bluuebunny/crossref_metadata_2025 huggingface dataset:
FOREIGN EXPERIENCE OF THE FUNCTIONING OF PENITENTIARY SYSTEMS: PROSPECTS FOR IMPROVING NATIONAL LEGISLATION
Authors:   erritorially Separate Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine, Malinkovska О.V. , Tymoshchuk О.І. ,   Territorially Separate Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine, Brunevych V. M. ,   Territorially Separate Branch “Khmelnytskyi Branch of the Academy of the State Penitentiary Service”,  Khmelnytskyi, Ukraine
Published: April 2023

The article analyzes advanced practices of the functioning of penitentiary systems in foreign countries. Attention was focused on such aspects as: the expediency of using deprivation of liberty as the main form of punishment, the types of institutions for the execution of punishment, the functioning of state and private institutions of deprivation of liberty and the expediency of introducing a similar practice in Ukraine, professional training of personnel of institutions of deprivation of liberty. In particular, it was established that such type of punishment as deprivation of liberty is not an effective measure, as there is a probability of repeated crimes. This led to the analysis of the experience of applying criminal punishments associated with deprivation of liberty in those foreign countries where recidivism after release has a fairly low share of all crime. Due to repeated statements about the creation of private prisons in Ukraine, special attention was paid to this issue. Countries where the practice of private prisons has already been tested (USA, Great Britain, Australia) were taken as an example, and issues that should be paid special attention to when introducing this institution in our country were summarized. Taking into account the fact that the personnel of the penal institutions are constantly in contact with the convicted person due to the performance of their official duties, the issue of his professional training is highlighted as important. In this aspect, the preparation for the humanization of personnel education and the technology of combining theory and practice with the introduction of progressive experience of penitentiary activity deserve further analysis and implementation. It is clear that it is impossible to fully borrow foreign experience in the application of deprivation of liberty and serving a sentence, but the isolated issues must be taken into account when implementing progressive practices into national legislation. Key words: penitentiary system; criminal law; execution of punishments; convicts; probation; institutions of execution of punishments; national legislation; implementation.
SCIENTIFIC VIEWS OF M. P. CHUBYNSKYI (1871-1943) ON THE GUIDELINES OF THE SCIENCE OF CRIMINAL LAW AND THE MOTIVE OF A CRIMINAL OFFENSE
Authors:   Academy of the State Penitentiary Service, Chernihiv, Ukraine, Puzyrevskyi M.V.
Published: April 2023

The scientific views of M. P. Chubynskyi regarding criminal law science and the motive of criminal offense were studied. It was determined that the research conducted by the scientist on the science of criminal law, the motives of criminal offenses and their significance for criminal law and criminal legislation definitely laid a solid foundation for conducting further scientific research on the given issue, brought the scientist to the advanced level of criminal law science, and the reasoned instructions given by him and proposals contributed to the future enrichment of the theory of criminal and legal science, ensured the improvement of domestic and foreign criminal legislation. It was found out that the study of the history of domestic criminal law science, in particular, the views of its best representatives, which M. P. Chubynskyi definitely was, served as a basis for improving legal thinking, criminal law and criminal legislation, and the practice of its application in future. The author’s position is given regarding the definition of the science of criminal law as a branch of legal science, a complex structured system of teachings, ideas, concepts, views and theories about the problematic issues of the development of the conceptual apparatus of criminal law, the law on criminal responsibility, its main criminal law institutions, categories and norms, criminal law policy of the state, criminal law aspects of crime prevention, practice of law enforcement of criminal legislation of Ukraine and prospects for its development in future, genesis of national domestic and foreign criminal law and legislation. In addition, the author’s position was given regarding the definition of the motive of a criminal offense as an internal volitional urge by the subject of a criminal offense to commit a criminally illegal act or omission provided for by the law on criminal liability. Key words: scientific views, M. P. Chubynskyi, criminal law, science of criminal law, criminal offense, motive of criminal offense.
Los contenidos, los actores y los intereses detrás de las noticias falsas. Un análisis de los bulos verificados en España y Colombia
Authors: Hernández Rodríguez Juan Camilo , Londoño Pardo Óscar Iván
Published: April 2023

Esta investigación analiza el contenido de 416 noticias falsas identificadas durante el primer semestre de 2021 por Maldita.es y Newtral.es, de España, y Colombiacheck y La Silla Vacía, de Colombia. Los resultados muestran que la mayoría de los autores de las noticias falsas son anónimos y que estas perjudican especialmente a los gobiernos de turno y otros funcionarios públicos. Los intereses de los actores promotores son político-gubernamentales, político-institucionales y reputacionales. El estudio también da cuenta de las temáticas, formatos y canales de distribución de las noticias falsas.
Clinical Profiles of Major Depressive Disorder Based on Age Groups: A Cross-Sectional Study, Vietnam.
Authors: Ho Phi Nguyen Yen , Truong Tho Quoc , Nguyen Tram Nhu Thanh , Nguyen Tram Ly Bich , Bui Manh Xuan , Tran Ngoc Anh , Pham Chau Thi Minh , Nguyen Phu Thi , Ai Phan Ngoc , Tran Nghia Trung , Ngo Linh Tich
Published: April 2023

