bluuebunny/crossref_metadata_2025 huggingface dataset:
Right ventricular stroke volume assessed by pulmonary artery pulse contour analysis
Authors: Berger David , Hobi Jan , Möller Per W. , Haenggi Matthias , Takala Jukka , Jakob Stephan M.
Published: October 2020

Background

Stroke volume measurement should provide estimates of acute treatment responses. The current pulse contour method estimates left ventricle stroke volume. Heart-lung interactions change right ventricular stroke volume acutely. We investigated the accuracy, precision, and trending abilities of four calibrated stroke volume estimates based on pulmonary artery pulse contour analysis.

Results

Stroke volume was measured in 9 pigs with a pulmonary artery ultrasound flow probe at 5 and 10 cmH2O of PEEP and three volume states (baseline, bleeding, and retransfusion) and compared against stroke volume estimates of four calibrated pulmonary pulse contour algorithms based on pulse pressure or pressure integration. Bland-Altman comparison with correction for multiple measurements and trend analysis were performed. Heart rate and stroke volumes were 104 ± 24 bpm and 30 ± 12 mL, respectively. The stroke volume estimates had a minimal bias: − 0.11 mL (95% CI − 0.55 to 0.33) to 0.32 mL (95% CI − 0.06 to 0.70). The limits of agreement were − 8.0 to 7.8 mL for calibrated pulse pressure to − 10.4 to 11.5 mL for time corrected pressure integration, resulting in a percentage error of 36 to 37%. The calibrated pulse pressure method performed best. Changes in stroke volume were trended very well (concordance rates 73–100%, r2 0.26 to 0.987, for pulse pressure methods and 71–100%, r2 0.236 to 0.977, for integration methods).

Conclusions

Pulmonary artery pulse contour methods reliably detect acute changes in stroke volume with good accuracy and moderate precision and accurately trend short-term changes in cardiac output over time.
Gamifying learning for learners
Authors: Dichev Christo , Dicheva Darina , Irwin Keith
Published: October 2020

The majority of user models in gamification are based on user’s gamer personality. However, the motivations driving individuals’ learning behavior differ from their motivations when playing. There is no evidence that learners’ experiences in gamified activities are described by these models. Thus, an alternative model capturing learners’ motivational experiences and relating them to the motivational mechanisms of gamification design is needed. To fill this gap we propose a context-specific typology which groups learners based on their type of motivation and perceived ability associated with a learning activity. The purpose of this proposal is to provide a framework for connecting each learner’s type to a set of motivational affordances to which that type is susceptible. Facilitating the task of selecting motivational affordances matching learner’s type aids the design of customized gamified learning.
Physical activity in established rheumatoid arthritis and variables associated with maintenance of physical activity over a seven-year period – a longitudinal observational study
Authors: Bremander Ann , Malm Karina , Andersson Maria L. ,   on behalf of the BARFOT study group
Published: October 2020

Background

A large number of patients with RA do not adhere to the recommended levels of physical activity to enhance health. According to EULAR recommendations, physical activity should be part of standard care in people with rheumatic diseases. There have been few larger studies on maintenance of physical activity over longer periods of time. The aim was to study self-reported physical activity levels over 7 years in patients with established rheumatoid arthritis (RA). In addition, to determine variables associated with maintenance or change of physical activity behavior.

Methods

Questionnaires were sent to the BARFOT cohort in 2010 (n = 1525) and in 2017 (n = 1046), and 950 patients responded to both questionnaires. Patients were dichotomized according to meeting MVPA recommendations (physically active at a moderate level ≥ 150 min/week or at an intense level ≥ 75 min/week) or not. Body mass index, smoking habits, tender joint count (TJC), swollen joint count (SJC), Patient Global Assessment (PatGA), pain intensity and distribution, fatigue, physical function (HAQ), health-related quality of life (EQ. 5D), comorbidities, and medical treatment were assessed. We used logistic regression analysis to study variables associated with maintenance and/or change of MVPA behavior.

Results

Forty-one per cent (n = 389) of the patients met MVPA recommendations on both occasions. Patients who met MVPA recommendations over 7 years were younger and a higher proportion were never-smokers. There was a negative association with being overweight or obese, having cardiovascular or pulmonary diseases, pain, fatigue, and physical function, whereas there was a positive association between QoL and maintaining MVPA recommendations. Similar factors were positively associated with a deterioration in physical activity level over time.

Conclusions

Maintenance of physical activity over a long period of time is challenging for patients with established RA. Reports of high quality of life supported maintenance of physical activity while disease related and unhealthy lifestyle factors had a negative effect. Health professionals should consider the patient’s standpoint when encouraging maintenance of physical activity, preferably using coordinated lifestyle interventions.
Cystic neutrophilic granulomatous mastitis during chemotherapy treatment for invasive breast carcinoma – a rare lesion that simulates tumor progression
Authors: de Freitas Juliana Ribeiro , de Souza Maiara Ferreira , Lopes Mayana , Bitencourt Larissa , Athanazio Daniel Abensur
Published: October 2020

Background

Cystic neutrophilic granulomatous mastitis (CNGM) is an uncommon and recently described pattern of granulomatous mastitis. To our knowledge, no cases have been described during chemotherapy for invasive breast cancer.

