bluuebunny/crossref_metadata_2025 huggingface dataset:
An Atypical Ramsay-Hunt Syndrome: Case Report
Authors: Amine Ennaciri Mohamed , Sakina El Khaoua , Rime Baba , Youssef Zemmez , Mohamed El Amraoui , Rachid Frikh , Naoufal Hjira
Published: December 2024

After the initial infection, which manifests as varicella, the varicella-zoster virus (VZV) remains dormant in the sensory nerve ganglia. It reactivates in elderly people or in immunocompromised patients. When this reactivation involves the geniculate ganglion, it typically causes the Ramsay-Hunt syndrome manifesting as shingles in the Hunt’s zone which includes the eardrum, the external auditory canal and the cavum conchae, as well as a peripheral facial nerve palsy, earache and sensitivity or sensorial disturbances of the nearby cranial ans spinal nerves. Our case describes a 40-year-old patient who developed an atypical Ramsay-Hunt syndrome associating only peripheral facial nerve paralysis and a herpetiform vesiculopustular rash in the retroauricular area, with no otologic, vestibular or sensory signs. In fact, there are anastomoses between the different cranial nerve fibers and ganglia with the spinal nerves and ganglia, which may explain the occurrence of herpes zoster in the C2 dermatome with peripheral facial nerve palsy.
Dermoscopic Changes of a Cutaneous Leishmaniasis Treated with Intralesional Pentavalent Antimonials: A Case Report
Authors: Amine Ennaciri Mohamed , Rime Baba , Tarik Hanafi , Jawad El Azhari , Youssef Zemmez , Mohamed El Amraoui , Rachid Frikh , Naoufal Hjira
Published: December 2024

Leishmaniasis is a group of parasitic diseases caused by flagellated protozoa of the genus Leishmania with tropism for cells of the reticuloendothelial system, transmitted to many mammals by the bite of the sandfly. They can be visceral, cutaneous or mucocutaneous and represent a public health problem in countries where they are endemic. The diagnosis of cutaneous leishmaniasis is based on epidemiologic, clinical and dermoscopic evidence, with diagnostic certainty established by parasitologic examination, histology or PCR. Dermoscopic findings include erythema, starburst appearance, hyperkeratosis, central ulceration, yellow tears, salmon-colored ovoid structures, glomerular, linear, irregular, hairpin or arborizing vessels, and hypochromic perilesional halo. Pentavalent antimonials are used therapeutically in leishmaniasis, inhibiting ATP synthesis, fatty acids and glycolic oxidation, with immunostimulating and immunoregulatory properties. Our case is a cutaneous leishmaniasis treated with pentavalent antimonials, in which we monitored the dermoscopic appearance of the lesions as the sessions progressed. The salmon-colored ovoid structures were the first to disappear, followed by hyperkeratosis and erosion, then the initially polymorphic vascularization became monomorphic. Yellow tears and erythema were the last structures to disappear. Our article shows that the disappearance of certain structures and the appearance of others can be a good indicator of how close to healing the lesion is.
Metformin Induced Lichenoïd Drug Eruption
Authors: Amine Ennaciri Mohamed , Ghita Basri , Youssef Zemmez , Mohamed El Amraoui , Rachid Frikh , Naoufal Hjira , Nadia Tazi
Published: December 2024

Cutaneous lichenoid drug eruptions are rare adverse drug reactions reminiscent of lichen planus. The most frequently reported culprit drugs are Checkpoint inhibitors, tyrosine kinase inhibitors and TNF-α inhibitors, but other drugs can also be responsible. This case-report is about a 49-year-old woman with a history of type 2 diabetes. She started taking metformin 160 weeks before the onset of a pruritic lichenoid rash on the trunk and limbs, of which the histopathology was in favor of an adverse cutaneous lichenoid drug eruption caracterized by the presence of eosinophilic polynuclei in the perivascular infiltrate. The patient benefited from oral corticosteroids with discontinuation of metformin which resulted in the resumption of the lichenoid rash.
STUDENT ENROLMENT AND SECONDARY SCHOOL EFFICIENCY IN AKOKO NORTH EAST LOCAL GOVERNMENT AREA OF ONDO STATE
Authors: AKINDE DR. TEMILOLUWA MABEL
Published: December 2024

Student enrollment in educational institutions is a complex process influenced by various factors, known as enrollment variables. These factors, including socioeconomic conditions, access to amenities, geographical considerations, government policies, cultural norms, parental involvement, language barriers, and economic efficiency, collectively shape the educational landscape and contribute to the intricate dynamics of enrollment. Therefore, this study investigated student enrollment and secondary school efficiency in Akoko North East Local Government Area
of Ondo State. The research design for this study was descriptive research design of survey type.
The population of the study comprised all students. Self-designed questionnaire titled Students Enrollment Questionnaire (SEQ) and proforma were used to collect data. Three research questions were raised and answered with percentage, mean and standard deviation while one hypothesis was formulated and tested with Pearson Product Moment Correlation (PPMC) at 0.05 level of significance. The result revealed a positive and statistically significant correlation between student enrollment and school efficiency (r-cal = 0.657, r-tab = 0.236, p < 0.05). The study concluded that various factors, such as location and socioeconomic conditions, significantly impact student enrollment. Additionally, the level of efficiency in Akoko North East was found to be low. Based on the findings, the study recommends that schools should be built in each community to make education more accessible to students, thereby improving enrollment rates and overall educational efficiency.
The Moderating Role of Firm Size on the Relationship between Entrepreneurial Marketing and SMEs Performance in Bauchi State, Nigeria.
Authors: Zanab Tijjani , Usman, Umar , Muazu, Umar Adeiza
Published: December 2024

