bluuebunny/crossref_metadata_2025 huggingface dataset:
First Experience of Standard Linac, Rapid Arc and Dose-drop Scheme Based Total Body Irradiation
Authors: Xu Zhiyuan , Yang Li , Hui Tim , Jiang Xiaoqin , chan Jeff , Cheung Jacob , Wang Qian , Lee Eric , Zhou Cheng , Cai Linbo , Chen Longhua
Published: November 2020

Background and purpose: To introduce a standard linac with true attachment free, rapid arc and dose-drop scheme for positioning related dose deviation control based total body irradiation(TBI).Materials/Methods: One eight years old girl diagnosed with acute lymphocytic leukemia underwent TBI in 2020. Target volumes and organs at risk were contoured after CT simulation. Total sixteen ARC and four AP-PA from five isocenters were designed. A dose-drop scheme on both sides of adjacent region were performed to reduce positioning-related dose deviation. A series of quality assurance before radiotherapy and real-time dose monitoring during radiotherapy were carried out.Results: The average on board imaging (OBI) time of per fraction was 40.3 min, the average beam on time of per fraction was 37.2 min, the average time to change from head first to feet first position was 18.4 min. The average mean lung dose was 9.89 Gy, the maximum lens dose was 7.60 Gy, the mean PTV_total dose was 12.17Gy, 98.23% PTV_total volume was covered by 90% of the prescription dose. The maximum dose (Dmax) of PTV_total was 13.65Gy. Dmean and V10.8 of PTV_total are only slightly different(0.49% - 1.89% and 0.26% - 1.04% respectively) even with an error of 5 - 20mm longitudinal misalignments. Gamma passing rate(3mm/ 3% Gamma criteria) are between 93.5% and 100%. Real-time dose monitoring showed an overall deviation of -3.9%±5.51%.Conclusions: Standard linac, rapid arc and dose-drop for positioning-related dose deviation control based total body irradiation is feasible, accurate, and reliable. It is worthy of clinical application.
Estimation of Polycyclic Aromatic Hydrocarbons pollution, risk assessment and loads into Mediterranean Sea from Volturno River, Southern Italy.
Authors: Montuori Paolo , Rosa Elvira De , Duca Fabiana Di , Provvisiero Donatella Paola , Sarnacchiaro Pasquale , Nardone Antonio , Triassi Maria
Published: November 2020

Background: This study reports the data on the contamination caused by polycyclic aromatic hydrocarbons (PAHs) drained into the Volturno River and its environmental impact on the Tyrrhenian Sea (Central Mediterranean Sea). One of the key aims of this study is to use the PAHs as indicators of pollution, by identifying the main sources from which these pollutants originate. Also, the ecosystem health risk and the seasonal and spatial distribution of PAHs in samples of water and sediment was assessed. The 16 PAHs identified by the USEPA as priority pollutants were determined in the water dissolved phase, suspended particulate matter and sediments collected from 10 sites in four seasons.Results: A multidimensional statistical approach was used to identify three pollution composite indicators. Contaminant discharges of PAHs into the sea were calculated in about 3.158,2 kg/year showing that this river should account as one of the main contribution sources of PAHs to the Tyrrhenian Sea. Total concentrations of PAHs varied in ranges 434.8 to 872.1 ng g-1 and 256.7 to 1686.3 ng L-1 in sediment samples and in water (total of water dissolved phase and suspended particulate matter), respectively. Conclusion: The statistical results indicated that the PAHs mainly had a pyrolytic source and the rainy season was the most polluted time. The toxic equivalent concentration (TEQ) of carcinogenic PAHs was 130.3 to 302.1 ngTEQ g-1, implying that the Volturno River basin presents a definite carcinogenic risk.
Paclitaxel Resistance in Ovarian Cancers Relies on a PGAM1 Mediated Glycolytic Metabolism
Authors: Feng Yan , Zhang Xu , Zhang Songfa , Xu Shanshan , Chen Xiaojing , Zhou Caiyun , Wang Xinyu , Xie Xing , Lu Weiguo
Published: November 2020

Background: Paclitaxel, as an anti-microtubule drug, has been recommended to be the first-line chemotherapy agent for ovarian cancer for about two decades. However, most patients with advanced stage relapse within two years and ultimately die of relapsed cancer displaying increased chemoresistance. The mechanisms underlying paclitaxel resistance remain ncompletely understood.Methods: The paclitaxel-resistant ovarian cancer cell line SKOV3-TR30 and its parental cell line SKOV3 were analyzed by proteinomics. The glycolytic enzyme PGAM1-modulated glycolytic flux including pyruvic acid production and lactic acid production, and mitochondrial function was investigated using the assays kit. The correlations between PGAM1 expression, overall survival and progression free survival were evaluated for ovarian cancer patients. To elucidate the underlying mechanisms involved in paclitaxel resistance, PGAM1 gene knockout, gene overexpression and/or manipulation of glycolytic products were employed, followed by Western blot, immunostaining, and cell viability assay.Results: PGAM1 was highly expressed in the paclitaxel resistant ovarian cancer cell line SKOV3-TR30, as compared to its parental cell line SKOV3. A high expression of PGAM1 was ignificantly correlated with a reduced overall survival and progression free survival in ovarian cancer patients. Under paclitaxel exposure, SKOV3 cells showed a stronger mitochondrial function than SKOV3-TR30 cells, suggesting that under the stress, SKOV3-TR30 cells had responded with enhanced glycolysis rather than undergoing oxidative phosphorylation. Down-regulation of PGAM1 in SKOV3 TR30 cells resulted in decreased paclitaxel resistance. Up-regulation of PGAM1 in SKOV3 cells led to enhanced paclitaxel resistance. Analysis of the lycolytic flux revealed that PGAM1-mediated pyruvic acid or lactic acid production could control the capabilities of ovarian cancer cell resistance to paclitaxel.Conclusions: Our study demonstrated that PGAM1 could act as a modulator linked to paclitaxel sensitivity in ovarian cancer cells. Blocking PGAM1 may provide a new approach to reverse paclitaxel resistance in ovarian cancer patients.
The Psychological Responses and Associated Factors of Chinese College Students During COVID-19 Outbreak in February
Authors: Zhang Xu-dong , Jing Hui-quan , Wang Yang , Li Kun-hang , Zhao Dan , Yu Hong-ye , Zhang Lu-yang , Wang Wei , Liu Yan , Song Yue-qun , Zhang Feng , Xu Ming-lu , Sun Xiao-wei , Bao Yi-jun
Published: November 2020

