bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic and Environmental Influence on the Human Functional Connectome
Authors: Reineberg Andrew E , Hatoum Alexander S , Hewitt John K , Banich Marie T , Friedman Naomi P
Published: September 2019

Detailed mapping of genetic and environmental influences on the functional connectome is a crucial step toward developing intermediate phenotypes between genes and clinical diagnoses or cognitive abilities. We analyzed resting-state functional magnetic resonance imaging data from two adult twin samples (Nos = 446 and 371) to quantify genetic and environmental influence on all pairwise functional connections between 264 brain regions (~35 000 functional connections). Nonshared environmental influence was high across the whole connectome. Approximately 14–22% of connections had nominally significant genetic influence in each sample, 4.6% were significant in both samples, and 1–2% had heritability estimates greater than 30%. Evidence of shared environmental influence was weak. Genetic influences on connections were distinct from genetic influences on a global summary measure of the connectome, network-based estimates of connectivity, and movement during the resting-state scan, as revealed by a novel connectome-wide bivariate genetic modeling procedure. The brain’s genetic organization is diverse and not as one would expect based solely on structure evident in nongenetically informative data or lower resolution data. As follow-up, we make novel classifications of functional connections and examine highly localized connections with particularly strong genetic influence. This high-resolution genetic taxonomy of brain connectivity will be useful in understanding genetic influences on brain disorders.
The Connectivity Fingerprint of the Fusiform Gyrus Captures the Risk of Developing Autism in Infants with Tuberous Sclerosis Complex
Authors: Scherrer Benoit , Prohl Anna K , Taquet Maxime , Kapur Kush , Peters Jurriaan M , Tomas-Fernandez Xavier , Davis Peter E , M Bebin Elizabeth , Krueger Darcy A , Northrup Hope , Y Wu Joyce , Sahin Mustafa , Warfield Simon K
Published: September 2019

Tuberous sclerosis complex (TSC) is a rare genetic disorder characterized by benign tumors throughout the body; it is generally diagnosed early in life and has a high prevalence of autism spectrum disorder (ASD), making it uniquely valuable in studying the early development of autism, before neuropsychiatric symptoms become apparent. One well-documented deficit in ASD is an impairment in face processing. In this work, we assessed whether anatomical connectivity patterns of the fusiform gyrus, a central structure in face processing, capture the risk of developing autism early in life. We longitudinally imaged TSC patients at 1, 2, and 3 years of age with diffusion compartment imaging. We evaluated whether the anatomical connectivity fingerprint of the fusiform gyrus was associated with the risk of developing autism measured by the Autism Observation Scale for Infants (AOSI). Our findings suggest that the fusiform gyrus connectivity captures the risk of developing autism as early as 1 year of age and provides evidence that abnormal fusiform gyrus connectivity increases with age. Moreover, the identified connections that best capture the risk of developing autism involved the fusiform gyrus and limbic and paralimbic regions that were consistent with the ASD phenotype, involving an increased number of left-lateralized structures with increasing age.
microRNA Deficiency in VIP+ Interneurons Leads to Cortical Circuit Dysfunction
Authors: Qiu Fang , Mao Xingfeng , Liu Penglai , Wu Jinyun , Zhang Yuan , Sun Daijing , Zhu Yueyan , Gong Ling , Shao Mengmeng , Fan Keyang , Chen Junjie , Lu Jiangteng , Jiang Yan , Zhang Yubin , Curia Giulia , Li Anan , He Miao
Published: September 2019

Genetically distinct GABAergic interneuron subtypes play diverse roles in cortical circuits. Previous studies revealed that microRNAs (miRNAs) are differentially expressed in cortical interneuron subtypes, and are essential for the normal migration, maturation, and survival of medial ganglionic eminence-derived interneuron subtypes. How miRNAs function in vasoactive intestinal peptide expressing (VIP+) interneurons derived from the caudal ganglionic eminence remains elusive. Here, we conditionally removed Dicer in postmitotic VIP+ interneurons to block miRNA biogenesis. We found that the intrinsic and synaptic properties of VIP+ interneurons and pyramidal neurons were concordantly affected prior to a progressive loss of VIP+ interneurons. In vivo recording further revealed elevated cortical local field potential power. Mutant mice had a shorter life span but exhibited better spatial working memory and motor coordination. Our results demonstrate that miRNAs are indispensable for the function and survival of VIP+ interneurons, and highlight a key role of VIP+ interneurons in cortical circuits.
Specifying a New Requirement Model for Secure Adaptive Systems
Authors: Alyari Robab , Karimpour Jaber , Izadkhah Habib
Published: September 2019

Security is a growing concern in developing software systems. It is important to face unknown threats in order to make the system continue operating properly. Threats are vague and attack methods change frequently. Coping with such changes is a major feature of an adaptive software. Therefore, designing an adaptive secure software is an appropriate solution to address software security challenges. Through estimation of maximum amount of system assets security, one can determine whether the system is protecting the assets or not; if not, reconfiguration can be employed. This paper proposes a new requirement model for secure adaptive systems using fuzzy, goal modeling and Description Logic concepts. The model contains three phases of modeling security aspects of the system, identifying formalizations and relations between the requirements and monitoring and adapting, when needed. To illustrate the relations between the requirements, goal modeling is used in the first phase and fuzzy Description Logic in the second phase. For the third phase, four algorithms are proposed to monitor and determine whether reconfiguration is needed or not. Theorems are given to prove concept satisfaction of the requirements. Furthermore, examples and case studies are discussed to evaluate and show applicability of the proposed model.
Prevalence of venous thromboembolism in admissions and readmissions with and without syncope: a nationwide cohort study
Authors: Kadri Amer N , Zawit Misam , Al-Adham Raed , Hader Ismail , Nusairat Leen , Almahmoud Mohamed F , Senussi Mourad , Altibi Ahmed , Barakat Amr , Hernandez Adrian V , Masri Ahmad
Published: September 2019

