bluuebunny/crossref_metadata_2025 huggingface dataset:
​In vitro Acaricidal Activity and Phytochemical Screening of Calotropis gigantea Flowers against Riphicephalus microplus
Authors: Dalei M.K. , Dehuri M. , Mohanty B.N. , Palai S. , Kuppusamy S.
Published: June 2022

Background: Tick infestation particularly, of Riphicephalus microplus is a costly affair for farmers particularly in times of emerging resistance. Biological control using plant extracts will serve as environment friendly and cost-effective method. The present study was taken up to investigate the phytoconstituents and acaricidal activities of ethanolic extract of Calotropis gigantea flowers. Methods: The acaricidal efficacy of ethanolic extracts of Calotropis gigantea flowers against engorged adult females of R. microplus were accessed by measuring mortality, inhibition of oviposition, hatching rate and larval mortality through Adult Immersion and Larval Packet Test. Gas chromatography-Mass spectrometry (GC-MS) analysis was done to reveal various compounds found in the flowers of Calotropis gigantea to justify their acaricidal activity. Result: As per the results of the in vitro tests (adult immersion test and larval packet test), there was adult mortality of 56.67%, RI of 0.17, IO of 66% and larval mortality of 60.33% at concentration of 100 mg/ml. LC50 values were found to be 83.18 mg/ml. The GC-MS analysis revealed the presence of two major phytocompounds: dibutyl phthalate and n-Hexadecanoic acid in the extracts suggesting potential acaricidal properties. Results of the present study revealed the ethanolic extracts of Calotropis gigantea flower have potential anti-tick activity against both larval and adult stage of Rhipicephalus microplus.
Characterization and Molecular Identification of Bacteria Isolated from Raw Camel’s Milk in Al-Ahsa, Saudi Arabia
Authors: Khalifa Ashraf , Almalki Mohammed
Published: June 2022

Background: Camel’s milk has many benefits on human health, however, drinking fresh untreated camel’s milk may pose a serious health concern. Therefore, the current study aimed to determine the bacteriological quality of raw camel’s milk by isolating, characterizing and identifying bacterial strains from the untreated milk in Al-Ahsa region, Saudi Arabia. Methods: Three raw milk samples were collected under aseptic conditions and bacterial counts were determined using the serial dilution plate method. Discrete colonies were picked based on morphological differences. Five representative bacterial strains were characterized by phenotypic analysis, biochemical tests using the API 20E system and sequencing of 16S rRNA genes. Result: The results showed that the total bacterial counts in camel’s milk reached 3 × 107 CFU mL-1, which exceeds the limit specified by the Saudi Food and Drug Authority. The isolates formed colonies that were rounded, entire, convex and elevated from the surface of the agar. The diameter of the colonies ranged from 1 to 4 mm after a 48-h incubation at 30°C on the M17 medium. The isolates were able to metabolize 12 (60%) to 15 (75%) out of 20 different compounds as growth substrates present in the API 20E test system. Additionally, BLAST analysis of the 16S rRNA sequences of the five bacterial isolates revealed that they were closely related to various known bacterial genera (e.g., Bacillus, Kocuria and Pseudomonas), indicating the diverse composition of the microflora in raw camel’s milk. Unlike the other four bacterial isolates, a clear zone was noted around the growing one bacterial isolate, CMK1, highlighting a remarkable degradation of the hemoglobin in the erythrocytes, highlighting the potential existence virulence determinants. Good hygiene practices during milk production and handling are recommended to ensure high raw milk quality and avoid health risks. This study sheds light on the bacterial diversity of raw camel’s milk that has a direct impact on public health and the economy.
MMPI-2-RF Differences Between Violent Offending and Institutional Violence Among Incarcerated Women
Authors: Gottfried Emily D. , Mulay Abby L. , Schenk Allison M. , Vitacco Michael J.
Published: June 2022

The examination of violence perpetrated by female offenders remains an understudied topic, as research typically focuses on male offender samples. As such, it remains unclear what personality characteristics may be associated with the perpetration of violence among female offenders. This study sought to examine the relationship between personality characteristics, as assessed by the MMPI-2-RF, and engagement in violence, within a sample of 228 incarcerated women. Results indicated that women serving time for a violent offense obtained higher mean scores on MMPI-2-RF scales related to underreporting, atypical thoughts/experiences, and paranoia. Women who obtained disciplinary reports for violence within the institution obtained higher mean scores on MMPI-2-RF scales related to behavior/externalizing dysfunction, overactivation, and aggression. Taken together, violence was most strongly associated with the MMPI-2-RF scales related to paranoia and atypical thoughts/experiences (e.g., THD, PSYC-r). This study provides new data on the viability of the MMPI-2-RF to provide critical insights into violent and aggression behavior in female inmates, an understudied population and demonstrate the instrument’s efficacy in assessing characteristics associated with violent behavior.
The Application Process for the Unknown Victim’s Identification in Cold Cases using Forensic DNA Techniques
Authors:   The Korean Academy of Scientific Criminal Investigation, Cho Nam Soo , Nam Younhyoung
Published: June 2022

