bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects on Greenhouse Gas (CH4, CO2, N2O) Emissions of Conversion from Over-Mature Forest to Secondary Forest and Korean Pine Plantation in Northeast China
Authors: Wu Bin , Mu Changcheng
Published: September 2019

This study aimed to evaluate the seasonal variations of Greenhouse Gas fluxes (CH4, CO2, and N2O), Greenhouse Gas (GHG) emissions, and Global Warming Potential (GWP) over the extent of the regions and understand the controlling factors. CH4, CO2, and N2O fluxes were measured along with their environmental variables from the over-mature forest, Korean pine plantation, and five 60-year-old natural secondary forests in mountainous regions in Northeast China from May 2015 to April 2016. The results revealed that secondary forests, except for Betula platyphylla forest, significantly increased CH4 absorption by 19.6% to 51.0% and 32.6% to 67.0% compared with over-mature forest (OMF) and Korean pine plantation (KPP). Five secondary forests significantly increased CO2 flux by 32.9% to 78.6% and 14.1% to 53.4% compared with OMF and KPP, respectively. According to the annual statistics, the N2O fluxes had significant differences among seven forest types and decreased in the following order: mixed deciduous forest (MDF) > OMF > KPP > Populous davidiana forest (PDF) > hardwood forest (HWF) > Mongolian oak forest (MOF) > Betula platyphylla forest (BPF). The CH4 absorption and CO2 emission peaks occurred in summer, while the peak N2O fluxes occurred in spring. Stepwise multiple linear regression showed that CH4 and CO2 fluxes from soils were strongly influenced by air and soil temperature, soil volumetric water content (SVWC), nitrate nitrogen (NO3−-N), ammonium nitrogen (NH4+-N), and soil organic carbon (SOC) across the whole year. Air temperature, SVWC, pH, NO3−-N, and NH4+-N were the dominant factors controlling N2O fluxes from OMF and five secondary forests (except for BPF). No significant relationships were observed between these environmental factors and N2O fluxes from KPP and BPF. Additionally, the total cumulative CH4, CO2, and N2O fluxes were –13.37 t CH4 year−1, 41,608.96 t CO2 year−1, and 3.24 t N2O year−1, and the total cumulative GWP were 42,151.87 t CO2 eq year−1 through the whole year in seven forest types at the Maoershan Ecosystem Research Station in Northeast China. For the annual GWP per hectare, secondary forests and KPP averaged a higher GWP by 33.7%–80.1% and 17.9% compared with OMF. This indicates that the effects of early human activities have not been completely eliminated in the middle stage of KPP and secondary forests.
Effects of Bird Traits on Seed Dispersal of Endangered Taxus chinensis (Pilger) Rehd. with Ex-Situ and In-Situ Conservation
Authors: Li Ning , Wang Zheng , Li Xin-Hai , Yi Xian-Feng , Yan Chuan , Lu Chang-Hu , Chen Si-Chong
Published: September 2019

Biodiversity is rapidly decreasing worldwide. Its great importance has been attached to conservation through in-situ and ex-situ management. Animal-mediated seed dispersal is an important ecological process, linking the threatened plants and animal partners in ex-situ habitats, and in turn affecting tree conservation. However, how bird traits affect seed dispersal within in-situ and ex-situ conservation still remains unclear. Here, we aim to answer this question. We tested whether bird traits affect seed deposition and seedling recruitment. Our results showed that 19 bird species foraged and removed Taxus chinensis (Pilger) Rehd. seeds across botanical gardens (ex-situ) and natural reserves (in-situ). The seed dispersal pattern of T. chinensis varied in the stages of seed removal and seed deposition, but showed no significant difference in the seedling recruitment stage. This showed that bird morphological and behavioral traits affected seed dispersal through the different contributions of varying bird species. Large birds and their high visitation frequency played a central role in seed removal patterns. The frequency of post-foraging habitat use was the most important factor determining the role of birds in seed deposition and the following seedling recruitment. Urocissa erythrorhyncha and Chloropsis hardwickii played the role of keystone species in seed deposition and seedling recruitment, respectively. Our results highlight the importance of bird traits in facilitating the seed dispersal of trees within in-situ and ex-situ conservation, which should be considered in future forest conservation and management.
Wood Surface Changes of Heat-Treated Cunninghamia lanceolate Following Natural Weathering
Authors: Cui Xinjie , Matsumura Junji
Published: September 2019

To quickly clarify the effect of heat treatment on weatherability of Cunninghamia lanceolate (Lamb.) Hook., we investigated the surface degradation under natural exposure. A comparison between heat-treated and untreated samples was taken based on surface color changes and structural decay at each interval. Over four weeks of natural exposure, multiple measurements were carried out. Results show that color change decreased in the order of 220 °C heat-treated > untreated > 190 °C heat-treated. The results also indicate that the wood surface color stability was improved via the proper temperature of thermal modification. Low vacuum scanning electron microscopy (LVSEM) results expressed that thermal modification itself had caused shrinking in the wood surface structure. From the beginning of the weathering process, the heat treatment affected the surface structural stability. After natural exposure, the degree of wood structure decay followed the pattern 220 °C heat-treated > 190 °C heat-treated > untreated. Therefore, when considering the impact on the structure, thermal modification treatment as a protective measure to prevent weathering was not an ideal approach and requires further improvement.
Evaluation of the Impacts of Climate Change on Sediment Yield from the Logiya Watershed, Lower Awash Basin, Ethiopia
Authors: Jilo Nura Boru , Gebremariam Bogale , Harka Arus Edo , Woldemariam Gezahegn Weldu , Behulu Fiseha
Published: September 2019

