bluuebunny/crossref_metadata_2025 huggingface dataset:
USO DE TERAPIAS BIOMODULADORAS NO TRATAMENTO DE DISFUNÇÕES DA REGIÃO ÍNTIMA EM MULHERES: ESTADO DA ARTE
Authors: Sampaio Rosane dos Santos , Cerqueira Carla Barreto Silva de , Medrado Alena Ribeiro Alves Peixoto
Published: October 2024

Introdução: Terapias biomoduladoras como o Ultrassom Microfocado, a Fotobiomodulação LASER e LED e a Radiofrequência tem sido cada vez mais utilizadas para tratamento de disfunções íntimas em mulheres. Objetivo: Compilar evidências científicas acerca dos principais efeitos decorrentes do uso de terapias não-invasivas para o manejo de disfunções íntimas em mulheres, assim como documentar seus protocolos de tratamento descritos na literatura. Metodologia: Trata-se de uma revisão integrativa da literatura, cuja busca por artigos científicos foi realizada nas bases de dados, por meio de descritores da biblioteca virtual em saúde (DeCS), a saber, Laserterapia Vaginal E Fotobiomodulação, Laserterapia Vaginal E Radiofrequência, Ultrassom Microfocado, com seus correspondentes na língua inglesa. Foram incluídos estudos que abordaram as terapias estéticas não-invasivas para o tratamento de disfunções íntimas, publicados no período de 2014 a 2024 disponibilizados integralmente para leitura. Resultados: o Ultrassom Microfocado tem sido indicado para o tratamento de disfunções diversas da região íntima, promovendo respostas no índice de saúde vulvar. A fotobiomodulação LASER e/ou LED tem sido apontada como uma terapia inovadora para tratar síndromes geniturinárias. Estudos sobre o uso do sistema de Radiofrequência têm relatado resultados promissores, com a adoção de diferentes protocolos para o tratamento das disfunções íntimas. Conclusão: A literatura aponta para o possível potencial de ação benéfico das terapias não-invasivas citadas no manejo de disfunções na região íntima, no entanto, constatou-se que sua aplicabilidade clínica e acessibilidade ainda são limitadas.
Urogynecological symptoms and pelvic floor muscle tender points in women with and without fibromyalgia
Authors: Melo Sathler Prado Tirza , Piccini Adriana , Monteiro Silvia , Bardin Marcela , Riccetto Cássio , Emmanuel Pedro de Teixeira Lucas , Botelho Simone
Published: October 2024

Aims: To compare the urinary, sexual and vaginal symptoms frequency, pelvic floor muscles (PFM) tender points and pain severity in women with and without fibromyalgia. Methods: Cross-sectional study composed by women with fibromyalgia (FMG) and without it (control group, CG) assessed by: (a) sexual (Female Sexual Function Index - FSFI); (b) vaginal (International Consultation on Incontinence Questionnaire ICIQ-Vaginal Symptoms); (c) urinary (ICIQ: Urinary Incontinence Short Form ICIQ-UI SF and ICIQ-Overactive Bladder  ICIQ-OAB); (d) quality of life (King’s Health Questionnaire - KHQ), as well as digital palpation assessment of: tone (normal, increased or decreased); tender points (position by clock-face); and pain severity (numeric rating scale - NRS). Statistical analysis included Student’s t-test, Wilcoxon-Mann-Whitney’s, logistic Regression and Spearman’s Correlation (significance level: 5%). Results: Of the 84 women enrolled, 39 FMG and 39 CG completed the study. No differences in urinary or vaginal symptoms were found. FMG presented lower FSFI (FMG: 7.2; CG: 21.6; p<0.001), more PFM tender points (FMG: 10 (25.6%); CG: 1 (2.6%); p=0.03), greater quality of life impairment (FMG: 5, CG: 4; p=0.01) and sleep/energy   (FMG: 5, CG: 2, p<0.01) both KHQ domains. The pain severity was FMG: 4 (1-6); CG: 7(7); p=0.05. Conclusion: More PFM tender points, greater impairment in sexual function, as well as in quality of life were all more frequent in women with fibromyalgia when compared to healthy controls. However, the correlation between sexual function and PFM pain was low.
PERCEPÇÃO BIOLÓGICA DO MOVIMENTO HUMANO EM INDIVÍDUOS COM DOENÇA DE PARKINSON: ESTUDO PILOTO
Authors: Soares de Araújo Denise , Cabral de Oliveira Marcella , Lopes Barreto Rodrigo , Célia Brasil Pedrina , De Oliveira Cacho Roberta , Walker Azevedo Cacho Enio
Published: October 2024

Objetivo: Avaliar a Percepção Biológica do Movimento de indivíduos com Doença de Parkinson (DP). Métodos: O estudo caracteriza-se como um estudo transversal e analítico, de caráter quantitativo, composto por um Grupo experimental (GDP), composto por cinco pacientes com DP, e um Grupo Controle (GC), com cinco indivíduos saudáveis, que foram avaliados por meio de instrumentos clínicos e cognitivos, e ambos, submetidos a um teste laboratorial para avaliar a PBM humano. O PBM foi avaliado por meio de movimentos humanos representados pela técnica de animações em luz pontual, divididos em três grupos de movimentos (relações sociais e funcionamento interpessoal, voltados a objetos, e movimentos biológicos funcionais), que totalizaram 12 representações de movimento (tarefas). As variáveis de desfecho utilizadas no estudo foram o número de acertos e o tempo de resposta de cada tarefa. Resultados: Os resultados demonstraram que o GC apresentou um melhor desempenho, apresentando maior número de acertos nas tarefas de reconhecimento e conseguiu realizá-las em um menor tempo, quando comparadas ao GDP. No entanto, não foram encontradas diferenças estatísticas entre os grupos, para ambas as variáveis estudadas. Conclusões: Dessa forma, concluímos que não encontramos prejuízo na PBM humana em indivíduos com DP.
TREINAMENTO MUSCULAR INSPIRATÓRIO APLICADO EM PACIENTES COM DOENÇA PULMONAR OBSTRUTIVA CRÔNICA: REVISÃO INTEGRATIVA
Authors: Lins Freitas Annicia , Maria Lacerda de Oliveira Carneiro Hellen , Flechas Arruda Perdigão Kauane , Pedrosa Rafaela , Heriston de Morais Lima José , Eriko Tenório de França Eduardo
Published: October 2024

