bluuebunny/crossref_metadata_2025 huggingface dataset:
Bridge Abutment Movement and Approach Settlement — A Case Study and Scenario Analysis
Authors: Rashidi Maria , Zhang Chunwei , Ghodrat Maryam , Kempton Shaun , Samali Bijan , Akbarnezhad Ali , Zhu Limeng
Published: December 2017

Movement of bridge abutment is a significant issue affecting the overall reliability and safety of the structure. However, despite considerable consequences, potential movement of abutment is usually not considered in design of bridges for serviceability and abutments are generally designed as fixed elements. Theoretical analysis of bridge abutment and deck design provides background knowledge of reactions that should be anticipated and accounted for. Case studies of bridges experiencing movements and rotations show that practical outcomes often deviate from theoretical expectations. The research presented in this paper, aims to develop a better understanding of abutment stability from both a design and maintenance point of view. This paper includes an in-depth case study of the Kanahooka Road Overbridge in New South Wales, Australia. The results of a full bridge inspection leading to identification of multiple serviceability issues caused by movement of abutments are presented. Moreover, a systematic methodology is implemented, to identify potential remedial options for treatment of abutment movement. The knowledge gained through this case study has led to the development of a model for the management of abutment movement.
Effect of Differential Ballast Settlement on Dynamic Response of Vehicle–Track Coupled Systems
Authors: Sun Yu , Guo Yu , Chen Zaigang , Zhai Wanming
Published: December 2017

An improved vehicle-track coupled dynamics model that takes into account the differential ballast settlement is presented in this paper. Central to this formulation is an iterative method for acquiring the mapping relationship between the ballast settlement and the deflection of rail and sleepers. The proposed method is validated by comparing the results obtained with those of the finite element method (FEM) and the equilibrium state calculated for the track with the ballast settlement. Using the proposed method and dynamic model, numerical analyses have been performed for the static deflection of the rail and sleepers and for the dynamic response of the vehicle-track coupled system. The results indicate that the upper track structure will settle along with the ballast bed, and sleepers are likely to become unsupported when the settlement amplitude is large or when the settlement wavelength is small. The contact between the sleeper and the ballast bed changes dynamically when the vehicle passes through the settlement area. The ballast settlement has a significant effect on the deformation of the track and sleepers, thereby deteriorating the running safety and ride comfort of the vehicle.
WHEN RELAXATION MEETS ADAPTATION IN COMPLEX ADAPTIVE SYSTEMS: A COMPUTATIONAL STUDY OF TUMORIGENESIS
Authors: LOU YUTING , SHENG QI , CHEN YU
Published: December 2017

In complex adaptive systems (CASs), the relaxation based on intra-individual interactions and the adaptation based on sub-individual variations are two fundamental processes entangled to induce great complexity. We analyze the system evolution under multicellular homeostatic regulations coupled with various mutation strategies in computational tumorigenesis as a typical instance to clarify the coupling effect of relaxation and adaptation in CASs. Through visualizing the system dynamics on a synthesized fitness landscape which results from the superposition of the phase diagram and the individual fitness landscape, we entertain a simple theoretical framework that not only helps analyze our simulated multicellular dynamics but is potentially applicable to a broader class of problems in CASs where relaxation and adaptation intertwine. It is stressed that the nonadaptive relaxation process has the essential role in shaping the selective pressure of adaptation as well as in defining the final state of the evolution, whereas it is the rigidity of mutation strategy that determines the complexity of the dynamical process.
Convergence of a highly accurate quasi-interpolation method for options pricing
Authors: Zhang Shengliang
Published: December 2017

A highly accurate radial basis functions (RBFs) quasi-interpolation method for calculating American options prices has been presented by some researchers, which possesses a high order accuracy compared with existing numerical methods. In this study, we show the convergence of the proposed RBFs quasi-interpolation scheme from the view point of probability. It will be confirmed to be a multinomial tree approach, in which in one time step the underlying stock price can arrive at an infinity of possible values. This helps understand the high-order accuracy of the method.
Recent Advances in Superconductivity and Vortex Matter: Selected Topics
Authors: Misko Vyacheslav R.
Published: December 2017

The more-than-a-century history of superconductivity is marked by a great deal of progress in the understanding of this fascinating phenomenon as well as discovery and design of new superconducting materials and systems with enhanced critical parameters. Despite the achievements in theory, experiment and technology, many questions still remain open related to the mechanisms of superconductivity in so-called unconventional materials and aspects related to applications of superconductors which stimulates continuous research interest in the field. In this short review paper, we discuss some important recent advances in superconductivity and vortex matter made over about the last decade. In particular, we focus on novel iron-based and multigap superconductors and vortex matter in multi-component systems including multiband superconductors and multi-component Bose–Einstein condensates. We also discuss recent advances in manipulating vortex matter in nano-engineered superconducting systems such as non-periodic pinning arrays which can be used as devices that enhance the critical superconducting parameters and thus open new possibilities for applications of superconductors.
JQ1 is a potential therapeutic option for COPD patients with agrin overexpression
Authors: Xiao Zhen , Shu Jing , Zhou Feng , Han Yong
Published: December 2017

Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and death worldwide. It is characterized by chronic pulmonary inflammation and obstructed airflow from the lungs. To date, there is no effective treatment for COPD. The activation of the agrin (AGRN-YAP pathway can promote heart regeneration. Because agrin can induce only mild cardiomyocyte proliferation compared with ERBB2 pathway activation, it might exert pleiotropic effects, such as mitigation of innate inflammation, immune response, and fibrosis. Previously, we demonstrated that several common pathological gene regulatory programs such as innate inflammatory and profibrotic transcriptional networks were shared by COPD and heart failure. In this study, we show that agrin is inversely correlated with COPD development and progression and may exert its effects by suppressing innate inflammation and profibrotic signaling pathways. BET inhibitor JQ1, in line with our previous findings, is a promising therapeutic option in the treatment of patients with COPD. Nevertheless, wet laboratory experiments and clinical trials are needed before its application in clinical practice.
Force-velocity test on a stationary cycle ergometer: methodological recommendations
Authors: Rudsits Briar L. , Hopkins Will G. , Hautier Christophe A. , Rouffet David M.
Published: December 2017

Force-velocity tests performed on stationary cycle ergometers are widely used to assess the torque- and power-generating capacities of the lower limbs. The aim of this study was to identify how testing and modeling procedures influence the assessment of individual torque-cadence and power-cadence relationships. Seventeen males completed 62 ± 16 pedal cycles from six 6-s all-out efforts interspersed with 5 min of rest. True measures of maximal power for a particular cadence were obtained for 24 ± 3 pedal cycles, while power was only 94 ± 3% of the true maximum in 19 ± 5 pedal cycles. Pedal cycles showing maximal levels of power also displayed higher levels of electromyography (EMG: 89 ± 7 vs . 87 ± 7%) and coactivation (34 ± 11 vs . 31 ± 10 arbitrary units), as well as lower variability in crank torque and EMG profiles. Compared with the linear and second-order polynomial models that are traditionally used, a better goodness of fit was obtained when the torque-cadence and power-cadence relationships were predicted using second- and third-order polynomials, respectively. The later modeling procedures also revealed an asymmetry in the power-cadence relationship in most participants (i.e., 15 out of 17) and provided a better estimation of maximal cadence [Cmax: 214 ± 20 revolutions/min (rpm)] from the x-intercept of power-cadence relationships (C0: 214 ± 14 rpm). Therefore, we recommend predicting the individual shapes of torque- and power-cadence relationships using second- and third-order polynomial regressions after having selected pedal cycles during which true measures of cadence-specific maximal power were recorded.

NEW & NOTEWORTHY This study is the first to demonstrate that suboptimal activation of the lower limb muscles accompanied reductions in cadence-specific levels of torque and power produced during a force-velocity test performed on a stationary cycle ergometer. This research is also the first to show that, in most noncyclist participants, torque-cadence relationships are not linear, whereas power-cadence relationships display asymmetric shapes, with power production decreasing rapidly when cadence increases beyond 180 revolutions/min.
Dynamic Changes of Mitochondrial Fusion and Fission in Brain Injury after Cardiac Arrest in Rats
Authors: Li Yi , Tang Qingqin , Wang Peng , Qin Jiahong , Wu Haidong , Lin Jiali , Huang Zitong
Published: December 2017

Mitochondria change their morphology dynamically by continual fusion and fission processes to fulfill their function. However, little is known about the effect of cardiac arrest on mitochondrial dynamics. This study aimed to investigate time-dependent change of the mitochondrial dynamics after brain ischemic injury in rats of cardiac arrest. After resuscitation, obvious neuronal injury, reduced adenosine triphosphate (ATP) levels, excessive reactive oxygen species (ROS) generation, decreased mitochondrial membrane potential (MMP), and increased release of mitochondrial cytochrome c were observed at 12 h and 24 h after cardiac arrest. Moreover, we found that elongation of mitochondria was observed at 4 h after cardiac arrest, whereas fragmented mitochondria were significantly increased, along with concomitant increase in the fission proteins Drp1 and Fis1 and a reduction in the fusion proteins Mfn1 and Mfn2 at 12 h and 24 h after cardiac arrest. Taken together, these findings suggest that imbalance in mitochondrial dynamics probably contributes to brain injury after cardiac arrest.
Route of Injection Affects the Impact of InlB Internalin Domain Variants on Severity ofListeria monocytogenesInfection in Mice
Authors: Sobyanin Konstantin A. , Sysolyatina Elena V. , Chalenko Yaroslava M. , Kalinin Egor V. , Ermolaeva Svetlana A.
Published: December 2017

The facultative intracellular pathogenListeria monocytogenescauses a severe food-borne infection in humans and animals.L. monocytogenesinvasion factor InlB interacts with the tyrosine kinase c-Met via the N-terminal internalin domain. Previously, distinct variants of the InlB internalin domain (idInlB) have been described inL. monocytogenesfield isolates. Three variants were used to restore full-length InlB expression in theL. monocytogenesstrain EGDeΔinlB. Obtained isogenicL. monocytogenesstrains were tested in the invasion assay and intravenous, intraperitoneal, and intragastric models of infection in mice. All idInlBs were functional, restored InlB activity as an invasion factor, and improved invasion of the parental strain EGDeΔinlB into human kidney HEK23 cells. Meanwhile, distinct idInlBs provided different mortality rates and bacterial loads in internal organs. When recombinant strains were compared, the variant designated idInlB14 decreased severity of disease caused by intravenous and intraperitoneal bacterial administration, whereas this variant improved intestine colonization and stimulated intragastric infection. Obtained results demonstrated that naturally occurring idInlBs differed in their impact on severity ofL. monocytogenesinfection in mice in dependence on the infection route.
Fundamentals and Methods for T- and B-Cell Epitope Prediction
Authors: Sanchez-Trincado Jose L. , Gomez-Perosanz Marta , Reche Pedro A.
Published: December 2017

