bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation between swallowing function and cognitive function in community-dwelling elderly people
Authors:   Korean Aging-Frendly Ind Assoc, Jung Jung-Hwa , Lee Hye-Jin
Published: January 2025

Objective : The purpose of this study is to evaluate the prevalence and characteristics of dysphagia among community-dwelling older adults and to investigate the correlation between swallowing function and cognitive function.
Methods : The study was conducted over eight weeks, from June 1 to July 30, 2024, targeting 108 elderly individuals aged 65 years or older who attended A, B, C, and D Senior Welfare Centers located in W Metropolitan City. Descriptive statistics were derived from the collected data using SPSS 23.0 for Windows. Pearson correlation analysis was performed to examine the relationship between swallowing function and cognitive function in this population.
Results : Using the EAT-10 assessment, the prevalence and characteristics of dysphagia among community-dwelling elderly people were identified. The number of individuals reporting dysphagia-related difficulties was as follows: K1 (16), K2 (31), K3 (36), K4 (36), K5 (74), K6 (13), K7 (31), K8 (33), K9 (24), and K10 (25). Among the six cognitive function domains, the orientation (OR) domain showed a positive correlation with K5, while the domains of attention, visuospatial function, executive function, memory, and language showed negative correlations with the K-EAT-10 items.
Conclusion : The EAT-10 assessment confirmed a significant prevalence of dysphagia among community-dwelling elderly individuals. Many participants experienced issues such as weight loss, avoidance of eating out, and difficulty swallowing due to dysphagia. Analysis revealed that the severity of dysphagia was negatively correlated with various cognitive functions, including attention, visuospatial function, executive function, memory, and language.
КЛІНІЧНІ ЕТАПИ ЛІКУВАННЯ ТА ПАТОМОРФОЛОГІЧНА ХАРАКТЕРИСТИКА ЦЕРВІКАЛЬНОЇ ВНУТРІШНЬО-КОРЕНЕВОЇ РЕЗОРБЦІЇ З ПЕРФОРАЦІЄЮ СТІНКИ КОРОНКОВОЇ ЇЇ ЧАСТИНИ (КЛІНІЧНИЙ ВИПАДОК)
Authors: Добровольський Д.В. , Гевкалюк Н.О.
Published: January 2025

Мета дослідження. На основі вивчення клініко-морфологічних особливостей патологічної резорбції провести вибір адекватного методу лікування, що забезпечить виконання певних маніпуляцій за запропонованим алгоритмом і підвищить ефективність терапевтичних заходів. Методи дослідження. Проведено клініко-рентгенологічне дослідження пацієнта з цервікальною внутрішньо-кореневою резорбцією з перфорацією стінки коронкової її частини, гістологічне дослідження біоптату з ділянки резорбції зуба. Проведено поетапне лікування з використанням цементу на основі МТА (Mineral Trioksit Agregat) та послідуючим зміцненням зуба скло волоконним штифтом із використанням електронного мікроскопа (Karl Kaps, Німеччина). Наукова новизна. Розширено уяву про причини виникнення та клінічні прояви патологічної внутрішньо-кореневої резорбції зуба. Представлено патоморфологічну характеристику запального процесу в ділянці резорбтивних змін пульпи в коронковій та кореневій її частинах. Гістологічна картина біоптату відповідає тканинам пульпи, багатій на клітини з проявами запальної реакції, явищами набряку міжклітинної речовини та розволокненими на фібрили колагеновими волокнами міжклітинної речовини. Запропонований алгоритм і проведене поетапне лікування патологічної резорбції внутрішньої частини зуба з використання цементу на основі МТА та скло волоконного штифта продемонстрували успішний результат. Віддалені клінічні та рентгенологічні результати проведеного лікування підтвердили його ефективність. Висновки. На прикладі клінічного випадку з’ясовано клінічні та рентгенологічні аспекти внутрішньо-кореневої патологічної резорбції, розширено уяву про патоморфоз виявленої патології. Запропоноване лікування зуба з діагнозом цервікальна внутрішньо-коренева патологічна резорбція дало можливість досягнути успішного результату, що підтверджено клінічно, рентгенологічно та патоморфологічно.
Mineralogical features and physicochemical formation conditions of vein mineralization of the southern fank of the Saf'yanovka massive sulfde deposit (Central Urals)
Authors: Safna N.P. , Korovko A.V. , Blinov I.A. , Ankusheva N.N. , Rassomakhin M.A. , Filippova K.A.
Published: January 2025

The paper presents the results of studies of sulfde and fuorite veins of the southern fank of the Saf'yanovka massive sulfde deposit, Central Urals. The sulfde veins include sphalerite-galena and sphalerite-pyrite-chalcopyrite types, in which sulfdes are associated with gypsum, carbonates, barite or quartz. Fluorite in host rocks is closely related to carbonates (dolomite, calcite, and siderite), kaolinite and magnesiocarpholite. The sulfde veins differ in chemical composition and rare minerals. In galena-sphalerite veins, the higher Zn, Pb, Cd and Ag content is associated with the presence of sphalerite, galena and tennantite-(Zn) with Ag (up to 1.09 wt %). In sphalerite-pyrite-chalcopyrite veins, the accumulation of Cu, Sn, In, Se, Te and Bi is explained by the presence of tennantite-(Zn), enargite, stannoidite, sakuraiite (?), wittichenite, hessite and Se-bearing galena. The elevated (ppm) Th (1.69) и U (4.79) and REE + Y (447) content is determined in fuorite veins. The REE minerals include fuorcarbonates (synchisite-(Nd) (predominant), synchisite-(Y), synchisite-(Ce) and bastnasite), which are closely associated with overprinted dolomite and kaolinite. The fuid inclusions study of gypsum from pyrite-chalcopyrite veins showed that the associated Cu mineralization formed from H2O-Na-K chloride fuid at temperatures of 210–150 °С. The fuid, which was responsible for the formation of fuorite veins, contained Na, K, Ca и Mg. The formation temperatures of fuorite range from 190 to 280 °С. New data revealed the peculiarities of mineral composition of rich Cu ores with fuorite and also explain the higher content of some elements, including REEs.
Mineralogy and ore formation conditions of the Naily gold deposit (South Urals)
Authors: Smirnitskaya A.D. , Rozhkova E.A. , Belogub E.V. , Novoselov K.A. , Zabotina M.V. , Rassomakhin M.A.
Published: January 2025