The research investigates the modifying role of a business's size on the connection between entrepreneurial marketing and SMEs' performance in Bauchi state. The exact goals were to: study the sway of pro-activeness on SMEs’ performance; investigate the sway of value creation on SMEs’ success; evaluate the modifying role of a business's size on the connection between proactiveness and SMEs’ performance; and identify the moderating role of a firm's size on the connection between value creation and SMEs’ performance in Bauchi state, Nigeria. The survey research obtained data using a five-point Likert-scale questionnaire, and the study population was 1,171 registered SMEs in Bauchi state. Following establishing a sample size of 298 using Taro Yamane's (1967) formula, questionnaires were sent to the managers or owners of the SMEs. Proactiveness (p-value: 0.004), value creation (p-value: 0.000), and firm size (p-value: 0.032; 0.003) all had a positive and significant impact on the performance of SMEs in Bauchi State, according to the study's findings, which were derived from a SEM analysis of the respondents' data using the Smart-PLS software version 4.1. The study concluded that entrepreneurial marketing strategies have statistical significance for the performance of SMEs in Bauchi State, Nigeria, and therefore recommends, among others, that SME owners and managers should always consider firm size when adopting entrepreneurial marketing strategies because firm size moderates the effect of proactiveness and value creation on SMEs performance in Bauchi State.
Gender Disparities in The Utilization of Digital Technology Among Science Teachers in Lagos State Secondary Schools
Authors: Oputa Grace Obyageli , A.L Dr. Adefuye, , Toyin Dahunsi Kehinde
Published: December 2024

This research explored the differences in digital technology usage among science teachers in secondary schools in Lagos State, focusing on gender disparities. A descriptive survey method was employed, utilizing a multistage sampling technique to purposively select 200 science teachers from the six educational districts of Lagos State. A questionnaire designed by the researcher was used as the primary tool to investigate gender disparities in digital technology utilization among science teachers. The reliability coefficient of the instrument was 0.78. Descriptive statistics were used to present demographic data, and mean values were applied to address the research questions. The hypotheses were tested using a T-test at a 0.05 significance level. The results indicated a significant difference in the use of digital technology among science teachers based on gender. Furthermore, the findings highlighted that digital technology enhances the effectiveness of science teachers by fostering creativity and innovation in their teaching practices. However, science teachers also encountered challenges when utilizing digital technology. The study underscored the importance of gender-specific attitudes and perceptions in influencing teachers' decisions on technology integration. It was recommended that policies and guidelines should be developed to promote gender equity in the use of technology in schools, which, in turn, could lead to greater student motivation and independence.
Pijat Oketani terhadap Kelancaran Produksi ASI Postpartum
Authors: Eveline Alfara Felia  , Yuliana Dewi , Lestari Yuli
Published: December 2024

Salah satu kegagalan pemberian ASI eksklusif dari faktor ibu adalah produksi ASI yang tidak lancar. Perawatan payudara yang dapat meningkatkan produksi ASI adalah dengan melakukan pijat laktasi seperti pijat oketani. Penelitian ini bertujuan untuk mengetahui pengaruh pijat oketani terhadap kelancaran produksi air susu ibu postpartum di Wilayah Kerja Puskesmas Gedung Negara Kabupaten Lampung Utara. Penelitian ini adalah penelitian kuantitatif, menggunakan Pre Eksperimental dengan pendekatan One Group pretest-posttest design. Jumlah sampel sebanyak 30 ibu postpartum dipilih dengan teknik purposive sampling. Instrumen penelitian menggunakan kuesioner produksi ASI. Pijat oketani selama 10-15 menit setiap pagi dan sore. Penelitian ini di analisis menggunakan Wilcoxon Signed Ranks Test. Hasil penelitian menunjukkan terdapat pengaruh pijat oketani terhadap kelancaran air susu ibu postpartum di wilayah kerja Puskesmas Gedung Negara Kabupaten Lampung Utara Tahun 2024 (p-value=0,000). Dapat disimpulkan bahwa pijat oketani dapat memperbaiki kelancaran produksi ASI. Maka, ibu diharapkan dapat menerapkan pijat oketani secara rutin sehingga produksi ASI semakin lancar.
Health Seeking Behaviour pada Pasien dengan Ulkus Diabetikum
Authors: Ardiyati Adelina Vidya , Ernawati Ernawati
Published: December 2024

Ulkus kaki diabetik merupakan salah satu komplikasi tersering pada pasien diabetes. Perilaku pencarian layanan kesehatan sangat penting untuk merencanakan perawatan dan manajemen diabetes setelah ditegakkan diagnosis sehingga komplikasi dapat diminimalkan. Tujuan dari penelitian ini adalah untuk melihat hubungan antara demografi dengan perilaku mencari penyembuhan ke fasilitas pelayanan kesehatan professional. Penelitian kuantitatif dengan desain analisis korelatif menggunakan rancangan penelitian cross-sectional. Total sampel sebanyak 112 subjek, pengumpulan data dilakukan dengan menggunakan instrumen Health Seeking Behaviour. Pasien ulkus diabetikum berjenis kelamin perempuan lebih banyak (60,7%), usia subjek terbanyak berada dalam rentang 35 sampai 60 tahun (75%), Status subjek yang sudah menikah sebanyak 78,5%. Terdapat hubungan yang signifikan antara Health Seeking Behaviour dan Persepsi manfaat, Persepsi hambatan, Persepsi keparahan, serta Persepsi kerentanan dengan p-value<0,05. Tenaga Kesehatan di klinik/rumah sakit agar dapat memberikan pendidikan kesehatan terkait penyakit ulkus diabetikum serta meningkatkan kesadaran mereka terhadap pentingnya mencari pertolongan penyembuhan ke fasilitas pelayanan kesehatan profesional.
PENGARUH PENGGUNAAN SMARTPHONE TERHADAP INTERAKSI SOSIAL DAN MINAT BELAJAR MAHASISWA PROGRAM STUDI PENDIDIKAN IPS
Authors: Rustantono Hendra , Puspita Elsa Dwi Puspita , Rasyid Hamidi Rasyid
Published: December 2024