Introdução: A doença pulmonar obstrutiva crônica (DPOC) é uma obstrução das vias aéreas, que impossibilita a respiração adequada e ocasiona diferentes disfunções no corpo humano. Objetivo: Avaliar os efeitos do treinamento muscular inspiratório (TMI) em pacientes com DPOC, visando identificar, na literatura científica, as estratégias contemporâneas empregadas e seus resultados. Métodos: Revisão de escopo da literatura, abordando as formas de aplicação do TMI, bem como a carga, frequência e seus efeitos. Foram incluídos artigos dos últimos 5 anos, abrangendo ensaios clínicos. As bases de dados consultadas foram a Cochrane, Lilacs, Medline e Pubmed. Os descritores foram “COPD”, “Breathing Exercises”, e “Respiratory Muscle Training”, e o operador booleano “and”. Os dados extraídos foram organizados em instrumentos elaborados pelos autores. Resultados: Nove artigos selecionados mostraram que o programa de reabilitação pulmonar envolvendo o TMI oferta efeitos positivos quando comparados com programa de reabilitação pulmonar sem TMI.  Geralmente, os treinamentos ocorrem num período de 3 a 8 semanas, 3 a 5 vezes por semana, e a carga é a partir de 30% da pressão inspiratória máxima, sendo aumentada progressivamente conforme as adaptações dos pacientes. Conclusão: Os estudos apontaram que o TMI no programa de reabilitação pulmonar entrega resultados significantes quanto a dispneia, capacidade funcional, força muscular inspiratória, padrão ventilatório, modulação autonômica cardíaca, equilíbrio, marcha e qualidade de vida.
Nowy ateizm
Authors: Sieczkowski Tomasz
Published: October 2024

Być może pojęcie światopoglądu pozwala nam wyrazić to, co w nas zachowawcze. […] Światopoglądy to nasze punkty oparcia, autoidentyfikacje pozwalające zachować poczucie stałości, sposoby naszego uczestnictwa w kulturze, ale zarazem narzędzia rekonstruowania samej kultury pod kątem naszych oczekiwań i preferencji. Owo pragnienie poczucia stałości – które wcale nie musi być tym samym, co rzeczywista stałość – jest być może kluczem do zrozumienia światopoglądu neoateistycznego, ale też sprawia, że bardziej przychylnie można spojrzeć na światopoglądy konkurencyjne wobec nowego ateizmu. Są one w pewnym sensie źródłowo filozoficznymi pamiątkami po dawnym świecie metafizycznej stabilności, jednak pamiątkami żywymi, ewoluującymi już według nowych reguł ponowoczesnych narracji, w świecie globalnego rozproszenia, wymuszonej mobilności, epistemologicznej rywalizacji. Dlatego o światopoglądach trudno pisać jako o teoretycznej abstrakcji, stają się nią bowiem dopiero wtórnie, w naszym zawsze o krok spóźnionym wobec nich opisie. Z istoty tego, co napisałem powyżej, wynika, że dużo lepiej przyjrzeć się im w ich działaniu: formowaniu i osiąganiu dojrzałości. O tym traktuje ta książka.
Fragment publikacjiNowy ateizm. Rekonstrukcja światopoglądu
Ocenianie wspierające w budowaniu jakości praktyki edukacyjnej szkoły
Authors: Kowalewski Michał
Published: October 2024

Niniejsza monografia poświęcona jest zagadnieniu szkolnego oceniania uczniów w perspektywie wspierania ich rozwoju, a także orientowania działalności edukacyjnej z właściwym wykorzystaniem uczniowskich możliwości i potencjału, co pozostaje jednym z wyznaczników jakości praktyki edukacyjnej realizowanej przez współczesną szkołę.
Opracowanie ma charakter teoretyczno-empiryczny i jest adresowane zarówno do nauczycieli, jak również studentów kierunków pedagogicznych, a także do czytelników, którzy wspieranie edukacyjnego rozwoju uczniów oraz jakość praktyki edukacyjnej realizowanej przez szkołę postrzegają jako zagadnienia istotne, warte namysłu i refleksji.
W teoretycznej części pracy podjęta została próba wyjaśnienia pojęcia jakości w kontekście praktyki edukacyjnej realizowanej w szkole, a także próba zdefiniowania pojęcia oceny szkolnej i procesu wartościowania osiągnięć uczniów z uwzględnieniem różnych modeli oceniania obecnych we współczesnych systemach oświatowych. Wyjaśnione zostały także elementarne zagadnienia związane ze wspierającym ocenianiem edukacyjnych osiągnięć uczniów, a także rolą oceniania wpierającego w budowaniu jakości praktyki edukacyjnej szkoły.
W części empirycznej przedstawiona została autorska koncepcja badań ilościowych wraz z analizą uzyskanych wyników dotyczących procesu oceniania, jaki w kontekście modelowych założeń oceniania wspierającego, obecny jest w szkolnej praktyce edukacyjnej. Wspomniane zagadnienia rozszerzone zostały o elementy metodologicznej komparatystyki (porównanie wyników badań przeprowadzonych w szkołach, w których jakość realizowanej praktyki edukacyjnej jest zróżnicowana), omówiono także wyniki procedury badawczej dotyczące modelu oceniania wspierającego i różnicowania poziomu jego realizacji przez dziedziny kształcenia.
Más allá del título y modo: transferencia de propiedad en el Perú a 40 años del Código Civil de 1984
Authors: Arribas Irazola Guillermo José
Published: October 2024

