bluuebunny/crossref_metadata_2025 huggingface dataset:
Marginalization of Bali traditional architecture principles
Authors: Pranajaya I Kadek , Suda I Ketut , Subrata I Wayan
Published: August 2020

The traditional Balinese architecture principles have been marginalized and are not following Bali Province Regulation No. 5 of 2005 concerning Building Architecture Requirements. In this study using qualitative analysis with a critical approach or critical/emancipatory knowledge with critical discourse analysis. By using the theory of structure, the theory of power relations of knowledge and the theory of deconstruction, the marginalization of traditional Balinese architecture principles in hotel buildings in Kuta Badung Regency is caused by factors of modernization, rational choice, technology, actor morality, identity, and weak enforcement of the rule of law. The process of marginalization of traditional Balinese architecture principles in hotel buildings in Kuta Badung regency through capital, knowledge-power relations, agency structural action, and political power. The implications of the marginalization of traditional Balinese architecture principles in hotel buildings in Kuta Badung Regency have implications for the development of tourism, professional ethics, city image, economy, and culture of the community as well as for the preservation of traditional Balinese architecture.
The Demise of Harwich Point College – New England University* Part A: The Day the Music Died
Authors: Sherman Herbert , Rowley Daniel James
Published: August 2020

This is a two part, field-based case which describes, from a faculty member’s perspective, some of the events which lead to the closing of the undergraduate programs at Harwich Point College – New England University. In Part A, a Professor receives an e-mail from the President of the University which was sent to the entire college community indicating that their undergraduate programs were to be transferred to another campus of the university; in Part B the professor has found some data on the college’s web site about the college and the university and wants to analyze the data in order to better understand the financial situation of both institutions. The case has a difficulty level appropriate for a junior level course. The case is designed to be taught in two class periods (may vary from fifty to eighty minutes each period depending upon instructional approach employed, see instructor’s note) and is expected to require between six to eight hours of outside preparation by students (again, depending upon instructor’s choice of class preparation method).
An analysis of the teaching performance of teachers of elementary schools in Kupang
Authors: Manu Lukas , Kallau Johanis N. , Taek Paulus , Kande Fredrik Abia
Published: August 2020

This research aims to reveal the differences between the performance of bachelor degree holder teachers and that of non-degree holder teachers of elementary schools in Kupang. It applies the survey method. The data were collected using a questionnaire. The validity of the questionnaire was measured using the Product Moment Correlation formula, and its reliability was measured using Alfa Cronbach formula. The data analysis used the non-parametric Mann-Whitney test with the help of the SPSS Program. The result of the study shows that there is a significant average difference between the teaching performance of bachelor degree holder teachers and that of non-degree holder teachers of elementary schools in Kupang. There is a significant average difference between the personality competence of bachelor degree holder teachers and that of non-degree holder teachers.  There is a significant average difference between the paedagogic competence of bachelor degree holder teachers and that of non-degree holder teachers. There is a significant average difference between the social competence of bachelor degree holder teachers and that of non-degree holder teachers. Therefore, it is suggested that non-degree holder teachers keep improving their academic qualification and work performance through varieties of self-development efforts.
USING STUDENT MENTAL STATE AND LEARNING SENSORY MODALITIES TO IMPROVE ADAPTIVITY IN E-LEARNING
Authors: Rodriguez Paola C. , Paternò Fabio , Jimenez Jovani
Published: August 2020

In this paper, we present an innovative solution to improve adaptivity in an e-learning system using Brain Computer Interface (BCI) measures (Attention/Meditation) in order to detect changes in students’ preferred perceptual modes for learning information (VARK model). Our solution is also able to report course units and learning resources that could be difficult for the students.
EL APRENDIZAJE ACTIVO SOPORTADepartamento de Ingeniería de Sistemas DO EN LA TECNOLOGÍA DE LA CONCIENCIA CONTEXTUAL
Authors: Gomez Jorge Eliecer , Hernández Velssy Liliana , Baena Navarro Ruben
Published: August 2020

La presente investigación tiene como propósito plantear una aproximación metodológica para el diseño de actividades de aprendizaje activo, que utiliza las técnicas de la conciencia contextual en entornos ubicuos de aprendizaje. Esta arquitectura utiliza la tecnología de RFID, con etiquetas pasivas y también se hace uso de los QRCODE, para establecer la interacción entre el estudiante y los objetos de aprendizaje que le rodean en el mundo real. Además de verificar los efectos que la misma tiene sobre el rendimiento académico de los estudiantes evaluados. Una vez diseñada e implementada la arquitectura se realizó una experiencia que permitió evaluar sus efectos sobre el proceso enseñanza aprendizaje en estudiantes universitarios. Se llega a la conclusión que la arquitectura facilita el aprendizaje de los estudiantes evaluados. Este trabajo muestra el impacto que estas nuevas tecnologías en computación pueden tener en la enseñanza universitaria, especialmente en programas de Ingeniería.
Desarrollo de habilidades informacionales (DHI) como competencia transversal en estudiantes de la pontificia universidad javeriana Cali: curso virtual de biblioteca una propuesta de formación
Authors: Vanegas Cuevas Nancy , Serna Collazos Andrea , Robles Maria Fernanda , Valencia Tatiana
Published: August 2020

