bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of Chilled Dog Semen Extended With Sperm Activator
Authors: Martínez-Barbitta Marcelo , Rivera Salinas Claudio
Published: February 2022

Within modern biotechnology, different tools and methodologies have been developed to maximize canine semen conservation protocol to optimize reproductive results. In the last decades, the survival of chilled semen has been prolonged from 2 to 3 days with the first basic diluents, to 10–14 days with the modern extenders. However, their main limitation is that sperm quality decreases during cold storage. Sperm activators (SA) have been produced to provide the molecules necessary to maximize the sperm survival and quality with the aim to enhance fertility and prolificacy. In this study, the effect of commercial extender SA (Theriosolution® Canine AI extender -Chile-) was recorded by daily evaluation of chilled semen for 14 days. In this experiment, sperm-rich ejaculate fraction was collected from six adult healthy Neapolitan Mastiff dogs. The semen evaluation started immediately after collection (d0), and after that a next generation extender was added (d0) for every 24 h from d1 (with and without SA) to d14, to determine spermatozoa progressive motility, velocity of forward progression (VFP), morphology, and integrity of the spermatic membrane. The initial sperm concentration of extended semen was 417.3 ± 170.4 x 106/mL (mean ± SEM) with 85.89 ± 4.76% of MNS (morphologically normal sperm), 84.47 ± 5.22 % live sperm, and pH of 6.2 ± 2.8. The initial VFP was 3.83 ± 0.48, but after 1 min with SA, it rises to 4.45 ± 0.45 (P< 0.001). The sperm progressive motility parameter increases significantly (P< 0.05) in experimental trial, respect to control, starting to d2 at finish (except for d7). The VFP analysis significantly increases in experimental trial (P< 0.05) during most days of the study with the exclusion of d3 and d14. To evaluate the seminal characteristics over time, the experiment was divided into T1 (d0–d5), T2 (d6–d10), and T3 (d11–d14) (P< 0.001) in evaluation of morphology and membrane functionality. The MNS reached 70% at d10 and finally 65% at d14, being considered normal and possibly fertile. With Host-s, 65% of MNS were also achieved at d14. The presence of glucose and fructose in the diluents used for refrigeration can exert very important effects given the fact that metabolic routes have been found in both sugars, providing both different and complementing effects. It can be concluded that the use of SA prior to artificial insemination improves the quality of chilled semen significantly, although it does not reverse the effects of deterioration due to cellular metabolism over time.
Current Methods for Extraction and Concentration of Foodborne Bacteria with Glycan-Coated Magnetic Nanoparticles: A Review
Authors: Dester Emma , Alocilja Evangelyn
Published: February 2022

Rapid and accurate food pathogen detection is an essential step to preventing foodborne illnesses. Before detection, removal of bacteria from the food matrix and concentration to detectable levels are often essential steps. Although many reviews discuss rapid concentration methods for foodborne pathogens, the use of glycan-coated magnetic nanoparticles (MNPs) is often omitted. This review seeks to analyze the potential of this technique as a rapid and cost-effective solution for concentration of bacteria directly from foods. The primary focus is the mechanism of glycan-coated MNP binding, as well as its current applications in concentration of foodborne pathogens. First, a background on the synthesis, properties, and applications of MNPs is provided. Second, synthesis of glycan-coated particles and their theorized mechanism for bacterial adhesion is described. Existing research into extraction of bacteria directly from food matrices is also analyzed. Finally, glycan-coated MNPs are compared to the magnetic separation technique of immunomagnetic separation (IMS) in terms of cost, time, and other factors. At its current state, glycan-coated MNPs require more research to fully identify the mechanism, potential for optimization, and extraction capabilities directly in food matrices. However, current research indicates glycan-coated MNPs are an incredibly cost-effective method for rapid food pathogen extraction and concentration.
What Does PET Imaging Bring to Neuro-Oncology in 2022? A Review
Authors: Zhang-Yin Jules Tianyu , Girard Antoine , Bertaux Marc
Published: February 2022

PET imaging is being increasingly used to supplement MRI in the clinical management of brain tumors. The main radiotracers implemented in clinical practice include [18F]FDG, radiolabeled amino acids ([11C]MET, [18F]FDOPA, [18F]FET) and [68Ga]Ga-DOTA-SSTR, targeting glucose metabolism, L-amino-acid transport and somatostatin receptors expression, respectively. This review aims at addressing the current place and perspectives of brain PET imaging for patients who suffer from primary or secondary brain tumors, at diagnosis and during follow-up. A special focus is given to the following: radiolabeled amino acids PET imaging for tumor characterization and follow-up in gliomas; the role of amino acid PET and [18F]FDG PET for detecting brain metastases recurrence; [68Ga]Ga-DOTA-SSTR PET for guiding treatment in meningioma and particularly before targeted radiotherapy.
Development of Gene Expression-Based Random Forest Model for Predicting Neoadjuvant Chemotherapy Response in Triple-Negative Breast Cancer
Authors: Park Seongyong , Yi Gwansu
Published: February 2022

