bluuebunny/crossref_metadata_2025 huggingface dataset:
Delivery workers’ visibility struggles: Weapons of the gig, (extra)ordinary social media, and strikes
Authors: Bulut Ergin , Yeşilyurt Adem
Published: July 2023

How do we interpret the extraordinary visibility and ordinariness of social media as delivery workers resist their precarious working lives? Drawing on fieldwork, interviews, photo elicitation, and digital data collection in Turkey with a focus on delivery workers’ strikes in early 2022, we argue that understanding the delivery workers’ movement requires not only considering spectacular strikes and social media protests but also workers’ everyday forms of resistance and their ordinary uses of social media as part of what we call weapons of the gig. Although not as visible as spectacular street action and social media campaigns, these weapons (motorcycle drivers’ solidarity, algorithmic resistance, and social media use for information sharing, as well as production of humor and resentment) enable the subtle formation of a movement. Our contribution lies in reframing social media use as both an ordinary and extraordinary weapon of delivery workers and approaching workers’ solidarity as a question of continuum. Enabling us to look beyond the antagonisms in the labor process and locate affective tensions in the everyday, this approach allows for seeing workers not only as economic but also as political and affective subjects demanding freedom and searching for meaningful connection in their lives.
Use of a Rapid Rhino in haemorrhage control for penetrating neck injury presenting in traumatic cardiac arrest
Authors: Davies F , O’Meara M , Hudson C
Published: July 2023

Background

Penetrating neck injuries present as serious, life-threatening events which require advanced expeditious management if the patient is to survive without significant morbidity and mortality. In-hospital paradigms for high-volume centres include the use of Foley catheter balloon tamponade to temporarily or definitively control haemorrhage from carotid sheath structures, although these techniques are less commonly deployed in the field.

Case report

We highlight the case of a 25-year-old male who presented to the ambulance service with three self-inflicted neck wounds – one to each of the zones of the neck. The zone 2 wound had transected the internal jugular vein and also the ipsilateral vertebral artery, causing severe haemorrhage leading to hypovolaemic cardiac arrest in a remote farmhouse location. He was treated with a modified tamponade technique, employing the use of a Rapid Rhino 900™ epistaxis catheter, secured with sutures into the zone 2 wound prior to inflation. This resulted in complete haemostasis, which allowed the patient to be volume resuscitated, anaesthetised and flown by air ambulance to the regional trauma centre. His injuries were treated and his recovery was interrupted only by a transient Horner's syndrome.

Discussion

This report showcases the first time this modification of a well-known in-hospital technique was deployed, which proved life-saving in this case and could be of use to others. We discuss the importance of catheter tamponade techniques as opposed to direct packing, in particular for those who need to be transported either within, between or to the hospital. This is in contradistinction to other authors advocating direct packing as the mainstay of treatment.
Relational contract theory, the relevance of actual performance in contractual interpretation and its application to employment contracts in the United Kingdom and Australia
Authors: Gray Anthony Davidson
Published: July 2023

This article articulates a theory of relational contract, as an alternative to traditional freedom of contract philosophy. The law has moved away from freedom of contract to some extent, and it can be criticised on the basis of its unrealistic assumptions and detachment from the typical reality of parties’ contracting. Relational contract theory is a possible suitable alternative theoretical framework. It may be useful in relation to contract interpretation. Specifically, it can be utilised to support a broader approach to contract interpretation, with the court focussing on the entirety of the parties’ relations, including the written terms and also subsequent performance. It enjoys some support in the United Kingdom and in other common law jurisdictions. It can support the view taken by two justices of the High Court of Australia in a recent contract interpretation decision involving employment contracts. The article favours the approach taken by these justices, rather than that of the majority, whose judgment reflects classic contract law sentiments at odds with the general direction of contract law in comparative jurisdictions.
The Sins of the Parents Are to Be Laid Upon the Children: Biased Humans, Biased Data, Biased Models
Authors: Osborne Merrick R. , Omrani Ali , Dehghani Morteza
Published: July 2023

Technological innovations have become a key driver of societal advancements. Nowhere is this more evident than in the field of machine learning (ML), which has developed algorithmic models that shape our decisions, behaviors, and outcomes. These tools have widespread use, in part, because they can synthesize massive amounts of data to make seemingly objective recommendations. Yet, in the past few years, the ML community has been drawing attention to the need for caution when interpreting and using these models. This is because these models are created by humans, from data generated by humans, whose psychology allows for various biases that impact how the models are developed, trained, tested, and interpreted. As psychologists, we thus face a fork in the road: Down the first path, we can continue to use these models without examining and addressing these critical flaws and rely on computer scientists to try to mitigate them. Down the second path, we can turn our expertise in bias toward this growing field, collaborating with computer scientists to reduce the models’ deleterious outcomes. This article serves to light the way down the second path by identifying how extant psychological research can help examine and curtail bias in ML models.
How Do Demand, Supply, and Institutional Factors Influence SME Financial Inclusion: A Developing Country Perspective
Authors: Thathsarani Shanika , Jianguo Wei , Alariqi Mona
Published: July 2023

