bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Edukasi Apoteker Terhadap Tahap Berhenti Merokok pada Mahasiswa Perokok Aktif Tahap Contemplation
Authors: Siswati Siswati , Sarniatnto Prih , Andayani Nurita
Published: April 2021

Kebiasaan merokok merupakan salah satu kebiasaan tidak sehat yang potensial menimbulkan penyakit kronis, seperti Diabetes Melitus tipe 2, penyakit kardiovaskular, penyakit jantung koroner, kanker paru dan penyakit pernafasan kronis. Masih banyaknya mahasiswa yang merokok, memerlukan pendekatan seperti adanya edukasi apoteker terhadap upaya berhenti merokok. Perilaku berhenti merokok terbagi menjadi beberapa tahapan, yaitu: tahap pre-contemplation, contemplation, preparation, action, maintenance dan relapse. Pada tahap contemplation, perokok telah berfikir serius untuk berhenti merokok. Intervensi edukasi oleh apoteker sebagai salah satu tenaga kesehatan, terutama pada perokok yang berada pada tahap contemplation merupakan hal penting yang dapat  menunjang keberhasilan upaya berhenti merokok,sehingga mahasiswa perokok dapat berada pada tahap selanjutnya dari tahap contemplation. Penelitian ini memiliki desain studi quasi eksperimental pre-test dan post test dan pengumpulan data menggunakan metode purposive sampling. Penelitian ini bertujuan untuk mengetahui pengaruh edukasi apoteker terhadap perilaku berhenti merokok pada mahasiswa perokok aktif tahap contemplation. Dengan responden 43 mahasiswa perokok aktif tahap contemplation, hasil penelitian diuji dengan uji t one pair, untuk melihat pengaruh edukasi apoteker terhadap perilaku berhenti merokok. Hasil penelitian menunjukkan, edukasi apoteker memberikan perubahan yang bermakna pada nilai Urica Scale tahap perilaku berhenti merokok, namun tidak merubah tahap berhenti merokok responden, dimana sebelum edukasi adalah contemplation, sesudah edukasi juga tetap berada di tahap contemplation.
Long-Term Infectious Complications of Kidney Transplantation
Authors: Agrawal Akansha , Ison Michael G. , Danziger-Isakov Lara
Published: April 2021

Infections remain a common complication of solid-organ transplantation. Most infections in the first month after transplant are typically health care–associated infections, whereas late infections, beyond 6–12 months, are community-acquired infections. Opportunistic infections most frequently present in the first 12 months post-transplant and can be modulated on prior exposures and use of prophylaxis. In this review, we summarize the current epidemiology of postkidney transplant infections with a focus on key viral (BK polyomavirus, cytomegalovirus, Epstein-Barr virus, and norovirus), bacterial (urinary tract infections and Clostridioides difficile colitis), and fungal infections. Current guidelines for safe living post-transplant are also summarized. Literature supporting prophylaxis and vaccination is also provided.
Social Responsibility, Institutional Environment and Stock Price Crash Risk: Evidence from Chinese GEM
Authors: Yuying Zhou , Yuyu Wang
Published: April 2021

The stock price crash risk has become the focus of corporate finance and macroeconomics research in recent years because it affects the stock market, listed companies, market investors and the real economy. This paper takes 1822 gem listed companies from 2011 to 2017 as samples, and empirically tests the impact of social responsibility on the risk of stock price collapse and takes into account the regulatory effect of institutional environment. The study finds that social responsibility can inhibit the stock price collapse risk of listed companies on the growth enterprise market, and the institutional environment can also inhibit the risk of stock price collapse of listed companies on the growth enterprise market. Considering the influence of the institutional environment, the influence of social responsibility on the risk of stock price collapse of listed companies on the growth enterprise market is more obvious, which shows that the institutional environment has a moderating effect between social responsibility and the risk of stock price collapse. This conclusion still exists after considering the endogenous influence. Further research shows that the inhibiting effect of social responsibility and the regulating effect of institutional environment are more obvious among gem listed companies in the first year of listing.
Generator of genetic seismic signals
Authors: García Silvia , Alcántara Leonardo
Published: April 2021

En este trabajo se presenta un método original para el ensamblado de acelerogramas compatibles con un espectro objetivo preestablecido. El procedimiento se basa en un generador de señales sísmicas, el cual toma en consideración las características del evento sísmico y las condiciones del subsuelo para hacer una representación realista de los movimientos del terreno. Se utilizan operadores genéticos para transformar en forma iterativa los acelerogramas, imitando los procesos de apareamiento, selección natural y mutación. El generador de señales sísmicas genéticas, modifica los componentes de aceleración de los registros considerados buenos padres para producir individuos exitosos o nuevas señales óptimas que mejor se ajustan a las condiciones objetivo. El procedimiento es inmediato y consistente con resultados notables en registros que coinciden con una amplia variedad de espectros objetivo, con una desviación mínima y conservando las cualidades geotécnicas y sismológicas inherentes de los padres (acelerogramas registrados).
Radon as a natural radiotracer to investigate infiltration from surface water to nearby aquifers: a case study from the Barada riverbank, Syria
Authors: Al-Hilal Mohamed
Published: April 2021

