bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy and Toxicity of Different Concurrent Chemoradiotherapy Regimens in Patients With Locally Advanced Non-Small Cell Lung Cancer-a Network Meta-Analysis­
Authors: Zheng Qiang-qiang , Min Shi-hui , Zhou Qing-hua
Published: May 2021

Background: Concurrent chemoradiotherapy (CCRT) is the cornerstone treatment for patients with locally advanced non-small cell lung cancer (LA-NSCLC). The aim of this study was to compare the efficacy and toxicity of different CCRT regimens in the treatment of LA-NSCLC by adopting a network meta-analysis.Methods: PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (CENTRAL) were exhaustively searched to identify relevant studies from inception up to October 1, 2020. Direct and indirect evidence were combined to calculate the odds radio (OR) and its 95% confidence interval (CI), as well as to draw the surface under the cumulative ranking (SUCRA) curves. Cluster analyses were adopted to compare efficacy and toxicity of different CCRT regimens according to the similarity of 2 variables. Publication bias was detected by comparison-adjusted funnel plot.Results: Twenty-two studies were enrolled in this network meta-analysis, including 18 CCRT regimens: CCRT (cisplatin+etoposide), CCRT (carboplatin+paclitaxel), CCRT (pemetrexed+carboplatin), CCRT (pemetrexed+cisplatin), CCRT (docetaxel+cisplatin), CCRT (S-1+cisplatin), CCRT (mitomycin+vindesine+cisplatin), CCRT (cisplatin+vinorelbine), CCRT (cisplatin), CCRT (etoposide+cisplatin+amifostine), RT, CCRT (5-FU), CCRT (paclitaxel+cisplatin), CCRT (irinotecan+carboplatin), CCRT (nedaplatin), CCRT (carboplatin+etoposide), CCRT (paclitaxel), and CCRT (carboplatin). The results indicated that the regimens with CCRT (cisplatin+etoposide), CCRT (carboplatin+paclitaxel), CCRT (pemetrexed+cisplatin), CCRT (S-1+cisplatin), and CCRT (cisplatin+vinorelbine) had relatively better efficacy compared with other regimens. As for toxicity of different CCRT regimens, the CCRT (carboplatin+paclitaxel), CCRT (pemetrexed+cisplatin), and CCRT (docetaxel+cisplatin) were relatively lower.Conclusions: Our study demonstrated that CCRT (pemetrexed+cisplatin) and CCRT (carboplatin+paclitaxel) might be the best choice of CCRT regimens in the treatment of LA-NSCLC, and the 3-year overall survival (OS) rate of CCRT (pemetrexed+cisplatin) was the highest among these regimens.
Essential Dynamics for Developing Models for Control of Connected and Automated Electrified Vehicles: Part A - Powertrain
Authors: Hemmati Sadra , yadav Rajeshwar , Surresh Kaushik , Robinette Darrell , Shahbakhti Mahdi
Published: May 2021

Connected and Automated Vehicles (CAV) technology presents significant opportunities for energy saving in the transportation sector. CAV technology forecasts vehicle and powertrain power needs under various terrain, ambient, and traffic conditions. Even though the CAV technology is applicable to both conventional and electrified powertrains, the energy saving opportunities are more apparent when the CAVs are Hybrid Electric Vehicles (HEVs). This is because of the flexibility in the vehicle powertrain and possibility of choosing optimum powertrain modes based on the predicted traction power needs. In this paper, the powertrain dynamics essential for developing powertrain controllers for a class of connected HEVs is presented. To this end, control-oriented powertrain dynamic models for a test vehicle consisting of full electric, hybrid, and conventional engine operating modes are developed. The resulting powertrain model can forecast vehicle traction torque and energy consumption for the specified prediction horizon of the test vehicle. The model considers different operating modes and associated energy penalty terms for mode switching. Thus, the vehicle controller can determine the optimum powertrain mode, torque, and speed for forecasted vehicle operation via utilizing connectivity data. The powertrain model is validated against the experimental data and shows prediction error of less than 5% for predicting vehicle energy consumption.
Translation of a circulating melanoma microRNA profile into a solid tissue assay to improve diagnostic accuracy
Authors: Laar Ryan Van , King Samuel , McCoy Richard , Saad Mirette , Fereday Sian , Winship Ingrid , Uzzell Catherine , Landgren Anthony
Published: May 2021

Background: Successful treatment of cutaneous melanoma depends on early and accurate diagnosis of clinically suspicious melanocytic skin lesions. Multiple international studies have described the challenge of providing accurate and reproducible histopathological assessments of melanocytic lesions, highlighting the need for new diagnostic tools including disease-specific biomarkers. Previously, a 38-microRNA signature (“Mel38”) was identified in melanoma patient plasma and validated as a novel biomarker. In this study, Mel38 expression in solid tissue biopsies representing the benign naevi to metastatic melanoma spectrum is examined. Methods: Nanostring digital gene expression assessment of the Mel38 signature was performed on 308 formalin fixed paraffin embedded biopsies of naevi, melanoma in-situ and invasive melanoma. Genomic data were interrogated using hierarchical clustering, univariate, and multivariate statistical approaches. Classification scores computed from the Mel38 signature were analysed for their association with demographic data and histopathology results, including MPATH-DX class, AJCC disease stage and tissue subtype. Results: The Mel38 score can stratify higher-risk melanomas (MPATH-Dx Class V or more advanced) from lower-risk skin lesions (Class I-IV) with an area-under-the curve of 0.96 (P<0.001). The genomic score ranges from 0 to 10 and is positively correlated with melanoma progression, with an intraclass correlation coefficient of 0.85 with stage 0 to IV disease. Using an optimised classification threshold of ≥2.3 accurately identifies higher-risk melanomas, associated with poorer outcomes and more intensive suggested clinical actions with 95% sensitivity and 83% specificity. Multivariate analysis showed the score to be a significant predictor of malignancy, independent of technical and clinical covariates. Application of the Mel38 signature to spitz naevi reveal an intra-subtype profile, with elements of the profile in common to both naevi and melanoma. Conclusion: Melanoma-specific circulating microRNAs maintain their association with malignancy when measured in the hypothesized tissue of origin. The Mel38 signature is an accurate and reproducible metric of melanoma status, based on changes in microRNA expression that occur as the disease develops and spreads. Inclusion of the Mel38 score into routine practice would provide physicians with previously unavailable, personalised genomic information about their patient’s skin lesions. Combining molecular biomarker data with conventional histopathology data may improve diagnostic accuracy, healthcare resource utilisation, and patient outcomes.
HEA BeadChip™ technology in immunohematology
Authors: Paccapelo C. , Truglio F. , Villa M.A. , Revelli N. , Marconi M.
Published: May 2021

