bluuebunny/crossref_metadata_2025 huggingface dataset:
Unintended consequences of the potential phase-out of gamma irradiation
Authors: Chou Jacquelyn W , Skornicki Michelle , Cohen Joshua T
Published: March 2018

The radioisotope cobalt-60 (Co-60) is important for commercial, medical, and agricultural applications. Its widespread use has meant that Co-60 can be found in less secured facilities, leading to the fear that unauthorized persons could obtain and use it to produce a “dirty bomb”. This potential security concern has led to government calls for phasing-out Co-60 and other radiation sources, despite ongoing safety and security regulations for handling, transport and use of radioactive sealed sources.

This paper explores potential implications of phasing out radioisotopic technologies, including unintended safety and cost consequences for healthcare and food in the US and globally.

The use of Co-60 for healthcare and agricultural applications is well-documented. Co-60 is used to sterilize single-use medical devices, tissue allografts, and a range of consumer products. Co-60 is used in Gamma Knife treatment of brain tumors in over 70,000 patients annually. Co-60 is also used to preserve food and kill insects and pathogens that cause food-borne illness.

Co-60 is effective, reliable, and predictable. Limitations of alternative sterilization technologies include complex equipment, toxicities, incompatibilities with plastic, and physical hazards. Alternative ionizing radiation sources for wide-reaching applications, including e-beam and x-ray radiation, have advantages and drawbacks related to commercial scale capacity, penetrability, complexity and reliability.

Identifying acceptable alternatives would require time, costs and lengthy regulatory review. FDA testing requirements and other hurdles would delay replacement of existing technologies and slow medical innovation, even delaying access to life-saving therapies.  A phase-out would raise manufacturing costs, and reduce supply-chain efficiencies, potentially increasing consumer prices, and reducing supply.

These consequences are poorly understood and merit additional research. Given Co-60’s importance across medical and non-medical fields, restrictions on Co-60 warrant careful consideration and evaluation before adoption.
Strategies to alleviate shortages of nurses in adult social care
Authors: Glasper Alan
Published: March 2018

A lack of investment in adult social care has led to major staffing problems in care homes, according to a new report from the National Audit Office, as Emeritus Professor Alan Glasper, University of Southampton, explains
Supporting the family and relationships of a person with dementia in hospital
Authors: Mendes Aysha
Published: March 2018

Aysha Mendes, Freelance Journalist, specialising in health, psychology and nursing
Providing the right environment to develop new clinical nurse leaders
Authors: Leigh Jacqueline , Littlewood Lisa
Published: March 2018

Jacqueline Leigh, Reader, Teaching and Learning, School of Health and Society, University of Salford, J.A.Leigh4@salford.ac.uk , and Lisa Littlewood, Director of Placement and Practice Learning, School of Health and Society, University of Salford, evaluate the changes in the delivery of nurse education as a result of the devolution of health and social care decision-making from Westminster to Greater Manchester
Monitoring the Mental Health Act: a need to protect patients' rights
Authors: Tingle John
Published: March 2018

John Tingle discusses the latest Care Quality Commission annual report on how health services in England are applying the Mental Health Act 1983, which reveals with some worrying findings
Product evaluation of an absorbent, antimicrobial, haemostatic dressing
Authors: Stephen-Haynes Jackie , Toner Louise , Jeffrey Steve
Published: March 2018

This article reports on a product evaluation of KytoCel, an absorbent wound dressing used in the treatment of 30 wounds treated in community care and 10 split-thickness skin-graft donor sites treated in acute care. Within the community-treated cohort, unspecified leg wounds were the most common wound type (n=6) with the mean wound area of the 30 wounds being 17.6 cm2 (standard deviation (SD) 31.7) and mean volume being 8.4 cm3 (SD 21.4). Most community treated wounds (27/30; 90%) were reported to have moderate to high levels of wound exudate with the majority (n=19) either healed or improved during treatment. All ten split-thickness skin graft donor sites healed during the evaluation. A semi-structured focus group consisting of 17 nurses provided their opinions on KytoCel, with positive comments offered on the dressing during the focus group and of the 17 participants, 10 commented that the KytoCel dressing was available on their local wound care formulary.
Selecting appropriate postoperative dressings to support wound healing and reduce surgical site infection
Authors: Lumbers Melanie
Published: March 2018

The appropriate choice of postoperative dressing supports effective wound healing by providing a moist wound environment and reducing the risk of surgical site infection and blistering. Wound management is complex and practitioners need to consider the location of the wound, method of wound closure, expected exudate level and length of time the dressing needs to remain in place when selecting a product. The correct dressing selection will have a positive impact wound healing and the patient's quality of life.
Just one thing?
Authors: Harries Judith
Published: March 2018

Judith Harries explores picture books written by children's laureate Lauren Child, creator of popular characters Charlie and his little sister Lola. Use these to bring work with numbers and counting to life.
How to bee aware
Authors: Harries Judith
Published: March 2018

Bees are in the news at the moment due to the decline in their numbers and this makes it a good time to share lots of interesting facts about them. Engage children with a discovery table and a ‘bee aware’ day.
On balance
Authors: Hewson Claire
Published: March 2018

In the final part of her series on supporting core strength, Claire Hewson suggests games that involve catching and balancing. At the same time children will enjoy being involved in a team effort.
‘Look at this’!
Authors: Clarke Jenni
Published: March 2018

In the final article of this three-part series on story scribing and drama in different areas of the setting, Jenni Clarke explains how it can help children to feel their ideas are valued, and spur on their creativity.
Do Consumers Always Spend more when Coupon Face Value is Larger? The Inverted U-Shaped Effect of Coupon Face Value on Consumer Spending Level
Authors: Jia He (Michael) , Yang Sha , Lu Xianghua , Park C. Whan
Published: March 2018