Aims

The Pulmonary Embolism in Syncope Italian Trial reported 17.3% prevalence of pulmonary embolism (PE) in patients admitted with syncope. We investigated the prevalence of venous thromboembolism [VTE, including PE and deep vein thrombosis (DVT)] in syncope vs. non-syncope admissions and readmissions, and if syncope is an independent predictor of VTE.

Methods and results

We conducted an observational study of index admissions of the 2013–14 Nationwide Readmission Database. We excluded patients <18 years, December discharges, died during hospitalization, hospital transfers, and missing length of stay. Encounters were stratified by the presence or absence of DVT/PE and syncope diagnoses. Multivariable logistic regression analysis was used to evaluate the association between syncope and VTE. There were 38 655 570 admissions, of whom 285 511 had syncope. In the overall cohort, syncope occurred in 1.6% of VTE and 1.8% in non-VTE admissions. In a multivariable model, syncope was associated with a lower prevalence of VTE [odds ratio (OR) 0.76, 95% confidence interval (CI) 0.75–0.78; P < 0.001]. In index syncope vs. non-syncope admissions, the prevalence of DVT, PE, and VTE were 0.4 ± 0.06% vs. 1.3 ± 0.12%, 0.2 ± 0.04% vs. 1.2 ± 0.11%, and 0.5 ± 0.07% vs. 2.1 ± 0.14% (all P < 0.001), respectively. At 30 days, the prevalence of DVT, PE, and VTE in syncope vs. non-syncope were 2.2 ± 0.14% vs. 2.1 ± 0.14% (P = 0.38), 1.4 ± 0.12% vs. 1.2 ± 0.11% (P = 0.01), and 2.6 ± 0.17% vs. 3.0 ± 0.17% (P = 0.99), respectively.

Conclusion

Syncope admissions were associated with a lower prevalence of VTE as compared to non-syncope admissions. Syncope should not trigger an automatic PE workup, rather, should be put into context of patient presentation.
Farmers’ heterogeneous motives, voluntary vaccination and disease spread: an agent-based model
Authors: Sok Jaap , Fischer Egil A J
Published: September 2019

Animal health authorities responsible for effective voluntary livestock disease control need to consider the dynamic interplay between farmers’ collective behaviour and disease epidemiology. We present an agent-based model to simulate vaccination scheme designs that differ in expected adverse vaccine effects, communication strategies and subsidy levels. Specific scheme designs improve the vaccine uptake by farmers at the start of a livestock disease epidemic compared with a base scheme of minimal communication and subsidy. The results suggest that motivational mechanisms activated by a well-designed risk communication strategy are equally or more effective in increasing vaccination uptake than providing more financial compensation.
Limited reproducibility of MUCH and WUCH: evidence from the ELSA study
Authors: Mancia Giuseppe , Facchetti Rita , Cuspidi Cesare , Bombelli Michele , Corrao Giovanni , Grassi Guido
Published: September 2019

Aims

To evaluate the long-term reproducibility of masked (MUCH) and white-coat uncontrolled hypertension (WUCH), an information crucial for determining the long-term prognostic impact of these conditions.

Methods and results

Reproducibility of MUCH and WUCH was assessed in 1664 hypertensive patients recruited for the European Lacidipine Study on Atherosclerosis and treated with atenolol or lacidipine (±additional drugs) during a 4-year period. Office and 24 h blood pressure (BP) was measured at baseline and every year during treatment, allowing repeated classification of either condition. After 1 year of treatment 21.1% and 17.8% of the patients were classified as MUCH and WUCH, respectively. For both conditions the prevalence was similar in the following years, although with a large change in patients composition because only about 1/3 of patients classified as MUCH or WUCH at one set of office and ambulatory BP measurements maintained the same classification at a subsequent set of measurements. In only 4.5% and 6.2% MUCH and WUCH persisted throughout the treatment period. MUCH and WUCH reproducibility was worse than that of patients showing control or lack of control of both office and ambulatory BP, i.e. controlled and uncontrolled hypertension, respectively.

Conclusion

Both MUCH and WUCH display poor reproducibility over time. This should be taken into account in studies assessing the long-term prognostic value of these conditions based on only one set of BP measurements.
Altered fibrin clot properties and fibrinolysis in patients with atrial fibrillation: practical implications
Authors: Undas Anetta
Published: September 2019

