bluuebunny/crossref_metadata_2025 huggingface dataset:
Traditional and Online Bullying Victimization Among School-going Adolescents: The Role of Sociodemographic Factors
Authors: Suresh Sruthi , R Vijaya , Alfonso Thaddeus , Rajan Santhosh
Published: November 2024

Background:

Bullying in school is a vital issue as researchers increasingly find that it can be detrimental to students’ well-being and academic excellence. From an ecological systems theory perspective, examining school bullying reveals that numerous psychosocial factors influence student behavior. Hence, the present study aims to investigate the role of sociodemographics—at the individual (age, gender), microsystem and mesosystem (grade level, school type), exosystem (region), macrosystem (socioeconomic status), and chronosystem (shift from traditional to virtual classroom during COVID-19) levels—in the victimization of traditional and online bullying.

Methods:

After obtaining ethical clearance, an online survey form was deployed to collect sociodemographic information and assess traditional and online bullying victimization among 120 school-going adolescents from the Southern regions of India.

Results:

A linear regression analysis showed age and region (urban and rural) predicting traditional and online victimization, respectively. Other sociodemographic factors of gender, school type, and grade level did not predict either victimization type.

Conclusions:

Sociodemographic factors play a significant role in the victimization experiences of students both in traditional and online.
Assessment of Knowledge and Practices of Nursing Personnel While Caring of Brain Dead Patients Potential for Organ Donation
Authors: Sharma Durgesh , Singh Neena Vir , Kaur Sukhpal , Kaur Mandeep , Jain Kajal
Published: November 2024

Introduction

Organ donation and transplantation is a life-saving procedure for patients with end-stage organ failure, but it depends on the availability of donor organs. Nurses play a major role to provide care to brain-dead patient potential for organ donation and efficient care to increase the organ’s survival. For years many efforts have been made to create awareness in public regarding organ donation but donors are still very less than demand. Most of the recipients are waiting for organs for more than 6–8 years and many died because of the paucity of donors. Hence, knowledge of nursing personnel is extremely important to the success of organ donation.

Objective

To assess the knowledge and practices of nursing personnel while caring of brain-dead patients potential for organ donation.

Methodology

A descriptive research design was adopted to carry out the study. The study was conducted among 30 nursing personnel caring for brain-dead patients from the automatic tube compensation ICU and various units of Nehru Hospital, PGIMER, Chandigarh. Nurses were given questionnaires to fill, including a sociodemographic data sheet and a knowledge questionnaire. The practices of caring for brain-dead patients were observed by using an observation checklist, and a total of 30 observations were made.

Results

The findings of the study revealed that 50% of nursing personnel had good knowledge about the care of brain-dead patients, 32% had average knowledge, whereas 18% had poor knowledge. There were 42 steps/items of practice regarding care of a brain dead patient. Around one third (38%) of the steps were followed by the participants, some of them followed 57% of the steps.

Conclusion

Only half of the nursing personnel were possessing good knowledge about the care of brain-dead patients and less than half were doing good practices about the care of brain-dead patients; hence, there is a need to educate the nursing personnel regarding caring of brain-dead patients.
Endocervical Adenocarcinoma With Micropapillary Component, a Distinct Histological Subtype Associated With Aggressive Behavior and Poor Prognosis: A Clinicopathologic Study of 10 Patients
Authors: Wang Su , Huang Xianfeng , Zhou Xin , Chen Lili , Zhang Huijuan , Chen Hao , Zhou Feng
Published: November 2024

Objective. Endocervical adenocarcinoma (ECA) with a micropapillary component is considered to be associated with aggressive behavior and poor prognosis. So far, only limited studies investigated this histological subtype of ECA in the literature. In this study, we present a clinicopathological analysis of 10 such tumors. Methods. We retrieved ten ECAs with a micropapillary component between January 2014 and July 2023 and analyzed their clinicopathologic features. Results. At diagnosis, nine tumors (90%) were of advanced clinical stage (FIGO stage ≥ IIA), nine tumors (90%) exhibited deep stromal invasion (≥2/3 of the cervix), and three tumors (30%) showed parametrial involvement. Lymphovascular invasion was evident in all tumors (100%), and lymph node metastasis was found in eight tumors (80%). Among the 10 patients, six were alive without disease (60%), one had a recurrent/later metastatic tumor (10%), and three died from the disease (30%). Furthermore, eight tumors were positive for PD-L1 expression (80%), while only one tumor showed HER2 overexpression (10%), and one tumor exhibited p53 mutant-type staining (10%). Conclusion. Endocervical adenocarcinomas with micropapillary components are associated with aggressive clinical behavior and a poor prognosis, which can be found in various conventional histological types of ECAs regardless of the HPV status. The high prevalence of PD-L1 expression suggests that patients with micropapillary ECAs may be good candidates for PD-L1 inhibitor treatment.
Comparative Study on the Application Effects of Optimized Frozen Section Procedure in Oral Cancer Surgery
Authors: Yang Junjun , Yang Yang
Published: November 2024

