bluuebunny/crossref_metadata_2025 huggingface dataset:
Home-based Palliative Intervention to Improve Quality of Life in Children with Cancer: A Randomized Controlled Trial
Authors: Andriastuti Murti , Halim Pricilia G , Tunjungsari Elnino , Widodo Dwi P
Published: December 2019

Background: In these last few years, an integrated approach between palliative care (PC) and chronic and/or life-threatening conditions care have been widely used. Home-based PC service is developed to meet the needs of the patients at home, but hasn’t been applied widely. This study is aimed to determine the benefit of integrated home-based PC in the quality of life (QOL) and symtomps intensity of Indonesian children with malignancies. Method: A randomized controlled trial to compare the quality of life between patients who were given PC (a 3-month home visit) and those who were not (intervention vs control group) was conducted, each group containing 30 children with cancer aged 2-18 years old who were consulted to palliative team. Participants were randomly assigned into each group. In the first and twelfth week of the intervention, all patients were assessed with the Pediatric Quality of Life Inventory (PedsQLTM) questionnaire cancer module 3.0 (report by proxy or self-report). Symptoms intensity (pain, anorexia, sleep disturbance) were scored by using Edmonton Symptoms Assessment Scale (ESAS). Mean score and each dimension score of both group were compared and analyzed using bivariate analysis. Results: A total 50 participants were included in analysis. Significant difference was found between two groups with average total score in control group 62.39 and intervention group 81.63 (p<0.001). In the intervention group QoL tends to improve, whereas in the control group, those did not get palliative intervention, quality of life tends to decrease as the disease progress. The most improved aspect in QoL is pain and nausea (p<0.001), followed by procedural anxiety (p=0.002), treatment anxiety (p=0.002), and worry (p=0.014). Palliative intervention was found to be able to reduce sleep disturbances (p=0.003) and anorexia (p<0.001) significantly. Conclusion: Home-based PC improved several aspects of the QOL and provide better symptoms management of children with malignancies. An early intervention concurrent with the underlying treatment is believed to be able to improve their quality of life. Trial Registration: This study has been retrospectively registered in ClinicalTrials.gov ID: NCT04067687 (August, 22nd 2019).
QTL and transcriptomic analyses for ammonia tolerance in the Pacific white shrimp (Litopenaeus vannamei)
Authors: Zeng Digang , Yang Chunling , Li Qiangyong , Zhu Weilin , Chen Xiuli , Peng Min , Chen Xiaohan , Lin Yong , Wang Huanling , Liu Hong , Liang Jingzhen , Liu Qingyun , Zhao Yongzhen
Published: December 2019

Background: Ammonia is one of the most common toxicological environment factors affecting shrimp health. Although ammonia tolerance in shrimp is closely related to successful industrial production, few genetic studies of this trait are available. Results: In this study, we constructed a high-density genetic map of the Pacific white shrimp (Litopenaeus vannamei) using specific length amplified fragment sequencing (SLAF-seq). The constructed genetic map contained 807,505 polymorphic markers spanning 44 linkage groups, with a total distance of 6,360.12 centimorgans (cM) and an average distance of 0.37 cM. Using this genetic map, we identified a quantitative trait locus (QTL) that explained 7.41–8.46% of the phenotypic variance in L. vannamei survival time under acute ammonia stress. We then sequenced the transcriptomes of the most ammonia-tolerant and the most ammonia-sensitive individuals from each of four genetically distinct L. vannamei families. We found that 7546 genes were differentially expressed between the ammonia-tolerant and ammonia-sensitive individuals. Using QTL analysis and the transcriptomes, we identified one candidate gene (annotated as an ATP synthase g subunit) associated with ammonia tolerance. Conclusions: In this study, we constructed a high-density genetic map of L. vannamei and identified a QTL for ammonia tolerance. By combining QTL and transcriptome analyses, we identified a candidate gene associated with ammonia tolerance. Our work provides the basis for future genetic studies focused on molecular marker-assisted selective breeding.
Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders
Authors: Zheng Jing , Liu Juan , Hong Beverly S , Li Yanbing
Published: December 2019

Background: The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear whether fat deposition in different areas of the body affects betatrophin expression. Here, we investigated the correlation between circulating betatrophin levels and body fat distribution in patients with different glucose tolerance. Methods: In 128 participants with impaired glucose tolerance (IGT; n = 64) or normal glucose tolerance (NGT; n = 64), we measured circulating betatrophin levels by enzyme-linked immunosorbent assay and body fat distribution (subcutaneous, visceral, and limb fat) using magnetic resonance imaging (MRI) and a body fat meter. Results: After controlling for age, sex, and BMI, betatrophin was correlated positively with visceral adipose tissue-to-subcutaneous adipose tissue ratio ( VAT/SAT ratio; r = 0.339, p = 0.009) and negatively with body fat ratio (BFR; r = -0.275, p = 0.035), left lower limb fat ratio (LLR; r = -0.330, p = 0.011), and right lower limb fat ratio (RLR; r = -0.288, p = 0.027) in the NGT group, with these correlations remaining after controlling for triglycerides. VAT/SAT ratio (standardized β = 0.419, p = 0.001) was independently associated with serum betatrophin levels; however, betatrophin was not associated with body fat distribution variables in the IGT group. Conclusions: Circulating betatrophin levels correlated positively with VAT/SAT ratio and negatively with lower limb fat, but not subcutaneous or upper limb fat, in individuals with normal glucose tolerance. Thus, betatrophin may be a poten­tial biomarker for body fat distribution in individuals without glucose disorders.
Rescue Therapy in Endovascualr Treatment for Acute Ischemic Stroke Due to Large Artery Atherosclerosis
Authors: Liu Mingli , Chen Minghui , Liu Yang , Lin Lin , Li Yongli , Feng Yan , Cai Jinquan , Li Ruiyan
Published: December 2019