Adaptive immunity is mediated by T- and B-cells, which are immune cells capable of developing pathogen-specific memory that confers immunological protection. Memory and effector functions of B- and T-cells are predicated on the recognition through specialized receptors of specific targets (antigens) in pathogens. More specifically, B- and T-cells recognize portions within their cognate antigens known as epitopes. There is great interest in identifying epitopes in antigens for a number of practical reasons, including understanding disease etiology, immune monitoring, developing diagnosis assays, and designing epitope-based vaccines. Epitope identification is costly and time-consuming as it requires experimental screening of large arrays of potential epitope candidates. Fortunately, researchers have developed in silico prediction methods that dramatically reduce the burden associated with epitope mapping by decreasing the list of potential epitope candidates for experimental testing. Here, we analyze aspects of antigen recognition by T- and B-cells that are relevant for epitope prediction. Subsequently, we provide a systematic and inclusive review of the most relevant B- and T-cell epitope prediction methods and tools, paying particular attention to their foundations.
Bipolar Dislocation of the Clavicle: A Report of Two Cases with Different Injury Patterns and a Literature Review
Authors: Okano Ichiro , Sawada Takatoshi , Inagaki Katsunori
Published: December 2017

Bipolar dislocation of the clavicle is a rare injury that is defined as a concomitant dislocation of the ipsilateral acromioclavicular joint and sternoclavicular joint. This injury is also described as a floating clavicle. Although this injury has been known for nearly two centuries, knowledge about it is limited and the treatment strategy remains controversial. Bipolar dislocation includes several combinations of both joints’ injury types. We reported two patients with bipolar dislocation of the clavicle: one with an anterior dislocation and the other with a posterior dislocation of the sternoclavicular joint. After reviewing the currently available literature, we discussed these cases to highlight the necessity of a specific treatment approach that is modified based on the pattern of each joint’s lesion.
Neck Flexion Angle Estimation during Walking
Authors: Dang Duc Cong , Dang Quoc Khanh , Chee Young Joon , Suh Young Soo
Published: December 2017

Neck pain is recently known as the fourth leading cause of disability and the number of patients is apparently increasing. By analyzing the effect of gravitational force on inertial sensor attached to the neck, this study aims to investigate the head flexion posture during walking. The estimated angle is compared with the craniovertebral angle which is measured with an optical tracker. A total of twenty subjects with no history of neck pain or discomfort were examined by walking on the treadmill inside the working range of an optical tracker. In our laboratory settings, the neck flexion angle (NFA) may have a linear relationship with the craniovertebral angle (CVA) in both static case and constant speed walking case. Therefore, inertial sensor, which is lightweight, low cost, and especially free in movement, can be used instead of a camera system. Our proposed estimation method shows its flexibility and gives a result with the mean of absolute error of estimated neck angle varying from 0.48 to 0.58 degrees, which is small enough to use in applications.
Cigarette Smoke Exposure Inhibits Bacterial Killing via TFEB-Mediated Autophagy Impairment and Resulting Phagocytosis Defect
Authors: Pehote Garrett , Bodas Manish , Brucia Kathryn , Vij Neeraj
Published: December 2017

Introduction. Cigarette smoke (CS) exposure is the leading risk factor for COPD-emphysema pathogenesis. A common characteristic of COPD is impaired phagocytosis that causes frequent exacerbations in patients leading to increased morbidity. However, the underlying mechanism is unclear. Hence, we investigated if CS exposure causes autophagy impairment as a mechanism for diminished bacterial clearance via phagocytosis by utilizing murine macrophages (RAW264.7 cells) and Pseudomonas aeruginosa (PA01-GFP) as an experimental model. Methods. Briefly, RAW cells were treated with cigarette smoke extract (CSE), chloroquine (autophagy inhibitor), TFEB-shRNA, CFTR(inh)-172, and/or fisetin prior to bacterial infection for functional analysis. Results. Bacterial clearance of PA01-GFP was significantly impaired while its survival was promoted by CSE (p<0.01), autophagy inhibition (p<0.05; p<0.01), TFEB knockdown (p<0.01; p<0.001), and inhibition of CFTR function (p<0.001; p<0.01) in comparison to the control group(s) that was significantly recovered by autophagy-inducing antioxidant drug, fisetin, treatment (p<0.05; p<0.01; and p<0.001). Moreover, investigations into other pharmacological properties of fisetin show that it has significant mucolytic and bactericidal activities (p<0.01; p<0.001), which warrants further investigation. Conclusions. Our data suggests that CS-mediated autophagy impairment as a critical mechanism involved in the resulting phagocytic defect, as well as the therapeutic potential of autophagy-inducing drugs in restoring is CS-impaired phagocytosis.
Predictors of Women’s Satisfaction with Hospital-Based Intrapartum Care in Asmara Public Hospitals, Eritrea
Authors: Kifle Meron Mehari , Ghirmai Filmon Abraham , Berhe Soliana Amanuel , Tesfay Winta Sium , Weldegebriel Yodit Teklemariam , Gebrehiwet Zebib Tesfamariam
Published: December 2017

