bluuebunny/crossref_metadata_2025 huggingface dataset:
Mania as a Rare Adverse Event Secondary to Steroid Eye Drops
Authors: Alsalem Moayyad , Alharbi Majed A. , Alshareef Rayan A. , Khorshid Raghad , Thabet Salman , Alghamdi Abdulrahman
Published: June 2022

Since glucocorticoids (GCs) were introduced for the treatment of various diseases, they have been linked with the development of psychiatric adverse effects such as mania, depression, and psychosis. These behavioral or psychiatric adverse events usually appear within a few days after commencing GCs and are possibly to reverse with drug withdrawal. We present a rare case of a 75-year-old woman who developed mania during treatment with GC eye drops following cataract surgery. Management consisted of discontinuing prednisolone and administering olanzapine, which resulted in full recovery in a week. Olanzapine was then discontinued, and a diagnosis of steroid-induced mania was concluded for this case.
Mesenchymal Stem Cell Therapy: A Potential Treatment Targeting Pathological Manifestations of Traumatic Brain Injury
Authors: Zhang Kaige , Jiang Yiming , Wang Biyao , Li Tiange , Shang Dehao , Zhang Xinwen
Published: June 2022

Traumatic brain injury (TBI) makes up a large proportion of acute brain injuries and is a major cause of disability globally. Its complicated etiology and pathogenesis mainly include primary injury and secondary injury over time, which can cause cognitive deficits, physical disabilities, mood changes, and impaired verbal communication. Recently, mesenchymal stromal cell- (MSC-) based therapy has shown significant therapeutic potential to target TBI-induced pathological processes, such as oxidative stress, neuroinflammation, apoptosis, and mitochondrial dysfunction. In this review, we discuss the main pathological processes of TBI and summarize the underlying mechanisms of MSC-based TBI treatment. We also discuss research progress in the field of MSC therapy in TBI as well as major shortcomings and the great potential shown.
Design and Analysis of Grouting Pressure in Slurry Pipe Jacking Based on the Surrounding Soil Stability Mechanical Characteristics
Authors: Liu Jimin , Cheng Hua , Cai Haibing , Wang Xuesong
Published: June 2022

In slurry pipe jacking, lubricant slurry is commonly used to sustain against the displacement and pressure of the overcut area and reduce the interface friction of pipelines. Therefore, a reasonable grouting pressure should ensure the stability of surrounding soils, which is raised as a new method in this study. Not only ensure the grouting pressure is not too small to support the stratum effectively and reduce the frictional resistance but also ensure that the grouting pressure will not be too large to produce excessive deformation and affect the surrounding environment. First of all, the influence of grouting pressure on the stability of surrounding soil is analyzed, and the mechanical model of slurry grouting expansion is established. Then, the minimum grouting pressure is designed from the critical balance between radial expansion tension by grouting and loose earth pressure by jacking excavation, and the maximum grouting pressure is designed from the critical expansion pressure caused by grouting splitting. Finally, the rationality of grouting pressure design is proved by the engineering example of a slurry pipe-jacking project near Haikou Meilan Airport and on-site GPR detection test. All these work aims to raise a new theoretical solution of grouting pressure and provide theoretical reference for similar projects.
NCOA4: An Immunomodulation-Related Prognostic Biomarker in Colon Adenocarcinoma and Pan-Cancer
Authors: Gu Chenzheng , Chang Wenjing , Wu Junlu , Yao Yiwen , Liu Gege , Yuan Yi , Quan Wenqiang , Sun Zujun , Shang Anquan , Li Dong
Published: June 2022

Treatment of cancer in humans requires a thorough understanding of the multiple pathways by which it develops. Recent studies suggest that nuclear receptor coactivator 4 (NCOA4) may be a predictive biomarker for renal cancer. In the present work, TCGA, GEPIA, and several bioinformatics approaches were used to analyze the NCOA4 expression patterns, prognostic relevance, and association between NCOA4 and clinicopathological features and immune cell infiltration. We investigated NCOA4 expression in malignancies. Low NCOA4 expression was associated with poor overall survival in individuals with malignancies such as cholangiocarcinoma, colon adenocarcinoma, and clear cell renal carcinoma. We also analyzed NCOA4 DNA methylation in normal and primary tumor tissues and investigated possible functional pathways underlying NCOA4-mediated oncogenesis. In conclusion, downregulation of NCOA4 is associated with poor prognosis, and NCOA4 may be a predictive biomarker for COAD.
Analysis of the Relationship between Transformational Leadership and Educational Management in Higher Education Based on Deep Learning
Authors: Meng Haiying
Published: June 2022

