bluuebunny/crossref_metadata_2025 huggingface dataset:
THE DIFFERENCE BETWEEN THE REPORTS FROM ASTHMATIC CHILDREN AND THEIR PARENTS ABOUT THE EFFECT OF ASTHMA ON THEIR QUALITY OF LIFE IN PEDIATRIC HOSPITAL-BENGHAZI-LIBYA
Authors:   PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya., Amraja Essam , Buras Ali Raja ,   PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya., Elsherif Abdulnaser ,   PharmD, Faculty of Pharmacy, Libyan International Medical University, Benghazi, Libya., SE Hussein Maryam ,   Anesthesia and Emergency Medicine Department, Faculty of medical technology, Benghazi, Libya., Kattab Hwuida ,   Department of Pharmacology and Toxicology, College of Pharmacy, University of Benghazi, Benghazi, Libya.
Published: July 2021

Introduction: Childhood asthma is a serious health problem that results in impairment of physical and social life of the affected children. Objective: The current study identifies the effect of asthma on asthmatic children quality of life and also to assess the differences between childs and parents report about the effect of the asthma on the childs physical health, childs emotional health and childs activity. Method: A cross-sectional, descriptive, quantitative study was carried out where about Sixty-four participants of asthmatic children with their parents that were attached at Pediatric Hospital in Benghazi have been recruited and asked to complete Children of Health Survey for Asthma (CHSA) instruments. Results and Conclusion: The results showed that asthma relatively affects childrens physical health, activities and emotional health. Also, the results showed that there were significant differences in childs and parent report regarding the effect of asthma in childs quality of life.
CLINICAL AND RADIOLOGICAL STUDY OF PULMONARY TUBERCULOSIS IN DIABETES MELLITUS
Authors:   Postgraduate Student, Dept. of Gen. Medicine, Sri Aurobindo Medical College & PG Institute-Indore., Nigam Abhishek , Joshi Prakash ,   Professor Dept. of Gen. Medicine, Sri Aurobindo Medical College & PG Institute-Indore.
Published: July 2021

Background: Tuberculosis is the third most important communicable disease in Egypt follows the schistosomiasis. The association between TB and DM has been known for thousands of years, Although the incidence of TB is declining slowly, the burden of diabetes is increasing very rapidly, many studies have been performed to answer about the effect of type 2 DM in clinical, radiological and the outcome of pulmonary tuberculosis, however there is still a huge gap of knowledge about the synergetic effect of the two diseases. The objective was to study the clinical and radiological profile of pulmonary tuberculosis among patients having diabetes mellitus (DM). Methods: The study was conducted at the department of general medicine, in a SAIMS Hospital. The study included pulmonary tuberculosis (PTB) patients with diabetes mellitus and the patients who were smear positive for pulmonary tuberculosis (control group) who met the criteria to participate in the study after a thorough examination. Informed written consent was obtained from all patients before enrolment.
LES POLITIQUES DE FINANCEMENT DE LINNOVATION AU MAROC - ETAT DES LIEUX ET PERSPECTIVES -
Authors:   Doctorant ÃƒÂ  UniversitÃƒÂ© Mohamed V, FacultÃƒÂ© des Sciences Juridiques ÃƒÂ©conomiques et sociales Souissi-Rabat., Abdelilah Elkhadri , Abdelhak Chaibi ,   Chef de Projet - R&D Maroc.
Published: July 2021

The Morocco has made considerable efforts in order to develop investments in R&D, from public, private sources or through international cooperation. However, the analysis of the funding policy for Research and Innovation in Morocco teaches us that, in addition to the weak presence of the private sector in this area, public policy is exposed to immense constraints, such as the low budget. allocated, the incompatibility of public proceduresÃ¢Â€Â¦ All the more so, the discontinuity and opacity of almost all the funds and programs have prevented any attempt to develop research and innovation in Morocco. These constraints, both economic, institutional and political, lead to recognize the imminent role that large Moroccan companies could play, in terms of financing research and innovation, However, the use of other alternative modes of financing, such capital investment, Business Angels and Crowdfunding constitute a promising choice, faced with the financing problem faced by startups and innovative project leaders in Morocco.
CONFORMITY ASSESSMENT OF TEMPERATURE MEASURING DEVICES USED IN FORENSIC SCIENCE LABORATORIES UNDER ISO/IEC 17025: 2017
Authors:   Istanbul University-Cerrahpasa, Institute of Legal Medicine and Forensic Sciences, Istanbul, Turkey., Hulya Yukseloglu Emel , Arpacik Hakan ,   Istanbul University-Cerrahpasa, Institute of Legal Medicine and Forensic Sciences, Istanbul, Turkey., Yonar FatmaCavus ,   Istanbul University-Cerrahpasa, Institute of Legal Medicine and Forensic Sciences, Istanbul, Turkey., Salkim Islek Dilek ,   Istanbul University-Cerrahpasa, Institute of Legal Medicine and Forensic Sciences, Istanbul, Turkey., Erkan Itir ,   Istanbul YeniYuzyil University, Faculty of Health Sciences, Istanbul, Turkey., Karatas Omer ,   Istanbul University-Cerrahpasa, Institute of Legal Medicine and Forensic Sciences, Istanbul, Turkey., Ozlem Kolusayin Ozar Melek ,   Istanbul University-Cerrahpasa,Cerrahpasa Medical Faculty, Department of Forensic Medicine, Istanbul, Turkey.
Published: July 2021

