bluuebunny/crossref_metadata_2025 huggingface dataset:
Theoretical investigation of electromagnetic-thermal coupling of double-layer cylindrical concrete under microwave irradiation
Authors: Wei Wei , Qiao Rujia , Jiang Yan Song , Shao Zhushan
Published: April 2024

Many experiments have been performed to study the heating properties of concrete under microwave irradiation. Microwave provides the non-uniform heating process, which cannot be reflected clearly through the experimental investigations. In this paper, a theoretical method is presented to investigate the electromagnetic-thermal coupling process of double-layer cylindrical concrete under microwave heating. The wave transmission and reflection were considered. An analytic solution is presented to predict transient heating process within a 3-dimensional double-layer concrete model induced by microwave heating. The inner aggregate is a microwave high loss material and the outer mortar was microwave low loss medium. Poynting theorem was employed to calculate the electric field distribution and microwave energy loss within concrete. Transient heat transfer process with an internal microwave heat source was investigated based on the classical heat transfer theory by employing integral transform technique. The results indicate that microwave heating effect depend on the concrete size, dielectric properties as well as microwave energy input. The temperature gradient was formed at the mortar-aggregate interface, which varied with the microwave heating parameters inputs. The analytical study will provide significant insight to promote the understanding of electric and temperature field in the two-layer composite concrete materials under microwave heating.
Prevalence and Severity of Burnout Risk Among Musculoskeletal Allied Health Practitioners: A Systematic Literature Review and Meta-analysis
Authors: Clarke Mia , Frecklington Mike , Stewart Sarah
Published: April 2024

This systematic literature review and meta-analysis aimed to determine the prevalence and severity of burnout among musculoskeletal allied health clinicians according to the three dimensions of burnout – emotional exhaustion, depersonalisation, and personal accomplishment. Search terms were used to identify original research articles investigating burnout among musculoskeletal allied health professionals (chiropractors, occupational therapists, physical therapists, and podiatrists) using three electronic databases. To ensure consistency across data analysis and interpretation, only studies which employed the gold standard Maslach Burnout Inventory to measure burnout risk were included. Meta-analyses were conducted to calculate the pooled prevalence of high burnout for each of the three domains of the Maslach Burnout Inventory (emotional exhaustion, depersonalisation, personal accomplishment). Subgroup analyses by health profession and continent were also conducted. The search identified 54 eligible studies for inclusion. The pooled prevalence of high burnout risk for each of the three domains of the Maslach Burnout Inventory were as follows: high emotional exhaustion, 0.40 (95% confidence interval: 0.29–0.51); high depersonalisation, 0.26 (95% confidence interval: 0.07–0.53); and low personal accomplishment, 0.25 (95% confidence interval: 0.05–0.53). Pooled mean total scores indicated moderate levels of burnout risk across all three domains. Subgroup analyses showed physical therapists had the greatest overall burnout risk, and chiropractors the lowest. Geographical differences were also observed. Musculoskeletal allied health professionals frequently experience increased burnout risk related to emotional exhaustion and depersonalisation. Differences in burnout risk prevalence and severity were also evident among professions and geographical locations, indicating that techniques for resolving burnout should be adapted to specific professions and cultural contexts.
Self-healing hybrid intrusion detection system: an ensemble machine learning approach
Authors: Kushal Sauharda , Shanmugam Bharanidharan , Sundaram Jawahar , Thennadil Suresh
Published: April 2024

The increasing complexity and adversity of cyber-attacks have prompted discussions in the cyber scenario for a prognosticate approach, rather than a reactionary one. In this paper, a signature-based intrusion detection system has been built based on C5 classifiers, to classify packets into normal and attack categories. Next, an anomaly-based intrusion detection was built based on the LSTM (Long-Short Term Memory) algorithm to detect anomalies. These anomalies are then fed into the signature generator to extract attributes. These attributes get uploaded into the C5 training set, aiding the ensemble model in continual learning with expanding signatures of unknown attacks. By generating signatures of unknown attacks, the self-healing attribute of the ensemble model contributes to the early detection of attacks. For the C5 classifier, the proposed model is evaluated on the UNSW-NB15 dataset, while for the LSTM model, it is evaluated on the ADFA-LD dataset. Compared to conventional models, the experimental results show better detection rates for both known and unknown attacks. The C5 classifier achieved a True Positive Rate of 97% while maintaining a false positive rate of 8%. Also, the LSTM model achieved a detection rate of 90% while retaining a 17% False Alarm Rate. As the proposed model learns, its performance in real network traffic also improves and it also eliminates human intervention when updating training data.
Genetic evidence for functions of Chloroplast CA in Pyropia yezoensis: decreased CCM but increased starch accumulation
Authors: Zhang Baoyu , Liu Xueying , Xie Xiujun , Huan Li , Shao Zhizhuo , Du Zhiyan , Wang Guangce
Published: April 2024

