bluuebunny/crossref_metadata_2025 huggingface dataset:
An Update on Molecular Diagnostics of Squamous and Salivary Gland Tumors of the Head and Neck
Authors: Hunt Jennifer L.
Published: February 2021

Context.—Molecular testing in anatomic pathology is becoming standardized and can contribute valuable diagnostic, therapeutic, and prognostic information for the clinical management of patients. In head and neck pathology, recent advances in molecular testing have provided important targets in several different diagnostic areas, with particular emerging clinical applications in squamous and salivary gland pathology. In squamous mucosal-derived lesions, human papilloma virus has emerged as an important pathogenic etiology in a subset of oropharyngeal squamous cell carcinomas. Within the category of salivary gland tumors, 3 tumors have recently been recognized that contain oncogenic translocations.

Objective.—To describe the current state of information about the molecular alterations in squamous lesions and in salivary gland tumors of the head and neck.

Data Sources.—Published literature on squamous and salivary gland tumors of the head and neck.

Conclusions.—The different approaches to identification of viral-associated tumors include assays using polymerase chain reaction, in situ hybridization, and immunohistochemistry. Most mucoepidermoid carcinomas harbor MECT1-MAML2 gene rearrangement. The MYB-NFIB translocations have recently been identified in adenoid cystic carcinomas. Finally, a newly described tumor of salivary gland, mammary analogue secretory carcinoma, harbors the ETV6-NTRK3 translocation. Although these translocations are just emerging as diagnostic targets, future roles may evolve as potential therapeutic targets.
New Kids on the Block
Authors: Karamchandani Dipti M. , Hammad Hazed , Chetty Runjan , Arnold Christina A.
Published: February 2021

Context.—

With the increasing development and use of iatrogenic agents, pathologists are encountering more novel foreign materials in retrieved gastrointestinal specimens. These colorful and unusual-appearing foreign materials can pose a diagnostic dilemma to those unaware of their morphology, especially if the relevant clinical history is lacking.

Objective.—

To discuss the histopathologic features, clinical scenarios and significance, and differential diagnosis of relatively recently described, yet quickly expanding, family of iatrogenic agents that can present as foreign materials in gastrointestinal specimens—pharmaceutical fillers (crospovidone and microcrystalline cellulose), submucosal lifting agents (Eleview and ORISE), lanthanum carbonate, hydrophilic polymers, OsmoPrep, yttrium 90 microspheres (SIR-Sphere and TheraSphere), and resins (sodium polystyrene sulfonate, sevelamer, and bile acid sequestrants).

Data Sources.—

We collate the findings of published literature, including recently published research papers, and authors' personal experiences from clinical sign-out and consult cases.

Conclusions.—

Correct identification of these iatrogenic agents is important because the presence of some novel agents can explain the histopathologic findings seen in the background specimen, and specific novel agents can serve as diagnostic clues to prompt the pathologist to consider other important and related diagnoses. Awareness of even biologically inert agents is important for accurate diagnosis and to avoid unnecessary and expensive diagnostic studies.
Performance Characteristics of Mutational Signature Analysis in Targeted Panel Sequencing
Authors: Lawrence Lauren , Kunder Christian A. , Fung Eula , Stehr Henning , Zehnder James
Published: February 2021

Context.—

Mutational signatures have been described in the literature and a few centers have implemented pipelines for clinical reporting.

Objective.—

To describe the performance of a mutational signature caller with clinical samples sequenced on a targeted next-generation sequencing panel with a small genomic footprint.

Design.—

One thousand six hundred eighty-two clinical samples were analyzed for the presence of mutational signatures using deconstructSigs on variant calls with at least 20 variant reads.

Results.—

Signature 10 (associated with POLe mutation) achieved separation of cases and controls in hypermutated samples. Signatures 4 (associated with tobacco smoking) and 7 (associated with ultraviolet radiation) as an indicator of pulmonary or cutaneous primary sites showed moderate sensitivity and high specificity at optimal cutpoints. Mutational signatures in malignancies with unknown primaries were somewhat consistent with the clinically suspected primary site, with an apparent dose-response relationship between the number of variants analyzed and the ability of mutational signature analysis to correctly suggest a primary site.

Conclusions.—

Mutational signatures represent an opportunity for orthogonal testing of primary site, which may be particularly useful in supporting cutaneous or pulmonary sites in poorly differentiated neoplasms. Tobacco smoking, ultraviolet radiation, and POLe mutational signatures are the most appropriate signatures for implementation. Even relatively small numbers of variants appear capable of supporting a clinically suspected primary.
Low levels of vitamin D were associated with coagulopathy among hospitalized coronavirus disease-19 (COVID-19) patients: A single-centered study in Indonesia
Authors: Susianti Hani , Wahono Cesarius , Rahman Perdana , Pratama Mirza , Wulanda Indah , Hartanti Khoirunisah , Dewi Elvira , Handono Kusworini
Published: February 2021