BackgroundThe novel coronavirus pneumonia (COVID-19) is a highly contagious and highly pathogenic disease caused by a novel coronavirus（SARS-CoV-2）and has become pandemic within a short period of time. The epidemic has brought not only the risk of death from infection but also unbearable psychological pressure. College students as a special group, their mental health status need to be studied during the outbreak of COVID-19.MethodsWe used the Self-Rating Anxiety Scale (SAS), Self-Rating Depression Scale (SDS), and the compulsive behavior part of the Yale-Brown Obsessive-Compulsive Scale (YBOCS), combined with demographic information, using online questionnaires to research, and the study was conducted between February 21 and 24, 2020. A total of 2270 valid questionnaires were collected, the respondents of these questionnaires included 563 medical students and 1707 non-medical students. We separately analyzed the mental health status of medical and non-medical students during the outbreak of COVID-19.ResultsOf the 563 medical students, 20 (3.55%) students had anxiety symptoms, and 57 (10.12%) students had depressive symptoms. Gender, PMH, compulsive behavior, and regularity of daily life during the epidemic outbreak were correlated with their anxiety symptoms and age, PMH, compulsive behavior, and regularity of daily life during the epidemic outbreak were associated with their depressive symptoms. Of the 1707 non-medical students, 66 (3.87%) students had anxiety symptoms, and 180 (10.54%) students had depressive symptoms. Gender, contact history of similar infectious disease, PMH, compulsive behavior, regularity of daily life and exercise during the epidemic outbreak and concern on COVID-19 were correlated with their anxiety symptoms and contact history of similar infectious disease, PMH, compulsive behavior, regularity of daily life and exercise during the epidemic outbreak and concern on COVID-19 were associated with their depressive symptoms.ConclusionsResults indicated that gender, age, contact history of similar infectious disease, past medical history (PMH), compulsive behavior, regularity of daily life, and exercise during the epidemic outbreak are the key factors making college students anxious or depressed. The results provided a theoretical basis for relevant interventions; it is also essential for medical education and public health epidemic prevention.
Genome-Wide Analysis of Spatiotemporal Expression Patterns During Rice Leaf Development
Authors: Miya Masayuki , Yoshikawa Takanori , Sato Yutaka , Itoh Jun-Ichi
Published: November 2020

Background: Rice leaves consist of three distinct regions along a proximal-distal axis, namely the leaf blade, sheath, and blade-sheath boundary region. Each region has a unique morphology and function, but the genetic programs underlying the development of each region are poorly understood. To fully elucidate rice leaf development and discover genes with unique functions in rice and grasses, it is crucial to explore genome-wide transcriptional profiles during the development of the three regions.Results: In this study, we performed microarray analysis to profile the spatial and temporal patterns of gene expression in the rice leaf using dissected parts of leaves sampled in broad developmental stages. The dynamics in each region revealed that the transcriptomes changed dramatically throughout the progress of tissue differentiation, and those of the leaf blade and sheath differed greatly at the mature stage. Cluster analysis of expression patterns among leaf parts revealed groups of genes that may be involved in specific biological processes related to rice leaf development. Moreover, we found novel genes potentially involved in rice leaf development using a combination of transcriptome data and in situ hybridization, and analyzed their spatial expression patterns at high resolution. We successfully identified multiple genes that exhibit localized expression in tissues characteristic of rice or grass leaves.Conclusions: Although the genetic mechanisms of leaf development have been elucidated in several eudicots, direct application of that information to rice and grasses is not appropriate due to the morphological and developmental differences between them. Our analysis provides not only insights into the development of rice leaves but also expression profiles that serve as a valuable resource for gene discovery. The genes and gene clusters identified in this study may facilitate future research on the unique developmental mechanisms of rice leaves.
Ferritin is associated with the severity of lung involvement but not with worse prognosis in patients with COVID-19: data from two Italian COVID-19 Units.
Authors: Carubbi Francesco , Salvati Lia , Alunno Alessia , Maggi Fabio , Borghi Erika , Mariani Rinalda , Mai Francesca , Paoloni Maurizio , Ferri Claudio , Desideri Giovambattista , Cicogna Sabrina , Grassi Davide
Published: November 2020

