bluuebunny/crossref_metadata_2025 huggingface dataset:
Se eu abrir esta porta agora... (2018): projeto gráfico-editorial e perspectivas de leitura
Authors: Domingues Haline Nogueira da Silva , Marson Cíntia Roberto , Martha Alice Áurea Penteado
Published: September 2020

Este artigo tem por objetivo analisar o projeto gráfico-editorial da obra Se eu abrir esta porta agora... (2018), de Alexandre Rampazo, de modo a compreender o alcance dos efeitos de sentido na relação entre forma e conteúdo. Desse modo, pretendemos observar como o projeto gráfico do livro, ao materializar a abertura das portas, de diferentes maneiras, indicia distintas perspectivas de leitura, conforme o modo como, ou de que lado, são abertas as tais portas. O projeto gráfico do livro citado faz uma emulação das portas que podem se abrir de diferentes maneiras ao leitor, revelando também distintas perspectivas de leitura, de acordo com o lado em que tais portas são abertas. A metáfora da porta sugere uma aventura escondida em cada uma delas, as quais podem ser abertas, desvelando mistérios, desejos, medos e inúmeras surpresas. Ganhador do Prêmio FNLIJ 2019, nas categorias Criança e Projeto-Editorial, o livro se destaca pelo caráter inovador e inusitado, oferecendo ao leitor uma proposta divertida pelo universo paralelo tecido entre a realidade e a ficção, encorajando-o a enfrentar seus medos e ter coragem para abrir cada porta e, consequentemente, a viver uma nova experiência literária.
Foot-and-Mouth Disease Virus 3B Protein Interacts with Pattern Recognition Receptor RIG-I to Block RIG-I–Mediated Immune Signaling and Inhibit Host Antiviral Response
Authors: Zhang Xiangle , Zhu Zixiang , Wang Congcong , Yang Fan , Cao Weijun , Li Pengfei , Du Xiaoli , Zhao Furong , Liu Xiangtao , Zheng Haixue
Published: September 2020

Foot-and-mouth disease is a highly contagious disease of pigs, sheep, goats, bovine, and various wild cloven-hoofed animals caused by foot-and-mouth disease virus (FMDV) that has given rise to significant economic loss to global livestock industry. FMDV 3B protein is an important determinant of virulence of the virus. Modifications in 3B protein of FMDV considerably decrease virus yield. In the current study, we demonstrated the significant role of 3B protein in suppression of type I IFN production and host antiviral response in both human embryonic kidney HEK293T cells and porcine kidney PK-15 cells. We found that 3B protein interacted with the viral RNA sensor RIG-I to block RIG-I–mediated immune signaling. 3B protein did not affect the expression of RIG-I but interacted with RIG-I to block the interaction between RIG-I and the E3 ubiquitin ligase TRIM25, which prevented the TRIM25-mediated, Lys63-linked ubiquitination and activation of RIG-I. This inhibition of RIG-I–mediated immune signaling by 3B protein decreased IFN-β, IFN-stimulated genes, and proinflammatory cytokines expression, which in turn promoted FMDV replication. All of the three nonidentical copies of 3B could inhibit type I IFN production, and the aa 17A in each copy of 3B was involved in suppression of IFN-related antiviral response during FMDV infection in porcine cells. Together, our results indicate the role of 3B in suppression of host innate immune response and reveal a novel antagonistic mechanism of FMDV that is mediated by 3B protein.
Solitary late metastasis of primary renal cell carcinoid tumor to the extraocular muscles imaged with indium-111 octreotide
Authors: Dempsey Philip , O'Connell Martin , Bolster Ferdia
Published: September 2020

A 75-year-old male presented with right eye pain and proptosis. His history was significant for renal cell carcinoma treated with left nephrectomy 2 years previously. Computed tomography (CT) imaging demonstrated a 1.6-cm enhancing lesion in the right retrobulbar space. Surgical biopsy revealed a low-grade metastatic carcinoid tumor. At retrospective review, the primary renal lesion from 2 years prior was rediagnosed as consistent with a renal carcinoid tumor. Indium-111 octreotide single photon emission CT/CT imaging demonstrated a solitary metastasis within the right extraocular muscles. The patient subsequently developed additional metastases within the remaining right kidney and lung.
30 mCi exploratory scan for two-step dosimetric 131I therapy in differentiated thyroid cancer patients: A novel approach and case report
Authors: Wu Di , Gomes-Lima Cristiane , Kulkarni Kanchan , Burman Kenneth , Wartofsky Leonard , Van Nostrand Douglas
Published: September 2020

Differentiated thyroid cancer patients with significantly elevated or rapidly rising serum thyroglobulin (Tg) levels and negative diagnostic radioiodine scans (DxScan) often present a therapeutic dilemma in deciding whether or not to administer an 131I treatment. In this report, we describe a novel two-step approach of a 30 mCi 131I exploratory scan before a dosimetric 131I therapy to help “un-blind” the treating physician of the benefit/risk ratio of a further “blind”131I treatment. A 51-year-old man presented with rising Tg levels, a negative DxScan, and a history of widely metastatic follicular thyroid cancer. He had undergone total thyroidectomy, remnant ablation with 3.8 GBq (103.5 mCi) of 131I, Gammaknife®, and treatment with 12.1 GBq (326 mCi) of 131I for multiple metastases. However, at 19 months after the treatments, his Tg levels continued to rise, and scans demonstrated no evidence of radioiodine-avid metastatic disease. In anticipation of a “blind”131I treatment, the medical team and the patient opted for a 30 mCi exploratory scan. The total dosimetrically guided prescribed activity (DGPA) was decided based on the whole-body dosimetry. The patient was first given 30 mCi of 131I, and the exploratory scan was performed 22 h later, which demonstrated 131I uptake in the left lung, left humeral head, T10, and right proximal thigh muscle. Based on the positive exploratory scan, the remainder of the DGPA was administered within several hours after the scan. On the post-DGPA treatment scan performed at 5—7 days, the lesions seen on the ~ 22 h exploratory scan were confirmed, and an additional lesion was observed in the left kidney. The 30 mCi exploratory scan suggested the potential for a response in the radioiodine-avid lesions despite a negative diagnostic scan. This method allows 131I treatment to be administered to patients who may have a greater potential for a therapeutic response while avoiding unwarranted side effects in those patients with nonavid disease.
Clinically occult image revelations of fluorodeoxyglucose positron emission tomography/computed tomography in a peculiar case of sinonasal myeloid sarcoma
Authors: Mathew Shema , Muthukrishnan Indirani , Simon Shelley
Published: September 2020