Classic methods to determine human red blood cell (RBC) antigens are based on serologic testing. Thanks to increased knowledge of the molecular basis associated with many blood group antigens, it is currently possible to predict their presence or absence on the red cell membrane. Several molecular techniques have been developed to detect the most important allelic variations attributable to single nucleotide polymorphisms. The human erythrocyte antigen (HEA) BeadChip™ system manufactured by BioArray Solutions (Immucor, Warren, NJ) is one of the commercial DNA array platforms currently available to predict HEAs by DNA analysis. This technology provides a useful tool to increase the inventory of antigen-negative RBC units and prevent immunization of patients who require chronic transfusion by providing compatible RBC units based on matching by DNA testing.
Immunohematology

2015;31:81–90.
Drug-induced immune thrombocytopenia: incidence, clinical features, laboratory testing, and pathogenic mechanisms
Authors: Curtis B.R.
Published: May 2021

Drug-induced immune thrombocytopenia (DIIT) is a relatively uncommon adverse reaction caused by drug-dependent antibodies (DDAbs) that react with platelet membrane glycoproteins only when the implicated drug is present. Although more than 100 drugs have been associated with causing DIIT, recent reviews of available data show that carbamazepine, eptifibatide, ibuprofen, quinidine, quinine, oxaliplatin, rifampin, sulfamethoxazole, trimethoprim, and vancomycin are probably the most frequently implicated. Patients with DIIT typically present with petechiae, bruising, and epistaxis caused by an acute, severe drop in platelet count (often to <20,000 platelets/µL). Diagnosis of DIIT is complicated by its similarity to other non–drug-induced immune thrombocytopenias, including autoimmune thrombocytopenia, posttransfusion purpura, and platelet transfusion refractoriness, and must be differentiated by temporal association of exposure to a candidate drug with an acute, severe drop in platelet count. Treatment consists of immediate withdrawal of the implicated drug. Criteria for strong evidence of DIIT include (1) exposure to candidate drug–preceded thrombocytopenia; (2) sustained normal platelet levels after discontinuing candidate drug; (3) candidate drug was only drug used before onset of thrombocytopenia or other drugs were continued or reintroduced after resolution of thrombocytopenia, and other causes for thrombocytopenia were excluded; and (4) reexposure to the candidate drug resulted in recurrent thrombocytopenia. Flow cytometry testing for DDAbs can be useful in confirmation of a clinical diagnosis, and monoclonal antibody enzyme-linked immunosorbent assay testing can be used to determine the platelet glycoprotein target(s), usually GPIIb/IIIa or GPIb/IX/V, but testing is not widely available. Several pathogenic mechanisms for DIIT have been proposed, including hapten, autoantibody, neoepitope, drug-specific, and quinine-type drug mechanisms. A recent proposal suggests weakly reactive platelet autoantibodies that develop greatly increased affinity for platelet glycoprotein epitopes through bridging interactions facilitated by the drug is a possible mechanism for the formation and reactivity of quinine-type drug antibodies.
Immunohematology

2014;30:55–65.
Drugs that have been shown to cause drug-induced immune hemolytic anemia or positive direct antiglobulin tests: some interesting findings since 2007
Authors: Garratty G. , Arndt P.A.
Published: May 2021

This review updates new findings in drug-induced immune-hemolytic anemia (DIIHA) since the 2007 review in Immunohematology by these authors. Twelve additional drugs have been added to the three tables listing drugs associated with drug-dependent antibodies, drugs associated with drug-independent antibodies, and drugs associated with nonimmunologic protein adsorption. Other updated findings include (1) piperacillin is currently the most commonly encountered cause of DIIHA, (2) new data on blood group specificity of drug-dependent antibodies, (3) drug-dependent antibodies detected in healthy donors, (4) DIIHA associated with transplantation, and (5) DIIHA associated with chemotherapeutic drugs.
Immunohematology

2014;30:66–79.
Posttransplant maternal anti-D: a case study and review
Authors: Senzel L. , Avila C. , Ahmed T. , Gill H. , Hue-Roye K. , Lomas-Francis C. , Reid M.E.
Published: May 2021

Plasma from a 35-year-old, D– woman was found to have anti-D, -C, and -G at 5 weeks’ gestation and again at 8 weeks’ gestation, when she presented with a nonviable intrauterine pregnancy. The anti-D titer increased with a pattern that suggested it was stimulated by the 8-week pregnancy. Six years before this admission, the patient’s blood type changed from group O, D+ to group O, D– after a bone marrow transplant for aplastic anemia. Three years after transplant, the antibody screen was negative. After the patient was admitted for the nonviable pregnancy, the products of con-ception were found to be D+ by DNA testing for RHD. There were no documented transfusions or pregnancies during the interval in which anti-D appeared. The timing of the alloimmunization was unusual. In a subsequent pregnancy, fetal D typing was performed by molecular methods.
Immunohematology

