bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of a Quasi-Experimental Trial to Compare Two Models of Home Care for the Elderly in an Urban Primary Care Setting in Spain: Results of Intermediate Analysis
Authors: Burgos Díez Carolina , Sequera Requero Rosa Maria , Ferrer Costa Jose , Tarazona-Santabalbina Francisco José , Monzó Planella Marià , Cunha-Pérez Cristina , Santaeugènia González Sebastià Josep ,   Grupo ATDOM
Published: February 2022

Functional dependence is associated with an increase in need for resources, mortality, and institutionalization. Different models of home care have been developed to improve these results, but very few studies contain relevant information. This quasi-experimental study was conducted to evaluate two models of home care (HC) in a Primary Care setting: an Integrated Model (IM) (control model) and a Functional Model (FM) (study model). Material and Methods: Two years follow-up of patients 65 years old and older from two Primary Health Care Centres (58 IM, 68 FM) was carried out, recruited between June-October 2018 in Badalona (Barcelona, Spain). Results of the mid-term evaluation are presented in this article. Health status, quality of care, and resource utilization have been evaluated through comprehensive geriatric assessment, quality of life and perception of health care scales, consumption of resources and complementary tests. Results: A significant difference was detected in the number of hospital admissions (FM/IM 0.71 (1.24)/1.35 (1.90), p: 0.031) in the Accident and Emergency department (FM/IM 2.01 (2.12)/3.53 (3.59), p: 0.006) and cumulative days of admission per year (FM/IM 5.43 (10.92)/14.69 (20.90), p: 0.003). Conclusions: FM offers greater continuity of care at home for the patient and reduces hospital admissions, as well as admission time, thereby saving on costs.
A Novel Algorithm to Estimate the Significance Level of a Feature Interaction Using the Extreme Gradient Boosting Machine
Authors: Guo Chao-Yu , Chang Ke-Hao
Published: February 2022

Recent studies have revealed the importance of the interaction effect in cardiac research. An analysis would lead to an erroneous conclusion when the approach failed to tackle a significant interaction. Regression models deal with interaction by adding the product of the two interactive variables. Thus, statistical methods could evaluate the significance and contribution of the interaction term. However, machine learning strategies could not provide the p-value of specific feature interaction. Therefore, we propose a novel machine learning algorithm to assess the p-value of a feature interaction, named the extreme gradient boosting machine for feature interaction (XGB-FI). The first step incorporates the concept of statistical methodology by stratifying the original data into four subgroups according to the two interactive features. The second step builds four XGB machines with cross-validation techniques to avoid overfitting. The third step calculates a newly defined feature interaction ratio (FIR) for all possible combinations of predictors. Finally, we calculate the empirical p-value according to the FIR distribution. Computer simulation studies compared the XGB-FI with the multiple regression model with an interaction term. The results showed that the type I error of XGB-FI is valid under the nominal level of 0.05 when there is no interaction effect. The power of XGB-FI is consistently higher than the multiple regression model in all scenarios we examined. In conclusion, the new machine learning algorithm outperforms the conventional statistical model when searching for an interaction.
Has the National Fall in Smoking Rates in Ireland Been Replicated in Cancer Patients? A 5-Year Report
Authors: Fitzpatrick Patricia , Bhardwaj Nancy , Lyons Ailsa , Doherty Kirsten , Frazer Kate , McCann Amanda , Niranjan Vikram , Syed Shiraz , Fox Patricia
Published: February 2022

Smoking among cancer patients leads to poorer outcomes, yet many patients continue smoking. As part of a feasibility study of smoking cessation for cancer patients in Ireland, smoking rates were reviewed. Hospital Inpatient Enquiry (HIPE) data on the smoking status of discharges with a cancer diagnosis (overall, breast, lung, cervical and head and neck cancer) were used (2014–2018). During 2014–2017, current smoking increased for overall (10.5–11.7%) and lung cancer (24.7–27.2%), then decreased to 11.4% and 24.1%, respectively, in 2018. Current smoking increased for cervical during 2014–2018 (11–19.8%) and initially (2014–2016) for head and neck (3–12.7%) cancer, decreasing to 7.6% in 2018; breast cancer was stable at 6 ± 0.6%. These rates are lower than the Irish (23–20%) and European (29% (average)) general population. During 2014–2017, past smoking increased among overall (15.2–21%) and specific cancers, which was lower than the Irish general population (23–28%). Current smoking was highest among 50–59-year-olds (14–16%), which contrasts with the Irish general population (24–35 years at 32–28%). HIPE data are subject to potential duplicate episodes of care and under-documentation of smoking. However, trend analysis is useful, as these limitations should be stable. Rates remain high; therefore, robust documentation and smoking cessation referrals for cancer patients are important.
Deep Neural Network Approach for Pose, Illumination, and Occlusion Invariant Driver Emotion Detection
Authors: Sukhavasi Susrutha Babu , Sukhavasi Suparshya Babu , Elleithy Khaled , El-Sayed Ahmed , Elleithy Abdelrahman
Published: February 2022

