bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy of silver and gold nanoparticles obtained from vermiwash: In vitro study on antimicrobial and antidiabetic activities
Authors: Rathinam Latha , Sevarkodiyone S. P. , Pandiarajan J.
Published: December 2021

Emerging nanobiotechnology has provided innovative techniques to synthesize nanoparticles through biological methods to explore the potentialities of biological sources like phytoextracts, microbes, animal secretions and excretion. This research studies the potential of vermiwash to synthesize the silver and gold nanoparticles and evaluate its in vitro effect of antimicrobial   and antidiabetic activities. The characterization of the nanoparticles was analyzed through various techniques. Ultraviolet (UV)-Visible spectroscopy showed the maximum absorption spectrum at 413 nm for silver and 541 nm for gold nanoparticles. Fourier transform infrared spectroscopy (FTIR) revealed the reducing agent involved in nanoparticles synthesis. Scanning electron microscope (SEM) images revealed the size of the silver and gold nanoparticles as 24 nm and 50 nm, respectively. Energy dispersive X-ray (EDAX) analysis revealed the elemental composition of the synthesized nanoparticles. X-ray diffraction (XRD) analysis confirmed the crystalline nature of the nanoparticles that displayed the preferential orientation of the crystals toward the (111) plane.  Antimicrobial activity was assessed using the resazurin assay method.  A minimum inhibitory concentration (MIC) of less than 7.8 µg was observed in Staphylococcus aureus and Klebsiella pneumoniae. In the antifungal activity, MIC at 250 µg was noted in Mucor sp. and Candida albicans. Antidiabetic activity was assessed by α-amylase and α-glucosidase inhibitory assay. IC50 of α-amylase and α-glucosidase activity of the silver nanoparticles was noted as 218 and 221 µg/mL, respectively. IC 50 value for the enzymatic assay dose-dependently confirmed the effect. Conclusively biosynthesized nanoparticles from vermiwash showed potential efficiency of antibacterial, antifungal and antidiabetic activities.
Manufacturing and assessing new samplers to measure wind soil erosion
Authors: Meselhy Adil Abdelsamia , Wassif Omnia Mohamed
Published: December 2021

Wind soil erosion is one of the most important causes of soil degradation that impede the process of sustainable agricultural development. The first step to mitigating wind erosion hazards is to find an effective and accurate way to assess its severity. Therefore, the main objective of this research was to raise and evaluate the efficiency of the new four traps to measure eroded soil, Fixed Distance trap (FD), Fixed Point trap (FP), Rotary Distance trap (RD) and Rotary Point trap (RP). The study traps RP and FP compared with the Big Spring Number Eight trap (BSNE) (traditional trap) and the traps RD and FD compared with the Bagnold trap (traditional trap). The results indicated that the order of study traps in terms of soil collection efficiency and soil retention efficiency were RD>FD>Bagnold>RP>FP>BSNE and FP>RP>RD>FD>Bagnold>BSNE, respectively. Results proved that the best traps in collecting eroded soil were RP trap followed by FP trap, compared to BSNE trap. Also, the best traps in collecting eroded soil were RD trap, followed by FD trap, compared to the Bagnold trap. The most important results showed that the relative efficiency of RP and FP traps were 181% and 159%, respectively, compared to BSNE and the relative efficiency of RD and FD traps were 186% and 172%, respectively, compared to the Bagnold trap. The study proved high accuracy of new traps in measuring soil eroded material, separating soil particles according to their size directly inside traps and determining the direction of the wind compared to traditional traps.
Desiccation-resurrection linked antioxidant machinery of a moss species Campylopus flexuosus (Hedw.) Bird.
Authors: S. S. Usha , Krishnan Remya , K. Murugan
Published: December 2021

Dehydration and rejuvenation during rehydration is the salient feature of certain plants which can withstand drought. The present study was undertaken to justify the tolerance capacity of Campylopus flexuosus, the moss of the Ponmudi belts of Thiruvananthapuram, against dehydration followed by rehydration. Fresh leafy plants of C. flexuosus were hydrated, afterwards dried, and rehydrated under in vitro environment. In the course of loss of water from cells, the relative water content of desiccated thallus was reduced after 4 h with intense inward curling. Upon rehydration, the RWC was regained 85% of its initial water content within hours. The rehydrated thallus showed the normal morphology. Photosynthetic parameters like chlorophyll b (1.01 to 1.56 μg g –1 ), and total carotenoid (0.251 to 0.514 μg g –1 ) increased remarkably in the desiccated state. Superoxide radical (O2 _) content increased (11.4 nmol/g FW), resulting in an oxidative burst during desiccation. Consequently, antioxidant enzymes such as catalase (0.369 U mg protein −1), superoxide dismutase ( 2.68 to 6.02 Units mg−1), peroxidase ( 0.12 μmol min−1 g−1 protein) and glutathione reductase ( 312 Units mg−1 protein) activities were up-regulated in the desiccated thallus to ameliorate oxidative damage. Increased malondialdehyde (1.08 nmol g−1 FW) content during desiccation substantiates membrane damage and loss of its integrity. During desiccation, the osmolytes sucrose and proline (27.6 and 2.57 μmol/g FW respectively) were enhanced to maintain cell structure integrity. After rehydration, biochemical and morphological properties were maintained similar to hydrated conditions. Thus, the study reflects the unique adaptations of the moss to tide over desiccation tolerance.
Extrapolation of post-harvest soil test values in barnyard millet-based cropping sequence through multivariate analysis
Authors: Selvam R. , Santhi R. , Maragatham S. , Chandrasekhar C.N. , Ganapathi Patil Santosh
Published: December 2021

