bluuebunny/crossref_metadata_2025 huggingface dataset:
INTERPRETAÇÃO DE CARTAS DINAMOMÉTRICAS DE UM CAMPO ONSHORE LOCALIZADO NA BACIA DE SERGIPE
Authors: Da Luz Ianara Bomfim , Chaveiro Marcela Morgana Bonifácio , Silva Lays Pinheiro Sedrins , Limeira Vanessa , Costa Júnior Marcos Antônio
Published: December 2020

No Brasil, aproximadamente 73,5% dos poços petrolíferos são equipados por bombeio mecânico (BM), sendo o método de elevação artificial de petróleo mais empregado no mundo. O bombeio mecânico consiste em uma unidade de bombeio, um motor instalado na superfície, coluna de hastes e bomba de fundo. A aplicação deste método tem grande relevância em campos onshore, pois possibilita e otimiza a produção em poços maduros. Além das vantagens, esse método dispõe também do diagnóstico de problemas e/ou falhas que é analisado através das Cartas Dinamométricas de Fundo (CDF) e de superfície (CDS). Tais falhas podem ocasionar diminuição da eficiência volumétrica e, de modo consequente, ocorrer déficit na produção no poço. Assim, o presente estudo analisou e interpretou as cartas Dinamométricas do poço denominado 7-ILM-03-SE através do software TAM (Total Assent Monitor) da empresa Echometer e do hardware Sonolog, em uma unidade de bombeio mecânico com haste polida. Como resultados, os principais problemas apresentados no BM foram “pancada” de fluido, haste partida e golpe de bomba. Desta forma, é possível relatar em grande relevância a eficiência volumétrica, apontando qual falha apresenta mais prejuízo à unidade de bombeio, a CDF que apresentou maior eficiência com 77,3% foi a carta ideal, por outro lado a CDF com golpe (batida) de bomba mostrou a menor eficiência volumétrica com 63,3% estando inferior aos padrões recomendados, classificada a falha que acarretou mais malefícios a unidade de bombeio.
Pharmacoeconomic analysis of therapy with brentuximab vedotin, nivolumab and pembrolizumab in patients with relapsed Hodgkin’s lymphoma
Authors: Avxentyev N. A. , Pazuhina E. M. , Tumyan G. S. , Zeynalova P. A.
Published: December 2020

Background. In the Russian Federation, in 2018 3,207 new cases of Hodgkin’s lymphoma (HL) were detected, mainly in adults. Despite significant advances in the treatment of this disease, approximately 20–30 % of patients develop relapses. High-dose chemotherapy with autologous hematopoietic stem cell transplantation is the standard 2nd line therapy. Patients with relapse after autologous hematopoietic stem cell transplantation have a poor prognosis. Brentuximab vedotin, nivolumab, and pembrolizumab are indicated for treatment of relapsed HL after autologous stem cell transplantation.

The objective of this study is to conduct budget impact analysis of increasing the share of patients with relapsed HL, who are treated with brentuximab vedotin.

Materials and methods. We estimated medication costs of using brentuximab vedotin, nivolumab, and pembrolizumab based on clinical trials data. The number of patients who annually start treatment using these alternatives was determined using data on purchases of drugs by public health funds in 2019. Budget impact was defined as the difference in public health expenditures on medications in case of increase in brentuximab vedotin share by 10 or 20 percentage points compared to current practice, with a proportional decrease in the share of patients, who receive nivolumab or pembrolizumab. Time horizon was 6 years.

Results. Expenses for treatment of a single patient with relapsed HL within 6-year study horizon using brentuximab vedotin (7.07 million rubles) were 2.15 million rubles less than in case of treatment with nivolumab, and 4.38 million rubles less than for pembrolizumab. There are 295 patients with relapsed HL, who start treatment with brentuximab vedotin, nivolumab or pembrolizumab annually. If the proportion of patients, who start therapy using brentuximab vedotin, increases from the current 60 % to 70 %, cost savings over 6 years will be 171 million rubles, which corresponds to extra 24 patients who can be treated using brentuximab vedotin without increasing budget expenditures. If the proportion of patients with relapsed HL receiving brentuximab vedotin increases to 80 %, savings in public health funds over 6 years will amount to 341 million rubles, which allows treating 48 additional patients with brentuximab vedotin without budget increase.

Conclusion. Brentuximab vedotin is a cost-saving treatment option of relapsed HL, compared to nivolumab and pembrolizumab. Increasing share of patients, who receive brentuximab vedotin, allows treating additional patients without increase in public health budget.
RHD and RHCE genes polymorphism: literature review
Authors: Golovkina L. L. , Kalandarov R. S.
Published: December 2020

The article provides a literature review about RHD and RHCE polymorphisms which encode different RhD and RhC antigen variants. The data about genes RHD and RHCE polymorphisms, RhD weak types, RhD partial types and RhC variants in Russians is presented for the first time. The molecular and serological characteristics of rare RhD and RhC antigens are summarized. The role of serological and molecular methods in Rhesus system antigens identifying is shown.
Anorexia-cachexia syndrome in cancer patients: pathogenetic aspects and treatment options
Authors: Snegovoy A. V. , Larionova V. B. , Kononenko I. V.
Published: December 2020