Greater access to finance by SMEs in developing countries is one of the most import powerful strategies to reduce poverty and unemployment issues and promote economic growth. The main objective of this study is to construct financial inclusion index for SMEs and identify the determinants of SMEs’ financial inclusion. The data are collected from the primary survey conducted in Sabaragamuwa province using the Stratified Random sampling method to achieve the abovementioned aims. A sample of 139 SMEs is used to analyze the data from a well-structured questionnaire. Principal Component Analysis (PCA) and Multiple Regression Analysis are applied to construct an index and identifying factors. The study’s findings reveal that the financial inclusion index for SMEs is weighted equally by access and quality of the financial services as the pillars. Further, the financial inclusion of SMEs is mainly determined by demand-side factors (ability to manage economic changes, proffer record keeping, and willingness to expand the business), supply-side factors (collateral requirements and application procedure), institutional factors (ownership type and sector of the firm), and some demographic characteristics of owner-manager of SMEs. The study recommends that the state bankers, commercial bankers, and policymakers should put in place policies that encourage financial service providers to set up their operations close and incorporate innovative approaches to ensure that they adopt technologies and financial services that are more accessible.
Paternal Expressed Gene 10 (PEG10) is decreased in early-onset preeclampsia
Authors: Baird Lydia , Cannon Ping , Kandel Manju , Nguyen Tuong-Vi , Nguyen Anna , Wong Georgia , Murphy Cíara , Brownfoot Fiona C. , Kadife Elif , Hannan Natalie J. , Tong Stephen , Bartho Lucy A. , Kaitu’u-Lino Tu’uhevaha J.
Published: July 2023

Background

Preeclampsia is a severe complication of pregnancy which is attributed to placental dysfunction. The retrotransposon, Paternal Expressed Gene 10 (PEG10) harbours critical placental functions pertaining to placental trophoblast cells. Limited evidence exists on whether PEG10 is involved in preeclampsia pathogenesis. This study characterised the expression and regulation of PEG10 in placentas from patients with early-onset preeclampsia compared to gestation-matched controls.

Methods

PEG10 expression was measured in plasma and placentas collected from patients with early-onset preeclampsia (< 34 weeks’) and gestation-matched controls using ELISA (protein) and RT-qPCR (mRNA). First-trimester human trophoblast stem cells (hTSCs) were used for in vitro studies. PEG10 expression was measured during hTSC differentiation and hTSC exposure to hypoxia (1% O2) and inflammatory cytokines (IL-6 and TNFα) using RT-qPCR. Functional studies used PEG10 siRNA to measure the effect of reduced PEG10 on canonical TGF-$$\beta$$
β
signalling and proliferation using luciferase and xCELLigence assays, respectively.

Results

PEG10 mRNA expression was significantly reduced in placentas from patients with early-onset preeclampsia (< 34 weeks’ gestation) relative to controls (p = 0.04, n = 78 vs n = 18 controls). PEG10 protein expression was also reduced in preeclamptic placentas (p = 0.03, n = 5 vs n = 5 controls, blinded assessment of immunohistochemical staining), but neither PEG10 mRNA nor protein could be detected in maternal circulation. PEG10 was most highly expressed in hTSCs, and its expression was reduced as hTSCs differentiated into syncytiotrophoblasts (p < 0.0001) and extravillous trophoblasts (p < 0.001). Trophoblast differentiation was not altered when hTSCs were treated with PEG10 siRNA (n = 5 vs n = 5 controls).

PEG10 was significantly reduced in hTSCs exposed to hypoxia (p < 0.01). PEG10 was also reduced in hTSCs treated with the inflammatory cytokine TNF $$\alpha$$
α
(p < 0.01), but not IL-6. PEG10 knocked down (siRNA) in hTSCs showed reduced activation of the canonical TGF-β signalling effector, the SMAD binding element (p < 0.05) relative to controls. PEG10 knockdown in hTSCs however was not associated with any significant alterations in proliferation.

Conclusions

Placental PEG10 is reduced in patients with early-onset preeclampsia. In vitro studies suggest that hypoxia and inflammation may contribute to PEG10 downregulation. Reduced PEG10 alters canonical TGF-$$\beta$$
β
signalling, and thus may be involved in trophoblast dysfunction associated with this pathway.
Endoplasmic reticulum stress: a novel targeted approach to repair bone defects by regulating osteogenesis and angiogenesis
Authors: Wu Tingyu , Jiang Yaping , Shi Weipeng , Wang Yingzhen , Li Tao
Published: July 2023

Bone regeneration therapy is clinically important, and targeted regulation of endoplasmic reticulum (ER) stress is important in regenerative medicine. The processing of proteins in the ER controls cell fate. The accumulation of misfolded and unfolded proteins occurs in pathological states, triggering ER stress. ER stress restores homeostasis through three main mechanisms, including protein kinase-R-like ER kinase (PERK), inositol-requiring enzyme 1ɑ (IRE1ɑ) and activating transcription factor 6 (ATF6), collectively known as the unfolded protein response (UPR). However, the UPR has both adaptive and apoptotic effects. Modulation of ER stress has therapeutic potential for numerous diseases. Repair of bone defects involves both angiogenesis and bone regeneration. Here, we review the effects of ER stress on osteogenesis and angiogenesis, with emphasis on ER stress under high glucose (HG) and inflammatory conditions, and the use of ER stress inducers or inhibitors to regulate osteogenesis and angiogenesis. In addition, we highlight the ability for exosomes to regulate ER stress. Recent advances in the regulation of ER stress mediated osteogenesis and angiogenesis suggest novel therapeutic options for bone defects.
Benzodiazepine use, quality of life and psychiatric symptom burden in oral and injectable opioid agonist treatment: a cross-sectional study
Authors: Meyer Maximilian , Gygli Ferdinand , Westenberg Jean N. , Schmid Otto , Strasser Johannes , Lang Undine E. , Dürsteler Kenneth M. , Vogel Marc
Published: July 2023

Background

Use of benzodiazepines (BZD) in patients receiving opioid agonist treatment (OAT) is common and associated with a variety of negative health and social outcomes. This cross-sectional study investigates the impact of BZD use in OAT patients on their quality of life (QoL).

