bluuebunny/crossref_metadata_2025 huggingface dataset:
Structural analysis of type 3 resistant starch from Canna edulis during in vitro simulated digestion and its post-digested residue impact on human gut microbiota
Authors: Tang Leimengyuan , Wu Jiahui , Aga Lvbu , Wang Nan , Li Yan , Li Houxier , Wang Xueyong
Published: June 2024

Introduction

Resistant starch (RS) has garnered attention for its health benefits, including modulating the gut microbiota and promoting the production of short-chain fatty acids (SCFAs).

Methods

This study investigates structural changes of type 3 resistant starch from Canna edulis (CE) during in vitro simulated digestion and explores its health-relevant properties using healthy individuals’ fecal microbiota.

Results

CE, prepared with a RS content of 59.38%, underwent a comprehensive analysis employing X-ray diffraction (XRD), fourier-transform infrared spectroscopy (FTIR), and scanning electron microscopy (SEM). During simulated digestion, XRD analysis demonstrated a significant rise in CE’s relative crystallinity from 38.92 to 49.34%. SEM illustrated the transition of CE from a smooth to a rough surface, a notable morphological shift. Post-digestion, CE was introduced into microbial fermentation. Notably, propionic acid and valeric acid levels significantly increased compared to the control group. Furthere more, beneficial Bifidobacterium proliferated while pathogenic Escherichia-Shigella was suppressed. When comparing CE to the well-known functional food fructo-oligosaccharide (FOS), CE showed a specific ability to support the growth of Bifidobacterium and stimulate the production of short-chain fatty acids (SCFAs) without causing lactic acid accumulation.

Discussion

CE demonstrates potential as a functional health food, with implications for gut health enhancement and SCFAs production.
Desmoplastic small round cell tumor of the kidney: a case report and discussion
Authors: Huang Guizhen , Huang Wenqian , Liu Mingxue
Published: June 2024

A 13-year-old boy was admitted to the hospital with 1-month history of neck pain and a 2-week history of bilateral hip joint pain accompanied by low fever. Positron emission tomography-computed tomography (PET-CT) revealed the presence of a malignant tumor in the left kidney with metastases to the left renal hilum, retroperitoneum, para-aortic lymph nodes, and multiple bone sites throughout the body. Given that the patient’s left kidney capsule was intact and the boundary with surrounding tissues was clear, left nephrectomy was performed. Postoperative pathological diagnosis showed desmoplastic small round cell tumor (DSRCT) of the left kidney. CAV-VIP alternating chemotherapy was given 20 days after the first stage surgery. After the end of the 6th cycle, the patient underwent surgery again. The tumor in front of the aorta and postcava, the greater omentum, the retroperitoneal lymph nodes and the hepatic hilum lymph nodes, and the visible tumors in the abdomen were removed. CAV-VIP alternating chemotherapy was continued after the second stage surgery. At the end of the 4th cycle of post operation chemotherapy, radiotherapy was started. An abdominal CT scan conducted 11 months after second-stage surgery did not reveal any recurrence of abdominal tumors; however bone metastases persisted. The patient is currently receiving oral targeted therapy with anlotinib while ongoing follow-up continues.
Case report: The diagnostic pitfall of Warthin-like mucoepidermoid carcinoma
Authors: Yang Ying , Lei Zi , Lang Yixu , Wu Li , Hu Jun , Liu Shiyue , Hu Zaoxiu , Pan Guoqing
Published: June 2024

Warthin-like mucoepidermoid carcinoma (WL-MEC) is a newly reported variant of mucoepidermoid carcinoma. Its histological feature is easy to confused with metaplastic Warthin Tumor, and its relationship with Warthin tumor in histogenesis is controversial. In this study, we presented two cases of WL-MEC, discussing their clinicopathological and molecular features. Notably, one case was initially misdiagnosed during the first onset of the tumor. Case 1 was a 60-year-old female with a mass in the right parotid gland. Case 2 featured a 29-year-old male who developed a lump at the original surgical site 6 months after a “Warthin tumor” resection from the submandibular gland. Histologically, both tumor exhibited a prominent lymphoid stroma and cystic pattern, accompanied by various amounts of epithelial nests composed of squamoid cells, intermediate cells and mucinous cells. The characteristic eosinophilic bilayer epithelium of Warthin tumor was not typically presented in either case. Both cases tested positive for MAML2 gene rearrangement. To contextualize our findings, we conducted a comprehensive review of forty-eight WL-MEC cases documented in the English literature, aiming to synthesizing a reliable differential diagnostic approach. WL-MEC is a rare yet clinically relevant variant, posing a diagnostic pitfall for pathologists. Our study underscores the importance of a meticulous evaluation of both clinical and histological features, coupled with the detection of MAML2 rearrangement, as a credible method for distinguishing WL-MEC from other benign and malignant lesions, particularly metaplastic Warthin tumor.
Ultrasonographic and clinicopathological features of pelvic yolk sac tumors in women: a single-center retrospective analysis
Authors: Chen Mei , Zhang Shengmin , Jia Xiupeng , Xu Youfeng , Wei Yaping , Liao Shusheng
Published: June 2024

Objectives

Yolk sac tumors (YSTs) are rare and highly malignant ovarian malignancies that have a very poor prognosis. The aim of this study is to delineate the ultrasound and clinicopathological features of female pelvic YSTs to better understand the disease.

