bluuebunny/crossref_metadata_2025 huggingface dataset:
The pH and Sucrose Influence Rhamnolipid Action Toward Planktonic and Biofilms of Listeria monocytogenes
Authors: Passos Tathiane Ferroni , Nitschke Marcia
Published: October 2024

Bacterial resistance and persistence in food environments are major concerns for the industry, which constantly seeks new strategies to reduce microbial contamination. Rhamnolipids (RL) biosurfactants are considered sustainable and green alternatives to synthetics; furthermore, they have demonstrated potential for controlling various foodborne pathogens. Food environments are typically exposed to diverse pH, solutes, temperatures, and water activity (aw) levels that may favor the survival of pathogens. Therefore, it is crucial to consider these factors in evaluating the performance of novel antimicrobials. Our study examined the influence of pH and sucrose on the antimicrobial activity of RL against both planktonic and biofilm of Listeria monocytogenes. We found that the presence of sucrose can enhance the antimicrobial effectiveness of RL against both planktonic and sessile bacteria. The addition of sugar particularly improved RL action at pH 6 and 7. Moreover, we observed that the type and size of RL self-assembly structures depend on the pH and sucrose concentration. These findings suggest potential for developing RL-based innovative methods to control L. monocytogenes in sugar-rich or -low aw foods and environments.
The Effects of swnH1 Gene Function of Endophytic Fungus Alternaria oxytropis OW 7.8 on Its Swainsonine Biosynthesis
Authors: Li Dan , Zhao Xinlei , Lu Ping , Min Yu
Published: October 2024

The swnH1 gene in the endophytic fungus Alternaria oxytropis OW 7.8 isolated from Oxytropis glabra was identified, and the gene knockout mutant ΔswnH1 was first constructed in this study. Compared with A. oxytropis OW 7.8, the ΔswnH1 mutant exhibited altered colony and mycelium morphology, slower growth rate, and no swainsonine (SW) in mycelia, indicating that the function of the swnH1 gene promoted SW biosynthesis. Five differential expressed genes (DEGs) closely associated with SW synthesis were identified by transcriptomic analysis of A. oxytropis OW 7.8 and ΔswnH1, with sac, swnR, swnK, swnN, and swnH2 down-regulating. Six differential metabolites (DEMs) closely associated with SW synthesis were identified by metabolomic analysis, with P450, PKS-NRPS, saccharopine, lipopolysaccharide kinase, L-PA, α-aminoadipic, and L-stachydrine down-regulated, while L-proline was up-regulated. The SW biosynthetic pathways in A. oxytropis OW 7.8 were predicted and refined. The results lay the foundation for in-depth exploration of the molecular mechanisms and metabolic pathways of SW synthesis in fungi and provide reference for future control of SW in locoweeds, which would benefit the development of animal husbandry and the sustainable use of grassland ecosystems.
Hypogene Alteration of Base–Metal Mineralization at the Václav Vein (Březové Hory Deposit, Příbram, Czech Republic): The Result of Recurrent Infiltration of Oxidized Fluids
Authors: Dolníček Zdeněk , Sejkora Jiří , Škácha Pavel
Published: October 2024

The Václav vein (Březové Hory deposit, Příbram ore area, Czech Republic) is a base–metal vein containing minor Cu-Zn-Pb-Ag-Sb sulfidic mineralization in a usually hematitized gangue. A detailed mineralogical study using an electron microprobe revealed a complicated multistage evolution of the vein. Early siderite and Fe-rich dolomite were strongly replaced by assemblages of hematite+rhodochrosite and hematite+kutnohorite/Mn-rich dolomite, respectively. In addition, siderite also experienced strong silicification. These changes were associated with the dissolution of associated sulfides (sphalerite, galena). The following portion of the vein contains low-Mn dolomite and calcite gangue with Zn-rich chlorite, wittichenite, tetrahedrite-group minerals, chalcopyrite, bornite, and djurleite, again showing common replacement textures in case of sulfides. The latest stage was characterized by the input of Ag and Hg, giving rise to Ag-Cu sulfides, native silver (partly Hg-rich), balkanite, and (meta)cinnabar. We explain the formation of hematite-bearing oxidized assemblages at the expense of pre-existing “normal” Příbram mineralization due to repeated episodic infiltration of oxygenated surface waters during the vein evolution. Episodic mixing of ore fluids with surface waters was suggested from previous stable isotope and fluid inclusion studies in the Příbram ore area. Our mineralogical study thus strengthens this genetic scenario, illustrates the dynamics of fluid movement during the evolution of a distinct ore vein structure, and shows that the low content of ore minerals cannot be necessarily a primary feature of a vein.
Prospect for Fine and Coarse Coal Waste Deployment for a Constructed Technosol and Eragrostis Tef Growth
Authors: de Oliveira Eduardo Kercher , Venturella Arthur Cesa , Weiler Jéssica , Schneider Ivo André Homrich
Published: October 2024

