bluuebunny/crossref_metadata_2025 huggingface dataset:
Nurses' Knowledge and Practice Regarding Care of Patients Undergoing Chest Tube
Authors: E.I.E. Noura , H.M. Furat , A.A.E. Rasha
Published: June 2022

Chest tube is a postoperative therapeutic intervention widely applied to the respiratory tract and cardiothoracic care. A chest tube can be a life-saving intervention for patients with pneumothorax, effusion and hem thorax. However, it is associated with significant morbidity and mortality. Aim: To assess nurses’ knowledge and practice regarding care of patients undergoing chest tube. Design: A descriptive exploratory study design was used _Setting: Intensive Care Unit, Surgical and Operational Departments, in El-Mahalla Chest Hospital, and El-Mahalla Cardiac Center. Sample: A convenient sample of all available nurses (60 nurses )who work with patient undergoing chest tube. Tools: 1) Self-administered interview questionnaire consists of two parts part 1: Nurse’s demographic data characteristics, part 2: Nurse’s knowledge about chest tube. Tool 2) Observational checklist. Results: Findings of the present study showed that more than one third (41.7%) of the studied nurses had average knowledge regarding management of patient with chest tube drainage. While one third and less than one quarter (35% &23.3%) of them had poor and good knowledge, respectively. Moreover, nearly two-thirds (60%) of the studied nurses had incompetent practice regarding management of patient with chest tube drainage. On the other hand more than one third (40%) of them had competent practice regarding management of patient with chest tube drainage. Finally, There was a highly statistical correlation between total nurse's knowledge and their total practice regarding management of patient with chest tube drainage (P<0.01). Conclusion: the majority of the studied nurses had insufficient knowledge and practice regarding management of patient with chest tube drainage. Recommendations: 1) Development of in-service training programs to maintain efficient performance of nurses, 2) Replication of the study on a larger sample and in different geographical areas in Egypt for generalization of findings.
Health Related Quality of Life for Patients after Mitral Valve Replacement Surgery
Authors: K.S. Marwa , H.A. Zainab , I.E. Enas
Published: June 2022

Background: Mitral valve disease is becoming a public health problem due to increasing life expectancy and new treatment methods for mitral valve replacement, mitral valve replacement surgery can be a challenging and stressful life event, however, patient experiences after mitral valve replacement surgery are inadequately described. Aim of the study: The aim of this study is to assess health related quality of life for patients after mitral valve replacement surgery. Design A descriptive exploratory research design was used to achieve the aim of this study. Setting the study was carried out in the outpatient and cardiothoracic unit at Beni–Suef University Hospital. Sample A purposive sample of all available patients (N=60). Tools: Two tools were used to collect the data. I - self – administration questionnaire II world health organization quality of life SF12 assessment questionnaire. Results: less than a quarter of the studied patients had a satisfactory level of knowledge regarding mitral valve disease. Less than half of the studied patients had low quality of life level and less than a third had a high quality of life level. A statistically significant relation was found between patients’ level of knowledge job, gender, and educational level. There is no statistically significant relation found between patient's quality of life and their age, gender, marital status, gender, job, and level of education. Conclusion: It concluded that less than a quarter of the studied patient had a satisfactory level of knowledge Overall the study has indicated that, the majority of the studied patients had educational, Physical, Psychological, Social, and mental needs to improve their QOL Recommendations: Further research is recommended to carry out on larger sample to determine patient's quality of life needs.
Cardiovascular risk profile in patients with hepatic steatosis
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Peltec Angela , Ivanov Victoria ,   Institute of Cardiology, Republic of Moldova, Toaca Ines ,   Department of Internal Medicine, Clinical Institute Fundeni, Bucharest, Romania, Matcovschii Sergiu ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: June 2022

Background. Fatty liver disease (FLD) is composed of a wide spectrum including metabolic associated fatty liver disease (MAFLD). Cardiovascular disease (CVD) is the leading cause of mortality in this populational group. Many risk estimation systems are in existence for improving the management of population groups, but currently, none of the available risk prediction models are authenticated in patients with hepatic steatosis. Materials and methods. Transversal, observational, prospective, case control study has been included 680 patients with MAFLD and 96 control subjects without MAFLD. Experimental group was divided in tree subgroups: A - overweight or obesity (BMI ≥ 25 kg/m2 ) N= 498; B – lean/normal weight (BMI <25kg/m2 ) N= 58 and C – Type 2 diabetes mellitus N= 156. For each patient, cardiovascular risk was estimated using the Framingham equation (risk ≥ 20% – high), SCORE risk chat (risk ≥ 10% – high) and Atherosclerotic Cardiovascular Disease Risk Algorithm from the American College of Cardiology and the American Heart Association (AHA/ACC) (risk ≥ 20% – high). Results. Model Risk SCORE and Risk ACC/AHA had identified the low proportion of patients with high risk, however, Risk FRS determined the highest proportion of the patients as being ‘at high-risk’ (Risk SCORE -7% vs Risk ACC/AHA - 15% vs Risk FRS - 38%, p <0.001). Statistically significant correlations were found between the scoring systems Risk FRS and Risk ACC/AHA (Pearson’s r = 0.939, p = 0.0001, Spearman`s rho=0.960, p <0.001). The highest proportion of the patients as being ‘at high-risk’ from group C – DMT2 was found by model RiskFRS – 82.7%, with statistically significant difference between group A and B – 28.1 % vs 6.8%, p < 0.001. The same tendency was observed for RiskSCORE and Risk ACC/AHA (RiskSCORE DMT2 – 26.3% vs Risk ACC/AHA DMT2 – 46.8%), bur these scores have identified the low proportion of patients with high risk in this populational group. Conclusions. The study shows that RiskFRS appeared to be most useful CVD risk assessment model in hepatic steatosis, RiskFRS is likely to identify a greater number of patients at ‘high-risk’ as compared to Risk SCORE and Risk ACC/AHA.
Stroke care indicators in the Republic of Moldova – the RES-Q registry
Authors:   Nicolae Testemitanu State Uni8versity of Medicine and Pharmacy, Replublic of Moldova, Manole Elena , Tiu Cristina ,   University of Medicine and Pharmacy “Carol Davila”, Romania, Vilionskis Aleksandras ,   Vilnius University, Lithuania, Tsiskaridze Alexander ,   Ivane Javakhishvili Tbilisi State University, Georgia, Zota Eremei ,   Nicolae Testemitanu State Uni8versity of Medicine and Pharmacy, Replublic of Moldova, Grecu Andreea ,   St. Anne’s University Hospital, Brno, Czech Republic, Mikulik Robert ,   St. Anne’s University Hospital, Brno, Czech Republic, Bornstein Natan ,   Tel Aviv University, Israel, Groppa Stanislav ,   Nicolae Testemitanu State Uni8versity of Medicine and Pharmacy, Replublic of Moldova
Published: June 2022

