bluuebunny/crossref_metadata_2025 huggingface dataset:
Графолалия в поэтическом письме. Авангард — андеграунд — андернет
Authors: В. Фещенко
Published: November 2024

В статье рассматривается поэтический прием, который предлагается называть графолалией, — орфографически аномальные проявления языкового эксперимента в поэтическом письме. Анализируются орфографические девиации, алфавитные трансформации и другие аномалии в начертании рукописного, типографского или компьютерного текста в русскоязычной поэзии от авангарда до интернет-эпохи. В первой части статьи приводятся примеры поэтической графолалии (экспериментов с буквой и алфавитом) в текстах русского футуризма (Р. Якобсона, П. Филонова, И. Терентьева, И. Зданевича). Во второй части обсуждаются языковые примеры графолалического письма в поэзии андеграунда и неоавангарда (Е. Мнацакановой, А. Альчук, Л. Березовчук). Часть третья посвящена современным поэтическим опытам орфографического радикализма и экспериментализма в цифровой среде у таких авторов, как Н. Скандиака, И. Краснопер, С. Камилл, В. Недеогло). Рассмотренные практики разложения языка, поэтической афазии, графолалии и выхода в иноязычие направлены на уход от поэтических конвенций в сторону лингвистического андеграунда, своего рода «языка под языком».

The article examines a poetic technique that the author proposes to be called grapholalia — orthographically anomalous manifestations of a language experiment in poetic writing. Spelling deviations, alphabetical transformations and other anomalies in the style of handwritten, typographical or computer text in Russophone poetry from the Avant-Garde to the Internet era are analyzed. The first part of the article provides examples of poetic grapholalia (experiments with letters and alphabet) in the texts of Russian Futurism (R. Jakobson, P. Filonov, I. Terentyev, I. Zdanevich). The second part discusses linguistic examples of grapholalic writing in underground and neo-avant-garde poetry (E. Mnatsakanova, A. Alchuk, L. Berezovchuk). Part three is devoted to contemporary poetic experiences of orthographic radicalism and experimentalism in the digital environment by such authors as N. Skandiaka, I. Krasnoper, S. Kamill, V. Nedeoglo). The considered practices of language decomposition, poetic aphasia, grapholalia, and foreignisms are aimed at moving away from poetic conventions towards the linguistic underground, a kind of “language underneath language”.
«Поэзия — это я»: перформансы Бонифация / Германа Лукомникова
Authors: М. Павловец
Published: November 2024

Основной корпус произведений Германа Лукомникова (Бонифация) вполне может быть отнесен к области собственно вербальной поэзии, однако в большинстве произведений при их письменной фиксации актуализирована визуальная форма, а при чтении вслух — акустическая, так что векторы визуализации и аудиализации выводят ряд текстов за границы «собственно поэзии» в область поэзии перформативной. Отдельные свои тексты поэт прямо определяет как «стихотворения-перфомансы», подчеркивая при этом их поэтическую, а не сугубо акционную основу. При этом его поэтические перформансы являются пересборкой традиционных представлений об «авторстве», обеспечивая реципиенту встречу с реальным автором во всех его ипостасях — как в творческих проекциях, так и в буквальных, в том числе телесных проявлениях.

The main corpus of German Lukomnikov’s (Bonifacius’) works may well be attributed to the field of verbal poetry proper, however, in most works, when they are recorded in writing, the visual form is actualized, and when read aloud, the acoustic form, so that the vectors of visualization and audialization take a number of texts beyond the boundaries of “poetry proper” into the field of performative poetry. The poet directly defines some of his texts as “performance poems”, while emphasizing their poetic, rather than purely actionist basis. At the same time, his poetic performances are a reassembly of traditional ideas about “authorship”, providing the recipient with a meeting with the real author in all his hypostases — both in creative projections and in literal, including physical manifestations.
«Выцветшая звезда надежды»: художественный мир Ингеборг Бахман в свете социально-политических рефлексий Ханны Арендт
Authors: О. Коваль , Е. Крюкова
Published: November 2024

В статье тематизируются некоторые аспекты поэтического и прозаического наследия Ингеборг Бахман, одной из самых ярких фигур немецкоязычной литературной сцены второй половины ХХ века. Социально-критические мотивы ее творчества рассматриваются в контексте размышлений Ханны Арендт, признанного политического теоретика и исследовательницы тоталитарных режимов. Концептуальные построения Арендт, проецируемые на художественные тексты Бахман, позволяют обнаружить в произведениях австрийской писательницы определенную этическую программу, провозглашающую необходимость коренных изменений в обществе, где по-прежнему царит насилие.