Depression is a common mental disorder; however, no study has investigated adolescent and late-life depression in Vietnam, and little has been done to compare the clinical characteristics among age groups of patients with this condition in the literature. Therefore, the study aims to examine the differences in symptom presentation among adolescents, adults, and the elderly with major depressive disorder (MDD). A total of 238 patients diagnosed with MDD according to the DSM-5, including 43 aged 10 to 17 years old, 74 aged 18 to 59 years old, and 121 aged 60 and older, were recruited in a cross-sectional study from March to August 2022 at three psychiatric clinics in Ho Chi Minh City. The eligible participant completed an epidemiological questionnaire. All participants exhibited depressed mood, and 58.8% admitted to having suicidal ideation, with an alarming rate among adolescents (72.1%). Adolescents were less likely to experience the symptoms of interest decrease, appetite problems, insomnia, fatigue, and anxious distress than these other groups (p < 0.05). The pattern of symptom profiles in depressed adults largely remained the same in the older patients, except for psychomotor retardation and concentration problems, in which the latter were less likely to exhibit these symptoms compared to the first one (p<0.001). Adolescents appear to experience fewer depressive symptoms than adults and the elderly, while the two later groups show similar clinical presentations. Therefore, the differences in symptoms across age groups necessitate an individual approach and management by clinicians.
Survey on change temperature of skin surface when using auricular acupuncture at the Jaw point in each side of the ear in healthy people: A cross-over study
Authors: Huynh Quoc Kha Vo , Bui Minh Man Pham , Trinh Dieu Thuong Thi
Published: April 2023

Auricular acupuncture (AA) is a method for diagnosing and treating physical and psychosomatic dysfunctions by stimulating a specific point in the ear. Some studies prove that the acupoints on the pinna have a corresponding relationship to areas of the body. According to several studies, acupoints on the body may influence the temperature of the corresponding region. In our study, we surveyed the change in temperature of the skin surface at the mandibular area when using AA at the Jaw point on each side of the ear in healthy people. A cross-over study with 35 healthy volunteers was conducted in the Acupuncture Experimental Research Lab, Faculty of Traditional Medicine, University of Medicine and Pharmacy at Ho Chi Minh City from November 2021 to May 2022. Temperatures of the mandibular area before and after using auricular acupuncture were recorded. After using AA at the Jaw point on the left, the temperature of the left mandibular area was increased statistically from that before (from 34.34 ± 0.69 to 34.76 ± 0.72). After using AA at the Jaw point on the right, the temperature of the right mandibular area was increased statistically from that before (from 34.50 ± 0.86 to 34.31 ± 0.68). No side effects were observed during the study. When using AA at the Jaw point on the ear, the temperature of the mandibular area on the side of using auricular acupuncture increased statistically, showing the relationship of the Jaw point on the ear with the mandibular area.
Investigation on the Behavior of Bridge Piers Considering Rocking Isolation Constructed on Non-plastic Silts and Sands Using 1g Shaking Table Tests
Authors: Esmatkhah Irani Arash , Hajialilue Bonab Masoud , Behrooz Sarand Fariba , Katebi Hooshang
Published: April 2023

Occurred damages on the bridge piers during earthquakes lead to significant financial losses worldwide every year and can cause social problems by disrupting traffic flow and transportation services. Rocking isolation of foundations is one of the damage reduction approaches to avoid structural damage on piers by transferring plastic hinges from piers to underlying soil media. The behavior of rocking foundations on non-plastic silts has not been investigated well until now in the literature. In this research, the characteristic seismic behavior of a bridge pier considering rocking isolation is evaluated using small-scale physical modeling tests. To this aim, eight shaking table tests (with sinusoidal excitations) are conducted where both sandy and silty materials are employed as the soil media. In addition to the effects of the underlying soil, the effects of the critical contact area ratio of the foundation and frequency of input motions are evaluated. Achieved results indicate that the considered bridge pier shows the same behavior trend for underlying silty soil and sandy one. However, because of the frequency-dependent behavior of non-plastic silty soil, the pier attracts lower accelerations and higher moments. Therefore, the achieved results show that the proposed design approaches of rocking foundations that are mostly extracted based on experimental studies on sands (or rarely on clay) can lead to non-conservative designs in silty soils.
Latin Amerika Entegrasyon Topluluğu Üye Ülkelerinin Lojistik Performans Endeksine Uluslararası Ticaretin Etkisi
Authors: BOZKURT Tuba , KARAKÖY Çağatay
Published: April 2023

Bilim ve teknolojinin hızla ilerlemesiyle artan küresel ticaret beraberinde lojistiğin önemini de artırmıştır. Uluslararası alanda yaşanan yoğun rekabet ortamında işletmelerin rekabet üstünlüğü yakalayabilmesinde lojistik önemli bir unsur haline gelmiştir. Lojistik firmaların taşımaya konu olan hammadde ve\veya ürünlerin başlangıç noktasından teslim noktasına kadar geçen süreçte düşük maliyet, hız ve yüksek hizmet kalitesi ile müşteri ihtiyaçlarına cevap verebilmesi gerekmektedir. Bu gelişimlerin değerlendirilmesi noktasında Dünya Bankası her iki yılda bir ülkelerin lojistik performanslarının altı alt kriter üzerinden puanlayarak sıraladığı bir endeks yayınlamaktadır. Lojistik Performans endeksine (LPI) göre ülkeler, lojistik faaliyetler açısından bulundukları noktada kendilerini analiz edebilme ve eksikliklerini görerek iyileştirme çalışmaları yapabilmektedirler. Bu çalışma, Latin Amerika Entegrasyon Topluluğu ülkelerinin (Şili, Uruguay, Brezilya, Peru, Venezuela, Paraguay, Ekvador, Bolivya, Meksika, Arjantin, Kolombiya) Lojistik Performans Endeksine; ithalat, ihracat, yabancı sermaye yatırımları (FDI), çalışma özgürlüğü, yatırım özgürlüğü gibi değişkenlerin etkilerinin ölçülmesi amacıyla yapılmıştır. Çalışma için ulaşılan veriler Eviews paket programında analiz edilmiştir. Analiz sonucunda, Latin Amerika Entegrasyon topluluğu ülkelerinin lojistik performans endekslerine ihracatın pozitif yönde katkılarının olduğu ithalatın ise negatif etkili çıkması çalışmadan beklenen sonuçları bizlere yansıtmıştır. Yabancı sermaye yatırımlarının ülkelere çekilmesi yönünde lojistik performansların etkili olması ve özgürlük endeksleri açısından yatırım özgürlüğü ve çalışma özgürlüğünün destekler nitelikte sonuçlar vermesi çalışmanın literatüre katkıları arasında yer almaktadır.
Türk Atasözlerinde Yer Alan Pedagojik Anlamlar ve Çağdaş Yansımaları
Authors: YILDIRIM Bilal , YILDIRIM Nur Hilal
Published: April 2023

