bluuebunny/crossref_metadata_2025 huggingface dataset:
Physiology, Diagnosis and Treatment of Cardiac Light Chain Amyloidosis
Authors: Stelmach-Gołdyś Agnieszka , Zaborek-Łyczba Monika , Łyczba Jakub , Garus Bartosz , Pasiarski Marcin , Mertowska Paulina , Małkowska Paulina , Hrynkiewicz Rafał , Niedźwiedzka-Rystwej Paulina , Grywalska Ewelina
Published: February 2022

AL (light-chain) amyloidosis is a systemic disease in which amyloid fibers are formed from kappa or lambda immunoglobulin light chains, or fragments thereof, produced by a neoplastic clone of plasmocytes. The produced protein is deposited in tissues and organs in the form of extracellular deposits, which leads to impairment of their functions and, consequently, to death. Despite the development of research on pathogenesis and therapy, the mortality rate of patients with late diagnosed amyloidosis is 30%. The diagnosis is delayed due to the complex clinical picture and the slow progression of the disease. This is the type of amyloidosis that most often contributes to cardiac lesions and causes cardiac amyloidosis (CA). Early diagnosis and correct identification of the type of amyloid plays a crucial role in the planning and effectiveness of therapy. In addition to standard histological studies based on Congo red staining, diagnostics are enriched by tests to determine the degree of cardiac involvement. In this paper, we discuss current diagnostic methods used in cardiac light chain amyloidosis and the latest therapies that contribute to an improved patient prognosis.
Incremental Value of Myocardial Work over Global Longitudinal Strain in the Surveillance for Cancer-Treatment-Related Cardiac Dysfunction: A Case–Control Study
Authors: Kosmala Wojciech , Negishi Tomoko , Thavendiranathan Paaladinesh , Penicka Martin , De Blois Jonathan , Murbræch Klaus , Miyazaki Sakiko , Shirazi Mitra , Santoro Ciro , Vinereanu Dragos , Cho Goo-Yeong , Hristova Krassimira , Popescu Bogdan A. , Kurosawa Koji , Izumo Masaki , Negishi Kazuaki , Przewlocka-Kosmala Monika , Marwick Thomas H.
Published: February 2022

The load dependence of global longitudinal strain (GLS) means that changes in systolic blood pressure (BP) between visits may confound the diagnosis of cancer-treatment-related cardiac dysfunction (CTRCD). We sought to determine whether the estimation of myocardial work, which incorporates SBP, could overcome this limitation. In this case–control study, 44 asymptomatic patients at risk of CTRCD underwent echocardiography at baseline and after oncologic treatment. CTRCD was defined on the basis of the change in the ejection fraction. Those with CTRCD were divided into subsets with and without a follow-up SBP increment >20 mmHg (CTRCD+BP+ and CTRCD+BP−), and matched with patients without CTRCD (CTRCD−BP+ and CTRCD−BP−). The work index (GWI), constructive work (GCW), wasted work (GWW), and work efficiency (GWE) were assessed in addition to the GLS. The largest increases in the GWI and GCW at follow-up were found in CTRCD−BP+ patients. The CTRCD+BP− patients demonstrated significantly larger decreases in GWI and GCW than their CTRCD+BP+ and CTRCD−BP− peers. ROC analysis for the discrimination of LV functional changes in response to increased afterload in the absence of cardiotoxicity revealed higher AUCs for GCW (AUC = 0.97) and GWI (AUC = 0.93) than GLS (AUC = 0.73), GWW (AUC = 0.51), or GWE (AUC = 0.63, all p-values < 0.001). GCW (OR: 1.021; 95% CI: 1.001–1.042; p < 0.04) was the only feature independently associated with CTRCD−BP+. Myocardial work is superior to GLS in the serial assessments in patients receiving cardiotoxic chemotherapy. The impairment of GLS in the presence of an increase in GWI and GCW indicates the impact of elevated afterload on LV performance in the absence of actual myocardial impairment.
Definition of an Artificial Reef Unit through Hydrodynamic and Structural (CFD and FEM) Models—Application to the Ares-Betanzos Estuary
Authors: Galdo María Isabel Lamas , Guerreiro María Jesús Rodríguez , Vigo Javier Lamas , Rodriguez Ismael Ameneiros , Lorenzo Ricardo Veira , Couce Juan Carlos Carral , Couce Luis Carral
Published: February 2022

The application of hydrodynamics to the definition of artificial reefs is of great interest since the positioning of the artificial reef modules on the sea floor alters the water velocity field, causing an appropriate circulation of nutrients and promoting a habitat for settling desired species. Nevertheless, the designs must be subjected to a structural calculation that will condition the constructive process to be applied. The present research proposes a methodology to determine the geometry of an artificial reef in terms of hydrodynamic and structural criteria. The solution proposed was analyzed through Computational Fluid Dynamics (CFD) and the Finite Element Method (FEM). Using concrete as base material for artificial reefs, four different dosages were proposed with different proportions of cement and water, leading to different mechanical properties, which determine different constructive strategies, such as dwell time in the mold. From the hydrodynamic point of view, it was found that the solution proposed provides a proper replacement of nutrients. From the structural point of view, it was found that the solution proposed does not need steel reinforcements in concrete, which improves the sustainability of the artificial reef. The four different concrete dosages will condition the constructive strategy through the dwelling time in the mold and, for any established production, the necessary number of molds (formworks).
Recent Advances in Alternaria Phytotoxins: A Review of Their Occurrence, Structure, Bioactivity, and Biosynthesis
Authors: Wang He , Guo Yanjing , Luo Zhi , Gao Liwen , Li Rui , Zhang Yaxin , Kalaji Hazem M. , Qiang Sheng , Chen Shiguo
Published: February 2022