In response to the changing intertidal environment, intertidal macroalgae have evolved complicated Ci utilization mechanisms. However, our knowledge regarding the CO2 concentrating mechanism (CCM) of macroalgae is limited. Carbonic anhydrase (CA), a key component of CCM, plays essential roles in many physiological reactions in various organisms. While many genes encode CA in the Pyropia yezoensis genome, the exact function of specific CA in P. yezoensis remains elusive. To explore the particular function of chloroplast CA in intertidal macroalgae, we produced chloroplast-localized βCA1 knockdown mutants of P. yezoensis through RNA interference, and Pyβca1i mutants (hereinafter referred to as ca1i) showed a notable decrease in leaf area and overall biomass, as well as decreased soluble protein and unsaturated fatty acid content under different DIC conditions. However, ca1i mutants showed relatively higher starch content compared to the wild-type. The activity of enzymes involved in the Calvin cycle, photorespiration, Pentose-phosphate pathway, and floridean starch synthesis of P. yezoensis indicated an effective starch accumulation pathway after the interference of βCA1. All results suggest that the decreased activity of PyβCA1 impaired the CCM and development of thalli of P. yezoensis, but stimulated starch accumulation in the cytoplasm through feedback to the photorespiration pathway and pentose phosphate pathway to replenish intermediates for the Calvin cycle. This study is the first to explore the specific function of chloroplast CA in intertidal macroalgae using genomic technology. The results provide valuable insights into the adaption mechanisms of intertidal macroalgae to their environment.
Suspension of Belief
Authors: Vazquez Daniel
Published: April 2024

This Element offers a systematic outline of ancient conceptions and uses of suspension of belief (understood broadly) while engaging with contemporary philosophy. It discusses the notion of epochē ('suspension of judgement') and other related terms, like aporia, aphasia, paradox, hypothesis, agnosticism, and Socratic wisdom. It examines the Academic and Pyrrhonian sceptics and some of their arguments and strategies for suspension. It also includes the use and conditions for suspension of belief in other philosophers like Socrates, Plato, Aristotle, the Stoics, Plotinus, Protagoras, and Democritus. The Element is divided into four thematic sections, each addressing one of the following questions: What is suspension of belief? When does it arise? What could its scope be? And what are its practical and moral implications?
Chinese Émigré Composers and Divergent Modernisms
Authors: Chung Mia
Published: April 2024

This Element examines the factors that drove the stylistic heterogeneity of Chen Yi and Zhou Long after the Cultural Revolution. Known as 'New Wave' composers, they entered the Central Conservatory of Music once the Cultural Revolution ended and attained international recognition for their modernism after their early careers in America. Scholars have often treated their early music as contingent outcomes of that cultural and political moment. The author proposes unique personal factors that shaped their modernisms despite their shared experiences of the Cultural Revolution and education at the Central Conservatory and Columbia University. Through interviews on the six stages of their development, the author examines and explains the reasons for their stylistic divergence.
Islam and Environmental Ethics
Authors: Gada Muhammad Yaseen
Published: April 2024

This Element explores environmental ethics in Islam. Its core argument is that Islamic culture and civilization are rich in environmental concerns; Islam has unique considerations and directions about what sort of human-nature relationship there should be. Muslim environmental commentators have explored basic environmental or eco-ethical principles that are deeply embedded in the Qur'an and Sunnah. Protecting and conserving the environment are not only moral duties but also an obligation in Islam. The Islamic environmental ethical system offers both conceptual paradigms and operational components to realize environmental justice and sustainable development.
Values and Ethics
Authors: Cribb Alan , Entwistle Vikki , Mitchell Polly
Published: April 2024

Ethics involves examining values and identifying what is good, right, and justified – and why. Diverse values and ethical issues run through healthcare improvement, but they are not always recognised or given the attention they need. While much effort goes into understanding whether intervention X effectively leads to change Y, questions such as 'is X ethically acceptable?', 'does Y count as an improvement?', 'should Y be prioritised?', and 'if so, why?' are sometimes neglected. This Element demonstrates the ethical considerations and rich array of values that inevitably underpin both the goals of healthcare improvement (what aspects of quality or what kinds of good are pursued) and how improvement work is undertaken. It outlines an agenda for improvement ethics with the aim of helping those involved in healthcare improvement to reflect on and discuss ethical aspects of their work more explicitly and rigorously. This title is also available as Open Access on Cambridge Core.
Evolutionary Perspectives on Enhancing Quality of Life
Authors: Larsen Mads , Witoszek Nina
Published: April 2024

Positive psychology is a thriving field with increasing political influence, yet there are few evolutionary studies that have had a tangible impact on rethinking mechanisms of well-being. This Element reviews existing literature and proposes synthesizing insights into human flourishing under an umbrella of multilevel selection (MLS). Conceptualizing quality of life as 'Happiness + Meaning = Well-being' draws attention to how people navigate between individual and group needs, and how they reconcile selfish pursuits with altruism and cooperation. We define happiness as the cluster of affects that reward individuals for solving adaptive challenges. We approach meaning as a reward that individuals experience when contributing to their community. By way of examples, we critically examine the Nordic well-being societies whose ethos and education advance prosocial values and practices and strike a balance between individualist and communitarian ideals. This title is also available as Open Access on Cambridge Core.
Film Festivals, Ideology and Italian Art Cinema
Authors: Johnson Rachel
Published: April 2024

Film Festivals, Ideology and Italian Art Cinema is the first systematic study of the role ideology plays in film festivals' construction of dominant ideas about art cinema.

Film festivals are considered the driving force of the film industry outside Hollywood, disseminating ideals of cinematic art and humanist politics. However, the question of what drives them remains highly contentious.

In a rare consideration of the European competitive film festival circuit as a whole, this book analyses the shared economic, geopolitical and cultural histories that characterise 'European A festivals'. It offers, too, the first extensive analysis of such festivals' role in the canonisation of select Italian films, from Rome, Open City to The Great Beauty and Gomorrah.

