bluuebunny/crossref_metadata_2025 huggingface dataset:
Recombinant 60-kDa heat shock protein from Paracoccidioides brasiliensis induces the death of mouse lymphocytes in a mechanism dependent on Toll-like receptor 4 and tumor necrosis factor
Authors: Souza Igor Emiliano L. , Fernandes Fabrício F. , Panunto-Castelo Ademilson
Published: March 2024

Paracoccidioides fungi are thermodimorphic microorganisms that cause paracoccidioidomycosis (PCM), an autochthonous disease from Latin America, with most cases in Brazil. Humans become infected by inhaling conidia or mycelial fragments that transform into yeast at body temperature. These fungi cause chronic-granulomatous inflammation, which may promote fibrosis and parenchyma destruction in the lungs. In response to stress imposed by the host, fungi Paracoccidioides spp. increase the expression of heat shock proteins (HSP), which protect them by sustaining cellular proteostasis. Our group has studied the role of HSP60 in PCM, and previous data show that the recombinant HSP60 (rHSP60) has a deleterious effect when used in a single dose as therapy for experimental PCM. Here, we investigated the mechanism by which rHSP60 could worsen the disease. We found that rHSP60 caused the viability loss of splenic or lymph node cells from both immunized and non-immunized mice, including in splenic T lymphocytes under polyclonal stimulation with concanavalin A, probably by undergoing apoptosis. Among analyzed splenic cells, lymphocytes were indeed the main cells to die. When we investigated the death mechanisms, remarkably, we found that there was no viability loss in rHSP60-stimulated splenic cells from mice deficient in Toll-like receptor 4, TRIF adapter protein, and TNF receptor 1(TNFR1), as well as rHSP60-stimulated WT cells incubated with anti-TNF antibody. Besides, caspase-8 inhibitor IETD-CHO blocked the rHSP60 effect on splenic cells, suggesting that rHSP60 induces the extrinsic apoptosis pathway dependent on signaling via TLR4/TRIF and TNFR1.
Dogs’ social susceptibility is differentially affected by various dog–Human interactions. A study on family dogs, former shelter dogs and therapy dogs
Authors: Kis Anna , Tóth Katinka , Langner Lívia , Topál József
Published: March 2024

When pre-treated with social stimuli prior to testing, dogs are more susceptible to human influence in a food preference task. This means, after a positive social interaction they are more willing to choose the smaller amount of food indicated by the human, as opposed to their baseline preference for the bigger amount. In the current study we investigate if and how various forms of social interaction modulate choices in the same social susceptibility task, testing dogs with varying early life history (pet dogs, therapy dogs, former shelter dogs). In line with previous studies, dogs in general were found to be susceptible to human influence as reflected in the reduced number of “bigger” choices in the human influence, compared to baseline, trials. This was true not only for pet dogs with a normal life history, but also for dogs adopted from a shelter. Therapy dogs, however, did not uniformly change their preference for the bigger quantity of food in the human influence trials; they only did so if prior to testing they had been pre-treated with social stimuli by their owner (but not by a stranger). Pet dogs were also more influenced after pre-treatment with social stimuli by their owner compared to ignoring and separation; however after pre-treatment by a stranger their behaviour did not differ from ignoring and separation. Former shelter dogs on the other hand were equally influenced regardless of pre-treatment by owner versus stranger. In summary these results show that dogs’ social susceptibility is modulated by both interactions immediately preceding the test as well as by long term social experiences.
Accessible luminal interface of bovine rectal organoids generated from cryopreserved biopsy tissues
Authors: Kawasaki Minae , Ambrosini Yoko M.
Published: March 2024

Developing precise species-specific in vitro models that closely resemble in vivo intestinal tissues is essential for advancing our understanding of gastrointestinal physiology and associated diseases. This is especially crucial in examining host-pathogen interactions, particularly in bovines, a known reservoir for microbes and pathogens posing substantial public health threats. This research investigated the viability of producing bovine rectal organoids from cryopreserved tissues. We compared two cryopreservation methods with a traditional technique using fresh tissues, evaluating their effectiveness through growth rates, long-term viability, and comprehensive structural, cellular, and genetic analyses. These assessments utilized phase-contrast imaging, immunofluorescence imaging, and RT-qPCR assays. Additionally, the study developed a sophisticated method for forming a functional epithelial barrier from organoid-derived bovine rectal monolayers, incorporating a wide range of epithelial cells. This methodology employed transepithelial electrical resistance (TEER), parallel artificial membrane permeability assay (Papp), confocal microscopy, and advanced imaging techniques like scanning electron microscopy (SEM) and transmission electron microscopy (TEM). Our findings decisively show that bovine rectal organoids can be effectively generated from cryopreserved biopsy tissues. Moreover, we formulated a robust and optimized protocol for creating functional rectal monolayers from these organoids. This significant progress is particularly relevant given the susceptibility of the bovine rectum to various enteric pathogens of public health concern, marking a vital step forward in veterinary and biomedical research. The creation of accurate species specific in vitro models that faithfully mimic in vivo intestinal tissues is critical for enhancing our understanding of gut physiology and related pathologies. This is particularly relevant in studying the interactions between hosts and microbes or pathogens with significant public health risks where bovine can be the major reservoir.
Virus specificity and nucleoporin requirements for MX2 activity are affected by GTPase function and capsid-CypA interactions
Authors: Layish Bailey , Goli Ram , Flick Haley , Huang Szu-Wei , Zhang Robert Z. , Kvaratskhelia Mamuka , Kane Melissa
Published: March 2024

