bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Reactions of o‐Quinone Methides with Pyridinium Methylides: A Diastereoselective Synthesis of 1,2‐Dihydronaphtho[2,1‐b]furans and 2,3‐Dihydrobenzofurans.
Authors: Osyanin Vitaly A. , Osipov Dmitry V. , Klimochkin Yuri N.
Published: October 2013

This new method proceeds with complete diastereoselectivity giving the title compounds as trans‐isomers exclusively.
ChemInform Abstract: Rhodium‐Catalyzed Asymmetric Arylative Cyclization of meso‐1,6‐Dienynes Leading to Enantioenriched cis‐Hydrobenzofurans.
Authors: He Zhi‐Tao , Tian Bing , Fukui Yuki , Tong Xiaofeng , Tian Ping , Lin Guo‐Qiang
Published: October 2013

A tandem arylrhodation/conjugate addition reaction/rhodium‐catalyzed asymmetric arylative cyclization of cyclohexadienone‐containing meso‐1,6‐dienynes is developed to provide optically pure cis‐hydroxybenzofurans in good yields.
ChemInform Abstract: Highly Enantioselective Construction of 3‐Hydroxy Oxindoles Through a Decarboxylative Aldol Addition of Trifluoromethyl α‐Fluorinated gem‐Diols to N‐Benzyl Isatins.
Authors: Saidalimu Ibrayim , Fang Xiang , He Xiao‐Peng , Liang Jing , Yang Xueyan , Wu Fanhong
Published: October 2013

An organocatalytic asymmetric direct aldol addition reaction of gem‐diols to isatins is developed.
ChemInform Abstract: Chelation‐Assisted Rh(III)‐Catalyzed C2‐Selective Oxidative C—H/C—H Cross‐Coupling of Indoles/Pyrroles with Heteroarenes.
Authors: Qin Xurong , Liu Hu , Qin Dekun , Wu Qian , You Jingsong , Zhao Dongbing , Guo Qiang , Huang Xiaolei , Lan Jingbo
Published: October 2013

This is the first example of a catalytic system promoting an oxidative C—H/C—H heterocoupling not only between electron‐rich heteroarenes but also between electron‐deficient and electron‐rich ones.
ChemInform Abstract: Catalytic Asymmetric Synthesis of Pyrroloindolines via a Rhodium(II)‐Catalyzed Annulation of Indoles.
Authors: Spangler Jillian E. , Davies Huw M. L.
Published: October 2013

Various title compounds are prepared with high levels of enantioinduction via a formal [3 + 2] cycloaddition of C(3)‐substituted indoles and 4‐aryl‐1‐sulfonyl‐1,2,3‐triazoles as carbenoid precursors.
ChemInform Abstract: Ammonium Chloride‐Catalyzed Synthesis of Benzo‐Fused Heterocycles from o‐Substituted Anilines and Orthoesters.
Authors: Fortenberry Chelsea , Nammalwar Baskar , Bunce Richard A.
Published: October 2013

An inexpensive and efficient method to synthesize benzimidazole (III), benzoxazole (V) and benzothiazole (VII) derivatives under mild conditions is described.
ChemInform Abstract: One‐Pot Synthesis of 3‐Hydroxyquinolin‐2(1H)‐ones from N‐Phenylacetoacetamide via PhI(OCOCF3)2‐Mediated α‐Hydroxylation and H2SO4‐Promoted Intramolecular Cyclization.
Authors: Yuan Yucheng , Yang Rui , Zhang‐Negrerie Daisy , Wang Junwei , Du Yunfei , Zhao Kang
Published: October 2013

This new strategy affords different substituted quinolinone derivatives and gives access to viridicatin (IIa) and its derivatives, which inhibit the replication of the HI‐virus.
ChemInform Abstract: Synthesis of Alkyl N‐(4‐Nitrophenyl)‐3/2‐oxomorpholine‐2/3‐carboxylates by Rhodium(II) Acetate Catalyzed O—H and N—H Carbene Insertion.
Authors: Trstenjak Uros , Ilas Janez , Kikelj Danijel
Published: October 2013

Two strategies are developed: intramolecular N—H carbene insertion of substrate (I) provides directly the 2‐oxo derivative (II); intramolecular O—H carbene insertion followed by cyclization allows the synthesis of 3‐oxo derivative (VI).
ChemInform Abstract: Iridium‐Catalyzed Triple C(sp3)—H Borylations: Construction of Triborylated sp3‐Carbon Centers.
Authors: Mita Tsuyoshi , Ikeda Yuto , Michigami Kenichi , Sato Yoshihiro
Published: October 2013

An unprecedented catalytic C(sp3)—H triborylation at a single carbon is achieved with the assistance of a nitrogen directing group.
ChemInform Abstract: Synthesis of Novel Nucleoside Analogue Phosphorothioamidate Prodrugs and in vitro Anticancer Evaluation Against RKO Human Colon Carcinoma Cells.
Authors: Liu Wei , Zhang Lin , Zhou Honggang , Yang Cheng , Miao Zhiwei , Zhao Yufen
Published: October 2013

Phosphorothioamidate prodrugs of pyrimidine nucleoside analogues are prepared and evaluated as inhibitors of RKO tumor cells in vitro.
ChemInform Abstract: Synthesis and Phase Stability of Metastable Bixbyite V2O3 Colloidal Nanocrystals.
Authors: Bergerud Amy , Buonsanti Rafaella , Jordan‐Sweet Jean L. , Milliron Delia J.
Published: October 2013

V2O3 nanocrystals with a cubic bixbyite structure are prepared from VO(acac)2, oleylamine, and oleic acid (N2 flow, 310—370 °C, 1 h) and characterized by XRD, TEM, and FTIR spectroscopy.
ChemInform Abstract: Data‐Driven Review of Thermoelectric Materials: Performance and Resource Considerations.
Authors: Gaultois Michael W. , Sparks Taylor D. , Borg Christopher K. H. , Seshadri Ram , Bonificio William D. , Clarke David R.
Published: October 2013

Review: a database of thermoelectric materials with more than 18000 data points is created on the basis of information from about 100 publications; 132 refs.
ChemInform Abstract: Sintering of Supported Metal Catalysts
Authors: Contreras Jose Luis , Fuentes Gustavo A.
Published: October 2013

Review: 73 refs.
ChemInform Abstract: Atomic Layer Deposition of Noble Metals ‐ New Developments in Nanostructured Catalysts
Authors: Lu Junling , Lei Yu , Elam Jeffrey W.
Published: October 2013

