bluuebunny/crossref_metadata_2025 huggingface dataset:
Does the volume of physical exercise influence sleep quality in patients with fibromyalgia?
Authors: De Souza L.C. , Torres Vilarino G. , Andrade A.
Published: October 2024

Objective. To investigate the association between the volume of exercise and the quality of sleep in patients with fibromyalgia.
Methods. This is a cross-sectional study carried out from 2010 to 2019 in patients over 18 years old from the research project at a university in Brazil. Instruments related to sociodemographic and clinical characteristics, physical exercise, and the Pittsburgh Sleep Quality Index (PSQI) were applied. Participants were classified as inactive, insufficiently active, or active. In the statistical analysis, the Kruskal-Wallis and Mann-Whitney U tests were used. Binary logistic and multinomial regression were also performed.
Results. The majority of participants were physically inactive and had poor sleep quality; 68.3% with poor sleep quality were inactive. In the analysis of the difference between the three groups, sleep latency (time it takes to fall asleep) (p=0.00) and total PSQI (p=0.04) were significantly different. When the analysis was performed between active and inactive individuals, significant differences were found in sleep latency (p=0.02), daytime dysfunction (difficulties in performing daytime tasks due to poor sleep quality) (p=0.02), and the total PSQI (p=0.02). Binary logistic regression with crude analysis showed that inactive participants are 4.3 times more likely to have poor sleep quality when compared to active participants (odds ratio = 4.311; 95% confidence interval 1.338-13.888; p=0.014). Multinomial regression analysis showed that being physically active can be a protective factor.
Conclusions. There is a high prevalence of sleep disorders and insufficient practice of physical exercise among patients with fibromyalgia. It is suggested that regular physical exercise may be related to sleep quality, and more active participants have fewer sleep disorders, with exercise being a protective factor.
The evolving dynamics of Haredi Judaism in Israel: Ideological shifts and political influences
Authors: Chen Yanyan , Li Yong
Published: October 2024

This article analysed the evolution of Haredi Judaism in Israel, highlighting its deep-rooted fundamentalist beliefs and its transformation from a marginalised group to a central force in Israeli society. As the fastest-growing demographic, the Haredi community exemplified the tension between fundamentalism and modernity. The study explored the defining characteristics, political ideologies and social influence of Haredi Judaism in Israel, detailing how it transitioned from insular religious enclaves to active participants in national politics. The article also examined the Haredi impact on Israeli-Palestinian relations, focusing on their influence on party politics, land disputes and Jerusalem-related issues.Contribution: The study enhanced the understanding of Haredi Judaism’s ideological evolution and political integration within Israeli society. It highlighted the Haredim’s influence in shaping Israel’s national identity and policy directions. Additionally, the research elucidated the significant impact of the Haredi community on Israeli-Palestinian relations.
LSVT as a fundamental therapeutic technique for improving voice in parkinsonism: Evidence from three cases
Authors: Narayanan Nayana , Rahman Zaba N.
Published: October 2024

Lee Silverman Voice Treatment (LSVT) is one of the main treatments proposed for improving the loudness of hypokinetic dysarthria clients. It follows the modus operandi of training the client to achieve maximum loudness of voice with the highest effort and calibrating the voice at that level. It is very important to pool the evidence obtained from the patients to understand the effectiveness of the technique. My study aims to collect evidence of LSVT treatment from three patients with various stages and severities of Parkinsonism. Results reveal that the loudness level has significantly increased after LSVT treatment in comparison to pre-therapy levels. The percentage of shimmer value has decreased post-therapy. From the result, it is evident that LSVT was highly successful in elevating the loudness of all three clients. The reduction in shimmer percentage coincided with an improved overall quality of voice. Hence, we can conclude that LSVT is an apt treatment method for improving loudness in hypokinetic dysarthria clients.
Extendability of differential forms via Cartier operators
Authors: Kawakami Tatsuro
Published: October 2024

Let

X

be a normal variety over a perfect field of positive characteristic and

B

a reduced divisor on

X

. We prove that if the Cartier isomorphism on the log smooth locus of

(X,B)

extends to the entire

X

, then

(X,B)

satisfies the logarithmic extension theorem for differential forms. As an application, we show that the logarithmic extension theorem holds for good quotients of smooth varieties by actions of reduced linearly reductive group schemes. In addition, the logarithmic extension theorem for one-forms holds for singularities of higher codimension under assumptions about Serre’s condition. We also prove that tame quotients satisfy the regular extension theorem.
A consistent estimator for confounding strength
Authors: Rendsburg Luca , Vankadara Leena Chennuru , Ghoshdastidar Debarghya , von Luxburg Ulrike
Published: October 2024

Regression on observational data can fail to capture a causal relationship in the presence of unobserved confounding. Confounding strength measures this mismatch, but estimating it requires itself additional assumptions. A common assumption is the independence of causal mechanisms, which relies on concentration phenomena in high dimensions. While high dimensions enable the estimation of confounding strength, they also necessitate adapted estimators. In this paper, we derive the asymptotic behavior of the confounding strength estimator by Janzing and Schölkopf (2018) and show that it is generally not consistent. We then use tools from random matrix theory to derive an adapted, consistent estimator.
PhysiMeSS - a new physiCell addon for extracellular matrix modelling
Authors: Noël Vincent , Ruscone Marco , Shuttleworth Robyn , Macnamara Cicely K.
Published: October 2024

