bluuebunny/crossref_metadata_2025 huggingface dataset:
Difficult Respiratory Weaning after Cardiac Surgery: A Narrative Review
Authors: Nicolotti Davide , Grossi Silvia , Nicolini Francesco , Gallingani Alan , Rossi Sandra
Published: January 2023

Respiratory weaning after cardiac surgery can be difficult or prolonged in up to 22.7% of patients. The inability to wean from a ventilator within the first 48 h after surgery is related to increased short- and long-term morbidity and mortality. Risk factors are mainly non-modifiable and include preoperative renal failure, New York Heart Association, and Canadian Cardiac Society classes as well as surgery and cardio-pulmonary bypass time. The positive effects of pressure ventilation on the cardiovascular system progressively fade during the progression of weaning, possibly leading to pulmonary oedema and failure of spontaneous breathing trials. To prevent this scenario, some parameters such as pulmonary artery occlusion pressure, echography-assessed diastolic function, brain-derived natriuretic peptide, and extravascular lung water can be monitored during weaning to early detect hemodynamic decompensation. Tracheostomy is considered for patients with difficult and prolonged weaning. In such cases, optimal patient selection, timing, and technique may be important to try to reduce morbidity and mortality in this high-risk population.
Inhibin B-to-Anti-Mullerian Hormone Ratio as Noninvasive Predictors of Positive Sperm Retrieval in Idiopathic Non-Obstructive Azoospermia
Authors: Deng Chenyao , Liu Defeng , Zhao Lianming , Lin Haocheng , Mao Jiaming , Zhang Zhe , Yang Yuzhuo , Zhang Haitao , Xu Huiyu , Hong Kai , Jiang Hui
Published: January 2023

Background: The lack of clinically useful biomarkers for predicting micro-TESE outcomes in males with idiopathic NOA. To find clinically reliable serum reproductive hormone markers to predict the outcome of sperm retrieval in men with idiopathic NOA undergoing micro-TESE. Methods: We analyzed the clinical data of 168 men with idiopathic NOA treated with micro-TESE. The clinical predictors of a successful sperm retrieval were put to the test using logistic regression analysis. The clinical net benefit was calculated using a decision-curve analysis, and the predictive power of each variable was assessed using the ROC-derived area under the curve. Result: Between positive group and negative group for sperm retrieval, there was a statistically significant difference in INHB, AMH, and INHB/AMH. AMH, INHB, and INHB/AMH were each independent predictors of successful sperm retrieval, with INHB (OR1.02, p = 0.03), AMH (OR0.85, p = 0.01), INHB/AMH (OR1.08, p < 0.01). The ROC curve determined the optimal cut-off values for serum INHB and INHB/AMH in positive sperm retrieval patients undergoing micro-TESE. 21.51 pg/mL was the cut-off value for INHB. The cut-off value for INHB/AMH was 3.19, which had a 86.3% sensitivity and a 53.8% specificity. Using INHB and INHB/AMH prior to micro-TESE sperm retrieval in idiopathic NOA patients improved the net benefit of positive sperm retrieval, and the net benefit score of INHB/AMH was better than that of INHB, according to decision analysis curves. Conclusion: Serum INHB have predictive value for sperm retrieval outcomes in idiopathic NOA patients undergoing micro-TESE. Combining INHB and AMH, INHB/AMH seems to be a better predictor.
Development and Internal Validation of a Prediction Model for Surgical Success of Maxillomandibular Advancement for the Treatment of Moderate to Severe Obstructive Sleep Apnea
Authors: Visscher Wouter P. , Ho Jean-Pierre T. F. , Zhou Ning , Ravesloot Madeline J. L. , Schulten Engelbert A. J. M. , Lange Jan de , Su Naichuan
Published: January 2023

Background: Maxillomandibular advancement (MMA) has been shown to be the most effective surgical therapy for obstructive sleep apnea (OSA). Despite high success rates, there are patients who are considered as non-responders to MMA. In order to triage and inform these patients on their expected prognosis of MMA before the surgery, this study aimed to develop, internally validate, and calibrate a prediction model for the presence of surgical success for MMA in patients with OSA. Methods: A retrospective cohort study was conducted that included patients that had undergone MMA for moderate to severe OSA. Baseline clinical, polysomnographic, cephalometric, and drug-induced sleep endoscopy findings were recorded as potential predictors. Presence or absence of surgical success was recorded as outcome. Binary logistic regression analyses were conducted to develop the model. Performance and clinical values of the model were analyzed. Results: One hundred patients were included, of which sixty-seven (67%) patients reached surgical success. Anterior lower face height (ALFH) (OR: 0.93 [0.87–1.00], p = 0.05), superior posterior airway space (SPAS) (OR: 0.76 [0.62–0.92], p < 0.05), age (OR: 0.96 [0.91–1.01], p = 0.13), and a central apnea index (CAI) <5 events/hour sleep (OR: 0.16 [0.03–0.91], p < 0.05) were significant independent predictors in the model (significance level set at p = 0.20). The model showed acceptable discrimination with a shrunken area under the curve of 0.74, and acceptable calibration. The added predictive values for ruling in and out of surgical success were 0.21 and 0.32, respectively. Conclusions: Lower age at surgery, CAI < 5 events/hour, lower ALFH, and smaller SPAS were significant predictors for the surgical success of MMA. The discrimination, calibration, and clinical added values of the model were acceptable.
Eosinophilic Gastrointestinal Diseases in Inborn Errors of Immunity
Authors: Votto Martina , Naso Matteo , Brambilla Ilaria , Caimmi Silvia , De Filippo Maria , Licari Amelia , Marseglia Gian Luigi , Castagnoli Riccardo
Published: January 2023