The soil test value is based on the soil test-based fertilizer prescription/ recommendation equation. Each crop harvesting after the next crop is necessary to analyze the soil. Therefore, it is necessary to develop an alternative technique to predict postharvest soil tests after the harvest of every crop. For that a study was conducted in mixed black calcareous soils at Tamil Nadu agricultural University, Coimbatore to develop the post-harvest prediction equations for available nitrogen, phosphorus and potassium in barnyard millet cropping sequence based on a multiple regression model by considering post-harvest soil test value as the dependent variable and initial available nutrients, fertilizer doses and crop yield or crop nutrient uptake as an independent variables. The developed model was validated by computing R2 value, RMSE (root means square error), RE (relative error), and the ratio of performance to deviation (RPD) and the developed model was found to be valid.  Using the validated model, post-harvest soil test values were predicted. A fertilizer recommendation was made for blackgram based on predicted post-harvest soil test values in the barnyard millet-blackgram cropping sequence. The predicted soil test values were compared with actual soil test values and it revealed that the developed model is fairly accurate and best-fitted with more precision. The predicted post-harvest soil test values of barnyard millet could be used in order to prescribe fertilizer for desired yield targets for subsequent crops.
Seasonal incidence and efficacy of botanical insecticides against Painted bug, Bagrada hilaris (Burmeister) (Hemiptera: Pentatomidae) in Indian mustard (Brassica juncea genotype RH 725)
Authors: Kumar Hemant , Singh Sumer , Yadav Amit , Kumar Mahesh
Published: December 2021

Bagrada hilaris (Burmeister) is a serious pest of Brassica crops in the North-Western region of India, inflicting crop yield losses. Therefore, the present study was conducted on seasonal incidence and management of B. hilaris in Brassica juncea genotype RH 725 at farmer’s field, Kolana village, Aravalli Hills Region, Rewari, Haryana, India during Rabi, 2019-20 and 2020-21. This study laid out the trial in a randomized block design with three replications and six treatments viz., Neem Seed Kernel Extract (NSKE) @ 7%, Nimbecidine @ 0.03%, Neem oil @ 5%, NSKE @ 5%, Neem oil @ 7% and control (unsprayed). Observations on the incidence of B. hilaris showed that it appeared from 5th Standard Meteorological Week (SMW) (0.34 bugs plant-1) and attained peak during 10th SMW with 5.77 bugs plant-1. The incidence of B. hilaris exhibited significant positive correlation with maximum (r=0.852, p<0.05) and minimum (r=0.900, p<0.05) temperature, rainfall (r=0.763, p<0.05) and wind velocity (r=0.959, p<0.05). Spray of Neem oil @ 7% (83.01 %) was the most effective in reducing the B. hilaris population over control followed by NSKE @ 7% (81.48 %), while NSKE @ 5% (68.85 %) confirmed least effective. Seed yield in different treatments varied from 1440.5 kg ha-1 (NSKE @ 5%) to 1590 kg ha-1 (Neem oil @ 7%) against 1216 kg ha-1 in control. The highest incremental cost-benefit ratio was registered with NSKE @ 7% (1: 7.70) followed by Nimbecidine @ 0.03% (1: 7.41) and NSKE @ 5% (1: 6.25). The present investigation signified that the study on the seasonal incidence of B. hilaris in relation to weather parameters could provide information for planning pest control and management strategies. The botanicals could be used as eco-friendly and economical substitutes for chemical insecticides at farmer’s fields against this insect pest.
Chemomicrobiome analysis of the ornithine molecule
Authors: Torshin I. Yu. , Gromova O. A. , Maksimov V. A.
Published: December 2021

Hepatoprotectors and prebiotic molecules that promote the growth of intestinal flora differ significantly in their effects on different representatives of the human microbiome. This work presents the results of a comparative chemomicrobiomic analysis of ornithine and reference molecules (S-ademetionine, ursodeoxycholic acid, lactulose, and fructose). For each of the studied molecules, estimates of the values of the area under the growth curve were obtained for a representative sample of human microbiota, which included 38 commensal bacteria (including bifidobacteria and lactobacilli) and the values of the minimum inhibitory concentrations (MIC) for 152 strains of pathogenic bacteria. It has been shown that ornithine, to a lesser extent than the reference molecules, stimulates the growth of pathogenic bacteria of the generaAspergillus, Klebsiella, Pseudomonas, StaphylococcusandCandida fungi. Ornithine is also less likely to stimulate the growth of more aggressive bacteria (Biosafety Level 2) and to a greater extent less aggressive bacteria (Biosafety Level 1). By stimulating butyric and other short-chain fatty acid-producing microorganisms, ornithine can improve the profile of gut microbiota.
Expression of the Sod1 gene under conditions of experimental ethanol intoxication and administration of hepatoprotective drugs
Authors: Mukhammadieva G. F. , Bakirov A. B. , Karimov D. O. , Valova Ya. V. , Ziatdinova M. M. , Kudoyarov E. R. , Repina E. F. , Yakupova T. G.
Published: December 2021

The aim of the study was to study the effect of hepatoprotective drugs on the expression of the Sod1 gene in rats with ethanol liver damage.

Materials and methods. Male outbred white rats were used in the experiment. Five groups of animals were formed, 14 individuals each. Distilled water was administered to rats of the 1st group (control); Group 2 — ethanol at a dose of 5 g/kg of body weight; Group 3 — ethanol and heptor at a dose of 72 mg/kg; Group 4 — ethanol and mexidol at a dose of 50 mg/kg; Group 5 — ethanol and OMU at a dose of 50 mg/kg. The drugs were administered 1 hour before the introduction of ethanol. 24 and 72 hours after the introduction of ethanol (7 individuals), the animals were decapitated and the liver was removed. The expression level of the Sod1 gene was assessed using real-time reverse transcription PCR.

Results. The fold change in Sod1 expression in rat liver after 24 h practically did not change in response to the introduction of ethanol to the animals. A tendency to a slight decrease was observed in relation to changes in the expression of Sod1 with the use of heptor and mexidol, while under the influence of OMU, the expression level increased moderately. After 72 h, the exposure to ethanol was accompanied by a slight decrease in the frequency of expression of the Sod1 gene. A similar trend was observed with respect to changes in Sod1 expression with the use of heptor, mexidol, and OMU.

