bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemetary Video S3 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Video S3. MDA-MB231 cells on 3D-ECM generated by KO MEFs.
Supplementary Data Figures 1-4 from CD38 in Hairy Cell Leukemia Is a Marker of Poor Prognosis and a New Target for Therapy
Authors: Poret Nicolas , Fu Qiangwei , Guihard Soizic , Cheok Meyling , Miller Katie , Zeng Gordon , Quesnel Bruno , Troussard Xavier , Galiègue-Zouitina Sylvie , Shelley Carl Simon
Published: March 2023

Supplementary Data Figures 1-4. Figure S1: Genomic localization of ZFN target sequences. Figure S2: DNA sequence of wild-type and mutant CD38 genes. Figure S3: Western blot analysis of CD38 protein expression from wild-type and mutant CD38 genes. Figure S4: Flow cytometric analysis of CD38 surface expression from wild-type and mutant CD38 genes.
Supplemental Figure S1 from PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment
Authors: Li Jing , Jie Hyun-Bae , Lei Yu , Gildener-Leapman Neil , Trivedi Sumita , Green Tony , Kane Lawrence P. , Ferris Robert L.
Published: March 2023

Supplemental Figure S1. Variable expression levels of PD-L1 on HNSCC cells.
Supplemental Methods from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: March 2023

Supplemental Methods
Supplemental Figure 4 from Tumor Radiosensitization by Monomethyl Auristatin E: Mechanism of Action and Targeted Delivery
Authors: Buckel Lisa , Savariar Elamprakash N. , Crisp Jessica L. , Jones Karra A. , Hicks Angel M. , Scanderbeg Daniel J. , Nguyen Quyen T. , Sicklick Jason K. , Lowy Andrew M. , Tsien Roger Y. , Advani Sunil J.
Published: March 2023

Tumor xenografts show cleavage dependent tumor contrast with radiometric ACPP.
Supplementary Table 5 from Identification of a Functional SNP in the 3′UTR of CXCR2 That Is Associated with Reduced Risk of Lung Cancer
Authors: Ryan Bríd M. , Robles Ana I. , McClary Andrew C. , Haznadar Majda , Bowman Elise D. , Pine Sharon R. , Brown Derek , Khan Mohammed , Shiraishi Kouya , Kohno Takashi , Okayama Hirokazu , Modali Ramakrishna , Yokota Jun , Harris Curtis C.
Published: March 2023

Risk associations stratified by smoking status.
Supplementary Table S1 from Histone Deacetylase Inhibitors Repress Tumoral Expression of the Proinvasive Factor RUNX2
Authors: Sancisi Valentina , Gandolfi Greta , Ambrosetti Davide Carlo , Ciarrocchi Alessia
Published: March 2023

Supplementary Table S1. Primers and probes sequences.
Supplementary Table 3 from PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Authors: Mohlin Sofie , Hamidian Arash , von Stedingk Kristoffer , Bridges Esther , Wigerup Caroline , Bexell Daniel , Påhlman Sven
Published: March 2023

Supplementary Table 3. siRNA oligos used for transfections.
Supplemmentary Methods from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Supplementary methods Appendix
Supplementary Figure Legends from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Legends to supplementary figures
Supplementary Figure 4 from PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Authors: Mohlin Sofie , Hamidian Arash , von Stedingk Kristoffer , Bridges Esther , Wigerup Caroline , Bexell Daniel , Påhlman Sven
Published: March 2023

Supplementary Figure 4. Inhibition of mTORC1 has no effect on HIF-2α downstream target genes.
Supplementary Figure 9 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

PD-L1/B7-H1 expression on tumor cells is preferentially observed in tumors of the Combo group mice.
Supplementary Figure 7 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Anti-mCD137 and anti-mPD-1 combined antitumor effects are solely CD8 T-cells dependent in a murine colon cancer model.
Supplementary Figure 6 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Urelumab and nivolumab do not exert antitumor effects in the absence of hPBMCs.
Supplementary Figure 1 from PI3K–mTORC2 but not PI3K–mTORC1 Regulates Transcription of HIF2A/EPAS1 and Vascularization in Neuroblastoma
Authors: Mohlin Sofie , Hamidian Arash , von Stedingk Kristoffer , Bridges Esther , Wigerup Caroline , Bexell Daniel , Påhlman Sven
Published: March 2023

Supplementary Figure 1. Knockdown of IGF2R does not affect HIF2A transcription.
Supplemental Figure Legends from Loss of Estrogen-Regulated microRNA Expression Increases HER2 Signaling and Is Prognostic of Poor Outcome in Luminal Breast Cancer
Authors: Bailey Shannon T. , Westerling Thomas , Brown Myles
Published: March 2023

Legends for the supplemental figures.
Supplementary Figure 3 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Timing of peripheral tissue infiltration by transferred human T-lymphocytes into Rag2-/-IL2Rgcnull mice.
Supplementary Figure 2 from Nivolumab and Urelumab Enhance Antitumor Activity of Human T Lymphocytes Engrafted in Rag2−/−IL2Rγnull Immunodeficient Mice
Authors: Sanmamed Miguel F. , Rodriguez Inmaculada , Schalper Kurt A. , Oñate Carmen , Azpilikueta Arantza , Rodriguez-Ruiz Maria E. , Morales-Kastresana Aizea , Labiano Sara , Pérez-Gracia Jose L. , Martín-Algarra Salvador , Alfaro Carlos , Mazzolini Guillermo , Sarno Francesca , Hidalgo Manuel , Korman Alan J. , Jure-Kunkel Maria , Melero Ignacio
Published: March 2023

