bluuebunny/crossref_metadata_2025 huggingface dataset:
Prostate Cancer Risk Stratification by Digital Histopathology and Deep Learning
Authors: Shao Yanan , Bazargani Roozbeh , Karimi Davood , Wang Jane , Fazli Ladan , Goldenberg S. Larry , Gleave Martin E. , Black Peter C. , Bashashati Ali , Salcudean Septimiu
Published: June 2024

PURPOSE

Prostate cancer (PCa) represents a highly heterogeneous disease that requires tools to assess oncologic risk and guide patient management and treatment planning. Current models are based on various clinical and pathologic parameters including Gleason grading, which suffers from a high interobserver variability. In this study, we determine whether objective machine learning (ML)–driven histopathology image analysis would aid us in better risk stratification of PCa.

MATERIALS AND METHODS

We propose a deep learning, histopathology image–based risk stratification model that combines clinicopathologic data along with hematoxylin and eosin– and Ki-67–stained histopathology images. We train and test our model, using a five-fold cross-validation strategy, on a data set from 502 treatment-naïve PCa patients who underwent radical prostatectomy (RP) between 2000 and 2012.

RESULTS

We used the concordance index as a measure to evaluate the performance of various risk stratification models. Our risk stratification model on the basis of convolutional neural networks demonstrated superior performance compared with Gleason grading and the Cancer of the Prostate Risk Assessment Post-Surgical risk stratification models. Using our model, 3.9% of the low-risk patients were correctly reclassified to be high-risk and 21.3% of the high-risk patients were correctly reclassified as low-risk.

CONCLUSION

These findings highlight the importance of ML as an objective tool for histopathology image assessment and patient risk stratification. With further validation on large cohorts, the digital pathology risk classification we propose may be helpful in guiding administration of adjuvant therapy including radiotherapy after RP.
Safety, Efficacy, and Pharmacokinetics of SHR-A1811, a Human Epidermal Growth Factor Receptor 2–Directed Antibody-Drug Conjugate, in Human Epidermal Growth Factor Receptor 2–Expressing or Mutated Advanced Solid Tumors: A Global Phase I Trial
Authors: Yao Herui , Yan Min , Tong Zhongsheng , Wu Xinhong , Ryu Min-Hee , Park John J. , Kim Jee Hyun , Zhong Yahua , Zhao Yiming , Voskoboynik Mark , Yin Yongmei , Liu Kan , Kaubisch Andreas , Liu Caigang , Zhang Jian , Wang Shouman , Im Seock-Ah , Ganju Vinod , Barve Minal , Li Hui , Ye Changsheng , Roy Amitesh C. , Bai Li-Yuan , Yen Chia-Jui , Gu Shanzhi , Lin Yung-Chang , Wu Lingying , Bao Lequn , Zhao Kaijing , Shen Yu , Rong Shangyi , Zhu Xiaoyu , Song Erwei
Published: June 2024

PURPOSE

SHR-A1811 is an antibody-drug conjugate composed of an anti–human epidermal growth factor receptor 2 (HER2) antibody trastuzumab, a cleavable linker, and a topoisomerase I inhibitor payload. We assessed the safety, tolerability, antitumor activity, and pharmacokinetics of SHR-A1811 in heavily pretreated HER2-expressing or mutated advanced solid tumors.

METHODS

This global, multi-center, first-in-human, phase I trial was conducted at 33 centers. Patients who had HER2-expressing or mutated unresectable, advanced, or metastatic solid tumors and were refractory or intolerant to standard therapies were enrolled. SHR-A1811 was administered intravenously at doses ranging from 1.0 to 8.0 mg/kg once every 3 weeks. The primary end points were dose-limiting toxicity, safety, and the recommended phase II dose.

RESULTS

From September 7, 2020, to February 27, 2023, 307 patients who had undergone a median of three (IQR, 2-5) previous treatment regimens in the metastatic setting received SHR-A1811 treatment. As of data cutoff (February 28, 2023), one patient from the 6.4 mg/kg group experienced dose-limiting toxicities (pancytopenia and colitis). The most common grade 3 or higher adverse events (AEs) included decreased neutrophil count (119 [38.8%]) and decreased WBC count (70 [22.8%]). Interstitial lung disease occurred in only eight (2.6%) patients. Serious AEs and deaths occurred in 70 (22.8%) and 13 (4.2%) patients, respectively. SHR-A1811 led to objective responses in 59.9% (184/307) of all patients, 76.3% (90/118) of HER2-positive breast cancer, 60.4% (55/91) of HER2 low-expressing breast cancer, and 45.9% (39/85 with evaluable tumor responses) of the 98 nonbreast tumors.

CONCLUSION

SHR-A1811 exhibited acceptable tolerability, promising antitumor activity, and a favorable pharmacokinetic profile in heavily pretreated advanced solid tumors. The recommended phase II dose of 4.8 or 6.4 mg/kg was selected for various tumor types.
Phase I Study of Fianlimab, a Human Lymphocyte Activation Gene-3 (LAG-3) Monoclonal Antibody, in Combination With Cemiplimab in Advanced Melanoma
Authors: Hamid Omid , Lewis Karl D. , Weise Amy , McKean Meredith , Papadopoulos Kyriakos P. , Crown John , Kim Tae Min , Lee Dae Ho , Thomas Sajeve S. , Mehnert Janice , Kaczmar John , Lakhani Nehal J. , Kim Kevin B. , Middleton Mark R. , Rabinowits Guilherme , Spira Alexander I. , Yushak Melinda , Mehmi Inderjit , Fang Fang , Chen Shuquan , Mani Jayakumar , Jankovic Vladimir , Wang Fang , Fiaschi Nathalie , Brennan Laura , Paccaly Anne , Masinde Sheila , Salvati Mark , Fury Matthew G. , Kroog Glenn , Lowy Israel , Gullo Giuseppe
Published: June 2024

PURPOSE

Coblockade of lymphocyte activation gene-3 (LAG-3) and PD-1 receptors could provide significant clinical benefit for patients with advanced melanoma. Fianlimab and cemiplimab are high-affinity, human, hinge-stabilized IgG4 monoclonal antibodies, targeting LAG-3 and PD-1, respectively. We report results from a first-in-human phase-I study of fianlimab and cemiplimab safety and efficacy in various malignancies including advanced melanoma.