The paper examines mineralogy of noble metals and ore formation conditions at the Naily gold deposit (South Urals), which is hosted in pyrite-bearing talc-carbonate, chlorite-quartz-carbonate and quartz-carbonate metasomatites after serpentinites and rocks of a gabbrodiorite-plagiogranite complex. Based on microscopic and electron microscopic studies of polished sections and heavy concentrates, it is established that native gold and Au tellurides are the major Au minerals of veins, metasomatites after intermediate and felsic intrusive rocks and foliated serpentinites. Native gold occurs as: 1) inclusions in pyrite and rarely in chalcopyrite, 2) free particles associated with non-metallic minerals, which probably fll interstitions, 3) interstitial forms in pyrite aggregates often together with chalcopyrite, galena and sphalerite, and veinlets in hessite, 4) fne inclusions in tetradymite and 5) inclusions in limonite. Tellurides of noble metals include calaverite, petzite, hessite and an unidentifed Ag and Pb sulfotelluride. Silver is also incorporated in acanthite and Hg-Ag-Sb-As, Pb-Bi-Ag and Cu-Ag-Pb-Bi sulfosalts. The Ag content of free native gold is 10–16 wt. % increasing to 20–24 wt. % in native gold in pyrite and in assemblage with hessite. Altaite, coloradoite and Ni and Pd tellurides are found in assemblages similar to noble metal mineralization. The formation temperature of chlorite from ore-bearing metasomatites is 339–392 °C. Fluid inclusions in quartz, calcite and albite are homogenized at a temperature range of 162–377 °C. The eutectic temperature (–23.5 °C) is typical of NaCl-KCl-H2O system. The ice melting temperature varies from –0.5 to –3.7 °C corresponding to salinity of 0.9– 6.0 wt. % NaCl-equiv.
ОРНИТОФАУНА ИЖЕВСКОГО ВОДОХРАНИЛИЩА
Authors: Меньшиков Александр Григорьевич , Князева Галина Юрьевна
Published: January 2025

Проведен анализ современного состояния орнитофауны Ижевского водохранилища и её динамика, по данным полевых исследований 2023-2024 гг. Дана количественная характеристика плотности населения птиц на различных биотопических участках территории в различные сезоны года, представлен аннотированный список птиц акватории и водоохраной зоны водохранилища.

The current state of the Izhevsk reservoir’s avifauna and its dynamics was analyzed. According to field studies, conducted in 2023-2024, we gives a quantitative characteristic of the density of the population of birds in various biotops of the territory in different seasons of the year. An annotated list of birds of the water area and the water protection zone of reservoir is presented.
ТЕНДЕНЦИЯ ИЗМЕНЕНИЯ АГРОКЛИМАТИЧЕСКИХ ПОКАЗАТЕЛЕЙ НА ТЕРРИТОРИИ ЧУВАШСКОЙ РЕСПУБЛИКИ В ПОСЛЕДНИЕ ДЕСЯТИЛЕТИЯ
Authors: Китарьева Марина Анатольевна
Published: January 2025

В данной статье рассматриваются изменения агроклиматических показателей на территории Чувашской Республики за период 1961-2023 гг. с использованием ежедневных данных метеорологических наблюдений 5-ти станций. Рассчитаны следующие характеристики: даты устойчивого перехода среднесуточной температуры воздуха через 5 и 10 °С весной и осенью, продолжительность периода вегетации и активной вегетации, суммы активных и эффективных температур, количество выпавших осадков за период активной вегетации, гидротермический коэффициент (ГТК) Селянинова, индекс сухости (ИС) Будыко, биологическая эффективность климата. Дана оценка биологической эффективности климата Чувашской Республики. Выполненные расчёты показали, что продолжительность вегетации увеличивается, в связи с этим увеличиваются суммы активных и эффективных температур. Выявлена тенденция слабого роста засушливости климата в республике за период исследования.

This article examines the changes in agro-climatic indicators on the territory of the Chuvash Republic for the period 1961-2023 using daily meteorological observations from 5 stations. The following characteristics were calculated: the dates of the steady transition of the average daily air temperature through 5 and 10 °C in spring and autumn, the duration of the growing season and active vegetation, the sum of active and effective temperatures, the amount of precipitation during the active growing season, Selyaninov hydrothermal coefficient (GTC), Budyko dryness index (IS), biological climate efficiency. Keywords: average daily air temperature, growing season, active vegetation period, sum of active temperatures, sum of effective temperatures, hydrothermal coefficient, dryness index. The assessment of the biological efficiency of the climate of the Chuvash Republic is given. The calculations performed showed that the duration of vegetation increases, and therefore the sums of active and effective temperatures increase. The trend of a weak increase in the aridity of the climate in the republic during the study period has been revealed.
Optimizing photochromic reactions of hydrophobic copper-doped zinc sulfide nanocrystals
Authors: Kimura Mayu , Yoshioka Daisuke , Matsuhiro Kaori , Kobayashi Yoichi
Published: January 2025

