bluuebunny/crossref_metadata_2025 huggingface dataset:
Space–time formation of very-large-scale motions in turbulent pipe flow
Authors: Lee Jae Hwa , Sung Hyung Jin , Adrian Ronald J.
Published: October 2019

We examine the origin of very-large-scale motions (VLSMs) in fully developed turbulent pipe flow at friction Reynolds number, $\mathit{Re}_{\unicode[STIX]{x1D70F}}=934$, using data from a direct numerical simulation. The VLSMs and the packet-like large-scale motions (LSMs) found in this study are very similar to those found in earlier studies. Three-dimensional time-evolving instantaneous fields show that one component of the process leading to the large streamwise length of VLSMs is the concatenation of adjacent streamwise LSMs caused by the continuous elongation of LSMs due to the strain component of the mean shear. Spatial organization patterns of the VLSMs and LSMs and their properties are studied by separating auto-correlation of the streamwise velocity fluctuations into the components of the VLSM and the LSM defined by low-pass/high-pass filtering in the streamwise direction. The structures of the two-point spatial correlations of the streamwise velocity component of the VLSMs and the LSMs in the streamwise-azimuthal plane are characterized by multiple maxima and complex patterns that beg explanation in terms of patterned coherent arrangements of the LSMs. Using proper orthogonal decomposition (POD), it is found that the X-shape correlation pattern of the VLSMs results from the superposition of very long helically inclined structures and streamwise-aligned structures. Further explanation of the patterns in the correlations of the VLSMs and LSMs is provided through the study of synthetically constructed arrangements of simple hairpin packet models of the LSM. Head-to-tail alignment of the model packets along streamwise and helical directions suggested by the eigenvalues of the POD creates a pair of long roll-cells centred above the logarithmic layer, and bracketing the LSMs. These roll-cells are pure kinematic consequences of the induction within the LSM packets, but they may also serve to organize smaller packets.
Increases in theta CSD power and coherence during a calibrated stop-signal task: implications for goal-conflict processing and the Behavioural Inhibition System
Authors: Lockhart Thomas S. , Moore Roger A. , Bard Kim A. , Stafford Lorenzo D.
Published: October 2019

Psychologists have identified multiple different forms of conflict, such as information processing conflict and goal conflict. As such, there is a need to examine the similarities and differences in neurology between each form of conflict. To address this, we conducted a comprehensive electroencephalogram (EEG) analysis of Shadli, Glue, McIntosh, and McNaughton’s calibrated stop-signal task (SST) goal-conflict task. Specifically, we examined changes in scalp-wide current source density (CSD) power and coherence across a wide range of frequency bands during the calibrated SST (n= 34). We assessed differences in EEG between the high and low goal-conflict conditions using hierarchical analyses of variance (ANOVAs). We also related goal-conflict EEG to trait anxiety, neuroticism, Behavioural Inhibition System (BIS)-anxiety and revised BIS (rBIS) using regression analyses. We found that changes in CSD power during goal conflict were limited to increased midfrontocentral theta. Conversely, coherence increased across 23 scalp-wide theta region pairs and one frontal delta region pair. Finally, scalp-wide theta significantly predicted trait neuroticism but not trait anxiety, BIS-anxiety or rBIS. We conclude that goal conflict involves increased midfrontocentral CSD theta power and scalp-wide theta-dominated coherence. Therefore, compared with information processing conflict, goal conflict displays a similar EEG power profile of midfrontocentral theta but a much wider coherence profile. Furthermore, the increases in theta during goal conflict are the characteristic of BIS-driven activity. Therefore, future research should confirm whether these goal-conflict effects are driven by the BIS by examining whether the effects are attenuated by anxiolytic drugs. Overall, we have identified a unique network of goal-conflict EEG during the calibrated SST.
First record of the Peruvian yellow-tailed woolly monkeyLagothrix flavicaudain the Región Junín, Peru
Authors: McHugh Sean M. , Cornejo Fanny M. , McKibben Jasmina , Zarate Melissa , Tello Carlos , Jiménez Carlos F. , Schmitt Christopher A.
Published: October 2019

The Critically Endangered Peruvian yellow-tailed woolly monkeyLagothrix flavicaudawas presumed to only occur in the tropical montane cloud forests between the Marañón and Huallaga rivers in northern Peru. Here we report the discovery of a population to the south of its previously known range, in the Región Junín. During September–December 2018 we carried out transect surveys to record large mammals present near the village of San Antonio in the district of Pampa Hermosa, at 1,287–2,015 m altitude. We recorded five primate species during transect surveys.Lagothrix flavicaudawas seen four times, and appeared phenotypically distinct from populations to the north, with notable white patches above each eye and a reduced yellow patch at the end of the tail. The presence ofL. flavicaudain Junín extends its known geographical range over 200 km southwards from the closest previously known population in the Huánuco region, and presents a unique opportunity for the conservation of this Critically Endangered species.
The Positioning of the Supreme Courts in Sweden – A Democratic Oddity?
Authors: Zamboni Mauro
Published: October 2019

