bluuebunny/crossref_metadata_2025 huggingface dataset:
Daptomycin: A Review 4 Years after First Approval
Authors: Sauermann Robert , Rothenburger Markus , Graninger Wolfgang , Joukhadar Christian
Published: October 2007

Daptomycin is the first approved member of a new class of antibiotics, namely the cyclic lipopeptides. Daptomycin has rapid bactericidal activity against Gram-positive pathogens. It acts by penetrating into the bacterial cell wall with consecutive formation of pores, loss of electrical membrane potential and inhibition of peptidoglycan synthesis. As the mode of action of daptomycin is ‘concentration-dependent’, the pharmacokinetic/pharmacodynamic indices that correlate best with its activity are the ratios of the peak concentration (Cmax) to minimum inhibitory concentration (MIC) or the area under the curve (24-hour AUC) to MIC. Daptomycin should be administered intravenously once daily, because adverse effects on skeletal muscle associated with an increase in plasma levels of creatine phosphokinase and myopathy were observed more frequently at shorter dosing intervals. Overall, the rate of adverse events during daptomycin therapy is comparable to that of other standard regimens. Daptomycin was shown to be not inferior to antimicrobial standard therapy and therefore was approved for complicated skin and skin structure infections at a dose of 4 mg/kg, for Staphylococcus aureus bacteremia and right-sided endocarditis at a dose of 6 mg/kg. Dosage regimens remain a matter of discussion, and an increase in the currently approved doses from 4–6 to 6–8 mg/kg per day for severe infections seems promising. Though not approved up to now, daptomycin appears to be a treatment alternative for Gram-positive bone and joint infections based on clinical observations. Large international studies showed high susceptibility of relevant Gram-positive pathogens to daptomycin, even in multidrug-resistant strains. Thus, treatment of infections caused by Gram-positive cocci resistant to other antimicrobial drugs is a potential indication of daptomycin. Since glycopeptides and daptomycin have the same target site, there appears to be a risk of reduced susceptibility to both drugs after consecutive use. Therefore, daptomycin should be used with caution for treatment of vancomycin-resistant isolates or after prior vancomycin (glycopeptide) therapy. This review describes the history, mechanism of action, susceptibility, recent discoveries and clinical experience regarding daptomycin, discussing its current role in the field of infectious diseases.
Omega–3 Fatty Acids, Inflammation and Angiogenesis: Nutrigenomic Effects as an Explanation for Anti-Atherogenic and Anti-Inflammatory Effects of Fish and Fish Oils
Authors: Massaro Marika , Scoditti Egeria , Carluccio Maria Annunziata , Montinari Maria Rosa , De Caterina Raffaele
Published: October 2007

Atherosclerosis is a dynamic process with inflammatory aspects playing a considerable pathogenetic role. In this process, the vascular endothelium is the key regulator of vascular function, promoting the maintenance of vascular homeostasis or the progression towards vascular disease. In the past 30 years, the dietary intake of omega–3 (n–3) polyunsaturated fatty acids – mainly derived from fish – has emerged as an important way to modify cardiovascular risk through beneficial effects on all stages of atherosclerosis. This review specifically focuses on the modulating effects of n–3 fatty acids on molecular events involved in early and late atherogenesis, including effects on endothelial expression of adhesion molecules, as well as pro-inflammatory and pro-angiogenic enzymes. By accumulating in endothelial membrane phospholipids, omega–3 fatty acids have been shown to decrease the transcriptional activation of several genes through a decreased activation of the nuclear factor-ĸB system of transcription factors. This occurs secondary to decreased generation of intracellular reactive oxygen species. This series of investigations configures a clear example of nutrigenomics, i.e. how nutrients may affect gene expression, ultimately affecting a wide spectrum of human diseases.
Gene-Nutrient Interactions in G6PD-Deficient Subjects – Implications for Cardiovascular Disease Susceptibility
Authors: Muntoni Sergio , Muntoni Sandro
Published: October 2007

Background/Aims: The enzyme glucose-6-phosphate dehydrogenase (G6PD) is the principal source of reducing equivalents, necessary for regenerating reduced glutathione through NADPH in order to protect cells from oxidative damage, and whichin erythrocytes produces hemolysis. When fava beans are ingested by G6PD-deficient subjects (gene-nutrient interaction), or some oxidant drugs are assumed (gene-drug interactions), a life-threatening hemolysis can occur. However, the same defect results in lower cardiovascular disease (CVD) risk. Methods: Physiopathological, clinical and mortality studies of CVD risk in relation with G6PD deficiency have been surveyed. Results: CVD risk in men was lowered in the G6PD-deficient state, and was associated with reduced levels of plasma low-density lipoprotein cholesterol (LDL-C) compared to the normal condition (p < 0.05). Both cholesterol and DNA synthesis in circulating mononuclear cells from G6PD-deficient men were likewise reduced (p = 0.05). Conclusions: Since NADPH is a necessary cofactor for the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA R), G6PD deficiency appears to be a naturally occurring model of HMG-CoA R restraint, whose consequences are similar to those produced on the same enzyme by statins. G6PD deficiency therefore results in protection against CVD, despite an increased susceptibility to oxidative stress.
Antioxidant-Mediated Effects in a Gerbil Model of Iron Overload
Authors: Otto-Duessel Maya , Aguilar Michelle , Moats Rex , Wood John C.
Published: October 2007