Neoadjuvant chemotherapy (NAC) response is an important indicator of patient survival in triple negative breast cancer (TNBC), but predicting chemosensitivity remains a challenge in clinical practice. We developed an 86-gene-based random forest (RF) classifier capable of predicting neoadjuvant chemotherapy response (pathological Complete Response (pCR) or Residual Disease (RD)) in TNBC patients. The performance of pCR classification of the proposed model was evaluated by Receiver Operating Characteristic (ROC) curve and Precision Recall (PR) curve. The AUROC and AUPRC of the proposed model on the test set were 0.891 and 0.829, respectively. At a predefined specificity (>90%), the proposed model shows a superior sensitivity compared to the best performing reported NAC response prediction model (69.2% vs. 36.9%). Moreover, the predicted pCR status by the model well explains the distance recurrence free survival (DRFS) of TNBC patients. In addition, the pCR probabilities of the proposed model using the expression profiles of the CCLE TNBC cell lines show a high Spearman rank correlation with cyclophosphamide sensitivity in the TNBC cell lines (SRCC =0.697, p-value =0.031). Associations between the 86 genes and DNA repair/cell cycle mechanisms were provided through function enrichment analysis. Our study suggests that the random forest-based prediction model provides a reliable prediction of the clinical response to neoadjuvant chemotherapy and may explain chemosensitivity in TNBC.
A Randomized Prospective Non-Inferiority Trial of Sentinel Lymph Node Biopsy in Early Breast Cancer: Blue Dye Compared with Indocyanine Green Fluorescence Tracer
Authors: Coibion Michel , Olivier Fabrice , Courtois Audrey , Maes Nathalie , Jossa Véronique , Jerusalem Guy
Published: February 2022

Background: Indocyanine green (ICG) is a promising tracer for sentinel lymph node biopsy in early breast cancer. This randomized study was conducted to evaluate sentinel lymph node biopsy with ICG compared with blue dye as a tracer in woman with early breast cancer without any sign of lymph node invasion. Methods: Between January 2019 and November 2020, 240 consecutive women with early breast cancer were enrolled and randomized to sentinel lymph node biopsy using ICG or blue dye. The primary endpoint was the sentinel lymph node detection rate in both arms. Results: ICG was used in 121 patients and detected sentinel lymph nodes in all patients (detection rate, 100%; 95% CI: 96.9–100.0) while blue dye was used in 119 patients and detected sentinel lymph nodes in 116 patients (detection rate: 97.5%, 95% CI: 92.9–99.1). This analysis indicated the non-inferiority of ICG vs. blue dye tracer (90%CI: −1.9–6.9; p = 0.0009). Conclusion: ICG represents a new promising tracer to detect sentinel lymph nodes in early breast cancer with a detection rate similar to other conventional tracers, and is associated with easy learning and low cost. Our result suggest that this technique is a good alternative to avoid radioactive isotope manipulation.
Primary Diffuse Large B-Cell Lymphoma of the Urinary Bladder: Update on a Rare Disease and Potential Diagnostic Pitfalls
Authors: Zanelli Magda , Sanguedolce Francesca , Zizzo Maurizio , Palicelli Andrea , Pellegrini David , Farinacci Sabrina , Soriano Alessandra , Froio Elisabetta , Cormio Luigi , Carrieri Giuseppe , Cavazza Alberto , Merli Francesco , Pileri Stefano A. , Ascani Stefano
Published: February 2022

Diffuse large B-cell lymphoma (DLBCL) represents the most frequent type of non-Hodgkin lymphoma. Globally, DLBCL is an aggressive disease, requiring an accurate diagnosis and prompt treatment. The diagnosis is often made on biopsy samples of a nodal mass, however, approximately 40% of DLBCL cases arise at extranodal sites. The most common extranodal site is the gastrointestinal tract, however any extranodal area may be primarily involved. Primary urinary bladder lymphoma represents only 0.2% of extranodal non-Hodgkin lymphomas, whereas secondary involvement of the urinary bladder by a systemic lymphoma is a more common event. Despite being rare, DLBCL is considered to represent the predominant primary urinary bladder lymphoma. The majority of cases reported in the bladder belong to the DLBCL, NOS group, and there are only rare cases of EBV-positive DLBCL, NOS. In this review, we summarize the current knowledge on DLBCL primarily occurring in the urinary bladder, with the aim of increasing clinician and pathologist awareness on this aggressive lymphoma rarely arising in the urinary bladder. Additionally, we focus on those entities which should be taken into consideration in the differential diagnosis, highlighting potential diagnostic pitfalls.
Influence of Tumor Site on Survival in Young Patients with Head and Neck Squamous Cell Carcinoma
Authors: Steffen Claudius , Piwonski Iris , Heiland Max , Stromberger Carmen , Kofla Grzegorz , Doll Christian , Coordes Annekatrin , Beck-Broichsitter Benedicta
Published: February 2022

