bluuebunny/crossref_metadata_2025 huggingface dataset:
Cancer of nasopharynx in young patients
Authors: Morales Pedro , Bosch Antonio , Salaverry Santiago , Correa Jose N. , Martínez Isidro
Published: February 2007

From 1961 to 1980 17 patients with nasopharyngeal carcinoma who were less than 30 years old at time of diagnosis were treated at the two oncologic hospitals in Puerto Rico. Fourteen of the tumors were lymphoepitheliomas and the remaining three were anaplastic carcinomas. Ninety‐four percent of the patients were found to have neck adenopathy at the initial examination and in 65% of them the adenopathy was bilateral. The 5‐year actuarial survival was 14. The main cause of failure was the distant metastasis. Seventy‐one percent of our patients developed distant metastasis sometime during the course of their disease.

Carcinoma of the nasopharynx is uncommon in Puerto Rico as in other western countries. The post‐adolescent age incidence peak reported from different countries is also present among Puerto Ricans.
Streptococcus bovis subacute bacterial endocarditis as a presenting symptom of occult double carcinoma of the colon
Authors: Trajber I. , Solomon A. , Michowitz M. , Yust I.
Published: February 2007

A case of double carcinoma of the colon is presented in association with subacute bacterial endocarditis due to Streptococcus bovis. The presence of Streptococcus bovis septicemia is a strong pointer in favour of associated colon carcinoma even in the absence of gastrointestinal symptomatology.
A new tumor imaging agent‐111In‐bleomycin complex. Comparison with 67Ga‐citrate and 57Co‐Bleomycin in tumor‐bearing animals
Authors: Hou De‐Yan , Hoch Hans , Johnston Gerald S. , Tsou K. C. , Jones Alfred E. , Miller Elizabeth E. , Larson Steven M.
Published: February 2007

We have found a new 111In‐bleomycin complex (BLMC), which has high affinity to tumor, does not bind to transferrin and is stable in vivo. Distribution in animals bearing glioma, hepatoma, or mammary adenocarcinoma at 48 hours showed: the ratios of tumor to blood, brain, heart, lung, liver, pancreas, stomach, and femur were 1.4‐22.4 times as high for 111In‐BLMC as for 67Ga‐citrate. In mammary adenocarcinoma, 111In‐BLMC bound more to viable and 57Co‐Bleomcyin (BLM) more to necrotic tumor. In viable tumor, the concentration of 111In‐BLMC was similar to that of 57Co‐BLM. The ratios of tumor to stomach and pancreas were higher, to blood, brain, muscle, heart, and femur were lower for 111In‐BLMC than those for 57Co‐BLM. The ratios of tumor to lung, liver, spleen, skin, and kidney were similar for the two compounds. Tumors were imaged more distinctly with the new 111In‐BLMC and 57Co‐BLM than with 67Ga‐citrate. 111In‐BLMC is promising for tumor imaging.
Colocutaneous fistula complicating tenckhoff catheter placement for intraperitoneal chemotherapy
Authors: Wakefield T. , Eckhauser F. , Strodel W. , Knol J.
Published: February 2007

In view of the characteristic intra‐abdominal spread of carcinoma of the colon and rectum [1‐3], the use of intraperitoneal chemotherapy may offer an alternative to intravenous or oral drug therapy and even radiation therapy for recurrent disease [4,5]. Several investigators have demonstrated that intraperitoneal drug administration may result in portal vein levels ten to 20 times higher than those observed in peripheral venous blood samples [6]. Traditionally, intraperitoneal chemotherapy has been administered through the Tenckhoff catheter system which was originally developed for peritoneal dialysis in patients with acute or chronic renal failure [7,8]. We report a case of Tenckhoff catheter erosion into the colon with subsequent fistulization developing 20 days after intra‐operative placement for intraperitoneal or “belly bath” chemotherapy; this complication occurred in a patient with locally recurrent colorectal adenocarcinoma in whom pelvic peritoneal implants without hepatic metastases were identifed at reoperation. This complication of the Tenckhoff catheter system has not previously been reported in the surgical literature.
Effect of Variation of Drug Dosage on Disease Control and Regional Toxicity in Prophylactic Perfusion for Stage I Extremity Melanoma
Authors: Mikhail Raouf A. , Boddie Arthur W. , Ames Frederick C. , Zimmerman Stuart O. , McBride Charles M.
Published: February 2007

One hundred and fifty‐six patients with extremity melanomas of known level or thickness who were perfused prophylactically with l‐phenylalanine mustard (1‐PAM) between January 1974 and December 1978 were studied retrospectively to determine the effect of variation of drug dosage and temperature on regional toxicity and disease control. The median drug dosage of 1‐PAM for 57 patients undergoing axillary perfusion was 0.85 mg/kg (range 0.48‐1.0 mg/kg) and the median dosage was 1.2 mg/kg (range 0.59‐1.69 mg/kg) for 99 patients undergoing iliac perfusions. Sixty‐five percent of patients achieved a maximum skin temperature of between 101d̀ and 102°F during perfusion. Determinate survival in the entire group was 93% at 5 years; 10% of patients developed positive regional nodes; and 2.5% developed local or intransit metastases. Based on analysis of other series of patients with extremity melanoma with equivalent Clark's level 5‐year determinate survival might be expected to be between 65 and 80%. The expected incidence of nodal metastases should be 19.1‐24.0% and the incidence of local and intransit metastases should be 3‐6%. While this series suggests a survival advantage for a series of extremity melanomas treated by regional chemotherapy when compared to other series treated by wide excision ± regional node dissection, the results obtained were independent of dosage of drug administered or maximal temperature attained over the range studied. This suggests consideration be given to exploring other dose ranges of drugs and heat in an effort to achieve equivalent control with lower regional toxicity.
Granular cell tumor of the appendix
Authors: Sarma Deba P. , Simmons Gary T. , Rodriguez Fred H. , Weilbaecher Thomas G. , Love Gordon L.
Published: February 2007

