bluuebunny/crossref_metadata_2025 huggingface dataset:
Pendampingan belajar pada sekolah yang terdampak gempa di Cianjur melalui program GISMA
Authors: Apsari Yanuarti , Putri Anastasya Permatasari , Setiadi Anita Puteri , Ridwan Andini Fitriani , Fazriah Fanny Nur , Rosadi Mutia Amelia , Yunia Rika
Published: November 2023

Gempa bumi di kabupaten Cianjur telah merusak banyak sekolah-sekolah sehingga mengakibatkan roses Kegiatan Belajar Mengajar terganggu. Salah satu bentuk pemulihan korban gempa cianjur adalah dengan memberikan pendampingan belajar bagi siswa-siswa di sekolah yang terdampak bencana. Kegiatan pendampingan belajar ini bertujuan untuk membantu membangun kembali semangat dan motivasi belajar bagi siswa korban gempa di SMPS PGRI Warungkondang, Cianjur. Metode pelaksanaan dari kegiatan ini terdiri dari tiga tahap yaitu tahap observasi, tahap perancangan dan pengembangan serta tahap pelaksanaan. Adapun kegiatan pendampingan belajar sendiri yang dilaksanakan di SMPS PGRI Warungkondang, tidak hanya membantu proses pembelajaran di kelas saja tetapi juga membantu kegiatan ekstrakulikuler seperti paskibra, pramuka, tari, voli, futsal, dan paduan suara. Hasil dari kegiatan ini adalah antusiasnya anak-anak dalam mengikutyi setiap kegiatan yang dilaksanakan oleh tim GISMA. Sehingga dapat disimpulkan bahwa kegiatan pendampingan belajar ini memberikan efek yang positif karena dapat menciptakan suasana menyenangkan bagi anak-anak korban pasca gempa di Kecamatan Warungkondang, Cianjur.
Pelatihan aplikasi gamifikasi interaktif berbasis budaya untuk meningkatkan minat siswa memproduksi karya bahasa Indonesia
Authors: Azzahra Iis Siti Salamah , Rostikawati Yeni
Published: November 2023

Artikel ini menjabarkan program pengabdian yang bertujuan untuk mensosialisasikan dan memberikan gambaran tentang penggunaan aplikasi gamifikasi interaktif berbasis budaya tradisional bagi guru dan siswa di SMA Kota Cimahi. Hal ini dilatarbelakangi oleh salah satu permasalahan yang dihadapi pada pembelajaran Bahasa Indonesia yang membutuhkan inovasi dalam pembelajaran yang dapat meningkatkan minat dalam memproduksi konten bahasa Indonesia khususnya yang berbasis teks. Guru khususnya harus dapat memilih dan menggunakan perangkat pembelajaran yang menarik dengan penggunaan teknologi dan juga aplikasi interaktif tetapi tetap memiliki nilai-nilai karakter berbasis budaya tradisional sebagai alternatif media pembelajaran yang dapat memacu siswa dalam mengikuti pembelajaran dan menghasilkan output pembelajaran yang diharapkan. Metode yang digunakan dalam pengabdian ini adalah metode pendidikan dan pelatihan. Panduan serta pedoman penggunaan aplikasi serta cara membelajarkan yang diberikan pada pelatihan ini diharapkan mampu memberikan rujukan untuk guru maupun siswa dalam menghadirkan pembelajaran yang menarik dan inovatif sehingga siswa termotivasi untuk memproduksi konten bahasa Indonesia yang baik dan berkualitas sesuai dengan tujuan pembelajaran.
Sosialisasi penulisan surat dinas di Kantor Dinas Perhubungan Kota Bekasi
Authors: Bayu Yusril dava
Published: November 2023

Official/Formal letters already have clear formats and rules in writing, but in reality, mistakes are often found that are made repeatedly. Writing that is done in a template or following a previous writing pattern is one of the reasons why the error keeps repeating itself. The purpose of the official letter-writing training at the Department of Transportation Bekasi City is to provide an understanding of the department transportation employees, especially the administrative staff, about writing good and correct official letters. This community service program activity was carried out for two days, namely on 07 April 2023 which took place at the Department of Transportation Bekasi City Office. The administrative Staff of the Department of Transportation who participated in this official letter-writing training totaled 25 people. The socialization method used is direct lectures and questions/answers. Based on the initial identification through the writing process, the writing form of the activity participants still found many errors in spelling and sentences that were less effective, meaning that it is necessary to increase the application of Indonesian spelling in accordance with the current spelling. During the training, the participants and the community service implementation team conducted an evaluation and asked questions directly about the material that had been presented. Then, activity participants understand the mistakes and know the corrections have been submitted by the abdimas team so that participants can properly and correctly compose official letters in accordance with the General Guidelines for Indonesian spelling
Peran artificial intelegent terhadap peningkatan kreativitas siswa dengan menerapkan Projek Penguatan Profil Pelajar Pancasila
Authors: Sucahyo Nur , Usanto Usanto , Sopian Adi
Published: November 2023

