bluuebunny/crossref_metadata_2025 huggingface dataset:
Rancang Bangun Sistem Personal Owncloud Storage untuk Arsip File Tugas Akhir Prodi Sistem Komputer Berbasis Raspberry Pi 3
Authors: Andriani Leni , Islamiyah Mufidatul
Published: November 2024

Penelitian ini membahas Implementasi sistem back up jalur data (load balance and failover) 2 ISP pada “HIMAKOST” dengan metode per-connection classifier berbasis mikrotik, dengan penelitian ini akan menampilkan hasil pengukuran ketika jaringan di himakost mengalami kendala lambat, putus dan solusinya.
Pada penelitian ini dari hasil kendala yang ada, dilakukan proses load balance menggunakan metode per-conncetion classifier yang fungsinya untuk menyeimbangkan beban traffic dan overload serta failover yang fungsinya untuk mem-backup data.
Dari hasil pengujian pengambilan sampel masing-masing 5 data dari load balance dapat diketahui bahwa hasil perbandingan monitoring beban traffic dan overload antara ISP-1 dengan ISP-2 serta penggabungannya memiliki perubahan yang signifikan, hal ini menunjukkan bahwa penerapan load balance di himakost berjalan dengan baik. Adapun pengujian failover, dilakukan pengujian dengan memutus masing-masing ISP dengan tujuan untuk mem-backup data dan terbukti keberhasilannya.
DATA-DRIVEN APPROACH TO AUTOMATED LYRIC GENERATION
Authors:   Department of Computer Technology, Anna University, MIT Campus, Chennai, India, Needhi Jeyadev , Prasath G Ram ,   Department of Computer Technology, Anna University, MIT Campus, Chennai, India, G Vishnu ,   Department of Computer Technology, Anna University, MIT Campus, Chennai, India, S Manokar ,   Department of Computer Technology, Anna University, MIT Campus, Chennai, India
Published: November 2024

This project leverages Recurrent Neural Networks (RNNs) to generate coherent and contextually relevant song lyrics. The methodology includes extensive text preprocessing and dataset creation, followed by the construction of a robust model featuring Embedding, Gated Recurrent Unit (GRU), Dense, and Dropout layers. The model is compiled and trained using the Adam optimizer, with checkpointing to monitor and optimize the training process. Upon successful training on a comprehensive lyrics dataset, the model is thoroughly evaluated and fine-tuned to enhance performance. Finally, the model generates new lyrics from a given seed, showcasing its ability to learn intricate linguistic patterns and structures, thereby offering a powerful tool for creative and original lyric composition
UNDERSTANDING WATER HARDNESS IN DELHI NCR
Authors:   General Manager Sales Ion Exchange India Ltd., Delhi, India, Singh Shembe Param Jeet , Dwivedi Aman ,   Training Manager/District Sales Manager Ion Exchange India Ltd., Delhi, India, Singh Rajbir ,   Training Manager/District Sales Manager Ion Exchange India Ltd., Delhi, India
Published: November 2024

Delhi/NCR Delhi has the lowest score of any major city in India for water quality to supply locals, according to a report by the “Centre for Testing conducted by the Bureau of Indian Standards (BIS) on the Bureau of Food Consumer Affairs”. Water here is hard water which impacts the everyday lives of consumers. Literature Review here examines the current hardness of water quality in Delhi/NCR region covering cities like Delhi, Ghaziabad, Noida, Greater Noida, Faridabad, Sonipat & Panipat Areas.
A PROTOTYPE TWO-WHEELER OIL HEALTH MONITOR
Authors:   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, P Sunitha , R E Margaret ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, Babu C S Suresh ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, M Ramya ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, Gowda S P Preksha ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, Bagum Saira ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India, S Sanjana ,   Department of Computer Science and Engineering Malnad College of Engineering Hassan 573201, India
Published: November 2024

In today’s world, the Internet of Things (IoT) represents a smart and dynamic approach, leaving a profound impact on the future of the automobile industry. The integration of IoT innovations across various sectors is catalyzed by emerging trends, driving the demand for an enhanced human lifestyle. The applications of IoT are diverse and extensive, with one compelling example being its implementation in the automobile industry to monitor engine lubricants in real-time. An IoT-based Engine Oil Monitoring (EOM) System has been developed to address this need, aiming to streamline processes and offer intelligent sensing solutions for maintaining optimal engine oil conditions. This system utilizes an Arduino Nano microcontroller along with sensor devices such as the Light Dependent Resistor (LDR) sensor for assessing oil quality, the LM35 Temperature sensor for monitoring temperature, and an Ultrasonic Sensor for measuring oil levels within the engine. The testing results are displayed on a connected unit, providing immediate feedback on the engine oil’s status. Experimental findings from the proposed EOM system, utilizing IoT networks, demonstrate its efficacy in diagnosing engine lubricant conditions efficiently. Through rigorous experimental analysis, the functionality of the EOM system has been validated under various scenarios, such as testing with different engine oils like the 10W-50 4T Scooter Engine Oil used in Honda Activa 125. Overall, the successful operation of the EOM system signifies a significant advancement in the automotive industry, promising improved maintenance practices and contributing to the overall efficiency and longevity of vehicles
EVALUATION OF BAMBOO REINFORCEMENT FOR STRUCTURAL SUSTAINABILITY
Authors:   Department of Civil Engineering Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, 515002, Sreevalli Chemuduri Jyoshna , C Shashidhar ,   Department of Civil Engineering Jawaharlal Nehru Technological University Anantapur, Ananthapuramu, Andhra Pradesh, 515002
Published: November 2024