The Swedish supreme courts as part of the public administration, rather than as independent actors – Political, legal, and administrative reasons behind this positioning – A recent trend shifts the position of the supreme courts – Endogenous forces (e.g. a more ‘conflictual’ political climate) and exogenous reasons (e.g. the increasing importance of the judicial-made EU law) – Swedish supreme courts nearer to being a body with the primary duty of safeguarding the law against the executive and legislative powers – ‘Full’ positioning of supreme courts within the judicial core not an essential institutional requirement for a democracy – Important role of the public administration’s degree of dependence on the legislative power
Satellite Discovery of Anomalously Large Methane Point Sources From Oil/Gas Production
Authors: Varon D. J. , McKeever J. , Jervis D. , Maasakkers J. D. , Pandey S. , Houweling S. , Aben I. , Scarpelli T. , Jacob D. J.
Published: October 2019

Rapid identification of anomalous methane sources in oil/gas fields could enable corrective action to fight climate change. The GHGSat‐D satellite instrument measuring atmospheric methane with 50‐meter spatial resolution was launched in 2016 to demonstrate space‐based monitoring of methane point sources. Here we report the GHGSat‐D discovery of an anomalously large, persistent methane source (10–43 metric tons per hour, detected in over 50% of observations) at a gas compressor station in Central Asia, together with additional sources (4–32 metric tons per hour) nearby. The TROPOMI satellite instrument confirms the magnitude of these large emissions going back to at least November 2017. We estimate that these sources released 142 ± 34 metric kilotons of methane to the atmosphere from February 2018 through January 2019, comparable to the 4‐month total emission from the well‐documented Aliso Canyon blowout.
MMS Measurements and Modeling of Peculiar Electromagnetic Ion Cyclotron Waves
Authors: Lee Justin H. , Turner Drew L. , Toledo‐Redondo Sergio , Vines Sarah K. , Allen Robert C. , Fuselier Stephen A. , Khotyaintsev Yuri V. , Cohen Ian J. , Mauk Barry H. , Russell Christopher T. , Pollock Craig J. , Ergun Robert E. , Lindqvist Per‐Arne L. , Burch James L.
Published: October 2019

Orbiting Earth's dayside outer magnetosphere on 29 September 2015, the Magnetospheric Multiscale (MMS) satellites measured plasma composition, simultaneous electromagnetic ion cyclotron waves, and intermittent fast plasma flows consistent with ultralow frequency waves or convection. Such flows can accelerate typically unobservable low‐energy plasma into a measurable energy range of spacecraft plasma instrumentation. We exploit the flow occurrence to ensure measurement of cold ion species alongside the hot particles—consisting of ionospheric heavy ions and solar wind He++—during a subinterval of wave emissions with spectral properties previously described as peculiar. Through application of the composition and multisatellite wave vector data to linear theory, we demonstrate the emissions are in fact consistent with theory, growing naturally in the He++ band with sufficient free energy.
A Priori Identification of Skillful Extratropical Subseasonal Forecasts
Authors: Albers John R. , Newman Matthew
Published: October 2019

The current generation of subseasonal operational model forecasts has, on average, low skill for leads beyond 3 weeks. This is likely a fundamental property of the climate system, due to the relative high amplitude of unpredictable weather variability compared to potentially predictable, but generally weaker, climate signals. Thus, for subseasonal forecasts to be useful, their high versus low skill events should be identified at time of forecast. We show that a linear inverse model (LIM), an empirical‐dynamical model constructed from covariability statistics of wintertime (December–March) weekly averaged observational analyses, can be used to identify, a priori, the expected extratropical subseasonal surface and midtropospheric forecast skill. The LIM's predicted signal‐to‐noise ratio identifies the subset (10%–30%) of Weeks 3–6 forecasts—of the LIM and two operational models from the National Centers for Environmental Prediction and the European Centre for Medium‐Range Weather Forecasts—with relatively higher skill versus the much larger remainder of forecasts whose skill cannot be distinguished from random chance.
Contemporaneous Observations of Jovian Energetic Auroral Electrons and Ultraviolet Emissions by the Juno Spacecraft
Authors: Gérard J.‐C. , Bonfond B. , Mauk B. H. , Gladstone G. R. , Yao Z. H. , Greathouse T. K. , Hue V. , Grodent D. , Gkouvelis L. , Kammer J. A. , Versteeg M. , Clark G. , Radioti A. , Connerney J. E. P. , Bolton S. J. , Levin S. M.
Published: October 2019

We present comparisons of precipitating electron flux and auroral brightness measurements made during several Juno transits over Jupiter's auroral regions in both hemispheres. We extract from the ultraviolet spectrograph (UVS) spectral imager H2 emission intensities at locations magnetically conjugate to the spacecraft using the JRM09 model. We use UVS images as close in time as possible to the electron measurements by the Jupiter Energetic Particle Detector Instrument (JEDI) instrument. The upward electron flux generally exceeds the downward component and shows a broadband energy distribution. Auroral intensity is related to total precipitated electron flux and compared with the energy‐integrated JEDI flux inside the loss cone. The far ultraviolet color ratio along the spacecraft footprint maps variations of the mean energy of the auroral electron precipitation. A wide diversity of situations has been observed. The intensity of the diffuse emission equatorward of the main oval is generally in fair agreement with the JEDI downward energy flux. The intensity of the ME matches exceeds or remains below the value expected from the JEDI electron energy flux. The polar emission may be more than an order of magnitude brighter than associated with the JEDI electron flux in association with high values of the color ratio. We tentatively explain these observations by the location of the electron energization region relative to Juno's orbit as it transits the auroral region. Current models predict that the extent and the altitude of electron acceleration along the magnetic field lines are consistent with this assumption.
Evaluation of FESOM2.0 Coupled to ECHAM6.3: Preindustrial and HighResMIP Simulations
Authors: Sidorenko D. , Goessling H.F. , Koldunov N.V. , Scholz P. , Danilov S. , Barbi D. , Cabos W. , Gurses O. , Harig S. , Hinrichs C. , Juricke S. , Lohmann G. , Losch M. , Mu L. , Rackow T. , Rakowsky N. , Sein D. , Semmler T. , Shi X. , Stepanek C. , Streffing J. , Wang Q. , Wekerle C. , Yang H. , Jung T.
Published: October 2019