Case presentation

A 42-year-old female patient had a diagnosis of invasive breast carcinoma (3-cm nodule). During neoadjuvant chemotherapy, she presented with an enlargement of the breast nodule that measured 7.0-cm on palpation. The lesion did not show typical inflammatory clinical findings and simulated tumor progression. A core biopsy showed granulomas with pseudocystic spaces with gram-positive bacilli (Corynebacterium sp.), and numerous circumjacent neutrophils. She was treated with antibiotics and resumed chemotherapy. Surgical specimen showed a 1.0-cm residual carcinoma and extensive xanthogranulomatous inflammation with no evidence of residual CNGM.

Conclusion

CNGM is usually associated with typical clinical presentation of mastitis. It is an important pattern of granulomatous inflammation to be recognized in the breast since it directly impacts treatment. The present case highlights its potential occurrence during chemotherapy treatment of breast cancer mimicking progression of breast malignancy.
A comparative study between effect of combined intravenous and nebulized amikacin versus intravenous amikacin alone in mechanically ventilated patients with ventilator-associated pneumonia (VAP)
Authors: El Fawy Dalia M. , Ibrahim Azza Yousef , Abdulmageed Ahmed Mostafa Mohamed , El Seddek Eman Abo Bakr
Published: October 2020

Background

Aerosolized antibiotic administration offers the theoretical advantages of achieving high drug concentrations at the infection site together with lower systemic absorption. This study aims to compare the effect of combining nebulized amikacin with intravenous amikacin to the effect of the usual intravenous route alone in the treatment of patients with ventilator-associated pneumonia and its impact on the duration of mechanical ventilation, laboratory, and clinical picture of the patients.

Results

This study was carried out on 64 mechanically ventilated patients with Gram-negative VAP. The patients were divided into 2 groups. Group A included 32 patients treated with nebulized amikacin plus IV amikacin, and group B included 32 patients treated with IV amikacin alone. The duration of treatment for both groups was 8 days with a daily assessment of Clinical Pulmonary Infection Score (CPIS) and monitoring of clinical and laboratory parameters. Sputum cultures were obtained thereafter. In our study, the CPIS score and overall ICU mortality were less in the nebulized than in the IV group but the difference failed to be statistically significant. Increase of oxygenation level (Pao2/Fio2 ratio), organism clearance, decrease in serum creatinine level, duration of mechanical ventilation, and length of ICU stay were significantly different in favor of group A than group B.

Conclusion

Nebulized and IV amikacin offered better oxygenation, organism clearance, less nephrotoxicity, and less duration of mechanical ventilation and ICU stay than the IV group. Combined and IV routes were comparable regarding the decrease in CPIS score and ICU mortality with no significant difference between them. However, we prefer to use the combined regimen for the mentioned reasons. Further large-scale studies are required to confirm these findings and to establish a definite conclusion.
Can an AI learn political theory?
Authors: DeCanio Stephen J.
Published: October 2020

Alan Turing’s 1950 paper, “Computing Machinery and Intelligence,” contains much more than its proposal of the “Turing Test.” Turing imagined the development of what we today call AI by a process akin to the education of a child. Thus, while Turing anticipated “machine learning,” his prescience brings to the foreground the yet unsolved problem of how humans might teach or shape AIs to behave in ways that align with moral standards. Part of the teaching process is likely to entail AIs’ absorbing lessons from human writings. Natural language processing tools are one of the ways computer systems extract knowledge from texts. An example is given of how one such technique, Latent Dirichlet Allocation, can draw out the most prominent themes from works of classical political theory.
Detection of additional primary malignant tumor in cancer survivors: the use of PET/CT for image-guided biopsy
Authors: Shaban Ekhlas , Saleh Rasha
Published: October 2020

Background

PET/CT is a well-established tool in the diagnostic workup of oncology patients. With the advance in diagnosis and therapy of oncology patients, survivors are at risk of developing additional malignancies. This study aimed to evaluate the yield of 18F-FDG PET/CT in biopsy guidance for the detection of unexpected additional primary malignancies in patients with known primary cancers. Medical records of patients underwent 18F-FDG PET/CT scans from July 2015 to December 2017 were reviewed, and 644 patients (346 men and 298 women; mean age 59.7, age range from 21: 78) who had been scanned for known cancers were included in this study. Lesions that were newly detected on PET/CT had not been previously detected by other modalities and were atypical in location for metastases were interpreted as suggestive of a new primary malignant tumor. These image findings guide the biopsy for histopathology, immune-histochemistry to confirm the diagnosis.

Results

PET-positive findings suggestive of new primary malignant tumors were found in 30 (4.67%) of 644 patients. In 21 (3.26%) of 644 patients, these lesions were pathologically proven to be malignant (20 true positive and 1 case false negative). Proven sites were lung (5 cases), colorectal (5 cases), breast (2 case), liver (2 cases), head and neck (2 cases), anal (1 cases), gastric (1 case), lymphoma (1 case), esophagus (1 case), and prostate (1 case). In 9/30 (30%) patients suspected to have additional primary, PET was falsely positive. Biopsy was taken for histology and immune-histochemistry with follow-up record that confirms the diagnosis to validate the PET/CT findings.