Review: 60 refs.
ChemInform Abstract: Solution‐Processable Metal Oxide Semiconductors for Thin‐Film Transistor Applications
Authors: Thomas Stuart R. , Pattanasattayavong Pichaya , Anthopoulos Thomas D.
Published: October 2013

Review: 126 refs.
ChemInform Abstract: Lanthanide‐Doped Luminescent Nanoprobes: Controlled Synthesis, Optical Spectroscopy, and Bioapplications
Authors: Liu Yongsheng , Tu Datao , Zhu Haomiao , Chen Xueyuan
Published: October 2013

Review: 364 refs.
ChemInform Abstract: Profiles in Chemistry: A Historical Perspective on the National Organic Symposium.
Authors: Fenlon Edward E. , Myers Brian J.
Published: October 2013

Review: 109 refs.
ChemInform Abstract: Non‐existence Fullerene Compounds
Authors: Salcedo Roberto
Published: October 2013

Review: 16 refs.
ChemInform Abstract: Acid Catalysis in Organic Synthesis
Authors: Yamamoto Hisashi
Published: October 2013

Review: 38 refs.
ChemInform Abstract: Biocatalysis in Organic Synthesis: New Items in the Chemist′s Toolbox — Critical Survey Covering the Years 2009—2011
Authors: Tessaro Davide
Published: October 2013

Review: recent developments in enzyme‐catalyzed organic synthesis; 43 refs.
ChemInform Abstract: Materials‐Based Receptors: Design Principle and Applications.
Authors: Singh Kamaljit , Sareen Divya , Kaur Paramjit , Miyake Hiroyuki , Tsukube Hiroshi
Published: October 2013

Review: 137 refs.
ChemInform Abstract: Chemical Kinetics and Inverse Modelling Problems
Authors: Martinez‐Luaces Victor
Published: October 2013

Review: 19 refs.
ChemInform Abstract: The Synthesis, Single‐Crystal Structure, Optical Absorption, and Resistivity of Th2GeSe5.
Authors: Koscielski Lukasz A. , Malliakas Christos D. , Sarjeant Amy A. , Ibers James A.
Published: October 2013

The title compound is synthesized ba solid state reaction of an equimolar mixture of the elements (evacuated silica tube, 1273 K, 99 h) followed by treatment in a Sb2Se3 flux under the same conditions.
ChemInform Abstract: Structural Assembly from Phosphate to Germanophosphate by Applying Germanate as a Binder
Authors: Huang Ya‐Xi , et al. et al.
Published: October 2013

The isotypic porous compounds K3[FeII4(HPO4)2] [Ge2O(OH)(PO4)4]·2H2O and K3[Cd4(HPO4)2] [Ge2O(OH)(PO4)4]·3H2O are prepared by solvothermal reaction of GeO, Fe or Cd(OAc)2, KCl, H3PO4, H2O, 1,2‐propanediol, and Et3N (autoclave, 190 °C, 5 d; ≈80% yield).
ChemInform Abstract: Synthesis, Characterization, Magnetic and Electrochemical Properties of a New 3D Hexa‐Copper‐Substituted Germanotungstate.
Authors: Li Yanzhou , Luo Jie , Zhang Yanting , Zhao Junwei , Chen Lijuan , Ma Pengtao , Niu Jingyang
Published: October 2013

A rare CuII6 sandwiched tungstate, Na2[Cu(dap)2]2[Cu(dap)2]{ [Cu6(H2O)2(dap)2] [B‐α‐GeW9O34]2 }·4H2O (dap: 1,2‐diaminopropane) is hydrothermally synthesized from a mixture of K8Na2[A‐α‐GeW9O34], CuCl2, Ce(NH4)4(SO4)4, dap, and H2O (autoclave, 160 °C, 5 d, 26% yield).
ChemInform Abstract: DBU‐Mediated Transformation of Arylmethylenecyclopropenes to Alkylidenecyclopropanes.
Authors: Sang Rui , Yang Hai‐Bin , Shi Min
Published: October 2013

The title reaction proceeds under mild conditions with good stereoselectivities in most cases.
ChemInform Abstract: Direct Asymmetric Aldol Reaction Co‐Catalyzed by Amphiphilic Prolinamide Phenol and Lewis Acidic Metal on Water.
Authors: Zhang Tao , Zhang Yunxiao , Li Zaichun , Song Zhongtai , Liu Hao , Tao Jingchao
Published: October 2013

The presented work suggests that Aldol catalysis with salt under hydrophilic conditions could provide a chiral influence in prebiotic chemistry.
ChemInform Abstract: Synthesis of 2‐Alkyl‐2‐arylcyanoacetates via Cul/Sodium Picolinate‐Catalyzed Direct Arylation of α‐Substituted Cyanoacetates.
Authors: Xie Siwei , Qin Peng , Li Meng , Zhang Xiaojing , Jiang Yongwen , Ma Dawei
Published: October 2013

Various aryl iodides and a wide range of functionalized α‐substituted cyanoacetates are compatible with the optimized reaction conditions.
ChemInform Abstract: Copper‐Catalyzed Sulfonamides Formation from Sodium Sulfinates and Amines.
Authors: Tang Xiaodong , Huang Liangbin , Qi Chaorong , Wu Xia , Wu Wanqing , Jiang Huanfeng
Published: October 2013

Oxygen or DMSO act as oxidants in this copper‐catalyzed reaction.
ChemInform Abstract: One‐Pot Synthesis of Aromatic Fused 2,3‐Dihydroindanone by Tandem Pauson—Khand/Michael/Henry Reaction.
Authors: Li Mingming , Xing Ping , Huang Zuogang , Jiang Biao
Published: October 2013

The scaffold of the products is build up from a CO ligand, ethylene, and nitromethane.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Regio‐ and Diastereoselective Diarylating Carbocyclization of Dienynes.
Authors: Jiang Min , Baeckvall Jan‐E.
Published: October 2013

The reaction of a cyclodienyne is unsuccessful under this reaction conditions.
ChemInform Abstract: Enantioselective Thiourea‐Catalyzed Intramolecular Cope‐Type Hydroamination.
Authors: Brown Adam R. , Uyeda Christopher , Brotherton Carolyn A. , Jacobsen Eric N.
Published: October 2013