Commonly, a coupon can be applied to one of several vertically differentiated products sold at different prices within the same product line of a brand. With such a product-line coupon, consumers need to decide on the specific product to buy, resulting in different levels of consumer spending. One field data set and four lab experiments demonstrate that the relationship between coupon face value and consumer spending level may not always be intuitively positive; under certain circumstances, it could take an inverted U-shape. The authors develop a threshold-based model to explain the inverted U-shaped effect of coupon face value on consumer spending level and show that this effect occurs when the price level of products is high, when consumers have a strong saving orientation, when they experience low information load from processing a small number of products, when they are inclined to engage in thorough product comparison, or when they have a weak preexisting preference for a specific level of product benefit.
Predictive Factors for the Positivity of the Sentinel Lymph Node in Malignant Melanoma
Authors: Crăciun Călin , Hankó-Bauer Orsolya , Benedek Zalán , Sorlea Sorin , Coroș Marius Florin , Georgescu Rareș
Published: March 2018

Malignant melanoma is a neoplasia that has its origin in the melanocytes, the melanin-synthesizing pigment cells present in the epidermis or sometimes in the dermis. Sentinel lymph node biopsy (SLNB) is the standard procedure used for staging patients with malignant melanoma in the majority of surgical centers in the world. With a probability of approximately 20% of finding positive lymph nodes, it spares a large number of patients of a complete lymphatic dissection. The aim of this study is to evaluate the factors that can predict the positivity of sentinel lymph nodes in malignant melanoma patients. We performed a retrospective study analyzing the histopathologic reports of patients who underwent SLNB for malignant melanoma between 2012 and 2015. There were 32 patients identified, out of which only three (9.37%) had positive SLN, so the majority of our patients were spared of regional lymphatic dissection. In our series, lymphatic invasion (p = 0.01), Breslow index >4 mm (p = 0.0064), AJCC staging (p = 0.0008), the presence of precursory lesions (p = 002), and microsatellitosis (p = 0.017) were predictive factors for the positivity of the SLN in malignant melanoma patients. Although our results are similar to those published in the literature, we consider that larger cohort studies should be performed to consolidate our results.
Chalk-induced Lung Fibrosis — Case Report
Authors: Szász Zsuzsánna Ágnes , Székely-Vass Enikő , Horváth Gyopár , Hozoi Mădălina
Published: March 2018

Introduction: Our article underlines the importance of a good professional anamnesis, knowing all the chemical components with which the patient had been exposed to during her active life as a teacher.

Case presentation: A 64-year-old female patient, teacher for 27 years, who had been retired for six years, presented cough with white phlegm and shortness of breath occurring during physical exertion, diffuse thoracic pain, and fatigue. Several lung functional tests were performed, which established the diagnosis of irreversible minor mixed ventilatory dysfunction. In order to establish the etiology of the patient’s symptoms, multiple clinical, laboratory, imaging, and functional investigations were performed including a chest radiograph, pulmonary functional testing, bronchial reversibility testing, a thoracic CT scan, fibrobronchoscopy, alveolar-capillary diffusion capacity measurement, otorhinolaryngology examination, thyroid ultrasound, as well as a cardiological consult. Finally, a positive diagnosis was established: bronchial hyperreactivity syndrome, chalk dust-induced diffuse pulmonary fibrosis.

Conclusion: An essential part of clinical practice is a proper anamnesis, including detailed information on the professional history and exposure, as well as the composition of the dust/particles with which the patient had been in contact with.
Time parallelization scheme with an adaptive time step size for solving stiff initial value problems
Authors: Bu Sunyoung
Published: March 2018

In this paper, we introduce a practical strategy to select an adaptive time step size suitable for the parareal algorithm designed to parallelize a numerical scheme for solving stiff initial value problems. For the adaptive time step size, a technique to detect stiffness of a given system is first considered since the step size will be chosen according to the extent of stiffness. Finally, the stiffness detection technique is applied to an initial prediction step of the parareal algorithm, and select an adaptive step size to each time interval according to the stiffness. Several numerical experiments demonstrate the efficiency of the proposed method.
Tropomyosin receptor kinase: a novel target in screened neuroendocrine tumors
Authors: Aristizabal Prada Elke Tatjana , Heinzle Vera , Knösel Thomas , Nölting Svenja , Spöttl Gerald , Maurer Julian , Spitzweg Christine , Angele Martin , Schmidt Nina , Beuschlein Felix , Stalla Günter K , Blaser Rainer , Kuhn Klaus A , Auernhammer Christoph J
Published: March 2018

Tropomyosin receptor kinase (Trk) inhibitors are investigated as a novel targeted therapy in various cancers. We investigated thein vitroeffects of the pan-Trk inhibitor GNF-5837 in human neuroendocrine tumor (NET) cells. The human neuroendocrine pancreatic BON1, bronchopulmonary NCI-H727 and ileal GOT1 cell lines were treated with GNF-5837 alone and in combination with everolimus. Cell viability decreased in a time- and dose-dependent manner in GOT1 cells in response to GNF-5837 treatment, while treatment in BON1 and NCI-H727 cells showed no effect on cellular viability. Trk receptor expression determined GNF-5837 sensitivity. GNF-5837 caused downregulation of PI3K-Akt-mTOR signaling, Ras-Raf-MEK-ERK signaling, the cell cycle and increased apoptotic cell death. The combinational treatment of GNF-5837 with everolimus showed a significant enhancement in inhibition of cell viability vs single substance treatments, due to a cooperative PI3K-Akt-mTOR and Ras-Raf-MEK-ERK pathway downregulation, as well as an enhanced cell cycle component downregulation. Immunohistochemical staining for Trk receptors were performed using a tissue microarray containing 107 tumor samples of gastroenteropancreatic NETs. Immunohistochemical staining with TrkA receptor and pan-Trk receptor antibodies revealed a positive staining in pancreatic NETs in 24.2% (8/33) and 33.3% (11/33), respectively. We demonstrated that the pan-Trk inhibitor GNF-5837 has promising anti-tumoral properties in human NET cell lines expressing the TrkA receptor. Immunohistochemical or molecular screening for Trk expression particularly in pancreatic NETs might serve as predictive marker for molecular targeted therapy with Trk inhibitors.
Assessment of LVEF using a new 16-segment wall motion score in echocardiography
Authors: Lebeau Real , Serri Karim , Di Lorenzo Maria , Sauvé Claude , Van Le Hoai Viet , Soulières Vicky , El-Rayes Malak , Pagé Maude , Zaïani Chimène , Garot Jérôme , Poulin Frédéric
Published: March 2018