The coronavirus 2019 disease (COVID-19) is characterised by a heterogeneous clinical presentation, a complex pathophysiology and a wide range of imaging ﬁndings, depending on disease severity and time course. We conducted a retrospective evaluation of hospitalized patients with proven SARS-CoV-2 infection, clinical signs of COVID-19 and computed tomography (CT) scan-proven pulmonary involvement, in order to identify relationships between clinical, serological, imaging data and disease outcomes in patients with COVID-19. Clinical and serological records of patients admitted to two COVID-19 Units of the Abruzzo region in Italy with proven SARS-CoV-2 pulmonary involvement investigated with CT scan, assessed at the time of admission to the hospital, were retrospectively evaluated.Sixty-one patients (22 females and 39 males) of median age 65 years were enrolled. Fifty-six patients were discharged while death occurred in 5 patients. None of the lung abnormalities detected by CT was different between discharged and deceased patients. No differences were observed in the features and extent of pulmonary involvement according to age and gender. Logistic regression analysis with age and gender as covariates demonstrated that ferritin levels over the 25th percentile were associated with the involvement of all 5 pulmonary lobes (OR=14.5, 95% CI=2.3-90.9, p=0.004), the presence of septal thickening (OR=8.2, 95% CI=1.6-40.9, p=0.011) and the presence of mediastinal lymph node enlargement (OR=12.0, 95% CI=1.1-127.5, p=0.039) independently of age and gender.We demonstrated that ferritin levels over the 25th percentile are associated with a more severe pulmonary involvement, independently of age and gender and not associated with disease outcomes. The identification of reliable biomarkers in patients with COVID-19 may help guiding clinical decision, tailoring therapeutic approaches and ultimately improving the care and prognosis of patients with this disease.
Care Burden and Coping Strategies Among Caregivers of Paediatric HIV/AIDS in Northern Uganda: A Cross-sectional Mixed-method Study
Authors: Mujjuzi Ibrahim , Mutegeki Paul , Nabuwufu Sarah , Wosukira Ashim , Namata Fazirah , Alayo Patience , Amanya Sharon Bright , Nyeko Richard
Published: November 2020

Background: Family caregivers provide the bulk of care to children living with HIV. This places an enormous demand and care burden on the caregivers, who often struggle to cope in various ways, some of which may be maladaptive. This may adversely affect their quality of care. Very few literatures exist in resource-limited contexts on the burden of care experienced by caregivers on who children living with HIV/AIDS depend for their long term care. We assessed care burden and coping strategies among the caregivers of paediatric HIV/AIDS patients in Lira district, northern Uganda. Methods: A mixed-methods cross-sectional study was conducted among 113 caregivers of paediatric HIV patients attending ART clinic at a tertiary healthcare facility in Lira district, northern Uganda. Consecutive sampling method was used to select participants for the quantitative study, while 15 respondents were purposively sampled for the qualitative data. Quantitative data were collected using standard interviewer-administered questionnaires while in-depth interview guides were used to collect qualitative data. Data were entered, cleaned, and analysed using SPSS version 23. Qualitative data were analysed thematically. Results: Majority of the caregivers 65.5% (74) experienced mild to moderate burden. The mean burden scores significantly differed by caregivers’ age ( P =0.017), marital status ( P =0.017), average monthly income ( P =0.035) and the child’s school attendance ( P =0.039). Accepting social support, seeking spiritual support and reframing were the three most commonly used strategies for coping. Marital status and occupation were respectively positively and negatively correlated with information seeking as a coping strategy, while monthly income was positively correlated with psychosocial support as a strategy. Seeking community support was negatively correlated with the duration of the child's care. Conclusions: Our findings show that care burden is a common problem among the caregivers of children living with HIV in the study context.
Electroencephalogram Dynamics of Etomidate-Induced Loss of Consciousness
Authors: Gu Erwei , Zhang Lei , Fan Shunqin , Zhang Jiawei , Fang Kun , Wang Lei , Cao Yuanyuan , Chen Lijian , Liu Xuesheng
Published: November 2020

BackgroundHighly structured electroencephalography (EEG) oscillations can occur in adults during etomidate-induced general anesthesia, but the link between these two phenomena is poorly understood. Therefore, in the present study, we investigated the relationship between the neurological mechanism of etomidate-induced loss of consciousness (LOC) and electroencephalogram dynamics of etomidate-induced loss of consciousness.MethodsEtomidate-induced anesthesia was performed on eligible patients undergoing elective surgery. We analyzed EEG data from 20 patients who received etomidate for the induction of general anesthesia. We used power spectra and coherence methods to process and analyze the EEG data.ResultsCompared with the baseline (awake period), etomidate induced an increase in power in each band during loss of consciousness. Compared with the awake period, the delta-wave (1–4 Hz) coherence increased significantly during loss of consciousness, while the slow-wave (<1Hz) coherence decreased.ConclusionsThe neural circuit mechanism of etomidate-induced loss of consciousness is closely related to the induction of oscillation in each EEG band and is closely related to the enhancement of delta-wave, alpha-wave, and theta-wave coherence.Trial registration﻿ChiCTR1800017110.
Regional Anesthesia For Postdural Puncture Headache (PDPH): A New Solution For An Old Problem? A Systemic Review.
Authors: Giaccari Luca Gregorio , Coppolino Francesco , Aurilio Caterina , Esposito Valentina , Pace Maria Caterina , Passavanti Maria Beatrice , Pota Vincenzo , Sansone Pasquale
Published: November 2020