Calibration is an expectation for quality management systems as well as a need for laboratories. If there is a need to measure the size in the laboratory, there is also a need to determine whether the measuring instrument used there is measuring with the desired accuracy.In our study, the suitability of the digital thermometer, which is one of the devices used in the forensic science laboratory during the examination of the evidence, was examined within the scope of ISO / IEC 17025: 2017 standard.The temperature of the environment is very important during the analysis of the evidence.Therefore, it is important to determine the measurement uncertainty and confidence interval in the thermometer that measures this temperature.For this reason, in our study, the calibration procedures were carried out by selecting the digital thermometer device and using the calibration method compared to the reference.Uncertainty budgets were prepared by calculating the measurement uncertainty parameters one by one. Conformity assessment was made according to the measurement results.
REPONSE A LA FERTILISATION ORGANIQUE ET MINERALE DE DEUX VARIETES DE GOMBO (ABELMOSCHUS ESCULENTUS (L) MOENCH, MALVACEA) A DALOA, COTE DIVOIRE
Authors:   Universite Jean Lorougnon GUEDE, Laboratoire de lAmelioration de la Production Agricole, UFR Agroforesterie., NGuessan Kouame , Manehonon Martine Beugre ,   Universite Jean Lorougnon GUEDE, Laboratoire de lAmelioration de la Production Agricole, UFR Agroforesterie., NDri Jacob Kouassi ,   Universite Jean Lorougnon GUEDE, Laboratoire de lAmelioration de la Production Agricole, UFR Agroforesterie., Kouadio Justin Yatty ,   Universite Jean Lorougnon GUEDE, Laboratoire de lAmelioration de la Production Agricole, UFR Agroforesterie.
Published: July 2021

This study aims to assess the effect of variety and organic and mineral fertilization on the agronomic parameters of okra. The experimental set-up used was a completely randomized en bloc device. The treatments used are : T0 (controls without amendment), T1 (10 t / ha of chicken manure), T2 (10 t / ha of sawdust, T3 (2.5 t / ha of NPK 15-15 fertilizer) -13). The two varieties compared are the improved variety called Clemson spineless and the local variety Koto or Soudais or gombo Baoule. The results obtained showed significant differences between the two varieties as well as differences between the fertilizers used at (p> 0.05). Organic fertilizer made from chicken manure yielded the best results followed by mineral fertilizer and finally sawdust.
AN INVESTIGATION ON THE LEARNING STYLES OF B.ED. TRAINEES
Authors:   Research Scholar, St. Xaviers College of Education (Autonomous) DighaGhat, Patna, Bihar, India., Kausar Tasneem , Topno Ignatius ,   Professor,St. Xaviers College of Education (Autonomous) DighaGhat, Patna, Bihar, India.
Published: July 2021

The present study is an attempt to find the preferred Learning Styles of B.Ed. Trainees and its effect on a set of independent variables based on Gender, Educational Qualifications, Type of Institutions and their Medium of Study. To achieve this aim, the researcher has adopted survey method. The tool used for the data collection was Learning Styles Inventory developed by Dr. Karuna Shankar Misra (2012). Tool was administered to 230 B.Ed. Trainees drawn randomly from three B.Ed. colleges of Patna.The findings indicated that Verbal Constructive Learning Style was found to be more prevalent Learning Style among B.Ed. Trainees. Furthermore, the results show that there is no significant difference between Learning Styles and its dimensions i.e.Enactive Reproducing, Enactive Constructive, Figural Reproducing, Figural Constructive, Verbal Reproducing and Verbal Constructive Learning Styles on the basis of their Gender, Type of Institutions and Medium of Study. Another major finding is that, there is a significant difference between Graduate and Post-Graduate B.Ed. Trainees in their Learning Styles and its dimensions i.e. Figural Reproducing and Figural Constructive Learning Styles. This information is quite useful to the teachers as by understanding the preference of the students for different Learning Styles would aid them in aligning the course delivery in conjunction with students preferred Learning Styles.
THE ROLE AND AUTHORITY OF THE HALAL PRODUCT ASSURANCE IMPLEMENTING AGENCY (BPJPH) ACCORDING TO LAW NUMBER 33 OF 2014
Authors:   Faculty Of Law Universitas Pembangunan NasionalVeteran Jakarta-Indonesia., Djumarno Djoko , Arafah Sinjar Muhammad ,   Doctoral of Law at the Faculty Of Law Veteran National Development University Jakarta-Indonesia.
Published: July 2021

The purpose of this study are to understand the legal protection of the halal product label as the role and authority of the Halal Product Assurance Agency (BPJPH) according to Law No.33 of 2014 and the advantages and disadvantages of Halal Product Guarantee after the enactment of Law No. 11 of 2020 concerning Job Creation which has changed some of the provisions of the JPH Law. That the enactment of Law no. 33 of 2014 concerning Halal Product Guarantee requires all products circulating in Indonesia to be halal certified. The presence of Law Number 11 of 2020 concerning Job Creation which changes some of the provisions in the JPH Law. Namely, Micro, Small and Medium Enterprises can get halal certification for free with an effective registration process. The drawback of the Job Creation Law are that the authority to inspect halal products is no longer monopolized by the Indonesian Ulema Council but also the Halal Product Guarantee Agency, there is the elimination of the halal auditor requirement, Article 4A of the Job Creation Law has the potential to violate consumer protection if it does not have strong derivative rules, and the lack of clarity on the administrative sanctions given along with the types of violations.
PROSTHETIC REHABILITATION OF A MAXILLECTOMY PATIENT WITH A TITANIUM CLOSED HOLLOW BULB OBTURATOR USING LOST WAX BOLUS TECHNIQUE - A CASE REPORT
Authors:   Professor and Head, Dept.Prosthodontics, Govt. Dental College, Thiruvananthapuram, Kerala, India., Kumar. K. Harsha , S. Senbagavalli ,   Junior Resident, Dept. of Prosthodontics, Govt. DentalCollege, Thiruvananthapuram, Kerala, India., Ravichandran R. ,   Professor, Dept. of Prosthodontics, Govt. DentalCollege, Thiruvananthapuram, Kerala, India., V. Nair Vivek ,   Professor , Dept. of Prosthodontics, Govt. Dental College, Thiruvananthapuram, Kerala, India.
Published: July 2021