A new global climate model setup using FESOM2.0 for the sea ice‐ocean component and ECHAM6.3 for the atmosphere and land surface has been developed. Replacing FESOM1.4 by FESOM2.0 promises a higher efficiency of the new climate setup compared to its predecessor. The new setup allows for long‐term climate integrations using a locally eddy‐resolving ocean. Here it is evaluated in terms of (1) the mean state and long‐term drift under preindustrial climate conditions, (2) the fidelity in simulating the historical warming, and (3) differences between coarse and eddy‐resolving ocean configurations. The results show that the realism of the new climate setup is overall within the range of existing models. In terms of oceanic temperatures, the historical warming signal is of smaller amplitude than the model drift in case of a relatively short spin‐up. However, it is argued that the strategy of “de‐drifting” climate runs after the short spin‐up, proposed by the HighResMIP protocol, allows one to isolate the warming signal. Moreover, the eddy‐permitting/resolving ocean setup shows notable improvements regarding the simulation of oceanic surface temperatures, in particular in the Southern Ocean.
Seasonal Hydropower Planning for Data‐Scarce Regions Using Multimodel Ensemble Forecasts, Remote Sensing Data, and Stochastic Programming
Authors: Koppa Akash , Gebremichael Mekonnen , Zambon Renato C. , Yeh William W.‐G. , Hopson Thomas M.
Published: October 2019

In data‐scarce regions, seasonal hydropower planning is hindered by the unavailability of reliable long‐term streamflow observations, which are required for the construction of inflow scenario trees. In this study, we develop a methodological framework to overcome the problem of streamflow data scarcity by combining precipitation forecasts from ensemble numerical weather prediction models, spatially distributed hydrologic models, and stochastic programming. We use evapotranspiration as a proxy for streamflow in generating reliable reservoir inflow forecasts. Using the framework, we compare three different formulations of inflow scenario structures and their applicability to data‐scarce regions: (1) a single deterministic forecast, (2) a scenario fan with the first stage deterministic, and (3) a scenario fan with all stages stochastic. We apply the framework to a cascade of two reservoirs in the Omo‐Gibe River basin in Ethiopia. Future reservoir inflows are generated using a 3‐model 30‐member ensemble seasonal precipitation forecast from the North American Multimodel Ensemble and the Noah‐MP hydrologic model. We then perform deterministic and stochastic optimization for hydropower operation and planning. Comparing the results from the three different inflow scenario structures, we observe that the uncertainty in reservoir inflows is significant only for the dry stages of the planning horizon. In addition, we find that the impact of model parameter uncertainty on hydropower production is significant (0.14–0.18×106 MWh).
Exploration of surgical blood pressure management and expected motor recovery in individuals with traumatic spinal cord injury
Authors: Ehsanian Reza , Haefeli Jenny , Quach Nhung , Kosarchuk Jacob , Torres Dolores , Stuck Ellen D. , Endo Jessica , Crew James D. , Dirlikov Benjamin , Bresnahan Jacqueline C. , Beattie Michael S. , Ferguson Adam R. , McKenna Stephen L.
Published: October 2019

Study design

Retrospective analysis.

Objective

To assess the impact of mean arterial blood pressure (MAP) during surgical intervention for spinal cord injury (SCI) on motor recovery.

Setting

Level-one Trauma Hospital and Acute Rehabilitation Hospital in San Jose, CA, USA.

Methods

Twenty-five individuals with traumatic SCI who received surgical and acute rehabilitation care at a level-one trauma center were included in this study. The Surgical Information System captured intraoperative MAPs on a minute-by-minute basis and exposure was quantified at sequential thresholds from 50 to 104 mmHg. Change in International Standards for Neurological Classification of Spinal Cord Injury (ISNCSCI) motor score was calculated based on physiatry evaluations at the earliest postoperative time and at discharge from acute rehabilitation. Linear regression models were used to estimate the rate of recovery across the entire MAP range.

Results

An exploratory analysis revealed that increased time within an intraoperative MAP range (70–94 mmHg) was associated with ISNCSCI motor score improvement. A significant regression equation was found for the MAP range 70–94 mmHg (F[1, 23] = 4.65, r2 = 0.168, p = 0.042). ISNCSCI motor scores increased 0.036 for each minute of exposure to the MAP range 70–94 mmHg during the operative procedure; this represents a significant correlation between intraoperative time with MAP 70–94 and subsequent motor recovery. Blood pressure exposures above or below this range did not display a positive association with motor recovery.

Conclusions

Hypertension as well as hypotension during surgery may impact the trajectory of recovery in individuals with SCI, and there may be a direct relationship between intraoperative MAP and motor recovery.
Oral health knowledge, attitude and behaviour of dental students in a private university
Authors: Al-wesabi Azhar Abdulrahman , Abdelgawad Fatma , Sasahara Hisako , El Motayam Kamal
Published: October 2019

Introduction

The positive attitude and behaviour of dental students can be improved during their undergraduate studies and is considered an essential factor in promoting the oral self-care habits of their patients and society in general.