Alternaria is a ubiquitous fungal genus in many ecosystems, consisting of species and strains that can be saprophytic, endophytic, or pathogenic to plants or animals, including humans. Alternaria species can produce a variety of secondary metabolites (SMs), especially low molecular weight toxins. Based on the characteristics of host plant susceptibility or resistance to the toxin, Alternaria phytotoxins are classified into host-selective toxins (HSTs) and non-host-selective toxins (NHSTs). These Alternaria toxins exhibit a variety of biological activities such as phytotoxic, cytotoxic, and antimicrobial properties. Generally, HSTs are toxic to host plants and can cause severe economic losses. Some NHSTs such as alternariol, altenariol methyl-ether, and altertoxins also show high cytotoxic and mutagenic activities in the exposed human or other vertebrate species. Thus, Alternaria toxins are meaningful for drug and pesticide development. For example, AAL-toxin, maculosin, tentoxin, and tenuazonic acid have potential to be developed as bioherbicides due to their excellent herbicidal activity. Like altersolanol A, bostrycin, and brefeldin A, they exhibit anticancer activity, and ATX V shows high activity to inhibit the HIV-1 virus. This review focuses on the classification, chemical structure, occurrence, bioactivity, and biosynthesis of the major Alternaria phytotoxins, including 30 HSTs and 50 NHSTs discovered to date.
Multi-Task Deep Learning Approach for Simultaneous Objective Response Prediction and Tumor Segmentation in HCC Patients with Transarterial Chemoembolization
Authors: Li Yuze , Xu Ziming , An Chao , Chen Huijun , Li Xiao
Published: February 2022

This study aimed to develop a deep learning-based model to simultaneously perform the objective response (OR) and tumor segmentation for hepatocellular carcinoma (HCC) patients who underwent transarterial chemoembolization (TACE) treatment. A total of 248 patients from two hospitals were retrospectively included and divided into the training, internal validation, and external testing cohort. A network consisting of an encoder pathway, a prediction pathway, and a segmentation pathway was developed, and named multi-DL (multi-task deep learning), using contrast-enhanced CT images as input. We compared multi-DL with other deep learning-based OR prediction and tumor segmentation methods to explore the incremental value of introducing the interconnected task into a unified network. Additionally, the clinical model was developed using multivariate logistic regression to predict OR. Results showed that multi-DL could achieve the highest AUC of 0.871 in OR prediction and the highest dice coefficient of 73.6% in tumor segmentation. Furthermore, multi-DL can successfully perform the risk stratification that the low-risk and high-risk patients showed a significant difference in survival (p = 0.006). In conclusion, the proposed method may provide a useful tool for therapeutic regime selection in clinical practice.
Short-Term Efficacy of Transcranial Focused Ultrasound to the Hippocampus in Alzheimer’s Disease: A Preliminary Study
Authors: Jeong Hyeonseok , Song In-Uk , Chung Yong-An , Park Jong-Sik , Na Seung-Hee , Im Jooyeon Jamie , Bikson Marom , Lee Wonhye , Yoo Seung-Schik
Published: February 2022

Preclinical studies have suggested that low-intensity transcranial focused ultrasound (tFUS) may have therapeutic potential for Alzheimer’s disease (AD) by opening the blood–brain barrier (BBB), reducing amyloid pathology, and improving cognition. This study investigated the effects of tFUS on BBB opening, regional cerebral metabolic rate of glucose (rCMRglu), and cognitive function in AD patients. Eight patients with AD received image-guided tFUS to the right hippocampus immediately after intravenous injection of microbubble ultrasound contrast agents. Patients completed magnetic resonance imaging (MRI), 18F-fluoro-2-deoxyglucose positron emission tomography (PET), and cognitive assessments before and after the sonication. No evidence of transient BBB opening was found on T1 dynamic contrast-enhanced MRI. However, immediate recall (p = 0.03) and recognition memory (p = 0.02) were significantly improved on the verbal learning test. PET image analysis demonstrated increased rCMRglu in the right hippocampus (p = 0.001). In addition, increases of hippocampal rCMRglu were correlated with improvement in recognition memory (Spearman’s ρ = 0.77, p = 0.02). No adverse event was observed. Our results suggest that tFUS to the hippocampus of AD patients may improve rCMRglu of the target area and memory in the short term, even without BBB opening. Further larger sham-controlled trials with loger follow-up are warranted to evaluate the efficacy and safety of tFUS in patients with AD.
A Workload-Balancing Order Dispatch Scheme for O2O Food Delivery with Order Splitting Choice
Authors: Wang Ke , Zhou Yulin , Zhang Lingzhen
Published: February 2022

