bluuebunny/crossref_metadata_2025 huggingface dataset:
Tenascin-X Deficiency Causing Classical-Like Ehlers-Danlos Syndrome Type 1 in Humans is a Significant Risk Factor of Gastrointestinal and Tracheal Ruptures
Authors: van Gurp Jonneke E. , Lechner Rosan L. , Micha Dimitra , Maugeri Alessandra , Dulfer Eelco , van Dijk Fleur S. , Keszthelyi Daniel , Malfatti Edoardo , Kubo Akiharu , Voermans Nicol C. , Demirdas Serwet
Published: January 2025

INTRODUCTION:

Classical-like Ehlers-Danlos syndrome type 1 (clEDS1) is a very rare form of Ehlers-Danlos syndrome caused by tenascin-X deficiency, with only 56 individuals reported in medical literature. Tenascin-X is an extracellular matrix protein needed for collagen stability. Previous publications propose that individuals with clEDS1 might be at risk of gastrointestinal (GI) tract perforations and/or tracheal ruptures. The aim of this study was to characterize complications resulting from perforations of the GI tract and/or tracheal rupture in an international case series of individuals with clEDS1 due to disease-related tissue fragility.

METHODS:

This case series includes individuals with confirmed clEDS1 and GI perforations and/or tracheal ruptures from participating centers. Researchers who previously reported such individuals were contacted for additional information. A retrospective assessment of clinical features was performed.

RESULTS:

Fifteen individuals were included. Ten had spontaneous GI perforations, 7 of whom had multiple GI perforations. Almost all had severe diverticulosis. Three individuals experienced iatrogenic tracheal ruptures.

DISCUSSION:

Severe GI complications, such as perforation, and tracheal rupture were observed in a substantial number of individuals with clEDS1. As these features seem significantly more common in clEDS1 than in the average population, we advise vigilance during intubation and GI endoscopic interventions of individuals with clEDS1. Routine referrals to clinical geneticists are recommended for patients with symptoms indicative of clEDS1, especially with unexplained GI perforations and connective tissue symptoms. Our findings offer valuable insights for the clinical management of clEDS1 and underscore the importance of specialized care, providing a foundation for improved clinical guidelines and preventive strategies.
Settlement of piles with negative skin friction: design approaches according to part 3 of Eurocode 7
Authors: Zemanová Alena , Anderle Vojtěch , Masopust Jan
Published: January 2025

Piles offer an effective solution for supporting structures in challenging ground conditions. However, ground settlement around deep foundations can induce negative skin friction, adding complexity to the geotechnical analysis and requiring careful consideration in both the pile settlement evaluation and structural integrity design. The article discusses the general recommendations provided by the informative annex of the revised Eurocode 7 version for designing piles subjected to negative skin friction. Using the Fellenius unified pile design concept, we provide a practical design framework for piles subjected to negative skin friction that extends the load-settlement curve methods proposed by Masopust, representing the standard pile design approaches in the Czech Republic. For examples presented, the introduced practical approach, also suitable for manual calculations, is in very good agreement with a refined calculation providing a nonlinear load-settlement curve.
“BEKAS LEWU”: POLITICAL BROKER IN THE MANDUING TAHETA VILLAGE ELECTION, CENTRAL KALIMANTAN
Authors: Haridison Anyualatha
Published: January 2025

Bakas Lewu is a group of elders in the Dayak Ngaju language of Central Kalimantan. Previous studies have been more oriented towards mapping brokers in mobilizing material resources to influence voters. The purpose of this article is to explore the role of Bakas Lewu as political brokers, especially how they work, involving culture and social power, which has been discussed to a limited extent. This study was conducted qualitatively and the main data source came from interviews with key informants who knew about the village head election (Pilkades) cases in Manduing Taheta, then analyzed in depth and interactively. This study shows that Bakas Lewu as political brokers play an important role in mobilizing political support based on social relations, kinship, and local Dayak culture by relying on interpersonal communication, narrative control, and social networks to build community trust and loyalty. This phenomenon emphasizes that political power in the village is more influenced by personal and social relationships than material transactions. This study challenges the dominant approach that sees political brokers in Indonesia as transactional actors, by highlighting the importance of local social and cultural dynamics. These findings indicate the diversity of political brokerage practices and suggest more research on how social relations, such as kinship and loyalty, play a role in mobilizing political support, opening up new perspectives in the study of local politics in Indonesia.
CONTESTATIONS BETWEEN MINIMARKET RETAIL AND LOCAL GROCERY STORES IN ACEH, INDONESIA
Authors: Aulia Faizul , Nazaruddin M , Alwi Alwi
Published: January 2025

This article examines the competition between minimarket retailers and local grocery stores from a sociological perspective. It explores two main patterns of daily shopping habits, which highlight a complex competition for consumer attention. The author aims to demonstrate that this contestation is linked to social change and the business strategies employed by each type of business. The study adopts a descriptive qualitative approach, conducted in Lhokseumawe City, Aceh Province, Indonesia. Data were gathered through observation, in-depth interviews, and literature review, and analyzed descriptively by reducing, verifying, and interpreting to identify key themes and insights. The findings show that the competition between these two shopping patterns is driven by changes in consumer behavior. Minimarkets succeed by offering convenience and more structured services, while local grocery stores remain competitive by providing services rooted in cultural values and fostering close community ties.
Trauma dalam Film Ketika Berhenti di Sini: Eksplorasi Sumber, Respons, dan Strategi Koping (Kajian Psikologi Sastra)
Authors: Jayanti Sekar Tri , Purnomo Mulyo Hadi , Fadilah Yuniardi
Published: January 2025

