bluuebunny/crossref_metadata_2025 huggingface dataset:
Some findings from the longitudinal migration of starspots
Authors: Kaya N.Ö. , Dal H.A.
Published: April 2024

We present results regarding the longitudinal migrations of cool stellar spots that exhibit remarkable oscillations and explore their possible causes. We conducted analyses using high-quality data from nine target systems of various spectral types, spanning from F to M, which were observed by the Kepler Satellite. The systems in which the behaviour of the spots was examined are as follows: KIC 4357272, KIC 6025466, KIC 6058875, KIC 6962018, KIC 7798259, KIC 9210828, KIC 11706658, KIC 12599700, and KIC 8669092. Basic stellar parameters were calculated from light curve analysis using the PHOEBE V.0.32 software, and light curves were modelled to obtain sinusoidal variations occurring out-of-eclipses phases, induced by rotational modulation. Subsequently, we calculated the minimum times of the obtained sinusoidal variations using the Fourier transform. The distributions of

${\theta}_{\min}$

corresponding to these minimum times over time were computed using linear fits to determine the longitudinal migrations of the spotted areas. We then compared the longitudinal migration periods with the stellar parameters found in the literature. In addition, we also found a secondary variation in the spot migrations apart from the linear models. Our results revealed that the longitudinal migration periods vary in relation to the

$B-V$

colour index of the stars.
Quasi-hereditary covers of Temperley–Lieb algebras and relative dominant dimension
Authors: Cruz Tiago , Erdmann Karin
Published: April 2024

Many connections and dualities in representation theory and Lie theory can be explained using quasi-hereditary covers in the sense of Rouquier. Recent work by the first-named author shows that relative dominant (and codominant) dimensions are natural tools to classify and distinguish distinct quasi-hereditary covers of a finite-dimensional algebra. In this paper, we prove that the relative dominant dimension of a quasi-hereditary algebra, possessing a simple preserving duality, with respect to a direct summand of the characteristic tilting module is always an even number or infinite and that this homological invariant controls the quality of quasi-hereditary covers that possess a simple preserving duality. To resolve the Temperley–Lieb algebras, we apply this result to the class of Schur algebras

$S(2, d)$

and their

$q$

-analogues. Our second main result completely determines the relative dominant dimension of

$S(2, d)$

with respect to

$Q=V^{\otimes d}$

, the

$d$

-th tensor power of the natural two-dimensional module. As a byproduct, we deduce that Ringel duals of

$q$

-Schur algebras

$S(2,d)$

give rise to quasi-hereditary covers of Temperley–Lieb algebras. Further, we obtain precisely when the Temperley–Lieb algebra is Morita equivalent to the Ringel dual of the

$q$

-Schur algebra

$S(2, d)$

and precisely how far these two algebras are from being Morita equivalent, when they are not. These results are compatible with the integral setup, and we use them to deduce that the Ringel dual of a

$q$

-Schur algebra over the ring of Laurent polynomials over the integers together with some projective module is the best quasi-hereditary cover of the integral Temperley–Lieb algebra.
Race(ism) and Art Music in Argentina: Analyzing Alberto Williams’ ‘La patria y la música’ (1921)
Authors: Wolkowicz Vera
Published: April 2024

At the turn of the twentieth century, numerous Argentine intellectuals embraced positivist thinking in order to claim the ‘superiority’ of the white race and exclude the indigenous and African-descendant population from the foundational mythologies of the Argentinian nation-state. Darwin’s ideas on evolution – especially the concept of ‘survival of the fittest’ as filtered through the work of Herbert Spencer – coloured the discourses of a myriad of Argentine intellectuals, including artists. The creation of a nationalist music was a foremost concern among Argentine composers, who, influenced by these ideas, believed an Argentinian ‘high’ art should ‘elevate’ folk music through European techniques. In this paper, I concentrate on composer Alberto Williams to see how his career and relevant position in the musical milieu influenced and shaped the construction of an Argentine musical canon. I particularly focus on Williams’s speech, later published as an article, titled ‘La patria y la música’ (‘Fatherland and music’), to examine how his ideas on ‘music evolution’ and ‘race’, influenced by racial scientific ideas taken from European Positivism and Social Darwinism, shaped the discourses and development of a national (or nationalist) music in Argentina at the end of the nineteenth and through the twentieth centuries.
Longitudinal association between soft drink consumption and handgrip strength in adults: a prospective analysis from the Tianjin Chronic Low-Grade Systemic Inflammation and Health (TCLSIH) cohort study
Authors: Liu Tongfeng , Quan Shengxin , Meng Ge , Wu Hongmei , Gu Yeqing , Zhang Shunming , Wang Xuena , Zhang Juanjuan , Zhang Qing , Liu Li , Sun Shaomei , Wang Xing , Zhou Ming , Jia Qiyu , Song Kun , Fang Zhongze , Niu Kaijun
Published: April 2024