It is anticipated that climate change will impact sediment yield in watersheds. The purpose of this study was to investigate the impacts of climate change on sediment yield from the Logiya watershed in the lower Awash Basin, Ethiopia. Here, we used the coordinated regional climate downscaling experiment (CORDEX)-Africa data outputs of Hadley Global Environment Model 2-Earth System (HadGEM2-ES) under representative concentration pathway (RCP) scenarios (RCP4.5 and RCP8.5). Future scenarios of climate change were analyzed in two-time frames: 2020–2049 (2030s) and 2050–2079 (2060s). Both time frames were analyzed using both RCP scenarios from the baseline period (1971–2000). A Soil and Water Assessment Tool (SWAT) model was constructed to simulate the hydrological and the sedimentological responses to climate change. The model performance was calibrated and validated using the coefficient of determination (R2), Nash–Sutcliffe efficiency (NSE), and percent bias (PBIAS). The results of the calibration and the validation of the sediment yield R2, NSE, and PBIAS were 0.83, 0.79, and −23.4 and 0.85, 0.76, and −25.0, respectively. The results of downscaled precipitation, temperature, and estimated evapotranspiration increased in both emission scenarios. These climate variable increments were expected to result in intensifications in the mean annual sediment yield of 4.42% and 8.08% for RCP4.5 and 7.19% and 10.79% for RCP8.5 by the 2030s and the 2060s, respectively.
Validation of the Short-Form Health Literacy Questionnaire (HLS-SF12) and Its Determinants among People Living in Rural Areas in Vietnam
Authors: Duong Tuyen Van , Nguyen Thao T. P. , Pham Khue M. , Nguyen Kien T. , Giap Manh H. , Tran Tung D. X. , Nguyen Chi X. , Yang Shwu-Huey , Su Chien-Tien
Published: September 2019

Background: Health literacy (HL) is an important factor in improving health inequalities in poor and marginalized groups. Assessing comprehensive HL is critical. In this study, we validated the use of a comprehensive short-form HL survey tool (HLS-SF12) and examined the determinants of HL among people in rural areas. Methods: A cross-sectional study was conducted in July 2019 on 440 people residing in mountainous areas in Vietnam. Health literacy was measured using the HLS-SF12. Personal characteristics were also collected. We analyzed data using confirmatory factor analysis, internal consistency analysis, and regression analysis. Results: The questionnaire demonstrated a good construct validity with satisfactory goodness-of-fit indices and item-scale convergent validity. The tool was reliable and homogeneous with Cronbach’s alpha = 0.79, with no floor/ceiling effects. People who were married had lower HL (regression coefficient B = −3.12; 95% confidence interval (CI) = −5.69, −0.56; p = 0.017) compared with those who never married. Higher education attainment (B = 3.41 to 10.44; p < 0.001), a better ability to pay for medication (B = 4.17 to 9.89; p < 0.001), and a tendency to view health-related TV/radio more often (B = 5.23 to 6.15; p < 0.001) were associated with higher HL. Conclusions: The HLS-SF12 is a valid survey tool for the evaluation of HL in rural populations. A number of personal characteristics were strongly associated with HL.
The Relationship among Government, Enterprise, and Public in Environmental Governance from the Perspective of Multi-Player Evolutionary Game
Authors: Chen Yingxin , Zhang Jing , Tadikamalla Pandu R. , Gao Xutong
Published: September 2019

Environmental governance is an important component of the national governance system. China’s current environmental problems are particularly complex. How to let the government, enterprises, and the public participate in environmental governance is the key to enhance the ability of environmental governance. Based on the evolutionary game theory, the interaction and influencing factors among enterprise pollution control, government supervision, and public participation are analyzed, and the empirical analysis is carried out based on China’s 30 provincial panel data from 2009 to 2018. The research results show that government supervision has a positive effect on the environmental governance and can urge enterprises to actively perform pollution control. The effect of government supervision is constrained by the income and cost of enterprises, and the penalties for passive pollution control should be raised. At the same time, improving the government’s reputation loss can effectively stimulate the government’s environmental supervision behavior. Public participation significantly promotes the governance effect of three industrial wastes, and the enthusiasm of public participation is closely related to participation cost and psychological benefits. Public participation can replace government supervision to a certain extent. The interaction between government and public has a positive effect on environmental governance. The research results will help to build an effective environmental governance system and improve environmental governance performance and public satisfaction.
Association between Emotion Dysregulation and Distinct Groups of Non-Suicidal Self-Injury in Taiwanese Female Adolescents
Authors: Chen Wan-Lan , Chun Chin-Cha
Published: September 2019

