bluuebunny/crossref_metadata_2025 huggingface dataset:
Peripheral Blood Smear Atypical Lymphocytes Association With Covid-19 Mortality
Authors: Nazir Imran , TA Gamal Ebid , Khalil Khalid , Imran Iffat , Almatrafi Mohammed A , Muddassir Rabia , Al Mutairi Bader , Abouelregal Tarek Elsayed
Published: February 2023

Introduction: COVID-19 disease is currently pandemic, and its prevalence in Saudi Arabia is concerning. The SARS-CoV-2 virus primarily affects the lungs, but it also affects the haematopoietic system. The atypical lymphocytes on peripheral blood film that have a distinct morphological appearance were of particular interest in this study. Our goal was to see a link between atypical lymphocytes and COVID-19 patient mortality. Methods: This four-month single-centered prospective descriptive study was conducted in Makkah, Saudi Arabia. COVID-19 patients of both genders were randomly selected based on inclusion criteria. The data from the patient’s electronic medical record was extracted. All patients’ peripheral blood film parameters were recorded on days 3, 7, and 14 after admission. The statistical data was analysed using SPSS version 23. The Fisher’s exact test was used to determine the relationship with mortality. A p value of 0.05 was considered significant. Results: The total number of cases enrolled in the study was 226. The patients’ average age was 58 years (SD 0.5289). On the third day of admission, 88.2 % of patients with COVID-19 had atypical lymphocytes, with a mean of 2.35 ± 0.927. A significant correlation (p < 0.001) exists between atypical lymphocytes decreasing percentage number on the 3rd, 7th, and 14th days of admission and death.
Conclusion: The decrease in the number of atypical lymphocytes on peripheral blood film has a significant association with the patients’ mortality. This fact can be used to develop a tailored management strategy based on the observation of peripheral blood film.
Exploring Dimensional Structure of Intimate Co-creation: An Exploratory Factor Analysis
Authors: Shahzad Muhammad Umar , Ishaque Amir
Published: February 2023

Different forms of value co-creation have been a source of literary debate in management literature. Management scholars got the early inspiration for this phenomenon of multi-stakeholder engagement from the field of design engineering in the 1970s. Intimate co-creation is a new concept that explores the immediate impact that a co-creation activity might have on an individual at the dyadic, group, or team level. Most of its benefits as conceptually theorized by Rouse (2020) are very positive; however, it lacks a valid measurement scale for which an exploratory analysis of the dimensional structure of intimate co-creation is needed. The current study has addressed the same research gap. For this purpose, a mixed methods study was conducted to explore the dimensional structure of intimate co-creation and operationalize the concept for development of relevant items. This exploratory factor analysis is the prime step in a series of studies to develop a new measurement scale on intimate co-creation.
High Enrichment of Heavy Metals in Fine Particulate Matter through Dust Aerosol Generation
Authors: Gao Qianqian , Zhu Shengqiang , Zhou Kaili , Zhai Jinghao , Chen Shaodong , Wang Qihuang , Wang Shurong , Han Jin , Lu Xiaohui , Chen Hong , Zhang Liwu , Wang Lin , Wang Zimeng , Yang Xin , Ying Qi , Zhang Hongliang , Chen Jianmin , Wang Xiaofei
Published: February 2023

Abstract. Dust is a major source of atmospheric aerosols. Its chemical composition is often assumed to be similar to the parent soil. However, this assumption has not been rigorously verified. Here, we generated dust aerosols from soils to determine if there is particle size-dependent selectivity of heavy metals in the dust generation. Mn, Cd, Pb and other heavy metals were found to be highly enriched in fine (PM2.5) dust aerosols, which can be up to ~6.5-fold. To calculate the contributions of dust to atmospheric heavy metals, regional air quality models usually use the dust chemical profiles from the US EPA’s SPECIATE database, which does not capture the correct size-dependent selectivity of heavy metals in dust aerosols. Our air quality modeling for China demonstrates that the calculated contribution of fine dust aerosols to atmospheric heavy metals, as well as their cancer risks, could have significant errors without using proper dust profiles.
Greenhouse gas effects on the solar cycle response of water vapour and noctilucent clouds
Authors: Vellalassery Ashique , Baumgarten Gerd , Grygalashvyly Mykhaylo , Lübken Franz-Josef
Published: February 2023

Abstract. The response of water vapour (H2O) and noctilucent clouds (NLCs) to the solar cycle are studied using the Leibniz Institute for Middle Atmosphere (LIMA) model and the Mesospheric Ice Microphysics And tranSport (MIMAS) model. NLCs are sensitive to the solar cycle because their formation depends on background temperature and the H2O concentration. The solar cycle affects the H2O concentration in the upper mesosphere mainly in two ways: directly through the photolysis and, in time and place of NLCs formation, indirectly through temperature changes. We found that H2O concentration correlate positively with the temperature changes due to the solar cycle at altitudes above about 82 km, where NLCs form. The photolysis effect leads to an anti-correlation of H2O concentration and solar Lyman-α radiation, which gets even more pronounced at altitudes below ~83 km when NLCs are present. We studied the H2O response to Lyman-α variability for the period 1992 to 2018, including the two most recent solar cycles. The amplitude of Lyman-α variation decreased by about 40 % in the period 2005 to 2018 compared to the preceding solar cycle, resulting in a lower H2O response in the late period. We investigated the effect of increasing greenhouse gases (GHGs) on the H2O response throughout the solar cycle by performing model runs with and without increases in carbon dioxide (CO2) and methane (CH4). The increase of methane and carbon dioxide amplify the response of water vapour to the solar variability. The solar cycle response is reduced in the late solar cycle due to a smaller amplitude of Lyman-α variability in the second period. Applying the geometry of satellite observations, we find a missing response when averaging over altitudes of 80 to 85 km, where H2O has a positive and a negative response (depending on altitude) which largely cancel out. One main finding is that during NLCs the solar cycle response of H2O strongly depends on altitude. A negative correlation between H2O and Lyman-α is found in the NLC sublimation zone below an altitude of about 83 km, but a positive response is present at the altitudes above 83 km where NLCs form.
Temporary stratification promotes large greenhouse gas emissions in a shallow eutrophic lake
Authors: Davidson Thomas Alexander , Søndergaard Martin , Audet Joachim , Levi Eti , Esposito Chiara , Nielsen Anders
Published: February 2023

