bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract 64: Abnormal splicing events in adenoid cystic carcinoma
Authors: Leonard Brandon , Humtsoe Joseph O. , Kim Hyun-Su , Ling Shizhang , Marchionni Luigi , Fertig Elana J. , Considine Michael , Ha Patrick
Published: December 2017

Salivary gland adenoid cystic carcinoma (ACC) is a relatively rare and understudied malignancy. While this disease can often be controlled locally by surgery and radiation therapy, distant metastases occur in nearly 50% of cases. Interestingly, these metastases can remain asymptomatic for several years, and there are currently no factors that are known to contribute to their dormancy or aggressiveness. Furthermore, there are no targeted chemotherapeutic agents available to treat any stage of this disease.

To identify aberrations that contribute to ACC tumorigenesis, we performed whole genome methylation profiling, RNA sequencing, and exome sequencing on 18 primary ACC tumors and matched normal salivary gland tissue. A novel analysis methodology of Splice Expression Variability Analysis (SEVA) coupled with outlier statistical analyses of mRNA splice junctions revealed the presence of several abnormal splicing events (ASEs) in the studied tumors. Interestingly, the ASEs were significantly overrepresented in tumors as compared to matched normal salivary gland tissue. In vitro analyses found that many of the ASEs are also expressed in the only validated ACC cell line, MDA-ACC01, and multiple patient-derived xenograft (PDX) models of ACC. Overall, these studies have identified an unanticipated aberration in ACC and developed a model in which to study ASEs. Future work will be aimed at determining the functional impact that ASEs have on tumor initiation and growth.

Citation Format: Brandon Leonard, Joseph O. Humtsoe, Hyun-Su Kim, Shizhang Ling, Luigi Marchionni, Elana J. Fertig, Michael Considine, Patrick Ha. Abnormal splicing events in adenoid cystic carcinoma [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 64.
Abstract 73: Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cell by targeting forkhead transcription factors FOXO3a and FOXM1
Authors: Tanaka Noriaki , Zhao Mei , Zhang Jiexin , Wang Jing , Zhou Ge , Myers Jeffrey N.
Published: December 2017

Many mutant p53 proteins exert oncogenic gain-of-function (GOF) properties in promoting cancer cell invasive growth and metastasis, but the mechanisms mediating these functions largely remain elusive. We show here that overexpression of the GOF mutant p53 G245D and other GOF p53 mutants enhances invasive cell growth of p53-deficient head and neck squamous cell carcinoma (HNSCC) UM-SCC-1 cells both in vitro 3D culture and in vivo orthotopic tumor mouse model. We demonstrate that the expression of the oncogenic forkhead transcription factor FOXM1 is upregulated by GOF mutant p53s in UM-SCC-1 cells and tumors. Moreover, we show that overexpression of GOF mutant p53 G245D decreases the inhibitory phosphorylation of FOXO3a, a tumor suppressive forkhead transcription factor, leading to its cytoplasmic accumulation. Consistent with the observation that FOXO3a negatively regulates FOXM1 expression, we demonstrate that overexpression FOXO3a decreases GOF mutant p53-mediated FOXM1 expression, whereas downregulation of FOXO3a partially restores decreased FOXM1 expression due to loss of GOF mutant p53. In support of the roles of FOXO3a-FOXM1 signaling axis in mutant p53's GOF signaling, we further show that overexpression of FOXO3a or downregulation of FOXM1 impairs GOF mutant p53-mediated cell invasion, whereas downregulation of FOXO3a, in part, rescues impaired cell invasion due to downregulated GOF mutant p53. Finally, given that AMP-activated protein kinase (AMPK) directly phosphorylates and promotes FOXO3a function, and that our prior demonstration that GOF mutant p53s inhibit AMPK, our current study establishes that GOF mutant p53-AMPK-FOX3a-FOXM1 signaling is one of important mechanisms through which mutant p53s gain oncogenic functions in HNSCCs.

Citation Format: Noriaki Tanaka, Mei Zhao, Jiexin Zhang, Jing Wang, Ge Zhou, Jeffrey N. Myers. Gain-of-function mutant p53 promotes the oncogenic potential of head and neck squamous cell carcinoma cell by targeting forkhead transcription factors FOXO3a and FOXM1 [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr 73.
Abstract IA10: Integrated omics analyses identify prognostic biomarkers of oral cavity squamous cell carcinoma in Taiwan
Authors: Chang Kai-Ping , Chen Ting-Wen , Pickering Curtis R. , Myers Jeffrey N. , Chang Yu-Sun
Published: December 2017

To uncover genomic alterations that can be used as molecular markers for oral cavity squamous cell carcinoma (OSCC) in Taiwan, we recruited patients who were ethnically Taiwanese and admitted to Chang Gung Memorial Hospital at Taipei. We performed whole-exome sequencing (WES) of matched tumor/PBMC DNAs from 50 OSCC patients (75-Mbp target region, mean depth = 244 ± 54), and RNA sequencing of matched tumor/adjacent normal tissues from 39 of the 50 patients (mean read count = 38.7 ± 15.2 million). A subset of the identified somatic mutations was validated in 49 tumor tissues using an IonAmpliSeqTM Comprehensive Cancer Panel (CCP; 409 cancer-related genes). In total, our exome sequencing analyses uncovered 33,160 somatic single nucleotide variants (SNVs) and InDels. The targeted approach of CCP enabled us to independently validate 84.91% of the SNVs identified by our whole-exome sequencing. We cross-referenced our data with that of 172 oral cavity cancer samples (OSCC-TCGA) from the Head-Neck Squamous Cell Carcinoma (HNSC) project of TCGA (HNSC-TCGA) and 106 from India (OSCC-India), as annotated in the International Cancer Genome Consortium (ICGC). We found that our patient cohort was characteristic of OSCC with regard to frequently mutated genes, such as CDKN2A, TP53, and NOTCH1. Interestingly, however, our analysis further identified mutations in seven other genes that turned out to be unique, locally prevalent (>10% of patients) alterations. We further used our exome sequencing data to examine copy number alterations in our samples and our findings largely recapitulated the profile found in OSCC-TCGA, which included significantly amplified/deleted regions encompassing genes such as EGFR, FGFR1, FADD, FAT1 and CDKN2A. Comparative analysis of the transcriptomes of tumor and normal tissues allowed us to identify 3,548 genes as being differentially expressed in OSCC-Taiwan; these included 1,220 up-regulated and 2,328 down-regulated genes. Notably, 91.3% of these differentially expressed genes were similarly identified in the OSCC-TCGA data, indicating that the overall expression profile of OSCC is highly similar across ethnic groups. In the meeting, I will report the unique genomic alterations with the potential biomarkers in OSCC, and these findings might introduce a hitherto unknown genetic component of this disease.

