bluuebunny/crossref_metadata_2025 huggingface dataset:
Ustanowienie operatora wyznaczonego na rynku pocztowym w świetle ustawy o doręczeniach elektronicznych
Authors: Chołodecki Mateusz
Published: September 2022

Ustawa o doręczeniach elektronicznych wprowadziła do porządku prawnego nowe rodzaje usług w postaci publicznej usługi rejestrowanego doręczenia elektronicznego i publicznej usługi hybrydowej. Świadczenie obu tych usług z mocy prawa powierza się operatorowi wyznaczonemu w rozumieniu ustawy Prawo pocztowe. Najpóźniej w roku 2025 regulator rynku pocztowego — Prezes Urzędu Komunikacji Elektronicznej (UKE) — będzie jednak zobowiązany przeprowadzić konkurs na operatora wyznaczonego z uwzględnieniem zmian wprowadzonych przez ustawę o doręczeniach elektronicznych. W konkursie tym oceniane będą dodatkowe wymagania związane z koniecznością świadczenia publicznej usługi rejestrowanego doręczenia elektronicznego i publicznej usługi hybrydowej. W artykule analizie poddano zatem nowe kryteria udziału w konkursie oraz przesłanki wyboru operatora wyznaczonego przez Prezesa UKE.
Umowa koncesji na roboty budowlane lub usługi — pomiędzy umową cywilnoprawną a publicznoprawną
Authors: Horubski Krzysztof
Published: September 2022

W artykule poruszono kwestię charakteru prawnego umowy koncesji na roboty budowlane lub usługi. Zwrócono uwagę na możliwości jej jednoczesnego określania mianem cywilnoprawnej oraz publicznoprawnej przy przyjęciu stosownych zastrzeżeń i wskazaniu na odpowiednią płaszczyznę — normatywną lub nauki prawa administracyjnego oraz publicznego prawa gospodarczego. Wnioski te znajdują uzasadnienie w fakcie przenikania się oraz wzajemnego oddziaływania dominujących zasad prawa publicznego (równe traktowanie, nakaz ochrony konkurencji) oraz zasad prawa prywatnego (ograniczona, ale nie wyłączona swoboda umów) w regulacji prawnej tytułowych umów.
Ensaios por uma curadoria ao avesso
Authors: Gogan Jessica
Published: September 2022

A obra de Lygia Clark – abertura ao outro, dissolução do artista, ênfase na imanência do ato, práticas híbridas e fronteiriças entre arte e clínica – continua a desafiar a instituição de arte no século 21 e os conceitos de arquivo e de curadoria e suas possíveis alternativas. Ao tecer alguns fios investigativos com o seu legado, este artigo propõe um caminhando “com” sua obra e prática, trazendo questões de reencenação, outras historiografias e o uso de sua arte como dispositivo clínico no mundo. Uma peneirada dentre muitas possibilidades de sua radicalidade para o presente. Ensaios por uma curadoria ao avesso na busca de uma outra institucionalidade, alicerçada na práxis, mais do que em edifícios, exposições e acervos.
Abstracionismo na produção áudio-visual
Authors: Corrêa Antenor Ferreira
Published: September 2022

O objetivo neste texto é refletir sobre o abstracionismo na criação áudio-visual. Identifica-se que o abstracionismo já recebeu considerável atenção dos estudiosos da pintura; porém, o assunto apresenta-se quantitativamente pouco explorado ao considerar a produção áudio-visual. Inicialmente, apresento uma revisão conceitual da própria noção de abstracionismo, tendo por base distintas compreensões que o termo obteve desde o início do século XX. A seguir, analiso algumas obras áudio-visuais com intuito de fundamentar a discussão poética e estética sobre a participação das concepções abstratas nesse domínio artístico. À guisa de conclusão, verifica-se a ampliação conceitual da noção mesma de abstracionismo, atingida por distintas estratégias técnicas e poéticas do áudio-visual abstrato, bem como a possibilidade do engendramento de uma distinta forma de percepção para essas obras.
Hubungan Moral Disengagement dan Kecenderungan Perilaku Ghosting dalam Kencan Online Tinder
Authors: Azura Ria Tata
Published: September 2022

ABSTRAK
Aplikasi Tinder memberikan pengguna kemudahan dengan fitur-fitur yang ditawarkan, misalnya terkait kemudahan mengakhiri hubungan dengan ghosting. Bagi ghostee, ghosting menjadi pengalaman pemutusan hubungan yang paling tidak diinginkan. Namun, beberapa studi menemukan ghostee yang juga melakukan ghosting dan membenarkan perilakunya. Penelitian ini memiliki tujuan eksplanatori untuk mengetahui hubungan moral disengagement dan kecenderungan perilaku ghosting dalam kencan online Tinder; dan eksploratori untuk menguji peran variabel gender dalam hubungan kedua variabel penelitian. Penelitian ini melibatkan 70 emerging adult (18-25 tahun) pengguna Tinder. Pengumpulan data menggunakan skala moral disengagement (α= 0,921) dan skala kecenderungan perilaku ghosting (α= 0,840). Hasil menunjukkan hubungan positif moral disengagement dan kecenderungan perilaku ghosting yang signifikan. Terdapat pula perbedaan kekuatan hubungan yang signifikan antarvariabel dimoderasi oleh gender (f2 = 0,783), dengan efek moderasi yang lebih tinggi pada laki-laki. Hasil ini dapat menjelaskan mengapa ditemukan ghostee yang menilai ghosting tidak pantas juga dapat melakukan ghosting.
Pengaruh Psychological Safety terhadap Job Engagement pada Karyawan dengan Leader Safety Commitment sebagai Moderator
Authors: Nurullah Muhammad Ridla , Handoyo Seger
Published: September 2022

