bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Materials and Methods and Figures from Histone Acetyltransferase PCAF Is Required for Hedgehog–Gli-Dependent Transcription and Cancer Cell Proliferation
Authors: Malatesta Martina , Steinhauer Cornelia , Mohammad Faizaan , Pandey Deo P. , Squatrito Massimo , Helin Kristian
Published: April 2023

PDF file, 906K, Supplementary Materials and Methods Flow cytometry. Colony formation assay. Supplementary Tables Supplementary Table 1. siRNAs and shRNAs constructs used in this study. Supplementary Table 2. Expression primers and ChIP primers used in this study. Supplementary Table 3. Antibodies used in this study. Supplementary Figures Supplementary Figure S1. Analysis of siRNA screening for acetyltransferases. Supplementary Figure S2. Validation of candidate genes from the siRNA screening. Supplementary Figure S3. Stable depletion of Pcaf does not affect DNA synthesis in NIH3T3 cells. Supplementary Figure S4. Inhibition of PCAF expression affects neurosphere formation and proliferation of GBM543 cells. Supplementary Figure S5. Depletion of PCAF and inhibitors to PCAF induce apoptosis. Supplementary Figure S6. Inhibition of Pcaf expression affects proliferation of tNSCs.
Supplementary Materials and Methods from Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction
Authors: Kudo-Saito Chie , Fuwa Takafumi , Murakami Kouichi , Kawakami Yutaka
Published: April 2023

PDF file, 86K.
Supplementary Figures from Targeting FSTL1 Prevents Tumor Bone Metastasis and Consequent Immune Dysfunction
Authors: Kudo-Saito Chie , Fuwa Takafumi , Murakami Kouichi , Kawakami Yutaka
Published: April 2023

PDF file, 1193K, Figure S1. Snail+ tumor cells frequently metastasize into bone marrow. Figure S2. Differentiation activity of the specific subpopulations isolated from the Snail+ tumor-stimulated BMCs. Figure S3. The Snail+ tumor-induced MSCs promote tumor metastatic seeding into bone. Figure S4. Increase of fstl1 and its receptor dip2a mRNA expressions in Snail+ tumor cells. Figure S5. FSTL1-knockdown suppresses metastatic seeding of human tumor cells into bone. Figure S6. FSTL1-induced cancer bone metastasis mechanism.
Supplementary Figure 7 from Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Authors: Zhang Yaqing , Yan Wei , Collins Meredith A. , Bednar Filip , Rakshit Sabita , Zetter Bruce R. , Stanger Ben Z. , Chung Ivy , Rhim Andrew D. , di Magliano Marina Pasca
Published: April 2023

PDF file - 302K, IL6 deficiency facilitates tissue repair following Kras* inactivation.
Supplementary Table 1 from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling
Authors: Kanda Rina , Kawahara Akihiko , Watari Kosuke , Murakami Yuichi , Sonoda Kahori , Maeda Masashi , Fujita Hideaki , Kage Masayoshi , Uramoto Hidetaka , Costa Carlota , Kuwano Michihiko , Ono Mayumi
Published: April 2023

PDF - 76K, Summary of expression states of integrins and resistance-related molecules in EGFR-TKI sensitive and refractory tumors.
Supplementary Figure 5 from Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Authors: Zhang Yaqing , Yan Wei , Collins Meredith A. , Bednar Filip , Rakshit Sabita , Zetter Bruce R. , Stanger Ben Z. , Chung Ivy , Rhim Andrew D. , di Magliano Marina Pasca
Published: April 2023

PDF file - 227K, IL6 regulates ROS accumulation and survival of PanIN cells.
Supplementary Figure 4 from Interleukin-6 Is Required for Pancreatic Cancer Progression by Promoting MAPK Signaling Activation and Oxidative Stress Resistance
Authors: Zhang Yaqing , Yan Wei , Collins Meredith A. , Bednar Filip , Rakshit Sabita , Zetter Bruce R. , Stanger Ben Z. , Chung Ivy , Rhim Andrew D. , di Magliano Marina Pasca
Published: April 2023

PDF file - 160K, IL6 regulates the fibro-inflammatory environment and survival of pancreatic cancer.
Supplementary Figure 2 from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling
Authors: Kanda Rina , Kawahara Akihiko , Watari Kosuke , Murakami Yuichi , Sonoda Kahori , Maeda Masashi , Fujita Hideaki , Kage Masayoshi , Uramoto Hidetaka , Costa Carlota , Kuwano Michihiko , Ono Mayumi
Published: April 2023

PDF - 163K, A, Establishment of stable integrinβ1-overexpressing cell lines (PC9/ITG2 and PC9/ITG11) or control cDNA transfected cell line (PC9/Mock) from PC9 cells by transfection with integrinβ1 cDNA. B, The effect of integrinβ1 overexpression on erlotinib sensitivity. Transfectants were treated with erlotinib for 3 days, and the IC50 values (μM) for erlotinib were 0.04 (PC9/Mock), 0.09 (PC9/ITG2), and 0.10 (PC9/ITG11). C, Western blots showing the expression and phosphorylation of EGFR, integrinβ1, Akt, and Erk1/2 following exposure to erlotinib for 5 hr.
Supplementary Figure 1 from Erlotinib Resistance in Lung Cancer Cells Mediated by Integrin β1/Src/Akt-Driven Bypass Signaling
Authors: Kanda Rina , Kawahara Akihiko , Watari Kosuke , Murakami Yuichi , Sonoda Kahori , Maeda Masashi , Fujita Hideaki , Kage Masayoshi , Uramoto Hidetaka , Costa Carlota , Kuwano Michihiko , Ono Mayumi
Published: April 2023