The extracellular matrix, composed of macromolecules like collagen fibres, provides structural support to cells and acts as a barrier that metastatic cells degrade to spread beyond the primary tumour. While agent-based frameworks, such as PhysiCell, can simulate the spatial dynamics of tumour evolution, they only implement cells as circles (2D) or spheres (3D). To model the extracellular matrix as a network of fibres, we require a new type of agent represented by line segments (2D) or cylinders (3D).
Here, we present PhysiMeSS, an addon of PhysiCell, introducing a new agent type to describe fibres and their physical interactions with cells and other fibres. PhysiMeSS implementation is available at https://github.com/PhysiMeSS/PhysiMeSS and in the official PhysiCell repository. We provide examples describing the possibilities of this framework. This tool may help tackle important biological questions, such as diseases linked to dysregulation of the extracellular matrix or the processes leading to cancer metastasis.
INTERRELATION OF PHARMACOLOGICAL QUALITIES VIZ; RASA- GUNAVIRYA-VIPAKA-PRABHAVA WITH RESPECT TO THEIR STRENGTH (BALABAL
NIRUPANA)
Authors: Verma Deepak , Kumar Sharma Ashwini , Shukla Megha
Published: October 2024

Ayurveda is founded on the Tridosha theory. The primary objective of the mind and the body is to establish
Tridosha balance, encompassing Vata, Pitta, and Kapha. When all three forms of dravyas (Jangam, Audabhid,
and Parthiva), i.e., food or drug, also pass through the human body, they elicit a reaction that impacts the
Tridoshas in either a positive or negative way. Drugs' therapeutic potential is also linked to qualities such as Rasa,
Guna, Virya, Vipaka, and Prabhava. These qualities of medication are known as Panchapadarthas or Pachagunas. Dravya's biological effects are substantially influenced by its inherent features, including Vipaka and
Prabhava. These pharmacological qualities contribute to the pacification of significant Tridoshas and restore
equilibrium between Dhatu, Mala, Srotas, and Agni. Their strength determines the interrelationship of these
pharmacological properties and their subsequent effect on one another is called Balabal Nirupana. Ancient Ayurvedic Acharyas and manuscripts explain some fundamental laws underlying this idea. This paper will discover
how a Dravya operates by applying ancient Ayurvedic principles.
EFFECT OF PUNNAGAVYOSHA CHOORNA PINDASWEDA IN TILATAILA AND
PATOLADI GANA KASHAYA IN VRISCHIKA VISHA: A RESEARCH ARTICLE
Authors: G Akhila , M Sanjay
Published: October 2024

Scorpion envenomation is a major public health problem in many rural areas of India. The annual number of scorpion sting cases exceeds 1.23 million, with over 32,250 (0.27%) potentially being fatal. Scorpion stings are primarily the result of accidental contact. Vrischika visha (scorpion envenomation) is of significant clinical im-portance due to the severity of local and systemic symptoms like Daha (Burning sensation), Ruk (Pain), Damsa-sopha (Oedema), Jwara (Fever), Chardi (Vomiting), etc. Acharya Vaghbata described Vrischika visha with pre-dominance of Vata dosha & the general line of treatment should be Vatahara. In this context, all ayurvedic text-books have mentioned Swedana as the first treatment procedure as it is Vatahara and Shoolahara. Choornapin-dasweda with Punnagavyosha choorna in Tilataila is one of the formulations mentioned in Keetadivisha prakarana in Kriyakoumudi, a traditional Malayalam Visha Chikitsa textbook. Ushna Teekshna gunas of Pun-nagavyosha choorna can act as Vatashamana. Tilataila is considered as the Agryoushadha for Vata. Patoladi-gana Kashaya which is mentioned in Ashtangahridayam is widely used in Visha conditions. This study was an interventional pre-post study with a sample size of 30. Subjects of the age group 16- 60 years, and those reported by the subject as scorpion sting and within 24 hours of the sting were selected for the study. A detailed case his-tory was taken according to the case proforma that included relevant signs and symptoms of Vrischika visha & Class I Scorpion Sting Syndrome. Subjects who have already undergone any other treatment for the same and with any other systemic or infectious diseases which may interfere with the study were excluded. Punnaga-vyosha choorna Pottali was dipped in warm Tila taila and gently applied over the sting site, after confirming the temperature (42oC – 45 oC), for 15 minutes to 45 minutes maximum or till symptoms are reduced at the affected site. After completing the procedure, 48 ml of Patoladigana Kashaya was given for internal administration. Choornapinda sweda and Patoladigana Kashaya were given for 3 days in total. Symptomatic assessment was done on 1st day - before the treatment, after 1 hour from starting of the treatment, on 2nd day, 3rd day and on 5th day (including follow up period of two days). The result shows there is a decrease in the mean score values of Vedana, Daha, Sopha and raktavarnata after Punnagavyosha choorna pinda sweda in Tila taila and Patoladi-gana Kashaya pana
TOXICITY DUE TO CHEMOTHERAPY & RADIOTHERAPY & ITS AYURVEDIC
APPROACHES
Authors: Ratnavat Anita
Published: October 2024

Chemotherapy and radiotherapy are the treatment modalities for cancer that are extensively used in current times
due to their effectiveness against many cancers. These therapies can cause severe toxicities, including loss of appetite, diarrhea, anorexia, constipation, vomiting, burning sensations, weakness, alopecia, and fever. Reduction in
hemoglobin, white blood cells, and platelets is among other adverse effects of chemotherapy. In this context,
Ayurveda can be an evidence-based proven approach to prevent and resist complications of cancer therapies. Several Ayurvedic drugs such as Brahmi, Brihamarasayan, Guduchi, Yasthimadhu, and Ashwagandha can help alleviate the side effects caused by chemotherapy and radiotherapy. These drugs also offer therapeutic benefits
against cancer. Ayurvedic medicines reduce the burning sensation induced by chemotherapy, improve digestion,
restore blood counts, remove toxins, and induce mental calmness. In this way, Ayurveda plays a significant role in
preventing and managing complications of chemotherapy and radiotherapy. There is a need to explore such approaches that counteract the side effects of chemotherapy and radiotherapy. Considering this fact, the present article explores the role of Ayurvedic modalities in preventing and managing chemotherapy and radiotherapy complications.
A COMPREHENSIVE REVIEW OF AGNI AND ITS ROLE IN THE ETIOPATHO-GENESIS OF THYROID DYSFUNCTION: A HIGHLY WIDESPREAD DISEASE
Authors: Bhavsar Toshi , Sharma Babita
Published: October 2024