Penelitian ini bertujuan untuk menguji pengaruh psychological safety terhadap job engagement karyawan yang kembali bekerja di kantor setelah periode WFH dengan leader safety commitment sebagai variable moderator. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Jumlah partisipan pada penelitian ini sebanyak 114 orang. Hasil analisis menunjukkan bahwa terdapat pengaruh yang signifikan antara psychological safety dan job engagement, dengan arah pengaruh yang positif (p=0,005). Pada penelitian ini juga ditemukan bahwa leader safety commitment tidak memoderasi pengaruh psychological safety terhadap job engagement (p=0,675). Selain itu, ditemukan juga bahwa leader safety commitment memiliki pengaruh secara langsung terhadap job engagement (p=0,000).
Hubungan Literasi Kesehatan Mental dengan Intensi Mencari Bantuan pada Mahasiswa
Authors: Azedarach Melia Rizke , Ariana Atika Dian
Published: September 2022

Literasi kesehatan mental masyarakat yang rendah menyebabkan kondisi kesehatan mental kurang dilaporkan dan tidak terdiagnosis. Hal ini meningkatkan gangguan yang tidak tertangani, morbiditas, mortalitas, peningkatan stres serta kasus bunuh diri. Ketidakmampuan seseorang dalam mengenali gangguan mental diduga berkaitan dengan berkurangnya kemungkinan mencari bantuan. Penelitian terdahulu menyatakan bahwa mahasiswa merupakan kelompok terendah dalam mencari bantuan. Oleh sebab itu, penelitian ini bertujuan untuk mengetahui hubungan antara literasi kesehatan mental dengan intensi mencari bantuan pada mahasiswa. Penelitian ini menggunakan pendekatan kuantitatif dengan metode survei. Sampel dalam penelitian ini meliputi 111 partisipan yang merupakan mahasiswa berusia antara 18-25 tahun di Indonesia. Pengukuran dalam penelitian ini menggunakan skala Mental Health Literacy (MHL) dan skala General Help-Seeking Questionnaire (GHSQ). Analisis dilakukan dengan uji korelasi Spearman's rho pada JAMOVI 2.3.0.0 for macOS. Hasil analisis pada penelitian ini adalah tidak ditemukannya bukti yang dapat mengonfirmasi keberadaan hubungan antara literasi kesehatan mental dengan intensi mencari bantuan (r=0,034; p=0,727).
A New Direction for Insan JPKM: Embracing Both International and National Relevances
Authors: Wardana Nido Dipo
Published: September 2022

English has become the lingua franca in scientific communication. Non-native researchers were even found to submit 60% of their manuscripts in English (Stockemer & Wigginton, 2019). A belief that English publications can increase the reputation of the authors was known as the primary motivation behind this publication preference. Indeed, English articles tend to obtain a higher number of citations (Di Bitetti & Ferreras, 2017). This might be because English renders publications accessible to more readers. Many institutional bodies (including universities) eventually encourage their researchers to publish their works exclusively in English (Márquez & Porras, 2020).
Enhancing big data for greentelligence across the production value chain
Authors: Agbozo Reuben Seyram Komla , Peng Tao , Cao Huajun , Tang Renzhong
Published: September 2022

The big data concept has been explosive, revealing, and transformative across manufacturing industries as it provides deeper insights into manufacturing operations for decision-making. However, big green data (BGA), a dedicated subset of big data, is not adequately structured for comprehensive sustainability analysis, particularly in smart factories. With our proposed green data balance (GDB), there will be accountability for each input and output composition in a production unit within the production value chain (PVC). Data will be exhaustively and accurately collected in each workshop to help uncover unknown issues in a production value chain while facilitating the development of sustainability metrics or index systems. Additionally, a structured big green data system will fuel “greentelligence”, using intelligent systems and technologies to speed up digitalization toward sustainable manufacturing by measuring, tracking, and minimizing adverse environmental impacts. Lastly, with the support of the cognitive intelligence data analytic system (CIDAS), real-time and near real-time comprehensive sustainability analytics can be performed, leading to Self-X metacognitive adjustments and corrective actions.
Efects of a S-Metolachlor Based Herbicide on Two Plant Models: Zea Mays L. And Lactuca Sativa L.
Authors: Silva Quenia Mara , Palmieri Marcel José , Andrade-Vieira Larissa Fonseca
Published: September 2022

Brazil is the number-one country in pesticide consumption, and corn is the second most cultivated crop in the country. Chemical control of weeds associated with corn cultivation is performed by application of herbicides with pre- and postemergence action, such as S-metolachlor. Currently, the toxicity of herbicides is a task of great concern. In this regard, the present study aimed to evaluate the effects of an S-metolachlor-based herbicide through bioassays with the plant model Lactuca sativa L. (lettuce) and Zea mays L. (maize). The herbicidal test solutions containing 7.5, 15, 30, 60, 120, 240, 360, 480, 600, and 720 mg L-1 of the active ingredient S-metolachlor were prepared from commercial products. Distilled water was used as a negative control, and aluminum was used as a positive control. Macroscopic analyses (germination and growth) were performed for the two species, and microscopic analyses (chromosomal and nuclear changes) were performed for L. sativa. Negative interference of the S-metolachlor-based herbicide on lettuce was observed for all macroscopic and microscopic parameters tested. In maize, there was no significant interference in germination; however, the herbicide interferes negatively in seedling development. In brief, the herbicide based on S-metolachlor has phytotoxic potential, just as discussed.
EVALUATION OF THE PHILOSOPHY FOR CHILDREN- P4C PROGRAM APPLICATIONS APPLIED IN EDUCATIONAL INSTITUTIONS IN TURKEY ACCORDING TO TEACHER'S OPINIONS
Authors: AKAN Ramazan , BİLGİN Asude
Published: September 2022

