bluuebunny/crossref_metadata_2025 huggingface dataset:
PERIPARTUM HYSTERECTOMY -INCIDENCE, INDICATIONS, RISK FACTORS AND OUTCOMES AT A TERITIARY CARE HOSPITAL
Authors: Sowjanya Ravella , Vijaya Sheela Polinati , Sai Praneetha Reddy Ch , Aruna Gollapalli , Usha Prasad
Published: August 2022

Introduction: Peripartum hysterectomy is defined as a hysterectomy performed at the time, or within 24 hours, of delivery. It is a life saving procedure and becomes necessary when all medical and surgical methods fail to control bleeding. It is associated with significant maternal morbidity and mortality. Objectives: To determine the incidence, indications, maternal and perinatal outcome of peripartum hysterectomy Methods: A retrospective hospital based observational study of all women who underwent peripartum hysterectomy over a period of 2 years from January 2020 to December 2021 in the department of Obstetrics and Gynaecology, SIDDARTHA MEDICAL COLLEGE, VIJAYAWADA. Results: A total of 20 peripartum hysterectomies were done during the study period. Incidence was 1.08/1000 deliveries. Main indications of peripartum hysterectomy were uterine atony (45%), abnormal placentation (30%), and uterine rupture (10%). Total abdominal hysterectomy was done in 15% cases and subtotal hysterectomies were done in 85% cases. There was one maternal death (5%) and 5 perinatal deaths (25%). Conclusion: Atonic uterus is the commonest indication for peripartum hysterectomy. Previous scar, multiparity and abnormal placentation were the significant risk factors.
RULE OF LAW PRINCIPLE AS A PRINCIPLE OF CRIMINAL PROCEDURE (ON MATERIALS OF THE EUROPEAN COURT OF HUMAN RIGHTS)
Authors:   Assistant Professor of Law Institute of Law, Nirma University., D. Devarhubli Gururaj , Sarfaraj Patel Bushra ,   Student of 4th Year, 8th Semester B.A.LL.B. Parul Institute of Law, Parul University.
Published: August 2022

The urgency of the study is stipulated by the importance of the European Court of Human Rights practice studying in order to determine the content of the rule of law principle. The purpose of the article is to elucidate the rule of law principle as a principle of criminal procedure by means of the European Court of Human Rights practice. The study is based on the paradigm of human rights priority over positive law and understanding of law, formed within the natural law school, distinguishing between law and the law, and judicial precedent, legal doctrine and principles of law are recognized as the forms of law. The study of the European Court of Human Rights practice led to the use of content analysis method and the hermeneutic method. The article clarifies that the pluralism of approaches to understanding the rule of law does not preclude the identification of ideas constituting the rule of law and are named in most of the rule of law theories, including the following: no one can be punished other than for a crime no one can be above the law, all people are equal before the law and the court court practice, disclosing the content of legal requirements, is a source of law it is substantiated that the provisions of the European Court of Human Rights on criminal proceedings reflect the commitment to democratic values, and their purpose is to ensure the rights and fundamental freedoms of subjects to criminal proceedings, prevent disproportionate interference with human rights by public authorities, and implement the rule of law principle. The materials of the article can be used to improve the public authoritys activities in the field of crime prevention through the implementation of the following areas: study of the European Court of Human Rights practice by crime prevention bodies constant monitoring of the European Court of Human Rights practice in order to improve national legislation.
IDI-75 - AN OPTIMAL ONES ASSIGNMENT METHOD FOR SOLVING UNBALANCED ASSIGNMENT PROBLEMS
Authors:   Associate Professor, Department of Mathematics, St. Johns College, Palayamkottai-627002, Affiliated to Manonmaniam Sundaranar University, Tirunelveli-627012, Tamil Nadu, India., Murugesan R.
Published: August 2022

In this article, a new technique namely IDI-75 (named to commemorate the 75th Independence Day of India), which is a simplified form of the existing Ones Assignment Method (OAM) of solving assignment problems, finds the optimal solution to a given unbalanced assignment problem (UAP). In the OAM, it is required to convert the given UAP into a balanced one by introducing one dummy row or column with 1 unit of effectiveness in each cell. But, the IDI-75 technique can be applied directly on the given UAP without converting it into a balanced one. The technique requires only row minimum division operation or only column minimum division operation depending on the size of rows and columns in order to have at least one 1-entry in each of the required number of rows and/or columns only. The assignments are made on the appropriate 1-entry cells of reduced ratio of costs matrix. To test the validity and effectiveness of the IDI-75 technique, 20 benchmark instances with different sizes from the literatures have been tested. Simulation results authenticate that the technique IDI-75 is the best one which produces optimal solution to all 20 instances. Therefore, it is clever to apply the IDI-75 technique to solve the UAPs as it is very simple, easy to understand, easy to apply and consume less time in comparison to the existing OAM.
FUNDUS FINDINGS IN PATIENTS OF MILD, MODERATE AND SEVERE DEGREE OF ANAEMIA PRESENTING TO THE TERTIARY HEALTH CARE CENTRE
Authors:   Professor & Head, Dept. of ophthalmology, MLB Medical College Jhansi, India., Kumar Jitendra , Jain Apurva ,   Junior Resident, Dept. of ophthalmology, MLB Medical College Jhansi, India., Kumari Rashmi ,   Junior Resident, Dept. of ophthalmology, MLB Medical College Jhansi, India.
Published: August 2022

