bluuebunny/crossref_metadata_2025 huggingface dataset:
The Association Between Nutritional Status and Anemia in Adolescent Girls in Kupang City: A Cross-Sectional Study
Authors: Monika Azi Djogo Herliana , Letor Yulia M.K
Published: February 2022

Anemia among adolescent females is a leading worldwide public health problem that should be given appropriate attention. Adolescent females are one of the major risk groups for anemia. This study aimed to determine the association between nutritional status and anemia in adolescent girls in Kupang City. A cross-sectional study design was employed. This research was conducted from July to August 2021 in Kupang City. Purposive sampling was used and 256 adolescent girls participated. A structured questionnaire was used to collect the data. The hemoglobin level and anthropometry measures were taken to determine the anemic and nutritional status of the females based on World Health Organization guidelines. Chi-square tests were used to analyze the data. The incidence of anemia among the adolescent girls was 64.5%, while 31% of the girls were underweight. The results showed that there was no significant relationship between nutritional status and anemia among adolescent girls in Kupang city (p = 0.06). The notably high prevalence of anemia found in the adolescent girls was correlated with other health and wellness concerns. Anemia and undernutrition negatively affect academic performance, productivity, and general wellbeing of adolescents. The findings provide helpful information for nurses to initiate effective health promotion and prevention programs for adolescent nutritional status and anemia in the community.
Keywords: anemia, adolescent, females, nutritional status
Implementation of Internet-Based Technology in Primary Health Care During the COVID-19 Pandemic
Authors: Lindayani Linlin , Mutiar Astri , Permana Bhakti
Published: February 2022

Primary health care services in Indonesia are facing challenges in dealing with the COVID-19 pandemic. Many primary health services are limited as a result of the lockdown policy, which can prevent people who are experiencing health difficulties from seeking assistance. This study aimed to examine the implementation of internet based technology in the primary health care sector for COVID-19 prevention. An experimental two-group pretest-posttest design was used. Respondents were offered an intervention in the form of internet-based instruction in five sessions (each meeting lasting 45 minutes) over three weeks; these sessions involved talks with PowerPoint presentations and applications regarding COVID-19 prevention. The level of knowledge about COVID-19 prevention grew considerably between the pre- and post-intervention periods, from 3.02 (SD = 1.25) to 4.45 (SD = 1.31), with a p-value < 0.001, while there was no significant decline in the control group (p = 0.260). Health monitoring systems are used to examine data gathered over the course of implementing a health program for patients. The implementation of this program resulted in an increase in the knowledge and abilities of health workers regarding the use of technology. Training to boost health workers’ capacity for technology use is urgently needed and should be implemented across all facility health workers.
Keywords: internet of things, primary health care, COVID-19
Perceptions of Indonesian Nurses Toward the Application of the Internet of Things in the Future
Authors: Taryudi Taryudi , Lindayani Linlin , Mutiar Astri , Purnama Heni
Published: February 2022

In the healthcare industry, Internet of Things (IoT) based systems are utilized for phone care delivery, smart healthcare, smart health sensors and wearable technology, preventative systems, and distant monitoring. No studies have assessed nurses’ perspectives of IoT applications in Indonesia. The purpose of this study was to identify health professionals’ perspectives on future health and technology trends, to identify their readiness to adopt new health technologies, and to identify the use of IoT technology in healthcare applications. This study was conducted using a descriptive and cross-sectional approach. Nurses with a Diploma III and at least one year of experience were selected from three different departments (medical surgical, pediatrics, maternity). About 76% of 350 nurses had little knowledge of IoT technology and 95% said they do not keep up to date with IoT publications. About 50% of nurses believed that IoT technology will have a large impact on the health and education sectors. These results indicated that IoT technology and informatics should be included in nursing education and further studies should be conducted to integrate technological trends into healthcare and nursing practices.
Keywords: perceptions, nurses, internet of things, healthcare
INVESTIGATION OF VIBRATIONS OF A BEAM MADE OF A FUNCTIONALLY GRADED MATERIAL TAKING INTO ACCOUNT ATTENUATION
Authors: Vatulyan Alexander O. , Varchenko Anastasiya A.
Published: February 2022

The problem of oscillations of an inhomogeneous beam made of a functionally gradient material in the framework of various deformation models - the Euler-Bernoulli model and the Timoshenko model in the presence of attenuation, which is described within the framework of the concept of complex modules for a standard viscoelastic body, is considered. The left end of the beam is pinched, and at the right end there is a concentrated moment oscillating with a certain frequency. The solution is built in two ways. In the first of them, on the basis of asymptotic analysis, a solution was constructed in the low-frequency domain, and a complete coincidence of solutions for the models under consideration in the low-frequency domain (up to the first resonance) for any laws of inhomogeneity was shown. In the second case, the influence of rheological factors on the amplitude-frequency characteristics of an inhomogeneous viscoelastic beam in the frequency range up to the third resonance was analyzed using the targeting method. A comparative analysis of the frequency response of two models for different laws of heterogeneity is carried out. Frequency response for various laws of inhomogeneity are presented, the movement of resonant frequencies depending on the dimensionless relaxation time is studied.
Notas botánicas sobre aislamiento y contacto. Plantas y vestigios hi-merimã (río Purús/ Amazonía brasileña)
Authors: Cangussu Daniel , Shiratori Karen , Furquim Laura
Published: February 2022