En el presente artículo se presenta la descripción y resultados del proyecto: Desarrollo de Habilidades Informacionales (DHI) como competencia transversal en estudiantes de la Pontificia Universidad Javeriana Cali, que consistió en la implementación en tres asignaturas presenciales de pregrado de los módulos virtuales que hacen parte del curso virtual de Biblioteca (dispuesto en la plataforma educativa Blackboard) ofrecido en el marco de su programa de formación de usuarios. Este estudio piloto aplicado en el periodo 2013 – 2014, se inscribe en una metodología mixta con carácter descriptivo y su propósito fue el de identificar los cambios en el acceso y uso de la información a partir de la implementación de los módulos del curso virtual de biblioteca. Los resultados obtenidos demuestran el aumento en el acceso y uso de los recursos de Biblioteca y una curva de aprendizaje ascendente que evidenciaba el fortalecimiento de habilidades informacionales comunes entre los objetivos de los módulos del curso virtual y los propuestos en la asignatura presencial.
Um objeto de aprendizagem para o ensino de números complexos
Authors: Weyh Monzon Larissa , Rosecler Marta
Published: August 2020

Este artigo apresenta a concepção e a construção de um objeto de aprendizagem que trata de números complexos e funções destinado ao ensino médio da escola básica. Na concepção levou-se em consideração o importante papel que tem os sistemas de representação semiótica no processo de aprendizagem da matemática. A construção resultou em site web com coletânea de animações interativas que fazem uso de sistemas dinâmicos de representação algébrica e geométrica. O produto foi testado com uma turma de alunos do terceiro ano do ensino médio, e os resultados obtidos mostram que o apoio de ferramentas digitais facilitam o ensino-aprendizagem de matemática.
Centro de referência em tecnologia assistiva para a educação profissional (jun, 2014)
Authors: Bez Rosa , Oliviera Sandra , Weber Leo , Da Cruz Breno , Sardagna H V
Published: August 2020

Este artigo apresenta o Centro de Referência em Tecnologia Assistiva para a Educação Profissional da Fundação Escola Técnica Liberato Salzano Vieira da Cunha, que está sendo implementado na região do Vale do Rio dos Sinos, no Rio Grande do Sul, Brasil. O projeto tem como objetivo implementar um centro de referência em tecnologia assistiva para a educação profissional, ampliando a oferta de vagas na educação profissional através da criação de novos cursos e contemplando as políticas atuais de inclusão da pessoa com deficiência no mercado de trabalho. Apoiado em um Projeto Pedagógico Preliminar que justifica a construção de espaço físico que contemple a ampliação das vagas e as atividades de pesquisa do Centro de Referência em Tecnologia Assistiva. A respectiva proposta revela o desejo da Fundação Liberato em comprometer-se com mudanças significativas no lugar ocupado pelas pessoas com deficiência na sociedade e no mundo do trabalho, contribuindo para a constituição de espaços mais inclusivos.
ATENDERAH: A SERIOUS VIDEOGAME TO ENTERTAIN AND TEACH SKILLS IN ADULTS WITH ADHD
Authors: Mancera Laura Patricia , Baldiris Silvia Margarita , Fabregat Ramón
Published: August 2020

This paper describes a video game named aTenDerAH, which was created, designed and implemented for attending the needs of adults with Attention Deficit Hyperactivity Disorder (ADHD). The purpose of aTenDerAH is entertains while different cognitive and organizational areas are being taught. aTenDerAH is integrated into an e-learning platform as a recommended tool for students with ADHD which were previously diagnosed with a user modelling process. The videogame was developed using: Unity for the creation of the 3D game and also for the interactive content, Cinema 4D for the creation of the models and animations in 3D, and Photoshop for the creation of textures for the 3D models.
Determinación y Estandarización De Las Mejores Condiciones De Proceso De Lavado Cip (Cleaning In Place): En La Zona De Evaporación De La Planta Pulverizadora De Leche Colanta Planeta Rica
Authors: Perez Omar A. , Torres Ramiro , Montes Everaldo J. , Andrade Ricardo D. , Argel Vivian P. , Durango Alcides S. , Negrete Edwin
Published: August 2020

La industria lechera utiliza desde hace muchos años el CIP (cleaning in place) como método de limpieza. En la planta Pulverizadora Colanta Planeta Rica no existía un procedimiento de CIP que garantizara la eficiencia y condiciones constantes durante el proceso. Mediante modificaciones de infraestructura en los equipos, recomendaciones de los proveedores, revisión bibliográfica y ensayos realizados en la planta se logró determinar y estandarizar las condiciones para desarrollar el proceso CIP como; concentraciones y temperaturas de las soluciones de lavado, caudales y tiempos de proceso. Se logró que las soluciones de lavado recircularan a las concentraciones deseadas (soda caustica de 3 – 4% y ácido nítrico de 2 – 3%). Se consiguió mantener la temperatura de la soda en un rango de 70 a 80o C durante su recirculación en los efectos del evaporador. Se alcanzó el caudal máximo posible para realizar el CIP en el pasterizador el cual garantizara el arrastre total de partículas adheridas y se determinó el caudal más adecuado para el lavado del evaporador que garantizara una limpieza eficiente y evitara la inundación del equipo. Se logró la reducción del CIP de 6 a 4,5 horas representando una ganancia de $748 ́459.008 anuales, ya que el tiempo ahorrado es ahora invertido en la producción de leche en polvo, lo cual estuvo mayoritariamente influenciado por la reducción del tiempo de recirculación de soda en el pasterizador, el cual no se había bajado de 3 horas pese a la sospecha que pudiera influir negativamente en el equipo o en el proceso productivo.
Diseño e Implementación De Un Sistema Recomendador Para Apoyar La Selección De Programas Académicos En Educación Superior
Authors: Salas Daniel , Urango Carlos J. , Velásquez Darío , Martínez Julio
Published: August 2020

