bluuebunny/crossref_metadata_2025 huggingface dataset:
Non-clinical safety evaluation of a novel pharmaceutical salt, rosuvastatin ethanolamine, in Wistar rats
Authors: Vaghasiya Jigneshkumar , Patel Satyam , Patel Sudhir , Kadam Shekhar , Ranvir Ramchandra , Patel Harilal , Sundar Rajesh , Jain Mukul
Published: February 2020

Rosuvastatin, a second generation 3-Hydroxy-3-Methyl Glutaryl Coenzyme-A reductase inhibitor, is widely used for the management of hypercholesterolemia. Rosuvastatin ethanolamine, developed by Cadila Healthcare Ltd., is a novel, chemically stable, and pharmaceutically acceptable salt, having better physiochemical properties than commercially available Rosuvastatin salt. The objective of the present study is to evaluate safety, tolerability, and toxicokinetic profile of novel salt. Therefore, four weeks repeated dose oral (gavage) toxicity and toxicokinetic study of Rosuvastatin ethanolamine was carried out. The drugs were administered once daily at salt corrected dose of 15, 40, and 100 mg/kg for four weeks. No signs of toxicity were observed during repeated (four weeks) oral administrations of Rosuvastatin ethanolamine in rats up to 40 mg/kg. Single male mortality was observed at 100 mg/kg dose. Microscopy finding in liver was minimal to mild bile ductular proliferation, single cell necrosis, and hepatocellular vacuolation of cytoplasm with associated statistically significant serum elevation of transaminase enzymes; AST, ALT, ALP, and/or liver functional marker; total bilirubin with at ≥40 mg/kg. The systemic exposures (AUC0–24 and Cmax) were not markedly different between males and females, or between the administration periods (except high dose, where exposure on day 28 was approximately 2 to 3 fold higher than that of day 1. In conclusion, Rosuvastatin ethanolamine exhibited toxicities to liver as the target organ at ≥40 mg/kg in this study. These adverse effects with associated exposures should be taken into consideration for the future assessing of potential Rosuvastatin toxicities.
Positive and inverse correlation of blood lead level with erythrocyte acetylcholinesterase and intelligence quotient in children: implications for neurotoxicity
Authors: Nwobi Nnenna Linda , Adedapo Solomon Kayode , Olukolade Olugbemi , Oyinlade Opebiyi Alexander , Lagunju Ikeoluwa Abiola , Atulomah Nnodimele Onuigbo , Nwazuoke Ikechukwu Ambrose , Anetor John Ibhagbemien
Published: February 2020

Blood lead level (BLL) is insufficiently sensitive for early detection of Lead-induced neurotoxicity (LIN). This study determined the possible role of the combination of BLL, intelligent quotient (IQ) and erythrocyte acetylcholinesterase (AChE) activity in the early detection of LIN in Children. Apparently healthy children (n=309) from eight public primary schools in Ibadan, Nigeria were recruited and classified into: children with Elevated BLL (EBLL) and children with Acceptable BLL (control) based on CDC cut-off for childhood lead exposure. Neurological indices (speech, memory, cranial nerves and cerebellar functions), IQ, BLL and erythrocyte AChE activity were assessed using standard methods, Standard Progressive Matrices, AAS and HPLC respectively. Statistical analysis involved Student’s t-test, Pearson’s correlation and multivariate regression. p<0.05 was considered significant. There were 169 (54.7%) children with EBLL while there were 140 (45.3%) control children. Both groups exhibited normal speech, memory, cranial nerves and cerebellar functions. However, IQ was lower in EBLL children (85.9±11.6) compared with control (91.5±14.0) while BLL and AChE activity were higher in EBLL children (0.4±0.1 µmol/l; 117.5±25.5 µkat/l) compared with control (0.2±0.0 µmol/l; 59.4±10.2 µkat/l). BLL showed inverse correlation with IQ (r=–0.134, p=0.019) but positive correlation with AChE (r=0.978, p≤0.001). 16.2% of the observed variation in BLL could be accounted for by AChE using the equation; [BLL=–0.007+0.003 AChE] p<0.05. Elevated blood lead level is prevalent among the school children and appears to have adverse effect on their IQ. Erythrocyte AChE could be a promising marker for early recognition of significant environmental lead exposure and lead-induced neurotoxicity in children.
Multicriteria Evaluation of Intermodal (Rail/Road) Freight Transport Corridors
Authors: Janić Milan
Published: February 2020

This paper deals with the multi-criteria evaluation of the intermodal (rail/road) freight corridors as competing transport alternatives. For such a purpose, the methodology has been developed consisting of two main components; i) the analytical models for estimating the indicators and measures of the corridors’ physical/spatial or infrastructural, technical/technological, operational, economic, social, and environmental performance; and ii) the MCDM (Multi-Criteria Decision Making) method using the above-mentioned indicators and measures of performance as the evaluation attributes/criteria in ranking and identifying the preferred among the several mutually competing freight transport alternative corridors.

