bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of F/Mn-doped CsPb(Br/Cl)3 quantum-dot glass and their luminescence properties
Authors: Sun Zhuqing , Li Yongxia , Bai Haowen , Jin Shenghang , Zhang Haibo , Cao Guanying
Published: May 2024

All inorganic lead halide cesium perovskite quantum dots (QDs) have attracted much attention due to their excellent luminescence properties, but further development is restricted by their stability and the existence of toxic element lead. In this paper, F/Mn-doped [Formula: see text] QDs glass was prepared by melt quenching and heat treatment, with reduced Pb content effectively. The result shows that the spectrum of the QD glass is adjustable between 450 nm and 515.4 nm by changing the feeding ratio of Mn-Pb ion and heat treatment temperature. Moreover, the indraught of [Formula: see text] effectively improves the PLQY of [Formula: see text] QDs glass and serves as a red-emitting. The prepared composites not only maintain good fluorescence characteristics, but also greatly improve the stability of QDs. And successfully coupled with blue LED chips to synthesize WLED, Under 20 mA current, the color coordinate is (0.3446, 0.3389).
Unintended Consequences of Technostress Mitigation: An Employee Perspective on the Effectiveness of Mitigation Measures
Authors: Reis Lea , Maier Christian , Pflügner Katharina , Weitzel Tim
Published: May 2024

The continuous use of IT, even beyond regular office hours, is considered a cause of technostress, which impairs the health and performance of employees. To mitigate technostress, European countries have established the right to disconnect, and many organizations are struggling to identify and implement other effective measures. Based on a qualitative study (N=30) with 23 IT workers, five managers, and two CIOs, this study identifies eight technological, social, and cultural measures to mitigate common techno-stressors. By focusing on the employees' perspective, the results reveal the extent to which the measures actually work, showing that well-intended countermeasures, such as email restrictions, might have unintended negative and even harmful side effects. Our analysis shows that mitigation measures seldom work in isolation and without spillover effects. We conclude that although technostress mitigation is complex and mitigation measures adopted in isolation can fail and sometimes cause additional harm, employees still appreciate the effort.
A Bifunctional Electrocatalyst of Flower-Like Cr-Doped CoP/Fe2P Microsphere for Efficient Overall Water Splitting
Authors: Yan Yu , Li Dongxiao , Guo Zhimin , Ren Hao , Huang Yubiao , Yan Bei , Zhao Ruihuan , Yao Xin
Published: May 2024

Developing efficient, low-price non-noble metal-based electrocatalysts for overall water splitting in alkaline medium remains a formidable challenge. In our work, Cr-doped CoP/Fe2P (Cr-CoP/Fe2P) flower-like microsphere was synthesized through a simple hydrothermal and phosphating process. The resulting Cr-CoP/Fe2P electrocatalyst shows significantly enhanced oxygen evolution reaction performance (262 mV @ 10 mA cm−2) and has a satisfactory hydrogen evolution reaction performance (114 mV @ 10 mA cm−2), coupled with favorable stability in an alkaline medium. Furthermore, when assembling Cr-CoP/Fe2P into an electrolytic cell, the two-electrode system can provide a current density of 10 mA cm−2 at a voltage of 1.61 V. At high current density, the performance of the electrolytic cell composed of Cr-CoP/Fe2P is superior to that of noble metal catalyst electrode pair. Electronic structure analysis and various characterizations confirm that Cr doping and the formation of CoP/Fe2P heterogeneous interfaces redistribute the electron densities of the active sites, enlarge the specific surface area, and enhance the aerophobicity of the catalysts, thereby improving the electrocatalytic property. This work provides a referable method for engineering highly efficient and stable non-noble polymetallic phosphides, which serve as bifunctional electrocatalyst for overall water splitting.
Performance and Degradation of Electrolyte Supported SOECs with Advanced Thin-Film Gadolinium Doped Ceria Barrier Layers in Long-Term Stack Test
Authors: Han Feng , Lang Michael , Szabo Patric , Geipel Christian , Walter Christian , Costa Rémi
Published: May 2024

Electrolyte supported Solid Oxide Cells (ESCs) with advanced thin-film Gd-doped ceria diffusion barrier layers between electrolyte and electrodes were assembled and electrochemically investigated in steam electrolysis mode in a so-called “rainbow” stack with 30 repeat units (RUs). The barrier layers were deposited onto the electrolyte supports via electron-beam physical evaporation deposition (EB-PVD) method at 600 °C. In this paper, the investigation mainly focuses on the electrochemical characteristics of RUs containing the EB-PVD thin-film GDC layers. At the initial stage of the SOEC operation, the stack reached a high performance with an electrical efficiency of 99.65% at 75% steam conversion and a total power input of 1.98 kW. A long-term stack test was performed in SOEC mode for over 5000 h and demonstrated a low voltage degradation of approx. +11.3 mV·kh–1 per RU (+0.9% kh–1). The RUs with EB-PVD GDC thin-films revealed similar initial performance and degradation rate to the state-of-the-art cells with screen printed GDC layers.
Comparative Analysis of Reverse Truncated Pyramid and Other Nonimaging Concentrators as the Receiver in Laser Wireless Power Transmission System
Authors: Meng Xian-long , Li Xin-yuan , Hou Yi-chao , Zhang Pu , Liu Cun-liang
Published: May 2024