The catalyzed Cope‐type rearrangement provides highly enantioselective α‐substituted pyrrolidines under mild reaction conditions.
ChemInform Abstract: Polyethylene Glycol (PEG‐400): A Mild and Efficient Reaction Medium for One‐Pot Synthesis of 3‐Hydroxy‐3‐(pyridin‐2‐ylmethyl)indolin‐2‐ones.
Authors: Raghu M. , Rajasekhar M. , Reddy B. Chandra Obula , Reddy C. Suresh , Reddy B. V. Subba
Published: October 2013

A facile synthesis of the title compounds is achieved from isatins and different methylpyridines without the need of any additive or acid catalyst.
ChemInform Abstract: Enantioselective Decarboxylative Aldol Addition of β‐Ketoacids to Isatins Catalyzed by Binaphthyl‐Modified Organocatalyst.
Authors: Suh Chang Won , Chang Chul Woo , Choi Keon Woong , Lim Young Jo , Kim Dae Young
Published: October 2013

Optimized reaction conditions using a squaric acid diamide derivative as the catalyst are developed for the title reaction to afford phenacyloxindole derivatives with excellent enantioselectivity.
ChemInform Abstract: Diastereoselective Synthesis of Ring‐Fused Thiocarbamates Bearing Contiguous Quaternary Carbon Centers.
Authors: Guo Qi‐Xiang , Zhang Li‐Jun , Song Liu , Xu Biao , Xiao Dong‐Rong , Peng Yun‐Gui
Published: October 2013

The DMAP‐catalyzed tandem aldol/imidization reaction of α‐isothiocyanato esters with α‐ketoamides affords diastereomerically pure bicyclic heterocycles bearing contiguous tetrasubstituted carbon centers.
ChemInform Abstract: Evaluation of the Synthesis of 1‐(Pentafluorophenyl)‐4,5‐dihydro‐1H‐pyrazoles Using Green Metrics.
Authors: Frizzo Clarissa P. , et al. et al.
Published: October 2013

Title compounds (III) are synthesized by cyclocondensation reaction under microwave irradiation as well as conventionally in ionic liquid solution.
ChemInform Abstract: Synthesis, in vitro Antimicrobial and Antioxidant Activities of Some New 4,5‐Dihydro‐1H‐1,2,4‐triazol‐5‐one Derivatives.
Authors: Yueksek Haydar , Akyildirim Onur , Yola Mehmet L. , Guersoy‐Kol Oezlem , Celebier Mustafa , Kart Didem
Published: October 2013

The compounds (III) and (V) are tested for their potential in vitro antioxidant activity and the compound (IIId) shows best activity for iron binding.
ChemInform Abstract: Catalyzed Claisen Rearrangements of O‐Allyl Kojates.
Authors: Pirrung Michael C. , Nalbandian Jenifer N.
Published: October 2013

Zinc triflate is reported as an useful catalyst for the Claisen rearrangement of O‐allylic kojic acid ethers.
ChemInform Abstract: One‐Pot Synthesis of Polysubstituted 2‐Piperidinones from Aromatic Aldehydes, Nitromethane, Ammonium Acetate, and Dialkyl Malonates.
Authors: Liu Hui , Sun Qian , Zhou Zhengquan , Liu Juanjuan , Yang Jing , Wang Cunde
Published: October 2013

Title compounds [(IV) and (VI)] are stereoselectively synthesized via pseudo‐five‐component reaction.
ChemInform Abstract: Ruthenium‐Catalyzed Aerobic Oxidative Cyclization of Aromatic and Heteroaromatic Nitriles with Alkynes: A New Route to Isoquinolones.
Authors: Reddy Mallu Chenna , Manikandan Rajendran , Jeganmohan Masilamani
Published: October 2013

Unsymmetrically substituted alkynes (XIII) are found to regioselectively react in a fashion where the less hindered C‐H bond of the aromatic nitrile is preferably attacked by the alkyl substituted site of the alkyne.
ChemInform Abstract: A Catalytic Asymmetric Synthesis of Polysubstituted Piperidines Using a Rhodium(I)‐Catalyzed [2 + 2 + 2] Cycloaddition Employing a Cleavable Tether.
Authors: Martin Timothy J. , Rovis Tomislav
Published: October 2013

The Rh‐catalyzed [2 + 2 + 2] cycloaddition of oxygen or nitrogen linked alkenyl isocyanates (I) and (IV) and terminal alkynes proceeds with high enantioselectivity in the presence of an electron‐withdrawing phosphoramidite ligand.
ChemInform Abstract: Friedlaender Synthesis of Novel Benzopyranopyridines in the Presence of Chitosan as Heterogeneous, Efficient and Biodegradable Catalyst under Solvent‐Free Conditions.
Authors: Siddiqui Zeba N. , Khan Kulsum
Published: October 2013

Title compounds such as (III), (V), (VII), (IX), (XI), (XIII) and (XV) are prepared from coumarin (I) and corresponding active methylene compounds.
ChemInform Abstract: A Facile and Efficient Synthesis of Tetrahydro‐β‐carbolines.
Authors: Desroses Matthieu , Koolmeister Tobias , Jacques Sylvain , Llona‐Minguez Sabin , Jacques‐Cordonnier Marie‐Caroline , Cazares‐Koerner Armando , Helleday Thomas , Scobie Martin
Published: October 2013

The T3P‐promoted reaction of tryptamides with aldehydes under microwave irradiation allows the access to a broad spectrum of the N‐heterocyclic systems as alkaloid substructures and drug skeletons.
ChemInform Abstract: Microwave Assisted Palladium‐Catalyzed Synthesis of Phthalazinones and Pyridopyridazinones
Authors: Rao K. Penta , Basak Ashok K. , Deb Prasant K. , Sharma Somesh , Reddy L. Krishnakanth
Published: October 2013

from o‐bromobenzaldehydes, arylhydrazines, and Mo(CO)6 as a non‐toxic alternative for CO
ChemInform Abstract: Convenient One‐Pot Synthesis of N3‐Substituted Pyrido[2,3‐d]‐, Pyrido[3,4‐d]‐, Pyrido[4,3‐d]‐pyrimidin‐4(3H)‐ones, and Quinazolin‐4(3H)‐ones Analogues.
Authors: Deau Emmanuel , Hedou Damien , Chosson Elizabeth , Levacher Vincent , Besson Thierry
Published: October 2013