Yapay zekanın egemen olmaya başladığı günümüzde çocukların var olan olay, olgu ve durumlarla ilgili kavramlar geliştirirken sorgulaması ve tartışmacı bir tutum sergilemeleri çocukları anlamlı öğrenmeye taşımakta ve bilgilerin kalıcılığının sağlanmasını sağlamaktadır. Bu araştırmaya veri elde etmek amacıyla yapılan çalıştaydı Türkiye’deki eğitim kurumlarında uygulanan çocuklar için felsefe (P4C) program uygulamalarının öğretmen görüşlerine göre değerlendirilmesi amaçlanmıştır. Bu araştırmaya veri elde etmek amacıyla Eğitim kurumlarında “Çocuklar İçin Felsefe (P4C) Programı” uygulamalarına dönük yapılan çalışmaların belirlenerek ortaya çıkan açık alanlara yönelik stratejiler ile eylem ve faaliyet önerilerinin geliştirilmesi hedeflenmiştir. Bu araştırma durum deseni çalışması olup, örneklem seçiminde çoklu çeşitlilik kullanılmıştır.

Araştırma çalışma grubunu 2020-2021 eğitim öğretim yılında Türkiye’de uluslararası bir kongreye katılan farklı branşlardan oluşan gönüllü öğretmenler oluşturmaktadır. Araştırmada veriler üç gruptan oluşan, her bir grupta yer alan beş katılımcıdan oluşan toplamda on beş öğretmenin görüşleri doğrultusunda gerçekleştirilen çalıştay ile swot analizi ile bilgiler toplanmış ve alınan görüşler doğrultusunda betimsel analizi yöntemiyle çalışılmıştır. Öğretmen görüşlerinden oluşan doğrudan alıntılara yer verilmiştir. Bu araştırma konusu üzerinde öğretmenlerin yeterli düzeyde hizmet içi eğitime katılmamış olmaları, Çocuklar için Felsefe (P4C) uygulama sahası olarak alanda yeni bir yaklaşım ve uygulama çalışması olması bu bağlamda fiziki donanım ve materyal eksikliklerinin ihtiyacı karşılar nitelik ve nicelikte olmayışı, öğrenci ve öğretmenlerin sorgulamacı ve tartışmacı davranış sergilemede kendilerini ifade etmede özgür ve özgüvenli hissetmemiş olmaları yanlış anlaşılma kaygıları bu araştırmada karşılaşılan sorunlar olarak gözümüze çarpmaktadır. Buna karşın öğretmenlerin Çocuklar için felsefe yaklaşımını doğru soru sorma ve analizinin gerçekleştirilmesinin çocukta öz güven, sorgulama, yaratıcılık, eleştirel düşünme, işbirlikli ve özenli düşünme yönlerini desteklemesi nedeniyle öğrencide akademik başarı, öğretmenlerin mesleki gelişimleri açısından olumlu görüş bildirdiklerini, kendilerini geliştirme fırsatını verdiğini ve farklı bakış açısı kazandırdığını ifade etmişlerdir.
Science Production in The Context of Post Digital Theory: Notes For A Meta Convergence Approach Prioritizing Human
Authors: ULUTAŞ Birgül
Published: September 2022

Technological developments produced through physics-based scientific convergences, known as Convergence 1.0 in the twentieth century, took place in the shadow of the driving force of war. Radio, television, telephone, aeroplane, radar, and computer, which have become inseparable parts of human life today, are the products of these convergences. The twenty-first century is the age of biology-based convergences in scientific production, called Convergence 2.0. which includes cancer-fighting nanoparticles, viruses used for energy production, and proteins used in water filtration. Using scientific and technological advances in the name of human dignity and the best interests of human beings is as important as the production of science. While the wars in the world and the dramas caused by migration and environmental disasters continue; scientific and technological developments need to be addressed with a meta convergence approach, including philosophy and social sciences. The post-digital theory offers scientists an important framework with its unique concepts and analyses for such a meta convergence that will prioritise human beings. This research is an effort to think about the possibilities of meta convergence that preserves the best interests of human beings and carries them to future generations within the framework of the post-digital theory.
Perencanaan Dinding Penahan Tanah Tipe Gravitasi di Desa Mulyorejo Kecamatan Ngantang Kabupaten Malang
Authors: Suhudi Suhudi , Rahma Pamela Dinar
Published: September 2022

Struktur konstruksi yang dibangun untuk menahan tanah yang mempunyai kemiringan/lereng, di mana kemantapan tanah tersebut tidak dapat dijamin oleh tanah itu sendiri disebut dinding penahan tanah. Hujan yang sangat lebat di daerah hulu sehingga permukaan air sungai meningkat dan aliran menghantam dinding sungai dan akhirnya lereng sungai longsor. Terjadinya kelongsoran lereng sungai yang ada di ruas jalan Malang-Kediri, tepatnya di Desa Mulyorejo Kecamatan Ngantang sepanjang 9 meter dan tinggi 4,5 meter. Tujuan penelitian ini adalah merencanakan dinding penahan tanah tipe gravitasi yang stabil dan aman terhadap guling, geser dan daya dukung tanah. Metode yang dilakukan yaitu pengumpulan data primer dan sekunder untuk perencanaan dinding penahan tanah tipe gravitasi. Dimensi bangunan dinding penahan tanah dengan tinggi 7 meter, lebar pondasi 2,5 meter dan lebar atas 0,5 meter. Langkah selanjutnya dilakukan analisa stabilitas terhadap guling, geser dan daya dukung tanah. Hasil analisa menunjukkan bahwa stabilitas terhadap guling 5,87 > 1,5 (aman) dan stabilitas terhadap geser 4,72 > 1,5 (aman). Sedangkan daya dukung tanah dinyatakan aman dan kuat menahan beban di atasnya dan tidak terjadi penurunan. Rencana anggaran biaya yang diperlukan mencapai Rp. 482.887.930,-.
Analysis of Black Spot and Black Site the Highway in Tenayan Raya Pekanbaru City
Authors: Kudus Zaini Abdul , Alqodri Muhammad
Published: September 2022