Introduction. There were no data on in-hospital stroke care indicators until Moldova’s accession to the international Registry of Stroke Care Quality (RES-Q) platform in 2016. The aim of this paper was to assess the acute stroke care quality in Moldova based on the data of the RES-Q registry. Material and methods. We analyzed the data of all patients with acute ischemic and hemorrhagic stroke of the RES-Q from 15 Moldovan hospitals. Data were collected for one month each year, during a 3-year period (2017-2019). Data analysis was performed between hospitals according to their access to a brain CT facility for Moldovan participating hospitals. Additionally, Moldovan data were compared with other three ESO-EAST (European Stroke Organization Enhancing and Accelerating Stroke Treatment) project countries: Romania, Lithuania, and Georgia. Results. A total of 1660 patients were recruited in the study, mean age of 68 years (49% men). Moldova registered poorer results in number of brain CT performed (81% [95% CI 79-84%]), dysphagia screening (29% [95% CI 27-32%]), IV thrombolysis performed (3% [95% CI 2-4%]), administration of anticoagulants (44% [95% CI 39-49%]) and statins (42% [95% CI 39-45%]) at discharge, in-hospital stroke mortality (17% [95% CI 15- 19%]). Within Moldova the stroke care quality was driven by the access to CT scan. Conclusions. Our study highlighted some serious gaps of in-hospital stroke care performance in Moldova, such as the lack of CT scans in many public hospitals, the absence of a national stroke center network, extremely low accessibility of IV thrombolysis and unsatisfactory implementation of secondary stroke prevention treatment
Transurethral resection of lithiasis in chronic nonbacterial prostatitis
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Colța Artur , Ghicavîi Vitalii ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: June 2022

Introduction. According to specialized literature, prostatic calculi are found in up to 80% of men over the age of 50. Prostatic calculi associated with chronic prostatitis may be closely related to lower urinary tract symptoms (LUTS) and may cause nonspecific symptoms of LUTS. The treatment approaches of prostatic calculi in chronic prostatitis include drug therapy, minimally invasive as well as open surgeries, the number of which is actually decreasing worldwide. This phenomenon is mostly related to the emergence of both new diagnostic technologies and endourological treatment. Material and methods. The study included 40 patients with bladder outlet obstruction caused by prostatic calculi due to CNBP, who were diagnosed via a series of clinical and paraclinical investigations. The treatment methods to remove the bladder outlet obstruction included surgical approaches like transurethral resection (TUR) (n = 10 patients) and laser surgery (Ho: YAG) (n = 30 patients). Subsequently, the patients were monitored and monitored at 1 and 3 months. Results. All included patients in the study complained of difficulty urinating (bladder outlet obstruction and residual urine) underwent endoscopic surgical treatment. 30 patients underwent transurethral resection of the prostate with Ho:YAG laser operating at pulse energy of 2.3 J and a frequency of 18 Hz, with a peak power of 18.4 W. Laser incisions were made at 5 and 7 points of a standard quadrant by local tissue resection and removal of prostate stones. During 3 months of follow-up, the mean IPSS value improved from 23.2 ± 2.57 points to 12.6 ± 0.54 points; QoL also changed from 4.83 ± 0.51 points to 2.23 ± 0.1 points; Qmax shifted from 9.08 ± 1.8 ml/s before surgery to 14.07 ± 1.7 ml/s after surgery; the mean value of residual urine decreased to 94.8 ± 47.4 ml and 34.23 ± 9.82 ml. The other 10 patients with prostate stones due to CNBP underwent another endoscopic method: incision (ITUP) or transurethral resection (TURP). The dynamics of the test findings during the follow-up period: IPSS improved from 22.9 ± 2.42 to 10.7 ± 0.5 points; QoL improved from 5.0 ± 0.66 to 2.1 ± 0.31 points; Qmax changed from 9.34 ± 1.29 ml/s to 15.82 + 0.44 ml/s after the surgery. The average value of residual urine decreased from 92.9 ± 17.95 ml to 38.9 ± 5.97 ml. A decrease in prostate volume of 15.2 cm3 was also observed, possibly due to partial removal of sclerotic tissue and lithiasis. Conclusion. Improvement in urodynamic parameters showed that endoscopic surgical treatment of prostate stones is an effective method for eliminating bladder obstruction and helps to restore urination, as well as improving the quality of life.
Trigger impact of Chlamydia trachomatis on various types of seronegative spondyloarthritis
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Chișlari Lia , Groppa Liliana ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Russu Eugeniu ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Cazac Victor ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Rotaru Larisa ,   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova
Published: June 2022