The article discusses some aspects of the poetic and prose heritage of Ingeborg Bachmann, one of the brightest figures of the German-language literary scene of the second half of the 20th century. The socio-critical intentions of her oeuvre are analyzed in light of the works of Hannah Arendt, a renowned political theorist and researcher of totalitarian regimes. It is conceivable to identify a specific ethical program in Bachmann’s writings, announcing the need for fundamental changes in a society where violence still reigns. This ethical program can be found as a result of Arendt’s conceptual constructions being projected onto Bachmann’s literary texts.
Воспитывать философией, воспитывать к философии (к позднесоветским педагогико-философским инициативам)
Authors: М. Маяцкий
Published: November 2024

в статье рассматривается педагогическое измерение позднесоветской философии и особенно такие ее аспекты, как протрептические (в отличие от идеологизированных пропедевтических) книги по философии (например, евгения Богата), педагогические идеи Московского логического кружка, круга Э.в. ильенкова, философские стороны движения коммунаров. общим элементом этих феноменов была идея воспитания человека, способного не адаптироваться к уже существующему обществу, а обновить его сообразно с коммунистическими идеалами, созвучными с мировой культурой, тяга к которой выступала своего рода антиидеологической фрондой, в целом приемлемой в рамках брежневской доктрины культурности.

This article examines the pedagogical dimension of late-Soviet philosophy and especially such aspects of it as protreptic (as opposed to ideologised propaedeutic) philosophy books (e.g. by Evgeny Bogat), the pedagogical ideas of the Moscow Logical Circle, Evald Ilyenkov’s circle, and the philosophical aspects of the communards’ movement. The common element of these phenomena was the idea of educating a person capable not of adapting to the existing society, but of improving it in accordance with communist ideals, which were formulated as consonant with world culture, the longing for which acted as a kind of anti-ideological dissidence, soft enough to be accepted within the framework of the brezhnevian doctrine of culturality.
Некоторые дополнения к текстам Малевича о кино
Authors: С. Шпикер
Published: November 2024

В статье показано, что позднее фигуративное творчество Малевича 1930-х годов не следует рассматривать как ревизионистское «возвращение к фигуративности». Вместо этого предлагается серьезно отнестись к утверждению Малевича о том, что его поздние картины являются органическим продолжением его супрематического стиля, а не разрывом с ним. Статья рассматривает поздние картины Малевича на фоне более ранних работ художника о кино. В духе его утверждения о том, что супрематическая живопись не является живописью (в общепринятом понимании), в статье предлагается читать поздние картины художника как форму расширенной формы кино. Очевидно, что этот аргумент предполагает такое понимание кино, которое не проводит границу между живописью и кино на основе их технических различий — точка зрения, которая во многом соответствует взгляду Малевича.

The article shows that Malevich's later figurative work of the 1930s should not be viewed as a revisionist “return to figurativeness.” Instead, it is suggested that we take seriously Malevich's claim that his late paintings are an organic continuation of his Suprematist style, and not a break with it. The article examines Malevich's later paintings compared to the artist's earlier works on cinema. In the spirit of his contention that Suprematist painting is not painting (in the conventional sense), the article considers the artist's late paintings as an expanded form of cinema. Obviously, this argument presupposes an understanding of cinema that does not draw the line between painting and cinema on the basis of their technical differences — a view that is very much in line with Malevich's.
Realidades Formativas Desde las TIC en el Área de Historia
Authors: Palacios Carrillo Eliana , Velásquez Velásquez Ángela María
Published: November 2024

Este artículo sitúa la enseñanza con Tecnologías de la Información y Comunicación (TIC) en un marco teórico y paradigmático que sirve como referencia para comprender las dinámicas pedagógicas y las contribuciones del docente en el proceso educativo. Adoptando un enfoque cualitativo mediante el método documental, se logró la comprensión e interpretación de textos, contrastándolos con las realidades abordadas tanto a nivel contextual como teórico. Los hallazgos resaltan la urgencia de centrarse en la promoción de métodos que enfaticen una educación tradicional, con el propósito de abordar los desafíos actuales de la educación, orientada hacia la implementación de una enseñanza moderna fundamentada en argumentos didácticos y mediada por las tecnologías. Se concluye que las TIC no deben considerarse un fin en sí mismas, sino más bien como herramientas que pueden potenciar el desarrollo de habilidades críticas, creativas y reflexivas en los estudiantes. En este sentido, se destaca la importancia de promover habilidades intelectuales, afectivas y psicológicas que generen situaciones de aprendizaje relevantes para las realidades cotidianas.
«Kannst du’s wohl mit geschloßnen Augen denken?». La semantica del vedere nelle traduzioni italiane della «Pentesilea» di Kleist
Authors: Lozzi Giuliano
Published: November 2024

Starting from the centrality of the part played by the eye in Kleist’s work and, in particular, in Penthesilea, I propose to investigate how this field emerges from the Italian translations of the work. Supported by the instruments of Textsemantik (Greimas) and Texttheatralität (Poschmann) and following the comparative method (Utz), particularly significant passages from the tragedy are analysed which, in the light of this theme, pose interesting questions related to isotopy and can illuminate the differences between the translations.
Fekete-Szeg¨o and Second Hankel Determinant for a Certain Subclass of Bi-Univalent Functions associated with Lucas-Balancing Polynomials
Authors:   School of Engineering, Math,  Technology, Navajo Technical University,Crownpoint, NM 87313, USA, Abdulmtalb Abdulmtalb ,   School of Engineering, Math,  Technology, Navajo Technical University,Crownpoint, NM 87313, USA,   Mathematics and Statistics, Witchita State University, Witchita, KS, USA, Illafe Mohamed , Zeyani Abdelbaset
Published: November 2024