PDF- 199K, A, Heterodimerization of integrinα2 or α5 with integrinβ1. B, Effects of integrinβ1, α2, or α5 siRNA, with or without erlotinib treatment, on downstream signaling molecules in PC9/ER2-2 cells.
Supplementary Figures 1-6 from Antitumor Immunotherapeutic and Toxic Properties of an HDL-Conjugated Chimeric IL-15 Fusion Protein
Authors: Ochoa Maria C. , Fioravanti Jessica , Rodriguez Inmaculada , Hervas-Stubbs Sandra , Azpilikueta Arantza , Mazzolini Guillermo , Gúrpide Alfonso , Prieto Jesus , Pardo Julian , Berraondo Pedro , Melero Ignacio
Published: April 2023

PDF file - 214K, Fig S1: Inhibition of several cytokines does not modify pneumonitis lethality in mice treated with pSushi-IL15-Apo. Fig S2: Pharmacokinetics, bioactivity and incorporation into HDL of Sushi-IL15. Fig. S3: Time course follow-up of lymphocyte numbers in lung liver and spleen after pSushi-IL15-Apo liver gene transfer. Fig. S4: Liver gene transfer of pSushi-IL15-Apo results in intense proliferation of NK and CD8 T lymphocytes. Fig. S5: In vivo bioactivity of rSushi-IL15-Apo. Fig. S6: Repeated hydrodynamic injections achieve similar effects
Supplementary Figures 1 - 11 from Lenalidomide Inhibits Lymphangiogenesis in Preclinical Models of Mantle Cell Lymphoma
Authors: Song Kai , Herzog Brett H. , Sheng Minjia , Fu Jianxin , McDaniel J. Michael , Ruan Jia , Xia Lijun
Published: April 2023

PDF file - 4999K, Supplementary Figure S1. Characterization of lymphatic vessels in non-reactive lymph nodes and mantle cell lymphoma xenografts. Supplementary Figure S2. LEN treatment decreases MCL dissemination. Supplementary Figure S3. LEN treatment does not affect the function of pre-existing host collecting lymphatic vessels. Supplementary Figure S4. Disseminated MCL tumor cells are within the lymphatic vessels in the distant axillary lymph nodes. Supplementary Figure S5. LEN treatment does not affect the proliferation, survival, or migration of lymphatic endothelial cells in vitro. Supplementary Figure S6. Gene expression profiles of lymphatic endothelial cells, macrophages and MCL xenografts after LEN treatment. Supplementary Figure S7. LEN treatment decreases macrophages in tumor peripheral regions. Supplementary Figure S8. LEN treatment does not affect the proliferation, survival, migration or VEGF-C expression of macrophages in vitro. Supplementary Figure S9. Clodrolip treatment results in significant macrophage depletion at tumor peripheral regions. Supplementary Figure S10. Tumor lymphangiogenesis is affected at early stage after LEN treatment. Supplementary Figure S11. LEN treatment inhibits functional angiogenesis.
Supplementary Figure Legends from Indirubin Derivative 6BIO Suppresses Metastasis
Authors: Braig Simone , Kressirer Christine A. , Liebl Johanna , Bischoff Fabian , Zahler Stefan , Meijer Laurent , Vollmar Angelika M.
Published: April 2023

PDF file, 77K.
Supplementary Materials and Methods from Vaccine-Instructed Intratumoral IFN-γ Enables Regression of Autochthonous Mouse Prostate Cancer in Allogeneic T-Cell Transplantation
Authors: Hess Michelini Rodrigo , Manzo Teresa , Sturmheit Tabea , Basso Veronica , Rocchi Martina , Freschi Massimo , Listopad Joanna , Blankenstein Thomas , Bellone Matteo , Mondino Anna
Published: April 2023

PDF - 79K, Immunofluorescence analysis.
Supplementary Figure Legends from SOX2 Expression Associates with Stem Cell State in Human Ovarian Carcinoma
Authors: Bareiss Petra M. , Paczulla Anna , Wang Hui , Schairer Rebekka , Wiehr Stefan , Kohlhofer Ursula , Rothfuss Oliver C. , Fischer Anna , Perner Sven , Staebler Annette , Wallwiener Diethelm , Fend Falko , Fehm Tanja , Pichler Bernd , Kanz Lothar , Quintanilla-Martinez Leticia , Schulze-Osthoff Klaus , Essmann Frank , Lengerke Claudia
Published: April 2023

PDF file, 72K.
Supplementary Methods from Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis
Authors: O'Hare Thomas , Eide Christopher A. , Agarwal Anupriya , Adrian Lauren T. , Zabriskie Matthew S. , MacKenzie Ryan J. , LaTocha Dorian H. , Johnson Kara J. , You Huihong , Luo Jenny , Riddle Steven M. , Marks Bryan D. , Vogel Kurt W. , Koop Dennis R. , Apgar John , Tyner Jeffrey W. , Deininger Michael W. , Druker Brian J.
Published: April 2023

PDF file - 47K, Includes cellular proliferation assays, immunoblot analysis, continuous drug exposure assay, and detection of inhibitors/inhibitor dissociation studies.
Supplementary Figures from Antitumor Efficacy of a Monoclonal Antibody That Inhibits the Activity of Cancer-Associated Carbonic Anhydrase XII
Authors: Gondi Gabor , Mysliwietz Josef , Hulikova Alzbeta , Jen Jian Ping , Swietach Pawel , Kremmer Elisabeth , Zeidler Reinhard
Published: April 2023