El radón (222Rn) es un gas radiactivo inerte emanado constantemente de los suelos, rocas y aguas subterráneas, lo cual se debe a la desintegración alfa del radio (226Ra). La radiactividad, la inercia y la naturaleza gaseosa del radón lo convierten en un indicador ambiental significativo para el análisis de algunos problemas hidrogeológicos que implican interacciones entre las aguas superficiales y subterráneas. El objetivo principal del presente estudio es investigar la posible infiltración de las aguas superficiales del río Barada, ubicado en la cuenca de Damasco, a un acuífero adyacente, que incluye algunos pozos que son explotados para contribuir a la red de agua potable de la ciudad de Damasco. La técnica aplicada se basa en el principio de que, a medida que el agua del río de radón bajo fluye a través de la matriz del acuífero, absorbe continuamente el radón emanado de los sedimentos arcillosos del acuífero, alcanzándose el equilibrio entre la captación de radón y la desintegración radiactiva. La distribución de la variación espacial del radón en el agua subterránea se ha monitoreado en cuatro pozos preexistentes perforados en un sistema acuífero fluvial a lo largo del margen de la orilla del río Barada. Los resultados revelaron un claro crecimiento de la concentración de radón en tres o cuatro órdenes de magnitud, con lo cual se alcanzó un estado de equilibrio estable después de aproximadamente cuatro vidas medias. Con base en la ley estándar de radiactividad, se estimó el tiempo de residencia del agua del río infiltrado. Los datos hidroquímicos además de las investigaciones geológicas y las actividades de radón revelaron principalmente evidencias de infiltración del agua del río Barada al sistema de acuíferos cercano, el cual puede volverse vulnerable ante el riesgo de contaminación ambiental. Finalmente, los resultados también mostraron que el aumento de radón en el agua subterránea se correlaciona positivamente con la concentración de EC (R2 = 0.89) y, en menor medida, con los valores de TDS (R2 = 0.67). Esta asociación evidente probablemente se deba a la presencia de algo de materia orgánica y minerales arcillosos en los sedimentos de la matriz del acuífero.
Present-day stress state in northwestern Syria
Authors: Abdul-Wahed Mohamad Khir , ALISSA Mohammed
Published: April 2021

Northwestern Syria is a key area in the eastern Mediterranean to study the active tectonics and stress pattern across the Arabia-Eurasia convergent plate boundary. This study aims to outline the present-day stress regime in this region of Syria using the fault plane solutions of the largest events recorded by the Syrian National Seismological Network from 1995 to 2011. A dataset of fault-plane solutions was obtained for 48 events having at least 5 P-wave polarities. The tectonic regime for most of these events is extensional and produces normal mechanisms in agreement with the local configurations of the seismogenic faults in the region. Strike-slip mechanisms are more scarce and restricted to certain areas, such as the northern extension of the Dead Sea fault system. The results of the current study reveal the spatial variations of SHmax orientation across the northwestern Syria region. This spatial variation of the present-day stress field highlights the role of main geometrically complex shear zones in the present-day stress pattern of northwestern Syria. However, these results show, regardless of the relatively small magnitudes of the studied events, they provide a picture of the local stress deviations that have currently been taking place along the local active faults.
Biodiversidad bacteriana en un riachuelo con vertido continuo de efluentes de hidrocarburos
Authors:   Universidad del Zulia, Venezuela, Ruiz Marelis M. , de Souza Carvalho Elen Bethleen ,   Universidad Federal do Amazonas UFAM, Manaus, de Oliveira Marcelo ,   Universidad Federal del Amazonas UFAM, César Ladeira Bruno ,   Petrobras UN-AM
Published: April 2021

Desde el inicio de sus operaciones, la provincia petrolera de Urucu (Petrobras unidad Amazonas, Brasil, UN-AM) ha realizado el vertido continuo de efluentes de hidrocarburos en riachuelos alrededor de sus instalaciones. El objetivo de esta investigación fue realizar un análisis de la comunidad bacteriana existente en un riachuelo (comunidad 1: antes del vertido, comunidad 2: después del vertido). Se colectaron muestras de agua en riachuelo para extraer el DNA genómico total y usarlo como molde en la PCR, con oligonucleótidos específicos del gen 16S rDNA para dominio Bacteria. El producto de la PCR fue amplificado, y las secuencias generadas por técnica de pirosecuenciación, fueron analizadas con el programa libre Mothur. Los resultados revelaron que el filo Acidobacteria, la clase Deltaproteobacteria y los géneros Gp3 y Geobacter, mostraron alta presencia en comunidad 1. Asimismo, el filo Proteobacteria fue el más abundante, con la clase Betaproteobacteria y los géneros Geobacter y Gp3, como los predominantes en comunidad 2. Los índices de riqueza presentaron variación porcentual en ambas comunidades (disminución e incremento), siendo la diversidad más abundante en la comunidad 1. Sin embargo, no se encontró diferencia significativa entre ambas comunidades (p>0,001), y todas muestras de cada comunidad presentaron la misma estructura genética (p<0,05). El 25 % de los géneros bacterianos se consideraron “no clasificados”, y aproximadamente el 15 % de los géneros fueron clasificados como biorremediadores. Estos datos representan un desafío para la exploración biotecnológica en este ecosistema, con potencial para identificar y clasificar nuevos grupos taxonómicos.
Eficiencia de Uso del Agua en Riego por Goteo Superficial y Subsuperficial en Zea mays L.
Authors:   Universidad Técnica de Machala, Machala, Conde-Solano José Lauro , Sánchez-Urdaneta Adriana Beatriz ,   Universidad del Zulia, Venezuela, Colmenares de Ortega Ciolys Beatriz ,   Universidad del Zulia, Venezuela, Ortega Alcalá Jorge ,   Universidad del Zulia, Venezuela, Vásquez Edison Ramiro ,   Universidad Nacional de Loja
Published: April 2021

