bluuebunny/crossref_metadata_2025 huggingface dataset:
Formate production is dispensable for
Haemophilus ducreyi
virulence in human volunteers
Authors: Brothwell Julie A. , Fortney Kate R. , Williams Jalan S. , Batteiger Teresa A. , Duplantier Rory , Grounds Danielle , Jannasch Amber S. , Katz Barry P. , Spinola Stanley M.
Published: August 2023

Haemophilus ducreyi
is a causative agent of cutaneous ulcers in children who live in the tropics and of the genital ulcer disease chancroid in sexually active persons. In the anaerobic environment of abscesses and ulcers, anaerobic respiration and mixed acid fermentation (MAF) can be used to provide cellular energy. In
Escherichia coli
, MAF produces formate, acetate, lactate, succinate, and ethanol; however, MAF has not been studied in
H. ducreyi
. In human challenge experiments with
H. ducreyi
35000HP, transcripts of the formate transporter FocA and pyruvate formate lyase (PflB) were upregulated in pustules compared to the inocula. We made single and double mutants of
focA
and
pflB
in 35000HP. Growth of 35000HPΔ
focA
was similar to 35000HP, but 35000HPΔ
pflB
and 35000HPΔ
focA-pflB
had growth defects during both aerobic and anaerobic growth. Mutants lacking
pflB
did not secrete formate into the media. However, formate was secreted into the media by 35000HPΔ
focA
, indicating that
H. ducreyi
has alternative formate transporters. The pH of the media during anaerobic growth decreased for 35000HP and 35000HPΔ
focA
, but not for 35000HPΔ
pflB
or 35000HPΔ
focA-pflB
, indicating that
pflB
is the main contributor to media acidification during anaerobic growth. We tested whether formate production and transport were required for virulence in seven human volunteers in a mutant versus parent trial between 35000HPΔ
focA-pflB
and 35000HP. The pustule formation rate was similar for 35000HP (42.9%)- and 35000HPΔ
focA-pflB
(62%)-inoculated sites. Although formate production occurs during
in vitro
growth and
focA-pflB
transcripts are upregulated during human infection,
focA
and
pflB
are not required for virulence in humans.
ZnS nanoparticles prepared by Prunus persica leaf extract: Morphological, optical and electrical properties
Authors: Abdul Rauf Khan M. , Iqbal Tariq , Bano Ayesha , Mahmood Hasan , Mehood Ansar
Published: August 2023

As compared to conventional physical and chemical techniques, the biological method (green synthesis) is an economical, nontoxic, fast, eco-friendly and cost-effective technique that utilizes plant extract to generate highly stable and biocompatible nanoparticles. The existing study focuses on the synthesis of zinc sulphide nanoparticles (ZnS NPs) using P. persica leaf extract which is used as a reducing agent and their associated properties. The prepared samples were examined in terms of structural, optical, morphological and compositional properties. The SEM images showed the agglomerated spherical particles while XRD spectra confirmed the hexagonal (wurtzite) phase of synthesized ZnS samples with average crystallite sizes found to vary from 12.45 to 14.36[Formula: see text]nm. The optical absorption spectra displayed the absorption peaks at 331[Formula: see text]nm (4.26[Formula: see text]eV) and 339[Formula: see text]nm (4.10[Formula: see text]eV). This blue shift in the absorption band suggests the formation of ZnS NPs compared with bulk ZnS ([Formula: see text][Formula: see text]eV) material. The FTIR peaks from 612– to 630[Formula: see text]cm[Formula: see text] and 860– to 1022[Formula: see text]cm[Formula: see text] are because of the symmetric bending vibrations of the Zn–S bands. Electrical measurements showed that the resistivity is found to be decreasing with increasing temperature, signifying the semiconducting behavior of the synthesized ZnS NPs. The findings of this study suggest the feasible use of P. persica leaves extract for the production of ZnS NPs which could be utilized as multifunctional material in medical applications, biosensors, photocatalytic and electrical applications.
Sound absorption mechanism of sonic black hole with labyrinthine units and micro perforated panel
Authors: Liang Xiao , Chu Jiaming , Ouyang Xiangjun , Yang Qifu , Zhou Zhuo , Liang Haofeng , Yang Zhen , Su Liang , Wang Wenjie
Published: August 2023

Acoustic black hole (ABH) is a technique capable of manipulating the propagation of flexural wave, and the sonic black hole (SBH) is a kind of ABH which is used to manipulate sound wave in a fluid medium. In this paper, we propose an SBH structure with labyrinthine units and combine with micro-perforated panel (MPP) to form a composite sound absorption structure. The sound absorption mechanism of the absorption structure is deeply investigated using numerical and simulation methods. The simulation reveals the sound absorption mechanism by acoustic streaming effects of composite sound absorption structure. We analyze the flow characteristics of the acoustic medium under acoustic excitation, and the effect of the flow field on the distribution of the acoustic field, and the energy dissipation distribution. Our theoretical results show that the sound absorption is attributed to the effects of sound energy focusing of ABH, the local resonance of MPP, and the acoustic energy localization and dissipation effect of labyrinthine units caused by large flow velocity gradients. Finally, the proposed composite sound absorption structure has good sound absorption performance, which is also confirmed by impedance tube experiments. It can provide a new way of thinking for the design and optimization of the SBH structure.
Influencing factors and current threshold conditions of jet forming for liner structures under electromagnetic loading
Authors: Wang Yawei , Wang Shuyou , Jiang Jianwei , Men Jianbing , Chen Guojun
Published: August 2023