Conclusion. The results obtained indicate that the introduction of both ethanol and the prophylactic use of hepatoprotective drugs did not lead to significant changes in the level of Sod1 gene expression in rat liver. Additional studies are needed to identify the mechanisms of regulation of the antioxidant system, as well as the search for drugs that affect the transcriptional activity of genes.
Inflammatory bowel disease and drug-induced liver damage
Authors: Volynets G. V. , Khavkin A. I.
Published: December 2021

The article presents the results of a review of publications devoted to the study of the problems of drug-induced liver damage in inflammatory bowel diseases (IBD). The hepatotoxic effect of thiopurines (azathioprine and 6-mercaptopurine) — hepatotoxicity from 0% to 17%; sulfasalazine and mesalamine (hepatotoxicity from 0% to 4%); methotrexate (hepatotoxicity from 15% to 50%); tumor necrosis factor inhibitors (hepatotoxicity up to 75% of cases.), anti-integrins (hepatotoxicity from 2% to 5%); an interleukin 12/23 inhibitor (hepatotoxicity from 0,5% to 2%); Janus-kinase inhibitors is considered (hepatotoxicity from 1% to 2%).

Conclusion. The drugs currently used to treat IBD require periodic liver function tests to rule out drug-induced lesions that require therapy correction. As the range of new drugs is rapidly expanding, this requires special observation and discussion in terms of their adverse effects on the liver.
Gaucher's disease
Authors: Saifutdinov R. G. , Akhunova R. R. , Kurshakov A. A. , Mitusheva E. I. , Saifutdinov R. R. , Volgina S. Ya.
Published: December 2021

The article presents a rare clinical case of Gaucher's disease, a hereditary disease that belongs to lysosomal accumulation diseases. A 36-year-old patient was admitted to the clinic with complaints of pain in the left half of the abdomen, pain in the chest, cough with yellow sputum, difficulty breathing due to pain, general weakness. The mental underdevelopment, hepatosplenomegaly, anemia, thrombocytopenia, and the threat of rupture of the spleen were revealed in the process of collecting anamnesis and examination. The patient was transferred to the surgical department, and a splenectomy was performed. Histological examination of the spleen and genetic examination confirmed the diagnosis of Gaucher's disease.
Hyperenzymemia after vaccination against COVID-19: complex equation with simple variables
Authors: Ilchenko L. Yu. , Fedorov I. G. , Totolyan G. G. , Karelina A. M. , Sedova G. A. , Finkelberg G. E. , Termosesova E. Yu. , Nikitin I. G.
Published: December 2021

The article presents clinical case of the jaundice development and severe hyperenzymemia in GAM-Covid-VAK (Sputnik V) vaccination against COVID-19 in a 69-year-old patient. History — systematic use of non-steroidal anti-inflammatory drugs due to persisting pain after knee arthroplasty in 2018; frequent trips for several years to another region for sanatorium treatment, the use of mineral water. The diseases caused by hepatitis viruses, drug damage and post-vaccination reaction were included in diagnostic search. The markers of hepatitis B and C infection viruses were not detected during the enzyme immunoassay and polymerase chain reaction. The indicator for determining the relationship of a drug with the liver damage development was 6 points (borderline value) and only indicated the likelihood of drug hepatotoxicity. At the same time, it is known from history that repeated administration of the drug did not cause liver dysfunctions. The diagnosis of coronavirus infection was established based on the identification of SARS-CoV-2 in the hospital with repeated laboratory testing and competing diagnosis of hepatitis A has been confirmed on the basis of hepatocellular damage and the presence of serological marker of hepatitis A virus (immunoglobulin M antibodies). The treatment was continued in the infectious hospital, where the diagnosis of co-infection was confirmed. The pneumofibrotic changes in the S5 region of the left lung were revealed according to computed tomography. The normalization of aminotransferase activity and bilirubin was noted during dynamic observation. Apparently HAV infection led to a decrease in the immune response, the formation of an insufficient level of neutralizing antibodies in vaccinated against COVID-19 patient M. and contributed to the development of a new coronavirus infection with minimal manifestations in contact with SARS-CoV-2.
Comorbidity of NAFLD and GERD as a cardiometabolic phenomenon
Authors: Khlynova O. V. , Liu K. M.
Published: December 2021

The aim of the study was to study the cardiometabolic characteristics in individuals with an associated course of non-alcoholic fatty liver disease (NAFLD) and gastroesophageal reflux disease (GERD) in comparison with isolated cases of diseases.

Materials and methods. The study included 120 patients (30 — with GERD, 30 — with NAFLD, 30 — with GERD + NAFLD. Work design — prospective parallel comparative study with 2 stages. Stage I — inclusion in the study, assessment of the main cardiometabolic, cardio vascular rice (CVR) according to the SCORE scale and the Framingham scale. Stage II — follow-up of the participants for 5 years, re-examination and riskmetry.

Results. It has been shown that with a combination of NAFLD and GERD, the pathogenetic mechanisms involved in the formation of NAFLD (especially in steatohepatitis) affect the key characteristics of the metabolic profile and the state of the CV system to a greater extent than GERD. The total CVR values in this category of patients were: 4.8 — SCORE; 13.4 — on the Framingham scale. Over 5 years in this group, 10 (33% of the initial) newly diagnosed cases of CVD were verified: 6 — AH, 3 — IHD, 1 — AH + IHD. CVR for the NAFLD and GERD group increased: according to the SCORE scale — from low risk (4.8) to high (8.9), and according to the Framingham scale, the dynamics was even more negative (from 13.4 to 18.6).