Methods

A convenience sample of patients receiving oral OAT or heroin-assisted treatment in two outpatient centres in Basel, Switzerland was investigated. Participants (n = 141) completed self-report questionnaires on psychiatric symptoms and psychological distress (The Symptom Checklist 27, SCL-27), depressive state (German version of the Center for Epidemiological Studies Depression Scale), quality of life (Lancashire Quality of Life Profile, LQOLP) and use of BZD and other drugs (self-report questionnaire). Substance use was assessed by urine toxicology testing.

Results

In bivariate analysis, total QoL scores were significantly lower for lifetime, current, and prolonged BZD users compared to participants without the respective use patterns. There was no significant relationship between BZD dose and QoL. In multivariable linear regression models controlling for psychiatric symptom load and depressive state, only lifetime use predicted lower QoL, whereas other BZD use patterns were not significantly associated.

Conclusions

The association of lower QoL and BZD use in OAT patients is strongly confounded by co-occurring depressive state and psychiatric symptoms. Careful diagnosis and treatment of co-occurring mental disorders in OAT is paramount to improve QoL in this patient population and may also help reduce BZD use.
Integration of photogrammetry and laser scanning for enhancing scan-to-HBIM modeling of Al Ula heritage site
Authors: Alshawabkeh Yahya , Baik Ahmad
Published: July 2023

The study highlights the significance of combining imaging and laser scanning techniques to enrich point clouds used for reliable documentation and Heritage Building Information Modeling (HBIM). The fusion-based approach was used to document Al Ula Heritage site in Saudi Arabia, a UNESCO World Heritage Site with well-preserved tombs from the first century BC. The HBIM parametric modeling process requires a detailed survey to collect all geometric data. Although terrestrial laser scanners (TLS) are an efficient tool for 3D recording of heritage scenes in a short period of time, the data resolution is insufficient for identifying and evaluating the spatial distribution of surface weathering forms. Furthermore, combining scans collected at different times may pose difficulties in recording the texture. These issues have an impact on the subsequent 3D modeling phase as well as the efficiency of interpreting and tracing surface features in the Scan-to-BIM process. The proposed workflow using imagery data to enhance both the geometry and coloring of laser point clouds. In addition to texture mapping, the high-resolution imagery is used to densify the laser data using dense image matching, allowing for a clear reading of the surface features, and serving as a useful tool to identify the type, extent, and severity of façade damage. TLS and imagery data were collected separately, with images taken at the best time and location for realistically recording of surface details. Finally, the captured images are orthorectified by TLS geometric information and used for HBIM texturing to provide realistic decay mapping. The results showed that the combination of TLS and photogrammetry allowed for the efficient collection of 3D data, which improved tracing and digitizing HBIM with complete mapping information. The research findings will be greatly useful in the management and planning of historic building conservation and restoration projects.
Fibromyalgia with psoriatic and rheumatoid arthritis: relationship with disease activity and serum vitamin D level
Authors: Abozaid Hanan S. , Khalaf Alshimaa Hamdy , Elgendy Dalia S. , Ahmed Rabab Hussein Ali
Published: July 2023

Background

The study of the relationship between the presence of fibromyalgia (FM) with rheumatoid (RA) and psoriatic arthritis (PsA) patients can affect the main disease outcome and the treatment decision. The research aims to assess the associated fibromyalgia and vitamin D level in rheumatoid and psoriatic arthritis patients.

Results

A cross-sectional study included 60 RA, 30 PsA, and 40 healthy controls, all of them were evaluated for the diagnosis of FM and serum vitamin D level, disease activity score 28 (DAS28), and health quality of life. The mean age of RA was 47.75 ± 11.11 SD, for PsA 44.17 ± 10.8 SD, and for the controls 44.35 ± 13.64 with no significant differences. FM was diagnosed in 21.7% of RA, 13.3% of PsA, and 2.5% of healthy controls with a significant difference among the three groups (P value = 0.025). RA and PsA patients with concomitant FM showed statistically significant higher disease activity scores, significantly worse quality of life than those without FM, and significantly lower serum vitamin D than those without FM.

Conclusion

Vitamin D deficiency and the presence of FM can be related to higher disease activity and less response to treatment, early recognition and treatment of FM and vitamin D deficiency in RA and PsA patients could be important to obtain a good response to therapy and achieve remission.
Relato de Experiência: Escuta Clínica, HIV/AIDS e Covid-19
Authors: Soares Gilberta Santos
Published: July 2023