Objective. To investigate the application effects of optimizing the frozen section procedure in oral cancer surgery. Methods. A total of 45 oral cancer patients undergoing surgery were selected as the control group, operated from January 2020 to May 2021, without optimization of the frozen section procedure. Another 45 oral cancer patients undergoing surgery were selected as the experimental group, operated from June 2021 to December 2022, with the optimized frozen section procedure. The differences in the excellent rate of sections, the preparation time, the frozen report time and the accuracy rate between the two groups were compared. Results. In terms of the excellent rate of sections, the optimized procedure group was (44/45) 97.8%, which was higher than the conventional group (40/45) 88.9%; the preparation time and frozen report time in the optimized procedure group were (9.2 ± 0.7) min, and (26.4 ± 2.2) min, respectively, both shorter than those in the conventional group were (12.3 ± 1.3) min, and (31.8 ± 2.7) min, ( p < 0.05); the accuracy rate of the frozen report, the optimized procedure group was (43/45) 95.6%, which was higher than the conventional group (40/45) 88.9%. Conclusion. Optimizing the frozen section procedure in oral cancer surgery can achieve desirable results, conducive to improving slide quality, reducing preparation time, and overall frozen report time. It is worthy of promotion.
Why Science Should Have a Female Face: Female Experts Increase Liking, Competence, and Trust in Science
Authors: Hubner Austin Y. , Bullock Olivia M.
Published: November 2024

Historically, female experts have been perceived as less competent but more likable than their male counterparts. This experimental study ( n = 958) examines the intricate relationship between likability, competence, scientist gender, participant gender, and trust scientific expertise. Our results illuminated the mediating role of likability in shaping perceptions of competence, where heightened likability positively influenced perceived competence. Moreover, exposure to science messages from female scientists significantly increased trust in science through a serial mediation model. Notably, participants liked the scientist of the opposite gender; thus we did not observe a gender affinity effect.
Exploring the Relational Commitments of Negotiating Narrative Accounts in Narrative Inquiry
Authors: Dubnewick Michael
Published: November 2024

The purpose of this article is to discuss and make clear the methodological commitments of co-composing and negotiating narrative accounts in narrative inquiry. The negotiation of interim texts is a widely used practice across a range of methodologies and paradigms (i.e., member checking, member validation, member reflections, and narrative accounting), yet there is little discussion on the varied philosophical underpinnings that shape the meaning and purpose of negotiating interim texts with participants. By drawing on the authors experiences of negotiating narrative accounts across projects this article will clarify the relational commitments that underpin this aspect of narrative inquiry as a move toward mutuality, co-composition, friendship, and ongoing attentiveness ordinary lived experience.
Hierarchies of Actualization
Authors: Lewis-Hunstiger Marty
Published: November 2024

The concept of transforming power over to power with, the theme of this issue of Creative Nursing, comes from Riane Eisler's cultural transformation theory describing a continuum of domination and partnership along which cultures orient themselves. Hierarchies are important organizing principles in many systems; it is not their presence that is inhumane, but how they function. Domination systems display authoritarian rule in both the family and the state or tribe, with strict hierarchies of domination, and narratives that normalize domination and present the violence that maintains it as inevitable. Partnership systems are characterized by egalitarian structures in both the family and state or tribe, with hierarchies of actualization in which power is used to empower others rather than disempower, low levels of sanctioned violence (since it is not needed to maintain power), and narratives depicting mutual respect, accountability, and benefit as natural. All the articles in this issue of Creative Nursing depict empowerment: of patients, parents and other family members, foster parents, children from preschool age to near adulthood, providers of direct patient care at many levels in many areas, nurses seeking to publish their knowledge, and all people who seek to use language that demonstrates respect and value for all people while acknowledging the diverse cultures in which we abide.
Hounsfield unit values are useful for predicting early outcomes after acetabular fractures: a retrospective study
Authors: Ukai Taku , Tamaki Miyu , Sato Masato , Watanabe Masahiko
Published: November 2024

Background:

Acetabular fractures are among the most challenging orthopaedic fractures, and a high total hip arthroplasty (THA) conversion rate has been reported in older patients with acetabular fractures. Bone quality is a poor prognostic factor after acetabular fracture fixation and has been assessed using computed tomography (CT). However, the relationship between Hounsfield unit (HU) values measured using CT and early acetabular fracture outcomes remains unknown. This study aimed to elucidate the effect of HUs on early acetabular fracture outcomes.

Methods:

50 consecutive patients who underwent open reduction and internal fixation for acetabular fractures were included. The mean follow-up duration was 24 months. 27 hips had elementary fractures and 23 had associated fractures. The reduction quality assessed using CT was as follows: anatomical, 13 hips; imperfect, 10 hips; and poor, 27 hips. Secondary hip osteoarthritis was observed in 5 patients (10%), and the surgery was converted to THA in 1 patient (2%). The HU values of the fifth vertebral body and the unaffected side of the femoral head were measured. The fracture type, radiological secondary hip osteoarthritis, conversion to THA, and postoperative displacement gap were recorded.

