bluuebunny/crossref_metadata_2025 huggingface dataset:
Timing, Mechanics and Controls of the Evolution of the Southernmost Part of the Oman Mountains: The Salakh Arch
Authors: Al-Kindi Mohammed H. N.
Published: March 2020

Regional surface and subsurface mapping of the front range of the Oman Mountains, Salakh Arch’s fold-and-thrust belt, is conducted to understand the timing and nature of its deformation and to analyze the main controls on its position, geometry and evolution. The results from this study can be applied to other fold-and-thrust belts, as the area offers surface and subsurface datasets that allow good understanding of its evolution history. The deformation of the outcropping Middle Miocene to Pliocene deposits and the displacement of the Cenozoic seismic reflections imply that folding and thrusting was active during the Neogene and possibly ceased during the Early Quaternary. The palaeostress-tensor analyses from the kinematic fault data along with the fold-axes trends show that the regional transport direction was, overall, directed to the south. Lateral movements over oblique or lateral ramps, between the frontal ramps, have caused local deflections of the regional stress trajectories. The shortening values measured from restored seismic sections were utilized to restore the arch in map view. The restoration indicates that the arch initiated as a primary arc right from the start of deformation. As the shortening proceeded, clockwise and anticlockwise rotations occurred in some areas as a consequence of displacement gradients across adjacent areas along the arch. This rotation was most likely accommodated by angular shear strain, which results in arch-parallel extension or transtension. Various factors have controlled the position, geometry and segmentation of the fold segments in the Salakh Arch. The folds that developed in areas of thicker deformed sediments are wider and more uplifted and advanced to the foreland than the folds that develop in thin deformed sediments. Pre-existing faults were reactivated as lateral and frontal ramps during the arch’s evolution. They have contributed in the location and segmentation of the fold patches. On the other hand, the depth-to-detachment measurements and restoration results suggest that the folds detach along the Ediacaran-Early Cambrian Ara Salt. Overall, the deformation in the Salakh Arch could be described as an interaction between thin- and thick-skinned tectonics.
Evaluating Spatial Scenarios for Sustainable Development in Quito, Ecuador
Authors: Salazar Esthela , Henríquez Cristián , Sliuzas Richard , Qüense Jorge
Published: March 2020

Peripheral urban sprawl configures new, extensive conurbations that transcend current administrative boundaries. Land use planning, supported by the analysis of future scenarios, is a guide to achieve sustainability in large metropolitan areas. To understand how urban sprawl is consuming natural and agricultural land, this paper analyzes land use changes in the metropolis of Quito, considering a combination of urban planning, natural conservation and risk areas. Using the Dyna-CLUE model we simulate spatial demands for future land uses by 2050, based on two growth scenarios: the trend scenario (unrestricted growth) and the regulated scenario, which considers two parameters—a government proposal for urban expansion areas and laws that protect natural areas. Both scenarios show how urban expansion consumes agricultural and natural areas. This expansion is backed by urban policies which do not sufficiently account for conservation areas nor for risk areas. Therefore, these simulations suggest that planning should follow a more holistic approach that explicitly considers urban growth beyond current administrative limits, in what we refer to as the New Metropolitan Area of Quito.
Cartographic Symbology for Crisis Mapping: A Comparative Study
Authors: Kuveždić Divjak Ana , Đapo Almin , Pribičević Boško
Published: March 2020

Cartographic symbols on crisis maps serve as means of depicting information about the position, properties, and/or numerical values of objects, phenomena or actions specific to crisis mapping. Many crisis cartographic visualisations require simple, clear, categorised and visually organised symbols that can be easily read and understood by a wide range of crisis map users. Cartographic symbol sets for crisis mapping depend on effective graphic design, good availability (sharing and promotion, dissemination and promulgation) and standardisation (ensuring the general and repeatable use of map symbols). In this research, our aim was to examine the extent of these challenges in current cartographic symbology for crisis mapping. Through a comparative study of prominent symbol sets, we analysed efforts invested so far and proposed future directions. The results of this study may be of assistance in understanding less unified or coherent symbologies currently in use, or in revising or amplifying existing sets for future publication.
A Review of Geospatial Semantic Information Modeling and Elicitation Approaches
Authors: Kokla Margarita , Guilbert Eric
Published: March 2020

The present paper provides a review of two research topics that are central to geospatial semantics: information modeling and elicitation. The first topic deals with the development of ontologies at different levels of generality and formality, tailored to various needs and uses. The second topic involves a set of processes that aim to draw out latent knowledge from unstructured or semi-structured content: semantic-based extraction, enrichment, search, and analysis. These processes focus on eliciting a structured representation of information in various forms such as: semantic metadata, links to ontology concepts, a collection of topics, etc. The paper reviews the progress made over the last five years in these two very active areas of research. It discusses the problems and the challenges faced, highlights the types of semantic information formalized and extracted, as well as the methodologies and tools used, and identifies directions for future research.
Design of a 3D Platform for Immersive Neurocognitive Rehabilitation
Authors: Avola Danilo , Cinque Luigi , Pannone Daniele
Published: March 2020