Luego de 40 años de vigencia del Código Civil de 1984, el autor revisa y cuestiona el grupo de normas que regulan la transferencia de la propiedad en el Perú. Teniendo en especial consideración el hecho de que las reglas generales de transferencia de propiedad en el libro de Derechos Reales no han tenido ninguna modificación desde su emisión en 1984, el autor desarrolla estas normas junto con aquellas que complementan nuestro sistema de transferencia de propiedad, y las principales discusiones que se han dado sobre estas materias en los últimos 40 años.En cada caso, se evalúa la coherencia del sistema y la relevancia de potenciales modificaciones. El autor propone reformas concretas a esta sección del Código Civil con el objetivo de asegurar la adaptabilidad de las normas de transferencia de propiedad a nuevos tiempos.
El carácter de las normas sobre la interpretación de los contratos
Authors: Forno Flórez Hugo
Published: October 2024

Las cláusulas de interpretación de los contratos son herramientas otorgadas por el Código Civil. La discusión sobre el carácter que poseen (imperativas o meras sugerencias) ha sido un largo debate doctrinario e incluso legislativo. El autor mediante un recorrido histórico y teórico de esta institución alrededor del mundo, pero sobre todo de las legislaciones europeas –que son la influencia de la nuestra–se pronuncia al respecto y sostiene que existe, en realidad, una dualidad en la naturaleza de estas normas (imperativas y dispositivas), puesto que estas categorías, en el contexto en el que han sido usadas, no serían mutuamente excluyentes.La importancia de entender de este modo estas reglas radica en que solo así se logra un balance entre la seguridad jurídica y la libertad contractual.
Comentarios a la legislación y a la jurisprudencia del contrato de arrendamiento en el Perú a los 40 años de vigencia del Código Civil
Authors: Villota Cerna Marco
Published: October 2024

El presente artículo realiza un análisis de la regulación del contrato de arrendamiento en el Código Civil y normas conexas, desde un punto de vista de la jurisprudencia y del derecho comparado, para sugerir algunos cambios normativos o criterios de interpretación a los 40 años de vigencia del Código Civil peruano. El trabajo analiza la relación entre el arrendamiento y el derecho de posesión para distinguirlo del derecho real de uso y de usufructo; trata el subcontrato de arrendamiento para delimitar las responsabilidades del subarrendatario y sobre todo, se centra en el tema de la duración del contrato de arrendamiento, a propósito de la discusión si el arrendatario con contrato vencido tiene la calidad de ocupante precario. Finalmente, analiza las diversas formas de conclusión del contrato de arrendamiento, las causales del proceso de desalojo y las diversas clases de proceso, a fin de hacer más ágil el proceso de desalojo.
La donación remuneratoria: una aproximación crítica a su naturaleza y a sus alcances
Authors: Bautista Quispe Ulises
Published: October 2024

La donación remuneratoria tiene un tratamiento parcialmente diferente al de una donación ordinaria; no se le aplican las normas de la revocación ni las de la obligación de alimentos (entre ellas las normas que protegen la legítima). Sin embargo, en el Código Civil se omite tal tratamiento y existe una tendencia a equipararla a un acto oneroso o a un pago, lo cual no es raro encontrar también en varios sectores de la doctrina nacional y extranjera.El autor critica estas posturas, señalando varias deficiencias, y sostiene que la donación remuneratoria es un subtipo de donación que se celebra de manera libre. Además, argumenta que la donación remuneratoria no debe ser equiparada con los intereses mercantiles, dada su esencia y los valores que promueve. Asimismo, ante la laguna legal en el Código Civil, el autor identifica y precisa el alcance que debería tener este contrato.
Limitaciones a la propiedad. En las limitaciones privadas: ¿el Tribunal Registral tiene facultad para legislar?
Authors: Ortiz Pasco Jorge
Published: October 2024

El artículo desarrolla la diversidad de limitaciones al derecho de propiedad en el Perú, muchas de ellas pasadas por alto, pero muy necesarias de conocer. En esta tarea, el autor también se posiciona frente a la polémica restricción en la transferencia y gravamen de bienes por acuerdo entre privados.Sobre algunas limitaciones se ha pronunciado la máxima instancia administrativa registral: el Tribunal Registral; el autor cuestiona su facultad legislativa mediante un análisis de los cambios que han propiciado los plenos LXII, XCIV y XCIX, además de los pronunciamientos de Tribunal Constitucional y lo establecido en el Código Civil de 40 años de vigencia.
Histopathology of liver, kidney, intestine, spleen, and bile of catfish with Jaundice
Authors: Asrido Farhan , Nuryati Sri , Widanarni Widanarni
Published: October 2024

Jaundice is a disease that can affect catfish, resulting in low or unsalable selling prices. The yellow colour in catfish is associated with tissue/organ disorders, particularly bile or liver function. This study aims to compare the histopathological structure of the liver, kidney, intestine, spleen, and bile of naturally jaundiced catfish and those injected with bacteria associated with jaundice. The study employed the observation method, using three variables: healthy catfish as a control (K), yellow catfish treated with Aeromonas spp. bacteria associated with jaundice (KP), and yellow catfish from the farm (KL). The results of the observation showed that the field scale variable (KL) had a higher level of necrosis damage in each organ compared to the laboratory scale variable (KP). The yellow colour in catfish is caused by disrupted organ tissue, particularly in the bile or liver. This can be observed in the liver, intestines, kidneys, spleen, and bile, where the field variable consistently indicates high levels of necrosis damage, with scores ranging from 1.11 to 2.48. Some of these scores indicate moderate damage, with a necrosis percentage of 40% ≤ P < 60% in the liver, kidneys, and bile organs.
Keyword: Clarias sp., histopathology, jaundice, necrosis
 