Purpose:To study fundus findings in patients of mild,moderate, and severe degree of anaemia presenting to the tertiary health care centre. Methods:This was a prospective observational study that involved25 patients of anemiacomplaining of blurring of vision, conjunctival pallor, pain, subconjunctival hemorrhage and eyelid swelling. Results:There were 20females and 5 males and the age group taken was 20 to 50 years.Out of 25 patients of nutritional anemia, 12 patients belonged to the age group of 20 to 30 years, out of which 10 were females and 2 weremales. 8 patients belonged to age group of 30 to 40 years, out of which 6 were females and 2 were males. 5 patients belonged to the age group of 40 to 50 years, out of which 4 were females and 1 was male.In our study, it was found that 5 patients belonged to the category of severe anemia with hemoglobin [<6 gm/dl], 8 patients belonged to the category of moderate anemia with hemoglobin ranging between 6-10 gm/dl, 12 patients belonged to the category of mild anemia with hemoglobin ranging between 10-12 gm/dl.On looking for various fundus manifestations in different grades of anemia viz.mild, moderate and severe anemia, we found out that the incidence of retinal vascular changes in the form of venous dilation and tortuosity, pale disc, roth spots, macular edema,subhyaloid hemorrhages, dot Ã¢Â€Â“ blot and flame shaped hemorrhages showed an increasing trend with increase in severity of anemia. Conclusion:There is a high prevalence of anemia in India which affects female gender more than male gender. Anemic retinopathy is not an uncommon condition but it is generally asymptomatic and gets noted incidentally during general workup of the patients. It has variable presentation in different patients with different grades of anemia.
DEEP LEARNING-BASED BRAIN TUMOR DETECTION
Authors:   DepartmentofComputer ScienceandEngineering,SRUniversity,Warangal,Telangana,India., Amaan Mohd , Saboor Shariqha ,   Department of Pharmaceutics, Chaitanya College of Pharmacy Education and Research, Warangal, Telangana, India., Ahad Hussain Syed ,   Department of Pharmacology, Vaageswari College of Pharmacy, Karimnagar,Telangana, India.
Published: August 2022

A group of aberrant brain cells is known as a brain tumor. Brain tumors can be either malignant or benign. Whereas benign is not cancerous, malignant is. Both tumors are extremely dangerous because they spread quickly and affect many areas of the brain. About 166,039 people in the US had brain tumors or other cancers of the central nervous system in 2015.Even afterseveral researches,the cause of braintumorisunknown. We aimed to detect the brain tumor through image processing usingimages of MRI scans. Using Convolutional Neural Network(CNN) to perform imagebased classification. On receiving the image from the MRI scan as input, CNN will assess if the person has a brain tumor or not.It is observed on experimentation that the proposed approach needs an input image of size of240*240. Any image of another size cannot be used and the input image should only be a grayscale image. Color image cannot be used as an input image. The model which we proposed canbe further improved by using any size image as input. Moreover, the accuracy which we gotthrough this CNN model is 0.88. The model can be further improved by some changes so thataccuracy can be increased further.
UNE DYSPNEE AIGUE REVELATRICE DUN SYNDROME DE MOUNIER-KUHN : A PROPOS DUN CAS ET REVUE DE LITTERATURE
Authors:   Departement Pneumophtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., A. Anissa-Sahan Abdoulkader , Rachida Zahraoui ,   Departement Pneumophtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., Madina Rabileh ,   Departement Radiologie, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., Billah Nabil Moatassim ,   Departement Radiologie, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., Mouna Soualhi ,   Departement Pneumophtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., Hanane Charaf ,   Departement Pneumophtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc., Bourkadi Jamaleddine ,   Departement Pneumophtisiologie, Hopital Moulay Youssef, CHU Ibn Sina, Universite Mohammed V, Rabat, Maroc.
Published: August 2022

Mounier-Kuhn syndrome (MKS) is a rare entitycharacterised by an enlargedtrachea and main bronchi.Despite the century-long delaybetween the first description in 1932, itisstillunder-diagnosedwithonly 300 cases reported in the literature. Histologicallyitischaracterised by an atrophy of the smooth muscle and elastic fibres of the tracheobronchialtreeresulting in impairedmucociliary clearance. The respiratorysymptoms of MKS are non-specific and appear as a recurrentrespiratory infection. Chest CT remains the gold standard for diagnosistreatmentis non-specific and based on the control of associatedrespiratorydiseases, physiotherapy and sometimessurgery. We report here the case of a 61-year-old man with a history of chronicbronchitis and recurrentpneumonitiswhowasadmitted for acute dyspnea and in whom the diagnosis of MKSwasretained. A betterknowledge of the pathologywillallow an earlydiagnosis and prevention of complications. This case illustrates the latediagnosis and management.
Role-playing group counseling in character-strengthening education in high school students
Authors: Habsy Bakhrudin All
Published: August 2022

