bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioinspired Remineralization of Artificial Caries Lesions Using PDMAEMA/Carbomer/Calcium Phosphates Hybrid Microgels
Authors: Bonchev Alexander , Simeonov Marin , Shestakova Pavletta , Vasileva Radosveta , Titorenkova Rositsa , Apostolov Anton , Dyulgerova Elena , Vassileva Elena
Published: October 2022

Dental caries remains one of the most prevalent bacterium-caused chronic diseases affecting both adults and children worldwide. The development of new materials for enhancing its remineralization is one of the most promising approaches in the field of advanced dental materials as well as one of the main challenges in non-invasive dentistry. The aim of the present study is to develop novel hybrid materials based on (PDMAEMA)/Carbomer 940 microgels with in situ deposited calcium phosphates (CaP) and to reveal their potential as a remineralization system for artificial caries lesions. To this purpose, novel PDMAEMA/Carbomer 940 microgels were obtained and their core–shell structure was revealed by transmission electron microscopy (TEM). They were successfully used as a matrix for in situ calcium phosphate deposition, thus giving rise to novel hybrid microgels. The calcium phosphate phases formed during the deposition process were studied by X-ray diffraction and infrared spectroscopy, however, due to their highly amorphous nature, the nuclear magnetic resonance (NMR) was the method that was able to provide reliable information about the formed inorganic phases. The novel hybrid microgels were used for remineralization of artificial caries lesions in order to prove their ability to initiate their remineralization. The remineralization process was followed by scanning electron microscopy (SEM), X-ray diffraction, infrared and Raman spectroscopies and all these methods confirmed the successful enamel rod remineralization upon the novel hybrid microgel application. Thus, the study confirmed that novel hybrid microgels, which could ensure a constant supply of calcium and phosphate ions, are a viable solution for early caries treatment.
Thermo-/pH-Dual-Sensitive PEG/PAMAM Nanogel: Reaction Dynamics and Plugging Application of CO2 Channeling
Authors: Liu Xiangbin , Wang Suling , Shi Weiguang , Liu He
Published: October 2022

Smart hydrogels, owing to their exceptional viscoelastic and deformable capacity in response to environmental stimulation involving temperature and pH, have been successfully applied in oilfields for purposes such as water and/or gas shutoff treatments. However, the CO2 breakthrough problem in low permeability reservoirs has not been well solved. In this work, a rheological method-based Avrami dynamics model and Dickinson dynamics model were employed to investigate the dynamic gelation process of thermo-/pH-dual-sensitive PEG/PAMAM nanogels to further our understanding of the microstructure of their gelation and pertinence plugging application. Plugging experiments were performed by alternating injections of CO2 and hydrogel solution in a slug type on three fractured low permeability cores with a backpressure of 13 MPa. The nanogels presented a secondary growth pattern from three to one dimension from micrometer to nanometer size with a morphological transformation from a sphere to an irregular ellipsoid or disk shape. The phase transition temperature was 50 °C, and the phase transition pH was 10. If both or either were below these values, the hydrogel swelled; otherwise, it shrank. Plugging results show that the plugging efficiency was higher than 99%. The maximum breakthrough pressure was 19.93 MPa, and the corresponding residual pressure remained 17.64 MPa for a 10 mD core, exhibiting great plugging performance and high residual resistance after being broken through by CO2.
Theory Designed Strategies to Support Implementation of Genomics in Nephrology
Authors: Kansal Arushi , Quinlan Catherine , Stark Zornitza , Kerr Peter G. , Mallett Andrew J. , Lakshmanan Chandni , Best Stephanie , Jayasinghe Kushani
Published: October 2022

(1) Background: Genomic testing is increasingly utilized as a clinical tool; however, its integration into nephrology remains limited. The purpose of this study was to identify barriers and prioritize interventions for the widespread implementation of genomics in nephrology. (2) Methods: Qualitative, semi-structured interviews were conducted with 25 Australian adult nephrologists to determine their perspectives on interventions and models of care to support implementation of genomics in nephrology. Interviews were guided by a validated theoretical framework for the implementation of genomic medicine—the Consolidated Framework of Implementation Research (CFIR). (3) Results: Nephrologists were from 18 hospitals, with 7 having a dedicated multidisciplinary kidney genetics service. Most practiced in the public healthcare system (n = 24), a large number were early-career (n = 13), and few had genomics experience (n = 4). The top three preferred interventions were increased funding, access to genomics champions, and education and training. Where interventions to barriers were not reported, we used the CFIR/Expert Recommendations for Implementing Change matching tool to generate theory-informed approaches. The preferred model of service delivery was a multidisciplinary kidney genetics clinic. (4) Conclusions: This study identified surmountable barriers and practical interventions for the implementation of genomics in nephrology, with multidisciplinary kidney genetics clinics identified as the preferred model of care. The integration of genomics education into nephrology training, secure funding for testing, and counselling along with the identification of genomics champions should be pursued by health services more broadly.
Partial Disturbance of Microprocessor Function in Human Stem Cells Carrying a Heterozygous Mutation in the DGCR8 Gene
Authors: Reé Dóra , Fóthi Ábel , Varga Nóra , Kolacsek Orsolya , Orbán Tamás I. , Apáti Ágota
Published: October 2022