In recent years, advancements in human–computer interaction (HCI) have enabled the development of versatile immersive devices, including Head-Mounted Displays (HMDs). These devices are usually used for entertainment activities as video-gaming or augmented/virtual reality applications for tourist or learning purposes. Actually, HMDs, together with the design of ad-hoc exercises, can also be used to support rehabilitation tasks, including neurocognitive rehabilitation due to strokes, traumatic brain injuries, or brain surgeries. In this paper, a tool for immersive neurocognitive rehabilitation is presented. The tool allows therapists to create and set 3D rooms to simulate home environments in which patients can perform tasks of their everyday life (e.g., find a key, set a table, do numerical exercises). The tool allows therapists to implement the different exercises on the basis of a random mechanism by which different parameters (e.g., objects position, task complexity) can change over time, thus stimulating the problem-solving skills of patients. The latter aspect plays a key role in neurocognitive rehabilitation. Experiments obtained on 35 real patients and comparative evaluations, conducted by five therapists, of the proposed tool with respect to the traditional neurocognitive rehabilitation methods highlight remarkable results in terms of motivation, acceptance, and usability as well as recovery of lost skills.
Null Models for Formal Contexts
Authors: Felde Maximilian , Hanika Tom , Stumme Gerd
Published: March 2020

Null model generation for formal contexts is an important task in the realm of formal concept analysis. These random models are in particular useful for, but not limited to, comparing the performance of algorithms. Nonetheless, a thorough investigation of how to generate null models for formal contexts is absent. Thus we suggest a novel approach using Dirichlet distributions. We recollect and analyze the classical coin-toss model, recapitulate some of its shortcomings and examine its stochastic properties. Building upon this we propose a model which is capable of generating random formal contexts as well as null models for a given input context. Through an experimental evaluation we show that our approach is a significant improvement with respect to the variety of contexts generated. Furthermore, we demonstrate the applicability of our null models with respect to real world datasets.
Robust Beamforming Design for SWIPT-Based Multi-Radio Wireless Mesh Network with Cooperative Jamming
Authors: Li Liang , Zhao Xiongwen , Geng Suiyan , Zhang Yu , Zhang Lei
Published: March 2020

Wireless mesh networks (WMNs) can provide flexible wireless connections in a smart city, internet of things (IoT), and device-to-device (D2D) communications. The performance of WMNs can be greatly enhanced by adopting a multi-radio technique, which enables a node to communicate with more nodes simultaneously. However, multi-radio WMNs face two main challenges, namely, energy consumption and physical layer secrecy. In this paper, both simultaneous wireless information and power transfer (SWIPT) and cooperative jamming technologies were adopted to overcome these two problems. We designed the SWIPT and cooperative jamming scheme, minimizing the total transmission power by properly selecting beamforming vectors of the WMN nodes and jammer to satisfy the individual signal-to-interference-plus-noise ratio (SINR) and energy harvesting (EH) constrains. Especially, we considered the channel estimate error caused by the imperfect channel state information. The SINR of eavesdropper (Eve) was suppressed to protect the secrecy of WMN nodes. Due to the fractional form, the problem was proved to be non-convex. We developed a tractable algorithm by transforming it into a convex one, utilizing semi-definite programming (SDP) relaxation and S-procedure methods. The simulation results validated the effectiveness of the proposed algorithm compared with the non-robust design.
The Dynamic Evolution Mechanism of Heterogeneous OWOM—An Improved Viral Marketing Model
Authors: Liao Mengjie , Qi Lin , Zhang Jian
Published: March 2020

The negative impact of brand negative online word-of-mouth (OWOM) on social images in social media is far greater than the promotion of positive OWOM. Thus, how to optimize brand image by improving the positive OWOM effect and slowing the negative OWOM communication has turned into an urgent problem for brand enterprises. On this basis, we analyze the evolution process of the OWOM communication group of the social media brand network based on the SOR (stimulus-organism-response) theory of psychology. Through constructing the heterogeneous brand OWOM communication dynamic model and conducting the multi-agent-based simulation experiment, the dynamic visualization of brand OWOM communication effect combined the thinking model of viral marketing is realized. Experiments show that the ability of brand communicators to persuade has a direct impact on the persistence and breadth of brand communication. When the acceptance of the consumer market is high, the negative OWOM of the brand has a relatively huge impact on consumers.
Cool Down–Warm Up: Differential Responses of Stored Product Insects after Gradual Temperature Changes
Authors: Athanassiou Christos G. , Arthur Frank H.
Published: March 2020

Insect survival after exposure to 0 °C for 7 days was examined in laboratory bioassays for control of adults of six major stored-product beetle species, Oryzaephilus surinamensis (L.), the sawtoothed grain beetle, Cryptolestes ferrugineus, (Stephens), the rusty grain beetle, Dermestes maculatus DeGeer, the hide beetle, Sitophilus oryzae (L.), the rice weevil, Tribolium castaneum (Herbst), the red flour beetle, and T. confusum Jacquelin DuVal, the confused flour beetle In this test there were four different acclimation treatments, insects that had been subjected to a pre-acclimation period to 0 °C, a post-acclimation period, both a pre and post-acclimation period, and adults that were not acclimated. Insect survival for all species except S. oryzae was not affected by the exposure to 0 °C, regardless of the acclimation scenario. In contrast, exposure to 0 °C drastically reduced survival of S. oryzae. Moreover, adults that were exposed to the post-acclimation only and un-acclimated adults had lower survival rates than those that had either exposure to pre-acclimation, or to both pre- and post-acclimation. Results of this experiment show that acclimation played a limited role in adult survival of five of the six tested species, and that exposure of adults to 0 °C for 7 d had no effect in survival of these species as well.
Effects of Non-Lethal High-Temperature Stress on Bradysia odoriphaga (Diptera: Sciaridae) Larval Development and Offspring
Authors: Shi Caihua , Zhang Seng , Hu Jingrong , Zhang Youjun
Published: March 2020