ABSTRAK
 
Salah satu penyakit yang menyerang ikan lele adalah penyakit kuning atau dikenal juga dengan jaundice, yang dapat mengakibatkan harga jual menjadi rendah atau bahkan tidak dapat dijual. Warna kuning pada ikan lele dikaitkan dengan gangguan jaringan / organ, terutama empedu atau fungsi hati. Penelitian ini bertujuan untuk membandingkan struktur histopatologi organ hati, ginjal, usus, limpa, dan empedu ikan lele yang sakit kuning baik yang alami maupun yang diinjeksi dengan bakteri  yang berasosiasi dengan penyakit kuning. Penelitian ini menggunakan metode observasi dengan tiga variabel yaitu ikan lele sehat sebagai kontrol (K), ikan lele kuning yang diberi perlakuan injeksi dengan bakteri yang berasosiasi dengan penyakit kuning yaiatu bakteri Aeromonas spp. (KP), dan ikan lele kuning yang berasal dari farm (KL). Hasil pengamatan yang diperoleh menunjukkan bahwa variabel skala lapangan (KL) memiliki tingkat kerusakan nekrosis paling tinggi pada setiap organnya dibandingkan dengan variabel skala laboratorium (KP). Warna kuning pada ikan lele berhubungan dengan terganggunya jaringan organ terutama empedu atau fungsi hati. Terlihat pada organ hati, usus, ginjal, limpa, dan empedu bahwa variabel lapangan selalu mendapatkan skor tingkat kerusakan nekrosis yang tinggi dengan kisaran nilai skoring 1,11-2,48 yang sebagian tergolong kerusakan sedang dengan persentase nekrosis 40% ≤ P<60% pada organ hati, ginjal, dan empedu.
 
Kata kunci: Clarias sp., histopatologi, nekrosis, penyakit kuning
Larval rearing of kelabau fish Osteochilus melanopleurus, Bleeker 1852 with different live feed
Authors: Asiah Nur , Aryani Netti , Heltonika Benny
Published: October 2024

This study aimed to determine the effect of different starting feeds on the growth and survival rate of kelabau fish larvae (Ostechilus melanopleurus, Bleeker 1852). The research was conducted in a Complete Randomized Design (CRD), 3 treatments and 3 replicates. The tested animals used were 7-Dpc (Day post hatch) 90 kelabau fish (Ostechilus melanopleurus) larvae with an initial average length of 0.50 ± 0.06 cm and an initial weight of 0.03 ± 0.02 g. Treatment of one (P1) Artemia nauplii, (P2) Tubifex sp., and (P3) Daphnia. Aquarium research containers size 30×30×20 cm3 9 pieces with a volume of 5 L of water without water flow in the first week onwards from the second week to the 4th week are increased to 10 L with a water recirculation system with a water flow of about 0.5 L per minute. Measurement of the length and weight of the larvae is carried out once a week for 4 weeks. The results showed that the highest length and weight growth was obtained in the P2 treatment of 3.92 ± 0.13c cm and 1.25 ± 0.03c g, and the lowest growth was in the P3 treatment of 1.73 ± 0.05a cm and 0.093 ± 0.010a g. The ANOVA results showed that feeding Tubifex sp. had a very noticeable different effect with a value of P<0.01.
 
Keywords: feed type, Osteochilus melanopleurus, growth
 
ABSTRAK
 
Penelitian ini bertujuan untuk mengetahui pakan awal berbeda terhadap pertumbuhan dan kelulushidupan larva ikan kelabau (Ostechilus melanopleurus, Bleeker 1852). Metode Penelitian yang digunakan adalah metode eksperimen, dengan Rancangan Acak Lengkap (RAL), 3 perlakuan dan 3 ulangan. Hewan uji yang digunakan adalah larva ikan kelabau (Ostechilus melanopleurus, Bleeker 1852) umur 7 hari sebanyak 90 ekor dengan rata-rata panjang awal 0,50 ± 0.06 cm dan berat awal 0.03 ± 0.02 g. Perlakuan satu (P1) Nauplii Artemia, (P2) Tubifex sp. dan (P3) Kutu Air. Wadah penelitian akuarium ukuran 30×30×20 cm3 9 buah dengan volume 5 L air tanpa aliran air pada minggu pertama dan seterusnya dari minggu kedua sampai minggu ke 4 ditambah menjadi 10 L dengan sistem resirkulasi air dengan aliran air sekitar 0.5 L per menit. Pengukuran panjang dan bobot larva dilakukan seminggu sekali, selama 4 minggu. Hasil penelitian menunjukkan bahwa pertumbuhan panjang dan berat tertinggi ditunjukkan pada perlakuan P2 sebesar 3.92 ± 0.13c cm dan 1.25 ± 0.03c g, dan pertumbuhan terendah yaitu pada perlakuan P3 1.73 ± 0.05a cm dan 0.093 ± 0.010a g. Hasil ANOVA menunjukan bahwa pemberian pakan Tubifex sp. memberikan pengaruh berbeda sangat nyata dengan nilai P<0.01.
 
Kata kunci: Osteochilus melanopleurus, pertumbuhan, tipe pakan
LA PROCRASTINACION EN LA FORMACION DE LOS ESTUDIANTES DE SOCIOLOGIA DE LA UNIVERSIDAD JUAREZ AUTONOMA DE TABASCO
Authors: OVANDO LEYVA ANGEL MANUEL , RODRÍGUEZ FALCÓN MARGARITA
Published: October 2024

El presente artículo, aborda el derecho del acceso a la información como una herramienta en el combate a la corrupción dentro de los procesos electorales, la llegada de las nuevas tecnologías propicia un escenario adecuado para la desinformación de manera que se debe emplear las TIC como herramienta coadyuvante, es de vital importancia para la ciudanía el poder estar informado de los actores políticos, este derecho debe ser ejercido de manera analítica, la información debe ser concisa, metodológica, cuantitativa y cualitativa, el derecho a ejercer el voto es tan importante que no debe ser tomado a la ligera.
This article addresses the right of access to information as a tool in the fight against corruption within electoral processes. The arrival of new technologies provides a suitable scenario for disinformation, so ICTs should be used as an auxiliary tool. It is vitally important for citizens to be informed about political actors. This right must be exercised analytically, the information must be concise, methodological, quantitative and qualitative. The right to vote is so important that it should not be taken lightly.
Analysis of the potential of the electroactive biofilm growth in a microbial fuel cell type H
Authors: González-Nava Catalina , Canul-Chan Michel , Campos Juan , Caballero-Pérez Juan , Houbron Eric , Godínez Luis A. , Rodríguez-Valadez Francisco J.
Published: October 2024

