bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermal Stress Simulation and Structure Failure Analyses of Nitrogen–Oxygen Sensors under a Gradual Temperature Field
Authors: Feng Jiangtao , Geng Jiaqi , She Hangyu , Zhang Tao , Chi Bo , Pu Jian
Published: April 2022

Nitrogen–oxygen sensors are pivotal for NOX emission detection, and they have been designed as key components in vehicles’ exhaust systems. However, severe thermal stress concentrations during thermal cycling in the sensors create knotty structural damage issues, which are inevitable during the frequent start–stop events of the vehicles. Herein, to illustrate the effect of thermal concentration on a sensor’s structure, we simulated the temperature and stress field of a sensor through finite element analysis. The failure modes of the sensor based on the multilayer structure model were analyzed. Our simulation indicated that the thermal deformation and stress of the sensors increased significantly when the heating temperature in the sensors increased from 200 to 800 °C. High stress regions were located at the joint between the layers and the right angle of the air chamber. These results are consistent with the sensor failure locations that were observed by SEM, and the sensor’s failures mainly manifested in the form of cracks and delamination. The results suggest that both the multilayer interfaces and the shape of the air chamber could be optimized to reduce the thermal stress concentrations of the sensors. It is beneficial to improve the reliability of the sensor under thermal cycling operation.
A Hybrid Multi-Criteria-Decision-Making Aggregation Method and Geographic Information System for Selecting Optimal Solar Power Plants in Iran
Authors: Heidary Dahooie Jalil , Husseinzadeh Kashan Ali , Shoaei Naeini Zahra , Vanaki Amir Salar , Zavadskas Edmundas Kazimieras , Turskis Zenonas
Published: April 2022

Policy-makers should focus on solar energy due to the increasing energy demand and adverse consequences such as global warming. Conflicting criteria influence choosing the most desirable place to construct a Solar Power Plant (SPP). Researchers have popularized multicriteria decision-making (MCDM) methods because of the potential. Although the simultaneous use of several methods increases the robustness and accuracy of the results, existing methods to integrate MCDM methods mainly consider the same weight for all methods and utilize the alternatives ranking for the final comparison. This paper presents a hybrid decision-making framework to determine the best location for SPPs in Iran using a set of criteria extracted from the literature and expert opinions. An initial list of decision-making alternatives is prepared and evaluated using GIS software in terms of criteria. Decision-makers prioritized the identified alternatives using the MCDM methods, including SWARA and different ranking methods (TOPSIS, TODIM, WASPAS, COPRAS, ARAS, and MULTIMOORA). Finally, the CCSD method aggregates the results and identifies the best location. Results highly correlate with the results of previous methods and demonstrate the robustness of the proposed approach and its capability to overcome the limitations of previous methods.
Extending the Local Convergence of a Seventh Convergence Order Method without Derivatives
Authors: Argyros Ioannis K. , Sharma Debasis , Argyros Christopher I. , Parhi Sanjaya Kumar
Published: April 2022

For the purpose of obtaining solutions to Banach-space-valued nonlinear models, we offer a new extended analysis of the local convergence result for a seventh-order iterative approach without derivatives. Existing studies have used assumptions up to the eighth derivative to demonstrate its convergence. However, in our convergence theory, we only use the first derivative. Thus, in contrast to previously derived results, we obtain conclusions on calculable error estimates, convergence radius, and uniqueness region for the solution. As a result, we are able to broaden the utility of this efficient method. In addition, the convergence regions of this scheme for solving polynomial equations with complex coefficients are illustrated using the attraction basin approach. This study is concluded with the validation of our convergence result on application problems.
Generalization of k-Uniformly Starlike and Convex Functions Using q-Difference Operator
Authors: Ali Irfan , Malghani Yousaf Ali Khan , Hussain Sardar Muhammad , Khan Nazar , Ro Jong-Suk
Published: April 2022

In this article we have defined two new subclasses of analytic functions k−Sq[A,B] and k−Kq[A,B] by using q-difference operator in an open unit disk. Furthermore, the necessary and sufficient conditions along with certain other useful properties of these newly defined subclasses have been calculated by using q-difference operator.
Design and High-Order Precision Numerical Implementation of Fractional-Order PI Controller for PMSM Speed System Based on FPGA
Authors: Wang Baokun , Wang Shaohua , Peng Yibing , Pi Youguo , Luo Ying
Published: April 2022

In this paper, the design of a fractional-order proportional integral (FOPI) controller and integer-order (IOPI) controller are compared for the permanent magnet synchronous motor (PMSM) speed regulation system. A high-precision implementation method of a fractional-order proportional integral (FOPI) controller is proposed in this work. Three commonly used numerical implementation methods of fractional operators are investigated and compared for comprehensively evaluating the numerical implementation performance in this work. Furthermore, for the impulse response invariant implementation method, the effects of different discretization orders on the control performance of the system are compared. The high-order fractional-order controller can be implemented accurately in a control system with the field-programmable gate array (FPGA) with the capability of parallel calculation. The simulation and experimental results show that the high-precision numerical implementation method of the designed high-order FOPI controller has better performance than the ordinary precision fractional operation implementation method and traditional order integer order PI controller.
Circular Economy of Coal Fly Ash and Silica Geothermal for Green Geopolymer: Characteristic and Kinetic Study
Authors: Petrus Himawan Tri Bayu Murti , Olvianas Muhammad , Shafiyurrahman Muhammad Faiz , Pratama I Gusti Agung Arvin Nanda , Jenie Siti Nurul Aisyiyah , Astuti Widi , Nurpratama Muhammad Istiawan , Ekaputri Januarti Jaya , Anggara Ferian
Published: April 2022