Throughout China, the dipteran pest Bradysia odoriphaga significantly reduces Chinese chive production; therefore, identifying conditions that influence its growth and development is crucial for developing ecological regulation strategies. In this study, different non-lethal high temperatures and treatment durations were used to stress the third-instar larvae of B. odoriphaga, and the effects of this treatment on their growth and offspring were recorded and analyzed. The results showed that the average larval mortality increased with increased temperature and prolonged exposure times. After stress treatment at 40 °C for 2 h, 100% of larvae died within 5 days, which was not significantly different from the 5-day average larval mortality (90.66%) after stress at 37 °C for 4 h, but significantly higher than the 5-day average larval mortality (72.00%) after stress at 40 °C for 1 h. After 5 days, all still-living larvae could pupate, and there was no significant difference in average pupal period after pupation. However, the eclosion rate of subsequent pupae decreased with increased temperature and prolonged exposure times, and were only 43.00% and 42.73% after larvae were stressed at 37 °C for 4 h and 40 °C for 1 h, respectively. After eclosion into adults, there was no significant difference in the lifespan of unmated female adults, while the lifespan of unmated male adults was significantly reduced to 1.67 d and 2 d after larvae were stressed at 37 °C for 4 h and 40 °C for 1 h, respectively. However, there was no significant difference in male and female adult longevity after mating. There was no significant difference in oviposition or egg hatchability. This indicates that non-lethal high temperature at 37 °C for 4 h can hinder development and allow control of B. odoriphaga. There is great potential for non-lethal high temperature to be applied in the field to control agricultural pests.
Urine E-cadherin: A Marker for Early Detection of Kidney Injury in Diabetic Patients
Authors: Koziolek Michael , Mueller Gerhard A. , Dihazi Gry H. , Jung Klaus , Altubar Constanze , Wallbach Manuel , Markovic Ivana , Raddatz Dirk , Jahn Olaf , Karaköse Hülya , Lenz Christof , Urlaub Henning , Dihazi Abdelhi , El Meziane Abdellatif El , Dihazi Hassan
Published: March 2020

Diabetic nephropathy (DN) is the main reason for end-stage renal disease. Microalbuminuria as the non-invasive available diagnosis marker lacks specificity and gives high false positive rates. To identify and validate biomarkers for DN, we used in the present study urine samples from four patient groups: diabetes without nephropathy, diabetes with microalbuminuria, diabetes with macroalbuminuria and proteinuria without diabetes. For the longitudinal validation, we recruited 563 diabetic patients and collected 1363 urine samples with the clinical data during a follow-up of 6 years. Comparative urinary proteomics identified four proteins Apolipoprotein A-I (APOA1), Beta-2-microglobulin (B2M), E-cadherin (CDH1) and Lithostathine-1-alpha (REG1A), which differentiated with high statistical strength (p < 0.05) between DN patients and the other groups. Label-free mass spectrometric quantification of the candidates confirmed the discriminatory value of E-cadherin and Lithostathine-1-alpha (p < 0.05). Immunological validation highlighted E-cadherin as the only marker able to differentiate significantly between the different DN stages with an area under the curve (AUC) of 0.85 (95%-CI: [0.72, 0.97]). The analysis of the samples from the longitudinal study confirmed the prognostic value of E-cadherin, the critical increase in urinary E-cadherin level was measured 20 ± 12.5 months before the onset of microalbuminuria and correlated significantly (p < 0.05) with the glomerular filtration rate measured by estimated glomerular filtration rate (eGFR).
Factors Affecting Total Treatment Time in Patients Treated with Orthognathic Surgery Using the Surgery-First Approach: Multivariable Analysis Using 3D CT and Scanned Dental Casts
Authors: Kim Jun-Young , Park Jin Hoo , Jung Hwi-Dong , Jung Young-Soo
Published: March 2020

The aim of this study was to analyze factors affecting treatment times in patients treated with the surgery-first approach (SFA) for orthognathic surgery. Fifty skeletal class III patients who had undergone SFA bimaxillary orthognathic surgery were enrolled. Retrospective chart reviews and analysis of 3D CT and digitally scanned casts were conducted to assess the total treatment time. Statistical analysis was then performed with multiple study variables. Longer treatment times were required for patients with severe maxillary or mandibular teeth crowding (p = 0.009), a preoperative anterior open bite (p = 0.021), and those undergoing orthodontic extractions (p < 0.001). Longer treatment times were also observed when setting surgical occlusion in the postoperative anterior open bite (p = 0.007) and in patients with postoperative dental midline deviation (p < 0.001) and transverse maxillary deficiencies (p = 0.035). Treatment times were shorter when a class I molar key was formed in the surgical occlusion setup (p = 0.002) and in bilateral anterior and posterior occlusion with a minimum of four contact points (p < 0.001). The number of contact points, the number of extracted teeth, and postoperative midline deviation were identified as significant predictors. These results suggest that proper patient selection is important when considering SFA and that surgeons can reduce total treatment time with an appropriate surgical occlusion setup.
Do Chronic Obstructive Pulmonary Diseases (COPD) Self-Management Interventions Consider Health Literacy and Patient Activation? A Systematic Review
Authors: Yadav Uday Narayan , Lloyd Jane , Hosseinzadeh Hassan , Baral Kedar Prasad , Harris Mark Fort
Published: March 2020