Introduction. To date, clinical manifestations, laboratory changes and the results of instrumental examinations of the joints and spine in axial seronegative spondyloarthritis (aSpA) caused by Chlamydia trachomatis have not been fully elucidated. Purpose of the study: evaluation of clinical manifestations features, diagnosis, and evolution of seronegative spondyloarthritis associated with Chlamydia trachomatis infection. Objectives of the study: To compare clinical manifestations, changes in laboratory parameters, results of instrumental examinations of the joints and spine in seronegative spondyloarthritis, the axial, peripheral, and mixed form. To appreciate the significance of Chlamydia trachomatis in the development of SpA by detecting the presence of DNA using the polymerase chain reaction (PCR) in real time and by isothermal amplification of NASBA-PCR (Nucleic acid sequence-based amplification). Material and methods. During 2015-2021 were examined 138 patients with SpA hospitalized in the Republican Clinical Hospital „Timofei Moşneaga”. Chlamydia trachomatis in the form of monoinfection was detected in 87 (6.3%) patients, of which 52 (59.8%) were women and 35 (40.2%) men. Results. The results of the diagnosis of Chlamydia trachomatis infection in patients with arthritis: Chlamydia trachomatis infection was detected in 78 (89.7%) out of 87 patients examined by PCR, and in 9 (10.3%) cases by ELISA. The peripheral form begins mainly with inflammation of the joints of the lower extremities (81.8%), of which the knee joints are mainly involved in the pathological process (63.6%). SpA axial form associated with Chlamydia trachomatis infection occurs mainly in young men (85.7%). In more than half of the patients, large joints participate in the pathological process (58.8%), especially the lower extremities. The axial variant of the SpA can begin with an injury in any part of the spine. Discussions. SpA associated with Chlamydia trachomatis infection has more expressed clinical, laboratory and instrumental manifestations both in the onset and in the advanced stage of the disease.
Epidemiological spectrum and diagnostic management of chronic myeloid leukemia – actualization and milestones
Authors:   Nicolae Testemitanu State University of Medicine and Pharmacy, Replublic of Moldova, Musteata Vasile
Published: June 2022

Introduction: Chronic myeloid leukemia (CML) comprises 15-20% of all leukemia cases in adults, being the most common chronic myeloproliferative neoplasm, with the patients’ immunocompromised status in the advanced phases. The international periodical literature stipulates the increased susceptibility of patients with malignant tumors to SARS-CoV-2 infection, but the contagion risk is not determined in regards to the histological type of hematologic malignancies. The aim of the study was the comparative evaluation of the current epidemiological patterns and the contemporary diagnostics output in CML, axed on the optimization of tactics of diagnosis management in the context of the pandemic with COVID-19 infection. Materials and methods: An analytical, qualitative, secondary study was performed – the narrative review of literature in the form of a synthesis article. Fifty three relevant primary sources were identified and selected, according to the significance of the impact score, with the subsequent and scientific data extraction and analysis. Results: CML varies between 0.8 - 2.0 cases per 100000 population. The total number of patients diagnosed with CML increased annually by 2% during 2007-2016. In 2017, a comparatively high level of the age-standardized death rate (ASDR) (0.6 per 100,000 population, 95% IU) and the DALYs (disability-adjusted life-years) age-standardized rate (ASR) (16.71 per 100,000 population, 95% IU) were registered in quintiles with low SDI. By the quantitative RT-PCR analysis of blood cells for BCR-ABL p210 gene transcript, the published studies highlight its large variations: 21.84 - 100% IS. FISH and PCR are able to detect rare BCR-ABL gene variants and breakpoints that may go unnoticed by conventional cytogenetics. Conclusions: Despite the declining overall trend of ASIR, ASDR and age-standardized DALYs at the expense of high SDI quintiles, the CML burden remains stable due to the growing population in developing countries and the aging population in developed countries. Management of patients with primary diagnosed CML, with high risk factors, should include enhanced surveillance for SARS-CoV-2 infection. Diagnostics management of patients with CML includes morphological, cytogenetic and molecular-genetic investigations of the peripheral blood and bone marrow regardless of the phase of clinical evolution, with FISH and RT-PCR as proving resolutive modalities.
Hypertrophic cardiomyopathy: literature review and case report
Authors:   Medpark International Hospital, Republic of Moldova, Batrînac Aureliu , Slobozeanu-Russu Ala ,   Medpark International Hospital, Republic of Moldova, Belîi Natalia ,   Medpark International Hospital, Republic of Moldova
Published: June 2022

