bluuebunny/crossref_metadata_2025 huggingface dataset:
Metadata for Learning Processes – Results of an International Interview Study
Authors: Rashid Sheikh Faisal , Goertz Lutz , Reichow Insa
Published: February 2024

This dossier is aimed at individuals involved in the development, implementation, and application of AI-supported systems in the field of education, particularly those who are dealing with metadata in this context. The insights and recommendations described in this dossier are based on interviews with five experts from the USA and UK, research on metadata standards, and our personal experiences in the context of the INVITE competition. This dossier provides an overview of the current development of learning metadata and existing standards. It shows the efforts and obstacles to introducing those metadata standards from an international perspective based on interviews with five experts in the field. Furthermore, this dossier shows the international experiences in selecting and using metadata standards and how these findings can inspire discussions in the German-speaking discourse regarding the use of metadata in education.
On Generalized Fibospinomials: Generalized Fibonacci Polynomial Spinors
Authors: Colak Ece Gulsah , Gonul Bilgin Nazmiye , Soykan Yuksel
Published: February 2024

In this paper, we introduce and investigate a new family of sequences called the generalized Fibospinomials (or the generalized Fibonacci polynomial spinors or Horadam polynomial spinors). Being particular cases, we handle with $(r,s)$-Fibonacci and $(r,s)$-Lucas polynomial spinors. After a short history on spinors and quaternions, we present Binet's formulas, generating functions and the summation formulas for these polynomials. In addition, we obtain some identities of generalized Fibonacci polynomial spinors, $(r,s)$-Fibonacci polynomial spinors and $(r,s)$-Lucas polynomial spinors. Moreover, we give some special identities such as Catalan's and Cassini's identities and we present matrices related with these polynomials.
Robotic Disassembly Platform for Disassembly of a Plug-In Hybrid Electric Vehicle Battery: A Case Study
Authors: Qu Mo , Pham Duc Truong , Altumi Faraj , Gbadebo Adeyemisi , Hartono Natalia , Jiang Kaiwen , Kerin Mairi , Lan Feiying , Micheli Marcel , Xu Shuihao , Wang Yongjing
Published: February 2024

Efficient processing of end-of-life lithium-ion batteries of electric vehicles is important and a pressing challenge for a circular economy. Regardless of whether the processing strategy is recycling, repurposing or remanufacturing, the first processing step would usually involve disassembly. As battery disassembly is a dangerous task, efforts have been made to robotise it. In this paper, a robotic disassembly platform using four industrial robots is proposed to automate the non-destructive disassembly of a plug-in hybrid electric vehicle battery pack into modules. The work was conducted as a case study to demonstrate the concept of autonomous disassembly of an electric vehicle battery pack. A two-step object localisation method based on visual information is used to overcome positional uncertainties from different sources and is validated by experiments. Also, the unscrewing system is highlighted, and its functions, such as handling untightened fasteners, loosening jammed screws, and changing the nutrunner adapters with square drives, are detailed. Furthermore, the time required for each operation is compared with that taken by human operators. Finally, the limitations of the platform are reported and future research directions are suggested.
Mindfulness in Virtual Reality Programme: A Sustainability Initiative in Curriculum Development in Adapted Vocational Training
Authors: Puente-Torre Paula , Delgado-Benito Vanesa , Rodríguez-Cano Sonia , García-Delgado Miguel Ángel
Published: February 2024

This research examines the effects of the implementation of an educational programme of mindfulness training using Virtual Reality (VR) with students in adapted vocational training. The aim of this programme is to instruct and strengthen attention and self-regulation skills in relation to the learning process, with the objective of reducing anxiety and impulsivity in students, contributing to promoting sustainability in education, as well as reducing inequalities. The development and implementation of this project was carried out in IES Teguise in Lanzarote (Spain) with 11 students with intellectual disabilities who used the Virtual Reality Mindfulness application called TRIPP for three months. The use of Virtual Reality offers immersive experiences, while mindfulness enables concentration, which directly contributes to higher academic performance. After the implementation of the programme, it is observed that the use of this emerging technology provides students with a sense of calm and well-being, which translates into improvements in their academic grades, promoting equal and quality education in line with the Sustainable Development Goals (SDGs).
Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features
Authors: Satake Daiken , Natsumeda Manabu , Satomi Kaishi , Tada Mari , Sato Taro , Okubo Noritaka , Kawabe Keita , Takahashi Haruhiko , Tsukamoto Yoshihiro , Okada Masayasu , Sano Masakazu , Iwabuchi Haruko , Shibata Nao , Imamura Masaru , Imai Chihaya , Takami Hirokazu , Ichimura Koichi , Nishikawa Ryo , Umezu Hajime , Kakita Akiyoshi , Oishi Makoto
Published: February 2024

Molecular analysis of growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, growing teratoma syndrome was suspected. A radical resection via the occipital transtentorial approach was performed, and histopathological examination revealed a teratoma with malignant features. Methylation classifier analysis confirmed the diagnosis of teratoma, and DMRT1 loss and 12p gain were identified by copy number variation analysis, potentially elucidating the cause of growth and malignant transformation of the teratoma. The patient remains in remission after intense chemoradiation treatment as a high-risk germ cell tumor.
Strategic Pathways to Decarbonization: Socio-Technical System Innovations for Green Shipping Compliance with IMO 2050 Targets
Authors: Lee Jeongmin , Sim Minseop , Kim Yulseong , Lee Changhee
Published: February 2024

