bluuebunny/crossref_metadata_2025 huggingface dataset:
Snapshot of ultrasound imaging in basic anatomy and physiology teaching in the United Kingdom and Republic of Ireland: perceptions, obstacles, and solutions
Authors: Graham Emma C. , Sweeney Eva M. , Johnson Christopher D.
Published: September 2022

We surveyed UK and Republic of Ireland institutions to establish the extent of ultrasound use in teaching undergraduate modules with significant anatomy or physiology content. Responses indicate that although ultrasound is used for a wide variety of systems, only a small proportion of courses use ultrasound for teaching. There is widespread interest in its use, with the main barriers being unfamiliarity with potential uses and the technology. We endorse further dissemination of this teaching practice.
The hypoxia-inducible factor-α prolyl hydroxylase inhibitor FG4592 ameliorates renal fibrosis by inducing the H3K9 demethylase JMJD1A
Authors: Ike Takeshi , Doi Shigehiro , Nakashima Ayumu , Sasaki Kensuke , Ishiuchi Naoki , Asano Tomoichiro , Masaki Takao
Published: September 2022

Using a mouse model of renal fibrosis and transforming growth factor-β1-stimulated rat cell lines, we show that treatment with FG4592, an inhibitor of hypoxia-inducible factor-1α and -2α (HIF-1α/2α) prolyl hydroxylase decreases renal fibrosis and concomitantly reduces methylated lysine 9 of histone H3 (H3K9) levels via upregulation of Jumonji domain-containing 1a (JMJD1A). The results identify a novel role for the HIF-1α/2α-JMJD1A-H3K9 regulatory axis in suppressing renal fibrosis.
Potential of soluble (pro)renin receptor in kidney disease: can it go beyond a biomarker?
Authors: Yang Tianxin
Published: September 2022

(Pro)renin receptor (PRR), also termed ATPase H+-transporting accessory protein 2 (ATP6AP2), is a type I transmembrane receptor and is capable of binding and activating prorenin and renin. Apart from its association with the renin-angiotensin system, PRR has been implicated in diverse developmental, physiological, and pathophysiological processes. Within the kidney, PRR is predominantly expressed in the distal nephron, particularly the intercalated cells, and activation of renal PRR contributes to renal injury in various rodent models of chronic kidney disease. Moreover, recent evidence demonstrates that PRR is primarily cleaved by site-1 protease to produce 28-kDa soluble PRR (sPRR). sPRR seems to mediate most of the known pathophysiological functions of renal PRR through modulating the activity of the intrarenal renin-angiotensin system and provoking proinflammatory and profibrotic responses. Not only does sPRR activate renin, but it also directly binds and activates the angiotensin II type 1 receptor. This review summarizes recent advances in understanding the roles and mechanisms of sPRR in the context of renal pathophysiology.
Myosin Heavy Chain as a Novel Key Modulator of Striated Muscle Resting State
Authors: Lewis Christopher T. A. , Ochala Julien
Published: September 2022

After years of intense research using structural, biological, and biochemical experimental procedures, it is clear that myosin molecules are essential for striated muscle contraction. However, this is just the tip of the iceberg of their function. Interestingly, it has been shown recently that these molecules (especially myosin heavy chains) are also crucial for cardiac and skeletal muscle resting state. In the present review, we first overview myosin heavy chain biochemical states and how they influence the consumption of ATP. We then detail how neighboring partner proteins including myosin light chains and myosin binding protein C intervene in such processes, modulating the ATP demand in health and disease. Finally, we present current experimental drugs targeting myosin ATP consumption and how they can treat muscle diseases.
Individual Online Learning Behavior Analysis Based on Hadoop
Authors: Xiang Ning
Published: September 2022

The online individual behavior analysis is an important means for mining user interests. The user retweeting behavior prediction is typical problem for online individual behavior analysis. In order to make online learning behavior prediction method more suitable for the application of large-scale datasets, the improved condensed K nearest neighbor (ICKNN) method is proposed in this paper. Inspired by the idea of compressing samples in the condensed nearest neighbor (CNN) algorithm, this proposed method has adopted the Hadoop platform to parallelize the traditional CNN algorithm. For the traditional CNN method, as the value of K increases, the compression ratio decreases and so as the efficiency. The proposed ICKNN method can parallelize the traditional CNN method under the Hadoop framework to enhance efficiency. The proposed ICKNN method in this paper is validated by actual Twitter retweeting dataset. It can be seen that the proposed method in this paper has a higher compression rate than the traditional CNN algorithm. In terms of accuracy, the classification accuracy of the proposed ICKNN method has decreased compared with the traditional KNN method. However, the time consumed by the ICKNN method has significantly reduced compared with the traditional KNN method and CNN method, which can greatly improve the efficiency.
[Retracted] Data Analysis of College English Speculative Reading Teaching Based on Multimodal Teaching Theory in a Complex Cross‐Cultural Environment
Authors: Jiang Tiantian
Published: September 2022