Con el fin de restaurar, aunque parcialmente, la memoria de las intensas relaciones que existían entre los distintos pueblos arawá de la región del medio curso del río Purus, este artículo aborda, a través del entrelazamiento de la vida humana y la vegetal, la socialidad que acabó rompiéndose, las historias que algún día se compartieron, pero también los vínculos que aún reverdecen en los bosques. La ciencia matera, atenta a las plantas y a los vestigios antrópicos presentes en los bosques, muestra caminos insospechados  para analizar las complejas relaciones entre los hi-merimã, actualmente aislados, y sus vecinos, especialmente los jamamadi. En este texto, proponemos un análisis del relato de un encuentro a través de notas que demuestran la centralidad y fecundidad de las plantas para la comprensión de la sociabilidad y la dinámica territorial mi-merimã. Las notas se basan en datos bibliográficos oriundos de estudios antropológicos, arqueológicos y botánicos, así como en información obtenida de los pueblos indígenas y de los habitantes ribereños de la zona.
Collaborative learning of differential equations by numerical simulation
Authors: López-Reyes Luis Javier
Published: February 2022

This paper presents a didactic proposal designed through the active methodology of Collaborative Learning to analyse the effect of the use of numerical simulation of a mathematical model on the learning of differential equations in engineering students. A mathematical model of a vibrating string was used, and the Octave Online platform was used for the numerical simulation. The analysis and assessment of this proposal was carried out in a hybrid, quantitative and qualitative manner, through the design of observation and measurement instruments. The results indicate that in STEM programs, the use of numerical simulation in a collaborative learning environment strengthens student learning and fosters the development of disciplinary and soft skills.  

 

Keywords: Collaborative Learning; Differential Equations; Mathematics Education; Numerical Simulation; STEM Skills.
Formation of professional competencies of a future foreign language teacher in the field of distance education
Authors: Aida Shakiyeva , Ainur Zhorabekova , Ardak Alipbek , Madina Akeshova , Perizat Kudabayeva , Gulnara Rizakhojayeva
Published: February 2022

The aim of this study is to evaluate the opinions of teacher candidates and teachers related to foreign language teaching through distance education and to make forward-looking recommendations in line with these views. The study group consists of 30 teacher candidates who studied foreign language teaching at various universities in Kazakhstan during the 2020–2021 academic year and 35 English teachers who teach English in secondary schools in Almaty. The study was carried out within the scope of qualitative research and research data were collected with two semi-structured interview forms created by the researcher. The data obtained from the research are categorised by content analysis. As a result of the study, teacher candidates found distance education more inefficient in education than formal education and inadequate to provide distance education. Teachers, on the other hand, saw distance education as advantageous in terms of saving time and space, disadvantaged by student motivation, teacher inexperience and technical glitches. As a result of the research, it has emerged that urgent solutions are needed to eliminate the need to provide a separate education on distance education to teacher candidates and teachers, student motivation and technical problems.

Keywords: distance education, advantages of distance education, disadvantages of distance education, foreign language teacher candidates, foreign language teachers, teacher opinions
Manajemen Mutu Pengembangan Lembaga Pendidikan Islam
Authors: Yaqien Nurul
Published: February 2022

The existence of a good quality institution is required to afford good quality and professional human resources (HR) services. This need will not be achieved unless through a good quality educational institution. It is expected that the result of a good quality education process will be able to produce competitive human resources nationally, regionally, and globally. Among the several good quality Islamic institutions, SMA Al-Izza Batu and SMA Darul Ulum 2 Jombang are very well known. Both are Islamic educational institutions that are organized using national and international standard quality. The indicators of a good quality Islamic education institution can be seen from the academic or non-academicals achievements and the grade of the accreditation at the national or international level. The researcher wants to analyze the success achieved by the two institutions as an attempt to develop Islamic institutions in Indonesia.
The Interactive Effect of Anxiety Sensitivity and Metacognitive Beliefs on Anxiety
Authors: Gorday Julia Y. , Bardeen Joseph R.
Published: February 2022

Anxiety sensitivity (AS) has been identified as a contributing factor to the development and maintenance of anxiety. Individuals with high AS are sensitive to bodily cues and anxiety-related thoughts and often misinterpret these stimuli as catastrophic or dangerous. Similarly, negative and positive metacognitive beliefs (i.e., beliefs about thinking) are believed to increase internal threat monitoring and the use of maladaptive coping strategies, which may increase the impact of AS on anxiety. As such, the purpose of the present study was to examine the moderating role of metacognitive beliefs on the relationship between anxiety sensitivity and anxiety. Adult participants (N = 417), recruited through an online crowdsourcing website, completed a battery of measures assessing the constructs of interest. Results from multiple linear regression indicated that the relationship between AS and anxiety became significantly stronger as negative and positive metacognitive beliefs increased, thus suggesting that negative and positive metacognitive beliefs may exacerbate the effect of AS on anxiety. The development of risk profiles that incorporate AS and negative and positive metacognitive beliefs may be beneficial for early identification of individuals at high risk for the development of anxiety.
Musykilâtul al-Mudarris fî Tashmîmi Tadrîs al-Lughah al-'Arabiyah fî al-Shaffi al-Tâsnî min Madrasati al-Falâh al-'Âliyah al-Islâmiyah Sumber Gayam Kadur
Authors: Taufikurrahman Raden , Aliyah Unayyizaturrafiatul
Published: February 2022

