bluuebunny/crossref_metadata_2025 huggingface dataset:
Ocular Surface plasmacytoma
Authors: Bernaus Marta , Cid-Bertomeu Pau , Vilardell Felip , Huerva Valentin
Published: July 2022

Conjunctival plasmacytomas are rare tumours that may be solitary or related with multiple myeloma (MM), a malignant systemic plasma cell neoplasm that tends to metastasize. Plasma cell infiltration of bone marrow and presence of immunoglobulin is characteristic of MM. It may cause extraskeletal spread being the ocular tissue involvement very rare. We report a case of a 57-year-old male patient affected of a caruncular mass that has increased of volume in the past two months. The patient was previously diagnosed of extramedullar affection of MM and he had no treatment in that moment. An excisional biopsy confirmed the diagnostic of a conjunctival plasmacytoma secondary to MM Immunoglobulin D (IgD). Second line systemic chemotherapy treatment produced total regression. Ocular surface plasmacytoma is an uncommon entity that has to be suspected in a known myeloma patient with a conjunctival mass growth, including the caruncle. The presence of conjunctival plasmacytoma may be a sign of recurrence and insufficient chemotherapy as showed our case. Therefore, regular ophthalmological examinations should be done to the myeloma patients without any treatment.
The Metabolic Model of Heart Failure; the Role of Sodium-Glucose Co-transporter 2(SGLT2) Inhibition
Authors: Shaban Mohammed , Sosa Franklin , Rodriguez-Guerra Miguel , Vittorio Timothy
Published: July 2022

The sodium-glucose co-transporter-2-inhibitors (SGLT2I) recently gained a unique role in managing the heart failure reduced ejection fraction. These inhibitors reduce cardiovascular (CV) risk factors, including plasma glucose, blood pressure, albuminuria, body weight, and renal events in the long term. The clinical trials proved their role in reducing hospitalization for HF, CV and all-cause mortality, atherosclerosis-related events, and CKD progression. Initiating this medication on decompensated heart failure or post-discharge reduces the risk of re-hospitalization. These co-transporter inhibitors reduced heart failure and kidney events regardless of baseline biomarker concentration or diabetes mellitus status. This article aims to the metabolic paradigm and cellular metabolism by exposing the available clinical trials of this novel therapy for heart failure, uncovering the possible mechanisms of action on the CV system, and describing the positive effect on prognostic markers as pro-BNP, as well as changing the plasma renin-aldosterone activity, cardiac troponin T (hs-cTnT), and insulin-like growth factor-binding protein 7 (IGFBP7).
Management of Spasticity Caused by Thrombotic Brain Injury with Incobotulinumtoxina in a Young Patient: A New Paradigm
Authors: Belen Paba , Irene De
Published: July 2022

Case: Acquired brain damage is one of the most complex pathologies that affect the central nervous system, there is great variability in its pathophysiology, from traumatic focal injuries to diffuse axonal injuries, including spasticity. It supposes a great comorbidity and functional repercussion in patients, hindering their subsequent recovery. We report a case of a young patient with a history of quadriplegia due to acquired brain damage secondary to thrombosis of the dural sinus. The patient presented sensorimotor deficit, restricted function, and a great situation of dependency. He required three cycles of high doses of incobotulinumtoxinA (IncoBoNT) according to his specific need, the first infiltration was 800 U, the second 800 U, and the last 500 U over a period of 14 weeks. Thanks to the previous objectives agreement with the patient the results were satisfactory and relevant for him, presenting a great functional improvement of spasticity and associated pain, as assessed by the visual analog scale score.Conclusion: IncoBoNT at high doses and short intervals has been shown to be an effective and valuable tool for personalized treatment adapted to the needs of severely affected neurological patients.
An Overview of Nanoparticles for Treatment of Retinoblastoma: Disease Characteristics and Experimental Approaches
Authors: Patel Minesh , Conte Eric , Luo Nan , Patel Virali , Martinez Ashley , Kim Hae , Goli Naga , Campbell Robert
Published: July 2022

Retinoblastoma is the most common type of eye cancer in infants and children. Probability of saving vision and survival depends upon two main factors: progression of the disease from unilateral to bilateral and severity of the disease. In order to effectively treat retinoblastoma and retain vision, it is crucial to focus treatment options on reducing toxicity and nonspecific targeting while enhancing drug delivery, cellular uptake, and accumulation of chemotherapeutic agents to their specific target sites. Rapid elimination from blood circulation is the greatest obstacle that conventional chemotherapeutic agents face on journey to their target sites. Target specific nanoparticles have proven to be a useful tool in efforts to overcome challenges typically encountered by targeting strategies. Development of nanoparticles loaded with chemotherapeutic agents can allow for more selective tumor targeting, extended drug circulation times, and reduced drug-associated toxicity. Nanoparticles can significantly improve the treatment efficacy in retinoblastoma. The purpose of this review is to discuss the important characteristics and differences of nano delivery systems used against cellular and in vivo models of retinoblastoma, particularly as they relate to the popular Y79 retinoblastoma cell line.
The Impact of The Immune Check Point on Cost in Lung Cancer: Duration of use
Authors: Guirgis Helmy
Published: July 2022