The global energy landscape faces significant challenges in meeting the demands of modern industries for stable and efficient energy supply. Laser wireless power transmission (LWPT) systems, which utilize the photovoltaic effect to convert laser beam energy, hold great promise due to their long‐range transmission capability and high precision. However, the current energy conversion efficiency of these systems requires further improvement to achieve optimal performance. To enhance concentrated photovoltaic (CPV) system performance, the study examines different nonimaging concentrators such as reverse truncated pyramid, cross‐compound parabolic concentrator, and square elliptical hyperboloid. Numerical simulations using the finite element method analyze the multifield coupling mechanism of PV modules with various concentration lenses. Three CPV systems with RTP concentrators of different heights were studied to understand the impact of geometry on CPV performance. And the main impact of rotation angle was discussed. The research findings provide essential insights into CPV system performance and the influence of different concentration lenses, contributing valuable knowledge towards improving LWPT technologies.
Copper Oxide Nanoparticles Anchored on Porous Carbon Nitride Nanosheets for Supercapacitor Applications
Authors: Merum Dhananjaya , Pitcheri Rosaiah , Roy Nipa , Kilari Naveen Kumar , Tighezza Ammar Mohamed , Roy Soumyendu , Joo Sang Woo
Published: May 2024

Electrochemical energy storage devices are vital for renewable energy integration and the deployment of electric vehicles. Ongoing research seeks to create new materials with innovative morphologies capable of delivering high specific capacitance for the next generation of customizable energy devices. Carbon nitride is an excellent candidate for electrochemical energy storage devices; however, it has limitations such as layer stacking, poor electric conductivity, a restricted number of electroactive sites, and static electrochemical reaction rates. This research objective is to make porous structures in carbon nitride nanosheets and integrate them with CuO particles to increase surface area and improve electrochemical performance. The use of thermal heating, acidic treatment, and hydrothermal processes accomplishes this. Along with X‐ray diffraction peaks of the CuO phase, a prominent peak (002) at 27.67° indicates the presence of graphitic‐structured carbon nitride. TEM images show that CuO particles are evenly attached to the surface of g‐C3N4 nanosheets with lattice intervals of 0.336 and 0.232 nm, which are the (002) and (111) orientations of the g‐C3N4 and CuO phases, respectively. Adding CuO nanoparticles to porous g‐C3N4 nanosheets avoids layer stacking and provides micro‐ and mesopore channels, increasing the specific surface area (42.60 m2 g-1). The CuO@ porous g‐C3N4 electrode delivered 817 F g-1 of specific capacitance at 1 A g-1 and admirable capacitance retention (92.3% after 6000 cycles) due to the synergistic impact of its unique composition and structural characteristics. Because of its outstanding electrochemical performance and fascinating discoveries, CuO@ porous g‐C3N4 may be employed as a cathode material for high‐performance supercapacitors.
The Rare Large Common Peroneal Nerve’s Schwannoma—A Case Report and Literature Review
Authors: Harahap Rudiansyah , Harahap Nurmaliannysa Dwinandia
Published: May 2024

Schwannoma in the popliteal fossa is still rare, often diagnosed late because it grows slowly and has no symptoms. It is often misdiagnosed with connective tissue tumors or with neurological disorders originating in the spine or disorders of the peroneal nerve. Schwannoma within the common peroneal nerve is still rare in the popliteal fossa, with most tumor sizes around 2 cm in diameter due to their smaller size of nerve but can cause neurologic disturbance, especially when it is large. And over a long time, it can cause serious complaints like neurological deficits and make surgery difficult by leaving greater sequelae. There is no data yet showing the incidence of schwannoma in the common peroneal nerve. In this case, a 36-year-old woman, for 5 years, feels soreness in the popliteal fossa and pain in the right instep, suspected that a nerve was pinched, due to an abnormality in the spine. As time went on, there was a lump in the fold of the right knee, suspected to be a Baker’s cyst. As time went by, the complaint was burning pain in the right instep to the lateral ankle and distal right lower leg, disturbing sleep. Tinel’s sign was positive. The right instep has hypoesthesia and a slight drop in the foot. On radiological examination of the right knee, a circumferential mass appeared, measuring 5 cm×4 cm. The diagnosis is suspicious for a common peroneal nerve tumor. The encapsulated operation to remove the tumor was carried out with a size measuring 5 cm×4.5 cm×4 cm. The histopathological examination showed schwannoma. After surgery, the pain disappeared, hypoesthesia and a slight drop in the foot underwent physiotherapy, and stimulation with the result gradually improved. A thorough early examination includes correct and systematic anamnesis, physical examination, and neurological evaluation such as paraesthesia, hypoesthesia, and Tinel’s sign; also, additional examinations, such as radiographic, ultrasound, and MRI, are needed for early detection of schwannoma so that delays in diagnosis and surgery can be avoided to prevent neurological deficits.
Supplementary Table S1-S5 from Chromoplexy Is a Frequent Early Clonal Event in EWSR1-Rearranged Round Cell Sarcomas That Can Be Detected Using Clinically Validated Targeted Sequencing Panels
Authors: Dermawan Josephine K. , Slotkin Emily , Tap William D. , Meyers Paul , Wexler Leonard , Healey John , Vanoli Fabio , Vanderbilt Chad M. , Antonescu Cristina R.
Published: May 2024