The aim of this study was to evaluate soil properties and Eragrostis tef (teff) growth on Technosols produced from coarse and fine coal wastes from Moatize Mine, Mozambique. The experiment was performed in triplicate in 30 L containers filled with different substrate conditions, composed of fine coal waste, coarse coal waste, agricultural soil, and sewage sludge as an organic matter source. The soil analyses included bulk density, available water capacity, permeability, and fertility. Plant growth was monitored for biomass production and plant tissue composition. All the substrates presented a good available water capacity and a proper drainage condition. Regarding soil fertility, there were shortages of potassium and boron in the substrates composed exclusively of coal wastes, which was reflected in the composition of the plant tissue. Even so, plant growth was statistically equivalent to the control in all conditions, except for the substrate produced exclusively with fine coal waste and sewage sludge, which presented a better performance. Technosols are an alternative for reducing the final mine waste volume, and Eragrostis tef is used as a means for land use after the mining process, with social gains, and as a tool in an ecological process for restoring coal mining sites.
Hydrogenation Versus Hydrosilylation: The Substantial Impact of a Palladium Capsule on the Catalytic Outcome
Authors: Steinmetz Maxime , Schurhammer Rachel , Gourlaouen Christophe , Sémeril David
Published: October 2024

A palladium capsule, made of three cavitands, namely P,P-dichlorido{5,17-bis[5-(diphenylphosphanyl)-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arenyl-17-oxymthyl]-4(24),6(10),12(16),18(22)-tetramethylenedioxy-2,8,14,20-tetrapentylresorcin[4]arene}palladium(II) (1), was synthetized by coordination of the corresponding diphosphinated ligand and the palladium precursor [PdCl2(PhCN)2] in 27% yield. The obtained P,P-chelate complex was fully characterized by elemental analysis, NMR and mass spectrometry. Molecular dynamics simulations carried out on the metallo-capsule showed the structure made by the three cavitands was slightly distorted over the 1 μs of the simulation. The evaluation of the palladium capsule 1 in the reaction between arylacetylenes and Et3SiH in undried conditions unequivocally demonstrates a drastic change in chemoselectivity, with the formation of the partially hydrogenation product rather than the hydrosilylation products observed with complexes whose active center is more accessible, for instance [PdCl2(PPh3)2].
Molecular Networking, Docking, and Biological Evaluation of Licarin A from Myristica fragrans as a Potential Cancer Chemopreventive Agent
Authors: Blanco Carcache Peter J. , Castro-Dionicio Ines Y. , Mirtallo Ezzone Nathan P. , Salinas-Arrellano Eric D. , Bahar Joshua , Clinton Steven K. , Kinghorn A. Douglas
Published: October 2024

Currently, clinically available cancer chemopreventive drug options are limited to mostly tamoxifen and its derivatives, such as raloxifene, and approved specifically for breast cancer. Thus, the availability of chemopreventive drug molecules for other types of malignant cancers would be desirable. In previous reports, the arils of Myristica fragrans (mace) have been found to exhibit cancer chemopreventive activity. Therefore, the purpose of the present study was to identify a natural product from this species with potential chemopreventive activity guided by chemoinformatic sample analysis via Global Natural Products Social (GNPS) molecular networking and molecular docking. The neolignan licarin A (1) was identified as a potential chemopreventive constituent, and subsequently submitted to several in vitro bioassays and a zebrafish toxicity evaluation. In this work, 1 afforded superior phosphoNF-κBp65 phosphorylation activity in DU-145 prostate cancer cells compared to isoliquiritigenin (2), which was used as a natural product chemopreventive control. Both 1 and 2 showed a longer-lasting reduction in cellular stress in a cell oxidative stress real-time dose–response assay than the positive control using Hepa1c1c7 mouse hepatoma cells. In addition, 1 displayed similar activities to 2, while also being less toxic to zebrafish (Danio rerio) than both this chalcone and the clinically used chemopreventive drug tamoxifen.
Facile Synthesis of Low-Dimensional and Mild-Alkaline Magnesium Carbonate Hydrate for Safe Multiple Protection of Paper Relics
Authors: Wang Yi , Zhu Zirui , Wang Jinhua , Liu Peng , Ji Xingxiang , Zhang Hongbin , Tang Yi
Published: October 2024

Paper-based cultural relics inevitably face a variety of diseases such as acidification, yellowing, and strength loss during long-term preservation, where weakly alkaline inorganic materials play an important role in their deacidification treatments. In this work, by simply adjusting the supersaturation of crystal growing solution without the use of any organic additives, one-dimensional (1D) and two-dimensional (2D) weakly alkaline materials—magnesium carbonate hydrates (MCHs)—were controllably synthesized. It is worth noting that the coatings of 1D/2D MCHs not only cause little change in chromatic aberration and water wettability, but also ensure their safety for alkali-sensitive pigments. Meanwhile, the deacidification, anti-aging, strength-enhancing, and flame-retardant effects of these materials have been tested on ancient book papers, all of which achieved good protective effects. In contrast, 1D MCH materials brought about significant enhancement in both mechanical strengths and flame-retardant effects, and the related effects were investigated. Based on this facile micromorphology control strategy, more low-dimensional nanomaterials are expected to be synthesized by design for the protection of paper-based relics, which will expand our knowledge on functional deacidification and protection mechanisms.
Detoxification of Acrylamide by Potentially Probiotic Strains of Lactic Acid Bacteria and Yeast
Authors: Maher Agnieszka , Miśkiewicz Karolina , Rosicka-Kaczmarek Justyna , Nowak Adriana
Published: October 2024