Film Ketika Berhenti di Sini mengangkat isu trauma, khususnya gangguan stres pasca-trauma (PTSD) setelah kehilangan orang terdekat. Penelitian ini bertujuan menganalisis representasi trauma dalam film tersebut, termasuk sumber trauma, respons yang muncul, dan strategi koping yang digunakan. Pendekatan deskriptif kualitatif dengan teori Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-V) digunakan untuk menganalisis karakter Anandita Semesta yang mengalami trauma akibat kematian ayah dan kekasihnya. Strategi koping menurut Lazarus dan Folkman digunakan untuk memahami penyelesaian trauma. Hasil penelitian menunjukkan gejala PTSD pada Dita, antara lain: 1) mengulang memori traumatis, 2) menghindari benda dan orang yang mengingatkan trauma, 3) perubahan perilaku, dan 4) penurunan semangat hidup. Strategi koping Dita melibatkan dukungan sosial emosional, interpretasi positif, dan penerimaan terhadap keadaannya. Penelitian ini memberikan kontribusi dalam memahami representasi trauma dalam film sebagai refleksi dinamika psikologis dan upaya pemulihan dalam kehidupan sehari-hari.Kata Kunci: Psikologi Sastra, Trauma, PTSD, Ketika Berhenti di Sini, Strategi Koping.
A Survey of Emerging Techniques for Large Networks of Virtual Local Area Networks (VLANs) with Benefits and Limitations
Authors:   Department of Information Technology, Shaik Ajas
Published: January 2025

The numerous benefits of wireless communication have led to its meteoric rise in popularity as a network type, yet
there have been numerous obstacles to enhancing its performance. An alternative method that allows a network
administrator to construct a logical network out of a physical network is VLAN, which stands for Virtual Local Area
Network. Thus, VLANs are fundamental technology for enhancing network performance, capacity and security.
VLANs are a means of breaking large networks into smaller broadcast domains, managing broadcast traffic,
controlling congestion, and providing increased levels of security. This paper explores the emerging techniques in
managing and optimising VLANs within large-scale network environments. VLANs are essential for improving
network performance, security, and scalability by the logical segmentation of networks into smaller, isolated
broadcast domains. This survey also outlines trends in future VLAN technologies such as Software Defined
Networking (SDN), VXLAN, and Big Data and Analytics. Also, the paper covers the uses, advantages, and
disadvantages of VLANs, including enhanced security, scalability, and economy, though admitting to issues of VLAN
configuration difficulty and security threats. In the paper, the authors discussed the future trends including the
integration of multi-cloud, network slicing coupled with 5G, and integration of blockchain for VLAN security.
Czeski sufiks feminatywny -(k)yně i jego polski odpowiednik -ini/-yni. Najnowsze tendencje
Authors: Osowski Błażej
Published: January 2025

Czeski sufiks -(k)yně i polski -ini/-yni mają wspólne pochodzenie oraz funkcję (tworzą formacje żeńskie). Warto zatem przyjrzeć się, jak te formanty funkcjonują we współczesnych językach. W tym celu poddano analizie materiał ze źródeł internetowych i leksykograficznych rejestrujących najnowsze słownictwo. Zebrany materiał analizowano pod kątem pochodności słowotwórczej, regularności semantycznej, kwalifikacji stylistycznej oraz przynależności do grup znaczeniowych.
Já na to dlabu!
Authors: Hrdlička Milan
Published: January 2025

Článek přibližuje vybrané, hojně užívané případy v každodenní komunikaci, v nichž mluvčí z různých důvodů (nevhodnost vyjádření, společenské tabu, přílišná expresivita výrazu aj.) nevolí přímé pojmenování dotyčné skutečnosti. Nahrazuje jej s ohledem na ostatní účastníky komunikace mimo jiné vyjádřením eufemistickým (zemřel – odešel; není již mezi námi aj.), nebo různými způsoby (zejména lexikální) substituce (Já na to kašlu / dlabu / peču aj.; Já se z toho posměju; Ty kráso!), deformací pejorativního vyjádření (To mě sejří; Ty vado!), popř. nedořečením (Já se na to vyto…; On se z toho snad poto…) či vynecháním (elipsou) příslušného výrazu (Já ti jednu…).
Wissenstransfer umgekehrt
Authors: Neumer Werner
Published: January 2025

Beim Reverse Mentoring lernen erfahrene Führungskräfte von jüngeren Nachwuchskräften. Es ist eine wichtige Maßnahme zur Begleitung des demografischen und digitalen Wandels und bietet den Teilnehmenden die Gelegenheit, die Gedankenwelt der anderen Generation besser zu verstehen. Der stattfindende Wissenstransfer unterstützt die digitale Transformation und fachbereichs- und hierarchieübergreifendes Netzwerken sorgt für eine offene, attraktive Unternehmenskultur. Dieser Beitrag beschreibt, wie das Konzept in der Deutschen Bundesbank gelebt wird.
Von der Theorie in die Praxis: Wie Wissensgraphen und Sprachmodelle schon heute helfen, die wissenschaftlichen Fragen von morgen zu beantworten
Authors: Karras Oliver
Published: January 2025

