The role of the gastrointestinal tract in the processes of intoxication and detoxiﬁcation of the body
Authors: Pilat T. L. , Kuzmina L. P. , Kolyaskina M. M. , Bezrukavnikova L. M. 
Published: November 2020

This review presents literature data on the role of the gastric tract in the processes of intoxication and detoxiﬁcation of endoand exobiotics. The factors that promote the absorption and metabolism of toxic products in the gastrointestinal tract are described. The causes of intoxication and the mechanisms of two-phase detoxiﬁcation with the participation of phase I enzymes of the biotransformation of xenobiotics in the intestine, in particular cytochrome P-450 isoenzymes, are described in detail. The predominance of the cytochrome P-450 isoenzyme CYP3A4 in the intestine was shown, and among the enzymes of phase II of biotransformation in the intestinal wall, the most important are UDP-glucuronyltransferase and sulfotransferase. The data on the ways of correction of intoxication with the use of a detoxiﬁcation complex of dietary nutrition are presented. Clinical studies have shown that a specialized program provides antioxidant protection and the work of enzymes of the I and II stages of the metabolism of toxins, a decrease in the absorption and excretion of metabolic products, can signiﬁcantly reduce the intoxication of the body, which is extremely necessary during the treatment and rehabilitation of diseases of the gastrointestinal tract and other organs and systems. rehabilitation of the body. It was found that the use of products of detox nutritional program LEOVIT DETOX led to a signiﬁcant decrease in the concentration of urea and creatinine, which indicates an accelerated elimination of toxins and metabolic products formed in the body. A decrease in the concentration in the blood of the main enzymes characterizing the detoxiﬁcation activity of the liver ALT, AST, GGT was also established.

The aim of the study was to evaluate the detoxiﬁcation eﬀectiveness of the preventive nutrition Program and individual detoxiﬁcation products LEOVIT DETOX, designed to aﬀect all stages of Exo — and endobiotic metabolism.

Materials and methods. Detoxiﬁcation nutrition LEOVIT DETOX includes: specialized food product of dietary preventive nutrition “Complex nutrition program DETOX”, detoxifying jelly and bars — specialized food products of dietary preventive nutrition for detoxiﬁcation of the body. The DETOX nutrition program is designed for 15 days and contains 30 products. The dynamics of biochemical parameters of liver and kidney function disorders (AST, ALT, GGT, urea, creatinine), blood lipid spectrum (by total cholesterol), fasting blood glucose level, and products of lipid peroxidation in blood serum were measured.

Results. The use of specialized food products of dietary prophylactic nutrition “, a Comprehensive nutrition program DETOX” leads to a signiﬁcant decrease in the concentration of urea and creatinine, AST, ALT, GGT, cholesterol, glucose, diene conjugate, ketodienes of CARBONYLS and increased total oxidative activity of blood serum were examined.

Conclusion. The use of a specialized food product of dietary preventive nutrition “Complex nutrition program DETOX” provides eﬀective detoxiﬁcation of the body in diseases of the gastro-intestinal system.