bluuebunny/crossref_metadata_2025 huggingface dataset:
Morphometric analysis of aerobic Eimeria bovis sporogony using live cell 3D holotomographic microscopy imaging
Authors: Lopez-Osorio Sara , Velasquez Zahady D. , Conejeros Iván , Taubert Anja , Hermosilla Carlos
Published: October 2021

M
onoxenous Eimeria species are widespread enteropathogenic apicomplexan protozoa with a high economic impact on livestock. In cattle, tenacious oocysts shed by E. bovis-infected animals are ubiquitously found and making infection of calves almost inevitable. To become infectious oocysts, exogenous oxygen-dependent E. bovis sporogony must occur leading to the formation of sporulated oocysts containing four sporocysts each harboring two sporozoites. Investigations on sporogony by live cell imaging techniques of ruminant Eimeria species are still absent in literature as commonly used fluorescent dyes do not penetrate resistant oocyst bi-layered wall. Sporogonial oocysts were daily analyzed by a 3D Cell Explorer Nanolive microscope to explore ongoing aerobic-dependent sporogony as close as possible to an in vivo situation. Subsequently, 3D holotomographic images of sporulating E. bovis oocysts were digitally stained based on refractive indices (RI) of oocyst bi-layered wall and sub-compartments of circumplasm using STEVE software (Nanolive), and the cellular morphometric parameters were obtained. Overall, three different E. bovis sporogony phases, each of them divided into two sub-phases, were documented: (i) sporoblast/sporont transformation into sporogonial stages, (ii) cytokinesis followed by nuclear division, and finally (iii) formation of four sporocysts with two fully developed sporozoites. Approximately 60% of sporulating E. bovis oocysts accomplished aerobic sporogony in a synchronized manner. E. bovis sporogony was delayed (i.e., 6 days) when compared to an in vivo situation where 2–3 days are required but under optimal environmental conditions. Live cell 3D holotomography analysis might facilitate the evaluation of either novel disinfectants- or anti-coccidial drug-derived effects on ruminant/avian Eimeria sporogony in vitro as discrimination of sporogony degrees based on compactness, and dry mass was here successfully achieved. Main changes were observed in the oocyst area, perimeter, compactness, extent, and granularity suggesting those parameters as an efficient tool for a fast evaluation of the sporulation degree.
A pathogenic deletion in Forkhead Box L1 (FOXL1) identifies the first otosclerosis (OTSC) gene
Authors: Abdelfatah Nelly , Mostafa Ahmed A. , French Curtis R. , Doucette Lance P. , Penney Cindy , Lucas Matthew B. , Griffin Anne , Booth Valerie , Rowley Christopher , Besaw Jessica E. , Tranebjærg Lisbeth , Rendtorff Nanna Dahl , Hodgkinson Kathy A. , Little Leichelle A. , Agrawal Sumit , Parnes Lorne , Batten Tony , Moore Susan , Hu Pingzhao , Pater Justin A. , Houston Jim , Galutira Dante , Benteau Tammy , MacDonald Courtney , French Danielle , O’Rielly Darren D. , Stanton Susan G. , Young Terry-Lynn
Published: October 2021

Otosclerosis is a bone disorder of the otic capsule and common form of late-onset hearing impairment. Considered a complex disease, little is known about its pathogenesis. Over the past 20 years, ten autosomal dominant loci (OTSC1-10) have been mapped but no genes identified. Herein, we map a new OTSC locus to a 9.96 Mb region within the FOX gene cluster on 16q24.1 and identify a 15 bp coding deletion in Forkhead Box L1 co-segregating with otosclerosis in a Caucasian family. Pre-operative phenotype ranges from moderate to severe hearing loss to profound sensorineural loss requiring a cochlear implant. Mutant FOXL1 is both transcribed and translated and correctly locates to the cell nucleus. However, the deletion of 5 residues in the C-terminus of mutant FOXL1 causes a complete loss of transcriptional activity due to loss of secondary (alpha helix) structure. FOXL1 (rs764026385) was identified in a second unrelated case on a shared background. We conclude that FOXL1 (rs764026385) is pathogenic and causes autosomal dominant otosclerosis and propose a key inhibitory role for wildtype Foxl1 in bone remodelling in the otic capsule. New insights into the molecular pathology of otosclerosis from this study provide molecular targets for non-invasive therapeutic interventions.
A new class of multidimensional Wishart-based hybrid models
Authors: La Bua Gaetano , Marazzina Daniele
Published: October 2021