Aim

This study was conducted to evaluate the oral health knowledge, attitudes and behaviours among undergraduate dental students at a private university, based on the year of undergraduate studies.

Material and methods

A self-administered questionnaire based on the Hiroshima University-Dental Behavioural Inventory was distributed among 783 undergraduate dental students from 1st to 5th year. Statistical analysis was performed using SPSS version 20. The Mann–Whitney U test and one-way ANOVA tests (Kruskal–Wallis test) were used.

Results

The scores of oral health knowledge, attitude and behaviour between preclinical and clinical dental students were found to have statistically significant differences (P < 0.001). The variation of knowledge, attitude and behaviour scores from 1st to 5th year undergraduate studies was shown to be statistically significant with the year of study (P < 0.001). The study showed significant improvement in the knowledge, attitude and behaviour of the final year dental students as compared with the 1st year dental students.

Conclusion

Preclinical students need properly designed oral health educational programs to increase their attitude and behaviour toward oral health.
Exploring specific prognostic biomarkers in triple-negative breast cancer
Authors: Bao Chang , Lu Yunkun , Chen Jishun , Chen Danni , Lou Weiyang , Ding Bisha , Xu Liang , Fan Weimin
Published: October 2019

Lacking of both prognostic biomarkers and therapeutic targets, triple-negative breast cancer (TNBC) underscores pivotal needs to uncover novel biomarkers and viable therapies. MicroRNAs have broad biological functions in cancers and may serve as ideal biomarkers. In this study, by data mining of the Cancer Genome Atlas database, we screened out 4 differentially-expressed microRNAs (DEmiRNAs) between TNBC and normal samples: miR-135b-5p, miR-9-3p, miR-135b-3p and miR-455-5p. They were specially correlated with the prognosis of TNBC but not non-TNBC. The weighted correlation network analysis (WGCNA) for potential target genes of 3 good prognosis-related DEmiRNAs (miR-135b-5p, miR-9-3p, miR-135b-3p) identified 4 hub genes with highly positive correlation with TNBC subtype: FOXC1, BCL11A, FAM171A1 and RGMA. The targeting relationships between miR-9-3p and FOXC1/FAM171A1, miR-135b-3p and RGMA were validated by dual-luciferase reporter assays. Importantly, the regulatory functions of 4 DEmiRNAs and 3 verified target genes on cell proliferation and migration were explored in TNBC cell lines. In conclusion, we shed lights on these 4 DEmiRNAs (miR-135b-5p, miR-9-3p, miR-135b-3p, miR-455-5p) and 3 hub genes (FOXC1, FAM171A1, RGMA) as specific prognostic biomarkers and promising therapeutic targets for TNBC.
Macrophages reprogrammed by lung cancer microparticles promote tumor development via release of IL-1β
Authors: Chen Jie , Sun Weiwei , Zhang Huafeng , Ma Jingwei , Xu Pingwei , Yu Yuandong , Fang Haiqing , Zhou Li , Lv Jiadi , Xie Jing , Liu Yuying , Tang Ke , Huang Bo
Published: October 2019

Despite their mutual antagonism, inflammation and immunosuppression coexist in tumor microenvironments due to tumor and immune cell interactions, but the underlying mechanism remains unclear. Previously, we showed that tumor cell-derived microparticles induce an M2 phenotype characterized by immunosuppression in tumor-infiltrating macrophages. Here, we further showed that lung cancer microparticles (L-MPs) induce macrophages to release a key proinflammatory cytokine, IL-1β, thus promoting lung cancer development. The underlying mechanism involves the activation of TLR3 and the NLRP3 inflammasome by L-MPs. More importantly, tyrosine kinase inhibitor treatment-induced L-MPs also induce human macrophages to release IL-1β, leading to a tumor-promoting effect in a humanized mouse model. These findings demonstrated that in addition to their anti-inflammatory effect, L-MPs induce a proinflammatory phenotype in tumor-infiltrating macrophages, promoting the development of inflammatory and immunosuppressive tumor microenvironments.
Author Correction: Extracellular vesicles protect glucuronidase model enzymes during freeze-drying
Authors: Frank Julia , Richter Maximilian , de Rossi Chiara , Lehr Claus-Michael , Fuhrmann Kathrin , Fuhrmann Gregor
Published: October 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Generation of concentric perfect Poincaré beams
Authors: Gu Zhongzheng , Yin Da , Gu Fengyan , Zhang Yanran , Nie Shouping , Feng Shaotong , Ma Jun , Yuan Caojin
Published: October 2019

We theoretically propose and experimentally verify a method to generate new polycyclic beams, namely concentric perfect Poincaré beams (CPPBs), by using an encoded annular phase mask. The proposed beams consisting of multiple polarization structured fields can be simultaneously generated in one concentric mode, which are respectively mapped by fundamental Poincaré sphere (PS), high-order Poincaré sphere (HOPS), and hybrid-order Poincaré sphere (HyPS). Moreover, the ring radius, numbers and polarization orders of the CPPBs at arbitrary positions on arbitrary PS are independently controlled. This work enriches the mode distributions of perfect vortex and introduces a new polarization degree of freedom, which has the potential to implement more information beyond the orbital angular momentum multiplexing in optical communication.
Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability to Metabolic Homeostasis and Disease states
Authors: Somvanshi Pramod R. , Tomar Manu , Kareenhalli Venkatesh
Published: October 2019