Compelling evidence indicates that a hypercoagulable state occurs in patients with atrial fibrillation (AF) including those in sinus rhythm following paroxysmal and persistent AF. Activation of blood coagulation in AF reflects heightened thrombin generation with the subsequent increased formation of fibrin as evidenced by elevated soluble fibrin monomers and D-dimer. Formation of denser fibrin meshworks, relatively resistant to plasmin-mediated lysis has been demonstrated in patients with AF. The presence of stroke risk factors in AF, such as diabetes, heart failure, hypertension, previous myocardial infarction, or stroke, advanced age have been shown to be linked to the prothrombotic clot characteristics, including reduced clot permeability and lysability. Importantly, biomarkers, including cardiac troponins and N-terminal pro-brain natriuretic peptide, are associated with thrombin generation and fibrin-related markers in AF patients. Recently, increased fibrin clot density (low clot permeability measured in plasma-based assays) and impaired fibrinolysis measured off anticoagulation have been demonstrated to predict ischaemic cerebrovascular events in patients with AF receiving vitamin K antagonists and those on rivaroxaban. The current review summarizes evidence for a role of altered fibrin clot properties and hypofibrinolysis in AF and their prognostic value in terms of adverse events.
Successional trophic complexity and biogeographical structure of eukaryotic communities in waterworks' rapid sand filters
Authors: Bugge Harder Christoffer , Nyrop Albers Christian , Rosendahl Søren , Aamand Jens , Ellegaard-Jensen Lea , Ekelund Flemming
Published: September 2019

As groundwater-fed waterworks clean their raw inlet water with sand filters, a variety of pro- and eukaryotic microbial communities develop on these filters. While several studies have targeted the prokaryotic sand filter communities, little is known about the eukaryotic communities, despite the obvious need for knowledge of microorganisms that get in contact with human drinking water. With a new general eukaryotic primer set (18S, V1-V3 region), we performed FLX-454 sequencing of material from 21 waterworks' sand filters varying in age (3–40 years) and geographical location on a 250 km east–west axis in Denmark, and put the data in context of their previously published prokaryotic communities. We find that filters vary highly in trophic complexity depending on age, from simple systems with bacteria and protozoa (3–6 years) to complex, mature systems with nematodes, rotifers and turbellarians as apex predators (40 years). Unlike the bacterial communities, the eukaryotic communities display a clear distance–decay relationship that predominates over environmental variations, indicating that the underlying aquifers feeding the filters harbor distinct eukaryotic communities with limited dispersal in between. Our findings have implications for waterworks' filter management, and offer a window down to the largely unexplored eukaryotic microbiology of groundwater aquifers.
Probing upper mantle electrical conductivity with daily magnetic variations using global-to-local transfer functions
Authors: Guzavina M , Grayver A , Kuvshinov A
Published: September 2019

We present new transfer functions (TFs) that can handle external electromagnetic (EM) sources of complex geometry. These TFs relate global expansion coefficients describing the source with a locally measured EM field. In this study, the new TFs concept was applied to the daily magnetic variations measured at the ground. The parameterisation of the source in terms of spherical harmonics was adopted. We used nearly 20 years of data from 125 mid-latitude observatories and explored how the results are affected by (I) solar activity conditions, (II) the choice of the prior conductivity model used for the source coefficient estimation, and (III) the presence of ocean tidal magnetic signals. We found that choosing magnetically quiet periods is beneficial due to simpler source morphology, and the choice of prior conductivity model may significantly affect the source coefficients and TFs at short periods. We further observed significant contributions by ocean tidal magnetic signals at coastal and island observatories and corrected for them. Finally, the estimated TFs were inverted for the mantle conductivity at several locations representing different geological settings.
Cell-Mediated Immune Responses After Influenza Vaccination of Solid Organ Transplant Recipients: Secondary Outcomes Analyses of a Randomized Controlled Trial
Authors: L’huillier Arnaud G , Ferreira Victor H , Hirzel Cedric , Natori Yoichiro , Slomovic Jaclyn , Ku Terrance , Hoschler Katja , Ierullo Matthew , Selzner Nazia , Schiff Jeffrey , Singer Lianne G , Humar Atul , Kumar Deepali
Published: September 2019

Background

Despite annual immunization, solid organ transplant (SOT) patients remain at increased risk for severe influenza infection because of suboptimal vaccine immunogenicity. We aimed to compare the CD4+ and CD8+ T-cell responses of the high-dose (HD) and the standard-dose (SD) trivalent inactivated vaccine.

Methods

We collected peripheral blood mononuclear cells pre- and postimmunization from 60 patients enrolled in a randomized trial of HD versus SD vaccine (30 HD; 30 SD) during the 2016–2017 influenza season.

Results

The HD vaccine elicited significantly greater monofunctional and polyfunctional CD4+ and CD8+ T-cell responses against influenza A/H1N1, A/H3N2, and B. For example, median vaccine-elicited influenza-specific polyfunctional CD4+ T cells were higher in recipients of the HD than SD vaccine after stimulation with influenza A/H1N1 (1193 vs 0 per 106 CD4+ T cells; P = .003), A/H3N2 (1154 vs 51; P = .008), and B (1102 vs 0; P = .001). Likewise, vaccine-elicited influenza-specific polyfunctional CD8+ T cells were higher in recipients of the HD than SD vaccine after stimulation with influenza B (367 vs 0; P = .002).