Conclusion. Kinds of cardiometabolic disorders in persons with comorbidity of NAFLD and GERD have been proven, which can form the prerequisites for structural cardiovascular changes, including the risks of CVD. This can be a rationale for carrying out additional preventive measures for the groups of patients under discussion, especially in the case of their associated course, as measures for the early preclinical diagnosis of CVR factors and for timely correction of the identified disorders.
NAFLD Associated Comorbidity
Authors: Lazebnik L. B. , Turkina S. V.
Published: December 2021

Non-alcoholic fatty liver disease (NAFLD) is considered not only as a disease with poor hepatic prognosis. The problem has acquired a multidisciplinary problem. The variety of concomitant diseases and pathological conditions are united by common pathophysiological mechanisms.

This review summarizes and presents the data available in the modern literature on the association of NAFLD with cardiovascular diseases, type 2 diabetes mellitus, polycystic ovary syndrome, chronic kidney disease, etc. The role of the liver in the homeostasis of the organism and the pathogenetic mechanisms of the formation of NAFLD-associated comorbidity are discussed.
Diagnosis of liver fibrosis: an emphasis on elastography
Authors: Zhirkov I. I. , Gordienko A. V. , Pavlovich I. M. , Chumak B. A. , Yakovlev V. V.
Published: December 2021

In the strategy of managing patients with chronic diffuse liver diseases, the priority areas are the determination of the diagnosis with the determination of the main risk factors, the activity of the process (steatosis, steatohepatitis), as well as the degree of fibrous transformation. The rate of progression of liver fibrosis is a decisive factor that will determine the prognosis, treatment tactics and the likelihood of severe complications. The “gold standard” for diagnosing chronic liver pathology is a puncture liver biopsy with morphological examination of the liver tissue. At the same time, potential complications, contraindications to the procedure, low patient compliance, as well as errors in the interpretation of the results obtained due to various reasons are significant limitations of this diagnostic method. These shortcomings were the reason for the search for reliable non-invasive methods for diagnosing liver fibrosis both during the initial examination and during subsequent monitoring in dynamics. Modern methods of liver elastography are widely used for non-invasive assessment of fibrosis, demonstrating good diagnostic capabilities and significantly reducing the need for liver biopsy. Various elastography methods, which have their own advantages and disadvantages, effectively complement each other, which is successfully used in clinical practice in the diagnosis of fibrous transformation. The combined use of elastographic methods and commercial predictive diagnostic panels will increase the diagnostic accuracy in the determination of liver fibrosis.
Gender assessment of the gut microbiome in obese patients
Authors: Kotrova A. D. , Shishkin A. N. , Voropaeva L. S. , Lavrenova N. S. , Slepyh L. A. , Lukashenko M. V. , Ermolenko E. I.
Published: December 2021

The aim. To assess the relationship between body mass index (BMI) and gut bacteria in men and women with obesity.

Materials and methods. The study included 56 overweight patients, divided into 2 groups. The first group consisted of 27 women (the average age was 62 ± 2.2 years), the second group — 29 men (the average age was 55 ± 9 years). The Quetelet index (kg / m2) was calculated for all patients. To study the gut microbiome, the method of polymerase chain reaction in real time (RT-PCR) and metagenomic sequencing were used. DNA from feces was isolated using the Express-DNA-Bio DNA isolation kit (AlkorBio, Russia). To carry out RT-PCR, a set of reagents “Colonoflor-16” (“Alfalab”, Russia) was used. For microbiome sequencing, DNA libraries were prepared using the Illumina Nextera Sample Preparation Kit with DNA primers corresponding to the V3 — V4 regions of the 16S rRNA gene. The study of fecal samples was carried out using 16S rRNA gene sequencing on the Illumina platform (MiSeq sequencer).

Results. It was revealed that a higher total number of bacteria, an increased content of Bacteroides fragilis group and Faeca-libacterium prausnitzii, is statistically significantly more common in women than in men. Strong negative correlations were found between BMI and total bacterial mass, between BMI and the number of Bacteroides fragilis group among women with grade I obesity. In overweight men, a correlation was found between BMI and the Bacteroides fragilis group / Faecalibacterium prausnitzii ratio.

Conclusions. The total number of bacteria, the content of Bacteroides fragilis group and Faecalibacterium prausnitzii in the gut of patients have statistically significant associations with BMI, and probably can affect the formation of metabolic disorders to a greater extent in women than in men. To clarify the identified trends and patterns in this pilot study, further study of the microbiome with a large number of patients and additional analyzes of the metagenome (16S rRNA) and metabolome, a transcriptome, allowing to control the expression of key metabolic enzymes, largely associated with the compositional features of the gut microbiocenosis, is required.
CURRENT DIAGNOSING OF ASTHMA IN CHILDREN
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Rechkina O. O.
Published: December 2021

O. O. Rechkina Abstract Underdiagnosis and late diagnosis of asthma in children remain the topical problem of current world and local pediatrics, especially in primary medical care. Considering recent literature data, the author has presented the latest recommendations on timely diagnosis of asthma in children. The causes of underdiagnosis of the disease, terminology difficulties, risk of asthma progression development have been reviewed. Based on 2021 European Respiratory Society recommendations the key criteria of asthma diagnosis in children of different age have been listed. Key words: asthma in children, risk criteria, diagnosis
CYTOPROTECTIVE THERAPY FOR PATIENTS WITH RESPIRATORY PATHOLOGY: PROPERTIES OF EKTOIN
Authors: Zaikov S. V. , Bogomolov A. E. , Mikhei L. V.
Published: December 2021