The usage of forensic DNA techniques to trace biological kinship is a very important process in identifying unknown deceased victims in unsolved murder cases. In most contexts, DNA collection to investigate unknown persons’ cases is entrusted to authorities under the assumption that the case may be a murder, an unnatural death or other crime. Short tandem repeats (STRs), single nucleotide polymorphisms (SNPs), and mitochondrial DNA analyses are three classes of markers which will play an important role in the present and the future of forensic DNA typing. Furthermore, the combination of Y-STRs and Y-SNPs provides valuable investigative leads on the geographical ancestry of the male trace donor. The mitochondrial DNA is highly polymorphic and can also provide statistical inferences of a DNA donor’s bio-geographical ancestry. In the case of unresolved murder, identification of unknown victim provides a clue to a very important case resolution. Therefore, we need to discuss the use forensic DNA information to identify for unknown victims of unnatural death related to murder cases.
Regarding the Current Status of Addictive Suicide in Busan and the Improvement of Problems Arising from Field Investigations
Authors:   The Korean Academy of Scientific Criminal Investigation, Yu Gyeong-Jin , Song Ye-Eun , Jung Jae-bong , Kim Na-Jin , Kwak Dae-Hoon
Published: June 2022

As a result of analysis for 1091 cases classified as suicide by addiction from the unnatural death cases registered on Scientific Crime Analysis System (SCAS) of Busan Metropolitan Police from January 2014 to December 2020, almost of them have shown similar aspects to the data from Statistics Korea. But it was not only investigated that the rate of cases where causes for suicides cannot be known is high as 63.6% in average, but also shown that in proofs of fields and examination, there are high rates of being not written (excluding gas addiction). Meanwhile, unlike gas addiction that various proofs of fields and examination are found showing a low rate of blood collection (4.5%), poison addiction and drug addiction have shown a somewhat high rate of blood collection but in general, a low rate of it (27.7%). To solve such problems, it is needed to establish a field identification system which can share materials for field identification or can complement them by integrating. Furthermore, it is thought that not to occur differences in the SCAS records by people writing them, the standardized writing method is needed, and that from a viewpoint of collecting proofs, seeking ways to boost drawing blood and, simultaneously, discussing about subjects for blood collection are needed.
Initial assessment of hemorrhagic shock by trauma computed tomography measurement of the inferior vena cava in blunt trauma patients
Authors: Lee Gun Ho , Choi Jeong Woo
Published: June 2022

Purpose: Inferior vena cava (IVC) collapse is related to hypovolemia. Sonography has been used to measure the IVC diameter, but there is variation depending on the skill of the operator and it is difficult to obtain accurate measurements in patients who have a large amount of intestinal gas or are obese. As a modality to obtain accurate measurements, we measured the diameters of the IVC and aorta on trauma computed tomography scans and investigated the correlation between the IVC to aorta ratio and the shock index in blunt trauma patients.Methods: We retrospectively analyzed the medical records of 588 trauma patients who were transferred to the regional trauma center (level 1) of Wonkang University hospital from March 2020 to February 2021. We included trauma patients 18 years or older who met the trauma activation criteria and underwent trauma computed tomography scans with intravenous contrast within 40 minutes of admission. The shock index was calculated from vital signs before trauma computed tomography scan, and measurements of the anteroposterior diameter of the IVC (AP), the transverse diameter of the IVC (T), and aorta were made 10 mm above the right renal vein in the venous phase.Results: Overall, 271 patients were included in this study, of whom 150 had a shock index ≤0.7 and 121 had a shock index >0.7. The T to AP ratio and AP to aorta ratio were significantly different between groups. Cutoffs were identified for the T to AP ratio and AP to aorta ratio (2.37 and 0.62, respectively) that produced clinically useful sensitivity and specificity for predicting a shock index >0.7, demonstrating moderate accuracy (T to AP ratio: area under the curve, 0.71; sensitivity, 59%; specificity, 87% and AP to aorta ratio: area under the curve, 0.70; sensitivity, 55%; specificity, 91%).Conclusions: The T to AP ratio and AP to aorta ratio are useful for predicting hemorrhagic shock in trauma patients.
Prematuridade em Foco: Estudo Descritivo e Correlacional
Authors: Pereira Veronica Aparecida , Mathias Betania Moura , Moreira Amanda Marques
Published: June 2022

Este estudo buscou: a) descrever e correlacionar as ocorrências de partos prematuros em um hospital universitário de Mato Grosso do Sul, no período de um ano; e b) descrever os sentimentos relatados pelas mães durante a internação. Foram visitadas 1.532 mães, sendo 283 com parto prematuro. As mães de bebês pré-termo internados após o parto foram convidadas a responder um questionário sobre os sentimentos gerados pela internação e 25 aceitaram. Os dados foram analisados por estatística descritiva e correlação de Spearman. A prevalência de prematuridade foi de 18,5%, sendo superior ao indicado pela Organização Mundial da Saúde (OMS). A idade materna mais elevada esteve correlacionada à maior ocorrência de prematuridade e cesariana. A maioria das participantes relatou sentimentos negativos antes e durante a internação, contudo, elas apresentam expectativas positivas após a alta.
“I’m Here for You”: Understanding the Caring Role of Nurse Preceptor in Patient Safety
Authors: Alfahd Hanan , Longo Joy
Published: June 2022

Background:

Nurse preceptors assume many responsibilities, including facilitating the learning experience of novice nurses while ensuring safe practices. Understanding the nurse preceptors’ experience will provide a baseline for raising safety awareness among nurses. Methods: A directed content analysis design was used. The initial categories were based on predetermined categories of Roach’s six C’s. Results: Analysis of the data led to the following six categories: recognizing the uniqueness of others, Building Competence for Patient Safety, establishing relationships, preceptor intentionality, promoting collaboration, and being a role model. Conclusion: The results of the study demonstrate the preceptors’ ability to balance their roles in delivering safe care while precepting new staff. They efficiently used their experience and caring attributes to facilitate the learning process.
Women Support Women: How Coastal Women in Demak Step Out from Poverty
Authors: Nastabilla Diandra Masayu , Prakoso Raihan Yogi , Alhafizh Raihan Yahya
Published: June 2022