Introduction: Iron cardiomyopathy is a lethal complication of transfusion therapy in thalassemia major. Nutritional supplements decreasing cardiac iron uptake or toxicity would have clinical significance. Murine studies suggest taurine may prevent oxidative damage and inhibit Ca2+-channel-mediated iron transport. We hypothesized that taurine supplementation would decrease cardiac iron-overloaded toxicity by decreasing cardiac iron. Vitamin E and selenium served as antioxidant control. Methods: Animals were divided into control, iron, taurine, and vitamin E/selenium groups. Following sacrifice, iron and selenium measurements, histology, and biochemical analyses were performed. Results: No significant differences were found in heart and liver iron content between treatment groups, except for higher hepatic dry-weight iron concentrations in taurine-treated animals (p < 0.03). Serum iron increased with iron loading (751 ± 66 vs. 251 ± 54 µg/dl, p < 0.001) and with taurine (903 ± 136 µg/dl, p = 0.03). Conclusion: Consistent with oxidative stress, iron overload increased cardiac malondialdehyde levels, decreased heart glutathione peroxidase (GPx) activity, and increased serum aspartate aminotransferase. Taurine ameliorated these changes, but only significantly for liver GPx activity. Selenium and vitamin E supplementation did not improve oxidative markers and worsened cardiac GPx activity. These results suggest that taurine acts primarily as an antioxidant rather than inhibiting iron uptake. Future studies should illuminate the complexity of these results.
In vivo Magnetic Resonance Imaging of Atherosclerotic Lesions with a Newly Developed Evans Blue-DTPA-Gadolinium Contrast Medium in Apolipoprotein-E-Deficient Mice
Authors: Yasuda Satoshi , Ikuta Kenjiro , Uwatoku Toyokazu , Oi Keiji , Abe Kohtaro , Hyodo Fuminori , Yoshimitsu Kengo , Sugimura Kohtaro , Utsumi Hideo , Katayama Yoshiki , Shimokawa Hiroaki
Published: October 2007

Background: Magnetic resonance imaging (MRI) contrast agents that specifically detect atherosclerotic plaque may be useful for the noninvasive detection of the plaque. We have recently developed a new contrast agent, Evans blue-DTPA-gadolinium (EB-DTPA-Gd), which selectively accumulates vascular lesions with endothelial removal. In this study, we examined whether EB-DTPA-Gd is also useful for in vivo imaging of atherosclerotic plaques. Methods: We used male apolipoprotein-E-deficient (ApoE–/–) mice of different ages (3, 6 and 12 months old) and age-matched male wild-type mice. After a single intravenous administration of EB-DTPA-Gd (160 µM/kg body weight), MRI T1 signal was obtained in vivo. Results: Increased signal intensity in the aortic wall was noted within 10–20 min after intravenous injection of EB-DTPA-Gd and was maintained for 30 min. The MRI enhancement in the aorta of ApoE–/– mice was increased in accordance with age, whereas no such enhancement was noted in wild-type mice. Histological examination demonstrated that there was a topological correlation between the site of MRI enhancement and that of atherosclerotic plaque. Conclusions: These results indicate that EB-DTPA-Gd is a useful MRI contrast medium for the in vivo detection of atherosclerotic plaques.
The DSM-IV-TR ‘Glossary of Technical Terms’: A Reappraisal
Authors: Howsepian A.A.
Published: October 2007

Many of the entries in the Diagnostic and Statistical Manual of Mental Disorders, 4th edition – Text Revision (DSM-IV-TR) are problematic along multiple axes, including, but not limited to, clarity, logical coherence, factual content, redundancy, and ambiguity. These problems pose multiple barriers to clear, efficient, and accurate communication among those who work in clinical contexts or among those involved in psychological or psychiatric research. These barriers to communication, accurate concept formation, and clinical clarity affect diagnostic validity and reliability in a manner that imperils progress in psychiatry and psychology on a grand scale. This essay focuses on some of the most egregious problematic entries in the DSM-IV-TR’s ‘Glossary of Technical Terms’. It is meant to be a prolegomenon to a thorough revision of the Glossary in preparation for the projected 5th edition of the DSM.
Viral Vector-Mediated 12/15-Lipoxygenase Overexpression in Vascular Smooth Muscle Cells Enhances Inflammatory Gene Expression and Migration
Authors: Dwarakanath Roopashree S. , Sahar Saurabh , Lanting Linda , Wang Nanping , Stemerman Michael B. , Natarajan Rama , Reddy Marpadga A.
Published: October 2007