Artificial Intelligence (AI) menjadi semakin luas dan tidak terkecuali di dunia pendidikan. AI dapat dimanfaatkan untuk membantu meningkatkan kualitas pembelajaran dan mengembangkan potensi siswa, termasuk dalam bidang kreativitas. Salah satu pendekatan yang dapat dilakukan adalah dengan menerapkan Proyek Penguatan Profil Pelajar Pancasila (P5) yang berbasis AI. Para siswa di sekolah SMA Tunas Harapan Jakarta, belum ada yang menggunakan aplikasi untuk Program Peran Artificial Intelligence (AI) terhadap peningkatan kreativitas siswa. Diperlukan suatu kegiatan berupa Pengabdian kepada Masyarakat dalam memberikan penyelesaian dalam permasalahan terutama bagaimana proses metakognitif scaffolding siswa SMA dalam memecahkan masalah integral dengan menggunakan aplikasi photomath pada E-Learning AI. Tujuan pengabdian kepada masyarakat ini adalah untuk memahami secara mendalam bagaimana proses metakognitif siswa SMA dalam memecahkan masalah integral dengan menggunakan aplikasi photomath pada melalui E-Learning AI. Aplikasi photomath sebagai alat bantu yang dapat meningkatkan kemampuan metakognitif siswa dalam memecahkan masalah integral dalam membantu siswa mengembangkan keterampilan yang diperlukan dan bisa dikembangkan pada kurikulum sekolah.
Mengoptimalkan literasi masyarakat perdesaan melalui seminar pola asuh: Mendidik anak kembali ke fitrah
Authors: Agustiana Vina
Published: November 2023

Mendidik anak bukanlah perkara yang mudah. Kesalahan yang dilakukan orang tua dalam menerapkan model pengasuhan dapat mempengaruhi perilaku anak di kemudian hari. Oleh karena itu, mempelajari prinsip-prinsip pengasuhan yang tepat untuk membentuk karakter positif pada anak-anaknya merupakan hal yang sangat penting bagi orang tua. Pola asuh yang baik dapat membantu menumbuhkan rasa peduli, jujur, mandiri, dan gembira pada anak. Pola asuh yang baik juga dapat menunjang kecerdasan dan melindungi anak dari kecemasan, depresi, pergaulan bebas, penyalahgunaan alkohol dan narkoba. Melalui kegiatan pengabdian kepada Masyarakat, penulis mengadakan kegiatan seminar pola asuh dengan tema Mendidik Anak Kembali ke Fitrah dengan tujuan agar memperluas wawasan peserta serta mengubah cara pandang peserta dalam pola asuh anak. Kegiatan ini melibatkan 37 wali murid di salah satu sekolah taman kanak-kanak di Desa Ciwaru Kecamatan Ciwaru Kabupaten Kuningan. Pemateri yang di undang ialah salah satu praktisi dalam bidang pola asuh anak. Berdasarkan hasil wawancara dengan peserta, ditemukan bahwa: (a) tidak adanya kerjasama yang baik antara ayah dan ibu dalam mendidik anak serta dalam berbagi kewajiban rumah tangga; (b) adanya hukuman verbal dan non-verba, seperti memaki, mencubit bahkan mengunci anak di kamar mandi; (c) anak diasuh oleh orang lain (nenek atau kerabat dekat) dikarenakan orangtua yang bercerai. Adapun setelah adanya kegiatan seminar ini, terdapat kesimpulan bahwa: (a) harus adanya aturan yang diterapkan dirumah terkait kedisiplinan; (b) orangtua harus menjadi role model yang baik bagi anak; (c) adanya komunikasi yang baik antara orangtua; (d) Ketika ayah sedang menasehati anak, maka ibu tidak membela, juga sebaliknya; (e) menghindari hukuman verbal dan non verbal karena berdampak buruk bagi psikologis anak; (f) mencontoh sikap Rasulullah dalam mendidik anak.
Penyuluhan mitigasi bencana melalui media edukasi di Desa Nagrak Kecamatan Cianjur
Authors: Mustika Ika , Alfriandi M. Zaki , Fitriah Nurahman Neng
Published: November 2023

Disaster mitigation counseling through educational media is part of the community service activities organized by IKIP Siliwangi. The counseling aims to provide information, knowledge and understanding to the community about disaster mitigation as an effort to reduce disaster risk and save lives. In addition, to increase public awareness of actions that must be taken pre-disaster, during disasters, and after disasters occur. The method used in counseling includes four stages of activity, which is the service problem identification stage, the service planning stage, the service implementation stage, and the service evaluation stage. The target of the counseling is the community of Nagrak Village, Cianjur Subdistrict, Cianjur Regency, West Java considering that this area is one of the areas that was quite severely affected by the earthquake disaster. Based on interview data and discussions during the service activities, the community showed a positive response to disaster mitigation counseling through the use of educational media.
Prevalência da Disfagia no doente renal crônico com diabetes em serviço de hemodiálise em um hospital público.
Authors: Londero Gabrielly da Silva , Nascimento Ýleris de Cássia de ArrudaMourão , Schincaglia Raquel Machado
Published: November 2023

Introdução: A Doença Renal Crônica (DRC) é considerada uma alteração estrutural e/ou funcional dos rins que contribui para a redução da taxa de filtração glomerular. No Brasil, a hipertensão arterial se mantém como principal doença de base da DRC, seguido do diabetes mellitus (DM). Admite-se que pacientes com DRC possam apresentar alterações nos sistemas e estruturas que estão relacionados com a deglutição, devido a modificações provocadas pelo tratamento ou pela falta dele. Objetivo: Descrever a prevalência de disfagia em doentes renais crônicos em tratamento de hemodiálise que vivem com diabetes e verificar os fatores associados. Método: Trata-se de um estudo transversal, descritivo, de caráter quantitativo, com resultado da aplicação do protocolo GUGGING SWALLOWING SCREEN (GUSS) em indivíduos com doença renal crônica e diabetes em tratamento de hemodiálise, internados no Hospital Estadual Dr. Alberto Rassi (HGG). Resultados: Participaram do estudo 26 indivíduos. A mediana de idade observada nesta amostra foi de 62 (IQR:57-67) anos, observou-se maior frequência do sexo masculino 73% (n=19). Nos testes de deglutição, os participantes apresentaram maior dificuldade na deglutição com a consistência sólida, em que 61,54% (n=16) tiveram deglutição atrasada e 34,62% (n=9) apresentaram tosse involuntária durante a ingesta. No protocolo GUSS a média da pontuação foi de 19 (IQR:18-20) pontos, o que significa uma ligeira disfagia nos indivíduos, com baixo risco de broncoaspiração. Conclusão: Pacientes doentes renais crônicos, em tratamento de hemodiálise, que vivem com diabetes apresentaram baixa frequência de disfagia, com risco mínimo de broncoaspiração, por meio do protocolo GUSS.
Análise do conhecimento autodeclarado e utilização da Classificação Internacional de Incapacidade, Funcionalidade e Saúde (CIF) por docentes fisioterapeutas de uma universidade públicaCuidado farmacêutico em Diabetes Mellitus Tipo 2: um desafio a ser enfrentado.
Authors: Santos Flávia Carine Mattana dos , Costa Marco Antônio , Girotto Edmarlon , Possagno Gerusa Clazer Halila
Published: November 2023