Maxillary intraoral defects due to surgical resection create an open link between the oral and nasal cavities causing difficulty in deglutition, speech, and an unaesthetic appearance . Maxillary obturator prosthesis is a more frequent treatment modality than surgical reconstruction for maxillectomy in patients suffering from oral cancer. The obturators often become heavy and hence are hollowed out in the defect portion to reduce its weight as a standard practice. This case report describes the prosthetic rehabilitation of a maxillectomy patient with a titanium cast hollow obturator using lost wax bolus technique.
PREDICTOR VARIABLES OF NEONATAL MORTALITY IN VERY-LOW-BIRTH-WEIGHT INFANTS
Authors:   Student of Medicine at the Federal University of Sao Joao del-Rei., Amaral Calixto Cristina , Macedo Marteletto Nathalia ,   Student of Medicine at the Federal University of Sao Joao del-Rei., da Silva Azevedo Leite Priscila ,   Student of Medicine at the Federal University of Sao Joao del-Rei., Sergio Leite Paulo ,   Student of Medicine at the Federal University of Sao Joao del-Rei., Guimaraes Silva Emylle ,   Student of Medicine at the Federal University of Sao Joao del-Rei., Teixeira Passos Giarola Luciane ,   Professor of Statistics at the Federal University of Sao Joao del-Rei., AlvesLamounier Joel ,   Professor of Medicine at the Federal University of Sao Joao del-Rei., Cristina Moreira Damazio Laila ,   Professor of Medicine at the Federal University of Sao Joao del-Rei., Reimol de Andrade Marcia ,   Professor of Medicine at the Federal University of Sao Joao del-Rei.
Published: July 2021

The aim of this study is to investigate the mortality profile in very-low-birth-weight infants, as well as model the association of some variables with neonatal mortality, in order to detect possible preventable causes of death. This retrospective cross-sectional study included a total of 109 Very-Low-Weight-Infants admitted to a Neonatal Intensive Care Unit in a municipality in Minas Gerais, Brazil, between January 2012 and December 2016. The neonates were divided into two groups: death and non-death. Frequency distributions were constructed for the variables maternal age, sex, birth weight, gestational age, type of delivery, asphyxia (Apgar at five minutes), administration of antenatal corticosteroids, hypothermia, twinning, and amniotic membrane rupture. The survival curve was plotted using the Kaplan-Meier non-parametric estimator, and theassociation between death and the observed explanatory variables was modeled via Logistic Regression. In the survivor group, most infants exhibited normothermia and weight â‰¥1,000g. As for the death group, weight below 1,000g and hypothermic infants were predominant. In both groups, maternal age between 18 and 35 years prevailed, as well as the male sex, gestational age of 224 days, cesarean delivery, and fifth minute Apgar scores â‰¥7. The survival rate, estimated using the Kaplan-Meier method, showed a decrease from 1.0 to 0.55 at the beginning of the observation period. The adjusted logistic regression model included fetal weight and the fifth minute Apgar score. No significant relationship was found between death and the variables type of delivery, hypothermia, and antenatal corticosteroid use.Logistic regression indicated a high probability of death associated with birth weight and the Apgar score at five minutes. The low association with the other variables may be related to the good quality of prenatal, intrapartum, and postpartum care provided in the region and the analyzed hospital.
EXPLORING DIMENSIONS OF IMPULSIVITY IN PATIENTS WITH PERSONALITY DISORDER DURING THE PERIOD OF CONFINEMENT
Authors:   University Psychiatric Hospital Arrazi in Sale, Faculty of Medicine and Pharmacy in Rabat, Mohammed V University, Rabat- Morocco., Karara A. , Benzahra S. ,   University Psychiatric Hospital Arrazi in Sale, Faculty of Medicine and Pharmacy in Rabat, Mohammed V University, Rabat- Morocco., Nafiaa H. ,   University Psychiatric Hospital Arrazi in Sale, Faculty of Medicine and Pharmacy in Rabat, Mohammed V University, Rabat- Morocco., Ouanass A. ,   University Psychiatric Hospital Arrazi in Sale, Faculty of Medicine and Pharmacy in Rabat, Mohammed V University, Rabat- Morocco.
Published: July 2021

Objective:The objective of this work is to describe the sociodemographic and clinical characteristics and to explore the dimensions of impulsivity in patients with personality disorders and to evaluate their evolution during the period of confinement. Methods:This study included a sample of 60 patients followed in ambulatory consultation at the university psychiatric hospital Arrazi inSalÃ©with a personality disorder. The description of the sociodemographic and clinical characteristics was carried out using a questionnaire. The exploration of the dimensions of impulsivity was carried out based on the BarrattImpulsiveness scale. Results: The average age of our patients was 28.3 years, most of the patients were male (75%). In our sample, 61.7% had a substance use disorder, 38.3% had a depressive comorbidity. Concerning the impulsivity context, borderline personality disorder was found in 78.3% of our patients, antisocial personality disorder was found in 21.7%. According to the scores obtained on the Barratt Impulsiveness scale, the three dimensions measured were high in all our patients. Conclusion: Confinement is a mode of adaptation of daily life in crisis situations that has dramatically changed the habits of millions of people throughout the world. It is necessary to underline the great vulnerability of people with a personality disorder to this situation which could expose to a weakening of their psychic state.
GOJIHWADI KWATH- A DRUG REVIEW
Authors:   PG Scholar, Assistant Professor, Professor and H.O.D., Panchola Priyanka , A Deepshikha ,   Department of Kaumarbhritya, UAU, Gurukul campus, Haridwar, Uttarakhand, India., Garg G.P ,   Department of Kaumarbhritya, UAU, Gurukul campus, Haridwar, Uttarakhand, India.
Published: July 2021