Background: Monotherapy and combinations of Pembrolizumab (Pembro), Atezolizumab (Atezo) and Cemiplimab (Cemi), prolonged overall survival (OS) in advanced/metastatic non-small cell lung cancer (a/m NSCLC). Pembro demonstrated 5-year OS gain. The duration of therapy of the immune check point inhibitors (ICI) has not been defined. One-year adjuvant Durvalumab (Durv) and Atezo significantly extended OS. Neoadjuvant few cycles resulted in positive outcomes. ICI costs are relatively expensive and multiply with further use with no containment on sight. The 2019 CAR-T cost was limited to $450,000. There are unmet needs for coherent drug cost policies. We aimed 1- Explore the factors which impact ICI costs in lung cancer 2- Navigate cost-saving strategy based on generics, therapy duration 3- Explore the possibility whether adjuvant and neoadjuvant treatment impact costs Methods: Annual drug prices were quoted and calculated. Utilization thresholds were set for ICI monotherapy at $450,000 and combinations at $550,000. Results: Estimated annual Pemetrexed (Peme) costs were $113,793, generic chemicals < $1,000 and Bevacizumab (Bev) $150,126. The mean of 6 ICI was $148,000. Pembro 2-year costs were $334,652, below the the proposed $450,000 thresolds. The 3-year costs of $501,978 and the 5-year $836,630 were above $450,000. Atezo + Bev+ Peme combination had the highest 2-year $722,977 costs, above $550,000. There was no significant difference in cost between Atezo + Peme $422,725, Pembro + Peme $448,445 and Cemi + Peme $425,385. These combinations were below the $550,000 threshold. Costs decreased using generics by 25%. Extending ICI use by 6-12 months increased combination costs by 25-50%. Adjuvant 1-year Durv costs were $148,013 and Atezo $154,446, half the 2-year. Using response rates, cost of 2-4 cycles of neoadjuvant Nivolumab (Nivo) were only $25,000 - $50,000. Conclusion: Generics, limited ICI duration, utilization thresholds and neoadjuvant therapy significantly reduced drug costs. Neoadjuvant therapy had the highest impact on cost reduction.
The Role of the Exalted Mind in the Observer Observed Quantum Reality
Authors: Yang Keun , Kafatos Menas
Published: July 2022

The great advances in science precipitated by the advent of quantum mechanics in the 20th century have profound implications for the nature of reality. The universe is now assumed to be fundamentally quantum at all scales of existence. As such, ancient questions about what the roles of human beings in the universe are, what is the relationship between the observer and the observed, the role of the mind, existence itself and the nature of experiences, can now also be approached in new scientific ways. This provides the opportunity to explore mathematical formalisms that relate to relationships between the observer and the observed, through three principles or universal laws which apply at all levels of existence. These principles form the essence of a vast ocean of qualia of experience. Such approaches that we advocate here provide a formalism that goes beyond specific interpretations of quantum mechanics and have strong philosophical foundations in both Western philosophy as well as the monistic contemplative systems of the East. We present a plausible thesis that what is the unifying principle of all existence is universal Consciousness, which when turned within is pure Awareness of Being. The mind and the countless experiences of qualia in this inner vision encompass ancient eternal views of contemplation where the observer, the observer and the process of unifying them form an undivided wholeness. The exalted ancient yet modern view would resonate with both the non-dual ancient teachings as well as different interpretations of quantum mechanics wherein the observed system and the observing subject are inexorably tied together in an undivided Wholeness of Being. The role of the mind is critical and we use the term Exalted Mind to distinguish higher functions from ordinary mind. The implications for humanity are indeed profound, in our view form the foundation of the emerging scientific and medical paradigms, the dawn of a new era of conscious non-dual, science-based Awareness.
Interrelations between Apoptosis and Autophagy in Autoimmune and Malignant Diseases
Authors: Udristioiu Aurelian , Martin Adina , Giubelan Alexandru , Daniela Papurica , Daniela Maria , Martin Liviu , Nica- Badea Delia
Published: July 2022

The lifespan of a cell in the body oscillates between two fundamental processes, Autophagy, which ensures cell survival, even under conditions of cellular stress, and Apoptosis, which programs the end of cell life, not before the renewal of a new cell in a tissue. Overall, there is a continuation of daily life until a specified date of highlighting the length of the telomeres, in the chromosomal analysis of the cell. Apoptosis, in the scheduling of cell life, is a normal process which is different from cell necrosis that occurs as a result of physical or chemical aggression. The decision to activate a suicide process is made based on intrinsic or extrinsic apoptotic messages. The intrinsic inducers of apotheosis come from the mitochondria or nucleus. Extrinsic inducers of apotheosis are ligands, cytokines for death receptors, (DR-Death receptors) on each cell surface. Autophagy: is a homeostatic and catabolic processes that allows the sequestration and lysosomal degradation of cytoplasmic organs and proteins, important for maintaining genomic stability and cell survival. Autophagy is regulated by the Beclin 1 protein, which forms a complex with a class III enzyme, phospho-inoside 3-kinase (PI3K), and serves as a platform for the recruitment of other proteins critical for autophagosome formation. Conclusions: The most important regulatory mechanism in autoimmunity and oncogenesis process are death receptors, caspases, mitochondria, the Bcl-2 family proto-oncogenes and tumor suppressor gene P53. Pharmacological manipulation of autophagy for cancer prevention and treatment will depend on our ability to successfully recognize the functional status of autophagy in tumors, and the availability of specific autophagic modulators.
The Effects of Curcuma Longa on the Osteoarthritis: A Systematic Review of Placebo-Controlled Clinical Studies
Authors: Alvarenga Luiz , Marconato Gabrielle , Fracaro Gabriele , Laurindo Lucas , Araujo Adriano , Rubira Claudio , Dias Jefferson , Barbalho sandra , Guiguer Elen
Published: July 2022