Maturation of microRNAs (miRNAs) begins by the “Microprocessor” complex, containing the Drosha endonuclease and its partner protein, "DiGeorge Syndrome Critical Region 8" (DGCR8). Although the main function of the two proteins is to coordinate the first step of precursor miRNAs formation, several studies revealed their miRNA-independent functions in other RNA-related pathways (e.g., in snoRNA decay) or, for the DGCR8, the role in tissue development. To investigate the specific roles of DGCR8 in various cellular pathways, we previously established a human embryonic stem-cell (hESC) line carrying a monoallelic DGCR8 mutation by using the CRISPR-Cas9 system. In this study, we genetically characterized single-cell originated progenies of the cell line and showed that DGCR8 heterozygous mutation results in only a modest effect on the mRNA level but a significant decrease at the protein level. Self-renewal and trilineage differentiation capacity of these hESCs were not affected by the mutation. However, partial disturbance of the Microprocessor function could be revealed in pri-miRNA processing along the human chromosome 19 miRNA cluster in several clones. With all these studies, we can demonstrate that the mutant hESC line is a good model to study not only miRNA-related but also other “noncanonical” functions of the DGCR8 protein.
An Explanation of Exceptions from Chargaff’s Second Parity Rule/Strand Symmetry of DNA Molecules
Authors: Rosandić Marija , Vlahović Ines , Pilaš Ivan , Glunčić Matko , Paar Vladimir
Published: October 2022

In this article, we show that mono/oligonucleotide quadruplets, as basic structures of DNA, along with our classification of trinucleotides, disclose an organization of genomes based on purine–pyrimidine symmetry. Moreover, the structure and stability of DNA are influenced by the Watson–Crick pairing and the natural law of DNA creation and conservation, according to which the same mono- or oligonucleotide insertion must be inserted simultaneously into both strands of DNA. Taken together, they lead to quadruplets with central mirror symmetry and bidirectional DNA strand orientation and are incorporated into Chargaff’s second parity rule (CSPR). Performing our quadruplet frequency analysis of all human chromosomes and of Neuroblastoma BreakPoint Family (NBPF) genes, which code Olduvai protein domains in the human genome, we show that the coding part of DNA violates CSPR. This may shed new light and give rise to a novel hypothesis on DNA creation and its evolution. In this framework, the logarithmic relationship between oligonucleotide order and minimal DNA sequence length, to establish the validity of CSPR, automatically follows from the quadruplet structure of the genomic sequence. The problem of the violation of CSPR in rare symbionts is discussed.
The Impact of TSC-1 and -2 Mutations on Response to Therapy in Malignant PEComa: A Multicenter Retrospective Analysis
Authors: Liu Lawrence , Dehner Carina , Grandhi Nikhil , Lyu Yang , Borcherding Dana C. , Chrisinger John S. A. , Zhang Xiao , Luo Jingqin , Tao Yu , Parkes Amanda , Bui Nam Q. , Davis Elizabeth J. , Milhem Mohammed M. , Monga Varun , Weiss Mia , Tine Brian Van , Hirbe Angela C.
Published: October 2022

Background: Perivascular epithelioid cell neoplasms (PEComas) are a diverse family of mesenchymal tumors with myomelanocytic differentiation that disproportionately affect women and can be associated with tuberous sclerosis (TS). Although mTOR inhibition is widely used as first-line treatment, it is unclear what genomic alterations exist in these tumors and how they influence the response to therapy. Methods: This was a multicenter study conducted at five sites within the US. The data were collected from 1 January 2004 to 31 January 2021. We conducted a retrospective analysis to identify PEComa patients with next-generation sequencing (NGS) data and compared outcomes based on mutations. Results: No significant differences in survival were identified between TSC-1 and TSC-2 mutated PEComa or TSC-1/-2 versus other mutations. No significant difference was seen in progression-free survival (PFS) after first-line therapy between mTOR inhibition versus other systemic therapies. Conclusions: We were unable to detect differences in survival based on genomic alterations or PFS between mTOR inhibition versus other systemic therapies. Future studies should seek to identify other drivers of TSC-1/-2 silencing that could predict response to mTOR inhibition.
Circulating mtDNA and Impaired Intestinal Barrier after Gastrointestinal Surgery Are Correlated with Postoperative SIRS
Authors: Kong Can , Song Wei , Ren Jun , Zhou Dingshan , Li Jiazheng , Xiang Renshen , Fu Tao
Published: October 2022