Abstract: This study investigates the transition to sustainable shipping industry within the framework of the IMO's 2050 carbon neutrality objective, focusing on socio-technical systems analysis. The research delves into the sustainable paradigm shift towards alternative marine fuels such as LNG, methanol, ammonia, and hydrogen from a socio-technical transition perspective, analyzing the multi-level per-spective challenges and opportunities. Specifically, it scrutinizes the implications of adopting these al-ternative fuels for global shipping, identifying technical uncertainties, financial constraints, and infra-structure needs. Through a comprehensive review of existing literature on ship emissions and alterna-tive fuels, coupled with socio-technical transition theory, the study addresses the multifaceted chal-lenges and opportunities in meeting the IMO's environmental objectives. It emphasizes the necessity of collaborative governance, innovative niche strategies, and a holistic approach to leverage the current window of opportunity in facilitating the maritime industry's transition to sustainable fuel options. Fi-nally, this research enhances our understanding of the intricate interplay between technological, social, industrial, and cultural dynamics in the greening of shipping and offers insights into the strategic adop-tion of environmentally friendly marine fuels for a sustainable future.
Measurement and the Illusion of Quantum Collapse
Authors: Ring David
Published: February 2024

Models of quantum measurements are presented, including observers subject to the laws of quantum mechanics. Observers perform multiple measurements in an attempt to disprove the collapse hypothesis. It is shown that under reasonable assumptions the effort cannot succeed. Under a unitary evolution the end state is a correlation between the result of the first measurement and the result(s) of the others, consistent with the observer's collapse hypothesis. The observer may conclude that the laws of nature include a non-unitary collapse mechanism, even if one does not actually exist. Discard of information is the crucial factor which distinguishes entanglement from measurement.
ISM: A New Space-Learning Model for Heterogenous Multi-view Data Reduction, Visualization and Clustering
Authors: Fogel Paul , Boldina Galina , Augé Franck , Geissler Christophe , Luta George
Published: February 2024

We describe a new approach for integrating multiple views of data into a common latent space using non-negative tensor factorization (NTF). This approach, which we refer to as the "Integrated Sources Model" (ISM), consists of two main steps: embedding and analysis. In the embedding step, each view is transformed into a matrix with common non-negative components. In the analysis step, the transformed views are combined into a tensor and decomposed using NTF. Noteworthy, ISM can be extended to process multi-view data sets with missing views. We illustrate the new approach using two examples: the UCI digit dataset and a public cell type gene signatures dataset, to show that multi-view clustering of digits or marker genes by their respective cell type is better achieved with ISM than with other latent space approaches. We also show how the non-negativity and sparsity of the ISM model components enable straightforward interpretations, in contrast to latent factors of mixed signs. Finally, we present potential applications to single-cell multi-omics and spatial mapping, including spatial imaging and spatial transcriptomics, and computational biology, which are currently under evaluation. ISM relies on state-of-the-art algorithms invoked via a simple workflow implemented in a Jupyter Python notebook.
Pyridoxal 5′-Phosphate Biosynthesis by Pyridox-(Am)-Ine 5′-Phosphate Oxidase: Species Specific Features
Authors: Rivero Maribel , Novo Nerea , Medina Milagros
Published: February 2024

Enzymes reliant on pyridoxal 5'-phosphate (PLP), the metabolically active form of vitamin B6, hold significant importance in both biology and medicine. They facilitate various biochemical reactions, particularly in amino acid and neurotransmitter metabolisms. Vitamin B6 is absorbed by organisms in its non-phosphorylated form and phosphorylated within cells by pyridoxal kinase (PLK) and pyridox-(am)-ine 5'-phosphate oxidase (PNPOx). The flavin mononucleotide dependent PNPOx enzyme converts pyridoxine 5'-phosphate and pyridoxamine 5'-phosphate into PLP. PNPOx is vital for both biosynthesis and salvage pathways in organisms producing B6 vitamers. However, for those depending on vitamin B6 as nutrient, PNPOx participates only in the salvage pathway. Transferring PLP produced by PNPOx to client apo-enzymes is indispensable for their catalytic function, proper folding and targeting to specific organelles. PNPOx activity deficiencies due to inborn errors lead to severe neurological pathologies, particularly neonatal epileptic encephalopathy. PNPOx enzymes from different organisms maintain PLP homeostasis through highly regulated mechanisms, including structural alterations throughout the catalytic cycle and allosteric PLP binding influencing substrate transformation at the active site. Despite shared features, species-specific regulations are evident among PNPOx enzymes.
Estrus Cycle, Pyometra, and Insulin-Resistant Diabetes in the Bitch: What is Known and Why it is Relevant?
Authors: Pöppl Álan Gomes , Lopes José Lucas Xavier , Nogueira Taís Bock , Da Silva Denise Iparraguirre , Machado Bruna dos Santos
Published: February 2024

