bluuebunny/crossref_metadata_2025 huggingface dataset:
Accelerating Dental Adhesive Innovations Through Active Learning and Bayesian Optimization
Authors: Issa Ramsey , Sorenson Robert , Sparks Taylor D.
Published: May 2024

The discovery of new dental materials is typically a slow process due to high-dimensionality of the formulation space as well as the multiple competing objectives which must be optimized for a given application. Here, we lay out a strategy using active learning and Bayesian optimization that has led to the discovery of 3 new high-performing formulations for dental adhesives within 29 experiments. We utilize curated data from 91 experiments with 43 different components, to reduce the design space and incorporate domain knowledge into our search. The success of this machine learning approach can be adapted to a multitude of dental materials to allow for the fast and efficient discovery of optimal new formulations, leading to enhanced performance, reduced development times, and ultimately more cost-effective and innovative solutions in dental healthcare.
Annealing 1,2,4-Triazine to Iridium(III) Complexes Induces Luminogenic Behaviour in Bioorthogonal Reactions with Stain Alkynes.
Authors: Cooke Lydia , Gristwood Katie , Adamson Kate , Sims Mark , Deary Michael , Bruce Dawn , Antoniou Antony , Walden Hannah , Knight James , Antoine-Brunet Timothé , Joly Marie , Goyard David , Lanoë Pierre-Henri , Berthet Nathalie , Kozhevnikov Valery
Published: May 2024

Phenanthroline-type ligand containing annealed 1,2,4-triazine ring was used to prepare novel Ir(III) complexes 3 and 4. The complexes are non-luminescent but show luminogenic behaviour following inverse electron demand Diels-Alder (IEDDA) reaction with bicyclononyne (BCN) derivatives. It was observed that the complex 3 reacts with BCN-C10 three times faster than the corresponding free ligand 7. The magnitude of this accelerating metal-coordination effect, however, is less profound that in previously reported Ir(III) complexes of 1,2,4-triazines in which the triazine was directly coordinated to Ir(III) metal centre. Nevertheless, luminogenic behaviour opens prospects for the use of such complexes in bioimaging applications, which was demonstrated by developing a convenient methodology using “chemistry on the complex” concept for labelling antibodies with luminescent Ir(III) complexes. Bioorthogonal reactivity of the complex 4 was then evaluated by metabolically labelling live cells with BCN groups followed by luminogenic IEDDA reaction with the triazine iridium complex.
Glycolic acid and D-lactate—putative products of DJ-1—restore neurodegeneration in FUS - and SOD1-ALS
Authors: Pal Arun , Grossmann Dajana , Glaß Hannes , Zimyanin Vitaly , Günther René , Catinozzi Marica , Boeckers Tobias M , Sterneckert Jared , Storkebaum Erik , Petri Susanne , Wegner Florian , Grill Stephan W , Pan-Montojo Francisco , Hermann Andreas
Published: May 2024

Amyotrophic lateral sclerosis (ALS) leads to death within 2–5 yr. Currently, available drugs only slightly prolong survival. We present novel insights into the pathophysiology ofSuperoxide Dismutase 1(SOD1)- and in particularFused In Sarcoma(FUS)-ALS by revealing a supposedly central role of glycolic acid (GA) and D-lactic acid (DL)—both putative products of the Parkinson’s disease associated glyoxylase DJ-1. Combined, not single, treatment with GA/DL restored axonal organelle phenotypes of mitochondria and lysosomes in FUS- and SOD1-ALS patient-derived motoneurons (MNs). This was not only accompanied by restoration of mitochondrial membrane potential but even dependent on it. Despite presenting an axonal transport deficiency as well, TDP43 patient-derived MNs did not share mitochondrial depolarization and did not respond to GA/DL treatment. GA and DL also restored cytoplasmic mislocalization of FUS and FUS recruitment to DNA damage sites, recently reported being upstream of the mitochondrial phenotypes in FUS-ALS. Whereas these data point towards the necessity of individualized (gene-) specific therapy stratification, it also suggests common therapeutic targets across different neurodegenerative diseases characterized by mitochondrial depolarization.
Precarização da assistência social e marco regulatório das organizações sociais
Authors: PEREIRA ILZAMAR SILVA
Published: May 2024

Este estudo versa sobre a Precarização da Assistência So- cial e a privatização do fundo público: o Marco Regulatório das Or- ganizações da Sociedade Civil (MROSC) referendado pelo Projeto Neoliberal, oculta “interesses públicos” conservadores que resultam, por um lado, na precarização da Assistência Social e na privatização do fundo público e, por outro, no fortalecimento do “Terceiro Setor”, transformando-o em um novo fetiche de enfrentamento das desigual- dades sociais na realidade brasileira. Porém, nessa perspectiva, apesar de o MROSC expressar uma concepção de convivência “harmônica” nessa relação de “parceria” entreEstado e sociedade civil, fortalecen- do o “terceiro setor”, essa dinâmica se efetiva com respaldo do próprio Estado, no sentido de escamotear os conflitos sociais inerentes à sociabilidade do capital, porque tanto o SUAS (primeiro setor) quanto as ONGs (terceiro setor) estão a serviço da hegemonia do capital, sen- do o fundo público um processo sempre em disputa.
Theoretical Aspects of Shaping a Regional Resilient System of Industrial and Personnel Recovery in the Post-War Period
Authors: Gibadullin Oleksii , Kosenko Viktor
Published: May 2024

