bluuebunny/crossref_metadata_2025 huggingface dataset:
KONVERGENSI MAKNA KATA BERSINONIM DALAM AL QUR’AN
Authors: Mukhlas Moh. Mukhlas
Published: March 2018

Abstract: Qur'an is a miracle that has a deep meaning and none can replace those structures, removing or adding words, because each word has a miracle. In Qur'an, there is an interesting phenomenon such meaning convergent that associated with synonymous in context. The aims of this study are to describe and explain the significance of convergence in Qur'an especially synonymous words. Hermeneutic and content analysis were used to analysis those phenomenon. It can be found that convergence of meaning to synonymous words in the Qur'an does not have similar semantic features or same meaning, but there is a shift, changing the meaning, contradictory and meaning resistance. Then the terms of shifts and changing the meaning are as follow (a) the synonymous words that have antonyms meaningful, (b) the synonymous words that have meaningful process, (c) the synonymous words that have depth meaning, and (d) the synonymous words that have deductive-inductive meaning.Keywords: meaning convergent, contextual meaning
MOTIVASI SOSIAL DALAM RITUS TAREKAT QODIRIYAH NAQSABANDIYAH (Studi Ritus Selasan di Masjid Al Bukhori Mojoroto Gelanglor Sukorejo Ponorogo)
Authors: Djohan M. Widda
Published: March 2018

Abstract: Spiritual intelligence (SQ) is the highest intelligence of human beings. There is correlation between spiritual intelligence and Allah. On the other word, someone who has spiritual intelligence should have highest relationship with Allah S. W. T.  Then, its relationship affected interaction among others because of Allah aided. Tarekat Qodiriah wa Naqsyabandia is one of the spiritual activities and it held at Masjid Al Bukhari Mojoroto Gelanglor Sukorejo Ponorogo. This activity is expected to increase spiritual intelligence of the pilgrims.To uncover those phenomenon, this study formulate the problem as follows 1) How is the implementation of Tarekat Qodiriah wa Naqsyabandiah at Masjid Al Bukhori Mojoroto Gelanglor Sukorejo Ponorogo ? 2) How are the pilgrims whose join Tarekat Qodiriah wa Naqsyabandiah at Masjid Al Bukhori Mojoroto Gelanglor Sukorejo Ponorogo? 3) What are the roles of Tarekat Qodiriah wa Naqsyabandiah to increase spiritual intelligence of the pilgrims in Pondok Pesantren Darul Ulum Poncol, Magetan?. This study conducted Descriptive Qualitative approach. Interview, observation, documentation were used to collect the data.Those found that (a) the implementation of Tarekat Qodiriah wa Naqsyabandiah at Masjid Al Bukhari Mojoroto Gelanglor Sukorejo Ponorogo is held thirty-five a days on Minggu (Sunday) Wage.  Furthermore, their activities are dzikir, istighosah, khususiah, reviewing Kitab, and manaqib. (b) There are diverse social stratification of the followers such high, low, and medium stratum.  They are almost 30 years old. (C) The activities of Tarekat Qadiriah wa Naqsabandiah at Masjid Al Bukhari Mojoroto Gelanglor Sukorejo Ponorogo have important roles in increasing Spiritual Intelligence, because the main sets of this activity provides one’s moral and social intelligences, able to manage themselves and have good relationship among others. Those are based on human faith and devotion.Keywords: Spiritual Intelligence (SQ), Tarekat Qodiriah wa Naqsyabandiah
PARADIGMA TAFSIR AL-MANAR
Authors: Saifullah Saifullah
Published: March 2018

Abstract: The essential of Al-Mana>r in the process of interpretation become its interpretation phenomenal. Many names were given indistinguishing al-Mana>r style such al-manhaj al-ijtima>y, al-laun al-adaby al-ijtima>’y and so forth.  The writer elaborates the paradigm that used by al-mana>r’s author to investigate the reasons in giving various naming. As the result, those naming are understandable. This article investigated al-Mana>r paradigm into three perspectives. First, interpretation means an earnest effort which implemented to decide some cases which are not discussed in Qur’an and hadist. In consequence, human taught becomes an important aspect in interpreting. Second, all the effort is an attempt to make the interpretation of Qur’an as guidance (hida>yah). Then third, interpretation effort is an attempt to make Qur'an readers happiness in this world and in the hereafter. Al-Mana>r has inspired various interpreting works. Therefore, Al-Mana>r refers to the social interpreting (al-madrasah al-'aqliyah al-ijtima>'iyyah). Al-Mana>r paradigm can be categorized as rational paradigm because it puts sense in the important position. Muh}ammad 'Abduh argues that, "Logic is the main principal of Islam. Logical thinking in Islam means a prelude to the true faith” and “Reasoning becomes priority when a literal understanding and logical reasoning clash.” Keywords: Paradigm, Help, Happiness, al-Madrasah.
Diffusion-Dominated Proxy Model for Solvent Injection in Ultra-Tight Oil Reservoirs
Authors: Cronin M. , Emami-Meybodi H. , Johns R. T.
Published: March 2018

Enhanced oil recovery (EOR) by solvent injection offers significant potential to increase recovery from shale oil reservoirs, which are typically between 3 and 7% OOIP. The rather sparse literature on this topic typically models these tight reservoirs based on conventional reservoir processes and mechanisms, such as by convective transport using Darcy's law, even though there is little physical justification for this treatment. The literature also downplays the importance of the soaking period in huff'n'puff

In this paper we propose for the first time a more physically-realistic recovery mechanism based solely on diffusion-dominated transport. We develop a diffusion-dominated proxy model assuming first-contact miscibility (FCM) to provide rapid estimates of oil recovery for both primary production and the solvent huff'n'soak'n'puff (HSP) process in ultra-tight oil reservoirs. Simplified proxy models are developed to represent the major features of the fracture network.

