bluuebunny/crossref_metadata_2025 huggingface dataset:
The Changing Role of Chinese English-as-Foreign-Language Teachers in the Context of Curriculum Reform: Teachers’ Understanding of Their New Role
Authors: Lei Man , Medwell Jane
Published: July 2022

The New Curriculum Standards for teaching English introduced major changes in the culture of teaching and learning English in the Peoples Republic of China (PRC). Changes have been linked to changing goals for English instruction and a revision of Confucian values in schooling. In this article, we argue that this English curriculum proposes a new role, with new demands, for English-as-foreign-language (EFL) teachers in the PRC. In order to implement the curriculum reform successfully, teachers involved in the reform are required to have a shared understanding of its nature, purposes and scope. However, little is known about to what extent EFL teachers understand and engage with their new roles. This study examines teachers’ understandings of the new curriculum and of the new, demanding role of teachers implied by the curriculum. This is a mixed methods study involving an analysis of the curriculum document, a survey (n = 227) of EFL teachers and semi-structured interviews with a sample of teachers in the cohort (n = 18). The findings suggest that many teachers know the content of the curriculum document, but expressed uncertainty about the implications of changes, uncertainty about what a shift to student-centered teaching and learning means and confusion about new professional development demands. The findings of this study have wider implications for EFL teachers, teacher educators, researchers and policy makers in the PRC and similar national contexts. This article highlights that, from an international perspective, introducing new ideas and practices should consider teachers’ existing understanding and experiences of the curriculum as well as the way in which they understand the purposes of the changes, and should promote a shared understanding of policy intentions.
Scientific Thinking About Legal Truth
Authors: Rosenzweig Gal
Published: July 2022

In the criminal process, the fact finders assess the validity of impressions reported by witnesses based on their perceptions and determine what has happened in reality. However, these impressions are not subject to any external validity check. The Innocence Project revealed the failure of this subjective method and showed how it can lead to innocent convictions. The legal literature has examined ways to manage the risk of mistakes, but these ways are inconsistent with the scientific understanding of the need for external validity measurements, suggesting the need for new ways of thinking about the legal search for truth and justice.
I’ll Do It – After One More Scroll: The Effects of Boredom Proneness, Self-Control, and Impulsivity on Online Procrastination
Authors: Sümer Cansu , Büttner Oliver B.
Published: July 2022

Procrastination is a common phenomenon. With the increasing ubiquity of new media, research has started to investigate the ways in which these technologies are used as alternatives to task engagement. This paper extends the literature by examining procrastinatory uses of social media, instant messaging, and online shopping with respect to boredom proneness, self-control, and impulsivity among German and Turkish samples. Regression analyses revealed that boredom proneness, self-control, and the perseverance facet of impulsivity are especially significant predictors of online procrastination in both samples. The results between the two studies differ in terms of impulsivity. The findings of this paper highlight the thus far understudied role of boredom proneness and various aspects of impulsivity in online procrastination, and demonstrate that social media procrastination, instant messaging procrastination, and shopping procrastination tendencies likely have distinct underlying mechanisms.
The Impact of Enhancing Phone Activeness on the Negative Effect Induced by the Presence of a Cell Phone
Authors: Liu Wenjuan , Dempo Akihiko , Shinohara Kazumitsu
Published: July 2022

In the information-driven workplace, cell phones have gradually become irreplaceable. Although the use of work-related cell phones can bring convenience, recent research has demonstrated that the presence of a cell phone can impair cognitive task performance by reducing available attentional resources and suggested that the effect of the phone’s presence can be influenced by phone-related factors. This study focused on the relationship between this effect and phone activeness and conducted two experiments to investigate whether increasing phone activeness is associated with a stronger effect from the phone’s presence by using a dual-task paradigm (primary: letter recognition task, secondary: luminance-change detection task). Phone activeness was manipulated by two potential factors: the phone’s power state (control, powered-off, powered-on) and physical contact state (the phone was placed on the desk or held in the hand). The results showed that secondary task performance decreased with the phone’s presence, regardless of its power state and contact state. This indicated that the presence of the phone only affects the available attentional resources devoted to the peripheral visual field where the secondary task stimuli occurred; however, the effect of the phone’s presence was not moderated by phone activeness. The current findings provided several extended understandings related to the negative effects caused by the presence of the cell phone and their underlying mechanisms.
Recalled Childhood Gender-Related Play Behaviour and Current Gender-Related Occupational Interests in University Students: Examining the Mediating Roles of Gender Compatibility, Goal Endorsement, and Occupational Stereotype Flexibility
Authors: Kung Karson T. F.
Published: July 2022