O artigo compartilha um relato de experiência de atendimento psicológico a pessoas que vivem com HIV/AIDS na pandemia causada pela covid-19, da Campanha Voluntariado pelas Américas Covid-19 e HIV/AIDS. A proposta busca colaborar com a tessitura de elaborações teóricas e técnicas sobre a escuta clínica, especialmente em sua forma remota. O atendimento psicológico virtual, de curta duração, foi realizado por 14 psicólogas voluntárias, a maioria ancorada na Psicanálise. A escuta orientou-se pela avaliação da angústia central a partir da queixa-sintoma, avaliando riscos, fatores estressantes e apoios. Amparou-se na noção de clínica ampliada, na articulação com as ações da campanha relacionadas à falta de medicamentos e à carência de alimentos, com encaminhamentos para a rede de atenção à saúde. Considerou o sofrimento psíquico associado a vulnerabilidades socioeconômicas a partir do dispositivo da necropolítica. O sofrimento emocional foi atravessado pelo adoecimento físico, por questões relativas à covid-19, e pela atualização de sentimentos vivenciados com o HIV, tais como: não aceitação do diagnóstico, medo da morte, abandono, isolamento e estigmas. Conclui-se que a escuta psicológica deu suporte emocional às pessoas em momento de intenso sofrimento psíquico. A empatia, o afeto e a solidariedade foram teias de resistência no momento de crise sanitária.
Motion screening of fiducial marker for improved localization precision and resolution in SMLM
Authors: Li Kaiyuan , Ni Jielei , Tan Xiao , Zhou Qianwen , Chen Danni , Cao Bo , Lin Jiafan , Lin Ting , Zhao Pengxiang , Yuan Xiaocong , Ni Yanxiang
Published: July 2023

Single-molecule localization microscopy (SMLM) provides unmatched high resolution but relies on accurate drift correction due to the long acquisition time for each field of view. A popular drift correction is implemented via referencing to fiducial markers that are assumed to be firmly immobilized and remain stationary relative to the imaged sample. However, there is so far lack of efficient approaches for evaluating other motions except sample drifting of immobilized markers and for addressing their potential impacts on images. Here, we developed a new approach for quantitatively assessing the motions of fiducial markers relative to the sample via mean squared displacement (MSD) analysis. Our findings revealed that over 90% of immobilized fluorescent beads in the SMLM imaging buffer exhibited higher MSDs compared to stationary beads in dry samples and displayed varying degrees of wobbling relative to the imaged field. By excluding extremely high-MSD beads in each field from drift correction, we optimized drift correction and experimentally measured localization precision. In SMLM experiments of cellular microtubules, we also found that including only relatively low-MSD beads for drift correction significantly improved the image resolution and quality. Our study presents a simple and effective approach to assess the potential relative motions of fiducial markers and emphasizes the importance of pre-screening fiducial markers for improved image quality and resolution in SMLM imaging.
Performing High-Quality, Safe, Cost-Effective, and Efficient Basic Colonoscopy in 2023: Advice From Two Experts
Authors: Anderson Joseph C. , Rex Douglas K.
Published: July 2023

Based on published evidence and our expert experience, we provide recommendations to maximize the efficacy, safety, efficiency, and cost-effectiveness of routine colonoscopy. High-quality colonoscopy begins with colon preparation using a split or same-day dose and preferably a low-volume regimen for optimal patient tolerance and compliance. Successful cecal intubation can be achieved by choosing the correct colonoscope and using techniques to facilitate navigation through challenges such as severe angulations and redundant colons. Safety is a primary goal, and complications such as perforation and splenic rupture can be prevented by avoiding pushing through fixed resistance and avoiding loops in proximal colon. Furthermore, barotrauma can be avoided by converting to water filling only (no gas insufflation) in every patient with a narrowed, angulated sigmoid. Optimal polyp detection relies primarily on compulsive attention to inspection as manifested by adequate inspection time, vigorous probing of the spaces between haustral folds, washing and removing residual debris, and achieving full distention. Achieving minimum recommended adenoma detection rate thresholds (30% in men and 20% in women) is mandatory, and colonoscopists should aspire to adenoma detection rate approaching 50% in screening patients. Distal attachments can improve mucosal exposure and increase detection while shortening withdrawal times. Complete resection of polyps complements polyp detection in preventing colorectal cancer. Cold resection is the preferred method for all polyps < 10 mm. For effective cold resection, an adequate rim of normal tissue should be captured in the snare. Finally, cost-effective high-quality colonoscopy requires the procedure not be overused, as demonstrated by following updated United States Multi Society Task Force on Colorectal Cancer postpolypectomy surveillance recommendations.
The Comparative Effectiveness of Ciprofloxacin and Metronidazole for an Initial Episode of Pouchitis: A Propensity-Matched Study
Authors: Barnes Edward L. , Desai Aakash , Kochhar Gursimran S.
Published: July 2023

INTRODUCTION:

There is minimal evidence regarding the comparative effectiveness of individual antibiotics in the treatment of pouchitis. We sought to evaluate the comparative effectiveness of ciprofloxacin monotherapy, metronidazole monotherapy, and combination therapy (ciprofloxacin and metronidazole) in the treatment of an initial episode of pouchitis after ileal pouch-anal anastomosis for ulcerative colitis (UC).

METHODS:

We performed a retrospective cohort study in TriNetX, a global federated research network of electronic health records. Primary outcomes were failure of initial antibiotic therapy and the development of recurrent pouchitis in the first 12 months after an initial episode of pouchitis. One-to-one propensity score matching was performed for age, sex, race, primary sclerosing cholangitis, nicotine dependence, obesity, and previous exposure to tumor necrosis factor inhibitors between the cohorts.