Increased expression and activity of 12/15-lipoxygenase (12/15-LO) in vascular smooth muscle cells (VSMCs) play a key role in the pathogenesis of diabetes and vascular complications. However, the consequences of 12/15-LO overexpression for VSMC migration and inflammatory gene expression are not known. In this study, 12/15-LO was overexpressed using adeno- and baculoviral vectors in human VSMC (HVSMCs) and proatherogenic responses compared with control enhanced green fluorescent protein (EGFP)-expressing cells. HVSMCs transduced with 12/15-LO viruses expressed high levels of enzymatically active protein and produced increased levels of the LO product, 12(S)-hydroxyeicosatetraenoic acid. 12/15-LO-overexpressing HVSMCs exhibited increased oxidant stress, activation of p38 mitogen-activated protein kinase, migration and inflammatory gene expression relative to HVSMCs expressing EGFP. Furthermore, inflammatory gene expression induced by 12/15-LO overexpression was abolished by anti-oxidants, siRNAs targeting p65 (nuclear factor-ĸB), or new-generation baculoviruses expressing inhibitory IĸBα or IĸBα superrepressor mutant. Thus, we have used novel viral vector delivery systems, including baculoviruses, for the first time to deliver foreign genes into VSMCs and thereby demonstrated that 12/15-LO overexpression increases oxidant stress, mitogen-activated protein kinase activation, migration and inflammatory genes in VSMCs and that NF-ĸB is a key downstream effector. Enhanced proatherogenic responses in VSMCs triggered by increased 12/15-LO levels under pathological conditions may contribute to vascular dysfunction.
Effect of Long-Term Type 1 Diabetes on Renal Sodium and Water Transporters in Rats
Authors: Vidotti Daniela B. , Arnoni Carine P. , Maquigussa Edgar , Boim Mirian A.
Published: October 2007

The effects of long-term diabetes in the presence of established nephropathy on tubular function remains poorly understood. We evaluated the levels of the main sodium and water transport proteins expressed in the kidney after long-term (8 weeks) of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in untreated (D) and insulin (4 U/s.c./day)-treated (D+I) rats. D animals presented upregulation (∼4.5-fold) of Na/glucose cotransporter (SGLT1), whereas the α-subunit of the epithelial sodium channel (α-ENaC) and aquaporin 1 (AQP1) were downregulated (∼20 and 30% respectively) with no change in the Na/H exchanger (NHE3), Na/Cl cotransporter (TSC) and AQP2. Insulin replacement partially prevented these alterations and caused increases in the expression of α-ENaC and AQP2. These effects suggest an action of insulin in the tubular transport properties. The upregulation of SGLT1 may constitute a mechanism to prevent greater glucose losses in the urine but it may result in glucotoxicity to the proximal epithelial cells contributing to the diabetic nephropathy. The decrease of α-ENaC in D animals may compensate for the increased sodium reabsorption via SGLT1 resulting in discrete natriuresis. DM-induced polyuria was not due to changes in AQP2 expression.
Relationship between G-Protein Beta-3 Subunit C825T Polymorphism and Mirtazapine Responses in Korean Patients with Major Depression
Authors: Kang Rhee-Hun , Hahn Sang-Woo , Choi Myoung-Jin , Lee Min-Soo
Published: October 2007

Aims: This study aimed to determine the relationship between the C825T polymorphism in the G-protein β3 subunit (GNB3) gene and the response to mirtazapine in a Korean population with major depressive disorder (MDD). Method: Mirtazapine was administered for 8 weeks to the 101 MDD patients who completed this study. All subjects were examined using the Structured Clinical Interview for DSM-IV, and the severity of depression was assessed using the 21-item Hamilton Depression Rating (HAMD-21) scale. Results: There was a significant main effect of time on the decrease in the HAMD-21 score during the 8-week study period. However, a main effect of or an interaction of genotype with time on the decrease in the HAMD-21 score during the 8-week study period was not found. ANOVA revealed no significant effects of the GNB3 C825T polymorphism on the decrease in the HAMD-21 score at each time period. Conclusion: Although the C825T polymorphism of the GNB3 gene may affect the pathogenesis of MDD, our results do not support the hypothesis that this polymorphism is involved in the therapeutic response to mirtazapine in Korean patients with MDD.
Alcohol Consumption Is Associated with an Interaction between DRD2 Exon 8 A/A Genotype and Self-Directedness in Males
Authors: Lucht Michael , Barnow Sven , Schroeder Winnie , Grabe Hans Joergen , Rosskopf Dieter , Brummer Christian , John Ulrich , Freyberger Harald J. , Herrmann Falko H.
Published: October 2007

Background: Both reduced postsynaptic dopamine D2 receptor function and the character variable self-directedness (SDD) are related to the level of alcohol consumption. We examined for interactions between DRD2 exon 8(rs6276), a polymorphism which has been associated with various alcohol-related phenotypes, SDD and alcohol consumption. Methods:A total of 144 male and 186 female probands with alcohol dependence or abuse diagnoses and without were included in the study. All subjects were assessed with the alcohol section of the Semi-Structured Assessment for the Genetics of Alcoholism and the Temperament and Character Inventory. Results: Male probands with A/A genotype reported significantly higher alcohol consumption in a typical week (ANOVA; p = 0.024); those with A/A genotype and low SDD showed particularly high consumption levels (interaction DRD2 × SDD: p = 0.019). Alcohol dependence/abuse (DSM-IV) but not nicotine dependence was also relevant for higher alcohol consumption (trend: p = 0.052). In the female group, only alcohol disorders predicted alcohol consumption. Conclusions:Our findings support a role for a gene-personality interaction of DRD2 exon 8 × SDD in alcohol consumption in males.
Acute Eosinophilic Pneumonia Complicating Coccidioides immitis Pneumonia: A Case Report and Literature Review
Authors: Swartz Justin , Stoller James K.
Published: October 2007