Monitoring drivers’ emotions is the key aspect of designing advanced driver assistance systems (ADAS) in intelligent vehicles. To ensure safety and track the possibility of vehicles’ road accidents, emotional monitoring will play a key role in justifying the mental status of the driver while driving the vehicle. However, the pose variations, illumination conditions, and occlusions are the factors that affect the detection of driver emotions from proper monitoring. To overcome these challenges, two novel approaches using machine learning methods and deep neural networks are proposed to monitor various drivers’ expressions in different pose variations, illuminations, and occlusions. We obtained the remarkable accuracy of 93.41%, 83.68%, 98.47%, and 98.18% for CK+, FER 2013, KDEF, and KMU-FED datasets, respectively, for the first approach and improved accuracy of 96.15%, 84.58%, 99.18%, and 99.09% for CK+, FER 2013, KDEF, and KMU-FED datasets respectively in the second approach, compared to the existing state-of-the-art methods.
Assessing Patient Safety Culture in United States Hospitals
Authors: Azyabi Abdulmajeed , Karwowski Waldemar , Hancock Peter , Wan Thomas T. H. , Elshennawy Ahmad
Published: February 2022

A positive patient safety culture plays a major role in reducing medical errors and increasing productivity among healthcare staff. Furthermore, understanding staff perceptions of patient safety culture and effective patient safety factors is a first step toward enhancing quality of care and patient safety. The objectives of this study were to assess patient safety culture in hospitals in the United States and to investigate the effects of hospital and respondent characteristics on perceived patient safety culture. An analysis of 67,010 respondents in the 2018 Agency for Healthcare Research and Quality (AHRQ) comparative database was conducted with partial least squares structural equation modeling (PLS-SEM). The results revealed that perceptions of patient safety culture had a positive influence on the overall perceptions of patient safety and frequency of event reporting. Moreover, staff position, teaching status, and geographic region were found to have varying influence on the patient safety culture, overall perceptions of patient safety, and frequency of event reporting.
Prevalence of Violence Perpetrated by Healthcare Workers in Long-Term Care: A Systematic Review and Meta-Analysis
Authors: Conti Alessio , Scacchi Alessandro , Clari Marco , Scattaglia Marco , Dimonte Valerio , Gianino Maria Michela
Published: February 2022

This systematic review and meta-analysis aimed to determine the prevalence of violence perpetrated by healthcare workers (HCWs) against patients in long-term care (LTC). For this purpose, five relevant databases were searched. Two reviewers extracted data from the included articles independently and assessed their quality. Overall and subgroup random-effects pooled prevalence meta-analyses were performed. A series of meta-analyses stratified by study quality were also performed due to high heterogeneity. Nineteen articles were included, physical restraint (22%; CI: 15–29), verbal abuse (22%; CI: 16–28), and neglect (20%; CI: 15–26) attained the highest overall prevalence, while sexual abuse was less reported (2%; CI: 1–3). The prevalence of witnessed violence is generally higher than those reported by HCWs, and patients and their relatives reported fewer cases of violence than HCWs. Differences in violence perpetrated among LTC settings were found. Neglect (64%; CI: 56–72) and financial abuse (7%; CI: 3–12) reported by HCWs were higher in home care, while verbal abuse (21%; CI: 7–39) reported by patients or their families was higher in nursing homes. Our findings highlight that violence perpetrated by HCWs toward patients represents a significant concern in LTC, suggesting the adoption of reliable monitoring approaches and provision of assistance to victims in reporting abuse.
Measuring User-Perceived Characteristics for Banking Services: Proposing a Methodology
Authors: Bitkina Olga Vl. , Park Jaehyun , Kim Hyun K.
Published: February 2022

With the continuous technological enhancement of banking services, customers can avail of better, more secure services which present improved opportunities and convenience. Of the many methods available to perform banking operations, customers commonly use traditional banking, online banking, and mobile banking. Each of these existing methods has advantages and limitations that affect customer experience, trust, satisfaction, and continued intention to use such services. In this study, an attempt was made to develop and fit a model to evaluate and measure the effect of perceived characteristics on banking services. To this end, a questionnaire was administered to 91 participants in Korea to investigate their experiences in the three types of services: offline banking (traditional banking), online banking, and automated teller machines (ATM). The factor design for evaluating the user experience through the perceived characteristics of the banking system was performed by conducting exploratory and confirmatory factor analyses. The proposed model exhibited validity and reliability to evaluate the user experience in the banking system. The results obtained can help banking specialists and professionals increase the level of customers’ trust, loyalty, and intention to use their services.
Factors Associated with Quality of Life in Patients with Type 2 Diabetes of South Benin: A Cross-Sectional Study
Authors: Alaofè Halimatou , Amoussa Hounkpatin Waliou , Djrolo Francois , Ehiri John , Rosales Cecilia
Published: February 2022