Urelumab and Nivolumab bind to hCD137 and hPD-1 expressed on human T-lymphocytes engrafted in Rag2-/-IL2Rgcnull mice.
Figure S4 from Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors
Authors: Baird Jason R. , Friedman David , Cottam Benjamin , Dubensky Thomas W. , Kanne David B. , Bambina Shelly , Bahjat Keith , Crittenden Marka R. , Gough Michael J.
Published: March 2023

Figure S4. RT and RR-CDG treatment in a range of tumor models
Figure S1 from Radiotherapy Combined with Novel STING-Targeting Oligonucleotides Results in Regression of Established Tumors
Authors: Baird Jason R. , Friedman David , Cottam Benjamin , Dubensky Thomas W. , Kanne David B. , Bambina Shelly , Bahjat Keith , Crittenden Marka R. , Gough Michael J.
Published: March 2023

Figure S1. RR-CDG and radiation therapy in 3LL
Supplementary Figures S1-S5 and Table S1 from BRCA2-Deficient Sarcomatoid Mammary Tumors Exhibit Multidrug Resistance
Authors: Jaspers Janneke E. , Sol Wendy , Kersbergen Ariena , Schlicker Andreas , Guyader Charlotte , Xu Guotai , Wessels Lodewyk , Borst Piet , Jonkers Jos , Rottenberg Sven
Published: March 2023

Supplementary Figures S1-S5 and Table S1. Fig. S1: BRCA2 and p53 deletion in KB2P tumors. Fig. S2: aCGH clustering of KB2P tumors. Fig. S3: Acquired resistant carcinomas retain their epithelial phenotype. Fig. S4: SAM analysis of KB2P tumors. Fig. S5: EMT score and ABCB1 expression in metaplastic breast cancers. Table S1: EMT signature genes in each data set.
Supplementary Table and Figure Legends from Tumor-Promoting Effects of Myeloid-Derived Suppressor Cells Are Potentiated by Hypoxia-Induced Expression of miR-210
Authors: Noman Muhammad Zaeem , Janji Bassam , Hu Shijun , Wu Joseph C. , Martelli Fabio , Bronte Vincenzo , Chouaib Salem
Published: March 2023

Supplementary Table and Figure Legends. Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S2.
Supplementary Figure 5 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Analysis of the cellular response induced by anti-xCT vaccination
Supplementary Figure 4 from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Soft agar colony formation assay of cells transfected with xCT
Supplementary Table and Figure Legends from Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10
Authors: Allen Joshua E. , Prabhu Varun V. , Talekar Mala , van den Heuvel A. Pieter J. , Lim Bora , Dicker David T. , Fritz Jennifer L. , Beck Adam , El-Deiry Wafik S.
Published: March 2023

Supplementary Table and Figure Legends. Legends for Supplementary Tables S1-S4 and Supplementary Figures S1-S12.
Supplememtary methods from Immunotargeting of Antigen xCT Attenuates Stem-like Cell Behavior and Metastatic Progression in Breast Cancer
Authors: Lanzardo Stefania , Conti Laura , Rooke Ronald , Ruiu Roberto , Accart Nathalie , Bolli Elisabetta , Arigoni Maddalena , Macagno Marco , Barrera Giuseppina , Pizzimenti Stefania , Aurisicchio Luigi , Calogero Raffaele Adolfo , Cavallo Federica
Published: March 2023

Materials and Methods of the supplementary data
Supplemental Table S2 from Perinatal and Familial Risk Factors for Brain Tumors in Childhood through Young Adulthood
Authors: Crump Casey , Sundquist Jan , Sieh Weiva , Winkleby Marilyn A. , Sundquist Kristina
Published: March 2023

Adjusted incidence rate ratios for associations between perinatal or familial characteristics and primitive neuroectodermal tumors in 1973-2010.
Supplementary Figures 1-6 from Targeting LUNX Inhibits Non–Small Cell Lung Cancer Growth and Metastasis
Authors: Zheng Xiaohu , Cheng Min , Fu Binqing , Fan Xiaolei , Wang Qing , Yu Xiaoqing , Sun Rui , Tian Zhigang , Wei Haiming
Published: March 2023

Supplementary Figure 1. Analysis of LunX expression. Supplementary Figure 2. Analysis of lung cancer cell migration and proliferation. Supplementary Figure 3. LunX-interacting proteins and the pathways regulated by LunX. Supplementary Figure 4. LunX-targeted small interfering RNA suppresses lung cancer growth and metastasis. Supplementary Figure 5. Characterization of the LunX therapeutic antibody (S-35-8). Supplementary Figure 6. The LunX antibody (S-35-8) treats lung cancer.
Supplementary Table S1 from Establishment and Characterization of a Cell Line from Human Circulating Colon Cancer Cells
Authors: Cayrefourcq Laure , Mazard Thibault , Joosse Simon , Solassol Jérôme , Ramos Jeanne , Assenat Eric , Schumacher Udo , Costes Valérie , Maudelonde Thierry , Pantel Klaus , Alix-Panabières Catherine
Published: March 2023

Proteins panel tested on the colon CTC-MCC-41 cell line for flow cytometry and immunocytochemistry experiments
Supplementary Figure S4 from IL10 and PD-1 Cooperate to Limit the Activity of Tumor-Specific CD8+ T Cells
Authors: Sun Zhaojun , Fourcade Julien , Pagliano Ornella , Chauvin Joe-Marc , Sander Cindy , Kirkwood John M. , Zarour Hassane M.
Published: March 2023

Supplementary Figure S4. IL-10R blockade does not increase PD-1 expression by NY-ESO-1-specific CD8+ T cells.
Supplementary Figure 4B from Maspin Expression in Prostate Tumor Cells Averts Stemness and Stratifies Drug Sensitivity
Authors: Bernardo M. Margarida , Kaplun Alexander , Dzinic Sijana H. , Li Xiaohua , Irish Jonathan , Mujagic Adelina , Jakupovic Benjamin , Back Jessica B. , Van Buren Eric , Han Xiang , Dean Ivory , Chen Yong Q. , Heath Elisabeth , Sakr Wael , Sheng Shijie
Published: March 2023