Background: This prospective study aimed to explore the correlation between circulating mitochondrial DNA (mtDNA), intestinal barrier function impairment, and postoperative SIRS in patients undergoing gastrointestinal surgery. Methods: Patients were recruited into this study after signing an informed consent form. Circulating mitochondrial DNA and serum DAO concentrations were measured preoperatively and on day 1 and day 7 postoperatively. Postoperative vitals, routine tests, and biochemical indicators were recorded in detail. Results: Forty patients undergoing gastrointestinal surgery were recruited for and completed this study. Patients were divided into non-fever, fever, and SIRS groups according to their postoperative temperature and other corresponding indexes. The mtDNA was expressed as the number of PCR cycles using three specific sequences. Circulating mtDNA tended to increase in patients after gastrointestinal surgery, but the difference was not significant. Nevertheless, mtDNA in the SIRS group was significantly higher than in patients in the fever and non-fever groups (p < 0.05). Serum DAO showed a trend of increase on the first day after surgery compared with that before surgery, but the difference was not significant (p > 0.05). However, patients in the SIRS group showed a significant increase (p < 0.05) compared with the others. Both circulating mtDNA and DAO showed a downward trend on the seventh day after surgery. Conclusions: Circulating mtDNA presented a trend of increase after gastrointestinal surgery, and the degree of the increased fold was related to the extent of the inflammation response. In general, the intestinal barrier damage indicator DAO was the same as mtDNA and tended to increase after gastrointestinal surgery and then gradually decrease, which may play a synergistic role in inducing postoperative fever and SIRS.
Presence, Absence, Transience: The Spatiotemporalities of Sand
Authors: Knight Jasper
Published: October 2022

Sand grains are ubiquitous in the Earth’s system, and are found in different environmental settings globally, but sand itself as a physical object has multiple conflicting meanings with respect to both its agglomeration into landforms such as sand dunes and beaches, and how sand and its dynamics have cultural significance and meaning. This study takes a transdisciplinary approach towards examining the multiple meanings of sand, focusing on sand as a spatiotemporal pheneomenon that exists in different contexts within the Earth system. The nature and spatiotemporalities of sand are framed in this study through the concepts of presence, absence and transience, which are key interpretive approaches that lie at the interface of how the physical and phenomenological worlds interact with each other. This is a new and innovative approach to understanding people–environment relationships. These concepts are then discussed using the examples of the dynamics of and values ascribed to desert dune and sandy beach landscapes, drawn from locations globally. These examples show that the dynamic geomorphic changes taking place in sand landscapes (sandscapes) by erosion and deposition (determining the presence and absence of sand in such landscapes) pose challenges for the ways in which people make sense of, locate, interact with and value these landscapes. This uncertainty that arises from constant change (the transience of sandscapes) highlights the multiple meanings that sandscapes can hold, and this represents the comforting yet also unsettling nature of sand, as a vivid symbol of human–Earth relationships.
Structurally Controlled Landscape Evolution in Kula Badlands, Western Turkey
Authors: Aksay Selçuk , Schoorl Jeroen M. , Veldkamp Antonie , Demir Tuncer , Aytaç Ahmet Serdar , Maddy Darrel
Published: October 2022

Badlands are extensively eroded landscapes consisting of weakly consolidated deposits within highly dense drainage systems. Their controlling and shaping factors can differ in relation to various internal and external conditions and processes that are not always well understood. This study focuses on the development of a badland landscape affecting Miocene and Quaternary sand-clay sediments in the extensional tectonic regime of Western Turkey with a multidisciplinary approach. The area between Kula and Selendi towns exhibits a badland topography with extensively eroded surface features, deepened gullies within poorly consolidated, sand clay-sized sediments. The results of structural field mapping and morphometric analyses using a 5 m resolution DEM to study the role of structural control in the development of badlands are presented in this study. Field data analysis supported by the quantitative assessment of longitudinal gully profiles illustrates the role of pre-existing structures as faults, their orientation and geometry in net erosion-sedimentation and the development of deepened gully networks. Representative illustrations, field photographs and block diagrams are presented to show the relationship between the rock structure and badland landscape. The connection between the extensional tectonics, erosional dynamics and geomorphology point to a structurally-controlled landscape in the Kula badlands in Western Turkey.
The Work of a Moment: When Jane Austen Stops Time
Authors: Frawley Maria
Published: October 2022

This essay examines Jane Austen’s occasional but potent attention to singular moments that seem to stand outside of the usual flow of time. Signaled by her use of phrases such as ‘the work of a moment’ or ‘the work of an instant’, these momentous moments gain resonance when studied against the backdrop of Austen’s nuanced attention to temporal representation in narrative and to the temporal dimensions of human experience. The essay argues that Austen’s momentous moments ultimately function as a crucial dimension of what Amit Yahav in Feeling Time designates the ‘sensibility chronotope’, a perspective that asserts primacy over chronometry and chronology. Attending to these moments in the fiction further enables us to assess Austen’s contribution to what would later become a distinctive feature of the nineteenth-century realist novel, the preoccupation with roads not taken and ‘lives unled’, as Andrew Miller argues in On Not Being Someone Else: Tales of Our Unled Lives.
Religious Affiliation and Flu Vaccination in Germany: Results of the German Ageing Survey
Authors: Shaheen Hamzah , König Hans-Helmut , Hajek André
Published: October 2022

