bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECT OF RETIREMENT ON THE PREVALENCE OF DEPRESSION IN BABYLON GOVERNORATE/ IRAQ 2022
Authors:   M.B.Ch.B., F.I.C.M.S., Abduljabbar F. Abdulmuttaleb
Published: May 2023

Background: Retirement is an important turning point in an individuals life and also a significant social stressor that can have an impact on physical and mental health, moving from a relatively busy and regular lifestyle to a relatively inactive one is a challenge, and the change of roles might be a trigger for some retirees to develop mental health problems, on the other hand, retirement provides people with more leisure time and opportunities as well as freedom from the stress of work, which might improve their mental health, however the relationship between retirement and mental health can vary by the type of retirement and country. Objectives: To assess the association between retirement and the prevalence of depression in Iraq Babylon 2022 Methods: Data was collected in a cross-sectional study at different district of Babylon health department primary health care centers for a period of four months, from September 2022 and ended at the end of November 2022, and included 250 participants, The questionnaire contained a depression scale that contained 8 questions, according to the total score before and after retirement the participant is either diagnosed to have depression or below the diagnostic score of 4. Results: 33 patients had depression before retirement (13.2 %), the number of patients raise to 51 (20.4 %) after retirement (Relative risk = 1.54). Conclusions: The prevalence of depression increase after retirement, the prevalence risk raised by 7.2 % after retirement, relative risk = 1.54.
GRAFTS AND GRAFTING TECHNIQUES IN IMPLANTS - A REVIEW
Authors: Harikrishna M. , Bhargavi K. , Ravi Shankar Y. , Srinivas K. , Vasavi Prasanna G. , Roja Ch.
Published: May 2023

Bone graft is the gold standard materials used for repairing bony defects. There are various bone graft materials/biomaterials and methods available for bone augmentation. The present article explains in detail about bone grafts and the recent advancements in bone graft materials as well as bone augmentation in implant dentistry.The literature search was performed for relevant articles on bone grafts for dental implants in PubMed/Medline, Scopus, Google Scholar, and Science Direct published in English literature published between January 2005 and March 2023. Relevant studies on bone grafts for dental implants were also included and critically analyzed in this review. Various biomaterials can be used to augment bone for implant placement. Each graft procedure has its own advantages and disadvantages in each clinical application and should choose the graft material carefully to attain a high success rate and less morbidity.
TO WHAT EXTENT ARE GENDER STEREOTYPES PORTRAYED THROUGH ADVERTISEMENTS AND HOW CAN THEY INFLUENCE CONSUMER COGNITION?
Authors: Singh Rhea
Published: May 2023

The portrayal of genders in marketing, specifically advertising, can in many ways be demeaning, objectifying, and sexualizing. By repeatedly reaching consumers, advertisements can substantially influence their perceptions. While some advertisements may be educational, others reinforce gender norms by abiding by them. This research paper aims to address advertisements where such oppressive depictions are evident, to evaluate the psychological effect on consumer perception, and to explain what their perception may transform into. The selection of this topic finds root in the desire to advocate and promote Gender Equality. Applying the learnings from the AP Psychology curriculum, the aim is to evaluate gender depictions in product advertising and analyse how the sexes, male and female, are presented in two distinct manners and why this characterization is flawed. Advertisements for household products, perfumes, cars, and other products will be analysed. The gender stereotypes will not be analysed in terms of psychological manners. However, they will explain why and how consumers may perceive gender stereotypes by referring to a list of gender norms.
COMPARATIVE STUDY OF SHEET RESISTANCE BETWEEN SILICON DOPED N AND SILICON P IN DARK AND NO APPLY VOLTAGE
Authors:   Research, Department of Physics, Cheikh Anta Diop University, Dakar Senegal., Diaw Alassane , Touty Traore Papa ,   Research, Department of Physics, Cheikh Anta Diop University, Dakar Senegal., Ndiaye Mor ,   Research, Department of Physics, Cheikh Anta Diop University, Dakar Senegal., Diagne Issa ,   Research, Department of Physics, Cheikh Anta Diop University, Dakar Senegal.
Published: May 2023

The aim of the study is to compare the sheet resistance between silicon doped n and silicon doped p at dark and no apply voltage.The sheet resistance Ïsq at equilibrium is determined from the net ionised doping concentration and the mobility of the majority carriers.The calculator then determines the sheet resistance and the junction depth of the surface diffusion at outdoor temperature..The sheet resistance of silicon with background doped boron has great sheet resistance compared to silicon with background doped phosphorus.
TRANSFERSOMES AS NOVEL DRUG DELIVERY SYSTEM
Authors:   Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Hyderabad., K. Mounika , P. Praneetha ,   Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Hyderabad., N. Srinivas ,   Sarojini Naidu Vanita Pharmacy Maha Vidyalaya, Hyderabad.
Published: May 2023