According to research carried out by the Central Java provincial government in 2019, there are 13,415 poor people in the Demak Regency coastal area, where most people are fishers. The unstable income and the tendency of a consumer lifestyle followed by the weakness in money management are the main factors of poverty. Moreover, the covid-19 pandemic also aggravated the poverty of the coastal communities of the Demak Regency. Unfortunately for the coastal communities of the Demak Regency, the role of women is less significant because of the dominance of roles and cultural trends of patriarchy by men. Based on this, the coastal women there initiated a Women Support Women movement. This study used qualitative descriptive methods and a series of interviews and observations in its data retrieval. This study focused on identifying the form of the movement and explaining the impact on coastal women in Demak Regency to break out of the cycle of poverty and patriarchal culture. The results showed that the Women Support Women movement consists of individuals to the community, community to individuals, and community to community. There are three main actors in this movement: Forum Demak Hijau, Puspita Bahari, and Mrs. Pasijah. With this movement, coastal women in Demak Regency are proven to be able to contribute financially to their families, decreasing the patriarchal culture, and creating a trickle-down effect on others.
The Effect of HDI and Macroeconomic Variables on Economic Growth in Indonesia 2015-2020
Authors: Soleman Riky , Ebiyeska Hedi , Wibowo Muhammad Ghafur , Nainggolan Basaria
Published: June 2022

The Human Development Index (HDI) measures the achievement of human development based on several basic components of quality of life. HDI is built through a basic three-dimensional approach to measure the quality of life. These dimensions include life expectancy and health, knowledge, and a decent life. Stable inflation is a prerequisite for the realization of economic growth and social welfare. Different economic conditions and natural conditions make inflation between regions in Indonesia varied. This study aims to examine HDI, inflation, investment and labor on Indonesia’s economic growth. The data source used in the form of panel data that obtained from the Badan Pusat Statistik (BPS) for the 2015-2020 period. Using panel regression data with the Common Effect Model (CEM), Fixed Effect Model (FEM), and Random Effect Model (REM) approach processed with E-Views 10. The results of this study indicate that the estimated model chosen in this study is Fixed Effect Models (FEM). The partial test shows that the HDI, CPI, and INV variables have a significant positive effect on economic growth. In contrast, the probability value of labor (L) does not have a significant effect on economic growth. Meanwhile, in the simultaneous test, the F-statistic probability value is 0.000000 < 0.05, which means that the four independent variables simultaneously affect economic growth. Furthermore, the Adjusted R-Square value is 0.0994749, which means 99% of the HDI, CPI, INV, and L variables in this study can explain the variation of economic growth variables. While the remaining 1% is explained by other variables outside the model.
Creative Industry and Economic Recovery Strategies from Pandemic Disruption
Authors: Santoso Rudi , Fianto Achmad Yanu Alif
Published: June 2022

This study aims to present a critical review of how economic and financial theory is used as a solution to rise from economic downturn during the pandemic. This article will present the implementation of economic policies and approaches from various countries in the Southeast Asia region in responding to the crisis during the pandemic. This research approach uses an exploratory qualitative research model. The results of this study present and provide an analysis of an event, thought, phenomenon, individual perception, and social activity in responding to a crisis. This study found a uniform approach used by various countries regarding economic recovery policies. Financial stimulus is given to the Small and Medium Enterprises (MSME) sector to revive an economy that is experiencing difficulties. This study also finds a similar pattern related to financial stimulus policies in 6 (six) important sectors. These efforts include: creative industri incentives, road maps, training, and partnerships with investors for development.
Ebbs and Flows of Securities Fraud Litigation: Empirical Examination of Post-PSLRA Frequency & Severity Trends
Authors: Banasiewicz Andrew
Published: June 2022

The separation of ownership and management that characterizes modern business corporations frequently gives rise to a conflict of interest known as agency dilemma. A manifestation of information asymmetry between organizational decision-makers – i.e., corporate directors and officers – and organizational owners/investors, that discord can spur formal allegations of incorrect, incomplete, misleading, or untimely management disclosures, ultimately leading to securities fraud litigation or simply shareholder litigation. For companies with distributed ownership spread across thousands of individual and institutional investors, securities lawsuits commonly encompass large pools or ‘classes’ of shareholders jointly pursuing their claims seeking financial compensation for management misinformation-caused losses; not surprisingly, those class actions stand out as one of the most economically and reputationally damaging manifestations of organizational risk. The research summarized here offers empirical assessment of the 25 years of securities class action filings and settlements that followed the passage of the seminal legislative act, the Private Securities Litigation Reform Act of 1995, yielding a number of unexpected shareholder litigation incidence and cost related conclusions.
SSCB’DEN RUSYA FEDARASYONU’NA TÜRK-RUS İLİŞKİLERİ: İMKANLAR VE AÇMAZLAR
Authors: KİŞİ Erden
Published: June 2022