Background: Previous studies revealed that female adolescents are more likely than males to engage in non-suicidal self-injury (NSSI) to regulate negative emotions; however, the dimensions of emotion regulation that are associated with NSSI behavior in adolescents require further examination. The present study aimed to identify Taiwanese female adolescent clusters with NSSI engagement frequency and to evaluate the association of specific forms of emotion dysregulation with NSSI. Methods: The participants were 438 female adolescents (mean age = 15.23 years, SD = 1.24, range between 13 and 18) recruited from 11 high schools. Self-report questionnaires assessing NSSI, difficulties in emotion regulation, and positive and negative affect were administered, and 37% of respondents reported a history of NSSI. Results: The analysis of NSSI frequency yielded three groups: severe, moderate, and non-NSSI. High negative affect, low positive affect, and difficulties in all aspects of emotion regulation differentiated female adolescents in the severe NSSI group from their counterparts in the non-NSSI group. The moderate and severe NSSI groups were further distinguished by age of onset, negative affect, emotion regulation strategies, and impulse control. Adolescents classified in the severe group reported earlier onset of NSSI, higher negative affect, less emotion regulation strategies, and more difficulty with impulse control. Conclusions: The results indicate that assessments of NSSI and emotion regulation should be incorporated in youth mental health screening. The clinical implications of NSSI behavior intervention require further discussion.
Non-Coding RNAs in Cartilage Development: An Updated Review
Authors: Razmara Ehsan , Bitaraf Amirreza , Yousefi Hassan , Nguyen Tina H. , Garshasbi Masoud , Cho William Chi-shing , Babashah Sadegh
Published: September 2019

In the development of the skeleton, the long bones are arising from the process of endochondral ossification (EO) in which cartilage is replaced by bone. This complex process is regulated by various factors including genetic, epigenetic, and environmental elements. It is recognized that DNA methylation, higher-order chromatin structure, and post-translational modifications of histones regulate the EO. With emerging understanding, non-coding RNAs (ncRNAs) have been identified as another mode of EO regulation, which is consist of microRNAs (miRNAs or miRs) and long non-coding RNAs (lncRNAs). There is expanding experimental evidence to unlock the role of ncRNAs in the differentiation of cartilage cells, as well as the pathogenesis of several skeletal disorders including osteoarthritis. Cutting-edge technologies such as epigenome-wide association studies have been employed to reveal disease-specific patterns regarding ncRNAs. This opens a new avenue of our understanding of skeletal cell biology, and may also identify potential epigenetic-based biomarkers. In this review, we provide an updated overview of recent advances in the role of ncRNAs especially focus on miRNA and lncRNA in the development of bone from cartilage, as well as their roles in skeletal pathophysiology.
Involvement of Vanin-1 in Ameliorating Effect of Oxidative Renal Tubular Injury in Dahl-Salt Sensitive Rats
Authors: Hosohata Keiko , Jin Denan , Takai Shinji , Iwanaga Kazunori
Published: September 2019

In salt-sensitive hypertension, reactive oxygen species (ROS) play a major role in the progression of renal disease partly through the activation of the mineralocorticoid receptor (MR). We have previously demonstrated that urinary vanin-1 is an early biomarker of oxidative renal tubular injury. However, it remains unknown whether urinary vanin-1 might reflect the treatment effect. The objective of this study was to clarify the treatment effect for renal tubular damage in Dahl salt-sensitive (DS) rats. DS rats (six weeks old) were given one of the following for four weeks: high-salt diet (8% NaCl), high-salt diet plus a superoxide dismutase mimetic, tempol (3 mmol/L in drinking water), high-salt diet plus eplerenone (100 mg/kg/day), and normal-salt diet (0.3% NaCl). After four-week treatment, blood pressure was measured and kidney tissues were evaluated. ROS were assessed by measurements of malondialdehyde and by immunostaining for 4-hydroxy-2-nonenal. A high-salt intake for four weeks caused ROS and histological renal tubular damages in DS rats, both of which were suppressed by tempol and eplerenone. Proteinuria and urinary N-acetyl-β-D-glucosaminidase exhibited a significant decrease in DS rats receiving a high-salt diet plus eplerenone, but not tempol. In contrast, urinary vanin-1 significantly decreased in DS rats receiving a high-salt diet plus eplerenone as well as tempol. Consistent with these findings, immunohistochemical analysis revealed that vanin-1 was localized in the renal proximal tubules but not the glomeruli in DS rats receiving a high-salt diet, with the strength attenuated by tempol or eplerenone treatment. In conclusion, these results suggest that urinary vanin-1 is a potentially sensitive biomarker for ameliorating renal tubular damage in salt-sensitive hypertension.
Induction of Articular Chondrogenesis by Chitosan/Hyaluronic-Acid-Based Biomimetic Matrices Using Human Adipose-Derived Stem Cells
Authors: Huang Yijiang , Seitz Daniel , König Fabian , Müller Peter E. , Jansson Volkmar , Klar Roland M.
Published: September 2019