Transdermal drug delivery appears to be most vital drug delivery system because of its merit over conventional systems. Transferosomes & the fundamental concept of transfersomes were launched by Gregor Cevc in the year 1991. The name means carrying body and is derived from the Latin word transferre, meaning to carry across and the Greek word soma, meaning a body. Novel drug delivery system aims to deliver the drug at a rate directed by need of body during the period of treatment and channel the active entity to the site of action. Transferosome is one of the novel vesicular drug delivery system which consists of phospholipids, surfactant and water for enhanced transdermal delivery. Transferosomes are able to reach intact deeper regions of the skin after topical drug administration while delivering higher concentrations of active substances making them a successful carrier for transdermal applications. These vesicular systems can deliver low as well as high molecular weight compounds. Targeted and controlled release formulations can also be prepared by transferosomes as it can accommodate drug molecules with wide range of solubility. Various strategies can be used to augment the transdermal delivery which includes iontophoresis, electrophoresis, sonophoresis, chemical permeation enhancers, microneedles, & vesicular system (liposomes, niosomes, elastic liposomes such as ethosomes & transfersomes). It exists as an ultra-deformable complex having a hydrated core surrounded by a complex layer of lipid. It penetrates the stratum corneum by either intracellular route or the transcellular route by the generation of osmotic gradient. Advantages of Transferosomes are wide range of solubilities, better penetration, biocompatible and biodegradable etc. Disadvantages of Transferosomes are oxidative degradation, expensive, etc. The transfersomes were formulated by the conventional rotary evaporation sonication method. Transferosomes can be applied in controlled release, transportation of large molecular weight compounds, target delivery to peripheral subcutaneous tissues, transdermal immunization etc.
APPLICATION OF REFRACTIVE INDEX MIXING PRINCIPLES IN BINARY SYSTEMS AT T=298.15, 308.15 AND 318.15K
Authors:   Associate Prof., Department of Chemistry, DBS College, Dehradun, Uttarakhand., Dwivedi Sonu , Kumar Singh Ashih ,   Associate Prof., Department of Chemistry, DBS College, Dehradun, Uttarakhand., Kumar Singh Arun ,   Associate Prof., Department of Chemistry, DBS College, Dehradun, Uttarakhand.
Published: May 2023

Binary liquid mixes of 1-butanol, 1-pentanol, 1-hexanol, and 1-heptanol with hexadecane and heptadecane have had their densities and refractive indices experimentally determined at 298.15, 308.15, and 318.15 K. To determine whether the Lorentz-Lorenz (L-L), Weiner-Heller (W-H), and Gladstone-Dale (G-D) relations for predicting the refractive index of a liquid are valid for the eight binaries over the entire mole fraction range of hexadecane and heptadecane at the three temperatures, a comparative study of these relationships has been conducted. The average percentage deviation has been used to compare different mixing rules. Comparatively speaking, the Weiner and Gladstone-Dale relations perform better than the Lorentz-Lorenz and Heller relations.
ENHANCING THE TRAINING OF MODERN LEADERS IN THE MANAGEMENT SYSTEM OF HIGHER EDUCATION INSTITUTIONS
Authors:   Doctorate Researcher Tashkent State University of Economics Islam Karimov Street 49 100066 Tashkent City, Uzbekistan., Ortiq Suyunovich Temirov
Published: May 2023

There is great interest in present-day leaders in the 21st century because of the widespread belief that the quality of leadership makes a significant difference to universities and student outcomes. There is also increasing recognition that schools require effective leader if they are to provide the best possible management system of higher education institutions. While the need for effective training contemporary leaders is widely acknowledged, there is much less certainty about leadership behaviors that are most likely to produce favorable outcomes. The researcher examines the underpinnings for the field of educational leadership and discuss the evidence of their relative effectiveness in developing successful universities especially during the periods of change. The research paper focuses on the improving of setting standards of training modern administration members in management system of higher education institutions (HEIs) and suggests a standard system for the modern leaders of education institutions according to competence-based approach to reÂ­spond to the current education reform. It is the authors strong believe that training of modern leaders of administrative staff of higher education institutions stimulate social vitality, which itself has an economic impact, drives innovation and productivity growth in global economy.
DEVELOPMENT AND EXPERIMENTAL RESULTS OF OUTCOMES-BASED NURSING PROGRAM
Authors:   School of Nursing of National University of Medical Sciences., P. Odonjil
Published: May 2023

Introduction: Develop the history of nursing education, bachelors degree of professional competence and develop a training curriculum based on the existing nurses professional competency assessment. Research method: For the nurses involved in the survey used randomized descriptive survey methodology, problems faced, nursing knowledge, skills and attitudes. In conducting the survey, we used questionnaires, interviews, observations, documentation and test methods. Nurses knowledge, skills and attitudes are evaluated based on the nurses definition of the 2012 Ministry of Health and a standard questionnaire for Lickert used for quantitative. Result: Nurse training curriculum of seek evaluate ways to continually assess. The results of the survey are based on a comprehensive competency-based curriculum, training quality has been met by organizing training of learners needs. The study shows that there is a need to improve outcome based curriculum and to supplement some content. The average rating of students in the study group (90.06 + -3.34) in the study sample was relatively high (78.38 + -4.85), which contributed to the improvement in the quality of the training, which is an updated version of the comprehensive curriculum and it is possible to introduce similar professional schools. Conclusion: It is important to note that ourinnovative comprehensive competency-based curriculum offers the opportunity to meet the needs of todays curriculum, to facilitate inter-curricular activities, to public health-oriented, student-centered, problem-based, self-taught knowledge and the ability to evaluate the students theoretical and practical abilities.
DEVELOPMENT OF ORGANIZATIONAL SKILLS OF LEADERS IN INCREASING THE EFFICIENCY OF INVESTMENT PROJECTS IN INDUSTRIAL ENTERPRISES
Authors:   Doctorate Researcher Tashkent State University of Economics Islam Karimov Street 49 Tashkent, Uzbekistan., Shahzoda Asatova
Published: May 2023