Copper-doped zinc sulfide nanocrystals (Cu-ZnS NCs) exhibit durable, temperature-stable photochromic properties with cost-effective synthesis. However, existing photochromic Cu-ZnS NCs are water-soluble, limiting industrial applications. Here, we synthesized hydrophobic Cu-ZnS NCs using ligands compatible with organic solvents. These NCs display reversible photochromism in several organic solvents, changing from pale yellow to brown under 365 nm light and reverting within tens of minutes. We systematically examined the effects of zinc precursors, particle size, Cu doping concentration, and solvents to optimize the performance and elucidate an optimal coloration condition. This study demonstrates the promise of Cu-ZnS NCs as versatile, next-generation photochromic materials.
Keputusan Berinvestasi Secara Digital di Siswa Sekolah Menengah
Authors: Susanti Eka Nana , Alimudin Muhamad
Published: January 2025

Investment is an activity that can be undertaken by anyone. Recently, numerous investment models have emerged in the digital world. The variety of investment models requires individuals to be cautious in selecting the right investment. For students, understanding financial literacy is crucial to avoid making poor investment decisions. This study aims to identify students' knowledge about investments and determine the influence of financial literacy on investment decision-making. The research employs a quantitative method with 91 respondents. Data analysis includes validity tests, reliability tests, simple linear regression, t-tests, and F-tests. The results of the study indicate that the partial test (t-test) yielded a t-value of 3.350, exceeding the t-table value of 1.985, with a significance level of 0.000 (3.350 > 1.985 and 0.000 < 0.05), suggesting that H0 is rejected and H1 is accepted. This indicates that financial literacy significantly influences investment decision-making. The simultaneous F-test shows that financial literacy has a positive simultaneous influence on investment decision-making, as indicated by an F-value of 13.476, exceeding the F-table value of 3.84, with a significance level of 0.000 (13.476 > 3.84 and 0.000 < 0.05). It can be concluded that financial literacy simultaneously influences investment decision-making.
Strategi Mitigasi Pembiayaan Bermasalah pada BSI RFO Medan
Authors: Mahvi Muhammad Rizky , Siregar Muhammad Habibi
Published: January 2025

This study aims to explore and analyze the non-performing financing mitigation strategies implemented by Bank Syariah Indonesia (BSI) Regional Finance Office (RFO) Medan. Using qualitative methods and case study approaches, this study explores the experiences and mitigation practices carried out by BSI management in handling non-performing financing. The data was obtained through in-depth interviews with managers and relevant officers at BSI RFO Medan as well as analysis of relevant documents. The main findings show that BSI RFO Medan implements various mitigation strategies which include financing restructuring efforts, stricter monitoring, and a personal approach with customers. However, challenges such as inconsistencies between the bank's internal policies and external conditions, as well as the low level of customer understanding of sharia financing, are obstacles to the effectiveness of the strategy. This study recommends the need to increase education to customers, improve the monitoring system, and strengthen communication between banks and customers to reduce the potential for non-performing financing in the future.
Analisis Penerapan Good Government Governance pada Pengelolaan Anggaran Pendapatan dan Belanja Desa (Studi Kasus pada Desa Pematang Johar, Kabupaten Deli Serdang)
Authors: Aldiansyah Ferdy , Wirananda Henny Andriyani
Published: January 2025

This study aims to analyze the application of good government governance principles in the management of APBDes in Pematang Johar Village, Deli Serdang Regency starting from the planning, implementation, administration, as well as reporting and accountability stages. Researchers take three principles of good government governance which are used as variable indicators, including transparency, participation and accountability. The subjects in this study include the Chairman / Member of BPD, Village Head, Village Secretary and Treasurer, and community leaders of Pematang Johar Village. Research design is a guideline or procedure and technique in research planning that is useful as a guide for building strategies that produce research models. The research design conducted in this study is a qualitative method. Data collection techniques in this study used observation, interview and documentation methods. The data analysis method used in this study is qualitative descriptive analysis. The result of this study is that the management of APBDes in Pematang Johar Village, Deli Serdang Regency is broadly in accordance with the principles of good government governance, namely transparency, participation and accountability.
Optimasi Website Sampurna Berkah dengan Framework Scrum Menggunakan Metode Agile untuk Meningkatkan Penjualan
Authors: Pratiwi Aniec Anafisah , Tanfitra Adhim , Waluyo Bibit , Abid Umar Abdul , Tarwoto
Published: January 2025

Waste management has become a complex national issue in Indonesia, driven by population growth, economic expansion, and shifting consumption patterns. The Sampurna Berkah website, owned by Sidapurna Village, Dukuhturi District, Tegal Regency, was created to support an environmentally conscious community focused on recycling non-biodegradable waste. To effectively develop the information system for this website, an agile approach is essential. The Scrum framework is employed to enhance transparency, communication, documentation, and adaptability to change. This study aims to optimize the Sampurna Berkah website, which has existing issues such as a confusing user interface, unsuitable color combinations, and lack of responsiveness. Using the Agile Scrum method, stages like Product Backlog, Sprint Planning, Sprint Backlog, Daily Scrum, and Sprint Review were implemented. The optimization results show significant improvements, including a more user-friendly interface, better website responsiveness, and more visually pleasing color combinations, achieving the main development objectives.
Pengaruh Artificial Intelligence Berbasis Chat terhadap Efektivitas dan Efisiensi Penyelesaian Masalah Pembelajaran di Tingkat Perguruan Tinggi
Authors: Angruningrum Erinna , Meitridwiastiti Anak Agung Ayu , Pratama Muhammad Ahyar , Utami Luh Putu Rika , Ameria Dewa Ayu Dinar Kartika , Putra Kadek Prema Sadhana
Published: January 2025