Background: Simpson biplane method and 3D by transthoracic echocardiography (TTE), radionuclide angiography (RNA) and cardiac magnetic resonance imaging (CMR) are the most accepted techniques for left ventricular ejection fraction (LVEF) assessment. Wall motion score index (WMSI) by TTE is an accepted complement. However, the conversion from WMSI to LVEF is obtained through a regression equation, which may limit its use. In this retrospective study, we aimed to validate a new method to derive LVEF from the wall motion score in 95 patients.

Methods: The new score consisted of attributing a segmental EF to each LV segment based on the wall motion score and averaging all 16 segmental EF into a global LVEF. This segmental EF score was calculated on TTE in 95 patients, and RNA was used as the reference LVEF method. LVEF using the new segmental EF 15-40-65 score on TTE was compared to the reference methods using linear regression and Bland–Altman analyses.

Results: The median LVEF was 45% (interquartile range 32–53%; range from 15 to 65%). Our new segmental EF 15-40-65 score derived on TTE correlated strongly with RNA-LVEF (r = 0.97). Overall, the new score resulted in good agreement of LVEF compared to RNA (mean bias 0.61%). The standard deviations (s.d.s) of the distributions of inter-method difference for the comparison of the new score with RNA were 6.2%, indicating good precision.

Conclusion: LVEF assessment using segmental EF derived from the wall motion score applied to each of the 16 LV segments has excellent correlation and agreement with a reference method.
Clusterin deficiency induces lipid accumulation and tissue damage in kidney
Authors: Heo Jung-Yoon , Kim Ji-Eun , Dan Yongwook , Kim Yong-Woon , Kim Jong-Yeon , Cho Kyu Hyang , Bae Young Kyung , Im Seung-Soon , Liu Kwang-Hyeon , Song In-Hwan , Kim Jae-Ryong , Lee In-Kyu , Park So-Young
Published: March 2018

Clusterin is a secretory glycoprotein that is involved in multiple physiopathological processes, including lipid metabolism. Previous studies have shown that clusterin prevents hepatic lipid accumulation via suppression of sterol regulatory element-binding protein (SREBP) 1. In this study, we examined the role of clusterin in renal lipid accumulation in clusterin-knockout mice and NRK52e tubular epithelial cells. Clusterin deficiency increased the expression of SREBP1 and its target genes and decreased malonyl-CoA decarboxylase protein levels in the kidney. Expression of the endocytic receptor, megalin, and scavenger receptor class A was increased in clusterin-deficient mice. Functional analysis of lipid metabolism also revealed that lipid uptake and triglyceride synthesis were increased and fatty acid oxidation was reduced, leading to increased lipid accumulation in clusterin-deficient mice. These phenomena were accompanied by mesangial expansion, fibrosis and increased urinary protein-to-creatinine ratio. High-fat feeding aggravated these clusterin deficiency-induced pathological changes. Clusterin knockdown in NRK52e cells increased lipogenic gene expression and lipid levels, whereas overexpression of clusterin by treatment with adenovirus or recombinant clusterin protein suppressed lipogenic gene expression and lipid levels. Transforming growth factor-beta 1 (TGFB1) expression increased in the kidney of clusterin-deficient mice and suppression of TGFB1 in NRK52e cells suppressed lipid accumulation. These results suggest that clusterin deficiency induces renal lipid accumulation by dysregulating the expression of lipid metabolism-related factors and TGFB1, thereby leading to chronic kidney disease. Hence, clusterin may serve as a therapeutic target for lipid-induced chronic kidney disease.
Correlations of Aldehyde dehydrogenase-1 (ALDH1) expression with traditional prognostic parameters and different molecular subtypes of breast carcinoma
Authors: Sarkar Piyabi , Basu Keya , Sarkar Pubali , Chatterjee Uttara , Mukhopadhyay Madhumita , Choudhuri Manoj Kumar , Srakar Diptendra Kumar
Published: March 2018

Background and aim. Breast cancer, a heterogeneous disease, is the most common cause of cancer-related death in women worldwide. Despite considerable developments in treatment modalities, a subset of patients with advanced-stage breast carcinoma display poor prognosis. Breast cancer heterogeneity and risk of recurrence could be explained with the help of cancer stem cell hypothesis. Stem cells have the capacity to self-renew and differentiate into multiple cell types. Aldehyde dehydrogenase-1 (ALDH1), an enzyme responsible for the oxidation of intracellular aldehydes, contributes to normal and tumor stem cell differentiation. Invasion and metastasis in breast cancer are found to be mediated by a subpopulation of tumor cells which exhibit stem cell-like features and express ALDH1. The aim was to document ALDH1 expression in breast carcinoma and find its association with other clinico-pathologic prognostic parameters.Study design. This was a cross-sectional observational study.Methods. A total of 62 patients with breast carcinoma undergoing mastectomy were included in this study. The tumors were classified into molecular subtypes by assessing immunohistochemical (IHC) expression of ER, PgR, HER2 and Ki-67 according to St. Gallen Consensus Conference 2013. ALDH1 expression was studied by IHC and correlated with clinicoathological parameters.Statistical analysis. Statistical analysis was done using Graph Pad software (Prism 5 version) for Windows 7. A p-value <0.05 was considered statistically significant.Results and analysis. Out of 62 tumors, 35 tumors (56.4%) showed ALDH1 positivity. ALDH1 expression was significantly associated with larger size, lymph node involvement, higher grade, higher stage and HER2+ or triple negative tumors.Conclusion. This study suggests that ALDH1 expression is associated with poor prognostic parameters and aggressive tumor behavior. Larger population-based prospective trials on Indian patients are required to validate these results.
Energías limpias, poder local y procomún colaborativo
Authors: Hernández Luis Humberto
Published: March 2018