Während die digitale Transformation in vielen Lebensbereichen bereits weit fortgeschritten ist, hat die Wissenschaft das volle Potenzial der Digitalisierung bisher nicht ausgeschöpft. Es besteht ein dringender Bedarf, diese voranzutreiben. Für diesen Zweck ist es erforderlich, über die traditionelle, dokumentenbasierte Darstellung von Daten und Wissen hinauszugehen, um sowohl dem Menschen als auch der Maschine die effiziente Nutzung dieser Informationen zur Beantwortung wissenschaftlicher Fragen zu ermöglichen. In diesem Kontext sind Wissensgraphen und Sprachmodelle vielversprechende Technologien. Der vorliegende Artikel betrachtet theoretisch und anhand von Praxisbeispielen, wie Wissensgraphen und Sprachmodelle jeweils einzeln als auch kombiniert zur Beantwortung wissenschaftlicher Fragen beitragen. Wissensgraphen bieten eine strukturierte und vernetzte Darstellung von Daten und Wissen, die eine Kontextualisierung und umfassende Analyse der Informationen ermöglichen. Sprachmodelle hingegen erleichtern die Interaktion mit großen allgemeinen Wissensbeständen durch natürliche Sprache. Der größte Mehrwert bei der Beantwortung wissenschaftlicher Fragen lässt sich aber durch die Kombination beider Technologien erreichen. Die Synergien, die durch die Kombination von Wissensgraphen und Sprachmodellen entstehen, vereinen die Stärken beider Ansätze und ermöglichen eine präzisere und umfassende Beantwortung wissenschaftlicher Fragen. Zukünftige Forschung muss sich darauf konzentrieren, diese Kombination weiter zu optimieren und neue Anwendungsmöglichkeiten zu erschließen, um das volle Potenzial beider Technologien auszuschöpfen.
Ventral Pallidal GABAergic Neurons Drive Consumption in Male, But Not Female, Rats
Authors: Scott Alexandra , Paulson Anika , Prill Collin , Kermoade Klaiten , Newell Bailey , Eckenwiler Elizabeth A. , Lemos Julia C. , Richard Jocelyn M.
Published: January 2025

Food intake is controlled by multiple converging signals: hormonal signals that provide information about energy homeostasis and hedonic and motivational aspects of food and food cues that can drive nonhomeostatic or “hedonic” feeding. The ventral pallidum (VP) is a brain region implicated in the hedonic and motivational impact of food and food cues, as well as consumption of rewards. Disinhibition of VP neurons has been shown to generate intense hyperphagia, or overconsumption. While VP GABA neurons have been implicated in cue-elicited reward-seeking and motivation, the role of these neurons in the hyperphagia resulting from VP activation remains unclear. Here, we used designer receptors exclusively activated by designer drugs to activate VP GABA neurons in nonrestricted male and female rats during chow and sucrose consumption. We found that activation of VP GABA neurons increases consumption of chow and sucrose in male rats, but not female rats. Together, these findings suggest that activation of VP GABA neurons can stimulate consumption of routine or highly palatable rewards selectively in male rats.
Neuroimaging Model of Visceral Manipulation in an Awake Rat
Authors: Cramer Samuel R. , Han Xu , Chan Dennis C. Y. , Neuberger Thomas , Zhang Nanyin
Published: January 2025

Reciprocal neuronal connections exist between the internal organs of the body and the nervous system. These projections to and from the viscera play an essential role in maintaining and fine-tuning organ responses in order to sustain homeostasis and allostasis. Functional maps of brain regions participating in this bidirectional communication have been previously studied in awake humans and anesthetized rodents. To further refine the mechanistic understanding of visceral influence on brain states, however, new paradigms that allow for more invasive, and ultimately more informative, measurements and perturbations must be explored. Furthermore, such paradigms should prioritize human translatability. In the current paper, we address these issues by demonstrating the feasibility of nonanesthetized animal imaging during visceral manipulation. More specifically, we used a barostat interfaced with an implanted gastric balloon to cyclically induce distension of a nonanesthetized male rat's stomach during simultaneous blood oxygenation level-dependent (BOLD) functional magnetic resonance imaging. General linear modeling and spatial independent component analysis revealed several regions with BOLD activation temporally coincident with the gastric distension stimulus. The ON–OFF (20–0 mmHg) barostat balloon pressure cycle resulted in widespread BOLD activation of the inferior colliculus, cerebellum, ventral midbrain, and a variety of hippocampal structures. These results suggest that neuroimaging models of gastric manipulation in the nonanesthetized rat are achievable and provide an avenue for more comprehensive studies involving the integration of other neuroscience techniques like electrophysiology.
Fast seed germination of the halophyte Suaeda physophora across a wide range of environmental conditions
Authors: Cao Yi , Xing Zeming , Lu Juanjuan , Wang Lei
Published: January 2025