Human myxovirus resistance 2 (MX2/MXB) is an interferon-induced GTPase that inhibits human immunodeficiency virus-1 (HIV-1) infection by preventing nuclear import of the viral preintegration complex. The HIV-1 capsid (CA) is the major viral determinant for sensitivity to MX2, and complex interactions between MX2, CA, nucleoporins (Nups), cyclophilin A (CypA), and other cellular proteins influence the outcome of viral infection. To explore the interactions between MX2, the viral CA, and CypA, we utilized a CRISPR-Cas9/AAV approach to generate CypA knock-out cell lines as well as cells that express CypA from its endogenous locus, but with specific point mutations that would abrogate CA binding but should not affect enzymatic activity or cellular function. We found that infection of CypA knock-out and point mutant cell lines with wild-type HIV-1 and CA mutants recapitulated the phenotypes observed upon cyclosporine A (CsA) addition, indicating that effects of CsA treatment are the direct result of blocking CA-CypA interactions and are therefore independent from potential interactions between CypA and MX2 or other cellular proteins. Notably, abrogation of GTP hydrolysis by MX2 conferred enhanced antiviral activity when CA-CypA interactions were abolished, and this effect was not mediated by the CA-binding residues in the GTPase domain, or by phosphorylation of MX2 at position T151. We additionally found that elimination of GTPase activity also altered the Nup requirements for MX2 activity. Our data demonstrate that the antiviral activity of MX2 is affected by CypA-CA interactions in a virus-specific and GTPase activity-dependent manner. These findings further highlight the importance of the GTPase domain of MX2 in regulation of substrate specificity and interaction with nucleocytoplasmic trafficking pathways.
Ebola virus disease sequelae and viral persistence in animal models: Implications for the future
Authors: Durant Olivia , Marzi Andrea
Published: March 2024

Ebola virus disease (EVD), caused by infection with Ebola virus, results in severe, acute illness with a high mortality rate. As the incidence of outbreaks of EVD increases and with the development and approval of medical countermeasures (MCMs) against the acute disease, late phases of EVD, including sequelae, recrudescence, and viral persistence, are occuring more frequently and are now a focus of ongoing research. Existing animal disease models recapitulate acute EVD but are not suitable to investigate the mechanisms of these late disease phenomena. Although there are challenges in establishing such a late disease model, the filovirus research community has begun to call for the development of an EBOV persistence model to address late disease concerns. Ultimately, this will aid the development of MCMs against late disease and benefit survivors of future EVD and filovirus outbreaks.
Credits, Social Policies and Consumption In Buenos Aires City
Authors: Chahbenderian Florencia
Published: March 2024

At the turn of the twenty-first century, social policies became one of the fundamental instruments on which the current capital accumulation regime is based, given their massive nature and global character. So-called conditional cash transfer programs (CCTs) were a milestone in this direction. The objective of this article is to study the consumption practices – the what and how – that CCTs impose on their recipients and the latter’s relationship with credit in Buenos Aires City. The qualitative methodology is based on documentary analysis and semistructured interviews with CCT recipients and public servants. The implications for social policies can be summarised as: (a) re thinking the links between the market and the State, as these regulations involve politics of the body/emotions; and (b) deepening the connections between social policies (in the form of CCTs), consumption, and credit.
New Classical Relativistic Theory of a Charged Particle in an Electric Field
Authors: Karapetyan Grigori.G.
Published: March 2024

A new relativistic theory of the classical motion of a charged particle in an electric field has been developed. The resulting equations characterize the kinematic and dynamic features of particle motion, demonstrating peculiar behavior in areas with high attractive potentials. This changes the existing paradigm for the interaction of charge with an electric field, entailing profound consequences. The new theory converges with the conventional theory of electricity under conditions of low potentials and nonrelativistic particle velocities. The possibility of experimental verification of the new theory is discussed.
Carboxypeptidase A3 in the structure of the protease phenotype of mast cells: cytophysiological aspects
Authors: Atyakshin D. A. , Kostin A. A. , Trotsenko I. D. , Shishkina V. V. , Timann M. , Bukhvalov I. B. , Volodkin A. V. , Ignatyuk M. A.
Published: March 2024

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Full-exome and transcriptional profiling of a tissue sample of neuroendocrine lung cancer in order to clarify the diagnosis and select options for antitumor therapy
Authors: Luppov D. V. , Moiseev A. A. , Buzdin A. A.
Published: March 2024

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Transaxillary endoscopic thyroidectomy in the treatment of differentiated thyroid cancer
Authors: Glushkov P. S. , Azimov R. H. , Shemyatovsky K. A. , Khusanov Sh. S. , Sidorova A. S. , Karneev N. A. , Levikin K. E. , Gorsky V. A.
Published: March 2024

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Gender-specific manifestations of endocrine function of mesenchymal tissues in obese children with genetic polymorphism rs328 of the lipoprotein lipase gene
Authors: Davydov V. V. , Tumanyan G. Ts. , Teplyakova E. D. , Shestopalov A. V.
Published: March 2024

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Features of clinical and laboratory-instrumental manifestations of pheochromocytoma. Own data
Authors: Lugovskaya A. Yu. , Katz M. V. , Ilovaiskaya I. A.
Published: March 2024

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Neuroendocrine tumors of the bronchopulmonary system and thymus
Authors: Mamedov I. Ya.o. , Feydorov I. Yu.
Published: March 2024

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Hippel-Lindau syndrome: description of clinical cases
Authors: Nikolaeva D. S. , Suinalieva A. N. , Shaidullina M. R. , Sozaeva L. S. , Kareva M. A.
Published: March 2024