Myeloid sarcoma (MS) is a sparse association of acute myeloid leukemia (AML) with poor overall survival. Sinonasal involvement in MS is rarer and meagerly studied. Recent prospective studies have underlined the importance of positron emission tomography/computed tomography (PET/CT) in disease assessment and relapse detection in extramedullary (EM) AML. Herein, we report a case of MS with sinonasal, orbital, dural, breast, pleural extent of disease with sacral neural foraminal compression. Initial histopathologic and clinicoradiologic features had pointed toward lymphoma. Immunohistochemistry (IHC) on the contrary revealed MS. Although the role of IHC in asserting the diagnosis of MS is remarkable, PET/CT surpasses other modalities in early detection of EM sites of involvement, overall assessment of disease burden, targeting therapy, prognostication, and relapse recognition. Inclusion of PET/CT as a baseline imaging modality can be beneficial in tailoring patient management to improve survival and overall quality of life.
Monte Carlo simulation and performance assessment of GE Discovery 690 VCT positron emission tomography/computed tomography scanner
Authors: Kashian Elham , Ahangari Hadi , Dehlaghi Vahab , Khoshgard Karim , Ghafarian Pardis , Ghorbani Raheb
Published: September 2020

The aim of this study is to simulate GE Discovery 690 VCT positron emission tomography/computed tomography (PET/CT) scanner using Geant4 Application for Tomographic Emission (GATE) simulation package (version 8). Then, we assess the performance of scanner by comparing measured and simulated parameter results. Detection system and geometry of PET scanner that consists of 13,824 LYSO crystals designed in 256 blocks and 24 ring detectors were modeled. In order to achieve a precise model, we verified scanner model. Validation was based on a comparison between simulation data and experimental results obtained with this scanner in the same situation. Parameters used for validation were sensitivity, spatial resolution, and contrast. Image quality assessment was done based on comparing the contrast recovery coefficient (CRC) of simulated and measured images. The findings demonstrate that the mean difference between simulated and measured sensitivity is <7%. The simulated spatial resolution agreed to within <5.5% of the measured values. Contrast results had a slight divergence within the range below 4%. The image quality validation study demonstrated an acceptable agreement in CRC for 8:1 and 2:1 source-to-background activity ratio. Validated performance parameters showed good agreement between experimental data and simulated results and demonstrated that GATE is a valid simulation tool for simulating this scanner model. The simulated model of this scanner can be used for future studies regarding optimization of image reconstruction algorithms and emission acquisition protocols.
Rest/stress intradermal lymphoscintigraphy in diagnosis of lipedema
Authors: Tartaglione Girolamo , Visconti Giuseppe , Bartoletti Roberto , Ieria Francesco , Salgarello Marzia
Published: September 2020

Lipedema is a chronic and progressive disease characterized by a symmetrical and bilateral swelling of the lower extremities. In general, the feet are not involved. Lipedema is believed to affect nearly 1 in 9 adult women worldwide. Despite this relatively common disease, lipedema is often confused with primary lymphedema or obesity. In clinically advanced lipedema stages, fat continues to build up and may block the lymphatic vessels causing a secondary lymphedema (Lipo-Lymphedema). We consecutively evaluated 54 women with a clinical diagnosis of lower limbs lipedema. Two doses of 99mTc-nanocolloid were injected intradermally at the first intermetatarsal space and in the lateral malleolar area. Two static planar scans were taken at rest immediately following the intradermal injection. Subsequently, all patients were asked to perform an isotonic muscular exercise (stepping) for 2 min. Then, post exercise scans were performed to monitor the tracer pathway. Subsequently, the patient was asked to take a 30–40 min walk (prolonged exercise) and delayed scans were acquired. In early clinical stages, the lymphatic flow is usually preserved and the rest/stress intradermal lymphoscintigraphy may visualize a normal lymphatic drainage with a frequent pattern (tortuous course) of the leg lymphatic pathway. In clinically advanced stages, lymph stagnation areas were observed. Unlike obesity, lipedema fat storage is resistant to dietary regimen, bariatric surgery, and physical activity. Surgical treatment (tumescent liposuction and reductive surgery) is the most effective treatment to remove adipose tissue. Complex decongestive therapies are helpful in reducing the lymph stagnation, especially in patients with advanced lipolymphedema.
Evaluation of estrogen expression of breast cancer using 18F-FES PET CT-A novel technique
Authors: Seenu Vuthaluru , Sharma Ankit , Kumar Rakesh , Suhani Suhani , Prashanth Arun , Mathur Sandeep , Parshad Rajinder
Published: September 2020