Background. Modern standards for the treatment of both solid tumors and tumors of the blood system provide a mandatory assessment of the objective status of the patient. One of the important criteria of which is nutritional status. Underestimating the role of nutritional support in the treatment of cancer patients leads to a deterioration of treatment results due to the progressive deterioration of nutritional status and the development of cancer anorexia cachexia syndrome (CACS), which is an independent adverse factor leading to the death of the patient. The increase in the number of cancer patients with risk factors for CACS development requires not only close attention of clinicians to this problem, but also the development of clear recommendations for the diagnosis and management of such patients. This can contribute to solving several problems at once. First, it will allow optimizing monitoring of cancer patients predisposed to CACS development during anticancer treatment. Secondly, it will provide an opportunity to develop a diagnostic algorithm to prevent it. Third, the use of the identified criteria for predicting and outcome of complications both on an outpatient basis and in a hospital will be aimed at creating favorable conditions for anticancer therapy and thereby improving long-term treatment results and patients quality of life. Studying the mechanisms of development of CACS, the possibilities of correcting this condition, indicate the need for a multimodal concept and the rejection of the search for a “magic pill”. The results of a multicenter, prospective randomized study conducted in the oncology and hematology departments of healthcare institutions.

Objective: to evaluate the effectiveness of FortiCare oral nutritional support in cancer patients under the real clinical practice.

Materials and methods. The study included 96 patients with stage II–IV tumors. Radiation therapy was received by 28 patients, chemotherapy ‒ by 68 patients. Patient information was collected using an individual registration card. The patients were randomized according to nutritional support tactics (1:1). In the study group, with radiation (n = 14) and chemotherapy (n = 34), patients received enteral nutrition Forticare orally 125 ml 3 times a day in parallel with their usual diet. Patients in the control group during radiation therapy (n = 14) received the required amount of calories from their usual diet. During chemotherapy, patients in the control group (n = 34) with a lack of daily calorie intake received additional parenteral nutrition.

Results and conclusion. While taking FortiCare, there was a smaller loss of body weight (p ≤0.05), a frequency of mucositis of the oral cavity, and esophagitis (p >0.05). With chemotherapy, the incidence of diarrhea (p <0.001) and constipation (p <0.05) was detected less frequently than in the control group. A decrease in the frequency of hematological toxicity (leukopenia, thrombocytopenia) was noted (p >0.05).
Neurological complications and pathogenetic therapy for chronic nitrous oxide intoxication (“laughing gas”) in nightclub visitors
Authors: Suponeva N. А. , Grishina D. А. , Grozova D. А. , Belova N. V. , Ginzberg М. А. , Rizvanova А. S. , Piradov М. А.
Published: December 2020

Background. Nitrous oxide abuse (“laughing gas”, N2O) is common among young people attending nightclubs. Contrary to popular belief about the safety of N2O, in some cases neurological complications develop due to a deficiency of vitamin B12, the activity of which is blocked by N2O. Purpose of the study – to determine the typology and course of neurological disorders in a group of patients who regularly use “laughing gas”. To note the key diagnostic markers that allow verification of vitamin B12 deficiency induced by nitrous oxide consumption. To describe pathogenetic therapy features and follow-up. Materials and methods. The study included 12 patients (10 men and 2 women) aged 18 to 45 years (average age 29 years) with a diagnosis of B12-deficient myelopolyneuropathy induced by regular use of nitrous oxide. Results. The most common neurological complication of nitrous oxide abuse for more than 1 month was a generalized lesion of the peripheral nerves with acute or subacute distal symmetric sensory or sensorimotor axonal polyneuropathy. In the clinical picture, sensory complaints and disorders prevailed. Paresis developed in half of the cases. A typical neuroimaging symptom characteristic of funicular myelosis was rarely detected (16.7 %). A decrease in B12 vitamin level could most reliably be diagnosed only indirectly, by the presence of hyperhomocysteinemia (91.7 % of cases). In all cases that were followed-up, prolonged therapy with cyanocobalamin led to partial (n = 5; 62.5 %) or complete (n = 3; 37.5 %) regression of neurological symptoms. Conclusion. Caution regarding the use of nitrous oxide should be in all cases of predominantly sensory polyneuropathy with acute or subacute development in young and middle-aged people. A thorough history taking (targeted survey on the fact of nitrous oxide consumption) and diagnostics (testing the level of homocysteine, if possible methylmalonic acid) allow you to not miss a deficiency of vitamin B12, the treatment of the consequences of which with timely verification and adequate correction is quite effective. It is recommended that the level of homocysteine in the blood to be regularly monitored during the treatment (in order to achieve its normalization).
Long-Acting Injectable Drugs in the Maintenance Therapy of Patients with Schizophrenia
Authors: Petrova Natalia N. , Serazetdinova Valeria S.
Published: December 2020

This article discusses case reports of treatment with paliperidone palmitate in comparison with data from recent publications. Second-generation long-acting injectable antipsychotics have been shown to provide better control of psychiatric manifestations, reduce the severity of negative symptoms, improve social functioning and quality of life of patients and relatives, and reduce the burden of disease for both the healthcare system and the caregivers. The case reports presented in this article demonstrate better quality of remission in schizophrenia patients treated with one- monthly and three-monthly paliperidone palmitate formulations, due to higher effi in preventing relapses, better safety and good tolerability regardless of patient age.
ART THERAPY AS A METHOD OF REHABILITATION OF MILITARY OPERATIONS' PARTICIPANTS UNDER CONDITIONS OF THE RUSSIAN-UKRAINIAN ARMED CONFLICT
Authors: Averianova Nina
Published: December 2020