Though peripheral eosinophilia commonly accompanies infection with Coccidioides immitis, pulmonary eosinophilia in patients with C. immitis and multilobar infiltrates has been reported in only three prior cases to our knowledge. To enhance clinicians’ suspicion of an unusual complication of C. immitis pneumonia and the treatment implications, we present a patient with an initial diagnosis of acute eosinophilic pneumonia [based on bronchoalveolar lavage (BAL) fluid analysis and transbronchial biopsy] followed several days later by a diagnosis of accompanying C. immitis pneumonia when BAL fluid cultures grew fungus. In keeping with the suspicion of acute eosinophilic pneumonia, the patient responded dramatically to corticosteroids before antifungal therapy was initiated. This patient with pulmonary eosinophilia complicating C. immitis pneumonia extends earlier reports of a hypersensitivity-like reaction to C. immitis pneumonia and, based on the dramatic acute clinical response, reminds clinicians of the potential adjunctive role of corticosteroids. At the same time, the possible adverse effects of using corticosteroids in patients with fungal disease warrants caution and close follow-up in patients for whom steroids are prescribed.
Comparison of Intraperitoneal with Intravenous Administration of Taxol in Experimental Peritoneal Carcinomatosis
Authors: Hribaschek Arndt , Meyer Frank , Schneider-Stock Regine , Pross Matthias , Ridwelski Karsten , Lippert Hans
Published: October 2007

Background: Recurrent tumor growth of colorectal carcinoma at the peritoneal site remains an unsolved problem. The aim of this study was to investigate whether the substance taxol (paclitaxel) can alter intraperitoneal tumor spread using different modes of drug application. Methods: Intraperitoneal tumor growth was induced using a tumor cell transfer model (106 cells) in rats divided into 3 groups: (1) taxol was applied directly into the abdominal cavity, intraperitoneally or intravenously, immediately following intraperitoneal tumor cell transfer; (2) early postoperative intraperitoneal and intravenous chemotherapy was administered on days 5, 10 and 15 after surgical intervention using an intraperitoneal or intravenous port-a-cath; (3) control group. Thirty days after tumor cell transfer, rats were sacrificed, and tumor weight, number of nodes (at greater omentum and peritoneum) and ascites volume were determined. Results: Taxol generated a significant inhibitory effect on peritoneal tumor growth. Direct intraoperative intraperitoneal application of taxol induced a more pronounced effect compared with early postoperative intraperitoneal application of the antineoplastic drug. Both application modes were superior to the intravenous route (no significant effect). Conclusion: Taxol appears to be a potential chemotherapeutic drug providing a significant effect in the therapeutic management of peritoneal carcinomatosis under experimental conditions. Combination of taxol with cytostatic agents and new drugs generating different effector mechanisms may help to further diminish or even to prevent intraperitoneal tumor growth.
“No Fixed Values”: A Reinterpretation of the Influence of the Theory of Guerre Révolutionnaire and the Battle of Algiers, 1956–1957
Authors: Cradock Christopher , Smith M. L. R.
Published: October 2007

The so-called Battle of Algiers (1956–1957) was a pivotal event in the history of French decolonization and was controversial because it involved brutality and the use of torture. The tactical success of the French Army in the battle has been credited to the theory of guerre révolutionnaire, which evolved in French military thinking after the army's debacle in Indochina. The theory situated anti-colonial insurgencies within the Cold War struggle of Western values against Communism. This article reevaluates earlier claims about the theory's efficacy and shows that ultimately the methods used by the French during the Battle of Algiers can be explained more by factors related to the contingent historical experiences of the French army than by the influence of guerre révolutionnaire.
Winds of Change and Links of Continuity: A Study on the Merchant Groups of Kerala and the Channels of their Trade, 1000-1800
Authors: Malekandathil Pius
Published: October 2007

The diverse merchant groups that participated in maritime trade emanating from the various exchange centers of Kerala during this period acted within the framework of certain socioeconomic conditions that ensured a remarkable degree of continuity as far as their organizational arrangements and distribution networks were concerned.Familiarization with frequent socio-political changes in the maritime exchange centers of Kerala, which were then exposed to frequent expansionist moves of inland rulers in the initial phase and of European commercial powers in the later periods, gave a great amount of adaptability to the different mercantile groups involved in its maritime trade, capacitating them to develop multiple survival strategies. Different segments of traders, who were unified by the commonality of religion, as in the case of Muslim merchants, developed diverse but better strategies to overcome Portuguese control systems as well as to ensure continuity in trade. Différents groupes marchands étaient engagés, durant cette période, dans le commerce maritime entre les divers centres d'échanges du Kerala. Ils menaient leurs activités dans un cadre où certaines conditions socio-économiques assuraient à leurs réseaux d'organisation et de distribution un remarquable degré de continuité. Avec l'expérience acquise face aux changements fréquents intervenus dans les échanges maritimes entre les divers centres du Kerala à la suite des mouvements d'expansion des souverains de l'intérieur dans un premier temps, et des puissances européennes par la suite, ils surent s'adapter et développer de multiples stratégies de survie face aux divers groupes de marchands impliqués dans le commerce maritime. Unis par une religion commune, tels les marchands musulmans, ils surent par exemple contourner le contrôle mis en place par les Portugais, et garantir la continuité de leurs activités commerciales.
"Correspondence is equal to half a meeting": The Composition and Comprehension of Letters in Eighteenth-century Islamic Eurasia
Authors: Sood Gagan
Published: October 2007