En la cotidianidad hay que enfrentarse a la toma de decisiones, unas más importantes que otras pero sin importar cuan trascendentes sean, representan un inconveniente para quien se tiene que decidir entre un grupo de opciones, pues muchas veces surge la confusión mental y las cuestiones sobre porque no se escogió tal opción en vez de otra. Cada día son más los individuos que recurren a las opiniones de terceros para tomar decisiones que le signifiquen un mayor provecho, ya que al desconocimiento sobre las opciones a elegir, tiende a dificultar la escogencia. Gracias a hechos como el expuesto la sociedad ha forzado la creación de entidades automáticas o semiautomáticas (de aquí en adelante Sistemas Recomendadores) que ejecuten el filtrado o selección de información relevante para los individuos interesados en un grupo de opciones, con lo cual se facilita la toma de decisiones; es por ello, que los Sistemas recomendadores se usan en una gran variedad de ámbitos como el comercio electrónico, la medicina y en un campo que siente los beneficios de herramientas como esta: la educación. Este proyecto se ubica en la línea de los sistemas recomendadores ya que está desarrollado para facilitar la toma de decisiones de los estudiantes que cursen décimo y undécimo de educación básica secundaria, teniendo en cuenta sus conocimientos en y sus preferencias. Este sistema soportado en la web, fue construido teniendo en cuenta el modelo tricapa (lógica, presentación y persistencia) usando el paradigma de orientación a objetos, el lenguaje de programación JAVA y su extensión hacia plataforma web, JSP. Adicionalmente el sistema cuenta con una serie de características que le permiten la administración de los datos usados en el proceso de recomendación así como también la elaboración de consultas y reportes.
DISTRIBUCIÓN DE INSTALACIONES: MÉTODOS DE SOLUCIÓN Y APLICACIONES RECIENTES
Authors: Alvarez Aldair , Moreno Alfredo , Noble Victor , Lopez Jorge
Published: August 2020

In this work is presented a state-of-art review of the Facility Layout Problem (FLP) and the its different solution methods, such as heuristic, metaheuristic and exact methods. Principally emphasizing in metaheuristic techniques such as Genetic Algorithm, Simulated Annealing, Particle Swarm Optimization, Ant Colony Optimization, Tabu Search and hybrid algorithm applied in the last years. Additionally some applications are shown of these methods in real and simulated scenarios.
REALIDAD AUMENTADA, VIDEOJUEGOS Y CAMBIO CLIMÁTICO
Authors: Fabregat Ramon
Published: August 2020

In this paper, Augmented Reality (AR) and Videogames are presented as two technologies suitable to be applied (independently and mixed) to Climate Change issues. The article is centered on teaching-learning, sensitization and awareness campaigns about Climate Change. On one hand, Augmented Reality and some examples of Climate-Change-related applications are presented. On the other hand, videogames are presented as useful tools for learning under the philosophy of Digital Game-Based Learning (DGBL). Some principles of DGBL are discussed and some examples of videogames applied to Climate Change issues are presented. Lastly Augmented Reality games are explored and an early classification is introduced. Finally, it is concluded that videogames and Augmented Reality are two current technologies that must be applied to processes related to education on climate change due to their features and nature.
ACCESIBILIDAD EN SITIOS WEB COLOMBIANOS
Authors: Duque Nestor , Flores Jimena , Castaño Natalia
Published: August 2020

Las cifras internacionales sobre personas con algún tipo de discapacidad, de lo cual Colombia no es ajena, representa un llamado para la comunidad encargada de fomentar, diseñar y construir sitios Web que permitan el acceso sin restricciones a personas con limitaciones de tipo técnico, físico, psicológico y social. Este trabajo, realiza la verificación del nivel de accesibilidad de sitios Web colombianos agrupados en ONGs, entes gubernamentales y medios de comunicación, aprovechando herramientas basadas en estándares y normas internacionales. Los resultados presentados no son muy alentadores y abren un espacio importante para la gestión institucional.
PROPUESTA CONCEPTUAL DE UN MODELO DE GESTIÓN DEL CONOCIMIENTO PARA UNA UNIVERSIDAD PÚBLICA: CASO FACULTAD DE INGENIERÍA UNIVERSIDAD DE CÓRDOBA.
Authors: Tordecilla Oswaldo
Published: August 2020

This work has been directed to devise a proposal for a Conceptual Model of Knowledge Management for a public university "Case School of Engineering University of Córdoba", supporting a diagnosis that identified the real situation of the faculty as a model knowledge management formally established . The model in context, should help to optimize the use and socialization of knowledge in the engineering faculty, in order to impact the mission processes of research, teaching, extension, Organizational Management and the local and national environment taking as reference the SECI model of knowledge creation .
TOWARDS AN OPEN LESSON PLAN DATA MODEL
Authors: Caeiro Manuel , Mendoza Miguel
Published: August 2020

This paper introduces some ideas towards the definition of a data model for open lesson plans. Lesson plans are a particular kind of aggregation resource that can include other types of educational resources, particularly learning objects. From this point of view, we consider on the data model available specifications in the learning domain, such as the Learning Object Metadata standard. This Open Lesson Plan proposal is performed in the context of a Web 2.X application, Edu-AREA, aimed at supporting teaching and teaching innovation. This application enables users to manage open lesson plans as living entities during their life-cycle: from their design, till their documentation with learning results and outcomes, passing through their use during the teaching/learning activity. In Edu- AREA users can share their lesson plans and they can be copied, adapted and “curated” by other users. Based on the principles of the Open Educational Resources movement, open lesson plans are proposed as an opportunity for sharing and collaboration among users.
GUÍA PARA CREAR UN OBJETO DE APRENDIZAJE
INCLUSIVO, BASADO EN MEDHIME
Authors: Moreira Maria
Published: August 2020

