bluuebunny/crossref_metadata_2025 huggingface dataset:
Persistence of Anti-S1 IgG against SARS-CoV-2 Eight Months after the Booster Dose of Vaccine in Naive and Previously Infected Healthcare Workers
Authors: Algarate Sonia , Serrano Laura , Bueno Jessica , Herrero-Cortina Beatriz , Alvarado Elena , González-Barriga María T. , Ducons María , Montero-Marco Jesica , Arnal Sara , Acha Beatriz , Riesgo María , Taboada Ana , Sanz-Burillo Pilar , Yuste Cristina , Benito Rafael ,   on behalf of the RIPOVAC Study Group
Published: June 2023

Our aim was to evaluate the immune response of healthcare workers included in the RIPOVAC study, after receiving a booster dose (third dose), in terms of intensity and persistence of induced antibodies. In the second phase of the RIPOVAC study, between December 2021 and January 2022, eight months after the second dose, 389 voluntary, immunocompetent, non-pregnant healthcare workers received a booster dose of SARS-CoV-2 vaccine, and a serum sample was obtained. Two groups of patients were established: with and without previous SARS-CoV-2 infection. In order to quantify anti-S1 IgG (AU/mL) we used CMIA (Abbott). All of the health workers were anti-S IgG positive 8 months after receiving the booster dose of the vaccine, with a mean of 17,040 AU/mL. In 53 patients without previous infection, antibody levels increased by a mean of 10,762 AU/mL. This figure is seven times higher than the one produced after the second dose (1506 AU/mL). The booster dose produces a robust elevation of the antibody level, which persists at 8 months, with levels significantly higher than those reached after the second dose, which allow one to predict a persistence of more than one year. The study demonstrates the efficacy of the booster dose of anti-SARS-CoV-2 vaccines.
Sirt6 Activation Ameliorates Inflammatory Bone Loss in Ligature-Induced Periodontitis in Mice
Authors: Lee Myung Jin , Ryu Hyang Hwa , Hwang Jae Won , Kim Jung Ryul , Cho Eui-Sic , Choi Jin Kyeong , Moon Young Jae
Published: June 2023

Periodontitis is an inflammatory disease caused by microorganisms that induce the destruction of periodontal tissue. Inflamed and damaged tissue produces various inflammatory cytokines, which activate osteoclasts and induce alveolar bone loss and, eventually, tooth loss. Sirt6 expression suppresses inflammation and bone resorption; however, its role in periodontitis remains unclear. We hypothesized that Sirt6 has a protective role in periodontitis. To understand the role of Sirt6 in periodontitis, we compared periodontitis with ligature placement around the maxillary left second molar in 8-week-old control (C57BL/6J) male mice to Sirt6-overexpressing Tg (Sirt6Tg) mice, and we observed the resulting phenotypes using micro-CT. MDL801, a Sirt6 activator, was used as a therapy for periodontitis through oral gavage. Pro-inflammatory cytokines and increased osteoclast numbers were observed in alveolar bone tissue under periodontitis surgery. In the same condition, interestingly, protein levels from Sirt6 were the most downregulated among sirtuins in alveolar bone tissue. Based on micro-CT and CEJ-ABC distance, Sirt6Tg was observed to resist bone loss against ligature-induced periodontitis. Furthermore, the number of osteoclasts was significantly reduced in Sirt6Tg-ligated mice compared with control-ligated mice, although systemic inflammatory cytokines did not change. Consistent with this observation, we confirmed that bone loss was significantly reduced when MDL801, a Sirt6 activator, was included in the ligation mouse model. Our findings demonstrate that Sirt6 activation prevents bone loss against ligature-induced periodontitis. Thus, a Sirt6 activator may provide a new therapeutic approach for periodontitis.
Prenatal SAMe Treatment Changes via Epigenetic Mechanism/s USVs in Young Mice and Hippocampal Monoamines Turnover at Adulthood in a Mouse Model of Social Hierarchy and Depression
Authors: Becker Maria , Gorobets Denis , Shmerkin Elena , Weinstein-Fudim Liza , Pinhasov Albert , Ornoy Asher
Published: June 2023

The role of hippocampal monoamines and their related genes in the etiology and pathogenesis of depression-like behavior, particularly in impaired sociability traits and the meaning of changes in USVs emitted by pups, remains unknown. We assessed the effects of prenatal administration of S-adenosyl-methionine (SAMe) in Sub mice that exhibit depressive-like behavior on serotonergic, dopaminergic and noradrenergic metabolism and the activity of related genes in the hippocampus (HPC) in adulthood in comparison to saline-treated control Sub mice. During postnatal days 4 and 8, we recorded and analyzed the stress-induced USVs emitted by the pups and tried to understand how the changes in the USVs’ calls may be related to the changes in the monoamines and the activity of related genes. The recordings of the USVs showed that SAMe induced a reduction in the emitted flat and one-frequency step-up call numbers in PND4 pups, whereas step-down type calls were significantly increased by SAMe in PND8 pups. The reduction in the number of calls induced by SAMe following separation from the mothers implies a reduction in anxiety, which is an additional sign of decreased depressive-like behavior. Prenatal SAMe increased the concentrations of serotonin in the HPC in both male and female mice without any change in the levels of 5HIAA. It also decreased the level of the dopamine metabolite DOPAC in females. There were no changes in the levels of norepinephrine and metabolites. Several changes in the expression of genes associated with monoamine metabolism were also induced by prenatal SAMe. The molecular and biochemical data obtained from the HPC studies are generally in accordance with our previously obtained data from the prefrontal cortex of similarly treated Sub mice on postnatal day 90. The changes in both monoamines and their gene expression observed 2–3 months after SAMe treatment are associated with the previously recorded behavioral improvement and seem to demonstrate that SAMe is effective via an epigenetic mechanism.
The Application of Microwaves, Ultrasounds, and Their Combination in the Synthesis of Nitrogen-Containing Bicyclic Heterocycles
Authors: Frecentese Francesco , Sodano Federica , Corvino Angela , Schiano Marica Erminia , Magli Elisa , Albrizio Stefania , Sparaco Rosa , Andreozzi Giorgia , Nieddu Maria , Rimoli Maria Grazia
Published: June 2023