Conclusions

With the use of 18-F FDG PET/CT image- guided biopsy, additional primary malignancies were detected in at least 3.26% of oncology patients; thus, patient cure is possible if such malignancies are treated promptly and aggressively.
Level of awareness of dentists about the role of physiotherapy in temporomandibular disorders: a pilot study in Riyadh, Saudi Arabia
Authors: Shaheen Afaf A. M. , Alhajri Hajar , Alrajeeb Noura , Almoammar Ruba , Alyousef Arwa , Buragadda Syamala , Melam Ganeswararao
Published: October 2020

Background

Physiotherapy (PT) is a distinguished developing profession. It has a crucial role in treating temporomandibular disorders (TMD) as an effective intervention to reduce pain and improve TMD symptoms. Not all dentists are aware of the importance of collaboration with physiotherapists (PTs).Therefore, this study aimed to assess the level of dentists’ awareness about the role of PT in treating TMD, identify dentists’ willingness to collaborate with PTs, and create collaboration awareness. This cross-sectional study included Saudi dentists in Riyadh. An online survey was used to assess dentist’s awareness and their readiness to collaborate with PTs.

Results

Out of 1500 dentists, only 162 participated in the survey. About 46.9% of dentists were aware that PT can treat TMD. Generally, there was lack of awareness about the benefits of PT among dentists (61.8%), and 59.9% was not aware that the evidence suggested that PT can improve TMD symptoms. Only 29% referred patients to PT. Upon the completion of the survey, almost all dentists (97.5%) were likely to refer patients with TMD to PT, and 90.7% of them showed interest to learn more about collaborating with PTs.

Conclusion

The study concluded that, although 46.9% of the dentists are aware about the role of PT in treating TMD, there is a lack of awareness about the benefits of PT among the majority of them. The study helped to extend the awareness of surveyed dentists about the collaboration and multidisciplinary approach.
Differential abilities to engage inaccessible chromatin diversify vertebrate HOX binding patterns
Authors: Bulajić Milica , Srivastava Divyanshi , Dasen Jeremy S. , Wichterle Hynek , Mahony Shaun , Mazzoni Esteban O.
Published: October 2020

While Hox genes encode for conserved transcription factors (TFs), they are further divided into anterior, central, and posterior groups based on their DNA-binding domain similarity. The posterior Hox group expanded in the deuterostome clade and patterns caudal and distal structures. We aim to address how similar HOX TFs diverge to induce different positional identities. We studied HOX TF DNA-binding and regulatory activity during an in vitro motor neuron differentiation system that recapitulates embryonic development. We find diversity in the genomic binding profiles of different HOX TFs, even among the posterior group paralogs that share similar DNA binding domains. These differences in genomic binding are explained by differing abilities to bind to previously inaccessible sites. For example, the posterior group HOXC9 has a greater ability to bind occluded sites than the posterior HOXC10, producing different binding patterns and driving differential gene expression programs. From these results, we propose that the differential abilities of posterior HOX TFs to bind to previously inaccessible chromatin drive patterning diversification.
Modeling the pedagogical support of self-development of adolescents in additional education based on a reflective-value approach
Authors: Ivanova Irina
Published: October 2020

Changes in the social and educational situation in the country actualized the development of subject-oriented models of pedagogical support for students, the search for effective ways to solve the aggravated problem of creating conditions for students' self-development. In modern school curricula, as well as in the system of additional education, there are practically no special classes on the construction and implementation of self-development projects by adolescents. The article proposes a model of pedagogical support for the self-development of adolescents in additional education, methodologically based on a reflective-value approach developed in the framework of the scientific school of M.I. Rozhkov, and technology-based on the development by adolescents of individual routes of self-development. The presented model can be considered as a pedagogical product and an educational resource that allows to solve a whole range of problems, based on the personal and social needs of both adolescents themselves and society as a whole. The implementation of the presented model involves the alignment of the educational process in further education with a focus on the self-development of students, while support is considered as a process of pedagogical interaction between teachers and students.

Acknowledgments: The reported study was funded by RFBR, project number 20-013-00616.
Monitoring with Limited Information
Authors: Iancu Dan Andrei , Trichakis Nikolaos , Yoon Do Young
Published: October 2020

We consider a system with an evolving state that can be stopped at any time by a decision maker (DM), yielding a state-dependent reward. The DM does not observe the state except for a limited number of monitoring times, which he must choose, in conjunction with a suitable stopping policy, to maximize his reward. Dealing with these types of stopping problems, which arise in a variety of applications from healthcare to finance, often requires excessive amounts of data for calibration purposes and prohibitive computational resources. To overcome these challenges, we propose a robust optimization approach, whereby adaptive uncertainty sets capture the information acquired through monitoring. We consider two versions of the problem—static and dynamic—depending on how the monitoring times are chosen. We show that, under certain conditions, the same worst-case reward is achievable under either static or dynamic monitoring. This allows recovering the optimal dynamic monitoring policy by resolving static versions of the problem. We discuss cases when the static problem becomes tractable and highlight conditions when monitoring at equidistant times is optimal. Lastly, we showcase our framework in the context of a healthcare problem (monitoring heart-transplant patients for cardiac allograft vasculopathy), where we design optimal monitoring policies that substantially improve over the status quo recommendations.