The study of geopolymers has become an interesting concern for many scientists, especially in the infrastructure sector, due to having inherently environmentally friendly properties and fewer energy requirements in production processes. Geopolymer attracts many scientists to develop practical synthesis methods, useful in industrial-scale applications as supplementary material for concrete. This study investigates the geopolymerization of fly ash and geothermal silica-based dry activator. The dry activator was synthesized between NaOH and silica geothermal sludge through the calcination process. Then, the geopolymer mortar was produced by mixing the fly ash and dry activator with a 4:1 (wt./wt.) ratio. After mixing homogeneously and forming a paste, the casted paste moved on to the drying process, with temperature variations of 30, 60, and 90 °C and curing times of 1, 3, 5, 7, 14, 21, 28 days. The compressive strength test was carried out at each curing time to determine the geopolymer’s strength evolution and simulate the reaction’s kinetics. In addition, ATR-FTIR spectroscopy was also used to observe aluminosilicate bonds’ formation. The higher the temperature, the higher the compressive strength value, reaching 22.7 MPa at 90 °C. A Third-order model was found to have the highest R2 value of 0.92, with the collision frequency and activation energy values of 1.1171 day−1 and 3.8336 kJ/mol, respectively. The utilization of coal fly ash and silica geothermal sludge as a dry activator is, indeed, an approach to realize the circular economy in electrical power generations.
Synergistic Interaction and Binding Efficiency of Tetracaine Hydrochloride (Anesthetic Drug) with Anionic Surfactants in the Presence of NaCl Solution Using Surface Tension and UV–Visible Spectroscopic Methods
Authors: Azum Naved , Rub Malik Abdul , Khan Anish , Alotaibi Maha M. , Asiri Abdullah M.
Published: April 2022

Surfactants are ubiquitous materials that are used in diverse formulations of various products. For instance, they improve the formulation of gel by improving its wetting and rheological properties. Here, we describe the effects of anionic surfactants on an anesthetic drug, tetracaine hydrochloride (TCH), in NaCl solution with tensiometry and UV–visible techniques. Various micellar, interfacial, and thermodynamic parameters were estimated. The outputs were examined by using different theoretical models to attain a profound knowledge of drug–surfactant mixtures. The presence of attractive interactions among drug and surfactant monomers (synergism) in mixed micelle was inferred. However, it was found that sodium dodecyl sulfate (SDS) showed greater interactions with the drug in comparison to sodium lauryl sarcosine (SLS). The binding of the drug with surfactants was monitored with a spectroscopic technique (UV–visible spectra). The results of this study could help optimize the compositions of these mixed aggregates and find the synergism between monomers of different used amphiphiles.
Differences in the Glenohumeral Joint before and after Unilateral Breast Cancer Surgery: Motion Capture Analysis
Authors: García-González Silvia Beatríz , Huerta-Franco María Raquel , Miguel-Andrés Israel , de Jesús Mayagoitia-Vázquez José , León-Rodríguez Miguel , Barrera-Beltrán Karla , Espinoza-Macías Gilberto
Published: April 2022

After mastectomy, women might lose mobility and develop kinematic changes in the shoulder. The objective of this research was to compare the kinematics of the glenohumeral joint in women, before and after unilateral breast cancer surgery. This was a longitudinal study with a pre- and post-evaluation design; in total, 15 Mexican women who had a mastectomy for breast cancer and who received a physical therapy program after surgery were evaluated. Flexion–extension and abduction–adduction movements of the glenohumeral joint were evaluated (15 days before and 60 days after mastectomy). For the kinematic analysis of the glenohumeral joint, an optoelectronic motion capture system was used to monitor 41 reflective markers located in anatomical landmarks. There was no significant difference in the range of motion of the glenohumeral joint when comparing pre- and post-mastectomy, flexion–extension (p = 0.138), and abduction–adduction (p = 0.058). Furthermore, patients who received chemotherapy (53%) before mastectomy were more affected (lower range of motion) than those who did not receive it. There were no significant differences in the kinematics of the glenohumeral joint after mastectomy in this group of patients who received a physical therapy program after surgery. Moreover, patients who received chemotherapy treatment before breast cancer surgery tended to have a lower range of motion than those who did not receive it. Therefore, it is necessary for the physical rehabilitation team to attend to these patients even before the mastectomy.
Frontline Healthcare Professionals’ Views Regarding the Impact of COVID-19 on Ethical Decision-Making: A Multicentre Mixed-Methods Study from Estonia
Authors: Simm Kadri , Zameska Jay , Lubi Kadi
Published: April 2022