Conclusions

Our study provides novel evidence that HD vaccine elicits greater cellular responses compared with the SD vaccine in SOT recipients, which provides support to preferentially consider use of HD vaccination in the SOT setting.
Composition of gut microbiota of children and adolescents with perinatal HIV infection taking antiretroviral therapy in Zimbabwe
Authors: Flygel Trym T , Sovershaeva Evgeniya , Classen-Weitz Shantelle , Hjerde Erik , Mwaikono Kilaza S , Odland Jon Ø , Ferrand Rashida A , Mchugh Grace , Gutteberg Tore J , Nicol Mark P , Cavanagh Jorunn P , Flægstad Trond ,   Breathe Study Team
Published: September 2019

Background

HIV infection causes impairment of the gastrointestinal barrier, with substantial depletion of CD4+ T-cells in the gut. Antiretroviral therapy (ART) restores CD4+ counts and may have beneficial effects on gut microbiota in adults. Little is known about effect of long-term ART on gut microbiome in HIV infected children. We investigated composition of gut microbiota in HIV infected and uninfected children and assessed associations between gut microbiota and patient characteristics.

Methods

In a cross-sectional study, rectal swabs were collected from 177 HIV infected and 103 HIV uninfected controls. Gut microbial composition was explored using 16S rRNA sequencing (Illumina Miseq).

Results

HIV infected children had significantly lower alpha-diversity and higher beta-diversity compared to HIV uninfected. No association was observed between microbiome diversity and CD4+ T-cell count, HIV viral load or HIV-associated chronic lung disease. We found enriched levels of Corynebacterium (p<0.01), Finegoldia (p<0.01) and Anaerococcus (p<0.01) in HIV infected, and enrichment of Enterobacteriaceae (p=0.02) in participants with low CD4+ counts (<400 cells/mm3). Prolonged ART-treatment (≥10 years) was significantly associated with a richer gut microbiota by alpha diversity.

Conclusion

HIV infected children have altered gut microbiota. Prolonged ART may restore the richness of the microbiota closer to that of HIV-uninfected children.
Do performance indicators predict regulator ratings of healthcare providers? Cross-sectional study of acute hospitals in England
Authors: Allen Thomas , Walshe Kieran , Proudlove Nathan , Sutton Matt
Published: September 2019

Objective

To determine whether a large set of care performance indicators (‘Intelligent Monitoring (IM)’) can be used to predict the Care Quality Commission’s (CQC) acute hospital trust provider ratings.

Design

The IM dataset and first-inspection ratings were used to build linear and ordered logistic regression models for the whole dataset (all trusts). This was repeated for subsets of the trusts, with these models then applied to predict the inspection ratings of the remaining trusts.

Setting

The United Kingdom Department of Health and Social Care’s Care Quality Commission is the regulator for all health and social care services in England. We consider their first-inspection cycle of acute hospital trusts (2013–2016).

Participants

All 156 English NHS acute hospital trusts.

Intervention(s)

None.

Main Outcome Measure(s)

Percentage of correct predictions and weighted kappa.

Results

Only 24% of the predicted overall ratings for the test sample were correct and the weighted kappa of 0.01 indicates very poor agreement between predicted and actual ratings. This lack of predictive power is also found for each of the rating domains.

Conclusion

While hospital inspections draw on a much wider set of information, the poor power of performance indicators to predict subsequent inspection ratings may call into question the validity of indicators, ratings or both. We conclude that a number of changes to the way performance indicators are collected and used could improve their predictive value, and suggest that assessing predictive power should be undertaken prospectively when the sets of indicators are being designed and selected by regulators.
Lost in Misconceptions about Social Identity Theory
Authors: Larson Deborah Welch , Shevchenko Alexei
Published: September 2019

Dissatisfied with their relative standing in the world, China and Russia are challenging the US-dominated liberal order. Could US accommodation of their status concerns reduce conflict? The psychological rationale for status accommodation is rooted in the insights of social identity theory (SIT), which argues that persistent status denial leads lower-status groups to “lash out.” Steven Ward (2017) objects that political scientists have misinterpreted SIT. In his view, impermeable group boundaries only affect individuals and do not lead to intergroup conflict. Ward's narrow critique overlooks the larger meaning and significance of SIT, which is about how frustration and anger over status barriers and unfair treatment motivate lower-status groups to challenge the status quo. Social competition is positional and zero-sum. Given the insights of SIT, Ward's recommendation that the United States demonstrate to China and Russia the futility of status competition is likely to provoke a backlash and increase the risk of military conflict. Instead, SIT implies a continuing process of status accommodation and efforts to maintain the legitimacy and stability of US leadership.
Augmented Experiences: Investigating the Feasibility of Virtual Reality as Part of a Workplace Wellbeing Intervention
Authors: Naylor Matthew , Morrison Ben , Ridout Brad , Campbell Andrew
Published: September 2019

This exploratory experiment tested the effect of two virtual reality (VR) relaxation interventions on measures of physiological arousal and affect, compared to a control. Forty-nine participants were randomly assigned to one of three conditions, all using the Oculus Rift. Participants wore a heart rate (HR) monitor and completed pre- and post-test surveys, including the positive and negative affect schedule, Likert-type and open feedback questions. Mixed repeated measures ANOVAs revealed significant reductions in HR and affect over time across all conditions, with a significant interaction identified for the breathing condition’s effect on negative affect. Participants were able to identify feeling relaxation, as well as influencing factors. Further, the majority expected, and supported, the introduction of VR interventions in their workplace and/or college, with privacy being a common concern. These results demonstrate the potential of VR augmented relaxation interventions with recommendations for further study provided.