Self-management (SM) includes activities that patients initiate and perform in the interest of controlling their disease and maintaining good health and well-being. This review examines the health literacy and patient activation elements of self-management interventions for Chronic Obstructive Pulmonary Diseases (COPD) patients. We investigated the effects of the intervention on health-related quality of life, self-efficacy, depression, and anxiety among people with COPD. We conducted a systematic review of studies evaluating the efficacy of self-management interventions among COPD patients that also included health literacy or patient activation as keywords. Four electronic databases Medline, EMBASE, PsycINFO, and Google Scholar, were searched to identify eligible studies. These studies were screened against predetermined inclusion criteria. Data were extracted according to the review questions. Twenty-seven studies met the criteria for inclusion. All of the included studies incorporated health literacy components and focused on COPD and self-management skills. Three studies measured health literacy; two showed improvements in disease knowledge, and one reported a significant change in health-related behaviors. Seventeen studies aimed to build and measured self-efficacy, but none measured patient activation. Eleven studies with multicomponent interventions showed an improvement in quality of life. Six studies that focused on specific behavioral changes with frequent counseling and monitoring demonstrated improvement in self-efficacy. Two interventions that used psychosocial counseling and patient empowerment methods showed improvement in anxiety and depression. Most self-management interventions did not measure health literacy or patient activation as an outcome. Successful interventions were multicomponent and comprehensive in addressing self-management. There is a need to evaluate the impact of comprehensive self-management interventions that address and measure both health literacy and patient activation on health outcomes for COPD patients.
A Method for the Prediction of Clinical Outcome Using Diffusion Magnetic Resonance Imaging: Application on Parkinson’s Disease
Authors: Tsai Chih-Chien , Lin Yu-Chun , Ng Shu-Hang , Chen Yao-Liang , Cheng Jur-Shan , Lu Chin-Song , Weng Yi-Hsin , Lin Sung-Han , Chen Po-Yuan , Wu Yi-Ming , Wang Jiun-Jie
Published: March 2020

Robust early prediction of clinical outcomes in Parkinson’s disease (PD) is paramount for implementing appropriate management interventions. We propose a method that uses the baseline MRI, measuring diffusion parameters from multiple parcellated brain regions, to predict the 2-year clinical outcome in Parkinson’s disease. Diffusion tensor imaging was obtained from 82 patients (males/females = 45/37, mean age: 60.9 ± 7.3 years, baseline and after 23.7 ± 0.7 months) using a 3T MR scanner, which was normalized and parcellated according to the Automated Anatomical Labelling template. All patients were diagnosed with probable Parkinson’s disease by the National Institute of Neurological Disorders and Stroke criteria. Clinical outcome was graded using disease severity (Unified Parkinson’s Disease Rating Scale and Modified Hoehn and Yahr staging), drug administration (levodopa equivalent daily dose), and quality of life (39-item PD Questionnaire). Selection and regularization of diffusion parameters, the mean diffusivity and fractional anisotropy, were performed using least absolute shrinkage and selection operator (LASSO) between baseline diffusion index and clinical outcome over 2 years. Identified features were entered into a stepwise multivariate regression model, followed by a leave-one-out/5-fold cross validation and additional blind validation using an independent dataset. The predicted Unified Parkinson’s Disease Rating Scale for each individual was consistent with the observed values at blind validation (adjusted R2 0.76) by using 13 features, such as mean diffusivity in lingual, nodule lobule of cerebellum vermis and fractional anisotropy in rolandic operculum, and quadrangular lobule of cerebellum. We conclude that baseline diffusion MRI is potentially capable of predicting 2-year clinical outcomes in patients with Parkinson’s disease on an individual basis.
Backcalculating the Incidence of Infection with COVID-19 on the Diamond Princess
Authors: Nishiura Hiroshi
Published: March 2020

To understand the time-dependent risk of infection on a cruise ship, the Diamond Princess, I estimated the incidence of infection with novel coronavirus (COVID-19). The epidemic curve of a total of 199 confirmed cases was drawn, classifying individuals into passengers with and without close contact and crew members. A backcalculation method was employed to estimate the incidence of infection. The peak time of infection was seen for the time period from 2 to 4 February 2020, and the incidence has abruptly declined afterwards. The estimated number of new infections among passengers without close contact was very small from 5 February on which a movement restriction policy was imposed. Without the intervention from 5 February, it was predicted that the cumulative incidence with and without close contact would have been as large as 1373 (95% CI: 570, 2176) and 766 (95% CI: 587, 946) cases, respectively, while these were kept to be 102 and 47 cases, respectively. Based on an analysis of illness onset data on board, the risk of infection among passengers without close contact was considered to be very limited. Movement restriction greatly reduced the number of infections from 5 February onwards.
Implications of Hemostasis Disorders in Patients with Critical Limb Ischemia—An In-Depth Comparison of Selected Factors
Authors: Wieczór Radosław , Kulwas Arleta , Rość Danuta
Published: March 2020

