bluuebunny/crossref_metadata_2025 huggingface dataset:
Mortalité Néonatale dans le Service de Pédiatrie du Centre Hospitalier Universitaire de Kara de 2016 à 2020
Authors: Agbékogni Réné Segbedji Kokou , Ouro-Bagna Tchagbele , Ounoo Elom Takassi , Foli Agbeko , Sollim Myriam Talboussouma , Kadji Kombieni , Yawo Dzayissé Atakouma , Koffi Edem Djadou , Adama Dodji Gbadoe , Komi Deladem Azoumah
Published: April 2022

Objectif : décrire la mortalité néonatale dans le service de pédiatrie du CHU-Kara

Matériel et méthode : il s’agit d’une étude descriptive transversale portant sur les nouveau-nés décédés durant l’hospitalisation du 1er Janvier 2016 au 31 Décembre 2020 au CHU-Kara. Les principaux paramètres étudiés étaient les renseignements généraux, les caractéristiques de la mère, l’histoire et l’évolution de la grossesse, les données liées à l’accouchement, l’état du nouveau-né, la pathologie diagnostiquée et le traitement reçu avant le décès.

Résultats : le taux de mortalité néonatale était de 158,4 ‰ dont 87,8% dans la première semaine de vie. Les facteurs maternels associés aux décès néonataux étaient : l’âge maternel compris entre 18-35 ans, le lieu de provenance et le niveau bas d’instruction. Les facteurs obstétricaux et néonataux associés au décès néonatals étaient : le mauvais suivi de la grossesse, le sexe masculin, l’accouchement par voie basse, l’asphyxie périnatale, la primiparité, la prématurité et la détresse respiratoire néonatale.

Conclusion : la mortalité néonatale constitue un véritable fléau dans notre société. Le renforcement du suivi des femmes enceintes et de la prise en charge précoce du nouveau-né permettra de réduire cette mortalité.

Objective: describe neonatal mortality in the pediatric department of the CHU-Kara.

Material and method: It was a cross-sectional descriptive study on newborns who died during hospitalization from January 1st, 2016 to December 31th, 2020. The main parameters studied were general information, mother’s characteristics of the mother, pregnancy’s history, data related to childbirth, conditions/status of the newborn, diagnosed pathology and treatment received before death.

Results: the neonatal mortality rate was 158.4 ‰ with 87.8% in the first week of life. Maternal associated factors for neonate’s death were: age between 18-35 years, place of origin and low level of education. The obstetric and neonatal factors associated with neonatal death were: weak pregnancy follow-up, male sex, vaginal delivery, perinatal asphyxia, primiparity, prematurity and neonatal respiratory distress.

Conclusion: neonatal mortality is a real scourge in our society. Strengthening the follow-up of pregnant women and early care of the newborn will contribute to reducing this mortality.
Alarming Mortality of Biliary Atresia in Two Senegalese Tertiary Hospitals: A Plea For Early Diagnosis
Authors: Bocar Wellé Ibrahima , Alassane Mbaye Pape , Aby Ndoye Ndeye , Balla Lo Faty , Fatou Seck Ndeye , Gueye Doudou , Ndiaye Dior , Tshibwid A Zeng Florent , Mbaye Aminata , Ndour Oumar , Ngom Gabriel
Published: April 2022

Background: The management of biliary atresia is challenging in low-income countries, with delayed diagnosis and its consequences. We aimed to report its epidemiological, diagnostic, therapeutic aspects and outcomes in Dakar, Senegal.

Methods: We conducted a 5-year retrospective review, which included 16 patients, admitted in the pediatric surgery services of Aristide Le Dantec University Teaching Hospital and Diamniadio Children's Hospital.

Results: The mean age at admission was 105.6 (1 - 420 days), with 10 girls. Cholestatic jaundice was found in all cases, discolored stools in 43.7%, dark urine and hepatomegaly in 31.2%.  All patients had biological cholestasis and cytolysis syndromes. The ultrasound was performed in all patients with a sensitivity of 56.2%.  The mean age at the time of surgery was 145 days (22 – 540 days). The surgical exploration was conducted in 10 cases and found type IV Biliary Atresia in 50%. The Kasai procedure was performed in 4 cases and liver biopsy in 9 cases.  Mortality occurred in 75% (50% post-operatively and 25% pre-operatively). In two cases, the postoperative course was unremarkable with the success of the Kasai Procedure after a 42-months follow-up. Two patients were lost to follow-up.

Conclusion: Biliary atresia still has high mortality in our context. This is mainly due to delayed diagnosis, which is common in our environment. Multidisciplinary assessment of persistent neonatal jaundice is crucial to reduce biliary atresia-related mortality
Especialistas em direito e regimes autoritários no Brasil
Authors: Wohnrath Vinicius
Published: April 2022

A ditadura militar instalada no Brasil em 1964 investiu na construção de bases jurídicas para garantir uma aparente legalidade ao golpe de Estado e às ações dele decorrentes. Para tanto, diferentes especialistas colocaram seus conhecimentos a serviço do Estado de exceção. Originado de investigação empírica, a partir de análises de trajetórias este artigo examina os capitais sócio-profissionais dos juristas indicados para comporem a Comissão Especial de 1966. Habilitados para pensar uma nova Constituição para o País, o trabalho destes agentes do direito não prosperou. Todavia, suas afinadas relações com a cúpula do Poder Executivo, associadas com suas origens sociais, formações acadêmicas, carreiras públicas e prestígios políticos, permitiram compreender as características das elites civis que apoiaram, a partir de suas expertises, aquele regime autoritário.
Estrategia didáctica para desarrollar las competencias digitales en los estudiantes del VII Ciclo de la escuela profesional de administración de empresas en una universidad nacional de Apurímac
Authors:   ,   Universidad San Ignacio de Loyola, Guillen Cuba Sandy
Published: April 2022

