bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspektiven der Landesinstitute zur Steuerung digitalisierungsbezogener Professionalisierung von Schulleitungen zwischen Erwartung und Unterstützung: „Aber wenn er nicht ‚Piep‘ sagt, dann kommen wir nicht.“
Authors: Kruse Christoph , Grigoleit Ella , Tulowitzki Pierre
Published: November 2022

In diesem Artikel der Zeitschrift Gruppe. Interaktion. Organisation. werden auf Basis von Daten aus einer Interviewstudie die Perspektiven von Landesinstituten für Schulen (LiS) auf die Schnittstelle zur Schulleitung im Rahmen digitalisierungsbezogener Schulentwicklung analysiert. Die LiS verantworten in diesem Kontext bedeutsame Professionalisierungsmaßnahmen für Schulleitungen. In der Analyseperspektive der Educational Governance werden die LiS bzgl. der Schnittstelle in einen doppelten Fokus genommen: Zum einen stellt sich die Herausforderung einer gelingenden Passung von Qualifizierungsmaßnahmen an der Schnittstelle von LiS und Schulleitung (sowohl inhaltlich als auch organisatorisch), sodass schulische Führungskräfte in ihrer digitalisierungsbezogenen Kompetenzentwicklung effektiv unterstützt werden können. Zum anderen kann diese Schnittstelle mit Fokus auf die Steuerung und Implementation gelingender digitalisierungsbezogener Schulentwicklung innerhalb des Bildungssystems analysiert werden. Das Ziel der Studie liegt darin, Relevanzsetzungen (im Sinne von Handlungslogiken) der LiS in der Gestaltung der Professionalisierungsangebote zu identifizieren und auf die Herstellung von Passung an der Schnittstelle (im Sinne gelingender Handlungskoordination) zu diskutieren. Es zeigt sich, dass die Handlungslogik der LiS u. a. von Steuerungsimpulsen des übergeordneten Ministeriums, aber maßgeblich auch von normativen Erwartungen sowie Anpassungsstrategien an die (wahrgenommenen) Handlungslogiken der Schulleitungen beeinflusst ist. Für die Steuerung und Handlungskoordination kommt insofern nicht nur (unilateral) den LiS, sondern (wechselseitig) auch der Schulleitung eine zentrale Bedeutung für die Gestaltung und potenzielle Wirkung der digitalisierungsbezogenen Professionalisierungsangebote zu. Hieran anschließende Probleme, Herausforderungen und Implikationen für die Forschung und (Steuerung der) Praxis werden diskutiert.
Assessing the applicability of cerebrospinal fluid collected from the spinal cord for the determination of ethyl alcohol in post-mortem toxicology
Authors: Wachholz Paulina , Skowronek Rafał , Pawlas Natalia
Published: November 2022

This paper presents the results of a study on the applicability of cerebrospinal fluid (CSF) collected from the spinal canal in the post-mortem determination of ethyl alcohol. The present study reviewed data of autopsy cases (n = 45), in which ethyl alcohol was detected in CSF using gas chromatography with a flame ionization detector (HS-GC-FID), to investigate ethyl alcohol concentrations in CSF, compared with blood. As a result of statistical analysis of the obtained data, a high positive correlation was found between blood ethanol concentration and cerebrospinal fluid collected from the spinal canal ethanol concentration. The Pearson correlation coefficient was statistically highly significant (p < 0.001) (r = 0.9503). The data obtained allowed us to conclude that cerebrospinal fluid collected from the spinal canal can be collected during an autopsy as an alternative biological specimen to assess the ethanol content. Cerebrospinal fluid collected from the spinal canal can corroborate and lend credibility to the results obtained for blood and, in special cases, when blood is drawn from putrefied bodies and may even be a superior specimen to blood for assessing ethyl alcohol intoxication status.
Dimensionen und konzeptuelle Merkmale des Community Health Nursing
Authors: Scheydt Stefan , Hegedüs Anna
Published: November 2022

Hintergrund

Die Ausbildung und Etablierung von sog. Community Health Nurses wird seit einigen Jahren postuliert und im Rahmen jüngster Modell- und Forschungsprojekte vorangetrieben. Es fehlt jedoch an einer klaren konzeptuellen Abgrenzung und Klärung der mit dem Konzept des Community Health Nursing (CHN) im Zusammenhang stehenden Dimensionen und Merkmale.

Ziel

Inhaltliche Differenzierung der Dimensionen von CHN und Explikation der damit in Verbindung stehenden konzeptuellen Merkmale und Inhalte.

Methode

Literatursynthese auf Grundlage einer unsystematisch durchgeführten Literaturrecherche in den elektronischen Datenbanken PubMed/Medline, CINAHL sowie Google und Google-Scholar mit anschließender narrativer Zusammenfassung und Strukturierung in Anlehnung an die qualitative Inhaltsanalyse nach Mayring.

Ergebnisse

Es konnten die CHN-Dimensionen „Public/Community Health Nursing“ (P/CHN) sowie „Community-based Nursing“ (CBN) hinsichtlich (a) Begrifflichkeit und Definitionen, (b) Ebenen und Fokus der Praxis sowie (c) Arbeitsfelder und Rollenprofile expliziert und differenziert werden.

