the Percutaneous Biopsy Era
Authors: Sherman Mark E. , Vierkant Robert A. , Winham Stacey J. , Vachon Celine M. , Carter Jodi M. , Pacheco-Spann Laura , Jensen Matthew R. , McCauley Bryan M. , Hoskin Tanya L. , Seymour Lisa , Gehling Denice , Fischer Jessica , Ghosh Karthik , Radisky Derek C. , Degnim Amy C.
Published: December 2023

Importance

Benign breast disease (BBD) comprises approximately 75% of breast biopsy diagnoses. Surgical biopsy specimens diagnosed as nonproliferative (NP), proliferative disease without atypia (PDWA), or atypical hyperplasia (AH) are associated with increasing breast cancer (BC) risk; however, knowledge is limited on risk associated with percutaneously diagnosed BBD.

Objectives

To estimate BC risk associated with BBD in the percutaneous biopsy era irrespective of surgical biopsy.

Design, Setting, and Participants

In this retrospective cohort study, BBD biopsy specimens collected from January 1, 2002, to December 31, 2013, from patients with BBD at Mayo Clinic in Rochester, Minnesota, were reviewed by 2 pathologists masked to outcomes. Women were followed up from 6 months after biopsy until censoring, BC diagnosis, or December 31, 2021.

Exposure

Benign breast disease classification and multiplicity by pathology panel review.

Main Outcomes

The main outcome was diagnosis of BC overall and stratified as ductal carcinoma in situ (DCIS) or invasive BC. Risk for presence vs absence of BBD lesions was assessed by Cox proportional hazards regression. Risk in patients with BBD compared with female breast cancer incidence rates from the Iowa Surveillance, Epidemiology, and End Results (SEER) program were estimated.

Results

Among 4819 female participants, median age was 51 years (IQR, 43-62 years). Median follow-up was 10.9 years (IQR, 7.7-14.2 years) for control individuals without BC vs 6.6 years (IQR, 3.7-10.1 years) for patients with BC. Risk was higher in the cohort with BBD than in SEER data: BC overall (standard incidence ratio [SIR], 1.95; 95% CI, 1.76-2.17), invasive BC (SIR, 1.56; 95% CI, 1.37-1.78), and DCIS (SIR, 3.10; 95% CI, 2.54-3.77). The SIRs increased with increasing BBD severity (1.42 [95% CI, 1.19-1.71] for NP, 2.19 [95% CI, 1.88-2.54] for PDWA, and 3.91 [95% CI, 2.97-5.14] for AH), comparable to surgical cohorts with BBD. Risk also increased with increasing lesion multiplicity (SIR: 2.40 [95% CI, 2.06-2.79] for ≥3 foci of NP, 3.72 [95% CI, 2.31-5.99] for ≥3 foci of PDWA, and 5.29 [95% CI, 3.37-8.29] for ≥3 foci of AH). Ten-year BC cumulative incidence was 4.3% for NP, 6.6% for PDWA, and 14.6% for AH vs an expected population cumulative incidence of 2.9%.

Conclusions and Relevance

In this contemporary cohort study of women diagnosed with BBD in the percutaneous biopsy era, overall risk of BC was increased vs the general population (DCIS and invasive cancer combined), similar to that in historical BBD cohorts. Development and validation of pathologic classifications including both BBD severity and multiplicity may enable improved BC risk stratification.
Trim21 Regulates the Postnatal Development and Thermogenesis of Brown Adipose Tissue
Authors: Hu Qinxiao , Xu Yidi , Xiao Teng , Peng Rui , Li Zhenwei , Xu Guisheng , Yu Bo , Li Jianping , Li Zhen‐Yan , Hou Huige , Lin Yuning , Cao Jiahui , Liu Ning , Zha Zhen‐Gang , Gui Tao , Zhang Huan‐Tian , Cai Yuebo
Published: December 2023

Brown adipose tissue undergoes rapid postnatal development to mature and plays a crucial role in thermoregulation and energy expenditure, which protects against cold and obesity. Herein, it is shown that the expression of Trim21 mRNA level of interscapular brown adipose tissue elevates after birth, and peaks at P14 (postnatal day 14). Trim21 depletion severely impairs the maturation of interscapular brown adipose tissue, decreases the expression of a series of thermogenic genes, and reduces energy expenditure. Consistently, the loss of Trim21 also leads to a suppression of white adipose tissue “browning”, in response to cold exposure and a β‐adrenergic agonist, CL316,243. In addition, Trim21−/− mice are more prone to high‐fat diet‐induced obesity compared with the control littermates. Taken together, the study for the first time reveals a critical role of Trim21 in regulating iBAT postnatal development and thermogenesis.