Introdução: Dentre as doenças crônicas não transmissíveis mais prevalentes no panorama atual, o diabetes mellitus desponta não somente como doença de maneira isolada, mas também como resultado das inúmeras das suas complicações. É caracterizado por uma síndrome de etiologia múltipla, com hiperglicemia persistente em decorrência dos defeitos na produção de insulina ou na sua ação sobre as células. Objetivo: Analisar o impacto do Cuidado Farmacêutico no controle glicêmico dos usuários com diagnóstico de diabetes mellitus tipo 2 (DM2). Método: Estudo quantitativo que analisou desfechos clínicos como glicemia de jejum, hemoglobina glicada e microalbuminúria em pacientes com diagnóstico de DM2. Resultados: Dos 17 participantes, 11 eram do sexo feminino (64,7%), com média de idade de 60,4 anos (dp ± 10,7), variando entre 41 e 79 anos. Ocorreu uma discreta redução na média dos resultados de HbA1c depois do cuidado farmacêutico, passando de 9,9% no início do estudo para 9,2% ao final dele. Entretanto, houve uma melhora clinicamente importante nos níveis de HbA1c em 58,8% dos pacientes, podendo chegar a 53% de redução para um dos indivíduos acompanhados. Conclusões: Bons resultados foram evidenciados durante o processo de cuidado farmacêutico em usuários com DM2, onde verificou-se a diminuição dos índices de hemoglobina glicada clinicamente importantes, o que influencia na redução das complicações decorrentes da doença.
Analysing sustainability report using GRI index for fundamental labour rights and corporate governance
Authors: Santoso Budi , Damayanti Cacik Rut , Utami Rachma Bhakti
Published: November 2023

Based on their sustainability reports (SR), this study investigates Indonesian stated-owned companies’ compliance with fundamental labour rights and corporate governance (CG). Empirical and content analysis was carried out based on the Global Reporting Initiative (GRI) standard index published by 41 state-owned companies from 12 clusters in Indonesia. The study also compared the disclosure performance of several industrial-sector clusters by measuring each cluster’s total compliance rate. This study also analyses whether the high corporate governance disclosure will lead to a high level of fundamental labour rights reports. Using content analysis and multivariate analysis of WarpPLS, this study finds that companies tend to disclose clearly basic requirements on fundamental labour rights, such as information about new hires and employee turnover and essential information on corporate governance structure and composition (Martin et al., 2016; Sikka, 2008). In contrast, companies tend to hide information about reasonable notice of significant operational changes and critical concerns in companies. Based on the industrial sectors, the company in the energy, oil, and gas cluster have the highest level of compliance concerning corporate governance and labour disclosure. Then, this study also discovers that companies with high compliance levels on corporate governance disclosure tend to inform more in labour rights activities.
A modified laser ablation-isotope ratio mass spectrometry method for in situ analysis of sulfur isotope composition of sulfides
Authors: Dongwei Guo , Fan Changfu , Bin Hu , Li Yanhe , Xiaopei Wu , Pengcheng Sun , Kejun Hou , Qian Wang
Published: November 2023

Rationale: A novel laser ablation-isotope ratio mass
spectrometry (LA-IRMS) method for in situ sulfur isotope analysis
of sulfides has been developed. Instead of the in situ reaction
applied by the traditional laser microprobe, the analyte gas preparation
in this method is separated temporally and spatially from the laser
ablation, resulting in improved precision and accuracy.
Methods: Our LA-IRMS system combines an ultraviolet (UV) LA
system, an elemental analyzer (EA), a custom-built cryogenic
concentration system, a continuous-flow interface and an IRMS. The
sulfide aerosol particles generated from LA were transferred by a helium
carrier gas from the ablation cell into the reaction tube and were
converted into SO . Then SO was
enriched in two cold traps and was finally introduced into the ion
source of an IRMS through a continuous-flow interface. Results:
We measured three synthetic and four natural sulfide reference materials
to test the performance of this method. Precisions of ±0.25-±0.64‰ (1SD,
n=5) for δS values can be obtained at a spot
size of 64~80 μm. Measured values and their known true
values for these sulfur isotope reference materials showed good linear
relationship (R =0.998~0.9995) with
slope of approaching unity (1.0509~1.1313).
Conclusions: Data from the measurement of reference materials
showed that the precision and accuracy of our method was satisfactory.
This method is a powerful tool for in situ sulfur isotope
measurement of sulfides, and can be further applied to in situ
carbon and oxygen isotope analyses.
Combining FAIMS based Glycoproteomics and DIA Proteomics reveals widespread proteome alterations in response to glycosylation occupancy changes in N. gonorrhoeae.
Authors: Hadjineophytou Chris , Loh Edmund , Koomey Michael , Scott Nichollas
Published: November 2023