Suaeda physophora, a succulent-leaf euhalophytic subshrub, is known for its unique adaptation to saline environ­ments. This study aimed to evaluate the germination performance of S. physophora seeds under various environmental conditions. The germination of 24-hour-imbibed S. physophora seeds reached 100% within 24 hours at 10/25°C with 12 hours light / 12 hours dark or continuous dark. Even at 5/15°C, the germination could still reach 55% within 24 hours. At a PEG concentration of 20%, the germination was also 60%. Under 200 mmol L-1 NaCl, the germination reached 67% within 24 hours. Germination velocity was affected by temperature, drought and salinity, with the fastest germination velocity observed at 10/25°C without PEG-simulated drought or salinity stress. These findings highlight very fast germination of S. physophora seeds across diverse environmental conditions, making it suitable for ecological research and application.
Reforming the Indonesian Bureaucracy through State Civil Apparatus Reform, Could It be Optimized with Technology?
Authors: Amancik Amancik , Barus Sonia Ivana , Saifulloh Putra Perdana Ahmad , Nggilu Novendri M. , Nur Asrul Ibrahim
Published: January 2025

Bureaucracy, from a societal perspective, is often perceived as complex, slow, and inefficient. Despite these criticisms, bureaucracy remains a fundamental component of governance and plays a crucial role in societal functioning. As such, bureaucratic reform has been a prominent focus of policy discussions for several decades. A technology-driven government system, coupled with a bottom-up approach, has the potential to enhance efficiency, transparency, and accountability in public administration. However, in practice, such reforms have been largely confined to central government institutions and select agencies. This study aims to explore the integration of technology within the bureaucratic system in Indonesia, with a focus on its comprehensive implementation across government structures. Employing a normative research methodology, the study emphasizes the need for the government to take proactive steps in developing a skilled workforce in information technology. The authors also recommend strategically mapping positions that can integrate technological expertise throughout government departments. Furthermore, the study proposes a comprehensive examination of the potential for replacing executive positions with artificial intelligence (AI) to streamline and simplify bureaucratic processes.  In addition to technological advancements, bureaucratic reform must be accompanied by legal reform, particularly in the areas of data security and the protection of personal information. This includes redefining bureaucratic and personal data categories to ensure robust safeguards. The Personal Data Protection Law should play a pivotal role in integrating these data types and ensuring their protection. Moreover, the Telecommunications Act and the Personal Data Protection Act should foster collaboration between the government and technology companies to develop effective security solutions. Lastly, strengthening the Ombudsman as a public service oversight institution is essential to ensuring transparency and accountability in the implementation of bureaucratic and technological reforms.
Indonesia's Land Bank Authority: Aligning with Agrarian Law or Facilitating Land Grabbing?
Authors: Alimuddin Nur Hidayani , Ayu Widowati Dyah , Eka Mayasari Riezka , Febrisari Rizki , Jusafri
Published: January 2025

This research critically examines Indonesia's land bank regulations, introduced under the Job Creation Law to boost investment, but which risk promoting land grabbing, particularly affecting farming and indigenous communities. The study's novelty lies in its focus on assessing the compatibility of land bank policies with Indonesia's agrarian legal framework through the lens of legal utilitarianism. By employing normative research methods, including theoretical and regulatory analysis, the study identifies significant legal flaws in both the legislative process and the content of the regulations. These issues undermine the principles of agrarian justice, particularly in ensuring equitable land ownership rights. This research offers urgent recommendations to policymakers, advocating for the protection of vulnerable communities from the adverse effects of land bank policies.
Constitutional Transition in a Democratic State: A Critical View of the Omnibus Law Establishing Employment Copyright Law
Authors: Rahman Arif , Zaini Ahmad , Hajani Hajani , Haerudin Rendi , Jambunanda Ahmad Jamaludin
Published: January 2025

The debate regarding Omnibus Law as the main means for structuring legal regulations in Indonesia attracted a lot of public attention when the Omnibus Law method, which was previously little known in Indonesia as a country that adheres to the Continental European legal system, was used in the preparation of draft laws (RUU). How does the constitutional transition to the establishment of an omnibus law on copyright work in a democratic country? How do we review the constitutionality of the implementation of the Omnibus Law and the copyright mechanism in the formation of statutory regulations? This research uses the concept of normative descriptive research, or what can be called normative juridical research. With this method, law is interpreted as what is written in legislation (law in a book), or law is interpreted as a legal rule, which is a standard for appropriate behavior. The Omnibus Law method practiced in the common law system is interpreted as a (new) law that regulates various kinds of regulations to simplify the various laws that are still in force. Constitutionally, the legal position of the omnibus law concept has not been regulated in the legal system or in the laws and regulations in Indonesia. Law No. 11 of 2020 concerning Job Creation, which was formed using the Omnibus method, is considered to be constitutionally contradictory because it does not have clear objectives and formulation, both in terms of the standard of formation, the systematics of its creation, and the process of changing its substance.
Revitalizing Customary Law: Reforming Buffalo Farming Practices (Jalangan) in Menaming Village for Sustainable Governance
Authors: Ismi Hayatul , Hasanah Ulfia , Nofrizal Nofrizal , Wook Izawati
Published: January 2025