Background: Postdural puncture headache (PDPH) is one of the earliest recognized complications of regional anesthesia. It is a common complication after inadvertent dural puncture. When conservative management is ineffective, the Epidural Blood Patch (EBP) is the “gold standard” for the treatment of PDPH. Due to the potential complications of EBP, several alternatives have been promoted as peripheral nerve blocks.A systematic review of the use of regional anesthesia for PDPH is needed to identify an alternative method of pain management.Objectives: To systematically review literature to establish the efficacy and applicability of regional anesthesia used in the treatment of PDPH in the hospital setting.Methods: Embase, MEDLINE, Google Scholar and Cochrane Central Trials Register were systematically searched in May 2020 for studies examining regional anesthesia for PDPH. The methodological quality of the studies and their results were appraised using the Consensus-based Standards for the Selection of Health Measurement Instruments (COSMIN) checklist and specific measurement properties criteria, respectively.Results: Nineteen studies evaluating peripheral nerve blocks for PDPH were included for a total of 221 patients. Sphenopalatine ganglion block (SPGB), greater occipital nerve block (GONB) and lesser occipital nerve block (LONB) were performed. All participants reported NRS lower than 4 after peripheral nerve blocks at 1, 24 and 48 hours. Only patients who experienced PDPH after diagnostic lumbar puncture reported NRS ≥ 4 after 48 hours. No adverse event was reported after the execution of nerve blocks, except an occasionally discomfort related to the insertion of cotton-tip applicators intranasally for SPGB. 17% of patients underwent a second or more peripheral nerve block due to uncontrolled pain. In 30 participants, EBP was required; none of cases followed spinal anesthesia.Conclusion: Peripheral nerve blocks can be considered as analgesic options in the management of PDPH, as not all cases require EBP for successful treatment. Treatment of PDPH with peripheral nerve blocks seems to be a minimal invasive, easy and effective method, which can offer to patients when conservative management is ineffective.
Assessing the Usability of Complex Psychosocial Interventions: The Intervention Usability Scale
Authors: Lyon Aaron R , Pullmann Michael D. , Jacobson Jedediah , Osterhage Katie , Achkar Morhaf Al , Renn Brenna N. , Munson Sean A. , Areán Patricia A.
Published: November 2020

Background. Usability – the extent to which an intervention can be used by specified users to achieve specified goals with effectiveness, efficiency, and satisfaction – is a key determinant of implementation success. However, few instruments have been developed to measure the design quality of complex health interventions (i.e., those with several interacting components). This study evaluated the structural validity of the Intervention Usability Scale (IUS), an adapted version of the well-established System Usability Scale (SUS) for digital technologies, to measure the usability of a leading complex psychosocial intervention, Motivational Interviewing (MI), for behavioral health service delivery in primary care. Prior SUS studies have found both one- and two-factor solutions, both of which were examined in the current study of the IUS.Method. A survey administered to 136 medical professionals from 11 primary care sites collected demographic information and IUS ratings for MI, the evidence-based psychosocial intervention that primary care providers reported using most often for behavioral health service delivery. Factor analyses replicated procedures used in prior research on the SUS.Results. Analyses indicated that a two-factor solution (with “usable” and “learnable” subscales) best fit the data, accounting for 54.1% of the variance. Inter-item reliabilities for the total score, usable subscale, and learnable subscale were α = .83, α = .84, and α = .67, respectively.Conclusions. This study provides evidence for a two-factor IUS structure consistent with some prior research, as well as acceptable reliability. Implications for implementation research evaluating the usability of complex health interventions are discussed, including the potential for future comparisons across multiple interventions and provider types, as well as the use of the IUS to evaluate the relationship between usability and implementation outcomes such as feasibility.
Systemic immune-inflammation index predicts prognosis of sequential therapy with sorafenib and regorafenib in hepatocellular carcinoma
Authors: Hong Young Mi , Yoon Ki Tae , Cho Mong
Published: November 2020

Background: Regorafenib has shown promising results as a second-line therapy for patients with hepatocellular carcinoma (HCC) who progressed on sorafenib. Although several data regarding the efficacy of sequential therapy with sorafenib and that of regorafenib in real-life, specific inflammation markers for predicting the prognosis have not been studied. This study aimed to investigate prognostic value of systemic inflammatory markers in patients with HCC who received sorafenib-regorafenib sequential therapy. Methods: We retrospectively analyzed medical data of patients who received regorafenib for the treatment of HCC after sorafenib failure. Progression free survival (PFS) and overall survival (OS) were assessed using the Kaplan–Meier survival curves. Univariate and multivariate analyses were performed to analyze the factors associated with survival.Results: A total of 58 patients who received at least one dose of regroafenib and fulfilled the eligibility criteria, good performance status (Eastern Cooperative Oncology Group [ECOG] 0-1) and preserved liver function (Child-Pugh-A), were included in the analysis. The median PFS was 3 months (95% confidence interval [CI] = 0.981-5.019) and the median OS was 8 months (95% CI=5.761–10.239). Elevated systemic immune-inflammation index (SII ≥340) was independently associated with poor OS. In multivariate analysis, the SII (hazard ratio [HR] = 2.211, 95% CI = 1.089-4.489, P = 0.028) and alpha-fetoprotein (AFP) (HR = 2.750, 95% CI = 1.259-6.010, P = 0.011) were independent predictors of OS.Conclusion: Elevated SII is associated with poor OS in patients with HCC who received sequential therapy with sorafenib and regorafenib. In addition, when selecting a treatment strategy, the SII can be used in combination with the AFP level as a promising prognostic tool for HCC.
Assessment of mortality in correlation with comorbidities in COVID-19 patients of Telangana state.
Authors: Mesipogu Rajarao , Adeula Vinayasekhar , Bingi Thrilok Chander , Kammili Nagamani , Manolla Madhavilatha , Maurya Akhilesh Kumar , Kalakuntla Hemanth , Rao Krothapalli Tushara , Vyshnavi Jamalapuram , Thomas Winnie , Sudarsi Ravindra Kumar , I Shyamsundar Raju , Vanamala Shivaprasad , Pandharpurkar Deepak , Billa Seshadri
Published: November 2020

