bluuebunny/crossref_metadata_2025 huggingface dataset:
LCP1 is a potential prognostic biomarker and correlates with immune infiltration in triple negative breast cancer
Authors: Pan Shuaikang , Wan Mengting , Jin Hongwei , Ning Ran , Zhang Jinguo , Han Xinghua
Published: March 2024

Objective
Triple-Negative Breast Cancer (TNBC), known for its aggressiveness and treatment challenges due to the absence of ER, PR, and HER2 receptors, is the focus of this study. The research emphasizes the need for new biomarkers like LCP1 (Lymphocyte cytosolic protein 1), which plays a crucial role in cell processes and immune cell activity, to predict outcomes and guide treatments in TNBC.
Methods
We explored LCP1's potential as a prognostic biomarker in TNBC, analyzing its mRNA and protein expression levels and their correlation with immune cell infiltration. This involved data from GTEx and TCGA, immunohistochemistry on TNBC and benign tumor samples, and statistical analyses to examine LCP1's relationship with patient clinical characteristics and macrophage markers. We also assessed survival rates, immune cell infiltration, and drug sensitivity related to LCP1 using various bioinformatics tools.
Results
The results indicated that LCP1 expression was significantly higher in TNBC tissues compared to adjacent normal tissues. However, high expression of LCP1 was significantly associated with favorable survival outcomes in patients with TNBC. Enrichment analysis revealed that genes co-expressed with LCP1 were significantly enriched in various immune processes. LCP1 showed a positive correlation with the infiltration of resting dendritic cells, M1 macrophages, and memory CD4 T cells, and a negative correlation with M2 macrophages. Further analysis suggested a link between high levels of LCP1 and increased survival outcomes in cancer patients receiving immunotherapy.
Conclusion
LCP1 shows promise as a diagnostic and prognostic biomarker for improving TNBC treatment strategies.
Cost-benefit analysis of serological and nucleic acid testing for hepatitis B virus in blood donors in southern China
Authors: Ye Xianlin , Xiong Wen , Xu Xiaoxuan , Zeng Jinfeng , Xie He , Li Bin , He Baoren , Chen Limin , Mo Qiuhong
Published: March 2024

Background
Most Chinese blood centers have implemented mini pool (MP) HBV nucleic acid testing (NAT) together with HBsAg ELISA in routine blood donor screening for HBV infection since 2015, and a few centers upgraded MP to individual donation (ID) NAT screening recently, raising urgent need for cost-benefit analysis of different screening strategies. In an effort to prevent transfusion-transmitted infections (TTIs) for HBV, cost-benefit analyses of three different screening strategies: HBsAg alone, HBsAg plus MP NAT and HBsAg plus ID NAT were performed in blood donors from southern China where HBV infection was endemic.
Methods
MP-6 HBV NAT and ID NAT were adopted in parallel to screen blood donors for further comparative analysis. On the basis of screening data and the documented parameters, the number of window period (WP) infection, HBV acute infection, chronic hepatitis B infection (CHB) and occult hepatitis B infection (OBI) was evaluated, and the potential prevented HBV TTIs and benefits of these three strategies were predicted based on cost-benefit analysis by an estimation model.
Results
Of 132,323 donations, the yield rate for HBsAg-/DNA + screened by ID NAT (0.12%) was significantly higher than that by MP NAT (0.058%, P < 0.05). Furthermore, the predicted preventing transfusion transmitted HBV cases was 1.30 times more by ID NAT compared to MP-6 NAT. The cost-benefit ratio of the universal HBsAg screening, HBsAg plus MP NAT and HBsAg plus ID NAT were 1:59.9, 1:28.9 and 1:47.3, respectively.
Conclusions
Universal HBsAg ELISA screening in combination with HBV ID NAT or MP-6 NAT strategies was highly cost effective in China. To further improve blood safety, HBsAg plus HBV DNA ID NAT screening should be considered in HBV endemic regions/countries.
Sex dimorphism of IL-17-secreting peripheral blood mononuclear cells in ankylosing spondylitis based on bioinformatics analysis and machine learning
Authors: Li Sifang , Chao Hua , Li Zihao , Chen Siwen , Zhang Jingyu , Hao Wenjun , Zhang Shuai , Liu Caijun , Liu Hui
Published: March 2024