Se considera en el siguiente artículo que, a partir de los años setenta, la humanidad asiste al despliegue de una crisis civilizatoria, es decir, orgánica del sistema-mundo vigente hasta entonces. Que sea una crisis orgánica significa que han cambiado sus dos variables fundamentales: el paradigma o patrón energético y la pauta comunicacional que eran dominantes desde el siglo XVII. Esto conlleva cambios en las formas de gestión y de participación de la sociedad a lo largo y ancho del sistema y subsistemas que lo organizan. Con el desarrollo de estos supuestos se quiere indicar las ventanas de oportunidad que se le presentan en prospectiva a la sociedad colombiana, los retos que en la nueva escena política deben afrontar para su gestión, las fortalezas y debilidades que portan los actores políticos.
Petróleo, paz inconclusa y nueva lógica del conflicto
Authors: Sarmiento Libardo
Published: March 2018

Este artículo describe la relación entre petróleo y el antagonismo social, laboral y armado en Colombia, por este motivo se adentra en la coyuntura que vive el país, arriesgando una reflexión prospectiva sobre la matriz energética nacional y las nuevas lógicas del conflicto. La argumentación se sustenta en cuatro áreas connaturales a los conflictos que generan las actividades minero-energéticas: (1) los conflictos ambientales generados por la actividad extractiva basados en un escenario de iniquidad y segregación, que afectan territorios y culturas ancestrales, destruyendo recursos naturales estratégicos como la biodiversidad y el agua; (2) la concentración del ingreso, la riqueza y la propiedad de la tierra; (3) las economías de enclave y la ausencia de encadenamientos económicos regionales y locales con la explotación de hidrocarburos; y (4) la militarización (legal e ilegal) de la vida cotidiana y el aumento de la conflictividad por encima de la capacidad del sistema político regional y local para resolverlo.
New records of the Kinkajou, Potos flavus (Schreber, 1774) (Mammalia, Carnivora) in the Cerrado
Authors: Miranda Jefferson Eduardo Silveira , Melo Fabiano Rodrigues de , Fachi Marluci Baldo , Oliveira Seixas Rezende , Umetsu Ricardo Keichi
Published: March 2018

We provide new records of Potos flavus from 2 localities in the states of Goiás and Mato Grosso, central Brazil. These records extend the geographical distribution of this species in the Cerrado biome and highlights the importance of future research on this species. These new distributional data may contribute to a re-evaluation of its conservation status.
First record of the Woodland Blue Worm Octolasion cyaneum (Savigny, 1826) (Lumbricina, Lumbricidae) in the Colombian Andes
Authors: Tulande-M. Esteban , Pinzón-Garcia Patricia , Feijoo-M. Alexander , Barrera-Cataño José Ignacio
Published: March 2018

In South America, the European epi-endogeic lumbricid Octolasion cyaneum (Savigny, 1826) is known from Argentina, Chile, Brazil, Uruguay, and Ecuador. Here, we report this earthworm from Colombia for the first time. We found it in areas undergoing ecologic restoration in the Neusa Forest Reservoir, which is located in the department of Cundinamarca. Predominant vegetation in sampled areas is composed of Holcus lanatus, Hypochaeris radicata, and Anthoxanthum odorathum.
PENGEMBANGAN PERANGKAT LUNAK ANTAR-MUKA INSTRUMEN MOTIWALI (TIDE GAUGE) UNTUK ANALISIS DATA PASANG SURUT
Authors: Khatimah Husnul , Jaya Indra , Saleh Atmadipoera Agus
Published: March 2018

Instrumen MOTIWALI adalah alat untuk mengukur perubahan elevasi muka laut berbasis akustik, yang telah berhasil dikembangkan di Laboratorium Instrumentasi Kelautan ITK-IPB. Data hasil perekaman alat ini perlu dianalisis secara detail dengan membuat program untuk menentukan karakteristik komponen pasang-surut (pasut). Tujuan dari penelitian ini adalah untuk mengembangkan program antar-muka (software) yang dapat menganalisis data deret-waktu pasut dengan metode Admiralty, sehingga diperoleh komponen utama pasut serta menampilkan prediksinya. Pengembangan software mencakup empat modul, yaitu modul filter data untuk melakukan parsing dan pengelompokan data, modul Admiralty untuk analisis data pasut, modul Formzahl untuk penentuan tipe pasut, dan modul prediksi pasut. Data yang digunakan untuk uji-analisis software ini adalah data elevasi laut karena pasut hasil perekaman MOTIWALI selama 15 hari di Perairan Pulau Pramuka, Kep. Seribu. Perbandingan nilai amplitude dan fase komponen pasut antara hasil penelitian ini dengan data Dishidros, serta metode harmonik least-squared diperoleh nilai galat kuadrat terkecil (RMSE) sebesar 1.89 cm dan 102.27°, yang berarti akurasi hasil analisis dengan software ini cukup tinggi.  Jenis pasut di lokasi studi adalah harian tunggal (F=4.43), yang sesuai dengan penelitian sebelumnya. Modul prediksi fluktuasi pasut menampilkan hasil prediksi pasut yang memberikan informasi bermanfaat bagi aktivitas di kawasan studi.
Phenotypic correlation between leaf characters and physical and chemical aspects of cv. Vitória pineapple fruit
Authors: Küster Ivanildo Schmith , Alexandre Rodrigo Sobreira , Arantes Sara Dousseau , Schmildt Edilson Romais Schmildt , Arantes Lucio de Oliveira , Klem Dayane Littig Barker
Published: March 2018