Insulin and glucagon control plasma macronutrient homeostasis through their signalling network composed of multiple feedback and crosstalk interactions. To understand how these interactions contribute to metabolic homeostasis and disease states, we analysed the steady state response of metabolic regulation (catabolic or anabolic) with respect to structural and input perturbations in the integrated signalling network, for varying levels of plasma glucose. Structural perturbations revealed: the positive feedback of AKT on IRS is responsible for the bistability in anabolic zone (glucose >5.5 mmol); the positive feedback of calcium on cAMP is responsible for ensuring ultrasensitive response in catabolic zone (glucose <4.5 mmol); the crosstalk between AKT and PDE3 is responsible for efficient catabolic response under low glucose condition; the crosstalk between DAG and PKC regulates the span of anabolic bistable region with respect to plasma glucose levels. The macronutrient perturbations revealed: varying plasma amino acids and fatty acids from normal to high levels gradually shifted the bistable response towards higher glucose range, eventually making the response catabolic or unresponsive to increasing glucose levels. The analysis reveals that certain macronutrient composition may be more conducive to homeostasis than others. The network perturbations that may contribute to disease states such as diabetes, obesity and cancer are discussed.
Enhanced glacial discharge from the eastern Antarctic Peninsula since the 1700s associated with a positive Southern Annular Mode
Authors: Dickens W. A. , Kuhn G. , Leng M. J. , Graham A. G. C. , Dowdeswell J. A. , Meredith M. P. , Hillenbrand C.-D. , Hodgson D. A. , Roberts S. J. , Sloane H. , Smith J. A.
Published: October 2019

The Antarctic Peninsula Ice Sheet is currently experiencing sustained and accelerating loss of ice. Determining when these changes were initiated and identifying the main drivers is hampered by the short instrumental record (1992 to present). Here we present a 6,250 year record of glacial discharge based on the oxygen isotope composition of diatoms (δ18Odiatom) from a marine core located at the north-eastern tip of the Antarctic Peninsula. We find that glacial discharge - sourced primarily from ice shelf and iceberg melting along the eastern Antarctic Peninsula – remained largely stable between ~6,250 to 1,620 cal. yr BP, with a slight increase in variability until ~720 cal. yr. BP. An increasing trend in glacial discharge occurs after 550 cal. yr BP (A.D. 1400), reaching levels unprecedented during the past 6,250 years after 244 cal. yr BP (A.D. 1706). A marked acceleration in the rate of glacial discharge is also observed in the early part of twentieth century (after A.D. 1912). Enhanced glacial discharge, particularly after the 1700s is linked to a positive Southern Annular Mode (SAM). We argue that a positive SAM drove stronger westerly winds, atmospheric warming and surface ablation on the eastern Antarctic Peninsula whilst simultaneously entraining more warm water into the Weddell Gyre, potentially increasing melting on the undersides of ice shelves. A possible implication of our data is that ice shelves in this region have been thinning for at least ~300 years, potentially predisposing them to collapse under intensified anthropogenic warming.
Geochemical Evidence for the Control of Fire by Middle Palaeolithic Hominins
Authors: Brittingham Alex , Hren Michael T. , Hartman Gideon , Wilkinson Keith N. , Mallol Carolina , Gasparyan Boris , Adler Daniel S.
Published: October 2019

The use of fire played an important role in the social and technological development of the genus Homo. Most archaeologists agree that this was a multi-stage process, beginning with the exploitation of natural fires and ending with the ability to create fire from scratch. Some have argued that in the Middle Palaeolithic (MP) hominin fire use was limited by the availability of fire in the landscape. Here, we present a record of the abundance of polycyclic aromatic hydrocarbons (PAHs), organic compounds that are produced during the combustion of organic material, from Lusakert Cave, a MP site in Armenia. We find no correlation between the abundance of light PAHs (3–4 rings), which are a major component of wildfire PAH emissions and are shown to disperse widely during fire events, and heavy PAHs (5–6 rings), which are a major component of particulate emissions of burned wood. Instead, we find heavy PAHs correlate with MP artifact density at the site. Given that hPAH abundance correlates with occupation intensity rather than lPAH abundance, we argue that MP hominins were able to control fire and utilize it regardless of the variability of fires in the environment. Together with other studies on MP fire use, these results suggest that the ability of hominins to manipulate fire independent of exploitation of wildfires was spatially variable in the MP and may have developed multiple times in the genus Homo.
The burden and correlates of multiple cardiometabolic risk factors in a semi-urban population of Nepal: a community-based cross-sectional study
Authors: Gyawali Bishal , Mishra Shiva Raj , Ghimire Saruna , Hansen Martin Rune Hassan , Shah Kishor Jung , Subedee Koshal Chandra , Soti Pabitra Babu , Neupane Dinesh , Kallestrup Per
Published: October 2019