Some potentially probiotic strains of lactic acid bacteria (LAB) and yeast that inhabit the digestive tract of humans are known to detoxify xenobiotics, including acrylamide (AA). The objective of the subsequent research was to evaluate the AA-detoxification capability of LAB and yeast isolated from various sources. Namely, the effect of AA was tested on the growth of LAB and yeast strains, as well in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Subsequently, the AA-binding ability of LAB and yeast was investigated in various environments, including the pH, incubation temperature, cell density, and with inanimate cells. The ability of selected LAB and yeast to reduce the genotoxicity of AA was tested on Caco-2 and Hep-G2 cell lines. The results showed that all tested strains exhibited strong resistance to AA at concentrations of 5, 10, and 50 µg/mL. Also, AA was detected in the intracellular and membrane extracts of tested strains. The most effective binding strain was Pediococcus acidilactici 16 at pH = 5, cell density = 109 CFU/mL, and incubation temperature = 37 °C (87.6% of AA removed). Additionally, all tested strains reduced the genotoxicity of AA, with the greatest reduction observed at the highest concentration of 50 µg/mL. The phenomena of detoxification by potentially probiotic strains could reduce the toxic and harmful effects of AA exposure to humans every day.
Cannabinoids—Multifunctional Compounds, Applications and Challenges—Mini Review
Authors: Duczmal Dominik , Bazan-Wozniak Aleksandra , Niedzielska Krystyna , Pietrzak Robert
Published: October 2024

Cannabinoids represent a highly researched group of plant-derived ingredients. The substantial investment of funds from state and commercial sources has facilitated a significant increase in knowledge about these ingredients. Cannabinoids can be classified into three principal categories: plant-derived phytocannabinoids, synthetic cannabinoids and endogenous cannabinoids, along with the enzymes responsible for their synthesis and degradation. All of these compounds interact biologically with type 1 (CB1) and/or type 2 (CB2) cannabinoid receptors. A substantial body of evidence from in vitro and in vivo studies has demonstrated that cannabinoids and inhibitors of endocannabinoid degradation possess anti-inflammatory, antioxidant, antitumour and antifibrotic properties with beneficial effects. This review, which spans the period from 1940 to 2024, offers an overview of the potential therapeutic applications of natural and synthetic cannabinoids. The development of these substances is essential for the global market of do-it-yourself drugs to fully exploit the promising therapeutic properties of cannabinoids.
Peptide-Conjugated Vascular Endothelial Extracellular Vesicles Encapsulating Vinorelbine for Lung Cancer Targeted Therapeutics
Authors: Gaurav Isha , Thakur Abhimanyu , Zhang Kui , Thakur Sudha , Hu Xin , Xu Zhijie , Kumar Gaurav , Jaganathan Ravindran , Iyaswamy Ashok , Li Min , Zhang Ge , Yang Zhijun
Published: October 2024

Lung cancer is one of the major cancer types and poses challenges in its treatment, including lack of specificity and harm to healthy cells. Nanoparticle-based drug delivery systems (NDDSs) show promise in overcoming these challenges. While conventional NDDSs have drawbacks, such as immune response and capture by the reticuloendothelial system (RES), extracellular vesicles (EVs) present a potential solution. EVs, which are naturally released from cells, can evade the RES without surface modification and with minimal toxicity to healthy cells. This makes them a promising candidate for developing a lung-cancer-targeting drug delivery system. EVs isolated from vascular endothelial cells, such as human umbilical endothelial-cell-derived EVs (HUVEC-EVs), have shown anti-angiogenic activity in a lung cancer mouse model; therefore, in this study, HUVEC-EVs were chosen as a carrier for drug delivery. To achieve lung-cancer-specific targeting, HUVEC-EVs were engineered to be decorated with GE11 peptides (GE11-HUVEC-EVs) via a postinsertional technique to target the epidermal growth factor receptor (EGFR) that is overexpressed on the surface of lung cancer cells. The GE11-HUVEC-EVs were loaded with vinorelbine (GE11-HUVEC-EVs-Vin), and then characterized and evaluated in in vitro and in vivo lung cancer models. Further, we examined the binding affinity of ABCB1, encoding P-glycoprotein, which plays a crucial role in chemoresistance via the efflux of the drug. Our results indicate that GE11-HUVEC-EVs-Vin effectively showed tumoricidal effects against cell and mouse models of lung cancer.
Description and Classification of Tempering Materials Present in Pottery Using Digital X-Radiography
Authors: Nagaya Alan , de Lucio Oscar G. , Ortiz Ruiz Soledad , Uc González Eunice , Peraza Lope Carlos , Cruz Alvarado Wilberth
Published: October 2024

Archaeological pottery X-radiography is mainly used for two applications: fabric characterization and identification of forming techniques. Both applications require imaging of tempering materials and other additives. With digital X-radiography, it is easy to enhance the image to compute and characterize these materials. In this study, a combination of ImageJ plug-ins such as “threshold”, “analyze particles”, and “fit polynomial” were used to describe tempering materials of a set composed of archaeological pottery sherds. It was found that two different types of tempering materials were used. The first type was characterized by a grain size of less than 0.5 mm and no well-formed particles. In contrast, the second group had a grain size larger than 0.5 mm and well-formed particles.
Harnessing Mitophagy for Therapeutic Advances in Aging and Chronic Neurodegenerative Diseases
Authors: Ghosh Devlina , Kumar Alok
Published: October 2024