Osteoarthritis (OA) is a joint disorder characterized by chronic, degenerative, and irreversible inflammation leading to pain and disability. The standard drugs are ineffective for many patients and are usually associated with numerous side effects such as gastrointestinal complaints. Curcuma longa and its bioactive compounds have been considered for OA. The objective of this study was to perform a systematic review of the effects of Curcuma longa and its derivatives on OA. Pubmed, Cochrane, and Embase were searched, and PRISMA guidelines were followed to build this review. Only Randomized Clinical Trials (RCTs) that performed placebo-comparison were included. Most included studies showed that Curcuma longa or formulations prepared with curcuminoids can benefit the OA scores such as Visual Analog Scale, Knee injury and Osteoarthritis Outcome Score, Western Ontario and McMaster Universities Osteoarthritis Index; and Lequesne's pain functional index. The use of Curcuma longa extracts or curcuminoids can benefit patients with OA. Nevertheless, the available RCTs show treatment time, doses, and formulations heterogeneity. Thus, the standardization of RCTs can guide researchers and physicians on the dosages and formulations that are most effective in addressing this condition, which is very prevalent in the world's populations.
Price Volatility of Ornamental Plants in Batu Municipality
Authors: Khofifah Hamidatul , Nugroho Tri Wahyu , Sujarwo Sujarwo
Published: July 2022

The imbalance between supply and demand of ornamental plants in the market cause fluctuations that lead to price volatility. This study aimed to analyze the price volatility of ornamental plants with high economic value, such as orchids, adenium, aglaonema, anthurium, and palm. This study also analyzed the long-term and short-term relationship between the production and prices of these ornamental plants. The data used were the productions and prices of orchid, adenium, aglaonema, anthurium, and palm at the producer level from 2012 to 2020 obtained from the Agriculture Office of Batu Municipality. Volatility analysis was carried out using the ARCH/GARCH method, the long-term relationship was analyzed using the Johansen cointegration test, and the short-term relationship was carried out using the Error Correction model. The results of volatility analysis showed that all the ornamental plants studied had low price volatility. In addition, the productions and prices of the ornamental plants were cointegrated in the long run, but only the orchid had a short-term relationship with an adjustment period of 2.6 months.
Sources of mesenchymal stem cells and its potential
Authors: Singh Abhishek , Khanna Manish , Gulati Arun , Sinha Gautam , Verma Satyajeet
Published: July 2022

Mesenchymal stem cells, because of their ability to differentiate along variable cell lineages and renew themselves is a topic of interest in orthopedics for their potential role in avascular necrosis of femoral head, osteoarthritis, intervertebral disc disease, ligamentous and meniscal injuries, inducing growth in osteogenesis imperfecta and gene therapy. They also possess immunosuppressive and immunomodulatory properties. Mesenchymal stem cells can be procured from different tissue sources, such as umbilical cord, synovial tissue, breast milk, menstrual blood, adipose tissue, bone marrow, dentine pulp etc. In this review, we have attempted to make a study of the recent advances in emerging new sources of mesenchymal stem cells and their therapeutic potentials.
Bilateral osteochondroses of the accessory ossification centre of the medial malleolus: A rare entity
Authors: Ahmad Javed , Patel Brijmohan , Srivastava Vivek Kumar , Khanna Manish
Published: July 2022

We are reporting a rare case of a painful accessory ossification center of the bilateral medial malleoli in a 9 years old girl. Patient was not involved in any sport activity. There was no local foot deformity and limb malalignment. The patient was treated conservatively. There was complete clinical and radiographic healing of the medial malleolus eight months after the first presentation. Osteochondrosis of the accessory ossification center of medial malleolus is generally unilateral and bilateral involvement is very rare. There are various differential diagnosis for this pathological condition with similar clinical features and presentation in this age group. We ruled out the uncommon pathological conditions causing chronic pain in the medial malleolus during this period of skeletal growth. We consider this painful condition to be classified as a bilateral osteochondroses of the accessory ossification center of the medial malleolus. Osteochondrosis of the accessory ossification center of the bilateral medial malleolus is a rare entity. Due to rarity of disease and common presentation similar to other disease this is commonly misdiagnosed or missed in clinical practice. Osteochondrosis is characterized by a disturbance of endochondral ossification in skeletally immature patients and should be investigated in children having a history of persistent foot and ankle pain. An increased clinical attention to this painful condition could lead to improved diagnosis and treatment among the paediatric age group.
13 Biennial International Congress of Orthopaedic Rheumatology (ICOR-IORACON – 2022, Kolkata; 17 – 19 June, 2022); Academic report update
Authors: Keshkar Sanjay , Khanna Manish
Published: July 2022

13 Biennial International Congress of Orthopaedic Rheumatology (ICOR), wasorganized for the first time in ‘City of Joy’ by Indian Orthopaedic Rheumatology Association (IORA) under the aegis of WBOA in association with ESI-PGIMSR, ESIC Medical College, Joka Kolkata from 17 – 19 June 2022.