This study assessed the burden and correlates of three cardiometabolic risk factors, (hypertension, diabetes, and overweight/obesity), and their possible clustering patterns in a semi-urban population of Nepal. Data were obtained from a community-based management of non-communicable disease in Nepal (COBIN) Wave II study, which included 2,310 adults aged 25–64 years in a semi-urban area of Pokhara Metropolitan City of Nepal, using the World Health Organization-STEPS questionnaire. Unadjusted and adjusted binary logistic regression models were used to study the correlates of the individual risk factors and their clustering. The prevalence of hypertension, diabetes, and overweight/obesity was 34.5%, 11.7%, and 52.9%, respectively. In total, 68.2% of the participants had at least one risk factor and many participants had two risks in combination: 6.8% for ‘hypertension and diabetes’, 7.4% for ‘diabetes and overweight/obesity’ and 21.4% for ‘hypertension and overweight/obesity’. In total, 4.7% had all three risk factors. Janajati ethnicity (1.4–2.1 times), male gender (1.5 times) and family history of diabetes (1.4–3.4 times) were associated with presence of individual risk factors. Similarly, Janajati ethnicity (aOR: 4.31, 95% CI: 2.53–7.32), current smoking (aOR: 4.81, 95% CI: 2.27–10.21), and family history of diabetes (aOR: 4.60, 95% CI: 2.67–7.91) were associated with presence of all three risk factors. Our study found a high prevalence of all single and combined cardiometabolic risk factors in Nepal. It underlines the need to manage risk factors in aggregate and plan prevention activities targeting multiple risk factors.
Repeatability and comparison of new Corvis ST parameters in normal and keratoconus eyes
Authors: Yang Kaili , Xu Liyan , Fan Qi , Zhao* Dongqing , Ren* Shengwei
Published: October 2019

To evaluate the repeatability of corneal biomechanical parameters in normal and keratoconus eyes, and explore factors that affects the repeatability, and further assess the diagnostic ability of new parameters. Seventy-seven keratoconus eyes of 47 patients and 77 right eyes of 77 normal subjects were recruited in current study. All participants received three repeated measurements with 2 to 5 minutes interval. The interclass correlation coefficient (ICC), Cronbach’ α and repeatability coefficient (RC) were evaluated. The liner regression analysis was used to identify factors that affect the repeatability, and linear mixed effects model was performed to compare the parameters differences. The receiver operating characteristic (ROC) curve was used to evaluate the diagnostic ability of new parameters. Eighteen parameters in normal eyes and twenty-two parameters in keratoconus eyes showed excellent repeatability (ICC ≥ 0.90). Age, axial measurement (AL), spherical equivalent, astigmatism, gender, mean keratometry (Kmean), intraocular pressure (IOP) and central corneal thickness (CCT) could affect the repeatability of new Corvis ST parameters. Compared with normal eyes, the Ambrósio’s Relational Thickness horizontal (ARTh), biomechanical corrected IOP (bIOP), stiffness parameter at first applanation (SP A1) were low and the Max Inverse Radius, deformation amplitude (DA) Ratio Max [2 mm], Pachy Slope, DA Ratio Max [1 mm], Integrated Radius and Corvis Biomechanical Index (CBI) were high in keratoconus eyes (All P < 0.05). Both ARTh and CBI had high Youden index (0.870), and the corresponding cut-off values were 379.29 and 0.44. The repeatability of Corvis ST parameters was acceptable both in normal and keratoconus eyes, and new parameters could effectively diagnose keratoconus eyes from normal eyes.
Computational Studies on the Thermodynamic and Kinetic Parameters of Oxidation of 2-Methoxyethanol Biofuel via H-Atom Abstraction by Methyl Radical
Authors: Abdel-Rahman Mohamed A. , El-Gogary Tarek M. , Al-Hashimi Nessreen , Shibl Mohamed F. , Yoshizawa Kazunari , El-Nahas Ahmed M.
Published: October 2019

In this work, a theoretical investigation of thermochemistry and kinetics of the oxidation of bifunctional 2-Methoxyethanol (2ME) biofuel using methyl radical was introduced. Potential-energy surface for various channels for the oxidation of 2ME was studied at density function theory (M06-2X) andab initioCBS-QB3 levels of theory. H-atom abstraction reactions, which are essential processes occurring in the initial stages of the combustion or oxidation of organic compounds, from different sites of 2ME were examined. A similar study was conducted for the isoelectronicn-butanol to highlight the consequences of replacing the ϒ CH2group by an oxygen atom on the thermodynamic and kinetic parameters of the oxidation processes. Rate coefficients were calculated from the transition state theory. Our calculations show that energy barriers forn-butanol oxidation increase in the order of α ‹ O ‹ ϒ ‹ β ‹ ξ, which are consistent with previous data. However, for 2ME the energy barriers increase in the order α ‹ β ‹ ξ ‹ O. At elevated temperatures, a slightly high total abstraction rate is observed for the bifunctional 2ME (4 abstraction positions) overn-butanol (5 abstraction positions).
Radiomics features on radiotherapy treatment planning CT can predict patient survival in locally advanced rectal cancer patients
Authors: Wang Jiazhou , Shen Lijun , Zhong Haoyu , Zhou Zhen , Hu Panpan , Gan Jiayu , Luo Ruiyan , Hu Weigang , Zhang Zhen
Published: October 2019