This study answers two main questions, about what problems are faced by teachers in designing Arabic language learning in class 2 MA Sumber Gayam Kadur along with the solution. The researcher used qualitative methods and analytical descriptive studies. Then, the data sources for this study included Arabic language teachers, a number of class 2 students, and the school principal of MA Sumber Gayam Kadur. All data presented in this study came from structured and unstructured interviews, observations, and documentation. This research proves that the problems faced by teachers include the selection of the best methods that are most suitable for students who are not homogeneous, time management that must be managed properly, and problems related to the application of learning steps that are appropriate to the classroom conditions. From all of these problems, the researcher can conclude the solution by presenting at least 2 experts to update the curriculum every year, encouraging teachers to be active in training organized by the local government and the Foundation's full support in improving the quality of teachers.
Tathbîq Tiknûlûjiyâ (Istirâtîjiyah al-Kharîthah al-Dzihniyah) li Hilli Musykilah Ta'lîm Mufradât al-Lughah al-'Arabiyah Lada Thullâb al-Fashl al-Sâbi' fî al-Madrasah al-Tsânawiyah "Nurul Jadid Banyuputih - Situbondo"
Authors: Fu’adah Shofwatul
Published: February 2022

The inhibiting factor for students having difficulty in learning Arabic is that vocabulary mastery is still very limited, even though the vocabulary is an elementary language that must be mastered by foreign language learners including the Arabic Language. Therefore learning methods and strategies are very influential in the learning process and student's motivation to study. Learning strategies included in the design of domain learning technology. So the teacher in this school uses mind mapping strategies to solve the student's problem in mastering Arabic vocabulary. In this study, the researcher used a qualitative method. While the process, the researcher has a source of data from the mufradat/vocabulary learning process as well as the students involved in it. This paper discusses the implementation of learning technology (mind mapping strategy) to solve the problem of learning mufradat. And The results of this study prove that the mind mapping strategy help to improve mufradat mastery of the students and them following the learning process with pleasure.
Tanmiyah Mahârah al-Kalâm bi Tathbîqi at-Tharîqah al-Ittishâliyyah: al-Bahts at-Tanfîdziy fî al-Fiah ad-Dirâsiyyah
Authors: Amrullah Afif
Published: February 2022

This research was intended to improve student's speaking ability by applying communicative method, and at the same time, to find out the effectiveness of using this teaching method in promoting speaking skills. The problem with this research was formulated interrogatively as follows: Is the implementation of communicative methods capable of improving the speaking skills of eighth grade students at National Islamic Junior School, Bandar Lampung? This research can be categorized as Classroom Action Research, and as subject research. They are all eight grade students at National Islamic Junior School Bandar Lampung. To obtain data, this research used several methods: observation, interview, documentation, and testing. This research is qualitative research, and the data was analyzed in three steps: data reduction, data display, and then interpretation. This research results in the following conclusions: In first session, the students who passed the test 54.40% and who failed 45.59%, in second session, students who passed the test 86.64%, and who failed 13.35%, and in the third session the students who passed test 78.83%, and who failed 21.16%, than can be concluded that implementing a communicative method in teaching Arabic as a second language is capable of improving speaking skills.
Kohesi Leksikal Dalam Surah Al-Kahfi: Kajian Analisis Wacana
Authors: Nita Zakiah
Published: February 2022

Research on lexical cohesion in surah Al Kahfi aims to be known lexical relationship between parts of the text to get cohesive structural compatibility, in terms of words in the Qur'anic verse, or between verses with other verses. The study of lexical cohesion in surah Al-Kahfi used a descriptive qualitative approach. The data collection technique used was library research to obtain data. The method used in the data analysis stage was the distributional method. Lexical cohesion in Surah Al Kahfi was proven by reiteration and collocation. Reiteration is repeating the words in the next sentence to give emphasize that the word is the object. The results of this research are that Reiteration in surah Al Kahfi in the verses 32-33 and verse 51, a synonym in the verses 30-31 and verse 54, hyponym in the verses 34-35, verses 50 and 54, metonym in the verses 9-10, and the antonym in the verses 18, 63, and 17. Collocation is based on the relationship between the words in common the fact that frequently occurs around it, or link meaning between a single word in other words in the same context, such as in verses 17 and 29
Evaluación multiperspectiva de las palmas de Sabal y otras plantas posiblemente utilizadas como material para techos por los antiguos mayas en las tierras bajas centrales
Authors:   Bonn Center for Dependency and Slavery Studies, Germany, Graf Paul
Published: February 2022

The Maya vernacular house of the pre-Columbian era has been little studied so far and new methodological approaches are needed to reconstruct its architectural and material characteristics. Particularly for the roof, there is a lack of any studies that would verify the speculative descriptions in the literature. Using a multi-perspective approach that includes ecological, paleoecological, archaeological, ethnohistorical, ethnobotanical and ethnolinguistic perspectives, this article aims to evaluate the palm species of the genus Sabal, known as the guano palm or xa'an, as the most important resource for roof construction in the Maya lowlands. Based on data from my own geoethnobotanical and ethnoarchaeological field work, paleoecological data from drilling cores and research results from other studies, it is demonstrated that a forest species of the genus Sabal was probably the primary thatching material for the Classic population of the central Maya lowlands.
Determinantes sociales y culturales y estrategias en salud en la atención médica especializada a población maya con VIH en Chiapas
Authors:   Centro de Investigación y Estudios Superiores en Antropología Social. CIESAS, Mexico, Muñoz Martínez Rubén
Published: February 2022

