bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 Booster Vaccine Intention by Health Care Workers in Jakarta, Indonesia: Using the Extended Model of Health Behavior Theories
Authors: Maria Suzy , Pelupessy Dicky C. , Koesnoe Sukamto , Yunihastuti Evy , Handayani Dwi Oktavia T. L. , Siddiq Tommy Hariman , Mulyantini Astri , Halim Ahmad Rhyza Vertando , Wahyuningsih Endang Sri , Widhani Alvina , Awanis Ghina Shabrina , Muda Maulana Girsang , Karjadi Teguh Harjono , Hasibuan Anshari Saifuddin , Rengganis Iris , Djauzi Samsuridjal
Published: October 2022

In Indonesia, COVID-19 vaccination hesitancy persists among health care workers (HCWs). Understanding the motives and challenges impacting HCWs’ acceptance of the booster vaccination is critical. Efforts are still needed to overcome apprehension about taking a booster dosage. This study aims to analyze the vaccine acceptance among HCWs in Jakarta using an extended, modified model of health behavior theories, namely The Health Belief Model (HBM) and The Theory of Planned Behavior (TPB). A cross-sectional survey from November 2021 to January 2022 was distributed to health care workers in Jakarta. Bivariate analysis followed by multivariate regression was used to assess factors associated with the vaccine intention and collected 1684 responses. The results have shown that the final model combining the constructs and demographic characteristics could explain 50% of the variance of intention to receive a COVID-19 booster vaccination. Moreover, anticipated regret had the most significant standardized coefficient among the constructs (β = 0.381, p < 0.001). Other significant predictors in the model were attitude (β = 0.243, p < 0.001), perceived benefits (β = 0.103, p < 0.001), subjective norms (β = 0.08, p = 0.005), and perceived susceptibility (β = 0.051, p = 0.016). The findings can be used to strategize interventions to increase vaccine uptake.
Transcriptional Biomarkers for Treatment Monitoring of Pulmonary Drug-Resistant Tuberculosis: Protocol for a Prospective Observational Study in Indonesia
Authors: Parwati Ida , Pitaloka Dian Ayu Eka , Chaidir Lidya
Published: October 2022

Many blood-based gene expression biomarkers for monitoring tuberculosis (TB) treatment have been suggested so far, but promising biomarker results for drug-resistant TB treatment response have not been studied. This protocol presents a prospective observational study in Indonesia to profile the human blood transcriptome for predicting the response to drug-resistant TB treatment, focusing on pulmonary TB, and to adapt the specific RNA signature to the qRT-PCR platform. Longitudinal blood samples will be collected from 44 subjects with rifampicin resistant TB, confirmed by Xpert MTB/RIF, and 52 healthy controls. RNA-Seq will be performed to identify changes in the transcriptome following TB treatment. A discriminative RNA signature will be chosen and translated into a score for use in a quantitative PCR-based assay. This study will provide crucial information to guide the discovery and design of a clinically implementable tool to monitor the response of TB treatment.
The Brahmavarta Initiative: A Roadmap for the First Self-Sustaining City-State on Mars
Authors: Mukundan Arvind , Wang Hsiang-Chen
Published: October 2022

The vast universe, from its unfathomable ends to our very own Milky Way galaxy, is comprised of numerous celestial bodies—disparate yet each having their uniqueness. Amongst these bodies exist only a handful that have an environment that can nurture and sustain life. The Homo sapiens species has inhabited the planet, which is positioned in a precise way—Earth. It is an irrefutable truth that the planet Earth has provided us with all necessities for survival—for the human race to flourish and prosper and make scientific and technological advancements. Humans have always had an innate ardor for exploration—and now, since they have explored every nook and corner of this planet, inhabiting it and utilizing its resources, the time has come to alleviate the burden we have placed upon Earth to be the sole life-sustaining planet. With limited resources in our grasp and an ever-proliferating population, it is the need of the hour that we take a leap and go beyond the planet for inhabitation—explore the other celestial objects in our galaxy. Then, however, there arises a confounding conundrum—where do we go? The answer is right next to our home—the Red Planet, Mars. Space scientists have confirmed that Mars has conditions to support life and is the closest candidate for human inhabitation. The planet has certain similarities to Earth and its proximity provides us with convenient contact. This paper will be dealing with the conceptual design for the first city-state on Mars. Aggregating assumptions, research, and estimations, this first settlement project shall propose the most optimal means to explore, inhabit and colonize our sister planet, Mars.
Clinical Experience with a Medical Device Containing Xyloglucan, Hibiscus, and Propolis for the Control of Acute Uncomplicated Urinary Tract Infection-like Symptoms
Authors: Ortega Patricia , Benito Esther , Berrocal Félix
Published: October 2022

Background: The development of drug resistance among causative agents has resulted in the need to change the paradigm toward alternative therapeutic approaches for uncomplicated urinary tract infections (UTIs). The objective of the present study was to evaluate the efficacy of an oral medical device containing xyloglucan, hibiscus, and propolis in clinical practice with a cohort of women from Switzerland with UTI-like symptoms and the administration of concomitant drugs. Materials and Methods: This work describes an observational, prospective, and multicenter study involving 103 women attending a primary care physician for a symptomatic episode, or recurrence, of acute uncomplicated cystitis between August 2018 and June 2019. Utipro®Plus was administered orally, with patients being prescribed two capsules per day for 5 days to control discomfort symptoms or one capsule per day for 15 consecutive days per month (followed by a 15-day break for a 3-month cycle) to prevent recurrences. Results: A total of 84 women (81.6%) did not require an additional consultation, whereas 17 (16.5%) required a second one. Inadequate treatment response was found in 7 women out of the 19 who required a further consultation (36.8%): 3 women with no history of cystitis (out of 13, 23.1%) and 4 with recurrent cystitis (out of 6, 66.7%). None of the women from the study reported an adverse event. Conclusions: The studied product containing xyloglucan, hibiscus, and propolis is safe and effective for the treatment of a broad spectrum of women with acute uncomplicated or recurrent UTI-like symptoms.
Drivers of Spatial Expansions of Vampire Bat Rabies in Colombia
Authors: Rojas-Sereno Zulma E. , Streicker Daniel G. , Medina-Rodríguez Andrea Tatiana , Benavides Julio A.
Published: October 2022