Abstract. Shallow lakes and ponds undergo frequent temporary thermal stratification. How this affects greenhouse gas (GHG) emissions is moot, with both increased and reduced GHG emissions hypothesised. Here, weekly estimation of GHG emissions were combined with high-resolution temperature and oxygen profiles of an 11 hectare shallow lake to investigate how thermal stratification shapes GHG emissions. There were three main stratification periods with profound anoxia in the bottom waters occurring quickly upon isolation from the atmosphere. Average diffusive emission of methane (CH4) and nitrous oxide (N2O) were larger and more variable in stratified phase, whereas carbon dioxide (CO2) was on average lower. CH4 ebullition was an order of magnitude greater in the stratified phase. In addition, there was a large efflux of CH4 and CO2 when the lake mixed after periods of extended (circa 14 days) thermal stratification. These two turnover events were estimated to have released the majority of the CH4 emitted between May and September. These results highlight the role of turnover emissions resulting from temporary thermal stratification and also the need high frequency measurements of GHG emission in order to accurately characterise emissions from these temporarily stratifying lakes.
Atmospheric oxidation of new 'green' solvents part II: methyl pivalate and pinacolone
Authors: Mapelli Caterina , Donnelly James K. , Hogan Úna E. , Rickard Andrew R. , Robinson Abbie T. , Byrne Fergal , McElroy Con Rob , Curchod Basile F. E. , Hollas Daniel , Dillon Terry J.
Published: February 2023

Abstract. Lab-based experimental and computational methods were used to study the atmospheric degradation of two promising “green” solvents: pinacolone, (CH3)3CC(O)CH3 and methyl pivalate, (CH3)3CC(O)OCH3. Pulsed laser photolysis coupled to pulsed laser induced fluorescence was used to determine absolute rate coefficients (in 10−12 cm3 molecule−1 s−1) of k1(297 K) = (1.2 ± 0.2) for OH + (CH3)3CC(O)CH3 (R1) and k2(297 K) = (1.3 ± 0.3) for OH + (CH3)3CC(O)OCH3 (R2), in good agreement with one previous experimental study. Rate coefficients for both reactions were found to increase at elevated temperature, with k1(T) adequately described by k1(297 – 485 K) = 2.1 × 10−12 exp(−200/T) cm3 molecule−1 s−1. k2(T) exhibited more complex behaviour, with a local minimum at around 300 K. In the course of this work, k3(295 – 450 K) for the well-characterised reaction OH + C2H5OH (ethanol, R3) were obtained, in satisfactory agreement with the evaluated literature. UV-vis. spectroscopy experiments and computational calculations were used to explore (CH3)3CC(O)CH3 photolysis (R4). Absorption cross sections for (CH3)3CC(O)CH3, σ4(λ) in the actinic region were larger and the maximum was red-shifted compared to estimates used in current state-of-science models. As a consequence, we note that photolysis (R4) is likely the dominant pathway for removal of (CH3)3CC(O)CH3 from the troposphere. Nonetheless, large uncertainties remain as quantum yields ϕ4(λ) remain unmeasured. Lifetime estimates based upon (R1) and (R4) span the range 2–9 days and are consequently associated with a poorly constrained Photochemical Ozone Creation Potential estimate (POCPE). In accord with previous studies, (CH3)3CC(O)CH3 did not absorb in the actinic region, allowing for straightforward calculation of an atmospheric lifetime of ≈ 9 days and a small POCPE ≈ 11.
Making a makerspace: Reimagining makerspaces for women's participation
Authors:   , Capel Tara
Published: February 2023

This thesis investigated how makerspaces can be designed in more inclusive ways to promote participation by women. It identified three core qualities – appropriate labelling, the configuration of learning, and turning ambitions into an artefact - that foster women’s participation and growth into confident and competent makers. This thesis also demonstrates how the configuration of new spaces, which facilitate engagement with new tools and materials, can lead to new areas of design, allowing new opportunities for self-expression, dialogue and reflection between participants, participants and researchers, and participants and the items they create.
A Communicological critique of evaluative norms for digital preservation success
Authors:   , Abrams Stephen
Published: February 2023

This thesis examines the adequacy of existing measures of success for the long-term preservation of the of electronic content that plays such a central role in all aspects of contemporary life. It finds the concept of success poorly defined in theory and inadequately supported in practice by libraries, archives, museums, datacenters, and repositories. In response, this work outlines a new approach for evaluating success that complements the objective measure of preservation management with the subjective assessment of individual human experience when using preserved resources as vehicles for technically-mediated communication across time.
التسويق الإلكتروني وأثره على الحصة السوقية (دراسة نظرية تحليلية)
Authors:   ماجستير في إدارة الأعمال، كلية إدارة الأعمال، جامعة لينكولن، ماليزيا, الراكان عبد الرحمن , غوش ابهيجيت ,   دكتوراه في إدارة الأعمال، كلية إدارة الأعمال، جامعة لينكولن، ماليزيا, شمسي محمد ,   دكتوراه في إدارة الأعمال، جامعة بورغوني، ديجون، فرنسا
Published: February 2023