Online-to-offline (O2O) food delivery service refers to an emerging modern business model that enables customers to order foods from local restaurants via an online platform, and then receive and enjoy them offline after the delivery, offered by couriers. Such service, discussed in this article, specifies that a customer can order from multiple restaurants in a single order and choose for them to be delivered together or separately, whereas the commonly discussed mode only permits placing an order in one restaurant at once. In this service, one crucial issue is how to dispatch these orders to couriers for offline delivery. For this, we propose a new three-stage order dispatch scheme, namely, pseudo-assign first, re-route second, and courier selection last, aiming to deliver the orders in time and balance the couriers’ workload. Due to the dynamism and uncertainty inherently involved in this issue, we also take responsiveness to future demands and robustness into consideration when making the dispatch. Compared with existing approaches, the new one significantly balances the couriers’ workload and, meanwhile, keeps good performance in delay rate, making the decisions more practical. Furthermore, this study analyzes the influence of customers’ preference for order splitting and number of couriers on the efficiency of the distribution system, thereby interesting managerial insights for O2O food delivery are revealed.
Fire Occurrence in Hemi-Boreal Forests: Exploring Natural and Cultural Scots Pine Fire Regimes Using Dendrochronology in Lithuania
Authors: Manton Michael , Ruffner Charles , Kibirkštis Gintautas , Brazaitis Gediminas , Marozas Vitas , Pukienė Rūtilė , Makrickiene Ekaterina , Angelstam Per
Published: February 2022

Fire is an important natural disturbance and a driver of hemi-boreal forest successional trajectories, structural complexity, and biodiversity. Understanding the historic fire regime is an important step towards sustainable forest management. Focusing on Lithuania’s hemi-boreal forests, we first mapped the potential natural fire regimes based on the relationship between site conditions, vegetation, and fire frequency using the ASIO model. The ASIO model revealed that all the fire frequency categories (Absent, Seldom, Intermittent, Often) are found in Lithuania. Scots pine forests dominated the often fire frequency category (92%). Secondly, focusing on a fire-prone forest landscape, Dzūkija, we analyzed the fire occurrence of Scots pine forest types using dendrochronological records. We sampled and cross-dated 132 Scots pine samples with fire scars from four dry forest stands (n = 92) and four peatland forest stands (n = 40), respectively. In total, the fire history analysis revealed 455 fire scars and 213 fire events during the period of 1742–2019. The Weibull median fire intervals were 2.7 years (range 1–34) for the dry forest types and 6.3 years (range 1–27) for the peatland forest types. Analysis pre- and post-1950 showed the Weibull median fire interval increased from 2.2 to 7.2 for the dry forest types but decreased from 6.2 to 5.2. for the peatland forest types. A superposed epoch analysis revealed significant precipitation fluxes prior to the fire events after 1950. Thus, the Dzūkija landscape of Lithuania has been strongly shaped by both human and naturally induced fires. The combination of theory (the ASIO model) with the examination of biological archives can be used to help guide sustainable forest management to emulate forest disturbances related to fire. As traditional forest management focusing on wood production has eliminated fire, and effectively simplified forest ecosystems, we recommend introducing educational programs to communicate the benefits and history of forest fires as well as adaptive management trials that use low-intensity prescribed burning of Scots pine stands.
Cyclo-Tetrakis(μ-diphenylphosphido)-1,5-bis(tri-tert-butylphosphine)-Tetracopper
Authors: Dannenberg Steven G. , Waterman Rory
Published: February 2022

Copper phosphido compound Cu4(μ-PPh2)4(PtBu3)2 was synthesized by three synthetic methods and structurally characterized by X-ray diffraction and 1H, 31P, 13C and 31P HMBC NMR spectroscopy. Cu4(μ-PPh2)4(PtBu3)2 was also demonstrated to be a hydrophosphination pre-catalyst.
Effect on Microstructure and Mechanical Properties of Microwave-Assisted Sintered H13 Steel Powder with Different Vanadium Contents
Authors: Chen Xuebin , Zhao Lei , Wei Min , Huang Danqi , Jiang Liwu , Wang Haizhou
Published: February 2022

The present work demonstrated the first-ever preparation of block specimens by the microwave sintering of H13 alloy powder. Varying proportions of vanadium powder (1.5%, 2.5%, 3.5%, 4.5%, and 5.5% on a mass basis) were added to H13 mold steel and these mixtures were sintered using microwaves. X-ray fluorescence spectroscopy was employed to determine the compositions of the resulting specimens and vanadium percentages of 1.56%, 2.04%, 3.10%, 4.06%, and 4.20% were determined. These results demonstrate a clear trend, with significantly lower vanadium amounts than expected based on the nominal values at higher vanadium loadings. Different samples were also found to exhibit different degrees of ablation, and this effect was related to the presence of voids in the materials. The surface compositions of these specimens were examined by laser-induced breakdown spectroscopy and were found to be relatively uniform. The microstructures as well as the hardness properties of the materials were assessed. Microwave sintering of 100 g specimens at 1300 °C for 10-min generated samples with hardness values ranging from 205 HV (at the lowest vanadium content) to 175.2 HV (at the highest vanadium content). The wear behavior of samples prepared by microwave sintering H13 die steel with different vanadium contents at room temperature has been studied. The results showed that 1.5% vanadium content is the best mass ratio.
Microstructure and Phase Evolution Characteristics of the In Situ Synthesis of TiC-Reinforced AZ91D Magnesium Matrix Composites
Authors: Zhou Xinjun , Zhang Zhengfu , Li Xiulan , Zhou Liyu , Zhang Xudong , Chen Manjiao
Published: February 2022