Background: Type 2 diabetes (T2D) adversely affects health-related quality of life (QoL). However, little is known about the QoL of diabetic patients in Benin, where the disease is a growing concern. Thus, this study aims to assess the QoL and its associated factors among T2D patients in Cotonou, southern Benin. Methods: A total of 300 T2D patients (age > 18 years) were enrolled, and the diabetes-specific quality of life (DQoL) and Natividad self-care behaviors’ (SCB) instruments were used for data collection. DQoL scores were calculated, and factors associated with DQoL explored using logistic regression. Results: The mean of patients’ DQoL was 38.1 ± 4.1, with 43% having low QoL. In terms of DQoL, 56.3% reported a high diabetes impact, followed by low life satisfaction (53%) and high worry about diabetes (32.7%). In the logistic regression analysis, education, marital status, occupation, family history of diabetes, complications, and social support were associated with DQoL. SCB factors, including healthy eating, problem-solving, coping strategies, and risk reduction, were significant predictors of DQoL. Conclusions: Patients’ empowerment, starting with self-management education, is essential to improve the QoL of T2D patients in Cotonou. However, the programs need to target low education, low socioeconomic status, low social support, and overweight patients.
Effectiveness of a Parent Training Programme for Parents of Adolescents with Autism Spectrum Disorders: Aiming to Improve Daily Living Skills
Authors: Matsumura Nanako , Fujino Haruo , Yamamoto Tomoka , Tanida Yuki , Ishii Atsuko , Tatsumi Aika , Nakanishi Mariko , Tachibana Masaya , Mohri Ikuko , Okuno Hiroko
Published: February 2022

Parent training (PT) has been well established in younger children with autism spectrum disorder (ASD) but is less well studied in adolescents. This study examined the effects of attempting PT to enhance the daily living skills (DLSs) of adolescents with ASD. Twenty-five parents of adolescents with ASD participated in either the immediate- or delayed-treatment control condition. Children’s DLSs were evaluated using the DLS domain of the Vineland Adaptive Behaviour Scales-II, and the achievement of the DLSs practised by the children at home was the subject of the evaluation. The DLS domain score showed no improvement in the treatment group compared to the control group. However, some parents in the treatment group reported that their children acquired the target DLSs and more sophisticated communication behaviours. In addition, one measure suggested that parents increased their praising behaviours. These changes may have been driven by the completion of the parent training. We discuss several aspects of developing parent-mediated interventions based on the current intervention situation and observed changes.
Perceived COVID-19 Threat and Reactions to Noncompliant Health-Protective Behaviors: The Mediating Role of Desired Cultural Tightness and the Moderating Role of Age
Authors: Baldner Conrad , Di Santo Daniela , Viola Marta , Pierro Antonio
Published: February 2022

The COVID-19 pandemic is a health crisis that requires individuals to comply with many health-protective behaviors. Following the previous literature, cultural tightness has been found to be a key mechanism to increase coordination in order to mitigate collective threats (e.g., COVID-19). In this study, we test a moderated mediation model to examine whether the perceived COVID-19 threat could intensify the extent of desired tightness (i.e., a personal desire for cultural tightness), moderated by age. Subsequently, we test whether this could intensify individuals’ emotional reactions to non-compliance with COVID-19 health protective behaviors. The study relies on a cross-sectional design, with a sample of 624 participants residing in central Italy (i.e., Lazio). The data were collected from February to October 2021. Questionnaires contained self-reporting measures of the perceived COVID-19 threat, desired tightness, and personal emotional reactions to non-compliance with COVID-19 preventive measures (e.g., wearing a mask). The results confirm that the perceived COVID-19 threat is associated with an increase in the desire for cultural tightness—and that this relationship was moderated by age—and, consequently, with intolerance for noncompliance with preventive behaviors. Additionally, both direct and indirect effects of the perceived COVID-19 threat on negative emotional reactions to noncompliance were significant; this indirect effect was larger at high (+1 SD) age than at low (−1 SD) age. Overall, this research provides some insight into how people can respond to the current pandemic threat, and how this may have implications for violating rules and regulations to keep contagion under control.
Feasibility of an Ultrasound-Based Method for Measuring Talar Displacement during the Anterior Drawer Stress Test Using a Telos Device: A Preliminary Study
Authors: Tsutsumi Kaori , Nakaya Utayo , Koshino Yuta , Tateno Mari , Matsumoto Kazuhisa , Tanaka Mai , Yokoyama Mika , Horie Tatsunori , Samukawa Mina , Kamishima Tamotsu , Tohyama Harukazu
Published: February 2022

This study was conducted to measured talar displacement using ultrasound during an anterior drawer test (ADT) with a Telos device. Five adults (3 men and 2 women; 8 ankles; mean age: 23.2 y) with a history of ankle sprain and eight adults (5 men and 3 women; 16 ankles; mean age: 22.1 y) without a history of ankle sprain were recruited into a history of ankle sprain (HAS) and a control group, respectively. Talar displacement was observed in response to load forces applied by a Telos device during the ultrasound stress imaging test. The ultrasound probe was placed 5 mm inside from the center of the Achilles tendon on the posterior ankle along the direction of the major axis. The inter-rater reliability for the present method was classified as good and excellent (ICC(2,2) = 0.858 and 0.957 at 120 N and 150 N, respectively) in the control group and excellent (ICC(2,2) = 0.940 and 0.905 at 120 N and 150 N, respectively) in the HAS group, according to specific intraclass correlation coefficient values. We found that talar displacement during the ADT was lower in the HAS group than in the control group. Analysis of the receiver operating characteristic curve revealed that the quantitative ultrasound-based ADT using a Telos device was superior to the X-ray-based test in detecting reduced ankle joint mobility during the ADT (area under the curve of 0.905 and 0.726 at a force of 150 N using ultrasound-based and X-ray-based tests, respectively). Further investigation is needed; nevertheless, this preliminary study suggests that the ultrasound-based quantitative ADT using a Telos device might detect talar displacement more sensitively than the conventional stress X-ray.
High in Utero Exposure to Perfluoroalkyl Substances from Drinking Water and Birth Weight: A Cohort Study among Infants in Ronneby, Sweden
Authors: Engström Karin , Axmon Anna , Nielsen Christel , Rignell-Hydbom Anna
Published: February 2022