Spatial expansions of vampire bat-transmitted rabies (VBR) are increasing the risk of lethal infections in livestock and humans in Latin America. Identifying the drivers of these expansions could improve current approaches to surveillance and prevention. We aimed to identify if VBR spatial expansions are occurring in Colombia and test factors associated with these expansions. We analyzed 2336 VBR outbreaks in livestock reported to the National Animal Health Agency (Instituto Colombiano Agropecuario—ICA) affecting 297 municipalities from 2000–2019. The area affected by VBR changed through time and was correlated to the reported number of outbreaks each year. Consistent with spatial expansions, some municipalities reported VBR outbreaks for the first time each year and nearly half of the estimated infected area in 2010–2019 did not report outbreaks in the previous decade. However, the number of newly infected municipalities decreased between 2000–2019, suggesting decelerating spatial expansions. Municipalities infected later had lower cattle populations and were located further from the local reporting offices of the ICA. Reducing the VBR burden in Colombia requires improving vaccination coverage in both endemic and newly infected areas while improving surveillance capacity in increasingly remote areas with lower cattle populations where rabies is emerging.
Immunoinformatics Identification of the Conserved and Cross-Reactive T-Cell Epitopes of SARS-CoV-2 with Human Common Cold Coronaviruses, SARS-CoV, MERS-CoV and Live Attenuated Vaccines Presented by HLA Alleles of Indonesian Population
Authors: Gustiananda Marsia , Julietta Vivi , Hermawan Angelika , Febriana Gabriella Gita , Hermantara Rio , Kristiani Lidya , Sidhartha Elizabeth , Sutejo Richard , Agustriawan David , Andarini Sita , Parikesit Arli Aditya
Published: October 2022

Reports on T-cell cross-reactivity against SARS-CoV-2 epitopes in unexposed individuals have been linked with prior exposure to the human common cold coronaviruses (HCCCs). Several studies suggested that cross-reactive T-cells response to live attenuated vaccines (LAVs) such as BCG (Bacillus Calmette–Guérin), OPV (Oral Polio Vaccine), and MMR (measles, mumps, and rubella) can limit the development and severity of COVID-19. This study aims to identify potential cross-reactivity between SARS-CoV-2, HCCCs, and LAVs in the context of T-cell epitopes peptides presented by HLA (Human Leukocyte Antigen) alleles of the Indonesian population. SARS-CoV-2 derived T-cell epitopes were predicted using immunoinformatics tools and assessed for their conservancy, variability, and population coverage. Two fully conserved epitopes with 100% similarity and nine heterologous epitopes with identical T-cell receptor (TCR) contact residues were identified from the ORF1ab fragment of SARS-CoV-2 and all HCCCs. Cross-reactive epitopes from various proteins of SARS-CoV-2 and LAVs were also identified (15 epitopes from BCG, 7 epitopes from MMR, but none from OPV). A majority of the identified epitopes were observed to belong to ORF1ab, further suggesting the vital role of ORF1ab in the coronaviruses family and suggesting it as a candidate for a potential universal coronavirus vaccine that protects against severe disease by inducing cell mediated immunity.
Differential Homing Receptor Profiles of Lymphocytes Induced by Attenuated versus Live Plasmodium falciparum Sporozoites
Authors: Mura Marie , Atre Tanmaya , Savransky Tatyana , Bergmann-Leitner Elke S.
Published: October 2022

The onset of an adaptive immune response provides the signals required for differentiation of antigen-specific lymphocytes into effector cells and imprinting of these cells for re-circulation to the most appropriate anatomical site (i.e., homing). Lymphocyte homing is governed by the expression of tissue-specific lymphocyte homing receptors that bind to unique tissue-specific ligands on endothelial cells. In this study, a whole-parasite malaria vaccine (radiation-attenuated sporozoites (RAS)) was used as a model system to establish homing receptor signatures induced by the parasite delivered through mosquito bite to provide a benchmark of desirable homing receptors for malaria vaccine developers. This immunization regimen resulted in the priming of antigen-specific B cells and CD8+ T cells for homing primarily to the skin and T/B cell compartments of secondary lymphoid organs. Infection with live sporozoites, however, triggers the upregulation of homing receptor for the liver and the skin, demonstrating that there is a difference in the signal provided by attenuated vs. live sporozoites. This is the first report on imprinting of homing routes by Plasmodium sporozoites and, surprisingly, it also points to additional, yet to be identified, signals provided by live parasites that prime lymphocytes for homing to the liver. The data also demonstrate the utility of this method for assessing the potential of vaccine formulations to direct antigen-specific lymphocytes to the most relevant anatomical site, thus potentially impacting vaccine efficacy.
Adherence to Herpes Zoster (Shingles) Catch-Up Campaign at the Romagna Local Health Authority (Italy), a Multi-Center Retrospective Observational Study
Authors: Ceccarelli Andrea , Scrimaglia Susan , Fossi Virginia , Ceccaroni Luigi , Federici Andrea , Reali Chiara , Angelini Raffaella , Silvestrini Giulia , Sintoni Francesco , Fantini Maria Pia , Gori Davide , Righi Francesca , Montalti Marco
Published: October 2022