Background
Ankylosing spondylitis (AS) with radiographic damage is more prevalent in men than in women. IL-17, which is mainly secreted from peripheral blood mononuclear cells (PBMCs), plays an important role in the development of AS. Its expression is different between male and female. However, it is still unclear whether sex dimorphism of IL-17 contribute to sex differences in AS.
Methods
GSE221786, GSE73754, GSE25101, GSE181364 and GSE205812 datasets were collected from the Gene Expression Omnibus (GEO) database. Differential expressed genes (DEGs) were analyzed with the Gene Set Enrichment Analysis (GSEA), Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) methods. CIBERSORTx and EcoTyper algorithms were used for immune infiltration analyses. Machine learning based on the XGBoost algorithm model was used to identify the impact of DEGs. The Connectivity Map (CMAP) database was used as a drug discovery tool for exploring potential drugs based on the DEGs.
Results
According to immune infiltration analyses, mast cells accounted for the largest proportion of IL-17-secreting PBMCs, and KEGG analyses suggested an enhanced activation of mast cells among male AS patients, whereas the expression of TNF was higher in female AS patients. Other signaling pathways, including those involving metastasis-associated 1 family member 3 (MAT3) or proteasome, were found to be more activated in male AS patients. Regarding metabolic patterns, oxidative phosphorylation pathways and lipid oxidation were significantly upregulated in male AS patients. In XGBoost algorithm model, DEGs including METRN and TMC4 played important roles in the disease process. we integrated the CMAP database for systematic analyses of polypharmacology and drug repurposing, which indicated that atorvastatin, famciclocir, ATN-161 and taselisib may be applicable to the treatment of AS
Conclusions
We analyzed the sex dimorphism of IL-17-secreting PBMCs in AS. The results showed that mast cell activation was stronger in males, while the expression of TNF was higher in females. In addition, through machine learning and the CMAP database, we found that genes such as METRN and TMC4 may promote the development of AS, and drugs such as atorvastatin potentially could be used for AS treatment.
Anterior subcutaneous internal fixator (INFIX) versus plate fixation for anterior ring injury in Tile C pelvic fractures: A retrospective study
Authors: Huang Shenbo , He Shuai , Kenmegne Guy Romeo , Yin YiJie , Yu You , Fang Yue
Published: March 2024

Objectives
The purpose of this study was to compare the reduction effect and clinical outcomes of anterior subcutaneous internal fixation (INFIX) and steel plate-screw internal fixation in the treatment of anterior ring injury in Tile C pelvic fractures.
Methods
In this retrospective study, we Compared 46 patients treated using INFIX to 44 patients treated with steel plate and screw internal fixation. All patients underwent anterior and posterior fixation. The Matta imaging scoring system was used to evaluate the postoperative reduction accuracy; the Majeed scoring system was applied to obtain functional outcomes in clinical follow-up. All potential complications were identified and evaluated accordingly.
Results.
Both groups of patients were followed up for a period of 13–36 months, with an average of 27 months. The procedure time and blood loss in the INFIX group were significantly lower than those in the plate group(t = − 2.327, P = 0.023;t = − 4.053, P = 0.000; there was no statistically significant difference in the Majeed score and Matta score between the two groups after surgery (P > 0.05)
Conclusions
INFIX treatment for anterior ring injury in Tile C pelvic fractures can achieve good therapeutic effects. Compared to internal fixation with plates and screws, it has advantages such as shorter surgical time and less blood loss. INFIX may be more suitable for obese patients, young women of childbearing age, or patients with urinary system injuries.
Association between early childhood outdoor activity and anxiety symptoms in preschoolers
Authors: Wu Jian-Bo , Zhang Yan , Yang Yanni , Qiu Shuang-Yan , Zhou Qiang , Li Jiemin , Zhang Jing-Yu , Xian Danxia , Zhou Fang , Zhao Ziyi , Zhang Yuying , Lu Dali
Published: March 2024

Background
Recently, there has been a decreasing trend in the frequency and duration of outdoor activity among children, which has garnered concern regarding the potential impacts of this decline during mental health in early childhood. Currently, the association between outdoor activity in early childhood and the symptoms of anxiety disorders in preschoolers remains unclear. The purpose of this study was to investigated the association between the frequency and duration of outdoor activities in children aged 0-3 yearsand anxiety symptoms in preschoolers.
Methods
A cross-sectional study was conducted in 2021 using questionnaires, included 69,571 preschoolersresiding in Longhua District, Shenzhen. Data on family social demographics, outdoor activity frequency and duration in children aged 0-3 years, and the anxiety symptoms of preschoolerswere collected through parent-completed questionnaires. The association between early childhood outdoor activity and anxiety symptoms in preschoolerswas analyzed using a binary logistic regression model.
Results
Children 0–1 years of age who were outdoors < 1 times/week had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥7 times/week (OR = 2.55, 95% confidence interval(CI): 2.22–2.94). Children in this age group who were outdoors <30 min/session had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥120 min/ session (OR = 1.62, 95%CI: 1.38–1.90). Children 1–3 years of age, who were outdoors < 1 time/week had a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors ≥7 times/week, (OR = 3.10, 95%CI: 2.72–3.54). Children in this age group who were outdoors for < 30 min/sessionhad a higher risk of screening positive for anxiety symptoms in preschool age compared with children who were outdoors time ≥120 min/ session (OR = 2.07, 95%CI: 1.73–2.48).
Conclusion
Lower-frequency and shorter-duration outdoor activity during infancy was associated with a higher risk of anxiety symptoms in preschoolers. A frequency of ≥7 outdoor activity per week and a duration of ≥120 min/session during infancy were associated with lower levels of anxiety symptoms in preschoolers.
Adoption and User Experience of Government of Tanzania-Hospital Management Information System in Meru District Hospital, Arusha, Tanzania: A Qualitative Study
Authors: Edward Lengai , Sukums Felix , Luoga Pankras
Published: March 2024