The number of patients under the age of 45 diagnosed with head and neck squamous cell carcinomas (HNSCC) is increasing, probably due to the incidence of oropharyngeal cancers. Comparisons of HNSCC in young and old patients regarding tumor site and survival in sample sizes of relevance are rarely published. The aim of the study was to analyze the differences in survival between age groups dependent on tumor site and the influence of oropharyngeal cancers on the rising rates of HNSCC in the young. The records of 4466 patients diagnosed with HNSCC were reviewed retrospectively. Patients younger than 45 years were divided further into four subgroups for specific age differences in the young. The influences of patient and clinicopathological characteristics on survival were assessed using Kaplan–Meier analyses. Among the patient cohort, 4.8% were younger than 45 years. Overall survival (OS) in these patients was better, with a 5-year OS of 66.1% (vs. 46.4%), while relapse-free survival (RFS) was better in the older patient population, with a 5-year RFS of 74.9% (vs. 68.1%). Decreased RFS in the young was found for advanced tumor stages and tumor sited at the larynx. Hypopharynx and advanced stages were independent risk factors for OS under 45 years. Overall, 44.4% of all HNSCC in patients under 30 years were nasopharyngeal cancers, and incidence decreased with age. The incidence of oropharyngeal cancers increased significantly with age. Better OS in the young may be explained by lower tumor and disease stages, whereas oropharyngeal tumors and HPV were not found to cause rising rates of HNSCC. Laryngeal malignancies in young patients might be related to an increased malignant potential and should, consequently, be treated as such.
Closing the Gaps to Timely Patient Access: Perspectives on Conditional Funding Models
Authors: Glennie Judith , Villalba Eva , Wheatley-Price Paul
Published: February 2022

The Canadian system for approval of new cancer drugs is complex with multiple steps. Health Canada grants a license for a drug to be marketed and prescribed. The Canadian Agency for Drugs and Technologies in Health (CADTH) and Institut national d’excellence en santé et services sociaux (INESSS) make recommendations by way of health technology assessments (HTA). If positive, the latter then lead to confidential price negotiations at the pan-Canadian pharmaceutical alliance (pCPA), after which individual provinces and territories make a listing decision. Delays can occur at each stage, but post-HTA delays can be lengthy and unpredictable, denying or impeding access to an effective drug with the potential for devastating clinical outcomes. Conditional funding models have been adopted in a number of European countries with the goal of providing timely access to new medications in areas of unmet need, in advance of further steps in the reimbursement process. This manuscript discusses different stakeholder perspectives on conditional funding agreements—including a recent successful example of such a process in the UK—based on a panel discussion at the 2021 Canadian Association of Population Therapeutics (CAPT) Conference.
Risk Association of TOX3 and MMP7 Gene Polymorphisms with Sporadic Breast Cancer in Mexican Women
Authors: Solis-Coronado Orlando , Villarreal-Vela Mónica Patricia , Rodríguez-Gutiérrez Hazyadee Frecia , González-Guerrero Juan Francisco , Cerda-Flores Ricardo M. , Alcorta-Núñez Fernando , Camarillo-Cárdenas Karen Paola , Pérez-Ibave Diana Cristina , Vidal-Gutiérrez Oscar , Ramírez-Correa Genaro A. , Garza-Rodríguez María Lourdes
Published: February 2022

Breast cancer (BC) has one of the highest incidences and mortality worldwide. Single nucleotide polymorphisms (SNPs) in TOX3 rs3803662 and MMP7 rs1943779 have been associated with susceptibility to BC. In this case-control study, we evaluated the association of rs3803662 (TOX3)/rs1943779 (MMP7) SNPs with clinical features, immunohistochemical reactivity, and risk association with BC in women from northeastern Mexico. We compared 212 BC cases and 212 controls. DNA was isolated from peripheral blood to perform the polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. We calculated genotype frequencies, odds ratios, and 95% confidence intervals. We found that CT (Cytocine–Thymine) and TT (Thymine –Thymine) genotypes, and T alleles of TOX3 rs3803662, were associated with BC risk (p = 0.034, p = 0.011, respectively). SNP TOX3 rs3803662 was associated with positive progesterone receptors (PR) and triple-negative BC (TNBC) but not with estrogen receptor (ER) or HER2 reactivity. CT and TT genotypes (p = 0.006) and T alleles (p = 0.002) of SNP MMP7 rs1943779 were associated with risk of BC. We found that T alleles of TOX3 rs3803662 and MMP7 rs1943779 SNPs are associated with BC risk. These findings contribute to personalized medicine in Mexican women.
Heterogeneous Criticality in High Frequency Finance: A Phase Transition in Flash Crashes
Authors: Turiel Jeremy D. , Aste Tomaso
Published: February 2022

Flash crashes in financial markets have become increasingly important, attracting attention from financial regulators, market makers as well as from the media and the broader audience. Systemic risk and the propagation of shocks in financial markets is also a topic of great relevance that has attracted increasing attention in recent years. In the present work, we bridge the gap between these two topics with an in-depth investigation of the systemic risk structure of co-crashes in high frequency trading. We find that large co-crashes are systemic in their nature and differ from small ones. We demonstrate that there is a phase transition between co-crashes of small and large sizes, where the former involves mostly illiquid stocks, while large and liquid stocks are the most represented and central in the latter. This suggests that systemic effects and shock propagation might be triggered by simultaneous withdrawals or movement of liquidity by HFTs, arbitrageurs and market makers with cross-asset exposures.
Reduced System Complexity of Heart Rate Dynamics in Patients with Hyperthyroidism: A Multiscale Entropy Analysis
Authors: Chen Jin-Long , Shen Hsuan-Shu , Peng Shih-Yi , Wang Hung-Ming
Published: February 2022