In this article, we present a new class of pricing models that extend the application of Wishart processes to the so-called stochastic local volatility (or hybrid) pricing paradigm. This approach combines the advantages of local and stochastic volatility models. Despite the growing interest on the topic, however, it seems that no particular attention has been paid to the use of multidimensional specifications for the stochastic volatility component. Our work tries to fill the gap: we introduce two hybrid models in which the stochastic volatility dynamics is described by means of a Wishart process. The proposed parametrizations not only preserve the desirable features of existing Wishart-based models but significantly enhance the ability of reproducing market prices of vanilla options.
Visualising user–website interaction: description and evaluation of a teaching method
Authors: Więckowska Marta , Rudnicka Patrycja
Published: October 2021

This paper presents a teaching method applied in a usability research course that is part of a bachelor degree programme at the Academy of Fine Arts in Katowice. The method employs visualisation techniques of the user–website interaction, a design practice popular in other fields, but less often used in usability studies. The theoretical background of the data visualisation method, as well as examples of its use in research, are presented and discussed in this paper. In addition to presenting the method, the paper evaluates and analyses how students have responded to it. Using the technology acceptance model, we identified the perceived usability of the method as the main factor influencing students’ behavioural intention to use it in the future.
Correction to: Conditional Action and Quantum Versions of Maxwell’s Demon
Authors: Schmidt Heinz-Jürgen
Published: October 2021

The article “Conditional Action and Quantum Versions of Maxwell’s Demon”, written by Heinz‑Jurgen Schmidt, was originally published electronically on the publisher’s internet portal on 30 September 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 17 September 2021 to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0. The original article has been corrected.
Zooarchaeology of Mission Santa Clara de Asìs: Bone Fragmentation, Stew Production, and Commensality
Authors: Noe Sarah J.
Published: October 2021

Through the analysis of faunal remains from refuse features associated with the Native Californian living quarters at Mission Santa Clara de Asìs, the article examines Indigenous diet within this colonial mission settlement. In Alta California, Native Californians from differing sociolinguistic groups were relocated to Spanish missions, creating an ever shifting pluralistic society. Within these mission settlements, Native Californians were tasked with maintaining the vast agricultural fields for which they received ingredients for two Spanish-style meals, atole and pozole. This study examines the diet of Native Californian families living within Mission Santa Clara, specifically focusing on the breakage patterns of cattle bones and the communal preparation, cooking, and consumption of these daily meals. These results illustrate change and continuity of foodway practices, expanding our understanding of mission political economies and Native Californian persistence within this colonial system.
Weak KAM Approach to First-Order Mean Field Games with State Constraints
Authors: Cannarsa Piermarco , Cheng Wei , Mendico Cristian , Wang Kaizhi
Published: October 2021

We study the asymptotic behavior of solutions to the constrained MFG system as the time horizon T goes to infinity. For this purpose, we analyze first Hamilton–Jacobi equations with state constraints from the viewpoint of weak KAM theory, constructing a Mather measure for the associated variational problem. Using these results, we show that a solution to the constrained ergodic mean field games system exists and the ergodic constant is unique. Finally, we prove that any solution of the first-order constrained MFG problem on [0, T] converges to the solution of the ergodic system as T goes to infinity.
Exposure-response modeling improves selection of radiation and radiosensitizer combinations
Authors: Cardilin Tim , Almquist Joachim , Jirstrand Mats , Zimmermann Astrid , Lignet Floriane , El Bawab Samer , Gabrielsson Johan
Published: October 2021

A central question in drug discovery is how to select drug candidates from a large number of available compounds. This analysis presents a model-based approach for comparing and ranking combinations of radiation and radiosensitizers. The approach is quantitative and based on the previously-derived Tumor Static Exposure (TSE) concept. Combinations of radiation and radiosensitizers are evaluated based on their ability to induce tumor regression relative to toxicity and other potential costs. The approach is presented in the form of a case study where the objective is to find the most promising candidate out of three radiosensitizing agents. Data from a xenograft study is described using a nonlinear mixed-effects modeling approach and a previously-published tumor model for radiation and radiosensitizing agents. First, the most promising candidate is chosen under the assumption that all compounds are equally toxic. The impact of toxicity in compound selection is then illustrated by assuming that one compound is more toxic than the others, leading to a different choice of candidate.
Loss on ignition vs. thermogravimetric analysis: a comparative study to determine organic matter and carbonate content in sediments
Authors: Bensharada Mohammed , Telford Richard , Stern Ben , Gaffney Vince
Published: October 2021