The article analyzes social and cultural determinants that impact on access, adherence and timely follow-up of antiretroviral treatment of the Tseltal and Chol population with HIV in Chiapas and strategies of care and accessibility to treatment of support networks and health personnel. It contributes to the scarce existing research on non-adherence to antiretroviral treatment among indigenous peoples in Mexico and Latin America. The methodology is qualitative, based on a case study in an HIV care clinic (SAIH), during the period 2017-2018, with health personnel, users and family members, and is complemented with descriptive quantitative data on mortality and differential vertical transmission. The results demonstrate the impact on this population of the centralization of treatment in the SAIH, ofthe economic difficulties for travel, of the stigma and discrimination existing in their communities, and of the organizational culture of the SAIH. Strategies regarding care and/or pluralism of care are also identified. It is urgent to generate knowledge and specific measures from public policies and their implementation.
Rapid UV-Vis spectroscopy methods for quantification of ranitidine tablets
Authors: Rijo Patrícia , Ribeiro Lara , Nicolai Marisa , Pereira Paula , Faustino Célia
Published: February 2022

Ranitidine is a histamine H2-receptor antagonist that inhibits gastric acid secretion, commonly used in the treatment and prophylaxis of peptic ulcer and gastroesophageal reflux disease. Over-the-counter ranitidine hydrochloride tablets are available in several European countries as well as the US for the relief of indigestion and heartburn. Commercial tablets containing the equivalent of 150 mg of ranitidine were analysed following extraction. Ranitidine is water-soluble, thus avoiding the use of organic solvents. Standard aqueous solutions of ranitidine hydrochloride were used to construct a calibration curve. This graduate laboratory experiment describes a simple, inexpensive, safe, and “green” procedure for the quantification of ranitidine tablets by UV spectrophotometry. The entire procedure provides an pedagogical opportunity to approach a realistic analytical scenario, typical of a quality control laboratory, by designing an attractive and engaging hands-on session. An average content of 148 ± 1 mg of ranitidine was determined using both standard addition and external calibration methods and results are in agreement with Pharmacopoeia. Keywords: Analytical chemistry, ranitidine, drugs/pharmaceuticals, quantitative analysis, UV-Vis spectroscopy
Clinical efficacy of a cosmetic formulation with vitamin B3 for the treatment of oily skin
Authors: Gabarra Almeida Leite Marcella , Berardo Gonçalves Maia Campos Patrícia Maria
Published: February 2022

Oily skin has special needs, as the treatment and prevention of non-inflammatory acne and sebum control, maintaining skin barrier function and hydration. In this context, the importance of the development of specific and innovative cosmetics formulations to to fulfill the needs of this type of skin is evident. In this view, the aim of this study was the evaluation of the clinical efficacy of a cosmetic formulation containing Vitamin B3 in the treatment of oily skin using biophysical and skin imaging techniques. Female volunteers (n=40) between 18 to 30 years old with oily skin and/or mild inflammatory acne were recruited and received a formulation containing, or not (vehicle), 3% of Vitamin B3. Stratum corneum water content, transepidermal water loss (TEWL), sebum content and quantity of porphyrins were analyzed before (baseline) and after 28 days of application. Finally, an efficacy perception questionnaire was applied at the study end. The formulation with vitamin B3, showed a significant reduction of sebum and porphyrin content. The study participants in the assessment of perceived efficacy also reported these results. The studied formulation with Vitamin B3 was effective for oily skin care, acting on important parameters, such as controlling oiliness and improving skin appearance. Keywords: cosmetics, Niacinamide, skin physiology, oily skin, biophysical and skin imaging
Silvia Soriano Moreno (coord.). Perspectivas jurídicas de la igualdad de género en el entorno rural
Authors: Martín Guardado Sergio
Published: February 2022

Este artículo reseña: Silvia Soriano Moreno (coord.). Perspectivas jurídicas de la igualdad de género en el entorno rural. Navarra: Cizur Menor, Thomson Reuters-Aranzadi, 2021.
SYNTHESIS OF BACTERICIDAL MICROFILTRATION CERAMIC MEMBRANES
Authors:   Faculty of Chemical Technology, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine, O. Serhiienko Alla , A. Dontsova Tetiana ,   Faculty of Chemical Technology, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine, I. Vorobyova Victoria ,   Faculty of Chemical Technology, National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute”, Kyiv, Ukraine
Published: February 2022