Supplementary Tables S1-S3. List of chromoplectic structural variants, including chromosomal coordinates, event type, and annotated genes/genomic regions, in cases with EWSR1::FLI1 (Table S1), EWSR1::ERG (Table S2), EWSR1::WT1 (Table S3) driver fusions, and longitudinal/sequencing samples from patients with EWSR1::FLI1 or EWSR1::WT1 driver fusions.
Supplementary Figures and Tables from Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors
Authors: Magrath Justin W. , Sampath Shruthi Sanjitha , Flinchum Dane A. , Hartono Alifiani B. , Goldberg Ilon N. , Boehling Julia R. , Savkovic Suzana D. , Lee Sean B.
Published: May 2024

Supplementary Figures and Tables
Supplementary Data 2 from Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors
Authors: Magrath Justin W. , Sampath Shruthi Sanjitha , Flinchum Dane A. , Hartono Alifiani B. , Goldberg Ilon N. , Boehling Julia R. , Savkovic Suzana D. , Lee Sean B.
Published: May 2024

EWSR1::WT1 Downregulated Pathways
Supplementary Table S1 from Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer
Authors: Gedik Mustafa Emre , Saatci Ozge , Oberholtzer Nathaniel , Uner Meral , Akbulut Caliskan Ozge , Cetin Metin , Aras Mertkaya , Ibis Kubra , Caliskan Burcu , Banoglu Erden , Wiemann Stefan , Üner Ayşegül , Aksoy Sercan , Mehrotra Shikhar , Sahin Ozgur
Published: May 2024

This file contains Supplementary Table S1
Table S9 from Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations
Authors: Park Seung-Jin , Ju Shinyeong , Goh Sung-Ho , Yoon Byoung-Ha , Park Jong-Lyul , Kim Jeong-Hwan , Lee Seonjeong , Lee Sang-Jin , Kwon Yumi , Lee Wonyeop , Park Kyung Chan , Lee Geon Kook , Park Seog Yun , Kim Sunshin , Kim Seon-Young , Han Ji-Youn , Lee Cheolju
Published: May 2024

Table S9
Supplementary Table S8. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

Summary of proteins that interact with MILIP in MDA-MB-231 cells detected using mass spectrometry.
Supplementary Table S7. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

The top 10 changed gene sets in MDA-MB-231 cells caused by MILIP knockdown.
Supplementary Table S6. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

Summary of clinicopathological characteristics of the cohort of 60 mutant p53 TNBC patients.
Table S6 from Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations
Authors: Park Seung-Jin , Ju Shinyeong , Goh Sung-Ho , Yoon Byoung-Ha , Park Jong-Lyul , Kim Jeong-Hwan , Lee Seonjeong , Lee Sang-Jin , Kwon Yumi , Lee Wonyeop , Park Kyung Chan , Lee Geon Kook , Park Seog Yun , Kim Sunshin , Kim Seon-Young , Han Ji-Youn , Lee Cheolju
Published: May 2024

Table S6
Supplementary Table S5. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

List of primers, probes and adaptors.
Table S5 from Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations
Authors: Park Seung-Jin , Ju Shinyeong , Goh Sung-Ho , Yoon Byoung-Ha , Park Jong-Lyul , Kim Jeong-Hwan , Lee Seonjeong , Lee Sang-Jin , Kwon Yumi , Lee Wonyeop , Park Kyung Chan , Lee Geon Kook , Park Seog Yun , Kim Sunshin , Kim Seon-Young , Han Ji-Youn , Lee Cheolju
Published: May 2024

Table S5
Supplementary Table S3. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

List of reagents.
Supplementary Fig. S7. from MILIP Binding to tRNAs Promotes Protein Synthesis to Drive Triple-Negative Breast Cancer
Authors: Zheng Si Min , Feng Yu Chen , Zhu Qin , Li Ruo Qi , Yan Qian Qian , Teng Liu , Yue Yi Meng , Han Man Man , Ye Kaihong , Zhang Sheng Nan , Qi Teng Fei , Tang Cai Xia , Zhao Xiao Hong , Zhang Yuan Yuan , Xu Liang , Xu Ran , Xing Jun , Baker Mark , Liu Tao , Thorne Rick F. , Jin Lei , Preiss Thomas , Zhang Xu Dong , Cang Shundong , Gao Jin Nan
Published: May 2024

Targeting MILIP inhibits TNBC xenograft growth.
Table S14 from Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations
Authors: Park Seung-Jin , Ju Shinyeong , Goh Sung-Ho , Yoon Byoung-Ha , Park Jong-Lyul , Kim Jeong-Hwan , Lee Seonjeong , Lee Sang-Jin , Kwon Yumi , Lee Wonyeop , Park Kyung Chan , Lee Geon Kook , Park Seog Yun , Kim Sunshin , Kim Seon-Young , Han Ji-Youn , Lee Cheolju
Published: May 2024

Table S14
Supplementary Figure 6 from Proteogenomic Characterization Reveals Estrogen Signaling as a Target for Never-Smoker Lung Adenocarcinoma Patients without EGFR or ALK Alterations
Authors: Park Seung-Jin , Ju Shinyeong , Goh Sung-Ho , Yoon Byoung-Ha , Park Jong-Lyul , Kim Jeong-Hwan , Lee Seonjeong , Lee Sang-Jin , Kwon Yumi , Lee Wonyeop , Park Kyung Chan , Lee Geon Kook , Park Seog Yun , Kim Sunshin , Kim Seon-Young , Han Ji-Youn , Lee Cheolju
Published: May 2024