RESULTS:

Among 271 patients who developed pouchitis (mean age at ileal pouch-anal anastomosis 35.8 years, male sex 57%) and were treated with ciprofloxacin, metronidazole, or combination therapy, 190 (70%) developed recurrent pouchitis. After propensity score matching, there was no significant difference in the odds of early relapse or nonresponse with ciprofloxacin compared with metronidazole monotherapy (adjusted odds ratio 0.56, 95% confidence interval 0.23–1.34) or when either monotherapy was compared with combination therapy. There was also no significant difference in odds of recurrent pouchitis when comparing patients treated with ciprofloxacin with metronidazole monotherapy (adjusted odds ratio 0.86, 95% confidence interval 0.40–1.84) or either monotherapy with combination therapy.

DISCUSSION:

In this retrospective cohort study, we demonstrated no significant difference in the real-world effectiveness of ciprofloxacin, metronidazole, or combination therapy for the initial episode of pouchitis.
EVALUATING THE COMPLEXITY OF GENE COEXPRESSION ESTIMATION FOR SINGLE-CELL DATA
Authors: Zhang Jiaqi , Singh Ritambhara
Published: July 2023

With the rapid advance of single-cell RNA sequencing (scRNA-seq) technology, understanding biological processes at a more refined single-cell level is becoming possible. Gene coexpression estimation is an essential step in this direction. It can annotate functionalities of unknown genes or construct the basis of gene regulatory network inference. This study thoroughly tests the existing gene coexpression estimation methods on simulation datasets with known ground truth coexpression networks. We generate these novel datasets using two simulation processes, NORmal-To-Anything (NORTA) and Single-cell ExpRession of Genes In silicO (SERGIO), that use the parameters learned from the experimental data. We demonstrate that these simulations better capture the underlying properties of the real-world single-cell datasets than previously tested simulations for the task. Our performance results on tens of simulated and eight experimental datasets show that all methods produce estimations with a high false discovery rate, potentially caused by high sparsity levels in the data. Finally, we find that commonly used preprocessing approaches, such as normalization and imputation, do not improve the coexpression estimation. Overall, our benchmark setup contributes to the coexpression estimator development, and our study provides valuable insights for the community for single-cell data analyses.
Writing Londinium with the Five Senses
Authors: Lawrence Caroline Day
Published: July 2023

In this paper, children's author Caroline Lawrence shares specific examples of how she gets inspiration for her historical novels by using the five senses. Based on a practical session during a conference on sensory archaeology, she writes about visiting museums and reenactment events, handling real and replica objects and trying to find other sensory links to the ancient world. Visual inspirations include the bones of the so-called Lant Street Teen from a Roman graveyard in Southwark, an ivory and iron knife buried with her and leather bikini bottom from a Roman era well. Bay leaves, frankincense and mastic have been found in Roman graves and along with the fishy scent of garum they provide olfactory inspiration. During the conference attendees chewed mastic gum, scraped scented oil off their forearms with a replica strigil and sipped posca: water diluted with vinegar. After several other practical examples, Caroline concludes with a purely imaginary guided meditation. 
Predictors of fluid responsiveness in the operating room: a narrative review
Authors: Oh Ah Ran , Lee Jong-Hwan
Published: July 2023

Prediction of fluid responsiveness has been considered an essential tool for modern fluid management. However, most studies in this field have focused on patients in intensive care unit despite numerous research throughout several decades. Therefore, the present narrative review aims to show the representative method’s feasibility, advantages, and limitations in predicting fluid responsiveness, focusing on the operating room environments. Firstly, we described the predictors of fluid responsiveness based on heart-lung interaction, including pulse pressure and stroke volume variations, the measurement of respiratory variations of inferior vena cava diameter, and the end-expiratory occlusion test and addressed their limitations. Subsequently, the passive leg raising test and mini-fluid challenge tests were also mentioned, which assess fluid responsiveness by mimicking a classic fluid challenge. In the last part of this review, we pointed out the pitfalls of fluid management based on fluid responsiveness prediction, which emphasized the importance of individualized decision-making. Understanding the available representative methods to predict fluid responsiveness and their associated benefits and drawbacks through this review will aid anesthesiologists in choosing the most reliable methods for optimal fluid administration in each patient during anesthesia in the operating room.
Riqueza y distribución de licopodios y helechos del Parque Nacional El Chico, estado de Hidalgo, México
Authors: Serrano-Martínez Héctor , Ortiz-Quijano Adriana Beatriz , Tejero-Díez José Daniel , Sánchez-González Arturo
Published: July 2023