This article details the social and cultural mechanisms by which correspondence in Arabic- and Latin-script languages was written, understood and preserved in mid-eighteenth-century Islamic Eurasia. Aside from two major differences in letter-writing culture, which were embodied in the choice of script, the resident communities of Islamic Eurasia approached correspondence in a similar fashion. Perhaps surprisingly, there is no correlation between these practices and the author's ethnicity or nationality. This is strong evidence for the autonomy and universality of custom in a region on the cusp of massive changes in its relationship to Europe. Cette contribution détaille les mécanismes sociaux et culturels par lesquels la correspondance en langues et caractères arabes et latins fut rédigée, comprise et préservée en Eurasie Islamique au milieu du dix-huitième siècle. À l'exception de deux différences clés dans les pratiques épistolaires – exprimées dans le choix de l'écriture utilisée – les communautés de l'Eurasie Islamique abordèrent la correspondance d'une manière semblable. Qu'il n'y ait aucune corrélation entre ces pratiques et l'ethnicité ou la nationalité de l'auteur surprend; mais c'est une preuve notable de l'autonomie et de l'universalité des coutumes dans une région qui parvenait à l'apogée de transformations majeures dans ses relations avec l'Europe.
From Color Naming to a Language Space: An Analysis of Data from the World Color Survey
Authors: Bimler David
Published: October 2007

The World Color Survey was a large-scale cross-cultural experiment in which informants used the color lexicons of 110 non-written languages to label a standard set of stimuli. Here those data are explored with a novel analysis which focuses on the averaged location of boundaries within the stimulus set, revealing the system of color categories native to each language. A quantitative index of inter-language similarity was defined, comparing these average boundaries. Analyzing the similarities among color-naming patterns led to a 'language space', in which languages are grouped into clusters according to linguistic families (i.e., descent from common ancestors). This implies that each language's departures from the cross-cultural consensus about color categories are systematic (non-random). Given the non-unanimity about the color lexicon within languages, the persistence of these language families across the course of linguistic evolution is paradoxical.
Imagery Effects on Recall of Minimally Counterintuitive Concepts
Authors: Slone D. Jason , Gonce Lauren , Upal Afzal , Edwards Kristin , Tweney Ryan
Published: October 2007

Much experimental evidence shows that minimally counterintuitive concepts, which violate one intuitive ontological expectation of domain-specific natural kinds, are remembered as well as or better than intuitive concepts with no violations of ontological expectations, and much better than maximally counterintuitive concepts with more than one violation of ontological violations (Barrett and Nyhoff, 2001; Boyer and Ramble, 2001; Atran and Norenzayan, 2004; Gonce et al., 2006). It is also well established that concepts rated as high in imagery, (e.g., apple) are recalled better than concepts that are low in imagery (e.g., justice; see Paivio, 1990). We conducted three studies to test whether imagery levels affected recall rates of intuitive, minimally counterintuitive, and maximally counterintuitive concepts. In study 1, we obtained imagery level ratings for 48 three-word items. In study 2, we used the ratings obtained in study 1 in a 2 × 3 recall task in which imagery (high vs. low) was manipulated along with counterintutiveness (intuitive vs. minimally counterintuitive vs. maximally counterintuitive). High imagery items were recalled significantly better than low imagery items for intuitive and maximally counterintuitive items but not for minimally counterintuitive items. Study 3, replicated the findings from study 2 in a 2 × 2 study using a larger number of intuitive and minimally counterintuitive items. In both studies, High imagery items were recalled significantly better than low imagery items for intuitive but not for minimally counterintuitive items. Thus, minimally counterintuitive concepts appear insulated from imagery effects on recall.
Morphometry of the testis follicles in Triatoma rubrofasciata (De Geer, 1773) (Hemiptera, Triatominae)
Authors: Freitas Simone Patrícia Carneiro , Santos-Mallet Jacenir Reis Dos , Serrão José Eduardo , Lorosa Elias Seixas , Gonçalves Teresa Cristina Monte
Published: October 2007

The male reproductive tract in Triatominae has a pair of testes, two vasa deferentia, a pair of seminal vesicles, four pairs of accessory glands, and an ejaculatory duct, which opens in the aedeagus. In species of the genus Triatoma each testis is formed by seven testicular follicles. Because Triatoma rubrofasciata has a common ancestor with species of Triatoma occurring in North America and because the length of testis follicles varies among different species of Triatoma a morphometrical analysis of the follicles was conducted. Triatoma rubrofasciata has seven testis follicles of variable length that are similar between left and right testes. The statistics allowed the classification in a long follicle, two medium follicles, two that are short, and two that are very short. This finding is compared with data available for other Triatominae and it is emphasized that the length of follicles testis should be included in future phylogenetic analysis of Triatominae.
Performance of a pool-and-weir fish pass for small bottom-dwelling freshwater fish species in a regulated lowland river
Authors: Knaepkens Guy , Maerten Evelien , Eens Marcel
Published: October 2007