The proposed methodology has been applied to two Trans-European intermodal rail/road freight transport corridors. As such, it has shown to be of use, in addition to the researchers, also to the other potential DMs (Decision Maker(s)). These could be, for example, the freight shippers/receivers as the users of the already existing intermodal (rail/road) transport services, the transport and intermodal terminal operators and infrastructure providers, and the business and policy makers facing with the problems of allocating the usually limited investments in the social-economic feasible way to the corresponding infrastructure at the local, regional, national, and international scale.
Problems Affecting the Accessibility of Physically-Challenged Individuals to Intermediate Public Transport Services in Oyo State, Nigeria
Authors: Ajayi Julius , Aworemi Remi , Wojuade Christopher , Adebayo Toyin
Published: February 2020

The greatest challenge of physically-challenged individuals is mobility, thereby making access to public transportation essential to independent living for these individuals. The study was conducted in Oyo State. Multistage sampling method comprising purposive and simple random sampling was used to select a sample size of 226 students from three special education centres in the state. Findings revealed that factors such as operators’ impatience/discrimination, waiting time and lack of assistance were major problems that affects accessibility to IPTs. Furthermore, results showed that difficulties experienced by the physically-challenged individuals differ significantly by the nature of disability as evidenced by a chi-square value of 37.218, p<0.05. It was therefore recommended that government should listen more to these transport disadvantaged people living with disabilities and integrate their concerns/suggestions in the design, implementation and monitoring of transport infrastructure and services as well as providing sustainable transport means to their transport challenges.
Health Literacy – a review of research using the European Health Literacy Questionnaire (HLS-EU-Q16) in 2010-2018
Authors: Niedorys Barbara , Chrzan-Rodak Agnieszka , Ślusarska Barbara
Published: February 2020

Introduction. The concept of health literacy is often used as “health competence”, “health ability. It involves the skills and motivation of people to obtain and understand health information. To improve health understanding and assessment of health literacy, many instruments have been developed to measure health competences in different populations. Among them there is the multidimensional, comprehensive questionnaire HLS-EU-Q16, developed by the Consortium of European Countries.

Aim. Review of health literacy studies using the European Health Competence Questionnaire (HLS-EU-Q16) based on literature analysis.

Method. Thematic review, unsystematic literature covering the years 2010-2018. The number of 17 source items was analyzed by the authors.

Results. The overall level of health literacy was higher in European research than in non-European research. Low levels of health literacy were found in the elderly and chronically ill, immigrants and prisoners, as well as people with low education. The analysis of the research shows that the limited health skills of the respondents are related to the deterioration of the functional state and cognitive skills in the elderly. The decisive determinant of the low level of health literacy among immigrants and prisoners is unemployment and low level of education. Adequate health education plays a key role in improving the social level of health awareness and contributes to the long-term health of the entire population.
Assessment of a College Orientation Course for International Students
Authors: Fletcher-Anthony Wilma , Efthymiou Lampeto
Published: February 2020

Orientation programs beyond a single experience are useful for the creation of peer relationships, development of college student identity, and fostering a connection to the college (Soria, Lingren Clark, & Coffin Koch, 2013). In the case of international students, Olivas and Li (2006) recommend that these programs address cultural factors and the demands of the U.S. education system and promote campus services. The purpose of the article is to describe a college orientation course for international students and to examine feedback from course participants in order to identify potential changes to content and delivery for improved outcomes.
The Relationship Between Students' Family Communication, Transition Efficacy, and Communication Skill
Authors: Scharp Kristina M. , Hall Elizabeth Dorrance , Sanders Matthew , Colver Mitchell
Published: February 2020

Family communication patterns theory (FCP) was first introduced by McLeod and Chaffee (1972), was later adapted in 1990 by Ritchie and Fitzpatrick, and was formally articulated by Koerner and Fitzpatrick in 2002. The theory is primarily used by communication studies scholars interested in how a family’s communication environment predicts a variety of outcomes. FCP suggests that families communicate in fairly predictable ways that get reinforced through the process of social learning (see Kunkel, Hummert, & Dennis, 2008).
Diez prácticas violentas ejercidas cotidianamente por estudiantes de secundaria
Authors: Dorantes Carrión Jeysira Jacqueline , Domínguez Quevedo Blanca Laura
Published: February 2020

Se presentan los resultados de una investigación efectuada en una escuela secundaria de Xalapa, Veracruz, que participó en la implementación de la Ley número 303 contra el acoso escolar para el estado de Veracruz (2011) y del Programa Nacional de Convivencia Escolar (2017). Damos a conocer la violencia, sus modalidades más relevantes y la frecuencia con la que la sufren los estudiantes en el interior de un centro escolar. El instrumento de investigación (cuestionario) fue proporcionado por la Fundación Paz Ciudadana de la República de Chile y adaptado al contexto veracruzano. Los resultados muestran la presencia de diez prácticas violentas cotidianas que ejercen los estudiantes entre pares y por jerarquías predominantes, los cuales se analizan a partir de la experiencia escolar (Dubet y Martuccelli, 1998).Palabras clave: Prácticas violentas, Estudiantes, Secundaria, Educación básica Ten daily violent practices among high school studentsSummaryThe results of an investigation carried out at a secondary school in Xalapa, Veracruz, which participated in the implementation of Law 303 against bullying for the state of Veracruz (2011) and of the National Program of School Coexistence (2017) are presented. A description of the violence, its most relevant modalities and the frequency with which it is suffered by students inside a school is described. The research instrument (questionnaire) was provided by the Fundación Paz Ciudadana of the Republic of Chile and adapted to the context of Veracruz. The results show the presence of ten daily violent practices that students apply among peers and by predominant hierarchies, which are analyzed based on school experience (Dubet and Martuccelli, 1998).Keywords: Violent practices, Students, Secondary, Basic education Dix pratiques violentes et quotidiennes parmi des étudiants d’école secondaireRésuméOn présente les résultats d’une recherche effectuée dans une école secondaire de Xalapa, Veracruz, qui a participé dans l’implémentation de la Loi numéro 303 contre le harcèlement scolaire pour l’État de Veracruz (2011) et du Programa Nacional de Convivencia Escolar (2017). Nous révélons la violence, ses modalités les plus importantes et la fréquence avec laquelle les étudiants la subissent à l’intérieur d’un centre scolaire. L’instrument de la recherche (questionnaire) a été fourni par la Fondation Paz Ciudadana de la República de Chile et adapté au contexte de Veracruz. Les résultats montrent la présence de dix pratiques violentes quotidiennes qui exercent les étudiants entre pairs et par hiérarchies prédominantes, lesquelles sont analysées à partir de l’expérience scolaire (Dubet et Martuccelli, 1998).Mots clés: Pratiques violentes, Étudiants, École Secondaire, Éducation élémentaire
The Effects of Education on Job Satisfaction Among Young Workers in Vietnam
Authors: Quy Thanh Nguyen , Anh Nguyen Thuy , Anh Tran Lan , Bich Nguyen Thi
Published: February 2020