Studying heart rate dynamics would help understand the effects caused by a hyperkinetic heart in patients with hyperthyroidism. By using a multiscale entropy (MSE) analysis of heart rate dynamics derived from one-channel electrocardiogram recording, we aimed to compare the system complexity of heart rate dynamics between hyperthyroid patients and control subjects. A decreased MSE complexity index (CI) computed from MSE analysis reflects reduced system complexity. Compared with the control subjects (n = 37), the hyperthyroid patients (n = 37) revealed a significant decrease (p < 0.001) in MSE CI (hyperthyroid patients 10.21 ± 0.37 versus control subjects 14.08 ± 0.21), sample entropy for each scale factor (from 1 to 9), and high frequency power (HF) as well as a significant increase (p < 0.001) in low frequency power (LF) in normalized units (LF%) and ratio of LF to HF (LF/HF). In conclusion, besides cardiac autonomic dysfunction, the system complexity of heart rate dynamics is reduced in hyperthyroidism. This finding implies that the adaptability of the heart rate regulating system is impaired in hyperthyroid patients. Additionally, it might explain the exercise intolerance experienced by hyperthyroid patients. In addition, hyperthyroid patients and control subjects could be distinguished by the MSE CI computed from MSE analysis of heart rate dynamics.
A Review of Security Evaluation of Practical Quantum Key Distribution System
Authors: Sun Shihai , Huang Anqi
Published: February 2022

Although the unconditional security of quantum key distribution (QKD) has been widely studied, the imperfections of the practical devices leave potential loopholes for Eve to spy the final key. Thus, how to evaluate the security of QKD with realistic devices is always an interesting and opening question. In this paper, we briefly review the development of quantum hacking and security evaluation technology for a practical decoy state BB84 QKD system. The security requirement and parameters in each module (source, encoder, decoder and detector) are discussed, and the relationship between quantum hacking and security parameter are also shown.
Plasma-like Description for Elementary and Composite Quantum Particles
Authors: Akhmeteli Andrey
Published: February 2022

Schrödinger noticed in 1952 that a scalar complex wave function can be made real by a gauge transformation. The author showed recently that one real function is also enough to describe matter in the Dirac equation in an arbitrary electromagnetic or Yang–Mills field. This suggests some “symmetry” between positive and negative frequencies and, therefore, particles and antiparticles, so the author previously considered a description of one-particle wave functions as plasma-like collections of a large number of particles and antiparticles. The description has some similarities with Bohmian mechanics. This work offers a criterion for approximation of continuous charge density distributions by discrete ones with quantized charge based on the equality of partial Fourier sums, and an example of such approximation is computed using the homotopy continuation method. An example mathematical model of the description is proposed. The description is also extended to composite particles, such as nucleons or large molecules, regarded as collections including a composite particle and a large number of pairs of elementary particles and antiparticles. While it is not clear if this is a correct description of the reality, it can become a basis of an interesting model or useful picture of quantum mechanics.
Experimental Study on Manned/Unmanned Thermal Environment in Radar Electronic Shelter Based on Different Air Supply Conditions
Authors: Qu Jue , Guo Hao , Xue Hongjun , Dang Sina , Chen Yingchun
Published: February 2022

Studies on the thermal environment of the electronic radar shelter have been mainly focused on the simulation of the unmanned thermal environment, and there have been few studies on experiments in the thermal environment. Additionally, a comparative study of the experimental results from manned and unmanned shelters has been missing. In this paper, we experimented in thermal environments of manned/unmanned shelter under different air supply conditions. The experiment was divided into cooled, ventilated, and heated trials analyzing three aspects: (1) The average temperature distributions of walls, air inlet points, air outlet points, and surfaces were measured over time under different conditions in an unmanned shelter. The temperature distribution curve was fitted into the function. (2) Based on different working conditions, the temperature distribution experiments were carried out in three different areas for subjects wearing short or long clothing respectively. (3) The wind speed was measured at each measuring point in the air supply pipeline under different working conditions. The wind speed distribution was detected on the setting surfaces. The experimental results show that: (1) The air does not gradually tend to steady state with the time, and under different conditions, the air temperature obviously differs. (2) The clothing selection, air supply conditions, and locations of measuring points have significant influences on human body temperature distribution and left–right difference. (3) The mixing of the thermal plume caused by the vertical temperature difference of the human body and the jet generated by the mechanical air supply will reduce the wind speed of the airflow in the cabin, the adsorption of the jet to the bulkhead, and the stability of the airflow. The experimental data can provide the initial and boundary conditions for the simulation of the shelter. The results can provide a reference for the study of fluid control methods, the setting of thermal boundary conditions, and the simulation of the influence of thermal plumes on the airflow distribution. The experimental study in this paper has filled in the blanks regarding experimental study in electronic radar shelters. It has important research value and practical significance.
Building-Integrated Photovoltaic Modules Using Additive-Manufactured Optical Pattern
Authors: Kim Young-Su , Kim A-Rong , Tark Sung-Ju
Published: February 2022