Schlussfolgerung

Es ist eine weitere konzeptuelle Klärung und entsprechende Konsentierung der definierenden Merkmale der unterschiedlichen Dimensionen des CHN notwendig, um CHN sowohl auf grundlegendem als auch auf erweitertem Niveau langfristig für den deutschsprachigen Raum etablieren zu können.
Culture of integrity – institutional response to integrity during COVID19
Authors: Khan Zeenath Reza , Priya Joice , Tuffnell Christopher
Published: November 2022

COVID19 forced most education institutions to move their education provisions to digital platforms almost overnight to ensure continued learning for students. Variable factors relating to educational technologies, ease of use, accessibility and funding meant the process was more challenging for some than others. However even the most agile and well-prepared educational institutions faced a hurdle during remote learning when it came to integrity in assessing students online.

This article tracks the efforts by one western university in a Middle Eastern country, tracing back the systemic changes, evolution of policies and procedures that culminated into a campus-wide response that helped redesign assessments, increased awareness among faculty towards recognising and reporting cases, and the implementation of integrity pledges. It is believed this article presents a well-rounded case study as a good practice guide for other tertiary institutions on the importance of building a culture of integrity prior to any crisis, that can help whether such situations need to arrive in the future.
Comparing autoencoder-based approaches for anomaly detection in highway driving scenario images
Authors: Mosin Vasilii , Staron Miroslaw , Tarakanov Yury , Durisic Darko
Published: November 2022

Autoencoder-based anomaly detection approaches can be used for precluding scope compliance failures of the automotive perception. However, the applicability of these approaches for the automotive domain should be thoroughly investigated. We study the capability of two autoencoder-based approaches using reconstruction errors and bottleneck-values for detecting semantic anomalies in automotive images. As a use-case, we consider a specific highway driving scenario identifying if there are any vehicles in the field of view of a front-looking camera. We conduct a series of experiments with two simulated driving scenario datasets and measure anomaly detection performance for different cases. We systematically test different autoencoders and training parameters, as well as the influence of image colors. We show that the autoencoder-based approaches demonstrate promising results for detecting semantic anomalies in highway driving scenario images in some cases. However, we also observe the variability of anomaly detection performance between different experiments. The autoencoder-based approaches are capable of detecting semantic anomalies in highway driving scenario images to some extent. However, further research with other use-cases and real datasets is needed before they can be safely applied in the automotive domain.
Land use impacts of implementing a bus rapid transit system: case of Beirut southern corridor
Authors: Al-Shaar Walid , Adjizian-Gérard Jocelyne , Bonin Olivier , Nehme Nabil
Published: November 2022

This study investigates and forecasts the effects of implementing a newly proposed Bus Rapid Transit (BRT) system in Lebanon on the urban land use evolution between the years 2019 and 2049. It contributes to the emerging scientific literature by proposing a technique intended to identify the potential urban land use impacts of BRT. The identification of these impacts as part of the feasibility study for the BRT is considered important for policymakers, local officials, and urban planners. The impacts are identified by conducting the Analytical Hierarchy Process, based on data collected via survey and interviews with real estate experts. The outcomes show that implementing a BRT service complemented with bus feeder services will: (i) reshape the urban fabric, in proximity to BRT routes and particularly around the stations, by triggering the Transit-Oriented Development and increasing the attractivity of urban development by 6 to 9% according to the distance from BRT route; and (ii) increase the attractivity of urban development projects by 11% in areas distant from the highway if these areas are characterized by high coverage of bus feeder services, low possibility of an increase in estate prices, and medium to high public acceptance of the proposed BRT.
Understanding Stockhausen
Authors: Maconie Robin
Published: November 2022

This collection of essays addresses technical developments in telecommunications and sound recording that have guided the direction of musical aesthetics in the post-1950 era. Such information is readily available online but may appear counterintuitive to many who find its priorities difficult to grasp from a musical perspective. The author hopes to draw attention to the place of ideas of communication and flight in western tradition. This Element begins with Varèse and his 'noble noise', traverses the arrival of Information Theory and its influence, examples of early computer music, and ends with a defence of the sublime logic of Stockhausen's singing helicopters and tornados.
Greek identity and education in the seventeenth century: Theophilos Korydalleus’ political movement in the Orthodox East
Authors: Tsiotras Vasileios , Syros Vasileios
Published: November 2022

At the beginning of the seventeenth century the Athenian philosopher Theophilos Korydalleus launched a political programme intended to reinvigorate Hellenic culture and education in South-Eastern Europe as a core element of Greek Orthodox identity. Korydalleus’ ideas on political intervention in the educational affairs of the Orthodox Greeks are recorded in one of his public speeches as well as in his private letters. In these texts it is possible to trace the emergence of a group of loyalists and disciples, who worked together in a political movement: a ‘party of friends’. This article presents and discusses sources which have been overlooked or have received little scholarly attention. It identifies the characteristics and the ideological underpinnings of this movement from a political, religious, and educational perspective and analyses Korydalleus’ views on contemporary political developments.
Strong Belief is Ordinary
Authors: Clarke Roger
Published: November 2022

In an influential recent paper, Hawthorne, Rothschild, and Spectre (“HRS”) argue that belief is weak. More precisely: they argue that the referent of believe in ordinary language is much weaker than epistemologists usually suppose; that one needs very little evidence to be entitled to believe a proposition in this sense; and that the referent of believe in ordinary language just is the ordinary concept of belief. I argue here to the contrary. HRS identify two alleged tests of weakness – the neg-raising and weak upper bounds tests, as I call them – which they claim believe and think pass. But I identify several other expressions in ordinary English for attributing belief, all of which fail both tests. Therefore, even if HRS are correct that believe and think refer to a weak attitude, it does not follow that the ordinary concept of belief is weak. I conclude by raising some problems for the accounts of belief as guessing, building on HRS's arguments, due to Kevin Dorst, Matt Mandelkern, and Ben Holguín.
A Magnum Opus - Discussed: Faith, Freedom, and Family: New Studies in Law and Religion. By John Witte, Jr. Edited by Norman Doe and Gary S. Hauk. Tübingen: Mohr Siebeck, 2021. Pp. 791. €99.00 (paper); €99.00 (digital). ISBN: 9783161608766.
Authors: Welker Michael
Published: November 2022