Background: This study was aimed to explore the association of vitamin D in the risk of coagulopathy in coronavirus disease-19 (COVID-19). Methods: Clinical and laboratory findings were obtained from 50 confirmed COVID-19 patients hospitalized in Saiful Anwar General Hospital, Malang, Indonesia, from September to November 2020. Thrombotic events during hospitalization were recorded, and the ISTH disseminated intravascular coagulation (DIC) score was used to classify overt DIC. Hypovitaminosis D was defined by serum vitamin D level <49.92 nmol/L. Results: Among 50 patients, 42 (84%) had hypovitaminosis D, and 6 (12%) developed thrombotic events. Vitamin D levels were lower in patients with thrombotic events (p=0.015), D-dimer >2 mg/L (p=0.006), ISTH DIC score 5 (p=0.020), admitted on ICU (p=0.002), and non-survivor groups (p=0.007). Multivariate analysis for the risk in increased D-dimer levels showed low vitamin D as the only significant risk factor with OR 1.8 (1.2-4.4), p=0.034. Low vitamin D also increased the risk for developing overt DIC with OR. 5.4 (1.0-30.2), p=0.039. Vitamin D level had negative correlations with ferritin (R=-0.316, p=0.044) and CRP (R=-0.530, p=0.000). Conclusions: In conclusion, a low level of vitamin D was found in most hospitalized COVID-19 patients and might be associated with the development of coagulopathy.
The Crisis of European Social Sciences: The Case of Money
Authors: González Guardiola Joan
Published: February 2021

Our aim in this article is to put into practice, in the field of social sciences, the principles that Husserl displayed in his book from 1936, "The crisis of European sciences and transcendental phenomenology”. In that seminal work, Husserl reflected on the mathematization of nature and produced an historical meditation on the essence of geometry. Here we will try to extend the reach of Husserlian postulates in order to deal with economics and, more specifically, with the theory of money. We think that, in certain social sciences, and in particular in those with a clear mathematical penchant like economics, the use of formalization often helps to cover an uncritical use of phenomenologically ungrounded idealizations. This fact ultimately results in a massive concealment of the true sense of some of its principal phenomenanamely, money. It is worth mentioning that this concern does not have its roots only in phenomenology, for even academic monetary theory openly acknowledges that we lack an understanding of the meaning of money which could help us clarify and prevent financial crisis and economic collapses. Crisis, in short, are not the result of a deep understanding of the concept of money; on the contrary, they highlight the fact that we don’t really know what money is. Thus, our goal here is to illustrate the possibilities offered by the phenomenological method in its application to the question of money. It is in this sense that the research taking place here can be understood as a “phenomenological critique of monetary theory”.En el presente artículo se pretende llevar a cabo una aplicación de los principios que Husserl lleva a cabo en su obra de 1936, “La crisis de las ciencias europeas y la fenomenología transcendental”, a las ciencias sociales; concretamente, al concepto de dinero. En su obra de 1936, Husserl puso el énfasis en la matematización de la naturaleza, centrándose sobre todo en la meditación histórica sobre la geometría. Pero en el caso de algunas ciencias sociales, como la economía, la utilización libre de construcciones idealizadoras fenomenológicamente infundadas, como en el caso del dinero, está teniendo como resultado un enorme encubrimiento de sentido del fenómeno monetario. Esto no es vivido tan solo desde la feno-menología: desde la propia teoría monetaria se reconoce que estamos faltos de una comprensión del sentido del dinero que nos ayude a clarificar y prevenir de manera suficiente las crisis financieras. Estas crisis no son fruto de que hayamos comprendido demasiado bien el concepto de dinero, sino de que todavía estamos faltos de una comprensión profunda del sentido del dinero. Aquí pretendemos ilustrar las posibilidades que el método fenomenológico ofrece, aplicado al caso del dinero. En este sentido, pueden considerarse las investigaciones que tienen lugar aquí como “crítica fenomenológica de la teoría monetaria”.
Qu’est-ce qu’un signe linguistique? Le revers psychologique de la théorie husserlienne des actes de signification à l’époque des "Recherches logiques"
Authors: Gyeman Maria
Published: February 2021

Dans le § 8 de la 1ère recherche logique Husserl explique qu'est-ce que c'est l'expression (Ausdruck), par opposition à un autre type de signe: l'indice (Anzeichen). Ce qu'est en jeu, c'est la spécificité de l'expression, entendue par Husserl comme une sorte de signe qui présente un caractère clair. Mais afin de determiner l'expression Husserl effectue une opération interpretée par Derrida comme un premier type de réduction: réduction du langage a une forme du soliloque. En d'autres termes, au moment où Husserl doit expliquer ce qu'est un signe linguistique, met entre parenthèses précisément la fonction symbolique des expressions.Je tiens à souligner dans cet article les raisons qui conduisent Husserl à ce surprenant geste de mettre entre parenthèses l'une des fonctions les plus essentielles des actes significatifs, la fonction comunicative de contenus intentionnels au moyen de signes dans un contexte intersubjectif. Je montrerai après ce que conduit Husserl à examiner à nouveau cette décision et à la critiquer dans les textes de 1913-1914 lors de la préparation de la deuxième édition des Recherches logiques et publiés aujourd'hui dans le volume XX/2 de Husserliana.En el § 8 de la 1ª Investigación lógica Husserl explica qué es la expresión (Ausdrück) por oposición a otro tipo de signo: el índice (Anzeichen). Lo que se halla en juego es la especificidad de la expresión, entendida por Husserl como un tipo de signo que presenta un carácter intencional. Pero, con el fin de perfilar la expresión, Husserl realiza una operación interpretada por Derrida como un primer tipo de reducción: la reducción del lenguaje a la forma del soliloquio. En otras palabras, en el momento en el que Husserl debe explicar lo que es un signo lingüístico, pone entre paréntesis precisamente la función simbólica de las expresiones.Me gustaría poner de relieve en este artículo las razones que llevan a Husserl a este sorprendente gesto de poner entre paréntesis una de las más esenciales funciones de los actos significativos, la función de comunicar contenidos intencionales a través de signos en un context intersubjetivo. Mostraré más tarde qué lleva a Husserl revisar esta decisión y criticarla en los textos de 1913-1914 cuando preparaba la segunda edición de las Investigaciones lógi-cas y hoy publicados en el volumen XX/2 de Husserliana.
Alterity and Repetition. Phenomenological Interpretation of the Divinity in the Later Heidegger
Authors: Kageyama Yohei
Published: February 2021