The article focuses on the importance of a methodological approach to building a system for sustainable industrial recovery and attracting qualified labor to the regional economy even during wartime. The purpose of the article is to scientifically substantiate the conceptual apparatus and methodological-theoretical basis for the restoration of industrial potential in Ukrainian regions during the period of martial law. The author notes that a key element in the process of forming a system of sustainable industrial recovery is understanding the scale of damages and the availability of qualified labor for recovery based on sectoral priorities. This requires a broad scientific perspective on this extraordinary problem and, consequently, a comprehensive approach. Such an approach would combine both the analysis of the current state of industrial facilities and the determination of the need for personnel and resources for modernization, taking into account both local resources and external factors, including the availability of financing, technological innovations, and international support. Currently, there are still certain terminological and scientific «gaps» in the principles of organization of recovery and the conceptual apparatus related to the restoration processes in the industrial sector of Ukraine today. The article reveals the terminology for revising the system of sustainable industrial recovery during the period of martial law and post-victory as a prerequisite for post-war recovery and sustainable development of the regions, which is a basic condition for searching and implementing ways to optimally use available resources, overcome technological gaps, and create conditions for the return of skilled migrants to Ukraine
Compliance with the Requirements of Ukrainian Legislation on the Provision of Administrative Services in Administrative Centers of Eastern Ukraine
Authors: Konotoptsev Oleg
Published: May 2024

This paper presents the results of an independent assessment of administrative service centers in Eastern Ukraine. The evaluation was conducted in the summer of 2023 using the open-source research method (OSINT) - official websites of city councils or their administrative service centers. The study was carried out based on ten criteria stipulated by Ukrainian legislation on the provision of administrative services. Sixteen territorial communities, which are district centers of Eastern Ukraine and were not occupied by the enemy at the time of the study, were evaluated. The assessment revealed that none of the communities fully complied with all the legal requirements for the provision of administrative services. It was found that the requirement regarding the publication of contact information and details about the access regime to the premises was most fully met. However, the most frequently violated requirement was regarding the reception of visitors until 20:00 and the publication of information about the availability of public transport connections
Specifics of Interaction Between Authorities And Community in the Conditions of Digitalization of a Public Administration System
Authors: Solovykh Vitaliy
Published: May 2024

The article was prepared within the framework of the implementation of the grant project No. 2022.01/0144 „Implementation of the concept of „Public participation 2.0” for the reconstruction of the city of Kharkiv in the war and post-war periods”, financed by the National Research Fund of Ukraine. Digitization of society has a significant impact on all spheres of life, including the public administration system. The introduction of digital tools and platforms transforms the ways in which the government and the community interact, making them more open, transparent, interactive and accountable. This article explores the specific features of the interaction between the government and the community in the context of the digitalization of the public administration system. The article develops a typology of models of interaction between the government and the community in the digital environment. It identifies and substantiates the advantages and challenges associated with the digitalization of government-to-community interaction. The article also develops practical recommendations for improving government-to-community interaction in the context of digitalization. The research results can be used to improve the public administration system, increase the level of citizen participation in decision-making, increase transparency and accountability of the government, and develop e-democracy.
Strategies for Improving Diet Education for Children Under the Background of Building a Healthy China
Authors: Wang Yinbiao , Mei Jie , Ding Genxiao , Li Peng
Published: May 2024

Diet education can expand children’s life experience, cultivate good living habits, and develop their character, contributing to the construction of a healthy China. Developing diet education helps children improve their health awareness and enables them to form healthy eating behaviors and lifestyles, laying the foundation for their healthy growth and lifelong development. It is not just about disseminating nutrition knowledge but also involves the integration of health education, labor education, and family education through practical experiences. This study analyzes the importance of promoting diet education for children and proposes four promotion strategies that draw on families, schools, relevant departments, and social groups, as well as pilot projects. The application of these strategies will help enhance the effectiveness of diet education and enable children to form healthy eating habits and develop the basic ability to maintain their health.
Analysis of Young Learners’ Listening Skills
Authors: Tang Wanqi , Wan Qing
Published: May 2024

The importance of listening as one of the communication skills cannot be overstated. However, in many areas, listening is neglected. For young learners, learning to listen is even more beneficial for their future studies, therefore, listening skills should be given due importance.
The Development and Innovation of Vocational Education from the Perspective of Lifelong Education
Authors: Cui Weina
Published: May 2024

With the continuous advancement of technological innovation, lifelong education has become a key factor in personal career development and social progress. As an important part of the lifelong education system, the development and innovation of vocational education are of great significance to meet the needs of the labor market and promote social equity and economic growth. This article analyzes the intrinsic relationship between the concept of lifelong education and vocational education, focusing on analyzing the development and innovation strategies of vocational education from the perspective of lifelong education.
Teaching Research and Effect Observation on the Integration of Clinical Medicine Integrated Course and Ideological and Political Elements from the Perspective of “Sanquan Education”
Authors: Liu Wensi , Zhao Chunyan , Kong Xiangying , Ji Zhiwu , Yu Cuicui , Song Fuxiang , Shang Jincai
Published: May 2024

