bluuebunny/crossref_metadata_2025 huggingface dataset:
On a second-order integro-differential equation with difference kernels and power nonlinearity
Authors:   Chechen State Pedagogical University, Kadyrov Chechen State University, Askhabov S.N.
Published: July 2022

The article studies a second-order integro-differential equation with difference kernels and power nonlinearity. A connection is established between this equation and an integral equation of the convolution type, which arises when describing the processes of liquid infiltration from a cylindrical reservoir into an isotropic homogeneous porous medium, the propagation of shock waves in pipes filled with gas and others. Since non-negative continuous solutions of this integral equation are of particular interest from an applied point of view, solutions of the corresponding integro-differential equation are sought in the cone of the space of continuously differentiable functions. Two-sided a priori estimates are obtained for any solution of the indicated integral equation, based on which the global theorem of existence and uniqueness of the solution is proved by the method of weighted metrics. It is shown that any solution of this integro-differential equation is simultaneously a solution of the integral equation and vice versa, under the additional condition on the kernel that any solution of this integral equation is a solution of this integro-differential equation. Using these results, a global theorem on the existence, uniqueness and method of finding a solution to an integrodifferential equation is proved. It is shown that this solution can be found by the method of successive approximations of the Picard type and an estimate for the rate of their convergence is established. Examples are given to illustrate the obtained results.
PVP/PVA blended hydrogels as a biofilm for use in food packaging applications
Authors: Gökmen Fatma Özge
Published: July 2022

Bio-films have been produced that attract attention with their functional behavior among conventional food packaging materials of bio-based polymer blends. The physical and morphological properties of copolymeric biofilms have been extensively investigated. Biodegradable polymer and copolymer films were produced by in situ polymerization technique and prepared as solution casting. The strong water absorbency of polyvinyl alcohol and the antimicrobial property of polyvinylpyrrolidone are combined in a single material. Structural and morphological properties of the films were characterized by Fourier-Transform Infrared Spectroscopy and Scanning Electron Microscope analysis. These results show that the films obtained can be used as an environmentally friendly bio-based polymer blend packaging material to extend the shelf life of food products.
Effects of micronized sugar beet dietary fiber addition on the properties of wheat dough and bread
Authors: Hançer Ayla , Karabulut İhsan , Gökbulut İncilay
Published: July 2022

The aim of this study is to determine the effect of sugar beet fiber, micronized by high pressure homogenization, addition on the rheological and textural properties of wheat dough and the quality parameters of bread. The micronized and unmicronized sugar beet fibers were used in the bread formulation and they were incorporated into flour at levels of 2, 4, 6, 8, and 10%. The addition of sugar beet fiber increased the storage modulus (G′) and loss modulus (G″) values and led to more solid-like and elastic bread dough. Also, the hardness values of bread dough increased while the gumminess and adhesiveness values didn’t change significantly. The addition of sugar beet fiber significantly decreased the volume of bread samples (P ˂0.05). The effect of fiber addition on the textural properties of bread was determined and it was observed that the hardness and chewiness of bread samples increased while the cohesiveness and springiness parameters didn’t change. Sugar beet fiber addition significantly decreased the lightness (L) values and increased the redness (a) values of the crumbs. According to the results of sensory analysis, all bread samples that contain sugar beet fiber were evaluated as acceptable by the panelists. The bread samples that contain unmicronized sugar beet fiber at a 4% level and micronized sugar beet fiber at a 2% level got similar scores to the control bread. Micronization by high pressure homogenization has developed functional properties of sugar beet fiber and it is understood that it could be used in various foods.
Derin Öğrenme ile Alzheimer Hastalığı Teşhisi İçin Model Önerisi
Authors: ÖZKAYA Anıl , CEBECİ Ufuk
Published: July 2022

Alzheimer's disease is one of the greatest health problems of our time. Since there is no cure, it is necessary to diagnose the disease in the early stages and to apply preventive treatments. However, early diagnosis of the disease is very difficult, so most people can be diagnosed after significant and irreversible effects occur. Various studies are carried out by researchers around the world for the early diagnosis of the disease. Deep learning has recently gained importance in the early diagnosis of Alzheimer's disease. With the use of models created using deep learning, the success of early diagnosis has reached high levels. In this study, the stages of Alzheimer's disease and the changes that occur were examined. A literature review was conducted for various techniques used in the diagnosis of Alzheimer's and the use of imaging techniques in the early diagnosis of Alzheimer's was investigated. Due to its widespread use, the MRI technique has been emphasized, and mostly studies using MRI have been examined. Concepts used in deep learning are explained, innovations and results are presented. The architectures used in deep learning and the innovations they bring to this field are revealed, and deep learning models that have been created and tested in current studies are examined. The innovations and success rates brought by various studies have been revealed. Efforts have been made to develop a fast, efficient and successful model that provides ease of use. For this, the scheduler structure, MONAI framework, Data loader structure and various techniques are presented with simple use. Also, the model is optimized to run smoothly on Google Colab. In addition, the tools in the FSL library, which are very important in preprocessing, were studied and optimal parameters were found for the "Bias field and Neck Clean Up", "Standard Brain Extraction Using BET2" and "Robust Brain Center Estimation" tools. By using this library, optimal brain images can be obtained for any model. The DenseNet121 model was used as a basis in the model and it was presented in a structure that can be easily changed. The model can directly use 3D MR images, thus preventing the loss of various spatial information.
Cross-border mergers and acquisitions
Authors: BYTSIURA Yurii
Published: July 2022