RESEARCH HIGHLIGHTS

VR can potentially provide wellbeing interventions with a uniquely immersive quality Results suggest interactive and immersive VR experiences may facilitate relaxation and reduce stress Participants believe there may be substantial benefits to having VR wellbeing interventions at work and college.
Optimization of the MALDIxin test for the rapid identification of colistin resistance in Klebsiella pneumoniae using MALDI-TOF MS
Authors: Dortet Laurent , Broda Agnieszka , Bernabeu Sandrine , Glupczynski Youri , Bogaerts Pierre , Bonnin Rémy , Naas Thierry , Filloux Alain , Larrouy-Maumus Gerald
Published: September 2019

Background

With the dissemination of carbapenemase producers, a revival of colistin was observed for the treatment of infections caused by MDR Gram-negatives. Unfortunately, the increasing usage of colistin led to the emergence of resistance. In Klebsiella pneumoniae, colistin resistance arises through addition of 4-amino-l-arabinose (l-Ara4N) or phosphoethanolamine (pEtN) to the native lipid A. The underlying mechanisms involve numerous chromosome-encoded genes or the plasmid-encoded pEtN transferase MCR. Currently, detection of colistin resistance is time-consuming since it still relies on MIC determination by broth microdilution. Recently, a rapid diagnostic test based on MALDI-TOF MS detection of modified lipid A was developed (the MALDIxin test) and tested on Escherichia coli and Acinetobacter baumannii.

Objectives

Optimize the MALDIxin test for the rapid detection of colistin resistance in K. pneumoniae.

Methods

This optimization consists of an additional mild-acid hydrolysis of 15 min in 1% acetic acid. The optimized method was tested on a collection of 81 clinical K. pneumoniae isolates, including 49 colistin-resistant isolates (45 with chromosome-encoded resistance, 3 with MCR-related resistance and 1 with both mechanisms).

Results

The optimized method allowed the rapid (<30 min) identification of l-Ara4N- and pEtN-modified lipid A of K. pneumoniae, which are known to be the real triggers of polymyxin resistance. At the same time, it discriminates between chromosome-encoded and MCR-related polymyxin resistance.

Conclusions

The MALDIxin test has the potential to become an accurate tool for the rapid determination of colistin resistance in clinically relevant Gram-negative bacteria.
Integrase strand transfer inhibitor (INSTI)-resistance mutations for the surveillance of transmitted HIV-1 drug resistance
Authors: Tzou Philip L , Rhee Soo-Yon , Descamps Diane , Clutter Dana S , Hare Bradley , Mor Orna , Grude Maxime , Parkin Neil , Jordan Michael R , Bertagnolio Silvia , Schapiro Jonathan M , Harrigan P Richard , Geretti Anna Maria , Marcelin Anne-Geneviève , Shafer Robert W ,   on behalf of the WHO HIVResNet Working Groups
Published: September 2019

Background

Integrase strand transfer inhibitors (INSTIs) are expected to be widely adopted globally, requiring surveillance of resistance emergence and transmission.

Objectives

We therefore sought to develop a standardized list of INSTI-resistance mutations suitable for the surveillance of transmitted INSTI resistance.

Methods

To characterize the suitability of the INSTI-resistance mutations for transmitted HIV-1 drug resistance (TDR) surveillance, we classified them according to their presence on published expert lists, conservation in INSTI-naive persons, frequency in INSTI-treated persons and contribution to reduced in vitro susceptibility. Mutation prevalences were determined using integrase sequences from 17302 INSTI-naive and 2450 INSTI-treated persons; 53.3% of the INSTI-naive sequences and 20.0% of INSTI-treated sequences were from non-B subtypes. Approximately 10% of sequences were from persons who received dolutegravir alone or a first-generation INSTI followed by dolutegravir.

Results

Fifty-nine previously recognized (or established) INSTI-resistance mutations were present on one or more of four published expert lists. They were classified into three main non-overlapping groups: 29 relatively common non-polymorphic mutations, occurring in five or more individuals and significantly selected by INSTI treatment; 8 polymorphic mutations; and 22 rare mutations. Among the 29 relatively common INSTI-selected mutations, 24 emerged as candidates for inclusion on a list of INSTI surveillance drug-resistance mutations: T66A/I/K, E92G/Q, G118R, F121Y, E138A/K/T, G140A/C/S, Y143C/H/R/S, S147G, Q148H/R/K, N155H, S230R and R263K.

Conclusions

A set of 24 non-polymorphic INSTI-selected mutations is likely to be useful for quantifying INSTI-associated TDR. This list may require updating as more sequences become available from INSTI-experienced persons infected with HIV-1 non-subtype B viruses and/or receiving dolutegravir.
Conflicts of Interest in Inflammatory Bowel Disease Articles on UpToDate
Authors: Khan Rishad , Li Juana , Scaffidi Michael A , Gimpaya Nikko , Pivetta Bianca , Grover Samir C
Published: September 2019

Background

Financial conflicts of interest (FCOIs) are widespread in inflammatory bowel disease (IBD) and may be particularly important in point-of-care (POC) resources, such as UpToDate, that are used to aid clinical decision making. In this study, we determined the prevalence of industry payments from companies making biologic medications for IBD to contributors of UpToDate articles on IBD.

Methods

This cross-sectional analysis included UpToDate articles that mention the use of biologic medications for IBD. We collected the names of the contributors (authors and editors) and their disclosures on UpToDate. We then searched for their names on the Center for Medicare and Medicaid Open Payments database and compared the payment information from 2013 to 2018 with UpToDate's disclosures. We presented data per episode, which describes one instance of participation by one person in one article, regardless of whether that person contributed to multiple articles.