Introduction. Hypertrophic cardiomyopathy is an autosomal dominant genetic disease. The signs and symptoms of disease vary in terms of history and clinical course, ranging from the development of acute heart failure or even sudden death, while other patients may remain asymptomatic throughout life. At the same time, there is a lack of correlation between the genotype and the phenotype of the disease. Thus, within a family, of two members carrying the same genetic abnormality, one may present a clinical manifestation of severe heart failure, the other remaining asymptomatic. Clinical case presentation. In this paper, we report a case of a 34-year-old male who comes to see a cardiologist with complaints of moderate-intensity dyspnea, general weakness, and fatigue installed during the post-COVID-19 recovery period. Management and results. The evolutionary positive dynamics of the disease on the prescribed treatment is followed, as well as the diagnostic criteria for hypertrophic cardiomyopathy. Discussion. The discussed clinical case of acute cardiac failure in adult otherwise healthy mail is of interest because it rises clinical combinations that were not debated previously: primary diagnosed hypertrophic cardiomyopathy combined with COVID-19, post-COVID-19 isolated myocarditis, hypertrophic cardiomyopathy associated with myocarditis and infection COVID-19. If the suspicion of hypertrophic cardiomyopathy is confirmed, the eventual perianesthetic management of such a patient will change radically. The article presents details of the pathophysiology of hypertrophic cardiomyopathy and key elements for maintaining hemodynamic goals
Antipyretic and Anti-oxidant potential of Hydroalcoholic extract of Gendarussa vulgeris
Authors: M. Banwale Mateshwari , Chaouhan Disha , Singh Manjeet , Mujariya Rajesh , Bisen Priya
Published: June 2022

G. vulgaris Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala. Various parts of this plant have been used in the treatment of ulcers, sores, inflammation, dyspepsia, healing of wounds, etc. The present study aimed at the evaluation of anti-pyretic activity of the hydroalcoholic extracts of the leaves by in vivo methods. Phytochemical screening reveals the presences of Alkaloids, Saponins, Carbohydrates, Flavonoids and Phenols. The total phenolic content was found 0.691mg/100mg of dry weight of extract, expressed as gallic acid equivalents and the total flavonoid content was found 0.847mg/100mg, expressed as Quercetin equivalents. Antioxidant activity was performed using DPPH method. The IC50 value of Hydroalcoholic extract of Gendarussa vulgaris was found to be 55.79µg/ml. Yeast induced pyrxia and anti-pyretic property of hydroalcoholic extract of leaves of Gendarussa vulgaris. The effect of hydroalcoholic extract of leaves of Gendarussa vulgaris were determined after administration at two dose levels (100 and 200 mg/kg b.w.) in yeast induced pyrxia rats. From the results, it may be concluded that hydroalcoholic extract of leaves of Gendarussa vulgaris possess significant anti-pyretic effect may be due to the effect of antioxidants and constituent present in the leaves.
Mask mouth: A Novel Threat to Oral cavity
Authors: P Meenakshi , Mohanan T V Soumya , S Anjali
Published: June 2022

There is a new public health crisis threatening the world with the emergence and spread of 2019 novel coronavirus (2019-nCoV). Covid 19 is transmitted by inhalation or contact with infected droplets. The symptoms are usually fever, cough, sore throat, breathlessness, fatigue, malaise among others. The disease is mild in most people; in some (usually the elderly and those with comorbidities), it may progress to pneumonia, acute respiratory distress syndrome (ARDS) and multi organ dysfunction. Many people are asymptomatic. Masks act as a simple barrier and help stop respiratory droplets from traveling into the air and onto other people. However, wearing a mask for an extended period can create unwanted side effects, such as mask mouth.
A Study on Prevalence and Risk Factors of Anaemia among patients at Tertiary Care Hospital
Authors: R. Sivasakthi , J. Subadradevi , Shanmuga Priya Saranya , Raja Raja
Published: June 2022

Introduction: The prevalence of anaemia is high in developing countries due to poor economic, malnutrition, heredity diseases and pregnancy and reduced health care utilization. Increased Iron requirement and mal absorption of Iron also cause the Anaemia in chronic blood loss during menstrual periods. Methodology: A randomised, cross sectional study was conducted for 6 months Based on inclusion and exclusion criteria.120 anaemic patients were screened for biochemical tests. Results: Out of 120 patients, 32% were male and 68% were female. Majority of patients fall under the age group of 17 to 30 years. The educational status indicates, 40% were high school and 35% were illiterate. Majority of the patients were ideal body weight in 38% and 34% were under over weight. The severity was analysed based on Hb value and found that, 8% patient were severe, 8% were moderate and 88% were in mild anaemia. The mean Hb value was found that 10.82 mg/dl. Only 40% of patients are taking the daily breakfast regularly and 42% of female patients not consuming red meat, fish and chicken. Serum ferritin value is only 5.8 ng/ml, MCV found that 72.30 fL and Hb is 10.82 g/dl. Conclusion: The health education on healthy diet and creating awareness on risk factors of anaemia helps to avaoid the severity and complications of anaemia. The effective Pharmaceutical care services on anaemic patients are essential to prevent the morbidity and mortality rate.
Zika Virus and its Pathogenesis and its Treatment
Authors: Adarsh Gaikwad , Rutuja Patil
Published: June 2022

Zika virus is as similar ass dengue and yellow fever. This virus is from family Flaviviridae.This virus can cause human infection in Asia and Africa. Zika virus is characterized by subclinical or mild influenza like illness. In Guillain –Barre syndrome, there are found 2 to 3 patients of zika virus per 10000. Scientific name of Zika virus is a Flavivirus. (1)
Review on Curcuma aromatic as an Herbal medicine
Authors: P. Shirsat Sangita , P. Tambe Kaveri , D. Patil Gayatri , G. Dhakad Ganesh
Published: June 2022