Using secondary data from the School-to-Work Transition Survey-SWTS in 2012-2015, this study examines the effects of education on job satisfaction among young workers in Vietnam. Both descriptive statistics and logistic regression analysis were used in the study. Our econometric analysis shows that individuals with higher levels of education are less likely to have lower levels of jobs satisfaction. The result is robust even after controlling for many important controlling variables such as occupations, wages and economic household status. This finding can be explained that those with better education tend to have higher expectation for their work, which in turn can have lower levels of job satisfaction. Our research finding implies that while better education can improve wage earnings, it might not improve job satisfaction.
Body Condition in Birds in Two Landscapes of the Upper Magdalena Valley, Colombia
Authors: Sánchez-Guzmán Jessica Natalia , Losada-Prado Sergio
Published: February 2020

The body condition (BC) is the sum of factors such as the state of energy reserves, the degree of health and the physiological wear of an individual. Despite its importance and the existence of a wide range of methodologies to measure it, in the Neotropic there are few works that value this variable in contrast to environmental conditions. The aim of this study was to analyze the BC during the years 2012-2013 of 13 bird species in two intervened landscapes in the tropical dry forest, located in the north of Tolima and the southwest of Huila in the region of the upper Magdalena Valley (UVM). The BC of species was assessed using the scaled mass index (SMI), using morphometric data such as wing chord, tarsal length and body mass. Significant differences were found in the SMI between landscapes and climatic seasons in the species Formicivora grisea, Saltator striatipectus, Sporophila schistacea and Basileuterus rufifrons. It was concluded that environmental variables evaluated affect the BC of some species but not the avifauna in general, mainly due to the effect of these variables on the availability of resources, the necessary energy spending to obtain them and the sensitivity of species to environmental changes.
ANALISA BENTUK FURNITURE SEBAGAI MEDIA DUDUK PADA AREA FOODTRUCK
Authors: Putri Desy Dwi
Published: February 2020

Basically the application of Foodtruck in modern society is classified as a sales medium that is required to move freely with consideration of location that can change, in the application of foodtruck design must include efficiency in mobilization and interior that is in accordance with the character of foodtruck , namely the use of interior elements as optional gasket that must be considered in the foodtruck design method, including furniture thatdominates the layout of the room. Furniture design in the foodtruck area becomes the foundation in the form of rules that answer the problem of an activity. The process to produce an object that has a high value of economic, aesthetic and functional. In the method of applying geometry to a stoolcan be used as a reference in construction, supporting activities, capacity and integrity of the results of a design process, in the stoolthere are some basic problem identification and relevance to the geometry transformation process and examine any errors that must be avoided in a stooldesign with the aim of meeting standards, to minimize errors in a design concept stoolthat plays in the scope of geometry and shape transformation
A Review on Information System Audit Using COBIT Framework
Authors: Nugroho Heru
Published: February 2020

Information systems (IS) audit contains a proper review of risks associated along with the organization of information systems and processes. Also, an assessment of whether enough quality control will ensure the efficiency, effectiveness, integrity, and security of organization data and assets of the information system. An IS / IT audit is a coordinated process that specializes in high-risk areas in the organization. Selection of the areas can arise with the board of directors, the board of directors, audit committee, government agencies, or external audit organizations. Generally, it audits help organizations monitoring and evaluation of how the business is work and give protection to the interests of managers, workers, customers, and investors. Control Objectives for Information and related Technology (COBIT) is a detailed resource that consists of all the information organizations have to be compelled to adopt its governance and control framework. COBIT delivers good practices across all domains and process frameworks in an easily manageable and rational structure to assist in optimizing investments that support it. COBIT optimizes investments that support IT and ensure that IT successfully meets business requirements. In this paper, we find that paper about IT/IS audit using COBIT is had a different perspective. Base on the review from twenty papers, there is 85% with a title IT/IS Audit, but the content is about Maturity or Capability Level. The discussion paper is expected to provide new knowledge to other researchers who focused his research on the area of information systems audit. This paper is expected to provide new enlightenment that information system audit is different from the maturity/ capability level, which is also examined in the COBIT 4.1 framework.
Inventory Planning with Method Q and Method P for Probabilistic Demand on Chrysanthemum Seeds at PT Transplants Indonesia
Authors: Sutoni Akhmad , Taufik Dani Hamdan
Published: February 2020