Bu araştırmanın amacı, Türk atasözlerinde yer alan pedagojik ifade ve anlamların belirlenmesi ve çağdaş pedagoji kuramlarıyla karşılaştırılarak kültür temelli bir yaklaşım önerisinin geliştirilebilmesidir. Atasözleri, geçmiş nesillerden diğer bir deyişle atalardan olduğu kabul edilen, anonim olan, toplumların asırlar boyunca edindiği tecrübeler ve gözlemleri belirten kısa, kalıplaşmış, özlü sözlerdir. Zamanın ve tecrübenin süzgecinden geçmiş durumların kısa cümlelerle ifadesi olan atasözleri göründüğünden daha geniş ve daha derin anlamlar taşımaktadır. Genel olarak pedagoji bilimi yönetimden programa, iletişimden tutuma insanın öğrenmesini, öğrenmeye dayalı düşünme ve davranışlarını konu edinmektedir. Üzerinde ayrıca zihinsel çaba sarf etmeye gerek kalmaksızın doğrudan sözel, duygusal ya da psiko-motor düzeyde ortaya çıkabilen davranışların kaynaklarından birisi de aile ortamında ve diğer çevresel etkileşimle atasözlerinden öğrenilenler, davranışlarımızın temel referanslarındandır. Dokuman incelemesi ve içerik analizi tekniğiyle analiz edilen atasözlerinde yer alan pedagojik ifade ve anlamlar belirlenmiş, bu ifade ve anlamlar Eğitim-Öğretim, Eğitim Psikolojisi, İletişim, Planlama ve Yönetim başlıklarında beş kategoride gruplandırılarak pedagojik açıdan yorumlanmıştır. Elde edilen sonuçlara dayalı Bilim Temelli Kültürel Milli Pedagoji Araştırması önerisi geliştirilmiştir.
Marka Güveninin Yüksek Fiyat Ödeme İstekliliği Üzerindeki Etkisinde Marka Aşkının Aracı Rolü: Kozmetik ve Kişisel Bakım Ürünleri Üzerine Bir Araştırma
Authors: SAYGILI Metin
Published: April 2023

Tüketicilerin satın alma kararında sektörde yer alan markalara yönelik tutumları ile birlikte söz konusu markalarla geliştirdikleri ilişkiler belirleyici olabilmektedir. Bu bağlamda tüketicilerin sağlık, güzellik ve estetik gibi insanların hem fiziki hem de duygusal gelişimine katkı sağlayan kozmetik ve kişisel bakım markalarına yönelik sevgi ve güven duyguları da ön plana çıkabilmektedir. Bu durum da tüketicilerin bu markalara yönelik yüksek fiyat ödeme istekliliğini artırmaktadır. Buradan hareketle bu çalışmanın amacı, marka güveni, marka aşkı ve yüksek fiyat ödeme istekliliği arasındaki ilişkileri araştırmaktır. Araştırmanın örneklemini, kolayda örnekleme yöntemi ile belirlenen kozmetik ve kişisel bakım ürünleri satın alan farklı sosyo-demografik özelliklere sahip 18 yaş ve üzeri tüketiciler oluşmaktadır. 575 katılımcıdan online anket yöntemiyle elde edilen verilerin analizinde doğrulayıcı faktör analizi (DFA) ve yapısal eşitlik modellemesi (YEM) kullanılmıştır. Araştırmada tanımlayıcı istatistiklerin oluşturulmasında SPSS 24.0 programı, YEM analizinde ise SmartPLS 4.0 kullanılmıştır. Elde edilen sonuçlar marka güveninin marka aşkı ve yüksek fiyat ödeme istekliliği üzerinde etkisi olduğunu göstermiştir. Ayrıca marka aşkının yüksek fiyat ödeme istekliliğini etkilediği tespit edilirken aynı zamanda marka güveninin yüksek fiyat ödeme istekliliği üzerindeki etkisinde marka aşkının aracı role sahip olduğu da bulunmuştur. Elde edilen sonuçlar, tüketicilerin kullanmayı sevdikleri kozmetik ve kişisel bakım ürünlerine yönelik yüksek fiyat ödeme istekliliğinde marka aşkı ve marka güveninin önemli belirleyiciler olduğunu ortaya koymuştur.
Were Career Expectations Realized? Examining the Careers of Tourism Management Graduates
Authors: YAŞAR Emre , ÖZTÜRK İsmail
Published: April 2023