It is shown that participation in hostilities affects a person's psychological state. Being in a combat zone can dramatically change the personality and often - negatively. Mental injuries received during combat operations lead to a number of complex disorders in the physical and emotional spheres of man. This leads to various conflict situations in society. The destructive effects of war are manifested not only in physical losses, but also in social disorientation, loss of social contacts, the integrity of the "I" and theс personal identity of both servicemen and civilians. The consequences of combat mental trauma in various manifestations can be seen even after many years. Without proper psychological rehabilitation, it is difficult for such people to return to a peaceful life and to their social role in society. Therefore, art therapy can come to the rescue here, which in a set of rehabilitation measures can relieve a person of negative feelings, encourage him and help build new life patterns.
It is indicated that art therapy was formed as a specific activity that includes art, psychology and psychotherapy. Usually art therapy is part of a set of rehabilitation measures; she has certain advantages in diagnosis. Important aspects of the art therapist's work are his professional contacts with colleagues – psychiatrists, nurses, social workers and others. Attempts to use art therapy techniques without close contact with healthcare professionals are often considered unethical and can be harmful to patients. It is proved that art therapy helps to reduce depressive symptoms and aggression, helps to correct behavior, improve communication skills and integration into society.
IDEOLOGICAL AND POLITICAL INFLUENCE OF THE CYRIL AND METHODIUS BROTHERHOOD’S CONCEPT ON THE FORMATION OF THE NATIONAL MILITARY SPHERE AT THE END OF THE 19h – AT THE FIRST HALF OF THE 20th CENTURY
Authors: Tsiurupa Mykhailo
Published: December 2020

Based on the ideas of historicism and continuity in the development of political and scientific concepts, the article traces the influence of the Cyril and Methodius concept on the creation of an independent state on the principles of respect of the national identity of the Ukrainian people, its leading role in liberating all Slavic peoples from the tsarist government and choosing democratic institutions and the structure of the state following the example of the Federation of North American States. On this basis, the further humanistic tradition of Ukrainians in creating their own military sphere is revealed. Insufficient attention to it had led to sad consequences - the inability to defend the revolutionary achievements of the civil war in the 20s of the last century, the defeat of the national liberation armed resistance to the Stalinist-Bolshevik regime of 30-40's XX centuries in Western Ukraine, the lack of modern military doctrine at the intersection of the XX - XXI centuries and a weakened military organization, which at first could not adequately resist Russian aggression in eastern Ukraine.
However, the positive influence of the Methodists on this part of the national spirit and existence was to foster a new generation of fighters, humanists, scientists to activism and the creation of a theory (doctrine) of the Ukrainian national military sphere. The concept of the Cyril and Methodius was a synchronous liberation movement of Ukrainians together with other Slavic peoples, to jointly oppose the tsar and rely on the strength of the armed people, without elaborating on the army, military organization in general. According to the methodological guidelines, to evaluate the achievements of predecessors not by mistakes, but by what had been done, the humanistic tendency of prominent members of the society to struggle for the freedom in Ukraine is revealed. Cyril and Methodius inspired (Ipokrena) a new generation of fighters, humanists, scientists of the "Kiev" military-theoretical school to substantiate the peculiarities of the Ukrainian national military sphere.
The next generation of Ukrainian thinkers managed to realize the urgent need to create the theoretical foundations of the military sphere on the borderline synthesis of democracy, humanism, revolutionary romance of members of the Cyril and Methodius Society with strict requirements of military necessity.
PERSONALITIES OF LEADERS OF THE UKRAINIAN CHURCH IN THE CREATIVE HERITAGE OF THE MEMBERS OF CYRIL AND METHODIUS BROTHERHOOD
Authors: Kahamlyk Svitlana
Published: December 2020

The literary and scientific heritage of the leaders of the Cyril and Methodius Brotherhood are analyzed in the article. The place of church themes and socio-cultural activities of the leaders of the Ukrainian Church is determined in this works. A comparative analysis of the creative work of P. Kulish and M. Kostomarov in the field of presentation and evaluation of individual figures of the senior Ukrainian clergy is done. It was concluded that history of the Ukrainian Church is largely represented in their works, but the disclosure of church themes in the creative work of each of the authors had its own peculiarities.
The historical works of P. Kulish of the early period reflected the creative pursuits of the members of the Kyiv-Methodius Brotherhood and were typical of their environment. P. Kulish expressed his own view on the role of the clergy in history through the prism of the heroes of the Black Council, in particular, the priest I. Shram, as an important factor in Ukrainian cultural and state-building processes. At the same time, the evolution of P. Kulish's views led him to the idea of a dual Russia, in the light of which the writer's positive assessment was mainly received by those church figures who contributed to it.
Unlike P. Kulish, who did not deal with history of the Church in Ukraine, M. Kostomarov became the first secular researcher who created its holistic concept. The archpastoral activities and literary works of prominent clergy of the XVII century from Petro Mohyla to Dimitri Tuptal are analyzed in his series "Russian history in the biographies of its main figures" as so as their influence on Ukrainian and Russian culture is emphasized. Therefore, M. Kostomarov can rightly be considered one of the creators of the Ukrainian secular historiography of the history of the Church, the main merit of which is the creation in this area of separate monographs and numerous studies of a biographical nature.
INVESTIGATING RELATIONSHİP BETWEEN TEACHERS’ PSYCHOLOGICAL RESILIENCE AND STUDENT RELATED SOCIAL STRESS
Authors: Kinay İsmail , Süer Sedef , Altındağ Kumaş Özlem
Published: December 2020