Purpose - This research aims to measure the effectiveness of counseling groups using the technique of role-playing in the framework of character-strengthening education in high school students.Method - research type used is quantitative with a quasi-experimental design. This study involves two object groups: experiment group and control group. These groups are set through a random method.Result - Counseling group with role-playing technique is proven to be effective in strengthening the character of the participants. This can be seen from the paired sample T-test where the significance score was 0.000 (p0.05). Thus, strengthening the character through a role-playing technique that includes the score of religious, nationalist, independent, mutual cooperation, and integrity shows significant changes in the results. _Implications - This study the impact on the development of service guidance and counseling in high school as an effort to build character’s participants teach to fit with the score of character education.Originality - This research is strengthening character education through counseling group service with a role-playing technique for high school students.***Purpose - Penelitian ini bertujuan untuk mengukur efektifitas konseling kelompok menggunakan teknik role playing dalam rangka penguatan pendidikan karakter pada siswa Sekolah Menengah Atas (SMA).Method - Jenis penelitian yang digunakan adalah kuantitatif dengan desain quasi eksperimen. Penelitian ini melibatkan dua objek kelompok yakni kelompok eksperimen dan kelompok kontrol. Penentuan kelompok ditetapkan melalui metode acak.Result - Konseling kelompok dengan teknik role playing terbukti efektif dalam penguatan karakter peserta didik. Hal ini terlihat dari uji paired sample T-test dimana nilai signifikansi menunjukkan angka 0,000 (p0,05). Dengan demikian, penguatan karakter melalui teknik role playing yang meliputi nilai religius, nasionalis, mandiri, gotong-royong dan integritas menunjukkan hasil perubahan yang signifikan.Implications - Kajian ini berdampak pada pengembangan layanan bimbingan dan konseling di SMA sebagai upaya penanaman karakter peserta didik agar sesuai dengan nilai pendidikan karakter.Originality - Penelitian ini merupakan kajian penguatan pendidikan karakter melalui layanan konseling kelompok dengan teknik role playing pada siswa SMA.
The relationship between problematic internet use and parenting models in the junior high school students in the pandemic era
Authors: Rahmawati Ajeng Intan Nur , Ariffudin Imam
Published: August 2022

Purpose: This study aims to analyze the relationship and the influence of parental parenting on students' PIU levels.Method: Correlational research with an explanatory design was chosen to answer the formulation of the research problem. A total of 121 junior high schools (SMP) students in Malang City were respondents to the study using random sampling. The research data was collected using two instruments, namely generalized problematic Internet Use Scale 2 (GPIUS2) and the Parenting Questionnaire in Alabama. The collected data were analyzed using multiple regression.Result: The results showed that inconsistent discipline, poor monitoring/supervision, and corporal punishment are variables that predict an increase in student PIU. Thus, it can be concluded that parental parenting is related and has an effect on the high and low levels of PIU.Implication: Therefore, parents need to adjust parenting by helping students in improving self-control during a pandemic that uses more internet access.Originality: This research is a study that focuses on analyzing problems that arise in the pandemic era related to problematic internet use (PIU) and parental parenting models.***Tujuan: Penelitian ini bertujuan untuk menganalisis hubungan dan pengaruh Problematic Internet Use (PIU) terhadap pola asuh orang tua pada siswa SMA Kota Malang.Metode: Correlational research with explanatory design was chosen to answer the formulation of the research problem. A total of 121 junior high school (SMP) students in Malang City were respondents to the study using random sampling. The research data was collected using two instruments, namely generalized problematic Internet Use Scale 2 (GPIUS2) and Parenting Questionairre Alabama. The collected data were analyzed using multiple regression analysis.Hasil: Hasil penelitian menunjukkan bahwa model pola asuh memiliki hubungan dan berpengaruh terhadap tingkat penggunaan internet bermasalah. Inconsistent discipline, poor monitoring/supervision dan corporal punishment merupakan variable yang dapat memprediksi peningkatan PIU siswa.Implikasi: Kajian ini berperan penting bagi instansi, guru, dan orang tua untuk menumbuhkan self-control sebagai upaya dalam menentukan pola asuh yang tepat kepada peserta didik ketika menggunakan internet.Orisinalitas: Penelitian ini merupakan kajian yang menitikberatkan pada permasalahan Problematic Internet Use (PIU) dan model pola asuh orang tua selama pandemi di Kota Malang.
Realisasi Multi Track Diplomacy pada Peran “1000 Abrahamic Circles Project” dalam Menciptakan Perdamaian antar Umat Beragama
Authors: Aini Rezki Putri Nur
Published: August 2022