La presente investigación propone un modelo de estrategia didáctica orientada a determinar la estrategia didáctica para desarrollar las competencias digitales en los estudiantes del VII ciclo de la Escuela Profesional de Administración de Empresas en una universidad nacional de Apurímac. La investigación está enmarcada bajo el paradigma sociocrítico, enfoque cualitativo, de tipo aplicada educacional y un diseño no experimental. Las técnicas para la recolección de datos son la encuesta y la entrevista, cuyos instrumentos son tres cuestionarios y dos guías de entrevistas semiestructuradas. El diagnóstico evidencia que la subcategoría competencia multimedia y subcategoría competencia comunicacional son las menos desarrolladas en las competencias digitales. Asimismo, existen oportunidades de mejora en relación con estrategia didáctica, como la necesidad de utilizar estrategias de aprendizaje en entornos virtuales y presenciales, herramientas digitales y TIC, además de utilizar gamificación durante el proceso de enseñanza y aprendizaje. A partir del diagnóstico, se plantea una estrategia didáctica fundamentada en el enfoque del conocimiento significativo planteado por Ausubel citado por (Tobón et al., 2010) en aspectos básicos tales como estrategias de motivación, gamificación y metacognición (Herrera, 2015). De la misma forma, la estrategia didáctica está diseñada teniendo en cuenta el método de aprendizaje basado en problemas. Finalmente se concluye que esta estrategia didáctica representa un aporte práctico hacia la institución mencionada y garantiza que se promueva las competencias digitales en los estudiantes de VII ciclo.
Technological resources in bilingual education for deaf students
Authors: Sena Lílian de Sousa , Serra Ilka Márcia Ribeiro de Souza , Schlemmer Eliane
Published: April 2022

Digital technologies present many possibilities to enhance the teaching and learning processes of deaf and hearing students. An example of this are the technological didactic games, which can contribute to learning and digital and social inclusion. Using strategies that promote the inclusion of deaf students is currently a latent need.  Thus, this paper aims to study the use of playful resources structured with the Power Point tool in the process of acquisition of Portuguese language in a bilingual proposal with sign language. This study aims to analyze the contribution of technological didactic games in the process of acquisition of Portuguese Language, by high school students, in a classroom context composed of deaf and hearing students, in a school located in the city of Timon, in the state of Maranhão. It is a field research, of exploratory and qualitative nature, which also investigates the representation of deaf culture in the didactic games used, and the contribution of technological resources in educational contexts that do not have access to the internet. To achieve the objectives, in addition to bibliographic references, it was made observation of the classes with the use of games and application of semi-open questionnaire for analysis. The results show that digital games promote engagement and motivation for learning, and that playfulness provides the creation of a more empathetic and inclusive environment.
Managing the pedagogical culture of university teachers in the context of the impact of COVID-19
Authors: Pakhomova Tetyana , Matvieienko Iryna , Khavarivska Halyna , Shulha Tetiana
Published: April 2022

The main purpose of the article is to study the features of the pedagogical culture of university teachers in the context of the impact of COVID-19. New trends in education that emerged at the turn of the second and third millennia, the emergence of new paradigms of education, a new system of social values and goals of education, its dialogue with human culture as its creator and subject capable of cultural self-education, stimulated a special interest in the study of the phenomenon of "pedagogical culture" and its components. The events taking place in the world as a result of the spread of the coronavirus infection COVID-19 refer to a global emergency of a nature. Of course, in these forced conditions, it is difficult for teachers to simultaneously master new methods and tools of distance learning, develop methodological support for the disciplines taught, or transform it into a digital form and immediately introduce it into the educational process. As a result of the study, the main trends in the development of modern pedagogical culture of university teachers in the context of the impact of COVID-19 were identified.
Perspektif Fishbein Model dalam Pengelolaan Pesan Persuasif Petani Agribisnis Pepaya Calina Melalui Media Sosial
Authors: Djaya Tika Ristia
Published: April 2022

Social media as a means to obtain information and knowledge and build relationships / relational that has its own allure because of low cost, can reach space and time. Thus the message will easily reach the communicant, so that feedback can be obtained immediately. In accordance with the communication function one of which is to persuade the communicant to support the message conveyed by the communicator. So that the communicant acts like a message delivered by the communicator. In this case the communicator is a calina papaya farmer and the communicant is a farmer in general in Magelang, Central Java. But it does not rule out the possibility that farmers in general can become communicators when the conversation occurs. This study aims to determine the farmers in Magelang, Central Java in getting information on calina papaya agribusiness from the perspective of the fishbein model. The research method used is a qualitative method with an explorative study approach. The results showed farmers in the area of Magelang had been inspired and obsessed with social media messages about the agribusiness of calina papaya as a planting option by considering yields. Thus it means that calina papaya farmers have managed the message as in the perspective of the fishbein model regarding the calina papaya agribusiness through various social media. This study concluded that: (1). Persuasive messages are managed by showing visual evidence, delivery methods, systematic / ways to develop content, so that the message is organized and can be trusted. (2). Publish strong arguments using language that is easy to understand and focuses more on experience. (3). Practice involvement. This involvement can be an educational practice as well as being able to interact among the farmers of  calina papaya.
Pengaruh Terpaan Iklan Marketplace, Akses Aplikasi, dan Minat Membeli Pada Mahasiswa
Authors: Norhabiba Fitri
Published: April 2022

As a new media, internet not only as production tools but also distributed message. Internet has a function like traditional media, internet as a storage message. Internet has many easier tools and become many application to be access many times. Consumer behavior has changed from traditional to online.