This paper was accepted by Chung Piaw Teo, optimization.
Optimal Stopping of Adaptive Dose-Finding Trials
Authors: Nasrollahzadeh Amir Ali , Khademi Amin
Published: October 2020

The primary objective of this paper is to develop computationally efficient methods for optimal stopping of an adaptive Phase II dose-finding clinical trial, where the decision maker may terminate the trial for efficacy or abandon it as a result of futility. We develop two solution methods and compare them in terms of computational time and several performance metrics such as the probability of correct stopping decision. One proposed method is an application of the one-step look-ahead policy to this problem. The second proposal builds a diffusion approximation to the state variable in the continuous regime and approximates the trial’s stopping time by optimal stopping of a diffusion process. The secondary objective of the paper is to compare these methods on different dose-response curves, particularly when the true dose-response curve has no significant advantage over a placebo. Our results, which include a real clinical trial case study, show that look-ahead policies perform poorly in terms of the probability of correct decision in this setting, whereas our diffusion approximation method provides robust solutions.
Inferring Sparse Preference Lists from Partial Information
Authors: Farias Vivek , Jagabathula Srikanth , Shah Devavrat
Published: October 2020

Probability distributions over rankings are crucial for the modeling and design of a wide range of practical systems. In this work, we pursue a nonparametric approach that seeks to learn a distribution over rankings (aka the ranking model) that is consistent with the observed data and has the sparsest possible support (i.e., the smallest number of rankings with nonzero probability mass). We focus on first-order marginal data, which comprise information on the probability that item i is ranked at position j, for all possible item and position pairs. The observed data may be noisy. Finding the sparsest approximation requires brute force search in the worst case. To address this issue, we restrict our search to, what we dub, the signature family, and show that the sparsest model within the signature family can be found computationally efficiently compared with the brute force approach. We then establish that the signature family provides good approximations to popular ranking model classes, such as the multinomial logit and the exponential family classes, with support size that is small relative to the dimension of the observed data. We test our methods on two data sets: the ranked election data set from the American Psychological Association and the preference ordering data on 10 different sushi varieties.
EU Medical Device Regulation 2017/745 versus US Food and Drug Administration approval of dermal filler products
Authors: Kelso Kate
Published: October 2020

Regulations to which dermal filler manufacturers must adhere so as to bring a product to market vary across the world. It is recognised that standards of the EU Medical Device Directive were inadequate, and, as a result of this, it is due to be replaced by the EU Medical Device Regulation (MDR) ( EU 2017 /745) on 26 May 2021. The EU CE mark will continue to be recognised in the UK until 30 June 2023. Typically, the more rigorous US Food and Drug Administration (FDA) process has been more trusted, but will this still be the case when the MDR comes into force? This piece contrasts and compares the new EU MDR and FDA regulation from an injector perspective.
Exploring the relationship between young people, body dissatisfaction and aesthetic procedures
Authors: Woodley Abigail
Published: October 2020

Physical appearance has long been documented to influence almost every aspect of an individual's life. The importance placed on physical attractiveness, combined with the pervasiveness of idealised bodies and appearances in Western societies, may result in dissatisfaction with appearance. Subsequently, individuals may explore methods and ways to alter their appearance in line with societal beauty ideals. An increasingly popular method of body modification is via aesthetic procedures. Thus, with the ever-rising exposure, popularity and affordability of such procedures, the associations between body image, aesthetic procedures and mental health are worthy of exploration.
The impact of the COVID-19 pandemic on holiday entitlements
Authors: Bernstein Adam
Published: October 2020

Holiday entitlement is likely the most valued benefits that an employee has. While employers frequently make mistakes in this area, COVID-19 has made the problem worse. Adam Bernstein details the changes that both employees and employers should be aware of
Undergraduate paramedics' understanding of mental health insight placements
Authors: Green Anita , Pound Amy
Published: October 2020

Aims:

Paramedics are often patients' first point of contact during mental health crises, and are increasingly responding to mental health emergencies. Paramedic training focuses predominantly on trauma and emergency physical healthcare rather than mental health difficulties. A UK-based pilot evaluation study aimed to find out whether providing mental health ‘insight’ placements for paramedic students in a local mental health trust would improve their understanding of patients with mental health issues, particularly from working alongside mental health practitioners.

Methods:

A pre- and post-experience questionnaire was used to elicit the students' understanding of mental health.

Conclusion:

The tentative conclusion is that the placement increased students' understanding of mental health services and mental health patients' needs, and they gained a greater understanding of mental health concepts. Being in direct contact with mental health colleagues in practice ensured that they could link mental health theory learned as part of their degree to their experience and gain insight into multiprofessional working.
Approaches to Cultivating Healthy Behaviours in Tertiary Students: Systemic Review
Authors: Bobrytska Valentyna I. , Reva Tatiana D. , Beseda Nataliia А. , Filippova Larysa V.
Published: October 2020