Correlations among estrus cycle, pyometra, and canine diabetes mellitus (CDM) have been described since the late 1950s, and substantial progress in understanding mechanisms beyond was achieved nowadays. Progesterone-related diabetes mellitus (PRDM) in dogs is known for its particular potential for diabetes remission. Thus, a deep understanding of the physiopathological aspects involved is crucial to postulate treatment guidelines to improve the PRDM remission rate, as well as to inform preventive measures. This narrative review aims to provide relevant detailed information on 1) canine estrus cycle and its impact on CDM etiology and management, 2) the role of pyometra as a further cause of insulin resistance, and 3) useful individual therapeutic and preventive strategies. Pharmacological annulment of progesterone effects, as well as inflammatory and progesterone-related conditions resolution in association with adequate exogenous insulin therapy, and residual beta cell function, are key aspects to achieve remission, or at least to improve diabetic clinical control. In this way, spaying should be considered mandatory in most PRDM cases. Preventive measures against CDM can include spaying recommendations; however, individual-based recommendations should be considered since castration may be associated with some long-term health issues.
Comparison of Optogalvanic and Laser-Induced Fluorescence Spectroscopy
Authors: Windholz Laurentius
Published: February 2024

Within the spectra of lanthanide atoms quite often overlapping spectral lines (blends) are observed. On the example of complicated blend situations within Pr I and La I it is shown that in such cases a combination of optogalvanic and laser-induced fluorescence detection is necessary to find all transitions contributing to the observed spectral signature.
An Equiatomic 20-Element High Entropy Amorphous Alloy: Ab Initio Molecular Dynamics Investigations
Authors: Fang Changming , Cantor Brian
Published: February 2024

Sustainable development of our society demands recycling of metallic wastes which may contain a variety of metallic impurities. Thus, it is desirable to develop a ‘universal’ structure, such as an amorphous alloy tolerating high concentrations of metallic pollutants. We performed ab initio molecular dynamics simulations to manufacture a novel multicomponent amorphous alloy of twenty elements (20e-HEAA). Analysis reveals both topological and chemical compositional short-range ordering in the obtained 20e-HEAA and formation of B-B clusters. Electronic structure calculations reveal the metallic nature of the amorphous alloy with its Fermi level falling in a valley in the density of states. Moreover, the Zn 3d and Cd 4d electrons exhibit a localized nature and thus, should be excluded from the valence electron concentration (VEC) analysis in the study of high-entropy alloys. The information obtained here is helpful to get insight into multicomponent high entropy materials, especially multicomponent high-entropy amorphous alloys as potential circular metals.
Planar Printed Structures Based on Matryoshka Geometries: A Review
Authors: Neto Alfredo Gomes , Silva Jefferson Costa e , Carvalho Joabson Nogueira de , Peixeiro Custódio
Published: February 2024

A review on planar printed structures that are based on Matryoshka-like geometries is presented. These structures use the well-known principle of Matryoshka dolls that are successively nested inside each other. The well-known advantages of the planar printed technology and of the meandered nested Matryoshka geometries are combined to generate miniaturized, multi-resonance and/or wideband configurations. Both metal and complementary slot structures are considered. Closed and open configurations are analyzed. The working principles are explored do get physical insight of their behavior. Low cost and single layer applications as frequency selective surfaces, filters, antennas, and sensors, in the microwave frequency region, are reviewed. Potential future research perspectives and new applications are discussed.
The Value of Autopsy in the Modern Age: Discrepancy between Clinical and Autopsy Diagnoses
Authors: Salzillo Cecilia , Basile Roberta , Cazzato Gerardo , Ingravallo Giuseppe , Marzullo Andrea
Published: February 2024

Introduction. Autopsy is a medical procedure that consists of the corpse’s examination to determine the cause of death and obtain information on pathological conditions or injuries present in the body. In recent years there has been a reduction in hospital autopsies and an increase in forensic autopsies. Material and methods. A retrospective observational study was conducted on the reports of all the 645 hospital autopsies performed at Polyclinic of Bari from 2006 to 2021.Results. Group A, 2006-2009, 174 cases were studied: 58% male, 58% adults, 55% neonatology, pulmonary disease was the cause of death in 23%, and 55% of discrepancy between clinical and autopsy diagnosis. Group B, 2010-2013, comprised 119 cases: 52% male, 46% infants, 48% neonatology, pulmonary disease was the cause of death in 25%, and 56% of discrepancy between clinical and autopsy diagnosis. Group C, 2014-2017, comprised 168 cases: gender equality, 37% infants, 25% gynecology, pulmonary disease was the cause of death in 24%, and 58% of discrepancy between clinical and autopsy diagnosis. Group D, 2018-2021 comprised 184 cases: 56% male, 38% adult, 32% gynecology, pulmonary disease was the cause of death in 27%, and 58% discrepancy between clinical and autopsy diagnosis.Conclusion. The study of hospital autopsies at the Polyclinic of Bari shows that the discrepancy between clinical and autopsy diagnosis is around 56.75%. Thus, the hospital autopsy is helpful in the modern age, especially for diagnosing fetal and neonatal diseases.
Acinetobacter baumannii, a Multidrug-Resistant Opportunistic Pathogen in New Habitats: A Systematic Review
Authors: Ahuatzin-Flores Omar E. , Torres Eduardo , Chávez-Bravo Edith
Published: February 2024

In recent years, humanity has faced a growing challenge posed by the rise of antibiotic-resistant bacteria, resulting in an alarming surge in fatalities and the emergence of increasingly hard-to-manage diseases. Among these resilient pathogens is Acinetobacter baumannii, due to its escalating prevalence in hospitals, elevated mortality rates, and resistance to treatment. Despite its clinical significance, our understanding of this pathogen in non-hospital settings and its virulence factors remains limited. Therefore, this review aims to shed light on the latest research regarding its ecological niche, microbiological traits, and antibiotic resistance profiles. Recent investigations have expanded its detection to various environmental niches, including rivers, treatment plants, and soils. Moreover, this bacterium has been discovered in diverse food sources such as meat and vegetables, as well as in farm animals and household pets like dogs and cats. This broader presence of Acinetobacter baumannii outside of hospital environments underscores a significant risk of environmental contamination, necessitating heightened awareness and preventive measures to address potential public health implications.
Incident Cancer Risk in Patients With Incident Type 2 Diabetes Mellitus in Hungary (Part 1)
Authors: Abonyi-Tóth Zsolt , Rokszin György , Fábián Ibolya , Kiss Zoltán , Jermendy György , Kempler Péter , Lengyel Csaba , Wittmann István , Molnár Gergő A. , Sütő Gábor
Published: February 2024