Gojihwadi Yoga is described in the 20thcentury textbook â€˜SiddhayogaSangraha written by AcharyaYadavji Trikamji one of the illustrious of Ayurveda of modern era. It is described in Jwara rog Adhikara. In Ayurveda it is an excellent combination of16 ingredients which have bronchodilators, mucolytic, anti-inflammatory and expectorants properties like, Draksha, Yashtimadhu, Vasa, Kantakari, Mishreya, Maricha etc. are described in the ancient classics of Ayurveda. Many of the others like Unnav, Khatmi, Khubkalam, Jufa and Gulbanafsa are the contributions of Unani system of medicine. The indication of Gojihwadi kwath as per Ayurveda isJwara, Kasa and Pratishyaya. According to the author it is suitable in respiratory infections where sputum is thick and adhesive in nature and difficult to come out. This article reviews Ayurvedic and chemical properties of this combination.It can be used without any side effects.
SOME ISSUES OF LEGAL REGULATION OF THE INSTITUTION OF SETTING THE CONTENT OF FOREIGN LAW (BASED ON UZBEKISTAN LEGISLATION)
Authors:   PhD researcher at Tashkent State University of Law,Uzbekistan, Tashkent., Zholdasova Shakhnoza
Published: July 2021

This article analyzes some theoretical and practical issues of setting the content of foreign law. In accordance with the analysis conducted, the author considers that further improvementof the national law of the Republic of Uzbekistan in respect of application and setting the content of foreign lawwould be expedient. In particular, the author suggests that the Civil Procedural Code of the Republic of Uzbekistan should be supplemented with relevant norms, with considerationofadoptionof the separate Law On Private International Law.
DOES CARDIAC TROPONINÂ€“I IS RECOGNIZED AS AN EARLY POSTOPERATIVE MARKER FOR MYOCARDIAL DAMAGE IN CHILDREN?
Authors:   Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah. Saudi Arabia., H. Sharfi Masroor , H. Mashali Mohamed ,   Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah. Saudi Arabia.,   Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo Egypt., Helal Abdelmonem ,   Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah. Saudi Arabia.,   Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo Egypt., A. Al-Shehri Abdullah ,   Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah. Saudi Arabia., Abdelaziz Osama ,   Department of Pediatrics Cardiology, Kasr Alainy Faculty of Medicine, Cairo University, Cairo Egypt., Hadi Al-Ghamdi Abdul ,   Department of Pediatric, King Faisal Specialist Hospital & Research Center, Jeddah. Saudi Arabia.
Published: July 2021

Introduction:Cardiac troponin-I being a sensitive marker of myocardial damage needs to be analyzed in children undergoing cardiopulmonary by-pass surgery, as perioperative myocardial damage may be a significant factor of postoperative cardiac performance. The present study aims to test the prognostic value of Cardiac troponin-I concerning the early postoperative course after pediatric cardiac surgery. Methods:Cardiac troponin â€“ I levels were measured and correlated with intra and postoperative parameters of thirty-three children undergoing open-heart surgery. The cutoff point for the definition of a high and a low-risk group of Cardiac troponin-I values was set at 25 ng/ml. Results:Overall, cTnI peak value was higher than 25 ng/ml in 21 patients among these,4 died, and two of them were reported with the value of >100 ng/ml. 38.7% of the patients were complicated by different types of arrhythmias. Junctional ectopic tachycardia was the most common type of arrhythmia,while heart block complication was found only in one case, which was temporarily treated by pacing for less than 24 hours. The results showed significant correlation of troponin I values with dobutamine dose mg/kg (p-value=0.043), dobutamine duration (p-value=0.020), creatinine (p-value= 0.002), and internalcare unit stay (p-value= 0.003). Conclusion: The present study confirms that troponin I is specific and sensitive marker of myocardial injury after pediatric cardiac surgery.
INCREASING THE EFFICIENCY OF THE USE OF PUBLIC FINANCIAL RESOURCES IN ENSURING EMPLOYMENT OF THE POPULATION
Authors:   Doctorate Student of the Academy of Public Administration under the President of the Republic of Uzbekistan., Nigora Radjabovna Abduraimova
Published: July 2021

The paper reveals the essence of the system of public financial management (PFM), defines its key elements of the PFM system, and articulates goals and objectives in enhancing employment. The authors definition of PFM is given. A comparative analysis of managerial financial cycles in the public and private sectors of the economy is carried out. The historical aspect of the PFM reforms is also analyzed, and various approaches to financial management (income and expenditure) in the public sector are studied and suggested better ways to improve the busyness of the population. Factors influencing the effectiveness of the PFM reforms are revealed. The challenges faced by financial managers in implementing public finance reforms are analyzed, and the opportunities that can be used to achieve the objectives of the PFM system, some of which are simultaneously challenges are analyzed.
PRISE EN CHARGE DES FEMMES ENCEINTES DIABETIQUES A LHOPITAL MATERNITE SANTE DE REPRODUCTION LES ORANGERS EN 2020
Authors:   HMSRO- Universite Mohammed V- Rabat., Ouzaa A. , Jeraf N. ,   HMSRO- Universite Mohammed V- Rabat., Driouech A. ,   HMSRO- Universite Mohammed V- Rabat., Erhaymini K. ,   HMSRO- Universite Mohammed V- Rabat., Ouakasse S. ,   HMSRO- Universite Mohammed V- Rabat., Allelou F. ,   HMSRO- Universite Mohammed V- Rabat., Kabba Z. ,   HMSRO- Universite Mohammed V- Rabat., Chanaa I. ,   HMSRO- Universite Mohammed V- Rabat., Tazi Z. ,   HMSRO- Universite Mohammed V- Rabat., Filali A. ,   HMSRO- Universite Mohammed V- Rabat., Chraibi C. ,   HMSRO- Universite Mohammed V- Rabat., Alami M.H. ,   HMSRO- Universite Mohammed V- Rabat., Bezad R. ,   HMSRO- Universite Mohammed V- Rabat.
Published: July 2021