This research aims to explain about how the realization of multi track diplomacy on the role of “1000 Abrahamic Circles Projects” as the main concept idea in creating ideals of peace between religious communities in the world. In order to create harmony between religious communities in the world, especially in the three Abrahamic religions (Islam, Christian, and Jews). It is necessary to have a concept idea as a bridge to uniting different views because of their diversity in beliefs. This phenomena become the moral responsibility of Indonesia as the largest Muslim majority country in the world to participate in achieving peace. According to Dino Pati Djalal as the founder of Foreign Policy of Community of Indonesia and the initiator of “1000 Abrahamic Circles Projects”, the tension and negativity between each of adherents the religion is higher. So, that we need a program that targeting the grassroots as a basic aspect of nature forming a change of thought in adherent overall. This diplomacy step taken by Dino represented individually through NGOs that Indonesia’s identity as a Muslim majority country which was quite tolerant in dealing with religious communities and concerned in the process of creating world peace by offering various strategies and diplomacy. In addition, as a Muslim, he initiated a form of diplomacy conducted by his NGOs as an arbitrator to overcome these problems. This paper will analyze one of the types of diplomacy realization carried out by a non-state actor and aims to create world peace, especially among the three religious communities with interesting ideas, “1000 Abrahamic Circles Projects” where in each circle will be facilitated by a trained interfaith dialogue facilitator and local guide so the process of improving relations is not just delivering speeches on certain stages, but should be begin by getting to know each other.
Indonesian Halal Food Industry: Development, Opportunities and Challenges on Halal Supply Chains
Authors: Peristiwo Hadi
Published: August 2022

This paper aims to determine the development, opportunities and challenges of the halal supply chain in the Indonesian halal food industry. The method used is descriptive qualitative method. A qualitative approach is a procedure that produces descriptive data in the form of written or spoken words from people and the observed behavior of giving a comprehensive picture. The type of research is descriptive with the aim that researchers can reveal facts, phenomena, and conditions present. Research results show in the era of the halal food chain and halal science as it is today, competition for halal food needs is higher than overseas, therefore halal food companies must maintain production, with the application and other technology companies must respond to consumers faster. The market potential for the halal food industry in Indonesia is developing rapidly. Over the past few years, Indonesia is ranked first as Halal food consumers in the world. Nevertheless, the market potential is very the amount has not been able to be used optimally by the government to improve Indonesia's economy. Maintaining the quality of halal food products is one way to compete with other countries in the halal food industry.
PEMBERIAN HAK ASUH ANAK DALAM PERCERAIAN KARENA PERALIHAN AGAMA (MURTAD)
Authors: Rofiq Muhammad Khoirur
Published: August 2022

Divorce due to apostasy causes child custody issues, is religion or the welfare of the child a priority? This study is a qualitative normative legal research with a juridical approach and a case approach. Primary data in this study are seven decisions of the Religious Courts regarding divorce by apostate parents and the determination of child custody. This paper focuses on examining (1) judges' considerations in determining custody of children in divorce due to apostasy, (2) patterns of granting custody of children in divorce due to apostasy. This research results in (1) The judge considers the conditions of the parties with three priority conditions for determining child custody, namely Islam, morals, and the ability to care for children. (2) the pattern of granting custody of children in divorce due to apostasy is (a) Islam becomes a priority requirement in determining child custody (b) if Islamic requirements are not met, then the moral requirements and the ability to care for the benefit of the child will be prioritized. The panel of judges will analyze the conditions of both parents to determine what is best for the child, even though custody is given to the apostate parent.
Modified Variational Iteration Method with Chebyshev Polynomials for Solving 12th order Boundary Value problems
Authors: Tsetimi Jonathan , K.O Ogeh , A. B Disu
Published: August 2022

We consider in this paper an illustration of the modified variational iteration method (MVIM) as an effective and accurate solver of 12th order boundary value problem (BVP). For this reason, the Chebyshev polynomials of the principal kind was utilized as a premise capabilities in the guess of the logical capability of the given issue. The strategy is applied in an immediate manner without utilizing linearization or irritation. The subsequent mathematical confirmations recommend that the strategy is without a doubt successful and exact as applied to a few direct and nonlinear issues as mathematical trial and error. Maple 18 was used for all computational simulations carried out in this research.©2022 JNSMR UIN Walisongo. All rights reserved.
The Paradox of Masculinity: The Narrative Identities among the Elderly in Yogyakarta
Authors: Drianus Oktarizal , Hayati Elli Nur
Published: August 2022

This study aimed to reveal both the narrative identities of elderly masculinity and the psychological dynamics that accompanied the journey of life as an older man. Five older men, who live in a geriatric house in Yogyakarta, were participated in this study. This study used hermeneutic-phenomenological approaches, with critical narrative analysis developed from Paul Ricoeur’s hermeneutics for the data analysis. The results showed that the face of elderly masculinity is paradoxical masculinity. At the ideal level, the older men appropriated hegemonic masculinity and were in the marginalized masculinity position at the level of reality. Masculine subjects had been experienced the maturation effect of togetherness with their wife. Wife has been an important subject as a medium for growth and a medium to maintain traditional manhood. Paradoxical condition and their intersection with the complexity of the psychological dynamics made older men offer a wiser masculine attitude and transform into positive masculinity values such as gratitude, acceptance of life, sincerity, and caring.
Artificial wetlands as a key for the construction of new sustainable urban systems
Authors: Albarracin Giovany , Contreras Christian , Puga Angel
Published: August 2022

