bluuebunny/crossref_metadata_2025 huggingface dataset:
Ivy Sign Predicts Ischemic Stroke Recurrence in Adult Moyamoya Patients without Revascularization Surgery
Authors: Nam Ki-Woong , Cho Won-Sang , Kwon Hyung-Min , Kim Jeong Eun , Lee Yong-Seok , Park Sun-Won , Rhim Jung Hyo , Son Young-Je
Published: June 2019

Background: Although there is a standard guideline for performing revascularization surgery in patients with Moyamoya diseases (MMD), more objective and easily obtainable predictors are still needed. Objectives: In this study, we aimed to evaluate the relationship between an ipsilateral ivy sign and ischemic stroke recurrence in adult MMD patients without revascularization surgery. Methods: We included consecutive MMD patients without revascularization surgery between 2006 and 2014. The ivy sign was defined as a linear or focal high-signal intensity on fluid-attenuated inversion recovery images, and the burdens of ivy sign were rated in each hemisphere. The ischemic stroke recurrence was defined as a new clinical event that accompanied a new brain lesion on magnetic resonance imaging. Results: Overall, 84 patients with 154 hemispheres were analyzed. We found recurrent ischemic stroke in 9 (6%) hemispheres within 3 years. In multivariate analysis, an ipsilateral ivy sign remained an independent predictor of 3-year ischemic recurrence (adjusted hazard ratio [aHR] 10.15, 95% CI 2.10–49.14, p = 0.004). An initial presentation as infarction was also significant (aHR 7.15, 95% CI 1.36–36.78, p = 0.019). The burdens of ivy sign showed a dose-response tendency with the 3-year ischemic recurrence rate (p < 0.001). When comparing the ischemic recurrence rate among 4 groups with and without ivy sign and perfusion defect, the “Ivy sign (+) Perfusion defect (+) group” showed a significantly higher risk in both observed (p = 0.005) and estimated (p = 0.003) 3-year ischemic recurrence than did the other group. Additionally, the “Ivy sign (+) Perfusion defect (–) group” showed a higher recurrence rate than did the “Ivy sign (–) Perfusion defect (+) group”. Conclusions: The ivy sign is associated with ischemic recurrence in adult MMD patients in a dose-response manner. It would be helpful for selecting high-risk patients who need revascularization surgery.
Cellular Senescence and the Immune System in Cancer
Authors: Prieto Luis I. , Baker Darren J.
Published: June 2019

In response to a variety of cancer-inducing stresses, cells may engage a stable cell cycle arrest mechanism, termed cellular senescence, to suppress the proliferation of preneoplastic cells. Despite this cell intrinsic tumor suppression, senescent cells have also been implicated as active contributors to tumorigenesis by extrinsically promoting many hallmarks of cancer, including evasion of the immune system. Here, we discuss these dual, and seemingly contradictory, roles of senescence during tumorigenesis. Furthermore, we highlight findings of how senescent cells can influence the immune system and discuss the possibility that immune cells themselves may be acquiring senescence-associated alterations. Lastly, we discuss how senescent cell avoidance or clearance may impact pathology.
Design and Development of Novel 1,3,5-Triazine-Procaine Derivatives as Protective Agent against Myocardial Ischemia/Reperfusion Injury via Inhibitor of Nuclear Factor-κB
Authors: Qiang Zhe , Yu Wenli , Yu Yonghao
Published: June 2019

The aim of the present study was to determine the protective effect of novel 1,3,5-triazine-procaine derivatives against myocardial ischemia/reperfusion (I/R) injury. Initially, the experiment has been started by the synthesis of procaine, which later got substituted with diverse 1,3,5-triazine derivatives to furnish the final compounds. The target compounds were tested for nuclear factor-κB (NF-κB) inhibitory activity in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. The antioxidant activity of most potent compound 9i was investigated using hydroxyl radical, DPPH, and superoxide anion scavenging assay. Compound 9i was further evaluated for protective effect against myocardial I/R injury on the basis numerous parameters, for example, hemodynamic parameters (left ventricular developed pressure [LVDP], ±dp/dtmax, coronary flow [CF], and heart rate [HR]), myocardial enzymes (creatine kinase and lactate dehydrogenase), thiobarbituric acid reactive substance (TBARS), oxidative stress (super oxide dismutase [SOD], catalase [CAT], glutathione [GSH], and glutathione peroxidise [GPx]), histopathology, western blots analysis for B-cell lymphoma 2 (Bcl-2), Bcl-2-associated x protein (Bax), lectin-like oxidized low-density lipoprotein receptor-1 (LOX-1), and NF-κB in cardiac tissues. Compounds showed significant inhibition of NF-ĸB transcriptional activity in LPS-stimulated RAW264.7 cells, revealing compound 9i as a most potent derivative. In vitro results showed efficient reduction of reduced hydroxyl radical, DPPH, and superoxide anion by 9i. The level LVDP, ±dp/dtmax, CF, HR, TBARS, SOD, CAT, GSH, GPx, and damaged cardiac histopathology were completely restored to normal in 9i-treated group, as compared to I/R group. In western blot analysis, the expression of Bax, LOX-1, and NF-ĸB was found to be decreased, while the level of Bcl-2 was found to be increased in 9i-treated group. The procaine-1,3,5-triazine derivatives showed significant cardioprotective action via inhibition of NF-ĸB.
Modeling and simulation of three phases cascaded H-bridge grid-tied PV inverter
Authors: Panigrahi Swetapadma , Thakur Amarnath
Published: June 2019