This paper suggests a novel way to manufacture power-efficient building-integrated photovoltaic (BIPV) modules that are aesthetically acceptable for use in zero-energy buildings (ZEBs). An optical pattern is formed using additive manufacturing (AM) to maximize the number of sunrays that reach the solar cells and to hide cells beneath the pattern. The optical pattern was optimized by simulation, then selected PV modules were fabricated to ensure that they met the optimal optical pattern conditions. Increase in pattern angle and lens space yielded increase in the output power of the PV module, but reduced the aesthetic functionality. This color BIPV technology is expected to help expand the BIPV market and reduce carbon for “net zero” objectives.
Assessing the Energy Consumption and Driving Range of the QUIET Project Demonstrator Vehicle
Authors: Patrone Gian Luca , Paffumi Elena , Otura Marcos , Centurelli Mario , Ferrarese Christian , Jahn Steffen , Brenner Andreas , Thieringer Bernd , Braun Daniel , Hoffmann Thomas
Published: February 2022

This article summarises the experimental testing campaign performed at the Joint Research Centre (JRC) on the demonstrator battery electric vehicle (BEV) of the European Union Horizon 2020 research project QUIET. The project, launched in October 2017, aimed at developing an improved and energy-efficient electric vehicle with increased driving range under real-world driving conditions, focusing on three areas: improved energy management, lightweight materials with enhanced thermal insulation properties, and improved safety and comfort. A heating, venting, and air conditioning (HVAC) system based on the refrigerant R290 (propane), a phase change material (PCM) thermal storage system, infrared heating panels in the near field of the passengers, lightweight materials for seat internal structures, and composite vehicle doors with a novel atomically precise manufacturing (APM) aluminium foam are all the breakthrough technologies installed on the QUIET demonstrator vehicle. All these innovative technologies allow the energetic request for cooling and heating the cabin of the demonstrator vehicle under different driving conditions and the weight of the vehicle components (e.g., doors, windshields, seats, heating, and air conditioning) to be reduced by about 28%, leading to an approximately 26% driving range increase under both hot (40 °C) and cold (−10 °C) weather conditions.
A Review on the Unit Commitment Problem: Approaches, Techniques, and Resolution Methods
Authors: Montero Luis , Bello Antonio , Reneses Javier
Published: February 2022

Optimizing the schedule of thermal generators is probably the most important task when the operation of power systems is managed. This issue is known as the unit commitment problem in operational research. It has been profoundly studied in the literature, where several techniques have been proposed to address a computationally tractable solution. In turn, the ongoing changes of paradigms in energy markets focus the attention on the unit commitment problem as a powerful tool to handle new trends, such as the high renewable energy sources penetration or widespread use of non-conventional energy-storage technologies. A review on the unit commitment problem is propo- sed in this paper. The easy understanding of the diverse techniques applied in the literature for new researchers is the main goal of this state-of-art as well as identifying the research gaps that could be susceptible to further developments. Moreover, an overview of the evolution of the Mixed Integer Linear Programming formulation regarding the improvements of commercial solvers is presented, according to its prevailing hegemony when the unit commitment problem is addressed. Finally, an accurate analysis of modeling detail, power system representation, and computational performance of the case studies is presented. This characterization entails a significant development against the conventional reviews, which only offer a broad vision of the modeling scope of their citations at most.
Flashover Voltage Prediction Models under Agricultural and Biological Contaminant Conditions on Insulators
Authors: Khatoon Shabana , Khan Asfar Ali , Tariq Mohd , Alamri Basem , Mihet-Popa Lucian
Published: February 2022

The flashover performance of contaminated insulators highly depends on the type of pollutant and its present concentration. In this paper, important agricultural salts (NaCl, K2SO4, NaHCO3, CaSO4, KHCO3, MgSO4, NH4), 2Fe(SO4)2, and 6H2O (ferrous ammonium sulphate, dust, and urea) at different concentrations, and biological contaminants, such as algae and fungi, were taken as pollutants, and the AC flashover behavior of a porcelain-cap-and-pin-type insulator polluted with these two different pollutants was investigated. The experiment was carried out by a semi-natural method, wherein the insulator was first polluted artificially; thereafter, natural fog was applied to measure the wet flashover voltage. Test results indicated that the flashover voltages were affected by both soluble salts and non-soluble components deposited on the insulator surface. In the case of the thickly contaminated layers, non-soluble deposits greatly reduced the flashover voltage. Moreover, by using regression analysis, four empirical models based on different variables were developed. The empirical models developed in the present work represented a good degree of relation in predicting the flashover voltage of naturally contaminated insulators.
The Impact of Social Conformity on Adopting Decision of Shared Electric Vehicles: A Choice Experiment Analysis in China
Authors: Li Wenbo , Wang Mengzhe , Yu Miao , Zheng Xiao
Published: February 2022