Introduction: Mitophagy, the selective degradation of damaged mitochondria, is essential for maintaining cellular health and function, particularly in high-energy demanding post-mitotic cells like neurons and in microglial cells. Aging results in impaired mitophagy, leading to mitochondrial dysfunction, oxidative stress, the release of damage-associated proteins (DAMPs), and neuroinflammation, which contribute to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Mitochondrial dysfunction also contributes to the pathophysiology of depression by affecting synaptic plasticity, increasing neuroinflammation, and heightening oxidative stress. Aim: In this review, we summarize the recent developments on mechanisms of mitophagy, its therapeutic role in neuroprotection, and its implications in aging and neuroinflammation, complemented by future research requirements and implications. Result/Discussion: Therapeutic strategies that promote mitochondrial health, including enhancing mitophagy and mitochondrial biogenesis, show promise in treating neurodegenerative diseases and depression. Recent findings have emphasized therapeutic strategies to modulate mitophagy, such as pharmacological agents like urolithin A and rapamycin, genetic interventions such as PINK1/Parkin gene therapy, mitochondrial transplantation, and lifestyle and dietary interventions such as caloric restriction, exercise, and dietary supplements such as resveratrol and CoQ10. Key regulators of mitophagy, including the PINK1/Parkin pathway and various proteins like BNIP3, NIX, and FUNDC1, which facilitate the removal of damaged mitochondria, play a crucial role. Conclusions: These results highlight the importance of understanding the interplay between mitophagy and neuroinflammation and show that modulation of mitophagy can reduce oxidative stress and improve neuroinflammatory outcomes and depression in age-related neurodegenerative diseases. However, despite significant progress, challenges remain in understanding the underlying molecular mechanisms of mitophagy and its therapeutic regulation in aging disorders.
Syndrome Sinistre: Left Brachiocephalic Vein Compression and its Neurological Manifestations
Authors: Arcot Karthikeyan M. , DeOrchis Vincent S.
Published: October 2024

Embryologically, the left brachiocephalic vein (LBV) originates as an anastomotic channel between the right and left anterior cardinal veins. This positions the LBV between the manubrium sterni anteriorly and the innominate artery posteriorly. This pattern of adjacency of the aorta to the LBV is unique to mammals and results from a quirk of evolution. With age, the ascending aorta unfolds, elongates and dilates. Simultaneously, there is a change in the thoracic geometry that reduces the thoracic volume primarily from disc height loss and kyphosis. These transitions progressively compress the LBV. Normally, this compression is circumvented via collateral pathways and “Blood finds a way”. However, traversing these circuitous pathways comes at a cost and can result in delayed transit times and venous congestion. While it is possible that compression of the LBV in the setting of adequate collateral channels may fail to provoke any pathologic sequelae, we propose a phenomenon in which such compression in the setting of inadequate collateral circulation may lead to a state of pathologic venous congestion. This anatomic anomaly and its associated clinical features, if identified, can offer a new avenue for treatment options for some of the hitherto unexplained neurologic disorders.
Initial Study on the Impact of Probiotics on Postoperative Gastrointestinal Symptoms and Gut Microbiota after Sleeve Gastrectomy: A Placebo-Controlled Study
Authors: Dowgiałło-Gornowicz Natalia , Mysiorska Dominika , Sosnowska-Turek Ewelina , Botulińska Anna , Lech Paweł
Published: October 2024

Background: Sleeve gastrectomy (SG) has become the predominant bariatric surgery, leading to significant weight loss and reductions in obesity-related complications. However, postoperative gastrointestinal symptoms such as constipation and bloating are common. This study aims to evaluate the impact of probiotic supplementation on postoperative gastrointestinal symptoms in patients undergoing SG. The secondary aim is to analyze laboratory and stool test results. Materials and methods: This prospective, placebo-controlled study included patients undergoing SG at a single center. Participants were adults without specific gastrointestinal diseases. They were randomly assigned to either the Probiotics or Controls group. Gastrointestinal symptoms and laboratory and stool tests were assessed before surgery and one month after. Results: Thirty-one patients participated, with 15 in the Probiotics group and 16 in the Controls group. Probiotic supplementation significantly increased the number of stools per week (p = 0.027) and reduced constipation incidence (p = 0.002). Patients in the Probiotics group reported easier defecation and greater bowel movement completeness (p = 0.015, p = 0.004). No significant differences in weight loss or laboratory tests were observed between the groups. Stool microbiota analysis showed a return to normal levels of Enterococcus faecalis, Enterococcus faecium, and Clostridium perfringens in the Probiotics group and an increase in the Controls group. Conclusions: Probiotic supplementation after SG significantly reduces constipation without adverse effects. These findings suggest that incorporating probiotics into postoperative care protocols can enhance patient comfort and recovery.
Associations Between Body Image, Eating Behaviors, and Diet Quality Among Young Women in New Zealand: The Role of Social Media
Authors: Malloy Jessica A. , Kazenbroot-Phillips Hugo , Roy Rajshri
Published: October 2024