Mass loss at specified temperatures has been used widely to determine amounts of organic matter and carbonate in sediment samples. The loss on ignition (LOI) method is cheap and simple, but is time-consuming and provides information only for specific, pre-determined temperatures. It also requires relatively large sample sizes and is destructive. Thermogravimetric analysis (TGA) is an alternative method for determination of organic and carbonate content in sediment samples, and provides accurate and precise data in a time-efficient manner. We compared results from these two thermal analysis techniques, which were applied to sediment samples from a submerged landscape (Doggerland). An organic-rich peat sample and a silty fine-sand sample were used. An unpaired t-test was used to test agreement and repeatability of the two analytical techniques. One advantage of being able to monitor mass loss throughout the analytical operation is that free and bound moisture losses can be distinguished. TGA is less time-consuming, involves automated sample handling (minimising operator error), and can yield reliable data from sample masses (typically 30–50 mg), which are much smaller than those needed for LOI (typically 3–5 g). The unpaired t-test, along with precision and repeatability analyses led us to conclude that TGA can be used instead of LOI to provide reliable measures of organic matter and carbonate content in sediments, and has several advantages over LOI.
Multinomial Sampling of Latent Variables for Hierarchical Change-Point Detection
Authors: Romero-Medrano Lorena , Moreno-Muñoz Pablo , Artés-Rodríguez Antonio
Published: October 2021

Bayesian change-point detection, with latent variable models, allows to perform segmentation of high-dimensional time-series with heterogeneous statistical nature. We assume that change-points lie on a lower-dimensional manifold where we aim to infer a discrete representation via subsets of latent variables. For this particular model, full inference is computationally unfeasible and pseudo-observations based on point-estimates of latent variables are used instead. However, if their estimation is not certain enough, change-point detection gets affected. To circumvent this problem, we propose a multinomial sampling methodology that improves the detection rate and reduces the delay while keeping complexity stable and inference analytically tractable. Our experiments show results that outperform the baseline method and we also provide an example oriented to a human behavioral study.
An applicability assessment and sensitivity analysis of land use impact models: application of the LANCA model in site-specific conditions
Authors: Terranova D. , Balugani E. , Righi S. , Marazza D.
Published: October 2021

Purpose

In this work, we study a land use impact model with the aim of obtaining spatially differentiated as opposed to default average characterisation factors. In particular, we study the application of LANCA®, a multi-indicator model with available country average characterisation factors expressing the alteration of the soil quality level of the current land use of one kind with respect to a reference situation.

Method

To this purpose, we use the LANCA® method documentation at a higher spatial resolution and apply all the required elemental steps. From a user perspective, we score the transparency of the method down to the basic methodological references and single out the source of errors that the user may incur when: (i) collecting the input data, (ii) selecting the appropriate soil/land classes and (iii) applying the individual calculation steps. For a greater insight, we couple the source of errors with a sensitivity analysis.

Results

In the comparison between a site-specific test area and the related country default values, we obtained relevant discrepancies regarding the erosion resistance and the physicochemical filtration of the soil. For example, we find that the erosion resistance potential is −1.06 * 10−3 kg m2 a−1 locally while the country default value is 13.1. We explain differences through the sensitivity analysis and having analysed in depth the underpinned soil erosion equation and the critical steps for its calibration. Together with systematic errors, we find that the method generally implies 9 scarcely guided steps out of 42, and one-third of the basic methodologies are not fully explained or accessible. These factors make the results related to Biotic Production, Mechanical Filtration, Physicochemical Filtration and Groundwater Regeneration user dependent and — in this sense — difficult to replicate.

Conclusions

From the analysis, we distil 7 main directions for improvement addressed to LANCA® and soil models especially in sight of a broader application of a regionalised life cycle impact assessment.
A framework linking farming resilience with productivity: empirical validation from Poland in times of crises
Authors: Zawalińska Katarzyna , Wąs Adam , Kobus Paweł , Bańkowska Katarzyna
Published: October 2021

Farming sectors’ resilience has been built over decades with the aid of policies and institutions. However, its actual standing can be assessed in times of crises when farms have to overcome particular challenges. We use a large-scale farming sectors dataset FADN spanning 2006–2015 in which two major economic crises occurred—the global economic crisis of 2008 and the Russian embargo of 2014—to exemplify our approach to resilience’s assessment based on the Polish farming sectors. We introduce a distinction between “potential resilience” versus “revealed resilience” where the former is assessed based on resilience capacities (robustness, adaptability and transformability), while the latter is assessed based on the observed decomposition of total factor productivity (TFP) changes in response to the adverse economic shocks. Hence, the proposed framework directly links productivity with the two types of resilience. We applied the Färe-Primont method of TFP decomposition, into technological change and various types of efficiency changes and a detailed farm survey to distinguish between the drivers of technological changes in each farming sector such as specific innovations and ecosystem services. Our findings show that farms differ in their revealed resilience both among the sectors and between two different shock events. Only field crop farms and granivores farms (pig and poultry) maintained their resilience to both crises, staying robust and/or adaptable. The former had the most productive technology and were leaders in applying innovations while the latter were second best in innovations and fairly good in their application of ecosystem-based services into their technology. Other farm types failed to be resilient to the first crisis but proved robust during the second. The outcomes of the study have implications for sustainability oriented policies.
Polyphenols leaching and seed dormancy in carob (Ceratonia siliqua L.) in relation to hot water treatment
Authors: Cavallaro Valeria , Maucieri Carmelo , Patanè Cristina , Fascella Giancarlo , Pellegrino Alessandra , Barbera Antonio C.
Published: October 2021