The main Conference was organized from 18 – 19 June 2022 in Bishwa Bangla Convention Centre (The biggest convention Centre of India). Apart from the main conference, there were 8 Preconference workshops, conducted in two Premier Medical Institutions of Kolkata on different topics on 17 June 2022. Hallmark of entire Conference was lively interactive discussions amongst delegates. Academic Report Update of Pre-conference workshops & Main conference are highlighted in this Short Communication.
Inventário florístico em praças públicas do município do Cabo de Santo Agostinho, Pernambuco, como indicador de planejamento ambiental
Authors: Aniceto Fabricio David Simplicio , Gadelha Fernando Henrique De Lima , Paz Diogo Henrique Fernandes da
Published: July 2022

O objetivo deste estudo foi analisar a arborização das praças do bairro Cohab, Cabo de Santo Agostinho, estado de Pernambuco. O inventário total das áreas consistiu na coleta de parâmetros quantitativos: altura total (Ht) e primeira bifurcação (Hb); e qualitativos: fitossanidade, sistema radicular, avanço da copa, podas necessárias e realizadas e afastamento de construções. A classificação da origem das espécies e o cálculo dos índices de Shannon-Wiener (H’) e Pielou (J) foram realizados. O levantamento resultou no inventário de 155 indivíduos pertencentes a 37 espécies, em que predominaram espécies exóticas ao território brasileiro, totalizando 14 famílias botânicas. Ficus benjamina foi a espécie mais dominante, enquanto Arecaceae foi a família com maior número de espécies. A maioria dos indivíduos foi classificada como pequeno porte e prevaleceram espécimes com Hb abaixo do recomendado na literatura. Foi observado que os indivíduos não apresentam excessivos problemas com afloramento de raízes ou fitossanidade, porém, foi encontrado um considerável percentual de espécimes em conflito com estruturas urbanas e com podas mal executadas. Os índices calculados foram H’ = 3,02 e J = 0,83, indicando que as praças públicas avaliadas possuem uma diversidade mediana de espécies. Assim, em função dos dados obtidos nesta pesquisa, é notável que o planejamento e manejo da arborização urbana são feitos de maneira inadequada.
A Educação Matemática e a formação de professores: o que desvela a produção acadêmica dos licenciados do IFPB Campus Cajazeiras
Authors: Assis Marcos Antonio Petrucci de , Sousa Manaires Do Carmo Lopes de , Santos Rodiney Marcelo Braga dos , Correia Dlaânio Da Silva
Published: July 2022

O presente artigo trata de uma pesquisa de cunho qualitativo, como um estudo de caso em torno dos discentes da Licenciatura em Matemática ofertada pelo IFPB Campus Cajazeiras. A referida pesquisa teve por objetivo identificar, nos trabalhos acadêmicos – mais especificamente nos Trabalhos de Conclusão de Curso (TCCs) defendidos no período de 2014 a 2018 – a inquietação com a formação do professor de Matemática, com foco na Educação Matemática Crítica e no ensino de Matemática como instrumento para leitura e escrita do mundo e para a promoção da equidade, justiça e construção da cidadania. Após coletar os trabalhos, uma análise de conteúdo com base nas palavras-chave e nos textos dos resumos foi realizada, a partir da qual se observou que esta pesquisa impacta em três possibilidades: 1ª) de trazer à tona a discussão em torno do ensino de Matemática como instrumento de leitura e escrita de mundo no âmbito da formação inicial de professores no seio da instituição pesquisada; 2ª) de aproximar os licenciandos participantes de nossa pesquisa a essa temática, por meio das leituras e escritas que fomentaram as discussões no grupo de estudos; e 3ª) de montar um perfil da produção acadêmica, em nível de TCC, dos egressos. A conclusão é que essas contribuições podem se unir a olhares mais diversos e amplos, para reverberar nas práticas de sala de aula, tanto dos docentes como dos discentes, iniciando nas salas da licenciatura e chegando às salas de aula de Matemática da escola básica.
Influência de retrofits sustentáveis nos custos de ciclo de vida de edificações de alto padrão
Authors: Conceição Gabriel Pereira da , Gama João Luiz Calmon Nogueira da , Costa Dayana Bastos
Published: July 2022

O Custo do Ciclo de Vida (CCV) é uma técnica de avaliação de custos associados a um produto, que visa minimizá-los e pode ser usada para selecionar projetos alternativos de construções. O presente trabalho justifica-se pela carência de estudos, no Brasil, sobre os custos das diferentes fases de um empreendimento. Assim, o objetivo desta pesquisa é analisar a influência da realização de retrofits sustentáveis nos custos totais de ciclo de vida de edificações residenciais de alto padrão. A análise de CCV foi desenvolvida pelo método do valor presente e envolveu o estudo de duas edificações residenciais. Como resultados, notou-se que os custos associados à operação e manutenção equivalem a mais de 60% dos custos totais das edificações. Percebeu-se que, por meio da redução do consumo de energia operacional, pode-se reduzir o custo total do ciclo de vida desses edifícios. Em relação à viabilidade da implementação das propostas de retrofit, concluiu-se, diante dos resultados, que a implementação de medidas de retrofit em qualquer momento do ciclo de vida de um edifício gerará benefícios ambientais, porém, para que ocorram benefícios econômicos, é preciso que essas medidas sejam adotadas o quanto antes, sendo o ideal serem planejadas desde a fase de concepção de projetos.
Análise numérica termoestrutural de vigas de madeira em situação de incêndio
Authors: Fernandes Felipi Pablo Damasceno , Munaiar Neto Jorge
Published: July 2022