Pertumbuhan segenap kegiatan manusia, bidang ekonomi, sosial dan politik semakin meningkat. Hal ini juga mempengaruhi bidang transportasi jalan raya dan teknologi juga bertumbuh dengan cukup pesat. Di sisi lain kemampuan masyarakat untuk memiliki kendaraan bermotor secara pesat mengakibatkan jumlah kendaraan yang melintasi jalan raya semakin meningkat dan tingkat kecelakaaan akan mengalami peningkatan juga. Tujuan utama penelitian adalah untuk menghitung dan mengetahui tingkat kecelakaan, titik black spot kemudian black site, dan karakteristik kecelakaan lalu lintas pada jalan raya di Tenayan dengan data dikelompokkan dan dianalisis terhadap 8 data kejadian kecelakaan selama 5 tahun (2014-2018) terhadap sekmen kilometer. Hasil Analisis menunjukkan bahwa jumlah kecelakaan lalu lintas delapan kasus kejadian kecelakaan lalu lintas, nilai Accident Rate tertinggi untuk Black Spot adalah 0,12 di Km 23 sedangkan Black Site memiliki nilai Accident Rate tertinggi 0,12 di Km 23. Jenis kendaraan yang terlibat akhir-akhir ini adalah truk/bus – sepeda motor, dengan tiga kejadian. Korban jiwa berjumlah 12 orang, yakni enam orang meninggal dunia, dua orang luka berat, dan empat orang luka ringan serta korban terbanyak berusia 36-40 dan 51-55 tahun. Faktor utama penyebab kecelakaan adalah faktor manusia. Pencegahan dan penanganan kecelakaan lalu lintas dilakukan dengan perbaikan jalan secara berkala, penambahan rambu-rambu dan sosialisasi agar masyarakat menaati peraturan lalu lintas.
Perhitungan Pergeseran Garis Netral Penampang Balok Kayu Jati dengan Menggunakan Program Matlab
Authors: Basuki Achmad , Saifullah Halwan Alfisa , Sugihantoro Sugihantoro , Rismunarsi Endang , Supriyadi Supriyadi
Published: September 2022

Material kayu dapat menjadi alternatif yang baik karena memiliki sifat yang reversible, renewable dan memiliki kekuatan yang dapat diandalkan sehingga umum digunakan sebagai bahan konstruksi. Kayu yang sering digunakan adalah kayu jati (Tectona grandis) karena memiliki daya tahan alami yang sangat tinggi. Pengujian material kayu umumnya memiliki kuat tarik yang lebih tinggi dibandingkan kuat tekannya. Tetapi kenyataannya, pada pengujian lentur, keruntuhan awal yang terjadi merupakan keruntuhan tarik. Hal itu dikarenakan adanya pergeseran garis netral pada saat mengalami beban lentur. Perhitungan pergeseran garis netral tidak memungkinkan jika dihitung secara langsung, sehingga dibuatlah aplikasi untuk menghitung pergeseran garis netral pada penampang balok kayu jati. Perhitungan dilakukan dengan menggunakan aplikasi MATLAB dengan menggunakan data sekunder dari penelitian sebelumnya. Dari hasil penelitian ini, mendapatkan nilai faktor konversi antara tegangan aksial dengan tegangan lentur adalah 1,9 untuk tarik, dan 1,2 untuk tekan sehingga didapatkan hasil pendekatan yang mirip dengan data eksperimental.
Interference Patterns Within a Circular Boundary
Authors: Korula Aswan
Published: September 2022

In this paper we conduct a simple experiment wherein we create a wave within a circular container and analyse the interference patterns generated by the reflections from the boundary. In doing so we observe constructive interference in positions where our current wave theory predicts noise. This peculiar result demonstrates that in the particular situation presented here, the velocities of a wave before and after reflection from a solid boundary, are unequal.
Inhibitory effect of TCF7L2 on pancreatic β-cell dedifferentiation via ERK/MAPK signaling pathway in diabetes
Authors: Wu Hui-Hui , Ma Qian-Wen , Liu Yi-Meng , Wu Xia , Wang Xuan-Chun , Lu Bin , Zhang Zhao-Yun , Wen Jie
Published: September 2022

Background
Transcription factor 7-like 2 (TCF7L2) variants seem to affect diabetes susceptibility through β-cell dysfunction, underlying basis of which has been considered to be β-cell dedifferentiation rather than apoptotic β-cell death. However，little is known about how TCF7L2 variation contributes to β-cell dedifferentiation and how pancreatic β-cell dedifferentiation changes during diabetes progression.
Methods
To clarify the effects of TCF7L2 on β-cell dedifferentiation and insulin secretion, MIN6 cells were transfected with TCF7L2 shRNA or lenti-TCF7L2 virus for 48h and then the degree of β-cells dedifferentiation and insulin concentrations in supernatant were measured respectively. To further determine whether the effects are mediated by ERK/MAPK signal pathway, MIN6 cells were administrated with ERK phosphorylation inhibitor U0126 prior to TCF7L2 shRNA virus transfection. Subsequently, changes of TCF7L2 expression and pancreatic β-cell dedifferentiation were measured respectively in db/db mice after 2, 6 and 10 weeks of ND or HFD feeding.
Results
Our present study demonstrated that stable shRNA-mediated knockdown of TCF7L2 significantly increased β-cell dedifferentiation and drastically decreased insulin secretion of MIN6 cells. The opposite results were observed following lenti-TCF7L2 virus transfection. Interestingly, TCF7L2 exerted an inhibitory effect on the activation of ERK/MAPK signal and the effects of TCF7L2 on β-cells dedifferentiation and insulin secretion were totally attenuated when the phosphorylation of ERK was blocked using its chemical inhibitor U0126. Additionally, the declined TCF7L2 expression in paralleled with sustained activation of ERK/MAPK signal and increased pancreatic β-cell dedifferentiation were observed simultaneously in db/db mice. All animals showed impaired glucose tolerance during intraperitoneal glucose tolerance tests.
Conclusion
The pancreatic β-cell dedifferentiation which mediated by ERK/MAPK signaling pathway might be the essential component of TCF7L2 variants to develop diabetes.
Enhancing Consumption of Sustainable Transportation: Determinants and Outcome of Consumer Engagement with Bike-Sharing Service
Authors: Waqas Muhammad , Najmi Arsalan
Published: September 2022