Background: Atherosclerosis is a systemic disease. Among patients with atherosclerosis, those suffering from peripheral arterial disease (PAD) represent a group of individuals with particularly high death risk, especially during the course of critical limb ischemia (CLI). In the pathogenesis of PAD/CLI complications, blood coagulation disorders play a significant role. The study aim was to examine the activation of the coagulation system depending on tissue factor (TF) in patients with CLI as compared with those with intermittent claudication (IC). Methods: Before initiating proper treatment (invasive or maintenance), blood samples were collected from 65 patients with CLI and 15 with IC to measure the following selected hemostasis parameters: concentrations and activation of tissue factor (TF Ag and TF Act) and tissue factor pathway inhibitor (TFPI Ag and TFPI Act), concentrations of thrombin–antithrombin complex (TAT Ag) and fibrinogen, platelet count (PLT), and concentrations of tissue-plasminogen activator (t-PA Ag), plasminogen activator inhibitor 1 (PAI-1), and D-dimer. The control group included 30 healthy volunteers (10 female/20 male). Results: The values of all analyzed parameters (except for lower TFPI Act) were significantly higher in the blood of PAD patients (with respect to PLT only in the CLI subgroup) in comparison with healthy subjects. The blood of patients with CLI as compared to the IC subgroup revealed much higher concentrations of TF Ag (p < 0.001), with slightly decreased TF Act, significantly lower concentrations of TFPI Ag (p < 0.001), slightly increased TFPI Act, and significantly higher levels of TAT Ag (p < 0.001), fibrinogen (p = 0.026), and D-dimer (p < 0.05). Conclusions: In patients with CLI, we can observe coagulation activation and a shifting balance toward prothrombotic processes. Furthermore, increased concentrations of D-dimer suggest a secondary activation of fibrinolysis and confirm the phenomenon as a prothrombotic condition with heightened fibrinolysis.
Current and Future Aspects of Multimodal Imaging, Diagnostic, and Treatment Strategies in Bicuspid Aortic Valve and Associated Aortopathies
Authors: Afzal Shazia , Piayda Kerstin , Maier Oliver , Goh Shouheng , Hellhammer Katharina , Cramer Mareike , Bönner Florian , Polzin Amin , Nijhof Niels , Kelm Malte , Zeus Tobias , Veulemans Verena
Published: March 2020

Bicuspid aortic valve (BAV) is the most frequent congenital cardiac abnormality leading to premature aortic valve apparatus dysfunction and is often associated with aortopathy. Therefore, current guidelines recommend a surgical aortic valve replacement (SAVR), even if many patients are deemed inoperable owing to their comorbidities and require alternatives such as transcatheter aortic valve replacement (TAVR). However, BAV variations remain challenging for procedural success. Therefore, the latest development in different imaging modalities (echocardiography, multislice-computertomographie, cardiovascular magnetic resonance) allows in-depth analysis for preprocedural risk stratification, follow up, and patient selection. Furthermore, we shed light on the latest developments in pre- and periprocedural fusion imaging as well as on current and future treatment options.
Invasive Assessment of the Myocardial Microcirculation during Beating Heart Coronary Artery Bypass Grafting
Authors: Hellmann Marcin , Piotrowski Jakub , Kaszubowski Mariusz , Dudziak Maria , Anisimowicz Lech
Published: March 2020

Coronary artery bypass grafting may be associated with several cardiac complications, including ischemia, acute myocardial infarction, arrhythmias, or hemodynamic instability. Accumulating evidence suggests that well-developed coronary collateral circulation may protect against adverse effects, including myocardial ischemia. Assessment of myocardial microvascular perfusion is, therefore, of great clinical interest in beating heart surgery. In this paper, myocardial microvascular perfusion is continuously assessed on the beating heart using laser Doppler flowmetry in consecutive patients who underwent coronary artery bypass grafting procedures. No significant (p = 0.110) differences were found between the averaged perfusion signal (n = 42) at the baseline, during artery occlusion, or after reperfusion (732.4 ± 148.0 vs. 711.4 ± 144.1 vs. 737.0 ± 141.2, respectively). In contrast, significantly different (p < 0.001) mean perfusion signals (n = 12) were found (805.4 ± 200.1 vs. 577.2 ± 212.8 vs. 649.3 ± 220.8) in a subset of patients who presented with hemodynamic instability and myocardial ischemia. Additionally, a strong positive correlation between the plasma levels of high-sensitivity troponin I and perfusion decrease level after artery occlusion was found (r = 0.854, p < 0.001). This study argues that myocardial microvascular perfusion remains constant during coronary artery bypass grafting on the beating heart in advanced coronary artery disease. This phenomenon is most likely due to an extensive coronary collateral circulation.
Immunotherapy against Systemic Fungal Infections Based on Monoclonal Antibodies
Authors: Boniche Camila , Rossi Suélen Andreia , Kischkel Brenda , Vieira Barbalho Filipe , Nogueira D’Aurea Moura Ágata , Nosanchuk Joshua D. , Travassos Luiz R. , Pelleschi Taborda Carlos
Published: March 2020