Carob (Ceratonia siliquaL.) is a relevant element of the Mediterranean spontaneous vegetation. Moreover, it is useful in reforestation, and it is currently re-valued for sustainable agriculture in dryland areas. However, the difficulties tied to carob propagation (mainly seed dormancy) hamper its large-scale cultivation. In this paper, the effects of four seed treatments (no treatment [control], soaking at 70 °C and 90 °C in water, or in 96% sulphuric acid) on five carob genotypes germination were studied. As compared to the very low germination of untreated seeds (0–13% germination), sulphuric acid (93–100% germination) and 90 °C water soaking (from 72 to > 90% germination in four out the five genotypes) were effective in promoting germination. Soaking at 90 °C resulted in the leaching of a higher amount of total polyphenols from the genotypes seed coat as compared to soaking at 70 °C. A significant correlation (0.75**) was ascertained between polyphenol leaching of the different genotypes and germination. These results suggest that dormancy in this species is not primarily associated with seed coat hardness, as it is generally thought, but also with the release of polyphenols. Polyphenols determination of the dormant and the few non-dormant seeds of the different genotypes also seem to confirm this hypothesis since these last showed an almost halved total polyphenols content (on average 17.0) as compared to dormant ones (34.8 mg g−1of seed FW). Further studies may determine the polyphenols involved, but also assess new, easier to carry out, seed treatments. The important role of the galactomannans on seed germination of carob is also discussed. Finally, similar studies may enhance the knowledge of dormancy processes in otherFabaceaespecies whose germination is positively affected by hot water treatments.
Revisiting Gaussian copulas to handle endogenous regressors
Authors: Becker Jan-Michael , Proksch Dorian , Ringle Christian M.
Published: October 2021

Marketing researchers are increasingly taking advantage of the instrumental variable (IV)-free Gaussian copula approach. They use this method to identify and correct endogeneity when estimating regression models with non-experimental data. The Gaussian copula approach’s original presentation and performance demonstration via a series of simulation studies focused primarily on regression models without intercept. However, marketing and other disciplines’ researchers mainly use regression models with intercept. This research expands our knowledge of the Gaussian copula approach to regression models with intercept and to multilevel models. The results of our simulation studies reveal a fundamental bias and concerns about statistical power at smaller sample sizes and when the approach’s primary assumptions are not fully met. This key finding opposes the method’s potential advantages and raises concerns about its appropriate use in prior studies. As a remedy, we derive boundary conditions and guidelines that contribute to the Gaussian copula approach’s proper use. Thereby, this research contributes to ensuring the validity of results and conclusions of empirical research applying the Gaussian copula approach.
Stochastic monotonicity of dependent variables given their sum
Authors: Pellerey Franco , Navarro Jorge
Published: October 2021

Given a finite set of independent random variables, assume one can observe their sum, and denote with s its value. Efron in 1965, and Lehmann in 1966, described conditions on the involved variables such that each of them stochastically increases in the value s, i.e., such that the expected value of any non-decreasing function of the variable increases as s increases. In this paper, we investigate conditions such that this stochastic monotonicity property is satisfied when the assumption of independence is removed. Comparisons in the stronger likelihood ratio order are considered as well.
Acceptance of matchmaking tools in coworking spaces: an extended perspective
Authors: Kopplin Cristopher Siegfried , Gantert Till Marius , Maier Julia Verena
Published: October 2021

An extended technology acceptance model for matchmaking tools in coworking spaces is presented and tested among 92 German coworkers. Advancing previous research, hedonic and community-related aspects are integrated into a framework based on the extended unified theory of acceptance and use of technology (UTAUT2). Coworkers emphasize a matchmaking tool’s productivity aspects, which are positively moderated by their sense of community. Hedonic motivation (HM) and personal innovativeness contribute to usage intention, while effort expectancy is not a driver. The influence of HM is negatively moderated by sense of community, suggesting that a favorable social atmosphere that is explorable in person acts as a partial substitute for the enjoyment of tool usage. Surprisingly, satisfaction with face-to-face activities does not affect their perception of a matchmaking tool.
ASCO 2021: Highlights in central nervous system tumors
Authors: Mair Maximilian J. , Berghoff Anna S.
Published: October 2021