Bike-sharing service has become a popular sustainable means of transportation due to its direct impact on traffic congestion, energy consumption, the environment, and people’s quality of life. Existing literature suggests that sustainable consumption can be promoted by engaging consumers with green products. This study examined drivers and the outcome of consumer engagement with bike-sharing services based on the technology acceptance model (TAM). A survey was conducted to collect the data from the users of the bike-sharing service in Kuala Lumpur. Structural equation modelling was used to analyse the data and find the relationship between variables. The empirical analyses showed that perceived ease of use and perceived usefulness of the bike-sharing service positively impact all facets of consumer engagement with bike-sharing service, which subsequently influences the continuance usage intention of bike-sharing service. The findings of this study offer useful insights that could enhance the consumption of bike-sharing service. This study also offers some guidelines to transportation practitioners, policymakers, and urban planners regarding promoting healthy and sustainable travel behaviour among urban commuters through bike-sharing service.
m7G-related miRNA signature for prediction of prognosis in lung adenocarcinoma
Authors: Jiang Sujing , Shi YueLi , Xiao Mingshu , Wang Yongfang , Xu Zhiyong , Wang Kai
Published: September 2022

Background
N7-methylguanosine (m7G), one of the most conserved nucleotide modifications, presents in mRNA caps and internal sites of tRNAs and rRNAs. Previous data have demonstrated that abnormal m7G is associated with tumorigenesis. Notably, the expression of m7G’s regulators remains unknown in human cancers, especially in lung adenocarcinoma (LUAD). This study aimed to construct a prognostic signature based on m7G-related miRNAs in LUAD and to explore the potential association of the regulators with tumor immune microenvironment (TIME).
Methods
We used LUAD data from The Cancer Genome Atlas (TCGA) to establish a risk model based on the m7G-related miRNAs, and divided patients into high-risk or low-risk subgroups. A nomogram for predicting overall survival (OS) was then constructed based on the independent risk factors. In addition, we performed functional enrichment analysis and defined the immune landscape as well as drug response profile in the high-risk and low-risk subgroups.
Results
This study incorporated 28 m7G-related miRNAs into the risk model. The data showed a significant difference in the OS between the high-risk and low-risk subgroups. The receiver operating characteristic curve (ROC) predicted that the area under the curve (AUC) of 1-year, 3-year and 5-year OS was 0.781, 0.804 and 0.853, respectively. The C-index of the prognostic nomogram for predicting OS was 0.739. We then analyzed the immune landscape in the high-risk and low-risk subgroups. The data demonstrated significant differences in the estimated score, immune score, stromal score, immune cell infiltration and functions between the high-risk and low-risk subgroups. In addition, drug response analysis showed that low-risk subgroups may be more sensitive to tyrosine kinase inhibitor (TKI) and histone deacetylase (HDAC) inhibitors.
Conclusion
We successfully developed a novel risk model based on m7G-related miRNAs in this study. The model can predict clinical prognosis and guide therapeutic regimens in patients with LUAD. Our data also provided new insights into molecular mechanisms of m7G in LUAD.
Risk Factors for Catheter-Related Bloodstream Infection in Patients Undergoing Hemodialysis: A Systematic Review And Meta-Analysis
Authors: 李 瑛 , Hou lingyu , Shi Min , Ding xiaorong
Published: September 2022

Background: Catheter-Related Bloodstream Infection (CRBSI) is a common and life-threatening complication of hemodialysis, with high morbidity and mortality. This meta-analysis was performed to analyze the risk factors of CRBSI in patients undergoing hemodialysis.
Methods: The search process included the electronic databases of CNKI, WANGFANG, PubMed, EMBASE, the Cochrane Library, and Web of Science from inception to July 2021. The quality assessment of the included studies was conducted according to the Newcastle-Ottawa Scale (NOS). The Odds ratios (ORs) with corresponding 95% confidence intervals (95%CIs) were calculated to assess the strength of the association of risk factors with CRBSI using RevMan 5.4 software in the current study.
Results: A total of 23 pieces of literature were included in this study, counting a total of 10335 patients, including 1165 patients with CRBSI and 9170 patients without CRBSI. Meta analysis results showed that puncture times [OR=3.22, 95% CI (2.42, 4.27)], femoral vein catheterization (OR=1.69, 95%CI 1.38-2.08, P＜0.00001), catheter indwelling time (OR = 2.22, 95% CI 1.62-3.04, P < 0.0001), age (OR =1.69, 95%CI 1.49-1.91, P < 0.0001), diabetes mellitus (OR=1.92, 95%CI 1.71-2.15, P< 0.00001), dialysis time (OR = 2.89, 95%CI 1.82-4.59, P <0.0001), duration of hospitalization (OR =2.49, 95%CI 1.47-4.23,P =0.0006) and hypoproteinemia (OR =3.19, 95%CI 2.08-4.89, P＜0.0001) were risk factors for CRBSI.Conclusions: Catheter retention time, age, femoral vein catheterization, diabetes, hospitalization time and hypoproteinemia were risk factors for CRBSI in hemodialysis patients.
Long-lifetime water-washable ceramic catalyst filter for air purification
Authors: Kwon Hyuk Jae , Yang Dong Sik , Koo Min Seok , Ji Sang Min , Jeong Joonseon , Oh Sehyeong , Kuk Su Keun , Heo Hyeon-su , Ham Dong Jin , Kim Mi Jong , Choi Hyoungwoo , Lee Jong-Min , Shur Joong-Won , Lee Woo-Jin , Bin Chang-Ook , Timofeev Nikolay , Huiqing Wu , Wang Liming , Lee Taewoo , Jacob Daniel , Kim Jhoon , Lee Hyun Chul
Published: September 2022