Curcuma aromatica is also a familiar Chinese herb used for treating diseases with blood stasis and has been consider as an effective anticancer herb. The rhizomes of Curcuma aromatic are used in original medicine for exterior applications on skin diseases, sprain, bruise, in snake poison, holdup the ageing process, pain relief, protecting against liver diseases and also to enhance complexion. The constituents identified in the oil is alpha-pinene, beta-pinene, camphene, 1,8-cineol, isofurano-germacrene, borneol, isoborneol, beta-curcumene, ar-curcumene, xanthorrhizol, germacrone, camphor, and curzerenone and the constituent in oil was found to differ from place to place. Bioactive compounds, counting 1, 8-cineole, ar-curcumene, ar-turmerone, β-elemene, camphor, curcumol, curdione, germacrone, linalool, xanthorrhizol, and zingiberene, from the essential oil of C. aromatica have been verified to possess anticancer properties. Usually used as an anti- inflammatory agent. It possesses a wide range of activities like Anti –inflammatory, anti-tumor, immunological effects, wound healing, anti -fungal, anti -oxidant, anti - microbial, anti-diabetic, anti-platelet and mosquito repellent activity of wild turmeric. The use of analgesic drugs, such as opiates and NSAIDs, for pain relief has been stagnated as these drugs are reported to have adverse side effects, including addiction and gastrointestinal disorders.
Pharmacological activity of Golden heart of The Nature: Piper betel
Authors: C. Shirsath Pratik , P. Shirsath Sangita , R. Jaiswal Neha
Published: June 2022

Piper betel Linn is commonly known as Betel leaf or pan is an important species of the Piperaceae family, is an evergreen and perennial creeper, with glossy heart-shaped leaves that are magnificent reservoirs of phenol compounds with ant proliferative, ant mutagenic, antibacterial and antioxidant properties. Piper betel Linn has been an important medicinal agent in the various traditional and folk systems of medicine in Southeast Asia countries. Piper betel leaves being largely consumed as a masticator and mouth freshener. It is valued as a mild stimulant and also has its use in Ayurvadic medicine. Phytochemicals studies show that Piper betle contains a wide variety of biologically active compounds whose concentration depends on the variety of the plant species. Many research studies on Piper betel has reported that it contains important chemical constituents such as Chavibetol, Chavibetol acetate, Caryophyllene, Allylpyrocatechol Diacetate, Camphene, Chavibetol methyl ether, Eugenol, a-Pinene, f- Pinene, u-Limonene, Saprobe, 1-8-cineol and Allylpyrocatechol mono acetate. These components are valued as a stimulant for its medicinal properties like anti platelet, anti-inflammatory effects as well as immune modulator, gastro protective and antidiabetic activity. This review is focused on emphasizing the varied pharmacological properties of Piper betel Linn. And its future prospects for improved usage in treating numerous conditions. Current study focuses on evaluating antioxidant and antimicrobial potential of betel leaf. Antioxidant and antimicrobial potential study will help to build a database and promote the utilization of betel leaf as a medicinal herb.
Review of Novel Corona Virus Disease (Covid-19) in India
Authors: Sevak Ghanshyam , Singh Chauhan Yashpal , Parihar Narendra , Singh Rathore Mahendra
Published: June 2022

Novel coronavirus also known as severe acute respiratory syndrome Coronavirus 2 (SARS-CoV-2) was emerged from Wuhan, China and have taken catastrophic form globally. India being a dense populated country is also affected by it’s deadly infection. Bats were considered as its primary host but COVID-19 disease became pandemic via human to human transmission by droplet nuclei. The incubation period ranges upto 14 days and main symptoms of disease were noticed as atypical pneumonia, fever, difficult breathing, decreased SPO2 level and ultimately death due to respiratory failure depending upon immune status of the patients. Coronaviruses are positive-sense, single-stranded RNA viruses and harbour a genome (30 kb) consisting of two terminal untranslated regions and twelve putative functional open reading frames (ORFs), encoding for non-structural and structural proteins. There are sixteen putative non-structural proteins, including proteases, RNA-dependent RNA polymerase, helicase, other proteins involved in the transcription and replication of SARS-CoV-2, and four structural proteins, including spike protein (S), envelope (E), membrane (M), and nucleocapsid (N). SARS-CoV-2 infection, with a heavy viral load in the body, destroys the human lungs through cytokine storm, especially in elderly persons and people with immunosuppressed disorders. A number of drugs have been repurposed and employed, but still, no specific antiviral medicine has been approved by the FDA to treat this disease. This review provides a current status of the COVID-19, epidemiology, an overview of phylogeny, mode of action, diagnosis, and possible treatment methods and vaccines.
Journey of Chloroquine/ Hydroxychloroquine in the management of COVID-19
Authors: Sekhri Kavita , Bhanwra Sangeeta , Nandha Ruchika , Aditya Suruchi , Bhasin Deepak
Published: June 2022