Antecedentes: El Parque Nacional El Chico (PNC), una de las primeras áreas naturales protegidas (ANP) en México, es relevante por los servicios ambientales y biodiversidad que alberga, por lo que es necesario conocer su flora.
Preguntas: ¿Cuál es la riqueza y distribución de licopodios y helechos en los diferentes tipos de vegetación del PNC? ¿Cómo es la diversidad beta, en ambos grupos de plantas en el PNC, con respecto a otras ANP del estado de Hidalgo?
Especies de estudio: Helechos y licopodios
Sitio y años de estudio: Parque Nacional El Chico, 2008-2009, 2022
Métodos: Se recolectaron ejemplares en 18 localidades y siete tipos de vegetación y se determinaron a nivel de especie. Se estimó diversidad taxonómica, semejanza en composición de especies, diversidad beta y complementariedad, con técnicas estándar.
Resultados: Se recolectaron 205 ejemplares que representan 63 especies de helechos y cinco de licopodios. Las familias representativas fueron Aspleniaceae, Dryopteridaceae, Polypodiaceae, Pteridaceae y Selaginellaceae (> 5 especies cada una). La riqueza fue alta en los bosques de Abies-Quercus, galería, Quercus y Abies (> 22 especies en cada uno). El número de especies por unidad de área fue elevado, comparado con otras ANP y regiones aledañas; la complementariedad fue alta con respecto a las dos ANP de mayor extensión territorial en Hidalgo.
Conclusiones: El PNC alberga 60.2 % de las especies de licopodios y helechos de la cuenca de México, y presenta alta diversidad taxonómica y complementariedad, comparado con otras ANPs de la entidad, lo cual resalta su importancia como reservorio de biodiversidad.
“When I think about my future, I just see darkness”: How youth exiting homelessness navigate the hazy, liminal space between socioeconomic exclusion and inclusion
Authors: Thulien Naomi S. , Hwang Stephen W. , Kozloff Nicole , Nisenbaum Rosane , Akdikmen Alex , Fambegbe Oluwapelumi , Feraday Robyn , Mathewson Caitlin , Mutamiri Matthew , Roglich Julia , Wang Andrea , Zagala Micah , Amiri Alexandra
Published: July 2023

Objectives

The overarching objective of this mixed methods longitudinal study was to understand whether and how rent subsidies and mentorship influenced socioeconomic inclusion outcomes for youth exiting homelessness. The focus of this paper is on the qualitative objectives, which evolved from a primary focus on exploring how study mentorship was working as a facilitator of socioeconomic inclusion to focusing on how participants navigated the hazy, liminal space between socioeconomic exclusion and inclusion.

Methods

This was a convergent mixed methods study scaffolded by community-based participatory action axiology. The quantitative component is reported elsewhere and involved a 2-year pilot randomized controlled trial where 24 participants received rent subsidies and 13 were randomly assigned a study mentor; proxy indicators of socioeconomic inclusion were measured every 6 months for 2.5 years. Qualitative objectives were explored using a qualitative descriptive design and theoretically framed using critical social theory. The lead author interviewed 12 participants every 6 months for 2.5 years. Qualitative interviews were analyzed using reflexive thematic analysis with an emphasis on critical interpretation.

Results

Navigating the liminal space between socioeconomic exclusion and inclusion was complex and non-linear, and the way youth navigated that journey was more strongly associated with factors like informal mentorship (naturally occurring “coach-like” mentorship) and identity capital (sense of purpose, control, self-efficacy, and self-esteem), rather than whether or not they were assigned a formal study mentor.

Conclusion

A holistic approach integrating coaching and attention to identity capital alongside economic supports may be key to helping youth exiting homelessness achieve socioeconomic inclusion.
Olfactory mucosa sampling and processing v1
Authors: not provided maria.xylaki
Published: July 2023

This protocol describes the olfactory mucosa sampling and processing for RT-QuIC assays and was adapted from A. Stefani et al. (doi:10.1093/brain/awab005).
20 minute PCR Enzymatic Cleanup v1
Authors: Liber Julian
Published: July 2023

A rapid microplate-compatible protocol for cleanup of PCR products prior to Sanger sequencing. Verify that the PCR produces a single band, and retain some PCR product for cleanup and sequencing. Set up at room temperature, and react on the thermocycler. Mechanism: PCR products contain 1) primers and 2) dNTPs which will interfere with downstream Sanger sequencing reactions. Exonuclease I degrades ssDNA (primers) and calf intestinal phosphatase degrades dNTPs. Functions like NEB #E1050.
Bütün Parçaların Toplamından Daha Fazladır: Eğitim Bilimlerinde Sistematik Derleme Nasıl Yazılır?
Authors: İLGÜN DİBEK Münevver , TOPTAŞ Burcu
Published: July 2023

Sosyal bilimlerde her geçen gün artan araştırmalar, araştırmacılara farklı bağlamlarda karşılaştırmalı çalışmalar yapma fırsatı sunmaktadır. Araştırma sayısı arttıkça hem araştırmacılar hem uygulayıcılar, müdahale programlarının (uygulamaların) etkililiğinin ne olduğu konusunda çelişkiye düşmektelerdir. Nitekim sonuçlar karmaşık, tutarsız ya da çelişkili olabilmektedir. Bu noktada, araştırmalar üstü çalışmaların yapılmasına gerek duyulmaktadır. Bu çalışmanın amacı sistematik derlemelerin eğitim bilimlerinde kullanımı hakkında bilgi vermektir. Sistematik derlemeler, araştırmacılara, politika yapıcılara ve uygulayıcılara bir konuda derinlemesine ve detaylı sonuçlar sunmaktadır. Bu çalışmada sistematik derlemenin tanımı, eğitim bilimlerinde kullanımı ve aşamaları alanyazındaki tartışmalar ışığında derlenmiştir. Buna göre sistematik derlemenin üç aşamasından söz edilebilir. Bu aşamalar; derlemenin tasarlanması, arama ve tarama ile derlemenin raporlaştırılmasıdır. Sistematik derleme tasarlanırken dikkat edilmesi gereken bazı yanlılık türleri vardır. Bu yanlılık türleri ise seçim, basım, gecikme, seçici sonuç raporlama, yanlılık riski değerlendirmesinin azlığı, dil, duplikasyon ve veritabanı yanlılığıdır. Sistematik derleme hazırlanırken çeşitli yazılımlar ve platformalardan yararlanılabilir; ancak özellikle yanlılık oluşmaması açısından bunların dikkatli kullanılması gerekmektedir.
Assessing Older Adults’ Perspectives on Digital Game-Related Strategies to Foster Active and Healthy Ageing
Authors: Regalado Francisco , Ortet Cláudia Pedro , Costa Liliana Vale , Santos Carlos , Veloso Ana Isabel
Published: July 2023

