bluuebunny/crossref_metadata_2025 huggingface dataset:
Structure Based Multitargeted Molecular Docking Analysis of Selected Furanocoumarins against Breast Cancer
Authors: Acharya Reetuparna , Chacko Shinu , Bose Pritha , Lapenna Antonio , Pattanayak Shakti Prasad
Published: October 2019

Breast cancer is one of the biggest global dilemmas and its current therapy is to target the hormone receptors by the use of partial agonists/antagonists. Potent drugs for breast cancer treatment are Tamoxifen, Trastuzumab, Paclitaxel, etc. which show adverse effects and resistance in patients. The aim of the study has been on certain phytochemicals which has potent actions on ERα, PR, EGFR and mTOR inhibition. The current study is performed by the use of molecular docking as protein-ligand interactions play a vital role in drug design. The 3D structures of ERα, PR, EGFR and mTOR were obtained from the protein data bank and docked with 23 3D PubChem structures of furanocoumarin compounds using FlexX. Drug-likeness property was checked by applying the Lipinski’s rule of five on the furanocoumarins to evaluate anti-breast cancer activity. Antagonist and inhibition assay of ERα, EGFR and mTOR respectively has been performed using appropriatein-vitrotechniques. The results confirm that Xanthotoxol has the best docking score for breast cancer followed by Bergapten, Angelicin, Psoralen and Isoimperatorin. Further, thein-vitroresults also validate the molecular docking analysis. This study suggests that the selected furanocoumarins can be further investigated and evaluated for breast cancer treatment and management strategies.
Exhaled volatile substances in children suffering from type 1 diabetes mellitus: results from a cross-sectional study
Authors: Trefz Phillip , Obermeier Juliane , Lehbrink Ruth , Schubert Jochen K. , Miekisch Wolfram , Fischer Dagmar-Christiane
Published: October 2019

Monitoring metabolic adaptation to type 1 diabetes mellitus in children is challenging. Analysis of volatile organic compounds (VOCs) in exhaled breath is non-invasive and appears as a promising tool. However, data on breath VOC profiles in pediatric patients are limited. We conducted a cross-sectional study and applied quantitative analysis of exhaled VOCs in children suffering from type 1 diabetes mellitus (T1DM) (n = 53) and healthy controls (n = 60). Both groups were matched for sex and age. For breath gas analysis, a very sensitive direct mass spectrometric technique (PTR-TOF) was applied. The duration of disease, the mode of insulin application (continuous subcutaneous insulin infusion vs. multiple daily insulin injection) and long-term metabolic control were considered as classifiers in patients. The concentration of exhaled VOCs differed between T1DM patients and healthy children. In particular, T1DM patients exhaled significantly higher amounts of ethanol, isopropanol, dimethylsulfid, isoprene and pentanal compared to healthy controls (171, 1223, 19.6, 112 and 13.5 ppbV vs. 82.4, 784, 11.3, 49.6, and 5.30 ppbV). The most remarkable differences in concentrations were found in patients with poor metabolic control, i.e. those with a mean HbA1c above 8%. In conclusion, non-invasive breath testing may support the discovery of basic metabolic mechanisms and adaptation early in the progress of T1DM.
3D Porous Graphene Based Aerogel for Electromagnetic Applications
Authors: Cheraghi Bidsorkhi Hossein , D’Aloia Alessandro Giuseppe , Tamburrano Alessio , De Bellis Giovanni , Delfini Andrea , Ballirano Paolo , Sarto Maria Sabrina
Published: October 2019

Lightweight multifunctional electromagnetic (EM) absorbing materials with outstanding thermal properties, chemical resistance and mechanical stability are crucial for space, aerospace and electronic devices and packaging. Therefore, 3D porous graphene aerogels are attracting ever growing interest. In this paper we present a cost effective lightweight 3D porous graphene-based aerogel for EM wave absorption, constituted by a poly vinylidene fluoride (PVDF) polymer matrix filled with graphene nanoplatelets (GNPs) and we show that the thermal, electrical, mechanical properties of the aerogel can be tuned through the proper selection of the processing temperature, controlled either at 65 °C or 85 °C. The produced GNP-filled aerogels are characterized by exceptional EM properties, allowing the production of absorbers with 9.2 GHz and 6.4 GHz qualified bandwidths with reflection coefficients below −10 dB and −20 dB, respectively. Moreover, such aerogels show exceptional thermal conductivities without any appreciable volume change after temperature variations. Finally, depending on the process parameters, it is shown the possibility to obtain water repellent aerogel composites, thus preventing their EM and thermal properties from being affected by environmental humidity and allowing the realization of EM absorber with a stable response.
High-performance Acetone Soluble Tape Transfer Printing Method for Heterogeneous Integration
Authors: Zhang Jiaqi , Wu Yichang , Li Zhe , Zhang Yachao , Peng Yue , Chen Dazheng , Zhu Weidong , Xu Shengrui , Zhang Chunfu , Hao Yue
Published: October 2019

A high-performance transfer printing method using a new soluble tape which can be dissolved in acetone is proposed to be used in heterogeneous integration. Si inks array was transferred from SOI wafers onto various substrates without adhesion promoter by this new method which we refer to as the acetone soluble tape (AST) method to compare with other transfer printing methods by using thermal release tape (TRT), water soluble tape (WST) and polydimethylsiloxane (PDMS). By using the AST method, the transfer printing process does not involve interface contention between stamp/inks and inks/receiver substrate so that it maximizes the transfer printing efficiency. Experimental results present the AST method has good performances, and various alien substrates, even curvilinear surfaces, can be selected as receiver substrates by the AST method. To examine the quality of the transferred Si inks, the Si TFTs were fabricated by using the Si membrane transferred by the AST method on sapphire substrate and the devices show the good performance. All the results confirm that the AST method is an effective method in heterogeneous integration.
Targeting ERβ in Macrophage Reduces Crown-like Structures in Adipose Tissue by Inhibiting Osteopontin and HIF-1α
Authors: Wang Li , Zhao Rui-peng , Song Xiao-yu , Wu Wan-fu
Published: October 2019

