bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Advances in the Design and Synthesis of Small Molecule Carbonic Anhydrase IX Inhibitors
Authors: Lv Pengcheng , Cai Yinyi , Luo Jiayi , Chen Kun
Published: February 2022

Human carbonic anhydrase (CA) IX is a tumor-associated protein since it is scarcely pre-sent in normal tissues but highly overexpressed in a large number of solid tumors, where it actively contributes to survival and metastatic spread of tumor cells. A variety of approaches and design strategies were reported that afford CA IX/XII specific inhibitors and avoid the compromising ef-fects of isoforms-promiscuous compounds. CA IX inhibitors hybrids/conjugates have become an important scaffold to design therapeutic agents with both CA inhibition and anti-cancer effects. In this review, we firstly present an overview of the role of CA IX in hypoxic tumors physiopathology, then provide a comprehensive update on the rational design and synthesis of small molecule CA IX inhibitors discovered since 2019. Also, their structure-activity relationship analysis studies are cov-ered. A brief description of applications for CA IX inhibition in other therapeutic areas is also pro-vided.
Aza-BODIPY-based Fluorescent and Colorimetric Sensors and Probes
Authors: Soylukan Caner , Pamuk Algi Melek , Algi Fatih , Sonkaya Ömer
Published: February 2022

Aza-boron-dipyrromethenes (Aza-BODIPYs) represent an important class of chromo-phores absorbing and emitting in the near-infrared (NIR) region. They have unique optical and elec-tronic features and higher physiological and photo stability than other NIR dyes. Especially after the development of facile synthetic routes, Aza-BODIPYs have become indispensable fluors that can find various applications ranging from chemosensors, bioimaging, phototherapy, solar energy materials, photocatalysis, photon upconversion, lasers, and optoelectronics. Herein, we review Aza-BODIPY based fluorescent and colorimetric chemosensors. We show the potential and untapped toolbox of Aza-BODIPY based fluorescent and colorimetric chemosensors. Hence, we divide the fluorescent and colorimetric chemosensors and probes into five sections according to the target ana-lytes. The first section begins with the chemosensors developed for pH. Next, we discuss Aza-BODIPY based ion sensors, including metal ions and anions. Finally, we present the chemosensors and probes concerning reactive oxygen (ROS) and nitrogen species (RNS) along with biologically relevant species in the last two sections. We believe that Aza-BODIPYs are still in their infancy, and they have a promising future for translation from the bench to real biomedical and materials science applications. After two decades of intensive research, it seems that there are many more to come in this already fertile field. Overall, we hope that future work will further expand the applica-tions of Aza-BODIPY in many areas.
The Pivotal Role of Echocardiography in the Diagnosis of Stress-Induced
Cardiomyopathy Presenting with Atypical Pattern in Critically Ill
Children. An Illustrative Case Report
Authors: Rodriguez-Gonzalez Moises , Ramos-Rodriguez Alicia , Fernandez-Bravo Carmen , Estepa-Pedregosa Lorena
Published: February 2022

Background:

Takotsubo cardiomyopathy (TCM) has some distinctive features like greater
proportion of reverse-TCM and central nervous system disease as a prevalent triggering cause. We
expose the case of a child with cardiogenic shock presenting an atypical echocardiographic TCM pattern
on an echocardiography, after an acute neurologic trigger. We also include a systematic literature
review of previously described cases of atypical-TCM in children.

Case Report:

A previously healthy 9 year-old boy with status epilepticus presented abrupt cardiogenic
shock. The EKG showed signs of myocardial ischemia, cardiac biomarkers NT-proBNP (2756 pg/mL )
and Troponin I (1707 pg/mL ) , and the echocardiography exposed a dilated LV with severely reduced
systolic function (LVEF 28%) along with hypokinetic mid-basal segments (circumferential ballooning),
and preserved hypercontractile apical segments, with the normal origin of both coronary arterial
systems. A presumptive diagnosis of “reverse”, “inverse” or atypical Takotsubo cardiomyopathy was
built based on the echocardiographic findings, apart from the ACS-like EKG findings, the raised cardiac
biomarkers, and the neurological trigger of the hyper catecholaminergic state. Despite cardiovascular
improvement with supportive treatment, the patient eventually expired on day 2 after PICU admission
due to neurological complications. As shown in our systematic review, only 19 similar cases
have been reported to date.

Conclusion:

With the report of this unusual case, we aim to point out the fundamental role of bedside
echocardiography as a diagnostic test for critically ill children presenting with ACS-like in the context
of neurosurgical emergencies, where bedside echocardiography itself can accurately establish a presumptive
diagnosis of TCM.
Retrospective Observational Study to Evaluate Causality, Preventability
and Severity of Adverse Drug Reaction Associated with Anticancer Drugs
in a Tertiary Care Hospital in Northern India
Authors: Sidhu Shabir , Thakur Ravi , Bajaj Jagminder Kaur , Dutta Archana
Published: February 2022

Background:

Chemotherapy has high efficacy, but it is associated with several adverse
drug reactions (ADRs).