The process allows the conversion of anthranilic acids as well as aminonicotinic acid and derivatives into the required heteroaromatic compounds.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Glyoxals by Oxidation of Terminal Alkynes: One‐Pot Synthesis of Quinoxalines.
Authors: Shi Shuai , Wang Tao , Yang Weibo , Rudolph Matthias , Hashmi A Stephen K.
Published: October 2013

The title synthesis represents an attractive alternative to classical procedures.
ChemInform Abstract: A Rapid and Simple Diversity‐Oriented Synthesis of Novel 3‐Amino‐2′‐oxospiro[benzo[c]pyrano [3,2‐a]phenazine‐1,3′‐indoline]‐2‐carbonitrile/carboxylate Derivatives via a One‐Pot, Four‐Component Domino Reaction.
Authors: Mahdavinia Gholam Hossein , Mirzazadeh Maryam , Notash Behrouz
Published: October 2013

The title products are formed through a double C=N bond formation/Knoevenagel condensation/Michael addition/cyclization sequence.
ChemInform Abstract: ZnS Nanoparticles: An Efficient Catalyst for the One‐Pot Synthesis of Spiro[pyrrolidine‐2,3′‐oxindole] Derivatives from Phenothiazinyl Chalcones.
Authors: Ameta K. L. , Kumar Biresh , Rathore Nitu S.
Published: October 2013

ZnS nanoparticles efficiently catalyze the three‐component one‐pot synthesis of spiro title compounds of type (VI).
ChemInform Abstract: Building Functionality Through Sequential C—B and C—F Bond Formation.
Authors: Palau‐Lluch Gerard , Fernandez Elena
Published: October 2013

Two efficient synthetic protocols are elaborated for the preparation of regioisomeric fluoro‐boryl‐ketones (III) or (IV)/(V).
ChemInform Abstract: Amide‐Controlled Highly Selective Catalytic Borylcupration of Allenes.
Authors: Yuan Weiming , Zhang Xue , Yu Yihua , Ma Shengming
Published: October 2013

The novel copper‐catalyzed borylcupration of disubstituted 2,3‐allenamides (I) with bis(pinacolato)diboron produces Z‐β‐borylated β,γ‐unsaturated enoamides (III) with high regio‐ and stereoselectivity.
ChemInform Abstract: Synthesis and Biological Evaluation of New Paclitaxel Analogues and Discovery of Potent Antitumor Agents.
Authors: Nicolaou Kyriacos C. , Valiulin Roman A.
Published: October 2013

A series of new paclitaxel analogues, such as (I)—(IV) is synthesized and screened for their cytotoxic activity.
ChemInform Abstract: Dysoxylumasins A—F: Six New Limonoids from Dysoxylum mollissimum Bl.
Authors: Xu Jinbiao , Ni Gang , Yang Shengping , Yue Jianmin
Published: October 2013

isolation and structures elucidation of dysoxylumasins A—F (I—IV)
ChemInform Abstract: An Efficient Procedure for the Synthesis of 2,3‐Unsaturated‐O‐glycosides: TiCl3(OTf) as the Catalyst for Type I Ferrier Rearrangement.
Authors: Chen Peiran , Lin Lei
Published: October 2013

The Ferrier rearrangement is performed with glucal (I) and a variety of structurally different alcohols.
ChemInform Abstract: Comparative Study of the Frech Catalyst with Two Conventional Catalysts in the Heck Synthesis of 2,4‐Diaminopyrimidine‐Based Antibiotics.
Authors: Nammalwar Baskar , Bunce Richard A. , Berlin K. Darrell , Bourne Christina R. , Bourne Philip C. , Barrow Esther W. , Barrow William W.
Published: October 2013

The Frech catalyst proves to be superior to conventional palladium‐based Heck catalysts, giving the desired products (III) and (V) in higher yields with fewer contaminants.
ChemInform Abstract: Preparation of Calcium Magnesium Acetate (CMA) Deicing Agent Using Waste Eggshell as Raw Materials.
Authors: Yang Li , Yan Qinghua , Ma Xiaoqin , Luo Tianjun , Wang Tianxi
Published: October 2013

Calcium magnesium acetate deicing salt is prepared from waste egg shell (about 96% CaCO3 and 1% MgCO3) by calcination at 1000 °C (1 h) followed by adjustment of the Ca/Mg molar ratio with MgO to 0.6 and neutralization with glacial AcOH.
ChemInform Abstract: Surface and Interface Control of Noble Metal Nanocrystals for Catalytic and Electrocatalytic Applications
Authors: Wu Binghui , Zheng Nanfeng
Published: October 2013

Review: 354 refs.
ChemInform Abstract: Gold Nanoparticles Functionalized with Supramolecular Macrocycles
Authors: Li Hui , Yang Ying‐Wei
Published: October 2013

Review: 67 refs.
ChemInform Abstract: Ti‐Substituted Zeolite Beta: A Milestone in the Design of Large Pore Oxidation Catalysts
Authors: De Baerdemaeker T. , Steenackers B. , De Vos D.
Published: October 2013

Review: 33 refs.
ChemInform Abstract: Isatin as a Strategic Motif for Asymmetric Catalysis
Authors: Mohammadi Somayeh , Heiran Roghayeh , Herrera Raquel , Marques‐Lopez Eugenia
Published: October 2013

Review: <125 refs.
ChemInform Abstract: Quinoline Derivatives
Authors: Cherian Ayda , Ramjith U. S.
Published: October 2013

Review: chemistry and pharmacological activities; 43 refs.
ChemInform Abstract: Identification of Post‐Translational Modifications by Mass Spectrometry
Authors: Ngounou Wetie Armand G. , Sokolowska Izabela , Woods Alisa G. , Darie Costel C.
Published: October 2013

Review: 139 refs.
ChemInform Abstract: Artificial Metalloenzymes Constructed from Hierarchically‐Assembled Proteins
Authors: Ueno Takafumi , Tabe Hiroyasu , Tanaka Yuya
Published: October 2013

Review: 121 refs.
Construction and Test of a Gradient System for NMR Diffusion Studies in Interface Systems
Authors: Schlayer Stefan , Stallmach Frank , Horch Carsten , Splith Tobias , Pusch Anne‐Kristin , Pielenz Frederike , Peksa Mikulás
Published: October 2013