Ayurveda is an alternative medicine system that originated in the Indian subcontinent. Ayurveda believes that the universe is made up of five elements: Vayu (air), Jala (water), Aakash (space or ether), Prithvi (earth), and Teja (fire). Ayurveda emphasises the maintenance and promotion of health and the prevention of diseases through various dietary and lifestyle regimens and the treatment of diseases through various therapeutic measures, substantiating the principle “Swasthasya Swasthya Rakshanam,” i.e., preserving the health of healthy persons, and “Aturashya Vikar Prasamanam,” i.e., curing the diseases of the diseased. Sushruta has described the features of a healthy person, i.e., doshas must be in equilibrium, the digestive fire (Agni) must be in a balanced state, and the tissues (Dhatus) and Malas (wastes) must work in a normal state. Agni regulates numerous metabolic reactions, including digestion and cell growth. It is related to a stance or entity that brings about transformation in any form. It supports healthy digestion, joy, and happiness and preserves body tempera-ture and complexity. Thyroid hormones play a crucial part in maintaining homeostasis in the body and function in food digestion at the GI level, which assists in biochemical reactions at the tissue level and helps convert het-erogeneous chemicals to homogeneous ones. An imbalance in Thyroid hormones plays a crucial role in metabol-ic processes. Thyroid hormone functioning can be normal or disordered, similar to Agni in Ayurveda. Agni leads to various metabolic disorders like thyroid disorders. So here, an attempt is made to address the essential func-tions of thyroid hormones as a part of Agni.
DOSHA, DUSHYA, MALA, AND PURVARUPA IN PRAMEHA: UNDERSTANDING EARLY SIGNS AND PATHWAYS
Authors: Nabil Barbhuiyan Shourav , Barman Niten , Dewan Manir , Kalita Shyamanta
Published: October 2024

Prameha, akin to diabetes mellitus in Ayurvedic medicine, is characterized by abnormal urinary discharge and systemic imbalances. This study explores the Ayurvedic concepts of Dosha, Dushya, and Mala to understand their roles in Prameha's pathogenesis and clinical manifestations. Through a review of classical texts and modern literature, the research highlights how vitiations in Doshas (Kapha, Pitta, Vata), affected Dhatus (Rasa, Rakta, Meda, Mamsa, Majja), and metabolic waste (Mala) contribute to the disease. It connects traditional Ayurvedic descriptions with contemporary understandings of diabetes, emphasizing the need to further integrate these in-sights into modern medical practices.
THE ROLE OF BASTI IN AGNIDEEPANA.
Authors: Sunil Joshi Tanvi
Published: October 2024

Ayurveda, being the science of life, believes that for the ‘Swastha’ state of the individual, Dosha, Dhatu, Mala
and Agni should be in ‘Sama’ Avastha along with harmony in Indriyas, Atma and Mana. Agni is considered the
most crucial entity in our body as it is the origin of our lives and maintaining health. Any abnormality in Agni
may cause a diseased condition, which in turn may be responsible for the death of an individual. To perform
chikitsa of any vyadhi, Vaidya should initiate with correction of Agni. There are many ways Agni Deepana is
explained in Ayurvedic classical texts, and Panchakarma is one of them. Basti karma, in particular,is praised as
the Best and Ardha Chikitsa. Basti karma plays an essential role in Agnideepana by acting on multiple factors
affecting Agni. Also, some specific basti formulations are explained in samhitas for Agni Deepana. This study is
an effort to understand the least considered Agni Deepana karma among all karmas of Basti, highlighting the
urgency of maintaining balance in Agni.
A CONCEPTUAL STUDY ON SHWETA PRADARA
Authors: Parbin Farida
Published: October 2024

The term "Shweta pradara" refers to whitish vaginal discharge, with "Shweta" meaning white and "pradara"
meaning discharge. While the term is not found in the primary classical texts, it has been used by commentators
such as Cakrapani on the Charaka Samhita and Vrinda Madhava. White vaginal discharge is a common symptom
in various gynaecological disorders linked to imbalances in kapha or vāta-kapha. It is a cardinal symptom in conditions such as Atyānanda, Karnini, Acarana, Aticarana, Slesmala, Upaplutā, and Prasramsini. It is prevalent
among women of reproductive age and is often caused by infections. In the perimenopausal group, Shweta pradara warrants careful investigation to exclude dysplasia or malignancy. Proper treatment protocols and maintaining hygiene can effectively manage and alleviate this condition.
A COMPREHENSIVE REVIEW ON VATAJA GRAHANI ROGA
Authors: Wahab Abdul , Kalita Ranjan , Kalita Shyamanta
Published: October 2024