Methods

This study was a retrospective analysis of the clinicopathological and ultrasound imaging data from 16 YST patients who received treatment at our hospital between January 2012 and August 2023. Then, the ultrasound imaging characteristics were compared with pathological findings.

Results

Among the 16 patients, various degrees of serum AFP increase were observed, and CA125 levels increased in 58.33% (7 out of 12) of patients. Thirteen patients (81.25%) had tumors located in ovary, two patients (12.5%) had tumors located in the sacrococcygeal region, and one patient (6.25%) had tumors located in the mesentery. Pathologically, nine patients presented with simple yolk sac tumors and seven with mixed germ cell tumors. According to the ultrasound manifestations, YST lesions can be classified into three types. (1) the cystic type, was diagnosed in two patients who presented with a large cystic mass with regular morphology and clear boundary and dense liquid within the cyst; and (2) the cystic-solid mixed type, was diagnosed in 4 patients. On 2D ultrasound, the lesions showed a cystic-solid mixed echo, and color Doppler showed a rich blood flow signal in the solid region and cystic separation. made up of four cases. (3) In ten patients with the solid type, 2D ultrasound showed solid uniform echoes with clear boundaries. The “fissure sign” was observed in the lesion. Color Doppler displayed rich blood flow in the solid part, and PW showed low to moderate resistance index of artery (RI:0.21–0.63). On contrast-enhanced ultrasound (CEUS), rapid and high enhancement in the solid part and cystic separation was observed in 2 patients.

Conclusions

Combining ultrasound features with clinical information and tumor markers provides reliable clues for the diagnosis of YST. The application of two-dimensional ultrasound and CEUS combined with patient tumor marker levels can provide a robust reference for determining the necessity of fertility-preserving surgery and postoperative chemotherapy, which can improve clinical decision-making and patient consultation.
The search for blood biomarkers that indicate risk of adverse neurodevelopmental outcomes in fetal growth restriction
Authors: Musco Hannah , Beecher Kate , Chand Kirat K. , Boyd Roslyn N. , Colditz Paul B. , Wixey Julie A.
Published: June 2024

Fetal growth restriction (FGR) impacts 5%–10% of pregnancies and is associated with increased risk of mortality and morbidity. Although adverse neurodevelopmental outcomes are observed in up to 50% of FGR infants, a diagnosis of FGR does not indicate the level of risk for an individual infant and these infants are not routinely followed up to assess neurodevelopmental outcomes. Identifying FGR infants at increased risk of adverse neurodevelopmental outcomes would greatly assist in providing appropriate support and interventions earlier, resulting in improved outcomes. However, current methods to detect brain injury around the time of birth lack the sensitivity required to detect the more subtle alterations associated with FGR. Blood biomarkers have this potential. This systematic review assessed the current literature on blood biomarkers for identifying FGR infants at increased risk of adverse neurodevelopmental outcomes at >12 months after birth. Four databases were searched from inception to 22 February 2024. Articles were assessed for meeting the inclusion criteria by two reviewers. The quality of the included article was assessed using Quality Assessment of Diagnostic Accuracy Studies-2. A summary of findings is presented as insufficient articles were identified for meta-analysis. Excluding duplicates, 1,368 records were screened with only 9 articles considered for full text review. Only one article met all the inclusion criteria. Quality assessment indicated low risk of bias. Both blood biomarkers investigated in this study, neuron specific enolase and S100B, demonstrated inverse relationships with neurodevelopmental assessments at 2 years. Four studies did not meet all the inclusion criteria yet identified promising findings for metabolites and cytokines which are discussed here. These findings support the need for further research and highlight the potential for blood biomarkers to predict adverse outcomes.

Systematic Review Registration

https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=369242, Identifier CRD42022369242.
Effect of ultrashort-acting β-blockers on 28-day mortality in patients with sepsis with persistent tachycardia despite initial resuscitation: a meta-analysis of randomized controlled trials and trial sequential analysis
Authors: Huang Po , Liu Fusheng , Hu Xiao , Li Bo , Xu Xiaolong , Liu Qingquan
Published: June 2024

Purpose

This meta-analysis aims to identify whether patients with sepsis who have persistent tachycardia despite initial resuscitation can benefit from ultrashort-acting β-blockers.

Materials and methods

Relevant studies from MEDLINE, the Cochrane Library, and Embase were searched by two independent investigators. RevMan version 5.3 (Cochrane Collaboration) was used for statistical analysis.

Results

A total of 10 studies were identified and incorporated into the meta-analysis. The results showed that the administration of ultrashort-acting β-blockers (esmolol/landiolol) in patients with sepsis with persistent tachycardia despite initial resuscitation was significantly associated with a lower 28-day mortality rate (risk ratio [RR], 0.73; 95% confidence interval [CI], 0.57–0.93; and p˂0.01). Subgroup analysis showed that the administration of esmolol in patients with sepsis was significantly associated with a lower 28-day mortality rate (RR, 0.68; 95% CI, 0.55–0.84; and p˂0.001), while there was no significant difference between the landiolol and control groups (RR, 0.98; 95% CI, 0.41–2.34; and p = 0.96). No significant differences between the two groups were found in 90-day mortality, mean arterial pressure (MAP), lactate (Lac) level, cardiac index (CI), and troponin I (TnI) at 24 h after enrollment.