TiC-reinforced AZ91D magnesium alloy composites were synthesized through the in situ reaction between an AZ91D melt and Ti-C-Al preforms. The microstructural evolution characteristics and phase transformation were investigated at different melt reaction temperatures (1013, 1033, and 1053 K), with the aim of understanding the in situ formation mechanism of TiC particles from thermodynamic and kinetic perspectives. The results showed that the temperature played a critical role in determining the formation and morphology of TiC. Initially, only the Al3Ti phase was formed through the reaction between Ti and Al when the temperature was 1013 K. With the increase in the melt temperature, the A13Ti’s thermodynamic stability decreased, and dissolution and precipitation reactions occurred at higher temperatures (1033 and 1053 K, respectively), contributing to the formation of TiC particles. The formation of the TiC phase was attributed to two factors: Firstly, A13Ti as an intermediate product reacted with carbon and formed TiC with increasing temperature. Secondly, the in situ TiC reaction was promoted due to the increased reaction-driving force provided by the increasing temperature.
Porous Biomass Carbon Derived from Clivia miniata Leaves via NaOH Activation for Removal of Dye
Authors: Gao Wei
Published: February 2022

Clivia miniata (CM), is an important ornamental plant and has been widely cultivated all over the world. However, there are no reports on Clivia miniata-based porous biomass carbon (CMBC). In this study, for the first time, CM leaves were used to generate porous biomass carbon via NaOH activation. The structures and surface characteristics were determined using scanning electron microscopy, N2 adsorption/desorption, TGA, FT-IR, X-ray diffraction, Raman and X-ray photoelectron spectra tests. CMBC has a large SSA (2716 m2/g) and a total pore volume of 1.95 cm3/g. To test the adsorption performance via adsorption experiments, the cationic and synthetic dye, malachite green (MG), was utilized as the adsorption model. The CMBC had a greatest adsorption capacity of 2622.9 mg/g at a pH value of 8 and had a fastest adsorption capacity of 1161.7 mg/g in the first 5 min. To explain MG adsorption into CMBC, the Freundlich isotherm and the pseudo-second-order kinetic model were used. The adsorption mechanism of MG was also investigated. After 10 cycles, the adsorption efficiency of CMBC to MG could still reach 85.3%. In summary, CMBC has excellent potential in dyeing wastewater pollution treatment.
Investigation of Degradation of Composites Based on Unsaturated Polyester Resin and Vinyl Ester Resin
Authors: Pączkowski Przemysław , Puszka Andrzej , Gawdzik Barbara
Published: February 2022

This study compares the degradation process of unsaturated polyester resin (UPR) and vinyl ester resin (VER) and their biocomposites with kraft lignin. In order to study their degradation, accelerated aging, immersion in different solvents, microwave radiation and high temperature were applied. The results show that, depending on the conditions, the degradation assumes a different course. The VER resin is more chemically resistant than the UPR resin. In the case of the composites immersed in an aggressive solvent (acetone), it can be observed that the polymer matrix is degraded, whereas in water only a small increase of weight takes place. Immersion in NaOH initiates the degradation process consisting in the hydrolysis of ester bonds, which are especially observed for pure resins. Under the influence of UV radiation and microwaves, the resins are additionally cross-linked. Thermogravimetric analysis shows that in the case of composites heated to 1000 °C, a residual mass remains, which is carbonized with lignin. In turn, composites treated with microwaves lost weight.
Correction: Jun et al. Improvement of Osseointegration by Ultraviolet and/or Simvastatin Treatment on Titanium Implants with or without Bone Graft Materials. Materials 2021, 14, 3707
Authors: Jun Ji Hoon , Oh Kyung Chul , Park Kyu-Hyung , Jung Narae , Li Jiayi , Moon Hong Seok
Published: February 2022

In the published publication [...]
Pessimistic Multigranulation Roughness of a Fuzzy Set Based on Soft Binary Relations over Dual Universes and Its Application
Authors: Din Jamalud , Shabir Muhammad , Wang Ye
Published: February 2022

The rough set model for dual universes and multi granulation over dual universes is an interesting generalization of the Pawlak rough set model. In this paper, we present a pessimistic multigranulation roughness of a fuzzy set based on soft binary relations over dual universes. Firstly, we approximate fuzzy set w.r.t aftersets and foresets of the finite number of soft binary relations. As a result, we obtained two sets of fuzzy soft sets known as the pessimistic lower approximation of a fuzzy set and the pessimistic upper approximation of a fuzzy set—the w.r.t aftersets and the w.r.t foresets. The pessimistic lower and pessimistic upper approximations of the newly proposed multigranulation rough set model are then investigated for several interesting properties. This article also addresses accuracy measures and measures of roughness. Finally, we give a decision-making algorithm as well as examples from the perspective of application.
PDE-Based 3D Surface Reconstruction from Multi-View 2D Images
Authors: Zhu Zaiping , Iglesias Andres , Zhou Liqi , You Lihua , Zhang Jianjun
Published: February 2022

Partial differential equation (PDE) based surfaces own a lot of advantages, compared to other types of 3D representation. For instance, fewer variables are required to represent the same 3D shape; the position, tangent, and even curvature continuity between PDE surface patches can be naturally maintained when certain conditions are satisfied, and the physics-based nature is also kept. Although some works applied implicit PDEs to 3D surface reconstruction from images, there is little work on exploiting the explicit solutions of PDE to this topic, which is more efficient and accurate. In this paper, we propose a new method to apply the explicit solutions of a fourth-order partial differential equation to surface reconstruction from multi-view images. The method includes two stages: point clouds data are extracted from multi-view images in the first stage, which is followed by PDE-based surface reconstruction from the obtained point clouds data. Our computational experiments show that the reconstructed PDE surfaces exhibit good quality and can recover the ground truth with high accuracy. A comparison between various solutions with different complexity to the fourth-order PDE is also made to demonstrate the power and flexibility of our proposed explicit PDE for surface reconstruction from images.
Acknowledgment to Reviewers of Medicina in 2021
Authors:   Medicina Editorial Office
Published: February 2022