Bilindiği üzere Osmanlı Devleti’nden bugüne Türk-Rus ilişkileri her dönem varlığını korumuştur. Osmanlı’nın en çok savaştığı devlet olması hasebiyle iki toplum arasında yoğun bir ilişki ağı olduğu görülmektedir. Türkler ve Ruslar arasındaki ilişkilerin Çarlık Rusyası’ndan SSCB’ye oradan da Rusya Federasyonu’na kadar yoğun bir şekilde ilerlediği anlaşılmaktadır. Orta Asya’dan Kafkasya’ya ve oradan da Balkanlar’a kadar iki ülke arasında yoğun bir ilişki ağının olduğu da görülmektedir. 20. yüzyıla gelindiğinde ise iki ülke ilişkileri daha farklı bir boyuta ulaşmıştır. Bu süreçte hem Ruslar hem de Türklerin önemli bir devrim yaşaması ile iki ülke ilişkilerinde daha farklı bir sayfa açılmıştır. Daha sonrasındaki süreçte ise Soğuk Savaş’ın başlamasıyla Türkiye ve SSCB ilişkilerinde bir soğuma olduğu anlaşılmaktadır. Soğuk Savaş’ın ardından SSCB’nin tarih sahnesinden silinip Rusya Federasyonu’nun kurulması ile daha farklı bir sürece geçilmiştir. 2000’li yıllar sonrasında ise Türkiye ve Rusya’nın gerek Orta Doğu’da gerek Kafkasya’da gerek Orta Asya’da gerekse de Balkanlar’da ilişkilerinin olduğu görülmüştür. Bu çalışmada derin bir mazisi olan Türk-Rus ilişkilerinin geçmişi, şimdiki yapısı ve gelişeceği yön anlaşılmaya çalışılacaktır. İki ülke arasındaki ilişkilerin sosyo-politik bir analizi yapılarak, 21. yüzyılda iki ülke ilişkilerinde hâkim olan siyasal anlayış açıklanacaktır. En nihayetinde ise gelecek dönemde iki ülke arasındaki ilişkilerin gelişeceği yön ve tarz üzerine ortaya atılan görüşler tartışılacaktır.
Recent advances and perspectives of microsized alloying-type porous anode materials in high-performance Li- and Na-ion batteries
Authors: Li Gaojie , Guo Siguang , Xiang Ben , Mei Shixiong , Zheng Yang , Zhang Xuming , Gao Biao , Chu Paul K. , Huo Kaifu
Published: June 2022

Alloying materials (e.g., Si, Ge, Sn, Sb, and so on) are promising anode materials for next-generation lithium-ion batteries (LIBs) and sodium-ion batteries (SIBs) due to their high capacity, suitable working voltage, earth abundance, environmental friendliness, and non-toxicity. Although some important breakthroughs have been reported recently for these materials, their dramatic volume change during alloying/dealloying causes severe pulverization, leading to poor cycling stability and safety risks. Although the nanoengineering of alloys can mitigate the volumetric expansion to some extent, there remain other drawbacks, such as low initial Columbic efficiency and volumetric energy density. Porous microscale alloys comprised of nanoparticles and nanopores inherit micro- and nanoproperties, so that volume expansion during lithiation/sodiation can be better accommodated by the porous structure to consequently release stress and improve the cycling stability. Herein, the recent progress of porous microscale alloying-type anode materials for LIBs and SIBs is reviewed by summarizing the Li and Na storage mechanisms, the challenges associated with different materials, common fabrication methods, and the relationship between the structure and electrochemical properties in LIBs and SIBs. Finally, the prospects of porous microscale alloys are discussed to provide guidance for future research and the commercial development of anode materials for LIBs and SIBs.
STEMIN and YAP5SA synthetic modified mRNAs regenerate and repair infarcted mouse hearts
Authors: Xiao Siyu
Published: June 2022

Introduction: The adult heart lacks the regenerative capacity to self-repair. Serum response factor (SRF) is essential for heart organogenesis, sarcomerogenesis, and contractility. SRF interacts with co-factors, such as NKX2.5 and GATA4, required for cardiac specified gene activity. ETS factors such as ELK1 interact with SRF and drive cell replication. To weaken SRF interactions with NKX2.5 and GATA4, one mutant, SRF153(A3) named STEMIN, did not bind CArG boxes, yet induced stem cell factors such as NANOG and OCT4, cardiomyocyte dedifferentiation, and cell cycle reentry. The mutant YAP5SA of the Hippo pathway also promotes cardiomyocyte proliferation and growth. Aim: Infarcted adult mouse hearts were injected with translatable STEMIN and YAP5SA mmRNA to evaluate their clinical potential, Methods and Results: Mice were pulsed one day later with alpha-EDU and then heart sections were DAPI stained. Replicating cells were identified by immuno-staining against members of the DNA replisome pathway that mark entry to S phase of the cell cycle. Echocardiography was used to determine cardiac function following infarcts and mRNA treatment. To monitor cardiac wall repair, microscopic analysis was performed, and the extent of myocardial fibrosis was analyzed for immune cell infiltration. Injections of STEMIN and YAP5SA mmRNA into the left ventricles of infarcted adult mice promoted a greater than 17-fold increase in the DAPI stained and alpha-EDU marked cardiomyocyte nuclei, within a day. We observed de novo expression of phospho-histone H3, ORC2, MCM2, and CLASPIN. Cardiac function was significantly improved by four weeks post-infarct, and fibrosis and immune cell infiltration were diminished in hearts treated with STEMIN and YAP5SA mmRNA than each alone. Conclusion: STEMIN and YAP5SA mmRNA improved cardiac function and myocardial fibrosis in left ventricles of infarcted adult mice. The combinatorial use of mmRNA encoding STEMIN and YAP5SA has the potential to become a powerful clinical strategy to treat human heart disease.
A Quantum Space Model of Cosmic Evolution: Dark Energy and the Cyclic Universe
Authors: Melendres Carlos A.
Published: June 2022

