bluuebunny/crossref_metadata_2025 huggingface dataset:
Local Chinese Dialects and Toponymity of Chinese Streets in Sibu, Sarawak
Authors:   Universiti Putra Malaysia, Malaysia, Yann Wong Ling
Published: March 2021

This paper aims to explore into the categories, structural formation, syllables and alphabetic characteristics of the naming of Chinese streets in Sibu, Sarawak. Sibu is the third biggest city in Sarawak, is also called “New Foochow” or “Little Foochow”. The Foochow people is one of the main ethnicities in Sibu. The Foochow culture and dialect play an important role in developing the history of Sibu. One of the significant influences of the Foochow culture and dialect towards the history of Sibu is the naming of the city streets in Chinese. This study adopts a qualitative research methodology to collect and analyse research data, where a historical comparative study is adopted to study the naming categories, the structural formation, syllables and alphabetic characteristics of the Chinese streets in Sibu.
Compliment Strategies Employed by Japanese and Malaysian Tour Guides during Tour Sessions
Authors:   Universiti Malaysia Terengganu, Malaysia, Rashid Roswati Abdul , Mamat Roslina ,   Universiti Putra Malaysia, Malaysia, Paee Rokiah ,   Universiti Malaysia Sarawak, Malaysia
Published: March 2021

This research is a comparative study of Japanese language communication between the Japanese and Malay tourist guides during tourism tour sessions. The research goal is to examine patterns of compliment strategies implemented throughout the interactions of the tour sessions. The study results acquired are in the form of four recordings of a dialogue between the tourist guides and the tourists, in audio and video modes. The conversations are transcribed and coded. The tour guides included two Japanese native speakers and two Malaysian-Japanese speakers. In contrast, the tourists are Japanese native speakers who visited Malaysia, and Malaysians who attended the tourist attractions in Japan. The study reveals that the frequency of compliments applied by both Japanese and Malaysian tour guides are alike, or in other words, there are no significant differences. Nevertheless, category, function and topic or theme of compliment utterance present ssubstantial distinction.
From Upland to Lowland: Karen Learners’ Positioning and Identity Construction through Language Socialization in the Thai Classroom Context
Authors:   Rajabhat University, Thailand, Jawaut Nopthira , Dumlao Remart ,   Rajabhat University, Thailand
Published: March 2021

Karen (or Kariang or Yang) are a group of heterogeneous ethnic groups that do not share common culture, language, religion, or material characteristics, and who live mostly in the hills bordering the mountainous region between Myanmar and neighboring countries (Fratticcioli 2001; Harriden 2002). Some of these groups have migrated to Thailand’s borders. Given these huge numbers of migrant Karens, there is a paucity of research and understanding of how Karen learners from upland ethnic groups negotiate and construct their identities when they socialize with other lowland learners. This paper explores ways in which Karen learners negotiate and construct their identities through language socialization in the Thai learning context. The study draws on insights from discourse theory and ecological constructionism in order to understand the identity and negotiation process of Karen learners at different levels of identity construction. Multiple semi-structured interviews were conducted to gain deeper understandings of this phenomenon between ethnicity and language socialization. The participants were four Karen learners who were studying in a Thai public university. Findings suggest that Karen learners experience challenges in forming their identity and in negotiating their linguistic capital in learning contexts. The factors influencing these perceptions seemed to emanate from the stakeholders and the international community, which played significant roles in the context of learning. The findings also reflect that Karen learner identity formation and negotiation in language socialization constitutes a dynamic and complex process involving many factors and incidences, discussed in the present study. The analysis presented has implications for immigration, mobility, language, and cultural policy, as well as for future research.
Inovasi Pelayanan Administrasi Nikah Terintegrasi di Kantor Urusan Agama Kecamatan Enam Lingkung Kabupaten Padang Pariaman
Authors: Alindro Nugi , Kusdarini Kusdarini , Putera Roni Ekha
Published: March 2021

Purpose of this study to describe the Integrated Marriage Administration Service Innovation (PANTER) by KUA Kecamatan Enam Lingkung, Padang Pariaman. Public service innovation doesn’t not require a something new, but can be a new approach in contextual at the sense that innovation not limited from there are ideas and practicies of innovation but can be in the form of innovation resulting from expansion or quality improvement of existing innovations. This research is using descriptive approach by qualitative methods. Technique of collecting the data was by interview and documentation.This study is motivated by good will from Head of KUA Kecamatan Enam Lingkung to make easier community of Enam Lingkung District to get some documents and to assist Disduckcapil Kabupaten Padang Pariaman in orderly administration. The result of this study is PANTER helped community to obtaining marriage documents and population documents  like Nationality ID, Family Register, and Nationality Health Insurance without spending money and time. However, there are still some problem faced by the community and PANTER officer, such as lack of facilities and infrastructure, lack of PANTER officer and unstable internet networks.
Model Pengadaan CPNS Masa Bencana Nasional Non Alam
Authors: Daniarsyah Dida , Rusdi Rusdi
Published: March 2021

This article tries to analyze the problems of business processes procurement of Candidate of Civil Servant (CPNS) during the Covid-19 pandemic. The formulation of research problems is that business process services of CPNS at the Ministry of Marine Affairs and Fisheries are less effective during pandemics. Problems found in the field include the inefficiency of time in business processes of recruitment and selection subprocesses. This study uses qualitative descriptive approach with empirical study method at the Ministry of Marine Affairs and Fisheries. Adoption of technology utilization, recruitment and selection procedures based on the needs of priority positions, business process of selection time is not simultaneous, intensive coordination business process between implementing agencies and responsible agencies can be a model of business processes procurement CPNS non-natural national disaster period
Percepatan Reformasi Birokrasi Melalui Budaya Keterbukaan Informasi di Daerah Istimewa Yogyakarta
Authors: Suryani Dewi Amanatun , Saharuddin Erni
Published: March 2021