In 2013, the drinking water for one-third of the households in Ronneby, Sweden, was found to be contaminated by perfluorinated alkyl substances (PFAS, >10,000 ng/L) from Aqueous Film Forming Foam (AFFF). In utero PFAS exposure can influence birth weight, but little is known about the effects at very high levels. This study aimed to examine the association between in utero PFAS exposure and birth weight. Infants with mothers from Ronneby exposed to contaminated water at home (high exposure) and infants with mothers from Ronneby not exposed to contaminated water at home (low exposure) were compared to infants with mothers from Blekinge county excluding Ronneby (referents). All infants born in Blekinge county 1995–2013 were included (n = 30,360). Differences in birth weight were only seen among infants born after 2005. For boys, Ronneby high exposure had a lower mean birth weight than referents (−54 g, 95% CI −97; −11). For girls, Ronneby high exposure had a higher mean birth weight than referents (47 g, 95% CI 4; 90). There were no differences in birth weight between referents and Ronneby low exposure. In conclusion, high exposure to PFAS may influence birth weight in a sex-specific way, although the effect estimates were relatively small.
Financing Constraints, Carbon Emissions and High-Quality Urban Development—Empirical Evidence from 290 Cities in China
Authors: Wang Shaobo , Liu Junfeng , Qin Xionghe
Published: February 2022

The tightening of the financing environment and global climate change have become urgent problems for high-quality economic development all over the world. Facing these challenges, the Chinese government is committed to alleviating regional financing constraints and setting carbon-emission reduction targets. However, are these measures effective for high-quality urban development? This paper attempts to use unbalanced panel data from 290 cities on the Chinese mainland from 2004–2017 to provide an answer to the problem using a scatter plot and the mediator effect model. Results show that: (1) financing constraints limit the funds required for urban development, which is not conducive to high-quality urban development, but high-quality urban development has the characteristics of “path dependence”; (2) In the context of environmental regulation, financing constraints are mainly enacted through reducing carbon emissions, which is inconducive to high-quality urban development. Carbon emissions are the transmission mechanism whereby financing constraints affect high-quality urban development; (3) Cities with large financing constraints have insufficient capital investment for high-quality urban development, and the aggravation of financing constraints has an increasingly obvious inhibitory effect on high-quality urban development. Moreover, due to the effect of the global economic crisis in 2008, the negative effect of financing constraints on high-quality urban development had the characteristics of U-shaped fluctuation. Thus, this paper believes that the implementation of China’s double carbon policy is at the expense of high-quality urban development, and there is a long way to go before high-quality urban development reaches later stages. Other countries should carefully weigh up the relationship between environmental pollution and economic development when facing financing constraints.
The Role of Virtual Reality as a Psychological Intervention for Mental Health Disturbances during the COVID-19 Pandemic: A Narrative Review
Authors: Hatta Muhammad Hizri , Sidi Hatta , Sharip Shalisah , Das Srijit , Saini Suriati Mohamed
Published: February 2022

The COVID-19 pandemic spread throughout the world and created many problems. The COVID-19 pandemic caused an increase in mortality and morbidity, including mental health problems. Around the world, the movement control order (MCO) was strictly enforced, but the spread of the infection epidemic was still rampant. The magnitude of the increase in mental health illnesses has caused many individuals to suffer. Given that face-to-face interventions are challenging to carry out during an outbreak, we need to address this critical problem through an online approach, such as virtual reality (VR). This approach is vital to helping patients deal with their existing problems in more pragmatic, practical, and customer-friendly ways. Thus, in the present review, we proposed the development of a virtual digital device for this noble purpose. Various challenges, improvements, and expectations for VR applications were outlined and discussed in this narrative review.
Classical and Next-Generation Vaccine Platforms to SARS-CoV-2: Biotechnological Strategies and Genomic Variants
Authors: Simões Rachel Siqueira de Queiroz , Rodríguez-Lázaro David
Published: February 2022