Stress is known as one of the most important factors affecting teachers’ performance thus knowing the source of the stress is important in terms of coping with stress and increasing teacher resilience.The purpose of this study was to determine the relationship between the resilience and student-related social stress levels of teachers working at nursery, primary, secondary and high school levels in terms of different variables. Conducted on the basis of correlational survey method this study consisted of 454 teachers randomly selected among the teachers of various subjects working in Diyarbakır, southeast of Turkey. In this study “Resilience Scale for Adults” and “Teacher Social Stress Scale-Student Related” were used as data collection instruments. The findings showed that teachers’ student-related social stress level is lower than the moderate level while teachers’ resilience level is higher than the moderate level. A negative significant relationship was observed between teachers’ student-related social stress and psychological resilience. A significant difference was not observed between teachers’psychological resilience and student-related social stress in terms of gender variable. A significant difference was not observed between teachers’ psychological resilience in terms of school location while there is a significant difference between teachers’ student-related social stress in terms of school location. This study provides important data about the relationships between resilience and student-related social stress, thus the results are considered to contribute not only to teachers but also to the preservice teachers.
Practice Teaching Reformation of "Four Segments Integration" of Marketing Based on OBE Theory
Authors: Yi Gu, Dong Liang, Chenwei Zhao
Published: December 2020

With the rapid development of Internet and information technology, the continuous impact of the new epidemic on the global economy, the market environment has put forward new requirements for marketing personnel. This paper systematically analyzes the current demand for marketing talents, scientifically expounds the concept of OBE education mode, and summarizes the experience of the reform of practical teaching system based on the OBE concept for engineering majors at home and abroad. In view of the current situation of talent training of marketing major in Jianghan University, this paper puts forward the reform ideas of " Four segments integration", including deepening experimental curriculum design, strengthening discipline competition, optimizing practice process and strengthening risk management, in order to innovate the teaching mode of marketing specialty and improve the quality of marketing teaching.
Research on Sense of Fulfillment, Happiness and Security of Talents in New Era
Authors: Yunna Liu, Hao Wang
Published: December 2020

This research chooses the talents of the new era as the research object and the sense of fulfillment, happiness and security as the foothold. Through the research on the sense of fulfillment, happiness and security of the talents in the new era, the paper demonstrates talents how to make a good career planning and development, so as to improve the quantity and quality of employment. After consideration of the relationship between the sense of fulfillment, happiness, and security of talents, the paper illustrates talents should cognize the overall status of career development, increase self-awareness of values, interest and skills, know the occupation choices and understand the industry in New Era.
FACTORS AFFECTING THE PERFORMANCE OF GRAIN COOPERATIVE SOCIETIES IN LATVIA
Authors: Mistris Jānis , Mistre Baiba , Zvaigzne Anda
Published: December 2020

The present research continues and complements previous research by the authors on the performance of grain cooperative societies in Latvia. The research aim is to identify and assess the factors affecting the performance of grain cooperative societies in Latvia.The research results revealed that the main endogenous factor hindering the performance of grain cooperatives was technological – underdeveloped grain processing –, as the cooperatives did not own processing enterprises, which was mainly due to an unclear situation in the sales market. The industry experts referred to the socio-economic factor as the key opportunity for improving the performance of cooperative societies – cooperation between small cooperative societies and large ones within the industry –, as well as the promotion of cooperation with scientists, technological progress and the positive effects on industry development in the country and the region. The research results revealed that the main threat to the development of cooperative societies was the political factor – possible sudden and significant changes in the national agricultural policy, which might be affected by the turnover of policy makers and the priorities set for the industry, as well as the economic situation in the country.The research employed the following methods: monographic, induction and deduction, graphical, comparison, a sociological research method – structured expert surveying –, SWOT analysis, pairwise analysis and statistical analysis.
CULTURALLY RESPONSIVE TEACHING OF IMMIGRANTS IN ADULT EDUCATION: A CASE STUDY IN SWEDEN
Authors: Ahrens Andreas , Zascerinska Jelena , Melnikova Julija , Jurgaityte Virginija , Aleksejeva Ludmila , Gukovica Olga
Published: December 2020

Adult education has been criticized for its lack of focus on sociocultural aspects of individual learners, largely ignoring the importance of cultural identity to the learning process. The article’s aim is to investigate culturally responsive teaching of immigrants in adult education, theoretically and empirically underpinning the implementation of a case study for the elaboration of implications on culturally responsive teaching of immigrants in adult education. Research methods include theoretical and empirical methods. Theoretical methods imply analysis of theoretical sources and theoretical modelling. The empirical study was based on a case study. The sample was composed of 20 adult learners and three teachers of Swedish in May 2019 and February 2020. The case study was implemented at Folkuniversitetet, Kristianstad, Sweden. The theoretical findings allow defining religion and human comfort conditions such as thermal comfort as the dimensions of cultural norms and values to be addressed by culturally responsive teaching of immigrants. The findings of the empirical study allow drawing the conclusion on the necessity of a personalised approach to an adult learner in culturally responsive teaching of immigrants. The novelty of the present work is revealed in the implications on culturally responsive teaching of immigrants. Further research is proposed.
EMERGING INFLUENCERS PROMOTING TRAVEL: THE CASE OF LOCAL TOURISM IN LATVIA
Authors: Berjozkina Galina , Garanti Zanete
Published: December 2020