Background: The objective of the study was to investigate frontline healthcare professionals’ experiences and attitudes in relation to the COVID-19 pandemic’s ethical and psychosocial aspects in Estonia. There were two research foci: first, ethical decision-making related to treating patients in the context of potential medical resource scarcity, and second, other psychosocial factors for healthcare professionals pertaining to coping, role conflicts, and the availability of institutional support. Methods: An online survey was conducted in the fall of 2020 amongst the frontline healthcare professionals working in the three most impacted hospitals; respondents were also drawn from two ambulance services. The focus of the survey was on the first wave of COVID-19 (spring 2020). A total of 215 respondents completed the quantitative survey and qualitative data were gathered from open comments. Results: Over half of the surveyed healthcare professionals in Estonia expressed confidence in their roles during the pandemic. More than half cited the complex ethical aspects related to their decisions as their main source of doubt and uncertainty. In response to this uncertainty, Estonian healthcare professionals drew on their previous training and experience, the policies and guidelines of their institution, and support from their colleagues, to aid their decision-making during the pandemic. Conclusions: Although frontline healthcare professionals faced difficult decisions during the first wave of the pandemic, overall, most agreed that experiencing the pandemic reconfirmed that their work mattered greatly.
Fungal and Oomycete Diseases of Minor Tropical Fruit Crops
Authors: Zakaria Latiffah
Published: April 2022

Minor tropical fruits are grown on a small scale and provide income to smallholder farmers. The cultivation of these fruit crops indirectly contributes to the economy of producing countries as well as to food and crop security. Dragon fruits, guava, passionfruit, lychee, longan, mangosteen, durian, and rambutan are common minor fruit crops. In recent years, the international trade of some of these minor tropical fruits, particularly dragon fruit, passionfruit, guava, and lychee, has increased due to their nutritional value, with various health benefits. Similar to other crops, minor fruit crops are susceptible to fungal and oomycete diseases. These diseases negatively affect the yield and quality of fruit crops, leading to substantial losses. In this context, the knowledge of disease types and causal pathogens is fundamental to develop suitable disease management practices in the field as well as appropriate post-harvest treatments.
Physiological and Biochemical Adaptive Traits in Leaves of Four Citrus Species Grown in an Italian Charterhouse
Authors: Curadi Maurizio , Marchioni Ilaria , Mancino Matteo , Pistelli Luisa , Pistelli Laura , Scartazza Andrea
Published: April 2022

Citrus trees are a very important crops that are cultivated worldwide, but not much knowledge is known about the ecophysiological responses to climatic changes in trees under natural conditions. The aim of this study was to investigate their adaptive capacity in response to seasonal phenological and environmental changes. The trial included Citrus trees (sweet orange, bitter orange, lemon, mandarin) growing under non-regular cropping conditions in a Monumental Charterhouse in Tuscany, in a subtropical Mediterranean climate with hot summer conditions. During a 1-year field trial, we determined the variations in chlorophyll fluorescence parameters and leaf biochemical traits (content of chlorophylls and carotenoids, total phenolic content (TPC), total antioxidant capacity (TAC), and total non-structural carbohydrates). In all Citrus spp., interspecific mean values of photochemical efficiency peaked during the summer, while a marked photoinhibition occurred in the winter in concomitance with higher interspecific mean values of leaf TPC, TAC, and non-structural carbohydrates. The trees showed the pivotal role played by photosynthetic acclimation as a survival strategy to tolerate abiotic stress in the climate change hotspot of Mediterranean environment. This study is included in a wider project aimed at a new valorization of Citrus trees as genetic resource and its by-products with added-value applications for innovative functional foods.
Soundscape Evaluation Outside a Taoist Temple: A Case Study of Laojundong Temple in Chongqing, China
Authors: Xie Hui , Peng Zhaohui , Kang Jian , Liu Chang , Wu Huifei
Published: April 2022

The unique architectural form and religious background of Taoist buildings can lead to a special acoustic environment, but there is a lack of research on the soundscape evaluation of Taoist buildings. Laojundong Taoist Temple was selected as the research site. The psychological and physiological responses of Taoist priests and ordinary people, and strategies for soundscape renovation were investigated by conducting field measurements, interviews, soundwalks, and audio–visual experiments. There was significant negative linear regression between the LAeq,5min and soundscape comfort (p < 0.01). The visual landscape comfort of ordinary people was notably correlated with landscape diversity (p < 0.01), whereas their soundscape comfort was markedly correlated with the degree of natural soundscape and audio–visual harmony (p < 0.01). The soundscape evaluation by Taoist priests was affected by their belief, activity types, social factors, and spatial positions. With the increasing proportion of the natural elements in the visual landscape in the temple, the acoustic comfort of Taoist priests and ordinary people significantly increased with the addition of bird sounds (p < 0.01). However, with the increasing proportion of Taoist scenes, Taoist music only significantly improved the acoustic comfort and heart rate of ordinary people (p < 0.01).
Impacts of National Drug Price Negotiation on Expenditure, Volume, and Availability of Targeted Anti-Cancer Drugs in China: An Interrupted Time Series Analysis
Authors: Sun Yan , Zhu Zheng , Zhang Jiawei , Han Peien , Qi Yu , Wang Xiaoyang , Yang Li
Published: April 2022