METHODS

Patients with advanced melanoma were eligible for enrollment into four cohorts: three for patients without and one for patients with previous anti–PD-1 therapy in the advanced disease setting. Patients were treated with fianlimab 1,600 mg and cemiplimab 350 mg intravenously once every 3 weeks for up to 51 weeks, with an optional additional 51 weeks if clinically indicated. The primary end point was objective response rate (ORR) per RECIST 1.1 criteria.

RESULTS

ORRs were 63% for patients with anti–PD-1–naïve melanoma (cohort-6; n = 40; median follow-up 20.8 months), 63% for patients with systemic treatment–naïve melanoma (cohort-15; n = 40; 11.5 months), and 56% for patients with previous neo/adjuvant treatment melanoma (cohort-16; n = 18, 9.7 months). At a median follow-up of 12.6 months for the combined cohorts (6 + 15 + 16), the ORR was 61.2% and the median progression-free survival (mPFS) 13.3 months (95% CI, 7.5 to not estimated [NE]). In patients (n = 13) with previous anti–PD-1 adjuvant therapy, ORR was 61.5% and mPFS 12 months (95% CI, 1.4 to NE). ORR in patients with previous anti–PD-1 therapy for advanced disease (n = 15) was 13.3% and mPFS 1.5 months (95% CI, 1.3 to 7.7). Treatment-emergent and treatment-related adverse events ≥grade 3 (G3) were observed in 44% and 22% of patients, respectively. Except for increased incidence of adrenal insufficiency (12%-G1-4, 4%-G3-4), no new safety signals were recorded.

CONCLUSION

The current results show a promising benefit-risk profile of fianlimab/cemiplimab combination for patients with advanced melanoma, including those with previous anti–PD-1 therapy in the adjuvant, but not advanced, setting.
Anti/social Abolitionism
Authors: Hammes Aaron
Published: June 2024

It has been almost twenty years since Lee Edelman's No Future manifesto emerged as a shot across the bow of the cis/heteronormative future of “The Child,” as well as an early entry in the “antisocial turn” in queer studies. It has also been nearly fifteen years since José Esteban Muñoz's ruminations on queer futurity and “anti-antirelational” queerness in Cruising Utopia. More recently, Virginie Despentes writes of former paramour Paul Preciado's desire for a “utopian gender,” adding another wrinkle to the prospects for sex-gender dissidents to imagine a future in which their lives and livelihoods escape state surveillance, phobic publics, and legal obstacles to self-determination. This article attempts to craft a utopian pyramid, first comparing the rhetorics of No Future, Cruising Utopia, and Preciado's Apartment on Uranus for some versions of still-emergent and nascent utopian knowledge projects. Then, another triangle, this one of utopian political projects: police/prison abolition, sex work decriminalization/destigmatization, and visions of queer/trans liberation. The author attempts to outline shared discursive strategies between these projects and how they inflect both the antisocial and the utopic. How do struggles for queer and trans liberation and minoritarian self-determination necessarily implicate anti-carceral logics, not least around the highly sex-gendered, classed, and racialized labor of the sex trades?
Multi-omics analysis of diabetic pig lungs reveals molecular derangements underlying pulmonary complications of diabetes mellitus
Authors: Shashikadze Bachuki , Flenkenthaler Florian , Kemter Elisabeth , Franzmeier Sophie , Stöckl Jan B. , Haid Mark , Riols Fabien , Rothe Michael , Pichl Lisa , Renner Simone , Blutke Andreas , Wolf Eckhard , Fröhlich Thomas
Published: June 2024

Growing evidence shows that the lung is an organ prone to injury by diabetes mellitus. However, the molecular mechanisms of these pulmonary complications have not yet been characterized comprehensively. To systematically study the effects of insulin deficiency and hyperglycaemia on the lung, we combined proteomics and lipidomics with quantitative histomorphological analyses to compare lung tissue samples from a clinically relevant pig model for mutant INS gene-induced diabetes of youth (MIDY) with samples from wild-type littermate controls. Among others, the level of pulmonary surfactant-associated protein A (SFTPA1), a biomarker of lung injury, was moderately elevated. Furthermore, key proteins related to humoral immune response and extracellular matrix organization were significantly altered in abundance. Importantly, a lipoxygenase pathway was dysregulated as indicated by 2.5-fold reduction of polyunsaturated fatty acid lipoxygenase ALOX15 levels, associated with corresponding changes in the levels of lipids influenced by this enzyme. Our multi-omics study points to an involvement of reduced ALOX15 levels and an associated lack of eicosanoid switching as mechanisms contributing to a proinflammatory milieu in the lungs of subjects with diabetes mellitus.
Benzydamine induces apoptosis in astrocytes in vitro
Authors: Lima Feitosa Mariana , Viana da Silva Costa Deiziane , Maria Martins Teixeira Izabell , Lima Sampaio Tiago , Roseo Paula Pessoa Bezerra de Menezes Ramon , Macedo Gaspar Danielle , Costa Martins Alice Maria , De Castro Brito Gerly Anne , Florenço de Sousa Francisca Cléa
Published: June 2024

Objective: the present work aims to evaluate the Benzydamine (BZD) effect on cell viability in astrocyte culture and investigated the death mechanism involved with its cytotoxic effect. Methods: in order to evaluate cell viability, the 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) reduction assay was used, while flow cytometry was used to verify cell damage. The immunofluorescence assay was used to verify the expression of the marker’s caspase-8, caspase9 and p65 subunit of Factor nuclear kappa B (NFκB). A statistical analysis for MTT assay and Flow Cytometry were made using ANOVA with Dunett’s post-test; Student's t-test was made for the Immunofluorescence. Significance was set at p < 0.05. Results: the MTT reduction assay showed that BZD (3.1 to 100 μg/mL) caused a decrease in astrocytes viability. The flow cytometry showed that the cytotoxic effect of BZD was caused by the activation of the apoptotic death pathway, evidenced by the externalization of phosphatidylserine. The immunofluorescence revealed an increase in caspase-8 expression and no alteration in caspase-9 expression, demonstrating that there was an activation of the extrinsic pathway of apoptosis. The mean inhibitory concentration (IC50) of BZD (26.13 μg/mL) also caused an increase in NFκB p65 expression. Conclusion: taken together, the results of the present study suggest that BZD has a cytotoxic effect on astrocyte cells, and this effect comes from its ability to activate the extrinsic apoptotic pathway.
Clinical Study on the treatment of chronic infectious ulcers using Platelet-Rich technology combined with moist dressings
Authors: Zhang Xu , Lang Zhigang
Published: June 2024