Herpes Zoster (shingles) is an infection that occurs when varicella-zoster virus reactivates from the latent state. Incidence and severity of Herpes Zoster disease increase with age. Antiviral drugs are the elective treatment; however, prevention of disease reactivation through effective and safe vaccines is available in Italy out-of-pocket from age 65 onwards. The Romagna Local Health Authority (northern Italy) administered catch-up vaccinations in March–May 2022 for immunizations not performed during the COVID-19 pandemic. In this study, adherence rates to the catch-up campaign and recall activities adopted in two centers were investigated. The uptakes for only the catch-up vaccinations were 11.4% and 12.4%. Having suffered from Herpes Zoster or having family members who suffered from it would not seem to be drivers of increased uptake. Although sending text-messages to all involved patients was the main motivation for vaccine uptake (85.7–95.1%), word of mouth and web/news advertising also contributed to adoption in Center No. 2. In both centers, the need for greater synergy between public health departments and general practitioners to engage their patients emerged, as did the need for additional recall measures. Studying the main drivers of vaccine hesitancy, especially at the local level, can help in targeting campaigns and catch-up activities in order to achieve widespread acceptance.
Immunotherapies for the Treatment of Drug Addiction
Authors: Hossain Md Kamal , Davidson Majid , Kypreos Erica , Feehan Jack , Muir Joshua Alexander , Nurgali Kulmira , Apostolopoulos Vasso
Published: October 2022

Substance use disorders (SUD) are a serious public health concern globally. Existing treatment platforms suffer from a lack of effectiveness. The development of immunotherapies against these substances of abuse for both prophylactic and therapeutic use has gained tremendous importance as an alternative and/or supplementary to existing therapies. Significant development has been made in this area over the last few decades. Herein, we highlight the vaccine and other biologics development strategies, preclinical, clinical updates along with challenges and future directions. Articles were searched in PubMed, ClinicalTrial.gov, and google electronic databases relevant to development, preclinical, clinical trials of nicotine, cocaine, methamphetamine, and opioid vaccines. Various new emerging vaccine development strategies for SUD were also identified through this search and discussed. A good number of vaccine candidates demonstrated promising results in preclinical and clinical phases and support the concept of developing a vaccine for SUD. However, there have been no ultimate success as yet, and there remain some challenges with a massive push to take more candidates to clinical trials for further evaluation to break the bottleneck.
Flagellin Improves the Immune Response of an Infectious Bursal Disease Virus (IBDV) Subunit Vaccine
Authors: Murtaza Asad , Afzal Haroon , Doan Thu-Dung , Ke Guan-Ming , Cheng Li-Ting
Published: October 2022

Flagellin activates the immune system through Toll-like receptor 5 (TLR5) and can work as an adjuvant for subunit vaccines. In this study, we tested the adjuvancy of two different N-terminal fragments of flagellin, (1) FliC99, residues 1–99, and (2) FliC176, residues 1–176, to incorporate larger areas of the hotspot region for potentially higher levels of TLR5 activation and immune response. A truncated version of the VP2 protein (name tVP2, residues 199–356) of the Infectious bursal disease virus (IBDV) was genetically linked to the flagellin constructs, and the immune response was evaluated in chickens. Results showed that both chimeric antigen–adjuvant constructs increased humoral (total IgG titers), cellular and cytokine immune response (IL-4, IFN-γ). The resulting antibody also successfully neutralized IBDV. We conclude that the N-terminus of flagellin can act as an immune activator to enhance vaccine efficacy.
Short-Term Adverse Effects Following Booster Dose of Inactivated-Virus vs. Adenoviral-Vector COVID-19 Vaccines in Algeria: A Cross-Sectional Study of the General Population
Authors: Lounis Mohamed , Aouissi Hani Amir , Abdelhadi Samir , Rais Mohammed Amir , Belkessa Salem , Bencherit Djihad
Published: October 2022

COVID-19 booster vaccines have been adopted in almost all countries to enhance the immune response and combat the emergence of new variants. Algeria adopted this strategy in November 2021. This study was conducted to consider the self-reported side effects of COVID-19 booster vaccines by Algerians who were vaccinated with a booster dose of one of the approved inactivated-virus vaccines, such as BBIBP-CorV and CoronaVac, or one of the adenoviral-vector-based vaccines, such as Gam-COVID-Vac, AZD1222 and Ad26.COV2.S, and to determine the eventual risk factors. A cross-sectional study using an online self-administered questionnaire (SAQ) was conducted in Algeria between 28 April 2022, and 20 July 2022. A descriptive analysis of the 196 individuals who were included showed a nearly equal distribution of adenoviral- (52%) and inactivated-virus vaccines (48%) and of males (49.5%) and females (50.5%). The results showed that 74.7% of the studied population reported at least one local or systemic side effect. These side effects were more frequent among adenoviral-vector vaccinees (87.3%) than inactivated-virus vaccinees (60.6%) (sig. < 0.001). Injection site pain (40.3%), heat at the injection site (21.4%), and arm pain (16.3%) were the most common local side effects. These signs generally appeared in the first 12 h (73.3%) and generally lasted less than 24 h (32.8%). More interestingly, these signs differed from those that followed the administration of primer doses (48.5%) and were generally more severe (37%). The same observation was reported for systemic side effects, where the signs were especially most severe in the adenoviral-vaccinated group (49.4% vs. 20.8%; sig. = 0.001). These signs generally appeared within the first day (63.6%) and mostly disappeared before two days (50.8%), with fatigue (41.8%), fever (41.3%), and headache (30.1%) being the most common. Adenoviral-vector vaccinees (62.7%) were more likely to use medications to manage these side effects than were inactivated-virus vaccinees (45.7%) (sig. = 0.035) and paracetamol (48.5%) was the most used medication. Adenoviral-based vaccines were the types of vaccines that were most likely to cause side effects. In addition, being female increased the risk of developing side effects; regular medication was associated with local side effects among inactivated-virus vaccinees; and previous infection with COVID-19 was associated with systemic and local side effects among adenovirus-based vaccinees. These results support the short-term safety of booster vaccines, as has been reported for primer doses.
Effect of Dietary Chlorogenic Acid on Growth Performance, Antioxidant Function, and Immune Response of Broiler Breeders under Immune Stress and Stocking Density Stress
Authors: Bai Dongying , Liu Kexin , He Xianglong , Tan Haiqiu , Liu Yanhao , Li Yuqian , Zhang Yi , Zhen Wenrui , Zhang Cai , Ma Yanbo
Published: October 2022