Along the water route, man and nature interact intimately. The flow and occupation of the water route led to a relationship that emerged naturally within its logic. However, based on a deep understanding of complex and dynamic ecological processes, the relationship between man and natural processes has changed. Control and centralization buried these processes through a system of invisible infrastructures, causing a disconnection between the water path and the landscape's ecological processes. Providing clean water and an adequate sanitation system does not represent great complexity. While essential technologies and engineering principles have been mastered, it is striking that more than one billion people in the world still lack access to clean water, and almost two billion struggle with inadequate wastewater treatment. Furthermore, water-related diseases are the leading cause of premature death in developing countries. In searching for a solution to water sources and soil pollution, we propose exploring Artificial Wetlands (AW) as Nature-Based Solutions (NBS). These solutions provide environmental, social, and economic benefits. The research focuses on a hydraulic sanitation system disconnected from the central network. This system includes designing a system of artificial wetlands to treat wastewater produced by direct discharges to streams and rivers and proposes an AW in Sinincay (peripheral parish), where 42% of their territory does not have a wastewater treatment system. The results show that this phytoremediation technique is a passive and aesthetically pleasing cleaning practice that utilizes plants and solar energy to treat polluted waters. Thus, it is imperative to rethink sanitation concepts in order to integrate constructing infrastructures, ecological functions, and accessible spaces for people as a new alternative to a sustainable urban system.
Imitation and Traditions: Evaluation the effectiveness of ethnic identity culture on Architecture
Authors: Amer Mourad
Published: August 2022

This paper discusses the phenomenon of rapid urbanization and modernity that has omitted communities’ traditions. It evaluates the effectiveness of closing in on the sentience of ethics identity, it also presents solutions and instructions that create the balance between tradition and imitation, to conserve the history of our cities and social behaviors.
Changing academics’ ways of working: towards a distributed university campus
Authors: Migliore Alessandra , Tagliaro Chiara , Ciaramella Andrea
Published: August 2022

Academics are a peculiar category of knowledge workers whose work, by nature, is characterized by undefined time and space and includes individual and collaborative activities. Over the past decades, academics have progressively evolved their typically university-centric way of working towards a hybrid, spatially distributed model that includes home and other spaces. The spread of the Covid-19 pandemic has accelerated the redrawing of the geography of workspaces for academics and has opened up opportunities to enable creative, innovative and socially sustainable ways of working. Indeed, working from other spaces than the official workplace can not only have positive impacts on productivity, creativity, and collaboration of academics and staff, but also increase the attractiveness and inclusivity of university campuses by proposing a campus model that is spread across the territory according to the individual needs of its users.  While there are already some cases where university campuses accommodate coworking spaces, libraries and innovation hubs within them, evidence of academics using other spaces off-campus is scarce. This research investigates whether, and to what extent, the use of off-campus spaces by Italian academics is a likely and desirable prospect for the future, based on how much their way of doing research has evolved during the Covid-19 pandemic towards a multi-local way of working. A questionnaire was distributed among Italian tenured academics. This chapter presents a quantitative and qualitative interpretative analysis of the data collected from 1,199 answers to this questionnaire. Results describe different profiles of multi-local Italian academics, in relation to the types of location they work from, the experience they had during the Covid-working period and the future they wish for at university campuses. The evidence on multi-local work presented in this chapter shows implications both for academic staff and for university management. The former could approach work in a more distributed way such as it would extend university campuses to an urban and extra-urban dimension. The latter are called upon to meet the needs of their staff using socially sustainable ways of managing their facilities within and beyond campus boundaries.
A study on drinking water quality in different income groups of Vizianagaram region of India
Authors: Reddy M. Kiranmai , Priyadarshini N. Priyanka , Singh Visakha , Suresh Reddy K.V.N.
Published: August 2022

Portable clean water consumption is the basic right of every individual. The major global concern is water pollution which can cause mortality. Change in physicochemical characteristics in drinking water is not only a pollution problem, but the presence of antibiotic-resistant microbes is also a significant issue. The study was carried out to assess the physicochemical and microbiological quality of the reservoir, municipality-supplied water, and bottled water. A total of 100 samples were collected from different income classes (higher, medium, and low) groups. The experiments were carried out based on the guidelines of APHA. In the present study, 40% of samples have been found to be contaminated with bacteria such as Escherichia coli, Vibrio cholerae, and Enterobacter aerogenes. Moreover, these bacteria also showed antibiotic resistance to certain drugs. The percentage of isolated bacterial strains was resistant to amoxicillin and ampicillin antibiotics. The statistical analysis of the Chi-square test states that there is a significant correlation between E. coli and other microbes (p ≤ 0.5). This study gives a piece of baseline information about the prevalence of antibiotic-resistant bacteria and focuses on the improvement of water from purification before reaching the consumer.
Chemotherapy and Anticancer Drugs Adjustment in Obesity: A Narrative
Review
Authors: Thimotheo Batista João Pedro , Santos Marzano Lucas Alexandre , Menezes Silva Renata Aguiar , de Sá Rodrigues Karla Emília , Simões e Silva Ana Cristina
Published: August 2022

Background:

Obese individuals have higher rates of cancer incidence and cancer-
related mortality. The worse chemotherapy outcomes observed in this subset of patients
are multifactorial, including the altered physiology in obesity and its impact on
pharmacokinetics, the possible increased risk of underdosing, and treatment-related toxicity.

