bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinetics of Ca2+ Dissociation from Cod Parvalbumin Studied by
Fluorescent Stopped-flow Method
Authors: Vologzhannikova Alisa A. , Emelyanenko Victor I. , Kazakov Alexey S. , Borisova Nadezhda I. , Permyakov Eugene A.
Published: January 2023

Background:

Small Ca2+-binding protein parvalbumin possesses two strong Ca2+/Mg2+-
binding sites located within two EF-hand domains. Most parvalbumins have no tryptophan residues,
while cod protein contains a single tryptophan residue, which fluorescence (spectrum maximum
position and fluorescence quantum yield) is highly sensitive to the Ca2+ association/dissociation.

Objective:

Intrinsic protein fluorescence of cod parvalbumin can be used for elucidating the
mechanism of Ca2+ binding to this protein. Fluorescence of the single tryptophan residue of cod
parvalbumin has been used to monitor Ca2+-induced changes in the protein, both in steady-state and
kinetic mode.

Methods:

Steady-state fluorescence spectra of cod parvalbumin were measured using Cary Eclipse
spectrofluorimeter. Stopped-flow accessories in combination with a novel high-speed spectrofluorimeter
were used for measurements of kinetics of Ca2+ dissociation from cod parvalbumin after
fast mixing of Ca2+-loaded protein with a chelator of divalent metal cations ethylenediaminetetraacetic
acid (EDTA).

Results:

The fluorescent phase plots (fluorescence intensity at a fixed wavelength plotted against a
fluorescence intensity at another fixed wavelength), constructed from steady state and kinetical data,
shows a break at [Ca2+]/[parvalbumin] ratio close to 1. This means that the transition passes through an
intermediate state, which is a protein with one bound calcium ion. These observations indicate that the
binding of Ca2+ to cod parvalbumin is sequential.

Conclusion:

The results of the present spectral study showed that the binding of Ca2+ to cod
parvalbumin is a sequential process. Calcium dissociation rate constants for the two binding sites of
cod parvalbumin evaluated from the kinetic data are koff1 = 1.0 s-1 and koff2 = 1.5 s-1.
A New Class of Diacidic Nonpeptide Angiotensin II Receptor Antagonists: Candesartan Cilexetil
Authors: Naka Takehiko , Kubo Keiji
Published: January 2023

Blockade of the action of angiotensin II (AII) has long been a target for development of novel antihypertensive agents. We recently discovered a novel class of potent nonpeptide AII receptor antagonists, benzimidazole-7-carboxylic acids including candesartan. Candesartan is a highly potent and insurmountable angiotensin II type- I receptor (AT1)-selective antagonist. Structure-activity relation­
ship (SAR) studies revealed that the adjacent arrangement of a lipophilic substituent, a
tetrazolylbiphenylmethyl moiety and a carboxyl group was the important structural requirement for potent AIi antagonistic activity. The benzimidazole ring was found to be one of the most suitable templates arranging these three essential components in correct direction. Especially, the presence of a carboxyl group at the 7-position was found to be essential for insurmountable antagonism. Although candesartan is a very potent AIi antagonist, it was found to be absorbed rather inefficiently upon oral administration. To improve bioavailability (BA) of candesartan, chemical modification was examined to yield candesartan cilexetil, a prodrug of candesartan. Candesartan cilexetil is a potent and long-acting blocker that provides effective 24 hr blood pressure control. Our alternative research efforts to improve oral BA was performed by replacement of the tetrazole ring in candesartan by other new acidic bioisosteric heterocyclic rings to find the nonprodrug AII antagonist TAK-536, bearing 5-oxo-1,2,4-oxadiazole ring, which was as potent and orally active as candesartan cilexetil
15-Lipoxygenase and Its Inhibition: A Novel Therapeutic Target for Vascular Disease
Authors: Cornicelli J. A. , Trivedi B. K.
Published: January 2023

The disease process known as atherosclerosis is the leading cause of morbidity and mortality in the Western world. Current therapies have focused on treating the major risk factors identified to date including plasma lipid derangements, hypertension, clotting disorders, and diabetes. However, a significant number of individuals will be diagnosed with this malady in the apparent absence of known risk factors. Recent attention has turned toward treating the disease at the level of the vessel wall. In this review, we assess the relevancy of the oxygenating enzyme I 5-lipoxygenase (15-LO) as a therapeutic target. In vitro studies suggest that this enzyme may be involved in processes that modify native LDL in such a way as to be avidly taken up by tissue macrophages. In support of this contention are reports demonstrating the colocalization of 15-LO with macrophage-rich arterial lesions and epitopes of modified LDL. Investigations using transgenic animals also suggest that the site of 15-LO expression may be an important factor in the development of the disease. The alteration of important cellular fatty acids may also generate intracellular signals that promote a pro-atherogenic phenotype in the absence of measurable changes in bulk lipid peroxidation. A limited number of studies have exa,mined 15-LO inhibitors and those structural determinants necessary for inhibition of the enzyme. These include natural products and synthetic analogs. Structure activity relationships have been defined for a number of compounds including caffeic acid derivatives, propargyl ethers, and catechols. A novel, potent, specific inhibitor of IS-LO that lacks significant antioxidant activity was tested for its ability to inhibit atherosclerotic lesion formation in vivo. This benzothiopyranoindole virtually eliminated lesion formation in two animal models in the absence of significant changes in plasma lipids. Further, it prevented the progression of pre­ established lesions in another study. Collectively, these data provide a strong scientific rationale for exploring the inhibition of 15-LO as a therapeutic strategy.
Design and Preparation of Cyclopept mine Antifungal Agents
Authors: Klein L. L. , Li L.
Published: January 2023