Inborn errors of immunity (IEI) are disorders mostly caused by mutations in genes involved in host defense and immune regulation. Different degrees of gastrointestinal (GI) involvement have been described in IEI, and for some IEI the GI manifestations represent the main and characteristic clinical feature. IEI also carry an increased risk for atopic manifestations. Eosinophilic gastrointestinal diseases (EGIDs) are emerging disorders characterized by a chronic/remittent and prevalent eosinophilic inflammation affecting the GI tract from the esophagus to the anus in the absence of secondary causes of intestinal eosinophilia. Data from the U.S. Immunodeficiency Network (USIDNET) reported that EGIDs are more commonly found in patients with IEI. Considering this element, it is reasonable to highlight the importance of an accurate differential diagnosis in patients with IEI associated with mucosal eosinophilia to avoid potential misdiagnosis. For this reason, we provide a potential algorithm to suspect an EGID in patients with IEI or an IEI in individuals with a diagnosis of primary EGID. The early diagnosis and detection of suspicious symptoms of both conditions are fundamental to prevent clinically relevant complications.
Transcatheter Interventions for Atrioventricular Dysfunction in Patients with Adult Congenital Heart Disease: An International Case Series
Authors: Schamroth Pravda Nili , Vaknin Assa Hana , Sondergaard Lars , Bajoras Vilhelmas , Sievert Horst , Piayda Kerstin , Levi Amos , Witberg Guy , Shapira Yaron , Hamdan Ashraf , Perl Leor , Vig Shahar , Blieden Leonard , Kornowski Ran , Hirsch Rafael , Codner Pablo
Published: January 2023

Introduction: A substantial proportion of patients with adult congenital heart disease (ACHD) suffer from worsening valvular dysfunction in adulthood. Transcatheter valve interventions can offer a therapeutic alternative to surgery for those at high surgical risk. There is emerging but limited data on transcatheter interventions for atrioventricular (AV) valve dysfunction in patients with ACHD. Methods: We compiled an international collaborative multi-center registry focusing on adult patients with congenital heart disease undergoing transcatheter AV valve interventions (repair or replacement). Included were patients from three international centers who underwent procedures between 2016 and 2022. Demographic, clinical, and procedural data were compiled. Results: Nine patients with ACHD underwent AV valve interventions. The median age was 48 years (IQR (37; 56), 55% women). At baseline, seven patients (78%) were in NYHA functional class III and two (22%) were in NYHA functional class II. The diagnosis of ACHD varied. Three valve interventions were performed on the subpulmonary AV valve and six on the systemic AV valve. The primary valvular pathology was regurgitation (six patients, 78%). Five procedures were valve-in-valve interventions, and four procedures were transcatheter edge-to-edge repair procedures. There were no major complications or peri-procedural complications or peri-procedural mortality. One patient developed a suspected non-obstructive thrombus on the valve that was medically treated. One patient did not improve clinically following the procedure and underwent a heart transplant, one patient died 6 months following the procedure due to a cardiovascular implantable electronic device infection. At one year, six patients were in NYHA functional class I, and one patient was in NYHA functional class III. In conclusion, transcatheter AV heart valve interventions are feasible and safe procedures in carefully selected ACHD patients. These procedures can offer an effective treatment option in these younger patients with high surgical risk.
Incorporating Molecular Classification When Stratifying the Survival Risk of Patients with High-Grade Endometrial Carcinomas
Authors: Zong Liju , Mo Shengwei , Sun Zezheng , Lu Zhaohui , Chen Jie , Yu Shuangni , Xiang Yang
Published: January 2023

Assessing survival risk in patients with high-grade endometrial carcinomas has remained challenging. We aimed to investigate the distribution of molecular subtypes and assess their prognostic role in a large cohort of 355 patients with high-grade endometrial carcinoma. Molecular classification was determined using DNA polymerase epsilon (POLE) sequencing as well as immunohistochemical staining for p53 and mismatch repair (MMR) proteins. Endometrial carcinomas were stratified into four subtypes: POLE ultramutated, MMR-deficient, non-specific molecular profile (NSMP), and p53-mutant. This study included 177 and 178 patients with endometrioid and non-endometrioid carcinomas, respectively. Forty-two patients (11.8%) were categorized as POLE ultramutated, 106 (29.9%) as MMR-deficient, 128 (36.1%) as p53-mutant, and 79 (22.2%) as NSMP. Patients of different molecular subtypes had distinct survival times; molecular classification, but not histotype, was significantly associated with survival outcomes. When incorporating molecular classification into the stratification model, 52 patients (15.5%) switched risk groups, with 40 (11.9%) shifting to a lower risk for having a POLE mutation and 12 (3.6%) shifting to a higher risk owing to p53-mutant status. Molecular classification may provide more accurate prognostic information among patients with high-grade endometrial carcinomas and improve their stratification for purposes of clinical management.
Development of Clinical Decision Models for the Prediction of Systemic Lupus Erythematosus and Sjogren’s Syndrome Overlap
Authors: Han Yan , Jin Ziyi , Ma Ling , Wang Dandan , Zhu Yun , Chen Shanshan , Hua Bingzhu , Wang Hong , Feng Xuebing
Published: January 2023