Confucius said: I hear and I forget, I see and I remember, I do and I understand. The key role in the efficiency of investment projects in industrial enterprises of organizational skills of managers plays vital role, who in ideal should be leaders, enabling organizations efÂ­fectiveness. It is a fact that leadership potential is needed in the specific professional situations, allowing manager to become organizational leader and become successful in managing activities. The sources in leadership theoretical analysis shows the lack of the position power research in organizations. Some ideas of this paper were discussed in the earlier publication. This paper rethinks and specifies some Western sources of diagnostic methods within their interpretations. The paper presÂ­ents the research results on the leadership potential of managers in organizations, as this potential becomes a basic source for a manager building towards being the organizational leader. Nowadays managers have a lack of leadership potential, as it is shown in research. In the paper there are presented the results of the research on the key elements of the leadership potential for managers, moreover, the revealing analysis of the leadership potential structure components of contemporary managers. The results of the research can be used by HR-managers and anyone interested in the issues related to the leadership potential development, effective management and developing the leadership skills in organizational leader.
The Effect of Search, Solve, Create, Share (SSCS) Learning Model on Scientific Reasoning Ability
Authors: Nasir Muhammad Amin , Hayya Adieba Warda
Published: May 2023

The purpose of this study was to determine the effect of the Search, Solve, Create, and Share (SSCS) learning model on students' scientific reasoning abilities in the material of the human movement system. The method used in this research is quasi-experimental. This study used two experimental classes with the SSCS model and a control class with the conventional model. Data were obtained through observation techniques, student response questionnaires, and scientific reasoning ability tests. The results of the study stated that the SSCS model had an effect on students' scientific reasoning abilities. The results of the hypothesis test stated that H0 was rejected and Ha was accepted. This is based on the results of hypothesis testing using the Mann-Whitney test which obtains an Asymp value. Sig. (2-tailed) 0,000 0,05. Through this research, it was revealed that the SSCS learning model had an effect on students' scientific reasoning abilities.
Is Shame Morally Relevant to Ecological Ethics?
Authors: Klimková Andrea
Published: May 2023

In recent years, we have seen a resurgence of the topic of shame in philosophy and moral philosophy. The paper analyses shame as a moral emotion in contemporary moral-philosophical and environmental discourse. Questions are articulated, in which different contexts shame has already been studied and which of them appear to be crucial for ethics and applied ethics? In the article, the author addresses the concept of environmental shame by Sarah E. Fredericks (2021) and considers the questions: is/can shame be ethically relevant for the cultivation of our attitudes in relation to the environment? Is Shame morally relevant to Ecological Ethics? Can the experience of shame affect our moral judgement, decision-making and action regarding the man-nature relationship? Despite the differences in the understanding of shame as a self-conscious emotion or as a social emotion, in the paper the author argues that environmental shame can have an important preventive function as well as a transformative power for the cultivation of our moral beliefs and attitudes.
El personalismo comunitario de Emmanuel Mounier: Características generales y presupuestos fundamentales
Authors: Carrera Randall
Published: May 2023

En esta investigación se realiza una profundización de aspectos fundamentales del pensamiento filosófico del pensador personalista Emmanuel Mounier. Con la finalidad de subsanar algunos equívocos presentes en el estudio de este tema. Se parte de una aclaración conceptual de los términos “tradición filosófica personalista”, “filosofía personalista” y “personalismo comunitario”. Luego se desarrolla una profundización de dos características claves de su propuesta filosófica íntimamente ligadas, tales como la negación a limitarse a un sistema filosófico y la situacionalidad de su reflexión filosófica. Posteriormente se analizan sus presupuestos antropológicos, comunitarios y axiológicos, para finalizar con la elucidación de algunas conclusiones sobre la temática.
Sequence Analysis and Biochemical Characteristics of Two Non-specific
Lipid Transfer Proteins from Tartary Buckwheat Seeds
Authors: Cui Xiaodong , Li Chen , Tian Wenhua , Wang Wenhua , Li Jiao , Wang Zhuanhua
Published: May 2023

Introduction:

Plant non-specific lipid transfer proteins (nsLTPs) play an important role in
plant resistance to various stresses, and show potential applications in agriculture, industrial
manufacturing, and medicine. In addition, as more and more nsLTPs are identified as allergens,
nsLTPs have attracted interest due to their allergenicity. Two nsLTPs from Tartary buckwheat have
been isolated and identified. There is a need to study their biochemical characteristics and
allergenicity.

Objective:

The study aims to investigate the biochemical characteristics of two nsLTPs from Tartary
buckwheat seeds and evaluate their potential allergenicity.

Methods:

Two nsLTPs derived from Tartary buckwheat, namely FtLTP1a and FtLTP1b, were
produced by gene cloning, expression, and purification. Sequence analysis and biochemical
characteristics of the proteins, including lipid binding ability, α-amylase inhibition activity, antifungal
activity, and allergenic activity, were investigated.

Results:

High-purity recombinant FtLTP1a and FtLTP1b were obtained. FtLTP1a and FtLTP1b
exhibited similar lipid binding and antifungal properties. Only FtLTP1b showed weak inhibitory
activity against α-amylase.

Conclusion:

FtLTP1b could specifically bind IgE in the serum allergic to buckwheat and cross-react
with pollen (w6). FtLTP1b is a novel allergenic member of the lipid-transfer protein 1 family found in
Tartary buckwheat.
A Stable Cell Line Co-expressing hTRPV1 and GCaMP6s: A Novel
Cell-based Assay For High-throughput Screening of hTRPV1 Agonists
Authors: Shi Jingjing , Chen Xuejun , Zhang Yi , Shi Tong , Zhang Ruihua , Zhu Siqing , Zong Xingxing , Wang Chen , Li Liqin
Published: May 2023

Background:

Transient receptor potential vanilloid-1 (TRPV1) is a non-selective cation
channel capable of integrating various noxious chemical and physical stimuli. Recently, human
TRPV1 (hTRPV1) has attracted wide attention from researchers because it is closely related to
pain, inflammation, temperature perception, and tumors. Our study was aimed at generating a stable
cell line co-expressing hTRPV1 receptor and GCaMP6s calcium indicator protein and, based
on this, developing high-throughput screening methods for targeting hTRPV1 agonists.