Objective: To explore the clinical efficacy of platelet-rich technology combined with moist dressings in the treatment of chronic infectious ulcers.
Methods: This was a retrospective study. The subjects of the study were 48 patients with chronic infectious ulcers in Sichuan Provincial Orthopedics Hospital from January 2019 to June 2022. Enrolled patients were randomly divided into four groups(n=12), and received different treatment methods respectively. Further analysis and comparison were performed on the changes in wound volume, wound healing status, wound bacterial culture results, and the incidence of adverse reactions among the four groups.
Results: Three months after debridement, the wound volume of all four groups of patients was significantly reduced compared with that before debridement, with a statistically significant difference in intra-Group-Comparison(P<0.05). The inter-Group-Comparison revealed a statistically significant difference in wound volume in Group-A, Group-B, and Group-C than that in Group-D(P<0.05). After treatment, the wound healing status of patients in groups A, B, and C was significantly better than that of patients in Group-D, with a statistically significant difference(P<0.05). During treatment, patients in all four groups had decreased count of would bacteria, and showed negative results of wound bacterial culture by the three-month follow-up. No serious adverse reactions were observed in the four groups during treatment, and all improved after management, with no statistically significant difference in the incidence of adverse reactions(P>0.05).
Conclusion: Platelet-rich technology combined with moist dressings may effectively promote the repair of chronic infectious ulcer wounds, with good clinical safety.
doi: https://doi.org/10.12669/pjms.40.7.8468
How to cite this: Zhang X, Lang Z. Clinical Study on the treatment of chronic infectious ulcers using Platelet-Rich technology combined with moist dressings. Pak J Med Sci. 2024;40(7):---------. doi: https://doi.org/10.12669/pjms.40.7.8468
This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Prevalence, serovars, and risk factors associated with the presence of Salmonella in pork sold in public markets in Quito, Ecuador
Authors: Vinueza-Burgos Christian , Hidalgo-Arellano Luis , Gómez-Coronado Carlos , Medina-Santana José Luis , Cevallos-Almeida María
Published: June 2024

Background Salmonella enterica are bacteria that include more than 2,500 serovars. Most of these serovars have been linked to human foodborne illnesses, mainly related to poultry and pigs. Thus, these animals are considered the reservoirs of many Salmonella serovars and strains related to antibiotic resistance. This study aimed to determine the prevalence, serovars, β-lactam resistance genes, and the risk factors associated with Salmonella enterica in pork commercialized in open markets of Quito city. Methods For this, 165 pork meat samples were taken from municipal markets in three areas in the city. These samples were microbiologically processed following the ISO 6579-2014 standardized method. The polymerase chain reaction (PCR) test was used to identify Salmonella serotyping and resistance genes. Strains not identified by PCR were typed by the Kauffman White Le Minor scheme. A multivariate analysis was performed to identify risk factors associated with the presence of the microorganism. Results Salmonella prevalence in pork was 9.1%. Identified serovars were 4, [5], 12: i:- (53.3%), Infantis (33.3%), and Derby (13.4%). Furthermore, the β-lactam resistance genes bla CTX-M-65 could be identified in three S. infantis isolates. Multivariate analysis showed that temperature (above 8°C) and cutting surfaces (wood) presented significant association values. Conclusions In conclusion, pork in traditional markets of Quito is contaminated with Salmonella enterica, whose main serovars pose a public health concern, and shows beta-lactam resistance.
El transhumanismo frente a la discapacidad: El caso de Neil Harbisson.
Authors: Castagnedi Ramirez Alessandra Esther
Published: June 2024

El transhumanismo emerge como una corriente filosófica prominente que aboga por la mejora de la condición humana a través de la tecnología. Este artículo explora la relación entre transhumanismo y discapacidad, centrándose en el caso de Neil Harbisson, un artista y ciborg que nació con acromatopsia y que se implantó un dispositivo que le permite escuchar colores. Se analizan las implicaciones éticas y filosóficas de la tecnología en la superación de limitaciones humanas y se reflexiona sobre cómo los avances tecnológicos pueden potenciar la calidad de vida de las personas con discapacidades, resaltando la importancia de una responsabilidad ética y social en el desarrollo tecnológico.
How to Design the Ask? Funding Units vs. Giving Money
Authors: Epperson Raphael , Diederich Johannes , Goeschl Timo
Published: June 2024

Unit donations are an alternative fundraising scheme in which potential donors choose how many units of a charitable good to fund rather than just giving money. Based on evidence from an online experiment with 8,673 participants, we demonstrate that well-designed unit donation schemes can significantly boost giving above and beyond the standard money donation scheme. A decomposition of the underlying mechanisms shows patterns consistent with the conjecture that unit donations increase impact salience and leverage donors’ cognitive biases by changing the metric of the donation space. Managers need to weigh the potential fundraising benefits of a unit scheme against some important challenges, such as expert handling of the choice of unit sizes.

This paper was accepted by Yan Chen, behavioral economics and decision analysis.