This research tried to examine aspect of elaboration likelihood model and advertising exposure and connected to consumer behavior on youth, especially students in the big city.

This research took place di University of 17 August Surabaya, located in the central city of Surabaya, and could be represent students. The population is students of Untag Surabaya 13849. The sampel is 160, based n slovin formula and used systematic random sampling. The type of the research is quantitative descriptive, the data used to generalize youth in the city.

The result show that there is a influence of marketplace’s advertising exposure, application access to buying interest toward student with linear regression. The influence of marketplace’s advertising exposure, application access to buying interest is 41,9%. R2=0,419,6 β=0,408;p<0,01.

 

Keywords: advertising exposure, buying interest, elaboration likelihood model

 
Strategi Promosi lazada.co.id dalam Menarik Minat Belanja Online Mahasiswa Public Relations Universitas Kristen Satya Wacana
Authors: Septiani Dian , Zanel Von
Published: April 2022

Promotion strategy is the company's activity to drive sales by directing convincing communications to buyers. In attracting shopping interests, some of the biggest online shops such as Lazada.co.id also use promotional strategies to attract shopping interests from prospective customers, especially those among students. The purpose of this research is to find out and describe how Lazada.co.id' promotion strategy attracts online SWCU public relations student shopping interests. The research method used is descriptive qualitative, where the subject of this study is a public relations student for the class of 2017-2019 and the object of research is the promotion strategy lazada.co.id in attracting online shopping interests of public relations students. Data collection techniques are by interviewing public relations students for the 2017-2019 class year, observing and also documenting from the Lazada.co.id website, and to strengthen the results of the interview the researchers also distributed questionnaires of 60 respondents. The results of research conducted based on the results of the interview also by distributing questionnaires, the results obtained that the promotion strategy carried out is a mix promotion and online shopping interest of students is influenced by several promotional strategies including advertising promotion strategies, public relations, sales promotion, direct marketing, while for promotion strategies that do not affect student online shopping interest is selling personnel.
Konstruksi Kuasa Presiden Jokowi dalam Pidato “Indonesia Darurat Corona”
Authors: Robin Patricia , Priscila Gabriela
Published: April 2022

Wabah Covid-19 merupakan titik balik kehidupan manusia. Segi kehidupan pribadi dan sosial berubah, waktu bekerja menjadi lama, dan pemilihan penggunaan media menjadi lebih terpola. Hal ini memunculkan kebijakan dan keputusan baru dari Pemerintah. Penelitian ini menggunakan Analisis Wacana Kritis Norman Fairclough untuk membongkar teks pidato Presiden Joko Widodo yang lekat dengan unsur kekuasaan dalam lingkup massif dan kooperatif. Adapun pembahasan ini melingkupi segi wacana mikrostruktur membahas representasi, hubungan, dan identitas; analisis wacana mesostruktur, yang erat dengan produksi, konsumsi, dan reproduksi teks kekuasaan yang tidak seimbang; dilanjutkan dengan analisis wacana makrostruktur (sosiokultural) yang melihat dari aspek situasional, kelembagaan, dan sosial. Presiden Jokowi menjawab keresahan masyarakat mengenai penanganan wabah dan perekonomian, serta menunjukkan bahwa pemerintah telah melakukan usaha-usaha dan menyiapkan skenario-skenario untuk segala kemungkinan. Melalui pidato ini, Presiden Jokowi sekaligus merespon asumsi kepemimpinannya yang kurang tegas dan banyaknya ketidaksesuaian antara pusat dan daerah dengan menegaskan kebijakan mengenai PSBB. Perhatian utama peneliti adalah pada pemilihan kata yang digunakan oleh Presiden Jokowi dalam penyampaian Pidato. Menjadi perhatian ketika sebuah keputusan yang ditetapkan oleh pemerintahan seakan menjadi pertunjukkan satu orang semata.

 

Keywords: Norman Fairclough; Pidato Presiden Jokowi; Kekuasaan Foucault; PSBB
Bersama Indonesia Power, Kembangkan Potensi Pariwisata Jawa Tengah untuk Pariwisata yang Berdikari Pasca Pandemi
Authors: Mardhiyani Nur Laili , Kinanthi Laksmi , Hidayat Satria Nur , Bertrand B.T Louis , Sofia Dina , Purbasiwi K Sekar , Shifananda V.P Jeva Shifananda V.P
Published: April 2022

Glagah Wangi Beach or Instanbul Demak is a beach in the coastal area of Demak Regency which offers the beauty of Mangrove forest tourism. Glagah Wangi Beach is one of the tours that has become an icon of Demak Regency which is also included in the 10 nominations for new tourist destinations held by the Anugerah Pesona Indonesia (API) 2020. Glagah Wangi Beach itself is located in Tambak Bulusan Village, Dukuh Bongsari, Kec. Karang Tengah with the distance to the district center is approximately 20 km or 1 hour away by motorbike or car. This service aims to increase the potential of regional tourism to become the choice of tourist attractions in Central Java and Indonesia, increase the income of the surrounding community by developing tourism activities based on training and education on good tourism management in accordance with ISO standards, increasing brand awareness and brand reputation of PT. Indonesia Power; get PR Value in the form of news in the mass media (print, digital and electronic).