The purpose of this paper is phe-nomenological interpretation of the various faces of divinity in the later Heidegger and elucidation of the human comportment corresponding to this divinity. In the first chapter, I will make clear the relation between ontological difference in the sense of the later Heidegger and the primordial dimension of divinity which is called the last god (der letzte Gott) and the sacred (das Heilige). Further, the relation between such divinity and entity as a whole (das Seiende im Ganzen) will be clarified. In the second chapter, I will elucidate the place of the divinities in the manifestation of entity as a whole by considering the role of the godlikes (die Göttlichen) in the fourfold (das Geviert). When the primordial alterity of the last god should be experienced in entity as whole, which leads to the notion of the godlikes, it must confront human subject in totally asymmetrical manner. Such asymmetrical communication can be structurally made explicit by taking the concept of “discourse” in Being and Time into account. Finally, I will consider the character of human comportment called preservation (Bergung) with focusing on its relation to the later Heidegger’s conceptions of divinity. This will shed light on how human beings could properly appreciate the experience of what is beyond our understanding and nevertheless supporting our existence.El objetivo de la ponencia es llevar a cabo una interpretación fenomenológica de las diversas facetas de la divinidad en el Hei-degger tardío y elucidar el comportamiento humano respecto de esta divinidad. En el primer capítulo, se esclarece la relación entre la diferencia ontológica en el sentido que le da el segundo Heidegger y la dimensión primordial de la divinidad, llamada el último dios (der letzte Gott) y lo sagrado (das Heilige). A conti-nuación, se esclarecerá la relación entre la divinidad así concebida y lo ente en totalidad (das Seiende im Ganzen). En el segundo apar-tado, se elucidará el lugar de las divinidades en la manifestación de lo ente en totalidad considerando el papel de los divinos la Cuaternidad (das Geviert). Cuando la alteridad primordial del último dios se experimente en lo ente en totaliadd, lo cual conduce a la noción de los divinos, tiene que enfrentarse al sujeto humano de una forma totalmente asimétrica. Esta comunicación asimétrica puede explicitarse estructuralmente mediante la consideración del concepto del discurso en Ser y tiempo. Final-mente, consideraré el carácter del comportamiento humano denominado la preservación (Bergung), con especial atención a su relación con la noción de lo divino en Heidegger tardío. Esto arrojará luz sobre cómo los seres humanos podrían apreciar de manera adecuada lo que está más allá de nuestra comprensión y sin embargo, sostiene nuestra existencia.
The Identity Theory of Propositional Truth in Dorion Cairns
Authors: Embree Lester
Published: February 2021

Previously unpublished passages from the Cairns Nachlass are assembled and commented on to present the identity theory in contrast with the traditional coherence and correspondence theories, and then seven more detailed analyses of related aspects are also edited.To say that a syntactical object is true or is a fact, is to say that the act of intending it as having a perhaps indistinct structure and a perhaps obscure material content may unite in a positive synthesis of identification with an act wherein “the same” syntactical object is distinctly and clearly evident as having “the same” structure and content. The fulfilling act is eo ipso a grasping of the still grasped syntactical object as having been produced by a syntactical activity founded in original explication of the subject-matter. The realization of such a synthesis is a verification of the truth (and consistency) of the syntactical object, a verification of the “existence” of the fact (01710).Se reúnen y comentan pasajes inéditos del Nachlass de Cairns para presentar la teoría de la identidad en contraste con las tradicionales de la coherencia y la correspondencia, también se editan luego siete análisis más detallados de aspectos relacionados.Decir que un objeto sintáctico es cierto o es un hecho, es decir que el acto de mentarlo como teniendo una estructura tal vez confusa y un contenido material tal vez os-curo, puede unir en una síntesis positiva de identificación con un acto en el que "el mismo" objeto sintáctico es clara y evidentemente teniendo "la misma" estructura y contenido. El acto de cumplimiento es eo ipso un captación del objeto sintáctico todavía captado como habiendo sido producido por una actividad sintáctica fundada en explicación original de la materia. La realización de tal síntesis es una verificación de la verdad (y la consistencia) del objeto sintáctico, una verificación de la "existencia" del hecho (01710).
Remembering and Forgetting as a Function of Life
Authors: Mensch James
Published: February 2021