Estrogen receptor (ER) expression in breast cancer is routinely studied on immunohistochemistry (IHC) of tissue obtained from core biopsy or surgical specimen. Sampling error and heterogeneity of tumor may incorrectly label a breast tumor as ER negative, thus denying patient hormonal treatment. Molecular functional ER imaging can assess the in-vivo ER expression of primary tumor and metastases at sites inaccessible for biopsy and also track changes in expression over time. The aim was to study ER expression using 16α-18F-fluoro-17β-estradiol or 18F-fluoroestradiol (18F FES) positron emission tomography (PET) computed tomography (CT). Twenty-four biopsy-proven breast cancer patients consenting to participate in the study underwent FES PET CT. Standard uptake value (SUVmean) of maximum of 7 lesions/patient was analyzed, and tumor-to-background ratio was calculated for each lesion. Visual interpretation score was calculated for lesion on FES PET and correlated with the Allred score on IHC of tumor tissue samples for ER expression. The diagnostic indices of FES PET CT were assessed taking IHC as “gold standard.” On FES PET CT, the mean SUV for ER+ tumors was 4.75, whereas the mean SUV for ER − tumors was 1.41. Using receiver operating characteristic curve, tumors with an SUV of ≥ 1.8 on FES PET could be considered as ER+. The overall accuracy of FES PET CT to detect ER expression was 91.66%, with two false negatives noted in this study. 18F-FES PET CT appears promising in evaluating ER expression in breast cancer. It is noninvasive and has potential to assess the in-vivo ER expression of the entire primary tumor and metastasis not amenable for biopsy.
18F-fluorodeoxyglucose positron emission tomography/computed tomography as a metabolic marker for functional assessment of spinal tuberculosis after early decompression surgery
Authors: Rangan Kasturi , Israrahmed Amrin , Suraj Ajay , Gambhir Sanjay
Published: September 2020

Tuberculosis (TB) of the spine is the most important extra pulmonary form of TB. The lytic destructive variant of spinal TB can destroy the intervertebral discs, vertebral body, collapse, kyphotic deformity, and spinal cord compression. Complicated Pott's disease if not managed early can lead to neurological deficits, so there is a need for early surgical decompression, compliant anti-tubercular therapy, and response evaluation tool. We present two cases of multilevel dorsal spinal TB diagnosed on magnetic resonance imaging spine and baseline 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/computed tomography (PET/CT) scan. They underwent early decompression with internal fixation and were followed up for 18 months with serial 18F-FDG PET/CT at 3rd and 18th month, respectively. One patient showed an early complete metabolic response and excellent functional recovery. Another patient showed progressive disease (drug-resistant status) and delayed functional recovery. 18F-FDG PET/CT has an excellent role in assessing response to therapy and thus helps to achieve therapeutic endpoint.
Precise localization of biliary leak post laparoscopic cholecystectomy with hepatobiliary scintigraphy and adjunct single-photon emission tomography/computed tomography fusion imaging
Authors: Shikare Shekhar , El Hakeem Ahmed
Published: September 2020

Laparoscopic cholecystectomy is commonly performed as the treatment of choice for symptomatic gallstone diseases. Bile leak is a potential complication of this procedure and the cystic duct stump is the most common site of leakage. Early diagnosis and treatment of bile leak is crucial in decreasing the morbidity and mortality related to this complication. We present a case of biliary leak following laparoscopic cholecystectomy, diagnosis of active biliary leak, and accurate localization of the site of biliary leak on hepatobiliary scintigraphy and adjunct single-photon emission computed tomography/computed tomography fusion imaging.
Quality of surface water and generation of sludge at water treatment plants
Authors: Fiore Fabiana Alves , Rodgher Suzelei , Ito Cristiane Yumi Koga , Bardini Vivian Silveira dos Santos , Klinsky Luis Miguel Gutiérrez
Published: September 2020

Among the waste produced daily by communities are those resulting from the treatment of water for public supply, with local specificities that reflect the characteristics and uses of the land. Despite the continuous generation and inadequate disposal still current in Brazil, there is little information on these residues. The data related to the composition of these sludges are essential for the study of alternatives for beneficial uses and for determining the risks to the environment and human health from inadequate disposal. It is in this context that the present study was developed, with the objective of identifying the physical-chemical characteristics of sludge produced in water treatment plants (WTPs) and of verifying the presence of these elements in the waters of the source used for supply. Such research was carried out through a case study in two WTPs in the state of São Paulo that perform surface abstraction. Therefore, in each of the WTPs, samples of densified sludge, representative of the dry and rainy periods, were characterized. The chemical findings of the sludge have been compared to the historical series of a decade of monitoring of the water quality of the sources of these WTPs. Among the main results, concentrations above the reference limits for the inert residues of aluminum, iron, manganese and barium in sludge are highlighted, as well as the existence of iron and manganese in the raw water collected and the variations in the concentrations of iron, sodium and manganese in the sludge due to the climatic conditions.
Evaluation of physicochemical water parameters in watersheds of southern Brazil
Authors: Sória Marta , Tavares Vitor Emanuel Quevedo , Pinto Marília Alves Brito , Stumpf Lizete , Zarnott Daiane , Bubolz Jéssica , Nörenberg Bernardo Gomes
Published: September 2020

Water-quality monitoring is one of the main instruments for water-resource management. This work therefore evaluated the water quality of the contribution basin of the Sinnott water treatment plant as well as the relationship between physicochemical water parameters, and analyzed the seasonal variation of water quality parameters as a function of rainfall. The study area encompassed the contribution basin of the Sinnott water treatment plant, formed mainly by the drainage areas of the Pelotas stream and its tributary, the Quilombo Stream, located in the city of Pelotas - Rio Grande do Sul, Brazil. A set of 118,368 data points for each stream was analyzed between 2007 and 2012. The following water quality parameters were evaluated: turbidity, temperature, color, pH, hardness, dissolved oxygen, organic matter, and alkalinity. Results showed that dissolved oxygen and water pH values conformed with Brazilian legislation in the 6 years evaluated. However, water color was the parameter that remained the greatest number of days above the set limits, mainly in the Pelotas Stream. Result indicates the need for conservation actions in the catchment, especially considering the importance of color for the assessment of water quality for public supply, in terms of both treatment costs and of public health. Highest values for water color, turbidity, and organic matter coincided with the occurrence of the highest rainfall values. Agricultural activities may potentiate sedimentation in the contribution basin of the Sinnott water treatment plant.
Homology supported in Lagrangian submanifolds in mirror quintic threefolds
Authors: López Garcia Daniel
Published: September 2020