Abstract By considering the few studies related to pineapple cv. Vitória, to know the relationships between the physical and chemical characteristics of the fruits, and they with the “D” leaf, is fundamental. The objective of this work was to evaluate the relationships between “D” leaf, with the physical and chemical characteristics of fruits of pineapple cv. Vitória, under the edaphoclimatic conditions in the North of the State of Espírito Santo. The experiment was carried out in a complete randomized block design in split-plot arrangement with four replications. The data obtained from 433 individually evaluated fruits were analyzed, as it follows: 84 at planting in July and induction at 8 months; 98 at planting in July and induction at 10 months; 84 at planting in July and induction at 12 months; 59 at planting in September and induction at 8 months; 50 at planting in September and induction at 10 months; 58 at planting in September and induction at 12 months. Pearson’s correlation was performed between the characteristics of “D” leaf (length and width) and the physical and chemical aspects of fruits (mass of the fruits with and without crown, fruit length and diameter, pulp volume, translucent area, soluble solids and titratable acidity) for the six treatments. Most of the relationships among the 11 characteristics evaluated were of low magnitude in the six treatments, but correlations of high magnitude and practical application of interest to plant scientists, breeders, farmers and consumers were found. The length and width of the “D” leaf should not be used as indicators of physical and chemical qualities of cv. Vitória. Fruits with higher mass, with or without crown or larger width or diameter present higher pulp content. Fruits with higher mass, with or without crown have lower content of soluble solids.
A POLÍTICA EDUCATIVA E SEUS EFEITOS NOS TEMPOS E ESPAÇOS ESCOLARES: A REINVENÇÃO DO ENSINO MÉDIO INTERPRETADA PELOS JOVENS
Authors: Correa Licinia Maria , Cunha Maria Amália de A.
Published: March 2018

RESUMO: O artigo descreve o que pensam, sentem e experimentam os jovens do ensino médio da rede pública estadual de Minas Gerais quando confrontados com a implementação de uma política educativa que, alicerçada em uma reformulação curricular, modifica tempos e espaços escolares. Inicialmente, o trabalho contextualiza o Projeto Reinventando o Ensino Médio e a pesquisa. Na primeira seção, discutimos as questões que permeiam a implantação do projeto na rede pública estadual mineira, no período de 2012-2014. Na segunda seção, analisamos a percepção dos jovens que vivenciaram a política em sua dimensão prática, explorando uma metodologia do tipo qualitativo baseada nos grupos focais. As falas dos jovens são reveladoras de como tais políticas colocam os sujeitos para as quais elas são endereçadas em um lugar quase invisível. Por fim, na terceira seção, tecemos algumas ponderações acerca dos resultados da pesquisa.
Quantitative and qualitative variables of semen from surubim do Iguaçu, Steindachneridion melanodermatum Garavello, 2005 (Siluriformes: Pimelodidae)
Authors: Sant’Anna J. F. M. , Moraes-Neto A. , Castro J. P. , Sczepanski T. S. , Pohv J. A. , Lopera-Barrero N. , Artoni R. F.
Published: March 2018

Abstract The objective of the present work was to assess the qualitative and quantitative characteristics of semen from the surubim do Iguaçu (Steindachneridion melanodermatum). Induced spermiation was achieved in eleven males with mean weight of 1.76 ± 0.48 kg and average age of two years and semen was collected by stripping. The average volume was 1.34 ± 0.73 mL. The duration of sperm motility was 154.4 ± 72.6 and 149.0 ± 77.5 seconds after activation with hatchery water and distilled water, respectively. The sperm concentration estimated by hemocytometer was 5.423 ± 2.155 x 1010 spermatozoa/mL. The results indicate that S. melanodermatum semen is easily obtained during the spawning season and the seminal characteristics are adequate insemination and subsequent in vitro fertilization.
Morphology of the spermatheca of Triatoma lecticularia (Hemiptera: Reduviidae) (Stal, 1859)
Authors: Monteiro M. F. , Lisboa L. C. O. , Carvalho-Costa T. M. , Nevoa J. C. , Oliveira C. J. F. , Serrão J. E. , Souza E. A.
Published: March 2018

Abstract Triatoma lecticularia (Hemiptera: Reduviidae) (Stal, 1859) is a potential vector of Chagas’s disease and the comprehension of its reproductive biology is an important tool to control this insect. In the reproductive tract of female insects, the spermatheca plays a crucial role storing male spermatozoa after mating. Whithin insects the spermatheca shows a wide morphological diversity and the analysis of this characteristic can contribute to understand the reproductive biology of the species. This study describes the histology and histochemistry of the spermatheca of T. lecticularia. Females have a pair of elongated spermathecal reservoirs without associated accessory gland. The reservoir opens into the common oviduct via a narrow muscular duct. The reservoir epithelium has single layer of columnar secretory cells. The control of the release of spermatozoa from the spermatheca occurs via the muscular duct. The anatomical features of the spermatheca of T. lecticularia resemble those described of other Reduviidae. However, the histological and histochemical features of spermatheca observed in T. lecticularia were important to explain the maintenance of the viability of the spermatozoa stored.
Fotos da Lua pelo Mundo: um projeto observacional registrado em fotografia sobre como as fases da Lua se comparam quando observadas dos Hemisférios Norte e Sul
Authors: Micha Daniel Neves
Published: March 2018