Public services in Indonesia have many complaints from the public due to unclear procedures, limited access to information, and inadequate infrastructure. The enactment of the Law on Public Information Disclosure gives the public the right to supervise governance and improve the quality of information management and services within the Public Agency. The DIY Regional Government PPID which has been established since 2013 has not shown good performance. The purpose of this study was to analyze the performance of PPIDs and the factors that influence the acceleration of bureaucratic reform to create a culture of information openness. Performance evaluation is measured based on aspects of productivity, service quality, responsiveness, responsibility, and accountability. Meanwhile, the influencing factors are seen from personal / individual, leadership, team, system, and contextual (situational) factors. This research method uses a qualitative descriptive approach. The data collection technique is done through interviews, observation, and documentation study. An important finding from the performance evaluation results is that PPID productivity and accountability are still low. Meanwhile, factors that hinder performance are limited understanding of PLID, lack of intensity of communication between the Regional Head and Assistant PPIDs and the absence of budget support for PPID. Strategies that need to be carried out include improving the quality of PPID service performance by compiling a community satisfaction index, updating the classification of information regularly, monitoring and evaluation by giving awards and punishment, improving personality and utilizing various social media.
KUALITAS BACA AL-QUR’AN ANAK
Authors: Wiayanti Euis Dewi , Mu’tamariah Imas Musyaropah Ilham
Published: March 2021

Reading the Qur'an for Muslims is worship to Allah SWT. Forthat a child must be given understanding and familiarized to recite theQur'an from an early age. Reading the Qur'an does not give priority tothe absorption and understanding through the transfer of informationalone, but more priority on the development of ability. For that theability of learners need to be developed through active roles andexercises or activities that can support the ability to read Al-Qur'an. Inreading the Quran the quantity and quality go hand in hand. Which isthe best thing, all back to the condition of the child who read it. If thereading is good, of course the better for him is the quantity As for thechild who is not smooth, the best for him is the quality of reading theQur'an is still very minimal to find a quality child in reading the Quran.Many of the Muslims who read Al-Quran are not yet fluent, let aloneknow the correct rules of tajwid.
PENDIDIKAN KEIMANAN ANAK DALAM KELUARGA MENURUT ZAKIAH DARADJAT
Authors: Muslimawaty Rivanti
Published: March 2021

Many parents do not understand the concept of faith education inchildren. This could be based on an assumption that children are stilltoo young to be educated in matters of faith. Whereas the family, in thiscase the parents, is an educational institution that is directly related tothe child since he was born. So there is a thought that the family isbelieved to have a very strong influence on children’s religiouseducation. This happens because the relationship that exists betweenparents and children for 24 hours is very important in education.Zakiah Daradjat is an education expert who also believes that theimportance of faith education is given to children as early as possible,so the purpose of this study is to find out how Zakiah Daradjat’sthoughts about children’s religious education are in the family. Byusing qualitative research methods, the author seeks to explain theeducation of children’s faith in the family according to ZakiahDaradjat. The author found that Zakiah Daradjat had clear thoughtsabout children’s religious education in the family, which aims to makechildren as human beings, through the six pillars of faith, with methodsof exemplification, habituation, wrong correction, erroneous quarrelsthat occur and reminding the forgotten. The evaluations carried out inthe form of memorization tests, tests of understanding and practice ofworship. This makes Zakiah Daradjat’s thoughts still relevant to beapplied in today’s life and become a reference for psrents, teachers abdother related parties.
PERSEPSI GURU TERHADAP PENGARUH SUVERVISI KEPALA SEKOLAH DAN MOTIVASI KERJA TERHADAP KINERJA GURU DI SMP NEGERI KECAMATAN CIMERAK KABUPATEN PANGANDARAN
Authors: Nurmalasari Neneng
Published: March 2021

This article aims to determine the effect of supervision of Head master toward teacher performance, determine the influence of teacher work motivation toward teacher performance, and determine the influence of Head master supervision and teacher’s work motivation classically toward teacher performance. The method used is descriptive analysis method. It will hopefully be able to understand the problem based on the phenomenon at the time of the study. The subjects of this study were 120 State Teachers in Cimerak Subdistrict, Pangandaran Regency, with a total sample of 75 teachers. While the object of this study is the supervision of the principal, work motivation of teachers, and teacher performance. The data collected in this study were captured through a questionnaire in the form of scales in the range of scores from 1 to 5. The result of research is : 1) the effect of school principal supervision (X1) on Teacher Performance (Y) of 0.091; 2) the effect of teacher work motivation (X2) on teacher performance (Y) of 0.139; and 3) the influence of school principal supervision (X1) and teacher work motivation (X2) on teacher performance (Y) together by 0.165, meaning 0.835 is the influence of factors other than those examined.
EŞ‘ARÎ EKOLÜNDE ALLAH TASAVVURU
Authors: ÇINAR Bayram
Published: March 2021

Özet

Bu çalışma Eş‘arî mezhebinin, tanrı tasavvurunu sunmayı amaçlar. İslam dindarlığının teolojik anlayışının alandaki yaygınlığı sebebiyle belirleyen Eş‘arî ekolün Allah tasavvuru, Müslümanlar arasındaki Allah tasavvurunu da ortaya çıkaracak bir öneme sahiptir. Çünkü Mu‘tezile sonrası dönemdeki biçimi ile İslam Kelam tarihi, bir yönüyle Eş‘arî ekolünün tarihidir. Eş‘arî kendi yaşamının önemli bir bölümünü Mu‘tezile mezhebi içerisinde geçirmiş, fakat muhtemelen bu ekolün teolojik yorumlarını kendisi için yeterli görmeyerek bu mezhepten ayrılmış ve kendi mezhebini kurmuştur. Onun Mu‘tezile ekolünün diyalektiğine olan yakınlığı, onların terminolojisine ilişkin bilgisi, kendi teolojik çabalarında görülür. Buna ek olarak, o Mu‘tezile'ye kendi ekolü içerisinde “öteki” olarak ele almış, kendisine karşı söylem geliştirilen ekol olarak yer vermiştir. Dolayısıyla Eş‘arî ekole ilişkin her teolojik çalışma bir yönüyle de Mu‘tezilî bir çalışmadır. Daha anlaşılır bir ifade ile Eş‘arî ekole ilişkin her araştırmanın bir Mu‘tezilî okuma olduğu da bu yüzden söylenebilir.