With the continuous rise of my country’s international status, the cultivation of students’ cross‐cultural thinking ability has become an important goal of college English teaching. Since the twentieth century, theories about critical thinking ability have been abundant, and how to improve students’ critical thinking ability is also a hotspot of reform. In foreign countries, there are rich teaching models, but in China, it is still a major problem to be solved to cultivate students’ speculative ability through specific teaching methods. How teachers’ classroom teaching is related to the cultivation of speculative ability. In addition to having direct application significance for teachers to realize the cultivation of speculative ability in routine teaching, the research on these issues is conducive to opening the “black box” of classroom instruction. The most crucial tasks in teaching speculative reading and cross‐cultural education in today’s college English curriculum are the only means of enhancing students’ critical thinking and cross‐cultural communication skills. This paper analyses, researches, and applies the diagnostic evaluation model using data gathered during system usage. In order to enhance the diagnostic evaluation function of the college English diagnostic practice system and the associated test paper generation algorithm, the author then designs and implements two test recommendation algorithms in accordance with the diagnostic evaluation model.
Comparison between Percutaneous Kyphoplasty and Posterior Fixation Combined with Vertebroplasty in the Treatment of Stage III Kümmell’s Disease without Neurological Deficit
Authors: Liu Yijie , Zhu Yi , Li Renjie , Jiang Weimin , Yang Huilin
Published: September 2022

Objective. To evaluate the clinical and radiological outcomes of percutaneous kyphoplasty (PKP) versus posterior fixation combined with vertebroplasty PF+VP for treating stage III Kümmell’s disease (KD) patients without neurological deficits. Methods. From April 2016 to February 2020, a total of 88 patients with single‐level stage III KD without neurological deficits, including 45 patients treated by PKP and 43 patients who underwent posterior fixation combined with vertebroplasty PF+VP, were retrospectively studied. The outcome parameters, including blood loss, operative time, kyphotic Cobb angle, height of vertebrae, Oswestry Disability Index (ODI), and visual analog scale (VAS) score, were compared between the PKP group and the PF+VP group. Results. The mean follow‐up time was 29.3 ± 7.0 months, ranging from 24 to 48 months. The kyphotic angle and vertebral height in both groups were significantly improved compared with those before surgery at three days, 3 months and the final follow‐up. The estimated blood loss, operative time, and length of stay were significantly lower in the PKP group than in the PF+VP group (P < 0.001). The FP+VP group showed better results in kyphotic angle correction than the PKP group (P = 0.024). In the short‐term follow‐up (up to 3 months), the PKP group had lower VAS and ODI scores than the PF+VP group. In contrast, there were no significant differences between the two groups (P > 0.05) at the final follow‐up. The average cost of PKP was lower than that of PF+VP. Conclusion. The results of our study showed that both PKP and PF+VP were safe and effective for stage III KD patients without neurological deficits. Although PF+VP presents better performance in kyphotic angle correction, PKP was associated with less surgical trauma, quicker pain relief, and lower expense than PF+VP. Therefore, it can be considered an alternative option for patients with advanced KD.
Candesartan Reduces Neuronal Apoptosis Caused by Ischemic Stroke via Regulating the FFAR1/ITGA4 Pathway
Authors: Ding Yubao , Lang Yue , Zhang Hui , Li Yu , Liu Xiao , Li Minjie
Published: September 2022

Ischemic stroke (IS) is a general term for necrosis of brain tissue caused by stenosis, occlusion of arteries supplying blood to the brain (carotid artery and vertebral artery), and insufficient blood supply to the brain. Cerebral ischemia is the main kind of IS causing cell damage. However, the underlying mechanism still needs to be clarified further. In this study, it was demonstrated that FFAR1 was a hub gene in IS. The expression of FFAR1 was increased in PC12 cells with OGD/R treatment. FFAR1 deficiency inhibited cell viability and induced cell apoptosis, which was reversed by FFAR1 overexpression. Moreover, candesartan, as a compound targeting FFAR1, facilitated cell viability and reduced cell apoptosis. The expression of ITGA4 was also high in OGD/R-PC12 cells as FFAR1. Furthermore, FFAR1 deficiency retarded the increasing of cell viability and inhibition of cell apoptosis by downregulation of Bax and Cleaved Caspase-3 in OGD/R-PC12 cells with candesartan treatment. In conclusion, candesartan may regulate neuronal apoptosis through FFAR1/ITGA4 axis.
Profiling Serum Cytokines and Anticytokine Antibodies in Psoriasis Patients
Authors: Hong Dan , Liu Xiuting , Qiu Xiaonan , Lu Siyao , Jiang Yanyun , Tan Guozhen , Shi Zhenrui , Wang Liangchun
Published: September 2022