Through this document explain some inclusive strategies used in the Education Center apoyatura driving like the Virtual Learning Object "Early Warning", designed with MeDHiME and pedagogical structure was built on items to consider implementing Inclusive Education from Early Care (children 0-3 years) to the classes in regular schools.
Differentiation ability of rat‐mesenchymal stem cells from bone marrow and adipose tissue to neurons and glial cells
Authors: Noviantari Ariyani , Rinendyaputri Ratih , Ariyanto Ibnu
Published: August 2020

Mesenchymal stem cells (MSCs) are multipotent cells and can differentiate into neurons and glial cells. In vitro differentiation would be done by the addition of various factors. There remains no comparison for the differentiation of MSCs from rat bone marrow (rBMMSCs) and adipose tissue (rATMSCS) into neurons and glial cells with basic fibroblast growth factor (bFGF), epidermal growth factor (EGF), and brain‐derived neurotrophic factor (BDNF). The aims of this study were to investigate the effect of bFGF, EGF, and BDNF supplementation on the differentiation ability of rBMMSCs and rATMSCs into neurons and glial cells. MSCs were cultured with bFGF and EGF for 4 days and then BDNF was added until day 8. Characterization of MSCs before and after induction was carried out by observing the cell morphology and several cell markers. Flowcytometry analysis was performed for MSCs markers (CD90, CD29) and neurons and glial cell markers (A2B5, Beta‐III‐tubulin, PSAN‐CAM); while MAP‐2, a neuron marker, was analyzed by immunocytochemistry. Induction of both types of MSCs showed MAP‐2‐positive cells, decreased MSCs markers, and in rBMMSCs showed increased neuron markers. The number of neuron marker positive cells in rBMMSCS was higher than rATMSCs. This study showed that the addition of bFGF, EGF, and BDNF to the medium induced rBMMSCs into neurons and glial cells, but the conditions were not optimal for rATMSC as judged by the expression of neural markers (A2B5, Beta‐III‐tubulin, PSAN‐CAM, and MAP‐2).
Phylogenetic analysis of 23 accessions of Indonesian banana cultivars based on Internal Transcribed Spacer 2 (ITS2) region
Authors: Meitha Karlia , Fatmawati Intan , Dwivany Fenny Martha , Sutanto Agus , Pratama Sigit Nur , Nugrahapraja Husna , Wikantika Ketut
Published: August 2020

Pisang Kepok (Musa spp. [ABB ’Saba’ subgroup]) has several unique characteristics, such as tolerance to drought and Fusarium Foc (TR4) disease. Currently, the genetic diversity of Pisang Kepok in Indonesia is not well identified, although it is widely cultivated. Information on genetic diversity is essential for developing breeding strategies to achieve efficient cultivar improvement in the future. Aims of this research were to analyze the genetic variation of Pisang Kepok from some islands in Indonesia and to determine the genetic relationship between Pisang Kepok and other accessions banana cultivars based on ITS2 region, as a basis for future research in improving banana quality through molecular breeding. We have conducted the multiple sequence alignment and built the phylogenetic tree analysis using the Bayesian Inference Phylogeny method of one million generations (ngen = 1,000,000). The ITS2 region showed two clade ingroups: first clade consists of banana with B genome (balbisiana), while the second clade consists of banana with only A genome (acuminata). In general, all accessions of Pisang Kepok cultivars were clustered in the B genome of bananas cultivars. In addition, the ITS2 sequences and secondary structures among Pisang Kepok from various regions are identical, suggesting that there was no genetic variation in the ITS2 region of Pisang Kepok from multiple areas in Indonesia.
The potency of Pentagamavunone‐0 (PGV‐0) as chemopreventive agent for the formation and growth of breast cancer as revealed in 3D model
Authors: Wulandari Wulandari , Ikawati Muthi’ , Meiyanto Edy
Published: August 2020

Pentagamavunone‐0 (PGV‐0) or 2,5‐bis(4’‐hydroxy‐3‐methoxybenzylidine)‐cyclopentanone is a curcumin analogue that exhibits anticancer activity in breast cancer cells. However, most of previous reports are limited to the use of two‐dimensional (2D) cell culture. The use of three‐dimensional (3D) cell culture model in cancer research can represent the real condition of cancer growth in patients better than the 2D culture. The purpose of this study was to determine the anticancer activity of PGV‐0 on a 3D model of HCC 1954 breast cancer cells. HCC 1954 cells were grown in the 3D culture in the presence of PGV‐0, and the spheroid formation and growth of formed spheroids were observed using microscope at 24 and 96 h, respectively. The cytotoxic effects were measured by MTT assay. PGV‐0 inhibited the formation and growth of spheroids at the concentration as low as 60 µM. The cytotoxic effect of PGV‐0 appeared in a dose‐dependent manner with the IC50 value of 70.9 µM. The results of this study indicate that PGV‐0 has an anticancer activity on a 3D model of HCC 1954 breast cancer cell line. Therefore, the result supported the potency of PGV‐0 as cancer chemopreventive agent.
Development of English Communication Competence of Learners in Educational Institutes in Nakhon Ratchasima Province for Joining AEC
Authors: Dechsubha Thawascha
Published: August 2020