(1) Background: Patients with type 2 diabetes mellitus (T2DM) are at higher risk of cancer but how these two diseases associate is still debated. The goal was the assessment of the overall incidence of cancer among patients with newly diagnosed T2DM in Hungary. Summarizing, incident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months. (2) Methods: A nationwide, retrospective, longitudinal study was performed using a Hungarian database. The incident T2DM and diabetes free Hungarian population were included in the study. The primary endpoints were the overall and site-specific incidence and annual percentage change of the incidence of cancer in both populations. (3) Results: The overall incidence of cancer in patients amounted to 29.4/1000 and 6.6/1000 with or without T2DM, respectively, and the OR (95%CI) of cancer of the T2DM group was 4.32 (4.14-4.53), p<0.0001. The risk of having cancer was age-dependent, having the highest odd in the age group 18-39. The incidence of cancer was declining in the non-diabetic but was unchanged in T2DM population. The average lag time of diagnosing a cancer after the detection of T2DM was 3.86 months.; (4) Conclusions: Iincident T2DM is associated with a significantly higher overall risk of incident cancer, with a reverse correlation of age. Newly registered T2DM patients were suggested to be screened for cancer within 6 months.
Assessment of Radiation Tolerance of Flash Memory by γ-Ray Irradiation
Authors: Takakura Kenichiro ,   Editorial Office, Matsumoto Kensuke , Tateishi Kousei , Yoneoka Masashi , Tsunoda Isao , Suzuki Shigekazu , Kawatsuma Shinji
Published: February 2024

The radiation tolerance of a microcontroller (Raspberry Pi) required for the development of decommissioning robots was investigated. We found that the flash memory needed to boot the microcontroller had particularly low-radiation tolerance, significantly reducing the operation duration of the microcontroller in a radiation environment. We also found that certain high-performance flash memories have high radiation tolerance. Investigation of the process by which flash memory becomes inoperable revealed that internal memory information is rewritten owing to irradiation, leading to limited lifetime for memory.
Plan de negocios para la constitución de una empresa de asesoría digital para y micro y pequeña empresa
Authors:   , Salazar Moreno Erick Ivan
Published: February 2024

ISM Digital Chance (E.I.R.L.) con un accionista o inversionista, busca atender a las empresas de las zonas interdistritales norte y sur de Lima Metropolitana ofreciéndole los servicios de asesorías para que logren transformar sus empresas de manera digital, adaptándola a la nueva forma de comunicación que tengan estas para ofrecer sus productos o servicios o dar a conocer su marca, en la actualidad las limitaciones que se han dado por la pandemia ha hecho que los empresarios limiten su manera de llegar a sus clientes, es así que las empresas tienen que buscar la manera más eficiente de llegar a los clientes y nosotros les ofrecemos las herramientas y conocimientos para que se adapten este mundo cada vez más digitalizado, digitalizar las empresas y darles fuerza en las plataformas digitales será la forma de que estas se sostengan en el tiempo y puedan ser rentables. ISM Digital Chance (E.I.R.L.) ofrece servicios de asesorías basados en la creación y/o mejora de páginas web, optimización en buscadores, manejo y creación de contenido para redes sociales entre nuestras principales actividades que se realizaran a lo largo del contrato y desarrollarlas en las empresas. Contar con 3 paquetes con distintos precios para ofrecer a las empresas, nos permite llegar a una cantidad mayor de empresas con distintos presupuestos para invertir, cada empresa tiene necesidades distintas y se aplicara planes y actividades adecuados a cada empresa…
Plan de negocio para la implementación de un hotel spa para mascotas en el ámbito de Lima Moderna
Authors:   , Quispe Yance Rudiel , Carbajal Tasayco Carlos Alfredo , Gomez Álvarez Juan Manuel , Bardales Vásquez Danny Fiorella , Becerra Cavana Janeth
Published: February 2024