En la producción de alimentos el agua constituye un factor limitante; por ello, es preciso alcanzar la máxima eficiencia del uso de este recurso en los sistemas agrícolas. Se evaluó la eficiencia del uso de agua del riego por goteo superficial y subsuperficial en el cultivo de Zea mays L. Se cultivaron 1.600 m2 de maíz híbrido duro, con cuatro tratamientos: riego por goteo superficial (T1, testigo) y subsuperficial a 10 (T2), 20 (T3) y 30 (T4) cm de profundidad, con cuatro repeticiones. En un diseño en bloques al azar, cada unidad experimental tuvo 100 m2 (10 x 10 m). Se realizó un análisis de varianza y comparación de medias mediante la prueba de Tukey. Se evaluó el rendimiento, eficiencia del uso del agua (EUA), frecuencia, tiempo y lámina de riego, y diámetro del bulbo humedecido. Hubo diferencias estadísticas para todas las variables evaluadas (p<0,01), excepto para la lámina de agua por riego por efecto de los tratamientos. El rendimiento (10.263 kg/ha), EUA (7,92 kg/m3) y diámetro (0,145 m) del bulbo húmedo fueron mayores en T3 y T4; la frecuencia de riego (3,6 días) y la lámina total de agua fue menor en T3 y T4 (129 mm); el tiempo total de riego fue menor en T4 (34,08 h). El riego por goteo subsuperficial a 20 y 30 cm de profundidad presentó la mayor eficiencia.
Evaluación del comportamiento del acero 1,25Cr0,5Mo en condiciones de fluencia lenta
Authors:   Universidad Central “Marta Abreu” de Las Villas, Fernández-Fuentes Alfonso Rafael , Cruz-Crespo Amado ,   Universidad Central “Marta Abreu” de Las Villas, Scotti Americo ,   Universidade Federal de Uberlândia, Guedes-De Alcãntara Nelson ,   Universidade Federal de São Carlos
Published: April 2021

Los estudios sobre la influencia del tratamiento térmico pos soldadura en la microestructura y comportamiento mecánico de tuberías de vapor, se han enfocado en la región de la soldadura (metal fundido y zona afectada por el calor); sin embargo, dicho proceso tiene un efecto térmico que va más allá de esta región, el cual no ha sido suficientemente detallado. El presente trabajo tuvo como objetivo evaluar el efecto del tratamiento térmico sobre la microsetructura y el comportamiento en fluencia lenta de la región que no es térmicamente afectada por la soldadura. El material analizado fue tomado de una tubería de vapor (acero 1,25Cr0,5Mo, 20 años envejecido en servicio a 480 oC). Una parte de la tubería fue sometida a tratamiento térmico, con parámetros de acuerdo con el código ASME de calderas y recipientes a presión. Se obtuvo el tiempo de rotura en ensayo de fluencia lenta y la microestructura del material envejecido en servicio, así como del tratado térmicamente. El tratamiento térmico del acero 1,25Cr0,5Mo envejecido en servicio aumentó el tamaño de los precipitados presentes en el interior de la ferrita y disminuyó la resistencia a la fluencia lenta.
Comportamiento experimental de conexiones soldadas entre tubos cuadrados de acero conformados por perfiles G de 60x30x10x2 y 80x40x15x3 mm sometidas a carga monotónica
Authors:   Universidad Politécnica Salesiana, Romero Romero Carlos Alberto
Published: April 2021

En el Ecuador se ha incrementado el uso de conexiones con tubulares cuadrados de acero en viviendas y centros comerciales. Sin embargo, no existe una normativa que explique su comportamiento. En esta investigación se evaluó el comportamiento experimental de dicha conexión. Para ello, se realizaron ensayos donde se analizó el comportamiento elastoplástico de juntas soldadas con tubos cuadrados de acero conformados por perfiles G de 60x30x2 y 80x40x3 mm, sometidas a carga monotónica. Cada prueba consistió en imponer carga progresiva en la conexión superior del pórtico, para medir los desplazamientos y distorsión de la geometría de los elementos unión viga-columna de la conexión inferior. Los resultados evidencian que la carga de colapso experimental en los pórticos 1, 2 y 3 (conexión sin refuerzo) disminuyó 12,82 % con respecto al valor teórico, mientras que en los pórticos 4, 5 y 6 (conexión reforzada) se incrementó en 14,96 %. El reforzamiento está conformado por platinas instaladas en la columna de la conexión inferior. Con ello, se ha evitado la falla por pandeo local y se ha garantizado la formación de rótulas plásticas en la viga de la unión soldada, cumpliendo así el criterio de viga débil-columna fuerte.
Intensification of activated sludge sedimentation processes by means of vacuuming
Authors: Kulakov Artem A. , Filatova Alina F.
Published: April 2021

Introduction. The mixed liquor of nitrogen removal wastewater treatment plants is characterized by a high concentration of nitrates and dissolved oxygen at the inlet to the secondary settling tank. In the sludge layer of secondary sedimentation tanks, conditions of decreased oxygen content and uncontrolled denitrification processes take place. This leads to the floating up and removal of sludge with the effluent and secondary pollution of treated water. The purpose of this article is to study the parameters of activated sludge sedimentation in municipal wastewater treatment plants and their intensification by means of vacuuming.

Materials and methods. The studies were carried out under laboratory conditions. Activated sludge vacuuming and sedimentation processes were simulated. Diagrams of the “sludge-water” phase reduction (Kinsh curves) were drawn. Mathematical and graphic processing of the results was carried out.

Results. Biological treatment of municipal wastewater (aerotank — secondary settling tank) and methods of its intensification by influencing the activated sludge were considered in this article. Trends of activated sludge (at different concentrations of mixed liquor suspended solids) sedimentation were experimentally obtained for municipal wastewater treatment plants. The process of sludge vacuuming was researched, the process efficiency was determined as a function of the treatment time.