In this note, we study homology classes in the mirror quintic Calabi–Yau threefold that can be realized by special Lagrangian submanifolds. We have used Picard–Lefschetz theory to establish the monodromy action and to study the orbit of Lagrangian vanishing cycles. For many prime numbers

$p,$
we can compute the orbit modulo p. We conjecture that the orbit in homology with coefficients in

$\mathbb {Z}$
can be determined by these orbits with coefficients in

$\mathbb {Z}_p$
.
Assessment of Some Immune Components from The Bioactive Crude Extract Derived from The Epidermal Mucus of Climbing Perch Anabas Testudines
Authors: al-Rasheed Agharid , Handool Kareem Obayes , Alhelli Amaal M , Garba Bashiru , Muhialdin Belal J , Masomian Malihe , Hani Homayoun , Daud Hassan Hj Mohd
Published: September 2020

Fish and other members of the aquatic habitats are usually in constant interaction with their habitat and potentially harmful pathogens. This study was undertaken to evaluate some of the immune components in the bioactive crude obtained from epidermal mucus of climbing perch. The enzyme activities were assessed using the spectrophotometer and turbidometric assay for the lysozyme activity, and while antimicrobial peptides were determined via AKTA Purifier 10 FPLC with a Superdex™ peptide 10/300 GL column and Q-TOF LC/MS for characterization. Likewise, the antibacterial activity against P. aeruginosa ATCC 10451 was achieved using chromatography fractions. Results showed that higher activities of lysozyme and protease were present in the crude extract. While values for alkaline phosphatase and esterase activities varied. The data analysis of Q-TOF LC/MS showed apolipoprotein A1, haemoglobin subunit beta (Fragment), elongation factor 1-alpha, cytochrome C oxidase subunit1 (Fragment), Beta-actin (Fragment) and potent antimicrobial peptides including de novo AAGPKGPLGPR peptide in crude. This result emphasizes their role in protecting to climbing perch from foreign invaders as a part of the innate immune system throughout the epidermal mucus. The bioactive crude has a high potential to be used as a natural antimicrobial agent for pharmaceutical applications.
Dissemination and Reterritorialization
Authors: Huang Kuan-min
Published: September 2020

Confucianism as a mode of life was brought to Taiwan as early as Chinese settlement. Regarding Confucian philosophy, however, it must be traced back to the founding of modern institutions. Even though the historical background of the Chinese diaspora after 1949 is rather complex, it seems possible to examine how it has contributed to the development of academic disciplines in Taiwan, especially with regard to Confucianism. The present paper investigates the corresponding contributions of two philosophers, Tang Junyi (1909–1978) and Mou Zongsan (1909–1995). Both are important scholars, who are indispensable for the development of contemporary intellectual history in Taiwan. In order to describe the creativity in their way of dealing with ruptures, of transforming the separation into the renovation of tradition, the author analyses their efforts in terms of geo-philosophy, through the lens of two concepts, dissemination and reterritorialization, that are borrowed from Jacques Derrida, Gilles Deleuze, and Felix Guattari.
Thomé Fang’s Pursuit of a Cultural Ideal
Authors: Wang Keping
Published: September 2020

Thomé Fang’s philosophical ideas are largely directed to the possibility of a form of humane enculturation that is somewhat similar to the Greek idea of paideia. His persistent pursuit of a cultural ideal is based on the rediscovery of and reflection on the relevance of Chinese and Western heritage, and a comparison of both. As an illustration of the cultural ideal that is the focus of his concern, it is conducive to examine the pagoda allegory that implies an approach to transcultural transformation or synthesis. In practice, this involves a threefold strategy and a reconsideration of cultural origins through artistic features.
Modern and Contemporary Taiwanese Philosophy
Authors: Rošker Jana S.
Published: September 2020

The topic of this special issue deals with the development of a certain stream of the Chinese philosophical tradition. Yet this philosophy did not originate in mainland China, and thus in some supposedly logical “centre” of Chinese culture, but on its alleged “periphery”, namely on the beautiful island of Taiwan. One of the incentives for our decision to compile an issue of Asian Studies which is devoted entirely to the philosophical developments in Taiwan was an international conference, entitled Taiwanese Philosophy and the Preservation of the Confucian Tradition. This interesting academic meeting was organized in October 2019 in Ljubljana by the Center for Chinese Studies at the National Central Library in Taiwan in cooperation with the East Asian Research Library (EARL) and the Department of Asian Studies at University of Ljubljana.
Kritik der Perspektive
Authors: Laleg Dominique
Published: September 2020