Chloroquine was discovered in 1934 and since then it is used as an antimalarial drug saving millions of lives. Chloroquine and its analogue Hydroxychloroquine possess pleotropic pharmacological actions and are of proven value in multiple conditions ranging from protozoal to autoimmune diseases. Advantage with these drugs is their well-documented tolerability profile. In Severe Acute Respiratory Syndrome Corona virus-2 (SARS-CoV-2), these drugs in vitro showed promising results working at multiple sites ranging from prevention of entry of the virus into human cells, halting the multiplication by altering the pH of internal organelles towards basic side and via exocytosis. These drugs also act as immunomodulators to prevent flare up of cytokines and interleukin cascade, thus preventing multiple organ dysfunction syndrome. In this review we trend the journey of these drugs, how high hopes were pinned to their use but they failed to show any mortality benefit in hospitalized patients. However, still certain studies are underway to explore their role in prophylaxis or otherwise. Medline, Medscape, EMBASE, Cochrane database, Scopus and clinicaltrials.gov were searched using terms like “SARS-CoV-2”, “COVID-19”, “Chloroquine” and “Hydroxychloroquine”.
Recent Advances in Tivozanib plus Nivolumab Combinatorial Strategies in Renal Cell Carcinoma
Authors:   Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA, Motzer Robert , Choueiri Toni ,   Lank Center for Genitourinary Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA, Albiges Laurence ,   Medical Oncology, Gustave Roussy, Villejuif, France., Figlin Robert ,   Cedars-Sinai Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Health System, Los Angeles, CA
Published: June 2022

The treatment landscape of advanced renal cell carcinoma (aRCC) has witnessed significant benefits from the introduction of VEGF TKI/ICI (vascular endothelial growth factor receptor tyrosine kinase inhibitor/immune checkpoint inhibitor) combination in the first-line treatment. Such outcome benefits could extend to the relapsed/refractory setting with an effective, well-tolerated novel combination. Since the U.S. FDA approval of tivozanib monotherapy for the treatment of adult patients with relapsed or refractory advanced RCC following two or more prior systemic therapies,1 there is growing interest in exploring its full potential in combination with anti-PD-1 like ICI agents. In this roundtable discussion, internationally renowned cancer experts brainstorm the potential immunomodulatory capabilities of tivozanib plus nivolumab combination as first-liane and beyond settings in patients with metastatic RCC. The expert panel also explore potential data from previous and ongoing clinical trials and shared their perspectives about a tolerable safety profile and promising antitumor efficacy
Debt to GDP Ratio and inflation from the perspective of Functional Finance Theory and MMT
Authors: Tanaka Yasuhito
Published: June 2022

This paper will examine the relationship between budget deficit, inflation rate and debt to GDP ratio from the perspective of Functional Finance Theory and MMT (Modern Monetary Theory). Using a basic macroeconomic model in which the interest rate of government bonds is endogenously determined, with overlapping generations model in mind, mainly, we show the following results.1. If the proportion of the savings consumed is smaller than one, the larger the budget deficit is, the larger the inflation rate is.2. If the proportion of the savings consumed is smaller than one, the larger the inflation rate is, the smaller the debt to GDP ratio is. Therefore, excessive budget deficits cause inflation, which results in a smaller debt to GDP ratio. A large budget deficit is not associated with a high debt to GDP ratio.3. The larger the budget deficit is, the weaker the condition on the proportion of savings that is consumed in order for the debt to GDP ratio not to diverge is.
منهجية النصيحة في المنظور الاسلامي
Authors: GHALIB ALI MUGHALISS AHMED
Published: June 2022

نظرا للأهمية التي تكتسبها النصيحة في المنظور الاسلامي فقد رأيت أنه من الواجب التعاطي مع هذا النوع من الدراسات والبحوث التي تلامس الحياة اليومية للانسان المسلم والمفاهيم والقضايا التي تؤثر هي الاخرى سلبا او ايجابا في واقعه المعيش، وقد قسمت هذا البحث الى مقدمة ومدخل وثلاثة مباحث وخاتمة.

اما المقدمة: فقد اوجزت فيها الدوافع والدواعي والاسباب التي كانت وراء هذا البحث والمنهج المناسب للبحث.

واما المدخل: فقد جعلته للتعريفات المتعلقة بالبحث ككشاف معرفي له.

اما المبحث الاول :فقد جعلته للأسس المنهجية التي تقوم عليها النصيحة في المنظور والتصور الاسلامي معتمدا على ذلك بما جاء في كتاب الله وسنة المصطفى صلى الله عليه وسلم.

واما المبحث الثاني: فقد احتوى على المقاصد والاهداف الدينية والاجتماعية والتربوية التي تقف خلف النصيحة في المنظور الاسلامي.

اما المبحث الثالث: فقد كان للوسائل التي تتوفر في المجتمع ويجب على الناصحين والموجهين والخطباء والتربويين والدعاة استخدامها للتواصل مع المستهدفين.

اما الخاتمة: فقد كانت الخلاصة لما توصل اليه البحث وما يجب علينا في المجتمع الاسلامي حيال منابر النصيحة ووسائلها واجهزتها المختلفة حتى تجد النصيحة الطيبة والمخلصة طريقها الى وعي وسلوك ابناء المجتمع على اختلاف اعمارهم ومستوياتهم.
National resilience of Ukraine: hybrid threats challenge response and prevention strategy: national report
Authors:   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Pyrozhkov Sergiy , Khamitov Nazip , Lyubiviy Yaroslav , Zhulay Valeriy , Yas' Oleksii , Verstiuk Vladyslav , Yakubova Larysa , Lysenko Oleksandr , Udod Oleksandr , Golovakha Yevgen , Petrushyna Tetiana , Reznik Oleksandr , Stegniy Oleksandr , Dembitsky Sergiy , Kresin Oleksiy , Skrypniuk Oleksandr , Yavir Vera , Tarasyuk Volodymyr , Kresina Iryna , Shemshuchenko Yurii , Savchuk Kostyantin , Kyiak Maksym , Shmorgun Olexandr , Kiyanitsa Leonid , Samchuk Zoreslav , Zelenko Galyna ,   The National Academy of Sciences of Ukraine
Published: June 2022