Bamboo, a fast-growing and renewable resource, provides an appealing alternative to traditional construction materials, which frequently have a negative environmental impact. This study investigates the use of modelling approaches to assess bamboo reinforcement’s potential to improve structural sustainability. Bamboo reinforcement has the potential to reduce environmental impact, increase sustainability due to its renewable nature, and make structures lighter in weight, which is especially useful in earthquake-prone locations. Researchers used software not limited to such as ETABS, Staad Pro, and ANSYS to simulate and study the structural behaviour of bamboo-reinforced parts, including load estimates, stress distribution, and connection behaviour. This study intends to improve modelling tools for accurately representing bamboo-reinforced structures, analyse their performance under different loads, and compare them to traditional solutions. Finally, this work can help improve the understanding of designing and assessing bambooreinforced structures, optimise their performance, and promote sustainable construction techniques.
DEVELOPING A QUALITY CLASSIFICATION SYSTEM FOR ARECA NUTS USING MACHINE LEARNING
Authors:   Dept. of Master of Computer Application Vivekananda College of Engineering and Technology Puttur, India, M Sudheendra , Teggihalli Sanket M ,   Dept. of Master of Computer Application Vivekananda College of Engineering and Technology Puttur, India, H Neema ,   Dept. of Master of Computer Application Vivekananda College of Engineering and Technology Puttur, India
Published: November 2024

Areca nuts, sometimes referred to as betel nuts, are a major crop in India and are grown extensively in regions like Kerala, Assam, and Karnataka. modern image processing and methods for machine learning are applied by the Areca Nut Grading System project to raise the effectiveness and market value of areca nut grading. Accurate and reliable grading is a basic need that this method meets to be able to guarantee fair pricing and quality control in the agriculture sector. The study employs a comprehensive technique that begins with preprocessing and the collection of unique images of areca nuts from several classes, including Bazar Ulli, Bazar Chali, Bazar Fator, and Bazar Karikoka
COMPRESSION OF HYPERSPECTRAL IMAGE USING JPEG COMPRESSION ALGORITHM
Authors:   Department of ECE SJB Institute of Technology, Bengaluru - 560060, Karnataka, India, Bharadwaj Sujendra G , B Shruthi ,   Department of ECE SJB Institute of Technology, Bengaluru - 560060, Karnataka, India
Published: November 2024

This paper delves into the considerable challenges of working with hyperspectral images, which are notably large and multidimensional, with file sizes often surpassing hundreds of megabytes. Hyperspectral imaging captures light across a continuous range of wavelengths, providing detailed spectral information for each pixel. This rich dataset is invaluable for applications such as environmental monitoring, precision agriculture, mineral exploration, and medical diagnostics, where accurate spectral data aids in identifying materials and detecting subtle variations. However, the immense data volume not only strains storage and transmission resources but also requires efficient processing and analysis techniques to handle the high-dimensional data without compromising quality. Additionally, compression methods are essential to manage storage constraints and improve real-time usability, but they must balance data reduction with the preservation of spectral integrity for effective analysis and application.
ADVANCEMENTS AND EFFICIENCY OF SOLAR THERMAL HEATING SYSTEMS
Authors:   Department of E&TC ISBM COE, Nande, Pune, Maharashtra, India, Singh Neha , Longani Sitaram ,   Department of E&TC ISBM COE, Nande, Pune, Maharashtra, India, Pande Sandhya ,   Department of E&TC ISBM COE, Nande, Pune, Maharashtra, India
Published: November 2024

Solar thermal heating systems are a sustainable energy technology that harnesses solar energy for heating applications. This research paper reviews the design, operational principles, and efficiency of solar thermal systems while comparing different types of collectors and applications. Additionally, it discusses recent technological advancements, environmental benefits, challenges in widespread adoption, and future outlooks. Solar thermal systems offer significant potential in reducing carbon emissions and addressing global energy demands, making them a viable solution for both residential and industrial sectors.
Changes in Tissue Oxidative Metabolism Predict the Severity of Disorders in the System of Blood and Bone Marrow Cells in a Mouse Model of Type 2 Diabetes Mellitus
Authors: Stepanova O. I. , Klesov R. A. , Semenov Kh. Kh. , Alchinova I. B. , Cherepov A. B. , Metelkin A. A. , Karganov M. Yu. , Nikolskaya A. O. , Onishchenko N. A. , Basok Yu. B.
Published: November 2024

The progressive development of diabetes mellitus (DM2) in db/db mice is associated with three stages of impaired carbohydrate metabolism and redox processes. In db/db mice, the content of erythrocytes, hemoglobin, and leukocytes was found to decrease already in stage I of DM2. In the II and, in particular, III stages, an increase in platelets, percentage of neutrophils, monocytes, and eosinophils was observed, along with a decrease in lymphocytes. In the bone marrow of db/db mice, a decrease in the proportion of living cells and an increase in the number of damaged cells were determined already in stage I, but especially in stage III, mainly due to aponecrotic cells. Therefore, along with the progression of DM2 and a marked decrease in the effectiveness of redox processes, particularly in stage III, hematopoiesis processes are inhibited and disturbances in the ratio of neutrophil/lymphocyte cell populations increase. This indicates the development of severe hypoxia, activation of a systemic inflammatory reaction, and inhibition of reparative processes that create conditions for the development of dangerous complications.
Stress-Protective Properties of the APHC3 Peptide in an Elevated Cross-Shaped Maze Test in ICR Mice
Authors: Pavlov V. M. , Fedotova A. Yu.
Published: November 2024