يهدف البحث الحالي إلى إظهار أثر استخدام المنظمة للتسويق الإلكتروني على حصتها السوقية حيث تم تلخيص مشكلة البحث من خلال الإجابة على السؤال الرئيسي: هل هناك أثر للتسويق الإلكتروني على الحصة السوقية للمنظمة وقد اعتمد البحث الحالي على استخدام المنهج الوصفي القائم على مراجعة عدد من الأدبيات السابقة (عربية وأجنبية)، حيث تم شرح مفهوم التسويق الإلكتروني من حيث أهميته وأهدافه وأساليبه وايضاح إيجابياته وسلبياته، ومن ثم شرح مفهوم الحصة السوقية وأهميتها والعوامل المؤثرة عليها ومؤشرات قياسها، وقد خلص البحث إلى مجموعة من النتائج كان من أبرزها تزداد فرص امتلاك المنظمة لحصة سوقية أكبر حينما تقوم بالتركيز على كسب ثقة عدد أكبر من العملاء والمستثمرين ممن يستخدمون منتجاتها وخدماتها، وذلك يصبح أكثر سهولة وفعالية حينما يتم الاعتماد على أساليب التسويق الإلكتروني التي تنشر المعلومات والمواصفات بدقة وبأسلوب جاذب للانتباه، مما يدعم توجهات المنظمة في تمديد نطاق معاملاتها السوقية بصدد امتلاك حصة سوقية أكبر. ووفقًا لما تم التوصل إليه من نتائج، تمكن الباحث من عرض مجموعة من المقترحات التي يوصي بتطبيقها أهمها: تطوير كفاءات ومهارات المختصين التسويقيين لكي يقوموا بتطويع خبراتهم التسويقية بأساليب التسويق الإلكتروني واستخدام تطبيقات تكنولوجيا الاتصالات والمعلومات بفعالية، ضرورة تشجيع الحكومات لاعتماد المنظمات على التسويق الإلكتروني، كوسيلة لدعم رؤى الدول بصدد تحولها الرقمي على نحو شامل، تطوير المنظمة لبنيتها التحتية التكنولوجية، من خلال الاعتماد على أجهزة متطورة، وأنظمة تشغيل حديثة، تعيين مجموعة من الخبراء في البرمجة لإكساب المختصين التسويقيين خبرة كافية في كيفية إنشاء الأكواد التي تعمل على تحسين آليات البحث عن العلامة التجارية للمنظمة، وظهورها في أوائل صفحات النتائج على محركات البحث المختلفة.
Direct Listings and the Tracing Doctrine: Why Congress or the SEC Must Intervene
Authors: Kapoor Neal
Published: February 2023

In September 2021, the U.S. Court of Appeals for the Ninth Circuit in Pirani v. Slack Technologies became the first circuit to have a say on whether an investor who purchases securities in a direct listing can establish standing to bring claims under Section 11 of the Securities Act of 1933. The Ninth Circuit’s controversial ruling challenges fifty years of established jurisprudence and has the potential to deter companies from performing direct listings. This Note argues for Congress or the SEC to intervene by requiring or encouraging companies to adopt blockchain technology once they go public via a direct listing. The goal of this approach is to ensure that companies continue to use direct listings, while also preserving adequate investor protections.
Reviews of Flight Attendants towards the Tourism Program: Case of the Lyceum of the Philippines University
Authors: Paguinto Krisca Mae A. , Rosarito Ziryl F. , Lamanilao Ma. Theresa L. , Salvador Allyssa Marey R. , Dellova Rovena
Published: February 2023

This study looked into the recommendations and views of Filipino flight attendants on the level of importance of the courses, their training experiences, and recommendations that serve as a window to consider the improvement of the tourism program. This descriptive study utilized a post-hoc analysis of version 2.0 with 72 respondents currently or formerly employed as flight attendants. They constitute 50% of the population proportion of 140 identified Filipino flight attendants from different airlines, both international and local, having 11.50% precision at a .05 significance level. A purposive type of sampling method mixed with the snowball technique was utilized in this study. In-Flight Attendant program offering, the study reveals that minor courses were rated as “highly important” specifically in Communication subjects while major courses were rated “very highly important”. Among the 29 listed major courses, Risk Management as Applied to Safety, Security, and Sanitation ranked first, followed by Global Culture and Tourism Geography, followed by Professional Development and Applied Ethics. Moreover, most of the respondents faced challenges over inadequate knowledge of aircraft equipment and emergency procedures. It is highly recommended by some of the current Filipino flight attendants to enhance and/or add courses/activities related to Basic Life Support, Personality Development, Communication Skills Development, Customer Service, and Aircraft-related courses.
Bicycle as a New Tourism Trend and Transportation in the New Normal
Authors: Dellova Rovena , Bigoy Erica R. , Jogno John Jeffrey G. , Joson Ella Jane S. , Monterola Mark Ardrin , Santos Sophia Jamela T.
Published: February 2023

Bicycle tourism is booming in the tourism market and exists as a means of transportation in hundreds of cities around the world. However, in the Philippines, it was only popularized after the COVID-19 pandemic caused a transportation crisis and a massive decline in tourism growth. This qualitative study determines bicyclists’ perceptions, identified bicycling problems encountered, and explores bicycling opportunities in the new normal. The study utilized a phenomenological research design with data from virtual interviews with 10 bicyclists in Metro Manila. They were identified using purposive sampling and data saturation. The findings revealed that bicycle tourism is perceived as a sustainable activity that can promote and boost a destination’s local tourism. Meanwhile, using the bicycle as means of transportation is perceived as an efficient, affordable, and sustainable mode of active transportation and provides health benefits. It was also found to bring economic opportunities like job employment and became a catalyst for bicycle- related businesses to arise. Researchers concluded that bicycling would increase with these opportunities, This will pave the way for recovery, resulting in more sustainable tourism and transportation industry in the Philippines.
Frustrated Magnetism: A Case Study of Geometric Frustration
Authors: Moses Amos
Published: February 2023

