bluuebunny/crossref_metadata_2025 huggingface dataset:
The Use of a Heat Pump in a Ventilation Unit as an Economical and Ecological Source of Heat for the Ventilation System of an Indoor Swimming Pool Facility
Authors: Ratajczak Katarzyna , Szczechowiak Edward
Published: December 2020

Air handling units are usually used to maintain the thermal and humidity parameters in indoor swimming pools that are used for lap swimming and recreation. Their use throughout the year consumes much more energy than, for example, air conditioning in residential or office buildings. Their considerable energy consumption is due to the need for their continuous operation to remove moisture gains from the evaporation of water and to heat the air and cover the heat losses of the pool. It is possible to design ventilation devices in such a way that the operating costs will be reduced, and the environmental impact will be significantly reduced. In this article, six different ventilation units in which different heat sources are used to heat the ventilation air have been evaluated; the selection of which was based on the most commonly used solutions. The results of the analysis are aimed to show which of the available heat sources is the most advantageous in terms of global and operating costs, and in terms of low CO2 emissions. Indicators of both the final and primary energy consumption, as well as the operating and global costs, were determined. The recommended solution that was chosen was the one that had both the lowest cost index (18–20% lower than most ecological sources) and the low primary energy index (8–13% higher than most ecological sources). The results showed that a heat pump in the ventilation unit proved to be the most beneficial solution. Unfortunately, this solution is rarely used due to its high investment costs (20% higher). However, the results have shown that the investment cost of using an advanced air handling unit will be recouped in only two to three years. Also, the global cost for units with a heat pump proved to be the lowest, despite high investment cost.
Effect of Color Coating of Cover Plate on Thermal Behavior of Flat Plate Solar Collector
Authors: Li Chengyi , Huang Qunwu , Wang Yiping
Published: December 2020

An important trend of Building Integrated Solar Thermal (BIST) system is to improve the aesthetic aspect of the solar collector to meet the requirement of architectural style and energy collection. Painting on the glass cover in an appropriate method is a simple and practical way. In this study, a halftone coating was used to print a red brick wall pattern on the glass cover. A series of comparative experiments were carried out to test the effect of the coating on the thermal behavior of the solar collector. In heat collection processes, compared with the solar collector with blank cover plate, the one with coated cover plate has lower absorber plate temperature and higher cover plate temperature. The lower the solar irradiance, the smaller the effect of color coating on the solar collector. Compared with the uncoated surface, the coated surface is more sensitive to solar irradiation. In the same heat collection process, compared with the solar collector coated on the outer surface of the cover plate, the one coated on the inner surface has 0.8 °C higher heat absorber plate temperature and 5% lower top heat loss.
Energies and Its Worldwide Research
Authors: Novas Nuria , Alcayde Alfredo , Robalo Isabel , Manzano-Agugliaro Francisco , Montoya Francisco G.
Published: December 2020

Energy efficiency and management is certainly one of the key drivers of human progress. Thus, the trends in the energy research are a topic of interest for the scientific community. The aim of this study is to highlight global research trends in this field through the analysis of a scientific journal indexed exclusively in the energy and fuels category. For this purpose, a journal has been selected that is in the center of the category considering its impact factor, which is only indexed in this category and of open access, Energies of the publisher MDPI. Therefore, a bibliometric analysis of all the contents of the journal between 2008 and 2020, 13,740 documents published, has been carried out. Analyzing the articles that are linked to each other by their citations, 14 clusters or research topics have been detected: smart grids; climate change–electric energy community; energy storage; bioenergy sources; prediction algorithms applied to power; optimization of the grid link for renewable energy; wind power; sustainability of power systems; hydrocarbon improvements; conversion of thermal/electrical energy; electric motor advancements; marine renewable energy; hydropower and energy storage; and preventive techniques in power transformers. The main keywords found were electric vehicle, renewable energy, microgrid, smart grid, and energy efficiency. In short, energy research remains necessary to meet the future challenge of sustainable energy with high efficiency and the exploration of new renewable resources, all for increasingly sustainable cities.
Considerations on Potentials, Greenhouse Gas, and Energy Performance of Biofuels Based on Forest Residues for Heavy-Duty Road Transport in Sweden
Authors: Soam Shveta , Börjesson Pål
Published: December 2020

This case study investigates the potentials, greenhouse gas (GHG), and energy performance of forest residue biofuels produced by new and emerging production technologies, which are commercially implemented in Sweden for heavy transport. The biofuel options included are ethanol (ED 95), hydro-processed vegetable oil (HVO), and liquefied biogas (LBG) produced from logging residues in forestry and sawdust generated in sawmills. The calculated life cycle GHG emissions, based on the EU Renewable Energy Directive calculation methodology, for all three pathways are in the range of 6–11 g CO2eq./MJ, corresponding to 88–94% GHG emission reductions as compared to fossil fuel. Critical parameters are the enzyme configuration for ethanol, hydrogen supply systems and bio-oil technology for HVO, and gasifier size for LBG. The energy input is ranging from 0.16 to 0.43 MJ/MJ biofuel and the total conversion efficiency from the feedstock to biofuel, including high-value by-products (excluding heat), varies between 61 and 65%. The study concludes that the domestic biofuel potential from estimated accessible logging residues and sawdust is equivalent to 50–100% of the current use of fossil diesel in heavy-duty road transport in Sweden, depending on the biofuel production technology selected and excluding energy by-products. Thus, an expansion of forest-based biofuels is a promising strategy to meet the ambitious climate goals in the transport sector in Sweden.
A Preliminary Techno-Economic Comparison between DC Electrification and Trains with On-Board Energy Storage Systems
Authors: Lamedica Regina , Ruvio Alessandro , Tobia Manuel , Buffarini Guido Guidi , Carones Nicola
Published: December 2020