Penelitian ini bertujuan untuk mengevaluasi efektivitas dan efisiensi penggunaan kecerdasan buatan (AI) dalam lingkup perguruan tinggi serta melihat seberapa penting peranan kecerdasan buatan (AI) dalam menyelesaikan masalah di lingkungan perguruan tinggi. Penelitian akan melibatkan survei dan wawancara kepada individu yang memiliki pengalaman dalam penerapan AI di perguruan tinggi. Penelitian ini juga akan menggunakan metode Unified Theory of Acceptance and Use of Technology (UTAUT) sebagai arahan dalam pembuatan survei pertanyaan yang akan disebarkan ke responden. Tujuan dari penelitian ini adalah untuk memberikan pemahaman yang lebih baik tentang seberapa cepat dan efektif AI dapat menyelesaikan masalah di lingkungan perguruan tinggi. Penelitian ini akan menggunakan pendekatan kualitatif dan kuantitatif, dimana hasil penelitian akan dijelaskan secara kualitatif melalui wawancara dan secara kuantitatif melalui analisis statistik Regresi Linear Sederhana dari hasil responden yang didapatkan.
Dinamika Regulasi Komunikasi Publik dalam Sistem Sosial: Perspektif Autopoiesis Luhmann
Authors: Chandra Rudy , Sazali Hasan
Published: January 2025

This study aims to analyze the dynamics of public communication regulation in the social system from the perspective of Luhmann's autopoiesis. This study uses a qualitative method with a library research approach. The data of this study is sourced from relevant literature. Data analysis is carried out by reducing data, presenting data, and drawing conclusions. The validity of the data in this study was carried out through a credibility test. The results of this study show that in the dynamics of public communication regulation in the social system based on Luhmann's autopoiesis perspective, public communication regulation functions to maintain a balance between information disclosure, control, and system adaptability to rapid social change. Luhmann emphasized that public communication systems must continue to produce and reproduce elements that ensure their functions continue to function, such as transparency, trust, and responsiveness. Adaptive regulations allow the government to interact effectively with the public, especially in the digital era which presents challenges such as misinformation, disinformation, and rapid information flow. Cross-sector collaboration and regulatory flexibility are needed to maintain social stability and strengthen the relationship between the government and society, with information disclosure as a key pillar. However, the regulation must also include privacy protection and control over the spread of invalid information, so that public communication systems remain relevant, accountable, and able to adapt to evolving social dynamics.
Il clitico la nei verbi procomplementari
Authors: Ondelli Stefano
Published: January 2025

Alcuni lettori si domandano a che cosa si riferisca il pronome la in verbi come avercela, prendersela, farcela, sentirsela ecc., ma anche in espressioni più complesse come dirla schietta, mettercela tutta, pagarla cara, vedersela brutta ecc. In tutti i questi casi il pronome è declinato al femminile ed è obbligatorio, mentre di norma il pronome neutro è il maschile lo.
Diabetes care and comorbidities: the key in the multidisciplinary and multiprofessional approach
Authors: Gottardi, C.
Published: January 2025

Il mondo della cronicità è in progressiva crescita epidemiologica con notevole impegno di risorse, necessità di continuità assistenziale e forte integrazione tra professionisti sanitari e setting di cura. All’interno del PNRR, il DM 77 del 23/5/2022 identifica nelle Case di Comunità la sede privilegiata per l’erogazione di interventi integrati, multidisciplinari e multiprofessionali, che coinvolga ambulatori specialistici ed infermieristici, la medicina generale e le strutture distrettuali, usufruendo delle necessarie dotazioni tecnologiche, inclusa la telemedicina. La diabetologia si trova, quindi, di fronte ad una sfida complicata: prendersi cura del malato con diabete all’interno di un complesso profilo di comorbidità in un equilibrio clinico precario, estendendo le proprie conoscenze oltre lo specifico ambito diabetologico, talvolta superspecialistico, onde evitare una frammentazione, ridondanza e potenziale contrasto dei percorsi diagnostico-terapeutico-assistenziali. Il Dipartimento Specialistico Territoriale, recentemente creato nell’Azienda Sanitaria Universitaria Giuliano Isontina mira a promuovere la cosiddetta “Value Based Medicine”, cioè una medicina efficace ma sostenibile, sia in termini economici sia in termini di valori individuali e sociali, conciliante le linee guida con gli effettivi bisogni del paziente. L’obiettivo finale è quello di un programma di medicina di iniziativa con sistematica stratificazione dei pazienti a maggiore rischio/complessità per il governo clinico del sistema e la pianificazione dell’attività in modo efficiente, appropriato e sostenibile. PAROLE CHIAVE diabete; comorbidità; assistenza; multidisciplinarità; multiprofessionalità.
A rare case of autoimmune insulin syndrome in pregnancy: the complex management of glycemic control
Authors: Caroli, A.
Published: January 2025

La sindrome di Hirata è una forma rara di ipoglicemia causata da au-toanticorpi leganti insulina, spesso secondaria all’uso di acido alfa-li-poico(1). Risulta particolarmente insidiosa in gravidanza, in quanto gli anticorpi IgG possono attraversare la placenta. Sulla base delle nostre conoscenze riportiamo uno dei primi casi sindrome di Hirata in gra-vidanza: una donna del Mali di 28 anni con episodi di ipoglicemia a partire dalla 24° settimana gestazionale (GW) e anamnesi positiva per consumo di acido alfa lipoico. La positività degli anticorpi anti-insulina ha confermato la diagnosi. La terapia con predniso-ne è risultata efficace nel ridurre le ipoglicemie ma è stata causa di innalzamento dei valori glicemici al di sopra delle soglie consentite in gravidanza, ren-dendo necessario l’avvio di terapia con metformina. La gravidanza si è conclusa a 36+2 GW con nascita di un feto di sesso femminile. Gli anticorpi anti-in-sulina erano ancora positivi al momento del parto e la bambina ha sviluppato una forma secondaria di Sindrome di Hirata. PAROLE CHIAVE sindrome ipoglicemica autoim-mune; gravidanza; acido lipoico; ipoglicemia.
Makro- und mikrohämodynamische Beeinflussungen im Freitauch-Everesting Weltrekord.
Authors: Schedler Olaf , Weßhoff Daniel
Published: January 2025