Objectives:

A retrospective observational study to explore the prevalence, causality, and preventability
of ADRs of anticancer agents was conducted.

Methods:

The study was carried out at Punjab Institute of Medical Sciences Jalandhar, Punjab after
obtaining IEC approval. The data was collected from cancer patients undergoing treatment at the
hospital. The causality assessment of the collected data was done by using WHO causality assessment
criteria. The preventability and severity of the reported ADRs were also assessed.

Results:

From 50 medical records, a total of 47 ADRs were recorded among 25 patients, out of
which 16 were females and the rest were males. The cancer cases observed were breast carcinoma,
leukaemia, lung, colon, and ovarian cancer. The highest number of ADRs were observed with alkylating
agents, followed by taxanes, antimetabolites, kinase inhibitors, and monoclonal antibodies.
The most affected organ systems were the gastrointestinal system, blood, and lymphatic system.
According to the causality assessment, the majority of the ADRs were of the "possible" category.
Preventability analysis showed that 85.11% of ADRs were unavoidable reactions, while
14.89% of ADRs were possibly avoidable. Severity analysis of ADRs showed that 87.23% of
ADRs were mild and 12.77% were of moderate severity. The majority of the ADRs were unavoidable
and mild to moderate in severity.

Conclusion:

Since the majority of the ADRs were of the unavoidable category, it indicates that the
treatment regimens are acceptable as per the current clinical management of cancer patients.
Etiology and Antimicrobial Resistance Profile of Superficial Pyogenic
Infections from a Tertiary Care Hospital, Western Rajasthan, India
Authors: Nag Vijaya Lakshmi , Kombade Sarika P. , kaur Navneet , Singh Shambhavi
Published: February 2022

Background:

Superficial pyogenic infection (SPI) is the type of a pyogenic infection, which
involves the infections of the skin, subcutaneous tissue, and soft tissue. These infections can cause
significant morbidity. Antimicrobial resistance (AMR) has emerged due to the rampant use of broadspectrum
agents in superficial pyogenic infections.

Objective:

The aim of the study was to identify the microbial profile of superficial pyogenic infections
and study their antimicrobial resistance.

Methods:

A cross-sectional observational study was carried out at the Department of Microbiology of
a tertiary care hospital in the western region of Rajasthan. Samples included pus, aspirate from the
abscess, necrotic tissue, and post-surgical drainage from infected skin at different sites of the patients
attending OPD or admitted in IPD and ICU of the hospital. Identification of isolates was carried out by
standard bacteriological techniques. The antibiotic susceptibility testing (AST) of bacterial isolates was
done by Kirby Bauer disk diffusion method on Mueller Hinton agar (HiMedia, India), and in a few
cases, by automated Microscan system as recommended by the Clinical and Laboratory Standards
Institute (CLSI), Wayne, USA.

Result:

A total of 2283 various specimens were obtained from different areas of healthcare facilities.
Pathogenic bacterial isolates were recovered from 303 specimens. Staphylococcus aureus and
Escherichia coli were found to be the main offenders. The effective antibiotics for gram-positive isolates
were clindamycin, cotrimoxazole, linezolid, tetracycline, and vancomycin, and for gram-negative
bacteria, meropenem, imipenem and amikacin were seen to be effective.

Conclusion:

This study can help formulate a local antibiotic policy which will restrict the unsupervised
antibiotic use and strengthen antibiotic stewardship practices in the hospitals.
Neuroanesthesia Management in Pediatric with Traumatic Brain Injury in Emergency Operation
Authors:   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Regional General Hospital, Surakarta, Dewi Fitri Hapsari , Fatahillah Achmed Rizal ,   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Sebelas Maret University, Dr. Moewardi Regional General Hospital, Surakarta
Published: February 2022

Background: Pediatric neuroanaesthesia is an exciting and challenging branch of anaesthesia. Because the anatomy and physiology of the neurological system of children are still immature, the management of neuroanaesthesia in children is different from that of adults, from hemodynamic control, selection of anaesthetic drugs used, to endotracheal intubation. Case: In this case report, we report a 1-month-old male infant, weighing 4.6 kg, with a diagnosis of acute on chronic SDH in the frontotemporoparietal region. Physical examination revealed a decrease in consciousness GCS E2V2M5, with a pulse of 157 times per minute, a respiratory rate of 48 times per minute and a 100% SpO2 with oxygen administration of 2 litres per minute through a nasal cannula. On examination of the airway, there was no gurgling, snoring, or hoarseness. The patient was hemodynamically stable during the 90-minute operation. Postoperatively the patient was admitted to the PICU. Conclusion: Anaesthesia treatment for traumatic brain injury in infants has unique problems that require knowledge of the anatomy and physiology of the pediatric brain.
Digital and Mobile Health Technology in Collaborative Behavioral Health Care: Scoping Review (Preprint)
Authors: Moon Khatiya , Sobolev Michael , Kane John M
Published: February 2022

BACKGROUND

The collaborative care model (CoCM) is a well-established system of behavioral health care in primary care settings. There is potential for digital and mobile technology to augment the CoCM to improve access, scalability, efficiency, and clinical outcomes.