The lack of agents for infections caused by pathogenic fungi has demanded further investigation of a key lead structure which has shown promise, echinocandin B. In recent years, two analogs of this cyclic hexapeptide are proceeding through the clinic exhibiting proof of concept for the target of these drugs. This target, the P-1,3-glucan synthesis complex, produces the majority of fungal cell wall glucan in many of the most pathogenic fungi such as Candida. A methodical structure-activity relationship review of several major fragments of these highly functionalized molecules is described. This infor­
mation is useful for determination of the minimum functional/structural requirements for design of an optimal compound in this series. Analogs are presented with their accompanying whole cell antifungal activities.
Drugs Acting on DNA Topoisomerases: Recent Advances and Future Perspectives
Authors: Gatto B. , Capranico G. , Palumbo M.
Published: January 2023

DNA-topoisomerases, a family of DNA-processing enzymes, represent the pharmacological target of major clinically useful chemotherapeutic agents. These drugs essentially act by trapping a topoisomerase-DNA cleavable complex, an intermediate in the enzyme's catalytic cycle. Research activity in this field continues to grow exponentially, resulting in a wealth of new information on the functional role and the bio­
chemical and structural properties of the enzymes. In addition, the drug pharmacophores have been further characterized, along with their sequence preferences, and key interactions with the target macromolecules are being unveiled. This review will discuss the recent advances in elucidating the mode of action of DNA­ topoisomerases and of topoisomerase-targeted anticancer agents.
Ring-B Modified Anthracyclines
Authors: Suarato Antonino , Angelucci Francesco , Geroni Cristina
Published: January 2023

One of the most investigated classes of antitumor drugs is represented by anthracyclines. Over thirty years since the original discovery of daunorubicin and doxorubicin thousands of anthracycline analogues have been synthesized and tested to identify compounds superior to the parent drugs in terms of increased therapeutic effectiveness, reduced toxicity or both. Previous structure-activity studies had shown that minor modifications of the anthracycline structure can result not only in active agents, but,
more importantly, analogues with reduced cardiotoxicity and activity on multi drug resistance. The fact that 4- demethoxydaunorubicin showed higher potency than c.launorubicin and a reduced cardiotoxicity, prompted us to explore novel analogues with altered substitution patterns on the anthraquinone system, particularly ring-B. In this review we will describe total synthesis and antitumor activity of three classes of derivatives: whereby one hydroxyl group in ring-B was either removed or replaced with nitro or amino groups. While these modifications yielded anthracyclines with a promising pharmacological activity, they did not modify activity on multidrug resistant (MDR) tumors. On the other hand, introduction of morpholino group in the sugar part of these new molecules, dramatically increased activity on MDR tumors. We conclude that activity on MDR tumors is not bound to modifications in the aglycone moiety of anthracyclines.
Use of Second-Generation Basal Insulin Gla-300 in Special Populations: A
Narrative Mini-Review
Authors: Ghosh Sujoy , Kalra Sanjay , Bantwal Ganapathi , Sahay Rakesh Kumar
Published: January 2023

Background and Aims:

Hypoglycemia and insulin-related adverse events are crucial
barriers to effective diabetes management, particularly in the elderly, people with renal impairment,
people with diabetes fasting during Ramadan, or people with type 1 diabetes mellitus
(T1DM). There is a scarcity of clinical and real-world evidence assessing the effectiveness and
safety of insulin glargine 300 U/mL (Gla-300) in these special populations. To understand the entirety
of evidence, this mini-review elaborates on the use of Gla-300 in diabetes management
among special populations.

Methods:

Clinical and real-world evidence related to the use of Gla-300 among special populations
with diabetes were retrieved using PUBMED and Google Scholar.

Results:

Gla-300 has shown improved glycemic control with stable insulin action and low risk of
hypoglycemia in diverse groups with diabetes. It also appears to have an acceptable safety profile
during Ramadan fasting. However, adequate monitoring and adjustment of insulin dose on an individual
basis should be considered.

Conclusion:

Gla-300 is a second-generation basal insulin with proven benefits of reduced risk of
hypoglycemia and improved glycemic control in special populations of people with diabetes.
Clinical Characteristics and Stone Types of Patients with Kidney Staghorn Stone in a Tertiary Referral Center in Iran
Authors: Sharifiaghdas Farzaneh , Taheri Maryam , Nikravesh Nadia , Ahmadzade Mohadese , Dadpour Mehdi , Narouie Behzad
Published: January 2023

Objective:

In the past, infectious agents were assumed to be the leading cause of staghorn stones. The metabolic factors were thought to be a secondary cause. However, recent research has shown that any stone can fill the pelvis and calyces in the same manner as a staghorn stone. This retrospective study investigated the relationship between the staghorn stone’s chemical composition and patients’ demographic characteristics by analyzing the stone samples.

Methods:

The medical records of 170 patients with staghorn stones were studied from a tertiary referral center in central Iran. Then, the specimens of their stones were sent to the laboratory for infrared spectroscopy and x-ray powder diffraction analyses.