Membrane technologies have become widely used in filtration and separation processes in chemical, oil, food, pharmaceutical, medical, environmental, textile industries, etc. Recently, there is a growing demand for the use of bactericidal membranes due to their effectiveness in neutralizing microorganisms. The aim of this work is to synthesize microfiltration ceramic membranes modified with silver nanoparticles to provide them with bactericidal properties. In this work, ceramic membranes are synthesized by dry pressing followed by sintering from natural raw materials of Ukrainian origin, namely: kaolin and saponite, as well as with the addition of silicon carbide, sodium silicate, and calcium carbonate. To provide ceramic membranes with bactericidal properties, they were modified with particles of silver. The synthesized ceramic membranes were characterized by X-ray diffraction and fluorescence analysis, and their bactericidal ability has been established. The ceramic filtration membranes after modification by silvers exhibited an inhibitory effect on the growth of Gram-positive (B. subtilis.) and Gram-negative (Escherichia coli) pathogens. Thus, the obtained bactericidal ceramic membranes are of great interest for their use for biofouling control.
USING COLLABORATIVE LEARNING APPROACH TO IMPROVE LEARNER’S MENTAL LEXICON OF WORD ASSOCIATION
Authors:   Language and Culture Hub, Institut Teknologi Kalimantan, Balikpapan, Indonesia, Susantiningdyah Healty , Inayati Nina ,   English Department, University of Muhammadiyah Malang, Malang, Indonesia, Suci Dirgantari Alfi ,   Language and Culture Hub, Institut Teknologi Kalimantan, Balikpapan, Indonesia, Clararissa AS Hilga ,   Language and Culture Hub, Institut Teknologi Kalimantan, Balikpapan, Indonesia
Published: February 2022

A collaborative learning approach has been identified to lessen anxiety and allow more comprehensible inputs to be processed cognitively to result in meaningful outputs. This study specifically examines the effectiveness of the collaborative learning approach and its best fit model supplemented with several techniques to improve students’ mastery of the mental lexicon of the word association. This Classroom Action Research involved 60 college students in their senior years in Institut Teknologi Kalimantan. The data collection involved two cycles in which each cycle employed planning, implementation, analysing learning activities and learning outcome and finally reflection. To gain insight through each cycle, a cloze test and a survey were administered. Furthermore, the result was analysed qualitatively and the finding reveals a significant improvement in terms of the mental lexicon of word association repertoire especially in cycle 2. The percentage of the students meeting the criteria of success doubled at 71.67% while the students’ learning perception throughout each cycle was successfully maintained. Collaborative learning also helped most students to create a positive perception to level up their mental lexicon mastery
The Antibacterial Activity of Red Dragon Fruit Peel (Hylocereus polyrhizus Britton & Rose) Methanolic Fraction Against Staphylococcus epidermidis and Propionibacterium acnes
Authors: Wahdaningsih Sri , Untari Eka Kartika
Published: February 2022

Acnes can be caused by Propionibacterium acnes and Staphylococcus epidermidis. Red dragon (Hylocereus polyrhizus B & R) fruit peels is one of natural materials which is assumed to possess an antibacterial activity. The purpose of this study was to determine the antibacterial activity of red dragon fruit peels methanol fraction (RDFPMF) against S. epidermidis and P. acne by disc diffusion Kirby-Bauer method. Red dragon fruit peels were maceration in chloroform and fractionation in methanol. Clindamycin 4µg/disk was used as positive control and DMSO 10% was used as negative control. This research showed that the RDFPMF has antibacterial activity against P. acnes which the average of inhibition zones obtained from the concentrations from 100, 50, and 25 mg/mL respectively were 10.5 ± 0.50 mm, 10.0 ± 0.00 mm, and 8.5 ± 0.50 mm. The RDFPMF has no inhibition zone toward S. epidermidis. The red dragon fruit peels methanol fraction has antibacterial activity on P. acnes by disc diffusion method (Kirby-Bauer test).
Matrix multiple regression and modern biometric methods for prediction of biological indicators: examples
Authors: Nazaraha Inna , Nazaraha Yaroslav
Published: February 2022

In this article, examples of prediction of biological indicators are considered. In this case, the classical methods of biometrics and methods based on matrix multiple regression are used. In order to solve the problem of estimation by the method of least squares for multiple matrix regression, a mathematical apparatus for the singular value decomposition (SVD) and pseudo-inversion technique for Moore–Penrose was used within the development of the concept of tuple operators. The empirical data for calculations were data from an experiment conducted at the Educational and Scientific Center “Institute of Biology and Medicine” (Taras Shevchenko National University of Kyiv). The calculations were made in Microsoft Office Excel and Wolfram Mathematica. The algorithm based on matrix multiple regression has the prediction accuracy in terms of the APE (absolute percentage error) criterion (the error is from 0% to 10%) higher than the accuracy of modern methods of biometrics (some errors are greater than 30%). As shown in the examples, matrix multiple regression can be an effective prediction instrument in biology with an acceptable planning processes accuracy.
Human natural killer cells for targeting delivery of gold nanostars and bimodal imaging directed photothermal/photodynamic therapy and immunotherapy
Authors: Liu Bin , Cao Wen , Cheng Jin , Fan Sisi , Pan Shaojun , Wang Lirui , Niu Jiaqi , Pan Yunxiang , Liu Yanlei , Sun Xiyang , Ma Lijun , Song Jie , Ni Jian , Cui Daxiang
Published: February 2022