Results

We identified 23 articles on the treatment of Crohn's disease and ulcerative colitis that mentioned the use of biologic medications, with 86 total episodes. Sixty-two (72%) episodes involved FCOIs. The median payment associated with each episode was $$55 (interquartile range = $44 to $145,241). Contributors did not fully disclose FCOIs in 41 (48%) episodes. Deputy editors, who are required to be free of FCOIs, in general did not have substantial episodes involving FCOI.

Conclusions

We found that UpToDate articles on inflammatory bowel disease involve substantial FCOI, many of which are not disclosed. The presence of these FCOIs may hamper trust in the objectivity of treatment recommendations.
Genome survey and identification of polymorphic microsatellites provide genomic information and molecular markers for the red crab Charybdis feriatus (Linnaeus, 1758) (Decapoda: Brachyura: Portunidae)
Authors: Fang Shaobin , Wu Renxie , Shi Xi , Zhang Yin , Ikhwanuddin Mhd , Lu Jianxue , Xia Lianjun , Wu Qingyang , Ma Hongyu
Published: September 2019

We conducted a whole genome survey in the portunid crab Charybdis feriatus (Linnaeus, 1758) using Illumina sequencing platform and developed a set of polymorphic microsatellite loci. A total of 117.7 Gb of clean reads were generated, with 74× coverage of the estimated genome size of 1.4 Gb. The GC content, heterozygosity rate, and repeat sequence rate of the genome were estimated to be 40%, 1.1%, and 51%, respectively. A total of 3,779,209 microsatellites were identified from the genome. Sixty microsatellite loci were evaluated in a wild population of 40 individuals. As a result, 14 polymorphic microsatellite loci (23.3%) were obtained. The number of alleles (3 to 15), polymorphism information content (0.365 to 0.884), observed heterozygosity (0.050 to 0.975), and expected heterozygosity (0.450 to 0.907) per locus averaged 6.8, 0.652, 0.691, and 0.707, respectively. We show that the genome of C. feriatus has a high heterozygosity and repeat sequence rates, and provide a novel insight into the genome profile of marine crabs. The genetic markers developed in this study are potentially useful for studies on population dynamics and conservation genetics of C. feriatus and other species of brachyuran crabs.
Targeting accepted as a criterion to establish international jurisdiction in online EU trade mark infringement cases
Authors: Rosati Eleonora
Published: September 2019

Court of Justice of the European Union, AMS Neve Ltd and Others v Heritage Audio SL and Pedro Rodríguez Arribas, Case C-172/18, EU:C:2019:674, 5 September 2019 (‘AMS Neve’)

In its decision in AMS Neve, the Court of Justice of the European Union (CJEU) has adopted a dynamic reading of Article 97(5) of the EU Trade Mark Regulation 207/2009 (now Article 125(5) of Regulation 2017/1001) and clarified that—in the event of an infringement of an EU trade mark over the Internet—also the courts of the place at which the defendant’s activity is targeted have jurisdiction to hear the resulting action.
Historical Analysis: Editors’ Reflections on 50 Years of the Journal of Pediatric Psychology
Authors: Kazak Anne E , Roberts Michael C , Brown Ronald T , Holmbeck Grayson N , Koocher Gerald P , La Greca Annette M , Routh Donald , Willis Diane , Palermo Tonya M
Published: September 2019

Objective

This article provides an historical perspective on the Journal of Pediatric Psychology (JPP) on the occasion of its 50th anniversary.

Methods

Former and current editors of JPP participated in a symposium at the 2019 Society of Pediatric Psychology Annual Conference (SPPAC), each highlighting prominent types of articles published during their terms, the influence of these papers over time, and their reflections on the next 50 years of the journal. Their presentations were summarized and integrated for this article. Additional data on editorial teams, special issues, and publication metrics over time are included.

Results

The data demonstrate changes over time in the growth, scope, and impact of JPP. The article also shows the consistency in areas of emphasis over time. Anticipated topics for the future were quite consistent across editors and included increased use of technology, broader attention to teams and approaches, and methodological advances as the field will continue to grow.

Conclusions

This article provides an unusual collaboration among editors of JPP, providing an historical perspective on the journal’s growth over time and anticipation of continued impact into the future.
Formula size games for modal logic and μ-calculus
Authors: T Hella Lauri , S Vilander Miikka
Published: September 2019

We propose a new version of formula size game for modal logic. The game characterizes the equivalence of pointed Kripke models up to formulas of given numbers of modal operators and binary connectives. Our game is similar to the well-known Adler–Immerman game. However, due to a crucial difference in the definition of positions of the game, its winning condition is simpler, and the second player does not have a trivial optimal strategy. Thus, unlike the Adler–Immerman game, our game is a genuine two-person game. We illustrate the use of the game by proving a non-elementary succinctness gap between bisimulation invariant first-order logic $\textrm{FO}$ and (basic) modal logic $\textrm{ML}$. We also present a version of the game for the modal $\mu $-calculus $\textrm{L}_\mu $ and show that $\textrm{FO}$ is also non-elementarily more succinct than $\textrm{L}_\mu $.
The influence of inclinations on the dynamical stability of multi-planet systems
Authors: Wang Ying , Zhou Ji-lin , Liu Fu-yao , Sun Wei , Liu Hui-Gen , Yang Ming
Published: September 2019