Supplementary Figure 6
Figure S2 from NCI Cancer Research Data Commons: Lessons Learned and Future State
Authors: Kim Erika , Davidsen Tanja , Davis-Dusenbery Brandi N , Baumann Alexander , Maggio Angela , Chen Zhaoyi , Meerzaman Daoud , Casas-Silva Esmeralda , Pot David , Pihl Todd , Otridge John , Shalley Eve , Barnholtz-Sloan Jill S. , Kerlavage Anthony R.
Published: May 2024

CRDC Dataset Citations by Year
Supplementary Table 7 from Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma
Authors: Xiang Handan , Pan Yidan , Sze Marc A. , Wlodarska Marta , Li Ling , van de Mark Karyn Ann , Qamar Haleema , Moure Casey J. , Linn Douglas E. , Hai Josephine , Huo Ying , Clarke James , Tan Tze Guan , Ho Samantha , Teng Karen W. , Ramli Muhammad N. , Nebozhyn Michael , Zhang Chunsheng , Barlow Julianne , Gustafson Corinne E. , Gornisiewicz Savanna , Albertson Thomas P. , Korle Stephanie L. , Bueno Raphael , Moy Lily Y. , Vollmann Elisabeth H. , Chiang Derek Y. , Brandish Philip E. , Loboda Andrey
Published: May 2024

Spearman Correlation Between NOTCH3 Expression and global genes, angiogenesis gene signature, and stroma_EMT_TGFbeta gene signature in TCGA and Collaboration dataset
Supplementary Table 3 from Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma
Authors: Xiang Handan , Pan Yidan , Sze Marc A. , Wlodarska Marta , Li Ling , van de Mark Karyn Ann , Qamar Haleema , Moure Casey J. , Linn Douglas E. , Hai Josephine , Huo Ying , Clarke James , Tan Tze Guan , Ho Samantha , Teng Karen W. , Ramli Muhammad N. , Nebozhyn Michael , Zhang Chunsheng , Barlow Julianne , Gustafson Corinne E. , Gornisiewicz Savanna , Albertson Thomas P. , Korle Stephanie L. , Bueno Raphael , Moy Lily Y. , Vollmann Elisabeth H. , Chiang Derek Y. , Brandish Philip E. , Loboda Andrey
Published: May 2024

ScRNA-seq gene expression of mesenchymal cells
Supplementary Table 2 from Single-Cell Analysis Identifies NOTCH3-Mediated Interactions between Stromal Cells That Promote Microenvironment Remodeling and Invasion in Lung Adenocarcinoma
Authors: Xiang Handan , Pan Yidan , Sze Marc A. , Wlodarska Marta , Li Ling , van de Mark Karyn Ann , Qamar Haleema , Moure Casey J. , Linn Douglas E. , Hai Josephine , Huo Ying , Clarke James , Tan Tze Guan , Ho Samantha , Teng Karen W. , Ramli Muhammad N. , Nebozhyn Michael , Zhang Chunsheng , Barlow Julianne , Gustafson Corinne E. , Gornisiewicz Savanna , Albertson Thomas P. , Korle Stephanie L. , Bueno Raphael , Moy Lily Y. , Vollmann Elisabeth H. , Chiang Derek Y. , Brandish Philip E. , Loboda Andrey
Published: May 2024

The IMC antibody and nuclear staining list
Supplemental Table 2: Pattern 1 Pathways from Transfer Learning Reveals Cancer-Associated Fibroblasts Are Associated with Epithelial–Mesenchymal Transition and Inflammation in Cancer Cells in Pancreatic Ductal Adenocarcinoma
Authors: Guinn Samantha , Kinny-Köster Benedict , Tandurella Joseph A. , Mitchell Jacob T. , Sidiropoulos Dimitrios N. , Loth Melanie , Lyman Melissa R. , Pucsek Alexandra B. , Zabransky Daniel J. , Lee Jae W. , Kartalia Emma , Ramani Mili , Seppälä Toni T. , Cherry Christopher , Suri Reecha , Zlomke Haley , Patel Jignasha , He Jin , Wolfgang Christopher L. , Yu Jun , Zheng Lei , Ryan David P. , Ting David T. , Kimmelman Alec , Gupta Anuj , Danilova Ludmila , Elisseeff Jennifer H. , Wood Laura D. , Stein-O'Brien Genevieve , Kagohara Luciane T. , Jaffee Elizabeth M. , Burkhart Richard A. , Fertig Elana J. , Zimmerman Jacquelyn W.
Published: May 2024

Pattern 1 Pathways
Supplementary Table 4 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

Overview of the interactions at the interface between AXIN1 and β-catenin for the mutated amino acids and their predicted effects.
Supplementary Table 1 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

Primer sequences
Supplementary Figure 9 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

AlphaFold structure prediction for human AXIN1
Supplementary Figure 8 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

β-catenin reporter analysis of AXIN1 R395P and R395H HEK293T knockin clones
Supplementary Figure 6 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

response of β-catenin signaling in HEK293T cells following Wnt3A or GSK3β inhibitor addition
Supplementary Figure 16 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

Strong AXIN1 missense variants induce liver tumor formation in mice
Supplementary Figure 13 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