Introduction. Cross-border mergers and acquisi­tionshelp increase global competitiveness. Problem. Taking into account the trend of strengthening integration processes in the interna­tional economy, it is especially important to study the foreign experience of cross-border mergers and acquisitions, analyze their effectiveness and find ways to improve this market. An analysis of recent research and publications has shown that despite the existence of some scientific achievements, an important scientific and practical problem of the characteristics of cross-border mergers and acquisitions in accordance with current trends in the international economy remains unresolved. The aim of the article is to identify the chara­cteristics, analysis of the current state and trends of cross-border mergers and acquisitions. Materials and methods. In the course of the research the materials of the State Statistics Service of Ukraine, reports of international organizations and scientific works of scientists on cross-border mergers and acquisitions were used. Methods of abstraction, analysis and synthesis, generalization, historical method, structural-functional method, etc. were used. Research results. Characteristic features and tendencies of cross-border mergers and acquisitions are determined: periodic alternation of world economic crises and stock market falls (2008–2009, 2011, 2020); mainly occur in industries with a high level of monopolization (technological and financial sectors, energy); agreements are increasingly being concluded at the initiative of private investment funds or large corporations from the BRICS countries. It is established that the leaders of cross-border mergers and acquisitions, which serve as an important source of attracting foreign investment, are companies in North America and Europe. Conclusions. The main ways to improve the market for cross-border mergers and acquisitions are: increasing the capitalization of national companies and their investment attractiveness; increasing the volume and quality of products; development and implementation of new technologies; modernization of the sectoral structure of the economy; development of transport and financial infrastructure; develop­ment of the domestic stock market, ensuring openness and reliability of financial statements; improving the regulatory framework; stabilization of the military-political situation.
Finance of the International Monetary Fund
Authors: CHUGUNOV Igor , KUCHER Galyna
Published: July 2022

Introduction. The institutional transformationof the IMF is aimed at ensuring global financial stability. This requires a study of changes in approaches and mechanisms for the formation and use of financial assets and indicators that determine the effectiveness and efficiency of its activities. Problem. The institutional development of the IMF requires adequate resources and improvement of the internal system of financial relations, mechanisms of accumulation and redistribution of financial and credit flows.Understanding the features and consequences of such transformations is important for the development of both the global financial system as a whole and individual sovereign countries, the stability of which has long depended on cooperation with the IMF. The aim of the article is aimed at identifying the content and impact of improving the functioning of the IMF’s finances to ensure the stability of the global financial system. Methods. To reveal the peculiarities of the formation and use of financial resources, the systematic method is used, while scientific abstraction and generalization are used to deter­mine the financial architecture, and methods of analysis and synthesis are used to analyse the IMF financial performance. Results. The development of the global financial environment effects the IMF financial architecture and performance. Indicators of accu­mulation and use of own and borrowed funds are studied.The IMF financial performance for 2019–2020 is estimated. The role of the IMF in ensuring the stability of the world’s financial system is revealed. Conclusion. The institutional development of the IMF is aimed at ensuring the stability of the global financial system and meeting the needs of the world community for resources. Improving the IMF’s financial management reflects thestrengthening of its financial and credit capacity by increasing the member countries’quotas, using gold reserves and borrowing, optimizing costs, and ensuring the efficiencyfunctioning.
Exchange rates and purchasing power parity: the case of Central European
Authors: STANIŠIĆ Nenad , JANKOVIĆ Nenad
Published: July 2022

Introduction. The question of how exchange rates adjust is central to exchange rate policy, since countries with fixed exchange rates need to know what the equilibrium exchange rate is likely to be and countries with variable exchange rates would like to know what level and variation in real and nominal exchange rates they should expect. In broader terms, the question of whether exchange rates adjust toward a level established by purchasing power parity helps to determine the extent to which the international macroeconomic system is self-equilibrating Analysis of recent researches and publications has shown that the published up to date papers aren’t systematic and can’t claim to be a complete analysis in the chosen field. The aim is to test the validity of PPP hypothesis in the long run in former and current European transitional economies. Methods. General scientific methods such as the systematic approach, theo­retical generalization and comparison, analysis, synthesis and the Levin–Lin–Chu (LLC) panel unit root test have been used in the research. Research results. This paper tests the validity of purchasing power parity (PPP) hypothesis in the long run in selected European transitional economies. The database used in this paper contains monthly data on real effective exchange rate (REER) observed over 23 years, from March 1995 till November 2017. To test the hypothesis, the Levin–Lin–Chu (LLC) panel unit root test was employed. The results confirm that PPP holds both for Central European and Western Balkan states in the long run. Conclusions. The equilibrium exchange rate question is central question to exchange rate policy. Purchasing power parity hypothesis was tested on the sample of 14 European countries form the Central and Eastern Europe and Western Balkan region. The database used in this paper contains monthly data on real effective exchange rate –REER observed over 23 years, from March 1995 till November 2017. As PPP holds if the real exchange rate reverts to its equilibrium value over time, the unit root test was applied on panel REER dataset. The results of applied Levin–Lin–Chu (LLC) panel unit root tests confirmed that the PPP hypothesis holds for selected countries during the observed period. Additionaly, results confirmed that PPP hypothesis holds both for CEE and Western Balkan countries separately.
The latest imperatives for the transformation of the EU budget system
Authors: BOIAR Andrii
Published: July 2022