Penelitian ini dilatarbelakangi oleh berkurangnya interaksi sosial mahasiswa program studi pendidikan IPS juga rendahnya minat belajar dalam lingkungan perkuliahan. Satu diantara faktor yang memberikan pengaruh rendahnya interaksi sosial dan minat belajar yakni penggunaan smartphone. Tujuan dari riset ini, yaitu untuk mengetahui pengaruh penggunaan smartphone terhadap interaksi sosial mahasiswa dan untuk mengetahui penggunaan smartphone terhaadap minat belajar mahasiswa program studi pendidikan IPS. Jenis risert ini termasuk dalam penelitian kuantitatif serta dilakukan di Universitas Islam Raden Rahmat Malang pada prodi Pendidikan IPS. Tehnik pengambilan data pada penelitian ini yakni mempergunakan observasi serta angket, sebagai alat ukurnya menggunakan skala likert. Hasil dari risert ini memperlihatkan bahwasanya, terdapat pengaruh penggunaan smartphone terhadap interaksi sosial dibuktikan melalui t-hitung = 4,820 > t-tabel = 1,669 dan signifikan = 0,000 < 0,05. Terdapat pengaruh penggunaan smartphone pada minat belajar dibuktikan dengan t-hitung = 2,779 > t-tabel = 1,669 juga signifikan = 0,007 < 0,05. Terdapat pengaruh linear penggunaan smartphone pada interaksi sosial dan minat belajar. Hal ini dapat dibuktikan dengan f-hitung = 21,545 > f-tabel = 3,984. Pengaruh penggunaan smartphone pada interaksi sosial dan minat belajar yakni sebesar 37,4%.
PENGEMBANGAN MEDIA PEMBELAJARAN BAHASA INDONESIA BERBASIS KOMIK PADA MATERI MENGANALISIS TEKS NEGOSIASI KELAS X SMK
Authors: Zega Yathree Warni , Harefa Trisman
Published: December 2024

Berlangsungnya kegiatan pembelajaran yang baik dalam kelas diakibatkan adanya interaksi yang baik antara guru dengan peserta didik untuk saling bertukar informasi. Pada kegiatan pembelajaran guru diharapkan mampu memanfaatkan dan mengembangkan media pembelajaran sehingga kegiatan pembelajaran dapat berlangsung dengan baik. Namun kenyataannya,  guru di SMKN 1 Gunungsitoli masih menggunakan media pembelajaran yang tidak bervariasi secara khusus dalam pembelajaran bahasa indonesia. Tujuan dari penelitian ini adalah untuk mengembangakna media pembelajaran berbasis komik pada materi menganalisis struktur dan kebahasaan teks negosiasi di kelas X SMK yang valid, praktis, dan efektif. Pengembangan media pembelajaran berbasis komik menggunakan model pengembangan 4D dengan 4 tahapan yaitu: pendefinisian (defines), perancangan (design), pengembangan (develop), dan penyebaran (disseminate). Berdasarkan hasil penelitian, media pembelajaran berbasis komik yang dikembangkan telah teruji sangat valid dan layak oleh validator ahli. Validasi ahli materi mencapai 86,3% dengan kategori sangat layak, validasi ahli bahasa memperoleh nilai 100%, dan hasil validasi ahli desain sebesar 93,3%. Selanjutnya, kepraktisan media pembelajaran berbasis komik sangat praktis digunakan dengan persentase kepraktisan pada uji perorangan sebesar 86,7%, uji kelompok kecil sebesar 93,3%, dan uji lapangan sebesar 93,3%. Media pembelajaran komik juga telah teruji sangat efektif digunakan dengan persentase ketuntasan klasikal 85%. Berdasarkan hasil penelitian di atas, maka media pembelajaran yang telah dikembangkan dengan model pengembangan 4D  telah memenuhi tujuan penelitian.
Kata kunci: media pembelajaran komik, 4D, valid, praktis, efektif
PENERAPAN MODEL PEMBELAJARAN NUMBEREAD HEAD TOGETHER DALAM MENINGKATKAN HASIL BELAJAR SISWA
Authors: Zebua Pertahankan Sejahtera , Laoli Eka Septianti
Published: December 2024

Penelitian ini dilatar belakangi oleh pengamatan peneliti pada pelaksanaan pembelajaran di UPTD SMP Negeri 2 Mandrehe Barat, yang selama ini mengalami hambatan dalam prosesnya Penelitian ini bermaskud untuk memperoleh informasi Penerapan Model Pembelajaran Treffinger terhadap hasil belajar siswa Kelas VIII UPTD SMP Negeri 2 Mandrehe Barat. Jenis penelitian ini adalah Penelitian Tindakan Kelas (PTK). Populasi dalam penelitian ini adalah siswa UPTD SMP Negeri 2 Mandrehe Barat yaitu Kelas VIII/B berjumlah 21 orang. Instrument yang digunakan berupa lembar observasi, tes hasil belajar  dan dokumentasi. Dalam pelaksanaan ini Peneliti berkolaborasi dengan guru mata pelajaran, penulis sebagai pelaksana kegiatan penelitian, sedangkan guru mata pelajaran berfungsi sebagai pengamat.  Berdasarkan hasil penelitian, Pada siklus I hasil lembar observasi guru rata-rata mencapai 52,5% dan pada siklus II mengalami peningkatan menjadi 90,00%. Demikian juga pada hasil lembar observasi siswa, pada siklus I rata-rata 48,87% dan pada siklus II mengalami peningkatan signifikan dengan rata-rata mencapai 86,63%. Dari tes hasil belajar siklus I diperoleh data dan diolah sebagai hasil penelitian diperoleh rata-rata mencapai 72,95%, presentase ketuntasan hasil belajar siswa siklus I sebesar 66,67%, dan pada tes hasil belajar siklus II diperoleh data dan diolah sebagai hasil penelitian mencapai 81,06%, ditentukan presentase ketuntasan siswa pada siklus II sebesar 95,23%. Disimpulkan bahwa ada peningkatan hasil belajar siswa melalui Penerapan Model Pembelajaran Numbered Head Together di kelas VIII UPTD SMP Negeri 2 Mandrehe Barat Tahun Pelajaran 2022/2023
PENINGKATAN HASIL BELAJAR IPS MELALUI STRATEGI PEMBELAJARAN EVERYONE IS A TEACHER HERE SISWA KELAS V SD
Authors: Welu Feliks
Published: December 2024