El presente proyecto, en su desarrollo, se enfoca en aquellos residentes de lima moderna que tienen mascotas y necesitan de un lugar seguro, confiable y profesional para alojar a sus mascotas durante sus ausencias por viajes o trabajo, en este contexto busca demostrar factibilidad en su modelo de ingresos con el fin de hacerlo rentable como negocio y oportunidad de inversión. El plan de negocio se planteó viendo la oportunidad de ofrecer un servicio de Hotel Spa para mascotas (perros) como negocio principal. En Lima Moderna ya existen negocios que brindan servicios para mascotas como; Veterinarias, SPA, adiestramiento, etc. Este proyecto de negocio se orienta en el servicio de hospedaje y SPA para mascotas con nombre comercial “Patitas felices”, para enfocarse en lo principal al servicio de alojamiento de canes, buscando eficiencia y efectividad nuestras operaciones y recursos se concentran en las actividades directas como el core principal del negocio, tendremos otros servicios relacionados manejados por terceros con el fin generar ingresos adicionales sin distraer recursos propios del núcleo principal de nuestro negocio. Según estudio de mercado se determinó la demanda y mercado potencial para llevar a cabo el plan de negocio, los estudios fueron desarrollados en 2 dimensiones dada la coyuntura actual; se desarrollaron entrevistas de profundidad y encuestas virtuales donde los datos obtenidos fueron claves para determinar la demanda y de este modo determinar un correcto plan de plan de marketing, respaldado en estrategias de marketing, financiero, y operaciones que sean saludables y sostenibles. Luego de un análisis a detalle de los indicadores e índices financieros respaldados en los estudios de mercado y costos fijos y variables que asumimos como negocio, basados en estos datos proyectamos los cálculos de VAN y TIR además de los puntos de equilibrio, datos confiables que demuestran la factibilidad del proyecto.
Evaluación estacional de la población del "Caracol plomo" Thaisella chocolata (Duclos, 1832) (Mollusca, Gastropoda) en Isla Pachacamac
Authors:   , Castañeda Farro Brisaida María Alejandra
Published: February 2024

Thaisella chocolata es un molusco gasterópodo de gran importancia económica para los pescadores artesanales; sin embargo, la información que tenemos sobre esta especie es muy limitada. El presente estudio se hizo con el fin de contribuir con la información necesaria para llevar a cabo futuros planes de manejo sostenible para esta especie. Este se realizó en Isla Pachacamac en los meses agosto y noviembre 2018 y marzo 2019, seleccionando siete estaciones de muestreo y considerando profundidades de 5, 10 y 15 m. Se evaluaron diversos parámetros poblacionales de esta especie como densidad (ind/m2), talla (mm), peso (g); relaciones talla -peso, profundidad – talla, proporción sexual y madurez gonadal. Se registró mayor densidad poblacional en noviembre 2018. La densidad incrementó a medida que aumentó la profundidad en los meses agosto 2018 y marzo 2019. Con respecto a las relaciones evaluadas, se observó que existe una relación positiva y directa entre el peso y la talla de T. chocolata; asimismo, se registró que la profundidad tuvo relación con la Longitud Peristomal (LP) de modo que los organismos más grandes se encontraron a mayores profundidades, lo que podría atribuirse a la disponibilidad de alimento o reproducción. Se encontraron todas las fases de madurez gonadal; no obstante, predominó la fase I (Inmaduro) seguida de la II (Madurante). El 97% de individuos se encontraron por debajo de la Talla Mínima de Extracción (TME); por lo que se sugiere reformular dicho indicador y monitorear a esta especie con miras a lograr un manejo sostenible.
Asociación entre violencia de pareja y tamizaje de cáncer de cuello uterino: análisis secundario, ENDES 2019
Authors:   , Guerrero Nuñez Gabriela Paola , Cuadros Couto Sebastián
Published: February 2024

Introducción: El acceso al tamizaje para cáncer de cérvix es una herramienta de salud pública importante, que podría verse limitada en su aplicación por factores relacionados con la violencia de pareja. Objetivos: Conocer la asociación entre violencia de pareja y tamizaje para cáncer de cuello uterino en las mujeres participantes de la ENDES 2019. Métodos: Diseño observacional, analítico, transversal mediante análisis secundario. La población está conformada por todas las mujeres que participaron de la encuesta ENDES 2019; mayores de 18 años y se excluyó a aquellas en las que se pierdan los datos de interés. Muestreo utilizado fue bietápico, equilibrado, estratificado e independiente, a nivel departamental y por área urbana y rural. Resultados: Se contó con una población total de 8660 personas. Las personas de 36 – 49 años fue el grupo predominante (50.23%), el 98.8% eran mujeres sin pareja. Según la residencia, el 78.9% vivía en área urbana y el 58.7% en costa. El 69.3% tenía un trabajo actual y el 78.1% tenía algún seguro de salud. El 38.3% refirió haber sufrido algún tipo de violencia por parte de su pareja, y el 83.34% alguna vez se realizó el tamizaje de cáncer de cuello uterino. Conclusiones: La prevalencia de tamizaje de cáncer de cuello uterino fue mayor en aquellas mujeres que han tenido algún tipo de violencia por parte de su pareja. Además, se pudo determinar asociación entre el tamizaje con el grupo etario, nivel socioeconómico, contar con seguro de salud y la región en la cual viven.
Factores crónicos socio patológicos por edad y género en trabajadores rurales de once poblados del Perú estudio multicéntrico 2016
Authors:   , Aquino Bellos Carlos Nemecio
Published: February 2024