More than 140 abstracts were presented in the Central Nervous System Tumors track during the 2021 American Society of Clinical Oncology (ASCO) virtual meeting. Here, we review our personal highlights of the presented data. In rare entities such as papillary craniopharyngioma and neurotrophic tyrocine receptor kinase (NTRK)-fusion-positive tumors, promising data on targeted therapies were reported. In addition, early data on olaparib in high-grade glioma and combinational immunotherapy approaches will be briefly reviewed. Furthermore, the eagerly awaited results of the EORTC-1709 phase III trial on the pan-proteasome inhibitor marizomib in newly diagnosed glioblastoma were shown at the meeting. Although no practice-changing trials were presented for glioma patients, new treatments are on the horizon and results from modern platform trials are awaited in the near future.
The arbitration of nature: state, water, and civil engineering in Northern Ireland directly after partition
Authors: Reinsborough Michael
Published: October 2021

Begun in the summer of 1923, the Silent Valley Reservoir was the first large scale civil engineering project after the division between the North and the South of Ireland. It was the continuation of a previous project. In the late Nineteenth Century a portion of the Kilkeel and Annalong Rivers in the Mourne Mountains had been diverted 35 miles to provide water for the growing industrial city of Belfast in the North of Ireland. A reservoir in the mountains was also planned at a later date but this was delayed by the Great War and then by Irish political instability and the high cost of construction in immediate post war period. Before being completed the project had to overcome several obstacles. Firstly, the Mourne Mountains were claimed by the South of Ireland and thus subject to the Boundary Commission of the Anglo-Irish peace treaty. The Water Commissioners had brought important British political leaders to tour the Silent Valley construction site in an attempt to demonstrate how implausible a situation (in their opinion) that the South should control the major water supply to the capital city of the North. Secondly, shortly after the Boundary Commission was shelved, the combination of fluid subsoil and the failure to locate bedrock at expected depth brought construction to a halt while an engineering, political, and legal solution was sought for the expensive and now publicly controversial project. This article traces the contingent relationship between state (sovereignty) and technology (water reservoir) using a socio legal and socio material description of the crucial arbitration process enabling further time and resources for resolution of the difficulty. Ultimately an air-shaft device for excavating under increased atmospheric pressure had to be designed taking in mind both technical and political difficulties. Today the 3000-million-gallon reservoir, first imagined in the late Nineteenth Century, continues to be a major water source for the city of Belfast.
Formal models of the scientific community and the value-ladenness of science
Authors: Politi Vincenzo
Published: October 2021

In the past few years, social epistemologists have developed several formal models of the social organisation of science. While their robustness and representational adequacy has been analysed at length, the function of these models has begun to be discussed in more general terms only recently. In this article, I will interpret many of the current formal models of the scientific community as representing the latest development of what I will call the ‘Kuhnian project’. These models share with Kuhn a number of questions about the relation between individuals and communities. At the same time, they also inherit some of Kuhn’s problematic characterisations of the scientific community. In particular, current models of the social organisation of science represent the scientific community as essentially value-free. This may put into question both their representational adequacy and their normative ambitions. In the end, it will be shown that the discussion on the formal models of the scientific community may contribute in fruitful ways to the ongoing debates on value judgements in science.
Organizational issues in embracing Agile methods: an empirical assessment
Authors: Mishra Alok , Abdalhamid Samia , Mishra Deepti , Ostrovska Sofiya
Published: October 2021

This study provides empirical evidence to the body of knowledge in Agile methods adoption in small, medium and large organizations in international context. This research explores the factors involved in the adoption of Agile methods in software development organizations. A survey was conducted among Agile professionals to gather survey data from 52 software organizations in seven countries across the world. Statistical techniques are applied towards empirical assessment. Organizational culture, team structure and management support are found to be crucial success factors whereas lack of management support, a large organization size and traditional organizational culture are found to be detrimental for the adoption of Agile approach in an organization. The selection of an appropriate Agile method depends on the project size and, for each size, there are specific methods preferred by different enterprises. Providing better control over the work is viewed as the primary advantage of the Agile methods within large and small organizations, while for the medium-size organizations, the priority is switched to coping with changing user requirements. Majority of the respondents did not consider embracing agile methods as a reason for project failure which indicates that Agile methods are, indeed, beneficial.
Multiple solutions for superlinear double phase Neumann problems
Authors: Papageorgiou Nikolaos S. , Rădulescu Vicenţiu D. , Zhang Youpei
Published: October 2021

We study a double phase Neumann problem with a superlinear reaction which need not satisfy the Ambrosetti-Rabinowitz condition. Using the Nehari manifold method, we show that the problem has at least three nontrivial bounded ground state solutions, all with sign information (positive, negative and nodal).
Assessing Capacity and Implementation Status of the Disaster Risk Management Strategy for Health and Community Disaster Resilience in Malawi
Authors: Dewa Ozius , Makoka Donald , Ayo-Yusuf Olalekan A.
Published: October 2021