The primary purpose of this study is to learn the career expectations of the individuals who graduated from the tourism management department before and after their education, and to investigate whether they have achieved success in their career expectations. The qualitative research method was adopted within the scope of the purpose of the study. A semi-structured interview form was prepared within the scope of the interview technique. There are five questions in the interview form. The purposive sampling was used in the study. Interviews were carried out with 19 graduates from the tourism management department. Interviews were conducted from September 10 to October 10, 2022. Content analysis was used in the written interview notes. As a result, themes and codes were created. These themes are reasons for preference, career expectations before and after graduation, career support, and career barriers. When the study findings are evaluated in general, the career expectations of individuals before and after graduation differ. It is observed that individuals who have career expectations for the sector have problems realizing their expectations. However, individuals who have career expectations outside the industry realize these expectations. Individuals with expectations for the tourism sector reduce their expectations to a low level after graduation. Individuals stated that they received the most support from family and university professors in their career expectations. In the obstacles individuals face, the hotel managers and the individuals themselves are at the forefront. Some suggestions have been developed within the scope of the study findings.
Origami Oyunlarıyla Yapılan Öğretimin 5. Sınıf Öğrencilerinin Geometriye Yönelik Tutumlarına Etkisi
Authors: ENGİN Ali Osman , DÜNDAR Bünyamin , ENGİN Mustafa Çağrı
Published: April 2023

Bu deneysel çalışmanın amacı, ortaokul 5.sınıf öğrencilerine uygulanan origami oyunlarıyla yapılan öğretimin öğrencilerin geometriye yönelik tutumlarına etkisi olup olmadığını belirlemektir. Araştırmada nicel araştırma yöntemlerinden ön test-son test, eşleştirilmiş kontrol gruplu yarı deneysel desen kullanılmıştır. Çalışmanın verileri 2021-2022 eğitim öğretim yılında “Geometri Tutum Ölçeği” ile toplanmıştır. Araştırmanın çalışma grubu Mardin ili Nusaybin ilçesinde devlete bağlı bir ortaokulun 21 kişilik iki sınıfında öğrenim gören toplamda 42 kişilik 5. sınıf öğrencilerinden oluşturulmuştur. Araştırma için bir sınıf deney ve bir sınıf kontrol grubu olarak seçilmiştir. Deney grubuna geometri alan ve uzunluk ölçme konusu origamiye dayalı 6 etkinlikle 5 hafta işlenirken, kontrol grubuna geleneksel yöntemlerle ders işlenmiştir. Uygulamanın öğrencilerin geometri tutumlarına etkisinin anlamlı olup olmadığını tespit için bağımlı ve bağımsız t-testleri yapılmıştır. Yapılan t-testleri sonucunda origami oyunlarıyla ve geleneksel yöntemle öğretim uygulandığı sınıflarda öğrencilerin matematik dersinde geometri konularına yönelik tutumlarında çok az değişmeler sağlanmıştır. Sonuç olarak iki grup arasında anlamlı fark elde edilememesi origami oyunlarıyla yapılan öğretimin geleneksel yöntemle yapılan öğretime göre öğrencilerin geometriye yönelik tutumlarını değiştirmede çok etkili olmadığını göstermiştir. Ancak origami uygulanan grubun deney öncesine göre kontrol grubuna göre tutumunda daha fazla değişiklik olmuştur.
The Impact of the Instability and Impunity Problem Associated with Ethnic Diversity on Regional Security: The Case of Dagestan
Authors: ALTINSOY Zeynep Deniz , DEĞER Filiz , AÇIKGÖZ Ali
Published: April 2023

Dagestan today is one of the most experienced republics in the North Caucasus Region concerning handling and familiarity with weapons. The most important factor in having this culture is the political crises and events that took place during the Soviet period. It is believed that the source of weapons in the country is Chechnya, and there have been historical reasons underlying this, as well as unique political institutions that have been developed in parallel with ethnic diversity since the 1990s. Based on the fact that the influence of the Russian Federation on other countries that left the Union of Soviet Socialist Republics (USSR) has not been lost even many years before the start of the Ukrainian-Russian war, the possibility of shaking the stability that Dagestan has relatively provided nowadays comes to the agenda. As much as the presence of these groups makes the people of Dagestan nervous, it threatens the entire geography in terms of the loss of stability in the region, the ignition of a significant conflict in the Caucasus, and, therefore, the countries of the region will also be affected by this conflict. Considering the political and ethnic structure of Dagestan, the government’s attempts to collect weapons, rather than maintaining order and increasing public security, cause a group with high conflict potential to collect weapons from the hands of another high-potential group, creating the perception that the tool of this is political power. This study is based on the data obtained by literature review with qualitative methods.
Потенциал Организации тюркских государств в обеспечении безопасности тюркского мира
Authors: APPASOVA Dinara
Published: April 2023