Over the first two decades of the twenty-first century, John Witte, Jr. has not only carefully documented but also creatively promoted in many ways three very important developments: (1) the almost revolutionary worldwide reawakening of cooperation in the fields of law and religion after the termination of their long, fruitful history of cooperation in the mid-1800s; (2) the efforts to strengthen a justice-oriented legal culture in democratic societies and the legal, academic, and political appreciation of human rights (also in disputes with human rights skeptics); and (3) the reconciliation of traditional values and new needs for freedom in the ethos and law of marriage and family.
SEMIAMPLENESS FOR CALABI–YAU SURFACES IN POSITIVE AND MIXED CHARACTERISTIC
Authors: BERNASCONI FABIO , STIGANT LIAM
Published: November 2022

In this note, we prove the semiampleness conjecture for Kawamata log terminal Calabi–Yau (CY) surface pairs over an excellent base ring. As applications, we deduce that generalized abundance and Serrano’s conjecture hold for surfaces. Finally, we study the semiampleness conjecture for CY threefolds over a mixed characteristic DVR.
IMMORTAL OR EVERLASTING? BOOK 3 OF THE COMMENTARY ON ARISTOTLE'S DE ANIMA ASCRIBED TO PHILOPONUS
Authors: Ge Tianqin
Published: November 2022

This article focusses on a hitherto underappreciated distinction between immortality and everlastingness in a Greek commentary of disputed authorship on Aristotle's De anima Book 3. This article argues that this distinction calls into question the attribution of the commentary to Philoponus.
Artificial Market Timing in Mutual Funds
Authors: Busse Jeffrey A. , Ding Jing , Jiang Lei , Tang Yuehua
Published: November 2022

We document statistically significant relations between mutual fund betas and past market returns driven by fund feedback trading. Against this backdrop, evidence of “artificial” market timing emerges when standard market timing regressions are estimated across periods that span time variation in fund systematic risk levels, as is typical. Artificial timing significantly explains the inverse relation between timing model estimates of market timing and stock selectivity. A fund’s feedback trading relates to its past performance and remains significant after accounting for trading on momentum. Fund flows suggest that investors value feedback trading, which helps hedge downside risk during bear markets.
Live and direct? Censorship and racialised public morality in grime and drill music
Authors: de Lacey Alex
Published: November 2022

This article addresses the linguistic policing of grime and UK drill music. Existing studies often focus on the immediacy of the penal system. This article will instead explore the extent to which institutional bodies uphold and maintain a programme of racialised censorship across radio broadcasts, seeking to understand how these value judgements impact upon creative practice. It presents an ethnographic study of three radio shows that aired on BBC 1Xtra, demonstrating through interviews and analysis how the broadcaster's censorship practice unfairly renders Black artists as dangerous with criminal associations. Lyrical assertions of musical skill are misread as direct threats, while evocations of the quotidian are seen to cause violence rather than reflect artists’ surroundings. Importantly, it will show how artists’ work and words are adversely discriminated against owing to a legacy of racialised public morality that imposes greater sanctions and restrictions on artistic output: radio personalities must strike a balance between presenting voyeuristic excitement about a genre, and the need to meet (racialised) editorial standards; producers assiduously monitor new slang to make sure that it is censored; and artists are encouraged to self-censor and alter their musical output, to protect themselves from unwanted ramifications.
Moments of the Hurwitz zeta function on the critical line
Authors: SAHAY ANURAG
Published: November 2022

We study the moments$M_k(T;\,\alpha) = \int_T^{2T} |\zeta(s,\alpha)|^{2k}\,dt$of the Hurwitz zeta function$\zeta(s,\alpha)$on the critical line,$s = 1/2 + it$with a rational shift$\alpha \in \mathbb{Q}$. We conjecture, in analogy with the Riemann zeta function, that$M_k(T;\,\alpha) \sim c_k(\alpha) T (\!\log T)^{k^2}$. Using heuristics from analytic number theory and random matrix theory, we conjecturally compute$c_k(\alpha)$. In the process, we investigate moments of products of DirichletL-functions on the critical line. We prove some of our conjectures for the cases$k = 1,2$.
Most numbers are not normal
Authors: AVENI ANDREA , LEONETTI PAOLO
Published: November 2022

We show, from a topological viewpoint, that most numbers are not normal in a strong sense. More precisely, the set of numbers
$x \in (0,1]$
with the following property is comeager: for all integers
$b\ge 2$
and
$k\ge 1$
, the sequence of vectors made by the frequencies of all possibile strings of length k in the b-adic representation of x has a maximal subset of accumulation points, and each of them is the limit of a subsequence with an index set of nonzero asymptotic density. This extends and provides a streamlined proof of the main result given by Olsen (2004) in this Journal. We provide analogues in the context of analytic P-ideals and regular matrices.
Global optimisation of the mean first passage time for narrow capture problems in elliptic domains
Authors: Gilbert Jason , Cheviakov Alexei
Published: November 2022