The study was conducted to evaluate the effects of dietary chlorogenic acid supplementation on the growth performance, antioxidant function, and immune response of broiler breeders exposed to immune stress or high stocking density stress. The test was divided into two stress models. For the immune stress test, 198 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) saline control (birds injected with saline and fed basal diet), (2) LPS group (birds injected with 0.5 mg LPS/kg body weight and fed basal diet), and (3) CGA + LPS group (birds injected with LPS and fed basal diet supplemented with 1 g/kg CGA. LPS was intraperitoneally injected from day 14, and then daily for 10 days. For the high stocking density stress model, 174 birds were distributed into three experimental treatments with six replicates per treatment. The treatments were: (1) controls (birds fed basal diet and raised at a stocking density of 14 broilers per m2), (2) high-density group (birds fed with basal diet and raised at a stocking density of 22 broilers per m2), and (3) high density + CGA group (birds fed with 1 g/kg CGA and raised at a stocking density of 22 broilers per m2). Results showed that LPS injection and high stocking density significantly decreased the body weight and feed intake of broiler breeders, while CGA supplementation increased feed intake of broiler breeders under LPS injection and high stocking density stress. Moreover, LPS injection and high stocking density increased the concentration of corticosterone in serum, and CGA addition remarkably downregulated serum corticosterone levels. The GSH level decreased with LPS injection and CGA increased the GSH concentration in the intestines of immune-stressed broiler breeders. LPS injection promoted the production of circulating proinflammatory cytokines (serum IL-1β and TNF-α) by 72 h after LPS injection. Dietary supplementation with CGA prevented the increase in serum TNF-α caused by LPS. These results suggest that dietary inclusion of 1 g/kg CGA could increase the feed intake of broiler breeders and alleviate the effects of inflammatory mediator stress and exposure to high stocking density.
HER2 Overexpression and Cytogenetical Patterns in Canine Mammary Carcinomas
Authors: Muscatello L. V. , Gobbo F. , Di Oto E. , Sarli G. , De Maria R. , De Leo A. , Tallini G. , Brunetti B.
Published: October 2022

Human epidermal growth factor receptor 2 (HER2) is a tyrosine kinase receptor that promotes tumor cell growth and is implicated in the pathogenesis of human breast cancer. The role of HER2 in canine mammary carcinomas (CMCs) is not clear. Therefore, this study aimed to examine the protein expression and cytogenetic changes of HER2 and their correlation with other clinical–pathological parameters in CMC. We retrospectively selected 112 CMCs. HER2, ER, and Ki67 were assessed by immunohistochemistry. HER2 antibody validation was investigated by immunoblot on mammary tumor cell lines. Fluorescence in situ hybridization (FISH) was performed with probes for HER2 and CRYBA1 (control gene present on CFA9). HER2 protein overexpression was detected in 15 carcinomas (13.5%). A total of 90 carcinomas were considered technically adequate by FISH, and 8 out of 90 CMC (10%) were HER2 amplified, 3 of which showed a cluster-type pattern. HER2 overexpression was correlated with an increased number of HER2 gene copies (p = 0.01; R = 0.24) and overall survival (p = 0.03), but no correlation with ER, Ki67, grade, metastases, and tumor-specific survival was found. Surprisingly, co-amplification or polysomy was identified in three tumors, characterized by an increased copy number of both HER2 and CRYBA1. A morphological translocation-fusion pattern was recognized in 20 carcinomas (22%), with a co-localized signal of HER2 and CRYBA1. HER2 is not associated with clinical–pathological parameters of increased malignancy in canine mammary tumors, but it is suitable for studying different amplification patterns.
Subtotal Ovariohysterectomy Following Fetal Maceration and Pyometra in a Maiden Welsh Pony Mare
Authors: Nevard Rory , Labens Raphael , Stephen Cyril P
Published: October 2022

Fetal maceration and pyometra were diagnosed in a 16-year-old maiden Welsh pony mare. Due to anatomical and surgical difficulties encountered throughout treatment, previously reported techniques including both per-vaginum removal of fetal remnants and ovariohysterectomy were attempted and resulted in novel complications. Fetal bones were unable to be removed completely transcervically due to failure of cervical dilation despite repeated attempts. Subsequent surgical complications such as inadequate exposure of the uterus and incorporation of fetal bones into the uterine stump following ovariohysterectomy also occurred. This case highlights some of the difficulties in managing rare cases of mid-term fetal loss and retention that result in maceration. Ultimately, this may provide useful insights to practitioners when managing similar cases in future.
An Overview of Transboundary Animal Diseases of Viral Origin in South Asia: What Needs to Be Done?
Authors: Gongal Gyanendra , Rahman Habibar , Thakuri Kishan Chand , Vijayalakshmy Kennady
Published: October 2022