The Chinese government has launched six rounds of national drug price negotiation since 2016 to lower the price and expand access to innovative drugs, many of which are anticancer drugs. This study aims to examine the effect of the second round of negotiation at the provincial level on the expenditure, volume, and availability of anti-cancer drugs. Procurement data at the provincial level from January 2017 to September 2018 were extracted from the China Drug Supply Information Platform (CDSIP). The volume, expenditure, and availability of three targeted anti-cancer drugs, rituximab, trastuzumab, and recombinant human endostatin (RHE), in 11 provinces that implemented the policy in September 2017 were analyzed through a controlled interrupted time series (ITS) analysis. A significant 6.0% increase (p < 0.1) in monthly average expenditure, an increase in the volume of 99.51 DDDs (defined daily doses) (p < 0.1), and a 0.24% (p < 0.1) increase in availability were observed for rituximab following the implementation of the policy. The volume and availability of rituximab increased by 949.6 DDDs (p < 0.05) and 1.56%, respectively, immediately after implementation. The availability of trastuzumab increased by 5.14% (p < 0.01) immediately after the implementation while no instant changes in expenditure and volume were observed. A 15% (p < 0.01) increase in monthly expenditure, 3673.17 DDDs increase in volume, and 0.66% increase in availability were observed after the inclusion of Trastuzumab. However, for RHE, only a 0.32% (p < 0.01) increase was observed after its inclusion. Eastern and middle provinces benefited more than western provinces. National negotiation related to the drug price significantly increased the volume and expenditure of anti-cancer drugs and improved their availability. The effect of the policy might be different across different regions and across different anticancer drugs.
Screening Children for Autism Spectrum Disorders in Low- and Middle-Income Countries: Experiences from the Kurdistan Region of Iraq
Authors: Samadi Sayyed Ali , McConkey Roy , Nuri Hana , Abdullah Amir , Ahmad Lizan , Abdalla Barez , Biçak Cemal A.
Published: April 2022

Screening tools for the early identification of developmental disabilities are strongly advised, yet culturally valid tools are not readily available for use in low- and middle-income countries. The present study describes the context and the processes used to develop a suitable screening procedure for use in the Kurdistan region of Iraq. This was based on an autism rating scale—GARS-3—developed in the USA for use primarily with children’s parents. It was administered to three groups of children: those with a pre-existing diagnosis of ASD; those with a confirmed diagnosis of a developmental disability; and those who were typically developing—735 participants in all. The 10 items from the 58 items in the full GARS-3 scale that best discriminated the three groups of children were identified. Subsequent analysis confirmed that the ten-item summary scores had reasonable internal reliabilities, with a good specificity and sensitivity in distinguishing children with ASD from those that were typically developing but less so for children with other developmental disabilities. The study confirms the universality of autism symptoms but also the different emphasis Kurdish parents may place on them. Nevertheless, screening procedures need to be developed in the context of support services that can undertake follow-up diagnostic assessments and provide suitable interventions for use by parents to promote their child’s development. The study provides an example of how this can be possible in low- and middle-income countries.
Investigating the Challenges and Benefits of Engaging in Peer Support via Videoconferencing for People with Spinal Cord Injury
Authors: Barclay Linda , Lalor Aislinn
Published: April 2022

Background: One of the greatest challenges faced by people following a spinal cord injury is reintegrating into the community. Peer mentors are people who have had shared experiences of disadvantage and distress and have successfully navigated their way through the associated challenges to lead meaningful lives. Historically, peer mentoring services have been predominantly delivered via face-to-face interactions. Little is known about the experience of people with spinal cord injury engaging in online peer support services, and what the challenges and benefits are of this mode of delivery. Methods: An anonymous online survey consisting of closed and open response questions was used to collect data. Quantitative data were analysed descriptively and qualitative data were analysed using inductive content analysis. Results: Positive benefits of engaging in peer support via videoconferencing included convenience and social connectedness. The main barriers were problems with Wi-Fi and internet connections, inconsistencies between platforms and having to learn new platforms. Even though responses were mixed when comparing videoconferencing to face-to-face peer support, most participants felt socially connected. Conclusions: Addressing barriers through the provision of appropriate technology, and targeted and individualised assistance, is important to facilitate uptake of online peer support for people with spinal cord injury.
A Protocol for a Mixed-Methods Process Evaluation of a Local Population Health Management System to Reduce Inequities in COVID-19 Vaccination Uptake
Authors: Watson Georgia , Moore Cassie , Aspinal Fiona , Boa Claudette , Edeki Vusi , Hutchings Andrew , Raine Rosalind , Sheringham Jessica
Published: April 2022

Population health management is an emerging technique to link and analyse patient data across several organisations in order to identify population needs and plan care. It is increasingly used in England and has become more important as health policy has sought to drive greater integration across health and care organisations. This protocol describes a mixed-methods process evaluation of an innovative population health management system in North Central London, England, serving a population of 1.5 million. It focuses on how staff have used a specific tool within North Central London’s population health management system designed to reduce inequities in COVID-19 vaccination. The COVID-19 vaccination Dashboard was first deployed from December 2020 and enables staff in North London to view variations in the uptake of COVID-19 vaccinations by population characteristics in near real-time. The evaluation will combine interviews with clinical and non-clinical staff with staff usage analytics, including the volume and frequency of staff Dashboard views, to describe the tool’s reach and identify possible mechanisms of impact. While seeking to provide timely insights to optimise the design of population health management tools in North Central London, it also seeks to provide longer term transferable learning on methods to evaluate population health management systems.
The Cause of China’s Haze Pollution: City Level Evidence Based on the Extended STIRPAT Model
Authors: Li Jingyuan , Cheng Jinhua , Wen Yang , Cheng Jingyu , Ma Zhong , Hu Peiqi , Jiang Shurui
Published: April 2022