Conclusion

The meta-analysis indicated that the use of esmolol in patients with persistent tachycardia, despite initial resuscitation, was linked to a notable reduction in 28-day mortality rates. Therefore, this study advocates for the consideration of esmolol in the treatment of sepsis in cases where tachycardia persists despite initial resuscitation.
Evaluating myelophil, a 30% ethanol extract of Astragalus membranaceus and Salvia miltiorrhiza, for alleviating fatigue in long COVID: a real-world observational study
Authors: Joung Jin-Yong , Lee Jin-Seok , Choi Yujin , Kim Yoon Jung , Oh Hyeon-Muk , Seo Hyun-Sik , Son Chang-Gue
Published: June 2024

Background

Persistent post-infectious symptoms, predominantly fatigue, characterize Long COVID. This study investigated the efficacy of Myelophil (MYP), which contains metabolites extracted from Astragalus membranaceus and Salvia miltiorrhiza using 30% ethanol, in alleviating fatigue among subjects with Long COVID.

Methods

In this prospective observational study, we enrolled subjects with significant fatigue related to Long COVID, using criteria of scores of 60 or higher on the modified Korean Chalder Fatigue scale (mKCFQ11), or five or higher on the Visual Analog Scale (VAS) for brain fog. Utilizing a single-arm design, participants were orally administered MYP (2,000 mg daily) for 4 weeks. Changes in fatigue severity were assessed using mKCFQ11, Multidimensional Fatigue Inventory (MFI-20), and VAS for fatigue and brain fog. In addition, changes in quality of life using the short form 12 (SF-12) were also assessed along with plasma cortisol levels.

Results

A total of 50 participants (18 males, 32 females) were enrolled; 49 were included in the intention-to-treat analysis with scores of 66.9 ± 11.7 on mKCFQ11 and 6.3 ± 1.5 on the brain fog VAS. After 4 weeks of MYP administration, there were statistically significant improvements in fatigue levels: mKCFQ11 was measured at 34.8 ± 17.1 and brain fog VAS at 3.0 ± 1.9. Additionally, MFI-20 decreased from 64.8 ± 9.8 to 49.3 ± 10.8, fatigue VAS dropped from 7.4 ± 1.0 to 3.4 ± 1.7, SF-12 scores rose from 53.3 ± 14.9 to 78.6 ± 14.3, and plasma cortisol levels also elevated from 138.8 ± 50.1 to 176.9 ± 62.0 /mL. No safety concerns emerged during the trial.

Conclusion

Current findings underline MYP’s potential in managing Long COVID-induced fatigue. However, comprehensive studies remain imperative.

Clinical Trial Registration

https://cris.nih.go.kr, identifier KCT0008948.
Shenfu injection improves isoproterenol-induced heart failure in rats by modulating co-metabolism and regulating the trimethylamine-N-oxide - inflammation axis
Authors: Li Lin , Ye Jiahao , Zhao Zhenyu , Hu Siyuan , Liang Hao , Ouyang Ji , Hu Zhixi
Published: June 2024

Heart failure (HF) is a chronic condition that progressively worsens and continues to be a major financial burden and public health concern. The “gut-heart” axis provides an innovative perspective and therapeutic strategy for preventing and treating heart failure. Shenfu injection (SFI) is a Traditional Chinese Medicine-based treatment demonstrating potential as a therapeutic strategy for heart failure. However, the precise therapeutic mechanisms of SFI in heart failure are not completely characterized. In this study, HF models were established utilizing subcutaneous multipoint injection of isoproterenol (ISO) at a dosage of 5 mg kg−1·d−1 for 7 days. Serum levels of inflammatory biomarkers were quantified using protein microarrays. Rat feces were analyzed using untargeted metabolomics research and 16S rRNA sequencing. The link between gut microbiota and metabolites was examined using a MetOrigin and Spearman correlation analysis. Our results show that Shenfu injection effectively enhances cardiac function in rats with ISO-induced heart failure by potentially modulating pro-/anti-inflammatory imbalance and reducing serum and urine Trimethylamine-N-oxide (TMAO) levels. Moreover, SFI significantly increases the abundance of Bacteroidota at the phylum level, thereby improving disrupted gut microbiota composition. Additionally, SFI supplementation enriches specific genera known for their capacity to produce short-chain fatty acids. SFI was found to be associated with three key metabolic pathways, as revealed by fecal metabonomics analysis, including the pentose phosphate pathway, pyrimidine metabolism, and purine metabolism. Metabolite tracing analysis revealed that Taurine and hypotaurine metabolism was found to be specific to the microbial community. The biosynthesis of Pyrimidine metabolism, Purine metabolism, beta-alanine metabolism, Naphthalene degradation, Pantothenate, and CoA biosynthesis were identified as co-metabolic pathways between microbes and host. The Spearman correlation analysis was also significantly correlated to differentially expressed metabolites regulated by SFI and the gut microbiota. These results suggest that SFI improves ISO-induced heart failure by modulating co-metabolism and regulating the TMAO-inflammation axis.
Spatial specificity of metabolism regulation of abscisic acid-imposed seed germination inhibition in Korean pine (Pinus koraiensis sieb et zucc)
Authors: Song Yuan , Li Xinghuan , Zhang Mingyi , Xiong Chao
Published: June 2024

Introduction

Abscisic acid (ABA) can negatively regulate seed germination, but the mechanisms of ABA-mediated metabolism modulation are not well understood. Moreover, it remains unclear whether metabolic pathways vary with the different tissue parts of the embryo, such as the radicle, hypocotyl and cotyledon.