OBJECTIVE

This study aims to conduct a scoping review to synthesize the evidence available on digital and mobile health technology in collaborative care settings.

METHODS

This review included cohort and experimental studies of digital and mobile technologies used to augment the CoCM. Studies examining primary care without collaborative care were excluded. A literature search was conducted using 4 electronic databases (MEDLINE, Embase, Web of Science, and Google Scholar). The search results were screened in 2 stages (title and abstract screening, followed by full-text review) by 2 reviewers.

RESULTS

A total of 3982 nonduplicate reports were identified, of which 20 (0.5%) were included in the analysis. Most studies used a combination of novel technologies. The range of digital and mobile health technologies used included mobile apps, websites, web-based platforms, telephone-based interactive voice recordings, and mobile sensor data. None of the identified studies used social media or wearable devices. Studies that measured patient and provider satisfaction reported positive results, although some types of interventions increased provider workload, and engagement was variable. In studies where clinical outcomes were measured (7/20, 35%), there were no differences between groups, or the differences were modest.

CONCLUSIONS

The use of digital and mobile health technologies in CoCM is still limited. This study found that technology was most successful when it was integrated into the existing workflow without relying on patient or provider initiative. However, the effect of digital and mobile health on clinical outcomes in CoCM remains unclear and requires additional clinical trials.
Online Health Information Seeking Behaviors Among Older Adults: Systematic Scoping Review (Preprint)
Authors: Zhao Yuxiang Chris , Zhao Mengyuan , Song Shijie
Published: February 2022

BACKGROUND

With the world’s population aging, more health-conscious older adults are seeking health information to make better-informed health decisions. The rapid growth of the internet has empowered older adults to access web-based health information sources. However, research explicitly exploring older adults’ online health information seeking (OHIS) behavior is still underway.

OBJECTIVE

This systematic scoping review aims to understand older adults’ OHIS and answer four research questions: (1) What types of health information do older adults seek and where do they seek health information on the internet? (2) What are the factors that influence older adults’ OHIS? (3) What are the barriers to older adults’ OHIS? (4) How can we intervene and support older adults’ OHIS?

METHODS

A comprehensive literature search was performed in November 2020, involving the following academic databases: Web of Science; Cochrane Library database; PubMed; MEDLINE; CINAHL Plus; APA PsycINFO; Library and Information Science Source; Library, Information Science and Technology Abstracts; Psychology and Behavioral Sciences Collection; Communication & Mass Media Complete; ABI/INFORM; and ACM Digital Library. The initial search identified 8047 publications through database search strategies. After the removal of duplicates, a data set consisting of 5949 publications was obtained for screening. Among these, 75 articles met the inclusion criteria. Qualitative content analysis was performed to identify themes related to the research questions.

RESULTS

The results suggest that older adults seek 10 types of health information from 6 types of internet-based information sources and that 2 main categories of influencing factors, individual-related and source-related, impact older adults’ OHIS. Moreover, the results reveal that in their OHIS, older adults confront 3 types of barriers, namely individual, social, and those related to information and communication technologies. Some intervention programs based on educational training workshops have been created to intervene and support older adults’ OHIS.

CONCLUSIONS

Although OHIS has become increasingly common among older adults, the review reveals that older adults’ OHIS behavior is not adequately investigated. The findings suggest that more studies are needed to understand older adults’ OHIS behaviors and better support their medical and health decisions in OHIS. Based on the results, the review proposes multiple objectives for future studies, including (1) more investigations on the OHIS behavior of older adults above 85 years; (2) conducting more longitudinal, action research, and mixed methods studies; (3) elaboration of the mobile context and cross-platform scenario of older adults’ OHIS; (4) facilitating older adults’ OHIS by explicating technology affordance; and (5) promoting and measuring the performance of OHIS interventions for older adults.
Consumer Commitment in Bosnia and Herzegovina to Electronic or Traditional Purchase
Authors: Aleksandra, PhD Vidovic
Published: February 2022

The subject of the research refers to the attitudes and commitment of consumers to the usual or electronic shopping in Bosnia and Herzegovina. The aim of this paper is to investigate how much electronic is used in Bosnia and Herzegovina in relation to the usual purchase, i.e.. to what extent e-shopping is accepted in these areas, also another goal is to determine the factors that influence their behaviour in e-shopping. The purpose of this research was to determine the extent to which there is interest in this form of shopping in Bosnia and Herzegovina. The research was conducted so that the following hypotheses can be tested on a selected sample: H0-Customers in Bosnia and Herzegovina prefer traditional over online shopping.
Numerical and physical modeling of wind loads on long-span shell structures
Authors: Lampsi Boris B. , Shilov Sergey S. , Khazov Pavel A.
Published: February 2022

Introduction. Wind load has a significant impact on buildings and structures. It triggers the evolution of the stress-strain state that causes various kinds of deformations. Requirements, applicable to the serviceability limit state, are important for the construction of long-span structures. In some cases, the analysis of the distribution of wind effects over the surface of a construction facility may be a challenging task. The purpose of the study is to identify the pattern of the wind load distribution over the shell of a long-span structure using physical and numerical methods, compare and analyze the obtained results.