A case of granular cell tumor of appendix occurring in a 58‐year‐old man is described and the literature is reviewed.
Plasma cell granuloma of the tonsil
Authors: Weilbaecher Thomas G. , Sarma Deba P.
Published: February 2007

Plasma cell granuloma (inflammatory pseudotumor) has been described most commonly in the lung. Review of the English literature fails to reveal occurrence of such a lesion in the tonsil. We are reporting such a case presenting as a unilateral tonsillar mass in a 63‐year‐old man. A more typical case of plasma cell granuloma of lung is also presented to illustrate the similarity between the tonsillar and pulmonary lesions.
Nonfamilial Turcot's syndrome associated with Turner's syndrome, multiple carcinomas of the tongue, and cancer of the colon
Authors: Herrera‐Ornelas Lemuel , Ochi Hisako , Petrelli Nicholas , Mittelman Arnold , Sandberg Avery A.
Published: February 2007

Herein we present the clinical and cytogenetic data of a patient with Turner's and Turcot's syndrome associated with multiple carcinomas of the tongue and cancer of the colon.
Pedunculated primary hepatocellular carcinoma
Authors: Cunningham Peter L. , Nava Hector , Lopez Cecilia , Douglass Harold O.
Published: February 2007

A case report and two additional cases of pedunculated, primary hepatocellular carcinoma (PHCC) are added to those previously reviewed, and are compared with the more typical presentations of PHCC. Distinct differences include lesser associations with hepatitis B and alpha fetal protein among the pedunculated lesions. More importantly, this unique form of PHCC carries a much higher resectability rate that hopefully can be translated into longer survival in this subgroup.
Surgery for carcinoma of the pancreas and periampullary structures: Complications of resectional and palliative procedures
Authors: Lee Yeu‐Tsu N.(Margaret)
Published: February 2007

This is a retrospective review of 237 patients who had surgical exploration for proven or suspected malignant lesions of the pancreas (201 patients) and periampullary structures (36 patients). Among the former group, 128 patients had carcinoma diagnosed at initial operation (31 by resected specimens, 33 by liver, and 64 by other biopsies), four patients had Whipple resection for suspected carcinoma of pancreas but specimen showed chronic pancreatitis, and 69 patients had suspected carcinoma of the pancreas without histological proof. Among patients who had Whipple resections, the operative mortality was 20%. Over 40% of the deaths was due to systemic complications. Among patients with unresectable lesions, 19% died postoperatively. This figure correlated more with the condition of the host and the extent of the tumor rather than with the specific operative procedures: The operative mortality was 16‐18% for those who had either biliary or duodenal bypass, 11% for those who had both type of bypass procedures, and 36% for those who did not have any bypass performed. Although near 60% of the death was secondary to advanced state of the malignant condition, some death could have been delayed or altered by more optimal biliary, duodenal decompression, and added therapy to decrease gastric acid. In patients with unresectable carcinoma of the head of the pancreas, the most optimal palliative procedures appear to be choledochojejunostomy constructed with a side‐to‐side anastomosis between common or hepatic bile duct and a loop of jejunum, supplemented with an enteroenterostomy below the biliary anastomosis, and a high gastrojejunostomy as a therapeutic or prophylactic treatment of duodenal obstruction.
Dermatofibrosarcoma non‐protuberans: Description and report of five cases of a morpheaform variant of dermatofibrosarcoma
Authors: Clark Lambert W. , Abramovits William , Gonzalez‐Sevra Aldo , Souchon Eduardo , Schwartz Robert A. , Little Walter P.
Published: February 2007

Five cases of dermatofibrosarcoma are reported. All showed features typical of dermatofibrosarcoma protuberans except that in four cases, and a portion of the fifth case, no protusion of the tumor was noted clinically despite the rather advanced stage of growth of the tumor. These lesions resembled morphea or a morpheaform basal cell carcinoma clinically but could be recognized as “dermatofibrosarcoma non‐protuberans” by physicians who had observed a previous case.
The continuing problem of carcinoma of the pancreas
Authors: Parker George A. , Postlethwait R. W.
Published: February 2007

The courses of 208 patients with adenocarcinoma of the pancreas were reviewed. The lesion was located in the head of the pancreas in 142 patients, (68%) and of these, in 22 patients the diagnosis was confirmed histologically at postmortem examination; 21 patients underwent laparotomy and biopsy with a 33% operative mortality and 3.4‐month average survival; 89 patients underwent biliary and/or gastric bypass with a 24% mortality and 4.8‐month average survival; 10 patients underwent pancreaticoduodenectomy with a 20% mortality and 14.6‐month average survival. The lesion was located in the body or tail of the pancreas in 77 patients (32%); and, of these, 15 patients had histologic confirmation of clinical diagnoses at postmortem examination; 19 patients underwent biopsy of extra‐abdominal metasases and survived an average of 1.4 months; 27 patients underwent laparotomy and biopsy with a 26% operative mortality and 3.5‐month average survival; 4 patients underwent gastric and/or biliary bypass with a 50% mortality and 4.5‐month average survival; one patient underwent noncurative distal pancreatectomy and survived 1 month postoperatively. No patient was cured of his disease. Of the 55 operative survivors of biliary bypass alone for carcinoma of the head of the pancreas, 5 (9%) required subsequent gastroenterostomy for duodenal obstruction.
Total pelvic exenteration for advanced carcinoma of the lower colon
Authors: Takagi Hiroshi , Morimoto Takeshi , Yasue Mitsunori , Kato Kimiyuki , Yamada Eikichi , Suzuki Ryoji
Published: February 2007