Çalışmamızda yalnızca Eş‘arî ekole ilişkin değerlendirmelere yer verilmiş, mümkün olduğunca diğer ekollerin değerlendirmelerinden kaçınılmıştır. Çalışmada Gazzâlî’nin doktrine ilişkin değerlendirmeleri ise öne çıkmıştır. Bunun nedeni onun konuya ilişkin yoğun ve yaygın materyali eserlerinde bulundurması ile sınırlıdır.
İNTERNET BAĞIMLILIĞI VE SAĞLIK ANKSİYETESİNİN SİBERKONDRİ DAVRANIŞLARI ÜZERİNE ETKİSİ
Authors: DOĞAN Sermed , ACAR Füsun , BAYNAL DOĞAN Tuğba Gül
Published: March 2021

Teknolojik araçların yaygın bir şekilde kullanımı ile insanların sağlık sorununa ilişkin kaygılarında ilk başvuru yapılan bilgi kaynağı arasında internet verisi yer almaktadır. Burada amaçlanan durum, semptomların ciddi bir hastalık belirtisi olmadığı hakkında bir yargıya ulaşmaktır. Ancak önemli bir sağlık sorunu olduğuna ilişkin kaygı seviyesini azaltma girişimi, internetten hastalık arama sonucunda daha yüksek seviyede stres, kaygı ve depresyon sergileme tutumunu da artıracağı düşünülmektedir. Bu durumun ise internette aşırı zaman geçirme ya da internet bağımlılığı boyutuna ulaşan bireylerde kaygı düzeyi ile birlikte çevrimiçi hastalık arama sürecinde etken olup olmadığı bilinmemektedir. Bu nedenle araştırma internet bağımlılığı ve sağlık anksiyetesinin siberkondria üzerine etkisini incelemeyi amaçlamaktadır. Araştırma bulgularında internet bağımlılığı (r=0.224), sağlık anksiyetesi (r=0.274) ve siberkondria davranışının (r=0.508)karşılıklı ilişki içerisinde olduğu belirlenmiştir. Ayrıca hiyerarşik regresyon analizi sonucunda ise internet bağımlılığı (β=0.17, p
ÇAĞDAŞ SERAMİK SANATINDA FARKLI MALZEME KULLANIMI
Authors: YILDIRIM Burak
Published: March 2021

Tarih öncesi çağlardan beri süregelen seramik üretiminde ortalama 20. yüzyıldan itibaren çağdaş yönelimler başlamış, önceleri yeme-içme-saklama kapları ve birtakım dinsel seramikler, figüratif heykelcikler üretilen salt seramik malzeme ile giderek artan şekilde estetik kaygı ve sanatsal gaye arayışında olan formlar/eserler üretilmeye başlanmıştır.

Yaşadığımız çağda seramik eserlerin üretim aşamalarında; sonradan somut varlığı üzerinde kalmayacak, sadece izi/dokusu/etkisi kalacak olan dâhili farklı malzemeler kullanılmaya başlanmıştır. Ayrıca yine seramik eserlerin üretim aşamalarında ya da sonradan somut varlığı kalacak olan harici farklı malzemeler kullanılmaya başlanmıştır. Günümüzde seramik eser üretiminde, öğütülerek/parçalanarak şekillendirme yapılacak çamur içerisine katılan; kemik tozu/külü, hayvan tüyleri/kılları, kağıt türevleri, odun talaşı, kumaş parçaları gibi malzemeler ve özellikle döküm çamuruna batırılarak ya da üzerine çamur kaplanarak, çamurun ona özgü şekli/dokuyu alması sağlanan kumaş, sünger, örgü vb. tekstil malzemeler, seramik sanatında dâhili farklı malzeme kullanımına örnek olarak verilebilir. Ayrıca seramik forma çoğunlukla deri sertliği aşamasında doku vermek, dekor yapmak, iz bırakmak amacıyla kullanılan dantel/örgü ve bitki yaprakları gibi organik ya da inorganik her türlü malzemeler dâhili farklı malzeme kullanımı tanımlaması kapsamına alınabilir. Seramik esere üretim aşamalarında veya sırlı fırın aşamasından sonra eklenen demir talaşı, metal, taş, ağaç, ahşap, tekstil, ışık, video, ekran vb. her türlü somut farklı malzemelerde seramik sanatında harici farklı malzeme kullanımına örnek gösterilebilir.