Tujuan penelitian tindakan kelas ini adalah untuk mengetahui apakah strategi pembelajaran Everyone Is A Teacher Here dapat meningkatkan partisipasi belajar IPS siswa Kelas VA SDN 13 Ende. Penelitian ini menggunakan pendekatan kualitatif untuk mendapatkan data dan analisisnya melalui kajian-kajian reflektif, partisipatif dan kolaboratif. Pengembangan program didasarkan data-data dan informasi dari siswa, guru dan setting sosial kelas secara alamiah melalui tiga tahapan siklus penelitian tindakan kelas. Maka prosedur pelaksanaan penelitian tindakan kelas ini meliputi: (1) perencanaan, (2) pelaksanaan tindakan, (3) observasi, dan (4) refleksi dalam setiap siklus. Hasil penelitian menunjukkan bahwa strategi pembelajaran Everyone Is A Teacher Here terbukti dapat meningkatkan partisipasi belajar IPS siswa kelas VA SDN Ende13. Partisipasi siswa pada refleksi awal sebesar 50,87% siklus pertama, pada siklus kedua 63,75% dan siklus ketiga 76,07%. Prosesntase ini menunjukkan bahwa selama proses pembelajaran terjadi peningkatan 10% setiap siklus partisipasi belajar IPS pada siswa VA SDN Ende13 Berdasarkan analisis hasil penelitian tersebut, maka peneliti merefleksi bahwa strategi pembelajaran Everyone Is A Teacher Here ini dapat meningkatkan partisipasi belajar siswa.
PENGEMBANGAN KREATIVITAS SISWA KELAS VB MELALUI PEMBELAJARAN AKTIF TIPE CARD SORT PADA SISWA SDI ONEKORE 3
Authors: Sadipun Berty
Published: December 2024

Peneitian ini bertujuan untuk mengetahui apakah pembelajaran PPPKn melalui pembelajaran aktif tipe card sort dapat mengembangkan kreativitas siswa dalam menyelesaikan soal PPKn mencapai 75%. Dengan indikator penilaian sebagai berikut: 1) mampu mengerjakan tugas yang tela diberikan pada pertemuan sebelumnya, 2) siswa mampu menjawab soa atau jawaban di atas 75%, 3) siswa mampu menempatkan soal atau jawaban di atas 75%. Penelitian ini dilakukan di SDI Onekore 3 pada siswa kelas VB dengan jumlah 39 orang. Pengumpulan data dilakukan dengan observasi, wawancara, dokumentasi dan catatan lapangan. Analisis data dalam penelitian ini dilakukan secara deskriptif kualitatif. Hal ini dapat dilihat pada akhir siklus II, dimana kemampuan siswa mengerjakan tugas 86,49 % dari 28,21 % Kemampuan siswa menjawab soal PPKn dengan benar 89,19 % dari 69,23 %. Kemampuan siswa menempatkan kartu soal atau jawaban berdasarkan kategori mencapai 97,30 % dari 58,97 %. Sikap siswa terhadap pembelajaran aktif tipe card sort secara umum sikapnya positif. Hal ini dapat dilihat pada dua siklus pernyataan sikap pada siklus I 92,31 % dan siklus II 98,20 %. Kesimpulan dari penelitian ini bahwa dengan penggunaan pendekatan pembelajaran aktif tipe card sort dapat meningkatkan kreativitas siswa dalam menyelesaikan soal PPKn di atas 75%  pada materi Kebebesan Berorganisasi. Dengan demikian peningkatan kreativitas ini akan berdampak pada peningkatan hasil belajar siswa.
MENGGALI KEARIFAN LOKAL DALAM PEMBELAJARAN DI SEKOLAH DASAR: PENDEKATAN LITERATUR ETNOPEDAGOGI UNTUK MENINGKATKAN KUALITAS PENDIDIKAN
Authors: Wardhani Dyah Ayu Pramoda , Yusuf Nanang Andri , Rahmadhani Risa , Anggraini Novia
Published: December 2024

Peningkatan mutu pendidikan di Indonesia khususnya pada tingkat dasar (dasar) menjadi tujuan utama. Salah satu cara yang dianggap sebagai praktik yang baik adalah dengan memasukkan kearifan lokal ke dalam program untuk meningkatkan pengalaman siswa dan meningkatkan hubungan mereka dengan budaya lokal. Penelitian ini menggunakan metode tinjauan pustaka untuk mengetahui penerapan literatur etnografi dalam menggali kearifan lokal di sekolah dasar. Hasilnya menunjukkan bahwa metode ini efektif dalam meningkatkan pemahaman siswa terhadap budaya lokal dan memperkuat karakternya. Mengintegrasikan kearifan lokal juga mempererat hubungan antara sekolah dan masyarakat serta membantu pengembangan karakter siswa. Namun diperlukan penelitian dan partisipasi berbagai pihak untuk memperbaiki sistem ini dan meningkatkan kualitas pendidikan dasar di Indonesia.
ANALISIS KETERAMPILAN MENULIS PERMULAAN MENGGUNAKAN MEDIA GAMBAR PADA SISWA KELAS 1 SEKOLAH DASAR
Authors: Dari Resti Putri Ulan
Published: December 2024