TRPV1, which plays a key role in transmitting pain signals, is widely distributed in various tissues and cells, including the central nervous system. Activation or suppression of TRPV1 influences neuronal desensitization, pain signal transmission, and regulation of neurotransmitter systems. The APHC3 peptide, as a selective antagonist of TRPV1, is used to investigate the effects of blocking this channel in terms of anxiety and stress response in mice. The results of studies can indicate the influence of TRPV1 on the formation of emotional states. This study is important for understanding the impact of TRPV1 channels on stress in ICR mice, being promising for further research in the field of biomedicine and biomodeling.
Anxiolytic Properties of the TRPV1 Receptor Antagonist in a Dark/Light Chamber Test on ICR Mice
Authors: Fedotova A. Yu. , Pavlov V. M.
Published: November 2024

TRPV1, a key mediator of nociceptive signaling, is widely distributed in various tissues and cells, including the central nervous system. The regulatory activity of TRPV1 affects neural desensitization, pain transmission, and neurotransmitter systems. The use of the beneficial peptide APHC3 as a selective antagonist of TRPV1 is a method for studying the blocking of this channel at the level of anxiety and is a response to stress in mice. The findings improve our understanding of the influence of TRPV1 on the moderation of emotional states. This study has important implications for understanding the effects of TRPV1 on stress states in ICR mice and may also contribute to medical and biomedical research.
Drug-Induced Liver Damage when Using Cephalosporins
Authors: Zamlelaya I. V. , Safronenko A. V. , Sukhorukova N. V. , Kapliev A. V. , Krishtopa A. V. , Khrkhrian S. S.
Published: November 2024

For many years, cephalosporins have been rarely reported as drugs causing hepatotoxicity. However, the recent data points to the possible development of various types of drug-induced liver damage associated with cephalosporins, including long-term ones, which manifest themselves 1–3 weeks after a single administration.
Assessment of the Effect of A1166C Polymorphic Marker of Angiotensin II Type 1 Receptor Gene (AGTR1) on the Dynamics of Daily Blood Pressure in Patients with Stage 1–2 Arterial Hypertension
Authors: Rebrova E. V. , Shikh E. V.
Published: November 2024

Differences in the response to pharmacotherapy with angiotensin II receptor blockers may be determined by polymorphisms in the genes responsible for their target of action. In this work, we investigate the pharmacodynamic parameters of daily blood pressure monitoring (DBPM) to assess the efficacy of therapy with angiotensin II receptor blockers in the form of monotherapy and as part of combination therapy in patients with arterial hypertension, depending on their genetic characteristics, i.e., polymorphism A1166C of the angiotensin II type 1 receptor gene (AGTR1). The study included 179 patients in the Moscow Oblast with newly diagnosed arterial hypertension of 1–2 stages. Among them, 141 (78.8%) were women and 38 (21.2%) were men aged 32 to 69 years, randomly assigned to irbesartan and valsartan groups in the form of mono- or combination therapy with hydrochlorothiazide by a simple randomization method. Following three weeks of pharmacotherapy, the presence of the rs5186 (A1166C) genetic polymorphism of AGTR1 gene was determined. DВPM was performed when patients were included in the study and after three months of therapy. The maximum antihypertensive effect was observed in heterozygotes A/C in the group of patients taking valsartan after three months of prescribed angiotensin II receptor blockers pharmacotherapy. This effect was manifested in a decreased average daily systolic blood pressure (SBP) and diastolic blood pressure (DBD), average night SBP, variability of night SBP and DBP. Among patients treated with irbesartan, there was no statistically significant association of the A1166C polymorphism genotype of the AGTR1 gene with these indicators. Heterozygotes showed a statistically significantly more pronounced decrease in the average sleeping heart rate in the group of valsartan patients. At the same time, the average daily heart rate decreased more significantly in C/C homozygotes in both the group of irbesartan and valsartan patients. Thus, when developing personalized treatment plans for patients with newly diagnosed stage 1–2 arterial hypertension using detection of the A1166C genetic polymorphism of the AGTR1 gene, it is advisable to recommend valsartan as a more effective initial therapy with angiotensin II receptor blockers in the form of mono- or combination therapy depending on the risk group for patients in the Moscow Oblast who are carriers of the A/C genotype.
Orthotopic Model of Human Glioblastoma
Authors: Goryacheva N. A.
Published: November 2024

The tumorigenic potential of A172, U251, and U87 glioblastoma cells has been studied in mice of the NODscid line.
Creation of a Synergistic Symbiotic Based on the Consortium of Lactobacilli Limosilactobacillus fermentum 3872, Ligilactobacillus salivarius 7247, and the Actigen Prebiotic for Salmonellosis Prevention in Humans and Farm Animals
Authors: Manoyan A. M. , Machulin A. V. , Papazyan T. T. , Ivanova O. E. , Panin A. N.
Published: November 2024