Background
Electronic medical records (EMRs) have transformed medical information collection, storage, retrieval and use. This led hospitals to invest in EMR adoption and implementation in developed and developing countries. However, EMR implementation is complex, thus calling for assessing the successes of such investment at the various stages of implementation. Therefore, this study aimed to determine the adoption and users’ experience of the Government of Tanzania Hospital Management Information System (GoT-HoMIS) in a primary healthcare facility.
Methodology
A case study employing a qualitative approach was conducted in Meru district hospital in Tanzania. It involved purposive quota sampling of nine hospital managers and healthcare providers. In-depth interviews, observations and document reviews were used. Thematic analysis of qualitative data was used.
Results
The study found that the top-down approach used to adopt GoT-HoMIS limited the preliminary preparations made by the hospital. The availability of a local area network, a reliable electrical power supply, and perceived benefits facilitated the system's use. The use of the system is hindered by partial system implementation, inadequate ICT infrastructure, insufficient ICT knowledge and skills among users, and inadequate management support.
Conclusion
The partial implementation and use of the system in the hospital, inadequate ICT knowledge and skills among users, and insufficient management support in providing funds for ICT infrastructure, training, supervision, and mentorship are the main barriers to effectively using the GoT-HoMIS. Therefore, the study recommended enhancing ICT infrastructure, regular training of users, and strengthening leadership and management support of system implementation.
Reimagining Pathology Reporting for Head and Neck Cancer Resections: 3D Visualizations and Margin Reconciliation
Authors: Yun Jun , Kapustin Danielle , Joseph Justin K. , Su Vivian , Ramirez Ricardo J. , Khan Mohemmed N. , Chai Raymond , Karasick Michael , Wiedmer Christina , Brandwein-Weber Margaret , Urken Mark L.
Published: March 2024

Purpose Surgical pathology reports play an integral role in postoperative management of head and neck cancer patients. Pathology reports of complex head and neck resections must convey critical information to all involved clinicians. Previously, we demonstrated the utility of 3D specimen and defect scanning for communicating margin status and documenting the location of supplemental margins. We introduce a newly-designed permanent pathology report which improves documentation of intraoperative margin mapping and extent of corresponding supplemental margins harvested.Methods A cross-sectional study using human-centered design was implemented to evaluate the existing permanent pathology report with respect to understanding margin status. Pathologists, surgeons, radiation oncologists, and medical oncologists from United States-based medical institutions were surveyed. The results supported a redesign of our surgical pathology template, incorporating 3D specimen / defect scans and annotated radiographic images indicating location of inadequate margins requiring supplemental margins, or indicating frankly positive margins discovered on permanent section.Results Forty-seven physicians completed our survey. Analyzing surgical pathology reports, 28/47 (60%) respondents reported confusion whether re-excised supplemental margins reflected clear margins, 20/47 (43%) reported uncertainty regarding final margin status, and 20/47 (43%) reported the need for clarity regarding the extent of supplemental margins harvested intraoperatively. From this feedback, 61 permanent pathology reports were compiled using newly-designed reporting templates over a 12 month period.Conclusion Feedback from survey respondents led to a redesigned permanent pathology report that offers detailed visual anatomic information regarding intraoperative margin findings and exact location/size of harvested supplemental margins. This reimagined report reconciles frozen and permanent section results and includes annotated radiographic images such that clinicians can discern precise actions taken by surgeons to address inadequate margins.
Pediatric craniopharyngioma with significantly increased intraoperative visual evoked potential amplitude and postoperative visual acuity improvement: a case report
Authors: Oda Yuichi , Amano Kosaku , Chiba Kentaro , Aihara Yasuo , Kawamata Takakazu
Published: March 2024

Visual evoked potential (VEP) is an established modality that allows safe brain tumor resection and preservation of optical function. We herein present a case of a pediatric craniopharyngioma with significant improvement in the VEP amplitude detected during endoscopic transsphenoidal surgery (ETS) and obvious postoperative improvement in visual acuity. A 13-year-old boy presented with visual acuity disturbance in his right eye and was followed-up for 5 months by an ophthalmologist. His visual acuity rapidly worsened, and a suprasellar lesion with calcification was found on brain computed tomography. The patient underwent tumor resection during ETS with intraoperative transcranial VEP monitoring. Gross total tumor resection was achieved without injury to the perforators, including the superior hypophyseal arteries. The VEP amplitude was unstable, and significant waves were not detectable before tumor resection; however, a positive wave was detected after removing most of the tumor and exposing the bilateral optic nerves and optic chiasm. Subsequently, negative and positive VEP waves were continuously detected. Visual acuity improved remarkably on postoperative day 10. This case demonstrated both a significant increase in the intraoperative VEP amplitude and rapid postoperative improvement in visual acuity. We surmised that the preoperative rapid worsening of visual dysfunction, intraoperative increase in the VEP amplitude, and significant postoperative improvement in visual acuity were associated with the compression of the optic nerves by the internal carotid artery, anterior cerebral artery, and tumor.
Effect on Performance, Combustion and Emission Characteristics of Spark Ignition Engine Powered by Premium Level Gasohol- Paraffin Blends With Spark Advancement & Spark Retardment
Authors: Kumbhar Sujit , Khot Sanjay
Published: March 2024