Für NMR‐Diffusionsmessungen wurde ein z‐Gradientensystem zur Erzeugung intensiver Feldgradientenimpulse überarbeitet. Dazu wurde das Gradientenfeld einer aktiv abgeschirmten Spule mittels der Finite‐Elemente‐Methode optimiert. Das System wurde aus Glaskeramik als Spulenträger aufgebaut. Es besitzt kein 1H‐NMR‐Eigensignal und weist einen hohen Strom/Gradienten‐Wandlerfaktor von 0,37 T m–1A–1 auf. Mit dem Nachweis isotroper und anisotroper Diffusion in wässrigen Lösungen eines PEO‐PPO‐PEO Triblock‐Copolymers und adsorbierten Methans in zwei verschiedenen mikroporösen kristallinen Adsorbentien wird die Funktionstüchtigkeit des Systems demonstriert.
Atom für Atom
Authors: Sperl Alexander , Kröger Jörg , Berndt Richard
Published: October 2013

Mit Hilfe der Spitze eines Rastertunnelmikroskops wird ein einzelnes metallfreies Phthalocyanin‐Molekül in ein Silber‐Phthalocynanin auf einer Obefläche umgewandelt. Die Reaktionsschritte erfolgen Atom für Atom. Jedes Zwischenprodukt kann mit Hilfe von rastertunnelmikroskopischen Aufnahmen analysiert werden. Neben der schrittweisen Molekülumwandlung sind die Tautomerisierung und das H‐Hüpfen, die kontrolliert durch Injektion von Elektronen induziert werden, weitere Beispiele für die Präzision eines modernen Rastertunnelmikroskops.
Hydrothermal Self‐assembly Synthesis of Mn3O4/Reduced Graphene Oxide Hydrogel and Its High Electrochemical Performance for Supercapacitors
Authors: Li Li , Hu Zhongai , Yang Yuying , Liang Pengju , Lu Ailian , Xu Huan , Hu Yingying , Wu Hongying
Published: October 2013

In the present work Mn3O4/reduced graphene oxide hydrogel (Mn3O4‐rGOH) with three dimensional (3D) networks was fabricated by a hydrothermal self‐assembly route. The morphology, composition, and microstructure of the as‐obtained samples were characterized using powder X‐ray diffraction (XRD), X‐ray photoelectron spectroscopy (XPS), thermogravimetry analysis (TG), atomic absorption spectrometry (AAS), field emission scanning electron microscopy (FESEM) and transmission electron microscope (TEM). Moreover, the electrochemical behaviors were evaluated by cyclic voltammogram (CV), galvanostatic charge‐discharge and electrochemical impedance spectroscopy (EIS). The test results indicated that the hydrogel with 6.9% Mn3O4 achieved specific capacitance of 148 F·g−1 at a specific current of 1 A·g−1, and showed excellent cycling stability with no decay after 1200 cycles. In addition, its specific capacitance could retain 70% even at 20 A·g−1 in comparison with that at 1 A·g−1 and the operating window was up to 1.8 V in a neutral electrolyte.
Insight into the Structural Requirements of Protoporphyrinogen Oxidase Inhibitors: Molecular Docking and CoMFA of Diphenyl Ether, Isoxazole Phenyl, and Pyrazole Phenyl Ether
Authors: Yang Shenggang , Hao Gefei , Dayan Franck E. , Tranel Patrick J. , Yang Guangfu
Published: October 2013

Protoporphyrinogen oxidase (PPO, EC 1.3.3.4) is one of the most significant targets for a large family of inhibitors that may be used as herbicide, bactericide, fungicide, or photosensitizing activator to treat cancer through photodynamic therapy (PDT). Molecular docking and CoMFA were combined in a multistep framework with the ultimate goal of identifying important factor contributing to the activity of PPO inhibitors. As a continuation of the previous research work on the development of new PPO inhibitors, the bioassay results indicated that good PPO inhibitors were discovered in all of the three chemical series with IC50 values ranging from 0.010 to 0.061 µmol·L−1. Using the crystal structure of tobacco mitochondrial PPO (mtPPO) as template, all the compounds were docked into the enzyme active site. The docking pose of each compound was subsequently used in a receptor‐based alignment, leading to the development of a significant CoMFA model with r2 value of 0.98 and q2 (cross validation r2) value of 0.63. This novel multistep framework gives insight into the structural characteristics for the binding of inhibitors, and it can be extended to other classes of PPO inhibitors. In addition, the simplicity of the proposed approach may be particularly applicable in virtual screening procedures.
Investigation on the Coordination Mode of IL‐Supported Diols Used as Phosphine‐Free Ligands for Palladium Catalyzed Heck Reaction
Authors: Cai Yueqin , Song Gonghua , Chen Xiao
Published: October 2013

The coordination mode of IL‐supported diols used as phosphine‐free ligands for palladium catalyzed Heck reaction has been investigated by tuning their compositions. The difference in coordination of these IL‐supported diols with metal Pd in Heck reaction was related to the changes of the cation rings, leading to the different activities of Pd catalyst in the reaction. The experimental results indicated that the activities of Pd catalyst were affected mainly by π‐electron density of the cation rings. Compared to pyridinium and piperidinium cations, imidazolium cations showed the best coordination to metal Pd. In the meantime, C‐2 hydrogen and the length of alkyl side chains had impacts on the coordination as well.
Synthesis and Physical Properties of Benzopyridazine‐Based Conjugated Molecules
Authors: Su Yuezeng , Xu Wei , Qiu Feng , Wu Dongqing , Liu Ping , Xue Minzhao , Zhang Fan
Published: October 2013

A series of novel organic conjugated molecules (5a–5d) comprising 2,3‐benzopyridiazine as electron‐withdrawing core and thiophene derivatives as electron‐donating arms have been synthesized successfully in good yields. The ultraviolet‐visible (UV‐Vis) absorption spectra and fluorescence spectra of 5a–5d revealed that the optical properties are strongly influenced by the interactions between nitrogen and sulfur atoms in the conjugated backbone, as well as the position of the alkyl chains in the thiophene rings. The experimental results and theoretical calculation data clearly indicated that the band gap and the energy levels of LUMO and HOMO could be fine‐tuned by the position of alkyl chains in the thiophene rings. Thus, the structure‐property correlation of this class of conjugated molecules can be well established.
Gender‐Related Safety and Efficacy of Cardiac Resynchronization Therapy
Authors: Schuchert Andreas , Muto Carmine , Maounis Themistoklis , Frank Robert , Ella Rita Omega , Polauck Alexander , Padeletti Luigi ,   for the MASCOT Study Group
Published: October 2013

Background

Cardiac resynchronization therapy (CRT) is an established therapy for patients with chronic heart failure (CHF) and a broad QRS complex. Gender‐related safety and efficacy data are necessary for informed patient decision‐making for female patients with CHF. The aim of the study was to assess the effects of gender on the outcome of CRT in highly symptomatic heart failure patients.