Background The mortality data of COVID cases around the world has less explored in relation to comorbidities.The dogma/question to be answered is that the virus perse resulting or any comorbidities contributing to such frightened deaths.The aim of the study is to describe the clinical and epidemiological characteristics of 201 deceased from Telangana. We retrospectively collected all consecutive death cases with laboratory‐confirmed COVID‐19 infection admitted from March to mid-June at Gandhi Hospital the nodal centre designated for COVID-19 in Telangana. Clinical history, comorbidities, laboratory findings and treatment were recorded for each patient.Results A total of 15394 patients with confirmed COVID‐19 test were admitted at Isolation wards between March 2020 and June 2020 and 253 death cases were reported till the submission of this paper. The mean age of death is 57.0 ys in our study, 40.7% (88) deaths were above 60 years and 71.4% (147) were male. Several comorbid conditions existed with COVID-19 death cases among which hypertension being the most common comorbidity (60.1%). Lymphopenia was observed in 46% cases while lymphopenia with comorbidity was recorded in 63% cases.Conclusion In this retrospective study, most of the COVID‐19 deceased patients were elderly male aged with an age range from 50-60 yrs and above. Mortality rate and severity are higher in males than females. Our study indicated the importance of understanding comorbid conditions in COVID‐19 cases especially Hypertension and Diabetes mellitus as they were more likely succumb to death.
Polarization-transparent silicon photonic add-drop multiplexer with wideband hitless tuneability
Authors: Morichetti Francesco , Milanizadeh Maziyar , Petrini Matteo , Zanetto Francesco , Ferrari Giorgio , Aguiar Douglas Oliveira de , Guglielmi Emanuele , Sampietro Marco , Melloni Andrea
Published: November 2020

Flexible optical networks require reconfigurable devices with operation on a wavelength range of several tens of nanometers, hitless tuneability (i.e. transparency to other channels during reconfiguration), and polarization independence. All these requirements have not been achieved yet in a single photonic integrated device and this is the reason why the potential of integrated photonics is still largely unexploited in the nodes of optical communication networks. Here we report on a fully-reconfigurable add-drop silicon photonic filter, which can be tuned well beyond the extended C-band (almost 100 nm) in a complete hitless (>35 dB channel isolation) and polarization transparent (1.2 dB polarization dependent loss) way. This achievement is the result of blended strategies applied to the design, calibration, tuning and control of the device. Transmission quality assessment on dual polarization 100 Gbit/s (QPSK) and 200 Gbit/s (16-QAM) signals demonstrate the suitability for dynamic bandwidth allocation in core networks, back-haul networks, intra- and inter-datacenter interconnects.
× Pseudorhiza nieschalkii (Senghas) P.F.Hunt nothosubsp. siculorum H.Kertész & N.Anghelescu, 2020 A Intergeneric Orchid Hybrid New to Science
Authors: Angelli) Nora Anghelescu (aka Nora De , KERTÉSZ Hajnalka , Constantin Nicoleta , SIMON-GRUIȚA Alexandra , CORNESCU Gerogiana DUȚĂ , POJOGA Maria D. , Georgescu Mihaela , Petra Sorina , Toma Florin
Published: November 2020

We describe the ﬁrst reported intergeneric hybrid to naturally occur between two subspecies belonging to different genera, Dactylorhiza fuchsii subsp. sooana (genus Dactylorhiza) and Pseudorchis albida subsp. tricuspis (genus Pseudorchis), as × Pseudorhiza nieschalkii (Senghas) P.F.Hunt nothosubsp. siculorum H.Kertész & N.Anghelescu, 2020. The hybrid was found and digitally photographed for the first time by Hajnalka Kertész in June, 2020, within Terra Siculorum, in one of the Natura 2000 protected areas, known as Harghita Mădăraș, ROSCI00090. Following detailed morphometric analysis using 67 characters and molecular karyological analyses, we identified this unique specimen as an intergeneric hybrid, new to science. The hybrid, an F1 generation plant, most likely representing a single intergeneric pollination event, is phenotypically intermediate between its parental species in most of the characters scored, but it significantly closely resembles Pseudorchis albida subsp. tricuspis parent. Since the parental species occurred in near proximity (1-10 meters distance), we suggest that the production of this hybrid required a minimum travel distance of ca 1-10 meters, by the pollinators and frequent exchange of pollen between the parental species was very likely.
Two-Effects-in-One: Kinetic Quantum and Molecular Sieving Effect in a Robust-Flexible [Th6Co2] Cage for both Isotope and Isomer Separation
Authors: Yin Mengjia , Krishna Rajamani , Wang Wenjing , Yuan Daqiang , Fan Yaling , Feng Xuefeng , Wang Li , Luo Feng
Published: November 2020

Although molecular and quantum sieving (MS and QS) effects have been realized and employed to execute separation tasks, however, little is known about the coexistence of both effects in a compound and its corresponding structure. In this work, we show the first observation of coexistence of both quantum and molecular sieving effects in a [Th6Co2] cage-based compound (Th-Co-Cage-1). The [Th6Co2] cage shows 0.78 nm aperture but with an irregular crescent-like window. This allows [Th6Co2] cage to give ultrahigh uptake for hydrogen isotope and selectivity towards D2 over H2, leading to complete hydrogen isotope separation, as evidenced by experimental breakthrough test. When the size of guest molecule is more than the crescent-like window, a highly rare robust-flexible adsorption was observed, consequently leading to complete isomer separation for C4 and C6 isomers through molecular sieving effect. High thermal, water and chemical stability further supports the materials for practical separation application. The results open up a gate of material with coexistence of QS and MS effects and its fundamental design for superior separation application.
Genome-Wide association study identifies new elements on the genetic basis of quality-related traits in wheat across multiple environments
Authors: Pu Zhien , Ye Xueling , Li Yang , Liu Zehou , Shi Bingxin , Dai Shoufen , Jiang Yunfeng , Li Wei , Jiang Qiantao , Chen Guoyue , Wei Yuming , Zheng Youliang
Published: November 2020