Thirteen patients with advanced carcinoma of the lower colon and no evidence of extrapelvic metastasis were submitted to total pelvic exenteration. Nine of the 13 patients had ureteral urinary diversion by the ileal segment conduit. Three had colonic conduit bladder using the terminal portion of the descending colon. One patient had bilateral uretero colonic anastomosis. The operative mortality rate was 7.7%. Determinate 5‐year survival rate of 38.5% was achieved. Histological examinations of the surgical specimen revealed associated abcesses adjacent to the tumor in six cases, although the cancer extended to the bowel wall and adhered to the surrounding structures in all specimens. Total pelvic exenteration assures a better quality of life, lessening of symptoms, disease control and, in selected patients, a cure.
Coexistence of aldosteronoma and pheochromocytoma in an adrenal gland
Authors: Wajiki M. , Ogawa A. , Fukui J. , Komiya I. , Yamada T. , Maruyama Y.
Published: February 2007

An extremely rare case is reported in which aldosteronoma and pheochromocytoma coexisted in an adrenal gland. Although the patient presented with clinical features of primary aldosteronism, preoperative examination showed an elevation of both plasma aldosterone and urinary catecholamines. Histology of the removed adrenal gland revealed that, concurrently with a round mass of adrenocortical adenoma, the adrenal medulla was totally occupied by the typical structure of pheochromocytoma.
The steroid hormone receptors in tumors of adipose tissue
Authors: Chaudhuri P. K. , Walker M. J. , Beattie C. W. , Das Gupta T. K.
Published: February 2007

The clinical evidence suggests that the steroid hormones may influence the biologic course of tumors of soft tissue. In an attempt to characterize the possible steroid hormone dependency of soft tissue, we studied the incidence and distribution of cytosolic receptors for the steroid hormones in benign and malignant tumors of adipose tissue origin. All specimens were assayed for the steroid hormone receptors by charcoal dextran technique and analyzed by the method of Scatchard. The results show a high incidence of cytosolic estrogen and glucocorticoid receptors in tumors of adipose tissue origin except in lipoma and well differentiated liposarcoma. The binding parameter of these receptors suggests that the receptors may be responsive to physiologic steroid hormonal milieu.
Thyroid nodules in the irradiated patient—An indication for total thyroidectomy
Authors: Segal Robert L. , Cobin Rhoda H. , Futterweit Walter , Fiedler Robert P. , Sirota David K.
Published: February 2007

Eight patients who received radiation therapy to the head, neck, or chest during infancy, childhood, or adolescence are reported. In these individuals, the presenting abnormality was a nodule of the thyroid gland, which was found to be benign at surgery. All patients were subsequently found to harbor a malignant lesion of the contralateral lobe. On the basis of this study and the discussion presented, we feel that a total thyroidectomy is the indicated therapeutic procedure in previously radiated patients presenting with a cold nodule.
Postirradiation soft tissue sarcoma occurring in breast cancer patients: Report of seven cases and results of combination chemotherapy
Authors: Kuten Abraham , Sapir Dov , Cohen Yoram , Haim Nissim , Borovik Riva , Robinson Eliezer
Published: February 2007

Seven cases of soft tissue sarcoma developing after primary or postoperative radiotherapy for breast carcinoma are reported. The sarcomas occurred within the irradiated volume, after a latent period of 4‐26 years. These cases conform well to established criteria for the diagnosis of radiation‐induced sarcoma. Chemotherapy, consisting of the four‐drug combination CYVAD1C (cyclophosphamide, vincristine, adriamycin, DTIC) was employed in six of the seven patients. Only two of them achieved partial remission, lasting only 2 and 3 months, respectively. The effectiveness of adriamycin‐containing chemotherapy regimens in soft tissue sarcomas as well as the remote hazard of radiation‐related sarcoma in primary or postoperative breast irradiation are discussed.
Amsacrine and etoposide induced paralytic ileus in a patient with acute myelomonocytic leukemia
Authors: Kucuk Omer , Apostol James V.
Published: February 2007

A 73‐year‐old man with acute myelomonocytic leukemia developed a severe paralytic ileus after amsacrine and etoposide treatment. The ileus did not respond to treatment with gastric suction and intravenous fluids. Autonomic neuropathy induced by anti‐neoplastic drugs may lead to this life‐threatening condition.
Early recurrence following induction chemotherapy for stage IV head and neck cancers: Rationale for additional therapy
Authors: O'Donnell Margaret R. , Mohr Rose M. , Baxter Donald H.
Published: February 2007

Twenty patients with Stage IV neoplasms of the head and neck were treated with two induction cycles of cis‐platinum, bleomycin and metho‐trexate. Eight of eleven operable patients and five of nine inoperable patients responded prior to surgery and/or radiation, including three CRs. Toxicity was mild. There were two early local recurrences but no systemic metastases among the resectable patients. Perhaps initial therapy should be used to select patients with chemoresponsive tumors who might benefit from additional chemotherapy after surgery.
Creatine kinase isoenzyme (CK‐BB) by RIA as a follow‐up marker in stage D cancer of the prostate: Comparison with PAP RIA
Authors: El‐Shribiny Ayda , Bharvaga Arvind , Fitzpatrick John , Murphy Gerald P.
Published: February 2007