As Derrida observes, the ideal of a perfect memory has a spectral quality. The desire to achieve it is like the wish of Hanson, the fictional archaeologist, to go beyond the physical remains to grasp the past itself. What seduces us is the thought that remembering is like mechanical reproduction. We forget, however, that a photograph does not remember what we looked like any more than a recording remembers the sound of our voice. Only a living being can remember. Seen in this light, the ultimate problem of the ideal of a perfect memory is that it abstracts remembering from the context in which it functions. In this paper, I argue that this context is that of our embodied being-alive, with all the limitations that this implies. Such limitations impose a teleological structure on our remembering. They determine how memory functions on both an individual and a collective level.Como observa Derrida, el ideal de la memoria perfecta tiene una cualidad espectral. El deseo de conseguirlo es como el de Hanson, el arqueólogo ficticio, de querer ir más allá de los restos físicos para alcanzar el pasado mismo. Nos seduce la idea de que recordar sea como una reproducción mecánica. Olvidamos, sin embargo, que una fotografía no recuerda cómo éramos más de lo que una grabación recuerda el sonido de nuestra voz. Sólo un ser vivo puede recordar. Desde este punto de vista, el problema último del ideal de la memoria perfecta es que abstrae el recordar del contexto en el que éste realizaría su función. En este artículo argumento que dicho contexto es el de nuestro estar-vivos encarnado, con todas las limitaciones que ello implica. Estas limitaciones imponen una estructura teleológica en nuestro recordar. Determinan como funciona la memoria, tanto a nivel individual como colectivo.
Ética y testimonio. Ideas para una fenomenología integral del "Ethos"
Authors: Garrera Nicolás
Published: February 2021

El Ethos es el fenómeno de la moralidad en su sentido más amplio. El presente trabajo –de naturaleza programática– esboza la idea de una fenomenología integral del ethos capaz de pensar, evitando toda forma de reduccionismo, sus diversos niveles de sentido. Procedemos en cinco pasos: en primer lugar, sostenemos que las experiencias humanas fundamentales –en particular la experiencia ética– son del orden de la contingencia y que, en consecuencia, sus verdades no se dejan captu-rar por el análisis fenomenológico-transcendental. En segundo término, presentamos la noción de experiencia ética, a la que describimos como la experiencia del contacto traumático de la Ley en su cuádruple carácter: singular, universal, verdadero, y contingente. En tercer lugar, vía la lectura del ensayo de Derrida Violencia y metafísica. Ensayo sobre el pensamiento de Emmanuel Levinas, ponemos en cuestión la tesis de la supuesta preeminencia de la fenomenología –en tanto que idealismo transcendental– respecto del discurso ético. En cuarto término, introducimos la noción de testimonio (en sentido ético) como la modalidad narrativa, “pre-filosófica”, capaz de expresar de la manera más fiel el sentido de la experiencia ética. Por último, distinguimos cinco niveles fundamentales del ethos y, sobre esta base, señalamos algunas de las tareas específicas de una fenomenología integral del ethos.The Ethos is the phenomenon of morality in its broadest sense. Our programmatic essay sketches the idea of a comprehen-sive phenomenology of the ethos capable of thinking –non-reductively– its different layers of meaning. We proceed in five steps: first, we claim that fundamental human experiences –in particular, ethical experience– are contingent in nature and that, as a consequence, their truths cannot be grasped by a phenomenologico-transcendental analysis. Second, we describe the notion of ethical experience as a traumatic experience of contact with the Law in its quadruple character: singular, universal, true, and contingent. Third, through a reading of Derrida’s Violence and Metaphysics. An Essay on the Thought of Emmanuel Levinas, we question the alleged preeminence of phenomenology –as transcendental idealism– over ethical discourse and praxis. Fourth, we introduce the notion of (ethical) testimony as the kind of “pre-philosophical” narrative able to convey most faithfully the meaning of ethical experience. Finally, we distinguish five fundamental layers of the ethos and, on the basis of these distinctions, we identify some of the specific tasks of a comprehensive phenomenology of the ethos.
Limit and Horizons of Linguistic Expression
Authors: Zirión Quijano Antonio
Published: February 2021

In the first part, a first exploration is made on the issue of sayability and unsayability using conceptual and investigative resources taken from the phenomenological descriptions made by Husserl in Ideas I. A first and still broad result is reached, namely, that any Erlebnis (lived experience), taken in its fullness and plenitude, is ineffable, and therefore, life itself, because it is only a stream of lived experiences, as it is lived at each and every mo-ment, is unsayable, ineffable. The limit of linguistic expression referred to in the title is, thus, its impossibility to express a full Erlebnis. Then, linguistic expression is examined against the background of the plenitude of this life that it cannot express but from which and in which it emerges, and this inspection brings to light in a preliminary way the several horizons that encircle it.En la primera parte, se hace una primera exploración del tema de la decibilidad y la indecibilidad empleando recursos metodológicos y conceptuales tomados de las descripciones fenomenológicas hechas por Husserl en Ideas I. Con ello se alcanza un primer resultado todavía muy amplio, a saber, que toda vivencia (Erlebnis), tomada en su integridad y plenitud, es inefable, y por tanto, la vida misma, puesto que consiste en una corriente de vivencias, tal como es vivida en todos y cada uno de sus instantes, es precisamente inefable, indecible. El límite de la expresión lingüística a que el título se refiere es, pues, su imposibilidad para expresar una vivencia plena. Luego, se examina la expresión lingüística contra el fondo de la plenitud de la vida que no puede expresar pero de la cual y en la cual emerge, y esta inspección trae a luz de manera preliminar los diversos horizontes que la circundan.
Violence and torture against migrants and refugees attempting to reach the European Union through Western Balkans
Authors: Guarch-Rubio Marta , Byrne Steven , Manzanero Antonio L.
Published: February 2021