Introduction. In the context of the COVID-19 pandemic, military-political, migration, terrorist, environmental and other security threats, European integration ambitions of Ukraine and other Eastern European countries, there is a markedly growing cognitive interest in various aspects of the EU’s functioning, including its financial and budgetary provisions. Analysis of recent research and publications. There are many attempts by European scientists to interpret and justify the structure of the revenues and expenditures of the EU budget. Materials and methods. The study is based on a systematic approach and is carried out using methods of empirical, historical-comparative, structural analysis, financial and statistical, graphic and some other general scientific methods. Results. In addition to structural composition of two parts inherent in any budget – revenue and expenditure – the EU budget system is cha-racterized by the presence of a number of additional elements and mechanisms due to the supranational features of its formation and dynamic target guidelines for the development of the integration association itself. In recent years, it has undergone significant transfor-mations. In order to promote accelerated post-pandemic recovery, an unpre¬cedented financial instrument «New Generation EU» has been created in the EU. Such new financial instruments as the Recovery and Resilience Facility, InvestEU and RescEU programs. Conclusions. The EU’s system of political priorities has been significantly transformed in recent years under the influence of the latest challenges and threats. From the fiscal point of view it improves the chances for Ukraine to implement its European integration aspirations after 2027.
Indicators for assessing the efficiency of enterprises of the public sector of the economy
Authors: PARASII-VERHUNENKO Iryna
Published: July 2022

Introduction. There are various organiza­tional and legal forms of state-owned enter­prises in Ukraine which, on the one hand, can be considered an advantage because govern­ment agencies have freedom of choice in terms of their participation in them, and on the other hand, many state-owned enterprises comp­licate control procedures, effective use of state property. Problem. The recent trend in the efficiency reduction of public sector enterprises in Uk­raine requires development of productive mecha­nisms for managing state property, which rai­ses the issue of improving its analytical support. The aim of the article is to develop a system of analytical indicators for the purpose of monitoring the efficiency of public sector enterprises, taking into account the purpose of their formation and strategic goals. Methods. Such methods as analysis, syn­thesis, induction, deduction, comparison, obser­vation, grouping, systematization, relative values, genera­lizations were used in the paper. Results. The comparative analysis of the normative legal acts regulating the order of the efficiency estimation of the state enter­prises performance and their shortcomings have been carried out. The indicators system for the control purposes for the efficiency of the public sector enterprises performance in the context of the following analytical blocks such as budget effi­ciency, economic efficiency and financial stabi­lity, status, dynamics and structure of assets, social efficiency has been improved. Conclusions. Improving methodological app­roaches to the formation of the effective mana­gement criteria for state enterprises should be based on a differentiated approach to the list of indicators and their estimated values depending on the types, functions and object­tives of public sector enterprises.
Financing of municipal enterprises: European experience
Authors: BAGATSKA Kateryna
Published: July 2022

Introduction. The article studies the practice and methods of the municipal owned enterprises management in the EU, including methods of forming their capital. Problem. Ukrainian decentralization reform has increased the scientific interest in the problematic issues of municipal owned enterprises’ financing. Military aggression against Ukraine have raised these issues. The aim of the article is disclosure, systematization and generalization of European experience in the organization, management and financing of municipal in European countries and development of proposals for the use of best practices in Ukraine. Methods. Methods used: historical, genera­lization; analysis using tabular and graphical; inductive; abstract-logical. Results. The practice of the municipal owned enterprises capital formation is characterized by the two types of relations: full ownership of the municipality or mixed ownership. The number of the municipal owned enterprises in the EU has increased in recent years, but this growth has been uneven. Provision of financial support to such enterprises by local authorities is carried out in the following forms: grants, tax conditions, loans and direct financial support. Conclusions. There is no unified practice for the financing of municipal enterprises in the EU, as there is no significant diversity in terms of countries. There is also no significant trend towards total privatization, in many European countries the number of utilities is growing, which indicates the increasing of the public sector influence on the economic situation in the EU. The solution to the problems of our municipal companies must lie in the adoption of the best European practices. In particular, the provision of grants to finance socially significant enterprises or enterprises in financial difficulties can be considered as one of the best practice.
Transformation of Ukraine’s trade relations in the Middle East and Africa
Authors: OMRAN Hossein
Published: July 2022