Results:

The mean age and body mass index were 49.66 years and 29.1 kg/m2, respectively. Men comprised the majority of patients. Of the entire cohort, 13.6% had diabetes, and 28.6% had hypertension. Sixty-eight of the stones were pure stones. Calcium oxalate and uric acid constituted the majority of the pure stones. Only 1.7% of the pure stones were composed of struvite. Most of the non-pure or mixed stones were composed of uric acid plus a small composition of calcium oxalate or phosphate.

Discussion:

However, 16.% of the mixed stones were struvites, confirming a metabolic background. In the adjusted model (age, BMI, presence of hypertension), patients with diabetes have a 14-fold higher chance of developing a mixed stone (P= 0.018; OR:14.113; CI=1.582-125.924).

Conclusion:

The complete staghorn stone forms for the same reasons as other kidney stones. It appears that infectious background is not the predominant cause in the current era. Alterations in living conditions and nutrition might also be a reason which requires further investigation.
The Use of Unripe Banana Flour as a Functional Feed Ingredient on Blood Profile, Serum Biochemical and Intestinal Indices of Broilers
Authors: Sugiharto Sugiharto , Rahmawati Oktafia Munita , Yudiarti Turrini , Widiastuti Endang , Wahyuni Hanny Indrat , Sartono Tri Agus , Agusetyaningsih Ikania , Ayasan Tugay
Published: January 2023

Background:

The study evaluated the effect of unripe banana flour (UBF) given individually or in combination with probiotics or multienzymes on blood profile, serum biochemical parameters and intestinal indices of broilers.

Methods:

About 392 broiler chicks were assigned to four groups (each with seven replicates) including CONT (birds provided with control feed), UBF (birds provided with 5% UBF in feed), UBFPRO (5% UBF plus 0.05% probiotics) and UBFZYM (5% UBF plus 0.05% multienzyme). Blood and intestinal segment and digesta were collected on days 21 and 38.

Results:

On day 21, the mean corpuscular volume (MCV) value in UBF was lower (p < 0.05) than UBFPRO. At day 38, haemoglobin levels in UBFZYM were higher (p < 0.05) than in CONT and UBF. Mean corpuscular haemoglobin (MCH) and mean corpuscular haemoglobin concentration (MCHC) were higher (p < 0.05) in UBFZYM than in the other groups. UBFZYM had higher (p < 0.05) leukocyte counts than CONT. Uric acid levels in UBFZYM were lower (p < 0.05) than in CONT on day 21. On day 38, UBFPRO chicks had lower (p = 0.05) pH values in the duodenum than other groups. UBFZYM had higher (p = 0.05) pH values in the ileum, while UBFPRO had higher (p = 0.05) pH values in the caecum than the CONT groups. Lactic acid bacteria were found in higher (p < 0.05) concentrations in the ileum of UBFPRO and UBFZYM than in the CONT at day 38. The lactic acid bacteria to coliform ratio in UBFPRO and UBFZYM ileums was also higher (p = 0.07) than in CONT. On day 38, the crypt depth of the duodenum in UBFZYM was lower (p < 0.05) than in CONT. The duodenum villus height to crypt depth ratio was higher (p < 0.05) in UBFZYM than in the other groups. The villus height to crypt depth ratio in the UBF ileum was higher (p < 0.05) than in the CONT. When compared to CONT broilers, UBF, UBFPRO, and UBFZYM broilers had higher (p < 0.05) daily weight gain and feed efficiency.

Conclusion:

Broiler growth performance was improved when UBF was given alone or in combination with probiotics or multienzymes. The use of probiotics or multienzymes in combination with UBF improved the intestinal bacterial population, while multienzymes improved broiler physiology and intestinal morphology.
Chemistry Characterization and Application of Nanocrystals-based Drug
Delivery System: Present to Future Perspective
Authors: Dhibar Manami , Chakraborty Santanu , Kundu Abhijeet , Laha Payel
Published: January 2023

With the development of new technologies, various drugs with higher efficacy have
been found, but their therapeutic use is still limited owing to poor water solubility, which leads to
poor systemic bioavailability. Currently, about 40% of newly discovered drugs have a solubility
issue. It is a major challenge for formulation scientists to overcome this problem and make a robust
and effective formulation. One such unique approach is to formulate the drug as nanocrystals
which alter the physical characteristics of the drug, resulting in the development of a novel formulation
strategy for poorly soluble drugs. Nanocrystals are produced by various techniques such as
top-down, bottom-up, or combination methods. Nanocrystals improve the clinical application of
problematic drug molecules by decreasing the particle size, enhancing the dissolution rate and
reducing the dose requirement, etc. This approach is not only improving the bioavailability of the
drug but also facilitates the drug targeting to specific sites due to its feasibility of surface modification
and all administration routes. This article deals with the various aspects of nanocrystals including
chemistry, production, stabilization, characterization, and application in the field of pharmacy.
THE EFFECT OF HEALING ENVIRONMENT PRINCIPLES ON STRESS LEVEL OF COVID-19 PATIENTS (CASE STUDY AT HOSPITAL X)
Authors:   Universitas Brawijaya, Ernawati Cicilia , Pratama I Wayan , Pradana Endy , Suryaningati Engerlbertha , Harijanto Natasya , Haripradianto Tito
Published: January 2023