The use of alternative energy sources, such as microwaves (MW) or ultrasounds (US), and their mutual cross-combination have been widely described in the literature in the development of new synthetic methodologies in organic and medicinal chemistry. In this review, our attention is focused on representative examples, reported in the literature in the year range 2013–2023 of selected N-containing bicyclic heterocycles, with the aim to highlight the advantages of microwave- and ultrasound-assisted organic synthesis.
Monocytes in the Characterization of Pain in Palliative Patients with Severe Dementia—A Pilot Study
Authors: Ribeiro Hugo , Alves Raquel , Jorge Joana , Gonçalves Ana Cristina , Sarmento-Ribeiro Ana Bela , Teixeira-Veríssimo Manuel , Andrade José Paulo , Dourado Marília
Published: June 2023

In assessing and managing pain, when obtaining a self-report is impossible, therapeutic decision-making becomes more challenging. This study aimed to investigate whether monocytes and some membrane monocyte proteins, identified as a cluster of differentiation (CD), could be potential non-invasive peripheral biomarkers in identifying and characterizing pain in patients with severe dementia. We used 53 blood samples from non-oncological palliative patients, 44 patients with pain (38 of whom had dementia) and 0 without pain or dementia (controls). We evaluated the levels of monocytes and their subtypes, including classic, intermediate, and non-classic, and characterized the levels of specific phenotypic markers, namely CD11c, CD86, CD163, and CD206. We found that the relative concentrations of monocytes, particularly the percentage of classic monocytes, may be a helpful pain biomarker. Furthermore, the CD11c expression levels were significantly higher in patients with mixed pain, while CD163 and CD206 expression levels were significantly higher in patients with nociceptive pain. These findings suggest that the levels of monocytes, particularly the classic subtype, and their phenotype markers CD11c, CD163, and CD206 could serve as pain biomarkers in patients with severe dementia.
Roles of Rac1-Dependent Intrinsic Forgetting in Memory-Related Brain Disorders: Demon or Angel
Authors: Wang Wei , Wang Zixu , Cao Jing , Dong Yulan , Chen Yaoxing
Published: June 2023

Animals are required to handle daily massive amounts of information in an ever-changing environment, and the resulting memories and experiences determine their survival and development, which is critical for adaptive evolution. However, intrinsic forgetting, which actively deletes irrelevant information, is equally important for memory acquisition and consolidation. Recently, it has been shown that Rac1 activity plays a key role in intrinsic forgetting, maintaining the balance of the brain’s memory management system in a controlled manner. In addition, dysfunctions of Rac1-dependent intrinsic forgetting may contribute to memory deficits in neurological and neurodegenerative diseases. Here, these new findings will provide insights into the neurobiology of memory and forgetting, pathological mechanisms and potential therapies for brain disorders that alter intrinsic forgetting mechanisms.
The Presence of T Allele (rs35705950) of the MUC5B Gene Predicts Lower Baseline Forced Vital Capacity and Its Subsequent Decline in Patients with Hypersensitivity Pneumonitis
Authors: Lewandowska Katarzyna B. , Szturmowicz Monika , Lechowicz Urszula , Franczuk Monika , Błasińska Katarzyna , Falis Maria , Błaszczyk Kamila , Sobiecka Małgorzata , Wyrostkiewicz Dorota , Siemion-Szcześniak Izabela , Bartosiewicz Małgorzata , Radwan-Röhrenschef Piotr , Roży Adriana , Chorostowska-Wynimko Joanna , Tomkowski Witold Z.
Published: June 2023

Hypersensitivity pneumonitis (HP) is an exposure-related interstitial lung disease with two phenotypes—fibrotic and non-fibrotic. Genetic predisposition is an important factor in the disease pathogenesis and fibrosis development. Several genes are supposed to be associated with the fibrosing cascade in the lungs. One of the best-recognized and most prevalent is the common MUC5B gene promoter region polymorphism variant rs35705950. The aim of our study was to establish the frequency of the minor allele of the MUC5B gene in the population of patients with HP and to find the relationship between the MUC5B promoter region polymorphism and the development of lung fibrosis, the severity of the disease course, and the response to the treatment in patients with HP. Eighty-six consecutive patients with HP were tested for the genetic variant rs35705950 of the MUC-5B gene. Demographic, radiological, and functional parameters were collected. The relationship between the presence of the T allele and lung fibrosis, pulmonary function test parameters, and the treatment response were analyzed. The minor allele frequency in the study group was 17%, with the distribution of the genotypes GG in 69.8% of subjects and GT/TT in 30.2%. Patients with the GT/TT phenotype had significantly lower baseline forced vital capacity (FVC) and significantly more frequently had a decline in FVC with time. The prevalence of lung fibrosis in high-resolution computed tomography (HRCT) was not significantly increased in GT/TT variant carriers compared to GG ones. The patients with the T allele tended to respond worse to immunomodulatory treatment and more frequently received antifibrotic drugs. In conclusions: The frequency of MUC5B polymorphism in HP patients is high. The T allele may indicate a worse disease course, worse immunomodulatory treatment response, and earlier need for antifibrotic treatment.
Endosome Traffic Modulates Pro-Inflammatory Signal Transduction in CD4+ T Cells—Implications for the Pathogenesis of Systemic Lupus Erythematosus
Authors: Park Joy S. , Perl Andras
Published: June 2023