The book proposes a new approach to ideology critique, one that enables detailed examination of how film festivals construct ideas about not only contemporary art cinema, but assumptions about gender, race, colonialism and capitalism.
Lusaka Call-to-Action 2022: A Call to Strengthen Public Health Emergency Operation Centers in Africa
Authors: Eteng Womi-Eteng Oboma , Mankoula Wessam , Aragaw Merawi , Sonko Ibrahima , Tut Mathew , Kibiye Dennis , Riek Lul , Ouma Ahmed Ogwell
Published: April 2024

In July 2022, on the sidelines of the 41st Ordinary Session of the Executive Council of the African Union and the 4th Mid-Year Coordination Summit in Lusaka, Zambia, Heads of state and government, and leaders of delegations of African Union Member States called on member states, African Union through Africa CDC, and partners to recognize, prioritize, and accelerate the establishment and strengthening of public health emergency operation centers (PHEOCs) in the context of health security and in line with Africa’s new public health order. Implementing the declaration requires a multi-dimensional approach that spans across governance, operational capabilities, partnerships, workforce development, and sustainable financing.
With Haraway and Beyond: Towards an Ecofeminist and Contextual Vegan Ethico-Politics
Authors: Castelló Pablo P.
Published: April 2024

Some ecofeminist scholars have argued that being a feminist entails being a contextual vegan. Donna Haraway has opposed this position and received extensive critique. Yet no one, to my knowledge, has systematically studied how Haraway's theory can enrich ecofeminist vegan literature. To this end, I first establish the method of analysis, and/or framework, I use to read Haraway's work, what I call, interconstitutionality. Next, I delineate the limitations of Haraway's thinking insofar as it assumes a position of human dominion over animals. I then explore some aspects of Haraway's theory that can enrich ecofeminist vegan scholarship and provide insights to go beyond the limits of Haraway's corpus regarding: (1) the entanglements and embodied vulnerabilities that constitute human and non-human animals; (2) the agency of animals and the importance of curiosity and respect in leading just lives with other than human animals; (3) the ethical relevance of otherness, difference, and vulnerability at multiple scales: subject, community/herd, species, and cross-species (e.g., there are shared vulnerabilities between beings who are pregnant regardless of the species they belong to); and (4) the unavoidable violence that human existence entails. The text closes by affirming an ecofeminist non-anthropocentric vegan ontology and ethico-politics that aspires to overcome human dominion over animals.
Quality and antioxidant potential of goat's milk paneer prepared from different citrus juices and its whey
Authors: Qureshi Tahir Mahmood , Saeed Muhammad Mobeen , Nadeem Muhammad , Muhammad Ghulam , Murtaza Mian Anjum , Ibrahim Salam A.
Published: April 2024

The experiments reported in this research paper aimed to evaluate the physico-chemical and sensory characteristics, microbial quality and antioxidant potential of goat's milk paneer during storage (0–12 d, 4 ± 1°C). The juices from five different citrus fruits were used as coagulant (treatments) to make goat's milk paneer. The pH of all paneer samples decreased during storage whereas titratable acidity increased. Ash (%) fat (%) and protein (%) of paneer increased slightly during storage, whereas sensory perception decreased. The juices from all the citrus fruit varieties showed high contents of total phenolics and total flavonoids which ultimately influenced ferric reducing antioxidant power, total antioxidant capacity and radical scavenging activities. As the contents of different juices were also retained in the paneer matrix, so paneer coagulated with citrus juices also showed encouraging results in terms of total phenolic and flavonoid contents, ferric reducing antioxidant power and radical scavenging activities. Amongst all the paneers, the most promising was that coagulated by kinnow juice. In addition, the whey obtained from paneer coagulated by citrus juices also showed appreciable quantities of total phenolic and flavonoid contents, thereby beneficially influencing ferric reducing antioxidant power andradical scavenging activities. It is concluded that citrus juices improve the sensorial quality and antioxidant potential of goat's milk paneer and its whey.
Private law, private international law and public interest litigation
Authors: Law Stephanie , Shaw Jo , Havercroft Jonathan , Kang Susan , Wiener Antje
Published: April 2024

Private actors and institutions, and by extension private law itself, are increasingly being forced to reckon with a multiplicity of challenges that extend beyond the domain of private law as it is traditionally conceived. They reflect threats to the global constitutional order and liberal constitutionalism, and threats to individual and collective fundamental rights and constitutional values. As a result, the role of private law in framing and facilitating the development of the global economy and globalization often does not fall within the direct purview of public international lawyers. This editorial aims to examine the role of private law in the litigation and enforcement of public interests against the background of the public/private divide. This is done in light of the increasing role adopted by private actors, including corporations, beyond the private realm.
Atmospheric Rivers in the Eastern and Midwestern United States Associated With Baroclinic Waves
Authors: O’Brien Travis A. , Loring Burlen , Dufek Amanda Sabatini , Islam Mohammad Rubaiat , Kamnani Diya , Quagraine Kwesi Twentwewa , Kirkpatrick Cody
Published: April 2024