 

Keywords: Glagah Wangi Beach; Istanbul Demak; Tourism; Mangrove Forest
Fenomena Cyberbullying pada Mahasiswa di Jakarta Selatan
Authors: Hanika Ita Musfirowati , Witjaksono Alyza Asha , Pratiwi Stefani Ira
Published: April 2022

Perundungan siber merupakan bentuk tindakan perundungan dalam bentuk pelecehan, ancaman, intimidasi hingga kekerasan melalui berbagai teknologi digital yang dapat mempengaruhi keselamatan korban. Di Indonesia, terdapat 25 kasus cyberbullying yang dilaporkan setiap hari oleh remaja sebagai pengguna aktif Internet dan jumlahnya semakin meningkat dari tahun ke tahun. Selain dipicu oleh tingginya penggunaan Internet, rendahnya literasi media digital juga menjadi faktor pendorong maraknya cyberbullying pada remaja khususnya mahasiswa. Hasil penelitian menunjukkan bahwa 25,9 persen remaja pernah menjadi korban cyberbullying dan 13 persen responden pernah menjadi pelaku cyberbullying. Umumnya korban mengalami tindak cyberbullying yaitu 58,5 persen menerima makian melalui media sosial. Tindakan cyberbullying ini dialami korban melalui media sosial, salah satunya Instagram dan Twitter. Selain itu ditemukan bahwa tujuan pelaku dalam melakukan tindakan perundungan siber itu hanya sekadar iseng saja. Penelitian ini bertujuan untuk mengetahui fenomena cyberbullying yang terjadi pada mahasiswa di Jakarta Selatan agar dapat ditemukannya cara dalam menekan tingkat perundungan siber yang terjadi.
Menjaga Stabilitas Perusahaan Bandeng Juwana Elrina melalui Perencanaan Program Community Relations Petani Tambak Wonoagung
Authors: Mardhiyani Nur Laili , Wulandari Arum Desti , Hanifa Millati , Ayunda Tsalsa Amilia , Krisnawan Elza Orvint
Published: April 2022

The increasing number and development of companies and UMKM resulted in intense competition in the business world. To obtain support from various parties to maintain the survival of the company or UMKM, it is necessary to have Community Relations activities to maintain the stability of the activities of the company or UMKM. These activities are not limited to just looking for profit but also pay attention to the benefit of the surroundings or the target of Community Relations itself.

This research is aimed at Milkfish Juwana Elrina with several proposed activity programs for the target, namely pond farmers in Wonoagung Village, Demak Regency with several programs such as training, empowerment, and the provision of other facilities.

The purpose of this research is to create a relationship with the target audience, provide a new product for Milkfish Juwana Elrina and improve the welfare of the people of Wonoagung Village, Demak Regency.

This study uses a descriptive qualitative research method. Descriptive research is to describes the quality of a symptom to make the reader know what is happening in the related research.

 
Harapan dan Pelanggaran Komunikasi Interpersonal dalam Layanan GrabBike dari Grab di Yogyakarta
Authors: Airnugraha Emmanuelle Poendradhewa Indra , Habibi Gilang
Published: April 2022

One of the application-based motorcycle taxis available in Indonesia is Grab. Using the 'expectancy violation theory', this qualitative research with in-depth interview method aims to find out the hidden meaning, to understand social interactions related to satisfaction in interpersonal communication in GrabBike service from Grab in Yogyakarta between the drivers and the customers. The results of the study indicate that communication is needed between drivers and customers to be able to find out the position of both. Interpersonal communication is a communication process between the communicant and the communicator which is characterized by the realization of mutual understanding, pleasure, mutual influence, good social relations, as well as real action as feedback. communication is expected to reduce the adverse effects that arise on the group related to job burnout
THE ISSUE OF PROFESSIONAL COMPETENCE FORMATION IN FUTURE CHEMICAL TECHNOLOGY BACHELORS AT HIGHER EDUCATION INSTITUTIONS OF THE USA AND UKRAINE
Authors: Gren Larissa , Kurbanova Khalida
Published: April 2022

the article defines the ways of chemical engineering formation and development in the USA; the general tendencies in development of chemical technologies education at higher education institutions of the USA and Ukraine have been outlined. It has been established that both countries have experienced the same difficulties in the issues concerning formation of professional competence in future chemical technology bachelors at higher education institutions, namely the lack of professional skills (communicative, creative, critical and ethical thinking, teamwork, and leadership skills), the lack of skills in interdisciplinary problem solving, the absence of independent learning skills, as well as a smaller share of the practical component in the university training compared with the theoretical one. General tendencies in successful solving of the issues regarding professional competence in future chemical technology bachelors have been considered.
THE APPLICATION OF THE RASCH MODEL TO DEVELOP TWO-TIER MULTIPLE CHOICE HIGHER ORDER THINKING SKILL TEST ON MOTION AND FORCE
Authors: Swastika Rhea Zivanka  , Silitonga Haratua Tiur Maria , Hamdani
Published: April 2022

In Indonesia, students' higher order thinking skill is considered low and students still struggle to solve HOTS problems. One of the reasons is that students are unfamiliar with HOTS questions. This research aims to produce two – tier multiple choice test to measure students' higher order thinking skill on motion and force. The method used in this research is 4D by Thiagarajan. The test developed was validated by experts and was tested on 250 8th grade students in Pontianak. Analysis of the test used the Rasch Model to determine item fit, reliability, and difficulty levels using Winstep. Based on the qualitative and quantitative analysis, the test developed is feasible to measure students' higher order thinking skill with the content validity value score 0,84 and construct validity explained by the test 64,71%. The item reliability is excellent with the score of 0,94 but students have low consistency in answering the test. The test developed consist of 2 very difficult items, 6 difficult items, 5 easy items, and 2 very easy items.
Review of: Michael J. B. Allen, Studies in the Platonism of Marsilio Ficino and Giovanni Pico, Routledge, London–New York 2017 (Variorum Collected Studies Series,1063). XIII + 348 pp., ISBN: 9781472448385.
Authors: Monfasani John
Published: April 2022