In this paper, a new subclass of bi-univalent functions linked to Lucas-Balancing polynomials is introduced. Bounds for the coefficients in the Taylor-Maclaurin series, denoted as |a2| and |a3|, are determined for these functions. The Fekete-Szeg¨o functional problems are also addressed, and bounds for the second Hankel determinant for functions in this specific subclass are established. Additionally, it is shown that by adjusting the parameters in the main findings, several new results can be derived.
НАПРАВЛЕНИЯ ИСПОЛЬЗОВАНИЯ ТЕХНОЛОГИЙ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА В HR-МАРКЕТИНГЕ И УПРАВЛЕНИИ ПЕРСОНАЛОМ
Authors: Е.Г. Новосельцева
Published: November 2024

В статье исследуются вопросы автоматизации HR-маркетинга и управления персоналом на основе искусственного интеллекта с целью повышения эффективности бизнес-процессов компании и адаптивности к изменяющимся рыночным условиям. Автором рассмотрена мировая и отечественная статистика, представлена типология искусственного интеллекта в управлении персоналом по видам выполняемых задач, определены направления использования алгоритмов искусственного интеллекта в сфере HR. Выделены риски, причины отказа и преимущества внедрения технологий искусственного интеллекта при управлении кадровым потенциалом на основе анализа практик автоматизации. Интеллектуальные технологии меняют экосистему управления персоналом, оптимизируют внутренние процессы и способствуют росту бизнеса.

The article explores the issues of automation of HR-marketing and staff management based on Artificial Intelligence in order to increase the efficiency of the company's business processes and adaptability to changing market conditions. The author analyzes world and domestic statistics, presents the typology of Artificial Intelligence in staff management by type of tasks performed, and defines the directions of using Artificial Intelligence algorithms in the field of HR. The risks, reasons for failure and advantages of the introduction of Artificial Intelligence technologies in human resource management based on the analysis of automation practices are highlighted. Intelligent technologies are changing the ecosystem of staff management, optimizing internal processes and contributing to business growth.
ТРАЕКТОРИИ РОСТА ЛОГИСТИКИ В СТРОИТЕЛЬНОЙ ОТРАСЛИ
Authors: В.В. Борисова , А.Н. Будяков
Published: November 2024

Актуальность статьи обусловлена важностью вопросов логистического обеспечения строительной отрасли, включая построение логистических систем. Исследование данных вопросов потребовало уточнения субъектно-объектного состава логистической системы и идентификации траектории ее развития в условиях санкционной агрессии в отношении российской экономики. Обоснована необходимость адаптации логистических систем к опасной и турбулентной внешней среде, реализуемой через быстрое и гибкое реагирование на возникающие вызовы и угрозы. Показано, что экологическая/углеродная повестка становится важным экономическим фактором безопасности и конкурентности логистической системы. Выделены точки роста и перспективы развития логистических систем в строительной отрасли. Сделан вывод, что новые технологии в строительной отрасли способны как повышать устойчивость логистической системы, так могут и разрушить ее.

The relevance of the article is due to the importance of the issues of logistics support for the construction industry, including the construction of logistics systems. The study of these issues required clarification of the subject-object composition of the logistics system in the context of sanctions aggression on the Russian economy and the identification of the trajectory of its development. The need to adapt logistics systems to a dangerous and turbulent external environment, implemented through a quick and flexible response to emerging challenges and threats, is substantiated. It is shown that the environmental/carbon agenda is becoming an important economic factor in the security and competitiveness of the logistics system. Growth points and prospects for the development of logistics systems in the construction industry are highlighted. It is concluded that new technologies in the construction industry can both increase the stability of the logistics system and can destroy it.
ПРИМЕНЕНИЕ РЕКОМЕНДАТЕЛЬНЫХ ТЕХНОЛОГИЙ ПЕРСОНАЛИЗАЦИИ КЛИЕНТСКОГО ОПЫТА В ОНЛАЙН-ТОРГОВЛЕ
Authors: И.С. Емельяненко
Published: November 2024

Статья посвящена исследованию вопросов применения рекомендательных технологий в онлайн-торговле с целью формирования уникального клиентского опыта. Выделены преимущества использования рекомендательных технологий в торговом маркетинге, представлены варианты внедрения блоков с персональными рекомендациями на сайт интернет-магазина. Выявлены виды рекомендательных блоков в зависимости от контента и типы товарных рекомендаций на основе персонализированных данных о предпочтениях, истории покупок и действиях потребителей. Сформирован алгоритм работы рекомендательных систем при заполнении онлайн-витрины интернет-магазина, включающий сбор сведений о пользователе, выбор товаров для товарной полки, расположение товаров, обеспечение разнообразия, отображение рекомендаций. Представлены результаты анализа эффективности персональных рекомендаций по просмотрам пользователями и количеству покупок в различных категориях интернет-магазинов.