Protein glycosylation is increasingly recognized as a common protein
modification across bacterial species. Within the Neisseria genus
O-linked protein glycosylation is conserved yet closely related
Neisseria species express O-oligosaccharyltransferases (PglOs) with
distinct targeting activities. Within this work, we explore the
targeting capacity of different PglOs using Field Asymmetric Waveform
Ion Mobility Spectrometry (FAIMS) fractionation and Data-Independent
Acquisition (DIA) to allow the characterization of the impact of changes
in glycosylation on the proteome of N. gonorrhoeae. We demonstrate FAIMS
expands the known glycoproteome of wild type N. gonorrhoeae MS11 and
enables differences in glycosylation to be assessed across strains
expressing different pglO allelic chimeras with unique substrate
targeting activities. Combining glycoproteomic insights with DIA
proteomics, we demonstrate that alterations within pglO alleles have
widespread impacts on the proteome of N. gonorrhoeae. Examination of
peptides known to be targeted by glycosylation using DIA analysis
supports alterations in glycosylation occupancy occurs independently of
changes in protein levels and that the occupancy of glycosylation is
generally low on most glycoproteins. This work thus expands our
understanding of the N. gonorrhoeae glycoproteome and the roles that
pglO allelic variation may play in governing genus-level protein
glycosylation.
Biogeography and niche differentiation of Bathyarchaeia in paddy soils across eastern China
Authors: Yi Xingyun , Brandt Kristian , Xue Shu-Dan , Peng Jingjing , Wang Yifei , Li Meng , Deng Ye , Duan Guilan
Published: November 2023

Bathyarchaeia (formerly Bathyarchaeota) is a group of highly abundant
archaeal communities that play important roles in global biogeochemical
cycling. The presence of Bathyarchaeia in arable soils is relatively
limited. In this study, we aimed to investigate the spatial
distributions and diversity of Bathyarchaeia in paddy soils across
eastern China, which is a major rice production region. The relative
abundance of Bathyarchaeia among total archaea ranged from 3% to 68%,
and Bathy-6 was the dominant subgroup. Bathyarchaeia showed higher
migration ability and wider niche. Soil pH and C/N ratio were identified
as key factors influencing the Bathyarchaeia composition, whereas C/N
ratio and mean annual temperature influenced the relative abundance of
Bathyarchaeia. Network analysis showed that specific Bathyarchaeia taxa
occupied keystone positions in the archaeal community and co-occurred
with some methanogenic and ammonia-oxidizing archaea. This study
provides important insights into the biogeography and niche
differentiation of Bathyarchaeia in agroecosystems.
Bacillus amyloliquefaciens exopolysaccharides promote the defensive and protective functions of intestinal epithelial cells
Authors: Cheng Hsueh-Ling , Sung Wei-Wen , Tseng Chien-Ming , Lee Lin-Lee
Published: November 2023

Bacillus amyloliquefaciens was demonstrated to improve gut
health, ameliorate inflammation, and enhance immunity in animal models,
but underlying mechanisms are unclear. This study investigated the
effects of the exopolysaccharides (EPS) of B. amyloliquefaciens
amy-1 on the intestinal epithelium, further exploring the mechanisms
underlying the probiotic function of B. amyloliquefaciens. The
expression of mucin 1, inducible nitric oxide synthase,
cyclooxygenase-2, interleukine-8, antimicrobial peptides TFF-3,
β-defensin 2, S100A8, S100A9, and RegIII-α were all increased in EPS- or
lipopolysaccharide (LPS)-treated Caco-2 cells, suggesting that EPS
enhanced the defensive abilities of intestinal cells. However, unlike
LPS, EPS did not activate the inhibitor kappa B kinase/tumor necrosis
factor-α (TNF-α) pathway, indicating that EPS did not cause
inflammation. Moreover, EPS enhanced the barrier function of cells; the
underlying mechanism was likely associated with enhanced expression of
tight-junction proteins. EPS activated the nuclear factor erythroid-2
related factor 2/heme oxygenase-1 pathway and decreased the level of
reactive oxygen species, whereas LPS did not, suggesting that EPS
improved the protective functions of the epithelium. Confocal
microscopic images showed EPS binding to cell surfaces and internalizing
into cells, whereas dextran, another microbial exopolysaccharide, did
not. Together, our data suggest that EPS are involved in the probiotic
function of B. amyloliquefaciens.
Cancer awareness and screening practices of Ghanaian adults: a cross- sectional survey
Authors: Akakpo Patrick Kafui , Akakpo Martin Gameli
Published: November 2023

Introduction: Cancer screening has been identified as an important
contributor to cancer prevention and the control of both morbidity and
mortality from cancer. Despite its importance, screening rates have
remained low in Ghana. This study investigated some key predictors of
screening habits and the rates of awareness for selected cancers that
are amenable to screening and early detection. The health belief model
provided theoretical support for the investigation. Methods: Data was
collected from 503 adults in an online survey with a questionnaire,
between June and August 2021. Univariate statistical analysis was used
to determine the frequencies and percentages of variables. The
multivariate analysis used a correlation and a logistic regression to
measure association and test a model. Results: Participants were aged
between 18 and 74 with a mean age of 32.74. Females made up 61.4% of
the sample while males accounted for 38.6%. Only 37.6% of participants
had previously screened for cancer while 62.4% had never screened. The
study hypothesized that age, gender, and cancer Screening Awareness
predict the Cancer Screening habits of respondents. The logistic
regression showed that, Age (B = .10, SE = .01, p= .00) and Gender (B =
-.2.71, SE = .30, p = .00) predicted cancer screening habit. Conclusion:
Age and gender can predict screening habits. Awareness did not predict
screening in this study. The reason and meaning of the findings are
discussed and suggestions for improvement of screening uptake and for
future research are provided.
Continuous QoS-compliant Orchestration in the Cloud-Edge Continuum
Authors: Bisicchia Giuseppe , Forti Stefano , Pimentel Ernesto , Brogi Antonio
Published: November 2023