2012;28:55–9.
Performance of an automated solid-phase red cell adherence system compared with that of a manual gel microcolumn assay for the identification of antibodies eluted from red blood cells
Authors: Finck R.H. , Davis R.J. , Teng S. , Goldfinger D. , Ziman A.F. , Lu Q. , Yuan S.
Published: May 2021

IgG antibodies coating red blood cells (RBCs) can be removed by elution procedures and their specificity determined by antibody identification studies. Although such testing is traditionally performed using the tube agglutination assay, prior studies have shown that the gel microcolumn (GMC) assay may also be used with comparable results. The purpose of this study was to compare an automated solid-phase red cell adherence (SPRCA) system with a GMC assay for the detection of antibodies eluted from RBCs. Acid eluates from 51 peripheral blood (PB) and 7 cord blood (CB) samples were evaluated by both an automated SPRCA instrument and a manual GMC assay. The concordance rate between the two systems for peripheral RBC samples was 88.2 percent (45 of 51), including cases with alloantibodies (n = 8), warm autoantibodies (n = 12), antibodies with no identifiable specificity (n = 2), and negative results (n = 23). There were six discordant cases, of which four had alloantibodies (including anti-Jka, -E, and -e) demonstrable by the SPRCA system only. In the remaining 2 cases, anti-Fya and antibodies with no identifiable specificity were demonstrable by the GMC assay only. All seven CB specimens produced concordant results, showing anti-A (n = 3), -B (n = 1), maternal anti-Jk a (n = 2), or a negative result (n = 1). Automated SPRCA technology has a performance that is comparable with that of a manual GMC assay for identifying antibodies eluted from PB and CB RBCs.
Immunohematology

2011;27:1–5.
Weak D type 42 cases found in individuals of European descent
Authors: St-Louis M. , Richard M. , Côté M. , Éthier C. , Long A.
Published: May 2021

Patient samples were referred to our immunohematology reference laboratory to investigate the presence of a weak D antigen. In the last 3 years, 26 samples were received. Serology and molecular analyses were performed to identify the weak D variant. RHD mRNA from all patients was reverse transcribed, and cDNA was sequenced. The results were compared with a normal RHD sequence to identify the polymorphisms causing the weak D phenotype. Five different already known RHD variants were observed: weak D type 1 (5 individuals), weak D type 2 (1 individual), weak D type 42 (17 individuals), weak D type 45 (1 individual), and partial D DNB (2 individuals). Surprisingly, weak D type 42 was prevalent in our population, whereas weak D type 1, 2, and 3 are the most prevalent variants elsewhere. Anti-D was found in six cases of weak D type 42. The higher prevalence of weak D type 42 could be the result of a founder effect. Additional studies are needed to estimate the frequency of this variant in the general population.
Immunohematology

2011;27:20–24.
Preoperative coagulation studies to predict blood component usage in coronary artery bypass graft surgery
Authors: Josefy S. , Briones R. , Bryant B.J.
Published: May 2021

Bleeding remains a serious complication of cardiac surgery. Studies indicate that preoperative fibrinogen concentration is an independent predictor of blood loss during coronary artery bypass graft (CABG) surgery. This study evaluates whether fibrinogen concentration is a better predictor of blood usage than the prothrombin time (PT) and activated partial thromboplastin time (aPTT) tests. Patients not taking clopidogrel bisulfate who underwent CABG surgery during a 3-month period at a 350-bed community hospital were included in this prospective study. The parameters evaluated included patient’s age, preoperative coagulation test results (PT, international normalized ratio [INR], aPTT, fibrinogen), and number of blood components transfused. A probability value of less than 0.05 was deemed significant. Thirty-five patients were included in this study. Mean blood usage was 6 units. Patient’s age approached significance as a predictor of blood usage, and fibrinogen levels trended toward significance more than the other coagulation parameters. In this study, the increased age of the patient and low plasma concentrations of fibrinogen were associated with increased blood usage. Although no indicators clearly demonstrated statistical significance, the vast difference in the probability values for patients’ ages and fibrinogen levels indicated that there was a trend toward significance in blood usage for CABG patients. Further studies with larger patient populations are indicated.
Immunohematology

2011;27:151–153.
Granulocyte serology: current concepts and clinical signifcance
Authors: Clay M.E. , Schuller R.M. , Bachowski G.J.
Published: May 2021

Applying serologic procedures to the detection of RBC and lymphocyte antigens has facilitated the identification of granulocyte antigens with established clinical significance, which are now classified in the human neutrophil antigen system. Granulocyte alloantibodies and autoantibodies have been implicated in a variety of clinical conditions including alloimmune neutropenia, autoimmune neutropenia, febrile and severe pulmonary transfusion reactions, drug-induced neutropenia, refractoriness to granulocyte transfusions, and immune neutropenia after hematopoietic stem cell transplantation. Although the intrinsically fragile nature of granulocytes contributes to the inherent challenges of granulocyte serology, several advances in laboratory procedures have improved detection of granulocyte antibodies. This review will provide a current perspective about the importance and use of granulocyte serology for detection of granulocyte antibodies that have significant medical effects.
Immunohematology

2010;26:11–21.
The Duffy blood group system: a review
Authors: Meny G.M.
Published: May 2021