Based on the extended STIRPAT model, this paper examines social and economic factors regarding PM2.5 concentration intensity in 255 Chinese cities from 2007 to 2016, and includes quantile regressions to analyze the different effects of these factors among cities of various sizes. The results indicate that: (1) during 2007–2016, urban PM2.5 concentration exhibited declining trends in fluctuations concerning the development of the urban economy, accompanied by uncertainty under different city types; (2) population size has a significant effect on propelling PM2.5 concentration; (3) the effect of structure reformation on PM2.5 concentration is evident among cities with different populations and levels of economic development; and (4) foreign investment and scientific technology can significantly reduce PM2.5 emission concentration in cities. Accordingly, local governments not only endeavor to further control population size, but should implement a recycling economy, and devise a viable urban industrial structure. The city governance policies for PM2.5 concentration reduction require re-classification according to different population scales. Cities with large populations (i.e., over 10 million) should consider reducing their energy consumption. Medium population-sized cities (between 1 million and 10 million) should indeed implement effective population (density) control policies, while cities with small populations (less than 1 million) should focus on promoting sustainable urban development to stop environmental pollution from secondary industry sources.
A Critical Analysis of the Impact of Pandemic on China’s Electricity Usage Patterns and the Global Development of Renewable Energy
Authors: Mastoi Muhammad Shahid , Munir Hafiz Mudassir , Zhuang Shenxian , Hassan Mannan , Usman Muhammad , Alahmadi Ahmad , Alamri Basem
Published: April 2022

The COVID-19 pandemic has impacted economic activity in numerous sectors due to multiple forms of disruption, including border closures, a stay-at-home policy, and social isolation; the electricity consumption trends in this region will undoubtedly improve. This article examines the impact of COVID-19 on electricity generation and consumption in China during the first two quarters (Q1–Q2) of 2020 and 2021. Furthermore, several governments’ perspectives on COVID-19’s implications for renewable energy development, notably offshore wind power and solar photovoltaics (PV), were examined. Results of this article show that COVID-19 impacts the power industry. According to the analysis, during the first two quarters of 2020, the amount of electricity generated and consumed by China decreased by 1.4 and 1.3 percent, respectively, the capacity of the power plants increased by 5.3 GW and coal consumption dropped by 3.6 g/kWh. Investments in the power generation sector increased by 51.5 billion yuan and investment in the power grid grew by 0.7 billion. Additionally, new generation capacity decreased by 378 GW during the first two quarters of 2020. During the first two quarters of 2021, electricity consumption and production grew by 13.7 and 16.2 percent, respectively. Power plants’ capacity increased by 9.5 GW, while coal consumption for power supply fell by 0.8 g/kWh. The investment in power generation projects increased by 8.9 billion, while investment in power grid projects increased by 4.7 billion. Compared to last year’s same period, 14.92 GW of new capacity was installed. Due to lockdown measures, such as studying at home or working at home, domestic power use in the first two quarters of 2020–2021 increased by 6.6 and 4.5 percent, respectively. To minimize COVID-19’s impact on renewable energy development and assist in building offshore wind power plants, economic and financial measures have been put in place to reduce the epidemic’s effect on solar PV systems.
Determinants of Satisfaction with Solid Waste Management Services: A Central–Local Comparison in China
Authors: Wang Aiqin , Chen Xuyang , Wang Xu , Wei Jia , Song Liying
Published: April 2022

The Chinese central government proclaimed a mandatory or demonstration waste separation policy in some cities or counties to manage the increasing amounts of generated waste since 2017. Many cities and regions have also begun to build waste separation management systems and institutions, and community managers have created waste management rules and provided separation management services under the guidance of local government. However, little is known about how these policies or services have performed and the degree of residents’ satisfaction, especially regarding the central government. Therefore, the purpose of this study was to analyze the consequence of these policies using residents’ community and national satisfaction levels with solid waste management services (SWMS) and their determinants. An online survey in 2021 showed that the overall satisfaction levels of communities and national SWMS are similar, but the differences between rural and urban regions are significant. Residents’ satisfaction with community SWMS in urban regions was higher than national satisfaction, and the results in rural regions was contrary. The determinants of community and national satisfaction were also different and varied by region. To improve satisfaction, the government need to standardize basic management systems in different types of regions, gradually improve management services and institutions in rural areas and non-pilot cities and provide special services or facilities for less healthy residents.
A Cross-Sectional Survey on the Association between Dental Health Conditions and University Personality Inventory Scores among University Students: A Single-Center Study in Japan
Authors: Ishikawa Shigeo , Makino Naohiko , Togashi Hitoshi , Ito Nanami , Tsuya Atsushi , Hayasaka Makiko , Konta Tsuneo , Okuyama Naoki , Yusa Kazuyuki , Iino Mitsuyoshi
Published: April 2022