Transboundary animal diseases (TADs) pose a serious threat to the sustainability and economic viability of the existing animal agriculture ecosystem in south Asia. The rapid spread of African swine fever and lumpy skin diseases in south Asia must be considered a wake-up call to prevent the entry, spread, and establishment of new exotic TADs, as south Asia has the highest density of livestock populations, and it will have a huge socioeconomic impact. Regional cooperation for the prevention and control of TADs is necessary, but rational decisions should be made to initiate even sub-regional cooperation in the present geopolitical situation. Cross-border collaboration for surveillance, early warnings, and animal movement control should be encouraged on a bilateral or multilateral basis as many countries share a porous border. Foot-and-mouth disease (FMD), peste des petits ruminants (PPR), and avian influenza (AI) have been identified as regional priority TADs, and many regional and country initiatives have been undertaken in the last two decades that need to be translated into action. The incursion of exotic TADs into south Asia has compelled us to rethink overall policies and strategies for prevention and control of TADs. This paper took into consideration six emerging and endemic TADs of viral origin to suggest a future course of action.
Study on Hydraulic Dampers Using a Foldable Inverted Spiral Origami Structure
Authors: Guan Jingchao , Zuo Jingshun , Zhao Wei , Gomi Nobuyuki , Zhao Xilu
Published: October 2022

Hydraulic dampers for the vibration damping of industrial machinery and building structures are typically cylindrical. This study proposes a novel, axially free-folding hydraulic damper of the origami type to improve the structural characteristics of the conventional cylinder shape with restricted effective stroke in relation to the overall length. First, the basic design equation of the proposed origami hydraulic damper was derived by demonstrating that the fold line cylinders on the sidewalls will always meet the foldable condition of the origami hydraulic damper, that is, α=π/n and π/2n≤β≤π/n. Next, the fluid flow characteristics inside the origami hydraulic damper and in the flow path were analyzed; it was determined that the actual damping force exerted on the origami damper was proportional to the square of the velocity of motion. Equations of motion were developed considering the derived damping force equation, and a vibration analysis method using the Range–Kutta numerical analysis technique was established. A validation test system with an origami hydraulic damper in a mass-spring vibration system was developed, and vibration tests were performed with actual seismic waves to verify the damping characteristics and effectiveness of the origami hydraulic damper. Furthermore, the orifice hole diameter at the end of the origami structure as well as the type of internal fluid, were varied in the vibration tests. The effect of the main components of the origami hydraulic damper on the damping effect was analyzed, revealing that the orifice hole diameter had a more significant effect than the internal fluid.
Assessing the Performance of a Novel Bayesian Algorithm at Point of Care for Red Eye Complaints
Authors: Deans Alexander M. , Basilious Amy , Hutnik Cindy M.
Published: October 2022

The current diagnostic aids for red eye are static flowcharts that do not provide dynamic, stepwise workups. The diagnostic accuracy of a novel dynamic Bayesian algorithm for red eye was tested. Fifty-seven patients with red eye were evaluated by an emergency medicine physician who completed a questionnaire about symptoms/findings (without requiring extensive slit lamp findings). An ophthalmologist then attributed an independent “gold-standard diagnosis”. The algorithm used questionnaire data to suggest a differential diagnosis. The referrer’s diagnostic accuracy was 70.2%, while the algorithm’s accuracy was 68.4%, increasing to 75.4% with the algorithm’s top two diagnoses included and 80.7% with the top three included. In urgent cases of red eye (n = 26), the referrer diagnostic accuracy was 76.9%, while the algorithm’s top diagnosis was 73.1% accurate, increasing to 84.6% (top two included) and 88.5% (top three included). The algorithm’s sensitivity for urgent cases was 76.9% (95% CI: 56–91%) using its top diagnosis, with a specificity of 93.6% (95% CI: 79–99%). This novel algorithm provides dynamic workups using clinical symptoms, and may be used as an adjunct to clinical judgement for triaging the urgency of ocular causes of red eye.
Quantização canônica do modelo de Bagger-Lambert-Gustavsson (BLG)
Authors:   , Aguiar Aruã Menezes de
Published: October 2022

O entendimento das leis fundamentais da natureza somente estará completo quando a Mecânica Quântica e a Relatividade Geral estiverem unificadas com sucesso. A Teoria das Cordas e a Teoria-M surgem como candidatas a essa unificação. Essa última relaciona todos os tipos de corda e é baseada na ideia de que existem objetos fundamentais na natureza chamados p-branas. Neste trabalho, estudou-se um modelo proposto por Bagger, Lambert e Gustavsson para um sistema de múltiplas M2-branas baseado em uma triálgebra conhecido como Modelo BLG. Efetuou-se a quantização canônica do Modelo BLG dimensionalmente reduzido utilizando o método de quantização de Dirac
Estudos surdos em destaque
Authors: Vieira Claudia Regina
Published: October 2022

Uma coletânea com 10 capítulos que circunscreve um campo de pesquisa e as discussões acerca da presença e permanência de estudantes surdos na pós graduação e principalmente sua ascensão educacional atráves das políticas públicas, conquistadas ao longo dos anos, bem como das ações educacionais, sociais, políticas e culturais da população.
Modüler A-Metrik Uzaylarda Çeşitli Tipte w-Bağdaşabilir Dönüşümler
Authors: KAPLAN Elif , KÜTÜKCÜ Servet
Published: October 2022