We present a Quantum Space Model (QSM) of the evolution of the universe based on the theory that space consists of energy quanta from which it began. We used the Friedmann equations to trace its history and show that Dark Energy is the energy of space which caused its accelerating expansion.The universe started from a quanta of space which was triggered by quantum fluctuations that caused the Big Bang. It then expanded and cooled undergoing phase transitions to radiation, fundamental particles, and matter. Matter grew into galaxies, and was consolidated by gravity into Black Holes, ending in a Big Crunch and Deep Freeze inside a Black hole at 1.380 trillion years. Fluctuations caused a new Bang to start another cycle in its life. If the Law of Conservation of Energy is universal, then the cosmos is eternal. Our results support the theoretical predictions of a cyclic universe by Steinhardt and associates, as well as Penrose. Space and energy are equivalent as embodied in the Planck energy equation. They are the two most fundamental quantities that govern cosmic evolution. The two principal long range forces are the gravitational force and the space force,which maybe the fifth force in the universe. They provide the clockwork mechanism operating our cyclic universe.
Analysis of Perception, Reasons, and Motivations for COVID-19 Vaccination in People with Diabetes across Sub-Saharan Africa: A Mixed-Method Approach
Authors: Osuagwu Uchechukwu Levi , Langsi Raymond , Ovenseri-Ogbomo Godwin , Mashige Khathutshelo Percy , Abu Emmanuel Kwasi , Envuladu Esther Awazzi , Goson Piwuna Christopher , Ekpenyong Bernadine Nsa , Oloruntoba Richard , Chundung Miner Asabe , Charwe Deborah Donald , Timothy Chikasirimobi Goodhope , Ishaya Tanko , Amiebenomo Onyekachukwu Mary-Anne , Lim David , Agho Kingsley E
Published: June 2022

Abstract: Diabetes mellitus (DM) is associated with severe COVID-19 infection and complications. This study assessed COVID-19 vaccine acceptance and hesitancy in diabetes and explored reasons for nonvaccinating. This was a web-based cross-sectional survey using a mixed-method approach conducted between March-May 2021 corresponding to most SSA countries' early vaccine rollout period. Participants were those aged ≥18 years with self-reported DM in 11 Sub-Saharan African (SSA) countries. Responses to comments on reasons for vaccine hesitancy and facilitators for vaccine uptake were analyzed. Of the 73 participants with DM, 65.8% were males older than 35 years (86.3%), had post-secondary education (90%), and a significant proportion was from South Africa (39.7%), Nigeria (28.8%) and Ghana (13.7%). 64.4% had COVID-19 symptoms, 46.6% were tested for COVID-19, of which 19.2% tested positive. Few participants (6.8%) had taken the COVID-19 vaccination, 65.8% were willing to take the vaccine, while 26.0% either refused or hesitated to take the vaccine. The main reasons identified for not taking the vaccine were: advice from religious leaders, concerns about the vaccine safety, its effects, and efficacy, mistrust of the pharmaceutical companies, the conspiracy theories around the vaccines, the process of production, and the personal belief of the participants. However, participants stated they would take the vaccine if given more education about it, receive positive feedback from those vaccinated, are rewarded for taking the vaccine or if vaccination becomes a condition for travel and employment. The findings of this study showed that uptake of the COVID-19 vaccine was very low in this high-risk group. It is imperative that efforts to increase the uptake of vaccines, such as the provision of education and relevant information, are made.
Combining Log Files and Monitoring Data to Detect Anomaly Patterns in a Data Center
Authors: Viola Laura , Ronchieri Elisabetta , Cavallaro Claudia
Published: June 2022

Context: Anomaly detection in a data center is a challenging task, having to consider different services on various resources. Current literature shows the application of artificial intelligence techniques to either log files or monitoring data: the former created by services at run time, while the latter produced by specific sensors directly on the physical or virtual machine.
Objectives: We propose a model that exploits information both in log files and monitoring data to identify patterns and detect anomalies over time.
Methods: The key idea is to use on one side natural language processing solutions to detect problems at service level, extracting words that represent anomalies. Clustering and topic modeling techniques have been used to identify patterns and group them with respect to topics. On the other side time series anomaly detection technique has been applied to sensors data in order to combine problems found in the log files with problems stored in the monitoring data.
Results: We have tested our approach on a real data center equipped with log files and monitoring data that can characterize the behaviour of physical and virtual resources in production. We have observed a correspondence between anomalies in log files and monitoring data, e.g. an increase in memory usage or machine load. The results are extremely promising.
Conclusion: Our model requires to integrate site administrators' expertise in order to consider all critical scenario in the data center and understand results properly.
Recombinant BoHV-5 Glycoprotein Elicits Long-Lasting Protective Immunity in Cattle
Authors: Araujo Itauá Leston , Piraine Renan Eugênio Araujo , Fischer Geferson , Leite Fábio Pereira Leivas
Published: June 2022