O estudo de elementos estruturais de madeira em situação de incêndio pode ser feito por meio de análises experimentais, teóricas e numéricas, sendo a última uma solução mais econômica e em que é possível considerar não linearidades do material. Nas modelagens numéricas de elementos de madeira, é importante a correta consideração do modelo constitutivo e de sua ortotropia. Ademais, nas análises termoestruturais, é essencial considerar a redução das propriedades mecânicas da madeira com a elevação da temperatura. Assim, este trabalho foi desenvolvido no ABAQUS, um modelo numérico para representar vigas de madeira em situação de incêndio. Constatou-se que o modelo numérico foi capaz de representar com precisão o comportamento termoestrutural de vigas de madeira em situação de incêndio. A partir do modelo numérico validado foram realizados estudos paramétricos, sendo constatado que o fator de carregamento apresenta uma relação quadrática com o tempo de resistência ao fogo, enquanto a largura da seção transversal da viga apresenta uma relação cúbica com o tempo de resistência ao fogo. Foi observado também que diferentes formas de aquecimento interferem no comportamento das curvas de deslocamento vertical em função do tempo de incêndio das vigas de madeira submetidas ao fogo.
Laser Effect on a Pathologically Altered Capsule of the Lens of the Eye
Authors:   Institute of Photonic Technologies Federal State Institution “Research Center “Crystallography and Photonics” RAS, Baum Olga , Yuzhakov Alexey ,   Institute of Photonic Technologies Federal State Institution “Research Center “Crystallography and Photonics” RAS, Gamidov Alibek ,   Federal State Budgetary Scientific Institution “Research Institute of Eye Diseases”, Medvedeva Elena ,   Federal State Budgetary Scientific Institution “Research Institute of Eye Diseases”, Yusef Yusef ,   Federal State Budgetary Scientific Institution “Research Institute of Eye Diseases”
Published: July 2022

One of the current areas of application of lasers in ophthalmology is cataract surgery and reducing the number of negative reactions to surgical intervention. In the postoperative period, clouding of the lens capsular bag and the risk of contraction capsular syndrome associated with changes in the biomechanical properties of the lens and capsular bag system are often observed. In the work, the biomechanics of such system were studied. Lenses that were placed in a 10% formalin solution to create cataract-simulating opacity for various amounts of time were studied by optical-coherent tomography, speckle-interferometry method and with fiber-optics setup for scattering dynamics registration. It was shown that speckle interferometry technique is sensitive to structural changes of lenses due to formalin exposure, which makes tissue more elastic and less transparent. OCT shows the same result and is more sensitive to the changes of laser wavelength. In addition, theoretical studies were carried out and have shown that changing laser wavelength can be dangerous for the integrity of the capsule film during medical intervention due to increase of maximum thermal stress.
Optical Properties of Glycated and Non-Glycated Hemoglobin – Raman/Fluorescence Spectroscopy and Refractometry
Authors:   Science Medical Center, Saratov State University, Lazareva Ekaterina ,   Laboratory of Laser Molecular Imaging and Machine Learning, Zyubin Andrey ,   REC “Fundamental and Applied Photonics. Nanophotonics”, Immanuel Kant Baltic Federal University, Dikht Natalya ,   Saratov State Medical University named after V. I. Razumovsky, Bucharskaya Alla ,   Science Medical Center, Saratov State University,   Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University,   Saratov State Medical University named after V. I. Razumovsky, Samusev Ilya ,   REC “Fundamental and Applied Photonics. Nanophotonics”, Immanuel Kant Baltic Federal University, Slezhkin Vasily ,   REC “Fundamental and Applied Photonics. Nanophotonics”, Immanuel Kant Baltic Federal University,   Department of Chemistry, Kaliningrad State Technical University, Kochubey Vyacheslav ,   Science Medical Center, Saratov State University,   Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, Tuchin Valery ,   Science Medical Center, Saratov State University,   Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University,   Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control, FRC "Saratov Research Centre of the Russian Academy of Sciences"
Published: July 2022

In this study, the optical properties of glycated (HbA1c) and non-glycated (Hb) hemoglobin are compared using Surface-enhanced Raman spectroscopy (SERS), spectrofluorimetry, and refractometry. Analysis of the spectral shift of SERS spectra showed good discrimination between two hemoglobins indicating differences in their molecular structure. The fluorescence spectra measured at excitation wavelengths of 260, 270, and 280 nm also indicate differences in the molecular structure of these hemoglobins. For the first time refractive index temperature increments were measured for HbA1c in a wide wavelength range in the visible and NIR as –(1.35 ± 0.11) x 10–4 °C–1 and compared with normal hemoglobin (dn/dT = –(1.02 ± 0.12) x 10–4 °C–1). The comparison of temperature RI increments for hemoglobin obtained from the whole blood of healthy volunteers and diabetic patients is also done. The data obtained can serve as a basis for further study of the optical properties of glycated hemoglobin and other glycated proteins.
Jayabaya’s Vision in The Javanese Cosmology: Wise Religion, Herucokro Revelation and Black Pegasus
Authors: Rohman Saifur
Published: July 2022