Review of:

Michael J. B. Allen, Studies in the Platonism of Marsilio Ficino and Giovanni Pico, Routledge, London–New York 2017 (Variorum Collected Studies Series,1063). XIII + 348 pp., ISBN: 9781472448385.
Scientific Perspectives on Psalm 148 in Medieval Jewish Exegesis
Authors: Gómez Aranda Mariano
Published: April 2022

Psalm 148 is a hymn inviting all beings in the celestial world and the earthly world to praise God. Even though the Psalm seems simple and easy to understand, two questions have been raised in the history of the exegesis of this Psalm: why are these specific creatures and no others mentioned in the Psalm?, and why are they placed in this particular order? In Ancient Judaism no much attention was given to the explanation of this Psalm from a scientific perspective; however, in the thirteenth century, in the context of the reception of Aristotelianism in southern France, important exegetes such as David Qimhi and Menahem ha-Meiri interpreted this Psalm to the light of Aristotelian cosmology, and more especifically in consonance with scientific ideas exposed in Aristole’s Meteorology. Abraham ibn Ezra was the first Jewish exegete who wrote a systematic commentary on Psalm 148 to demonstrate that the biblical text describes the structure, composition and laws of the Universe according to Aristotelian principles. Ibn Ezra’s scientific comments on this Psalm were the starting point for the future scientific analysis of later exegetes in southern France, such as David Qimhi and Menahem ha-Meiri. It is the purpose of this article to analyze how Psalm 148 has been interpreted by these three Jewish exegetes from a scientific perspective and to prove how later exegetes explained, developed or even refuted the scientific interpretations of their predecessors. It also examines the sources that Ibn Ezra may have used to know Aristotle’s ideas.
The Greek Fragments of the Works of Māšāʾallāh ibn Aṯarī
Authors: Farina Luca
Published: April 2022

This article provides an overview of the Greek mentions of the Arabic astrologers Māšāʾallāh ibn Aṯarī al-Baṣrī and Abū Maʿšar al-Balḫī, together with the edition of the Greek fragments explicitly attributed to Māšāʾallāh, based on all their witnesses. Moreover, a general introduction to the Greek tradition of the two astrologers and a discussion of their mentions in the manuscript Vatican City, Biblioteca Apostolica Vaticana, Vat. gr. 1056 are supplied.
Out of Maragha: Observations, Teachings, and Translations
Authors: Roughan Christine
Published: April 2022

This paper examines the context for the Greek translations and adaptions of Islamic astronomical works which came out of Maragha and Tabriz at the end of the thirteenth century. It discusses the observation programs and the teaching activities of astronomers at the Maragha Observatory in order to shed light on the relation of the translated texts to the intellectual activities at the observatory and to the broader picture of education in the astral sciences in these two cities. The paper argues that astronomical education in these centers drew from a combination of more established teaching texts and of newer works by the astronomers and teachers at the observatory, and that the selection of sources that received translations and adaptions in Greek was motivated by the particular needs of the Byzantine student or students in question.
Review of: Cecilia Muratori, Renaissance Vegetarianism: The Philosophical Afterlives of Porphyry’s ‘On Abstinence’, Legenda, Cambridge 2020 (Italian Perspectives, 46), 276 pp., ISBN 9781781883389.
Authors: Durán Mañas Monica
Published: April 2022

Review of:

Cecilia Muratori, Renaissance Vegetarianism: The Philosophical Afterlives of Porphyry’s ‘On Abstinence’, Legenda, Cambridge 2020 (Italian Perspectives, 46), 276 pp., ISBN 9781781883389.
Review of: Florian Hamann, Das Renaissanceabenteuer, Muslime zu bekehren. Ein philosophischer Feldzug, Wissenschaftliche Buchgesellschaft, Darmstadt 2021, 283 pp., ISBN: 9783534404599.
Authors: Imbach Ruedi
Published: April 2022

Review of:

Florian Hamann, Das Renaissanceabenteuer, Muslime zu bekehren. Ein philosophischer Feldzug, Wissenschaftliche Buchgesellschaft, Darmstadt 2021, 283 pp., ISBN: 9783534404599.
Review of: Massimiliano Traversino Di Cristo (ed.), Giordano Bruno: Law, Philosophy, and Theology in the Early Modern Era, Classiques Garnier, Paris 2021 (Works from the Centre for Further Study of the Renaissance, 7), 478 pp., ISBN: 9782406104469.
Authors: Brotto Luisa
Published: April 2022

Review of:

Massimiliano Traversino Di Cristo (ed.), Giordano Bruno: Law, Philosophy, and Theology in the Early Modern Era, Classiques Garnier, Paris 2021 (Works from the Centre for Further Study of the Renaissance, 7), 478 pp., ISBN: 9782406104469.
Review of: Laura Stagno, Borja Franco Llopis (eds.), Lepanto and Beyond. Images of Religious Alterity from Genoa and the Christian Mediterranean, Leuven University Press, Leuven 2021, 324 pp., ISBN: 9462702640.
Authors: Zardin Danilo
Published: April 2022

Review of:

Review of: Laura Stagno, Borja Franco Llopis (eds.), Lepanto and Beyond. Images of Religious Alterity from Genoa and the Christian Mediterranean, Leuven University Press, Leuven 2021, 324 pp., ISBN: 9462702640.
Review of: Bente Maegaard, Riccardo Pozzo, Alberto Melloni, Matthew Woollard (eds.), Stay Tuned to the Future: Impact of the Research Infrastructures for Social Sciences and Humanities, Leo S. Olschki, Firenze 2019, XXXVI + 190 pp., ISBN: 9788822266439.
Authors: Fantoli Margherita
Published: April 2022