Internal combustion engine emissions from burning fossil fuels, particularly those from petrol engines, are a major factor in change in the climate and the generation of greenhouse gases. For a long time, ethanol has been noticed as a viable alternative to gasoline that might also help to lower pollution levels. In the current experimentation investigations, the engine performance, combustion, and emission characteristics were assessed for the various ethanol-premium gasohol blends with partial addition of alkane’s such as n-pentane, hexane etc. With addition of hexane and n-pentane in premium gasoline and ethanol blends, carbon monoxide (CO) emission decreased by 18% than premium gasohol. The lowest emission were observed for premium gasoline with 40% ethanol and 10% n-pentane. It was observed that addition of hexane and n-pentane hydrocarbons found to be decreased by 15% as compared to premium gasool. Furthermore, with addition of ethanol blending, cylinder pressure decreased. Both unburned hydrocarbon (HC) and Nitrogen oxides (NOx) increased in spark advancement from 21 to 15° bTDC and became minimum for spark timing 21° bTDC. Again, it increased from spark retardment from 21° to 30° bTDC. This was because there was incomplete combustion takes place. But engine emissions decreased with partial addition of alkanes with premium gasoline and 20% ethanol with spark advancement as well as retardment. The brake thermal efficiency of PG + 10% P were found maximum. The oxides of nitrogen (NOx) were found minimum by 25% with addition of ethanol and paraffin in premium gasoline.
Fusion of Two Homoleptic Truncated Tetrahedra into a Heteroleptic Truncated Octahedron
Authors: Zhang Mingming , Liu Haifei , Guo Chenxing , Huang Yujuan , Zhou Zilin , Mu Chaoqun , Zhang Zeyuan , Hou Yali
Published: March 2024

The exploration of novel structures and structural transformation of supramolecular assemblies is of vital importance for their functions and applications. Herein, based on coordination-driven self-assembly, we prepare a neutral truncated tetrahedron and a heteroleptic truncated octahedron, whose structures are unambiguously confirmed by X-ray diffraction analysis. More importantly, the truncated tetrahedron is quantitatively transformed into the truncated octahedron by its fusion with another cationictruncated tetrahedron, as evidenced by fluorescence, mass and NMR spectroscopy. This study not only deepens our understanding of the process of supramolecular fusion but also opens up possibilities for the subsequent preparation of advanced supramolecular assemblies with complex structures and integrated functions.
Association of Patient-Generated Subjective Global Assessment score with surgical outcomes in women with gynecologic cancer
Authors: Jesus Leticia da Silva , Saraiva Danúbia da Cunha Antunes , Marques Bianca Cristina Antunes Alves
Published: March 2024

Objective: To evaluate the association between nutritional status assessed by the Patient-Generated Subjective Global Assessment (PG-SGA) score and surgical complications in patients diagnosed with gynecologic cancer undergoing surgical treatment.
Methods: This was a retrospective study comprising women with gynecologic cancer scheduled for surgical treatment. Nutritional diagnosis was obtained using the PG-SGA, and postoperative outcomes were analyzed, classified, and associated with patients’ nutritional status. For statistical analyses, patients were divided into 2 groups according to PG-SGA score classification. Associations between categorical variables were assessed using the chi-square (χ²) test. Differences in median values of continuous variables were compared using the Mann-Whitney U test. Logistic regression analyses were conducted to determine the likelihood of postoperative complications occurring in patients with higher PG-SGA scores (≥ 4).
Results: The sample consisted of 370 women, with endometrial cancer being the most common cancer. According to PG-SGA, patients with higher scores had longer hospital stays, were more likely to undergo noncurative surgeries, remained in postoperative fasting for a longer duration, and experienced greater postoperative mortality.
Conclusion: Our findings support the use of the PG-SGA as a useful tool for assessing the nutritional status of patients with gynecologic tumors and enabling early intervention in patients at nutritional risk or who are malnourished to optimize nutritional status before surgical intervention and reduce the likelihood of postoperative complications.
The serum metabolome of diffuse axonal injury patients is distinctive and predictive
Authors: Chen Weiliang , Yao Chunyu , Li Shengwen , Chen Rui , Su Wen , Wang Guanjun
Published: March 2024

Background
Metabolism is essential for life maintenance, neurological function and injury repair, yet its role in diffuse axonal injury (DAI) is not fully understood.
Methods
30 DAI patients and 34 non-DAI patients were recruited based on the classification criteria using Magnetic Resonance Imaging (MRI) within 30 days of admission in this exploratory research. Serum samples and clinical parameters were collected upon admission, with the Glasgow Outcome Scale Extended (GOSE) at 6 months post-injury used as the neurological functional outcome. The metabolome was assayed using liquid chromatography-mass spectrometry.
Results
The DAI group and non-DAI group showed significant differences in pupillary light reflex, Glasgow Coma Scale (GCS) score, and Marshall computed tomography (CT) score, as well as in the expression levels of 27 metabolites in serum. Random forest analysis indicated that Lysophosphatidylcholine (LPC) 22:3 sn-2 and carnitine C8:1 greatly contributed to distinguishing DAI patients from non-DAI patients (MeanDecreaseGini: 3.81, 5.16). The combined prediction of DAI using these two metabolites yielded an area under the curve (AUC) of 0.944, which was higher than the combination of clinical parameters.
Conclusions
The serum metabolome of DAI patients is distinctive and has significant value for exploring pathogenesis, determining early diagnosis, and improving long-term neurological function.
Visualization and Bibliometric Analysis of Extracellular Vesicles in Cartilage Regeneration from 2013 to 2023
Authors: Jia Shicheng , Gao Tianze , Zhang Ruiyang , Chen Jiayou , Liang Rongji , Ren Yuxiang , Jiang Xiaocheng , Lin Jianjing
Published: March 2024