The increasing incidence in systemic fungal infections in humans has increased focus for the development of fungal vaccines and use of monoclonal antibodies. Invasive mycoses are generally difficult to treat, as most occur in vulnerable individuals, with compromised innate and adaptive immune responses. Mortality rates in the setting of our current antifungal drugs remain excessively high. Moreover, systemic mycoses require prolonged durations of antifungal treatment and side effects frequently occur, particularly drug-induced liver and/or kidney injury. The use of monoclonal antibodies with or without concomitant administration of antifungal drugs emerges as a potentially efficient treatment modality to improve outcomes and reduce chemotherapy toxicities. In this review, we focus on the use of monoclonal antibodies with experimental evidence on the reduction of fungal burden and prolongation of survival in in vivo disease models. Presently, there are no licensed monoclonal antibodies for use in the treatment of systemic mycoses, although the potential of such a vaccine is very high as indicated by the substantial promising results from several experimental models.
Promotion of Healthy Nutrition and Physical Activity Lifestyles for Teenagers: A Systematic Literature Review of The Current Methodologies
Authors: Villasana María Vanessa , Pires Ivan Miguel , Sá Juliana , Garcia Nuno M. , Zdravevski Eftim , Chorbev Ivan , Lameski Petre , Flórez-Revuelta Francisco
Published: March 2020

Amid obesity problems in the young population and apparent trends of spending a significant amount of time in a stationary position, promoting healthy nutrition and physical activities to teenagers is becoming increasingly important. It can rely on different methodologies, including a paper diary and mobile applications. However, the widespread use of mobile applications by teenagers suggests that they could be a more suitable tool for this purpose. This paper reviews the methodologies for promoting physical activities to healthy teenagers explored in different studies, excluding the analysis of different diseases. We found only nine studies working with teenagers and mobile applications to promote active lifestyles, including the focus on nutrition and physical activity. Studies report using different techniques to captivate the teenagers, including questionnaires and gamification techniques. We identified the common features used in different studies, which are: paper diary, diet diary, exercise diary, notifications, diet plan, physical activity registration, gamification, smoking cessation, pictures, game, and SMS, among others.
Virtual Reality Treatment for Public Speaking Anxiety in Students. Advancements and Results in Personalized Medicine
Authors: Hinojo-Lucena Francisco-Javier , Aznar-Díaz Inmaculada , Cáceres-Reche María-Pilar , Trujillo-Torres Juan-Manuel , Romero-Rodríguez José-María
Published: March 2020

Public speaking anxiety (PSA) is a common phobia in the student population. Traditionally, exposure therapy has been used as a treatment. However, the use of virtual reality (VR) is increasingly common to treat PSA. The purpose of this paper was to analyze the published scientific literature on VR as a treatment for PSA in students. The articles indexed in two databases (Web of Science and Scopus) were analyzed, with a time period from the beginning of the first publications until 2019 included. The systematic literature review was based on fixed inclusion and exclusion criteria. A total of 13 studies were identified which included 481 students. The results collected indicate that the duration of treatments to have positive effects was at least one week, where the number of sessions was between one and twelve. Furthermore, most VR treatments reported positive effects. Finally, this study showed evidence that VR treatment for PSA is effective while being less invasive than in vivo exposure.
Optimization of Cutting Data and Tool Inclination Angles During Hard Milling with CBN Tools, Based on Force Predictions and Surface Roughness Measurements
Authors: Matras Andrzej , Zębala Wojciech
Published: March 2020

This work deals with technological considerations required to optimize the cutting data and tool path pattern for finishing the milling of free-form surfaces made of steel in a hardened state. In terms of technological considerations, factors such as feed rate, workpiece geometry, tool inclination angles (lead and tilt angles) and surface roughness are taken into account. The proposed method is based on calculations of the cutting force components and surface roughness measurements. A case study presented in the paper is based on the AISI H13 steel, with hardness 50 HRC and milling with a cubic boron nitride (CBN) tool. The results of the research showed that by modifications of the feed value based on the currently machined cross-sectional area, it is possible to control the cutting force components and surface roughness. During the process optimization, the 9% and 15% increase in the machining process efficiency and the required surface roughness were obtained according to the tool inclination angle and feed rate optimization procedure, respectively.
Adaptive Output Synchronization of General Complex Dynamical Network with Time-Varying Delays
Authors: Gan Liangzhi , Li Shuo , Duan Na , Kong Xiangyong
Published: March 2020

This paper is concerned with the output synchronization problems for a class of delayed complex dynamical networks. Based on the invariant principle of functional differential equations and Lyapunov stability theory, the feedback controller and parameter update laws are constructed for a large-scale network with uncertainties. The general complex delayed network can achieve synchronization by adaptively adjusting their feedback gains. Numerical examples are presented to further verify the effectiveness of the proposed control scheme.
Novel Multiple Attribute Group Decision-Making Methods Based on Linguistic Intuitionistic Fuzzy Information
Authors: Rong Yuan , Liu Yi , Pei Zheng
Published: March 2020