Our aim was to examine the association between religious affiliation and the likelihood of taking the flu vaccine. Cross-sectional data (year 2014 with n = 7172) were used from the nationally representative German Ageing Survey—covering community-dwelling individuals aged 40 years and over. Multiple logistic regressions showed that compared with individuals without a religious affiliation, individuals with certain religious affiliations had a lower likelihood of taking the flu vaccine. More precisely, the likelihood of taking a flu shot was significantly associated with belonging to the Roman Catholic Church (OR: 0.50, 95% CI: 0.44–0.57), the Protestant Church (OR: 0.68, 0.60–0.77), the Evangelic Free Church (OR: 0.54, 0.35–0.82) and other religious communities (OR: 0.25, 0.14–0.45). The results remained nearly the same when we restricted our analyses to individuals aged 60 years and over (according to existing recommendations for flu vaccination). The association between religious affiliation and the likelihood of taking the flu vaccine was moderated by thoughts about religion and deeds for religion. This knowledge could help to improve the immunization coverage by addressing individuals with certain religious affiliations.
A New Architecture for Customizable Exergames: User Evaluation for Different Neuromuscular Disorders
Authors: Eckert Martina , Aglio Alicia , Martín-Ruiz María-Luisa , Osma-Ruiz Víctor
Published: October 2022

This paper presents a modular approach to generic exergame design that combines custom physical exercises in a meaningful and motivating story. This aims to provide a tool that can be individually tailored and adapted to people with different needs, making it applicable to different diseases and states of disease. The game is based on motion capturing and integrates four example exercises that can be configured via our therapeutic web platform “Blexer-med”. To prove the feasibility for a wide range of different users, evaluation tests were performed on 14 patients with various types and degrees of neuromuscular disorders, classified into three groups based on strength and autonomy. The users were free to choose their schedule and frequency. The game scores and three surveys (before, during, and after the intervention) showed similar experiences for all groups, with the most vulnerable having the most fun and satisfaction. The players were motivated by the story and by achieving high scores. The average usage time was 2.5 times per week, 20 min per session. The pure exercise time was about half of the game time. The concept has proven feasible and forms a reasonable basis for further developments. The full 3D exercise needs further fine-tuning to enhance the fun and motivation.
Effect of Exogenous Calcium on the Heat Tolerance in Rosa hybrida ‘Carolla’
Authors: Wang Han , Shen Yuxiao , Wang Kaixuan , He Songlin , Kim Wan-Soon , Shang Wenqian , Wang Zheng , Shi Liyun
Published: October 2022

This study was designed to investigate the effects of exogenous calcium on the tolerance of Rosa hybrida ‘Carolla’ to high-temperature and the physiological mechanisms underlying this response. Leaves of ‘Carolla’ grown under stress were treated by spraying four different concentrations of calcium chloride (CaCl2; 50, 100, 150, or 200 μM). The photosynthetic responses, antioxidant enzyme activities, and osmotic substance contents were measured under high-temperature stress at the flowering stage. Temperature-stressed ‘Carolla’ with CaCl2 treatment showed significantly increased chlorophyll (Chl) content, net photosynthetic rate (An), transpiration rate (E), stomatal conductance (gs), water use efficiency (WUE), superoxide dismutase (SOD), peroxidase (POD), and ascorbate peroxidase (APX) activities together with proline (Pro), soluble sugar (SS), and soluble protein (SP) concentrations, while malonaldehyde (MDA) content and relative electrical conductivity (REC) were significantly reduced. The damages caused by high-temperature stress were alleviated by applying CaCl2. Among the CaCl2 treatments, 100 μM CaCl2 best minimized the damage caused by high-temperature to ‘Carolla’. This study showed that exogenous calcium could improve the tolerance of Rosa hybrida ‘Carolla’ to high-temperature stress by regulating photosynthesis, the antioxidant system, and osmotic substances.
Ethnic Differences in Socioeconomic and Health Determinants Related to Self-Rated Health Status: A Study on Community-Dwelling Israeli Jews and Arabs in Old Age
Authors: Rozani Violetta
Published: October 2022

Self-rated health (SRH) is widely used as a proxy for general health status. In old age, SRH has been found to be a strong predictor of morbidity, physical functioning, recovery from illness, use of health services, and mortality. This study was designed to examine differences in socioeconomic and health determinants related to self-rated health status among community-dwelling Jews and Arabs aged 65+ years. Cross-sectional data from 2011 on such Jews and Arabs were extracted from reprehensive National Surveys. The association between socioeconomic and health factors with poor SRH was estimated using three hierarchical logistic regression models. The majority of the respondents were Jews (86%), with a mean age of 73.1 (±6.3) years. The study revealed that older Arabs are disadvantaged according to almost every socioeconomic and health indicator compared to Jews. Poor SRH was significantly associated with age (OR = 1.03, p = 0.002), ethnicity (Jews OR = 2.62, p < 0.001), unemployment/retirement (OR = 2.03, p < 0.001), low income (OR = 3.03, p < 0.001), low education (OR = 1.37, p = 0.013), absence of physical activity (OR = 2.17, p < 0.001), dentures (OR = 1.40, p = 0.002), and prevalence of one or more chronic diseases (OR = 4.06, p < 0.001). The findings therefore indicated that these factors need to be detected and focused on by health professionals in order to improve the population’s general health status.
Factors Affecting the Use of Private Outpatient Services among the Adult Population in Malaysia
Authors: Anis-Syakira Jailani , Jawahir Suhana , Abu Bakar Nurul Salwana , Mohd Noh Sarah Nurain , Jamalul-Lail Nurul Iman , Hamidi Normaizira , Sararaks Sondi
Published: October 2022