Purpose: This study aims to elucidate emerging trends, dynamic advancements, and research focal points in exosome-mediated repair and regeneration of cartilage damage over the past decade, employing a visualization approach.
Methods: A total of 300 research records focusing on the utilization of exosomes in cartilage damage repair and regeneration were systematically gathered from the Web of Science Core Collection (WoSCC) database spanning the years 2013 to 2023. Utilizing R language, VOSviewer, CiteSpace, and GraphpadPrism software, we conducted analyses on the general features, historical progression, literature, and keywords of this research domain. Ultimately, we predicted the research focal points and latest trends in the application of exosomes for cartilage defect repair and regeneration.
Results: The study amassed a total of 300 articles, revealing a steady increase in publications on exosome application in cartilage repair and regeneration over the years. Significantly, contributions from researchers in China, the USA, and Italy have been pivotal in shaping this field. Keywords clustered into nine distinct research subareas, encompassing mesenchymal stem cells (MSCs), osteochondral repair, runx2, drug delivery, mesenchymal stromal cells, unconventional secretion, biological membranes, and regenerative medicine. Notably, keywords such as "osteochondral repair," "runx2," and "drug delivery" featured prominently between 2013 and 2023.
Conclusion: Through a comprehensive review of 300 publications, this bibliometric study provides a detailed overview of exosome-related research in cartilage damage repair and regeneration from 2013 to 2023. The findings contribute to the construction of a knowledge map, illustrating the evolving landscape in this domain. Identifying current trends and potential hotspots, this study offers valuable insights for future researchers in the field.
Design, synthesis and bioactivity evaluation of novel monomethyl auristatin F analogues
Authors: Yang Lisheng , Li Xinglin , Zhao Lei , Hu Wenhao , Qian Yu
Published: March 2024

Monomethyl auristatin F (MMAF), a synthetic analogue of the natural compound dolastatin 10, has garnered significant attention in cancer research due to its high potency in vitro. While previous studies have focused on modifying the N-terminal extension of the amino group and the C-terminal modification of the carboxyl group, there has been limited exploration into modifying the P1 and P5 side chains. In this study, we substituted the valine residue at the P1 position with various natural or unnatural amino acids and introduced triazole functional groups at the P5 side chain. Compounds 11k and 18d exhibited excellent inhibition on tubulin. Additionally, compound 18d demonstrated enhanced cytotoxicity against HCT116 cells compared to the parent compound MMAF, suggesting its potential as a cytotoxic payload for further antibody-drug conjugates (ADC) development.
Evolving Digital Skills of first-year students: A Pre- and Post-Covid Analysis
Authors: Ebner Martin , Mair Bettina , Nagler Walther , Schön Sandra , Edelsbrunner Sarah
Published: March 2024

Digital skills are necessary for first-year students at Austrian universities. This paper unveils results from two surveys among first-year students at Graz University of Technology (TU Graz): Pre-Covid-19 data (n=921) is derived from a larger study on digital literacy among first-year students in Styria (Janschitz et al., 2021, N=4,676). The same questions were posed in the 2021 ‘Welcome Days’ survey after the Covid-19 distance learning phases (n=1,207). Surprisingly, the only significant change is a noticeable increase of skills concerning the digital signature. This article additionally presents the development of a lecture on digital skills that was implemented at TU Graz as a massive open online course (MOOC).
The risks of symbiotic relationship between terrorism and the media in media coverage of russia’s military aggression against Ukraine
Authors: Myslovskyi Ihor
Published: March 2024

Introduction. The symbiotic relationship between terrorism and the media may have destructive media effects on society in peacetime, but under wartime conditions, these effects may intensify, pose new threats, and weaken the state’s position in fighting against the enemy.
Relevance of the study. Identifying and analyzing these risks is a critical and relevant topic and scientific task during Russia's military aggression against Ukraine, which has significantly scaled after Russia invaded Ukraine in 2022. Therefore, the purpose of the article is to analyze the risks of the symbiotic relationship between terrorism and the media in the coverage of Russia's aggression by Ukrainian journalists.
Methodology. The negative consequences of the symbiotic relationship between terrorism and the media are identified through the analysis of scientific and media criticism articles. The risks of such ties during Russia’s military aggression against Ukraine were determined by induction, reasoning by analogy, ascent from the abstract to the concrete, synthesis, and generalization.
Results. The disproportionate to the overall war threat, overly dramatic and sensitive, sensationalized, detailed coverage of Russia’s terrorist practices in the Ukrainian media can lead to destructive media influence desired by the enemy: spreading fear, panic and paralyzing pessimism among Ukrainians, which turn them into a dysfunctional, disorganized society incapable of mobilizing resources under existential threats; such a society usually makes more significant emotional, irrational political pressure on the authorities making concede to terrorists; polarization of public opinion and internal political destabilization; Ukrainians who are latent supporters of Russia may perceive massive terrorist attacks as a manifestation of Russian tremendous military capability and a call to action (risks of collaboration and sabotage); distraction of public attention from other problems, such as losses on the battlefield; obtaining information from the media about the psychological state of society, countermeasures of the security forces (OSINT intelligence), etc.
Conclusions. When covering Russia’s military aggression against Ukraine, Ukrainian journalists need to weaken the symbiotic relationship between terrorism and the media. They should develop a media frame for covering the Russian Federation’s terror that provides objective and comprehensive information for citizens and does not cause long-term destructive media effects on Ukrainian society, as well as indirect assistance to the enemy. Ukrainian media professionals can use the article’s results and journalistic examples to formulate or improve their editorial policy on media coverage of Russia’s terror in Ukraine.
Thermal equation of state of Li-rich schorl up to 15.5 GPa and 673 K: Implications for lithium and boron transport in slab subduction
Authors: Chen Wei , Zhang Shanrong , Wu Mengzeng , Zhong Qifa , Huang Shijie , Wang Kai , Zhao Wei , Xu Jingui , Fan Dawei , Zhou Wenge
Published: March 2024