Methods

In this report, we performed the first comprehensive metabolome analysis of the radicle and hypocotyl + cotyledon in Pinus koraiensis seeds in response to ABA treatment during germination.

Results and discussion

Metabolome profiling showed that following ABA treatment, 67 significantly differentially accumulated metabolites in the embryo were closely associated with pyrimidine metabolism, phenylalanine metabolism, cysteine and methionine metabolism, galactose metabolism, terpenoid backbone biosynthesis, and glutathione metabolism. Meanwhile, 62 metabolites in the hypocotyl + cotyledon were primarily involved in glycerophospholipid metabolism and glycolysis/gluconeogenesis. We can conclude that ABA may inhibit Korean pine seed germination primarily by disrupting the biosynthesis of certain plant hormones mediated by cysteine and methionine metabolism and terpenoid backbone biosynthesis, as well as reducing the reactive oxygen species scavenging ability regulated by glutathione metabolism and shikimate pathway in radicle. ABA may strongly disrupt the structure and function of cellular membranes due to alterations in glycerophospholipid metabolism, and weaken glycolysis/gluconeogenesis in the hypocotyl + cotyledon, both of which are major contributors to ABA-mediated inhibition of seed germination. These results highlight that the spatial modulation of metabolic pathways in Pinus koraiensis seeds underlies the germination response to ABA.
Mitigating aluminum toxicity and promoting plant resilience in acidic soil with Penicillium olsonii TLL1
Authors: Dhandapani Savitha , Sng Yee Hwui , Agisha Valiya Nadakkakath , Suraby Erinjery Jose , Park Bong Soo
Published: June 2024

Aluminum (Al), prevalent in the crust of the Earth, jeopardizes plant health in acidic soils, hindering root growth and overall development. In this study, we first analysed the Al- and pH- tolerance of the Penicillium olsonii TLL1 strain (POT1; NRRL:68252) and investigated the potential for enhancing plant resilience under Al-rich acidic soil conditions. Our research illustrates the extraordinary tolerance of POT1 to both high Al concentrations and acidic conditions, showcasing its potential to alleviate Al-induced stress in plants. Metabolite analysis revealed that POT1 detoxifies Al through organic acid-dependent chelation mechanisms, significantly reducing Al stress in Arabidopsis and Pak Choi plants. Consequently, plant growth conditions improved, and the Al content in plant tissues decreased. Transcriptome analysis indicated that POT1 treatment downregulates genes associated with Al and oxidative stress such as MATE, ALS3, NIP1–2 and several peroxidases, highlighting its effectiveness in lessening Al-induced damage. Comparative assessments highlight the superior performance of POT1 compared to other Al-tolerant Penicillium species, attributed to its ability to thrive in diverse pH levels and effectively detoxify Al. These findings position POT1 as a promising agent for enhancing crop resilience in Al-compromised acidic soils, offering new avenues for promoting plant health and bolstering food security through increased crop yield and safety.
The effects of EFL wordlist and proficiency on vocabulary knowledge
Authors: Bao Zhen , Peng Cheng
Published: June 2024

Introduction

The Gaokao Word List (GWL) in China serves as a guideline for learning L2 vocabulary, but there are few studies verifying its effect on university EFL learners’ vocabulary knowledge.

Method

This study investigated the effects of the GWL and EFL proficiency on 66 Chinese university EFL learners’ vocabulary knowledge by administering word recognition tests.

Results and discussion

The results showed that: (1) the GWL had significant effects on participants’ receptive vocabulary knowledge; (2) EFL proficiency had significant effects on participants’ word recognition, without interaction with the GWL. These findings were discussed through the lens of frequency of exposure, accounting for the overwhelming GWL effect on learners’ vocabulary knowledge. We suggest EFL proficiency be taken into consideration when the GWL is revised in the future, to smoothen the transition in vocabulary learning from high school to university, and improve vocabulary learning efficiency.
Facilitation or hindrance? The impact of downward social comparison on adversarial growth
Authors: Nie Ting , Wu Jing , Yan Qiao
Published: June 2024

Introduction

While adversity can bring great challenges to individuals' life and work, many people also find ways to make positive changes and adapt to these difficult circumstances. Individuals tend to make social comparisons more frequently and intensely when faced with adversity or high stress. The study attempts to examine the influence mechanism of downward social comparison on individual adversarial growth.

Methods

By collecting data from 353 Chinese who have experienced adversities in the past 3 years, the study validates the dual mediating model of gratitude and self-acceptance and explores the moderating effect of interpersonal sensitivity.

Results

The findings indicate that: downward social comparison can increase the occurrence of adversarial growth by enhancing individuals' self-acceptance and gratitude. Compared to individuals with low interpersonal sensitivity, individuals with high interpersonal sensitivity are more likely to facilitate the occurrence of adversarial growth through self-acceptance and gratitude due to downward social comparison.