Objective: To explore the clinical features of patients with systemic lupus erythematosus and Sjögren’s syndrome overlap (SLE-SS) compared to concurrent SLE or primary SS (pSS) patients, we utilized a predictive machine learning-based tool to study SLE-SS. Methods: This study included SLE, pSS, and SLE-SS patients hospitalized at Nanjing Drum Hospital from December 2018 to December 2020. To compare SLE versus SLE-SS patients, the patients were randomly assigned to discovery cohorts or validation cohorts by a computer program at a ratio of 7:3. To compare SS versus SLE-SS patients, computer programs were used to randomly assign patients to the discovery cohort or the validation cohort at a ratio of 7:3. In the discovery cohort, the best predictive features were determined using a least absolute shrinkage and selection operator (LASSO) logistic regression model among the candidate clinical and laboratory parameters. Based on these factors, the SLE-SS prediction tools were constructed and visualized as a nomogram. The results were validated in a validation cohort, and AUC, calibration plots, and decision curve analysis were used to assess the discrimination, calibration, and clinical utility of the predictive models. Results: This study of SLE versus SLE-SS included 290 patients, divided into a discovery cohort (n = 203) and a validation cohort (n = 87). The five best characteristics were selected by LASSO logistic regression in the discovery cohort of SLE versus SLE-SS and were used to construct the predictive tool, including dry mouth, dry eye, anti-Ro52 positive, anti-SSB positive, and RF positive. This study of SS versus SLE-SS included 266 patients, divided into a discovery cohort (n = 187) and a validation cohort (n = 79). In the discovery cohort of SS versus SLE-SS, by using LASSO logistic regression, the eleven best features were selected to build the predictive tool, which included age at diagnosis (years), fever, dry mouth, photosensitivity, skin lesions, arthritis, proteinuria, hematuria, hypoalbuminemia, anti-dsDNA positive, and anti-Sm positive. The prediction model showed good discrimination, good calibration, and fair clinical usefulness in the discovery cohort. The results were validated in a validation cohort of patients. Conclusion: The models are simple and accessible predictors, with good discrimination and calibration, and can be used as a routine tool to screen for SLE-SS.
The Evolution of Minimally Invasive Spine Tumor Resection and Stabilization: From K-Wires to Navigated One-Step Screws
Authors: Shiber Mai , Kimchi Gil , Knoller Nachshon , Harel Ran
Published: January 2023

Minimization of the surgical approaches to spinal extradural metastases resection and stabilization was advocated by the 2012 Oncological Guidelines for Spinal Metastases Management. Minimally invasive approaches to spine oncology surgery (MISS) are continually advancing. This paper will describe the evolution of minimally invasive surgical techniques for the resection of metastatic spinal lesions and stabilization in a single institute. A retrospective analysis of patients who underwent minimally invasive extradural spinal metastases resection during the years 2013–2019 by a single surgeon was performed. Medical records, imaging studies, operative reports, rates of screw misplacement, operative time and estimated blood loss were reviewed. Detailed description of the surgical technique is provided. Of 138 patients operated for extradural spinal tumors during the study years, 19 patients were treated in a minimally invasive approach and met the inclusion criteria for this study. The mortality rate was significantly improved over the years with accordance of improve selection criteria to better prognosis patients. The surgical technique has evolved over the study years from fluoroscopy to intraoperative 3D imaging and navigation guidance and from k-wire screw insertion technique to one-step screws. Minimally invasive spinal tumor surgery is an evolving technique. The adoption of assistive devices such as intraoperative 3D imaging and one-step screw insertion systems was safe and efficient. Oncologic patients may particularly benefit from the minimization of surgical decompression and fusion in light of the frailty of this population and the mitigated postoperative outcomes associated with MIS oncological procedures.
HMNet: Hierarchical Multi-Scale Brain Tumor Segmentation Network
Authors: Zhang Ruifeng , Jia Shasha , Adamu Mohammed Jajere , Nie Weizhi , Li Qiang , Wu Ting
Published: January 2023

An accurate and efficient automatic brain tumor segmentation algorithm is important for clinical practice. In recent years, there has been much interest in automatic segmentation algorithms that use convolutional neural networks. In this paper, we propose a novel hierarchical multi-scale segmentation network (HMNet), which contains a high-resolution branch and parallel multi-resolution branches. The high-resolution branch can keep track of the brain tumor’s spatial details, and the multi-resolution feature exchange and fusion allow the network’s receptive fields to adapt to brain tumors of different shapes and sizes. In particular, to overcome the large computational overhead caused by expensive 3D convolution, we propose a lightweight conditional channel weighting block to reduce GPU memory and improve the efficiency of HMNet. We also propose a lightweight multi-resolution feature fusion (LMRF) module to further reduce model complexity and reduce the redundancy of the feature maps. We run tests on the BraTS 2020 dataset to determine how well the proposed network would work. The dice similarity coefficients of HMNet for ET, WT, and TC are 0.781, 0.901, and 0.823, respectively. Many comparative experiments on the BraTS 2020 dataset and other two datasets show that our proposed HMNet has achieved satisfactory performance compared with the SOTA approaches.
A Randomized Study of Rigid Video Stylet versus Macintosh Laryngoscope for Double-Lumen Endobronchial Tube Intubation Assistance in Thoracoscopic Pulmonary Surgery
Authors: Gu Yang , Zhou Qing , Zhou Huanping , Liu Meiyun , Feng Di , Wei Juan , Min Keting , Zhu Wanli , Chen Yuanli , Lv Xin
Published: January 2023