Das Everesting ist eine neue Ausdauersportart, bei welcher die Sportler über eine definierte, jedoch frei wählbare Strecke am Berg eine kumulative Höhe von 8848 Metern zurücklegen. Eine Überwindung der Gesamtstrecke im Apnoe Tauchsport gab es bisher nicht. In einem Tauchturm von 20 Meter Wassertiefe wurden vom Freitaucher insgesamt 222 Apnoetauchgänge in 12:57:09 Stunden durchgeführt. Untersucht wurde der transkutane Sauerstoffpartialdruck (TINA 4, Radiometer, Kopenhagen), die Pulswellentransientzeit (PWTT) zur Kalkulation des Herzzeitvolumens und Standard Monitoring mit EKG, RR, SpO2 (Life Scope, BSM 6501, Nihon Kohden, Japan) sowie die Mikrozirkulation (O2C, LEA Medizintechnik Giessen, Deutschland) und die Bestimmung der Körperkerntemperatur mittels Infrarotthermometrie im Gehörgang. Vor dem Wettkampf lag ein transkutaner Sauerstoffdruck von 83 mmHg vor, welcher sich mit den ersten 50 Tauchgängen steigerte, um im weiteren Wettkampf nahezu konstant zu bleiben. (Mean=129,9±20,39 Standardabweichung). Die Werte folgen mit einem Bestimmungsmaß von R² = 0,3255 einer Potenzgleichung mit der Formel y = 104,24x0,1367. Der Perfusionsindex nimmt im Verlauf des Untersuchungszeitraumes signifikant zum Ausgangswert ab (p<0,01, t-Test) und ändert sich während des Wettkampfes nicht signifikant (p>0,05, t-Test). Die Pulswellentransientzeit und der Herzindex zeigten im Untersuchungszeitraum zur Ausgangsmessung keine signifikanten Unterschiede (p>0,05, t-Test). Entsprechend dem Gasgesetz von Dalton, ändern sich die Partialdrücke nur innerhalb des Gesamtdruckes. Durch die Erhöhung des Wasserdampfpartialdruckes um 23 mmHg sowie der Ausatmung von Kohlendioxid von 35 mmHg, erfolgt bei den Apnoetauchgängen im Freitauch Everesting keine Stickstoffaufsättigung des Gewebes. Die Abnahme des Perfusionsindex, die Abnahme des Blutflusses im Gewebe sowie die Abnahme der Sauerstoffsättigung in Gewebe lassen, bei gleichbleibenden Hämoglobingehalt, auf eine hydrostatisch bedingte periphere Vasokompression schließen. Die damit bedingte thorakale Volumenverschiebung zeigten in den Messungen des Herzindex der Makrohämodynamik und der Messungen der Mikrohämodynmaik keine signifikanten Beeinflussungen.
Early Warning Score in Notaufnahmen.
Authors: Schedler Olaf
Published: January 2025

Die Einführung des Early Warning Score (EWS) innerhalb eines Klinikkonzerns hat gezeigt, dass eine Reduzierung der innerklinischen Reanimationen um 5,2 % durch Risikostratefizierung erreicht werden konnte. Durch die Nutzung der EWS als Aufnahmeparameter einer Notaufnahme konnte im Verlauf der EWS als wichtiger Monitoringparameter ermittelt werden, da der EWS Punktwert sowohl signifikant die Behandlungszeit in der Notaufnahme (33 Minuten pro EWS Punktwert), sowie dass Potential der Veränderung des EWS Wertes (0,75 pro EWS Punktwert) zur weiteren stationären Behandlung (3,5 Verweildauertage pro EWS Punktwert) beeinflusst. Patienten der EWS Gruppe 4 waren im Rahmen ihrer stationären Behandlung besonders gefährdet, da eine erhöhte Verlegung und eine erhöhte Todesrate die Folge waren.
Functional analysis of ventilators under hyperbaric conditions.
Authors: Schedler Olaf , Stein Eberhard
Published: January 2025

38.553 air rescue missions are flown every year. 16.5% (n = 6347) of the inserts concern of disorders of the respiratory function with acute dyspnea. 5.7% of the rescue (n = 1924) are carried out specifically because of diseases of the lungs, resulting in a total of 3560 treatment cases (9.2%) leads to the implementation of mechanical ventilation therapy. This therapy with ventilators takes place during the helicopter flight in 28.8% with Emergency and in 71.3% with ventilators from intensive therapy. Notfallrespiratoren are portable ventilators with a limited range of functions. If ventilations performed they take place in 16.6% as volume-controlled ventilation and in 14.6% as a pressure-controlled ventilation. Only in 2.5% of cases of treatment assisted ventilation is performed. In 66.3% was no differentiation of mechanical ventilation therapy. Thus about 10,000 individual measurements were carried out by 7 ventilators in 5 height profiles and 7 measurements per device. It is certain that no one breathing gas distribution Kompaktrespirator Oxylog 3000 in Zweikompartmentmodell in volume controlled mode for 750 ml with 341.254 ml * s may specify.
Selective suppression of influenza A/H5N1 virus replication in vitro using nanocomplexes consisting of siRNA and aminopropylsilanol nanoparticles
Authors: Repkova Marina N. , Levina Asya S. , Mazurkov Oleg Yu. , Makarevich Elena V. , Filippova Ekaterina I. , Mazurkova Natalya A. , Zarytova Valentina F.
Published: January 2025