Proinflammatory processes in adipose tissue contribute to development of breast cancer and insulin resistance. Crown-like structures (CLS) are histologic hallmarks of the proinflammatory process in adipose tissue. CLS are microscopic foci of dying adipocytes surrounded by macrophages mostly derived from monocytes in blood. Estrogen receptor β (ERβ) is expressed in microglia, macrophages within the central nervous system (CNS), where it evokes an anti-inflammatory response. The present study investigates the function of ERβ in macrophages within CLS. We report that even though monocytes in the blood have no detectable levels of ERβ, macrophages in CLS do express ERβ. In ERβ−/− mice, there was a significant increase in the number of CLS in both subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT). CLS in these mice were dominated by pro-inflammatory macrophages (M1 macrophages) with higher expression of osteopontin (OPN) and an increase in number of proliferating macrophages. In mice made obese by Western diet, treatment with an ERβ selective agonist (LY3201) reduced the number of CLS in both SAT and VAT with downregulation of OPN, activated hypoxia-inducible factor-1α (HIF-1α), proliferation and upregulation prolyl hydroxylase 2 (PHD2), the enzyme which prevents activation of HIF1α, in macrophages. We conclude that ERβ expression is induced in macrophages in CLS within adipose tissue where it plays a pivotal role in suppression of CLS. Thus ERβ agonists may be used to alleviate CLS-related breast cancer and insulin resistance in adipose tissue.
Establishment of an induced pluripotent cell line from Taiwan black silkie chick embryonic fibroblasts for replication-incompetent virus production
Authors: Liou Jenn-Fa , Wu Wen-Ren , Chen Lih-Ren , Shiue Yow-Ling
Published: October 2019

The objective of this study was to establish a versatile cell line for replication-incompetent virus production and inactivation with formaldehyde to generate a model of cell-based vaccine manufacturing process. To achieve this goal, we took advantage of the easily accessed chick embryonic fibroblasts. Nine-day old chick embryonic fibroblasts were obtained and subjected to be transduced with a set of lentivirus to develop a chick induced pluripotent stem (ciPS) cell line. Morphological features, positive periodic acid-Schiff staining as well as strong immunocytofluorescence of alkaline phosphatase, intestinal (ALPI) and POU class 5 homeobox 1 (POU5F1) proteins suggested that these chick embryonic fibroblasts have been transformed into ciPS cells. Further differentiation and immunocytofluorescence assays confirmed that this ciPS cell line possesses capacities and potentials to form embryoid bodies, differentiate into all three embryonic layers: ectoderm, mesoderm and endoderm with evidence of strongly positive and specific molecular markers. Immunoblot analysis next demonstrated that through recombinant DNA technology and the 2nd generation lentiviral transfer system, the goose hemagglutinin gene (H5) gene was packaged into the replication-incompetent virus and highly expressed in a bladder cancer-derived cell line, T24, after transduction. The titer of ciPS-generated replication-incompetent virus is comparable to that from the Phoenix-AMPHO cell line, which is a commercial and high productive retrovirus producer. Our study successfully established a ciPS cell line which is able to produce replication-incompetent virus, providing a new strategy for cell-based vaccine production after virus inactivation.
Oct4-mediated reprogramming induces embryonic-like microRNA expression signatures in human fibroblasts
Authors: Peskova Lucie , Cerna Katerina , Oppelt Jan , Mraz Marek , Barta Tomas
Published: October 2019

Oct4-mediated reprogramming has recently become a novel tool for the generation of various cell types from differentiated somatic cells. Although molecular mechanisms underlying this process are unknown, it is well documented that cells over-expressing Oct4 undergo transition from differentiated state into plastic state. This transition is associated with the acquisition of stem cells properties leading to epigenetically “open” state that is permissive to cell fate switch upon external stimuli. In order to contribute to our understanding of molecular mechanisms driving this process, we characterised human fibroblasts over-expressing Oct4 and performed comprehensive small-RNAseq analysis. Our analyses revealed new interesting aspects of Oct4-mediated cell plasticity induction. Cells over-expressing Oct4 lose their cell identity demonstrated by down-regulation of fibroblast-specific genes and up-regulation of epithelial genes. Interestingly, this process is associated with microRNA expression profile that is similar to microRNA profiles typically found in pluripotent stem cells. We also provide extensive network of microRNA families and clusters allowing us to precisely determine the miRNAome associated with the acquisition of Oct4-induced transient plastic state. Our data expands current knowledge of microRNA and their implications in cell fate alterations and contributing to understanding molecular mechanisms underlying it.
Phylogenetic evidence of the intercontinental circulation of a Canine distemper virus lineage in the Americas
Authors: Duque-Valencia July , Forero-Muñoz Norma R. , Díaz Francisco J. , Martins Elisabete , Barato Paola , Ruiz-Saenz Julian
Published: October 2019