Citation Format: Kai-Ping Chang, Ting-Wen Chen, Curtis R. Pickering, Jeffrey N. Myers, Yu-Sun Chang. Integrated omics analyses identify prognostic biomarkers of oral cavity squamous cell carcinoma in Taiwan [abstract]. In: Proceedings of the AACR-AHNS Head and Neck Cancer Conference: Optimizing Survival and Quality of Life through Basic, Clinical, and Translational Research; April 23-25, 2017; San Diego, CA. Philadelphia (PA): AACR; Clin Cancer Res 2017;23(23_Suppl):Abstract nr IA10.
Report on the Third FDA–AACR Oncology Dose-Finding Workshop
Authors: Emens Leisha A. , Bruno Rene , Rubin Eric H. , Jaffee Elizabeth M. , McKee Amy E.
Published: December 2017

The FDA–AACR Oncology Dose-Finding Workshop, Part 3, was held in Washington, DC, on July 20, 2017, as a continuation of the previous two collaborative dose-finding and optimization workshops presented by the FDA and AACR. This year's workshop focused on combination therapy with immune-oncology agents and best practices regarding patient and dose selection, predictive biomarkers, and novel clinical endpoints. This summary highlights viewpoints that emerged during the workshop. Cancer Immunol Res; 5(12); 1058–61. ©2017 AACR.
Cuff-Based Oscillometric Central and Brachial Blood Pressures Obtained Through ABPM are Similarly Associated with Renal Organ Damage in Arterial Hypertension
Authors: Fernández-Llama Patricia , Pareja Júlia , Yun Sergi , Vázquez Susana , Oliveras Anna , Armario Pedro , Blanch Pedro , Calero Francesca , Sierra Cristina  , de la Sierra Alejandro 
Published: December 2017

Background/Aims: Central blood pressure (BP) has been suggested to be a better estimator of hypertension-associated risks. We aimed to evaluate the association of 24-hour central BP, in comparison with 24-hour peripheral BP, with the presence of renal organ damage in hypertensive patients. Methods: Brachial and central (calculated by an oscillometric system through brachial pulse wave analysis) office BP and ambulatory BP monitoring (ABPM) data and aortic pulse wave velocity (PWV) were measured in 208 hypertensive patients. Renal organ damage was evaluated by means of the albumin to creatinine ratio and the estimated glomerular filtration rate. Results: Fifty-four patients (25.9%) were affected by renal organ damage, displaying either microalbuminuria (urinary albumin excretion ≥30 mg/g creatinine) or an estimated glomerular filtration rate (eGFR) <60 ml/min/1.73 m2. Compared to those without renal abnormalities, hypertensive patients with kidney damage had higher values of office brachial systolic BP (SBP) and pulse pressure (PP), and 24-h, daytime, and nighttime central and brachial SBP and PP. They also had a blunted nocturnal decrease in both central and brachial BP, and higher values of aortic PWV. After adjustment for age, gender, and antihypertensive treatment, only ABPM-derived BP estimates (both central and brachial) showed significant associations with the presence of renal damage. Odds ratios for central BP estimates were not significantly higher than those obtained for brachial BP. Conclusion: Compared with peripheral ABPM, cuff-based oscillometric central ABPM does not show a closer association with presence of renal organ damage in hypertensive patients. More studies, however, need to be done to better identify the role of central BP in clinical practice.
Detection of Acute Tubular Necrosis Using Blood Oxygenation Level-Dependent (BOLD) MRI
Authors: Bauer Frederic , Wald Jan , Bauer Felix Jan  , Dahlkamp Lisa Maria , Seibert Felix S. , Pagonas Nikolaos , Gedat Egbert , Babel Nina , Zidek Walter , von Bodman Christian , Noldus Joachim , Liermann Dieter , Westhoff Timm H. 
Published: December 2017