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The immune landscape of adrenocortical cancer: analysis and prognostic significance of tumor-infiltrating immune cells in various morphological variants
Authors: Pachuashvili N. V. , Porubaeva E. E. , Urusova L. S.
Published: March 2024

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A case of pancreatic glans insulinoma with low C-peptide level
Authors: Pogolsha E. V. , Tsoi U. A. , Belousova L. V. , Grineva E. N.
Published: March 2024

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Analysis of the steroidreference factor of the graft-versushost reaction in allogeneic transplantation in children with hemoblastoses
Authors: Sidorova N. V. , Semochkin S. V. , Rumyantsev S. A.
Published: March 2024

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The role of tryptophan metabolites in the development of autoreactivity
Authors: Shatova O. P. , Yagodkina E. M. , Kaidoshko S. S. , Zabolotneva A. A. , Shestopalov A. V.
Published: March 2024

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In memory of Bubnov Alexander Nikolaevich (26.07.1939 — 18.09.2023)
Authors: Chernikov R. A.
Published: March 2024

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The challenge of proving causality in lawsuits for pesticide contamination
Authors: Souza Beatriz Carvalho de , Vasconcelos Vitor Vieira , Nascimento Victor Fernandez
Published: March 2024

Despite the long history of research into the risks caused by the extensive use of pesticides to the environment and human health, it is still challenging to identify the causal link between the event and the damage, that is, proving that a specific product, on that occasion, caused that damage. The present study aims to analyze this difficulty in liability suits for pesticide contamination, as this evidence is essential for the lawsuit to be successful. Authors such as Bombardi (2017) and Pignati et al. (2017), among others, contributed to the writing. Jurisprudential research was carried out in the states of Mato Grosso, São Paulo, Pernambuco, and Paraná, as well as interviews with judicial experts and a public labor prosecutor. In jurisprudence, it is clear that damages to human health and crops mainly trigger the judiciary which, in approximately half of the decisions, the causal link was not established, with the main obstacles being the failure to prove the relationship between pesticides and diseases, and pesticide drift to locations other than where it was applied. During the interviews, the complexity of these products was reported, as they are only identified under particular temporal, spatial, and quantity conditions. The combination of these analyses demonstrates the need for investment in inspection and monitoring policies, as well as laboratory structures, so the judiciary can be more effective in its actions, in addition to reviewing the pesticides allowed in Brazil and their maximum tolerated quantities.
Transesterification of biodiesel from kapok seed oil (ceiba pentandra) using a natural heterogeneous katalyst (rice husk activation)
Authors: . Marhaini , Sri Yusmartini Eka , Fernianti Dewi , Okka Widhanny Larasati
Published: March 2024

Biodiesel as a renewable energy source can be produced by a chemical reaction between vegetable oil or animal fat and short-chain alcohol such as methanol, ethanol or buthanol and is supported by a catalyst. This process is called transesterification. From an environmental point of view, the use of biodiesel has several advantages such as reducing carbon dioxide emissions, being non-toxic and biodegradable. Kapok seed oil has potential for exploitation, particularly as a raw material for the manufacture of biofuel. Kapok seeds (Ceiba pentandra) have the potential to be used as a feedstock for biodiesel because their oil content is quite high, around 18-25% oil. The controlled combustion of rice husks produces ash containing high purity amorphous silica. Amorphous silica can be obtained from RHA (rice husk ash) when rice husk is burned at a temperature of 700°C, and it is transformed into crystalline silica when burned at a temperature above 850 °C. This silica has many applications as a filler, adsorbent, catalyst support, star gel component and source for the production of premium silicon and its compounds. The aim of the research is to determine the transisterification process of biodiesel from kapok (Ceiba pentandra) seed oil. using a natural heterogeneous catalyst in It is an activated rice husk. The method used was the preparation of kapok seed samples and the extraction of sokhlet. Determination of free fatty acids (FFA) in kapok seed oil, activation of rice husk, manufacturing of biodiesel from kapok seed with addition of rice husk H2SO4 as catalyst. The characteristics of the biodiesel produced are Density: 859.88572 kg/m3 (SNI: 7182:2015) = 850-890 kg/m3), Viscosity: 2.45824 cSt (SNI: 7182:2015) = 2.3 – 6, 0 cSt, Calorific value: 7,374.5322 cal/g (SNI: 7182; 2015) = 7,100 -11,000 cal/ g, Devil's number: 48 (ASTM: D6751) = 47. Meanwhile, GC-MS with the highest values at all reaction times, namely Hexadecanoic acid, methyl ester (C17H34O2), methyl tetradecanoate (C15H30O2) and 9 - Octadecenoic acid (Z), methyl ester (C19H36O2) . The functional group found in kapok seeds is –OH.
Profile of adult patients hospitalized for asthma exacerbation
Authors: Kambouche Faouzia , Medjane Rabia
Published: March 2024

A variable proportion of patients presenting to the emergency department (ED) with acute asthma require admission to hospital. Previous studies have identified select factors associated with admission following ED presentation .However, patients hospitalized for AEs are highly heterogeneous and remain largely unexplored.This review discusses current aspects on the pathogenesis and pathophysiology of acute severe asthma exacerbations and provides the current perspectives on the management of acute severe asthma attacks in the emergency department and the intensive care unit.
Incidence of healthcare-associated infections in intensive care of the emergency department of Oran in Algeria
Authors: Benbernou Soumia , Ghoumari Nabil , Kambouche Fouzia , Kouadria Rabah
Published: March 2024