Discussion

In the face of adversity, individuals can regain self-confidence and respond positively by comparing themselves to people in worse situations than themselves. In particular, individuals with higher interpersonal sensitivity are more likely to benefit from downward social comparisons and grow from adversity.
Enriching cross-sectoral collaboration to foster inclusive cultures in schools: a Model to address the needs of diverse Chilean Students
Authors: Vidal Veronica , Mendive Susana , Gómez Zaccarelli Florencia , Pozo-Tapia Francisca , Narea Marigen , Wachholtz Daniela , Melo Carolina
Published: June 2024

Inclusive education involves the interaction of diverse actors from different societal sectors, such as education, health, and policy. Inclusion laws and regulations in Chile are relatively new and have been taken as a regional model. However, the efforts to implement them have revealed some structural difficulties that must be discussed. This conceptual analysis article aims to provide insights to enrich cross-sectoral collaboration to foster inclusive cultures in Chilean schools. Considering the OECD Analytical Framework, which describes a systemic approach, we provide definitions for the critical components of the model and discuss the advances and challenges of current Chilean public policies in this field –including the Chile Crece Contigo and the School Integration Programs (SIP)—, the Chilean education system functioning, the social contexts, and students’ needs and supports based on the available evidence. Building from inclusive education literature and previous experiences, we delve into the model to address the needs of students with disabilities, social and cultural disadvantages, students belonging to the indigenous population, and students with a low socioeconomic level to propose action guidelines with a particular focus on integrating inclusive practices at the school level.
From real to virtual prism adaptation therapy: a systematic review on benefits and challenges of a new potential rehabilitation approach
Authors: Culicetto Laura , Giustiniani Andreina , Lo Buono Viviana , Cazzato Valentina , Falzone Alessandra , Vicario Carmelo Mario , Quartarone Angelo , Marino Silvia
Published: June 2024

Prism adaptation (PA) is a sensorimotor technique that has been shown to alleviate neglect symptoms. Due to its demonstrated functional effectiveness, PA has recently been implemented in virtual reality environments. However, research on virtual prism adaptation (VPA) is limited and it lacks a standardized methodological approach. It is crucial to investigate whether VPA can be effective in inducing traditional effect of PA and to have potential utility in a rehabilitation context. Clarifying this aspect would allow the use of VPA in a wider range of contexts and neurological disorders, with the additional opportunity to overcome PA traditional limits. The aim of the present study is to revise current literature on VPA in both healthy individuals and patients highlighting also its advantages and limitations. Studies performed between 2013 and 2023 and fulfilling the inclusion criteria were searched on three electronic databases, by combining the terms “Virtual prism adaptation” and “Virtual prism adaptation therapy. Out of 123 articles, only 16 met the inclusion criteria. The current literature review suggests that VPA may serve as a potentially useful tool for inducing visuomotor adaptation, with most studies conducted in healthy individuals. The high variability in the methodologies observed among studies suggests that more standardized approaches are needed to gain a deeper understanding of the mechanisms underlying adaptation and aftereffects when PA is administered in a virtual environment. Future studies should also address practical applications and clinical efficacy of VPA, particularly in patients with spatial neglect.
Light travel time effects in blazar flares
Authors: Finke Justin D.
Published: June 2024

In this study, a model for light travel time effects for emission from a plasma blob in a blazar jet is presented. This calculation could be incorporated into more complex models with particle acceleration and radiation mechanisms, but as presented here, it is agnostic to these mechanisms. This model includes light travel time effects for an expanding or contracting blob. As examples, this model is applied to a flare observed by VERITAS and MAGIC from Mrk 421 in 2013 and a flare observed by the Fermi Large Area Telescope from 3C 454.3 in 2010.
Gust Load Alleviation Control Strategies for Large Civil Aircraft through Wing Camber Technology
Authors: Zhang Shanshan , Qiu Yueheng , Sun Junshuai , Wang Ban , Gao Zhenghong
Published: June 2024

This paper introduces three new gust load alleviation control strategies, which are based on variable camber technology, to achieve the design requirements for the safety, economy, and comfort of modern civil aircraft. These strategies involve adjusting the inner and outer flap differential of wings, spoilers, and ailerons to alter the aerodynamic shape of the aircraft structure, resulting in drag reduction and gust load alleviation during stepped cruise flights. Furthermore, a logic design is provided for both the cruise drag reduction function and the gust load alleviation function. To validate the effectiveness of the proposed gust load alleviation control strategies, simulation results are presented, utilizing ride quality and wing root bending moment changes as the evaluation criteria. The presented approaches ultimately lead to the development of an optimal scheme that meets the desired design requirements.
Evaluating the Impact of Digital Health Interventions on Workplace Health Outcomes: A Systematic Review
Authors: Kechagias Evripidis P. , Papadopoulos Georgios A. , Rokai Ioanna
Published: June 2024