In order to study the forming mechanism of metal jet under electromagnetic loading, numerical simulation for electromagnetic coupled jet forming was realized by using AUTODYN software with secondary development. Through secondary development, the magnetic pressure on the liner during the collapse process is calculated iteratively, which enables numerical simulation for electromagnetically coupled jets. The influence and threshold condition of electromagnetic parameters for jet forming are obtained through this. The results show that the head velocity and length of the jet are improved for liner without a tip. The electromagnetic parameters and structural parameters need to match with each other. The head velocity and effective length of the jet increase with the increase in wall thickness and cone angle. The liner diameter has little effect on the head velocity and effective length of the jet. The head velocity and effective length of the jet first increase and then decrease with the increase in cone radius.
Application Improvement of Deep Learning Algorithm in Small-Sized Fittings, Voltage Balancing Ring and Bare Conductor Detection of Transmission Lines
Authors: Zhou Shengcheng , Tai Shujie , Zhang Longji , Cheng Dan , Zhu Lina , Li Yujie , Ye Xuwei
Published: August 2023

As technological advancements progress and energy conservation and emission reduction policies gain traction, an increasing amount of clean energy is being integrated into the power grid system. This influx of new energy imposes stringent demands on the transmission lines within the power grid system. In recent years, the State Grid has implemented a plethora of intelligent transmission line inspection strategies, with the intelligent inspection of Unmanned Aerial Vehicle (UAV) transmission lines receiving significant promotion and widespread application. However, practical application has revealed that the prevalent transmission line detection algorithms yield a substantial quantity of false detections, particularly in the detection of nut defects in small-sized metallic fittings, voltage balancing ring defects, and defects in uninsulated conductors. To address these issues, this paper employs deep learning algorithms for target detection, critical point detection, and instance segmentation, focusing on aspects such as algorithmic logic, algorithmic models, and data processing. The aim is to enhance the precision of these three types of defect detection, diminish the rate of false detections, and augment the practicality of intelligent grid inspection.
Tomato Production Prediction Based on Deep Learning Algorithm-Cascade-PSPNET and Bayes
Authors: Qi Chenchen , Liu Weizhong
Published: August 2023

Accounting the problem of small sample size in tomato yield statistics, a dual-fusion prediction analysis model based on Bayes theory and deep learning algorithm Cascade-PSPNET is proposed. The tomato yield prediction is conducted based on remote sensing image time series analysis and multi-source information fusion theory with Bayesian theory and credibility weighting. First, the area of tomato planting is analyzed through semantic segmentation algorithms of remote sensing images during the tomato planting process. The yield is predicted by variables such as planting area fluctuation, disaster cycle fluctuation, etc. Through analyzing the reduced yield affected by disasters in different time periods of remote sensing images during planting process, the value chain of tomato industry is calculated by comprehensively analyzing price-value system, inflation coefficient, and unit area yield. At the same time, the annual patent application volume is used to predict the change of tomato yield year by year according to Bayesian theory, and the relationship between annual patent application volume and tomato yield year by year under different confidence levels is analyzed. The results show that it is feasible to use the Bayes method with semantic segmentation algorithms of remote sensing images to predict tomato yield. Next, the experiment of fusion prediction between two prediction models in the same target area will be carried out for verification.
Correlation Structure of the Solution to the Reaction-Diffusion Equation in Respond to Random Fluctuations of the Boundary Conditions
Authors: Sabelfeld Karl
Published: August 2023

In this paper, we deal with the reaction-diffusion equation subject to Dirichlet and Neumann boundary conditions where the input function on the boundary is randomly fluctuated. First we study the fundamental case when this function is a white noise. Explicit form of the correlation function is derived for the reaction-diffusion equation in a half-plane. In this case we obtain the Karhunen–Loève expansion (KL) of the solution which is a partially homogeneous random field, i.e., it is homogeneous along the horizontal direction, and is inhomogeneous in the vertical direction. Then, based on this representation, we extend this result to the general case when the function prescribed on the boundary is an arbitrary homogeneous random field.
Impact of Non-Gaussian Noise and Time Delay on Stability and Stochastic Resonance for a FitzHugh-Nagumo Neural System Subjected to a Multiplicative Periodic Signal
Authors: Chen Yun-Feng , Wang Kang-Kang , Ye Hui , Wang Ya-Jun
Published: August 2023

In this paper, we focus on the investigations on the stochastic stability and the stochastic resonance (SR) phenomena for a FitzHugh-Nagumo system with time delay induced by a multiplicative non-Gaussian colored noise and an additive Gaussian colored noise. By use of the fast descent method, the unified colored noise approximation and the two-state theory for the SR, the stationary probability density function (SPDF) and the signal-to-noise ratio (SNR) caused by different noise terms and time delay are explored. The investigation results indicate that the two noise intensities, time delay and the departure parameter from the Gaussian noise can all reduce the probability density around the two stable states and destroy the stability of the neural system; while the two noise correlation times [Formula: see text] and [Formula: see text] can both improve the probability density around both stable states and reinforce the biological stability of the neural system. As regards the SNR, it is found that the two noise intensities and the departure coefficient can all weaken the SR effect, while time delay [Formula: see text] and the correlation time [Formula: see text] of the multiplicative noise will always magnify the SR phenomenon. It is worth to mention that the correlation time [Formula: see text] of the additive noise can stimulate the SR effect, but not alter the maximum of the SNR.
Finite solvable groups with a nilpotent normal complement subgroup
Authors: Amiri Mohsen
Published: August 2023