Fifty‐nine patients with stage D carcinoma of the prostate under different modalities of treatment were studied for creatine phosphokinase isoenzyme BB (CK‐BB) and prostatic acid phosphatase (PAP) levels in serum by radioimmunoassay (RIA) technique, in order to study the possible use of CK‐BB as a follow‐up marker compared to PAP. Thirty‐three patients were in stable, 19 in progressive, and seven in regressive clinical state. CK‐BB was above normal level in 52 (88%) out of 59 patients with no statistically significant difference between the three clinical states. On the other hand, PAP was above normal level in only 23 patients (38.98%) with statistically significant difference between the three clinical states (P < 0.001).

The PAP/CK‐BB index was below 1 in stable and regressive condition, while it was above 1 in eight out of 19 patients with progressive disease. The PAP/CK‐BB index may be of prognostic importance. CK‐BB by RIA was abnormal in more cases than PAP. In this way CK‐BB reflects the presence of the tumor and may be used for diagnosis; however, it does not reflect the clinical response as PAP does.
Diagnosis and operation for locally recurrent rectal cancer
Authors: Takagi Hiroshi , Morimoto Takeshi , Kato Tomoyuki , Yasue Mitsunori , Hara Suguru , Suzuki Ryoji
Published: February 2007

Local recurrence of rectal cancer following abdominoperineal resection is rarely amenable to limited resection. Six patients with deeply invading recurrent lesions had pelvic exenteration combined with sacral resection. This procedure seems a reasonable treatment for palliation and the chance of cure in selected patients. In order to select good candidates for this extensive procedure, carcinoembryonic antigen (CEA) assays and the diagnosis of locally recurrent tumor with pelvic computed tomography (CT) were evaluated. CEA assay is valuable for diagnosing most recurrent rectal cancers, but it is inadequate for early detection. A high CEA level often indicates extrapelvic tumor spread. CT examination is very valuable for the early detection and localization of recurrence in relation to pelvic structures.
Cardiac tamponade in lung cancer
Authors: Gilkey Susan , Reyes Cesar V.
Published: February 2007

Neoplastic cardiac tamponade is extraordinary and dramatic as an initial presentation of cancer and not so unusual as a late complication. Five clinically and microscopically confirmed cases of cardiac tamponade as the first manifestation of pulmonary adenocarcinoma are reported along with a review of pertinent literature.
Hemangioendothelioma of the lymph node: A case report
Authors: Goldstein Jed , Bartal N.
Published: February 2007

Primary benign vascular tumors of lymph nodes are very rare. Various forms of lymph nodal vascular transformations defined as hemangiomatoid lesions, pannodal vasodilatation, or nodal anigiomatosis have been described. We present a patient who was thought to have an epithelial salivary gland tumor, but instead was found to have an hemangioendothelioma of an adjacent enlarged lymph node in the region of the left submandibular gland.
Hartmann's pouch carcinoma
Authors: Lafreniere Rene , Ketcham Alrefd S.
Published: February 2007

Since 1921, when Henry Hartmann first described his procedure for rectal carcinoma, multiple modifications of the original technique have been proposed. However, the basic principle of a rectal pouch has always been retained. Two cases of carcinoma developing in such a pouch are described; both occurred years after creation of the pouch. One was managed by local resection through a transsacral approach; the other required an abdominoperineal resection. Consideration must be given to careful examination and sigmoidoscopy of these pouches as they tend to be forgotten by the physicians due to their hidden location.
Discrepancy in ER levels of breast carcinoma in biopsy vs mastectomy specimens
Authors: Young Shun C. , Burkett Richard Jerry , Stewart Charles
Published: February 2007

The presence of estrogen receptors (ER) in breast tumors has been used by many as the major indicator for hormonal treatment of breast cancer. However, multiple factors have been shown to be involved in determining the hormone dependence of breast cancer. This paper reports another factor that influences the accuracy of ER determination. From January 1977 through December 1983 fifty‐eight (58) of these patients had ER determination of both biopsy and mastectomy specimens. Of the 31 patients that remained ER positive in mastectomy specimen, 13 had significantly lower ER levels (by at least 50%) from the mastectomy specimens. These findings indicate that ER status is greatly influenced by the source of the specimen.
Calcitonin as a tumor marker for nonthyroid neoplasia
Authors: Hom David , Waxman Kenneth
Published: February 2007

Plasma levels of calcitonin have been utilized as a tumor marker for medullary carcinoma of the thyroid. Elevated calcitonin levels have been noted with other tumors as well. The present case documents a marked decrease in calcitonin levels following therapy for breast carcinoma, supporting further evaluation of calcitonin as a clinically useful tumor marker for nonthyroid neoplasm.
Bronchial adenoma: Surgical experience with long‐term follow‐up (4–17 years)
Authors: Halevy Ariel , Schachner Arie , Nili Moshe , Spitzer Shimon , Deviri Ehud , Levy Morris J.
Published: February 2007

Of 16 patients with bronchial adenoma who were operated on at Beilinson Medical Center from 1967 to 1980, only three presented the “triad” of cough, hemoptysis, and recurrent pulmonary infections. In two patients the tumor was diagnosed incidentally and in five patients histological evidence of adenoma was made during bronchoscopy. One patient died of myocardial infarction following reoperation for bleeding, and one patient was lost to follow‐up. The remaining 14 patients were followed for 4 to 17 years without evidence of local recurrence or distant metastases.