In this paper a control scheme for three phase seven level cascaded H-bridge inverter for grid tied PV system is presented. As power generation from PV depends on varing environmental conditions, for extractraction of maximum power from PV array, fuzzy MPPT controller is incorporated with each PV array. It gives fast and accurate response. To maintain the grid current sinusoidal under varying conditions, a digital PI controller scheme is adopted. A MATLAB/Simulink model is developed for this purpose and results are presented. At last THD analysis is carried out in order to validate the performance of the overall system. As discussed, with this control strategy the balanced grid current is obtained keeping THD values with in the specified range of IEEE-519 standard.
SOC integration for video processing application
Authors: Cheng Chan Boon , Jambek Asral Bahari
Published: June 2019

Video processing is an additional system that can improve the functionality of video surveillance. Integration of a simple video processing system into a complete camera system with a field-programmable gate array (FPGA) is an important step for research, to further improve the tracking process. This paper presents the integration of greyscale conversion into a complete camera system using Nios II software build tools for Eclipse. The camera system architecture is designed using the Nios II soft-core embedded processor from Altera. The proposed greyscale conversion system is designed using the C programming language in Eclipse. Parts of the architecture design in the camera system are important if greyscale conversion is to take place in the processing, such as synchronous dynamic random-access memory (SDRAM) and a video decoder driver. The image or video is captured using a Terasic TRDB-D5M camera and the data are converted to RGB format using the video decoder driver. The converted data are shown in binary format and the greyscale conversion system extracts and processes the data. The processed data are stored in the SDRAM before being sent to a VGA monitor. The camera system and greyscale conversion system were developed using the Altera DE2-70 development platform. The data from the video decoder driver and SDRAM were examined to confirm that the data conversion matched greyscale conversion formulae. The converted data in the SDRAM correctly displayed the greyscale image on a VGA monitor.
Dynamic evolving neural fuzzy inference system equalization scheme in mode division multiplexer for optical fiber transmission
Authors: Noori Awab , Amphawan Angela , Ghazi Alaan , Aljunid Ghazi S. A.
Published: June 2019

The performance of optical mode division multiplexer (MDM) is affected by inter-symbol interference (ISI), which arises from higher-order mode coupling and modal dispersion in multimode fiber (MMF). Existing equalization algorithms in MDM can mitigate linear channel impairments, but cannot tackle nonlinear channel impairments accurately. Therefore, mitigating the noise in the received signal of MDM in the presence of ISI to recover the transmitted signal is important issue. This paper aims at controlling the broadening of the signal from MDM and minimizing the undesirable noise among channels. A dynamic evolving neural fuzzy inference system (DENFIS) equalization scheme has been used to achieve this objective. Results illustrate that nonlinear DENFIS equalization scheme can improve the received distorted signal from an MDM with better accuracy than previous linear equalization schemes such as recursive‐least‐square (RLS) algorithm. Desirably, this effect allows faster data transmission rate in MDM. Additionally, the successful offline implementation of DENFIS equalization in MDM encourages future online implementation of DENFIS equalization in embedded optical systems.
Design of Ku-band power divider using Substrate Integrated Waveguide technique
Authors: Siang Tan Gan , David Dass David Paul , Ibrahim Siti Zuraidah , A. Karim Mohd Nazri , Dewani Aliya A.
Published: June 2019

A Ku-band Substrate Integrated Waveguide power divider is proposed. In this work, the SIW power divider is designed with T-junction configuration. The SIW technique enables the power divider to have low insertion loss, low cost and features uniplanar circuit. An additional of metallic via hole is added in the center of the junction to improve the return loss performance of the Tjunction SIW power divider. The simulated input return losses at port 1 are better than 27 dB, and features equal power division of about -3.1 dB ±0.4 dB at both output ports across frequency range of 13.5-18 GHz. The SIW power divider is fabricated, and the measurement results show acceptable performances. Since there are some losses contributed by the SMA connector of the fabricated SIW power divider prototype, an additional SIW transmission line is simulated and fabricated to analyze the connector loss.
Scalable workflow scheduling algorithm for minimizing makespan and failure probability
Authors: Aziz Maslina Abdul , Ninggal Izuan Hafez
Published: June 2019

This paper presents an algorithm called Failure-Aware Workflow Scheduling (FAWS). The proposed algorithm discussed in this paper schedules parallel applications on homogeneous systems without sacrificing the two conflicting objectives: reliability and makespan. The proposed algorithm handles unexpected failure causes rescheduling of the failed task to available resources. In order to analyse the performance of the FAWS algorithm, it will be compared with the popular scheduling algorithm namely Heterogeneous Earliest Finish Time (or HEFT) and Critical Path (CP). A simulation-driven analysis based on realistic workflow application was demonstrated using DAG graph as a continuation of the Layered Workflow Scheduling Algorithm (LWFS). The FAWS algorithm aims to minimize the makespan, increases reliability and therefore boosts the performance of the whole system. A workflow generator was developed to generate large task graphs randomly and scheduled the parallel applications. Based on the simulation results, the proposed algorithm has improved the overall workflow scheduling effectiveness in comparison with existing algorithms.
Performance analysis on secured data method in natural language steganography
Authors: Din Roshidi , Bakar Rosmadi , Sabri Raihan Sabirah , Darus Mohamad Yusof , Elias Shamsul Jamel
Published: June 2019

The rapid amount of exchange information that causes the expansion of the internet during the last decade has motivated that a research in this field. Recently, steganography approaches have received an unexpected attention. Hence, the aim of this paper is to review different performance metric; covering the decoding, decrypting and extracting performance metric. The process of data decoding interprets the received hidden message into a code word. As such, data encryption is the best way to provide a secure communication. Decrypting take an encrypted text and converting it back into an original text. Data extracting is a process which is the reverse of the data embedding process. The effectiveness evaluation is mainly determined by the performance metric aspect. The intention of researchers is to improve performance metric characteristics. The evaluation success is mainly determined by the performance analysis aspect. The objective of this paper is to present a review on the study of steganography in natural language based on the criteria of the performance analysis. The findings review will clarify the preferred performance metric aspects used. This review is hoped to help future research in evaluating the performance analysis of natural language in general and the proposed secured data revealed on natural language steganography in specific.
Haze alarm visual map (HazeViz): an intelligent haze forecaster
Authors: Syukri Morsid Mohd Said , Jamaluddin Syeril Azira , Hood Nur Azmina , Shaadan Norshahida , Wah Yap Bee , Annamalai Muthukkaruppan
Published: June 2019