Leadership behavior has been emphasized as one of the most important influencing factors in the innovation process. Leaders can encourage subordinates to innovate by creating the right environment, promoting knowledge integration, and setting specific goals. However, different leadership styles make different decisions and behaviors in the innovation process, and the final innovation effect is also different. Today, in the context of China, most business leaders still adopt “paternalistic” or “authoritarian” leadership behaviors, but more and more entrepreneurs and scholars are aware of the importance of this leadership style in enhancing employee creativity. Authoritarian leaders are more likely to exercise more control and supervision over team members, limit the autonomy of team members, and reduce work initiative and creativity. Although the positive effect of transformational leadership on employee creativity has been recognized by some scholars, in the real work environment, this leadership style rarely appears, especially in the context of China. This study first constructs a theoretical model of how transformational leaders in colleges and universities affect educational management innovation through the atmosphere of school organizational innovation, based on the deep learning theory and other related research results, and then puts forward research hypotheses on this basis. Secondly, a measurement scale was designed according to the existing research results, and the scale was revised through the pretest to form the formal questionnaire of this study. This research uses cluster sampling and random sampling to conduct a questionnaire survey on 1022 college teachers and uses the SPSS20.0 and AMOS21.0 to conduct an empirical analysis on the survey data. Each measurement scale was tested by exploratory factor analysis and confirmatory factor analysis. The experimental results show that the transformational leadership style of college principals has a positive impact on teachers’ teaching innovation. There is a positive correlation between the influence of charisma and teachers’ teaching management, and there is a positive correlation between intellectual stimulation and teachers’ teaching management.
Application of Chain Nursing Process in the Nursing of Elderly Inpatients with Implantable Venous Infusion Port
Authors: Hu Juan , Zhou Li , Ding Juanying
Published: June 2022

Objective. To explore the application effects of chain nursing process in the nursing of elderly inpatients with implantable venous infusion port. Methods. 81 elderly inpatients who were treated with implantable venous infusion port in the hospital were selected between February 2018 and December 2021, and they were divided into the routine group (given routine nursing of implantable venous infusion port, n = 40) and the study group (given chain nursing process intervention on the basis of the routine group, n = 41) according to the random number table method. The patients in both groups were intervened for 1 month. The catheter-related indicators and incidence rates of adverse events (drug extravasation, local hematoma, infusion port blockage, catheter-related infection) were compared between the two groups of patients. Generalized Anxiety Disorder 7-item scale (GAD-7) and Athens Insomnia Scale (AIS) were used to compare the psychological states of the two groups before and after intervention, and Newcastle Satisfaction with Nursing Scale (NSNS) was adopted to compare the nursing satisfaction of patients before and after intervention. Results. After intervention, the catheter maintenance operation time in the study group was shorter than that in the routine group (

P
<
0.05

), and there were no significant differences in the accidental extubation rate and re-intubation rate between the two groups (

P
>
0.05

). The incidence rate of adverse reactions of 2.44% in the study group was lower than 15.00% in the routine group (

P
<
0.05

). After intervention, the scores of GAD-7 and AIS in the two groups were reduced compared with those before intervention, and the above scores in the study group were lower than those in the routine group (

P
<
0.05

). Before intervention, there were no significant differences in the NSNS scores between the two groups (

P
>
0.05

). After intervention, the NSNS scores in the study group were higher than those in the routine group (

P
<
0.05

). Conclusion. Chain nursing process can help to enhance the maintenance quality of implantable venous infusion port, reduce the incidence of adverse events, relieve the tension and anxiety, and improve the satisfaction of patients with nursing.
Serum Concentrations of Cartilage Intermediate Layer Protein 2 Were Higher in Overweight and Obese Subjects
Authors: Li Qinge , Pu Danlan , Xia Xuyun , Liu Hua , Li Ling
Published: June 2022

Background. Cartilage intermediate layer protein 2 (CILP2) is associated with a variety of plasma lipoproteins and lipid traits. However, the correlation between CILP2 and obesity remains unknown. The aim of this study was to investigate the relationship between circulating CILP2 levels and obesity based on body mass index (BMI). Methods. A total of 252 subjects were divided into three groups: normal weight (n = 124), overweight (n = 94), and obese (n = 34). Metabolic parameters were measured in a fasting state. Serum CILP2 concentration was tested by enzyme‐linked immunosorbent assay. Multivariate linear regression analysis was used to explore the relationship between CILP2 and obesity. We also conducted bioinformatics analysis to further explore the genes and signaling pathways related to CILP2. Results. The concentrations of serum CILP2 in the overweight and obese groups were significantly higher than that in the normal weight group. In multiple linear regression analysis, BMI was positively correlated with CILP2 concentration after controlling gender and age. Being overweight and obese were independently correlated with CILP2 concentration after adjusting for gender, age, SBP, DBP, FBG, 2‐hour OGTT blood glucose (2h‐BG), fasting blood insulin (FIns), TG, TC, HDL‐C, LDL‐C, and FFA. Bioinformatics analysis showed that the genes related to CILP2 are primarily associated with lipid metabolism and insulin resistance. Conclusion. We speculate that CILP2 may attribute to metabolic disorders in obesity.
Effect of Tetracycline Antibiotics on Anaerobic Digestion of Chicken Manure Based on Data Mining
Authors: Zhai Haiqi , Qiang Hong
Published: June 2022