Duffy was the fi rst blood group mapped to an autosome (chromosome 1) using cytogenetic studies. Duffy antigens are located on a glycoprotein that can be found on erythrocytes and other cells throughout the body. Fya and Fyb are products of their respective alleles (FY*A, FY*B ). Fyx, characterized by weak Fyb expression, is a result of an additional mutation in FY*B. The Fy(a–b–) phenotype, most commonly found in Blacks, occurs primarily as a result of a GATA promoter region mutation upstream of the FY allele. This mutation prevents expression of Duffy glycoprotein on erythrocytes only, while permitting expression on nonerythroid cells. Other antigens include Fy3, Fy5, and Fy6. Antibodies to Duffy antigens are usually clinically signifi cant and have been reported to cause hemolytic disease of the fetus and newborn. This review provides a general overview of the Duffy blood group system, including the role of the Duffy glycoprotein as a chemokine receptor (Duffy antigen receptor for chemokines) and in malarial infection.
Immunohematology 2010;26:51–56.
The Gerbich blood group system: a review
Authors: Walker P.S. , Reid M.E.
Published: May 2021

Antigens in the Gerbich blood group system are expressed on glycophorin C (GPC) and glycophorin D (GPD), which are both encoded by a single gene, GYPC. The GYPC gene is located on the long arm of chromosome 2, and Gerbich antigens are inherited as autosomal dominant traits. There are 11 antigens in the Gerbich blood group system, six of high prevalence (Ge2, Ge3, Ge4, GEPL [Ge10*], GEAT [Ge11*], GETI [Ge12*]) and five of low prevalence (Wb [Ge5], Lsa [Ge6], Ana [Ge7], Dha [Ge8], GEIS [Ge9]). GPC and GPD interact with protein 4.1R, contributing stability to the RBC membrane. Reduced levels of GPC and GPD are associated with hereditary elliptocytosis, and Gerbich antigens act as receptors for the malarial parasite Plasmodium falciparum. Anti-Ge2 and anti-Ge3 have caused hemolytic transfusion reactions, and anti-Ge3 has produced hemolytic disease of the fetus and newborn (HDFN).
Immunohematology

2010;26:60–65.
Allogeneic adsorptions: a comparison of the traditional method with a modified PEG adsorption method
Authors: Etem M.E. , Laird-Fryer B. , Holub M.P. , Hedl J.J. , Symington D.B. , Figueroa D.
Published: May 2021

The purpose of this study is to demonstrate the benefits of enhancing adsorptions with PEG. Allogeneic adsorptions were performed on 20 patient samples containing warm reactive autoantibodies with two volumes of adsorbing RBCs; results using unenhanced adsorptions were compared with those using PEG-enhanced adsorptions and with using untreated adsorbing RBCs and ficin-treated adsorbing RBCs. Two volumes of adsorbing RBCs, one volume of serum, and one volume of PEG were used. The number of adsorptions, average time saved, and presence or absence of underlying alloantibodies were compared for the two methods and types of adsorbing RBCs. Modified PEG-enhanced adsorptions resulted in a 69 percent decrease in adsorbing time. PEG adsorptions removed all autoantibodies and detected 18 of 19 underlying alloantibodies. The unenhanced method did not remove autoantibodies in two samples and identified only 15 of 19 underlying alloantibodies. As expected, reductions in the number of adsorptions and adsorbing time were observed. The modified-PEG adsorption is an improved method that may replace the current unenhanced method.
Immunohematology

2010;26:104–108.
‘When you preach water and you drink wine’: WASH in healthcare facilities in Kenya
Authors: Abu Thelma Zulfawu , Elliott Susan J. , Karanja Diana
Published: May 2021

Access to basic water, sanitation and hygiene, waste management and environment cleaning (WASH) in healthcare facilities (HCFs) is critical for infection prevention and control. The WHO/UNICEF 2019 global baseline report on WASH in HCFs indicates that 51 and 23% of those in sub-Saharan Africa have basic access to water and sanitation, respectively. Guided by the political ecology of health theory, this research engaged with 13 key informants, 16 healthcare workers and 31 community members on their experiences on the implementation, use and management of WASH in HCFs. Interviews were conducted in one informal settlement and three rural dispensaries in Kisumu, Kenya from May to September 2019. Findings indicate improvement in water access, yet water quality and other WASH service components remain a challenge even in newly constructed maternity facilities, thus impacting local health promotion efforts. Institutional challenges such as limited financial resources and ecological factors like climate variability and disease outbreaks compromised WASH infrastructure and HCF resilience. To achieve Sustainable Development Goal 3, good health and well-being, as well as Sustainable Development Goal 6, clean water and sanitation, the prioritisation of WASH in HCFs is required at all levels, from the local to the global.
Sources and routes from terrestrial exogenous pollutants affect phytoplankton biomass in reservoir bays
Authors: Hu R. Y.
Published: May 2021