Background/Aims: To date, there is no imaging technique to assess tubular function in vivo. Blood oxygen level-dependent magnetic resonance imaging (BOLD MRI) measures tissue oxygenation based on the transverse relaxation rate (R2*). The present study investigates whether BOLD MRI can assess tubular function using a tubule-specific pharmacological maneuver. Methods: Cross sectional study with 28 participants including 9 subjects with ATN-induced acute kidney injury (AKI), 9 healthy controls, and 10 subjects with nephron sparing tumor resection (NSS) with clamping of the renal artery serving as a model of ischemia/reperfusion (I/R)-induced subclinical ATN (median clamping time 15 min, no significant decrease of eGFR, p=0.14). BOLD MRI was performed before and 5, 7, and 10 min after intravenous administration of 40 mg furosemide. Results: Urinary neutrophil gelatinase-associated lipocalin was significantly higher in ATN-induced AKI and NSS subjects than in healthy controls (p=0.03 and p=0.01, respectively). Before administration of furosemide, absolute medullary R2*, cortical R2*, and medullary/cortical R2* ratio did not significantly differ between ATN-induced AKI vs. healthy controls and between NSS-I/R vs. contralateral healthy kidneys (p>0.05 each). Furosemide led to a significant decrease in the medullary and cortical R2* of healthy subjects and NSS contralateral kidneys (p<0.05 each), whereas there was no significant change of R2* in ATN-induced AKI and the NSS-I/R kidneys (p>0.05 each). Conclusion: BOLD-MRI is able to detect even mild tubular injury but necessitates a tubule-specific pharmacological maneuver, e.g. blocking the Na+-K+-2Cl- transporter by furosemide.
Fibrocytes Ameliorate Acute Lung Injury by Decreasing Inflammatory Cytokine and Chemokine Levels and Reducing Neutrophil Accumulation in the Lung
Authors: Tai Wenlin , Xu Yiheng , Ding Jiawei , Wu Hanxin , Du Ming , Qu Xiaoyuan , Gao Ling , Li Jinyu , Dong Zhaoxing
Published: December 2017

Background/Aims: Acute lung injury (ALI) remains a severe disease that threatens human life around the world. To decrease the mortality of ALI and improve ALI treatment efficacy, the development of more ALI treatments is urgently needed. Whether fibrocytes directly participate in ALI has not been studied. Therefore, a mouse model of ALI was induced with lipopolysaccharide (LPS). Methods: Fibrocytes were harvested from peripheral blood mononuclear cells of bleomycin mice and identified by using flow cytometry to detect the expression of molecular makers. The fibrocytes were injected for the treatment of acute lung injury mice. The curative effects were evaluated by using ELISA to determine the cytokines (including TNF-α, IL-6 and IFN-γ) concentrations in bronchoalveolar lavage fluid (BALF) supernatant. Results: The concentrations of cytokines such as tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), and interferon-γ (IFN-γ) were increased in mice with ALI induced with LPS. The concentrations of TNF-α, IL-6, and IFN-γ as well as their mRNA and protein expression levels were decreased by administration of fibrocytes. The effect of fibrocytes in ameliorating ALI was time dependent. LPS treatment induced an increase in myeloperoxidase (MPO) activity, whereas the fibrocyte treatment caused inhibition of MPO activity as well as expression of the neutrophil-chemoattractant chemokine macrophage inflammatory protein 2 (MIP-2). Conclusion: Taken together, these data suggest that fibrocytes ameliorated ALI by suppressing inflammatory cytokines and chemokines as well as by decreasing the accumulation of neutrophils in the lung.
Small carnivores of the montane forests of Eravikulam National Park in the Western Ghats, India
Authors: Nikhil S. , Nameer P. O.
Published: November 2017

The study of small carnivores of the montane forests of Eravikulam National Park in the southern Western Ghats, India recorded nine species of small carnivores using the camera trapping technique.  These include three species of Mongoose (Herpestidae), two species each of lesser cats (Felidae) and civets (Viverridae), one species each of Otter and Marten (Mustelidae).  They are Stripe-necked Mongoose Herpestes vitticollis, Brown Mongoose Herpestes fuscus, Indian Grey Mongoose Herpestes edwardsii, Jungle Cat Felis chaus, Leopard Cat Prionailurus bengalensis, Common Palm Civet Paradoxurus hermaphrodites, Small Indian Civet Viverricula indica, Asian Small-clawed Otter Aonyx cinereus, and Nilgiri Marten Martes gwatkinsii.  It is interesting to note that the felines (lesser cats) are the more common small carnivores in the montane forests. Felis chaus was the most abundant small carnivore, which is followed by Prionailurus bengalensis and Herpestes vitticollis.  Two species are Vulnerable as per the IUCN Red List, viz., Martes gwatkinsii and Aonyx cinereus.
Population size, herd structure and sex ratio of the Blackbuck Antilope Cervicapra (Mammalia: Cetartiodactyla: Bovidae) in a human dominated area in Odisha, India
Authors: Debata Subrat
Published: November 2017

Blackbuck Antilope cervicapra in human dominated landscapes are vulnerable to poaching, habitat loss and competition with livestock for forage.  I estimated population sizes and age structure of Blackbucks in an unprotected site of 61.21km² in Odisha over a period of one year (October 2012 to October 2013).  A total of 7,134 individuals in 366 herds were documented ranging from a single individual to the largest herd of 51 animals.  Average herd size was 19.49±0.03 (SE) and ranged from 13.34±0.06 in summer to 31.86±0.07 during the monsoon.  Sex ratio was skewed towards females by 3:1.  The young constituted 16% of the population.  This indicates that a healthy population of blackbuck is surviving in this area; therefore measures need to be taken to conserve this site and manage the area as a Blackbuck reserve.
Flies matter: a study of the diversity of Diptera families (Insecta: Diptera) of Mumbai Metropolitan Region, Maharashtra, India, and notes on their ecological roles
Authors: Dhamorikar Aniruddha H
Published: November 2017