Soft drink consumption has become a highly controversial public health issue. Given the pattern of consumption in China, sugar-sweetened beverage is the main type of soft drink consumed. Due to containing high levels of fructose, a soft drink may have a deleterious effect on handgrip strength (HGS) due to oxidative stress, inflammation and insulin resistance. However, few studies show an association between soft drink consumption and HGS in adults. We aimed to investigate the association between soft drink consumption and longitudinal changes in HGS among a Chinese adult population. A longitudinal population-based cohort study (5-year follow-up, median: 3·66 years) was conducted in Tianjin, China. A total of 11 125 participants (56·7 % men) were enrolled. HGS was measured using a handheld digital dynamometer. Soft drink consumption (mainly sugar-containing carbonated beverages) was measured at baseline using a validated FFQ. ANCOVA was used to evaluate the association between soft drink consumption and annual change in HGS or weight-adjusted HGS. After adjusting for multiple confounding factors, the least square means (95 % CI) of annual change in HGS across soft drink consumption frequencies were −0·70 (–2·49, 1·09) for rarely drinks, −0·82 (–2·62, 0·97) for < 1 cup/week and −0·86 (–2·66, 0·93) for ≥ 1 cup/week (Pfor trend < 0·05). Likewise, a similar association was observed between soft drink consumption and annual change in weight-adjusted HGS. The results indicate that higher soft drink consumption was associated with faster HGS decline in Chinese adults.
Antimicrobial peptide cecropin B functions in pathogen resistance of Mythimna separata
Authors: Wang Yi-Xiao , Yang Hong-Jia , Zhang Wei-Jia , Zhao Xiao-Hui , Cui Meng-Yao , Zhang Jin-Bo , Zhang Xin-xin , Fan Dong
Published: April 2024

Mythimna separata (Lepidoptera: Noctuidae) is an omnivorous pest that poses a great threat to food security. Insect antimicrobial peptides (AMPs) are small peptides that are important effector molecules of innate immunity. Here, we investigated the role of the AMP cecropin B in the growth, development, and immunity of M. separata. The gene encoding M. separata cecropin B (MscecropinB) was cloned. The expression of MscecropinB was determined in different developmental stages and tissues of M. separata. It was highest in the prepupal stage, followed by the pupal stage. Among larval stages, the highest expression was observed in the fourth instar. Tissue expression analysis of fourth instar larvae showed that MscecropinB was highly expressed in the fat body and haemolymph. An increase in population density led to upregulation of MscecropinB expression. MscecropinB expression was also upregulated by the infection of third and fourth instar M. separata with Beauveria bassiana or Bacillus thuringiensis (Bt). RNA interference (RNAi) targeting MscecropinB inhibited the emergence rate and fecundity of M. separata, and resulted in an increased sensitivity to B. bassiana and Bt. The mortality of M. separata larvae was significantly higher in pathogen plus RNAi-treated M. separata than in controls treated with pathogens only. Our findings indicate that MscecropinB functions in the eclosion and fecundity of M. separata and plays an important role in resistance to infection by B. bassiana and Bt.
Life cycles of species of Proteocephalus, parasites of fishes in the Palearctic Region: a review
Authors: Scholz T.
Published: April 2024

The life cycles of species of Proteocephalus Weinland, 1858 (Cestoda: Proteocephalidea) parasitizing fishes in the Palearctic Region are reviewed on the basis of literary data and personal experimental observations, with special attention being paid to the development within the intermediate and definitive hosts. Planktonic crustaceans, diaptomid or cyclopid copepods (Copepoda), serve as the only intermediate hosts of all Proteocephalus species considered. A metacestode, or procercoid, develops in the body cavity of these planktonic crustaceans and the definitive host, a fish, becomes infected directly after consuming them. No previous reports of the parenteral location of metacestodes within the second intermediate host as it is in the Nearctic species P. ambloplitis have been recorded. Thus, the life cycles of Proteocephalus tapeworms resemble in their general patterns those of some pseudophyllidean cestodes such as Eubothrium or Bothriocephalus, differing from the latter in the presence of a floating eggs instead of possessing an operculate egg from which a ciliated, freely swimming larva, a coracidium, is liberated. The scolex of Proteocephalus is already formed at the stage of the procercoid within the copepod intermediate host; in this feature, proteocephalideans resemble caryophyllidean rather than pseudophyllidean cestodes. The morphology of procercoids of individual species is described with respect to the possibility of their differentiation and data on the spectrum of intermediate hosts are summarized. Procercoids of most taxa have a cercomer, which does not contain embryonic hooks in contrast to most pseudophyllidean cestodes. The role of invertebrates (alder-fly larvae — Megaloptera) and small prey fishes feeding upon plankton in the transmission of Proteocephalus tapeworms still remains unclear but these hosts are likely to occur in the life cycle. Data on the establishment of procercoids in definitive hosts, morphogenesis of tapeworms within fish hosts, and the length of the prepatent period are still scarce and new observations are needed. Whereas extensive information exists on the development of P. longicollis (syns. P. exiguus and P. neglectus), almost no data are available on the ontogeny of other taxa, in particular those occurring in brackish waters (P. gobiorum, P. tetrastomus). The morphology of P. cernuae and P. osculatus procercoids from experimentally infected intermediate hosts is described for the first time.
Photoperiodic cercarial emergence patterns of the digeneans Echinoparyphium recurvatum and Plagiorchis sp. from a mixed infection in Lymnaea peregra
Authors: McCarthy A.M.
Published: April 2024