Double-lumen endobronchial tube (DLT) intubation is more challenging than single-lumen tube intubation is, and the rigid video stylet (RVS) is one of the tools that has emerged to deal with this demanding intubation procedure. We evaluated whether the UE® RVS can shorten the DLT intubation time and improve the first-attempt intubation success rate compared with that of Macintosh laryngoscope (ML). A total of 130 participants scheduled to undergo thoracoscopic pulmonary surgeries were enrolled. They were randomized to receive either ML- or RVS-assisted DLT intubation. The primary outcomes were the intubation time and first-attempt intubation success rate. The secondary outcomes were the overall intubation success rate, mean arterial pressure, postoperative sore throat (POST), and postoperative hoarseness at 1 h and 24 h. Compared with the ML group, the intubation time was significantly shorter in the RVS group (p < 0.001; 30.82 ± 10.61 vs. 39.62 ± 6.54 s), however, the first-attempt success rate was significantly lower (p = 0.048; 83.08% vs. 95.16%). The POST at 1 h was less severe in the RVS group (p = 0.021). No significant differences were found for the other indicators. Among the patients with normal airways, the UE® RVS can achieve faster DLT intubation and decrease the severity of a POST at 1 h, although it was associated with a lower first-attempt intubation success rate.
Clionaterpene, a New Cadinene Sesquiterpene from the Marine Sponge Cliona sp.
Authors: Zhou Ying , Liang Huixian , Wang Zhaocong , Liao Xiaojian , Xu Shihai , Zhao Bingxin
Published: January 2023

Clionaterpene (1), a new cadinene sesquiterpene, along with six known compounds 2–7 were isolated from the marine sponge Cliona sp. The structure of 1 with absolute configuration was determined by the spectroscopic data (UV, IR, MS, and NMR) and quantum chemical calculation. Compound 1 was the first cadinene sesquiterpene metabolite isolated from this genus. In addition, the cytotoxic and antibacterial activities of these compounds were evaluated. However, none of them exhibited significant inhibition effects.
Improvement and Optimization Configuration of Inland Ship Power and Propulsion System
Authors: Du Zhipeng , Chen Qinan , Guan Cong , Chen Hui
Published: January 2023

Advances in power and propulsion and energy management improvements can significantly contribute to reducing emissions. The International Maritime Organization (IMO) Marpol regulations impose increasingly stringent restrictions on ship’s emission. According to the measured data of the target ship in typical working profiles, the power fluctuation, fuel consumption and emission data are analyzed, and the result represented that there are serious fuel consumption and pollution problems in the diesel engine power system. Based on the ship-engine propeller matching design theory, the ship-engine propeller model was built, and the new propulsion system power of the target ship was obtained by simulation. From the perspectives of power, economy and green, the performance and emission indexes of diesel engine and LNG engine are compared and analyzed, and the fuel cost advantage, green advantage and power performance disadvantage of LNG engine compared with diesel engine are determined. By comparing the topological structures of different hybrid propulsion forms, the new propulsion form of the ship is improved to be the gas-electric hybrid propulsion system based on the ESS (Energy Storage System), and the selection of the supercapacitors and lithium batteries is compared. Based on the low-pass filter strategy, the power distribution of the ultracapacitor and lithium battery is distributed. In order to determine the optimal ESS configuration, a capacity configuration model with investment cost, fuel cost and energy storage life as objective functions was established. NGSA-II algorithm was used to calculate the model and scheme selection was completed based on the scheme decision model. In this case, the optimal scheme significantly reduces pollutant emissions, it also reduces daily fuel costs by 38% and the result shows that we can complete the cost recovery in 1.28 years.
Experimental Assessment of Planing Hulls Added Resistance in Regular Waves
Authors: De Luca Fabio , Pensa Claudio , Pigazzini Riccardo
Published: January 2023

Amid a global effort in reducing the shipping ecologic impact, the study of the particular case of added resistance of high speed vessels cruising in a seaway has been approached by a very limited number of authors. In this study, we provide a comprehensive and systematic assessment of the added resistance of a planing hull in regular waves. The data are analyzed in both the time and frequency domains in order to fully characterize the added resistance and highlight its correlation with hull motions. It is found that peak added resistance modulation occurs for shorter waves with respect to the peak average added resistance, and slenderness is beneficial only in terms of modulation. Nonlinearity of both the average and first harmonic amplitude is also shown. In addition, results of the phase analysis show a correlation between the added resistance phase and average added resistance.
Larval Fish Spatiotemporal Dynamics of Different Ecological Guilds in Yangtze Estuary
Authors: Wan Rong , Song Pengbo , Li Zengguang , Long Xiangyu , Wang Dong , Zhai Lu
Published: January 2023