Grahani (duodenum) is regarded as the seat of Agni (digestive fire) and is sustained by its strength. Any factor
that disrupts the normal function of Jatharagni (a type of digestive fire) can lead to Grahaniroga (Diarrhoea/Dysentry). Grahaniroga is categorised into different types based on the involvement of Doshas. Among all
the kinds of Grahaniroga, Vataja Grahani Roga is more common and can be correlated with Irritable Bowel
Syndrome (IBS). The causes of Vataja Grahani are primarily factors that aggravate Vata dosha. These include
Katu, Tikta, Kashaya, Rooksha and Sheeta. The consumption of factors that aggravate Vata dosha leads to vitiated Vata enveloping the digestive fire (Agni), resulting in Manda Agni, or weak digestive fire. This condition causes delayed and difficult digestion, leading to Shukta paka forming, where the food becomes acidic. In Charaka
Samhita, the treatment for Vataja Grahani is explained in detail. These include Aam Pachana, Deepaniya Ghrita,
Anuvasana Basti,Virechana and Niruha Basti.
ERGONOMICS IN AYURVEDA- A CRITICAL REVIEW
Authors: Shetty Srinidhi , Kaur Prabhjot , Kamath Surekha , Kumari Ankita , K Sharma Surendra
Published: October 2024

Ayurveda is referred to as a "complete health science" because it strongly emphasises maintaining good health
and preventing illness in addition to treating current conditions. The preservation of health, or Swastasya swastya
Rakshana, is the primary goal of Ayurveda. Ergonomics is the safe and practical design of objects for human use
in a way that minimizes hazards. Although ergonomics is a relatively new field in the modern world, Ayurveda
has discussed it in Vishamasana and emphasises the characteristics of furniture used, and various health conditions brought on by incorrect posture and seated patterns. Thus, this study is an initial attempt to clarify the risks
associated with postural ergonomics, their impact on health, and how Ayurveda might help control them.
CHARAKOKTA RUTU-TRIVRIT ; AN UNIQUE CONCEPT.
Authors: - Bindiya , V Rao Mamatha , Veena M S
Published: October 2024

Trivrit (Operculina terpethum ) that has been widely used for its excellent therapeutic effect, since vedic period
till date. According to acharya charaka, trivrit is an agrya dravya for sukha virechana. In classics, administration
of drugs has been given prime importance in accordance with bala, agni, rutu, anupana etc. In this regards,
Acharya charaka has explained very unique concept in kalpa sthana, known as Rutu Trivrit.
ROLE OF PATHYA APATHYA IN NETHRA SWASTHYA (EYE HEALTH)-A RE-VIEW
Authors: Sharma Rajkumar , Nama Jagdish , Sharma Monika
Published: October 2024

Since Ayurveda places a high value on both disease prevention and treatment, it is important to preserve health.
Through their explanation of Pathya Apathya, the Acharyas have equipped us with the necessary knowledge to
prevent and manage lifestyle issues related to eye diseases. Daily observations assessed the effectiveness of specific dietary habits and medications in preventing eye disorders. pathya apathya is used to explain certain parts of
daily routine. The word "Chakshu" means "which enlightens the mind about its details and illuminates the objects." The term Chakshushya is crucial when discussing Pathya and Apathya since it is used in classic literature
to describe the effects of consuming specific beneficial regimes (Pathya) and nonbeneficial medications and practices (apthya), among other things. Various ahar vargas, which list the qualities of every food item, have been
referenced in ancient scriptures. With this understanding, we may choose our meals carefully and follow a daily
routine to maintain netra swasthya, or eye health.
MANAGEMENT OF PARIKARTIKA W.S.R. TO FISSURE IN ANO BY APPLICA-TION OF KALANUSARYADI TAILA PICHU -A CASE STUDY
Authors: Nilima Pandey , Balendra Singh , Satrupa Nirmal , Sunidhi Bara
Published: October 2024

Ayurveda is a natural science which not only cures disease but also prevents disease. Ayurveda is a beautiful path to lead a disease-free life . Nowadays due to sedentary lifestyle many diseases affect mankind, among them Parikartika is the most common one. In Ayurveda Aushadhachikitsa of Parikartika includes Deepniya, Pachni-ya, Ropaniya, Vatanulomak, Virechaka Aushadha and local therapies include Matrabasti, Snehabasti, Pichudharan, Tail Puran, Lepa , Madhura Kashaya Dravya Siddha Basti. Pichudharana works on the basis of cellular absorption and is an easier method for adoption. CONCLUSION : A case with the features of Pari-kartika was selected from OPD, Govt Ayurveda College and Hospital, Raipur, C.G. for case study and Kalanusaryadi Taila Pichudharan was done for 1 month. Assessment was done based on features like pain, burning sensation,bleeding, sphincter tone. Significant improvement was observed after treatment.
AYURVEDIC MANAGEMENT IN MALE INFERTILITY W.S.R TO OLIGO ASTHENOSPERMIA: A CASE REPORT
Authors: Shantikar Niketa , Deshmukh Neeta
Published: October 2024

Infertility is a disease of the male or female reproductive system defined by the failure to achieve a pregnancy
after 12 months or more of regular unprotected sexual intercourse[WHO]3
. Infertility may occur due to male, female or unexplained factors[WHO].In the male reproductive system, infertility may be caused by abnormal sperm
function and quality [WHO]. Oligoasthenospermia is a condition with a decrease in the concentration of the
spermatozoa and the percentage of motile spermatozoa in a sperm sample. A 36-year-old male patient with no
issues for six years of marital life diagnosed with oligoasthenospermia visited our OPD in July 2022. Initially advised with Nitya Virechana, followed by Chandraprabha Vati and Burundi kashaya given after that, Tablet chandraprabha vati, Tab Confido, Tab Tentex forte and Tab Rejuspermin have been provided for six months. Followup showed improvement in seminal parameters regarding sperm concentration and motility, resulting in pregnancy. The present case signifies the importance of Ayurvedic treatment in bringing successful outcomes in the field
of male infertility.
AYURVEDIC PROPRIETARY INTERVENTION IN LEUCODERMA (SHVITRA): A
CASE STUDY
Authors: Badyal Sakshi , Dang Poonam , Dhawan Puneet , Shekhar Tiwari Himanshu
Published: October 2024