Cytokines like IL-17A have been consistently found to be elevated in psoriatic lesional skin, and therapeutic antibodies to IL-17 have demonstrated efficacy in treating psoriatic skin and joint disease. However, results about the circulating cytokines in psoriasis patients remained controversial. Anticytokine autoantibodies (ACAAs) were detected in various autoimmune diseases but remained largely unknown in psoriasis. We aimed to investigate the serum levels of cytokines and ACAAs in psoriasis patients. The study included 44 biologics-naive psoriasis patients and 40 healthy controls. Serum cytokines and the corresponding autoantibodies were measured by multiplex bead-based technology. The bioactivity of serum IL-17A was determined by IL-8 production in primary keratinocytes. Herein, we found serum levels of IL-12B (median: 6.16 vs. 9.03,

p
=
0.0194

) and Th17 cytokines (IL-17A: median: 0.32 vs. 1.05,

p
=
0.0026

; IL-22: median: 4.41 vs. 4.41,

p
=
0.0120

) were increased in psoriasis patients. More interestingly, bioactive IL-17A was identified in a proportion of patients and positively correlated with disease severity. A few of cytokines were closely associated with each other and formed into a distinct panel in psoriasis. Of 13 anticytokine antibodies, anti-IL-22 was moderately lower (median: 262.8 vs.190.5,

p
=
0.0418

), and anti-IL-15 was slightly higher (median: 25.5 vs. 30.5,

p
=
0.0069

) in psoriasis than controls. None of ACAAs was related to disease severity. Consequently, the ratios of antibodies to cytokines varied with the pattern of cytokines. In summary, our finding suggested that the levels of circulating bioactive IL-17A were associated with disease activity in psoriasis patients. In contrast, the titers of ACAAs were not significantly altered nor correlated with disease severity. However, the functionality of ACAAs remains to be further demonstrated in vitro in future studies.
Establishment and Identification of Patient-Derived Xenograft Model for Oral Squamous Cell Carcinoma
Authors: He Fei , Zhou Xiongming , Huang Gan , Jiang Qingkun , Wan Li , Qiu Jiaxuan
Published: September 2022

Oral squamous cell carcinoma is the most common head and neck malignancy with high morbidity and mortality. Currently, platinum-based chemotherapy is the conventional chemotherapy regimen for patients with oral squamous cell carcinoma. However, due to the heterogeneity of tumors and individual differences of patients, chemotherapy regimens lacking individualized evaluation of tumor patients are often less effective. Therefore, personalized tumor chemotherapy is one of the effective methods for the future treatment of malignant tumors. The patient-derived xenograft model is a relatively new tumor xenograft model that relies on immunodeficient mice. This model can better maintain various histological characteristics of primary tumor grafts, such as pathological structural features, molecular diversity, and gene expression profiles. Therefore, the patient-derived xenograft model combined with drug screening technology to explore new tumor chemotherapy is the critical research direction for future tumor treatment. This study successfully established the patient-derived xenograft model of oral squamous cell carcinoma. It was verified by hematoxylin-eosin staining and immunohistochemistry that the constructed patient-derived xenograft model retained the pathological and molecular biological characteristics of primary tumors. Our patient-derived xenograft model can be used further to study the oncological characteristics of oral squamous carcinoma and can also be applied to personalize the treatment of oral squamous carcinoma patients, providing a practical resource for screening chemotherapy drugs.
Relationship between Craniovertebral Abnormalities and Maxillary Lateral Incisors Agenesis: A Case-Control Study
Authors: Sobouti Farhad , Aryana Mehdi , Ghadiri Seyed Mohammad , Modanloo Kiarash , Dadgar Sepideh
Published: September 2022

Objectives. This study aimed to investigate whether the sella turcica bridging (STB) and ponticulus posticous (PP) are associated with the congenital missing maxillary lateral incisor (CMMLI), based on lateral cephalograms of patients who needed orthodontic treatment. Materials and Methods. This case-control study examined 160 panoramic images and lateral cephalograms of 2000 patients seeking orthodontic treatment. The case group included 80 patients with CMMLI (40 with unilateral and 40 with bilateral CMMLI) and the control group included 80 patients without CMMLI. Panoramic images were used to diagnose CMMLI and lateral cephalograms showed STB and PP extension. The researchers used statistical analyses to examine the relationship among STB, PP, and CMMLI (

P
<
0.05

). Results. The prevalence of STB type I, II, and III was 47.5%, 35%, and 17.5% in the case group and 72.5%, 22.5%, and 5% in the control group, respectively, determining a positive relationship between CMMLI and STB and a significant relationship between bilateral CMMLI and STB (

P
<
0.05

for both). The prevalence of normal, incomplete, and complete PP extension was 80%, 5%, and 15% in the case group and 82.5%, 5%, and 12.5% in the control group, respectively. There was no significant relationship between CMMLI and PP extension (

P
>
0.05

) and between the STB and the PP extension (

P
>
0.05

). Conclusion. CMMLI was significantly related to STB but not to PP extension. Investigating the relationship between unilateral/bilateral CMMLI, STB, and PP has shown only a significant relationship between bilateral CMMLI and STB. There was no significant relationship between STB and PP extension.
Study on the Potential Mechanism of miR-22-5p in Non-Small-Cell Lung Cancer
Authors: Han Xuemei , Li Hua , Liu Shuhui , Zhao Zhiqiang
Published: September 2022