Purpose: To analyze the application path of the integration of clinical medicine integrated courses with the elements of ideology and politics under the theory of “Sanquan Education,” and to provide references for the promotion of educational reform in medical schools. Methods: 60 clinical medicine undergraduates at Jiamusi University in 2018 and 2019 were randomly selected as research subjects. On the basis of the analysis of students’ characteristics and pre-study content, the students were divided into the integration group and the traditional group, each with 30 students. Students in the integration group carried out clinical medicine integrated class with the integration of ideological and political elements. Students in the traditional group carried out the traditional clinical medicine integrated class. Classroom evaluation scales, anonymous questionnaires, and interviews were used to conduct research, collect data, and compare and observe the application effects. Results: After carrying out different modes of clinical medicine integrated courses, the undergraduates of the Excellent Physician Class in the integration group were higher than those in the traditional group in terms of teaching satisfaction, comprehensive quality, basic knowledge test, and case analysis scores through questionnaire analysis (P < 0.05). In the evaluation of the effect of ideological education, the undergraduates of the Excellent Physician Class of the integration group were higher than the traditional group in terms of the acceptance of doctor-patient communication, the correct rate of mastering the history of the discipline, and the correct rate of mastering the frontiers and policies (P < 0.05). Conclusion: Through the integration of clinical medicine integrated course and ideological and political elements, we can help students establish correct values while teaching them professional knowledge, improve the implementation of moral education in medical schools, cultivate excellent medical workers with high morality and firm beliefs for the society, and realize the fundamental educational task of establishing morality and educating people in medical schools in the context of “Sanquan Education.”
Division of Powers of Public Authorities in Modern Conditions
Authors: Zambaev Kh. N.
Published: May 2024

In the context of the implementation of the provisions of the Constitution of the Russian Federation regarding the formation of a unified system of public power, the issue of improving the delimitation of powers of public authorities remains relevant. Significant amount of problems has been accumulated over the course of more than twenty-five years. This fact has an impact on the sustainability of regional budgets. The author of the article is considering the authority of regional government bodies in questions of joint jurisdiction of the Russian Federation and its constituent entities. The purpose of the work is to develop recommendations for improving the division of powers of public authorities and financial support this process from the position of increasing the sustainability budgets of the constituent entities of the Russian Federation. In the course of the work, based on scientific methods such as institutional, retrospective and comparative analyses, it was concluded that there are problems in the mechanism for delimiting regional powers that impede the increase in the sustainability of regional budgets. The main results of the study include suggestions for the harmonization of budget legislation and legislation in the field of delimitation of powers from the position of expanding the rights of regions to participate in the implementation of non-transferred powers, regulation of the process of introducing new powers, inventory count of regional powers established by subordinate legislation or bylaws, introduction of the practice of financial support for certain regional powers in cases and to the extent of receipt of certain non-tax revenues and the development of debt financing instruments for powers, as well as for improving the practice of financial support for delegated powers. The prepared recommendations may be useful when conducting the inventory count of regional powers from the standpoint of increasing the sustainability of regional budgets; introducing a reasonable assessment of the resource provision for new powers proposed for the implementation; shifting the emphasis from the subordinate or by-law regulation of regional powers towards strengthening their legislative regulation.
Definition and Key Attributes of Impact Investments as an Object of Management
Authors: Aksakova N. V.
Published: May 2024

Since the introduction of the term “impact investments” into active use in 2007, the debate about their content and distinctive characteristics in comparison with other classes of investments remain open. To date, there are many different, and in some cases incompatible, points of view in interpreting their definition. This complicates the effective management of impact investments and hinders the pace of industry scaling. The purpose of the paper is to analyze and systematize theoretical and practical approaches to defining the concept of impact investments, as well as to identify their inherent demarcation features that determine the management features and peculiarities. The research methodology includes the analysis of publications in peer-reviewed scientific journals, comparison of the content of reports and reports of international organizations and institutions, as well as quantitative and qualitative content analysis of media materials relevant to this topic. The results obtained indicate the validity of accepting impact investments as an independent conceptual category and the expediency of their allocation and separation into an independent class of investments; their key attributes are established; the principles and features of the management approach applied to them are revealed. The paper has practical significance for actors and participants of the investment sphere as well as researchers and practitioners interested in innovative approaches to investing in social and environmental well-being.
Establishing a Material Description Table to Optimize Mandarin Proficiency for Indonesian Learners: An Applied Contrastive Analysis Perspective
Authors: Adhimas Yogi Bagus , Ahmadi Anas , Amri Miftachul , Raharjo Resdianto Permata , Tjaturrini Dyah , Deng Boer
Published: May 2024