Aim:

The present review aimed to discuss recent data on physiology, providing just an
overall perspective and pharmacokinetic alterations in obesity concerning chemotherapy.
We also reviewed the controversies of dosing adjustment strategies in adult and pediatric
patients, mainly addressing the use of actual total body weight and ideal body weight.

Methods:

This narrative review tried to provide the best evidence to support antineoplastic
drug dosing strategies in children, adolescents, and adults.

Results:

Cardiovascular, hepatic, and renal alterations of obesity can affect the distribution,
metabolism, and clearance of drugs. Anticancer drugs have a narrow therapeutic
range, and variations in dosing may result in either toxicity or underdosing. Obese patients
are underrepresented in clinical trials that focus on determining recommendations
for chemotherapy dosing and administration in clinical practice. After considering associated
comorbidities, the guidelines recommend that chemotherapy should be dosed according
to body surface area (BSA) calculated with actual total body weight, not an estimate
or ideal weight, especially when the intention of therapy is the cure.

Conclusion:

The actual total body weight dosing appears to be a better approach to dosing
anticancer drugs in both adults and children when aiming for curative results, showing
no difference in toxicity and no limitation in treatment outcomes compared to adjusted
doses.
Present and Future Prospects of the Anti-cancer Activities of Saikosaponins
Authors: Jiao Zuo-Yi , Xiao Li-Xia , Zhou Hui-Nian
Published: August 2022

Since their discovery, saikosaponins (SSs) have been found to play an important role in
treating a variety of cancers via diverse mechanisms of action. This review summarizes the current research
status and prospects of the anti-cancer activities of SSs, providing novel insights into the limitations
of current studies. In addition, it discusses whether SSs can be applied in immunotherapy and
the possible mechanisms by which SSs may facilitate immunotherapy. The research is significant to
understanding the anti-cancer potents of SSs in the development of SSs-based therapeutic strategies
and clinical practice.
Protein Aggregation in Neurodegenerative Diseases
Authors: Chaudhary Rishabh , Rehman Mujeeba , Agarwal Vipul , Kaushik Arjun Singh , Mishra Vikas
Published: August 2022

Protein aggregation-related diseases primarily affect the central nervous
system and are involved in the pathogenesis of multiple neurodegenerative diseases as
well as several rare hereditary disorders that involve the deposition of protein
aggregates in the brain. These diseases include Alzheimer's, Parkinson, Huntington's
disease, Prion diseases, amyotrophic lateral sclerosis, familial amyloid polyneuropathy,
etc. The aggregates usually consist of fibers containing misfolded protein with a betasheet conformation. As a result, proteins’ secondary structures change from α-helix to
β-sheet, leading to the accumulation of harmful misfolded protein aggregates in the
CNS. The misfolding, subsequent aggregation and accumulation of proteins in
neurodegenerative diseases lead to cellular dysfunction, loss of synaptic connections
and brain damage. This chapter discusses some of the important neurodegenerative
diseases resulting from protein misfolding and explains the pathological mechanisms
behind brain damage.
Stress coping and its relation to psychological and social adjustment in female students at Majmaah University during COVID-19
Authors:   Kindergarten Department, Education Faculty, Majmaah University, Al Majma'ah, Saudi Arabia, Abdullehalim Maha Ahmed
Published: August 2022

This research aims to investigate the ability to cope with stress and the psychological and social adjustment level and to estimate the relationship between them and the semester rate. The research sample consisted of 106 female students who were chosen randomly. The research used a scale of coping with psychological stress that contained 20 phrases and the psychological and social adjustment scale that contained 21 phrases. The most important results were: The level of ability to cope with the stress due to the COVID-19 increased among kindergarten students at the Faculty of Education, Majmaah University. The results agreed with some studies in that the level of psychological and social adjustment increased after COVID-19. Also, there is a positive relationship between the ability to face stress and socio-psychological adjustment. There is no relationship between the ability to face stress due to COVID-19 and semester average, as it is not statistically significant.
Transformacja cyfrowa a kondycja ludzka. O relacjach międzyludzkich i matrycy transcendentnej
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Nowak Paweł ,   Uniwersytet im. Adama Mickiewicza w Poznaniu,   Universita di Trento (Włochy)
Published: August 2022