The article is devoted to the study of the application of recommendation technologies in online trading in order to form a unique customer experience. The advantages of using recommendation technologies in trade marketing are highlighted, and options for implementing blocks with personal recommendations on the website of an online store are presented. The types of recommendation blocks depending on the content and types of product recommendations based on personalized data on preferences, purchase history and consumer actions have been identified. An algorithm for the operation of recommendation systems has been formed when filling out the online storefront, including collecting information about the user, selecting products for the product shelf, arranging goods, ensuring diversity, and displaying recommendations. The results of the analysis of the effectiveness of personal recommendations on user views and the number of purchases in various categories of online stores are presented.
ОПТИМИЗАЦИЯ СИСТЕМ ВОДОСНАБЖЕНИЯ НА ОСНОВЕ РИСК-ОРИЕНТИРОВАННОГО ПОДХОДА
Authors: В.И. Гиссин , К.Ф. Механцева , М.Н. Наливайко
Published: November 2024

В статье рассмотрены процессы жизненного цикла производства и распределения питьевой воды потребителям как предоставляемая услуга с последовательно связанными компонентами, определяющими безопасность потребления. Представлен процесс обеспечения качественной и безопасной водопроводной водой в виде модели, в которой рассмотрено влияние как внутренних, так и внешних воздействий, приводящих к возникновению рисков в системе. Проведен анализ причинно-следственных связей, выявивший причины возникновения рисков при водоснабжении питьевой водой, что позволило рекомендовать применение различного инструментария и методов оценки рисков. С целью уменьшения влияния рисков на качество процесса поставок предложено постоянно проводить причинно-следственный анализ рисков на всем пути перемещения водных ресурсов или использовать метод «пять почему», выявляющий коренные причины возникновения проблемы. Результаты исследований позволили рекомендовать применение анализа видов и последствий отказов на пути товародвижения питьевой воды от производства и до распределения, что даст возможность выявлять дефекты системы водоснабжения с последующим их устранением.

The article examines the life cycle processes of the production and distribution of drinking water to consumers as a service provided, with sequentially related components that determine the consumption safety. The process of providing high-quality and safe tap water is presented in the form of a model, which considers the influence of both internal and external influences leading to risks, which can appear in the system. An analysis of cause-and-effect relationships was carried out, which revealed the causes of risks in drinking water supply and made it possible to recommend the use of various tools and methods for risk assessment. In order to reduce the impact of risks on the water quality in the supply process, it is proposed to constantly conduct a cause-and-effect analysis of risks along the entire path of water resources movement or use the five whys method, which identifies the root causes of the problem. The research results made it possible to recommend the use of failure mode and effects analysis along the distribution way of drinking water from production to consumer, which will make it possible to identify defects in the water supply system and then eliminate them.
К ВОПРОСУ О РАЗВИТИИ ЦИФРОВЫХ КОММУНИКАЦИЙ В СОВРЕМЕННОМ DIGITAL-МАРКЕТИНГЕ
Authors: О.В. Иванченко , Е.В. Барауля
Published: November 2024

В статье рассматриваются вопросы развития инструментов маркетинговых коммуникаций в условиях цифровой трансформации рыночного пространства. Изменения рекламного рынка и прогресс информационных технологий открывают компаниям возможности для внедрения новых форматов digital-маркетинга при взаимодействии с целевой аудиторией. Представлена российская статистика цифрового рынка маркетинговых коммуникаций, интернет-рекламы и перспективных направлений цифрового маркетинга. Выделены тренды, влияющие на формирование омниканальной маркетинговой digital-стратегии. Определены актуальные инструменты реализации digital-маркетинга с целью формирования креативных и целевых кампаний, адаптированных к специфике отечественной аудитории.

The article discusses the development of marketing communication tools in the context of digital transformation of the market space. Changes in the advertising market and the progress of information technology open up opportunities for companies to introduce new digital marketing formats when interacting with the target audience. The Russian statistics of the digital market of marketing communications, Internet advertising and promising areas of digital marketing are presented. The trends influencing the formation of an omnichannel digital marketing strategy are highlighted. The relevant tools for the implementation of digital marketing have been identified in order to form creative and targeted campaigns adapted to the specifics of the domestic audience.
Delivery of differentiation therapy into solid tumor cancer stem-like cells to prevent metastasis and recurrence
Authors: Zhou Zezhi
Published: November 2024

Abstract. The concept of differentiation therapy offers an attracting explanation for plenty of clinical observations, such as relapse and metastasis. Its hallmark success has been in the treatment of acute promyelocytic leukaemia, a condition that is now highly curable through the combination of retinoic acid (RA) and arsenic. Recently, the finding of cancer stem-like cells (CSCs) triggers more attentions due to its unique high tumourigenicity and chemoresistance., which reside in hypoxic tumor regions, and are characterized by high tumourigenicity and chemoresistance. Considerable efforts have been made to develop promising anti-CSC strategies, including blocking surface biomarkers and inhibiting self-renewal signaling pathways. In this study, we engineered a liposomal delivery strategy that enables the codelivery of RA and arsenate, aiming to differentiate and potentiate CSCs. The core of the liposome is formed through coordination polymerization between arsenate and Calcium, while the membraneincorporates RA and helper lipids. We evaluated their cytotoxicity against cultured CSCs and their potential to differentiate CSCs into less malignant phenotypes.
Muscle growth: Mechanisms, impact on performance, and training strategies
Authors: Wang Haozhe
Published: November 2024