Objective. Non-small-cell lung cancer (NSCLC) ranks among one of the most lethal malignancies worldwide. A better and comprehensive understanding of the mechanism of its malignant progression will be helpful for clinical treating NSCLC. Methods. The miRNA expression profiles and target gene profiles downloaded from the Gene Expression Omnibus and TargetScan databases were used to identify the key regulatory pattern in NSCLC by bioinformatic analysis. The regulation of miRNA to target mRNA was verified by luciferase reporter assay, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blot. A series of the in vitro and in vivo experiments were conducted to examine the mechanism of the overexpression or knockdown of the miRNA and/or target gene. Results. In this study, miR-22-5p was remarkably downregulated in NSCLC than in normal lung cells. The in vitro experiments showed that it could substantially inhibit NSCLC cell proliferation, invasion, migration, and epithelial–mesenchymal transition (EMT) progression. The results of luciferase reporter assay, qRT-PCR, and Western blot revealed that TWIST2 was a direct target gene of miR-22-5p. The results of in vitro and in vivo feedback experiments further demonstrated that miR-22-5p relied on TWIST2-induced malignant progression to regulate NSCLC proliferation, metastasis, and EMT progression. Conclusions. This study revealed that miR-22-5p downregulation contributed to the malignant progression of NSCLC by targeting TWIST2. The findings highlight a potential novel pathway that could be therapeutically targeted in treating NSCLC.
Application of Functional Nanomaterials in Process Design and Art Design
Authors: Liu Meng
Published: September 2022

Coating is a kind of decorative material with decorative function, protection function, adjustment function, and various special functions. In recent years, with the continuous improvement of people’s material living standards, the relationship between environmental protection and health, environment and future development, and environment and nature has been increasingly deepened. The coating industry has developed rapidly in recent years. Nanomaterials have received much attention for their unique physical and chemical properties. Using nanomaterials to modify traditional coatings is a way to rapidly improve the development of the coating industry. In this paper, the properties and preparation technology of nano-TiO2 and nano-ZnO are reviewed, the photocatalytic mechanism of TiO2 and ZnO nanomaterials is discussed, and the two are applied in traditional coating systems to develop nanocomposite coatings. The nano-TiO2 and nano-ZnO components were added to the pure acrylic and silicon acrylic coatings according to a certain proportion to explore the influence of different proportions of nanomaterials on the performance of the above coatings. The results showed a significant improvement in the main performance of the coating at the addition amount of 0.4%. Overall, the modification effect of the nanocomposite component was the most significant, and the nano-ZnO was better than the nano-TiO2, and silicon propylene paint is better performance than pure propylene paint. The ratio of coating pairs prepared in the experiment was 0.98, the brush resistance number was 1990, the adhesion level was level 1, and the reflectance was decreased by 8.58%. The introduction of functional nanomaterials can significantly improve the contrast ratio, scrub resistance, and adhesion of coatings.
Ideology in Sino-Foreign Cooperative Education: The Application of Big Data Mining Technology in the Work Conducted by Counselors
Authors: Shu Ziqin
Published: September 2022

The globalization of today’s world economy is developing in depth, and international education has gradually taken a new step in order to cultivate higher education talents who can adapt to the new context of development. Sino-foreign cooperative education is the main means for the country to carry out international education and foreign exchange, and it aims to cultivate complex talents who can adapt to the new international trade and exchange in the world. Due to the special nature of the student source and the complexity of the purpose of the school, the teaching concept and mode of Sino-foreign cooperative schools differ greatly from the traditional general higher education, which also puts forward strict requirements on the professional level of counselors. As an emerging technology, big data mining technology has a unique advantage in optimizing the processing and management of a large amount of data. The application of big data mining technology to the management of counselors in Sino-foreign cooperative education is important for improving the quality of education, establishing an efficient educational model of Sino-foreign cooperative education, and promoting the international modernization of national education.
Feasibility Analysis of 3D Printing-Assisted Pedicle Screw Correction Surgery for Degenerative Scoliosis
Authors: Chen Xuanhuang , Gao Xiaoqiang , Zheng Feng , Lin Haibin
Published: September 2022

Objective. To explore the feasibility of 3D printing-assisted pedicle screw correction surgery for degenerative scoliosis. Methods. From January 1, 2015 to January 31, 2020, patients with degenerative scoliosis who received corrective surgery in our hospital were retrospectively analyzed. Patients were grouped based on the fixation methods. Patients in the control group received traditional pedicle screw internal fixation, while those in the study group received 3D printing-assisted pedicle screw fixation. The therapeutic effects were compared. Results. There were 78 cases in the control group and 82 cases in the study group. There were no significant differences in scoliotic Cobb’s angle, pelvic incidence-lumbar lordosis (PI-LL), VAS score, JOA score, social function, physical function, role function, or cognitive function between the study group and the control group before the surgery, but there were differences in the above parameters between the two groups after surgery. The incidence of postoperative complications in the study group was also significantly lower in the study group. Conclusion. 3D printing-assisted pedicle screw correction surgery provides a strong 3D correction force with reliable effect and fewer complications, and is a good treatment choice for degenerative scoliosis.
Effect of Different Fat and Moringa oleifera Leaf Meal (MOLM) Inclusion Levels on Proximate Composition, Fatty Acid Profile, and Lipid Oxidation of Chicken Droëwors
Authors: Tembela Nelisiwe , Mukumbo Felicitas Esnart , Hugo Arno , Jaja Ishmael Festus
Published: September 2022