Resumo A Lua traz muita curiosidade para os habitantes da Terra. Diversos mitos e crendices associados ao movimento do astro figuram no imaginário popular, conferindo-lhe um papel que beira o místico e o sobrenatural. Contudo, muitos desses mitos, ou concepções alternativas, são errôneos e persistentes, mas poderiam ser questionados com a simples observação sistemática do nosso único satélite natural. Neste trabalho, o resultado de um projeto que visa auxiliar a elucidação de um dos mitos envolvendo a Lua é apresentado. Mais especificamente, busca-se responder à pergunta de como se comparam suas fases quando observadas de diferentes pontos do globo terrestre. Já que uma imagem vale mais que mil palavras, a questão é abordada através de registros fotográficos de observações da Lua feitas de diferentes latitudes e longitudes do planeta através do projeto Fotos da Lua pelo Mundo. O resultado é conforme o esperado: a fase da Lua é a mesma para qualquer observador, mas o formato percebido muda dependendo da latitude. Ciente de que a abordagem da astrofotografia é muito difícil de ser aplicada na prática em uma sala de aula, propõe-se o uso do programa de computador Stellarium a fim de gerar as imagens que embasam as discussões deste trabalho.
As leis de Newton e a estrutura Espaço-temporal da Mecânica Clássica
Authors: Antunes Camila A. , Galhardi Vinícius B. , Hernaski Carlos A.
Published: March 2018

Resumo Neste artigo, discutimos a estrutura das leis de movimento da mecânica clássica advinda de hipóteses gerais de simetria do espaço-tempo e do entendimento dessa teoria como sendo uma descrição efetiva para fenômenos macroscópicos. Usando argumentos de análise dimensional inspirados nas técnicas de teoria de campos efetivas, sustentamos em favor da naturalidade das leis de Newton da mecânica clássica.
Innovative digital design delivery for the Ordsall Chord in Manchester, UK
Authors: Duguid Brian , Hyde Jason , Pullan Howard
Published: March 2018

The Ordsall Chord rail link project in Manchester, UK was designed using building information modelling. Federated three-dimensional models produced by all design disciplines were held in a common data environment, with modelling developed down to the level of individual reinforcement bars. Early involvement of both the main contractor and its steel fabrication subcontractor allowed conventional roles and processes to be challenged. The design models and drawings were produced on the designer's behalf by the steelwork subcontractor, although these models and drawings were still owned by the structural designer. In some cases, drawings were dispensed with entirely, and key structures were built directly from the digital model, prepared in collaboration between fabricator and designer, and taking advantage of the fabricator's highly automated working method. This paper explains the contractual arrangements and collaborative behaviours that allowed conventional roles to be challenged, and discusses the efficiencies that resulted.
Use of incinerated ash as a cement component in concrete: compressive strength modelling
Authors: Lynn Ciarán J. , Dhir Ravindra K. , Ghataora Gurmel S.
Published: March 2018

This paper presents a model for the estimation of the compressive strength of concrete using incinerated ashes, municipal incinerated bottom ash and sewage sludge ash as an addition. Based on sourcing and systematic coordination of global data on this subject, an analysis of the properties of the ashes was undertaken. Collective data on the compressive strength performance of mortar and concrete mixes were also assessed. The strength model was then developed using a regression analysis approach, utilising the structure of the renowned Abram's law as the foundation, focusing specifically on the 28 d performance. The resultant model estimates can provide a greater focus for the initial trial testing undertaken when experimenting with the concrete mix design process with ashes. The model offers an informed view of how the properties of incinerated ash influence concrete strength, which can be useful for evaluating the quality of local ashes and avoiding unfavourable end-product performance.
TERSİYER BİR MERKEZDE TERM VAJİNAL MAKAT DOĞUMLARIN RETROSPEKTİF ANALİZİ
Authors: Eser Ahmet , Albayrak Betül , Tayyar Ahter Tanay , Kılıççı Çetin , Karakuş Resul , Yayla abide Çiğdem , Sağıroğlu Gülhan , Eroglu Mustafa
Published: March 2018

Amaç: Bu çalışmanın amacı term vajinal makat doğumların maternal ve fetal
sonuçlarını değerlendirmektir.Yöntem: Bu çalışmada Ocak 2014-Aralık 2017 tarihleri arasında kliniğimize doğum
için başvuran term gebelerden vajinal yolla doğum yapan makat gebelerdeki
maternal ve fetal sonuçlar değerlendirildi. Çalışma süresinde kliniğimizde 45
vajinal makat doğum gerçekleştiği saptandı. 
Maternal demografik veriler; yaş, gravida, parite, gestasyonel hafta ve
maternal travma değerlendirildi. Fetal sonuçlar olarak doğum kilosu, 1. ve 5.
dakika APGAR skorları, 5.dakika APGAR skorunun 7 olması, yenidoğan yoğun bakım ihtiyacı
olup olmaması ve fetal travma ve neonatal ölüm varlığı değerlendirildi.   Preterm makat doğumlar çalışmaya dahil
edilmedi.Bulgular: Çalışma süresince
45 term vajinal makat  doğum
gerşekleşmiştir. Gebelerin 2(%4) sinde maternal travmaya rastlanmış,
yenidoğanların 3(%7)ünde  doğum travması
görülmüştür. 2(%6) yenidoğan da 5.dakika APGAR7 idi. 13(%29) yenidoğana yoğum bakım
ihtiyacı gerekmiştir, bunların 4(%9) ünde fetal anomali mevcuttu. Neonatal ölüm
1(%2) yenidoğanda görülmüştür. Bu olguda fetal anomali nedeniyle
kaybedilmiştir.Sonuç: Term makat gebelerde planlanmış sezeryanla doğum yapıldığında mortalite
ve morbiditede azalma sağlanabilir. Düşük risk grubuna sahip gebelerde yakın
fetal moniterizasyon ve tecrübeli hekimlerin varlığında vajinal yolla doğum
sezeryanla doğuma alternatif olabilir.
Preparation of Nano Polymeric Thiophenes and Characterization of the Structures
Authors: SİVRİKAYA Sezen , DURMUŞ Sefa , DALMAZ Aslıhan
Published: March 2018