Abstract. The significance of muscles in physiological functions sparked a quest to understand how muscles grow in average individuals, the causes of muscle loss in the unwell, and the impact of muscles on athletes prowess. This paper delves into the intricacies of muscle growth, inspired by the experiences of renowned figures like Stephen Hawking and Cai Lei, both confronting the challenges of ALS. The paper addresses the fundamental question of how muscle growth occurs and explores the impact of different training methods on muscles and joints. It investigates the optimal repetition range for muscle growth, considering factors like tension, damage, and metabolic stress. Through extensive research, the paper establishes that muscle training can be achieved through various methods, each with its advantages and drawbacks. It challenges the traditional notion of the 6-12 repetitions optimal range for muscle growth and suggests that even with high repetitions, proximity to muscle fatigue can yield similar growth effects. The findings advocate for a balanced training approach within the 6-12 repetition range to promote muscle diversity while safeguarding joint health. The research recommends allocating the majority of training within this range (60%-70%) for optimal muscle mass increase, providing flexibility based on individual differences and health conditions.
Analysis of alleviating memory loss in Alzheimers disease
Authors: Li Yu
Published: November 2024

Abstract. There are two types of memory: prospective memory and retrospective memory. The capacity to recall future occurrences is known as prospective memory, whereas the recall of previous events is known as retrospective memory. Individuals with Alzheimers Disease (AD) typically exhibit a general memory decline. These patients are unable to recall past events and struggle to form new memories. A comprehensive review of a vast body of literature indicates that the recovery of retrospective memory poses a significant challenge and can only be treated through a few simple external stimuli, such as utilizing auditory or olfactory cues, which are familiar to AD patients, to stimulate the recall of relevant memories. In the current research landscape, there are limited options for the recovery of retrospective memory, whereas there are numerous treatments available for the improvement of prospective memory, including the administration of medications and techniques that can specifically target the condition, significantly enhancing the likelihood of recovery in patients.
A review of retinoblastoma on its discovery, genetic aspects, and treatments
Authors: Ma William
Published: November 2024

Abstract. Retinoblastoma, a critical early-childhood retinal cancer, poses significant challenges and opportunities for oncological research. This paper provides a comprehensive examination of Retinoblastoma, from its historical context and genetic underpinnings to contemporary diagnostic and therapeutic strategies. It delves into the pivotal role of the RB1 gene in the diseases hereditary and sporadic forms, underscoring the importance of genetic mutations and the potential of molecular genetics in advancing patient care. Through an analysis of current findings and treatment approaches, this study highlights the ongoing evolution in managing Retinoblastoma, emphasizing early detection, the exploration of genetic landscapes, and the development of targeted therapies. Future research directions are proposed, aiming at refining diagnostic accuracy and improving treatment outcomes, thereby offering hope for affected children and their families.
Insights on the clinical, genetic, and mutation risk factors underlying the prognosis of breast cancer using machine learning models
Authors: Chen Yundi
Published: November 2024

Abstract. Breast cancer is one of the most prevalent tumors in the world, making it essential to identify important features for the prognosis. Various methods, including statistical tests and machine learning, have been employed to capture relative attributes for survival prediction. However, most prior studies have focused solely on clinical factors, without considering genetic factors. In this study, a dataset comprising clinical features, gene expression, mutation attributes, and survival status of 1882 patients was involved to assess important features for breast cancer prognosis. Statistic tests were applied first to identify distribution differences and correlation significance among different features. Afterward, predictive models were trained. The results indicated that age at diagnosis, lymph nodes examined positive, and Nottingham prognostic index were the top three important features. Genes including HSD17B11, JAK1, and STAT5A, as well as mutations, including mutations in GATA3, TP53, and MUC16, also emerged as relative features. Additionally, Gradient Boosting Decision Trees outperformed three other models with an AUC-ROC of 0.75. These findings shed light on the further identification of not only important clinical attributes but also molecular markers for breast cancer prognosis.
The comparison between different therapies of Systemic Lupus Erythematosus
Authors: Yang Yening
Published: November 2024

Abstract. The immune system has three basic functions: defense, surveillance and homeostasis. It helps us monitoring and timely eliminate mutant cells and distinguishing between alien components to maintain self-stability. However, once it loses these abilities, it could cause the autoimmune disease. In this article, I mainly discuss about the Systemic Lupus Erythematosus (SLE), a type of autoimmune diseases which is mediated by type hypersensitivity. SLE patients suffer from chronic inflammatory responses, leading to tissue damage and organ dysfunction. Therefore, purpose of therapeutic schedule is to inhibit the overactive immune system and relieve the inflammatory response. Nowadays, there are three major therapies: Glucocorticoids (GC), immunosuppression agents and belimumab. Glucocorticoids suppresses inflammatory responses and generate anti-inflammatory factors. Immunosuppression agents can not only control SLE and raise the survival rate of long-term prognosis for SLE patients. Belimumab inhibits the survival of B cells by obstructing the interaction between soluble B cell activating factor (BAFF or BLys) and receptors on B cells. This action promotes the apoptosis of auto-reactive B cells, leading to a decrease in auto-antibodies present in the serum. With the development of biotechnology, more and more advanced treatments have emerged and brings new hope to SLE patients.
Utilizing deep learning for alzheimer's disease treatment: Targeting -amyloid for therapeutic intervention
Authors: Fang Tianrui
Published: November 2024