Ayurveda mentions all types of skin disorders under one common term i.e., Kushtha Roga. Shvitra is explained in
the classics as a type of Kushtha. The disease is said to be result of impairment of Tridosha and Dhatu such as
Rakta, Mamsa and Meda. Signs and symptoms of Shvitra and vitiligo resemble closely, hence the two diseases
are co-related as well. The cause of vitiligo is yet unclear and is believed to be an auto-immune disease. Modern
science has limited treatment options to address this concern. Whereas, in Ayurveda, although the disease is
termed as Kricchasadhya (difficult to treat) or Asaadhya, yet many treatment options are advised. This case report
elucidates the therapeutic effect of Ayurveda treatment modality in a patient having progressive leucoderma. A
21-year-old female patient with complaints of whitish-lesions over forehead, neck and back having moderate itching and pre-diagnosed with leucoderma visited our OPD. After the treatment for 11 months, significant changes
were observed in the shape and size of lesions.
EFFECT OF AYURVEDA TREATMENT MODALITY IN IMPROVING CHRONIC KIDNEY DISEASE: A CASE REPORT
Authors: Dang Poonam , Badyal Sakshi , Dhawan Puneet , Tiwari H.S.
Published: October 2024

Chronic kidney disease (CKD) is a progressive condition augmenting over years, entailing loss of kidney functions, affecting more than 10% of the general population worldwide. The solution of choice is either kidney transplantation or blood purification treatments such as hemodialysis (HD). Such medical procedures are expensive &
arduous for the patients, adversely impacting their quality of life. Hence alternative treatment modalities are copiously perceived seeking restoration. In the present study, 50 year-old female patient approached the hospital OPD
for consultation with complaints of weakness, constipation, reduced appetite, weight loss, breathlessness etc.
Patient was advised Ayurveda treatment along with dietary restriction. After 2 months of treatment significant improvement was seen, there was a gradual decrease in Serum Creatinine levels from 6.05 mg/dl to 2.20 mg/dl,
Blood Urea levels from 80mg/dl to 64mg/dl and Uric acid levels from 4.4mg/dl to 3.0 mg/dl .The case clearly reveals the noteworthiness of Ayurveda treatment modality in the management of CKD.
PHYSIOLOGICAL ASPECT OF AALOCHAK PITTA PERSPECTIVE OF THE MODERN ERA
Authors: - Neelam , Chandra Sharma Dinesh , Kumar Sharma Rajesh
Published: October 2024

Ayurvedic science is based on Dosha, Dhatu, and Mala Vijnana. The body's origin and maintenance depend upon
the three primary and fundamental units or principles: Doshas Vata, Pitta, and Kapha. The first Aacharya to categorise Pitta Dosha into five categories was Sushruta. Rupa grahana, or the perception of vision, is attributed to
the Pitta known as Alochaka Pitta, located in the retina (Drishti). Acharya Bhela has divided this Alochaka Pitta
into two categories: intellectually (Buddhi) and visually or optically (Chakshu’s) differentiative. An example of
an optically differentiative Pitta creates a differentiation by placing a picture. The visual process, also known as
the physiology of vision, is the mechanism by which the outside world is perceived. Specialised cells called photoreceptors start the process that turns light rays into nerve impulses. There are two categories of photoreceptors:
Rodes and cones.
AYURVEDIC MANAGEMENT OF CHRONIC ALLERGIC RHINITIS W.S.R TO PRATISHYAYA: A CLINICAL CASE STUDY.
Authors: Singh Devjinder , Pohiya Ritu
Published: October 2024

Chronic allergic rhinitis is a common nasal condition characterized by persistent inflammation of the nasal membranes triggered by allergens. Allergic rhinitis, often called hay fever, inflammation, and discomfort, signif-icantly impacts the quality of life. In Ayurvedic classics, this condition is associated with Pritishyaya, which is mentioned in Nasagata roga. Objective: This study aims to explore the Ayurvedic management of chronic rhini-tis, with a focus on understanding and treating the five types of Pritishyaya, i.e. Vataja, Pittaja, Kaphaja, Rakta-ja, Sannipataja. Methods: A clinical case study involved a patient with chronic rhinitis. Symptoms such as nasal congestion, rhinorrhea, sneezing, watery eyes, and post-nasal drip were evaluated and notably aggravated by certain factors, including curd (yogurt) consumption, exposure to cold environments (such as air conditioning), and exposure to dust, etc. The patient’s condition was classified according to Ayurvedic principles, and a tai-lored treatment regimen, including dietary changes, herbal remedies, and lifestyle adjustments, was implement-ed. Results: The treatment led to significant improvements in the patient’s symptoms, including reduced nasal congestion and discharge, decreased sneezing, and enhanced overall comfort. The personalized approach proved effective in addressing the specific type of Pritishyaya. Conclusion: The study highlights the efficacy of Ayur-vedic treatments in managing chronic rhinitis and emphasizes the importance of individualized care. The find-ings support integrating Ayurvedic methods into contemporary clinical practice and suggest further research to explore their broader applicability.
AYURVEDIC MANAGEMENT OF KSHEENA SHUKRA (OLIGOSPERMIA) LEAD-ING TO MALE INFERTILITY: A CASE STUDY
Authors: D K Rajarama , N G Ambika
Published: October 2024