Substantial average gender differences in childhood play behaviour and occupational interests have been well-documented. Recent research shows that childhood gender-related play behaviour longitudinally predicts gender-related occupational interests in adolescence (Kung, 2021). The first aim of the present study was to extend this recent finding by examining whether university students’ recalled childhood gender-related play behaviour predicts their current gender-related occupational interests. The second aim of the present study was to investigate whether gender-related socio-cognitive processes mediate the relation between childhood play behaviour and subsequent occupational interests. University students (260 men, 542 women) completed scales assessing recalled childhood gender-related play behaviour, gender-related occupational interests, gender typicality, gender contentedness, agentic goal endorsement, communal goal endorsement, and gender-related occupational stereotype flexibility. In the present study, recalled childhood gender-related play behaviour predicted gender-related occupational interests in both men and women. In men, gender typicality and gender contentedness mediated the play-interests link. In women, gender typicality and communal goal endorsement mediated the play-interests link. The present study provides further evidence that childhood gender-related play behaviour is related to subsequent gender-related occupational interests. Although the current study has a correlational design, one interpretation of the current findings is that childhood play may influence socio-cognitive processes, such as gender compatibility and goal endorsement, which may in turn shape occupational interests.
Developing a Smoking Cessation Intervention for People With Severe Mental Illness Treated by Flexible Assertive Community Treatment Teams in the Netherlands: A Delphi Study
Authors: Küçükaksu Müge H. , Hoekstra Trynke , Jansen Lola , Vermeulen Jentien , Adriaanse Marcel C. , van Meijel Berno
Published: July 2022

Background

There is still limited evidence on the effectiveness and implementation of smoking cessation interventions for people with severe mental illness (SMI) in Dutch outpatient psychiatric settings. The present study aimed to establish expert consensus on the core components and strategies to optimise practical implementation of a smoking cessation intervention for people treated by Flexible Assertive Community Treatment (FACT) teams in the Netherlands.

Design

A modified Delphi method was applied to reach consensus on three core components (behavioural counselling, pharmacological treatment and peer support) of the intervention. The Delphi panel comprised five experts with different professional backgrounds. We proposed a first intervention concept. The panel critically examined the evolving concept in three iterative rounds of 90 min each. Responses were recorded, transcribed verbatim and thematically analysed.

Results

Overall, results yielded that behavioural counselling should focus on preparation for smoking cessation, guidance, relapse prevention and normalisation. Pharmacological treatment consisting of nicotine replacement therapy (NRT), Varenicline or Bupropion, under supervision of a psychiatrist, was recommended. The panel agreed on integrating peer support as a regular part of the intervention, thus fostering emotional and practical support among patients. Treatment of a co-morbid cannabis use disorder needs to be integrated into the intervention if indicated. Regarding implementation, staff's motivation to support smoking cessation was considered essential. For each ambulatory team, two mental health care professionals will have a central role in delivering the intervention.

Conclusions

This study provides insight into expert consensus on the core components of a smoking cessation intervention for people with SMI. The results of this study were used for the development of a comprehensive smoking cessation program.
Development and Comparison of Predictive Models Based on Different
Types of Influencing Factors to Select the Best One for the Prediction of OSAHS Prevalence
Authors: Fan Xin , He Mu , Tong Chang , Nie Xiyi , Zhong Yun , Lu Min
Published: July 2022

Objective

This study aims to retrospectively analyze numerous related clinical data to identify three types of potential influencing factors of obstructive sleep apnea-hypopnea syndrome (OSAHS) for establishing three predictive nomograms, respectively. The best performing one was screened to guide further clinical decision-making.

Methods

Correlation, difference and univariate logistic regression analysis were used to identify the influencing factors of OSAHS. Then these factors are divided into three different types according to the characteristics of the data. Lasso regression was used to filter out three types of factors to construct three nomograms, respectively. Compare the performance of the three nomograms evaluated by C-index, ROC curve and Decision Curve Analysis to select the best one. Two queues were obtained by randomly splitting the whole queue, and similar methods are used to verify the performance of the best nomogram.

Results

In total, 8 influencing factors of OSAHS have been identified and divided into three types. Lasso regression finally determined 6, 3 and 4 factors to construct mixed factors nomogram (MFN), baseline factors nomogram (BAFN) and blood factors nomogram (BLFN), respectively. MFN performed best among the three and also performed well in multiple queues.

Conclusion

Compared with BAFN and BLFN constructed by single-type factors, MFN constructed by six mixed-type factors shows better performance in predicting the risk of OSAHS.
Smoking Status and Cognitive Function in a National Sample of Older Adults
Authors: Zhang Qiaoyang , Zhang Min , Chen Yun , Zhu Shumin , Zhou Wang , Zhang Lihao , Dong Guanzhong , Cao Yin
Published: July 2022

Aims

To examine the correlation between smoking status and different domains of cognitive function in elderly Americans.

Methods

We used data from the 2011 to 2014 U.S. National Health and Nutrition Examination Survey (NHANES). Participants over 60 years with available smoking history and cognitive function data were enrolled in our analysis. The NHANES study included the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) assessment, the Animal Fluency Test (AFT), and the Digit Symbol Substitution Test (DSST) to assess cognition. Multivariate regression analyses were used to estimate the association between cigarette smoking and cognitive function.

Results

A total of 2,932 participants were enrolled in the analysis, including 372 (12.7%) current smokers, 1,115 (38%) former smokers, and 1,445 (49.3%) never smokers. Never smokers had in average 3.82 (95% CI, 2.21 to 5.43) points more than current smokers in the DSST, whereas former smokers had 3.12 (95% CI, 1.51 to 4.73) points more than current smokers. Besides, smoking was not associated with the results of the AFT or the CERAD test.