Photoperiodic emergence patterns of the cercariae of two digeneans, Echinoparyphium recurvatum (Echinostomatidae) and Plagiorchissp. (Plagiorchiidae), were studied experimentally using a photoperiodic regime of 12 h light: 12 h dark at a constant 18°C. In single species infections of the first intermediate host snail Lymnaea peregra, the cercariae of E. recurvatum emerged exclusively during the light phase and those of Plagiorchis sp. emerged exclusively during the dark phase. In double infections, each species retained its own discrete photoperiodic emergence pattern. This result demonstrates the absence of interference between the mechanisms responsible for the photoperiodic emergence pattern of each species. A degree of interference between the two parasites in double infections of L. peregra was evident. The presence of E. recurvatum significantly reduced the number of Plagiorchis sp. cercariae emerging in a 24 h period and also delayed the mean peak emergence time of Plagiorchissp. cercariae by 2 h. This result is consistent with the well documented antagonistic effect that the redial stages of echinostomes are known to have against the sporocysts of other digeneans within the same host mollusc.
Proteolytic activity in Caenorhabditis elegans : soluble and insoluble fractions
Authors: Gimenez-Pardo C. , Vazquez-Lopez C. , de Armas-Serra C. , Rodriguez-Caabeiro F.
Published: April 2024

Proteolytic activities of soluble and insoluble fractions of the free-living soil nematode Caenorhabditis elegans were measured across a range of substrates, temperatures and pH conditions. Several protease inhibitors were also tested under these conditions. Results of these studies indicate that proteolytic activity is present in cytosolic (CF) and non-cytosolic (NCF) fractions of C. elegans extracts at every condition of pH, temperature and buffer assayed. On the other hand, the use of different protease inhibitors demonstrated the existence of exo and endoproteases types in CF as well as NCF. Moreover our results show that the use of two protease inhibitor mixed types proposed by several authors are not enough to avoid this lytic activity when homogenates of this nematode are employed in biochemical assays.
Biotic and abiotic factors influencing growth rate and production of traps by the nematode-trapping fungus Duddingtonia flagrans when induced by Cooperia oncophora larvae
Authors: Grønvold J. , Wolstrup J. , Nansen P. , Larsen M. , Henriksen S.A. , Bjørn H. , Kirchheiner K. , Lassen K. , Rawat H. , Kristiansen H.L.
Published: April 2024

A series of experiments on corn meal agar was carried out to evaluate the efficacy of the nematode-trapping fungus Duddingtonia flagrans in different abiotic and biotic conditions which occur in cow pats. Above a concentration of 50 parasitic larvae (L3) cm–2 the fungus produced a maximum of between 500 and 600 nets cm–2 at 20°C in 2 days on the surface of corn meal agar. There were no differences in the trap-producing capacity of three strains of D. flagrans (CIII4, CI3 and Trol A). On agar at 30° and 20°C, the fungus responded to Cooperia oncophora L3 very quickly producing a maximum of trapping nets 1 day after induction. At 10°C, traps were produced slowly starting on day 4 after induction and continued over the following week. Duddingtonia flagrans (CI3) grew at a normal rate at least down to an oxygen concentration of 6 vol.% O2, but it did not grow anaerobically. On agar, D. flagrans (CI3) did not produce trapping nets in an anaerobic atmosphere. Moreover, C. oncophora L3 stopped migration under anaerobic conditions. When the fungal cultures were transferred to a normal aerobic atmosphere, after 1 and 2 weeks under anaerobic conditions, the C. oncophora L3 resumed migrating on the agar and, in response, D. flagrans produced traps in the same amount as when it had not been under anaerobic stress. Under microaerophilic conditions (6 vol.% O2) D. flagrans was able to grow, but the C. oncophora L3 were not able to induce trapping nets in D. flagrans (Trol A) because of larval immobility. But, as under anaerobic conditions, the fungus could return to a nematode-trapping state when transferred to a normal aerobic atmosphere within 1 or 2 weeks if migrating nematodes were present. Under natural conditions in the cow pat it is expected that the fungus will be ready to attack parasitic larvae, when the oxygen tension increases as a result of, for example the activity of the coprophilic fauna. Artificial light giving 3000–3400 Lux on the surface of the agar significantly depressed the growth rate and the production of trapping nets in D. flagrans (CI3). On agar, D. flagrans (CI3) could grow and produce trapping nets at pH levels of 6.3 to 9.3. Net-production has its optimum between pH 7 and 8. On dry faeces mycelial growth was 7–10 mm during a 15 day period while on moist faeces the fungus expanded 15–20 mm during the same period. Based on the parameters investigated, D. flagrans is expected to be especially active in the well aerated surface layer of a cow pat, an area which normally contains a high concentration of infective nematode parasite larvae, but also an area where the temperature can be high and the water content low.
The influence of second intermediate host species on the infectivity of metacercarial cysts of Echinoparyphium recurvatum
Authors: McCarthy A.M.
Published: April 2024