The proportion of Malaysians of all ages who use private outpatient services has dropped over time, highlighting the overstretched condition of public outpatient facilities compared to their private counterparts. This paper aims to determine the prevalence of outpatient care, characteristics of outpatient care users by sector, and the factors affecting the utilisation of private outpatient services among the adult population of Malaysia using Andersen’s behavioural model. Data from the National Health Morbidity Survey 2019 (NHMS 2019), a nationwide survey, were analysed. Logistic regression analysis was performed to explore the association of predisposing (locality, age, sex, ethnicity, education level, and marital status), enabling (working status, health care coverage, and household income), and need factors (perceived and evaluated needs) with the use of private outpatient services. Variables with a statistical significance ≤ 0.25 in the univariate regression analysis were included in the final multivariable logistic regression analysis. A total of 11,674 respondents, estimated to represent 22.4 million adults aged 18 years and above in Malaysia, were included for analysis. Overall, 8.3% of the adult population of Malaysia used outpatient care and 33.9% used the private sector. Those living in urban areas (OR = 1.80, 95% CI = 1.02, 3.18), non-Malays (OR = 1.74, 95% CI = 1.04, 2.93), those working (OR = 2.47, 95% CI = 1.48, 4.10), those with employer coverage (OR = 4.73, 95% CI = 2.79, 8.01), and those with health problems (OR = 2.26, 95% CI = 1.26, 4.05) were more likely to utilise private outpatient services. Those who self-rated their health status as fair (OR = 0.54, 95% CI = 0.33, 0.91) and who had diabetes, hypertension, or hypercholesterolemia (OR = 0.56, 95% CI = 0.31, 1.02) were less likely to utilise private outpatient services. The predisposing and enabling factors were associated with the use of private outpatient services, and the need factors were strong predictors of private outpatient care utilisation among adults. Understanding the factors associated with the utilisation of private outpatient services could aid in the development of effective initiatives designed to enhance outpatient care access among the population of Malaysia and balance the burden of outpatient care provision on the public and private sector.
Care Staff’s Daily Living Decision-Making Support Scale for Older Adults with Dementia in Japan: Development of Validity and Reliability
Authors: Suzuki Mizue , Kanamori Takuya , Koide Yukio , Asai Yatami , Sato Masako , Naito Tomoyoshi , Inagaki Keigo , Kanamori Masao
Published: October 2022

This study aimed to develop and validate a scale to assess the daily-living decision-making support of care staff for older adults with dementia (OwDs) in Japan. A questionnaire survey was conducted among 138 care staff at two geriatric healthcare facilities from February to March 2021. The Daily Living Decision-Making Support Scale for Older Adults with Dementia (DL-DM) was developed using item analysis, factor analysis, and covariance structure analysis. The factor analysis yielded 12 items and three factors: (1) support for the formation and expression of intentions in daily life based on the life background and values of OwDs; (2) attitudes and devising ways to communicate regarding the formation and expression of intentions in OwDs daily lives; and (3) devising ways to support OwDs in realizing their intentions in daily life. The internal consistency reliability analysis yielded a Cronbach’s α of 0.87 for the total scale. The DL-DM correlated with the concurrent validity measures as expected. The DL-DM demonstrated validity and reliability as a potential scale to assess support for OwDs in daily life decision-making. The results also suggest an association between the DL-DM and person-centered care for OwDs.
Meanings and Practices in Intercultural Health for International Migrants
Authors: Cruz-Riveros Consuelo , Urzúa Alfonso , Macaya-Aguirre Gustavo , Cabieses Báltica
Published: October 2022

In this article, meanings and practices in intercultural health for international migrants in health establishments are described from the perspective of health personnel in the city of Antofagasta in northern Chile. Methodology: The methodology was qualitative with a phenomenological descriptive design, through which discourses from health personnel in the public primary and secondary care system were explored (n = 23). Next, meanings and practices in intercultural health for international migrants in health establishments are described from the perspective of health personnel in the northern Chilean city of Antofagasta. Results: The participants presented trees of thematic categories. There were three thematic categories overall: (1) The meaning of interculturality included features of understanding of the concept, with respect for culture being the transversal axis in all discourses. (2) Practices in health care, where voluntariness, references, and the adequacy or non-technicality of the language are fundamental axes. (3) Training in the intercultural approach, where there is often self-knowledge and lack of supply in the health system. Conclusions: The findings show essential elements to consider in the care of international migrants, including the training and awareness of staff about the intercultural approach through strategies following the local reality in which each health establishment exists.
Reskilled and Integrated, but How? Navigating Trauma and Temporary Hardships
Authors: Aydiner Cihan , Rider Erin L.
Published: October 2022