Endocytic recycling regulates the cell surface receptor composition of the plasma membrane. The surface expression levels of the T cell receptor (TCR), in concert with signal transducing co-receptors, regulate T cell responses, such as proliferation, differentiation, and cytokine production. Altered TCR expression contributes to pro-inflammatory skewing, which is a hallmark of autoimmune diseases, such as systemic lupus erythematosus (SLE), defined by a reduced function of regulatory T cells (Tregs) and the expansion of CD4+ helper T (Th) cells. The ensuing secretion of inflammatory cytokines, such as interferon-γ and interleukin (IL)-4, IL-17, IL-21, and IL-23, trigger autoantibody production and tissue infiltration by cells of the adaptive and innate immune system that induce organ damage. Endocytic recycling influences immunological synapse formation by CD4+ T lymphocytes, signal transduction from crosslinked surface receptors through recruitment of adaptor molecules, intracellular traffic of organelles, and the generation of metabolites to support growth, cytokine production, and epigenetic control of DNA replication and gene expression in the cell nucleus. This review will delineate checkpoints of endosome traffic that can be targeted for therapeutic interventions in autoimmune and other disease conditions.
Risk Factors for Conversion from Laparoscopic to Open Appendectomy
Authors: Bancke Laverde Bruno Leonardo , Maak Matthias , Langheinrich Melanie , Kersting Stephan , Denz Axel , Krautz Christian , Weber Georg F. , Grützmann Robert , Brunner Maximilian
Published: June 2023

(1) Background: Since its introduction in the 1990s, laparoscopic appendectomy has become established over the years and is today considered the standard therapy for acute appendicitis. In some cases, however, a conversion to the open approach is still necessary. The primary aim of this study was to identify risk factors for the need to convert from the laparoscopic to an open approach during appendectomy for acute appendicitis. (2) Methods: A retrospective analysis of 1220 adult patients who underwent laparoscopic appendectomy for acute appendicitis from 2010 to 2020 at the University Hospital Erlangen was performed. Data, including patient demographics and pre-, intra-, and postoperative findings, were collected and compared between patients with and without conversion. (3) Results: The conversion rate in our cohort was 5.5%. A higher preoperative WBC count and CRP (OR 1.9, p = 0.042, and OR 2.3, p = 0.019, respectively), as well as the presence of intraoperative perforation, necrosis or gangrene, perityphlitic abscess and peritonitis (OR 3.2, p = 0.001; OR 2.3, p = 0.023; OR 2.6, p = 0.006 and OR 2.0, p = 0.025, respectively) were identified as independent risk factors for conversion from the laparoscopic to the open approach. Conversion was again independently associated with higher morbidity (OR 2.2, p = 0.043). (4) Conclusion: The laparoscopic approach is feasible and safe in the majority of patients with acute appendicitis. Only increased inflammatory blood markers could be detected as the preoperative risk factors potentially influencing the choice of surgical approach but only with low specificity and sensitivity. For the decision to convert, intraoperative findings are additionally crucial. However, patients with conversion should receive special attention in the postoperative course, as these have an increased risk of developing complications.
Review of the Immune Checkpoint Inhibitors in the Context of Cancer Treatment
Authors: Alturki Norah A.
Published: June 2023

Checkpoint proteins are an integral part of the immune system and are used by the tumor cells to evade immune response, which helps them grow uncontrollably. By blocking these proteins, immune checkpoint inhibitors can restore the capability of the immune system to attack cancer cells and stop their growth. These findings are backed by adequate clinical trial data and presently, several FDA-approved immune checkpoint inhibitors exist in the market for treating various types of cancers, including melanoma, hepatocellular, endometrial, lung, kidney and others. Their mode of action is inhibition by targeting the checkpoint proteins CTLA-4, PD-1, PD-L1, etc. They can be used alone as well as in amalgamation with other cancer treatments, like surgery, radiation or chemotherapy. Since these drugs target only specific immune system proteins, their side effects are reduced in comparison with the traditional chemotherapy drugs, but may still cause a few affects like fatigue, skin rashes, and fever. In rare cases, these inhibitors are known to have caused more serious side effects, such as cardiotoxicity, and inflammation in the intestines or lungs. Herein, we provide an overview of these inhibitors and their role as biomarkers, immune-related adverse outcomes and clinical studies in the treatment of various cancers, as well as present some future perspectives.
Analysis of Ischemia-Modified Albumin (IMA) and Coagulation Parameters in Patients with SARS-CoV-2 Pneumonia
Authors: Saglam Emel , Sener Gulsen , Bayrak Tulin , Bayrak Ahmet , Gorgulu Numan
Published: June 2023