Bovine herpesvirus (BoHV)-5 is a worldwide distributed pathogen usually associated with a lethal neurological disease (meningoencephalitis) in dairy and beef cattle resulting in important economic losses due to the cattle industry. Using recombinant glycoprotein D of BoHV-5 (rgD5), we evaluated the long-duration humoral immunity of the recombinant vaccines in a cattle model. Here we report that two doses of intramuscular immunization, particularly with the rgD5ISA vaccine, are superior to iBoHV-5ISA immunization in the induction of long-lasting antibody responses. Recombinant gD5 antigen elicited tightly mRNA transcription of the Bcl6 and the chemokine receptor CXCR5 which mediate memory B cells and long-lived plasma cells in germinal centers (GCs). In addition, using an in-house Enzyme-Linked Immunosorbent Assay (ELISA) we observed higher and earlier responses of rgD5-specific IgG antibody and the upregulation of mRNA transcription of IL2, IL4, IL10, IL15 and IFN-γ cytokines in rgD5 vaccinated cattle, indicating a mixed immune response. We further show that rgD5 immunization provides protection against both BoHV -1 and -5. Our findings indicate that the rgD5-based vaccine represents an effective vaccine strategy to induce an efficient control of alpha-herpesviruses.
Microbiological Safety of Fresh-Cut Produce and Salads Served at Quick Service Restaurants
Authors: Shahbaz Muhammad , Moiz Abdul , Zubair Shagufta , Bilal Muhammad
Published: June 2022

The consumption and sale of fresh-cut products and salads have been growing tremendously in the present era. Therefore, the microbial safety of such products is of great concern. In the current study, a survey of general microbiological safety of fresh-cut produce and salads at quick-service restaurants (QSR) was undertaken across the Kingdom of Saudi Arabia. These findings were compared with microbiological criteria for foodstuffs by Saudi standards, metrology, and quality organization SASO-GSO-1016. Of the 82 samples of fresh-cut produce, 7% of samples were found to be unsatisfactory or beyond the acceptable limits. TPC count was unsatisfactory at 22%, coliform at 48%, and Staphylococcus aureus at 4%. For 108 samples for fresh salads, 11% of samples were found to be unsatisfactory or beyond the acceptable limits,13%, 27%, 4%, and 27% of samples showed an unsatisfactory range of TPC, coliforms, S. aureus, and Escherichia coli, respectively. The fresh-cut produce and salads were microbiologically safe in the central region compared to the eastern region followed by the western region. The relatively higher count was found in green pepper, mixed vegetables, and lettuce followed by fresh-cut onions and coleslaw salads. No Salmonella was detected in both fresh-cut produce and salads. The restaurants should be more stringent in their processing to ensure the consumer safety. Washing and sanitization of produce is the only way to reduce the diffusion of food borne pathogens.
Mustafa bin Muhammed Ankaravî’nin İki Münâcâtı
Authors: SONMEZ Faruk
Published: June 2022

Türklerin İslamiyet’i kabulünden sonra, Türk edebiyatına yeni türler girmeye başlamıştır. Türk şairleri, Cenâb-ı Allah, Hz. Muhammed ve Kur’ân-ı Kerim başta olmak üzere İslam kültürü ile ilgili çok sayıda eser meydana getirmişlerdir. Bu eserler içerisinde yukûnu Yüce Allah’ın konu edildiği birçok tür meydana getirilmiştir. Bu türlerin başında; kulun acizliğini, günâhkarlığını bilip Allah’tan af ve inayet dilemesini konu edinen münâcâtlar gelir. Çoğu divan ve mesnevilerin başında birer şiir olarak bulunan bu türün, nadir de olsa müstakil halde yazılmış olanları da mevcuttur. Çalışmaya konu olan iki münâcât, şairin Hulvü’n- Nâsıhîn adlı mensur eserinin başında ve sonunda bulunmaktadır.

Bu çalışmada, Mustafa bin Muhammed Ankaravî’nin hayatı, şahsiyeti ve eserleri hakkında bilgi verilmiştir. Konunun esasını oluşturan; Ankara Millî Kütüphane 06 Mil Yz A 8091 numarada kayıtlı yazmanın 3b ile 101b-102a varakları arasında kayıtlı olan iki münâcât çeşitli hususiyetler bakımından incelenmiştir.
Parámetros nutricionales como predictores de efectos adversos en pacientes adultos mayores varones con cáncer en el Centro Médico Naval
Authors:   , Gil Martinez Maria Pia , Vilca Vasquez Katya Alexandra
Published: June 2022

Antecedentes: El cáncer ha pasado a ser la principal causa de muerte en todo el mundo, por ello es importante evaluar aquellos factores que intervienen en los tratamientos antineoplásicos que generen que se presenten efectos adversos, basados en ello, el análisis de parámetros nutricionales en estos pacientes podría ser la clave que lleve a un mejor direccionamiento en el manejo del paciente con neoplasias. Objetivo: Establecer la asociación entre parámetros nutricionales y reacciones adversas al tratamiento antineoplásico en pacientes varones adultos mayores. Metodología: El presente estudio fue de tipo retrospectivo observacional, analítico. Analizamos secundariamente una base de datos de un estudio de adultos varones mayores atendidos en el Centro Médico Naval con diagnóstico de cáncer. Exploramos las variables nutricionales como dosaje de albúmina, IMC, baja de peso, circunferencia de pantorrilla como factores nutricionales, para evaluar si predicen efectos adversos al tratamiento antineoplásico en la población descrita. Resultados: Encontramos que la circunferencia de pantorrilla menor de 31 centímetros se asocia con 2,61 veces del riesgo (1.43-3.71) de tener efectos adversos en comparación a pacientes con una circunferencia de pantorrilla adecuada. Tener un IMC alterado se asocia con 1,20 veces el riesgo (1.11-1.40) de tener efectos adversos. Asimismo, la hipoalbuminemia presenta 4,33 el riesgo (2.89-6.21) de tener efectos adversos. Finalmente, el reporte de baja de peso tiene 3,65 el riesgo (2.31-4.54) de presentar efectos adversos. Conclusiones: Se encontró que existe relación entre los parámetros nutricionales y la aparición de efectos adversos en los pacientes neoplásicos. Sobre todo, se encontró una relación significativa con el parámetro de hipoalbuminemia, circunferencia de pantorrilla y el índice de masa corporal.
O TikTok não é só entretenimento: Sugestão de aplicação da rede social como recurso didático na aula de Geografia.
Authors: Groh Odair , Fernandes Mafer
Published: June 2022