A type of compactly spaced and comparably sized multi-exoplanet system similar to TRAPPIST-1 has been discovered recently. The stability of these systems is an important issue, requiring further study. We examined how the initial inclinations influence the stability of multi-planet systems and derived an empirical formula describing the dependence of the instability time-scale on planetary mass, space separation and initial inclination. We find the following. (i) If space separations between planets are greater than 12RH (mutual Hill radius), coplanar multi-planet systems with 10−6 ≤ μ ≤ 10−3 (reduced planetary mass μ = m/M*) will remain stable within 1010Tin (the innermost orbital period). (ii) If initial inclinations of planets are smaller than 10° and space separations are greater than 10RH, multi-planet systems consisting of ≥5 planets with μ ≥ 10−5 will remain stable within 1010Tin. (iii) Initial inclinations in [0°, 10°] have inconsequential effects on the instability time-scales of massive multi-planet systems (μ ≥ 10−5), because eccentricities (excited during evolution) dominate the stability of these systems. (iv) If the initial inclinations are large enough (≥10°), sharp increases of instability time-scales in groups with 10−3 ≥ μ ≥ 10−5 will be moderated. This article presents a comprehensive study of the influence of inclination on the stability of multi-planet systems and discusses critical space separations for a multi-planet system becoming unstable.
Observing AGN feedback with CO intensity mapping
Authors: Breysse Patrick C , Alexandroff Rachael M
Published: September 2019

Current models of galaxy formation require star formation in high-mass galaxies to be limited by poorly understood mechanisms of quasar feedback. Feedback processes can be studied by examining the molecular gas content of AGN hosts through the CO rotational ladder, but the complexity of these observations means that current data are limited to only extremely CO-bright objects. Upcoming CO intensity mapping experiments offer an opportunity for a less biased probe of quasar feedback. By correlating intensity maps with spectroscopic AGN surveys, we can obtain a measurement of the mean CO luminosity of a large population of quasars simultaneously. We show that experiments like COMAP, CCAT-prime, and CONCERTO have enough sensitivity to detect this cross-correlation if existing AGN observations are representative of the whole population, and to place interesting upper limits if they are not. Future surveys will be able to increase the precision of these measurements by orders of magnitude, allowing detailed studies of quasar properties across a wide range of cosmic history.
Photometry and spectroscopy of massive stars observed during K2 Campaign 8
Authors: Eidam Jéssica M , Andrade Laerte , Emilio Marcelo , Rabello-Soares M Cristina , Pereira Alan W , Janot-Pacheco Eduardo , Armstrong James D
Published: September 2019

We report in this paper spectroscopic and photometric analysis of eight massive stars observed during Campaign 8 of the Kepler/K2 mission from 2016 January to March. Spectroscopic data were obtained on these stars at OPD/LNA, Brazil, and their stellar parameters determined using sme. Periodic analyses of the light curves were performed through cleanest and period04 algorithms. Mass, luminosity, and radius of our stars were estimated employing cesam + posc grids. Three of our stars show significant periodicity. K2 ID 220679442 and K2 ID 220532854 have periods linked to the stellar rotation. K2 ID 220532854 has prominent silicon lines (Si ii 4128–4131 Å), a characteristic presented in the peculiar class of Ap magnetic main-sequence stars. However, in our spectral analysis, this object was found to be an evolved, luminous giant star. K2 ID 220466722 was revealed to be a δ Scuti variable, and 40 individual frequencies were determined for this star. No significant periodicity was found in the light curves for the remaining stars analysed in this work, besides the instrumental one.
Neutron star binary orbits in their host potential: effect on early r-process enrichment
Authors: Bonetti Matteo , Perego Albino , Dotti Massimo , Cescutti Gabriele
Published: September 2019

Coalescing neutron star binary (NSB) systems are primary candidates for r-process enrichment of galaxies. The recent detection of r-process elements in ultrafaint dwarf (UFD) galaxies and the abundances measured in classical dwarfs challenges the NSB merger scenario both in terms of coalescence time-scales and merger locations. In this paper, we focus on the dynamics of NSBs in the gravitational potentials of different types of host galaxies and on its impact on the subsequent galactic enrichment. We find that, for a ∼t−1 delay time distribution, even when receiving a low kick (∼10 km s−1) from the second supernova explosion, in shallow dwarf galaxy potentials NSBs tend to merge with a large off-set from the host galaxy. This results in a significant geometrical dilution of the amount of produced r-process elements that fall back and pollute the host galaxy gas reservoir. The combination of dilution and small number statistics produces a large scatter in the expected r-process enrichment within a single UFD or classical dwarf galaxy. Comparison between our results and observed europium abundances reveals a tension that even a systematic choice of optimistic parameters in our models cannot release. Such a discrepancy could point to the need of additional r-process production sites that suffer less severe dilution or to a population of extremely fast merging binaries.
stroopwafel: simulating rare outcomes from astrophysical populations, with application to gravitational-wave sources
Authors: Broekgaarden Floor S , Justham Stephen , de Mink Selma E , Gair Jonathan , Mandel Ilya , Stevenson Simon , Barrett Jim W , Vigna-Gómez Alejandro , Neijssel Coenraad J
Published: September 2019