The problem of managing multi-service applications on top of Cloud-Edge
networks in a QoS-aware manner has been thoroughly studied in recent
years from a decision-making perspective. However, only a few studies
addressed the problem of actively enforcing such decisions while
orchestrating multi-service applications and considering infrastructure
and application variations. In this article, we propose a next-gen
orchestrator prototype based on Docker to achieve the continuous and
QoS-compliant management of multiservice applications on top of
geographically distributed Cloud-Edge resources, in continuity with
CI/CD pipelines and infrastructure monitoring tools. Finally, we assess
our proposal over a geographically distributed testbed across Italy.
Ocena zróżnicowania sytuacji finansowej przedsiębiorstw z branży TSL z wykorzystaniem wielowymiarowej analizy skupień
Authors: Maciąg Agnieszka
Published: November 2023

Głównym celem artykułu było ustalenie podobieństw pomiędzy poszczególnymi segmentami branży TSL z wykorzystaniem wyników finansowych przedsiębiorstw przy uwzględnieniu specyfiki ich działalności, a także wpływu pierwszego roku pandemii COVID-19 na kondycję majątkowo-finansową podmiotów prowadzących działalność w obszarze szeroko rozumianej logistyki. Do przeprowadzenia analiz wykorzystano reprezentatywne dane finansowe obejmujące sektorowe wskaźniki finansowe zgodnie z Polską Klasyfikacją działalności dla przedsiębiorstw działających w następujących branżach: transport lądowy oraz transport rurociągowy (PKD 49), transport wodny (PKD 50), transport lotniczy (PKD 51), magazynowanie i działalność usługowa wspomagająca transport (PKD 52), działalność pocztowa i kurierska (PKD 53). Do eksploracyjnej analizy danych przeprowadzono analizę skupień z grupowaniem metodą k-średnich. Przeprowadzone badania pozwoliły pogrupować przedsiębiorstwa w trzech grupach. Łącznie zidentyfikowano cztery klastry. Podobieństwa pomiędzy grupami odnosiły się do wskaźników płynności, zadłużenia oraz rentowności sprzedaży. Niejednorodne grupy dotyczyły bezpieczeństwa finansowego jednostek w zakresie trwałości struktury finansowania i rentowności posiadanego majątku.
Salivary and crevicular fluid proinflammatory cytokines and advanced glycation end products in patients with different glycemic levels undergoing fixed orthodontic treatment
Authors: Kamran Muhammad Abdullah
Published: November 2023

Objective

To examine whether patients with different blood glycemic levels undergoing fixed orthodontic therapy demonstrate changes in the biochemical profiles of crevicular fluid and salivary advanced glycation end products (AGEs) and proinflammatory cytokine levels in comparison with nondiabetic healthy subjects.

Materials and Methods

Prediabetic subjects, subjects with type 2 diabetes mellitus (T2DM), and subjects without a diabetes mellitus diagnosis undergoing fixed orthodontic therapy with MBT prescription brackets (0.022-inch brackets and 0.019 × 0.025-inch stainless steel archwires) were included in the study. The following clinical periodontal parameters were evaluated: (1) plaque score (PS), (2) probing depth (PD), (3) bleeding on probing (BOP), and (4) clinical attachment loss. Crevicular fluid and saliva specimens were collected during regular orthodontic visits. Salivary and crevicular fluid tumor necrosis factor alpha, interleukin-6, ghrelin, resistin, AGEs, and receptor activator of nuclear factor κΒ ligand were evaluated using a human magnetic Luminex multiplex assay.

Results

BOP scores were significantly higher among T2DM subjects (19.2%) than among nondiabetic subjects (11.2%) and prediabetic subjects (15.9%). Comparable values were demonstrated by all three study groups regarding PD scores and PSs. T2DM subjects demonstrated higher scores for gingival crevicular fluid (GCF) chemokines than nondiabetic and prediabetic subjects. A statistically significant difference was found in the levels of AGEs and resistin among the three study groups. The scores revealed for the levels of GCF resistin and AGEs versus periodontal BOP demonstrated a significant positive association by the Pearson correlation test.

Conclusions

T2DM patients demonstrated significantly higher levels of GCF resistin and AGEs during fixed orthodontic therapy. Chronic hyperglycemic patients undergoing orthodontic therapy demonstrated a proinflammatory response.
Efficacy and safety of mazdutide in Chinese patients with type 2 diabetes: A randomized, double-blind, placebo-controlled phase 2 trial
Authors: Zhang Bo , Cheng Zhifeng , Chen Ji , Zhang Xin , Liu Dexue , Jiang Hongwei , Ma Guoqing , Wang Xiaoyun , Gan Shenglian , Sun Juan , Jin Ping , Yi Jianjun , Shi Bimin , Ma Jianhua , Ye Shandong , Wang Guixia , Ji Linong , Gu Xuejiang , Yu Ting , An Pei , Deng Huan , Li Haoyu , Li Li , Ma Qingyang , Qian Lei , Yang Wenying
Published: November 2023