Penelitian ini bertujuan untuk mendeskripsikan keterampilan menulis permulaan menggunakan media gambar pada siswa kelas 1 SDN 22 Singkawang. Metode yang digunakan peneliti ini adalah metode deskripsi kualitatif. Subjek penelitian ini adalah siswa kelas 1 SDN 22 Singkawang yang terdiri dari 23 siswa. Instrument pengumpulan data dalam penelitian ini adalah menggunakan lembar tes, wawancara, dan dokumentasi. Dalam lembar soal menuliskan huruf, menuliskan kata, menuliskan kalimat sederhana, dan penggunaan tanda baca. Teknik analisis data menggunakan Teknik analisis soal Miles dan Huberman yang terdiri dari reduksi data, penyajian data, dan menyimpulkan data. Penelitian ini menunjukan data diperoleh dari keterampilan siswa dalam menulis permulaan menunjukan kriteria sangat baik ada 15 siswa dengan presentase 65,21%, kriteria baik 3 siswa dengan presentase 13,04%, kriteria cukup ada 3 siswa dengan prsentase 13,04% dan kriteria butuh bimbingan ada 2 siswa dengan prsentase 8,69%. Kesimpulan dari penelitian ini bahwa rata-rata siswa dalam menulis permulaan yaitu 81,34% dengan kategori baik.
STRUKTUR WOE JAWA (SUKU JAWA) DI DESA BEI WALI KECAMATAN BHAJAWA KABUPATEN NGADA NUSA TENGGARA TIMUR
Authors: Hoban Nong , Bhara Agustinus , Bego Karolus Charlaes
Published: December 2024

Tujuan penulisan adalah mengetahui struktur woe jawa (suku Jawa) di desa Bei Wali Kecamatan Bhajawa Kabupaten Ngadha. Methode penelitian yang digunakan adalah penelitian kualitatif. Teknik pengumpulan data adalah wawancara, observasi, dan dokumentasi, Teknik analisis data sebagai berikut: reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: woe jawa  adalah salah satu organisasi sosial geneologis, sama halnya dengan woe-woe lain yang ada pada suku bangsa Ngada, khususnya masyarakat penganut budaya  ngadhu bhaga.  Woe jawa sebagai sebuah organisasi, maka woe jawa memiliki struktur yang menjadi pedoman untuk mengatur kehidupan sosial dan ekonomi dalam persekutuannya.
PERIOPERATIVE MANAGEMENT OF INDIVIDUALS WITH ANTICOAGULANT AND ANTIPLATELET THERAPY
Authors: Bryam Esteban Coello García  , Pilar Alejandra Parreño Castillo  , Angélica Karina Guamán Lema  , Christian Paul Flores Tapia  , Celina Soledad Villavicencio Delgado  , María de Lourdes Sánchez Tuapante
Published: December 2024

Introduction: The increased use of anticoagulant therapy and antiplatelet therapy requires careful management, especially in patients requiring surgery. These treatments include oral and parenteral options which must be balanced with the risk of bleeding and thrombosis. They are fundamental in both prevention and treatment of thromboembolic events.
Objective: to present clear and precise recommendations for the perioperative management of TAC and antiplatelet agents.
Methodology: a total of 30 articles were analyzed in this review, including review and original articles, as well as clinical cases, of which 17 bibliographies were used because the other articles were not relevant for this study. The sources of information were PubMed, Google Scholar and Cochrane; the terms used to search for information in Spanish, Portuguese and English were: oral anticoagulants, antiplatelet agents, TACO, antithrombolytic therapy, new oral anticoagulants.
Results: the study showed that restarting low molecular weight heparins in therapeutic doses before 24 hours post-surgery increases the risk of bleeding, so it is recommended to use prophylactic doses. Furthermore, it emphasizes the importance of adjusting anticoagulant therapy according to the thromboembolic and hemorrhagic risk of each patient.
Conclusions: anticoagulant and antiplatelet drugs are essential to prevent thromboembolic events in pathologies such as acute coronary syndrome and cerebrovascular diseases. Their perioperative management should consider the thrombotic and hemorrhagic risk, as well as the type of surgery and drug. Heparins, vitamin K antagonists and new oral anticoagulants require adjustments in doses and withdrawal times to prevent complications. In addition, reversal of their anticoagulant effect in emergencies is key, with advances in agents such as idarucizumab and andexanet alfa for greater effectiveness in critical situations.
KEY WORDS: TACO, anticoagulants, antiplatelet agents.
Psychosocial Aspects Of Rehabilitation Of The National Guard Of Ukraine Soldiers Injured In Combat
Authors: Hrynzovskyi Anatolii , Bielai Serhii V. , Vasischev Vladimir S. , Pasichnik Vladimir I. , Kernickyi Aleksandr M. , Tovma Mykola I.
Published: December 2024

The aim: on the basis of multidisciplinary approaches, to identify the main problems and analyse the psychosocial aspects of the rehabilitation of servicemen of the National Guard of Ukraine and to develop a technology for the formation of psychological skills for psychosocial recovery in order to use it in the practice of psychosocial assistance to servicemen of the National Guard of Ukraine who were injured during the russian-ukrainian war.
Materials and methods: The following research methods were used to study the psychosocial aspects of the rehabilitation of soldiers of the National Guard of Ukraine who were wounded during hostilities: comparative, statistical, content analysis, analysis of activity products, synthesis, specification.
Conclusions: on the basis of multidisciplinary approaches, the main problems were identified and the psychosocial aspects of the rehabilitation of soldiers of the National Guard of Ukraine were analysed, and the technology of forming psychological skills for psychosocial recovery was proposed with the aim of using it in the practice of psychosocial assistance to soldiers of the National Guard of Ukraine who were injured during the russian-ukrainian conflict war.
Correction of dysmenorrhea in teenage girls with autonomic dysfunction syndrome
Authors: Rusyn lyudmyla , Pulyk Oleksandr , Hyryavets Myroslava
Published: December 2024