Hypothesis

Gender may have an effect on the outcome of heart failure patients undergoing cardiac resynchronisation therapy.

Methods

The study analyzed the 2‐year follow‐up of 393 New York Heart Association (NYHA) class III/IV patients with a class I CRT indication enrolled in the Management of Atrial Fibrillation Suppression in AF‐HF Comorbidity Therapy (MASCOT) study.

Results

In female patients (n = 82), compared with male patients (n = 311), CHF was more often due to dilated cardiomyopathy (74% vs 44%, respectively; P < 0.0001). Females also had a more impaired quality‐of‐life score and a smaller left ventricular end‐diastolic diameter (LVEDD). Women were less likely than men to have received a CRT defibrillator (35% vs 61%, respectively; P < 0.0001). After 2 years, the devices had delivered more biventricular pacing in women than in men (96% ± 13% vs 94% ± 13%, respectively; P < 0.0004). Women had a greater reduction in LVEDD than did men (−8.2 mm ± 11.1 mm vs −1.1 mm ± 22.1 mm, respectively; P < 0.02). Both genders improved similarly in NYHA functional class. Women reported greater improvement than men in quality‐of‐life score (−21.1 ± 26.5 vs −16.2 ± 22.1, respectively; P < 0.0001). After adjustment for cardiovascular history, women had lower all‐cause mortality (P = 0.0007), less cardiac death (P = 0.04), and fewer hospitalizations for worsening heart failure (P = 0.01).

Conclusions

Females exhibited a better response to CRT than did males. Because females have such impressive benefits from CRT, improved screening and advocacy for CRT implantation in women should be considered.
Heart Failure in Patients With Atrial Fibrillation Is Associated With a High Symptom and Hospitalization Burden: The RealiseAF Survey
Authors: Silva‐Cardoso José , Zharinov Oleg J. , Ponikowski Piotr , Naditch‐Brûlé Lisa , Lewalter Thorsten , Brette Sandrine , Steg P. Gabriel ,   on behalf of the RealiseAF Investigators
Published: October 2013

Background

Atrial fibrillation (AF) and heart failure (HF) often coexist; the consequences of such coexistence are unclear.

Hypothesis

HF in patients with AF is associated with poor outcomes.

Methods

This post hoc analysis of RealiseAF, a survey of AF patients, compared symptoms, hospitalizations, management, and AF control in patients with vs without HF. A total of 10,523 AF patients were analyzed according to presence/absence of HF.

Results

History of HF was present in 45.8%, and in more patients with permanent vs persistent, paroxysmal, or first‐episode AF (55.6%, 44.3%, 32.9%, and 29.8%, respectively; P < 0.0001). Patients with vs those without history of HF, and patients with HF and reduced ejection fraction (HF‐REF) vs those with HF and a preserved ejection fraction (HF‐PEF), had more frequent cardiovascular (CV) risk factors and more severe symptoms. Presence vs absence of HF, and HF‐REF vs HF‐PEF, were associated with lower rates of AF control (54.6% vs 62.8% and 49.3% vs 60.3%, respectively; both P < 0.0001). The rate‐control strategy was used more frequently in HF patients, particularly those with HF‐REF, than the rhythm‐control strategy. CV hospitalizations occurred more frequently in patients with HF than those without (41.8% vs 17.5%; P < 0.001) and more frequently in patients with HF‐REF than in those with HF‐PEF (51.6% vs 35.6%; P < 0.0001).

Conclusions

AF patients with HF, particularly HF‐REF, experience heavy symptom and hospitalization burdens, and have relatively low rates of AF control. Further studies are needed to identify ways to improve the management and treatment outcomes of this very high‐risk patient population.
Differences in outcomes of newly diagnosed acute myeloid leukemia for adolescent/young adult and younger patients
Authors: Canner Jason , Alonzo Todd A. , Franklin Janet , Freyer David R. , Gamis Alan , Gerbing Robert B. , Lange Beverly J. , Meshinchi Soheil , Woods William G. , Perentesis John , Horan John
Published: October 2013

BACKGROUND

Studies comparing survival of adolescent and young adult (AYA) patients to that of younger patients with newly diagnosed acute myeloid leukemia (AML) have yielded conflicting results. In order to more accurately characterize relative survival and other outcomes of AYA patients, a cross‐study analysis was conducted using data from recent trials conducted by the Children's Cancer Group (CCG) and Children's Oncology Group (COG).

METHODS

Data were combined from the CCG‐2891, CCG‐2941, CCG‐2961, and AAML03P1 trials. The data set included 1840 patients, comprising 238 AYA and 1602 younger patients.

RESULTS

Overall survival was not significantly different in the 2 groups (AYA, 49% ± 7% versus younger, 54% ± 3% (± 2 standard errors), P = .058). Relapse was lower in AYA patients (30% ± 7% versus 41% ± 3%, P = .002), but treatment‐related mortality (TRM) was higher (25% ± 6% versus 12% ± 2%, P < .001). After adjustment for other factors, older age remained strongly associated with TRM (hazard ratio = 2.30, 95% CI = 1.59‐3.33, P < .001). Infection accounted for the excess TRM in AYA patients.

CONCLUSIONS

Survival in AYA and younger patients with newly diagnosed AML is similar; however, older patients are at higher risk for TRM. More effective strategies for preventing mortality from infection in AYA patients are needed. Cancer 2013;119:4162–4169. © 2013 American Cancer Society.
Randomized phase 2 study of pegylated SN‐38 (EZN‐2208) or irinotecan plus cetuximab in patients with advanced colorectal cancer
Authors: Garrett Christopher R. , Bekaii‐Saab Tanios S. , Ryan Theresa , Fisher George A. , Clive Sally , Kavan Petr , Shacham‐Shmueli Einat , Buchbinder Aby , Goldberg Richard M.
Published: October 2013

BACKGROUND

Irinotecan is cytotoxic in patients with advanced colorectal cancer (CRC). SN‐38 (10‐hydroxy‐7‐ethyl‐camptothecin) is the active metabolite of irinotecan. Attachment of polyethylene glycol (PEG) polymer chains (pegylation) to SN‐38 (EZN‐2208) increases the solubility, exposure, and half‐life of SN‐38. Preclinical studies demonstrated superior in vitro efficacy of EZN‐2208 when it was tested in irinotecan‐refractory human CRC cell lines.