CYTOPROTECTIVE THERAPY FOR PATIENTS WITH RESPIRATORY PATHOLOGY: PROPERTIES OF EKTOIN S. V. Zaikov, A. E. Bogomolov, L. V. Mikhei Abstract In light of the often irrational use of antibiotics, the growing problem of antibiotic resistance of respiratory pathogens and certain imperfections in the management of patients with acute and chronic rhinosinusitis, acute and chronic bronchitis, exacerbations of chronic obstructive pulmonary disease, there is always a need to seek for a new (non-antibacterial) methods of treatment to increase the effectiveness of therapy in these categories of patients. Probably, cytoprotection may also become one of these methods. Aim — to analyze the results of ectoine use as a respiratory cytoprotector. Material and methods. Analysis of available scientific publications on the use of ectoine in medical practice has been done. Conclusions. Ectoin is a natural molecule of extremolyte that strengthens the bonds and the number of neighboring water molecules, organizes water from a chaotic fluid into a structured Ectoin® Hydro Complex, which surrounds mucous cells with a protective layer of water and leads to barrier protection of the mucous membrane. The natural molecule of ectoine has anti-inflammatory, membrane-stabilizing and cytoprotective properties. Ectoin is used for barrier protection and recovery of the mucous membrane of the respiratory tract in acute and chronic diseases of the upper and lower respiratory tract. Efficacy and safety of ectoine, including its long-term use, werev proved by the results of preclinical and clinical studies. Key words: cytoprotective therapy, ectoine, respiratory pathology
POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT
Authors:   SO “National institute of phthisiology and pulmonology named after F. G. Yanovsky NAMS of Ukraine”, Rechkina O. О. , Strafun O. V. , Polianska М. О. , Budyonna М. Р.
Published: December 2021

POSSIBILITIES OF NONTRADITIONAL MEDICINE IN ADDITIONAL TREATMENT FOR INFLAMMATORY DISEASES OF THE RESPIRATORY TRACT O. О. Rechkina, O. V. Strafun, М. О. Polianska, М. Р. Budyonna Abstract Oxidative stress plays an important role іn the pathogenesis of airway inflammatory diseases. Multivitamin preparations containing antioxidants, nutritional supplements are significant support in the fight against oxidative stress. The healing properties of one such supplement, badger fat, have been known for centuries. It is used in folk medicine as a natural and effective agent with bactericidal, anti-inflammatory, immunostimulating and general strengthening effects. The main active components of badger fat include unsaturated fatty acids and vitamins, especially A, E and D. Vitamins of these groups enhance the anti-inflammatory effect of unsaturated fatty acids, and also exhibit high antioxidant activity, while unsaturated fatty acids (including omega-3, omega-6), help to improve metabolic processes and tissue trophism, exhibiting anti-inflammatory and antioxidant effects. The article presents the characteristics of the dietary supplement “Borsukovy zhyr”, the results of studies of its effectiveness and tolerability in the complex treatment of chronic bronchitis and AE COPD, as a component of therapy of adults and children with bronchopulmonary diseases, showing its effectiveness, safety and good tolerability. The supplement can be used in the complex treatment of bronchopulmonary pathology in both adults and children as a safe source of fat-soluble vitamins and polyunsaturated fatty acids. Key words: oxidative stress, antioxidants, dietary supplement, badger fat.
HUKUM ADAT LONTARA
Authors: Arief Muhammad
Published: December 2021

Aksara Lontara adalah aksara tradisional masyarakat Sulawesi Selatan yang umumnya digunakan oleh suku Bugis, Makassar, dan Mandar. Aksara kuno ini kemudian terus berevolusi seiring perkembangan zaman, hingga akhirnya menjadi Aksara Lontara yang dikenal saat ini. Bentuk aksara ini memiliki nilai budaya yang sangat mendalam bagi masyarakat suku Bugis-Makassar, yaitu bentuknya yang berasal dari filosofi “Sulapa Eppa” yang berarti Empat Sisi api, air, tanah, dan angin, susunan semesta kepercayaan mistis Suku Bugis klasik. Penggunaan aksara ini digunakan oleh suku Bugis yang secara geografis tersebar di hampir seluruh penjuru Sulawesi Selatan.
Article-Febriyanto
Authors: lydia
Published: December 2021

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh kualitas jasa dan kualitas pelayanan yang terdiri dari variabel reliablility, responsiveness, assurance, empathy, dan tangible terhadap kepuasan pelanggan terhadap toko buku Gramedia. Populasi dalam penelitian ini adalah pelanggan yang mengunjungi toko buku Gramedia. Jumlah sampel yang didapatkan menggunakan sebuah kuesioner adalah 30 Responden dengan menggunakan metode Simple Random Sampling. Selain metode Simple Random Sampling, yaitu metode Servqual. Di mana metode Servqual dimulai dengan menghitung gap atau selisih antara harapan pelanggan mengenai layanan jasa dengan kenyataan pelayanan yang dirasakan pelanggan. Dari hasil penelitian menunjukkan bahwa kualitas jasa dan kualitas pelayanan dapat berpengaruh positif dan signifikan terhadap kepuasan pelanggan kepada toko buku Gramedia.
ANALISIS LAPORAN KEUANGAN
Authors: Aulya Winda
Published: December 2021

Analisis laporan keuangan adalah sebuah proses mengamati performa perusahaan dalam konteks lingkungan industri dan ekonomi dengan tujuan pengambilan keputusan tertentu. Biasanya, keputusan yang akan dibuat berkaitan dengan penyediaan modal bagi perusahaan, terutama investor yang ingin menanamkan modal atau lembaga pemberi pinjaman.
UAS
Authors: Nderu Nirmayati Fatima
Published: December 2021

Instagram sekarang menjadi salah satu media populer di kalangan masyarakat saat ini.Instagram menjadi salah satu media bagi banyak orang dalam menyalurkan kreatifitasnya. Tujuan penelitian ini adalah menjelaskan bahwa pengguna Instagram dengan followers terbanyak dari para artis Indonesia.
Struktur Aljabar Grup
Authors: jannah Raudati
Published: December 2021