The haze problem has intensified in recent years. The particulate matter of less than 10 microns in size, PM10 is the dominant air pollutant during haze. In this paper, we present the development of HazeViz, a Haze Alarm Visual Map forecaster, which is based on PM10. The intelligent web application allows users to visualize the pattern of PM10 in a region, forecasts PM10 value and alarms bad haze condition. HazeViz was developed using HTML, Java Script, PHP, MySQL, R Programming and Fusionex Giant. The SARIMA statistical forecasting models that underlie the application were developed using R. The PM10 trend analysis, and the consequential map and chart visualizations were implemented on the Fusionex GIANT Big Data Analytics platform. HazeViz was developed in the context of the Klang Valley, our case study. The dataset was obtained from Department of Environment Malaysia, which contains a total of 157,680 hourly PM10 data for six stations in Klang Valley, for the years 2013 to 2015. The SARIMA models were developed using maximum daily PM10 data for 2013 and 2014, and the 2015 data was used to validate the model. The fitting models were determined based on the Mean Absolute Error (MAE), Root Mean Square Error (RMSE) and Mean Absolute Percentage Error (MAPE). While the selected models were implemented in HazeViz and successfully deployed on the web, the results show that the selected models have MAPE ranging between 35 percent and 45 percent, which implies that the models are still far from robust. Future work can consider augmented SARIMA models that can yield improved results.
Food intake gesture monitoring system based-on depth sensor
Authors: Fuad bin Kassim Muhammad , Norzali Haji Mohd Mohd
Published: June 2019

Food intake gesture technology is one of a new strategy for obesity people managing their health care while saving their time and money. This approach involves combining face and hand joint point for monitoring food intake of a user using Kinect Xbox One camera sensor. Rather than counting calories, scientists at Brigham Young University found dieters who eager to reduce their number of daily bites by 20 to 30 percent lost around two kilograms a month, regardless of what they ate [1]. Research studies showed that most of the methods used to count bite are worn type devices which has high false alarm ratio. Today trend is going toward the non-wearable device. This sensor is used to capture skeletal data of user while eating and train the data to capture the motion and movement while eating. There are specific joint to be capture such as Jaw face point and wrist roll joint. Overall accuracy is around 94%. Basically, this increase in the overall recognition rate of this system.
The effects of rain fade on millimetre wave channel in tropical climate
Authors: Budalal Asma Ali , Rafiqul Islam Md , Habaebi Mohamed Hadi , Rahman Tharek Abd.
Published: June 2019

The main objective of this paper to determine multipath and time-varying channel behaviour of short-terrestrial millimetre-wave point-to-point radio links. In an attempt to invigorate the impact of rain attenuation on mm-wave channel parameters such as the RMS delay spread, path loss received power strength and Rician distribution with a K factor. A brief analysis of rain fading was presented based on the simultaneous measurement of one-minute rain rate and its effects on a short experimental link of 38 GHz. Rain fade average is observed as high as 16 dB for 300 m path at about 125 mm/hr rain intensity. The statistical spatial channel mode (SSCM) simulation software was utilized for an operating frequency of 38 GHz. To generate of power delay profile (PDP). For both omnidirectional and directional antenna. The RMS delay spread and path loss has been estimated using the environmental parameters of Kuala Lumpur city which illustrates the theoretical performances of 5G in Malaysia. It is observed that RMS delay spread, path loss received power strength and K factor effected dramatically by rain fade. (SSCM) simulation software has to be modified to consider rain fade dynamic characteristics to achieve ultra-reliability requirements of outdoor applications in the tropical regions. This study is important for understanding signal propagation phenomena in short distance and enabling the utilization of the millimetre wave band for an urban micro-cellular environment for 5G communication system.
Intelligent flood disaster warning on the fly: developing IoT-based management platform and using 2-class neural network to predict flood status
Authors: Abdullahi Salami Ifedapo , Habaebi Mohamed Hadi , Malik Noreha Abd
Published: June 2019

The number of natural disasters occurring yearly is increasing at an alarming rate which has caused a great concern over the well-being of human lives and economy sustenance. The rainfall pattern has also been affected and this has caused immense amount of flood cases in recent times. Flood disasters are damaging to economy and human lives. Yearly, millions of people are affected by floods in Asia alone. This has brought the attention of the government to develop a flood forecasting method to reduce flood casualties. In this article, a flood mitigation method will be evaluated which incorporates a miniaturized flow, water level sensor and pressure gauge. The data from the two sensors are used to predict flood status using a 2-class neural network. Real-time monitoring of the data from the sensor into Thingspeak channel were possible with the use of NodeMCU ESP8266. Furthermore, Microsoft’s Azure Machine Learning (AzureML) has built-in 2-class neural network which was used to predict flood status according to predefine rule. The prediction model has been published as Web services through AzureML service and it enables prediction as new data are available. The experimental result showed that using 3 hidden layers has the highest accuracy of 98.9% and precision of 100% when 2-class neural network is used.
Recyclable waste separation system based on material classification using weight and size of waste
Authors: Midi Nur Shahida , Rahmad Muhammad Aizat , Yusoff Siti Hajar , Mohamad Sarah Yasmin
Published: June 2019