Methods:

The CHO-hTRPV1-GCaMP6s cell line stably expressing hTRPV1 and GCaMP6s was
generated by co-transfection of hTRPV1 and GCaMP6s into Chinese hamster ovary (CHO) cells.
The high-throughput screening methods were developed based on detecting the concentration of
intracellular calcium ions ([Ca2+]i) by using chemically synthesized dyes and genetically encoded
calcium indicator (GECI). Meanwhile, the sensitivity and adaptability of these methods in the
evaluation of capsaicinoids were also compared.

Results:

A stable cell line co-expressing hTRPV1 and GCaMP6s was generated and used to establish
a functional high-throughput screening assay based on the measurement of [Ca2+]i by fluorometric
imaging plate reader (FLIPR). The GECI exhibited a higher sensitivity and applicability
than that of chemically synthesized dyes in detecting the changes in [Ca2+]i induced by capsaicin.
The CHO-hTRPV1-GCaMP6s cell line was further used to detect the dose-dependent relationships
of various hTRPV1 agonists (comparison of EC50 values: capsaicin (39 ± 1.67 nM) < nonivamide
(67 ± 3.05 nM) < piperine (9222 ± 1851 nM)), and this order is consistent with the pharmacological
properties of hTRPV1 activation by these agonists.

Conclusion:

The successful establishment of the CHO-hTRPV1-GCaMP6s cell lines and their
application in high-throughput screening of hTRPV1 agonists.
The Expression and Prognostic Value of Co-stimulatory Molecules in
Clear Cell Renal Cell Carcinoma (CcRcc)
Authors: Wu Chengjiang , Cai Xiaojie , He Chunyan
Published: May 2023

Background:

Renal cell carcinoma (RCC) was one of the most common malignant cancers in the urinary system. Clear cell carcinoma (ccRCC) is the most common pathological type, accounting for approximately 80% of RCC. The lack of accurate and effective prognosis prediction methods has been a weak link in ccRCC treatment. Co-stimulatory molecules played the main role in increasing anti-tumor immune response, which determined the prognosis of patients. Therefore, the main objective of the present study was to explore the prognostic value of Co-stimulatory molecules genes in ccRCC patients.

Methods:

The TCGA database was used to get gene expression and clinical characteristics of patients with ccRCC. A total of 60 Co-stimulatory molecule genes were also obtained from TCGA-ccRCC, including 13 genes of the B7/ CD28 Co-stimulatory molecules family and 47 genes of the TNF family. In the TCGA cohort, the least absolute shrinkage and selection operator (LASSO) Cox regression model was used to generate a multigene signature. R and Perl programming languages were used for data processing and drawing. Real-time PCR was used to verify the expression of differentially expressed genes.

Results:

The study's initial dataset included 539 ccRCC samples and 72 normal samples. The 13 samples have been eliminated. According to FDR<0.05, there were differences in the expression of 55 Co-stimulatory molecule genes in ccRCC and normal tissues. LASSO Cox regression analysis results indicated that 13 risk genes were optimally used to construct a prognostic model of ccRCC. The patients were divided into a high-risk group and a low-risk group. Those in the high-risk group had significantly lower OS (Overall Survival rate) than patients in the low-risk group. Receiver operating characteristic (ROC) curve analysis confirmed the predictive value of the prognosis model of ccRCC (AUC>0.7). There are substantial differences in immune cell infiltration between high and low-risk groups. Functional analysis revealed that immune-related pathways were enriched, and immune status was different between the two risk groups. Real-time PCR results for genes were consistent with TCGA DEGs.

Conclusion:

By stratifying patients with all independent risk factors, the prognostic score model developed in this study may improve the accuracy of prognosis prediction for patients with ccRCC.
Study of work of PVC membranes for engineering waterproofing under increased seismic conditions
Authors: Shalimov V. N. , Tsybenko A. V. , Goglev I. N. , Loginova S. A.
Published: May 2023

Objective. At present, increased requirements are imposed on waterproofing materials used in seismic hazard zones. The aim of the study is to assess the possibility of using LOGICBASE™ polymer membranes in regions of increased seismic activity in the Russian Federation.

Method. The mechanism of operation of polymeric membranes in foundation structures under conditions of constant displacement and friction is considered. Experiments were carried out to determine the coefficient of friction according to the method of state standards on a tensile testing machine MIRK-1000K. Samples of a round shape made of polymeric membranes were studied on a special multiaxial stretching device in accordance with the requirements of state standards.

Result. Multiaxial tensile testing of LOGICBASE™ V-SL polymeric membranes revealed that the maximum tensile strength of the samples was 6948.22 kPa (~ 6.95 MPa), and the elongation of the samples at break was 113.89%. The coefficient of friction in the system "polymer waterproofing material - concrete structure" was determined under conditions of increased seismic activity according to the MSK-64 scale.