The presence of social networks has given a chance for social media influencers to emerge. Social media influencers creating and sharing content, endorsed or not, has become a growing marketing trend used by companies, as well as destinations. This article focuses on travel influencers who, with a help of social networks, particularly Instagram, are promoting local travel in Latvia. In this study, four emerging travel influencers and their posts were retrieved and analysed. The study results show that emerging travel influencers are trying to attract their followers by mostly sharing posts with landscapes and nature, art objects/statues, and nature activities/facilities. However, traditional artwork/objects, religious buildings/objects, and traditional or historic buildings are the pictures achieving the highest engagement rates. Finally, the study also relieved that influencers with a lower number of followers have a higher level of engagement. It is concluded that authenticity and individuality of account, as well as its organic, rather than paid growth, are the key aspects in creating a travel account that followers would engage (like, share and comment on the content). The theoretical and practical implications are discussed.
DESIGN OF AMMONIUM STRIPPING TOWER AND OPTIMIZATION OF AMMONIUM REMOVAL FROM LANDFİLL LEACHATE
Authors: OZTEKIN Melike , AKGUL Vildan , DUYAR Ahmet , GOCER Serdar , CIRIK Kevser
Published: December 2020

Landfill leachates are complex wastewater which has high pollution and their biological degradability is also difficult. Landfill leachate with high concentrations of contaminants must be pretreated. For this reason, the ammonium stripping process is an effective method for ammonium removal, especially for landfill leachate. With the ammonium stripping process, the ammonium and organic matter removal increases. This study aimed to investigate the applicability of the ammonium stripping process as remove ammonium (NH4+) and chemical oxygen demand (COD) from raw leachate. A new system has been designed which is called ammonium stripping tower. During this study, the ammonium stripping process was operated temperature (30-40-60oC), aeration rate (HH, HL, LL m3air/min), and hydraulic retention times (6-12-24-48 h). System performance was evaluated by ammonium, and COD parameters. The optimum conditions of the ammonium stripping process were determined at 600C temperature, HH(1m3air/min aeration rate), and hydraulic retention time (48h). The corresponding ammonium and COD removal efficiencies were about 88% and 79% respectively. The results of this study suggest that the use of an ammonium stripping process is an effective way to remove ammonium and COD concentration from raw landfill leachate.
STABLE MERCURY ISOTOPE FRACTIONATION BEHAVIOURS OF PLANTS
Authors: DOĞRUL SELVER Ayça
Published: December 2020

The overarching aim of this study is to define mercury (Hg) isotopic features of plants which have different photosynthetic pathways (C3, C4 and CAM) and to understand if different parts of the plants have different Hg isotopic fractionation behavior. For this, carbon isotopic values of terrestrial plants were analyzed which were used to determine the photosynthetic pathways of plants. Plants were sub-sampled into leaves, stems and roots and their Hg isotopic values were analyzed.

Results showed that C3 and C4 plants exhibit mass dependent (even Hg isotopes) and mass independent Hg isotope fractionation (odd Hg isotopes). Both C3 and C4 plants are enriched in light isotopes, but the degree of mass fractionation is approximately three times greater in C3 plants, than in C4 plants. Hg in both C3 and C4 plants exhibit negative MIF isotope effect which reported as depletion “and no clear MIF effect. These findings suggest a connection between the Hg isotopic composition and the photosynthetic pathway.

In addition, the leaves are slightly more fractionated than the roots. Differences in the degree of MIF between roots and leaves suggest that they obtain Hg from different sources.
ADVANCED TECHNOLOGIES FOR FIBER REINFORCED POLYMER COMPOSITE MANUFACTURING
Authors: UZAY Çağrı , GEREN Necdet
Published: December 2020

Developments for improving the effectiveness of the composite structures strongly depend on the manufacturing methods. Additionally, the composite manufacturers have put effort into cost-effective and automated fabrication with mechanization. Controlling of the imperfections is also an important consideration for the production. This study presents several manufacturing methods for fiber-reinforced polymer composites. It also draws attention to novel techniques that use advanced technology required for the developed composite designs. Besides the conventional methods such as hand lay-up, vacuum bag, resin transfer molding, resin infusion, and autoclave, the advances in hot press molding, pultrusion process, and automated lay-up method were indicated. Moreover, the methods making difference for the hybrid composite designs such as the same qualified resin transfer molding and automated stitching processes were introduced. The advantages and limitations were indicated for the manufacturing methods and the usage purposes were addressed.
Acute effect of aerobic and resistance exercises on cardiovascular and neuromuscular responses in normotensive
Authors: Ruiz Roberto José , Pires Paulo Fernandes , Pelai Elisa Bizetti , Castro Ester Moreira de , Mescollotto Fabiana Foltran , Moreno Marlene Aparecida , Bigaton Delaine Rodrigues
Published: December 2020