Social conformity, a psychological phenomenon commonly shared by most individuals, has long been ignored by studies focusing on influencing preferences for shared electric vehicles (SEVs). To fill this gap, this paper divides social conformity into informational conformity and normative conformity, and analyzes their effects on individuals’ choice of SEVs. Respondents were selected randomly in Jiangsu Province, and the data were collected by the choice experiment method. The data were further analyzed by logit models. Results show that social conformity has a significant positive impact on individuals’ choice of SEVs, and informational conformity has a much more profound impact than normative conformity. The driving cost and the convenience of picking up and returning a vehicle also influence consumers’ preferences. In addition, social conformity cannot totally dispel the negative impact of poor experience. Finally, some targeted policy recommendations are proposed.
Social Health among German Nursing Home Residents with Dementia during the COVID-19 Pandemic, and the Role of Technology to Promote Social Participation
Authors: Hoel Viktoria , Seibert Kathrin , Domhoff Dominik , Preuß Benedikt , Heinze Franziska , Rothgang Heinz , Wolf-Ostermann Karin
Published: February 2022

The COVID-19 pandemic severely impacted the social health of nursing home residents with dementia due to social isolation. Consequently, the frequency of Behavioral and Psychological Symptoms in Dementia (BPSD) might increase. Technological solutions might help safeguard the social health of nursing home residents with dementia. This study investigates the impacts of the COVID-19 pandemic on clinical outcomes and the availability of social activities and technology to promote social participation in nursing home residents with dementia. The study analyzed cross-sectional data from a follow-up questionnaire nested in a larger national survey of care facilities in Germany. A mixed-methods approach integrated statistical analyses of closed-ended responses and thematic analysis of free-text responses. A total of 417 valid individual responses were received, showing an overall increase in observed BPSD—with anxiety and depression most frequently occurring. Many nursing homes canceled all social activities for residents with dementia, though a few had established procedures to facilitate social participation using technology. Requirements to promote social participation in this population using technology were identified at the micro-, meso-, and macro levels. Technology requirements permeated all three levels. During and beyond the COVID-19 pandemic, technology-driven solutions to promote social health among nursing home residents with dementia should be integrated into caregiving procedures.
Quantitative Microbial Risk Assessment Applied to Legionella Contamination on Long-Distance Public Transport
Authors: Federigi Ileana , De Giglio Osvalda , Diella Giusy , Triggiano Francesco , Apollonio Francesca , D’Ambrosio Marilena , Cioni Lorenzo , Verani Marco , Montagna Maria Teresa , Carducci Annalaura
Published: February 2022

The quantitative microbial risk assessment (QMRA) framework is used for assessing health risk coming from pathogens in the environment. In this paper, we used QMRA to evaluate the infection risk of L. pneumophila attributable to sink usage in a toilet cabin on Italian long-distance public transportation (LDT). LDT has water distribution systems with risk points for Legionella proliferation, as well as premise plumbing for drinking water, but they are not considered for risk assessment. Monitoring data revealed that approximately 55% of water samples (217/398) were positive for L. pneumophila, and the most frequently isolated was L. pneumophila sg1 (64%, 139/217); therefore, such data were fitted to the best probability distribution function to be used as a stochastic variable in the QMRA model. Then, a sink-specific aerosolization ratio was applied to calculate the inhaled dose, also considering inhalation rate and exposure time, which were used as stochastic parameters based on literature data. At L. pneumophila sg1 concentration ≤100 CFU/L, health risk was approximately 1 infection per 1 million exposures, with an increase of up to 5 infections per 10,000 exposures when the concentrations were ≥10,000 CFU/L. Our QMRA results showed a low Legionella infection risk from faucets on LDT; however, it deserves consideration since LDT can be used by people highly susceptible for the development of a severe form of the disease, owing to their immunological status or other predisposing factors. Further investigations could also evaluate Legionella-laden aerosols from toilet flushing.
Interventions to Improve Child Physical Activity in the Early Childhood Education and Care Setting: An Umbrella Review
Authors: Lum Melanie , Wolfenden Luke , Jones Jannah , Grady Alice , Christian Hayley , Reilly Kathryn , Yoong Sze Lin
Published: February 2022

Early childhood education and care (ECEC) services are a key setting to support improvements in the physical activity of young children. This umbrella review gathered and synthesised systematic review evidence of the effectiveness of interventions in the ECEC setting on the physical activity levels of children aged 0–6. We also mapped the current evidence to the existing ECEC sector-specific physical activity practice recommendations. Five electronic databases were searched to identify systematic reviews that evaluated the impact of any ECEC-based interventions on the physical activity levels (e.g., moderate-to-vigorous physical activity, total physical activity) of children aged 0–6. One reviewer extracted data on intervention effectiveness and quality of the reviews, checked by a second reviewer. Ten reviews were included. Overall, the majority of the reviews found interventions delivered in ECEC improved child physical activity. Across reviews, the impact of six intervention strategies were identified, mapped to four (of eight) broad recommendations (i.e., providing opportunity, offering educator training, educators promoting the benefits of physical activity, creating a physical activity-promoting environment). The impact of the majority of recommendations, however, did not have systematic review evidence. Further investigation of the effectiveness of ECEC-based physical activity strategies is required to demonstrate support for the existing recommended practices.
Do Remittances Enhance Elderly Adults’ Healthy Social and Physical Functioning? A Cross-Sectional Study in Nigeria
Authors: Ojijieme Nnaelue Godfrey , Qi Xinzhu , Chui Chin-Man
Published: February 2022