We conclude that the long‐term prognosis of patients with bronchial adenoma is excellent, and limited surgical procedure should be the treatment of choice whenever possible.
Use of 111in‐bleomycin for combining radiotherapy and chemotherapy on glioma‐bearing mice
Authors: Hou De‐Yan , Hoch Hans , Johnston Gerald S. , Tsou K. C. , Farkas Raymond J. , Miller Elizabeth E.
Published: February 2007

Mice bearing transplanted glioma received 0.9% NaCl, 0.1 mg of BLM, or 200–250 μCi of 111 In‐BLM (0.1 mg BLM) daily for 5 days intraperitoneally. After therapy, tumor sizes were in the order NaCl > BLM > 111 In‐BLM. On the 11th day after the first injection, tumor size (mm3) in the 111 In‐BLM group was 1,220; in the BLM group, it was 2,310 (P < .025). After intratumor injection of a total dose of 0.1 mg of BLM/gm tumor weight, or of 1 mCi/gm tumor weight of 111 In‐BLM (carried by 0.1 mg of BLM/gm tumor weight), the tumor size decreased in the 111 In‐BLM group more than in the BLM group. On the 5th day after the 2nd dose therapy, the tumor size in the 111 In‐BLM group was 2,020; in the BLM group it was 4,220 (P < .05). Host weights for these two groups were similar. The necrotic area in the tumor was much greater in the 111 In‐BLM group than in the BLM group. These results suggest the use for radiotherapy and chemotherapy.
Variability of heating patterns in animals by magnetic induction hyperthermia
Authors: Storm F. Kristian , Christensen Douglas A. , Olch Arthur J. , Silberman Allan W. , Roe Denise J. , Harrison William H. , Elliott Robert S. , Morton Donald L.
Published: February 2007

In a test of electromagnetic induction hyperthermia to deep viscera of a live dog model, we found that heating was not uniform to any depth, but was quite variable. In general, there was a thermal gradient between peripheral and central portions of the transposed spleen of about 1°C. Though heat generation within the abdomen was not uniform, its temperature pattern in the alive animal resulted in significant heating of that part of the organ that had been surgically placed at the center of the animal. This heating could not be explained by perfusion with regionally heated core blood. Our results indicate that extensive investigations in living systems and complex dynamic phantoms will be necessary before individual patient response can be predicted.
Carcinoma arising in burn scar
Authors: Sarma Deba P. , Weilbaecher Thomas G.
Published: February 2007

A 60‐year‐old man had undergone a left below‐knee amputation 30 years ago owing to trauma and burn suffered in a dynamite explosion. He has been wearing an artificial leg since then. He developed a squamous cell carcinoma on the amputation stump 30 years later. The possible relationship of the burn scar and chronic irritation by the artificial leg to the cancer is discussed.
Adrenal adenocarcinomas: Histologic grading and survival
Authors: Karakousis C. P. , Rao U. , Moore R.
Published: February 2007

Thirty‐eight patients with adrenal adenocarcinoma were reviewed. Two of 23 males and 8 of 15 females had a functioning tumor (P < 0.005). The most striking finding in this review was the variation in survival according to histologic grade. The median survival from histologic diagnosis was for grade I tumors 54 months, for grade II tumors 26 months, for grade III tumors 1 month. The difference in survival between patients with grade I or II tumors and those with grade III tumors was significant (P < 0.001). The majority of the patients with grade III tumors were admitted with clinical evidence of disseminated disease and died within 1 month. Among the patients with well‐differentiated tumors, five who received surgical treatment of their recurrence had a median survival of 51 months, whereas seven patients who received no surgical treatment had median survival of 20 months following first recurrence (0.05 < P < 0.10).
Identical laryngeal cancers in two nontwin sibling pairs: Case reports and a review of the literature
Authors: Sener Stephen F. , Spiro Ronald H. , Shah Jatin P.
Published: February 2007

The occurrence of identical laryngeal cancers in two nontwin sibling pairs is reported for the first time. To understand the relative importance of genetic and environmental factors in the etiology of laryngeal cancer, the evidence in the literature for the development of identical cancers in genetically unrelated and related pairs sharing the same environments was examined.
Carcinoma arising in fibroadenoma: Case report and review of the world literature
Authors: Yoshida Yoshiyuki , Takaoka Mitsuka , Fukumoto Manabu
Published: February 2007

To date 119 cases of “carcinoma arising in a fibroadenoma” have been reported in the world literature. A total of 120 cases, including the case described here, are analyzed. The mean age of the affected females was 43 years. A few patients complained of several disorders other than breast tumor before and during the development of the tumor. The tumor was most frequently located in the upper outer quadrant of the breast. Most carcinomas in fibroadenomas were lobular carcinoma in situ followed by duct carcinoma in situ. There was only one squamous cell carcinoma. The malignant process was confined to the fibroadenoma in over half of the cases. In some cases additional foci outside the fibroadenoma were reported. Radical mastectomy was the most frequent treatment. The prognosis was usually good.
Treatment of perineural metastasis from squamous carcinoma of the skin with aggressive combination chemotherapy and irradiation
Authors: Loeffler Jay S. , Larson David A. , Clark John R. , Weichselbaum Ralph R. , Norris Charles M. , Ervin Thomas J.
Published: February 2007