The paper presents a preliminary technical-economic comparison between a 3 kV DC railway and the use of trains with on-board storage systems. Numerical simulations have been carried out on a real railway line, which presents an electrified section at 3 kV DC and a non-electrified section, currently covered by diesel-powered trains. Different types of ESS have been analyzed, implementing the models in Matlab/Simulink environment. A preparatory economic investigation has been carried out.
The Post-Fire Assembly Processes of Tree Communities Based on Spatial Analysis of a Sierra Nevada Mixed-Conifer Forest
Authors: Tamjidi Jelveh , Lutz James A.
Published: December 2020

Understanding the mechanisms underlying tree spatial arrangements may provide significant insights into the processes in the maintenance of species coexistence. We examined the potential role of habitat heterogeneity, dispersal limitation, negative density dependence, fire history, and unilateral intraspecific and interspecific interactions of adults on juveniles in shaping the spatial patterns of four dominant tree species (Abies concolor, Pinus lambertiana, Calocedrus decurrens, and Quercus kelloggii) after fire in the Yosemite Forest Dynamic Plot, California, USA. We used the univariate pair correlation function and implemented three point pattern processes (homogeneous Poisson process, inhomogeneous Poisson process, and homogeneous Thomas process) to evaluate the potential contributions of habitat filtering and dispersal limitation. We used a bivariate null model to evaluate unilateral intraspecific and interspecific interactions of adults on juveniles. We also used the pairwise correlation function to investigate the spatial patterns of density dependence. To understand the effect of fire, we used the univariate pair correlation function to investigate pattern changes during the six years following fire. We compared spatial pattern changes in both sprouting species (Quercus kelloggii) and seeding species (Abies concolor), and also examined the changes in patterns of large-diameter individuals of Abies concolor, Pinus lambertiana, and Calocedrus decurrens in 2013 (pre-fire), 2016 (two years post-fire), and 2019. Comparing the contributions of the homogeneous Thomas process and the inhomogeneous Poisson process at different spatial scales showed the importance of dispersal limitation and habitat heterogeneity at finer scales (0 m to 5 m) and coarser scales (5 m to 60 m), respectively, which suggests that the joint effects of dispersal limitation and habitat heterogeneity contribute to the spatial patterns of these three dominant tree species. Furthermore, the results showed that the young individuals of Abies concolor and Pinus lambertiana were more commonly found around the conspecific adults. Juvenile regeneration to the 1 cm diameter threshold was highly aggregated following the fire. Large-diameter trees of Abies concolor, Pinus lambertiana, and Calocedrus decurrens generally did not exhibit patterns different from complete spatial randomness (Calocedrus decurrens), or displayed only slight aggregation (Abies concolor and Pinus lambertiana). In addition, Abies concolor and Pinus lambertiana showed positive and negative conspecific density dependence in the immediate post-fire period, respectively.
Blending Emotions and Cross-Modality in Sonic Seasoning: Towards Greater Applicability in the Design of Multisensory Food Experiences
Authors: Reinoso-Carvalho Felipe , Gunn Laura H. , Horst Enrique ter , Spence Charles
Published: December 2020

Sonic seasoning refers to the way in which music can influence multisensory tasting experiences. To date, the majority of the research on sonic seasoning has been conducted in Europe or the USA, typically in a within-participants experimental context. In the present study, we assessed the applicability of sonic seasoning in a large-scale between-participants setting in Asia. A sample of 1611 participants tasted one sample of chocolate while listening to a song that evoked a specific combination of cross-modal and emotional consequences. The results revealed that the music’s emotional character had a more prominent effect than its cross-modally corresponding attributes on the multisensory tasting experience. Participants expressed a higher buying intention for the chocolate and rated it as having a softer texture when listening to mainly positive (as compared to mainly negative) music. The chocolates were rated as having a more intense flavor amongst those participants listening to ‘softer’ as compared to ‘harder’ music. Therefore, the present study demonstrates that music is capable of triggering a combination of specific cross-modal and emotional effects in the multisensory tasting experience of a chocolate.
Effect of Oxidation on Quality of Chiba Tofu Produced by Soy Isolate Protein When Subjected to Storage
Authors: Xu Yue , Wang Zhongjiang , Qi Baokun , Ran Anqi , Guo Zengwang , Jiang Lianzhou
Published: December 2020