Günümüz çağdaş seramik sanatında; dâhili ve harici olarak belirtilen her iki farklı malzeme kullanım şekli de oldukça yaygındır. Ancak harici farklı malzeme kullanımının, giderek artan şekilde daha çok ön plana çıktığı söylenebilir. Bu araştırmada çağdaş seramik sanatında farklı malzeme kullanımı konusu irdelenerek konu ile ilgili bazı çağdaş sanatçıların örnek niteliğinde olduğu düşünülen eserlerinin tanıtımına yer verilecektir.
İMGE ORMANINDAN MATRİSE SÖZCÜKTEN ANLAMA ŞİİR DİLİNİN AURASI
Authors: SOMUNCUOĞLU ÖZOT Gamze
Published: March 2021

Şiir dili, içinde barındırdığı özgün iletişim kanalları nedeniyle yazın dünyasında özel olarak ele alınması ve irdelenmesi gereken bir yapı arz etmektedir. Az sözle çok metne göndermeler yapabilen bu tür içerisinde imge ve ahenk unsurları belki de şiiri gündelik dilden ya da düz yazı dilinden farklılaştıran ve yeni bir dil oluşturan başat unsurlardır. Şiir, şairin kaleminden çıktığı haliyle kalmaz, her okunuşta, her okurda çoğalan, yayılan, anlamlanan bir oluşumdur. Çok bilinmeyenli imgeler sistemindeki şiirlerin çözümlemeleri yapılırken sistematik bir yaklaşım sergilemek kaçınılmazdır. Şiirin anlam katmanlarının doğru bir şekilde değerlendirilebilmesi için geliştirilmiş kuramsal yaklaşımlar mevcuttur. Türk şiir dili üzerine yapılan akademik çalışmalarda bu konunun derin bir şekilde ele alınması ve kendi edebiyatımıza has kuramsal yaklaşımların çoğaltılması elzemdir. Sözü edilen konuya ilişkin dünya yazınında itibar görmüş bazı tekniklerin tanıtılmasını da kapsayan bu araştırmada şiirde imge ve ahenk gibi derin konuların kapısı aralanmaya çalışılmıştır. Şiiri şiir yapan başat prensip olan imgelerin şiir zeminine ayaklarının doğru bir biçimde yerleştirilmesi ve -Poe’nun “Kuzgun”u oluştururken yaptığı gibi- ikinci aşamada da ritmin güçlü bir şekilde şiir diline uygulanabilmesi sonucunda güçlü bir şiirsel söylem ortaya konulabildiği görülmüştür.
marcel duchamp ve gunahı
Authors: SELÇUK Evren
Published: March 2021

Bu çalışmanın amacı Dadanın temsilcilerinden Marcel Duchamp’ın radikal sanat anlayışının; kendisinden sonraki sanatı nasıl etkilediğini ve günümüz sanat üretimlerinde yarattığı olumlu ve olumsuz etkileri araştırmaktır. Bu amaçla I. Dünya savaşı yıllarında ortaya çıkan bir akım olan Dada’nın sanat anlayışı ve sanatçı profili, buna bağlı olarak Dada’nın ilk akla gelen isimlerinden biri olan Marcel Duchamp’ın üretme ve düşünme pratiği ve de Duchamp’ın üretimlerinin yarattığı etkiyle ortaya çıktığı ve ilişkili olduğu düşünülen tekrara dayalı ve yaratıcılıktan uzak olduğu ispat edilmeye çalışılan bazı örnekler üzerinde durulmuştur. Örnekler analiz edilirken -her defasında Duchamp’ı referans göstererek- Andy Warhol, Jeff Koons ve Yayoi Kusama’nın üretimlerinde nelerin görünür olduğuna, Duchamp’tan sonra birçok sanatçıda görülebilen aynının tekrarına dayalı biçim odaklı bir dil geliştirildiğine ve buna bağlı olarak her defasında kendini yineleyen ve dolayısıyla kısır hale gelen üretim alışkanlıklarının sanatsal söylemi çökerttiğine işaret edilmiştir.

Duchamp’ın sanatta birçok sınırı ortadan kaldırdığı, geleneksel kalıplara meydan okuduğu, üretme biçimlerine dair potansiyelleri arttırdığı, sanatta biriciklik, kutsallık gibi kültleri yıktığı ve aynı zamanda malzeme ve tekniğe dair yeni bir bakış açısı getirdiği görülmüştür. Böylece her şeyin sanat olabilme potansiyeli ve sonsuz bir özgürlük alanı ortaya çıkmıştır. Ancak bu anlayış, -genelleme yapmak mümkün olmasa da- bugün sanatta tekrara dayalı ve sıradan bir dili beraberinde getirmiştir.

Bu anlamda bu makalede Duchamp önemli ve olumlu bir noktaya konulurken; “günah” bir metafor olarak kullanılmış ve o zamandan bugüne sanatın suçlusu olarak Duchamp’a işaret edilmiştir. Bu süreçte basılı ve elektronik kaynaklardan faydalanılmış, sanata ve tarihine dair çeşitli görüşlere yer verilmiş ve bazı ikonik sanat yapıtları üzerinde durulmuştur.
EVALUASI PELAKSANAAN PROGRAM PENGEMBANGAN PERUMAHAN (STUDI PADA KANTOR DINAS PERUMAHAN DAN KAWASAN PERMUKIMAN KOTA PALEMBANG)
Authors: Yuliana Yuliana
Published: March 2021

Housing and settlements are basic human needs. Therefore, the government is trying to meet the community's need for housing. This study aims to see how the housing development program is implemented in Palembang City, monitor this program and also monitor the extent of the housing development program. This research uses descriptive qualitative techniques with interviews. Key information is the Head of the Palembang City Housing and Settlement Area Office, the Head of the Housing and Settlements Section, the Head of the Palembang City Development Planning Agency, and Housing Developers in Palembang City, as well as people living in housing in Palembang City. Then the data obtained from the study were analyzed using qualitative descriptive analysis methods. The results showed that the implementation of the housing development program in Palembang City has not been carried out properly in accordance with what has been planned by the Palembang City Government.
Network analysis of the effects of long non-coding RNAs in artemisinin treatment of atherosclerosis in APOE–/– mice
Authors: Qiao Zhao , Hongjiao Du , Xiaodong Li
Published: March 2021

Introduction

Atherosclerosis has become a worldwide medical burden. Our previous studies have shown that artemisinin (ART) had the capability to reduce atherosclerosis. Emerging evidence indicates that long non-coding RNAs (lncRNAs) are involved in the development of atherosclerosis. However, whether lncRNAs might participate in the mechanism through which artemisinin mitigates atherosclerosis has not been reported.