Introduction. On February 24, 2022, the terri­tory of Ukraine was attacked by the Russian Federation, and for the fourth month the country’s economy has been under the destructive influence of this aggression. Problem. At the stage of post-war reconst­ruction, which begins in various regions of Ukraine as soon as active hostilities cease, it will be important to restore the stable functioning of Ukrainian industries and return to international markets of major domestic exporters. Increasing the effectiveness of foreign trade is one of the main sources of financial resources to fill the budgets of different levels. The aim of the article is to identify the changes in Ukraine’s trade cooperation with the states of the Middle East and Africa in the post-war reconstruction. Methods. A set of complementary methods of scientific identification of economic processes and phenomena is applied: system-structural, comparative and statistical analysis, as well as process, infor­mation and institutional approaches. Results. The conditions and factors of development of each of the countries of the Middle East and North Africa lead to the formation of its own trajectory of trade ties with Ukraine. In order to determine the prospects and strategic priorities in the formation of relations with these countries, a comparative analysis of trade coo­peration with each of them. The calculated indicators demonstrate the importance of the region's markets as strategic, their loss may have a negative impact on Ukraine’s balance of payments, especially in martial law and further post-war reconstruction. Conclusions. Solutions that can ensure the rapid recovery of Ukraine should combine existing support instruments, as well as the process of forming a comprehensive long-term approach to the planning and implementation of national economic interests.
Antero-lateral transthoracic endoscopic approach for a calcified thoracic disc herniation
Authors: Fernández Roque Carlos , Mesa Miguel , Rosenthal Daniel , Rodrigo Paradells Victor
Published: July 2022

Thoracic disc herniation is one of the most therapeutically challenging spine conditions. A myriad of surgical approaches have been described in the literature, including posterior, anterior, and combined techniques. However, transthoracic and retropleural approaches are currently deemed the most effective techniques to successfully obtain anterior decompression. Herein the authors describe a 65-year-old female patient who underwent a transthoracic endoscopic approach to remove a calcified herniated thoracic disc that caused spinal cord compression. Despite having a long learning curve, the surgical technique described herein can be even used in patients with complex and calcified thoracic disc herniations.

The video can be found here: https://stream.cadmore.media/r10.3171/2022.3.FOCVID221
Arteriovenous malformations of the filum terminale: clinical characteristics, angioarchitecture, and management of a rare spinal vascular pathology
Authors: Mull Michael , Dafotakis Manuel , Schubert Gerrit Alexander , Hans Franz-Josef , Jablawi Fidaa
Published: July 2022

OBJECTIVE

The goal of this study was to describe clinical and neuroradiological features of arteriovenous malformations of the filum terminale (FT AVMs) and to present the authors’ diagnostic and therapeutic management in this rare disease.

METHODS

The presented cases were retrieved from a retrospectively collected database of all spinal vascular malformations treated between June 1992 and December 2021 at the Rheinisch-Westfälische Technische Hochschule (RWTH) University Hospital Aachen. Pretreatment and follow-up clinical and neuroradiological data were analyzed for this study.

RESULTS

Data in 15 patients with FT AVM with a mean age of 60 years were included, with an overall incidence of FT AVM of 19% among all spinal AVMs in our cohort. Twelve of 15 (80%) patients were men. Nonspecific but typical clinical and MR findings of thoracolumbar congestive myelopathy were found in all patients. Spinal MR angiography, performed in 10 patients, identified in all cases the arterialized FT vein as well as a lumbar/lumbosacral location of an AV shunt. Digital subtraction angiography (DSA) showed an arterial supply solely via the FT artery in 12/15 (80%) patients and via an additional feeder from the lumbosacral region in the other 3/15 (20%) patients. All patients were treated surgically. During 1-year follow-up, 2 patients presented with recurrent FT AVM due to further arterial supply from the lumbosacral region, and were treated surgically. Neurological status was improved in all patients within the 1-year follow-up, with marginal further changes during long-term follow-up.

CONCLUSIONS

Congestive myelopathy is the major pathological mechanism of symptoms in these patients, with no evidence for intradural bleeding. Missing the presence of possible multiple arterial supply of FT AVM during DSA may result in misdiagnosis and/or insufficient treatment. Due to the frequently prolonged course of FT artery, resection of the FT AVM may be a favorable treatment modality in comparison with endovascular treatment. Follow-up examinations are obligatory within the first 3 years after treatment, and further MR angiography and DSA examinations are indicated if congestive myelopathy persists.
Emerging pathogenic mechanisms in human brain arteriovenous malformations: a contemporary review in the multiomics era
Authors: Winkler Ethan A. , Pacult Mark A. , Catapano Joshua S. , Scherschinski Lea , Srinivasan Visish M. , Graffeo Christopher S. , Oh S. Paul , Lawton Michael T.
Published: July 2022

A variety of pathogenic mechanisms have been described in the formation, maturation, and rupture of brain arteriovenous malformations (bAVMs). While the understanding of bAVMs has largely been formulated based on animal models of rare hereditary diseases in which AVMs form, a new era of “omics” has permitted large-scale examinations of contributory genetic variations in human sporadic bAVMs. New findings regarding the pathogenesis of bAVMs implicate changes to endothelial and mural cells that result in increased angiogenesis, proinflammatory recruitment, and breakdown of vascular barrier properties that may result in hemorrhage; a greater diversity of cell populations that compose the bAVM microenvironment may also be implicated and complicate traditional models. Genomic sequencing of human bAVMs has uncovered inherited, de novo, and somatic activating mutations, such as KRAS, which contribute to the pathogenesis of bAVMs. New droplet-based, single-cell sequencing technologies have generated atlases of cell-specific molecular derangements. Herein, the authors review emerging genomic and transcriptomic findings underlying pathologic cell transformations in bAVMs derived from human tissues. The application of multiple sequencing modalities to bAVM tissues is a natural next step for researchers, although the potential therapeutic benefits or clinical applications remain unknown.
Antibiotics Use in Hospitalised COVID-19 Patients in a Tertiary Care Centre: A Descriptive Cross-sectional Study
Authors: Thapa Bibechan , Pathak Samyam Bickram , Jha Nisha , Sijapati Milesh Jung , Shankar Pathiyil Ravi
Published: July 2022