Results:

The unaffected femoral head HU values in elementary fractures (250.5 ± 50.5) were significantly higher than those in associated fractures (221.5 ± 48) ( p  < 0.047). The HU values of the fifth vertebral body and the unaffected femoral head were significantly correlated with the postoperative residual displacement gap and were significantly lower in those with secondary osteoarthritis than in those without it. The cut-off value for predicting early osteoarthritic change after an acetabular fracture was approximately 180.

Conclusions:

The HU values were correlated with the fracture type, postoperative displacement gap, and early osteoarthritic change after acetabular fractures and are clinically useful prognostic factors for early acetabular fracture outcomes.
An Observational Study of Regulatory Violations Related to Online Tobacco Product Marketing and Retailer Responses to US FDA Warning Letters
Authors: Apollonio Dorie E. , Dennehy Cathi E. , Tsourounis Candy , Wakefield Tanner
Published: November 2024

Background

Marketing of flavored tobacco products has drawn concern because they are used disproportionately by young people. Online retailers have marketed e-cigarette liquids and devices to minors despite knowing it is illegal. The onset of the COVID-19 pandemic resulted in substantial increases in online purchasing, however, there has been limited study of possible shifts in online tobacco product marketing associated with this change.

Objectives

We sought to identify types of tobacco regulatory violations in 2021-2022, marketing claims made by retailers, the extent to which retailers had processes in place to deter minors from browsing websites, and the types of flavors promoted.

Design and Methods

Our observational study was based on an initial sample of 100 tobacco retailers that had received FDA Warning Letters in 2020-2021. Using methods validated in previous research, we coded the letters for retailer information, violation type, and for retailers with an online presence, the types of products sold, and their marketing claims.

Results

Most retailers with violations were in the US South (48%), 65% had an online presence at the time of analysis, and 53% had a website that offered online product sales. The most common type of violation was the sale of new tobacco products without required marketing authorization (83%). For the retailers in the sample with active websites, 42% were still selling a product that the FDA had indicated was marketed unlawfully. Among these retailers with active websites, 32% did not have processes in place to deter access by minors. Advertised flavors focused on food (eg, mango, honey) and concepts (eg, “love”, “classic”).

Conclusions

Online retailers appeared less likely to remediate tobacco product violations identified by the FDA after the onset of the COVID-19 pandemic than before it, and few websites had strong processes in place that would deter youth browsing.
Patients’ preferences for virtual outpatient consultations and health care professionals’ assessment of suitability for their patients: A single-centre survey
Authors: Schultz Anders Nikolai Ørsted , Honnens Søs , Bauer Eithne Hayes , Söderberg Kathrin , Kidholm Kristian , Christensen Robin , Kampmann Jan Dominik , Christiansen Anders , Brandt Frans
Published: November 2024

Objectives

To explore patients’ preferences regarding virtual consultations (via telephone or video) and to explore healthcare professionals’ assessment of whether virtual consultations can maintain the same clinical quality as in-person consultations for outpatient care.

Methods

A cross-sectional survey was conducted among patients with an in-person consultation at the outpatient clinic for internal medicine and among healthcare professionals who treated the patients. The prevalence of preference was determined using descriptive statistics based on cross-tabulated frequencies. Percentages are presented with 95% confidence intervals (95%CI).

Results

In total, 218 patients (response rate 67%) completed the questionnaire; 79 patients (36%) preferred a virtual consultation (95%CI: 30%–43%); telephones were the most popular and preferred by 72 patients (33%; 95%CI: 27%–39%) followed by video preferred by 54 patients (25%; 95%CI: 19%–31%). Regarding contextual factors, male gender and previous experiences with telephone or video consultations were statistically significant predictors in favour of virtual consultations. Healthcare professionals estimated that 58 consultations (21%; 95%CI: 17%–26%) could have been conducted virtually with the same professional and clinical quality as the current in-person consultations.

Conclusions

Current practice does not fully align with patient preferences for virtual visits in internal medicine outpatient clinics. Patients should be given the choice of virtual consultations whenever they are deemed professionally and clinically possible to enhance patient autonomy and satisfaction, while being mindful of speciality-specific considerations.
A mileage correction method of pipeline inertial measurement for dam internal deformation monitoring
Authors: Lv Shiwang , Li Qingquan , Yin Yu , Chen Xiaopan , Yu Jianwei , Chang Shiju , Liu Fuqiang , Zhao Jie , Ru Songnan , Chen Zhipeng
Published: November 2024