Background. Exploring patient satisfaction contributes to provide quality maternity care, but there is paucity of epidemiologic data in Eritrea. Objectives. To determine the predictors of women's satisfaction with intrapartum care in Asmara public maternity hospitals in Eritrea. Methods. A cross-sectional study among 771 mothers who gave birth in three public Hospitals. Chi-square tests were done to analyze the difference in proportion and logistic regression to assess the predictors of satisfaction with intrapartum care. Results. Overall, only 20.8% of the participants were satisfied with intrapartum service. The key predictors of satisfaction with intrapartum care were provision of clean bed and beddings (AOR = 18.87, 2.33–15.75), privacy during examinations (AOR = 10.22, 4.86–21.48), using understandable language (AOR = 8.72, 3.57–21.27), showing how to summon for help (AOR = 8.16, 4.30–15.48), showing baby immediately after birth (AOR = 8.14, 2.87–23.07), control of the delivery room (AOR = 6.86, 2.65–17.75), receiving back massage (AOR = 6.43, 3.23–12.81), toilet access and cleanliness (AOR = 6.09, 3.25–11.42), availability of chairs for relatives (AOR = 5.96, 3.14–11.30), allowing parents to stay during labour (AOR = 3.52, 1.299–9.56), and request for permission before any procedure (AOR = 2.39, 1.28–4.46). Conclusion. To increase satisfaction with intrapartum care, maternity service providers need to address the general maternity ward cleanliness, improve the quality of physical facilities, and sensitize health providers for better communication with clients. Policy makers need to adopt strategies that ensure more women involvement in decision making and consideration of privacy and reassurance needs during the whole delivery process.
Thoracic Paravertebral Mass as an Infrequent Manifestation of IgG4-Related Disease
Authors: Matzumura Kuan Melissa , Rubin Bernard , Meysami Alireza
Published: December 2017

Case. A 50-year-old African American male presented with abdominal pain and significant weight loss. On physical examination, he had parotid and submandibular gland enlargement associated with right eye proptosis. Computed tomography showed a thoracic paravertebral soft tissue mass, enlarged lymph nodes, and ascending aortic aneurysm. Laboratory results were remarkable for elevated total IgG and IgG4 subclass. The submandibular gland pathology revealed chronic sclerosing sialadenitis, with a large subset of inflammatory cells positively staining for IgG4. The histology of the paravertebral mass demonstrated fibrosclerosis with increased lymphocytic infiltrate, associated with increased IgG4 plasma cells. He was diagnosed with immunoglobulin G4-related disease (IgG4-RD). Steroid therapy initially yielded improvement; however, after steroids were stopped, there was disease recurrence. Prednisone was restarted, and the plan was to start him on rituximab. Interestingly, the patient’s brother also had IgG4-RD. Conclusion. IgG4-RD can present as a paravertebral mass which is usually responsive to steroids; however, recurrent and resistant disease can be seen for which steroid-sparing agents such as rituximab should be considered. In addition, to the best of our knowledge, this is the first reported case of IgG4-RD in two family members presenting as a paravertebral mass, highlighting an exciting area for more research in the future.
Experimental Research on the Impact of Ion Exchange and Infiltration on the Microstructure of Rare Earth Orebody
Authors: Wang Xiaojun , Zhuo Yulong , Deng Shuqiang , Li Yongxin , Zhong Wen , Zhao Kui
Published: December 2017

To detect the evolutional characteristics of pore structure in ore leaching process of ion-type rare earth, this paper analyzes the influence mechanism of ion exchange seepage action on the microstructure of orebody, and an experiment for remodeling rare earth saturated samples and ore leaching was designed. Using nuclear magnetic resonance technology obtains the pore structure T2 map of H2O and (NH4)2SO4 solution in the ore leaching process and inverts and reconstitutes the pore structure distribution image. The results of contrastive analysis experiments indicate that impact factors of the ore leaching process on the microstructure of rare earth orebodies include two aspects: solution seepage and ion exchange. The main factor of pore structure distribution is the ion exchange action, determined by a dual effect. The sole action of solution seepage leads to an increase in pore size, which means that pore size structure is changing from small and medium to macro. Ion exchange gives rise to the movement and restructuring of particles, which results in a decrease in pore sizes. The pore structure changes from loose to compact; in the entire ore leaching process, the ion exchange action advances in a layered shape along the direction of seepage, and the chemical replacement and physical seepage alternately impact the microstructure of the orebodies.
Oncocytes in Mucoepidermoid Carcinoma of the Palate: Diagnostic Challenges
Authors: Kumar Rammohan , Natarajan Srikant , Sneha K.S. , Chitra Nunna Sai , Boaz Karen , Manaktala Nidhi
Published: December 2017