В глобализирующемся мире каждая страна сталкивается с угрозами национальной безопасности, такими как терроризм, экстремизм, сепаратизм и тд. В этом контексте, в то время как многие страны собираются под эгидой международных организаций, некоторые из них боряться за устранение выше упомянутых угроз в рамках многостороннего сотрудничества. Естественно, свою долю в этой ситуации получают и тюркские государства. Исходя из этого, целью данной статьи является исследование потенциала Организации тюркских государств в обеспечении безопасности тюркского мира. Для достижения цели статьи обсуждаются вопросы, угрожающие безопасности тюркского мира, и значение Организации тюркских государств с точки зрения обеспечения этой безопасности. В этом контексте, во-первых, пытались определить место тюркского мира в международной системе и влияющие на него факторы. Источником статьи являются ранее опубликованные статьи и работы отечественных и зарубежных исследователей по данной теме, данные официальных организаций, тексты официальных договоров и соглашений. Статья написана методом качественного исследования с использованием всех собранных данных и источников. В результате исследования, было установлено, что в целях обеспечения безопасности тюркского мира, были некоторые важные документы, в том числе документ «Концепция тюркского мира до 2040 года», были проведены ряд исследований, мероприятий такими организациями как TÜRKPA, TÜRKSOY и Тюркской академией в рамках Организации, для укрепления сознания «мы», которое составляет краеугольные камни безопасности.
The Place and Importance of Kyrgyzstan in Turkish Foreign Policy from a Constructivist Perspective
Authors: ARGALI Medihanur
Published: April 2023

Türkiye and Kyrgyzstan are two Turkic states with close historical, linguistic and cultural ties. In addition, although both states are secular, their people mostly belong to the same religion, the religion of Islam. Türkiye sees Kyrgyzstan as its Atayurt (fatherland) and in this context, it is the first state to recognize the independence of Kyrgyzstan in 1991. Of course, bilateral relations are too complicated to be explained by ancestry, language, or religion alone. Because the two countries have been out of contact with each other for many years. The first contact was made with the collapse of the USSR. Since 1991, the two states have developed and continue to develop various political, economic, military and cultural relations. This study will present a holistic analysis by examining the relations of the two states from a constructivist perspective, that is, in an identity sense. The main purpose of the study is to identify the current state of bilateral relations and offer solutions on how to further develop them. In the study, current data were examined by a literature review conducted in Turkish, English and Kyrgyz. The current data in question were analyzed by combining them with a constructivist perspective.
Coronary Artery Involvement in Kawasaki Disease-Echocardiographic Evaluation of Cases in a Tertiary Care Hospital
Authors: Fatema Nurun Nahar , Ferdous Jannatul , Chowdhury Ashik Raihan , Ahmad Mashiyat Mayisha
Published: April 2023

Background: Kawasaki disease (KD) is the leading cause of childhood acquired heart disease. Cardiovascular manifestations can be prominent in the acute phase of the illness. Echocardiography is useful in recognizing these cardiac manifestations. We carried out a retrospective study by analyzing the data of Kawasaki disease patients in a tertiary care hospital.
Methods: The prevalence of coronary artery dilatation and clinical outcome were documented. Clinical, laboratory, and echocardiographic findings were obtained at baseline and 1 week, 6 weeks after initial therapy with intravenous immunoglobulin in addition to high doses of Aspirin which reduces the risk of coronary artery aneurysm.
Results: One hundred and forty-nine patients with mean age 3± 2 years old, 60% males with Kawasaki disease were included. One hundred and thirty-two patients had coronary involvement (left main coronary artery 36.37 %, left anterior descending artery 28.03%, right main coronary artery 24.25%, circumflex branch in 11.37%). Administration of intravenous immunoglobulin (IVIG) and aspirin has greatly reduced the incidence of coronary lesions in affected children. The initial cardiac findings developed over first few weeks of illness resolved in most of the cases in the subsequent echocardiogram studies after IVIG. The mean duration to normalization of abnormal echocardiography findings is 6±3 months.
Conclusion: Coronary artery involvement is seen in most of children with Kawasaki disease. Intravenous gamma globulin and aspirin has been reported to reduce the likelihood of development of giant coronary artery aneurysms and appears to have a direct beneficial effect on abnormalities in cardiac function associated with the acute phase of Kawasaki disease.
Cardiovasc j 2023; 15(2): 144-150
Young Female’s Heart was Bitten by Unknown Ghost -Isolated Cardiac Sarcoidosis: A case report
Authors: Al Amin Heru , Quadir Rahatul , Islam Sk Ziarat , Patwary Md Shafiqur Rahman , Akbar Mohammad Shafiqullah , Khan Md Anisul Goni
Published: April 2023

Sarcoidosis is an inflammatory granulomatous disorder of unclear etiology that can affect multiple different organ systems. Isolated cardiac sarcoidosis is very rare condition which causes lethal arrhythmia and heart failure. A definite diagnosis of cardiac sarcoidosis remains challenging. The use of multimodality imaging plays a pivotal role in the diagnosis of this entity.
Cardiovasc j 2023; 15(2): 175-181
Análise das perspectivas municipais com a efetividade da arrecadação do IPTU no município de Dianópolis-TO
Authors: Pereira Kárita Carneiro , Guimarães Josiene Soares
Published: April 2023

O Imposto sobre a Propriedade Predial e Territorial Urbana – IPTU, de competência dos municípios, traz consigo uma responsabilidade para a gestão pública municipal em relação à arrecadação e destinação da sua receita. O presente trabalho tem como objetivo analisar a efetividade da arrecadação do IPTU em relação à perspectiva de aplicação da sua receita. Para tanto, realizou-se uma pesquisa qualitativa, de caráter exploratória, em relação aos seus objetivos. Os objetos do estudo foram a área tributária municipal, seus instrumentos legais e o comportamento da arrecadação, bem como os subsídios para o aprimoramento da gestão tributária na gestão municipal. Para a análise dos dados foi aplicada a técnica do método indutivo. Os principais resultados obtidos mostram que a gestão municipal precisa se aperfeiçoar quanto à atualização da sua legislação, bem como melhorar a receita arrecada com IPTU. Ao se comparar a despesa com a destinação dos valores arrecadados nos últimos três anos, percebeu-se que a receita ainda é muito baixa. Ademais, quanto à destinação da receita do IPTU, há previsão constitucional e infraconstitucional quanto a sua destinação especifica, bem como percentuais que podem ser empregados a qualquer despesa.
Evaluating Performance Indicators of Scientific Research Activities of Russian Federation's Regions
Authors: Rudnitskaya Anastasia , Akhmetova Gulnur , Burdakova Alexandra , Ilieva Svetlana , Komarov Nikolay
Published: April 2023