Chiba tofu is a new type of vegetarian food prepared with soy protein isolate (SPI). According to factory feedback, the SPI stored in the factory storeroom in summer undergoes reactive oxidation, which changes the structure of SPI and further affects the quality of Chiba tofu. Consequently, the main objective of this study was to prepare Chiba tofu with SPI with different storage periods and evaluate the effect of different degrees of oxidation on structural characteristics of SPI and rheology, texture, microstructure and sensory properties of Chiba tofu. The carbonyl content and turbidity of SPI significantly increased, and the contents of free sulfhydryl (SH) and disulfide bond (S-S) simultaneously decreased with storage time. The oxidation changes the SPI conformation, leading to a transition of α-helix and β-turn to β-sheet and random coil during the storage periods. In the SDS–PAGE analysis, oxidation promoted the SPI molecules crosslinked and aggregated, which affected the quality of Chiba tofu. In short storage periods (0–12 days), SPI was relatively moderately oxidized when the carbonyl content was between 4.14 and 6.87 mmol/g. The storage and loss modulus of Chiba tofu both increased, the network was compact, and the hardness and springiness of Chiba tofu showed an increasing trend. Moreover, in longer storage periods (12–30 days), the SPI was relatively severely oxidized when the carbonyl content was between 7.24 and 9.14 mmol/g, which had an adverse effect on Chiba tofu rheological and texture properties, microstructure, and sensory properties. In sensory evaluation, Chiba tofu stored 12 days had the highest overall quality score than that stored on other days. This study is expected to provide an argument for the better industrial production of Chiba tofu.
Optical Absorption and Scattering Properties at 900–1650 nm and Their Relationships with Soluble Solid Content and Soluble Sugars in Apple Flesh during Storage
Authors: Fang Li , Wei Kangli , Feng Li , Tu Kang , Peng Jing , Wang Jiahong , Pan Leiqing
Published: December 2020

Soluble solid content (SSC) is regarded as the most significant internal quality associated with the taste and maturity in fruits. Evaluating the relationship between the optical properties and soluble sugars facilitates exploration of the mechanism of optical techniques in SSC assessment. In this research, absorption coefficient (μa) and reduced scattering coefficient (μ′s) of Fuji apple during storage were obtained using automatic integrating sphere (AIS) at 905–1650 nm. Relationships between μa, μ′s and SSC, and soluble sugars contents, were investigated. The result showed that SSC, the content of total soluble sugars (TSS), fructose, glucose and sucrose were all decreasing after storage, and the same trend appeared in the change of μa and μ′s. In the whole wavelength range, both μa and μ′s were positively related to SSC and soluble sugars contents. The correlations between μa and SSC, and soluble sugars contents, showed increasing tendencies with increasing wavelengths, while for μ′s, correlations had the opposite trend. The strongest correlations between μa and SSC, and soluble sugars contents, were observed in the correlation of μa with sucrose, with an r of 0.934. Furthermore, a partial least square (PLS) model for sucrose based on μa was built with the coefficient of determination of prediction (Rp2) and the root mean square error of prediction (RMSEP) of 0.851 and 1.047, respectively. The overall results demonstrate that optical properties at the range of 905–1650 nm could be used to evaluate SSC of apples and this may due to the strong correlation between sucrose content and μa.
Food Protein Sterylation: Chemical Reactions between Reactive Amino Acids and Sterol Oxidation Products under Food Processing Conditions
Authors: Kamgang Nzekoue Franks , Henle Thomas , Caprioli Giovanni , Sagratini Gianni , Hellwig Michael
Published: December 2020

Sterols, especially cholesterol and phytosterols, are important components of food lipids. During food processing, such as heating, sterols, like unsaturated fatty acids, can be oxidized. Protein modification by secondary products of lipid peroxidation has recently been demonstrated in food through a process called lipation. Similarly, this study was performed to assess, for the first time, the possibility of reactions between food proteins and sterol oxidation products in conditions relevant for food processing. Therefore, reaction models consisting of oxysterol (cholesterol 5α,6α-epoxide) and reactive amino acids (arginine, lysine, and methionine) were incubated in various conditions of concentration (0–8 mM), time (0–120 min), and temperature (30–180 °C). The identification of lysine adducts through thin-layer chromatography (TLC), high-performance liquid chromatography (HPLC) with a diode array detector (DAD), and electrospray ionization (ESI) mass spectrometry (MS) evidenced a reaction with lysine. Moreover, the HPLC-ESI with tandem mass spectrometry (MS/MS) analyses allowed observation of the compound, whose mass to charge ratio m/z 710.5 and fragmentation patterns corresponded to the reaction product [M + H]+ between cholesterol-5α,6α-epoxide and the ε-amino-group of Nα-benzoylglycyl-l-lysine. Moreover, kinetic studies between Nα-benzoylglycyl-l-lysine as a model for protein-bound lysine and cholesterol 5α,6α-epoxide were performed, showing that the formation of lysine adducts strongly increases with time, temperature, and oxysterol level. This preliminary study suggests that in conditions commonly reached during food processing, sterol oxidation products could react covalently with protein-bound lysine, causing protein modifications.
Strategies to Improve Meat Products’ Quality
Authors: Ursachi Claudiu Ștefan , Perța-Crișan Simona , Munteanu Florentina-Daniela
Published: December 2020