Insufficient landfills problem had increased the needs to decrease the waste and recycling them. However, despite the efforts done by the government and local authorities on promoting recycling culture by introducing new laws and regulations, the awareness and willingness among the community is still low. One of the possible reasons to this is lack of effort to categorize the waste into the designated category which are paper, glass, plastic and metal. In order to address this problem, it is important to design a system that will ease the process of categorizing the waste. This can be achieve by the automation of the said process. In this work, a system consist of an algorithm and hardware to automatically categorize recyclable waste is proposed. The proposed system are utilizing weight sensor and ultrasonic sensors in order to capture the characteristics of the waste item, which are weight and size so that it can be categorized into paper, glass, plastic and metal. Here, a sytem to automatically separate household waste item is presented by combining an algorithm with a set of hardware consist of minimal number of sensors, conveyer belt and servor motors.
Web-Based Yorùbá Numeral Translation System
Authors: Agbeyangi Abayomi Olusola , Eludiora Safiriyu , A Popoola O.
Published: June 2019

Yorùbá numerals have been seen as one of the most interesting but quite complicated numeral system. In this paper we present the development of a web-based English to Yorùbá numeral translation system. The system translates English numbers both in figure and text to its standard Yorùbá form. The computational processes underlying both numerals were used to formulate the model for the work. Unified Modeling language (UML) and Automata theory was used for the system design and specification. The designed system was implemented using Google Web App Engine with support for python. The result of the system evaluation using mean opinion score approach shows that the system gives a recall of 100% on all the output considered.
Gênese de Cavernas da Serra Norte, Carajás, Pará com base em estudos petrográficos e geoquímicos de Formações Ferríferas Bandadas
Authors: Abreu Soraia da Silva , Macambira Joel Buenano , Macambira Moacir José Buenano , Cabral Érica Da Soledade
Published: June 2019

Este trabalho objetiva entender os processos responsáveis pela formação das cavernas desenvolvidas em jaspilitos, no platô de N4, em Carajás, Pará. O estudo baseou-se em análises petrográficas e geoquímicas do jaspilito buscando caracterizar a evolução mineralógica, textural e geoquímica das quatro categorias em que foi classificado, considerando seus graus de alteração intempérica: 1) jaspilito fresco (JF); 2) jaspilito pouco alterado (JPA); 3) jaspilito muito alterado (JMA); 4) minério de ferro (MN). Na transição do JF para o MN ocorre intensa lixiviação de SiO2 (de 62,51 para 0,51%) e consequente enriquecimento no teor de Fe2O3t (de 56,48 para 97,71%). O chert e o jaspe são lixiviados, acarretando a formação de microcavidades de dissolução, até a retirada completa da banda de sílica (na ordem de 50 a 60% em volume). Por outro lado, há neoformação de duas variedades de hematita, a Hm-2 e a Hm-3, além de goethita. Verificou-se que a gênese das cavernas está inicialmente relacionada a processos químicos de dissolução e lixiviação da sílica, que foi ocasionada pela percolação de fluidos de origem meteórica, canalizados pelo do bandamento do jaspilito, aliado também à inclinação das camadas, que serviram de caminhos preferenciais para essas soluções. Processos de erosão subterrânea, colapso e abatimento do material residual aceleraram o aumento dos espaços vazios no jaspilito com a consequente formação das cavernas. Interpreta-se que os processos iniciais que atuaram na formação das cavernas são os mesmos que condicionaram a formação do minério friável da mina estudada.
Petrologia, geoquímica e geocronologia do Granodiorito Presidente Kennedy: contextualização na evolução do Cinturão Araguaia
Authors: Santos Williams Pinto dos , Gorayeb Paulo Sergio De Sousa , Moura Candido Augusto Veloso , Sousa Layse Holanda
Published: June 2019

Diversos corpos graníticos têm sido identificados no extremo leste do Cinturão Araguaia (CA) em seu domínio de mais alto grau metamórfico (Grupo Estrondo). Tais granitos têm sido interpretados como de posicionamento sin a tardi-cinemático em relação à tectônica principal e metamorfismo regional da evolução do CA, no final do Neoproterozóico. Neste contexto o Granodiorito Presidente Kennedy (GPK) localizado a 6 km a noroeste da cidade de Presidente Kennedy (TO) compõe a forma de um stock elíptico, que abrange uma área aflorante cujo diâmetro maior é de aproximadamente 10 km, e o menor de 5 km, encaixado em micaxistos do Grupo Estrondo e parcialmente coberto por rochas sedimentares da Formação Pimenteiras. O estudo petrográfico identificou rochas hololeucocráticas (M<6) granodioríticas e monzograníticas equigranulares, de cor cinza levemente rosada, e com textura granular hipidiomórfica e alotriomórfica. Dados litoquímicos indicam que o GPK tem caráter levemente peraluminoso, com elevados valores SiO2, Al2O3 e álcalis e baixos valores de MgO, Fe2O3t e TiO2. O estudo geocronológico de evaporação de Pb em zircão forneceu idade 539 ± 5 Ma, interpretada como idade mínima de cristalização do GPK. Os estudos petrográficos, geoquímicos e geocronológicos do GPK, indicam semelhanças com os demais granitos ocorrentes no CA. Os estudos isotópicos pelo método Sm-Nd definiram idades modelo (TDM) de 2,13 Ga e 2,17 Ga para o GPK e valores εNd negativos indicando que essa rocha tem proveniência de fonte crustal, gerada da fusão de crosta antiga Paleoproterozóica. Os estudos comparativos indicam semelhanças entre este e os demais granitos do CA, possivelmente cogenéticos relacionado à fase principal do metamorfismo do CA, no limete Neoproterozóico-Paleozóico.
Análise de fácies e ambientes deposicionais do Grupo Vazante na região da mina de Morro Agudo, Paracatu, noroeste do estado de Minas Gerais
Authors: Sotero Marcus Paulo , Caxito Fabrício De Andrade , Dias Paulo Henrique Amorim , Sotero Benjamim Augusto
Published: June 2019