Funding: Funding by Heidelberg University [Field of Focus IV under the Excellence Strategy] and the Austrian Science Fund [Grant SFB F63] is gratefully acknowledged.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2021.00157 .
Evaluasi Adaptasi Kondisi Termal Gereja Cagar Budaya di Lingkungan Tropis Perkotaan (Studi Kasus: GPIB Immanuel Kota Malang)
Authors: Samodra FX Teddy Badai , Ekasiwi Sri Nastiti Nugrahani , Antaryama I Gusti Ngurah , Defiana Ima , Sudarma Erwin
Published: June 2024

Selaras dengan salah satu tujuan dari pembangunan berkelanjutan dalam bidang pemukiman (habitation), yaitu membangun kota dan permukiman yang inklusif, sehat, aman, awet, dan berkelanjutan, maka kualitas lingkungan yang baik menjadi penting. GPIB (Gereja Protestan di Indonesia bagian Barat) Immanuel Kota Malang merupakan bangunan cagar budaya yang berada di daerah beriklim tropis lembap, di lingkungan perkotaan padat bangunan. Tujuan dari kegiatan pengabdian pada masyarakat ini adalah menyelesaikan permasalahan yang disampaikan oleh Mitra GPIB terkait kondisi tempat ibadah yang tidak nyaman secara termal. Metode pengabdian pada masyarakat dilaksanakan dengan pengukuran, simulasi/ perhitungan, dan analisis termal eksisting yang diselesaikan dengan pemasangan pengkondisi udara, namun masih ada keluhan penataan yang harmonis dan estetis. Hasil dari kegiatan ini berupa rancangan usulan perbaikan kondisi lingkungan di ruang ibadah. Seiring dengan program pengembangan sarana dan prasarana ibadah sebagai bangunan cagar budaya, peningkatan kondisi lingkungan diutamakan dengan mempertahankan kualitas sebagai bangunan yang dilindungi pemerintah.
Pengembangan Kawasan Halal Desa Kare, Kabupaten Madiun Melalui Kampanye Gerakan Menuju Sertifikasi Halal (GEMESH)
Authors: Putro Herdayanto Sulistyo , Purnomo Adi Setyo , Rizqi Hamdan Dwi , Putra Surya Rosa , Wilujeng Susi Agustina , Indrawan Iwan Adi , Zahra Ema Azzah Aulia , Oktafia Galuh Krisna , Azzahira Sabira , Abdillah Salsabilah Putri , Yediya Hanna , Sabilla Wardatus , Pangayom Danang Luhur , Nurhayati Alfia , Yulianengtias Andira , Prasetiyowati Mega , Aldianita Ananda Krisna
Published: June 2024

Pertumbuhan ekonomi pada suatu negara merupakan aspek penting dalam ketahanan negara dalam mencukupi kebutuhan perekonomian rakyatnya. Kurangnya sosialisasi serta minimnya literasi pelaku UMKM menjadi faktor terbesar dalam ketidaktahuan pelaku UMKM terkait kebijakan kehalalan produk di Indonesia. Kegiatan ini merupakan kegiatan yang berorientasi pada tujuan untuk mengajak UMKM agar lebih sadar akan penting dan manfaatnya dari sertifikasi halal bagi produk-produk mereka. Prosedur kegiatan meliputi Pelatihan Kader Penggerak Halal, Pendampingan Penyusunan Manual Sistem Jaminan Halal, Sosialisasi Kebijakan Halal, Pendaftaran Sertifikasi Halal, Pemasaran Produk dan Kampanye. Eksplorasi kegiatan dilakukan di Desa Kare, Kabupaten Madiun, Jawa Timur. Target kegiatan meliputi beberapa UMKM dengan variasi produk berbeda seperti camilan, jamu, kue basah, bakery, keripik, peyek dan sambal pecel, rengginang, ayam bakar, dll. Prosedur pengolahan dan bahan yang digunakan sebagai kunci identifikasi kehalalan produk. Hasil analisis menunjukkan bahwa UMKM Desa Kare telah memenuhi untuk mendapatkan pendampingan proses sertifikasi halal di BPJPH dan LPH LPPOM MUI, serta telah mendapatkan fasilitas untuk peningkatan nilai produk olahan makanan dan minuman dengan melakukan strategi pemasaran.
Mesin Pengering Hasil Pertanian Bertenaga Hybrid dan Portabel pada Pemukiman Terpencil di Desa Broto, Kecamatan Slahung, Ponorogo, Jawa Timur
Authors: Al Kindhi Berlian , Aliffianto Lutfir Rahman , Wicaksono Ilham Agung , Farid Imam Wahyudi , Adhim Fauzi Imaduddin , Priambodo Joko , Khothib Abdurrohman Al , Khatulistiwa Savero Janus , Prakoso Reno Radix , Brillianto Muhammad Rakha , Nasrulloh Fikri Ahmad Dwi , Ghiffari Muhammad Ilham , Utama Harris Fikri Satria , Pramudhita Alfian Samudra
Published: June 2024

Desa Broto, Kecamatan Slahung, Kabupaten Ponorogo merupakan salah satu desa yang terletak di ujung paling selatan perbatasan antara Ponorogo dan Pacitan, Jawa Timur. Lokasinya yang berada di pegunungan dan jauh dari pusat kota menjadikan petani adalah mata pencaharian utama penduduk disana. Pada saat panen padi, untuk memisahkan biji padi dari sekamnya harus dijemur dan dikeringkan terlebih dahulu. Selama ini proses penjemuran beras dilakukan secara manual sehingga memakan banyak waktu dan tenaga. Selain itu,cuaca di pegunungan tidak menentu, terkadang sinar matahari tertutup kabut walaupun di musim panas, mengakibatkan proses pengeringan beras menjadi lebih lama. Oleh karena itu kami mengusulkan desain alat pengering beras dan produk pertanian lainnya dengan tenaga hybrid dan portable. Mesin pengering yang kami usulkan memiliki sumber energi dari listrik PLN maupun listrik dari tenaga surya. Dengan adanya penyimpanan energi dari tenaga surya ke dalam baterai, alat yang diusulkan menjadi mudah di mobilisasi ke area-area sawah tanpa perlu memikirkan sumber listrik. Melalui pemanfaatan mesin pengering bertenaga hybrid ini, hasil padi kering di Desa Broto menjadi 3-5% lebih banyak dibandingkan pengeringan cara manual dengan perhitungan seluruh hasil panen dan penambahan satu mesin tenaga hybrid.
Model Pelatihan Kelayakan Finansial dan Pasar untuk UMKM Konstruksi dan Usaha Pendukungnya
Authors: Utomo Christiono , Nurcahyo Cahyono Bintang , Rachmawati Farida , Wiguna I Putu Artama , Rohman M. Arif , Indriyani Retno , Adi Tri Joko Wahyu , Putri Yusronia Eka
Published: June 2024

