bluuebunny/crossref_metadata_2025 huggingface dataset:
PREVENTION OF CRIMES COMMITTED IN THE DIGITAL URRENCY (CRYPTOCURRENCY) TURNOVER
Authors: ПИНКЕВИЧ Татьяна Валентиновна
Published: January 2022

In modern Russia, thanks to the development of digital technologies, the usual image of economic relations is radically changing. The list of possibilities of their application in the modern world is rapidly expanding. The construction of a digital economy system as the most optimal environment for the application of these technologies is the logical outcome of digital transformation. Against this background, virtual economic relations, electronic payment services, virtual crypto exchanges, crowdfunding are actively developing, which contributes to the development of electronic money and digital currencies. These processes have increased the number of criminal manifestations, crime has been modernized, new types of crime have appeared, as well as new objects, methods and means of committing crimes. The results of the author’s comprehensive crime study indicate an increase in crimes committed using digital currency (cryptocurrency) [1, p. 89; 2, p. 287]. In this connection, consideration of the problems of its conceptual apparatus, legal regulation, study of the issues of legalization of this digital asset, criminal activities with its use may be now necessary to ensure criminological security, since national authorities do not control digital currency (cryptocurrency); it can compete with national fiat currencies and lead to their weakening. At the same time, the development of the digital currency (cryptocurrency) market and the growth of transactions is increasing daily. Sometimes they are used for criminal purposes. However, the insufficiency of its regulation is not conducive to the prevention of crimes in which it is the means of commission and the object of criminal activity. The purpose of the article is to develop scientifically sound proposals for improving criminal legislation and preventing crimes committed both in relation to digital currency (cryptocurrency) and with their use. Methods. In the course of the study, general scientific methods of cognition are used, as well as special scientific methods (system-structural, formal-logical extrapolations, prognostic, documentary analysis, statistical, interviewing, etc.). The results of the study show a high level of acts committed both in relation to the digital currency and with its use. Such crimes are characterized by a high degree of public danger, determined by the damage caused to the individual, society and the state, as well as the commission of acts by representatives of transnational organized crime, characteristics of the object and means of committing such crimes, social consequences, and a high level of latency. The relevance and expediency of criminalization of these crimes is proved, as evidenced by crime statistics, materials of judicial practice, the nature and degree of their public danger, and the possibility of influencing them by legal means. Proposals have been prepared and presented to improve criminal legislation in the field of preventing crimes committed using digital currency (cryptocurrency).
COUNTERACTING FORBIDDEN ADVERTISING OF ONLINE SALE OF DRUGS
Authors: ФИЛЬЧЕНКО Андрей Петрович , ЖАНДРОВ Владимир Юрьевич
Published: January 2022

In view of the increase in drug trafficking offences committed through the use of information and telecommunications technologies, the state must seek effective ways to reduce the drug market. Counteracting illegal advertising of drugs and their marketing addresses on the Internet (Darknet) is a promising area of prevention that has been underestimated to date. The purpose of the article is to determine the main directions of Russia’s criminal policy in the field of counteracting open and veiled advertising of online stores selling drugs in a non-contact manner. Methods of statistics, content analysis of Internet resources, systemic, formal-logical and legal analysis are used. Results: illegal advertising in the area of drug trafficking is an independent direction of professional criminal activity, using marketing techniques tested in the legal economy. The advertisement of online drug stores on urban infrastructure facilities, regular websites and social media helps to expand the reach of drug users. Efforts to combat illicit drug advertising, including the criminalization of such advertising, should be part of Russia’s criminal policy.
UNIQUE AND NATURALLY DETERMINED ATTRIBUTES OF THE MODERN UNDERSTANDING OF A STATE
Authors: КАЛИНИН Сергей Артурович
Published: January 2022

The article analyzes the issues of the modern understanding of a state, as well as the factors and determinants that define its essence. The idea is put forward that the most important factor determining the necessity to rethink the essence of the state is the modern global crisis and chaotic instability. A methodology for research of the state is proposed that meets post-non-classical scientific and managerial rationality. The article substantiates a new European nature and attributes of modern statehood, which is also influenced by the three-level structure of statehood in the world system, as well as the peculiarities of the historical genesis of specific countries. The author proposes researching of the state through the correlation of the triad of parameters «power – population – territory», the interaction of which generates various types of power organization. Purpose: to propose new methods suitable for studying the state in the context of the current global crisis, accompanied by a decrease in the heuristic and cognitive potential of the methodology formed within the framework of liberal geoculture; to analyze the essence and nature of modern statehood on the basis of the proposed methods. The author uses the following methods: post-non-classical scientific paradigm, the principle of the observer's involvement in the cognizable reality, world-system analysis, subjective approach, spatial dimension, historical approach. Results: the research reveals a new European nature of modern statehood, which is declining as a result of the global crisis, and historical features of the formation of this type of statehood, in relation to the Republic of Belarus in particular.
Study of Etiological Pattern of Acute Meningo-Encephalitis Syndrome
Authors: Uddin Mohammad Najim , Uddin Hassan Md Mahtab
Published: January 2022