METHODS

Patients with metastatic or locally recurrent CRC who had previously received 5‐flurouracil (5‐FU), oxaliplatin, and irinotecan were assigned to receive EZN‐2208 monotherapy (9 mg/m2 on days 1, 8, and 15 every 28 days for patients with KRAS‐mutant tumors only [arm A]), and patients with KRAS wild‐type tumors were randomized (2:1) to receive either EZN‐2208 plus cetuximab (400 mg/m2 loading dose on day 1 followed by 250 mg/m2 weekly starting on day 8 [arm B]) or irinotecan 125 mg/m2 on days 1 and 8 every 21 days plus cetuximab at the same doses indicated above (arm C).

RESULTS

The overall response rate and progression‐free survival were 0% and 1.8 months, respectively, in arm A; 10.7% and 4.9 months (95% confidence interval [CI], 3.2‐5.8 months), respectively, in arm B; and 14.3% and 3.7 months (95% CI, 2.1‐5.8 months), respectively, in arm C. EZN‐2208 was well tolerated in combination with cetuximab. No statistically significant difference in survival was observed between arm B (9.8 months; 95% CI, 7.2‐11.2 months) and arm C (9.1 months; 95% CI, 6.0‐13.0 months).

CONCLUSIONS

EZN‐2208, either as monotherapy or in combination with cetuximab, was well tolerated in patients with refractory CRC. Overall survival and progression‐free survival were similar in the cetuximab plus irinotecan arm and the EZN‐2208 arm. Cancer 2013;119:4223–4230. © 2013 American Cancer Society.
Rebiopsy of non–small cell lung cancer patients with acquired resistance to epidermal growth factor receptor‐tyrosine kinase inhibitor
Authors: Hata Akito , Katakami Nobuyuki , Yoshioka Hiroshige , Takeshita Jumpei , Tanaka Kosuke , Nanjo Shigeki , Fujita Shiro , Kaji Reiko , Imai Yukihiro , Monden Kazuya , Matsumoto Takeshi , Nagata Kazuma , Otsuka Kyoko , Tachikawa Ryo , Tomii Keisuke , Kunimasa Kei , Iwasaku Masahiro , Nishiyama Akihiro , Ishida Tadashi , Nishimura Yoshihiro
Published: October 2013

BACKGROUND

The secondary epidermal growth factor receptor (EGFR) mutation Thr790Met (T790M) accounts for approximately half of acquired resistances to EGFR‐tyrosine kinase inhibitor (TKI). Recent reports have demonstrated that the emergence of T790M predicts a favorable prognosis and indolent progression. However, rebiopsy to confirm T790M status can be challenging due to limited tissue availability and procedural feasibility, and little is known regarding the differences among patients with or without T790M mutation.

METHODS

The study investigated 78 EGFR‐mutant patients who had undergone rebiopsy after TKI failure. The peptide nucleic acid–locked nucleic acid polymerase chain reaction clamp method was used in EGFR mutational analyses. Various patient characteristics and postprogression survivals (PPSs) after initial TKI failure were retrospectively compared in patients with and without T790M.

RESULTS

The T790M mutation was identified in 4 (17%) of 24 central nervous system lesions, and in 22 (41%) of 54 other lesions (P = .0417). No other characteristics had a statistical association with T790M prevalence. Median PPS was 31.4 months in 26 patients with T790M, and 11.4 months in 52 patients without T790M (P = .0017). In the multivariate analysis, statistically significant factors for longer PPS included T790M‐positive, good performance status, and no carcinomatous meningitis.

CONCLUSIONS

The emergence of T790M in central nervous system lesions was rare, compared with other lesions. Patients with T790M after TKI failure appear to have better prognoses than those without T790M. TKI rechallenge or continuous administration beyond progression may be effective after initial TKI failure. Cancer 2013;119:4325–4332. © 2013 American Cancer Society.
Data‐driven execution of fast multipole methods
Authors: Ltaief Hatem , Yokota Rio
Published: October 2013

Fast multipole methods (FMMs) have complexity, are compute bound, and require very little synchronization, which makes them a favorable algorithm on next‐generation supercomputers. Their most common application is to accelerate N‐body problems, but they can also be used to solve boundary integral equations. When the particle distribution is irregular and the tree structure is adaptive, load balancing becomes a non‐trivial question. A common strategy for load balancing FMMs is to use the work load from the previous step as weights to statically repartition the next step. The authors discuss in the paper another approach based on data‐driven execution to efficiently tackle this challenging load balancing problem. The core idea consists of breaking the most time‐consuming stages of the FMMs into smaller tasks. The algorithm can then be represented as a directed acyclic graph where nodes represent tasks and edges represent dependencies among them. The execution of the algorithm is performed by asynchronously scheduling the tasks using the queueing and runtime for kernels runtime environment, in a way such that data dependencies are not violated for numerical correctness purposes. This asynchronous scheduling results in an out‐of‐order execution. The performance results of the data‐driven FMM execution outperform the previous strategy and show linear speedup on a quad‐socket quad‐core Intel Xeon system.Copyright © 2013 John Wiley & Sons, Ltd.
Real‐Time Monitoring of the Dephosphorylating Activity of Protein Tyrosine Phosphatases Using Microarrays with 3‐Nitrophosphotyrosine Substrates
Authors: van Ameijde Jeroen , Overvoorde John , Knapp Stefan , den Hertog Jeroen , Ruijtenbeek Rob , Liskamp Rob M. J.
Published: October 2013

Phosphatases and kinases regulate the crucial phosphorylation post‐translational modification. In spite of their similarly important role in many diseases and therapeutic potential, phosphatases have received arguably less attention. One reason for this is a scarcity of high‐throughput phosphatase assays. Herein, a new real‐time, dynamic protein tyrosine phosphatase (PTP) substrate microarray assay measuring product formation is described. PTP substrates comprising a novel 3‐nitrophosphotyrosine residue are immobilized in discrete spots. After reaction catalyzed by a PTP a 3‐nitrotyrosine residue is formed that can be detected by specific, sequence‐independent antibodies. The resulting microarray was successfully evaluated with a panel of recombinant PTPs and cell lysates, which afforded results comparable to data from other assays. Its parallel nature, convenience, and low sample requirements facilitate investigation of the therapeutically relevant PTP enzyme family.
Increasing returns economics and generalized Pólya processes
Authors: BuendÍa Fernando
Published: October 2013