Supplementary Figure 4B - Maspin shows no microenvironment dependent effect on prostate cancer cell sensitivity to Rapamycin
Supplemental Figures S1-S5 from An Effective Immuno-PET Imaging Method to Monitor CD8-Dependent Responses to Immunotherapy
Authors: Tavaré Richard , Escuin-Ordinas Helena , Mok Stephen , McCracken Melissa N. , Zettlitz Kirstin A. , Salazar Felix B. , Witte Owen N. , Ribas Antoni , Wu Anna M.
Published: March 2023

Supplemental Figures S1-S5: Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the OT-I adoptive T cell therapy model: transverse images (S1); Alterations in inguinal lymph node and spleen weights after differing immunotherapeutic treatment (S2); Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the CT26/anti-CD137 immunotherapy model: transverse images (S3); CD8 IHC on untreated CT26 xenografts (S4); Anti-CD8 immunoPET of 89Zr-malDFO-169 cDb in the CT26/anti-PD-L1 immunotherapy model: transverse images (S5).
Supplementary Tables S1-S4 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: March 2023

Supplementary Tables S1-S4 Supplementary Table S1. Antibodies used in the paper. Supplementary Table S2. Primers for qRT-PCR and quantitative ChIP. Supplementary Table S3. The percentage of cells in spleen of naïve WT and Cul4b CKO mice Supplementary Table S4. The percentage of cells in bone marrow of naïve WT and Cul4b CKO mice.
Supplementary Figure S4 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer
Authors: Thewes Verena , Simon Ronald , Schroeter Petra , Schlotter Magdalena , Anzeneder Tobias , Büttner Reinhard , Benes Vladimir , Sauter Guido , Burwinkel Barbara , Nicholson Robert I. , Sinn Hans-Peter , Schneeweiss Andreas , Deuschle Ulrich , Zapatka Marc , Heck Stefanie , Lichter Peter
Published: March 2023

Supplementary Figure S4. AIB1 in tamoxifen- and fulvestrant-resistant breast cancer cells.
Supplementary Figure S2 from The CUL4B/AKT/β-Catenin Axis Restricts the Accumulation of Myeloid-Derived Suppressor Cells to Prohibit the Establishment of a Tumor-Permissive Microenvironment
Authors: Qian Yanyan , Yuan Jupeng , Hu Huili , Yang Qifeng , Li Jisheng , Zhang Shuqian , Jiang Baichun , Shao Changshun , Gong Yaoqin
Published: March 2023

Supplementary Figure S2. Activation and immune effect of CD8+ T cells and NK cells.
Supplementary Figure S2 from Reprogramming of the ERRα and ERα Target Gene Landscape Triggers Tamoxifen Resistance in Breast Cancer
Authors: Thewes Verena , Simon Ronald , Schroeter Petra , Schlotter Magdalena , Anzeneder Tobias , Büttner Reinhard , Benes Vladimir , Sauter Guido , Burwinkel Barbara , Nicholson Robert I. , Sinn Hans-Peter , Schneeweiss Andreas , Deuschle Ulrich , Zapatka Marc , Heck Stefanie , Lichter Peter
Published: March 2023

Supplementary Figure S2. Chromatin immunoprecipitation (ChIP).
supplementary figures from Serum Immunoregulatory Proteins as Predictors of Overall Survival of Metastatic Melanoma Patients Treated with Ipilimumab
Authors: Koguchi Yoshinobu , Hoen Helena M. , Bambina Shelly A. , Rynning Michael D. , Fuerstenberg Richard K. , Curti Brendan D. , Urba Walter J. , Milburn Christina , Bahjat Frances Rena , Korman Alan J. , Bahjat Keith S.
Published: March 2023

Figure S1A. Kaplan-Meier plot of survival by CXCL11 group for gp100-treated melanoma patients Figure S1B. Kaplan-Meier plot of survival by CXCL11 group for ipilimumab-treated melanoma patients Figure S1C. Kaplan-Meier plot of survival by MICA group for gp100-treated melanoma patients Figure S1D. Kaplan-Meier plot of survival by MICA group for ipilimumab-treated melanoma patients Figure S1E. Kaplan-Meier plot of survival by VEGF group for gp100-treated melanoma patients Figure S1F. Kaplan-Meier plot of survival by VEGF group for ipilimumab-treated melanoma patients Figure S2A. Kaplan-Meier plot of survival by CXCL11, Compassionate use study Figure S2B. Kaplan-Meier plot of survival by MICA, Compassionate use study Figure S2C. Kaplan-Meier plot of survival by VEGF, Compassionate use study
Supplementary Figure 6 from Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression
Authors: Anz David , Rapp Moritz , Eiber Stephan , Koelzer Viktor H. , Thaler Raffael , Haubner Sascha , Knott Max , Nagel Sarah , Golic Michaela , Wiedemann Gabriela M. , Bauernfeind Franz , Wurzenberger Cornelia , Hornung Veit , Scholz Christoph , Mayr Doris , Rothenfusser Simon , Endres Stefan , Bourquin Carole
Published: March 2023

Supplementary Figure 6-Type I interferon is a key mediator in the process of CCL22 suppression and tumor regression.
Supplementary Figure legends from Novel Mechanism of Macrophage-Mediated Metastasis Revealed in a Zebrafish Model of Tumor Development
Authors: Wang Jian , Cao Ziquan , Zhang Xing-Mei , Nakamura Masaki , Sun Meili , Hartman Johan , Harris Robert A. , Sun Yuping , Cao Yihai
Published: March 2023