Canine distemper virus (CDV) is the cause of a multisystem disease in domestic dogs and wild animals, infecting more than 20 carnivore and non-carnivore families and even infecting human cell lines in in vitro conditions. Phylogenetic classification based on the hemagglutinin gene shows 17 lineages with a phylogeographic distribution pattern. In Medellín (Colombia), the lineage South America-3 is considered endemic. Phylogenetic studies conducted in Ecuador using fragment coding for the fusion protein signal peptide (Fsp) characterized a new strain belonging to a different lineage. For understanding the distribution of the South America-3 lineage in the north of the South American continent, we characterized CDV from three Colombian cities (Medellín, Bucaramanga, and Bogotá). Using phylogenetic analysis of the hemagglutinin gene and the Fsp region, we confirmed the circulation of CDV South America-3 in different areas of Colombia. We also described, for the first time to our knowledge, the circulation of a new lineage in Medellín that presents a group monophyletic with strains previously characterized in dogs in Ecuador and in wildlife and domestic dogs in the United States, for which we propose the name “South America/North America-4” due its intercontinental distribution. In conclusion, our results indicated that there are at least four different CDV lineages circulating in domestic dogs in South America: the Europe/South America-1 lineage circulating in Brazil, Uruguay, and Argentina; the South America-2 lineage restricted to Argentina; the South America-3 lineage, which has only been reported in Colombia; and lastly an intercontinental lineage present in Colombia, Ecuador, and the United States, referred to here as the “South America/North America-4” lineage.
Intracluster proton transfer in protonated benzonitrile–(H2O)n≤6 nanoclusters: hydrated hydronium core for n ≥ 2
Authors: Chatterjee Kuntal , Dopfer Otto
Published: October 2019

Infrared spectroscopy and density functional theory calculations of protonated benzonitrile–(H2O)n clusters reveal proton transfer to solvent for n ≥ 2 and the drastic effects of the aromatic dopant molecule on the network of H+(H2O)n+1.
Triethylamine-templated nanocalix Ln12 clusters of diacylhydrazone: crystal structures and magnetic properties
Authors: Luo Zhi-Rong , Zou Hua-Hong , Chen Zi-Lu , Li Bo , Wang Kai , Liang Fu-Pei
Published: October 2019

Three {Ln12} (Ln = Gd (1), Tb (2), Dy (3)) nanocalix clusters with a novel ligand of N,N′-bis(o-vanillidene)-1H-imidazole-4,5-dicarbohydrazide (H5ovih) were synthesized via the amine-templating strategy.
Evidence for a kinetically controlled burying mechanism for growth of high viscosity secondary organic aerosol
Authors: Vander Wall Allison C. , Perraud Véronique , Wingen Lisa M. , Finlayson-Pitts Barbara J.
Published: October 2019

The incorporation of organic nitrates into viscous secondary organic aerosol during particle formation is enhanced relative to expected equilibrium partitioning, and is best described by a kinetically controlled “burying” mechanism.
The atmospheric chemistry of indoor environments
Authors: Abbatt Jonathan P. D. , Wang Chen
Published: October 2019

The review article summarizes the wide variety of atmospheric chemistry phenomena that occur indoors.
Lipid digestion of oil-in-water emulsions stabilized with low molecular weight surfactants
Authors: Ng Natalie , Chen Peter X. , Ghazani Saeed M. , Wright Amanda J. , Marangoni Alejandro , Goff H. Douglas , Joye Iris J. , Rogers Michael A.
Published: October 2019

Altering sn-fatty acid position of glycerol mono-oleate (GMO) from sn-1 to sn-2 decreases fatty acid bioaccessibility by 25.9% providing possible strategies to tailor lipemic responses of food emulsions.
A bio-pen for direct writing of single molecules on user-functionalized surfaces
Authors: Hu Xiao , Dinu Cerasela Zoica
Published: October 2019

Single kinesin molecules printed onto a user-functionalized substrate using biological pens.
Predicting structure/property relationships in multi-dimensional nanoparticle data using t-distributed stochastic neighbour embedding and machine learning
Authors: Barnard A. S. , Opletal G.
Published: October 2019

Visualization can be a useful precursor to quantitative machine learning methods for uncovering structure/property relationships.
Real-time imaging of individual virion-triggered cortical actin dynamics for human immunodeficiency virus entry into resting CD4 T cells
Authors: Yin Wen , Li Wei , Li Qin , Liu Yuanyuan , Liu Ji , Ren Min , Ma Yingxin , Zhang Zhiping , Zhang Xiaowei , Wu Yuntao , Jiang Shibo , Zhang Xian-En , Cui Zongqiang
Published: October 2019

Using QD-encapsulated HIV particles and single-virus tracking, we revealed virus-regulated cortical actin dynamics during HIV entry into CD4 T cells.
G-quadruplexes as versatile scaffolds for catalysis
Authors: Yum Ji Hye , Park Soyoung , Sugiyama Hiroshi
Published: October 2019

This review summarizes the beginning, progress, and prospects of non-canonical DNA-based hybrid catalysts focusing on G-quadruplexes as versatile scaffolds for catalysis.
Imidates: an emerging synthon for N-heterocycles
Authors: Thakur Rima , Jaiswal Yogesh , Kumar Amit
Published: October 2019

This review highlights the recent application of imidates as building blocks for the synthesis of saturated and un-saturated N-heterocycles via C–N annulation reactions under acid/base/metal-catalyzed/radical-mediated reaction conditions.
Total chemical synthesis of murine ISG15 and an activity-based probe with physiological binding properties
Authors: Xin Bo-Tao , Gan Jin , Fernandez Daniel J. , Knobeloch Klaus-Peter , Geurink Paul P. , Ovaa Huib
Published: October 2019