OBJECTIVE We conducted a randomized, double-blind, placebo-controlled phase 2 trial to evaluate the efficacy and safety of mazdutide, a once-weekly GLP-1 and glucagon receptor dual agonist, in Chinese patients with type 2 diabetes. RESEARCH DESIGN AND METHODS Adults with type 2 diabetes inadequately controlled with diet and exercise alone or with stable metformin (glycated haemoglobin A1c [HbA1c] of 7.0%–10.5% [53–91 mmol/mol]) were randomized to receive mazdutide 3 mg (n = 51), mazdutide 4.5 mg (n = 49), mazdutide 6 mg (n = 49), open-label dulaglutide 1.5 mg (n = 50) or placebo (n = 51) subcutaneously for 20 weeks. The primary outcome was change from baseline to week 20 in HbA1c. RESULTS Mean changes in HbA1c from baseline to week 20 ranged from −1.41% to −1.67% with mazdutide (−1.35% with dulaglutide and 0.03% with placebo) (all p<0.0001 versus placebo). Mean percent changes in body weight from baseline to week 20 were dose-dependent and up to −7.1% with mazdutide (−2.7% with dulaglutide and −1.4% with placebo). At week 20, participants with mazdutide were more likely to achieve HbA1c target of <7.0% (53 mmol/mol) and ≤6.5% (48 mmol/mol), and body weight loss from baseline of ≥5% and ≥10%, compared with placebo-treated. The most common adverse events with mazdutide included diarrhoea (36%), decreased appetite (29%), nausea (23%), vomiting (14%) and hypoglycemia (10%; 8% with placebo). CONCLUSIONS In Chinese patients with type 2 diabetes, mazdutide dosed up to 6 mg was generally safe and demonstrated clinically meaningful HbA1c and body weight reduction. Article Highlights l Despite increasing application of GLP-1 receptor agonists in glycemic control, evidence of co-agonism with glucagon receptor in the treatment of type 2 diabetes remains limited. l Does mazdutide, a once-weekly GLP-1 and glucagon receptor dual agonist, reduce HbA1c and body weight in patients with type 2 diabetes? l In this phase 2 study, 20 weeks’ treatment with mazdutide achieved mean HbA1c reductions up to 1.67% and mean body weight reductions up to 7.1%. The most common adverse events with mazdutide were gastrointestinal in nature. l The results supported future development of mazdutide for the treatment of type 2 diabetes.
Recovery of Zn from Auger Press Briquettes Made from Steelmaking Sludge
Authors: Tkalenko Illia , Kovtun Oleksii , Koriuchev Nikita , Platonov Leonid , Shehovsov Daniel
Published: November 2023

The presence of zinc in metallurgical byproducts poses a constraint on their reutilisation within the realm of ferrous metallurgy. This study delves into the viable prospect of zinc extraction from briquettes manufactured through the auger pressing technique by pyrometallurgical methods. These briquettes are crafted from converter sludge, anthracite, and a multifaceted binding agent. The study encompasses laboratory and industrial trials, spanning the auger pressing technological line, and a tunnel kiln. The consequential outcome of this process yields metallized iron-infused briquettes, effectively purged of zinc content. These briquettes emerge as a propitious raw material option for steelmaking endeavours.
Extension and the Adoption of Commercial Rabbit Production in Hai District
Authors: Rugarabamu Orestes Medard , Kidudu Joshua Samwel , Shausi Gosbert Lukenku
Published: November 2023

Extension is the term, which is open to many interpretations. Every extension personnel have a unique interpretation of extension, based on experience and agent’s field. Generally, there is no single definition of extension, which is accepted worldwide. Briefly, extension is informal educational process directed toward rural community. The process offers information and advice that help rural population to make their decisions and solve their challenges. The main aim is to improve productivity and hence better living standard of farming families. This paper aims to show the relationship between extension and the adoption of commercial rabbit in Hai District as a means of improving livelihood and productivity of rabbit products and by-products. Rabbits are kept for both food and commercial purposes. Commercial rabbit production refers to raising rabbits for income-generation or for business. Commercial rabbit production has numerous advantages that all the products and by-products are of commercial value. For example, rabbit skins are used to make blankets and many items of useful clothing for children and adults, such as shirts, leggings, socks, hoods, purse, and handbags. Rabbit urine and manure are used in manufacturing organic booster and pesticide. Commercial rabbit production has been in Hai District since 2018 as initiated by the Saore Company Limited. Despite its numerous benefits and efforts made by Saore Company Limited to promote commercial rabbit production in the district, only about 0.001 per cent of the population is engaged in commercial rabbit production. Several studies have associated the adoption of innovations with extension. Taking commercialization of rabbit production as an innovation, this study determined the relationship between extension and the adoption of commercial rabbit production in Hai District. The study adopted a survey research design to collect data from 170 respondents (85 commercial and 85 non-commercial rabbit producers) using a questionnaire. Data triangulation was done through key informant interviews. Both descriptive and inferential statistics were used to analyse the data whereby cross tabulation chi-square test of significance was fitted. The study found a significant relationship between extension and the adoption of commercial rabbit production in the study area. It is therefore, concluded that extension was significantly related to the adoption of commercial rabbit in the study area.
Belt and Road Initiatives (BRIs): Understanding China’s Intentions Behind It
Authors: Rabeya Sumaiya
Published: November 2023

BRI is regarded as the most aspiring foreign and economic policy initiative of President Xi’s legacy. At the same time, Beijing has the overarching objective to achieve its geopolitical goals by economically binding China’s neighbouring countries through this initiative. Some Scholars are cynical regarding the success of BRI as planned by President Xi’s administration, urging caution for both China and the countries involved. President Xi’s exceptional overt emphasis on protecting China’s national interests that transpired into their newly formed foreign policy approaches has demonstrated that China’s commitment to peaceful development is not without conditions. China’s commitment to a peaceful rise will also be further conditioned by the many externalities, namely international and regional interest, domestic priorities, security dilemmas, power conflict, and conflicting core national interests from participating members, which in turn can be reciprocated with antagonistic strategies by others. Consequently, President Xi’s administration will have to tackle formidable challenges in the implementation era of BRI.
Tambo Alam Minangkabau : Studi Historiografi Tradisional dalam buku Tatanan Adat Warisan Nenek Moyang Orang Minang Karya Ibrahim Dt Sanggoene Diradjo yang berjudul Peristiwa Batu Batikam
Authors: Alfiansyah Muhammad Fajar , Hardi Etmi
Published: November 2023