Particulate matter (PM) and volatile organic compounds (VOCs) are recognised as hazardous air pollutants threatening human health1,2. Disposable filters are generally used for air purification despite frequent replacement and waste generation problems. However, the development of a novel regenerable and robust filter for long-term use is a huge challenge. Here, we report on a new class of facile water-washing regenerable ceramic catalyst filters (CCFs), developed to simultaneously remove PM (> 95%) and VOCs (> 82%) in single-pass by coating the inner and outer filter channels with an inorganic membrane and a Cu2O/TiO2 photocatalyst, respectively. The CCFs reveal four-fold increase in the maximum dust loading capacity (approximately 20 g/L) in relation to conventional filters (5 g/L)3, and can be reused after ten regeneration capability with simple water washing retaining initial PM and VOC removal performances. Thus, the CCFs can be well-suited for indoor and outdoor air purification for 20 years, which shows a huge increase in lifetime compared to the six-month lifespan of conventional filters. Finally, we believe that the development and implementation of CCFs for air purification can open new avenues for sustainable technology through renewability and zero-waste generation.
Impact of digital economy on ecological resilience of resource-based cities: Spatial spillover and mechanism
Authors: Tang Yan , Wang Yusu
Published: September 2022

The digital economy and the construction of ecological civilization are central issues in the sustainable development of resource-based cities, and the impact of the digital economy on the ecological resilience of resource-based cities deserves further consideration. This paper measures ecological resilience of 117 resource-based cities from 2011 to 2020 using the entropy weight TOPSIS method, and empirically investigates the impact and mechanism of digital economy on ecological resilience using the SDM model and intermediary effect model. The results show that: the ecological resilience of resource-based cities has a certain upward trend, with a stepwise distribution pattern from east to west. There is a significant positive correlation between ecological resilience of resource-based cities, showing the phenomenon of club convergence which is primarily dominated by H-H and L-L. The digital economy has a significant spatial spillover effect, which promotes ecological resilience in the local and adjacent regions. A mechanism analysis reveals that technological innovation plays a mediating role between digital economy and ecological resilience, with significant heterogeneity in region and growth cycle. Following the above findings, this paper proposes policy suggestions related to digital economy evolution and ecological resilience enhancement.
Why do small volcanic ocean islands collapse? Lessons from Santa Maria Island, Azores Triple Junction
Authors: Marques Fernando , Ribeiro Luisa , Costa Ana Cristina , Hildenbrand Anthony
Published: September 2022

Volcanic ocean island collapse is a gravitational process, therefore mass is a key variable. Based on this premise, islands much smaller than Hawaii are believed to be not prone to collapse. Here we show that they can collapse, and more than once, like in Santa Maria Island (Azores), 170 times smaller than Hawaii, as inferred from onshore data and new high-resolution bathymetry. Santa Maria sits on oceanic sediments hundreds of meters thick, the top of which is unconsolidated, water saturated and, therefore, soft. Numerical simulations indicate that, if the volcanic edifice is strong, it does not collapse, even if its base is weak. However, a relatively weak edifice can collapse over a weak base. We conclude that small volcanic islands can collapse when both the edifice and its base are weak. Our numerical simulations also indicate that, if the basal detachment only partially occupies the base of the volcano edifice (outer soft sediment ring less affected by pressure and temperature), the flank will only partially collapse. This could be the case of the Hilina Slump in the Big Island of Hawaii, because the large size of the edifice can produce high-grade metamorphism in the sediments at the core of the edifice’s base.
Perceived neighborhood environment walkability and health-related quality of life
Authors: Zhu Jiaqi , Kodali Hanish , Wyka Katarzyna , Huang Terry T.-K.
Published: September 2022

Background
Measures of the built environment such as neighborhood walkability have been associated with health behaviors such as physical activity, the lack of which in turn may contribute to the development of diseases such as obesity, diabetes, cardiovascular disease, and cancer. However, limited research has examined these measures in association with health-related quality of life (HR-QoL), particularly in minoritized populations. We examined the relationship between perceived neighborhood environment and HR-QoL in a sample of mostly Black and Latino residents in New York City (NYC).
Methods
This study utilized the baseline survey data from the Physical Activity and Redesigned Community Spaces (PARCS) Study among 1,252 residents [34.6% Black, 54.1% Latino, 80.1% female, mean(± SD) age = 38.8 ± 12.5) in 54 park neighborhoods in NYC. Perceived built environment was measured using Neighborhood Environment and Walkability Survey, and mental and physical HR-QoL was estimated using Short Form (SF)-12. Using factor analysis, we identified two subscales of neighborhood walkability: enablers (e.g., trails, sidewalks, esthetics) vs. barriers (e.g., high crime and traffic). In addition, we included a third subscale on neighborhood satisfaction. Generalized Estimating Equation models adjusted for demographics and BMI and accounted for the clustering effect within neighborhood. Multiple imputation was used to account for missing data.
Results
Mental HR-QoL was associated with barriers of walkability (β ± SE = -1.63 ± 0.55, p < 0.01) and neighborhood satisfaction (β ± SE = 1.55 ± 0.66, p = 0.02), after adjusting for covariates. Physical HR-QoL was associated with only barriers of walkability (β ± SE = -1.13 ± 0.57, p < 0.05).
Conclusions
Among NYC residents living in minoritized neighborhoods, mitigating negative aspects of the neighborhood environment may be more crucial than adding positive features in terms of HR-QoL. Our study points to the need to investigate further the role of the built environment in urban, minoritized communities.
The effects of combined spinal-epidural analgesia and epidural anesthesia on maternal intrapartum temperature: A randomized controlled trial
Authors: Yao Zhiping , Zhou Jingxin , Li Shuying , Zhou Wenqin
Published: September 2022