Review of:

Bente Maegaard, Riccardo Pozzo, Alberto Melloni, Matthew Woollard (eds.), Stay Tuned to the Future: Impact of the Research Infrastructures for Social Sciences and Humanities, Leo S. Olschki, Firenze 2019 (Lessico intellettuale europeo, 128), XXXVI + 190 pp., ISBN: 9788822266439.
In memoriam Josef van Ess (18.IV.1934–20.XI.2021)
Authors: Aguade Jordi
Published: April 2022

In memoriam

Josef van Ess

(18.IV.1934–20.XI.2021)
Review of: Valery Rees, Anna Corrias, Francesca M. Crasta, Laura Follesa, Guido Giglioni (eds.), Platonism, Ficino to Foucault, Leiden–Boston, Brill 2021 (Brill’s Studies in Intellectual History, 320), 357 pp., ISBN: 9789004358935.
Authors: Steiris Georgios
Published: April 2022

Review of:

Valery Rees, Anna Corrias, Francesca M. Crasta, Laura Follesa, Guido Giglioni (eds.), Platonism, Ficino to Foucault, Leiden–Boston, Brill 2021 (Brill’s Studies in Intellectual History, 320), 357 pp., ISBN: 9789004358935.
Exploring Robust Architectures for Deep Artificial Neural Networks
Authors: Waqas Asim , Rasool Ghulam , Farooq Hamza , Bouaynaya Nidhal
Published: April 2022

The architectures of deep artificial neural networks (DANNs) are routinelystudied to improve their predictive performance. However, the relationshipbetween the architecture of a DANN and its robustness to noiseand adversarial attacks is less explored. We investigate how the robustnessof DANNs relates to their underlying graph architectures or structures.This study: (1) starts by exploring the design space of architecturesof DANNs using graph-theoretic robustness measures; (2) transforms thegraphs to DANN architectures to train/validate/test on various imageclassification tasks; (3) explores the relationship between the robustnessof trained DANNs against noise and adversarial attacks and the robustnessof their underlying architectures estimated via graph-theoreticmeasures. We show that the topological entropy and Olivier-Ricci curvatureof the underlying graphs can quantify the robustness performanceof DANNs. The said relationship is stronger for complex tasks and largeDANNs. Our work will allow autoML and neural architecture searchcommunity to explore design spaces of robust and accurate DANNs.
Increased expression of syncytin-1 in skeletal muscle of humans with increased body mass index
Authors: Ravichandran Jayachandran , Roust Lori R , Katsanos Christos
Published: April 2022

Obesity negatively impacts skeletal muscle protein metabolism, and also impairs skeletal muscle maintenance and regeneration. We analyzed muscle biopsy samples from humans with increased body mass index (BMI) (i.e. > 30 kg/m2) and controls (i.e., BMI < 25 kg/m2) for expression of syncytin-1, a fusogenic protein regulating skeletal muscle regeneration. When compared to controls, humans with increased BMI and concomitant reduction in muscle protein synthesis had higher expression of syncytin-1 in skeletal muscle (P < 0.05). Across human subjects, muscle protein synthesis correlated inversely (r = -0.51; P = 0.03) with syncytin-1 expression in muscle. Using a C2C12 cell line we found that expression of syncytin-A (i.e, corresponding protein in murine tissue) is increased by insulin, and that this response is impaired in the presence of fatty acids, whose metabolism is altered within the metabolic environment induced by increased BMI. In C2C12 cells, the response of the protein 4E-BP1, which signals increase in protein synthesis in muscle, resembled that of syncytin-A. These findings provide novel insights into the expression of syncytin-1 in skeletal muscle of humans with increased BMI, as well as its basic regulation by insulin and fatty acids in muscle. The findings signify the need for further research into the regulation of syncytin-1 in skeletal muscle of humans with increased BMI, as well as its biological implications for altering muscle protein metabolism and regeneration.
Trade openness and real effective exchange rate volatility: The case of Vietnam
Authors: Thi Kim Lien Nguyen , Thi Doan Thu-Trang , Ngoc Bui Toan
Published: April 2022

2004–2020. The study was conducted in the context that Vietnam’s trade openness is increasing, causing significant challenges in macro management, including exchange rate management. The authors use vector autoregression model and Granger causality test to test this relationship. The study used a vector autoregression model and Granger causality test to investigate the causal relationship between trade openness and real effective exchange rate volatility in Vietnam over the period 2004–2020. The study was conducted in the context of Vietnam’s trade openness index rising, causing significant challenges in macro management, including exchange rate management. The study takes a new approach (i) using Vietnam’s real effective exchange rate relative to 143 trading partners; and (ii) examining the impact of economic growth on trade openness and exchange rate volatility. The research results indicate that trade openness has a two-way Granger causality with effective real exchange rate volatility in Vietnam at the 1% significance level. Specifically, the effect of trade openness on real exchange rate volatility is positive at a 1-period lag and 4-period lag. Meanwhile, real exchange rate fluctuations have a negative effect on trade openness with a 1-period lag. At the same time, the study also finds that increased economic growth reduces real effective exchange rate volatility and increases Vietnam’s trade openness. On that basis, the study proposes implications for the management of trade openness and exchange rate management in the current Vietnamese context.
Mediation role of management commitment on improving fraud prevention in primary healthcare: Empirical evidence from Indonesia
Authors: Lastri Surna , Fahlevi Heru , Diantimala Yossi , Ridwan
Published: April 2022