Reservoir bays, at the terrestrial and water boundary, where water fluidity slows down and self-purification ability turns weak, hence they are especially sensitive to terrestrial exogenous pollutants, even resulting in eutrophication. According to N:P, water nutrient types can be divided into N limited, P limited and N + P limited classes. Phytoplankton biomass is represented by chlorophyll a, which is one of the sensitive indicators of water eutrophication. Comprehensively tracing non-point pollution from terrestrial exogenous pollutants (fertilizer, soil release, anthropogenic discharge) to water nutrients that happen in reservoir bays is of great significance. This paper identified the dominant environmental variables and nutrients' limited types of reservoir bays at storage and discharge periods, and constructed a partial least squares structural equation model (PLS-SEM) to explore the impacts of terrestrial exogenous pollutants. Results showed that in the storage period, water contamination mainly came from residential discharge and soil endogenous release, and the total contribution rate reached 61%. In the discharge period, with the increase of rainfall–runoff erosion, the explanatory ability of land use, topography and landscape pattern to water quality increased, up to 58%. The dominant nutrient limited types of reservoir bays were P limited (35%–47%) and N + P limited (35%–59%) at both stages, N limited situations were less than 20% and generally appeared in the storage period. Whatever the nutrient limited type was, phosphorus always had a higher effect on phytoplankton biomass. In the N limited situation, nitrogen came mainly from soil release (total effect = 0.6) and phosphorus from fertilizer (total effect = 0.22) and soil release (total effect = 0.17). In the P limited situation, all three sources had almost high effects on nitrogen, phosphorus, and phytoplankton biomass. In the N + P limited situation, anthropogenic discharge was the main source of nutrients and the primary threat factor for phytoplankton biomass. The approaches employed in this study could be generalized to other basins and the results were significant for early warning and controlling water eutrophication.
EEMD- and VMD-based hybrid GPR models for river streamflow point and interval predictions
Authors: Ghasempour Roghayeh , Azamathulla Hazi Mohammad , Roushangar Kiyoumars
Published: May 2021

Reliable river streamflow (RSF) forecasting is an important issue due to its impact on planning and operation of the water resources system. In this study, based on Lower Upper Bound Estimation (LUBE), hybrid artificial intelligence methods were used for point and interval prediction of monthly RSF. Two states based on stations' own data and upstream stations' data were considered for RSF modeling of the Housatonic River during the period of 1941–2018. Ensemble Empirical Mode Decomposition (EEMD) and Variational Mode Decomposition (VMD) methods were used for enhancing the streamflow point forecasting accuracy. Interval Prediction (PI) was applied for tolerating increased uncertainty. Results showed that in state 1, the error criterion value for the superior model decreased from 0.155 to 0.082 and 0.09 for the EEMD- and VMD-based models, respectively. Generally, hybrid models increased the modeling accuracy between 20% and 40%. Via the integrated approaches, the upstream stations' data was successfully used for streamflow prediction of stations without data. In this state, the PI coverage probability values for the VMD-based model were approximately 12% higher than the single model. Generally, the VMD-based model led to more desirable results due to having higher PI coverage probability and lower mean PI width values.
Pharmacological and Non-pharmacological Treatments of Sleep Disorders in Parkinson's Disease
Authors: Taximaimaiti Reyisha , Luo Xingguang , Wang Xiao-Ping
Published: May 2021

Sleep disorders are one of the most common non-motor symptoms in Parkinson's disease
(PD). It can cause a notable decrease in quality of life and functioning in PD patients, as well as
place a huge burden on both patients and caregivers. The most cited sleep disorders in PD included
insomnia, restless legs syndrome (RLS), rapid eye movement (REM), sleep behavior disorders
(RBD), excessive daytime sleepiness (EDS) and sleep disordered breathing (SDB), which can appear
alone or several at the same time. In this review, we listed the recommended pharmacological
treatments for common sleep disorders in PD, and discussed the recommended dosages, benefits
and side effects of relative drugs. We also discussed non-pharmacological treatments to improve
sleep quality, including sleep hygiene education, exercise, deep brain stimulation, cognitive behavior
therapy and complementary therapies. We tried to find proper interventions for different types of
sleep disorders in PD, while minimizing relative side effects.
Quantifying the Fleet Composition at Full Adoption of Shared Autonomous Electric Vehicles: An Agent-based Approach
Authors: Hogeveen Peter , Steinbuch Maarten , Verbong Geert , Hoekstra Auke
Published: May 2021

Aims:

Exploring the impact of full adoption of fit-for-demand shared and autonomous electric vehicles on the passenger vehicle fleet of a society.

Background:

Shared Eutonomous Electric Vehicles (SAEVs) are expected to have a disruptive impact on the mobility sector. Reduced cost for mobility and increased accessibility will induce new mobility demand and the vehicles that provide it will be fit-for-demand vehicles. Both these aspects have been qualitatively covered in recent research, but there have not yet been attempts to quantify fleet compositions in scenarios where passenger transport is dominated by fit-for-demand, one-person autonomous vehicles.

Objective:

To quantify the composition of the future vehicle fleet when all passenger vehicles are autonomous, shared and fit-for-demand and where cheap and accessible mobility has significantly increased the mobility demand.

Methods:

An agent-based model is developed to model detailed travel dynamics of a large population. Numerical data is used to mimic actual driving motions in the Netherlands. Next, passenger vehicle trips are changed to trips with fit-for-demand vehicles, and new mobility demand is added in the form of longer tips, more frequent trips, modal shifts from public transport, redistribution of shared vehicles, and new user groups. Two scenarios are defined for the induced mobility demand from SAEVs, one scenario with limited increased mobility demand, and one scenario with more than double the current mobility demand. Three categories of fit-for-demand vehicles are stochastically mapped to all vehicle trips based on each trip's characteristics. The vehicle categories contain two one-person vehicle types and one multi-person vehicle type.

Results:

The simulations show that at full adoption of SAEVs, the maximum daily number of passenger vehicles on the road increases by 60% to 180%. However, the total fleet size could shrink by up to 90% if the increase in mobility demand is limited. An 80% reduction in fleet size is possible at more than doubling the current mobility demand. Additionally, about three-quarters of the SAEVs can be small one-person vehicles.