Although anaerobic bioengineering treatment of chicken manure has the advantages of low energy consumption, less pollution, and recyclable biomass energy, antibiotics are usually added in the process of modern intensive farming. And antibiotics still exist in feces and pose a threat to human health. Therefore, this study aimed to deeply understand the role of TC in the anaerobic digestion of chicken manure and to analyze the effect of tetracycline antibiotics on the anaerobic digestion of chicken manure based on data mining. In this study, chicken manure was used as raw material for anaerobic fermentation, and the effects of tetracycline (TC) on anaerobic and anaerobic fermentation of chicken manure were compared through batch and sequence experiments. Also, this study analyzes the fermentative transformation to elucidate the effect of TC on anaerobic manure conversion in chicken manure, which further studies the effect of TC on the anaerobic fermentation of chicken manure. The experimental results in this study show that when the TC concentration is 50–150 mg/L, the content of tryptophan and tyrosine proteins in the treatment group is also higher than that in the control group. It shows that at low concentrations (10, 25 mg/L), TC mainly promotes the degradation of LEPS by promoting the dissolution of intracellular substances in the sludge. With the increase of TC concentration (50–300 mg/L), TC mainly promotes the breakdown of the sludge cell membrane by promoting the rupture of the sludge cell membrane, thereby promoting the degradation of LEPS.
An Information Retrieval Algorithm for Accounting Internal Audit Using Multi-Pattern Similarity Matching
Authors: Ma Chunguang , Bei Hongjun , Chen Guihua , Gao Jianhui
Published: June 2022

The multi-mode matching has noteworthy transformations equated with the classical multi-mode matching algorithms. It is frequently used for the policy part of the TCP connection to connect the English characters. In this article, we analyzed the features of multi-mode similarity for audit information retrieval in a cluttered environment. The proposed model analyzed the performance theorem of a multi-mode matching algorithm for audit information retrieval. It also analyzed the shortcomings of existing multi-mode similarity systems and proposed a multi-mode algorithm based on the trail hash trie matching machine suitable for mixed Chinese and English environments. The algorithm converts the set of pattern strings into multiple finite automata and then builds a state driver using the set of pattern strings. The state driver is driven by the characters of the string to be matched in turn, and each finite automaton is driven by the state driver to achieve similar multimodal matching with mixed English and Chinese characters by allowing the insertion errors. The algorithm does not need to match every character and can make full use of the information of this unsuccessful match during the matching process and skip as many characters as possible by combining the improved text window mechanism. It can control the upper limit of allowed errors for each pattern string. The matching speed is independent of the number k of allowed insertion errors. The algorithm has comprehensive application projections in the fields of information auditing, database, and information retrieval, respectively.
Efficacy Assessment of Phentolamine Accompanied by Lidocaine Subcutaneously under Ultrasound Guidance on Radial Artery Catheterization in Pediatric Patients
Authors: Kong Erliang , Shu Lun , Yuan Chang , Wang Jianxin , Wu Feixiang , Yuan Hongbin , Feng Xudong
Published: June 2022

Objective. Pediatric patients are facing greater difficulties in radial catheterization for anatomic variation and smaller diameter. This study is to investigate the efficacy of phentolamine accompanied by lidocaine subcutaneously under ultrasound guidance on radial catheterization in pediatric patients. Methods. 66 pediatric patients were enrolled and randomly divided into saline group, phentolamine group, and phentolamine+lidocaine group. Baseline characteristics and surgical types were collected. Relevant solutions were subcutaneously injected, and catheterization was subsequently conducted under ultrasound guidance. Radial artery diameter and depth were measured, the success rate of catheterization and procedure time were calculated, and the complications were evaluated with ultrasonography. Results. No significant differences were observed in age, sex, weight, American Society of Anesthesiologists’ classification, systolic blood pressure, diastolic blood pressure, heart rate, hemoglobin, and surgical types among three groups. Subcutaneously, the diameter in phentolamine and phentolamine+lidocaine groups increased significantly compared with the saline group. Moreover, the diameter also increased significantly after injection compared with that before injection both in the phentolamine and phentolamine+lidocaine groups. The first‐attempt success rates were significantly higher while the procedure times of cannulation were shorter in the phentolamine and phentolamine+lidocaine groups than that in the saline group. Kaplan–Meier analysis showed that the overall procedure time was shorter in the phentolamine and phentolamine+lidocaine groups than the saline group. Overall complications and vasospasm incidence were lower in the phentolamine and phentolamine+lidocaine groups than the saline group. Conclusion. Phentolamine accompanied by lidocaine subcutaneous injection under ultrasound guidance improved the first‐attempt success rate and reduced the complication of radial artery catheterization in pediatric patients.
Laparoscopic versus Conventional Surgery for Acute Cholangitis of Severe Type: A Systematic Review of Randomized Controlled Trials
Authors: Zhang Fang , Huang Jianjiang , Yang Jie , Wang Yuyu , Qiu Bin
Published: June 2022