Conclusion. According to the studies, it was concluded that PVC membranes for engineering waterproofing can be used in construction areas with seismicity up to 9 points inclusive on the MSK-64 scale.
Lista comentada con clave para la identificación de termitas (Blattodea: Isoptera) asociadas a las zonas forestales de Tabasco, México
Authors: Capetillo-Concepción Eduardo , Perez-De la Cruz Manuel , Valdez-Carrasco Jorge Manuel , De La Cruz-Pérez Aracely , Torres-De La Cruz Magdiel , Magaña Alejandro Miguel Alberto
Published: May 2023

Las termitas son insectos importantes por su participación en la descomposición de la materia orgánica y el reciclaje de los nutrientes en el suelo, sin embargo, algunas especies causan daños en edificaciones, plantaciones forestales y cultivos agrícolas, donde ocasionan pérdidas significativas. El objetivo de este estudio fue realizar un listado comentado con claves de identificación para las especies de termitas presentes en los sistemas agroforestales y relictos de selva en el Estado de Tabasco, México. La recolecta de las termitas se realizó en 20 sitios distribuidos en las principales zonas forestales de Tabasco, México. El muestreo fue dirigido seleccionando 15 transectos de 10x50 m por cada tipo de vegetación. Se identificaron ocho especies de termitas de las cuales Nasutitermes nigriceps (Haldeman, 1854) y N. corniger (Motschulsky, 1855) estuvieron presente en todas las zonas forestales, seguido de Coptotermes testaceus (Linnaeus, 1758) y Heterotermes convexinotatus (Snyder, 1924). Las especies Microcerotermes septentrionalis Light, 1933, Tenuirostritermes briciae (Snyder, 1922), Cahuallitermes intermedius (Snyder, 1922) e Incisitermes snyderi Light, 1933 solo se recolectaron en una localidad. Se reportan como nuevos registros para Tabasco a las especies T. briciae y M. septentrionalis.
Molecular and in Silico Analysis of MEFV Variants in Familial Mediterranean Fever Patients in Southwest Iran
Authors: Noorbakhsh Negar , Zamani Mina , Sedaghat Alireza , Zeighami Jawaher , Foroughi Farangis , Parvas Sahere , Saberi Alihossein , Hamid Mohammad , Ghanavati Roya , Shariati Gholamreza , Galehdari Hamid
Published: May 2023

Familial Mediterranean Fever (FMF) is classified as an autoinflammatory genetic disease inherited by mutations in MEFV. These mutations can affect the dysregulation of inflammatory processes in the human body and lead to fever and pain in the chest and abdomen. Many known missense mutations in MEFV are linked to FMF disease. Mutations in MEFV in most cases are located on the short arm of chromosome 16 and can impair the function of the pyrin protein. In this research, we aimed to examine the entire exons of MEFV for 13 cases (8 females and 5 males) with FMF diagnosis from Southwest Iran. Hence, we amplified and sequenced the exons of MEFV and then, in-silico analysis of detected changes was applied to estimate the probability of pathogenicity for the identified variants. Finally, we found five single nucleotide substitutions, including M694V (c.2080A>G), R202Q (c.605G>A), E447G (c.1430A>G), E148Q (c.442G>C), and V726A (c.2177T>C), in the under-represented patients. The most frequent mutations in our study were R202Q (38.46%) within exon 2 and M694V (30.7%) within exon 10. Other mutations accounted for a further 23% of the alleles, including E477G (7.6%), E148Q (7.6%), and V726A (7.6%). According to the in-silico analyses, including variation pathogenicity, protein structure, and allele frequency assessments, we concluded that all these variants could be considered in FMF molecular profiling in southwest Iran.
Facilitators and Barriers to the Sustainability of eHealth Solutions in Low- and Middle-Income Countries: Descriptive Exploratory Study
Authors: Mamuye Adane , Nigatu Araya Mesfin , Chanyalew Moges Asressie , Amor Lamia Ben , Loukil Sihem , Moyo Chris , Quarshie Samuel , Antypas Konstantinos , Tilahun Binyam
Published: May 2023

Background

Despite the widely anticipated benefits of eHealth technologies in enhancing health care service delivery, the sustainable usage of eHealth in transitional countries remains low. There is limited evidence supporting the low sustainable adoption of eHealth in low- and middle-income countries.

Objective

The aim of this study was to explore the facilitators and barriers to the sustainable use of eHealth solutions in low- and middle-income nations.

Methods

A qualitative descriptive exploratory study was conducted in 4 African nations from September to December 2021. A semistructured interview guide was used to collect the data. Data were audio-recorded and transcribed from the local to the English language verbatim, and the audio data were transcribed. On the basis of the information gathered, we assigned codes to the data, searched for conceptual patterns, and created emerging themes. Data were analyzed thematically using OpenCode software.

Results

A total of 49 key informant interviews (10 from Tunisia, 15 from Ethiopia, 13 from Ghana, and 11 from Malawi) were conducted. About 40.8% (20/49) of the study participants were between the ages of 26 and 35 years; 73.5% (36/49) of them were male participants; and 71.4% (35/49) of them had a master’s degree or higher in their educational background. Additionally, the study participants' work experience ranged from 2 to 35 years. Based on the data we gathered, we identified 5 themes: organizational, technology and technological infrastructure, human factors, economy or funding, and policy and regulations.