Rochas do Grupo Vazante afloram no noroeste do estado de Minas Gerais, em uma faixa contínua de aproximadamente 250 km, da região de Vazante, ao sul, até Unaí, ao norte. Nessa região está localizada a mina de zinco e chumbo de Morro Agudo, que juntamente com os depósitos de Vazante, Ambrósia e Fagundes, todos hospedados no Grupo Vazante, compõe a principal província zincífera do país. Foram descritas, em seis testemunhos de sondagem e afloramentos de campo na região, 12 fácies sedimentares e quatro associações de fácies (AFs), que indicam deposição em ambiente de margem passiva mista carbonática-siliciclástica. A associação mais basal (AF01) é composta por pelitos e ritmitos silto-arenosos carbonosos, representando sedimentação em plataforma profunda de baixa declividade, em regime de transgressão marinha. Após a inundação máxima, em trato de mar alto, depositou-se a AF02 em ambiente de recife com barreiras em borda de plataforma, composta por dolomitos laminados com estromatólitos, dolarenitos e brechas dolareníticas, e ainda pelitos carbonáticos carbonosos com fácies diamictito. O abaixamento do nível relativo do mar gerou uma regressão forçada e a deposição da AF03 em trato de sistema do estágio de queda. É composta, na base, por diamictito argilo-carbonoso com fragmentos de AF02, passando a pelito e ritmito silto-arenoso. A retomada da subida do nível relativo do mar proporcionou a deposição da AF04 e ainda de rochas da AF03 em posição mais distal. A AF04 é composta por dololutitos argilosos laminados e maciços, e dolarenitos intraclásticos depositados em plataforma carbonática. O padrão de empilhamento observado sugere que a deposição de todas as unidades ocorreu progressivamente, em processo de subida do nível relativo do mar
Geologia e petrologia dos gnaisses da região de São Valério da Natividade, Tocantins
Authors: Borges Gilliard Medeiros , Pierosan Ronaldo , Viana Rubia Ribeiro
Published: June 2019

A região de São Valério da Natividade no estado de Tocantins está relacionada ao Maciço de Goiás e ao Bloco Cavalcante-Natividade, compondo embasamento da Faixa Brasília, constituída dominantemente de complexos gnáissicos migmatíticos paleoproterozoicos ortoderivados de composição granodiorítica a tonalítica. Localmente, ocorrem lentes de xistos metapelíticos, com porfiroblastos de granada e estaurolita, e quartzitos. Os gnaisses ortoderivados apresentam um bandamento contínuo com orientação NE-SW e mergulhos subverticais, enquanto os migmatitos são representados por metatexitos formados em regime compressional e sob influência de zonas de cisalhamento. A xistosidade dos metapelitos é paralela à dos gnaisses e sua associação mineralógica registra um pico metamórfico da fácies anfibolito superior com retrometamorfismo da fácies xisto verde. Com base nas foliações internas dos porfiroblastos de estaurolita dos metapelitos foi possível identificar duas fases de deformação dúctil. A terceira fase é marcada pela xistosidade dos metapelitos e pelo bandamento gnáissico. Uma quarta fase de deformação, de caráter rúptil, também pode ser observada. A composição química dos gnaisses ortoderivados sugere protólito granodiorítico, com características de suítes tonalitotrondhjemito-granodiorito (TTG) calcioalcalinas, contribuição de fusão parcial de fontes tipo MORB, no bloco crustal Cavalcante-Natividade e retrabalhamento crustal nos gnaisses do Maciço de Goiás. Os dados geocronológicos U-Pb de gnaisse ortoderivado em diagrama concórdia apresentam um intercepto superior de 2229 ± 13 Ma, interpretado como idade do protólito, e um intercepto inferior de 614 ± 85 Ma, interpretado como a idade do metamorfismo mais jovem. Idades de cristalização semelhantes foram obtidas para o Domínio Almas-Conceição do Tocantins, também relacionadas a suítes TTGs calcioalcalinas (Suíte Manoel Alves). A idade do metamorfismo é compatível com as idades estimadas para o Ciclo Brasiliano-Pan Africano na
Petrologia do Batólito Sítios Novos, Sistema Orogênico Sergipano, Província Borborema, NE do Brasil
Authors: Pinho Neto Maurício Almeida de , Rosa Maria De Lourdes da Silva , Conceição Herbet
Published: June 2019

O Batólito Sítios Novos (110 km2) é uma intrusão alongada na direção NE-SW, com idade de 631 ± 4 Ma, cuja forma concorda com a orientação regional, e se localiza na região sul do Domínio Poço Redondo, Sistema Orogênico Sergipano. Esse batólito é constituído de monzogranitos leucocráticos com textura alotriomórfica equigranular e inequigranular, e ocasionalmente por diques pegmatíticos. Enclaves máficos são raros. A região sul do batólito é afetada por zona de cisalhamento regional, e os monzogranitos adquirem estruturas milonítica e gnáissica. Oligoclásio e albita são os plagioclásios presentes nesses granitos, e a microclina ocasionalmente é pertítica. A biotita é o mineral máfico dominante e a sua composição indica afinidade com suítes orogênicas (cálcio-alcalina e peraluminosa). Zircão, titanita, magnetita, ilmenita, apatita, torita, allanita e monazita ocorrem como minerais acessórios. Bastanesita e barita ocupam frequentemente microfraturas nessas rochas. A geoquímica dos monzogranitos evidencia que são rochas fracionadas (SiO2 > 68%), peraluminosas a metaluminosas, e alocam-se em diagramas geoquímicos no campo dos granitos do Tipo I. Os espectros dos elementos terras raras apresentam fracionamento moderado (15 < LaN/YbN < 70), com anomalia negativa em Eu sugestivo de fracionamento de plagioclásio. Em diagramas multielementares, as amostras desse batólito apresentam vales pronunciados em Nb, P, Ba e Ti, e picos mais ou menos acentuados em Th, Pb e Zr. Essa assinatura geoquímica é característica de magmas orogênicos. A fonte provável para os monzonitos estudados é uma crosta de composição tonalítica.
Evolução estratigráfica dos depósitos cretáceos da porção norte da Bacia de São Luís-Grajaú (NE do Brasil)
Authors: Cunha João Augusto De Oliveira , Sousa Debora Do Carmo , Córdoba Valéria Centurion
Published: June 2019