Atmospheric rivers (ARs) significantly impact the hydrological cycle and associated extremes in western continental regions. Recent studies suggest ARs also influence water resources and extremes in continental interiors. AR detection tools indicate that AR conditions are relatively frequent in areas east of the Rocky Mountains. The origin of these ARs, whether from synoptic‐scale waves or mesoscale processes, is unclear. This study uses meteorological composite maps and transects of AR conditions during the four seasons. The analysis reveals that ARs east of the Rockies are associated with long‐wave, baroclinic Rossby waves. This result demonstrates that eastern North American ARs are dynamically similar to their western coastal counterparts, though mechanisms for vertical moisture flux differ between the two. These findings provide a foundation for understanding future climate change and ARs in this region and offer new methods for evaluating climate model simulations.
Improved Consistency of Satellite XCO2 Retrievals Based on Machine Learning
Authors: Huang Xiaoting , Deng Zhu , Jiang Fei , Zhou Minqiang , Lin Xiaojuan , Liu Zhu , Peng Muyan
Published: April 2024

Quantifying atmospheric CO2 over long periods from space is crucial in understanding the carbon cycle's response to climate change. However, a single satellite offers limited spatiotemporal coverage, making comprehensive monitoring challenging. Moreover, biases among various satellite retrievals hinder their direct integration. This study proposed a machine learning framework for fusing the column‐averaged dry‐air mole fraction of CO2 (XCO2) retrievals from Greenhouse Gases Observing Satellite (GOSAT) and OCO‐2 satellites. The best model (R2 = 0.85) presented improved consistency of GOSAT retrievals by reducing 71.5% of the average monthly bias while using OCO‐2 retrievals as a benchmark, indicating the fusion data set's potential to enhance observation coverage. Incorporating the adjusted GOSAT XCO2 retrievals into the OCO‐2 data set added an average of 84.7 thousand observations annually, enhancing the yearly temporal coverage by 53.6% (from 14 to 21.5 days per grid). This method can be adapted to other satellites, maximizing satellite resources for a more robust carbon flux inversion.
Uranium Isotope Constraints on the Pre‐Deposition Time of Asian Dust to the North Pacific Ocean: Implications for Provenance and Iron Supply
Authors: Li Le , Li Gen K. , Zhang Run , Zhang Wenfang , Hedding David William , Chen Jun , Li Gaojun
Published: April 2024

Asian dust delivers highly reactive iron (FeHR) to the Pacific Ocean, affecting marine biogeochemical cycles and Earth's climate. Tracing the source of dust deposited in the Pacific is vital for assessing global nutrient cycles but poses challenges. This work applies the (234U/238U) activity ratio to determine the pre‐deposition time and provenance of dust in North Pacific Ocean sediments (Ocean Drilling Program site 1209B). Results indicate a consistent dust pre‐deposition time (134 ± 10 ka) over the past 300,000 years, except during Marine Isotope Stage 7 when volcanic ash input shortened it to 31 ± 19 ka. Comparing the dust pre‐deposition times to those of the potential source deserts, we identify the dust transported to the North Pacific Ocean was primarily from the Taklamakan Desert, which contains higher FeHR content than other deserts. This finding enhances our understanding of soluble Fe supplied to the oceans, especially in dust circulation models.
Contribution of Surface Radiative Effects, Heat Fluxes and Their Interactions to Land Surface Temperature Variability
Authors: Liu Y. , Huang Y. , Yuan J. , Xie Y. , Zhou C.
Published: April 2024

Land surface temperature anomalies can be linked to changes in local surface energy balance, although the relationship between surface temperature variability and individual radiative processes remains unclear. In this paper, we quantify the contributions of surface radiative effects and non‐radiative heat fluxes to the variance of monthly land surface temperature using European Centre for Medium‐Range Weather Forecasts Reanalysis v5 data and Coupled Model Intercomparison Project Phase 6 simulations. The surface energy budget equation is used to link changes in surface radiation, surface heat fluxes and land surface temperature. Subsequently, surface radiation is decomposed into the radiative effects of clouds, air temperature, surface albedo and relative humidity using radiative kernels. The contributions of these radiative processes, including their coupling effects, are quantified using covariance matrices. The results reveal the air temperature radiative effect to be the most significant contributor to the variability of land surface temperature. In addition, the covariance terms reveal important coupling effects. For example, the contribution from the cloud radiative effect is found to be substantially dampened by its coupling with surface heat fluxes. The air temperature radiative effect is further decomposed into a forcing component and a feedback component using different regression methods, in an attempt to separate the air temperature radiative effect as the driver of the surface temperature variability. The cloud radiative effect becomes the primary contributor to the variance of surface temperature after separating the air temperature feedback, while the contribution of the air temperature radiative forcing remains important.
Improvement of Global Forecast of Tropical Cyclone Intensity by Spray Heat Flux and Surface Roughness
Authors: Shi Ruizi , Xu Fanghua
Published: April 2024