Internal deformation monitoring is of great significance to the safe operation and maintenance of dams. Some scholars have carried out dam internal deformation monitoring by pipeline inertial measurement with a pipeline measurement robot, which has improved the monitoring accuracy and efficiency considerably, compared with the traditional monitoring methods. However, there are still shortcomings in this method. Because the odometer on the pipeline measurement robot will slip or slide, resulting in errors in the mileage of the multiple measurement routes, which hinders the development of the accuracy of pipeline inertial measurement. This paper proposes a mileage correction method based on junction detection to improve the accuracy of pipeline inertial measurement for better dam internal deformation monitoring. The mileage correction method establishes a reference model of pipeline junction location, detects the locations of pipeline junction welds on the measurement routes using two k-mean clustering, and corrects the odometer data based on the difference between the detected and reference locations. We evaluate the enhancement of this mileage correction method on the internal accuracy and deviation values compared with other method for pipeline inertial measurement. The proposed method is validated using measured data from the internal pipeline of Tianchi Dam. The results show that compared with the results directly fused without detection–correction, the method proposed in this paper reduces the root-mean-square error of the results by an average of 30.30% and improves the deviation compared with the reference deformation by an average of 2.3 mm. Therefore, the method has good results and practical applications.
Damage evaluation in plain-woven CFRP plate with circular hole under cyclic tensile loading using electrical impedance tomography
Authors: Heinzlmeier Lukas , Wagner Jonas , Kimpfbeck Daniel , Sieberer Stefan , Kralovec Christoph , Schagerl Martin
Published: November 2024

Understanding and predicting damage progression within thin plain-woven carbon fiber-reinforced polymer (CFRP) components is an essential issue for scheduling maintenance intervals and structural inspections and typically requires extensive test series. However, uncertainties always remain and result in conservative design and unnecessary downtimes due to the repeated inspections of a healthy structure. Structural health monitoring (SHM) can be used to reduce these uncertainties, as it allows one to evaluate the condition of a mechanical structure during operation. Numerous SHM methods have been developed, which achieve different levels of damage identification but are often investigated at small coupons with nonrealistic structural damages and loading conditions on both structure and sensor. The present research investigates electrical impedance tomography (EIT) featuring an elastoresistive thin-film sensor to evaluate damage that propagates from a circular hole in a large plate under cyclic tensile–tensile multiblock loading. Applied fatigue loads were increased multiple times up to a total number of two million cycles. During the loading, damage initiated at the hole and continuously propagated into the plate. Repeated EIT evaluations of the applied sensor and validating evaluations by means of digital image correlation clearly revealed the robustness of the hardware and the potential of the SHM method for damage evaluation of plain-woven CFRP components.
From the Murky Depths to the Brain: A Tale of a Glowing Protein That Became the Core of a Seizure-Suppressing Molecular Machinery
Authors: Eyal Sara
Published: November 2024

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The Power of Delphi and Advocacy: Consensus in SCN8A-Related Epilepsy and Neurodevelopmental Disorders
Authors: Joshi Charuta
Published: November 2024

[Box: see text]
Aggravated Uncertainties, Researcher Resilience, and Ambiguous Positionality Doing Fieldwork in China Amid COVID-19 Pandemic
Authors: Zhao Hongsheng , Bao Wenwei
Published: November 2024

This paper aims to answer the research questions of ‘How did COVID-19 aggravate the uncertainties in geographical fieldwork, and how could the researchers cope with the challenges?’ Referring to the case study method in scrutinising a fieldwork case that has been conducted by the researchers on Chinese rural-urban migrants in 2020–2021, this research explores the multi-layers of increased uncertainties amid COVID-19. It reveals that that recent COVID-19 pandemic and its knocking-on effects have profound impacts on fieldwork in Chinese context: not only aggravating the scale of uncertainties, but also extending the uncertainties through several dimensions, including harder access to the field, more severe surveillance, which lead to fragile trust between informants and field researcher. The article further posits the significance of researcher’s resilience and reflectivity in fieldwork to address the emerging challenges, proposing adjusted positionality for researchers under the similar context of doing fieldwork in China amid COVID-19 pandemic.
Conceptualising nursing theory and practice within a local cultural and professional context: a methodological example to inform theory development
Authors: Pagnucci Nicola , Tolotti Angela , Valcarenghi Dario , Carnevale Franco , Sasso Loredana , Bagnasco Annamaria
Published: November 2024

Background:

Nursing theories are crucial toward orienting the development of knowledge and practice. However, there is a persistent debate in the literature regarding the gap between theory and practice. Theories and conceptual models developed in Anglo-Saxon countries are often proposed within diverse educational and clinical contexts in other countries, generating challenges in their application in practice.

Aim:

This study aimed to develop and propose a methodology to promote the advancement of nursing theorising, considering local cultural and professional contexts.

Methods:

This analysis was conducted within Italy, which served as a local cultural and professional context exemplar for this investigation. A Scoping Review was used to map local nursing knowledge related to nursing practice. Fawcett’s metaparadigm was used as a general orienting frame for the literature analysis.

Results:

In light of the analysis conducted, the four disciplinary concepts related to the local (Italian) cultural and professional context were described (person, environment, health, nursing).