Introduction: the literature report the effect of different types of exercise (aerobic and resisted) on cardiovascular and neuromuscular behavior after exercise. Objective: the objective of this study was to verify the acute effect after a resisted or aerobic exercise session on arterial pressure (BP), heart rate (HR), muscular strength and electromyography (EMG) activity of the rectus femoris (RF), vastus lateralis (VL) and vastus medialis (MV) in normotensive individuals. Method: the study included eight men (27.3 ± 3.1 years, 76.4 ± 9.7 kg, 1.80 ± 0.10 m, 24.3 ± 1.6 kg/m2 ), physically active individuals who randomly performed an aerobic exercise session (treadmill, 30 min, 60-70% of the reserve heart rate), or a resisted exercise session (nine exercises, three sets, 70% 1RM, 8 -12 repetitions). The BP, HR, EMG and muscle strength, were analyzed at rest before exercise and for 60 min after exercise. Results: as a result, systolic BP after the exercises (aerobic and resisted) remained lower than the pre-exercise rest values, with 30, 45 and 60 min (p<0.05) of recovery. On the other hand, the diastolic BP was lower after resistive exercise in all periods of recovery (p <0.01) in relation to pre-exercise. HR values remained elevated after aerobic and resisted exercise, in all recovery periods (p <0.05). Muscle strength and electromyography activity did not show significant differences after exercise. Conclusion: independently of the exercise type, occurs post-exercise hypotension (PEH), increase the HR during the recovery period and reestablishment of muscle strength and myoelectric activity of muscles compared to pre-exercise.
THE 55th ANNIVERSARY OF PROFESSOR O.R. KOTSYURBENKO
Authors: Frolov Oleg Alekseevich , Glagolev Mikhail Vladimirovich
Published: December 2020

Overview of the famous Ugra scientist Oleg R. Kotsyurbenko's scientific activities is given in connection with his anniversary. In the article presented separate publications by Prof. Kotsyurbenko, for some of them a brief summary. All the works under discussion are divided into two categories: microbiology and ecology. In addition, we are given a brief biography of O.R. Kotsyurbenko and a number of little-known photographs from different periods of his life.
Response of Germination and Seedling Development of Cotton to Salinity under Optimal and Suboptimal Temperatures
Authors: ERGİN Nurgül , KULAN Engin , GÖZÜKARA Mehmet , KAYA Muhammed , ÇETİN Şaban , KAYA Mehmet Demir
Published: December 2020

The objective of the study was to investigate the effects of salinity stresses (50, 100, 150, 200 and 250 mM of NaCl) on germination and early seedling growth of six cotton varieties (Lydia, Carisma, Flash, BA151, BA525 and ST468) under optimum (25°C) and low temperature (18°C) conditions. Germination percentage, mean germination time, germination index, germination stress tolerance index, seedling length, vigor index, seedling fresh and dry weight of cotton varieties were investigated. Results showed that low temperature led to decreasing in germination and seedling growth, and caused retardation of mean germination time. Under suboptimal temperature, germination percentage reduced from 86.3% to 77.8% and seedling length decreased from 12.02 cm to 5.36 cm. Each increase in salinity levels higher than 50 mM resulted in decreasing in germination and seedling growth parameters of cotton varieties. No seedling growth was observed at 250 mM of NaCl at 18°C. Cotton varieties showed different tolerance levels to salinity, while they could tolerate it up to 100 mM. It was concluded that Flash and ST468 varieties exhibited better performance under salinity stresses both at optimal and suboptimal temperatures.
Sumbas İlçesi Koşullarında Yetiştirilen Yerel Cin Mısır (Zea mays everta) Popülâsyonlarının Kalite Kriterlerinin Belirlenmesi
Authors: İDİKUT Leyla , ÖNEM Mustafa , ZULKADİR Gülay
Published: December 2020

Bu araştırma yerel cin mısır popülasyonlarının Osmaniye ili Sumbas ilçesi koşullarında verim performanslarının araştırılarak bu ekolojiye uygun yüksek verimli ve kaliteli cin mısır çeşitlerini belirlemek amacıyla 2014 yılında yürütülmüştür. Tesadüf blokları deneme desenine göre dört tekerrürlü olarak kurulan bu araştırmada 2 adet yerel cin mısır çeşidi ve 15 adet yerel cin mısır popülasyonu kullanılmıştır. Araştırmada incelenen popcorn genotiplerinin kalite özelliklerinin en düşük ve en yüksek değerler sırasıyla bin tane ağırlığının 128.79 - 181.06 g, patlamayan tane oranının % 0.02 - 0.08, patlama oranının % 0.93 - 0.98, 50 g tanenin patlama hacminin 15.55 - 21.78 cm3 g-¹, protein oranının % 8.44 - 16.65, yağ oranının % 3.003 - 6.65), kuru madde oranının % 86.65 - 88.003, nişasta oranının % 76.76 - 80.17 arasında değiştiği tespit edilmiştir. Sonuç olarak en yüksek protein ve yağ değeri Sakarya Han köyünden toplanan popülasyondan elde edildiği ve patlama oranının da iyi olduğu kaydedilmiştir. Yerel cin mısırı popülasyonlarından Bafra Koşuköy, Çanakkale Patlak, Balıkesir Beyaz Cin ve Çanakkale Beyaz Cin mısır populasyonları 1000 tane ağırlığı; Samsun Beyaz Cin ve Kdirli Cin mısır populasyonları patlama oranları; Çanakkale Sarı Cin, Samsun Merkez ve Bafra Koşuköy mısır populasyonları patlama hacmi; Sakarya Hanköyü protein, yağ ve nişasta oranları bakımından ve Edirne Beyaz Cin, Kadirli Cin ve Çanakkale Patlak mısır populasyonları kuru madde oranı yönünden ticari çeşit olan Nermin Cin ve Ant Cin 98’den daha yüksek değerlere sahip olduğu belirlenmiştir.
Benchmarking of the Effects of Salinity on Antioxidant Enzymes Activities, Lipid Peroxidation and H2O2 Levels in the Leaves of Two Zinnia Species
Authors: YASEMİN Sara , GÜZEL DEĞER Ayşin , ÇEVİK Sertan , KÖKSAL Nezihe
Published: December 2020