Introduction. Healthcare-associated infections (HAIs) are a serious problem of modern medicine. Patients hospitalized in intensive care units (ICUs) develop HAI significantly more often than patients in other hospital units.
Materials and Methods.
We carried out a retrospective study spread over 2 years from January 2019 to December 2021. Data were collected on a form established with the microbiology department of the the University Hospital center of Oran, sites of nosocomial infection, germs involved, antibiotic resistance.
Results: 886 samples were collected during the study period, of which 660 were positive. 270 patients were admitted to hospital during this period. The average age of our patients was 39.4 years. The most frequently isolated bacteria were Klebsiella pneumoniae ,Acinetobacter baumannii ,Staphylococcus aureus ,and Escherichia coli .
Conclusion Infection control based on incidence rate for each type of infection is necessary in ICU to assess the epidemiological situation.
Theoretical analysis of the quartic autocatalytic reaction of a thermally radiative ternary hybrid nanofluid in a stratified porous medium
Authors: M .Ajayi Tunde , W. Ogunsola Amos , A. Ajala Olusegun
Published: March 2024

Quartic autocatalytic form of chemical reaction has valuable interference in catalysis, manufacturing of ceramics, and production of polymers. Motivated by this, the present work examined the quartic autocalytic chemical reaction of an hybrid nanofluid in the presence of thermal stratification, radiation, porosity. Similarity transformation method was employed to convert the governing equations into ordinary differential equations. The existence and uniqueness of a solution was examined, and numerical solution thereafter obtained. Results obtained were shown in figures.
Studies Studies on the phytochemicals of clove and their biological activities
Authors: Hema Krishna R
Published: March 2024

Cloves are a fragrant spice made from the dried flowers of the clove tree. In the past, spices used to be worth their weight in gold, and cloves were no exception. Today, cloves remain a popular spice that gives many dishes subtly sweet warmth. A drop of clove oil is 400 times more powerful as an anti-oxidant than wolf berries or blueberries. Cloves contain a lot of manganese, a mineral that helps your body manage the enzymes that help repair your bones and make hormones. Manganese can also act as an antioxidant that protects your body from harmful free radicals (unstable atoms that cause cell damage). Cloves are a fragrant, dense spice that can be added to both savory dishes (such as curries) and sweet desserts (such as pumpkin pie). They're full of powerful nutrients that help protect your cells from damage. Some natural compounds in cloves interfere with medicines or cause side effects that can be life-threatening. So, it's safest to only cook or bake with cloves and enjoy this spice's health benefits that way. Clove is utilized in cosmetics, medicine, gastronomy, and agriculture due to its abundance of bioactive components such as gallic acid, flavonoids, eugenol acetate, and eugenol. Clove essential oil has been revealed to have antibacterial, antinociceptive, antibacterial activities, antifungal, and anticancerous qualities. Anti-inflammatory chemicals, including eugenol and flavonoids, are found in clove that help decrease inflammation and alleviate pain. The anti-inflammatory and analgesic qualities of clove oil have made it a popular natural cure for toothaches and gum discomfort. Due to its therapeutic potential, it has been used as a bioactive ingredient in coating fresh fruits and vegetables. This research article outlines the potential food processing applications of clove essential oil. The chemical structures of components, bioactive properties, and medicinal potential of clove essential oil, including phytochemical importance in food, have also been thoroughly addressed.
Mathematical modelling and analysis of Kidnapping dynamics
Authors: Usaini Salisu , Rabiu Sani , Shitu Hassan Adamu
Published: March 2024

The problem of kidnapping as a social menace to a society is increasing in some African countries such as Nigeria. We therefore proposed a new deterministic mathematical model for the dynamics of Kidnapping in a community. This menace is considered like a two strains communicable disease with kidnapping propagation mission by kidnappers as one strain and adoption mission for kidnapped victims as the other strain to assess the impact of super-infection. The model exhibits four equilibrium points each of which is unique and asymptotically stable both locally and globally under certain conditions. We obtain the kidnapping propagation number  where  is the propagation number associated with strain . Another important threshold parameters associated with respective strains 1 and 2 are  and . Indeed, we show that at most one strain invades the population if one of these parameters is less than unity. while the two strains coexist at endemic state when both  and  are greater than unity. The global stability results of the model equilibria are established by numerical simulations. This simulations results indicate that the super-infection destabilizes the coexistence equilibrium.
Investigation of some useful chemical parameters in Shea tree (Vitelaria paradoxa) nut wastewater collected after extraction of the butter: prospects of Shea butter waste valorization
Authors: E. Amofa , S. A. Abagale , O. Awo , I. Sackey , F.K Abagale , K.S Twumasi
Published: March 2024

Shea butter is extracted the nut of Vitellaria paradoxa for both domestic and commercial purposes. Growing extraction and utilization of the butter especially in pharmaceutical, food and cosmetics industries result in large shea butter extraction with resultant large volumes of waste product of unknown content. Analyses of the wastewater/byproduct was carried out to review possibilities of its value addition in production of new products, or otherwise appropriate disposal. Therefore, Atomic Absorption Spectroscopy, physicochemical, and phytochemical screening methods, and extraction were used in the current study to assess antioxidant activity, BOD, calcium, iron, magnesium, lead, nickel, zinc, copper, and phytochemical content of samples of the material from Northern Ghana. The amount of residual oil was also determined. The BOD ranged from 168.00±0.00 to 86.25±6.25 mg O2/kg; Levels of magnesium in the samples ranged from 16.65 - 206.65 mg/kg, calcium from 4.72 - 19.60 mg/kg, iron was 7.75 - 14.0 mg/kg, copper from 0.02 - 0.08 mg/kg, lead from 0.33 - 1.22 mg/kg, nickel from 0.04 - 0.23 mg/kg and zinc from 3.36 - 5.80 mg/kg. Secondary metabolites present included alkaloids, phenolic, saponins, tannins and flavonoids. while residual oil extracted from the sample was between 14.67-6.46 % of the material. Mean pH was 5.95±0.05 - 6.10±0.005, and the mean temperature of the samples ranged from 24.00±0.05 to 25.25±0.05 oC at the time of analyses. From the findings the material has good and diverse content and could be used in cosmetics, pharmaceutical products or organic manure. Otherwise it should be disposed appropriately to safeguard environmental and water pollution.
Determination of the mechanism of sorption of Cu2+ ions to hydrolyzed fibroin
Authors: Eshchanov Khushnudbek
Published: March 2024