In this research work, frustrations arising from the geometries of triangular lattices have been studied with the aid of Ising and Heisenberg models. The study reveals that geometrical frustrations can generate multiple degeneracies in the ground state. The quantum spin flip terms in the Heisenberg model are observed to play a vital role in the partial lifting up of these degeneracies. Hence, multiple degeneracies as consequence of frustrations are more pronounced for the Ising systems, which are devoid of quantum fluctuations. The observed six- and four-fold ground state degeneracies at zero field for three spins Ising and Heisenberg systems respectively are broken down to half at finite longitudinal fields. For this three-spin system, quantum phase transitions (QPT) are observed at critical longitudinal fields of J and 1.5J respectively for the Ising and Heisenberg models. At these critical fields, the ground states are observed to shift from quasi-antiferromagnet to ferromagnet. However, for the Heisenberg three-spin system in the presence of a transverse field, no transition is observed.
Synthesis and characterization of silver doped calcium chromate spinel Nano- particles and Ca effect on its band gap and optical properties
Authors: Akram Mariam , Batool Kiran , Musadik Sara , Shafique Rubia , Sidika Aisha , Kamran Muhamad , Rabab Zahira
Published: February 2023

Silver chromates catalysts have newly been discussed by different preparation and utilization approaches. The results of all discussion explain that silver chromates is a proficient catalyst using for catalyses programmes at national and commercial level including worldwide environmental control of pollution. Various applications of silver chromates in energy clean, laboratory. Eco-friendly approach naming sol-gel is used to get final sample and characterized by SEM, XRD, EDS and photoluminescence. Final sample approach is affected by various parameters. Furnance was used to sinter at 750-900 o C for 4 hours.I intended 1.56 eV band gap value, 28.881 nm crystalline size for doped sample and EDS describes silver was successfully doped and emerged completely.
An Exploratory Multi-Case Study of the Health and Wellbeing Needs, Relationships and Experiences of Health and Social Care Service Users and the People who Support them at Home
Authors: Henderson Louise , Bain Heather , Allan Elaine , Kennedy Catriona
Published: February 2023

Introduction: International policies and legislation set a precedence of person-centred sustainable integrated Health and Social Care (HSC) that meets the health and wellbeing needs of service users through improved experiences. However, current research focuses on service models, with fewer studies investigating experiences and needs.Methods: This qualitative multi-case [n = 7] study was co-designed with key stakeholders and aimed to explore experiences and needs of people who access and provide HSC at home. Data were collected in a regional area of Scotland (UK) via single [n = 10] or dyad [n = 4] semi-structured interviews with service users [n = 6], informal carers [n = 5] and HSC staff [n = 7] and synthesised using Interpretive Thematic Analysis.Findings: Interpersonal connections and supportive relationships were instrumental in helping all participant groups feel able to cope with their changing HSC needs and roles. They promoted reassurance, information sharing and reduced anxiety; when they were lacking, it negatively impacted upon experiences of HSC.Discussion: Promoting inter-personal connections that encourage supportive relationships between people who access and provide HSC and their communities, could promote person-centred Relationship-based care and improve HSC experiences.Conclusions: This study identifies indicators for improved HSC, advocating co-produced community-driven services to meet the self-defined needs of those who access and provide care.
Biyolojik Yöntemle Üretilmiş Gümüş Nanopartiküllerin In Vitro Koşullarda Digitalis purpurea Kallus ve Kök Oluşumları Üzerine Etkilerinin İncelenmesi
Authors: NARTOP Pınar , YÜKSEL Özge Nur , ŞENCAN Dilara Özge
Published: February 2023

Gümüş nanopartikülleri teknolojinin farklı alanlarında sıklıkla kullanılmaktadırlar. Biyosistemler üzerinde de önemli ve faydalı etkileri bulunmaktadır. Ancak, etkileri yeterli derecede çalışılmamıştır. Biyo-AgNP’lerin in vitro koşullardaki bitki dokularının ve hücrelerinin gelişimi üzerinde arttırıcı etkileri bulunmaktadır. Bu sebeple, yüksek fiyatlı bitki büyüme düzenleyicilerine alternatif olarak kullanılabilirler. Bu çalışmanın amacı, Digitalis purpurea gövde eksplantlarında farklı konsantrasyonlardaki (0-30 mg/L) biyo-AgNP’lerin etkilerini incelemektir. Bu amaçla, kallus ve kök oluşumları ve eksplant kararmaları izlenmiştir. Biyo-AgNP’lerin kallus oluşumuna etkisi olumsuzdur. 1 mg/L biyo-AgNP içeren besin ortamı hariç, kallus oluşum yüzdelerinin hepsi kontrol grubundan daha azdır. Kök oluşum yüzdeleri, 15 ve 20 mg/L biyo-AgNP içeren besin ortamlarında (sırasıyla %42.22 ve %46.67) kontrole göre (%35.56) daha yüksek bulunmuştur. Kallus oluşumlarının tersine, kök oluşumları kararmadan olumsuz etkilenmemiştir. Bu sonuçlar in vitro koşullarda hücre çoğalması ve doku rejenerasyonunun biyo-AgNP’lerden ve onların konsantrasyon yoğunluğundan farklı şekilde etkilendiğini göstermektedir.
The Effect of Phase Change Temperature of Graphite Matrix Composite on Small-Scale Li-Ion Package Performance Under Square Wave Load
Authors: YAZICI Mustafa Yusuf
Published: February 2023