During the COVID-19 pandemic, hospitals are required to provide unique isolation rooms for confirmed COVID-19 patients. This study aims to determine the effect of the healing environment principle on designing an isolation room without a ventilator on the patient's stress level. This research is descriptive qualitative using Focused Group discussion with COVID-19 ex-patients. The study was conducted at Hospital X in May 2021. The results showed that the things that helped reduce stress in patients were the presence of a garden outside the isolation room and good quality linen, clean fragrance, and disinfectant, which made the patient confident about the cleanliness of the room. Meanwhile, what causes stress is the noise of the exhaust fan, dull paint color, lack of privacy in the isolation room, the smell of the bathroom that is not pleasant, and the food's taste is not good. This study concludes that the balance of natural and psychological elements in the arrangement of the COVID-19 isolation area and room can affect the thoughts, feelings, and behavior of patients treated in the COVID-19 isolation room.
Editorial
Authors: Silva Riquer Jorge , Escalante Amor Mildred
Published: January 2023

Los estudios realizados sobre la Hacienda Pública de la América hispánica se han abocado principalmente a analizar la problemática que enfrentó la formación del estado nacional a lo largo de los siglos XIX al XXI; el interés principal ha sido cómo constituir un ministerio que responda a las necesidades que implica tener una organización liberal, en cualquiera de sus formas. Por ello esos trabajos nos han permitido tener una interpretación sólida de ese proceso y de los avatares a los que se han enfrentado en ese tiempo los diversos gobiernos. Si bien podemos decir de manera general que los grupos de especialistas, numerosos por cierto, se han abocado al periodo de la transición, ya sea la del siglo XVIII al XIX o bien la del siglo XIX al XX, con periodos intermedios poco trabajados, sobre todo en el siglo XX por los historiadores, no ha sido así para otros especialistas. El avance ha sido considerable y hemos podido entender mucho de la Hacienda Pública, sus conflictos, su construcción y problemas que hoy día están en la discusión de los gobiernos.
La transición de la Real Hacienda a la Hacienda Púbica en Durango (México), 1810-1835
Authors: Bueno Hurtado Edgar
Published: January 2023

Este artículo propone que la perspectiva regional brinda una visión privilegiada para entender el tránsito de la Real Hacienda a la Hacienda Pública. En México, el periodo conocido como Primera República Federal (1824-1835) implicó la novedad de la soberanía fiscal estatal. Pero la inédita organización se formó a partir de la redistribución de los antiguos rubros fiscales del periodo virreinal y de las novedades surgidas a consecuencia de la guerra civil novohispana de 1810, la Constitución gaditana y durante el Primer Imperio mexicano. Así, este estudio presenta un recorrido por el sistema de gobierno y administración de los impuestos y rentas desde 1810 hasta 1835 en una de las entidades de la joven nación: el Estado de Durango.
Emotional reactions of people who stutter in difficult communication situations: a preliminary study
Authors: Koçak Ayşe Nur , Cangi M. Emrah
Published: January 2023

Purpose: Few studies have examined the emotional responses of adults who stutter (AWS) in specific situations. The aim of this study is to determine the emotions of AWS in different communication situations at various times in communication.Methods: The study included 38 AWS. The first stage of the study determined the difficulties related to stuttering in communication situations by requiring the participants to complete a questionnaire consisting of open-ended questions. The four SLTs scored these situations from various aspects (e.g., common experience of difficulty for AWS) and the final version of the 19-item list of situations in the “Determining Emotions Regarding Communication Situations in Stuttering Questionnaire (DERCSQ)” has been reached. The DERCSQ also provided a list of 90 emotions related to communication situations and stuttering. The participants completed the DERCSQ by indicating their feelings in three communication situations (before, during, and after communication).Results: The results indicated that AWS frequently experience negative emotions in different communication situations. The participants indicated that they experience the following emotions in pre-communication: excited (194), anxious (143), restless (142), tense (128), and concerned (118). During the communication, the participants experience the following emotions: uneasy (90), excited (88), uncomfortable (81), insufficient (78), and restless (75). During the after-communication period, the participants indicated that they experience the following emotions: anxiety (38), uneasy (34), uncomfortable (34), insufficient (33), and self-rage (32).Conclusions: The emotions obtained are compatible with the stuttering and psychology literature, it is remarkable that emotions such as anxiety and uneasy after stuttering were prominent.
Detección de periodos de crisis del NASDAQ con EEMD - AE
Authors: Estrada Sánchez Gerardo , Hernández Álvarez Federico , Camacho Ardila Andrés Giovanni
Published: January 2023

Se propone identificar el inicio y terminación de las crisis por SARS-CoV-2 y subprime en el NASDAQ. Se utilizó el EEMD para la descomposición del índice en series consecutivas con el mismo número de componentes y se calcularon sus coeficientes de correlación, también se analizó el espectro de potencia de la serie original. Se identificaron señales de inestabilidad asociadas a cambios tanto en las correlaciones de los componentes como del espectro del NASDAQ. Se recomienda aplicar el procedimiento sobre otras series y otras crisis; asimismo, el método se basa en la detección de discrepancias, lo que implica ser una herramienta de monitoreo, mas no una de pronósticos cuantitativos. La originalidad del trabajo radica en el uso del EEMD modificado para la descomposición de series consecutivas en el mismo número de componentes, y la utilización del coeficiente de correlación entre componentes y el espectro de la serie original como medidas de estabilidad del sistema. El enfoque mostró ser útil para identificar y anticipar grandes cambios en el comportamiento de una serie de tiempo.
Prevention of Unplanned Hospital Admissions in Multimorbid Patients Using Computational Modeling: Observational Retrospective Cohort Study
Authors: González-Colom Rubèn , Herranz Carmen , Vela Emili , Monterde David , Contel Joan Carles , Sisó-Almirall Antoni , Piera-Jiménez Jordi , Roca Josep , Cano Isaac
Published: January 2023