Conclusion:

Full adoption of fit-for-demand SAEVs is expected to induce new mobility demand. However, the results of this research indicate that there would be 80% to 90% less vehicles required in such a situation, and the vast majority would be one-person vehicles. Such vehicles are less resource-intense and, because of their size and electric drivetrains, are significantly more energy-efficient than the average current-day vehicle. This research indicates the massive potential of SAEVs to lower both the cost and the environmental impact of the mobility sector. Quantification of these environmental benefits and reduced mobility costs are proposed for further research.
Analisis Pengaruh Panjang dan Bentuk Fiber Kaleng Bekas Terhadap Kuat Lentur dan Lebar Retak Balok Beton Bertulang
Authors:   Universitas Brawijaya, Wijatmiko Indradi , Wibowo Ari ,   Universitas Brawijaya, Nainggolan Christin Remayanti ,   Universitas Brawijaya
Published: May 2021

Pemanfaatan limbah sebagai material konstruksi merupakan salah satu inovasi dan solusi untuk mengurangi limbah. Pemanfaatan material limbah tersebut tidak hanya untuk mengtasi limbah tetapi juga untuk menghasilkan material konstruksi yang kuat dan bersifat green building. Salah satu limbah yang dapat dimanfaatkan dan banyak ditemukan di lingkungan sekitar adalah kaleng kemasan baik untuk minuman maupun makanan. Kaleng bekas kemasan merupakan material yang dapat didaur ulang dan dimanfaatkan kembali. Dengan menemukan manfaat lain dari kaleng bekas tentu akan meningkatkan nilai ekonomi dan fungsi dari kaleng bekas sehingga masyarakat dapat melihat sisi dan nilai lain dari kaleng bekas. Kaleng bekas yang telah dipotong-potong sehingga menyerupai serat/fiber dapat menjadi material fiber pada beton bertulang. Pada penelitian ini kaleng bekas dipotong sehingga dimensi nya menjadi 2 x 40 mm (polos dan pilin) dan 2 x 80 mm (polos). Fiber tersebut ditambahkan sebanyak 10% dari volume benda uji dan kemudian dilakukan uji lentur dan pengamatan lebar retak. Beton fiber memiliki kelemahan yaitu lemahnya ikatan antara fiber dengan semen sehingga dilakukan penelitian mengenai pengaruh panjang dan bentuk fiber kaleng bekas terhadap kuat lentur dan lebar retak beton betulang. Variasi fiber 80 mm polos memiliki bidang geser yang lebih luas daripada variasi lainnya sehingga memiliki ikatan fiber semen yang lebih baik dan dapat meningkatkan kuat lentur dan mengurangi retakan yang terjadi.
Using Iron Ore Waste As Aggregate in Making K.30 Quality Concrete
Authors:   Bandar Lampung University, Amin Muhammad ,   Mineral Technology Research of Indonesian Institute of Sciences – LIPI, Setiaji Harjianto ,   Sang Bumi Ruwa Jurai University
Published: May 2021

The main component of concrete is cement, water, and aggregate (fine and rough aggregate), with aggregate constituting between 50% and 60% of total volume. Iron stone coming from nature is a material alternative that can be used as rough aggregate in making concrete. This research was conducted by sieving iron ores with sieving particle sizes of 2mm, 2-5 mm, 5-8 mm, and 10-12 mm. The compressive strength test was conducted at 7, 14, and 28 days. The iron ore waste from iron processing can be used as aggregate for K 300 quality concrete because the concrete compressive test result after 28 days by using sieving particle sizes of mesh 20, mesh 5, mesh 8-10, and mesh 10-12 exceeded normal K 300 quality concrete with compressive strength scores of 30.12 MPa, 38.90 MPa, 36.75 MPa, and 32.10 Mpa respectively, while normal K 300 quality concrete had 28.86 MPa compressive strength.
Strategi Mitigasi Resiko Supply Chain Dengan Metode House of Risk
Authors:   Universitas Bojonegoro, Abryandoko Eko Wahyu , Mushthofa Mushthofa ,   Universitas Bojonegoro
Published: May 2021

CV. Asri Tehnika is a company engaged in the construction, one of the projects that is now in the work by CV. Asri Tehnika is a project building construction of SDN Tlogoagung in Bojonegoro district. This research aims to identify various risks that occur in CV. Asri Tehnika at the time of construction of the building of SDN Tlogoagung District Kedungadem District Bojonegoro, along with the cause. The method used in this research is House of Risk, this method consists of two phases, namely the first phase to identify risk and risk agent, while the second phase is risk management. This research is expected to assist in the problem of supply chain activities within the company.
Analisis Risiko Rantai Pasok Material Terhadap Keterlambatan Pelaksanaan Proyek Konstruksi
Authors:   Universitas Gunadarma, Kurniawan Hendi , Anggraeni Ida Ayu Ari ,   Universitas Gunadarma
Published: May 2021

The uncertainty of the supply chain in the process of procuring building materials can be a risk that results in delays in the implementation of construction projects. This study aims to analyze the material supply chain risks that affect delays in the implementation of construction projects. Supply chain risks are classified from Supply, Control, Demand, and Process. Data collection by survey method and respondents selected by purposive sampling method. The analysis used is the AHP method. The risk response is confirmed to the expert by the interview method. The results of the risk assessment found that the late delivery of material due to non-current financial problems with FR = 0.703 was the most risky factor resulting in project development delays.
Intervención en las problemáticas familiares, barrio la divisa, comuna 13 – Medellín
Authors: Vega Fajardo Jeniffer Ximena , Vargas Amézquita Sonia Lucía
Published: May 2021

Este estudio presenta la intervencio?n en los aspectos emocionales, socioculturales y cognitivos de las diferentes problema?ticas encontradas en las familias del Barrio la Divisa de la ciudad de Medelli?n bajo el enfoque de investigacio?n cualitativa, con disen?o investigacio?n, accio?n – participativa, dividida en tres fases: diagno?stico, planeacio?n - ejecucio?n, y evaluacio?n.