We were able to obtain hydrolyzed fibroin with sorbing properties from fibrous silk waste. We determined the mechanism of sorption of Cu2+ ions into hydrolyzed fibroin using the Dubinin-Radushkevich isotherm. Physical sorption of Cu2+ ions to hydrolyzed fibroin has been shown to be predominant. However, it has been observed that the colour of hydrolyzed fibroin, which sorbs Cu2+ ions, changes to yellow over time. Analysis of the yellowed sample by IR spectroscopy showed that Cu2+ ions formed a coordinate bond with the hydrolyzed fibroin.Â Â
Effect of acid and ionic strength on the kinetics of electron transfer reaction of n-(2-hydroxy-ethyl) ethylenediamine-n, nâ€™, nâ€™-triacetatocobaltate (ii) complex with hypochlorite ion in aqueous acidic medium
Authors: Ahmed Y. , D.Onu A. , O.Idris S. , S.Iliyasu S. , B.Abiti Y.
Published: March 2024

The influence of acid and ionic strength on the rate of electron transfer reaction of N-(2-hydroxy-ethyl)ethylenediamine-N,Nâ€™,Nâ€™-triacetatocobaltate(II)(hereafter, complex with Hypochlorite ion in aqueous nitric acid medium have been studied at I = 0.2 mol dm-3(NaNO3), [H+] = 1 Ã— 10-2 mol dm-3, , T = 300 Â± 1 K and Î»max = 525 nm. Stoichiometric study showed 1:1 `mole ratio. The rate law derived from the kinetic study under pseudo first order condition is . The rate constant of reaction, Â varies inversely with acid concentration, [H+]. The overall rate law is therefore represented as: . The reaction displayed positive salt effect which suggests the activated complex was made up of similar charged species. The reaction was catalysed by addition of formate, HCOO- and potassium, K+ ions and the Michaelis-Mentenâ€™s plot gave zero intercept indicating the absence of intermediate complex. A reaction mechanism via an outer-sphere pathway is proposed for this reaction.Â Â
Evaluation of retardant property of green hair growth retardant formula
Authors: Ogboji Joel
Published: March 2024

Background: The relevance of depilatory creams has appreciated significantly in recent time and their demand is on the increase. However most commercial depilatory creams contain chemicals with questionable health safety. These synthetic chemicals cause scaring, itching and burns on the skin.Objectives: The study attempted to formulate green hair growth retarding cream, testing the formula for phytochemicals, hair growth retarding property and toxicity.Methods: the cream was formulated from extracts of Tumeric (Curcuma longa), Aloe vera (Aloe barbadensis miller), Guava (Psidium guajava) and Neem (Azadirachta indica), evaluated for its phytochemical constituents and tested for its hair growth retardant property and toxicity on mice.Results: The results show the presence of phytochemicals like tannins, phenols, flavonoids, terpeniods, alkaloids, volatile oil, anthroquinone, glycosides, saponins and a 25% hair growth retarding efficiency on tested mouse, no signs of itching, redness, swelling and topical injuries on the mouse.Conclusion: overall, the research therefore provide convincing evidence of the safety of the formula over the conventional ones and also exhibit satisfactory hair regrowth retarding property.Â Â
Comparison studies for the removal of a basic dye from aqueous solution using coffee residues and waste tea
Authors: Benhachem Fatima-Zahra , Attar Tarik
Published: March 2024

Dyes are one of the most important industrial pollutants, especially in textile industries. The coffee residues and wastes tea are food industrial solid wastes, were used as low-cost adsorbents for the removal of methylene blue (MB) dye from aqueous solution. Many methods have been proposed in order to remove color from wastewater among which, adsorption is more acceptable due to the ability for its use in the large scale. The influence of various experimental factors such as contact time, adsorbent dosage, temperature and pH of dye solution was investigated. Two simplified kinetic models including pseudo-first-order and pseudo-second-order equation were selected to follow the adsorption processes. It was observed that chemisorptions pseudo-second order kinetic model described the sorption process with high coefficients of determination (R2) better than pseudo-first order kinetic model. Thermodynamic parameters such as Î”GÂ°, Î”HÂ°, and Î”SÂ° were calculated the results of this parameteres indicated that the adsorption of methylene blue onto residues coffee and waste tea were spontaneous process.Â Â
Parametric identification method for an absorption air conditioning parabolic trough collector solar plant
Authors: Díaz-Salgado Jorge , García - López S. , R. Galindo - Luna Y. , J. Romero R.
Published: March 2024