The linear synthesis of the N-terminal domain of mISG15 has been developed which enables the synthesis of full-length mISG15 and the activity-based probe Rho-mISG15-PA via native chemical ligation.
Bioremediation of petroleum hydrocarbon-contaminated soil by petroleum-degrading bacteria immobilized on biochar
Authors: Zhang Bofan , Zhang Liang , Zhang Xiuxia
Published: October 2019

The immobilization of bacteria on biochar was effective in reducing TPHs, n-alkanes with C12–18 and maintaining the balance of the soil ecosystem.
Interaction and thermal studies on graphene oxide in NC/DEGDN/GO nanocomposites
Authors: Yahya Prima Kharisma Indra , Moniruzzaman Mohammed , Gill Philip P.
Published: October 2019

Before considering the use of graphene oxide (GO) in nitrate ester-based materials for improved safety and performance its interaction, compatibility, and dispersion with the host matrices needs to be well understood.
Grafting metal complexes onto amorphous supports: from elementary steps to catalyst site populationsviakernel regression
Authors: Khan Salman A. , Vandervelden Craig A. , Scott Susannah L. , Peters Baron
Published: October 2019

We use transition state theory, kernel regression, and population balance modeling techniques to model the grafting of metal complexes onto amorphous catalyst supports.
Gravity-driven syneresis in model low-fat mayonnaise
Authors: Wu Qimeng , Punter Melle T. J. J. M. , Kodger Thomas E. , Arnaudov Luben , Mulder Bela M. , Stoyanov Simeon , van der Gucht Jasper
Published: October 2019

We show that forced syneresis in model low fat mayonnaise, a colloid polymer mixture, can be described as a gravity-driven porous flow through the densely packed emulsion, explainable with a model based on Darcy's law.
Rotating oil droplets driven by motile bacteria at interfaces
Authors: Dewangan Narendra K. , Conrad Jacinta C.
Published: October 2019

Oil droplets suspended near a liquid–solid interface can be driven to rotate by motile bacteria adhered to the droplet surface.
Electric field-induced crossover from 3D to 2D topological defects in a nematic liquid crystal: experimental verification
Authors: Ferris Andrew J. , Afghah Sajedeh , Selinger Robin L. B. , Selinger Jonathan V. , Rosenblatt Charles
Published: October 2019

A substrate was patterned with two pairs of half-integer strength topological defects, (+1/2, +1/2) and (+1/2, −1/2).
Bioengineering tunable porosity in bacterial nanocellulose matrices
Authors: Ashrafi Zahra , Lucia Lucian , Krause Wendy
Published: October 2019

Our work provides the first accounting of how specific culture conditions, i.e., carbon nutrient sources, control morphological and physical properties in bacterial cellulose filaments.
Bio-based thermoplastic poly(butylene succinate-co-propylene succinate) copolyesters: effect of glycerol on thermal and mechanical properties
Authors: Hsu Kai-Hung , Chen Chin-Wen , Wang Li-Yuan , Chan Hao-Wei , He Cyuan-Lun , Cho Chia-Jung , Rwei Syang-Peng , Kuo Chi-Ching
Published: October 2019

The thermal and mechanical properties of the bio-based thermoplastic copolyesters can be controlled by adjusting the glycerol content and this allows the use of such copolyesters in medical support, and coating on 3D fabrics applications.
Niobium disulphide (NbS2)-based (heterogeneous) electrocatalysts for an efficient hydrogen evolution reaction
Authors: Najafi Leyla , Bellani Sebastiano , Oropesa-Nuñez Reinier , Martín-García Beatriz , Prato Mirko , Mazánek Vlastimil , Debellis Doriana , Lauciello Simone , Brescia Rosaria , Sofer Zdeněk , Bonaccorso Francesco
Published: October 2019

The development of niobium disulphide (NbS2)-based heterogeneous electrocatalysts for an efficient hydrogen evolution reaction.
A universal KOH-free strategy towards nitrogen-doped carbon nanosheets for high-rate and high-energy storage devices
Authors: Yuan Gang , Huang Wanwen , Guan Kaixiu , Li Huimin , Xie Yingjun , Liang Yeru , Liu Yingliang , Zheng Mingtao
Published: October 2019

A universal KOH-free strategy is developed to prepare nitrogen-doped carbon nanosheets (N-SCNSs) derived from edible oil residues with high specific surface area and high nitrogen content for application in high-rate and high-energy supercapacitors.
The enhanced photoluminescence and temperature sensing performance in rare earth doped SrMoO4 phosphors by aliovalent doping: from material design to device applications
Authors: Zhang Hui , Zhao Shilong , Wang Xiuli , Ren Xiaotong , Ye Jiatao , Huang Lihui , Xu Shiqing
Published: October 2019

Simultaneous enhancement of upconversion luminescence and temperature sensitivity are achieved by aliovalent doping in Er3+/Yb3+ codoped SrMoO4 phosphors and a highly accurate all-fiber ratiometric temperature sensing platform has been constructed.
Enabling superior stretchable resistive switching memory via polymer-functionalized graphene oxide nanosheets
Authors: Hou Jie , Zhang Bin , Li Dongqi , Fu Yubin , Liu Gang , Chen Yu
Published: October 2019

Overlapping and intercalated graphene oxide nanosheets, covalently modified with electroactive polymers, are employed to enable stretchable resistive switching memory with superior electrical bistability and deformation capability.
Metabolomics study of fasudil on cisplatin-induced kidney injury
Authors: Xia Demeng , Lai Xueli , Wu Kaiwen , Zhou Panyu , Li Lei , Guo Zhiyong , Xu Shuogui
Published: October 2019