Microbial fuel cells (MFC) constitute an attractive alternative as an environmental remediation technology since they can generate electrical current using organic waste as a substrate. Since the performance of MFCs depends on the characteristics of the biofilm on the anode surface, it is important to assess the genetic information of the microorganisms that grow on the electrode. For this purpose, a sewage sludge sample was obtained from a wastewater treatment plant and used to inoculate a type H MFC. Electrochemical characterization, on one hand, indicates that while the biofilm has a typical electrochemical performance reflected by the generated voltage (near 0.4 V) and by the electroactivity observed in cyclic voltammetry experiments, and on the other hand, the metagenomic analysis shows that the most abundant genera are Pseudomonacea, Nitrosomonas, Hyphomonas, and Opitutus. The study also indicates that the biofilm’s electroactive microorganisms can metabolize amino acids, lipids, and carbohydrates and possess genetic tools for ionic transport and energy production. Regarding the electron acceptor/donator capabilities, several oxidases, reductases, and complexes were identified, mainly terminal cytochrome C oxidase and respiratory complex I, which could be associated with the exoelectrogenic capacity of the microorganisms. Finally, the metagenomic information indicates that the biofilm can synthesize rhamnose, sialic acid, and alginate molecules, which could possibly be associated with the formation and consolidation of the microbial biofilm.
Regressive Machine Learning for Real-Time Monitoring of Bed-Based Patients
Authors: Joseph Paul , Ali Husnain , Matthew Daniel , Thomas Anvin , Jose Rejath , Mayer Jonathan , Bekbolatova Molly , Devine Timothy , Toma Milan
Published: October 2024

This study introduces an ensemble model designed for real-time monitoring of bedridden patients.The model was developed using a unique dataset, specifically acquired for this study, that captures six typical movements. The dataset was balanced using the Synthetic Minority Over-sampling Technique, resulting in a diverse distribution of movement types. Three models were evaluated: a Decision Tree Regressor, a Gradient Boosting Regressor, and a Bagging Regressor. The Decision Tree Regressor achieved an accuracy of 0.892 and an R2 score of 1.0 on the training dataset, and 0.939 on the test dataset. The Boosting Regressor achieved an accuracy of 0.908 and an R2 score of 0.99 on the training dataset, and 0.943 on the test dataset. The Bagging Regressor was selected due to its superior performance and trade-offs such as computational cost and scalability. It achieved an accuracy of 0.950, an R2 score of 0.996 for the training data, and an R2 score of 0.959 for the test data. The study also employs K-Fold cross-validation and learning curves to validate the robustness of the Bagging Regressor model. The proposed system addresses practical implementation challenges in real-time monitoring, such as data latency and false positives/negatives, and is designed for seamless integration with hospital IT infrastructure. This research demonstrates the potential of machine learning to enhance patient safety in healthcare settings.
Traces of Consciousness
Authors: Hoffman Donald , Prakash Chetan , Chattopadhyay Swapan
Published: October 2024

What is an observer? What is an observation? How do observations inform beliefs? What is the relationship between observers and physical objects in spacetime? These are central, and as yet unresolved, questions in the foundations of physics and consciousness science. We propose an answer taking consciousness as fundamental, resulting in a theory of conscious agents whose mutual interaction is governed by Markov chains. We describe observation via a new trace order on Markov chains. In this context, no observer is aloof: it must be an integral part of any system it observes. We find that the trace order forms a non-Boolean logic, mapping homomorphically to the “Lebesgue” logic” of probabilistic beliefs. We explore implications of conscious agent theory for the “hard problem” of consciousness, and propose a route to empirical tests using data from scattering experiments with subatomic particles.
Sustainability of Kikuyu Grass (Pennisetum clandestinum) for the Development of Highland Livestock Farming in the Northern Macro-Region of Peru
Authors: Alvarez-Garcia Wuesley , Díaz Arturo , Becerra Yessica , Vallejos-Fernández Luis A. , Florián Roy , Carrasco Chilón William Leoncio , Cervantes Peralta Marieta Eliana , Quilcate Carlos , Muñoz-Vilchez Yudith
Published: October 2024

The productive sustainability of Pennisetum clandestinum in the Peruvian highlands was evaluated through productivity, growth and chemical composition. The effect of the nitrogen (N2) dose applied to the soil, the use of organic matter and the frequency of cutting or phenological age on the productive yields, chemical composition, plant height and growth rate of Kikuyu were determined. Experimentation was carried out under a randomised block design in divided plots. A multivariate analysis of variance (MANOVA) was used to determine the associated differences in each study factor. It was determined that applying 120 kg of N2 increases the annual protein production to 3 454.53 kg ha-1. yr-1, and a crude protein (CP) level of 23.54%, the distance of the live fences influences the biomass production to 19 176.23 kg DM ha-1 at an interval of 8.5 to 11.5 meters from the base of the cypress tree (Cupressus lusitanica). Organic matter favours the biomass yield of Kikuyu. Although there is no difference in dry matter production between 30 and 60 days of cutting, CP production is higher at 30 (p<0.05). The highest DM production per day is obtained at 45 days, generating a higher biomass accumulation of 21 186.9 kg DM ha-1. yr-1. The consideration of Pennisetum clandestinum for dairy cattle is viable, taking into account that the possibility of implementing a plant improvement programme on this species is open, aimed at increasing the composition of the diet in high-production cows due to its high yield and good chemical composition in highland conditions.
LiDAR Technology for UAV Detection: From Fundamentals and Operational Principles to Advanced Detection and Classification Techniques
Authors: Seidaliyeva Ulzhalgas , Ilipbayeva Lyazzat , Utebayeva Dana , Smailov Nurzhigit , T.Matson Eric T
Published: October 2024