Background: Acute meningo-encephalitis syndrome is a medical emergency which claim urgent management. So the objectives of the present study was to find out aetiological factors and differentiating parameter between different types acute meningoencephalitis syndrome with minimum investigation.
Methods: This hospital based observational study was carried out in medicine units of Chittagong Medical College. Fifty cases were studied who present with acute onset fever with central nervous system dysfunction.
Results: In this study it reveals that hospital rate of bacterial meningitis was 26%, viral encephalitis was 34% and severe malaria was 26% among the patient with acute meningo-encephalitis syndrome. It shows that mean age (years) in viral encephalitis was 33.71, bacterial meningitis was 34.15 & in severe malaria was 27.92. It reveals that all patients of this series presented with acute onset fever (n=50,100%), maximum patients present with sign of meningeal irritation (n=44, 88%) & altered mental state (n=41,82%). Few patients was present with new onset seizure (n=11,22%) & neurologic deficit (n=1,2%). In Bacterial meningitis most patient was with low CSF glucose (n=10, 76.9%). In viral meningitis there were normal CSF glucose level (n=17,100%). High protein content in bacterial (n=13,100%) & Viral (n=15,88.2%) was found. It shows differential count of CSF WBC in different type of meningitis where in Bacterial meningitis it is neutrophils & in other type of meningitis it is the lymphocyte.
Conclusion: CSF findings are hallmark of diagnosing various type of meningitis. CSF glucose and protein content found in this study significantly correlate with different etiology (p value = 0.000).
Bangladesh Journal of Neuroscience 2018; Vol. 34 (1): 45-51
Driving Forces of Landuse and Landcover Changes in the North-eastern Part of Dhaka Conurbation
Authors: Sajib Abdul Majed , Moniruzzaman Md
Published: January 2022

The study identifies decadal landuse and landcover (LULC) changes during 1988-2017 in north-eastern Dhaka conurbation of Bangladesh. Driving forces behind the changes in the study area have also been investigated.In this study, LULC changes were studied using two Landsat sensors. GIS post-processing technique was used for satellite image classification, while an in-depth literature review was conducted to identify the drivers of land cover change. Accuracy for the classified maps ranged from 79percent to 86percent. It was found that agricultural land decreased 47.02 percent while homestead vegetation land cover has increased about 88 percent in the last thirty years (1988-2017).The in-depth analysis result indicates that Dhaka metropolitan area expansion, increased population, internal migration, ongoing housing development projects, and lack of proper landuse and land management implementation are the main drivers of LULC changes in the study area. The development control approach needs to be incorporated into the on-going development projects and activities in the eastern region of greater Dhaka to maintain ecological balance and a green environment of the region.
The Dhaka University Journal of Earth and Environmental Sciences, Vol. 10(2), 2021, P 53-66
Pandemic and the Emerging Threshold of Disaster Law in South Asia
Authors: Singh Amita
Published: January 2022

Abstract not available
Dhaka University Law Journal, Vol. 32(1), 2021 P.152-173
Conselho tutelar e política eleitoral: a formação da carreira política partidária a partir da função de conselheiro tutelar
Authors: Santos Antônio Nacílio Sousa dos
Published: January 2022

O artigo versa sobre a formação da carreira política partidária a partir do exercício da função pública de conselheiro tutelar. Esse apanhado analítico foi inscrito a partir de dois estudos de caso, ocorrido no Conselho Tutelar (CT) do município de Horizonte, Estado do Ceará. Em tese, esse espaço social – Conselho Tutelar – cria “pontes” para a carreira política partidária, permitindo que outsiders ganhem visibilidade pública que, sem esse recurso, não seria possível adentrar o espaço político partidário. Assim, para essa reflexão, trouxemos as trajetórias de dois cidadãos ditos “comuns” pela sociedade civil, que adentrou o espaço tutelar e a partir daí galgou sua carreira política partidária trabalhando os elementos contidos no campo tutelar. A observação direta e as entrevistas foram às metodologias utilizadas para o apanhado empírico. O artigo conclui que, através de táticas colocadas em prática por qualquer cidadão que adentre o espaço tutelar, da maneira como esse espaço institucional está desenhado, favorece a formação das carreiras políticas partidárias.
Mulheres e a questão racial da sífilis no Brasil: uma análise de tendência (2010-2019)
Authors: Machado Michael Ferreira , França Bruna Stefany Rebouça , Farias Maria Lua Santos Alves de , Costa Mariana Ivo
Published: January 2022

Este estudo objetivou analisar a relação entre a ocorrência de sífilis e a população feminina negra nas cinco regiões geográficas brasileiras e no Brasil entre 2010-2019. Trata-se de um estudo observacional ecológico que utilizou dados secundários disponibilizados pelo Instituto Brasileiro de Geografia e Estatística e pelo Departamento de Doenças Crônicas e Infecções Sexualmente Transmissíveis do Ministério da Saúde. No tratamento estatístico dos dados, foi utilizado o software Jointpoint Regression Program, versão 3.3.1, para analisar as tendências no recorte temporal estabelecido. Os resultados apontam que, apesar de as mulheres pretas e pardas representarem quase metade da população feminina brasileira, estas não possuem o mesmo acesso à saúde que mulheres brancas. Tal fato gera iniquidades que, associadas à discriminação racial, trazem consequências permanentes para saúde de indivíduos e coletividades; e contribuem para a adoção de comportamentos inadequados e para o adoecimento, aumentando a possibilidade de ocorrência de casos de doenças infecciosas, como a sífilis. A essa problemática, soma-se inconformidades nos registros sobre autodeclaração racial de saúde. Assim, o adequado preenchimento das fichas de notificação, bem como a elaboração e execução de políticas públicas voltadas à geração de equidade na saúde podem contribuir para atenuação e enfrentamento da sífilis na população negra.
Burnout in oral and maxillofacial surgeons in Brazilian population during the COVID-19 pandemic: a critical analysis
Authors: Borges Marcela Maria Costa , Aguiar Andréa Silvia Walter de , Alves Natalia Fernandes Teixeira , Mendonça Diego Santiago de
Published: January 2022