The key results show that diffusion-transport only can reproduce the primary production period within the Eagle Ford shale and model the HSP process well, without the need to use Darcy's law. The mechanism for recovery is based solely on density and concentration gradients. Primary production is a self-diffusion process, while the HSP process is based on counter-diffusion. Incremental recoveries by HSP are several times greater than primary production recoveries, showing significant promise in increasing oil recoveries. We calculate ultimate recoveries for both primary production and for the HSP process, and show that methane injection is preferred over carbon dioxide injection. We also show that the proxy model, to be accurate, must match the total matrix contact area and the ratio of effective to total contact area with time. These two parameters should be maximized for best recovery.
Harvest Management Effects on ‘Tifton 44’ Bermudagrass Phosphorus Removal and Nutritive Value
Authors: Read John J. , Lang David J. , Adeli Ardeshir , Jenkins Johnie N.
Published: March 2018

Core Ideas

The impact of harvest management on forage nutritive value is vital to farm income.

Results validate management practices commonly used but heretofore without statistical basis.

Bermudagrass P removal maximized with prolonged harvest interval and short stubble height.

Forage nutritive value was similar between stubble heights when harvested every 35 d.

Haying bermudagrass [Cynodon dactylon (L.) Pers.] to maximize recovery of P applied in broiler litter may adversely affect forage quality. This 3‐yr study (2005–2007) determined harvest management effects on dry matter (DM) yield, P removal, and forage nutritive value in ‘Tifton 44’ bermudagrass at Noxapater and South Farm, MS. Fertilization annually comprised 8.96 Mg ha−1 broiler litter (as‐is basis) that provided 243 and 122 kg ha−1 of N and P, respectively, supplemented with 67–110 kg ha−1 N (as ammonium nitrate). After an initial harvest in May, forage was harvested at 28‐, 35‐, and 49‐d intervals and at 3‐ and 9‐cm residual cutting heights. Seasonal trends in P removal closely followed those observed for DM yield and short stubble increased yields of DM and P by approximately 31%. Prolonged regrowth and 3‐cm stubble height resulted in the greatest yields of DM and P. Annual P removal at Noxapater did not differ between 35‐ and 49‐d harvest intervals (21.3 vs. 23.0 kg ha−1); whereas it was greatest (P < 0.05) at South Farm for 49‐d intervals (23.9 vs. 25.8 kg ha−1). Prolonged regrowth resulted in crude protein (CP) and in vitro true DM digestibility (IVTDMD) below 95 and 610 g kg−1, respectively, suggesting less forage could be consumed by ruminant livestock. In 2007, CP and IVTDMD levels were greatest for 9‐cm stubble. Tifton 44 bermudagrass receiving litter should be harvested every 35 d and at 3‐cm stubble height to provide the best compromise between DM yield, nutrient removal, and forage nutritive value.
Responses of Intermediate Wheatgrass to Plant Growth Regulators and Nitrogen Fertilizer
Authors: Frahm C. S. , Tautges N. E. , Jungers J. M. , Ehlke N. J. , Wyse D. L. , Sheaffer C. C.
Published: March 2018

Core Ideas

Trinexapac‐ethyl reduces height and lodging in wheatgrass.

Trinexapac‐ethyl increased grain yield when lodging risk was high.

Prohexanedione calcium had no effect on wheatgrass.

Trinexapac‐ethyl can reduce risk of yield losses due to lodging.

Intermediate wheatgrass (Thinopyrum intermedium; IWG), a new perennial grain crop, has the potential to provide ecosystem services while producing food‐grade grain; however, productivity is currently limited by high rates of lodging. Trinexapac‐ethyl (TE) and prohexadione‐calcium (PC) are widely used plant growth regulators (PGRs) for mitigating lodging and improving seed yield in other grass crops. Our objectives were to determine the effects of the PGRs PC and TE, PGR application rate, and nitrogen (N) fertilizer rate (0, 40, 80 kg N ha−1) on IWG lodging, height, and grain and biomass yields. Experiments were initiated in first‐ and third‐year stands at St. Paul and Rosemount, MN. Few effects of PC on IWG height, lodging, or yields were observed, while TE consistently reduced plant height by 10 to 20% and lodging by up to 20% in a year with high lodging risk. Application of TE to IWG at the recommended rate (437 g a.i. ha−1) or higher rates increased grain yields by 65 to 100% when lodging incidence was high, but did not affect grain yields in years with lower lodging risk. While a negative correlation between lodging and grain yields was observed, nitrogen fertilizer affected IWG grain and biomass yields in only one of five site‐years, and there was no interaction between N fertilizer and PGR effects on IWG. Nonetheless, the PGR TE demonstrated the potential to reduce plant height and lodging, thereby increasing IWG yield potential.
DRIFT awareness & prevention: Adding specialty crop maps and data to your communication toolbox
Authors: Romary Craig
Published: March 2018

Commercial specialty and certified organic crops are increasingly found in our agricultural landscape, and many of these crops are often more sensitive to drift from pesticides used in many agricultural settings. This article is intended to increase awareness of the utility of web map services and how these might help you or your customers reduce potential incidents of drift on specialty or pesticide‐sensitive crops. Earn 0.5 CEUs in Integrated Pest Management by reading this article and taking the quiz at www.certifiedcropadviser.org/education/classroom/classes/549.
Phenotypic Variation of Cold Stress Resistance‐Related Traits of White Clover Populations Naturalized in Patagonian Cold Environments
Authors: Vásquez Catalina , Inostroza Luis , Acuña Hernán
Published: March 2018