Background/Objectives: This study investigates the relationship between diet quality and body image disturbance among young women aged 18–24, a crucial period for establishing lifelong health behaviors. Given the increasing exposure to social media, which often promotes unrealistic beauty standards, this research aims to explore associations between eating behaviors, diet quality, and body image disturbance. Methods: A mixed-methods approach was employed, combining qualitative focus group discussions with quantitative analysis. Focus groups (n = 19) explored themes of body image dissatisfaction. The Body Image Disturbance Questionnaire (BIDQ) was administered to 50 participants (young women aged 18–24) to quantitatively assess body image disturbance, while diet quality was evaluated using the Australian Recommended Food Scores (ARFS). The Three-Factor Eating Questionnaire (TFEQ-R18) was also used to assess eating behaviors, including cognitive restraint, uncontrolled eating, and emotional eating. A social influence questionnaire (SIQ) was administered to measure the effect of social influence. Pearson’s correlation coefficient was used to determine the relationship between ARFS, BIDQ, and TFEQ-R18 scores. Results: Qualitative findings revealed persistent dissatisfaction with body shape, largely influenced by social media. Quantitatively, 65% of participants scored above the clinical threshold for body image disturbance (mean BIDQ score = 4.2, SD = 0.8). The correlation between ARFS and BIDQ scores was weak and not statistically significant (r = 0.057, p = 0.711). However, a significant positive correlation was observed between time spent on social media and body image disturbance (r = 0.58, p < 0.01). Additionally, TFEQ-R18 results indicated that 45% of participants displayed moderate levels of uncontrolled eating, and 36.5% demonstrated moderate levels of emotional eating. Conclusions: While social media is associated with body image concerns, its effect on eating behaviors and diet quality shows weak correlations, suggesting that other factors may mediate these outcomes. These results suggest the complexity of the associations between body image, eating behaviors, and diet quality, indicating that interventions should consider psychological drivers behind these concerns alongside social media usage.
Human Breast Milk Exosomes: Affecting Factors, Their Possible Health Outcomes, and Future Directions in Dietetics
Authors: Çelik Elif , Cemali Özge , Şahin Teslime Özge , Deveci Gülsüm , Biçer Nihan Çakır , Hirfanoğlu İbrahim Murat , Ağagündüz Duygu , Budán Ferenc
Published: October 2024

Background: Human breast milk is a complex biological fluid containing multifaceted biological compounds that boost immune and metabolic system development that support the short- and long-term health of newborns. Recent literature suggests that human breast milk is a substantial source of nutrients, bioactive molecules, and exosomes. Objectives: This review examines the factors influencing exosomes noted in human milk and the impacts of exosomes on infant health. Furthermore, it discusses potential future prospects for exosome research in dietetics. Methods: Through a narrative review of the existing literature, we focused on exosomes in breast milk, exosome components and their potential impact on exosome health. Results: Exosomes are single-membrane extracellular vesicles of endosomal origin, with an approximate radius of 20–200 nm. They are natural messengers that cells secrete to transport a wide range of diverse cargoes, including deoxyribonucleic acid, ribonucleic acid, proteins, and lipids between various cells. Some studies have reported that the components noted in exosomes in human breast milk could be transferred to the infant and cause epigenetic changes. Thus, it can affect gene expression and cellular event regulation in several tissues. Conclusions: In this manner, exosomes are associated with several pathways, including the immune system, oxidative stress, and cell cycle, and they can affect the short- and long-term health of infants. However, there is still much to learn about the functions, effectiveness, and certain impacts on the health of human breast milk exosomes.
Unveiling the Power of Flax Lignans: From Plant Biosynthesis to Human Health Benefits
Authors: Gao Zhan , Cao Qinglei , Deng Zhongyuan
Published: October 2024

Background: Flax (Linum usitatissimum L.) is the richest plant source of lignin secondary metabolites. Lignans from flax have been applied in the fields of food, medicine, and health due to their significant physiological activities. The most abundant lignan is secoisolariciresinol, which exists in a glycosylated form in plants. Results: After ingestion, it is converted by human intestinal flora into enterodiol and enterolactone, which both have physiological roles. Here, the basic structures, contents, synthesis, regulatory, and metabolic pathways, as well as extraction and isolation methods, of flax lignans were reviewed. Additionally, the physiological activity-related mechanisms and their impacts on human health, from the biosynthesis of lignans in plants to the physiological activity effects observed in animal metabolites, were examined. Conclusions: The review elucidates that lignans, as phenolic compounds, not only function as active substances in plants but also offer significant nutritional values and health benefits when flax is consumed.
Positive Nursing Practice Environment: A Concept Analysis
Authors: Pereira Soraia , Ribeiro Marlene , Mendes Mariana , Ferreira Rosilene , Santos Eduardo , Fassarella Cintia , Ribeiro Olga
Published: October 2024

Background/Objectives: In recent years, research has increasingly highlighted the significance of nursing practice environments, linking positive settings with enhanced job satisfaction, professional autonomy, and care quality. Such environments can decrease turnover, stress, and costs while improving patient safety. Despite this extensive literature, there is limited consensus on defining a ‘positive nursing practice environment’, highlighting the need for a systematic analysis to advance understanding and application. This study aims to explore and clarify the concept of a ‘Positive Nursing Practice Environment’. Methods: This study applied Walker and Avant’s approach for concept analysis, conducting a comprehensive database search to gather relevant evidence. To review the available evidence on the concept of nursing practice environments, we followed the methodology proposed by JBI for scoping reviews. Results: The inclusion of 166 studies meeting the criteria provided a broad understanding of the topic, revealing 10 key attributes of a ‘positive nursing practice environment’ and identifying various antecedents and consequences affecting clients, nurses, and institutions. Conclusions: The concept analysis of a ‘Positive Nursing Practice Environment’ offers valuable insights into nurses’ working conditions, systematically identifying characteristics that impact professionals, patients, and institutions. This analysis lays the groundwork for future research and practical improvements in nursing practice environments. This study was not registered.
Influence of Dolphin-Watching Tourism Vessels on the Whistle Emission Pattern of Common Dolphins and Bottlenose Dolphins
Authors: Silva Ana A. , Castro Joana , Cid André , Jesus Sérgio M. , Matos Fábio L.
Published: October 2024