Salmonella enteritidis (SE), referred to nosocomial infections, colonizes the intestines of chickens and pigs. This leads to food contamination and increased risk of pathogen transmission to humans along the food chain. Multidrug-resistant (MDR) SE strains are particularly dangerous for newborn children and young farm animals. The antibiotics traditionally used for the treatment of salmonellosis disturb the balance of the intestinal microbiota. The development and use of synergistic synbiotics is a promising preventive direction in limiting the spread of salmonella infection. Synergistic synbiotics combine prebiotics and probiotics, which thus function optimally. The role of synbiotics in the prevention of SE remains to be elucidated. The aim of this study was to create a synergistic synbiotic with bactericidal activity and anti-adhesive properties against salmonella. As a result of the conducted research, an innovative synergistic synbiotic was created. This preparation comprises a consortium of probiotic strains of lactobacilli L. fermentum 3872 + L. salivarius 7247 and the Actigen prebiotic (a fragment of the cell wall of S. cerevisiae). In vitro experiments revealed that the consortium has a pronounced bactericidal effect on MDR SE. The culture fluid of the consortium, together with the Actigen prebiotic, is active and exhibits synergistic anti-adhesive properties against MDR SE. Further studies will apply the results obtained for developing a protocol for preclinical studies of the created symbiotic in vivo on experimental animals.
Experimental Models for Screening First Aid Medications for Convulsive Syndrome of Obscure Etiology
Authors: Melekhova A. S. , Ivnitsky Yu. Yu. , Krasnov K. A. , Belskaya A. V.
Published: November 2024

Three experimental models suitable for screening first aid medications for seizures of obscure etiology are developed. Hypobaric exposure in a pressure chamber at an “altitude” of 12 km, intraperitoneal administration of a 50% N-methylpyrrolidone solution of camphor in a volume of 2 ml/kg, or an aqueous solution of ammonium acetate in a dose of 770 mg/kg were used to induce convulsions in rats. Seizure latency time and lethality are proposed as necessary and sufficient criteria for assessing the effectiveness of tested pharmaceuticals. The developed models make it possible to evaluate the efficacy of potential anticonvulsants in the mode of emergency prevention or seizure relief. Due to the versatility of the neurotoxicity pathways of the convulsive agents, these experimental models are suitable for identifying anticonvulsants that are effective in convulsive syndrome of obscure etiology.
Modification of Rat Cardiovascular System Parameters in an Ischemia-Reperfusion Model Using Extremely High Frequency Electromagnetic Radiation
Authors: Ravaeva M. Y. , Cheretaev I. V. , Chuyan E. N. , Nagorskaya M. V. , Galenko-Yaroshevskii P. A. , Zelenskaya A. V. , Mironyuk I. S. , Dzeldubaeva E. R.
Published: November 2024

The article presents the results of studying the parameters of the cardiovascular system (CVS) in rats under conditions of ischemic-reperfusion simulation and exposure to electromagnetic radiation of extremely high frequency (EHF EMR). The aim was to identify changes in CVS parameters in rats during the postischemic period following preventive EHF exposure. The experiment was carried out on 30 mature male Wistar rats weighing between 200 and 220 g, which were housed in a vivarium under a natural light-dark schedule. Using a modified block randomization method, the animals were split into three groups with 10 rats in each: group 1 included sham-operated (SO) animals, which underwent surgery according to the operation plan but without occlusion of the left carotid artery; group 2 included truly operated animals who underwent surgery and had the left common carotid occluded (CCO) in accordance with the plan; and group 3 (EHF) included animals that underwent preventive 10-fold action of low-intensity EHF EMR followed by ischemia-reperfusion modelling (on the 10th day, after 60 min after the 10th session of EHF exposure) and OCA occlusion. It is shown that the modelled ischemia-reperfusion of the brain is associated with a strain of the physiological reserves of the CVS and the body as a whole. Thus, an increase in systemic blood pressure, heart rate, sympathetic effects on the CVS, energy costs, and oxygen consumption by cardiomyocytes is observed. Recovery of CVS indicators to the level of SO is observed on the 3rd day after ischemia. It was found that preventive 10-fold exposure to EHF mitigates the effect of ischemia, which is reflected in a decrease in all CVS indicators (except for PP). This increases adaptive capabilities of the body and accelerates recovery in post-ischemia, as well as promotes faster adaptation of physiological reserves to ischemic damage.
A Short Proof of Knuth’s Old Sum
Authors: Adegoke Kunle
Published: November 2024

We give a short proof of the well-known Knuth’s old sum and provide some general- izations. Our approach utilizes the binomial theorem and integration formulas derived using the Beta function. Several new polynomial identities and combinatorial identities are derived.
Phototherapy as an alternative in the treatment of chronic spontaneous urticaria
Authors: Giustozzi María Inés , Torre Ana Clara , Ritchie Carla , Parisi Claudio Alberto Salvador
Published: November 2024