Materials and methods. In the course of the study, a model of the shell structure was tested in the wind tunnel in the course of the physical testing. The model was made of polymer materials using the 3D printing technology. In addition, the article addresses the procedure for conducting full-scale tests in a wind tunnel. Numerical modeling was performed using various software and numerical software packages, such as Ansys CFX, SOLIDWORKS.

Results. The article presents the results of physical tests conducted in a wind tunnel, demonstrates the tables that have the values of aerodynamic coefficients and wind pressures, on the basis of which colour pressure isofields are made. Also, the article presents the results of iterative calculations of numerical models made using various software and numerical software packages. In addition, wind flow distributions were analyzed, since the object of the study has such a characteristic feature as an open-air shell, which allows the air flow to reach the structure from below.

Conclusions. The authors analyzed the data obtained as a result of the research; the convergence between the results of physical tests and numerical modeling in Ansys CFX was identified, a great discrepancy between numerical and physical studies was identified as a result of the application of other software packages. When designing buildings and structures, having intricate geometric shape, both physical and numerical modeling should be conducted.
B-spline wavelet discrete-continual finite element method for the local solution to the two-dimensional problem of the theory of elasticity
Authors: Akimov Pavel A. , Mozgaleva Marina L.
Published: February 2022

Introduction. The distinctive article presents a local semi-analytical solution to the problem of the two-dimensional theory of elasticity. The corresponding structures, featuring the regularity (constancy) of physical and geometric parameters (the modulus of elasticity of the material of the structure, the Poisson’s ratio of the material of the structure, dimensions of the cross section of the structure) along one direction (dimension) are under consideration. This direction is conventionally called the basic direction.

Materials and methods. The B-spline wavelet discrete-continual finite element method (DCFEM) is used. The initial ope­rational formulation of the problem was constructed using the theory of distribution and the so-called method of extended domain, proposed by Prof. Alexander B. Zolotov.

Results. Some topical issues of construction of normalized basis functions of a B-spline are considered, the approximation technique for corresponding vector functions and operators within DCFEM is described. Along the basic direction, the problem remains continual and an exact analytical solution can be obtained, while along the non-basic direction the finite element approximation is used in combination with a wavelet analysis apparatus. As a result, we can obtain a discrete-continual formulation of the problem. Thus, we have a multi-point (in particular, a two-point) boundary problem for the first-order system of ordinary differential equations with constant coefficients. A special correct analytical method for the solution of such problems was developed, described and verified in numerous papers written by the authors. In particular, we consider the simplest sample analysis of a deep beam, fixed along the side faces and subjected to the load concentrated in the centre of the structure.

Conclusions. The solution to the verification problem obtained using the proposed version of the wavelet-based DCFEM was in good agreement with the solution obtained using a conventional finite element method (corresponding solutions were constructed with localization and without localization; these solutions coincide almost completely, while the advantages of the numerical-analytical approach are quite obvious). It is shown that the use of B-splines of various degrees within the wavelet-based DCFEM leads to a significant reduction in the number of unknowns.
Changes in the initial parameters of waves caused by distortions in the scale of a hydraulic model
Authors: Shelushinin Yuriy A.
Published: February 2022

Introduction. The distorted scale method is often used to develop physical models of hydraulic structures. Notably, scientific researches concerning the methodology of distortions are quite rare, especially those that are focused on the modeling of wind waves. In the modern practice, scale distortions only affect the underwater topography and hydraulic structures. In this case, initial waves remain unchanged, and this can lead to errors in the wave mode at the control points of a model. Given the data on errors, the author considers the changes in the parameters of initial waves, if the scale of a physical model is distorted.

Materials and methods. The author used methods of physical and numerical modeling. Experimental studies were conducted in a wave flume and a wave pool that had a wavemaker. In the course of the experiments, the initial wave mode was changed and the parameters of waves were measured at the control points of distorted physical models. Numerical mode­ling was employed to analyze the computational patterns similar to the physical models.

Results. The author used physical models featuring varying degrees of distortion to obtain a collection of the wave mode data under the conditions of the wave transformation and diffraction. Physical and numerical modeling results are compared. The author provides an assessment of the results attained by changing the parameters of initial waves and distorted physical models.