The aim of the article is to show the influence of digital transformation on the human condition. Based on desk research, the author addresses the issue of the relationship between new technologies and human existence in the context of relationality. Referring to the assumptions of symbolic interactionism, the author points out that relationships between people are constitutive value in human life. Digital transformation, whose overarching goal is the optimization of economic and social processes, introduces several changes in the models of interpersonal relations. These changes have a different effect, which the author presents by presenting various positions. There is also a foundation of humanity on the accounts, which Pierpaolo Donati describes as a transcendental matrix that cannot be replaced by technological solutions in any way. This conclusion implies a final reflection on the need to maintain a certain moderation in the field of technological transformations caused by digital transformation.
Edukacja skupiona na karierze, czyli o roli edukacji formalnej i pozaformalnej w przygotowaniu do życia zawodowego
Authors:   Akademia Pedagogiki Specjalnej w Warszawie, Tłuściak-Deliowska Aleksandra , Duda Ewa
Published: August 2022

The text is an overview, and its purpose is to analyze educational activities that are significant for the choices made by teenagers regarding their educational and professional path. The starting point for the undertaken analyzes is the assumption that education plays an important role in shaping the worldview of students, their behavior and career paths by providing various types of experiences. Analyzes of educational activities have been made considering the division into formal, non-formal and informal learning.
Odpowiedzialne rodzicielstwo – w etyczno-moralnym kontekście wolności i prawdy
Authors:   Uniwersytet Pedagogiczny im. Komisji Edukacji Narodowej w Krakowie, Adamczyk Dariusz
Published: August 2022

The article concerns the issue of responsible parenthood considered in the ethical and moral context of freedom and truth. The sense of responsibility is closely related to the truth about man and his freedom. It is about an objective truth read in conscience. The truth about human freedom conditions responsibility, which is God's response to His gift of vocation. The essence of responsible parenting is included in the combined approach to its individual aspects, which the properly understood religious aspect emerges, constituting a kind of a test of the correctness of reference to the others.
Dzieła sztuki – dokumenty średniowiecznej historii cysterskiego opactwa w Lądzie: patena Mieszka III, rozbudowa klasztoru do lat 60. XIV w. i „Oratorium św. Jakuba Apostoła”, kielich Kazimierza Wielkiego, stauroteka-pacyfikał
Authors:   Kustosz Zabytków Dawnego Opactwa w Lądzie, Nowiński Janusz
Published: August 2022

Important events in the medieval history of the Cistercian Abbey at Ląd: its refoundation in 1193, support of the policy of King Casimir the Great in Greater Poland in the fifties, and the expansion of the claustrum in the sixties of the 14th century, were documented with outstanding works of art funded by the Abbey benefactors. These works of art include: a chalice (not preserved) and a paten from the foundation of Prince Mieszko III (Fig. 1-4); Oratory of St. James the Apostle with a unique polychrome from the foundation of Wierzbięta from Palowice (Fig. 6-12); a silver and gilded chalice richly decorated with enamel - a gift of King Casimir the Great (Fig. 14); and a staurotec-ostulatory probably from the foundation of Archbishop Jarosław Bogoria Skotnicki (Fig. 15). The article presents these works in the light of the latest research related to them and provides the author's new interpretations and attribution hypotheses.
Selection of Heifers and Breeding Bulls for Reducing Calving Difficulties in the First Calvers: An Overview
Authors: Shah Nadeem , Sethi Manisha , Kumar Pratyush . , Mohanty Tushar K. , Bhakat Mukesh . , Dewry Raju K. , Sarkar Debajyoti . , Gupta Vinod K. , Soe Aye .
Published: August 2022

Calving difficulty is associated with cow mortality, calf loss, veterinary and labor costs, and causes delayed return to estrus and lower conception rate. Dystocia is common in heifers, and the frequency decreases with the increasing age of the cow. Farmers need to consider both genetics and management factors in an attempt to reduce dystocia. Calf birth weight, the pelvic area of the dam and their interrelationships are major determinants of dystocia. The weight of the calf is governed by genetic, environmental and management factors. Genetic factors include sex, length of gestation, breed, inbreeding, and genotype. Non-genetic factors include age and parity of the dam, nutrition of the dam during various phases of gestation, and environmental temperature and humidity. Dystocia management must begin with a selection of heifer for mating with respect to the body weight of heifers, body condition score (BCS) and dam’s pelvic area should be considered before heifer selection. Not only heifer selection but sire selection using an estimated breeding value for calving ease should also be considered to lessen the dystocia rate in a herd. A combination of culling heifers with small pelvic areas and using bulls reported to be calving ease sire may reduce dystocia significantly. Apart from all these factors, genomic selection for reducing calving difficulties is a new tool for dystocia management.
Molecular Detection of Antimicrobial Resistant genes with special reference to ESBL in E. coli from Diarrheic Piglets
Authors: Grakh Kushal . , Mittal Dinesh . , Prakash Anand . , Moudgil Pallavi . , Kumar Pankaj . , Kumar Ramesh .
Published: August 2022