Abstract. This study aims to elucidate the most contrasting differences between Mandarin and Indonesian language rules. Based on the analysis results, it is hoped that this can serve as a foundation for creating a learning media, namely a descriptive material table. The study reveals that the most contrasting rule lies in the Indonesian language auxiliary number words, which have no more than 30 auxiliary number words, whereas in Mandarin, or known as 量, there are over 200 such words. Additionally, there is a rule for constructing past tense sentences. In Indonesian, a word meaning “finished” is used to indicate the past, contrasting with Mandarin, which employs the particle “了”, which can also have different meanings according to different rules. Furthermore, there is a Numeral system rule where Indonesian simply translates numbers into letters, while Mandarin has specific and detailed rules; this clearly presents a contrasting difference. There is also a rule on reduplication, or in Mandarin termed 重叠, where the quantity of rules between the two languages is almost balanced, yet the functions of usage are vastly contrasting. Lastly, there is the rule of “离合词”, a Mandarin language rule that has no equivalent in Indonesian. The method employed is a mixed-method approach, along with a narrative elaboration model based on quantitative differences in the amount of data between Mandarin and Indonesian languages, which are then expounded upon qualitatively. The data source used is the Confucius Institute (孔子学院) recommended books: 标准教程 Standard Course HSK (Hanyu Shuping Kaoshi / Chinese Proficiency Tes) 1 - 6 下 (Part 2). Data analysis techniques include identification, classification, and presentation of the results of data analysis. The results of the research and presentation show that there is a big gap between Mandarin and Bahasa Indonesia linguistic tools, with each of the rules that bind it. Therefore, it is necessary to develop a learning media to reduce this gap.Keywords: Material description table, Applied Contrastive Analysis, Mandarin, Indonesian Learners.
An outbreak of Legionnaires’ disease linked to a municipal and industrial wastewater treatment plant, The Netherlands, September–October 2022
Authors: Pijnacker Roan , Brandsema Petra , Euser Sjoerd , Vahidnia Ali , Kuiter Arnold , Limaheluw Jesse , Schout Christine , Haj Mohammad Gaaled , Raven Stijn
Published: May 2024

Wastewater treatment plants (WWTPs) are increasingly identified as Legionnaires’ disease (LD) sources. An outbreak investigation was initiated following five LD cases reported in September 2022 in Houten, the Netherlands. Case identification was based on the European LD case definition, with symptom onset from 1 September 2022, residence in or within 5 km of Houten, or visit to Houten within the incubation period, without other likely sources. We sampled potential sources and genotyped environmental and clinical isolates. We identified 15 LD cases with onset between 13 September and 23 October 2022. A spatial source identification and wind direction model suggested an industrial (iWWTP) and a municipal WWTP (mWWTP) as potential sources, with the first discharging water into the latter. Both tested positive for Legionella pneumophila serogroups 1 and 6 with multiple sequence types (ST). We detected L. pneumophila sg1 ST42 in the mWWTP, matching with one of three available clinical isolates. Following control measures at the WWTPs, no further cases were observed. This outbreak underlines that municipal and industrial WWTPs can play an important role in community LD cases and outbreaks, especially those with favourable conditions for Legionella growth and dissemination, or even non-favourable conditions for growth but with the influx of contaminated water.
Intervención fonoaudiológica mediante la estimulación de las neuronas espejo en niños con trastorno del espectro autista
Authors: Naranjo Restrepo Angie Lorena , Ramírez Rosero Jenniffer Alexandra , Pedraza Vargas Steve Fernando
Published: May 2024

Introducción. Los nuevos aportes sobre el trastorno del espectro autista (TEA) y la estimulación de las neuronas espejo tienen aplicabilidad en los procesos de intervención fonoaudiológica ya que la teoría de las neuronas espejo, descrita en 2009 por Iacoboni, establece que las personas con esta condición presentan un déficit en la imitación, además de un desarrollo casi nulo de la empatía, lo cual causa alteraciones en las conductas y los comportamientos sociales.Objetivo. Construir, a partir de la teoría de las neuronas espejo, un protocolo de intervención para habilidades de interacción social en población infantil (4-6 años) con TEA con nivel de apoyo 1 con el fin de propiciar una intervención fonoaudiológica con un enfoque ecológicamente válido.
Métodos. El estudio se desarrolló acorde al método de investigación mixta con predominancia cualitativa, siendo este de tipo transversal y alcance descriptivo con diseño mixto anidado multinivel en seis etapas.
Resultados. Los módulos conceptuales del protocolo de intervención para habilidades de interacción social diseñado comprenden la atención conjunta, la imitación verbal y no verbal, la intencionalidad comunicativa, la comprensión y expresión de emociones y las habilidades de juego. Se enfatiza que este protocolo se basa en la atención conjunta, pues esta es la primera condición sobre la cual se construye la comunicación y, por ende, se desarrollan las habilidades de interacción social.
Conclusiones. Un protocolo de intervención desarrollado bajo un modelo ecológico permite la adaptación de las actividades de intervención a los entornos naturales a partir de estímulos representativos, logrando así eficiencia en el desarrollo de habilidades de interacción guiada a los diferentes contextos sociales típicos.
Frequency of asymptomatic bacteriuria, causative pathogens and antibiotic sensitivity pattern in antenatal women.
Authors: Summaira Perveen  , Sadia Khadim  , Humaira Bashir  , Hina Iqbal  , Anza Shahzadi  , Syeda Ayesha Qamar
Published: May 2024