The growing use of digital platforms among older adults has brought increased challenges to the design and development process, thus requiring considering age-related needs and changes. Nonetheless, a growing body of research suggests that different types of applications of digital platforms, i.e., digital games, can foster new opportunities to encourage active and healthy ageing (AHA) by promoting knowledge acquisition, developing competences, fostering well-being, and deepening social connections. Therefore, this study aims to assess older adults’ perspectives and participation in digital game-related strategies and how these can foster AHA. A mixed-methods approach was applied, resorting to field notes and a questionnaire, involving 18 participants aged between 63 and 81, at the Ageing Lab (Laboratório do Envelhecimento). Through 10 exploratory digital gaming-related sessions over approximately two months, participants were introduced to game-related strategies and online communities. Overall, this study sustained previous research about the influence of digital games and online communities in the promotion of AHA, by encouraging participation in society, acquisition of new digital competences in the dimensions of information and data literacy, communication and collaboration, and safety; and maintaining one’s health and well-being. Moreover, findings suggest that continued contact with information and communication technologies stimulates digital proficiency, thus further fostering inclusion in an increasingly digital society.
Preliminary Results from a Dense Short-Period Seismic Deployment around the Source Zone of the 1886 M 7 South Carolina Earthquake
Authors: Chen William , Neves Miguel , Zhai Qiushi , Daniels Clara , Adeboboye Oluwaseyifunmi , Jaume Steven , Peng Zhigang
Published: July 2023

The 1886 magnitude ∼7 Summerville, South Carolina, earthquake was the largest recorded on the east coast of the United States. A better understanding of this earthquake would allow for an improved evaluation of the intraplate seismic hazard in this region. However, its source fault structure remains unclear. Starting in May 2021, a temporary 19-station short-period seismic network was deployed in the Summerville region. Here, we present our scientific motivation, station geometry, and quality of the recorded seismic data. We also show preliminary results of microearthquake detections and relocations using recordings from both our temporary and four permanent stations in the region. Starting with 52 template events, including two magnitude ∼3 events on 27 September 2021, we perform a matched filter detection with the one year of continuous data, resulting in a catalog of 181 total events. We then determine precise relative locations of a portion of these events using differential travel-time relocation methods, and compare the results with relocation results of 269 events from a previous seismic deployment in 2011–2012. We also determine focal mechanism solutions for three events from 27 September 2021 with magnitudes 2.0, 3.1, and 3.3, and infer their fault planes. Our relocation results show a south-striking west-dipping zone in the southern seismicity cluster, which is consistent with the thrust focal mechanism of the magnitude 3.3 earthquake on 27 September 2021 and results from the previous study based on the temporary deployment in 2011–2012. In comparison, the magnitudes 3.1 and 2.0 events likely occur on a north–south-striking right-lateral strike-slip fault further north, indicating complex patterns of stress and faulting styles in the region.
Aphorisms of Dr. Rosenthal (Part II)
Authors: Semenova Natalya V.
Published: July 2023

The aphorisms of the journalist, publicist, physician August Osipovich Rosenthal (18301891) are introduced into scientific discourse. In 1855 Rosenthal raised an uprising that became part of the peasant uprisings of the mid-1850s. He was arrested and exiled to Siberia, later reinstated. In 1880 he emigrated: the published aphorisms refer to the overseas period of Rosenthal's life. The preamble to the text specifies biographical information based on archival sources from Rosenthal's personal fund (Manuscript Department of the IRLI (the Pushkin House) RAS, F. 258).The published aphorisms are reflections on the moral nature of the human being and society. Distinctive features of Rosenthal's collection are a combination of didactics, humor and adherence to the knowledge scientific paradigm, openness to dialogue with the reader and declarative interactivity.
Infants in the digital reality
Authors: Bylieva Daria S.
Published: July 2023

The source of the formation of basic skills for young children is the environment that is created by surrounding adults. Modern children are introduced and seduced by mobile devices in infancy. Most often, parents use gadgets as a universal way to calm or entertain the child in order to save time for work or leisure. Touch screens and visual interfaces allow young children to interact with devices in a more responsive way than it is possible in the physical world. The experiences gained in the digital reality is carried over to the offline world, from the naive ways of interacting with the physical reality, demonstrated by infants, to the transfer of such of behavior norms as the ability to return and undo actions. The knowledge and skills related to digital resources and games are becoming more important than knowledge about the surrounding world. Voice assistants not only allow children to use the Internet without being literate, but also actively interact with the infant as a babysitter. Such communication allows children to draw a conclusion about their anthropomorphism, and, in general, contributes to uncritical immersion in the digital reality much earlier, than they are able to comprehend and realize it that dictates new ways of existence. Such an early and positive acquaintance with digital technologies gives the new generation trust and confidence in the inviolability of the technogenic world
The specifics of digital business communication at Chinese enterprises
Authors: Zhao Yunhui
Published: July 2023