Se lograron disen?ar estrategias para atender cada una de las necesidades que se percibieron en la comunidad en la fase diagno?stica desde siete microproyectos y se realizo? la ejecucio?n de estos, llevando actividades semanales a 45 nin?os y sus familias quienes participaron libremente del proyecto. Para la tercera fase se espera realizar la evaluacio?n de impacto social de la intervencio?n realizada.

Palabras Clave: Intervencio?n social, familia, infancia.

Abstract

This study presents the intervention in the emotional, sociocultural and cognitive aspects of the different problems found in the families of the neighborhood la Divisa of the city of Medelli?n under the qualitative research approach, with research design, action - participatory, divided into three phases: diagnosis, planning - execution, and evaluation.

We managed to design strategies to address each of the needs that were perceived in the community in the diagnostic phase from seven microprojects and the execution of these was carried out, taking weekly activities to 45 children and their families who freely participated in the project. For the third phase, it is expected to carry out the social impact assessment of the intervention carried out.

Keywords: Social intervention, family, childhood.

Resumo

Este estudo apresenta a intervenc?a?o nos aspectos emocionais, socioculturais e cognitivos das diferentes problema?ticas encontradas nas fami?lias do Bairro La Divisa da cidade de Medelli?n sob o enfoque de investigac?a?o qualitativa, com desenho, investigac?a?o, ac?a?o participativa, dividida em tre?s fases: diagno?stico, planejamento –execuc?a?o e avaliac?a?o. Conseguiu-se desenhar estrate?gias para atender cada uma das necessidades que foram percebidas na comunidade na fase de diagno?stico desde sete microprojetos e sua posterior realizac?a?o, efetuando atividades semanais a 45 crianc?as e suas fami?lias que participaram livremente do projeto. Para a terceira fase, se espera realizar a avaliac?a?o do impacto social da intervenc?a?o realizada.

Palavras chave: Intervenc?a?o Social; Fami?lia; Infa?ncia.
Psicologi?a de la religio?n: reconocimiento teo?rico y panorama investigativo
Authors: Cano García Mariluz , Quintero Núñez Helmer
Published: May 2021

Resumen

En el argumento del presente arti?culo se ostentan algunas revisiones histo?ricas y descriptivas de la psicologi?a de la religio?n; se refieren y diferencian determinadas nociones como “psicologi?a de la religio?n”, “psicologi?a y religio?n”, y “psicologi?a religiosa”, se advierte de las modificaciones conceptuales de diferentes enfoques y corrientes afirmados en el a?rea, como el de naturaleza fenomenolo?gica; y se resen?an algunos estudios de la actualidad investigativa por continentes.

Palabras Clave: psicologi?a, religio?n, naturaleza fenomenolo?gica.

Abstract

In the argument of the present article there are some historical and descriptive reviews of the psychology of religion; they refer and differentiate certain notions such as "psychology of religion", "psychology and religion", and "religious psychology", warns of the conceptual modifications of different approaches and currents within the subdiscipline that are being affirmed, such as nature phenomenological; and some current research studies by continents are reviewed.

Keywords: psychology,religion,phenomenologicalnature.

Resumo

O argumento do presente artigo se fundamenta em algumas reviso?es histo?ricas e descritivas da psicologia da religia?o; se referem e diferenciam determinadas noc?o?es como “psicologia da religia?o”, “psicologia e religia?o”, e “psicologia religiosa”. Se adverte das modificac?o?es conceituais de diferentes enfoques e correntes afirmados na a?rea, como o de natureza fenomenolo?gica; e se resenham alguns estudos da atualidade por continentes.

PALAVRAS CHAVE: psicologia, religia?o, natureza fenomenolo?gica
Un acercamiento multidimensional al santuario del Éxodo como revelación de Dios
Authors: Anaya Raquel , Benigno Quintero Helmer , Barrero William
Published: May 2021

The sanctuary of Exodus is an experience referred to biblical historiography, where the experience of salvation is analogous. This paper uses a conceptual approach to the sanctuary from the anthropological, architectural and pedagogical perspectives so that the 21st-century student can appropriate the critical concepts of this biblical truth. The use of mobile technology encourages learning and motivates visitors to explore the semantic and transcendental depth behind the Exodus sanctuary.
Formacio?n de poli?ticas pu?blicas para la garanti?a de derechos humanos
Authors: Sánchez Cubides Pedro Alfonso , Higuera Jiménez Diego Mauricio
Published: May 2021

Resumen

El presente arti?culo aborda las poli?ticas pu?blicas como medio que tiene el Estado para respetar, proteger, garantizar y promover los derechos humanos, a trave?s de planes programas, proyectos y actividades, en cuyo proceso de formacio?n la participacio?n de la sociedad es fundamental. Bajo la perspectiva del Estado Social de Derecho, cuyo presupuesto es la dignidad humana, la formacio?n de poli?ticas pu?blicas con ma?s relevancia debe orientarse a la materializacio?n de derechos, proceso para el cual es de gran utilidad el enfoque basado en derechos, cuyos elementos se concretan en la delimitacio?n del derecho, las obligaciones del Estado y los principios transversales.

PALABRAS CLAVES: Estado, poli?ticas pu?blicas, derechos humanos, enfoque basado en derechos.