Objective. Currently, the choice between laparoscopic surgery and conventional laparotomy in the surgical treatment of acute cholangitis of severe type (ACST) is debatable. This study compared the clinical efficacy of these two surgical methods through a meta-analysis based on relevant clinical randomized controlled trials (RCT) on ACST. Methods. We systematically searched several databases (PubMed, Web of Science, Embase, China National Knowledge Infrastructure, and WangFang) for RCT on the surgical treatment of ACST between 2010 and 2022. Relevant data were extracted, and a meta-analysis was performed using the statistical software Stata 16.0. Results. From initial 1089 studies retrieved, 15 studies (

n
=
1247

patients) were eligible. The total number of patients was 1247, of whom 635 were classified in the treatment group (laparoscopic surgery) and 612 patients in the control group (conventional laparotomy). This meta-analysis showed that compared with conventional laparotomy, laparoscopic surgery was associated with higher effective rate (

OR
=
3.808

, 95% CI [2.383, 6.085],

P
<
0.001

), lower incidence rate of complications (

OR
=
0.192

, 95% CI [0.139, 0.265],

P
<
0.001

), shorter operation duration (

SMD
=
−
3.274

, 95% CI [-4.503, -2.045],

P
<
0.001

), and shorter postoperative hospital stay (

SMD
=
−
2.432

, 95% CI [-2.988, -1.877],

P
<
0.001

). Further, the indicators of symptomatic relief (anus exhaust time, jaundice relief time, gastrointestinal function recovery time, and abdominal pain relief time) and inflammatory levels (white blood cell count, alanine aminotransferase, total bilirubin level, and high-sensitivity C-reactive protein level) in the treatment group were better than those in the control group. Conclusion. Laparoscopic surgery was associated with significant improvement in treatment efficiency, reduced risk of complications, and better treatment outcomes in patients with ACST.
Effects of Dietary Lipid Levels on the Lipid Deposition and Metabolism of Subadult Triploid Rainbow Trout (Oncorhynchus mykiss)
Authors: Meng Yuqiong , Tian Haining , Hu Xuemin , Han Buying , Li Xiaohua , Cangzhong Li , Ma Rui
Published: June 2022

A growth trial was conducted to evaluate the effects of dietary lipid levels on the lipid deposition and metabolism of subadult triploid rainbow trout. Diets with low (148 g lipid kg-1 diet), moderate (228 g lipid kg-1 diet), and high (294 g lipid kg-1 diet) crude lipid contents were fed to quadruplicated groups of fish (

233
 
g
±
0.2
 
g

) for 80 days, and they were named as LL, ML, and HL, respectively. Results showed that the lowest and highest values of condition factor and hepatosomatic index were shown in the LL group, respectively, while the HL group obtained the highest liver redness value, plasma total cholesterol, high-density lipoprotein-cholesterol, and low-density lipoprotein-cholesterol contents (

P
<
0.05

). The viscerosomatic index and plasm glucose, nonesterified fatty acids, and triglyceride contents were comparable among groups (

P
>
0.05

). As for lipid deposition, viscera and muscle were the main lipid storage place for triploid rainbow trout when tissues’ weight is taken into consideration. Overall quantitative PCR showed that the lipid uptake, triglyceride, and fatty acid catabolism were upregulated, but glycolysis was downregulated as dietary lipid increased. The expression of genes involved in lipogenesis, lipoprotein clearance, very low-density lipoprotein assembly, and glycogenesis was not affected by dietary lipid levels (

P
>
0.05

). In summary, subadult triploid rainbow trout store lipid mainly in viscera and muscle; it could maintain hepatic lipid homeostasis when fed with dietary lipid levels ranging from 150 to 300 g kg-1 by regulating lipid uptake and switching energy supply between glycolysis and fatty acids β-oxidation.
Design of an Incremental Music Teaching and Assisted Therapy System Based on Artificial Intelligence Attention Mechanism
Authors: Li Dapeng , Liu Xiaoguang
Published: June 2022

With the continuous updating and advancement of artificial intelligence technology, it gradually begins to shine in various industries, especially playing an increasingly important role in incremental music teaching and assisted therapy systems. This study designs artificial intelligence models from the perspectives of attention mechanism, contextual information guidance, and distant dependencies combined with incremental music teaching for the segmentation of MS (multiple sclerosis) lesions and achieves the automatic and accurate segmentation of MS lesions through the multidimensional analysis of multimodal magnetic resonance imaging data, which provides a basis for physicians to quantitatively analyze MS lesions, thus assisting them in the diagnosis and treatment of MS. To address the highly variable characteristics of MS lesion location, size, number, and shape, this paper firstly designs a 3D context-guided module based on Kronecker convolution to integrate lesion information from different fields of view, starting from lesion contextual information capture. Then, a 3D spatial attention module is introduced to enhance the representation of lesion features in MRI images. The experiments in this paper confirm that the context-guided module, cross-dimensional cross-attention module, and multidimensional feature similarity module designed for the characteristics of MS lesions are effective, and the proposed attentional context U-Net and multidimensional cross-attention U-Net have greater advantages in the objective evaluation index of lesion segmentation, while being combined with the incremental music teaching approach to assist treatment, which provides a new idea for the intelligent assisted treatment approach. In this paper, from algorithm design to experimental validation, both in terms of accuracy, the operational difficulty of the experiment, consumption of arithmetic power, and time cost, the unique superiority of the artificial intelligence attention-based combined with incremental music teaching adjunctive therapy system proposed in this paper can be seen in the MS lesion segmentation task.
Power Analysis Attack Based on Hamming Weight Model without Brute Force Cracking
Authors: Fan Xiaohong , Tong Jianmin , Li You , Duan Xiaoyi , Ren Yu
Published: June 2022