Conclusions

This study explores potential facilitators and barriers to long-term eHealth solution implementation. Addressing barriers early in the implementation process can aid in the development of eHealth solutions that will better fulfill the demands of end users. Therefore, focusing on potential challenges would enhance the sustainability of eHealth solutions in low- and middle-income countries.
Mengkaji Publikasi Dosen Menggunakan Analisis Bibliometrik
Authors: Mubarok Aly , Istiana Purwani
Published: May 2023

INTISARI

Pertumbuhan publikasi menjadi perhatian sebuah institusi pendidikan tinggi. Capaian jumlah publikasi menjadi salah satu indikator kinerja institusi pendidikan tinggi. Tujuan penelitian ini adalah mendekripsikan profil dokumen dosen Fakultas Farmasi yang terindeks pada database bereputasi Internasional (Scopus). Deskripsi profil dokumen tersebut meliputi, sebaran dokumen berdasarkan tahun, jenis tipe dokumen, penulis/dosen paling produktif, dokumen berdasarkan sumber, dokumen yang paling banyak disitir, dan tren topik riset dosen. Data dikumpulkan berdasarkan Scopus ID dosen. Analisis bibliometrik digunakan pada penelitian ini terhadap 989 dokumen. Aplikasi Vosviewer digunakan untuk memvisualiasikan kata kunci. Hasil penelitian menunjukkan bahwa pada rentang tahun 2012-2021, dokumen terbanyak terjadi pada tahun 2020 yakni mencapai 217 dokumen. Tipe dokumen terbanyak adalah artikel jurnal mencapai 88, 465. Penulis/dosen paling produktif dengan 252 dokumen adalah Rohman, Abdul. Karya dosen paling banyak terdapat pada sumber Journal of applied Pharmaceutical Science. Artikel yang berjudul  Paper-Based Microfluidic Devices: Emerging Themes and Applications merupakan artikel yang paling banyak disitir dan berdasarkan hasil visualisasi kata kunci menggunakan aplikasi Vosviewer diketahui kata kunci Ftir Spectroscopy, Indonesia dan Chemometrics merupakan kata kunci yang dominan muncul pada dokumen rentang tahun 2012-2021.
Prediction of Tenderness, Juiciness, and Flavor Profile of 2 Beef Muscles with Different Aging Times Using Rapid Evaporative Ionization Mass Spectrometry (REIMS)
Authors: Hernandez-Sintharakao Michael J. , Sarchet Chandler J. , Prenni Jessica E. , Woerner Dale R. , Zhai Chaoyu , Nair Mahesh N.
Published: May 2023

Rapid evaporative ionization mass spectrometry (REIMS) is a novel technique that provides rapid chemical information on biological tissues and has the potential to predict beef quality attributes in real time. This study aims to assess the ability of analysis by REIMS coupled with chemometric modeling to predict the quality attributes of wet-aged beef at the grading time. USDA Select and upper two-thirds Choice (n=42, N=84) striploins (longissimus lumborum [LL]) and tenderloins (psoas major [PM]) were collected 36 h postmortem from a commercial beef abattoir. The LL and PM were cut into portions and aged for 3, 14, and 28 d. Aged samples were analyzed for slice shear force,Warner-Bratzler shear force (WBS), and trained sensory panels (tenderness, juiciness, and flavor attributes), and results were used to categorize both LL and PM into binary classes. Additionally, slivers of the longissimus dorsi muscle between the 12th and 13th rib were collected during grading (36 h postmortem) and analyzed using REIMS. The REIMS data were used to build predictive models for tenderness, juiciness, and flavor classes for the 3 aging periods and 2 muscles. Prediction accuracies of all models were higher than classifying the samples by chance (P<0.05), except WBS of 3 d aging model (P>0.05). However, model accuracies were not too high, which could be due to overlaps between classes, small sample sizes, and unbalanced data, which could negatively affect predictive models. Results demonstrated that the chemical finger-prints obtained with REIMS could potentially sort carcasses by flavor, juiciness, and tenderness in real time. However, the full realization of this approach will require an increased sample size and the development of a sampling method that allows improved separation between sensory classes.
5-Hydroxytryptamine receptors in GtoPdb v.2023.1
Authors: Andrade Rodrigo , Barnes Nicholas M. , Baxter Gordon , Bockaert Joel , Branchek Theresa , Butler Amy , Cohen Marlene L. , Dumuis Aline , Eglen Richard M. , Göthert Manfred , Hamblin Mark , Hamon Michel , Hartig Paul R. , Hen René , Hensler Julie , Herrick-Davis Katharine , Hills Rebecca , Hoyer Daniel , Humphrey Patrick P. A. , Latté Klaus Peter , Maroteaux Luc , Martin Graeme R. , Middlemiss Derek N. , Mylecharane Ewan , Neumaier John , Peroutka Stephen J. , Peters John A. , Roth Bryan , Saxena Pramod R. , Sharp Trevor , Sleight Andrew , Villalon Carlos M. , Yocca Frank
Published: May 2023

5-HT receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on 5-HT receptors [198] and subsequently revised [180]) are, with the exception of the ionotropic 5-HT3 class, GPCRs where the endogenous agonist is 5-hydroxytryptamine. The diversity of metabotropic 5-HT receptors is increased by alternative splicing that produces isoforms of the 5-HT2A (non-functional), 5-HT2C (non-functional), 5-HT4, 5-HT6 (non-functional) and 5-HT7 receptors. Unique amongst the GPCRs, RNA editing produces 5-HT2C receptor isoforms that differ in function, such as efficiency and specificity of coupling to Gq/11 and also pharmacology [40, 491]. Most 5-HT receptors (except 5-ht1e and 5-ht5b) play specific roles mediating functional responses in different tissues (reviewed by [471, 387]).
Calcium-sensing receptor in GtoPdb v.2023.1
Authors: Bikle Daniel , Bräuner-Osborne Hans , Brown Edward M. , Chang Wenhan , Conigrave Arthur , Hannan Fadil , Leach Katie , Riccardi Daniela , Shoback Dolores , Ward Donald T. , Yarova Polina
Published: May 2023