In global forecasting systems, tropical cyclone (TC) intensity is usually underestimated, which is one of the major challenges for TC forecasting. One possible reason is the deficiency of physical parameterizations associated with ocean surface waves. To improve the TC intensity forecast, effects of two powerful wave‐related processes, the spray‐mediated heat flux and surface roughness, are considered in a global coupled ocean‐atmosphere‐wave system (CFSv2.0‐WW3). Serial 24 hr forecasting experiments for all TCs from May to October 2019 are conducted, and comparisons are made against the International Best Track TC data. The results show that for strong TCs the underestimation of TC intensity in CFSv2.0‐WW3 is significantly improved by the modified surface roughness parameterization and the accelerated spray heat flux parameterization based on Gaussian Quadrature. For major hurricanes with initial wind speeds above 30 m/s, the error of TC maximum wind speed decreases by about 34.4%. To understand the associated dynamic and thermodynamic processes, a series of 120 hr simulations for major hurricane Hagibis is conducted. The effect of spray‐mediated heat flux accounts for 91.7% of the TC intensity improvement. The increased heat fluxes offset the negative contributions of vertical advection and ventilation, leading to enhanced entropy. The low‐level pressure is then decreased, resulting in enhanced convergence of absolute vorticity, which overpowers the negative effects of frictional dissipation and vertical momentum advection. The study indicates that the application of these two wave‐related parameterizations can potentially improve the global forecast and reanalysis of TC intensity.
Spectral Hardness of X‐ and Gamma‐Ray Emissions From Lightning Stepped and Dart Leaders
Authors: Contreras‐Vidal Luis , Sanchez James T. , da Silva Caitano L. , Sonnenfeld Richard G. , Aulich Graydon , Edens Harald E. , Eack Kenneth B. , Smith David M.
Published: April 2024

During the 2022 New Mexico monsoon season, we deployed two X‐ray scintillation detectors, coupled with a 180 MHz data acquisition system to detect X‐rays from natural lightning at the Langmuir Lab mountain‐top facility, located at 3.3 km above mean sea level. Data acquisition was triggered by an electric field antenna calibrated to pick up lightning within a few km of the X‐ray detectors. We report the energies of over 240 individual photons, ranging between 13 keV and 3.8 MeV, as registered by the LaBr3(Ce) scintillation detector. These detections were associated with four lightning flashes. Particularly, four‐stepped leaders and seven dart leaders produced energetic radiation. The reported photon energies allowed us to confirm that the X‐ray energy distribution of natural stepped and dart leaders follows a power‐law distribution with an exponent ranging between 1.09 and 1.96, with stepped leaders having a harder spectrum. Characterization of the associated leaders and return strokes was done with four different electric field sensing antennas, which can measure a wide range of time scales, from the static storm field to the fast change associated with dart leaders.
Impact of Atmospheric Compressibility and Stokes Drift on the Vertical Transport of Heat and Constituents by Gravity Waves
Authors: Gardner Chester S.
Published: April 2024

Vertical transport of heat and atmospheric constituents by gravity waves plays a crucial role in shaping the thermal and constituent structure of the middle atmosphere. We show that atmospheric mixing by non‐breaking waves can be described as a diffusion process where the potential temperature (KH) and constituent (KWave) diffusivities depend on the compressibility of the wave fluctuations and the vertical Stokes drift imparted to the atmosphere by the wave spectrum. KH and KWave are typically much larger than the eddy diffusivity (Kzz), arising from the turbulence generated by breaking waves, and can exceed several hundred m2s−1 in regions of strong wave dissipation. We also show that the total diffusion of heat and constituents caused by waves, turbulence, and the thermal motion of molecules, is enhanced in the presence of non‐breaking waves by a factor that is proportional to the variance of the wave‐driven lapse rate fluctuations. Diffusion enhancements of both heat and constituents of 50% or more can be experienced in regions of low atmospheric stability, where the lapse rate fluctuations are large. These important transport effects are not currently included in most global chemistry‐climate models, which typically only consider the eddy diffusion that is induced when the unresolved, but parameterized waves, experience dissipation. We show that the theoretical results compare favorably with observations of the mesopause region at midlatitudes and describe how the theory may be used to more fully account for the unresolved wave transport in global models.
Experimental Investigation on Scouring v.s. Mass Failure of Unsaturated Soil Bed: Implications for Debris Flow Initiation and Erosion
Authors: Song Pengjia , Yang Jun , Choi Clarence Edward , Zhang Jiaqi
Published: April 2024

Scouring and mass failure are two common mechanisms used to describe soil bed erosion, but their combined effects are often not considered. To better understand how these mechanisms compete and under what conditions they prevail, it is essential to consider infiltration and a more realistic unsaturated soil bed. This study investigates soil bed erosion by considering unsaturated soil mechanics, a wetting front, and both erosion mechanisms of scouring and mass failure. Physical experiments were conducted on model water runoff over an unsaturated sand bed to investigate the effects of soil water content and flow velocity on erosion. Experimental results show that current understanding of soil bed erosion can be enhanced by adopting unsaturated soil mechanics and considering the combined effects of scouring and mass failure. The scouring rate is found to be independent of the bed water content because it only affects the uppermost soil particles, which immediately become saturated once water flows over them. Mass failure, on the other hand, is initiated at the wetting front when the rate of infiltration exceeds that of scouring. The depth of mass failure can be described by the net infiltration depth, which is defined as the difference between the infiltration and scouring depths. The net infiltration depth is jointly governed by the soil water content and flow velocity. The crucial role of the coupled effects of the hydro‐mechanical behavior of unsaturated soil in the realistic modeling of soil bed erosion is demonstrated. Outcomes present advancement toward improved hazard assessments of debris flows.
Nowcasting Solar EUV Irradiance With Photospheric Magnetic Fields and the Mg II Index
Authors: Kniezewski Kara L. , Schonfeld Samuel J. , Henney Carl J.
Published: April 2024