As UAVs are increasingly employed across various industries, the demand for robust and accurate detection has become crucial. LiDAR has developed as a vital sensor technology because to its ability to offer rich 3D spatial information, particularly in applications such as security and airspace monitoring. This review systematically explores recent innovations in LiDAR-based drone detection, deeply focusing on the principle and components of LiDAR sensor, its classifications based on different parameters and scanning mechanisms, as well as the approaches for processing LiDAR data. The review briefly compares several deep learning approaches, including point-based, voxel-based, and hybrid models, that have improved drone detection, tracking, and classification. We also explore the integration of multi-modal sensor fusion, which combines LiDAR data with other complimentary modalities to improve UAV detection and tracking in complex environments such as GNSS-denied zones.
Cerebral Amyloid-β Deposition, Axial Features and Cognitive Alterations in Parkinson’s Disease Patients Treated with Bilateral STN-DBS: A Long-term Cohort Study
Authors: Cavallieri Francesco , Fraternali Alessandro , Arnone Annachiara , Campanini Isabella , Marti Alessandro , Gessani Annalisa , Fioravanti Valentina , Molinari Maria Angela , Di Rauso Giulia , Antonelli Francesca , Rispoli Vittorio , Feletti Alberto , Stanzani Riccardo , Damiano Benedetta , Scaltriti Sara , Cavazzuti Lorenzo , Bardi Elisa , Corni Maria Giulia , Cavalleri Francesca , Biagini Giuseppe , Pavesi Giacomo , Lusuardi Mirco , Budriesi Carla , Merlo Andrea , Versari Annibale , Valzania Franco
Published: October 2024

Objectives: To evaluate the possible long-term cerebral deposition of amyloid-β in PD patients treated with subthalamic nucleus deep brain stimulation (STN-DBS) and its possible influence on axial and cognitive variables. Methods: Consecutive PD patients treated with bilateral STN-DBS with a long-term follow-up were included. Amyloid-β deposition was evaluated postoperatively through a 18F-flutemetamol positron emission tomography (PET) study. Axial symptoms have been assessed using a standardized clinical-instrumental approach. Speech was assessed by perceptual and acoustic analysis while gait by means of the instrumented timed up and go test (iTUG). Motor severity was evaluated applying the UPDRS part III score and subscores while cognitive functions through a complete neuropsychological assessment. Different stimulation and drug conditions were assessed: on-stimulation/off-medication, off-stimulation/off-medication, on-stimulation/on-medication conditions (single and dual task). Results: 19 PD patients (male: 11; age: 63.52 years; on-stimulation/on-medication UPDRS-III: 17.05) with a five-year postoperative follow-up were included. Amyloid-β deposition was found in 21% of patients (4/19) with a prevalent involvement of prefrontal, limbic and parietal areas. Compared with patients without amyloid-β deposition, PD patients with positive 18F-flutemetamol PET study showed higher preoperative UPDRS-I (p=.037) score and lower postoperative Raven's matrices scores (p=.05). Conclusions: Our results suggest that in the long-term after STN-DBS a significant percentage of PD patients may present brain amyloid-β deposition. However, larger samples are needed to evaluate the possible role of amyloid-β deposition in the development of axial and cognitive alterations after surgery.
HybridGNN: A Self-Supervised Graph Neural Network for Efficient Maximum Matching in Bipartite Graphs
Authors: Pan Chun-Hui , Qu Yi , Yao Yao , Wang Mu-Jiang-Shan
Published: October 2024

Solving maximum matching problems in bipartite graphs is critical in fields such as computational biology and social network analysis. This study introduces HybridGNN, a novel graph neural network model designed to efficiently address complex matching problems at scale. HybridGNN combines the capabilities of Graph Attention Networks (GAT), GATv2, and Graph SAGE (SAGEConv) layers, integrating techniques like mixed precision training, gradient accumulation, and Jumping Knowledge networks to enhance computational efficiency and performance. Additionally, the incorporation of Graph Isomorphism Networks (GIN) enhances the model's ability to discriminate between structurally different graphs. A time complexity analysis shows that HybridGNN achieves efficient computation across different layers. When evaluated on an email communication dataset, HybridGNN outperformed traditional algorithms such as Hopcroft-Karp, particularly on large and complex graphs. These results demonstrate that HybridGNN offers a powerful and efficient approach for solving maximum matching problems in bipartite graphs, with potential applications in various fields requiring analysis of large-scale and complex graph data.
Synthesis of Enantiostructured Triacylglycerols Possessing a Saturated Fatty Acid, a Polyunsaturated Fatty Acid and an Active Drug Intended as Novel Prodrugs
Authors: Jónsdóttir Lena Rós , Haraldsson Gudmundur G.
Published: October 2024

This report describes the asymmetric synthesis of a focused library of enantiopure structured tri-acylglycerols (TAGs) comprised of a single saturated fatty acid (C6, C8, C10, C12, C14 or C16), a pure bioactive n-3 polyunsaturated fatty acid (EPA or DHA) and a potent drug (ibuprofen or naproxen) intended as a novel type of prodrugs. One of the terminal sn-1 or sn-3 positions of the glycerol backbone is occupyed with a saturated fatty, the remaining one with a PUFA, and the drug entity is present in the sn-2 position. This was accomplished by a six-step chemoenzymatic approach starting from enantiopure (R)- and (S)-solketals. The highly regioselective immobilized Candida antarctica lipase (CAL-B) played a crucial role in the regiocontrol of the synthesis. All combinations, the total of 48 such prodrug TAGs were prepared, isolated and fully characterized, along with 60 acylglycerol intermediates, obtained in very high to excellent yields.
Systematic Characterisation of the Fragmentation of Flavonoids using High-Resolution Accurate Mass Electrospray Tandem Mass Spectrometry
Authors: Jiang Candy , Gates Paul Jonathan
Published: October 2024