We present the first report on the effect of graded levels of Moringa oleifera leaf meal (MOLM) (0, 0.25, and 0.5%) and fat (0, 10, and 15%) on fatty acid profile, lipid oxidation, and proximate composition of chicken droëwors. On triplicate samples of all treatments, proximate analysis was done, the total lipid was quantitatively extracted using chloroform and methanol in a ratio of 2 : 1, fatty acid profiles were determined, and thiobarbituric acid reactive substances (TBARS) were measured. The present study showed that droëwors manufactured with 0% fat inclusion had less fat and more protein than those made with 10% and 15% fat. All treatments contained a greater percentage of C18:1c9 (oleic) (30.95 to 32.65%) acid than other fatty acids and a higher proportion of unsaturated fatty acids than saturated. T9 (15% fat, 0.5% MOLM) had significantly (

P
<
0.05

) higher PUFAs than T1 (0% fat, 0% MOLM) and T4 (10% fat, 0% MOLM). Treatments with 0.5% MOLM had significantly lower TBARS values after drying (0.01-0.07 mg MDA/kg) than treatments with 0% and 2.5% MOLM (0.05–0.15 mg MDA/kg). Therefore, MOLM inclusion at 0.25 and 0.5% effectively decreased TBARS of chicken droëwors with up to 15% fat inclusion after 72 h of drying and 168 h of storage and is a potentially good source of natural antioxidants for this traditional dried sausage product.
Research on Ultra-high-speed Armature Nondestructive Recovery Technology of Electromagnetic Railgun
Authors: Chunyan Liang , Li Yang , Hongjun Xiang , Junxiao Wang , Zhiming Qiao
Published: September 2022

Aiming at the nondestructive recovery of ultra-high-speed armature of electromagnetic railgun, a mathematical model of fluid medium for recovery is established based on fluid damping theory. At the same time, the fluid-solid coupling finite element model is constructed, and then the numerical calculation is carried out. Furthermore, the recovery characteristics of different armature speed under different density medium are analyzed, and then the relationship between the armature initial velocity and the maximum density of medium is given. Additionally, the overload limit of aluminum armature is obtained. Finally, the overall scheme of variable density segments is proposed. The experimental system is built and verification experiments are carried out. The research results show that by using piecewise recovery method, low-density medium is selected for the front part and high-density medium is selected for the rear part, the problem of too long distance or too much overload when a single medium for recovery can be solved. Meanwhile, the nondestructive recovery of armature can be realized, and the appearance of armature can be maintained.
[Retracted] Study on the Practice of Enterprise Financial Management System under the Epidemic Norm Based on Artificial Neural Network
Authors: Ji Kaiheng
Published: September 2022

The sudden arrival of the new crown epidemic has had a significant and long‐lasting impact on the division’s economic environment as well as the production and operation activities of businesses. As far as the financial management is concerned, opportunities and difficulties are faced by enterprises of all types. With reference to the available research data, enterprises have an important contribution to GDP and jobs, but they still face a series of difficulties and challenges in their development in the context of the normalization of the epidemic. By analyzing the impact of the new crown pneumonia epidemic on the financial management work of enterprises, this paper proposes an artificial neural network‐based enterprise financial forecasting and early warning method to provide an effective method for enterprise financial management. For the time‐series characteristics of enterprise finances, a prediction model based on long‐ and short‐term memory networks is developed which acknowledges the necessity of combining the temporal dimension with the spatial dimension for forecasting. This model incorporates time qualities into the data to the existing forecasting model. It also considers both working and nonworking day data and thoroughly considers the factors influencing corporate finance. Then, using BP neural network for financial risk prediction, nonfinancial index factors should be added to the financial early warning model thus eliminating the limitations of the financial early warning model. At the same time, the accuracy of the prediction can be improved which is more suitable for enterprises to apply in practice. The experimental results demonstrate that the financial prediction model built by multilayer feed forward neural networks and recurrent neural networks based on error back propagation training is inferior to the prediction model built by long‐ and short‐term memory network. Regardless of the degree of fitting or prediction accuracy, the BP neural network model outperforms the conventional model for enterprise financial warning. Under the normalization of the pandemic, the combined use of both can offer an efficient technique for enterprise management.
Effectiveness of Cognitive Behavior Therapy Combined with Eye Movement Desensitization and Reprocessing on Psychological Problems and Life Quality in Patients’ Postfacial Trauma
Authors: Lin Yue , Lv Wang , Xu Jun , Jiang Yingying , Chen Zheyan
Published: September 2022

Objective. To investigate the effectiveness of cognitive behavior therapy (CBT) combined with eye movement desensitization and reprocessing (EMDR) on the esteem, anxiety, depression, posttrauma stress disorder (PTSD), and posttraumatic growth in patients with facial trauma. Methods. A total of 92 facial trauma patients in Wenzhou People’s Hospital from January 2017 to December 2019 were enrolled in this study. The patients were randomly divided into control group (

n
=
46

) and intervention group (

n
=
46

). Both of the control group and the intervention group received routine treatment, while the intervention group further received CBT combined with EMDR. Questionnaires were used to explore and record the general patient information. The Self-Esteem Scale (SES), Self-Anxiety Scale (SAS), Self-Depression Scale (SDS), Posttraumatic Stress Disorder Checklist Civilian Version (PCL-C), Posttraumatic Growth Inventory (PTGI), and World Health Organization Quality of Life-brief (WHOQOL-BREF) scores between the two groups were compared. Results. After CBT combined with EMDR intervention, the SDS and SAS scores in the intervention group were significantly decreased compared with the scores before intervention with statistically significance (