The purpose of the study was to identify the interventions used as approaches to cultivate healthy behaviours in undergraduate students and assess the effectiveness of those approaches. This was qualitative research. The design of the study was organised into three stages such as the search and selection stage, validation and assessment stage, and the interpretation stage. The originally designed Critical Appraisal Checklist was used by the research team members. The Triangular Assessment Method was used by the involved experts in pedagogics in the field of health education, psychology in the field of healthcare and health promotion, and experts in public health policy and healthy lifestyle management. The review provided a list of feasible approaches that can be combined to make the models that might increase the effectiveness of the process of cultivating healthy behaviours in tertiary students. These approaches were found to be the cross-domain solution seen as flexible. The specified approaches are easily combined with other ones. The use of these approaches in combination with the other approaches creates the models that can increase the effectiveness of the process of cultivating healthy behaviours in the students. The findings imply that healthy behaviour is a complex phenomenon that requires a consistent, multi-facet, and prolonged influence.
Thin-disk laser-pumped OPCPA system delivering 4.4 TW few-cycle pulses
Authors: Kretschmar Martin , Tuemmler Johannes , Schütte Bernd , Hoffmann Andreas , Senfftleben Björn , Mero Mark , Sauppe Mario , Rupp Daniela , Vrakking Marc J. J. , Will Ingo , Nagy Tamas
Published: October 2020

We present an optical parametric chirped pulse amplification (OPCPA) system delivering 4.4 TW pulses centered at 810 nm with a sub-9 fs duration and a carrier-envelope phase stability of 350 mrad. The OPCPA setup pumped by sub-10 ps pulses from two Yb:YAG thin-disk lasers at 100 Hz repetition rate is optimized for a high conversion-efficiency. The terawatt pulses of the OPCPA are utilized for generating intense extreme ultraviolet (XUV) pulses by high-order harmonic generation, achieving XUV pulse energies approaching the microjoule level.
Experiências, multipertencimentos e riscos de vida
Authors: Holanda Marinho Camila , Edwiges Andrade Lima Samara , Cavalcante Santos Vinicius
Published: October 2020

RESUMO: As últimas décadas apresentaram aumento exponencial de jovens vítimas de homicídios no Brasil, com isso, percebe-se a produção de um grupo formado por jovens que são filhos de jovens vítimas de homicídios. Nesse sentido, esse artigo tratará de reflexões sobre a memória e o esquecimento, as rotulações sociais e os multipertencimentos relacionados as identidades e experiências juvenis analisadas através da compreensão de trajetórias juvenis na contemporaneidade. Para tanto, foram realizadas entrevistas semi-diretivas e presenciais com três jovens que possuem experiências em instituições educativas e atividades laborais e que tiveram seus pais vítimas de homicídios na cidade de Fortaleza. PALAVRA-CHAVE: Juventudes. Homicídios. Rotulações. Experiências. Multipertencimentos.
Juventude, esporte e políticas públicas
Authors: Melo Ana Ruth , Franch Mónica
Published: October 2020

Este trabalho é um recorte de pesquisa de mestrado em sociologia desenvolvida pela primeira autora, com orientação da segunda. Foi realizada uma pesquisa etnográfica em um projeto social que visa proporcionar um espaço para que os jovens do bairro de Frei Damião, em Juazeiro do Norte- CE, possam, através da prática esportiva, disciplinar seus corpos. A prática esportiva em questão é o Jiu-jítsu, arte milenar muito difundida aqui no Brasil e no mundo, que a primeira autora pratica desde 2009. A inserção como participante do projeto permitiu aproximar categorias sociológicas como juventude, lazer e esporte, que foram centrais para pôr em diálogo, por um lado, as expectativas iniciais do projeto, alinhadas com a ideia de contenção a jovens “em situação de risco social”, e por outro lado, as motivações e experiências juvenis no cotidiano do projeto. Ficou evidente que, mais do que se aproximarem da prática do jiu-jítsu em função de uma suposta situação de risco, os jovens se apropriam desse espaço para praticarem uma arte marcial, se socializarem e estabelecerem vínculos afetivos. Metodologicamente, o trabalho teve inspiração na participação observante de Loïc Wacquant, com observações registradas em diário de campo e também realização de entrevistas.
Agências Estetizadas: Juventudes, Mobilizações e Ativismos em Angola
Authors: Marcon Frank
Published: October 2020

Meu objetivo com este artigo é analisar o contexto das mobilizações e do ativismo em Angola, em um período de emergência da geração digital e compreender o fenômeno da última década em que as formas de ativismo político passaram e ser expressos cada vez mais intensamente de forma estetizada. Pensando nas transformações ocorridas nas manifestações políticas em forma de protesto, desde 2011, analiso o caso de Angola, sobre o qual venho acompanhando as movimentações das juventudes através das redes sociais digitais, sites e blogs. Tenho notado que o visual, o sonoro, a escrita e as performances são linguagens ou agências de ação estética predominantes nas práticas de ativismos juvenis na última década, como no Brasil (Marcon, 2018). Isso significa dizer que entre os jovens as ações políticas são apresentadas de forma cada vez mais plástica e que as pessoas envolvidas nessas manifestações expressam um grande repertório criativo e comunicativo tanto local quanto global. O caso mais específico que trago aqui é o que ficou conhecido como 15+2 (quinze mais duas), quando durante o ano de 2015 alguns jovens foram presos por protestarem contra o presidente de Angola e tornaram a mobilização em torno do episódio da prisão um mote para expressão de manifestações e protestos, que ganharam grande repercussão em Angola e na comunidade internacional.
The effect of L-carnitine in Tris egg yolk-based diluent on the quality of Pasundan bull semen preserved in chilled condition
Authors: Darussalam I. , Arifiantini R. I. , Supriatna I. , Rasad R. S. D.
Published: October 2020