This research interpreted data from 4 research topics 1) Development of a New Method of English Instruction for Higher Secondary School Learners for Joining AEC, 2) Development of Basic English Communication for Occupational Progress of Non-Formal Education Learners in Nakhon Ratchasima Province, 3) Development of English Competence for Communication of higher Secondary School Learners in Nakhon Ratchasima Province for Joining AEC and 4)Development of English Skills of Tertiary Level Learners in Nakhon Ratchasima Province for Jobs and Occupational Opportunity.The purposes of this study were to (1) study ability of English speaking for communication of higher secondary school learners from Boonluawithayanusorn, and Baanluamwithayakhom higher secondary schools for joining AEC, (2) compare ability of English speaking for communication of higher secondary school learners from Boonluawithayanusorn and Baanluamwithayakhom higher secondary school for joining AEC for joining AEC, (3) study basic English speaking ability for occupational progress of non-formal education learners, (4) compare basic English speaking ability for occupational progress of non-formal education learners, (5) study the English speaking skill of the tertiary level learners in Nakhon Ratchasima in order to add up a chance of jobs and occupation and (6) compare the English speaking ability of the tertiary level learners in Nakhon Ratchasima in order to add up a chance of jobs and occupation.The population in this study consisted of 290 learners from higher secondary schools, from non-formal education department, and tertiary level who took English course during the second semester of the academic year 2015. Samples consisted of 140 learners from higher secondary schools, non-formal education department, and tertiary level who took English course during the second semester of the academic year 2015 through the purposive sampling random. Eight weeks were spent on this research. The instruments were (1) the questionnaire related to students’ problems about the English instruction, (2) classroom observation, (3) semi-structured interview, and (4) English speaking ability test (pre-test and post-test. The scores of English speaking ability were analyzed and interpreted statistically in terms of mean (x?), standard deviation (S.D.), and t-test (pretest and posttest) with the criterion of 60%.
Effect of Innovative Finance on Kenya’s Public Debt
Authors: Meme Loran M. , Fatoki Olanrewaju Isola
Published: August 2020

This study was to determine the effect of innovative finance on Kenya’s public debt. Specifically, it aimed to establishing the effect of foreign remittance, financial transaction tax and guaranteed loan financing on public debt level in Kenya. A descriptive research design was adopted and population of interest for the study was Kenya. Secondary data for a period of 5 years from 2014 to 2018 was utilized while the Vector auto regression model was estimated to establish the relationship between the variables. The results indicated that there is a positive and significant relationship between foreign remittance and public debt in Kenya while a negative and significant relationship was established between financial transactions tax, no significant relationship was established guaranteed loans and public debt in Kenya. The study concludes that foreign remittance has a positive and significant effect on public debt level in Kenya while financial transactions tax has a negative and significant effect. It therefore recommends that the government through relevant institutions should strengthen policies on various innovative taxes including financial transactions tax. This will ensure that more revenue is obtained through taxes; this can be used to repay existing loan as well as financing development.
DETERMINATION OF THE TOTAL PHENOLICS AND ANTIOXIDANT ACTIVITY IN THE RIND EXTRACTS OF GARCINIA MANGOSTANA L., GARCINIA COWA ROXB., AND GARCINIA ATROVIRIDIS GRIFF. EX T. ANDERS.
Authors: ANDAYANI REGINA , ARMIN FITHRIANI , MARDHIYAH AINUL
Published: August 2020

Objectives: Garcinia atroviridis Griff. ex T. Anders., Garcinia mangostana L., and Garcinia cowa Roxb. are plants of the genus Garcinia that has been widely used by the community as a food flavoring, spices, and also as a herbal medicinal ingredient. This research aimed to evaluate the total phenolics and antioxidant activity from three species of Garcinia (G. atroviridis Griff. ex T. Anders., G. mangostana L., and G. cowa Roxb.)
Methods: The total phenolic content (TPC) of the extracts was estimated as Gallic Acid Equivalent by the Folin-Ciocalteu method. Antioxidant activity was assessed using Ferric Reducing Antioxidant Power assay.
Results: The TPC of G. mangostana L. rind extract is higher (31.83±3.70%), than G. cowa Roxb.(4.35±0.17%) and G. atroviridis Griff. ex T. Anders. (2.47±0.42%). Based on the antioxidant activity, G. mangostana L. rind has a higher total antioxidant activity (24.68 μmol Fe(II)/g) than G. cowa Roxb. (18.88±0.12 μM Fe (II)/g and G. atroviridis Griff. ex T. Anders.(17.61±0.05 μM Fe(II)/g).
Conclusion: The results showed that G. mangostana L rind extract contains a higher level of TPC and antioxidant activity among the other rinds. The results obtained indicate that the three samples have the potential to be a source of natural antioxidants. Further studies must be carried out to isolate compounds that have antioxidant activity.
COMPARISON OF EFFECTIVENESS OF STANDARD TRIPLE THERAPY VERSUS BISMUTH-BASED THERAPY FOR THE MANAGEMENT OF PEPTIC ULCER DISEASE DUE TO HELICOBACTER PYLORI
Authors: BAIG MIRZA MISBA ALI , PARVEEN UZMA , FAROOQ RUQAIAH , TABASSUM MAIMUNA , NAAZ FATIMA , IBRAHIM HASSAN SYED
Published: August 2020

Objective: Helicobacter pylori is the primary agent causing peptic ulcer, therefore imposing a significant impact on health elated quality of life, consequently affecting nearly 50% of global population. The objective of this study is to determine and assess the effectiveness of triple therapy versus bismuth containing quadruple therapy for eradication of peptic ulcer disease due to H. pylori.

Methods: A prospective randomized observational study was conducted at Princess Esra Hospital, Department of Gastroenterology for a period of 6 months. A total of 100 patients were randomly allocated in tow groups. The data were assessed using various parameters. H. pylori eradication was validated using rapid urease test done at the start treatment 4 weeks after the completion.

Results: A total of 100 patients were recruited in the study. In triple therapy group medication adherence rate was found to be 82% in triple and 92% in quadruple therapy. The eradication rate was assessed using Chi-square test it was 82% and 97% in triple and quadruple therapy group, respectively. Hence, the difference was found to be statistically significant value <0.005. In addition, increased recurrence rate has been observed in triple therapy (17%) in contrast with quadruple therapy (2%).