Conclusions. Vacuuming allows removing gases from the fluid, which accelerates the process of sludge separation from the treated water and prevents it from floating to the surface. The treated sample is characterized by better sedimentation characteristics, density, coarseness and integrity of flakes. The optimal duration of mixed liquor vacuuming before sedimentation is 0.5 minutes; this accelerates the processes of subsequent sedimentation and reduces the removal of sludge with treated water. The results of laboratory tests can be applied to the design of the mixed liquor vacuuming unit before the secondary sedimentation tanks and its sludge separation.
Using deliberation to address controversial issues: Developing Holocaust education curriculum for Latvian schools
Authors: Misco Thomas
Published: April 2021

This paper explores how a cross-cultural project responded to the need for new Holocaust educational materials for the Republic of Latvia through the method of curriculum deliberation. Analysis of interview, observational, and document data drawn from seven curriculum writers and numerous project members suggest that curriculum deliberation helped awaken a controversial and silenced history while attending to a wide range of needs and concerns for a variety of stakeholders. The findings highlight structural features that empowered the curriculum writers as they engaged in protracted rumination, reflected upon competing norms, and considered the nuances of the curriculum problem in relation to implementation. Understanding the process, challenges, and promises of cross-cultural curriculum deliberation holds significance for educators, curricularists, and educational researchers wishing to advance teaching and learning within silenced histories and controversial issues.
APRENDIZADOS NAS ENTRELINHAS: REFLEXÕES E OLHARES FEMININOS NO TRABALHO ETNOBIOLÓGICO
Authors: Blanco Graziela Dias , Zank Sofia , Cantelli Daniele , Da Silva Bruna , Cunha Suelen Maria Beeck da , Gonçalves Maiara Cristina , Hanazaki Natalia
Published: April 2021

Apresentamos neste ensaio um pequeno conjunto de relatos de caso recolhidos entre um grupo de pesquisadoras do Laboratório de Ecologia Humana e Etnobotânica da Universidade Federal de Santa Catarina. São casos observados ao longo de 15 anos de experiências de campo e fora dele, em torno do universo da pesquisa científica, que envolve pessoas como sujeitos/as/es em várias facetas do trabalho acadêmico. Relatamos experiências de campo que mostraram os desafios das pesquisadoras e das entrevistadas, e a força e o poder de mulheres na luta e na gestão de recursos e cuidado da comunidade, mas que muitas vezes permanecem invisíveis. Refletimos também sobre as dificuldades de lidar com situações de machismo ou micromachismo nas comunidades que trabalhamos. Nossos relatos provêm de experiências com mulheres comuns e com lideranças comunitárias; agricultoras; indígenas; pescadoras; quilombolas; mulheres do trabalho do lar e de fora dele. Mulheres de diferentes saberes e fazeres e que diariamente enfrentam uma luta em comum, ser mulher, incluindo também nossas experiências como mulheres e pesquisadoras na área acadêmica. Entre entrevistas, observações e aprendizados, proporcionamos narrativas para somar aos questionamentos e reflexões de pesquisadoras(es) no campo das etnociências.
Eksplorasi Pendugaan Hara Daun Tanaman Kelapa Sawit Menggunakan Pesawat Tanpa Awak dan Kamera Multispektral
Authors: Santoso Heri , Winarna Winarna
Published: April 2021

Rekomendasi pemupukan umumnya disusun setiap tahun untuk mengkoreksi kebutuhan hara tanaman melalui kegiatan pemupukan. Hara daun dalam penyusunan rekomendasi pemupukan merupakan bagian kecil dari beberapa parameter yang digunakan. Beberapa peneliti telah melakukan prediksi hara daun tanaman kelapa sawit memanfaatkan data satelit multispektral dan pengukuran spectroradiometer dengan hasil yang bervariasi. Penelitian prediksi hara daun kelapa sawit dengan pesawat tanpa awak dan kamera multispektral ini dilakukan karena belum ada kajian mengenai penggunaan teknologi tersebut untuk prediksi hara daun kelapa sawit. Tujuan penelitian ini adalah membandingkan performa pendugaan hara daun dari berbagai variasi komposisi variabel berupa 3 saluran dan beberapa indeks vegetasi, serta untuk menentukan analisis regresi terbaik. Band hijau, merah, dan inframerah dekat dari kamera multispektral Mapir Survey 3, serta indeks vegetasi simple ratio, normalized difference vegetation index, dan green NDVI digunakan sebagai variabel bebas dalam analisis regresi sederhana, regresi polinomial, regresi berganda dari variabel terseleksi dengan teknik recursive feature elimination dengan metode regresi linear dan random forest, dan regresi berganda polinomial dengan variabel tidak bebas (respons) berupa analisis daun dari 20 sampel yang meliputi hara N, P, K, Ca, Mg, dan B. Model penduga terbaik dari penelitian ini adalah model regresi berganda polinomial dari variabel terseleksi menggunakan teknik RFE metode random forest. Variabel bebas hanya mampu menduga hara daun N, P, K, dan Mg dengan nilai R2 sebesar 0,9415 hingga 0,9991, Adjusted R2  sebesar 0,7223 hingga  0,9837, serta nilai residual standard error (RSE) sebesar 0,0045 hingga 0,0340.
UNSYMMETRIC OSCILLATIONS OF ANISOTROPIC PLATEHAVING AN ADDITIONAL MASS
Authors: Koreneva Elena
Published: April 2021