The buffalo farming system in Menaming Village is deeply rooted in traditional practices, combining grazing and caging methods that reflect the community's cultural values and environmental stewardship. These practices, designed to minimize the exploitation of natural resources, position Rokan Hulu as a region with significant potential to support both local livelihoods and national economic development. The research emphasizes the role of customary law, recognized in Indonesia's Constitution, in upholding these traditional practices and fostering sustainable livestock management. This study highlights the integration of local wisdom into buffalo farming, including practices such as converting manure into organic fertilizer, utilizing organic materials for fuel, adopting pesticide-free animal feed, and implementing rotational grazing systems. These strategies reduce environmental degradation, maintain ecological balance, and enhance livestock health and productivity. Moreover, they generate economic benefits, create employment opportunities, improve farmers’ incomes, and strengthen social cohesion through community-based activities and mutual cooperation. The novelty of this research lies in its demonstration of how customary law can be revitalized and integrated into contemporary governance frameworks to address modern challenges in sustainable agriculture and environmental conservation. This study contributes to the discourse on law reform by proposing that customary law be formally recognized and adapted within Indonesia's legal system as a dynamic tool for promoting sustainable development, empowering local communities, and preserving cultural heritage.
Evaluation of Integrated Business Licensing System in Indonesia Using HOT-fit Model
Authors: Masbudi Handika , Husain Husain , Lusa Sofian , Sensuse Dana Indra , Indriasari Sofianti , Putro Prasetyo Adi Wibowo
Published: January 2025

Purpose: In an increasingly interconnected global economy, there is a growing recognition among governments of the importance of fostering an environment for businesses to thrive. Indonesia has introduced an integrated business licensing system that centralizes and automates the licensing and permitting processes, simplifying the journey for entrepreneurs, business owners, and government agencies. To multiply the benefits and effectiveness of the system, the government must assess the system to establish a firm basis for its ongoing advancement and enhancement.
Methods: The evaluation of integrated business licensing system was conducted using the HOT-fit framework with the perspective of government agencies. Their involvement is crucial for effective licensing and supervision processes. Data was gathered through questionnaires and analyzed using the PLS-SEM method.
Result: The findings revealed that system quality and service quality significantly influenced user satisfaction, whereas information quality, user satisfaction, organizational structure, and organizational environment positively impacted system usage. The results also showed that system usage and user satisfaction influenced net benefit. These results can be used to improve the system to match the government agencies’ expectations.
Novelty: The novelty of this study lies in its research object which is an integrated system. This research provides insights for targeted improvements in technological, organizational, and human aspects of integrated system implementation.
Improving neuroendocrine tumor treatments with mathematical modeling: lessons from other endocrine cancers
Authors: Metzcar John , Guenter Rachael , Wang Yafei , Baker Kimberly M , Lines Kate E
Published: January 2025

Neuroendocrine tumors (NETs) occur sporadically or as part of rare endocrine tumor syndromes (RETSs) such as multiple endocrine neoplasia 1 and von Hippel–Lindau syndromes. Due to their relative rarity and lack of model systems, NETs and RETSs are difficult to study, hindering advancements in therapeutic development. Causal or mechanistic mathematical modeling is widely deployed in disease areas such as breast and prostate cancers, aiding the understanding of observations and streamlining in vitro and in vivo modeling efforts. Mathematical modeling, while not yet widely utilized in NET research, offers an opportunity to accelerate NET research and therapy development. To illustrate this, we highlight examples of how mathematical modeling associated with more common endocrine cancers has been successfully used in the preclinical, translational and clinical settings. We also provide a scope of the limited work that has been done in NETs and map how these techniques can be utilized in NET research to address specific outstanding challenges in the field. Finally, we include practical details such as hardware and data requirements, present advantages and disadvantages of various mathematical modeling approaches and discuss challenges of using mathematical modeling. Through a cross-disciplinary approach, we believe that many currently difficult problems can be made more tractable by applying mathematical modeling and that the field of rare diseases in endocrine oncology is well poised to take advantage of these techniques.
Dicer inhibition delays wound closure by increasing Suz12 levels and regulating ITGAV levels in keratinocytes
Authors: Bhattacharya Sushant , Hazra Shruti , Datta Malabika
Published: January 2025

Delayed wound closure is a significant hallmark associated with diabetes. A previous study from our laboratory identified decreased levels of Dicer and miRNAs together with altered levels of wound-healing genes in the wounded tissues of diabetic rats. Comprehensive regulators of these wound-healing genes mapped onto the PRC2 (polycomb repressive complex 2) complex. Here, we show that Dicer inhibition increases the transcript levels of core components of the PRC2 complex, namely Suz12 (suppressor of zeste 12) and Ezh2 (enhancer of zeste 2), and of Mtf2 (metal response element-binding transcription factor 2), its additional subunit, and elevates H3K27me3 levels in HaCaT cells. Such patterns of increase were also observed in the wounded tissues of diabetic rats as compared to those of normal rats. In a scratch assay in HaCaT cells, while Dicer inhibition significantly prevented wound closure, this was rescued by Suz12 siRNA but not by Ezh2 inhibition, suggesting that Suz12 mediates the effects of Dicer siRNA in these cells. In addition, as compared to scramble-transfected cells, Dicer siRNA decreased the levels of integrin alpha V (Itgav), which is extensively implicated in the process of wound healing, and this effect was rescued in the presence of Suz12 siRNA. Itgav harbours potential histone methylation marks across the gene length, and Dicer inhibition, by increasing PRC2-mediated H3K27 methylation on Itgav, possibly decreases its transcription that subsequently impairs wound closure. These data put forth novel aspects of delayed wound closure as seen during diabetes and might be a potential target for therapeutic intervention.
A virtuális valóság használatának lehetőségei gyermekek perioperatív ellátásában
Authors: Trinh Sarolta Haiyen , Kis-Tamás Melinda , Pápai János , Kálmán Attila , Cserép Melinda , Jermendy Ágnes , Hauser Balázs
Published: January 2025