The origin of a salivary gland tumour is attributed to cells at various levels of differentiation which present histologically as diverse tissues and cellular patterns. Mitochondria-rich, eosinophilic oncocytes are cells commonly encountered in salivary gland neoplasms. We report a case of mucoepidermoid carcinoma (MEC) in the palate of a 43-year-old female that exhibited a prominent oncocytic component. While the parotid and submandibular glands have been reported as predominant sites for oncocytic MEC (OMEC), the palate and minor salivary glands are rare sites for occurrence. Also, most of the reported cases of OMEC have been histologically of low-grade mucoepidermoid carcinoma with large cystic spaces and good prognosis. In this article, we discuss the differential diagnosis and diagnostic workup of an MEC presenting with oncocytes.
Relationship between Undescended Testis Position and Prevalence of Testicular Appendices, Epididymal Anomalies, and Patency of Processus Vaginalis
Authors: Favorito Luciano A. , Riberio Julio-Junior Helce , Sampaio Francisco J.
Published: December 2017

Objectives. To assess the incidence of testicular appendices (Tas), epididymal anomalies (EAs), and processus vaginalis (PV) patency in patients with undescended testis (UT) according to testicular position and to compare them with human fetuses. Methods. We studied 85 patients (108 testes) with cryptorchidism and compared the features with those of 15 fetuses (30 testes) with scrotal testes. We analyzed the relationships among the testis and epididymis, patency of PV, and the presence of TAs. We used the Chi-square test for statistical analysis (p<0.05). Results. In 108 UT, 72 (66.66%) had PV patent, 67 (62.03%) had TAs, and 39 (36.12%) had EAs. Of the 108 UT, 14 were abdominal (12.96%; 14 had PV patency, 9 TAs, and 7 EAs); 81 were inguinal (75%; 52 had PV patency, 45 TAs, and 31 EAs), and 13 were suprascrotal (12.03%; 6 had PV patency, 13 TAs, and 1 EAs). The patency of PV was more frequently associated with EAs (p=0.00364). The EAs had a higher prevalence in UT compared with fetuses (p=0.0005). Conclusions. Undescended testis has a higher risk of anatomical anomalies and the testes situated in abdomen and inguinal canal have a higher risk of presenting patency of PV and EAs.
Active Fault-Tolerant Control for Wind Turbine with Simultaneous Actuator and Sensor Faults
Authors: Wang Lei , Cai Ming , Zhang Hu , Alsaadi Fuad , Chen Liu
Published: December 2017

The purpose of this paper is to show a novel fault-tolerant tracking control (FTC) strategy with robust fault estimation and compensating for simultaneous actuator sensor faults. Based on the framework of fault-tolerant control, developing an FTC design method for wind turbines is a challenge and, thus, they can tolerate simultaneous pitch actuator and pitch sensor faults having bounded first time derivatives. The paper’s key contribution is proposing a descriptor sliding mode method, in which for establishing a novel augmented descriptor system, with which we can estimate the state of system and reconstruct fault by designing descriptor sliding mode observer, the paper introduces an auxiliary descriptor state vector composed by a system state vector, actuator fault vector, and sensor fault vector. By the optimized method of LMI, the conditions for stability that estimated error dynamics are set up to promote the determination of the parameters designed. With this estimation, and designing a fault-tolerant controller, the system’s stability can be maintained. The effectiveness of the design strategy is verified by implementing the controller in the National Renewable Energy Laboratory’s 5-MW nonlinear, high-fidelity wind turbine model (FAST) and simulating it in MATLAB/Simulink.
The Partial Duplication of the 5′ Segment of KMT2A Revealed KMT2A-MLLT10 Rearrangement in a Boy with Acute Myeloid Leukemia
Authors: Fukushima Hiroko , Nanmoku Toru , Hosaka Sho , Yamaki Yuni , Kiyokawa Nobutaka , Fukushima Takashi , Sumazaki Ryo
Published: December 2017

The duplication of 5′ segment of KMT2A is a rare molecular event in childhood leukemia, and the influence on prognosis is unknown. Here, we report on a boy who developed acute monocytic leukemia. Fluorescence in situ hybridization revealed the duplication of the 5′ segment with 2 normal alleles at KMT2A which was eventually found to be fused with MLLT10. Chemotherapy promptly induced the first complete remission in the patient at our facility, and the patient remained in first complete remission with negative minimal residual disease at 3.5 years from diagnosis. Our case is similar to two previously reported patients who had partial duplication of the 5′ segment of KMT2A with a KMT2A-MLLT10 rearrangement. Further studies and experience with this cryptic translocation may shed more light on the management of acute myeloid leukemia.
The Association between Monocyte Surface CD163 and Insulin Resistance in Patients with Type 2 Diabetes
Authors: Kawarabayashi Reina , Motoyama Koka , Nakamura Miyuki , Yamazaki Yuko , Morioka Tomoaki , Mori Katsuhito , Fukumoto Shinya , Imanishi Yasuo , Shioi Atsushi , Shoji Tetsuo , Emoto Masanori , Inaba Masaaki
Published: December 2017