Material and methods

Eight-week-old apolipoprotein E deficient (APOE–/–) mice were divided into two groups, one of which was treated with artemisinin. Red oil O staining was used to measure the sizes of the atherosclerotic lesions. We conducted deep sequencing to investigate lncRNA profiles in the aorta tissue in high-fat diet fed APOE knockdown mice with and without artemisinin treatment. CeRNA network, Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) analyses were performed through bioinformatics analysis. RT-PCR was used to validate the differentially expressed lncRNAs.

Results

A total of 102 lncRNAs and 4,630 mRNAs were differentially expressed (p < 0.05) between the artemisinin treatment group and atherosclerosis model group. KEGG and GO analyses indicated that the categories metabolic process, specific amino acid degradation and PI3K-Akt signaling pathway are involved in the effects of artemisinin treatment in atherosclerosis (q < 0.05). LncRNA ENSMUST00000099676.4, ENSMUST00000143673.1, ENSMUST00000070085.5 and ENSMUST00000224554 might be engaged in the treatment mechanism through which artemisinin alleviates atherosclerosis.

Conclusions

These findings indicated the possible mechanism and therapeutic role of lncRNAs in artemisinin treatment of atherosclerosis and provided a theoretical basis for the future application of artemisinin in patients with atherosclerosis.
microRNA-223-3p attenuates angiotensin II-dependent ROS effect on cell viability by targeting NLRP3 in H9c2 cells
Authors: Dai Weiran , Zhou Shuang , Zhong Guoqiang , Jiang Zhiyuan
Published: March 2021

Introduction

Recently, enhanced activation of NLRP3 has been reported to be involved in atrial fibrillation (AF). This study aimed to detect the correlation between oxidative stress and NLRP3 and explore the role of miR-223-3p in the injury of ROS induced by Ang II.

Material and methods

Serum Ang II levels were examined by ELISA kit. Fibrosis levels of right atrial appendages were determined by Masson’s staining. H9c2 cells tansfected with miR-223-3p mimics were treated with Ang II with or without MCC950 (a potent selective NLRP3 inhibitor). Cell viability was detected by CCK-8 assay. Protein abundance was detected by Western blot. MDA assay and DCFH-DA were used to measured oxidative stress. RT-qPCR was used to assay the expression of miR-223-3p and NLRP3.

Results

Totally, 43 patients enrolled in this study, including 20 patients with persistent (chronic) AF (cAF). Comparing with sinus rhythm (SR) group, we found an enhanced activation of NLRP3 inflammasome which were positively correlated with oxidative stress and serum Ang II level in cAF patients. Ang II induced ROS generation and inhibited the H9c2 cell viability. In addition, overexpression of miR-223-3p functioned as MCC950 which inhibited the expression of NLRP3 inflammasome and partly attenuated the effects of ROS induced by Ang II on H9c2 cell viability. Lastly, we used luciferase assay to confirm NLRP3 as a direct target gene of miR-223-3p.

Conclusions

miR-223-3p has protective effects on oxidative stress induced by Ang II in AF by targeting NLRP3 and could provide a new potential intervention targets for treatment of AF.
mRNA expression profiling of mitochondrial subunits in subjects with Parkinson’s disease
Authors: Salemi Michele , Cosentino Filomena , Lanza Giuseppe , Cantone Mariagiovanna , Salluzzo Maria Grazia , Giurato Giorgio , Borgione Eugenia , Marchese Giovanna , Santa Paola Sandro , Lanuzza Bartolo , Romano Corrado , Ferri Raffaele
Published: March 2021

Introduction

Parkinson's disease (PD) is a common adult-onset neurodegenerative disorder caused by a progressive loss of dopaminergic neurons due to the accumulation of α-synuclein in the substantia nigra. Mitochondria are known to play a key role in cell respiratory function and bioenergetics. Indeed, mitochondrial dysfunction causes an insufficient energy production required to satisfy the needs of several organs, especially the nervous system. However, the profiling of messenger RNA (mRNA) expression of mitochondrial subunits in PD has not been systematically investigated yet.

Material and methods

We explored the mRNA expression of mitochondrial DNA (mtDNA) encoded respiratory chain (RC) subunits in 43 PD patients and 43 normal controls (NC). Next generation sequencing analysis (NGS) and quantitative real-time Polymerase Chain Reaction (qRT-PCR) assay for the confirmation of the NGS results were used.

Results

All tested mitochondrial RC subunits was significantly over-expressed in subjects with PD compared to NC. In qRT-PCR the mean expression of all mitochondrial subunits had an expression level of at least 7 times compared to NC.

Conclusions

The over-expression of mitochondrial subunits in PD subjects with respect to NC might be secondary to a degeneration-related alteration of the mitochondrial structure and/or dynamics, or to the occurrence of a compensatory mechanism. The study of specific mRNA by peripheral blood mononuclear cells may provide a further diagnostic frame to early detect PD patients.
PEDAGOGIA DO ESPORTE
Authors: Oliveira Mateus Fernandes de , Silva Luis Felipe Nogueira , José Scaglia Alcides
Published: March 2021

Os projetos sociais esportivos têm como advento a promoção da prática de esportes e atividades física que aventem, também, possibilidades de transformações e ressignificações do status quo em ambientes com grandes demandas sociais, econômicas e educacionais. Dessa forma, o estudo buscou diagnosticar, em um projeto social esportivo, desenvolvido no contexto universitário, como são contemplados referenciais que contemplem os aspectos socioeducativos, técnico-táticos e histórico-cultural, chancelados pela disciplina da Pedagogia do Esporte e suas tendências metodológicas emergentes. A investigação foi pautada pela triangulação de dados oriundos de entrevistas com quatro dos membros fundadores, 11 responsáveis legais de alunos e alunas e análise documental do estatuto da instituição pesquisada. Os resultados demonstraram maior contemplação do referencial socioeducativo, realçando a importância de se estabelecer um contexto que viabilizem a participação, formação e a prática de valores sociais por meio do esporte, relativa preocupação com o referencial técnico-tático e lacunas quanto à exploração do referencial histórico-cultural no referido projeto social esportivo. Ressalta-se, assim, o cuidado com a elaboração do projeto político-pedagógico em instituições desta natureza e coerência teórico-prática com a aplicação dos pressupostos didático-metodológicos estabelecidos formalmente.
Las potencialidades del uso del lenguaje positivo en el proceso de enseñanza-aprendizaje
Authors: Salvado Ortega Juan José
Published: March 2021