In this work is established a parametric identification method for an absorption air conditioning solar plant. A scaled thermal plant, consisting of a thermal capacitor and a flow line that acts as a capacitor and thermal energy radiator is used. As the mathematical model of the scaled plant is structurally identical to that of the solar plant the first is used to determine the methodology that can be used later for the identification of the PTC solar plant. Parametric identification is a necessary step that allows to determine the unknown parameters of the mathematical model of any solar/thermal plant. This model then can be used to analyze the plant characteristics and design an appropriate control algorithm. Although the system model is nonlin-ear it can be expressed in the form of a linear regressor in the parameters. This permits to use the least squares method as the identification method. The method is applied to the thermal plant to identify the useful form that the covariance matrix and excitation signals should have to ensure that when applied to the solar plant its unknown parameters can be properly estimated. Once the solar plant parameters are properly estimated model can be used to analyze and simulate the operation of the ab-sorption air conditioning system.
Association of environmental exposure to heavy met-als with chronic kidney disease (CKD) in patients from White Nile province, Sudan
Authors: M.E Elzin , E .H Mohamed , M I Abdelgadir
Published: March 2024

This research was focused on assessment of chronic kidney disease (CKD), due to the contamination of water, in White Nile Province, Sudan with heavy metals, agrochemicals, hard water, ionicity, and climate changes. Nevertheless, the levels of any of the pollutants or conditions reported in this water are inconsistent not correlated with the prevalence of the disease and are too low to cause (CKD). The most common cause of chronic kidney disease (CKD) among all groups was diabetes mellitus (46.50%); followed by hypertension (46.50%); chronic glomerulonephritis (7.64), while other causes account for only (9.55%). The highest prevalence of CKD was recorded in Eld – Duiem, followed by Allahamed localities, with a percentage of (22.9% and 17.8%), respectively. The highest prevalence of the cases was recorded in patients of the range age of 31-50 years, followed by patients from the group 51-70 years old, and least in the group of 71-90 years old. Famers recorded a frequency of (20.38%) and sponsors recorded a frequency of (17.20%), while, among groups of other occupation a high frequency of (42%) was recorded. The level of education reflected a high frequency of CKD among the individuals of primary education, followed by individuals of secondary education, while the lowest frequency was recorded among illiterates. People living in red brick building, recorded the highest number of CKD patients (142 patients) while only (5 patients) who live in wool building were recorded. On the other hand, high prevalence of CKD (113 patients) was recorded in groups who do not take herbs, while the more patients (44) were recorded among individuals who take herbs. All results showed significance of (P ≤ 0. 05).
Quasi-linear correlation between shear and young’s moduli in some polycrystalline ceramics
Authors: Daoud Salah , Saini Pawan-Kumar , Rekab-Djabri Hamza
Published: March 2024

This work aims to investigate the correlation between the shear modulus and the Young’s modulus of some pore-free polycrystalline ceram-ics. Our study shows that the shear modulus correlates quasi-linearly with the Young’s modulus. The best fit was obtained using the linear model. The fit of the shear modulus G as a function of the Young modulus E obeys this linear expression: G = 0.43E - 7.7 (where both G and E are expressed in GPa). The coefficient of the correlation was found at around 0.994. Our expression was used to predict the shear modulus G of some other polycrystalline ceramics, especially: Dy2O3, Er2O3, and Y2O3 materials, which are estimated at around 65.6, 72.4, and 51.8 GPa, respectively. We attempt also to estimate the Vickers hardness of our materials of interest using an empirical expression of the literature. Unfortunately our predicted results are larger than those reported previously in the literature.
Continuidade do trabalho, com novas ideias
Authors: Ribeiro Jonathan
Published: March 2024

Ser editor do JBCOMS, seja como editor-chefe ou editor associado, é um desafio e um privilégio para qualquer membro do CBCTBMF. Após dois anos de aprendizado ao lado do Dr. Sylvio de Moraes, darei continuidade ao trabalho realizado, tendo como foco o crescimento da nossa revista.
Tratamento de fratura complexa dos terços médio e superior da face: relato de caso
Authors: Louzada Guilherme Pivatto , Silva Guilherme Zanovelli , Sousa Gines Alves de , Ferreira Laura Maria Oliveira , Cerqueira Ana Beatriz Goettnauer de
Published: March 2024

Introdução: O manejo das fraturas faciais associadas a traumatismo cranioencefálico (TCE) grave necessita de uma abordagem precoce para estabilizar o paciente e permitir um prognóstico favorável. Objetivo: Relatar o caso clínico de um paciente do sexo masculino, 30 anos de idade, vítima de colisão motociclística, com Escala de Coma de Glasgow (ECG) em 12 pontos. Relato de caso: Ao exame clínico, verificou-se blefarohematoma bilateral, afundamento em osso frontal e ausência de fístula liquórica. Ao exame tomográfico, constatou-se fratura das paredes anterior e posterior do seio frontal, fratura de maxila Le Fort tipo II, blow out do lado direito, além de hematoma subdural na região frontal. Após avaliação pela equipe de Neurocirurgia, foi indicada uma abordagem emergencial para realizar o tratamento do sangramento intracraniano. A abordagem conjunta da equipe de Cirurgia Bucomaxilofacial possibilitou a fixação da fratura de parede anterior do seio frontal e tratamento das demais fraturas de terço médio em um mesmo tempo cirúrgico. Considerações Finais: O presente relato de caso demonstrou que a intervenção multidisciplinar em caráter emergencial é uma abordagem viável e traz benefício em longo prazo. A obliteração do ducto nasofrontal nesses casos de fratura de parede posterior do seio frontal é indicada, evoluindo sem complicações no pós-operatório de 14 meses.
Carta do Presidente
Authors: Germano Adriano Rocha
Published: March 2024