Power analysis attack is an attack method to obtain the key in cryptographic chip by analyzing the power information of the cryptographic chip. Machine learning has been widely used in power analysis attacks in recent years. Machine learning can effectively establish the model between the power traces and the SBOX output value or the HM (Hamming) weight of the SBOX output value so that the SBOX output value or the HM weight of the SBOX output value can be obtained through the power traces. HM weight model is widely used because it has less classification of nine and can achieve better machine learning accuracy. However, in the HM weight model, the key cannot be obtained directly by obtaining the median HM weight; instead, the key needs to be deduced by brute force cracking of the median HM weight. Usually, the brute force cracking of a byte key requires 51 enumeration times on average. The HM weight distribution of the SBOX output value is unbalanced, so the power analysis attack based on the HM weight model without brute force cracking is proposed in this paper. Based on the HM weight of the SBOX output value, the method selects the best plaintext for the next power analysis attack, and Euclidean distance is chosen as the optimal plaintext selection judgment algorithm. It makes the HM weight distribution of the SBOX output value more evenly, thus reducing the possible key space and confirming the key more easily. This scheme does not require brute force cracking. It only needs to input 3.332 plaintexts on average and up to 4 plaintexts to determine the unique key, which effectively improves the efficiency of the power analysis attack. In this paper, the authors test the DPA competition V4 data set and Kizhvatov’s data set with random defense. Experiments show that this scheme enjoys the high accuracy of the HM weight model in machine learning. Compared with the Whole Byte scheme, the accuracy based on this scheme can be increased by about 360%. Compared with the brute force cracking HM weight scheme, the guessing entropy can be decreased by about 1700%.
An Exponentially Fitted Numerical Scheme via Domain Decomposition for Solving Singularly Perturbed Differential Equations with Large Negative Shift
Authors: Ejere Ababi Hailu , Duressa Gemechis File , Woldaregay Mesfin Mekuria , Dinka Tekle Gemechu
Published: June 2022

In this study, we focus on the formulation and analysis of an exponentially fitted numerical scheme by decomposing the domain into subdomains to solve singularly perturbed differential equations with large negative shift. The solution of problem exhibits twin boundary layers due to the presence of the perturbation parameter and strong interior layer due to the large negative shift. The original domain is divided into six subdomains, such as two boundary layer regions, two interior (interfacing) layer regions, and two regular regions. Constructing an exponentially fitted numerical scheme on each boundary and interior layer subdomains and combining with the solutions on the regular subdomains, we obtain a second order ε‐uniformly convergent numerical scheme. To demonstrate the theoretical results, numerical examples are provided and analyzed.
Probabilistic Statistics-Based Endurance Life Prediction of Bridge Structures
Authors: Zhang Yanan
Published: June 2022

With the massive construction of bridge infrastructures, bridge health monitoring systems have gradually matured in application and research, but previous research has primarily focused on structural damage detection and bridge safety warnings based on valid data. The structural details of steel bridge panels and structural systems are determined by the coupling effects of many intrinsic and extrinsic uncertainties, such as material properties, structural characteristics, manufacturing processes, and random traffic loads. The evaluation of fatigue is a difficult task. This article first builds a big data platform, utilizing its high-efficiency parallel computing capability and highly fault-tolerant distributed file system to achieve second-level monitoring data processing; ensuring real-time data cleaning, data analysis, and safety warning; and building a big data analysis and processing platform with high reliability, high availability, high storage efficiency, and high scalability of bridge health monitoring. The big data platform chooses HDFS for offline data storage and Spark for data analysis and modelling after comparing and analysing the benefits and drawbacks of various big data technologies. Kafka is used for caching real-time data, and Spark-streaming is used for reading data and real-time processing. Finally, the platform’s superiority and reliability in terms of offline computing performance, real-time online performance, scalability, and fault tolerance are confirmed through experimental analysis; the optimal data cleaning method is derived by comparing and analysing monitoring data noise, jump point, and drift phenomena. This part of the research is based on bridge temperature data with stable signals and bridge strain data with fluctuating signals, taking into account the influence of different data types; the corresponding data missing repair algorithms are proposed for different types of data to form a complete and general data patching method process. The probabilistic fracture mechanics theory, in comparison to the traditional deterministic fatigue assessment method, can better reflect the essential uncertainty of fatigue problems and is an effective way to assess the fatigue performance of orthotropic steel bridge decks. The goal of data patching is to ensure data recovery accuracy of over 90%, with no patching repair required for monitoring data with too much missing data. The endurance life of bridge structures is predicted using a big data probabilistic statistics approach based on a variety of factors such as material properties, construction characteristics, manufacturing processes, and random traffic loads.
Tissue Surface Adaptation and Clinical Performance of CAD-CAM Milled versus Conventional Implant-Assisted Mandibular Overdenture
Authors: El-Shaheed Noha H. , Lamfon Hanadi A. , Salama Rabab. I. , Faramawy Amira Mohammed Gomaa , Mostafa Aisha Zakaria Hashem
Published: June 2022