Aim: The aim of our study was detection and correction of dysmenorrhea in teenage girls with autonomic dysfunction syndrome.
Materials and Methods: The research group consisted of 37 teenage girls, aged 12-16 years, who were undergoing rehabilitation treatment with signs of
dysmenorrhea and vegetative dysfunction syndrome. The study lasted for 2 years (2020-2021). A study of the variability of the heart rate at rest and under
the conditions of an orthostatic test was carried out using the “Cardiolab” complex by the method of spectral analysis.
Results: Analyzing the initial state of the autonomic nervous system in girls with menstrual cycle disorders, the primary predominance of the sympathetic
nervous system in 33.3% of girls was revealed. Before treatment, autonomic reactivity was characterized by a hypersympathetic type in 44.4% of girls, by an
asympathetic type in 22.3% of children. Spectral analysis at the beginning of treatment showed that high frequencies (HF) prevail in most girls (66.0%), which
indicates an increased influence of the parasympathetic part of the autonomic nervous system, and 18.5% of girls have a balanced state of the autonomic
nervous system. Predominance in the spectrum of LF and VLF components was found in 15.5%, which indicates the predominance of central humoral-metabolic
ergotropic effects on heart rate variability. After the course of treatment an improvement in the condition of teenage girls was observed. Menstruation
became less painful or painless at all, the duration and frequency of menstruation (from 1 to 3 days, on average 1.8±0.1) and blood loss decreased. The girls
felt better, did not complain of dizziness and headache.
Conclusions: According to the results of the study, it was found that the proposed course of treatment for teenage girls with a menstrual cycle disorder with
signs of autonomic dysfunction contributed to the normalization of the cycle, improvement of the general condition of the girls.
Recognition of Kosovo: limitations of the GDR model
Authors: Skrynka Dmytro
Published: December 2024

The Russian full-scale invasion of Ukraine in 2022 led to a reassessment of the system of international relations by various international actors, from China to the European Union (EU). For the EU, the reassessment meant, inter alia, the increase in priority of the EU integration of the Western Balkan states. One of the prerequisites for the complete EU integration of the Western Balkans is the normalization of the relations between Serbia and Kosovo.
The importance of such normalization is reminiscent of the significance of the establishment of relations between FRG and GDR, in particular the 1972 Basic Treaty for the security and stability in Europe at the time of the détente (the GDR model). Given the pragmatic but reserved approach used in the 1972 Treaty, it was not surprising that the Treaty provisions were used in drafting the Agreement on the path to normalization between Kosovo and Serbia. However, there are numerous crucial differences between the two situations, and a full understanding of such differences is critical for the implementation of the GDR model in the normalization of Serbia-Kosovo relations. In the article, some of the political, economic, religious, and legal factors differentiating the FRG-GDR situation from the Serbia-Kosovo situation are compared and analysed. Thus, the limitations of the GDR model will be determined as used for the Serbia-Kosovo normalization. Such determination will be useful in designing the future steps in the Serbia-Kosovo normalization.
Enhancing Writing Accuracy and Complexity through AI-Assisted Tools among Moroccan EFL University Learners
Authors: Azennoud Abdessatar
Published: December 2024

The present study investigates the effectiveness of the use of AI-powered tools, such as ChatGPT and Grammarly, in improving writing accuracy and complexity among Moroccan University English as a Foreign Language (EFL) learners. Since education in the 21st century has undergone radical and rapid changing landscape due to the advancement and integration of Artificial Intelligence (AI), there is a pressing need in examining its potential impact on language learning, particularly in enhancing the complexity and accuracy of the writing skill. Numerous studies were carried out on the impact of AI-powered tools on writing in general, but a few of them were conducted on the impact of these tools on particular writing subskills, like accuracy and complexity; hence this piece of research attempts to fill this gap. The study employs a quantitative design, administering a Likert-scale questionnaire to Moroccan University EFL learners to assess how their use of AI-powered tools influences writing accuracy and complexity. The findings revealed a positive impact on writing accuracy and complexity among Moroccan EFL learners, resulting in the production of complex syntactic structures and error-free constructions. This improvement primarily stems from the AI-powered tools' ability to provide personalized feedback and foster self-directed learning. Interestingly, the study also showed a strong positive correlation between accuracy and complexity, indicating that improvement in one aspect leads to improvement in the other. Such results serve as a trigger for decision-makers, including curriculum designers, to properly integrate AI in education for reinforcing writing instruction and support EFL learners in their language learning development.
Manejo De Frutos Y Semillas, Producción De Plantines Y Establecimiento A Campo De Especies Nativas: Especie: Plinia Rivularis (Cambess.) Rotman Mirtaceae (Ivaporiti)
Authors:   Universidad Nacional de Misiones. Facultad de Ciencias Forestales. Laboratorio de Semillas, Rodríguez Gabriela ,   Argentina., González Cecilia ,   Universidad Nacional de Misiones. Facultad de Ciencias Forestales. Laboratorio de Semillas; Argentina., Eibl Beatriz I. ,   Universidad Nacional de Misiones. Facultad de Ciencias Forestales. Laboratorio de Semillas; Argentina.
Published: December 2024

(ANTON y ZULOAGA 2018; GONZALEZ, 2011).
El ivaporiti es una especie nativa que se distribuye en Argentina, Paraguay, Uruguay y Brasil. En la Argentina está presente en Misiones, Corrientes y Entre Ríos.
Hojas: simples, pecioladas, filotaxis opuesta, glabras.
Flor y fruto: las flores son de color blanco, con numerosos estambres, perfumadas, melíferas, dispuestas en racimos. Los frutos son comestibles, globosos de 1-1,5 cm de diámetro, color rojo-negro brillantes cuando están maduros, lisos, y de pulpa suculenta color crema (imagen 1).
Semillas: 1 o 2 semillas por fruto (imagen 2).
Renascimento Verde: uma solução para a restauração de florestas ripárias através do banco de sementes
Authors: Bao Francielli , Nunes da Cunha Cátia , Benedito de Souza Evaldo , Rodrigues da Silva Nuno , Ribeiro Silva Suelma
Published: December 2024