Addition of an extra RGS/APC domain restores APC and β-catenin binding to selected RGS/APC domain variants, and (partially) restores β-catenin regulation
Supplementary Figure 12 from Analysis of Tumor-Associated AXIN1 Missense Mutations Identifies Variants That Activate β-Catenin Signaling
Authors: Zhang Ruyi , Li Shanshan , Schippers Kelly , Li Yunlong , Eimers Boaz , Lavrijsen Marla , Wang Ling , Cui Guofei , Chen Xin , Peppelenbosch Maikel P. , Lebbink Joyce H.G. , Smits Ron
Published: May 2024

Analysis of additional tumor-associated AXIN1 variants located at conserved residues within the C-terminal part of the Tankyrase domain for their ability to impact β-catenin signaling.
Data from Targeting TACC3 Induces Immunogenic Cell Death and Enhances T-DM1 Response in HER2-Positive Breast Cancer
Authors: Gedik Mustafa Emre , Saatci Ozge , Oberholtzer Nathaniel , Uner Meral , Akbulut Caliskan Ozge , Cetin Metin , Aras Mertkaya , Ibis Kubra , Caliskan Burcu , Banoglu Erden , Wiemann Stefan , Üner Ayşegül , Aksoy Sercan , Mehrotra Shikhar , Sahin Ozgur
Published: May 2024

Abstract
Trastuzumab emtansine (T-DM1) was the first and one of the most successful antibody–drug conjugates (ADC) approved for treating refractory HER2-positive breast cancer. Despite its initial clinical efficacy, resistance is unfortunately common, necessitating approaches to improve response. Here, we found that in sensitive cells, T-DM1 induced spindle assembly checkpoint (SAC)-dependent immunogenic cell death (ICD), an immune-priming form of cell death. The payload of T-DM1 mediated ICD by inducing eIF2α phosphorylation, surface exposure of calreticulin, ATP and HMGB1 release, and secretion of ICD-related cytokines, all of which were lost in resistance. Accordingly, ICD-related gene signatures in pretreatment samples correlated with clinical response to T-DM1–containing therapy, and increased infiltration of antitumor CD8+ T cells in posttreatment samples was correlated with better T-DM1 response. Transforming acidic coiled-coil containing 3 (TACC3) was overexpressed in T-DM1–resistant cells, and T-DM1 responsive patients had reduced TACC3 protein expression whereas nonresponders exhibited increased TACC3 expression during T-DM1 treatment. Notably, genetic or pharmacologic inhibition of TACC3 restored T-DM1–induced SAC activation and induction of ICD markers in vitro. Finally, TACC3 inhibition in vivo elicited ICD in a vaccination assay and potentiated the antitumor efficacy of T-DM1 by inducing dendritic cell maturation and enhancing intratumoral infiltration of cytotoxic T cells. Together, these results illustrate that ICD is a key mechanism of action of T-DM1 that is lost in resistance and that targeting TACC3 can restore T-DM1–mediated ICD and overcome resistance.
Significance:
Loss of induction of immunogenic cell death in response to T-DM1 leads to resistance that can be overcome by targeting TACC3, providing an attractive strategy to improve the efficacy of T-DM1.
Data from NCI Cancer Research Data Commons: Lessons Learned and Future State
Authors: Kim Erika , Davidsen Tanja , Davis-Dusenbery Brandi N , Baumann Alexander , Maggio Angela , Chen Zhaoyi , Meerzaman Daoud , Casas-Silva Esmeralda , Pot David , Pihl Todd , Otridge John , Shalley Eve , Barnholtz-Sloan Jill S. , Kerlavage Anthony R.
Published: May 2024

Abstract
More than ever, scientific progress in cancer research hinges on our ability to combine datasets and extract meaningful interpretations to better understand diseases and ultimately inform the development of better treatments and diagnostic tools. To enable the successful sharing and use of big data, the NCI developed the Cancer Research Data Commons (CRDC), providing access to a large, comprehensive, and expanding collection of cancer data. The CRDC is a cloud-based data science infrastructure that eliminates the need for researchers to download and store large-scale datasets by allowing them to perform analysis where data reside. Over the past 10 years, the CRDC has made significant progress in providing access to data and tools along with training and outreach to support the cancer research community. In this review, we provide an overview of the history and the impact of the CRDC to date, lessons learned, and future plans to further promote data sharing, accessibility, interoperability, and reuse.

See related articles by Brady et al., p. 1384, Wang et al., p. 1388, and Pot et al., p. 1396
Optimization and Local Cost-Effectiveness of Nasopharyngeal Carcinoma Screening Strategies in Southern China: Secondary Analysis of the Guangdong Randomized Trial
Authors: Miller Jacob A. , Liu Zhiwei , Pinsky Benjamin A. , Le Quynh-Thu , Li Tong , Yu Kelly J. , Hildesheim Allan , Cao Su-Mei
Published: May 2024

Background:

Screening with anti-Epstein–Barr virus (EBV) serology and endoscopy decreased nasopharyngeal carcinoma (NPC) mortality in Guangdong in a randomized trial. We conducted a secondary analysis of this trial using local incidence and cost data to optimize screening programs, hypothesizing that screening could be cost-effective in southern China.

Methods:

Screening costs and life-years after NPC diagnosis were obtained from the Guangdong trial’s intent-to-screen population (men and women aged 30–69). Seropositive subjects were rescreened annually for 5 years. Thereafter, we evaluated 12 screening strategies in Guangdong and Guangxi using a validated model. Strategies used combinations of serology, nasopharyngeal swab PCR (NP PCR), endoscopy, and MRI from trial subcohorts. Incidence data and costs were obtained from local cancer registries and the provincial healthcare system.