The training and activities of an oral and maxillofacial surgeon, although stimulating, motivating, and satisfactory, are not exempt from technical and psychological challenges. Residency training programs aim to develop necessary skills of resistance and rational decision-making under pressure in clinical, outpatient, and complex hospital interventions. Furthermore, these programs also require the fulfillment of activities outside the operating room, such as issuing diagnoses and planning high complexity procedures with a high risk of complications. The aim of this study was to evaluate the levels of burnout in attending surgeons and residents from oral and to maxillofacial surgery residency programs located in the State of Ceará, Brazil, during the SARS CoV-2 (COVID-19) disease pandemic. This observational, cross-sectional study with a quantitative approach was conducted on attending surgeons and residents registered at the Regional Council of Dentistry – Ceará Section. Data were obtained through an online questionnaire with three sets of questions: 1) professional factors; 2) the Oldenburg Burnout Inventory instrument; and 3) sociodemographic aspects. Quantitative data were analyzed with the Statistical Package for Social Science software. Nonparametric statistical analysis (Fisher and Kruskal-Wallis Exact tests) was used, in addition to the Chi-square test, adopting a significance level of 5%. A sample of 78 participants was obtained, in which most attendings (58.7%) and residents (40%) demonstrated moderate levels of burnout. We can conclude that the levels of burnout in oral and maxillofacial attending surgeons and residents from the State of Ceará during the COVID-19 pandemic were moderate, not resulting in high levels of emotional exhaustion and depersonalization.
Entre artes e saberes: sinos que encantam a cidade da fé
Authors: Colares Getuliana Sousa , Castro Jonas Neri de , Colares Maria Ivaneidiane Souza , Nunes Ana Karolina Colares , Santos Adriana Souza Colares , Santos Fábio Costa , Colares Antonia Jeruziana Souza , Andrade Wendel Melo
Published: January 2022

Este artigo apresenta um estudo sobre a trajetória de vida, saberes e artes, de Getúlio Colares Pereira, um cidadão que trabalhou com amor e dedicação como sineiro da Basílica de São Francisco das Chagas de Canindé-Ceará. Realizamos esta pesquisa de cunho bibliográfico tendo como fontes livros, artigos e documentos legais. O objetivo deste trabalho é estudar como foi a história de vida de Getúlio Colares Pereira, os seus ensinamentos e a arte desenvolvida nas badaladas do sino. Buscamos identificar os saberes que este sineiro proporcionou, mostrando suas conquistas e seus caminhos percorridos até alcançar o título de Tesouro Vivo e posteriormente o diploma de Mestre da Cultura pela Universidade Federal do Ceará (UFC). Concluímos através desta pesquisa que o conhecimento de mundo aliado a uma vida inteira de trabalho pode mudar a história de um ser humano. A cultura e os saberes deste Mestre da Cultura vêm cada vez mais sendo valorizada pelos estudiosos e pesquisadores. O Mestre da Cultura Popular Getúlio Colares Pereira, educou pelo exemplo, pelo amor ao que fez, pela fé, pela alegria com o que fez, pela persistência em fazer compartilhar o que sabe com os que se deixam cativar e, assim, os seus alunos aprendem tornando o tocar do sino uma cultura continua para as novas gerações.
Avaliação de correlação entre incidência, internação e mortalidade por COVID-19 com o índice de Desenvolvimento Humano Municipal-IDHM em uma macrorregião de saúde de Minas Gerais
Authors: Ferreira Júnior Cláudio Luiz , Cruz Cleya da Silva Santana , Jesus Kesley Duarte de , Carvalho Carolina di Pietro , Neves Kelly da Rocha
Published: January 2022

A incidência da COVID-19 aconteceu de forma heterogênea em países, estados e municípios, dado as peculiaridades de cada nação, bem como as respostas de seus serviços de saúde em âmbito regional e local. O objetivo desse trabalho foi verificar a correlação entre o Índice de Desenvolvimento Humano Municipal (IDHM) e seus subíndices (renda, educação e longevidade) e as taxas de incidência, mortalidade e internação em uma macrorregião de saúde com 31 municípios. Os dados foram extraídos de bancos de dados online abertos, disponibilizados pelo Ministério da Saúde do Brasil e Secretaria de Estado de Saúde de Minas Gerais (SES-MG). Após aplicação de teste de normalidade sobre as taxas e IDHM, foi realizado teste de correlação de Spearman, a um nível de signficância de 5%. Observou-se correlação positiva, moderada e significativa entre IDH/IDH renda com taxa de incidência e taxa de mortalidade, evidenciando que o aumento de IDH foi associado a incidência de COVID-19 e também mortalidade. A hipótese principal formulada foi que municípios com maiores IDH podem favorecer uma maior circulação de pessoas, bens e serviços, que impactam diretamente na dinâmica de disseminação do vírus. Espera-se que mais trabalhos possam ser realizados visando buscar correlação entre indicadores socioeconômicos, incidência e mortalidade da COVID-19, fortalecendo e direcionando os processos de vigilância nos vários níveis de saúde.
A importância das tecnologias digitais assistivas aliadas do trabalho do professor de língua inglesa com alunos públicos-alvo da educação especial
Authors: Frasson Simone Carloto , Bortoluzzi Valeria Iensen , Ghisleni Tais Steffenello
Published: January 2022