PDF file, 299K, Figure S1 shows the homogenous GFP expression of the A549 single cell clone used for the in vivo experiments. Figure S2 illustrates the distribution of the labeled 6A10 antibody and compares it to the localization of the xenografts. Figure S3 shows the tumor burden of xenograft-carrying mice at day 81 post inoculation. Figure S4 show hematoxylin/eosin stains of xenografts with adjacent normal tissues.
Supplementary Figure S2 from Peroxiredoxin-2 Represses Melanoma Metastasis by Increasing E-Cadherin/β-Catenin Complexes in Adherens Junctions
Authors: Lee Doo Jae , Kang Dong Hoon , Choi Mina , Choi Yang Ji , Lee Joo Young , Park Joo Hyun , Park Yoon Jung , Lee Kyung Wha , Kang Sang Won
Published: April 2023

Supplementary Figure S2�- PDF file 425K, Peroxidase activity of Prx2 is essential for regulating melanoma cell function
Supplementary Materials and Methods from Histone Demethylase RBP2 Promotes Lung Tumorigenesis and Cancer Metastasis
Authors: Teng Yu-Ching , Lee Cheng-Feng , Li Ying-Shiuan , Chen Yi-Ren , Hsiao Pei-Wen , Chan Meng-Yu , Lin Feng-Mao , Huang Hsien-Da , Chen Yen-Ting , Jeng Yung-Ming , Hsu Chih-Hung , Yan Qin , Tsai Ming-Daw , Juan Li-Jung
Published: April 2023

Supplementary Materials and Methods - PDF file 152K, Additional data including Western Blot, Plasmids, RT-qPCR, ChIP and DNA primers
Supplementary Figure Legend from Preventing Postoperative Metastatic Disease by Inhibiting Surgery-Induced Dysfunction in Natural Killer Cells
Authors: Tai Lee-Hwa , de Souza Christiano Tanese , Bélanger Simon , Ly Lundi , Alkayyal Almohanad A. , Zhang Jiqing , Rintoul Julia L. , Ananth Abhirami A. , Lam Tiffany , Breitbach Caroline J. , Falls Theresa J. , Kirn David H. , Bell John C. , Makrigiannis Andrew P. , Auer Rebecca A.
Published: April 2023

PDF file - 65K
Figure S1 from Hbo1 Is a Cyclin E/CDK2 Substrate That Enriches Breast Cancer Stem-like Cells
Authors: Duong MyLinh T. , Akli Said , Macalou Sira , Biernacka Anna , Debeb Bisrat G. , Yi Min , Hunt Kelly K. , Keyomarsi Khandan
Published: April 2023

Figure S1: LMW-E-expressing tumor cells exhibit enhanced cell migration properties.
Supplementary Methods from Epimorphin Is a Novel Regulator of the Progesterone Receptor Isoform-A
Authors: Bascom Jamie L. , Radisky Derek C. , Koh Eileen , Fata Jimmie E. , Lo Alvin , Mori Hidetoshi , Roosta Neda , Hirai Yohei , Bissell Mina J.
Published: April 2023

PDF file, 81K.
Supplementary Table 1 from Superior Penetration and Retention Behavior of 50 nm Gold Nanoparticles in Tumors
Authors: Huo Shuaidong , Ma Huili , Huang Keyang , Liu Juan , Wei Tuo , Jin Shubin , Zhang Jinchao , He Shengtai , Liang Xing-Jie
Published: April 2023

PDF file - 36K, Average Au concentration in different organs (mug Au/g tissue) after 24 h administration of 50 nm and 100 nm Au@tiopronin nanoparticles
Supplementary Figures 1 - 7 from Gut Microbiota Protects against Gastrointestinal Tumorigenesis Caused by Epithelial Injury
Authors: Zhan Yu , Chen Po-Ju , Sadler William D. , Wang Fuyuan , Poe Sara , Núñez Gabriel , Eaton Kathryn A. , Chen Grace Y.
Published: April 2023

PDF file - 615K, Increased mortality of GF mice with high concentrations of DSS (S1); Tumors in GF mice have similar nuclear beta-catenin localization as tumors in SPF mice (S2); Percent weight change from baseline (start of DSS) for GF and SPF mice with AOM and 1.5% DSS (S3); Increased inflammatory cell recruitment in SPF mice early after DSS-induced intestinal injury (S4); Tumors in GF mice have similar proliferative activity as tumors in SPF mice (S5); Recolonization of GF mice with the gut microbiota reduces mortality to DSS (S6); Recolonization of GF mice with the gut microbiota restores ability of GF mice to induce reparative inflammation (S7).
Supplementary Figure 4 from Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Authors: Markant Shirley L. , Esparza Lourdes Adriana , Sun Jesse , Barton Kelly L. , McCoig Lisa M. , Grant Gerald A. , Crawford John R. , Levy Michael L. , Northcott Paul A. , Shih David , Remke Marc , Taylor Michael D. , Wechsler-Reya Robert J.
Published: April 2023

PDF file - 1514K, Supplemental Figure 4: Plk and Aurk inhibitors enhance sensitivity to radiation.
Supplementary Figure 1 from Targeting Sonic Hedgehog-Associated Medulloblastoma through Inhibition of Aurora and Polo-like Kinases
Authors: Markant Shirley L. , Esparza Lourdes Adriana , Sun Jesse , Barton Kelly L. , McCoig Lisa M. , Grant Gerald A. , Crawford John R. , Levy Michael L. , Northcott Paul A. , Shih David , Remke Marc , Taylor Michael D. , Wechsler-Reya Robert J.
Published: April 2023