Supplementary Figure legends
Supplementary Figure S3 from eIF4E Threshold Levels Differ in Governing Normal and Neoplastic Expansion of Mammary Stem and Luminal Progenitor Cells
Authors: Avdulov Svetlana , Herrera Jeremy , Smith Karen , Peterson Mark , Gomez-Garcia Jose R. , Beadnell Thomas C. , Schwertfeger Kathryn L. , Benyumov Alexey O. , Manivel J. Carlos , Li Shunan , Bielinsky Anja-Katrin , Yee Douglas , Bitterman Peter B. , Polunovsky Vitaly A.
Published: March 2023

Supplementary Fig. S3. Double K8/Ki-67staining of wild type (WT) and transgenic (WAP-4E) mammary glands (gestation 6).
Figure S3 from Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7
Authors: Adinolfi Elena , Capece Marina , Franceschini Alessia , Falzoni Simonetta , Giuliani Anna L. , Rotondo Alessandra , Sarti Alba C. , Bonora Massimo , Syberg Susanne , Corigliano Domenica , Pinton Paolo , Jorgensen Niklas R. , Abelli Luigi , Emionite Laura , Raffaghello Lizzia , Pistoia Vito , Di Virgilio Francesco
Published: March 2023

Figure S3. Effect of P2X7R deletion on VEGF release. A, in vitro VEGF release from wt or P2X7R-silenced B16 cells. B, intra-tumor VEGF content of B16-wt or P2X7R-silenced tumors grown in wt or P2X7R-KO mice. VEGF was measured by ELISA. A, * p < 0.05 for B16 shRNA vs B16-wt. B, * p < 0.05 for P2X7R-wt + B16 shRNA vs P2X7R-wt + B16-wt; {section sign}{section sign} p < 0.01 for P2X7R-KO + B16 shRNA vs P2X7R-KO + B16-wt. C-F, VEGF staining of tumors from P2X7R-KO (C and D) or wt (E and F) mice. Specimens were fixed and stained with the anti-VEGF Ab as described in Materials and Methods.
Supplementary Figure S5 from miR-124 and Androgen Receptor Signaling Inhibitors Repress Prostate Cancer Growth by Downregulating Androgen Receptor Splice Variants, EZH2, and Src
Authors: Shi Xu-Bao , Ma Ai-Hong , Xue Lingru , Li Meimei , Nguyen Hao G. , Yang Joy C. , Tepper Clifford G. , Gandour-Edwards Regina , Evans Christopher P. , Kung Hsing-Jien , deVere White Ralph W.
Published: March 2023

Immunostaining of AR-V7 in CWR22 xenografts.
Supplemental Figure S7 from Akt Inhibition Enhances Expansion of Potent Tumor-Specific Lymphocytes with Memory Cell Characteristics
Authors: Crompton Joseph G. , Sukumar Madhusudhanan , Roychoudhuri Rahul , Clever David , Gros Alena , Eil Robert L. , Tran Eric , Hanada Ken-ichi , Yu Zhiya , Palmer Douglas C. , Kerkar Sid P. , Michalek Ryan D. , Upham Trevor , Leonardi Anthony , Acquavella Nicolas , Wang Ena , Marincola Francesco M. , Gattinoni Luca , Muranski Pawel , Sundrud Mark S. , Klebanoff Christopher A. , Rosenberg Steven A. , Fearon Douglas T. , Restifo Nicholas P.
Published: March 2023

Supplemental Figure S7. Pharmacologic inhibition of Akt modulates global metabolic profile and key lipid metabolites of antigen-experienced murine CD8+ T cells.
Supplementary Figure S3 from Immuno-PET Imaging of Engineered Human T Cells in Tumors
Authors: Mall Sabine , Yusufi Nahid , Wagner Ricarda , Klar Richard , Bianchi Henrique , Steiger Katja , Straub Melanie , Audehm Stefan , Laitinen Iina , Aichler Michaela , Peschel Christian , Ziegler Sibylle , Mustafa Mona , Schwaiger Markus , D'Alessandria Calogero , Krackhardt Angela M.
Published: March 2023

Investigation of dynamics of tumor rejection mediated by TCR2.5D6-transduced TCM to determine biologically critical imaging time points in an ML2-based myeloid sarcoma model
Supplementary Table 1 from Evaluating Patient-Derived Colorectal Cancer Xenografts as Preclinical Models by Comparison with Patient Clinical Data
Authors: Nunes Manoel , Vrignaud Patricia , Vacher Sophie , Richon Sophie , Lièvre Astrid , Cacheux Wulfran , Weiswald Louis-Bastien , Massonnet Gerald , Chateau-Joubert Sophie , Nicolas André , Dib Colette , Zhang Weidong , Watters James , Bergstrom Donald , Roman-Roman Sergio , Bièche Ivan , Dangles-Marie Virginie
Published: March 2023

Genomic alterations in KRAS/BRAF/NRA S wild-type xenografts, according to their response to cetuximab. Tumors were considered to be amplified if the gene copy number was >3. Gene overexpression is defined by an expression superior to average in all PDX panel + 1 SD.
Supplementary Figure S1 from Immuno-PET Imaging of Engineered Human T Cells in Tumors
Authors: Mall Sabine , Yusufi Nahid , Wagner Ricarda , Klar Richard , Bianchi Henrique , Steiger Katja , Straub Melanie , Audehm Stefan , Laitinen Iina , Aichler Michaela , Peschel Christian , Ziegler Sibylle , Mustafa Mona , Schwaiger Markus , D'Alessandria Calogero , Krackhardt Angela M.
Published: March 2023

Principle of targeting of TCR2.5D6-transduced T cells by aTCRmu-IgG and aTCRmu-F(ab')2
Supplementary Table S3 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: March 2023