Estuaries, as important fish nursery habitats, usually include a variety of larval fishes of different ecological guilds and exhibit complicated changing environmental conditions. We carried out a survey to examine the spatiotemporal dynamics of different ecological guild larval fishes and their relationships with environmental factors in the springs and summers from 2018 to 2020 in the Yangtze Estuary (China). The aims of the study were to provide detailed information on the characteristics of the larval fish assemblage and to explore the spatiotemporal variation in different ecological guild species and the effects of environmental variables on assemblage structure. More than 140,000 fish larvae from 26 families and 99 species were gathered during the six cruises, with the spring being the most prolific. The assemblage was dominated by a few species and was divided into three ecological guilds. Engraulidae was the most abundant family, followed by Cyprinidae and Gobiidae. Hemiculter bleekeri (freshwater), Pseudolaubuca sinensis (freshwater), Coilia mystus (brackish water), and Engraulis japonicas (marine) were the predominant species. Seasonal variations in larval fish assemblage structure were closely influenced by temperature, and the fluctuation in salinity mainly determined the spatial distribution of the larval fish community. Freshwater flows also played an important role in shaping the larval fish assemblage structure and dynamics. The conclusions improve the understanding of the ecological dynamics of larval fish assemblages in environmentally heterogeneous areas and may be applicable to other estuary ecosystems.
A Multi-Objective Mission Planning Method for AUV Target Search
Authors: Yan Zheping , Liu Weidong , Xing Wen , Herrera-Viedma Enrique
Published: January 2023

How an autonomous underwater vehicle (AUV) performs fully automated task allocation and achieves satisfactory mission planning effects during the search for potential threats deployed in an underwater space is the focus of the paper. First, the task assignment problem is defined as a traveling salesman problem (TSP) with specific and distinct starting and ending points. Two competitive and non-commensurable optimization goals, the total sailing distance and the turning angle generated by an AUV to completely traverse threat points in the planned order, are taken into account. The maneuverability limitations of an AUV, namely, minimum radius of a turn and speed, are also introduced as constraints. Then, an improved ant colony optimization (ACO) algorithm based on fuzzy logic and a dynamic pheromone volatilization rule is developed to solve the TSP. With the help of the fuzzy set, the ants that have moved along better paths are screened and the pheromone update is performed only on preferred paths so as to enhance pathfinding guidance in the early stage of the ACO algorithm. By using the dynamic pheromone volatilization rule, more volatile pheromones on preferred paths are produced as the number of iterations of the ACO algorithm increases, thus providing an effective way for the algorithm to escape from a local minimum in the later stage. Finally, comparative simulations are presented to illustrate the effectiveness and advantages of the proposed algorithm and the influence of critical parameters is also analyzed and demonstrated.
Dynamic Traction of Deep-Sea Polymetallic Nodule Collector
Authors: Song Yuheng , Yin Shiyang , Zhang Ning , Lu Fengnian , Cheng Zexuan
Published: January 2023

The ocean is extremely rich in mineral resources. To cope with the shortage of land mineral resources, countries are focusing on the development of deep-sea mineral mining technology. Owing to its superior traction performance, the deep-sea polymetallic nodule collector (DPNC) has become the preferred solution for ocean mining. This paper proposes a dynamic traction calculation model to address the shortcomings in the classical static traction calculation model with consideration of the dynamic variation rule of grouser–soil interaction in the DPNC process. Lab tests were conducted to formulate materials similar to deep-sea soil, and the corresponding shear stress–displacement models were established using the discrete element method (DEM) and Magic Formula to describe the “shear stress–displacement” relationship more accurately. Considering Kunlong 500, which is a Chinese DPNC, as an example, the periodicity and dynamics of the dynamic traction force were analyzed and compared with the numerical simulation results. The dynamic traction force was smaller than the static traction force and fluctuated significantly when considering the dynamic grousers–soil interaction. The magnitude and fluctuation of the dynamic traction force were influenced by the ratio of the grouser height to the spacing. In the DPNC design, the ratio of the grouser height to the spacing should be optimized according to the properties of the deep-sea subsoil to improve the traction performance and stability of the DPNC.
Immersive and Non-Immersive Simulators for the Education and Training in Maritime Domain—A Review
Authors: Dewan Mohammud Hanif , Godina Radu , Chowdhury M Rezaul Karim , Noor Che Wan Mohd , Wan Nik Wan Mohd Norsani , Man Mustafa
Published: January 2023

In the domain of Marine Education and Training (MET), simulators have been utilized for the purpose of training seafarers in the norms for avoiding collisions or for developing the skill of ship manoeuvrability, and even the operation of machinery in the engine room, as well as for conducting research on the subject matter of ship structure, specialized vessel operation, working principle of equipment, and shipboard safety training. These tools are even more important when facing disruptive events such as the COVID-19 pandemic. In MET institutions, full-mission bridge and engine room simulators have been utilized for teaching seafarers for more than a decade. A Systematic Literature Review (SLR) was conducted to identify immersive and non-immersive simulator applications produced over the previous ten years to improve seafarers’ experiential teaching and learning, in the maritime domain. We retrieved 27 articles using the four stages of PRISMA paradigm: Identification, Screening, Eligibility, and Inclusion. The selected papers were read and analyzed according to the training type, the area of training, and the technologies used. The utilization of immersive and non-immersive simulators in the context of the MET domain has been identified and mapped. A few research studies (9 out of 27) compared immersive and non-immersive simulator-based training with conventional training. The quality and efficacy of immersive and non-immersive simulator training at MET institutions have been studied. A model from the learner’s perspective is essential and recommended for future research to assess efficiency and efficacy.
Experimental Study of the Dynamic Performance of Steel Catenary Riser within the Touchdown Zone
Authors: Yu Yang , Xu Shengbo , Yu Jianxing , Xu Lixin , Liu Xin , Liu Pengfei
Published: January 2023