Several coronaviruses (CoVs) have been identified as human pathogens, including the α-CoVs strains HCoV-229E and HCoV-NL63 and the β-CoVs strains HCoV-HKU1 and HCoV-OC43. SARS-CoV, MERS-CoV, and SARS-CoV-2 are also classified as β-coronavirus. New SARS-CoV-2 spike genomic variants are responsible for human-to-human and interspecies transmissibility, consequences of adaptations of strains from animals to humans. The receptor-binding domain (RBD) of SARS-CoV-2 binds to receptor ACE2 in humans and animal species with high affinity, suggesting there have been adaptive genomic variants. New genomic variants including the incorporation, replacement, or deletion of the amino acids at a variety of positions in the S protein have been documented and are associated with the emergence of new strains adapted to different hosts. Interactions between mutated residues and RBD have been demonstrated by structural modelling of variants including D614G, B.1.1.7, B1.351, P.1, P2; other genomic variants allow escape from antibodies generated by vaccines. Epidemiological and molecular tools are being used for real-time tracking of pathogen evolution and particularly new SARS-CoV-2 variants. COVID-19 vaccines obtained from classical and next-generation vaccine production platforms have entered clinicals trials. Biotechnology strategies of the first generation (attenuated and inactivated virus–CoronaVac, CoVaxin; BBIBP-CorV), second generation (replicating-incompetent vector vaccines–ChAdOx-1; Ad5-nCoV; Sputnik V; JNJ-78436735 vaccine-replicating-competent vector, protein subunits, virus-like particles–NVX-CoV2373 vaccine), and third generation (nucleic-acid vaccines–INO-4800 (DNA); mRNA-1273 and BNT 162b (RNA vaccines) have been used. Additionally, dendritic cells (LV-SMENP-DC) and artificial antigen-presenting (aAPC) cells modified with lentiviral vector have also been developed to inhibit viral activity. Recombinant vaccines against COVID-19 are continuously being applied, and new clinical trials have been tested by interchangeability studies of viral vaccines developed by classical and next-generation platforms.
Procedure for Determining Dimensional Allowances for PPE Using 3D Scanning Methods
Authors: Szkudlarek Joanna , Owczarek Grzegorz , Jachowicz Marcin , Zagrodny Bartłomiej
Published: February 2022

The article describes the importance of dimensional allowances, which are a consequence of the use of personal protective equipment (PPE) for work safety. The method of 3D scanning was proposed for determining the dimensional allowances which has been preliminary validated. Two geometric solids (a cylinder and a cuboid) were used to approximate the minimum space around the person using PPE. The solids are a simplified representation of the silhouette of a human subject performing activities in a confined work environment. They also correspond to the typical shapes of access openings and confined spaces, reflecting the real working conditions of welders, firefighters, mine rescuers, and other rescue teams. A detailed analysis of dimensional allowances for a full welding PPE set is provided. Based on the adopted parameters: the dimensions of the body, the base area and the volume, the differences in the dimensions of the body of a person dressed in underwear and in PPE were compared. The results of the presented studies indicate a significant role of dimensional allowances in interactions between persons wearing PPE and the work environment. The results are planned to be implemented in a new anthropometric atlas of human’s measures used for ergonomic design.
Remote, Hybrid, and On-Site Work during the SARS-CoV-2 Pandemic and the Consequences for Stress and Work Engagement
Authors: Wontorczyk Antoni , Rożnowski Bohdan
Published: February 2022

With the COVID-19 pandemic having disrupted economies, businesses, and individual activities, it is important to examine how different forms of work affect employee behaviour. This study applies work engagement (the key construct in organisational psychology) as the dependent variable and considers its determinants in the form of stress factors and attitudes toward remote work. A cross-sectional study was conducted. A total of 544 (Female = 58.5%) workers were surveyed: remote (n = 144), hybrid (n = 142), and on-site (n = 258). The selection for the study was purposive. Standardised survey questionnaires were used in the study: UWES-9, Stress Management Standards, and Attitudes toward Remote Work. The obtained results indicate that there were no significant differences between groups in terms of the intensity of work engagement, but work engagement was explained by other variables that are different in each of the studied groups. Relationships and use of social media were the most important factors among remote workers. For on-site workers, the most important factors were control and role definition. For practitioners, the results indicate which aspects of work should be considered in order to maintain high levels of work engagement when employees are transferring to other forms of work.
Risk Factors for Excessive Social Media Use Differ from Those of Gambling and Gaming in Finnish Youth
Authors: Castrén Sari , Mustonen Terhi , Hylkilä Krista , Männikkö Niko , Kääriäinen Maria , Raitasalo Kirsimarja
Published: February 2022

Purpose: Adolescents’ excessive social media use has characteristics similar to other addictive behaviours. This study aims to explore whether the same risk factors are associated with excessive social media use as with excessive gaming and gambling among Finnish adolescents. Methods: Multinomial logistic regression analyses were carried out using the European School Survey Project on Alcohol and Other Drugs data, collected from Finnish adolescents aged 15–16 in 2019 (n = 4595). Results: Excessive use of social media was more common among girls (reported by 46% of respondents) than boys of the same age (28%), whereas boys reported both excessive gaming (23%) and gambling (6%) more often than girls (4% and 1%, respectively). All differences between genders were statistically significant (p < 0.0001). Daily smoking was associated with a high risk of excessive gambling (AOR = 3.23) and low risk of excessive gaming (AOR = 0.27) but had no significant effect on excessive social media use. Cannabis use in the past 12 months was positively associated only with excessive gambling (AOR = 2.39), while past 12 months alcohol consumption increased the risk for excessive social media use (AOR = 1.25). Conclusions: Adolescent girls are at greater risk of excessive social media use than boys, while boys are at greater risk of excessive gaming and gambling. The associations with known risk factors are somewhat different for excessive use of social media as compared to excessive gambling and gaming and should be acknowledged when developing preventive measures for adolescents.
Mentalizing Emotions and Social Cognition in Bullies and Victims
Authors: Pedditzi Maria Luisa , Fadda Roberta , Striano Skoler Tricia , Lucarelli Loredana
Published: February 2022