Conclusions. The scale distortion triggers changes in the wave mode that may not be easy to control and correct. This fact must be taken into account when distorted hydraulic models are developed. This approach demonstrates varying efficiency if applied to different physical models featuring characteristic processes.
Justification of the optimal base choice for the anti-filtration circuit during the reclamation of toxic waste storage facilities
Authors: Solsky Stanislav V. , Kotlov Oleg N. , Sobkalov Fedor P.
Published: February 2022

Introduction. Storage facilities, designated for the toxic production waste and located on the premises of the former Sredne-Volzhsky chemical plant in Chapayevsk, Samara Region, are sources of negative environmental impacts. The situation is aggravated by the lack of a reliable seepage prevention circuit at toxic waste storage facilities, enclosed by natural impermeable layers. The purpose of the study is to substantiate the choice of the optimal base for seepage prevention curtains along the perimeter of toxic waste storage facilities by clarifying the filtration characteristics of impervious soils using the interpretation of special experimental filtration works, followed by the testing of the effectiveness of engineering solutions using the developed geological filtration model.

Materials and methods. Processing Modflow is the software designed for the 3D filtration and pollutant transport modeling. The input data for a geological filtration model included technical reports on engineering surveys conducted in 2013 on the premises of the former Sredne-Volzhsky chemical plant, as well as the results of special experimental and filtration works and plant site level observations interpreted using the ANSDIMAT software.

Results. The filtration characteristics of the clay rocks of Upper Quaternary deposits were clarified as a result of the interpretation of special experimental and filtration works by the ANSDIMAT software through graphic analytical methods, and the application of a numerical model by the Processing Modflow software to imitate these works. The resulting characteristics confirmed the usability of this engineering geological element as the base for the designed anti-seepage curtains. The Processing Modflow software was applied to confirm the high efficiency of the filtration prevention circuit, which allowed to significantly reduce inflows in toxic waste storage facilities in the course of their reclamation.

Conclusions. In the process of reclamation of the area, occupied by the former Sredne-Volzhsky chemical plant, the option, recommended for implementation, is the installation of anti-seepage curtains around the perimeter of the toxic waste storage facilities for the circuit to be enclosed by the clay rock of the Upper Quaternary deposits. The proposed engineering solution will allow the highly toxic filtrate to be concentrated inside the toxic waste storage facilities to prevent its penetration into the environment.
Hierarchy of correlation quantifiers comparable to negativity
Authors: Ganardi Ray , Miller Marek , Paterek Tomasz , Żukowski Marek
Published: February 2022

Quantum systems generally exhibit different kinds of correlations. In order to compare them on equal footing, one uses the so-called distance-based approach where different types of correlations are captured by the distance to different sets of states. However, these quantifiers are usually hard to compute as their definition involves optimization aiming to find the closest states within the set. On the other hand, negativity is one of the few computable entanglement monotones, but its comparison with other correlations required further justification. Here we place negativity as part of a family of correlation measures that has a distance-based construction. We introduce a suitable distance, discuss the emerging measures and their applications, and compare them to relative entropy-based correlation quantifiers. This work is a step towards correlation measures that are simultaneously comparable and computable.
The refined quantum extremal surface prescription from the asymptotic equipartition property
Authors: Wang Jinzhao
Published: February 2022

Information-theoretic ideas have provided numerous insights in the progress of fundamental physics, especially in our pursuit of quantum gravity. In particular, the holographic entanglement entropy is a very useful tool in studying AdS/CFT, and its efficacy is manifested in the recent black hole page curve calculation. On the other hand, the one-shot information-theoretic entropies, such as the smooth min/max-entropies, are less discussed in AdS/CFT. They are however more fundamental entropy measures from the quantum information perspective and should also play pivotal roles in holography. We combine the technical methods from both quantum information and quantum gravity to put this idea on firm grounds. In particular, we study the quantum extremal surface (QES) prescription that was recently revised to highlight the significance of one-shot entropies in characterizing the QES phase transition. Motivated by the asymptotic equipartition property (AEP), we derive the refined quantum extremal surface prescription for fixed-area states via a novel AEP replica trick, demonstrating the synergy between quantum information and quantum gravity. We further prove that, when restricted to pure bulk marginal states, such corrections do not occur for the higher Rényi entropies of a boundary subregion in fixed-area states, meaning they always have sharp QES transitions. Our path integral derivation suggests that the refinement applies beyond AdS/CFT, and we confirm it in a black hole toy model by showing that the Page curve, for a black hole in a superposition of two radiation stages, receives a large correction that is consistent with the refined QES prescription.
Masowe dobra luksusowe - kreowanie wizerunkumarki za pomocą narzędzi marketingu online
Authors:   Uniwersytet Ekonomiczny w Katowicach, Wydział Ekonomii, Polska, Wajnbrener Sylwia
Published: February 2022