Os depósitos cretáceos da Bacia de São Luís-Grajaú são recorrentemente organizados, nos trabalhos prévios, em três sequências deposicionais, consolidadas desde o Neoaptiano até uma idade incerta no Neocretáceo, abrangendo as formações Grajaú e Codó, como também o Grupo Itapecuru. Este trabalho objetivou aplicar a estratigrafia de sequências, com base na correlação de perfis litológicos e de raios gama, na análise dos depósitos cretáceos localizados na parte norte da bacia. Para esse propósito, esta pesquisa utilizou dados de cinco poços, interpretados em uma etapa 1D, que posteriormente serviram de base para a construção de uma seção estratigráfica, interpretada em uma fase 2D. Além disso, trabalhos prévios acerca dos sistemas deposicionais envolvidos na sedimentação desses depósitos cretáceos foram cotejados para propor um modelo evolutivo para o intervalo estudado. A partir da integração dessas interpretações, individualizou-se o intervalo em duas sequências deposicionais (A e B), sendo cada uma delas composta por três tratos de sistemas: de nível baixo (TSNB), transgressivo (TST) e de nível alto (TSNA). A Sequência A foi, primariamente, dominada por processos flúvio-deltaicos correspondentes ao TSNB. Posteriormente, representando o TST, houve a ampliação das fácies lacustres, paralelamente à retração do sistema flúvio-deltaico desenvolvido durante a fase anterior. Finalmente, caracterizando o TSNA, ocorreu uma continuação dos processos suspensivos vistos no TST, porém com a influência de fluxos hiperpicnais. No tocante à Sequência B, inicialmente instalou-se um sistema deltaico representativo do TSNB. Subsequentemente, no TST, esse delta deu lugar a um estuário dominado por ondas. Por fim, em um estágio atribuído ao TSNA, um sistema deltaico novamente se estabeleceu, encerrando assim a história evolutiva do intervalo analisado.
Pedagogia e dispositivos móveis
Authors: Genaro Ednei De , Rocha Nadir Da Silveira Souza
Published: June 2019

Este artigo busca refletir sobre as formas de pensar e posicionar-se diante das transformações nas instituições escolares com a inserção dos dispositivos móveis. Estabelecemos uma leitura crítica das obras de Paula Sibilia, Redes ou paredes, e de Michel Serres, Polegarzinha, conjecturando, sobretudo, a respeito do uso desses dispositivos, conectados à internet e inseridos em sala de aula, na problemática da comunicação pedagógica entre aluno, professor e mídias. Pensar a pedagogia e os dispositivos móveis com base em tais autores nos permite uma dupla perspectiva, indagativa e recursiva. A partir de um debate premente, estabelecemos considerações, análises e hipóteses.
Hacia la enseñanza de otro modelo de periodismo
Authors: Lazcano-Peña Daniela , Gálvez-Pereira María Paz
Published: June 2019

Es posible enseñar y pensar el Periodismo más allá de los espacios y roles tradicionales (medios, organizaciones públicas y empresas)? Con esta pregunta como eje, en este texto presentamos la experiencia del proyecto Cuvic de la Escuela de Periodismo de la Pontificia Universidad Católica de Valparaíso, instancia que mediante el voluntariado vincula a sus estudiantes con establecimientos escolares, y organizaciones del tercer sector para implementar proyectos comunicacionales y periodísticos. Por medio de entrevistas, observamos que los y las estudiantes participantes identifican en Cuvic una propuesta de periodismo no hegemónica, y al servicio de la ciudadanía y del desarrollo social, territorial y comunitario.
Educação para a Comunicação Social: experiências educativas com o jornalismo em Portugal. Entrevista com Manuel Pinto
Authors: Rehder Maria , Saldanha Felipe
Published: June 2019

O diretor do Doutoramento em Ciências da Comunicação da Universidade do Minho (Portugal) e membro do Centro de Estudos de Comunicação e Sociedade (CECS), o professor Manuel Joaquim Silva Pinto, concedeu entrevista exclusiva para a Revista Comunicação & Educação. A conversa foi realizada na ocasião de sua vinda ao Brasil para participar do II Congresso Internacional de Comunicação e Educação, promovido pelo Núcleo de Comunicação e Educação da Universidade de São Paulo (NCE-USP) e Associação Brasileira de Pesquisadores e Profissionais em Educomunicação (ABPEducom), em novembro de 2018, em São Paulo (SP). Manuel Pinto conta o que o motivou a ingressar na área da Educação para a Comunicação Social. Também falou sobre os resultados de suas pesquisas acerca do papel do jornalismo neste campo e destacou a importância de olhar para as crianças não apenas como filhos ou alunos, mas sujeitos que têm direitos de expressão e participação assegurados.
Drug use in delivery hospitalization: Pelotas births cohort, 2015
Authors: Silveira Marysabel Pinto Telis , Miranda Vanessa Iribarrem Avena , Silveira Mariângela Freitas da , Dal Pizzol Tatiane Da Silva , Mengue Sotero Serrate , Bertoldi Andréa Dâmaso
Published: June 2019