This study proposed a novel experimental platform to conduct dynamic loading tests of a truncated model steel catenary riser (SCR) within the touchdown zone (TDZ). The facilities of the platform, including a soil tank, a loading system, and a soil stirring system, were introduced in detail. The parameters of the test were determined through the simulation of an in situ riser. A steel pipe was adopted as the model riser, with its outer diameter equaling that of the prototype SCR. Before executing the dynamic loadings, the model riser developed its static configuration under the submerged weight and applied bending moment. Subsequently, cyclic vertical and lateral displacement loads were applied to the truncated point. The test results showed that when the vertical loading amplitude increased from 200 mm to 300 mm, the stress ranges at the front of the model riser increased by more than 100%, whereas the stress range only differed by less than 5% under different loading periods. Numerical models of the SCR were built based on the vector form intrinsic finite element (VFIFE) method. High similarities between the test and simulation results proved the reliability of the nonlinear soil model and the numerical model. During the test, a seabed trench was developed with a depth of 0.71 D and a width of 0.48 D, and its shape was similar to the in situ trench.
Scale-Up of an Aquaculture Plant for Reproduction and Conservation of the Sea Urchin Paracentrotus lividus: Development of Post-Larval Feeds
Authors: Gharbi Maissa , Glaviano Francesca , Federico Serena , Pinto Bruno , Cosmo Anna Di , Costantini Maria , Zupo Valerio
Published: January 2023

Paracentrotus lividus gonads, often referred to as “roe” or “uni” for gastronomical purposes, are among the most appreciated seafood delicacies in the Mediterranean area and worldwide. However, the increasing demand for human consumption has caused a growing pressure on its wild stocks, prompting the need to develop efficient aquaculture systems for its production. The set-up of effective feeds for various life stages and optimal procedures for breeding post-larvae and adult sea urchins still need to be improved. Here, for the first time, we aim at developing artificial feeds for the post-larvae of P. lividus because a critical step to improve our productive skills is post-larval growth. We tested various natural and prepared components to speed up the growth and enhance the survival rates of post-larvae, while taking into account the abiotic and biotic factors influencing the culture conditions in three replicate sets of tanks, characterized by different volumes. We tested formulated feeds and compared them with the effect of fresh foods in the frame of canonical culture practices. Our results indicated the efficiency of a feed composed of spirulina and Ulva rigida. Statistical analyses demonstrated the positive impact of this diet on the growth of post-larvae, behavior and survival rates. In addition, we demonstrated the efficacy of prepared feeds in the sea urchin aquaculture system, because they facilitated manipulation and control of the culture procedures for the satisfactory growth of P. lividus post-larvae.
Epichloë Endophytes Shape the Foliar Endophytic Fungal Microbiome and Alter the Auxin and Salicylic Acid Phytohormone Levels in Two Meadow Fescue Cultivars
Authors: Mathew Suni Anie , Helander Marjo , Saikkonen Kari , Vankova Radomira , Dobrev Petre I. , Dirihan Serdar , Fuchs Benjamin
Published: January 2023

Plants harbor a large diversity of endophytic microbes. Meadow fescue (Festuca pratensis) is a cool-season grass known for its symbiotic relationship with the systemic and vertically—via seeds—transmitted fungal endophyte Epichloë uncinata, yet its effects on plant hormones and the microbial community is largely unexplored. Here, we sequenced the endophytic bacterial and fungal communities in the leaves and roots, analyzing phytohormone concentrations and plant performance parameters in Epichloë-symbiotic (E+) and Epichloë-free (E-) individuals of two meadow fescue cultivars. The endophytic microbial community differed between leaf and root tissues independent of Epichloë symbiosis, while the fungal community was different in the leaves of Epichloë-symbiotic and Epichloë-free plants in both cultivars. At the same time, Epichloë symbiosis decreased salicylic acid and increased auxin concentrations in leaves. Epichloë-symbiotic plants showed higher biomass and higher seed mass at the end of the season. Our results demonstrate that Epichloë symbiosis alters the leaf fungal microbiota, which coincides with changes in phytohormone concentrations, indicating that Epichloë endophytes affect both plant immune responses and other fungal endophytes. Whether the effect of Epichloë endophytes on other fungal endophytes is connected to changes in phytohormone concentrations remains to be elucidated.
URA3 as a Selectable Marker for Disruption and Functional Assessment of PacC Gene in the Entomopathogenic Fungus Isaria javanica
Authors: Zou Manling , Xin Bei , Sun Xin , Lin Runmao , Lu Junru , Qi Jing , Xie Bingyan , Cheng Xinyue
Published: January 2023