This retrospective study was to investigate whether radiomics feature come from radiotherapy treatment planning CT can predict prognosis in locally advanced rectal cancer patients treated with neoadjuvant chemoradiation followed by surgery. Four-hundred-eleven locally advanced rectal cancer patients which were treated with neoadjuvant chemoradiation enrolled in this study. All patients’ radiotherapy treatment planning CTs were collected. Tumor was delineated on these CTs by physicians. An in-house radiomics software was used to calculate 271 radiomics features. The results of test-retest and contour-recontour studies were used to filter stable radiomics (Spearman correlation coefficient > 0.7). Twenty-one radiomics features were final enrolled. The performance of prediction model with the radiomics or clinical features were calculated. The clinical outcomes include local control, distant control, disease-free survival (DFS) and overall survival (OS). Model performance C-index was evaluated by C-index. Patients are divided into two groups by cluster results. The results of chi-square test revealed that the radiomics feature cluster is independent of clinical features. Patients have significant differences in OS (p = 0.032, log rank test) for these two groups. By supervised modeling, radiomics features can improve the prediction power of OS from 0.672 [0.617 0.728] with clinical features only to 0.730 [0.658 0.801]. In conclusion, the radiomics features from radiotherapy CT can potentially predict OS for locally advanced rectal cancer patients with neoadjuvant chemoradiation treatment.
The Evolutionary Radiation of Hominids: a Phylogenetic Comparative Study
Authors: Rocatti Guido , Perez S. Ivan
Published: October 2019

Over the last 150 years the diversity and phylogenetic relationships of the hominoids have been one of the main focuses in biological and anthropological research. Despite this, the study of factors involved in their evolutionary radiation and the origin of the hominin clade, a key subject for the further understanding of human evolution, remained mostly unexplored. Here we quantitatively approach these events using phylogenetic comparative methods and craniofacial morphometric data from extant and fossil hominoid species. Specifically, we explore alternative evolutionary models that allow us to gain new insights into this clade diversification process. Our results show a complex and variable scenario involving different evolutionary regimes through the hominid evolutionary radiation –modeled by Ornstein-Uhlenbeck multi-selective regime and Brownian motion multi-rate scenarios–. These different evolutionary regimes might relate to distinct ecological and cultural factors previously suggested to explain hominid evolution at different evolutionary scales along the last 10 million years.
A novel metric reveals biotic resistance potential and informs predictions of invasion success
Authors: Cuthbert Ross N. , Callaghan Amanda , Dick Jaimie T. A.
Published: October 2019

Invasive species continue to proliferate and detrimentally impact ecosystems on a global scale. Whilst impacts are well-documented for many invaders, we lack tools to predict biotic resistance and invasion success. Biotic resistance from communities may be a particularly important determinant of the success of invaders. The present study develops traditional ecological concepts to better understand and quantify biotic resistance. We quantified predation towards the highly invasive Asian tiger mosquitoAedes albopictusand a representative native mosquitoCulex pipiensby three native and widespread cyclopoid copepods, using functional response and prey switching experiments. All copepods demonstrated higher magnitude type II functional responses towards the invasive prey over the analogous native prey, aligned with higher attack and maximum feeding rates. All predators exhibited significant, frequency-independent prey preferences for the invader. With these results, we developed a novel metric for biotic resistance which integrates predator numerical response proxies, revealing differential biotic resistance potential among predators. Our results are consistent with field patterns of biotic resistance and invasion success, illustrating the predictive capacity of our methods. We thus propose the further development of traditional ecological concepts, such as functional responses, numerical responses and prey switching, in the evaluation of biotic resistance and invasion success.
Illumina-based Analysis of Endophytic Bacterial Diversity of four Allium species
Authors: Huang Yonghong
Published: October 2019

Allium species are popular vegetables in China and possess antifungal and antibacterial activities. This study aimed to compare the endophytic bacterial community in the four crucial Allium species in China, Chinese leek (CL), garlic (GA), onion (ON,) and Welsh onion (WO), using sequences of the V3–V4 region of the bacterial 16S rRNA gene. A total of 1,036,637 high-quality sequences and 719 operational taxonomic units (OTUs) were obtained across all libraries. A total of 20 phyla, 50 classes, 80 orders, 134 families, and 234 genera were identified. Among them, 18 OTUs and 19 genera were shared among the four Allium species. Proteobacteria (42.68%) and Bacteroidetes (20.18%) were the dominant phyla in CL, while one unclassified (>70%) was the dominant phyla in the other three Allium species. The alpha-diversity analysis showed the bacterial richness and diversity in CL were significantly higher than those in the other three Allium species. Principal coordinate analysis (PCA) showed endophytic bacterial communities in GA, WO, and ON were more similar than those in CL. Phylogenetic Investigation of Communities by Reconstruction of Unobserved States (PICRUSt) analysis revealed endophytic bacteria mostly enriched in Membrane Transport, Amino Acid Metabolism and Carbohydrate Metabolism pathway. 17 of the 23 Kyoto Encyclopedia of Genes and Genomes (KEGG) categories and 159 of the 206 lower-level KEGG pathways in CL were significantly higher than those in the other three Allium species. Pearson’s correlation indicated that KEGG pathways with significant differences among the Allium species were closely related to the bacterial genera with significant differences between the Allium species. The findings of our study provided insight into the complex endophytic microbial communities in Allium species.
Effects of intramuscular and vaginal progesterone supplementation on frozen-thawed embryo transfer
Authors: Jiang Lei , Luo Zhuo-Ye , Hao Gui-Min , Gao Bu-Lang
Published: October 2019