Objective To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars (GNSs) with Chlorin e6 molecules (Ce6) into human peripheral blood mononuclear cells (PBMCs)-derived NK cells for tumor targeted therapy. Methods GNS@CaCO3/Ce6 nanoparticles were prepared and characterized by TEM and UV-vis. The cell surface markers and cytokines secretion of NK cells before and after loading the GNS@CaCO3/Ce6 nanoparticles were detected by Flow Cytometry (FCM) and ELISA. Effects of the GNS@CaCO3/Ce6-NK cells on A549 cancer cells was determined by FCM and CCK-8. Intracellular fluorescent signals of GNS@CaCO3/Ce6-NK cells were detected via Confocal laser scanning microscopic (CLSM) and FCM at different time points. Intracellular ROS generation of GNS@CaCO3/Ce6-NK cells under laser irradiation were examined by FCM. The distribution of GNS@CaCO3/Ce6-NK in A549 tumor-bearing mice were observed by fluorescence imaging and PA imaging. The combination therapy of GNS@CaCO3/Ce6-NK under laser irradiation were investigated on tumor-bearing mice. Results The coated CaCO3 shell on the surface of GNSs exhibited prominent delivery and protection effect of Ce6 during the cellular uptake process. The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells possessed bimodal functions of fluorescence imaging and photoacoustic imaging. The as-prepared multifunctional GNS@CaCO3/Ce6-NK cells could actively target tumor tissues with the enhanced photothermal/photodynamic therapy and immunotherapy. Conclusions The GNS@CaCO3/Ce6-NK shows effective tumor-targeting ability and prominent therapeutic efficacy toward lung cancer A549 tumor-bearing mice. Through fully utilizing the features of GNSs and NK cells, this new nanoplatform provides a new synergistic strategy for enhanced photothermal/photodynamic therapy and immunotherapy in the field of anticancer development in the near future.
Polarimetric Quantum-Strong Correlations with Independent Photons on the Poincaré Sphere
Authors: Vatarescu Andre
Published: February 2022

Polarization-based photonic quantum correlations can be traced back to the overlap of the polarization Stokes vectors on the Poincaré sphere between two polarization filters. Quantum-strong correlations can be obtained with independent polarization states on the Poincaré sphere. The quantum Rayleigh scattering prevents a single photon from propagating in a straight line inside a dielectric medium. The concept of quantum nonlocality is rather questionable because the quantum Rayleigh scattering in a dielectric medium destroys entangled photons.
The Importance of a Natural Social Contract and Co-Evolutionary Governance for Sustainability Transitions
Authors: Huntjens Patrick , Kemp René
Published: February 2022

The corona (COVID-19) pandemic offers an opportunity for dealing with persistent problems, through a transformative recovery process. It is a crisis that offers opportunities for dealing with three interrelated crises: the ecological crisis (climate change, loss of biodiversity, resource depletion, pollution and ecosystem destruction), the confidence crisis (people losing trust in government, politics, companies, regular news channels, science, each other and the future), and the inequality crisis (the widening of the gap between rich and poor). Our argument is that sustainability transitions will not succeed without a different economy and another social contract with the associated rights and duties of care (for the environment and the well-being of others, including future generations). A different social contract is not only desirable from the point of view of sustainability and fairness, justice and equality, but is also necessary to restore citizens' trust in politics, government, companies and each other. In the paper we discuss mechanisms towards a Natural Social Contract, systemic leverage points for system transformations and possibilities for co-evolutionary governance by actor coalitions interested in transformative change. The combination of those three elements helps to synchronize different agendas and reduce the chance that they will work against each other.
Field Campaign Evaluation of Sensors GMX500 and WS100 in Peruvian Central Andes
Authors: Valdivia Jairo M. , Guizado David A. , Flores-Rojas José L. , Gamarra Delia P. , Silva Yamina F. , Huamán Rosana E. , Suarez Luis F.
Published: February 2022

The research presents the inter-comparison of atmospheric variables measured by 9 automatic meteorological stations. This set of data was compared with the measurements of other meteorological stations in order to standardize the values that must be adjusted when taken to different areas. The data of a set of a total of 9 GMX500, which measures conventional meteorological variables, and 10 WS100 sensors, which measures precipitation parameters. The automatic stations were set up at the Huancayo Observatory (Geophysical Institute of Peru) for a period of 5 months. The data set of GMX500 were evaluated comparing with the average of the 9 sensors and the WS100 was compared with a optical disdrometer Parsivel2. The temperature, pressure, relative humidity, wind speed, rainfall rate, and drop size distribution was evaluated. A pair of GMX500 sensors presented high data dispersion, it was found found that the errors came from a bad configuration; once this problem was solved, good agreement was archived, with low RMSE and high correlation. I was found that the WS100 sensors overestimate the precipitation with a percent bias close to 100% and the differences increase with the greater intensity of rain. The DSD retrieved by WS100 have unrealistic behavior with higher concentrations in diameters of 1 mm and 5 mm, in addition to a flattened curve.
Establishment of Novel Neuroendocrine Carcinoma Patient-Derived Xenograft Models for Receptor Peptide-Targeted Therapy
Authors: Tran Catherine G , Borbon Luis C , Mudd Jacqueline L , Abusada Ellen , AghaAmiri Solmaz , Ghosh Sukhen C , Vargas Servando H. , Li Guiying , Beyer Gabriella V , McDonough Mary , Li Rachel , Chan Carlos HF , Cliften Paul F , Walsh Susan A , Wadas Thaddeus J , O’Dorisio Thomas M , O'Dorisio M Sue , Govindan Ramaswamy , Azhdarinia Ali , Bellizzi Andrew M , Fields Ryan C , Howe James R , Ear Po Hien
Published: February 2022