Introduction: This paper presents a study of traumatic experiences, including torture, among refugees and migrants at the border between Croatia and Bosnia. The number of people being forcefully displaced is increasing and militarized border enforcement efforts have made migration a dangerous endeavour. The European Union is externalizing its borders, but migrants and refugees have not ceased arriving in Western societies despite facing violence and torture both throughout their journey, and at the gates of Europe. Method: 54 participants were assessed, 51 males and 3 females, 26 were self-declared economic migrants and 28 stated that they fled due to political or religious persecution. The Iraqi version of the Harvard Trauma Questionnaire (HTQ) was adapted to collect traumatic and torture stressors experienced by the migrants/refugees during their stay in Western Bosnia, and more specifically during their detention and refoulement (push-backs) when attempting to cross the border between Bosnia-Herzegovina and Croatia. Results: 98.14% reported experiencing multiple forms of torture, 81.5% reported having their property looted, and 70.4% stated that they had been physically harmed on the mentioned border during  migratory transit. Torture experiences were associated with the migratory and confinement phases such as exposure to the rain and cold (92.6%) or lack of food, water and medical care (66.7%). Finally, 50% of participants fulfilled the criteria for post-traumatic stress disorder (PTSD) due to the cumulative effect of traumatic experiences. Differences were found only in the amount of traumatic experiences between economic migrants and refugees who fled for political or religious reasons. No differences were found in torture experiences and PTSD diagnosis. Conclusions: Violence perpetrated by security forces against migrants is crystallized at the border-zones. Migrants are held in conditions that would amount by themselves to torture. Traumatic experiences have an effect on migrants/refugees’ mental health and can trigger the development of post-traumatic stress disorder. Guaranteeing human rights for migrants/refugees throughout their journey is needed.
Comedia de Calisto y Melibea, edición crítica, introducción y notas de José Luis Canet, Valencia, Universitat de València, Publicacions de la Universitat de València, 2011
Authors: Prieto de la Iglesia Remedios , Sánchez Antonio
Published: February 2021

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La Celestina como emblema del exilio republicano en México: la versión de Álvaro Custodio
Authors: Heras González Juan Pablo
Published: February 2021

El director de escena Álvaro Custodio (1912-1992), miembro en su juventud de La Barraca de García Lorca, formó durante su exilio en México (1944-1973) una importante compañía dedicada a los clásicos del teatro español. El montaje más representativo de la compañía fue el de su particular versión de La Celestina, a la que acudió en primer lugar por identificar la heterodoxia de Fernando de Rojas con la de los republicanos españoles. El artículo analiza con detalle las motivaciones y las decisiones dramatúrgicas que conforman su versión, entre las que destacan, entre otras cosas, el perfilado de Melibea como heroína romántica y la atribución a Pleberio de rasgos propios del padre celoso de la comedia del Siglo de Oro.
Celestina: Documento bibliográfico (suplemento número 35)
Authors: Paolini Devid
Published: February 2021

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La Celestina: A Novel
Authors: Mancing Howard
Published: February 2021

En este ensayo propongo que La Celestina debe leerse como una novela. La obra es imposible de representar en el teatro: no es un drama. Tampoco es una comedia humanística ni en su forma ni en su espíritu. Que una novela puede escribirse en la forma de una serie de cartas no es controvertido, a pesar de que carece de narrador. De igual modo hay —como ha explicado Cervantes en la introducción al Coloquio de los perros— un lazo implícito narrativo entre los segmentos de diálogo. La Celestina es una obra renacentista (y no medieval) y se ha leído siempre como novela. Es, en efecto, la primera gran novela de la edad de la imprenta.
Celestina: Documento bibliográfico (suplemento número 37)
Authors: Paolini Devid
Published: February 2021

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Reading at the Threshold: The Role of Illustrations in the Reception of the Early Editions of Celestina
Authors: Montero Ana Isabel
Published: February 2021

Ya sea en su formato original de Comedia en dieciséis actos publicada por primera vez alrededor de 1499, o en su posterior encarnación en la Tragicomedia de 1501, las numerosas ediciones y traducciones que circularon durante el siglo XVI ponen de manifiesto la enorme popularidad y el profundo impacto literario de Celestina a lo largo de Europa. Se han escrito estudios incontables sobre la recepción de Celestina desde el siglo XV hasta el momento presente. Sin embargo, no se ha dicho mucho sobre la influencia de los grabados de la primera edición conocida en el éxito de la obra: ¿Cómo los interpretaron los lectores? ¿Fueron las ilustraciones tomadas en cuenta por los editores e ilustradores de las ediciones sucesivas? Este artículo explorará la importancia de los grabados en la difusión y el éxito editorial de la obra de Rojas, así como en la creación y divulgación de la saga inmortal de Celestina, reencarnada de modo incesante gracias a la imprenta.
The Concept of Imago Agens in Celestina: Text and Image
Authors: Saguar García Amaranta
Published: February 2021

En este trabajo se exploran los vínculos potenciales entre Celestina y la reinterpretación tardomedieval del concepto clásico de la imago agens. Por un lado, examina los grabados correspondientes a las muertes de los personajes principales y los compara con algunos ejemplos de imaginería religiosa de la época que admiten ser interpretados desde este punto de vista. Por otro, pone en relación las macabras descripciones verbales de estas mismas muertes con la función ejemplar y moralizante que las imagines agentes desarrollaron durante la Baja Edad Media. Por último, analiza la importancia de la violencia, tanto en la descripción textual como en la representación visual de estas muertes, para concluir que tuvo que desempeñar una función didáctico–moral.
De viva y vieja voz: Celestina por sí misma
Authors: Gómez Goyzueta Ximena
Published: February 2021