Fluctuating and uncertain demand is a problem faced by manufacturing firms. The problem can be mitigated by the availability of inventory systems. This inventory serves to ensure the availability of appropriate resources in the right quantity and at the right time, so as to minimize the costs incurred. PT. Transplants Indonesia is a company engaged in the business of chrysanthemum flower in Indonesia. PT. Transplants Indonesia is a subsidiary of Okinawa Flower Agricultural Cooperative Association (OKF) in Okinawa, Japan. The purpose of this company establishment is to meet the demand of farmers who are members of the OKF.  In the case of backorder, on Q method with probabilistic request the size of the lottery (Q) is always fixed for every time the order is made and the order is made if the amount of inventory system has reached a certain level (r) called the reorder point. In method P with probabilistic order requests made according to a fixed interval of time (T) and the ordering does not exceed the maximum inventory limit (R). Total Inventory cost incurred by the company using the method used by the company amounted to Rp.74.995.360,84. The inventory model using the Q method generates a total inventory cost of Rp.70.253.291,46. Meanwhile, inventory model using P method resulted in total inventory cost of Rp.71.529.327,17. So economically, the selected inventory model is the inventory model with the Q method which has a lower total inventory cost value than using the P method.

 

Keywords— Inventory system, Probabilistic, Backorder, Method Q, Method P, Reorder point.
DETERMINATION OF INVENTORY PERIODIC REVIEW POLICY (R, s, S) USING POWER APPROXIMATION METHOD FOR MINIMIZE TOTAL INVENTORY COST IN PT. OPQ
Authors: - Ratnawia , Aurachman Rio , Kenaka Saskia Puspa
Published: February 2020

OPQ is a company engaged in the automotive manufacturing industry. The company produces bolts for the safety area, it is related to the lower body of the four-wheeled vehicle. PT. OPQ was established in 2014 and today has already been the supplier for several major automotive companies in Indonesia. The demand of PT OPQ that must be fulfilled is increasing as the amount of consumer is increasing too. Due to the high demand, so the raw material stockout occurs. This make the company's service level is below the standard.

 

This study involved 48 sku of material raw materials that have normal distributed demand. Inventory policy applied in this research is periodic review (R, s, S) with the aim to minimize total cost of inventory and improve service level of company.

 

The result of this research was found to decrease total inventory cost by 15% with the value of existing inventory cost Rp1.100.879.479,- to Rp 936.061.349,- . In addition, service level at PT. OPQ has increased with the value of existing conditions 85% to 99%.

 

Keywords—Raw Material, Periodic Review, Probabilistic, Service Level, Stock out
ANALISIS PEMASARAN BERBASIS HUBUNGAN PT. XYZ DENGAN HOREKA DI BOGOR
Authors: Rantetoding Rangga Jayanti , Yuliati Lilik Noor , Suharjo Budi
Published: February 2020

The  influence  of  the  growth  of tourism  industry  which  affected the  increasing  demand  for  beef  also  occurs  in Bogor City and Regency. This research was conducted at PT XYZ with their business partners Horeka in Bogor. The  relationship  between  PT  XYZ  and  100  business  partners  in  Bogor  is  a  marketing  relationship  between suppliers  and  suppliers,  in  which  PT  XYZ  acts  as  a  supplier  and  company  as  a  product  distributor  to  end consumers. The purpose of this study was to analyze relationship-based marketing between PT XYZ and Horeka business  partners  in  the  city  of  Bogor.  Data  was  obtained  by  the  census  method  on  100 Horeka  business partners who had made purchases at least twice in the past month at PT XYZ until August 2018. The research methodin this study  was descriptive  analysis using the  Top two boxes method and Structural Equation Model (SEM) with Lisrel tools. Based on the results of descriptive analysis, it can be seen that 98 percent of people try to  promote  mutually  beneficial  cooperation.  The  results  of  the  SEM  model  analysis  show  that  the  pattern  of linkages that occur in relationship-based marketing of PT XYZ with business partners is not only based on mere financial  benefits.  The  relationship  that  was  built  between  PT  XYZ  and  Horeka  business  partners  was  based more on trust based on flexible business practices.
Keywords—Commitment, Cooperation, Relationship Marketing, Trust
Abstrak
Pengaruh  pertumbuhan  industri  pariwisata  yang  juga  menjadi  pengaruh  meningkatnya  kebutuhan  daging  sapi terjadi juga di Kota dan Kabupaten Bogor. Penelitian ini dilakukan pada PT XYZ dengan mitra usaha horeka di Bogor.  Hubungan  antara  PT  XYZ  dengan  100  mitra  usaha  horeka  di  Bogor  merupakan  hubungan  pemasaran antara  pemasok  dan  penyalur.Tujuan  penelitian  ini  adalah untuk  menganalisis  pemasaran  berbasis  hubungan antara PT XYZ dengan mitra usaha horeka di kota Bogor.Data di peroleh dengan metode sensus pada 100 mitra usaha  horeka  yang  sudah  melakukan  pembelian  minimal  dua  kali  dalam  satu  bulan  terakhir  pada  PT  XYZ sampai  dengan  bulan  Agustus  2018.  Metode  penelitian  yang  digunakan  dalam  penelitian  ini  adalah  analisis deskriptif  dengan  menggunakan  metode Top  two  boxesserta Structural  Equation  Model(SEM)  dengan  tools Lisrel. Berdasarkan hasil analisis deskriptif, dapat diketahui bahwa 98 persen horeka berupaya mengedepankan kerjasama  saling  menguntungkan.  Hasil  analisis  model  SEM  menunjukan  bahwa  pola  keterkaitan  yang  terjadi dalam  pemasaran  berbasis  hubungan  PT  XYZ  dengan  mitra  usaha  horeka  tidak  hanya  didasarkan  pada keuntungan  finansial  semata.  Karena  hubungan  yang  terbangun  antara  PT XYZ  dan  mitra  usaha  horeka  lebih didasari karena kepercayaan yang berpedoman pada praktek bisnis yang fleksibel.
Kata kunci— Kepercayaan, Kerjasama, Komitmen, Pemasaran Berbasis Hubungan
Curricular Engagement with Reference to Vygotski’s Thoughts
Authors: S. Mali Nagina , A. Kamble Smt. Saraswati
Published: February 2020