In this study, it was aimed to investigate the effects of salinity, which is an important environmental problem, in the cultivation of ornamental plants (such as zinnia) and irrigation with high salt water, especially on the antioxidant defense mechanism. For this purpose, the two Zinnia species were irrigated by different concentrations of saline water (50, 100, 150, 200 mM NaCl); effects of salinity on superoxide dismutase (SOD), catalase (CAT), glutathione reductase (GR) lipid peroxidation (MDA) and hydrogen peroxide (H2O2) in the leaves were determined. The results showed that salinity conspicuously increased SOD, CAT, GR, H2O2 and MDA content at two Zinnia species compared to the control groups. It was found that SOD and CAT enzyme activities increased remarkably with 150 mM NaCl in both Zinnia species, but decreased with 200 mM NaCl.The highest GR enzyme activity was observed in 200mM salt concentration at Zinnia marylandica ‘Double Zahara Fire Improved’. MDA and H2O2 levels were observed higher in Zinnia elegans ‘Zinnita Scarlet’.To conclude; it may be said that these two Zinnia varieties can tolerate salt concentration up to 150 mM.
The Use of Fourier-Transform Infrared Spectroscopy to Determine Potential Starch-based Prebiotics
Authors: GURBANOV Rafig , TUNÇER Sinem
Published: December 2020

Probiotics play important roles in many crucial functions for maintaining the homeostasis of the host, such as protection against pathogens, immunity and metabolism of dietary compounds. Resistant starch (RS) is the starch or the starch products which cannot be digested through the body, but can be digested by the gut microbiota, producing a variety of metabolites which can provide a range of physiological benefits to the host. An RS can be classified as a prebiotic if it can selectively stimulate the growth and/or activity of the beneficial bacteria. To investigate the bacteria driven structural changes in the prebiotic tapioca starch, we used Attenuated Total Reflectance-Fourier Transform Infrared (ATR-FTIR) spectroscopy. Principal Component Analysis (PCA) and intensity analyses of individual spectral bands exhibited comprehensive alterations in the polysaccharide composition of the tapioca starch incubated with the probiotic bacteria; the starch samples incubated with the bacteria gained a more amorphous structure with a decrease in the ordered structure. The results suggest that as a fast, cheap, and non-laborious method, FTIR spectroscopy coupled with PCA has a potential to be applied in the research area as well as in the food industry for the analysis of the potential prebiotic activity of starch-based substrates or the investigation of the probiotic potential of a bacterial strain through the examination of its RS hydrolyzing capacity.
MANUTENÇÃO DE REGISTROS NO PROCESSO DA EVOLUÇÃO SOCIAL E ECONÔMICA: DA ERA PRIMITIVA À ERA DO BLOCKCHAIN
Authors: Cerqueira Anderson José Freitas de , Bispo Jorge de Souza , Dias Filho José Maria
Published: December 2020

As tecnologias emergentes estão provocando fortes impactos econômicos e sociais, impulsionando inovações nos relacionamentos interpessoais, modelos de negócios, produtos, serviços, estratégias, medidas de desempenho e controle dos processos de gestão. Uma dessas tecnologias que vem chamando a atenção de estudiosos cada vez mais é o blockchain. No entanto, essa plataforma tecnológica traduz o papel da Contabilidade, na sua forma mais rudimentar, que é a manutenção de registros (recordkeeping). Nesse contexto, o objetivo deste estudo é demonstrar a evolução social e econômica da escrituração contábil, desde o registro histórico (recordkeeping) rudimentar até o registro histórico criptografado na nuvem por meio do blockchain. O método de pesquisa adotado é o hipotético-dedutivo e a abordagem da pesquisa realizada é qualitativa com suporte bibliográfico. O registro é o primeiro fragmento contábil na história da humanidade, sendo utilizado até o aparecimento das partidas dobradas no início do século 13. O seu uso colaborou, juntamente com outras instituições, para o desenvolvimento econômico e social, fortalecendo o sentimento de confiança nas transações impessoais. Foi identificado que o blockchain, salientado neste artigo como uma tecnologia avançada de manutenção de registros, possui uma perspectiva bastante positiva para contribuir no desenvolvimento econômico e social.
A Multi-Attribute Assisted Performance Deduction and Related Value in Triple Helix Innovation Networks
Authors: Yao Honxing , Antwi Henry Asante , Ankomah-Asare Evans Takyi
Published: December 2020

Typically, Triple Helix relations, between, Higher Education Institutions, Governments and Industry(s) are inferred from patents and research output. Systemic determination of the relationship is because of observations over a period. It is, however, possible to analyze this relation from a system present from the word-go. This then allows for the interaction to be analyzed on the basis of performance and logically gains for participation by all the agents. Several models have been proposed to deduce the Triple Helix Relation and these hold. This paper has however introduced a new dimension to the analysis, by viewing participation from an investor point of view with decision making being of a complex and deductive nature based on the performance of higher education systems or institutions. The TOPSIS supported performance deductions helps synthesis decision solutions that facilitates value determination of performance and its resultant impact on investment gains. Possible future implications for this, are also provided
The Odd Log-Logistic Poisson Inverse Rayleigh Distribution: Statistical Properties and Applications
Authors: Elbatal Ibrahim
Published: December 2020