En su artículo «Hacia una lectura feminista en La Celestina», Alan Deyermond cuestiona lo siguiente: «[...] habrá que preguntarse si la representación de la hechicería/brujería de Celestina [...] por Fernando de Rojas y su predecesor anónimo se debe explicar en términos de la represión misógina». En mi opinión, la respuesta es negativa. El trabajo que propongo consiste en mostrar que la configuración de Celestina tiende principalmente hacia la caracterización de una alcahueta ficticia, más que a ser concebida desde una perspectiva misógina. A partir de esta respuesta, analizo las formas en las que Celestina es nombrada en los paratextos y por los demás personajes; con ello, me propongo identificar el retrato ficticio de la alcahueta que construyen los autores del texto salmantino. Asimismo, observo cómo la naturaleza perspectivista del diálogo celestinesco permite, a su vez, que Celestina sea capaz de autoconcebirse en la ficción como mejor le convenga, y crear, así, su propio retrato más allá de las miradas de los demás.
Raúl Álvarez Moreno, «Celestina» según su lenguaje, Madrid, Editorial Pliegos, 2015
Authors: Canet José Luis
Published: February 2021

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Celestina. La Tragicomedia del grupo Atalaya
Authors: Gastañaga Ponce de León José Luis
Published: February 2021

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El autor del primer acto de la Comedia de Calixto y Melibea: el arcipreste de Talavera, Alfonso Martínez de Toledo
Authors: Cáseda Teresa Jesús Fernando
Published: February 2021

Este estudio trata de demostrar que Alfonso Martínez de Toledo, el autor del Corbacho, es también el autor del primer acto de la Comedia de Calixto y Melibea y, probablemente, de la estructura general de los siguientes quince actos de la primera edición de la obra. Comienza la investigación con un análisis del prólogo, analiza la figura de Calixto y lo pone en relación con la biografía del autor del Corbacho, estudia la presencia de referencias al reino de Aragón en la obra y sitúa la acción en la ciudad de Barcelona, a partir del estudio de la palabra tenerías y otras referencias textuales. A partir del estudio de diversos campos semánticos, de estructuras léxicas, estilo y muestras de oralidad comunes al Corbacho y a la Comedia de Calixto y Melibea, así como de la teoría de los humores, la astrología y la presencia de la «demanda» final del Corbacho, se establecen las semejanzas entre ambas obras.
A la sombra del De amore. Dante entre Capellanus y La Celestina
Authors: Di Patre Patrizia
Published: February 2021

A través del presente estudio me propongo mostrar cómo la obra maestra del Capellanus se encuentra organizada según los modos de una característica quaestio medieval, y responde a los mismos objetivos de declaración formal y exhaustiva –en pro y contra– de una tesis finalmente llevada a su solución definitiva. La conclusión autorial aparece en el caso que nos ocupa decididamente contraria a la apología del amor profano, cuyos efectos nefastos recorren, mediante la fundamental caracterización del canto V en el Infierno dantesco, toda la veta literaria que culmina con los desafortunados amores («homicidia malave multa sequuntur», según el pronóstico establecido en el De Amore), relatados en la Tragicomedia del primer Renacimiento.
El fin del deseo y el comienzo de la unión con Dios: Conexiones entre La Celestina y la literatura mística del siglo XVI a través del psicoanálisis
Authors: Poggi Alfredo Ignacio
Published: February 2021

Este artículo conecta la obra de Fernando de Rojas con la literatura mística española del siglo XVI y reconoce en ellas una cosmovisión compartida con respecto al deseo. En ambas visiones, los actores femeninos cobran el protagonismo en la administración del deseo y la inmanencia fragmenta el orden trascendente medieval escolástico. Además, en el espacio privado es donde se negocia el deseo y tiene un efecto concreto en el cuerpo de los participantes. Finalmente, la administración del deseo es llevada hasta las últimas consecuencias: el silencio, la nada y la muerte. Pero mientras que en La Celestina, estos elementos tienen una carga negativa, los místicos lo perciben como algo positivo, el camino hacia la divinidad.
Resucitando a la alcahueta: un estudio del desafío a la pureza de sangre y la doctrina cristiana del personaje de la medianera revivida en la Segunda comedia de la Celestina de Feliciano de Silva
Authors: Nate Andrea
Published: February 2021

En este artículo argumento que la resurrección de la Celestina cuestiona la noción de la pureza de sangre, así como ciertos aspectos de la doctrina cristiana que la población conversa se veía obligada a reconocer oficialmente. Comparo la secuela de Silva con las escenas de resurrección en varias obras literarias medievales, así como las de ciertos textos de contemporáneos suyos. Concluyo que Silva invierte el motivo de la resurrección milagrosa, utilizándolo como punto de partida no sólo para continuar el argumento de La Celestina, sino también para recoger varias posibles funciones de la Comedia de Calisto y Melibea y la Tragicomedia de Calisto y Melibea. Tras analizar los grabados en la edición de Medina del Campo 1534, el lenguaje y el contexto histórico, muestro que Segunda Celestina, a través de la alcahueta resucitada, parece recoger la crítica social y la interrogación de varios paradigmas literarios, religiosos y culturales que parecen llevar a cabo la Comedia y Tragicomedia originales. Por último, propongo que la secuela, leída de cierto modo al lado de La Celestina, nos ayuda a entender la recepción de la alcahueta famosa y su vinculación con cuestiones de la marginación social.
Vela, Marta [2019]. Correspondencias entre música y palabra. Un estudio sinestésico sobre Harmonie du soir, Baudelaire/Debussy, y Le Gibet, Bertrand/Ravel
Authors: Seguí Balaguer Montiel
Published: February 2021