Relevance. Studies on model systems have confirmed the effectiveness of antisense oligonucleotides, including those that contain photoactive groups, for the modification of nucleic acids. However, this strategy has not yet found wide application due to the lack of successful methods for the intracellular delivery. The development of effective preparations capable of acting on target nucleic acids in cells is an urgent task.
The aim of the study is to create nanocomplexes consisting of aminopropylsilanol nanoparticles and short interfering RNA (siRNA) to study their effect on target nucleic acids by the example of inhibition of influenza A virus replication in vitro.
Materials and methods. MDCK cells, influenza virus A/chicken/Kurgan/05/2005 (A/H5N1), aminopropylsilanol nanoparticles, and native and modified siRNA molecules.
Results and discussion. We have prepared unique Si~NH2/siRNA nanocomplexes, which consist of aminopropylsilanol nanoparticles and siRNA molecules, which enable cell penetration and selective interaction with target nucleic acids, respectively. The antiviral activity of the proposed nanocomplexes has been studied on MDCK cells infected with the influenza A/H5N1 virus. It has been shown that the double-stranded siRNA molecules in the nanocomplexes, which act by the RNA interference mechanism, are more efficient in inhibiting the replication of the influenza virus than the corresponding single-stranded RNA fragments. The most effective nanocomplex that contained siRNA targeted at the chosen region of mRNA segment 5 of the viral genome reduced virus replication in the culture by a factor of 630. We have shown that non-agglomerated and water-soluble aminopropylsilanol nanoparticles are low-toxic, capable of delivering siRNA into cells and protecting siRNA in the Si~NH2/siRNA nanocomplexes from hydrolysis by cellular nucleases.
Conclusion. The biological activity of the created nanocomplexes has been demonstrated by the example of highly effective selective suppression of influenza A/chicken/Kurgan/05/2005 virus replication in the cellular system.
Protective potential of structural proteins of the SARS-CoV-2 virus in protecting against COVID-19
Authors: Dolzhikova Inna V. , Grousova Daria M. , Zorkov Ilya D. , Ilyukhina Anna A. , Kovyrshina Anna V. , Zubkova Olga V. , Popova Olga D. , Ozharovskaya Tatiana A. , Zrelkin Denis I. , Savina Daria M. , Samokhvalova Ekaterina G. , Tukhvatulin Amir I. , Shcheblyakov Dmitry V. , Logunov Denis Yu. , Gintsburg Alexander L.
Published: January 2025

Introduction. Many different vaccines for the prevention of COVID-19 have received emergency use approval in the shortest possible time. Due to the high rate of variability of the pathogen, in this study we analyzed the variability of the structural proteins of the SARS-CoV-2 virus and compared their protective potential in protecting animals from COVID-19.
The aim of the study was to compare the protective potential of the SARS-CoV-2 structural proteins in protecting animals from COVID-19.
Materials and methods. The SARS-CoV-2 virus was used in the study. Transgenic mice B6.Cg-Tg(K18-ACE2)2Prlmn/J (F1) were used as model animals. Recombinant adenoviral vectors rAd5-S, rAd5-N, rAd5-M were used for immunization of animals. Various genetic, virological and immunological methods, as well as methods of working with animals, were used in the study.
Results. The largest number of amino acid substitutions in the structural proteins of different SARS-CoV-2 variants was detected in glycoprotein S, the smallest — in nucleoprotein N. In the COVID-19 animal model, it was shown that only the use of glycoprotein S as a vaccine antigen allows to form protective immunity that protects 100% of animals from a lethal infection caused by the SARS-CoV-2 virus, while the use of protein N protects 50% of animals from a lethal infection, and protein M does not have a protective potential.
Conclusion. The data obtained, as well as the analysis of the epidemiological efficacy of various mRNA and vector vaccines, demonstrate that the use of the SARS-CoV-2 glycoprotein S as an antigen allows to form the highest level of protection. Due to the constant change in circulating variants of the SARS-CoV-2 virus, the decrease in the effectiveness of the vaccines with the original antigen composition against new variants of the virus and the continuing high incidence of COVID-19, it is necessary to continuously monitor the effectiveness of vaccines against new variants of the virus and promptly update the antigen composition of vaccines when a decrease in effectiveness is detected.
Segmenting Small Blood Vessels in MRA/MRI: A Machine Learning Approach with Bilateral Filtering Integration
Authors: Mohammed Shartaj Fatima
Published: January 2025

The adoption of artificial intelligence (AI) in various sectors, including healthcare, has gained significant popularity due to its potential to improve services. In the medical field, misdiagnosis has been a major problem, leading to increased mortality rates. Accurate diagnosis is crucial for effective treatment and management of diseases. This research aims to develop a machine-learning model for segmenting small blood vessels in magnetic resonance angiography (MRA) and magnetic resonance imaging (MRI) datasets using bilateral filtering. The research identifies the limitations of existing machine learning models in blood vessel segmentation, particularly the loss of important edge information due to convolutions that blur images. To address this issue, a non-linear bilateral filter is introduced to enhance the segmentation of blood vessels in MRI images. The proposed framework aims to improve the accuracy of the segmentation algorithm by reducing image blurring and noise through bilateral filtering. The objectives of this research include training and testing a machine-learning prototype using bilateral filtering, exploring the weaknesses of existing models in blood vessel segmentation, and developing a machine-learning model specifically designed for segmenting small blood vessels using bilateral filtering. Various studies have proposed machine learning algorithms, such as convolutional neural networks, for blood vessel segmentation. The review emphasizes the importance of bilateral filtering in improving classification accuracy by reducing image blurring. In conclusion, this research aims to contribute to the field of medical image analysis by developing a framework that utilizes bilateral filtering to enhance the segmentation of small blood vessels in MRA and MRI datasets. The proposed machine learning model has the potential to improve the accuracy of blood vessel segmentation, enabling more accurate diagnoses and reducing misdiagnosis-related mortality rates.
Beugrástól a lét-tehermentesítésig : Le nem vont konzekvenciák a Lét és időben
Authors: Beck Tamás
Published: January 2025

Minthogy máris több könyvtárnyi szakirodalom foglalkozik Martin Heidegger korszakalkotó művével, a Lét és idővel, nehéz fellelni a benne kifejtett gondolatok közül olyat, melynek konzekvenciái még nem kerültek maradéktalanul levonásra a szakemberek részéről. Meggyőződésem, hogy egy erre irányuló kísérlet mégsem reménytelen, csaknem száz esztendővel a szóban forgó munka megjelenését követően sem. A következő előadásban olyan következtetések levonására vállalkozom, melyek reményeim szerint markánsan árnyalják Heideggernek a Dasein létszerkezetére vonatkozó nézeteit, thanatológiai relevanciájuk révén pedig végső soron hozzájárulnak a végesség heideggeri koncepciójának megértéséhez, melyben nincs helye a halál utáni élet semminemű képzetének.
Egy (emlék)kötet mimézise
Authors: Rancz Mónika
Published: January 2025