This study examines the Tambo Alam Minangkabau: The Customary Order of the Ancestors of the Minangkabau Ancestors by Ibrahim Dt Sanggoene Diradjo regarding the Batu Batikam Event. The purpose of this study is to examine a work in the tambo based on traditional historiography. This research is included in the type of historical qualitative research. Therefore the research, Tambo Alam Minangkabau: Traditional Historiographical Studies in the book Customary Orders Inherited by the Minang People's Ancestors by Ibrahim Dt Sanggoene Diradjo. in the form of articles, books or journals. The first step in this research is to collect books or writings that are relevant to the study. The second step is analysis and interpretation. Then the third step is presenting the findings or research results in the form of a report or historiography
Peranan Perempuan Transmigran Jawa dalam Meningkatkan Ekonomi Keluarga di Nagari Sungai Duo Kecamatan Sitiung Kabupaten Dharmasraya
Authors: Pratama Fajra Adhilo Putrawera , Najmi Najmi
Published: November 2023

Javanese transmigrant women have experienced a paradigm shift towards the division of labor due to economic needs in fulfilling their daily lives. The lack and limitation of their husband's income, the increasing demands of life's needs encourage housewives to take the initiative to be independent and work in the public and domestic sectors. Women are always considered as domestic workers, or homemakers, who do not have the ability to actively contribute outside the home, so their role is limited to activities within the home. This study aims to determine the economy of Javanese transmigrant women in improving the family economy in Nagari Sungai Duo, Sitiung District, Dharmasraya Regency. The research method used is the historical method which consists of topic selection, heuristics, criticism, interpretation, and historiography. The findings show that the role of Javanese transmigrant women in improving the family economy in Nagari Sungai Duo is that there are three main activities that are generally carried out by the Javanese transmigrant women, such as women farming groups, farming laborers, and raising cattle. Based on the findings, it can be concluded that Javanese transmigrant women are able to play a role in meeting the economic needs of their families as additional income from their husbands.
Ibrahim : Dari Penjual Kopra Sampai Menjadi Pengusaha Industri Minyak kelapa Di Nagari Lareh Nan Panjang Barat, Kecamatan VII Koto Sungai Sarik, Kabupaten Padang Pariaman (1965-2000)
Authors: Khairi Syabikul , Naldi Hendra
Published: November 2023

Penelitian ini membahas tentang biografi Ibrahim (Sibaduik), seorang pengusaha Industri Minyak Kelapa Kopra asal Lareh Nan Panjang, Kecamatan VII Koto Sungai Sarik. Penelitian ini bertujuan untuk mengetahui perjalanan karir Baduik sebagai pengusaha Industri Minyak Kopra dan dampaknya terhadap kehidupan masyarakat sekitar. Penelitian ini menggunakan metode penelitian sejarah dengan empat tahap. Tahap pertama heuristik (mengumpulkan data), tahap kedua kritik sumber (menguji keaslian informasi), tahap ketiga adalah interpretasi (menafsirkan data), dan tahap keempat adalah historiografi (tulisan). Hasil penelitian ini menjelaskan bahwa perjalanan karir Sibaduik dimulai dari menjadi seorang pembeli kelapa dan kopra dengan Bakonya di Limau Puruik selama dua tahun hingga akhirnya sukses mendirikan pabrik industri minyak kopra  sendiri di rumah. Tak hanya sukses mendirikan pabrik industri minyak kopra, Sibaduik juga memanfaatkan limbah olahan minyak kopra untuk dijadikan sabun. Adanya pabrik Baduik memberikan dampak positif bagi kehidupan masyarakat sekitar dengan memberikan lapangan pekerjaan.
Escenario legal de la pensión de alimentos en el Perú, una mirada desde la posición del alimentista
Authors: Riveros Tolentino Edy Leonardo
Published: November 2023

El presente artículo científico tuvo como objetivo analizar desde el aspecto jurídico cuál es el escenario legal de la pensión de alimentos en el Perú desde la posición del alimentista. El método que se utilizó fue el enfoque cualitativo; tipo de estudio, básica y diseño de investigación, la teoría fundamentada.Se aplicaron las técnicas de la entrevista y el análisis documental con sus respectivos instrumentos: la guía de entrevista y el documento. Se tuvo como participantes a 8 operadores de justicia (4 abogados, 3 fiscales provinciales penales y un juez de familia), a quienes se les aplicó la guía de entrevista, lamisma que estuvo compuesta por 6 preguntas relacionadas al tema principal. Los resultados de esta investigación fueron las siguientes: primero, existe unafalta de regulación normativa, (los artículos del código civil que van del 472 al 487, no terminan favoreciendo al alimentista). Segundo, los devengados producto de la otorgación del auto admisorio no son reembolsables. La dilación del tiempo en cuanto a la otorgación de la pensión de alimentos. Esto lo vemos en los procesos de alimentos que varios de ellos van más allá de los 5 años, tiempo que el alimentista no recibe su pensión de alimentos y finalmente, la falsa representación tutorial, esto se manifiesta cuando los padres no demandan cuando deben hacerlo. Por lo tanto, se concluye que el escenario legal de la pensión de alimentos en el Perú desde la posición del alimentista es desfavorable.
About the contributers
Authors: Hanlon Robert
Published: November 2023

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Chemical reactor stability research of ethylene polymerization
Authors: Istomin Andrey Leonidovich , Stupina Alena Aleksandrovna , Krivov Maksim Viktorovich , Istomina Alena Andreevna , Golovkova Elena Aleksandrovna
Published: November 2023