White clover (Trifolium repens L.) is the main forage legume species in grazing pastures in central, central‐southern, and southern regions of Chile and many other temperate regions of the world. The selection of cold stress resistance genotypes is an important step for breeding cultivars to improve the clover growth curve and extend the grazing season in early spring and autumn. The objective of this work was to phenotypically characterize a population of 192 white clover genotypes selected for cold stress resistance under three contrasting regional winter‐cold conditions (mean daily minimum air temperatures of 2.5, 1.6, and −1.4°C) during the coldest month. An α‐lattice experimental field design was used, with 24 incomplete blocks and two replicates. Morphological, physiological and biochemical traits were evaluated at different dates over three growing seasons from 2013 to 2016. A high degree of variability was found among the genotypes for all the characteristics studied. There was no effect of environment when the experimental sites were considered as a source of variation, but comparison of measurements taken at dates separated by a winter showed that there was a decrease in stolon length and diameter, petiole length, leaflet size, and dry matter accumulation in response to cold conditions. The normalized difference and medium resolution imaging spectrometer terrestrial chlorophyll vegetation indices (NDVI and MTCI, respectively) and water‐soluble carbohydrate concentrations in stolons also varied among genotypes and were affected by winter cold. The high degree of phenotypic variability allows for the use of this population as a genetic source for cold stress resistance in white clover.
A NECESSÁRIA FORMAÇÃO INTEGRAL E HUMANISTA PARA UMA SOCIEDADE COMPROMETIDA COM O TODO
Authors: Simonelli Luiza , Lima Filho Domingos Leite , Dias Nilson Marcos Garcia
Published: March 2018

Neste artigo apresenta-se a trajetória do aprender da humanidade, a quem interessou esse conhecimento, as habilidades desenvolvidas e suas utilidades. Parte-se do pressuposto que todo conhecimento teve sua empregabilidade a serviço de algo ou a alguém, como foi o caso da manufatura e da própria industrialização e, ainda que em nenhum momento da historiografia constata-se a preocupação das estruturas do ensino em aplicar a educação para a formação integral e humanista do homem. O texto demonstra que a educação, mesmo aquela que fragmentou o conhecimento, não deu conta de inserir no cotidiano das pessoas, temas como sustentabilidade e mobilidade harmoniosa e segura. Ambientes tidos como apropriados para disseminar o conhecimento integral e com a visão do todo, a escola ou o trabalho, deixaram a desejar na associação do ensino e trabalho para além desses lugares. Dessa maneira, a tecnologia surge, em momentos da história, com contornos de possíveis soluções para linkar o indivíduo à sociedade com inventos cada vez mais sofisticados do ponto de visto do acesso do “como fazer”, mas não da utilização do aparato, exemplos claros a televisão e o veículo, sendo este último um fetiche ainda nos dias atuais. Por fim, o artigo cuida em demonstrar que num ambiente, tido como um dos mais democráticos, o trânsito, revela o lado menos humanista e o mais individualista do homem e que para frear muitas das suas ações negativas, a própria tecnologia, criada pela inteligência humana deflagra as reprovações e as comprova.
SUJEITOS E EDUCAÇÃO DO CAMPO: As representações do pescador artesanal no currículo.
Authors: Santos Willian Siqueira , Martins de Souza Roberto
Published: March 2018

O presente artigo analisa o processo da educação escolar dos pescadores e pescadoras artesanais na região de Guaraqueçaba, Paraná, através da leitura de seus conflitos e contradições sociais específicos em defesa de sua autodeterminação, enquanto povo tradicional protegido pela legislação nacional. O dissenso se manifesta desde o não reconhecimento pela SEED-PR da identidade étnica e coletiva autodeclarada pelo grupo social, e pode ser verificada pelo método impositivo como foram elaboradas as propostas pedagógicas e pela operacionalização dos documentos escolares que sustentam o fazer pedagógico das referidas “escolas das ilhas”. Para ilustrar e situar as contradições da proposta erigida pela mantenedora consideramos como ponto de partida da análise teórica o debate que aponta a superação do paradigma da educação rural e o entendimento da construção da educação do campo, referida à Educação das Ilhas do Litoral do Paraná, investigando seus limites e avanços. Na perspectiva atual e em contraponto, identificamos a emergência do processo de construção de uma educação escolar específica oriunda do Movimento dos Pescadores Artesanais do Litoral do Paraná – MOPEAR, que propõe a partir do seu protagonismo uma ruptura com o modelo de educação colonizadora operacionalizada atualmente pela SEED.
INDICADORES DE DESEMPENHO COMO ARTEFATOS TECNOLÓGICOS NO CONTEXTO DA CIÊNCIA, TECNOLOGIA E SOCIEDADE
Authors: Amaral Cândida Helena Alves Pereira , Das Neves Gomes Mateus
Published: March 2018