Conclusion:

This investigation aimed to present an example of how an inductive reflective approach can be used as a way to map nursing practice and define disciplinary concepts that can guide conceptual/theory development. The knowledge that was generated can orient initiatives to promote local nursing theory development.
Spontaneous transfer of relational category structures between category learning tasks: A novel approach to measure analogical transfer
Authors: Snoddy Sean , Kurtz Kenneth J
Published: November 2024

The ability to spontaneously access knowledge of relational concepts acquired in one domain and apply it to a novel domain has traditionally been explored in the analogy literature via the problem-solving paradigm. In the present work, we propose a novel procedure based on categorisation as a complementary approach to assess spontaneous analogical transfer—using one category learning task to enhance learning of the same underlying category structures in another domain. In Experiment 1, we demonstrate larger improvements in classification performance across blocks of training in a target category learning task among participants that underwent a base category learning task relative to a separate group of participants learning the target category structures for the first time, thus providing evidence for spontaneous transfer of the category structures. In Experiment 2, we demonstrate similar evidence of spontaneous transfer for participants that underwent a comparison-based base category learning task under a more rigorous context shift between the base and target category learning tasks. Additional exploratory analyses across both experiments showcase ways in which this paradigm can be used to answer questions regarding the analogical transfer of relational category structures and generate promising paths for future work.
Moral education and social transformation: The Jesus model
Authors: Campbell Erica Christine
Published: November 2024

Educational institutions are expected to play a significant role in preparing people to function well in society. Although critical thinking and problem-solving skills are necessary, people also need to have a social conscience. Educators should, therefore, pay more attention to moral education. Jesus Christ developed and implemented a moral education curriculum and there is a record of that in the New Testament. An examination of it reveals that Jesus built his training around social issues and that he employed a strategy that bears some similarity to Mezirow’s transformation learning theory: his audience was adult and he called upon his students to process disorienting dilemmas, drawing them to reflect critically on assumptions from which was to come mindset change and, ultimately, behavior change. Whereas Mezirow focused on individual experiences and individual transformation, Jesus planned to impact the world—Jewish society and far beyond it—through bands of disciples working in concert. Educators who seek to contribute to social transformation through moral education should consider following the Jesus model which is outlined in this paper.
Can Digital Technology Revolutionize Continuous Education in Diabetes Care?
Authors: Ait-Aissa Nadia
Published: November 2024

Rapid technological advancements, such as artificial intelligence, wearable technologies, and telehealth with remote monitoring, are transforming continuous education for health care providers (HCPs) in diabetes management. These technologies improve patient care and necessitate innovative educational approaches to prepare HCPs for clinical integration. Digital education offers real-time, scalable, and cost-effective solutions, especially in areas with health care workforce shortages. However, the effect of digital education on HCPs’ knowledge, skills, attitudes, and patient outcomes remains under-researched and necessitates further study. As technologies advance, achieving precision in diabetes continuous education becomes feasible. The 2024 ADA Standards of Care emphasize early adoption of advanced technologies and proficiency among HCPs. This commentary explores transformative trends, discussing limitations and proposing solutions to revolutionize continuous education in diabetes care.
Focal segmental glomerulosclerosis (FSGS) in pregnancy: The case of a 27-year-old woman with nephrotic syndrome at 22 weeks of gestation
Authors: Wang Lucy , Viswanathan Seethalakshmi , Fischer Eddy , Bose Bhadran
Published: November 2024

Nephrotic syndrome (NS) in pregnancy has been associated with poor fetal outcomes. Focal segmental glomerulosclerosis (FSGS) is one of the common causes of NS and can be primary or secondary. However, there are few case reports of FSGS diagnosed in the peripartum period and the approaches to management. We report the case of a 27-year-old gravida 2 para 1 Caucasian woman diagnosed with NS at 22 weeks of gestation. Her serum creatinine was 46 µmol/L (0.48 mg/dL), serum albumin 14 g/L (1.4 g/dL) and 24-h urinary protein 9.79 g/day with no haematuria. Serology was negative for lupus, phospholipase A2 receptor antibody, hepatitis and HIV. Paraprotein screening was also negative. The patient declined a renal biopsy. Differential diagnoses at this stage included minimal change disease and FSGS. Six weeks after commencing empirical treatment with high-dose oral prednisolone, there was no response; hence, tacrolimus was initiated. Due to concern for maternal and fetal well-being, the decision was made to deliver via Caesarean section at 31 weeks, given worsening proteinuria (23.18 g/24 h). A live male infant was delivered weighing 1625 g. Renal biopsy at 4 weeks post-partum was consistent with primary FSGS. This case highlights the strategies we utilised to manage a gravid patient presenting with nephrotic syndrome at 22 weeks gestation, where diagnosis could only be confirmed on renal biopsy in the postpartum period.
Settler-colonialism in the Late Neocolonial Period
Authors: Ajl Max
Published: November 2024

This essay discusses settler-colonialism in Palestine and the world system during late neocolonialism. It offers a materialist methodology for interpreting settler-colonial social formations, showing the linkage between settler-colonialism, class, imperialism, and world accumulation. It then considers how race continues to structure local reactions and condition local and international attempts at transformation. It concludes with some reflections on contemporary orientations to Palestine in the periphery, especially within racialized social formations.
Controversial Public Issues Discussion: A Vehicle for Disciplinary Literacy in Civics
Authors: Denney Sarah M.
Published: November 2024