A jóindulat hermeneutikája. Irodalmi, történeti, fenomenológiai
megközelítések. Szerk. Jani Anna‒Lengyel Zsuzsanna Mariann.
L’Harmattan Kiadó, Budapest, 2023. 486 oldal
A szeretet helye Søren Kierkegaard gondolkodásában
Authors: Lang Mark
Published: January 2025

A szeretet nem az erkölcsfilozófia fogalma, hanem par excellence vallási fogalom. Talán éppen ezért esik túl kevés szó róla a Kierkegaard-recepcióban, noha a fogalom végigvonul az egész életművön, sőt a dán szerző külön művet is szentel neki, a Szeret cselekedeteit. A német idealizmusban emelkedett a vallásfilozófia a szeriőz filozófia rangjára, és vált a filozófiai gondolkodást megtermékenyítő forrássá. Elég talán, ha csak Kantra gondolunk. Viszont a gyökeres rosszon túl, éppannyira fontos, ha egyenesen nem fontosabb a szeretet fogalma. Tanulmányomban azt szeretném megvizsgálni, hogy hogyan értelmezhető filozófiai összefüggésben a kierkegaard-i szeretetfogalom, a probléma megvilágításában pedig a német idealizmusban, elsősorban J. G. Fichte felfogásában értelmezett szeretet-felfogást fogom segítségül hívni.
Élet, elme, mesterséges intelligencia
Authors: Papp Levente
Published: January 2025

Munkám központjában álló teoretikus probléma az életnek, mint sajátos szerveződésnek és létmódnak (metabolizmus, homeosztázis) az elme megalapozásában betöltött esetleges vagy szükségszerű jellegét firtatja. Bemutatom röviden a nézetet, miszerint az életnek, mint biológiai organizációnak kulcsfontosságú szerep jut a pszichológiai értelemben vett autonóm teleológia (saját célszerűség) megalapozásában, majd kifejezésre juttatom a kételyt, miszerint egyáltalán nem világos, hogy ezt a szerepet hogyan tudná biztosítani az élettelen gépi létmód. Tanulmányomban a gondolkodó élettelen gép fogalmának egy alapvető problémájára hívom fel a figyelmet.
Growth and Yield of Sweet Corn Plants (Zea mays L Var saccharata.) Effect of Providing Various Nitrogen Sources and Pruning Techniques
Authors: Nazirah Laila
Published: January 2025

Corn is a vital food component primarily due to its high carbohydrate content. This research examines the effects of various nitrogen sources and pruning methods on the growth and yield of sweet corn. The investigation occurred in Tambon Tunong Village, located in the Dewantara District of North Aceh Regency, and in the Laboratory of the Faculty of Agriculture at Malikussaleh University from February to May 2024. A randomized block design (RAK) was employed for the experimental setup, incorporating two main factors: nitrogen sources (ZA fertilizer, HX Nitro fertilizer, and Urea fertilizer) and pruning methods (No Pruning, Pruning at 45 days after sowing (HST), and Pruning at 55 HST). Nine treatment combinations were evaluated, each replicated three times, resulting in 27 experimental units with 15 plants per unit, culminating in 405 plants. The findings indicated that urea fertilizer at 300 kg/ha produced the most favorable results regarding plant height, stem diameter, cob weight, and overall corn yield (10.79 tons/ha). Additionally, pruning at 45 HST resulted in the highest measurements for stem diameter, leaf count, and corn yield (7.81 tons/ha).
DAYA HAMBAT EKSTRAK ETANOL KULIT BUAH PISANG KEPOK MENTAH (Musa paradisiaca forma typica) TERHADAP PERTUMBUHAN Escherichia coli SECARA IN VITROÃƒâ€šÃ‚Â¬
Authors: Ariani Novia , Norjannah Norjannah
Published: January 2025

Tanaman pisang merupakan tanaman yang paling banyak dihasilkan dan dimanfaatkan oleh masyarakat Indonesia. Tanaman pisang memiliki berbagai macam jenis salah satunya pisang kepok. Kulit buah pisang kepok sudah banyak digunakan untuk pemanfaatan olahan pangan, namun untuk pemanfaatan sebagai obat masih terbatas padahal dalam kulit pisang mengandung metabolit sekunder flavonoid, alkaloid, saponin dan tanin yang memiliki aktivitas antibakteri. Tujuan penelitian ini adalah untuk mengetahui daya hambat ekstrak etanol kulit buah pisang kepok mentah (Musa paradisiaca forma typical) terhadap pertumbuhan Escherichia coli secara in vitroÃƒâ€šÃ‚Â­.Jenis penelitian ini adalah non eksperimental dengan metode sumuran yang dilakukan di laboratorium Mikrobiologi Akademi Farmasi ISFI Banjarmasin. Pengambilan sampel menggunakan teknik purposive sampling dengan kriteria tertentu. Penentuan daya hambat dengan melihat zona bening disekitar sumuran.Hasil penelitian menunjukkan bahwa ekstrak kulit buah pisang kepok mentah memiliki daya hambat terhadap pertumbuhan Eschericia coli secara in vitro.
EKSTRAK BAWANG PUTIH (Allium sativum L) SEBAGAI ZAT AKTIF PADA FORMULASI SEDIAAN GEL
Authors: Sopianti Densi Selpia , Bulan Putri Serindang
Published: January 2025