Conclusions

This study suggests that cigarette smoking is associated with processing speed among the American elderly.
Toxic Air Pollutants and Their Effect on Multiple Sclerosis: A Review Study
Authors: Mohammadi Mohammad Javad , Zarea Kourosh , Hatamzadeh Nasser , Salahshouri Arash , Sharhani Asaad
Published: July 2022

Toxic air pollutants are one of the main factors that have the effect of synergism to increase the incidence of multiple sclerosis (MS). This review aims to investigate the effects of toxic air pollutants on the occurrence of multiple sclerosis (MS). A narrative review of the literature was done from 2000 to 2022 based on various databases such as Google Scholar, Web of Science, Springer, PubMed, and Science Direct. In this study, according to the databases, three hundred and sixty articles were retrieved. Of these, 28 studies were screened after review and 14 full-text articles entered into the analysis process. Finally, 9 articles were selected in this study. According to the finding of this study, toxic air pollutants including polycyclic aromatic hydrocarbons (PAHs), heavy metals (HM), volatile organic compounds (VOCs), particulate matter (PM), and gases are the main agents that cause the development and spread of chronic diseases such as respiratory and cardiovascular diseases, chronic obstructive pulmonary disease (COPD), and multiple sclerosis. The result of this study showed that the main sources of emission of toxic air pollutants include industries, cars, power plants, and the excessive consumption of fossil fuels. In general, the inhalation of high concentration of toxic air pollutants can increase the risk of chronic diseases and multiple sclerosis.
Genotoxicity of Particles From Grinded Plastic Items in Caco-2 and HepG2 Cells
Authors: Roursgaard Martin , Hezareh Rothmann Monika , Schulte Juliane , Karadimou Ioanna , Marinelli Elena , Møller Peter
Published: July 2022

Large plastic litters degrade in the environment to micro- and nanoplastics, which may then enter the food chain and lead to human exposure by ingestion. The present study explored ways to obtain nanoplastic particles from real-life food containers. The first set of experiments gave rise to polypropylene nanoplastic suspensions with a hydrodynamic particle size range between 100 and 600 nm, whereas the same grinding process of polyethylene terephthalate (PET) produced suspensions of particles with a primary size between 100 and 300 nm. The exposure did not cause cytotoxicity measured by the lactate dehydrogenase (LDH) and water soluble tetrazolium 1 (WST-1) assays in Caco-2 and HepG2 cells. Nanoplastics of transparent PET food containers produced a modest concentration-dependent increase in DNA strand breaks, measured by the alkaline comet assay [net induction of 0.28 lesions/106 bp at the highest concentration (95% CI: 0.04; 0.51 lesions/106 base pair)]. The exposure to nanoplastics from transparent polypropylene food containers was also positively associated with DNA strand breaks [i.e., net induction of 0.10 lesions/106 base pair (95% CI: −0.04; 0.23 lesions/106 base pair)] at the highest concentration. Nanoplastics from grinding of black colored PET food containers demonstrated no effect on HepG2 and Caco-2 cells in terms of cytotoxicity, reactive oxygen species production or changes in cell cycle distribution. The net induction of DNA strand breaks was 0.43 lesions/106 bp (95% CI: 0.09; 0.78 lesions/106 bp) at the highest concentration of nanoplastics from black PET food containers. Collectively, the results indicate that exposure to nanoplastics from real-life consumer products can cause genotoxicity in cell cultures.
Care of Older Persons in Eastern Africa: A Scoping Review of Ethical Issues
Authors: Mussie Kirubel Manyazewal , Setchell Jenny , Elger Bernice Simone , Kaba Mirgissa , Memirie Solomon Tessema , Wangmo Tenzin
Published: July 2022

Introduction

The aging population is rapidly increasing globally, with 80% of the older population living in low- and middle-income countries. In Eastern African countries, there exists an incongruence between readiness–economically, structurally, politically, and culturally–to create a conducive environment for healthy aging, which implies public health as well as ethical concerns. The aim of this scoping review was to explore existing evidence addressing the various ethical issues in connection with elder care in the region of Eastern Africa.

Methods

We searched six databases (Africa-Wide Information, AgeLine, CINHAL, MEDLINE, APA PsycInfo, and SocINDEX) to identify peer-reviewed journal articles that could meet some eligibility criteria such as being a peer-reviewed journal article written in English, having been published in any year until July 2020, and focusing on ethical issues in the care of older people aged 60 years and older from Eastern Africa. We also searched for additional evidence in the references of included papers and web-based platforms. We included 24 journal articles and analyzed them using the inductive content analysis approach.

Results

The included articles represent seven (38.9%) of the 18 countries in the Eastern African region. The articles covered six ethical concerns: lack of government attention to older persons (n = 14, 58.3%), inaccessibility of health care services (n = 13, 54.2%), loneliness and isolation (n = 11, 45.8%), gender inequalities in old age (n = 9, 37.5%), mistreatment and victimization (n = 8, 33.3%), and medical errors (n = 2, 8.3%).

Conclusion

This scoping review summarized ethical issues arising in relation to providing care for older persons in the Eastern African context. In light of the rapid increase in the number of older persons in this region, it is critical for governments and responsible bodies to implement and accelerate efforts promptly to generate more evidence to inform programs and policies that improve the health and wellbeing of older persons. Further research is needed to inform global health efforts that aim at improving the lives of older persons, particularly in low- and middle-income countries.