Fasudil is a derivative of 5-isoquinoline sulfonamide, which is a Rho kinase inhibitor, a wide range of pharmacological effects. Fasudil has been shown to attenuate kidney injury caused by certain substances. In the present study, metabolomic analysis of mouse kidney tissues ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry was used to determine the metabolomic changes in cisplatin-induced kidney injury and the fasudil-induced attenuation of cisplatin-induced kidney injury. Metabolomic profiling of kidney tissues revealed significant differences in metabolites between the control group and the cisplatin group and between the cisplatin group and the fasudil-intervention group. With metabolomic approach, 68 endogenous differential metabolites were found, and multivariate statistical analysis, accurate molecular weights, isotope tracers, mass-spectrometry secondary-fragment information, and standard-reference comparisons were used to identify these substances. Based on these differential metabolites, a metabolic-pathway network was constructed and revealed that fasudil primarily attenuated cisplatin-induced renal injury by modulating lipid and amino-acid metabolism. These results further demonstrate that kidney injury can be induced by cisplatin and, moreover, suggest that fasudil can be used to reduce kidney injury at early stages in patients treated with cisplatin.
DDS‐based protocol‐compatible communication platform for mining power system
Authors: Fang Shuhua , Huang Lei , Li Zhongjie
Published: October 2019

Currently, mine protectors have different communication protocols, which make them difficult to communicate with each other due to their heterogeneity. In order to solve the problem, this study proposes a structure based on data distribution service (DDS) between substation and different mine protectors, which unifies the different protocols for devices to DDS protocol. A DDS platform is built to transmit electrical parameters between devices using different protocols with appropriate quality of service strategies. The communication between IEC 60870‐103 protocol and Modbus protocol is carried out on laptop and Raspberry Pi. The proposed DDS platform implements its normal communication between different protocols and the latency can meet the requirement of mine protectors. The experimental results verify that DDS can reduce the heterogeneity of mining power system.
Development of a wind turbine simulator
Authors: Sun Yuan , Zhang Ji , Zhou Yanru
Published: October 2019

As a renewable energy source, wind power has become a hot research topic, despite the lack of wind‐environment simulation equipment in most laboratories. To address this shortcoming, this paper developed equipment based on a DC motor to simulate wind turbines. The reference torque is determined by the operational parameters of the wind turbine. The DC‐motor speed is regulated by using DC pulse‐width modulation, so that the output characteristics of the DC motor may be tuned to be equivalent to those of the wind turbine. A dsPIC30F2010‐microcontroller‐based hardware platform is used in experiments to verify the effectiveness of the proposed approach.
Construction of integrated land‐space loss prevention and crime prevention system of prison
Authors: Qi Xia , Feng Dengchao , Luo Junjie
Published: October 2019

Britain, in addition to its airports, has suffered from drone attacks in its prisons. Suspects use drones to transport contraband such as drugs or cell phones to inmates in a new challenge to British prison safety. In China, the means of manpower prevention, physical protection, technical prevention are comprehensively applied, the integrated loss prevention and crime prevention system of land‐space is the guarantee of prison safety. Firstly, the integrated loss prevention and crime prevention system of air and land is devoted to the construction of intelligent video surveillance system, the personnel location management, the cooperation and information sharing between video surveillance technology and management system, and the perfection of ‘low, slow’ in the low altitude airspace of the prison. Small ‘aircraft’ and other systems, such as timely early warning, all‐weather monitoring, strong expulsion and safety capture, combine the two information together to build a model of accurate information, rapid organisation, well‐informed decision‐making, well‐managed and effective safety and prevention, to ensure the safety of the prison.
X‐parameter modelling of GaN HEMT based on neural network
Authors: Lei Niu , Jiang Feiyan , Sun Lu
Published: October 2019

Currently, S‐parameters are commonly used in the design, measurement, and modelling of microwave circuits, but it is only suitable for linear small‐signal conditions and not suitable for large‐signal conditions. X‐parameter is more accurate than the S‐parameter in characterising the non‐linearity of the device or the microwave circuit, and the artificial neural network has significant advantages in predicting the non‐linearity of the system. Based on theoretical analysis, this article selects the GaN HEMT device CGH40010F for X‐parameter modelling. Using X‐parameter generator of ADS software, the X‐parameters of the device were obtained. An X‐parameter model based on BP neural network was built using MATLAB neural network box. The accuracy of the model was verified by comparing the test data with the model prediction data.
Remote parameters tuning system based on simplex‐search‐based model‐free optimisation for motor speed control
Authors: Kong Xiangsong , Tang Zeyu , Zhu Yisheng , Xiao Yining , Shen Qinghang , Jiang Shaobo
Published: October 2019

Motor is a very widely used control device in industry. The performance of a motor speed control system is very critical for its application. The control performance can be improved through control parameters tuning. However, the parameters tuning process is difficult to implement online automatically. The traditional parameters tuning methods for a motor control system are usually experience‐based, cumbersome and time‐consuming. In this study, taking advantage of the high computation ability of the MATLAB, a remote motor control system framework based on the wireless network was proposed. The simplex‐search‐based model‐free optimisation (MFO) was developed based on the MATLAB platform to optimise the control parameters. With this optimisation methodology, the performance of the control system can be improved iteratively by directly using measurements of the control performance online. This system has been realised and tested systematically. The effectiveness and the efficiency have been demonstrated by a series of experiments.
Deep point spread function photometric catalog of the VVV survey data
Authors: Zhang M. , Kainulainen J.
Published: October 2019

Context. The Vista Variables in the Vía Láctea (VVV) survey has performed a multi-epoch near-infrared imaging of the inner Galactic plane. High-fidelity photometric catalogs are needed to utilize the data.