This article describes the experience of five high school seniors in a discussion-based, Advanced Placement Government course, in which the teacher of the course frequently implemented controversial public issues (CPI) discussions. By analyzing the ways in which students experienced CPI discussion in their government classroom, the author seeks to better understand the ways in which discussion strategies support the aims of disciplinary literacy in civics. Overall, the discussion-based strategies were successful in supporting the development of disciplinary literacy in civics; however, more intentional connections between CPI discussion and the aims of disciplinary literacy may further enhance the effectiveness of this practice.
Evidence of Strategic Information Literacy Practices in Early Career Teachers' Navigation of TeachersPayTeachers
Authors: Mertens Gillian Emily , Adams Brittany
Published: November 2024

Teachers Pay Teachers (TPT) has emerged as the most popular online educational marketplace of the moment, but exactly how curriculum marketplaces support professional learning and classroom curriculum design is still an emerging area of inquiry in educational research. This paper explores the perspectives of six novice teachers on the supplemental teaching materials available on TPT. Through semi-structured think-aloud interviews, we identified tensions related to teachers’ landscapes of practice, institutional mistrust, perceived authoritativeness of TPT sellers, curriculum marketplaces as altruistic platforms, and the affordances and constraints of TPT for managing finite resources. Findings suggest that professionals who work with preservice and in-service teachers must reframe their discussion of curriculum marketplaces toward developing early-career teachers’ critical curriculum cultivation practices. Such reframing has the potential to influence how educators make use of online curriculum marketplaces, what resources they download, and how those resources are employed.
Retrospective Comparative Study of Lefort I Osteotomies With External or Internal Maxillary Distraction Devices
Authors: Saha Ayush , Law Huay-Zong , Barceló Carlos Raul
Published: November 2024

Introduction:

This investigation aims to evaluate outcomes of LeFort I distraction osteogenesis (DO) using external distraction (ED) versus internal distraction (ID), focusing on acute complication rates and relapse/malocclusion necessitating a secondary LeFort I osteotomy. Factors associated with a higher likelihood of complication and secondary surgery are also described.

Methods:

A retrospective review of 467 electronic medical records was conducted for patients who underwent at least one maxillary or mandibular orthognathic procedure between 2003 and 2023.

Results:

Among these patients, 17% (79/467) underwent LeFort I with maxillary distraction and had at least 30 days of follow-up for acute complications. Eleven percent (50/467) underwent LeFort I with maxillary distraction and had at least 2 years of follow-up for the likelihood of a secondary LeFort I procedure. A statistically significant difference was seen in the number of acute complications for patients who used ED versus ID devices after LeFort I osteotomy with distraction. The need for secondary LeFort I osteotomy was not significantly different between patients using ED and ID devices.

Conclusion:

The complication and reoperation rates reported here may help counsel patients and families about potential outcomes and expectations for LeFort I advancement using ED and ID devices, as well as provide a point of comparison for future investigations.
What We Convey When We Talk About Public Health Crisis: A Case Study of Global Media Coverage of COVID-19 Using Big Data Approach
Authors: Chen Meng , Liu Ke , Zhao Liang , Guo Zhuo
Published: November 2024

This article addresses the urgent need for a comprehensive understanding of the global media coverage of Coronavirus Disease 2019 (COVID-19) by conducting a massive-scale analysis using the Global Database of Events, Language, and Tone. With a dataset encompassing 53,967,878 news items from 4,708 online news sources across 67 countries, the study spans the entire trajectory of the pandemic from the first reported case on December 31, 2019, to September 11, 2020. The analysis aims to surpass the limitations of previous research by offering a worldwide perspective on COVID-19 media coverage over a significant timeframe. Additionally, the paper explores the intricate relationships between media portrayals and the epidemiological situations in primary countries. By examining the media's impact on public perceptions, the study contributes valuable insights to the ongoing discourse on COVID-19, addressing the limitations of prior research and emphasizing the importance of a nuanced and expansive approach to understanding the role of media in the context of global health crises.
Utility of caregiver signaling questions to detect neurocognitive impairment in children with sickle cell disease
Authors: Dandar Christina M. , Kearson Lakia , Longoria Jennifer N. , Potter Brian , King Allison A. , Gossett Jeffrey , Takemoto Clifford M. , Hankins Jane S. , Guolian Kang  , Heitzer Andrew M.
Published: November 2024