Although small benthic freshwater fish species are an important biological component of fish assemblages and free instream movement is indispensable for their survival, they are often neglected in fish pass performance studies. In this study, a capture-mark-recapture approach was used to assess whether small bottom-dwelling species, including gudgeon (Gobio gobio), stone loach (Barbatula barbatula), spined loach (Cobitis taenia) and bullhead (Cottus gobio), were able to cross a pool-and-weir fish pass in a regulated lowland river. Some tagged individuals of stone loach (18%), gudgeon (7%) and spined loach (2%) managed to successfully ascend the fish pass under study, despite the fact that water velocity levels in the different overflows of the facility (between 0.55-1.22 m/s) exceeded the critical swimming speed of all three species. Although this suggests that a pool-and-weir fish pass is a able to facilitate upstream movement of some small benthic species in a regulated river, more detailed research incorporating advanced tagging and retrieving techniques is necessary.
The Interannual Variability of Tropical Cyclones
Authors: Frank William M. , Young George S.
Published: October 2007

This paper examines the interannual variability of tropical cyclones in each of the earth’s cyclone basins using data from 1985 to 2003. The data are first analyzed using a Monte Carlo technique to investigate the long-standing myth that the global number of tropical cyclones is less variable than would be expected from examination of the variability in each basin. This belief is found to be false. Variations in the global number of all tropical cyclones are indistinguishable from those that would be expected if each basin was examined independently of the others. Furthermore, the global number of the most intense storms (Saffir–Simpson categories 4–5) is actually more variable than would be expected because of an observed tendency for storm activity to be correlated between basins, and this raises important questions as to how and why these correlations arise. Interbasin correlations and factor analysis of patterns of tropical cyclone activity reveal that there are several significant modes of variability. The largest three factors together explain about 70% of the variance, and each of these factors shows significant correlation with ENSO, the North Atlantic Oscillation (NAO), or both, with ENSO producing the largest effects. The results suggest that patterns of tropical cyclone variability are strongly affected by large-scale modes of interannual variability. The temporal and spatial variations in storm activity are quite different for weaker tropical cyclones (tropical storm through category 2 strength) than for stronger storms (categories 3–5). The stronger storms tend to show stronger interbasin correlations and stronger relationships to ENSO and the NAO than do the weaker storms. This suggests that the factors that control tropical cyclone formation differ in important ways from those that ultimately determine storm intensity.
Prediction of the Diurnal Change Using a Multimodel Superensemble. Part I: Precipitation
Authors: Krishnamurti T. N. , Gnanaseelan C. , Chakraborty A.
Published: October 2007

Modeling the geographical distribution of the phase and amplitude of the diurnal change is a challenging problem. This paper addresses the issues of modeling the diurnal mode of precipitation over the Tropics. Largely an early morning precipitation maximum over the oceans and an afternoon rainfall maximum over land areas describe the first-order diurnal variability. However, large variability in phase and amplitude prevails even within the land and oceanic areas. This paper addresses the importance of a multimodel superensemble for much improved prediction of the diurnal mode as compared to what is possible from individual models. To begin this exercise, the skills of the member models, the ensemble mean of the member models, a unified cloud model, and the superensemble for the prediction of total rain as well as its day versus night distribution were examined. Here it is shown that the distributions of total rain over the earth (tropical belt) and over certain geographical regions are predicted reasonably well (RMSE less than 18%) from the construction of a multimodel superensemble. This dataset is well suited for addressing the diurnal change. The large errors in phase of the diurnal modes in individual models usually stem from numerous physical processes such as the cloud radiation, shallow and deep cumulus convection, and the physics of the planetary boundary layer. The multimodel superensemble is designed to reduce such systematic errors and provide meaningful forecasts. That application for the diurnal mode appears very promising. This paper examines some of the regions such as the Tibetan Plateau, the eastern foothills of the Himalayas, and the Amazon region of South America that are traditionally difficult for modeling the diurnal change. In nearly all of these regions, errors in phase and amplitude of the diurnal mode of precipitation increase with the increased length of forecasts. Model forecast errors on the order of 6–12 h for phase and 50% for the amplitude are often seen from the member models. The multimodel superensemble reduces these errors and provides a close match (RMSE < 6 h) to the observed phase. The percent of daily rain and their phases obtained from the multimodel superensemble at 3-hourly intervals for different regions of the Tropics showed a closer match (pattern correlation about 0.4) with the satellite estimates. This is another area where the individual member models conveyed a much lower skill.
The Influence of Horizontal Environmental Variability on Numerically Simulated Convective Storms. Part I: Variations in Vertical Shear
Authors: Richardson Yvette P. , Droegemeier Kelvin K. , Davies-Jones Robert P.
Published: October 2007