La grossesse represente encore, pour les femmes diabetiques tout comme pour les equipes soignantes un defi, sa programmation permet la conception dans des meilleurs conditions, en permettant le depistage des complications du diabete et deviter les anomalies fÅ“tales. La surveillance est assuree par une equipe multidisciplinaire avant, pendant et apres la grossesse, sans omettre limportance de lallaitement. Le diabete gestationnel est defini par lADA (American Diabetes Association) et par lOMS comme tout degre dintolerance glucidique ayant debute ou ayant ete mis en evidence pour la premiere fois durant la grossesse. Nous rapportons lexperience de lHÃ´pital Maternite Sante de Reproduction les Orangers a propos de 353 nouveaux cas colliges sur une annee du 1er Janvier au 31 Decembre 2020. 26 % des patientes ont necessite une hospitalisation. Lequilibre glycemique a ete obtenu chez 73% des cas par un regime seul, et 27 % des cas ont necessite de linsulinotherapie. Le moyen de suivi du diabete gestationnel est lauto-surveillance glycemique avec comme objectif une Gaj < 0,95 g/l et Gpp â‰¤ 1,20g/l. La prise en charge de la grossesse diabetique permet de reduire les risques des complications degeneratives du diabete (retinopathie, nephropathie) ainsi que le risque de complications perinatales (anomalies fÅ“tales severes, macrosomie, dystocie des epaules, prematurite).
INTOLERANCE OF UNCERTAINTY AND FEAR OF COVID-19 IN EARLY ADULTS IN KOLKATA
Authors:   M.Phil Clinical Psychology, 1st year, Calcutta University., Ghosh Shinjan
Published: July 2021

The present research has been done to study Intolerance of Uncertainty and Fear of COVID-19 in Early Adults in Kolkata. In this study 25 males and 25 females of the age range, 18 years to 25 years residing in Kolkata has been selected and their data has been collected through online forms. The tools used in this study are Intolerance of Uncertainty Scale- Short Form and Fear of COVID-19 scale. The data has been analyzed through SPSS and Pearsons Product Moment Correlation and the Independent Sample t-test has been done for data analysis. The findings are suggestive of the absence of a significant relationship between Intolerance of Uncertainty and Fear of COVID-19 and the presence of a significant gender difference in the case of Intolerance of Uncertainty.
ROLE OF IVERMECTIN, DOXYCYCLINE ALONG WITH SUPPORTIVE CARE IN TREATMENT OF COVID-19 POSITIVE CHILDREN (>9 YEAR) AND ADOLESCENT AGE GROUP A PROSPECTIVE OBSERVATIONAL STUDY FROM TERTIARY CARE CENTER OF WESTERN U.P
Authors:   Resident, Department of Pediatrics, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh., Singh Nidhi , Goel Yogesh ,   Professor, Department of Pediatrics, Saraswathi Institute of Medical Sciences, Hapur , Uttar Pradesh., Agarwal Ritu ,   Professor, Head of Department, Pediatrics, Saraswathi Institute of Medical Sciences, Hapur, Uttar Pradesh.
Published: July 2021

Background: In December 2019, the infection caused by 2019 novel coronavirus led to an outbreak in Wuhan, situated in the Hubei Province of China. The number of studies on children with COVID-19 is limited. We reviewed that COVID-19 does indeed affect children the same way as any other age group. Children can act as carriers of the virus and can endanger the lives of other individuals. Aim: In this Prospective study a combination of Ivermectin, Doxycycline along with supportive care was evaluated therapeutically to treat COVID-19 children (> 9 year) and adolescent age group. Method: Study was performed on pediatric COVID-19 patient who were enrolled in this study with a predefined inclusion and exclusion criteria. RT- PCR of the SERS-CoV-2 was done. The clinical features and response to treatment were noted according to protocol. Patients were divided in 2 groups.Combination of Ivermectin, Doxycycline and supportive treatment were given in one group and other group acted as control. Retesting was done between 5 to 25 days of starting medication. Result: In the study after excluding 50 patients, out of remaining 110 patients, males and females were 67 and 43 respectively, the age ranged between 9-18 years (Mean age was 10.88 Ã‚Â± 2.39 year). Retesting was done between 5 to 25 days of starting medication. Symptomatic improvement was noticed after 2-3 days of starting medication. Mean recovery time in Ivermectin-Doxycycline-supportive care group (Group B) was 10.28Ã‚Â±4.72 versus 14.92Ã‚Â±8.40 in control group. Hence, using Ivermectin along with Doxycycline reduced mean time to recovery up to 4.64 days. By analyzing the mean time to recovery in mild, moderate and severe patients in each group, it was shown that the mean time to recovery in Group B was 6.88Ã‚Â±1.84,11.78Ã‚Â±1.81, 21.28Ã‚Â±1.79 days, respectively vs 8.375Ã‚Â±1.25, 12.76Ã‚Â±1.73, 23.16Ã‚Â±1.47 days respectively in Group A. All patients symptomatically improved and tested negative. No death was noted in either group. Conclusion: Most of the cases of SARS-CoV-2 were mild and did not require specific treatment but combination of Ivermectin and Doxycycline along with supportive care was found to be effective in early viral clearance and helped the patients to overcome the disease early. Early improvement of symptoms and early discharge were noted in patients whom we gave combination of medicines. Over all it is a very cheap combination, save a lot of lives, and very helpful for resource-poor settings. This study has limitations as our number of patients was small.
The Transformation of Radical Movement in Yogyakarta post-2019 Presidential Election
Authors: Hergianasari Putri , Netanyahu Kurniawan
Published: July 2021