Clinical Trial Registration

https://osf.io/sb8gw, identifier: 10.17605/OSF.IO/SB8GW.
Disparities in the Prevalence of Childhood Obesity-Related Comorbidities: A Systematic Review
Authors: Obita George , Alkhatib Ahmad
Published: July 2022

Background

Non-communicable diseases among children are serious consequences of childhood obesity. However, less is known about the disparities in childhood obesity comorbidities burden. This review describes the salient pattern of disparities in the prevalence of childhood obesity-related non-communicable diseases and relevant inequalities in both high- and low/medium-income countries.

Method

A systematic literature search was performed in MEDLINE, Embase, CINAHL, PsycInfo, Scopus, and Web of Science databases by two independent reviewers. Inclusion criteria were as follows: age 2–18 years; the prevalence or incidence of childhood obesity comorbidities reported; and studies published in English from January 2010 to date. No restrictions on the setting. The prevalence data were analyzed using range and median for subgroups based on the country's development status, gender, and geographical region.

Results

Our search identified 6,837 articles, out of which we examined 145 full-text articles and included 54 articles in the analysis. The median prevalence of childhood obesity-related hypertension was 35.6 vs. 12.7% among middle- and low-income countries compared with high-income countries; 37.7 vs. 32.9% among boys compared with girls; and 38.6, 25.3, and 20.1% in Asia, South America, and Europe, respectively. For metabolic syndrome, the median prevalence was 26.9 vs. 5.5% among middle- and low-income countries compared with high-income countries; 55.2 vs. 12.0% among boys compared with girls; and 40.3, 25.8, and 7.7% in South America, Asia, and Europe, respectively. The prevalence of childhood obesity-related non-alcoholic fatty liver disease was 47.5 vs. 23% among middle- and low-income countries compared with high-income countries; and 52.1, 39.7, and 23.0% in Asia, South America, and Europe, respectively. The median prevalence of dyslipidemia was 43.5 vs. 63% among middle- and low-income countries compared with high-income countries; 55.2 vs. 12.0% among boys compared to girls; and 73.7 and 49.2% in Australia and Europe, respectively.

Conclusion

There are disparities in the prevalence of childhood obesity-related hypertension, metabolic syndrome, and non-alcoholic fatty liver disease, with middle- and low-income countries, boys, and Asian region having higher prevalence. Implementing targeted interventions for childhood obesity comorbidities should consider socioeconomic disparities and strengthening of research surveillance methods for a better understanding of non-communicable disease burden in the pediatric population.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO, identifier: CRD42021288607.
The Fourth Industrial Revolution – Smart Technology, Artificial Intelligence, Robotics and Algorithms: Industrial Psychologists in Future Workplaces
Authors: Oosthuizen Rudolf M.
Published: July 2022

In the Fourth Industrial Revolution (4IR), STARA (smart technology, artificial intelligence, robotics, and algorithms) is predicted to replace a third of the jobs that exist today. Almost twice as many current work tasks will be handled by robots. It is forecast that by 2025, 85 million jobs may be displaced by a shift in the division of labor between humans and machines, while 97 million new roles may emerge that are more adapted to the new division of labor between humans, machines and algorithms. Industrial psychologists are playing an increasingly important role in the workplace due to these trends from a strategic intelligence perspective. The objective of this article is to present a critical review of industrial psychologists in future workplaces in the context of the 4IR - STARA. A competence model is posed for industrial psychologists to perform a strategic intelligence role in organizations in the 4IR.
Impact of Training Set Size on the Ability of Deep Neural Networks to Deal with Omission Noise
Authors: Gütter Jonas , Kruspe Anna , Zhu Xiao Xiang , Niebling Julia
Published: July 2022

Deep Learning usually requires large amounts of labeled training data. In remote sensing, deep learning is often applied for land cover and land use classification as well as street network and building segmentation. In case of the latter, a common way of obtaining training labels is to leverage crowdsourced datasets which can provide numerous types of spatial information on a global scale. However, labels from crowdsourced datasets are often limited in the sense that they potentially contain high levels of noise. Understanding how such noisy labels impede the predictive performance of Deep Neural Networks (DNNs) is crucial for evaluating if crowdsourced data can be an answer to the need for large training sets by DNNs. One way towards this understanding is to identify the factors which affect the relationship between label noise and predictive performance of a model. The size of the training set could be one of these factors since it is well known for being able to greatly influence a model’s predictive performance. In this work we pick the size of the training set and study its influence on the robustness of a model against a common type of label noise known as omission noise. To this end, we utilize a dataset of aerial images for building segmentation and create several versions of the training labels by introducing different amounts of omission noise. We then train a state-of-the-art model on subsets of varying size of those versions. Our results show that the training set size does play a role in affecting the robustness of our model against label noise: A large training set improves the robustness of our model against omission noise.
Who Gardens and How in Urban USA: Informing Social Equity in Urban Agriculture Action Plans
Authors: Das Kirti , Ramaswami Anu
Published: July 2022