P
<
0.001

). Furthermore, the PCL-C score in the intervention group showed significant decrease in comparison with the control group (

P
<
0.001

), while the PTGI score in the intervention group was significantly higher than the control group (

P
<
0.001

). The WHOQOL-BREF scores were increased after treatment in the two groups compared with the scores before treatment, and the scores in the intervention group were higher than those in the control group after treatment (

P
<
0.01

). Conclusion. Psychological intervention therapy can effectively alleviate the anxiety, depression, and PTSD and improve the life quality and the recovery of facial trauma patients.
Construction of a Safety Management System for University Laboratories Based on Artificial Intelligence and IoT Technology
Authors: Ding Jing
Published: September 2022

Based on IoT technology, it can combine the actual needs of the university laboratory system to establish an equipment safety monitoring system, share data in real time, and monitor the operation equipment of university laboratories comprehensively. Through the collection of equipment-related data, we have a comprehensive analysis of data in order to have an accurate judgment of the state of the equipment, so that the chances of equipment failure can be gradually reduced. In this paper from the architectural point of view, IoT contains four layers: perception layer, network layer, platform layer, and application layer. The perception layer mainly solves the problem of data collection, the network layer mainly solves the problem of data transmission, the platform layer mainly solves the problem of data management, and the application layer mainly solves the problem of data value creation. From the technical point of view, the university laboratories’ Internet of Things widely used big data, cloud computing, Internet of Things, artificial intelligence, blockchain, edge computing, and other types of information technology and intelligent technology. From the role, the university laboratories’ IoT is to provide sufficient and effective information and technical support for planning and construction, production and operation, operation and management, integrated services, new business, new model development, enterprise ecosystem construction, and other aspects by bringing together resources from all aspects. The whole university laboratory system sustainability monitoring equipment maintains the continuity of monitoring and can be the first time to staff feedback fault information, to achieve the human-machine dialogue function; staff in the control of equipment safety monitoring system just enter the relevant instructions to fully achieve the purpose of control; staff can also print a certain period of time fault-related information, which will be properly stored in a reasonable location.
Immediate Sequential Bilateral Cataract Surgery: Opinions among Refractive Surgeons in the United States and a Comparative Analysis with European Consultants
Authors: Rush Sloan W. , Guerrero Criado Andres E. , Kezirian Guy M. , Durrie Daniel
Published: September 2022

Purpose. To analyze the perspectives of practicing refractive surgeons regarding the implementation of Immediate Sequential Bilateral Cataract Surgery (ISBCS) in the United States (US) and to compare their perspectives with those of European colleagues. Setting. Online refractive surgery forum. Design. A survey-based questionnaire. Methods. An electronic survey was emailed to all surgeon members of the Refractive Surgery Alliance (RSA) in the US. Participants were prompted to score their impressions regarding various aspects regarding ISBCS. Responses were compared to published reports conducted among European surgeons. Results. The electronic link to the survey was emailed to US-based surgeon members of the RSA, where 107 participated (44.6%). Twenty-seven (25.2%) reported that they currently perform ISBCS. Twenty-three (22.5%) of the respondents indicated they felt ISCBCS should be offered as a standard of care for routine cataract surgery. For surgeons that do not perform ISBCS, the most important factors were related to medicolegal issues and decreased reimbursement, whereas evidence of effectiveness and complications related to ISBCS were less important. Compared to practitioners abroad, 67.2% of European ophthalmic surgeons, compared to 25.2% of US surgeons, perform ISBCS (

p
<
0.0001

). Conclusions. While US refractive surgeons often perform bilateral corneal procedures, many significant barriers exist to the widespread adoption of ISBCS. Concerns reported by US surgeons mirror those reported by surgeons in Europe. The majority of the US refractive surgeons in this survey indicate that ISBCS should not be the standard of care in routine cases, with the prevailing reason being concerns about decreased physician reimbursement and potential medicolegal issues, not safety.
Application of Cloud Service in Smart Tourism Management Based on Weighted Average Algorithm
Authors: Feng Ye
Published: September 2022

Tourism has become the main force driving urban economic development. However, there are problems such as low utilization rate of tourism resources and inconsistency of tourism information. The new smart tourism management model can sense tourism resources, tourist information, tourism development, and other information in a timely manner through terminal devices such as the Internet. The core of smart tourism management is to obtain travel information of travelers through cloud service technology, organize travel information, and recommend personalized travel plans for travelers. Apply cloud services to smart tourism management, and use the weighted average algorithm to make regression predictions on passenger information. This paper compares and analyzes the application of cloud service based on the algorithm for calculating the weighted average and the application of ordinary cloud service in smart tourism management through experiments. The experimental results show that the cloud service by adding weights can improve the forecast of the traveler’s information by 36% and 22%, respectively, compared with the cloud service of the ordinary average algorithm. Also, the effect of tourists’ travel experience is 72.2% and 56.3%, respectively. In the forecast of tourism information in tourism resources, tourism economy, and tourism activities, cloud services by adding weights maintain stable economic growth and improve tourists’ tourism experience. The cloud service in the smart tourism management of the weighted average algorithm can formulate corresponding tourism marketing strategies through the integration and prediction of tourism information, enhance the growth of the tourism economy, and improve the tourism experience of tourists.
Predictive Factors for Late‐Onset Neurological Deficits in Patients with Posttuberculous Thoracic Kyphosis
Authors: Zhao Jianquan , Cai Zhuyun , Meng Yicheng , Zhou Xuhui , Jiang Heng
Published: September 2022