Cartilage repair using tissue engineering is the most advanced clinical application in regenerative medicine, yet available solutions remain unsuccessful in reconstructing native cartilage in its proprietary form and function. Previous investigations have suggested that the combination of specific bioactive elements combined with a natural polymer could generate carrier matrices that enhance activities of seeded stem cells and possibly induce the desired matrix formation. The present study sought to clarify this by assessing whether a chitosan-hyaluronic-acid-based biomimetic matrix in conjunction with adipose-derived stem cells could support articular hyaline cartilage formation in relation to a standard chitosan-based construct. By assessing cellular development, matrix formation, and key gene/protein expressions during in vitro cultivation utilizing quantitative gene and immunofluorescent assays, results showed that chitosan with hyaluronic acid provides a suitable environment that supports stem cell differentiation towards cartilage matrix producing chondrocytes. However, on the molecular gene expression level, it has become apparent that, without combinations of morphogens, in the chondrogenic medium, hyaluronic acid with chitosan has a very limited capacity to stimulate and maintain stem cells in an articular chondrogenic state, suggesting that cocktails of various growth factors are one of the key features to regenerate articular cartilage, clinically.
Identification of Long Non-Coding RNAs and the Regulatory Network Responsive to Arbuscular Mycorrhizal Fungi Colonization in Maize Roots
Authors: Han Guomin , Cheng Chen , Zheng Yanmei , Wang Xuewen , Xu Yunjian , Wang Wei , Zhu Suwen , Cheng Beijiu
Published: September 2019

Recently, long noncoding RNAs (lncRNAs) have emerged as vital regulators of many biological processes in animals and plants. However, to our knowledge no investigations on plant lncRNAs which respond to arbuscular mycorrhizal (AM) fungi have been reported thus far. In this study, maize roots colonized with AM fungus were analyzed by strand-specific RNA-Seq to identify AM fungi-responsive lncRNAs and construct an associated regulatory network. A total of 1837 differentially expressed protein coding genes (DEGs) were identified from maize roots with Rhizophagus irregularis inoculation. Many AM fungi-responsive genes were homologs to MtPt4, STR, STR2, MtFatM, and enriched pathways such as fatty acid biosynthesis, response to phosphate starvation, and nitrogen metabolism are consistent with previous studies. In total, 5941 lncRNAs were identified, of which more than 3000 were new. Of those, 63 lncRNAs were differentially expressed. The putative target genes of differentially expressed lncRNAs (DELs) were mainly related to phosphate ion transmembrane transport, cellular response to potassium ion starvation, and lipid catabolic processes. Regulatory network analysis showed that DELs might be involved in the regulation of bidirectional nutrient exchange between plant and AM fungi as mimicry of microRNA targets. The results of this study can broaden our knowledge on the interaction between plant and AM fungi.
Ectopic Expression of a R2R3-MYB Transcription Factor Gene LjaMYB12 from Lonicera japonica Increases Flavonoid Accumulation in Arabidopsis thaliana
Authors: Qi Xiwu , Fang Hailing , Chen Zequn , Liu Zhiqi , Yu Xu , Liang Chengyuan
Published: September 2019

Lonicera japonica Thunb. is a widely used medicinal plant and is rich in a variety of active ingredients. Flavonoids are one of the important components in L. japonica and their content is an important indicator for evaluating the quality of this herb. To study the regulation of flavonoid biosynthesis in L. japonica, an R2R3-MYB transcription factor gene LjaMYB12 was isolated and characterized. Bioinformatics analysis indicated that LjaMYB12 belonged to the subgroup 7, with a typical R2R3 DNA-binding domain and conserved subgroup 7 motifs. The transcriptional level of LjaMYB12 was proportional to the total flavonoid content during the development of L. japonica flowers. Subcellular localization analysis revealed that LjaMYB12 localized to the nucleus. Transactivation activity assay indicated that LjaMYB12 was a transcriptional activator. Then, ectopic expression of LjaMYB12 in Arabidopsis could increase PAL activity and flavonoid content and promote transcription of a range of flavonoid biosynthetic genes. Interestingly, the fold changes of downstream genes in the flavonoid biosynthetic pathway were significantly higher than that of the upstream genes, which suggested that LjaMYB12 may have different regulatory patterns for the upstream and downstream pathways of flavonoid biosynthesis. The results provided here will effectively facilitate the study of subgroup 7 MYBs and transcriptional regulation of flavonoid biosynthesis in L. japonica.
Chemoresistance in Pancreatic Cancer
Authors: Zeng Siyuan , Pöttler Marina , Lan Bin , Grützmann Robert , Pilarsky Christian , Yang Hai
Published: September 2019

Pancreatic ductal adenocarcinoma (PDAC), generally known as pancreatic cancer (PC), ranks the fourth leading cause of cancer-related deaths in the western world. While the incidence of pancreatic cancer is displaying a rising tendency every year, the mortality rate has not decreased significantly because of late diagnosis, early metastasis, and limited reaction to chemotherapy or radiotherapy. Adjuvant chemotherapy after surgical resection is typically the preferred option to treat early pancreatic cancer. Although 5-fluorouracil/leucovorin with irinotecan and oxaliplatin (FOLFIRINOX) and gemcitabine/nab-paclitaxel can profoundly improve the prognosis of advanced pancreatic cancer, the development of chemoresistance still leads to poor clinical outcomes. Chemoresistance is multifactorial as a result of the interaction among pancreatic cancer cells, cancer stem cells, and the tumor microenvironment. Nevertheless, more pancreatic cancer patients will benefit from precision treatment and targeted drugs. Therefore, we outline new perspectives for enhancing the efficacy of gemcitabine after reviewing the related factors of gemcitabine metabolism, mechanism of action, and chemoresistance.
Coptic Language Learning and Social Media
Authors: Deschene D. Nicole
Published: September 2019