Immigrants are often pressed to show how they will contribute to a host country, thus proving through their conditions of entry and human capital whether they will be perceived as an asset or burden, and this is juxtaposed with the host country’s institutions offering an improved quality of life, mainly through employment. Seeking employment is often a key factor to be economically assimilated, and in the case of highly educated Turkish migrants, the opportunity to reclaim their previous professional and quality of life statuses. Based on qualitative research, we have examined the experiences of highly educated Turkish people (n = 42) in the recently forced migrant population. Following events including terrorism and the coup on 15 July 2016, Türkiye experienced the highest forced migration in her history. With exiled Turkish migrants, the forced aspect of their migration prompts them to seek a host country that provides safety, and they are also driven to transfer their educational degrees and professional credentials. However, changing careers to become educated and certified in new fields takes time and resources, contributing to a fluctuating economic status and loss of well-being. Once this is regained, their economic situation is improved, but there is still the lost time from the immigration and transfer period. Thus, the process has positive and negative components, but understanding this nuanced process provides opportunities for policy reform that can shorten the time of re-education, increase employability, and support well-being.
Residential Proximity to Urban Play Spaces and Childhood Overweight and Obesity in Barcelona, Spain: A Population-Based Longitudinal Study
Authors: Sánchez-Valdivia Nacho , Pérez-del-Pulgar Carmen , de Bont Jeroen , Anguelovski Isabelle , López-Gay Antonio , Pistillo Andrea , Triguero-Mas Margarita , Duarte-Salles Talita
Published: October 2022

Findings on the relationship between play spaces and childhood overweight and obesity are mixed and scarce. This study aimed to investigate the associations between residential proximity to play spaces and the risk of childhood overweight or obesity and potential effect modifiers. This longitudinal study included children living in the city of Barcelona identified in an electronic primary healthcare record database between 2011 and 2018 (N = 75,608). Overweight and obesity were defined according to the WHO standards and we used 300 m network buffers to assess residential proximity to play spaces. We calculated the risk of developing overweight or obesity using Cox proportional hazard models. A share of 29.4% of the study population developed overweight or obesity, but we did not find consistent associations between play space indicators and overweight or obesity. We did not find any consistent sign of effect modification by sex, and only some indications of the modifying role of area socioeconomic status and level of exposure. Although it is not possible to draw clear conclusions from our study, we call for cities to continue increasing and improving urban play spaces with an equitable, healthy, and child-friendly perspective.
The Health Effects of Real-World Dual Use of Electronic and Conventional Cigarettes versus the Health Effects of Exclusive Smoking of Conventional Cigarettes: A Systematic Review
Authors: Pisinger Charlotta , Rasmussen Sofie K. Bergman
Published: October 2022

Background: A high prevalence of dual use of e-cigarettes and conventional cigarettes has been reported across the world. Methods: A systematic search was carried out. We included original articles on any topic relevant to health, excluding mental health, in all languages. The PRISMA guidelines were followed. Both reviewers independently screened and read all publications. We compared dual use with exclusive smoking of conventional cigarettes (ESCC). Results: Fifty-two publications (49 studies) were included. Thirteen papers/10 studies were prospective. There was great heterogeneity across studies. Many methodological weaknesses, such as inaccurate exposure measurement, lack of adjustment for former tobacco consumption, and lack of significance testing were identified. Most prospective studies found dual use to be at least as harmful as ESCC. The longest follow-up was six years. Most of the best available cross-sectional studies found dual use associated with the same and, in several studies, significantly higher risk of self-reported symptoms/disease than in ESCC. The intensity of cigarette smoking seems associated with worse health. Conclusion: Existing studies indicate that dual use is at least as, or probably even more, harmful than ESCC. Due to the predominance of cross-sectional studies and the methodological weaknesses we judged the overall certainty of the evidence as “low certainty”.
Characteristics of Artificial Intelligence Clinical Trials in the Field of Healthcare: A Cross-Sectional Study on ClinicalTrials.gov
Authors: Wang Anran , Xiu Xiaolei , Liu Shengyu , Qian Qing , Wu Sizhu
Published: October 2022

Artificial intelligence (AI) has driven innovative transformation in healthcare service patterns, despite a lack of understanding of its performance in clinical practice. We conducted a cross-sectional analysis of AI-related trials in healthcare based on ClinicalTrials.gov, intending to investigate the trial characteristics and AI’s development status. Additionally, the Neo4j graph database and visualization technology were employed to construct an AI technology application graph, achieving a visual representation and analysis of research hotspots in healthcare AI. A total of 1725 eligible trials that were registered in ClinicalTrials.gov up to 31 March 2022 were included in this study. The number of trial registrations has dramatically grown each year since 2016. However, the AI-related trials had some design drawbacks and problems with poor-quality result reporting. The proportion of trials with prospective and randomized designs was insufficient, and most studies did not report results upon completion. Currently, most healthcare AI application studies are based on data-driven learning algorithms, covering various disease areas and healthcare scenarios. As few studies have publicly reported results on ClinicalTrials.gov, there is not enough evidence to support an assessment of AI’s actual performance. The widespread implementation of AI technology in healthcare still faces many challenges and requires more high-quality prospective clinical validation.
The Spatial Effect of Air Pollution Governance on Labor Productivity: Evidence from 262 Chinese Cities
Authors: Ren Fei , Zhu Yuke , Le Dong
Published: October 2022