A new method to nowcast spectral irradiance in extreme ultraviolet (EUV) and far ultraviolet (FUV) bands is presented here, utilizing only solar photospheric magnetograms and the Mg II index (i.e., the core‐to‐wing ratio). The EUV and FUV modeling outlined here is a direct extension of the SIFT (Solar Indices Forecasting Tool) model, based on Henney et al. (2015, https://doi.org/10.1002/2014sw001118). SIFT estimates solar activity indices using the earth‐side solar photospheric magnetic field sums from global magnetic maps generated by the ADAPT (Air Force Data Assimilative Photospheric Flux Transport) model. Utilizing strong and weak magnetic field sums from ADAPT maps, Henney et al. (2015, https://doi.org/10.1002/2014sw001118) showed that EUV & FUV observations can also be well modeled using this technique. However, the original forecasting method required a recent observation of each SIFT model output to determine and apply a 0‐day offset. The new method described here expands the SIFT and ADAPT modeling to nowcast the observed Mg II index with a Pearson correlation coefficient of 0.982. By correlating the Mg II model‐observation difference with the model‐observation difference in the EUV & FUV channels, Mg II can be used to apply the 0‐day offset correction yielding improvements in modeling each of the 37 studied EUV & FUV bands. With daily global photospheric magnetic maps and Mg II index observations, this study provides an improved method of nowcasting EUV & FUV bands used to drive thermospheric and ionospheric modeling.
Crustal‐Scale Pop‐Up Structure at the Junction of Two Continental‐Scale Deformation Zones in the Southern Baltic Sea
Authors: Ponikowska M. , Stovba S. M. , Mazur S. , Malinowski M. , Krzywiec P. , Nguyen Q. , Hübscher C.
Published: April 2024

The southern Baltic Sea is a peculiar area, where the Sorgenfrei‐Tornquist Zone (STZ), stretching from Bornholm into the North Sea, connects to the Teisseyre‐Tornquist Zone (TTZ) that continues SE up to the Black Sea. In this study, we show the structure and evolution of this controversially debated area, both on crustal and basin scale, by using three seismic reflection profiles combined with 2‐D potential field data. The results demonstrate that the southern Baltic Sea is underlain by a thick crust of the East European Craton with a Moho depth in the range of 38–42 km. The overall crustal architecture is shaped by three phases of localized stretching in the early Paleozoic, Devonian‐Carboniferous, and Permian‐Mesozoic. The most spectacular feature of the southern Baltic Sea is a zone of thick‐skinned compressional deformation produced by Late Cretaceous‐early Paleogene inversion, including a system of thrusts and back thrusts penetrating the entire crust in an 80–90 km wide inversion zone. ENE‐vergent thrusts are traced from the top of the Cretaceous down to the Moho and they are accompanied by back thrusts of opposite vergence, also reaching the Moho. Inversion tectonics resulted in the uplift of a block of cratonic crust as a pop‐up structure, bounded by thrusts and back thrusts, and the displacement of the Moho within the STZ and TTZ. The similar mechanism of intra‐cratonic inversion was recognized for the Donbas Foldbelt in eastern Ukraine, and it may be characteristic of rigid cratons, where deformation is localized in a few preexisting zones of weakness.
Distinct PM2.5‐Related Near‐Term Climate Penalties Induced by Different Clean Air Measures in China
Authors: Gao Da , Zhao Bin , Wang Shuxiao , Shen Jiewen , Wang Yuan , Zhou Chen , Jiang Jingkun , Wu Qingru , Li Shengyue , Sun Yisheng , He Yicong , Zhu Yun , Jiang Zhe
Published: April 2024

The reductions in aerosols often exacerbate climate warming. It remains unclear how to effectively alleviate PM2.5 pollution while minimizing the penalty on climate warming. Here we identify the clean air measures in China that are associated with low aerosol climate penalty efficiency (ACPE), which is defined as aerosol radiative forcing per unit PM2.5 concentration reduction. The measures in transportation, residential combustion, and open burning sectors generally caused lower ACPE [0.07, 0.24, and 0.10 (W m−2)/(μg m−3)] than those from other sectors [0.34–0.46 (W m−2)/(μg m−3)]. This is ascribed to relatively small decreases in cloud concentration nuclei per unit PM2.5 reduction in these sectors, which is further attributed to either relatively low aerosol hygroscopicity or relatively small decrease in aerosol number. Most measures in the former three sectors have low ACPE of <0.15 [(W m−2)/(μg m−3)] and thus may be prioritized for synergistically controlling PM2.5 pollution and climate warming.
Frequency‐Drifting Plasmaspheric Hiss: A Statistical Study From the Van Allen Probes Data
Authors: Yi Siyang , Liu Nigang , Xie Yi , He Zhaoguo , Yu Jiang , Cui Jun
Published: April 2024

Plasmaspheric hiss, a whistler‐mode emission confined in the high‐density plasmasphere, is of great interest to the space community attributed to its important role in inner magnetospheric dynamics. Their frequency‐time structures provide crucial evidence for understanding the wave origin. In this work, based on ∼7‐year Van Allen Probes data, we statistically studied the frequency‐drifting plasmaspheric hiss characterized by an increasing lower cutoff frequency over a timescale exceeding 1 hr. Frequency‐drifting hiss waves predominantly occur at 3 < L < 6 from predawn to noon during geomagnetic active times. Observations and theoretical analyses suggest the frequency‐drifting hiss could result from the local excitation inside the plasmasphere by energy‐dispersive injected electrons. This unique feature of plasmaspheric hiss waves serves, to a certain extent, as an “identifier” for discerning the wave origins and as a “marker” facilitating the link between hiss waves across a broad spatial range.
Expert consensus on pediatric orthodontic therapies of malocclusions in children
Authors: Zhou Chenchen , Duan Peipei , He Hong , Song Jinlin , Hu Min , Liu Yuehua , Liu Yan , Guo Jie , Jin Fang , Cao Yang , Jiang Lingyong , Ye Qingsong , Zhu Min , Jiang Beizhan , Ruan Wenhua , Yuan Xiao , Li Huang , Zou Rui , Tian Yulou , Gao Li , Shu Rui , Chen Jianwei , Liu Renkai , Zou Shujuan , Li Xiaobing
Published: April 2024