An experimental study is performed to illustrate the effect of the melting temperature of graphite matrix composite with phase change materials on the performance characteristics of a small-scale li-ion package (3s2p) under dynamic/square wave load. Paraffin (RT35 and RT42) is used as a PCM. Graphite matrix is manufactured with 75 g l-1 bulk density. The battery package is performed for three different configurations: free-air cooling case (reference case), and graphite matrix composites with RT35 and RT42. The experimental outputs present that graphite matrix composite has considerable potential for thermal management of the Li-ion pack. Safe operating time, discharge and energy capacity values are increased by 140%, 141% and 102% with the graphite composite with RT35 in the comparison reference case, respectively. It is observed that the melting temperature of PCM of graphite composite is of critical importance to the performance of the battery pack. For the graphite composite with RT35, operating time, discharge capacity and energy capacity values are enhanced by 6.2 %, 7 % and 10 % compared to the RT42 case, respectively.
Türkiye’de Konut Sorununun Toplu Konut Olgusu Üzerinden Dönemsel Olarak İncelenmesi
Authors: GÜLEN Mustafa
Published: February 2023

Konut, insanın beşerî gereksinimleri (barınma, uyuma, yeme, içme vb.) ile sosyal ve psikolojik ihtiyaçlarına cevap veren fonksiyonel hacimleri barındırır. Bu sebeple tarih boyunca her çağda insanların en önemli sorunlarından birisi olarak süregelmiştir. Mimarlık pratiğinin de en temel araştırma konularından birisi olan konut, XIX. ve XX. yüzyıldan bu yana hem gelişmiş birçok ülkede hem de Türkiye’de önemli tartışma başlıklarından birisidir. Çünkü bu yüzyıllar ile birlikte konutun üretim biçimi değişmiştir. Tekil olarak, kişilere özgü üretilen konutların toplumsal, ekonomik ve siyasal dinamiklerle birlikte kitlesel olarak üretilmeye başlandığı izlenmektedir. Dünyada Endüstri Devrimi ile işçilerin barınma problemini çözmeye yönelik başlayan toplu konut inşa etme süreci günümüzde hala başvurulan önemli konut üretim modellerinden birisidir. Türkiye’de günden güne artan nüfusun barınma gereksinimi, yüksek kira bedelleri, kent çeperlerinde artış gösteren imara aykırı, plansız yapılaşmalar konut sorununun varlığını gösteren önemli emareler olarak yorumlanmaktadır. Geç Osmanlı Dönemi’nden 2000’li yıllara kadar geçen süreçte her 20-30 yılda bir farklı konut politikaları yürütülerek uygulamaya geçirilmiştir. 2000’li yıllardan sonra ise Türkiye’deki konut sorununun çözümünde toplu konut üretimi önemli bir rol oynamakta; toplu barınma kültürü de nüfusun hızla arttığı ve hızlı büyüyen kentlerde yaygınlaşmaktadır. Bu çalışmada Türkiye’deki konut sorunu toplu konut olgusu üzerinden kronolojik bir şekilde Geç Osmanlıdan başlayarak günümüze kadar dönemsel olarak derlenmiştir. Çalışmada ayrıca bir asırlık süreçte toplu konut uygulamalarının kapsamı, hedefi ve bu süreçlerde yer alan aktörlerin rolleri üzerinde durulmuştur.
LISINOPRIL AN OVERVIEW
Authors: Ghanshyam Pund Mr. Lalit , V. Sonaye Ms. Harsha , Doifode Dr. C.A. , Nitin S
Published: February 2023

Lisinopril is an oral long-acting angiotensin converting enzyme inhibitor. It is a lysinederivative of Enalprilate and has structural similarity with its substrate. It differs from captopril by lacking the sulfhydryl group [1,2]. Lisinopril is chemically described as (S)-1-[N2-(1carboxy-3-phenylpropyl)-L-lysyl]-Lproline dihydrate. Its empirical formula is C21H31N3O5.2H2O.The present study was aimed at developing a simple, sensitive, precise and accurate HPLC method for the estimation of Lisinopril from bulk samples and tablet dosage forms. A non-polar C8 analytical chromatographic column was chosen as the stationary phase for the separation and determination of Lisinopril. Mixtures of commonly used solvents like water, methanol and acetonitrile with or without buffers in different combinations were tested as mobile phases. The choice of the optimum composition is based on the chromatographic response factor, a good peak shape with minimum tailing. A mixture of buffer and methanol in the ratio of 35:65 v/v was proved to be the most suitable of all the combinations since the chromatographic peak obtained was well defined, better resolved and almost free from tailing. The retention time of Lisinopril was found to be 2.29 min. The linearity was found satisfactory for the drug in the range 20.0-60.0 μg/mL (Table 1.4). Precision of the method was studied by repeated injection of tablet solution and results showed lower % RSD values (Table 1.5-1.7). This reveals that the method is quite precise. The percent recoveries of the drug solutions were studied at three different concentration levels. The percent individual recovery and the % RSD at each level were within the acceptable limit (Table 1.8). This indicates that the method is accurate. The absence of additional peaks in the chromatogram indicates non-interference of the commonly used excipients in the tablets and hence the method is specific. The deliberate changes in the method have not much affected the peak tailing, theoretical plates and the percent assay. This indicates that the present method is robust (Table 1.9). The system suitability studies were carried out to check various parameters such as theoretical plates and tailing factor (Table 1.10). The lowest values of LOD and LOQ as obtained by the proposed method indicate that the method is sensitive (Table 1.11). The solution stability studies indicate that the drug was stable up to 24 hours (Table 1.12). The forced degradation studies indicate that the drug was stable in stability studies (Table 1.13).
STRUCTURAL FLOOD DEFENCE MEASURES AND EFFECTS ON THE SURROUNDINGS
Authors: Peter Anthony , Adeola Mathew Fatuki,
Published: February 2023