According to epidemiological studies, air pollution can increase the rate of medical visits and morbidity. Empirical studies have also shown that air pollutants are toxic to animals. Using data from 262 Chinese cities for the period 2005 to 2018, this study systematically investigated the spatial spillover effect and transmission mechanism of air pollution governance on urban labor productivity. In this study, we also explored the changing trend of labor productivity in China from a dynamic perspective. Additionally, we selected the air flow coefficient and environmental regulations as two instrumental variables of air pollution governance to effectively alleviate endogenous problems existing in the model. The results show that air pollution governance plays a significant role in promoting the improvement of labor productivity. The effect of air pollution governance on labor productivity in eastern cities is better than that in central and western cities, and its effect in developed cities is better than that in undeveloped cities. With the increased intensity of air pollution governance, its effect on labor productivity is also strengthened. Urban innovation capacity and residents’ health are important channels for air pollution governance in the promotion of labor productivity. Finally, this study proposes policy recommendations, such as implementing a joint prevention and governance mechanism, as well as improving air pollution prevention and government regulations.
The Perception of Health Professionals in Bangladesh toward the Digitalization of the Health Sector
Authors: Hossain Md Shakhawat , Syeed M. M. Mahbubul , Fatema Kaniz , Uddin Mohammad Faisal
Published: October 2022

Bangladesh is undertaking a major transformation towards digitalization in every sector, and healthcare is no exception. Digitalization of the health sector is expected to improve healthcare services while reducing human effort and ensuring the satisfaction of patients and health professionals. However, for practical and successful digitalization, it is necessary to understand the perceptions of health professionals. Therefore, we conducted a cross-sectional survey in Bangladesh to investigate health professionals’ perceptions in relation to various socio–demographic variables such as age, gender, location, profession and institution. We also evaluated their competencies, as digital health-related competencies are required for digitalization. Additionally, we identified major digitalization challenges. Quantitative survey data were analyzed with Python Pandas, and qualitative data were classified using Valence-Aware Dictionary and Sentiment Reasoner (VADER). This study found significant relationships between age χ2(12,N=701)=82.02,p<0.001; location χ2(4,N=701)=18.78,p<0.001; and profession χ2(16,N=701)=71.02,p<0.001; with technical competency. These variables also have similar influences on psychological competency. According to VADER, 88.1% (583/701) of respondents have a positive outlook toward digitalization. The internal consistency of the survey was confirmed by Cronbach’s alpha score (0.746). This study assisted in developing a better understanding of how professionals perceive digitalization, categorizes professionals based on competency, and prioritizes the major digitalization challenges.
The Effect of Depressive and Insomnia Symptoms in Quality of Life among Community-Dwelling Older Adults
Authors: Tsaras Konstantinos , Tsiantoula Maria , Papagiannis Dimitrios , Papathanasiou Ioanna V. , Chatzi Maria , Kelesi Martha , Kaba Evridiki , Fradelos Evangelos C.
Published: October 2022

The purpose of this study was to investigate the effects of depressive symptoms, insomnia symptoms, and comorbid depressive and insomnia symptoms on the quality of life among community-dwelling older adults in an urban area of central Greece. A cross-sectional study was conducted on 200 older adults (aged ≥ 60) collected from five Open Care Centers for Elderly People of the Municipality of Larissa, Greece. Data were obtained through a questionnaire that included demographic, socioeconomic, and health-related characteristics; the World Health Organization Quality of Life (WHOQoL)-Bref questionnaire; the Geriatric Depression Scale; and the Athens Insomnia Scale. The prevalences of depression, insomnia, and comorbid depression and insomnia were 28% (95% confidence interval (95% CI): 21.8–34.2%), 40.5% (95% CI: 33.7–47.3%), and 19% (95% CI: 13.5–24.5%), respectively. The mean WHOQoL-Bref score for all domains was approximately 14.50, with the highest mean value observed for psychological health (14.79 ± 2.60), followed by the physical health (14.49 ± 2.66), social relationships (14.39 ± 2.03), and environmental domains (14.32 ± 1.90). All WHOQoL-Bref domains were negatively correlated with depression and insomnia. Older adults with depressive symptoms, insomnia symptoms, and comorbid depressive and insomnia symptoms had lower scores in all quality of life dimensions compared with those without.
Effect of Academic Self-Efficacy and Career Decision Level on Career Preparation Behavior of South Korean College Students
Authors: Kim Hyemin , Ra Young-An
Published: October 2022