Fraud in primary healthcare (PHC) is an important and relevant topic to study because of its impact on the state in terms of financial losses and a decrease in the quality of PHC. This study is also relevant because previous studies that formulate a model and measure fraud prevention comprehensively are still limited. It aims to examine the mediating role of management commitment on the effect of apparatus competence and internal control system on fraud prevention. The sample comprises 78 PHCs and 234 senior managers as respondents in Aceh Province, Indonesia. Data for this study were collected using questionnaires from March to July 2021. Structural equation modeling was used to examine a causal relationship between the variables. The result shows that apparatus competence and internal control system positively affect management commitment and fraud prevention with p-value 0.000 (p > 0.01). Likewise, management commitment has a positive effect on fraud prevention with p-value 0.000 (p > 0.01). The findings show that management commitment mediates the relationship between the internal control system and fraud prevention. At the same time, the apparatus competence does not directly affect fraud prevention. The practical significance of this study is the importance of implementing an effective internal control system and high management commitment as a mediating variable for fraud prevention.
AcknowledgmentsThe authors are very thankful to the University of Muhammadiyah Aceh, which has supported this study, and all those who have contributed to this investigation.
Milli Eğitim Bakanlığı Ortaöğretim Kurumlarına Okul Yöneticisi Seçme ve Görevlendirme Model Önerisi
Authors: Demirer Mustafa , Ergezen Mehmet Duran
Published: April 2022

Araştırma, 5 Şubat 2021 tarihinde resmî gazetede yayınlanarak yürürlüğe giren Millî Eğitim Bakanlığına bağlı eğitim kurumlarına yönetici seçme ve görevlendirme yönetmeliğini tartışmaya açmayı amaçlamıştır. Araştırma ile Millî Eğitim Bakanlığına bağlı ortaöğretim kurumlarına (ortaokul, lise) yönetici seçme ve görevlendirme yöntemiyle ilgili mevcut durum tespit edilip, veriler doğrultusunda bir model önerisi sunulmuştur. Nicel araştırma yöntemlerinden betimsel tarama ve anket uygulaması modelinde tasarlanan araştırmada, random usulüyle seçilen 351 katılımcı araştırma örneklemine alınmıştır. Araştırmanın verileri İstanbul ili Bahçelievler, Esenler, Güngören ve Şişli’de bulunan ortaöğretim kurumları eğitim yöneticisi, okul yöneticisi ve öğretmenlerden elde edilmiştir. Çalışmada katılımcıların cinsiyetlerinin yöneticilik yapma tutumu ve yönetici becerileri ve yetkinlik düzeyleri üzerinde etkili olduğu tespit edilmiştir. Kadın katılımcıların yönetici olmak için bireylerin daha üst düzey beceri ve yetkilere sahip olması gerektiğini düşünmektedir. Mesleki kıdem düzeylerine göre yöneticilik yapma tutumu, yönetici atama kriteri, yönetici becerileri ve yetkinlik düzeylerinin farklılık gösterdiği saptanmıştır. Araştırma mesleki kıdemin artmasının yöneticilik yapma isteğini azalttığını ortaya koymuştur. Çalışma katılımcıların yöneticilik yapma tutumları arttığında, yönetici beceri ve yeterlilik kriterlerinin de artış göstereceğini ortaya koymuştur. Araştırma ile yönetici adaylarının iletişim becerilerinin ölçüleceği mülakat sınavlarının gerekli olduğu ve niteliğinin arttırılması gerektiği sonucuna varılmıştır. Çalışma sonuçlarından hareketle politika belirleyiciler için uygulamaya dönük bir model önerisi sunulmuştur.
Beneficial Effects of Carvacrol on In Vitro Models of Metabolically-Associated Liver Steatosis and Endothelial Dysfunction: A Role for Fatty Acids in Interfering with Carvacrol Binding to Serum Albumin
Authors: Khalil Mohamad , Serale Nadia , Diab Farah , Baldini Francesca , Portincasa Piero , Lupidi Giulio , Vergani Laura
Published: April 2022

Background:

Carvacrol, a plant phenolic monoterpene, is largely employed as
food additive and phytochemical.

Objective:

We aimed to assess the lipid lowering and protective effects of carvacrol in
vitro using cellular models of hepatic steatosis and endothelial dysfunction. We also investigated
if and how the binding of carvacrol to albumin, the physiological transporter
for small compounds in the blood, might be altered by the presence of high levels of fatty
acids (FAs).

Methods:

Hepatic FaO cells treated with exogenous FAs mimic hepatosteatosis; endothelial
HECV cells exposed to hydrogen peroxide are a model of endothelial dysfunction. In
these models, we measured spectrophotometrically lipid accumulation and release,
lipoperoxidation, free radical production, and nitric oxide release before and after treatment
with carvacrol. The carvacrol binding to albumin in the presence or absence of high
levels of FAs was assessed by absorption and emission spectroscopies.

Results:

Carvacrol counteracted lipid accumulation and oxidative stress in hepatocytes
and protected endothelial cells from oxidative stress and dysfunction. Moreover, high levels
of FAs reduced the binding of carvacrol to albumin.