The problem of unsymmetric oscillations of circular plate made from anisotropic material is examined. The plate under consideration has an additional point mass attached offthe center or a system of additional masses. Also the oscillations of anisotropic circular plate with a point support placed offthe center are studied. The exact analytical approach is used for the decision of the above-mentioned problems; the method of compensating loads is applied. For this aim the basic and the compensating solutions are received. The basic solution satisfiesto the resolving differentialequation of the problem under study. The compensating solution satisfiesto the corresponding homogeneous equation and this solution amounting to the basic one also satisfiesto the boundary conditions. The Nielsen’s equation is used for the receiving of the exact solutions expressed in terms of Bessel functions. The equation for determination of frequencies of natural vibrations is obtained.
Successful surgical treatment approach for mitral valve vegetation of infective endocarditis after severe soft tissue infection with mediastinitis.
Authors: Uchida Kenichiro , Takahashi Yosuke , Shibata Toshihiko , Mizobata Yasumitsu
Published: April 2021

Transesophageal echocardiography is mandatory if you do suspect
infective endocarditis. By approaching via a small right thoracotomy,
vegetectomy and mitral valvuloplasty following severe mediastinitis were
successfully accomplished without any complications.
Food protein-induced enterocolitis syndrome: a large French multicentric experience
Authors: Lemoine Anaïs , Colas Anne-Sophie , LE Sebastien , Delacourt Christophe , Tounian Patrick , LEZMI Guillaume
Published: April 2021

Background Food protein-induced enterocolitis syndrome (FPIES) is a non
IgE-mediated food allergy, with potential dehydration secondary to
vomiting. Differences exist regarding culprit foods, onset symptoms, and
age of tolerance depending on the country of origin. We aimed to
describe the characteristics of a French population of children with
FPIES. Methods Data from 179 children who were referred for acute or
chronic FPIES in two pediatric tertiary centers between 2014 and 2020
were retrospectively collected. The diagnosis of FPIES was based on
international consensus guidelines. Clinical characteristics, culprit
food and age at resolution were assessed. Results In the 192 described
FPIES, the age at first symptoms was 5.8 months old. The main offending
foods were cow’s milk (60.3%), hen’s egg (16.2%), and fish (11.7%).
Single FPIES was observed in 94.4% and multiple FPIES in 5.6% of
cases. The age at resolution of FPIES was 2.2 years old, and resolution
occurred later for fish than for milk (2.9 years versus 2.0, p=0.01).
Severe acute FPIES was a risk factor for delayed resolution (relative
risk: 3.3 [1.2-9.2]), but not IgE sensitization. Performing an oral
food challenge within 12 months after the first reaction increased the
risk of failure (RR: 2.0 [1.2-3.5]). Conclusion In this French
cohort of children with FPIES, the main culprit foods were ubiquitous.
Rice, oat and soy were rarely or not involved. Multiple FPIES was
infrequent. Our data confirmed the overall good prognosis of FPIES, the
later resolution of FPIES to fish and in the case of severe acute FPIES.
Statin related musculoskeletal complications; Necrotizing Autoimmune Myositis… more than Myalgia.
Authors: Scheuing William , Dadhania Dadhania , Bankole adegbenga
Published: April 2021

Statins are widely prescribed and well tolerated with most side effects
now considered a nocebo effect. Occasionally, statins can be associated
with immune mediated necrotizing myositis that is both difficult to
diagnose and treat. Aggressive immunosuppressive therapy is the best
recognized method of treatment of this complication.
Telomere dysfunction is associated to dark-induced coral bleaching in the reef coral Stylophora pistillata
Authors: Gilson Eric , Rouan Alice , Tambutté Sylvie , Zoccola Didier , POUSSE Melanie , Tambutté Eric , Djerbi Nadir , Capasso Laura , Zozaya William
Published: April 2021

Telomere DNA length is a complex trait controlled both by multiple loci
and environmental factors. Even though the use of telomere DNA length
measurement, as a method of assessing stress accumulation and predicting
how this will influence survival, is currently being studied in numerous
human cohort studies, the importance of telomere length for stress
response in ecological studies remains at its infancy. Here, we
investigated the telomere changes occurring in the symbiotic coral
Stylophora pistillata that has experienced a continuous darkness over
six months. This stress condition led to the loss of its symbionts, as
what is also observed when bleaching occurs in the field at a
large-scale due to climate changes and anthropogenic activities,
threatening the worldwide reef ecosystem. We found that the continuous
darkness condition was associated with telomere DNA length shortening
and a downregulation of the expression of the telomere-associated
protein Pot2. These results pave the way for future studies on the role
of telomere in coral stress response and the importance of telomere
dysregulation in endangered coral species.
Thermostable intravenous epoprostenol for the treatment of pulmonary arterial hypertension -- a transition safety study
Authors: MacLellan Alexander , Carson Karon , Brewis Melanie , Johnson Martin , Church Colin
Published: April 2021

Intravenous epoprostenol remains an important treatment for pulmonary
arterial hypertension (PAH) but can only be given intravenously. Until
recently the only formulation available to our patients (Flolan 10.5)
was thermolabile and required daily preparation. In 2016, we
transitioned all patients in our service to a new, thermostable
formulation (Flolan 12). All patients in our unit using epoprostenol as
of November 2016 were recruited to this prospective study which examined
for safety issues and effects on QoL, 6MWD and serum NT-proBNP. We also
collected qualitative data regarding activities of daily living. The
transition process did not result in any clinical deterioration. There
were no safety issues identified and all but one of the participants
preferred the new formulation. We therefore conclude that transitioning
patients from intravenous Flolan 10.5 to Flolan 12 is safe, does not
lead to any clinical deterioration and is acceptable to patients for
reasons of convenience.
eHealth tools for childhood cancer survivorship care: A qualitative analysis of survivors’, parents’, and general practitioners’ views.
Authors: Schaffer Maria , McLoone Jordana , Wakefield Claire , Brierley Mary-Ellen , Girgis Afaf , McCarthy Maria , Thornton-Benko Elysia , Chan Raymond , Johnston Karen , Cohn Richard , Signorelli Christina
Published: April 2021