The national report, prepared by the staff of the Section of Social Sciences and Humanities of the National Academy of Sciences of Ukraine. The report seeks to justify the concept of national resilience as resilience of the civilizational subject of a country in modern geopolitical conditions. The report also aims to define country’s strategy for ensuring the balance of development on the one hand and successful counteraction to external and internal threats, including hybrid ones on the other. The question of interaction of national resilience and national security of a state is investigated, the problem of institutional maintenance of strategy of national resilience is set.
Uterine atony: Current trends in invasive treatment
Authors: Efthymia Thanasa  , Evangelos- Ektoras Gerokostas  , Gerasimos Kontogiorgis  , Evangelos Kamaretsos  , Ioannis Thanasas
Published: June 2022

Uterine atony is the leading cause of postpartum hemorrhage. The etiological mechanism has not been fully clarified. Various predisposing risk factors either pre-existing in pregnancy or appearing during pregnancy have been blamed to date for causing postpartum hemorrhage and uterine atony. The diagnosis of uterine atony is clinical. The diagnosis presupposes the confirmed emptying of the endometrial cavity and the exclusion of traumatic etiology bleeding from the genital system. The multidisciplinary treatment after the early recognition of bleeding it is useful to focus on achieving satisfactory uterine contraction with administration matrix contraceptives (oxytocin, erysipelas alkaloids, prostaglandin, carbetocin) and in maintaining its hemodynamic stability with the use of preservatives (massages, double compression of the uterus) and surgical techniques . The tamponade balloon Bakri, the package from gauzes, several types of hemostatic sutures, ligation of internal iliac arteries, uterine arteries embolism and obstetric hysterectomy are older and newer techniques included in the modern invasive treatment of uterine atony .In this article based on recent bibliography is attempted a review of this obstetric complication, regarding its basic principles of invasive treatment, the timely and correct application of which can yield the best possible result and ensure the best health of mother.
Microbiological evaluation of the environmental quality of a pharmaceutical plant in Lagos, Southwest Nigeria
Authors: Ojo-Omoniyi OA  , Akinnola OO  , Adeduro MR  , Mmadu CP
Published: June 2022

The evaluation of predominant microorganisms distributed in the air of the critical rooms in the production plant of a pharmaceutical company in Agege Local Government area, Lagos-Nigeria was investigated using settle- plate method. A total of seven critical rooms in the production facility that is, Dispensary, Granulation, Blending, Blistering, Tableting, Syrup, and Syrup filling rooms were sampled respectively under aseptic conditions. These samples were processed in duplicates on Sabouraud Dextrose Agar (SDA) and Tryptone Soya Agar (TSA) and incubated at 25ºC and 37 ºC respectively. Thereafter, microorganisms were isolated and identified using standard and conventional methods. The data obtained were analyzed to find the microbial distributions in the environment of the pharmaceutical facility. Eight bacterial species were isolated from different locations in the pharmaceutical facility, they were of the following genera; Staphylococcus (12.5%), Micrococcus (50%) and Bacillus (37.5%). Most of the microorganisms found in this study belong to the genus Micrococcus (four species) and three Bacillus species and one Staphylococcus species. Despite the compliance of this company with international standards, the above mentioned microbial species were still found within the facility. Hence, compliance with the international specified standard alone, that is, Good Manufacturing Practice (GMP) does not guarantee sterile pharmaceutical product from the industry. Therefore, other microbial quality assurance procedures must be strictly adhered to in order to have products that comply with international specifications. The microbial isolates from the pharmaceutical facility include: Bacillus subtilis, Bacillus badius, Staphyloccocus aureus, Proteus mirabilis, Microccocus sp. Pseudomonas aeruginosa, Enterobacter aerogenes, Citrobacter sp. Talaromyces sp. Aspergillus tamari.
Analisis Kontribusi Keuntungan Atas Produk- Produk Pada CV. Salim Tailor Di Tenggarong (Penerapan Linear Programming Metode Simplek)
Authors: Sari Lisa Novita , Palinggi Yonathan , Adawiyah Raudatul
Published: June 2022

The main objective of this study was to find out whether the production amount of CV. Salim Tailor In Tenggarong has been at the optimum point to generate maximum profit contribution and to know which type of products that generate maximum profit contribution from various products produced by CV Salim Tailor in Tenggarong.The research result is indicated that business well get maximal profit from product Pants (X1) with respective optimal production quantities are rounded to 24,4253 unit itâ€™s mean that 24 unit plus 1 unit product on process productions 42,53% and also product PDL (X5) with respective optimal production quantities are rounded to 13,472% unit itâ€™s mean that 13 unit plus 1 unit product on process productions 4,72%Â  with the maximum profit Rp. 29.188.950 for 1 month.For the time of measurement and cutting or process 1 (S1) still leave time during 5,0833 minute, this is indicated that the company have a lost time on the process 1 for more or less 0,08 hours for 1 month. Keywords: Profit Contributions (Application of Linear Programming Simplex Method)
Pengaruh Citra Toko Dan Kepercayaan Toko Terhadap Loyalitas Konsumen Pada Toko Station Game Di Tenggarong
Authors: Ramadhani Rahmat , Iskandar Iskandar , Luthman Awang Yacoub
Published: June 2022