O presente trabalho tem, como objetivo principal, apresentar uma reflexão sobre o uso de Tecnologias Assistivas (TA) enquanto uma ferramenta de apoio ao trabalho do professor de língua inglesa que possui, em sua sala de aula, alunos públicos-alvo da Educação Especial. Em vista disso, foi realizada uma análise das Tecnologias Assistivas utilizadas pelos professores dessa área, bem como foi feito um levantamento das tecnologias que estão disponíveis para contribuir no trabalho do professor de língua inglesa com alunos público-alvo da Educação Especial. A metodologia do presente trabalho, por sua vez, foi fundamentada a partir da abordagem qualitativa e se pautou em estudos de referenciais teóricos de autores como a Martha Gabriel, entre outros. Diante disso, a investigação possibilitou conhecer o cenário das pesquisas sobre as Tecnologias Assistivas e os resultados positivos do uso dessa tecnologia no que se refere à melhora da qualidade de vida dos alunos com necessidades especiais, ou seja, alunos públicos alvos da Educação Especial.
Análise não linear de blocos de concreto armado sobre estacas como fundação de aerogerador onshore considerando o atrito lateral entre as estacas e o solo
Authors: Dantas Diego Lima , Maciel Daniel Nelson , Nascimento Neto Joel Araújo do , Araújo Kaique Yuri Márcio , Barros Rodrigo
Published: January 2022

Na busca por fontes alternativas para atender à crescente demanda por energia, a produção eólica tem tido destaque devido ao grande potencial para sua utilização no Brasil. Dada a magnitude das fundações de unidades aerogeradoras, a compreensão do seu comportamento estrutural é essencial para a concepção de soluções otimizadas, que reduzam custos e facilitem a implantação desta tecnologia em larga escala. Sob esta óptica, este artigo busca aprofundar os estudos acerca do comportamento estrutural de fundações para aerogeradores onshore, representadas por blocos de concreto armado sobre estacas. Foram desenvolvidos modelos computacionais, via Método dos Elementos Finitos (MEF) com o auxílio do software Ansys Workbench R20, considerando-se a contribuição do atrito lateral do fuste das estacas na condução de cargas ao solo, bem como o recalque das estacas, mediante modelagem numérica não linear. Foram dimensionadas as armaduras de uma fundação de torre eólica e propostas duas organizações distintas de malha: circular (AC) e ortogonal (AO). A partir das simulações realizadas, comparou-se, em diferentes tipos de solo, a distribuição das reações nas estacas e os deslocamentos verticais dos blocos. Observou-se que os modelos armados apresentaram um comportamento próximo ao de blocos rígidos, com uma tendência de uniformização das reações e dos deslocamentos verticais. Ao final, foram determinadas as zonas de fissuração do concreto e verificadas as tensões nas armaduras. Os resultados mostraram que as maiores tensões se deram nos modelos com armadura circular (AC), superiores, em média, 2,06% aos modelos AO. Tal tendência foi associada ao fato dos modelos AO terem se mostrado mais rígidos que os modelos AC que, sendo mais deformáveis, impõem às armaduras maiores tensões quando fletidos pelo momento de grande magnitude que atua na fundação.
Aplicações científicas e tecnológicas da derivada e integral usando simulação computacional
Authors: Nóbrega José Cândido da Silva , Silva Stephane Katherine Barbosa Moura da , Santos Romário da Silva , Sousa Glaucio de Meneses , Vieira Camilla Maria da Silva , Souza Athos Cardoso Pereira de , Albuquerque Tiago da Nóbrega , Nascimento José Jefferson da Silva
Published: January 2022

A humanidade passa por uma movimentação tecnológica nunca vista até o momento, em que a informação e a comunicação alcançam um plano essencial na vida das pessoas. Dentre as inovações tecnológicas, destaca-se as simulações computacionais, no qual pode ser conceituada como a construção e manipulação operacional de um modelo, ou seja, uma representação física ou simbólica de aspectos de um processo físico e ou social. As simulações são compostas de um arranjo de diversos esquemas numéricos dedicados a resolver problemas específicos como, por exemplo: resolver equações algébricas, resolver sistemas de equações lineares, interpolar e ajustar pontos, calcular derivadas e integrais, resolver equações diferenciais ordinárias, ou até mesmo problemas reais. Neste contexto, a presente pesquisa tem como objetivo realizar uma revisão bibliográfica sobre aplicações científicas e tecnológicas da derivada e integral usando simulação computacional, a partir de um estudo de caráter exploratório e bibliográfico. Verificou-se que o objetivo do trabalho foi cumprido, tendo em vista que foi apresentado quatro estudos que verificaram diversas aplicações, tais como: fluxos tridimensionais, escoamento superficial, interferência ondulatória, problemas de Finanças, Engenharia e Estatística.
Caracterização da vivência familiar de crianças e adolescentes portadores de Diabetes mellitus tipo 1: uma revisão narrativa
Authors: Souza Maristela Meire Conceição , Alves Thaisy Cristina Honorato Santos
Published: January 2022