The study was conducted to investigatethe effect of L-Carnitine supplementation in Tris-eggyolk (TEY) diluents to optimize the quality of Pasundan bull liquid semen. Semen samples were collected from three Pasundan bulls (6 – 7 years old)usinganartificial vagina. Semen samples were evaluated macroscopically and microscopically, semen having ≥70% progressive motility, ≥500×106ml-1 sperm concentration and ≤ 20% sperm abnormalities were divided into 5 equal part. Each part  wasdiluted with TEYand supplemented with0 mM(control), 1 mM, 2 mM, 3 mM and 4 mM L-Carnitine. Liquidsemen was storedat5°C.Sperm motility was evaluated every 12 h  objectively using Computer Asissted Sperm Analysis (CASA) until progressive motilityreached 40%. The best diluent was demonstratedby progressive motility (PM)by TEY supplemented with 1 mM L-Carnitine(43.08±0.49%) that remained up to 108 h compared tothecontrol group (43.63±0.70%) that remained up to 72 h (P<0.05). In conclusion, 1 mM L-Carnitine in TEY was the best concentration for preservation of Pasundan bull semen stored in the liquid form.
Chemical characteristic, lactic acid bacteria population, and angiotensin converting enzyme inhibitory activity of traditional fermented beef ”cangkuk” by spontaneous fermentation with the addition of bamboo shoot
Authors: Mirdhayati Irdha , Zain Wieda Nurwidada Haritsah
Published: October 2020

This research was conducted to examine the chemical properties, lactic acid bacteria (LAB) populationand angiotensin converting enzyme (ACE) inhibitory activity of fermented beef meat with the addition of bamboo shoots. This research used factorial completely randomized design.Factor A was the preparation method of bamboo shoots: chopped, ground, and extracted. Factor B was the ratio of meat and bamboo shoots (B) which was1:0.75,1:1, 1:1,25ratios. The chemical properties observed were total protein, soluble protein, hydrolysisdegree, pHandtitratableacidity value. The results showed that bamboo shoot preparation methods by ground and extracted were able to reduce total protein, and pH value. The ratio of meat and bamboo shoot (1:0.75 and 1:1) wereable to decreasedtotal protein but increased total titratable acidity. The interaction of the factors A and factor B only occurredin increasing hydrolysisdegree. Both of two factors (A and B) couldnot significantly effect to the number of LAB.The ACE inhibitory activity ranged from 36.5 to 79.6%. It can be concluded that the preparation methods ofbamboo shoots by ground and 1: 0.75 and 1: 1ofbeef : bamboo shoot ratio couldincreasehydrolysis degree and had highest ACE inhibitory activity.
A quality improvement project for managing hypocalcemia after pediatric total thyroidectomy
Authors: Gonsalves Rob , Jamshidi Ramin , Newbern Dorothee , Shaibi Gabriel , Olson Micah , Chawla Reeti , Gnagi Sharon H. , Oatman Oliver J.
Published: October 2020

Objectives

Hypocalcemia following total thyroidectomy (TT) is relatively common. It may result in significant morbidity, prolonged hospital stay, and increased costs. Treatment with intravenous (IV) calcium gluconate may also carry significant risks. In pediatrics, management consensus guidelines are lacking.

Methods

At Phoenix Children’s Hospital, a team of pediatric endocrinologists, surgeons and otolaryngologists developed a clinical pathway for patients undergoing TT. It was a Quality Improvement (QI) project with the primary aim of decreasing IV calcium gluconate use from a baseline of 68% to less than 40% over 15 months. Secondary aims included reducing hypocalcemia and length of hospitalization. Interventions included sending weekly pathway reminder emails, starting pre-operative calcium, and pathway implementation into the electronic health record.

Results

Twenty-seven patients underwent TT over 15 months. IV calcium gluconate use dropped to 48%. Hypocalcemia and length of hospitalization were 96% and 52.7 h (range 21.1–115.7) respectively. Pathway adherence improved after targeted interventions. Eleven (73%) of the 15 patients whose post-operative parathyroid hormone (PTH) nadir was below 15 pg/mL required IV calcium gluconate vs. two (17%) out of 12 with levels above this threshold.

Conclusions

Standardizing care allowed for objective outcome analysis. We learned that post-operative serum PTH level was the main risk factor for requiring IV calcium gluconate. Implementing the pathway as a QI project allows for revisions based on outcomes, ultimately resulting in a pathway that best utilizes our infrastructure to optimize care. Other pediatric institutions may face similar challenges and can potentially learn from our experience.
Generalized Picone inequalities and their applications to (p,q)-Laplace equations
Authors: Bobkov Vladimir , Tanaka Mieko
Published: October 2020

We obtain a generalization of the Picone inequality which, in combination with the classical Picone inequality, appears to be useful for problems with the

(
p
,
q
)

(p,q)

-Laplace-type operators. With its help, as well as with the help of several other known generalized Picone inequalities, we provide some nontrivial facts on the existence and nonexistence of positive solutions to the zero Dirichlet problem for the equation