PDF file - 3091K, Supplemental Figure 1: Cell cycle progression occurs more rapidly in CD15+ cells than in CD15- cells.
Supplementary Figure S5 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: April 2023

PDF file - 208K, Micronuclei in pancreatic cancer cells
Supplementary Figure S4 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: April 2023

PDF file - 382K, HPDE-KrasG12D produces exDNA that affect cell migration and invasion
Supplementary Figure S3 from Extracellular DNA in Pancreatic Cancer Promotes Cell Invasion and Metastasis
Authors: Wen Fushi , Shen Alex , Choi Andrew , Gerner Eugene W. , Shi Jiaqi
Published: April 2023

PDF file - 1673K, DNase I does not degrade integrin beta 1
Supplementary Figure Legend from Dysregulated Expression of FOXM1 Isoforms Drives Progression of Pancreatic Cancer
Authors: Kong Xiangyu , Li Lei , Li Zhaoshen , Le Xiangdong , Huang Chen , Jia Zhiliang , Cui Jiujie , Huang Suyun , Wang Liwei , Xie Keping
Published: April 2023

PDF file - 103K
Supplementary Figure 3 from Obesity Promotes Breast Cancer by CCL2-Mediated Macrophage Recruitment and Angiogenesis
Authors: Arendt Lisa M. , McCready Jessica , Keller Patricia J. , Baker Dana D. , Naber Stephen P. , Seewaldt Victoria , Kuperwasser Charlotte
Published: April 2023

PDF file, 390K, Macrophage-derived CXCL12 increases angiogenesis.
Supplementary Figure 4 from An Antibody That Locks HER3 in the Inactive Conformation Inhibits Tumor Growth Driven by HER2 or Neuregulin
Authors: Garner Andrew P. , Bialucha Carl U. , Sprague Elizabeth R. , Garrett Joan T. , Sheng Qing , Li Sharon , Sineshchekova Olga , Saxena Parmita , Sutton Cammie R. , Chen Dongshu , Chen Yan , Wang Huiqin , Liang Jinsheng , Das Rita , Mosher Rebecca , Gu Jian , Huang Alan , Haubst Nicole , Zehetmeier Carolin , Haberl Manuela , Elis Winfried , Kunz Christian , Heidt Analeah B. , Herlihy Kara , Murtie Joshua , Schuller Alwin , Arteaga Carlos L. , Sellers William R. , Ettenberg Seth A.
Published: April 2023

PDF file - 272K, Figure S4. The NRG1/ HER3 binding affinity is unaffected by LJM716.
Supplementary Table 3 from Characterization of Rearrangements Involving the ALK Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma
Authors: Cazes Alex , Louis-Brennetot Caroline , Mazot Pierre , Dingli Florent , Lombard Bérangère , Boeva Valentina , Daveau Romain , Cappo Julie , Combaret Valérie , Schleiermacher Gudrun , Jouannet Stéphanie , Ferrand Sandrine , Pierron Gaëlle , Barillot Emmanuel , Loew Damarys , Vigny Marc , Delattre Olivier , Janoueix-Lerosey Isabelle
Published: April 2023

PDF file - 207K, Primers used to prepare 5-kb PCR probes and BAC used for FISH analysis
Supplementary Materials and Methods from Pharmacological Inhibition of the Wnt Acyltransferase PORCN Prevents Growth of WNT-Driven Mammary Cancer
Authors: Proffitt Kyle David , Madan Babita , Ke Zhiyuan , Pendharkar Vishal , Ding Lijun , Lee May Ann , Hannoush Rami N. , Virshup David M.
Published: April 2023

PDF file - 156KB
Supplementary Table 1 from Characterization of Rearrangements Involving the ALK Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma
Authors: Cazes Alex , Louis-Brennetot Caroline , Mazot Pierre , Dingli Florent , Lombard Bérangère , Boeva Valentina , Daveau Romain , Cappo Julie , Combaret Valérie , Schleiermacher Gudrun , Jouannet Stéphanie , Ferrand Sandrine , Pierron Gaëlle , Barillot Emmanuel , Loew Damarys , Vigny Marc , Delattre Olivier , Janoueix-Lerosey Isabelle
Published: April 2023

PDF file - 151K, Regions targeted for the capture/paired-end sequencing approach
Supplementary Methods from Characterization of Rearrangements Involving the ALK Gene Reveals a Novel Truncated Form Associated with Tumor Aggressiveness in Neuroblastoma
Authors: Cazes Alex , Louis-Brennetot Caroline , Mazot Pierre , Dingli Florent , Lombard Bérangère , Boeva Valentina , Daveau Romain , Cappo Julie , Combaret Valérie , Schleiermacher Gudrun , Jouannet Stéphanie , Ferrand Sandrine , Pierron Gaëlle , Barillot Emmanuel , Loew Damarys , Vigny Marc , Delattre Olivier , Janoueix-Lerosey Isabelle
Published: April 2023

PDF file - 138K, Supplementary Methods for SNP 6.0 arrays, NimbleGen arrays, analysis of reads obtained using capture and paired-end sequencing, mass spectrometry analysis and inverse PCR
Supplementary Figures 1 - 8 from A Novel Model of Dormancy for Bone Metastatic Breast Cancer Cells
Authors: Marlow Rebecca , Honeth Gabriella , Lombardi Sara , Cariati Massimiliano , Hessey Sonya , Pipili Aikaterini , Mariotti Veronica , Buchupalli Bharath , Foster Katie , Bonnet Dominique , Grigoriadis Agamemnon , Rameshwar Pranela , Purushotham Anand , Tutt Andrew , Dontu Gabriela
Published: April 2023