O Diabetes Mellitus (DM) é uma condição crônica de saúde caracterizada por hiperglicemia decorrente da impossibilidade de produção ou deficiência na secreção ou ação da insulina. O DM tipo 1 é o mais frequente em crianças e adolescentes. Este estudo tem como objetivo investigar características da vivência familiar após o diagnóstico de diabetes Mellitus tipo 1 em crianças e adolescentes e as possíveis dificuldades encontradas após esse período. Trata-se de uma revisão narrativa, com busca de trabalhos nas bases de dados Literatura Latino Americana e do Caribe em Ciências da Saúde (Lilacs), Pubmed/ Medline, Scientific Eletronic Library Online (Scielo) e Cochrane com estudos publicados nos últimos 20 anos. É evidenciado pelos estudos que a descoberta da doença causa impacto na rotina e alterações no estilo de vida familiar, mostrando-se como principais dificuldades a aplicação de insulina e as adequações alimentares propostas, acrescida de sentimentos como culpa, medo, ansiedade e frustração. Nessas circunstâncias, o apoio dos responsáveis mostra-se fundamental para aceitação e controle da doença pela criança ou adolescente. As modificações evidenciadas podem ocasionar alterações psicológicas e emocionais, bem como no bem-estar e no curso adequado da doença, sugerindo assim a necessidade de apoio e orientações com foco na melhoria da qualidade de vida das crianças e adolescentes e seus familiares.
Dímero D e infarto do miocárdio em pacientes com COVID-19: uma revisão sistemática e meta-análise
Authors: Cardoso Andressa Nogueira , Oliveira Denis Francisco Gonçalves de , Moita Sued Magalhães , Reis Ivna Leite , Assunção Karinne da Silva , Gomes Ana Paula Peres Martins , Feitosa Sthefane Gomes
Published: January 2022

O presente estudo buscou identificar a evidência atual sobre a associação entre níveis de dímero D e a ocorrência de infarto do miocárdio (IM) em pacientes com COVID-19. Para isso, foi realizada uma revisão sistemática, utilizando as seguintes bases de dados: PubMed, Embase, Web of Science, Scopus, Livivo, e Google Scholar. Os critérios de inclusão adotados foram: estudos que investigaram a associação entre COVID-19 e IM; e que apresentaram dados de dímero D. Foram excluídos: estudos de revisão, com modelos animais, in vitro, e relatos de casos. Para a síntese dos resultados, utilizaram-se meta-análises para diferença média padronizada (DMP) referente aos níveis de dímero D. Dessa forma, foram incluídos 6 estudos nesta revisão sistemática apresentando duas abordagens metodológicas: 2 estudos investigaram casos de COVID-19 buscando identificar o desenvolvimento de infarto do miocárdio; e os outros 4 estudos avaliaram pacientes com infarto do miocárdio com o propósito de determinar aqueles pacientes que haviam apresentado COVID-19. Os resultados da DMP nas meta-análises para cada abordagem foram respectivamente: 0,86 [IC95% (0,63 a 1,08), p < 0,0001, favorecendo o grupo que desenvolveu IM] e 2,08 [IC95% (-0,01 a 4,17), p=0,0512, favorecendo quem havia apresentado COVID-19]. Por conseguinte, nesta revisão sistemática demonstramos que existe associação entre os níveis de dímero D em pacientes com COVID-19 e infarto do miocárdio. No entanto, esses resultados apresentaram evidência muito baixa na classificação GRADE, o que aponta a necessidade de mais estudos acerca da temática.
Interações medicamentosas com anti-hipertensivos
Authors: Morais Katiucce Borges de , Dantas Luciana Arantes , Triches Celiana Maria Ferrarini , Porfiro Cínthia Alves , Neto Filho Manoel Aguiar , Santos Jacqueline Silva Guimarães dos
Published: January 2022

A interação medicamentosa (IM) ocorre principalmente devido automedicação, polifarmácia ou erros de prescrição. Indivíduos hipertensos geralmente necessitam mais de um medicamento no tratamento, aumentando a probabilidade de possíveis IM proporcionais a quantidade de medicamentos utilizados, podendo levar a diferentes consequências como alterações no efeito farmacológico, reações adversas, toxicidade acumulativa, comorbidades ou morte. A classe terapêutica anti-hipertensivos, que se subdivide em diversas classes farmacológicas com o mesmo uso terapêutico, é a classe que mais se destaca em IM e fármacos anti-hipertensivos de classes farmacológicas diferentes podem interagir entre si e com outras classes de medicamentos em geral. Assim, o objetivo deste trabalho foi analisar estatisticamente as principais classes farmacológicas e os principais fármacos relacionados a IM com anti-hipertensivos por meio de uma revisão sistemática de literatura selecionando trabalhos publicados nos últimos vinte anos. As interações medicamentosas foram avaliadas segundo a gravidade, classificadas em leves, moderadas e graves. As classes farmacológicas causadoras de IM com anti-hipertensivos mais frequentes foram os hipoglicemiantes, anti-inflamatórios não esteroides (AINES), diuréticos e combinação de dois tipos diferentes de anti-hipertensivos. Já os fármacos anti-hipertensivos que se destacaram em IM foram captopril, enalapril, hidroclorotiazida, propranolol, atenolol, anlodipino, amiodarona, losartana, espironolactona e furosemida.  Portanto, os profissionais da área da saúde precisam se atentar para reações adversas oriundas dessas potenciais IM, notificar e intervir quando necessário para melhorar a eficiência do tratamento farmacológico evitando prejuízos à saúde.
A História do TDAH - Evolução
Authors: Carvalho Aline dos Santos Moreira de , Ferreira Liliane Musumeci , Albuquerque Léia Flauzina da Silva , Jagobucci Lucélia Aparecida , Souza Karla de Lourdes Antunes , Triches Jean Carlos , Almeida Luciana Menezes de , Pereira Ingrid dos Santos , Pereira Erika dos Santos , Souto Pacifico Ferraz
Published: January 2022