Neste trabalho é possível observar as relações sociais em um estudo de caso através da abordagem metodológica da Teoria Ator-Rede (TAR). Baseado nos direcionamentos de Michel Callon e Bruno Latour analisa-se a necessidade de indicadores de desempenho como artefato informacional utilizado para melhor entendimento das demandas, dar transparência, credibilidade e medir o êxito institucional. Levando em consideração as relações humanas e não humanas e a heterogeneidade dos atores que a compõem através de suas redes de interesses. O objetivo é compreender a importância de indicadores de desempenho como artefatos tecnológicos para a gestão informacional das instituições. É preciso também, levar em conta a importância do controle dos indicadores de desempenho para visão, ampla e integral através de dados estatísticos. A compilação dos dados e a apresentação através de gráficos estatísticos auxilia a visão do todo e a tomada de decisões por parte da administração. A experiência analisada foi realizada na disciplina de estatística do curso de licenciatura de ciências sociais do Instituto Federal do Paraná no ano de 2016. Uma possibilidade de inserir conceitos estatísticos de forma que discentes sentem-se confortáveis e compreendam o conteúdo programático. Dentre os diversos projetos desenvolvidos na disciplina um deles teve como temática analisar o efeito dos programas institucionais na permanência dos estudantes no curso, sobretudo os que estavam economicamente vulneráveis. Os resultados apontam que as Políticas Públicas de fomento financeiro logram êxito no auxílio ao combate à evasão escolar.
Intercostal Space Ossification in a Child with Empyema Thoracis and Rhizomelic Chondrodysplasia Punctata
Authors: Tan Jih Huei , Henry Tan Chor Lip , Vendargon Simon Jerome
Published: March 2018

Please see full text
English, Russian and Russian English in Russia: CLIL and non-CLIL studentsâ€™ opinion in St. Petersburg
Authors: Pavenkova Maria , Pavenkov Oleg , Pavenkov Vladimir
Published: March 2018

English is a Lingua Franca in the many domains. Itsâ€™ spread is a factor and a result of the Expanding Globalization. Â The current conflict between Russia and the West initiates a number of increasing concerns towards the fate and the future of the Russian language, to be more exact, they are under-development, pidginization and uncontrolled influx and spread of the English language. The research was carried out at St- Petersburg University in the period January 2016. CLIL and non-CLIL students from three St-Petersburg universities were asked (N=301).The results of the investigations described main concerns about the fate of Russian and the level of adoption of the Russian variety of English (Russian English).
Nota Fiscal Paulista: principais características percebidas pelos cidadãos paulistas
Authors: Silva Sérgio Roberto da , Silva André Luiz Vequettini da , Simon Fernanda Oliveira , Anunciação Luís Fla¡vio Chaves
Published: March 2018

Em São Paulo, estima-se que 60% dos valores de tributos são sonegados pelo varejo (ROLLI; FERNANDES, 2008). Como resposta, o governo paulista criou o projeto Nota Fiscal Paulista (NFP). Nesse projeto, a identificação do contribuinte, por meio do CPF, gera benefícios financeiros ao contribuinte e assegura o pagamento dos tributos por parte do comerciante. O objetivo deste trabalho foi o de identificar as principais características percebidas pelos cidadãos paulistas com relação ao projeto. A pesquisa contou com os dados de 132 indivíduos, que preencheram um formulário composto por 25 assertivas em formato de escala Likert. No geral, os resultados indicam que os contribuintes aceitam e participam do projeto, mas ainda desconhecem algumas de suas características. A maior forma de ressarcimento dos créditos é pelo depósito em conta corrente e parte dos contribuintes acredita que as informações referentes aos valores de crédito não são repassadas à Receita Federal. Tais resultados buscam contribuir com um estudo sob a óptica dos contribuintes em relação a esse projeto.
A tutela da fauna silvestre como efetivação do direito fundamental ao meio ambiente
Authors: Bortolozi Emerson
Published: March 2018

Esta pesquisa tem por objeto a análise da efetivação do direito fundamental ao meio ambiente sob a ótica da tutela à fauna silvestre, com base na Constituição Federal e em normas infraconstitucionais. Como se sabe, a Constituição de 1988 é um marco importantíssimo na evolução da defesa jurídica do meio ambiente, tendo desencadeado o surgimento de uma ampla legislação voltada à defesa de valores ambientais e, particularmente, da fauna silvestre. A partir da ótica constitucional e da legislação de proteção à fauna silvestre, como a lei que cria a Política Nacional do Meio Ambiente, a Lei que cria o Sistema Nacional de Unidades de Conservação (SNUC), a Lei de Uso Científico de Animais, a Lei de Rodeios e, em especial, a Lei de Proteção à Fauna, que foi recepcionada pela Constituição, é que se compõe o arsenal de ferramentas jurídicas que realizam a efetivação do direito fundamental ao meio ambiente animal. Por meio desse exame, identifica-se que a tutela da fauna silvestre acaba significando forma de efetivação do direito fundamental ao Meio Ambiente.
Energia distribuída proveniente da concentração de energia solar nas universidades do Brasil: um estudo de caso
Authors: ZUCATELLI PEDRO JUNIOR , SALVALAIO LUCAS , Pereira Adan Lucio , Meneguelo Ana Paula
Published: March 2018

O aumento da demanda de energia exige a diversificação das formas de geração de energia. Neste contexto, uma tecnologia que vem ganhando destaque em alguns países é a energia solar concentrada (do inglês, Concentrating Solar Power – CSP) que apresenta um bom potencial no Brasil. O objetivo deste projeto foi analisar o potencial técnico e econômico da geração de eletricidade a partir da implementação de uma usina CSP no Centro Universitário Norte do Espírito Santo - CEUNES, localizado em São Mateus – ES, Brasil. Para esse efeito, foi utilizado o SAM (do inglês, System Advisor Model) para avaliar a produção térmica da energia solar local considerando a variação sazonal da região. Os resultados indicaram que a energia gerada anualmente é mais do que suficiente para suprimir o consumo do CEUNES. Na análise econômica, verificou-se que o projeto é viável a longo prazo.
Estudo da turbulência em anulares concêntricos
Authors: Vaccari Rafaela Fracalossi , Ribeiro Jonathan Martins , Ribeiro Daniel Cunha , Pereira Fábio Assis Ressel , Romero Oldrich Joel
Published: March 2018