Background:Labor epidural analgesia has been suggested to be associated with intrapartum fever. We designed this study to investigate the effects of epidural analgesia and combined spinal-epidural analgesia on maternal intrapartum temperature.Methods:Four hundred healthy nullipara patients were randomly assigned to receive either epidural analgesia (EA group) or combined spinal-epidural analgesia (CSEA group). Maternal temperature was measured hourly after analgesia administration. The primary outcome was the incidence of maternal fever, and the secondary outcomes were the duration of analgesia, analgesia to full cervical dilation and analgesia to delivery. Neonatal outcomes and other basic labor events were also recorded.Results:Maternal temperature gradually increased with time in both analgesia groups during labor. However, the CSEA group had a lower incidence of maternal fever, and a lower mean maternal temperature at 5 h, 6 h, and 9 h after analgesia. In addtion, the CSEA group also had a shorter time of analgesia duration, analgesia to full cervical dilation, analgesia to delivery, and less dose of epidural local anesthetic than the EA group.Conclusion:Our findings suggest that combined spinal-epidural analgesia is associated with a lower risk of intrapartum fever than epidural analgesia.Trial registration:ChiCTR1900026606. Registered on 16/10/2019.
Relationship between toe standing test and cervical spondylotic myelopathy: a new clinical sign
Authors: Liu Lei , Song Feifei , Liu Guangpu , Ma Chao , Han Meng
Published: September 2022

Background
We have discovered a new phenomenon in clinical practice called the toe standing test (TST), which has never been described and reported before. Based on the correlation of the toe TST with the relevant clinical data of patients with cervical spondylotic myelopathy (CSM) to determine whether it can be used as a new sign for the CSM.
Methods
The clinical data related to patients who visited our hospital for spinal cervical spondylosis were retrospectively collected. The general data and demographic characteristics of the patients were counted. The location of compression, compression segment, cause of compression, continuity of cerebrospinal fluid signal, alteration of spinal cord signal, muscle strength of lower limbs, grip strength of both hands, muscle tone of both lower limbs, Hoffmann's sign, and cervical JOA score were counted. The results of TST in CSM patients were recorded. Patients were grouped according to whether their TST results were positive or not, and the general information and clinical data of the two groups were compared statistically.
Results
A total of 171 patients with CSM were included, with a mean age of 61.1053 ± 12.7395 years and a positive toe standing test rate of 45.029% (77/171). The CSM patients were divided into positive (n = 77) and negative groups (n = 94). The differences in cerebrospinal fluid signal continuity and cervical JOA scores between patients in different groups were statistically significant (P < 0.05). The differences in the results of the remaining observations were not statistically significant. The results of univariate regression analysis did not see the above-mentioned observables as risk factors.
Conclusion
TST is closely related to CSM, and patients with positive TST may have long-term compression of the cervical spinal cord. TST may be a new clinical sign of CSM, and combined with the cervical JOA score, this test can assess the severity of spinal cervical spondylosis.
Reliability and quality assessment of colorectal cancer content in video sites
Authors: Wen Hua , Lu Ning , li Qian , Cui Manli , Su Yuanyuan , Zhang Jie , Li jie , Fan ling , Quan Xin , Zhang Mingxin
Published: September 2022

Objective:To assess the content, reliability and quality of video information about colorectal cancer in video websites.
Methods: We searched for "colorectal cancer" on Youku, Tencent, Iqiyi, Bilibili, Watermelon, Douyin and Kwai, and studied the top 50 videos sorted by "relevance" in the search function, totaling 350 videos. Video characteristics and upload sources were recorded. Two independent gastroenterologists assessed the reliability and quality of the video information using the Global Quality Scale (GQS) and the DISCERN assessment tool.
Results: A total of 350 videos were analyzed. Note that a total of 350 videos were analyzed. The most common sources of uploads were public hospitals/medical colleges/doctors (45.8%), followed by independent health information websites (26.0%), medical advertisements/for-profit organizations (7.7%), individual users/patients (9.7%) and talk shows/TV programs (10.8%). Symptoms and diagnostic options (35.4%) were the most common video content, followed by general information (24.0%) and treatment (23.1%), lifestyle/diet habits (7.2%) and complications (10.3%) were the least common.Mean DISCERN and GQS ratings were 2.77 and 3.11, respectively. Videos uploaded by Public hospitals/medical schools/doctors were more reliable and of higher quality, with mean DISCERN and GQS ratings of 3.12 and 3.26, respectively. The average value of DISCERN score and GQS score is greater than 3 in the videos uploaded by Iqiyi, Bilibili and Watermelon.
Conclusion:Video websites are one of the main sources of colorectal cancer information on the Internet, but most of the content is of low to medium reliability and low to medium quality, with some risk of misinformation. Therefore it is especially important to upload high quality and optimal length video content. Meanwhile, organizations and personnel with medical professional background upload videos of higher quality, and they should be encouraged to actively participate in colorectal cancer video science.
Association between MHR and MAFLD: A Single-center Retrospective Study
Authors: Han Jing , Li Yawei , Guo Jinbo , Luo Yuxin , Zhang Baolian , Liu Hong , Zhang Xiaolan
Published: September 2022