Education helps to learner’s personal, social and academic development. Society is the community that provides positive environment to school where learner learns. It is universal expectation from learner that they should become active and make interaction with society. Nowadays, students are becoming active, creative and collaborative. But how learner learns is a valuable dimension of learner’s social development. Where learner is unable to learn individually, in that case there is need of peers, adults and assisted media that can promote and help in learning joyfully. Vygotski's thoughts are related to learner’s social development. His ZPD (Zone of Proximal Development) is a valuable contribution in education. He considers learner’s language, culture, intellectual level, peers, media and adult affects on learner’s development. Curricular Engagement is one of the Teaching-Learning approach that involves in learner’s social development. It is interactions between school, learner, society, teacher and media. Interaction builds knowledge, creates healthy relationship, leads to win-win approach and provides cultural environment. The similarities of Vygotski’s theory and Curricular Engagement both are emphasizes on interaction with peer, teacher, media and adult. In this conceptual paper researchers have explained how Vygotskian thoughts support to curricular engagement with multicultural, multilingual context.
Transtorno da compulsão alimentar no ambiente de trabalho: uma revisão bibliográfica
Authors: Silva Brunna Dantas da , Atherino Juliana Campos , Lima Rayanne Silva Vieira
Published: February 2020

Objetivo: Realizar uma revisão narrativa sobre a presença do transtorno da compulsão alimentar no ambiente laboral. Revisão Bibliográfica: O transtorno da compulsão alimentar é caracterizado, principalmente, pela presença de episódios recorrentes de compulsão alimentar, sem a companhia de um mecanismo compensatório para combater um possível aumento do peso corporal. Sabe-se que os distúrbios do comportamento alimentar possuem uma etiologia multifatorial e há evidências de que o ambiente de trabalho pode ser um fator desencadeante de doenças, dependendo das condições que as atividades laborais são executadas. Nesse sentido, observou-se que as circunstâncias na quais o trabalho é realizado pareciam apresentar relação com a prevalência do transtorno da compulsão alimentar, sendo observada uma maior prevalência dessa enfermidade em trabalhadores com estresses psicossociais, obesidade e insatisfação ou disfunção da imagem corporal. Considerações Finais: É importante a preocupação com a saúde do trabalhador, principalmente aqueles que desempenham atividades de alta exigência, evitando ambientes e condições laborais que podem desencadear transtornos nutricionais.
Modelo simulador prático e de baixo custo para treinamento de timpanotomia com colocação de tubo de ventilação
Authors: Brandão André dos Santos , Rodrigues Jussandra Cardoso , De Souza Felipe Xavier , Andrade Jocyane de Souza , Barbosa Ana Larisse Gondim
Published: February 2020

Objetivo: Demonstrar um modelo de simulador cirúrgico, prático e de baixo custo, para a prática de timpanotomia com colocação de tubo de ventilação. Método: Desenvolvimento experimental de um modelo para treinamento cirúrgico, construído a partir de uma infra-estrutura com duas plataformas de madeira, uma como base e outra como suporte para o molde, interligadas por uma haste articulada de metal. O molde foi formado a partir de seringas serradas em um comprimento de 2,5 cm, com um anel membranoso de Policloreto de Vinil fixado com um amarrilho de plástico em sua ponta, simulando respectivamente conduto auditivo externo e membrana timpânica. Resultado: O simulador após montado permite a prática do procedimento desejado, além de outros como aspiração, retirada de cerume e corpos estranhos do conduto adutivo externo, podendo ser executados com auxilio tanto do microscópio, como do endoscópio rígido. Conclusão: O modelo é uma alternativa barata e prática para treinamento de timpanotomia com colocação de tubo de ventilação e outros procedimentos da rotina otorrinolaringológica, e o treinamento com o uso do simulador permite ao usuário dominar as habilidades necessárias e se familiarizar com os equipamentos e instrumentais para a execução destes procedimentos no ambiente cirúrgico real.
Using Experiential Learning Theory to Improve Teaching and Learning in Higher Education
Authors: Jonathan Leong Y. , Laik Ma Nang
Published: February 2020