Aim. To investigate the association between monocyte CD163 and insulin resistance in patients with type 2 diabetes.Methods. One hundred sixty-six patients with type 2 diabetes without inflammatory or chronic kidney disease were recruited. The monocyte CD163 levels were measured by flow cytometry and soluble CD163 (sCD163) by ELISA. Insulin resistance was evaluated by the index of the homeostasis model assessment (HOMA-R).Results. The median sCD163 and monocyte CD163 expression levels were 582.9 (472.4–720.0) ng/ml and 6061 (4486–7876) mean fluorescent intensity (MFI), respectively. In a simple regression analysis, monocyte CD163 was inversely correlated with log [HOMA-R] (r=–0.257,p=0.010), and sCD163 was positively correlated with log [HOMA-R] (r=0.198,p=0.042). In multiple regression analyses, monocyte CD163 was an independent contributor to log [HOMA-R] (β=–0.220,p=0.020) even after adjustment of various clinical factors for HOMA-R (R2=0.281,p=0.001), whereas sCD163 was not.Conclusions. Monocyte surface CD163 expression levels were more significantly associated with insulin resistance than sCD163 in patients with type 2 diabetes, suggesting a novel pathophysiological role of CD163.
Stochastic Volatility Effects on Correlated Log-Normal Random Variables
Authors: Ma Yong-Ki
Published: December 2017

The transition density function plays an important role in understanding and explaining the dynamics of the stochastic process. In this paper, we incorporate an ergodic process displaying fast moving fluctuation into constant volatility models to express volatility clustering over time. We obtain an analytic approximation of the transition density function under our stochastic process model. Using perturbation theory based on Lie–Trotter operator splitting method, we compute the leading-order term and the first-order correction term and then present the left and right skew scenarios through numerical study.
Synthesis and Characterization of Zn-Nix Advanced Alloys Prepared by Mechanical Milling and Sintering at Solid-State Process
Authors: Miranda-Hernández José G. , Herrera-Hernández Héctor , González-Morán Carlos O. , Rivera Olvera Jesús Noé , Estrada-Guel Ivanovich , Botello Villa Fabián
Published: December 2017

Mechanical ball milling assisted by sintering in the solid state was used in this research to produce the Zn-Nix system alloy. The derivative powder compositions of Zn-Nix (x = 0, 5, 10, 15, and 20 wt.%) were obtained to study the Ni effects on the microstructural and mechanical properties. It is worth remarking that conventional methods are not appropriate for the manufacture of the Zn-Nix system alloy. The morphological structure and phases were examined by optical microscopy, X-ray diffraction, and SEM/EDS elemental mapping, whereas the mechanical behavior was accomplished by means of a diamond indentation print (Hardness Vickers). The results showed that the intermetallic γ-ZnNi phase did not form during milling time (<4 h); it appears after the sintering process, which is associated with atomic diffusion mechanism through grain boundary at the minimum interfacial energy (ΔG256°C = −13.83 kJ·mol−1). The powder Zn-Ni10 was found to have better properties. Semispherical coarser particles were seen into the metal matrix (Zn δ-hcp structure) as segregates; however, each particle contains an intermetallic compound Zn-Ni that encloses the Ni (α-fcc structure) pure phase. The Ni-α phase was then transformed into a γ-ZnNi intermetallic compound which shifts to higher values of mechanical hardness from about 60 HV to 400 HV units.
State-of-the-Art Report on Fiber-Reinforced Lightweight Aggregate Concrete Masonry
Authors: Rico Saul , Farshidpour Roshanak , Tehrani Fariborz M.
Published: December 2017

Masonry construction is the most widely used building method in the world. Concrete masonry is relatively low in cost due to the vast availability of aggregates used within the production process. These aggregate materials are not always reliable for structural use. One of the principal issues associated with masonry is the brittleness of the unit. When subject to seismic loads, the brittleness of the masonry magnifies. In regions with high seismic activity and unspecified building codes or standards, masonry housing has developed into a death trap for countless individuals. A common approach concerning the issue associated with the brittle characteristic of masonry is addition of steel reinforcement. However, this can be expensive, highly dependent on skillfulness of labor, and particularly dependent on the quality of available steel. A proposed solution presented in this investigation consists of introducing steel fibers to the lightweight aggregate concrete masonry mix. Previous investigations in the field of lightweight aggregate fiber-reinforced concrete have shown an increase in flexural strength, toughness, and ductility. The outcome of this research project provides invaluable data for the production of a ductile masonry unit capable of withstanding seismic loads for prolonged periods.
Immunotherapy for Metastatic Melanoma with Right Atrial Involvement in a Patient with Rheumatoid Arthritis
Authors: Benson Zachary , Gordon Sarah , Nicolato Patricia , Poklepovic Andrew
Published: December 2017

Prognosis for metastatic melanoma has improved significantly with the use of immune checkpoint inhibitors. Given improvements in survival, aggressive surgical treatment may be considered in patients with life-threatening complications from their disease that would not otherwise be considered in advanced disease. Patients with preexisting autoimmune diseases or prior immune-related adverse events from therapy are largely excluded from clinical trials. Concerns exist that immunotherapy in these patients could worsen autoimmune disease or increase the risk of developing additional immune-related adverse events on therapy. We present a case of a patient with rheumatoid arthritis that presented with obstructive heart failure secondary to melanoma that had metastasized to the right atrium. After aggressive surgical resection to stabilize him from his life-threatening heart failure, he was treated with ipilimumab, which was stopped due to an immune-related adverse event. He was then started on pembrolizumab and had a durable response to therapy. Aggressive surgical treatment should be considered in patients with a cancer that may respond to immunotherapy. Furthermore, some patients with preexisting autoimmune disease may be safely treated with checkpoint inhibition therapy, and patients with a severe immune toxicity from one class may successfully be treated with an alternate class.
A New Method for the Determination of Sucrose Concentration in a Pure and Impure System: Spectrophotometric Method
Authors: Borji A. , Borji Fz. , Jourani A.
Published: December 2017