Floods are among the most frequently occurring natural hazards in Malawi, often with public health implications. This mixed methods study assessed the capacity for and implementation status of the disaster risk management (DRM) strategy for the health sector in Malawi, using flooding in the Nsanje District as a case. Data were collected using desk review and a workshop methodology involving key officials from government ministries, national and international development partners, and the academia. The results show that Malawi had recently strengthened its DRM institutional frameworks, with a pronounced policy shift from reactive to proactive management of disasters. Health sector personnel and structures were key contributors in the design and implementation of DRM activities at all levels. Development partners played a significant role in strengthening DRM coordination and implementation capacity. Lack of funding and the limited availability, and often fragmented nature, of vulnerability and risk assessment data were identified as key challenges. Limited human resource capacity and inadequate planning processes at district level impeded full implementation of DRM policies. These findings call for community-level interventions for improved coordination, planning, and human resource capacity to strengthen community disaster resilience and improve public health. The approach used in this study can serve as a model framework for other districts in Malawi, as well as in other low- and middle-income countries in the context of Sendai Framework implementation.
Early life factors in relation to albuminuria and estimated glomerular filtration rate based on cystatin C and creatinine in adults from a Swedish population-based cohort study
Authors: Laucyte-Cibulskiene Agne , Sharma Shantanu , Christensson Anders , Nilsson Peter M.
Published: October 2021

Background

Early life factors influence the number of nephrons a person starts life with and a consequence of that is believed to be premature kidney ageing. Thus, we aimed to identify early life factors associated with cystatin C and creatinine-based estimated glomerular filtration (eGFR) rate equations and urine -albumin-to-creatinine ratio after a follow-up of 46–67 years.

Methods

The study included 593 Swedish subjects without diabetes mellitus from the Malmo Diet Cancer Cohort. Perinatal data records including birth weight, gestational age, placenta weight and maternal related risk factors were analysed. eGFR was determined by Chronic Kidney Disease Epidemiology (CKD-EPI), the Lund-Malmö revised and Caucasian, Asian, Paediatric, and Adult (CAPA) equations. Postnatal growth phenotypes were defined as low (≤ 0) or high (> 0) birth weight z-score, or low (≤ median) or high (> median) body mass index at 20 years of age.

Results

In women, lower birth weight was associated with lower eGFR (CAPA; CKD-EPI cystatin C). Birth weight z-score predicted adult albuminuria specifically in men (OR 0.75, 95% CI [0.58; 0.96]). Women with high birth weight z-score and low BMI at 20 years had lower eGFR (CAPA; CKD-EPI cystatin C; p = 0.04). Men with high birth weight z-score and high BMI at 20 years had lower risk for albuminuria (OR 0.35, 95% CI [0.12; 0.93]).

Conclusions

Lower birth weight, prematurity and postnatal growth curve have a potential sex- specific effect of early exposure to an adverse environment on lower cystatin C-based eGFR and albuminuria later in life. Cystatin C compared to creatinine -eGFR equations shows a higher ability to detect these findings.

Graphic abstract
Embitterment – Conception of a Potential Moderator to Dysfunctional and Aggressive Behaviour in Children and Adolescents
Authors: Balder Tim , Linden Michael
Published: October 2021

Embitterment is an emotion which is known to everybody in reaction to injustice, humiliation, and breach of trust. Children and adolescents have an understanding of justice/injustice and fairness, violations of injustice, humiliation, and breach of trust are also stressors at a young age. In this conceptual paper it is argued that embitterment is also seen in children and adolescents, and that parents, educators and therapists should recognize this emotion. This could possibly help to early identify children at risk for severe dysfunctional and aggressive behaviours, when preventive interventions are still possible. The article concludes with concepts on how to diagnose and treat children with embitterment.
Facing the complexity of the economy: an opportunity for the new alliance between economics and engineering
Authors: Cincotti Silvano
Published: October 2021

InForging a new alliance between economics and engineering, Sergio Mariotti explores the relationship between economics and engineering. The interactions between economics and engineering is a question rather than trivial and Mariotti faces the problem, firstly, from an historical perspective and, secondly, by identifying the paradigms for the economics–engineering nexus. Three paradigms are proposed, i.e., economics for engineering, economics and engineering, economics as engineering. They offer the opportunity to open new vistas on the future of the relationships between economics and engineering, in particular for facing the complexity of the economy.
Composition Optimization and Microstructure Design in MOFs-Derived Magnetic Carbon-Based Microwave Absorbers: A Review
Authors: Zhao Honghong , Wang Fengyuan , Cui Liru , Xu Xianzhu , Han Xijiang , Du Yunchen
Published: October 2021