PDF file - 1575K, Supplementary Figure 1. Set-up of the two bone marrow metastatic niche models - Inhibitory Niche (Bone Marrow Cell lines, BMCL) and Supportive Niche (Human Bone Marrow Stromal Cells, BMSC). Supplementary Figure 2. Set-up of bone marrow metastatic niche models, including coculture with mouse BMSC and the cell lines 293t, fetal kidney, U2OS and MG63, osteosarcoma and organ-specific metastatic sub-lines of MDA-MB-231, 1833 BoM and 4175 LM2. Supplementary Figure 3. Control experiments for set-up of bone marrow metastatic niche models. Supplementary Figure 4 Breast cancer cells in IN co-culture did not undergo apoptosis were viable and capable to proliferate. Supplementary Figure 5. Conditioned medium from IN culture induced cell cycle arrest in breast cancer cells. Supplementary Figure 6. Effects of small molecule inhibitors SB431542 (Alk5), SB203580 (p38) and S1042 (RTK) in 3D co-cultures of breast cancer cell lines. Supplementary Figure 7. Treatment with small molecule inhibitors induced growth of BCC in the subcutaneous implantation model. Supplementary Figure 8 Breast cancer cell lines proliferation in orthotopic and metastasis mouse models (intratibial and intracardiac injection).
Supplementary Figure 2 from Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
Authors: Velpula Kiran Kumar , Bhasin Arnima , Asuthkar Swapna , Tsung Andrew J.
Published: April 2023

PDF file - 165K, Supplementary Figure 2. Immunohistochemical staining demonstrates PDK1-pEGFR-COX2 co-localization in hGBM specimens. Double-label immuno-fluorescence staining for PDK1-pEGFR-COX2 on normoxic and induced hypoxic (CoCl2) treated U251 and 5310 cells.
Supplementary Figure 1 from Combined Targeting of PDK1 and EGFR Triggers Regression of Glioblastoma by Reversing the Warburg Effect
Authors: Velpula Kiran Kumar , Bhasin Arnima , Asuthkar Swapna , Tsung Andrew J.
Published: April 2023

PDF file - 300K, Supplementary Figure 1. Confocal images of hGBM patient specimens expressing pEGFR and PDK1.
Supplementary Table 7 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 12967K, RNA-seq of MCF7 overexpressed with miR-515-5p.
Supplementary Figure Legends from FGFR1 Is Essential for Prostate Cancer Progression and Metastasis
Authors: Yang Feng , Zhang Yongyou , Ressler Steven J. , Ittmann Michael M. , Ayala Gustavo E. , Dang Truong D. , Wang Fen , Rowley David R.
Published: April 2023

PDF File - 79K, Legends for Supplementary Figures S1-S4.
Supplementary Figure 4 from FGFR1 Is Essential for Prostate Cancer Progression and Metastasis
Authors: Yang Feng , Zhang Yongyou , Ressler Steven J. , Ittmann Michael M. , Ayala Gustavo E. , Dang Truong D. , Wang Fen , Rowley David R.
Published: April 2023

PDF File - 101K, TUNEL staining.
Supplementary Figure Legends from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 78K.
Supplementary Figure 3 from FGFR1 Is Essential for Prostate Cancer Progression and Metastasis
Authors: Yang Feng , Zhang Yongyou , Ressler Steven J. , Ittmann Michael M. , Ayala Gustavo E. , Dang Truong D. , Wang Fen , Rowley David R.
Published: April 2023

PDF File - 102K, Controls for in situ hybridization.
Supplementary Figure 2 from FGFR1 Is Essential for Prostate Cancer Progression and Metastasis
Authors: Yang Feng , Zhang Yongyou , Ressler Steven J. , Ittmann Michael M. , Ayala Gustavo E. , Dang Truong D. , Wang Fen , Rowley David R.
Published: April 2023

PDF File - 63KGeneration of TRAMP mice with conditional knockout of fgfr1 in prostate epithelium.
Supplementary Figure 4 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 11170K, Figure S4. AUBPs (HuR and AUF1) mRNA expression is not altered upon estrogen treatment. GEO2R analysis of HuR mRNA levels (ELAVL1 gene) AUF1 mRNA levels (HNRNPD gene) using 8 published expression profiling datasets.
Supplementary Figure 1 from FGFR1 Is Essential for Prostate Cancer Progression and Metastasis
Authors: Yang Feng , Zhang Yongyou , Ressler Steven J. , Ittmann Michael M. , Ayala Gustavo E. , Dang Truong D. , Wang Fen , Rowley David R.
Published: April 2023

PDF File - 448K, Ablation of fgfr1 from embryonic prostate epithelium does not affect prostate gland development or androgen action.
Supplementary Figure 1 from Downregulation of microRNA-515-5p by the Estrogen Receptor Modulates Sphingosine Kinase 1 and Breast Cancer Cell Proliferation
Authors: Pinho Filipa G. , Frampton Adam E. , Nunes Joao , Krell Jonathan , Alshaker Heba , Jacob Jimmy , Pellegrino Loredana , Roca-Alonso Laura , de Giorgio Alexander , Harding Victoria , Waxman Jonathan , Stebbing Justin , Pchejetski Dmitry , Castellano Leandro
Published: April 2023