This study explored the potential of using the Internet, including existing social media platforms, for Coptic language learning. Through global exposure, endangered language maintenance and revitalization efforts may benefit from having a presence on social media. The researcher created Coptic language learning material, social media accounts on multiple platforms, and a website. Data were collected through a survey with questions focused on social media users’ background and experience with the Coptic language learning material. In addition to the survey, analytics from the social media and website platforms were documented. The results indicated that social media provided a global audience and the Coptic language learning material blended into survey respondents’ daily lives with positive acceptance.
Control of Laves Precipitation in a FeCrAl-based Alloy Through Severe Thermomechanical Processing
Authors: Zheng Jiyun , Jia Yuzhen , Du Peinan , Wang Hui , Pan Qianfu , Zhang Yiyong , Liu Chaohong , Zhang Ruiqian , Qiu Shaoyu
Published: September 2019

In recent years, the development of nuclear grade FeCrAl-based alloys with enhanced accident tolerance has been carried out for light water reactor (LWR) fuel cladding to serve as a substitute for zirconium-based alloys. To achieve excellent microstructure stability and mechanical properties, the control of precipitation particles is critical for application of FeCrAl-based alloys. In this paper, the effect of thermomechanical processing on the microstructure and precipitation behavior of hot-rolled FeCrAl alloy plates was examined. After hot rolling, the FeCrAl alloy plates had typical deformation textures. The rolling direction (RD) orientation gradually rotated from <100> to <110> along with increasing reduction. Shear bands and cell structures were formed in the matrix, and the former acted as preferable nucleation sites for crystallization. Improved deformation helped to produce strain-induced precipitation. The plate with 83% reduction had the most homogeneous and finest precipitation particles. Identification results by TEM indicated that the Laves precipitation was of the Fe2Nb-type crystal structure type, with impurities including Mo, Cr, and Si. The plate with uniform Laves particles displayed favorable heat stability after a long period of aging at 800 °C. The microstructure evolution of the aged sample was also observed. The deformation microstructure and the strain-induced precipitation mechanism of FeCrAl alloys are discussed.
Comparative Study on Viscoelastic Evaluation Methods of Polymer Materials Based on Ultrasonic Method
Authors: Li Yuan-yuan , Chang Jun-jie , Huang Lin , Tang Yong-hui
Published: September 2019

Rubber, as a kind of macromolecular material often used in large ships, aviation, aerospace, and other fields, has remarkable viscoelasticity at room temperature. Therefore, it is of great significance to evaluate the viscoelastic properties of polymer composites. In this paper, four kinds of rubber materials are taken as research objects. Based on the principle of ultrasonic detection, the viscoelastic evaluation of the sample materials is carried out through experiments and simulations. On the basis of previous research, the surface reflection method (SRM) and the bottom reflection method (BRM) are compared in depth. First, the spectrum of received signals is analyzed, and the storage elastic modulus, loss elastic modulus, attenuation coefficient and loss tangent value are obtained. Secondly, the results of the BRM and the SRM are compared and analyzed in the frequency domain of –6 dB. The results show that both the SRM and BRM are feasible in the evaluation of the viscoelasticity of the material, and the variation trends observed for the above-mentioned parameters in the effective frequency domain are consistent, especially at the center frequency. Finally, aiming at the mode transformation of the acoustic wave around the ultrasonic sensor, the practical performance of the surface reflection method is optimized by increasing the diameter of the ultrasonic sensor.
The Effect of Frankel’s Stabilization Exercises and Stabilometric Platform in the Balance in Elderly Patients: A Randomized Clinical Trial
Authors: Mańko Grzegorz , Pieniążek Magdalena , Tim Sabina , Jekiełek Małgorzata
Published: September 2019

Background and Objectives: Every year, older people are becoming a larger part of the population. In a couple of years medicine is going to struggle with specific disorders and their consequences, where one of them are falls. Fall prevention involves a use of strengthening exercises, equivalent exercises, stabilometric platforms, and special exercise programs. Almost the entire brain is involved in maintaining correct balance. Reduction of a volume of gray matter negatively affects balance. Single exercise sessions do not significantly improve balance. In order to achieve satisfactory results at least 10 training sessions are required. The aim of this study is to determine if there is a correlation between a risk of falls, gender, and a risk of falls and the age of the subjects. Another reason to conduct that research was to assess the effectiveness of Frankel’s exercises and training of using the stabilometric platform in rehabilitation, which aims to reduce the risk of falls among elderly people. Materials and Methods: The study involved 40 elderly patients referred for physiotherapy to a rehabilitation center. The patients were divided into two groups of 20 people. In experimental group 1 (C) Frankel’s stabilization exercises were used; in experimental group 2 (E) a stabilometric platform was used. The correlation between the risk of falls and age as well a risk of falling and the gender of the examined persons was taken into consideration. The effect of therapy that uses stabilization exercises and the stabilometric platform on the risk of falls in the examined persons was assessed using the Tinetti scale. Clinical control was performed using the Tinetti scale, before and after a two-week rehabilitation period. Results: The study showed no correlation between the degree of risk of falling and age, and between the risk of falling by the elderly and gender. There were also changes in the results obtained by patients after using the training, both with the use of Frankel’s stabilization exercises as well as with the use of the stabilometric platform. Patients using the dynamometric platform obtained higher results in the Tinetti test after treatment. Conclusions: In the examined sample, no correlation was found between the risk of falls and age as well as the risk of falls and gender. Both Frankel’s exercises and training with the use of the stabilometric platform were effective in a rehabilitation program aimed at reducing the risk of falls among the elderly.
Permeable Water-Resistant Heat Insulation Panel Based on Recycled Materials and Its Physical and Mechanical Properties
Authors: Hýsek Štěpán , Frydrych Miroslav , Herclík Miroslav , Fridrichová Ludmila , Louda Petr , Knížek Roman , Le Van Su , Le Chi Hiep
Published: September 2019