Introduction. The article discusses the findings of an evaluation of the effectiveness of research projects by federal districts of the Russian Federation and their regions using a variety of indicators, including resource endowment, infrastructure for science, participation of scientific organizations in the international scientific and educational community, funding, and costs. The information gathered helps assess the growth of scientific activities in particular Russian Federation regions and pinpoint the factors influencing those regions' rankings in the RIEPL rating. Monitoring Tools. The study used dynamic and comparative analysis, grouping, graphical and tabular methods of visualization, and economic-statistical analysis. Results. The findings of the study help assess the sufficiency of state and regional support for science and the position of the federal district in the Russian Federation in relation to the level of development of scientific infrastructure components and the funding level. Conclusion. The research can be used to optimize the regional scientific infrastructure and scientific and technical policy, as well as to form more balanced state measures in order to achieve the goals of the national project “Science and Universities”.
Evaluation of the Development of the Intellectual Property Field in the Russian Federation's Regions and Methodological Approaches
Authors: Byvshev Vladimir , Pisarev Ivan , Gubenko Diana
Published: April 2023

Introduction. The study is relevant given the need for the Russian Federation's regions to experience sustained socioeconomic growth based on innovation activity, the need to create enabling environ­ments for the domestic production of competitive goods and the establishment of knowledge-intensive industries amid the rising im­portance of import substitution and the adverse effects of the sanc­tions pressure from unfriendly countries. The study's objective is to evaluate the development of the intellectual property field across the Russian Federation. To achieve the study's objective, it is necessary to complete the following tasks: creating an algorithm for assessing the development of the intellectual property field in the regions; se­lecting a method for doing so; creating a system of indicators for the development of the intellectual property field in the regions; iden­tifying and evaluating the risks associated with the development of the intellectual property field in the regions; drawing conclusions re­garding the current situation. Methods. The article uses the integral assessment method to evaluate the development of the intellectual property field in the Russian Federation's regions. An evaluation of the scientific literature served as the foundation for the development of a system of indicators for measuring the development of the intellec­tual property field in the study's regions. We chose 18 areas of greatest interest for the assessment, computed their integral index, and pro­vided an interpretation of its results. Results and Discussion. The re­gions where the field of intellectual property is most developed and those where it is degrading were identified. Conclusion. Conclusions were drawn regarding the reasons why the Russian Federation's re­gions differ in terms of the degree of the intellectual property field's development.
Therapeutic targeting of anoikis resistance in cutaneous melanoma metastasis
Authors: Neuendorf Hannah M. , Simmons Jacinta L. , Boyle Glen M.
Published: April 2023

The acquisition of resistance to anoikis, the cell death induced by loss of adhesion to the extracellular matrix, is an absolute requirement for the survival of disseminating and circulating tumour cells (CTCs), and for the seeding of metastatic lesions. In melanoma, a range of intracellular signalling cascades have been identified as potential drivers of anoikis resistance, however a full understanding of the process is yet to be attained. Mechanisms of anoikis resistance pose an attractive target for the therapeutic treatment of disseminating and circulating melanoma cells. This review explores the range of small molecule, peptide and antibody inhibitors targeting molecules involved in anoikis resistance in melanoma, and may be repurposed to prevent metastatic melanoma prior to its initiation, potentially improving the prognosis for patients.
Electrocardiographic markers of atrial cardiomyopathy and risk of heart failure in the multi-ethnic study of atherosclerosis (MESA) cohort
Authors: Ahmad Muhammad Imtiaz , Mujtaba Mohammadtokir , Floyd James S. , Chen Lin Y. , Soliman Elsayed Z.
Published: April 2023

Background

The association of electrocardiographic (ECG) markers of atrial cardiomyopathy with heart failure (HF) and its subtypes is unclear.

Methods

This analysis included 6,754 participants free of clinical cardiovascular disease (CVD), including atrial fibrillation (AF), from the Multi-Ethnic Study of Atherosclerosis. Five ECG markers of atrial cardiomyopathy (P-wave terminal force in V1 [PTFV1], deep-terminal negativity in V1 [DTNV1], P-wave duration [PWD], P-wave axis [PWA], advanced intra-atrial block [aIAB]) were derived from digitally recorded electrocardiograms. Incident HF events through 2018 were centrally adjudicated. An ejection fraction (EF) of 50% at the time of HF was used to classify HF as HF with reduced EF (HFrEF), HF with preserved EF (HFpEF), or unclassified HF. Cox proportional hazard models were used to examine the associations of markers of atrial cardiomyopathy with HF. The Lunn-McNeil method was used to compare the associations in HFrEF vs. HFpEF.