Diptera is one of the three largest insect orders, encompassing insects commonly known as ‘true flies’.  They are one of the most important in terms of their interactions with humans.  Family-level diversity of Diptera was studied in the Mumbai Metropolitan Region (MMR)—50 families were recorded in four protected areas—Sanjay Gandhi National Park, Tungareshwar Wildlife Sanctuary, Karnala Bird Sanctuary, and Matheran Eco-Sensitive Zone, of which 24 were also found in urban areas of Mumbai and Thane City.  The MMR’s family-level dipteran diversity constitutes 78% of families documented in the Western Ghats and 57% of India’s known families of Diptera.  The recorded Diptera families were segregated into two groups based on their habits - beneficial and pestiferous.  Of the 50 families, 66% comprised members which were beneficial in terms of flower visitations (28%), decomposition (24%), and predators and parasitoids of pest insects (14%), whereas 34% comprised members that were pestiferous in nature in terms of posing a threat to human health and causing nuisance (11%), causing crop and food damage (12%), posing a threat to animal health (8%), and as parasitoids of beneficial insects (3%).  In terms of their feeding preferences, the majority of the adults were flower visitors (26%), 24% were saprophagous, followed by members that were frugivorous, fungivorous, coprophagous, and predatory in nature.  Among larval feeding habits, 31% were detritivorous, 18% phytophagous, and 13% predatory in nature.  In terms of their habitat preferences, 24 families were found in dense undergrowth, 12 in mountainous forests, and 11 in fruit gardens.  This study establishes that Diptera is more diverse in natural areas than urban areas, and emphasizes the need for further exploration in terms of taxonomic and ecological studies, and economic benefits vis-à-vis the losses they incur in the region.
First records of two Ginger Lilys Hedychium (Zingiberaceae) species from the Western Ghats, India
Authors: Thomas Sinjumol , Brittto Susai John , Mani Bince
Published: November 2017

Hedychium forrestii Diels and H. spicatum Sm. (Zingiberaceae) are new distribution records from the Western Ghats, India, extending their range up to southern India.  Detailed taxonomic descriptions are provided for the species along with photographs.
Detection of Artyfechinostomum sufrartyfex - a zoonotic parasite from the Small Indian Mongoose Herpestes auropunctatus (Mammalia: Carnivora: Herpestidae) in Jammu & Kashmir, India
Authors: Borkataki Sanku , Goswami Pankaj , Katoch Rajesh , Kumar Shahil , Raghuvanshi Pratiksha
Published: November 2017

The treamatode Artyfechinostomum sufrartyfex was identified from the small intestine of the Indian Mongoose and the morphological identification of the parasites was described.  The fluke A. sufrartyfex is important considering its significant zoonotic potential, and the present study highlights the first report of occurrence of the parasite in a newer wild host, the mongoose from India.
Roadkill records of Lowland Tapir Tapirus terrestris (Mammalia: Perissodactyla: Tapiridae) between kilometers 06 and 76 of highway BR-163, state of Pará, Brazil
Authors: De Freitas Marco A. , Printes Rodrigo C. , Motoyama Eric K. , Fucks Assor E. , Veríssimo Diogo
Published: November 2017

Fifteen Lowland Tapirs Tapirus terrestris were found road killed between kilometer six and 76 of the BR-163 highway, in the state of Pará, Brazil.  The findings took place during two periods, May/July 2016, and June 2017.  This highway is internationally known for its environmental impact and here we present additional evidence of its impact on the population of a threatened species.
A first record of the Smallfin Gulper Shark Centrophorus moluccensis Bleeker, 1860 (Chondrichthyes: Squaliformes: Centrophoridae) from the Andaman & Nicobar waters, Indian EEZ
Authors: Pradeep H. D. , Shirke Swapnil S. , Nashad M. , Sukham Monalisha Devi
Published: November 2017

The Smallfin Gulper Shark Centrophorus moluccensis is reported for the first time from the Andaman & Nicobar waters of the Indian EEZ.  A male specimen of 785mm total length and weighing 2.34kg was landed by a motorized longliner at Burmanallah, South Andaman District.  The specimen was caught off Chidiyatapu, South Andaman at a depth of 250m.  A detailed morphological description of the specimen and comparison with previous literature is provided.
A new species of dewflower Murdannia sanjappae (Commelinaceae) from Andaman Islands, India
Authors: Naik Mudavath Chennakesavulu , Rao Boyina Ravi Prasad
Published: November 2017

Murdannia sanjappae, a new species of dewflower plant of the dayflower family from Rutland Island, South Andaman Islands, India, is described and illustrated.  This novel species is similar to M. tenuissima in not having any staminodes, but differs from it by having oblong-lanceolate leaves with cordate base, distinct peduncle, pedicel with 2–3 articulations, ovate petals, and 24–30-seeded capsules.
An extended distribution of Natesh’s Cape-pondweed Aponogeton nateshii (Aponogetonaceae), a new record to the state of Goa
Authors: Kolte Rutuja Rajendra , Deshpande Anup Satish , Pillai Prabha Muraleedharan , Yadav Shrirang Ramchandra
Published: November 2017

Aponogeton nateshii, a recently described species from Ratnagiri District of Maharashtra and also recorded from Belagavi District of Karnataka is now reported from the state of Goa for the first time.  This species is highly variable in habitat preference, leaf morphology and embryo appendages.
Taxonomic revision of the genus Atmetonychus (Coleoptera: Curculionidae: Entiminae) from the Indian subcontinent
Authors: Mahendiran G. , Ramamurthy V. V.
Published: November 2017

Genus Atmetonychus Schoenherr (1840) known from India and Bangladesh is revised.  The generic and species description has been updated through addition of measurements, description of elytral vestiture and genitalic characters. These are supported by 28 illustrations including 21 line diagrams.
First record of Bourret’s Horseshoe Bat Rhinolophus paradoxolophus (Mammalia: Chiroptera: Rhinolophidae) from Myanmar with a review of the taxonomy, distribution and ecology of the species
Authors: Lin Oo Sai Sein , No Du Sar , Nang Seng Lucia , Lwin Ngwe , Pearch Malcolm , Bates Paul J.J.
Published: November 2017