Study Design. This study was a retrospective, single‐center study. Background. Patients with severe posttuberculous (TB) kyphosis might suffer from late‐onset neurological deficits, and surgical correction may improve neurological function. However, there is a lack of predictive factors for neurological function in these patients. Objective. This study was aimed at identifying the risk factors for late‐onset neurological deficits in spinal TB patients at initial and final assessments. Methods. Seventy‐eight patients with severe kyphosis caused by old thoracic tuberculosis were retrospectively analyzed. Patients with active spinal TB and other spinal diseases were excluded from the analysis. The kyphosis Cobb angle, sagittal deformity angular ratio (S‐DAR), and level of apex were measured and calculated on X‐ray. The spinal cord cross‐sectional area ratio (CSAR), spinal cord sagittal diameter ratio (SDR), and spinal cord angle (SCA) were measured on preoperative T2‐weighted magnetic resonance imaging (MRI). According to the American Spinal Injury Association (ASIA) Impairment Scale (AIS) at the time of admission, the patients were divided into the symptomatic group (N = 60 patients, AIS grades A to D) and the asymptomatic group (N = 18 patients, AIS grade E). All of the symptomatic patients underwent surgery, and the patients from both groups had at least 2 years of follow‐up. Relationships among the radiological parameters and initial and final AIS grades were evaluated via univariate and multivariate analyses. Results. The mean duration of kyphotic deformity was 37.4 years in the symptomatic group. There were no significant differences between the two groups in terms of CSAR, kyphosis Cobb angle, S‐DAR, level of apex, or the segments that were involved. Patients from the symptomatic group exhibited significantly greater SDR and smaller SCA than those from the asymptomatic group (p < 0.01 and p < 0.01, respectively). The multivariate logistic regression identified SDR and SCA as independent factors influencing the likelihood of spinal cord injury at the initial and final assessments. Conclusions. Severe posttuberculous kyphosis may lead to significant neurological symptoms many years following the initial treatment. The predictive factors for late‐onset neurological deficits include larger SDR and smaller SCA.
Reconnoitring Wear Resistance and Mechanical Strengths of AA8111/B4C/ZrO2 Nanocomposite through Taguchi Route
Authors: Thanakodi Sathish , Vinayagam Mohanavel , Ravichandran M. , Raja T. , Seikh A. H. , Siddique M. H. , Hailu Beruk
Published: September 2022

Nowadays, the use of aluminium alloys is increasing in all domains of application, including industry, medical, electrical, and household appliances. In general, aluminium alloy is a lightweight material with great strength when compared to other alloys. According to the uses, the aluminium alloy must be strengthened by the inclusion of reinforced particles via the stir casting process. The purpose of this study was to create nanocomposite samples of AA8111/B4C/ZrO2 using a stir casting procedure. To prepare nanocomposite samples, the matrix of aluminium alloy AA8111 is supplemented with nanoparticles of boron carbide (B4C) and zirconium dioxide (ZrO2) in varied proportions. Optimize the stir casting parameters using a statistical approach such as the Taguchi technique to improve mechanical and wear attributes. The following process parameters were chosen: nanoparticle reinforcement quantity (4% to 10% with the step of 2%), melting temperature (800°C to 950°C with the step of 50°C), stir time (20 min to 35 min with the step of 5 minutes), and stir speed (400 rpm to 550 rpm with the step of 50 rpm). Wear and tensile strength tests are performed; the melting temperature is heavily impacted in the wear test, and the stir speed is heavily influenced in the tensile strength analysis. This experimental effort yielded a minimum wear of 0.085 mm3/m and a maximum ultimate strength of 167.6 N/mm2.
Exhaustive Search and Power‐Based Gradient Descent Algorithms for Time‐Delayed FIR Models
Authors: Chen Hua , Ji Yuejiang
Published: September 2022

In this study, two modified gradient descent (GD) algorithms are proposed for time‐delayed models. To estimate the parameters and time‐delay simultaneously, a redundant rule method is introduced, which turns the time‐delayed model into an augmented model. Then, two GD algorithms can be used to identify the time‐delayed model. Compared with the traditional GD algorithms, these two modified GD algorithms have the following advantages: (1) avoid a high‐order matrix eigenvalue calculation, thus, are more efficient for large‐scale systems; (2) have faster convergence rates, therefore, are more practical in engineering practices. The convergence properties and simulation examples are presented to illustrate the efficiency of the two algorithms.
Efficacy Analysis of Comprehensive Nursing in the Care of Ovarian Carcinoma Treated with Paclitaxel Combined with Nedaplatin
Authors: Li Yahui , Wu Jing , Zhu Gehong
Published: September 2022