OBJECTIVE: Trace the pattern of drug use during delivery hospitalization. METHOD: Cross-sectional study carried out from June to October 2015, included in the 2015 Pelotas births cohort. All women living in the urban area of the city who were hospitalized for delivery were part of the sample. We collected information regarding drug prescription and drug use by mothers during the whole period of hospitalization. Sociodemographic data were obtained in interview after delivery, and other data were obtained from medical charts. The drugs were classified according to the Anatomical Therapeutic Chemical system. RESULTS: All study participants (1,392 women) used at least one drug, with the mean amount being larger the higher the age of the mother, both prepartum/during delivery and postpartum. It was also higher in cases of spinal anesthesia or general anesthesia, cesarean deliveries, school hospitals, and longer hospitalizations. Analysis of the sample as a whole showed no significant difference in the number of drugs used according to hospitalization type, but when stratified by length of hospital stay the mean was higher in SUS hospitalizations than in private and health insurance hospitalizations. Drugs for the nervous system were the most used (30.5%), followed by drugs for the alimentary tract and metabolism (13.8%). The use of anti-infective agents and drugs that act on the cardiovascular and respiratory systems was higher in mothers who underwent cesarean delivery. This study showed high drug consumption in the delivery hospitalization period, and showed cesarean delivery and epidural anesthesia as the main factors related to high drug consumption in this period. CONCLUSIONS: We found high drug consumption in the delivery hospitalization period, and the main factors were cesarean delivery and epidural anesthesia. Drugs that act on the nervous system were the most used.
Systems Pharmacology Identifies an Arterial Wall Regulatory Gene Network Mediating Coronary Artery Disease Side Effects of Antiretroviral Therapy
Authors: Frades Itziar , Readhead Ben , Amadori Letizia , Koplev Simon , Talukdar Husain A. , Crane Heidi M. , Crane Paul K. , Kovacic Jason C. , Dudley Joel T. , Giannarelli Chiara , Björkegren Johan L.M. , Peter Inga
Published: June 2019

Background:

Antiretroviral therapy (ART) for HIV infection increases risk for coronary artery disease (CAD), presumably by causing dyslipidemia and increased atherosclerosis. We applied systems pharmacology to identify and validate specific regulatory gene networks through which ART drugs may promote CAD.

Methods:

Transcriptional responses of human cell lines to 15 ART drugs retrieved from the Library of Integrated Cellular Signatures (overall 1127 experiments) were used to establish consensus ART gene/transcriptional signatures. Next, enrichments of differentially expressed genes and gene-gene connectivity within these ART-consensus signatures were sought in 30 regulatory gene networks associated with CAD and CAD-related phenotypes in the Stockholm Atherosclerosis Gene Expression study.

Results:

Ten of 15 ART signatures were significantly enriched both for differential expression and connectivity in a specific atherosclerotic arterial wall regulatory gene network (AR-RGN) causal for CAD involving RNA processing genes. An atherosclerosis in vitro model of cholestryl ester-loaded foam cells was then used for experimental validation. Treatments of these foam cells with ritonavir, nelfinavir, and saquinavir at least doubled cholestryl ester accumulation (
P
=0.02, 0.0009, and 0.02, respectively), whereas RNA silencing of the AR-RGN top key driver,
PQBP1
(polyglutamine binding protein 1), significantly curbed cholestryl ester accumulation following treatment with any of these ART drugs by >37% (
P
<0.05).

Conclusions:

By applying a novel systems pharmacology data analysis framework, 3 commonly used ARTs (ritonavir, nelfinavir, and saquinavir) were found altering the activity of AR-RGN, a regulatory gene network promoting foam cell formation and risk of CAD. Targeting AR-RGN or its top key driver
PQBP1
may help reduce CAD side effects of these ART drugs.
Novel Drug Targets for Ischemic Stroke Identified Through Mendelian Randomization Analysis of the Blood Proteome
Authors: Chong Michael , Sjaarda Jennifer , Pigeyre Marie , Mohammadi-Shemirani Pedrum , Lali Ricky , Shoamanesh Ashkan , Gerstein Hertzel Chaim , Paré Guillaume
Published: June 2019

Background:

Novel, effective, and safe drugs are warranted for treatment of ischemic stroke. Circulating protein biomarkers with causal genetic evidence represent promising drug targets, but no systematic screen of the proteome has been performed.

Methods:

First, using Mendelian randomization (MR) analyses, we assessed 653 circulating proteins as possible causal mediators for 3 different subtypes of ischemic stroke: large artery atherosclerosis, cardioembolic stroke, and small artery occlusion. Second, we used MR to assess whether identified biomarkers also affect risk for intracranial bleeding, specifically intracerebral and subarachnoid hemorrhages. Third, we expanded this analysis to 679 diseases to test a broad spectrum of side effects associated with hypothetical therapeutic agents for ischemic stroke that target the identified biomarkers. For all MR analyses, summary-level data from genome-wide association studies (GWAS) were used to ascertain genetic effects on circulating biomarker levels versus disease risk. Biomarker effects were derived by meta-analysis of 5 GWAS (N≤20 509). Disease effects were derived from large GWAS analyses, including MEGASTROKE (N≤322 150) and UK Biobank (N≤408 961) studies.