Floods are one of the major natural disasters that threaten many human lives and causes significant economic losses globally every year. The aftermath of flood on society depends on the affected country’s economic strength prior to the disaster. The larger the disaster and the smaller the economy, the more significant is the effect. This is clearest seen in developing countries, where weak economies become even weaker afterwards. The research work emphasizes structural Engineering work as measures for flood defence, which include: Levees, Storm sewer system, Storm surge protection works, Spillways, Dyke, Renaturalization and Dams. The influences and drawbacks of these measures were discussed and the enormous advantages of Dam which is the major defence measures analyzed.
STUDY OF THE STRUCTURE OF PHOTONIC CRYSTAL FIBER WITH HIGH NEGATIVE DISPERSION COEFFICIENT
Authors: Xing-fang Jiang , Chen-yang Sun
Published: February 2023

The optical fiber communication has been second topics only to robot study for today. In the process of the Dense Wave-Length Division Multiplexing (DWDM) study, the problem of the dispersion compensate for the traditional optical fiber is a difficult problem to be solved for long distance transport information. In order to solve this problem, it is half work and times time by experimental study on photonic crystals with high negative dispersion structure. The advanced COMSOL Multiphysics many physical fields coupling calculation software is preferred. The research methods are that the structural parameters are adjusted for the traditional hexagonal photonic crystal fiber and the negative dispersion coefficient is obtained as far as possible large. Then the structure that the several layers with same spacing is designed and the structure is with ultra-high negative dispersion coefficient. The result shows that it is several ten times of the domestic level and it is 1.1 times of the international level. It is times work and half time by COMSOL Multiphysics many physical fields coupling calculation software in Modeling, mesh subdivision, calculation and analysis. The result is the theory basis for DWDM.
PKM PROMOSI DAN PENJUALAN KAIN TENUN DAN PRODUK UMKM DI DESA SUKARARA KECAMATAN JONGGAT
Authors: Masyhudi Lalu , Anggia Praba Putri  , Bagus Satra Putra  , Baiq Pindayu Widianiswara  , Dwi Cahya Andira  , I Gde Putu Wandita Yudistira  , Kurnia Sri Astuti  , Muh. Yusril Hamzani Saputra  , Ni Komang Ayu Triani Asih  , Rizal Pratama  , Silvia Maharani Safitri  , Sainul Abidin Ali  , Tekad Sukomardojo
Published: February 2023

Desa Sukarara merupakan Desa penyangga dari Kawasan Ekonomi Khsus Mandalika yang memiliki peluang besar untuk menyediakan produk dan jasa untuk mendukung kegiatan kepariwisataan di Lombok Tengah, karena lokasi Desa ini hanya memerlukan waktu sekitar 20 menit dari Bandara Internasional Zainudin Abdul Majid dan sekitar30 menit menuju ke Kawasan Ekonomi Kreatif Mandalika, sehingga desa ini merupakan desa yang sangat potensial untuk di kunjungi. Desa sukarare telah lama di tetapkan menjadi desa wisata tetapi belum maksimal, sehingga butuh promosi yang berkelanjutan agar kain tenun yang di hasilkan oleh masyarakat berdampak positif terhadap pendapatan masyarakat. Metode yang digunakan dalam pengabdian ini berupa perencanaan, pelaksanaan, dan evaluasi. Hasil kegiatan pengabdian adalah dengan adanya kegiatan pengabdian ini masyarakat terbantukan dalam segi promosi kain tenun yang telah di hasilkan. Saran kegaitan pengabdian ini adalah Desa Sukarara sebaiknya lebih menguatkan sinergi dengan pokdarwis dan stakeholder lainnya untuk mendiskusikan dan melaksanakan program-program kepariwisataan di Desa Sukarara. Selain itu, penggalian potensi Desa Sukarara masih harus terus dilakukan supaya ada atraksi lain yang dapat di angkat sehingga memungkinkan untuk Desa Sukarara meningkatkan manfaat pariwisata bagi perekonomian, serta sebagai branding yang dapat menaikkan volume kunjungan wisatawan lokal maupun mancanegara untuk dapat menaikkan juga volume penjualan produk oleh-oleh yaitu kain tenun.
association of diabetes and obesity with severity of dengue fever
Authors: Noureen Sidra , Abbas Adil , Alam Mehboob , Bibi Maria , Wajahat Muhammad , Dur-e-Shahwar Dur-e-Shahwar , Ahmad Ijaz , Ahmed Usama , Tanveer Afifa , Sajjad Sabrina , Khurshid Mehtab , Zeb Shah
Published: February 2023

The arboviral infection dengue represents a global public health risk as the frequency of cases climbs across period and is anticipated to do so in the future. The fundamental mechanisms behind the concept between obesity and dengue, however, are rarely discussed. A number of variables, including the existence of cytokines that increase inflammatory response and deregulation of endothelium barrier protein production, contribute to plasma permeability, a defining feature of severe dengue. The key diabetes-related variables that impact endothelium functioning include th-1 skewed responses and the production of junctional-related proteins. Additionally, obesity affects lipid metabolism and the immune system, which increases viral multiplication and inflammatory processes. The common factor among individuals with diabetes and obesity is chronic inflammation, which results in endothelial dysfunction. Explored along with the disease's relationships with diabetes and obesity are the potential causes of comorbidities in severe dengue.
Bookshelf
Authors: Rissman Nick
Published: February 2023