Let [Formula: see text] be a finite solvable group and [Formula: see text] a non-normal core-free solvable subgroup of [Formula: see text]. We show that if the normalizer of any nontrivial normal subgroup of [Formula: see text] is equal to [Formula: see text], then [Formula: see text] has a nilpotent normal complement [Formula: see text] such that [Formula: see text] and [Formula: see text] is a Frobenius group.
Nonlinear mixed ∗-Jordan type derivations on alternative ∗-algebras
Authors: Carnieri Pierin Tanise , Ferreira Ruth Nascimento , Borges Fernando , Ferreira Bruno Leonardo Macedo
Published: August 2023

Let [Formula: see text] be a unital alternative ∗-algebra with a distinguished idempotent element. In this paper, it is shown that a map is a nonlinear mixed ∗-Jordan type derivation on [Formula: see text] if and only if it is an additive ∗-derivation. As an application, one gets a result on alternative [Formula: see text]-algebras.
Design and Control of a Novel Hydraulic-Driven Humanoid Hand
Authors: Tao Zhenguo , Li Xu , Feng Haibo , Fu Yili
Published: August 2023

The robots with humanoid hands can take the place of humans in carrying objects and using tools efficiently in different situations. This paper presents a novel hydraulic-driven robotic hand named the WLRH-II (the second-generation wheel-legged robot humanoid hand) which bears heavy load and has strong robustness. This paper focuses on the design of humanoid hand driving and transmission mechanisms, kinematic and static analyses. First, the linkage mechanism is proposed according to the particle swarm optimization algorithm. Then, the kinematics and the statics of WLRH-II are analyzed in grasp state. In addition, the hydraulic servo control method is used to control the position of a hand through angle feedback. Finally, position tracking and load experiments are completed to verify the reasonableness and effectiveness of the control. The robotic hand can grasp objects of 30[Formula: see text]kg with 2.85-kg self-weight. The WLRH-II has a high load/self-weight ratio of 10.55 in this paper, which is rare in similar humanoid robotic hands.
Indonesian Foreign Policy under the Jokowi Administration: Variations on Traditional Ideas
Authors: WARDHANI BAIQ , DUGIS VINSENSIO
Published: August 2023

Since independence in 1945, Indonesia has managed to carry out its foreign policy according to a unique doctrine described as “independent and active” (bebas dan aktif). To be independent means that Indonesia does not side with world powers, while being active means vigorously carrying out peaceful policies and actively participating in the peaceful settlement of international issues. The doctrine is not a neutral policy but does not align and bind the country with the superpowers or any military pact. Instead, being independent and active primarily serves the national interest while allowing the Indonesian government to collaborate with other nations. However, the doctrine’s implementation has varied according to the different interpretations of successive presidents. This paper explains Indonesia’s independent and active foreign policy during President Joko Widodo’s presidency. It contends that while the doctrine has continued to underlie Indonesia’s foreign policy, the formulation of President Joko Widodo’s foreign policy is unique in its practical approach, prioritizing the national interest and the domestic advantages of foreign relations. In the president’s worldview, foreign policy has been instrumental in promoting the nation’s development.
Linear hash functions and their applications to error detection and correction
Authors: Ryabko Boris
Published: August 2023

We describe and explore so-called linear hash functions and show how they can be used to build error detection and correction codes. The method can be applied for different types of errors (for example, burst errors). When the method is applied to a model where the number of distorted letters is limited, the obtained estimate of its performance is slightly better than the known Varshamov–Gilbert bound. We also describe random code whose performance is close to the same boundary, but its construction is much simpler. The proposed error correction codes are close to those obtained in the theory of linear codes, but there are examples when the proposed algorithms are more efficient.
Local Path Planning for Nonholonomic Mobile Robots Based on Planar G2 Pythagorean Hodograph Degree 7 Bezier Transition Curves
Authors: Liang Jianjian , Wang Shoukun , Wang Bo
Published: August 2023

The paper proposes a method that joins two line segments using planar Pythagorean hodograph (PH) degree 7 Bezier transition curves. The objective is to make use of such curvature-continuous curves for the path planning of nonholonomic constrained vehicles moving in 2D space, which requires designing a smooth path while satisfying the constraint of minimum turning radius. We initially present a novel idea that employs PH degree 7 Bezier transition curves for dealing with curvature constraints, the result of which proves to be better than the traditional method based on the “forward simulation”. The properties of PH degree 7 Bezier transition curves are then fully analyzed showing that the curves can be determined by a minimum of three parameters, each of which has an intuitive geometric meaning. The paper also proposes a path planner with direct curvature constraints during the process of path generation in 2D space. The objective function of the optimal path generation can be adjusted to minimize the length of the whole path or to closely follow the original global nonsmooth sequences of line segments. Here, the optimization problem is tactfully converted to a linear programming problem that can be solved efficiently. Finally, we use a kinematic bicycle model for simulation and compare the results with those from Dubins path showing that a [Formula: see text] curve is easier to follow than a [Formula: see text] one.
i-Sample: Augment Domain Adversarial Adaptation Models for WiFi-based HAR
Authors: Zhou Zhipeng , Wang Feng , Gong Wei
Published: August 2023