Aims. We aim at producing a deep, point spread function (PSF) photometric catalog for the VVV survey J-,H-, and Ks-band data. Specifically, we aim to take advantage of multiple epochs of the survey to reach high limiting magnitudes.

Methods. We developed an automatic PSF-fitting pipeline based on the DaoPHOT algorithm and performed photometry on the stacked VVV images in J,  H, and Ks bands.

Results. We present a PSF photometric catalog in the Vega system that contains about 926 million sources in the J,  H, and Ks filters. About 10% of the sources are flagged as possible spurious detections. The 5σ limiting magnitudes of the sources with high reliability are about 20.8, 19.5, and 18.7 mag in the J,  H, and Ks bands, respectively, depending on the local crowding condition. Our photometric catalog reaches on average about one magnitude deeper than the previously released PSF DoPHOT photometric catalog and includes less spurious detections. There are significant differences in the brightnesses of faint sources between our catalog and the previously released one. The likely origin of these differences is in the different photometric algorithms that are used; it is not straightforward to assess which catalog is more accurate in different situations. Our new catalog is beneficial especially for science goals that require high limiting magnitudes; our catalog reaches such high magnitudes in fields that have a relatively uniform source number density. Overall, the limiting magnitudes and completeness are different in fields with different crowding conditions.
Fast quasi-periodic oscillations in the eclipsing polar VV Puppis from VLT and XMM-Newton observations
Authors: Bonnet-Bidaud J. M. , Mouchet M. , Falize E. , Van Box Som L. , Busschaert C. , Buckley D. A. H. , Breytenbach H. , Marsh T. R. , Ashley R. P. , Dhillon V. S.
Published: October 2019

We present high time resolution optical photometric data of the polar VV Puppis obtained simultaneously in three filters (u′, HeII λ4686, r′) with the ULTRACAM camera mounted at the ESO-VLT telescope. An analysis of a long 50 ks XMM-Newton observation of the source, retrieved from the database, is also provided. Quasi-periodic oscillations (QPOs) are clearly detected in the optical during the source bright phase intervals when the accreting pole is visible, confirming the association of the QPOs with the basis of the accretion column. QPOs are detected in the three filters at a mean frequency of ∼0.7 Hz with a similar amplitude ∼1%. Mean orbitally-averaged power spectra during the bright phase show a rather broad excess with a quality factor Q = ν/Δν = 5−7 but smaller data segments commonly show a much higher coherency with Q up to 30. The X-ray Multi-mirror Mission XMM (0.5–10 keV) observation provides the first accurate estimation of the hard X-ray component with a high kT ∼ 40 keV temperature and confirms the high extreme ultraviolet (EUV)-soft/hard ratio in the range of 4−15 for VV Pup. The detailed X-ray orbital light curve displays a short Δϕ ≃ 0.05 ingress into self-eclipse of the active pole, indicative of an accretion shock height of ∼75 km. No significant X-ray QPOs are detected with an amplitude upper limit of ∼30% in the range 0.1–5 Hz. Detailed hydrodynamical numerical simulations of the post-shock accretion region with parameters consistent with VV Pup demonstrate that the expected frequencies from radiative instability are identical for X-rays and optical regime at values ν ∼ 40–70 Hz, more than one order magnitude higher than observed. This confirms previous statements suggesting that present instability models are unable to explain the full QPO characteristics within the parameters commonly known for polars.
Polarisation of a small-scale cometary plasma environment
Authors: Gunell Herbert , Lindkvist Jesper , Goetz Charlotte , Nilsson Hans , Hamrin Maria
Published: October 2019

Context.The plasma near the nucleus of a comet is subjected to an electric field to which a few different sources contribute: the convective electric field of the solar wind, the ambipolar electric field due to higher electron than ion speeds, and a polarisation field arising from the vastly different ion and electron trajectories.

Aims.Our aim is to show how the ambipolar and polarisation electric fields arise and develop under the influence of space charge effects, and in doing so we paint a qualitative picture of the electric fields in the inner coma of a comet.

Methods.We use an electrostatic particle-in-cell model to simulate a scaled-down comet, representing comet 67P/Churyumov-Gerasimenko with parameters corresponding to a 3.0 AU heliocentric distance.

Results.We find that an ambipolar electric field develops early in the simulation and that this is soon followed by the emergence of a polarisation electric field, manifesting itself as an anti-sunward component prevalent in the region surrounding the centre of the comet. As plasma is removed from the inner coma in the direction of the convectional electric field of the solar wind, a density maximum develops on the opposite side of the centre of the comet.

Conclusions.The ambipolar and polarisation electric fields both have a significant influence on the motion of cometary ions. This demonstrates the importance of space charge effects in comet plasma physics.
Combining magnetohydrostatic constraints with Stokes profiles inversions
Authors: Borrero J. M. , Pastor Yabar A. , Rempel M. , Ruiz Cobo B.
Published: October 2019

Context. Inversion codes for the polarized radiative transfer equation, when applied to spectropolarimetric observations (i.e., Stokes vector) in spectral lines, can be used to infer the temperature T, line-of-sight velocity vlos, and magnetic field B as a function of the continuum optical-depth τc. However, they do not directly provide the gas pressure Pg or density ρ. In order to obtain these latter parameters, inversion codes rely instead on the assumption of hydrostatic equilibrium (HE) in addition to the equation of state (EOS). Unfortunately, the assumption of HE is rather unrealistic across magnetic field lines, causing estimations of Pg and ρ to be unreliable. This is because the role of the Lorentz force, among other factors, is neglected. Unreliable gas pressure and density also translate into an inaccurate conversion from optical depth τc to geometrical height z.