Radical movements colored the 2019 Elections, especially the dichotomy of the Jokowi and Prabowo camps. This phenomenon also occurs among the people of Yogyakarta after the 2019 Presidential Election. The research aims to map the transformation of fundamentalist groups in Yogyakarta after the 2019 Presidential Election. The significant analysis was carried out to provide sources of information to the public and government regarding the transformation of Hizbut Tahrir Indonesia (HTI) after the 2019 Presidential Election. The researchers used qualitative descriptive methods with the analysis of the theory of social resource mobilization. The research results showed that the transformation of the radical movement that formerly took the anarchist forms and down to the streets, now is more focused and organized by entering the community through religious education and recitation groups, both in universities and at household meetings. This research concludes that in order not to be parallel to HTI, which the government dissolved, the transformation of tranquility is one way to maintain the existence of radical organizations but in a more friendly framework or guise. All of these resource mobilization movements take the form of informal social networks.
Rates of Cranial Computed Tomography before and during the COVID-19 Restrictions in Turkey
Authors: ATALAY Başak , GÜNDÜZ Nesrin , AŞIK Murat
Published: July 2021

Aim: In this study, we aimed to compare the admission and examination data of patients who presented to our emergency department with neurological symptoms in April 2019 (before) and April 2020 (during the COVID-19 pandemic).Methods: The study included patients who underwent cranial computed tomography (CT), including patients who additionally underwent CT angiography for suspected stroke. Thus, the study sample consisted of a total of 960 patients, of whom 676 (Group) presented before the COVID-19 pandemic and 284 (Group II) during the course of the pandemic. The data were reviewed retrospectively.Results: The rates of the indications for cranial CT did not statistically significantly (p=0.143) differ between Group I and II: suspected stroke, 76.2% vs. 72.9%; trauma, 22.5% vs. 23.6%; and tumors 1.3% vs. 3.5%, respectively. The rate of finding vessel obstruction on CT angiography was significantly (p<0.05) higher in Group II (25% vs. 65%). The rate of confirmed cases of stroke was significantly (p<0.001) higher in Group II (6.7% vs. 18.7%). Also, the rates of ischemic and hemorrhagic stroke were both significantly higher in Group II (p<0.001 and p=0.043, respectively).Conclusion: While measures for the prevention of the spread of COVID-19 infection have led to a decrease in hospital admissions, a conspicuous increase was observed in the rate of patients with stroke during the same period of time.
Urban Rainwater Harvesting Assessment in Sulaimani Heights District, Sulaimani City, KRG, Iraq
Authors: Gharib Kani Namiq , Mustafa Nawbahar Faraj , Rashid Haveen Muhammed
Published: July 2021

Rainwater harvesting is the collection of rainwater and runoff from catchment areas such as roofs or other urban surfaces. Collected water has productive end-uses such as irrigation, industry, domestic, and can recharge groundwater. Sulaimani heights have been selected as a study area, which is located in Sulaimani Governorate in Kurdistan Region, North Iraq. The main objective of this study was to estimate the amount of harvested rainwater form Sulaimani heights urban area in Sulaimani City. Three methods for runoff calculation have been compared, the storm water management model (SWMM), the soil conservation service (SCS) method, and the runoff coefficient (RC) using daily rainfall data from 1991 to 2019. The annual harvested runoff results with the three different methods SWMM, SCS, and RC were estimated as 836,470 m3, 508,454 m3, and 737,381 m3, respectively. The results showed that SWMM method has the highest runoff result and could meet 31% of the total demand of the study area and 28% and 19% for RC and SCS methods, respectively.
Implementation of Digital Monitoring Services During the COVID-19 Pandemic for Patients With Chronic Diseases: Design Science Approach
Authors: Lapão Luís Velez , Peyroteo Mariana , Maia Melanie , Seixas Jorge , Gregório João , Mira da Silva Miguel , Heleno Bruno , Correia Jorge César
Published: July 2021

Background

The COVID-19 pandemic is straining health systems and disrupting the delivery of health care services, in particular, for older adults and people with chronic conditions, who are particularly vulnerable to COVID-19 infection.

Objective

The aim of this project was to support primary health care provision with a digital health platform that will allow primary care physicians and nurses to remotely manage the care of patients with chronic diseases or COVID-19 infections.

Methods

For the rapid design and implementation of a digital platform to support primary health care services, we followed the Design Science implementation framework: (1) problem identification and motivation, (2) definition of the objectives aligned with goal-oriented care, (3) artefact design and development based on Scrum, (4) solution demonstration, (5) evaluation, and (6) communication.

Results

The digital platform was developed for the specific objectives of the project and successfully piloted in 3 primary health care centers in the Lisbon Health Region. Health professionals (n=53) were able to remotely manage their first patients safely and thoroughly, with high degrees of satisfaction.