O trabalho tem o objetivo de simular numericamente por meio da técnica de dinâmica de fluidos computacional (CFD – computational fluid dynamics) o escoamento monofásico turbulento em uma geometria anular concêntrica. Apresentam-se análises sobre a proximidade dos modelos de turbulência com o perfil de velocidades obtido no trabalho de Nouri et al. (1993) e análises do número de Nusselt para diferentes números de Reynolds. Foram utilizados os modelos de turbulência k-ε enhanced e SST k-ω para os casos estudados, sendo que os modelos apresentaram resultados que não divergiam mais que 7% dos resultados tomados como referência. Também é estudado o efeito no perfil de velocidades turbulento da variação da razão de raios
Oxazolidinones as Chiral Auxiliaries in the Asymmetric 1,4-Conjugate Addition Reaction Applied to the Total Synthesis of Natural Products: A Supplemental Mini-Review
Authors: Zadsirjan Vahideh , Heravi Majid M.
Published: March 2018

Background:

The most frequently used chiral auxiliaries, oxazolidinones (Evans' oxazolidinones)
have been employed in 1,4-congugate addition reactions to α,β-unsaturated carbonyl compounds. Supplementary
to our previous reports in this mini-review, we attempted to underscore the applications of this strategy in
a step (steps) in the total synthesis of some naturally occurring compounds exhibiting diverse biological activities.

Objective:

In this mini-review, we try to underscore the applications of oxazolidinones (Evans’ oxazolidinones)
in 1,4-congugate addition reactions to α,β-unsaturated carbonyl in the total synthesis of some naturally
occurring compounds exhibiting diverse biological activities.

Conclusion:

In spite of well-known superiority of asymmetric catalyzed reactions, the use of auxiliarycontrolled
reactions are still considered as commanding, vital and sometimes as only tools in the generation of
stereogenic centers during the construction of complex molecules and total synthesis of naturally occurring
compounds. The commercial availability, or readily accessibility of a wide variety of chiral amino alcohols as
starting materials to synthesize a wide range of oxazolidinones is the merits of them. In addition, the ease of
removal and subjection to various and diverse stereoselective reactions make oxazolidinones as the ideal and
superior chiral auxiliaries. In this regard, they were successfully used in asymmetric 1,4-conjugate addition reactions
with high stereoselectivities. The high degree of asymmetric induction can be attributed to the rigid
chelation of N-acyloxazolidinones with metal ions, as well as the covering of one face of the system by the
bulkiness of 4-substituent. In summary, in this report, the importance of the applications of chiral oxazolidinones
as suitable chiral auxiliaries in the stereoselective, 1,4-conjugate addition reactions in asymmetric synthesis
and in particular, the total synthesis of naturally occurring compounds and some complex molecules
were underscored. Noticeably, in these total syntheses, this chiral auxiliary is controlling the stereochemistry of
a newly created stereogenic center as well as preserving the configuration of other chiral centers, which already
have been presented in the precursor. General methods have been established for the attachment of the chiral
auxiliary as a moiety to the substrate molecule in high to excellent yields. At the end of these reactions, this
auxiliary can be easily removed leaving various desired reactive motifs for the next step in multi-step synthesis.
Molecular Highlights about Leishmanicidal Activity and Cytotoxicity of Quinoxaline Derivatives: A Combination of Ligand-based QSAR/QSTR Approaches
Authors: Castro Silva Joseph W. , Santos Aline A. , Alencar Filho Edilson B.
Published: March 2018

Background: Leishmaniasis is a neglected tropical disease, considered endemic in almost
98 countries worldwide, with 250 million new cases estimated annually. The usual drugs are
considered toxic, expensive and frequently ineffective, justifying the search for new lead compounds.
We presented here ligand-based classical QSAR study involving the leishmanicidal activity
of quinoxaline derivatives and molecular descriptors of diverse nature, aimed to understand their
molecular activities from a quantitative point of view. Additionally, the cytotoxic activity of the
compounds was also modeled in a QSTR approach, in order to help the design of more active and
safe leishmanicidal compounds.

Methods: Geometry optimizations were performed by semiempirical and DFT quantum-chemical
methods. Molecular descriptors were calculated by E-Dragon online platform and submitted to a
variable selection procedure, using Ordered Predictors Selector algorithm. The best QSAR and
QSTR models were selected by MLR modeling and structure-activity relationships were considered,
in accordance to the successful of the validation parameters.

Results: For leishmanicidal activity, five descriptors were selected as the most important, providing
a robust and predictive QSAR model via Multiple Linear Regression (MLR) (R2 = 0.71, Qloo
2 =
0.60, Qext
2 = 0.76 and rtest = 0.87). On the other hand, cytotoxicity was better related to seven descriptors
in QSTR approach (R2 = 0.77, Qloo
2 = 0.65, Qext
2 = 0.85 and rtest = 0.92). Analysis of descriptors
influences on both activities revealed that there are common features that could be explored
to provide a most leishmanicidal and less cytotoxic compound, at the same time, in order to
design more active and safe compounds.