Results:

Several biomarkers emerged as causal mediators for ischemic stroke. Causal mediators for cardioembolic stroke included histo-blood group ABO system transferase, coagulation factor XI, scavenger receptor class A5 (SCARA5), and tumor necrosis factor–like weak inducer of apoptosis (TNFSF12). Causal mediators for large artery atherosclerosis included ABO, cluster of differentiation 40, apolipoprotein(a), and matrix metalloproteinase-12. SCARA5 (odds ratio [OR]=0.78; 95% CI, 0.70–0.88;
P
=1.46×10
−5
) and TNFSF12 (OR=0.86; 95% CI, 0.81–0.91;
P
=7.69×10
−7
) represent novel protective mediators of cardioembolic stroke. TNFSF12 also increased the risk of subarachnoid (OR=1.53; 95% CI, 1.31–1.78;
P
=3.32×10
−8
) and intracerebral (OR=1.34; 95% CI, 1.14–1.58;
P
=4.05×10
−4
) hemorrhages, whereas SCARA5 decreased the risk of subarachnoid hemorrhage (OR=0.61; 95% CI, 0.47–0.81;
P
=5.20×10
−4
). Multiple side effects beyond stroke were identified for 6 of 7 biomarkers, most (75%) of which were beneficial. No adverse side effects were found for coagulation factor XI, apolipoprotein(a), and SCARA5.

Conclusions:

Through a systematic MR screen of the circulating proteome, causal roles for 5 established and 2 novel biomarkers for ischemic stroke were identified. Side-effect profiles were characterized to help inform drug target prioritization. In particular, SCARA5 represents a promising target for treatment of cardioembolic stroke, with no predicted adverse side effects.
Prevalence and Temporal Distribution of Fast and Slow Progressors of Infarct Growth in Large Vessel Occlusion Stroke
Authors: Rocha Marcelo , Desai Shashvat M. , Jadhav Ashutosh P. , Jovin Tudor G.
Published: June 2019

Background and Purpose—

Fast and slow progressors of infarct growth due to anterior circulation large vessel occlusion are commonly observed in clinical practice. We aimed to estimate the prevalence and temporal distribution of fast and slow progressors among anterior circulation large vessel occlusion patients diagnosed within 24 hours of stroke onset.

Methods—

Single-center retrospective study of all patients with anterior circulation large vessel occlusion who underwent baseline computed tomographic perfusion or magnetic resonance imaging within 24 hours of stroke onset. Prevalence was determined for fast progressors (ischemic core >70 mL, <6 hours of stroke onset) and slow progressors (ischemic core ≤30 mL, >6–24 hours of stroke onset).

Results—

One hundred eighty-five patients were included. The median time interval from stroke onset to baseline core imaging was 7.6 hours (interquartile range, 3.9–13.2), and median core volume was 17 mL (range, 0–405). Patients had core volume ≤70 mL in 72% of cases in the overall cohort. The prevalence of fast progressors was 25% (95% CI, 17%–37%) and reached 40% (95% CI, 24%–59%) between 3 and 4.5 hours after stroke onset. The prevalence of slow progressors was 55% (95% CI, 46%–64%) and was similar across time intervals beyond 6 hours after stroke onset.

Conclusions—

Most anterior circulation large vessel occlusion patients had small-to-moderate ischemic core volume, irrespective of early or delayed presentation within 24 hours of stroke onset. Fast progressors were highly prevalent between 3 and 4.5 hours after stroke onset.
Recent Nationwide Impact of Mechanical Thrombectomy on Decompressive Hemicraniectomy for Acute Ischemic Stroke
Authors: Rumalla Kavelin , Ottenhausen Malte , Kan Peter , Burkhardt Jan-Karl
Published: June 2019

Background and Purpose—

The treatment of patients with acute ischemic stroke has been revolutionized by endovascular mechanical thrombectomy (MT), leading to dramatically improved outcomes. Here, we analyzed the impact of recent changes in stroke management on nationwide trends in patient characteristics, treatment modalities, and outcomes.

Methods—

The National Inpatient Sample was analyzed using
International Classification of Diseases, Ninth and Tenth Editions
, Clinical Modification codes to identify adult stroke patients with anterior-circulation, large-vessel occlusion in the pre- (2012–2014) and the post-MT trial period (2015–2016). Univariate and multivariable predictors of decompressive hemicraniectomy (DHC) were ascertained in patients developing malignant cerebral edema.

Results—

The nationwide query identified 519 320 adult stroke patients with annually increasing volume (92 320 to 129 340), stroke severity, and treatment at urban teaching centers. DHC was performed in 9.5% of patients developing malignant cerebral edema (n=33 530) and was associated with a high rate of discharge to long-term nursing care (65%) and mortality (23%). Over time, the rate of MT (3.4% to 9.8%) increased whereas the rate of DHC for malignant cerebral edema declined from 11.4% to 4.8% (
P
<0.001). In a binary logistic regression model controlling for potential confounders (eg, age, severity of illness), MT patients were 43% less likely to require DHC (odds ratio, 0.7; 95% CI, 0.6–0.9).

Conclusions—

Nationwide trends indicated that successful reperfusion of penumbra with MT in stroke patients leads to a declining indication for DHC whereas stroke volume increases over time.
Tingidae (Hemiptera: Heteroptera) from Laos: new species and new records
Authors: GUILBERT ERIC
Published: June 2019

Eight species new to science are described from Laos, and 19 species are newly recorded from Laos. A key to genera and species is provided.
Synopsis of lobatifrons species-group (Hymenoptera: Bethylidae, Rhabdepyris) from Neotropical region, with redefinition of the group
Authors: STEIN P. R.W. , AZEVEDO C. O.
Published: June 2019

The  lobatifrons species-group of Neotropical region is redefined as to include the Rhabdepyris species with appendicular process at cuspis in the male genitalia. Rhabdepyris latissimus sp. nov., R. callosus sp. nov., R. concavus sp. nov. and R. demissus sp. nov. are described and illustrated. New geographical records and taxonomical data on R. septemlineatus Kieffer, 1906, R. quinquilineatus Kieffer, 1906, R. luteipennis, Evans, 1965, R. atlanticus Rosmann & Azevedo, 2005 are provided. R. lobatifrons Kieffer, 1910 is a junior synonym of R. septemlineatus. A key to males are given.