Purpose. To evaluate the surface adaptation and maximal biting force of CAD-CAM milled mandibular overdenture (CAD-CAM MOD) compared to conventional compression mold mandibular overdenture (CC MOD). Materials and Methods. Ten completely edentulous subjects with persistent complaints of their complete mandibular dentures were received four dental implants in the anterior mandible. Three months after osseointegration, subjects were randomly received either conventional compression mold or CAD-CAM MOD in a crossover design. To assess tissue surface adaptation, the fitting surfaces of each denture base were scanned and placed on the reference master cast. Three and six months after each overdenture was inserted, clinical performance in the form of maximum biting force was evaluated. Results. The results of this study indicated that the tissue surface adaptation of the CAD-CAM MOD bases was significantly better than the conventional (compression mold technique) processed bases where (P=0.0001). Regarding clinical performance (maximum biting force), the CAD-CAM MOD exhibited better clinical performance (P=0.0001). Conclusions. In denture processing methods, the CAD-CAM overdenture delivered more precise adaption and clinical performance than the compression mold technique.
Ethnozoological Study of Traditional Medicinal Animal Parts and Products Used among Indigenous People of Assosa District, Benishangul-Gumuz, Western Ethiopia
Authors: Kumera Goshu , Tamire Girum , Degefe Gezahegn , Ibrahim Hussein , Yazezew Dereje
Published: June 2022

Traditional medicine is a global practice and depends on locally available natural resources and indigenous knowledge. Animals and their products have been used in the preparation of traditional remedies in various cultures since time immemorial. This study aimed to identify and document traditional medicinal sources from animals and associated indigenous knowledge in Assosa Districts, Benshangul Gumuz region, western Ethiopia, from September 2019 to July 2020 to ensure sustainable utilization of natural resources and biodiversity. A cross-sectional survey design was used to collect ethnozoological information with regard to animals used for medicinal purposes, parts used, ingredients added, ailments treated, method of preparation, mode of administration, dosage and duration of treatment, and the mechanisms of knowledge transfer. A total of 38 animal species were used as medicine to treat over 35 different kinds of human diseases including anatomical, physiological, psychological, and spiritual ailments and veterinary treatment. Over 15 animal species were found to score fidelity level (FL) more than 50%, of which the skin of Crocuta crocuta used for the treatment of evil eye had the highest FL (n = 35, 92.1%), followed by the blood of Sus scrofa domestica for treatment of stomach illness (n = 32, FL∼84.2%), the milk of Equus asinus to treat cough and eye disease (n = 28, Fl∼73.7%). The study area harbors diverse medicinal animals that represent key medical alternatives for local communities. The documentation of this indigenous knowledge of animal-derived medicine and the practice helps in developing strategies for conservations of biological diversities.
Prediction of Tourism Demand in Liuzhou Region Based on Machine Learning
Authors: Li Wenqing
Published: June 2022

Liuzhou is a rich tourism city in China. It is well known for its ethnic and prehistoric culture, folk songs, rare stones, and urban landscape. The demand of tourism in Liuzhou city is increasing day by day. Therefore, a system is needed to accurately predict the increasing demand of tourism in Liuzhou city. For this reason, based on the examination of historical visitor data in natural sites especially in Liuzhou city, this research employs an important machine learning and deep learning approach. The purpose of this study is to identify the consumption patterns and improve prediction, prejudgment, and preparation abilities by incorporating them into an intelligent tourism service platform, preventing visitors from travelling at inconvenient times and providing appropriate suggestions to scenic site managers. In this paper, the Sparse Principal Component Analysis-Long-Short-Term Memory (SPCA-LSTM) model has been updated to the Sparse Principal Component Analysis Convolutional Neural Network Long-Short-Term Memory (SPCA-CNNLSTM) model to accurately predict the tourist traffic during the holidays. Convolutional and pooling layers are added to the network topology to extract the local characteristics of the input data. The data of passenger traffic and influencing factors of Liuzhou scenic area from the months of Sept. 2015 to Nov. 2019 were used as the data set for the experiments. A hybrid-forecasting model is also proposed in the paper, which first removes noise from international crude oil data using compression-aware denoising preprocessing and then combines compression-aware denoising with machine learning using artificial neural network (ANN) and support vector regression (SVR). The experimental result shows that the SPCA-CNNLSTM model predicts better values than the SPCA-LSTM model.
Reliability of Accessibility: An Interpreted Approach to Understanding Time-Varying Transit Accessibility
Authors: Xiao Zhongsheng , Mao Baohua , Xu Qi , Chen Yue , Wei Runbin
Published: June 2022