Backgrounds: Grain protein concentration (GPC), grain starch concentration (GSC), and wet gluten concentration (WGC) are complex traits that determine nutrient concentration, end-use quality, and yield in wheat. To identify the elite and stable loci or genomic regions conferring high GPC, GSC, and WGC, a genome-wide association study (GWAS) based on a mixed linear model (MLM) was performed using 55K single nucleotide polymorphism (SNP) array in a panel of 236 wheat accessions, including 160 commercial varieties and 76 landraces, derived from Sichuan Province, China. The panel was evaluated for GPC, GSC, and WGC at four different fields. Results: Phenotypic analysis showed variation in GPC, GSC, and WGC among the different genotypes and environments. GWAS identified 12 quantitative trait loci (QTL) (-log10(P) > 2.5) associated with these three quality traits in at least two environments and located on chromosomes 1B, 1D, 2A, 2B, 2D, 3B, 3D, 5D, and 7D; the phenotypic variation explained (PVE) by these QTL ranged from 4.2% to 10.7%. Among these, three, seven, and two QTL are associated with GPC, GSC, and WGC, respectively; five QTL (QGsc.sicau-1BL, QGsc.sicau-1DS, QGsc.sicau-2DL.1, QGsc.sicau-2DL.2, QWgc.sicau-5DL) were defined potentially novel Compared with the previously reported QTLs/genes by linkage or association mapping, 5 QTLs (QGsc.sicau-1BL, QGsc.sicau-1DS, QGsc.sicau-2DL.1, QGsc.sicau-2DL.2, QWgc.sicau-5DL) were potentially novel. Furthermore, 21 presumptive candidate genes, which are involved in the metabolism or transportation of all kinds of carbohydrates, photosynthesis, programmed cell death, the balance of abscisic acid and ethylene, within these potentially novel genomic regions were predicted. Conclusions: This study provided new genetic resources and valuable genetic information of nutritional quality to broaden the genetic background and laid the molecular foundation for marker-assisted selection in wheat quality breeding.
Scientific Research In The Health Tourism Market: A Systematic Literature Review
Authors: Letunovska N. , Kwilinski A. , Kaminska B.
Published: November 2020

The authors pay attention to bibliographic analysis in the field of health tourism. The primary purpose of the study is to find out which countries’ works predominate in scientific circles, and which nationalities have the most significant influence in the scientific community in terms of the number and content of their research. In particular, they do an in-depth analysis of researches in health tourism marketing. The authors put forward hypotheses about the growing popularity of marketing research in this category, which they confirmed during their investigation. Besides, the study concluded that most articles in health tourism marketing are analytical, systematizing data from secondary sources. The authors constructed a visualized representation of the relationships of important concepts, namely the services market, tourism market, health, and medical tourism. The total number of articles and cited articles in the authoritative world scientometric databases Scopus and Web of Science have been performed. TOP authors and countries that make the most considerable contribution to the number of studies of the selected category are selected. The main keywords used in articles on health tourism are systematized, among which it is possible to single out a cluster of purely marketing concepts. The authors constructed a PRISMA chart to cut off less relevant articles and select those related to the marketing aspects of the health services market. The inferences made it possible to form a detailed classification of health tourism by identifying key categories and the role of components of the tourist offer in them. The author’s research will be useful for further research in health tourism, as it provides a basis for some of the works already analyzed and describes the tools for bibliographic analysis of literature sources.

Keywords: health tourism market, marketing in health tourism, medical tourism, preventive tourism, PRISMA diagram.
On kinetics of impurity extraction from iron concentrate obtained by rough copper concentrate hydrometallurgical processing
Authors:   KazHydroMed LLP, Karimova Lyutsiya , Khazhimukhametov Tagir ,   KazHydroMed LLP, Kairalapov Yerlan ,   KazHydroMed LLP, Yun Alexander ,   KazHydroMed LLP
Published: November 2020

The purpose of the paper is to study the physical and chemical features of high-quality iron concentrate precipitation from nitric acid leaching solutions of low-grade copper-sulfide raw materials, and to obtain a highly profitable product which is suitable for direct processing at ferrous metallurgy enterprises. To conduct the experiments on obtaining impurity rich and depleted iron concentrate a hydrolytic precipitate containing 54.6% iron and numerous impurities obtained as a result of processing of nitric acid leaching solutions of rough copper sulfide concentrate from the Zhezkazgan deposit is used. Analytical studies of initial materials and resulting products of the processes under investigation are conducted using the modern certified methods including the x-ray spectral, x-ray phase, atomic absorption analysis, mass spectrometry method with inductively coupled plasma. We have obtained a high-quality iron concentrate containing minimal amounts of silicon, aluminum, phosphorus and sulfur as well as partial and generalized equations that give an idea of the influence of the studied factors on the indicators of the iron concentrate production process. The apparent activation energy of the process has been calculated - 46.77 kJ/mol. It probably indicates the presence of diffusion complications caused by the formation of solid products passivating the surface of the material being dissolved. The principal possibility of obtaining high-quality iron concentrate from processing poor copper-sulfide concentrate middlings of the Zhezkazgan deposit is shown. The mathematical processing of experimental data has resulted in the determination of equations that characterize the degree of influence of the studied factors on the process indicators. It is found out that the production process of the saleable iron concentrate proceeds in the mode of diffusion restrictions. It is the first time, when multivariate generalized dependencies are obtained for the process under consideration and their analytical transformations are performed. These methods can be used to study the analogous processing of similar metallurgical raw materials.
On efficiency of digital system of power transformer proactive diagnostics
Authors:   Vologda State University, Alyunov Alexander , Vyatkina Olga ,   Vologda State University, Nemirovskiy Alexander ,   Vologda State University
Published: November 2020