Background: Coronavirus disease 2019 (COVID-19) is a systemic disease which causes an increased inclination to thrombosis by leading to coagulation system activation and endothelial dysfunction. Our objective in this study is to determine whether ischemia-modified albumin (IMA) can be used as a new marker in patients with COVID-19 for evaluating the increased coagulation risk, pneumonic infiltration, and thus, prognosis. Methods: Our study included 59 patients with COVID-19 compatible pneumonic infiltration on lung computed tomography (CT) who applied to and were hospitalized in the Internal Diseases Outpatient Clinic, then followed up and treated, as well as 29 healthy individuals with a negative COVID-19 rRT-PCR test without any additional disease. Hemogram, coagulation, routine biochemistry, and serum IMA activity parameters were studied. Results: In our study, the higher serum IMA level in COVID-19 patients with pneumonic infiltration compared to that of the healthy control group was found to be statistically significant. No significant correlation was found between the serum IMA levels and the coagulation and inflammation parameters in the 59 COVID-19 patients included. Conclusions: Serum IMA levels in COVID-19 patients with pneumonic infiltration on CT were found to be higher than in the control group. Examination of biochemical parameters, especially thrombotic parameters that affect prognosis such as IMA, can be a guide in estimating pneumonic infiltration.
An Overview of Systemic Health Factors Related to Rapid Oral Health Deterioration among Older People
Authors: van der Putten Gert-Jan , de Baat Cees
Published: June 2023

The oral health of older individuals can be negatively impacted by various systemic health factors, leading to rapid oral health deterioration. This paper aims to present an overview of the published evidence on systemic health factors that contribute to rapid oral health deterioration in older individuals, and to explore the implications of these factors for both general healthcare and oral healthcare provision. Older people are at risk of experiencing adverse reactions to medications due to multimorbidity, polypharmacy, and changes in pharmacokinetics and pharmacodynamics. Hyposalivation, a significant side effect of some medications, can be induced by both the type and number of medications used. Frailty, disability, sarcopenia, care dependency, and limited access to professional oral healthcare can also compromise the oral health of older people. To prevent rapid oral health deterioration, a comprehensive approach is required that involves effective communication between oral healthcare providers, other healthcare providers, and informal caregivers. Oral healthcare providers have a responsibility to advocate for the importance of maintaining adequate oral health and to raise awareness of the serious consequences of weakened oral health. By doing so, we can prevent weakened oral health from becoming a geriatric syndrome.
Prospects of Endovenous Laser Ablation (EVLA) Standardization—Mid-Term Results of a Four-Zone Dosimetry Guiding Tool for 1940 nm Laser
Authors: Setia Abhay , Dikic Slobodan , Demhasaj Sahit , Schmitz-Rixen Thomas , Sroka Ronald , Schmedt Claus-Georg
Published: June 2023

Background: Heterogeneity regarding dosimetry and reporting of endovenous laser ablation (EVLA) mandates the development of a standardized protocol. This study presents the mid-term results of EVLA with 1940 nm-laser and radial-fibre, supported by a four-zone dosimetry tool. Materials and methods: Four anatomical dosimetry zones for great saphenous veins (GSV) and two for small saphenous veins (SSV) were defined with set power levels. Zone-1G (4 W) extended from the inguinal ligament to the apex of femoral triangle, Zone-2G (4 W) from the apex of femoral triangle to the upper border of patella. Zone-3G (3 W) from the patella to the tibial tuberosity. Zone-4G (2 W) extended from the tibial tuberosity to the ankle. Zone-1S from the sapheno-popliteal junction to the tibial tuberosity. Zone-2S from the tibial tuberosity to the ankle. Power was increased by 1 W for veins >10 mm and decreased by 1 W when fibre sticking was encountered. Pullback-velocity was max. 1 mm/s. Results: A total of 152 consecutive patients (185 procedures) were recruited. Mean follow-up time was 11.9 months. Mean linear endovenous energy density for GSV was Zone-1G:42 J/cm, Zone-2G:33 J/cm, Zone-3G:27 J/cm, Zone-4G:22 J/cm, Zone-1S:34 J/cm, Zone-2S:27 J/cm. Occlusion rates were 98.9% (1-month) and 93.7% (12-months). Complications at 1 M were low, namely laser-induced paraesthesia (LIP) 2.2% and endovenous heat-induced thrombosis (EHIT) 1.6%. Persistent LIP (12 M) was observed in 0.5%. Conclusion: The proposed four-zone guiding tool is a step towards standardizing dosimetry and documentation for EVLA with 1940 nm. This strategy shows good mid-term results with minimal complications. Long-term follow-up and application in further centres are necessary to prove its reproducibility. Such a guiding tool could improve the ability to analyse, compare and review different EVLA wavelengths and fibre types.
Effect of Ketamine on Postoperative Neurocognitive Disorders: A Systematic Review and Meta-Analysis
Authors: Viderman Dmitriy , Aubakirova Mina , Nabidollayeva Fatima , Yegembayeva Nurgul , Bilotta Federico , Badenes Rafael , Abdildin Yerkin
Published: June 2023