Results

413 HF events occurred over a median follow-up of 16 years. In adjusted models, abnormal PTFV1 (HR (95%CI): 1.56(1.15–2.13), abnormal PWA (HR (95%CI):1.60(1.16–2.22), aIAB (HR (95%CI):2.62(1.47–4.69), DTNPV1 (HR (95%CI): 2.99(1.63–7.33), and abnormal PWD (HR (95%CI): 1.33(1.02–1.73), were associated with increased HF risk. These associations persisted after further adjustments for intercurrent AF events. No significant differences in the strength of association of each ECG predictor with HFrEF and HFpEF were noted.

Conclusions

Atrial cardiomyopathy defined by ECG markers is associated with HF, with no differences in the strength of association between HFrEF and HFpEF. Markers of atrial Cardiomyopathy may help identify individuals at risk of developing HF.
A remote sensing based method for assessing the impact of O3 on the net primary productivity of terrestrial ecosystems in China
Authors: Hu Lin , Wang Zhaosheng , Huang Mei , Sun Hongfu , Wang Qinyi
Published: April 2023

O3 pollution in China has been increasing in recent years, but the process of O3 impact on net primary productivity of terrestrial ecosystems remains unclear. We attempts to explore a remote sensing-based method to assess the impact of O3 on NPP of China’s terrestrial ecosystems by combining MODIS NPP and the latest ground observation data of O3 concentration. By comparing the NPP data of MODIS image pixels with the 6-year average AOT40 data of corresponding pixels, we extracted the signal data that highlighted the effects of O3 on NPP and established the response relationships between AOT40 and NPP. It was found that NPP was significantly negatively correlated with AOT40 in farmland and grassland ecosystems in China (farmland: r = 0.8674, p < 0.003, grassland: r = 0.7181, p < 0.03). Then the response relationships were adopted to evaluate the effect in China in 2014. The results showed that the estimated percentage of O3-induced NPP decline was in the range of 5%–35%. Among them, the most significant declines were found in farmland ecosystems, with the vast majority of declines in 10%–35%. The decrease rate of evergreen coniferous forests ranked second, mostly in the range of 15%–20%. The grassland ecosystems declined at a lower rate, almost between 5% and 15%. And the evergreen broad-leaved forests has the lowest decline rate, most distributed in 0%–5%. The highest percentage decreases were mainly found in the Beijing-Tianjin-Hebei region and Shandong Province. And the decline rate of farmland ecosystems was significantly higher than other ecosystem types.
A new primitive polychaete with eyes from the lower Cambrian Guanshan biota of Yunnan Province, China
Authors: Zhao Jun , Li Yujing , Selden Paul A.
Published: April 2023

Annelids are abundant and speciose in the modern world but are comparatively few in the fossil record. Primitive annelids were expected to have developed eyes and nuchal organs, but until now definitive evidence is still lacking. Based on a new specimen from the Wulongqing Formation, we describe Gaoloufangchaeta bifurcus gen. et sp. nov. from the Guanshan biota (Cambrian Series 2, Stage 4) of Yunnan province, China. The overall profile of the body and the presence of tentacles and stout parapodia with simple chaetae establish it as a primitive polychaete. By bearing bicellular eyes and possible nuchal organs, the new form has developed relatively strong sensory abilities. Our material further confirms that polychaetes were already diverse by Cambrian Series 2, indicating a much earlier origin for the group.
Paget’s disease: a review of the epidemiology, etiology, genetics, and treatment
Authors: Banaganapalli Babajan , Fallatah Ibrahim , Alsubhi Fai , Shetty Preetha Jayasheela , Awan Zuhier , Elango Ramu , Shaik Noor Ahmad
Published: April 2023

Paget’s disease of bone (PDB) is the second most prevalent metabolic bone disorder worldwide, with a prevalence rate of 1.5%–8.3%. It is characterized by localized areas of accelerated, disorganized, and excessive bone production and turnover. Typically, PDB develops in the later stages of life, particularly in the late 50s, and affects men more frequently than women. PDB is a complex disease influenced by both genetic and environmental factors. PDB has a complex genetic basis involving multiple genes, with SQSTM1 being the gene most frequently associated with its development. Mutations affecting the UBA domain of SQSTM1 have been detected in both familial and sporadic PDB cases, and these mutations are often associated with severe clinical expression. Germline mutations in other genes such as TNFRSF11A, ZNF687 and PFN1, have also been associated with the development of the disease. Genetic association studies have also uncovered several PDB predisposing risk genes contributing to the disease pathology and severity. Epigenetic modifications of genes involved in bone remodelling and regulation, including RANKL, OPG, HDAC2, DNMT1, and SQSTM1, have been implicated in the development and progression of Paget’s disease of bone, providing insight into the molecular basis of the disease and potential targets for therapeutic intervention. Although PDB has a tendency to cluster within families, the variable severity of the disease across family members, coupled with decreasing incidence rates, indicates that environmental factors may also play a role in the pathophysiology of PDB. The precise nature of these environmental triggers and how they interact with genetic determinants remain poorly understood. Fortunately, majority of PDB patients can achieve long-term remission with an intravenous infusion of aminobisphosphonates, such as zoledronic acid. In this review, we discuss aspects like clinical characteristics, genetic foundation, and latest updates in PDB research.
Adenovirus Encoded Adjuvant (AdEnA) anti-CTLA-4, a novel strategy to improve Adenovirus based vaccines against infectious diseases and cancer
Authors: D’Alise Anna Morena , Nocchi Linda , Garzia Irene , Seclì Laura , Infante Luigia , Troise Fulvia , Cotugno Gabriella , Allocca Simona , Romano Giuseppina , Lahm Armin , Leoni Guido , Sasso Emanuele , Scarselli Elisa , Nicosia Alfredo
Published: April 2023

Introduction

Virus vectored genetic vaccines (Vvgv) represent a promising approach for eliciting immune protection against infectious diseases and cancer. However, at variance with classical vaccines to date, no adjuvant has been combined with clinically approved genetic vaccines, possibly due to the detrimental effect of the adjuvant-induced innate response on the expression driven by the genetic vaccine vector. We reasoned that a potential novel approach to develop adjuvants for genetic vaccines would be to “synchronize” in time and space the activity of the adjuvant with that of the vaccine.