Purpose: The long-term management of childhood cancer survivors is
complex. Electronic health (eHealth) technology has the potential to
significantly improve the management of late effects for childhood
cancer survivors and assist their General Practitioners (GP) to
coordinate their care. We assessed the acceptability of and perceived
benefits and barriers to eHealth use amongst survivors, parents, and
GPs. Methods: We conducted semi-structured telephone interviews with
survivors of childhood cancer, parents of childhood cancer survivors and
their nominated GP. We described a hypothetical eHealth tool and asked
participants how likely they would use the tool to manage their
survivorship care and their perceived benefits and concerns for use of
the tool. We used content analysis to synthesise the data using QSR
NVivo12. Results: We interviewed 31 survivors (mean age: 27.0), 29
parents (survivors’ mean age: 12.6) and 51 GPs (mean years practising:
28.2). Eighty-five percent of survivors and parents (n=51), and 75% of
GPs (n=38) indicated that they would be willing to use an eHealth tool.
Survivors and parents reported that an eHealth tool would increase their
confidence in their ability, and their GP’s ability, to manage their
survivorship care. GPs agreed that an eHealth tool would provide easier
access to survivors’ medical information and increase their capacity to
provide support during survivorship. 7% of GPs (n= 4) and 43% of
survivors (n=26) reported being hesitant to use eHealth tools due to
privacy/security concerns. Conclusion: Overall, eHealth tools were
reported to be acceptable to childhood cancer survivors, their parents,
and their GPs.
Assessing local drivers influencing Land Use Cover Change (LUCC) in Southwestern Ghana: A Mixed-Method Approach (MMA) Analyses.
Authors: Sarfo Isaac , Shuoben Bi , Bortey Henry , Darko George , Kedjanyi Emmanuel , Oduro Collins , Folorunso Ewumi , Alriah Mohamed , Amankwah Solomon , Ndafira Grace
Published: April 2021

Changes in land cover have persisted throughout the history of mankind,
and are the direct and indirect consequence of human actions to secure
essential resources. Understanding direct and indirect factors that
influence land use cover change (LUCC) is essential for modelling future
LUCC in developing countries. The study analyses local drivers of LUCC
in Southwestern Ghana using the mixed-method approach. The approach
aided in identifying key drivers of LUCC, using different research
strategies for comparisons through confidence level analysis and
Analytic Hierarchy Process (AHP). We used expert interviews, literature
review and geostatistical tools to ascertain causative factors
triggering such unprecedented changes. Geospatial analysis depicted a
decline in forests (-1.65 km2yr-1.) and areas covered by water bodies
(-0.55 km2yr-1.). A remarkable increase in built-up (+25.77 km2yr-1.)
and farmlands/shrubs (+7.4km2yr-1.) areas were also observed. Population
growth, expansion of settlements and infrastructure, coupled with
agricultural expansion are at the centre of the LUCC-environment nexus,
based on the confidence level table. A steady increase in surface
temperature can be attributed to the unprecedented LUCC over the past 50
years. Socio-economic development in Southwestern Ghana is fuelling
interest in the relation between LUCC and environmental change.
Biophysical, cultural and technological factors are also considered key
drivers despite the “medium-to-very low confidence” in results
generated. They could potentially impact climate-sensitive sectors that
significantly modify land-use systems from the pessimists and optimist’s
perspective. We, therefore, propose further analyses of LUCC drivers
with medium to very low confidence levels.
Acid-base, electrolyte and oxidative status in dairy cows at different stages of the production cycle
Authors: Jovanovic Ljubomir , Nedic Sreten , Bosnjakovic Dusan , Milanovic Svetlana , Stojic Milica , Vujanac Ivan , Prodanovic Radisa , Kirovski Danijela
Published: April 2021

Previous studies in the field of acid-base and oxidative status in cows have mainly focused on the transition period (three weeks before and three weeks after calving). The aim of this study was to determine the differences in the parameters of acid-base and oxidative status and electrolyte balance in cows not only during the transition period, but also at other stages of the production cycle. Holstein-Friesian cows were divided into four numerically equal groups (n = 6): early lactating cows (9?2 days in milk - DIM), peak lactating cows (50?5 DIM), late lactating cows (170?10 DIM) and dry cows (10?1 days before calving). Venous blood samples were taken from the cows to analyze acid-base status, electrolyte concentrations and oxidative stress parameters, and to compare group means. Significantly higher pH was observed in early lactating cows than in late lactating cows. Sodium (Na+) concentration was significantly lower in early lactating and peak lactating cows compared to dry cows, while chloride (Cl-) concentration was also lower in late lactating cows compared to dry cows. Plasma glutathione peroxidase (GSH-Px) activity was higher in early lactating cows compared to peak lactating cows. Thus, the highest blood pH, lowest Na+ and Cl- concentrations and highest serum GSH-Px activity were observed in early lactating cows compared to other groups, indicating the highest metabolic and oxidative stress during this period. In conclusion, it would be useful to consider the inclusion of these parameters in standard health assessment procedures in intensive dairy production.
Estrategias didácticas a través de la realidad mixta para el aprendizaje teórico-práctico en estudiantes de educación media superior
Authors: Encarnación De Jesús Laura , Ayala Ramírez Suhey
Published: April 2021