Meat products represent an important component of the human diet, their consumption registering a global increase over the last few years. These foodstuffs constitute a good source of energy and some nutrients, such as essential amino acids, high biological value proteins, minerals like iron, zinc, selenium, manganese and B-complex vitamins, especially vitamin B12. On the other hand, nutritionists have associated high consumption of processed meat with an increased risk of several diseases. Researchers and processed meat producers are involved in finding methods to eliminate nutritional deficiencies and potentially toxic compounds, to obtain healthier products and at the same time with no affecting the sensorial quality and safety of the meat products. The present review aims to summarize the newest trends regarding the most important methods that can be applied to obtain high-quality products. Nutritional enrichment with natural bioactive plant compounds (antioxidants, dietary fibers) or probiotics, reduction of harmful components (salt, nitrate/nitrite, N-nitrosamines) and the use of alternative technologies (high-pressure processing, cold plasma, ultrasounds) are the most used current strategies to accomplish this aim.
Influence of Stabilizing and Encapsulating Polymers on Antioxidant Capacity, Stability, and Kinetic Release of Thyme Essential Oil Nanocapsules
Authors: González-Reza Ricardo M. , Hernández-Sánchez Humberto , Zambrano-Zaragoza Maria L. , Gutiérrez-López Gustavo F. , Del-Real Alicia , Quintanar-Guerrero David , Velasco-Bejarano Benjamín
Published: December 2020

The release kinetics, stability, and antioxidant capacity of thyme essential oil polymeric nanocapsules as a function of encapsulating (poly-ε-caprolactone and ethylcellulose) and stabilizing (polyvinyl alcohol and Pluronic® F-127) polymers were established. Samples were evaluated in terms of particle size, zeta potential, release kinetics, calorimetry, infrared spectra, antioxidant capacity, and diffuse reflectance. The particle size obtained was below 500 nm in all cases, ensuring nanometric size. Zeta potential as a function of the stabilizing polymer. Encapsulation efficiency was higher in the samples that contained ethyl cellulose (around 70%), associated with its affinity for the molecules contained in the essential oil. Differential scanning calorimetry revealed a strong dependence on the encapsulating polymers as a function of the melting temperatures obtained. Infrared spectra confirmed that the polymeric nanocapsules had the typical bands of the aromatic groups of thyme essential oil. The antioxidant capacity evaluated is a function exclusively of the active content in the nucleolus of the nanocapsules. Nanoencapsulation was not a significant factor. Diffuse reflectance revealed high physical stability of the dispersions related directly to the particle size and zeta potential obtained (either by ionic or steric effect). These findings confirm favorable characteristics that allow proposing these systems for potential applications in food processing and preservation.
Antioxidant Activity in Frozen Plant Foods: Effect of Cryoprotectants, Freezing Process and Frozen Storage
Authors: Neri Lilia , Faieta Marco , Di Mattia Carla , Sacchetti Giampiero , Mastrocola Dino , Pittia Paola
Published: December 2020

The antioxidant activity (AOA) of plant foods is recognized as an index of the potential health benefits resulting from their consumption. Due to their high perishability and seasonality, plant foods are largely consumed or used as processed products and freezing is one of the technologies used for the production of high-quality foods. However, cell breakages occurring during freezing and frozen storage can lead to the release of antioxidant compounds and their degradation due to chemical and enzymatic oxidation reactions, and thus, they could present a lower antioxidant activity compared to the corresponding fresh product. In this context, process conditions, freezing pre-treatments and the use of cryoprotectants can limit the extent of freeze-induced damages and preserve the antioxidant activity of plant foods. This review collects and discusses the state-of-the-art knowledge on the single and combined effect of freezing and frozen storage conditions on the antioxidant activity of fruits and vegetables as well as the role of cryoprotectants. Classes of compounds responsible for the antioxidant activity of plant foods and the most common methods used for the evaluation of the antioxidant activity in vitro are also presented. The freezing principles and the effects of ice nucleation and crystallization on fruits, vegetables and their main derivatives (juices, pulps) have been addressed to highlight their impact on the AOA of plant foods. The effect of freezing and frozen storage on the AOA of plant foods resulted dependant on a series of intrinsic factors (e.g., composition and structure), while the role of extrinsic processing-related factors, such as freezing and storage temperatures, is ambiguous. In particular, many conflicting results are reported in the literature with a high variability depending on the method of analysis used for the AOA evaluation and data expression (fresh or dry weight). Other intrinsic raw material properties (e.g., cultivar, ripening degree), post-harvest conditions, as well as defrosting methods that in the majority of the studies are scarcely reported, contribute to the aforementioned discrepancies. Finally, due to the limited number of studies reported in the literature and the high variability in product processing, the effect of cryoprotectants on the AOA of plant foods remains unclear.
Swarm Satellite Magnetic Field Data Analysis Prior to 2019 Mw = 7.1 Ridgecrest (California, USA) Earthquake
Authors: Marchetti Dedalo , De Santis Angelo , Campuzano Saioa A. , Soldani Maurizio , Piscini Alessandro , Sabbagh Dario , Cianchini Gianfranco , Perrone Loredana , Orlando Martina
Published: December 2020