Recently, using deep learning to achieve WiFi-based human activity recognition (HAR) has drawn significant attention. While capable of achieving accurate identification in a single domain (i.e., training and testing in the same consistent WiFi environment), it would become extremely tough when WiFi environments change significantly. As such, domain adversarial neural networks-based approaches have been proposed to handle such diversities across domains, yet often found to share the same limitation in practice: the imbalance between high-capacity of feature extractors and data insufficiency of source domains.

This article proposes i-Sample, an intermediate sample generation-based framework, striving to tackle this issue for WiFi-based HAR. i-Sample is mainly designed as two-stage training, where four data augmentation operations are proposed to train a coarse domain-invariant feature extractor in the first stage. In the second stage, we leverage the gradients of classification error to generate intermediate samples to refine the classifiers together with original samples, making i-Sample also capable to be integrated into most domain adversarial adaptation methods without neural network modification. We have implemented a prototype system to evaluate i-Sample, which shows that i-Sample can effectively augment the performance of nowadays mainstream domain adversarial adaptation models for WiFi-based HAR, especially when source domain data is insufficient.
Impedance Response Influenced by Variability in the Random Distribution of Physical Properties of Coated Materials in Two-Dimensional Space
Authors: Cho Seongkoo , Kim Changkyu , Castaneda Homero
Published: August 2023

Heterogeneous physical characteristics of a system featuring a single-layer film on a metallic surface have been explored via its impedance response. The Nyquist plot showed a distorted semicircle, indicative of the system’s unique distribution characteristics. Utilizing a copula-based probability method, a two-dimensional deterministic impedance model was successfully integrated, accounting for spatial physical properties such as permittivity and electrical conductivity. This strategy enabled in-depth exploration and mechanistic quantification of a broad spectrum of properties. A quantitative understanding of impedance signal alterations, characterized by normally or log-normally correlated variables, was achieved through the variation in aspect ratio and characteristic frequency of the impedance spectra. Log-normally distributed electrical properties provided a superior representation of the distorted impedance spectra. As coefficient of variation (CV) values fluctuated, the aspect ratio and characteristic frequency showed heightened sensitivity to log-normal permittivity compared to log-normal electrical conductivity. Notably, a marked positive linear correlation between electrical properties resulted in an impedance response that approximated perfect semicircular spectra. The variability in the electrical properties’ distribution was demonstrated by considering the correlation coefficient between electrical conductivity and the z-direction position. The highest aspect ratio of the impedance spectra was observed when the electrical conductivity was randomly distributed across the z-direction space.
The Approximate Solutions of Large Deflection of a Cantilever Beam under a Point Load
Authors: Meng Baochen , Lian Chencheng , Zhang Jun , Jing Huimin , Wu Rongxing , Wang Ji
Published: August 2023

By integrating the physical and time domains with the Galerkin method and adopting approximate solutions satisfying the boundary conditions, a set of algebraic equations of nonlinear nature is obtained from the nonlinear differential equation of an elastic beam for the undetermined coefficients of solutions of the deflection. These coefficients are to be used with the approximate basis functions for the asymptotic and explicit solutions of the nonlinear differential equation of flexure of a beam widely known as an elastica. Taking advantage of powerful tools for the symbolic manipulation of algebraic equations, such a novel method and procedure offer a new and efficient approach and option with known linear solutions in dealing with increasingly complex nonlinear problems in practical applications of both static and dynamic nature.
The Effect of Temperature on the Distribution of Zoonotic Pathogens in Livestock and Wildlife Populations: A Systematic Review
Authors: Becvarik Zoe A. , Smurthwaite Kayla S. , Lal Aparna
Published: August 2023

Background. Evidence for the impact of climate change on the distribution of zoonoses has largely focussed on the burden in humans and is lacking information on the effect of temperature on nonvectorborne zoonoses that are transmitted indirectly through contaminated environments. We present a systematic literature review on the impact of temperature on the distribution of zoonotic pathogens in mammalian livestock and wildlife populations, with a focus on nonvectorborne zoonoses that can be spread through air, water, food, and soil. Methods. We systematically searched PubMed, Scopus, and Web of Science, as well as grey literature, and screened titles, abstracts, and full text. English, peer-reviewed, and full text studies were included if they: focused on temperature; considered incursion, distributional burden or risk; and focused on a zoonotic pathogen in livestock and/or wildlife populations of mammalian vertebrates that can be transmitted through indirect pathways without a nonmammalian and nonvertebrate intermediate host. Results. Temperature was an important determinant of zoonoses distribution across all 17 studies included in the final review, with 11 studies finding a positive association. The majority of studies focused on parasites (7) and bacteria (9) and were conducted in the northern hemisphere. Two studies provided future climate projections that identified areas of increasing prevalence and expanded risk for pathogens that were already established. However, no studies specifically investigated the risk of zoonotic incursion with increasing temperature. Few studies explored how local variations in temperature and urbanisation interact with distal changes like Arctic warming to affect the distribution and spread of nonvectorborne pathogens through food, water, and soil. Conclusions. The review’s findings point to the value of a One Health approach to biosecurity that builds on the interconnected relationship between human, animal, plant, and environmental health. Such research is urgently needed to inform the prioritisation and risk assessment of zoonoses more comprehensively in a rapidly changing climate.
Effects of rAAV-Mediated Overexpression of sox9 and TGF-ß via Alginate Hydrogel-Guided Vector Delivery on the Chondroreparative Activities of Human Bone Marrow-Derived Mesenchymal Stromal Cells
Authors: Liu Wei , Venkatesan Jagadeesh K. , Amini Mahnaz , Oláh Tamás , Schmitt Gertrud , Madry Henning , Cucchiarini Magali
Published: August 2023