The potential influence of second intermediate host species on the infectivity of metacercarial cysts of Echinoparyphium recurvatum to the definitive host Anas platyrhynchos was examined experimentally. Echinoparyphium recurvatum metacercarial cysts were obtained from the following experimentally infected second intermediate hosts 14 days post expsoure to cercariae: Lymnaea peregra; Physa fontinalis; L. stagnalis;Planorbis planorbis; Biomphalaria glabrata; tadpoles of the amphibian Rana temporaria. Metacercarial cysts from each of these hosts were fed, in doses of 50 cysts per individual, to separate groups composed of between four and eight, 3-day-old A. platyrhynchos ducklings. All A. platyrhynchos were necropsied 15 days post-infection and the number, size, and reproductive status of E. recurvatum worms in the intestine was recorded. Analyses of variance on the number (transformed log (x + 1)) and size of worms revealed no significant differences in worms originating from metacercariae formed in the different second intermediate hosts (worm number P > 0.05, and worm size P > 0.05). All worms recovered were found to be gravid. It is therefore concluded that the species of second intermediate host utilized does not influence the infectivity of the metacercarial cyst of E. recurvatum, nor the subsequent establishment and reproductive status of the parasite in A. platyrhynchos.
Scanning electron microscopical studies on the tegument of adult worms of Schistosoma mansoni originating from ultraviolet-irradiated and non-irradiated cercariae
Authors: Mohamed S.H.
Published: April 2024

The surface topography and ultrastructural changes of Schistosoma mansoni worms developed from ultraviolet-irradiated cercariae were compared with those from non-irradiated cercariae. The tegument of worms developed from irradiated cercariae showed a variety of changes including the occurrence of oedemata and most of the tubercles being torn at the tip and having lost their spines on the dorsal surface of some male worms. In females, parts of the tegument were devoid of spines and surface lesions were present. The range and extent of these changes differed not only among individual worms but also between different regions of individual worms resulting in generalized deformities in those worms originating from irradiated cercariae.
Effects of a protein-free diet on worm recovery, growth, and distribution of Echinostoma caproni in ICR mice
Authors: Rosario C. , Fried B.
Published: April 2024

The effects of a protein-free diet on the host–parasite relationship of Echinostoma caproni in ICR mice were studied. The experimental diet was a customized protein-free diet (PFD) in pellet form containing 0% protein. The control diet consisted of a standard laboratory diet containing 23% casein as a source of protein. A total of 24 mice were each infected with 15 metacercarial cysts of E. caproni. Twelve mice were placed on the experimental diet (experimentals) and the remaining mice (controls) were placed on the control diet. Experimental and control mice were necropsied at 2, 3, and 4 weeks postinfection (p.i.). The weight of mice on the PFD was markedly lower than that of mice on the control diet. The length and circumference of the small intestine of infected mice on the PFD were significantly lower than those of the controls at 3 weeks p.i. (Student's t-test; P < 0.05). Worm recoveries from mice on the PFD were significantly lower than those of the controls at 3 weeks p.i. There was a significant decline in worm body area in worms from the mice on the PFD compared with those on the control diet at 2, 3, and 4 weeks p.i. Worm dry weights from mice on the PFD were significantly lower than those on the control diet at 2 weeks p.i. Worms from hosts on the PFD were located more posteriad in the gut than those recovered from mice on the control diet. The findings suggest that the PFD contributes to growth retardation of E. caproni in ICR mice.
Recognition of deglycosylated larval proteins of Gnathostoma spinigerum by a monoclonal antibody and human gnathostomiasis antiserum
Authors: Uparanukraw P. , Harnnoi T. , Dantrakool A. , Morakote N. , Chaicumpa W.
Published: April 2024

The study on the recognition of 35S-labelled somatic antigens of Gnathostoma spinigerum advanced third-stage larva (aL3) has revealed that the mAb GN6/24 immunoprecipitated 26- and 24-kDa proteins from the undigested and N-glycosidase F-digested larval extracts, respectively. The recognition of the deglycosylated form of the glycoprotein indicated that the mAb reacted with the peptide epitope on the 26-kDa protein. Human gnathostomiasis antiserum immunoprecipitated most of the N-glycosidase F-digested larval proteins including the deglycosylated 26-kDa protein.
The effect of excess dietary manganese on uninfected and Ascaridia galli infected chicks
Authors: Gabrashanska M. , Tepavitcharova S. , Balarew C. , Galvez-Morros M.M. , Arambarri P.
Published: April 2024

The effect of dietary manganese from two different sources on chicks (uninfected and infected with Ascaridia galli) was studied. Chick diet was supplemented with 0.9 g Mn2+ kg-1 food either in the form of MnSO4.H2O or 2Gly. MnCl2.2H2O for 20 days. Chicks were divided into six groups: group 0, control; group 1, control + MnSO4.H2O; group 2, control + 2Gly.MnCl2.2H2O; group 3, infected with A. galli; group 4, infected with A. galli + MnSO4.H2O; and group 5, infected with A. galli + 2Gly.MnCl2.2H2O. Body weight, mortality, worm burden, and liver manganese content were investigated. Excess dietary manganese increased weights and manganese level, but mortality and worm burden were unaffected. A greater bioavailability of manganese from 2Gly. MnCl2.2H2O was established.
The effect of transportation and confinement stress on egg production by Dicrocoelium dendriticum in sheep
Authors: Sotiraki S.T. , Leontides L.S. , Himonas C.A.
Published: April 2024