Existing research demonstrates that the effect of remittances on different health outcomes of elderly adults in low-income countries with inadequate social security is inconclusive. The present study set out to fill this gap by examining the effects of receiving remittances on the healthy social and physical functioning of Nigeria’s elderly adults. We also investigate the nonlinear association between remittances and social and physical functioning to identify the minimum amount required to engender healthy social and physical functioning in Nigerian elderly adults. This study utilized data from the 2018/2019 Nigerian Living Standard Survey (NLSS), which included 55,350 young people aged 12–44 (control group) and 18,937 elderly adults aged 45 and above (treatment group). We addressed our objectives using logistic regression-adjusted predicted probabilities and predictive margins. The results reveal that remittance recipients have higher healthy social functioning probabilities than non-recipients. We also found that the influence that remittances have on social functioning depends on the amount of the remittances received. Quantitatively, receiving more than NGN 1,200,000 in remittances ensures increased social functioning probabilities. Given the disparity between the average remittance amount of NGN 54,306.92 received by elderly adults and the NGN 1,200,000 threshold associated with healthy social functioning, bridging this gap is paramount for promoting social functioning among Nigerian elderly adults. We also discussed policy implications for fostering the healthy aging of the population in the interim.
Development and Evaluation of the Course on Global Health Nursing for Indian Nursing Students
Authors: Rajaguru Vasuki , Oh Jina , Im Mihae
Published: February 2022

The purpose of this study was to develop and evaluate the effectiveness of the course on Global Health Nursing for Indian nursing students, intended to introduce the course as a selective course in the nursing curriculum. Methods: A quasi-experimental nonequivalent control group pre- and post-test design was carried out. The study participants were fifty final grade nursing students, considered as an experimental (n = 25) and control group (n = 25). The participants recruited by purposive sampling were fifty 4th grade nursing students (experimental 25, control 25) at St. X College of Nursing, India. The course on Global Health Nursing was developed by using the ADDIE model, and the duration of the course was about 16 h over three weeks. The course was implemented based on Gagné’s instructional method. Data were collected by self-perceived scales of Global Health Nursing before and after the course, the participants’ opinions, and feedback providing comments about the course. Results: The study results showed improvement in knowledge (F = 8.48; p < 0.001), skills (F = 96.14; p < 0.001), and performance on Global Health Nursing (F = 5.50; p < 0.001) and was statistically significant. Moreover, the participants described that they were satisfied with the quality of teaching–learning and achieved the learning goals. Conclusion: The outcome of this study could be extended to the existing nursing curriculum and would be modified to formulate a standard module in the curriculum of the Indian nursing system. The study offers implications for different fields of nursing, including nursing education, research, and practice in India.
The Effect of the “Colorful Eating Is Healthy Eating” Long-Term Nutrition Education Program for 3- to 6-Year-Olds on Eating Habits in the Family and Parental Nutrition Knowledge
Authors: Kostecka Malgorzata
Published: February 2022

Background: Effective strategies for improving eating habits and dietary intake in preschoolers are essential for reducing the risk of chronic non-infectious diseases in later life. The aim of this study was to evaluate the effect of long-term nutrition education for 3- to 6-year-olds on parental nutrition knowledge. Methods: The study was conducted as part of the “Colorful Eating is Healthy Eating” nutrition education program that has been implemented in kindergartens in Lublin since 2016. A total of 11 kindergartens were involved in this stage of the program, and 733 parents consented to participate in the project. The study was divided into three stages. In the first stage all parents completed a questionnaire containing 54 items. In the next stage, 211 children from four randomly selected kindergartens participated in the “Colorful Eating Is Healthy Eating” educational program that lasted 7 months. In the third stage of the study, the parents of children who had completed the 7-month educational program and the parents of control group children once again completed the questionnaire. Results: A positive outcome of the educational program was that it contributed to a decrease in the consumption of sweetened hot beverages (p = 0.005) and an increase in water intake (p = 0.001). The nutrition education program was also successful in reducing the consumption of sweets. Children’s education improved the parents’ knowledge about dietary sources of fiber and the recommended fiber intake, and it contributed to the awareness that breakfast is the most important meal of the day. The program did not enhance the parents’ knowledge about snacking between meals or the role of sweetened beverages in dental caries, overweight and obesity. Conclusions: Long-term multi-stage nutrition education for children aged 3 to 6 years can be helpful in shaping families’ eating habits and improving parental nutrition knowledge. However, the program was less effective in eliminating the respondents’ preference for sweet-tasting foods.
To Change or Not to Change: A Study of Workplace Change during the COVID-19 Pandemic
Authors: Da Shu , Fladmark Silje Fossum , Wara Irina , Christensen Marit , Innstrand Siw Tone
Published: February 2022

After the outbreak of the COVID-19 pandemic, many employees were suddenly required to work more from home. Previous literature on working from home may not be applicable to this mandatory and overall change. In this study, we drew on the Job Demands–Resources (JD-R) model to explore the relationships between job demands (workload and work–home conflict) as well as resources (support from leaders, coworkers, and the family) and wellbeing (burnout and work engagement) in employees who still went to the workplace (no-change group) and employees who transitioned into working from home (change group) during the COVID-19 pandemic. Data were analyzed with multivariate structural equation modeling. The results indicate that work–home conflict was detrimental for employee wellbeing in both groups. Interestingly, the workload seems to contribute to work engagement for employees who worked from home. Regarding the resources, the three different sources of social support, leaders, coworkers, and family, were all related to employee wellbeing, but in different ways. It seemed that family support was most important for employees’ wellbeing in the change group. This study presents implications for the wellbeing of employees in both the change and no-change group during the COVID-19 pandemic, emphasizing the importance of family-friendly policies.
The Trend of Authentic Leadership Skills in Nursing Education: The Key Role of Perfectionism and Self-Efficacy
Authors: Jaworski Mariusz , Panczyk Mariusz , Leńczuk-Gruba Anna , Nowacka Agnieszka , Gotlib Joanna
Published: February 2022