Narrow escape and narrow capture problems which describe the average times required to stop the motion of a randomly travelling particle within a domain have applications in various areas of science. While for general domains, it is known how the escape time decreases with the increase of the trap sizes, for some specific 2D and 3D domains, higher-order asymptotic formulas have been established, providing the dependence of the escape time on the sizes and locations of the traps. Such results allow the use of global optimisation to seek trap arrangements that minimise average escape times. In a recent paper (Iyaniwura (2021) SIAM Rev.63(3), 525–555), an explicit size- and trap location-dependent expansion of the average mean first passage time (MFPT) in a 2D elliptic domain was derived. The goal of this work is to systematically seek global minima of MFPT for
$1\leq N\leq 50$
traps in elliptic domains using global optimisation techniques and compare the corresponding putative optimal trap arrangements for different values of the domain eccentricity. Further, an asymptotic formula for the average MFPT in elliptic domains with N circular traps of arbitrary sizes is derived, and sample optimal configurations involving non-equal traps are computed.
Multilingualism and verbal short-term/working memory: Evidence from academics
Authors: Fyndanis Valantis , Cameron Sarah , Hansen Pernille Bonnevie , Norvik Monica I. , Simonsen Hanne Gram
Published: November 2022

To date, the evidence regarding the effect of bilingualism/multilingualism on short-term memory (STM) and working memory (WM) capacity is inconclusive. This study investigates whether multilingualism has a positive effect on the verbal STM and WM capacity of neurotypical middle-aged and older individuals. Eighty-two L1-Norwegian sequential bilingual/multilingual academics were tested with tasks measuring verbal STM/WM capacity. Degree of bilingualism/multilingualism for each participant was estimated based on a comprehensive questionnaire. Different measures of bilingualism/multilingualism were used. Data on potentially influencing non-linguistic factors were also collected. Correlation and regression analyses showed that multilingualism impacts both verbal STM and verbal WM. In particular, all analyses showed that number of known foreign languages was the strongest predictor of verbal STM and WM capacity. The results are discussed in light of recent studies on the impact of bilingualism on STM/WM and on recent proposals regarding the mechanism underlying so-called bilingual advantage.
Supporting the Barrister Profession: The Law Library at The Bar of Ireland
Authors: Byrne Nuala
Published: November 2022

This article by Nuala Byrne describes how the Library and Information Service of The Bar of Ireland, The Law Library, developed to support the profession of barrister from 2004 to the present day. It highlights key priorities addressed in the earlier years and how the service has developed since to deliver a modern, networked, knowledge-based library and information service, to barristers who are members of The Bar of Ireland.
An Analysis of the GDPR Compliance Issues Posed by New Emerging Technologies
Authors: Mone Varda , Sivakumar CLV
Published: November 2022

New emergent technologies, like cloud computing, blockchain, the ‘internet of things’, and artificial intelligence (AI), have received significant attention from research and industry. Public and private organisations benefit from these technologies, but the privacy of individuals is threatened. This research paper, by Varda Mone and CLV Sivakumar, analyses the existing data protection laws with respect to new emerging technologies like AI, big data, and algorithms. The purpose is first, to discuss and analyse the impact and emergence of modern concepts like big data, algorithms and artificial intelligence (AI), Cloud computing, and the ‘internet of things’, etc mainly in light of GDPR (General Data Protection Regulation) provisions. The article examines the challenges of GDPR compliance posed by the features of these technologies, both individually and collectively. Due to the unique features of these technologies, we are able to identify areas of compliance that needed attention. With regard to the compliance issues identified, we discuss possible solutions as well as raise new questions for further investigation. It is not an exhaustive assessment of these fields but an attempt is made to shed light on a few of them from a data protection perspective.
Virals, Memes, and the Lick's Circulation through Online Jazz Communities
Authors: JUDD HANNAH
Published: November 2022

In 2011, Alex Heitlinger, a senior at New England Conservatory, uploaded the video ‘The Lick’ to YouTube. The 1′34″ compilation excerpted a range of performances that each deployed the same seven-note ‘lick’. This article explores the digital dissemination of videos and memes that feature the Lick, suggesting its function as a mimetic device users can deploy to signal their belonging and individuality within a larger jazz community. The Lick, in its formulaic deployment within these ‘insider’ spaces, moves away from improvisation and becomes a calling card for performers and listeners alike to determine a legitimate participant, on and offline. The Lick's online proliferation becomes a gimmick through its repetition, pointing to its hyper-presence and complaints about the excessive posts of the Lick becoming recycled into over-repeated jokes. I argue the Lick serves as the basis for a study of humour and gimmickry in jazz identity formation.
SPY1 inhibits neuronal ferroptosis in amyotrophic lateral sclerosis by reducing lipid peroxidation through regulation of GCH1 and TFR1
Authors: Wang Di , Liang Weiwei , Huo Di , Wang Hongyong , Wang Ying , Cong Chaohua , Zhang Chunting , Yan Shi , Gao Ming , Su Xiaoli , Tan Xingli , Zhang Wenmo , Han Ling , Zhang Dongmei , Feng Honglin
Published: November 2022