List of significantly up-regulated gene sets.
Supplementary Table S1 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: March 2023

List of published p53 targets used for transcriptomic analysis.
Supplementary Table 4 from Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Authors: Sharma Ashwini Kumar , Eils Roland , König Rainer
Published: March 2023

List of predicted metabolic cancer genes with significant knock down results in cell lines.
Supplementary Table 3 from Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Authors: Sharma Ashwini Kumar , Eils Roland , König Rainer
Published: March 2023

List of predicted metabolic cancer genes
Supplementary Table S3 from PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells
Authors: Rahme Gilbert J. , Zhang Zhonghua , Young Alison L. , Cheng Chao , Bivona Eric J. , Fiering Steven N. , Hitoshi Yasuyuki , Israel Mark A.
Published: March 2023

ShRNA sequences used.
Supplementary Figure 7 from Copy Number Alterations in Enzyme-Coding and Cancer-Causing Genes Reprogram Tumor Metabolism
Authors: Sharma Ashwini Kumar , Eils Roland , König Rainer
Published: March 2023

Heatmap of core metabolic gene set.
Supplementary Figures S1-S7 from PDGF Engages an E2F-USP1 Signaling Pathway to Support ID2-Mediated Survival of Proneural Glioma Cells
Authors: Rahme Gilbert J. , Zhang Zhonghua , Young Alison L. , Cheng Chao , Bivona Eric J. , Fiering Steven N. , Hitoshi Yasuyuki , Israel Mark A.
Published: March 2023

Diagram depicting mouse transgenic alleles in PDGF-driven GBM model (S1); Gene expression analysis of PDGF-driven murine glioma and alignment with human GBM (S2); USP1 expression in GBM (S3); PDGF-B drives the expression of USP1 in mouse NSCs (S4); Schematic representation of the murine USP1 promoter segments used in reporter assays (S5); mRNA expression of Id genes in PDGF-GSCs (S6); Examination of deletion of the Id2 gene locus by Gfap-Cre in vivo and in derived primary cells (S7).
Supplementary Figure S7 from CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling
Authors: Jiang Feng , Chen Lei , Yang Ying-Cheng , Wang Xian-ming , Wang Ruo-Yu , Li Liang , Wen Wen , Chang Yan-Xin , Chen Cai-Yang , Tang Jing , Liu Gao-Mi-Yang , Huang Wen-Tao , Xu Lin , Wang Hong-Yang
Published: March 2023

Supplementary Figure S7: ROS enrichment and the dissociation of mTOR-Ribosome are necessary for the function of CYP3A5
Supplementary table and figure legends from The Deubiquitinase USP9X Maintains DNA Replication Fork Stability and DNA Damage Checkpoint Responses by Regulating CLASPIN during S-Phase
Authors: McGarry Edel , Gaboriau David , Rainey Michael D. , Restuccia Umberto , Bachi Angela , Santocanale Corrado
Published: March 2023

Supplementary table and figure legends.
Supplementary Figure S5 from CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling
Authors: Jiang Feng , Chen Lei , Yang Ying-Cheng , Wang Xian-ming , Wang Ruo-Yu , Li Liang , Wen Wen , Chang Yan-Xin , Chen Cai-Yang , Tang Jing , Liu Gao-Mi-Yang , Huang Wen-Tao , Xu Lin , Wang Hong-Yang
Published: March 2023

Supplementary Figure S5: AKT inhibitor-treated cells are not sensitive to CYP3A5-manipulated cell phenotype
Supplementary Figure S4 from CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling
Authors: Jiang Feng , Chen Lei , Yang Ying-Cheng , Wang Xian-ming , Wang Ruo-Yu , Li Liang , Wen Wen , Chang Yan-Xin , Chen Cai-Yang , Tang Jing , Liu Gao-Mi-Yang , Huang Wen-Tao , Xu Lin , Wang Hong-Yang
Published: March 2023

Supplementary Figure S4: Ectopic expression of CYP3A5 ameliorates HCC migration and AKT phosphorylation
Supplementary Figure S1 from CYP3A5 Functions as a Tumor Suppressor in Hepatocellular Carcinoma by Regulating mTORC2/Akt Signaling
Authors: Jiang Feng , Chen Lei , Yang Ying-Cheng , Wang Xian-ming , Wang Ruo-Yu , Li Liang , Wen Wen , Chang Yan-Xin , Chen Cai-Yang , Tang Jing , Liu Gao-Mi-Yang , Huang Wen-Tao , Xu Lin , Wang Hong-Yang
Published: March 2023

Supplementary Figure S1: The expression of CYP3A5 in tissues and cell lines
Supplementary Table and Figure Legends from RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation
Authors: Yoldi Guillermo , Pellegrini Pasquale , Trinidad Eva M. , Cordero Alex , Gomez-Miragaya Jorge , Serra-Musach Jordi , Dougall William C. , Muñoz Purificación , Pujana Miguel-Angel , Planelles Lourdes , González-Suárez Eva
Published: March 2023

Legend for Supplementary Table S1 and Supplementary Figures S1-S5.
Supplementary Figure S5 from RANK Signaling Blockade Reduces Breast Cancer Recurrence by Inducing Tumor Cell Differentiation
Authors: Yoldi Guillermo , Pellegrini Pasquale , Trinidad Eva M. , Cordero Alex , Gomez-Miragaya Jorge , Serra-Musach Jordi , Dougall William C. , Muñoz Purificación , Pujana Miguel-Angel , Planelles Lourdes , González-Suárez Eva
Published: March 2023