Two specimens of Bourret’s Horseshoe Bat, Rhinolophus paradoxolophus, were recently collected from near Kalaw, western Shan State, Myanmar.  They represent the first country record of the species as well as a considerable western range extension.  A brief discussion of the taxonomic history of R. paradoxolophus is included along with a summary of its known ecology.  The distribution is mapped and shows a correlation with areas of limestone karst.
Requisite for long term studies in ecology
Authors: Ramanan S. Suresh
Published: November 2017

Book review: Requisite for long term studies in ecology
Maximus Confessor’s Interpretation of Abraham’s Hospitality in Genesis 18 and the Preceding Orthodox Tradition
Authors: Benevich Grigory
Published: December 2017

In Orthodox exegesis, there are two main interpretations of God’s theophany to Abraham in Gen 18: the three ‘men’ were either the pre-incarnate Christ and two angels, or, later, they were a type of the Trinity. This article deals with Maximus the Confessor’s exegesis of this passage. His interpretations are treated in the context of his teaching on love, his philosophical ideas and his mystical teaching. It shows that Maximus’ exegesis can be understood as a creative synthesis of the preceding Orthodox tradition’s two interpretations.
Three Love Stories, Three Caves, Three Suicides
Authors: Kritzinger Jacobus P.K.
Published: December 2017

In her commentary on Jerome’s Vita Malchi, in the section called ‘Literary form and texture’ Gray discusses the existing literature on which Jerome drew in composing Vita Malchi. She provides a detailed account of the sources and possible influences on Jerome under the headings Christian literature, biblical quotations and allusions, and secular literature. In a previous article, I have indicated multiple references and allusions to both classical sources and the Bible in this work of St Jerome. In this article the focus falls on a possible allusion to the story of Pyramus and Thisbe, a source which has not previously been considered amongst the possible influences on Vita Malchi. The love stories of Aeneas and Dido and Pyramus and Thisbe are compared to and contrasted with the story of Malchus and his ‘wife’.
In Terram Visionis
Authors: Makarov Dmitry I.
Published: December 2017

In his Transfiguration homily (ca. 1315) Nicephorus Choumnus, a pre-Palamite thinker, put forward a theory that Abraham at the oak of Mamre was granted the vision of the Trinity. This is the third type of the exegesis of Genesis 18, according to Lars Thunberg. By comparison with: (a) Gregory of Nyssa and other patristic authors; (b) the early second-century Testament of Abraham (TA) we have put forward a hypothesis that Abraham, in Choumnus’ view, was granted the vision of the divine light and glory, most likely, in the form of a bright cloud very similar to that which later overshadowed the elected of the prophets and the Apostles on Mount Tabor. Thus, Nicephorus Choumnus mentioned Abraham together with such symbolic OT figures, as Moses and Elijah, who had also the honor of seeing the Face of God on Tabor.
The Simultaneity of Compliance and Resistance (既顺从又抗爭：佛教、虛雲與五十年代的中共政权)
Authors: Ip Hung-yok
Published: December 2017

To examine the history of Chinese Buddhism in the early Communist regime, I propose to study Xuyun (虛雲, 1840–1958), one of the pre-eminent monks in modern China. I will delineate the ways in which Xuyun brought his religion in line with Marxist politics. To help Buddhism secure a place in the early People’s Republic of China, he took part in the construction of a new Buddhism compatible with socialist ideology. However, I would venture to conceptualize as resistance some of Xuyun’s efforts to preserve Buddhism. This article examines his resistance at two levels. First, while working hard to prove the value of Buddhism to the state, Xuyun mounted what can be regarded as rightful resistance. When possible, he confronted policies and authorities that hurt the sangha, but did so without challenging the legitimacy of theccp. Second, in the 1950s, Xuyun strove to instruct Chinese Buddhists in self-cultivation. As he shared his experience and knowledge about spiritual practice with fellow Buddhists, he showed them, especially monastics, how to uphold Buddhist ideals in a political context marked by hostility towards religions.

為了探究五十年代中共政權下的佛教歷史，本文探討現代中國最傑出的法師之一，虛雲法師 (1840–1958) 如何調整自己的宗教来適應馬克思主義政權。為了使佛教能夠在新中國成立之初生存，虛雲法師參與了構建與社會主義意識形態相適應的新佛教。但是，本文進一步嘗試把虛雲法師保存佛教的一些努力定義為抗爭，細究他在如下兩個方面的反抗：首先，在向國家證明佛教價值的同時，虛雲始終在正當性的名義下進行抗爭。在不挑戰中共政權合法性的前提下，他試圖抵抗對僧團不利的政策和政治權威。其次，虛雲法師在50年代堅持延續佛教、特别是禪宗的修行傳統。他希望佛門弟子，尤其是僧人，能在反宗教的政治氣候下繼續延續佛教的理念—这，對虛雲而言，是更重要的抗爭。
CT Study of the Arytenoid Cartilage in Patients with Laryngeal Contact Granuloma
Authors: Li Jinrang , Tian Shiyu , Zou Shizhen , Wang Qingjun , Tai Xuhui , Chen Xuesong
Published: December 2017

Objective

To explore high‐resolution computed tomography (HRCT) characteristics of arytenoid cartilage in patients with laryngeal contact granuloma (LCG).

Setting

Tertiary hospitals.

Study Design

Individual case‐control study.

Methods

HRCT scans were obtained before treatment from 42 patients with LCG. Similar scans were obtained from 50 patients with glottic laryngeal cancer or vocal cord leukoplakia without vocal process involvement.