Ferroptosis is an iron-dependent cell death with the accumulation of lipid peroxidation and dysfunction of antioxidant systems. As the critical regulator, glutathione peroxidase 4 (GPX4) has been demonstrated to be down-regulated in amyotrophic lateral sclerosis (ALS). However, the mechanism of ferroptosis in ALS remains unclear. In this research, bioinformatics analysis revealed a high correlation between ALS, ferroptosis, and Speedy/RINGO cell cycle regulator family member A (SPY1). Lipid peroxidation of ferroptosis in hSOD1G93A cells and mice was generated by TFR1-imported excess free iron, decreased GSH, mitochondrial membrane dysfunction, upregulated ALOX15, and inactivation of GCH1, GPX4. SPY1 is a “cyclin-like” protein that has been proved to enhance the viability of hSOD1G93A cells by inhibiting DNA damage. In our study, the decreased expression of SPY1 in ALS was resulted from unprecedented ubiquitination degradation mediated by MDM2 (a nuclear-localized E3 ubiquitin ligase). Further, SPY1 was identified as a novel ferroptosis suppressor via alleviating lipid peroxidation produced by dysregulated GCH1/BH4 axis (a resistance axis of ferroptosis) and transferrin receptor protein 1 (TFR1)-induced iron. Additionally, neuron-specific overexpression of SPY1 significantly delayed the occurrence and prolonged the survival in ALS transgenic mice through the above two pathways. These results suggest that SPY1 is a novel target for both ferroptosis and ALS.
Evidence for a robust sign-changing s-wave order parameter in monolayer films of superconducting Fe (Se,Te)/Bi2Te3
Authors: Chen Guannan , Aishwarya Anuva , Hirsbrunner Mark R. , Rodriguez Jorge Olivares , Jiao Lin , Dong Lianyang , Mason Nadya , Van Harlingen Dale , Harter John , Wilson Stephen D. , Hughes Taylor L. , Madhavan Vidya
Published: November 2022

The Fe-based superconductor Fe (Se,Te) combines non-trivial topology with unconventional superconductivity and may be an ideal platform to realize exotic states such as high-order topological corner modes and Majorana modes. Thin films of Fe (Se,Te) are particularly important for device fabrication and phase sensitive transport measurements. While bulk Fe (Se,Te) has been extensively studied, the nature of the superconducting order parameter in the monolayer limit has not yet been explored. In this work, we study monolayer films of Fe (Se,Te) on Bi2Te3 with scanning tunneling spectroscopy. Monolayer Fe (Se,Te)/Bi2Te3 heterostructures host a multigap superconducting state that strongly resembles the bulk. Analysis of the phase-referenced quasiparticle interference signal reveals a sign-changing s-wave order parameter similar to the bulk as well as a unique pattern of sign changes which have not been observed in the bulk. Our work establishes monolayer Fe (Se,Te)/Bi2Te3 as a robust multi-band unconventional superconductor and sets the stage for explorations of non-trivial topology in this highly-tunable system.
A three-photon head-mounted microscope for imaging all layers of visual cortex in freely moving mice
Authors: Klioutchnikov Alexandr , Wallace Damian J. , Sawinski Juergen , Voit Kay-Michael , Groemping Yvonne , Kerr Jason N. D.
Published: November 2022

Advances in head-mounted microscopes have enabled imaging of neuronal activity using genetic tools in freely moving mice but these microscopes are restricted to recording in minimally lit arenas and imaging upper cortical layers. Here we built a 2-g, three-photon excitation-based microscope, containing a z-drive that enabled access to all cortical layers while mice freely behaved in a fully lit environment. The microscope had on-board photon detectors, robust to environmental light, and the arena lighting was timed to the end of each line-scan, enabling functional imaging of activity from cortical layer 4 and layer 6 neurons expressing jGCaMP7f in mice roaming a fully lit or dark arena. By comparing the neuronal activity measured from populations in these layers we show that activity in cortical layer 4 and layer 6 is differentially modulated by lit and dark conditions during free exploration.
Cleaning of LTCC, PEN, and PCB Au electrodes towards reliable electrochemical measurements
Authors: Fakhr Mahan Hosseinzadeh , Beshchasna Natalia , Balakin Sascha , Carrasco Ivan Lopez , Heitbrink Alexander , Göhler Fabian , Rösch Niels , Opitz Joerg
Published: November 2022

Surface cleaning of the working electrode has a key role in improved electrochemical and physicochemical properties of the biosensors. Herein, chemical oxidation in piranha, chemical cleaning in potassium hydroxide-hydrogen peroxide, combined (electro-) chemical alkaline treatment, and potential cycling in sulfuric acid were applied to gold finish electrode surfaces deposited onto three different substrates; low temperature co-fired ceramics (LTCC), polyethylene naphthalate (PEN), and polyimide (PI), using three different deposition technologies; screen printing, inkjet printing, and electroplating (printed circuit board technology, PCB) accordingly. The effects of the (electro-) chemical treatments on the gold content and electrochemical responses of LTCC, PEN, and PCB applicable for aptamer-based sensors are discussed. In order to assess the gold surface and to compare the efficiency of the respective cleaning procedures; cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), X-ray photoelectron spectroscopy (XPS), and scanning electron microscopy (SEM) were employed. LTCC sensors electrochemically cycled in sulfuric acid resulted in the most gold content on the electrode surface, the lowest peak potential difference, and the highest charge transfer ability. While, for PEN, the highest elemental gold and the lowest peak-to-peak separation were achieved by a combined (electro-) chemical alkaline treatment. Gold content and electrochemical characteristics on the PCB surface with extremely thin gold layer could be slightly optimized with the chemical cleaning in KOH + H2O2. The proposed cleaning procedures might be generally applied to various kinds of Au electrodes fabricated with the same conditions comparable with those are introduced in this study.
Whole genome sequencing reveals epistasis effects within RET for Hirschsprung disease
Authors: Wang Yanbing , Mak Timothy Shin Heng , Dattani Saloni , Garcia-Barcelo Maria-Merce , Fu Alexander Xi , Yip Kevin Y. , Ngan Elly Sau-Wai , Tam Paul Kwang-Hang , Tang Clara Sze-Man , Sham Pak Chung
Published: November 2022