Malocclusion, identified by the World Health Organization (WHO) as one of three major oral diseases, profoundly impacts the dental-maxillofacial functions, facial esthetics, and long-term development of ~260 million children in China. Beyond its physical manifestations, malocclusion also significantly influences the psycho-social well-being of these children. Timely intervention in malocclusion can foster an environment conducive to dental-maxillofacial development and substantially decrease the incidence of malocclusion or reduce the severity and complexity of malocclusion in the permanent dentition, by mitigating the negative impact of abnormal environmental influences on the growth. Early orthodontic treatment encompasses accurate identification and treatment of dental and maxillofacial morphological and functional abnormalities during various stages of dental-maxillofacial development, ranging from fetal stages to the early permanent dentition phase. From an economic and societal standpoint, the urgency for effective early orthodontic treatments for malocclusions in childhood cannot be overstated, underlining its profound practical and social importance. This consensus paper discusses the characteristics and the detrimental effects of malocclusion in children, emphasizing critical need for early treatment. It elaborates on corresponding core principles and fundamental approaches in early orthodontics, proposing comprehensive guidance for preventive and interceptive orthodontic treatment, serving as a reference for clinicians engaged in early orthodontic treatment.
In vivo translocator protein in females with autism spectrum disorder: a pilot study
Authors: Tseng Chieh-En Jane , Canales Camila , Marcus Rachel E. , Parmar Anjali J. , Hightower Baileigh G. , Mullett Jennifer E. , Makary Meena M. , Tassone Alison U. , Saro Hannah K. , Townsend Paige Hickey , Birtwell Kirstin , Nowinski Lisa , Thom Robyn P. , Palumbo Michelle L. , Keary Christopher , Catana Ciprian , McDougle Christopher J. , Hooker Jacob M. , Zürcher Nicole R.
Published: April 2024

Sex-based differences in the prevalence of autism spectrum disorder (ASD) are well-documented, with a male-to-female ratio of approximately 4:1. The clinical presentation of the core symptoms of ASD can also vary between sexes. Previously, positron emission tomography (PET) studies have identified alterations in the in vivo levels of translocator protein (TSPO)—a mitochondrial protein—in primarily or only male adults with ASD, with our group reporting lower TSPO relative to whole brain mean in males with ASD. However, whether in vivo TSPO levels are altered in females with ASD, specifically, is unknown. This is the first pilot study to measure in vivo TSPO in the brain in adult females with ASD using [11C]PBR28 PET-magnetic resonance imaging (MRI). Twelve adult females with ASD and 10 age- and TSPO genotype-matched controls (CON) completed one or two [11C]PBR28 PET–MRI scans. Females with ASD exhibited elevated [11C]PBR28 standardized uptake value ratio (SUVR) in the midcingulate cortex and splenium of the corpus callosum compared to CON. No brain area showed lower [11C]PBR28 SUVR in females with ASD compared to CON. Test-retest over several months showed stable [11C]PBR28 SUVR across time in both groups. Elevated regional [11C]PBR28 SUVR in females with ASD stand in stark contrast to our previous findings of lower regional [11C]PBR28 SUVR in males with ASD. Preliminary evidence of regionally elevated mitochondrial protein TSPO relative to whole brain mean in ASD females may reflect neuroimmuno-metabolic alterations specific to females with ASD.
Risk of childhood neoplasms related to neonatal phototherapy- a systematic review and meta-analysis
Authors: Kuitunen Ilari , Nikkilä Atte , Kiviranta Panu , Jääskeläinen Johanna , Auvinen Anssi
Published: April 2024

Context

Observational studies have shown conflicting results as to whether exposure to neonatal phototherapy is associated with increased rates of childhood cancer.

Objective

To describe the rates of childhood neoplasms and cancer after neonatal phototherapy.

Data sources

The CENTRAL, PubMed, Scopus, and Web of Science databases.

Study selection

Observational studies regardless of design were included.

Data extraction

The data were extracted by one author and validated by another. The risk-of-bias assessment was performed using the ROBINS-E and Joanna Briggs Institute critical appraisal tools.

Results

Six cohort and 10 case-control studies were included. The overall risk of bias was high in seven and low in nine studies. In cohort studies, the odds ratio (OR) was increased for hematopoietic cancer (1.44; confidence interval [CI]: 1.16–1.80) and solid tumors (OR: 1.18; CI: 1.00–1.40). In case-control studies, the OR was 1.63 (CI: 0.99–2.67) for hematopoietic cancers and 1.18 (CI: 1.04–1.34) for solid tumors.

Conclusions

Children with a history of neonatal phototherapy had increased risk of hematopoietic cancer and solid tumors. The evidence quality was limited due to the high risk of bias and potential residual confounding.

Impact statement

Exposure to neonatal phototherapy increased later risk of hematopoietic cancer and solid tumors.