Background

Enhanced management of multimorbidity constitutes a major clinical challenge. Multimorbidity shows well-established causal relationships with the high use of health care resources and, specifically, with unplanned hospital admissions. Enhanced patient stratification is vital for achieving effectiveness through personalized postdischarge service selection.

Objective

The study has a 2-fold aim: (1) generation and assessment of predictive models of mortality and readmission at 90 days after discharge; and (2) characterization of patients’ profiles for personalized service selection purposes.

Methods

Gradient boosting techniques were used to generate predictive models based on multisource data (registries, clinical/functional and social support) from 761 nonsurgical patients admitted in a tertiary hospital over 12 months (October 2017 to November 2018). K-means clustering was used to characterize patient profiles.

Results

Performance (area under the receiver operating characteristic curve, sensitivity, and specificity) of the predictive models was 0.82, 0.78, and 0.70 and 0.72, 0.70, and 0.63 for mortality and readmissions, respectively. A total of 4 patients’ profiles were identified. In brief, the reference patients (cluster 1; 281/761, 36.9%), 53.7% (151/281) men and mean age of 71 (SD 16) years, showed 3.6% (10/281) mortality and 15.7% (44/281) readmissions at 90 days following discharge. The unhealthy lifestyle habit profile (cluster 2; 179/761, 23.5%) predominantly comprised males (137/179, 76.5%) with similar age, mean 70 (SD 13) years, but showed slightly higher mortality (10/179, 5.6%) and markedly higher readmission rate (49/179, 27.4%). Patients in the frailty profile (cluster 3; 152/761, 19.9%) were older (mean 81 years, SD 13 years) and predominantly female (63/152, 41.4%, males). They showed medical complexity with a high level of social vulnerability and the highest mortality rate (23/152, 15.1%), but with a similar hospitalization rate (39/152, 25.7%) compared with cluster 2. Finally, the medical complexity profile (cluster 4; 149/761, 19.6%), mean age 83 (SD 9) years, 55.7% (83/149) males, showed the highest clinical complexity resulting in 12.8% (19/149) mortality and the highest readmission rate (56/149, 37.6%).

Conclusions

The results indicated the potential to predict mortality and morbidity-related adverse events leading to unplanned hospital readmissions. The resulting patient profiles fostered recommendations for personalized service selection with the capacity for value generation.
International spread of antimicrobial resistance in 2022: Genomic surveillance of multidrug-resistant isolates from Ukrainian Patients in a German health facility (Preprint)
Authors: Stein Claudia , Zechel Maria , Spott Riccardo , Pletz Mathias W. , Kipp Frank
Published: January 2023

BACKGROUND

Experts are increasingly sounding the alarm: the ongoing war in Ukraine could lead to the spread of antimicrobial resistance across Europe.

OBJECTIVE

Our report focused on the genomic analysis of multi-drug resistant pathogens collected from Ukrainian soldiers and refugees who were treated in a German hospital.

METHODS

In 2022, seven Ukrainian war-injured soldiers were admitted to our tertiary care hospital. Upon admission, screening samples and samples from the focus of suspected infection were taken. At our 1400-bed hospital, we have implemented a routine whole genome sequencing for all carbapenemase-producing Gram-negative bacteria (CP-GN), regardless of whether colonization or infection occurred.

RESULTS

All Ukrainian patients were infected or colonized with at least one carbapenemase-producing Gram-negative bacteria, including carbapenemase-producing K. pneumoniae, P. aeruginosa, A. baumannii, Providencia stutartii, C. freundii, and E. coli. Genomic surveillance revealed that i) detected carbapenemases were mostly NDM-1 and OXA-48 – which are not inhibited my most of the novel carbapenemase-inhibitors, ii) a C. freundii isolate with mcr-9 resistance gene conferring resistance to colistin and iii), we mostly detected isolates belonging to sequence type 395 (7/13) among the Ukrainian K. pneumoniae isolates.

CONCLUSIONS

Migration resulting from the ongoing Ukrainian war will expedite the dissemination of hard-to-treat carbapenemase-producing pathogens. Our experience suggests that screening and preventive isolation upon admission is essential for the care of Ukrainian patients in order to prevent the entry of hard-to-treat carbapenemase-expressing bacteria into the hospital.
Evaluasi Kekuatan Mesin Bubut Akibat Gaya Pemakanan Pada Ujung Alat Potong
Authors: Setiono Adhi Tri , Muflikhun Muhammad Akhsin , Suyitno S
Published: January 2023