Common variants in RET and NRG1 have been associated with Hirschsprung disease (HSCR), a congenital disorder characterised by incomplete innervation of distal gut, in East Asian (EA) populations. However, the allelic effects so far identified do not fully explain its heritability, suggesting the presence of epistasis, where effect of one genetic variant differs depending on other (modifier) variants. Few instances of epistasis have been documented in complex diseases due to modelling complexity and data challenges. We proposed four epistasis models to comprehensively capture epistasis for HSCR between and within RET and NRG1 loci using whole genome sequencing (WGS) data in EA samples. 65 variants within the Topologically Associating Domain (TAD) of RET demonstrated significant epistasis with the lead enhancer variant (RET+3; rs2435357). These epistatic variants formed two linkage disequilibrium (LD) clusters represented by rs2506026 and rs2506028 that differed in minor allele frequency and the best-supported epistatic model. Intriguingly, rs2506028 is in high LD with one cis-regulatory variant (rs2506030) highlighted previously, suggesting that detected epistasis might be mediated through synergistic effects on transcription regulation of RET. Our findings demonstrated the advantages of WGS data for detecting epistasis, and support the presence of interactive effects of regulatory variants in RET for HSCR.
Assessing the potential of solubility trapping in unconfined aquifers for subsurface carbon storage
Authors: Addassi Mouadh , Omar Abdirizak , Hoteit Hussein , Afifi Abdulkader M. , Arkadakskiy Serguey , Ahmed Zeyad T. , Kunnummal Noushad , Gislason Sigurdur R. , Oelkers Eric H.
Published: November 2022

Carbon capture and storage projects need to be greatly accelerated to attenuate the rate and degree of global warming. Due to the large volume of carbon that will need to be stored, it is likely that the bulk of this storage will be in the subsurface via geologic storage. To be effective, subsurface carbon storage needs to limit the potential for CO2 leakage from the reservoir to a minimum. Water-dissolved CO2 injection can aid in this goal. Water-dissolved CO2 tends to be denser than CO2-free water, and its injection leads immediate solubility storage in the subsurface. To assess the feasibility and limits of water-dissolved CO2 injection coupled to subsurface solubility storage, a suite of geochemical modeling calculations based on the TOUGHREACT computer code were performed. The modelled system used in the calculations assumed the injection of 100,000 metric tons of water-dissolved CO2 annually for 100 years into a hydrostatically pressured unreactive porous rock, located at 800 to 2000 m below the surface without the presence of a caprock. This system is representative of an unconfined sedimentary aquifer. Most calculated scenarios suggest that the injection of CO2 charged water leads to the secure storage of injected CO2 so long as the water to CO2 ratio is no less than ~ 24 to 1. The identified exception is when the salinity of the original formation water substantially exceeds the salinity of the CO2-charged injection water. The results of this study indicate that unconfined aquifers, a generally overlooked potential carbon storage host, could provide for the subsurface storage of substantial quantities of CO2.
Analysis of medical service utilization for post-stroke sequelae in Korea between 2016 and 2018: a cross-sectional study
Authors: Lee Hyun-Jun , Lim Yu-Cheol , Lee Ye-Seul , Kwon Seungwon , Lee Yoon Jae , Ha In-Hyuk
Published: November 2022

In this retrospective cross-sectional observational study, the medical service utilization of post-stroke sequelae patients was examined using a national patient sample. The Korean Health Insurance Review and Assessment Service-National Patients Sample database was used to investigate the medical service utilization of 19,562 patients, diagnosed with post-stroke sequelae of cerebrovascular disease (I69) in Korea between January 2016 and December 2018. We compared the demographic characteristics, diagnosis code subtypes, frequency of healthcare utilization, medical costs, and comorbidities of standard care (SC) and Korean medicine (KM) users. Overall, patients aged ≥ 65 years accounted for the highest percentage, and utilization of medical services increased among patients aged ≥ 45 years. Outpatient care was higher among SC (79.23%) and KM (99.38%) users. Sequelae of cerebral infarction accounted for the highest percentage of diagnosis subtypes. Physical therapy and rehabilitation therapy were most frequent in SC, whereas injection/procedure and acupuncture were most frequent in KM. Cerebrovascular circulation/dementia drugs were prescribed most frequently in SC. Circulatory, digestive, endocrine, and metabolic disorders were the most common comorbidities in SC, whereas musculoskeletal and connective tissue disorders were most common in KM. Overall, SC and KM users showed differences in the number of medical service claims, cost of care, and comorbidities. Our findings provide basic research data for clinicians, researchers, and policy makers.
Application of second-generation sequencing in congenital pulmonary airway malformations
Authors: Zhang Gang , Cai Chun , Li Xiao , Lou Lei , Zhou Bin , Zeng Huiyi , Yan Xiangang , Liu Dandan , Yu Gang
Published: November 2022