This paper deals with the development and characteristics of the properties of a permeable water-resistant heat insulation panel based on recycled materials. The insulation panel consists of a thermal insulation core of recycled soft polyurethane foam and winter wheat husk, a layer of geopolymer that gives the entire sandwich composite strength and fire resistance, and a nanofibrous membrane that permits water vapor permeability, but not water in liquid form. The observed properties are the thermal conductivity coefficient, volumetric heat capacity, fire resistance, resistance to long-term exposure of a water column, and the tensile strength perpendicular to the plane of the board. The results showed that while the addition of husk to the thermal insulation core does not significantly impair its thermal insulation properties, the tensile strength perpendicular to the plane of these boards was impaired by the addition of husk. The geopolymer layer increased the fire resistance of the panel for up to 13 min, and the implementation of the nanofibrous membrane resulted in a water flow of 154 cm2 in the amount of 486 g of water per 24 h at a water column height of 0.8 m.
Experimental and DFT Study of the Photoluminescent Green Emission Band of Halogenated (−F, −Cl, and −Br) Imines
Authors: Melendez Francisco J. , Castro María Eugenia , Portillo-Moreno Oscar , Hernández-Téllez Guadalupe , Moreno-Morales Gloria E. , Gutiérrez-Argüelles Daniela , Palomino-Merino Rodolfo , Rubio-Rosas Efraín , Gutiérrez-Pérez René
Published: September 2019

The morphological, optical, and structural changes in crystalline chiral imines derived from 2-naphthaldehyde as a result of changing the −F, −Cl, and −Br halogen (−X) atoms are reported. Scanning electron microscopy (SEM), optical absorption, photoluminescence (PL), and powder X-ray diffraction (XRD) studies were performed. Theoretical results of optical and structural properties were calculated using the PBE1PBE hybrid functional and compared with the experimental results. Differences in surface morphology, absorbance, XRD, and PL of crystals were due to the change of halogen atoms in the chiral moiety of the imine. Absorption spectra exhibited the typical bands of the naphthalene chromophore located in the ~200–350 nm range. Observed absorption bands in the UV region are associated with π→π* and n→π* electronic transitions. The band gap energy was calculated using the Tauc model. It showed a shift in the ~3.5–4.5 eV range and the crystals exhibited different electronic transitions associated with the results of absorbance in the UV region. XRD showed the monoclinic→orthorhombic crystalline phase transition. PL spectra displayed broad bands in the visible region and all the samples have an emission band (identified as a green emission band) in the ~400–750 nm range. This was associated with defects produced in the morphology, molecular packing, inductive effect and polarizability, crystalline phase transition, and increase in size of the corresponding halogen atoms; i.e., changes presumably induced by −C−X…X−, −C−X…N−, −C−N…π, and −C−X…π interactions in these crystalline materials were associated with morphological, optical, and structural changes.
Structural Insights into the Regulation Mechanism of Small GTPases by GEFs
Authors: Toma-Fukai Sachiko , Shimizu Toshiyuki
Published: September 2019

Small GTPases are key regulators of cellular events, and their dysfunction causes many types of cancer. They serve as molecular switches by cycling between inactive guanosine diphosphate (GDP)-bound and active guanosine triphosphate (GTP)-bound states. GTPases are deactivated by GTPase-activating proteins (GAPs) and are activated by guanine-nucleotide exchange factors (GEFs). The intrinsic GTP hydrolysis activity of small GTPases is generally low and is accelerated by GAPs. GEFs promote GDP dissociation from small GTPases to allow for GTP binding, which results in a conformational change of two highly flexible segments, called switch I and switch II, that enables binding of the gamma phosphate and allows small GTPases to interact with downstream effectors. For several decades, crystal structures of many GEFs and GAPs have been reported and have shown tremendous structural diversity. In this review, we focus on the latest structural studies of GEFs. Detailed pictures of the variety of GEF mechanisms at atomic resolution can provide insights into new approaches for drug discovery.
Octadecaneuropeptide (ODN) Induces N2a Cells Differentiation through a PKA/PLC/PKC/MEK/ERK-Dependent Pathway: Incidence on Peroxisome, Mitochondria, and Lipid Profiles
Authors: Namsi Amira , Nury Thomas , Khan Amira. S. , Leprince Jérôme , Vaudry David , Caccia Claudio , Leoni Valerio , Atanasov Atanas G. , Tonon Marie-Christine , Masmoudi-Kouki Olfa , Lizard Gérard
Published: September 2019