A restauração ecológica é essencial para manter a biodiversidade frente às mudanças globais do clima. O banco de sementes é a principal fonte de manutenção da variabilidade genética de populações e comunidades. Uma avaliação precisa das sementes contidas no solo após um evento extremo sazonal em áreas úmidas traz respostas quanto ao potencial de regeneração natural. Dessaforma, objetivamos investigar o uso dos bancos de sementes do solo como uma ferramenta de avaliação da degradação de florestas ripárias e sua capacidade de regeneração após eventos de fogo e inundações. O banco de sementes foi coletado em dois períodos: pós fogo e pós inundação; e o solo foi avaliado por meio da emergência de plântulas e por contagem direta de sementes. As espécies foram classificadas quanto ao hábito, forma de vida, dispersão, tipo de propagação e ciclo de vida. Registramos como resultados: foi baixo o número de sementes arbóreas e arbustivas; as ervas e gramíneas terrestres e perenes apresentam maiores valores de CWM; e espécies com rebrota basal se destacam das demais. A Cecropia pachystachya é a principal espécie representante dentro do banco de sementes (maior abundância), sendo a zoocoria o principal meio de dispersão, seguido de hidrocoria e autocoria. Pode-se observar que o banco de sementes tem uma diversidade de espécies que não utilizam as sementes como principal meio de regeneração desta floresta ripária. As espécies presentes estão condicionadas a algum tipo de propagação vegetativa e podem se manter no ambiente via rebrote.
Revitalizing Islamic Cultural History: The Impact and Implementation of Online Learning
Authors: Muntohar Muntohar , Wasike Nabiswa Martin
Published: December 2024

Purpose of the study: This research aims to provide an overview of the process and results of implementing online learning in Islamic cultural history subjects at State Islamic High School 2 Cilacap.
Methodology: The type of research used by researchers in this research is field techniques using a qualitative descriptive approach.
Main Findings: The results of this research include the objectives of online learning for the history of Islamic culture at State Islamic High School 2 Cilacap, which consists of e-learning based learning to make learning materials accessible to other people. The benefits of online learning are to overcome space and time limitations between teachers and students. The advantages and obstacles of online learning.
Novelty/Originality of this study This research provides a unique contribution by presenting specific information about the implementation of online learning in the Madrasah Aliyah environment with a focus on the history of Islamic culture. This can be a reference and source of inspiration for further research in a similar context.
Pathophysiological Mechanisms and Therapeutic Drug Targets for Complex Regional Pain Syndrome – Type I
Authors: Ragavendran Jegadeesan Vaigunda , Coderre Terence J
Published: December 2024

Reflex sympathetic dystrophy (RSD), also known as complex regional pain syndrome type I (CRPS-I), is a disabling neuropathic pain syndrome. It is characterized by regional disabling pain, increased sensitivity to tactile stimuli, swelling, vasomotor and sudomotor abnormalities, and impairment of motor function. The disorder usually develops after minor trauma (contusions, sprains, and fractures) or surgery. Pathophysiologically, there is evidence for functional changes within the central nervous system and for involvement of peripheral inflammatory processes, the signs of which are very much evident at the early stage of the disorder. The sympathetic nervous system plays a key role in maintaining pain and autonomic dysfunction in the affected extremity. Accordingly, in the chronic stages of the disease, patients present with a cold-affected extremity and atrophy of skin, muscles, and bones. Increased vasoconstriction, tissue hypoxia, and consequently metabolic tissue acidosis have all been demonstrated in the affected extremity. As for therapeutic drug targets, various modalities of drug action have been extensively studied, which include targeting regional inflammation, ion channels, spinal pain pathways, sympathetic nervous system and the NMDA receptor. Hence, the aim of the present article is to comprehensively review the multifarious pathophysiological mechanisms underlying pain in CRPS-I and the molecular drug targets that are studied to develop newer drug molecules for the effective treatment of this pain condition.
Design and Synthesis of 2-(5-ethyl-pyridine-2-yl) ethanol Analogs as Potential Microbial Agents
Authors: B. Patel Navin , R.Patel Hemant
Published: December 2024

A novel series of chalcones and pyrimidines is described. The structures of the synthesized compounds were assigned on the basis of elemental analysis, IR, 1H NMR and 13C NMR spectral data. All the products were screened against different strains of bacteria and fungi. Most of these compounds showed better inhibitory activity in comparison to the standard drugs.
Synthesis and Antitubercular Activity of 5-benzyl-3-phenyl dihydroisoxazoles
Authors: Bisht Surendra Singh , Ajay Arya , Sinha Sudhir Kumar , Chaturvedi Vinita , Tripathi Rama P
Published: December 2024

Hetero Diels-Alder reaction of aromatic aldoximes with different alkenes resulted in highly substituted dihydroisoxazoles (1-12) in good yields. All the compounds were evaluated for antitubercular activity against Mycobacterium tuberculosis H37Ra and H37Rv. Compounds 2, 3, 6, and 10 exhibited antitubercular activity with minimum inhibitory concentration (MIC) ranging from 12.5 to 3.12 g/mL against the infectious strain M. tuberculosis H37Rv.
The Stacking Ability of Daunomycin with Base Pairs of DNA: A Theoretical ab Initio (HF) and MP2 Studies
Authors: Bezbaruah Bipul
Published: December 2024

The description of the intercalative mode of DNA binding of daunomycin is important to understand the sequence selectivity of this drug. Indirectly, DNA sequence specific intercalation can be assessed from the stacking stabilization of chromophore with AT and GC base pairs. For both the stacked complexes of chromophore with AT and GC base pairs, the interaction of certain molecular parts are essentially related to the base pair specificity of this drug. The observed variation in the stacking interactions of molecular parts of chromophore and base pairs have been determined from the interactions of rings A,B and C of chromophore with base pairs. Unlike the other aromatic rings, the ring D is not favourable for stacking interaction. The differences in the structures and interaction energies are used to rationalize the regions of stacking stabilization as well as repulsive interaction due to steric hindrance for certain stacked positions of chromophore. The favorable interaction is found only within the non steric orientations of chromophore in the stacked structures. The interaction energies of chromophore and AT are different from that of GC, and also there observed differences between the interaction energies of drug and base pairs for major and minor groove orientations.
Synthesis of 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole amino acid Derivatives and Anti-DNA Damaging Activity
Authors: S.R Ranganatha , K Vinaya , S. Chandrappa , C. S. Ananda Kumar , S. B Benaka Prasad , D.S Prasanna , K.S. Rangappa
Published: December 2024