The importance of skills has been expounded repeatedly as a crucial factor to thrive in the workplace, as opposed to mere knowledge of content. It is important to be able to adapt to new situations; this is especially true in today’s world, where volatility, uncertainty, complexity, and ambiguity (VUCA) are prevalent. To better prepare undergraduates for entry to the workforce in such a tumultuous time, Experiential Learning Theory (ELT) can be employed in their programmes – for example, by using a computer simulation game called MonsoonSIM in a course on fundamentals of business modeling, or through an overseas experiential learning trip with thematic objectives. These two cases are chosen specifically as they deal with contrasting experiences of learning – one highly theory-based and typical of academic institutions, and the other geared toward practical skills.This paper explores the processes of the ELT, distinguishing it from common classroom experiences, and how they are applied in the two cases mentioned above in order to improve the quality of teaching and learning, and to inculcate self-directed learners who are able to better deal with environments of VUCA. The abovementioned cases serve as examples by which ELT can be deployed to improve both the breadth and depth of students’ learning. The content of this paper stems from the authors’ experiences in crafting, facilitating, and executing the ELT processes within the context of a university programme.
Fake News in the Corporate World: A Rising Threat
Authors: Adriani Roberto
Published: February 2020

Public opinion is used to thinking about fake news as a political phenomenon, a tool used to create dirty propaganda. It is true but it may be only the beginning. The literature is starting to realize that fake news may move from the political arena to the corporate world. If this should happen, fake news would overflow everywhere, making the post-factual society even more real. Fake news may become a dirty tool, used by dishonest companies to strike at their competitors’ reputation. The idea is that, till now, fake news has been used primarily for dirty propaganda and, marginally, to make money through the clickbait. However, since clickbait is a very basic approach, what we can expect is a breakthrough of fake news. From clickbait to much more sophisticated technologies and strategies to beat competitors dishonestly or to influence the global financial markets, for instance. A very dark big idea, in this case. It means that, in a post-factual society, even competition in the corporate world can be affected by fake news, fuelled by the abuse of new powerful technologies (Murgia M. and Kuchler H. 2017). The consequence is usually a decrease in sales and revenues, with a snowball effect. (Gupta S. 2016). Corporate reputation is an intangible as well as valuable asset. What makes it so valuable is that a good reputation can help the company to operate; on the other hand, a sullied reputation makes the company weaker and slower.
Large-Scale Free Energy Calculations on a Computational MOF Database: Toward Synthetic Likelihood Predictions
Authors: Anderson Ryther , Gómez-Gualdrón Diego
Published: February 2020

Metal-organic frameworks (MOFs) have captivated the research community due to a modular crystal structure that is tailorable for many applications. However, with millions of possible MOFs to be considered, it is challenging to identify the ideal MOF for the application of choice. Although computational screening of MOF databases has provided a fast way to evaluate MOF properties, validation experiments on predicted “exceptional” MOFs are not common due to uncertainties on the synthetic likelihood of computationally constructed MOFs, hence hindering material discovery. Aiming to leverage the perspective provided by large datasets, here we created and screened a topologically diverse database of 8,500 MOFs to interrogate whether thermodynamic stability metrics such as free energy could be used to generally predict the synthetic likelihood of computationally constructed MOFs. To this end, we first evaluated the suitability of two methods and three force fields to calculate free energies in MOFs at large scale, settling on the Frenkel-Ladd path thermodynamic integration method and the UFF4MOF force field. Upon defining a relative free energy, ΔLMFFL, that corrects for some force field artifacts specific to MOF nodes, we found that previously synthesized MOFs tended to cluster in a region below ΔLMFFL = 4.4 kJ/mol per atom, suggesting a general first filter to discriminate between synthetically likely and unlikely MOFs. However, a second filter is needed when several MOF isomorphs are below the ΔLMFFL threshold. In 84% of the cases, the synthetically accessible MOF within an isomorphic series presented the lowest predicted free energy. The present; work suggests that crystal free energies could be key to understanding synthetic likelihood for MOFs in computational databases (and MOFs in general), and that the thermodynamics stability of the fully assembled MOF often determines synthetic accessibility.
Compaction of RNA Hairpins and Their Kissing Complexes in Native Electrospray Mass Spectrometry
Authors: Abi-Ghanem Joséphine , Rabin Clémence , Porrini Massimiliano , Rosu Frédéric , Gabelica Valerie
Published: February 2020

When electrosprayed from native solution conditions, RNA hairpins and kissing complexes acquire charge states at which they get significantly more compact in the gas phase than their initial structure in solution. Here we show the limits of using force field molecular dynamics to interpret the gas-phase structures of nucleic acid complexes in the gas phase, and we suggest that higher-level calculation levels should be used in the future.
An Efficient Imine Photocyclization as an Alternative to the Pictet-Spengler Reaction for the Synthesis of AzaBenzannulated Perylenediimide Dyes
Authors: Goujon Antoine , Rocard Lou , Cauchy Thomas , Hudhomme Piétrick
Published: February 2020

AzaBenzannulated PDI (AzaBPDI) dyes were synthesized in high yields via a new reaction sequence involving an imine condensation followed by visible light-induced photocyclization. The large scope and efficiency of this alternative to the Pictet-Spengler reaction is demonstrated, and allows the easy preparation of dimeric AzaBPDI as potential non-fullerene acceptors for organic solar cells.
Splicing of enhancer-associated lincRNAs contributes to enhancer activity
Authors: Tan Jennifer Y , Biasini Adriano , Young Robert S , Marques Ana C
Published: February 2020