Objective: To determine the frequency of asymptomatic bacteriuria (ASB), causative pathogens and antibiotic sensitivity pattern in antenatal women. Study Design: Cross-sectional study. Setting: Department of Obstetrics and Gynaecology, Nishtar Hospital, Multan, Pakistan. Period: February 2022 to July 2023. Methods: A total of 110 women with singleton pregnancy with gestational age 13-42 weeks, and aged 18 to 40 years were included. Once the patients were enrolled, demographic characteristics (age, gestational age, parity (primiparous or multiparous), body mass index (BMI), place of living (rural or urban), gestational diabetes mellitus (yes or no), educational status (illiterate, primary, middle, matric, or graduate)) were noted. Presence or absence of asymptomatic bacteriuria was noted. Results: In a total of 110 pregnant females, the mean age and gestational age were 28.7±3.9 years and 29.4±4.0 weeks, respectively. The frequency of ASB among pregnant women was found in 19 (17.3%) patients. The frequency of causative pathogens showed that E. coli was the most frequent isolates noted among 7 (36.8%) women while staphylococcus aureus, Klebsiella, pseudomonas spp, and Proteus spp were identified in 5 (26.3%), 4 (21.0%), 2 (10.5%), and 1 (5.26%) respectively. Antibiotic susceptibility patterns revealed that Amikacin, Nitrofurantoin, cephalexin, and Ciprofloxacin were the most sensitive antibiotics noted in 18 (94.7%), 17 (89.5%), 15 (79.0%) and 14 (73.7%) samples respectively. Conclusion: The frequency of asymptomatic bacteriuria in pregnant women is high with E. coli as the most common causative organism. Antibiotic susceptibility patterns revealed that Amikacin, Nitrofurantoin, cephalexin, and Ciprofloxacin to have good sensitivities.
Basquetebol Feminino e Educação
Authors: Rojas Vanessa Melina Cotrim , Vagetti Gislaine Cristina , Oliveira Valdomiro de
Published: May 2024

O livro – Basquetebol Feminino e Educação: suportes escolar e parental, desempenho acadêmico e vivência esportiva no contraturno escolar, foi elabora com o maior rigor científico da atualidade para você leitor, abordando as teorias da Educação e do Esporte com as teorias que fundamentam o basquetebol, o envolvimento escolar na formação esportiva, o envolvimento familiar na formação esportiva e o desempenho acadêmico. O esporte é um fenômeno cultural que proporciona benefícios em diversos segmentos da vida, tais como os aspectos sociais, da saúde, biológicos e psicológicos. Fomos a campo e investigamos a relação dos suportes escolar e parental com o desempenho acadêmico por meio da vivência esportiva de alunas/atletas de Basquetebol da Região Metropolitana de Curitiba. Os resultados, estatisticamente, mostram a importância da família da escola e das relações com o treinador na conduta pedagógica do trabalho com meninas jovens praticantes de basquete no contraturno escolar e seu desempenho acadêmico.
Being Foreigner in Their Own Land: The Samin Movement in Madiun East Java in Early Twentieth-Century
Authors: Wahyudhi Johan
Published: May 2024

This article explains that the movement of the Samin community at the end of the 19th century in Java caused a stir in colonial society. Typical of village communities in general, they spent their days in agrarian activities. However, there was a problem, which caused them to migrate to several areas in East Java, including Madiun, and then they were known to have carried out a number of acts of resistance against the local colonial government. This research will use historical research methods, armed with reading a number of documents and archives left by the Dutch East Indies Government. The concept of social movement becomes the locus that is put forward to explore the various activities of the Orang Samin in their new areas. The purpose of writing this article is to show that the end of the 19th century became a period of crisis for Madiun, where various elements of popular resistance emerged to oppose the arrogance of the Dutch East Indies government.
Analisis Peninggalan Keagamaan Hindu-Buddha di Kedatuan Sriwijaya: Perspektif Sosio-Kultural
Authors: Susanti LR Retno , Fathiah Hunsnul , Mariyani Mariyani , Hidayanti Mailiza , Oktarina Tia
Published: May 2024

This research aims to discover how the existence and development of the Hindu-Buddhist religion in Kedatuan Sriwijaya influenced society's social structure, culture and values at that time. The methods used in this research are literature study, field data collection, archaeological analysis, and interviews with historical and cultural experts. Religious life in the Srivijaya Kingdom, founded around the 7th to 14th centuries AD, was dominated by Hinduism and Buddhism. In that period, these two religions played an important role in shaping the culture, society, and politics of Sriwijaya. Socio-cultural, the start of the Cultural Integration of Hindu-Buddhist Heritage, reflects the solid cultural integration between these religions and local culture in Kedatuan Sriwijaya. Religious Harmony: this relic shows the existence of harmony between followers of these religions in Sriwijaya society. Religious Expansion: in this section, the Srivijaya chiefdom was essential in spreading Buddhism in Southeast Asia. Education Center Monks and Brahmins who visited Sriwijaya brought religious and cultural knowledge and influenced religious education. Economy and Trade started with Sriwijaya's strategy of developing the trade sector by building a substantial fleet of ships and controlling robust trading ports. Then, the artistic heritage, Hindu-Buddhist artistic and architectural heritage in Sriwijaya reflects the influence of the culture and religious beliefs that inspired it.
Strategi Pengembangan Kawasan Wisata Sejarah Monumen Kresek Terintegrasi Agrowisata Berbasis Community-Based Tourism (CBT) di Kabupaten Madiun
Authors: Soebijantoro Soebijantoro , Hartono Yudi , Huda Khoirul
Published: May 2024