Gravitational-wave observations of double compact object (DCO) mergers are providing new insights into the physics of massive stars and the evolution of binary systems. Making the most of expected near-future observations for understanding stellar physics will rely on comparisons with binary population synthesis models. However, the vast majority of simulated binaries never produce DCOs, which makes calculating such populations computationally inefficient. We present an importance sampling algorithm, stroopwafel, that improves the computational efficiency of population studies of rare events, by focusing the simulation around regions of the initial parameter space found to produce outputs of interest. We implement the algorithm in the binary population synthesis code compas, and compare the efficiency of our implementation to the standard method of Monte Carlo sampling from the birth probability distributions. stroopwafel finds ∼25–200 times more DCO mergers than the standard sampling method with the same simulation size, and so speeds up simulations by up to two orders of magnitude. Finding more DCO mergers automatically maps the parameter space with far higher resolution than when using the traditional sampling. This increase in efficiency also leads to a decrease of a factor of ∼3–10 in statistical sampling uncertainty for the predictions from the simulations. This is particularly notable for the distribution functions of observable quantities such as the black hole and neutron star chirp mass distribution, including in the tails of the distribution functions where predictions using standard sampling can be dominated by sampling noise.
Simple interpolation functions for the galaxy-wide stellar initial mass function and its effects in early-type galaxies
Authors: Dabringhausen J
Published: September 2019

The galaxy-wide stellar initial mass function (IGIMF) of a galaxy is thought to depend on its star formation rate (SFR). Using a catalogue of observational properties of early-type galaxies (ETGs) and a relation that correlates the formation time-scales of ETGs with their stellar masses, the dependencies of the IGIMF on the SFR are translated into dependencies on more intuitive parameters like present-day luminosities in different passbands. It is found that up to a luminosity of approximately 109 L⊙ (quite independent of the considered passband), the total masses of the stellar populations of ETGs are slightly lower than expected from the canonical stellar initial mass function (IMF). However, the actual mass of the stellar populations of the most luminous ETGs may be up to two times higher than expected from a simple stellar population model with the canonical IMF. The variation of the IGIMF with the mass of ETGs is presented here also as convenient functions of the luminosity in various passbands.
Tentative detection of the circumgalactic medium of the isolated low-mass dwarf galaxy WLM
Authors: Zheng Yong , Putman Mary E , Emerick Andrew , McQuinn Kristen B W , Werk Jessica K , Lockman Felix J , Oppenheimer Benjamin D , Fox Andrew J , Kirby Evan N , Burchett Joseph N
Published: September 2019

We report a tentative detection of the circumgalactic medium (CGM) of Wolf–Lundmark–Melotte (WLM), an isolated, low-mass (logM*/M⊙ ≈ 7.6), dwarf irregular galaxy in the Local Group (LG). We analyse an HST/COS archival spectrum of a quasar sightline (PHL2525), which is 45 kpc (0.5 virial radius) from WLM and close to the Magellanic Stream (MS). Along this sightline, two ion absorbers are detected in Si ii, Si iii, Si iv, C ii, and C iv at velocities of ∼−220 km s−1 (Component v-220) and ∼−150 km s−1 (Component v-150). To identify their origins, we study the position–velocity alignment of the components with WLM and the nearby MS. Near the magellanic longitude of PHL2525, the MS-related neutral and ionized gas moves at ≲−190 km s−1, suggesting an MS origin for Component v-220, but not for Component v-150. Because PHL2525 passes near WLM and Component v-150 is close to WLM’s systemic velocity (∼−132 km s−1), it is likely that Component v-150 arises from the galaxy’s CGM. This results in a total Si mass in WLM’s CGM of $M_{\rm Si}^{\rm CGM}\sim (0.2-1.0)\times 10^5~\mathrm{M}_\odot$ using assumption from other COS dwarf studies. Comparing $M_{\rm Si}^{\rm CGM}$ to the total Si mass synthesized in WLM over its lifetime (∼1.3 × 105 M⊙), we find ∼3 per cent is locked in stars, ∼6 per cent in the ISM, ∼15–77 per cent in the CGM, and the rest (∼14–76 per cent) is likely lost beyond the virial radius. Our finding resonates with other COS dwarf galaxy studies and theoretical predictions that low-mass galaxies can easily lose metals into their CGM due to stellar feedback and shallow gravitational potential.
Role of cosmic-ray streaming and turbulent damping in driving galactic winds
Authors: Holguin F , Ruszkowski M , Lazarian A , Farber R , Yang H-Y K
Published: September 2019

Large-scale galactic winds driven by stellar feedback are one phenomenon that influences the dynamical and chemical evolution of a galaxy, redistributing material throughout the circumgalatic medium. Non-thermal feedback from galactic cosmic rays (CRs) – high-energy charged particles accelerated in supernovae and young stars – can impact the efficiency of wind driving. The streaming instability limits the speed at which they can escape. However, in the presence of turbulence, the streaming instability is subject to suppression that depends on the magnetization of turbulence given by its Alfvén Mach number. While previous simulations that relied on a simplified model of CR transport have shown that super-Alfvénic streaming of CRs enhances galactic winds, in this paper we take into account a realistic model of streaming suppression. We perform three-dimensional magnetohydrodynamic simulations of a section of a galactic disc and find that turbulent damping dependent on local magnetization of turbulent interstellar medium (ISM) leads to more spatially extended gas and CR distributions compared to the earlier streaming calculations, and that scale heights of these distributions increase for stronger turbulence. Our results indicate that the star formation rate increases with the level of turbulence in the ISM. We also find that the instantaneous wind mass loading is sensitive to local streaming physics with the mass loading dropping significantly as the strength of turbulence increases.