Introduction: Antimicrobial resistance is a global health problem. The widespread and improper antibiotics use is the leading cause of antimicrobial resistance. Bacterial co-infection in COVID-19 patients is the basis for the use of antibiotics in the management of COVID-19. COVID-19 pandemic has seriously impacted antibiotic stewardship and increased the global usage of antibiotics, worsening the antimicrobial resistance problem. The use of antibiotics among COVID-19 patients is high but there are limited studies in the context of Nepal. This study aimed to find out the prevalence of antibiotic use among hospitalised COVID-19 patients in a tertiary care centre.
Methods: A descriptive cross-sectional study was conducted on hospitalised COVID-19 patients from April 2021 to June 2021 in a tertiary care centre. Ethical approval was taken from the Institutional Review Committee (Reference number: 2078/79/05). The hospital data were collected in the proforma by reviewing the patient’s medical records during the study period of 2 months. Convenience sampling was used. Point estimate and 95% Confidence Interval were calculated.
Results: Among 106 hospitalised COVID-19 patients, the prevalence of antibiotic use was 104 (98.11%) (95.52-100, 95% Confidence Interval). About 74 (71.15%) of patients received multiple antibiotics. The most common classes of antibiotics used were cephalosporins, seen in 85 (81.73%) and macrolides, seen in 57 (54.81%) patients.
Conclusions: The prevalence of antibiotic use among hospitalised COVID-19 patients was found to be higher when compared to other studies conducted in similar settings.
Modern Paediatric Radiology: Meeting the Challenges in CT and MRI
Authors: Regmi Pradeep Raj , Amatya Isha , Paudel Sharma , Kayastha Prakash
Published: July 2022

Radiology plays a very important part in the diagnosis, treatment, and follow-up of children. Computed tomography and magnetic resonance imaging are the two most crucial developments in the modern era. However, the two modalities have their challenges to overcome. Radiation dose is the most unwanted side effect of computed tomography scans while longer scan time along with sedation is a major disadvantage in children during magnetic resonance imaging. Paediatric-specific protocol selection and limiting the exposure to the area of interest aid in reducing the dose during computed tomography scans. Faster scan protocols and sequences can result in imaging without sedation in magnetic resonance imaging. Considering the radiation exposure, "as low as reasonably achievable" principle should be followed strictly in the paediatric population. In this article, possible ways for minimising the radiation dose in computed tomography, as well as effective, short, and sedation-free magnetic resonance imaging, are discussed.
Primary Meningeal Melanomatosis: A Case Report
Authors: Lowenthal J.M. , Girgis P. , Labib M.L.
Published: July 2022

Primary meningeal melanomatosis is a rare tumor of the central nervous system accounting for only up to 0.1% of all CNS tumors and 1% of all melanocytic tumors. We present a case of primary meningeal melanomatosis involving the entire neuroaxis and review the relevant imaging findings
and literature.
PENGUATAN PENGGUNAAN TEKNOLOGI UNTUK LAYANAN ADMINISTRASI KEPENDUDUKAN DI LINGKUNGAN RW 09 KELURAHAN SIDOMULYO TIMUR KECAMATAN MARPOYAN DAMAI KOTA PEKANBARU
Authors: Dwi Haryono, M.Kom  , Wirta Agustin  , Rini Yanti  , T.Sy. Eiva Fatdha  , Helda Yenni
Published: July 2022

Kegiatan pengabdian kepada masyarakat yang telah dilaksanakan bertujuan untuk peningkatan pemahaman masyarakat RW 09 Kelurahan Sidomulyo Timur Kecamatan Marpoyan Damai Kota Pekanbaru terhadap pemberdayaan teknologi dalam mengakses layanan administrasi kependudukan secara online. Layanan administrasi kependudukan merupakan salah satu program pemerintah Kota Pekanbaru untuk mewujudkan visi Smart City yang madani. Pengukuran pemahaman peserta dilaksanakan dengan mengadakan pre-test dan post-test. Metode yang digunakan dalam pengabdian ini adalah PIECES ( Performance, Information/Data, Economic, Control/Security, Efficiency, dan Service) Hasil akhir kegiatan menunjukkan bahwa menambah wawasan dan pengetahuan  dalam  proses  layanan  Kependudukan secara online kepada warga RW 09 Kelurahan Sidomulyo Timur Kecamatan Marpoyan Damai Kota Pekanbaru
PELATIHAN MEMBUAT WEBSITE DAN JARINGAN LAN KOMPUTER BAGI SISWA SMA NEGERI 4 TUALANG KAB. SIAK
Authors: Toresa Dafwen , Taslim  , Susi Handayani  , Musfawati
Published: July 2022