The paper is to find out values, world view, and norm orientation in manuscript entitled Jayabaya  (without publising year) by G Rr Ay. Brotodiningrat and Primbon Pusaka Jawa Jangka Jayabaya Pranitiwakya by R Tanojo (without publising year). This study is needed because various research and publishing in the five late year have showed an interest with a history  of social context, viewing, and values.  Method of data collecting is close reading and method analysis is refers the phenomonelogy that stress on the concept of intensionality and extensionality. Intensionality means evidence that is showed by consciousness while extensionality refers to proof of external world. Result of this research is to prove the Javanese cosmology of harmony. It is need to live with concept harmonizing of which there are good relation with the other, environment, and the bigger cosmic in the human existence. Symbol in text of the Jangka Jayabaya, like Herucokro, Kuda Sembarni Hitam, Agama Budi, dan Hidup Harmoni, give a message of how to be a just leader, good norm, and developing a new social order.
Association of Innovation and Entrepreneurial Orientation on SME Performance: The Case of Soc Trang Province Vietnam
Authors: Binh Tu Van , Thy Ngo Giang , Vu Pham Minh , Khoa Huynh Dang , Thong Nguyen Dinh
Published: July 2022

Quantitative results derived by Extended Ordered Probit Model on 91 SMEs in Soc Trang province show the influential role of innovation and entrepreneurial orientation on the sales growth of enterprises. These two factors confirm their association is indispensable in the development of enterprises. In addition, the results also provide information on the significant contribution of endogenous variables in the model. Of which the application of information technology (IT) in the organizational administration is endogenous and contributes significantly to innovation and entrepreneurial orientation on SMEs performance, which the older SMEs are, the more interested they are in applying IT in the organizational administration. The finding is an important message for local SMEs who need to rethink the application of IT systems to corporate governance. It is also very useful reference information for local policymakers to create an approach that supports SMEs in developing innovation strategies and entrepreneurial orientation toward market integration.
On the Economic Impacts of Transportation Innovations: A Comprehensive Application to Quantifying the Impacts of an Hyperloop Technology
Authors: Buttlar William G , Haslag Joseph H
Published: July 2022

The purpose of this paper is to quantify the economic impacts associated with an investment in transportation systems. Here, we apply the methodology to projected comprehensive economic impacts of an Hyperloop route. The methodology is a low-frequency economic growth model that includes cumulative gains in real GDP, cost savings and the greenhouse gas savings of the proposed Hyperloop technology. To calibrate the model, we consider a route spanning from Texas to Chicago and covering 1,575 miles across the proposed hyperloop system. The infrastructure investment is obtained from construction cost estimates presented in previous feasibility studies. Our contribution is to present a simple general equilibrium approach to quantifying transportation economic impacts. To our knowledge, our is the first quantitative assessment of the Hyperloop technology. We include an analysis of the public finance aspects of the route, thus adding an answer to the question regarding the national merits of such an investment project. Our findings suggest that for returns comparable to the interstate highway system, the project could be paid for out of the stream of future tax revenues. There are additional gains through lower fares and travel times. Lastly, the environmental gains, especially from reduced air travel, are quantitatively significant.
The Most Important Future Challenges of Aging in Iran
Authors: Balochi Monire , Dehnavie Reza , Shati Mohsen , Imani Elahe , Kalavani Khalil
Published: July 2022

The Article Abstract is not available.
Building Stones of Resilience of Vulnerable Older Persons
Authors: Witte Jasper De , Regenmortel Tine Van
Published: July 2022

Introduction: Vulnerable older persons need sufficient resilience to deal with (age-related) adversities and safeguard their quality of life. In this study, we investigate which sources of strength vulnerable older persons use to deal adversities.
 
Methods: This qualitative study is based on fifteen narratives of community-dwelling vulnerable older persons in Belgium, who were selected through a ‘purposive sampling’ strategy.
 
Results: Vulnerable older persons use various interrelated sources of strength situated on the individual, interactional, and contextual domains. On the individual domain, important sources of strength are having an optimistic life view and accepting the own vulnerabilities. On the interactional domain positive social relations, ‘the power of giving’ and social participation are sources of strength that benefit the quality of life of older persons, and on the contextual domain various welfare benefits are essential.
 