Magnetic carbon-based composites are the most attractive candidates for electromagnetic (EM) absorption because they can terminate the propagation of surplus EM waves in space by interacting with both electric and magnetic branches. Metal-organic frameworks (MOFs) have demonstrated their great potential as sacrificing precursors of magnetic metals/carbon composites, because they provide a good platform to achieve high dispersion of magnetic nanoparticles in carbon matrix. Nevertheless, the chemical composition and microstructure of these composites are always highly dependent on their precursors and cannot promise an optimal EM state favorable for EM absorption, which more or less discount the superiority of MOFs-derived strategy. It is hence of great importance to develop some accompanied methods that can regulate EM properties of MOFs-derived magnetic carbon-based composites effectively. This review comprehensively introduces recent advancements on EM absorption enhancement in MOFs-derived magnetic carbon-based composites and some available strategies therein. In addition, some challenges and prospects are also proposed to indicate the pending issues on performance breakthrough and mechanism exploration in the related field.
Reconceptualizing natural capital and sustainable use of natural capital through Aldo Leopold's land ethic
Authors: Fernando Felix N.
Published: October 2021

This article reconceptualizes natural capital. It categorizes natural capital into renewable natural capital and structural natural capital, and argues for exclusion of nonrenewable natural capital (such as coal and oil) from consideration as a natural capital. It presents 10 guiding principles for sustainable use of natural capital. Both tasks of reconceptualizing natural capital and identifying guiding principles for sustainable use of natural capital are inspired by Aldo Leopold’s land ethic.
The Privacy Fix
Authors: Sloan Robert H. , Warner Richard
Published: October 2021

Online surveillance of our behavior by private companies is on the increase, particularly through the Internet of Things and the increasing use of algorithmic decision-making. This troubling trend undermines privacy and increasingly threatens our ability to control how information about us is shared and used. Written by a computer scientist and a legal scholar, The Privacy Fix proposes a set of evidence-based, practical solutions that will help solve this problem. Requiring no technical or legal expertise, the book explains complicated concepts in clear, straightforward language. Bridging the gap between computer scientists, economists, lawyers, and public policy makers, this book provides theoretically and practically sound public policy guidance about how to preserve privacy in the onslaught of surveillance. It emphasizes the need to make tradeoffs among the complex concerns that arise, and it outlines a practical norm-creation process to do so.
Concept and Method in Cross-Cultural and Cultural Psychology
Authors: Poortinga Ype H.
Published: October 2021

An overview is given of cross-cultural psychology and cultural psychology, focusing on theory and methodology. In Section 1 historical developments in research are traced; it is found that initially extensive psychological differences tend to shrink when more carefully designed studies are conducted. Section 2 addresses the conceptualization of “culture” and of “a culture”. For psychological research the notion “culture” is considered too vague; more focal explanatory concepts are required. Section 3 describes methodological issues, taking the notion of the empirical cycle as a lead for both qualitative and quantitative research. Pitfalls in research design and data analysis of behavior-comparative studies, and the need for replication are discussed. Section 4 suggests to move beyond research on causal relationships and to incorporate additional questions, addressing the function and the development of behavior patterns in ontogenetic, phylogenetic and historical time. Section 5 emphasizes the need for applied research serving the global village.
Why Challenging Discrimination at Borders is Challenging (and Often Futile)
Authors: Cinnéide Colm Ó
Published: October 2021

International human rights law recognizes a general right to non-discrimination. This right has proved to have plenty of legal “bite.” It is regularly invoked at both international and national levels to challenge state action which discriminates against vulnerable groups on “suspect grounds,” such as race, gender, and disability. Such legal challenges periodically succeed in generating significant law reform and sometimes even social change. However, this (relative) success has not been replicated when it comes to migration control. Non-discrimination challenges to state immigration restrictions have rarely been successful, even though human rights experts, NGOs, and other critics repeatedly express concern about the discriminatory impact of such restrictions. Furthermore, the state of human rights law remains radically underdeveloped in this area: the normative content of international non-discrimination norms, as they apply to migration control, is still lacking substance. This essay seeks to analyze why the cutting edge of the right to non-discrimination becomes blunted at the border, and generally lacks impact when invoked to challenge state migration controls.
Manipulation of single sub-femtolitre droplets via partial coalescence in a direct-current electric field
Authors: Shojaeian Mostafa , Hardt Steffen
Published: October 2021

It is demonstrated how aqueous droplets with volumes down to the sub-femtolitre range can be manipulated, including the withdrawal of minute samples from the droplets. The underlying principle is that of partial coalescence with a liquid reservoir in an applied electric field. Upon partial coalescence, a droplet merges with a reservoir and reappears with a smaller diameter. The droplets studied here perform a reciprocating motion between two reservoirs during which their volume gets reduced. Manipulation of droplets with diameters down to 400 nm is reported. A similarity relation is derived expressing the ratio of droplet diameters before and after partial coalescence as a function of the ratio between electric and interfacial-tension forces. The presented scheme allows the withdrawal of minute samples from small droplets and could prove helpful in various applications where droplets are used as tiny reaction spaces or when the goal is to tailor the size of individual droplets.
Nonvanishing for cubic L-functions
Authors: David Chantal , Florea Alexandra , Lalin Matilde
Published: October 2021