Studi Kelayakan adalah salah satu tahap dalam pengembangan proyek yaitu setelah tahap ide dan penyempurnaan ide melalui riset pasar. Ketika ide pengembangan proyek akan diujudkan diperlukan suatu keputusan apakah proyek tersebut memungkinkan untuk dikembangkan. Beberapa tinjauan diantaranya adalah aspek sistem dan teknologi, operasional, legal, pasar, dan finansial. Dalam menjalankan bisnisnya, sebuah perusahaan konstruksi akan membuat pertimbangan bisnis dan proyek berdasarkan tinjauan tersebut. UMKM memiliki kepentingan untuk meningkatkan pemahaman dan memiliki kemampuan kelayakan proyek dalam hal keunggulan kinerja. Kebutuhan untuk meningkatkan pengetahuan dan ketrampilan dapat dipenuhi melalui kegiatan pelatihan dan pengembangan. Pelatihan pengabdian masyarakat dan KKN mahasiswa ini dilakukan setiap tahun oleh Laboratorium Manajemen Konstruksi DTS ITS. Untuk tahun ini adalah pelatihan pengembangan pengetahuan dan ketrampilan studi kelayakan dengan tiga fokus bahasan utama adalah kelayakan pasar, finansial, dan studi kasus penyusunan. Ada 29 peserta dari 16 UMKM konstruksi dan usaha pendukungnya di Surabaya. Sebagian besar peserta adalah project owner. Pelatihan dilaksanakan dengan model problem-based learning. Diharapkan kegiatan dapat berkelanjutan dan menghasilkan rumusan kerjasama pengabdian masyarakat dalam jangka panjang melalui terdesiminasinya keilmuan kelayakan proyek bagi UMKM konstruksi di Surabaya.
Sistem Monitoring dan Kontrol Otomatis Terintegrasi IoT pada Vertical Crab House untuk Meningkatkan Potensi Hidup Kepiting Bakau di PT. Crab Crab Aquatic
Authors: Mujiyanti Safira Firdaus , Raditya Murry , Nugroho Dwi Oktavianto Wahyu , Darwito Purwadi Agus , Septyaningrum Erna , Zein Muhammad Ikhsanuddin , Lokeswara Rajendra , Rishwanda Muhammad Akmal , Darmawan Tiffany Rachmania , Rohid Abdul , Nanta Tepy Lindia
Published: June 2024

Budidaya kepiting bakau dengan Vertical Crab House menjadi alternatif pembesaran kepiting dengan lahan terbatas untuk memenuhi permintaan di perkotaan. Namun masih banyak resiko kematian kepiting bakau disebabkan proses pengendalian kualitas air masih manual dalam mengendalikan kualitas air sirkulasi. Hal ini membutuhkan tenaga manusia dan waktu ekstra untuk memastikan kualitas air sirkulasi sesuai dengan kondisi lingkungan pertumbuhan kepiting bakau. Ditambah lagi metode Vertical Crab House tidak dapat mengidentifikasi kondisi kualitas air secara tepat, tidak dapat mengecek kondisi kualitas air secara real-time, dan tidak dapat mengecek kondisi temperatur, salinitas, amonia, dan pH secara simultan. Kondisi lingkungan yang tidak sesuai dengan parameter dan tidak termonitor membuat resiko kematian kepiting bakau masih sangat tinggi sehingga menyebabkan pembudidaya mengalami kerugian yang cukup besar. Permasalahan tersebut menjadi dasar terciptanya sistem otomatisasi pengendalian kualitas air untuk mengoptimalkan proses budidaya kepiting bakau dengan metode Vertical Crab House. Proses pengendalian kualitas air tersebut dilakukan dengan memasang sensor, kontroler, dan aktuator yang diintegrasikan sehingga proses pengendalian kualitas air dapat berjalan terus-menerus untuk memastikan air yang tersirkulasi sesuai dengan lingkungan yang optimal bagi pertumbuhan kepiting bakau. Selain itu, kualitas air sirkulasi pada budidaya dapat dipantau secara real-time melalui aplikasi smartphone.
Identifikasi dan Pengendalian Potensi Bahaya K3 dan Ergonomi pada Proses Produksi Batik Ecoprint UMKM Omah Ecoprint
Authors: Dewi Ratna Sari , Rizkiyah Ega , Istighfarin Rahmatul , Sudiarno Adithya , Rahman Arief , Dewi Dyah Santhi , Maryani Anny , Amardhani Athaa Faishal , Sholah Adam Fajrus , Bimantara Alvin , Cahyaningratri Amina Jasmine , Putri Malfa Liya , Devi Priesta Mayestika Karunia , Ariyanto Renaldi Jafras , Hikmah Syafaqoh Mahdiyatul
Published: June 2024

Industri batik ecoprint adalah salah satu sektor usaha yang mengalami pertumbuhan ekonomi, terutama karena penggunaan teknik pewarnaan alami yang ramah lingkungan. Omah Ecoprint merupakan usaha kreatif Ibu PKK RW 4 Perumahan ITS yang berjalan hampir 3 tahun. Selama ini proses produksi dilakukan secara manual. Proses manual ini menyebabkan keluhan fisik yang mempengaruhi keselamatan dan kesehatan kerja. Oleh karena itu pengabdian masyarakat ini akan melakukan identifikasi potensi bahaya proses produksi batik ecoprint. Metode Hazard Identification, Risk Assessment, and Risk Control (HIRARC) digunakan untuk mengidentifikasi dan menilai risiko bahaya ergonomi dan keselamatan dan kesehatan kerja (K3). Hasil identifikasi bahaya menunjukkan 21 bahaya yaitu 7 bahaya ergonomi, 6 bahaya K3, 5 bahaya kimia, 2 bahaya kebakaran dan 1 bahaya uap panas. Hasil penilaian risiko menunjukkan 14 medium risk dan 7 high risk. Aktivitas kerja yang memiliki risiko tinggi adalah penempatan corak ke kain, penggilingan kain dengan roller cor semen, penggulungan dan pengikatan kain, dan pengukusan kain. Tindakan kontrol mengikuti hirarki penanganan risiko dan diutamakan pada risiko tinggi. Rekomendasi yang diberikan adalah substitusi penggunaan bahan kimia yang ramah lingkungan, \textit{engineering} dengan desain meja kerja yang ergonomis, administrasi pembutan SOP pelaksanaan kerja dan APD menggunakan alat pelindung diri yang sesuai (masker, sarung tangan dan alas kaki).
Peran Suplai Daging dalam Sertifikasi Halal Self Declare pada Percepatan Pemulihan Ekonomi di Kelurahan Bulak-Surabaya
Authors: Gunawan Setiyo , Juwari Juwari , Aparamarta Hakun Wirawasista , Wiguno Annas , Anugraha Rendra Panca , Puspitawaty Penny Diana , Prabowo Ari
Published: June 2024