Variable traffic conditions cause travel time uncertainty and further lead to time-varying accessibility. Most current studies do not fully consider fluctuations in accessibility and use complicated methods that likely overestimate the level of accessibility and hinder the application of accessibility measures. To address this issue, we utilized large-scale open-source data and proposed an interpretation of the reliability of accessibility concept that incorporates reliability, travel time uncertainty, and a cumulative opportunity measure. We examined the reliability of accessibility to Shenzhen, a major city in China, focusing on transit accessibility and job opportunities. The results demonstrate that the reliability of accessibility displays a bimodal distribution along urban railway lines and can be used to calculate the impact of urban railways in terms of punctuality. The new approach illustrates time-varying characteristics in the form of probabilities and provides further guidance on accessibility for governments.
Study on the Changes of Liver and Kidney Function-Related Indicators and Clinical Significance in Patients with OSAHS
Authors: Liu Rongyue , Kong Xiangdong
Published: June 2022

Purpose. To study the changes of liver and kidney function-related indexes in patients with obstructive sleep apnea hypopnea syndrome (OSAHS) and analyze their clinical significance. Method. Ninety OSAHS patients treated in our hospital from April 2019 to April 2021 were selected. According to the apnea-hypopnea Index (AHI), they were divided into mild OSAHS group (5 ≤ AHI < 15 times/h, 35 people), moderate OSAHS group (15 ≤ AHI < 30 times/h, 35 people), and severe OSAHS group (AHI ≥ 30 times/h, 20 people). In addition, 50 healthy people who underwent physical examination in our hospital at the same time were selected as the control group, and the liver and kidney function and polysomnography (PSG)-related indexes of the above subjects were detected, and the comparison between the groups was carried out. Result. The serum BUN and SCR levels of the severe group were significantly higher than those of the moderate group, the moderate group had significantly higher levels than the mild group, and the mild group had significantly higher levels than the control group (

P
<
0.05

). The blood AST level of the severe group was significantly lower than that of the moderate group, the moderate group had a significantly lower level than the mild group, and the mild group had a significantly lower level than the control group (

P
<
0.05

). The blood ALT level of the severe group was significantly higher than that of the moderate group, the moderate group had significantly a higher level than the mild group, and the mild group had a significantly higher level than the control group (

P
<
0.05

). The proportions of abnormal liver and kidney function in the control group, mild group, moderate group, and severe group were significantly different (

P
<
0.05

). The AHI of the severe group was significantly higher than that of the moderate group, the moderate group had a higher value than the mild group, and the mild group had a higher value than the control group (

P
<
0.05

). The ASpO2 and MSpO2 of the severe group were significantly lower than those of the moderate group, the moderate group had significantly lower values than the mild group, and the mild group had significantly lower values than the control group (

P
<
0.05

). Spearman correlation analysis showed that the liver and kidney function indexes of OSAHS patients were significantly correlated with PSG indexes (

P
<
0.05

). Conclusion. Patients with OSAHS will have obvious liver and kidney dysfunction, and the monitoring of liver and kidney function in such patients should be strengthened. If abnormality occurs, early intervention is recommended.
Massive-Scale Data Mining to Enhance Digital Library with Applications in College Education
Authors: Xu Chunyan , Bai Jing
Published: June 2022

The context of digital library has changed from insufficient information to information overload, and its corresponding service mode should also change from “people looking for information” to “information looking for people.” Using a grounded theory approach, this paper extracts 78 initial concepts, 24 basic categories, and 6 main categories by coding and analyzing the raw data obtained from the interviews. On this basis, the relationship path and action mechanism between categories are discovered; based on which a theoretical model of the influence mechanism of digital library intelligent information recommendation service satisfaction is constructed. The research results have shown that, under the moderating effect of user preference, the quality of data mining system, recommendation information quality, recommendation service quality, and recommendation form together have an impact on the satisfaction of digital library intelligent information recommendation service. The results of our work can provide useful reference for the optimization and healthy development of digital library services. Meanwhile, it has some theoretical and practical contributions. How to quickly obtain the information people required from a large amount of information is particularly important. Personalized construction is an inevitable service trend for the development of digital libraries in the new era. We in this paper study the current situation of digital libraries and the development of personalized services in digital libraries. We focus on data mining-related technologies, the development of digital library data exploration technologies, and the provision of Internet application services. The problems in this area were summarized, and the countermeasures were put forward based on this. It can be concluded that the concept of a digital library is not just a collection of data with information management tools, it is an environment that brings together collections, services, and people to support the entire data flow. It converts information into domain knowledge, from creation to dissemination. It guides the process from use to save. The trial registration number is ChiCTR2200055403.
Magnetic Resonance Imaging Assessment of Fatigue Injury during Exercise
Authors: Ai Zhengguo , Li Na , An Jing , Zhang Lei
Published: June 2022

In order to investigate the changes of temporal function metabolism of lumbar and back muscles after exercise, a magnetic resonance imaging- (MRI-) based assessment of fatigue injury during exercise was proposed. A total of 100 healthy adult volunteers were selected, including 48 males and 52 females, aged from 19 to 30 years, with an average age of