El empleo de un lenguaje positivo por parte del docente produce unos efectos emocionales que generan en los individuos unos pensamientos y comportamientos óptimos para el aprendizaje. Una comunicación positiva eleva los niveles atencionales, memorísticos, motivacionales y creativos, y, por ende, beneficia las dinámicas académicas, produciendo una mejora en el rendimiento de los alumnos. En el presente artículo se comienza con una revisión bibliográfica de las claves teóricas de la neuroeducación, elemento clave para establecer los mecanismos básicos del aprendizaje cerebral, para, a posteriori, estudiar su implicación y aplicación en el ámbito educativo. Análogamente, se revisan las emociones y el lenguaje, finalizando con una reflexión acerca del papel del profesor y su capacidad potencial a través del lenguaje para mejorar el proceso de enseñanza y aprendizaje.
On a Problem of Wang Concerning the Hamiltonicity of Bipartite Digraphs
Authors: Darbinyan Samvel , Karapetyan Iskandar
Published: March 2021

R. Wang (Discrete Mathematics and Theoretical Computer Science, vol. 19(3), 2017) proposed the following problem. Problem. Let D be a strongly connected balanced bipartite directed graph of order 2a ≥8. Suppose that d(x) ≥ 2a - k, d(y) ≥a + k or d(y) ≥2a - k, d(x) ≥a + k for every pair of vertices {x; y}with a common out-neighbour, where 2 • k • a=2. Is D Hamiltonian? In this paper, we prove that if a digraph D satis¯es the conditions of this problem, then (i) D contains a cycle factor, (ii) for every vertex x ∈ V (D) there exists a vertex y ∈ V (D) such that x and y have a common out-neighbour.
Look Up, Look Down: Articulating Inputs and Outputs of Social Media Social Comparison
Authors: Johnson Benjamin
Published: March 2021

Computer-mediated social comparisons have been identified as a threat to psychological well-being. Because online friends selectively self-present, social comparisons may be biased upward, producing feelings of inadequacy. However, earlier evidence consistently confounded social comparative thoughts with causes or outcomes. A cross-sectional survey (N = 163) tested how traits, motivations, selectivity, and mood management influence computer-mediated downward and upward social comparison, and how comparison influences affect, self-esteem, and peer misperceptions. Results indicated age, social comparison orientation, mood modification, selectivity, and Facebook intensity produced social comparisons. Younger, frequent users made more upward comparisons, while mood modifiers made more downward comparisons. Comparing upward boosted negative affect, harmed self-esteem, and produced pluralistic ignorance. Downward comparisons enhanced self-esteem and reduced pluralistic ignorance about offline friends.
Game Streamers’ Practices on Twitch and Management of Well-Being
Authors: Yu Valerie , Alvarez Katrina , Chen Vivian
Published: March 2021

There has been a noticeable increase in coverage and academic research on the physical and psychological well-being of game streamers. Existing studies have identified challenges and possible negative effects to streamers’ well-being, and they have also explored how streamers utilize the technological features of streaming platforms in their streaming practices. However, scant research has investigated the links between the use of platform features and the management of well-being issues. This study examined how streamers use technological features, the negative well-being issues of streamers, and their coping strategies for these issues. Based on a qualitative content analysis of 23 hours of video interviews with 23 different game streamers discussing well-being issues related to streaming, findings indicate that challenges to well-being arise from prioritizing different outcomes in their streaming practices, and it is game streamers’ resilience and self-aware platform feature use that enables them to face these challenges.
Response and Clinical Outcome of Critically Ill Children with Guillain Barre Syndrome admitted to PICU of Children’s Hospital Lahore
Authors: Jamil Anila , Rashid Nighat , MUHAMMAD SARWAR  , FAREEHA KAUSAR  , GHAZALA SHAFFQAT  , UMER WAQAR AZEEM
Published: March 2021

Objective: To analyze patients with Guillain Barre Syndrome (GBS) requiring intensive care unit (ICU) admission, their course, response to treatment and outcome.

Methods: A retrospective study conducted at ICU of The Children’s Hospital Lahore in 194 children with diagnosis of GBS from June 2018 to May 2020. Demographic profile, clinical features, treatment, duration of mechanical ventilation, length of ICU stay and outcome was noted.  

Results:

Mean age of children was 5.95 ± 3.1 years with male predominance 136 (70 %). Major proportion were in range of 1-5 years 93(47.9%). Mean duration of ICU stay was 21.3±34.4 days. Out of 194 patients 125(64%) received IVIGs while 112 (57.7%) required mechanical ventilation because of rapidly progressive weakness within 24 hours of admission and those who remained on mechanical ventilation for longer period showed AMSAN (Acute motor sensory axonal neuropathy) type of GBS ( p value <0.001). Tracheostomy was performed in 22.7% of patients who were difficult to wean off from ventilator. Among nerve conduction studies AIDP (Acute inflammatory demyelinating polyneuropathy) was predominant 48% associated with p value <0.001 in those who showed complete recovery, followed by AMSAN 24%, AMAN ( Acute motor axonal neuropathy) 13.4% and miscellaneous 13.9 %. Regarding outcome complete recovery was seen in 28%, minimal residual disability in 70% and 1.5% remained ventilator dependent.