Rigorous peer-reviews are the basis of high-quality academic publishing [...]
Poly(lactic acid)-poly(ethylene glycol)/Magnesium Silicate Membrane for Methylene Blue Removal: Adsorption Behavior, Mechanism, Ionic Strength and Reusability Studies
Authors: Hasanuddin Norilyani Izzati , Mokhtar Wan Nur Aini Wan , Othaman Rizafizah , Anuar Farah Hannan
Published: February 2022

In this work, the effect of magnesium silicate (MgSiO3) as a filler on poly(lactic acid)-poly(ethylene glycol) (PLA-PEG) membrane was investigated towards the enhancement of adsorption capacity for removal of cationic dye. The preparation and fabrication of membranes were performed through copolymerization and phase inversion techniques. Analysis of functional groups, tensile strength, morphology and surface wettability were employed in the characterization of the membranes. After the addition of MgSiO3, it was found that the PLA-PEG/MgSiO3 membrane presented a higher hydrophilic property with improved mechanical strength. Next, the adsorption of methylene blue (MB) was optimized using response surface methodology (RSM) with the parameters mass of membrane and initial concentration of MB solution. The effects of pH and ionic strength were also examined to determine the mechanism involved during adsorption processes, which later were found to be electrostatic interaction and ion-exchange mechanism. From the isotherms and kinetics studies, the PLA-PEG/MgSiO3 membrane was well fitted by the Freundlich model and pseudo second order model, respectively. This membrane also demonstrated reusable character of up to six cycles.
A Neural Network Based Superstructure Optimization Approach to Reverse Osmosis Desalination Plants
Authors: Di Martino Marcello , Avraamidou Styliani , Pistikopoulos Efstratios N.
Published: February 2022

An ever-growing population together with globally depleting water resources pose immense stresses for water supply systems. Desalination technologies can reduce these stresses by generating fresh water from saline water sources. Reverse osmosis (RO), as the industry leading desalination technology, typically involves a complex network of membrane modules that separate unwanted particles from water. The optimal design and operation of these complex RO systems can be computationally expensive. In this work, we present a modeling and optimization strategy for addressing the optimal operation of an industrial-scale RO plant. We employ a feed-forward artificial neural network (ANN) surrogate modeling representation with rectified linear units as activation functions to capture the membrane behavior accurately. Several ANN set-ups and surrogate models are presented and evaluated, based on collected data from the H2Oaks RO desalination plant in South-Central Texas. The developed ANN is then transformed into a mixed-integer linear programming formulation for the purpose of minimizing energy consumption while maximizing water utilization. Trade-offs between the two competing objectives are visualized in a Pareto front, where indirect savings can be uncovered by comparing energy consumption for an array of water recoveries and feed flows.
Enhanced Plasticity and Corrosion Resistance in Mg-Zn-Ca-Cu Amorphous Alloy Composite via Plasma Electrolytic Oxidation Treatment
Authors: Zeng Qingling , Chen Shuangshuang , Song Peidi , Li Haodi , Zeng Xierong
Published: February 2022

In this study, a dendrite-reinforced Mg-based amorphous alloy composite was prepared through an in situ precipitation strategy. After plasma electrolytic oxidation (PEO) treatment, the Mg85.1Zn12.7Ca2Cu0.2 amorphous alloy composite exhibited enhanced plasticity and corrosion resistance in a simulated body fluid solution (SBF). The PEO-treated composite showed a significant plastic strain of 10.5 ± 1.1%, as well as outstanding strain-hardening behavior. The enhancement of plasticity may be attributed to the in-situ formed coating, which can not only serve as a propagation barrier for shear bands but can also introduce nucleation sites in the bands as a result of stress mismatch and compositional heterogeneity. The corrosion density in the SBF decreased by three orders compared with the composite substrate. The spontaneous formation of apatite on the porous layer demonstrated that the prepared PEO coating has high bioactivity. The current work may provide a fundamental basis for developing biomedical Mg-based alloys with excellent comprehensive mechanical properties and corrosion resistance.
The Effect of Bismuth on Technological and Material Characteristics of Low-Alloyed Automotive Steels with a Good Machinability
Authors: Kurka Vladislav , Kuboň Zdeněk , Kander Ladislav , Jonšta Petr , Kotásek Ondřej
Published: February 2022

The aim of this work is to compare the technological and material properties of CMnCr steels without bismuth, with 0.08 wt. % Bi and 0.12 wt. % Bi. Experimental heats showed that the most advantageous alloying of Bi into the heat was in the ladle, with an efficiency of about 20%. The optimal temperature range for forming steel was found to be 1160–1050 °C. With increasing Bi content, the formability of steels and plastic properties decreased, while the yield stress and tensile strength increased. Manganese sulfides, aluminum oxides, or oxysulfides, which were segregated both individually and in clusters, were found in the matrix of all tested steels. In steels with Bi, the Bi particles segregate the separately in the form of globules, either as envelopes of elongated MnS or Al2O3 particles segregated in rows. Sulfur dot-shaped segregations in the steel with 0.12 wt. % of Bi and the steel without Bi were essentially uniform over the whole area. For the steel with 0.08 wt. % of Bi, both dot-like and ray-ordered sulfur segregations were observed. The microstructure of all tested steels was ferritic–pearlitic with islands of bainite. Towards the center of the forged bars, variable shape and size of bainite blocks were observed. Machinability tests evaluated by the extend of tool wear showed that the most advantageous was CMnCr steel alloyed with 0.08 wt. % Bi.
Effect of Iron Ore Pellet Size on Metallurgical Properties
Authors: Iljana Mikko , Paananen Timo , Mattila Olli , Kondrakov Mikhail , Fabritius Timo
Published: February 2022