As per the World Health Organization (WHO) report in India, the overall prevalence of primary infertility ranges
between 3.9 and 16.8%. A recent report on the status of infertility states that 50% of it is related to productive
anomalies or disorders in males. In comparison, 90% of male infertility problems are related to Oligospermia and
other abnormalities in semen analysis. As per Ayurveda, Oligospermia can be considered as Ksheena Shukra (Oligospermia). Surgery, Hormone treatments, medications and Assisted Reproductive Technology (ART) are the
main lines of treatment in Conventional medicine, but these are associated with many unwanted and severe adverse effects. The present case discussion is about effectively managing a case diagnosed as Ksheena Shukra with
Ayurvedic intervention. This case report aims to evaluate the effect of Ayurvedic treatment in managing Ksheena
Shukra. In this case study, Shodhana (Purificatory Therapy) procedures {especially Virechana Karma (Purgation)
and Vasti(Enema)} were performed before administering Rasayana (Rejuvenation) drugs; the pre- and postsemen analysis during the treatment period shows a marked increase in sperm count and motility. The outcome of
this case reveals that Ayurvedic treatments can effectively manage the Oligospermia associated with male infertility.
FRACTAL MOTIF OF ‘GARUDA NGUPUK’ IN LOKATMALA BATIK DESIGN WITH SUNDANESE SCRIPT
Authors: PUTRA YEFFRY HANDOKO , HIDAYATULLAH TAUFAN , WAHDINIWATY RAHMA
Published: October 2024

In traditional Indonesian batik, intricate designs reflect the nation’s rich heritage. This study explores the use of fractal geometry, specifically the ‘Garuda Ngupuk’ motif, in evolving Lokatmala Batik designs known for their complexity and elegance. Inspired by Sundanese script, this research paper highlights how fractal curves can rejuvenate traditional batik artistry. Using digital design techniques alongside traditional craftsmanship, the study creates intricate Lokatmala Batik patterns that merge Sundanese cultural essence with modern geometric motifs. This fusion of tradition and innovation showcases Lokatmala Batik as a testament to the enduring beauty and adaptability of this Indonesian cultural heritage on a global stage.
INNOVATIVE MATHEMATICAL MODELLING IN PREDATOR-PREY DYNAMICS: A SYSTEMATIC REVIEW
Authors: WAN SAMPERISAM WAN SITI NOOR SOFEA , MOHD ROSLAN UMMU ATIQAH , NOOR HASSIM MUHAMAD FAIRUS
Published: October 2024

Advancements in mathematical ecology have greatly expanded predator-prey models beyond the classical Lotka-Volterra framework, incorporating complex factors such as role reversal, fractional calculus, and the Allee effect. This review highlights innovative models and advanced mathematical techniques that enhance our understanding of predator-prey dynamics and their applications across disciplines. It analysed recent studies introducing new ecological factors, including maturation delays, disease dynamics, and spatial heterogeneity. Techniques like fractional calculus and network theory were examined for their effectiveness in capturing complex behaviours. Models addressing role reversal between adult prey and juvenile predators or incorporating generalized fractional derivatives reveal significant impacts on population stability. Additionally, maturation delays, handling time, and gestation periods markedly influence oscillatory dynamics. The reviewed models demonstrate versatility in guiding pest control, understanding disease spread, and optimizing biotechnological processes. This review shows that modern predator-prey models, enriched by complex ecological factors and advanced mathematics, provide profound insights into system dynamics, with practical applications across various fields. As global challenges grow, these models offer crucial guidance for developing more resilient and sustainable systems, underscoring their potential to addressissues like food security, disease outbreaks, and ecosystem degradation. Future research should integrate emerging factors, such as anthropogenic noise and industrial pollutants, to further enhance the models’ real-world relevance.
EXPLORING THE BENEFITS, CHALLENGES AND GUIDELINES OF DEVOPS ADOPTION: A SYSTEMATIC LITERATURE REVIEW AND AN EMPIRICAL STUDY
Authors: HAMZA USMAN , SYED-MOHAMAD SHARIFAH MASHITA , ABDULLAH NASUHA LEE
Published: October 2024

This study aims to explore the benefits and challenges of DevOps adoption in the rapidly evolving landscape of DevOps and Information Technology (IT) firms. DevOps is a software development approach that emphasises communication and collaboration between software developers and IT operations teams, aiming to streamline processes and enhance software delivery. Despite the growing popularity of DevOps, there are several challenges to its adoption, including stakeholder confusion, a lack of clear processes and guidelines, and a lack of empirical studies that discuss the challenges of DevOps. To establish a foundation of understanding and provide insights into the benefits, challenges, and guidelines for DevOps adoption, this study uses a two-fold approach, including a systematic literature review and conducts semi-structured interviews involving six organisations of various sizes. The interviews aimed to obtain evidence of DevOps adoption in practice and to detail real scenarios and explain the role of each category during DevOps adoption. The study provides insights into the challenges faced by software organisations in adopting the DevOps culture and the benefits of DevOps adoption. The study also proposes DevOps adoption guidelines based on the findings. The findings contribute to the existing literature on DevOps adoption and provide valuable recommendations for software organisations.
A REVIEW ON MACHINE LEARNING AND DEEP LEARNING TECHNIQUES FOR TEXTUAL EMOTION ANALYSIS ON SOCIAL NETWORKS
Authors: KHAN RAHMAT ULLAH , CHE ALHADI ARIFAH , ALI NORAIDA
Published: October 2024