The purpose of the paper is to diagnose the state of a power transformer by determining its equivalent circuit parameters by means of synchronized vector measurements of currents and voltages in the transformer normal operation mode without shutdowns, which makes it possible to increase the reliability of relay protection operation. A cost - effective method for proactive diagnostics of power transformers is proposed. Through monitoring of additional parameters (short circuit resistance, active and inductive resistance of the positive sequence, active and inductive resistance of the negative sequence) it can increase the speed and accuracy of detecting possible internal short circuits arising due to winding damage or high-voltage transformer bushings without diagnosed transformer disconnection from the network. The method allows to estimate the transformer health index and serviceability by the difference between the calculated parameters of the equivalent circuit and the passport values of the parameters. Having conducted the damage causedependent analysis of the number of power transformer damages, the authors determined total economic losses that include the losses caused by equipment damage and losses caused by the interruptions in consumer power supply. The total economic losses for a power transformer with a rated power of 63 MVA amounted to 10687402 rubles. It is shown that the diagnostic system expands the possibilities of analyzing the transformer state in operating modes, allows to pr event the approaching of the damage moment and occurrence of sudden accidents as well as minimizes the expected damage from shutdowns and equipment failure. A hardware and software complex is proposed for the diagnostics of power transformer internal damage. The given main characteristics of the proposed hardware and software complex include the number of measuring channels, accuracy class, sampling frequency, and others. The results of the work expand the possibilities of analyzing the transformer state in the operating mode and can be used in the world practice of creating various monitoring systems designed to identify the defects developing in transformers caused by winding deformation.
Spatial Models for Identifying Factors in Student Academic Achievement
Authors: AKBAŞ-YEŞİLYURT Filiz , KOÇAK Hüseyin , YEŞİLYURT Muhammet Ensar
Published: November 2020

In the literature, estimation results of the determinants of academic achievement are controversial. There may be several reasons for these controversial results, including sample or cultural differences. Conversely, these results may arise from ignoring certain important facts, such as an interaction effect. Some studies do not consider interactions among students, and some studies may not use effective models. Surprisingly, very few studies have focused on student academic achievement using spatial models, which may be one of the most suitable models for testing interaction effects. In this study, we estimated student achievement using spatial models and a data sets from Turkey. We observed an interaction between students who live in the same neighbourhood and found evidence of an interaction among students in terms of their achievement based on a spatial error model.
Neugodni i novi sadržaji u funkciji kreativnosti: Po čemu se studenti umjetnosti razlikuju od ostalih?
Authors:   Fakultet dramskih umetnosti, Univerzitet umetnosti u Beogradu, Beograd, Srbija, Ristić Irena J. , Milošević Miloš ,   Fakultet dramskih umetnosti, Univerzitet umetnosti u Beogradu, Beograd, Srbija
Published: November 2020

Dosadašnja istraživanja djelomično potvrđuju psihodinamske pretpostavke da neugodni i novi sadržaji mogu poticajno djelovati na kreativnost. Upitno je, međutim, na koji način bliskost sadržaja, pojedine dimenzije emocionalnog doživljaja, i kvalitete emocija djeluju na produkciju izrazito kreativnih osoba i pokazuju li oni izvjesne specifičnosti tijekom generativnih procesa. U ovom istraživanju ispituje se stupanj i vrsta povezanosti između kreativnosti odgovora i kvalitete emocija (radosti, žalosti, straha, srdžbe, iznenađenja i gađenja), dimenzija emocionalnog doživljaja (valencije i uzbuđenosti) i bliskosti sadržaja kod različitih studentskih populacija. Eksperiment je izveden uz sudjelovanje 59 studenata, a za vizualnu stimulaciju je izabrano 40 fotografija, tako da su vrijednosti dimenzija i kvalitete emocionalnog doživljaja sustavno varirane. Od ispitanika je traženo da ocijene koliko im je blizak sadržaj fotografija, a zatim da smisle najkreativniji naslov za svaku od njih. Kreativnost naslova je mjerena putem koeficijenata kreativnosti i izuzetnosti baziranih na statističkoj procjeni originalnosti. Rezultati potvrđuju umjerenu negativnu povezanost kreativnosti s valencijom, s bliskošću sadržaja i s radošću, zatim umjerenu pozitivnu povezanost kreativnosti s uzbuđenošću, žalošću, strahom, srdžbom, iznenađenjem i gađenjem, kao i specifičnosti kreativnog procesa studenata umjetnosti, kod kojih novina i iznenađenje preuzimaju primat pred drugim dimenzijama i kvalitetama emocionalnog doživljaja. Ključne riječi: kreativnost, primarne emocije, bliskost sadržaja, dimenzije emocionalnog doživljaja, umjetnička produkcija
Upitnik emocionalne kompetentnosti za djecu (UEK-D) – Preliminarni rezultati prilagodbe i validacije
Authors:   Filozofski fakultet, Sveučilište u Rijeci, Rijeka, Stupin Mia , Mohorić Tamara ,   Filozofski fakultet, Sveučilište u Rijeci, Rijeka, Ilijašić Veršić Ivana
Published: November 2020