Bu makalede, modüler A-metrik uzaylar üzerinde w-bağdaşabilir dönüşümler, (α) tip w-bağdaşabilir dönüşümler ve (β) tip w-bağdaşabilir dönüşümler olarak adlandırdığımız üç yeni tip bağdaşabilir dönüşüm tanımladık. Bu tanımları kullanarak aralarındaki ilişkileri araştırdık. Bu makalede elde edilen sonuçlar literatürde var olan ve iyi bilinen birçok sonucu genelleştirmesidir
Role of the Collective Effects on Neutron Capture Reaction Cross Section
Authors: CANBULA Deniz
Published: October 2022

The neutron capture reaction is one of the important reactions that provides the determination of the structural properties of the nucleus and detailed information about the capture reaction mechanisms. In this study, cross section values of 89Y(n,g)90Y reaction, which is a neutron capture reaction, were calculated with TALYS computer code up to 10 MeV incident particle energy using different level density models. In the calculations, back-shifted Fermi gas model (BSFGM), constant temperature model (CTM), generalized superfluid model (GSM), and collective semi-classical Fermi gas model (CSCFGM) were preferred. The obtained results were compared with the data taken from the experimental database. In addition, the quality factors of the models were presented in the table. As a result of the calculations, it has been presented that the CSCFGM, which takes the collective effects into account basically, is more successful model to reproduce the experimental data and that the collective effects play a dominant role on the neutron capture reaction cross sections. Therefore, it has been demonstrated that CSCFGM is a model, which can be used for neutron capture reaction analyses in the future.
Suitable Location Selection for Shopping Centers by Using GIS and AHP in Adana City Center
Authors: İNCEYAVUZ Hilal , ALKAN Tansu , DURDURAN Süleyman Savaş
Published: October 2022

Alışveriş merkezleri (AVM) sağladığı rahat ve güvenilir alışveriş imkânı, birçok ihtiyacı tek bir mekândan karşılayabilme kolaylığı ve kaliteli malzemeyi donanımlı elemanlarla tüketiciye sunması açısından kullanıcılar için vazgeçilmez alanlardan biri haline gelmiştir. AVM projeleri için en önemli faktör konumdur. Perakende ticaret alanlarının sürdürülebilirliği, artan rekabet ve konumun sonradan değiştirilmesinin zorluğu açısından AVM konumunun belirlenmesinde birçok faktör birlikte değerlendirilmeli ve bilimsel yöntemlerden faydalanılmalıdır. Bu çalışmada, Adana şehir merkezinde yeni bir AVM projesi için uygun yerlerin belirlenmesi amaçlanmaktadır. Bu amaç doğrultusunda nüfusun ve yerleşimin yoğun olduğu şehir merkezi ve yakın çevresini kapsayan bir çalışma sınırı oluşturulmuştur. AVM için uygun yerlerin belirlenmesinde arazi büyüklüğü, ulaşılabilirlik ve demografik özellikler olmak üzere üç ana faktör ve on beş alt faktör belirlenmiştir. Bu faktörlerin değerlendirilmesinde Coğrafi Bilgi Sistemlerine (CBS) dayalı Çok Kriterli Karar Verme (ÇKKV) tekniklerinden biri olan Analitik Hiyerarşi Prosesi (AHP) yöntemi kullanılmıştır. AHP ile faktörlerin etki dereceleri belirlenmiş ve CBS ile her bir faktör haritalandırılmıştır. Bu haritalar çakıştırılarak sonuç haritası elde edilmiş ve uygun olan yerler değerlendirilerek karar vericilere sunulmak üzere alternatif alanlar belirlenmiştir. Bu çalışma, yatırımcılar ve karar vericiler için rehber niteliği olması açısından önem taşımaktadır.
Investigation of the Relationship Between GNSS Observation Time and Position Accuracy in Precise Point Positioning Method
Authors: ÖZBULAT Özgür , ŞAFAK YAŞAR Şeyma , TİRYAKİOĞLU İbrahim
Published: October 2022

In this research, the effect of Precise Point Positioning (PPP) method on the position accuracy of GNSS points has been investigated and 8 TUSAGA-Active points were used. In an effort to improve the GNSS position accuracy, 24-hour RINEX data was evaluated using the GAMIT/GLOBK that academic software. The 24-hour datas for each stations divided into subgroups of data with TEQC software. These subgroups of data are 2-4-6-8 and 12 hours. Then, all subgroups of data were evaluated with online-based CSRS-PPP software. By accepting the 24-hour data of GAMIT/GLOBK software as correct, the mean squared errors were calculated from the results of the data sets obtained from CSRS-PPP. Furthermore, the relationships between measurement time/positioning accuracy were determined. These results were compared with Eckl et al. 2001. The position accuracies obtained from the PPP solutions were found to be compatible with the position accuracy relations obtained in Eckl et al. (2001).
Geochemical Characteristics of the Pan-African Basement Rocks at Atud Area, Central Eastern Desert, Egypt
Authors: YILDIRIM Demet Kıran , ABDELNASSER Amr
Published: October 2022