Abstract :Toko Station Game Tenggarong which is a branch of Station Celular Samarinda which serves the sale and purchase of mobile phones and accessories that are located on the lake Semayang RT.12 Kelurahan Melayu Tenggarong District. The goods are sold at Tenggarong Station Station Shop directly imported from jakarta and surabaya. The purpose of this study is to find out whether the variables of Store Image and Store Trust affect simultaneously to Consumer Loyalty At Station Station Game In Tenggarong, to find out, Are the variables of Store Image and Store Trust partially influence on Consumer Loyalty At Station Station Game Di Tenggarong and to know, Among the independent variables are the variables which have the most dominant influence on the Consumer Loyalty At Station Stores Game In Tenggarong? From both result of partial correlation test above seen value of Scitra variable of store bigger influence than store trust variable, so store image variable is the most dominant variable influence to consumer loyalty. From the description, it can be concluded that the second hypothesis in this study "That, Variable Image of Stores Which Has The Dominant Influence On Consumer Loyalty At Station Game Stores In Tenggarong" in accepted and proven truth. Â Keywords: Consumer Loyalty, Store Image And Store Trust
Pengaruh Punishment Dan Reward Terhadap Disiplin Kerja Pada PT. Tri Mandiri Selaras Di Tenggarong
Authors: Wahyuni Syanti , Sabran Sabran , Hermanto Muhammad
Published: June 2022

Abstract :Â Â Â Â Â Â Â Â Â Â  PT Tri Mandiri Selaras is a showroom company of Daihatsu cars equipped with authorized workshops for routine checks and maintenance as well as vehicle engine repair customers who are located on Aji Lake RT.05 Malay Village Kutai Kartanegara Regency. The number of employees working on PT Tri Mandiri Selaras are 26 people divided into 7 people mechanics, 6 administrators, 4 sales people, 2 office boys, 2 cashiers, 1 person, 1 head marketing and 3 human resouch developmen. The study was conducted in April 2018, the population data available in April 2018 was 25 people and the number of samples used in this study were 25 people. The analysis tools used are multiple regression analysis and hypothesis testing using F test and t test with the help of SPSS For Window 20.0. The results of F test calculations (simultaneous correlation / joint), variable punisment (X1) and reward (X2) simultaneously affect employee work discipline. Then the independent variables have a significant relationship or employee discipline variables influenced by the variable punisment (X1) and reward (X2). From both result of partial correlation test above seen the biggest punisment variable value compared to reward variable, so the punisment variable is the most dominant variable affecting employee work discipline. Â Keywords: Punishment, Reward, Work Discipline
Pengaruh Bauran Pemasaran, Pelayanan Terhadap Keputusan Pembelian Telepon Seluler (Studi Kasus Toko Bina Mitra Usaha Desa Cipari Makmur)
Authors: Muniroh Muniroh , Sabtohadi Joko , Abdullah Rahim
Published: June 2022

Abstract:The purpose of this research is to know variable influence the product , the price of , and services of the decision of the purchase , either simultaneously or partial .The study is done in the form of survey , by adopting both explanation reseach .Variable products , have a negative influence insignificant of the decision of the purchase .While variable prices and service significant have had a positive impact of the decision of the purchase .Then the product , the price of , and services jointly significant on variables customer satisfaction .Â Keywords; The Product, The Price, Service, Decision The Purchase
Implementasi Peraturan Bupati Nomor 33 Tahun 2016 Tentan Pemberian Tambahan Penghasilan Aparatur Sipil Negara Terhadap Peningkatan Disiplin Dan Kinerja Pegawai Pada Kantor Kelurahan Maluhu Kecamatan Tenggarong
Authors: Safutra Dendi Dwi , Syahruddin S Syahruddin , Hermanto Muhammad
Published: June 2022

Abstract:The purpose of this study was to determine the magnitude of the effect of giving additional employee income (TPP) to increase the level of discipline and employee performance at the Maluhu Sub-District Office in Tenggarong District.The problem is that there are quite a lot of employees who are diligent in being absent in the morning but one hour after that the employee can go straight out of the office and come back one hour later before being absent home in the afternoon. As for discipline in terms of the effectiveness of the use of work time which should not have experienced a significant increase or change. Employees of the Maluhu Urban Village Office are absent only to pursue or fulfill incentive payment requirements.This research was conducted using quantitative methods. The sample used was 24 people. The analysis tool uses 2 linear dependent paradigm regression, with hypothesis testing using the t test and correlation.The results of TPP t count with work discipline is 6.485 while t table with degrees of freedom at the level of 5% (a = 0.05), amounting to 1.717 which means (t count 6.485> t table 1.717). Thus H0 is rejected and H1 is accepted. Thus the first hypothesis proposed in this study was accepted because it proved the truth.The results of TPP t count with employee performance is 4.012 while t table with degrees of freedom at the level of 5% (a = 0.05), amounting to 1.717 which means (t count 4.012> t table 1.717). Thus H0 is rejected and H1 is accepted. Thus the second hypothesis proposed in this study was accepted because it proved the truth.From the results of the comparison of the second partial correlation of the Y variable above, it can be seen that the correlation value between the variables of TPP money and work discipline is more than the value of TPP money with a performance of 0.810 versus 0.650. So that it can be concluded that giving TPP money so far to employees of the Maluhu Village Office in Tenggarong is far more able to have a dominant influence on work discipline than on performance improvement. So that the third hypothesis in this study is accepted.Â Keywords: Additional Employee Income (TPP), Discipline And Employee Performance