Tujuan dari pengabdian masyarakat (Abmas) ini adalah mempelajari peran suplai daging segar dalam kesuksesan pendampingan fasilitasi sertifikasi halal dengan pernyataan pelaku usaha (self declare), yang merupakan salah satu cara yang diharapkan mampu mempercepat pemulihan ekonomi di Kelurahan Bulak, Kota Surabaya. Pelaksanaan kegiatan ini dibagi menjadi 6 tahapan, yaitu seleksi pelaku usaha mikro dan kecil, seleksi mahasiswa kuliah kerja nyata (KKN), workshop kader penggerak halal, pendampingan penyusunan dokumen manual Sistem Jaminan Produk Halal (SJPH), pendaftaran sertifikasi halal, dan pemberian plakat logo binaan pusat kajian halal Institut Teknologi Sepuluh Nopember (ITS). Dalam kaitannya dengan bahan yang digunakan harus dipastikan kehalalannya, para pelaku usaha mengalami kesulitan menemukan daging segar halal bersertifikat halal di pasar. Hal ini mengakibatkan sekitar 53% pelaku usaha tidak bisa menikmati program sertifikasi halal gratis 2023. Tempat potong hewan tradisonal yang ada dipasar ternyata tidak ada ijinnya. Kendala kebijakan pemerintah lainnya, yaitu limbah yang sesuai dengan Analisis Mengenai Dampak Lingkungan (AMDAL). Tempat potong hewan tradisonal bisa menjadi sumber kontaminasi penyakit karena kemungkinan ternak yang dibawa untuk dipotong berasal dari suatu daerah yang sedang ada dalam keadaan infeksi subklinis suatu penyakit. Sedangkan, kewenangan untuk mengatur tempat potong hewan tradisonal agar bisa menjadi dan memenuhi standard Rumah Potong Hewan (RPH) ada di pemerintah kabupaten/kota.
Pengembangan Website Sekolah sebagai Sarana Pendukung Pembelajaran: Studi Kasus MTS I’anatut Tholibin Lamongan
Authors: Widianto Muhammad Y. H. , Darmaji Darmaji , Sulistyaningrum Dwi Ratna , Setiyono Budi , Sanjoyo Bandung Arry , Utomo Daryono Budi
Published: June 2024

Website sekolah merupakan gerbang utama untuk mengetahui berita penting, profil sekolah, guru-guru yang mengajar dan info-info terbaru. Website dapat juga digunakan untuk mendukung kegiatan belajar mengajar di sekolah. Disini kami mengambil studi kasus pada MTS I’anatut Tholibi Lamongan yang belum mempunyai website sekolah. Pertama, kami melakukan kajian website yang cocok untuk dikembangkan pada sekolah tersebut. Kami mendapatkan kajian yang berupa: 1. Sekolah belum mempunyai website sama sekali, 2. Guru-guru dan tendik belum terbiasa menggunakan media website sebagai pendukung kegiatan belajar mengajar, 3. Konten yang akan diunggah di website sekolah harus diatur sedemikian sehingga dapat menunjang pembelajaran. Alamat domain sekolah telah dibuat dan dapat diakses melalui www.ianatuttholibin.sch.id. Kegiatan pelatihan juga dilakukan untuk meningkatkan kompetensi guru-guru dalam mengembangkan kegiatan belajar mengajar melalui website. Konten-konten terkait pembelajaran dapat diakses oleh siswa melalui website sekolah. Hasil dari pengabdian masyarakat ini adalah website sekolah, publikasi media massa, jurnal nasional dan juga video cipta.
Global progress and Never Events
Authors: Tingle John
Published: June 2024

John Tingle, Lecturer in Law, Birmingham Law School, University of Birmingham, discusses some national and international reports on patient safety
A clinical observational case series evaluation of a superabsorbent dressing on exudating wounds
Authors: Collier Mark
Published: June 2024

The annual cost to the NHS of managing 3.8 million patients with a wound was estimated in 2020 to be £8.3 billion, of which £5.6 billion was spent on the 30% of wounds that did not heal and £2.7 billion on the 70% of wounds that healed ( Guest, 2020 ). One of the main symptoms associated with chronic ‘hard-to-heal’ wounds is the production of excess exudate ( Atkin et al, 2019 ). This is due to a prolonged chronic inflammatory response stimulated by a physiological cause. This article describes what exudate is and its importance in the wound healing process, highlighting the consequences of too little or excessive wound exudate associated with any wound. The article goes on to describe a case series observational study involving a range of patients (n=47; 33 male/14 female), aged between 33 and 91 years (mean 67.4 years), with a variety of acute (n=11) and chronic exuding wounds (n=44). In total, 55 wounds of various aetiologies were managed with DryMax Super (a dressing whose design includes superabsorbent polymers) in order to evaluate and report on the absorption and fluid-handling properties of the product.
A screening assay based on PCR amplification of Cytochrome b for species identification of some animals in Cervus
Authors:   Department of Integrated Science, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand, Surapak Preedaporn , Chaisongkram Chavin ,   Khon Kaen Zoo, Zoological Park Organization, Khon Kaen 40000, Thailand, Lomthaisong Khemika ,   Department of Integrated Science, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand
Published: June 2024