This study examined the association between dental health conditions and scores on the University Personality Inventory (UPI) among university students in Japan. Participants were freshmen at Yamagata University between 2010 and 2019. Dental check-ups, including dental caries, periodontal disease, malocclusion, and temporomandibular disorders (TMD), and mental health screening using the UPI were performed; 12,433 students were included in the final analysis. A logistic regression analysis was performed to confirm the association between dental health conditions and >30 UPI scores, which indicate the need to consult mental health professionals. Overall, students who required treatment for TMD had a 3.165-fold higher risk of >30 UPI scores (OR = 3.165, 95% CI = 1.710–5.857). Periodontal disease and TMD in male participants (periodontal disease: OR = 1.329, 95% CI = 1.108–1.595; TMD: OR = 3.014, 95% CI = 1.107–8.204) and TMD in female participants (OR = 2.938, 95% CI = 1.340–6.445) were significant risk factors for >30 UPI scores. Students requiring treatment for TMD were at risk of obtaining >30 UPI scores. Although our study has several limitations, students with subjective symptoms (e.g., disturbance in opening the mouth) should take the UPI test or in some cases consult mental health professionals.
A Tourist Behavior Analysis Framework Guided by Geo-Information Tupu Theory and Its Application in Dengfeng City, China
Authors: Tian Zhihui , Liu Yi , Wang Yongji , Wu Lili
Published: April 2022

With the development of tourism and the change in urban functions, the analysis of the spatial pattern of urban tourist flows has become increasingly important. Existing studies have explored and analyzed tourist behavior well, using the appropriate digital footprint data and research methods. However, most studies have ignored internal mechanisms analysis and tourism decision making. This paper proposed a novel framework for tourist behavior analysis inspired by geo-information Tupu, including three modules of the spatiotemporal database, symptom, diagnosis, and implementation. The spatiotemporal database module is mainly used for data acquisition and data cleaning of the digital footprint of tourists. The symptom module is mainly used for revealing the spatial patterns and network structures of tourist flows. The diagnosis and implementation module is mainly used for internal mechanism analysis and tourism decision making under different tourist flow patterns. This paper applied the proposed research framework to Dengfeng City, China, using online travel diaries as the source of digital footprint data, to analyze its tourist behavior. The results were as follows: tourist flows of Dengfeng were unevenly distributed, thus forming an obvious core–periphery structure with intense internal competition and unbalanced power. The difference in tourism resources between its northern and southern areas remains a challenge for future tourism development in Dengfeng.
Automatic Positioning of Street Objects Based on Self-Adaptive Constrained Line of Bearing from Street-View Images
Authors: Li Guannan , Lu Xiu , Lin Bingxian , Zhou Liangchen , Lv Guonian
Published: April 2022

In order to realize the management of various street objects in smart cities and smart transportation, it is very important to determine their geolocation. Current positioning methods of street-view images based on mobile mapping systems (MMSs) mainly rely on depth data or image feature matching. However, auxiliary data increase the cost of data acquisition, and image features are difficult to apply to MMS data with low overlap. A positioning method based on threshold-constrained line of bearing (LOB) overcomes the above problems, but threshold selection depends on specific data and scenes and is not universal. In this paper, we propose the idea of divide–conquer based on the positioning method of LOB. The area to be calculated is adaptively divided by the driving trajectory of the MMS, which constrains the effective range of LOB and reduces the unnecessary calculation cost. This method achieves reasonable screening of the positioning results within range without introducing other auxiliary data, which improves the computing efficiency and the geographic positioning accuracy. Yincun town, Changzhou City, China, was used as the experimental area, and pole-like objects were used as research objects to test the proposed method. The results show that the 6104 pole-like objects obtained through object detection realized by deep learning are mapped as LOBs, and high-precision geographic positioning of pole-like objects is realized through region division and self-adaptive constraints (recall rate, 93%; accuracy rate, 96%). Compared with the existing positioning methods based on LOB, the positioning accuracy of the proposed method is higher, and the threshold value is self-adaptive to various road scenes.
Conformational Changes in the BSA-LT4 Complex Induced by the Presence of Vitamins: Spectroscopic Approach and Molecular Docking
Authors: Cazacu Nicoleta , Chilom Claudia G. , David Melinda , Florescu Monica
Published: April 2022

Levothyroxine (LT4) is known for its use in various conditions including hypothyroidism. LT4 interaction with serum albumin may be influenced by the presence of vitamins. For this reason, we investigated the effect of vitamin C, vitamin B12, and folic acid on the complex of Bovine Serum Albumin with LT4 (BSA-LT4). UV-Vis spectroscopy was used to monitor the influence of vitamins on the BSA-LT4 complex. Fluorescence spectroscopy revealed a static quenching mechanism of the fluorescence of BSA-LT4 complex by the vitamin C and folic acid and a combined mechanism for vitamin B12. The interaction of vitamin C and folic acid with BSA-LT4 was moderate, while the binding of vitamin B12 was much stronger, extending the storage time of LT4 in blood plasma. Synchronous fluorescence found that the vitamins were closer to the vicinity of Trp than to Tyr and the effect was more pronounced for the binding of vitamin B12. The thermal stability of the BSA-LT4 complex was more evident, but no influence on the stability of BSA-LT4 complex was obtained for vitamin C. Molecular docking studies showed that vitamin C and folic acid bound the same site of the protein, while vitamin B12 bonded to a different site.
Convolutional Neural Networks for Mechanistic Driver Detection in Atrial Fibrillation
Authors: Ríos-Muñoz Gonzalo Ricardo , Fernández-Avilés Francisco , Arenal Ángel
Published: April 2022