Este artigo tem por objetivo demonstrar o uso da rede social TikTok como recurso didático em um plano de aula de Geografia do 1º ano do Ensino Médio, enfatizando que essa, muito utilizada por adolescentes e jovens para o entretenimento, pode ser aplicada pelos professores como uma nova linguagem e forma de abordagem de temas geográficos. A etapa de escolarização escolhida como público alvo foi o 1º ano do Ensino Médio, porque a grande maioria dos alunos são usuários da rede social acima citada, dominam as configurações e investem muitas horas do dia na visualização de vídeos curtos que, na maioria das vezes, apenas abordam temas na área do entretenimento. Sendo assim, elaboramos um plano de aula, em formato de jogo, que utiliza o TikTok em uma das etapas a fim de motivar o engajamento dos alunos no desenvolvimento de competências e habilidades geográficas pré-selecionadas. Concluímos, ao final deste artigo, que a aplicação da rede social TikTok como recurso didático possui enorme potencial a ser explorado pelos professores de Geografia.
Autonomous Pedestrian Detection model for Crowd Surveillance using Deep Learning Framework
Authors: Thakur Narina , Nagrath Preeti , Jain Rachna , Saini Dharmender , Sharma Nitika , Hemanth D. Jude
Published: June 2022

Pedestrian detection is a key ability required by most computer visions and crowd surveillance applications, with several applications such as person identification, person count and tracking. The number of techniques to identifying pedestrians in images has gradually increased in recent years, even with the significant advances in the state-of-the-art D based framework for object detection model. The research in the field of object detection and image classification has made a stride in the level of accuracy greater than 99% and the level of granularity. A powerful Object Detector, specifically designed for high-end surveillance applications, is needed that will not only position the bounding box and label it, but will also return their relative positions. The size of these bounding boxes can vary depending on the object and how it interacts with the physical world. To address these requirements, an extensive evaluation of the state-of-the-art algorithms has been presented in this paper. The work presented in this paper performs detections on MOT20 dataset using various algorithms and testing on a custom dataset recorded in our organization premises using an Unmanned Aerial Vehicle (UAV). Further, the experimental results are performed on Faster-RCNN, SSD and YOLO models. The Yolov5 model is found to outperform all other models with 61% precision and 44% of F measure value.
Filum Disease Behind Fibromyalgia: A Preliminary Study
Authors: Royo-Salvador Miguel B. , Arteaga-Armas José , Fiallos-Rivera Marco V. , Miró-Vinaixa Iolanda , Villavicencio Pamela
Published: June 2022

Background: To identify a group of patients with fibromyalgia (FM) and filum disease (FD)/neuro-cranio-vertebral syndrome (NCVS). To analyse the clinical and radiological similarities and differences between groups. To evaluate the clinical results in the FM group after sectioning of the filum terminale (SFT) with the Filum System (FS) Method. To propose an aetiopathological mechanism for FM by applying the FD/NCVS theory.Methods: A retrospective study of 394 patients diagnosed with FD/NCVS. From this sample, two subsamples were created: patients with FM (n=25) and patients without FM (n=369). The incidence of signs and symptoms were compared between groups. The FM group underwent SFT, and the evolution of signs and symptoms were assessed 8 hours, 1 month, and 1 year post-procedure.Results: 55% of the signs and symptoms assessed were present in similar proportions in both samples. There were also similar radiological findings between groups. There was a significant improvement (p<0.05) in many of the signs and symptoms in the FM group after the sectioning of the filum terminale. There were also radiological signs present in similar proportions, including descent of the cerebellar tonsils, multiple discopathy and syringomyelia.Conclusions: The overlap of signs and symptoms suggests that the underlying cause for central sensitization may be due to FD in a subgroup of FM patients. Patients with FM experience an amelioration of signs and symptoms after SFT. We propose that doctors approach FM cases with an extensive neurological exam that includes complete imaging to facilitate possible diagnosis of FD/NCVS and subsequent treatment.
Single Tube Multiplex PCR, Liquid Hybridization and ELISA (Multiplex NAT-ELISA) for rapid detection of HIV,HBV and HCV in window period
Authors: Sharma Priyanka , Batheja Gunjan , Verma Hriday Narayan , Seth Pradeep
Published: June 2022