Results

Forty‐two male patients with LCG were enrolled in the study. There were 41 patients with unilateral vocal cord lesions, and 1 patient had bilateral lesions. All 50 eligible patients in the laryngeal lesion group were men. There were 39 patients with unilateral lesions, and 11 had bilateral lesions. The rate of arytenoid cartilage sclerosis in the LCG group was 79.07% (34/43) on the lesion side and 7.32% (3/41) on the healthy side. In the laryngeal lesion group, the rate of arytenoid cartilage sclerosis was 13.11% (8/61) on the lesion side and 2.56% (1/39) on the healthy side. The rate of arytenoid cartilage sclerosis on the lesion side of patients with LCG was significantly higher than on the healthy side of patients with LCG and significantly higher than both the healthy and lesion sides of patients with laryngeal lesions (P <. 001).

Conclusions

Arytenoid cartilage sclerosis was observed on the lesion side in most patients with LCG, and the presence of sclerosis may support the diagnosis of LCG.
Chemographic exploration of the hyalotekite structure-type
Authors: Hawthorne Frank C. , Sokolova Elena , Agakhanov Atali A. , Pautov Leonid A. , Karpenko Vladimir Yu. , Grew Edward S.
Published: November 2017

The hyalotekite group has been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (memorandum 57–SM/16). The general formula of the minerals of the hyalotekite group may be written as: A2B2M2[Si8T4O28]W where A = Ba2+, Pb2+ or K+; B = Ba2+, Pb2+ or K+; M = Ca2+, Y3+ or REE3+; T = Si4+, B3+ or Be2+; and W = F– or □ (where REE = rare-earth elements and □ = vacancy).

Four minerals are currently known in this group: hyalotekite, Ba4Ca2[Si8B2(SiB)O28]F, triclinic, I$\bar 1$; khvorovite, Pb2+4Ca2[Si8B2(SiB)O28]F, triclinic I$\bar 1$; kapitsaite-(Y), Ba4(YCa)[Si8B2B2O28]F, triclinic, I$\bar 1$; and itsiite Ba4Ca2[Si8B4O28]□, tetragonal, I$\bar 4$2m.

We explore the possible end-member compositions within this group by conflating the properties of an end-member with the stoichiometry imposed by the bond topology of the hyalotekite structure-type and the crystal-chemical properties of its known constituents. There are two high-coordination sites in the hyalotekite structure, A and B, and occupancy of each of these sites can be determined only by crystal-structure refinement. If these two sites are considered together, there are 19 end-member compositions of the triclinic structure and six end-member compositions of the tetragonal structure involving A and B = Ba2+, Pb2+, K+; M = Ca2+, Y3+, REE3+; and T = Si4+, B3+, Be2+. There is the possibility for many other hyalotekite-group minerals, and two potential new minerals have been identified from data in the literature.
The fingerprint of imperial topaz from Ouro Preto region (Minas Gerais state, Brazil) based on cathodoluminescence properties and composition
Authors: Gauzzi Teodoro , Graça Leonardo Martins , Lagoeiro Leonardo , de Castro Mendes Isolda , Queiroga Gláucia Nascimento
Published: November 2017

A study of the cathodoluminescence (CL) properties of imperial topaz from Ouro Preto region (Minas Gerais state, Brazil) and its relation with trace-element composition was conducted, using scanning electron microscope cathodoluminescence (SEM-CL), optical microscope cathodoluminescence (OM-CL), cathodoluminescence-spectrometry (CL-spectrometry), electron microprobe analysis (EMPA), laser ablation inductively-coupled plasma mass spectrometry (LA-ICP-MS) and Raman spectrometry. Each analytical technique allowed characterization of the imperial topaz fingerprint. SEM-CL panchromatic images show different crystal growth and resorption events in imperial topaz crystals. Colour CL images indicate only blue to violet emissions. The CL-spectra indicate a broad emission band with low intensity peak at ~417 nm and a broad emission band with high intensity and major peaks at 685, 698, 711 and 733 nm. The EMPA indicates high OH content, in which the OH/(OH + F) ratio ranges between 0.35–0.43 (0.72 ≤ OH ≤ 0.86 apfu). High Cu and Zn concentrations (LA-ICP-MS) were measured in the high luminescence areas of SEM-CL images, suggesting both elements as CL-activators in imperial topaz. Raman and CL-spectra indicate high Cr concentrations, corroborated by EMPA and LA-ICP-MS results. The high Cr caused strong luminescence intensities that enabled their superimposition over the OH stretching mode (~3650 cm–1) of topaz in all Raman spectra. Among trace elements, the concentrations of Ti, V, Cr, Mn, Fe, Cu, Zn, Ga and Ge provide the fingerprint of imperial topaz.
Redefinition of satimolite
Authors: Pekov Igor V. , Zubkova Natalia V. , Ksenofontov Dmitry A. , Chukanov Nikita V. , Yapaskurt Vasiliy O. , Korotchenkova Oksana V. , Chaikovskiy Ilya I. , Bocharov Vladimir M. , Britvin Sergey N. , Pushcharovsky Dmitry Yu.
Published: November 2017