O Transtorno de Déficit de Atenção e Hiperatividade apresenta em sua história e descrição complexidades de significados, conceitos e algumas controvérsias. I consenso sobre a descrição ocorre de forma geral, porém sob o aspecto neuro-psiquiátrico, alguns cientistas apresentam discordâncias, o que influenciou a história do transtorno assim como seu processo evolutivo como patologia. Nessa perspectiva, o presente estudo propõe descrever a história do transtorno pontuando algumas especificidades e contradições. Para tal, a metodologia utilizada neste estudo é de caráter qualitativo, em relação aos objetivos, é uma pesquisa exploratória e descritiva e referente aos procedimentos de pesquisa, o estudo caracterizou-se como bibliográfico. A pesquisa foi realizada em meio virtual, em bases de dados confiáveis como Scielo, com artigos científicos e livros em formato pdf, com os descritores TDAH, história e evolução, que gerou resultados e discussão divididos em três tópicos: considerações gerais, contexto histórico e evolutivo e algumas notas. As considerações finais compreendem as impressões e conclusões da autora.
Transcendent God, Rational World
Authors: Harvey Ramon
Published: January 2022

This book is a constructive theological work that builds on the Māturīdī tradition of kalām, which is one of the main schools of Sunnī theology in Islam. It advances scholarship in three main respects. First, it provides a detailed treatment of the system of Abū Manṣūr al-Māturīdī (d. 333/944), a Ḥanafī theologian from Samarqand. This includes discussion of his epistemology, ontology, natural theology, and his treatment of the divine nature and several key attributes: omniscience, wisdom, creative action and speech. Second, the book analyses the development of the Māturīdī tradition after the lifetime of al-Māturīdī and into the classical period. There is a focus on unearthing underappreciated material from his immediate successors in Samarqand, as well as explaining the changes that emerge in the classical school, especially through its dialogue with Ashʿarism. Third, the book draws on the resources of the Māturīdī tradition to develop an original contemporary Islamic theology. This aspect pays special attention to the phenomenological tradition founded by Edmund Husserl, and to contemporary analytic philosophy of religion and Christian philosophical theology. The result is a unique proposal for a renewed Islamic theology that seeks a creative synthesis between the premodern Islamic tradition and elements of modern thought.
Political Imaginaries of the Weighted Average Cost of Capital: A Conceptual Analysis
Authors: Ortiz Horacio
Published: January 2022

This article analyzes the formulation of the “weighted average cost of capital” in the manuals of two of the most influential associations of financial analysts. It focuses on the use of the formula as the discount rate to determine the “fundamental value” of listed companies using the “discounted cash flows” method, a cornerstone of the definition of “shareholder value” used in the finance industry worldwide. It shows that the choice of variables and their mathematical relations in the formula mobilize multiple, partly independent and contradictory epistemologies and ontologies. This multiplicity is assembled along political imaginaries concerning the relation between particular notions of the maximizing investor, the efficient markets and the sovereign state. The figure of the investor is considered the only legitimate agent to claim the “free” cash flows of the company, the efficient markets are considered the source of truthful representation of value, and the state is supposed to guarantee both the fair play between investors and a minimum revenue for money owners, to be extracted from the rest of society through the tax system. The formula thus legitimizes and renders self-evident power relations that sustain the global inequalities produced by the finance industry.
Does Innovative Development Drive Green Economic Growth in Resource-Based Cities? Evidence From China
Authors: Zhang Ming , Yan Taihua , Ren Qingzhong
Published: January 2022

Seeking innovative development has become a necessity for global cities because of the accelerating consumption of natural resources and the increasing need for urgent control of environmental pollution. However, few studies have reported on the effect of innovative development on the green economic growth of resource-based cities. Therefore, this study aimed to construct the SBM model of unexpected output to measure the efficiency of green economic growth using data of 108 resource-based cities in China from 2004 to 2018, and to analyze the impact of innovative development and resource endowment on green economic growth using the systematic Generalized Method of Moments (GMM) model. The following results were obtained: first, the green economic growth efficiency of resource-based cities exhibited a general trend of fluctuation and rise, but the efficiency of different resource-based cities was different in time and space. Second, although innovative development promoted the green economic growth of resource-based cities, the impact of different resource-based cities was heterogeneous. Innovative development promoted the green economic growth of resource-based cities in eastern China, comprehensive cities, metal cities, growth cities, and renewable cities. However, it had an inhibitory effect on the green economic growth of northeast China, west China, and oil–gas and nonmetal resource–based cities, but no significant effect on the green economic growth of other resource-based cities. Third, the nonlinear effect of resource endowment on the green economic growth of resource-based cities was not significant, but resource endowment had a “curse” effect on green economic growth. Meanwhile, heterogeneity analysis showed two effects of resource endowment on the green economic growth in different resource-based cities: curse and blessing. Fourth, the impact of innovative development on the green economic growth of resource-based cities was moderated by resource endowment. The impact of innovative development on green economic growth decreased with the increase in resource endowment. Therefore, resource-based cities should not only constantly increase innovation and improve resource utilization efficiency but also actively promote coordination and cooperation of regional resource-based industries so as to achieve green and sustainable development.
Cloning and Functional Characterization of a Pericarp Abundant Expression Promoter (AhGLP17-1P) From Peanut (Arachis hypogaea L.)
Authors: Sharif Yasir , Chen Hua , Deng Ye , Ali Niaz , Khan Shahid Ali , Zhang Chong , Xie Wenping , Chen Kun , Cai Tiecheng , Yang Qiang , Zhuang Yuhui , Raza Ali , Zhuang Weijian
Published: January 2022