Sambar deer (Cervus unicolor) is a protective animal in Thailand. Sambar deer meat has become popular among consumer. Therefore, the smuggling of sambar deer has increased. For the success of prosecution, species identification of meat origin is necessary. An easy-to-perform screening assay for species identification of sambar deer meat is described in this study. The detection of three species of cervids including sambar deer, sika deer (Cervus nippon) and rusa deer (Cervus timorensi) was achieved by using newly designed primers targeting sambar deer cytochrome b (Cyt b) region producing an amplicon of approximately 350 base pairs (bp). The possibility of cross-amplification was prevented by testing with other species of cervids including eld’s deer (Cervus eldi), muntjac (Muntiacus spp.), chital deer (Cervus axis), hog deer (Axis porcinus) and popular consumed meats (pork, beef, chicken, seabass). The limit of detection (LOD) on sambar deer DNA was 31.25 pg. Sensitivity of detection of possible sambar deer in mixed meat species was 2%. Suitability of the screening assay was confirmed on processed meats like frozen meats (-20 oC, -80 oC) and cooked meats including boiled, steamed, autoclaved, fried, microwave cooked and grilled. Hence, this screening assay can effectively be used for preliminary examination of sambar deer origin in questioned evidence.
The antibiotic susceptibility of Aeromonas schubertii isolated from snakehead in An Giang province of the Mekong Delta
Authors:   Faculty of Applied Biological Sciences, Vinh Long University of Technology Education, Vinh Long City 89000, Vietnam, Thi Quach Van Cao , Trung Nguyen Bao ,   College of Aquaculture and Fisheries, Can Tho University, Can Tho City 90000, Vietnam, Dung Tu Thanh ,   College of Aquaculture and Fisheries, Can Tho University, Can Tho City 90000, Vietnam, Thuy Nguyen Phuong ,   School of Agriculture and Aquaculture, Tra Vinh University, Tra Vinh City 87000, Vietnam
Published: June 2024

Antibiotic resistance and the transmission of resistance genes among bacteria in aquaculture are attracting world attention. The investigation was conducted to evaluate the antibiotic susceptibility of Aeromonas schubertii, which causes intensively cultured internal white spot disease in snakehead from An Giang province of the Mekong Delta. The findings isolated 29 bacterial strains from the kidney, spleen, and liver of diseased snakehead fish. Based on the morphological, biochemical, and 16S rRNA gene sequencing results, two strains of As9 and As11 showed a similarity of 98.71 % and 97.07 % to A. schubertii strains ZL-1 and GZ210812, respectively. The disc diffusion method was used to conduct antibiograms of the strains for 12 antibiotics. The research indicated that the bacteria were susceptible to the antibiotics ceftazidime, cefalexin, and doxycycline at rates of 86 %, 59 %, and 55 %, respectively. Meanwhile, bacteria were highly resistant to amoxicillin (93 %), flumequine (83 %), ciprofloxacin (76 %), rifampicin (66 %), erythromycin (62 %), colistin (59 %), florfenicol (59 %), and novobiocin (41 %). Interestingly, 100 % of the bacterial strains in the study demonstrated a multidrug-resistant phenotype, resistant to at least two antibiotics or more.
Effects of the fermented soya waste supplementation with various probiotic sources on growth performance of crossbred rabbits
Authors:   Faculty of Animal Sciences, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Truong Trung Thanh , Tran Hai Long ,   Faculty of Animal Sciences, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Nguyen Nghia Khoi ,   Faculty of Soil Sciences, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam, Nguyen Tam Thu ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Vietnam
Published: June 2024

The experiment on the growth of rabbits involved a completely randomized design with six treatments and six replications, with two rabbits with balanced sexual distribution per trial unit. The six treatments included different methods of treating soya waste, including cooking it (T1), and five commercial probiotics, namely the biotic probiotic (T2), garlic powder probiotic (T3), M-VS05 probiotic (T4), UV-Bacillus probiotic (T5), and the alive probiotic (T6). The soya waste was anaerobically fermentedin three days before feeding it to the experimental rabbits. The results showed that the use of probiotic treatments improved nutrient intake, nutrient digestibility, digestible nutrients, and nitrogen retention (P>0.05). The T3 treatment resulted in the highest daily weight gain (P<0.05) and economic returns for the experimental rabbits. There were no significant differences in the physiological and biochemical indicators of rabbit blood between treatments (P>0.05). The group of rabbits fed with T1 treatment (without probiotics) had a much higher density of E. coli in their fecesthan the other five groups. These findings indicated that treating anti-nutrients in soya waste with probiotics could replace heat treatment and result in better growth performance, improved daily weight gain, and increased profits for growing rabbits.
Genetic characterization of canine distemper virus from infected dogs in Can Tho City, Mekong Delta, Vietnam
Authors:   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Viet Nam, Thao Tran Thi , Thuan Nguyen Khanh ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Viet Nam, Tham Dang Thi ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Viet Nam, Tienv Van My ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Viet Nam, My Tu Dang Thi ,   Faculty of Veterinary Medicine, College of Agriculture, Can Tho University, Can Tho 900000, Viet Nam
Published: June 2024

The study aimed to evaluate the endemicity and determine the genetic characteristics of canine distemper virus (CDV) in Can Tho City. A study was carried out on 1,120 dogs raised in Can Tho City, and there were 150 dogs showed clinical signs of canine distemper. The result showed 68/150 (45.33%) dogs were positive for CDV, which was determined based on the test kit of Rapid Test Immumo provided by Asan company (Korea). Dogs under 6 months-age had the highest infection rate (68.00%), significantly higher than other age groups (P<0.05). Male dogs (50%) were more affected than females (41.86%). Exotic dogs showed a higher CDV infection rate compared to domestic dogs, with statistical significance (P<0.05). All dogs displayed clinical signs such as anorectic, moodiness, fever, sneezing, and eye conjunctivitis. Vaccinated dogs had a lower infection rate (6.25%) compared to unvaccinated or under-vaccinated dogs (80% and 69.57% respectively). The study on genetic characteristics of 7 representative Distemper virus strains isolated from the infected dogs was conducted via sequencing the H gene. Genetic analysis of seven representative CDV strains revealed a high similarity (99.82-99.96%) among isolated strains, indicating a common origin and frequent circulation in the study area. Nucleotide similarity with strains in the GenBank ranged from 93.26% to 99.56%, and with vaccine strains from 96.72% to 97.08%. The isolated CDV strains belonged to the Asia 1 lineage, commonly found in Vietnam and other Asian countries.
Stefnugeta í íslenska stjórnkerfinu
Authors: Matthíasson Pétur Berg
Published: June 2024