Recent years have seen a notable rise in dolphin-watching boat activities along the Algarve coast in Portugal, potentially affecting the common dolphin (Delphinus delphis) and bottlenose dolphin (Tursiops truncatus) local populations. This study examines the impact of increasing underwater noise levels from these boats on dolphin vocalizations. Field recordings were conducted from June to September 2022, analyzing dolphin whistles in various boat presence scenarios. The results indicate significant changes in whistle-frequency characteristics with boat presence, including increased start, low, and high frequencies, alongside a decrease in the number of inflection points in modulated whistles. The changes might negatively impact dolphin populations viability, underscoring the need for further research. Additionally, improved mitigation strategies may be necessary to reduce the potential negative effects of dolphin watching on cetacean communication and behavior in the Algarve region.
Synthesis of Isoxazol-5-One Derivatives Catalyzed by Amine-Functionalized Cellulose
Authors: Gharehassanlou Sanaz , Kiyani Hamzeh
Published: October 2024

In this contribution, propylamine-functionalized cellulose (Cell-Pr-NH2) was employed as the catalyst in the three-component reaction between hydroxylamine hydrochloride and various types of aryl/heteroaryl aldehydes, ethyl acetoacetate/ethyl 4-chloroacetoacetate, or ethyl 3-oxohexanoate. The result of these experiments was the formation of 3,4-disubstituted isoxazol-5(4H)-one heterocycles. The desired five-membered heterocyclic compounds were obtained in good to high yields at room temperature. The investigation of different solvents led us to the conclusion that water is the best solvent to perform the current one-pot, three-component reactions. Attempts to find the optimal catalyst loading clearly showed that 14 mg of cell-Pr-NH2 seems to be sufficient to carry out the reactions. This method has highlighted some principles of green chemistry including less waste generation, atom economy, use of water as an environmentally friendly solvent, and energy saving. Purification without chromatographic methods, mild reaction conditions, simple work-up, low-cost reaction medium, saving time, and obtainable precursors are other notable features of this one-pot fashion.
Hurst Exponent and Event-by-Event Fluctuations in Relativistic Nucleus–Nucleus Collisions
Authors: Fedosimova Anastasiya I. , Olimov Khusniddin K. , Lebedev Igor A. , Ibraimova Sayora A. , Bondar Ekaterina A. , Dmitriyeva Elena A. , Mukanov Ernazar B.
Published: October 2024

A joint study of multi-particle pseudo-rapidity correlations and event-by-event fluctuations in the distributions of secondary particles and fragments of the target nucleus and the projectile nucleus was carried out in order to search for correlated clusters of secondary particles. An analysis of the collisions of the sulfur nucleus with photoemulsion nuclei at an energy of 200 A·GeV is presented based on experimental data obtained at the SPS at CERN. The analysis of multi-particle correlations was performed using the Hurst method. A detailed analysis of each individual event showed that in events of complete destruction of a projectile nucleus with a high multiplicity of secondary particles, long-distance multi-particle pseudo-rapidity correlations are observed. The distribution of average pseudo-rapidity in such events differs significantly from others, as it is much narrower, and its average value is noticeably shifted towards lower values <η>.
Beyond Reading: Psychological and Mental Health Needs in Adolescents with Dyslexia
Authors: Morte-Soriano Manuel-Ramón , Soriano-Ferrer Manuel
Published: October 2024

Background. Overall, children and adolescents diagnosed with dyslexia or ADHD show an increased risk for psychological and mental health problems, and dyslexia and ADHD tend to coexist frequently. Thus, the main objective of this study was to examine psychological and mental health problems in dyslexia. Method. Participated 95 adolescents with dyslexia (DG), comorbid dyslexia + attention-deficit hyperactivity disorder, combined subtype (D + ADHD-CG), and a comparison group with typical development (TDCG). Self-reported measures of anxiety and depression, and parent and teacher versions of the Strengths and Difficulties Questionnaire (SDQ) were used. Results. Self-reports of internalizing problems showed that adolescents in the GD and D + ADHD-CG groups had more depression and stated anxiety problems with a very high percentage above the clinical cut-off point than the CG. Both the parent and teacher reports showed that the DG and D + ADHD-CG groups obtained higher mean values and a higher number of adolescents above the clinical cut-off of internalizing, externalizing, and total problems than the TDCG. The comorbid D + ADHD-CG group had the highest internalizing and externalizing problems. Conclusions. In conclusion, our findings indicate that the internalizing and externalizing problems experienced by adolescents with dyslexia and comorbid ADHD should be recognized early and treated promptly by education professionals.
Growth Parameters and Prevalence of Obesity in PKU Patients and Peers: Is This the Right Comparison?
Authors: Paterno Giulia , Di Tullio Vito , Carella Rosa , De Ruvo Giada , Furioso Fabrizio , Skublewska-D’Elia Aleksandra , De Giovanni Donatella , Tummolo Albina
Published: October 2024