Sekolah Menengah Atas (SMA) Negeri 4 Tualang yang beralamat di Desa Maredan Kecamatan Tualang Kabupaten Siak adalah sekolah negeri yang lokasinya cukup jauh dari keramaian dan berlokasi di tengah perkebungan sawit. Sekolah ini tergolong  baru dan beroperasi 4 tahun ini. Memiliki 4 gedung yang terdiri dari 1 gedung kantor dan 3 gedung untuk proses belajar mengajar (PBM). Sekolah ini juga memiliki keterbatasan guru, terutama untuk guru bidang Teknik Informatika Komputer (TIK) yaitu hanya 1 (satu) orang, pelajaran TIK yang diajarkan hanya Aplikasi MS Office dan Selama ini siswa belajar komputer dengan materi TIK yang terbatas dikarenakan tenaga pengajar dan penguasaan materi yang belum menguasai banyak tentang TIK sebagaimana seharusnya. Oleh karena itu maka diperlukan pelatihan dasar membuat website dan dasar jaringan LAN komputer bagi siswa. Pelatihan dilaksanakan 2 (dua) hari dengan materi berbeda dan dilaksanakan secara kombinasi teori dan praktek langsung sampai berhasil. Hari pertama siswa mempelajari dari dasar tentang konsep webserver, membuat webserver, konsep website secara teori dan praktek membuat website sampai pada akhirnya peserta bisa membuat website sendiri. Pada hari kedua peserta mempelajari tentang Jaringan komputer local, dimulai dari teori jaringan, tools jaringan, alamat komputer, pengenalan kabel jaringan, switch dan langkah membuat jaringan komputer local, pada akhirnya peserta bisa membuat jaringan lokal komputer dan menghubungkan semua komputer yang digunakan saat pembuatan webserver dan website. Metoda ini memberikan pemahaman dan kompetensi pada peserta dalam memahami konsep kerja internet secara simulasi, yaitu mengakses sebuah alamat website dari komputer yang berbeda.
Computer Synthesis of Neurotransmitter Images
Authors: Makarov L. , Pozdnyakov A.
Published: July 2022

He semantic sign system is considered, represented by two different sets of elements, through which creative objects are created, correlated with the natural activity of man and Nature, reproducing numerous species of living organisms. Using the concepts and definitions of work processes in neural networks, the principles of creating neural transmitter images are considered. Formalizing the processes of creation of creative objects, a topological computational model of computer synthesis of neurotransmitter images with a variety of forms is presented.
Correlations Between High-mobility Group Box 1 and Th1/Th2 Cytokines in Peripheral Blood of Patients with Unexplained Recurrent Spontaneous Abortion
Authors: Fu Dan
Published: July 2022

The researchers aimed to explore the correlations between high-mobility group box 1 (HMGB1) and T helper cell (Th1/Th2) cytokines in the peripheral blood of patients with unexplained recurrent spontaneous abortion (URSA). After treatment, IL-2, IFN-ã and HMGB1 expressions significantly declined, while IL-4 and IL-10 expressions rose in URSA group (P<0.05). HMGB1, IL-2 and IFN-ã expressions were significantly lower and IL-4 and IL-10 expressions were higher in the successful pregnancy group than those in the failed pregnancy group (P<0.05). HMGB1 was positively correlated with IL-2 and IFN-ã, while negatively correlated with IL-4 and IL-10 (P<0.01). Th1 cell percentage and Th1/Th2 ratio were significantly higher and Th2 cell percentage was lower at 12 and 24 hours, than those under stimulation with HMGB1 at 0 hours (P<0.05). URSA is associated with the shift of Th1/Th2 balance toward Th1. HMGB1 may regulate the balance of Th1/Th2 immune response, as a potential target for treating URSA.
Associations of OPRM1 A118G Gene Polymorphism with Pain Sensitivity and Opioid Dosage of Patients with Postherpetic Neuralgia
Authors: Fu Qiang
Published: July 2022

This study aimed to explore the associations of OPRM1 A118G gene polymorphism with pain sensitivity and opioid dosage of patients with postherpetic neuralgia (PHN). According to the 3-month follow-up results, 103 PNH patients were enrolled as a PHN group, and 112 without PHN after herpes zoster were included as a non-PHN group. The factors affecting PHN occurrence were subjected to one-way analysis of variance and multivariate logistic regression analysis. The frequency distribution of GG, AG and AA genotypes in both PHN and non-PHN groups conformed to the Hardy-Weinberg equilibrium law (P>0.05). Initial treatment duration of more than 72 hours, severe acute pain and genotype GG were independent risk factors for PHN. Genotype GG exhibited significantly increased distribution frequency in mild, moderate and severe PHN groups. The 48-hour opioid dosage was highest in the patients with genotype GG (P<0.05). OPRM1 A118G gene polymorphism causes individual differences in the pharmacodynamics of opioids in PHN patients.
Long Noncoding RNA FENDRR Facilitates Progressions of Hemangioma Endothelial Cells via Sponging MicroRNA-424
Authors: Liu Qiang
Published: July 2022