Background: Neurocognitive alterations in the perioperative period might be caused by a wide variety of factors including pain, blood loss, hypotension, hypoxia, micro- and macroemboli, cardiopulmonary bypass (CPB), reperfusion damage, and surgery itself, and all are risk factors for developing postoperative delirium (POD) and postoperative cognitive dysfunction (POCD). The objective of this study was to evaluate the effect of ketamine on neurocognitive dysfunction after anesthesia. Methods: We conducted a meta-analysis of randomized controlled trials (RCTs) comparing ketamine use (experimental group) with placebo (controls). Results: The model favors the control group over the experimental group in terms of frequency of hallucinations (the risk ratio with 95% CI is 1.54 [1.09, 2.19], p-value = 0.02), the number of patients readmitted within 30 days (RR with 95% CI is 0.25 [0.09, 0.70]), and the number of adverse events (overall RR with 95% CI is 1.31 [1.06, 1.62]). In terms of morphine consumption, the model favors the experimental group. Conclusion: There was no statistically significant difference in incidences of postoperative delirium, vasopressor requirement, and fentanyl consumption between the ketamine and control groups. However, hallucinations were more frequently reported in the ketamine group.
The Resolution of Periodontal Inflammation Promotes Changes in Cytokine Expression in the Intestine and Gingival Tissues of Aged Rats with DSS-Induced Colitis
Authors: de Mello-Neto João Martins , Ervolino Edilson , Elangovan Gayathiri , Toro Luan Felipe , Lee Jaehee , Gustafsson Anders , Figueredo Carlos Marcelo da Silva
Published: June 2023

Our research aimed to explore how resolving periodontal inflammation impacts cytokine expression in the colons of aged Wistar rats. Research studies involving animals have been conducted to investigate the two-way relationship between periodontitis and inflammatory bowel disease (IBD), where chronic inflammation in either the mouth or intestines can negatively affect the other. We allocated seventeen male Wistar rats aged between 8 and 11 months to one of four groups: (1) ligature-induced periodontitis (LIP) without the resolution of periodontal inflammation (RPI) (LIP; n = 4), (2) LIP + RPI (n = 4), (3) LIP + dextran-sulphate-sodium-induced colitis (DIC) without RPI (n = 4), and LIP + DIC + RPI (n = 5). We performed histopathological and immunological analyses on periodontal and intestinal tissues and analysed cytokine expressions using a Rat Cytokine 23-Plex Immunoassay. Our findings showed that animals with and without DIC who underwent RPI showed significantly lower levels of IL-2, IL-4, IL-5, IL-10, IL-13, IL-17, IL-18, and TNF-α in the intestine compared to those without treatment. The RPI effectively reduced the number of inflammatory cells in the lamina propria and restored the epithelial barrier in the intestine in animals with DIC. The resolution of periodontal inflammation significantly reduced the levels of pro-inflammatory cytokines and chemokines in the intestines of aged rats with and without DSS-induced colitis.
Fertility Preservation in Women with Endometriosis
Authors: Rangi Sabrina , Hur Christine , Richards Elliott , Falcone Tommaso
Published: June 2023

Several mechanisms have been implicated in the pathogenesis of endometriosis-related infertility. For patients considering surgery, the risk of iatrogenic injury is among the most important factors in the context of fertility preservation, along with age and individual reproductive goals. In the case of endometrioma excision, evidence overwhelmingly demonstrates the negative impact of surgery on ovarian reserve, with significant reductions in antimullerian hormone (up to 30% in unilateral versus up to 44% in bilateral endometriomas). The surgical endometriosis patient should be thoroughly counseled regarding fertility preservation and discussion should include tissue, embryo, and oocyte cryopreservation options. For the latter, data support cryopreservation of 10–15 oocytes in women ≤35 years and over 20 for those >35 years for a realistic chance to achieve one or more live births. When performing surgical interventions for endometriosis, reproductive surgeons should employ fertility-conserving surgical methods to reduce the likelihood of postoperative iatrogenic diminished ovarian reserve.
Occult Pneumothorax in Blunt Thoracic Trauma: Clinical Characteristics and Results of Delayed Tube Thoracostomy in a Level 1 Trauma Center
Authors: Kim Chang-Wan , Park Il-Hwan , Youn Young-jin , Byun Chun-Sung
Published: June 2023

Occult pneumothorax in blunt trauma patients is often diagnosed only after computed tomography because supine chest X-ray (CXR) is preferred as an initial evaluation. However, improperly managed preexisting occult pneumothorax could threaten the vitality of patients. Therefore, this study aimed to evaluate the incidence, characteristics, risk factors, and outcomes of occult pneumothorax in a single trauma center. From 2020 to 2022, patients who were admitted to the level 1 trauma center were retrospectively investigated. Inclusion criteria focused on blunt chest trauma. Variables including demographic factors, image findings, injury-related factors, tube thoracostomy timing, and treatment results were evaluated. Of the 1621 patients, 187 who met the criteria were enrolled in the study: 32 with overt pneumothorax and 81 with occult pneumothorax. Among all of the pneumothorax cases, the proportion of occult pneumothorax was 71.7% (81/113), and its incidence in all admitted trauma victims was 5.0% (81/1621). Subcutaneous emphysema and rib fractures on supine CXR were risk factors for occult pneumothorax. Six patients underwent delayed tube thoracostomy; however, none had serious complications. Given that occult pneumothorax is common in patients with blunt chest trauma, treatment plans should be established that consider the possibility of pneumothorax. However, the prognosis is generally good, and follow-up is an alternative.
Proposal of Restrictions on the Departure of Korea Small Fishing Vessel according to Wave Height
Authors: Jeong Yeonju , Im Namkyun
Published: June 2023