Iron ore pellets are small and hard spherical particles agglomerated from a fine iron ore concentrate. They are used in the blast furnace process to produce hot metal. The diameter of blast furnace pellets is usually between 8 and 16 mm. In this study, a batch of magnesia iron ore pellets was first sieved into particle sizes of 8–10 mm, 10–12.7 mm, 12.7–16 mm and 16–20 mm, and the four different size fractions were used to study the effect of pellet size on metallurgical properties. The metallurgical experiments showed a decrease both in reducibility under unconstrained conditions and in low-temperature reduction-disintegration but showed an increase in cold crushing strength as the pellet size increased. In the reduction-softening test, pellets sized 10–12.7 mm reached the highest final temperature and the highest reduction degree among the pellet samples of different sizes. Based on the implications drawn from this study, the amount of 10–12.7 mm pellets should be maximized in a blast furnace operation.
Cryoprotective Metabolites Are Sourced from Both External Diet and Internal Macromolecular Reserves during Metabolic Reprogramming for Freeze Tolerance in Drosophilid Fly, Chymomyza costata
Authors: Moos Martin , Korbelová Jaroslava , Štětina Tomáš , Opekar Stanislav , Šimek Petr , Grgac Robert , Koštál Vladimír
Published: February 2022

Many cold-acclimated insects accumulate high concentrations of low molecular weight cryoprotectants (CPs) in order to tolerate low subzero temperatures or internal freezing. The sources from which carbon skeletons for CP biosynthesis are driven, and the metabolic reprogramming linked to cold acclimation, are not sufficiently understood. Here we aim to resolve the metabolism of putative CPs by mapping relative changes in concentration of 56 metabolites and expression of 95 relevant genes as larvae of the drosophilid fly, Chymomyza costata transition from a freeze sensitive to a freeze tolerant phenotype during gradual cold acclimation. We found that C. costata larvae may directly assimilate amino acids proline and glutamate from diet to acquire at least half of their large proline stocks (up to 55 µg per average 2 mg larva). Metabolic conversion of internal glutamine reserves that build up in early diapause may explain the second half of proline accumulation, while the metabolic conversion of ornithine and the degradation of larval collagens and other proteins might be two additional minor sources. Next, we confirm that glycogen reserves represent the major source of glucose units for trehalose synthesis and accumulation (up to 27 µg per larva), while the diet may serve as an additional source. Finally, we suggest that interconversions of phospholipids may release accumulated glycero-phosphocholine (GPC) and -ethanolamine (GPE). Choline is a source of accumulated methylamines: glycine-betaine and sarcosine. The sum of methylamines together with GPE and GPC represents approximately 2 µg per larva. In conclusion, we found that food ingestion may be an important source of carbon skeletons for direct assimilation of, and/or metabolic conversions to, CPs in a diapausing and cold-acclimated insect. So far, the cold-acclimation- linked accumulation of CPs in insects was considered to be sourced mainly from internal macromolecular reserves.
Asparagine Metabolism in Tumors Is Linked to Poor Survival in Females with Colorectal Cancer: A Cohort Study
Authors: Shen Xinyi , Cai Yuping , Lu Lingeng , Huang Huang , Yan Hong , Paty Philip B. , Muca Engjel , Ahuja Nita , Zhang Yawei , Johnson Caroline H. , Khan Sajid A.
Published: February 2022

The interplay between the sex-specific differences in tumor metabolome and colorectal cancer (CRC) prognosis has never been studied and represents an opportunity to improve patient outcomes. This study examines the link between tumor metabolome and prognosis by sex for CRC patients. Using untargeted metabolomics analysis, abundances of 91 metabolites were obtained from primary tumor tissues from 197 patients (N = 95 females, N = 102 males) after surgical colectomy for stage I-III CRC. Cox Proportional hazard (PH) regression models estimated the associations between tumor metabolome and 5-year overall survival (OS) and recurrence-free survival (RFS), and their interactions with sex. Eleven metabolites had significant sex differences in their associations with 5-year OS, and five metabolites for 5-year RFS. The metabolites asparagine and serine had sex interactions for both OS and RFS. Furthermore, in the asparagine synthetase (ASNS)-catalyzed asparagine synthesis pathway, asparagine was associated with substantially poorer OS (HR (95% CI): 6.39 (1.78–22.91)) and RFS (HR (95% CI): 4.36 (1.39–13.68)) for female patients only. Similar prognostic disadvantages in females were seen in lysophospholipid and polyamine synthesis. Unique metabolite profiles indicated that increased asparagine synthesis was associated with poorer prognosis for females only, providing insight into precision medicine for CRC treatment stratified by sex.
Metabolic Features of Saliva in Breast Cancer Patients
Authors: Bel’skaya Lyudmila V. , Sarf Elena A. , Solomatin Denis V. , Kosenok Victor K.
Published: February 2022