This work presents an analysis of the ESA Swarm satellite magnetic data preceding the Mw = 7.1 California Ridgecrest earthquake that occurred on 6 July 2019. In detail, we show the main results of a procedure that investigates the track-by-track residual of the magnetic field data acquired by the Swarm constellation from 1000 days before the event and inside the Dobrovolsky’s area. To exclude global geomagnetic perturbations, we select the data considering only quiet geomagnetic field time, defined by thresholds on Dst and ap geomagnetic indices, and we repeat the same analysis in two comparison areas at the same geomagnetic latitude of the Ridgecrest earthquake epicentre not affected by significant seismicity and in the same period here investigated. As the main result, we find some increases of the anomalies in the Y (East) component of the magnetic field starting from about 500 days before the earthquake. Comparing such anomalies with those in the validation areas, it seems that the geomagnetic activity over California from 222 to 168 days before the mainshock could be produced by the preparation phase of the seismic event. This anticipation time is compatible with the Rikitake empirical law, recently confirmed from Swarm satellite data. Furthermore, the Swarm Bravo satellite, i.e., that one at highest orbit, passed above the epicentral area 15 min before the earthquake and detected an anomaly mainly in the Y component. These analyses applied to the Ridgecrest earthquake not only intend to better understand the physical processes behind the preparation phase of the medium-large earthquakes in the world, but also demonstrate the usefulness of a satellite constellation to monitor the ionospheric activity and, in the future, to possibly make reliable earthquake forecasting.
Revisiting the Paleo Elbe Valley: Reconstruction of the Holocene, Sedimentary Development on Basis of High-Resolution Grain Size Data and Shallow Seismics
Authors: Papenmeier Svenja , Hass H. Christian
Published: December 2020

The Paleo Elbe Valley is the most prominent subsurface structure in the southern North Sea. During the Weichselian (marine isotope stage (MIS) 2), the valley traversed the exposed sea floor and drained the southern margin of the Scandinavian ice sheet. Today the valley is filled with up to 16 m thick sediments, but the responsible processes and drivers remain unknown. To unravel these processes and describe the valley’s evolution with Holocene transgression, we use shallow seismic data and vertical high-resolution grain-size core data. At the base of the western shore, supralittoral fine sands are overlain by a thin layer of clay dated to 9.8 cal. ka BP. The major sediment package consists of marine silt with internal seismic reflectors inclined in a northeastern direction, indicating a sediment transport from the southwest. The valley infill started when the western shore was flooded around 9.6 cal. ka BP and can be divided into two phases. During the first one (9.6–8.1 cal. ka BP) the sedimentation rate was highly driven by wind and waves. The second phase (8.1–5.0 cal. ka BP) was mainly tidal dominated but shows also storm event deposits in the north. Around 5.0 cal. ka BP the valley was almost filled.
Long-Term Care Preferences and Sexual Orientation: Protocol for a Systematic Review
Authors: Buczak-Stec Elżbieta , König Hans-Helmut , Feddern Lukas , Hajek André
Published: December 2020

Background: With increasing age, the health status of older individuals commonly deteriorates and their care needs greatly increase. Therefore, many individuals are in need for formal or informal long-term care. In order to plan suitable long-term care settings, it is important to know the long-term care preferences of an ageing population (both heterosexuals and sexual minorities). The aim of this study is to systematically review the literature for evidence on preferences regarding long-term care and the potential differences with regard to sexual orientation. Methods and analysis: This study protocol for a systematic review is reported according to the PRISMA-P guidelines. A comprehensive search of published studies will be conducted using PubMed, Web of Science and PsycINFO bibliographic databases. Following predefined inclusion criteria, two authors will screen the titles and abstracts of the studies independently. Afterwards, we will obtain and screen full-text articles of eligible studies using the predefined inclusion criteria. Discrepancies will be resolved by consensus or consultation with a third researcher. Data will be extracted and synthesised. Extracted data will be categorised based on study design, type of long-term care preferences and the group (sexual orientation) which is addressed. The quality of reporting of the studies included will be assessed.
An Ontological Clinical Decision Support System Based on Clinical Guidelines for Diabetes Patients in Sri Lanka
Authors: Madhusanka Sajith , Walisadeera Anusha , Dantanarayana Gilmini , Goonetillake Jeevani , Ginige Athula
Published: December 2020