Conclusions

Although still in the first steps of implementation, its positive uptake, by both health care providers and patients, is a promising result. There were several limitations including the low number of participating health care units. Further research is planned to deploy the platform to many more primary health care centers and evaluate the impact on patient’s health related outcomes.
The Role of Moral Reasoning on the Effects of Incentive Schemes and Working Relationships on Whistleblowing: An Audit Experimental Study
Authors: Supriyadi Supriyadi , Prasetyaningsih Nidaul Uswah
Published: July 2021

This study examines the role of moral reasoning in strengthening the working relationship and incentive schemes on the likelihood of reporting accounting fraud. This study predicts that higher moral reasoning or being exposed to incentive schemes are more likely to cause someone to be a whistleblower. However, individuals with a close working relationship with wrongdoers will exhibit a lower propensity to blow the whistle than those with no close working relationship. Finally, moral reasoning is expected to interact with working relationships and incentive schemes to affect the propensity to blow the whistle. Based on a lab-experiment with 147 participants, this study documents that the simple effect of moral reasoning, the working relationship, or an incentive scheme is (marginally) significant. Similarly, the combination of moral reasoning and the working relationship significantly improves the tendency to blow the whistle. However, the combined effects of moral reasoning vs. the working relationship and moral reasoning vs. the working relationship vs. incentive scheme are not significant. This paper confirms previous studies which found that moral reasoning significantly alters the whistleblowing intention but that the impact of moral reasoning is not robust for incentive schemes and working relationships. Some limitations should be considered, namely the textual scenarios of the experimental design, working experiences, and the omission of personal orientation and the personal cost of reporting.
SYNTHESIS AND CHARACTERIZATION OF BOC-PROTECTED THIO-1,3,4-OXADIAZOL-2-YL DERIVATIVES
Authors: SHAFI S. SYED , RAJESH R. , SENTHILKUMAR S.
Published: July 2021

Objective: The objective of this work is to synthesis thio-1,3,4-oxadiazol-2-yl derivatives for industrial applications.
Methods: The synthesis was done by the reaction of (S)-2-amino-2-phenylacetic acid with ethanol-derived ethyl (S)-2-amino-2-phenylacetate. The reaction of ethyl (S)-2-amino-2-phenylacetate with Boc anhydride and hydrazine produces ethyl (S)-2-((tert-butoxycarbonyl)amino)-2-phenylacetate. The intermediate 5-alkyl amino-1,3,4-oxadiazole-2-thiols have been isolated as stable compounds.
Results: To study the characteristics of these compounds, they are subjected to 1HNMR, 13CNMR, and IR. These studies examine the chemical structure of synthesized compounds. The mass of the novel compounds was established with the help of the LCMS test. The structural and optical properties were examined by the powder XRD and photoluminescence spectrum respectively.
Conclusion: The sharp intense peak in the powder XRD indicates the crystal nature of the sample. The values obtained from the LCMS test indicate that the compounds have good thermal stability. The absorption peak at 358 nm in the PL spectrum indicates that the sample can be used in photoelectronic devices.
DEVELOPMENT AND VALIDATION OF STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF ETHINYL ESTRADIOL AND GESTODENE IN BULK AND PHARMACEUTICAL DOSAGE FORMS
Authors: SUCHITRA D. , SATYANARAYANA BATTU
Published: July 2021

Objective: The principal objective of this study is to develop and validate a simple, new, fast, selective, precise, and economic stability-indicating the RP-HPLC method for the simultaneous estimation of Ethinyl estradiol and Gestodene in a bulk and pharmaceutical dosage form.

Methods: The present method was developed and validated on a Waters HPLC system using Phenomenex Gemini C18(250 mm × 4.6 mm i.d., 5 µm particle size) column and mobile phase composition of phosphate buffer: Acetonitrile (75:25 v/v) and the pH was adjusted to 3.6 using dilute orthophosphoric acid. The system was regulated at 1.0 ml/min flow rate at 237 nm UV detection.

Results: The two drugs Ethinyl Estradiol and Gestodene, were eluted at 1.788 min and 3.475 min retention time, respectively. The analytical parameters such as accuracy, precision, linearity, LOD, LOQ, ruggedness, and robustness were used for validating the developed method according to International Conference on Harmonisation [ICH] guidelines. Linearity was exhibited over the concentration range of 10-50µg/ml and 25-125µg/ml for Ethinyl Estradiol and Gestodene, respectively. The method revealed the Limit of Detection and Quantitation values for Ethinyl Estradiol and Gestodene were 1.399µg/ml, 3.909µg/ml and 4.24µg/ml, 11.85µg/ml, respectively. The stress testing was carried out to give rise to degradation products by exposing the drugs to acid, alkali, thermal, oxidative, photolytic, and hydrolytic degradation. The obtained data showed that the content of Active pharmaceutical ingredients and the degradation products were successfully separated without any interference, which confirmed the stability-indicating nature of the developed method.