The thermal equation of state (EoS) of a natural schorl has been determined at high temperatures up to 673 K and high pressures up to 15.5 GPa using in situ synchrotron X-ray diffraction combined with a diamond-anvil cell. The pressure-volume (P-V) data were fitted to a third-order Birch-Murnaghan EoS with V0 = 1581.45 ± 0.25 Å3, K0 = 111.6 ± 0.9 GPa, and K0′ = 4.4 ± 0.2; additionally, when K0′ was fixed at a value of 4, V0 = 1581.04 ± 0.20 Å3, and K0 = 113.6 ± 0.3 GPa. The V0 (1581.45 ± 0.25 Å3) obtained by the third-order Birch-Murnaghan EoS agrees well with the V0 (1581.45 ± 0.05 Å3) measured at ambient conditions. Furthermore, the axial compression data of schorl at room temperature were fitted to a “linearized” third-order Birch-Murnaghan EoS, and the obtained axial moduli for the a- and c-axes are Ka = 621 ± 9 GPa and Kc = 174 ± 2 GPa, respectively. Consequently, the axial compressibilities are βa = 1.61 × 10–3 GPa–1 and βc = 5.75 × 10–3 GPa–1 with an anisotropic ratio of βa:βc = 0.28:1.00, indicating axial compression anisotropy. In addition, the compositional effect on the axial compressibilities of tourmalines was discussed. Fitting our pressure-volume-temperature (P-V-T) data to a high-temperature third-order Birch-Murnaghan EoS yielded the following thermal EoS parameters: V0 = 1581.2 ± 0.2 Å3, K0 = 110.5 ± 0.6 GPa, K0′ = 4.6 ± 0.2, (∂KT/∂T)P = –0.012 ± 0.003 GPa K–1 and αV0 = (2.4 ± 0.2) × 10–5 K–1. These parameters were compared with those of previous studies on other tourmalines, and the potential factors influencing the thermal EoS parameters of tourmalines were further discussed.
Impact of warning labels on sugary beverages on risk perception, attention, and purchase intentions
Authors: Novrianda Herry , Muttaqin Faisal , Shar Aan
Published: March 2024

The issue of warning labels on sweet beverage product packaging needs to be tested to determine its role in reducing product consumption. This study aims to examine the impact of warning labels on attention, risk perception, and purchase intention for sweet drink products. The paper conducted an experiment involving 120 participants. Most respondents fall within the age range of 25 to 34 years (38.30%). The analysis was conducted at sports facilities, schools, and playgrounds – in three major cities in Indonesia (Jakarta, Bandung and Surabaya). Two stimuli, sugar content labels and visual warning labels, were used after a pilot study. For data analysis, the study used univariate analysis of variance to assess the significance of each label stimulus interaction. Furthermore, this paper employed t-tests to check the significance of comparisons between cells. Through the difference test, the three hypotheses were accepted and had a significant effect. The findings reveal that the influence of visual warning labels on attention (t-value = 66.015), perceived risk (t-value = 68.064), and purchase intention (t-value = 60.483) is more significant than sugar content labels. These findings can serve as a set of innovative policies to support the success of demarketing strategies for sweet beverage products by governments and social marketing activists.
Quality of life of patients with an advanced stage of proliferative diabetic retinopathy after application of various vitrectomy technologies
Authors: Teshev A. F. , Malyshev A. V.
Published: March 2024

Purpose: A comparative assessment of quality of life (QL) after the use of various vitrectomy (VE) technologies in patients with an advanced stage of proliferative diabetic retinopathy (ASPDR).

Material and methods. We examined 132 patients aged 42 to 76 (average age 62.8 ± 2.4 years) who met the classification criteria of ASPDR: impossibility to estimate the area of neovascularization; the fundus of the eye in the posterior pole cannot be seen or can only partialy be seen using an ophthalmoscope; evidence of preretinal or vitreal hemorrhage in the posterior pole with an area of more than 4 optic discs and retinoschisis in the macular zone. All patients were divided into two groups, comparable in age, gender and visual status of the “healthy” eye: the main group (69 eyes), in which VE was performed according to the technique developed by the authors, and the control (63 eyes), in which the traditional VE technique was used. QL was assessed before surgery and 3 months after it using the VFQ-25 and QL-20 questionnaires.