Transcription is common at active mammalian enhancers sometimes giving rise to stable enhancer-associated long intergenic noncoding RNAs (elincRNAs). Expression of elincRNA is associated with changes in neighboring gene product abundance and local chromosomal topology, suggesting that transcription at these loci contributes to gene expression regulation in cis. Despite the lack of evidence supporting sequence-dependent functions for most elincRNAs, splicing of these transcripts is unexpectedly common. Whether elincRNA splicing is a mere consequence of cognate enhancer activity or if it directly impacts enhancer function remains unresolved. Here, we investigate the association between elincRNA splicing and enhancer activity in mouse embryonic stem cells. We show that multi-exonic elincRNAs are enriched at conserved enhancers, and the efficient processing of elincRNAs is strongly associated with their cognate enhancer activity. This association is supported by their enrichment in enhancer-specific chromatin signatures; elevated binding of co-transcriptional regulators; increased local intra-chromosomal DNA contacts; and strengthened cis-regulation on target gene expression. Our results support the role of efficient RNA processing of enhancer-associated transcripts to cognate enhancer activity.
Analisis Antropometrik Dan Kondisi Fisik Terhadap Keterampilan Menggiring Bola Dalam Permainan Sepakbola Pada Siswa SMA
Authors: Hendra Hendra
Published: February 2020

Penelitian ini bertujuan untuk mengetahuiKontribusi Antropometrik, Kondisi fisik dan Hubungan kontribusi Antropometrik dan Kondisi fisikterhadap keterampilan menggiring bola dalam permainan sepakbola pada siswa SMA Negeri 1 Lappariaja Kab. Bone. Penelitian ini termasuk jenis penelitian deskriptif. Sampel penelitian adalah 50 siswa yang dipilih secara acak dengan menggunakan teknik “random sampiling”. Teknik analisis data yang digunakan adalah teknik analisis regresi dengan menggunakan sistem SPSS Versi 20.00 pada taraf signifikan 95% atau a0,05.Hasil analisis data menunjukkan bahwa Antropometrik dan Kondisi fisik memiliki kontribusi yang signifikan dengan keterampilan menggiring bola dalam permainan sepakbola pada siswa SMA Negeri 1 Lappariaja Kab. Bone.  Antropometrik memiliki kontribusi sebesar 38,8%, Kondisi fisik memiliki kontribusi 39,2%, sedangkan Antropometrik dan Kondisi fisik memiliki kontribusi 47,1%.
STRATEGI PENCEGAHAN KECURANGAN (FRAUD) DALAM PENGELOLAAN KEUANGAN PEMERINTAH MENGGUNAKAN ANALYTICAL HIERARCHY PROCESS
Authors: Kurniasari Novia Tri , Fariyanti Anna , Ristiyanto Nirwan
Published: February 2020

Fraud phenomenon involves many actors from the government sector. Fraudulent practices in government has a negative impact on the economic and social sectors. Therefore, need for prevention effort to avoid state’s material and non material losses. The objectives of this study were to formulate fraud prevention strategies by using Analytical Hierarchy Process. Sources of data used in this study were questionnaires and interviews to 5 expert respondent. Strategies for fraud prevention on government financial management: (1) improving the supervision and control system, (2) improving the organizational culture, (3) formulating anti fraud value in the organization, (4) implementing reward system and punisment firmly, (5) anti fraud socialization for employees, and (6) forming agent of change. Key words: fraud prevention, internal control system, organizational culture, anti fraud value, Analytical Hierarchy Process
STRATEGI MENSINERGIKAN PROGRAM PENGEMBANGAN MASYARAKAT DENGAN PROGRAM PEMBANGUNAN DAERAH
Authors: - Akmaruzzaman , - Sumardjo , Hariyoga Himawan
Published: February 2020

Natuna regency is a rich area of natural resource products, but still includes underdeveloped areas in Riau Islands Province. Local governments have to make fundamental changes in building the infrastructure aspects, economic, and human resources to eliminate underdevelopment and reduce dependency on central government. The aims of this research are: (1). to evaluate the effectiveness and stakeholders’ perception of the CD program, in terms of participation and partnership; and (2) to formulate a strategy for synergizing the CD Program of Star Energy with the local government’s development program. The analytical methods that are used in this research are descriptive analysis and SWOT analysis. This research was undertaken in Palmatak Sub District and Siantan Sub District of Natuna District of Kepulauan Riau Province, from June until October, 2008. The results indicated that the government stakeholders perceived that the participation of the CD program’s beneficiaries was adequate, and that the partnership between Star Energy and the local government was inadequate. The result of SWOT analysis suggested that Star Energy needs to focus its CD program on sustainable activities, such as economic development and education programs. The strategy for increasing synergy with the local development programs is to intensify communication between the company and the local government through the formation of community development partnership forum.Keywords: Community Development (CD), Effectiveness, Policy Strategy
STRATEGI PENGEMBANGAN WISATA DI SITU PENGASINAN KOTA DEPOK
Authors: Pusporini Diah , Hakim Dedi Budiman , Hendrakusumaatmadja Sutara
Published: February 2020