Flavonoids are a class of polyphenolic secondary metabolites found in plants. Due to their ubiquity in our daily dietary intake and their major anti-oxidative, anti-inflammatory and anti-mutagenic activities, they have been a major focus of wide-ranging research for the past two decades. Mass spectrometry combined with liquid chromatography is one of the most popular techniques for the analysis of flavonoids. In this study, high-resolution accurate mass electrospray tandem mass spectrometry was used to study 30 flavonoids in both positive and negative ionisation modes. From the data obtained, common losses are summarised and compiled. Dominating neutral losses are tabulated. The radical loss of CH3. was observed in flavonoids containing methoxy groups and three diagnostic product ions were identified which could be useful in structural elucidation of unknown flavonoids and flavonoid metabolites. Energy breakdown graphs were utilised to dis-tinguish between three pairs of structural isomers, and to help rationalise proposed fragmentation pathways. Lastly, a competition of loss of CH3. and methane were reported for rhamnetin and isorhamnetin in the negative ion mode for the first time. Proposed fragmentation pathways were given to rationalise the differences in peak intensities for this competitive process.
Volumetric Assessment of the Maxillary Sinus After Maxillary Advancement and Impaction
Authors: Oliveira¹ Luana Ferreira , Pavelski Maicon Douglas , Lima Valthierre Nunes de , Filho Osvaldo Magro
Published: October 2024

Background: Orthognathic surgery is a surgical procedure that consists of osteotomies and maxillary movements aimed at facial harmony and occlusal repositioning. Methods: The present study aimed to perform a retrospective study using cone beam computed tomography (CBCT) to evaluate the air volume of the maxillary sinus and its attached structures, detection and diagnosis of anatomical defects, induced or not by maxillary advancement surgery - mandibular and/or maxillary impaction in two stages: preoperative (T0) and postoperative of at least 6 months (T1). Results: Of the 31 patients selected, it was found that the volume of the maxillary sinus had no statistically significant change, descriptively there were 6.45% for retention cyst and 32.25% for mucosal thickening, reduction in 6 cases of septal deviation in T1 that were present in T0 in patients undergoing maxillary advancement and impaction. Furthermore, it was possible to observe a decrease in postoperative cases of obstructed ostium and an increase in cases of patent ostium. Conclusion: That orthognathic surgery for maxillary advancement and/or impaction does not pose a risk to the health of the maxillary sinuses during the period analyzed.
Retrospective Evaluation of the Prevalence and Drug Susceptibility of Candida Species and an Analysis of Risk Factors for Oral Candidiasis
Authors: Tkaczyk Marcin , Kuśka-Kiełbratowska Anna , Niemczyk Wojciech , Skaba Dariusz , Wiench Rafał
Published: October 2024

This study retrospectively evaluated the prevalence and drug susceptibility of Candida species in patients diagnosed with oral mucosal candidiasis at the Department of Periodontal and Oral Mucosal Diseases, Silesian Medical University, from 2018 to 2022. A total of 1286 patients were examined (788 females, 498 males) through mycological testing to identify Candida strains and assess their drug resistance to amphotericin B, nystatin, flucytosine, econazole, ketoconazole, miconazole, and fluconazole. Among the 958 patients with positive results, Candida albicans accounted for 66.79% of infections, followed by non-albicans Candida (NAC) strains (33.21%), with rare strains identified in 0.82%. Drug resistance in C. albicans was less than 10% for most antifungals but reached 30% for azoles, while NAC strains exhibited more than 40% resistance, with C. krusei being the most resistant. Key risk factors for candidiasis included removable denture use and uncontrolled diabetes mellitus. The study highlights an increase in NAC infections, multi-strain infections, and decreasing efficacy of antifungal treatments, especially for NAC strains, with more severe cases observed in patients with multiple risk factors.
Gaia-X-Med: Experiences with Building Dataspaces for Medical Applications
Authors: Gerlach Bennet , Hesse Hannes , Fischer Stefan , Leucker Martin
Published: October 2024

Gaia-X, a European initiative, aims to create a digital sovereignty framework for service ecosystems in the future internet. Its applicability to the health domain has been explored in the Gaia-X-Med project, which aimed to establish a common dataspace for various medical use cases based on Gaia-X principles. This paper presents the approach to secure authentication and digital contract negotiation central to this endeavour and discusses the challenges that arose during adoption of the Gaia-X framework, in particular relating to the strict requirements of the European healthcare domain with regards to privacy and consent regulations. By exploring the practical implications of Gaia-X in the healthcare context, this paper aims to contribute to the ongoing discussions surrounding digital sovereignty of both citizens and corporations, as well as its realization via future internet technologies.
The Perceived Impacts of the Rio 2016 Paralympics on the Lives of Disabled Brazilians
Authors: Kirakosyan Lyusyena
Published: October 2024

The Paralympic movement leaders, sporting mega-event organizers, and para-athletes in Brazil and elsewhere made frequent claims about the potential of the Paralympics to raise disability rights awareness and generate change in society’s perceptions of disabled people. However, how disabled people themselves view the Paralympics and their outcomes is insufficiently explored in the media and academic literature. This article has a two-fold purpose: first, to explore the views and perceptions of disabled Brazilians regarding the societal change claims made about the Rio 2016 Paralympics; and second, to problematize these claims of lasting societal change through the lens of critical disability theory. The online qualitative survey conducted a year after the Rio mega-event explored the following issues: a) attitudes of broader society towards disabled people; b) disability sport as a tool for social inclusion and equality; c) para-athletes’ visibility and the broader challenges; d) images of disabled people in the Paralympic coverage; and e) outcome of media’s attention for disabled people in general. The main argument is that realizing the Paralympic legacy promises is more complex than the Paralympic movement leaders and the event organizers acknowledge and that the social change legacies are the responsibility of the larger community long after the Games are over.
ANALYSIS OF TUMBAORHYTHM PATTERNONCONGA IN NECESITAS TU
Authors: Margana Rangga , Saryanto  , Srimoko Gandung Joko , Retnowati Tjut Etty
Published: October 2024