Objective. To determine the effectiveness of comprehensive nursing in the care of ovarian carcinoma (OC) patients treated with paclitaxel (PTX) plus nedaplatin (NDP). Methods. The research population comprised 180 advanced OC patients who received treatment in the Shaanxi Cancer Hospital between November 2018 and November 2021. The enrolled cases were assigned to two groups based on different nursing plans: an observation group (OG) with 100 cases treated with comprehensive nursing and a control group (CG) with 80 cases intervened by conventional nursing. Intergroup comparisons were performed to identify statistical significance in terms of the following parameters: serum NGF, TK1, and CA15-3 levels; VAS, SAS, and SDS scores; nursing compliance; incidence of adverse reactions; and nursing satisfaction. Results. Compared with CG, OG showed the following: (1) lower posttreatment NGF, TK1, and CA15-3 levels; (2) lower scores of SAS and SDS; (3) higher nursing compliance; and (4) lower incidence of adverse reactions and higher nursing satisfaction after nursing. Conclusions. Comprehensive nursing far outperformed conventional nursing in the care of advanced OC patients treated with PTX plus NDP, which is worth popularizing.
Association between Adiponectin and Leptin Receptor Genetic Polymorphisms and Clinical Manifestations of Metabolic Syndrome
Authors: Shramko Iuliana I. , Ageeva Elizaveta S. , Maliy Konstantin D. , Repinskaya Irina N. , Tarimov Cyrill O. , Fomochkina Iryna I. , Kubishkin Anatolii V. , Ostapenko Olga V. , Gurtovaya Anna K. , Shekhar Suman
Published: September 2022

Abdominal obesity coupled with polygenic hereditary defects is considered the initial event in the development of metabolic syndrome (MS). The purpose of this study was to analyse the frequency with which polymorphic loci of adiponectin (ADIPOQ) and leptin (LEP) genes occur in patients with MS and the association between the symptoms of MS and these polymorphisms. DNA was isolated from the whole blood of 207 patients with MS and 100 healthy individuals (control group) using the phenol-chloroform method. Gene polymorphisms were determined using real-time polymerase chain reaction (PCR). The most common variant of the ADIPOQ (rs2241766) gene among MS patients was the GT genotype. The A allele of the LEP (rs7799039) gene was found to be the most frequent in MS patients. The highest systolic blood pressure was found in carriers of the GG genotype of the LEP (rs7799039) gene. The carriers of the ADIPOQ (rs2241766) GT genotype were associated with the highest systolic blood pressure and body mass index (BMI); carriers of the ADIPOQ (rs2241766) GG genotype were associated with the highest diastolic blood pressure, hyperglycaemia, and elevated glycated haemoglobin (HbA1c). The results of this study allowed us to establish the unique gene variants associated with the risk of developing MS in the Crimean population.
Genomic Characteristics and Single-Cell Profiles After Immunotherapy in Fumarate Hydratase-Deficient Renal Cell Carcinoma
Authors: Dong Pei , Zhang Xinyue , Peng Yulu , Zhang Yijun , Liu Ruiqi , Li Yilin , Pan Qiwen , Wei Wensu , Guo Shengjie , Zhang Zhiling , Han Hui , Zhou Fangjian , Liu Yang , He Liru
Published: September 2022

Purpose:

Fumarate hydratase–deficient renal cell carcinoma (FHRCC) is highly malignant, but the urgent need for effective treatment remains unmet. We aimed to analyze the genomic characteristics and microenvironment of FHRCC and the cause of heterogeneous response to immune checkpoint inhibitor (ICI)-based treatment at single-cell level.

Experimental Design:

Whole-exome sequencing and IHC staining analyses were performed in 30 advanced FHRCC patients. Single-cell RNA sequencing following ICI-based treatment was conducted in 4 patients. The clinical characteristics, therapeutic effect, and follow-up data were analyzed.

Results:

The median tumor mutation burden was only 0.14 mutations per megabase. IHC staining showed an immune-active tumor microenvironment characterized by extensive CD8+ T-cell infiltration. ATM expression was inversely correlated with percentage of tumor-infiltrating CD8+ T cells. Trajectory analysis indicated gradually upregulated exhausted markers and an increased apoptotic trend of CD8+ T cells despite continuous exposure to ICI-based treatment. ICI-based treatment was associated with improved overall response rate (17.6% vs. 0%, P = 0.046) and disease control rate (DCR; 64.7% vs. 12.5%, P = 0.004) compared with tyrosine kinase inhibitor. Among patients with germline mutation, the ORR (16.7% vs. 0%, P = 0.086) and the DCR (66.7% vs. 14.3%, P = 0.011) were higher after ICI-based treatment.

Conclusions:

Immune infiltration is frequent in FHRCC. ICI-based treatment is a promising regimen, and treatment response depends on the functional status of tumor-infiltrating lymphocytes. ICI-based treatment cannot reverse the exhaustion of CD8+ T cells in patients with progressive disease, highlighting the need for additional therapeutic strategies.