The Korean government imposes departure restrictions on fishing vessels of a gross tonnage of less than 15 tons under adverse weather conditions when significant wave heights exceed 3 m. However, an analysis of small fishing vessels indicates that frequent capsizing accidents occur even under the current departure restrictions of permission when significant wave heights are below 3 m. In this study, we propose new guidelines for regulating the departure of Korean small fishing vessels based on adverse weather conditions. To achieve this, we compare departure restrictions under weather deterioration for small fishing vessels in different countries worldwide with those in Korea. Additionally, by incorporating experimental research conducted in the United Kingdom on the capsizing of fishing vessels, we present a new departure restriction equation considering the ship characteristics (a narrow beam-to-length ratio) of Korean fishing vessels measuring 24 m or less. Through this analysis, we provide detailed guidelines for departure restrictions on Korean small fishing boats based on their length and wave height. To validate the proposed guidelines, we analyze fishing vessel capsizing accidents that occurred near the Korean coast over the past 23 years and demonstrate the utility of the new guidelines by applying them to past capsizing incidents.
State-of-the-Art in Ports and Terminal Management and Engineering
Authors: Park Nam Kyu
Published: June 2023

Ports and terminal management, coupled with engineering practices, play a critical role in facilitating global trade and optimizing logistics operations [...]
Departure Vessel Scheduling Optimization Considering Traffic Restrictions in Turning Basin: A Case Study for Xuwen Terminal
Authors: Jia Qiong , Li Ronghui , Li Jiawen
Published: June 2023

As the largest modern passenger Roll-on Roll-off (RoRo) terminal around the world, the berthing operation of Xuwen terminal is occasionally suspended due to bad weather, such as strong wind or thick fog. During the suspension, the number of stranded passengers and vehicles increasingly accumulates. As soon as the weather permits, the growth exerts great pressure, especially on large-scale vessels leaving the port, whose inefficiency may cause a loss of access to the terminal for inbound ships and chaos for port management. The focus of this study is to improve the efficiency of departure scheduling by optimizing traffic rules in the harbor basin. A mathematical optimization model is formulated for minimizing the total scheduling time, and then an adaptive simulated annealing (ASA) algorithm is proposed to solve the model. A specific decoding rule is introduced, referring to the characteristics of the mentioned model. After employing the operation data of the Xuwen terminal, a numerical experiment showed that the proposed scheduling method outperformed the first-come, first-served (FCFS) strategy and an improved ant colony algorithm (ACA). Moreover, the constructed simulation model of the terminal manifested the validity of the optimal solution.
Criteria Selection of Housing Loan Based on Dominance-Based Rough Set Theory: An Indian Case
Authors: Singh Anupama , Singh Aarti , Sharma Haresh Kumar , Majumder Saibal
Published: June 2023

Because India has one of the world’s fastest-growing economies, the Indian banking sector is essential to the country’s reform. The approval of home loans to customers is one of the crucial tasks carried out by Indian banks. The risk of loan repayment outside of the agreed-upon time frame can be reduced by accurately estimating the customer’s loan need. The majority of earlier studies on the development of banking lacked a methodical approach to analyze qualitative data. Even though the traditional multivariate statistically based factor analysis approach is a great way to categories data in qualitative analysis, the technique cannot be used without any statistical presumptions and additional information about the data. This study handles the banking attributes related to home loans using the Dominance-based Rough Set Approach (D-RSA). In order to categorize the customer’s attributes, this study suggests using a preference-based “if … then” decision rule. This rule can aid decision makers in understanding the risk factors associated with loan factors for a financial organization.
Phytochemical Screening and Antimicrobial Activity of Methanolic Extract of Cymbopogon schoenanthus (L.) (azkhar) Collected from Afif City, Saudi Arabia
Authors: Mokhtar Leila M. , Salim Inaam A. , Alotaibi Setah N. , Awaji Eman A. , Alotaibi Maha M. , Doman Ayidah O.
Published: June 2023

In Saudi Arabia, Cymbopogon schoenanthus (L.) has been traditionally used to treat a variety of diseases. This study aimed to investigate the crude methanolic extract of Cymbopogon schoenanthus (L.) phytochemical, chemical composition, and antibacterial activity. Phytochemical analysis revealed the presence of tannins, poly-tannins, steroids, alkaloids, essential oils, terpenoids, and flavonoids. The presence of functional groups such as -COOH, -OH, -C=O, and CH2 was revealed via FTIR spectroscopy. 13C and 1H NMR (nuclear magnetic resonance) were used to determine the types and number of protons (hydrogen atoms) and their electronic states. Using an agar well diffusion assay, methanolic extract of Cymbopogon schoenanthus (L.) inhibited the growth of some foodborne pathogenic bacteria in zones ranging from 8 to 25 mm in diameter. The minimum inhibitory concentration (MIC) for Staphylococcus aureus was 12.5 mg/mL, whereas it was 25 mg/mL for Bacillus cereus, Klebsiella pneumoniae, and Escherichia coli. The time–kill assay revealed a sharp decline in Staphylococcus aureus and Klebsiella pneumonia after 2 h at a concentration of 150 mg/mL, while Bacillus cereus and Escherichia coli showed a gradual decline with constant concentrations of 75 to 150 mg/mL. The minimum bactericide concentration (MBC) value for Bacillus cereus, Staphylococcus aureus, and Escherichia coli was 50 mg/mL, while it was 25 mg/mL for Klebsiella pneumoniae. In conclusion, our study revealed that Cymbopogon schoenanthus (L.) methanolic extract has a significant antibacterial effect, suggesting that it could be used to treat various foodborne pathogens.
Special Issue “Liver Fibrosis: Mechanisms, Targets, Assessment and Treatment”
Authors: Weiskirchen Ralf , Sauerbruch Tilman
Published: June 2023