In this work, a new extension of the Inverse Rayleigh model is proposed and studied. We derive some of its fundamental properties. We assess the performance of the maximum likelihood estimators via a simulation study. The importance of the new model is shown via two applications to real data sets. The new model is better fit than other important competitive models based on two real data sets.
A New Probability Distribution Family Arising from Truncated Power Lomax Distribution with Application to Weibull Model
Authors: Hassan Amal , Sabry Mohamed , Elsehetry Ahmed
Published: December 2020

The truncated distributions have been widely studied, mainly in life-testing and reliability analysis.  In this paper, we introduce a new right truncated generator related to power Lomax distribution, referred to right truncated power Lomax--G family. The proposed family is a generalization of recently [0, 1] truncated Lomax-G family. Statistical properties like; moments, moment generating function, probability weighted moments, quantile function, mean deviation, order statistics and Rényi entropy are derived. Five new sub-models from the truncated family are presented. Maximum likelihood estimation is investigated and simulation issues are discussed for truncated power Lomax Weibull model as particular case from the family. The flexibility of the truncated power Lomax Weibull is assessed by applying it to a real data set. The application indicates that the truncated power Lomax Weibull distribution model can give better fits than other well-known lifetime distributions.
Dynamic analysis of serum Ca-125 levels during neoadjuvant chemotherapy in patients with advanced epithelial ovarian cancer: a retrospective study
Authors: Dharmarajan Adarsh , Remya A. , Krishnan Aswathi
Published: December 2020

Background: Assessment of CA-125 kinetics was commonly used as a tool for tumor response to chemotherapy in ovarian cancer patients. The study aimed to determine any logarithmic/linear relationship between pre-chemotherapy and pre-operative CA-125 levels in ovarian cancer.Methods: Total 52 patients who underwent neoadjuvant chemotherapy (NACT) followed by interval cytoreductive surgery were included. CA-125 levels before starting chemotherapy, during chemotherapy and the preoperative value, with the date of measurement recorded. Cox’s proportional hazards regression was used to evaluate univariate and independent multivariable association with the effect of clinical, pathological and CA-125 kinetic parameters on outcome endpoints.  Results: The study couldn’t establish any relationship in logarithmic fall of CA-125 values among ovarian cancers as a result of neo-adjuvant chemotherapy. The disease-free survival among the patients was 12.2 months.Conclusions: There is an inverse relationship between serum CA-125 levels and survival in ovarian cancer. NACT resulted in adequate fall of CA-125 levels in most of the patients, but the rate of fall was not predictive of prognosis.
To compare the diagnostic accuracy of hysteroscopy with transvaginal sonography in detection of endometrial polyp and endometrial hyperplasia in peri and postmenopausal women with abnormal uterine bleeding
Authors: Sharma Surbhi , Sharma Anoop
Published: December 2020

Abnormal uterine bleeding is the most common health problem encountered by women. AUB is a common gynaecological complaint and it may involve females at any age group. 33% of women referred to gynaecology clinics have AUB and the figure rises to 69% in premenopausal and postmenopausal women. Abnormal uterine bleeding accounts for two thirds of all hysterectomies.

The present study was prospective cross sectional study conducted in the Department of Obstetrics and Gynaecology, Kamla Nehru State Hospital for Mother &Child Indira Gandhi Medical College Shimla for period of one year w.e.f 1st May 2018 to 30th April 2019. The study was started after hospital ethical committee approval.76 patients peri and post menopausal women were enrolled in the study after taking written consent).A detailed history, general and systemic examination was done. All patients underwent transvaginal sonography followed by hysteroscopy and further management was done according to the abnormality detected.

Hyperplasia on TVS was present in 15 study subjects i.e 19.7% (14 perimenopausal one postmenopausal). 13 subjects i.e 17.1% on hysteroscopy showed hyperplasia further on histopathology hyperplasia was confirmed in 15 subjects i.e 19.7% (14 had simple hyperplasia one had complex hyperplasia with atypia). On TVS endometrial polyp was seen in 22 subjects i.e 28.9% (18 perimenopausal four post menopausal) Hysteroscopy showed that 27 subjects i.e 35.5% had endometrial polyp (23 peri menopausal four postmenopausal). Further on histopathology endometrial polyp was confirmed to be present in 26 subjects i.e 34.2%. Sensitivity Specificity PPV NPV of Transvaginal sonography versus hysteroscopy for endometrial polyp was 81.5% 100% 100%, 88.6% repectively. For endometrial hyperplasia Sensitivity Specificiy PPV NPV was 100% 96.3% 86.9% 100% respectively.

Abnormal uterine bleeding is a problem which women in perimenopausal and postmenopausal period frequently encounter. Of all investigations, TVS is quick, simple, painless, least invasive, less expensive and readily available procedure. Hysteroscopy not only allows direct visual observation of pathology but also provides a means to sample the site, most likely to yield positive results. Hence, it should be made an essential part of diagnostic workup of abnormal uterine bleeding.