Conclusion:

Patients of severe GBS often require prolong respiratory support and ICU care. The indicators of poor outcome are rapidly progressive course, severe weakness and axonal neuropathy leading to longer duration on mechanical ventilation.

KEYWORDS: 

Guillain Barre Syndrome, Outcome, intensive care unit (ICU)
Stigmatizing attitudes toward people living with HIV/AIDS (PLWHA) among primary health care providers in Kinta District, Perak
Authors: Chan Yuen Ching , Mawardi Maliza , Ismail Daud Adibah Hanim
Published: March 2021

Background: Stigmatizing attitudes expressed by health care providers prevent some members of at-risk populations from accessing human immunodeficiency virus (HIV) screening and care. This attitude contributes to the continuity of the infection dissemination within our community, which gives an impact on the healthcare service and the curtailment of the global HIV/acquired immunodeficiency syndrome (AIDS) pandemic.
Objective: This study was conducted to identify stigmatizing attitudes toward people living with HIV/AIDS (PLWHA) and their determinants among primary health care providers in Kinta District, Perak.
Methodology: A cross-sectional study was conducted in 36 primary care clinics in Kinta District, Perak. Using stratified random sampling, 365 primary health care providers were recruited into the study. A validated self-administered questionnaire was used to obtain sociodemographic data as well as information on the healthcare experiences of healthcare providers, their knowledge of HIV/AIDS, and attitudes toward PLWHA. Determinants were identified using multiple linear regression.
Results: More than half of the respondents (54.1%) had never provided care to HIV/AIDS patients. A minority (29.9%) had received training on HIV/AIDS. This study shows that doctors (Coef.= -9.50, 95% CI: -18.93, -0.07, p= 0.048), respondents with HIV-positive relatives, (Coef.= -5.61, 95% CI: -10.57, -0.65, p= 0.027), those who had provided care to HIV/AIDS patients (Coef.= -2.38, 95% CI: -4.31, -0.45, p= 0.016), and those with a higher knowledge score on HIV/AIDS (Coef.= -0.86, 95% CI: -1.59, -0.13, p= 0.021) were less likely to show stigmatizing attitudes toward PLWHA.
Conclusion: The issue of stigmatizing attitudes toward PLWHA among primary health care providers needs to be addressed. This study finds that knowledge, profession, experiences with caring for PLWHA, gender, and having HIV-positive relatives are significant predictors of stigmatizing attitudes toward PLWHA among primary health care providers in Kinta District, Perak. Interventional programs to improve knowledge and awareness, as well as decrease stigma toward PLWHA, should be implemented among all health care providers, especially those who have no opportunity to provide direct care.
Therapy of coronavirus infection
Authors: Akaeva Tatiana , Mkhitaryan Karen , Vasilkovskaya Olesya
Published: March 2021

Background: The computer apparatus for electro-acupuncture diagnostics and medicated testing "IMEDIS-EXPERT" made in Russia was used for the purposes of this work to detect SARS-CoV-2 (COVID-19) or to prove its absence, and to select homoeopathic preparations, nosodes, and their relevant doses. The methods of the system-nosological approach (SNA) were used for the therapy of patients, which included recording and appliance of relevant control signals (C.S.) of homoeopathic preparations, both native and informational (electronic) copies. Aims: 1. Develop an algorithm to select preparations from the group of nosodes and homoeopathy to prevent the development of SARS-CoV-2 (COVID-19); 2. Evaluate the possibility of preventing treatment and therapy of coronavirus infection employing an "electronic vaccine" produced employing coronavirus C.S. Methodology: The electronic preventing "immunization" was made for patients as the preventing treatment of COVID-19, which was an adaptation to coronavirus C.S. conducted in accordance with a special algorithm. The three-block scheme of SNA therapy was used for the therapy of ill patients, which was composed of three preparations, which were used sequentially: 1. Control signal of coronavirus targeted on a patient's CMH; 2. Cerebral response (C.R.) with a patient's cumulative impact of: C.S. of coronavirus and the sum of target organs (blood-forming system, lymphatic systems, lungs, bronchus, gastrointestinal system) and test-indicators of immune regulation targeted on the second CMH marker amplification; 3. Drainages in the form of homeopathic preparations were used (after the impact of two previous preparations), which were: Arsenicum, Arsenicum iod, Carbo vegetabilis, Spongia, Drosera, Naya, Rhus Toxicodendron, and Ferrum met. The preparations were selected to compensate the third impact of CMH. Results: At present, 175 people have asked for help due to COVID-19, an electronic preventing vaccine ("immunization") made for 112 people on the SNA algorithm. According to the diagnostic testing results made for 63 ill patients and who asked for treatment: 47 people tested coronavirus infection, 16 people tested ARVI, and 12 people tested pneumonia caused by a virus. The coincidence of VRT tests (vegetative resonance tests) and PCR was found ranged from 68 to 75%. 4 people got ill by coronavirus among those who got preventing immunization (112 people) by "the electronic sensibilization method" (that was proved by VRT and PCR tests). The illness had the light form among 2 of them, and two people had moderate severity of illness without hospital admission. Conclusion: An algorithm is developed, which allows to select C.S. of therapeutic nosodes and homoeopathic preparations to prevent the development of SARS-CoV-2. The efficiency of applying the electronic immunization method according to the algorithms of SNA using coronavirus C.S. is 95%.
Homeopathy and the COVID-19 pandemic: quasi-experimental observational study
Authors: Holandino Carla , Oliveira Adriana Passos , Vilhena Edgard Costa , Sanches Twoany Rebecca Pedroza , Bolognani Fábio de Almeida , Torres Eliane Turano Monteiro de Castro , Gouveia Célia Maria , Campos Vânia Emerich Bucco , Paiva Juliana Patrão , Homsani Fortune , Freitas Francisco José , Rocha Leandro Machado
Published: March 2021