PDF file, 10214K, Figure S1. (A) miRNAs predicted to target SK1 3'UTR using TargetScan. miRNAs targeting SK1 3'UTR were predicted using the web-based software, TargetScan. The miRNAs highlighted were selected for further analysis and experiments. (B) The effect of miR-206 and miR-515-5p overexpression on SK1 mRNA levels and (C) phospho-ERK 1/2 expression. MCF7 cells were transfected with 50nM of precursor miRNAs. After 48 hours, SK1 mRNA levels were measured by RT-qPCR and phospho-ERK 1/2 protein levels were analyzed by Immuno-blotting. Data presented are the mean plus-minus SEM (***P<0.001). (D) miRNA-515-5p directly interact with SK1 3'UTR. Cells were co-transfected with 50nM of pre-miRs, 100ng of pMIR-SK1 3'UTR or pMIR-SK1 3'UTRMUT and 50ng of pRLTK (Renilla luciferase vector). After 24 hours, both Firefly and Renilla luciferase activities were measured. Data were normalized to the negative control result (miR NC) and presented as the mean of three independent experiments plus-minus SEM. P values were calculated by t-test comparing individual miR values with miR NC values. (*P<0.05; **P<0.01; ***P<0.001).
Supplementary Figures 1-4, Tables 1-2 from MYC Acts via the PTEN Tumor Suppressor to Elicit Autoregulation and Genome-Wide Gene Repression by Activation of the Ezh2 Methyltransferase
Authors: Kaur Mandeep , Cole Michael D.
Published: April 2023

PDF file - 496K, Fig. S1-Immunoblot of Myc levels. Fig. S2-RT-PCR and Western blots of Ezh2 RNA and protein levels. Fig. S3-ChIP for Ring1b, H3K27 and Myc in different cell lines. Fig. S4-RT-PCR of select genes with siRNAs against Ezh2, PTEN or Miz1. Table S1-Myc activated genes that are unaltered by enhanced Ezh2 activity. Table S2-siRNA sequences used in experiments
Supplementary Table S2 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Table S2 - PDF file 1431K, Germline immunoglobulin gene usages of the predicted amino-acid sequence of the anti-B7-H4 scFvs
Supplementary Table S1 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Table S1 - PDF file 1334K, B7-H4 expression on tumor cells derived from human ovarian cancer ascites and solid tumors
Supplementary Figure and Table Legends from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Figure and Table Legends - PDF file100K, Legend for Supplementary Figures S1-S5 and Supplementary Tables S1-S2
Supplementary Figure S5 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Figure S5 - PDF file 2023K, In vitro tumor-polarized TAMs downregulate antigen-specific T cells proliferation and co-stimulation
Supplementary Figure S4 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Figure S4 - PDF file 1076K, ELISA validation of isolated anti-B7-H4 scFvs
Supplementary Methods from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 150K, Additional experimental procedures and list of Primers.
Supplementary Figure Legend from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 95K
Supplementary Figure S2 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Figure S2 - PDF file 1219K, Analysis of B7-H4 expression in human ovarian cancer cells
Supplementary Figure S1 from Novel Recombinant Human B7-H4 Antibodies Overcome Tumoral Immune Escape to Potentiate T-Cell Antitumor Responses
Authors: Dangaj Denarda , Lanitis Evripidis , Zhao Aizhi , Joshi Shree , Cheng Yi , Sandaltzopoulos Raphael , Ra Hyun-Jeong , Danet-Desnoyers Gwenn , Powell Daniel J. , Scholler Nathalie
Published: April 2023

Supplementary Figure S1 - PDF file 1189K, Cloning, expression and purification of recombinant B7-H4
Supplementary Figure 5 from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 115K, ErbB2KI/shCtnnb1-derived mammary tumors show impaired β-catenin signalling.
Supplementary Methods from Supramolecular Nanoparticles That Target Phosphoinositide-3-Kinase Overcome Insulin Resistance and Exert Pronounced Antitumor Efficacy
Authors: Kulkarni Ashish A. , Roy Bhaskar , Rao Poornima S. , Wyant Gregory A. , Mahmoud Ayaat , Ramachandran Madhumitha , Sengupta Poulomi , Goldman Aaron , Kotamraju Venkata Ramana , Basu Sudipta , Mashelkar Raghunath A. , Ruoslahti Erkki , Dinulescu Daniela M. , Sengupta Shiladitya
Published: April 2023

PDF file - 74K
Supplementary Figure 3 from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 104K, Comparison of ErbB2KI, MMTV/NIC, and other transgenic mouse models of breast cancer.
Supplementary Figure 1 from β-Catenin Signaling Is a Critical Event in ErbB2-Mediated Mammary Tumor Progression
Authors: Schade Babette , Lesurf Robert , Sanguin-Gendreau Virginie , Bui Tung , Deblois Geneviève , O'Toole Sandra A. , Millar Ewan K.A. , Zardawi Sara J. , Lopez-Knowles Elena , Sutherland Robert L. , Giguère Vincent , Kahn Michael , Hallett Michael , Muller William J.
Published: April 2023

PDF file - 139K, ErbB2KI mammary tumors express basal/myoepithelial markers and contain cells co-expressing Krt8 and Krt14.
Supplementary Figure 1 from Inhibition of AMPK and Krebs Cycle Gene Expression Drives Metabolic Remodeling of Pten-Deficient Preneoplastic Thyroid Cells
Authors: Antico Arciuch Valeria G. , Russo Marika A. , Kang Kristy S. , Di Cristofano Antonio
Published: April 2023

PDF file - 7221K, PI3K-mediated TCA cycle repression in human tumors.
Supplementary Table 2 from Mathematical Modeling of Tumor Cell Proliferation Kinetics and Label Retention in a Mouse Model of Lung Cancer
Authors: Zheng Yanyan , Moore Helen , Piryatinska Alexandra , Solis Trinidad , Sweet-Cordero E. Alejandro
Published: April 2023