Results. QL was found to be higher when the new surgery technique was used: the data of VFA-25 showed a 12.9% increase (p < 0.05) and QL-20 showed a 29.2% increase (p < 0.01), which points to a higher clinical effectiveness of the newly developed surgical treatment technique than that of the traditional technique.

Conclusion. The results obtained are related to the ophthalmological features of the developed surgical treatment of ASPDR: combined (phacoemulsification of cataracts + IOL + vitrectomy) one-stage intervention, lack of drainage of subretinal fluid, etc.), medication support (preliminary intravitreal administration of an angiogenesis inhibitor) and anesthesia (intervention under local anesthesia with intravenous sedation). The differences are most effectively identified using the special QL-20 questionnaire.
Improving the daily pan evaporation estimation of long short-term memory and support vector regression models by using the Wild Horse Optimizer algorithm
Authors: Shabani Mohammad , Asadi Mohammad Ali , Fathian Hossein
Published: March 2024

Evaporation is a basic element in the hydrological cycle that plays a vital role in a region's water balance. In this paper, the Wild Horse Optimizer (WHO) algorithm was used to optimize long short-term memory (LSTM) and support vector regression (SVR) to estimate daily pan evaporation (Ep). Primary meteorological variables including minimum temperature (Tmin), maximum temperature (Tmax), sunshine hours (SSH), relative humidity (RH), and wind speed (WS) were collected from two synoptic meteorological stations with different climates which are situated in Fars province, Iran. One of the stations is located in Larestan city with a hot desert climate and the other is in Abadeh city with a cold dry climate. The partial mutual information (PMI) algorithm was utilized to identify the efficient input variables (EIVs) on Ep. The results of the PMI algorithm proved that the Tmax, Tmin, and RH for Larestan station and also the Tmax, Tmin, and SSH for Abadeh station are the EIVs on Ep. The results showed the LSTM–WHO hybrid model for both stations can ameliorate the daily Ep estimation and it can also reduce the estimation error. Therefore, the LSTM–WHO hybrid model was proposed as a powerful model compared to standalone models in estimating daily Ep.
Determination of seawater COD spectra using double-loop contraction and sorted frog optimization
Authors: Hou Shiwei , Zhang Yingying , Yuan Da , Feng Xiandong , Zhang Ying
Published: March 2024

This study develops a novel double-loop contraction and C value sorting selection-based shrinkage frog-leaping algorithm (double-contractive cognitive random field [DC-CRF]) to mitigate the interference of complex salts and ions in seawater on the ultraviolet–visible (UV–Vis) absorbance spectra for chemical oxygen demand (COD) quantification. The key innovations of DC-CRF are introducing variable importance evaluation via C value to guide wavelength selection and accelerate convergence; a double-loop structure integrating random frog (RF) leaping and contraction attenuation to dynamically balance convergence speed and efficiency. Utilizing seawater samples from Jiaozhou Bay, DC-CRF-partial least squares regression (PLSR) reduced the input variables by 97.5% after 1,600 iterations relative to full-spectrum PLSR, RF-PLSR, and CRF-PLSR. It achieved a test R2 of 0.943 and root mean square error of 1.603, markedly improving prediction accuracy and efficiency. This work demonstrates the efficacy of DC-CRF-PLSR in enhancing UV–Vis spectroscopy for rapid COD analysis in intricate seawater matrices, providing an efficient solution for optimizing seawater spectra.
Defining the Notion ‘Youth Entrepreneurship’ in View of Including in it Specific Features of Entrepreneurial Resource Use
Authors: Shpileva A. A.
Published: March 2024

The article studies possible definitions of the notion ‘youth entrepreneurship’ with regard to including in it specific features of entrepreneurial resource use, such as generation of business ideas (initiatives), implementation of business-projects and management of their realization. The author proposed to summarize definitions that take into account both age characteristics of young people and level of their education and features of entrepreneurial resource realization, such as entrepreneurial capital, skills, knowledge, motivation and innovation abilities. Within the frames of the article the model of education lever was put forward and discussed that shows the impact of state support tools being realized in state education policy on the development of youth entrepreneurship. The research findings can be useful for investigators, practical workers and state bodies dealing with the development of youth entrepreneurship.
Problems of Human Development Differentiation in Russian Regions
Authors: Kononenko K. O.
Published: March 2024

The Russian Federation is the biggest country in the world, which consists of 89 entities. Vast territory, a lot of nationalities and confessions, different climate and mentality create conditions for differentiation in the standard of living of people. In present circumstances unevenness is typical of the development of social and economic systems in countries and in persons. Economy of the 6th technological structure is characterized by high degree of automation and advanced technologies, which gives an opportunity to raise labour productivity and cut costs. However, not all regions can adapt to new requirements of this economic model. In this economy it is necessary both to modernize equipment and technology and constantly develop human labour resource. According to the Maslow pyramid, the standard of life means the degree of population needs satisfaction. The standard of life of the population in the country is connected with people prosperity, accumulation of human capital and the level of human development. In Russia and in the whole world the problem of the population standard of life became drastic during the global finance crisis 2008–2010 and COVID-19 pandemic. The UN in 2020 prepared the rating of countries by standard of life based on the Human Development Index. Today it is quite clear that human potential is becoming the main indicator of social and economic development of mankind. Human potential is a sum total of opportunities, capabilities and resources that each person possesses for self-development, attaining his/her goals and valuable participation in society. It includes intellectual, creative, physical, emotional and social abilities, as well as knowledge, skills and experience, that person can use to resolve problems and overcome difficulties. Human potential is inexhaustible and it can be developed and realized during the whole life. The authors identified problems of shaping and developing human capital in regions of the Russian Federation: ecological and climatic factors, differentiation in income level and quality of education programs. As a result of the analysis a project approach to resolving these problems was proposed.
Dynamic Approach to the Development of Basic Management Tools in Processes of Strategic Management
Authors: Kamionsky M. S.
Published: March 2024