The aim of the work was to study the metabolic characteristics of saliva in breast cancer and the subsequent assessment of the potential information content of its individual biochemical indicators. The study included 487 patients of the Omsk Clinical Oncology Center with morphologically verified breast cancer and 298 volunteers without breast pathologies. Saliva samples were obtained from all patients before the start of treatment, and the values of 34 biochemical indicators were determined. It has been shown that concentration of total protein, urea, uric acid (UA), the total content of α-amino acids and lipid peroxidation products, and the activity of metabolic and antioxidant enzymes (in particular catalase—CAT) of saliva changed significantly in breast cancer. Biochemical indicators characterizing early breast cancer have been identified, which can be used for timely diagnosis in addition to existing methods. The coefficients UA/Urea and UA·CAT/Urea are proposed, for which the maximum deviation from the norm was observed in the early stages of the disease. It was shown that for ductal breast cancer, changes in the activity of metabolic enzymes of saliva were more pronounced, while, for lobular breast cancer, the indicators of enzymatic and non-enzymatic components of antioxidant protection changed. The results confirmed the potential importance of saliva in the diagnosis of breast cancer.
Cu2S Nanoflakes Decorated with NiS Nanoneedles for Enhanced Oxygen Evolution Activity
Authors: Wang Le , Li Mancong , Lyu Yingxin , Liu Jiawen , Du Jimin , Kang Dae Joon
Published: February 2022

Metal sulfides are considered excellent materials for oxygen evolution reaction because of their excellent conductivity and high electrocatalytic activity. In this report, the NiS-Cu2S composites were prepared on copper foam (NiS-Cu2S-CF) using a facile synthetic strategy. The scanning electron microscopy results confirmed that the NiS nanoneedles were successfully grown on Cu2S nanoflakes, greatly increasing the active sites. Particularly, the optimized 15% NiS-Cu2S-CF composite demonstrated excellent oxygen evolution activity with a small overpotential of 308 mV@20 mA cm−2, which is significantly smaller than that of noble metal-based electrocatalysts and other NiS-Cu2S-CF composites. The enhanced oxygen evolution activity is attributed to the unique morphology that can provide ample active sites, rich ion-transfer pathways, and the synergistic effect between NiS and Cu2S, which can boost the electron transfer rate.
Theoretical Analysis of Airy–Gauss Bullets Obtained by Means of High Aperture Binary Micro Zonal Plate
Authors: Blaya Salvador , Lopez-Sola Edmundo , Acebal Pablo , Carretero Luis
Published: February 2022

We theoretically analyze the methodology for obtaining vectorial three-dimensional bullets, concretely Airy–Gauss bullets. To do this, binary micro zonal plates (BZP) were designed in order to obtain different Airy–Gauss bullets with sub-diffraction main lobe width. Following the vectorial diffraction theory, among the electrical field, we extend the theory to the magnetic field, and thus we analyze several properties such as the Poynting vector and the energy of Airy–Gauss vectorial bullets generated by illuminating the designed BZP with a temporal Gaussian circular polarized pulses.
Degradation of Decabromodiphenyl Ether in an Aerobic Clay Slurry Microcosm Using a Novel Immobilization Technique
Authors: Hsu Jung-Shan , Yu Ting-Yu , Wei Da-Jiun , Jane Wann-Neng , Chang Yi-Tang
Published: February 2022

A novel chitosan immobilization technique that entraps photocatalyst and microbes was developed and applied to decompose decabromodiphenyl ether (BDE-209) in a clay slurry microcosm. The optimized conditions for immobilization were obtained by mixing 1.2% (w/v) chitosan dissolved in 1% (v/v) acetic acid with nano-TiO2 particles and the BDE-209-degrading bacterial mixed culture. This aqueous mixture was injected into 1% (w/v) water solution containing sodium tripolyphosphate to form spherical immobilized beads. The surface of the immobilized beads was reinforced by 0.25% (v/v) glutaraldehyde cross-linking. These beads had enough mechanical strength during BDE-209 degradation to maintain their shape in the system at a stirring rate of 200-rpm, while undergoing continuous 365 nm UVA irradiation. This novel TiO2-Yi-Li immobilized chitosan beads system allowed a successful simultaneous integration of photolysis, photocatalysis and biodegradation to remove BDE-209. The remaining percentage of BDE-209 was 41% after 70 days of degradation using this system. The dominant bacteria in the BDE-209-degrading bacterial mixed culture during remediation were Chitinophaga spp., Methyloversatilis spp., Terrimonas spp. and Pseudomonas spp. These bacteria tolerated the long-term UVA irradiation and high-level free radicals present, while utilizing BDE-209 as their primary carbon resource. This new method has great potential for the treatment of a range of pollutants.
Evaluating the Application of Rock Breakage without Explosives in Underground Construction—A Critical Review of Chemical Demolition Agents
Authors: Habib Kelly-Meriam , Shnorhokian Shahé , Mitri Hani
Published: February 2022

The method of drilling and blasting with explosives is widely used in rock fragmentation applications in underground construction projects, such as tunnels and caverns. However, the use of explosives is associated with rigorous safety and environmental constraints, since blasting creates toxic fumes, ground vibrations, and dust. Because of these constraints, there has been a growing interest in transitioning away from explosives-based rock fragmentation. The use of explosives-free methods could lead to continuous operation by eliminating the need for idle time with additional ventilation required to exhaust the blast fumes. This paper first presents a critical review of various methods that have been developed so far for rock fragmentation without explosives. Such methods include thermal fragmentation, plasma blasting, controlled foam injection, radial-axial splitter, and supercritical carbon dioxide. Thermal fragmentation, as the name implies, uses high heat to spall high-grade ore. However, it requires high heat energy, which requires additional ventilation as compared to normal conditions to cool the work area. Plasma blasting uses a high temperature and pressure plasma to fracture rock in a safe manner. While this method may be environmentally friendly, its usage may significantly slow tunnel development due to the need to haul one or more large energy capacitor banks into and out of the work area repeatedly. Controlled foam injection is another chemical method, whereby foam is the medium for fracturing. Although claimed to be environmentally friendly, it may still pose safety risks such as air blast or flyrock due to its dynamic nature. A radial-axial splitter (RASP) is an instrument specially designed to fracture a borehole in the rock face but only at the pace of one hole at a time. Supercritical carbon dioxide is used with the equipment designed to provide a high-pressure jet stream to fracture rock, and replaces water in these instruments. The method of soundless chemical demolition agents (SCDA) is evaluated in more detail and its merits over others are highlighted, making it a potentially viable alternative to blasting with explosives in underground excavation applications. Future work involves the optimization of SCDA for implementation in underground mines. The discussion compares the key features and limitations, and future work needs are underlined.
Aquatic Ecological Risk of Heavy-Metal Pollution Associated with Degraded Mining Landscapes of the Southern Africa River Basins: A Review
Authors: Ouma Kennedy , Shane Agabu , Syampungani Stephen
Published: February 2022

