Phytochemical screening, investigation of the antisalmonella, antishigella, and antioxidant properties of the leaves of Rauvolfia vomitoria Afzel.
Authors:   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin, Kpadonou-Kpoviessi Bénédicta ,   Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Faculty of Health Sciences (FSS), Faculty of Sciences and Technics (FAST), 01 BP: 188 Cotonou, Benin, Noudamadjo Amandine ,   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin,   Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Faculty of Health Sciences (FSS), Faculty of Sciences and Technics (FAST), 01 BP: 188 Cotonou, Benin,   Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT) Institute of Medical Research and Medicinal Plants Studies (IMPM), PO. Box 13033, Yaoundé, Cameroon, Goueti Basile ,   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin,   Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Faculty of Health Sciences (FSS), Faculty of Sciences and Technics (FAST), 01 BP: 188 Cotonou, Benin,   Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT) Institute of Medical Research and Medicinal Plants Studies (IMPM), PO. Box 13033, Yaoundé, Cameroon, Atchade Bardieu ,   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin, Toukam Paul Djouonzo ,   Center for Studies on Medicinal Plants and Traditional Medicine (CRPMT) Institute of Medical Research and Medicinal Plants Studies (IMPM), PO. Box 13033, Yaoundé, Cameroon, Gbenou Joachim ,   Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Faculty of Health Sciences (FSS), Faculty of Sciences and Technics (FAST), 01 BP: 188 Cotonou, Benin, Glinma Bienvenu ,   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin, Kpoviessi Salomé ,   Laboratory of Physic and Synthesis Organic Chemistry (LaCOPS), University of Abomey-Calavi (UAC), Faculty of Sciences and Technics (FAST), 01 BP: 4166 Cotonou, Benin,   Laboratory of Pharmacognosy and Essential Oils (LAPHE), University of Abomey-Calavi (UAC), Faculty of Health Sciences (FSS), Faculty of Sciences and Technics (FAST), 01 BP: 188 Cotonou, Benin
Published: June 2024

Rauvolfia vomitoria is a plant acclimatized in Benin - Africa that people use to treat several illnesses such as malaria, cough, typhoid fever, madness, toothache, diabetes, and nausea. The most used organs are leaves, stems, and roots. Thus, the purpose of this work is to contribute to the valorization of R. vomitoria by chemical and biological studies of this plant. Phytochemical analyses of the powder extracts were performed and revealed the presence of alkaloids, tannins, flavonoids, anthocyanins, saponins, terpenes, coumarins, mucilages, reducing compounds, free anthracene derivatives, bound anthracene derivatives (O-glycosides and C-glycosides) with absence of leuco-anthocyanins, quinone derivatives, steroids and cardiotonic glycosids. Evaluation of antisalmonella and antishigella properties of ethanol-water (70:30; V/V) and ethanolic extracts of R. vomitoria leaves showed minimum inhibitory concentrations (MIC) greater than 2000 µg.mL-1 against Salmonella and Shigella strains. The ethanolic extract was the most active by ABTS and FRAP methods and had very good antioxidant activity at scavenging concentration (SC50) equal to 138,62 µg.mL-1 and 185,99 µg.mL-1 respectively