The calcium-sensing receptor (CaS, provisional nomenclature as recommended by NC-IUPHAR [47] and subsequently updated [77]) responds to multiple endogenous ligands, including extracellular calcium and other divalent/trivalent cations, polyamines and polycationic peptides, L-amino acids (particularly L-Trp and L-Phe), glutathione and various peptide analogues, ionic strength and extracellular pH (reviewed in [78]). While divalent/trivalent cations, polyamines and polycations are CaS receptor agonists [14, 110], L-amino acids, glutamyl peptides, ionic strength and pH are allosteric modulators of agonist function [36, 47, 61, 108, 109]. Indeed, L-amino acids have been identified as "co-agonists", with both concomitant calcium and L-amino acid binding required for full receptor activation [149, 54]. The sensitivity of the CaS receptor to primary agonists is increased by elevated extracellular pH [18] or decreased extracellular ionic strength [109] while sensitivity is decreased by pathophysiological phosphate concentrations [20]. This receptor bears no sequence or structural relation to the plant calcium receptor, also called CaS.
Class C Orphans in GtoPdb v.2023.1
Authors: Bikle Daniel , Bräuner-Osborne Hans , Brown Edward M. , Conigrave Arthur , Shoback Dolores
Published: May 2023

This set contains class C 'orphan' G protein coupled receptors where the endogenous ligand(s) is not known.
Free fatty acid receptors in GtoPdb v.2023.1
Authors: Briscoe Celia , Brown Andrew , Holliday Nick , Jenkinson Stephen , Milligan Graeme , Monaghan Amy E. , Stoddart Leigh
Published: May 2023

Free fatty acid receptors (FFA, nomenclature as agreed by the NC-IUPHAR Subcommittee on free fatty acid receptors [116, 27]) are activated by free fatty acids. Long-chain saturated and unsaturated fatty acids (including C14.0 (myristic acid), C16:0 (palmitic acid), C18:1 (oleic acid), C18:2 (linoleic acid), C18:3, (α-linolenic acid), C20:4 (arachidonic acid), C20:5,n-3 (EPA) and C22:6,n-3 (docosahexaenoic acid)) activate FFA1 [9, 54, 64] and FFA4 receptors [45, 52, 94], while short chain fatty acids (C2 (acetic acid), C3 (propanoic acid), C4 (butyric acid) and C5 (pentanoic acid)) activate FFA2 [10, 66, 90] and FFA3 [10, 66] receptors. The crystal structure for agonist bound FFA1 has been described [113].
Glycoprotein hormone receptors in GtoPdb v.2023.1
Authors: Costagliola Sabine , Dias James A. , Gershengorn Marvin , Pawson Adam J , Segaloff Deborah L. , Themmen Axel P.N. , Vassart Gilbert
Published: May 2023

Glycoprotein hormone receptors (provisional nomenclature [47]) are activated by a non-covalent heterodimeric glycoprotein made up of a common α chain (glycoprotein hormone common alpha subunit CGA, P01215), with a unique β chain that confers the biological specificity to FSH, LH, hCG or TSH. There is binding cross-reactivity across the endogenous agonists for each of the glycoprotein hormone receptors. The deglycosylated hormones appear to exhibit reduced efficacy at these receptors [122, 31].
Melanin-concentrating hormone receptors in GtoPdb v.2023.1
Authors: Audinot Valérie , Boutin Jean A. , Lakaye Bernard , Nahon Jean-Louis , Saito Yumito
Published: May 2023

Melanin-concentrating hormone (MCH) receptors (provisional nomenclature as recommended by NC-IUPHAR [32]) are activated by an endogenous nonadecameric cyclic peptide identical in humans and rats (DFDMLRCMLGRVYRPCWQV; mammalian MCH) generated from a precursor (PMCH, P20382), which also produces neuropeptide EI and neuropeptide GE.
The impacts of school on English learners’ motivation in Indonesian Islamic schools
Authors: Farid Achmad , Adara Reza Anggriyashati , Ashar Salim
Published: May 2023

Among the teaching practitioners in Indonesia, there is a general belief that some learners of English in some Indonesian pesantren (Islamic boarding schools) have a negative view on English, which consequently affects their motivation. However, it remains unclear what has affected the trend. The current study investigates this issue in three pesantren schools in Indonesia affiliated with different Islamic groups. Using the L2 Motivational Self System (L2MSS) model proposed by Dörnyei (2009) as an analytical lens, a survey instrument was designed to describe and compare students’ motivation to learn English (n = 376). A multivariate analysis of variance (MANOVA) was run to describe and compare the students’ motivation, and a stepwise multiple regression analysis was performed to discover which motivational factors made the most significant contribution to motivation by predicting reported learning effort in English.  In addition, a thorough document analysis was performed to obtain background information regarding the teaching of English in the three institutions. It was found that institutional factors do play a role in influencing the learners’ motivation, in that in the most religiously conservative context, the school policy does shape the learners’ ideal L2 self. As the learners’ ideal L2 self was weak, it leads to weak motivational power as well. The paper concludes by emphasizing the crucial role of educational contexts in shaping students’ ideal selves and in providing favourable learning experience, which are key elements in motivating learners to learn English.
“Publish or no degree”: Cultivating a scholarly writing Group for Indonesian Master’s students of English education
Authors: Fithriani Rahmah , Ichsanda Rahman Hz Benni , Seroja br Ginting Rita
Published: May 2023