This research aims to reveal the development of the Kresek Monument historical tourism area for agrotourism based on Community Based Tourism. Qualitative descriptive research method. Data collection through observation, interviews, focus group discussions, and document study. Data validity through source triangulation. Analyze data with interactive analysis. The results of the research show that the Kresek Monument historical tourist area needs to be developed with a new perspective that the landscape of the Kresek Monument historical tourist area has the potential to become a beautiful natural tourist destination. For a long time, the community has been actively involved in developing the Kresek Monument historical tourist area through the "Mekar" Tourism Awareness Group. The community took the initiative and tried to integrate it with agrotourism around the monument area. Since the COVID-19 pandemic, the management of the Kresek Monument historical tourist area has been completely taken over by the Madiun Regency Tourism, Youth and Sports Department, while day-to-day management is carried out by the Madiun Regency Environmental Service. The Kresek Village Government is also involved in management through the Kresek Village Village-Owned Enterprise. Residents are involved based on assignments from these parties, such as tour guides. There is no policy synergy between stakeholders, which is a challenge in developing the Kresek Monument historical tourism area which is integrated with the community's agro-tourism area. The community is also faced with technical obstacles in the field in the form of road infrastructure connecting the Kresek Monument historical tourist area with unsupported agro-tourism areas.
Implementasi Pembelajaran Diferensiasi pada Mata Pelajaran Sejarah: Studi Kasus di SMAN 23 Kabupaten Tangerang
Authors: Jumiarti Dede Novita , Fakhruddin M. , Marta Nur Aeni
Published: May 2024

This article describes the implementation of differentiated learning in history subjects at SMAN 23 Tangerang Regency. This research method uses qualitative methods, with a single case study strategy. The research method in this study is a qualitative method. The validity of the data used in this research uses triangulation of data sources and methods. The data was obtained through in-depth interviews, observation and document study. Research results: First, the history teacher's learning planning has prepared and implemented a history module that uses a differentiated learning approach. Second, implementation of learning, history teachers apply learning in the form of differentiation of content, processes and products for material on ancestral origins, four theories of ancestral origins, and their relationship to current Indonesian society. Third, learning evaluation, teachers use assessments based on cognitive, affective and psychomotor aspects. Fourth, the impact of differentiated learning in history subjects is improving critical and creative thinking skills in history learning. Fifth, the obstacles experienced are inadequate facilities and infrastructure, and also insufficient learning time.
Revitalisasi Bangunan Cagar Budaya Gedung Juang Tambun sebagai Museum Digital Kabupaten Bekasi, 2019-2021
Authors: Imbron Imbron , Falah Miftahul , Kartika Nyai
Published: May 2024

This research was written to provide information and education about changes in the function of the Juang Tambun Building as a Digital Museum and the use of abandoned or neglected cultural heritage buildings. This research uses the Historical Method. In this method there are four heuristic stages, internal criticism and external criticism, interpretation, and historiography. The results of this research, the revitalization of the Juang Tambun Building as the Bekasi Regency Digital Museum, has had a positive impact on the surrounding community. The Juang Tambun Building is officially managed directly by the Bekasi Regency Culture, Youth, and Sports Department. In 2019, the Juang Tambun Building before being revitalized was only a cultural heritage building with no attractions to visit. In 2021, the Juang Tambun Building will officially become a digital museum that provides information about the history of the Bekasi Regency. The revitalization of the Juang Tambun Building has an influence on the economic aspects, educational aspects, and tourism aspects of the people of Bekasi Regency.
Resilience in supply chain management: lessons learned from disruptions like the COVID-19 pandemic
Authors: Omotolani Eniola Akinbolajo
Published: May 2024

The ravaging impacts of the COVID-19 pandemic on global supply chains and its exposures of the vulnerabilities of the supply chain process has been examined in this paper. Importantly, the failure of supply chain resilience and the post-COVID-19 lessons necessitated the need to examine the need for resilience in supply chain management process. The paper examined the concept of resilience and its application in supply chain management, and covered strategies for developing resilience in supply chain management, which includes: identification and assessment of associated risks, diversification of supply chain channels, enhancing collaborations and effective communication among stakeholders, inventory management and supply chain flexibility, technology adoption and digitalization, scenario planning and simulations, as well as robust continuity planning. The paper also identified the challenges of supply chain resilience building. The paper provides valuable insights into how organizations can better handle future supply chain operations by considering the intrinsic development of resilience, which will enable them to better withstand and quickly recover from future disruptions.
Formulation and evaluation of antifungal herbal gel using Aloe Vera and Betel leaves extract for the treatment of candidiasis
Authors: Saurabh D. Bahekar  , Rajesh Z. Mujariya  , Manjeet Singh
Published: May 2024

The primary objective of the current study was to develop and evaluate an antifungal herbal gel for the treatment of candidiasis using an extract from aloe vera and betel leaves. Herbal remedies are now widely used for both medicinal and commercial reasons. The antibacterial gel made from herbal plants works better than synthetic medications and has fewer side effects. Aloe vera belongs to the Asphodelaceae family, which also includes Aloe barbadensis. One species in the Piper betle L. family of Piperaceae is the betel leaf. Aloe vera and betel leaf products, such as plant branches, roots, and leaves, have also been shown to be abundant in phytochemicals. The most popular herbs for treating fungus infections are aloe vera and betel leaves, which also contain potent anti-inflammatory, antibacterial, and antifungal properties. Methods: Hydroalcoholic extract was prepared by the maceration method. Carbopol 940 was used as a gelling agent to create the gel formulation. Candida albicans has been used to test its antifungal properties. Evaluation:The pH, viscosity, homogeneity, grittiness, extrudability, spreadability, antifungal activity and in vitro drug release research were assessed for the optimally designed herbal gel. Results:In comparison to marketed 1% clotrimazole gel 25 mm and marketed herbal gel 20 mm, the aloe vera and betelleaf extract herbal gel (S4 Batch) was found to be brown in color, homogenous, had good extrudability, no grittiness, pH 6.8, viscosity of 3424±0.45, spreadability of 4.3±0.3, and zone of inhibition of 23 mm. After being stored for 60 days, the herbal gel mixture, including extracts of aloe vera, tulsi, and peppermint leaves, did not alter in appearance. The pH has not changed in two months.
Penguatan Nilai-Nilai Moderasi Beragama: Implementasi Pembelajaran pada Sekolah Berkebutuhan Khusus di Ponorogo
Authors: Sari Ulfi Andrian , Nuruddien Muhammad , Arumawan Muhammad Muhsin
Published: May 2024