Health professionals should follow the clinical guidelines to decrease healthcare costs to avoid unnecessary testing and to minimize the variations among healthcare providers. In addition, this will minimize the mistakes in diagnosis and treatment processes. To this end, it is possible to use Clinical Decision Support Systems that implement the clinical guidelines. Clinical guidelines published by international associations are not suitable for developing countries such as Sri Lanka, due to the economic background, lack of resources, and unavailability of some laboratory tests. Hence, a set of clinical guidelines has been formulated based on the various published international professional organizations from a Sri Lankan context. Furthermore, these guidelines are usually presented in non-computer-interpretable narrative text or non-executable flow chart formats. In order to fill this gap, this research study finds a suitable approach to represent/organize the clinical guidelines in a Sri Lankan context that is suitable to be used in a clinical decision support system. To this end, we introduced a novel approach which is an ontological model based on the clinical guidelines. As it is revealed that there are 4 million diabetes patients in Sri Lanka, which is approximately twenty percent of the total population, we used diabetes-related guidelines in this research. Firstly, conceptual models were designed to map the acquired diabetes-related clinical guidelines using Business Process Model and Notation 2.0. Two models were designed in mapping the diagnosis process of Type 1 and Type 2 Diabetes, and Gestational diabetes. Furthermore, several conceptual models were designed to map the treatment plans in guidelines by using flowcharting. These designs were validated by domain experts by using questionnaires. Grüninger and Fox’s method was used to design and evaluate the ontology based on the designed conceptual models. Domain experts’ feedback and several real-life diabetic scenarios were used to validate and evaluate the developed ontology. The evaluation results show that all suggested answers based on the proposed ontological model are accurate and well addressed with respect to the real-world scenarios. A clinical decision support system was implemented based on the ontological knowledge base using the Jena Framework, and this system can be used to access the diabetic information and knowledge in the Sri Lankan context. However, this contribution is not limited to diabetes or a local context, and can be applied to any disease or any context.
An Exercise Training and Healthy Eating Group Program (ATHENA) for Overweight and Obese Women with Urinary Incontinence: An Intervention Description
Authors: Howard Zara , Ross Lynda , Smith Leanne , Baker Nadine , Nucifora Jennifer , Townsend Heidi , Weir Kelly , Roberts Shelley
Published: December 2020

Background: Despite strong evidence for supervised pelvic floor muscle training (PFMT) for women with urinary incontinence (UI), and weight loss and exercise for overweight and obese women with UI, implementation literature on these combined interventions is limited. This paper aimed to describe the rigorous and systematic processes involved in the collaborative development, implementation, refinement and evaluation of a novel, holistic 12 week exercise training and healthy eating group program (ATHENA) for overweight and obese women with UI. Methods/Design: This intervention description paper is part of a larger mixed-methods feasibility study of implementing the ATHENA intervention within a physiotherapy service at a public hospital in Australia. The collaborative intervention design had input from clinicians, researchers and a consumer representative. Results: The intervention involved four evidence-based components—(1) supervised PFMT; (2) general exercise training; (3) pelvic health education; and (4) healthy eating education—delivered face to face over a 12 week period. Supporting resources developed included a Facilitator’s Guide and Participant Workbook. Conclusion: ATHENA is an evidence-based, multifaceted, group-based intervention targeting exercise training and healthy eating for management of UI for overweight and obese women. The structured development process and transparency of intervention content and resources aims to enhance practical application and success in future studies.
Social-Ecological Examination of Non-Consensual Sexting Perpetration among U.S. Adolescents
Authors: Valido Alberto , Espelage Dorothy L. , Hong Jun Sung , Rivas-Koehl Matthew , Robinson Luz E.
Published: December 2020

Adolescent sexting is a serious public health concern and is associated with adverse psychosocial outcomes, including depression, anxiety, low self-esteem, declining academic performance, and health problems. Effective prevention of sexting requires a comprehensive and deep understanding of the multiple contexts whereby sexting is likely to occur. The present study explores individual and contextual risk and protective factors that are associated with sexting behavior among a large sample of adolescents. Participants were high school students in midwestern U.S. (N = 2501; LGB n = 309, 76.4% female; non-LGB n = 2192, 47.4% female) who completed self-report measures of sexting and risk (e.g., pornography exposure, impulsivity) and protective (e.g., social support) factors. Path analysis models were conducted with the sexting outcome for groups of LGB and non-LGB students. Among LGB students, results indicated a significant association between sexting and parental monitoring (b = −0.08, p < 0.01); pornography exposure (b = 0.13, p < 0.05); dating partners (b = 0.01, p < 0.01); bullying perpetration (b = 0.17, p < 0.001); and delinquency (b = 0.13; p < 0.001). Among non-LGB students, significant associations were found between sexting and alcohol/substance use (b = 0.05, p < 0.001); bullying (b = 0.08, p < 0.001); and delinquency (b = 0.06, p < 0.001). Moderation analyses suggest that parental monitoring may have a buffering effect between sexting and several risk factors. Recommendations for practitioners include considering the protective factors of sexting perpetration and encouraging appropriate levels of parental monitoring and the continued importance of bullying and alcohol and drug prevention programming to decrease risk factors of sexting perpetration.
Dental Caries among Refugees in Europe: A Systematic Literature Review
Authors: Bhusari Sneha , Ilechukwu Chiamaka , Elwishahy Abdelrahman , Horstick Olaf , Winkler Volker , Antia Khatia
Published: December 2020