Background
Metabolic dysfunction-associated fatty liver disease (MAFLD) has high incidences and is one of the major hepatic diseases. Chronic low-grade inflammation has been considered to be an important pathogenesis of MAFLD. Monocyte /HDL-C ratio (MHR) is a novel marker of inflammation and oxidative stress. This study attempted to explore the correlation between MHR and MAFLD.
Methods
This study enrolled a total of 705 adults with MALFD and 1,505 healthy subjects as the control group. All participants accepted the anthropometric and laboratory tests. MHR was acquired as monocytes count divided by high-density lipoprotein concentration. After adjusting sex, age, BMI, blood pressure, hepatic enzyme, uric acid, fasting glucose, triglyceride, LDL-C, smoking, hypertension, diabetes, hyperlipidemia, we analyzed the correlation between MHR and MAFLD.
Results
An increased MHR was identified in the MAFLD group, and MHR correlated with BMI, diabetes history, and metabolic abnormalities. Univariate and multiple logistic regression analysis showed that MHR was associated with MAFLD. After adjusting for potential confounders, a non-linear relationship was found between MHR and MAFLD, and the inflection point was 0.396 in the non-linear curve. On the left of the inflection point, MHR positively correlated with MAFLD (OR = 1.459, 95% confidence interval (CI): 1.196 to 1.781, p < 0.001). However, there was no obvious relationship on the right (OR = 0.934, 95% CI: 0.797 to 1.096, p = 0.403). Interaction analysis showed that the association between MHR and MAFLD was significant in people less than 60, non-obese, without a history of diabetes, and without severe metabolic abnormalities.
Conclusion
MHR increased in adults with MAFLD. MHR positively correlated with MAFLD when less than 0.396. Therefore, MHR could be used as a predictor of MAFLD.
Systems Pharmacology Dissection of Pharmacological Mechanisms of Xiaochaihu Decoction against human coronavirus
Authors: Xu Lvjie , Cai Chuipu , Fang Jiansong , Wu Qihui , Zhao Jun , Wang Zhe , Guo Pengfei , liu Ailin , Zheng Lishu
Published: September 2022

Background
Coronavirus disease 2019 (COVID-19) pandemic is still raging worldwide, while the treatment of human coronaviruses (HCoVs) infections remains limited. Qingfeipaidu decoction (QFPDD), formulated by four classical prescriptions, was the most widely used prescription for COVID-19 containment and exhibited positive effects in China. As one critical prescription in QFPDD, Xiaochaihu decoction (XCHD) could relieve the symptoms of fever, fatigue, anorexia, sore throat in TCM theory. To explore the role and mechanisms of XCHD against HCoVs, we presented an integrated systems pharmacology framework in this study.
Methods
We constructed a global herb-compound-target network of XCHD against HCoVs. Subsequently, multi-level systems pharmacology analyses highlighted the key regulatory proteins of XCHD, and revealed that XCHD may affect multiple biological functions related to HCoVs. We further applied network-based prediction, drug-likeness analysis, combined with literature investigation to uncover the key ani-HCoV constituents in XCHD, while in vitro HCoV-229E virus-induced cytopathic effect assay was carried out to verify our prediction. Finally, we proposed molecular mechanism hypothesis for these compounds against HCoVs via subnetwork analysis.
Results
Based on the systems pharmacology framework, we identified 163 XCHD constituents connecting to 37 HCoV-associated genes. And an integrated pathway comprising TLR signaling pathway, RIG-1-like receptor signaling pathway, cytoplasmic DNA sensing pathway, and IL-6/STAT3 pro-inflammatory signal transduction axis was further proposed, revealing the mechanism of action of XCHD against HCoVs. Through in vitro assay, several constituents (e.g. betulinic acid, chrysin, isoliquiritigenin, schisandrin B, and (20R)-Ginsenoside Rh1) in XCHD exerted good inhibitory activity against HCoV-229E virus.
Conclusion
Our work presented a comprehensive systems pharmacology approach to explore the molecular mechanism and effective substances of XCHD against HCoVs.
An Overview of the Signs and Symptoms of Pediatric Patients Hospitalized with COVID-19
Authors: Aghdam Mojtaba Kamali , Sadeghzadeh Mansour , Yeganeh Pegah Moharrami
Published: September 2022

Introduction:
Clinical symptoms and laboratory findings of Covid-19 in children are more diverse than in adults. The aim of this study is to determine the clinical and laboratory findings of covid-19 in hospitalized children.
Materials and methods
This cross-sectional descriptive study was conducted on 57 children aged 1 month to 12 years who were admitted with Covid-19, and their diagnosis were confirmed by PCR method from March 2020 to November 2021 in Mousavi Hospital of Zanjan, Iran. Demographic data, clinical and laboratory findings of patients were recorded, and relevant information was analyzed.
Results
In this study, 57 children with Covid-19, PCR positive, including 26 boys (45.6%) and 31 girls (54.4%) were evaluated. The most common clinical findings were fever, cough, respiratory distress, vomiting, diarrhea and seizures with fever in 45 (78.9%), 30 (52.6 ),24 (42.1%), 21 (36.8%) ,18 (31.5) and 6 (10.5%) patients respectively. The most common laboratory findings were increased AST and ALT in 50 (87.7%) and 24 (42.1%) patients. Increased CRP and ESR were found in 21 (36.8%) and 15 (26.3%) patients, respectively. Lymphopenia and thrombocytopenia were reported in 14 (24.5%) and 4 (7.07%) patients, respectively.
Conclusion
The most common clinical manifestations of covid-19 in children were fever and cough. The increase of liver enzymes, especially AST, was significant in hospitalized children, while lymphopenia and thrombocytopenia were not common in affected children.