This
article describes a chemical oxidative polymerization for the preparation of
nano polymeric thiophene by using FeCl3 as oxidant. 2-thiophenecarboxaldehyde
(2-THCA) as monomer was used at polymerization process. The structure of
synthesized nano polymeric thiophene was confirmed by  scanning electron microscopy (SEM), Fourier
transform infrared spectroscopy (FTIR), Thermogravimetric analysis (TGA), Raman
Spectroscopy, and elemental analysis of C, H, O and S. SEM images showed that
the poly(2-thiophenecarboxaldehyde) (PTHCA) was synthesized in nanoscale and had
a homogeneous and smooth structure. The size of the synthesized nano particles
was not more than 35 nm. Thermal analysis of nano polymeric thiophene showed
thermally stable up to 512 OC. When elemental analysis results of PTHCA were
examined, it was seen that the obtained data after the synthesis of nano
polymeric thiophene and the determined data theoretically were agree with each
other.
A collocation method for solving boundary value problems of fractional order
Authors: Alkan Sertan , Seçer Aydin
Published: March 2018

In this paper, the sinc collocation method is used to obtain the solution of the second-order fractional boundary value problems based on the conformable fractional derivative. For this purpose a theorem is proved to represent the terms having fractional derivatives in terms of sinc basis functions. To show the efficiency and accuracy of the present method, some problems are solved and the obtained solutions are compared with the approximate solutions obtained by using the other numerical methods as well as the exact solutions of the problems.
Crescimento e Produtividade de genótipos de arroz de terras altas em Função de datas de Semeadura
Authors: Veroneis Luiz Fernando , Ferrari Samuel , Veroneis Gustavo Henrique
Published: March 2018

O objetivo deste trabalho foi avaliar diferentes genótipos semeados em diferentes períodos do ano, avaliando crescimento e produtividade. O estudo foi realizado na fazenda experimental da UNESP (Universidade Estadual Paulista) do Câmpus de Registro, SP. O delineamento experimental empregado foi o de blocos casualizados dispostos em esquema fatorial 4x4. Os tratamentos foram constituídos pela combinação de quatro genótipos de arroz em quatro épocas de semeadura, com quatro repetições totalizando 64 parcelas. Os genótipos selecionados para realização do experimento foram: ANA 7007, Moti Branco, Moti Amarelo e AN Cambará. As parcelas foram constituídas de cinco linhas com 5,0 m de comprimento cada, espaçadas em 0,35 m entre si totalizando uma área de 12,6 m2 cada parcela. Os genótipos apresentaram diferentes respostas, o AN Cambará demonstrou maior número de panículas por metro quadrado, o Moti Branco e Moti Amarelo apresentaram maiores altura de plântulas de arroz, o genótipo Moti Branco obteve a maior produtividade em todas as épocas de semeadura.

PALAVRAS-CHAVE: Oryza sativa L.; Produtividade; Baixa Fertilidade.
Espraiamento urbano e os impactos ambientais dos resíduos sólidos na Bacia Hidrográfica do Rio Gramame, em João Pessoa-PB
Authors: Sousa Cynthia Alves Félix de , Silva Milena Dutra da , Silveira José Augusto Ribeiro da
Published: March 2018

A urbanização das cidades, tanto na esfera global como nacional tem sido associada a problemas socioeconômicos e ambientais como, por exemplo, a redução dos espaços verdes e principalmente a poluição ambiental. Conforme ocorreu a urbanização, o constante crescimento populacional foi acompanhado pela produção incessante de resíduos, gerando diversos impactos ambientais, devido em parte a sua inadequada disposição. Estas questões relativas ao crescimento urbano e os impactos ambientais tem se constituído em um desafio às cidades, tornando-se cada vez mais relevantes as discussões acerca da necessidade de medidas que promovam sustentabilidade nos processos de desenvolvimento das cidades. A urbanização de João Pessoa, PB, se deu de maneira rápida e espraiada, direcionada para o sul do município, caracterizada pelos grandes espaços naturais necessários a qualidade ambiental, como por exemplo, a Bacia do Rio Gramame. Esta pesquisa objetivou diagnosticar os impactos ambientais urbanos provocados pelos resíduos sólidos urbanos na Bacia Hidrográfica do Rio Gramame, em João Pessoa-PB. Para tanto, realizou-se um levantamento dos impactos ambientais seguido da espacialização dos pontos de despejo de resíduos na área de estudo. Os resultados alcançados possibilitaram a geração de reflexões acerca do modelo de crescimento urbano da cidade na direção da Bacia Hidrográfica do Rio Gramame, bem como as carências nos sistemas de saneamento urbano e políticas de proteção ambiental.

PALAVRAS-CHAVE: Espraiamento Urbano. Impactos Ambientais. Resíduos Sólidos.
Composição química de íons majoritários na deposição úmida da cidade de São José do Rio Preto, Brasil
Authors: Medeiros Fabio Henrique , Martins Flavia Carla dos Santos , Bisinoti Márcia Cristina
Published: March 2018