Recensión de libro:
Vela, Marta [2019]. Correspondencias entre música y palabra. Un estudio sinestésico sobre Harmonie du soir, Baudelaire/Debusy, y Le Gibet, Bertrand/Ravel.
Hudging, Nicole [2020]. The Gender of Photography: How Masculine and Feminine Values Shaped the History of Nineteenth-Century Photography
Authors: Onfray Stéphany
Published: February 2021

Recensión del libro:
Hudgins, Nicole [2020]. The Gender of Photography: How Masculine and Feminine Values Shaped the History of Nineteenth-Century Photography. Londres: Bloomsbury Publishing PLC.
El punto de giro de Kardashian o el final del 'selfie'
Authors: San Cornelio Gemma
Published: February 2021

Hace un tiempo que escribo sobre selfies en Instagram en el contexto del proyecto selfiestories. A propósito de la desaparición y reaparición de Kim Kardashian en la red, en este artículo me gustaría profundizar en dicho incidente desde la perspectiva de la narrativa personal, a la vez que interpretarlo como otro indicio (más) de lo que podríamos entender como el final del selfie.
Christine Wilks’ Women, Politics and Poetics
Authors: Doménech Oreto
Published: February 2021

In this paper we present a close reading of the electronic literature works Sitting Pretty (2004), IntraVenus (2005), Fitting the Pattern (2008) and Underbelly (2010) by Christine Wilks with the aim of reflecting on how the body of the “Woman” is represented in these works, through which mechanisms the gender is constructed in them and how these bodies of women are registered in a feminine and feminist genealogy. There is, without a doubt, in Wilks’s work a unitary discursive thread about gender identity that evolves and transforms as the narrative mechanisms of the author and, consequently, our reading process, change; the power of the word over the body in Sitting Pretty and the strength of the naked body in IntraVenus are the initial drawing of a particular and personal discourse about the genre that will become more complex and profound in Fitting the Pattern and Underbelly. In Fitting the Pattern we have to cut, sew and weave to know the thoughts of the daughter, the addressee of the pattern that is made. Reading, as an act of creative craftsmanship, coupled with the memory of women who rework, stitch after stitch, maternal relationships, in a textual fabric that makes the identity of a young woman and the memory of a long female genealogy. Genealogy which, on the other hand, is omnipresent in Underbelly, an immersive reading experience that introduces mining women in the 19th century England along with the thoughts of a sculptress about her process as an artist who is wondering about the possibility of being a mother. The texts that narrate Sitting Pretty, IntraVenus, Fitting the Pattern and Underbelly appear in the most diverse and heterogeneous forms, however the images in these works are representations of the body of the woman from different points of view: the physical body, the body of desire, the body covered, the inner body. These works, in addition, due to their specific and special characteristics, experience a process of poetization with peculiar rhetorical mechanisms that are configured in digital poetic narratives: orality, metaphors, alliterations, metonimies, rhythm, analogies, polysemy … Reading these four works is an interactive experience of the body, an intellectual dialogue about the meaning of the word and power, the body and the image, reading and memory, women and the creation through times and spaces and practicing, with reading, the exercise of a poetic and political view.
Abrikossoff’s Tumour of Oesophagus- An Innocent Bystander or a Silent Killer?
Authors: Senthamizhselvan Kuppusamy , Mohan Pazhanivel , Srinivas Bheemanathi Hanuman , Hamide Abdoul
Published: February 2021

Oesophageal Granular Cell Tumour (GCT) is a rare tumour arising from schwann cells of the submucosal nerve plexus. They are slow-growing generally, benign though malignant potential has been reported. They are usually found incidentally during endoscopic evaluation of dyspepsia or dysphagia. They rarely produce symptoms on their own unless the size is larger, ulceration occur on their surface or when it compresses the adjacent structure. Though they are submucosal, they are usually diagnosed by standard biopsy techniques or after an endoscopic resection. Oesophageal GCTs without muscularis propria attachment are amenable for Endoscopic Submucosal Dissection (ESD) which is a minimally invasive procedure when compared to surgical resection. They may require follow-up after resection. Here, we report a case of 39-year-old male who presented with epigastric pain, heart burn and underwent endoscopy for the same, which revealed a sub-centimetric yellowish white flat lesion above oesophago-gastric junction. Biopsy was done and histopathology and immuno-histochemistry revealed sheets of tumour cells with clear granular cytoplasm which stained positive for S100 and Calretinin, with a Ki-67 index of 2%, confirming the diagnosis of a benign GCT. Endoscopic Ultrasound (EUS) revealed no local invasion and the patient was advised three months follow-up and annual surveillance endoscopy.
Non-therapeutic Management of Adhesive Small Bowel Obstruction: A Descriptive Map of Practice Patterns among General Surgeons in Saudi Arabia
Authors: Alzerwi Nasser
Published: February 2021