Africa accounts for nearly 30% of the discovered world’s mineral reserves, with half of the world’s platinum group metals deposits, 36% of gold, and 20% of cobalt being in Southern Africa (SA). The intensification of heavy-metal production in the SA region has exacerbated negative human and environmental health impacts. In recent years, mining waste generated from industrial and artisanal mining has significantly affected the ecological integrity of SA aquatic ecosystems due to the accelerated introduction and deposition of heavy metals. However, the extent to which heavy-metal pollution associated with mining has impacted the aquatic ecosystems has not been adequately documented, particularly during bioassessments. This review explores the current aquatic ecological impacts on the heavily mined river basins of SA. It also discusses the approaches to assessing the ecological risks, inherent challenges, and potential for developing an integrated ecological risk assessment protocol for aquatic systems in the region. Progress has been made in developing rapid bioassessment schemes (RBS) for SA aquatic ecosystems. Nevertheless, method integration, which also involves heavy-metal pollution monitoring and molecular technology, is necessary to overcome the current challenges of the standardisation of RBS protocols. Citizenry science will also encourage community and stakeholder involvement in sustainable environmental management in SA.
Determination of Thymol in Commercial Formulation, Essential Oils, Traditional, and Ultrasound-Based Extracts of Thymus vulgaris and Origanum vulgare Using a Greener HPTLC Approach
Authors: Foudah Ahmed I. , Shakeel Faiyaz , Alqarni Mohammed H. , Ali Abuzer , Alshehri Sultan , Ghoneim Mohammed M. , Alam Prawez
Published: February 2022

In the literature, greener analytical approaches for determining thymol in its commercial formulations, plant-based phytopharmaceuticals, and biological fluids are scarce. As a result, the goal of this study is to develop and validate a normal-phase “high-performance thin-layer chromatography (HPTLC)” method for determining thymol in commercial formulations, essential oils, traditional extracts (TE), and ultrasound-based extracts (UBE) of Thymus vulgaris and Origanum vulgare obtained from various geographical regions. The greener mobile phase for thymol analysis was a binary combination of cyclohexane and ethyl acetate (85:15, v/v). The derivatized densitometric analysis of thymol was carried out under visible mode at 530 nm utilizing anisaldehyde-sulfuric acid as a derivatizing/visualizing agent. In the 10–2000 ng/band range, the greener normal-phase HPTLC method was linear. Furthermore, for thymol analysis, the proposed analytical approach was simple, quick, inexpensive, accurate, precise, robust, sensitive, and greener. The thymol contents in commercial formulation were computed as 7.61% w/w. In general, the thymol contents were maximum in essential oils of T. vulgaris and O. vulgare compared to the other sample matrices studied. The thymol contents of TE of T. vulgaris and O. vulgare of different geographical regions were significantly low compared to their UBE extract. Using 12 distinct components of green analytical chemistry, the overall “analytical GREEnness (AGREE)” scale for the proposed analytical approach was computed 0.79, showing the good greener nature of the proposed analytical approach. Overall, the greener normal-phase HPTLC technique was found to be reliable for determining thymol in commercial formulations and plant-based phytopharmaceuticals.
Technological and Strength Aspects of Layers Made of Different Powders Laminated on a Polymer Matrix Composite Substrate
Authors: Golewski Przemysław , Sadowski Tomasz
Published: February 2022

This study presents a description of the new technology for producing external or internal layers made of different powders mixed with epoxy resin, which can perform various functions as a protection against impact, erosion, or elevated temperatures as well as provide interlayers during the manufacturing of a ceramic protective barrier by air plasma spraying (APS) on the PMC substrate made of carbon–epoxy. Six types of powders (copper, quartz sand, Al2O3, aluminum, crystalline silica, and microballoon) were used to manufacture (120 °C) different kinds of protective layers (PLs), perfectly joined with the PMCs, in one single autoclave process. The two-layered specimens (2 × 25 × 110 mm) were subjected to a three-point bending (3-PB) displacement-controlled deformation process to determine the critical values of deformations at which the PLs can work safely without being cracked or delaminated. The tests were performed up to the final failure, observing various damage and cracking phenomena. Finally, the numerical simulations were carried out using the representative volume element (RVE) model of the most efforted central parts of the samples to determine the effect of powder grain diameter and resin content on the elastic properties and damage growth of the newly proposed multifunctional PLs. The stress concentrations and damage processes, including cracking and delamination, were analyzed in the whole two-layered system. The best result, in terms of strength during 3-PB testing, was achieved with the PL made of aluminum powder.