Abstract

This article deals with public policies as a means for the State to respect, protect, guarantee and promote human rights, through plans, programs, projects, and activities, in whose training process the participation of the society is fundamental. Under the perspective of the Social Rule of Law, whose budget is human dignity, the formation of public policies with more relevance should be oriented to the embodiment of rights, a process for which the rights-based approach is quite useful, whose elements are specified in the delimitation of the law, the liabilities of the State and the cross-cutting principles.

KEYWORDS: State, public policies, human rights, rights-based approach.

Resumo

O presente artigo aborda as poli?ticas pu?blicas como meio que o Estado tem para respeitar, proteger, garantir e promover os direitos humanos, atrave?s dos planos programas, projetos e actividades, cujo proceso de formac?a?o da participac?a?o da sociedade e? fundamental. Sob a perspectiva do Estado Social de Direito, cujo presuposto e? a dignidade humana, a formac?a?o de poli?ticas pu?blicas com mais releva?ncia deve orientar-se a? materializac?a?o de direitos, processo para qual e? de grande utilidade o enfoque baseado em direitos, cujos elementos se concretizam na delimitac?a?o do direito, nas obrigac?o?es do Estado e nos princi?pios transversais.

PALAVRAS CHAVE: Estado, poli?ticas pu?blicas, direitos humanos, enfoque baseado em direitos.
Tecnologi?a de la informacio?n y comunicacio?n en las operaciones psicolo?gicas en oficiales alumnos del escuela te?cnica del ejercito
Authors: Chingo Saavedra Alcides , Vásquez Tolentino Emerita Victoria
Published: May 2021

La tecnologi?a de la informacio?n y comunicacio?n es parte de la modernizacio?n y el avance cienti?fico al tiempo que un alto i?ndice de la poblacio?n tiene acceso, como parte de su trabajo diario, su avance acade?mico, su distraccio?n o como parte de la interaccio?n social, por tanto podri?a ser una herramienta importante en el trabajo de Operaciones Psicolo?gicas, por el nivel de accesibilidad de la poblacio?n en general, por tal motivo se asume que el te?cnico del ejercito debera? capacitarse y actualizarse en herramientas informa?ticas. El presente es un trabajo de reflexio?n que aborda en una propuesta de intervencio?n en la formacio?n acade?mica de los Te?cnicos del Eje?rcito en la especialidad de operaciones psicolo?gicas

PALABRAS CLAVE: tecnologi?a, informacio?n, comunicacio?n, operaciones psicologicas y ejercito

Abstract

Information and communication technology is part of the modernization and scientific advancement while a high rate of the population has access, as part of their daily work, their academic progress, their distraction or as part of social interaction, for This could be an important tool in the work of Psychological Operations, due to the level of accessibility of the population in general, for this reason it is assumed that the army technician must be trained and updated in computer tools. The present is a reflection work that addresses in a proposal of intervention in the academic training of Army Technicians in the specialty of psychological operations.

KEYWORDS: technology, information, communication, psychological operations, military

Resumo

A tecnologia da informac?a?o e comunicac?a?o e? parte da modernizac?a?o e do avanc?o cienti?fico ao mesmo tempo em que um alto i?ndice da populac?a?o tem acesso, como parte de seu trabalho dia?rio, seu avanc?o acade?mico, sua distrac?a?o ou como parte da interac?a?o social. Portanto, podia ser uma ferramenta importante no trabalho de Operac?o?es Psicolo?gicas, pelo ni?vel de acessibilidade da populac?a?o em geral. Por este motivo se assume que o te?cnico do exe?rcito devera? se capacitar y se atualizar em ferramentas informa?ticas. O presente trabalho reflexiona sobre essa abordagem em uma proposta de intervenc?a?o na formac?a?o acade?mica dos Te?cnicos do Exe?rcito na especializac?a?o de operac?o?es psicolo?gicas.

PALAVRAS CHAVE: tecnologia, informac?a?o, comunicac?a?o, operac?o?es psicolo?gicas e militares
Лазерное травление германия
Authors: Железнов В.Ю. , Малинский Т.В. , Миколуцкий С.И. , Рогалин В.Е. , Филин С.А. , Хомич Ю.В. , Ямщиков В.А. , Каплунов И.А. , Иванова А.И.
Published: May 2021

When studying the scanning of the polished surface of germanium single crystals by focused pulse-frequency radiation of an ultraviolet Nd:YAG laser, it was found that at subthreshold energy densities (at E ͠͠ 0.5–1.15 J/cm2), in the absence of noticeable traces of crater formation, laser etching was observed. It is assumed that the centers of ablation nucleation are dislocations coming out on the crystal surface.
Исследование влияния обработки лазерными импульсами наносекундной длительности на структуру субмикрокристаллического титана
Authors: Колобов Ю.Р. , Манохин С.С. , Одинцова Г.В. , Бетехтин В.И. , Кадомцев А.Г. , Нарыкова М.В.
Published: May 2021

The microstructure of a thin subsurface layer of VT1-0 titanium alloy samples in the initial submicrocrystalline state after exposure to nanosecond laser pulses has been studied using scanning and transmission electron microscopy (with the possibility of X-ray microanalysis).
Возбуждение молекул валина электронным ударом в газовой фазе
Authors: Шпеник О.Б. , Булгакова А.И. , Завилопуло А.Н. , Эрдевди Н.М. , Бандурин Ю.А.
Published: May 2021

The measurement procedure and the results obtained by optical spectroscopy upon excitation of valine molecules in the gas phase by slow electrons are described. The emission spectra of the molecules under study in the range of 200-520 nm with excitation by electrons in the energy range of 0-90 eV, as well as the optical functions of the excitation of the most intense spectral lines (bands) of radiation are presented.