Recombinant adeno-associated virus (rAAV) vectors have a strong potential to promote the healing of traumatic cartilage defects and osteoarthritic lesions upon delivery and overexpression of therapeutic genes from suitable biomaterials that support a controlled release of the candidate constructs. The goal of the present work is to examine whether the administration of chondrogenic rAAV sox9 and rAAV TGF-ß gene vehicles via alginate hydrogel-guided vector delivery stimulates the biological and chondroreparative activities of human bone marrow-derived mesenchymal stromal cells (hMSCs) as a source of improved reparative cells for future implantation in sites of cartilage damage. The delivery of rAAV using an alginate (AlgPH155) hydrogel system is successfully achieved in hMSCs over time (21 days), leading to the effective overexpression of sox9 and TGF-ß that significantly increases the proliferation and chondrogenic differentiation activities of the cells relative to control (marker lacZ) gene transfer while advantageously preventing premature hypertrophy, osteogenesis, and mineralization. This study reveals the potential of alginate hydrogel-based systems to control the delivery of rAAV (sox9 and TGF-ß) gene vectors to adeptly trigger the chondroreparative activities of hMSCs for future applications that aim at improving cartilage repair.
Ongoing Increase in Incidence of Diabetes in Austrian Children and Adolescents (1989–2021): Results from a Nationwide Registry
Authors: Nagl Katrin , Waldhör Thomas , Hofer Sabine E. , Blauensteiner Nicole , Fritsch Maria , Fröhlich-Reiterer Elke , Rami-Merhar Birgit
Published: August 2023

Introduction. Since there is no uniform global diabetes trend in childhood and adolescence, regional epidemiological surveys of diabetes incidences are important. In Austria, the incidences of type 1 diabetes (T1D), type 2 diabetes (T2D), and other forms of diabetes have been recorded for decades. Methods. To analyze recent developments of diabetes incidence within the decades long-standing Austrian nationwide prospective population-based incidence study for diabetes in children aged <15 years. We estimated time trends of age-standardized rates from 1989 to 2021 for T1D and T2D by joinpoint analysis. Annual percent changes (APCs) were calculated. Case ascertainment was 97%. Results. We observed an unusual increase of T1D incidence in the year 2021, reaching a peak of 28.7/100,000/PY (person years). From 2011 to 2020, there had been a constant plateau phase in the total cohort (APC 0.78, 95% CI [−0.99, 2.58],

p
=
0.379

), which had followed a steep increase of T1D incidence (APC 4.6, 95% CI [3.94, 5.19],

p
<
0.001

) from 1989 to 2011. Age-specific differences in T1D incidence development were observed. For the first time, we observed a statistically significant constant increase in T2D during the observation period (APC 3.47, 95% CI [0.76, 6.26],

p
=
0.014

). Other forms of diabetes are two times more common than T2D in this age group. Conclusion. The incidence of T1D in Austrian children <15 years is still increasing and showed a peak in 2021. For the first time, a significant increase in pediatric T2D was observed in Austria.
Command Filter AILC for Finite Time Accurate Tracking of Aircraft Track Angle System Based on Fuzzy Logic
Authors: Zhang Chunli , Tian Xu , Gao Yangjie , Qian Fucai
Published: August 2023

In this paper, the longitudinal model of an uncertain aircraft is taken as the research object, and the aircraft path inclination is controlled by controlling the input rudder deflection angle. An adaptive iterative learning control (AILC) scheme is proposed to solve the accurate tracking control problem of the flight path inclination on a finite time interval. The aircraft track angle system is abstractly modeled to obtain a triangular model in the form of strict feedback. For the abstracted strict feedback model, the fuzzy logic is used to approximate the uncertain part of the model. A command filter and an error compensation mechanism are introduced to prevent the computational bloat problem caused by excessive system order, and a convergent series sequence is used to deal with the truncation error caused by the approximation of the fuzzy logic. Based on the Lyapunov stability theorem, all signals of the closed-loop system are bounded on the finite time interval

0
,
T

, and the output of the system can track the desired trajectory accurately. Finally, the feasibility and effectiveness of the method are verified by MATLAB simulation results.
Ureter Injury in Total Laparoscopic Hysterectomy
Authors: Kobayashi Hiroharu , Oda Aimi , Matsuzaki Yoshihiko , Kondo Yuki , Hamada Yuri , Nagashima Masaru , Kobayashi Misa , Takaki Yoshihiro , Adachi Hiroshi
Published: August 2023