Anak-anak berkebutuhan khusus masih ada yang diperlakukan diskriminatif di lingkungan masyarakat sehingga diperlukan pembelajaran berbasis moderasi beragama yang mengajarkan anti kekerasan,toleransi, patriotisme dan mencintai kearifan lokal daerahnya. Pembelajaran moderasi beragama untuk anak berkebutuhan khusus  memiliki tantangan tersendiri karena mereka memiliki tingkat pemahaman dan komunikasi yang terbatas. Tujuan dari pengabdian ini untuk penguatan nilai-nilai moderasi beragama dan implementasinya dalam pembelajaran di sekolah berkebutuhan khusus, Metode pengabdian menggunakan Partici­pa­tory Action Research dengan langkah membuat rencana peng­abdian dengan analisis kebutuhan melalui observasi dan wawancara, pe­lak­sanaan kegiatan dengan workshop kepada guru-guru sekolah luar biasa dan evaluasi kegiatan dilakukan dengan memberikan google form kepada peserta. Hasil pengabdian 1) Sekolah membutuhkan integrasi pembelajaran dengan penguatan moderasi beragama. 2) Implementasi moderasi ber­agama dalam pembelajaran a) implementasi toleransi dengan edukasi dan keteladanan, b) implementasi anti kekerasan dengan edukasi pelaku kekerasan dan orangtua, memberi motivasi dan perlindungan pada korban, c) implementasi kearifan lokal dengan mengenalkan dan mempraktikkan budaya lokal dan d} implementasi patriotisme dengan mengenalkan simbol Negara Kesatuan Republik Indonesia dan praktik nasionalisme. 3) Evaluasi pengabdian menunjukkan semua guru sangat puas mengikuti pelatihan. Hasil tingkat pemahaman guru terkait nilai moderasi  rata-rata pretest sebesar 69 % sedangkan nilai post test 90 % dengan peningkatan pemahaman peserta terhadap nilai-nilai moderasi beragama sebeser 21 %.
The Partitive Pronoun ER in Two National Varieties of Standard Dutch
Authors: Sleeman Petra
Published: May 2024

The Dutch partitive pronoun ER in general occurs in combination with an elliptical noun phrase in object position. According to the Dutch Reference Grammar, partitive ER in general occurs with a quantifier in this case. The Dutch Reference Grammar observes that there is natiolectal variation with respect to the use of partitive ER, focusing on the national varieties of Dutch used in the Netherlands and in Belgium.
In this paper, the acceptance of the use or omission of ER in different types of NPs by native speakers of the Netherlandic and the Belgian variety of Dutch is compared. It is shown that differences between the varieties go beyond those described by the Dutch Reference Grammar.
Влияние перемены климата на ботанический состав пастбищ и мясную продуктивность молодняка казахской белоголовой породы КРС в условиях степного Заволжья
Authors: Козлова Н. Н. , Анисимова Екатерина Ивановна
Published: May 2024

Глобальные климатические изменения прямо влияют как на естественные, так и искусственные пастбища, от которых зависит развитие сельскохозяйственных животных, особенно мясных пород. Увеличение урожайности пастбищ повышает продуктивность скота, который на 85 – 90 % находится в прямой зависимости от нее. От ботанического состава травостоя зависит качество травяного корма, его биологическая полноценность, урожайность трав, долголетие их использования. В период 2010 – 2020 гг. в Саратовской области проанализирован ботанический состав естественных пастбищ и исследовано их влияние на мясную продуктивность молодняка казахской белоголовой породы КРС в связи с перменой климата. В 2019 г. проведены работы по коренному улучшению пастбищ, что позволило повысить их продуктивность в 2,3 раза. В 2020 г. за счет улучшения пастбищ, несмотря на засушливый год, дополнительно повысилась питательность пастбищного корма — обеспеченность обменной энергией составила 107 – 105 % в весенне-летний период и 99,1 – 88,5 % в осенне-зимний. Обеспеченность переваримым протеином на протяжении пастбищного периода 2020 г. находилась на высоком уровне — 99,3 – 160,8 %, что позволило дополнительно получить к 18-месячному возрасту молодняка 16,3 кг живой массы.
Strategi Meneladani Sifat Shiddiq Rasulullah Saw pada Pendidikan Anak Usia Dini
Authors: Sari Tina Alfina , Lubis Zulfahmi
Published: May 2024