Por las características que presenta, la realidad mixta es una tecnología prometedora dentro del sector educativo. El objetivo de esta investigación fue evaluar la influencia que tiene esta tecnología en el aprendizaje teórico-práctico de estudiantes de educación media superior. El enfoque fue de carácter mixto. Se apoyó de un pretest y postest para evaluar aprendizajes específicos de arquitectura de hardware. Asimismo, se apoyó de las aplicaciones Creator AVR y PC Building. Para evaluar la influencia de la realidad mixta, se utilizó el modelo de aceptación de tecnologías que evalúa los rubros de facilidad, usabilidad y utilidad. Como resultado general, se obtuvo 79.2 % de conocimientos teóricos-prácticos. En el indicador de utilidad, se obtuvo 87 %, en el de usabilidad 69 % y en el de facilidad de uso 65 %. El estudio permitió observar que el uso de la realidad mixta puede apoyar el aprendizaje teórico-práctico de los estudiantes.
Modern Approaches to Enteral Nutrition in Intensive Care
Authors: Potskhveriya M. M. , Goldfarb Yu. S. , Matkevich V. A. , Ryk A. A.
Published: April 2021

The analysis of the literature data allowed us to establish that today enteral nutrition (EN) is unanimously recognized by specialists as the preferred method of nutritional therapy, which significantly affects the course of critical conditions (CC). The use of EN now affects almost the entire nosology that forms the cohort of such patients. To the least extent, the scientific analysis of the possibilities of EN touched acute poisoning, where, given the special danger to life of their severe forms, there are great prospects for further research of this kind. It is especially emphasized that EN mainly in the first 24-48 hours from the onset of the disease mostly affects the achievement of positive results of treatment of CC, accompanied by an improvement in metabolic processes in organs and tissues. There is great interest in studying the pathogenesis of CC by assessing changes in homeostasis indicators using modern laboratory and instrumental control, which strengthens the scien-tific basis of EN. At the same time, it also contributes to the disclosure of his sanogenesis. Considering that, along with immunological shifts, the formation of oxidative stress and hemorheological disorders is of particular  importance in the pathogenesis of CC, being to a large extent involved in the development of endogenous intoxication and their irrevers-ibility, studies on EN in this field are promising, which, in our opinion, are still are very limited,  and in relation to hemorheology, according to the data available to us, are not represented at all. There are also no generalized up-to-date data on the economic component of EN. Further improvement of EN, as well as the  corresponding organizational measures, it seems, can bring this method to a  higher level of efficiency and, accordingly, safety, which, combined with the economic advantages of EN, will expand the possibilities of its  implementation in clinical practice.

AIM OF STUDY Standardization of staged treatment of patients with severe concomitant closed abdominal trauma.
Legal and Regulatory Framework for Provision of First Aid and Education in First Aid in Out-of-Hospital Cardiac Arrest
Authors: Birkun A. A. , Dezhurny L. I.
Published: April 2021

The likelihood of life recovery in out-of-hospital cardiac arrest (OHCA) critically depends on the speed of providing care. Basic bystander cardiopulmonary resuscitation in case of OHCA and automatic external defibrillation greatly increase the chances of survival. To ensure a high level of readiness of the population to provide first aid (FA), effective legal regulation is required. The article presents the results of a comprehensive analysis of the current regulatory legal acts of the Russian Federation governing the provision of FA in case of OHCA, as well as domestic and foreign scientific publications dedicated to legal support in the field of FA. In particular, the issues of protection of persons providing FA from legal liability in case of harm to the victim are discussed, the obligations established by the legislation to provide FA and train FA, suggestions are made to optimize the relevant legal framework in order to increase the efficiency of first aid for OHCA and reduce mortality from OHCA in Russia.
Cognitive-Emotional Music Listening Paradigm in Professional Music Education
Authors: Vidulin Sabina , Kazić Senad
Published: April 2021

Music education is an important factor of students’ development. The positive effect of music training is evident in all areas, from the intellectual, psychomotor to social and emotional ones, and therefore music classes in the music school should focus both on music making and on experience, understanding and evaluating music, as well as on expressing one’s own ideas, feelings and thoughts. In ear training classes it can be achieved through the area of music listening. Didactical initiatives of the 19th and 20th century contributed to the recognition of the advantages of the auditory approach, while technological innovations allowed the practical application of music listening. Although there are examples that point to fostering the emotional experience in music classes, music listening is still focused on giving assignments of cognitive type and learning about music components. Some exceptions pertain to the application of multimodality in music teaching using both musical and extra-musical areas. The paper is aimed at pointing to the value of the cognitive-emotional music listening and to the possibilities it opens in ear training classes. The cognitive-emotional music listening focuses on experiencing, understanding and appreciation of classical music aimed at shaping students’ worldview and improving their music competences. It can be achieved by the multimodal and interdisciplinary approach to a musical piece. Students learn about the musical-historical context of the emergence of a piece in a given time and circumstances, about the composing approach and the theoretical and harmony features of the work, they develop their musical and critical thinking, make music, and evaluate both music and their own achievements. Repeated listening to a musical piece or excerpts from it, observing and familiarizing with the piece from different perspectives and discussion about the piece and experience after listening make it possible to better understand the piece and its specifics, as well as to discover and improve one’s own self and accept others and the different.
Students’ Perception and Attitudes toward Faculty Image on Social Networks
Authors: Vukić Milena , Milićević Snežana , Vukić Ksenija , Vukić Milorad
Published: April 2021