Results:

In the intent-to-screen population, screening with serology and endoscopy was cost-effective (¥42,366/life-year, 0.52 GDP per capita). Screening for 5 to 15 years between ages 35 and 59 years met a willingness-to-pay threshold of 1.5 GDP/quality-adjusted life-years in all modeled populations. Despite doubling costs, adding MRI could be cost-effective via improved sensitivity. NP PCR triage reduced endoscopy/MRI referrals by 37%. One-lifetime screen could reduce NPC mortality by approximately 20%.

Conclusions:

EBV–based serologic screening for NPC is likely to be cost-effective in southern China. Among seropositive subjects, the preferred strategies use endoscopy alone or selective endoscopy triaged by MRI with or without NP PCR. These data may aid the design of screening programs in this region.

Impact:

These findings support population-based screening in southern China by defining the target population, cost-effectiveness, and optimized screening approach.
Supplementary Table S1 from Enhanced Antipediatric Sarcoma Effect of Everolimus with Secukinumab by Targeting IL17A
Authors: Huang Dan , Wu Zhipeng , Wu Zhengyi , Li Nuoya , Hao Liang , Li Kuangfan , Zeng Junquan , Qiu Bingbing , Zhang Shouhua , Yan Jinlong
Published: May 2024

Supplementary Table S1 shows the DNA primers designed for PCR-based human identification.
Supplementary Figure S2 from Enhanced Antipediatric Sarcoma Effect of Everolimus with Secukinumab by Targeting IL17A
Authors: Huang Dan , Wu Zhipeng , Wu Zhengyi , Li Nuoya , Hao Liang , Li Kuangfan , Zeng Junquan , Qiu Bingbing , Zhang Shouhua , Yan Jinlong
Published: May 2024

Supplementary Figure S2 shows in vivo toxicity evaluation on vital organs of mice in each group performed by HE staining.
Table S5 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Table S5: The metabolites for significant correlation to both PFS and OS in cohort 2.
Supplementary Figure 4 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Authors: Sur Subhayan , Bhartiya Pradeep , Steele Robert , Brennan Michelle , DiPaolo Richard J. , Ray Ratna B.
Published: May 2024

Supplementary Figure 4: A, Volcano plot illustrates the expression of genes in cDC2 populations in the treated group as compared to the control tumors. The x-axis represents log2 -fold change, and the y-axis denotes (−log10) p-value showing statistical significance. The horizontal dashed line is p =0.05 [−log10(0.05) = 1.3], the cut-off threshold. B, Violin plot showing Chil3, Prnp, Slfn4, and Cxcl3 expression in control vs. M-I-treated tumors.
Supplementary Figure Legend from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Supplementary Figure Legend
Supplementary Figure 3 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Authors: Sur Subhayan , Bhartiya Pradeep , Steele Robert , Brennan Michelle , DiPaolo Richard J. , Ray Ratna B.
Published: May 2024

Supplementary Figure 3: A, Violin plots showing the number of genes (top panel) and unique molecular identifier (UMI) (bottom panel) of control and M-I-treated CD45+ cells. B, Number of the genes in each cluster is shown.
Figure S7 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Correlation heatmap in Cohorts 1 and 2. Correlation analysis of metabolites with significant differences between positive and negative polarity modes. Red indicates a positive correlation, blue indicates a negative correlation, and white indicates a nonsignificant correlation. The depth of color is related to the absolute value of the correlation coefficient, that is, the higher the degree of positive or negative correlation, the darker the color. The point size is related to the significance of the correlation: more significant, smaller p values and larger points.
Supplementary Figure 1 from Momordicine-I Suppresses Head and Neck Cancer Growth by Reprogrammimg Immunosuppressive Effect of the Tumor-Infiltrating Macrophages and B Lymphocytes
Authors: Sur Subhayan , Bhartiya Pradeep , Steele Robert , Brennan Michelle , DiPaolo Richard J. , Ray Ratna B.
Published: May 2024

Supplementary Figure 1: MOC2 cells treated with bitter melon extract (BME) or momordicine -I (M-I). Cell number was enumerated by the Trypan blue dye exclusion method after 48 hours of treatment. The results shown are the average of three independent experiments. The small bar indicates the standard error.
Figure S6 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

The proportion of the identified metabolites in each chemical classification in Cohort 1 (A) and Cohort 2 (B). Colors in the figure express different chemical classification attribution entries, and the percentage represents the number of metabolites in the chemical classification entry as a proportion of all identified metabolites. Metabolites without chemical classification attribution were defined as undefined.
Figure S5 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Score plot from OPLS-DA of the two groups in Cohort 1 (A, B) and Cohort 2 (C, D). Each data point represents a function of the entire spectral profile of each subject. Partial least-squares discriminant analysis showed a clear separation between the groups with acceptable goodness of fit. Cross-validation plot with a permutation test repeated 200 times. The intercepts of R2 and Q2 under negative (A, C) and positive (B, D) ion modes illustrate that the OPLS-DA model is not overfitted.
Figure S3 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Total ion chromatograms (TICs) of the sample metabolites of Cohort 1 and Cohort 2 detected by UHPLC under negative (A, C) and positive (B, D) ion modes.
Figure S2 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