−

Δ

p

u
−

Δ

q

u
=

f

μ

(
x
,
u
,
∇
u
)

-\hspace{-0.25em}{\text{Δ}}_{p}u-{\text{Δ}}_{q}u={f}_{\mu }(x,u,\nabla u)

in a bounded domain

Ω

⊂

ℝ

N

\text{Ω}\hspace{0.25em}\subset {{\mathbb{R}}}^{N}

under certain assumptions on the nonlinearity and with a special attention to the resonance case

f

μ

(
x
,
u
,
∇
u
)
=

λ

1

(
p
)
|
u

|

p
−
2

u
+
μ
|
u

|

q
−
2

u

{f}_{\mu }(x,u,\nabla u)={\lambda }_{1}(p)|u{|}^{p-2}u+\mu |u{|}^{q-2}u

, where

λ

1

(
p
)

{\lambda }_{1}(p)

is the first eigenvalue of the p-Laplacian.
Cross-sections of 45Sc(n, 2n)44m,gSc reaction from the reaction threshold to 20 MeV
Authors: Luo J. , Liu R. , Jiang L. , Liu Z. , Sun G. , Ge S.
Published: October 2020

Cross sections of 45Sc(n, 2n)44m,g Sc reactions and their isomeric cross section ratios σ
m
/σ
g have been measured at three neutron energies between 13.5 and 14.8 MeV using the activation technique. The pure cross section of the groundstate was then obtained by utilizing the absolute cross section of the metastable state and analysis methods of residual nuclear decay. The monoenergetic neutron beam was produced via the 3H(d, n)4He reaction. The cross sections were also estimated with the TALYS-1.2 nuclear model code using different level density options, at neutron energies varying from the reaction threshold to 20 MeV. Results are also discussed and compared with some corresponding values found in the literature.
The Hawaii Promotion Committee and the Appropriation of Surfing
Authors: Moser Patrick
Published: October 2020

The advent of digital newspapers is providing critical historical information for subjects like surfing that have traditionally had so few primary sources available to researchers. A review of newspapers from the early twentieth century reveals important new evidence that the Hawaii Promotion Committee (HPC) helped support the growth of surfing by coordinating a transpacific marketing campaign to highlight the sport for the sake of boosting tourism. However, because the HPC and the newspapers in which it published its weekly reports represented arms of the colonial powers, much of that new information must be understood in the broader context of how the local Caucasian or haole population used the newspapers to promote their own imperial vision of surfing while often ignoring or suppressing Native Hawaiian voices that represented a critical counternarrative. For their part, Native Hawaiians actively resisted the racist and pro-territorial propaganda by publishing their own newspapers and by directly competing against haole in and around the surf.
“From Sagebrush to Symphony”
Authors: Thabet Andrea
Published: October 2020

This article explores the founding of the Hollywood Bowl and the multiple visions of its founding generation, tracing the cultural negotiations they engaged in between 1918 and 1926. These aims included disseminating high culture to ordinary citizens, democratizing access to music, providing spiritual uplift, unifying Hollywood’s diverse populace, and offering legitimacy to Hollywood as an emerging symbol of the U.S. film industry. By 1926, the Hollywood Bowl that emerged from a contentious planning process reflected aspects of all of the founders’ goals, but did not entirely fulfill those of any one of them. I argue that, despite their disagreements, the Bowl’s founders believed that their collective cultural enterprise had the potential to encourage a sense of cohesion and community among Hollywood’s—and more generally Los Angeles’s—inhabitants. The Hollywood Bowl was the first of many large-scale efforts to give culture permanence in Los Angeles, and its success helped redefine its urban identity by replacing negative images of the region with a growing reputation as a noteworthy cultural metropolis.
Employee Behavioral Commitment of BLU UPTD Trans Semarang
Authors: Winarsih Puji , Martono S
Published: October 2020

The purpose of this study was to determine the effect of Work Life Balance, Job Satisfaction, Engagement, and Motivation on the Commitment of BLU UPTD Trans Semarang Employees. The population in this study were BLU UPTD Trans Semarang employees totaling 187 employees. The sample used was 128 employees. The sampling technique in this study used probability sampling, where the sampling used was proportionate random sampling. The results showed that work life balance had a positive and significant effect on employee commitment, job satisfaction had a positive and significant effect on employee commitment, engagement had a positive and significant effect on employee commitment, and motivation had a positive and significant effect on employee commitment. Can be proven on the results of multiple linear regression tests that is the entire result sig <from 0.05. This means that all hypotheses are accepted. Suggestions from this research are to be able to improve all indicators of work life balance, job satisfaction, engagement and motivation so that employee commitment is getting better and more improved.
Do Green Practices in the Hotel Attract Customer to Revisit? A Study in a Green Hotel in Surakarta
Authors: Astuti Septin Puji , Ermawati Yuni
Published: October 2020