Fibrosis is a double-edged sword [...]
4,7-Dimethoxy-6-propyl-2H-1,3-benzodioxole-5-carbaldehyde
Authors: Tsyganov Dmitry V. , Semenov Victor V.
Published: June 2023

A simple intermediate for the synthesis of methoxy-analogues of coenzymes Q with substituents having various chain lengths based on natural polyalkoxyallylbenzene apiol has been developed.
Research Progress and Hot Spot Analysis of the Propagation and Evolution Law of Prefabricated Cracks in Defective Rocks
Authors: Zhu Shu , Zhu Zhende , Wang Luxiang , Wu Junyu
Published: June 2023

The generation of rock mass disasters in underground engineering essentially arises from the disruption of the original three-dimensional stress equilibrium of the rock mass caused by excavation and other activities, leading to the redistribution of stress fields. During the excavation process, the engineering rock mass undergoes complex dynamic stress equilibrium processes involving loading and unloading. This equilibrium process promotes the nucleation, initiation, and propagation of pre-existing cracks in the surrounding rock, resulting in changes in the internal structure of the rock mass and a weakening of its strength. Eventually, this localized cracking extends to global failure. In order to understand the current status better and study the development trends in the study of crack propagation and evolution in defective rock, this study conducts a bibliometric analysis of 288 articles from the Web of Science Core Collection database using CiteSpace software (version 6.1.R4). The results indicate an increasing trend in the annual publication output, characterized by two phases of emergence and rapid development. The countries of China, the United States, and Iran have the highest publication output in this field. The most frequently cited journals include INT J ROCK MECH MIN, ENG FRACT MECH, and ROCK MECH ROCK ENG. This study provides a comprehensive analysis of the current status and development trends in the research on the propagation and evolution of pre-existing cracks. This study enhances the comprehension of crucial aspects of crack propagation and evolution in rock materials with defects. Moreover, it opens up new possibilities for future investigations and holds promising implications for researchers and practitioners in the field.
A Simulation Model for the Inductor of Electromagnetic Levitation Melting and Its Validation
Authors: Nycz Błażej , Przyłucki Roman , Maliński Łukasz , Golak Sławomir
Published: June 2023

This article presents a numerical model of electromagnetic levitation melting and its experimental validation. Levitation melting uses the phenomenon of magnetic induction to float a melted, usually metallic, conductor in an electromagnetic field. With the appropriate configuration of the coil (the source of the alternating magnetic field), the eddy currents induced in the molten batch interact with the coil magnetic field, which causes the melted metal to float without direct contact with any element of the heating system. Such a contactless process is very beneficial for melting very reactive metals (e.g., titanium) or metals with a high melting point (e.g., tungsten). The main disadvantage of levitation melting is the low efficiency of the process. The goal of the authors is to develop, by means of a numerical simulation and optimization tools, a system for levitation melting with acceptable efficiency. To achieve this, it is necessary to develop a reliable and representative computational model. The proposed model includes an analysis of the electromagnetic field, with innovative modeling of the convective heat transport. Experimental validation of the model was performed using aluminum alloy, due to the lack of the need to use a protective atmosphere and the ease of measurements. The measurements included electrical values, the melted batch positions during levitation, the melting time, and the temperature distribution in its area. The verification showed that the compliance between the computational model and the simulation for the position of the batch was accurate to 2 mm (6.25%), and the consistency of the batch melting time was accurate to 5 s (5.49%). The studies confirmed the good representativeness of the developed numerical model, which makes it a useful tool for the future optimization of the levitation melting system.
One- and Two-Particle Correlation Functions in the Cluster Perturbation Theory for Cuprates
Authors: Kuz’min Valerii I. , Nikolaev Sergey V. , Korshunov Maxim M. , Ovchinnikov Sergey G.
Published: June 2023

The physics of high-Tc superconducting cuprates is obscured by the effect of strong electronic correlations. One way to overcome this problem is to seek an exact solution at least within a small cluster and expand it to the whole crystal. Such an approach is at the heart of cluster perturbation theory (CPT). Here, we developed CPT for the dynamic spin and charge susceptibilities (spin-CPT and charge-CPT), with the correlation effects explicitly taken into account by the exact diagonalization. We applied spin-CPT and charge-CPT to the effective two-band Hubbard model for the cuprates obtained from the three-band Emery model and calculated one- and two-particle correlation functions, namely, a spectral function and spin and charge susceptibilities. The doping dependence of the spin susceptibility was studied within spin-CPT and CPT-RPA, that is, the CPT generalization of the random phase approximation (RPA). In the underdoped region, both our methods resulted in the signatures of the upper branch of the spin excitation dispersion with the lowest excitation energy at the (π,π) wave vector and no presence of low-energy incommensurate excitations. In the high doping region, both methods produced a low energy response at four incommensurate wave vectors in qualitative agreement with the results of the inelastic neutron scattering experiments on overdoped cuprates.
Optimization Analysis of Overlap Ratio in Wide and Heavy Plate Slitting Shear
Authors: Liao Yachu , Fang Wei , Li Jiahui , Dang Zhang , Li Meng , Shi Wenbin
Published: June 2023