Die Linearperspektive ist in der künstlerischen Bildproduktion über Jahrhunderte ein wirkmächtiges Paradigma, bis sie in eine Krise gerät. Denn die ästhetische Moderne attackiert das hegemoniale Modell der perspektivischen Formgebung und macht die Perspektive zu einem Objekt der Kritik, von der angenommen wurde, dass sie Perspektivität überwinde. Anhand philosophischer Schlüsseltexte und mit Blick auf ausgewählte Werke von Rebecca H. Quaytman, Walid Raad, Bruce Nauman, Alberto Giacometti und Marcel Duchamp, entwickelt Dominique Laleg einen Begriff der Perspektive, welcher dem modernen Narrativ von deren Ende widerspricht. Denn gerade in der Kritik der Perspektive zeigt sich ihre Konjunktur als Modell, das sowohl in der modernen Theoriebildung als auch in der künstlerischen Praxis zum Tragen kommt. Laleg zeigt, wie die moderne Geschichte der Perspektive in den wirksamen Transformationen ihrer Form sowie der damit konstituierten Subjektivität besteht. Die moderne Kritik der Perspektive muss als Kritik mit den Mitteln der Perspektive selbst begriffen werden, denn Selbstkritik bildet den Knotenpunkt von Perspektive und Moderne.
A Resolução de Problemas na formação inicial: compreensões de futuros professores de Matemática
Authors: Bicalho Jossara Bazílio de Souza , Allevato Norma Suely Gomes , Silva José Fernandes da
Published: September 2020

Neste artigo, descrevemos uma pesquisa realizada a partir da aplicação de um questionário com 15 perguntas a um grupo de 17 estudantes de licenciatura em Matemática do Instituto Federal de Minas Gerais (IFMG), campus São João Evangelista, matriculados na disciplina Resolução de Problemas, do núcleo Práticas como Componente Curricular (PCC). Nosso objetivo foi levantar suas compreensões individuais acerca do potencial de inovação metodológica do ensino-aprendizagem-avaliação de Matemática através da resolução de problemas. Trata-se de uma pesquisa qualitativa, cuja análise de dados foi realizada a partir dos pressupostos da Análise Textual Discursiva (ATD). Os referencias teóricos perpassaram pela Resolução de Problemas, enquanto metodologia de ensino, e pela abordagem dos Conhecimentos do Professor de Matemática. Os futuros professores perceberam as habilidades que podem ser desenvolvidas pela Resolução de Problemas, enquanto ação e metodologia. Dessa forma, ficou evidente que a inovação metodológica no ensino de Matemática acontece quando a perspectiva da Resolução de Problemas é adotada.
Palavras-chave: Resolução de Problemas. Formação de Professores de Matemática. Conhecimentos do Professor de Matemática.
ARSITEKTUR RUMAH ADAT TRADISIONAL MBATANGU DI KAMPUNG RATENGGARO
Authors: Winne Sopiah Bela , Wiriantari Frysa
Published: September 2020

Traditional Sumba houses not only have meaning arising from the belief system, but also have technical solutions that are able to solve architectural problems arising from the shape of the building. The Mbatangu traditional house in Ratenggaro village, known as the tower house, is divided into 3 parts, namely the lower part (kali kambunga), the middle part or (uma dei), and the upper part (uma deta). These three parts have an integrated structural system from the foundation to the roof structure system so that this traditional house can stand in a unique shape and become part of the cultural heritage of the people of Southwest Sumba. Especially the Mbatangu traditional house on the coast, which has a roof which is much higher than other traditional houses in mountainous areas.
Transurethral fragmentation of bladder stone in children: Our experience
Authors: Zafar Ghulam Mujtaba , Javed Naseem , Humayun Fawad , Iqbal Asif
Published: September 2020

Background: This study is performed to find the outcome of transurethral fragmentation and clearance of bladder stones in children as well as assessment of stone recurrence after the procedure.
Methods: It was a retrospective analysis of the medical record of 365 patients with bladder stones, treated with transurethral fragmentation at the Department of Pediatric Urology, The Children’s Hospital and the Institute of Child Health, Lahore, over a period of 5 years. Bladder stones were fragmented by using ureterorenoscope (URS) and pneumatic Lithotripsy under general anesthesia. Patients were asked to void next day for spontaneous passage of stone fragments. Duration of procedure, hospital stay, peroperative, and postoperative complications were recorded on a self-structured proforma. The collected data was analyzed with SPSS, version 22.
Results: The mean age of the patients was 4.7 ±2.31 years, and male to female ratio was 6:1. Clinical presentation was painful micturition with milking of penis (55%), followed by straining during micturition (17.5%), urinary retention (10%), increased frequency of urine (8%), febrile UTI (7.5%), and hematuria (2%). The mean stone size on ultrasound was 17.2 ±3.8 mm (Range 7-25 mm). The average operating time was 18 minutes (Range: 12-35 minutes). The transurethral fragmentation was successfully done in all (100%) patients. Average hospital stay was 24 hours. Most patients (98.5%) passed all stone fragments in urine & were stone free at one week, confirmed by ultrasound and X-Ray Kidney, Ureter, and Bladder (KUB). Postoperative minor complications were found in (6%) patients including hematuria (3%), dysuria (2%), febrile UTI (1%), failure to void (0.5%). Stone recurrence was 0.27% and no urethral stricture was noted up to one year follow up.
Conclusion: Endoscopic treatment of bladder stone in children appears effective and safe by fragmenting the stone into multiple small pieces, which passed out spontaneously without any need for extraction of stone. The associated complications and recurrence rate are very negligible.
An alternative Laplace distribution
Authors: Kumar C. Satheesh , Jose Rosmi
Published: September 2020

In this paper, we propose an alternative version to the Laplace distribution which we named as “alternative Laplace distribution (ALD)” and discuss some of its important properties. A location-scale extension of the ALD is considered and the maximum likelihood estimation procedures for estimating its parameters is described. Further, the distribution is ﬁtted to certain real life data sets for illustrating the utility of the model. A simulation study is carried out to examine the performance of likelihood estimators of the parameters of the distribution.
PERINGKAS TEKS OTOMATIS DOKUEM TUNGGAL DAN MULTI BAHASA MENGGUNAKAN METODE TF-IDF
Authors: Abidin Aa Zezen Zaenal , Rayi A Eka Yuda
Published: September 2020