The effect of transportation and confinement stress on Dicrocoelium dendriticum egg production was investigated. Sheep passing a minimum of 200 eggs g-1 of faeces were selected from a naturally infected flock. A group of six ewes (group A) was transferred to the laboratory premises and kept indoors for 28 days, while another group (B) of six ewes remained on pasture and was used as a control. Faecal examinations and egg counting were performed weekly, on all sheep, from one week before to 28 days after the transportation of the animals. Comparison of faecal egg counts between groups revealed higher (P < 0.01) counts in transported sheep sampled on days 7, 14 and 28 of the trial. Furthermore, egg counts obtained from sheep that were transferred remained consistently high while the ones from sheep that remained on pasture showed significant variation. Therefore, it is concluded that stress-inducing factors, such as transportation and confinement may enhance egg production of D. dendriticum.
Sexual development of Taenia solium in hamsters from rodent-derived cysticerci
Authors: Wang I.C. , Guo J.X. , Ma Y.X. , Chung W.C. , Lu S.C. , Fan P.C.
Published: April 2024

In order to determine whether Taenia solium can be maintained in the laboratory using rodents as definitive hosts, six nude rats, 20 immunosuppressed Mongolian gerbils and 20 immunosuppressed Syrian hamsters were each inoculated through a stomach tube with three cysticerci recovered from SCID mice. No adult worms of T. solium were found in the intestinal tract of any of these 46 rodents. In addition, five immunosuppressed Syrian hamsters were fed with the same number of cysticerci enclosed in rodent muscles from SCID mice. Two of these hamsters were found to be infected 40 days post-infection, each harbouring a sexually developed worm in the intestinal tract. Although no eggs were produced, prepatent infections may be possible if a longer time was allowed for worm development. Moreover, the maintenance of the life cycle of T. solium in the laboratory using the rodent model can be established.
Mating interactions between Schistosoma haematobium and S. mansoni
Authors: Webster B.L. , Southgate V.R. , Tchuem Tchuenté L-A.
Published: April 2024

Schistosoma haematobium and S. mansoni are two medically important schistosomes, commonly occurring sympatrically in Africa and so potentially able to infect the same human host. Experiments were designed to study the mating behaviour of these two species in mixed infections in hamsters. Analysis of the data obtained showed that both heterospecific and homospecific pairs readily form. No significant difference was seen between the two species in their ability in forming pairs, however, S. mansoni showed a greater homospecific mate preference. Analysis of the data using the Mantel-Haenszel test suggests that mating competition does occur between S. haematobium and S. mansoni, the former being the more dominant species. Both species appeared to be able to change mate, with S. haematobium showing a greater ability in taking S. mansoni females away from S. mansoni males when introduced into a pre-established S. mansoni infection highlighting the competitiveness of S. haematobium. The significance of the results is discussed in relation to the epidemiological consequences occurring in Senegal, and other areas where both species are sympatric.
An update on simulation training in rhinology: a systematic review of evidence
Authors: Brennan Laura J , Balakumar Ramkishan , Waite Seren , Bennett Warren O.
Published: April 2024

Background

Rhinological procedures demand a high degree of technical expertise and anatomical knowledge. Because of limited surgical opportunities, ethical considerations and the complexity of these procedures, simulation-based training has become increasingly important. This review aimed to evaluate the effectiveness of simulation models used in rhinology training.

Methods

Searches were conducted on PubMed, Embase, Cochrane and Google Scholar for studies conducted between July 2012 and July 2022. The Preferred Reporting Items for Systematic Reviews and Meta-Analysis (‘PRISMA’) protocol defined a final list of articles. Each validated study was assigned a level of evidence and a level of recommendation based on the Oxford Centre of Evidence-Based Medicine classification.

Results

Following exclusions, 42 articles were identified which encompassed six types of simulation models and 26 studies evaluated validity. The rhinological skills assessed included endoscopic sinus surgery (n = 28), skull base/cerebrospinal fluid leak repair (n = 14), management of epistaxis and/or sphenopalatine artery ligation (n = 8), and septoplasty and septorhinoplasty (n = 6). All studies reported the beneficial impact of their simulation models on trainee development.

Conclusion

Simulation training in rhinology is a valuable adjunct to traditional surgical education. Although evidence is of moderate quality, the findings highlight the importance of simulation-based training in rhinology training.
Audio-visual Stroop matching task with first- and second-language color words and color associates
Authors: Šaban Iva , Schmidt James R.
Published: April 2024

In the audio-visual Stroop matching task, participants compare one Stroop stimulus dimension (e.g., the color of a written word) to a second stimulus (e.g., a spoken word) and indicate whether these two stimuli match or mismatch. Slower responses on certain trials can be due to conflict which occurs between color representations (semantic conflict) or due to conflict between responses evoked by task comparisons (response conflict). The contribution of these conflicts has been investigated with color word distracters. This is the first study which explores how two types of first- and second-language words affect audio-visual matching. Native French speakers performed a bilingual Stroop matching task with intermixed French (L1) and English (L2) color words (Experiment 1) and color associates (Experiment 2) presented in congruent and incongruent colors simultaneously with spoken French color words. Participants were instructed to indicate whether the spoken word “matches” or “mismatches” the font color, while ignoring written word meaning. Interestingly, the results were similar for the critical “mismatch” trials for both French and English words. The responses were the fastest on trials in which task comparisons activate fewer response alternatives, supporting the assumption of the response conflict account.
A modular computational framework for the dynamic analyses of cable-driven parallel robots with different types of actuation including the effects of inertia, elasticity and damping of cables
Authors: Mamidi Teja Krishna , Bandyopadhyay Sandipan
Published: April 2024