In studying planar multi-bar mechanisms with multiple degrees of freedom, mathematical modeling is undoubtedly a way to get closer to the expected trajectory. Compared with the analytical method, the optimization method has higher accuracy in solving nonlinear equations, and it can be searched and iterated in an extensive range until it meets the real engineering solution. The research on the overlap ratio of the Slitting Shear essentially aims to study the kinematics of the two-DOF mechanism. In this study, a one-DOF mathematical model of mechanical motion was established for the Slitting Shear without considering the overlap ratio. The mathematical model was then verified through simulation. The overlap ratio was introduced based on the above mathematic model, and the three-DOF mathematic model of the shear mechanism was established. Finally, the setting of the overlap ratio was optimized using the conjugate gradient method and the global optimal NMinmize function. Under the condition of satisfying the overlap ratio, the recommended value for the overlap ratio setting of the two-DOF mechanism, which approximates the pure rolling cut, was determined.
NMR Magnetic Shielding in Transition Metal Compounds Containing Cadmium, Platinum, and Mercury
Authors: Zapata-Escobar Andy D. , Maldonado Alejandro F. , Mendoza-Cortes Jose L. , Aucar Gustavo A.
Published: June 2023

In this article, we delve into the intricate behavior of electronic mechanisms underlying NMR magnetic shieldings σ in molecules containing heavy atoms, such as cadmium, platinum, and mercury. Specifically, we explore PtXn−2 (X = F, Cl, Br, I; n = 4, 6) and XCl2Te2Y2H6 (X = Cd, Hg; Y = N, P) molecular systems. It is known that the leading electronic mechanisms responsible for the relativistic effects on σ are well characterized by the linear response with elimination of small components model (LRESC). In this study, we present the results obtained from the innovative LRESC-Loc model, which offers the same outcomes as the LRESC model but employs localized molecular orbitals (LMOs) instead of canonical MOs. These LMOs provide a chemist’s representation of atomic core, lone pairs, and bonds. The whole set of electronic mechanisms responsible of the relativistic effects can be expressed in terms of both non-ligand-dependent and ligand-dependent contributions. We elucidate the electronic origins of trends and behaviors exhibited by these diverse mechanisms in the aforementioned molecular systems. In PtX4−2 molecules, the predominant relativistic mechanism is the well-established one-body spin–orbit (σSO(1)) mechanism, while the paramagnetic mass–velocity (σMv) and Darwin (σDw) contributing mechanisms also demand consideration. However, in PtX6−2 molecules, the σ(Mv/Dw) contribution surpasses that of the SO(1) mechanism, thus influencing the overall ligand-dependent contributions. As for complexes containing Cd and Hg, the ligand-dependent contributions exhibit similar magnitudes when nitrogen is substituted with phosphorus. The only discrepancy arises from the σSO(1) contribution, which changes sign between the two molecules due to the contribution of bond orbitals between the metal and tellurium atoms.
Optimal Investment of Merton Model for Multiple Investors with Frictions
Authors: Chebbi Souhail , Ounaies Senda
Published: June 2023

We investigate the classical optimal investment problem of the Merton model in a discrete time with market friction due to loss of wealth in trading. We consider the case of a finite number of investors, with the friction for each investor represented by a convex penalty function. This model cover the transaction costs and liquidity models studied previously in the literature. We suppose that each investor maximizes their utility function over all controls that keep the value of the portfolio after liquidation non-negative. In the main results of this paper, we prove the existence of an optimal strategy of investment by using a new approach based on the formulation of an equivalent general equilibrium economy model via constructing a truncated economy, and the optimal strategy is obtained using a classical argument of limits.
Hydro-Mechanical Coupling of Cement-Based Slurry Grouting in Saturated Geomaterials
Authors: Wang Haitao , Kou Lei , Zhu Hongkang
Published: June 2023

A mathematical model is proposed to simulate the fully hydro-mechanical coupling of two-phase cement-based slurry migration in saturated deformable geomaterials from microscopic to macroscopic scale. The mass conservation equations and the momentum balance equations for cement-based slurry and geomaterials are derived based on the thermodynamically constrained averaging theory (TCAT). The Galerkin discretization of the governing equations of hydro-mechanical coupling are developed by the isogeometric analysis (IGA) integrated with the Bézier extraction operator, and the numerical calculation is implemented with the generalized backward Euler method. The presented modeling is verified by comparison of the numerical calculation with the experimental tests, and the pore fluid pressure of the stratum and the slurry concentration of cement-based slurry migration in saturated deformable geomaterials are discussed. The modeling presented provides an effective alternative method to simulate cement-based slurry migration and explore isothermal multiphase coupled problems.
Bayesian Subset Selection of Seasonal Autoregressive Models
Authors: Amin Ayman A. , Emam Walid , Tashkandy Yusra , Chesneau Christophe
Published: June 2023

Seasonal autoregressive (SAR) models have many applications in different fields, such as economics and finance. It is well known in the literature that these models are nonlinear in their coefficients and that their Bayesian analysis is complicated. Accordingly, choosing the best subset of these models is a challenging task. Therefore, in this paper, we tackled this problem by introducing a Bayesian method for selecting the most promising subset of the SAR models. In particular, we introduced latent variables for the SAR model lags, assumed model errors to be normally distributed, and adopted and modified the stochastic search variable selection (SSVS) procedure for the SAR models. Thus, we derived full conditional posterior distributions of the SAR model parameters in the closed form, and we then introduced the Gibbs sampler, along with SSVS, to present an efficient algorithm for the Bayesian subset selection of the SAR models. In this work, we employed mixture–normal, inverse gamma, and Bernoulli priors for the SAR model coefficients, variance, and latent variables, respectively. Moreover, we introduced a simulation study and a real-world application to evaluate the accuracy of the proposed algorithm.