Pembuktian memainkan peranan penting dalam struktur aljabar karena dengan definisi, lema dan teorema. Kemampuan pembuktian yang dimaksud disini adalah kemampuan mahasiswa memvalidasi atau mengkritisi bukti dan mengkontruksi bukti yang berhubungan dengan jenis-jenis pembuktian yang sering muncul dalam mata kuliah struktur aljabar grup, khususnya dalam topik teori grup. Dalam kenyataannya, masih banyak mahasiswa yang mengalami kesulitan dalam melakukan proses pembuktian
Studi Kasus Asuhan Keperawatan Psikososial Dengan Masalah Ansietas Pada Penderita Diabetes Mellitus
Authors: Manurung Salinda
Published: December 2021

. Ansietas (Kecemasan) yang bisa berlanjut pada status kesehatan jiwa akibat dari rasa takut dan khawatir mengenai terjadinya sesuatu hal yang akan menimpa kehidupan serta bisa berlanjut secara terus menerus dalam diri individu tersebut
Laporan SKB Es Cincau Pargoy
Authors: Sugiatni Evi , nurfitri  , Saputri Anggraeni Dwi , Rasyid A. Syahrul Ramadhan , khaerunnisa  , widiyanti  , Islami Adelia Nurul , Ananda Ahriana
Published: December 2021

Sebagian besar orang tidak tau bahwa cincau merupakan bahan yang mudah didapatkan, selain harganya yang murah, cincau juga tersedia dimana- mana dan sekarang sudah ada produk bubuk cincau yang dapat kita buat sendiri di rumah. Akan tetapi olahan cincau selama ini masih sebatas es cincau biasa karena itu kami mengembangkan olahan cincau ini menjadi sebuah komoditi yang menguntungkan.Cincau adalah minuman yang diantara isinya ada semacam agar-agar yang dibuat dari daun cincau. Agar-agar cincau serupa dengan gel yang diperoleh dari perendaman daun tumbuhan tertentu dalam air. Gel terbentuk karena daun tumbuhan tersebut mengandung karbohidrat yang mampu mengikat molekul- molekul air.Daun cincau hijau juga mengandung flavonoid. Senyawa flavonoid mempunyai ikatan gula yang disebut aglikon yang berikatan dengan berbagai gula dan sangat muda terhirolisis atau mudah lepas dari gugus gulanya. Flavonoid merupakan antioksidan yang berpotensi mencegah radikal bebas. Senyawa tersebut mempunyai sifat anti bakteri dan anti viral kegunaan daun cincau hijau.
Aturan Penetapan Do' i Menrek Dalam Perkawinan Masyarakat Adat Suku Bugis (Analisis Teori Urf Dan Appanngadereng Dalam Hukum Adat Suku Bugis)
Authors: Haedir Muhammad
Published: December 2021

Dalam tradisi perkawinan suku Bugis , mahar yang merupakan salah satu ketentuan dalam hukum perkawinan Islam, dalam masyarakat suku Bugis disebut sompa. Sompa ini sepenuhnya menjadi hak-milik pengantin wanita sebagai wujud penghormatan pengantin pria kepada pengantin wanita. Meskipun ketentuan do’i menrek-balanca hanya berdasarkan tradisi masyarakat Suku Bugis tetapi kedudukannya sama dengan mahar (sompa) yaitu sama-sama mengikat.
Entropic Information Theory: Formulae and Quantum Gravity, Bits from Bit
Authors: denis olivier
Published: December 2021

We show here that entropic information is capable of unifying all aspects of the universe at all scales in a coherent and global theoretical mathematical framework materialized by entropic information framework, theory and formulas, where dark matter, dark energy and gravity are truly informationals processes and where information is code and code is what creates the process, it is itself the process. Mass, energy and movement of information are respectively dark matter, dark energy, and gravity. Here, we reconcile general relativity and quantum mechanics by introducing quantum gravity for the Planckian scale. The formulas of entropic information are expressed in natural units, physical units of measurement based only on universal constants, constants, which refer to the basic structure of the laws of physics: C and G are part of the structure of space-time in general relativity, and h captures the relationship between energy and frequency that is the basis of quantum mechanics. Here we show that entropic information formulas are able to present entropic information in various unifying aspects and introduce gravity at the Planck scale. We prove that Entropic information theory is thus building the bridge between general relativity and quantum mechanics
fungsi peranan bank syariah dan lembaga keuangan non bank
Authors: susanti Erna
Published: December 2021

Lembaga keuangan bank dan non bank memiliki peranan penting dalam sistem keuangan suatu negara. Salah satunya adalah menjaga stabilitas keuangan dalam perekonomian suatu negara. Karena itu lembaga keuangan bank dan non bank menjadi salah satu pilar stabilitas ekonomi keuangan. Pertumbuhan dan perkembangan ekonomi syariah di Indonesia, secara otomatis ikut memacu perkembangan lembaga keuangan syariah baik bank maupun non bank. Oleh karena itu banyak inovasi-inovasi dari lembaga keuangan baik bank maupun non bank. Baitul ma>l wa tamwil dan koperasi syariah sebagai lembaga keuangan mikro berperan sangat penting dalam perkembangan ekonomi masyarakat. Karena lembaga-lembaga tersebut langsung bersentuhan dengan industri mikro yang dijalankan oleh masyarakat luas.
ANALISIS LAPORAN KEUANGAN
Authors: Rafli Muh.
Published: December 2021

Analisis laporan keuangan merupakan suatu proses yang digunakan untuk mengkaji, mengukur, dan memahami hal-hal yang tertulis dalam laporan keuangan suatu perusahaan. Dari analisis ini, dapat diketahui kondisi dan keuangan perusahaan.
Madduta Dan Mappacci Dalam Perkawinan Adat Masyarakat Bugis Lontara
Authors: Haq Wulan Arie Chantika
Published: December 2021