Methods

To this aim, we generated an Adenovirus vector encoding a murine anti-CTLA-4 monoclonal antibody (Ad-9D9) as a genetic adjuvant for Adenovirus based vaccines.

Results

The co-delivery of Ad-9D9 with an Adeno-based COVID-19 vaccine encoding the Spike protein resulted in stronger cellular and humoral immune responses. In contrast, only a modest adjuvant effect was achieved when combining the vaccine with the same anti-CTLA-4 in its proteinaceous form. Importantly, the administration of the adjuvant vector at different sites of the vaccine vector abrogates the immunostimulatory effect. We showed that the adjuvant activity of Ad-α-CTLA-4 is independent from the vaccine antigen as it improved the immune response and efficacy of an Adenovirus based polyepitope vaccine encoding tumor neoantigens.

Discussion

Our study demonstrated that the combination of Adenovirus Encoded Adjuvant (AdEnA) with an Adeno-encoded antigen vaccine enhances immune responses to viral and tumor antigens, representing a potent approach to develop more effective genetic vaccines.
Structural changes upon membrane insertion of the insecticidal pore-forming toxins produced by Bacillus thuringiensis
Authors: Pacheco Sabino , Gómez Isabel , Peláez-Aguilar Angel E. , Verduzco-Rosas Luis A. , García-Suárez Rosalina , do Nascimento Nathaly A. , Rivera-Nájera Lucero Y. , Cantón Pablo Emiliano , Soberón Mario , Bravo Alejandra
Published: April 2023

Different Bacillus thuringiensis (Bt) strains produce a broad variety of pore-forming toxins (PFTs) that show toxicity against insects and other invertebrates. Some of these insecticidal PFT proteins have been used successfully worldwide to control diverse insect crop pests. There are several studies focused on describing the mechanism of action of these toxins that have helped to improve their performance and to cope with the resistance evolved by different insects against some of these proteins. However, crucial information that is still missing is the structure of pores formed by some of these PFTs, such as the three-domain crystal (Cry) proteins, which are the most commercially used Bt toxins in the biological control of insect pests. In recent years, progress has been made on the identification of the structural changes that certain Bt insecticidal PFT proteins undergo upon membrane insertion. In this review, we describe the models that have been proposed for the membrane insertion of Cry toxins. We also review the recently published structures of the vegetative insecticidal proteins (Vips; e.g. Vip3) and the insecticidal toxin complex (Tc) in the membrane-inserted state. Although different Bt PFTs show different primary sequences, there are some similarities in the three-dimensional structures of Vips and Cry proteins. In addition, all PFTs described here must undergo major structural rearrangements to pass from a soluble form to a membrane-inserted state. It is proposed that, despite their structural differences, all PFTs undergo major structural rearrangements producing an extended α-helix, which plays a fundamental role in perforating their target membrane, resulting in the formation of the membrane pore required for their insecticidal activity.
Complete mitochondrial genomes of the “Acmaeidae” limpets provide new insights into the internal phylogeny of the Patellogastropoda (Mollusca: Gastropoda)
Authors: Putri Eggy Triana , Lee Damin , Kwak Haena , Kim Yukyung , Nakano Tomoyuki , Park Joong-Ki
Published: April 2023

The subclass Patellogastropoda (called “true limpets”) is one of the most primitive groups of the Gastropoda and contains approximately 350 species worldwide. Within this subclass, internal phylogeny among family members, including relationships of the “Acmaeidae” with other patellogastropod families, remains incompletely clarified. Here, we newly determined two complete mitochondrial genome sequences of “Acmaeidae” (Acmaea mitra and Niveotectura pallida) and one sequence from Lottiidae species (Discurria insessa) and combined them with mitochondrial genome sequences of 20 other published limpet species for phylogenetic analysis of the sequence dataset (nucleotides and amino acids) of 13 protein-coding genes using maximum likelihood and Bayesian inference methods. The resulting phylogenetic trees showed monophyly of Patellogastropoda species that were subsequently subdivided into two clades [clade I (Nacellidae, Pectinodontidae, Acmaeidae, and Patellidae) and clade II (Eoacmaeidae and Lottiidae)]. The sister relationship between the Acmaeidae and Pectinodontidae species revealed by phylogenetic analysis was also supported by sharing their similar gene arrangement patterns, which differ substantially from those of clade II members including the Lottiidae species. The polyphyletic relationship between Acmaeidae (grouped with Pectinodontidae as a sister taxon in clade I) and Lottiidae species (grouped with Eoacmaeidae in clade II) corroborates that they are phylogenetically distinct from each other. This mitochondrial genome phylogeny contradicts previous morphology-based hypotheses, yet highlights that Acmaeidae and Pectinodontidae are the most closely related. Further in-depth analysis of the complete mitochondrial genome sequences based on a broad range of samples including those from relatively unstudied and/or underrepresented taxa is required to fully understand the mitochondrial genome evolution and a more comprehensive phylogeny among the major groups of the Patellogastropoda.