PDF File - 65K, Quantification of percentage of cell death in KrasG12D tumors.
Supplementary Table 1 from Mathematical Modeling of Tumor Cell Proliferation Kinetics and Label Retention in a Mouse Model of Lung Cancer
Authors: Zheng Yanyan , Moore Helen , Piryatinska Alexandra , Solis Trinidad , Sweet-Cordero E. Alejandro
Published: April 2023

PDF File - 63K, Quantification of median tumor cell cross-sectional area.
Supplementary Table 1 from Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network
Authors: Vera Julio , Schmitz Ulf , Lai Xin , Engelmann David , Khan Faiz M. , Wolkenhauer Olaf , Pützer Brigitte M.
Published: April 2023

PDF file - 48K, Topological properties of the E2F1-p73/DNp73-miR-205 network
Supplementary Figure 1 from Mathematical Modeling of Tumor Cell Proliferation Kinetics and Label Retention in a Mouse Model of Lung Cancer
Authors: Zheng Yanyan , Moore Helen , Piryatinska Alexandra , Solis Trinidad , Sweet-Cordero E. Alejandro
Published: April 2023

PDF File - 490K, Representative CC3 staining for a KrasG12D tumor.
Supplementary Figure 3 from Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network
Authors: Vera Julio , Schmitz Ulf , Lai Xin , Engelmann David , Khan Faiz M. , Wolkenhauer Olaf , Pützer Brigitte M.
Published: April 2023

PDF file - 33K, Fitting of the model to the experimental data
Supplementary Table S2 from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

Supplementary Table S2 - PDF file 19K, Pharmacokinetic parameters of G007-LK and G244-LM
Supplementary Figure 2 from Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network
Authors: Vera Julio , Schmitz Ulf , Lai Xin , Engelmann David , Khan Faiz M. , Wolkenhauer Olaf , Pützer Brigitte M.
Published: April 2023

PDF file - 199K, Feedforward loops detected in the E2F1‐p73/DNp73‐miR‐205 regulatory map
Supplementary Figure 1 from Kinetic Modeling–Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network
Authors: Vera Julio , Schmitz Ulf , Lai Xin , Engelmann David , Khan Faiz M. , Wolkenhauer Olaf , Pützer Brigitte M.
Published: April 2023

PDF file - 407K, E2F1-p73/DNp73-miR-205 regulatory map
Supplementary Table 3 from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

PDF file - 58K, G007-LK effects on tumor growth and mouse body weight in xenograft efficacy studies
Supplementary Video 6 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

AVI file - 650KB, Time-lapse live imaging of H2B-EGFP-expressing, Aurora-A deficient MEFs undergoing abnormal cell cycle.
Supplementary Figure S3 from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

Supplementary Fig. S3 - PDF file 1785K,Pharmacokinetic and anti-tumor efficacy properties of tankyrase inhibitors. (A) Pharmacokinetic parameters for G007-LK and G244-LM determined from the mouse studies described in Fig. 4A. (B) G007-LK exposure in plasma and HCT-15 xenograft tumors at 8, 16, and 24 h after a single G007-LK IP dose for the tumor study shown in Fig. 4B and 4C. (C) Tabulated summary of the percent tumor growth inhibition (%TGI) for the indicated doses of G007-LK in the COLO-320DM tumor efficacy study of Fig. 4D and SW403 tumor study of Fig. 5A (right table). The area under the curve (AUC) was calculated from the LME-fitted values and used to calculate %TGI. The tables also list the upper and lower 95th percentile confidence intervals (CI) for the calculated %TGI of each treatment group, as well as the percent body weight change (%BW) based upon the LME-fitted curves at the end of the study and at the time of maximal loss. (D) G007-LK exposure levels in mouse sera (upper graphs) and tumors (lower graphs) collected 16 h after the last dose from tumor efficacy studies of COLO-320DM (Fig. 4D), SW403 (Fig. 5A), HCT-15 (Fig. 5D), and DLD-1 (Fig. 5D) xenografts. (E) Adenoma image quantification for groups of five ApcCKO/CKO Lgr5-CreERT2+ mice treated with 50 mg/kg G007-LK PO QD or control vehicle for 19 days. Neoplastic tumor lesions were identified in sections of the ileum based on high levels of �-catenin immunohisotochemical staining using Ellipse software analysis. Graphs show the total tumor area (left) and number of tumor lesions (right) in each ileum, with black mean bars and blue SEM error bars marked. The distributions in the groups differed significantly for tumor area (P<0.01 by the Mann-Whitney rank-sum test for the non-normal distributions) and for lesion number (P<0.05 by the Student's t-test). (F) Representative microscopy images of ileum sections used for the quantification in (E), stained with anti-�-catenin antibody and H&E. Left panels show control vehicle-treated intestines, with epithelial lesions marked with arrowheads, and right panels display intestines from G007-LK-treated mice. Scale bars in each image represent 0.1 mm
Supplementary Video 5 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

AVI file - 439KB, Time-lapse live imaging of H2B-EGFP-expressing, Aurora-A deficient MEFs undergoing abnormal cell cycle.
Supplementary Figure S2 from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