Perineural metastasis from squamous cell carcinoma is quite rare. The treatment of such metastasis in the head and neck region is difficult due to base of skull or intracranial involvement by tumor. Surgery and radiotherapy may provide local control, but patients often fail distantly. We present a patient with squamous cell carcinoma presenting with perineural metastasis who was successfully treated with combination chemotherapy and definitive radiation therapy. Suggestions of therapeutic management are made of this uncommon clinical problem.
Evidence for a hepatic‐renal antagonism in the production of hepatic erythropoietin in a phenylhydrazine‐induced compensated hemolytic state in the rat
Authors: Dornfest Burton S. , Naughton Brian A. , Lapin David M. , Gordon Albert S.
Published: February 2007

A compensated hemolytic state was induced in rats by injection of phenyl‐hydrazine (PHZ) over a 6‐week period. The liver and kidney were perfused to determine the levels and time of appearance of a hepatic erythropoietic factor (HEF) which induces the production of hepatic erythropoietin (Ep) and its antagonist, a renal inhibitory factor (RIF). Erythropoietin assays on the perfusates have been previously reported. The amount of HEF in perfusates recovered from the livers of the PHZ‐treated rats was significantly higher during the 4th to 5th weeks of treatment, coinciding with the time of increased liver production of Ep. During the 6th week of PHZ treatment, the titer of RIF in perfusates recovered from the kidney was markedly increased and the HEF titer was decreased to near the control level, suggesting an inhibitory action of RIF on HEF synthesis and/or effect. These findings indicate that an HEF/RIF control mechanism regulates hepatic Ep production in this compensated hemolytic condition.
Early onset of tetany following thyroidectomy: Report of two cases
Authors: Scanlon Edward F. , Sener Stephen F. , Murphy E. Dennis
Published: February 2007

The most common complication of total thyroidectomy is hypocalcemia. Following thyroidectomy, especially total thyroidectomy, the serum calcium usually falls gradually and patients do not usually require supplementary medication before 24 hours. Two cases of total thyroidectomy are presented in which the preoperative serum calcium levels were normal and hypocalcemic tetany developed in the recovery room immediately after the operation. The hypocalcemia was a temporary phenomenon, and neither patient requires supplementary calcium at the present time. There is no good explanation for this precipitous drop in the serum calcium levels in these two patients.
Carcinosarcoma of the gallbladder: Report of a case
Authors: Lopez Gloria E. , Strimel William , Herrera‐Ornelas Lemuel
Published: February 2007

Carcinosarcomas of the gallbladder are rare tumors characterized by malignant epithelial and mesenchymal components that grow intermingled into each other. Herein we present a case that illustrates the difficulties in the diagnosis and the clinical management of this entity.
The selected use of ultrasound mammography to improve diagnostic accuracy in carcinoma of the breast
Authors: Frazier Thomas G. , Murphy J. Thomas , Furlong Ayn
Published: February 2007

Our initial experience with diagnostic ultrasound mammography (UM) showed it to be of high diagnostic accuracy and improved specificity when compared with x‐ray mammography (XRM) in certain categories of patients. To evaluate this modality further, we reviewed our experience with 600 consecutive patients who underwent ultrasound mammography as part of their initial evaluation for breast disease. Five categories of patients were reviewed: I: age 35 or less—129; II: DY or P‐2 pattern on XRM—174; III: negative XRM but symptoms requiring additional evaluation—81; IV: high risk remaining breast in patients previously having mastectomy—48; V: refusal of repeat XRM because of pregnancy, lactation, or fear of radiation exposure—168.

Fifty‐five solid lesions were diagnosed, including 36 carcinomas. Seventeen of these were not diagnosed on x‐ray mammography, giving an improved pick‐up of carcinoma in this overall group of 2.83%. Of particular interest was that, of the 27 carcinomas that were found in the group having XRM, 8 or 29.6% were missed on that modality alone. Five of these (62.5%) were patients having a DY pattern. All patients have been followed carefully and re‐examined at 3‐month intervals, with no evidence of a false negative examination. Overall, we feel diagnostic ultrasound mammography is a valuable adjunct to x‐ray mammography and recommend its continued use in selected groups of patients where it has a superior diagnostic accuracy over x‐ray mammography alone.
Paget's disease of the breast presenting as a cutaneous horn
Authors: Dabski Krzysztof , Stoll Howard L.
Published: February 2007

A 67‐year‐old woman developed a cutaneous horn on the nipple of her right breast. Biopsy of the skin underlying the horn disclosed Paget's disease of the breast. An intraductal adenocarcinoma of the same breast was found on mastectomy. High index of suspicion is mandatory in evaluating all nipple lesions.
Biochemical and hematological tests in patients with breast carcinoma: Correlations with extent of disease, sites of relapse, and prognosis
Authors: Lee Yeu‐Tsu N. (Margaret)
Published: February 2007

The value of serial biochemical and hematological tests of blood in differentiating stages and in detecting recurrence of breast carcinoma was studied in 500 patients. Patients who had mastectomy and were with no evidence of disease (NED group) had higher hemoglobin, albumin, total protein, and lower LDH than patients with any amount of breast carcinoma. These four tests became more abnormal in patients with metastatic disease (group IV). In addition, peripheral lymphocyte count was significantly decreased, and SGOT, AP, alpha‐1 globulin, and CEA significantly increased, when patients developed recurrent or metastatic disease. Patients with disseminated soft tissue or lung metastasis had less abnormality of such blood tests than those with metastasis in bone or other visceras. Immunoglobulins (IgG, IgA, IgM) were not different between early or late stages, nor specific sites of metastatic involvement. Among patients with a greater amount of loco‐regional disease (group III) and patients with metastatic disease (group IV), those who had hemoglobin ⩾ 12.5 gm%, lymphocyte count of 15–2,500/cmm, albumin ⩾ 4 gm%, AP ⩽ 25 units, or LDH ⩽ 400 units had significantly better 5‐year survival rates.
Isolation of tumoricidal human factors from lymphoid cells and enzymatic digestion of these factors into small fragments retaining tumoricidal effects
Authors: Cameron Deborah J.
Published: February 2007