The purpose of this study is to describe the results of the Analysis TumbaoRhythm PatternonConga in Necesitas Tu. The research method used is qualitative with a descriptive approach. This research was carried out from October 2020 to June 2021. The results of the study can be concluded that the most popular Basic of Latin Cuban is the tumbao pattern. The tumbao pattern is the basic pattern for playing conga in salsa music. In the song Necesitas Tu there are two types of variations of the tumbao pattern, namely: variation I and variation II. It can be concluded that the song Necesitas Tu by Blue Mambo has 9 (nine) parts, namely: intro, main theme, development section, interlude, solo, intro, main theme, development section, and coda. The section that has more than one variation of the tumbao rhythm pattern is the development section. Overall there are 4 (four) techniques used in the tumbao pattern such as heel, fingertip/toe, slap, and open tone. The implication of the results of this study is to explore conga instruments that are of interest in developing percussion skills. Music education institutions are to provide adequate facilities so that students are more active in exploring conga instruments, so that students are motivated to improve their abilities or skills in processing Latin percussion instruments as well as Indonesian ethnic percussion.
Successful Long-Term Management of NF1 Congenital Tibial Dysplasia with Prophylactic Bypass Graft and Bracing
Authors: Burgess Regan K. , Crawford Alvin H. , Mehlman Charles T.
Published: October 2024

Case:

An 8-year-old girl with NF1 and congenital tibial dysplasia with significant bilateral tibial bowing underwent McFarland procedures. Now age 22 with 14-year follow-up indicating sustained correction and healing of her bilateral limb deformities.

Conclusion:

This case illustrates the McFarland procedure provided adequate corrective treatment of this deformity and remains a success at long-term follow-up.
POTABILIDADE DA ÁGUA DE POÇOS E OS SERVIÇOS DE ABASTECIMENTO HÍDRICO DA REGIÃO DO MÉDIO SOLIMÕES, AMAZONAS
Authors: Pinho Barbosa Milena , Capeleto de Andrade Leonardo , Rosinski Lima Gomes Maria Cecília
Published: October 2024

As águas subterrâneas têm se tornando a principal fonte de abastecimento hídrico das cidades brasileiras, onde o número real de poços existentes no país torna-se inconclusivo. No estado do Amazonas, apesar da grande disponibilidade de águas dos rios, as cidades preferem utilizar-se das águas subterrâneas. O objetivo do estudo foi avaliar os serviços abastecimento e a potabilidade da água de municípios totalmente abastecidos por águas subterrâneas no Médio Solimões. Foram utilizados banco de dados dos Sistema de Informações de Águas Subterrâneas (SIAGAS) e do Instituto de Proteção Ambiental do Amazonas (IPAAM) e realizadas entrevistas com os gestores dos serviços de abastecimento.  As amostras de água foram coletadas em oito poços de cada município e a análise microbiológica foi desenvolvida pela contagem direta de unidades formadoras de colônias de coliformes totais e Escherichia coli, utilizando o método de filtração por membrana de nitrocelulose. Foram identificados um total de 160 poços nos municípios no sistema do SIAGAS e 14 outorgas concedidas pelo IPAAM. Segundo as entrevistas concedidas, nenhum dos poços operados pelos serviços possuem registros nessas plataformas, encontrando-se irregulares. Em todos os poços analisados houve a presença de coliformes totais e em 75% das amostras houve contaminação por E. coli., estando fora do limite de potabilidade. A deficiência do sistema de abastecimento público faz com que a população se utilize de uma grande quantidade de poços privados irregulares para este suprimento. Todas as amostras foram consideradas não potáveis, em decorrência das concentrações de coliformes totais fora do padrão de potabilidade.
DIREITO À ÁGUA NO CASO NUESTRA TIERRA Vs. ARGENTINA
Authors: Ribeiro dos Santos Allan , Cavalcanti e Silva Filho Erivaldo
Published: October 2024

O presente trabalho foi desenvolvido na área do Direito Internacional Público, abordando o tema do direito à água no caso Nuestra Tierra Vs. Argentina. Neste sentido, buscou-se analisar a evolução da jurisprudência da Corte Interamericana de Direitos Humanos (Corte IDH) desde o início da normatização internacional até a publicação da Opinião Consultiva nº 23/2017, que trouxe novo entendimento à Convenção Americana sobre Direitos Humanos e ao Protocolo de São Salvador. Para o desenvolvimento deste estudo, utilizou-se o tipo de pesquisa exploratória, baseada na revisão normativa, jurisprudencial, bibliográfica e de artigos especializados. Por fim, concluiu-se que um longo caminho foi percorrido até o reconhecimento do direito à água como um direito judicializável e integrante do Corpus Juris internacional de direitos humanos e, embora trate-se de apenas um primeiro julgado, os seus reflexos podem ser observados nos casos que lhe sucederam, como o caso La Oroya Vs. Peru, e ainda, nas discussões que antecedem a publicação da próxima Opinião Consultiva, no contexto das emergências climáticas. Por fim, deve-se reconhecer o papel da Corte IDH como grande efetivadora do direito ao meio ambiente sadio e equilibrado para todos no âmbito regional do Sistema Interamericano de Proteção dos Direitos Humanos que abrange toda a América Latina
WITHDRAWN: The Difference in Fine Motor Performance Between Saudi Boys and Girls in Preschool Age: A Pilot Study
Authors: Alsakhawi Reham , Aleidi Jasmine , Almutairi Renad , Alrifaei Sara , Alnutifi Abeer , Almutiri Rawan
Published: October 2024

The full text of this preprint has been withdrawn by the authors due to author disagreement with the posting of the preprint. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.