Aims. We aim at improving the determination of the gas pressure and density via the application of magnetohydrostatic (MHS) equilibrium instead of HE.

Methods. We develop a method to solve the momentum equation under MHS equilibrium (i.e., taking the Lorentz force into account) in three dimensions. The method is based on the iterative solution of a Poisson-like equation. Considering the gas pressure Pg and density ρ from three-dimensional magnetohydrodynamic (MHD) simulations of sunspots as a benchmark, we compare the results from the application of HE and MHS equilibrium using boundary conditions with different degrees of realism. Employing boundary conditions that can be applied to actual observations, we find that HE retrieves the gas pressure and density with an error smaller than one order of magnitude (compared to the MHD values) in only about 47% of the grid points in the three-dimensional domain. Moreover, the inferred values are within a factor of two of the MHD values in only about 23% of the domain. This translates into an error of about 160 − 200 km in the determination of the z − τc conversion (i.e., Wilson depression). On the other hand, the application of MHS equilibrium with similar boundary conditions allows determination of Pg and ρ with an error smaller than an order of magnitude in 84% of the domain. The inferred values are within a factor of two in more than 55% of the domain. In this latter case, the z − τc conversion is obtained with an accuracy of 30 − 70 km. Inaccuracies are due in equal part to deviations from MHS equilibrium and to inaccuracies in the boundary conditions.

Results. Compared to HE, our new method, based on MHS equilibrium, significantly improves the reliability in the determination of the density, gas pressure, and conversion between geometrical height z and continuum optical depth τc. This method could be used in conjunction with the inversion of the radiative transfer equation for polarized light in order to determine the thermodynamic, kinematic, and magnetic parameters of the solar atmosphere.
Three-dimensional magnetic field structure of a flux-emerging region in the solar atmosphere
Authors: Yadav Rahul , de la Cruz Rodríguez Jaime , Díaz Baso Carlos José , Prasad Avijeet , Libbrecht Tine , Robustini Carolina , Asensio Ramos Andrés
Published: October 2019

We analyze high-resolution spectropolarimetric observations of a flux-emerging region (FER) in order to understand its magnetic and kinematic structure. Our spectropolarimetric observations in the He I 10830 Å spectral region of a FER were recorded with GRIS at the 1.5 m aperture GREGOR telescope. A Milne–Eddington-based inversion code was employed to extract the photospheric information of the Si I spectral line, whereas the He I triplet line was analyzed with the Hazel inversion code, which takes into account the joint action of the Hanle and the Zeeman effects. The spectropolarimetric analysis of the Si I line reveals a complex magnetic structure near the vicinity of the FER, where a weak (350–600 G) and horizontal magnetic field was observed. In contrast to the photosphere, the analysis of the He I triplet presents a smooth variation of the magnetic field vector (ranging from 100 to 400 G) and velocities across the FER. Moreover, we find supersonic downflows of ∼40 km s−1 appearing near the foot points of loops connecting two pores of opposite polarity, whereas strong upflows of 22 km s−1 appear near the apex of the loops. At the location of supersonic downflows in the chromosphere, we observed downflows of 3 km s−1 in the photosphere. Furthermore, nonforce-free field extrapolations were performed separately at two layers in order to understand the magnetic field topology of the FER. We determine, using extrapolations from the photosphere and the observed chromospheric magnetic field, that the average formation height of the He I triplet line is ∼2 Mm from the solar surface. The reconstructed loops using photospheric extrapolations along an arch filament system have a maximum height of ∼10.5 Mm from the solar surface with a foot-point separation of ∼19 Mm, whereas the loops reconstructed using chromospheric extrapolations reach around ∼8.4 Mm above the solar surface with a foot-point separation of ∼16 Mm at the chromospheric height. The magnetic topology in the FER suggests the presence of small-scale loops beneath the large loops. Under suitable conditions, due to magnetic reconnection, these loops can trigger various heating events in the vicinity of the FER.
2I/Borisov: A C2-depleted interstellar comet
Authors: Opitom Cyrielle , Fitzsimmons Alan , Jehin Emmanuel , Moulane Youssef , Hainaut Olivier , Meech Karen J. , Yang Bin , Snodgrass Colin , Micheli Marco , Keane Jacqueline V. , Benkhaldoun Zouhair , Kleyna Jan T.
Published: October 2019

Aims.The discovery of the first active interstellar object 2I/Borisov provides an unprecedented opportunity to study planetary formation processes in another planetary system. In particular, spectroscopic observations of 2I allow us to constrain the composition of its nuclear ices.

Methods.We obtained optical spectra of 2I with the 4.2 mWilliam Herscheland 2.5 mIsaac Newtontelescopes between 2019 September 30 and October 13, when the comet was between 2.5 au and 2.4 au from the Sun. We also imaged the comet with broadband filters on 15 nights from September 11 to October 17, as well as with a CN narrow-band filter on October 18 and 20, with the TRAPPIST-North telescope.