Chronic spontaneous urticaria (CSU) is defined as the occurrence of hives, angioedema, or both, lasting for more than 6 weeks. The treatment is based on the use of antihistamines, omalizumab, and/or cyclosporine following a stepwise algorithm recommended by international guidelines with a high level of evidence. Nevertheless, management can be challenging as some patients do not respond to the suggested drugs or have difficulties accessing them for various reasons. In such cases, phototherapy has been reported as a potential treatment option. The evidence on the effectiveness of phototherapy is limited. Most studies have methodological limitations and involve small numbers of patients. A systematic review and meta-analysis of four studies in 2020 concluded that, despite the limited number of randomized controlled trials and the low level of evidence, considering overall efficacy, risk/benefit balance, and costs, narrow band ultraviolet B therapy (NB-UVB) may be a useful adjunct therapy for CSU. Other studies have suggested that the effectiveness of combined antihistamine and phototherapy appears to be more effective than antihistamine alone, although this is based on very low-quality evidence. Additionally, the risk of recurrence was lower with the combination therapy. The objective of this review was to evaluate the role of phototherapy in the treatment of CSU. While randomized studies with a larger number of participants providing a high level of evidence are still needed, we consider phototherapy to be a valuable tool in specific clinical contexts, such as a bridge to the initiation of other medications or until spontaneous remission of the condition occurs.
Common pollen and related allergen components in patients with allergic diseases in the Beijing area
Authors: Hou Yi-Bo , Sun Jin-Lu
Published: November 2024

Background

Pollen is the most common outdoor allergen that causes allergic rhinitis and asthma, which seriously affects patient quality of life and extensive cross-reactivity occurs between pollen allergens.

Methods

The study enrolled 84 patients with respiratory allergies and at least one pollen allergy who visited the clinic. Specific-IgE was detected via immunoblotting in the sera of patients with positive respiratory allergies to pollen. IgE of the components and cross-reactive carbohydrate determinants (CCD) were evaluated using a fluorescence-encoded microsphere assay.

Results

Our results suggest that Artemisia absinthium, Artemisia vulgaris, Humulus scandens, Amaranthus, Parietaria micrantha allergies are most common in the northern region, and that weed pollen remains the major pollen allergen in the northern region. Among the different age groups, the positive rate of Platanus pollen allergens was significantly higher in patients ≤18 years of age than in those aged >18 years (55.56% vs. 9.17%, χ² = 0.55, p < 0.027). Patients with allergic rhinitis and asthma had an increased positive rate for Betula pollen allergen (20.00% vs. 37.93 χ² = 7.87, p = 0.005) and Platanus pollen allergen (27.27% vs. 51.72%, χ² = 11.05, p = 0.0008) than those with allergic rhinitis alone, although the allergen positivity rate did not significantly differ between sexes. In addition, the positivity of sIgE of allergen components did not reveal a correlation with clinical symptoms and anti-CCD IgE positivity was 1.19% (1/84) among all patients.

Conclusion

The study found the distribution characteristics of common pollen allergens in Beijing among patients of different ages and genders and with different allergic diseases, as well as the relationship between pollen allergen components and symptoms. The positivity rate of CCD for respiratory allergic diseases in Beijing was not high as well.
Exploring the shared pathogenic mechanisms of tuberculosis and COVID-19: emphasizing the role of VNN1 in severe COVID-19
Authors: Sun Peng , Wang Yue , Zhou Sijing , Liang Jiahui , Zhang Binbin , Li Pulin , Han Rui , Fei Guanghe , Cao Chao , Wang Ran
Published: November 2024

Background

In recent years, COVID-19 and tuberculosis have emerged as major infectious diseases, significantly contributing to global mortality as respiratory illnesses. There is increasing evidence of a reciprocal influence between these diseases, exacerbating their incidence, severity, and mortality rates.

Methods

This study involved retrieving COVID-19 and tuberculosis data from the GEO database and identifying common differentially expressed genes. Machine learning techniques, specifically random forest analysis, were applied to pinpoint key genes for diagnosing COVID-19. The Cibersort algorithm was employed to estimate immune cell infiltration in individuals with COVID-19. Additionally, single-cell sequencing was used to study the distribution of VNN1 within immune cells, and molecular docking provided insights into potential drugs targeting these critical prognosis genes.

Results

GMNN, SCD, and FUT7 were identified as robust diagnostic markers for COVID-19 across training and validation datasets. Importantly, VNN1 was associated with the progression of severe COVID-19, showing a strong correlation with clinical indicators and immune cell infiltration. Single-cell sequencing demonstrated a predominant distribution of VNN1 in neutrophils, and molecular docking highlighted potential pharmacological targets for VNN1.

Conclusions

This study enhances our understanding of the shared pathogenic mechanisms underlying tuberculosis and COVID-19, providing essential insights that could improve the diagnosis and treatment of severe COVID-19 cases.
An index-based holistic approach to evaluate flood preparedness: evidence from Bangladesh
Authors: Rahman Md. Mostafizur , Islam Md. Rakibul , Shobuj Ifta Alam , Hossain Md. Tanvir , Ahsan Md. Nasif , Alam Edris , Al Hattawi Khawla Saeed , Islam Md. Kamrul
Published: November 2024

Introduction

This study aims to assess individual flood preparedness in the flood-prone Islampur Union of Sunamganj District, Bangladesh, using an index-based Holistic Individual Preparedness Model (HIPM).

Methods

A total of 510 respondents participated in a face-to-face field survey, which employed 21 flood preparedness indicators. The key objectives were to evaluate the extent of individual preparedness and its determinants. Statistical methods such as multiple linear regression and Spearman’s rank correlation were used to analyze the relationship between preparedness and various sociodemographic factors.