Pembentukan karakter pada anak dapat dilakukan dengan adanya keteladan dan kotokohan yang dapat menjadikan seseorang untuk menjadi lebih baik. Penelitian ini bertujuan untuk menganalisis tiga bagian utama mengenai sifat shiddiq Rasulullah SAW pada PAUD di TK IT Al-Khair (1) penerapan strategi meneladani sifat shiddiq Rasulullah SAW, (2) membentuk karakter, (3) kendala yang dihadapi dalam strategi meneladani sifat shiddiq Rasulullah SAW. Metode yang dipakai yaitu pendekatan kualitatif dengan memakai studi kasus, dan subjek penelitian yaitu guru wali kelas dan anak-anak berusia 5-6 tahun. Hasil penelitian ini menyatakan bahwa PAUD di TK IT Al-Khair memakai beberapa strategi untuk meneladani sifat shiddiq Rasulullah SAW. Penelitian ini mengikhtisarkan bahwa PAUD di TK IT Al-Khair melakukan kerjasama antara guru dengan orang tua dalam membentuk sifat shiddiq Rasulullah SAW kepada anak. Pembentukan sifat shiddiq Rasulullah SAW pada anak didik tidak hanya tanggung jawab guru dalam pendidikan, tetapi orang tua juga berperan penting dalam hal ini.
Preterm Birth: Thoughtful Strategies for Screening and Management of Risk Factors: A Descriptive Review
Authors: Harris Sarah , Greene Andrew , Downs Sarah , Sakowicz Allie , Quinn Kristen H. , Denney Jeff M.
Published: May 2024

Objective: Preterm delivery remains the leading cause of neonatal morbidity and mortality leading to a burden lasting well beyond the inherent costs of caring for the premature neonate. Physician-scientists, scientists, and clinicians have intensively studied associations, scoured every aspect to determine modifiable risk factors, and trialed prospective interventions to generate best practices. We aimed to generate a useful review for clinicians for the identification of women at risk for preterm birth along with modifiable factors and treatments to help reduce preterm delivery. Mechanism: We performed a literature search for preterm birth prevention to facilitate compilation of a narrative review. Findings in Brief: The PROLONG study found that Makena did not significantly reduce the risk of preterm birth (PTB) <35 weeks among those with a history of PTB <37 weeks; the PTB rate was 11.5% in the placebo group and 11.0% in the 17 alpha-hydroxyprogesterone caproate (17-OHP) group, (relative risk (RR) 0.95, 95% confidence interval (95% CI) 0.71–1.26, p = 0.72) and led to the American College of Obstetricians and Gynecologists to no longer recommend use of Makena for prevention of preterm birth. Nonetheless, a number of tools for screening and behavior modification remain for clinicians to utilize in patient care: (1) alabama Preterm Prevention project showed high negative predictive value of a cervical length in excess of 2.0 cm for delivery preterm birth, particularly in women with prior preterm birth less than 34 weeks (hazard ratio (HR) 2.8, p < 0.0001; RR 2.1, p < 0.0001); (2) treatment of infections; e.g., antibiotic treatment of urinary tract infections may be associated with a reduction in preterm birth (RR 0.34, 95% CI 0.13–0.88); (3) discontinuation of tobacco and illicit drug use given the association of use with preterm birth; and (4) identification of vaginal dysbiosis or pathologic alterations in vaginal flora poses as opportunity to reduce preterm delivery (e.g., bacterial vaginosis confers 2.9 fold increased risk of preterm birth). Conclusions: Many associations and modifiable behaviors and conditions have been identified for the care of the patient at risk for preterm birth. Evidence-based therapeutic intervention includes identification and treatment of nutritional deficits, infections, short cervix, and cervical insufficiency. Future studies on alteration of vaginal microbiome may identify additional therapy to reduce incidence of preterm birth.
Naringin Regulates the Growth and Apoptosis of Ovarian Cancer Cells via the TGF-β Signaling Pathway: A Prospective Laboratory Based Study
Authors: Zhou Xiaoni , Yu Ying , Xie Bingqing , Chen Tingtao , Cai Liping
Published: May 2024

Background: Traditional Chinese medicine (TCM) exhibits anti-tumor capabilities. This study explored the anti-tumor activity of Naringin in ovarian cancer and the signaling mechanism. Methods: The current investigation comprised the administration of various concentrations of Naringin, paclitaxel, and cisplatin to SKOV3 cells. Following the therapy, the protein expression levels for (TGF-β) and its downstream (Snail1)/(SMAD2) were measured in SKOV3 cells. Finally, small interfering RNA (siRNA) targeting TGF-β was synthesized, and the recombinant plasmid vector overexpressing TGF-β was constructed to detect the mRNA and protein expression of Snail1/SMAD2. The results were verified in animal models. Results: In this study, the expression of TGF-β varied significantly with varying Naringin concentrations. The expression of the downstream Snail1/SMAD2 was also affected. With increasing Naringin concentration, the expression of Snail1/SMAD2 decreased gradually in cells. Moreover, overexpressing TGF-β increased the expression of Snail1/SMAD2 and vice versa. In addition, Naringin further decreased the expression of Snail1/SMAD2 produced by transforming growth factor-β (TGF-β). Consistent outcomes were achieved when TGF-β agonists and inhibitors were employed alongside the inclusion of Naringin in animal models. Conclusions: The results of the present study demonstrated that Naringin suppressed the proliferation of ovarian cancer cells in a manner that depended on the dosage and also triggered programmed cell death (apoptosis) in ovarian cancer cells by activating the TGF-β mediated signaling pathway.