Knock-down and overexpression of Tfap2b and Knock down of Rank
Supplemental Methods from Caspase-9b Interacts Directly with cIAP1 to Drive Agonist-Independent Activation of NF-κB and Lung Tumorigenesis
Authors: Vu Ngoc T. , Park Margaret A. , Shultz Michael D. , Bulut Gamze B. , Ladd Amy C. , Chalfant Charles E.
Published: March 2023

Methods used for Supplemental Data only: WST-1 cell proliferation assay, Ki-67 mmunohistochemical analysis
Supplementary Movie S1B from Novel Morphologic and Genetic Analysis of Cancer Cells in a 3D Microenvironment Identifies STAT3 as a Regulator of Tumor Permeability Barrier Function
Authors: Park Min Chul , Jeong Hyobin , Son Sung Hwa , Kim YounHa , Han Daeyoung , Goughnour Peter C. , Kang Taehee , Kwon Nam Hoon , Moon Hyo Eun , Paek Sun Ha , Hwang Daehee , Seol Ho Jun , Nam Do-Hyun , Kim Sunghoon
Published: March 2023

Spheroid formation of cancer cells - H460 (M)
Supplementary methods from SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression
Authors: Tanaka Masamitsu , Shimamura Shintaro , Kuriyama Sei , Maeda Daichi , Goto Akiteru , Aiba Namiko
Published: March 2023

Supplementary materials and methods
Supplementary figure 7 from SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression
Authors: Tanaka Masamitsu , Shimamura Shintaro , Kuriyama Sei , Maeda Daichi , Goto Akiteru , Aiba Namiko
Published: March 2023

SKAP2 expression in CAFs.
Supplementary figure 6 from SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression
Authors: Tanaka Masamitsu , Shimamura Shintaro , Kuriyama Sei , Maeda Daichi , Goto Akiteru , Aiba Namiko
Published: March 2023

Cleaved caspase-3 staining of lung tumors.
Supplementary figure 5 from SKAP2 Promotes Podosome Formation to Facilitate Tumor-Associated Macrophage Infiltration and Metastatic Progression
Authors: Tanaka Masamitsu , Shimamura Shintaro , Kuriyama Sei , Maeda Daichi , Goto Akiteru , Aiba Namiko
Published: March 2023

Ki-67 staining of lung tumors.
Supplementary Table S6 from Identification of Patients with Recurrent Glioblastoma Who May Benefit from Combined Bevacizumab and CCNU Therapy: A Report from the BELOB Trial
Authors: Erdem-Eraslan Lale , van den Bent Martin J. , Hoogstrate Youri , Naz-Khan Hina , Stubbs Andrew , van der Spek Peter , Böttcher René , Gao Ya , de Wit Maurice , Taal Walter , Oosterkamp Hendrika M. , Walenkamp Annemiek , Beerepoot Laurens V. , Hanse Monique C.J. , Buter Jan , Honkoop Aafke H. , van der Holt Bronno , Vernhout René M. , Smitt Peter A.E. Sillevis , Kros Johan M. , French Pim J.
Published: March 2023

Fusion genes.
Supplemental Figure Legends from EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1
Authors: Zhang Ying , Wang Shuling , Li Lingsong
Published: March 2023

Supplemental Figure Legends
Supplemental Figure 1 from EF Hand Protein IBA2 Promotes Cell Proliferation in Breast Cancers via Transcriptional Control of Cyclin D1
Authors: Zhang Ying , Wang Shuling , Li Lingsong
Published: March 2023

Supplemental Figure 1
supplementary methods from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: March 2023

supplementary methods
Supplemental Figure Legends from BAFF and APRIL from Activin A–Treated Dendritic Cells Upregulate the Antitumor Efficacy of Dendritic Cells In Vivo
Authors: Shurin Michael R. , Ma Yang , Keskinov Anton A. , Zhao Ruijing , Lokshin Anna , Agassandian Marianna , Shurin Galina V.
Published: March 2023

Supplemental Figure Legends
Figure S3 from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: March 2023

Biological replicates of ChIP-seq analyses for ERalpha (A), RNA Polymerase II (B), H3K27Ac (C) and FOXA1 (D).
Figure S1 from Comparative Cistromics Reveals Genomic Cross-talk between FOXA1 and ERα in Tamoxifen-Associated Endometrial Carcinomas
Authors: Droog Marjolein , Nevedomskaya Ekaterina , Kim Yongsoo , Severson Tesa , Flach Koen D. , Opdam Mark , Schuurman Karianne , Gradowska Patrycja , Hauptmann Michael , Dackus Gwen , Hollema Harry , Mourits Marian J. , Nederlof Petra , van Boven Hester , Linn Sabine C. , Wessels Lodewyk , van Leeuwen Flora E. , Zwart Wilbert
Published: March 2023

Validation of two FOXA1 antibodies that were used for either ChIP or immunohistochemistry.
Supplementary Figures 1 through 5 and Supplementary Figure Legends from p53 Loss in MYC-Driven Neuroblastoma Leads to Metabolic Adaptations Supporting Radioresistance
Authors: Yogev Orli , Barker Karen , Sikka Arti , Almeida Gilberto S. , Hallsworth Albert , Smith Laura M. , Jamin Yann , Ruddle Ruth , Koers Alexander , Webber Hannah T. , Raynaud Florence I. , Popov Sergey , Jones Chris , Petrie Kevin , Robinson Simon P. , Keun Hector C. , Chesler Louis
Published: March 2023