The article discusses the features of business communication in digital format on the example of Chinese enterprises. In the course of the study, various electronic communication tools used in business communication were studied. The advantages and disadvantages of each of the methods of digital communication are determined. The specific characteristics of the business style of communication are described. Chinese enterprises experience demonstrates the advantages of the digital format of business communication.
Endogenous PTHrP C-terminus antagonises Bglap towards a non-canonical pathway by stimulating Wnt signalling independently of OSE2 element and PTH1R/PKA signalling
Authors: Sun Sylvia , Ho Patricia , Irwin Blessing , Martin T J , Sims Natalie
Published: July 2023

The authors have requested that this preprint be removed from Research Square.
Autophagy related gene CEP55 is a potential biomarker for osteoarthritis
Authors: Li Qiang , Hu Yong
Published: July 2023

Objective
To screen the target autophagy related genes that may play an important role in the development of osteoarthritis.
Methods
We analyzed the differentially expressed genes between osteoarthritis samples and control samples in the online dataset GSE46750. We compared these differential genes with autophagy database, and screened out autophagy genes whose expression levels changed significantly in the process of osteoarthritis.We found the Hub gene in these autophagy related genes by constructing a protein interaction network, and analyzed the potentiality of these genes to distinguish patients with osteoarthritis, and constructed the interaction network between these genes and miRNA, further clarifying their potential functions.
Results
Compared with the control group, the expression of 105 autophagy related genes in Osteoarthritis tissue samples was significantly different. Among these 105 autophagy related genes, 15 Hub genes(AURKA,BIRC5,BUB1,CDC20,CEP55,FOXM1,KIFC1,MAD2L1,MCM2,MCM4,MCM5,RACGAP1,CDCA3,OIP5 and LMNB1) are located at the core of the protein interaction network.The expression level of these Hub genes can distinguish Osteoarthritis tissue samples from control samples, in which CEP55 can be a reliable marker for distinguishing OA from normal individuals,and it also can regulate the expression of miRNA, so CEP55 may be a good target for the treatment of OA by regulating the autophagy level.
Conclusion
In the development of Osteoarthritis, there is a regulatory network of autophagy related genes. CEP55 is a key gene regulating autophagy process, and it has the potential to interact with miRNA.
Effect of Meteorological Parameters and Air Pollutants Association with Health Risk Assessment during the Pandemic in Delhi, India
Authors: Singh Bhupendra Pratap , Mehra Kriti , Chowdhary Khyati , Khanna Charvi , Chandra Prakash
Published: July 2023

The novel Coronavirus disease was reported in the last week of December 2019 in the capital of Hubei province, Wuhan, China, which outspread in no time and hit more than 210 countries, including India. A considerable recovery in the air conditions during the lockdown occurred due to substantial reduction measures in all the activities throughout the pandemic. The present study evaluated the changes in particulate pollutants and the role of meteorological parameters during the course of the pandemic. The mean concentrations of PM2.5 and PM10 for all monitoring bases were calculated to be 109.54 and 214.04 µg/m3 for the years 2019–2021, respectively. The average values for PM2.5 and PM10 for all monitoring stations were observed to be 113.33, 108.92, 106.92 µg/m3, and 221.34, 203.02, 220.04 µg/m3 for the years 2019, 2020, and 2021 respectively. The gradual decline in values of PM2.5 has witnessed the closures of transport, industrial, and construction activities during the lockdown period in the year 2020. A strong significant positive correlation for PM2.5 was found between Alipur with ITO (0.89), Okhla (0.93), Narela (0.97), and Wazirpur (0.90), whereas PM10 was Alipur with ITO (0.82), Okhla (0.90), Narela (0.95), and Wazirpur (0.89), respectively. The present study investigated the relationship between PM2.5, PM10, meteorological parameters, and associated health risks. The negative relationships were observed between PM2.5 with temperature, wind speed, and solar radiation and a positive relationship with moisture and wind direction, whereas similar results were reported for PM10 for all monitoring stations. This study highlights that large emission reductions in the non-essential services were responsible for increasing the level of air quality. The health risk assessment for all age groups was calculated for pre-, during, and post-pandemic periods. The results for HQ values for PM2.5 indicated that children and infants were more likely to experience health effects after adults.
Data-Driven Invariant Learning for Probabilistic Programs
Authors: Bao Jialu Bao Jialu , Trivedi Nitesh Trivedi Nitesh , Pathak Drashti Pathak Drashti , Hsu Justin Hsu Justin , Roy Subhajit Roy Subhajit
Published: July 2023

Morgan and McIver’s weakest pre-expectation framework is one of the most well-established methods for deductive verification of probabilistic programs. Roughly,the idea is to generalize binary state assertions to real-valued expectations, whichcan measure expected values of probabilistic program quantities. While loop-freeprograms can be analyzed by mechanically transforming expectations, verifyingloops usually requires finding an invariant expectation, a difficult task.We propose a new view of invariant expectation synthesis as a regression prob-lem: given an input state, predict the average value of the post-expectation inthe output distribution. Guided by this perspective, we develop the first data-driven invariant synthesis method for probabilistic programs. Unlike prior workon probabilistic invariant inference, our approach can learn piecewise continuousinvariants without relying on template expectations. We also develop a data-driven approach to learn sub-invariants from data, which can be used to upper-or lower-bound expected values. We implement our approaches and demonstratetheir effectiveness on a variety of benchmarks from the probabilistic programmingliterature.