Introducción: La salud mental es un tema primordial en nuestro medio, esto debe ser tomado en cuenta en la población laboral, sobre todo en trabajadores de zonas rurales. Por lo cual, se tuvo como objetivo determinar los factores crónicos socio-patológicos en trabajadores rurales de once poblados del Perú. Materiales y Métodos: Estudio retrospectivo multicéntrico realizado en once poblados rurales del Perú, se tomó los datos mediante encuestas realizadas por médicos durante la consulta de atención primaria. Se consultó acerca de consumo de tabaco, alcohol, padecer enfermedad crónica, depresión o ideación suicida. Resultados: Se usó encuestas de 2551 trabajadores, ajustado por el sexo y la edad se encontró que el personal de salud tenía mayores frecuencias de consumo de tabaco (RPa: 2,53; IC95%: 1,63-3,92); los obreros tenían mayor frecuencia de depresión (RPa: 1,74; IC95%: 1,22-2,47) y de los que trabajaban en minas tenían mayores frecuencias de consumo de alcohol (RPa: 2,98; IC95%: 1,94-4,58), sin embargo, ellos también tenían menos frecuencia de depresión (RPa: 0,63; IC95%: 0,43-0,95). Discusión: Dentro de las profesiones/ocupaciones más frecuentes en zonas rurales se encontró que algunas tienen mayor relación con algunos factores socio-patológicos crónicos que pueden afectar la salud mental. Esto debe ser evaluado y considerado como parte del programa de vigilancia ocupacional, ya que de no ser resueltos podrían generar presentismo e incluso repercusiones económicas.
Asociación entre síndrome metabólico y consumo metabólico según puesto de trabajo, en evaluaciones médicas periódicas realizadas en una clínica ocupacional de Chimbote de enero a setiembre - 2019
Authors:   , Casas del Ben Ana Cecilia Matilde , Castro Sotelo de Ramos Nancy Susana
Published: February 2024

Introducción: Respecto a la asociación entre Síndrome Metabólico y consumo metabólico según puesto de trabajo no se han encontrado investigaciones. Nuestro objetivo es determinar la asociación entre síndrome metabólico y consumo metabólico según puesto de trabajo. Material y Métodos: Data secundaria de evaluaciones médico ocupacionales de trabajadores de electricidad y pesca industrial, a los que se les clasificó en áreas administrativa y operativa. Es un estudio transversal analítico. Se realizó la prueba chi2 para examinar la asociación entre consumo metabólico y síndrome metabólico según puesto de trabajo. Resultados: Se analizaron datos de 944 evaluaciones médico ocupacionales, el 28,4% fueron administrativos y 71,6% Operativos. La prevalencia de SM fue de 50,6%. En el rubro electricidad el 60,8% de operativos presentó consumo metabólico moderado. En pesca industrial – planta el 50,0% de los administrativos con SM presentó consumo metabólico moderado. En pesca industrial – mar no existió diferencia significativa entre consumo metabólico ligero (60,6%) y muy elevado (58,9%) en la presentación de SM. Conclusiones: La evaluación por rubros no mostró asociación entres consumo metabólico, síndrome metabólico y puesto de trabajo.
Preparation and visible light catalytic degradation of hollow urchin-like TiO2/N-GQDs composites on waste organic dyes
Authors: Liu Gang , Xu Sheng , Li Wenting , Hui Bing
Published: February 2024

In order to enhance the visible light catalytic activity of TiO2 by broadening its photoresponse range, the TiO2/N-GQDs (TGs) composite catalysts with a three-dimensional hollow urchin-like structure were prepared by one-step hydrothermal method using potassium titanium oxalate and citric acid as raw materials. The microstructure and photoelectric properties of the synthesized TGs composites were analyzed through a series of characterizations, and the performance in degrading organic dyes under visible light was investigated. The results demonstrated that the prepared composites effectively enhanced the visible light absorption spectrum of TiO2 by forming heterojunction, and the photocatalytic degradation efficiency of TGs composites on organic dyes was significantly improved than neat TiO2. The degradation efficiency of organic dyes could reach 95.71% under visible light irradiation for 1 hour, which further increased to 99.39% after 2 hours. Additionally, the photocatalytic degradation process could be effectively accelerated under acid conditions. After 5 cycles of testing, the degradation efficiency of TGs composites on organic dyes was hardly reduced, indicating that they had great visible light catalytic activity and significant reusability.
A Novel Integration of Regret-Based Methodology and Bankruptcy Theory for Waste Load Allocation
Authors: Nouri Alireza , Namin Masoud Montazeri , Oftadeh Ershad
Published: February 2024

This article proposes a novel approach to tackle the ambiguity and limitation of the Fuzzy Risk Index in assessing the severity of river pollution based on a regret theory named River Quality Regret Index (RQRI). RQRI and total treatment cost respectively represent the conflicting objectives of environmental protection and pollutant management within the river-pollutant system. Using a multi-objective optimizer simulator model, Nash bargaining identifies the agreement from the non-dominant solutions found on the exchange curve of these objectives. To further account for the spatial distribution of pollutant discharge, a new framework, Namin rule, is developed by integrating RQRI with the bankruptcy approach for waste load allocation. Implementation of this methodology on the KhoramAbad River using quantitative and qualitative data reveals the efficacy of RQRI compared to the Fuzzy risk, particularly when pollutant sources are dispersed. Additionally, Namin rule, compared to the constrained equal awards rule, demonstrates a greater utilization of the river's self-purification capacity in such scenarios. This framework offers a robust and flexible tool for managing river pollution by balancing environmental and economic considerations.
Angiotensin 1-7 reduces lipid deposition in the renal tubules of high-fat fed mice
Authors: qin Zheng , Cui Hongqing , Zhu Huanhuan , Guo Honglei
Published: February 2024