Peanut (Arachis hypogaea L.) is an important oil and food legume crop grown in tropical and subtropical areas of the world. As a geocarpic crop, it is affected by many soil-borne diseases and pathogens. The pericarp, an inedible part of the seed, acts as the first layer of defense against biotic and abiotic stresses. Pericarp promoters could drive the defense-related genes specific expression in pericarp for the defense application. Here, we identified a pericarp-abundant promoter (AhGLP17-1P) through microarray and transcriptome analysis. Besides the core promoter elements, several other important cis-elements were identified using online promoter analysis tools. Semiquantitative and qRT-PCR analyses validated that the AhGLP17-1 gene was specifically expressed only in the pericarp, and no expression was detected in leaves, stem, roots, flowers, gynophore/peg, testa, and embryo in peanut. Transgenic Arabidopsis plants showed strong GUS expression in siliques, while GUS staining was almost absent in remaining tissues, including roots, seedlings, leaf, stem, flowers, cotyledons, embryo, and seed coat confirmed its peanut expressions. Quantitative expression of the GUS gene also supported the GUS staining results. The results strongly suggest that this promoter can drive foreign genes’ expression in a pericarp-abundant manner. This is the first study on the functional characterization of the pericarp-abundant promoters in peanut. The results could provide practical significance to improve the resistance of peanut, and other crops for seed protection uses.
Immunotherapy With Interferon α11, But Not Interferon Beta, Controls Persistent Retroviral Infection
Authors: Schwerdtfeger Mara , Dickow Julia , Schmitz Yasmin , Francois Sandra , Karakoese Zehra , Malyshkina Anna , Knuschke Torben , Dittmer Ulf , Sutter Kathrin
Published: January 2022

Type I Interferons (IFNs), including numerous IFNα subtypes and IFNβ, are key molecules during innate and adaptive immune responses against viral infections. These cytokines exert various non-redundant biological activities, although binding to the same receptor. Persistent viral infections are often characterized by increased IFN signatures implicating a potential role of type I IFNs in disease pathogenesis. Using the well-established Friend retrovirus (FV) mouse model, we compared the therapeutic efficacy of IFNα11 and IFNβ in acute and chronic retroviral infection. We observed a strong antiviral activity of both IFNs during acute FV infection, whereas only IFNα11 and not IFNβ could also control persistent FV infection. The therapeutic treatment with IFNα11 induced the expression of antiviral IFN-stimulated genes (ISG) and improved cytotoxic T cell responses. Finally, dysfunctional CD8+ T cells solely regained cytotoxicity after IFNα11 treatment. Our data provide evidence for opposing activities of type I IFNs during chronic retroviral infections. IFNβ was shown to be involved in immune dysfunction in chronic infections, whereas IFNα11 had a strong antiviral potential and reactivated exhausted T cells during persistent retroviral infection. In contrast, during acute infection, both type I IFNs were able to efficiently suppress FV replication.
Swine Enteric Coronaviruses (PEDV, TGEV, and PDCoV) Induce Divergent Interferon-Stimulated Gene Responses and Antigen Presentation in Porcine Intestinal Enteroids
Authors: Yin Lingdan , Liu Xiang , Hu Dongmei , Luo Yi , Zhang Guozhong , Liu Pinghuang
Published: January 2022

Swine enteric coronaviruses (SECoVs) including porcine epidemic diarrhea virus (PEDV), transmissible gastroenteritis virus (TGEV), and porcine deltacoronavirus (PDCoV), account for the majority of lethal watery diarrhea in neonatal pigs and pose significant economic and public health burdens in the world. While the three SECoVs primarily infect intestinal epithelia in vivo and cause similar clinical signs, there are evident discrepancies in their cellular tropism and pathogenicity. However, the underlying mechanisms to cause the differences remain unclear. Herein, we employed porcine enteroids that are a physiologically relevant model of the intestine to assess the host epithelial responses following infection with the three SECoVs (PEDV, TGEV, and PDCoV). Although SECoVs replicated similarly in jejunal enteroids, a parallel comparison of transcriptomics datasets uncovered that PEDV and TGEV infection induced similar transcriptional profiles and exhibited a more pronounced response with more differentially expressed genes (DEGs) in jejunal enteroids compared with PDCoV infection. Notably, TGEV and PDCoV induced high levels of type I and III IFNs and IFN-stimulated gene (ISG) responses, while PEDV displayed a delayed peak and elicited a much lesser extent of IFN responses. Furthermore, TGEV and PDCoV instead of PEDV elicited a substantial upregulation of antigen-presentation genes and T cell-recruiting chemokines in enteroids. Mechanistically, we demonstrated that IFNs treatment markedly elevated the expression of NOD-like receptor (NLR) family NLRC5 and major histocompatibility complex class I (MHC-I) molecules. Together, our results indicate unique and common viral strategies for manipulating the global IFN responses and antigen presentation utilized by SECoVs, which help us a better understanding of host-SECoVs interactions.
Yorkie Negatively Regulates the Expression of Antimicrobial Proteins by Inducing Cactus Transcription in Prawns Macrobrachium nipponense
Authors: Huang Ying , Si Qin , Du Jie , Ren Qian
Published: January 2022