Conclusion: Addition of bismuth to significant triple therapy improves cure rates with minimal side effects. Interestingly, we observed that when bismuth was added, it produced a significant higher eradication rate (97%) when compared with standard triple therapy (82%). According to our study, bismuth is highly effective treatment of peptic ulcer disease.
MODULATORY ROLE OF SELENIUM AND VITAMIN E AGAINST OXIDATIVE STRESS INDUCED HEPATOTOXICITY AND NEPHROTOXICITY IN RATS EXPOSED SUB-CHRONICALLY TO HEXAVALENT CHROMIUM
Authors: CHOUDHURI SOMA , SAHA JAHNABI , DAS SANDEEP , CHOUDHURI DIPAYAN
Published: August 2020

Objective: The present study assessed the hepatotoxicity and nephrotoxicity associated with oxidative stress induced by chronic exposure to a very low environmentally relevant dose of hexavalent chromium along with the ameliorative potential of selenium and Vitamin E in male rats.

Methods: Twenty-four male albino rats were divided into four groups. Animals of control group received only distilled water. The treated group received solution of potassium dichromate (K2Cr2O7) at a dose of 1 mg/kg b.w./day. The third group received sodium selenate (0.25 mg/kg bw) plus Vitamin E (100 mg/kg bw). The supplemented group received sodium selenate plus Vitamin E along with K2Cr2O7 solution. The animals were treated for 90 consecutive days.

Results: There was a significant decrease in body weight gain and an increase in liver and kidney weight along with an increase in serum glucose, cholesterol, urea, and creatinine; a decrease in protein and albumin levels in the rats treated with K2Cr2O7. The activities of serum enzymes, serum glutamate oxaloacetate transaminase, serum glutamate pyruvate transaminase, acid phosphatase, and alkaline phosphatase, were also increased in treated animals. The activities of enzymes catalase, superoxide dismutase, GPx and the levels of GSH reduced significantly and level of malondialdehyde increased in K2Cr2O7 treated rats. Liver and kidney tissues exhibited features of toxicity in chromium treated animals. All the effects were reversed in supplemented group.

Conclusion: Chronic exposure to K2Cr2O7 at a very low environmentally relevant dose caused hepatotoxicity and nephrotoxicity induced by oxidative stress in male albino rats; the effects were ameliorated by supplementation with selenium and Vitamin E in combination.
KNOWLEDGE, ATTITUDE, AND PRACTICES OF SELF-MEDICATION AMONG THE STUDENTS OF PRIVATE UNIVERSITY
Authors: SUTHAR JALPA , SHRINA P PATEL , RIDDHI N SOLANKI
Published: August 2020

Objectives: Self-medication is becoming very common in our routine life which is an unhealthy and risky practice in a few instances. The present study was carried out to determine the knowledge, attitude, and practice of self-medication among students of Charotar University of Science and Technology (CHARUSAT).

Methods: A pre-validated questionnaire was prepared and distributed among the students. Data was collected and analyzed using Microsoft Excel and the results expressed as counts and percentages.

Results: A total of 431 students participated voluntarily in the study. The most common reason for taking self-medication was found in 70% of total students. We found that the source of information of the drugs used for self-medication was “previous prescription (57%)” and source of drugs was “medical store (66%).” Only (46%) students accepted the fact that they always visited a qualified practitioner whenever they felt ill. Most of the students took self-medication for headache (82%) followed by cough, cold, and sore throat (62%) and fever (57%). Of total 431 students, most of the students took analgesics (78%) as self-medication followed by lozenges (50%).

Conclusion: Self-medication was common in nearly 70% of university students. They provided the reason that “no needs to visit the doctor for minor illness.” Cough and cold preparations were taken by 82% population as self-medication.
CASE STUDY ON IFOSMADIDE-INDUCED CYSTITIS
Authors: PASULA SRINIVAS , HUMAIRA HUSSAINI SYEDA ZAINEB , GV NAGARAJU
Published: August 2020

Adverse drug response elaborates, is response to the drug which is caused to an organ or tissue damage for normal dose in the patients for the prophylaxis, 22 years male patient was hospitalized with complaints of relapsed Hodgkin’s lymphoma (HL) using post-Adriamycin, Bleomycin, Binblastine, and Dacarbazine regimen. The patient had treated HL with ICE regimen, after 24 hours of treatment with prescribed the ICE regimen, The patient was observed with following symptoms like vomiting, painful burning micturition and laboratory investigations reported. Abnormal then we suggested Mesna 3 days for prophylactic course then symptoms were not found and patient was discharged. We conducted Adverse drug reaction (ADR) assessment was resulted as probable type and we can probably prevent this type of ADR.
FORMULATION DEVELOPMENT AND CHARACTERIZATION OF EFFERVESCENT TABLETS ALONG WITH LEVOCETIRIZINE DIHYDROCHLORIDE
Authors: AKHTAR SEMIMUL , HUSSAIN SOEB , MANDAL SUDIP KUMAR
Published: August 2020

Objective: Levocetirizine dihydrochloride is also known as “Xyzol.” Levocetirizine dihydrochloride is a second-generation piperazine derivative, potent H1 selective agent. Levocetirizine dihydrochloride is the active R (-) enantiomer of cetirizine dihydrochloride. In the case of an allergic or histaminic reaction, the medication must respond rapidly. Many older patients, infants, and dysphagia patients have trouble swallowing traditional tablets or capsules. Hence, a need exists for a relatively fast-acting effervescent tablet form.