The American Society of Hematology cerebrovascular guidelines for sickle cell disease (SCD) recommend surveillance using signaling questions to screen for neurocognitive difficulties, although the clinical utility of these signaling questions has yet to be established. This study aimed to determine the clinical utility of caregiver signaling questions for detecting significant neurocognitive impairment (defined as >1.5 standard deviation [SD] below the normative mean on ≥2 measures) and domain-specific impairment (defined as >1.5 SD below the normative mean) in children and adolescents with SCD. A total of 421 caregivers of children with SCD aged 8 to 17 years (62% hemoglobin SS (HbSS) or hemoglobin S-beta zero (HbSβ0) thalassemia) were asked 7 signaling questions. Children completed performance-based neurocognitive and academic measures. Children who were reported to have repeated a grade, did not obtain primarily A/B grades in school, had a history of learning difficulties, or whose caregiver reported concern for their learning were more likely to have significant neurocognitive impairment and obtained lower scores across all measures (all q < 0.05). History of learning difficulties emerged as the most sensitive and specific signaling question for detecting significant neurocognitive impairment (sensitivity, 0.64; specificity, 0.77) and domain-specific impairment (sensitivity range, 0.56-0.77; specificity range, 0.63-0.72). Cumulative caregiver report improved prediction of neurocognitive impairment beyond demographic/clinical factors alone. Although performance-based screening for all patients with SCD is the most effective means to identify those with neurocognitive or academic impairment, use of caregiver signaling questions represents a brief and low-cost method to improve the detection of patients with SCD in need of support.
Clonal hematopoiesis in patients with autoimmune thrombocytopenia: an international multicenter study
Authors: Fattizzo Bruno , Marchetti Alfredo , Bosi Alessandro , Gurnari Carmelo , Giannotta Juri Alessandro , Pedone Giacinto Luca , Rossi Elena , Carrai Valentina , Guido Andrea , Brioschi Filippo , Carpenedo Monica , Crugnola Monica , Caramazza Domenica , Leuzzi Livia , Marchetti Monia , Merati Gabriele , Malato Simona , Vianello Fabrizio , Patriarca Andrea , Awada Hussein , Bortolotti Marta , Canzi Marta , Bolli Niccolò , Capecchi Marco , Chen Frederick , Artoni Andrea , Maciejewski Jaroslaw P. , Barcellini Wilma
Published: November 2024

Diagnostic boundaries between immune thrombocytopenia (ITP) and other thrombocytopenic states, such as thrombocytopenic myelodysplastic syndromes, may be difficult to establish, and the detection of somatic mutations by next-generation sequencing (NGS) may be of aid. Here, we aimed at characterizing the prevalence and clinical significance of clonal hematopoiesis in ITP. In this multicentric retrospective observational study, we enrolled 167 adult patients with ITP, followed at 13 centers in Italy, United Kingdom, and the United States. Patients underwent NGS evaluation after a median of 3.6 years from ITP onset, and 83% had received at least 1 therapy line, for a median of 2 lines (range, 0-9); 51 of 167 patients (30%) had at least 1 mutation. After exclusion of germ line variants and polymorphisms, 31 of 167 (18.5%) were defined as having clonal hemopoiesis. Most commonly mutated genes were TET2, DNMT3A, SRSF2, and ASXL1 (median variant allele frequency, 29%); 19 of 31 patients (68%) had high-risk variants, and 8 had multiple mutations. Mutated patients were more frequently older males and showed a shorter time from first to second-line therapy, particularly with thrombopoietin receptor agonist (TPO-RA). Additionally, clonal hematopoiesis was associated with increased thrombotic risk (26% vs 8% in NGS-negative cases; P = .01), independently from TPO-RA exposure, though with an age effect. These data demonstrated the prevalence of clonal hematopoiesis in 18% of adult patients with ITP, which is associated with older age, relapsed/refractory disease, and high risk of thrombotic complications.
Lipid metabolism-related gene signature predicts prognosis and unveils novel anti-tumor drugs in specific type of diffuse large B cell lymphoma
Authors: Wang Cancan , Zhang Ran , Zhang Huan , Gao Haixia , Zhu Yubing , Jiao Lichao , Yi Zhiqiang , Zhou Meiyu , Li Xinxia
Published: November 2024

Background

Diffuse large B-cell lymphoma (DLBCL) is the most common type of lymphoma which possess highly aggressive and heterogeneous. Despite advances in understanding heterogeneity and development of novel targeted agents, the prognosis of DLBCL patients remains unsatisfied. Lipids are crucial components of biological membranes and signal transduction while accumulating evidence has supported the vital roles of abnormal lipid metabolism in tumorigenesis. Furthermore, some related pathways could serve as prognostic biomarkers and potential therapeutic targets. However, the clinical significance of abnormal lipid metabolism reprogramming in DLBCL has not been investigated. In the current study, we developed a prognostic risk model for DLBCL based on the abnormal expressed lipid metabolism genes and moreover based on our risk model we classified patients with DLBCL into novel subtypes and identified potential drugs for DLBCL patients with certain lipid metabolism profiles.

Methods

We utilized univariate Cox regression analysis to identify the prognosis-related lipid metabolism genes, and then performed LASSO Cox regression to identify prognostic related lipid metabolism related genes. Multivariate cox regression was used to establish the prognostic model. Patients were divided in to high and low risk groups based on the median risk score. Immune cell infiltration and GSEA were used to identify the pathways between high and low risk groups. Oncopredict algorithm was utilized to identify potential drug for high-risk patients. In vitro cell apoptosis and viability analysis were employed to verify the specific tumor inhibition effects of AZD5153.