As an effective technique to qualitatively depict assessment information, a linguistic intuitionistic fuzzy number (LIFN) is more appropriate to portray vagueness and indeterminacy in actual situations than intuitionistic fuzzy number (IFN). The prominent feature of a Muirhead mean (MM) operator is that it has the powerful ability to capture the correlations between any input-data and MM operator covers other common operators by assigning the different parameter vectors. In the article, we first analyze the limitations of the existing ranking approaches of LIFN and propose a novel ranking approach to surmount these limitations. Secondly, we propound several novel MM operators to fuse linguistic intuitionistic fuzzy (LIF) information, such as the LIF Muirhead mean (LIFMM) operator, the weighted LIF Muirhead mean (WLIFMM) operator and their dual operators, the LIFDMM operator and the WLIFDMM operator. Subsequently, we discuss several desirable properties along with exceptional cases of them. Moreover, two novel multiple attribute group decision-making approaches are developed based upon these operators. Ultimately, the effectuality and practicability of the propounded methods are validated through dealing with a global supplier selection issue, and the comparative analysis and the merits of the presented approaches are demonstrated by comparing them with existing approaches.
Hallucinations after Cardiac Surgery: A Prospective Observational Study
Authors: Ottens Thomas H. , Sommer Iris E.C. , Begemann Marieke J. , Schutte Maya , Cramer Maarten Jan , Suyker Willem J. , Van Dijk Diederik , Slooter Arjen J.C.
Published: March 2020

Background and Objective: Hallucinations after cardiac surgery can be a burden, but their prevalence and phenomenology have not been studied well. Risk factors for postoperative hallucinations, as well as their relation to delirium are unclear. We aimed to study the prevalence and phenomenology of hallucinations after cardiac surgery, and to study the association between hallucinations and delirium in this population. Materials and Methods: We used the Questionnaire for Psychotic Experiences to detect hallucinations in cardiac surgery patients and a control group of cardiology outpatients. We assessed postoperative delirium with validated instruments. Risk factors for postoperative hallucinations and the association between hallucinations and delirium were analysed using logistic regression. Results: We included 201 cardiac surgery patients and 99 cardiology outpatient controls. Forty-four cardiac surgery patients (21.9%) experienced postoperative hallucinations in the first four postoperative days. This was significantly higher compared to cardiology outpatient controls (n = 4, 4.1%, p < 0.001). Visual hallucinations were the most common type of hallucinations in cardiac surgery patients, and less common in outpatient controls. Cardiac surgery patients who experienced hallucinations were more likely to also have delirium (10/44, 22.7%) compared to patients without postoperative hallucinations (16/157, 10.2% p = 0.03). However, the majority of patients with postoperative hallucinations (34/44, 77.3%) did not develop delirium. Conclusion: After cardiac surgery, hallucinations occurred more frequently than in outpatient controls. Hallucinations after cardiac surgery were most often visual in character. Although postoperative hallucinations were associated with delirium, most patients with hallucinations did not develop delirium.
Robust Ag-Cu Sintering Bonding at 160 °C via Combining Ag2O Microparticle Paste and Pt-Catalyzed Formic Acid Vapor
Authors: He Liangliang , Li Junlong , Wu Xin , Mu Fengwen , Wang Yinghui , Lu Yangting , Suga Tadatomo
Published: March 2020

With the assistance of Pt-catalyzed formic acid vapor, robust Ag-Cu bonding was realized at an ultra-low temperature of 160 °C under 3 MPa for 30 min via the sintering of Ag nanoparticles in situ generated from Ag2O microparticles. The Cu oxide layer at the interface after bonding can be eliminated, which improves the bond strength and electrical conductivity of the joint. A metallic bond contact between the sintered Ag and the Cu substrate is obtained without interfacial solid solution and intermetallic phases, and the shear strength is comparable to previous bonding at a higher temperature. The bonding mechanisms were figured out by comparing the bonding with and without the Pt-catalyzed formic acid vapor. This ultra-low temperature Ag-Cu bonding method may create more flexibilities in the structure design and material selection for power device integration.
The Adsorption Behavior of Moisture on Smelter Grade Alumina during Transportation and Storage—for Primary Aluminum Production
Authors: Yang Youjian , Tao Wenju , Liu Weicheng , Hu Xianwei , Wang Zhaowen , Shi Zhongning , Shu Xin
Published: March 2020

Smelter grade alumina (SGA) plays multiple roles in the Hall–Héroult process for primary aluminum production. Given its very porous nature, one major role of SGA is to adsorb toxic hydrogen fluoride (HF) in the dry scrubber. However, also because of its porous nature, SGA inevitably adsorbs ambient moisture. This paper discusses the influence of alumina properties, including pore size distribution and specific surface area, on the physical adsorption of water vapor on SGA, as well as the adsorption kinetics. The result shows that the adsorption enthalpy of moisture on SGA is in the range of 4–13 kJ/mol. The adsorption capacity increases significantly with the particle specific surface area and total pore volume. A higher adsorption temperature indicates a much faster adsorption rate but corresponds to a lower equilibrium adsorption capacity.
Manufacturing and Applications of Stainless Steels
Authors: Di Schino Andrea
Published: March 2020

Stainless steels represent quite an interesting material family, both from a scientific and commercial point of view, owing to their excellent qualities in terms of strength and ductility, combined with corrosion resistance [...]
Integrative Metabolomics for Assessing the Effect of Insect (Hermetia illucens) Protein Extract on Rainbow Trout Metabolism
Authors: Roques Simon , Deborde Catherine , Guimas Laurence , Marchand Yann , Richard Nadège , Jacob Daniel , Skiba-Cassy Sandrine , Moing Annick , Fauconneau Benoit
Published: March 2020