Conclusion: It is crucial to stimulate those sources of strength, for example by removing contextual barriers that impede social participation. The results can guide empowering interventions that aim to reinforce the sources of strength of vulnerable older persons, which will positively affect their resilience and general well-being.
Evaluation of the Relationship Between Foreign Patients' Satisfaction and Financial Dimension, Treatment Quality, and Treatment and Tourism Facilities in Hospitals of Iran University of Medical Sciences
Authors: Najafipour Moghadam Fatemeh , Tavakoli Nader , Nemati Khadijeh , Pak Narges
Published: July 2022

Background: Medical tourism provides Effective economic, political and social profits to the countries active in the field, which should be taken into account in a competitive market. This study aimed to evaluate the relationship between foreign patients' satisfaction and other aspects of health tourism in educational and medical centers of the Iran University of Medical Sciences (IUMS).
Methods: This was a descriptive correlational study with a researcher-made questionnaire. The first part of the questionnaire contained the demographic characteristics of the participants, and the second part included 30 questions about the components that affect receiving medical services by foreign nations. The reliability coefficient of the questionnaire was determined by using Cronbach's alpha (0.980). Expert judgment was used to assess the validity of the questionnaire. Out of 70 hospitals affiliated with the University of Iran in 2019, 10 hospitals from 35 licensed centers in the field of international health were randomly selected, and 300 questionnaires were delivered to foreign patients who were willing to complete the questionnaire. The received information was from Random sampling recorded in SPSS25 software. Descriptive Statistics was used to determine the effective factors.  
Results: The largest numbers of foreign patients in this study were from Iraq (64 %) and Kuwait (24 %), respectively. In correlation review, there was a significant relationship between satisfaction of foreign patients and financial dimension (0.785), quality of treatment dimension (0.914), medical facilities dimension (0.799) and tourism facilities dimension (0.918) in hospitals.
Conclusion: This study demonstrates that there is a significant relationship between satisfaction of foreign patients and other aspects of health tourism (such as financial dimension, treatment quality, treatment and tourism facilities) in hospitals, Which needs to be given special attention by health tourism managers for short-term and long-term planning for its development.
Productivity Analysis of Medical Record Department in Hospitals Affiliated with Urmia University of Medical Sciences
Authors: Mokhtari Akram , Nabilou Bahram , Aghlmand Siamak , Yusefzadeh Hasan
Published: July 2022

Background: The importance of paying attention to improving productivity in different health system departments  has become increasingly evident. This is due to increased costs of health care goods and services, limited resources and production facilities. This study aims to measure the productivity of hospitals' Medical Records Departments (MRD) affiliated with Urmia University of Medical Sciences to provide a comprehensive analysis of their performance.
Methods: In this study, total productivity and total factor productivity changes of medical record departments in hospitals affiliated with Urmia University of Medical Sciences were calculated. This was conducted through Kendrick-Creamer and Malmquist indexes in 2016-2020, and has examined the trend of each one of them. Input variables included the number of personnel and equipment. Output variables encompassed the number of outpatient and inpatient medical records prepared for patients, responses to letters, and patients referred to the studied MRD. After estimating the production function, the elasticity of production factors and the return to the scale of medical record departments were calculated.Total productivity changes and production function were estimated via Deap2,1 and Frontier4,1 softwares by applying input minimization and variable returns to scale assumptions.
Results: The results of the Malmquist index indicated that the average total productivity changes of medical records departments of hospitals during the study period were equal to 1,096. This is greater than one; therefore, it can be concluded that productivity has decreased by about 9.600 % during the study period. Changes in technological efficiency have had the greatest impact on reducing productivity, to other factors. In addition, the results of Kendrick-Creamer index during the years under review demonstrated that the average total productivity of production factors obtained, was equal to 18725.530 services.
Conclusion: There is decreased productivity due to technological changes in the studied departments. This is because of the lack of sufficient knowledge of the medical records department staff in the use of technology and equipment for providing efficient services . Holding training courses for the appropriate use of technology by personnel can be useful in this regard.
Investigating the Relationship Between Management Style and Market Orientation in Qazvin University of Medical Sciences
Authors: Ahadinezhad Bahman , Khosravizadeh Omid , Vahdati Fatemeh , Mohammadkhani Mohammadreza , Soheylirad Rana , Sarikhani Sogol
Published: July 2022

Background: Hospital management style can affect various aspects of hospital performance. One of these aspects is the level of market orientation of the hospital. Therefore, the present study attempts to answer whether management style makes a difference in the degree market orientation of hospitals or not.
Methods: This research is a descriptive-analytical and cross-sectional study conducted in 2020. About 420 people were selected by stratified sampling out of the six medical centers' staff in Qazvin, Iran. A total of 411 people (97.86 %) completed the questionnaires. The collected data were analyzed using STATA15 and SPSS16 software. Robust regression analysis was used to estimate the role of management style in the level of market orientation of hospitals. Mean variables were analyzed using one-way analysis of variance and post hoc test.
Results: The score range of the variables was from 1 to 5. Autocratic and delegating styles obtained the highest average (3.22 ± 0.54) and the lowest average (2.87 ± 0.70), respectively. Among the dimensions of market orientation, customer orientation had the highest average (3.32 ± 0.84), while competitor orientation obtained the lowest average (2.80 ± 0.86). The average score of market orientation was 2.88 ± 0.65. A statistically significant difference between hospitals was observed in terms of participative and delegating styles (P-value < 0.05). In addition to market orientation, there was a statistically significant difference between hospitals (P-value < 0.05). The regression coefficient between the level of the hospital market orientation and the participative and delegating styles was 0.10 and 0.09, respectively (P-value < 0.05). In contrast, the regression coefficient between autocratic style and level of market orientation was estimated to be -0.76.
Conclusion: It can be concluded that managers should use more participatory and delegating styles to increase the market orientation of the studied hospitals.
Aspectos simbólicos de la enseñanza remota de emergencia en América Latina: una mirada desde los estudios organizacionales
Authors: Ramos Luna Lorena Litai , Cadena López Aydé
Published: July 2022