Neurodegenerative diseases are characterized by oxidative stress, mitochondrial damage, and death of neuronal cells. To counteract such damage and to favor neurogenesis, neurotrophic factors could be used as therapeutic agents. Octadecaneuropeptide (ODN), produced by astrocytes, is a potent neuroprotective agent. In N2a cells, we studied the ability of ODN to promote neuronal differentiation. This parameter was evaluated by phase contrast microscopy, staining with crystal violet, cresyl blue, and Sulforhodamine 101. The effect of ODN on cell viability and mitochondrial activity was determined with fluorescein diacetate and DiOC6(3), respectively. The impact of ODN on the topography of mitochondria and peroxisomes, two tightly connected organelles involved in nerve cell functions and lipid metabolism, was evaluated by transmission electron microscopy and fluorescence microscopy: detection of mitochondria with MitoTracker Red, and peroxisome with an antibody directed against the ABCD3 peroxisomal transporter. The profiles in fatty acids, cholesterol, and cholesterol precursors were determined by gas chromatography, in some cases coupled with mass spectrometry. Treatment of N2a cells with ODN (10−14 M, 48 h) induces neurite outgrowth. ODN-induced neuronal differentiation was associated with modification of topographical distribution of mitochondria and peroxisomes throughout the neurites and did not affect cell viability and mitochondrial activity. The inhibition of ODN-induced N2a differentiation with H89, U73122, chelerythrine and U0126 supports the activation of a PKA/PLC/PKC/MEK/ERK-dependent signaling pathway. Although there is no difference in fatty acid profile between control and ODN-treated cells, the level of cholesterol and some of its precursors (lanosterol, desmosterol, lathosterol) was increased in ODN-treated cells. The ability of ODN to induce neuronal differentiation without cytotoxicity reinforces the interest for this neuropeptide with neurotrophic properties to overcome nerve cell damage in major neurodegenerative diseases.
Therapeutic Effects of Anthocyanins for Vision and Eye Health
Authors: Nomi Yuri , Iwasaki-Kurashige Keiko , Matsumoto Hitoshi
Published: September 2019

Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. And AC passes through the blood-aqueous fluid barrier and blood-retinal barrier. In vitro study, AC had a relaxing effect on ciliary muscle which is important to treat both myopia and glaucoma. And AC stimulate the regeneration of rhodopsin in frog rod outer segment. Furthermore, AC could inhibit the axial length and ocular length elongation in a negative lens-induced chick myopia model. In addition, we summarized clinical studies of AC intake improved dark adaptation and transient myopic shift and the improvement on retinal blood circulation in normal tension glaucoma patients.
Bimodal Porosity and Stability of a TiO2 Gig-Lox Sponge Infiltrated with Methyl-Ammonium Lead Iodide Perovskite
Authors: Sanzaro Salvatore , Zontone Federico , Grosso David , Bottein Thomas , Neri Fortunato , Smecca Emanuele , Mannino Giovanni , Bongiorno Corrado , Spinella Corrado , La Magna Antonino , Alberti Alessandra
Published: September 2019

We created a blend between a TiO2 sponge with bimodal porosity and a Methyl-Ammonium Lead Iodide (MAPbI3) perovskite. The interpenetration of the two materials is effective thanks to the peculiar sponge structure. During the early stages of the growth of the TiO2 sponge, the formation of 5–10 nm-large TiO2 auto-seeds is observed which set the micro-porosity (<5 nm) of the layer, maintained during further growth. In a second stage, the auto-seeds aggregate into hundreds-of-nm-large meso-structures by their mutual shadowing of the grazing Ti flux for local oxidation. This process generates meso-pores (10–100 nm) treading across the growing layer, as accessed by tomographic synchrotron radiation coherent X-ray imaging and environmental ellipsometric porosimetry. The distributions of pore size are extracted before (>47% V) and after MAPbI3 loading, and after blend ageing, unfolding a starting pore filling above 80% in volume. The degradation of the perovskite in the blend follows a standard path towards PbI2 accompanied by the concomitant release of volatile species, with an activation energy of 0.87 eV under humid air. The use of dry nitrogen as environmental condition has a positive impact in increasing this energy by ~0.1 eV that extends the half-life of the material to 7 months under continuous operation at 60 °C.
Dietary Intake and Type 2 Diabetes
Authors: Ojo Omorogieva
Published: September 2019

This editorial aims to examine the risk factors associated with type 2 diabetes and to discuss the evidence relating to dietary strategies for managing people with this condition. It is clear from the evidence presented that a range of dietary interventions can provide useful approaches for managing people with type 2 diabetes, including the regulation of blood glucose and lipid parameters, and for reducing the risks of acute and chronic diabetic complications.
The West Nickel Mines Amish School Murders and the Cultural Fetishization of “Amish Forgiveness”
Authors: Metcalfe Darcy
Published: September 2019