The chemical reactor is the main and most complex object in the management of the technological process of polymerization. When designing chemical reactors, it is necessary to select design and operating parameters that will be able to provide the only or most stable state with the specified process characteristics. To study the stability of the ethylene polymerization process in an autoclave reactor with a stirrer, it is necessary to build a mathematical model based on the analysis of the physico-chemical laws of the process and search for the necessary steady-state conditions for the reactor. A solution based on a deterministic mathematical model of ethylene polymerization is proposed. The description of the process of polymer molecule formation, which includes the stages of initiation, growth and chain breakage; the mechanism of chemical kinetics of ethylene polymerization; a system of assumptions to simplify the construction of a mathematical model. The mathematical model of an ethylene polymerization reactor in an autoclave reactor with a stirrer is a system of differential equations. When calculating the static reactor mode, the mathematical description contains a system of nonlinear algebraic equations, the solution of which is implemented using numerical methods. It is noted that chemical reactors can have not one, but several stationary states at the same values of variables and parameters. Knowing the coordinates of the stationary states of the chemical process, you can choose the one that is more preferable from the point of view of productivity or the quality of the products produced. As a result of the simulation, the existence of a single solution under the conditions found that ensure a stable stationary state of the chemical ethylene polymerization reactor is confirmed.
Additional boundary conditions in thermal conductivity problems with heterogeneous boundary conditions
Authors: Trubitsyn Konstantin Viktorovich , Kotova Evgeniya Valerievna , Gavrilova Tat'yana Evgen'evna , Kolotilkina Kseniya Vladimirovna , Zaitsev Sergey Vladimirovich , Tarabrina Tamara Borisovna
Published: November 2023

Using additional boundary conditions (ABC) and an additional sought function (ASF), a solution to the heat conduction problem with non-homogeneous boundary conditions has been obtained. ABC allows satisfying the differential equation at the boundaries, leading to its fulfillment both inside the domain and without resorting to integration over Cartesian coordinates. ASF reduces the original partial differential equation to a temporal ordinary equation, from which the eigenvalues of the boundary value problem are determined, as formulated in the classical methods of the Sturm-Liouville problem, stated in spatial variables. Thus, this work considers an alternative way of determining eigenvalues. The integration constants are found from the initial condition using the least squares method, which allows their values to be determined with a given accuracy. The solution obtained based on ABC and ASF approximates n → ∞ the exact analytical solution in the form of an infinite series, including trigonometric coordinate functions with coefficients that stabilize exponentially in time. In this case, the eigenvalues determined from the solution of the temporal ordinary differential equation regarding the additional sought function coincide with their exact values at any approximation. The accuracy of the integration constants, determined by the method of least squares, is controlled by the number of approximation points in the range of the auxiliary variable's variation. It should be noted that the additional boundary conditions considered in this work hold true for any other method of obtaining a solution to the problem under consideration, including the exact method, as can be verified by direct substitution. Therefore, their introduction does not distort the original mathematical formulation of the problem but only significantly simplifies the process of obtaining its analytical solution.
Uji Sifat Fisik Sediaan Lulur Ekstrak Bayam Merah (Amaranthus tricolor L.) Serta Uji Efektivitas Kelembaban (Moisture) Dan Kehalusan (Evenness) Pada Kulit
Authors: Iskandar Benni , Tarigan Jacub , Leny Leny , Hanum Widia
Published: November 2023

Sediaan lulur atau“body scrub” merupakan salah satu dari banyaknya sediaan kosmetik, lulur tersendiri berfungsi membuang ataupun mengangkat sel mati. Bayam merah (Amaranthus tricolor L.) adalah tanaman ataupun lebih tepatnya jenis sayuran yang biasa dikonsumsi sehari-hari yang bisa dimanfaatkan sebagai bahan baku dari sediaan lulur karena tingginya kandungan antosianin. Antosianin pada bayam merah bermanfaat sebagai antioksidan yang mampu menghambat radikal bebas. Bayam merah juga kaya akan kandungan vitamin A, Vitamin C, protein, kalsium, dan lainnya. Adapun tujuan dari studi ini adalah untuk mengetahui bayam merah yang dapat diformulasikan menjadi sediaan lulur atau body scrub yang memiliki karakteristik yang stabil dan mampu memperbaiki, meningkatkan kadar air pada kulit serta kehalusan pada kulit. Proses dan metode studi ini dengan mengekstraksi daun bayam merah (Amaranthus tricolor L.) dengan maserasi, kemudian formulasi sediaan lulur dibuat dengan beberapa variasi konsentrasi yaitu 0,5%, 1% dan 1,5%. Pengujian sediaan meliputi organoleptis, homogenitas, pH, daya sebar, iritasi, uji stabilitas, uji efektivitas kelembaban dan kehalusan dengan menggunakan instrumen skin analyzer pada kulit sukarelawan. Hasil studi yang dibuktikan dengan membandingkan hasil sebelum dan setelah cycling test menunjukan bahwa sedian lulur dari masing-masing formula memenuhi persyaratan organoleptis, homogenitas, pH lulur 5,7-5,9 (persyaratan pH sediaan ke kulit yaitu 4,5-6,5), daya sebar 5,3-5,6 (persyaratan 5-7 cm), tidak mengiritasi kulit, serta uji efektivitas kelembaban (moisture) dan kehalusan (evenness) pada kulit sukarelawan menunjukkan hasil analisis studi yang signifikan (p ≤ 0,05) pada F1, F2, F3 dan tidak menunjukkan hasil analisis yang signifikan (p ≥ 0,05) pada F0. Kesimpulan yang dapat diambil dari studi ini bahwa ekstrak daun bayam merah (Amaranthus tricolor L.) dapat diformulasikan serta memenuhi persyaratan uji sifat fisik sediaan lulur atau body scrub, tidak menyebabkan iritasi pada kulit, serta dapat memberikan kenaikan nilai persentase efek yang melembabkan kulit dan menghaluskan kulit dengan menggunakan skin analyzer.