The pandemic caused by COVID-19 caused transformations in the social, economic, political, health, scientific and educational spheres, among others, which in turn generated new symbols and meanings that have redefined each area. Specifically, at the educational level, distance education is one of the fields where this transformation of the concepts that defined it has been most perceived and the rooting of new symbols or meanings that well deserve to be studied from a critical perspective. In this sense, the field of organizational studies offers a constructivist and transdisciplinary vision that allows the comprehensive understanding of these elements. Thus, the objective is to analyze the symbolic aspects of remote emergency education and how they have impacted on the reconfiguration of the higher education field since the COVID-19 pandemic. Based on a theoretical analysis, the main contribution is to identify certain symbols and meanings that have changed the concept of higher education: the recognition of distance education and digital resources as main tools for education; the need for hybrid models and mixed learning; the shaping of new challenges for students, teachers and educational institutions.
Keywords: COVID-19; Higher education; Organizational studies; Distance remote teaching; Symbols and meanings.
Cuando administración y cultura corporativa no son suficientes para la Gestión Escolar: una evidencia empírica.
Authors: Jiménez-Herrera Julio
Published: July 2022

This research about sustainable development and its relationship with corporate culture was developed in a medium-sized city in the south of Mexico, Veracruz. The objective of this work is to find a comprehensive-interpretative explanation of the phenomenon studied to evidence the relationships that are established between the administrative discourse (management), the organizational culture and some elements of sustainable development. This research was developed under a qualitative modality and were used as techniques for the collection of information, individual and semi-structured interviews that were recorded and later transcribed for analysis. It presents the case of a school where despite de efforts made by the organizational actors (director, students, secretary, professors and parents) to make their school a sustainable organization, fundamental controversies are observed between what was planned and executed (administration), with he values, believes and the meanings that the actors give to the care of the resources inside the institution ( organizational culture) in terms of inhibit the waste of the electric energy, the water, and the non-assumption of the ecological habits to develop and maintain the green areas of the school. 
Keywords: Administration; Culture; Organization; Sustainable; School management
La desigualdad social desde la dominación simbólica en las instituciones públicas y privadas
Authors: Herrera Martell Jessica , Herrera Caballero Juan Manuel , Martell Martínez Norma Georgina
Published: July 2022

One of the greatest challenges within the social sciences is to show the inequality that exists within educational organizations and institutions, which in this work will be analyzed from the interpretation of the microcosms (Habitus, Field, Capitals) of Pierre Bourdieu , which derive in a symbolic domination that is promoted in relation to the attached school to which the students belong, whether it is a public or private institution, as well as showing some of the elements that contribute to social inequality, through the mechanisms who collaborate in the reproduction of the same, derived from the capitals that individuals possess; The referential frameworks within the OS have left us a path in the conformation of the investigations within this field; Going back to Bourdieu in the study of organizations, not only implies carrying out the analysis of their categories, but also the understanding of these phenomena from a less functional sense, which focuses on the symbolic and the subjective, starting from the different rationalities of the OE, from a symbolic-interpretive approach, through the formation of capitals and in the conformation of field theory, to later show the reproduction of Bourdieu and Passeron.
Keywords: Symbolic domination; education; inequality; social capital; subjetivity
Actividad antimicrobiana del aceite esencial del kion (Zingiber officinale) sobre cepas de Streptococcus causantes de linfadenitis cervical en cuyes
Authors: Krklec Torres Sandra , Morales-Cauti Siever
Published: July 2022

El objetivo del estudio fue determinar el efecto antimicrobiano del aceite esencial del kion (Zingiber officinale) sobre cepas de Streptococcus causantes de linfadenitis cervical en cuyes (Cavia porcellus). El aceite esencial de kion se obtuvo a través de la destilación por arrastre de vapor, logrando un rendimiento de 0,06%, donde el componente mayoritario fue α-Citral (21,11%). Se recolectaron abscesos de animales con diagnóstico positivo a linfadenitis cervical provenientes de granjas comerciales. Se identificaron y aislaron 20 cepas de casos clínicos, 16 de Streptococcus pyogenes y 4 de Streptococcus equi subsp zooepidemicus. Se trabajó con cuatro concentraciones (65, 45, 25 y 5%) del aceite esencial y tres repeticiones por cada cepa aislada. El mayor diámetro de halo de inhibición en promedio fue 15,12 mm y 14,73 mm para cepas de S. pyogenes y S. equi subsp zooepidemicus en la concentración al 65% con un valor de sensibilidad límite (SL) y sensibilidad media (SM), respectivamente según la escala Duraffourd et al. (1986); mientras que las concentraciones del 25 y 45% tuvieron un valor de SL de 9,53 mm y 12,19 mm para S. pyogenes; en tanto valores promedio de 9,93 mm y 12,81 mm para S. equi spp zooepidemicus. El aceite esencial del kion presenta actividad antimicrobiana in vitro frente a cepas S. pyogenes y S. equi subsp zooepidemicus.