Background: the number of cases of Covid-19 reached more than 11 million people in Brazil, but mostly in Caxias city (Rio de Janeiro) high death rates are very worrysome. In this scenario, homeopathy therapy, along with sanitary and therapeutic measures, should be recommended by health authorities. Aims: to evaluate the use of homeopathic complex (Bryonia alba, China officinalis and Metallum album 30cH), concerning the severity of the illness, during the coronavirus pandemic. Methodology: the complex was administrated at multiple families from Caxias, with (FW) and without (FWO) symptoms similar to COVID-19’s, therefore qualifying the project as a quasi-experimental longitudinal observational cohort study (applied in 51 families or 128 people). With this, the influence of homeopathic intervention in sick (FW) and health (FWO) groups was estimated. All volunteers used three drops of the medicine, once a day, per 60 days. The medicine was prepared accordingly to the Brazilian Homeopathic Pharmacopoeia1. The follow-up was carried out within seven days, which resulted in a total of 8 weeks, since the first interview. The data was organized and statistically analyzed with a 5% significance level, for categorical variables, by Fisher Exact test, in Excel sheet and SPSS 17.0 platform. The ethical committee approved this project under the code: CAAE 31601020.3.0000.5243. Results and Discussion: the preliminary results showed the absence of deaths in both groups (FW and FWO), without any statistically significant difference related to the severity of illness. Most of the families (98.03%) were thrilled to contribute in this particular homeopathic research and reported to have had general health symptoms’ improvements (84.31%). Despite the previous comorbidities presented in 52.9% of the families and considering that Covid-19 infected 0.020% of them, only 0.098% looked for medical assistance and none needed hospitalization. Conclusion: no differences between previous sick and health groups were detected after homeopathy intervention.
Homeopathy in the treatment of COVID-19
Authors: Holandino Carla , Kokornaczyk Maria Olga
Published: March 2021

An Extraordinary GIRI Meeting took place on the 26 and 27 of November 2020. Due to the current situation, it was held on the ZOOM platform. It regarded the clinical and basic research on COVID-19 and the coronavirus exclusively. The meeting was organized in partnership with the Federal University of Rio de Janeiro (UFRJ) and the International Research Group on Very Low Dosis and High Dilution Effects (GIRI) as a pre-event to the V International Homeopathy Workshop of UFRJ, planned for 2-4 December 2021.

During a pandemic, when there is a general lack of workers, equipment, and medicines, any kind of treatment capable of maintaining or improving people’s health should be considered by all medical facilities. Therefore, the GIRI meeting aimed to collect, discuss, and disseminate knowledge and medical experience gathered by homeopathy researchers and doctors around the world regarding the possibility of treating COVID-19 with homeopathy. The meeting lasted two days and was visited by a large number of participants from Brazil, India, Russia, Belgium, Hong Kong, Switzerland, and England, gathering so researchers, professionals, and many students from different fields of expertise, e.g. pharmacology, medicine, biology, physics, veterinary, chemistry. 

In total, 11 abstracts were approved by a Scientific Committee and presented in a 30-60 min oral contribution. The meeting was interactive, offering space for questions, answers, and for many discussions concerning the potential of homeopathy in the context of COVID-19. The conference provided the possibility to better understand the different homeopathic approaches in the treatment of COVID-19, such as the use of nosodes (prepared from virus particles), that showed a promising immunomodulatory and prophylactic potential. Further, the preliminary analysis of the Clificol COVID-19 support project was presented, revealing a vast international panorama concerning the use of homeopathy in different countries. There were other contributions regarding the use of homeopathy in adults and children for the treatment of COVID-19.

To disseminate even further the findings presented at the Extraordinary GIRI Meeting 2020 related to the role of homeopathy in the COVID-19 pandemic, we are launching this special issue of the International Journal of High Dilution Research (IJHDR).
Intensified modulation of aerosol pollution in China by El Niño with short duration
Authors: Zeng Liangying , Yang Yang , Wang Hailong , Wang Jing , Li Jing , Ren Lili , Li Huimin , Zhou Yang , Wang Pinya , Liao Hong
Published: March 2021

Abstract. El Niño-Southern Oscillation (ENSO), a phenomenon of periodic changes in sea surface temperature in the equatorial central eastern Pacific Ocean, is the strongest signal of interannual variability in the climate system with a quasi-period of 2–7 years. El Niño events have been shown to have important influences on meteorological conditions in China. In this study, the impacts of El Niño with different durations on aerosol concentrations and haze days during December-January-February (DJF) in China are quantitatively examined using the state-of-the-science Energy Exascale Earth System Model version 1 (E3SMv1). We find that PM2.5 concentrations are increased by 1–2 µg m−3 in the northeastern and southern China and decreased by up to 2.4 µg m−3 in central-eastern China during El Niño events relative to the climatological means. Compared to long duration (LD) El Niño events, El Niño with short duration (SD) but strong intensity causes northerly wind anomalies over central-eastern China, which is favorable for aerosol dispersion over this region. Moreover, the anomalous southeasterly winds weaken the wintertime prevailing northwesterly in northeastern China and facilitate aerosol transport from South and Southeast Asia, enhancing aerosol increase in northeastern China during SD El Niño events relative to LD El Niño events. In addition, the modulation on haze days by SD El Niño events is 2–3 times more than that by LD El Niño events in China. The aerosol variations during El Niño events are mainly controlled by anomalous aerosol accumulation/dispersion and transport due to changes in atmospheric circulation, while El Niño-induced precipitation change has little effect. The occurrence frequency of SD El Niño events has been increasing significantly in recent decades, especially after 1940s, suggesting that El Niño with short duration have exerted increasingly intense modulation on aerosol pollution in China over the past few decades.