The Ministry of Environment of the Republic of Indonesia encourages sustainable tourism and hospitality industry to achieve green hotel and green tourism in 2020. Rumah Turi as one of hotel destinations in the middle of Surakarta has provided green practice and facilities in the hotel. This study intends to investigate the determinant factors of revisit intention to Rumah Turi. This study is conducted to hotel customers who have visited Rumah Turi. Sample of this study is 131 customers of Rumah Turi from various cities in Indonesia. Five independent variables, i.e. green practice, service quality, facility, price and location, are applied in this study to be identified of their influence to revisit intention. By implementing linear multiple regression analysis, it is found that this study unable to make evidence that service quality and price influence customer to have the intention to revisit Rumah Turi. However, by using moderated multiple regression analysis, this study has proven three models of the determinant factors of revisit intention. The first model (Model 3) is, the moderator of service quality to facility and the moderator of price to location, in addition to green practice have significantly influenced revisit intention. Second model is Model 4, where green service and service quality are the moderators of facility and price as the moderator of location have significantly influenced to revisit intention. Third model is Model 5, where service quality, price and green practice are the moderators of facility altogether with location have significantly influenced revisit intention.
The Effect of Mediation Work Engagement to Procedural Justice and Organizational Learning on the Innovative Behavior
Authors: Sari Fara Kartika , Palupiningdyah Palupiningdyah
Published: October 2020

The purpose of this study was to determine the effect of procedural fairness and organization learning on innovative behavior through work engagement. The population in this study were all batik craftsmen in Semarang City IKM Batik, totaling 165 people. Based on this population 117 respondents were taken by proportional random sampling technique. Data collection in this study used a questionnaire, observation and interviews. The analytical method used is SPSS IBM Statistics 25. The results of this study indicate that procedural justice has positive and significant influence on innovative behavior, organizational learning can have a positive and significant effect on innovative behavior and work engagement, work engagement can have a positive and significant effect on innovative behavior, then work engagement can mediate the positive influence of procedural justice and organizational learning on innovative behavior. The conclusion of this research is procedural fairness,organizational learning and work engagemEnt can increase innovative behavior. Furthermore work attachment can mediate the influence of procedural fairness and organization learning on innovative behavior. Suggestions for IKM batik management are to have emotional closeness such as the availability of leaders to listen to the complaints of employees, the existence of activities such as workshops and exhibitions on a regular basis to trigger increased knowledge so that it is easier to create new ideas.
Government Ownership and Dividend Payment Policy
Authors: Putri Pavita Bayu , Yulianto Arief
Published: October 2020

The purpose of this study to examine and analyze differences in the average policy of dividend payments with government ownership in companies listed on the Indonesia Stock Exchange in period 2008-2017. Previous research still shows differences in research results or inconsistent results between one study and another. The results showed that the average dividend payment policy carried out by the government was higher than companies that did not have government ownership. This is considered as government ownership, so the amount of dividends distributed will increase. Based on the results of this study it can be concluded that government ownership provides an average higher dividend payment policy than non-government ownership. Suggestions for company management, in making dividend payment policies, the company should always consider the interests of the company’s owners. Investors should pay attention to factors outside the economy in investing. For further researchers, it can be used as an additional reference and research can be done one by one sector.
Exposure of CSR Dimension for Business Development: Case Study in Industrial Estate
Authors: Sarjana Sri , Khayati Nur , Warini Lis , Praswiyati Praswiyati
Published: October 2020

This study aims to find out how contribution of companies in industrial estate has an active involvement in corporate social responsibility (CSR) programs. In addition, the study also encourages companies to develop business in industrial estates, especially for industrial manufacturers in various business backgrounds through strengthening of the company’s active involvement in corporate social responsibility programs. Research has been conducted data collection and testing for the management in industrial estate at West Java, Indonesia. The sample selection was collected by using random sampling. Observations were made in time horizon or cross-sectional. Data were tested using structural equation modeling. The results concluded that the company has not been optimally involved in corporate social responsibility program. This can be seen from the lack of corporate contribution related to the role of company to engage directly on corporate social responsibility that can be felt and utilized by surrounding community to develop resources around it. The research expects for manufacturing industries in industrial estates to increase active involvement in corporate social responsibility programs as they positively impact business development in the future.
Preventing Photomorbidity in Long-Term Multi-color Fluorescence Imaging of Saccharomyces cerevisiae and S. pombe
Authors: Schmidt Gregor W , Cuny Andreas P , Rudolf Fabian
Published: October 2020

Time-lapse imaging of live cells using multiple fluorescent reporters is an essential tool to study molecular processes in single cells. However, exposure to even moderate doses of visible excitation light can disturb cellular physiology and alter the quantitative behavior of the cells under study. Here, we set out to develop guidelines to avoid the confounding effects of excitation light in multi-color long-term imaging. We use widefield fluorescence microscopy to measure the effect of the administered excitation light on growth rate (here called photomorbidity) in yeast. We find that photomorbidity is determined by the cumulative light dose at each wavelength, but independent of the way excitation light is applied. Importantly, photomorbidity possesses a threshold light dose below which no effect is detectable (NOEL). We found, that the suitability of fluorescent proteins for live-cell imaging at the respective excitation light NOEL is equally determined by the cellular autofluorescence and the fluorescent protein brightness. Last, we show that photomorbidity of multiple wavelengths is additive and imaging conditions absent of photomorbidity can be predicted. Our findings enable researchers to find imaging conditions with minimal impact on physiology and can provide framework for how to approach photomorbidity in other organisms.