Bookshelf guest reviewer Nick Rissman reviews Thomas Adès Studies (Cambridge, UK: Cambridge University Press, 2022), a collection of twelve essay by theorists and musicologists edited by Edward Venn and Phillip Stoecker. Several of the analyses discuss the vocal music of Adès.
John Musto’s Viva Sweet Love: An Exploration of Love in All its Forms
Authors: Zavracky Gregory
Published: February 2023

Viva Sweet Love is a cycle of five songs by American composer John Musto, settings of poetry by E.E. Cummings and James Laughlin. It provides detailed information on the cycle, including biographic information on the composer and poets, along with details about Musto’s general music style, technical considerations for the singer and pianist, poem synopses, and song analyses.
Reinforcement Learning for Disassembly System Optimization Problems: A Survey
Authors: Guo Xiwang , Bi Zhiliang , Wang Jiacun , Qin ShuJin , Liu ShiXin , Qi Liang
Published: February 2023

Survey/review study
Reinforcement Learning for Disassembly System Optimization Problems: A Survey

Xiwang Guo 1,2,*, Zhiliang Bi 2, Jiacun Wang 1, Shujin Qin 3, Shixin Liu 4, and Liang Qi 5

1 Department of Computer Science and Software Engineering, Monmouth University, New Jersey 07710, USA
2 Department of Information Control, Liaoning Petrochemical University, Fushun 113005, China
3 Department of Economic Management, Shangqiu Normal University, Shangqiu 476000, China
4 Department of Information Science and Engineering, Northeast University, Shenyang 110819, China
5 Department of Computer Intelligence Science and Technology, Shandong University of Science and Technology, Qingdao 266590, China
* Correspondence: x.w.guo@163.com
 
 
Received: 16 October 2022
Accepted: 28 November 2022
Published: 27 March 2023
 

Abstract: The disassembly complexity of end-of-life products increases continuously. Traditional methods are facing difficulties in solving the decision-making and control problems of disassembly operations. On the other hand, the latest development in reinforcement learning makes it more feasible to solve such kind of complex problems. Inspired by behaviorism psychology, reinforcement learning is considered as one of the most promising directions to achieve universal artificial intelligence (AI). In this context, we first review the basic ideas, mathematical models, and various algorithms of reinforcement learning. Then, we introduce the research progress and application subjects in the field of disassembly and recycling, such as disassembly sequencing, disassembly line balancing, product transportation, disassembly layout, etc. In addition, the prospects, challenges and applications of reinforcement learning based disassembly and recycling are also comprehensively analyzed and discussed.
Alcances de la Antropología Forense en el Contexto del Derecho Internacional Artículo de Revisión
Authors: Valera-Hurtado Emanuel E.
Published: February 2023

El objetivo de este trabajo es analizar los alcances de la Antropología Forense en el contexto del Derecho Internacional, siendo que ésta es una especialidad médico-legal que se orienta a la aplicación de los conocimientos, métodos y técnicas de la Antropología Física, la Antropología Cultural y la Arqueología, con el objeto de aportar a la resolución de casos judiciales, mediante la identificación de restos humanos o de personas, que han perdido su identidad por alguna circunstancia, o cuando se requiere la verificación o se duda de ésta, mediante estrategias con un alto rigor científico. En este sentido, la participación del antropólogo forense como perito dentro de los sistemas que corresponden a la esfera del Derecho Internacional, en especial con respecto a la vulneración de derechos humanos, o de las infracciones del Derecho Internacional Humanitario, o para generar medios de prueba para responsabilizar a Estados e individuos con respecto a los crímenes de lesa humanidad, lo que exige mayor desarrollo de metodologías para el abordaje de los casos complejos, que requieren innovaciones sustanciales para responder al incremento de la diversidad de modus operandi de los criminales y a los requerimientos del sistema de justicia internacional, con su correspondencia nacional.
Changes in Neuraxial Anesthesia Protocols and Improved Efficiency of Same-Day Discharge Total Knee Arthroplasty in an Ambulatory Surgery Center: A Retrospective Cohort Study
Authors: Calkins Tyler E. , Wing Clayton C. , Diltz Zachary R. , Mihalko William M. , Toy Patrick C.
Published: February 2023

Introduction:

This study evaluated the effect of bupivacaine versus mepivacaine spinal anesthesia and preoperative adductor canal block (ACB) on recovery, length of stay, pain, and complications of same-day discharge total knee arthroplasty (TKA) at a free-standing ambulatory surgery center.

Methods:

We performed a retrospective review of patients who underwent TKA between March 2018 and September 2019. The patients were grouped based on the neuraxial anesthetic regimen: bupivacaine with ACB, bupivacaine without ACB, and mepivacaine without ACB. Preoperative ACBs were discontinued in December 2018, and use of mepivacaine spinal anesthesia was initiated in March 2019. Length of stay in the postanesthesia care unit (PACU), time to controlled void and ambulation, postoperative pain, morphine milligram equivalents (MME), and transient neurologic symptoms were compared.

Results:

Ninety consecutive patients who underwent TKA were identified. Fifty patients received bupivacaine with ACB, 20 received bupivacaine without ACB, and 20 received mepivacaine without ACB. Mepivacaine spinal anesthesia led to a 93-minute shorter PACU stay (P < 0.001), 115-minute quicker time to void (P < 0.001), 60-minute earlier ambulation (P = 0.024), and 109-minute shorter total facility time (P = 0.003) but increased total MME (P = 0.049) despite nonsignificant difference in pain at discharge (P = 0.908) compared with bupivacaine. Patients receiving bupivacaine with and without ACB had a nonsignificant difference in pain scores at discharge, time to ambulation, and time to discharge (P ≥ 0.1). No transient neurologic symptoms or overnight stays were observed.