Conclusion: In establishing of the structure-activity relationships and interpreting the physical
sense of the descriptors, we can conclude that molecules containing sulfoxyl, sulfonyl and halogens
tend to be most active, but molecules with large volumes and electronegative atoms tend to be less
active. In addition, in a very interesting way, we could observe that small molecules containing
sulfoxyl, sulfonyl and halogens tend to be less cytotoxic and larger molecules with fewer atoms of
greater mass and electronegativity than carbon tend to be more cytotoxic. Fortunately, the combination
of these characteristics can be explored in the synthesis and evaluation of new safe derivatives
with better leishmanicidal profile.
Synthesis, Biological Evaluation and Molecular Docking Studies of Novel Trimethoxy-ring Derivatives as BRD4 Inhibitors
Authors: Yang Yan , Yao Zhiyi
Published: March 2018

Background: Bromodomain-containing protein 4 (BRD4) inhibitors synthesized with
trimethoxy-ring refer to a new series of small molecular inhibitors. Currently, BRD4 offers the
potential for research as a cancer therapeutic target. Based on previous studies, 17 trimethoxy-ring
derivatives were designed as novel BRD4 inhibitors.

Methods: All these new compounds were synthesized via the amide reaction. Their structures were
identified by 1H NRM, 13C NRM spectra and HRMS. In vitro antitumor activities of the new compounds
were evaluated by MTT. Molecular docking studies were conducted to explain the binding
interactions of these compounds with BRD4 protein.

Results: A series of novel trimethoxy-ring derivatives were synthesized as BRD4 inhibitors and
screened by testing their inhibition against HCT116, MCF-7, K562 and KMS-1 cell lines. Most of
the newly synthesized compounds exhibited moderate-to-good inhibitory activity against HCT116,
MCF-7, and K562 cell lines, whereas some showed inhibitory activity against the KMS-1 cell line.

Conclusion: Compound 3g demonstrated the most potent anti-tumor activity against breast (MCF-7),
leukemia (K562), multiple myeloma (KMS-1), and colon cancer (HCT116) cell lines.
Real-time Dash Streaming Architecture for Internet of Things Using FBMRWP Model for Medical Videos
Authors: Kalpana Bapana , Parthasarathy Rangarajan
Published: March 2018

Background:

The proposed method uses random adjustments in the online video quality
based on the bandwidth allocated over Dynamic Adaptive Streaming over HTTP (DASH) streaming
service.

Aim:

The main objective is to improve the video quality from DASH-HTTP servers with variable
bandwidth. Here, the system is adjusted dynamically for providing best video quality services
based on the requirement of the user.

Methods:

In order to achieve such objective, the DASH service is assigned with three modules.
Initially, the quality is adjusted dynamically using Fractional Brownian Motion and Random Waypoint
Mobility (FBM-RWP) model. This initial model schedules the packets in sub-streams based
on the priority as per the requirement of the user. The final model uses the Proportional Integral
Derivative (PID) quality control algorithm for the past and future prediction of quality based on
bandwidth allocation. This feedback of quality is used by the FBM-RWP model to prioritize the
packets in the sub-streams. The entire process works by matching the bit rate of video streaming
with the user required quality.

Results:

The technique concentrates mostly on medical videos for improving the live video
streaming in case of medical emergencies. The performance of the proposed method is compared
with the conventional DASH services. The results proved that the proposed method performs better
in terms of reduced error and improved throughput.
Solid Lipid Nanoparticles: A Potential Approach for Drug Delivery System
Authors: Sarangi Babita , Jana Utpal , Palei Narahari N. , Mohanta Guru P. , Manna Prabal K.
Published: March 2018

The therapeutic efficacy of perorally administered drug is often concealed by their poor oral
bioavailability (BA) and low metabolic stability in the gastrointestinal tract (GIT). Most of the newly
discovered drug molecules are of high molecular weight and belong to biopharmaceutical classification
system (BCS) – II. Poor aqueous solubility and high membrane permeability characteristics of BCS –
II drugs limit BA after oral administration. Recently, lipid-based drug delivery (LBDD) systems have
gained much importance due to their ability to improve the solubility and BA of poorly soluble drugs.
Oral delivery of drugs incorporated in solid lipid nanoparticles (SLNs) has gained considerable interest
since the last two decades. SLNs have advantages above the others, as compared to polymer toxicity
which is low, as inexpensive excipients and organic solvents are not used. SLNs offer the possibility to
develop new therapeutics due to their unique size-dependent properties. An attempt to incorporate
drugs into SLNs offers a new prototype in drug delivery system which can be utilized for drug targeting
to specific tissue. This review presents elaborate information of SLNs with their aim, advantages,
challenges and limitations, the principle of formulation, routes of administration and their biodistribution.
It also describes the gastrointestinal absorption and the factors affecting absorption of SLNs from
GIT along with its application.
‘Out There’: Developing a transition pathway for adolescents and young adults with cancer using Experience-Based Co-Design
Authors: Weston Charlotte , Soanes Louise , Chisholm Julia , Wiseman Theresa
Published: March 2018

Experience-based co-design (EBCD) was used in the adolescent and young adult (AYA) oncology setting to develop a transition pathway from hospital for young adults completing cancer treatment. The EBCD methodology provides the opportunity to embed patient experience and input into service design. In this project staff and AYAs identified unmet needs and suggested working packages around psychological support, and provision of information about fertility, work, education, and relationships. Staff identified deficits in knowledge of survivorship issues for AYAs and interest in preparing AYAs for life after treatment.
Understanding the Acceptance of an eHealth Technology in the Early Stages of Development: An End-User Walkthrough Approach and Two Case Studies (Preprint)
Authors: van Velsen Lex , Evers Mirka , Bara Cristian-Dan , Op den Akker Harm , Boerema Simone , Hermens Hermie
Published: March 2018

BACKGROUND

Studies that focus on the acceptance of an electronic health (eHealth) technology generally make use of surveys. However, results of such studies hold little value for a redesign, as they focus only on quantifying end-user appreciation of general factors (eg, perceived usefulness).