Volcano plot of serum metabolomics in Cohorts 1 and 2. The left figures (A, C) were obtained in the negative polarity mode, and the right figures (B, D) were obtained in the positive polarity mode. The abscissa is the log value of log2 of multiple differential expression (fold change), and the ordinate is the log value of -log10 of significant p values. Significant different metabolites: those with an FC> 1.5 and p value <0.05 are shown in rose red, and those with an FC <0.67, and p value <0.05 are colored in blue. Nonsignificantly different metabolites are indicated in black.
Figure S1 from Evaluating for Correlations between Specific Metabolites in Patients Receiving First-Line or Second-Line Immunotherapy for Metastatic or Recurrent NSCLC: An Exploratory Study Based on Two Cohorts
Authors: Xu Yanjun , Ding Kaibo , Peng Zhongsheng , Ding Ling , Li Hui , Fan Yun
Published: May 2024

O-partial least-squares discrimination analysis (OPLS-DA) of metabolites of Cohort 1 and Cohort 2 under negative (A, C) and positive (B, D) ion modes. Identified compounds could be separated well with optimal goodness of fit. Green indicates samples from the long-term survival group; blue indicates samples from the short-term survival group.
Table S1 from A Review of Recent Advances in the Molecular Mechanisms Underlying Brain Metastasis in Lung Cancer
Authors: Guan Chao , Zhang Xiaoye , Yu Li
Published: May 2024

Table S1 shows EGFR co-mutated genes associated with lung cancer BM.
Supplementary Table S1 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Authors: Petersen Mark E. , Brant Michael G. , Lasalle Manuel , Das Samir , Duan Renee , Wong Jodi , Ding Tong , Wu Kaylee J. , Siddappa Dayananda , Fang Chen , Zhang Wen , Wu Alex M. L. , Hirkala-Schaefer Truman , Garnett Graham A. E. , Fung Vincent , Yang Luying , Hernandez Rojas Andrea , Lawn Samuel O. , Barnscher Stuart D. , Rich Jamie R. , Colombo Raffaele
Published: May 2024

Supplementary Table S1 shows the in vitro cytotoxicity of free drugs
Supplementary Figure S4 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Authors: Petersen Mark E. , Brant Michael G. , Lasalle Manuel , Das Samir , Duan Renee , Wong Jodi , Ding Tong , Wu Kaylee J. , Siddappa Dayananda , Fang Chen , Zhang Wen , Wu Alex M. L. , Hirkala-Schaefer Truman , Garnett Graham A. E. , Fung Vincent , Yang Luying , Hernandez Rojas Andrea , Lawn Samuel O. , Barnscher Stuart D. , Rich Jamie R. , Colombo Raffaele
Published: May 2024

Supplementary Figure S4 shows the pharmacokinetic analysis of ADCs (total antibody PK) from the tolerability study in rats
Supplementary Figure S3 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Authors: Petersen Mark E. , Brant Michael G. , Lasalle Manuel , Das Samir , Duan Renee , Wong Jodi , Ding Tong , Wu Kaylee J. , Siddappa Dayananda , Fang Chen , Zhang Wen , Wu Alex M. L. , Hirkala-Schaefer Truman , Garnett Graham A. E. , Fung Vincent , Yang Luying , Hernandez Rojas Andrea , Lawn Samuel O. , Barnscher Stuart D. , Rich Jamie R. , Colombo Raffaele
Published: May 2024

Supplementary Figure S3 shows the in vitro cytotoxicity assessment of trastuzumab-ADCs in both two-dimensional (2D) and three-dimensional (3D) spheroid assays
Supplementary Figure S1 from Design and Evaluation of ZD06519, a Novel Camptothecin Payload for Antibody Drug Conjugates
Authors: Petersen Mark E. , Brant Michael G. , Lasalle Manuel , Das Samir , Duan Renee , Wong Jodi , Ding Tong , Wu Kaylee J. , Siddappa Dayananda , Fang Chen , Zhang Wen , Wu Alex M. L. , Hirkala-Schaefer Truman , Garnett Graham A. E. , Fung Vincent , Yang Luying , Hernandez Rojas Andrea , Lawn Samuel O. , Barnscher Stuart D. , Rich Jamie R. , Colombo Raffaele
Published: May 2024

Supplementary Figure S1 shows the murine plasma stability of T-DL4 and T-DL13
Figure S5 from Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity
Authors: Cornelius Peter , Mayes Benjamin A. , Petersen John S. , Turnquist David J. , Dufour Pierre J. , Dannenberg Andrew J. , Shanahan James M. , Carver Bradley J.
Published: May 2024

This graph displays the exposure-time profile of SDX-7539 in rats after IV administration of SDX-7320 or SDX-7539.
Figure S4 from Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity
Authors: Cornelius Peter , Mayes Benjamin A. , Petersen John S. , Turnquist David J. , Dufour Pierre J. , Dannenberg Andrew J. , Shanahan James M. , Carver Bradley J.
Published: May 2024

These results demonstrate the lack of MetAP1 aminopeptidase inhibition by SDX-7539 and TNP-470, and supports the findings regarding selectivity of these compounds for MetAP2.
Figure S3 from Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity
Authors: Cornelius Peter , Mayes Benjamin A. , Petersen John S. , Turnquist David J. , Dufour Pierre J. , Dannenberg Andrew J. , Shanahan James M. , Carver Bradley J.
Published: May 2024