Objective. To identify surgical manipulations that caused ureter injury during total laparoscopic hysterectomy (TLH) and evaluate the surgical manipulations to identify ways to prevent such injury. Patients and Methods. This single-center, cross-sectional study included 1135 cases of TLH performed for benign diseases from January 2009 to December 2021. Seven cases (0.6%) that needed ureteral stent placement intra- or postoperatively for ureter injury were included. We identified the surgical manipulations that caused ureter injury from surgical videos. Results. Two cases had adhesions around the bladder pillar, and the ureter sustained a thermal injury during the cardinal ligament transection. One case had severe endometriosis, and the ureter was bluntly damaged when the adhesion was released. In one case, the ureter was thermally damaged during bipolar hemostasis for uterine artery bleeding. In two cases, the obliterated umbilical artery was mistaken for the ureter, and the real ureter was injured. In one case, ureteral peristalsis was inhibited by a pelvic abscess caused by postoperative infection. Conclusion. To prevent ureter injury during TLH, the ureter should be isolated in case of severe adhesion. Moreover, the following could be considered: (1) expand Okabayashi’s pararectal space lateral to the uterosacral ligament, (2) perform dissection sharply using a monopolar or scissors forceps when releasing adhesion, (3) clarify the anatomy around the ureter for cases needing hemostasis, (4) repeatedly confirm the ureter with its peristalsis even after its isolation, (5) for severe adhesion cases, reduce infection risk by drain placement and administering antibiotics, and (6) use a delineator cup.
Prehospital Predictors for Urgent Neurosurgical Intervention in the Head Trauma Patient: A 2-Year Multicenter Retrospective Study
Authors: Nożewski Jakub , Kwiatkowska Maja , Łosińska Aleksandra , Nowak Ewa , Lackowska Anna , Rydzewska Anna , Durma Agnieszka , Sokal Paweł
Published: August 2023

Background. Traumatic brain injury (TBI) is the main cause of disability in the world. Prehospital diagnosis of patients requiring rapid neurosurgical intervention and the earliest possible introduction of procedures preventing secondary brain injuries (SBI) are crucial. Methodology and Study Population. The authors of this paper assumed that certain age groups with specific injuries are more likely to require urgent neurosurgical intervention compared with patients who did not require such an intervention. Out of 54,814 head CT scans, based on the inclusion criteria, 7,864 were selected for the study. Data such as sex, age, the mechanism of injury, comorbid trauma, and abnormal findings in the examination of patients qualified for urgent neurosurgical intervention were analyzed in order to find statistically significant factors through a comparison with all head trauma patients. Results. Patients qualified for urgent neurosurgical intervention were significantly older compared with the others (63 years vs. 49 years). Patients transferred from the emergency department directly to the operating room were more often admitted to the hospital due to the fall (64.1% vs. 45.1%,

p
=
0.004

). The following were observed much more commonly among the patients qualified for urgent neurosurgical intervention than in the entire study group of subjects with traumatic brain injury (TBI), e.g., calf deformity (2.2% vs. 0.1%,

p
=
0.019

) and bleeding from the mouth (4.3% vs. 0.0%,

p
<
0.001

). On the other hand, superciliary arch wounds were observed much less commonly than in the entire group (0.0% vs. 5%,

p
=
0.221

). Conclusion. Patients admitted directly to the operating neurosurgical room from emergency departments constitute a small percentage of TBI patients, and their prognosis for normal performance status upon discharge is poor. Maximum efforts should be made to distinguish these patients and to start proper treatment even during prehospital care.
Supplementary Figure S3 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Supplementary Figure S3. GPER expression grossly does not correlate with AML outcome and mutation status (A) GPER expression stratified by ELN2017. (B) GPER expression stratified by FLT3-ITD mutation status. (C) GPER expression stratified by different AML fusion proteins. All data were acquired from the BEAT-AML dataset. P-values were calculated via one-way ANOVA multiple comparisons (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001).
Supplementary Figure S14 from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

LNS8801 does not inhibit AML in systemic in vivo model (A) Proliferation assay of luciferase-expressing MV4-11 (MV4-11-Luc) cells. Cells were incubated for 72 hours and were counted with trypan blue dye. 5 replicates were used for experiment. P-values were calculated via pairwise t-tests (*p=<0.05, **p=<0.01, ***p=<0.001, ****p=<0.0001). (B) Systemic in vivo experiment done with MV4-11-Luc. Male NSG mice were used for the experiment. Mice were treated with vehicle or LNS8801 daily through oral gavage. 3 animals were used per condition.
Data from LNS8801 inhibits Acute Myeloid Leukemia by Inducing the Production of Reactive Oxygen Species and Activating the Endoplasmic Reticulum Stress Pathway
Authors: Lee Inyoung , Doepner Miriam , Weissenrieder Jillian , Majer Ariana D. , Mercado Sophia , Estell Angela , Natale Christopher A. , Sung Pamela J. , Foskett J. Kevin , Carroll Martin P. , Ridky Todd W.
Published: August 2023