Bawang putih (Allium sativum L) memiliki julukan sebagai antibiotik alami. Aplikasi bawang putih pada wajah juga mempunyai beberapa manfaat yang bisa menyembuhkan jerawat (acne vulgaris). Tujuan penelitian ini membuat sediaan sediaan gel sebagai zat aktif yang digunakan yaitu ekstrak bawang putih (Allium sativum L). Metode dalam penelitian experimental laboratorium, dimana bawang putih sebagai bahan aktif diekstrak dengan menggunakan metode maserasi. Dibuat 3 variasi formula sediaan yaituÃƒâ€šÃ‚Â  3%, 5%, dan 7% dan zat tambahan lain dalam sediaan gel menggunakan bahan Na.CMC, nipagin dan nipasol, gliserol dan olium guajava. Masing-masing formula gel dilakukan evaluasi sediaan meliputi organoleptis, homogenitas, uji pH, uji daya sebar, dan uji iritasi. Hasil evaluasi sifat fisik gel dari ketiga formula dengan variasi ekstrak bawang putih pada konsentrasi yang berbeda dihasilkan formula I dengan konsentrasi ekstrak bawang putih 3% menghasilkan uji yang lebih baik dibandingkan Formila II dan formula III.
Usefulness of Comprehensive Genomic Profiling in Clinical Decision-Making in Oncology: A Systematic Review
Authors: Limaye Sewanti , Deshmukh Jayesh , Rohatagi Nitesh , Prabhash Kumar , Rauthan Amit , Singh Shambhavi , Kumar Arun
Published: January 2025

Biologic factors limiting responsiveness to matched targeted therapies include genomic heterogeneity and complexity. Advanced tumors with unique molecular profiles can be studied by comprehensive genomic profiling (CGP) and enhance patient outcomes using principles of precision medicine. The clinical utility of CGP across all cancer types and different therapeutic interventions using overall survival (OS) and progression-free survival (PFS) data was studied in this systematic literature review. Randomized controlled, nonrandomized, and observational studies conducted in adult patients with advanced cancer, dated up to September 2022, were searched from PubMed and EMBASE databases following PRISMA guidelines. Of 14 CGP studies, 7 (50%) and 9 (64%) reported OS and PFS as an outcome, respectively. Improved OS and PFS were reported when CGP guided treatment decisions, but its clinical utility varied among cancer types. Treatments were assigned based on matching scores and with the involvement of molecular tumor board (MTB) enhanced OS and PFS. Patients following MTB recommendations had superior treatment outcomes compared with those on physician’s choice regimens. CGP clinically benefited patients with genomically matched therapies and yielded better clinical outcomes regardless of cancer type. Further, uniform clinical value-based ranking of actionable mutations can encourage oncologists to use CGP tests for patients.
COMPARISON OF GOVERNMENT SYSTEMS BETWEEN MALAYSIAN AND INDONESIAN
Authors: Dian Dian Herlambang , Muhadi Muhadi , Muda Iskandar , Zildjianda Raesitha
Published: January 2025

In general, the Malaysian legal system is influenced by the British Common Law System legal tradition, while the Indonesian legal system adopts more of the Dutch civil law system tradition. In addition, the Islamic legal system and the customary law system also influence the national laws of each country. The comparative study of the constitutional law systems of Malaysia and Indonesia is a study of constitutional law using normative law research methods with a comparative law approach to examineWhat are the differences in the form of the state between Indonesia and Malaysia and how are the differences in the system of government between Indonesia and Malaysia. Based on the results of research through liberary research it was found that the institutional formats of Malaysia and Indonesia have differences both in terms of the form of the state and the system of government. Malaysia is a country that adheres to a federal type of state which includes a federal state and a state with a democratic monarchy system of government. While the State of Indonesia, in the form of a unitary state which includes central government and autonomous regions with a republican system of government with the principles of constitutional democracy.
THE IMPLEMENTATION OF EXTRA JURISDICTION HIJACKING
Authors: Rafi Darajati Muhammad
Published: January 2025

Plane hijacking is a relatively new form of crime; the motives behind the hijacking varied, ranging from economic to political. The international community considers that acts of hijack can threaten international peace and security. This article aims to discuss the efforts of the international community in the fight against this aircraft hijacking crime. The results showed that the international community's efforts were to make various conventions to protect international aviation activities. In the convention, the international community made various efforts to prevent and eradicate aircraft hijacks, such as allowing each country to expand its jurisdiction.
CORPORATE RESPONSIBILITY FOR ENVIRONMENTAL DEMAGE CAUSED BY THE OPERATIONAL ACTIVITIES OF PLANTATION AND PALM OIL INDUSTRY COMPANIES IN WEST KALIMANTAN
Authors: Mintarsih Endah , Yenny Oktavani , Tessa Jimmy , Safwatulloh Mochamad Indra
Published: January 2025

Environmental Pollution is a serious problem that is currently being experienced by the community due to the large number of companies that carry out operational activities, especially in the plantation and palm oil industries. As one of the provinces with the largest number of oil palm planters, West Kalimantan is a place for entrepreneurs who make investments in the oil palm plantation and industry sector. However, many companies that start their business do not fully comply with the provisions regarding the implementation of environmental protection as stipulated in Article 74 paragraph (1) of Law Number 40 of 2007 concerning Limited Liability Companies which confirms that companies carrying out their business activities in the natural resources sector and/ or fields related to natural resources must carry out social and environmental responsibility. This study aims to explain the social and environmental responsibilities of plantation companies and palm oil mills in West Kalimantan Province and the efforts made to resolve environmental disputes due to environmental damage by companies. The research method uses descriptive qualitative. Data collection was carried out by observation and in-depth interviews. The withdrawal of informants was done on purpose. Data analysis used Miles and Huberman's interactive model which began with data collection, data reduction, data presentation and drawing conclusions. The results of the study show that environmental pollution is increasing due to the large number of companies that have not carried out their responsibility to maintain the environment and carry out procedures according to the regulations in force.