Background
To investigate the effects of angiotensin 1–7 (Ang-(1–7)) on proximal tubules in mice fed a high-fat diet (HFD).
Methods
Mice were randomly divided into three groups, including the control group (mice fed a standard rodent chow diet), HFD group, and HFD group treated with Ang-(1–7). At the end of the experiment, 24-h urine samples and kidney specimens were collected. We evaluated proximal tubule injury with PAS. Renal Oil Red O staining and immunofluorescence staining were used to disclose the expression of lipid deposition. Endoplasmic reticulum stress, inflammation and apoptosis were tested by Western blotting.
Results
Serum creatinine, blood urea nitrogen, and urinary albumin were elevated in HFD mice, while urinary albumin was decreased after Ang-(1–7) treatment. Ang-(1–7) dramatically inhibited the development of vacuolated tubular cells and lipid deposition while decreasing the expression of perilipin-2 and CD36. Ang-(1–7) also ameliorated the increase in endoplasmic reticulum stress and apoptosis. Furthermore, increased TNF-α, MCP-1, and IL-1β levels in HFD mice were inhibited by Ang-(1–7) treatment.
Conclusions
Ang-(1–7) treatment mediated reno-protection by attenuating lipotoxicity to inhibit inflammation and endoplasmic reticulum stress-induced apoptosis in HFD mice. These findings may offer a novel therapy for HFD-related renal injury.
Re-investigation of Moment Direction in a Kitaev Material α-RuCl3
Authors: Kim Young-june , Kim Subin , Horsley Ezekiel , Nelson Christie , Ruff Jacob
Published: February 2024

We report X-ray diffraction and resonant elastic X-ray scattering (REXS) studies on two α-RuCl3 crystals with distinct magnetic transition temperatures: TN=7.3K and 6.5K. We find that the sample with TN=6.5K exhibits a high degree of structural twinning at low temperature, whereas the TN=7.3K sample primarily comprises a single domain of R¯3. Notwithstanding, both samples exhibit an identical zigzag magnetic structure, with magnetic moments pointing away from the honeycomb
plane by α = 31(2)◦.We argue that the identical ordered moment directions in these samples suggest that the intralayer magnetic Hamiltonian remains mostly unchanged regardless of TN.
Land use system effects on biodiversity of litter ants (Hymenoptera: Formicidae) in tropical rainforest, South Region of Cameroon.
Authors: tchoudjin Gertrude Loveline , Roselle Aymélé-Choungmo Syntiche , Stephanie Kakam , Patrick Kenfack-Fogang
Published: February 2024

The species diversity of ants in three different land use types: forest, old cocoa farm and palm grove were studied to determine and evaluated the effect of land-use on diversity and composition of ant species in these areas. Four sampling methods: handling capture, sugar-protein bait trap, pitfall trap and berlese, were conducted from september 2021 to october 2022. Species richness and Shannon diversity index were used to characterize diversity of ant communities. A total of 245 ant species, belonging to 37 genera and 8 subfamilies were identified. The specific richness for each area and the Shannon-Wiener’s species diversity index indicated that the diversity was the highest in the forest 192 (H’= 3.01), followed by the old cocoa farm 152 (H’= 2.88) and lastly the palm grove 94 (H’= 2,53). Thirteen (13), nine (09) and two (02) species were restricted to the forest, old cocoa farm and palm grove habitats respectively as indicator species, and showed sensitivity to environmental gradients. These attributes make them potentially useful as subjects or tools for assessing the conservation value of habitats studied. Therefore, the information from this study suggests that anthropogenic disturbances have the impact on the variation of leaf litter ant species diversity.
Preserving Information while Respecting Privacy: An Information Theoretic Framework for Synthetic Health Data Generation
Authors: Sella Nadir , Guinot Florent , Lagrange Nikita , Albou Laurent-Philippe , Desponds Jonathan , Isambert Herve
Published: February 2024

Generating synthetic data from medical records is a complex task intensified by patient privacy concerns. In recent years, multiple approaches have been reported for the generation of synthetic data, however, limited attention was given to jointly evaluate the quality and the privacy of the generated data. The quality and privacy of synthetic data stem from multivariate associations across variables, which cannot be assessed by comparing univariate distributions with the original data. Here, we introduce a novel algorithm (MIIC-SDG) for generating synthetic data from electronic records based on a multivariate information framework and Bayesian network theory. We also propose a new metric to quantitatively assess the trade-off between the quality and privacy of synthetic data generation methods. The performance of MIIC-SDG is demonstrated on two clinical datasets and favorably compares with state-of-the-art synthetic data generation methods, based on the trade-off between several quality and privacy metrics.
Multidrug-resistant phenotypes of genetically diverse Escherichia coli isolates from healthy domestic cats.
Authors: Núñez-Samudio Virginia , Pimentel-Peralta Gumercindo , Cruz Alexis De La , Landires Iván
Published: February 2024

β-lactamases-producing Escherichia coli are a widely distributed source of antimicrobial resistance (AMR), for animals and humans. Little is known about the sensitivity profile and genetic characteristics of E. coli strains isolated from domestic cats. We report a cross-sectional study that evaluated E. coli strains isolated from domestic cats in Panama. Forty-eight E. coli isolates were obtained, of which 80% presented resistance to at least one of the antibiotics analyzed, while only 20% were sensitive to all (p = 0.0001). The most common resistance was to gentamicin (58%). Twenty-nine percent were identified as multidrug-resistant isolates and 8% with extended spectrum beta-lactamase phenotype. The genes blaTEM, blaMOX, blaACC and blaEBC were detected. Plasmid-mediated resistance qnrB and qnrA are reported. The most frequent sequence types (STs) being ST399 and we reported 5 new STs. Our results suggest that in intestinal strains of E. coli isolated from domestic cats there is a high frequency of AMR.
Prevalence and genetic diversity of porcine circovirus type 2 in Henan Province of China during 2020-2023
Authors: Peng Zhifeng , Lv Huifang , Zhang Han , Zhao Li , Du Jimei , He Yanyu , Zhao Kangdi , Xu Qianqian , Qiao Hongxing , Bian Chuanzhou
Published: February 2024