Antimicrobial resistance (AMR) has been identified as a global threat. E. coli is known to carry different AMR genes and responsible for huge economic loss owing to AMR. In the present study 14 previously confirmed E. coli isolates associated with piglet diarrhea were analyzed for pathogenicity and hemolysin production traits, molecular detection of AMR genes, screening for extended-spectrum andBeta;-lactamases (ESBLs) by phenotypic and molecular methods. These isolates were previously identified as E. coli by Vitek 2 Compact system and revealed antimicrobial resistance using the disc diffusion method. After re-confirmation using PCR amplification of uspA (universal stress protein) gene, these isolates were characterized for pathogenic traits. AMR genes for penicillins, cephalosporins, tetracyclines, and sulfonamide drugs were probed in 14 isolates. Phenotypic ESBL detection method revealed 5/14 (37.5%) of the isolates as ESBL positive. Molecular methods using ESBL genes found 6/14 (42.8%) isolates as ESBL positive. We also investigated the presence of sulfa and tetracyclines AMR genes in these isolates. Out of 14 isolates, the sul2 gene in five isolates, sul1 gene in seven isolates and tetB gene in two isolates, was detected out of 14 isolates. None of the isolates were found to carry tetA, tetM, and dfrA1 genes. The present study finds swine E. coli isolates carrying blaTEM, blaSHV, and blaCTX-M genes along with other antimicrobial resistance genes viz., sul1, sul2, and tetB. Thus, this study suggests further surveillance for the detection of resistance genes among E. coli isolates of swine-origin as these genes can be transferred to human E. coli isolates.
Transdiagnostic Internet-Delivered Cognitive Behavioral Therapy for Symptoms of Postpartum Anxiety and Depression: Feasibility Randomized Controlled Trial
Authors: Suchan Victoria , Peynenburg Vanessa , Thiessen David , Nugent Marcie , Dear Blake , Titov Nickolai , Hadjistavropoulos Heather
Published: August 2022

Background

Postpartum depression (PPD) and postpartum anxiety (PPA) are often comorbid and are associated with significant personal and economic costs. Fewer than half of the mothers experiencing PPD or PPA symptoms receive face-to-face treatment, suggesting a need for alternative delivery formats such as internet-delivered cognitive behavioral therapy (ICBT).

Objective

This pilot study aimed to examine the impact of a therapist-assisted, transdiagnostic ICBT program on symptoms of PPD and PPA, as there is only one previous study on transdiagnostic ICBT with this population, which did not include therapist assistance.

Methods

Clients endorsing the symptoms of PPD or PPA (N=63) were randomized to an 8-week transdiagnostic ICBT course (Wellbeing Course for New Moms) or to treatment as usual (TAU). Clients completed measures of depression, anxiety, stress, postnatal bonding, and relationship satisfaction, as well as measures of treatment satisfaction and therapeutic alliance, before treatment, after treatment, and at the 1-month follow-up. Outcome measures were also completed at the 6-month follow-up for clients who completed the ICBT course.

Results

Both the ICBT and TAU groups experienced statistically significant improvements over time. The ICBT group experienced larger improvements after treatment and at the 1-month follow-up on more measures than the TAU group, with medium between-group Cohen d effects on primary outcome measures for anxiety (Cohen d=0.65, 95% CI 0.13-1.17), PPD (Cohen d=0.52, 95% CI 0.01-1.04), and depression (Cohen d=0.56, 95% CI 0.05-1.08), and on secondary outcome measures of overall distress (Cohen d=0.69, 95% CI 0.17-1.21), anxiety (Cohen d=0.59, 95% CI 0.07-1.11), and stress (Cohen d=0.76, 95% CI 0.23-1.28). Time-by-group interactions for proportional reductions between groups over time were only significant after treatment and at the 1-month follow-up for the primary anxiety measure (P=.006). This study was underpowered for detecting small or medium effects. Overall, clients perceived the treatment as credible, and 95% (21/22) of the clients were satisfied with the treatment content and therapist support.

Conclusions

Findings from this pilot study provide preliminary support for transdiagnostic ICBT in treating PPD and PPA symptoms to improve access to psychological treatments.

Trial Registration

ClinicalTrials.gov NCT04012580; https://clinicaltrials.gov/ct2/show/NCT04012580
A REVIEW ON MULTIPURPOSE MEDICINAL PROPERTIES OF TRADITIONALLY USED PSIDIUM GUAJAVA LEAVES
Authors: AHAMAD ADIL , ANSARI S H
Published: August 2022

Psidium guajava is an important food crop and medicinal plant available in tropical and subtropical countries. P. guajava (Guava), belonging to the family of Myrtaceae. P. guajava Linn. (Guava) is used not only as food but also as folk medicine in subtropical areas around the world because of its pharmacologic activities. It contains important phytoconstituents such as tannins, triterpenes, flavonoid, quercetin, pentacyclic triterpenoid, guajanoic acid, saponins, carotenoids, lectins, leucocyanidin, ellagic acid, amritoside, beta-sitosterol, uvaol, oleanolic acid, and ursolic acid. Conventionally, guava is used for the treatment of various ailments such as antioxidant, hepatoprotective, anti-allergy, antimicrobial, antigenotoxic, antiplasmodial, cytotoxic, antispasmodic, cardioactive, anti-cough, antidiabetic, anti-inflammatory, and antinociceptive activities, supporting its traditional uses.