OBJECTIVE

We present a method for understanding end-user acceptance of an eHealth technology, early in the development process: The eHealth End-User Walkthrough.

METHODS

During a walkthrough, a participant is guided by using the technology via a scenario, a persona, and a low-fidelity protoype. A participant is questioned about factors that may affect acceptance during and after the demonstration. We show the value of the method via two case studies.

RESULTS

During the case studies, participants commented on whether they intend to use a technology and why they would (not) use its main features. They also provided redesign advice or input for additional functions. Finally, the sessions provide guidance for the generation of business models and implementation plans.

CONCLUSIONS

The eHealth End-User Walkthrough can aid design teams in understanding the acceptance of their eHealth application in a very early stage of the design process. Consequently, it can prevent a mismatch between technology and end-users’ needs, wishes and context.
Trends and Visibility of “Digital Health” as a Keyword in Articles by JMIR Publications in the New Millennium: Bibliographic-Bibliometric Analysis (Preprint)
Authors: Ahmadvand Alireza , Kavanagh David , Clark Michele , Drennan Judy , Nissen Lisa
Published: March 2018

BACKGROUND

Digital health has become an advancing phenomenon in the health care systems of modern societies. Over the past two decades, various digital health options, technologies, and innovations have been introduced; many of them are still being investigated and evaluated by researchers all around the globe. However, the actual trends and visibility of peer-reviewed publications using “digital health” as a keyword to reflect the topic, published by major relevant journals, still remain to be quantified.

OBJECTIVE

This study aimed to conduct a bibliographic-bibliometric analysis on articles published in JMIR Publications journals that used “digital health” as a keyword. We evaluated the trends, topics, and citations of these research publications to identify the important share and contribution of JMIR Publications journals in publishing articles on digital health.

METHODS

All JMIR Publications journals were searched to find articles in English, published between January 2000 and August 2019, in which the authors focused on, utilized, or discussed digital health in their study and used “digital health” as a keyword. In addition, a bibliographic-bibliometric analysis was conducted using the freely available Profiles Research Networking Software by the Harvard Clinical and Translational Science Center.

RESULTS

Out of 1797 articles having “digital health” as a keyword, published mostly between 2016 and 2019, 277 articles (32.3%) were published by JMIR Publications journals, mainly in the Journal of Medical Internet Research. The most frequently used keyword for the topic was “mHealth.” The average number of times an article had been cited, including self-citations, was above 2.8.

CONCLUSIONS

The reflection of “digital health” as a keyword in JMIR Publications journals has increased noticeably over the past few years. To maintain this momentum, more regular bibliographic and bibliometric analyses will be needed. This would encourage authors to consider publishing their articles in relevant, high-visibility journals and help these journals expand their supportive publication policies and become more inclusive of digital health.
Just-in-Time Feedback in Diet and Physical Activity Interventions: Systematic Review and Practical Design Framework (Preprint)
Authors: Schembre Susan M , Liao Yue , Robertson Michael C , Dunton Genevieve Fridlund , Kerr Jacqueline , Haffey Meghan E , Burnett Taylor , Basen-Engquist Karen , Hicklen Rachel S
Published: March 2018

BACKGROUND

The integration of body-worn sensors with mobile devices presents a tremendous opportunity to improve just-in-time behavioral interventions by enhancing bidirectional communication between investigators and their participants. This approach can be used to deliver supportive feedback at critical moments to optimize the attainment of health behavior goals.

OBJECTIVE

The goals of this systematic review were to summarize data on the content characteristics of feedback messaging used in diet and physical activity (PA) interventions and to develop a practical framework for designing just-in-time feedback for behavioral interventions.

METHODS

Interventions that included just-in-time feedback on PA, sedentary behavior, or dietary intake were eligible for inclusion. Feedback content and efficacy data were synthesized descriptively.

RESULTS

The review included 31 studies (15/31, 48%, targeting PA or sedentary behavior only; 13/31, 42%, targeting diet and PA; and 3/31, 10%, targeting diet only). All studies used just-in-time feedback, 30 (97%, 30/31) used personalized feedback, and 24 (78%, 24/31) used goal-oriented feedback, but only 5 (16%, 5/31) used actionable feedback. Of the 9 studies that tested the efficacy of providing feedback to promote behavior change, 4 reported significant improvements in health behavior. In 3 of these 4 studies, feedback was continuously available, goal-oriented, or actionable.

CONCLUSIONS

Feedback that was continuously available, personalized, and actionable relative to a known behavioral objective was prominent in intervention studies with significant behavior change outcomes. Future research should determine whether all or some of these characteristics are needed to optimize the effect of feedback in just-in-time interventions.
Web 2.0 Tools in the Prevention of Curable Sexually Transmitted Diseases: Scoping Review (Preprint)
Authors: Sanz-Lorente María , Wanden-Berghe Carmina , Castejón-Bolea Ramón , Sanz-Valero Javier
Published: March 2018

BACKGROUND

The internet is now the primary source of information that young people use to get information on issues related to sex, contraception, and sexually transmitted infections.

OBJECTIVE

The goal of the research was to review the scientific literature related to the use of Web 2.0 tools as opposed to other strategies in the prevention of curable sexually transmitted diseases (STDs).

METHODS

A scoping review was performed on the documentation indexed in the bibliographic databases MEDLINE, Cochrane Library, Scopus, Cumulative Index to Nursing and Allied Health Literature, Web of Science, Literatura Latinoamericana y del Caribe en Ciencias de la Salud, PsycINFO, Educational Resources Information Center, the databases of Centro Superior de Investigaciones Científicas in Spain, and the Índice Bibliográfico Español de Ciencias de la Salud from the first available date according to the characteristics of each database until April 2017. The equation search was realized by means of the using of descriptors together with the consultation of the fields of title register and summary with free terms. Bibliographies of the selected papers were searched for additional articles.