Évente világszerte több millió gyermeket altatnak különböző sebészeti vagy
diagnosztikus beavatkozások miatt szükségessé váló általános érzéstelenítés
kapcsán. Magyarországon ez a szám évente körülbelül 20–30 ezer gyermek, akiket
gyermeksebészeti központokban kezelnek, további 5–10 ezer gyermek ellátása pedig
felnőtt gégészeti osztályokon történik. A gyermekek kezelése különösen nagy
kihívást jelent, mivel kognitív és érzelmi fejlődési szintjük nehezíti az
előttük álló beavatkozások megértését, és bizonytalanná teszi a beavatkozással
járó stresszes állapot feldolgozását. Az altatások előtti szorongás gyakran
fokozott posztoperatív fájdalomhoz, zavartsághoz és hosszabb kórházi
tartózkodáshoz vezethet, valamint nemkívánatos magatartásbeli változások is
kialakulhatnak. A perioperatív szorongás és fájdalom kezelésére különböző
módszerek (premedikációként adott szorongáscsökkentők, szülői jelenlét
biztosítása az anesztézia indukciójakor, posztoperatív fájdalomcsillapítók)
állnak rendelkezésre. Bár a figyelemelterelő módszerek (zene, mesefilmek)
hatékonynak bizonyultak, jelenleg továbbra is a farmakológiai kezelést tekintjük
alapvető módszernek. Az újabb, alternatív megoldások (pszichoedukáció, virtuális
valóság) alkalmazása még nem vált a mindennapi gyakorlat részévé. A virtuális
valóság egy új, innovatív eszköz, amely immerzív, háromdimenziós, audiovizuális
élményt nyújt, elvonva a gyermekek figyelmét a kellemetlen tapasztalatokról. A
virtuális valóság alkalmazása gyermekgyógyászati környezetben különösen
ígéretes, mivel a gyermekek figyelme könnyen leköthető virtuális játékokkal, ami
csökkenti a beavatkozások okozta szorongást és fájdalmat. A jelenlegi közlemény
a virtuális valóság gyermekgyógyászati vonatkozásait, annak procedurális és
perioperatív környezetben való használatának lehetőségeit mutatja be irodalmi
adatok alapján annak kapcsán, hogy a módszerrel történő saját tapasztalatszerzés
elindult a Semmelweis Egyetem Gyermekgyógyászati Klinikáján. Orv Hetil. 2025;
166(2): 50–59.
Midwives as advocates
Authors: Verskin Sara
Published: January 2025

Throughout the medieval world, women’s bodily statuses could have religio-legal consequences, and for that reason female midwives were sometimes called in as expert witnesses in Islamic legal proceedings to examine and testify about women’s bodies. Midwives in such roles appear, at first glance, to be the eyes and instruments of male authorities. Drawing on fatwas from North Africa and Islamic Spain, however, this article argues that the role of midwives was sometimes more complex. Each of the three cases presented here addresses a different concern about a woman’s body. In the first, a question arises as to whether a widow is pregnant. In the second, whether an orphan girl is sufficiently physically developed to marry. In the third, the question is whether and when a kidnapped and assaulted girl lost her virginity. In each case, the midwives repeatedly changed their testimonies. This was not a symptom of either dysfunction or unreliability; rather; it was a product of the midwives’ roles as agents of women in precarious positions, women whose calculations about what constituted their best interests were constantly shifting. The testimonies of midwives in these cases served less as a patriarchal means of weaponizing women’s own bodies against them, and more as tools for converting women’s personal distresses and hopes into actionable legal petitions. The midwives worked to secure the religio-legal status that would confer the greatest benefit on the women in need, and that would provide a framework for the community to meet those needs. Thus, it behooves historians to view these midwives not merely as instruments of prosecutorial and censorious men, but rather as advocates for women.
Differential Object Marking in DGS (German Sign Language): A prominence-based account of the use of PAM based on naturalistic data
Authors: de Souza Santos Thiago , Dietrich Antonia , Steinbach Peggy , Perniss Pamela
Published: January 2025

This paper examines the nature of object marking in DGS (German Sign Language), providing an account of the behavior of the sign glossed as PAM, previously analyzed as an agreement auxiliary (person agreement marker) and more recently as a differential object marker (Bross 2020). We investigate the influence of animacy and definiteness (object individuation) and the affectedness of the object as properties that have been claimed to be relevant for differential object marking, in general, and for DGS, in particular. We provide an account of object-marking based on the notion of linguistic prominence, specifically on how the use of PAM in DGS may be interpreted as providing additional information (marking) that brings the object into the center of attention. We suggest that the use of PAM is triggered through object prominence in three ways: being highly individuated (animate, definite); being a stimulus/causer rather than a patient; not being (very) affected by the verbal action. In addition, we find that an association with negative intent by the subject as well as the selectional constraints on verbs occurring with PAM are captured very well for DGS by the account proposed by Meir (2003) for ISL (Israeli Sign Language), a sign language historically related to DGS.
"NOT WHO BUT WHAT: WHAT IS SHE?" Disembodied Quests for Utopia and Retrotopia from Mkrtich Armen’s Yerevan (1931) to Thomas Pynchon’s V. (1963)
Authors: Leupold David
Published: January 2025