Bu çalışmada, Atud bölgesi’ndeki (Mısır'ın Orta Doğu Çölü) Prekambriyen Pan-Afrikan temel kayaçlarının jeolojik yerleşimlerini, jeokimyasal özelliklerini, saha ilişkilerini, tektonik yerleşimlerini ve petrojenezlerini belirlemek için petrografik ve jeokimyasal özellikleri ortaya konulmuştur. Atud Bölgesi’nde serpantinitler, bunların türevleri ve metatüfler, metagabro-diyorit kompleksi tarafından kesilmektedir. Metagabro-diyorit kompleksi ise olivin gabronoritik kayaçlar tarafından kesilmektedir. Serpantinitler, talk-karbonat ve kalk-silikat kayaçları metamorfik peridotitler olarak adlandırılmıştır. Nadir toprak elementleri (NTE) davranışları, HNTE ve pozitif Eu-anomalisi ile ANTE zenginleşmeleri ile karakterize edilir. Bu durum, hidrotermal akışkanların plajiyoklaz çözünmesi ve/veya sirkülasyonu ile doğada meydana gelen okyanus serpantinleşmesine işaret etmektedir. Metatüfler çoğunlukla en yüksek K/Rb oranına sahip olan bazik ile ortaç dereceli magma odalarından türetilmiştir. NTE paternleri, HNTE açısından zenginleşmiş, ANTE'den yoksun ve negatif Eu anomalilerine sahip genelde toleyitik ve kalk-alkalin kayaçlarla okyanus ada yayının metasedimentlerine benzemektedir. Ayrıca, dalma-batma zonu boyunca manto kaynağına eklenen bileşenler tarafından kirlenmiş bir magmadan kaynak kayaçlarının oluştuğunu ifade etmektedir, yani negatif Eu-, Sr- ve Zr- anomalileri göstermektedir. Metagabro-diyorit kompleksi kayaçlarının sırasıyla kalk-alkalin gabro ve gabro/diyorit ve diyorit ve gabro/diyorit olduğunu ortaya koymaktadır. Bu kayaçlar, sırasıyla metagabrolar ve diyoritler için klinopiroksen ve amfibol fraksiyonasyonuna işaret eden ada yayı ortamlarında meydana gelen kalk-alkali bazalt (CAB) ile karşılaştırılabilir. Öte yandan, olivin gabronorit kayaçları, K toleyitik magmatik afinitelere sahip gabroik kayaçlar olarak sınıflandırılır. NTE paternleri, HNTE ile zenginleşmeyi ve pozitif Eu-, Th-, Pb-, Sr- ve Zr-anomalileri ve plajiyoklaz ve olivin düşük basınçlı fraksiyonasyonunu ima eden negatif P- ve Ti-anomalileri ile ANTE açısından tüketilmeyi ortaya koymaktadır.
Dimension Reduction Based Robust Digital Image Watermarking Using Truncated Singular Value Decomposition and Discrete Wavelet Transform
Authors: YURTTAKAL Ahmet Haşim , HORASAN Fahrettin
Published: October 2022

Telif hakkı koruma, kimlik doğrulama, parmak izi, içerik etiketleme gibi alanlarda kullanılan damgalama tekniklerinde genel olarak sinyal işleme dönüşümleri ve matematiksel teknikler kullanılır. Bu araştırmada çoğu damgalama tekniğinde tercih edilen Tekil Değer Ayrışımı (TDA) yerine, boyut indirgeme tabanlı Kesik-TDA tekniği kullanılmıştır. Önerilen bu teknik Ayrık Dalgacık Dönüşümü (ADD) ile birlikte kullanılmıştır. Temel TDA-ADD tabanlı yönteme göre önerilen yöntemin histogram eşitleme dışında tüm olası saldırılara karşı algılanamazlık ve dayanıklılık performanslarında ilerleme kaydettiği gözlenmiştir. Önerilen şemanın farklı matris ayrışımı ve sinyal işleme dönüşümlerinin kullanıldığı alternatif damgalama şemalarına yön vereceği tahmin edilmektedir.
Equilibrio simultáneo de las curvas IS-LM (versión subtitulada)
Authors: Sánchez-Rivas García Javier , Pablo-Romero Gil-Delgado María del Pópulo , Molina Toucedo José Antonio , Expósito García Alfonso , Gómez-Calero Valdés María Palma
Published: October 2022

Explicación macroeconómica del modelo IS-LM en su equilibrio simultáneo adaptado las disfunciones auditivas del alumnado.

Animación didáctica que trata sobre el equilibrio simultáneo del mercado de bienes y dinero, explicando, paso a paso, los gráficos necesarios para construir el citado equilibrio.

Dentro de las tecnologías multimedia, el uso de vídeos (como material de enseñanza) ha atraído la atención de los docentes debido a sus beneficios para el aprendizaje, tanto en términos de atención como de motivación de los estudiantes (Almobarraz, 2018; Brecht, 2012;Orús et al., 2016; entre otros). Entre los beneficios del aprendizaje, la literatura existente resalta los siguientes: 1) permite un proceso de aprendizaje más flexible temporal y espacial; 2) representa un ahorro en costes y tiempo tanto para los estudiantes como para las instituciones educativas; 3) mejora la autonomía del
estudiante en el proceso de aprendizaje; y 4) promueve el aprendizaje colaborativo y bajo demanda.