Supplementary Figure 1. The p53 pathway is functional in Th-MYCN neuroblastomas. Supplementary Figure 2. Immunohistochemical analysis of Th-MYCN mice. Supplementary Figure 3. Restoration of p53 has no effect on tumor growth rate or penetration in Th-MYCN/Trp53KI/KI mice. Supplementary Figure 4. Th-MYCN/Trp53KI/KI pups display increased percentage of neoplastic islands compared to Th-MYCN/Trp53WT/WT pups. Supplementary Figure 5. Figure S5 Th-MYCN/Trp53WT/WT and Th-MYCN/Trp53KI/K tumors are similar in their basal DNA damage levels.
Supplementary methods from miR-146b-5p within BCR-ABL1–Positive Microvesicles Promotes Leukemic Transformation of Hematopoietic Cells
Authors: Zhang Hong-Mei , Li Qing , Zhu Xiaojian , Liu Wei , Hu Hui , Liu Teng , Cheng Fanjun , You Yong , Zhong Zhaodong , Zou Ping , Li Qiubai , Chen Zhichao , Guo An-Yuan
Published: March 2023

Supplementary methods for sequencing, regular data analysis and routine experimental methods including primer sequences.
Supplementary Methods and Figures 1 - 11 from BMX Negatively Regulates BAK Function, Thereby Increasing Apoptotic Resistance to Chemotherapeutic Drugs
Authors: Fox Joanna L. , Storey Alan
Published: March 2023

Supplementary Figure S1. Controls for co-immunoprecipitation of BAK-BMX complex. Supplementary Figure S2. Immunoprecipitation of BMX protein from HT1080 cells did not detect BAX associated with BMX. Input for immunoprecipitation reaction is 10% starting protein. Supplementary Figure S3. Representative images of proximity ligation in situ assay (PLISA) in HT1080 cells. Supplementary Figure S4. Immunoprecipitation of BMX protein from HT1080 cells used in in vitro kinase assay (Figure 1E). Input for immunoprecipitation reaction is 10% starting protein. Supplementary Figure S5. Representative images of BMX immunostaining in sections of prostate cancer tissue microarrays showing examples of low and high BMX reactivity in tumor tissue. Supplementary Figure S6. Immunoprecipitation of PTPN21 from HT1080 cells, then western blotted for BMX showing PTPN21-BMX interact in our model system. Supplementary Figure S7. Determination of PTPN21 knockdown in HT1080 cells following A) siRNA or B) shRNA treatment by qRT-PCR. Change in C(T) relative to the parental cells is plotted (for siRNA n=2, + range; for shRNA n=3, + SD). Supplementary Figure S8. A) Knockdown of PTPN21 increases BAK activation in response to UV damage. B) Knockdown of PTPN21 using 2 different shRNA sequences increases BAK activation in response to camptothecin damage. Supplementary Figure S9. Mean percentage of cells undergoing apoptosis as determined by Annexin V positivity by FACS analysis of HT1080 cells stably transfected with shRNA HuSH43 to knockdown PTPN21 expression over a 24 hour time course of CPT treatment (n=3, + SEM, * p<0.05). Supplementary Figure S10. Silencing of BMX expression in HT1080 cells. Supplementary Figure S11. BMX over-expression in HT1080 cells.
Supplementary Tables 1 and 2 and Supplementary Figures 1 through 5 from The Dual MEK/FLT3 Inhibitor E6201 Exerts Cytotoxic Activity against Acute Myeloid Leukemia Cells Harboring Resistance-Conferring FLT3 Mutations
Authors: Zhang Weiguo , Borthakur Gautam , Gao Chen , Chen Ye , Mu Hong , Ruvolo Vivian R. , Nomoto Kenichi , Zhao Nanding , Konopleva Marina , Andreeff Michael
Published: March 2023

Supplementary Table 1. Gene alterations and cytogenic information of AML patients. Supplementary Table 2. Comparison of IC50s of E6201 and AC220 in murine ITD mutant and TKDs mutant cell lines. Fig. S1. Molecular structures of drugs used in this study. Fig. S2. Normal bone marrow samples (three cases) were treated with indicated concentration of E6201 for 72 hours and apoptosis induction was measured by stained with annexin V-Fluo and counting annexin V positivity using flow cytometry. Fig. S3. Body weight of mice was measured at Day 4, in which the mice started E6201 (n = 11) or vehicle (n = 10) treatment, and Day 18 after MOLM13-Luci-GFP cells injection. Fig. S4. Baf3-ITD+691 cells were treated with E6201 for 1 hour and protein profiling of correlated signaling pathways was determined using immunoblotting. Fig. S5. OCI/AML3 and MOLM13 p53 knock down (KD) cells and their respective controls were treated with E6201 for E6201 for 72 hour and apoptosis induction were assessed as the percentage of annexin V-positive cells by flow cytometry.
Supplementary Materials and Methods from Galectin-3 Cleavage Alters Bone Remodeling: Different Outcomes in Breast and Prostate Cancer Skeletal Metastasis
Authors: Nakajima Kosei , Kho Dhong Hyo , Yanagawa Takashi , Harazono Yosuke , Hogan Victor , Chen Wei , Ali-Fehmi Rouba , Mehra Rohit , Raz Avraham
Published: March 2023

Materials and Methods for Tissue microarray, Immunofluorescence, Quantitative Real-Time PCR, Proteomics analysis, Co-immunoprecipitation, Co-culture.
Supplemental Figure 1 from STAT3 Establishes an Immunosuppressive Microenvironment during the Early Stages of Breast Carcinogenesis to Promote Tumor Growth and Metastasis
Authors: Jones Laura M. , Broz Miranda L. , Ranger Jill J. , Ozcelik John , Ahn Ryuhjin , Zuo Dongmei , Ursini-Siegel Josie , Hallett Michael T. , Krummel Matthew , Muller William J.
Published: March 2023

Supplemental Figure 1: Confirmation of specific Stat3 ablation in the epithelium.
Supplementary Table 2 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: March 2023