Results.Broadband imaging confirms that the dust coma colours (B − V = 0.82 ± 0.02,V − R = 0.46 ± 0.03,R − I = 0.44 ± 0.03,B − R = 1.28 ± 0.03) are the same as for Solar System comets. We detect CN emission in all spectra and in the TRAPPIST narrow-band images with production rates between 1.6 × 1024and 2.1 × 1024molec/s. No other species are detected. We determine three-sigma upper limits for C2, C3, and OH production rates of 6 × 1023molec/s, 2 × 1023molec/s and 2 × 1027molec/s, respectively, on October 02. There is no significant increase of the CN production rate or A(0)fρduring our observing period. Finally, we place a three-sigma upper limit on the Q(C2)/Q(CN) ratio of 0.3 (on October 13). From this, we conclude that 2I is highly depleted in C2, and may have a composition similar to Solar System carbon-chain depleted comets.
Genotype identification and phylogenetic analysis ofEnterocytozoon bieneusiin farmed black goats (Capra hircus) from China’s Hainan Province
Authors: Zhou Huan-Huan , Zheng Xin-Li , Ma Tian-Ming , Qi Meng , Cao Zong-Xi , Chao Zhe , Wei Li-Min , Liu Quan-Wei , Sun Rui-Ping , Wang Feng , Zhang Yan , Lu Gang , Zhao Wei
Published: October 2019

Enterocytozoon bieneusiis an important pathogen commonly found in humans and animals. Farmed animals with close contact to humans are important hosts ofE. bieneusi. The role of goats in the transmission ofE. bieneusi, however, remains unclear. In this study, 341 fresh fecal samples of black goats were collected from five locations in Hainan Province, China.Enterocytozoon bieneusiwas identified and genotyped by sequences of the internal transcribed spacer (ITS) region. Phylogenetic analysis was performed by constructing a neighbor-joining tree of the ITS gene sequences. The average prevalence ofE. bieneusiin black goats was 24.0% (82/341) with rates ranging from 6.3% (4/63) to 37.2% (32/86) across the locations (χ2 = 17.252,p < 0.01). Eight genotypes ofE. bieneusiwere identified, including six known genotypes: CHG5 (n = 47); CHG3 (n = 23); CHG2 (n = 4); CM21 (n = 3); D (n = 2); and AHG1 (n = 1), and two novel genotypes termed HNG-I (n = 1) and HNG-II (n = 1). In the phylogenetic tree, genotype D was clustered into Group 1 and the other identified genotypes were included in Group 2. This represents the first report identifyingE. bieneusiin black goats from Hainan Province, with a high prevalence and wide occurrence demonstrated. The two new genotypes identified provide additional insights into the genotypic variations inE. bieneusi. Due to the small percentage of zoonotic genotypes in these animals, there is minimal risk of zoonotic transmission ofE. bieneusi.
Neoadjuvant cryotherapy improves dysphagia and may impact remission rates in advanced esophageal cancer
Authors: Shah Tilak , Kushnir Vladimir , Mutha Pritesh , Majhail Mankanchan , Patel Bhaumik , Schutzer Matthew , Mogahanaki Drew , Smallfield George , Patel Milan , Zfass Alvin
Published: October 2019

Background and study aims Liquid nitrogen spray cryotherapy (LNSC) can provide rapid dysphagia relief, and is postulated to stimulate a local antitumor immune response. The aim of this prospective pilot clinical trial was to evaluate the safety and efficacy of LNSC when administered prior to chemoradiotherapy.

Patients and methods Treatment-naïve adult patients with dysphagia at the time of biopsy-proven squamous carcinoma or adenocarcinoma of the esophagus were prospectively enrolled at two tertiary medical centers. Patients underwent a single session of LNSC. The primary outcome measure was change in dysphagia at 1 and 2 weeks post-cryotherapy. A secondary outcome measure was clinical complete response rate (CR) following chemoradiotherapy.

Results Twenty-five patients were screened, of whom 21 patients were eligible and enrolled. There were seven with metastatic and 14 with locally advanced cancer. The primary outcome of dysphagia improvement of ≥ 1 point occurred in 15/21 patients (71 %) at 1 week, and 10/20 patients (50 %) at 2 weeks. The median dysphagia score improved by 1 at 1 week (P = 0.0003), and 0.5 at 2 weeks (P = 0.02). Six of nine patients (67 %) with locally advanced cancer who completed chemoradiation did not have residual tumor cells on mucosal biopsy, and five of nine patients (56 %) had a clinical CR. There were no serious cryotherapy-related complications.

Conclusions LNSC provided safe and effective palliation for esophageal cancer patients who presented with dysphagia at index diagnosis. Its combination with chemoradiotherapy did not lead to any serious toxicity. Our study provides a scientific rationale for pursuing larger clinical trials addressing synergistic effects of combining LNSC with chemoradiation.
Muskuloskelettale Veränderungen rund um die Geburt
Authors: Köhler Barbara
Published: October 2019

Eine Schwangerschaft hat tiefgreifende Veränderungen von Muskeln, Gelenken und Nerven zur Folge. Es kann zu Beschwerden auf muskuloskelettaler Ebene kommen, die noch lange nach der Geburt bestehen bleiben. Physiotherapie in der Schwangerschaft und nach der Geburt leistet einen wichtigen Beitrag, um Schmerzen zu reduzieren sowie eine gesunde Haltung und physiologische Bewegungsabläufe wiederherzustellen.
Das Very early HELLP-Syndrom
Authors: Pauluschke-Fröhlich Jan
Published: October 2019

Das „Very early HELLP-Syndrom“ ist eine schwerwiegende Schwangerschaftskomplikation. Die fürs HELLP-Syndrom typische Trias aus Hämolyse, ansteigenden Leberwerten und einer Thrombozytopenie tritt zu einem Zeitpunkt auf, an dem das Kind außerhalb des Mutterleibes noch nicht lebensfähig ist. Mütterliche Risiken sprechen dafür, die Schwangerschaft zu beenden. Doch betroffene Paare wollen ihr Kind in ein Gestationsalter bringen, an dem es mit Maximalversorgung extrauterin lebensfähig wäre. Gefragt sind fachliches Augenmaß, hohe menschliche Kompetenz und eine interdisziplinäre Strategie, um tragfähige Entscheidungen treffen zu können.