Gel filtration and immunoadsorption techniques have been utilized to purify tumoricidal factors from sturgeon sera as well as human plasma. Two pure proteins with cytotoxic activity were isolated from the sturgeon serum (factors A2 and B2) and two additional cytotoxic factors were isolated from human plasma (Factors A and B). In another study, human factors A and B were quantitiated in both normal donor and cancer patients' plasma. It was found that the cancer patients produced at least 50% less tumoricidal factors than did the normal donors. Furthermore, when the secretions from various lymphoid cell populations were purified utilizing immunoadsorbent techniques, it was found that the macrophages generally were producing the human tumoricidal factors. Both the sturgeon and the human factors were enzymatically cleaved into several small molecular weight fragments. Sephadex G‐75 column chromatography was then utilized to isolate the enzymatic cleavage fragments. Three fragments with cytotoxic activity were isolated from both sturgeon factor A2 and B2. Similarily, human factor A was digested into two fragments with cytotoxic activity and factor B was digested into three fragments with cytotoxic activity. The molecular weights of the cytotoxic sturgeon and human fragments ranged from 14,000 to 23,000 whereas the intact sturgeon and human factors had a molecular weight slightly greater than 67,000. Ultimately, if these small molecular weight fragments can be sequenced, then it would be possible to prepare a synthetic analog which might have future potential as a mode of treatment for cancer patients.
Malignant mesothelioma of testicular tunica
Authors: Vakalikos I. , Destouni E. , Valassis K. , Eftichiadou C. , Charalambopoulos A. , Salem N.
Published: February 2007

A case of malignant mesothelioma of testicular tunica in a 26 year old male is presented. Operation was followed by local radiotherapy. The patient remains disease free one year after initial diagnosis.
Questionable relationship between cholecystectomy and colon cancer
Authors: Spitz Margaret R. , Russell Nancy C. , Guinee Vincent F. , Newell Guy R.
Published: February 2007

The relationship between prior cholecystectomy and right‐sided colon cancer was evaluated in a case‐control study. The study population comprised 267 women with right‐sided colon cancer (cases) and 268 women with left‐sided colon cancer (controls). All patients were white females, aged between 40 and 69 years, and registered at The University of Texas M.D. Anderson Hospital and Tumor Institute between 1970 and 1982. Thirty cases (11.2%) and 21 controls (7.8%) had documented prior cholecystectomy (odds ratio 1.49, 95% confidence limits 0.83, 2.67). The temporal relationship between cholecystectomy and colon cancer and the presence of diabetes were also evaluated. The authors conclude that there is no significant relationship between prior cholecystectomy and the development of right‐sided colon cancer.
Portal hypertension as an early manifestation of carcinoma of the pancreas
Authors: Lishner Michael , Jutrin Izhak , Dinbar Alex , Ravid Mordchai
Published: February 2007

Massive hematemesis followed by 48 hours the onset of obstructive jaundice in a previously asymptomatic 38‐year‐old male patient. Splenomegaly was the only abnormal physical finding. Esophagoscopy visualized bleeding varices. The liver scan was normal. Dilated intra‐ and extrahepatic bile ducts and a possible retroperitoneal mass were demonstrated by ultrasonography. Laparotomy disclosed the presence of a carcinoma of the head and body of the pancreas that obstructed the common bile duct and the portal vein. This case report should draw attention to the vast spectrum of rare presentations of pancreas carcinoma.
Malignant melanoma appearing in a post‐mastectomy lymphedematous arm: A novel association of double primary tumors
Authors: Bartal Arie H. , Pinsky Carl M.
Published: February 2007

The association of a malignant melanoma appearing as an additional primary tumor in the swollen arm adjacent to a mastectomy for breast cancer is reported. A review of the literature revealed only one similar patient previously reported. In both patients, the melanoma and its metastasis were restricted to the lymphedematous arm, appeared 10 years post‐mastectomy, and responded to therapy. The similarity to Stewart‐Treves syndrome is emphasized. It is suggested that nevi developing in the lymphedematous arm post‐mastectomy should be carefully monitored and excised early whenever indicated.
Hypothesis: Increasingly intensive locoregional treatment of breast cancer may promote recurrence
Authors: Papaioannou Anaxagoras N.
Published: February 2007

Evidence is presented compatible with the hypothesis that the inevitable tissue injury to the breast engendered by mastectomy or primary radiotherapy may in itself be a factor facilitating recurrence through a variety of local, regional, and systemic tumor‐promoting mechanisms. The potential for tumor enhancement appears to be commensurate with the extent of injury and concerns both local and systemic recurrence. The hypothesis lends itself well to experimental testing. If confirmed, it will point to the importance of minimizing any form of tissue injury in the process of treating primary breast cancer, be it by operation or irradiation and curtailing the extent or intensity of both.
Oral contraceptives and prognosis of breast cancer in women aged 35 to 50
Authors: Rosner Dutzu H. , Joy Judyann V. , Lane Warren W.
Published: February 2007