Dynamic simulations of the cable-driven parallel robots (CDPRs) with cable models closer to reality can predict the motions of moving platforms more accurately than those with idealisations. Hence, the present work proposes an efficient and modular computational framework for this purpose. The primary focus is on the developments required in the context of CDPRs actuated by moving the exit points of cables while the lengths are held constant. Subsequently, the framework is extended to those cases where simultaneous changes in the lengths of cables are employed. Also, the effects due to the inertia, stiffness and damping properties of the cables undergoing 3D motions are included in their dynamic models. The efficient recursive forward dynamics algorithms from the prior works are utilised to minimise the computational effort. Finally, the efficacy of the proposed framework and the need for such an inclusive dynamic model are illustrated by applying it to different application scenarios using the spatial$4$-$4$CDPR as an example.
Assessing Public Reason Approaches to Conscientious Objection in Healthcare
Authors: McConnell Doug
Published: April 2024

Sometimes healthcare professionals conscientiously refuse to treat patients despite the patient requesting legal, medically indicated treatments within the professionals’ remit. Recently, there has been a proliferation of views using the concept of public reason to specify which conscientious refusals of treatment should be accommodated. Four such views are critically assessed, namely, those of Robert Card, Massimo Reichlin, David Scott, and Doug McConnell. This paper argues that McConnell’s view has advantages over the other approaches because it combines the requirement that healthcare professionals publicly justify the grounds of their conscientious refusals of treatment with the requirement that those grounds align with minimally decent healthcare. This relatively restrictive approach accommodates conscientious refusals from minimally decent healthcare professionals while still protecting good healthcare, the independence of the healthcare professions, and the fiduciary relationships.
Innovation in surgical treatment of hypertrophic obstructive cardiomyopathy in children
Authors: Wang Zhangwei , Ma Kai , Zhu Yaobin , Li Shoujun
Published: April 2024

Hypertrophic cardiomyopathy is the second most common cardiomyopathy affecting children and adolescents and is the main cause of sudden death of young athletes. The natural prognosis of children with severe hypertrophic obstructive cardiomyopathy is not optimistic, and it is not uncommon for children with hypertrophic obstructive cardiomyopathy who do not respond to medication. Surgical treatment is often the only solution. Conventional surgical methods in the past include classic or modified extended Morrow operation, classic or modified Konno operation, and Ross-Konno operation. In recent years, with the development of minimally invasive surgery, various minimally invasive surgical methods have emerged endlessly. Because the incision of minimally invasive cardiac surgery is significantly smaller than that of traditional surgery, it causes less trauma, recovers quickly after surgery, and has the advantage of no difference in surgical effect compared with traditional median sternotomy. Tally endoscopic transmitral myectomy, RTM, minimally right thoracotomy, and other surgical methods have achieved encouraging results in adults and some older children with hypertrophic obstructive cardiomyopathy. The appearance of transapical beating-heart septectomy has brought the treatment of hypertrophic obstructive cardiomyopathy from the era of cardiopulmonary bypass and cardiac arrest to a new era of minimally invasive beating-heart surgery. In the past, there were few articles about the treatment of children with hypertrophic obstructive cardiomyopathy. This article reviewed the new progress and prognosis of surgical treatment of children with hypertrophic obstructive cardiomyopathy at home and abroad.
Immune control in Kawasaki disease knowledge mapping: a bibliometric analysis
Authors: Zhang Lu , Shi Lifeng , Zhang Ruijie , Lin Xinao , Bao Yunlei , Jiang Feng , Wu Chuyan , Wang Jimei
Published: April 2024

Background:

Kawasaki disease is a systemic vascular disease with an unclear pathophysiology that primarily affects children under the age of five. Research on immune control in Kawasaki disease has been gaining attention. This study aims to apply a bibliometric analysis to examine the present and future directions of immune control in Kawasaki disease.

Methods:

By utilizing the themes “Kawasaki disease,” “Kawasaki syndrome,” and “immune control,” the Web of Science Core Collection database was searched for publications on immune control in Kawasaki disease. This bibliometric analysis was carried out using VOSviewers, CiteSpace, and the R package “bibliometrix.”

Results:

In total, 294 studies on immune control in Kawasaki disease were published in Web of Science Core Collection. The three most significant institutions were Chang Gung University, the University of California San Diego, and Kaohsiung Chang Gung Memorial Hospital. China, the United States, and Japan were the three most important countries. In this research field, Clinical and Experimental Immunology was the top-referred journal, while the New England Journal of Medicine was the most co-cited journal. The Web of Science Core Collection document by McCrindle BW et al. published in 2017 was the most cited reference. Additionally, the author keywords concentrated on “COVID-19,” “SARS-CoV-2,” and “multisystem inflammatory syndrome in children” in recent years.