Sistem peringkas teks otomatis berita kesehatan multi bahasa dapat digunakan oleh pembaca untuk meringkas teks berita kesehatan berbagi terjemahanya untuk kebutuhan berbagai jenis kegiatan. Untuk mengembangkan perangkat lunak yang sesuai dan mudah dimengerti untuk pengguna dalam membaca berita dan menterjemahkannya dalam bahasa internasional. Berita kesehatan dilakukan proses teks diproses hapus tanda baca, stopword, stemming, tokenizing, pembobotan kata dan pembobotan kalimat. Setelah pemrosesan teks setiap kalimat akan memiliki bobot masing-masing dari yang bernilai hingga terendah. K8 mendapatkan bobot 37.19723289, K9 mendapatkan bobot 17.89999416, K10 mendapatkan bobot 16.52464106 dan K3 mendapatkan bobot 14.77709596. metode yang digunakan adalah Metode Term frequency inverse document frequency (TF-IDF). Sistem menerima entri berita, menterjemahkan, dokumen menjadi kalimat, membuang karakter, memecahkanya menjadi kata, memberikan nilai bobot pada kata, menjumlahkan nilai bobot, menghitung nilai idf dan TD-IDF sehingga dapat memperoleh nilai bobot dari setiap kalimat yang akan menghasilkan nilai paling tinggi. Bahasa pemrograman yang digunakan adalah PHP dan DBMS menggunakan MySQL. Editor menggunakan Sublime dan Tools menggunakan Xampp 3.2.2 Sistem peringkas teks berita kesehatan multi-bahasa otomatis tidak perlu menyita waktu yang cukup lama untuk membaca dan menerjemahkan. Sistem peringkas teks berita kesehatan dengan cara menguji pembobotan kalimat manual dan otomatis dengan hasil penilaian yang sama dan sistem ini dapat memahami isi berita penting yang diinputkan, dengan memiliki verifikasi pengujian responden 54,17%.
Bagaimana Mengukur Efektifitas Co-Branding Wonderful Indonesia: Studi Konseptual
Authors: Hakim Imam Nur
Published: September 2020

Kementerian Pariwisata, melalui program Wonderful Indonesia (WI), memutuskan untuk menggunakan peningkatan Country Brand Ranking (edisi pariwisata) pada 2015 sebagai momentum untuk menerbitkan kebijakan co-branding. Sekarang, kolaborasi ini telah melibatkan 172 mitra dari 14 kategori perusahaan. Seharusnya, kolaborasi ini dapat meningkatkan ekuitas merek WI dan berdampak pada perluasan jangkauan pasar, peningkatan kesadaran, dan menunjukkan citra merek yang lebih positif. Namun, peringkat merek WI terus kalah dari pesaing utamanya. Oleh karena itu perlu dilakukan langkah evaluatif terkait efektivitas kerja sama co-branding. Penelitian ini menggunakan pendekatan deskriptif kualitatif dan yang secara konseptual mengungkapkan beberapa pilihan metode dalam mengukur efektivitas co-branding WI dari perspektif wisatawan. Hasil penelitian ini menemukan bahwa pilihan kesadaran merek, citra merek, sikap terhadap merek, niat beli, dan kekuatan elemen pembentuk co-branding dapat menjadi alat ukur untuk menentukan sejauh mana kolaborasi ini dianggap efektif.
Pariwisata Berbasis Alam: Memahami Perilaku Wisatawan
Authors: Novianti Evi , Larasati Ajeng Ramadhita , Asy'ari Rifqi , Pribadi Teguh Imam , Sariadi Sarmoko , Hadian Mohammad Sapari Dwi , Wulung Shandra Rama Panji
Published: September 2020

Tujuan dari penelitian ini adalah memahami perilaku wisatawan dalam fungsi interaksi di suatu destinasi pariwisata khususnya kepariwisataan di Indonesia dengan menggunakan metode bibliometric study atau dengan metode penelitian dari data sekunder. Hasil dari penelitian ini menunjukkan bahwa interpretasi yang baik akan sangat mempengaruhi suatu destinasi dan calon wisatawan yang akan mengunjunginya. Semakin tinggi nilai tambah suatu destinasi  yang ditawarkan kemudian ditambah interpretasi yang baik maka semakin menarik calon wisatawan untuk melakukan perjalanan, khususnya Nature-Based Tourismyang sejatinya memiliki banyak hal untuk dipelajari oleh wisatawan.
Hubungan Jumlah Kunjungan Wisatawan Mancanegara dengan Rata-Rata Tingkat Penghunian Kamar Hotel Provinsi DKI Jakarta Tahun 2012—2018
Authors: Suwanto Suwanto
Published: September 2020