PI3Kβi (rac-KIN-193) treatment induces the interaction of p85 with a panel of proteins in PTENLOF/BRAFMUT melanoma. RVH-421 were treated with DMSO or 1μM PI3Kβi for 2h. Lysates were subjected to immunoprecipitation using an antibody targeting p85. Proteins in the range of 75 to 250 kDa were identified by LC-MS as described. Total spectra counts were used as a measure for protein quantity. The table summarizes the proteins enriched upon PI3Kβi treatment in the p85 precipitate. A spectral count ratio of 4 (log2 (PI3Kβi /DMSO) > 2) was taken as an arbitrary cutoff for significant enrichment.
Supplementary Figure S1 from Mass Spectrometry–Based Metabolomics Identifies Longitudinal Urinary Metabolite Profiles Predictive of Radiation-Induced Cancer
Authors: Cook John A. , Chandramouli Gadisetti V.R. , Anver Miriam R. , Sowers Anastasia L. , Thetford Angela , Krausz Kristopher W. , Gonzalez Frank J. , Mitchell James B. , Patterson Andrew D.
Published: March 2023

Kaplan-Meier survival plots for mice receiving 0 Gy or 5.4 Gy TBI.
Supplementary Figure 4 from Maximizing the Efficacy of MAPK-Targeted Treatment in PTENLOF/BRAFMUT Melanoma through PI3K and IGF1R Inhibition
Authors: Herkert Barbara , Kauffmann Audrey , Mollé Sandra , Schnell Christian , Ferrat Thomas , Voshol Hans , Juengert Janina , Erasimus Hélène , Marszalek Grégory , Kazic-Legueux Malika , Billy Eric , Ruddy David , Stump Mark , Guthy Daniel , Ristov Mitko , Calkins Keith , Maira Sauveur-Michel , Sellers William R. , Hofmann Francesco , Hall Michael N. , Brachmann Saskia M.
Published: March 2023

IGF1R inhibition synergizes with PI3Kβ inhibition in WM-266-4, but not in A-375. A) Synergistic proliferation inhibition upon PI3K/IGF1R inhibitor combination in WM-266-4 cells. WM-266-4 cells were treated with increasing concentrations of PI3Ki and IGF1Ri as single-agents or in combination with a fixed concentration of 1.1μM IGF1Ri. The data shown represents the mean ({plus minus}SEM) of two replicates. B) + C) Determination of PI3K/IGF1R inhibitor synergy in WM-266-4 (B) and A-375 (C) using proliferation assays. Dose matrices highlight percentages of proliferation inhibition relative to DMSO with 100 indicating complete block of proliferation and >100 indicative of cell death. SS, synergy score. PI3Kβi1/2=rac-KIN-193/GSK-2636771, panPI3Ki=GDC0941, PI3Kαi=BYL719, IGF1Ri=AEW541
Supplementary method from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: March 2023

This file contains supplementary description regarding the materials and methods we used in this study, including lentivirus construction and cell transfection, real-time PCR, reagents, tissue microarray and immunohistochemistry, immunoprecipitation, western blot analysis, immunofluorescence, wound healing, transwell migration, and invasion assays.
Supplementary Table 6 from Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas
Authors: Tang Xiaohu , Wu Jianli , Ding Chien-Kuang , Lu Min , Keenan Melissa M. , Lin Chao-Chieh , Lin Chih-An , Wang Charles C. , George Daniel , Hsu David S. , Chi Jen-Tsan
Published: March 2023

Supplementary Table 6. shRNAs and siRNA information
Supplementary Table 3 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: March 2023

Supplementary Table 3: Univariate analysis of overall survival at 5-year follow-up.
Supplementary Table 1 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: March 2023

Supplementary Table 1:Clinicopathologic characteristics of CRC patients.
Supplementary Figure 2 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: March 2023

Supplementary Figure 2: Both E-cadherin and membrane β-catenin are downregulated in CRC.
Supplementary Figure 1 from PDLIM1 Stabilizes the E-Cadherin/β-Catenin Complex to Prevent Epithelial–Mesenchymal Transition and Metastatic Potential of Colorectal Cancer Cells
Authors: Chen Hai-Ning , Yuan Kefei , Xie Na , Wang Kui , Huang Zhao , Chen Yan , Dou Qianhui , Wu Min , Nice Edouard C. , Zhou Zong-Guang , Huang Canhua
Published: March 2023

Supplementary Figure 1: Loss of PDLIM1 promotes colorectal cancer (CRC) cells migration in vitro.
Table S7 from Integrative Genome-Scale Analysis Identifies Epigenetic Mechanisms of Transcriptional Deregulation in Unfavorable Neuroblastomas
Authors: Henrich Kai-Oliver , Bender Sebastian , Saadati Maral , Dreidax Daniel , Gartlgruber Moritz , Shao Chunxuan , Herrmann Carl , Wiesenfarth Manuel , Parzonka Martha , Wehrmann Lea , Fischer Matthias , Duffy David J. , Bell Emma , Torkov Alica , Schmezer Peter , Plass Christoph , Höfer Thomas , Benner Axel , Pfister Stefan M. , Westermann Frank
Published: March 2023

Genes that significantly i) lost H3K27me3 coverage ii) lost DNA methylation iii) gained expression in Be(2)-C and IMR5-75 cells upon combination treatment with DAC and EPZ-6438
Suppl Table 1 from A Preclinical Model of Malignant Peripheral Nerve Sheath Tumor-like Melanoma Is Characterized by Infiltrating Mast Cells
Authors: Hölzel Michael , Landsberg Jennifer , Glodde Nicole , Bald Tobias , Rogava Meri , Riesenberg Stefanie , Becker Albert , Jönsson Göran , Tüting Thomas
Published: March 2023

Supplementary Table 1. Results of the gene set enrichment analysis (GSEA) from the comparison of amelanotic MPNST-like versus pigmented mouse melanomas.