Introduction: Adhesive Small Bowel Obstruction (ASBO) is a common postoperative complication, and its management is challenging and controversial. Published guidelines for management are inconsistent and therefore, management practices vary based on institutions and individual surgeons. Aim: To evaluate variation of practice patterns among general surgeons and residents in investigation and non-therapeutic management of ASBO. Materials and Methods: This descriptive multi-centric cross-sectional study was done on 250 general surgery trainees and practitioners who were selected to be part of the study between January-February 2020 by simple random sampling. The participants were evaluated by questionnaire method which included standard of care, current practices and variability in non-therapeutic management of ASBO. Results: In total, 198 (79.2%) participants with mean (SD) age and duration of practice 36.5 (7.70) and 9.40 (7.26) years, responded, the majority (60%) of the respondents agreed on the use of routine abdominal Contrast-Enhanced Computed Tomography (CECT) for suspected ASBO. Resuscitation as per haemodynamics was preferred over positive fluid balance by 64.6%; nasogastric drainage was considered mandatory by 76.3% and the passage of flatus was considered the most important determinant of clinical resolution of the obstructive episode by 55.1% of respondents. Around a third of the respondents (36.4%) were of the opinion that resumption of oral intake should begin with sips of water and another 47.5% thought that 48 hours is the maximum waiting period for Non-operative Management (NOM). Conclusion: This study demonstrates that there is high variability between general surgeons in most aspects of ASBO non-therapeutic management. The findings underscore the need for developing national standard consensus-based guidelines to allow timely and effective management of this complex and potentially life-threatening condition.
Pollution Evaluation Based on Physicochemical and Heavy Metal Levels of Miniokoro Stream, Port Harcourt, Nigeria
Authors: Abbey D. M. , Abbey M. E. , Ogunyemi T. C. , Abbey M. E.
Published: February 2021

Evaluation of physicochemical parameters and heavy metal levels in surface water of the Miniokoro stream, Port Harcourt, Nigeria were investigated to determine its potability and pollution status at various stations along the stream.  The physicochemical parameters analyzed in the water samples were: pH, Temperature, Salinity, Electrical conductivity, TDS, DO, BOD, Alkalinity, Chloride, NH4+, NO3-, PO43-, SO42- while heavy metals such as Nickel, lead, Iron, Zinc and Chromium were analyzed using atomic absorption spectrophotometer. The results from the research showed an average concentration level of the physicochemical parameters such as pH (5.79-7.01), EC (136.43 - 960.67µS/cm), TDS (90.17 - 1517.67) and the spatial distribution of heavy metals: zinc (0.07 - 1.09mg/l), chromium (0.03 - 0.09mg/l), nickel (0.07 - 0.08mg/l) and iron (12.29 - 39.95mg/l). Water samples from various stations depicts the varying level of pollution along the stream when compared with national and international permissible limit. Thus, it suggests that the government should develop and implement an effective waste management plans due to environmental and other anthropogenic impacts on the stream.
Physico-Chemical Properties of Purified Carboxylesterase from the Seeds of Tamarindus indica
Authors: Kantharaju S. , Mylarappa M.
Published: February 2021

The present work is focus on physical and chemical properties of purified Carboxylesterase using the Seeds of Tamarindus Indica.The esterases are extracted from the germinating tamarind seeds using 50 mM phosphate buffer, pH 7 and purified. The Km with α-naphthyl acetate, β-naphthyl acetate and α-naphthyl butyrate as the substrates is 28.6 μM, 22.2 μM and 26.7 μM respectively. The Vmax for the same substrates is 7.1 x 10-3 µmole/min, 7.41 x 10-3 µmole/min and 8.00 x 10-3 µmole/min respectively. The enzymes optimally active at pH 7.0 and are stable between pH 5.0 to 8.0. The optimum temperature of esterase activity is 40˚C. The molecular weight of 27.5 kD as determined by SDS-PAGE, both in the presence and absence of β-mercaptothanol and is in close agreement with the molecular weight determined by gel-filtration on Sephadex G-100 (26.9 kD).
A Review Study on Stationary and Non-Stationary IDF Models Used in Rainfall Data Analysis around the World from 1951-2020
Authors: Nwaogazie Ify L. , Sam M. G.
Published: February 2021

This article focuses on an overview of the processes of generating rainfall intensity-duration-frequency (IDF) models, the different types and applications. IDF model is an important tool applied in the design of either hydrologic or hydraulic design such as prediction of rainfall intensities to estimate peak runoff volumes for mitigation of flooding. IDF models evolved from stationary – parametric (empirical) and non-parametric (stochastic) models, to non-stationary models in which variables vary with time. Each category controls the ways models predict rainfall intensities, and reveals their strength and weaknesses. IDF models must therefore, be chosen in terms of the project objective, data availability, size of the study, location, output needed, and the desired simplicity. For instance, while the parametric model predicts better for shorter durations and return periods only, the non-parametric models predict better for both shorter and longer durations and return periods. For projects requiring change of input data over time and evaluation of uncertainty bounds, risk assessment, including incorporation of changes in extreme precipitation, the non-stationary model approach must be selected. Also, of importance for catchments without rainfall amount and corresponding duration records but has daily (24-hourly) record of rainfall depth, the Indian Meteorological Department (IMD) method of shorter duration disaggregation can be adopted to generate in-put data for the development of IDF curves for such a location. Therefore, each model type has limitations that may make it unsuitable for some projects. Reviewing input data and output requirements, and simplicity are all necessary to decide on which model type should be selected.
AN EXPLORATORY INVESTIGATION OF THE USES AND GRATIFICATIONS OF APPS FOR STUDENT LEARNING
Authors: Peters Cara , Bodkin Charles
Published: February 2021

Cell phone usage, particularly app usage, is pervasive among today’s college students. Utilizing the uses and gratifications theory, the current study explores students’ perceptions of the utility of smartphone apps in an educational context. The findings highlight the various types of apps that students use for academic purposes, which apps they perceive to be most important to their success in the classroom, and the apparent usefulness of these apps in both individual and group contexts. Implications of the study for both faculty and students are discussed.