Analytical chemistry is a set of procedures and techniques used to identify and quantify the composition of a sample of material. It is also focused on improvements in experimental design and the creation of new measurement tools. Analytical chemistry has broad applications to forensics, medicine, science, and engineering. The objective of this study is to develop a new method of sucrose dosage using a spectrophotometry method in a pure and impure system (presence of glucose and fructose). The work performed shows the reliability of this method. A model linking sucrose solution absorbance and mass percentage of glucose and fructose has been developed using experimental design. The results obtained show that all the investigated factors (sucrose concentration, mass percentage of glucose, and mass percentage of fructose) have a positive effect on the absorbance. The effect of the interaction between glucose and fructose on the absorbance is very significant.
Impact of the Polymorphismrs9264942near theHLA-CGene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy
Authors: Herráiz-Nicuesa Laura , Hernández-Flórez Diana Carolina , Valor Lara , García-Consuegra Sonia , Navarro-Valdivieso Juan Paulo , Fernández-Cruz Eduardo , Rodríguez-Sainz Carmen
Published: December 2017

Several genome-wide association studies have identified a polymorphism located 35 kb upstream of the coding region ofHLA-Cgene (rs9264942; termed −35 C/T) as a host factor significantly associated with the control of HIV-1 viremia in untreated patients. The potential association of this host genetic polymorphism with the viral reservoirs has never been investigated, nor the association with the viral control in response to the treatment. In this study, we assess the influence of the polymorphism −35 C/T on the outcome of virus burden in 183 antiretroviral-naïve HIV-1-infected individuals who initiated antiviral treatment (study STIR-2102), analyzing HIV-1 RNA viremia and HIV-1 DNA reservoirs. Thers9264942genotyping was investigated retrospectively, and plasma levels of HIV-1 RNA and peripheral blood mononuclear cell- (PBMC-) associated HIV-1 DNA were compared between carriers and noncarriers of the protective allele −35 C before antiretroviral therapy (ART), one month after ART and at the end of the study (36 months). HIV-1 RNA and HIV-1 DNA levels were both variables significantly different between carriers and noncarriers of the allele −35 C before ART. HIV-1 DNA levels remained also significantly different one month posttherapy.However, this protective effect of the −35 C allele was not maintained after long-term ART.
S. lugdunensisNative-Joint Septic Arthritis: Case Report and Review of the Literature
Authors: Tan C. Danielle , Moritz Donna , Mena Lora Alfredo J.
Published: December 2017

Staphylococcus lugdunensisis a skin commensal classified as a coagulase-negativeStaphylococcus(CoNS). Though CoNS is typically associated with less aggressive clinical disease thanStaphylococcus aureus, there is growing awareness thatS. lugdunensismay be as virulent asS. aureus. The association betweenS. lugdunensisand infective endocarditis is well known, but few reports of native-joint disease with this organism exist. We report a case a 28-year-old male with no prior medical problems presenting with native-joint septic arthritis. Cultures grewS. lugdunensis. To our knowledge, this is the fifth case reported in the literature.
Reliable Collaborative Filtering on Spatio-Temporal Privacy Data
Authors: Liu Zhen , Meng Huanyu , Ren Shuang , Liu Feng
Published: December 2017

Lots of multilayer information, such as the spatio-temporal privacy check-in data, is accumulated in the location-based social network (LBSN). When using the collaborative filtering algorithm for LBSN location recommendation, one of the core issues is how to improve recommendation performance by combining the traditional algorithm with the multilayer information. The existing approaches of collaborative filtering use only the sparse user-item rating matrix. It entails high computational complexity and inaccurate results. A novel collaborative filtering-based location recommendation algorithm called LGP-CF, which takes spatio-temporal privacy information into account, is proposed in this paper. By mining the users check-in behavior pattern, the dataset is segmented semantically to reduce the data size that needs to be computed. Then the clustering algorithm is used to obtain and narrow the set of similar users. User-location bipartite graph is modeled using the filtered similar user set. Then LGP-CF can quickly locate the location and trajectory of users through message propagation and aggregation over the graph. Through calculating users similarity by spatio-temporal privacy data on the graph, we can finally calculate the rating of recommendable locations. Experiments results on the physical clusters indicate that compared with the existing algorithms, the proposed LGP-CF algorithm can make recommendations more accurately.
Telomeric G-Quadruplexes: From Human to Tetrahymena Repeats
Authors: Demkovičová Erika , Bauer Ľuboš , Krafčíková Petra , Tlučková Katarína , Tóthova Petra , Halaganová Andrea , Valušová Eva , Víglaský Viktor
Published: December 2017