This is the most comprehensive study on the association between phototherapy and cancer, but the evidence quality was limited due risk of bias and residual confounding.

Future large scale well conducted studies are still needed to better estimate the association and.
α-Synuclein triggers cofilin pathology and dendritic spine impairment via a PrPC-CCR5 dependent pathway
Authors: Oliveira da Silva Marina I. , Santejo Miguel , Babcock Isaac W. , Magalhães Ana , Minamide Laurie S. , Won Seok-Joon , Castillo Erika , Gerhardt Ellen , Fahlbusch Christiane , Swanson Raymond A. , Outeiro Tiago F. , Taipa Ricardo , Ruff Michael , Bamburg James R. , Liz Márcia A.
Published: April 2024

Cognitive dysfunction and dementia are critical symptoms of Lewy Body dementias (LBD). Specifically, alpha-synuclein (αSyn) accumulation in the hippocampus leading to synaptic dysfunction is linked to cognitive deficits in LBD. Here, we investigated the pathological impact of αSyn on hippocampal neurons. We report that either αSyn overexpression or αSyn pre-formed fibrils (PFFs) treatment triggers the formation of cofilin-actin rods, synapse disruptors, in cultured hippocampal neurons and in the hippocampus of synucleinopathy mouse models and of LBD patients. In vivo, cofilin pathology is present concomitantly with synaptic impairment and cognitive dysfunction. Rods generation prompted by αSyn involves the co-action of the cellular prion protein (PrPC) and the chemokine receptor 5 (CCR5). Importantly, we show that CCR5 inhibition, with a clinically relevant peptide antagonist, reverts dendritic spine impairment promoted by αSyn. Collectively, we detail the cellular and molecular mechanism through which αSyn disrupts hippocampal synaptic structure and we identify CCR5 as a novel therapeutic target to prevent synaptic impairment and cognitive dysfunction in LBD.
STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells
Authors: Wang Ling , Liang Zhaoduan , Guo Yunzhuo , Habimana Jean de Dieu , Ren Yuefei , Amissah Obed Boadi , Mukama Omar , Peng Siqi , Ding Xuanyan , Lv Linshuang , Li Junyi , Chen Min , Liu Zhaoming , Huang Rongqi , Zhang Yinchao , Li Yi , Li Zhiyuan , Sun Yirong
Published: April 2024

Antigen-specific T cell receptor-engineered T cell (TCR-T) based immunotherapy has proven to be an effective method to combat cancer. In recent years, cross-talk between the innate and adaptive immune systems may be requisite to optimize sustained antigen-specific immunity, and the stimulator of interferon genes (STING) is a promising therapeutic target for cancer immunotherapy. The level of expression or presentation of antigen in tumor cells affects the recognition and killing of tumor cells by TCR-T. This study aimed at investigating the potential of innate immune stimulation of T cells and engineered T cells to enhance immunotherapy for low-expression antigen cancer cells. We systematically investigated the function and mechanism of cross-talk between STING agonist diABZI and adaptive immune systems. We established NY-ESO-1 full knockout Mel526 cells for this research and found that diABZI activated STING media and TCR signaling pathways. In addition, the results of flow cytometry showed that antigens presentation from cancer cells induced by STING agonist diABZI also improved the affinity of TCR-T cells function against tumor cells in vitro and in vivo. Our findings revealed that diABZI enhanced the immunotherapy efficacy of TCR-T by activating STING media and TCR signaling pathways, improving interferon-γ expression, and increasing antigens presentation of tumor cells. This indicates that STING agonist could be used as a strategy to promote TCR-T cancer immunotherapy.
FBXL8 inhibits post-myocardial infarction cardiac fibrosis by targeting Snail1 for ubiquitin-proteasome degradation
Authors: Li Ya , Zuo Caojian , Wu Xiaoyu , Ding Yu , Wei Yong , Chen Songwen , Lu Xiaofeng , Xu Juan , Liu Shaowen , Zhou Genqing , Cai Lidong
Published: April 2024

Abnormal cardiac fibrosis is the main pathological change of post-myocardial infarction (MI) heart failure. Although the E3 ubiquitin ligase FBXL8 is a key regulator in the cell cycle, cell proliferation, and inflammation, its role in post-MI ventricular fibrosis and heart failure remains unknown. FBXL8 was primarily expressed in cardiac fibroblasts (CFs) and remarkably decreased in CFs treated by TGFβ and heart subjected to MI. The echocardiography and histology data suggested that adeno-associated viruses (AAV9)-mediated FBXL8 overexpression had improved cardiac function and ameliorated post-MI cardiac fibrosis. In vitro, FBXL8 overexpression prevented TGFβ-induced proliferation, migration, contraction, and collagen secretion in CFs, while knockdown of FBXL8 demonstrated opposite effects. Mechanistically, FBXL8 interacted with Snail1 to promote Snail1 degradation through the ubiquitin–proteasome system and decreased the activation of RhoA. Moreover, the FBXL8ΔC3 binding domain was indispensable for Snail1 interaction and degradation. Ectopic Snail1 expression partly abolished the effects mediated by FBXL8 overexpression in CFs treated by TGFβ. These results characterized the role of FBXL8 in regulating the ubiquitin-mediated degradation of Snail1 and revealed the underlying molecular mechanism of how MI up-regulated the myofibroblasts differentiation-inducer Snail1 and suggested that FBXL8 may be a potential curative target for improving post-MI cardiac function.