Keberadaan mesin bubut berperan penting pada pekerjaan pemesinan. Di sisi lain permintaan mesin bubut yang semakin meningkat di Indonesia terutama pada Industri Kecil dan Menengah bidang manufaktur. Namun, mayoritas mesin bubut yang beredar di Indonesia saat ini merupakan mesin bubut impor. Oleh karena itu diperlukan satu upaya perancangan dan pembuatan mesin bubut untuk memenuhi kebutuhan industri tersebut. Pada penelitian ini dilakukan evaluasi kekuatan mesin bubut skala kecil hasil perancangan. Evaluasi ini dilakukan dengan pendekatan analisis elemen hingga. Hasil evaluasi dapat digunakan sebagai acuan untuk mengetahui kekuatan mesin bubut sebelum dilakukan proses produksi. Parameter rata-rata pemakanan dan kedalaman pemotongan diterapkan pada simulasi. Kondisi pemotongan ditentukan untuk mendapatkan gaya pemakanan,  gaya radial, dan gaya tangensial. Gaya-gaya diterapkan pada ujung alat potong sesuai dengan kondisi pembubutan sebenarnya. Hasil evaluasi menunjukkan gaya-gaya pada proses pemakanan tidak berdampak apapun pada rangka mesin bubut dan pada bagian pemegang pahat tidak terjadi gaya dan defleksi yang signifikan.
The Impact of Leadership Styles on Teachers’ Stress at Work Place
Authors: Roseni Dr. Emilda , Tirana Dr. Jonida
Published: January 2023

This study examines the impact of leadership styles on teachers’ stress on five schools in Tirana, Albania. Leadership styles and stress are the most important factors that affect the efficiency of teaching.This research paper aims to investigate how age, gender and educational differences influence the teachers’ reaction to interpret and react to the leadership characteristics of their headmasters. A quantitative research method was employed and a questionnaire was chosen as an instrument to collect the data for this research. The questionnaires were distributed to the schools and a total of 102 valid responses were received. The population of this study includes 102 full time and part time teachers in five 9-year-schools located in the city of Tirana. 25 questionnaires were collected at “De Rada” school, 24 questionnaires at “Fan Noli”, 20 questionnaires at “Emin Duraku”, 10 questionnaires at “Mihal Grameno” 23 questionnaires at “Skënder Caci” school, in the district of Tirana, Albania. The collected data was entered into SPSS version 25 for statistical analysis using descriptive and analytic methods.In the findings of this study, there was a substantial positive relationship between leadership style and stress at work. As a conclusion, we can affirm that the results of this research will serve to further studies that have to be carried out in pursuit of expanding the leader’s roles and strategies in order to improve working conditions, have more motivated and satisfied teachers in the schools where they work.
El estigma del deportado. Un acercamiento a su representación en la caricatura política
Authors: Gómez Cabrera Alejandra Patricia
Published: January 2023

La política antimigratoria defendida por el presidente Donald Trump, ha sido criticada por la retórica estigmatizante y agresiva con la que retrata a los inmigrantes, especialmente a quienes enfrentan un proceso de deportación en ese país. La construcción de un muro fronterizo, las deportaciones masivas, las condiciones de hacinamiento y vejaciones de los centros de detención, la persecución de indocumentados y la restricción de visas son algunos de los puntos que caracterizan esta propuesta.

Erving Goffman es uno de los principales estudiosos de la sociología de la desviación. En su teoría propone analizar el estigma como un recurso de cosificación del otro y de legitimación de la violencia hacia el mismo. Michel Foucault es otro de los analistas que propone comprender el estigma como una tipología del anormal en términos de su identidad física y moral, al representarlo como alguien peligroso y dañino para el bienestar social. En México, los cartones políticos han retratado de un modo irónico el discurso estigmatizante con el que se representa a los inmigrantes en la política de Trump.

A través del análisis de los mecanismos de estigmatización representados en los cartones políticos publicados por caricaturistas como Rafael Barajas Durán, “El Fisgón”; Antonio Helguera, “Helguera”; José Hernández, “Hernández”; Bulmaro Castellanos Loza “Magú” y Gonzálo Rocha, “Rocha”, en el periódico nacional La Jornada, durante los dos primeros años del mandato presidencial de Donald Trump, es posible identificar la cosificación, la descapitalización y la criminalización de la que son sujeto los inmigrantes deportados.
Las estrategias de respuesta, la protección de los derechos de los trabajadores y la gestión del cambio de empresas mexicanas ante la crisis por el Covid-19
Authors: Fierro Moreno Eréndira
Published: January 2023

Ante la contingencia de salud y económica en que se encuentra la sociedad, el presente artículo tiene como objetivo determinar en qué medida las estrategias de respuesta y los derechos de los trabajadores influyen en la gestión del cambio ante la crisis por Covid-19. La metodología que se utilizó fue la aplicación de un modelo de regresión múltiple con datos obtenidos de la Encuesta de Estrategias de Respuestas de Empresas Mexicanas (EEREM) 2020 que está basada en un muestreo no probabilístico (por conveniencia-sujetos voluntarios) a 109 empresas de México; cuya unidad de análisis fue en su mayoría mandos directivos y medios. Los resultados comprueban que las estrategias de respuesta y la protección de los derechos de los trabajadores ante la crisis por Covid-19 predicen que la gestión del cambio es un elemento para que las empresas enfrenten los nuevos desafíos. Aunado a lo anterior, este estudio confirma una relación positiva y significativa de las estrategias de respuesta en los procesos de gestión del cambio que son necesarias en las empresas ante la crisis por Covid-19.
Incorporación de los principios de la perspectiva latinoamericana de los derechos humanos a la ciencia posnormal para la gestión del riesgo ambiental en América Latina
Authors: Aguirre García Gabriela J. , Tristán Rodríguez Suhey , Hernández-Martínez Ricardo , Lizardi-Jiménez Manuel Alejandro
Published: January 2023