The human telomeric and protozoal telomeric sequences differ only in one purine base in their repeats; TTAGGG in telomeric sequences; and TTGGGG in protozoal sequences. In this study, the relationship between G-quadruplexes formed from these repeats and their derivatives is analyzed and compared. The human telomeric DNA sequence G3(T2AG3)3 and related sequences in which each adenine base has been systematically replaced by a guanine were investigated; the result is Tetrahymena repeats. The substitution does not affect the formation of G-quadruplexes but may cause differences in topology. The results also show that the stability of the substituted derivatives increased in sequences with greater number of substitutions. In addition, most of the sequences containing imperfections in repeats which were analyzed in this study also occur in human and Tetrahymena genomes. Generally, the presence of G-quadruplex structures in any organism is a source of limitations during the life cycle. Therefore, a fuller understanding of the influence of base substitution on the structural variability of G-quadruplexes would be of considerable scientific value.
Detection and Molecular Characterization of Human Adenovirus Infections among Hospitalized Children with Acute Diarrhea in Shanghai, China, 2006–2011
Authors: Lu Lijuan , Zhong Huaqing , Su Liyun , Cao Lingfeng , Xu Menghua , Dong Niuniu , Xu Jin
Published: December 2017

Background: Human adenovirus (HAdV) is considered a significant enteropathogen associated with sporadic diarrhea in children. However, limited data are available regarding the epidemiology of HAdV in hospitalized children with viral diarrhea in Shanghai. The aim of this study was to characterize the epidemiology of HAdVs and describe their association with acute diarrhea in hospitalized children.Methods: A total of 674 fecal samples were subjected to PCR or RT-PCR to detect RVA, HuCV, HAstV, and HAdV.Results: HAdV infections were detected in 4.7% (32/674) of specimens, with detection rates of 13.4% (11/82), 4.6% (8/174), 3.2% (4/124), 4.1% (3/74), 2.0% (2/100), and 3.3% (4/120) from 2006 to 2011, respectively. Comprehensive detection of the four viruses revealed the presence of a high percentage (90.6%) of coinfections among HAdV-positive samples, where HAdV+RVA was the most prevalent coinfection. Of the 32 HAdV-positive samples, 50.0% (16/32) were classified as HAdV-41, and 18.8% (6/32) were classified as HAdV-3. Almost 94.0% of children infected with HAdV were less than 24 months of age.Conclusions: These results clearly indicated diversity across the HAdV genotypes detected in inpatient children with acute diarrhea in Shanghai and suggested that HAdVs play a role in children with acute diarrhea.
RhizosphericBacillus subtilisExhibits Biocontrol Effect againstRhizoctonia solaniin Pepper(Capsicum annuum)
Authors: Huang Yuanyuan , Wu Zhansheng , He Yanhui , Ye Bang-Ce , Li Chun
Published: December 2017

This study aimed at evaluating the ability of SL-44 to controlRhizoctonia solaniand promote pepper(Capsicum annuum)growth. Strain SL-44 was isolated from plant rhizosphere and the pot experiment results indicated that the dry and fresh weights of pepper in SL-44 andRhizoctonia solani(S-R) treatment were 45.5% and 54.2% higher than those inRhizoctonia solani(R) treatment and 18.2% and 31.8% higher than those in CK (control, noninoculation) treatment. The plant height in S-R treatment increased by 14.2% and 9.0% compared with those in the R and CK treatments, respectively. In vitro antagonism assay showed that SL-44 exhibited strong antifungal activity against the mycelial growth ofRhizoctonia solani, with an inhibition rate of 42.3%. The amount of phosphorus dissolved by SL-44 reached 60.58 mg·L−1in broth and 7.5 μg·mL−1IAA were secreted by SL-44. Strain SL-44 inhibited the growth ofR. solaniand improved biomass of pepper plants. Mass exchange and information transmission between the pepper plants and SL-44 mutually promoted their development.Bacillus subtilisSL-44 has a great potential as biocontrol agent againstRhizoctonia solanion pepper plants.
Impact of Chestnut and Quebracho Tannins on Rumen Microbiota of Bovines
Authors: Díaz Carrasco Juan María , Cabral Claudio , Redondo Leandro Martín , Pin Viso Natalia Daniela , Colombatto Darío , Farber Marisa Diana , Fernández Miyakawa Mariano Enrique
Published: December 2017

The use of phytogenic dietary additives is being evaluated as a means to improve animal productivity. The effect of tannins seems to be the influence not only directly on the digestive process through binding of dietary proteins but also indirectly over their effects on gastrointestinal microbiota. High-throughput sequencing of 16S rRNA gene was used to analyze the impact of dietary supplementation with a blend of chestnut and quebracho tannins on the rumen microbiota of Holstein steers. Bacterial richness was lower in tannins treated animals, while the overall population structure of rumen microbiota was not significantly disturbed by tannins. The ratio of the phyla Firmicutes and Bacteroidetes, a parameter associated with energy harvesting function, was increased in tannins supplemented animals, essentially due to the selective growth of Ruminococcaceae over members of genusPrevotella. Fibrolytic, amylolytic, and ureolytic bacterial communities in the rumen were altered by tannins, while methanogenic archaea were reduced. Furthermore, ruminal pH was significantly higher in animals supplemented with tannins than in the control group, while urease activity exhibited the opposite pattern. Further work is necessary to assess the relation between tannins impact on rumen microbiota and alteration of rumen fermentation parameters associated with bovine performance.