Urban agriculture, is increasingly incorporated into food system policies to address social equity. However, assessing its effectiveness requires primary data on the demographics of agricultural gardeners and the type of gardening pursued, which are limited. This paper reports on a first detailed survey of 6,152 representative urbanites in three US cities, enabling a detailed demographic analysis of agricultural gardeners. We find low engagement in community vs. household agricultural gardening (~2% vs. ~27%). Indoor and outdoor household agricultural gardening was generally dominated by higher-income, White, males (24–44%). Community agricultural gardening appears more diverse; however, participation is low, hence, benefits may not scale up. Designing urban agriculture to address social equity requires gathering data on who gardens and how, for which our paper provides a first template.
Reactive Oxygen Species in the Adverse Outcome Pathway Framework: Toward Creation of Harmonized Consensus Key Events
Authors: Tanabe Shihori , O’Brien Jason , Tollefsen Knut Erik , Kim Youngjun , Chauhan Vinita , Yauk Carole , Huliganga Elizabeth , Rudel Ruthann A. , Kay Jennifer E. , Helm Jessica S. , Beaton Danielle , Filipovska Julija , Sovadinova Iva , Garcia-Reyero Natalia , Mally Angela , Poulsen Sarah Søs , Delrue Nathalie , Fritsche Ellen , Luettich Karsta , La Rocca Cinzia , Yepiskoposyan Hasmik , Klose Jördis , Danielsen Pernille Høgh , Esterhuizen Maranda , Jacobsen Nicklas Raun , Vogel Ulla , Gant Timothy W. , Choi Ian , FitzGerald Rex
Published: July 2022

Reactive oxygen species (ROS) and reactive nitrogen species (RNS) are formed as a result of natural cellular processes, intracellular signaling, or as adverse responses associated with diseases or exposure to oxidizing chemical and non-chemical stressors. The action of ROS and RNS, collectively referred to as reactive oxygen and nitrogen species (RONS), has recently become highly relevant in a number of adverse outcome pathways (AOPs) that capture, organize, evaluate and portray causal relationships pertinent to adversity or disease progression. RONS can potentially act as a key event (KE) in the cascade of responses leading to an adverse outcome (AO) within such AOPs, but are also known to modulate responses of events along the AOP continuum without being an AOP event itself. A substantial discussion has therefore been undertaken in a series of workshops named “Mystery or ROS” to elucidate the role of RONS in disease and adverse effects associated with exposure to stressors such as nanoparticles, chemical, and ionizing and non-ionizing radiation. This review introduces the background for RONS production, reflects on the direct and indirect effects of RONS, addresses the diversity of terminology used in different fields of research, and provides guidance for developing a harmonized approach for defining a common event terminology within the AOP developer community.
The Power of Advocacy: Advancing Vision for Everyone to Meet the Sustainable Development Goals
Authors: Lazuka-Nicoulaud Eva , Naidoo Kovin , Gross Kristan , Marcano Williams Judith , Kirsten-Coleman Andrea
Published: July 2022

Advocacy is instrumental to achieving significant policy change for vision. Global advocacy efforts over the past decades enabled recognition of vision as a major public health, human rights, and development issue. The United Nations General Assembly adopted its first-ever Resolution on vision: “Vision for Everyone—Accelerating Action to Achieve the Sustainable Development Goals (SDGs)” on 23 July 2021. The Resolution sets the target and commits the international community to improve vision for the 1.1 billion people living with preventable vision impairment by 2030. To fulfill their commitments, governments and international institutions must act now. Advocacy remains instrumental to mobilize funding and empower governments and stakeholders to include eye health in their implementation agenda. In this paper, we discuss the pivotal role advocacy plays in advancing vision for everyone now and in the post-COVID-19 era. We explore the link between improved eye health and the advancement of SDGs and define the framework and key pillars of advocacy to scaling-up success by 2030.
Ustrój lokalnego samorządu terytorialnego w Republice Słowackiej. Ile musi się zmienić, aby wszystko pozostało tak samo?
Authors: Pytlik Bogusław
Published: July 2022

The article presents the key constitutional characteristics of Slovakian local government units, as well as actions that were taken to reinstate the local government and introduce further changes, whose expected result would be the structural and functional optimization of local government units, most importantly the Slovakian communes. The article is mainly concerned with the ongoing debate over the condition of Slovakian communes and the projects to refine them. The analysis of the resolutions proposed by the central and local government leads to the belief that the consolidation process will not be over soon, and the inefficiency is meant to last. The local development and public wellbeing are being dwarfed by the interests of political parties and other lobby groups in the form of major national self-government organizations.
Funkcjonowanie instytucji publicznych w percepcji sadowników z regionu sandomierskiego w okresie pandemii COVID-19
Authors: Karaczun Zbigniew , Swacha Piotr , Herudziński Tomasz
Published: July 2022

The COVID-19 pandemic has affected every aspect of social life and the economy. The aim of the article is to present the opinion of growers from the Sandomierz region on the impact of the COVID-19 pandemic on fruit production, as well as to determine their sense of agency (impact on local and national matters) and to indicate their point of view about public institutions and non-governmental organizations’ support for Polish agriculture. The quantitative and qualitative study was conducted during the third wave of the COVID-19 pandemic. The obtained results indicate that the impact of the pandemic on the fruit growers was not significant. Nevertheless, fruit producers consider the support of public institutions as insufficient, and at the same time formulate high expectations towards them.
Mission Architecture to Characterize Habitability of Venus Cloud Layers via an Aerial Platform
Authors: Agrawal Rachana , Buchanan Weston , Arora Archit , Girija Athul , De Jong Maxim , Seager Sara , Petkowski Janusz , Saikia Sarag , Carr Christopher , Grinspoon David , Longuski James ,   on behalf of Venus Life Finder Mission Team
Published: July 2022