With the increasing penetration of digital technologies into health management, digital health interventions in workplaces have been subject to substantial interest. These interventions aim to enhance employee well-being, minimize absenteeism and presenteeism, and augment organizational productivity. This paper carries out a systematic review focusing on the key characteristics of effective digital health interventions designed to enhance health-related outcomes within workplace settings and evaluates their implications for prospective implementation in the workplace. According to PRISMA guidelines, the current systematic review adopted the most appropriate methods to retrieve studies from PubMed, covering interventions that included cognitive-behavioral therapy apps, software that reduces sedentary behaviors, virtual reality for well-being, and comprehensive health programs. The studies’ quality was assessed through standardized tools with a preference for randomized control trials and mixed-methods research. It was found that digital health interventions positively impact mental health, physical activity, and well-being. However, limitations were found due to self-reported data and potential biases. This review identified long-term effectiveness, objective outcome measures, and cost-effectiveness as areas for future research. Digital health interventions hold promise in enhancing workplace health strategies, as they offer scalable, personalized, cost-effective solutions. However, critically relevant research gaps have to be faced to integrate these successfully and exploit their real potential in organizational health strategies.
A Smart Wing Model: From Design to Testing in a Wind Tunnel with a Turbulence Generator
Authors: Ursu Ioan , Tecuceanu George , Enciu Daniela , Toader Adrian , Nastase Ilinca , Arghir Minodor , Calcea Manuela
Published: June 2024

The paper concerns the technology of the design, realization, and testing of a flexible smart wing in a wind tunnel equipped with a turbulence generator. The system of smart wing, described in detail, consists mainly of: a physical model of the wing with an aileron; an electric servomotor of broadband with a connecting rod-crank mechanism for converting the rectilinear motion of the servoactuator into the aileron deflection; two transducers: an encoder for measuring the deflection of the control aileron and an accelerometer mounted on the wing to measure its bending and torsional vibrations; a procedure for determining the mathematical model of the wing by experimental identification; a turbulence generator in the wind tunnel; implemented ℋ∞ and LQG algorithms for active control of vibrations. The attenuation experimentally obtained for the aeroelastic vibrations of the wing, but also for those accentuated by the turbulence, reaches values of up to 50%.
The U.S. Air Force Next-Generation Air-Refueling System: A Resurgence of the Blended Wing Body?
Authors: Fernandes Guilherme , Maldonado Victor
Published: June 2024

The interest in flying wings dates as far as the early years of the aviation age. Early investigations of the feasibility of the concept demonstrated increased aerodynamic efficiency and reduced fuel consumption. However, structural, engine integration, and stability and control issues prevented further development. In the 1990s, a new concept, the blended wing body (BWB), was created to alleviate some of the concerns of flying wings while maintaining increased efficiency and adding further benefits, such as reduced pollutant and noise emissions. Despite the promise, technical hurdles once again proved to be a deal breaker and, as of 2024, the only successful flying wing is the B-2 Spirit, an extremely complex and expensive aircraft. Nowadays, with the world quickly transitioning towards cleaner energy, the interest in the BWB has been renewed. The latest technological advancements in the aerospace industry should make its development more plausible; however, passenger comfort issues remain. Surprisingly, the BWB development may come from an unexpected application, as a tanker aircraft. As the U.S. Air Force is seeking a replacement to hundreds of aging tankers, a startup company was recently funded to develop the concept and build a prototype. In this study, we explore the history of blended designs from its early days, highlighting its opportunities and challenges—and why the design is an intriguing fit for application as a tanker aircraft.
Pixel-Wise and Class-Wise Semantic Cues for Few-Shot Segmentation in Astronaut Working Scenes
Authors: Sun Qingwei , Chao Jiangang , Lin Wanhong , Wang Dongyang , Chen Wei , Xu Zhenying , Xie Shaoli
Published: June 2024

Few-shot segmentation (FSS) is a cutting-edge technology that can meet requirements using a small workload. With the development of China Aerospace Engineering, FSS plays a fundamental role in astronaut working scene (AWS) intelligent parsing. Although mainstream FSS methods have made considerable breakthroughs in natural data, they are not suitable for AWSs. AWSs are characterized by a similar foreground (FG) and background (BG), indistinguishable categories, and the strong influence of light, all of which place higher demands on FSS methods. We design a pixel-wise and class-wise network (PCNet) to match support and query features using pixel-wise and class-wise semantic cues. Specifically, PCNet extracts pixel-wise semantic information at each layer of the backbone using novel cross-attention. Dense prototypes are further utilized to extract class-wise semantic cues as a supplement. In addition, the deep prototype is distilled in reverse to the shallow layer to improve its quality. Furthermore, we customize a dataset for AWSs and conduct abundant experiments. The results indicate that PCNet outperforms the published best method by 4.34% and 5.15% in accuracy under one-shot and five-shot settings, respectively. Moreover, PCNet compares favorably with the traditional semantic segmentation model under the 13-shot setting.
Impact of Feeding Systems on Performance, Blood Parameters, Carcass Traits, Meat Quality, and Gene Expressions of Lambs
Authors: dos Santos Isabela J. , Dias Junior Paulo C. G. , Alvarenga Tharcilla I. R. C. , Pereira Idalmo G. , Gallo Sarita B. , Alvarenga Flavio A. P. , Furusho-Garcia Iraides F.
Published: June 2024