To investigate the differential expression of genes in whole transcripts of congenital pulmonary airway malformation (CPAM) using second-generation sequencing (also known as next-generation sequencing, NGS) technology. Children with CPAM were strictly screened after setting the criteria, and grouped by taking CPAM parietal tissue and CPAM lesion tissue respectively, and RNA-Seq libraries were established separately using second-generation sequencing technology, followed by differential expression analysis and GO (gene ontology) functional enrichment analysis, KEGG (Kyoto encyclopedia of genes and genomes, a database) pathway analysis and GSEA (Gene Set Enrichment Analysis) analysis. Five cases were screened from 36 children with CPAM, and high-throughput sequencing was performed to obtain 10 whole transcripts of samples with acceptable sequence quality and balanced gene coverage. One aberrantly expressed sample (3b) was found by analysis of principal components, which was excluded and then subjected to differential expression analysis, and 860 up-regulated genes and 203 down-regulated genes. GO functional enrichment analysis of differentially expressed genes demonstrates the functional class and cellular localization of target genes. The whole transcript of CPAM shows obvious gene up and down-regulation, differentially expressed genes are located in specific cells and belong to different functional categories, and NGS can provide an effective means to study the transcriptional regulation of CPAM from the overall transcriptional level.
Study on time effect of residual pressure and bearing characteristics of jacked pile in saturated silt foundation
Authors: Jiu Yong-Zhi , Zhang Xiang-Yu , Zhu Yan-zhi , Zhang Zhen , Tian Guang-hui
Published: November 2022

The history of stress in soil mass and pile surface roughness significantly impacts the time effect of residual pressure at the pile end and bearing characteristics of the jacked pile. In this study, the impacts of soil over-consolidation ratio and pile surface roughness on the time effect of residual pressure and bearing characteristics of jacked pile end in saturated silt foundation are explored. Through the independently developed model test device for the vertical bearing characteristics of jacked pile, the driving of jacked pile with different pile surface roughness and static load tests at different resting phases are carried out on saturated silt foundations with different over-consolidation ratios. The model box is cylindrical in shape with a size of 40 cm × 48 cm (inner diameter × height) and is made of transparent tempered glass. The results show that: the increase in surface roughness of jacked pile in saturated silt foundation causes not only the increase in the pile side friction but also the increase in the pile end resistance during the static pressure sinking pile; the change laws on the residual pressure of pile end and limit friction resistance of pile side for jacked pile in saturated silt foundation vary with over-consolidation ratio of soil mass and the pile surface roughness.
Combining tetraphenylethene (TPE) derivative cations with Eu3+-β-diketone complex anions for tunable luminescence
Authors: Han Jicao , Zhang Zhengyu , Liu Dongdong , Wang Xi
Published: November 2022

A novel dual energy transfer system was constructed through the combination of tetraphenylethene (TPE) derivative cations and Eu3+-β-diketone complex anions.
Double butterfly-shaped octanuclear dysprosium clusters: structure, magnetism and assembly mechanism
Authors: Li Yun-Lan , Huang Zhong-Ming , Wang Hai-Ling , Zhu Zhong-Hong , Liang Fu-Pei , Zou Hua-Hong
Published: November 2022

This is the first time to explore the self-assembly process of double butterfly-shaped lanthanide high-nucleus clusters and propose their possible assembly mechanism.
Highly dispersed RuCo clusters on N-doped carbon shell for Li–O2/CO2batteries and exploitation of the synergistic effect of O2and CO2
Authors: Lian Yuebin , Xiao Long , Yang Xiaoyu , Xu Weilong , Du Xiaojiao , Hong Yilun , Zheng Min , Peng Yang
Published: November 2022

The respective roles of O2and CO2in Li–O2/CO2batteries are investigated and the capacity current rate gas composition relationship is elucidated.
Cytotoxic alkaloids from the twigs and leaves of Cephalotaxus sinensis
Authors: Zhang Fuxin , Yang Tao , Yang Kailing , Zhou Ruixi , Zhang Yu , Chen Wenwen , Liu Zhetong , Zhan Guanqun , Guo Zengjun
Published: November 2022

Twelve new Cephalotaxus alkaloids with cytotoxic activities from the twigs and leaves of Cephalotaxus sinensis.
Simulation time analysis of kinetic Monte Carlo algorithmic steps for basic radical (de)polymerization kinetics of linear polymers
Authors: Trigilio Alessandro D. , Marien Yoshi W. , Edeleva Mariya , D'hooge Dagmar R. , Van Steenberge Paul H. M.
Published: November 2022

Data structures and algorithms for distributed species allowing to minimize kinetic Monte Carlo simulation times are presented.
One‐step synthesis of silver nanostructures using Heracleum persicum fruit extract, their cytotoxic activity, anti‐cancer and anti‐oxidant activities
Authors: Dehnoee Ali , Javad Kalbasi Roozbeh , Zangeneh Mohammad Mahdi , Delnavazi Mohammad‐Reza , Zangeneh Akram
Published: November 2022

Bio‐inspired techniques are used for synthesis in terms of application, green chemical research, facile, and eco‐friendly chemistry study of silver nanostructures utilizing plant extracts as natural reducing/stabilization and solid adjuvants without the use of toxic and damaging reagents. The present study investigates the biosynthesis of Ag nanoparticles via the mediation of the methanolic extract of Heracleum persicum seeds, without utilizing any stabilizer or surfactant. These nanostructures were identified utilizing ultraviolet–visible spectroscopy, field emission scanning electron microscopy, energy‐dispersive X‐ray spectroscopy, X‐ray diffraction, high‐resolution transmission electron microscopy, Fourier‐transform infrared spectroscopy and dynamic light scattering. The attributes of AgNPs versus usual human breast adenocarcinoma cell lines that is, Hs 281.T, MDA‐MB‐468, AU565 [AU‐565], MCF7, CAMA‐1, SK‐BR‐3, NMU, and RBA were evaluated. The livability of breast adenocarcinoma cell line diminishes dose‐dependently in the existence of AgNPs. After clinical studies, AgNPs can be used as a green drug in the treatment of human breast adenocarcinoma.
Heterogeneous information integration method for scheme decision making of industrial design
Authors: YANG Yanpu , AN Weilan , YANG Qinxia , GONG Zheng
Published: November 2022