We prove that there is a positive proportion of L-functions associated to cubic characters over

$\mathbb F_q[T]$

that do not vanish at the critical point

$s=1/2$

. This is achieved by computing the first mollified moment using techniques previously developed by the authors in their work on the first moment of cubic L-functions, and by obtaining a sharp upper bound for the second mollified moment, building on work of Lester and Radziwiłł, which in turn develops further ideas from the work of Soundararajan, Harper and Radziwiłł. We work in the non-Kummer setting when

$q\equiv 2 \,(\mathrm {mod}\,3)$

, but our results could be translated into the Kummer setting when

$q\equiv 1\,(\mathrm {mod}\,3)$

as well as into the number-field case (assuming the generalised Riemann hypothesis). Our positive proportion of nonvanishing is explicit, but extremely small, due to the fact that the implied constant in the upper bound for the mollified second moment is very large.
The Inachoididae spider crabs (Crustacea, Brachyura) from the Neogene of the tropical Americas
Authors: Lima Daniel , Aguilera Orangel , Tavares Marcos
Published: October 2021

The spider crabsWillinachoides santanain. gen. n. sp. from the early-middle Miocene of north Brazil andParadasygyius rodriguezin. sp. from the late Miocene of Venezuela are described and illustrated. Additionally,Eoinachoides senniVan Straelen, 1933, from the late Oligocene–early Miocene of Venezuela, is redescribed based on photographs of the holotype, and the diagnosis ofEoinachoides latispinosusCarriol, Muizon, and Secretan, 1987, from the late Miocene of Peru, is emended also on the basis of photographs of the holotype. The past distribution points to a Tethyan background for the current amphi-American Inachoididae, with the oldest fossil species known from the early Eocene Tethyan regions (Pakistan and Italy), and from the late Eocene–late Pliocene of the Americas. The high number of monotypic genera in Inachoididae could be the result of rapid dispersion followed by diversification during the Neogene of the tropical America, facilitated by global and regional events (e.g., eustatic sea level changes, the Mi-1 Oligocene-Miocene boundary global cooling, the global warming period of the Middle Miocene Climate maximum, closure of the Panama Isthmus, and marine incursions into the Amazon Basin). The shoaling and final closure of the Central American Seaway are thought to have critically affected the evolution of the inachoidids and shaped their current distribution patterns.

UUID:http://zoobank.org/6275fdc4-4bfa-4873-9320-3143d4915172.
Terrestrial Realism and the Gravity of World Literature: Joe Sacco’s Seismic Lines
Authors: Davies Dominic
Published: October 2021

Through a close reading of Joe Sacco’s Paying the Land (2020), a graphic novel about the struggle of the Dene people in Canada’s Northwestern territories, this article shows how Sacco effects a “peripheral realism” that draws the systemic continuities of different phases of colonial modernity into view. The article then describes Sacco’s “terrestrial realism,” which combines his peripheral realism with the dialectical participation of the reader as well. Finally, in a concluding theoretical discussion, I consider how the practice of drawing allows us to think through a response to modernity’s combined and uneven development that is both materialist and decolonial at the same time. Although the former typically insists on singularity and totality, and the latter promotes a contradictory plurality, the peripheral and terrestrial realisms of Paying the Land suggest a way for theorists of world literature to find a point of methodological solidarity that is both in and against capitalist modernity’s gravitational force.
Reading Postcolonial Animals with the Animist Code: A Critique of “New” Materialist Animal Studies
Authors: Price Jason D.
Published: October 2021

This article looks at the challenges that animist materialism offers to reading strategies in new materialist animal studies scholarship. Where Rosi Braidotti’s vitalist materialism calls for a neoliteral, anti-metaphorical mode of relating to animals, Harry Garuba identifies metaphor as a primary feature of animist materialist practice in African material culture. After critiquing Rosi Braidotti’s dismissal of the “old” metaphorical ways of relating to animals, the article offers a reading of animals and the animist code in two southern African novels, Alex La Guma’s Time of the Butcherbird (1979) and Mia Couto’s The Last Flight of the Flamingo (2000), to consider the potential of animist codings of animals for resisting colonial necropolitics. Animist materialism offers the potential to raise animals and humans into ethical status by affirming the very knowledges and worldviews that Cartesian, colonial humanism wrote off as nonsense and as a marker of inhumanity.