The maintaining and initiating mechanisms of atrial fibrillation (AF) remain controversial. Deep learning is emerging as a powerful tool to better understand AF and improve its treatment, which remains suboptimal. This paper aims to provide a solution to automatically identify rotational activity drivers in endocardial electrograms (EGMs) with convolutional recurrent neural networks (CRNNs). The CRNN model was compared with two other state-of-the-art methods (SimpleCNN and attention-based time-incremental convolutional neural network (ATI-CNN)) for different input signals (unipolar EGMs, bipolar EGMs, and unipolar local activation times), sampling frequencies, and signal lengths. The proposed CRNN obtained a detection score based on the Matthews correlation coefficient of 0.680, an ATI-CNN score of 0.401, and a SimpleCNN score of 0.118, with bipolar EGMs as input signals exhibiting better overall performance. In terms of signal length and sampling frequency, no significant differences were found. The proposed architecture opens the way for new ablation strategies and driver detection methods to better understand the AF problem and its treatment.
Vitamin D and Ocular Diseases: A Systematic Review
Authors: Chan Hei-Nga , Zhang Xiu-Juan , Ling Xiang-Tian , Bui Christine Huyen-Trang , Wang Yu-Meng , Ip Patrick , Chu Wai-Kit , Chen Li-Jia , Tham Clement C. , Yam Jason C. , Pang Chi-Pui
Published: April 2022

The contributory roles of vitamin D in ocular and visual health have long been discussed, with numerous studies pointing to the adverse effects of vitamin D deficiency. In this paper, we provide a systematic review of recent findings on the association between vitamin D and different ocular diseases, including myopia, age-related macular degeneration (AMD), glaucoma, diabetic retinopathy (DR), dry eye syndrome (DES), thyroid eye disease (TED), uveitis, retinoblastoma (RB), cataract, and others, from epidemiological, clinical and basic studies, and briefly discuss vitamin D metabolism in the eye. We searched two research databases for articles examining the association between vitamin D deficiency and different ocular diseases. One hundred and sixty-two studies were found. There is evidence on the association between vitamin D and myopia, AMD, DR, and DES. Overall, 17 out of 27 studies reported an association between vitamin D and AMD, while 48 out of 54 studies reported that vitamin D was associated with DR, and 25 out of 27 studies reported an association between vitamin D and DES. However, the available evidence for the association with other ocular diseases, such as glaucoma, TED, and RB, remains limited.
Cardiovascular Characteristics of Zucker Fatty Diabetes Mellitus Rats, an Animal Model for Obesity and Type 2 Diabetes
Authors: Otani Kosuke , Funada Hiroshi , Teranishi Risa , Okada Muneyoshi , Yamawaki Hideyuki
Published: April 2022

Zucker fatty diabetes mellitus (ZFDM) rats harboring the missense mutation (fa) in a leptin receptor gene have been recently established as a novel animal model of obesity and type 2 diabetes (T2D). Here, we explored changes in cardiovascular dynamics including blood pressure and heart rate (HR) associated with the progression of obesity and T2D, as well as pathological changes in adipose tissue and kidney. There was no significant difference in systolic blood pressure (SBP) in ZFDM-Leprfa/fa (Homo) compared with ZFDM-Leprfa/+ (Hetero) rats, while HR and plasma adrenaline in Homo were significantly lower than Hetero. The mRNA expression of monocyte chemotactic protein-1 in perirenal white adipose tissue (WAT) from Homo was significantly higher than Hetero. Interscapular brown adipose tissue (BAT) in Homo was degenerated and whitened. The plasma blood urea nitrogen in Homo was significantly higher than Hetero. In summary, we demonstrated for the first time that HR and plasma adrenaline concentration but not SBP in Homo decrease with obesity and T2D. In addition, inflammation occurs in WAT from Homo, while whitening occurs in BAT. Further, renal function is impaired in Homo. In the future, ZFDM rats will be useful for investigating metabolic changes associated with the progression of obesity and T2D.
Heterozygous and Homozygous Variants in SORL1 Gene in Alzheimer’s Disease Patients: Clinical, Neuroimaging and Neuropathological Findings
Authors: Alvarez-Mora Maria Isabel , Blanco-Palmero Victor Antonio , Quesada-Espinosa Juan Francisco , Arteche-Lopez Ana Rosa , Llamas-Velasco Sara , Palma Milla Carmen , Lezana Rosales Jose Miguel , Gomez-Manjon Irene , Hernandez-Lain Aurelio , Jimenez Almonacid Justino , Gil-Fournier Belén , Ramiro-León Soraya , González-Sánchez Marta , Herrero-San Martín Alejandro Octavio , Pérez-Martínez David Andrés , Gómez-Tortosa Estrella , Carro Eva , Bartolomé Fernando , Gomez-Rodriguez Maria Jose , Sanchez-Calvin María Teresa , Villarejo-Galende Alberto , Moreno-Garcia Marta
Published: April 2022