The purpose of this study was to examine the mediating role of the career decision level (decidedness and comfort) of South Korean college students regarding the relationships between academic self-efficacy and career preparation behavior. For this purpose, the study collected and analyzed data on 296 South Korean college students using SPSS 22.0 and Hayes’ (2013) Process Macro tool. The results of the study are as follows. Academic self-efficacy was positively associated with career decision level and career preparation behavior, and career decision level was positively associated with career preparation behavior. In terms of the mediation effect, the career decision level partially mediated the relationships between academic self-efficacy and career preparation behavior. The results of the study provide useful suggestions for interventions in the career counseling of college students.
Simulation on the Permeability Evaluation of a Hybrid Liner for the Prevention of Contaminant Diffusion in Soils Contaminated with Total Petroleum Hydrocarbon
Authors: Park Jeongjun , Hong Gigwon
Published: October 2022

This study describes the test results to evaluate the impermeability efficiency, according to the total petroleum hydrocarbon (TPH) reaction time of a hybrid liner for preventing the TPH diffusion, and the numerical analysis results, according to the various TPH reaction times of the hybrid liner. The experimental results indicated that the hybrid liner performed effectively as an impermeable material under the condition of a 4 h reaction time between TPH and the hybrid liner. In other words, the permeability of the hybrid liner was lower than 7.64 × 10−7 cm/s when the reaction time of the TPH and the hybrid liner exceeded 4 h. This means that polynorbornene applied as a reactant becomes completely gelated four hours after it reacts with TPH, demonstrating its applicability as a liner. The numerical analysis results to evaluate the TPH diffusion, according to the hybrid liner-TPH reaction time indicated that the concentration decreased, compared to the initial concentration as the hybrid liner-TPH reaction time increased, regardless of the head-difference and the observation point for all concentration conditions. In addition, the reduction ratio of the concentration, compared to the initial concentration was 99% ~ 100%, when the reaction time of the hybrid liner-TPH was more than 4 h. It was found that the concentration diffusion of TPH reacting with the hybrid liner was decreased when the distance from the hybrid liner and the reaction time of the hybrid liner-TPH were increased. In other words, in the case of a high-TPH condition, the concentration reduction ratio is 12.5~17.8%, 16.9~29.7%, depending on the distance ratio (D/L = 0.06, 0.54, 0.94), respectively, when the reaction time of the hybrid liner-TPH is 0 h and 0.5 h, respectively. In the case of medium- and low-TPH conditions, the concentration reduction ratio, according to the distance ratio is 12.0% to 20.8% and 17.0% to 29.8%, respectively. This result means that a numerical analysis model can be used sufficiently to predict the TPH diffusion, according to the distance from the location where the hybrid liner is installed.
Telling You More Fluently: Effect of the Joint Presentation of Eco-Label Information on Consumers’ Purchase Intention
Authors: Wang Xingyuan , Du Yingying , Liu Yun , Wang Shuyang
Published: October 2022

An eco-label is an important tool for identifying green products in the marketplace. Most eco-labels, however, present a single icon that is simple and carries limited information, thus creating cognitive barriers for consumers. As a result, eco-labels might not always effectively promote green consumption. Based on dual coding theory and the spatial contiguity effect, this study investigated the effect of the “joint presentation of eco-label information” (JPEI), which adds (functional/emotional) descriptive text to eco-labels, on improving consumers’ cognitive fluency in eco-labels and subsequent purchase intention. We conducted three studies and found that, compared with the “single presentation of eco-label information” (SPEI), JPEI improved the cognitive fluency of consumers with low eco-label knowledge. Furthermore, spatially contiguous JPEI was more effective than spatially partitioned JPEI for consumers with low eco-label knowledge. In addition, we specifically explored the information types of JPEI that were effective for consumers with low eco-label knowledge. Low-construal consumers had higher cognitive fluency and higher purchase intentions under functional JPEI, and high-construal consumers had higher cognitive fluency and higher purchase intentions under emotional JPEI. The results of this study enrich eco-label research and can provide theoretical guidance for marketing practices in eco-labels.
Contribution of Home Gardens to Sustainable Development: Perspectives from A Supported Opinion Essay
Authors: Santos Mário , Moreira Helena , Cabral João Alexandre , Gabriel Ronaldo , Teixeira Andreia , Bastos Rita , Aires Alfredo
Published: October 2022

Home gardening has a long history that started when humans became sedentary, being traditionally considered an accessible source of food and medicinal plants to treat common illnesses. With trends towards urbanization and industrialization, particularly in the post-World War II period, the importance of home gardens as important spaces for growing food and medicinal plants reduced and they began to be increasingly seen as decorative and leisure spaces. However, the growing awareness of the negative impacts of agricultural intensification and urbanization for human health, food quality, ecosystem resilience, and biodiversity conservation motivated the emergence of new approaches concerning home gardens. Societies began to question the potential of nearby green infrastructures to human wellbeing, food provisioning, and the conservation of traditional varieties, as well as providers of important services, such as ecological corridors for wild species and carbon sinks. In this context. and to foster adaptive and resilient social–ecological systems, our supported viewpoint intends to be more than an exhaustive set of perceptions, but a reflection of ideas about the important contribution of home gardens to sustainable development. We envision these humble spaces strengthening social and ecological components, by providing a set of diversified and intermingled goods and services for an increasingly urban population.