Mentalizing is the ability to represent mental states to navigate the social world. A reduced mentalizing ability is a risk factor for a variety of psychological issues. Several studies indicated deficits in social cognition in bullies and victims, specifically in mentalizing anger. However, only a few studies investigated mentalizing abilities related to both anger and happiness in pre-adolescence. Our study investigated possible differences in the ability to mentalize anger and happiness in preadolescent bullies and victims, compared to a control group. We interviewed 104 preadolescents (44% males; 56% females; M = 13.2 years; SD = 0.82) and administered the Olweus Questionnaire to identify bullies and victims. We applied a narrative approach to investigate the mental state language referred to anger and happiness. The results indicated a reduced ability to mentalize anger in bullies and victims compared to controls. Both bullies and victims tended to consider anger and happiness predominantly as behavioral conditions rather than a state of mind. These results highlight the need to promote effective intervention programs to prevent bullying by enhancing appropriate mentalization of emotions in pre-adolescents.
Digital Economy Development, Industrial Structure Upgrading and Green Total Factor Productivity: Empirical Evidence from China’s Cities
Authors: Liu Yang , Yang Yanlin , Li Huihui , Zhong Kaiyang
Published: February 2022

The digital economy is an important engine to promote sustainable economic growth. Exploring the mechanism by which the digital economy promotes economic development, industrial upgrading and environmental improvement is an issue worth studying. This paper takes China as an example for study and uses the data of 286 cities from 2011 to 2019. In the empirical analysis, the direction distance function (DDF) and the Global Malmquist-Luenberger (GML) productivity index methods are used to measure the green total factor productivity (GTFP), while Tobit, quantile regression, impulse response function and intermediary effect models are used to study the relationship among digital economy development, industrial structure upgrading and GTFP. The results show that: (1) The digital economy can significantly improve China’s GTFP; however, there are clear regional differences. (2) The higher the GTFP, the greater the promotion effect of the digital economy on the city’s GTFP. (3) From a dynamic long-term perspective, the digital economy has indeed positively promoted China’s GTFP. (4) The upgrading of industrial structures is an intermediary transmission mechanism for the digital economy to promote GTFP. This paper provides a good reference for driving green economic growth and promoting the environment.
Toxic Psychosocial Stress, Resiliency Resources and Time to Dementia Diagnosis in a Nationally Representative Sample of Older Americans in the Health and Retirement Study from 2006–2016
Authors: Nkwata Allan K. , Zhang Ming , Song Xiao , Giordani Bruno , Ezeamama Amara E.
Published: February 2022

Background: Toxic stress (TS), resiliency-promoting factors (RPFs) and their interactions were investigated in relationship to incident dementia in a nationally representative sample (n = 6516) of American adults ≥50 years enrolled in the Health and Retirement Study between 2006 and 2016. Methods: TS included experiences of everyday discrimination and RPF included personal mastery. Race/ethnicity was self-reported as African American, Caucasian, or Other. Multivariable Cox proportional hazards regression models estimated TS-, RPF- and race-associated hazard ratios (HR) for dementia diagnosis and 95% confidence intervals (CIs) with adjustment for comorbidity, lifestyle, and socio-demographic confounders. Results: Discrimination-associated risk of dementia diagnosis on average increased with education level [discrimination x education, p = 0.032; HR = 1.75 (95% CI: 1.01–3.03) if < high school, HR = 5.67 (95% CI: 2.94–10.94) if high school completed and HR = 2.48 (95% CI: 1.53–4.00) if ≥some college education]. Likewise, African American vs. Caucasian race disparity in new-onset dementia was evident (HR = 2.12, 95% CI: 1.42–3.17) among adults with high-mastery while absent (HR = 1.35, 95% CI: 0.75–2.41) among adults with low mastery (Mastery x Race, p = 0.01). Conclusions: TS is a contextual driver of incident dementia that seemingly operates in a race and RPF-dependent fashion among American adults. Association pattern suggests that TS may overwhelm the cognitive reserve benefit of RPF particularly in status-inconsistent contexts including persons subjected to discrimination despite high education and persons of African American descent despite high mastery. Policies that reduce discrimination and promote equitable treatment by race/ethnicity may support cognitive resiliency and reduce the risk of dementia diagnosis in adult Americans.
Cumulative Incidence of SARS-CoV-2 in Healthcare Workers at a General Hospital in Germany during the Pandemic—A Longitudinal Analysis
Authors: Platten Martin , Nienhaus Albert , Peters Claudia , Cranen Rita , Wisplinghoff Hilmar , Kersten Jan Felix , Bach Alexander Daniel , Michels Guido
Published: February 2022