Oral health is one of the most neglected aspects of refugee health. The study aimed to systematically review evidence on prevalence of dental caries and dental care services provided to refugees in Europe. Following PRISMA guidelines, we searched PubMed, Cochrane, WHOLIS, Web of Science, Medline Ovid, and Google Scholar identifying studies on dental caries among refugees in Europe after the 2015 refugee crisis. From 3160 records, fourteen studies were included in the analysis. Eight studies on oral health showed caries prevalence of between 50% and 100%, while it ranged from 3% to 65% in six general health studies. Caries prevalence was proportional to age and inversely associated with education, whereas gender and country of origin showed no significant association. Nowhere is oral health part of general health assessment on arrival and is complaint based. Primary focus on resettlement, language, cultural, and economic barriers emerged as explanatory models for limited access. Our study identified a high prevalence of caries and limited access to dental health services as main challenges. Integrating oral health check-ups may contribute in shifting towards preventive oral care. Further research is urgently needed to better understand the dental needs of refugees in Europe.
Long-Term Benefits of Tailored Exercise in Severe Sarcoidosis: A Case Report
Authors: Herrera-Olivares Alba M. , García-Manso Juan M. , Rodríguez-Gómez Irene , Ara Ignacio , Lucia Alejandro , Santalla Alfredo
Published: December 2020

Background: We studied the effects of a supervised, structured exercise program in a severe sarcoidosis patient. Methods: After being clinically stable for two years, a 52-year-old woman (stage IV, American Thoracic Society) who originally had irreversible lung fibrosis, pulmonary arterial hypertension (PAH), mild mitral insufficiency, and atrial dilatation, and was candidate for lung transplant, performed a combined high-intensity interval, high load resistance, and inspiratory muscle training for 4.5 years, and was tested (cardiopulmonary exercise testing and dual X-ray absorptiometry) every six months. Results: Cardiorespiratory fitness (CRF) and maximal pulmonary ventilation increased by 44% and 60%, respectively. Ventilatory efficiency also improved (decrease in the ventilatory equivalent for oxygen by 32% and 14% at the ventilatory threshold and respiratory compensation point, respectively). She improved New York Heart Association (NYHA) class (from III to II), and cardiac alterations as well as PAH reversed so that she was not in need of lung transplantation anymore. Likewise, she suffered no more episodes of hemoptysis. Bone health was overall maintained despite the post-menopausal status and the corticoid treatment. Conclusions: A long-term combined exercise intervention safely contributed—at least partly—to improve CRF and NYHA class in a patient with severe sarcoidosis, suggesting a potential coadjuvant effect to attenuate clinical manifestations.
Drink Driving as the Commonest Drug Driving—A Perspective from Europe
Authors: Allsop Richard
Published: December 2020

People mixing driving motor vehicles with consuming alcohol increases deaths and injuries on the roads, as was established irrefutably in the mid-1960s. This commentary discusses how society across Europe has responded since then to this burden by managing drink driving in the interests of road safety. The principal response has been to set, communicate and enforce limits on the level of alcohol in the blood above which it is illegal to drive and to deal in various ways with drivers found to be exceeding the limits. Achieving reduction in drink-related road deaths has benefitted public health, though the aim to change behaviour of drinking drivers has been a challenge to the profession. Other achievements have included changes in public attitude to drink driving, and reduction in reoffending by convicted offenders through rehabilitation courses and use of the alcohol interlock, which prevents starting of a vehicle by a driver who has drunk too much. There is scope for improved recording of road deaths identified as drink-related, greater understanding of effectiveness in enforcement of the legal limit and improved availability of the alcohol interlock. Relevance of experience with drink driving to management of other drug driving and prospects for building on the achievements so far are discussed.
The Identification of Diabetes Mellitus Subtypes Applying Cluster Analysis Techniques: A Systematic Review
Authors: Sarría-Santamera Antonio , Orazumbekova Binur , Maulenkul Tilektes , Gaipov Abduzhappar , Atageldiyeva Kuralay
Published: December 2020

Diabetes Mellitus is a chronic and lifelong disease that incurs a huge burden to healthcare systems. Its prevalence is on the rise worldwide. Diabetes is more complex than the classification of Type 1 and 2 may suggest. The purpose of this systematic review was to identify the research studies that tried to find new sub-groups of diabetes patients by using unsupervised learning methods. The search was conducted on Pubmed and Medline databases by two independent researchers. All time publications on cluster analysis of diabetes patients were selected and analysed. Among fourteen studies that were included in the final review, five studies found five identical clusters: Severe Autoimmune Diabetes; Severe Insulin-Deficient Diabetes; Severe Insulin-Resistant Diabetes; Mild Obesity-Related Diabetes; and Mild Age-Related Diabetes. In addition, two studies found the same clusters, except Severe Autoimmune Diabetes cluster. Results of other studies differed from one to another and were less consistent. Cluster analysis enabled finding non-classic heterogeneity in diabetes, but there is still a necessity to explore and validate the capabilities of cluster analysis in more diverse and wider populations.
Spadin Modulates Astrocytic Passive Conductance via Inhibition of TWIK-1/TREK-1 Heterodimeric Channels
Authors: Bae Yeonju , Choi Jae Hyouk , Ryoo Kanghyun , Kim Ajung , Kwon Osung , Jung Hyun-Gug , Hwang Eun Mi , Park Jae-Yong
Published: December 2020