为有效融合工业设计方案决策中的异构信息, 引入云模型处理定性语言评价, 基于黄金分割方法将语言信息量化为云模型的数字特征, 分别构建语言值、区间数和实数相对优势矩阵。考虑决策过程的模糊性与不确定性, 将决策属性判断的自然语言采用区间标度量化, 构建非线性优化模型求解最优决策属性权重, 以最大似然估计实现群体决策的区间标度集结, 通过综合效用函数计算工业设计方案优劣。以某型指挥用控制台工业设计方案决策为例, 验证了所提方法能够有效融合异构决策信息, 辅助工业设计师和决策者准确把控意见并进行方案优选。
Maisnarben – eine (un)bekannte traditionelle
Arzneidroge
Authors: Perlberg Liesa , Melzig Matthias F.
Published: November 2022

Maisnarben (Stigmata Maydis) sind eine eher unbekannte Arzneidroge, gewonnen von
Zea mays L. Volksheilkundlich und in der Homöopathie wird die
Droge v. a. bei Erkrankungen der ableitenden Harnwege eingesetzt. Neuere
Untersuchungen weisen auf eine Wirksamkeit bei Stoffwechselerkrankungen hin.
Bisher strittig sind phytochemische Untersuchungen zur Anwesenheit von
Alkaloiden, die bisher kaum spezifiziert wurden. Mit den üblichen
Arzneibuch-Detektionsverfahren konnten wir keine Alkaloide detektieren. Erst
Untersuchungen mittels HPLC-MS/MS-Technik lassen die Anwesenheit von
geringen Mengen an Fusarinsäure vermuten, ein
Picolinsäurederivat (Pyridinalkaloid), das beim Befall der Pflanze mit
Fusarium spp. gebildet wird. Da neben der Fusarinsäure auch
Mykotoxine gebildet werden können, sollte auf eine sorgfältige
Qualitätskontrolle vor der Anwendung dieser Droge geachtet werden.
Sehr geehrte Damen und Herren, liebe Mitglieder der
GPT,
Authors: Langhorst Jost
Published: November 2022

kommen Sie im Juni 2023 nach Bamberg!

Seit mehr als 2 Jahren leben wir unter dem Eindruck der COVID-19-Pandemie.
Mittlerweile sind mehr als 35 Millionen akute Infektionen bei Menschen in
Deutschland erfasst worden. In Prävention und akuter Behandlung hat die
Phytotherapie ihren sicher nicht immer ausreichend beachteten und
gewertschätzten Platz.
Architectural characteristics of accommodation buildings within the context of sustainable ecotourism in Cyprus: evaluation and recommendations
Authors: Üzümoğlu Miray Dizem , Turkan Zihni
Published: November 2022

Tourism, a socioeconomic activity generally defined as an exchange of culture, is diversified by its different purposes. Ecotourism, which emerged and has been constantly developing in the last quarter century, is based on the principles of protecting the natural environment and recognising the original local culture in an interaction with the environment. As significant components of tourism activities, accommodation structures play a major role in the realisation of ecotourism. Due to its location, cultural heritage and rich history together with its Mediterranean climate, Cyprus is an especially important tourism destination for people from Middle East and European countries. The traditional living culture in this small island country has created a huge demand for ecotourism in Cyprus. The ecotourism industry in Cyprus provides housing structures restored with the traditional architectural characteristics of the island as well as new buildings. The new accommodation structures should be constructed in compliance with the traditional architectural characteristics of Cyprus to contribute to the island’s cultural tourism. Our study was conducted through a literature review regarding the main concepts of tourism and ecotourism and on-site field work on the architectural characteristics of existing ecotourism accommodation structures located in the ecotourism villages of Cyprus. In consideration of the field study findings, this study also proposes recommendations that could be a model for the architectural characteristics of new accommodation structures to be constructed for sustainable ecotourism in Cyprus. Within the framework of our study, the location, construction date, and architectural characteristics of fifteen accommodation structures were selected from Cyprus ecotourism villages; their layout and sketch drawings were completed using measurements and observations, while outdoor-indoor photographs were taken. As a result of these findings and based on the common architectural characteristics of existing ecotourism accommodation structures, the architectural characteristics of future accommodation structures have been identified accordingly.
Vulnerability and fraud: evidence from the COVID-19 pandemic
Authors: Zhang Yun , Wu Qun , Zhang Ting , Yang Lingxiao
Published: November 2022

This study examines consumer fraud at the onset of the COVID-19 pandemic and provides novel evidence for the opportunity model of predatory victimization. Scammers have taken advantage of the COVID-19 pandemic shock to exploit victims who are already vulnerable and suffering. The number of fraud cases has greatly increased as COVID-19 spread across the U.S., consistent with the vulnerable-to-become-victimization hypothesis based on the opportunity model of predatory victimization. A Google Trends analysis shows that the increase in fraud and scams is attributable to victims’ increased vulnerability rather than to their awareness of fraud and increased motivation to report scams. An improvement in financial literacy is associated with the reduction of finance-related fraud and scams. Finally, we provide important policy implications to protect people from fraud victimization.