Supplementary Fig. S2 - PDF file 365K, Tankyrase and receptor tyrosine kinase pathway inhibitor effects on CRC cell line and intestinal organoid growth.(A) Percentage of cells for the indicated three cell lines showing phospho-histone H3 staining as a marker for mitosis (left graph) or EdU staining as a marker for S-phase of the cell cycle (right graph) after treatment with G007-LK or G244-LM for 24 h. (B) Dose-response curves for cell proliferation of CRC cell lines treated four days with the indicated MEK1/2 inhibitor (GDC-0973), TNKS1/2 inhibitor (G007-LK and G244-LM), or combination treatment, normalized to control DMSO treatments for the same cell line. The upper two graphs show results for MEK and two TNKS inhibitors on four APC-mutant cell lines, as indicated, and the lower graph shows combination MEK inhibitor treatments with 0.5 �mol/L G007-LK or G244-LM in DLD-1 cells. (C) Colony formation (upper graph) for COLO-320DM cells treated with tankyrase inhibitor (0.2 �mol/L G244-LM or G007-LK) and MEK inhibitor (GDC-0973 at the indicated �mol/L concentrations in parentheses) individually or in combination for 13 day. BIM1 (middle graph) and AXIN2 (lower graph) RNA expression is shown for similar HCT-15 cell treatments for 4 days. (D) Dose-response curves for normal mouse small intestine organoid growth after treating in culture for 4 days with tankyrase (G007-LK or G244-LM) or EGFR (erlotinib) inhibitor. Control 0.2% DMSO wells contained 32.0 � 7.6 organoids
Supplementary Video 4 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

AVI file - 422KB, Time-lapse live imaging of H2B-EGFP-expressing, Aurora-A deficient MEFs undergoing abnormal cell cycle.
Supplementary Figure S1 from A Novel Tankyrase Small-Molecule Inhibitor Suppresses APC Mutation–Driven Colorectal Tumor Growth
Authors: Lau Ted , Chan Emily , Callow Marinella , Waaler Jo , Boggs Jason , Blake Robert A. , Magnuson Steven , Sambrone Amy , Schutten Melissa , Firestein Ron , Machon Ondrej , Korinek Vladimir , Choo Edna , Diaz Dolores , Merchant Mark , Polakis Paul , Holsworth Daniel D. , Krauss Stefan , Costa Mike
Published: April 2023

Supplementary Fig. S1 - PDF file 341K, Tankyrase inhibitor effects on APC-wildtype and -mutant cell lines. (A) Dose-response curves of three tankyrase inhibitors for TOPbrite Wnt/�-catenin luciferase reporter activity and cell viability (upper graph), and for Wnt target gene expression (Axin2 and Lgr5; lower two graphs), in APC-wildtype mouse 10T1/2 cells. (B) Western immunoblot (upper panel) of cytosolic proteins from hypotonic lysis of the APC-mutant cell lines indicated after treatment with 0.5 �mol/L G007-LK or control DMSO for 16 h. Cell lines sensitive (S, green) or resistant (R, red) to Wnt/�-catenin signaling inhibition by tankyrase inhibitors are marked as in Fig. 2B. Lower two graphs show quantification of the relative band intensities normalized to GAPDH in the same lane of the immunoblot
Supplementary Table 3 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 74K, Age, anthropometric characteristics of control and cases series and clinical characteristics of breast cancer patients.
Supplementary Figure 6 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 239KB, Abnormal differentiation in Aurora-A null cancer cells.
Supplementary Figure 4 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 198K, Expression of Wnt3a in a panel of breast cancer cell lines.
Supplementary Figure 4 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 430KB, Proliferation markers are reduced in low proliferative tissues of Aurora-A deficient mice.
Supplementary Figure 3 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 153K, Cocultivated human mammary adipocytes overexpress FSP-1, but not alphaSMA, and exhibit an activated phenotype.
Supplementary Figure 2 from Adipocyte-Derived Fibroblasts Promote Tumor Progression and Contribute to the Desmoplastic Reaction in Breast Cancer
Authors: Bochet Ludivine , Lehuédé Camille , Dauvillier Stéphanie , Wang Yuan Yuan , Dirat Béatrice , Laurent Victor , Dray Cédric , Guiet Romain , Maridonneau-Parini Isabelle , Le Gonidec Sophie , Couderc Bettina , Escourrou Ghislaine , Valet Philippe , Muller Catherine
Published: April 2023

PDF file, 65K, Mature adipocytes dedifferentiation is not associated with changes in cell number or cell cycle distribution.
Supplementary Figure 1 from Requirements for Aurora-A in Tissue Regeneration and Tumor Development in Adult Mammals
Authors: Pérez de Castro Ignacio , Aguirre-Portolés Cristina , Fernández-Miranda Gonzalo , Cañamero Marta , Cowley Dale O. , Van Dyke Terry , Malumbres Marcos
Published: April 2023

PDF file - 119KB, Consequences of Aurora-A genetic ablation in mouse fibroblasts.
Supplementary Methods, Figure Legends 1-7 from MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis
Authors: Ho Ming-Yi , Liang Shu-Mei , Hung Shao-Wen , Liang Chi-Ming
Published: April 2023

PDF file - 123K
Supplementary Figure 7 from MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis
Authors: Ho Ming-Yi , Liang Shu-Mei , Hung Shao-Wen , Liang Chi-Ming
Published: April 2023

PDF file - 254K, Knockdown of MIG-7 downregulates lung cancer metastasis in an experimental murine metastasis model
Supplementary Figure 6 from MIG-7 Controls COX-2/PGE2-Mediated Lung Cancer Metastasis
Authors: Ho Ming-Yi , Liang Shu-Mei , Hung Shao-Wen , Liang Chi-Ming
Published: April 2023

PDF file - 296K, MIG-7 upregulates lung cancer metastasis in an experimental murine metastasis model