This article extends the traditional Pólya scheme consisting of one urn with two colors to the schemes where multiple independent and/or interdependent urns with multiple additions and/or withdraws and several independent and/or interdependent colors are considered. It also argues that with these schemes many complex economic systems subject to increasing returns can be formalized mathematically, for they allow for positive and negative feedbacks among many variables, “jumps,” “bad” behaved dynamics, dis continuities, and interrelation among systems. © 2013 Wiley Periodicals, Inc. Complexity 19: 21–37, 2013
On the induction period for crystallization in solute−solvent systems by polythermal method
Authors: Sangwal Keshra , Mielniczek‐Brzóska Ewa , Borc Jarosław
Published: October 2013

The data of induction period tin derived from the data of maximum undercooling ΔTmax at different cooling rates R for some solute−solvent systems at different saturation temperature T0 are discussed using classical and atomistic theories of three‐dimensional nucleation. In the case of potassium nitrate aqueous solutions the tin data are analyzed in terms of the maximum supersaturation ratio Smax calculated from temperature dependence of solubility and the maximum undercooling ΔTmax and the values of solid−solution interfacial energy γ and number i* of molecules in the stable critically‐sized nuclei predited from tin(lnSmax) and tin(ΔTmax) data are compared. These results revealed that: (1) the values of supersaturation calculated as lnS from solubility data are lower than the real values expected from the chemical potential difference Δμ and that the description of Δμ in terms of undercooling ΔTmax is realistic, and (2) analysis of induction period data for solute−solvent systems should be carried out using applied undercooling ΔT or maximum undercooling ΔTmax instead of the usually used lnS or lnSmax. Examination of tin(ΔTmax) data for different systems showed that: (1) the value of γ lies between 1.7 and 13.2 mJ/m2 while that of i* between 2 and 50, and (2) in several cases atomistic nucleation theory describes the tin(ΔTmax) data adequately.
Early‐Stage Comparative Sustainability Assessment of New Bio‐based Processes
Authors: Patel Akshay D. , Meesters Koen , den Uil Herman , de Jong Ed , Worrell Ernst , Patel Martin K.
Published: October 2013

Our increasing demand for materials and energy has put critical roadblocks on our path towards a sustainable society. To remove these roadblocks, it is important to engage in smart research and development (R&D). We present an early‐stage sustainability assessment framework that is used to analyze eight new bio‐based process alternatives developed within the CatchBio research consortium in the Netherlands. This assessment relies on a multi‐criteria approach, integrating the performance of chemical conversions based on five indicators into an index value. These indicators encompass economics, environmental impact, hazards and risks thereby incorporating elements of green chemistry principles, and techno‐economic and life cycle assessments. The analyzed bio‐based options target the production of fuels and chemicals through chemical catalysis. For each bio‐based process, two R&D stages (current laboratory and expected future) are assessed against a comparable conventional process. The multi‐criteria assessment in combination with the uncertainty and scenario analysis shows that the chemical production processes using biomass as feedstock can provide potential sustainability benefits over conventional alternatives. However, further development is necessary to realize the potential benefits from biomass gasification and pyrolysis processes for fuel production. This early stage assessment is intended as an input for R&D decision making to support optimal allocation and utilization of resources to further develop promising bio‐based processes.
Efficiency Enhancement of Dye‐Sensitized Solar Cells by the Addition of an Oxidizing Agent to the TiO2 Paste
Authors: Ko Kwan‐Woo , Lee Minoh , Sekhon S. S. , Balasingam Suresh Kannan , Han Chi‐Hwan , Jun Yongseok
Published: October 2013

The addition of various amounts of a strong oxidizing agent (3,5‐dinitrosalicyclic acid, DNSA) to TiO2 paste enhances the solar‐to‐electrical‐energy conversion efficiency of the corresponding dye‐sensitized solar cells (DSSCs). Maximum performance was obtained from a device that was fabricated by using a TiO2 paste with 2 wt % DNSA, which showed a short‐circuit current density of 17.88 mA cm−2, an open‐circuit voltage of 0.78 V, and an overall conversion efficiency of 9.62 %, which was an improvement in comparison to reference cells without DNSA. This improvement was rationalized in terms of the amount of residual carbon (formed due to the oxidation of binders) remaining on the TiO2 surface. Addition of a larger amount of oxidizing agent led to a smaller amount of residual carbon on the TiO2 surface. This smaller amount of residual carbon enhanced the adsorption of a larger number of dye molecules on the TiO2 surface. The addition of an oxidizing agent facilitated the removal of more residual organic species during the high‐temperature calcination process while causing no change in the surface morphology and microstructure of the TiO2 film.
Phase Transition in Dust Clusters with Different Charging Processes
Authors: Gueddaoui H. , Djebli M.
Published: October 2013

Random charging processes effects on ground‐state configurations and phase transition of a finite system have been investigated in terms of Hamiltonian system. The particles interact through a screened Yukawa potential and are confined by a two‐dimensional parabolic potential. Numerical simulation was performed at low temperature for charging processes by particles collection and by photoemission. Results show that the charge fluctuation changes significantly the ground‐state configurations only in the case of the photoemission charging process and give rise to a change on the melting characteristics. (© 2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)
A preliminary examination of a nonpurging compensatory eating disorder
Authors: Davis Heather A. , Holland Lauren A. , Keel Pamela K.
Published: October 2013

Objective

To evaluate correlates of a compensatory eating disorder (CED) characterized by recurrent nonpurging compensatory behaviors in the absence of objectively large binge episodes among normal weight individuals who endorse undue influence of weight/shape on self‐evaluation as possible indicators of clinical significance and distinctiveness.

Method

Women with CED (n = 20), women with bulimia nervosa (BN) (n = 20), and controls (n = 20) completed an interview and questionnaires assessing eating disorder and general psychopathology and weight history.

Results

Compared with controls, women with CED reported significantly greater body image disturbance and disordered eating, higher anxiety proneness, increased perfectionism, and greater weight suppression. Compared with BN, CED was associated with significantly less body image disturbance, disordered eating, weight suppression, and lower likelihood of being overweight in childhood. However, CED and BN did not differ on anxiety proneness or perfectionism.

Discussion

CED merits further examination to determine whether it is a clinically significant and distinct eating disorder. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2014; 47:239–243)