Discussion:

Mepivacaine spinal anesthesia for TKA safely facilitated more rapid same-day discharge through decreased times to controlled void and ambulation but with a slight increase in MME requirements. Discontinuing preoperative ACBs did not negatively affect PACU outcomes.
Anticancer activity of Heat Shock Protein 70 (HSP70) Inhibitor, JG-98, against human cervical cancer HeLa and ovarian cancer SKOV-3 cells
Authors: Yurtcu Nazan , Karademir Dilay , Ergul Mustafa , Cetin Ali , Tinelli Andrea
Published: February 2023

Cervical and ovarian cancer are two aggressive neoplasms for women, still with high mortality and morbidity. Among the molecules and compounds that have anticancer activity, it was studied the JG-98, a heat shock protein 70 (HSP70) inhibitor. It demonstrated inhibitory effects on the growth of neoplastic cells, mediated by the induction of apoptosis, with anti-proliferation activity on neoplastic cells via the apoptotic pathway. The authors investigated the antiproliferative effects of JG-98 on human cervical cancer HeLa and ovarian cancer SKOV-3, examined by a standard XTT assay. Apoptotic effects and oxidative status were also evaluated by flow cytometry, ELISA, and total oxidant status assays in HeLa cells, respectively. The IC50 values of JG-98 in HeLa and SKOV-3 cells were recorded as 1.79 and 2.96 μM, respectively. Flow cytometry results showed that JG-98 treatment remarkably increased the proportion of apoptotic cells at IC50 concentration. The JG-98 treatment significantly increased the proteins Bax, cleaved caspase 3, cleaved PARP, and 8-oxo-dG levels, all indicators of cellular apoptosis. These findings show that JG-98 significantly decreased cell proliferation and increased apoptosis in HeLa cells, suggesting that JG-98 has a promising anti-tumor effect in cervical and ovarian cancers.
Some biochemical tips in the etiopathogenesis of Pectus Excavatum
Authors: Harma Birsen , Kiran Tugba , Inceoglu Feyza
Published: February 2023

Pectus excavatum (PE) is the most common deformity among anterior chest wall abnormalities. Although many theories on the pathogenesis of PE have been described, the uncertainty is still going on whether it is a result of developmental, biochemical, or biomechanical reasons or their combination. The aim of this study was to evaluate the biochemical parameters that may cause or be associated with the development of PE between children with PE and their healthy peers.
A total of 33 patients' medical records were retrospectively analyzed who followed up because of pectus excavatum between 2019 and 2021. A control group was formed from 32 healthy children from the hospital records with similar age and gender profiles as the patient group. The data from both groups were collected and statistically analyzed in terms of gender, age, and laboratory tests, including hemogram, Vit B12, Parathormone (PTH), Vit.D, Alkaline phosphatase (ALP), and serum Calcium (Ca) and Phosphor (P) levels. Compared to the control group, statistically, significantly higher serum ALP, P, and PTH levels with low Vit.B12 levels were detected. The significant difference in the levels of ALP, PTH, P, and Vit B12, which have an important place in the construction and development of osteochondral structures, may impair the remodeling capacity of the costosternal structure with the contribution of thoracic biomechanics. When PE deformity is noticed, if appropriate medical treatment such as vitamin and mineral supplements and diet regulation is applied to children in the follow-up process, the process can be slowed down, and the deformity can be alleviated.
Pandemic process status questionnaire: Development and psychometric properties
Authors: CANDIRI Busra , TALU Burcu
Published: February 2023

The pandemic process has caused significant changes in many areas of daily life. The aim is to develop a new questionnaire to evaluate the changes that occurred during the pandemic process and to examine the psychometric properties of this questionnaire. For face validity, 10 individuals were asked to interpret the questions. The Pandemic Process Status Questionnaire was tested with the help of a questionnaire created with the help of Google Forms. In order to evaluate the content validity, the content validity index and content validity ratio were used in line with the opinions of 7 experts. A pilot test was carried out. Exploratory factor analysis was performed for construct validity. The World Health Organization Quality of Life-brief version was used for convergence validity. A total of 25 items with an impact score of less than 1.5 in face validity were deleted. According to the content validity index, 15 items and 21 items according to the content validity rate were removed. In the pilot application, 5 items with an item-total correlation below 0.3 were deleted. The results of the exploratory factor analysis provided 6 dimensions: general status, physical status, psychological status, social and economic status, concerns about the pandemic, and eating habits. This structure explained 71.77% of the total variance. The questionnaire showed a weak correlation with the World Health Organization quality of life-Short Form (r=0.26). The Pandemic Process Status Questionnaire is a short and valid tool to summarize the situation encountered during the pandemic process.
ASYNCHRONY IN FLUCTUATIONS OF THE MAXIMUM WATER LEVELS OF THE RIVERS IN THE BELARUSIAN POLESIE AND THE BELARUSIAN LAKELAND
Authors:   Brest State Technical University, Volchak A.A. , Shpoka D. A. ,   Brest State Technical University
Published: February 2023

A comparative analysis of the maximum water levels formation of the rivers in the Belarus-ian Lakeland and the Belarusian Polesie for the period from 1946 to 2015 was carried out. Three periods were studied: 1946…1965 – the period before the mass reclamation, the peri-od of minimal anthropogenic impacts, can be conditionally accepted as a natural water re-gime; 1966…1987 – the period of mass reclamation; 1988…2015 – the period of modern climatic impacts. The methodological basis of the research was the scientific provisions on the stochastic nature of the variability of the river level regime and the comparative geo-graphical method. It is established that for the rivers of the Belarusian Lakeland there is a steady tendency to decrease the maximum water levels at a rate of minus 31 cm / 10 years in general for the entire period under review, while there is a slight decrease for the rivers of the Belarusian Polesie.