Results and discussion

The results show that 91% of respondents felt insecure during floods and 86% experienced damage to their homes. A significant proportion (87%) rated flood warnings as inadequate, while 84% did not seek refuge in flood shelters. Notably, 54% of respondents demonstrated limited knowledge of flood preparedness measures. Factors like gender, housing type, monthly income, and evaluation of flood warnings were associated with preparedness levels, with females and residents of kacha (unsafe) houses being less prepared. The study underscores the need for targeted campaigns and educational initiatives to improve preparedness, particularly for vulnerable groups.
The association between stress hyperglycemia ratio with mortality in critically ill patients with acute heart failure
Authors: Ge Tingai , Hu Jingjing , Zhou Yidan
Published: November 2024

Background

It's recognized that stress hyperglycemia ratio (SHR) is considered a significant indicator of poor prognosis in many diseases. However, its role in critically ill patients with acute heart failure (acute HF) remains underexplored.

Methods

We conducted a retrospective cohort study on patients with acute HF included in the Medical Information Mart for Intensive Care IV (MIMIC-IV) version 2.2 database. A restricted cubic spline (RCS) regression analysis was used to explore the relationship between SHR and the risk of all-cause mortality in these patients. Subsequently, a Cox regression model was used to evaluate the relationship between SHR and mortality in acute HF patients.

Results

A total of 1,644 acute HF patients were included in the study and divided into two groups: the low SHR group (SHR < 1.06, N = 823) and the high SHR group (SHR ≥ 1.06, N = 821). In our study, the 30-day, 90-day, 180-day, and 365-day mortality rates for acute HF were 7.0%, 12%, 15%, and 19%, respectively, with higher mortality rates observed in the high SHR group compared to the low SHR group. SHR levels showed a linear relationship with all-cause mortality. Furthermore, SHR as a continuous variable shows a significant positive correlation with 30-day (HR = 2.31, 95% CI: 1.58–3.39), 90-day (HR = 1.81, 95% CI: 1.31–2.52), 180-day (HR = 1.57, 95% CI: 1.16–2.12), and 365-day (HR = 1.41, 95% CI: 1.07–1.85) all-cause mortality. After categorization, high SHR remains associated with increased 30-day (HR = 2.4, 95% CI: 1.59–3.61), 90-day (HR = 1.76, 95% CI: 1.31–2.36), 180-day (HR = 1.51, 95% CI: 1.16–1.95), and 365-day (HR = 1.38, 95% CI: 1.09–1.73) all-cause mortality.

Conclusion

Our findings indicate that high SHR is an independent predictor of poor short- and long-term prognosis in acute HF patients. Understanding the impact of SHR on mortality in acute HF is crucial as it can assist clinicians in identifying high-risk patients and adjusting treatment strategies accordingly.
Communal and agentic teacher behavior in teacher-child dyads. A new self-report scale based on a circumplex approach
Authors: Kreutzmann Madeleine , Frühauf Madita , Hannover Bettina , Koeppen Karoline
Published: November 2024

Introduction

The goal of this study was to develop a self-report scale measuring the teacher’s interpersonal behavior in teacher-child dyads in elementary schools and to provide evidence of the scale’s validity. Using the framework of interpersonal theory, the Questionnaire on Dyadic Interpersonal Teacher Behavior (DITeB) models teacher behavior in an interpersonal circumplex that allows for the simultaneous analysis of teacher behavior along the two orthogonal dimensions of communion (warmth) and agency (guidance, monitoring).

Methods

We analyzed 440 dyadic teacher-child relationships derived from 88 teacher reports. Teachers rated the 20 items (8 scales) of the DITeB to describe their interpersonal behavior towards a child. To test the scale’s structural validity, we conducted confirmatory circumplex structural analyses. To test the scale’s construct validity, we used teachers ‘descriptions of relationship quality (closeness, conflict, dependency), and of their child related emotions (enjoyment, anger, anxiety). In addition, teachers reported on the child’s academic performance (numeric grades), as well as their professional beliefs about heterogeneity and self-efficacy for adaptive teaching, data which were used for further construct validation.

Results

We obtained empirical support for both structural and construct validity of the DITeB. Teacher interpersonal behavior correlated significantly with perceived relationship quality and emotions: high relationship quality and positive emotions were associated with high communion and low agency, whereas low relationship quality and negative emotions were associated with low communion and high agency, supporting construct validity. Additionally, as child’s academic performance improved, teachers’ agency decreased. Towards different groups of children, teachers’ interpersonal behaviors varied systematically based on their professional beliefs: teachers with strong heterogeneity beliefs tended to be more communal towards low-performing children compared to high-performing children. Moreover, teachers with strong self-efficacy towards adaptive teaching adjusted their agency more flexibly according to children’s performance in school, further supporting the construct validity of our instrument.

Discussion

We discuss how our instrument enriches the spectrum of existing scales on interpersonal teacher behavior. By focusing dyadic specific teacher behavior, the DITeB allows examining the extent to which the teacher adapts their behavior to child characteristics (adaptive teaching), and the effect of teacher behavior on child outcomes.
Empowering career pathways: integrating self-regulation strategies with career counseling practices
Authors: Rezaiee Mohsen , Kareshki Hossein
Published: November 2024

Introduction

This study explores the integration of self-regulation strategies into career counseling to enhance career development. It outlines the rationale behind this integration and sets the objectives of providing practical strategies for educators and counselors to support career paths.