In recent times emotion detection has achieved significant attention in the field of Natural Language Processing (NLP) due to the abundance of text data available on different social network platforms like Twitter, LinkedIn and Reddit. This paper presents a thorough review of existing emotion detection techniques on text analysis. The methodology involves a comparative analysis of different machinelearning and deep learning models, approaches and datasets utilised for emotion detection. The article discusses the limitations and challenges of traditional methods and delves into the theoretical foundations of machine learning and deep learning techniques such as SVM, CNN and BERT. By exploring the current state-of-the-art in emotion detection from social networks, this review aims to provide insight for researchers to advance the field of emotion detection.
Pengaruh Electronic Word of Mouth Terhadap Minat Beli di Rumah Sakit Melinda 2
Authors: Alamsyah Rifa Azizah , Yuliaty Farida , Irawan Debi
Published: October 2024

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh E-WOM (electronic word of mouth) terhadap minat beli paket Medical Check Up (MCU). eWOM adalah suatu pernyataan dari konsumen berisi pendapat atau ulasan yang singkat dan padat baik positif maupun negatif. Penelitian ini menggunakan metode kualitatif dengan teknik pengumpulan data berupa literature review, observasi, dan wawancara dengan anggota tim marketing. Hasil penelitian ini menunjukkan bahwa eWOM merupakan salah satu teknik marketing yang dapat berpengaruh terhadap minat beli.
The Distribution of Acme Gene and MRSA Related Virulence Genes in Staphylococcus Aureus Strains from Nigeria
Authors: Terry Alli Oyebode Armstrong
Published: October 2024

Background: Arginine Catabolic Mobile Element (acme) is a Staphylococcal genomic island that enhances fitness and ability of bacteria cells to colonize on mucous membrane and skin. It is stongly associated with the epidemic and virulent S. aureus USA 300. This study determined the distribution of acme and Methicillin Resistant Staphyllococus Aureus (MRSA)-related genes in S. aureus isolated from patients in five tertiary hospitals in Nigeria.

Methods: A total of 51 S. aureus isolates from the clinical specimens submitted to laboratories in five tertiary hospitals in Nigeria were used in this study. Phenotypic and genotypic identifications of the S. aureus were performed. Antibiotic Susceptibility Test (AST) was carried out to determine the susceptibility pattern of the isolates using various antibiotics discs. Minimum Inhibitory Concentration (MIC) was used to determine the degree of resistance of the isolates to methicillin and vancomycin. Polymerase Chain Reaction (PCR) was used to screen for the presence of mecA, acme sae, sarA, PVL, α-psm and norB genes using specific primers. The SCCmec type was determined for all the MRSA isolates using polymerase chain reaction.

Results: The MIC for mecA negative strains was ≤4 µg/ml, while the MIC for mecA positive was 8 µg/ml. mecA gene was detected in 35 (68.6%) of 51 strains of S. aureus. The prevalence of sae, sarA, mecA, acme, PVL, α-psm and norB gene were estimated to be 70.6%, 68.6%, 68.6%, 29.4%, 5.1%, 39.2% and 33.3% respectively. There was an association between the distribution of mecA+ and norB+ strains (P = 0.034) and the hospitals (P =0.008) where the isolates were obtained from, whereas there was no association between acme positive strains and the hospitals (P = 0.669) from which the isolates were obtained from. Also, there was no association between mecA, norB, acme with the sex, age and hospital admission status (P>0.05). Furthermore, there was an association between PVL gene and the two geographical regions (South-Western and North-Western, Nigeria) (χ2 = 7.77; p < 0.05). The SCCmec typing showed that 21 (60.0%) out of the 35 MRSA used in this study carried the SCCmec type elements such as type I, II, III and VIII which were all the characteristic of HA-MRSA while the remaining 14 (40%) carried the SCCmec type elements such as type IV, V, VI and VII which were all characteristic of CA-MRSA. Thus the overall prevalence of HA-MRSA and CA-MRSA in this study was 60.0% and 40.0%, respectively.

Conclusion: The prevalence of acme and α-psm genes in S. aureus are high and this is a novel discovery in Nigeria which has opened a new era in the transmission and fitness of circulating MRSA in causing infection in the community at large. The study concluded that there is high prevalence of HA-MRSA in South-Western, Nigeria and high prevalence of CA-MRSA in the North-Western, Nigeria.
Impact of Sex, Age and Body Habitus on RBD-specific Antibody Response After Two Doses of Sinopharm BBIBP-CorV Vaccine
Authors: Sandag Tsogtsaikhan
Published: October 2024

Background: Mongolia started its nationwide vaccination campaign against COVID-19 on 23 February 2021 after receiving the first batch of the inactivated BBIBP-CorV. Age and body habitus of vaccinees may be associated with the immune effecter functions. Several systematic reviews and meta-analyses suggested lower immunogenicity of vaccines against SARS-CoV-2 infection in the older adult population and obese individuals. We aimed to establish a possible relationship between post-vaccine seroconversion rate and some biometric characteristics in the Mongolian cohort of vaccinees after two shots of the Sinopharm BBIBP-CorV vaccine.

Materials and Methods: We collected serum samples from 846 eligible vaccinees before the first dose of the BBIBP-CorV vaccine and 21-28 days after the second dose of the same vaccine. Anti-SARS-CoV-2 Receptor Binding Domain (RBD) Immunoglobulin class G (IgG) and M (IgM) titer were measured in all samples.