Caros colegas membros do CBCTBMF, é com grande satisfação que anuncio o sucesso de vários projetos desenvolvidos pela nossa gestão em tão poucos meses. O pós-pandemia também trouxe enormes desafios estruturais para os eventos científicos, e para nós do CBCTBMF não foi diferente. Os eventos regionais de 2023 (SULBRABUCO, ENNEC e COPAC) alcançaram seus objetivos não só de público, mas de qualidade científica e de participação expressiva dos nossos parceiros comerciais. O ambiente é de satisfação; porém, estamos convictos de que podemos sempre avançar. O CBCTBMF implementou o PAER (Programa de Apoio ao Ensino das Residências) e, atualmente, tem se preocupado em garantir ao associado adimplente sua inserção no programa de educação continuada organizado pelos capítulos, com palestras inovadoras que contribuem para seu desempenho profissional.
Reunião do JBCOMS durante o 16º COPAC
Authors: Ribeiro Jonathan
Published: March 2024

A próxima Reunião do Jornal Brasileiro de Cirurgia e Traumatologia Buco-Maxilo-Facial (JBCOMS) está agendada para ocorrer durante o 16º Congresso Paulista de Cirurgia e Traumatologia Buco-Maxilo-Facial (COPAC), que acontecerá entre os dias 23 e 25 de novembro de 2023, no Centro de Convenções Rebouças, localizado na cidade de São Paulo.
Uma entrevista com Liogi Iwaki Filho
Authors: Iwaki Filho Liogi , Pittella Renata
Published: March 2024

Entrevista com Dr. Liogi Iwaki Filho sobre o Programa de Apoio ao Ensino nas Residências. Doutorado em Diagnóstico Bucal pela Faculdade de Odontologia de Bauru – FOB – USP (Bauru/SP, Brasil). Professor associado da Universidade Estadual de Maringá em Cirurgia e Traumatologia Bucomaxilofacial (Maringá/PR, Brasil). Coordenador da Residência em Cirurgia e Traumatologia Bucomaxilofacial e Professor Efetivo do Programa de Pós-Graduação em Odontologia Integrada da Universidade Estadual de Maringá (Maringá/PR, Brasil).
Perfil epidemiológico dos traumas maxilofaciais de pacientes atendidos em um hospital da Baixada Fluminense
Authors: Cerqueira Ana Beatriz Goettnauer de , Sousa Gines Alves de , Silva Guilherme Zanovelli , Azevedo Antônio Marcos Pantoja de , Louzada Guilherme Pivatto
Published: March 2024

Introdução: O traumatismo facial é considerado um importante problema de saúde pública, devido à crescente prevalência registrada anualmente e, principalmente, pelos danos à saúde das vítimas, como perdas funcionais, deformidades faciais e transtornos emocionais, que causam incapacidade ou afastamento do trabalho por longos períodos. Objetivos: O objetivo deste estudo foi realizar um levantamento epidemiológico e uma avaliação do perfil do atendimento no Hospital Municipalizado Adão Pereira Nunes (HMAPN, Duque de Caxias/RJ), no período de 2017 a 2022. Metodologia: Foi feita uma análise retrospectiva de prontuários de pacientes que realizaram tratamento de urgência/emergência, seguido do acompanhamento ambulatorial no HMAPN. Os dados coletados foram divididos nos seguintes subgrupos: sexo, etiologia, idade, tipo de fratura sofrida pelo paciente, tipo do tratamento realizado e o local de moradia. A partir desses dados, foi criado um banco de dados. Resultados: No total, foram incluídos 1.403 prontuários, e observou-se uma maior prevalência de acidentes de motocicleta (17,17%), seguidos pelas agressões físicas (11,6%), com idade média de 20-30 anos (24,86%), sexo masculino (77,33%), sendo as regiões mandibular (30,57%) e zigomática (24,16%) da face as mais acometidas. Conclusão: Adultos do sexo masculino, entre 20 e 30 anos, são os mais acometidos por lesões de face. Mandíbula e complexo zigomático são as regiões mais suscetíveis a fraturas. As altas taxas de violência na região e o não uso de equipamentos de proteção por motociclistas têm influência direta nos índices de fraturas de face.
Recursos da Odontologia digital para o treinamento de residentes em Cirurgia Buco-Maxilo-Facial durante a pandemia de COVID-19
Authors: Candido Isabella Romão , Garcia Eduardo dos Santos , Gialain Ivan Onone , Grillo Ricardo , Han Michael D. , Miloro Michael , Borba Alexandre Meireles
Published: March 2024

Introdução: As tecnologias tridimensionais (3D) têm se mostrado uma importante ferramenta auxiliar no planejamento cirúrgico, possibilitando melhor manejo operatório, aumentando a previsibilidade do tratamento e melhorando os resultados. Objetivo: O objetivo desse estudo foi avaliar os resultados do uso de uma rotina de impressão 3D em um ambiente cirúrgico acadêmico. Métodos: Indivíduos agendados para cirurgia buco-maxilo-facial cujos procedimentos se beneficiariam da impressão 3D para percepção diagnóstica e planejamento cirúrgico tiveram sua anatomia maxilofacial impressa em 3D. Além dos dados demográficos, o peso dos modelos 3D foi registrado, para estimar o custo de impressão. O tempo gasto para a fixação do material pré-dobra foi comparado com o tempo intraoperatório necessário para adaptar o hardware pré-dobrado. Resultados: Foram avaliados 10 indivíduos do sexo masculino submetidos à correção de fraturas faciais. O custo médio de cada modelo impresso em 3D foi de aproximadamente US$ 2,00, o tempo médio de pré-dobra foi de 33 minutos e o tempo de adaptação do hardware intraoperatório foi de 6 minutos. Conclusões: Quando comparada com o planejamento 2D, a impressão 3D pré-operatória reduz o tempo de operação, com baixos custos de impressão. Os modelos impressos em 3D são uma importante ferramenta de ensino, permitindo que os residentes manuseiem indiretamente o paciente enquanto estão envolvidos no cuidado ao paciente; esse é um tema relevante em tempos de pandemia da COVID-19.
Expectativas do JBCOMS para o ano de 2024
Authors: Ribeiro Jonathan
Published: March 2024