Severe convective storms are typically simulated using either an idealized, horizontally homogeneous environment (i.e., single sounding) or an inhomogeneous environment constructed using numerous types of observations. Representing opposite ends of the spectrum, the former allows for the study of storm dynamics without the complicating effects of either land surface or atmospheric variability, though arguably at the expense of physical realism, while the latter is especially useful for prediction and data sensitivity studies, though because of its physical completeness, determination of cause can be extremely difficult. In this study, the gap between these two extremes is bridged by specifying horizontal variations in environmental vertical shear in an idealized, controlled manner so that their influence on storm morphology can be readily diagnosed. Simulations are performed using the Advanced Regional Prediction System (ARPS), though with significant modification to accommodate the analytically specified environmental fields. Several steady-state environments are constructed herein that retain a good degree of physical realism while permitting clear interpretation of cause and effect. These experiments are compared to counterpart control simulations in homogeneous environments constructed using single wind profiles from selected locations within the inhomogeneous environment domain. Simulations in which steady-state vertical shear varies spatially are presented for different shear regimes (storm types). A gradient of weak shear across the storm system leads to preferred cell development on the flank with greater shear. In a stronger shear regime (i.e., in the borderline multicell/supercell regime), however, cell development is enhanced on the weaker shear flank while cell organization is enhanced on the strong shear side. When an entire storm system moves from weak to strong shear, changes in cell structure are influenced by local mesoscale forcing associated with the cold pool. In this particular experiment, cells near the leading edge of the cold pool, where gust front convergence occurs along a continuous line, evolve into a bow-echo structure as the shear increases. In contrast, simulated cells that remain relatively isolated on the flank of the cold pool tend to develop supercellular characteristics.
System Design and Evaluation of Coupled Ensemble Data Assimilation for Global Oceanic Climate Studies
Authors: Zhang S. , Harrison M. J. , Rosati A. , Wittenberg A.
Published: October 2007

A fully coupled data assimilation (CDA) system, consisting of an ensemble filter applied to the Geophysical Fluid Dynamics Laboratory’s global fully coupled climate model (CM2), has been developed to facilitate the detection and prediction of seasonal-to-multidecadal climate variability and climate trends. The assimilation provides a self-consistent, temporally continuous estimate of the coupled model state and its uncertainty, in the form of discrete ensemble members, which can be used directly to initialize probabilistic climate forecasts. Here, the CDA is evaluated using a series of perfect model experiments, in which a particular twentieth-century simulation—with temporally varying greenhouse gas and natural aerosol radiative forcings—serves as a “truth” from which observations are drawn, according to the actual ocean observing network for the twentieth century. These observations are then assimilated into a coupled model ensemble that is subjected only to preindustrial forcings. By examining how well this analysis ensemble reproduces the “truth,” the skill of the analysis system in recovering anthropogenically forced trends and natural climate variability is assessed, given the historical observing network. The assimilation successfully reconstructs the twentieth-century ocean heat content variability and trends in most locations. The experiments highlight the importance of maintaining key physical relationships among model fields, which are associated with water masses in the ocean and geostrophy in the atmosphere. For example, when only oceanic temperatures are assimilated, the ocean analysis is greatly improved by incorporating the temperature–salinity covariance provided by the analysis ensemble. Interestingly, wind observations are more helpful than atmospheric temperature observations for constructing the structure of the tropical atmosphere; the opposite holds for the extratropical atmosphere. The experiments indicate that the Atlantic meridional overturning circulation is difficult to constrain using the twentieth-century observational network, but there is hope that additional observations—including those from the newly deployed Argo profiles—may lessen this problem in the twenty-first century. The challenges for data assimilation of model systematic biases and evolving observing systems are discussed.
Comparison of the Diurnal Precipitation Cycle in Convection-Resolving and Non-Convection-Resolving Mesoscale Models
Authors: Clark Adam J. , Gallus William A. , Chen Tsing-Chang
Published: October 2007

The diurnal cycles of rainfall in 5-km grid-spacing convection-resolving and 22-km grid-spacing non-convection-resolving configurations of the Weather Research and Forecasting (WRF) model are compared to see if significant improvements can be obtained by using fine enough grid spacing to explicitly resolve convection. Diurnally averaged Hovmöller diagrams, spatial correlation coefficients computed in Hovmöller space, equitable threat scores (ETSs), and biases for forecasts conducted from 1 April to 25 July 2005 over a large portion of the central United States are used for the comparisons. A subjective comparison using Hovmöller diagrams of diurnally averaged rainfall show that the diurnal cycle representation in the 5-km configuration is clearly superior to that in the 22-km configuration during forecast hours 24–48. The superiority of the 5-km configuration is validated by much higher spatial correlation coefficients than in the 22-km configuration. During the first 24 forecast hours the 5-km model forecasts appear to be more adversely affected by model “spinup” processes than the 22-km model forecasts, and it is less clear, subjectively, which configuration has the better diurnal cycle representation, although spatial correlation coefficients are slightly higher in the 22-km configuration. ETSs in both configurations have diurnal oscillations with relative maxima occurring in both configurations at forecast hours corresponding to 0000–0300 LST, while biases also have diurnal oscillations with relative maxima (largest errors) in the 22-km (5-km) configuration occurring at forecast hours corresponding to 1200 (1800) LST. At all forecast hours, ETSs from the 22-km configuration are higher than those in the 5-km configuration. This inconsistency with some of the results obtained using the aforementioned spatial correlation coefficients reinforces discussion in past literature that cautions against using “traditional” verification statistics, such as ETS, to compare high- to low-resolution forecasts.
Multiple-Radar Data Assimilation and Short-Range Quantitative Precipitation Forecasting of a Squall Line Observed during IHOP_2002
Authors: Xiao Qingnong , Sun Juanzhen
Published: October 2007