Methods: The tablets were prepared by direct compression method using citric acid and sodium bicarbonate as effervescent agents. Then, they were tested for parameters of pre- and post-compression. Tablets were evaluated for studies of general appearance, uniformity of substance, hardness, friability, and in vitro dissolution.

Results: More than 90% of the drug was released from almost all the formulations within 1 min. More formulations underwent rapid 90-day stability trials.

Conclusion: No major changes in the taste, disintegration, and dissolution profiles were found in tablets.
THE PHYTOCHEMICAL SCREENING HEXANE AND METHANOL EXTRACT OF SINYO NAKAL (DURANTA REPENS)
Authors: SUGITA PURWANTININGSIH , AMILIA RIZKI , ARIFIN BUDI , RAHAYU DYAH UTAMI CAHYANING , DIANHAR HANHAN
Published: August 2020

Objective: Phytochemicals are naturally present in every part of plants range from leaves, stem bark, and fruits to roots. The use of plant-based medicine is popular among individuals and communities in developing countries. This study evaluated that the phytochemical profile of Duranta repens fruits was collected from Jombang, East Java, Indonesia.

Methods: Air-dried D. repens fruits were macerated by n-hexane and methanol, a separate flask. n-Hexane extract, then underwent saponification to remove fat. Then, the unsaponifiable of n-hexane and methanol extract was tested through phytochemical screening, respectively.

Results: The methanol extract showed the presence of alkaloids, flavonoids, tannins, and steroids, but the unsaponifiable fraction only contained steroids. The unsaponifiable fraction was found to be a mixture of hydrocarbons ranging from C13-C20, fatty acids (palmitic and linoleic acid), squalene, and Vitamin E.

Conclusion: The phytochemical screening of the plant plays an important role for pharmaceutical studies especially discovering new potential drugs for the treatment of various diseases.
CURRENT THERAPEUTIC OPTIONS FOR CORONAVIRUS DISEASE-2019 – A PHARMACOLOGICAL REVIEW
Authors: MB SASMI , JOSE MARIA , KUTTICHIRA PRAVEENLAL
Published: August 2020

Objectives: Coronavirus pandemic is currently a global public health emergency. With expanding knowledge of the virus and the disease, new therapeutic targets are emerging widely. There is limited evidence about the use of different treatment options in coronavirus disease-2019 (COVID-19). This review aims to summarize the available evidence regarding therapeutic options in treating coronavirus infection.

Methods: We searched PubMed, Google Scholar, and Cochrane library using pre-specified Medical Subject Headings terms about the role of therapeutic options in COVID-19 patients.

Results: The majority of the published evidence is either case reports or small observational studies. Antimalarial like hydroxychloroquine reported equivocal results with five studies got positive results and five without any added benefit compared with standard of care. Lopinavir/ ritonavir monotherapy does not show any significant role except in combination with other antiviral drugs but encouraging results are emerging with remdesivir. Studies with favipiravir are inconclusive with some exhibit benefit and others not. Limited case series have shown that tocilizumab and convalescent plasma to be useful as adjuvant therapy in critically ill patients.

Conclusion: There is currently no strong evidence for the efficacy of different therapeutic agents in the treatment of COVID-19. More data from ongoing and future trials will add more insight into the role of various drugs.
HISTOPATHOLOGICAL STUDY OF THE PROTECTIVE EFFECT OF SPIRULINA PLATENSIS ON FETAL LIVER OF MICE WITH ACUTE FATTY LIVER OF PREGNANCY
Authors: KARGARZADEH MARYAM , NASRABADI MITRA HEIDARI , DASTPAK AREZO , KARGARZADEH HANIEH
Published: August 2020

Objective: The protective effect of Spirulina platensis on the fetal liver of mice with acute fatty liver of pregnancy was investigated.

Methods: Small female mice were divided into four groups: A control group with a standard diet, a high-fat diet to induce liver steatosis, a high-fat diet plus Spirulina, and a high-fat diet plus Simvastatin given through gavage to protect the liver against steatosis. After 2 months, the female mice became pregnant by polygamy method at the same time they were treated by different diets. On day 17, the fetuses were removed by C-section, and histological studies were carried out on their livers.

Results: The results showed a significant decrease in liver steatosis in the group treated by Spirulina compared with the other groups (p<0.05). The fatty liver of pregnancy could lead to liver failure and death in both mother and fetus, and medications like Simvastatin that is used for the treatment of fatty liver are harmful to the fetus. However, Spirulina shows a positive effect on the treatment of both fetus and mother.

Conclusions: The results of this study show that Spirulina is an effective medical supplement in the treatment of fatty liver of pregnancy.
Estrategias de diversificación y concentración empleadas por las sociedades anónimas en Chile
Authors: Medina Giacomozzi Alex , Constanzo Hidalgo Alexis , Sandoval Soto Rodrigo
Published: August 2020

Uno de los temas de investigación más interesantes en estrategia es el estudio de cómo las empresas enfrentan su crecimiento de mercado corporativo, ya sea mediante una estrategia de diversificación o de concentración. Sobre este tema hay una amplia variedad de publicaciones, en las cuales algunos autores establecen la preeminencia de la diversificación por sobre la concentración, aunque existen otros que llegan a la conclusión inversa. Esta diversidad de resultados, que se ha obtenido en el estudio de las estrategias de mercado, propicia que se siga investigando el tema; por ello, el objetivo central de este artículo es exponer los resultados obtenidos en la investigación de las estrategias de crecimiento de mercado corporativo —diversificada o concentrada— más utilizadas por las sociedades anónimas chilenas en la actualidad. Los principales resultados obtenidos, a partir de una muestra aleatoria de empresas, es que la estrategia más utilizada por las sociedades anónimas en Chile es la estrategia de concentración con negocios especializados por encima de la diversificación.
Aerolíneas de bajo costo en México Competencia modal, intermodal e intramodal
Authors: Cruz Rodríguez Ignacio Javier
Published: August 2020