En América Latina, la gestión del riesgo ambiental y la efectivización de los derechos humanos tienen retos teóricos por superar. Uno de ellos es la colonialidad epistémica que se transfiere de la gestión ambiental vía el mercado y por la vía formal de los derechos humanos. A la luz de la actual amenaza ambiental y de la vulneración permanente de los derechos humanos en Latinoamérica es importante considerar los conocimientos de los pueblos históricamente colonizados. La integración de nuevos conocimientos puede significar un elemento clave para alcanzar al mismo tiempo que la sustentabilidad ambiental, la efectivización de derechos humanos. Dado que desde el campo de la economía y de los derechos humanos existen propuestas teóricas que superan la colonización epistémica, pero independientes la una de la otra, el objetivo de este documento es incorporar algunos principios de la perspectiva latinoamericana de los derechos humanos a la guía decisional de la ciencia posnormal, para generar un marco teórico robustecido en conceptos que protejan el aspecto pluricultural de los pueblos latinoamericanos. La metodología que se utiliza es la interdisciplina. Se interconectan algunos principios de la perspectiva latinoamericana de los derechos humanos con los criterios metodológicos de la ciencia posnormal.
Conocimiento icónico y demostración. Crítica al valor deíctico de la imagen científica
Authors: Reyes Cruz Marco Antonio
Published: January 2023

Este artículo pretende discutir la noción de conocimiento icónico del filósofo Gottfried Boehm. Para ello se analizará en un primer momento la argumentación sobre el conocimiento icónico de Boehm así como su noción de esquema como demostración visual. En un segundo momento argumentaré cómo somos capaces de reconocer conceptos, abstractos e invisibles, en modelos así como la posibilidad de juzgarlas como verdaderas o falsas. En un tercer momento se abordará el acercamiento de Dieter Mersch a las imágenes científicas y su capacidad demostrativa así como los obstáculos metodológicos y teóricos a los que debe enfrentarse un conocimiento icónico.
Discrete formulation of envelope correlation coefficient for faster analysis in MIMO antenna systems
Authors: Fritz Andrade Erik , Pérez Miguel Ángel , Tirado Méndez José Alfredo , Vasquez Toledo Luis Alberto , Marcelin Jimenez Ricardo , Rodriguez Colina Enrique , Pascoe Chalke Michael
Published: January 2023

In this paper, an easy-to-program mathematical expression to compute the Envelope Correlation Coefficient (ECC) between two antennas by using their radiated electric fields at the far-field region is derived. The main advantage of the resulting algorithm is its higher speed to obtain results compared to those used in commercial software. This novel approach presents a discrete equation that can be employed after obtaining the electric field in spherical coordinates by computer simulations. Thus, another alternative arises to report this metric for low or high radiation efficiency antennas, instead of the less accurate S-parameter-based equation, which does not ensure high accuracy when low radiation efficiency antennas are under study. A comparison between the presented algorithm and the results given by commercial software is shown and discussed, in which is clearly observed that the results are greatly convergent, but with the advantage of achieving a lesser time computing period by the proposed method.
Integración de una cámara multiespectral y aprendizaje automático para clasificación de manzanas
Authors: Gante Diaz Saulo Abraham , Lozano Hernández Yair , Maldonado Trinidad Marco Antonio , Flores Colunga Gerardo Ramon , Villegas Piña Daniel
Published: January 2023

Este trabajo presenta un sistema capaz de realizar una clasificación binaria (buena y podrida) de manzanas red delicious, lo cual se logra mediante el uso del Índice de Vegetación de Diferencia Normalizada (NDVI) y una Red Neural Xception. Para ello, se utiliza una cámara multiespectral para observar detalles fuera del alcance del ojo humano, reduciendo la presencia de errores durante su clasificación. La selección del NDVI es resultado de su comparación con los índices de vegetación GNDVI, GVI, NDRE, NDVIR, NG, NGRDI y RVI, aplicados a un banco de imágenes obtenido mediante la cámara multiespectral. Además, se muestran los resultados de la clasificación al utilizar redes neuronales Xception, ResNet y MobileNet, lo que justifica el uso de la red Xception. Finalmente se describe la instrumentación e iluminación empleada en un prototipo que emula el proceso de clasificación real utilizando una banda transportadora, lo que permite validar de forma experimental el sistema de clasificación propuesto, obteniéndose un 73 % de éxito en la clasificación en línea. El desarrollo de este trabajo se basa en la siguiente metodología: Se utiliza una cámara multiespectral para la creación de una base de datos, las imágenes obtenidas pasan a una etapa de procesamiento conformada por la alineación y reconstrucción RGB. Posteriormente, se utilizan dos o más bandas para el cálculo, comparación y análisis de diferentes índices de vegetación. Una vez determinado el índice de vegetación a utilizar, se procede al entrenamiento y comparativa entre distintas arquitecturas de redes neuronales. Respecto a la etapa de entrenamiento, se emplea transferencia de aprendizaje para reducir la necesidad de una gran base de datos. Por último, se realizan pruebas experimentales para validar el comportamiento
Eficiencia de la Piedra Pómez (P-HU) como absorbente de humedad capilar para la salvaguarda de acervos documentales
Authors: Robles Camacho Jasinto , Sereno Villaseñor Hugo Iván , Cortes Esquivel Jose Luis , González Garrido Ricardo Miguel Ángel , Pola Villaseñor Antonio , Cedillo Rodríguez Fidel
Published: January 2023