Despite recent therapeutic advances, the 5-year survival rate for adults with acute myeloid leukemia (AML) is poor and standard-of-care chemotherapy is associated with significant toxicity, highlighting the need for new therapeutic approaches. Recent work from our group and others established that the G protein-coupled estrogen receptor (GPER) is tumor suppressive in melanoma and other solid tumors. We performed a preliminary screen of human cancer cell lines from multiple malignancies and found that LNS8801, a synthetic pharmacologic agonist of GPER currently in early phase clinical trials, promoted apoptosis in human AML cells. Using human AML cell lines and primary cells, we show that LNS8801 inhibits human AML in preclinical in vitro models, while not affecting normal mononuclear cells. Although GPER is broadly expressed in normal and malignant myeloid cells, this cancer-specific LNS8801-induced inhibition appeared to be independent of GPER signaling. LNS8801 induced AML cell death primarily through a caspase-dependent apoptosis pathway. This was independent of secreted classical death receptor ligands, and instead required induction of reactive oxygen species (ROS) and activation of endoplasmic reticulum (ER) stress response pathways including IRE1α. These studies demonstrate a novel activity of LNS8801 in AML cells and show that targeting ER stress with LNS8801 may be a useful therapeutic approach for AML.
Significance:
Previous work demonstrated that LNS8801 inhibits cancer via GPER activation, especially in solid tumors. Here we show that LNS8801 inhibits AML via GPER-independent mechanisms that include ROS induction and ER activation.
Factors Affecting the Quality of Financial Statements on Lembaga Perkreditan Desa in Payangan Regency
Authors: Widhiastuti Ni Luh Putu , Novitasari Ni Luh Gde , Yanti Ni Wayan Rika
Published: August 2023

The purpose of this study is to find out the effect of compliance with accounting standards, information system support, internal audit functions, leadership ethics and level of accounting understanding on the quality of financial Statements. The population of this study was 93 respondents in LPD Payangan Regency. The results of this study indicate that compliance with accounting standards, internal audit function, leadership ethics have a positive effect on the quality of financial Statements, while information system support, and the level of accounting understanding have no effect on the quality of financial statements. Further research can develop this research by using other variables that in theory have an influence on the quality of financial statements, such as professionalism and work experience.
Analysis of the Implementation of Credit Risk Management at PT. Pega-daian (Persero) Lhokseumawe Branch
Authors: Harjoni Harjoni , Asiah Nur
Published: August 2023

This study aims to determine the effectiveness of implementing credit risk management at PT. Pawnshop (Persero) Lhokseumawe Branch. The type of research used is descriptive research with a qualitative approach by explaining the application of credit risk management at PT. Pegadaian (Persero) Lhokseumawe Branch has been effective. The analysis technique used in this research is the description stage. The data analysis method used in this research is qualitative data analysis where after the collected data is processed, it is then analyzed by providing an interpretation in the form of a description. The results showed that the application of credit risk management at PT. Pegadaian (Persero) Lhokseumawe Branch was ineffective due to fluctuations in bad loans from 2016 to 2018.
Rheological Assessments on Alginate and Carrageenan as Nanoparticle Carriers for Topical Oral Cancer Drug
Authors:   Department  of  Biotechnology,  International  Islamic  Universiti  Malaysia,  Bandar  Indera  Mahkota,  25200, Kuantan, Pahang Malaysia, Burhan Nurul , Suffian Izzat ,   Department  of  Pharmaceutical  Chemistry,  Kulliyyah  of  Pharmacy,  International  Islamic University  Malaysia, Kuantan, Pahang, Malaysia, Zakaria Siti ,   Dynamical Systems and Their Applications Research Unit, Department of Computational and Theoretical Sci-ences, Kulliyyah of Sciences, International Islamic University Malaysia, Kuantan, Pahang, Malaysia, Hamzah Nurasyikin ,   Department of Chemistry, International Islamic Universiti Malaysia, Bandar Indera Mahkota, 25200, Kuantan, Pahang Malaysia, Othman Siti ,   Department  of  Biotechnology,  International  Islamic  Universiti  Malaysia,  Bandar  Indera  Mahkota,  25200, Kuantan, Pahang Malaysia
Published: August 2023

Commercially available topical oral drugs in current markets have low efficacy in delivery active load to the infected site due to poor formulation. Delivery of the active ingredients proven to be challenging as compared to skin due the presence of saliva and low shear. The aim of this project to improve formulation and characterised suitable hydrogels which later will be incorporated with nanoparticle drug for oral cancer. The gels are formulated at different pH values (4, 7, 10) and concentrations as such (0.1%, 0.15%, 0.2%, 0.25%, 0.5% and 1.0% for alginate whereas kappa-carrageenan and iota-carrageenan were formulated with 0.25%, 0.5% and 1.0%). The viscosity and zeta potential of the formulated gels are studied using HAAKE™ MARS™ rheometer and Zetasiser Nano-Z respectively. Findings revealed both 1% of kappa-carrageenan and 1% iota-carrageenan of pH 4 and pH 7 are the best candidates for nanoparticle drug delivery as the viscosity and zeta potential for 1% kappa-carrageenan (pH 4), 1% kappa-carrageenan (pH 7), 1% iota-carrageenan (pH 4), and 1% iota-carrageenan (pH 7) amongst the highest as such 70.507±6.190, 61.040±3.199, 59.490±7.799, 67.953±2.034 Pa·s, correspondingly with zeta potential value of -19.4 mV, -20.6 mV, -33.1 mV and -30.4 mV. All hydrogels formulated with different concentration were affected by pH values, by having pH value 4 and 7 appeared to have high viscosity with pseudoplastic behaviour based on the rheological profile, except for alginate due to high density sodium alginate was used in this study.
Stuart Elden. The early Foucault
Authors: Roque Jade , Alvarez Marcos César
Published: August 2023