Gastroenteropancreatic neuroendocrine neoplasms (GEP NENs) are rare cancers consisting of neuroendocrine carcinomas (NECs) and neuroendocrine tumors (NETs), which have been increasing in incidence in recent years. Few cell lines and pre-clinical models exist for the study of GEP NECs and NETs, limiting the ability to discover novel imaging and treatment modalities. To address this gap, we isolated tumor cells from cryopreserved patient GEP NECs and NETs and injected them into the flanks of immunocompromised mice to establish patient-derived xenograft (PDX) models. Two of 6 mice developed tumors (NEC913 and NEC1452). Over 90% of NEC913 and NEC1452 tumor cells stained positive for Ki67. NEC913 PDX tumors expressed neuroendocrine markers such as chromogranin A (CgA), synaptophysin (SYP), and somatostatin receptor-2 (SSTR2) whereas NEC1452 PDX tumors do not express SSTR2. Exome sequencing revealed loss of p53 and RB1 in both tumors. To demonstrate an application of these novel NEC PDX models for SSTR2-targeted peptide imaging, the NEC913 and NEC1452 cells were bilaterally injected into mice. Near infrared-labelled octreotide was administered and fluorescent signal was specifically observed for the NEC913 SSTR2 positive tumors. These 2 GEP NEC PDX models serve as valuable resource for GEP NEN therapy testing.
Motivasi anggota kelompoktani dalam peningkatan fungsi kelompoktani padi sawah di Kecamatan Bendahara Kabupaten Aceh Tamiang
Authors: Herawaty Herawaty , Siregar Ameilia Zuliyanti , Simanjuntak Nadia Br
Published: February 2022

Tujuan dari pengkajian ini adalah untuk mengetahui tingkat motivasi petani mengenai fungsi kelompoktani dan faktor-faktor yang mempegaruhi motivasi petani dalam berkelompok tani. Penelitian dilakukan dikecamatan Bendahara Kabupaten Aceh Tamiang Provinsi Aceh dan dilaksanakan pada April 2021. Metode pengumpulan data dengan wawancara, observasi dan kuisioner yang telah diuji validitas dan reliabilitasnya, dengan metode analisis data menggunakan skala Likert dan Uji Regresi Linear Berganda. Hasil penelitian menunjukkan tingkat motivasi petani padi sawah mengenai fungsi kelompoktani tergolong sangat tinggi dengan persentase 84%. Variabel Umur, pendapatan, pendidikan dan luas lahan merupakan variabel yang berpengaruh sacara signifikan terhadap motivasi kelompoktani petani sawah. Manakala pengetahuan tidak berpengaruh signifikan secara parsial dalam penelitian ini.
Virtual Reality in Military Training to Maintain Indonesian Military Readiness in The Era of Covid-19 Pandemic
Authors: K L Herdayatamma
Published: February 2022

During the COVID-19 pandemic, there have been many changes to human activities, not to mention Indonesia's military armed forces (TNI). Despite the COVID-19 pandemic, threats to national security still exist. There are even some potential threats that developed during the COVID-19 pandemic and could explode at any time. This article is written based on a qualitative method and used a literature study approach of various literature that related to the topic. The author wants to show the importance of maintaining Indonesian Military Armed Force (TNI) readiness by continuing military education and training with some adjustments. Virtual Reality has become the solution to this problem. With fully immersive system technology, VR can provide an experience that is closest to reality. So that even in a pandemic condition with a policy of restricting human activities, military readiness can still be maintained.
Machine Learning Models for Predicting the Occurrence of Respiratory Diseases Using Climatic and Air-Pollution Factors
Authors: Ku Yunseo , Kwon Soon Bin , Yoon Jeong-Hwa , Mun Seog-Kyun , Chang Munyoung
Published: February 2022

Objectives. Because climatic and air-pollution factors are known to influence the occurrence of respiratory diseases, we used these factors to develop machine learning models for predicting the occurrence of respiratory diseases.Methods. We obtained the daily number of respiratory disease patients in Seoul. We used climatic and air-pollution factors to predict the daily number of patients treated for respiratory diseases per 10,000 inhabitants. We applied the relief-based feature selection algorithm to evaluate the importance of feature selection. We used the gradient boosting and Gaussian process regression (GPR) methods, respectively, to develop two different prediction models. We also employed the holdout cross-validation method, in which 75% of the data was used to train the model, and the remaining 25% was used to test the trained model. We determined the estimated number of respiratory disease patients by applying the developed prediction models to the test set. To evaluate the performance of each model, we calculated the coefficient of determination (R2) and the root mean square error (RMSE) between the original and estimated numbers of respiratory disease patients. We used the Shapley Additive exPlanations (SHAP) approach to interpret the estimated output of each machine learning model.Results. Features with negative weights in the relief-based algorithm were excluded. When applying gradient boosting to unseen test data, R2 and RMSE were 0.68 and 13.8, respectively. For GPR, the R2 and RMSE were 0.67 and 13.9, respectively. SHAP analysis showed that reductions in average temperature, daylight duration, average humidity, sulfur dioxide (SO2), total solar insolation amount, and temperature difference increased the number of respiratory disease patients, whereas increases in atmospheric pressure, carbon monoxide (CO), and particulate matter ≤2.5 μm in aerodynamic diameter (PM2.5) increased the number of respiratory disease patients.Conclusions. We successfully developed models for predicting the occurrence of respiratory diseases using climatic and air-pollution factors. These models could evolve into public warning systems.
Slipped Capital Femoral Epiphysis Associated with Endocrinopathy
Authors: Shaw K. Aaron , Shiver A. Luke , Oakes Tannur , Fletcher Nicholas D.
Published: February 2022

» Slipped capital femoral epiphysis (SCFE) has a well-documented association with underlying endocrine conditions, including thyroid hormone aberrations and parathyroid dysfunction.