Penelitian ini membahas masalah hubungan jumlah kunjungan wisatawan mancanegara dengan rata-rata tingkat penghunian kamar hotel Provinsi DKI Jakarta. Riset ini dilakukan untuk menganalisis hubungan jumlah kunjungan wisatawan mancanegara dengan rata-rata tingkat penghunian kamar hotel Provinsi DKI Jakarta. Penelitian kuantitatif ini menggunakan sumber data sekunder dan jenis data times series dengan skala ratio. Data jumlah kunjungan wisatawan mancanegara dan data rata-rata tingkat penghunian kamar hotel Provinsi DKI Jakarta tahun 2012—2018 diperoleh dari Badan Pusat Statistik Provinsi DKI Jakarta dalam bentuk data bulanan. Pengolahan dan analisis data menggunakan teknik korelasi Pearson. Analisis temuan penelitian menunjukkan bahwa terdapat hubungan yang kuat, dan arah hubungan yang searah (positif) antara jumlah kunjungan wisatawan mancanegara dengan rata-rata tingkat penghunian kamar hotel Provinsi DKI Jakarta. Terdapat kecenderungan jika jumlah kunjungan wisatawan mancanegara naik maka rata-rata tingkat penghunian kamar hotel juga naik, begitu pula sebaliknya.  Rekomendasi yang dapat disampaikan adalah memperhatikan faktor-faktor yang relevan selain jumlah kunjungan wisatawan mancanegara, seperti jumlah kunjungan wisatawan nusantara dari berbagai daerah di Indonesia, daya tarik wisata, aksesibilitas tempat wisata, serta keamanan dan kenyamanan wisatawan dalam pengembangan usaha di bidang perhotelan sebagai upaya untuk menaikkan rata-rata tingkat penghunian kamar hotel.
Propuesta didáctica de una maqueta interactiva para explicar el comportamiento de las líneas de transmisión de energía eléctrica
Authors: Llamo-Laborí Héctor Silvio , Santos-Fuentefria Ariel , Pérez-Martínez Maykop
Published: September 2020

La nueva transformación curricular llevada a cabo en la carrera de Ingeniería Eléctrica, responde a las demandas a nivel internacional y nacional para un egresado de esta carrera, es por ello que la cuestión principal sigue siendo, probablemente, bajo qué concepción y con qué procedimientos realizar los cambios fundamentales para desarrollar un proceso docente educativo comunicativo, independiente y creador, se tomó como ejemplo la asignatura de Sistemas Eléctricos I que se imparte en el primer semestre del cuarto año de la carrera de Ingeniería Eléctrica, que se cursa en la Universidad Tecnológica de la Habana CUJAE. El objetivo de este trabajo es, a partir de la utilización de una maqueta que modele el comportamiento de las líneas de transmisión, caracterizar, el objetivo del proceso enseñanza- aprendizaje como uno de los componentes del proceso, desde una dimensión comunicativa, de manera que el tratamiento didáctico del mismo propicie en la práctica, una interrelación entre profesores y alumnos y alumnos entre sí y permita la implicación del alumno en su propio proceso de aprendizaje, para ello, la presente propuesta didáctica considera, en el marco general del aprendizaje activo, la actividad experimental en la clase como una herramienta de trabajo sistemática y organizada, donde es necesario articular el uso metodológico de la clase-laboratorio para enriquecer el proceso de enseñanza-aprendizaje y la construcción del conocimiento.
Educar la mirada científica del alumnado de secundaria en el marco de los objetivos del desarrollo sostenible, educar para una ciudadanía global en un momento de cambio educativo
Authors: Menoyo Díaz María del Pilar
Published: September 2020

La situación de emergencia sanitaria por la irrupción en nuestras vidas de la COVID19, ha trasformado de golpe nuestra forma de vivir. Ante estos nuevos problemas globales, tanto personas expertas como particulares de todas las edades, niveles educativos y contextos han tratado de idear respuestas variadas con un común denominador: la utilización de medios masivos de comunicación y espacios virtuales. Ello ha iniciado un cambio digital, con vises de no tener marcha atrás, en la manera en que se interconectan las personas, un cambio que también se ha producido en los centros escolares. Paralelamente, la COVID19 ha evidenciado la importancia del conocimiento científico para abordar adecuadamente estos nuevos retos: asumir y gestionar la incertidumbre, hacerse las preguntas adecuadas, tomar decisiones basadas en datos, distinguir lo anecdótico de lo relevante... son algunas de las competencias propias de la investigación que han resultado clave en este contexto. Es por ello que el alumnado de secundaria no puede ser ajeno a ellas. Así pues, el profesorado deberá ser guía para dotar al alumnado de competencias propias de la investigación. Para ello deberá enseñar a formular preguntas, a plantear objetivos e hipótesis, a seguir una metodología, a utilizar herramientas para la obtención y análisis de datos, así como a divulgar los resultados y, especialmente, a utilizar la evaluación como guía de todo el proceso. En el presente artículo, mostramos una manera organizativa de diseñar un curso Moodle para alumnos desde 1º de ESO hasta Bachillerato, orientado a enseñar y aprender a investigar, teniendo como marco de actuación los Objetivos del Desarrollo Sostenible. Dos son las principales contribuciones de este planteamiento, especialmente relevantes en el escenario descrito: la primera es que posibilita una educación híbrida, presencial y online. La segunda es que favorece la acción transformadora del mundo, en el que los y las adolescentes son y tienen que ser protagonistas, ciudadanos activos que respondan a sus propias preguntas y que contribuyan así a que nuestro mundo sea un lugar donde vivir todos mejor.
Formación del profesorado en modelización: primeros pasos de una profesora novel
Authors: Mata Codes Paz , Gallart Palau César
Published: September 2020

Ante la mayor demanda de actividades que conecten las matemáticas con el mundo real, el curso de formación para el profesorado, ‘Setmana de la modelització’, nace con el objetivo de dotar a los profesores de secundaria y bachillerato de los conocimientos y las herramientas que faciliten la introducción de la modelización matemática en sus aulas. En el presente artículo se describe este curso de formación, objetivos y contenidos, y sus resultados se ilustran a través de la descripción de la experiencia de una de sus participantes. Esta experiencia incide en tres aspectos: el diseño de la tarea de modelización, la implementación de la actividad en el aula y la evaluación. Por último, se exponen las reflexiones y conclusiones a las que se han llegado al implementar la actividad, cómo se han superado las dudas iniciales respecto a la misma y sus implicaciones respecto al propio proceso de enseñanza-aprendizaje y el diseño del curso de formación.
Diagnosis and Management of Fatty Liver
Authors: Tan Phei Oon , Mustaffa Nazri , Tan Soek Siam , Lee Yeong Yeh
Published: September 2020