Venus is known for its extreme surface temperature and its sulfuric acid clouds. But the cloud layers on Venus have similar temperature and pressure conditions to those on the surface of Earth and are conjectured to be a possible habitat for microscopic life forms. We propose a mission concept to explore the clouds of Venus for up to 30 days to evaluate habitability and search for signs of life. The baseline mission targets a 2026 launch opportunity. A super-pressure variable float altitude balloon aerobot cycles between the altitudes of 48 and 60 km, i.e., primarily traversing the lower, middle, and part of the upper cloud layers. The instrument suite is carried by a gondola design derived from the Pioneer Venus Large Probe pressure vessel. The aerobot transmits data via an orbiter relay combined with a direct-to-Earth link. The orbiter is captured into a 6-h retrograde orbit with a low, roughly 170-degree, inclination. The total mass of the orbiter and entry probe is estimated to be 640 kg. An alternate concept for a constant float altitude balloon is also discussed as a lower complexity option compared to the variable float altitude version. The proposed mission would complement other planned missions and could help elucidate the limits of habitability and the role of unknown chemistry or possibly life itself in the Venus atmosphere.
Agronomic and Physicochemical Properties Facilitating the Synchronization of Grain Yield and the Overall Palatability of Japonica Rice in East China
Authors: Wei Huanhe , Ge Jialin , Zhang Xubin , Zhu Wang , Chen Yinglong , Meng Tianyao , Dai Qigen
Published: July 2022

Understanding the agronomic and physicochemical characteristics related to grain yield and grain quality is an ongoing hotspot. In 2018 and 2019, high-yielding rice with good palatability (HYGP), high-yielding rice with poor palatability (HYPP), and low-yielding rice with good palatability (LYGP) were grown in paddy fields to explore the main traits underlying the better grain yield and overall palatability of HYGP. HYGP and HYPP demonstrated a 18.1–20.7% higher grain yield (p < 0.05) than LYGP; HYGP and LYGP gave an overall palatability from 75.2 to 77.0, higher (p < 0.05) than HYPP. The higher grain yield of HYGP compared to that of LYGP resulted from a larger sink size because of the spikelets per panicle and the higher total shoot biomass weight (p < 0.05). HYGP exhibited more (p < 0.05) panicles per m2 but lower spikelets per panicle and 1000-grain weight than HYPP and maintained a similar grain yield to HYPP. Compared with HYPP and LYGP, HYGP exhibited more (p < 0.05) biomass accumulation from heading to maturity, supported by the higher leaf area index, post-heading leaf photosynthetic rate, and SPAD values. HYGP had higher (p < 0.05) adenosine diphosphate glucose pyrophosphorylase and starch branching enzyme activities at the middle and late grain-filling stages than HYPP and LYGP. HYGP and LYGP had a lower (p < 0.05) chalky area, chalky degree, amylose content, setback, grain protein content, and prolamin content than HYPP, while it had a higher (p < 0.05) gel consistency, breakdown, and ratio of glutelin content to prolamin content. Our results suggested that optimized yield components, more biomass accumulation through improved leaf photosynthetic capacities, a lower amylose content with coordinated enzyme activities involved in starch synthesis, and a lower grain protein content with a better composition were the main traits facilitating the better grain yield and overall palatability of rice in east China.
Non-Linear Model of Predictive Control-Based Slip Control ABS Including Tyre Tread Thermal Dynamics
Authors: Arricale Vincenzo Maria , Genovese Andrea , Tomar Abhishek Singh , Kural Karel , Sakhnevych Aleksandr
Published: July 2022

Vehicle dynamics can be deeply affected by various tyre operating conditions, including thermodynamic and wear effects. Indeed, tyre temperature plays a fundamental role in high performance applications due to the dependencies of the cornering stiffness and potential grip in such conditions. This work is focused on the evaluation of a potentially improved control strategy’s performance when the control model is fed by instantaneously varying tyre parameters, taking into account the continuously evolving external surface temperature and the vehicle boundary conditions. To this end, a simplified tyre thermal model has been integrated into a model predictive control strategy in order to exploit the thermal dynamics’ dependents within a proposed advanced ABS control system. We evaluate its performance in terms of the resulting braking distance. In particular, a non-linear model predictive control (NMPC) based ABS controller with tyre thermal knowledge has been integrated. The chosen topic can possibly lay a foundation for future research into autonomous control where the detailing of decision-making of the controllers will reach the level of multi-physical phenomena concerning the tyre–road interaction.
Spatial and Temporal Characteristics of Extreme Dry and Wet Events in Xinjiang from 1960 to 2020 and the Analysis of Influencing Factors
Authors: Geng Mengdie , Liu Puxing , Qiao Xuemei , Wang Miao , Wang Xingdan
Published: July 2022