Background: One of the main objectives of Phenylketonuria (PKU) management is represented by optimising the growth trend under restricted protein diet regimen. The data on long-term growth in PKU children are limited and mostly based on earlier studies. Methods: The data for this twelve-year longitudinal study were collected from 34 PKU children and 37 healthy peers, whose auxological parameters were taken at 7 time-points over the follow-up. The weight-for-length ratio (WLR) z-score and body mass index (BMI) z-score were considered according to age. Prevalence of overweight/obesity was evaluated at last assessment. Results: The median BMI z-score of PKU children was normal and not statistically different from that of controls on all the seven time-point assessments. Their distributions tended to be wider than those of peers, with the upper limit exceeding the normal range since 12 months old, with a peak specifically at 3 years of age. In controls, there was a tendency to approach the BMI z-score values of overweight in later childhood. The prevalence of overweight was comparable (29% vs. 25%, p: 0.78) between the two groups at last assessment, and obese subjects (3/37) were only detected in the control group. Conclusions: In this study, we report data from a long-term follow-up on growth, highlighting that the median BMI z-score of PKU children was normal and not statistically different from that of controls. Also, the prevalence of obesity at 12 years of age was overlapping. However, the high prevalence of overweight children in the general population may explain the lack of difference and does not reassure about patients’ nutritional risk.
Parents’ Knowledge and Attitudes Toward Pediatric Ophthalmic Disorders in Saudi Arabia: A Cross-Sectional Study
Authors: Alanazi Saja Radhi G. , Alanazi Haneen Wadi H. , Alanazi Wasan Ghathwan , Alanazi Nawal Surhuj Q. , Alenezi Dareen Owaid B. , Al-Sweilem Maisa , Alqattan Maram Hassan , Alanazi Iftikhar Lafi N. , Tirksstani Jumanah Mohammed , AlSarhan Reem Saeed , Ghulaysi Saleh , Elgendy Hanan A. , Fawzy Manal S.
Published: October 2024

Recognizing pediatric eye health issues at an early stage, along with ensuring that parents are well informed, is crucial. This study measures parents’ knowledge and perspectives on pediatric ophthalmic disease. The study utilized a cross-sectional design, and participants included Saudi parents of children residing in Saudi Arabia. Data were collected using a pre-validated self-administered questionnaire with a scoring system. Sociodemographic characteristics and factors associated with knowledge/attitude were collected and analyzed. Initially, 425 respondents participated in this study. Excluding the participants whose work was related to healthcare and those with incomplete data yielded 370 responses on which the subsequent analyses were performed. The analysis revealed that only half of the parents recognized the need for annual eye examinations for children. Most of them showed gaps in knowledge regarding the frequency of routine eye exams and indicators of visual problems. Notably, parents with good/excellent knowledge were more proactive in their eye care practices, such as adherence to recommended eye examination schedules and accepting corrective measures like glasses for common conditions such as refractive errors and amblyopia. However, parental willingness to permit surgical interventions did not correlate significantly with their level of knowledge, signaling the influence of other factors. In conclusion, this study underscores the need for enhanced public health education to improve parental awareness of pediatric eye diseases in Saudi Arabia. Given the link between knowledge and proactive eye health practices, targeted interventions should distribute comprehensive, culturally sensitive information accessible to all demographics.
High-CBD Extract (CBD-X) in Asthma Management: Reducing Th2-Driven Cytokine Secretion and Neutrophil/Eosinophil Activity
Authors: Aswad Miran , Pechkovsky Antonina , Ghanayiem Narmeen , Hamza Haya , Dotan Yaniv , Louria-Hayon Igal
Published: October 2024

Background/Objectives: Asthma is a chronic inflammatory disorder of the airways affecting over 10% of the global population. It is characterized by airway inflammation, mucus hypersecretion, and bronchial hyperresponsiveness, driven predominantly by type 2 helper T cells (Th2) and type 2 innate lymphoid cells (ILC2s) in a subset of patients. However, a significant portion of asthmatic individuals present with “type 2-low” asthma that is often refractory to standard inhaled corticosteroid (ICS) therapy. Therefore, developing innovative therapeutic strategies has become essential. Recent studies have highlighted cannabidiol (CBD) as a promising anti-inflammatory agent capable of modulating immune responses. This study investigates the therapeutic potential of a high-CBD extract (CBD-X) in asthma. Methods: We evaluated the effects of CBD-X on cells involved in asthma pathogenesis using primary human Th2 cells, neutrophils, and asthma mouse model. Results: Our findings indicate that CBD-X extract inhibits Th2 differentiation and reduces the secretion of IL-5 and IL-13, which are crucial cytokines in asthma. Additionally, CBD-X significantly reduces pro-inflammatory cytokines IL-8 and IL-6 in neutrophils and impairs their migration, a critical step in airway inflammation. In a murine asthma model, CBD-X administration led to marked downregulation of IgE and pro-asthmatic cytokines, along with reduced leukocyte, eosinophil, and neutrophil infiltration in lung tissues. Conclusions: These results suggest that CBD-X extract could offer a novel and complementary approach to managing both type 2-high and type 2-low asthma by targeting key inflammatory pathways and modulating immune cell behavior.
Efficacy of Quercetin and Quercetin Loaded Chitosan Nanoparticles Against Cisplatin-Induced Renal and Testicular Toxicity via Attenuation of Oxidative Stress, Inflammation, and Apoptosis
Authors: Bakr Alaa F. , El-Shiekh Riham A. , Mahmoud Mohamed Y. , Khalil Heba M. A. , Alyami Mohammad H. , Alyami Hamad S. , Galal Omneya , Mansour Dina F.
Published: October 2024