The genetic diversity and widespread of porcine circovirus type 2 (PCV2), mainly lead to porcine circovirus-associated diseases (PCVADs), seriously threatens the swine industry worldwide. In the present study, to investigate the recent prevalence and genetic diversity of PCV2 in Henan Province of China, a total of 385 tissue samples collected from pig farms of different sizes during 2020 and 2023 were analyzed by PCR. Overall, 71.17% (274/385) tissue samples of pigs were positive for PCV2, with the detection rates of PCV2 were 81.16% (112/138), 72.41% (84/116), 62.50% (55/88), 53.49% (23/43) in 2020, 2021, 2022, 2023, respectively, indicating the detection rates of PCV2 decreased progressively in Henan Province of China in recent years. Additionally, the complete genomes of 34 PCV2 strains were sequenced and analyzed, which indicated that their nucleotide identities were 93.9–100.0%, 96.70–100.0%, and 88.90–100.0% in the complete genome, ORF1, ORF2, respectively, and amino acid identities were 98.10–100.0% and 88.60–100.0% in the replicase and capsid proteins, respectively. Phylogenetic analysis based on the complete genome sequences and deduced amino acids of ORF2 showed that the PCV2 strains obtained in the present study could be classified into three sub-clades, with the most strains clustered into clade PCV2d, indicated PCV2d is the predominated subtype in Henan Province, China. Moreover, four substitution sites (V57I, I89R/L, P134T, D210E) were observed in PCV2b ORF2 that were absent in PCV2a and PCV2d, and 4 substitution sites (S68N, I89L, T/P134N, S169G/R) were observed in PCV2d ORF2 that were absent in PCV2a and PCV2b. In general, the present study revealed a high prevalence and high genetic divergence of PCV2 among Chinese swine herds, provided an insight into the ongoing emerged PCV2, and enriched our understanding of the genetic diversity and evolution of PCV2.
Spatial transcriptomics reveals substantial heterogeneity in triple negative breast cancer with potential clinical implications
Authors: Wang Xiaoxiao , Venet David , Lifrange Frédéric , Larsimont Denis , Rediti Mattia , Stenbeck Linnea , Dupont Floriane , Rouas Ghizlane , Garcia Andrea Joaquin , Craciun Ligia , Buisseret Laurence , Ignatiadis Michail , Bhalla Nayanika , Masarapu Yuvarani , Villacampa Eva Gracia , Franzén Lovisa , Saarenpää Sami , Kvastad Linda , Thrane Kim , Lundeberg Joakim , Rothé Françoise , Sotiriou Christos
Published: February 2024

While triple negative breast cancer (TNBC) is known to be heterogeneous at the genomic and transcriptomic levels, spatial information on tumor organization and cell composition is still lacking. Here, we investigated TNBC tumor architecture including its microenvironment using spatial transcriptomics on a series of 92 patients. We performed an in-depth characterization of tumor and stroma organization and composition using an integrative approach combining histomorphological and spatial transcriptomics. Furthermore, a detailed molecular characterization of tertiary lymphoid structures led to identify a gene signature strongly associated to disease outcome and response to immunotherapy in several tumor types beyond TNBC. A stepwise clustering analysis identified nine TNBC ecotypes, further validated in external datasets. Several ecotypes were associated with disease outcome and characterized by potentially actionable features. This is the largest TNBC series providing a comprehensive insight into the complexity of TNBC ecosystem with potential clinical relevance, opening avenues for treatment tailoring including immunotherapy.
Comparison of Resuscitation Intervention Utilization in the Emergency Department by Palliative Care Eligible Patients Between Cancer and Non-Cancer
Authors: Wibulpolprasert Arrug , Wangviboonchai Varaporn , Saengprateeptong Pich , Chongthavonsatit Nichapha , Pongsettakul Natthakorn , Prachanukool Thidathit
Published: February 2024

Background Resuscitation interventions are procedures for managing clinical deterioration in patients with life-threatening conditions by securing the airway, maintaining breathing, or supporting circulation. Little is known about differences in the use of resuscitation interventions and the characteristics of patients eligible for palliative care in the emergency department. The objectives of this study are to compare resuscitation interventions in the emergency department between patients with cancer and non-cancer palliative care eligibility.
Methods A retrospective cohort study was conducted by reviewing the medical records of the palliative care eligible patients who visited the emergency department of one university hospital between January and June 2019.
Results Among the 956 visits (13.7%) by palliative care eligible patients of 7000 random visits, 480 were patients with cancer (50.2%), and 476 were non-cancer patients (49.8%). The overall median age was 72, and 54.1% were female. The mortality rates in the following year were 35.0% for patients with cancer and 18.7% for non-cancer illnesses. The patients with cancer and non-cancer received prior palliative care at 7.3% and 0.8% (p <0.001) and initiated palliative care at the emergency department at 6.3% and 2.7%, respectively (p = 0.008). The non-cancer patients utilized overall resuscitation interventions 1.7 times more than the cancer patients (aOR = 1.7, 95% CI = 1.0–2.6, p = 0.030).
Conclusion For the palliative care eligible patients in the emergency department, patients with cancer and non-cancer significantly differed in their characteristics. Patients with non-cancer received more resuscitation interventions than patients with cancer.