Astrocytes, the most abundant cell type in the brain, are non-excitable cells and play critical roles in brain function. Mature astrocytes typically exhibit a linear current–voltage relationship termed passive conductance, which is believed to enable astrocytes to maintain potassium homeostasis in the brain. We previously demonstrated that TWIK-1/TREK-1 heterodimeric channels mainly contribute to astrocytic passive conductance. However, the molecular identity of astrocytic passive conductance is still controversial and needs to be elucidated. Here, we report that spadin, an inhibitor of TREK-1, can dramatically reduce astrocytic passive conductance in brain slices. A series of gene silencing experiments demonstrated that spadin-sensitive currents are mediated by TWIK-1/TREK-1 heterodimeric channels in cultured astrocytes and hippocampal astrocytes from brain slices. Our study clearly showed that TWIK-1/TREK-1-heterodimeric channels can act as the main molecular machinery of astrocytic passive conductance, and suggested that spadin can be used as a specific inhibitor to control astrocytic passive conductance.
Immunodetection of Pectic Epitopes, Arabinogalactan Proteins, and Extensins in Mucilage Cells from the Ovules of Pilosella officinarum Vaill. and Taraxacum officinale Agg. (Asteraceae)
Authors: Płachno Bartosz J. , Kapusta Małgorzata , Świątek Piotr , Stolarczyk Piotr , Kocki Janusz
Published: December 2020

The main aim of this study was to compare the cytological difference between ovular mucilage cells in two Asteraceae species—Pilosella officinarum and Taraxacum officinale—in order to determine whether pectic epitopes, arabinogalactan proteins, or extensins are present. The immunocytochemical technique was used. Both the Taracacum and Pilosella genera have been used recently as models for understanding the mechanisms of apomixis. Knowledge of the presence of signal molecules (pectic epitopes, arabinogalactan proteins, and extensins) can help better understand the developmental processes in these plants during seed growth. The results showed that in Pilosella officinarum, there was an accumulation of pectins in the mucilage, including both weakly and highly esterified pectins, which was in contrast to the mucilage of Taraxacum officinale, which had low amounts of these pectins. However, Taraxacum protoplasts of mucilage cells were rich in weakly methyl-esterified pectins. While the mucilage contained arabinogalactan proteins in both of the studied species, the types of arabinogalactan proteins were different. In both of the studied species, extensins were recorded in the transmitting tissues. Arabinogalactan proteins as well as weakly and highly esterified pectins and extensins occurred in close proximity to calcium oxalate crystals in both Taraxacum and Pilosella cells.
Nonalcoholic Fatty Liver Disease and Non-Alcoholic Steatohepatitis: Current Issues and Future Perspectives in Preclinical and Clinical Research
Authors: Berardo Clarissa , Di Pasqua Laura Giuseppina , Cagna Marta , Richelmi Plinio , Vairetti Mariapia , Ferrigno Andrea
Published: December 2020

Nonalcoholic fatty liver disease (NAFLD) is a continuum of liver abnormalities often starting as simple steatosis and to potentially progress into nonalcoholic steatohepatitis (NASH), fibrosis, cirrhosis and hepatocellular carcinoma. Because of its increasing prevalence, NAFLD is becoming a major public health concern, in parallel with a worldwide increase in the recurrence rate of diabetes and metabolic syndrome. It has been estimated that NASH cirrhosis may surpass viral hepatitis C and become the leading indication for liver transplantation in the next decades. The broadening of the knowledge about NASH pathogenesis and progression is of pivotal importance for the discovery of new targeted and more effective therapies; aim of this review is to offer a comprehensive and updated overview on NAFLD and NASH pathogenesis, the most recommended treatments, drugs under development and new drug targets. The most relevant in vitro and in vivo models of NAFLD and NASH will be also reviewed, as well as the main molecular pathways involved in NAFLD and NASH development.
Transient Receptor Potential Vanilloid 6 (TRPV6) Proteins Control the Extracellular Matrix Structure of the Placental Labyrinth
Authors: Winter Manuel , Weissgerber Petra , Klein Karolin , Lux Femke , Yildiz Daniela , Wissenbach Ulrich , Philipp Stephan E. , Meyer Markus R. , Flockerzi Veit , Fecher-Trost Claudia
Published: December 2020

Calcium-selective transient receptor potential Vanilloid 6 (TRPV6) channels are expressed in fetal labyrinth trophoblasts as part of the feto–maternal barrier, necessary for sufficient calcium supply, embryo growth, and bone development during pregnancy. Recently, we have shown a less- compact labyrinth morphology of Trpv6-deficient placentae, and reduced Ca2+ uptake of primary trophoblasts upon functional deletion of TRPV6. Trpv6-/- trophoblasts show a distinct calcium-dependent phenotype. Deep proteomic profiling of wt and Trpv6-/- primary trophoblasts using label-free quantitative mass spectrometry leads to the identification of 2778 proteins. Among those, a group of proteases, including high-temperature requirement A serine peptidase 1 (HTRA1) and different granzymes are more abundantly expressed in Trpv6-/- trophoblast lysates, whereas the extracellular matrix protein fibronectin and the fibronectin-domain-containing protein 3A (FND3A) were markedly reduced. Trpv6-/-placenta lysates contain a higher intrinsic proteolytic activity increasing fibronectin degradation. Our results show that the extracellular matrix formation of the placental labyrinth depends on TRPV6; its deletion in trophoblasts correlates with the increased expression of proteases controlling the extracellular matrix in the labyrinth during pregnancy.