Conclusion: The new, simple, rapid, selective, precise, and economic stability-indicating RP-HPLC method has been successfully developed and validated. It can be satisfactorily applied for the periodic laboratory quantitative estimation of Ethinyl Estradiol and Gestodene in formulations and active pharmaceutical ingredients.
EVALUATION OF THE INDIAN TOP 10 PHARMA EDUCATION INSTITUTIONS RESEARCH OUTPUT LISTED BY NATIONAL INSTITUTIONAL RANKING FRAMEWORK (NIRF) 2020: A SCIENTOMETRIC STUDY
Authors: KAPPI MALLIKARJUN , S. MADHU , BIRADAR BALABHIM SANKRAPPA
Published: July 2021

The Higher Education System Rankings measure national higher education systems and meet a long-standing need to shift the discussion from the ranking of the NIRF top institutions to the best overall systems in each country, to reflect the country’s overall performance in NIRF rankings we propose a new Excellence/Quality indicator based on the excellence level reached by their Top Pharma education institutions within the Top positions of the NIRF weighted by the country’s size population. In the present study, we analyzed the Top 10 Pharma education institutions of the NIRF Ranking 2020. The first rank positioned by Hamdard University NIRF score of (80.5). SCOPUS database was used to extract the data and the study was limited to five years (2016-2019) which resulted in 7172 documents. The data analysis was performed using Biblioshiny, Microsoft excel, and VOS Viewer software, further data were explored using the bibliometrics tools and techniques. The study attempt to measure the top 10 Pharma Education Institution’s and their publications, Year-Wise distribution of research Output, document type, Highly Prolific Authors, Most Preferred Sources, Funding Agencies, Most Cited Papers, Most Productive and Most Cited Countries, and Highly Prolific Keywords based on the collected data. The analysis of the study indicates the highest publications with 2129, published by Institute of Chemical Technology-Mumbai; the most the productive year 2017 with 1508 publications; most of the publications are published as articles (6067); highly prolific author Sekar N with 194 papers, total citation 1954, h-index 22; preferred source title RSC Advance, 217 paper, total citation 2508, h-index 24; top funding agency University Grant Commission (UGC) 609 papers; top cited paper Shao Y, 2015, Molecular Physics; most productive and most cited country the USA.
ASSESSMENT OF BIOLOGY ACTIVITY OF THE PEELING SUBSTANCES BY THE PHYSICOCHEMICAL APPROACHES ON THE SPIROSTOMUM AMBIGUUM CELL MODEL
Authors: E. V. USPENSKAYA , T. V. PLETENEVA , HANH PHAM MY , I. V. KAZIMOVA
Published: July 2021

Objective: To evaluate the biological activity of chemical peeling substances based on enzymatic and Arrhenius kinetics using Spirostomum ambiguum as an alternative approach to animal experiments.

Methods: The Spirotox method was used to analyze the mechanism of «xenobiotic-cell» interaction, similar to the Michaelis-Menten enzymatic kinetics. The Hill-Langmuir equation was used to determine the degree of cooperativity in the binding of xenobiotics to cellular receptors. Using the Arrhenius kinetics, the observed activation energy obsEa of cell death in the model solutions of glycolic and carbolic acids was determed, which will allow predicting the toxicity parameters of any peeling substances.

Results: The relationship Spirostomum ambiguum lifetime tL-lgC concentration of peeling compound solution made it possible to characterize the moment of cellular transition from the intermediate state C•Ln to the dead state DC, characterized by irreversible structural and functional changes in the cell/death. The values were 5.3 mmol•l-1 for glycolic acid solutions and 2.8 mmol•l-1 for carbolic acid solutions. Equilibrium constants Keq of complexation, the rate of infusoria death fm, and the degree of ligand cooperativity n were calculated. The activation energy °bsEa of cell death was determined in Arrhenius coordinates, which were 210±0.39 kJ·mol-1 and 108±0.09 kJ·mol-1 for glycolic and carbolic acids respectively. The correlation between the values ​​of activation energy and DL50 of mammals (rats) was discovered.

Conclusion: The obtained kinetic parameters made it possible, without animals and humans testing, to characterize the mechanisms of interaction of peeling substances with the living cell.
AN INVESTIGATION OF THE ANALGESIC AND ANTI-INFLAMMATORY EFFECTS OF AERIAL PARTS OF FLACOURTIA JANGOMAS
Authors: JOTHIMANIVANNAN C. , LALITHA P. , MEENA K. , MEENAJESILIYA A. , MOGANAPRIYA J. C. , MANIMEKALAI P.
Published: July 2021

Objective: The present study was aimed to evaluate the analgesic and anti-inflammatory effects of leaf and stem part aqueous extract of Flacourtia jangomas.

Methods: Aqueous extract of leaves (ALE) and aqueous extract stem (ASE) part of Flacourtia jangomas were sequentially prepared by maceration process and subjected to a preliminary phytochemical screening. The anti-inflammatory activity was assessed by the carrageenan-induced acute rat paw oedema model and Analgesic activity was evaluated by acetic acid-induced writhing model and hot plate method in mice. The data were analysed by one-way ANOVA followed by post hoc Dunnet’s test by using SPSS V.15 (student trail version).

Results: The preliminary phytochemical analysis of extracts of leaves and stems indicated the presence of carbohydrate, alkaloids flavonoids, phenols, tannins, saponins. The extracts showed significant anti-inflammatory and analgesic activities with a dose-dependent manner. The ethanolic extract from the leave extract of Flacourtia jangomas at the dose 200 mg/kg has 55.6% significant anti-inflammatory activity compared to the standard drugs (44.4%). Even at the low dose leave extract has more potent than aqueous stem extract. Where in analgesic effect by Hot plate method basal reaction time results showed that aqueous extract of stem part at the dose of 200 mg /kg has a significant effect at 120 mts 10.0 sec when compared with std pentazocine 13.0 sec. In peripheral analgesic method Acetic acid-induced writhing model results have not shown much more significant when compared with standard drug (42.1%). The potential to cause anti-inflammation by stem extract was comparatively less than that of leave extract. Thus it could be concluded that Flacourtia jangomas leave extract possess significant anti-inflammatory activity

Conclusion: Our findings suggest that Flacourtia jangomas extract is safe and has potential anti-inflammatory and analgesic activities, which promote this use as a food supplement against pain and inflammation related to inflammatory diseases.