In the days and weeks following the West Nickel Mines Amish school murders, hegemonic U.S. cultural discourse largely fetishized the Amish response of forgiveness in revealing ways. Within this discourse, the terrorist attacks of 11 September 2001 were referenced in articles and commentaries which sought to weigh the moral value of forgiveness in response to extreme violence. In this way, understandings of Amish forgiveness were largely “strip-mined” from the Nickel Mines community and “transported wholesale” to other counter-cultural settings. In dominant U.S. capitalistic and consumeristic culture, Amish forgiveness quickly became a fluctuating material commodity that was fetishized in ways which revealed the destabilized moral consciousness of a nation. Dominant cultural discourse exposed this destabilization while it also worked to interrogate it. I conclude that the fetishization of forgiveness following the Amish school murders reflected collective concerns that reached far beyond the immediate context of the Nickel Mines Amish community. The U.S. cultural fetishization of forgiveness revealed, instead, a cultural consciousness that desperately sought relief from the chaos and confusion of what it means to be a citizen of nation that exists in and by the normativity of extreme violence.
Fractal Study of the 1997–2017 Italian Seismic Sequences: A Joint Analysis of Seismological Data and DInSAR Measurements
Authors: Valerio Emanuela , De Novellis Vincenzo , Manzo Mariarosaria , Tizzani Pietro
Published: September 2019

During the last 20 years (1997 to 2017), four seismic sequences with Mw ≥ 5.5 mainshocks nucleated along the Central and Northern Apennines chain (Italy), causing casualties and damage: the 1997 Colfiorito, the 2009 L’Aquila, the 2012 Emilia, and the most recent 2016–2017 Central Italy seismic sequences. In this work, we perform a novel joint analysis of seismological and remote-sensing data to achieve new insights into the faulting process evolution during the considered seismic sequences. To this aim, we study these seismic sequences by exploiting the available seismological data and by applying fractals theory to them. In particular, we characterize the different behavior of compressional and extensional seismic sequences by examining the temporal evolution of the fractal dimension values. In addition, we compare the Differential Synthetic Aperture Radar Interferometry (DInSAR) displacement maps relevant to the considered seismic events (already published in our past papers) and the performed spatial and temporal seismological analyses, in order to emphasize some significant aspects of the different faulting processes active during these Italian seismic sequences. The analysis of the fractal dimension values shows that over time extensional seismic sequences are spatially distributed within a volume, whereas compressional ones are aligned along a preferential surface. These spatio-temporal patterns are confirmed by: (1) the spatial distribution of hypocenters for the events that occurred between the mainshock and the post-seismic synthetic aperture radar (SAR) acquisition; (2) the spatial extension of coseismic DInSAR ground-deformation patterns. The proposed seismic and ground-deformation analyses can thus typify different geodynamic contexts in Italy, providing a distinct image of articulated faulting processes.
LEO Precise Orbit Determination with Inter-satellite Links
Authors: Li Xingxing , Jiang Zihao , Ma Fujian , Lv Hongbo , Yuan Yongqiang , Li Xin
Published: September 2019

Traditional precise orbit determination (POD) for low Earth orbit (LEO) satellites relies on observations from ground stations and onboard receivers. Although the accuracy can reach centimeter level, there are still problems such as insufficient autonomous operation capability. The inter-satellite link (ISL) is a link used for communication between satellites and has a function of dual-way ranging. Numerous studies have shown that observational data using ISLs can be adopted for POD of navigation satellites. In this contribution, we mainly focus on LEO satellites POD with ISLs. First, we design LEO constellations with different numbers of satellites and ISL measurements, based on which the constellations are simulated. Then rough tests of POD using different link topologies are carried out. The results show that in the 60-LEO constellation the average 3-dimensional (3D) orbital errors are 0.112 m using “4-connected” link topology with constant 4 links per satellite and 0.069 m using “all-connected” link topology with theoretically maximum numbers of links. After that, we carry out refined POD experiments with several sets of satellite numbers and different observation accuracy. The results show the higher link ranging accuracy and the more numbers of links bring higher POD precision. POD with ISLs gets bad performance in the case of center of gravity reference when link ranging accuracy is poor and numbers of links are small. When the link accuracy is 40 cm, average 3D orbital errors of 60-LEO constellation are 0.358 m, which can only meet the demand of autonomous navigation. With the constraint of the right ascension of the ascending node (RAAN), POD using ISLs reaches an extremely high precision when adopting a spatial reference provided by navigation satellites. For 120-LEO constellation, the average 3D orbital errors are 0.010 m; for 192-LEO constellation, the errors are 0.006 m.
A Separated Receptor/Transducer Scheme as Strategy to Enhance the Gas Sensing Performance Using Hematite–Carbon Nanotube Composite
Authors: Hieu Nguyen Minh , Phuoc Cao Van , Hien Truong Thi , Chinh Nguyen Duc , Quang Nguyen Duc , Kim Chunjoong , Jeong Jong-Ryul , Kim Dojin
Published: September 2019

Nanocomposite structures, where the Fe, Fe2O3, or Ni2O3 nanoparticles with thin carbon layers are distributed among a single-wall carbon nanotube (SWCNT) network, are architectured using the co-arc discharge method. A synergistic effect between the nanoparticles and SWCNT is achieved with the composite structures, leading to the enhanced sensing response in ammonia detection. Thorough studies about the correlation between the electric properties and sensing performance confirm the independent operation of the receptor and transducer in the sensor structure by nanoparticles and SWCNT, respectively. Nanoparticles with a large specific surface area provide adsorption sites for the NH3 gas molecules, whereas hole carriers are supplied by the SWCNT to complete the chemisorption process. A new chemo-resistive sensor concept and its operating mechanism is proposed in our work. Furthermore, the separated receptor and transducer sensor scheme allows us more freedom in the design of sensor materials and structures, thereby enabling the design of high-performance gas sensors.