The article provides results of methodological research dealing with dynamics of basic management tool development used in strategic management. These tools used for elaborating strategy of companies in different industries proved their practical usefulness and caused no doubt in the necessity of their use for many decades. However, objective changes in the world, including the sphere of strategic management have led to the need to revise a number of key methods and tools of management used for strategy elaboration. Extreme complexity of today’s world results in diversity of approaches and tools for shaping and realizing strategies. The author substantiated the necessity of this revision and described outdated components of the SWOT-analysis, the method of management by goals, SMART criteria in goal-setting, development of business-processes, forecasting and some other methods. Serious changes in using these methods in advanced companies were discussed and necessary upgrading connected with growing dynamic and controversy of processes in internal and external environment was highlighted. The use of renewed management tools in strategic management can allow us to get serious results both in strategy elaboration and in its actualization and realization in practice.
Procedury stosowane u noworodka urodzonego przedwcześnie w oparciu o standard organizacyjny opieki okołoporodowej
Authors: Sak Paulina
Published: March 2024

Wstęp. Wcześniak to noworodek, który pojawił się na świecie zdecydowanie za szybko, a faza rozwoju w której się znajduje, nie jest jeszcze czasem, kiedy powinien przebywać w naturalnym środowisku. Dzieci te, zaraz po urodzeniu, jak i podczas swojego, czasami długiego pobytu w szpitalu mają wykonywane wiele procedur medycznych. Obecny standard organizacyjny opieki okołoporodowej uzasadnia wykonywanie tych procedur. Aby wykonać procedurę medyczną należy uzyskać świadomą zgodę matki. Ważnym aspektem jest edukacja matek, które urodziły przedwcześnie, ma ona na celu poznanie i zaakceptowanie wszystkich procedur. Prawidłowo przeprowadzona edukacja pozwana na zwiększenie wiedzy matki wcześniaka i podjęcie świadomej decyzji na wykonanie procedur medycznych.

Cel pracy. Celem niniejszej pracy jest analiza realizacji procedur medycznych wykonywanych u noworodka urodzonego przedwcześnie w ramach standardu organizacyjnego opieki okołoporodowej.

Materiał i metody. Materiał badawczy obejmuje 103 kobiety, które są matkami noworodków urodzonych przedwcześnie w WSS we Włocławku, w oddziale neonatologicznym. W pracy wykorzystano autorski kwestionariusz ankiety niezbędny do przeprowadzenia badań, skalę Apgar i arkusz danych o wcześniaku.

Wyniki. Procedury takie, jak: odpępnienie, skala Apgar, oznakowanie, witamina K., szczepienie WZW, testy słuchu, testy suchej bibuły, test pulsoksymetryczny zostały wykonane u wszystkich dzieci, zaś w najmniejszym stopni HBS i skala Silvermana. Personel medyczny realizuje wszystkie wymagane procedury w ramach standardu organizacji opieki okołoporodowej wobec noworodka urodzonego przedwcześnie u większości (niemal 100%). Czynniki socjodemograficzne takie, jak wiek, miejsce zamieszkania, wykształcenie mają wpływ na poziom wiedzy matek o procedurach medycznych wykonywanych u wcześniaka. Matki noworodków urodzonych przedwcześnie są usatysfakcjonowane poziomem edukacji na temat wykonywanych u ich dzieci procedur medycznych.

Wnioski. Procedury medyczne w oparciu o standard organizacyjny zostały wykonane u większości dzieci, dowodzi to o wysokiej jakości opieki świadczonej przez personel medyczny.
Solution-focused brief counseling in reducing the negative impact of problematic online game use
Authors: Mulawarman Mulawarman , Hariyadi Sigit , Nugraheni Edwindha Prafitra , Antika Eni Rindi , Soputan Shania Dea Menany
Published: March 2024

The study purposed to examine the effectiveness of the solution-focused brief counseling (SFBC) intervention to reduce the negative impacts of problematic online games use (POGU) in college students. The research subjects were chosen by purposive sampling method of students who have problems with online games at the Universitas Negeri Semarang (UNNES). The study was conducted with an embedded experimental research design in which the data was obtained using a quantitative approach. POGU and online addiction games were included in the characteristics of people with internet addiction (IA) based on the diagnostic and statistical manual of mental disorders, fourth edition (DSM-IV) criteria that have a negative impact. Based on the study, negative effects of playing online games included low self-control, not being able to reduce the length of time playing online games and having thoughts (preoccupation cognitive) that could not be controlled and weakening the brain work systems causing the online game addicts. The form of intervention used in the study was SFBC. The SFBC stages carried out included building relationships, identifying complaints that could be resolved, setting goals, designing, and implementing interventions, termination, evaluation, and follow-up.