24.8
+
2.3

years. They were divided into four groups according to the different time points of 0, 15, 30, and 45 minutes after exercise, with 25 persons in each group. PHILIPS Achieva 3.0 T Tx MRI scanner was used to perform BOLD and T2-mapping before and after exercise in four groups of healthy volunteers. All data were analyzed by statistical software. The results showed that the total CSA of the dorsi extensor muscle group and the CSA value of the dorsi extensor muscle group at different levels at different time points before and after exercise increased slowly in exercise period and decreased rapidly in recovery period. It was verified that BOLD MRI and T2-mapping imaging can indirectly evaluate the trend of CSA water metabolism and blood oxygen level in healthy adults after exercise.
Blockade of B7-H1 and PD-1 by Monoclonal Antibodies Potentiates Cancer Therapeutic Immunity
Authors: Hirano Fumiya , Kaneko Katsumi , Tamura Hideto , Dong Haidong , Wang Shengdian , Ichikawa Masao , Rietz Cecilia , Flies Dallas B. , Lau Julie S. , Zhu Gefeng , Tamada Koji , Chen Lieping
Published: June 2022

Contemporary approaches for vaccination and immunotherapy are often capable of eliciting strong T-cell responses against tumor antigens. However, such responses are not parallel to clinical tumor regression. The development of evasion mechanisms within tumor microenvironment may be responsible for poor therapeutic responses. We report here that constitutive or inducible expression of B7-H1, a B7 family molecule widely expressed by cancers, confers resistance to therapeutic anti-CD137 antibody in mice with established tumors. The resistance is accompanied with failure of antigen-specific CD8+ CTLs to destroy tumor cells without impairment of CTL function. Blockade of B7-H1 or PD-1 by specific monoclonal antibodies could reverse this resistance and profoundly enhance therapeutic efficacy. Our findings support that B7-H1/PD-1 forms a molecular shield to prevent destruction by CTLs and implicate new approaches for immunotherapy of human cancers.
Carnosol Inhibits β-Catenin Tyrosine Phosphorylation and Prevents Adenoma Formation in the C57BL/6J/Min/+ (Min/+) Mouse
Authors: Moran Amy E. , Carothers Adelaide M. , Weyant Michael J. , Redston Mark , Bertagnolli Monica M.
Published: June 2022

Carnosol, a constituent of the herb, rosemary, has shown beneficial medicinal and antitumor effects. Using the C57BL/6J/Min/+ (Min/+) mouse, a model of colonic tumorigenesis, we found that dietary administration of 0.1% carnosol decreased intestinal tumor multiplicity by 46%. Previous studies showed that tumor formation in the Min/+ mouse was associated with alterations in the adherens junctions, including an increased expression of tyrosine-phosphorylated β-catenin, dissociation of β-catenin from E-cadherin, and strongly reduced amounts of E-cadherin located at lateral plasma membranes of histologically normal enterocytes. Here, we confirm these findings and show that treatment of Min/+ intestinal tissue with carnosol restored both E-cadherin and β-catenin to these enterocyte membranes, yielding a phenotype similar to that of the Apc+/+ wild-type (WT) littermate. Moreover, treatment of WT intestine with the phosphatase inhibitor, pervanadate, removed E-cadherin and β-catenin from the lateral membranes of enterocytes, mimicking the appearance of the Min/+ tissue. Pretreatment of WT tissue with carnosol inhibited the pervanadate-inducible expression of tyrosine-phosphorylated β-catenin. Thus, the ApcMin allele produces adhesion defects that involve up-regulated expression of tyrosine-phosphorylated proteins, including β-catenin. Moreover, these data suggest that carnosol prevents Apc-associated intestinal tumorigenesis, potentially via its ability to enhance E-cadherin-mediated adhesion and suppress β-catenin tyrosine phosphorylation.
Particle Irradiation Suppresses Metastatic Potential of Cancer Cells
Authors: Ogata Toshiyuki , Teshima Teruki , Kagawa Kazufumi , Hishikawa Yoshio , Takahashi Yutaka , Kawaguchi Atsuko , Suzumoto Yuko , Nojima Kumie , Furusawa Yoshiya , Matsuura Nariaki
Published: June 2022

Particle radiotherapy such as proton and carbon ion has been producing promising clinical results worldwide. The purpose of this study was to compare metastatic capabilities of malignant tumor cells after irradiation with photon, proton, and carbon ion beams to clarify their ion beam–specific biological effects. We examined the biological properties of highly aggressive HT1080 human fibrosarcoma cells to assess their metastatic processes in terms of cell adhesion capability to extracellular matrix, expression of integrins, cell migration, cell invasive capability, and matrix metalloproteinase-2 activity in vitro. We then assessed the metastatic capabilities of LM8 mouse osteosarcoma irradiated with carbon ion or photon beam in the syngeneic mice. Both proton and carbon ion irradiation decreased cell migration and invasion in a dose-dependent manner and strongly inhibited matrix metalloproteinase-2 activity. On the other hand, lower X-ray irradiation promoted cell migration and invasion concomitant with up-regulation of αVβ3 integrin. For cancer cells treated with carbon ion irradiation, the number of pulmonary metastasis was decreased significantly in vivo. These findings suggest that particle irradiation suppresses metastatic potential even at lower dose, whereas photon irradiation promotes cell migration and invasive capabilities at lower dose level, and provide preclinical evidence that ion beam radiotherapy may be superior to conventional photon beam therapy in possible preventive effects on metastases of irradiated malignant tumor cells.