The paper engages two works of the 20th century in a cross-temporal dialogue: the novel Yerevan (1931) written 14 years after the October Revolution by the Soviet-Armenian writer Mkrtich Armen and the novel V. (1963), written three decade and one world war later by the US-American writer Thomas Pynchon. At first glance, the two works do not make for a likely pair – on the one hand, a milestone in modern North American literary history and, on the other hand, a work from the former Soviet South, written in Armenian, banned upon publication and almost forgotten until its post-Soviet republication in 2016. The essay reads the novels for the themes of utopia, retrotopia and modernities in contest. In spite of their apparent difference in context and history of origin, it demonstrates that the plots of both Armen's and Pynchon's novel are structured around bafflingly similar disembodied quests that haunt their respective main protagonists. Set in light of the Cold War and the anti-colonial struggle, Pynchon's V. stands as a placeholder for a form of Western modernity that brought humanity to the brink of self-extinction. Armen's Yerevan, on the other hand, refers to a distinctly different, revolutionary horizon of expectation characteristic for the 1920s and early 1930s, when hopes for emancipating, socialist form of modernity were not yet obscured by the dread of Stalinism. Read together (and against each other), the paper argues that the tragic-utopian quest for Asmar in the Soviet-Armenian 1930s and the ironic-(anti-)anti-utopian quest for V. in the US-American 1960s construe a complex dialectical image of human progress, its inherent possibilities and pitfalls.
Prerequisites and Consequences of Territorial Servitisation in Russian Regions
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Pushkarev A. A. , Ruzhanskaya L. S. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin, Tyazhelnikov V. D. ,   Ural Federal University named after the first President of Russia B. N. Yeltsin
Published: January 2025

The need to find new sources of economic growth in industrial and old industrial areas determines the importance of research into the relationship between knowledge-intensive business services and industrial development in regions. This paper aims to explore how Russian regions participate in territorial servitisation, focusing on the growth of knowledge-intensive business service activities. The study also seeks to determine whether this participation helps boost productivity in manufacturing companies by implementing a servitisation strategy—specifically, by adding services to their products. The proposed analytical framework addresses the gap between research on the effects of servitisation strategies and the potential for enhancing a region’s industrial capacity through the knowledge-intensive business services sector. This study is the first to use Russian data to explore the concept of territorial servitisation, thereby contributing to the advancement of this topic in economic literature through its novel methodology. The research employs a three-step CDM model with fixed effects for panel data. Based on the econometric analysis of manufacturing companies across 56 Russian regions, the findings indicate that the integration of knowledge-intensive business services into the regional economy is positively influenced by market size and an increase in the number of manufacturing firms. Moreover, the anticipated growth rate of knowledge-intensive services is positively associated with the servitisation of manufacturing firms in the region. In addition, the study shows a positive correlation between the projected share of employment in servitised firms and productivity in manufacturing firms, as measured by output per employee. The results of this study can inform policy-making in regional economic and industrial development. However, the study faces limitations related to the challenges of accurately capturing the actual use of service classifications (OKVEDs) by Russian manufacturing companies.
El rol del método inductivo como vínculo entre las teorías educativas y las prácticas de aula
Authors: López-Morocho Luis Rodolfo , Jaramillo Baquerizo Christian Paul
Published: January 2025

This study addresses the issue of the relationship between theories and pedagogical models,focusing on their connection with educational research and classroom practice. In this context, the main objective is to analyze the role of the inductive method in the relationship between theories and pedagogical models from classroom praxis, using meta-research and reflective critique based on Grounded Theory. Thus, the definitions of theories and pedagogical models, the historical role of the inductive method in educational research, the relationship between inductive reasoning,the main theories and pedagogical models, and the practical implications of these approaches in teaching and learning are explored. The results reveal that the inductive method is essential for formulating hypotheses, theories, and models from empirical observations, providing a solid foundation for educational research. Additionally, it has significantly influenced the development of various pedagogical models, facilitating the integration of theory and practice, which is vital foreffective teaching. In conclusion, the study highlights the ongoing relevance of the inductive method in educational research and its potential to improve pedagogical practices, especially with the advancement of technology, which offers new opportunities to enhance data collection and analysis.
Aportes del método inductivo a la enseñanza de la ética militar
Authors: Fernández-Osorio Andrés Eduardo , Miron Marina , Whetham David
Published: January 2025

The ethical training of military forces is essential for democracy as it guides respect for human rights, observance of the laws of war, and protection of institutional legitimacy. For this reason, military ethics has become a crucial tool to guide the behavior of the military in complexenvironments and ensure responsible decision-making. In this context, this article evaluates theimpact of the Basic Concepts in Military Ethics course and its inductive approach on the attitudesand behaviors of Colombian military personnel. Using a quantitative methodology, a study was conducted with 230 course participants at the General Rafael Reyes Prieto Higher War School in Colombia to measure attitudes about military ethics, rules of engagement, and operational effectiveness. The main results identified that the course positively impacted the participants’attitudes about the importance of military ethics, its contribution to unit cohesion, and its influence on responsible decision-making. It is concluded that training in military ethics, through innovative methods such as inductive, prepares the military to face the challenges of today’s world and responsibly fulfill their mission.
Metodologías inductivas en la educación, apoyadas por la integración de la tecnología
Authors: Veytia Bucheli María Guadalupe , Collazo Fuentes Magda , Rivera Alejo Francisco
Published: January 2025