It is important to consider extreme climate events, reduce disaster losses, and formulate effective disaster prevention and mitigation countermeasures. Based on the daily data from 36 meteorological stations of Xinjiang from 1960 to 2020, in order to analyze the temporal–spatial variations and influencing factors of extreme dry and wet events in Xinjiang, a number of methods were used including climate trend, the Mann–Kendall test, the Fourier power spectrum, the contribution rate, partial least squares and cross-wavelet analysis. Results indicate that the annual average frequency of extreme dry/wet events has a decreasing/increasing trend, at the rate of 0.26 times/decade and 0.19 times/decade, respectively; the variation trend in extreme dry and wet events of four seasons are consistent with the annual counterpart, at the rate of −0.04 times/decade and 0.02 times/decade (spring), −0.08 times/decade and 0.05 times/decade (summer), −0.05 times/decade and 0.06 times/decade (autumn), and −0.1 times/decade and 0.08 times/decade (winter). Fe fluctuation is greatest in winter and the smallest in spring, so the transition to warm and wet is obvious in winter and spring drought is easy to occur; the variation extent of extreme dry and wet events in northern Xinjiang exceeds the counterpart in southern Xinjiang; 1986 and 1987 witnessed abrupt variation in extreme dry and wet events in Xinjiang, with indication of distinct periodic oscillations of 2.44, 2.94, and 5.69 years and 2.94 and 5.69 years, respectively; the extreme dry (wet) events are determined by meteorological factors, comprising precipitation, relative humidity and temperature, and the circulation factors constituted by Western Pacific Subtropical High-Intensity Area (East Asian Trough Intensity, Westerly Circulation and Western Pacific Subtropical High Area) and El Niño events.
Genomic Characterization of Lactiplantibacillus plantarum Strains Possessing Differential Antiviral Immunomodulatory Activities
Authors: Albarracin Leonardo , Raya Tonetti Fernanda , Fukuyama Kohtaro , Suda Yoshihito , Zhou Binghui , Baillo Ayelén A. , Fadda Silvina , Saavedra Lucila , Kurata Shoichiro , Hebert Elvira M. , Kitazawa Haruki , Villena Julio
Published: July 2022

Lactiplantibacillus plantarum strains are used in the food industry for their probiotic properties. Some of these bacteria have immunomodulatory effects on the host and are able to improve resistance against different pathogens, including viruses. However, to date, the bacterial genes involved in the immunomodulatory effect are not known. In this work, the complete genomes of L. plantarum MPL16, CRL1506, CRL681 and TL2766 were used to perform comparative genomics with the aim of identifying the genes involved in their differential immunomodulatory effects. L. plantarum WCFS1, a strain with proven probiotic activity, was also used for comparisons. The analysis of the genes involved in the metabolic pathways of the five strains did not reveal differences in the metabolism of amino acids, lipids, nucleotides, cofactors and vitamins, nor in the genes associated with energy metabolism or the biosynthesis of lipoproteins and teichoic acids. However, differences were found between the five strains when considering carbohydrate metabolism pathways, particularly in the presence/absence of glycosylhydrolases and glycosyltransferases. In addition, a great variability was detected in the predicted surface proteins of each L. plantarum strain. These results suggest that the surface molecules expressed in the different strains of L. plantarum could be involved in their differential ability to modulate the innate antiviral immune response.
Deficiency in FTSJ1 Affects Neuronal Plasticity in the Hippocampal Formation of Mice
Authors: von Bohlen und Halbach Viola , Venz Simone , Nwakor Simon , Hentschker Christian , Hammer Elke , Junker Heike , Kuss Andreas W. , von Bohlen und Halbach Oliver , Jensen Lars R.
Published: July 2022

The role of the tRNA methyltransferase FTSJ1 in the brain is largely unknown. We analyzed whether FTSJ1-deficient mice (KO) displayed altered neuronal plasticity. We explored open field behavior (10 KO mice (aged 22–25 weeks)) and 11 age-matched control littermates (WT) and examined mean layer thickness (7 KO; 6 WT) and dendritic spines (5 KO; 5 WT) in the hippocampal area CA1 and the dentate gyrus. Furthermore, long-term potentiation (LTP) within area CA1 was investigated (5 KO; 5 WT), and mass spectrometry (MS) using CA1 tissue (2 each) was performed. Compared to controls, KO mice showed a significant reduction in the mean thickness of apical CA1 layers. Dendritic spine densities were also altered in KO mice. Stable LTP could be induced in the CA1 area of KO mice and remained stable at for at least 1 h, although at a lower level as compared to WTs, while MS data indicated differential abundance of several proteins, which play a role in neuronal plasticity. FTSJ1 has an impact on neuronal plasticity in the murine hippocampal area CA1 at the morphological and physiological levels, which, in conjunction with comparable changes in other cortical areas, might accumulate in disturbed learning and memory functions.
Dynamic Co-Evolution of Cancer Cells and Cancer-Associated Fibroblasts: Role in Right- and Left-Sided Colon Cancer Progression and Its Clinical Relevance
Authors: Ahmad Zawawi Sahira Syamimi , Musa Marahaini
Published: July 2022