The aim of this study was to investigate the effects of feeding systems on the growth performance of Santa Inês x Dorper lambs, meat quality, fatty acid profile, and gene expression. Thirty lambs at an initial body weight of 22.6 ± 2.59 kg were randomly assigned to one of three feed systems: a grazing system with 1.2% body weight concentrate supplementation (GS); a feedlot system with 28% forage and 72% concentrate (FFC); or feedlot with 85% whole corn grain and 15% pellets (FHG). The lambs were slaughtered after 60 days of experiment. Average daily gain, glucose, and insulin concentration were higher for lambs on FHC than lambs on a GS feeding system. The fatty acid profile in the meat of the lambs fed GS showed a higher proportion of c9t11-C18:2, C20:5, C22:5, and C22:6 compared with FFC and FHC (p < 0.05). Meat tenderness was lower for lambs under FFC treatment compared with GS and FHG. FHG treatment provides better performance and higher deposition of lipid content in meat compared with GS and FHG. The expression of the genes SCD-1, SREBP1-c, and EVOL6 was greater in lambs undergoing GS and FHC treatments compared with FFC. Results of this research showed a reduced performance of grazing lambs compared with the feedlot system; however, it enhanced the fatty acid profile with increased levels of polyunsaturated acids and reduced n6/n3 ratio.
Moving toward Automaticity: A Robust Synthetic Occlusion Image Method for High-Throughput Mushroom Cap Phenotype Extraction
Authors: Wei Quan , Wang Yinglong , Yang Shenglan , Guo Chaohui , Wu Lisi , Yin Hua
Published: June 2024

Mushroom cap is a key trait in the growth process and its phenotypic parameters are essential for automatic cultivation and smart breeding. However, the edible mushrooms are usually grown densely with mutual occlusion, which is difficult to obtain the phenotypic parameters non-destructively. Although deep learning methods achieve impressive performance with superior generalization capabilities, they require a large amount of ground truth label of the occluded target, which is a challenging task due to the substantial workload. To overcome this obstacle, a novel synthetic cap occlusion image method was proposed for rapidly generating edible mushroom occlusion datasets using raw images, in which the ground truth is obtained from the real world and the occlusion is randomly generated for simulating real scenes. Moreover, variants of amodal instance segmentation models with different backbone were trained and evaluated on our synthetic occlusion image datasets. Finally, an amodal mask-based size estimation method was presented to calculate the width and length of the cap. The experimental results showed that the amodal instance segmentation achieved an AP@[0.5:0.95] of 82%, 93% and 96% on Oudemansiella raphanipes, Agrocybe cylindraceas and Pholiota nameko synthetic cap datasets, respectively, with a size of 1024 × 1024 px, which indicates that our occlusion image synthesis method can effectively simulate the real cap occlusion situation. The size estimation method achieved an R2 of 0.95 and 0.98 between predictive amodal caps and manually labeled caps for the length and width of Agrocybe cylindraceas cap, respectively, which can be applied to obtain the phenotypic parameters of each cap effectively and accurately. These methods not only meet the demand for automatic monitoring of edible mushroom morphology in factories but also provide technical support for intelligent breeding.
Effect of Soil pH on the Uptake of Essential Elements by Tea Plant and Subsequent Impact on Growth and Leaf Quality
Authors: Jia Miao , Wang Yuhua , Zhang Qingxu , Lin Shaoxiong , Zhang Qi , Chen Yiling , Hong Lei , Jia Xiaoli , Ye Jianghua , Wang Haibin
Published: June 2024

Tea plant is an acidophilic plant, and soil pH has an important effect on the absorption and enrichment of elements, tea plant growth and quality. In this study, rhizosphere soils and leaves of tea plants from 30 tea plantations were collected to determine soil pH and multi-element content of soil and leaves of tea plants, to obtain and validate key elements that are enriched by pH affecting tea plants, and to analyze the effects of pH on the growth and quality of tea plants. The results showed that soil pH significantly affected the enrichment of 15 elements by tea plants, and the enrichment coefficients of 11 elements (C, Mg, Si, N, P, Mn, Sr, Cd, S, Ca and Sb) tended to increase significantly with the increase of soil pH, while the opposite was true for the other four elements (Cu, Rb, Ba and Al). TOPSIS analysis showed that soil pH had the greatest effect on tea plant enrichment of seven elements, namely N (100%), Mn (43.32%), C (39.22%), P (27.66%), Sr (15.30%), Mg (13.41%) and Ba (10.47%). Pot experiments with tea seedlings also verified that soil pH significantly affected the enrichment of tea leaves for seven key elements. Moreover, with the increase of soil pH, the growth indexes, photosynthesis indexes and quality indexes of tea seedlings showed a significant upward trend. Interaction analysis showed that the enhanced enrichment of N, Mn, C, P, Sr and Mg by tea plants was beneficial to increase the photosynthetic capacity of tea plants, promote the growth of tea plants and improve the quality of tea leaves. This study provides an important theoretical basis for the cultivation and management of tea plants.
The Association of Delayed Milk Ejection with Milking Performance in Holstein Cows in a Large Dairy Herd with Suboptimal Premilking Teat Stimulation
Authors: Singh Ajay , Spellman Madeleine Eve , Somula Haritha , Dahl Mohammad Osamah , Wieland Matthias
Published: June 2024