An effective selection marker is necessary for genetic engineering and functional genomics research in the post-genomic era. Isaria javanica is an important entomopathogenic fungus with a broad host range and prospective biocontrol potentials. Given that no antibiotic marker is available currently in this fungus, developing an effective selection marker is necessary. In this study, by applying overlap PCR and split-marker deletion strategy, combining PEG-mediated protoplasm transformation method, the uridine auxotrophy gene (ura3) in the I. javanica genome was knocked out. Then, using this transformation system, the pH response transcription factor gene (IjpacC) was disrupted successfully. Loss of IjpacC gene results in an obvious decrease in conidial production, but little impact on mycelial growth. The virulence of the ΔIjpacC mutant on caterpillars is similar to that of the wild-type strain. RT-qPCR detection shows that expression level of an acidic-expressed S53 gene (IF1G_06234) in ΔIjpacC mutant is more significantly upregulated than in the wild-type strain during the fungal infection on caterpillars. Our results indicate that a markerless transformation system based upon complementation of uridine auxotrophy is successfully developed in I. javanica, which is useful for exploring gene function and for genetic engineering to enhance biological control potential of the fungus.
Taxonomy and Phylogeny of Peniophora Sensu Lato (Russulales, Basidiomycota)
Authors: Xu Yun-Lin , Tian Yan , He Shuang-Hui
Published: January 2023

Peniophora is an old corticioid genus, from which two small satellite genera, Dendrophora and Duportella, were derived based on morphological differences. Molecular systematic studies showed that they belong to Peniophoraceae, Russulales, but the inter- and intra-generic phylogenetic relationships are still unclear. Moreover, the species diversity of this group in subtropical and tropical Asia has not been sufficiently investigated and studied. In this study, we carried out an intensive taxonomic and phylogenetic study on Peniophora sensu lato based on analyses of concatenated ITS1-5.8S-ITS2 (ITS, Internal Transcribed Spacer) and 28S (D1–D2 domains of nuc 28S rDNA) sequence data of all available species worldwide. In the phylogenetic trees, species of Peniophora s. l. (sensu lato) including types of Peniophora s.s. (sensu stricto), Dendrophora and Duportella were interspersed within a strongly supported clade. It means that the morphological delimitations of the three genera are not reliable, and they should be regarded as a large genus. As a result, eight species of Duportella were transferred to Peniophora, although five of them have not been sequenced. Four new distinct lineages, corresponding to Peniophora cremicolor, P. major, P. shenghuae and P. vietnamensis spp. nov., were recovered in the trees. Peniophora taiwanensis is treated as a later synonym of P. malaiensis based on morphological and molecular evidence. Duportella renispora is excluded from Peniophoraceae, because BLAST results of the ITS and 28S sequences of the holotype showed that it is closely related to Amylostereum. Descriptions and illustrations are provided for the four new species, and an identification key is given for all 25 species of Peniophora in China. Our results indicated that the species diversity of the corticioid fungi in Asia is rich and deserves further study.
FairEmbo Concept for Postpartum Hemorrhage: Evaluation of the Efficacy of Suture Fragment Compared with Gelatin Sponge Torpedo Embolization in a Post-Gravid Swine Model
Authors: Banata Gang-Ny Amandine , Panneau Julien , Brige Pauline , Hak Jean-François , Habert Paul , Vidal Vincent , Tradi Farouk , Di Bisceglie Mathieu
Published: January 2023

Background: Postpartum hemorrhage is the leading cause of maternal mortality in emerging countries. This study aims to evaluate the effectiveness and safety of uterine artery embolization (UAE) using suture fragment (FairEmbo concept) in a swine model. Methods: Seven female swine uteri were embolized. The left uterine artery was embolized with 1 cm fragments of absorbable suture (Optime® 0), and with gelatin sponge torpedoes for the contralateral side for comparison. The embolization effectiveness and the time for arterial recanalization with digital subtraction angiography (DSA) controls at D0, D7, and M1, were evaluated. Follow-up protocol also included clinical monitoring and macroscopical analyses at M1. A Mann–Whitney test (significance at P 0.05) was used for statistics. Results: A technical success was obtained for the seven arteries on each side, with no off-target embolization. The procedure time (10 min versus 3.7 min) and number of fragments (13.8 versus 5.7) required for complete occlusion were significantly greater in the FairEmbo group. All arteries were repermeabilized at M1. No necrosis was macroscopically visible at harvest at M1. Conclusion: This experimental study suggests that UAE with SBM FairEmbo method is feasible, safe, and effective in comparison with gelatin sponge procedure.
Three-Dimensional Accuracy and Stability of Personalized Implants in Orthognathic Surgery: A Systematic Review and a Meta-Analysis
Authors: Diaconu Alexandru , Holte Michael Boelstoft , Berg-Beckhoff Gabriele , Pinholt Else Marie
Published: January 2023

This systematic review aimed to determine the accuracy/stability of patient-specific osteosynthesis (PSI) in orthognathic surgery according to three-dimensional (3D) outcome analysis and in comparison to conventional osteosynthesis and computer-aided designed and manufactured (CAD/CAM) splints or wafers. The PRISMA guidelines were followed and six academic databases and Google Scholar were searched. Records reporting 3D accuracy/stability measurements of bony segments fixated with PSI were included. Of 485 initial records, 21 met the eligibility (566 subjects), nine of which also qualified for a meta-analysis (164 subjects). Six studies had a high risk of bias (29%), and the rest were of low or moderate risk. Procedures comprised either single-piece or segmental Le Fort I and/or mandibular osteotomy and/or genioplasty. A stratified meta-analysis including 115 subjects with single-piece Le Fort I PSI showed that the largest absolute mean deviations were 0.5 mm antero-posteriorly and 0.65° in pitch. PSIs were up to 0.85 mm and 2.35° more accurate than conventional osteosynthesis with CAD/CAM splint or wafer (p < 0.0001). However, the clinical relevance of the improved accuracy has not been shown. The literature on PSI for multi-piece Le Fort I, mandibular osteotomies and genioplasty procedure is characterized by high methodological heterogeneity and a lack of randomized controlled trials. The literature is lacking on the 3D stability of bony segments fixated with PSI.
Fundamental Knowledge on Forgotten Species: An Exploration of Data from Rarely Studied Captive Animals
Authors: Descovich Kris , Kemp Caralyn , Rendle Jessica
Published: January 2023