Results: 686 (81.1%) of 846 vaccinees received the Sinopharm BBIBP-CorV vaccine demonstrated seroconversion. Vaccinees with seroconversion had a younger mean age and lower mean body-mass index (BMI) than non-responders. Seroconversion rate according to age of vaccinees tends to decrease and obese vaccinees demonstrated a greater portion among non-responders. The Optimal Cut-Point (OCP) of age for seroconversion was found to differ significantly in male and female vaccinees. BMI has shown prediction ability for seroconversion only in male vaccinees but not in females. Using Receiver Operating Characteristics (ROC) analysis, we found 39 years for males and 41 years for females as a crucial milestone increasing the probability of seronegativity 2.5 times on average. A BMI higher than 29.1kg/m2 in male vaccinees was considered an acceptable predictor for seroconversion increasing the probability of seronegativity 2.4 times on average.

Conclusion: The above findings allow us to summarize the sex-adjusted approach to biometric characteristics has an improved predictiveness for post-vaccine antibody response.
Dengue Fever in Urban Bangladesh: Atypical Presentations and Platelet Count Dynamics
Authors: Shahidul Islam Syed Mahmood
Published: October 2024

Dengue fever, an arboviral infection transmitted by Aedes mosquitoes, remains a significant public health challenge in urban Bangladesh, especially in densely populated areas like Dhaka. This retrospective study investigates atypical clinical manifestations and platelet count dynamics among dengue patients, analyzing the association between thrombocytopenia and disease severity. Twenty patients treated in Dhaka were analyzed for clinical and hematological markers, with a specific focus on atypical presentations and platelet-hematocrit correlations. The findings highlight that while thrombocytopenia is a well-established indicator of dengue severity, several patients with critically low platelet counts did not exhibit typical warning signs, necessitating a more nuanced clinical approach.
Functional Upper Limb Assessment After Sternal Clavicular Joint Resection Without Prosthetic Reconstruction
Authors: de Macedo João Paulo Cassiano
Published: October 2024

The Sternal Clavicular Joint (SCJ) resection is used as a treatment for SCJ infections. Reconstruction with a prosthesis can lead to reinfection, but theoretically, it is preferable due to functional impairment risk. However, the post-operative functional upper limb evaluation is poorly documented. The objective is to assess the upper limb function after SCJ resection and reconstruction without a prosthesis to determine if there is any functional impact and to grade it.

We performed clinical and functional evaluations of patients with SCJ resected and reconstructed without prosthesis as treatment of SCJ infection in the period between 2012-2018. The evaluation was composed of a questionnaire (pain scale and daily activity evaluation) and examination (inspection, mobility and strength). 9 patients were assessed, from whom 7 had unilateral surgery. The questionnaires regarding pain and daily activities limitations showed improvement in 100% of the cases. Just one case of possible nerve injury with paresthesia. On the physical exam, only small alterations on inspection were found in 8 patients. Mobility was considered normal in 33%, partially impaired in one test in 22% and partially impaired in two or more tests in 44% of cases. Strength was graded 5 (maximum strength) and symmetric in seven patients. Patients after SCJ resection without prosthetic reconstruction showed a good outcome, especially on pain and daily activity. Even though, a small impact in mobility and strength has occurred.
Exploring Teacher's Effective Strategies in Catch-Up Fridays in Addressing Reading Gap
Authors: Rominimbang Amer M. , Rominimbang Noraifa S. , Barrera Kenneth Ian B.
Published: October 2024

The Covid-19 pandemic made a lot troubles in the educational field particularly in the area of reading proficiency. In response to this problem, the Department of Education in the Philippines implemented the Catch-up Fridays initiative which is dedicated to intensive remediation on selected areas. In this study, reading remediation is the focus. The study aimed to evaluate the effectiveness of various teacher strategies used in the sessions. Using a descriptive qualitative research approach, data were collected through semi-structured interviews with 13 purposively sampled teachers. The findings highlight the use of Philippine Informal Reading Inventory as key assessment tool and preference for strategies such as peer tutoring, and content-based instruction. However, challenges such as time constraints, insufficient resources, and lack of structured curriculum were identified. Despite the challenges posed by the situation, teachers demonstrated commitment on the program and in enhancing student outcomes. The study concludes that while Catchup Fridays show potential in addressing reading problems, its success hinges on adequate support such as resources and improved guidelines. The findings underscore the need for continuous improvement and support to optimize the program’s impact on reading proficiency.
Student Worksheets Literacy-Based to Improve High-Level Thinking Skill
Authors: Sembiring Irawati Br , Hadi Wisman , Pramuniati Isda
Published: October 2024

This research is motivated by the lack of availability of LKPD that supports literacy activities to improve high-level thinking skills. This type of research is Research and Development (R&D) with the ADDIE model development method. The discussion of the research is adjusted to the ADDIE research and development procedures, namely: analyze, design, development, implementation, and evaluation. The subjects of this study were 24 students of grade V SDN 101867 Payagambar. Determination of the level of feasibility of LKPD or Student worksheets is based on expert validation tests and trials on students through student response questionnaires. The effectiveness of LKPD was obtained from the results of the pretest and posttest of grade V students. The results of this study indicate that the validation of material experts was 80% with a feasible category, validation of language experts was 85.41% with a very feasible category, validation of layout design experts was 90.47% with a very feasible category. The percentage results of the student response questionnaire were 86.70 which were categorized as very feasible, so it can be said that LKPD is feasible for use by grade V elementary school students. The results of the student pretest reached an average score of 69.3 with classical completeness reaching 42% with an incomplete category. While the results of the posttest after using LKPD reached an average of 84.50 with classical completeness reaching 100% and declared complete. Based on the pretest and posttest values, the gainscore value can be seen as 0.51 with a moderate effectiveness category. This shows that the use of literacy-based LKPD to improve high-level thinking skills has been effectively used by grade V students of SDN 101867 Payagambar, Batang Kuis District.