(1) Background: Shaping leadership skills is a complex process, which may be modified by psychological factors such as self-efficacy and perfectionism. The aim of the study was to determine whether perfectionism can be a mediator between self-efficacy, and authentic leadership skills in nursing students; (2) Methods: The cross-sectional study included 615 Polish nursing students (women = 96.3%) was carried out at Medical University of Warsaw in 2019. The following research tools were used: Authentic Leadership Questionnaire, Almost Perfect Scale-Revised (APS-R), and General Self-Efficacy Scale (GSES); (3) Results: The level of perfectionism is a significant mediator of relations between self-efficacy as measured by the GSES and the level of authentic leadership (Sobel test: t = 6.958; p < 0.000). The relation, without a mediating factor, is positive, and the standardized beta coefficient for the feeling of self-efficacy totals beta = 0.470 (p < 0.000), while in the presence of a mediator the strength of the correlation is smaller and amounts to beta = 0.366 (p < 0.000); (4) Conclusions: Personality factors such as self-efficacy and perfectionism play an important role in shaping AL skills of nursing students. Therefore, academic teachers should pay special attention to strengthening students’ self-efficacy and adaptive perfectionism. In this context, adequate feedback and reflection may be important.
Identification of the Regulatory Genes of UV-B-Induced Anthocyanin Biosynthesis in Pepper Fruit
Authors: Wang Yihao , Liu Sujun , Wang Haoran , Zhang Yingxue , Li Wenjie , Liu Jinkui , Cheng Qing , Sun Liang , Shen Huolin
Published: February 2022

Fruit peels of certain pepper (Capsicum annum L.) varieties accumulate a large amount of anthocyanins and exhibit purple color under medium-wave ultraviolet (UV-B) conditions, which severely impacts the commodity value of peppers. However, the regulatory mechanism of the above process has not been well studied so far. To explore which key genes are involved in this regulatory mechanism, pepper variety 19Q6100, the fruit peels of which turn purple under UV-B conditions, was investigated in this study. Transcription factors with expression levels significantly impacted by UV-B were identified by RNA-seq. Those genes may be involved in the regulation of UV-B-induced anthocyanin biosynthesis. Yeast one-hybrid results revealed that seven transcription factors, CabHLH143, CaMYB113, CabHLH137, CaMYBG, CaWRKY41, CaWRKY44 and CaWRKY53 directly bound to the putative promotor regions of the structural genes in the anthocyanin biosynthesis pathway. CaMYB113 was found to interact with CabHLH143 and CaHY5 by yeast two-hybrid assay, and those three genes may participate collaboratively in UV-B-induced anthocyanin biosynthesis in pepper fruit. Virus-induced gene silencing (VIGS) indicated that fruit peels of CaMYB113-silenced plants were unable to turn purple under UV-B conditions. These findings could deepen our understanding of UV-B-induced anthocyanin biosynthesis in pepper.
Effect of Curcumin in Experimental Pulmonary Tuberculosis: Antimycobacterial Activity in the Lungs and Anti-Inflammatory Effect in the Brain
Authors: Lara-Espinosa Jacqueline V. , Arce-Aceves María Fernanda , López-Torres Manuel O. , Lozano-Ordaz Vasti , Mata-Espinosa Dulce , Barrios-Payán Jorge , Silva-Islas Carlos Alfredo , Maldonado Perla D. , Marquina-Castillo Brenda , Hernández-Pando Rogelio
Published: February 2022

Tuberculosis (TB) is one of the ten leading causes of death worldwide. Patients with TB have been observed to suffer from depression and anxiety linked to social variables. Previous experiments found that the substantial pulmonary inflammation associated with TB causes neuroinflammation, neuronal death, and behavioral impairments in the absence of brain infection. Curcumin (CUR) is a natural product with antioxidant, anti-inflammatory and antibacterial activities. In this work, we evaluated the CUR effect on the growth control of mycobacteria in the lungs and the anti-inflammatory effect in the brain using a model of progressive pulmonary TB in BALB/c mice infected with drug-sensitive mycobacteria (strain H37Rv). The results have shown that CUR decreased lung bacilli load and pneumonia of infected animals. Finally, CUR significantly decreased neuroinflammation (expression of TNFα, IFNγ and IL12) and slightly increased the levels of nuclear factor erythroid 2-related to factor 2 (Nrf2) and the brain-derived neurotrophic factor (BDNF) levels, improving behavioral status. These results suggest that CUR has a bactericidal effect and can control pulmonary mycobacterial infection and reduce neuroinflammation. It seems that CUR has a promising potential as adjuvant therapy in TB treatment.