Methods

The theoretical framework examines the role of self-regulation in career development and its intersection with career counseling in the modern workforce. Practical applications include self-regulation techniques for career advancement, career counseling interventions, and case studies.

Results

The application of these strategies is compiled into a resource manual, which includes tools, assessments, and activities for clients, as well as resources for career counselors. This manual serves as a practical toolkit for implementing the guide's recommendations.

Discussion

The conclusion highlights the contributions of the guide, reflecting on the integration of self-regulation and career counseling. Policy implications are discussed, with recommendations for education and workforce development, advocating for the institutionalization of self-regulation in career services. Future research and policy directions are suggested, emphasizing the importance of this integration for educational achievement and personal satisfaction. Overall, the guide offers a novel approach to career counseling, grounded in self-regulation theory and practice, providing a comprehensive resource for enhancing career pathways.
mRNA-based platform for preventing and treating Staphylococcus aureus by targeted staphylococcal enterotoxin B
Authors: Luo Fumei , Xu Chuanfei , Zhang Chengwen , Tan Aomo , Lu Dongshui , Luo Ping , Cheng Ping , Zhang Weijun , Bai Lijuan , Yu Cuiyun , Sun Si , Zeng Hao , Zou Quanming
Published: November 2024

Staphylococcus aureus (S. aureus) possesses numerous virulence factors, with the increasing prevalence of drug-resistant strains heightening the threat posed by this pathogen. Staphylococcal enterotoxin B (SEB), a highly conserved toxin secreted by S. aureus, is also recognized as a potential bioweapon with super-antigenic activity. SEB represents a promising target in efforts to combat infections caused by S. aureus. We developed mRNA-based vaccine and antibody targeting SEB for both prophylactic and therapeutic purposes in varying S. aureus infection conditions. The mSEB mRNA vaccine (10 μg per mouse) induces more robust and persistent immune responses, including higher antibody titers and specific cellular immune responses, compared to immunization with 30 μg of mSEB protein adjuvanted with aluminum phosphate. Additionally, the anti-SEB mRNA antibody maintains secretion of anti-SEB monoclonal antibody (mAb) with a dosage that is 10 times lower than purified protein administration. The mRNA-based antibody exhibits superior pharmacokinetic profiles compared to its protein counterparts, efficiently neutralizing SEB and clearing S. aureus from circulation. Both the mRNA vaccine and mRNA antibody demonstrate preventive and therapeutic effects by eliciting specific immune responses and generating high-affinity antibodies in mice. We have laid the groundwork for the development and evaluation of mRNA-based vaccines and antibodies targeting SEB produced by S. aureus. Our studies demonstrate that these approaches are more effective than traditional protein-based vaccines and antibodies in terms of inducing immune responses, pharmacokinetics, and their prophylactic or therapeutic efficacy against S. aureus infections.
Global trends and research hotspots in perioperative management of lung cancer: a bibliometric analysis from 2004 to 2024
Authors: Jiang Qinling , Wei Zhuheng , Liu Pingping , Li Zonghuai , Jiang Huiqin , Cao Yilin , Zhang Bo , Yan Yuanyuan , He Yulong
Published: November 2024

Objective

This article aims to analyze the current status and research hotspots of literature related to perioperative management of patients with Lung Cancer and provide reference for future research directions.

Methods

This study conducted a bibliometric analysis of research literature related to perioperative management of Lung Cancer published between 2004 and 2024, retrieved from the Web of Science database. R software and VOSviewer were used for analyzing keyword clusters and research themes, revealing trends and frontiers in this field.

Results

A total of 4,942 studies on perioperative management of lung cancer were included. In recent years, research in this area has shown a global upward trend, with particular focus on surgical risk assessment, complication prevention, and postoperative management. Perioperative biomarkers before and after surgery have emerged as a central focus due to their impact on diagnosis and treatment. The application of novel therapies, such as targeted drugs and immunotherapy, in perioperative management is also becoming a significant research hotspot. Additionally, China has been a leading contributor to research output in this field, demonstrating strong performance in international collaborations.

Conclusion

Perioperative management is a critical factor influencing the prognosis of Resectable lung cancer patients. Through a systematic analysis of the current status and research hotspots in perioperative management of lung cancer, this study provides valuable references for future clinical practice and research, particularly regarding the integration of novel therapies to optimize patient outcomes.
Coinfection of cytomegalovirus and strongyloidiasis presenting as massive gastrointestinal bleeding in an immunocompromised host: a case report
Authors: Huu Thanh Nguyen , Thu Hoai Mai , Quy Khoa , Thanh Mai Vo , Thi Nga Dinh , Ngoc Quang Pham Minh , Thi Tuyet Duong , Canh Binh Nguyen , Lam Tung Nguyen , Doan Ky Thai
Published: November 2024