In the last few years, the SORL1 gene has been strongly implicated in the development of Alzheimer’s disease (AD). We performed whole-exome sequencing on 37 patients with early-onset dementia or family history suggestive of autosomal dominant dementia. Data analysis was based on a custom panel that included 46 genes related to AD and dementia. SORL1 variants were present in a high proportion of patients with candidate variants (15%, 3/20). We expand the clinical manifestations associated with the SORL1 gene by reporting detailed clinical and neuroimaging findings of six unrelated patients with AD and SORL1 mutations. We also present for the first time a patient with the homozygous truncating variant c.364C>T (p.R122*) in SORL1, who also had severe cerebral amyloid angiopathy. Furthermore, we report neuropathological findings and immunochemistry assays from one patient with the splicing variant c.4519+5G>A in the SORL1 gene, in which AD was confirmed by neuropathological examination. Our results highlight the heterogeneity of clinical presentation and familial dementia background of SORL1-associated AD and suggest that SORL1 might be contributing to AD development as a risk factor gene rather than as a major autosomal dominant gene.
Are BPA Substitutes as Obesogenic as BPA?
Authors: Oliviero Fabiana , Marmugi Alice , Viguié Catherine , Gayrard Véronique , Picard-Hagen Nicole , Mselli-Lakhal Laila
Published: April 2022

Metabolic diseases, such as obesity, Type II diabetes and hepatic steatosis, are a significant public health concern affecting more than half a billion people worldwide. The prevalence of these diseases is constantly increasing in developed countries, affecting all age groups. The pathogenesis of metabolic diseases is complex and multifactorial. Inducer factors can either be genetic or linked to a sedentary lifestyle and/or consumption of high-fat and sugar diets. In 2002, a new concept of “environmental obesogens” emerged, suggesting that environmental chemicals could play an active role in the etiology of obesity. Bisphenol A (BPA), a xenoestrogen widely used in the plastic food packaging industry has been shown to affect many physiological functions and has been linked to reproductive, endocrine and metabolic disorders and cancer. Therefore, the widespread use of BPA during the last 30 years could have contributed to the increased incidence of metabolic diseases. BPA was banned in baby bottles in Canada in 2008 and in all food-oriented packaging in France from 1 January 2015. Since the BPA ban, substitutes with a similar structure and properties have been used by industrials even though their toxic potential is unknown. Bisphenol S has mainly replaced BPA in consumer products as reflected by the almost ubiquitous human exposure to this contaminant. This review focuses on the metabolic effects and targets of BPA and recent data, which suggest comparable effects of the structural analogs used as substitutes.
Implications of Sphingolipid Metabolites in Kidney Diseases
Authors: Mallela Shamroop kumar , Merscher Sandra , Fornoni Alessia
Published: April 2022

Sphingolipids, which act as a bioactive signaling molecules, are involved in several cellular processes such as cell survival, proliferation, migration and apoptosis. An imbalance in the levels of sphingolipids can be lethal to cells. Abnormalities in the levels of sphingolipids are associated with several human diseases including kidney diseases. Several studies demonstrate that sphingolipids play an important role in maintaining proper renal function. Sphingolipids can alter the glomerular filtration barrier by affecting the functioning of podocytes, which are key cellular components of the glomerular filtration barrier. This review summarizes the studies in our understanding of the regulation of sphingolipid signaling in kidney diseases, especially in glomerular and tubulointerstitial diseases, and the potential to target sphingolipid pathways in developing therapeutics for the treatment of renal diseases.
Effects of Host Plants on Bacterial Community Structure in Larvae Midgut of Spodoptera frugiperda
Authors: Chen Ya-Ping , Li Ya-Hong , Sun Zhong-Xiang , Du E-Wei , Lu Zhi-Hui , Li Hao , Gui Fu-Rong
Published: April 2022

The fall armyworm (FAW), Spodoptera frugiperda, is one of the most important invasive species and causes great damage to various host crops in China. In this study, the diversity and function of gut bacteria in the 5th instar larvae of FAW fed on maize, wheat, potato and tobacco leaves were analyzed through 16S rRNA sequencing. A total of 1324.25 ± 199.73, 1313.5 ± 74.87, 1873.00 ± 190.66 and 1435.25 ± 139.87 operational taxonomic units (OTUs) from the gut of FAW fed on these four different host plants were detected, respectively. Firmicutes, Proteobacteria and Bacteroidetes were the most abundant bacterial phyla. Beta diversity analysis showed that the gut bacterial community structure of larvae fed on different host plants was significantly differentiated. At the genus level, the abundance of Enterococcus in larvae fed on wheat was significantly lower than those fed on the other three host plants. Enterobacter and ZOR0006 were dominant in FAW fed on tobacco leaves, and in low abundance in larvae fed on wheat. Interestingly, when fed on Solanaceae (tobacco and potato) leaves which contained relative higher levels of toxic secondary metabolites than Gramineae (wheat and maize), the genera Enterococcus, Enterobacter and Acinetobacter were significantly enriched. The results indicated that gut bacteria were related to the detoxification and adaptation of toxic secondary metabolites of host plants in FAW. Further analysis showed that replication, repair and nucleotide metabolism functions were enriched in the gut bacteria of larvae fed on tobacco and potato. In conclusion, the gut bacterial diversity and community composition in FAW larvae fed on different host plants showed significant differences, and the insect is likely to regulate their gut bacteria for adaptation to different host plants.