Conclusion:

The results suggest the good potential of carvacrol in ameliorating dysfunction
of hepatic and endothelial cells in vitro. High levels of circulating FAs might compete
with carvacrol for binding to albumin thus influencing its transport and bio-distribution.
Selective Delivery of Clinically Approved Tubulin Binding Agents through Covalent Conjugation to an Active Targeting Moiety
Authors: Collyer Samuel E. , Stack Gary D. , Walsh John J.
Published: April 2022

The efficacy and tolerability of tubulin binding agents are hampered by their
low specificity for cancer cells like most clinically used anticancer agents. To improve
specificity, tubulin binding agents have been covalently conjugated to agents that target
cancer cells to give actively targeted drug conjugates. These conjugates are designed to
increase uptake of the drug by cancer cells while having limited uptake by normal cells,
thereby improving efficacy and tolerability. Approaches used include an attachment to
small molecules, polysaccharides, peptides, proteins, and antibodies that exploit the overexpression
of receptors for these substances. Antibody targeted strategies have been the
most successful to date, with six such examples having gained clinical approval. Many
other conjugate types, especially those targeting the folate receptor, have shown promising
efficacy and toxicity profiles in pre-clinical models and in early-stage clinical
studies. Presented herein is a discussion of the success or otherwise of the recent strategies
used to form these actively targeted conjugates.
Insights into Interactions of Human Cytochrome P450 17A1: A Review
Authors: Singh Himanshu , Kumar Rajnish , Mazumder Avijit , Salahuddin  , Mazumder Rupa , Abdullah Mohd. Mustaqeem
Published: April 2022

Cytochrome P450s are a widespread and vast superfamily of hemeprotein monooxygenases that metabolize
physiologically essential chemicals necessary for most species' survival, ranging from protists to plants to humans.
They catalyze the synthesis of steroid hormones, cholesterol, bile acids, and arachidonate metabolites and the
degradation of endogenous compounds, such as steroids, fatty acids, and other catabolizing compounds as an energy
source and detoxifying xenobiotics, such as drugs, procarcinogens, and carcinogens. The human CYP17A1 is one of
the cytochrome P450 genes located at the 10q chromosome. The gene expression occurs in the adrenals and gonads,
with minor amounts in the brain, placenta, and heart. This P450c17 cytochrome gene is a critical steroidogenesis
regulator which performs two distinct activities: 17 alpha-hydroxylase activity (converting pregnenolone to 17-
hydroxypregnenolone and progesterone to 17-hydroxyprogesterone; these precursors are further processed to provide
glucocorticoids and sex hormones) and 17, 20-lyase activity (which converts 17-hydroxypregnenolone to DHEA).
Dozens of mutations within CYP17A1 are found to cause 17-alpha-hydroxylase and 17, 20-lyase deficiency. This
condition affects the function of certain hormone-producing glands, resulting in high blood pressure levels (hypertension),
abnormal sexual development, and other deficiency diseases. This review highlights the changes in CYP17A1
associated with gene-gene interaction, drug-gene interaction, chemical-gene interaction, and its biochemical reactions;
they have some insights to correlate with the fascinating functional characteristics of this human steroidogenic
gene. The findings of our theoretical results will be helpful to further the design of specific inhibitors of CYP17A1.
Draft Genome Sequence of the Earthworm Eudrilus eugeniae
Authors: Sivasubramaniam Sudhakar , Arumugaperumal Arun , Sudalaimani Dinesh Kumar , Arumugaswami Vaithilingaraja
Published: April 2022

Background:

Earthworms are annelids. They play a major role in agriculture and soil fertility. Vermicompost is the best organic manure for plant crops. Eudrilus eugeniae is an earthworm well
suited for efficient vermicompost production. The worm is also used to study the cell and molecular
biology of regeneration, molecular toxicology, developmental biology, etc., because of its abilities like
high growth rate, rapid reproduction, tolerability toward wide temperature range, and less cost of
maintenance.

Objective:

The whole genome has been revealed only for Eisenia andrei and Eisenia fetida.

Methods:

In the present work, we sequenced the genome of E. eugeniae using the Illumina platform
and generated 160,684,383 paired-end reads

Results:

The reads were assembled into a draft genome of size 488 Mb with 743,870 contigs and successfully annotated 24,599 genes. Further, 208 stem cell-specific genes and 3,432 non-coding genes
were identified.
Vitamin D and its Possible Relationship to Neuroprotection in COVID-19:
Evidence in the Literature
Authors: Quintero-Fabián Saray , Bandala Cindy , Pichardo-Macías Luz Adriana , Contreras-García Itzel Jatziri , Gómez-Manzo Saúl , Hernández-Ochoa Beatriz , Martínez-Orozco José Arturo , Ignacio- Mejía Iván , Cárdenas-Rodríguez Noemí
Published: April 2022

Vitamin D is a hormone involved in the regulation of important biological processes such
as signal transduction, immune response, metabolic regulation and also in the nervous and vascular
systems. To date, coronavirus disease 2019 (COVID-19) infection does not have a specific treatment.
However, various drugs have been proposed, including those that attenuate the intense inflammatory
response, and recently, the use of vitamin D, in clinical trials, as part of the treatment of
COVID-19 has provided promising results. It has been observed in some clinical studies that the use
of cholecalciferol (vitamin D3) and its two metabolites the circulating form, calcidiol or calcifediol
(25-hydroxycalciferol, 25-(OH)-D), and the active form, calcitriol (1,25-(OH)2-D), in different doses,
improve the clinical manifestations, prognosis, and survival of patients infected with COVID-19
probably because of its anti-inflammatory, antiviral and lung-protective action. In relation to the
central nervous system (CNS) it has been shown, in clinical studies, that vitamin D is beneficial in
some neurological and psychiatric conditions because of its anti-inflammatory and antioxidant
properties, modulation of neurotransmitters actions, and regulation of calcium homeostasis between
other mechanisms. It has been shown that COVID-19 infection induces CNS complications such as
headache, anosmia, ageusia, neuropathy, encephalitis, stroke, thrombosis, cerebral hemorrhages, cytotoxic
lesions, and psychiatric conditions and it has been proposed that the use of dietary supplements,
as vitamin and minerals, can be adjuvants in this disease. In this review, the evidence of the
possible role of vitamin D, and its metabolites, as a protector against the neurological manifestations
of COVID-19 was summarized.