Cancer is a result of a dynamic evolutionary process. It is composed of cancer cells and the tumour microenvironment (TME). One of the major cellular constituents of TME, cancer-associated fibroblasts (CAFs) are known to interact with cancer cells and promote colorectal carcinogenesis. The accumulation of these activated fibroblasts is linked to poor diagnosis in colorectal cancer (CRC) patients and recurrence of the disease. However, the interplay between cancer cells and CAFs is yet to be described, especially in relation to the sidedness of colorectal carcinogenesis. CRC, which is the third most commonly diagnosed cancer globally, can be classified according to the anatomical region from which they originate: left-sided (LCRC) and right-sided CRC (RCR). Both cancers differ in many aspects, including in histology, evolution, and molecular signatures. Despite occurring at lower frequency, RCRC is often associated with worse diagnosis compared to LCRC. The differences in molecular profiles between RCRC and LCRC also influence the mode of treatment that can be used to specifically target these cancer entities. A better understanding of the cancer cell–CAF interplay and its association with RCRC and LRCR progression will provide better insight into potential translational aspects of targeted treatment for CRC.
Chronic Low Dose Morphine Does Not Alter Two In Vitro BBB Models
Authors: Marino Jamie , Maubert Monique E. , Lawrence Jill M. , Wigdahl Brian , Nonnemacher Michael R.
Published: July 2022

The blood–brain barrier (BBB) mediates cellular and molecular passage between the central nervous system (CNS) and peripheral circulation. Compromised BBB integrity has been linked to neurocognitive deficits in multiple diseases and various infections, including those associated with HIV-1 infection. Understanding the impact of exposure to pharmaceuticals, such as those utilized for pain management by patients suffering from CNS disease, on BBB regulation and function is clinically important. In this study, we modelled two different BBB systems; a primary human co-culture and a cell line monoculture. These systems were both exposed to three daily repeat doses of morphine and examined for alterations to BBB integrity via permeability, PBMC transmigration, and chemokine gradient changes. We did not find any significant changes to either BBB system with repeat morphine dosing, suggesting that repeat morphine exposure may not play a significant role in BBB changes.
Primary and Acquired Resistance against Immune Check Inhibitors in Non-Small Cell Lung Cancer
Authors: Sun Qinying , Wei Xiangzhen , Wang Zhonglin , Zhu Yan , Zhao Weiying , Dong Yuchao
Published: July 2022

Immune checkpoint inhibitors have emerged as the treatment landscape of advanced non-small cell lung cancer (NSCLC) in recent years. However, approximately 80% of NSCLC patients do not benefit from ICIs due to primary resistance (no initial response) or acquired resistance (tumor relapse after an initial response). In this review, we highlight the mechanisms of primary and secondary resistance. Furthermore, we provide a future direction of the potential predictive biomarkers and the tumor microenvironmental landscape and suggest treatment strategies to overcome these mechanisms.
Immunohistochemical Detection of the Presence of Vitamin D Receptor in Childhood Solid Tumors
Authors: Juhász Orsolya , Jákob Noémi , Rajnai Hajnalka , Imrei Marcell , Garami Miklós
Published: July 2022

Background: Our previous work has shown a correlation between lower vitamin D levels in children with cancer and adverse prognosis. It suggests that supplying vitamin D is reasonable. VDR expression in childhood solid tumors has been linked to tumor characteristics and patient survival in only a few studies. Methods: For this study, 177 children with solid tumors were selected whose biopsies and tumor tissue formalin-fixed, paraffin-embedded tissue blocks were available for immunohistochemical analysis at Semmelweis University, Budapest (Hungary). Results: We found that non-significant VDR expression was associated with a significantly less favorable prognosis (p = 0.0061) in the examined childhood solid tumors. There was a clinically significant association; non-significant VDR expression had more than 14-fold odds of an unfavorable prognosis (OR = 14.74). The rate of VDR expression differed significantly between tumor types (p < 0.0001). Conclusion: In conclusion, VDR expression measured by IHC staining is inversely associated with aggressive characteristics in different childhood cancers. The downregulation of VDR expression in more aggressive childhood cancers suggests that functional vitamin D activity may slow or block cancer progression.
Safety and Immunogenicity of Combined DNA-Polyethylenimine and Oral Bacterial Idiotypic Vaccine for Patients with B-Cell Non-Hodgkin Lymphoma: A Pilot Study
Authors: Meleshko Alexander , Piatrouskaya Nadzeya , Vashkevich Katsiaryna , Lutskovich Dzmitry , Wang Chuan , Dormeshkin Dmitri , Savelyeva Natalia , Katsin Mikalai
Published: July 2022

We report, in brief, the results of a phase I, non-randomized study of idiotypic DNA vaccination in patients with B-cell non-Hodgkin’s lymphoma (ISRCTN31090206). The DNA sequence of lymphoma-derived immunoglobulin variable regions was used as a tumor-specific antigen fused to the potato virus X coat protein. A conjugate of plasmid DNA with polyethylenimine was used for the intramuscular injections, followed by a boost with an oral live-attenuated Salmonella vaccine carrying the same plasmid. The patients with a complete or partial response to previous chemotherapy received one or two courses of vaccination, including four injections at monthly intervals. The vaccine was well tolerated, with low-grade adverse events. The T-cell immune responses were assessed by ELISpot, at last vaccine, one week and one month post-vaccination, and were detected in 11/14 (78.6%) of the patients. In cases of progression requiring chemotherapy, or the presence of a positive MRD after the first course of vaccination, the patients underwent a second course of vaccination. At the end point, 6/19 vaccinated patients had disease stabilization, while 13/19 were in complete remission. The overall survival was 100% at follow-up, of a median of 2.3 years.