The impact of multiple–Doppler radar data assimilation on quantitative precipitation forecasting (QPF) is examined in this study. The newly developed Weather Research and Forecasting (WRF) model Advanced Research WRF (ARW) and its three-dimensional variational data assimilation system (WRF 3DVAR) are used. In this study, multiple–Doppler radar data assimilation is applied in WRF 3DVAR cycling mode to initialize a squall-line convective system on 13 June 2002 during the International H2O Project (IHOP_2002) and the ARW QPF skills are evaluated for the case. Numerical experiments demonstrate that WRF 3DVAR can successfully assimilate Doppler radial velocity and reflectivity from multiple radar sites and extract useful information from the radar data to initiate the squall-line convective system. Assimilation of both radial velocity and reflectivity results in sound analyses that show adjustments in both the dynamical and thermodynamical fields that are consistent with the WRF 3DVAR balance constraint and background error correlation. The cycling of the Doppler radar data from the 12 radar sites at 2100 UTC 12 June and 0000 UTC 13 June produces a more detailed mesoscale structure of the squall-line convection in the model initial conditions at 0000 UTC 13 June. Evaluations of the ARW QPF skills with initialization via Doppler radar data assimilation demonstrate that the more radar data in the temporal and spatial dimensions are assimilated, the more positive is the impact on the QPF skill. Assimilation of both radial velocity and reflectivity has more positive impact on the QPF skill than does assimilation of either radial velocity or reflectivity only. The improvement of the QPF skill with multiple-radar data assimilation is more clearly observed in heavy rainfall than in light rainfall. In addition to the improvement of the QPF skill, the simulated structure of the squall line is also enhanced by the multiple–Doppler radar data assimilation in the WRF 3DVAR cycling experiment. The vertical airflow pattern shows typical characteristics of squall-line convection. The cold pool and its related squall-line convection triggering process are better initiated in the WRF 3DVAR analysis and simulated in the ARW forecast when multiple–Doppler radar data are assimilated.
Total Lightning Signatures of Thunderstorm Intensity over North Texas. Part I: Supercells
Authors: Steiger Scott M. , Orville Richard E. , Carey Lawrence D.
Published: October 2007

It is shown that total lightning mapping, along with radar and National Lightning Detection Network (NLDN) cloud-to-ground lightning data, can be used to diagnose the severity of a thunderstorm. Analysis of supercells, some of which were tornadic, on 13 October 2001 over Dallas–Fort Worth, Texas, shows that Lightning Detection and Ranging (LDAR II) lightning source heights (quartile, median, and 95th percentile heights) increased as the storms intensified. Most of the total (cloud to ground and intracloud) lightning occurred where reflectivity cores extended upward, within regions of strong reflectivity gradient rather than in reflectivity cores. A total lightning hole was associated with an intense, nontornadic supercell on 6 April 2003. None of the supercells on 13 October 2001 exhibited a lightning hole. During tornadogenesis, the radar and LDAR II data indicated updraft weakening. The height of the 30-dBZ radar top began to descend approximately 10 min (2 volume scans) before tornado touchdown in one storm. Total lightning and cloud-to-ground flash rates decreased by up to a factor of 5 to a minimum during an F2 tornado touchdown associated with this storm. LDAR II source heights all showed descent by 2–4 km during a 25-min period prior to and during this tornado touchdown. This drastic trend of decreasing source heights prior to and during tornado touchdown was observed in two storms, but did not occur in nontornadic supercells, suggesting that these parameters can be useful to forecasters. These observations agree with tornadogenesis theory that as the updraft weakens, the mesocyclone can divide (into an updraft and downdraft) and become tornadic.
Probabilistic Forecasts of the Onset of the North Australian Wet Season
Authors: Lo Fiona , Wheeler Matthew C. , Meinke Holger , Donald Alexis
Published: October 2007

The amount and timing of early wet-season rainfall are important for the management of many agricultural industries in north Australia. With this in mind, a wet-season onset date is defined based on the accumulation of rainfall to a predefined threshold, starting from 1 September, for each square of a 1° gridded analysis of daily rainfall across the region. Consistent with earlier studies, the interannual variability of the onset dates is shown to be well related to the immediately preceding July–August Southern Oscillation index (SOI). Based on this relationship, a forecast method using logistic regression is developed to predict the probability that onset will occur later than the climatological mean date. This method is expanded to also predict the probabilities that onset will be later than any of a range of threshold dates around the climatological mean. When assessed using cross-validated hindcasts, the skill of the predictions exceeds that of climatological forecasts in the majority of locations in north Australia, especially in the Top End region, Cape York, and central Queensland. At times of strong anomalies in the July–August SOI, the forecasts are reliably emphatic. Furthermore, predictions using tropical Pacific sea surface temperatures (SSTs) as the predictor are also tested. While short-lead (July–August predictor) forecasts are more skillful using the SOI, long-lead (May–June predictor) forecasts are more skillful using Pacific SSTs, indicative of the longer-term memory present in the ocean.