Madduta dikenal dengan istilah Mammanumanu yaitu pihak keluarga laki-laki atau calon mempelai laki-laki melihat-lihat atau memantau dan mencari informasi tentang asal- usul perempuan yang akan dilamar atau dipinang.Madduta adalah pengiriman utusan untuk mengajukan lamaran dari seorang laki-laki kepada seorang perempuan yang telah disepakati oleh pihak keluarga laki-laki.
PEMBELAJARAN DASAR ALGORITMA PEMROGRAMAN
Authors: Ardhiansyah Farhan
Published: December 2021

Algoritma adalah metode efektif yang diekspresikan sebagai rangkaian terbatas. Algoritma juga merupakan kumpulan perintah untuk menyelesaikan suatu masalah. Dengan algoritma terdapat urutan langkah dalam menyelesaikan sebuah masalah. Langkah - langkah tersebut disusun secara sistematis. Algoritma adalah suatu prosedur dalam pemecahan masalah yang mengurutkan langkah – langkah integrasi dengan menggunakan metode khusus (Kamus Webster) untuk memecahkan suatu masalah nyata.Pembelajaran bertujuan untuk memperoleh pengalaman dalam hal pengetahuan, keterampilan dan nilai guna meningkatkan kuantitas dan kualitas.Untuk itu, pendidikan harus mampu menumbuhkan bakat - bakat kreatif. Masalah pembelajaran membutuhkan pemikiran kreatif, terutama ketika belajar memprogram, dan kemampuan berpikir secara algoritmik agar program dapat tampil seperti yang diharapkan.
E-Business Adaptation GSLC TUT 4 (Deka Taufiq Riansyah - 2301957313)
Authors: Dekataufiq.R
Published: December 2021

Pada tahun 2021, E-commerce mengalami peningkatan rata rata yang terus bertambahtiap tahunnya. Saat di masa pandemic seperti sekarang E-Commerce terus meningkat,dikarenakan pandemic Covid 19 orang orang malas untuk berbelanja keluar rumah dan lebihmemilih untuk berbelanja melalui E-commerce karena lebih cepat dan efisien. Adapunbeberapa E-commerce yang sangat merajai pasar di Indonesia, diantaranya adalah Shopee,Tokopedia, Bukalapak, Lazada, Blibli dan lain-lain. Tujuan dari Paper ini dibuat adalah untukmengetahui lebih mendalam mengenai adopsi E-Commerce dalam skala Indonesia ataupunsecara global.
Makalah Ekonomi Mikro Syariah
Authors: rusdin Zahra amaliyah , k Kelvin , khairunnisa nur , anisa Nur
Published: December 2021

Pasar monopolistik adalah pasar homogen atau berarti pasar dimana produsen dan konsumen hanya saling memenuhi kebutuhan barang yang sama atau sejenis tetapi setiap produsen mempunyai ciri khas produk masing-masing,dalam pasar monopolistik tingkat persaingan bisa dibilang sangat tinggi karena setiap perusahaan mempunyai produk yang sama dan biasanya berupa barang primer atau kebutuhan sehari-hari,setiap pengusaha sangat mudah masuk dan keluar dalam pasar monopolistik karena banyaknya sumber daya alam dan peluang yang cukup lebar,setiap perusahaan berlombalomba menciptakan produk terbaik yang sekilas sama tapi tetap mempunyai perbedaan .
Imaging evolution of Cascadia slow-slip event using high-rate GPS
Authors: Itoh Yuji , Aoki Yosuke , Fukuda Junichi
Published: December 2021

The slip history of short-term slow slip event (SSE) is typically inferred from daily Global Positioning System (GPS) data, which, however, cannot image the sub-daily processes, leaving the underlying mechanisms of SSEs elusive. To address the temporal resolution issue, we attempted to employ the kinematic subdaily GPS analysis, which has never been applied to SSE studies because its signal-to-noise ratio has been believed too low. By carefully post-processing sub-daily positions to remove non-tectonic position fluctuation, our 30-minute kinematic data clearly exhibits the transient motion of a few mm during one Cascadia SSE. A spatiotemporal slip image by inverting the 30-minute data exhibits a multi-stage evolution; it consists of an isotropic growth of SSE followed by an along-strike migration and termination within the rheologically controlled down-dip width. This transition at the slip growth mode is similar to the rupture growth of regular earthquakes, implying the presence of common mechanical factors behind the two distinct slip phenomena. The comparison with a slip inversion of the daily GPS demonstrates the current performance and limitation of the subdaily data in the SSE detection and imaging.Better understanding of the non-tectonic noise in the kinematic GPS analysis will further improve the temporal resolution of SSE.
Einzug der EDV im österreichischen Bibliothekswesen am Beispiel der Universitätsbibliothek Graz
Authors: Lackner Karin , Schilhan Lisa
Published: December 2021

Durch den Einsatz von EDV-Systemen kam es ab den 1970er Jahren zu einem radikalen Wandel in der Benutzung und Verwaltung von Universitätsbibliotheken. Die Universitätsbibliothek Graz war die erste Bibliothek in Österreich, die ein elektronisches Bibliothekssystem entwickelte und einsetzte, womit sie zu den Vorreitern in Europa zählte. Dieser Artikel liefert einen historischen Überblick über die Anfänge, die Entwicklung und Verbreitung der elektronischen Bibliothekssysteme im Allgemeinen sowie an der Universitätsbibliothek Graz im Speziellen. Vorgestellt werden die im Lauf der Jahrzehnte an der UB Graz eingesetzten Bibliothekssysteme GRIBS, EMILE, FBInfo, BIBOS, ALEPH und ALMA sowie die Entwicklung von den ersten Online- über die CD-ROM-Datenbanken bis hin zum modernen Datenbank-Retrieval.
Elevated serum ferritin in non-alcoholic fatty liver disease is not predictive of fibrosis
Authors: Trasolini Roberto , Cox Ben , Galts Ciaran , Yoshida Eric M , Marquez Vladimir
Published: December 2021

BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is common with widely ranging severity. Non-invasive risk scores for risk stratification are recommended but misclassify a significant proportion of patients. In situations where non-invasive risk scores do not provide guidance, referral is typically made to a Hepatologist for transient elastography or liver biopsy. Serum ferritin is elevated in many patients with NAFLD related to dysmetabolic and inflammatory hyperferritinemia. Ferritin is widely available and part of a standard workup for chronic liver disease. METHODS: To explore the association of ferritin and risk of fibrosis in NAFLD, we reviewed patients diagnosed with NAFLD at the hepatology clinic of the Vancouver General Hospital between the years of 2015 and 2018. We collected data on 317 patients retrospectively assessing for a relationship between serum ferritin and elastography score. RESULTS: Two hundred twenty-four patients were included in the final analysis. Median ferritin was 145 µg/L (IQR 62–311). Median liver stiffness was 5.2 kPa with 14.3% of patients having liver stiffness ≥8.7 kPa and 17.4% ≥ 8.0 kPa. ROC curve analysis using a liver stiffness ≥8.0 kPa as a cutoff for F2 fibrosis showed an AUROC of 0.54 for serum ferritin levels. At a cut-off of both 300 µg/L; and 450 µg/L median liver stiffness did not differ significantly in those with ferritin above the cutoff (ferritin ≥300 µg/L; p = 0.099, ferritin ≥450 µg/L; p = 0.12). Ferritin was significantly higher in male patients (198 versus 91 µg/L; p = 0.0001). There was a weak linear association between AST and ferritin levels. CONCLUSION: In this cohort of 224 patients with NAFLD, serum ferritin was not predictive of significant liver fibrosis.
The Romance of Canada: Nationalism and Canadian Historiography
Authors: Litt Paul
Published: December 2021

This is a short overview history of the relationship between Canadian historians and Canadian nationalism. It maps the historiography of Canadian nationalism against its significant manifestations in Canadian society and developments in nationalism scholarship internationally. Three conjunctures when the fate of the nation loomed large in Canadian historiography are featured. Evidence from the Canadian Historical Review (chr) is highlighted throughout, and, for each conjuncture, relevant articles from the chr are provided for further reading. In reflecting on this history, this article considers Canadian historians’ accomplishments and failures in understanding Canadian nationalism as well as the contemporary politics and praxis of their relationship with nation.
TREE SPECIES SUSCEPTIBILITY TO LEAF-CUTTING ANTS ATTACK IN CARBON NEUTRALIZATION PLANTATIONS
Authors: Morais Júnior Vicente Toledo Machado de , Antônio Gonçalves Jacovine Laércio , Comine Frades da Silva Mateus , Schettini Bruno Leão Said , Rufino Maria Paula Miranda Xavier , Bifano Comini Indira , Henrique Villanova Paulo , José Silva Soares da Rocha Samuel
Published: December 2021

Greenhouse gas (GHG) emissions neutralize planting are one of the options for climate changes mitigating. Leaf-cutter ants attack is a threat to the plantations proper development. Ants have selective foraging, which makes it important to know this selectivity and, thus, choose more suitable species to neutralization planting compose. Thus, the goal of the present study was to evaluate the tree species susceptibility to be attacked by leaf-cutter ants in carbon neutralization plantations. The study was carried out in mixed plantations in Viçosa-MG and a classification was created for the present species. The Damage Index (DI) was created by multiplying the Mean of Severity (MS) and the Frequency of Attacks (FA). The species were classified according to the indication for neutralization plantations (indicated, moderately indicated, and not indicated) and potential species for the extraction of natural insecticides. From the 59 species evaluated, 22 were classified as suitable for neutralization plantations, 6 as moderately indicated, 24 as not indicated, and 7 as potential species for extracting natural insecticides.
Keywords: forest carbon; pest control; carbon offset; mixed plantings.
Estimation of the influence of hydraulic balancing of the heating system and shading of external enclosures on the energy consumption of the university building
Authors:   National University of Life and Environmental Sciences of Ukraine, Antypov I. , Mishchenko A. ,   National University of Life and Environmental sciences of Ukraine, Shelimanova E. ,   National University of Life and Environmental Sciences of Ukraine, Tarasenko S. ,   National University of Life and Environmental Sciences of Ukraine, Batechko N. ,   National University of Life and Environmental Sciences of Ukraine, Shostak S. ,   National University of Life and Environmental Sciences of Ukraine
Published: December 2021

The main design features of single-pipe systems with vertical wiring, the reasons for their low efficiency, which include: physical and moral obsolete equipment and pipeline valves, lack of automatic control and regulation of coolant supply, low efficiency of heating devices, are characterized. Using the methodology according to DSTU B V.2.6-189-2013 and DSTU B A.2.2-12: 2015, the effectiveness of the introduction of automatic balancing of the heating system was first investigated, and then the effect of shading of external enclosing structures on the energy consumption of the university building, taking into account the existing state of external enclosing structures ... It has been established that balancing the heating system makes it possible to reduce the specific energy consumption for heating by 7.6%, and to reduce the energy consumption of the heating system by 164.8 MWh. The influence of the shading of external enclosing structures on the energy consumption of the building of the university is estimated, taking into account the existing state of the external enclosing structures in the absence of balancing the heating system of the building. It is shown that it leads to an insignificant excess of energy consumption for heating by 0.3 % or 6.6 MWh. It has been proven that the energy consumption of a building, taking into account the shading coefficient after balancing the heating system, can reduce the specific energy consumption for heating by 7.9 %, and reduce the energy consumption of the heating system by 165.4 MWh. Assessing the effect of shading of external enclosing structures "before" and "after" balancing the heating system of the university building, it can be argued that the energy consumption of the heating system has been reduced by 158.8 MWh or by 7.7 %. Key words: flow, balancing, solar insolation, heating system, shading