» Recombinant growth hormone therapy has also been identified as a risk factor for the development of SCFE.

» Presentation before their 10th birthday or after their 16th birthday along with height of <10th percentile are reliable risk factors for identifying children with an SCFE who are at a heightened risk for an underlying endocrinopathy and can been used to guide selective laboratory testing.

» Patients with unilateral SCFE presentations with an underlying endocrinopathy are at a heightened risk for contralateral slip development and should be treated with prophylactic fixation.
BIOCHAR-KOMPOS BERBASIS LIMBAH KELAPA SAWIT: Bahan Amandemen untuk Memperbaiki Kesuburan dan Produktivitas Tanah Di Lahan Rawa
Authors: Annisa Wahida
Published: February 2022

Umumnya untuk mengurangi toksisitad baik Al3+dan Fe2+ di lahan rawa dengan pengapuran, namun ini bukan solusi yang tepat karena tidak untuk jangka Panjang, karena pengapuran hanya menyembuhkan gejalanya saja.  Penambahan bahan amandemen tanah seperti bahan organic dan kompos merupakan solusi yang tepat untuk mengatasi permasalahan di lahan rawa.  Pesatnya perkembangan industri kelapa sawit di Indonesia, mengakibatkan semakin besar juga limbah biomassa yang di hasilkan.  Tandan buah kosong kelapa sawit merupakan limbah terbesar yang dihasilkan dari perkebunan sawit dibandingkan dengan limbah kelapa sawit lainnya seperti cangkang sawit.  Pengelolaan biomassa tandan buah kosong kelapa sawit dalam jumlah besar dengan metode konvensional seperti penimbunan lahan dan pembakaran di pabrik akan menimbulkan masalah dampak lingkungan yang serius.  Pengomposan dan mengubah menjadi biochar menjadi salah satu alternatif untuk pengelolaan limbah yang menghasilkan amandemen tanah untuk memperbaiki kesuburan tanah rawa dan produktivitas serta memulihkan daerah yang terkontaminasi dengan logam yang berpotensi beracun.  Paper ini menggunakan metode sistematik review yang merangkum hasil-hasil penelitian primer.  Tujuan penulisan paper ini adalah: mensintesis seluruh hasil penelitian secara kualitatif untuk menggali potensi biochar dan kompos sebagai bahan amelioran untuk meningkatkan kesuburan dan produktivitas tanah di lahan rawa. 

Kata Kunci: biomassa kelapa sawit, unsur toksik, dekomposisi, pirolisis, sifat kimia
Electromagnetic Compatibility of Compensating Devices and Converters of an Adjustable Electric Drive in Electrical Networks of Industrial Enterprises
Authors: Schasny V. P. , Zhukouski A. I.
Published: February 2022

The problems of reactive power compensation and improving the quality of electrical energy in the power supply systems of industrial enterprises are inseparable. Their relevance is due to the widespread use of electric receivers that consume reactive power and distort the quality of electrical energy in the network, as well as the implementation of new technologies, systems and equipment into production that make increased demands on the quality of electrical energy consumed. An important characteristic of the quality of electrical energy rationed by GOST 32144–2013 is the non-sinusoidal voltage. The main reason for the non-sinusoidal voltage in the electrical networks of industrial enterprises is the use of electrical equipment with a nonlinear voltage characteristic, which is a source of conductive electromagnetic interference, in particular: adjustable DC and AC electric drives, uninterruptible power supplies of electric receivers, electric welding equipment, electric arc furnaces, induction heating installations, gas-discharge radiation sources. Due to the nonlinearity of the current-voltage characteristics, the above devices consume a non-sinusoidal current from the network, which causes harmonic distortion of the supply voltage, including the fundamental harmonic component and higher harmonic components that are multiples of the fundamental frequency. Non-sinusoidal voltage, in turn, causes additional losses of power and energy in the elements of the electrical network, causes overheating and accelerated aging of the insulation of electrical equipment, reducing its operational reliability and reducing service life, worsens the accuracy of electrical measurements, causes malfunctions in automation systems, telemechanics, relay protection, electronic systems and communications. Non-sinusoidal voltage significantly complicates the compensation of reactive power in the electrical network. Compensating devices are made on the basis of capacitors, whose electrical parameters (resistance, power, current) depend on both the magnitude of the supply voltage and its harmonic composition. The present article identifies problems and proposes solutions in terms of reactive power compensation and improving the quality of electrical energy in electrical networks containing thyristor voltage converters and frequency converters used in adjustable electric drive installations of industrial enterprises.