Among 193 breast cancer patients aged 35–50 years, there was no appreciable difference in the extent of disease at diagnosis between 53 oral contraceptive (OC) users and 140 OC non‐users. There was no overall significant difference between OC users and non‐users for either the disease‐free interval (P=.81), metastatic period (P=.41), or survival (P=.79), either alone or when adjusted for stage or family history. The survival rate of OC users of more than 2 years was similar to the survival rate of those of shorter duration ( P=.36). Patients who began the use of OC 10 years or more before diagnosis showed no statistical difference from those beginning more recently (P=.69). Recent OC users within a year of diagnosis had a survival rate similar to that of other users who stopped the pills at least 1 year prior to diagnosis (P=.14). Our data suggest no adverse effects of OC use on the prognosis of breast cancer, regardless of duration of use, latency or recency period.
Adenocarcinoma of the rete testis
Authors: Sarma Deba P. , Weilbaecher Thomas G.
Published: February 2007

Adenocarcinoma of the rete testis is very rare. It is highly malignant with potential of early metastasis. We are reporting such a case occurring in a 34‐year‐old man who remains tumor‐free 7 years after orchiectomy. Another 20 reported cases of such a tumor from the English literature are reviewed.
Comparison of specific red‐cell adherence and immunoperoxidase staining techniques for ABO(H) blood‐group cell‐surface antigens on superficial transitional cell carcinoma of the bladder
Authors: Boileau Michel A. , Cowles Robert S. , Schmidt Karmen L. , Schmidt Waldemar A.
Published: February 2007

The presence or absence of blood‐group antigens have been used to predict the clinical course of patients with superficial transitional cell carcinoma of the bladder. Antigen loss has been associated with neoplastic change. The red‐cell adherence test has been the most widely accepted method of antigen determination, but this technique has inherent weaknesses. Recently, the immunoperoxidase assay has been used to detect antigens on tumor cells. We compared 30 patients using the red‐cell adherence and immunoperoxidase methods on adjacent micro to me cut sections. The red‐cell adherence and immunoperoxidase methods performed similarly (86 %) when assessing antigen presence or absence. However, the immunoperoxidase method was clearly superior in: 1) specificity for antigens on tumor cells and normal internal controls; 2) localization of antigen; 3) demonstration of cellular morphology; 4) increased objectivity of analysis; 5) ease of reproducibility; and 6) cost effectiveness.
Myxoid liposarcoma mimicking fluid density
Authors: Kim Tae Woo , Reyes Cesar V.
Published: February 2007

A case of liposarcoma of the liver capsule initially presenting as massive pleural effusion and ascites is reported. The chest radiograph, computed tomographic scan, and sonogram are emphasized.
Intramyofiber metastasis in skeletal muscle
Authors: Sarma Deba P. , Weilbaecher Thomas G. , Love Cordon L.
Published: February 2007

Malignant epithelial cells were noted within the sarcolemmal sheath of skeletal muscle fibers in a case of recurrent laryngeal carcinoma. Literature is reviewed to evaluate the diagnostic and prognostic significance of this rare intramyofiber skeletal metastasis by cancer cells.
Radiation pneumonitis: A complication resulting from combined radiation and chemotherapy for early breast cancer
Authors: Gez E. , Sulkes A. , Isacson R. , Catane R. , Weshler Z.
Published: February 2007

Described is a patient with early breast carcinoma who developed clinical radiation pneumonitis during primary radiation therapy and concomitant chemotherapy that included prednisone. This syndrome developed three days following abrupt steroid withdrawal. Retrieval of steroids brought complete resolution of the clinical and radiological findings. Although this syndrome is rare, it is recommended that steroid therapy in a patient previously irradiated to the chest be avoided.
Adenoid cystic carcinoma of bartholin's gland: Review of the literature and report of two cases
Authors: Abrao Fauzer S. , Marques Americo F. , Marziona Francisco , Abrao Mauricio S. , Junqueira Luis C. Uchoa , Torloni Humberto
Published: February 2007

Two patients with adenoid cystic carcinoma of Bartholin's gland and a review of the relevant literature are presented. With the inclusion of these two patients, there are now 24 cases reported. Both patients had large vulvar masses with a short clinical history, and several local tumor recurrences within the first 2½ years after radical vulvectomy. The characteristic cribriform pattern and perineural involvement in addition to vascular invasion were present in the pathological material. No metastases were found in the inguino‐femoral lymph nodes removed. Both patients are alive, without evidence of local recurrence but with lung metastases. A chemotherapeutic treatment scheme (adriamycin and cyclophosphamide) is underway but it is too early to evaluate its results.
Differentiation of jaundice in infancy: An application of radionuclide biliary studies
Authors: Johnston Gerald S. , Rosenbaum Richard C. , Hill J. Laurance , Diaconis John N.
Published: February 2007

Atresia and hypoplasia of the bile ducts are the most common congenital biliary anomalies of clinical importance. Surgical correction can help about 10% of these infants. However, surgery should be performed within the first month of life to avoid irreversible liver parenchymal changes. It is difficult to separate the surgical condition, biliary atresia, from conditions in which the trauma of laparotomy should be avoided, such as neonatal hepatitis and other clinically indistinguishable causes of obstructive jaundice. Radionuclide imaging with the 99mTc‐labeled N‐substituted iminodiacetic acids (HIDA, PIDIDA, DISIDA, etc) have been helpful in the differential diagnosis of biliary atresia.