Introduction:
A molecular assay based on single tube multiplex PCR, liquid hybridization and indirect ELISA has been designed for rapid detection of HIV-1 & 2, HCV and HBV in plasma samples (multiplex NAT-ELISA) during the window period of these infections.
Methods
Nucleic acid extracted from the virus standards and blood donor plasma samples were amplified by conventional reverse transcription-PCR with a mixture of optimized concentrations of forward and biotinylated reverse primers followed by liquid hybridization of immobilized denatured biotinylated amplicons with digoxigenin labelled specific probes and indirect ELISA to measure hybridization signals colorimetrically. Performance of Multiplex NAT-ELISA was validated by Analytical Sensitivity, Analytical Specificity, and by the “Accuracy” (Trueness) of the assay.
Results
Performance characteristics of the assay were established. Analytical sensitivity (LOD95) was 17 IU/ml (10 geq/ml) for HIV-1) 13 IU/ml (73 geq /ml) for HBV, and 15 IU/ml (66 geq/ml) for HCV. Comparison of the assay with the serological screening tests for HIV/HCV antibodies and HBsAg shows a concordance of 98%. Five serologically negative samples yielded HBV DNA in 4 samples and HCV RNA in one sample by NAT-ELISA.
Conclusions
Multiplex NAT-ELISA assay described here is performed on individual donations. The main advantage of the assay is interdiction of HIV/HCV/HBV virus infections offering a significantly higher sensitivity for detecting blood-borne infections at affordable cost (less than US$ 5 per sample). Moreover, it has analytical sensitivity that matches with that of Procleix Ultrio System and Cobas TaqScreen MPX.
Neuro-cranio-vertebral syndrome associated with Ehlers-Danlos syndrome: diagnosis and treatment
Authors: Royo-Salvador Miguel B. , Arteaga-Armas José , Fiallos-Rivera Marco , Peiró Amelia
Published: June 2022

Background
There has recently been a trend to associate Ehlers-Danlos syndrome with vertebral instability, especially cranio-cervical instability, believed to cause clinical and imaging changes that justify extensive cranio-cervical fusion. We propose a different line of argument, in which the relationship between the spinal manifestations and the clinical picture is based on distinct phenomena, mainly an abnormal caudal traction of the central nervous system and related structures.
Methods
We conducted a retrospective study from the clinical records in our institution between 2015 and 2019 and selected 10 patients with a diagnosis of Ehlers-Danlos syndrome and neuro-cranio-vertebral syndrome. We presented their images, signs and symptoms, and compared them to those seen in 373 patients with only neuro-cranio-vertebral syndrome. From the 10 patients with Ehlers-Danlos syndrome, we report the postsurgical findings of 4 patients that underwent sectioning of the filum terminale, including significant amelioration in signs and symptoms (p < 0.05).
Results
We found that patients with Ehlers-Danlos syndrome have more cranial and vertebral symptoms than patients with neuro-cranio-vertebral syndrome. There were also significant differences in the signs present in Ehlers-Danlos syndrome compared to those in neuro-cranio-vertebral syndrome. The patients that underwent sectioning of the filum terminale experienced significant improvements in signs and symptoms.
Conclusions
In patients with Ehlers-Danlos syndrome, the diagnosis of multiple cranio-vertebral or neurological manifestations must trigger a search for clinical and imaging characteristics that suggest an anomalous caudal traction, that is, a neuro-cranio-vertebral syndrome, in parallel with the tests that would help to confirm cranio-cervical instability. The probable surgical treatment would be the sectioning of the Filum terminale and cervical fusion would not at all be justified.
Microwave Speech Recognizer Empowered by a Programmable Metasurface
Authors: Ruan Hengxin , Jiang Siyuan , Zhang Hongrui , Zhao Hanting , Wang Zhuo , Hu Shengguo , Ding Jun , Cui Tie Jun , Hougne Philipp del , Li Lianlin
Published: June 2022

We present an experimental prototype of a microwave speech recognizer empowered by a programmable metasurface that can recognize voice commands and speaker identities remotely even in noisy environments and if the speaker’s mouth is hidden behind a wall or face mask. Thereby, we enable voice-commanded human machine interactions in many important but to-date inaccessible application scenarios, including smart health care and factory scenarios. The programmable metasurface is the pivotal hardware ingredient of our system because its large aperture and huge number of degrees of freedom allows our system to perform a complex sequence of tasks, orchestrated by artificial-intelligence tools. First, the speaker’s mouth is localized by imaging the scene and identifying the region of interest. Second, microwaves are efficiently focused on the speaker’s mouth to encode information about the vocalized speech in reflected microwave biosignals. The efficient focusing on the speaker’s mouth is the origin of our system’s robustness to various types of parasitic motion. Third, a dedicated neural network directly retrieves the sought-after speech information from the measured microwave biosignals. Relying solely on microwave data, our system avoids visual privacy infringements. We expect that the presented strategy will unlock new possibilities for future smart homes, ambient-assisted health monitoring and care, smart factories, as well as intelligent surveillance and security.
Research on Assessing Driving Ability of Older Driver Based on Cognitive Test: A Case Study of Beijing, China
Authors: Gong Jianguo , Guo Xiucheng , Qi Cong , Pan Lingfeng , Liu Xiaochen
Published: June 2022

Research on cognitive tests for the older drivers will contribute to accurately identify those unsafe drivers and decrease the risk of older drivers pose to themselves and other roadway users. This study aims to design and evaluate a comprehensive cognitive test including memory, reaction and judgment ability test. 72 drivers in Beijing, China in 2020 were recruited to participate in this cognitive tests to obtain detailed test information of the recorded response time and accuracy. One-way ANOVA test was proposed to examine the significance among different age and crash records groups. It can be indicated that comprehensive cognitive test was proved effective in judging the impaired older driver, where 96.7% of the safe young group and 100% of the safe older group passed the test, and 89.5% of the caution older group failed the test. The study clarified the efficiency and accuracy of each question as well as the whole test. It also confirmed the driving ability decreased with increase of age. According to the obtained comprehensive cognitive test, it provided a scientific method basis for standardizing the management of the older drivers with a license, so as to guide the older drivers to understand traffic elements and rules.