The present study investigated effects of FENDRR and miR-424 on modulating HemECs progressions. Using RT-qPCR, FENDRR was detected to be upregulated in HemECs. The knockdown of FENDRR inhibited HemECs viability, migratory and invasive abilities but accelerated the cell apoptosis. Additionally, MMP-9 and VEGFA were also suppressed. Luciferase reporter test then verified that miR-424 in HemECs was sponged by FENDRR and downregulated in HemECs. Furthermore, overexpressed FENDRR restrained miR-424 mimics-induced high miR-424 expression. Beyond that, suppressed HemECs viability, invasiveness and migratory ability and increased apoptosis caused by miR424 mimics were also reversed by FENDRR overexpression. Moreover, miR-424-induced low MMP-9 and VEGFA were restored by overexpressed FENDRR.
Visual Identity Elements Used by Pharmacies in Romania
Authors: Neacsu Nicoleta Andreea
Published: July 2022

In a highly competitive market, such as that of pharmacies in Romania, the elements of visual identity help to seduce consumers, to recognize the brand of a pharmacy, making it easier to recognize and more familiar to a consumer. The paper aims to identify the main elements of visual identity used in the Romanian pharmaceutical market and to determine the opinions, attitudes, and perceptions of consumers regarding these elements. For this purpose, an exploratory analysis was performed combined with quantitative market research.
The New Iterative Approximating of Endpoints of Multivalued Nonexpansive Mappings in Banach Spaces
Authors: KAPLAN Makbule
Published: July 2022

The purpose of this paper is to introduce the new iteration process to approximate endpoints of multivalued nonexpansive mappings in Banach space. We prove weak and strong convergence theorems of proposed iterative scheme under some suitable assumptions in the framework of a uniformly convex Banach space.
MRI background parenchymal enhancement in patients with invasive lobular carcinoma: Endocrine hormonal treatment effect
Authors: Grubstein Ahuva , Rapson Yael , Manor Moran , Yerushalmi Rinat , Gavrieli Shlomo , Tamir Shlomit , Meshulam Sagit , Atar Eli , Stemmer Salomon M. , Shochat Tzippy , Allweis Tanir M.
Published: July 2022

OBJECTIVES: High background parenchymal enhancement (BPE) levels and asymmetric distribution could cause diagnostic uncertainty due to morphological similarity to breast cancer, especially invasive lobular carcinoma (ILC). We investigated BPE in ILC patients, its association with the tumor hormonal profile, and the effect of endocrine treatment (ET). METHODS: The analysis included all MRI examinations performed at our institution between 2010 and 2019 for ILC-diagnosed patients. Baseline study and the first follow-up study were reviewed. Digital medical records were reviewed to retrieve demographics/pathology results/treatment information. BPE and fibroglandular tissue were assessed qualitatively on the contralateral breast according to the criteria of the Breast Imaging Reporting and Data System (BI-RADS). RESULTS: The study included 129 patients. Most (91%) had pure ILC. All received ET; 12% also received chemotherapy; 90% had surgery first; 70% by breast conservation. On the baseline MRI, 70% had mild or moderate BPE; whereas, on the follow-up study, the majority (59%) had minimal BPE. Most BPE reductions were by 2 degrees. In the baseline study, additional biopsies were required in 59% of cases, and in 17%, a short-term follow-up was recommended. In the follow-up study, biopsies were recommended in 10%, and a short-term follow-up was requested in 16%. A correlation between progesterone receptor intensity index and baseline BPE level was observed (r = 0.3, p = 0.004). CONCLUSION: ILC patients usually exhibit high BPE. ET decreases BPE, and therefore may decrease false-positive interpretations. Additional research is needed to explore whether study can be performed on ET without compromising sensitivity. Key points: ∙ High background parenchymal enhancement levels reduces breast MRI sensitivity, yielding high false positive rates especially when reporting cases of invasive lobular carcinoma [ILC]. ∙Treatment of ILC with endocrine therapy reduces background parenchymal enhancement and thus could decrease these false-positive interpretations.
Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions
Authors: Agüera-Ortiz Luis , Babulal Ganesh M. , Bruneau Marie-Andrée , Creese Byron , D’Antonio Fabrizia , Fischer Corinne E. , Gatchel Jennifer R. , Ismail Zahinoor , Kumar Sanjeev , McGeown William J. , Mortby Moyra E. , Nuñez Nicolas A. , de Oliveira Fabricio F. , Pereiro Arturo X. , Ravona-Springer Ramit , Rouse Hillary J. , Wang Huali , Lanctôt Krista L.
Published: July 2022