Mediante diversos métodos se estimó el impacto que tuvo la entrada de aerolíneas de bajo costo (ABC) al mercado de transporte de pasajeros en México; para ello se distingue una tipología de la competencia en modal, intramodal e intermodal. Se encontró que para todos los tipos de competencia el ingreso de las ABC resultó provechoso para los usuarios de este tipo de servicios.
Los enunciados constatativos y realizativos en el discurso administrativo para la construcción de organizaciones lucrativas
Authors: Galicia Osuna David
Published: August 2020

El objetivo de este ensayo es mostrar, desde la semiótica y la pragmática, dos tipos de enunciados que componen al discurso administrativo: enunciados constatativos y no constatativos; estos últimos nos permiten hablar de la intencionalidad en la construcción de organizaciones lucrativas, lo que nos hace responsables de ellas, pero también de su posible renovación con un sentido más humano, como ya señala Omar Aktouf. Se propone que en el discurso administrativo hay dos tipos de enunciados que conforman al discurso administrativo: enunciados constatativos (o verificativos), y principalmente enunciados realizativos (Austin, 1971). Los primeros buscan la verdad; los segundos, desde una perspectiva pragmática (Rorty, 1993), la eficacia (Searle, 1999) para construir una organización.
Análisis sobre la reputación de marca, las emociones y la confianza como formadoras de la satisfacción del turista
Authors: Matos Cámara Rafael Fabricio , San Martín Gutiérrez Sonia
Published: August 2020

Este trabajo propone un modelo causal de múltiples relaciones entre la reputación de marca de un destino turístico y los efectos de las emociones como estímulos de respuestas del turista durante su visita; asimismo, se desea saber cómo estas variables establecen su confianza para conseguir su satisfacción. El estudio se contrastó empíricamente para el caso del destino turístico ecoarqueológico mundo maya-México; por ello, se desarrolló un marco teórico multidisciplinar con aportaciones de la teoría de señales, la teoría de emociones en marketing y el marketing de relaciones; este modelo desarrollado y propuesto se centró en dos enfoques: el cognitivo-afectivo de la satisfacción y el de factores afectivos procedente de la psicología ambiental. Los resultados que se obtuvieron corroboran la mayoría de nuestras hipótesis y arrojan resultados importantes en el ámbito académico y profesional. Así, la reputación del destino, las emociones y la confianza del consumidor resultan determinantes sobre la satisfacción del turista durante su visita a un destino turístico.
Editorial 57-2
Authors: García Narváez José Alberto , López Herrera Francisco
Published: August 2020

La política monetaria es de natural importancia para la marcha de las empresas pues los efectos de esa política  afectan a muchas decisiones de inversión que se tienen que tomar, así como a las operaciones y los costos de cobertura de los riegos financieros y operativos que enfrentan esos organismos. Como se plantea en el artículo que nos ofrecen Santiago Capraro Rodríguez e Ignacio Perrotini Hernández, titulado Intervenciones cambiarias esterilizadas, teoría y evidencia: el caso de México, los bancos centrales que han optado por el establecimiento de objetivos de inflación niegan que su intervención en los mercados cambiarios sea un instrumento que contribuya al logro de los objetivos que persiguen mediante la política monetaria. El argumento que esgrimen es que dicha intervención no tiene eficacia cuando se sigue un régimen de libre flotación, pues es el propio mercado el que fija la paridad de equilibrio; sin embargo, en la práctica se observa que llevan a cabo intervenciones en el mercado de cambios de manera regular. Capraro y Perrotini investigan en su trabajo el papel de las intervenciones cambiarias esterilizadas en el marco de la política monetaria del Banco de México durante el periodo de 1996 a 2010. De esta forma, el análisis que llevan a cabo dichos investigadores revela que las intervenciones cambiarias esterilizadas efectuadas por la autoridad monetaria mexicana sí han sido efectivas, y que el tipo de cambio ha desempeñado un papel esencial en la estabilización de la inflación en México. Es conveniente destacar que estos resultados de Santiago Capraro e Ignacio Perrotini van de la mano con el planteamiento de Ostry et al. (2012), en el sentido de que las intervenciones esterilizadas en el mercado cambiario pueden facilitar el logro de inflación baja, junto con estabilidad macroeconómica y un tipo de cambio que en términos reales se mantenga en torno al nivel consistente con los fundamentales económicos, lo que resulta muy significativo, pues implica que incluso en el Fondo Monetario Internacional se ha abierto la discusión sobre la pertinencia de adoptar como segundo instrumento de política monetaria dicho tipo de intervenciones.
Intervenciones cambiarias esterilizadas, teoría y evidencia:el caso de México
Authors: Capraro Rodríguez Santiago , Perrotini Hernández Ignacio
Published: August 2020

Los bancos centrales que aplican un marco de política monetaria de metas u objetivos de inflación niegan que las intervenciones en los mercados cambiarios sean un instrumento adicional de su praxis política para alcanzar los objetivos de política monetaria, so pretexto de que en un régimen de tipo de cambio flexible esas intervenciones no son efectivas. Este trabajo analiza, con base en evidencia empírica, el papel de las intervenciones cambiarias esterilizadas en el marco de la política monetaria del Banco de México. Nuestros resultados revelan que las intervenciones cambiarias esterilizadas sí han sido efectivas y que el tipo de cambio ha desempeñado un papel esencial en la estabilización de la inflación en México.