O ano de 2023 foi marcado por ajustes no perfil dos artigos da nossa revista, onde foi possível instituir um protocolo de revisão otimizada que diminuiu o tempo de resposta aos autores, e aumentamos a quantidade de trabalhos publicados na modalidade de artigos originais. A partir dessas mudanças o JBCOMS passou a atingir os critérios necessários para pleitear as primeiras indexações.
55 anos de história e nova parceria para os membros adimplentes
Authors: Germano Adriano Rocha
Published: March 2024

O Colégio Brasileiro de Cirurgia e Traumatologia Buco-Maxilo-Facial (CBCTBMF), no ano em que celebra os 55 anos de sua fundação e 10 anos de sua Revista Científica, tem o prazer de anunciar mais um benefício. O CBCTBMF, por meio de mais uma parceria com a empresa KLS MARTIN, está oferecendo aos nossos membros adimplentes um desconto exclusivo nos preços de aquisição e manutenção do software IPS Case Designer®. Além do desconto no preço, os associados que optarem pela aquisição dos produtos e manutenção do software IPS Case Designer® também terão direito a um treinamento básico, disponível em português ou inglês, para uma utilização eficaz e otimizada do software.
Tratamento conservador de ameloblastoma plexiforme em paciente adolescente: relato de caso
Authors: Santos Paula Perrotta dos Reis , Correa Carla Vieira Marques , Souza Gines Alves de , Louzada Guilherme Pivatto , Menegat Fabiano
Published: March 2024

Introdução: O ameloblastoma é uma neoplasia óssea benigna, que apresenta um comportamento localmente agressivo, devido à sua característica invasiva e infiltrativa, o que torna o tratamento um desafio, devido às altas taxas de recidiva. Objetivo: O objetivo do presente trabalho foi avaliar a eficácia da descompressão e marsupialização de um ameloblastoma plexiforme, a partir da análise da regressão dimensional volumétrica observada por meio de exame de tomografia computadorizada de feixe cônico (TCFC). Relato de caso: Paciente do sexo feminino, 13 anos de idade, apresentando, no exame de TCFC, lesão radiolúcida unilocular envolvendo o dente #47, com deslocamento do #48 e estendendo-se pelo corpo e ramo mandibular direito, sem sinais de reabsorção radicular. Foi realizada descompressão durante seis meses e, após a obtenção de redução volumétrica apreciável, que permitisse uma segunda intervenção de forma segura e sem causar a fragilização da mandíbula, optou-se pela enucleação completa da lesão, associada à ostectomia periférica e exodontia dos dentes envolvidos (#47 e #48). Atualmente, a paciente se encontra em acompanhamento pós-operatório de 7 anos e 5 meses, sem sinais de recidiva. Conclusão: A opção pelo tratamento com descompressão, seguida da enucleação total do ameloblastoma unicístico plexiforme, se demonstrou efetiva, sem complicações e com a manutenção de funções oclusais satisfatórias.
Design of a Novel Creel Conditioning System for Circular Knitting Machines
Authors: Yıldırımkaraman Filiz , Marmarali Arzu , Oğlakcıoğlu Nida
Published: March 2024

Maintaining a certain humidity level of humidity in yarn packages and removing fibre fly from the environment is very important for production efficiency and product quality in textile mills. Humidity has a significant effect on the quality and efficiency of fabrics, especially those made from hydrophilic fibres. The high temperature and low humidity level in the factory environment results in lower yarn strength and higher yarn breakage. The solution is to provide optimum temperature and humidity levels through a central air conditioning system. However, conditioning the entire factory environment is an expensive approach and does not facilitate satisfactory production efficiency. In this study, a new creel system for circular knitting machines was designed to provide excellent yarn package conditioning. More efficient production and economical conditioning were achieved with this new creel system.
Triple Combination with Direct Acting Antivirals in the Treatment of Hepatitis C Does not Prolong the QT Interval
Authors: Šimka Jakub , Pudil Radek , Fialová Monika , Varhaník Filip , Plíšek Stanislav , Pařízek Petr
Published: March 2024

Aims: Antiviral drugs are considered as potentially cardiotoxic, due to prolongation of QT interval which may affect incidence of severe ventricular arrhythmias. The main aim of this retrospective study was to assess the influence of treatment by three antiviral drugs on QT interval and to find patients who are at an increased risk of developing malignant ventricular arrhythmias. Methods: The study included 23 patients (14 men, 9 women) who were treated with a combination of interferon alpha, ribavirin, and an NS3/4A protease inhibitor. The parameters from the 12 leads electrocardiograms were evaluated before treatment, and then 3 ± 1 and 6 ± 1 months after treatment. Results: Heart rate (HR) 69 ± 12 / min and corrected QT interval (QTc) 412 ± 35 ms were obtained before the treatment and there was not observed a significant prolongation of intervals after 3 months (HR 72 ± 11 / min, QTc 412 ± 33 ms) and after 6 months (HR 64 ± 12 / min, QTc 405 ± 28 ms) respectively. In total QTc interval was prolonged from the baseline in 53% and in 43% of the patients 3 months respectively 6 months after treatment. A QTc prolongation over of 450 ms and new treatment-related repolarization change was noted in 1 (4%) patient. Conclusion: The study demonstrates that a combination therapy of 3 antiviral drugs does not significantly prolong the QTc interval and does not cause severe pathological changes on the ECG. Patients undergoing this treatment are not at risk of developing heart disease as an undesirable side effect.