Background/Objectives: Flavonoids, including quercetin, have attracted much attention due to their potential health-promoting effects. Methods: The current experiment aims to see whether quercetin (QUE) in nanoparticle form could mitigate testicular and renal toxicity caused by cisplatin (CIS) more effectively than normally formulated QUE. Rats were randomly treated with CIS alone or in combination with QUE or QUE.NPs (Quercetin-loaded chitosan nanoparticles) for 4 weeks. QUE and QUE.NPs were given orally (10 mg/kg, three times a week), while CIS was given intraperitoneally (2 mg/kg, twice a week). Results: Compared to QUE- and CIS + QUE.NP-treated rats, CIS exposure induced anxiety and emotional stress as well as promoted oxidative stress in both testicular and renal tissues. Moreover, CIS reduced serum testosterone levels and diminished testicular IL-10, as well as CIS-induced renal failure, as indicated by hypokalemia, and increased levels of creatinine, urea, sodium, IL-18, and KIM-1. Further, severe histological changes were observed in the testis and kidney of CIS-intoxicated rats. Regarding immunohistochemical staining, CIS significantly upregulated Bax, downregulated Bcl-2, and moderately enhanced PCNA expression. Conclusions: Our findings suggest that both QUE and QUE.NPs modulated emotional disturbance and improved testicular and renal functions via modulation of oxidation, inflammation, and apoptosis. However, QUE.NPs performed better than QUE-treated rats.
Real-Time Reconfigurable Radio Frequency Arbitrary-Waveform Generation via Temporal Pulse Shaping with a DPMZM and Multi-Tone Inputs
Authors: Chen Yireng , Lin Chenxiao , Yang Shuna , Yang Bo
Published: October 2024

Benefitting from a large bandwidth and compact configuration, a time-domain pulse-shaping (TPS) system provides possibilities for generating broadband radio frequency (RF) arbitrary waveforms based on the Fourier transform relationship between the input–output waveform pair. However, limited by the relatively low sampling rate and bit resolution of an electronic arbitrary-waveform generator (EAWG), the diversity and fidelity of the output waveform as well as its reconfiguration rate are constrained. To remove the EAWG’s limitation and realize dynamic real-time reconfiguration of RF waveforms, we propose and demonstrate a novel approach of RF arbitrary-waveform generation based on an improved TPS system with an integrated dual parallel Mach–Zehnder modulator (DPMZM) and multi-tone inputs. By appropriately adjusting the DC bias voltages of DPMZM and the power values, as well as the center frequencies of the multi-tone inputs, any desired RF arbitrary waveform can be generated and reconfigured in real time. Proof-of-concept experiments on the generation of different user-defined waveforms with a sampling rate up to 27 GSa/s have been successfully carried out. Furthermore, the impact of modulation modes and higher-order dispersion on waveform fidelity is also discussed in detail.
Research on Tracking Control Technology Based on Fuzzy PID in Underwater Optical Communication
Authors: Guan Dongliang , Liu Yang , Fu Jingyi , Teng Yunjie , Qian Yang , Wang Gongtan , Gu Sen , Liu Tongyu , Xi Wang
Published: October 2024

In order to realize effective laser communication on underwater mobile platforms, the active tracking and alignment technology of underwater laser communication (UWLC) is studied. Firstly, the servo control principle of the UWLC system is analyzed. Secondly, aiming at underwater disturbance, an adaptive fuzzy PID controller is designed to realize parameter self-tuning, thereby improving the system’s anti-disturbance ability. The designed algorithm was simulated, and the simulation results show that the adaptive fuzzy PID algorithm has better anti-disturbance ability and tracking performance than the traditional PID. Finally, an experimental platform was built for dynamic tracking experiments, and the results show that the dynamic tracking accuracy of the designed control algorithm was improved by 30.29% compared with the traditional control algorithm, which provides a certain reference for the development of laser communication on underwater moving platforms.
Solution Doping of PMMA-Based Step-Index Polymer Optical Fibers by Rhodamine B Near Glass Transition Temperature of PMMA
Authors: Ma Yinhua , Fu Dewen , Zhang Zhi-Feng
Published: October 2024

Solution doping is a facile approach to fabricating photoactive polymer optical fibers (POFs). However, previous studies reveal that only the cladding of step-index POFs can be doped by the solution doping method in methanol or aqueous solutions, whereas the fiber core is hardly doped. To dope the fiber core as well as the cladding, this study attempts to dope PMMA-based step-index POFs by raising the doping temperatures to near the Tg of PMMA. The results show that a considerable amount of rhodamine B (RhB) is doped in the fiber core, though the amount is still much less than that in the cladding. The highest content in the fiber core is 0.479 mg/g, which is achieved by doping the POFs in water at 110 °C for 8 h. At the same condition, the RhB content of the cladding is 11.5 mg/g. It is found that the high-temperature doping process leads to dramatic axial shrinkage and radial expansion of the POFs, due to the relaxation of the fiber core. The wrinkled cladding after doping suggests that the macromolecule orientation of the core is much higher than that of the cladding, and high orientation should be the main reason why the core is much more difficult to dope than the cladding. Additionally, the doping process at 90 °C in water does not increase the fiber loss regardless of the tremendous POF structure change. In short, the core of PMMA-based step-index POFs can be doped at a temperature near the Tg of the PMMA, making the solution doping technique more practicable for POF doping.