Abstract. Amyloid-beta (A for short) is a protein intricately linked to Alzheimers disease (AD for short). In the brains of AD patients, A forms abnormal deposits known as amyloid plaques, which are considered one of the key factors in the progression of AD. These plaques may disrupt communication between neurons, leading to cell death and a decline in cognitive function. Therefore, this study aims to utilize Computer-aided drug design (CADD) techniques to screen and optimize potential therapeutic agents targeting A. Through literature review and UniProt, we identified the active sites of A and constructed a three-dimensional structural model using AlphaFold. We employed Molecular docking technology to virtually screen a compound library for candidate molecules that may bind to A. The selected candidates were then subjected to Molecular dynamics simulation to verify their stability, and their molecular structures were further optimized using Pharmacophore modeling. Our research results indicate the successful screening of a series of candidate compounds with high affinity and selectivity. These compounds can form stable complexes with the active sites of A, thereby inhibiting its aggregation and deposition. Current structural determination methods for A have certain limitations. Techniques such as cryo-electron microscopy (cryo-EM) and scanning electron microscopy (SEM) can observe the morphology of A fibrils but typically do not provide atomic-level structural information. Additionally, A proteins tend to form non-specific aggregates in vitro, presenting challenges in preparing samples suitable for structural analysis. The innovation of this study lies in the combination of various computer-assisted technologies, offering new perspectives and methods for the drug treatment of AD and laying the groundwork for the development of novel therapeutic agents targeting A.
Innovative applications of oligopeptides in drug delivery systems: Strategies, progress and challenges
Authors: Jiang Aozhong
Published: November 2024

Abstract. Targeted drug delivery systems play an important role in new drug development. Oligopeptides, as an excellent drug delivery medium, have great biocompatibility, targeting ability, and functionalized modifications. Therefore, oligopeptides have shown great potential for application in diverse pathological conditions such as cancer, inflammatory diseases, and cardiovascular diseases, and have begun to be used in clinical therapy. This review provides a comprehensive overview of the development and applications of oligopeptide drug delivery systems and analyzes the excellent properties of oligopeptides as well as the challenges. Further research is needed to optimize the biocompatibility of oligopeptides, improve their targeting and solubility, as well as explore other new application areas.
Comments on prescriptions of big data from outpatient and emergency services using R
Authors: Zhu Xinyi
Published: November 2024

Abstract. To explore the high-frequency influencing factors of unqualified prescriptions, and promote rational drug use, the author evaluated on prescriptions of 245,352 from outpatient and emergency services using R in a large 3A hospital in 2023. Among the 245,352 prescriptions, 1,327 were evaluated as unreasonable, with a percentage of 0.54%. There were 1,368 issues related to irrational drug usage. Among the irrational prescriptions identified, the most prominent issues were inappropriate indications (59.16%) and incomplete writing in clinical diagnosis (17.78%). The departments with relatively high rates included head and neck surgery (5.94%), general medicine (3.33%), and convenient outpatient service (2.02%). The top five drugs in irrational prescriptions were Atorvastatin calcium tablets, Aspirin enteric-coated tablets, Calcium carbonate D3 tablets, Rabeprazole sodium enteric-coated tablets, and Metformin tablets, which were commonly used in chronic diseases. There was no significant correlation between the irrational rate and the professional title of the prescribing doctor. Overall, the quality of prescriptions in the hospital was satisfied, but there were still cases of irrational drug use. Hospitals should strengthen prescription review and rational drug use management to ensure the safety and effectiveness of patient medication.
Transitional B cells in PBMCs and its pathogenesis in SLE using sc-RNA sequencing data
Authors: Tu Yikai
Published: November 2024

Abstract. Systemic lupus erythematosus (SLE) is a autoimmune disorders with multisystems and organs such as kidney, lung and heart et. al. The abnormal functions of B cells induced the pathogenesis and pathological progression of this disease. The therapeutic strategies targeting B cells have been used clinically to treat SLE, achieved encouraging result. However, some patients have side effects such as infection caused by excessive humoral immune suppression. Sc-RNA sequencing technology can sequence the overall RNA in the level of single cell, aiming to classify cells, thus achieving to target B cell subgroups precisely. This article utilized transcriptome sequencing data of single cell from PBMCs in the GEO database, and subsequently analysed for dimensionality reduction clustering and data screening using R packages. Ultimately, the author discovered highly variable genes and related pathways of SLE samples transitional B cells, providing possible directions to explore SLE related treatment candidates in future.
Supramolecular nanomedicine targeted therapy for tumor treatment
Authors: Peng Jiayi , Ren Yihan
Published: November 2024