The borate mineral satimolite, which was first described in 1969 and remained poorly-studied until now, has been re-investigated (electron microprobe analysis, single-crystal and powder X-ray diffraction studies, crystal-structure determination, infrared spectroscopy) and redefined based on the novel data obtained for the holotype material from the Satimola salt dome and a recently found sample from the Chelkar salt dome, both in North Caspian Region, Western Kazakhstan. The revised idealized formula of satimolite is KNa2(Al5Mg2)[B12O18(OH)12](OH)6Cl4·4H2O (Z = 3). The mineral is trigonal, space group R$\bar{3}$m, unit-cell parameters are: a = 15.1431(8), c = 14.4558(14) Å and V = 2870.8(4) Å3 (Satimola) and a = 15.1406(4), c = 14.3794(9) Å and V = 2854.7(2) Å3 (Chelkar). The crystal system and unit-cell parameters are quite different from those reported previously. The crystal structure of the sample from Chelkar was solved based on single-crystal data (direct methods, R = 0.0814) and the structure of the holotype from Satimola was refined on a powder sample by the Rietveld method (Rp = 0.0563, Rwp = 0.0761 and Rall = 0.0667). The structure of satimolite is unique for minerals. It contains 12-membered borate rings [B12O18(OH)12] in which BO3 triangles alternate with BO2(OH)2 tetrahedra sharing common vertices, and octahedral clusters [M7O6(OH)18] with M = Al5Mg2 in the ideal case, with sharing of corners between rings and clusters to form a three-dimensional heteropolyhedral framework. Each borate ring is connected with six octahedral clusters: three under the ring and three over the ring. Large ellipsoidal cages in the framework host Na and K cations, Cl anions and H2O molecules.
Kenoplumbomicrolite, (Pb,□)2Ta2O6[□,(OH),O], a new mineral from Ploskaya, Kola Peninsula, Russia
Authors: Atencio Daniel , Andrade Marcelo B. , Bindi Luca , Bonazzi Paola , Zoppi Matteo , Stanley Chris J. , Kristiansen Roy
Published: November 2017

This study presents a complete characterization of kenoplumbomicrolite, (Pb,□)2Ta2O6[□,(OH),O], occurring in an amazonite pegmatite from Ploskaya Mountain, Western Keivy Massif, Kola Peninsula, Murmanskaja Oblast, Northern Region, Russia.

Kenoplumbomicrolite occurs in yellowish brown octahedral, cuboctahedral and massive crystals, up to 20 cm, has a white streak, a greasy lustre and is translucent. The Mohs hardness is ~6. Attempts to measure density (7.310–7.832 g/cm3) were affected by the ubiquitous presence of uraninite inclusions. Reflectance values were measured in air and immersed in oil. Kenoplumbocrolite is optically isotropic. The empirical formula is (Pb1.30□0.30Ca0.29Na0.08U0.03)Σ2.00(Ta0.82Nb0.62Si0.23Sn4+0.15Ti0.07Fe3+0.10Al0.01)Σ2.00O6[□0.52(OH)0.25O0.23]Σ1.00 (from the crystal used for the structural study) and (Pb1.33□0.66Mn0.01)Σ2.00(Ta0.87Nb0.72Sn4+0.18Fe3+0.11W0.08Ti0.04)Σ2.00O6[□0.80(OH)0.10O0.10]Σ1.00 (average including additional fragments). The mineral is cubic, space group Fd$\overline 3 $m. The unit-cell parameters refined from powder X-ray diffraction data are a = 10.575(2) Å and V = 1182.6(8) Å3, which are in accord with those obtained previously from a single crystal of a = 10.571(1) Å, V = 1181.3(2) Å3 and Z = 8. The mineral description and its name have been approved by the Commission on New Minerals, Nomenclature and Classification of the International Mineralogical Association (IMA2015-007a).
Survival of Staphylococcus epidermidis in Propofol and Intralipid in the Dead Space of Intravenous Injection Ports
Authors: Noble Ronan M. N. , Salim Saad Y. , Walker Bradley , Khadaroo Rachel G. , Chiarella Angelo B. , Gragasin Ferrante S. , Bourque Stephane L.
Published: December 2017

We tested whether propofol or Intralipid inoculated with Staphylococcus epidermidis would promote bacterial growth within an intravenous (IV) injection hub, a site prone to bacterial contamination. In tubes incubated under optimal conditions, S epidermidis exhibited growth in Intralipid, but not in propofol. In contrast, within the IV hub incubated with either propofol or intralipid at room temperature, S epidermidis bacterial numbers declined with time, and virtually no contamination remained after 12 hours. These data suggest that certain IV lines are inhospitable for S epidermidis.
Mental Nerve Blocks for Lip Brachytherapy: A Case Report
Authors: Hafez Osama , Ackerman Robert S. , Evans Trip , Patel Sephalie Y. , Padalia Devang M.
Published: December 2017

High dose rate interstitial brachytherapy is a commonly performed procedure for carcinoma of the lower lip. Placement of the brachytherapy catheters can be painful and may require monitored anesthesia care or general anesthesia. We present the use of bilateral mental nerve blocks with minimal sedation to facilitate placement of brachytherapy catheters.
Κρίση αντιπροσώπευσης και Δημοκρατία
Authors: Μπαλιάς Στάθης
Published: December 2017

Δεν διατίθεται περίληψη στα ελληνικά
Variances in the development of justice: com parative analysis of the leading Western court systems
Authors: Наквакина Екатерина , Nakvakina Yekatyerina
Published: December 2017

The article deals with the problem of differences in the structure and functioning of court systems in the certain countries. Examples of these differences trace to the Ancient and Medieval history. Some model of explanation is proposed. Differences and interpretation of them are demonstrated concerning the contemporary court systems of the leading Western countries, including Great Britain, France, the USA, Germany, Scandinavian countries. The author concludes that reception of this or that foreign experience concerning Russian court system must be very carefully based upon full comparativist analysis touching not only comparative law, but comparative state studying and comparative political science.
ON ONE-SIDED (B;C)-INVERSES OF ARBITRARY MATRICES
Authors: Benitez Julio , Boasso Enrico , Jin Hongwei
Published: November 2017