Compares the 3D crystal structures of MetAP2 with SDX-7539 bound to that of MetAP2 with TNP-470
Figure S1 from Pharmacological Characterization of SDX-7320/Evexomostat: A Novel Methionine Aminopeptidase Type 2 Inhibitor with Anti-tumor and Anti-metastatic Activity
Authors: Cornelius Peter , Mayes Benjamin A. , Petersen John S. , Turnquist David J. , Dufour Pierre J. , Dannenberg Andrew J. , Shanahan James M. , Carver Bradley J.
Published: May 2024

Shows the structures of the PDC, the benzenesulfonate salt form of the physiologically active small molecule, and three test compounds, along with the numbering system utilized for NMR assignment of evexomostat.
Supplementary Legends and Table S1 from The Antipsychotic Drug Penfluridol Inhibits N-Linked Glycoprotein Processing and Enhances T-cell–Mediated Tumor Immunity
Authors: Xu Wenlong , Wang Yuqi , Zhang Na , Lin Xiaofeng , Zhu Di , Shen Cheng , Wang Xiaobo , Li Haiyang , Xue Jinjiang , Yu Qian , Lu Xinyi , Zhou Lu , He Qingli , Tang Zhijun , He Shaodan , Fan Jianjun , Pan Jianbo , Tang Jiangjiang , Jiang Wei , Ye Mingliang , Lu Fanghui , Li Zengxia , Dang Yongjun
Published: May 2024

Supplementary Figure S1-S4
Supplementary Table S1
Supplementary Figure S4 from The Antipsychotic Drug Penfluridol Inhibits N-Linked Glycoprotein Processing and Enhances T-cell–Mediated Tumor Immunity
Authors: Xu Wenlong , Wang Yuqi , Zhang Na , Lin Xiaofeng , Zhu Di , Shen Cheng , Wang Xiaobo , Li Haiyang , Xue Jinjiang , Yu Qian , Lu Xinyi , Zhou Lu , He Qingli , Tang Zhijun , He Shaodan , Fan Jianjun , Pan Jianbo , Tang Jiangjiang , Jiang Wei , Ye Mingliang , Lu Fanghui , Li Zengxia , Dang Yongjun
Published: May 2024

(a) Western blot analysis of protein expression pattern of PD-L1 in HEK293T cells after the exposure to the indicated concentrations of penfluridol for 24 hours.
(b) Protein expression pattern of PD-L1 in B16-F10 cells after treatment with the indicated concentrations of penfluridol for 12 hours as determined by western blot.
(c) The toxicity effect of penfluridol on B16-F10 (top) and B16-OVA (bottom) cells.
(d) Western blot analysis of protein expression of MAN1A1 in B16-OVA cells treated with the indicated siRNA.
Supplementary Figure S1 from The Antipsychotic Drug Penfluridol Inhibits N-Linked Glycoprotein Processing and Enhances T-cell–Mediated Tumor Immunity
Authors: Xu Wenlong , Wang Yuqi , Zhang Na , Lin Xiaofeng , Zhu Di , Shen Cheng , Wang Xiaobo , Li Haiyang , Xue Jinjiang , Yu Qian , Lu Xinyi , Zhou Lu , He Qingli , Tang Zhijun , He Shaodan , Fan Jianjun , Pan Jianbo , Tang Jiangjiang , Jiang Wei , Ye Mingliang , Lu Fanghui , Li Zengxia , Dang Yongjun
Published: May 2024

(a) Western blot analysis of glycoprotein patterns in MDA-MB-231 cells after treatment with the indicated concentrations of penfluridol for 24 hours. Red arrowhead, immature glycoproteins.
(b) Western blot analysis of protein expression pattern of ACE2 in HEK293T cells after treatment with the indicated concentrations of penfluridol for 24 hours.
(c) In HEK293T cells, FLAG-tagged ACE2 was treated for 24 hours, collected by immunoprecipitation, subjected to SDS-PAGE, and analyzed by western blot.
(d) Pearson correlation coefficient of three independent groups of (c) through N-glycan profiling.
Figure S5 from Darolutamide Added to Docetaxel Augments Antitumor Effect in Models of Prostate Cancer through Cell Cycle Arrest at the G1–S Transition
Authors: Buck Stefan A.J. , Van Hemelryk Annelies , de Ridder Corrina , Stuurman Debra , Erkens-Schulze Sigrun , van ’t Geloof Sem , Teubel Wilma J. , Koolen Stijn L.W. , Martens-Uzunova Elena S. , van Royen Martin E. , de Wit Ronald , Mathijssen Ron H.J. , van Weerden Wytske M.
Published: May 2024

Darolutamide suppresses the AR in NMRI nu/nu male mice effectively and safely.
A-B: 16 NMRI nu/nu male mice subcutaneously bearing a PC346C tumor were treated for 14 days with 200 mg/kg darolutamide orally daily (n=4), 100 mg/kg darolutamide orally daily (n=4), were castrated and received vehicle (n=4) or were sham-castrated and received vehicle (n=4). Mean of prostate and seminal vesicle weight with SD is shown. *: p < 0.05; **: p < 0.01.
C: Bodyweight of mice treated with darolutamide was not different from mice treated with vehicle, while bodyweight loss of castrated mice reached up to 5%, before recovery after 14 days.