Purpose of this paper is to determine how students perceive the image of their faculty on social networks, but also to analyse their experience and attitudes towards faculty social media strategy. The research was implemented using descriptive statistic techniques, as well as non-parametric tests such as Mann-Whitney U Test, Kruskal-Wallis H Test and Spearman’s Rho. The most common source of information when it comes to enrolment to faculty is word of mouth, while social media have a signifi-cantly lower credibility. During their schooling the respondents have most confidence in the official website, and far less in social networks. Such findings signalize the necessity of creating an adequate digital marketing strategy that can significantly improve the perceived faculty image. Positive perception of the image is fundamental for understanding the process of searching for and selection of the faculty, especially since the results have shown that the students do not value highly the image their faculties have on social networks. Positive perception of faculty image mostly depends on promotion strategy on Facebook and Insta-gram, and far less on LinkedIn and Twitter. In addition, students value more the image of the faculty whose social network pro-file they follow and, in a case, when they are followed back. No correlation was found between faculty image and gender, age or average grade. Therefore, we can conclude that social networks are very important in creating positive image and thanks to new technology, they are a promising solution for differentiation from competition in digital space.
Pelaksanaan fungsi pokok humas pemerintah pada lembaga pemerintah
Authors: Prastowo FX Ari Agung
Published: April 2021

Fungsi humas dalam sebuah lembaga dapat menjadi sarana untuk mengoptimalkan pelayanan publik khususnya dalam penyebaran informasi. Sehingga jika dilakukan secara optimal, fungsi humas dapat meningkatkan kinerja lembaga juga kepercayaan publik. Kendala dalam pelaksanaan fungsi humas pemerintah harus segera diminimalisir, agar tidak berakibat pada turunnya kepercayaan masyarakat kepada kinerja pemerintah yang berbasis pelayanan. Untuk itu, penelitian ini dilakukan untuk mengetahui: pelaksanaan fungsi pokok humas pemerintah pada lembaga pemerintah. Metode penelitian ini adalah deskriptif dengan analisis data kualitatif. Subjek penelitian ini adalah Pejabat Humas Pemerintah yang berasal dari beberapa lembaga diantaranya: (1) Kementerian Pendidikan Nasional; (2) Kementerian Komunikasi dan Informatika; (3) Kementerian Pendayagunaan Aparatur Negara dan Reformasi Birokrasi; (4) Kementerian Koordinator Politik, Hukum dan Keamanan. Data yang dikumpulkan dalam penelitian ini adalah data primer diperoleh dari hasil pengamatan dan wawancara mendalam. Hasil penelitian ini adalah terdapat tahapan yang dilakukan lembaga Pemerintah dalam pelaksanaan fungsi Humas sebagai saluran penyebar informasi. Informasi yang disampaikan harus valid dan jelas serta menggunakan media yang tepat. Peneliti merekomendasikan agar lembaga Pemerintah mengoptimalkan media online sebagai sarana untuk menyebarkan informasi pada publik. Begitu pula dengan pelaksanaan fungsi pelayanan publik. Humas Pemerintah sudah hakekatnya untuk menjalankan fungsi ini, maka sudah seharusnya lembaga Pemerintah bisa memberikan pelayanan prima pada masyarakat. Hal yang harus diperhatikan oleh praktisi Humas dalam pelaksanaan Fungsi pokok Humas Pemerintah sebagai fasilitator komunikasi antara lembaga dan masyarakat adalah dengan menggunakan komunikasi dua arah juga bertindak sebagai negosiator bukan hanya sebagai komunikator.
Avances en el desarrollo de una vacuna contra la malaria por Plasmodium falciparum: una revisión de literatura
Authors: Gómez Rodríguez Alida Marcela , Molina-Franky Jessica , Salamanca-Jiménez David , Reyes Santofimio Cesar
Published: April 2021

Introducción. La malaria por Plasmodium falciparum es una enfermedad causante de altas tasas de morbimortalidad a nivel mundial. Diferentes candidatos a vacuna se han evaluado experimentalmente en humanos; sin embargo, no se dispone de ninguna vacuna que reduzca o elimine esta devastadora enfermedad. Objetivo. Describir en términos de diseño, respuesta inmune, eficacia protectiva y perspectivas, los principales candidatos vigentes a vacuna contra la malaria por Plasmodium falciparum, dirigidos a las fases pre-eritrocítica y eritrocítica. Metodoogía. Se realizó una revisión descriptiva de trabajos publicados en bases de datos PubMed, Science Direct, Embase y MedLine. Los criterios de inclusión fueron: trabajos publicados en una ventana de tiempo entre 2000 y 2019, candidatos a vacuna contra Plasmodium falciparum en estadíos pre y eritrocíticos y vigencia según la Organización Mundial de la Salud. En total, se revisaron 90 artículos originales, encontrando que 63 cumplieron con todos los criterios establecidos, mientras que 27, no cumplieron por lo menos con un criterio. Resultados. Los candidatos a vacunas vigentes incluyen diseños basados en parásitos atenuados, proteínas recombinantes, vectores virales y síntesis química. Las formulaciones contienen un número mínimo de antígenos con secuencias de aminoácidos altamente polimórficas, que inducen un aceptable perfil de inmunogenicidad, aunque una limitada eficacia protectora contra la malaria, debido a que tales regiones polimórficas son inmunodominantes, confiriendo únicamente inmunidad específica de cepa. Conclusión. El desarrollo de una vacuna efectiva contra la malaria por Plasmodium falciparum posiblemente requiera incluir múltiples epítopes funcionalmente relevantes, del estadío pre y eritrocítico, que contengan regiones conservadas entre cepas, para lograr inducir respuestas inmunes duraderas que bloqueen la invasión del parásito a células hepáticas y eritrocitos.