La ciudad de Morelia es la capital del estado de Michoacán de Ocampo (México), declarada patrimonio cultural de la Humanidad por la UNESCO en 1991. Entre las características de su centro histórico destaca la uniformidad de roca ignimbrítica color rosa, usada como material constructivo recubierto y sillares. Sin embargo, el problema de humedad por ascenso capilar afecta considerablemente a los inmuebles del Centro Histórico a través de dos factores principales: 1) la porosidad de la roca, que promedia los ~10 µm y tiene una conectividad del orden del 80% y, 2) niveles freáticos someros con una alta tasa de recarga acentuada durante el periodo de lluvias (mayo a junio).

Entre las características de esta importante ciudad colonial, se cuenta el resguardo común de acervos documentales y bibliotecas tanto públicas como particulares. Uno de ellos es el archivo de la Sección de Monumentos Históricos del Centro INAH Michoacán, integrado desde hace más de cuatro décadas, que concentra sistemáticamente los datos constructivos e intervenciones en inmuebles del siglo XVI al XIX de todo el estado. Este acervo ocupa un espacio específico en la planta baja del inmueble conocido como Palacio Federal de Morelia, donde la humedad por ascenso capilar es intensa. Para intentar minimizar o desaparecer la humedad que ponía en riego este importante acervo, se aplicó una metodología con materiales naturales, donde el uso de piedra pómez hizo eficiente el proceso de resguardo del acervo. Luego de una serie de pruebas, se observó que la piedra pómez P-HU muestra valores de r en el rango de las rocas de composición riolítica, sin embargo, su ρb se encuentra en un rango < 1g/cm3, menor a la densidad del agua y directamente relacionada con su alta porosidad. Asimismo, la interconectividad entre poros es del orden de ⁓70%, donde se resalta que la dinámica hídrica de la pómez está relacionada y acotada únicamente por la porosidad accesible al agua. Con base en los resultados generales, las propiedades hídricas están vinculadas estrechamente con la distribución, el tamaño e interconexión de los poros de la pómez. En la práctica, el material en cuestión es altamente eficiente y permite proyectarlo como una opción confiable para la captura de humedad en espacios donde, particularmente, se resguardan libros o documentos de valor cultural o histórico; sin que sea la única aplicación de este material con posibilidades de éxito.
The Impact of Stock Market on Indian Economy
Authors: Devade Omkar Namdev , Gavali Vikas Chandrakant , Jadhav Asst. Dr. Prof. S.P. , Thorat Asst. Prof. S. V.
Published: January 2023

Abstract: The Third Largest within the world of Indian Economy in terms of buying power. it's going to touch new heights in coming back years. The Global investment Bank , by once North American country and China 2035 India would third largest economy of the globe. it'll grow to hour of size of the North American country economy. This booming economy of nowadays must pass through several phases before it will bring home the bacon the current milestone of Sept. 11 gross domestic product. Movements within the stock exchange will have a profound economic impact on the economy and individual shoppers. A collapse in share costs has the potential to cause widespread economic disruption. This paper deal s with stock market play very important role growth of Indian Economy and additionally the Impact stock exchange on Indian Economy by approach of Conceptual Methodology exploitation to the Journals of Indian stock exchange.
Reliability analysis of compressed timber studs on the buckling criterion
Authors: Solovev Sergey A. , Inkova Yulia A. , Soloveva Anastasia A.
Published: January 2023

Introduction. Ensuring safety is a priority goal in the design, construction and operation of building and structures. A quantitative assessment of safety can be the failure probability of a structural element. The article presents algorithms for reliability analysis of timber studs by the buckling criterion under central compression force.

Materials and methods. The FOSM (First Order Second Moment) method is a classic approach for solving many reliability analyses tasks in the engineering sector. This method uses the second statistical moments of random variables (mathematical expectation and variance) and the method of statistical linearization with the decomposition of the function into a Taylor series of the first order. However, it is often necessary to deal with nonlinear limit state functions, where the statistical linearization method can lead to incorrect results. In this case, it is necessary to use other algorithms for reliability analysis: the Hasofer – Lind method, SORM (Second Order Reliability Method), etc.

Results. The numerical example of reliability analysis for compressed timber studs on the buckling criterion is considered. To illustrate the problem of the research, the dimensions of the cross-section of the studs and the strength of the wood are taken as random variables, and the load is considered a deterministic value. In the following, an algorithm for reliability analysis is described for a timber studs under random load. The classical FOSM approach showed an overestimated reliability index by 35 % compared to the results of the Monte Carlo numerical experiment and the analytical solution using the Hasofer – Lind algorithm.

Conclusions. The use of the traditional FOSM method for reliability analysis of wooden studs according to the buckling criterion can lead to overestimated reliability index estimates. It is unacceptable from the point of view of the structural safety. The calculation and analysis of the reliability of timber studs should be carried out on the basis of the Hasofer – Lind algorithm, the SORM method or other optimization methods.