Psychotic phenomena are among the most severe and disruptive symptoms of dementias and appear in 30% to 50% of patients. They are associated with a worse evolution and great suffering to patients and caregivers. Their current treatments obtain limited results and are not free of adverse effects, which are sometimes serious. It is therefore crucial to develop new treatments that can improve this situation. We review available data that could enlighten the future design of clinical trials with psychosis in dementia as main target. Along with an explanation of its prevalence in the common diseases that cause dementia, we present proposals aimed at improving the definition of symptoms and what should be included and excluded in clinical trials. A review of the available information regarding the neurobiological basis of symptoms, in terms of pathology, neuroimaging, and genomics, is provided as a guide towards new therapeutic targets. The correct evaluation of symptoms is transcendental in any therapeutic trial and these aspects are extensively addressed. Finally, a critical overview of existing pharmacological and non-pharmacological treatments is made, revealing the unmet needs, in terms of efficacy and safety. Our work emphasizes the need for better definition and measurement of psychotic symptoms in dementias in order to highlight their differences with symptoms that appear in non-dementing diseases such as schizophrenia. Advances in neurobiology should illuminate the development of new, more effective and safer molecules for which this review can serve as a roadmap in the design of future clinical trials.
Electromagnetic modeling and experimental study of can-effect on a canned switched reluctance machine
Authors: Tian Lisi , Xu Biyue , Yu Qiang , Tang Chaoquan
Published: July 2022

This paper proposes a novel electromagnetic modelling method, with experimental study of the magnetic can-shield effect, based on a novel canned switched reluctance machine. Such model considers the characteristic electromagnetic coupling relation between magnetic flux and eddy current on cans, with harmonic analysis by analytical calculation in vector form. The model is structured with multiple concentrated layers in cylindrical coordinate and the main modeling process includes domain solution of the magnetic field, and an energy vector deduction for loss and energy. Comparative measurement with an indirect method demonstrates the electromagnetic features by the use of cans and meanwhile verifies the analytical model.
Free access to emergency oral contraceptives (EOCs) in the European Union: A regulatory vacuum to be filled
Authors: Cioffi Andrea , Cecannecchia Camilla , Cioffi Fernanda , Rinaldi Raffaella , Bolino Giorgio
Published: July 2022

BACKGROUND: According to the World Health Organization (WHO), any woman in childbearing age who have decided not to take permanently an oral contraceptive but who are sexually active has the right to access emergency contraception (EC). Despite this, in many European countries there are no specific laws governing the criteria for access to emergency oral contraceptives (EOCs) for girls under 18, especially about the need for third party consent. This normative vacuum is dangerous as it risks creating confusion and entrusting the management of the fundamental right of self-determination to the discretion of others. Moreover, in European Union (EU) countries, there is an inequality in terms of access to contraceptive supplies, reimbursement criteria and the availability of information online. OBJECTIVE: Our article compares the criteria for access to EOCs (Ulipristal Acetate-UPA and Levonorgestrel-LNG) in the various EU countries to highlight possible disparities and consequent inequalities. METHODS: Government and ministerial websites, European agencies websites, and Contraceptive Use by Method 2019 (WHO) have been consulted. RESULTS: There are some differences between the various European countries that could configure inequality in EU countries. CONCLUSIONS: It would be appropriate a definitive levelling of the legislation of the European Union on emergency contraception associated with massive information and awareness campaigns.
THE ROLE OF SILICATE FILLERS ON THE FORMATION PROPERTIES OF POWDER COATINGS
Authors: GOTS Volodymyr , LASTIVKA Oles , TOMIN Oleksandr , MEHET Vyacheslav
Published: July 2022

The current state of the Ukrainianeconomy causes to resolve a range of questions related to the improvement of production and increasein the ecological safety of products, including paintand-varnishes materials, in combination with ensuring high operational properties of coatings based onthem.The formation of high-quality paints and varnishes with a long service life without compromising the ecology of the environment when usingthem, is largely determined by the composition andphysical and mechanical properties of paints andvarnishes.The main disadvantage of using liquid paints andvarnishes traditional for the Ukrainian market rangeis the content of solvents in their composition up to40%, which inevitably leads to their emission during production and application, as well as environmental pollution. This problem can be solved byscaling up production using eco-friendly powdercoating.According to the research results, we have obtained eco-friendly paint-and-varnishes coatings ofhigh corrosion resistance based on powder coatingcontaining silicates as a filler in the form of metakaolin and talc.Using the mentioned range of fillers in the powder coating contributes to the decrease in the peelingwidth to 2.13 mm and metal corrosion width to 1.38mm after testing in the salt spray chamber with thecondensation of 5 % of the sodium chloride watersolution and places obtained coatings into atmospheric corrosivity categories С3 and С4 accordingto ІSO 12944-2:2017, which creates conditions forusing these compositions in the context of the excessive corrosivity.
El derecho de los trabajadores a la información sobre el algoritmo y el interés corporativo como fuente de opacidad
Authors: Padilla Parga Roberto
Published: July 2022

En la medida que los ordenamientos comienzan a apuntar a la transparencia en la toma de decisiones automatizadas como forma de protección de las personas que puedan ser objeto de dichas determinaciones, comienza a perfilarse la necesidad de analizar cómo estas herramientas se concilian con otros bienes jurídicos que puedan verse afectados por ellas. En este texto se analiza el secreto empresarial como fuente de opacidad, revisando el vínculo de aquel con la vigencia del principio de buena fe en el Derecho del Trabajo y contrastándolo con el derecho de información de los trabajadores sobre el algoritmo, mirando el ejemplo de la Ley Rider en España, buscando evidenciar que desde dicha perspectiva se permite tanto el acceso a la información como se asegura la protección de los intereses empresariales.