The primary objective was to investigate the association between delayed milk ejection (DME) and the average milk flow rate, milking unit-on time, and duration in a low milk flow rate in Holstein dairy cows in a large dairy herd with suboptimal premilking teat stimulation. Our second objective was to study the association between peak lactation milk yield and the occurrence of DME. This longitudinal field study was conducted at a 4300-cow dairy farm with a thrice-daily milking schedule over a 1-week period. We analyzed data from 61,677 cow milking observations from 2937 cows. Delayed milk ejection was defined as present if the 30–60 s milk flow rate was ≤3.1 kg/min. The mean average milk flow rate (MAMF, kg/min), mean milking unit-on time (MMUT, s), and mean duration of a low milk flow rate (MLMF, s) were calculated as the mean values from the 21 milking observations. General linear multivariable models revealed associations of DME with MAMF, MMUT, and MLMF. A multivariable ordinal logistic regression model revealed an association between peak lactation milk yield and DME. Cows with lower peak lactation milk yield had greater odds of exhibiting a higher frequency level of DME. The observed associations between DME and milking performance indices suggest that DME can negatively affect milking and parlor efficiency. Peak lactation milk yield may serve as a proxy to estimate cows’ risk of recurrent DME. Future research is warranted to test if alleviating DME through, for example, a modified milking routine influences the milking performance indices described herein.
Liver Histopathological and Immunohistochemical Evaluation from Fasciola hepatica Experimentally Infected and Reinfected Sheep
Authors: Herrera-Torres Guillem , Ruiz-Campillo María T. , Bautista María J. , Martínez-Moreno Francisco J. , Zafra Rafael , Buffoni Leandro , Rufino-Moya Pablo J. , Martínez-Moreno Álvaro , Molina-Hernández Verónica , Pérez José
Published: June 2024

Fasciolosis is an important economic disease of livestock. There is a global interest in the development of protective vaccines since the current anthelmintic therapy is no longer sustainable. A better knowledge of the host–parasite interaction is needed to design effective vaccines. To date, few studies have evaluated host–parasite interaction by comparing infected and reinfected animals. The present study evaluates the microscopical hepatic lesions in sheep infected and reinfected with Fasciola hepatica during the acute and chronic stages of infection. The histopathological study revealed the presence of necrotizing foci (NF1) associated with larvae migration during the early stages of infection in the primoinfected (PI) and reinfected (RI) groups. In the late stages of infection of the PI group and at the early and late stages of infection in the RI groups, extensive necrotizing/hemorrhagic foci (NF2) were found in the vicinity of enlarged bile ducts, some containing adult flukes, suggesting parasites may have caused NF2 while feeding. The immunohistochemical study revealed an increase in Foxp3+ T cells in both PI and RI groups with respect to the UC group and in the infiltrates adjacent to NF1 in the RI groups with respect to the PI group, suggesting the F. hepatica induce Foxp3 T cell expansion to facilitate parasite survival. In addition, in both the PI and RI groups, and during acute and chronic stages of the infection, a poor expression of iNOS was found accompanied by a strong expression of CD163, suggesting a marked M2 activation of macrophages in the hepatic lesions, which may be related with healing processes, and it also may facilitate parasite survival. The main differences between PI and RI animals were the more severe infiltration of eosinophils and Foxp3+ T cells, whereas RI did not modify M2 activation of macrophages which occurs since the early stages of primoinfection.
Locating Nesting Sites for Critically Endangered Galápagos Pink Land Iguanas (Conolophus marthae)
Authors: Gargano Marco , Colosimo Giuliano , Garizio Lorenzo , Gratton Paolo , Lewbart Gregory A. , Gerber Glenn P. , Loreti Pierpaolo , Catini Alexandro , Bracciale Lorenzo , De Luca Massimiliano , Mastrangeli Francesca , Sevilla Christian , Gentile Gabriele
Published: June 2024

Invasive alien species control is recognized worldwide as a priority action to preserve global biodiversity. However, a lack of general life history knowledge for threatened species can impede the effectiveness of conservation actions. Galápagos pink land iguanas (Conolophus marthae) are endemic to Wolf Volcano, Galápagos, Ecuador. These iguanas are threatened by invasive alien species, particularly feral cats, that may affect their small population size. To guarantee the long-term survival of C. marthae, the Galápagos National Park Directorate is considering, along with an ongoing campaign of feral cat control, the implementation of a head-start program. However, the success of this management strategy necessarily relies on the identification of pink iguana nesting grounds, which were still unknown at the onset of this study. We modeled the movement patterns of male and female iguanas during the reproductive season, using location data collected from custom-made remote tracking devices installed on adult pink iguanas in April 2021. We first calculated for each individual the vector of distances from its starting location, which was defined as net displacement. We then used net displacement as the response variable in a generalized additive mixed model with day of the year as the predictor. Based on the hypothesis that males and females may behaviorally differ after mating, we looked for female-specific migratory behavior suggesting females were moving toward nesting areas. The results obtained confirmed our hypothesis, as females exhibited a distinct migratory behavior, reaching a small plateau area inside of Wolf Volcano’s caldera and ca. 400 m below the volcano’s northern rim. Moreover, once inside the caldera, females displayed a more aggregated distribution pattern. The movement data obtained allowed Galápagos National Park rangers to locate individual pink iguana nests and subsequently to sight and collect the first observed hatchlings of the species. This work constitutes a necessary baseline to perform dedicated studies of pink iguana nests and emerging hatchling iguanas, which is an essential step toward the development of an effective head-start program.