RESULTS

A total of 627 references were retrieved, of which 6 papers were selected after applying the inclusion and exclusion criteria. The STDs studied were chlamydia, gonorrhea, and syphilis. The Web 2.0 tools used were Facebook, Twitter, Instagram, and YouTube. The 6 papers used Web 2.0 in the promotion of STD detection.

CONCLUSIONS

Web 2.0 tools have demonstrated a positive effect on the promotion of prevention strategies for STDs and can help attract and link youth to campaigns related to sexual health. These tools can be combined with other interventions. In any case, Web 2.0 and especially Facebook have all the potential to become essential instruments for public health.
The Impact of Land Conversion on Income and Food Security Status For Farmer Households in 5 Villages in Temon Sub-District, Kulon Progo District, 2017
Authors: Nurpita Anisa , Wihastuti Latri , Andjani Ike Yuli
Published: March 2018

Preparation for the construction and development of  NYIA airport in Temon sub district, Kulon Progo district, D.I. Yogyakarta province has caused displacement of people for their land, including farmers. Farmers affected are located in five villages that include Jankaran, Palihan, Sindutan, Glagah and Kebon Rejo. The objective of this resrarch is to  analyze the impact of land conversion on farmer household incomes and food security status.  The research used both primary and secondary data. Primary data was collected using structured questionnaire.  Analysis of data was based on descriptive statistics and test of differences between paired samples. Results showed that land conversion has had a negative and significant influence on incomes of affected farmer households. The decline in household income of farmers in 5 villages in Temon sub district among other factors, is attributable to the reduction in farming land. Secondly, consequently, loss of farmer household income aggravated the vulnerability of the affected households to food insecurity.  The number of farmer households that experienced food insecurity increased from 87 percent of all farmer households prior to land conversion to 90 percent after land conversion. Conclusions formed the basis for several policy recommendations to mitigate and if possible overcome the problem.
Intramuscular Variations in Color and Sarcoplasmic Proteome of Beef Semimembranosus during Postmortem Aging
Authors: Nair Mahesh N. , Li Shuting , Beach Carol , Rentfrow Gregg , Suman Surendranath P.
Published: March 2018

Beef semimembranosus exhibits intramuscular difference in color stability, and the inside region (ISM) of the muscle is color-labile, whereas the outside region (OSM) is color-stable. Variations in sarcoplasmic proteins are known to contribute to this intramuscular color difference. Sarcoplasmic proteome and beef color are affected by postmortem aging. The objective of the present study was to examine the effect of aging on intramuscular color variations and the sarcoplasmic proteome of beef semimembranosus. Semimembranosus muscles obtained from 8 beef carcasses (n = 8) were subjected to aging at 2°C for 0, 7, 14, and 21 d. On each aging day, the muscles were fabricated into ISM and OSM steaks and allotted to refrigerated storage (2°C) under aerobic packaging. Instrumental color and metmyoglobin reducing activity were evaluated on d 0, 3, and 6 of storage. Samples frozen on d 0 and d 21 of aging were utilized for sarcoplasmic proteome analysis. Color attributes of both ISM and OSM steaks were influenced by aging, with steaks aged for 21 d having the lowest (P < 0.05) color stability. The ISM steaks had greater (P < 0.05) lightness than OSM counterparts, and the difference in lightness was not negated by aging. The ISM and OSM had similar (P > 0.05) redness on d 0 of storage, whereas ISM had lower (P < 0.05) redness compared to OSM on d 3 and d 6 of storage. Several proteins associated with glycolysis and energy metabolism were of greater abundance (P < 0.05) in OSM than in ISM after 21-d aging. Furthermore, the influence of 21-d aging on sarcoplasmic proteome was observed at a greater extent in OSM than in ISM, indicating that the effect of aging on sarcoplasmic proteome of beef semimembranosus was influenced by the location within the muscle.
AN INFORMATION SYSTEM SUCCESS MODEL FOR CLOUD COMPUTING IN INFORMATION TECHNOLOGY PROJECT
Authors: Zulfan Zulfan
Published: March 2018

Cloud computing is becoming an attractive technology due to its dynamic scalability and effective usage of the resources, it can be utilized under circumstances where the availability of resources is limited. The main aim of this study is to develop an IS successful model for cloud computing in IT project environment. There were 38 respondents participated in this study. Data were collected by surveys and analyzed by SPSS. The findings of the study revealed that the system under study was quite successful on use of cloud computing in IT project assignment and very useful. In addition to all hypotheses in this study were interrelated.
STUDI ANALISA INDEK KEPUASAN MAHASISWA PRODI PENDIDIKAN TEKNOLOGI INFORMASI UIN AR-RANIRY
Authors: Yusuf Bustami
Published: March 2018

The purpose of this study aims to analyze student satisfaction of Information Technology Education (ITE) Department, Faculty of Tarbiyah and Teacher Training, Ar-Raniry State Islamic University. The respondent are used all active students of ITE Department (N=460). This research uses quantitative, descriptive, and comparative method with Anova Test analysis based on lecturer, lecture, and year of class. The results of this study indicate that there are significant differences in student satisfaction either based on teaching lecturers (F=9,72, P>0.05), the courses taken (F = 6.639, p>0.05), or based on year of class(F=11.855, P>0.05). This research contributes as an initial evaluation material for department of ITE to improve the quality of student services.