This paper analyzes the translation and validation of the instrument developed by Floresand Adlaon (2022) to apply the inductive method with the SAMR model in Spanish-speakingeducational contexts. The justification for the topic lies in the need to adapt effective pedagogicaltools to the Spanish language to facilitate their use in teaching and learning with technology.The main objectives were to translate the instrument and, through the judgment of experts inthe educational and technological fields, to carry out its semantic validation. The methodologyincluded the translation of the instrument Extent of ICT Integration in Science Based on SAMRModel into Spanish, followed by its validation. The 11 experts evaluated the relevance and clarityof the items using a Likert scale from 0 to 5. The content validity was calculated with the AikenV methodology, obtaining a coefficient of 0.8163, which indicates a good validity index, theCronbach Alpha value was 0.9682. The results showed that, although most of the items were wellrated, some required reformulation to improve their clarity, relevance and comprehension in theSpanish translation. The instrument proved to be adequate for evaluating the degree of integrationof ICT in education, facilitating its application in Spanish-speaking contexts and promoting theadoption of inductive methodologies supported by educational technologies.
Aportes de la escuela de Frankfurt y Edgar Morin para fomentar el pensar dialéctico y complejo en la educación
Authors: López-Pérez Sheila
Published: January 2025

The aim of this text is to present an educational proposal that challenges the way adolescentsin school think, and, consequently, how they relate to uncertainty, change, and otherness. To this end, the text starts from the formulation of a "method" –a key term in this work– based on thephilosophies of the Frankfurt School and Edgar Morin, which can address the multidimensionalityand multireferentiality of reality: dialectical and complex thinking. It is believed that only sucha way of thinking, one that turns the individual into a strategist, will produce citizens capable of taking responsibility for their democracies. The connection between education and politicsis clarified, with the first positioned as the foundation and engine of the latter. The educationalproposal for forming complex citizens is then described, which is based on the recovery of aprofound culture capable of deepening adolescents’ thinking and distancing them from simplisticand totalizing discourses. Finally, it is concluded that the only way to avoid new barbarities, such as Auschwitz –both as an extermination camp and, more importantly, as a metaphor for the placeknowledge can lead without an educated thought to guide it– is to promote an education forcomplexity, understanding, and freedom.
Los modelos científicos como herramientas epistémicasabstractas para aprender a razonar
Authors: Bengoetxea Cousillas Juan Bautista
Published: January 2025

The variety of scientific methodologies aimed at obtaining knowledge, generating beliefs,and promoting action is very wide. Both philosophy of science and science education havebeen concerned with critically assessing the virtues of the various scientific methods, especiallythe inductive and deductive ones. However, the emergence of new procedures specific to nonacademicsciences has encouraged the development of new reflective perspectives that can analyzethose virtues. From randomized controlled trials to epidemiological or clinical procedures, thePhilosophy of Science has been concerned with examining the virtues and also the defects of theirpractical set-up. The article assumes that modeling based on empirical evidence is a practice of high interest in linguistics. In order to substantiate this assumption, two philosophical approaches to scientific modeling distinguished by their respective research lines on the notion of representationare compared: the Representational and the Pragmatic. These accounts are then illustrated with abrief case taken from linguistics called language parsing, aimed at examining several particularsamples collected as evidence in early stages of experimental modeling. By way of conclusion, it isemphasized that both philosophical accounts provide analytical elements that are relevant for thekind of scientific reasoning around models and whose scope in science education may be of greatpractical interest.
Kalkınma Planlarındaki Kırsal Yerleşime Yönelik Hedeflerin Uygulanma Düzeyi: Kayseri Yamula Barajı Çevresi Örneği
Authors: Bektaş İbrahim , Ozkose Aysun
Published: January 2025

Kalkınma faaliyetleri kapsamında önemli konulardan biri kırsal kalkınmadır. Bu çalışmada, Türkiye Cumhuriyeti tarafından kırsal kalkınma alanında kırsal yerleşim ve kırsal yapılaşma özelinde gerçekleştirilen faaliyetler konu edinmiştir. Çalışma kapsamında kalkınma planlarında kırsal alanlara yönelik destek kararları, kırsal yerleşim ve yapılaşmalara ilişkin geliştirilen projeler incelenmiştir. Sürdürülebilir kırsal kalkınma gerçekleştirilebilmesi için Kayseri Yamula Barajı kenarındaki kırsal yerleşim bölgeleri özelinde alan çalışması üzerinden kırsal yerleşimlerde bulunması gerekli mekânlar irdelenmiştir. Böylelikle sürdürülebilir kırsal kalkınma için gerekli olan sürdürülebilir kırsal yerleşim alanları oluşturulması amaçlanmıştır. Elde edilen veriler ışığında sürdürülebilir kırsal kalkınma kapsamında yapılması gereken çalışmalar hakkında önerilerde bulunulmuştur. Yapılan çalışmanın diğer çalışmalara katkı sağlaması ümit edilmektedir.