Eftir fjármálahrunið kom berlega í ljós að stefnumótun og áætlanagerð hefði verið ábótavant í aðdraganda þess. Í skýrslu Rannsóknarnefndar Alþingis (2010) og síðar í skýrslunni Samhent stjórnsýsla (2010) voru ýmsar hugmyndir reifaðar um hvernig styrkja mætti stefnugetu (e. policy capacity) innan Stjórnarráðsins. Ráðist var í umfangsmikla endurskoðun á skipulagi, verklagi og vinnubrögðum innan stjórnsýslunnar. Í þessari grein er gerð tilraun til að meta stefnugetu í ráðuneytum með hliðsjón af líkani sem þróað var af fræðimönnunum Wu, Ramesh og Howlett (2015). Unnið er með niðurstöður úr könnunum á vegum stefnuráðs Stjórnarráðsins yfir 6 ára tímabil, frá 2015-2021. Við mat á stefnugetu er stuðst við spurningar í könnununum sem höfðu sterka samsvörun við líkan Wu og félaga, er lutu að greiningarhæfni, samstarfi, stuðningi stjórnmálamanna, fjármögnun, samhæfingu þvert á aðrar stofnanir o.fl. Þegar framangreindir þættir eru skoðaðar með hliðsjón af líkaninu kemur í ljós að það er þó nokkur stefnugeta í kerfinu, sérstaklega greiningarhæfni en það eru áskoranir er snúa að framkvæmdaþættinum. Niðurstöður benda einnig til þess að gagnlegt geti verið að styðjast við líkön til að meta stefnugetu. Aftur á móti eru ýmsir annmarkar sem gera það að verkum að erfitt getur verið að fá heildarmat á stefnugetu innan Stjórnarráðsins.
Skilvirkara stúdentspróf eftir styttingu? Reynsla háskólanema og háskólakennara af stefnubreytingum á framhaldsskólastiginu
Authors: Ragnarsdóttir Guðrún , Bjarnadóttir Valgerður S. , Jónasdóttir María
Published: June 2024

Umfangsmiklar stefnubreytingar, sem eiga rætur sínar að rekja til hugmynda um kosti dreifstýringar, alþjóðlegs samanburðar og aukinnar skilvirkni í menntakerfinu, voru gerðar á framhaldsskólastiginu á árunum 2008–2015. Framhaldsskólum var gert að endurskoða skólanámskrár og loks kom tilskipun frá ráðherra um að stytta námsleiðir til stúdentsprófs um eitt ár. Markmið rannsóknarinnar er að varpa ljósi á sjónarhorn nemenda og kennara í Háskóla Íslands um undirbúning framhaldsskólans fyrir nám á háskólastigi í ljósi þessara breytinga. Greinin byggir á viðtalsgögnum frá tíu háskólanemum sem brautskráðust frá ólíkum framhaldsskólum úr þriggja ára kerfinu og sextán reyndum háskólakennurum. Niðurstöðurnar gefa til kynna ákveðna togstreitu milli breiddar og sérhæfingar stúdentsprófsins, og valfrelsis nemenda samfara niðurskurði og þéttingu námsins. Viðmælendur töldu að stúdentsprófið veitti ekki sama undirbúning og áður og ræddu gildi og virði þess. Háskólakennarar af Verkfræði- og náttúruvísindasviði höfðu áhyggjur af auknum skólamun eftir styttingu. Niðurstöðurnar vekja upp áleitnar spurningar um félagslegt réttlæti og hvort allir framhaldsskólar veiti nemendum jöfn tækifæri til áframhaldandi náms á háskólastigi. Einnig eru niðurstöðurnar innlegg í áframhaldandi umræðu um og rannsóknir á styttingu námstíma til stúdentsprófs og hlutverki framhaldsskólans í íslensku skólakerfi.
The man with a plan: a genealogical study of the medicalisation and individualisation of the 2004 Norwegian drug treatment reforms
Authors: Johansen Kenneth Arctander , Feryn Nele , Vandevelde Stijn , Vandenbroeck Michel
Published: June 2024

This article explores the implications of the 2004 Norwegian substance treatment reforms for social work. It considers power dynamics in social, political and economic contexts. The reforms aimed to address the absence of consensus and oversight in the Norwegian drug treatment system and to enhance accessibility and individualised care for people with substance use disorders. Using a genealogical approach and a theoretical framework based on Michel Foucault’s concept of biopower, this study analyses the integration of control and welfare policies to combat drugs and the reform’s emphasis on self-governance, alongside management considerations. The findings reveal a shift in governmentality regarding addiction services in Norway, towards neoliberal management and an emphasis on local governeance, decentralisation and invidualised care. Moreover, the study highlights the potential for undesirable biopolitics to emerge, particularly in the context of the simultaneous coercion and treatment of people using illegal drugs. The study concludes by discussing the implications for social work practice and calling for further research on the integration of control and welfare policies.
Preparation and properties of tellurite glass-based CsPb(BrCl)3@glass fluorescent film for a white light emitting diode color converter
Authors: Li Bo , He Ziyu , Zhao Guoying , Qiao Xin , Wang Zhongzhi , Fang Yongzheng , Shi Liqun
Published: June 2024

Perovskite nanocrystal glass has the advantages of narrow-band emission, easy tuning, and stable structural, physical, and chemical properties, and can be used to mix with other colored materials for white light modulation. The current white light mode widely adopts the packaging method of blue light chip and yellow phosphor, which has the problem of a blue-yellow cavity and low light quality. In this work, the central wavelength of CsPb(BrCl)3 can be adjusted continuously ranging from 463 nm to 486 nm by adjusting the relative ratio of bromine to chlorine in nanocrystals. On the basis of the previous design of YAG:Ce phosphor-in-glass, perovskite nanocrystal glass powder as a color compensator was introduced into the tellurite glass matrix to form a doubly encapsulated system by low-temperature co-sintering. The yellow phosphor and perovskite nanocrystal glass maintain good structural integrity in the glass matrix. By combining the double-package fluorescent material with the blue chip, the continuous adjustment of chromaticity coordinates along the saddle line is realized, and the color-rendering index is also improved to 81.3.