Series of novel 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole L-amino acid derivatives 5(a-f) were synthesized by varying substitution at N-position of the 6-fluoro-3-(4-piperidinyl)-1,2-benzisoxazole. All the compounds 5(a-f) were characterized by 1H-NMR, IR and LC/MS spectroscopy. The compounds were tested for anti-DNA damaging property by using biophysical techniques such as agarose gel, thermal melting temperature (Tm) and ethidium bromide binding to DNA by using fluorescence spectrophotometer. The results revealed that 5c, 5b and 5d showed high activity. These observations can be related to the presence of the lysine, tryptophan and proline amino acid residues with basic amine, aromatic and heterocyclic groups respectively.
Synthesis, In-vitro Evaluation and Computational Studies of Novel Isatinyl Derivatives for their Activity against HIV-TB Co-Infection
Authors: Banerjee Debjani , Perumal Yogeweswari , Thomas Anisha , Dharmarajan Sriram
Published: December 2024

The depleting T-lymphocyte count during acquired immunodeficiency syndrome (AIDS) predisposes the patients to many opportunistic infections, primary of which is Tuberculosis (TB). HIV-TB coinfection has acquired pandemic proportion especially in developing countries. Two series of novel N,N-diallyl/diphenyl-2-(5-substituted-1-(arylmethyl/alkylmethyl)-2-oxoindolin-3-ylidene)hydrazinecarbothioamide were synthesized and evaluated for their anti-retroviral capability on MT-4 cell lines as well as for their potential to repress TB in both logarithmic and dormant phases. They were also subjected to evaluation for their ability to repress Mycobacterium tuberculosis (MTB) Isocitrate lyase (ICL), an enzyme which is essential for the bacilli to survive in starved cultures. Amidst the entire array of compounds, N,N-diallyl-2-(1-((diethylamino)methyl)-5-methyl-2-oxoindolin-3-ylidene)hydrazinecarbothioamide (A12) demonstrated excellent activity against the growth of HIV-1 cell in vitro with EC50 value of 0.30 µM; and also had the best ICL inhibitory profile with 40.45% inhibition.
Synthesis and Biological Activities of N’-[4-(substituted benzylideneamino)-3- (2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazides
Authors: Hunas hala Rajesh , Ronad Pradeepkumar , Maddi Veeresh , Darbhamulla Satyanarayana , Kamdod Mohammad
Published: December 2024

N'-[4-(substituted benzylideneamino)-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl)] isonicotinyl hydrazide derivatives have been synthesized by the reaction between N′ -[4-amino-3-(2′,4′-dichlorophenoxymethyl)-1,2,4-triazol-5yl] isonicotinyl hydrazide and various aromatic aldehydes in presence catalytic amount of hydrochloric acid in alcohol. All these compounds were screened for antibacterial, antifungal and antitubercular activity. The compounds 3b and 3j exhibited more potent antifungal activity against A. niger, and A. fumigatus at MIC of 0.25 µg/mL.
Synthesis and in vitro Biological Activity of Organic Charge-transfer Complexes of lansoprazole, fluconazole, gabapentin and gabalactum with Chloranilic and Picric Acids
Authors: Mallesha Lingappa , N. Mohana Kikkeri
Published: December 2024

Novel Charge-transfer (CT) complexes were synthesized in order to determine their antimicrobial and antioxidant activity relationships to improve the efficacy. The purity of the synthesized complexes was judged by their elemental analyses, and their chemical structures were confirmed by UV-visible, FT-IR and 1H NMR spectral studies. Among the synthesized compounds, 2a and 2b showed good antimicrobial activity. Compound 1a showed moderate antioxidant activity compared to standard drug by diphenylpicrylhydrazyl (DPPH) assay method.
Discovery of Isatinimino Derivatives as New Leads for Neuropathic Pain Treatment: An Isomeric Modification Approach
Authors: Semwal Arvind , Yogeeswari Perumal , Ragavendran Jegadeesan Vaigunda , Dharmarajan Sriram , Stables James
Published: December 2024

Isatin, an endogenous compound identified in humans possesses a wide range of biological properties. Among them the most significant being anxiogenic, anticonvulsant and analgesic activities. Neuropathic pain arises due to damage or permanent alteration of the peripheral or central nervous system. The major inhibitory neurotransmitter of the central nervous system (CNS), γ-aminobutyric acid (GABA) has been implicated in the etiology and pharmacotherapy of different neurological and psychiatric disorders including pain and epileptic conditions. Hence, the present study is aimed at design and synthesis of newer isatinimino GABA derivatives useful in the treatment of neurological disorders like neuropathic pain and epilepsy. Various isatinimino GABA amides were synthesized and screened for peripheral analgesic, antiallodynic, antihyperalgesic and anticonvulsant activities. The structures of the synthesized compounds were confirmed by the use of their spectral data besides elemental analysis. The synthesized derivatives of the inhibitory neurotransmitter GABA produced anticonvulsant and antinociceptive actions in the acetic acid induced writhing test and in two peripheral nerve injury models of neuropathic pain.
Conventional as well as Microwave Assisted Synthesis Characterization and Antimicrobial Studies of Some New Derivatives of -5-[2'-Marcapto-1-Methylene)-(1', 3’, 4’-Thiadiazoles)] - 1, 2, 3-Benzotriazoles
Authors: Sen J.P. , Shukla D.K. , Jain A
Published: December 2024

As a part of systematic investigation of conventional as well as microwave assisted synthesis and antimicrobial activity, of several new 5-[(2'-N-sub.arylidene hydrazinothioacetyl)-1-(methylene)-1',3',4'-thiadia-zoles)]-1,2,3-benzotriazoles 3a and 5-[(2'-sub.aryl-3'"-chloro-2'"-oxo-azetidine)-1"-(iminothioacetyl)-1-(methylene-1',3',4'-thiadiazole)]-1,2,3-benzotriazole1 as the starting material. All the synthesized products were evaluated for their antibacterial activity against Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae and Bacillus substilis and antifungal activity against Aspergillus Niger, Aspergillus flavus, Fusarium oxisporum and Trichoderma viride. The structures of all the synthesized compounds have been determined by spectral and chemical methods.