Abstract. In recent years, the incidence of multiple myeloma (MM) has been increasing significantly and showing a trend of younger age. With the advent of new therapies, the median overall survival of patients with MM has improved, but some still relapse early or even pass away. Meanwhile, chemotherapy drugs such as Bortezomib (BTZ) used in patients bring great pain to them because of its non-targeting. Based on this, this paper explores a supramolecular nanomedicine with targeted therapeutic effect on tumors and evaluates the potential of this drug to form new supramolecular nanomedicine. The drug is a combination of BTZ, the natural polyphenol Caffeic Acid (CA), and iron ion (Fe3+), a supramolecular design that brings many advantages to cancer treatment systems, including efficient drug loading, excellent biodegradability and bio-compatibility. Studies have shown that this supramolecular nanomedicine can effectively reduce the killing effect of chemotherapy BTZ on normal cells. This kind of supramolecular nanomedicine provides a new idea for the construction of tumor targeting drugs and is also hopeful to be applied to more chemotherapy drugs.
Cell type specific drug repurposing for breast cancer by integrating single-cell RNA sequencing and molecular docking simulation
Authors: Zhao Jianliang
Published: November 2024

Abstract. Breast cancer is the most frequently diagnosed cancer and the second leading cause of cancer-related deaths among women. Despite the widespread use of chemotherapy and radiotherapy, there is an urgent need for novel treatments. This study focuses on drug repurposing for breast cancer using single-cell RNA sequencing (scRNA-seq) data. By analyzing differentially expressed genes across various breast cancer cell types, we identified potential protein targets. We then used Drug2cell to generate top cancer-related drug candidates, followed by molecular featurization of proteins and drugs. Drug-target interactions were analyzed through molecular docking, and the top drug candidates for each cell type were ranked. Our data analysis annotated ten cell types from breast cancer scRNA-seq data. Using the top ten differentially expressed genes, we identified over a hundred protein targets and conducted molecular docking analysis. Fourteen drugs, including doxorubicin and everolimus, were repurposed with supporting clinical evidence for their effectiveness in breast cancer treatment. Overall, this drug-repurposing strategy, combined with scRNA-seq data, identified several cell-type-specific drugs, enhancing therapeutic target discovery and improving treatment success rates for breast cancer.
Treatment of type 2 diabetes with Kombucha tea
Authors: Gu Yubo
Published: November 2024

Abstract. The number of people with type 2 diabetes is gradually increasing worldwide, which has serious harm to human body functions. The high cost of modern drugs and safety issues have prompted people to explore the treatment and help of diet therapy for diabetes. Kombucha, as a bio-fermented beverage rich in many nutrients and antioxidants, is favored by many experimenters for its potential ability to help diabetics. Many studies on Kombucha for humans have shown that it has benefits for the human body, such as lowering blood lipids, lowering blood sugar, adjusting the immune system, and helping to promote intestinal health. Therefore, this research investigates the relevant active ingredients in Kombucha, so as to further screen and analyze the active ingredients that are beneficial to diabetics. This research aims to discuss the existing Kombucha for helping type 2 diabetes and related experiments. The existing related studies include in vitro experiments, mouse experiments, and human experiments. The review of these articles forms a complete verification channel to study and summarize the relevant mechanisms and results of Kombucha in helping diabetics.
Research on the functional properties and extraction methods of dietary fiber
Authors: Tian Wang
Published: November 2024

Abstract. Dietary fiber is a form of polysaccharide that does not yield energy and cannot be fully broken down and absorbed by the digestive enzymes in humans. Furthermore, the human body is unable to produce it; instead, food produced from plants is the only source of it. There are specific species of gut microbiota that ferment dietary fiber, producing short-chain fatty acids, monosaccharides, and gases as byproducts. Dietary fiber has both physicochemical (solubility, viscosity, absorption, water holding capacity, and oil holding capacity) and functional properties (glucose adsorption, cholesterol adsorption, and nitrite ion adsorption ). Dietary fiber can be extracted from plant using a variety of techniques, including chemical, mechanical, and enzymatic methods; however, these techniques have significant shortcomings, such as narrow extraction zones and poor extraction quality. Through the course of the last few centuries, the amount of dietary fiber has significantly decreased, which has led to unhealthy human conditions like obesity, cancer, type 2 diabetes, and constipation. Nowadays, these Dietary fibers, therefore, are given great attention because of their physicochemical and functional properties which are vital for human health. These products from plant resources and fruits can be further used for food manufacturing and processing.
Evaluation of traditional lung cancerdetection modalities and research and application of biomarkers in the early detection of lung cancer
Authors: Ou Yue
Published: November 2024