The Hippo signaling pathway controls organ size and immune system in Drosophila and mammals. Yorkie acts as a transcriptional co-activator in the Hippo pathway and cross-talks with other essential pathways. In this study, a Yorkie gene and two Cactus isoforms (designated as MnYorkie, MnCactus-a, and MnCactus-b, respectively) were isolated and characterized from oriental river prawns (Macrobrachium nipponense). Results showed that MnYorkie includes 1620 bp open reading frame and encodes a protein of 539 amino acids (aa). MnCactus-a (377 aa) and MnCactus-b (471 aa) were produced by alternative splicing. MnYorkie and MnCactus were continuously expressed in all selected tissues. Upon Gram-positive bacterium Staphylococcus aureus and Gram-negative bacterium Vibrio parahaemolyticus stimulation, the mRNA levels of MnYorkie and MnCactus in hemocytes and intestines underwent time-dependent enhancement. RNA interference studies showed that MnYorkie silencing remarkably downregulated the transcription of MnCactus but upregulated the expression of seven immune-related genes. In addition, MnYorkie silencing in vivo decreased the susceptibility of prawns to bacterial challenge. After S. aureus and V. parahaemolyticus infection, the survival rate of prawns increased significantly from 2 to 6 days, which corresponded to the period of MnYorkie knockdown. All these findings suggested that MnYorkie in the Hippo pathway might exhibit remarkable biological roles in the immune defense of M. nipponense by negatively regulating the expression of immune-related genes and promoting the transcription of MnCactus.
Thermohaline Temporal Variability of the SE Mediterranean Coastal Waters (Israel) – Long-Term Trends, Seasonality, and Connectivity
Authors: Ozer Tal , Gertman Isaac , Gildor Hezi , Herut Barak
Published: January 2022

The high variability of coastal waters together with the growing need for assessing the state of the marine coastal ecosystem, require continuous monitoring at exceptional resolution and quality, especially during the Anthropocene changing seas. We perform a comprehensive analysis of a decadal (March 2011 to June 2021) thermohaline variability of the East Levantine Basin (LB) coastal waters (continuous measurements), its predominating temporal trends and their linkage with atmospheric forcing and advection. We identify statistically significant long-term warming and salinification trends with yearly rates of 0.048°C and 0.006, respectively. Through the use of the X11-ARIMA method temperature and salinity inter-annual trends are examined and associated with previously published open ocean dynamics as well as model reanalysis. We study the linkage between Northern and Southern coastal locations, and identify the along shore northward current as a primary cause of positive temperature anomalies arriving from the south. The coastal salinity long-term trend demonstrates a connection to local precipitation. A less coherent seasonal sequence is found with a bimodal behavior, where, salinity values drop in August on several summers. This drop is attributed to the intensification of the along shore current in the period of June-July, potentially advecting more Atlantic Water. The observations presented here emphasize the relatively strong coupling between coastal water and the open ocean, the influence of the general surface circulation of the LB on the coastal zone and the faster response time and higher sensitivity of the coastal environment to atmospheric forcing.
Predictability Limit of Monsoon Intraseasonal Precipitation: An Implication of Central Indian Ocean Mode
Authors: Qin Jianhuang , Zhou Lei , Ding Ruiqiang , Li Baosheng
Published: January 2022

The prediction of monsoonal precipitation during Indian summer monsoon (ISM) remains difficult. Due to the high correlation between the Central Indian Ocean (CIO) mode index and the ISM precipitation variability, the predictability limit of the CIO mode index is investigated by the non-linear local Lyapunov exponent (NLLE) method in observations. Results show that the predictability limit of the CIO mode index can reach 38 days during boreal summer (from June to September), which is close to the upper predictability limit of intraseasonal precipitation (up to 40 days), and higher than the predictability limits of dynamical monsoon indices (under 3 weeks) and boreal summer intraseasonal oscillation (BSISO) indices (around 30 days). Such high predictability limit of the CIO mode index is mainly attributable to the long predictability limits from the intraseasonal sea surface temperature (SST) and intraseasonal zonal wind, which are the components of the CIO mode. As a result, the CIO mode is expected to extend the predictability of monsoonal precipitation, and benefits to improve the prediction skills of the ISM.
Comparison of the Effects of Microbial Inoculants on Fermentation Quality and Microbiota in Napier Grass (Pennisetum purpureum) and Corn (Zea mays L.) Silage
Authors: Jaipolsaen Narongrit , Sangsritavong Siwat , Uengwetwanit Tanaporn , Angthong Pacharaporn , Plengvidhya Vethachai , Rungrassamee Wanilada , Yammuenart Saowaluck
Published: January 2022

Forage preservation for livestock feeding is usually done by drying the plant material and storing it as hay or ensiling it into silage. During the ensiling process, the pH in the system is lowered by the activities of lactic acid-producing bacteria (LAB), inhibiting the growth of spoilage microorganisms and maintaining the quality of the ensiled product. To improve this process, inoculation of LAB could be used as starter cultures to shorten the ensiling time and control the fermentation process. Here, we compared fermentation quality and bacterial dynamics in two plant materials, whole-plant corn (Zea maysL.) and Napier grass (Pennisetum purpureum), with and without starter inoculation. The efficacy ofLactobacillus plantarum,L. brevis, andPediococcus pentosaceusas starter cultures were also compared in the ensiling system. In whole-plant corn, pH decreased significantly, while lactic acid content increased significantly on Day 3 in both the non-inoculated and LAB-inoculated groups. Prior to ensiling, the predominant LAB bacteria wereWeissella,Enterococcus, andLactococcus, which shifted toLactobacillusduring ensiling of whole-plant corn in both the non-inoculated and LAB inoculated groups. Interestingly, the epiphytic LAB associated with Napier grass were much lower than those of whole-plant corn before ensiling. Consequently, the fermentation quality of Napier grass was improved by the addition of LAB inoculants, especiallyL. plantarumand a combination of all three selected LAB strains showed better fermentation quality than the non-inoculated control. Therefore, the different abundance and diversity of epiphytic LAB in plant raw materials could be one of the most important factors determining whether LAB starter cultures would be necessary for silage fermentation.