Nutrition of high trophic species in aquaculture is faced with the development of sustainable plant-based diets. Insects seem particularly promising for supplementing plant-based diets. However, the complex effect of whole insect meal on fish metabolism is not well understood, and even less is known about insect meal extracts. The purpose of this work was to decipher the metabolic utilization of a plant-based diet supplemented with the gradual addition of an insect protein extract (insect hydrolysate at 0%, 5%, 10% and 15%). 1H-NMR profiling was used to assess metabolites in experimental diets and in fish plasma, liver and muscle. A significant dose-dependent increase in growth and feed efficiency with increasing insect extract amounts was observed. The incremental incorporation of the insect extract in diet had a significant and progressive impact on the profile of dietary soluble compounds and trout metabolome. The metabolites modulated by dietary insect extracts in plasma and tissues were involved in protein and energy metabolism. This was associated with the efficient metabolic use of dietary free amino acids toward protein synthesis through the concomitant supply of balanced free amino acids and energy substrates in muscle. The findings provide new insights into how the dietary food metabolome affects fish metabolism.
Identification and Validation of Metabolic Markers for Adulteration Detection of Edible Oils Using Metabolic Networks
Authors: Dou Xinjing , Zhang Liangxiao , Wang Xiao , Yang Ruinan , Wang Xuefang , Ma Fei , Yu Li , Mao Jin , Li Hui , Wang Xiupin , Li Peiwu
Published: March 2020

Food adulteration is a challenge faced by consumers and researchers. Due to DNA fragmentation during oil processing, it is necessary to discover metabolic markers alternative to DNA for adulteration detection of edible oils. However, the contents of metabolic markers vary in response to various factors, such as plant species, varieties, geographical origin, climate, and cultivation measures. Thus, it is difficult to identify a universal marker for all adulterants that may be present in some authentic samples. Currently, the specificity and selectivity of metabolic biomarkers are difficult to validate. Therefore, this study developed a screening strategy based on plant metabolic networks by developing a targeted analytical method for 56 metabolites in a metabolic network, using liquid/liquid extraction–liquid chromatography–tandem mass spectrometry (LC-MS/MS). We identified a chain of 11 metabolites that were related to isoflavonoid biosynthesis, which were detected in soybean oils but not rapeseed oils. Through multiple-marker mutual validation, these metabolites can be used as species-specific universal markers to differentiate soybean oil from rapeseed oil. Moreover, this method provides a model for screening characteristic markers of other edible vegetable oils and foods.
Analysis and Simulation of Glioblastoma Cell Lines-Derived Extracellular Vesicles Metabolome
Authors: Čuperlović-Culf Miroslava , Khieu Nam H. , Surendra Anuradha , Hewitt Melissa , Charlebois Claudie , Sandhu Jagdeep K.
Published: March 2020

Glioblastoma (GBM) is one of the most aggressive cancers of the central nervous system. Despite current advances in non-invasive imaging and the advent of novel therapeutic modalities, patient survival remains very low. There is a critical need for the development of effective biomarkers for GBM diagnosis and therapeutic monitoring. Extracellular vesicles (EVs) produced by GBM tumors have been shown to play an important role in cellular communication and modulation of the tumor microenvironment. As GBM-derived EVs contain specific “molecular signatures” of their parental cells and are able to transmigrate across the blood–brain barrier into biofluids such as the blood and cerebrospinal fluid (CSF), they are considered as a valuable source of potential diagnostic biomarkers. Given the relatively harsh extracellular environment of blood and CSF, EVs have to endure and adapt to different conditions. The ability of EVs to adjust and function depends on their lipid bilayer, metabolic content and enzymes and transport proteins. The knowledge of EVs metabolic characteristics and adaptability is essential for their utilization as diagnostic and therapeutic tools. The main aim of this study was to determine the metabolome of small EVs or exosomes derived from different GBM cells and compare to the metabolic profile of their parental cells using NMR spectroscopy. In addition, a possible flux of metabolic processes in GBM-derived EVs was simulated using constraint-based modeling from published proteomics information. Our results showed a clear difference between the metabolic profiles of GBM cells, EVs and media. Machine learning analysis of EV metabolomics, as well as flux simulation, supports the notion of active metabolism within EVs, including enzymatic reactions and the transfer of metabolites through the EV membrane. These results are discussed in the context of novel GBM diagnostics and therapeutic monitoring.
An In-Line Fiber Optic Fabry–Perot Sensor for High-Temperature Vibration Measurement
Authors: Chen Dong , Qian Jiang , Liu Jia , Chen Baojie , An Guowen , Hong Yingping , Jia Pinggang , Xiong Jijun
Published: March 2020

An in-line fiber optic Fabry–Perot (FP) sensor for high-temperature vibration measurement is proposed and experimentally demonstrated in this paper. We constructed an FP cavity and a mass on single-mode fibers (SMFs) by fusion, and together they were inserted into a hollow silica glass tube (HST) to form a vibration sensor. The radial dimension of the sensor was less than 500 μm. With its all-silica structure, the sensor has the prospect of measuring vibration in high-temperature environments. In our test, the sensor had a resonance frequency of 165 Hz. The voltage sensitivity of the sensor system was about 11.57 mV/g and the nonlinearity was about 2.06%. The sensor could work normally when the temperature was below 500 °C, and the drift of the phase offset point with temperature was 0.84 pm/°C.