Cytomegalovirus (CMV) infection is an opportunistic disease in immunocompromised patients that may appear without symptoms, with constitutional symptoms, or as a tissue-invasive disease. Strongyloides stercoralis infection often manifests with non-specific symptoms; however, it can lead to severe malabsorption and extraintestinal dissemination by accelerated autoinfection. The coinfection of CMV and Strongyloides stercoralis has rarely been reported, particularly with solely severe gastrointestinal bleeding. A 29-year-old female patient with a history of nephrotic syndrome treated with long-term corticosteroid and poorly controlled type 2 diabetes presented with a 20-day history of persistent epigastric pain, diarrhea, and significant weight loss. At the hospitalization, the patient appeared to have persistent gastrointestinal bleeding, leading to hypovolemic shock and diabetic ketoacidosis. Strongyloides stercoralis was detected by the duodenal biopsy results, and the polymerase chain reaction of these samples was positive for CMV. The patient underwent upper endoscopy four times to control the bleeding and was treated with ivermectin and ganciclovir. The patient improved gradually and was discharged after 23 days of hospitalization. The coinfection of CMV and Strongyloides stercoralis causing massive gastrointestinal (GI) bleeding has been rarely reported. To the best of our knowledge, this is also the first case of coinfection of these pathogens in an immunocompromised patient complicated with hypovolemic shock caused by GI bleeding and diabetic ketoacidosis. Clinicians should have a high index of suspicion and test simultaneously CMV and Strongyloides stercoralis in patients with immunosuppression, other risk factors, or unexplained gastrointestinal symptoms.
Identification of Pantoea ananatis strain BCA19 as a potential biological control agent against Erwinia amylovora
Authors: Lee Jueun , Jung Won-Kwon , Ahsan S. M. , Jung Hee-Young , Choi Hyong Woo
Published: November 2024

In this study, we aimed to screen potential antagonistic microorganisms against Erwinia amylovora, the causal agent of fire blight. From 127 unknown bacterial isolates tested, 2 bacterial strains (BCA3 and BCA19) were identified to show distinct antagonistic activity against E. amylovora in agar plate assay. Phylogenetic analysis of the 16s rRNA sequence identified both BCA3 and BCA19 as Pantoea ananatis. Among these BCA19 showed 13.9% stronger antagonistic activity than BCA3. Thus we further characterized antagonistic activity of BCA19. Culture filtrates (CF) of BCA19 significantly inhibited the swimming and swarming motility of E. amylovora. Ethyl acetate and n-butanol extracts of CF of BCA19 exhibited antibacterial activity in disk diffusion assay. Furthermore, gas chromatography–mass spectrometry analysis of ethyl acetate and n-butanol extracts of CF of BCA19 identified antibacterial compounds, including indole and hexahydropyrrolo[1,2-a]pyrazine-1,4-dione. Importantly, indole inhibited growth of E. amylovora with IC50 value of 0.109 ± 0.02 mg/mL (~930.4 μM). Whole genome sequence analysis of BCA 19 revealed gene clusters related with siderphore, andrimid, arylpolyene and carotenoid-type terpene production. This study indicates that BCA19 can be used as a potential biological control agent against Erwinia amylovora.
Investigating the effect of cochlear implant usage metrics on cortical auditory-evoked potential responses in adult recipients post-implantation
Authors: Bogdanov Caris , Goulios Helen , Mulders Wilhelmina H. A. M. , Tavora-Vieira Dayse
Published: November 2024

Introduction

This study examines the effect of cochlear implant (CI) device usage metrics on post-operative outcomes in unilateral CI recipients. The primary objective is to investigate the relationship between CI usage frequency (average daily CI use) and duration (total years of CI use) on electrically evoked cortical auditory-evoked potential (eCAEP) response peak latency (ms) and amplitude (μV).

Methods

Adult CI users (n = 41) who previously exhibited absent acoustically evoked CAEP responses participated in the study. The peak latency and amplitude of eCAEP P1-N1-P2 responses were recorded, when present for the apical, medial, and basal test electrode contacts. CI duration was defined as the number of years between the date of CI activation and date that eCAEP testing was performed. CI usage frequency was defined as the average number of hours per day of audio processor use, which was recorded using the CI programming software.

Results

Overall, 27 participants (65.85%) exhibited detectable eCAEP responses across one or more electrode contacts. Among these, 18 participants (43.9%) elicited eCAEP responses at all three electrode contacts, while 7 (17.07%) showed responses at two contacts, and 2 (4.88%) at one contact. For the remaining 14 participants (34.15%), eCAEP responses were either absent or undetectable. CI usage frequency (average daily CI use [hours/day]) was captured for 32 (78%) of the participants (median 10.35 h/day, range 0.2–16 h/day). Participants with present eCAEP responses for the basal electrode (n = 14) showed significantly higher CI usage frequency (11.8 h/day, p = 0.026) compared to those with non-detectable responses (6.25 h/day). An association was found between higher CI usage frequency and reduced N1 (p = 0.002), P2 (p = 0.0037) and P1-N1 inter-peak (p = 0.015) response latency (ms). While CI duration (total CI use [years]) did not differ significantly between groups based on the presence of eCAEP responses, an association was found between greater CI duration and increased eCAEP response amplitude (μV) for the P2 (p = 0.008) and N1-P2 peak-peak (p = 0.009) response components.

Discussion

Additionally, most (65.85%) participants who previously exhibited absent acoustic CAEP responses developed eCAEP responses after consistent CI use and increased CI experience. These findings may suggest a potential for cortical plasticity and adaptation with consistent CI use over time. Recognizing the impact of device usage metrics on neural responses post-implantation enhances our understanding of the importance of consistent daily CI use. Overall, these findings contribute to addressing the variability among CI users, improving post-operative outcomes and advancing the standard of personalized care in auditory rehabilitation.