This study was to investigate effects of progesterone vaginal sustained-release gel and intramuscular injection of progesterone on frozen-thawed embryos transfer in 3013 patients receiving vaginal progesterone sustained-release gel and progesterone injection in artificial cycle for frozen-thawed embryo transfer. All patients were divided into two groups: group A with progesterone intramuscular injection (60 mg/d) plus dydrogesterone (10 mg tid) and group B with progesterone vaginal sustained-release gel of progesterone (90 mg/d) plus dydrogesterone (10 mg tid). There were 1988 women in group A treated with progesterone injection and 1025 women in group B with progesterone vaginal sustained-release gel. There were no statistically (P > 0.05) significant difference between the two groups in age, years of infertility, body mass index, endometrial thickness at transfer time, the average numbers of embryo transferred, cause of infertility, number of cycles, pregnancy rate and ectopic pregnancy rate. No significant (P > 0.05) differences existed in the clinical pregnancy (52.5% vs. 56.0%) and ectopic pregnancy (2.2% vs. 3.0%) rate between groups A and B. However, group B with vaginal progesterone supplementation had significantly (P < 0.05) greater implantation (37.0% vs 34.4%), delivery (45.1% vs. 41.0%) and live birth (45.0% vs. 40.8%) rate than group A with intramuscular progesterone injection, whereas group A had significantly (P < 0.05) greater early abortion rate (19.4% vs. 15.3%) than group B. This study showed that vaginal gel progesterone supplementation has good effects on frozen-thawed embryo transfer and can significantly increase the rate of implantation, delivery and live birth but decrease the abortion rate compared with intramuscular progesterone injection.
Seasonality of climatic drivers of flood variability in the conterminous United States
Authors: Dickinson Jesse E. , Harden Tessa M. , McCabe Gregory J.
Published: October 2019

Flood variability due to changes in climate is a major economic and social concern. Climate drivers can affect the amount and distribution of flood-generating precipitation through seasonal shifts in storm tracks. An understanding of how the drivers may change in the future is critical for identifying the regions where the magnitude of floods may change. Here we show the regions in the conterminous U.S. where seasonal changes in global-scale climate oscillations have driven a large part of the variability of flood magnitude. The regions are cohesive across multiple watershed boundaries suggesting that variability in floods is driven by regional climate influences. Correlations with climate indices indicate that floods in the western and southern U.S. are most affected by global-scale climate. The regions provide a useful approach for characterizing flood variability and for attributing climatic drivers on flood variability and magnitude.
Protection from noise-induced cochlear synaptopathy by virally mediated overexpression of NT3
Authors: Hashimoto Ken , Hickman Tyler T. , Suzuki Jun , Ji Lingchao , Kohrman David C. , Corfas Gabriel , Liberman M. Charles
Published: October 2019

Noise exposures causing only transient threshold shifts can destroy auditory-nerve synapses without damaging hair cells. Here, we asked whether virally mediated neurotrophin3 (NT3) overexpression can repair this damage. CBA/CaJ mice at 6 wks were injected unilaterally with adeno-associated virus (AAV) containing either NT3 or GFP genes, via the posterior semicircular canal, 3 wks prior to, or 5 hrs after, noise exposure. Controls included exposed animals receiving vehicle only, and unexposed animals receiving virus. Thresholds were measured 2 wks post-exposure, just before cochleas were harvested for histological analysis. In separate virus-injected animals, unexposed cochleas were extracted for qRT-PCR. The GFP reporter showed that inner hair cells (IHCs) were transfected throughout the cochlea, and outer hair cells mainly in the apex. qRT-PCR showed 4- to 10-fold overexpression of NT3 from 1–21 days post-injection, and 1.7-fold overexpression at 40 days. AAV-NT3 delivered prior to noise exposure produced a dose-dependent reduction of synaptopathy, with nearly complete rescue at some cochlear locations. In unexposed ears, NT3 overexpression did not affect thresholds, however GFP overexpression caused IHC loss. In exposed ears, NT3 overexpression increased permanent threshold shifts. Thus, although NT3 overexpression can minimize noise-induced synaptic damage, the forced overexpression may be harmful to hair cells themselves during cochlear overstimulation.
Effect of natural ageing and heat treatments on GII.4 norovirus binding to Histo-Blood Group Antigens
Authors: Robin Maëlle , Chassaing Manon , Loutreul Julie , de Rougemont Alexis , Belliot Gaël , Majou Didier , Gantzer Christophe , Boudaud Nicolas
Published: October 2019

Human noroviruses (HuNoVs) are the leading cause of viral foodborne outbreaks worldwide. To date, no available methods can be routinely used to detect infectious HuNoVs in foodstuffs. HuNoVs recognize Histo-Blood Group Antigens (HBGAs) through the binding pocket (BP) of capsid protein VP1, which promotes infection in the host cell. In this context, the suitability of human HBGA-binding assays to evaluate the BP integrity of HuNoVs was studied on GII.4 virus-like particles (VLPs) and GII.4 HuNoVs during natural ageing at 20 °C and heat treatments. Our results demonstrate that this approach may reduce the over-estimation of potential infectious HuNoVs resulting from solely using the genome detection, even though some limitations have been identified. The specificity of HBGA-binding to the BP is clearly dependent on the HGBA type (as previously evidenced) and the ionic strength of the media without disturbing such interactions. This study also provides new arguments regarding the ability of VLPs to mimic HuNoV behavior during inactivation treatments. The BP stability of VLPs was at least 4.3 fold lower than that of HuNoVs at 20 °C, whereas capsids of both particles were disrupted at 72 °C. Thus, VLPs are relevant surrogates of HuNoVs for inactivation treatments inducing significant changes in the capsid structure.