In line with the increasing institutionalization of scholarly publication as a graduation requirement for graduate students around the world, the use of a community of writing practice to support students navigate their publication endeavour has begun to receive attention from academic supervisors and graduate researchers. Despite the burgeoning interest in this topic, there has been little empirical evidence on master’s students’ experiences and perspectives of working within such writing groups at an Indonesian university. This phenomenological case study intends to fill this lacuna by elaborating on the process of a writing group's establishment and development for master's students of English education and exploring their perceptions of participating in such a community of practice (COP). Findings indicate that the writing group served as a flexible and participatory COP that produced critical and enduring alterations in identity as scholarly writers amongst participants. Specifically, their perceived transition into academic writers involves three aspects: knowledge of the values of scholarly publication, construction of a scholarly identity, and demystification of the publishing endeavour. This study's findings can be utilized to inform other master's and doctorate programs, as well as academic professionals seeking interventions to assist their students' productive writing.
Weighing research competencies of department of English language education graduates at UIN Ar-Raniry Banda Aceh
Authors: Dahliana Syarifah , Akmal Saiful , Phonna Rizka Malda
Published: May 2023

The purpose of this study is to scrutinize participants’ research competency, source of research competency, and problems related to the research conduct. Nine graduates of the Department of English Language Education were purposefully selected; three of them completed their theses in one semester, three others finished in two semesters, and one other finalized in three semesters. In this qualitative study, semi-structured interviews were used. The findings revealed that graduates with one-semester thesis completion rates have stronger research proficiency than other groups. They have a higher motivational value component, a higher methodology-reflective component, and a higher operational activity component of research competency. Meanwhile, the emotional-volitional component of research competency remains equal for each group of participants. Furthermore, graduates acquired research competency through coursework, research conduct, and self-study. In terms of problems with research conduct, the data disclosed that graduates frequently struggled with self-motivation, supervisors, time/class schedule, knowledge of prior studies, data analysis, and  participants selection.
DAWĀ AL-QULŪB MANUSCRIPT BY MUHAMMAD KHATIB LANGGIEN (TEXT EDITING AND STUDY OF CENTRAL IDEA)
Authors: Khairatunnisak  , Hermansyah  , Istiqomatunnisak
Published: May 2023

One of the 19th-century manuscripts written in Malay Arabic-Jawi that comprises the sufi knowledge is the Dawā’ul Qulūb manuscript. The primary concepts in the manuscript and the text modifications are the subjects of this study. Given that the manuscript contains multiple variant texts, the research strategy employs the philological method in conjunction with the foundational method approach. The two manuscripts used in this study, both of which were collections of the Aceh State Museum, were found after a search of the manuscripts turned up as many as four manuscript texts. The first manuscript, with inventory number 07.1430, was used as the basic manuscript, and the second, with inventory number 07.812, was used as a comparative text. Due of its higher quality and closer (older) age to the autograph text, text 07.1430 was picked. Nevertheless, moral illness and how to prevent it are the focus of this manuscript's main concept. According to the findings of this study, the Dawā’ul Qulūb manuscript, which contains Islamic teachings on sufism, contains two parts: first; corrected text with a critical edition, and second; knowing clearly and in detail the contents of the Dawā’ul Qulūb manuscript which contains Islamic teachings on the Sufism knowledge. Some of the sub-chapters contained in the manuscript include: immoral parts of body, immoral hearts, and obedient in the heart.
PERJANJIAN KERJASAMA ANTARA PIHAK PENJUAL DENGAN PROVIDER SHOPEE MENURUT PERSPEKTIF IJÃRAH BI AL-MANFA’AH
Authors: Nurfitri Yumni Syawalianita , Mubarrak Husni , Achyar Gamal
Published: May 2023

Shopee sebagai aplikasi yang bergerak dibidang jual beli online dan dapat diakses secara mudah dengan menggunakan smartphone. Shopee akan menyediakan dan menawarkan berbagai macam produk-produk fashion hingga produk untuk kebutuhan sehari-hari. Praktik sewa-menyewa antara penjual dengan Shopee terjadi secara otomatis karena hanya sebatas pembukaan toko tanpa adanya biaya sewa, sedangkan syarat ijârah adalah adanya upah/ujrah (harga sewa) yaitu nilai harta yang dikeluarkan sebagai pengganti manfaat dari barang. Pada kenyataannya membuka toko dalam merketplace online Shopee tidaklah gratis, karena para penjual yang menjual barang dagangannya harus bersedia mengikuti segala ketentuan yang dibuat oleh pihak Shopee, yaitu penahanan uang selama beberapa waktu sampai adanya konfirmasi dari pembeli. Pertanyaan penelitian pada skripsi ini adalah Bagaimana klausula Perjanjian yang Disepakati oleh Pihak penjual sebagai Online Shop dengan Shopee. Apakah perjanjian kerjasama antara pihak penjual dengan Shopee telah sesuai dengan perspektif akad ijârah bi al-manfa’ah. Adapun jenis penelitian yang digunakan dalam skripsi ini adalah deskriptif analisis dan pendekatan kualitatif. Teknik yang digunakan dengan cara wawancara dan observasi. Hasil penelitian menunjukkan bahwa perjanjian kerjasama antara penjual dan Shopee dibuat secara sepihak oleh Shopee. Penjual dan pihak Shopee melakukan akad sewa menyewa ijârah. Karena terdapat upah atau imbalan melalui penahanan atau peminjaman uang di dalam rekening bersama ataupun Shopee Pay. Pihak Shopee juga tidak bisa mengakui bahwa transaksi dalam Shopee sepenuhnya gratis. Karena Shopee meminjam uang penjualan yang ditahan selama beberapa waktu untuk memberikan subsidi gratis ongkos kirim dan promo menarik lainnya untuk menarik minat pengguna Shopee.