In this article, one-sided $(b, c)$-inverses of arbitrary matrices as well as one-sided inverses along a (not necessarily square) matrix, will be studied. In addition, the $(b, c)$-inverse and the inverse along an element will be also researched in the context of rectangular matrices.
Selling food in clear packages: The development of cellophane and the expansion of self-service merchandising in the United States, 1920s–1950s
Authors: Hisano Ai
Published: November 2017

This article examines how the increasing use of transparent packaging, specifically cellophane, and a new self-service merchandising system altered consumers’ sensory experiences in food purchasing. It focuses on the American food industry roughly from the 1920s to the 1950s, a time when self-service became the dominant way of selling perishable items in the country. Clear packages provided consumers with a new way of understanding product quality. At supermarkets, where meat was already cut and bread packaged, and where consumers rarely had a chance to actually taste, smell or touch foods, they needed to rely mostly on visual information in selecting products. Businesses’ effort to capture consumer desire facilitated the creation of a new kind of visual regime, which rested on commercial intent, gendered narratives and technological manipulation, in the rise of consumer capitalism from the early twentieth century. By emphasizing the significance of colour in food consumption, retailers created food products and store interiors intended to stimulate female consumers’ chromatic sensation and their appetite for food purchasing.
Permitted and pure: Packaged halal snack food from Southwest China
Authors: Brose Michael C.
Published: November 2017

China is home to ten groups of Muslims comprising at least twenty million people. The largest of these groups, the Chinese Muslim Hui people, have benefitted from China’s rapid economic growth in the past three decades just like their non-Muslim fellow citizens. Along with the highly visible new mosques being built in Hui communities across China, Hui economic vitality is noticeable in the burgeoning halal food industry, from five-star restaurants to street kiosks, special sections in supermarkets devoted to halal products and most recently in the e-commerce market. This article examines the packaging of halal beef jerky produced and marketed specifically for that e-commerce market, as an example of the religious, social and economic vitality of Hui in Yunnan Province in southwestern China in the post-Mao era. The packages adhere to successful strategies employed by marketing designers, and they purposefully combine faith-based and traditional Chinese cultural themes and motifs with the kind of detailed product information and quality certification demanded by consumers in China and around the world who want quality food products that might also bring a sense of nostalgia, and have the disposable income to buy those products in online shopping venues.
Telling stories: The role of graphic design and branding in the creation of ‘authenticity’ within food packaging
Authors: Barnes Alison
Published: November 2017

Food is increasingly sold with a story, and the majority of those writing about the branding process within industry agree that this story should be ‘authentic’; a ‘true’ representation of a brand’s value or personality. Across the broader field of branding, ‘authenticity’ has become key to a product’s marketing. However, much of the language used to describe and market food is very difficult to define or standardize – terms such as ‘local’, ‘quality’, ‘authentic’ and ‘premium’ remain confusing for the customer. Furthermore, in the context of branding and marketing, multiple genres of authenticity have been defined. Therefore, the food and design industries can use this lack of clarity to their advantage, emphasizing and embellishing some aspects of a product, and perhaps even deliberately omitting others. In doing so, they develop the narrative that will best connect with their audience. In this sense, the ‘authenticity’ of the brand or product is interpreted through this interaction and can be framed as a social construction. These issues are discussed in the context of a short UK-based case study focusing on the supermarket Tesco’s ‘fake farm’ brands that utilize the design and branding of the packaging to evoke specific aspects of ‘authenticity’. The visual material is analysed using a social semiotic approach enabling a discussion of issues relating to the communication of ‘authenticity’ in the practice of graphic design and branding, and the marketing of food with a story.
Nudging food into a healthy direction: The effects of front-of-pack implicit visual cues on food choice
Authors: Coulthard Stephanie , Hooge Ignace , Smeets Monique , Zandstra Elizabeth
Published: November 2017

This study investigated the effects of implicit visual cues on food package design on visual attention and subsequent decision-making. Forty-two participants chose between two target or two filler products while their eye movements were measured with eye tracking. Target stimuli were identical soups with labels varying in shape, angularity and orientation inserted at the top right of the packages. Results showed that packages with upward-rounded labels were chosen most often, followed by downward-rounded, upward-angular and downward-angular labels. Participants looked at both packages for 85 per cent of the time, whereas the labels were only fixated on for 14.8 per cent of the time. Hence, people did not necessarily look at the labels in order to make a decision about which product to choose. This research showed that differently shaped labels affected subsequent decision-making when implemented in the peripheral parts of product packs. Interestingly, there was a general preference bias for upward-rounded labels on front of pack. Therefore, presenting upward-rounded labels peripheral on pack may serve as a useful nudge to actively guide people’s behaviour towards a healthier direction.
Creation as a method of enquiry: Reflections on practice-based research in children’s picturebook illustration
Authors: Little Laura
Published: November 2017

While practice-based research is a relatively new area of research in the United Kingdom, it is growing rapidly. The theoretical frameworks that underpin practice-based research are broad, which can result in anxiety or confusion in students who undertake it. This article explores frameworks for practice-based research and considers some applications of these frameworks to a research project in children’s picturebook illustration. One challenge of practice-based research is a perceived gap between creation and interpretation. Chris Rust’s findings for the AHRC report on practice-based research, for example, highlight tensions between the discourses of the practitioner and the theorist. While there is a significant body of literature on children’s picturebooks, academic work by illustrators and artists that focuses on the processes rather than on the finished picturebook is currently underrepresented. The research described here aims to build on existing literature to offer insights from a picturebook maker’s perspective into the often-undisclosed thought processes underlying his or her work. It demonstrates the possibility for the practitioner to take an interdisciplinary approach to practice-based research in picturebooks and offers an accessible framework to explore and discuss practical work.