Conclusion:

The research trends and advancements in immune control in Kawasaki disease are thoroughly summarised in this bibliometric analysis, which is the first to do so. The data indicate recent research frontiers and hot directions, making it easier for researchers to study the immune control of Kawasaki disease.
Predictive value of red cell distribution width in children with pulmonary arterial hypertension associated with CHD
Authors: El Amrousy Doaa , Hashem Mona , Hassan Hassnaa , Hodeib Hossam , Elmeazawy Rehab
Published: April 2024

Background:

Pulmonary arterial hypertension, a common consequence of untreated CHD, is associated with a significant morbidity and mortality. Recent researches have demonstrated that patients with clinically severe cardiovascular illnesses, including pulmonary hypertension, have a greater mortality risk when their red cell distribution width is high. This work aimed to assess the predictive value of red cell distribution width in children with pulmonary arterial hypertension-CHD and to correlate red cell distribution width with various clinical and echocardiographic data.

Subjects and methods:

Sixty patients with CHD associated with pulmonary arterial hypertension were enrolled as the patient group. Another 60 patients with CHD and no pulmonary arterial hypertension, matched for age and sex, were enrolled as the control group. Electrocardiography and echocardiographic evaluation were performed for all included children. Red cell distribution width as part of the complete blood count was also performed using a Coulter® LH 700 series haematology analyzer.

Results:

The red cell distribution width was significantly higher in the pulmonary arterial hypertension-CHD group than in the CHD-only group (P < 0.05). There was a significant positive correlation between the red cell distribution width and mean pulmonary artery pressure. Red cell distribution width was an independent predictor of mortality in children with pulmonary arterial hypertension-CHD. The best red cell distribution width cut-off for predicting mortality in children with pulmonary arterial hypertension-CHD was ≥ 17.6%.

Conclusion:

Red cell distribution width was significantly higher in children with pulmonary arterial hypertension–CHD than in those without pulmonary arterial hypertension. Moreover, red cell distribution width could be a cheap easy predictive marker for mortality in children with pulmonary arterial hypertension-CHD.
Fear and Loathing: ChatGPT in the Political Science Classroom
Authors: Ardoin Phillip J. , Hicks William D.
Published: April 2024

ChatGPT has captured the attention of the academic world with its remarkable ability to write, summarize, and even pass rigorous exams. This article summarizes the primary concerns that political science faculty have about ChatGPT and similar AI software with regard to academia. We discuss results of a national survey of political scientists that we conducted in March 2023 to assess faculty attitudes toward ChatGPT and their strategies for effectively engaging with it in the classroom. We present several assignment ideas that limit the potential for cheating with ChatGPT—a primary concern of faculty—and describe ways to incorporate ChatGPT into faculty teaching. Several suggestions for syllabi that address political science students’ use of ChatGPT also are provided.
Household debt and economic growth in Europe
Authors: Barbaglia L. , Manzan S. , Tosetti E.
Published: April 2024

We investigate the role and impact of household debt on the economic performance of European economies during the double-dip recession of 2008–2013. We use a loan-level data set of millions of residential mortgages originated between 2000 and 2013 to calculate regional indicators of household debt. The granular information allows us to construct a measure of interest rate mispricing during the housing boom that we use to identify the effect of a credit shock (CS) on household debt. Our analysis provides three main conclusions. First, in the period 2004–2006, the measure of CS was negative in most European regions which indicates that credit conditions were significantly relaxed relative to earlier years. Second, we find that regions in which household leverage increased more rapidly during the 2002–2007 period experienced a more severe decline in output and employment after 2008. Third, we find that the CS had the largest effect on increasing leverage for the low-income and the middle-income households, although the leverage of the high-income households represents a more powerful predictor of the decline in economic activity.
No change in 24-h sodium intake estimated from spot urine in Norwegian adults from 2006 to 2019: the population-based Trøndelag Health Study (HUNT)
Authors: Holvik Kristin , Abel Marianne Hope , Holmen Jostein , Krokstad Steinar , Totland Torunn Holm , Meyer Haakon E
Published: April 2024

Objective:

Monitoring time trends in salt consumption is important for evaluating the impact of salt reduction initiatives on public health outcomes. There has so far not been available data to indicate if salt consumption in Norway has changed during the previous decade. We aimed to assess whether average 24-h salt intake estimated from spot urine samples in the adult population of mid-Norway changed from 2006–2008 to 2017–2019 and to describe variations by sex, age and educational level.

Design:

Repeated cross-sectional studies.

Setting:

The population-based Trøndelag Health Study (HUNT).

Participants:

In each of two consecutive waves (HUNT3: 2006–2008 and HUNT4: 2017–2019), spot urine samples were collected from 500 men and women aged 25–64 years, in addition to 250 men and women aged 70–79 years in HUNT4. Based on spot urine concentrations of Na, K and creatinine and age, sex and BMI, we estimated 24-h Na intake using the International Cooperative Study on Salt and Blood Pressure (INTERSALT) equation for the Northern European region.

Results:

Mean (95 % CI) estimated 24-h salt intakes in men were 11·1 (95 % CI 10·8, 11·3) g in HUNT3 and 10·9 (95 % CI 10·6, 11·1) g in HUNT4, P = 0·25. Corresponding values in women were 7·7 (95 % CI 7·5, 7·9) g and 7·7 (95 % CI 7·5, 7·9) g, P = 0·88. Mean estimated salt intake in HUNT4 decreased with increasing age in women, but not in men, and it did not differ significantly across educational level in either sex.