Actualmente se está realizando un testeo con el alumnado con disfunciones auditivas de la Asignatura de Economía II del Grado de Turismo que culminará con una comparativa de las notas en el curso anterior a la puesta a disposición del mismo del material preparado. Se espera que las calificaciones sean superiores con el uso de este vídeo.
PENGEMBANGAN DESA WISATA DI KABUPATEN ENDE SEBAGAI UPAYA PENCEGAHAN URBANISASI
Authors: H. N. Mari Natalia Adel
Published: October 2022

The change from mass tourism to alternative tourism provides an advantage for tourist villages to be an option in tourism development. Rural areas with their unique characteristics, such as unspoiled natural environment, beautiful natural scenery, various kinds of animals and plants, rural people and culture, present a unique experience to tourists. This study uses a qualitative method with a descriptive-analytic model. Tourism villages are able to reduce the urbanization of people from villages to cities because many economic activities in villages can be created. In addition, tourist villages can be an effort to preserve and empower the potential of local culture and local wisdom values ​​that exist in the community. As an effort to suppress the existing rate of urbanization, the development of tourist villages is a form of solution that can be carried out by every village. In developing a village into a tourist village, many aspects are absorbed, especially the provision of jobs in the village which are increasingly varied and able to absorb the existing workforce in rural areas.
Implementing Online Informal Learning to Engage Interpreter Trainees Amid COVID-19 a Pilot Evaluation
Authors: Yan Da , Fan Qiongqiong
Published: October 2022

Sudden shifts towards online education since the outbreak of Covid-19 propelled the unprepared changes in teaching and learning over the world. The effects of transferring Interpreting training from face-to-face instruction and practices to a fully online environment was reviewed differently. Issues such as relatively inferior engagement in learning and dissatisfied performance in competence building were highlighted and compounded by the concern of academic burnout and learning stress caused by the abiding pandemic. To curb the unsatisfactory situation, alternative learning methods and innovative pedagogical approaches were advocated. The present study was a pioneering effort to integrate informal learning into remote interpreting training by developing and implementing an online informal learning communities for undergraduate interpreting trainees in a Chinese university. The researcher recruited 36 students (N=36) and 7 lecturers (N=7) from the institution as participants in the 1.5-year piloting project. The findings of the research revealed the effectiveness of informal learning in supplementing formal education by engaging involved students. Student-centered learning supported by collaborative and experiential activities in an informal environment was well-received for its ability to galvanize student’s engagement and academic achievements. The perceptions from participants revealed preference and expectation from students for expanded roles of trainers in interpreting training.
INTRODUCTION OF A PROJECT OFFICE AT A MACHINE-BUILDING ENTERPRISE
Authors: Mineeva T.A. , Kuznetsova N.A. , Kalinina N.E.
Published: October 2022

This article is devoted to the problems of implementing a project office at a machine-building enterprise. The combination of serial production and individual orders is of particular relevance in modern conditions. The purpose of this article is to adapt the concept of implementing a project office to the management structure. The project office is a versatile, highly efficient method that allows you to combine serial and custom production methods. The hypothesis of the project approach to the organization of work of enterprise divisions applying possibility is considered. The tools of the project approach are considered on the example of the product development process in the production of an enterprise in the article. Structural-logical and matrix models of the control system are built. The analysis of responsibility areas and break points is carried out. A new model of interaction between departments is proposed. The division of responsibility into production and administrative components is considered. The situation of the order division into subprojects according to the stages of the production process of the product while maintaining the logic of project management is also discussed. The separation of functions between the administrator and the head of the project for the implementation of an individual order is described. The stages of analysis are accompanied by graphic illustrations, tables that allow you to visually demonstrate the logic of applying the method to the work of the enterprise. As a result, an optimal concept of the process of introducing a new product into production is formed.
ANALYSIS OF STATE SUPPORT MEASURES FOR SMALL BUSINESS IN MODERN CONDITIONS
Authors: Sharafieva L.I. , Volkova T.G.
Published: October 2022

The modernization of Russia implies a qualitative breakthrough in the small business sector, using new technologies and developing the innovation sphere. The creation of a developed small business can solve many modern Russian problems, so the state should develop small businesses and, if necessary, support them. The issues of the need to support small and medium-sized enterprises became especially acute during the coronavirus pandemic and continue to be relevant both abroad and in Russia. The first part considers the share of small enterprises in the overall structure of enterprises in world practice, as well as general measures to support this category of enterprises. The second part is devoted to the analysis of support measures provided in connection with COVID-19 in developing and developed countries of the world. Different countries offer their own support measures, the analysis and implementation of which can help other countries to fight the crisis. The study of domestic and foreign experience in providing support to small and medium-sized businesses made it possible to identify general and private forms of assistance. The authors concluded that support measures for all countries are aimed at reducing the tax burden and concessional lending.
LOCALIZATION OF INDUSTRY IN THE ECONOMIC AREA OF THE RUSSIAN FEDERATION: ASSESSMENT APPROACHES AND MAIN CHARACTERISTICS
Authors: Shatalova O.M.
Published: October 2022

The article is devoted to the problem of the area organization of the industrial sector of the economy. The purpose of the research was to form numerical characteristics of the existing distribution of manufacturing activities in the manufacturing industry. The relevance of the topic and the results obtained is due to the high socio-economic and political significance of the industrial sector of the economy. The research was carried out using the author's algorithm, built on the use of a set of universal analytical methods. The methodological complex used includes: a method for calculating the localization coefficient, a method for measuring the level of concentration of manufacturing industries, as well as a method for assessing their regional structure. The proposed research algorithm involves the use of data generated in the system of state regional statistics. As a result of testing the algorithm, the composition of industrially oriented regions of the Russian Federation was determined, quantitative estimates of the spatial concentration of the manufacturing industries were given, and analytical interpretations were compiled. Based on the results of the research, it can be concluded that the author's approach has shown high analytical capabilities and makes it possible to draw up a detailed characteristic of the manufacturing sector. This characteristic is important in clarifying the content of the country's spatial development strategy and its practical implementation at the level of government regional administration.