Health workers (HW) are at increased risk for SARS-CoV-2 infection. In order to monitor the infection dynamic on the basis of contact with patients, HW at the St. Antonius Hospital (SAH) were tested four times in one year by PCR and serology. The cumulative incidence of infection in HW was calculated. Swab and blood tests were simultaneously performed between April 2020 and April 2021. Risk factors and demographic information were assessed at the beginning of the study. The response rate was above 75% in all rounds of testing. The study comprised 1506 HW, 165 (10.6%) of which tested positive for SARS-CoV-2 infection. Working in an ICU or on wards with patient contact were risk factors (OR 4.4, 95% CI 1.73–13.6 and OR 2.9, 95% CI 1.27–8.49). At the end of the study, the majority of HW (810 of 1363 (59.4%)) had been vaccinated at least once. A total of 29.1% of unvaccinated HW and 5.3% of vaccinated HW showed an immune response typical for natural SARS-CoV-2 infection. Of the 73 HW who provided information on the course of the disease, 31.5% reported that their quality of life continued to be impaired. The cumulative incidence of infection was low in these HW, which may be attributed to vaccination and good hygiene. Nevertheless, a work-related infection risk was identified, highlighting the need to improve protection against infection. A high risk of developing long COVID was found after the infection has subsided. Special rehabilitation programs should be provided and HW should be compensated for reduced work capacity in the case that rehabilitation fails or takes a long time.
Different Coping Patterns among US Graduate and Undergraduate Students during COVID-19 Pandemic: A Machine Learning Approach
Authors: Zhao Yijun , Ding Yi , Shen Yangqian , Failing Samuel , Hwang Jacqueline
Published: February 2022

COVID-19 caused unprecedented disruptions to regular university operations worldwide. Dealing with 100% virtual classrooms and suspension of essential in-person activities resulted in significant stress and anxiety for students coping with isolation, fear, and uncertainties in their academic careers. In this study, we applied a machine learning approach to identify distinct coping patterns between graduate and undergraduate students when facing these challenges. We based our study on a large proprietary dataset collected from 517 students in US professional institutions during an early peak of the pandemic. In particular, we cast our problem under the association rule mining (ARM) framework by introducing a new method to transform survey data into market basket items and customer transactions in which students’ behavioral patterns were analogous to customer purchase patterns. Our experimental results suggested that graduate and undergraduate students adopted different ways of coping that could be attributed to their different maturity levels and lifestyles. Our findings can further serve as a focus of attention (FOA) tool to facilitate customized advising or counseling to address the unique challenges associated with each group that may warrant differentiated interventions.
Assessing Ecological Infrastructure Investments—A Case Study of Water Rights Trading in Lu’an City, Anhui Province, China
Authors: Wang Qiuyan , Zhao Qingjian
Published: February 2022

Investment in ecological infrastructure construction alters behaviors and quantities of the ecosystem service (ES) provided, and market-clearing can learn the value and scale of ES. We integrated ecological and economic methods to put forward the idea of realizing the aquatic ecological products’ value by investing in water-saving irrigation infrastructure. Firstly, the demand for aquatic ecological products was calculated by a Cobb–Douglas production function, and then the supply of aquatic ecological products was estimated by InVEST and water-saving potential models; Finally, the scale of ecological infrastructure investment and the aquatic ecological products’ value are illustrated by cost-benefit analysis and market equilibrium theory. Research indicates that, (1) industrial water efficiency is high, and the ecological infrastructure construction provides a considerable number of ecological products; (2) implementing water-saving irrigation project is at least 30% more profitable than maintaining the status quo; (3) the market-clearing results showed that the market equilibrium price is about 0.256 USD/m3, and the transaction volume is about 1.667 billion m3. The output value of industrial enterprises after buying water can reach about 1.37 times of the current stage, reflecting the aquatic ecological products’ value. Investment in water-saving irrigation infrastructure has huge economic, social and ecological benefits, and provides reference for decision-making.
A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase
Authors: Kakhkharova Zarina I. , Zharkov Dmitry O. , Grin Inga R.
Published: February 2022

Human NEIL2 DNA glycosylase (hNEIL2) is a base excision repair protein that removes oxidative lesions from DNA. A distinctive feature of hNEIL2 is its preference for the lesions in bubbles and other non-canonical DNA structures. Although a number of associations of polymorphisms in the hNEIL2 gene were reported, there is little data on the functionality of the encoded protein variants, as follows: only hNEIL2 R103Q was described as unaffected, and R257L, as less proficient in supporting the repair in a reconstituted system. Here, we report the biochemical characterization of two hNEIL2 variants found as polymorphisms in the general population, R103W and P304T. Arg103 is located in a long disordered segment within the N-terminal domain of hNEIL2, while Pro304 occupies a position in the β-turn of the DNA-binding zinc finger motif. Similar to the wild-type protein, both of the variants could catalyze base excision and nick DNA by β-elimination but demonstrated a lower affinity for DNA. Steady-state kinetics indicates that the P304T variant has its catalytic efficiency (in terms of kcat/KM) reduced ~5-fold compared with the wild-type hNEIL2, whereas the R103W enzyme is much less affected. The P304T variant was also less proficient than the wild-type, or R103W hNEIL2, in the removal of damaged bases from single-stranded and bubble-containing DNA. Overall, hNEIL2 P304T could be worthy of a detailed epidemiological analysis as a possible cancer risk modifier.
Novel Role of Ghrelin Receptor in Gut Dysbiosis and Experimental Colitis in Aging
Authors: Noh Ji Yeon , Wu Chia-Shan , DeLuca Jennifer A. A. , Devaraj Sridevi , Jayaraman Arul , Alaniz Robert C. , Tan Xiao-Di , Allred Clinton D. , Sun Yuxiang
Published: February 2022