Results

Nineteen survival related lipid metabolism genes TMEM176B, LAYN, RAB6B, MMP9, ATAD3B, SLC2A11, CD3E, SLIT2, SLC2A13, SLC43A3, CD6, SIRPG, NEK6, LCP2, CTTN, CXCL2, SNX22, BCL6 and FABP4 were identified and subjected to build the prognostic model which was further verified in four external microarray cohorts and one RNA seq cohorts. Tumor immune microenvironment analysis and GSEA results showed that the activation of MYC targets genes rather than immunosuppression contribute to the poor survival outcome of patients in the high-risk group. AZD5153, a novel bivalent BET bromodomain inhibitor which could inhibit the transcription of MYC and E2F exhibited specific antitumor function for cells with high-risk score.

Conclusions

Our results provide the first lipid metabolism-based gene signature for predicting the survival of patients with DLBCL. Furthermore, by determining novel subtypes with our lipid metabolism prognostic model we illustrated that drugs that compromising MYC target genes rather than immune checkpoint inhibitors may be beneficial to DLBCL patients with certain lipid metabolism profiles.
Novel perspectives on early diagnosis of acute compartment syndrome: the role of admission blood tests
Authors: Wang Tao , Long Yubin , Zhang Qi
Published: November 2024

Purpose

The role of admission blood indicators in patients with acute compartment syndrome (ACS) remains debated. Our primary purpose was to observe variations of admission blood indicators in patients with ACS, while our secondary goal was to explore potential biomarkers related to ACS.

Methods

We collected information on patients with tibial fracture between January 2013 and July 2023, and divided them into ACS and non-ACS groups. Propensity score matching (PSM) analysis was performed to lower the impact of potential confounding variables such as demographics and comorbidities. Admission blood indicators were analyzed using univariate, logistic regression, and receiver operating characteristic (ROC) curve analyses. Then, we established a nomogram prediction model by using R language software.

Results

After propensity PSM analysis, 127 patients were included in each group. Although numerous blood indicators were found to be relevant to ACS on univariate analysis, logistic regression analysis showed that monocytes (MON, p = 0.015), systemic immune-inflammation index (SII, p = 0.011), and creatine kinase myocardial band (CKMB, p < 0.0001) were risk factors for ACS. Furthermore, ROC curve analysis identified 0.79 × 109/L, 1082.55, and 20.99 U/L as the cut-off values to differentiate ACS patients from patients with tibial fracture. We also found that this combination had the highest diagnostic accuracy. Then, we constructed a nomogram prediction model with AUC of 0.869 for the prediction model, with good consistency in the correction curve and good clinical practicality by decision curve analysis.

Conclusions

We found that the levels of MON, SII, and CKMB were related to ACS and may be potential biomarkers. We also identified their cut-off values to separate patients with ACS from those with tibial fracture, helping orthopedists promptly evaluate and take early measures. We established a nomogram prediction model that can efficiently predict ACS in patients with tibial fracture.
Cas9/guide RNA-based gene-drive dynamics following introduction and introgression into diverse anopheline mosquito genetic backgrounds
Authors: Tushar Taylor , Pham Thai Binh , Parker Kiona , Crepeau Marc , Lanzaro Gregory C. , James Anthony A. , Carballar-Lejarazú Rebeca
Published: November 2024

Background

Novel technologies are needed to combat anopheline vectors of malaria parasites as the reductions in worldwide disease incidence has stalled in recent years. Gene drive-based approaches utilizing Cas9/guide RNA (gRNA) systems are being developed to suppress anopheline populations or modify them by increasing their refractoriness to the parasites. These systems rely on the successful cleavage of a chromosomal DNA target site followed by homology-directed repair (HDR) in germline cells to bias inheritance of the drive system. An optimal drive system should be highly efficient for HDR-mediated gene conversion with minimal error rates. A gene-drive system, AgNosCd-1, with these attributes has been developed in the Anopheles gambiae G3 strain and serves as a framework for further development of population modification strains. To validate AgNosCd-1 as a versatile platform, it must perform well in a variety of genetic backgrounds.

Results

We introduced or introgressed AgNosCd-1 into different genetic backgrounds, three in geographically-diverse Anopheles gambiae strains, and one each in an An. coluzzii and An. arabiensis strain. The overall drive inheritance, determined by presence of a dominant marker gene in the F2 hybrids, far exceeded Mendelian inheritance ratios in all genetic backgrounds that produced viable progeny. Haldane’s rule was confirmed for AgNosCd-1 introgression into the An. arabiensis Dongola strain and sterility of the F1 hybrid males prevented production of F2 hybrid offspring. Back-crosses of F1 hybrid females were not performed to keep the experimental design consistent across all the genetic backgrounds and to avoid maternally-generated mutant alleles that might confound the drive dynamics. DNA sequencing of the target site in F1 and F2 mosquitoes with exceptional phenotypes revealed drive system-generated mutations resulting from non-homologous end joining events (NHEJ), which formed at rates similar to AgNosCd-1 in the G3 genetic background and were generated via the same maternal-effect mechanism.

Conclusions

These findings support the conclusion that the AgNosCd-1 drive system is robust and has high drive inheritance and gene conversion efficiency accompanied by low NHEJ mutation rates in diverse An. gambiae s.l. laboratory strains.