Zoological institutions contribute a large amount of fundamental and applied knowledge on a diverse array of animal species [...]
Contribution of High-Resolution Virtual Outcrop Models for the Definition of Rockfall Activity and Associated Hazard Modelling
Authors: Robiati Carlo , Mastrantoni Giandomenico , Francioni Mirko , Eyre Matthew , Coggan John , Mazzanti Paolo
Published: January 2023

The increased accessibility of drone technology and structure from motion 3D scene reconstruction have transformed the approach for mapping inaccessible slopes undergoing active rockfalls and generating virtual outcrop models (VOM). The Poggio Baldi landslide (Central Italy) and its natural laboratory offers the possibility to monitor and characterise the slope to define a workflow for rockfall hazard analysis. In this study, the analysis of multitemporal VOM (2016–2019) informed a rockfall trajectory analysis that was carried out with a physical-characteristic-based GIS model. The rockfall scenarios were reconstructed and then tested based on the remote sensing observations of the rock mass characteristics of both the main scarp and the rockfall fragment inventory deposited on the slope. The highest concentration of trajectory endpoints occurred at the very top of the debris talus, which was constrained by a narrow channel, while longer horizontal travel distances were allowed on the lower portion of the slope. To further improve the understanding of the Poggio Baldi landslide, a time-independent rockfall hazard analysis aiming to define the potential runout associated with several rock block volumetric classes is a critical component to any subsequent risk analysis in similar mountainous settings featuring marly–arenaceous multilayer sedimentary successions and reactivated main landslide scarps.
The Archeological Landscape of the Chanchán Basin and Its Agroecological Legacies for the Conservation of Montane Forests in the Western Foothills of the Ecuadorian Andes
Authors: Aguirre Merino Christiam , Piqué Huerta Raquel , Parra Ordoñez Lady , Guamán Cazho Verónica , Valdez Bustamante Walter
Published: January 2023

This article shows a set of agroecological practices that were incorporated into the archeological landscape of the Chanchán basin by pre-Hispanic Kañaris societies for 1200 years (240–1438 AD), a millennium before the arrival of the Incas, and that continue to be used in this landscape by certain indigenous communities of the 21st century. The use of archeobotanical techniques, contrasted with ethnobotanical sources, has allowed us to interpret how these societies structured their cultivation systems, agroecological practices, and landscape management, for the conservation of agroecosystems in the western Andean foothills. Agroecological legacies show how the stability, adaptability, and elasticity of Andean agriculture can be sustained under models of progressive intensification without this causing irreversible environmental damage in the agroecosystems. Kañaris agroecological practices configured the Chanchán landscape as a great cultural artifact, wherein the non-human agency of plants (cultivated and wild) was more than a mere adaptation to the niches culturally constructed by human populations. Non-humans are active subjects in recovering the functional and structural integrity of agroecosystems after a social or ecological disturbance. All this is part of landscape management based on an “Ecological Diversification Model”, where plant species are adapted to the ecotones and ecological floors of the western Andean foothills, to diversify and increase the availability of food crops that are bioculturally appropriate given the present agrobiodiversity.
Research Progress in Land Consolidation and Rural Revitalization: Current Status, Characteristics, Regional Differences, and Evolution Laws
Authors: Li Shuchang , Song Wei
Published: January 2023

As an invaluable tool to manage land use, land consolidation has been widely used globally, promoting rural revitalization in the context of the current global rural decline. A comprehensive analysis of land consolidation and rural revitalization will help to promote rural development and poverty alleviation and achieve the goals of rural revitalization and regional sustainable development. Based on publications on land consolidation and rural revitalization from 1950 to 2021 in the Web of Science database, this study analyzes the research status, characteristics, regional divides, and evolution laws in land consolidation and rural revitalization using the Bibliometrix and Biblioshiny software packages. The results are as follows: (1) The number of publications per year on land consolidation and rural revitalization increased. According to the publication number, this period can be divided into three stages: the initial stage from 1950 to 2000, the growth stage from 2001 to 2012, and the high-production stage from 2013 to 2021. (2) From 1950 to 2021, 1715 authors published papers on land consolidation and rural revitalization. (3) Respective studies were published by authors in 89 countries or regions, mainly China, the United States, and Poland. Of these, China and the United States played an important role in international cooperation. (4) The keywords in land consolidation and rural revitalization were related to (i) technical efficiency and agricultural production, (ii) the impacts of policy management and systems, and land fragmentation; (iii) the impacts of land consolidation on land use transition against the background of urbanization; (iv) the evaluation of land consolidation. (5) Research on land consolidation has evolved from management over methods and models to land consolidation and regional consolidation.