Conclusions:

Estimated 24-h salt intake in adult men and women in mid-Norway did not change from 2006–2008 to 2017–2019.
Transformative research for sustainability: characteristics, tensions, and moving forward
Authors: Horcea-Milcu Andra-Ioana , Dorresteijn Ine , Leventon Julia , Stojanovic Milutin , Lam David P.M. , Lang Daniel J. , Moriggi Angela , Raymond Christopher M. , Stålhammar Sanna , Weiser Annika , Zimmermann Silja
Published: April 2024

Technical summary

The question of how science can become a lever in achieving the Sustainable Development Goals permeates most recent sustainability research. Wide-ranging literature calling for a transformative approach has emerged in recent years. This ‘transformative turn’ is fueled by publications from fields such as sustainability science, social-ecological research, conservation science, sustainability transitions, or sustainability governance studies. However, there is a lack of a shared understanding specifically of what is meant for research to be transformative in this developing discourse around doing science differently to tackle sustainability problems. We aim to advance transformative research for sustainability. We define transformative research and outline six of its characteristics: (1) interventional nature and a theory of change focus; (2) collaborative modes of knowledge production, experimentation and learning; (3) systems thinking literacy and contextualization; (4) reflexivity, normative and inner dimensions; (5) local agency, decolonization, and reshaping power; (6) new quality criteria and rethinking impact. We highlight three tensions between transformative research and traditional paradigms of academic research: (1) process- and output-orientation; (2) accountability toward society and toward science; (3) methodologies rooted in scientific traditions and post-normal methodologies. We conclude with future directions on how academia could reconcile these tensions to support and promote transformative research.

Non-technical summary

Dominant ways of doing research are not enough to achieve the UN Sustainable Development Goals. The typical response of science to dealing with the current local and global sustainability crises is to produce and accumulate more knowledge. Transformative research seeks to couple knowledge production with co-creating change. This paper defines the transformative way of doing research to pro-actively support society's fight against pressing societal and environmental problems. We present six characteristics of transformative research. We reflect on the challenges related to implementing these characteristics in scientific practice and on how academia can play its part.

Social media summary

Sustainability transformation needs to be reflected in science, but what makes sustainability research transformative?
Oligocene‐Miocene Exhumation of the Pinaleño Metamorphic Core Complex, Southeastern Arizona: Support for Magmatism and Plate Margin Reorganization as Controls on Regional Exhumation Trends
Authors: Chapman James B. , Scoggin Shane H. , Jepson Gilby , Ricketts Jason W. , Schaen Allen J. , Trzinski Adam E.
Published: April 2024

The Pinaleño Mountains of southeastern Arizona is the eastern‐most metamorphic core complex in the southern U.S. and northern Mexican Cordillera. This study investigates the thermal history and exhumation record of the Pinaleño core complex using mica 40Ar/39Ar, apatite and zircon (U‐Th)/He, and apatite fission‐track thermochronometers. The Pinaleño Mountains experienced two periods of rapid cooling during the Cenozoic. The first period, from ca. 27 to 21 Ma, records tectonic exhumation related to the development of the core complex and extensional shear zone. This period was followed by a relatively quiescent interval from 21 to 13.5 Ma that records little to no exhumation. The second period of rapid cooling, from 13.5 to 11 Ma, records tectonic exhumation related to high‐angle normal faulting, characteristic of the Basin and Range province. The exhumation timing of the Pinaleño core complex matches previously recognized spatiotemporal trends in the southern Basin and Range province and indicates that core complex exhumation in this region started in southeastern Arizona (ca. 32–33°N) and migrated both northward and southward. These trends correlate well with the latitude and timing of subduction of the Pacific‐Farallon spreading ridge and the migration of the Mendocino (northward) and Rivera (southward) triple junctions. Spatiotemporal core complex exhumation trends also correlate well with regional magmatism associated with the mid‐Cenozoic flare‐up, including syn‐extensional intrusive rocks found in the footwalls of core complexes.
Cortico-striatal differences in the epigenome in attention-deficit/ hyperactivity disorder
Authors: Shastri Gauri G. , Sudre Gustavo , Ahn Kwangmi , Jung Benjamin , Kolachana Bhaskar , Auluck Pavan K. , Elnitski Laura , Marenco Stefano , Shaw Philip
Published: April 2024

While epigenetic modifications have been implicated in ADHD through studies of peripheral tissue, to date there has been no examination of the epigenome of the brain in the disorder. To address this gap, we mapped the methylome of the caudate nucleus and anterior cingulate cortex in post-mortem tissue from fifty-eight individuals with or without ADHD. While no single probe showed adjusted significance in differential methylation, several differentially methylated regions emerged. These regions implicated genes involved in developmental processes including neurogenesis and the differentiation of oligodendrocytes and glial cells. We demonstrate a significant association between differentially methylated genes in the caudate and genes implicated by GWAS not only in ADHD but also in autistic spectrum, obsessive compulsive and bipolar affective disorders through GWAS. Using transcriptomic data available on the same subjects, we found modest correlations between the methylation and expression of genes. In conclusion, this study of the cortico-striatal methylome points to gene and gene pathways involved in neurodevelopment, consistent with studies of common and rare genetic variation, as well as the post-mortem transcriptome in ADHD.