Abstract: Promoting mass luxury goods on the Internet is a new topic, but it is rapidly gaining in popularity. Factors that influence the growing interest in this medium are tools that facilitate the promotion, sales, and acquiring knowledge about customers and market trends, as well as a global reach. The marketing of luxury products is characterized by unique rules that are referred to as inverted. This means that it is the opposite of the promotion of mass goods because frequent marketing measures are increasing the price and limiting the availability of products. Inappropriate promotional activities can have consequences that are undesirable by companies, such as loss of luxury or customer reluctance to the brand. The article aimed to identify the specifics of luxury mass goods and related marketing activities carried out on the Internet, as well as to recognize the importance of online marketing in creating and perceiving mass luxury brands customers to do this, primary research was carried out using a questionnaire. After analyzing the results, it was found that this type of marketing has a positive effect on brand recognition among consumers and does not deprive it of its luxurious character. The advertisements in the recipients arouse positive emotions and do not prevent them from buying the products of a given luxury brand. Respondents in particular pay attention to the promo- tion of luxury mass brands using such social media as Facebook and Instagram, and in advertising they notice, above all, the presence of brand ambassadors and graphics. Keywords: luxury goods marketing, online marketing tools. JEL Classification: M310, M370
Mulher, família e negócio: o papel da mulher no sertão da Bahia no século XIX
Authors: Ferreira Novais Idelma Aparecida
Published: February 2022

Este artigo tem por objetivo analisar a participação da mulher na vida socioeconômica da Imperial Vila da Vitória (atual Vitória da Conquista, Ba.), no século XIX. Com base em inventários, testamentos e petições, identificamos algumas funções exercidas pelas mulheres nesse período, entre elas as de proprietárias, produtoras, comerciantes e chefes de família. Essas mulheres sertanejas não se intimidaram com o poder do universo masculino e recorreram à justiça sempre que se sentiram prejudicadas, principalmente nas suas economias. Elas entravam com ações judiciais para pedir o direito de administrar suas fortunas, para se divorciar, pedir a tutela de seus filhos, como, também, defender as suas propriedades de invasores.
Clio política e biografia: relevância da biografia, e seus usos, para a história política.
Authors: Amorim Jorge
Published: February 2022

Desde a década de 1970 a biografia vem dividindo o patamar de mercado com a historiografia, podendo se adequar como um ramo desta última. Diferente do seu uso panegírico, como ocorreu na antiguidade, o estudo biográfico tende a ser complementado pela memória e pela oralidade, ainda mais quando são investigados quadros políticos. As narrativas tradicionais biográficas merecem o diálogo com a história, destacando aquelas de temáticas políticas. Este artigo contribui para a elaboração de uma ótica metodológica importante aos estudos biográficos ao propor uma a maior humanização da pessoa biografada e menos a sua mitificação.
Crime e justiça em Ilhéus, 1839-1843: interpretação de um processo de responsabilidade
Authors: Andrade Marcelo Loyola
Published: February 2022

O artigo analisa o funcionamento da justiça em Ilhéus a partir da investigação de um processo de responsabilidade impetrado contra um major, no ano de 1843. Trata-se de uma pessoa de família rica, que exerceu influência política e socioeconômica em Ilhéus ao longo do século XIX. O objetivo é mostrar os embates e enfrentamentos na construção da justiça no início da década de 1840, quando as reformas do código criminal foram efetuadas. O documento dispõe de informações que permitem conhecer determinados aspectos do poder judiciário na instância local, seos limites e o alcance de seu funcionamento e a ligação com os projetos elaborados no bojo da construção do Estado imperial brasileiro.
Recombinant Limosilactobacillus (Lactobacillus) delivering nanobodies against Clostridium perfringens NetB and alpha toxin confers potential protection from necrotic enteritis
Authors: Gangaiah Dharanesh , Ryan Valerie , Hoesel Daphne van , Mane Shrinivas , McKinley Enid , Lakshmanan Nallakannu , Reddy Nandakumar , Dolk Edward , Kumar Arvind
Published: February 2022

Necrotic enteritis (NE), caused by Clostridium perfringens, is an
intestinal disease with devastating economic losses to the poultry
industry. NE is a complex disease and predisposing factors that
compromise gut integrity are required to facilitate C. perfringens
proliferation and toxin production. NE is also characterized by drastic
shifts in gut microbiota; C. perfringens is negatively correlated with
Lactobacilli. Vaccines are only partially effective against NE and
antibiotics suffer from the concern of resistance development. These
strategies address only some aspects of NE pathogenesis. Thus, there is
an urgent need for alternative strategies that address multiple aspects
of NE biology. Here, we developed Limosilactobacillus (Lactobacillus)
reuteri vectors for in situ delivery of nanobodies against NetB and α
toxin, two key toxins associated with NE pathophysiology. We generated
nanobodies and showed that these nanobodies neutralize NetB and α toxin.
We selected L. reuteri vector strains with intrinsic benefits and
demonstrated that these strains inhibit C. perfringens and secrete over
130 metabolites, some of which play a key role in maintaining gut
health. Recombinant L. reuteri strains efficiently secreted nanobodies
and these nanobodies neutralized NetB. The recombinant strains were
genetically and phenotypically stable over 480 generations and showed
persistent colonization in chickens. A two-dose in ovo and drinking
water administration of recombinant L. reuteri strains protected
chickens from NE-associated mortality. These results provide
proof-of-concept data for using L. reuteri as a live vector for delivery
of nanobodies with broad applicability to other targets and highlight
the potential synergistic effects of vector strains and nanobodies for
addressing complex diseases such as NE.
Evaluation and improvement of soil water characteristic curves through in-situ monitoring data in the plains
Authors: Zhang Pingnan , Wang Chuanhai , Chen Gang , Zheng Shiwei , Yu Yue , Li Youlin , Li Xiaoning
Published: February 2022