Chronic low-grade inflammation is a hallmark of aging, which is now coined as inflamm-aging. Inflamm-aging contributes to many age-associated diseases such as obesity, type 2 diabetes, cardiovascular disease, and inflammatory bowel disease (IBD). We have shown that gut hormone ghrelin, via its receptor growth hormone secretagogue receptor (GHS-R), regulates energy metabolism and inflammation in aging. Emerging evidence suggests that gut microbiome has a critical role in intestinal immunity of the host. To determine whether microbiome is an integral driving force of GHS-R mediated immune-metabolic homeostasis in aging, we assessed the gut microbiome profiles of young and old GHS-R global knockout (KO) mice. While young GHS-R KO mice showed marginal changes in Bacteroidetes and Firmicutes, aged GHS-R KO mice exhibited reduced Bacteroidetes and increased Firmicutes, featuring a disease-susceptible microbiome profile. To further study the role of GHS-R in intestinal inflammation in aging, we induced acute colitis in young and aged GHS-R KO mice using dextran sulfate sodium (DSS). The GHS-R KO mice showed more severe disease activity scores, higher proinflammatory cytokine expression, and decreased expression of tight junction markers. These results suggest that GHS-R plays an important role in microbiome homeostasis and gut inflammation during aging; GHS-R suppression exacerbates intestinal inflammation in aging and increases vulnerability to colitis. Collectively, our finding reveals for the first time that GHS-R is an important regulator of intestinal health in aging; targeting GHS-R may present a novel therapeutic strategy for prevention/treatment of aging leaky gut and inflammatory bowel disease.
Global Identification and Characterization of C2 Domain-Containing Proteins Associated with Abiotic Stress Response in Rice (Oryza sativa L.)
Authors: Zhang Hongjia , Zeng Yuting , Seo Jeonghwan , Kim Yu-Jin , Kim Sun Tae , Kwon Soon-Wook
Published: February 2022

C2 domain-containing proteins (C2DPs) have been identified in different genomes that contain single or multiple C2 domains in their C- or N-terminal. It possesses higher functional activity in the transmembrane regions. The identification of C2 domains were reported in a previous study, such as multiple C2 domains and transmembrane-region proteins (MCTPs) and N-terminal-TM-C2 domain proteins (NTMC2s) of rice, Arabidopsis thaliana, and cotton, whereas the C2DP gene family in rice has not been comprehensively studied, and the role of the C2DP gene in rice in response to abiotic stress is not yet fully understood. In this study, we identified 82 C2DPs in the rice genome and divided them into seven groups through phylogenetic analysis. The synteny analysis revealed that duplication events were either exhibited within the genome of rice or between the genomes of rice and other species. Through the analysis of cis-acting elements in promoters, expression profiles, and qRT-PCR results, the functions of OsC2DPs were found to be widely distributed in diverse tissues and were extensively involved in phytohormones-related and abiotic stresses response in rice. The prediction of the microRNA (miRNA) targets of OsC2DPs revealed the possibility of regulation by consistent miRNAs. Notably, OsC2DP50/51/52 as a co-tandem duplication exhibited similar expression variations and involved the coincident miRNA-regulation pathway. Moreover, the results of the genotypic variation and haplotype analysis revealed that OsC2DP17, OsC2DP29, and OsC2DP49 were associated with cold stress responses. These findings provided comprehensive insights for characterizations of OsC2DPs in rice as well as for their roles for abiotic stress.
Increased L-Selectin on Monocytes Is Linked to the Autoantibody Profile in Systemic Sclerosis
Authors: Brezovec Neža , Perdan-Pirkmajer Katja , Kuret Tadeja , Burja Blaž , Sodin-Šemrl Snežna , Čučnik Saša , Lakota Katja
Published: February 2022

Monocytes are known to be implicated in the pathogenesis of systemic sclerosis (SSc), as they exert prominent migratory, adhesive, and chemotactic properties. The aim of our study was to characterize the surface expression of adhesion/chemotactic molecules (CD62L, CD11b, CCR2, CCR5) on the SSc monocytes and determine correlations with the clinical presentation of SSc. We included 38 SSc patients and 36 healthy age-and sex-matched controls. Isolated monocytes, as well as in vitro serum-treated monocytes, were analyzed by flow cytometry; additionally, soluble CD62L was measured in serum. We found increased soluble CD62L in the SSc serum samples and increased CD62L on the surface of the SSc monocytes in the in the same set of patients. Among samples with determined SSc-specific autoantibodies, the surface CD62L was the lowest in patients positive for anti-PM/Scl autoantibodies and the highest in patients with anti-topoisomerase I autoantibodies (ATA). The treatment of isolated healthy monocytes with ATA-positive SSc serum resulted in increased surface CD62L expression. Moreover, surface CCR5 was reduced on the monocytes from SSc patients with interstitial lung disease but also, along with CCR2, negatively correlated with the use of analgesics/anti-inflammatory drugs and immunosuppressants. In conclusion, increased CD62L on SSc monocytes, particularly in ATA-positive patients, provides new insights into the pathogenesis of SSc and suggests CD62L as a potential therapeutic target.