Este trabalho tem como principal objetivo avaliar a influência da produção de álcool da cana-de-açúcar e da atividade industrial em uma cidade do estado de São Paulo na ciclagem de íons majoritários. Foram coletadas 103 amostras de deposição total e 96 amostras de deposição úmida apenas após cada evento de chuva usando três coletores na região noroeste do estado de São Paulo, entre março de 2009 e maio de 2010. Os parâmetros NH4+, NO3-, SO42-, PO43-, K+, pH e condutividade foram quantificados. Os resultados mostraram que as maiores variações nas amostras de deposição úmida ocorreu na seguinte ordem; PO43- > K+ > NO3- > NPOC > NH4+ > C.E. > SO42- ̴ TOC >> pH. Os maiores valores de pH foram observados durante o período de colheita (4,8 e 7,3). As concentrações de média ponderada do volume (VWM) para a deposição total e somente para molhado foram maiores durante o período de queima de cana para K+, NH4+, SO42-, PO43- and NO3. Para TOC e NPOC, maior VWM foram observados durante o período de queima de cana-de-açúcar para amostras de deposição total, observando-se o comportamento oposto para a deposição úmida. Para os valores de K+, NH4+ e SO42- VWM obtidos foram até 3,5 vezes maiores do que os valores encontrados para outras cidades impactadas pelas atividades de cana-de-açúcar no Estado de São Paulo. Com base nesses resultados, podemos ver que, durante o período de colheita de cana-de-açúcar, houve aumento em K+, NH4+, PO43- e NO3, indicando que esta prática contribui para a ciclagem desses elementos.
PALAVRAS-CHAVE: ions, deposição total, São José do Rio Preto.
Contribuição da deposição atmosférica como fonte de poluentes no principal corpo aquático da cidade de São José do Rio Preto, SP
Authors: Medeiros Fabio Henrique , Moreira Altair Benedito , Bisinoti Márcia Cristina
Published: March 2018

A atmosfera tem grande importância no transporte e distribuição de elementos, oriundos de atividades naturais ou antrópicas, sobre a superfície terrestre. A cidade de São José do Rio Preto (SJRP) possui um pequeno parque industrial, conta com a presença de duas rodovias de grande tráfego, a rodovia Washington Luís (SP-310) e a rodovia Transbrasiliana (BR-153), e em termos agrícolas a região é responsável por 12% da produção de etanol do estado, e em menor quantidade destaca-se o cultivo da laranja e de pastagens. Neste contexto o objetivo deste trabalho foi avaliar a contribuição da deposição atmosférica úmida (DU) e total (DT) como fonte de poluentes para o rio Preto, principal corpo aquático da cidade empregado para o abastecimento público. Em torno de 100 amostras de DU e DT foram coletadas entre o período de março de 2009 a setembro de 2010. A amostragem, preservação e quantificação de Al, Sb, As, Ba, Cd, Cu, Pb, Cr, Ni, Zn, K+, NH4+, PO43-, NO3-, SO42-, pH, C.E. e TOC (Carbono Orgânico Total) foi realizada seguindo recomendações de métodos oficiais.A contribuição da DU de Ni, Cd, Al, Ba, K+, NH4+, SO42- e TOC para o rio Preto foi inferior a 5% para, sendo que para Cr, Sb, Pb e As a maioria das amostras de DU apresentaram concentrações inferiores a 0,01 µg L-1. Já as contribuições mais expressivas foram observadas para Al e PO43- (53% e 233%). Conclui-se que a DT e DU na cidade de SJRP contribui como fonte de espécies químicas no ambiente aquático.
PALAVRAS-CHAVE: fonte difusa, deposição úmida, Rio Preto.
Environmental DNA (eDNA) 16S metabarcoding Illumina MiSeq NGS PCR Protocol v1
Authors: Closek Collin , Djurhuus Anni , Pitz Katie , Kelly Ryan , Michisaki Reiko , Walz Kristine , Starks Hilary , Chavez Francisco , Boehm Alexandria , Breitbart Mya
Published: March 2018

This protocol is aimed at amplifying the 16S rRNA hypervariable region 4 (16S V4) in prokaryotes. The primers (515fBand 806rB, 926R) used in this protocol are based on the primer utilized in Apprill et al 2015 and the Earth Microbiome Project (EMP). CitationApprill, A., McNally, S., Parsons, R. & Weber, L. Minor revision to V4 region SSU rRNA 806R gene primer greatly increases detection of SAR11 bacterioplankton. Aquat Microb Ecol 75, 129–137 (2015). doi:10.3354/ame01753 Earth Microbiom Projecthttp://press.igsb.anl.gov/earthmicrobiome/protocols-and-standards/16s/
PREGNANCY AND CHILDBIRTH IN PATIENTS WITH PRECANCER AND CERVIX CANCER
Authors: Levakov S A , Shablovskiy O R , Kedrova A G , Wanke N S , Nechaeva O V , Torubarov S F
Published: March 2018

The purpose of our study was the choice of the method with minimal harm to the reproductive health of women with early cervical pathology. We have analyzed the different techniques that can be used for the treatment of CIN or the early stages of cancer. There are sold-knife conization, laser conization, cryotherapy (freezing and destroying abnormal cells), laser vaporization (using a laser to destroy abnormal cells), loop electrosurgical excision procedure (LEEP). All procedures are threatening complications of pregnancy, for example, risk of miscarriage. Method with minimal complications had LEEP, including data on CIN recurrences and complications during pregnancy. Therefore, women who are considering future pregnancies should be counseled about these risks and benefits of procedures.
MODERN LOOK AT INFERTILE MARRIAGES
Authors: Levakov S A , Pavlova S A , Bugrova T I , Kedrova A G
Published: March 2018

Infertility is a common clinical and a public problem. It affects 13% to 15% of couples worldwide. Today, many patients do not receive the recommended medical care that based on the best available evidence. This paper, as a comprehensive review, deploys a new strategy to translate the research findings and evidence-based recommendations into a simplified focused guide to be applied on routine daily practice. It is an approach to disseminate the recommended medical care of infertile couple to the practicing clinicians. According to the literature survey, the most common causes of infertility are: male factor such as sperm abnormalities, female factor such as ovulation dysfunction and tubal pathology, combined male and female factors and unexplained infertility; where no obvious cause could be detected. Treatment begins with the reasons for having a high priority. Initially eliminate anatomical changes, then the functionality. The paper presents a clinical case of successful pregnancy after combined treatment of the couple.