Upitnik emocionalne kompetentnosti (UEK-45, Takšić, 1998, 2002) temelji se na hijerarhijskom modelu emocionalne inteligencije (EI), koji EI definira kao sposobnost percepcije i izražavanja emocija, integracije emocija u procese mišljenja, razumijevanja emocija te sposobnost upravljanja emocijama. Do sada je korišten u velikom broju istraživanja i preveden na više od 10 svjetskih jezika, međutim, ne postoji prilagođena i provjerena verzija upitnika koja bi bila primjerena djeci osnovnoškolske dobi. S obzirom na važnost istraživanja emocionalnih aspekata dječjeg razvoja, nužno je imati provjerene mjere na temelju kojih se mogu donositi valjani zaključci. Ovo je istraživanje prvi korak u prilagodbi Upitnika emocionalne kompetentnosti za djecu. U istraživanju je sudjelovao 171 ispitanik, učenici viših razreda osnovne škole, u dobi od 11 do 15 godina te 277 ispitanika 5. i 6. razreda, iz osnovnih škola iz Rijeke i Rovinja. Upitnik emocionalne kompetentnosti za djecu zadržao je originalnu trofaktorsku strukturu uz dobru sadržajnu valjanost i pouzdanost (koja je jedino nešto niža za podljestvicu Regulacije i upravljanja emocijama). Dobivene su očekivane umjerene korelacije s osobinama ličnosti iz modela velikih pet. Što se tiče kriterijske valjanosti, emocionalna kompetentnost značajno je povezana s altruističnim ponašanjem te sa školskim uspjehom (iako vrlo nisko), a nije dobivena povezanost s agresivnim ponašanjem iako se prema dosadašnjim istraživanjima ona očekuje. Upitnik je jezično i brojem čestica prilagođen djeci. U daljnjim istraživanjima potrebno je sadržajno prilagoditi upitnik kako bi se obuhvatilo što više aspekata emocionalne inteligencije te dodatno provjeriti strukturu upitnika. Ključne riječi: emocionalna kompetentnost, UEK-D, rana adolescencija, osobine ličnosti velikih pet
Procrastination: Relations with Mood, Self-Efficacy, Perceived Control and Task Demands
Authors:   Faculty of Humanities and Social Sciences, University of Mostar, Mostar, BIH, Šuvak-Martinović Marijana , Čarapina Zovko Ivona ,   Faculty of Humanities and Social Sciences, University of Mostar, Mostar, BIH
Published: November 2020

Procrastination is widely recognized as a motivational problem, but its nature is still not entirely understood, especially in the work domain. Procrastination in the execution of everyday work tasks could be motivated by both mood repair and predictor of poor mood. It could also be related to task characteristics, like averseness or demands. The aim of this study is to examine the relation between procrastination, levels of self-efficacy, perceived job demands and control, and symptoms of anxiety and depression. This study was conducted on a sample of 70 teaching assistants, the employees of a small university. The data was collected using Avoidance reactions to a deadline scale, DASS, Self-efficacy scale and Job demand-control scale. Correlation results indicated that self-efficacy and perceived job control were negatively, and job demand positively related to proneness to procrastination. Furthermore, individuals with more symptoms of anxiety and depression tended to procrastinate more. Perceived job control is the single relevant predictor of delaying job-related tasks and activities. The findings clearly suggest that job control deserves additional attention when it comes to the prediction of workplace procrastination. Keywords: procrastination, job control, job demands, self-efficacy, affect
Osnivanje i djelatnost stanice za savjetovanje pri izboru zvanja od 1931. do 1948. godine – početak primijenjene psihologije u Hrvatskoj
Authors:   Institut društvenih znanosti Ivo Pilar, Zagreb, Žebec Šilj Ivana , Žebec Mislav Stjepan ,   Fakultet hrvatskih studija, Sveučilište u Zagrebu, Zagreb
Published: November 2020

Stanica za savjetovanje pri izboru zvanja osnovana je 19. lipnja 1931. odlukom Izvršnog odbora Zavoda za unapređivanje obrta Komore za trgovinu, obrt i industriju u Zagrebu. Glavna joj je zadaća bila savjetovanje mladih pri izboru obrtničkih ili trgovačkih zanimanja kao i pri izboru stručne škole, a na osnovi liječničkog pregleda tjelesne razvijenosti i zdravlja te psihologijskog testiranja sposobnosti i sklonosti. Osnutak Stanice za savjetovanje pri izboru zvanja može se smatrati početkom razvoja primijenjene psihologije u Hrvatskoj. Tijekom 17 godina djelovanja Stanicu (kasnije preimenovanu u Zavod) posjetilo je preko 30.000, a psihološki je testirano oko 20.000 osoba. Iako se posljednjih godina djelovanja Stanice/Zavoda broj ispitanih drastično povećao, Zavod je ugašen, dok je psihotehnika (prevladavajuća djelatnost Zavoda) izbačena iz nastavnog programa Psihološkog instituta Sveučilišta u Zagrebu. Ključne riječi: Trgovinsko-industrijska komora, Stanica za savjetovanje pri izboru zvanja, Zavod za savjetovanje u izboru zvanja, Zavod za psihologiju i fiziologiju rada, psihotehnika (primijenjena psihologija), Hrvatski Radiša