In the agricultural area of humid plains, soil water migration and
exchange events are frequent and disruptive. Studies on the soil water
characteristic curve (SWCC) of unsaturated zones show they are
significantly impacted by regional water cycles. In this study, a
variety of hydrological data parameters such as rainfall, evaporation,
soil water content, and groundwater level were continuously collected
for Jintan experimental site in the plains of Taihu Basin, China. The
observation results show that the soil water content changes drastically
in the flood season every year, with the occurrence of obvious
absorption and desorption processes. In terms of soil water content, the
soil layer corresponding to a depth of 0-40 cm below the ground is the
zone that is most frequently and severely altered. The SWCC based on
field data was obtained through numerical inversion of soil water
characteristic parameters in a numerical code (HYDRUS-1D). Compared with
those measured in the laboratory, the field measured curves in each
depth range are more consistent with the characteristics of silty clay
loam. The SWCC from field data and the laboratory data were each applied
to simulate soil water content for different depths in precipitation
events. The simulation results based on the field data showed
significantly better correspondence than the results of the laboratory
simulation and were more consistent with the changes in soil water
content measured in the field.
Repair of double orifice mitral valve with an atrioventricular septal defect in a girl with Ellis-Van Creveld syndrome
Authors: Al-Dairy Alwaleed , Srour Samir , Chaker Alaa , Hasan Fatimah Alzahraa Alsyed
Published: February 2022

Ellis–van Creveld syndrome is a rare autosomal recessive disorder. We
describe the case of a 7-year-old girl with Ellis–van Creveld Syndrome
with the diagnosis of common atrium and partial atrioventricular septal
defect. She underwent a successful surgical repair, and
intraoperatively, a double orifice mitral valve was diagnosed as well.
Citibike and Gender Trip Duration
Authors: Kasem Alia
Published: February 2022

This analysis will be focusing on Citibike ridership in terms of total
trip duration based on male and female usage per miles and minutes. The
study data period for this project from January 2016 to December 2016.
The data explore the trip duration for citibike. The Null Hypothesis,
the female duration is higher or equal to the male trip. The analysis
relied on uses the T-testing as a statistical method to test the two
means of samples.
Cross clinical-experimental-computational qualification of in silico drug trials on human cardiac Purkinje cells for proarrhythmia risk prediction
Authors: Trovato Cristian , Mohr Marcel , Schmidt Friedemann , Passini Elisa , Rodriguez Blanca
Published: February 2022

Background and Purpose Preclinical identification and understanding of
drug-induced cardiotoxicity is still a major challenge. The ICH S7B Q&A
promote human in silico drug trials for proarrhythmia risk assessment.
However, additional evidence is needed to support further regulatory
impact and for their integration in the current preclinical assessment
pipelines. This study aims to provide a comparative evaluation of
drug-induced electrophysiological effects on in silico and in vitro
cardiac Purkinje and to assess the accuracy of these models for clinical
risk predictions. Experimental Approach The effects of 14 reference
compounds were quantified in a population of in silico human cardiac
Purkinje models, and compared with results obtained in in vitro rabbit
Purkinje preparations. For each drug dose, five electrophysiological
biomarkers were quantified at three pacing frequencies, and results
compared with clinical proarrhythmia reports. Key Results i) In silico,
repolarisation abnormalities in human Purkinje simulations predicted
drug-induced arrhythmia for all risky compounds, showing higher
predicted accuracy than rabbit experiments; ii) Drug-induced
electrophysiological changes observed in human-based simulations showed
a high degree of consistency with in vitro rabbit recordings at all
pacing frequencies, and depolarisation velocity and action potential
duration were the most consistent biomarkers; iii) discrepancies
observed for dofetilide, sotalol and terfenadine are mainly caused by
species differences between humans and rabbit. . Conclusion and
Implications In this study we showed the high degree of consistency and
higher accuracy of in silico methods compared to in vitro animal models,
demonstrating the high regulatory impact of in silico trials for
proarrhythmia prediction.
«ud for at lære husholdningsfag». Om etableringen av husstellundervisning i Norge
Authors: Kvaal Stig
Published: February 2022

The chapter shows how a new ideal of the housewife emerged during the nineteenth century, and how many actors worked to strengthen the knowledge base for the Norwegian food scene. During the second half of the nineteenth century, science became an increasingly more central provider of knowledge and authority in dietary matters, and this led to claims that housekeeping education and schools should be established for young Norwegian women. The authorities also had to be persuaded to include housekeeping education in the primary school curricula. Pioneers used several channels to mission for the cause and mediated it in various ways: as a nutritional issue and question regarding the national economy, as women’s liberation, and as modernization and scientification. The establishment of schools for housewives-to-be, a teacher-training school in household science, and the emergence of school kitchens in primary schools in 1908 were milestones in the professionalization of the housewife’s role and led to improvements in household cooking and the scientification of teaching.
Ekte eller falsk? Kampen om vaniljesmaken og merking av industrielt produsert mat
Authors: Stokland Håkon B.
Published: February 2022