Abstract. At present, the cancer that kills people the fastest worldwide is lung cancer, and many lung cancer patients are found or detected at the late stage of lung cancer, which is very bad for the prognosis of the disease, and makes the mortality rate of the patients increase greatly. Therefore, the development of techniques for the early diagnosis and detection of lung cancer is imperative. At the moment, lung cancer can be detected early due to biomarkers. This review primarily outlines the many kinds of biomarkers and the conventional techniques for detecting and diagnosing lung cancer. In addition, bodily fluids potential application as biomarker carriers in the detecting of cancer development and progression is mentioned in this review, the feasibility of non-invasive cancer diagnostic methods is analyzed, and the current status of the development of such diagnostic methods is summarized.
Effects of different types of music on spatial memory in mice
Authors: Lv Dan , Zhang Mingjia , Fu Binying , Zheng Jiale
Published: November 2024

Abstract. A preliminary investigation was conducted to find out whether different types of music have an effect on spatial memory in adult mice. Thirty mice were divided into six groups, each half male and half female, namely, female pop group, male pop group, female classical group, male classical group, female control group, male control group, and kept in cages and fed freely. There was a reduction in latency time in the musical group compared to the control group. There was a significant difference between the classical group and the control group (P<0.05), while there was no significant difference between the pop group and the control group (P>0.05). There was an enhancement of spatial memory in mice by classical music and no statistically significant enhancement of spatial memory in mice by popular music.
A study of external machine control pathways based on brain-computer interfaces
Authors: Zhu Minghao
Published: November 2024

Abstract. This research analyses three fundamental paradigms in brain-computer interface (BCI) systems: motor imagery (MI), sensorimotor rhythms (SMRs), and P300-based paradigms, focusing on their methodology and applications. Motor imagery-based brain-computer interface (MI-BCI) entails mentally practicing motor activities while adjusting electroencephalography (EEG) patterns and utilising multimodal stimulation to enhance the accuracy of classification. SMR-BCI employs precise EEG band oscillations to operate prosthetics and virtual environments. Sensory threshold neuromuscular electrical stimulation is used to improve performance. The P300 paradigm utilizes event-related potentials to control devices, and includes advancements such as the omitted elicited paradigm to enhance efficiency. In addition, the study examines control strategies for BCI systems, such as PID, MPC, and shared control approaches. By utilizing MATLAB as a tool, one may ascertain the distinction between different control strategies, highlighting their respective contributions to improving system responsiveness and stability.
Effect of M6A methylation on T cell homeostasis
Authors: Sun Zixiang
Published: November 2024

Abstract. The m6A methylation modification is a prevalent form of RNA modification in organisms, exerting its influence on gene expression. In recent years, there has been a gradual elucidation of the relationship between the physiological functions of m6A methylation modification and immune regulation, obesity, as well as malignant diseases such as tumors. Consequently, the study of m6A methylation modification has emerged as a focal point in current molecular biology research. This research focuses on the interaction between immune system homeostasis and m6A methylation alteration and the human immune system. It also describes the significant effects of three crucial regulatory proteins required for m6A methylation modification on the growth and differentiation of immune cells (T cells). This research provides a novel direction for future studies in immunology and disease pathology. However, there are still some research difficulties, for instance, a number of methyltransferases, demethylases, and recognition proteins control the alteration of m6A methylation, and the interaction and regulatory network among these proteins are not clear, so future research can focus on this direction.
New biological dressings in diabetic wound healing: Dual effects of anti-infection and immune regulation
Authors: Gao Yanshen
Published: November 2024

Abstract. As a global epidemic, one of the complications of diabetes is chronic difficult heal wounds, especially infectious wounds, which pose a major threat to the quality of life and prognosis of patients. Traditional dressing materials (gauze, film, foam) often have limited effect, and can easily lead to prolonged treatment cycles and antibiotic resistance. In recent years, as an innovative wound management strategy, biological dressings (hydrogels, fiber scaffolds, microneedle patches) have attracted extensive attention due to their antibacterial effect, inhibition of infection, regulation of the body's immune system, promotion of tissue repair, and good biocompatibility. Here, we discuss the impact of diabetes on the body's immune system, tissue cells, and metabolic processes. In addition, we reviewed the specific mechanisms of different biological dressings in the treatment of diabeti-infected wounds. Finally, we discuss current challenges and future research directions.
Microorganisms and microbial metabolites: The next frontier in skincare products
Authors: Lyu Yiang
Published: November 2024

Abstract. Microorganisms and microbial metabolites are important resources for skincare product ingredients. The development of synthetic biology has brought more opportunities for the application of microorganisms and their metabolites in skincare products. With increasing consumer interest in natural and probiotic skincare, market acceptance of microbial metabolites is also gradually improving. However, this trend faces challenges such as regulatory issues, technical difficulties, and cost constraints. This paper explores the application prospects of microorganisms and their metabolites in skincare products, focusing on a review of several major microorganisms and their metabolites, including Bifidobacterium, Lactobacillus, and Saccharomyces cerevisiae, and their mechanisms of action in skincare. Additionally, it analyzes the potential application value of other microorganisms in skincare, such as Cutibacterium acnes and Streptococcus thermophilus, which have also been found to have positive effects on skin health. Finally, the review identifies the current opportunities and challenges faced by microorganisms and their metabolites in the skincare field, providing direction for future research.