Resenha do livro de Stuart Elden, The early Foucault, Cambridge, Polity, 2021.
Interações entre origem de classe, raça e gênero no acesso ao topo social no Brasil
Authors: Santos José Alcides Figueiredo
Published: August 2023

A desigualdade de acesso ao topo privilegiado da estrutura social no Brasil é analisada à luz das complexas interações entre origem de classe, raça e gênero. Questões de pesquisa tratam da associação total e direta entre origem e destino, a associação direta por nível educacional e os retornos econômicos da educação adotando uma abordagem de coorte para analisar as mudanças temporais. Os efeitos são estimados em probabilidades preditas usando modelos logísticos com os dados de mobilidade social da PNAD 2014. A origem de classe hierarquiza as oportunidades nos diferentes resultados, que são por sua vez modulados pelas interações entre origem, raça e gênero.
A disputa pelo “universal”: Celso Furtado, Fernando Henrique Cardoso e a arena transnacional das ciências sociais na Guerra Fria (1964-1988)
Authors: Rodrigues Lidiane Soares
Published: August 2023

Adotando a hipótese segundo a qual entre o espaço social e as construções simbólicas que nele emergem existem correlações que tornam ambos inteligíveis, o artigo articula as posições objetivas e as carreiras transnacionais que condicionaram as tomadas de posição teóricas de Celso Furtado (1920-2004) e Fernando Henrique Cardoso (1931). Trata-se de dois casos que apresentam interesse sociológico por contrariarem as tendências assimétricas do espaço global das ciências sociais: apesar de terem origem no “sul global”, suas obras foram efetivamente integradas no “centro”; disputaram explicações, ganharam paradas, perderam outras, seus pares não passaram incólumes a elas. Ademais, foram ungidos pela consagração, ainda que em países com posições diversas na hierarquia do espaço.
La « pensée plastique » de Jean-Marie Floch: pour une sémio-anthropologie des « mondes imagés »
Authors: Chatenet Ludovic
Published: August 2023

Notre article, hommage à Jean-Marie Floch, envisage de discuter la sémiotique plastique, associée aux systèmes semi-symboliques (Floch 1985, 1995) en la considérant comme fondatrice d’une approche sémio-anthropologique susceptible de prendre en charge la culture au travers de l’ensemble de ses manifestations. En remettant la sémitoque plastique en perspective avec son contexte d’apparition, dans la sémiotique greimassienne, puis avec les travaux de Lévi-Strauss qui l’ont profondément inspiré, nous entendons plus particulièrement réévaluer ses principes pour une étude des « mondes imagés ». Puisque la sémiotique plastique rend compte de la manière dont les humains construisent non seulement des « micro-scènes imagées », mais aussi des objets qui les mettent en relation avec le monde,  nous affirmerons sa pertinence pour étudier, et questionner, les nouveaux objets virtuels tels que les jeux vidéo.
The founder and his brand: plastic semiotics, semi-symbolism, and the amalgamation of corporate and private identities in the anti-ageing wellness market
Authors: Jardim Marília
Published: August 2023

Through the analysis of two brands in the health, wellness, and longevity sector — Bulletproof and Primal Blueprint — this article examines the amalgamation of brand identity and the lifestyle ideologies of the founders, creating a “total lifestyle” that exceeds the consumption of commodities. The analyses of both brands as isolated entities and the relations they construct within the sector explore the various contrasts constituting the problem of “identity” — both brand and personal, public and private — utilising concepts and methods of analysis developed throughout Jean-Marie Floch’s body of work. In particular, this article revisits his Plastic Semiotics, exploring the semi-symbolism constructed in the logos and the alimentary discourses produced by both brands. The article concludes with a reflection on the significant mechanisms marking the brands’ trajectories from dissenting actors in a sector to authoritative brands aligned with the status quo, interrogating the extent to which such trajectories are aligned with transformations in the brands’ semiotic structures.
O efeito de sentido do movimento no audiovisual: um estudo sobre o cinetismo como formante da expressão a partir da vinheta Intolerância, da Globo News
Authors: Médola Ana Silvia Lopes Davi , Pereira Henrique da Silva
Published: August 2023

A vinheta institucional Intolerância, do canal de televisão por assinatura brasileiro Globo News, constitui objeto de análise do presente artigo. Ilustrada e dirigida pelo designer israelita Noma Bar, Intolerância revela em suas estruturas discursivas como o olhar da mídia hegemônica de um país latino-americano sobre os conflitos identitários entre ocidente e oriente está alinhado com as potências ocidentais. Na esteira das contribuições teóricas desenvolvidas por Jean-Marie Floch em semiótica visual, o trabalho propõe considerar o cinetismo como formante constitutivo da visualidade em textos audiovisuais, sendo a vinheta analisada objeto notadamente exemplar para demonstrar a hipótese.