This article shows how cultural constructions of food can have a relatively direct impact on food policy, and thus form an important part of the mediation processes associated with the integration of new, synthetic products into our food systems. Since 2010, food product labeling in Norway has received far greater attention than before – from politicians, the regulatory authorities, manufacturers, consumer organizations and consumers. The regulation and practical handling of labeling has also become considerably more stringent. The article argues that this trend should be seen in the context of changes in the cultural understandings of “authentic” and “fake” food in the preceding decade.

During the 2000s, many Norwegians gained a new understanding of vanilla. The previously appreciated vanilla flavor we knew from vanilla sugar, vanilla ice cream and vanilla sauce was revealed to be from industrially produced, artificial vanillin. Not only did this substance have no connection to the vanilla orchid, from which real vanilla derives, vanillin was to a great extent produced from the by-products of the paper industry and crude oil. These new understandings – or cultural constructions – can be seen in the context of an evolving international critique of modern and industrial food production. In this discourse, industrialized food products are construed as unnatural and false if presented as “ordinary” food. This article examines how new understandings of vanilla flavoring emerged and increased in importance and scope in Norway in the period after the year 2000. Furthermore, it argues that these cultural constructions were decisive in making the regulation and practice of food labeling stricter and subject to greater scrutiny in the following decade.
Mediation Function of Desired Quality of Life Between Place-Making and Liveable Communities in African Cities
Authors: Medayese Samuel , Chipingu Hangwelani Magidimisha , Chipungu Lovemore
Published: February 2022

The challenges which confront urban spaces in developing countries have become so enormous, and they continue to challenge the capacity of States in these countries to respond effectively. These challenges range from poor infrastructure to weak infrastructure governance systems, which has created urban liveability differentials within these Cities across Africa. Therefore, this paper examines the mediation role of Desired Quality of life between Place-making and Liveable communities in Africa using a partial least squares path analytic method. This study employed the use of a questionnaire to investigate the desired Quality of life criteria, the place-making preferences, and the focus of liveable communities within these African Cities through an online Google form survey, posted through social media outlets to different respondents across various cities in Africa. The Snowball technique was employed to achieve sampling of 390 respondents across Africa. The responses obtained were synthesized and analyzed using a path analytic approach; the paper examines the relationship between the study's constructs. The data analysis findings show that place-making indeed influences Liveable communities, and Desired Quality of life mediates the relationship between place-making and liveable communities. The results indicate that Cities that prioritize Quality of Life and place-making have better liveable community spaces over those that do not. The study findings have implications for Liveable communities, as it could help city development planners to acknowledge the influence of Quality of life on Placemaking and liveable communities. The study contributes to the current debate on measuring urban Livability within the African City Space by creating a set of desired indicators that suit the African setting's needs regarding City infrastructure planning and provision.
Conversaciones no patrimoniales para desordenar el futuro
Authors: Barbieri Ariel , Serrano Javier
Published: February 2022

El artículo que aquí se presenta es el resultado de conversaciones digitales entre un antropólogo y un semiólogo en tiempos de pandemia, condiciones de producción inéditas por la relación que puede existir con el tema mismo de este artículo ya que, en este contexto de barbijos y aislamiento, se renueva el vínculo entre la herencia y el futuro de la humanidad.

En este sentido, las preguntas que surgen en este intercambio son apenas intentos para establecer algunos criterios con los cuales situar un discurso sobre el patrimonio que, a partir de considerar los alcances conceptuales de la imaginación y su práctica, logre desandar el camino que cierta cronología occidental había establecido para, de esta manera, abrir otras cosmovisiones, posibilidades no patrimoniales y nuevos modos de hacer el tiempo, la historia y la memoria. Operaciones estéticas de nuevas ciudadanías que entienden que el futuro puede no tener un horizonte tan preciso.
Contar desde la trinchera, lo que el virus nos legó
Authors: Melfi Gustavo
Published: February 2022

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Cultura Pop
Authors: Díaz Larrañaga Nancy
Published: February 2022

Pocos/as pueden detenerse sobre las prácticas cotidianas y repreguntarse sobre sus sentidos y densidad cultural como lo hacen Leonardo Murolo e Ignacio Del Pizzo en el libro “Cultura Pop. Resignificaciones y celebraciones de la industria cultural en el siglo XXI”. Mezcla de familiaridad temática con espesor conceptual; mixtura de puro presente con nostalgia y pasado; ensamble de sujetos, apropiaciones, uso y tecnologías. Todo esto y mucho más nos ofrece el libro editado por Prometeo