Tourism destinations in Depok have not yet been integrated. Thus, tourism site with a concept of one stop recreation area need to be created and developed. By creating two scenarios, those are free and charged area, Situ Pengasinan is selected for its beauty and location. The purpose of the assessment is to find the perception of the community on tourism development, investement cost, the Willingness to Pay, investement suitability as well as the strategies need to be applied in the development. The result shows that most participants agree on the development plan. Financial analysis result says that the building of infrastructure and tourist attractions cost Rp 6,045 billion. Most of 51 percent of participants is willing to spend if it is charged with the amount of WTP value is Rp 7.309,52 per person. The development is also financially proper. The assessment results in several development strategies those are socialization, empowering the community, investor, infrastructure, and also institutional policy or support.Keywords: Financial Analysis, Tourism Development, Willingness to PayABSTRAK Belum terintegrasinya destinasi wisata di Kota Depok mendorong perlu dilakukannya pengembangan wisata dengan konsep one stop recreation. Dengan dua pilihan skenario, yaitu tanpa dan dengan pemberlakuan tarif, Situ Pengasinan dipilih sebagai lokasi pengembangan karena keindahan serta lokasinya. Kajian ini bertujuan untuk mengetahui persepsi masyarakat terhadap pengembangan wisata di Situ Pengasinan, besarnya nilai investasi yang dibutuhkan, kesediaan masyarakat (Willingness to Pay), kelayakan investasi kegiatan pengembangan, dan strategi pengembangan wisata di Situ Pengasinan. Metode yang digunakan dalam penelitian ini adalah regresi logistik, regresi linier, analisis finansial, dan Analytical Hierrachy Proccess (AHP). Hasil kajian menunjukkan persepsi responden yang menyambut baik rencana pengembangan. Hasil analisis finansial memperlihatkan bahwa diperlukan investasi sebesar Rp 6,045 milyar untuk pembangunan sarana prasarana dan atraksi wisata. Sebanyak 51 persen responden bersedia membayar Rp 7.309,52 per orang jika diterapkan skenario pemberlakuan tarif. Hasil analisis kelayakan investasi menunjukkan bahwa kegiatan pengembangan layak dilakukan. Beberapa strategi pengembangan wisata yang dihasilkan meliputi strategi sosialisasi, strategi pemberdayaan masyarakat, strategi peningkatan tingkat pendapatan secara ekonomi, strategi investor, strategi infrastruktur, serta strategi kebijakan/dukungan kelembagaan.Kata kunci: Analisis Finansial, Pengembangan Wisata, Kesediaan untuk Membayar
STRATEGI PENGEMBANGAN EKOWISATA MELALUI PENINGKATAN PARTISIPASI MASYARAKAT, STUDI KASUS KOMUNITAS KELURAHAN KALIMULYA KOTA DEPOK
Authors: Kurniasari Eva , Rustiadi Ernan , Tonny Fredian
Published: February 2020

Since Depok relatively has limited natural resources, creativities and innovation are needed to develop local potential, such as tourism. Several potential tourism objects are located along Ciliwung Riverside. Moreover, this area was also included in the nature area development plan (Rencana Rinci Tata Ruang Bagian Wilayah Kota VIII Sukmajaya for plan development of 2013. The purpose of this research is to determine the level of community participation and potential development of social and economic activities, and also to analyze existing policies related to tourism development in Depok City. Methods used were interviews, observation and questionnaire. Stratified random sampling was applied to 30 respondents grouped by the education level and the work type. Data obtained were tabulated and analyzed descriptively by chi square. Formulation of strategies and policies for the development of ecotourism programs in this study were analyzed using the Analytical Hierarchy Process (AHP). Results showed that the level of community participation in research location was on the first ladder of Non-Participation and the second ladder of Tokenism on Arnstein's theory. Formulations of tourism development strategy are focused in enhancing the society capacity, regional arrangements, financing, infrastructure development, institutional development and also marketing.Keywords: Ecotourism, Community Participation, Depok CityABSTRAK Sumberdaya alam di Kota Depok relatif terbatas sehingga diperlukan kreativitas dan inovasi untuk mengembangkan potensi lokal, misalnya pariwisata. Beberapa obyek wisata yang berpeluang untuk dikembangkan menjadi sarana rekreasi berada di daerah sempadan Sungai Ciliwung, yang berdasarkan Rencana Rinci Tata Ruang Bagian Wilayah Kota VIII Sukmajaya pada rencana pemanfaatan Tahun 2013 merupakan salah satu wilayah rencana pengembangan nature area. Penelitian bertujuan untuk mengetahui tingkat partisipasi masyarakat, jenis kegiatan sosial dan ekonomi yang dapat mendukung ekowisata, serta menganalisis proses kebijakan yang sudah ada terkait dengan pengembangan ekowisata di Kota Depok. Metode penelitian dilakukan dengan wawancara, observasi dan kuesioner. Sampling dilakukan secara purposive pada 30 responden yang dikelompokkan berdasarkan tingkat pendidikan dan jenis pekerjaan. Data kemudian ditabulasi dan dianalisis secara deskriptif serta diuji dengan chi square. Perumusan strategi dan kebijakan guna pengembangan program dilakukan menggunakan analisis Analytical Hierarchy Process (AHP). Hasil penelitian menunjukkan bahwa tingkat partisipasi masyarakat di lokasi penelitian berada pada tangga pertama Non Participation dan tangga kedua Tokenism berdasarkan Teori Arnstein. Rumusan strategi pengembangan kawasan ekowisata diprioritaskan pada peningkatan kapasitas masyarakat, penataan kawasan, pembiayaan, pengembangan sarana prasarana, pengembangan kelembagaan serta pemasaran.Kata kunci: Ekowisata, Partisipasi Masyarakat, Kota Depok