Globally, the prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing rapidly and constitutes a significant healthcare burden due to associated complications including hepatic (cirrhosis and hepatocellular cancer) and non-hepatic (cardiovascular deaths) disorders. It is closely linked to insulin resistance and metabolic syndrome but moderate alcohol consumption frequently coexists. Recently, genetic polymorphisms were implicated in the development of non-obese NAFLD. Apart from liver biopsy, in order to assess for steatosis, fibrosis and non-alcoholic steatohepatitis (NASH), advances in non-invasive serum tests and elastography have provided similarly accurate, more accessible and safer alternatives for risk stratification. As for treatment in 2020, weight loss and lifestyle modification remain the central strategy. Unfortunately, no pharmacological agents have been approved thus far, but there are a number of potential therapies in the pipeline for fibrosis and NASH. Treatment of underlying metabolic disorders is important. While the term NAFLD was coined in the 1980s, more recent understanding may support a change in nomenclature highlighting its strong metabolic roots.
Diabetic Autonomic Neuropathy: A Clinical Update
Authors: Sharma Jugal Kishor , Rohatgi Anshu , Sharma Dinesh
Published: September 2020

Diabetic autonomic neuropathy is an under-recognised complication of diabetes and the prediabetic state. A wide range of manifestations can be seen due to involvement of cardiovascular, gastrointestinal, genitourinary, sudomotor and neuroendocrine systems. Cardiac autonomic neuropathy is the most dreaded complication carrying significant mortality and morbidity. Early detection and control of diabetes and other cardiovascular risk factors is the key to treat and prevent progression of autonomic neuropathy. Recently, a new entity of treatment-induced neuropathy (TIND) of diabetes mellitus causing autonomic neuropathy is being increasingly recognised.
Progressive Ataxia and Cognitive Decline in a 67-Year-Old Male: A Diagnostic Challenge
Authors: Osman Dina , Weidner Alice , Madhra Mayuri
Published: September 2020

We report the case of a 67-year-old male who presented with a six-week history of progressive unsteadiness, cognitive impairment and weight loss, in the context of a recent bereavement. Magnetic resonance imaging (MRI) performed several weeks earlier excluded acute stroke.

Examination revealed gross bilateral ataxia, bradyphrenia and physical manifestations of depression. Collateral history suggested rapidly progressing symptoms over three months. Repeat MRI head showed features suggestive of Creutzfeldt-Jakob disease (CJD) including T2 hyperintensities in the basal ganglia. Cerebrospinal fluid (CSF) samples were positive for 14-3-3 protein, S100b and real-time quaking-induced conversion (RT-QuIC) proteins confirming the diagnosis of sporadic CJD (sCJD).
A Patient with Atrioventricular Block and Ventricular Tachycardia: Think Sarcoid!
Authors: Majumdar Suchit , Chatterjee Arindam , Banerjee Suvro
Published: September 2020

Cardiac involvement in sarcoidosis is often difficult to diagnose, and most alarmingly can lead to sudden cardiac arrest as its first manifestation. We report the case of a 45-year-old Indian woman with an implanted permanent pacemaker for atrioventricular block, who presented with haemodynamically stable ventricular tachycardia and was found to have impaired left ventricular function. Subsequent investigations established the diagnosis of cardiac sarcoidosis. The patient was treated with prednisolone initially at 40 mg a day for 3 months. Left ventricular function improved over 3 months of treatment and there was no further recurrence of ventricular tachycardia. Screening for cardiac sarcoidosis should be considered in a patient with unexplained atrioventricular block and ventricular tachycardia, particularly if young, even in the absence of clinical findings of extracardiac sarcoidosis. Treatment of the cardiac sarcoidosis could control ventricular tachycardia and improve left ventricular function.
Hypophysitis in Granulomatosis with Polyangiitis: Rare Presentation of a Multisystem Disease
Authors: Ramakrishna Manjunath P , Arun Chankramath S , Pavithran Praveen V , Bhagavaldas Mithun C , Kumar Harish
Published: September 2020

Granulomatosis with polyangiitis (GPA) is a type of granulomatous vasculitis that can involve any organ in the body. The pituitary gland is one of the uncommon sites to be involved in this condition, with only a few cases reported in the literature. Our patient initially presented with central diabetes insipidus, epistaxis and haematuria. Diagnosis was established by antineutrophil cytoplasmic antibodies (cANCA) positivity against a background of typical clinical features and a bulky pituitary on magnetic resonance imaging (MRI) scan. Patient was started on steroids and methotrexate which were later changed to mycophenolate mofetil due to intolerance. Due to the refractory nature of the disease the patient was treated with one course of rituximab. Since then she has not had epistaxis, joint pains or haematuria. She continues to have diabetes insipidus although the requirement of desmopressin has come down. We thus report a case of GPA with hypophysitis which is one of the rare manifestations of the disease.
Corrosionâresistant materials for alkaline water electrolyzers
Authors: Sequeira CÃ©sar , Cardoso David , Amaral LuÃ­s , Sljukic Biljana , Santos Diogo
Published: September 2020

Commercially available materials for fabricating cell bodies, electrodes, pipes, and pumps for alkaline water electrolyzers, include conventional steels and stainless steels, nickel, valve metals, polymers, and other materials. In this review paper, most of these construction materials are briefly described and discussed. Special attention is given to presently produced nickel electrodes and novel nickel-based electrocatalysts for the hydrogen and oxygen evolution reactions in alkaline water electrolysis. It is shown that their electrocatalytic activity and corrosion resistance need to be improved in order to increase their commercial interest for alkaline water electrolyzers.