Background and purpose Safety and predictors of rescue therapy in patients with acute ischemic stroke due to large artery atherosclerosis still remain unclear. This study aimed to test safety of rescue therapy and evaluate predictors of it after failed mechanical thrombectomy.Methods This retrospective study enrolled consecutively 245 patients with acute ischemic stroke treated by endovascular treatment from March 2016 to April 2019 in a single stroke center. We analyzed the clinical data and laboratory test for safety and predictors of rescue therapy. Binary logistic analysis was applied to confirm the independently relationship.Results There were totally 145 patients enrolled among 245 patients. Rescue therapy was independently associated with the excellent outcome [p=0.048, adjusted OR: 2.655, 95%CI: 1.008 – 6.989] and longer procedure time of endovascular treatment [p=0.004, adjusted OR: 3.722, 95%CI: 1.519-9.122], but there was no significance on complications and mortality. Prestrike incidence [p=0.004, adjusted OR:4.427, 95%CI:1.618-12.114], use of rt-PA [p=0.003, adjusted OR:4.792, 95%CI:1.688-13.602], tandem occlusion [p=0.001, adjusted OR:0.021, 95%CI:0.002-0.194], PLT [p=0.012, adjusted OR:3.234, 95%CI:1.289-8.113], P-LCR>42.3% [p=0.031, adjusted OR:0.132, 95%CI:0.021-0.827] were independent predictors of rescue therapy.Conclusions Rescue therapy for acute ischemic stroke due to large artery atherosclerosis costs more procedure time of endovascular treatment, but it can successfully recanalize the occlusive large artery and is independently related to the excellent clinical outcome without increasing ICH, sICH, reocclusion and others. Prestroke incidence, use of rt-PA, tandem occlusion, PLT and P-LCR may be independent predictors of rescue therapy in acute ischemic stroke due to large artery atherosclerosis.
Randomized, Placebo-controlled, Double-blind, Pilot Trial to Investigate Safety and Efficacy of Cerebrolysin in Patients with Aneurysmal Subarachnoid Hemorrhage
Authors: Woo Peter Yat-Ming , Lam Sandy , (Dr.) Joanna WK Ho , Ko Natalie MW , Li Ronald PT , Jian Leo , Chu Alberto CH , Kwan Marco CL , Chan Yung , Wong Alain KS , Wong Hoi-Tung , Chan Kwong-Yau , Kwok John CK
Published: December 2019

Background There are limited treatment options for aneurysmal subarachnoid hemorrhage (SAH)-induced delayed cerebral ischemia, a major determinant of mortality and morbidity. Cerebrolysin, a brain-specific pleiotropic neuroprotective agent, has been suggested to improve functional outcomes in ischemic stroke. We investigated the efficacy, safety and feasibility of Cerebrolysin for conferring such benefits in SAH patients. Methods This was a prospective, randomized, double-blind, placebo-controlled, single-center, parallel-group pilot study. 50 patients received either daily Cerebrolysin (30ml/day) or a placebo (saline) for 14 days (25 patients per study group). The primary endpoint was a favorable Extended Glasgow Outcome Score (GOSE) of 5 to 8 (moderate disability to good recovery) at six-months. Secondary endpoints included the occurrence of adverse effects, six-month mortality, the occurrence of cerebral vasospasm, delayed cerebral ischemia and infarction. Results No severe adverse effects or mortality attributable to Cerebrolysin were observed. No significant difference was detected in the proportion of patients with favorable six-month GOSE in either study group (odds ratio (OR): 0.53; 95% confidence interval (CI): 0.43-5.17). Secondary functional outcome measures for good six-month recovery indicated by a modified Rankin Scale of 0 to 2 (OR: 0.53; 95% CI 0.43-5.17) and a Barthel Index of 70 or more (OR: 0.52; 95% CI: 0.29-12.72) were also similar for both groups. There was a significantly lower risk of three- and six-month mortality for patients that received Cerebrolysin (OR: 0.46; 95% CI: 0.33-0.63). There were no deaths in the Cerebrolysin group, but the morality rate for the control group was 16% (4/25). The commonest cause of death was due to delayed cerebral ischemia. There were no differences in the overall incidence of delayed cerebral ischemia (p-value: 0.78), cerebral vasospasm (p-value: 0.16) and infarction (p-value: 0.77) between the two groups. Conclusions Use of Cerebrolysin in addition to standard-of-care management of aneurysmal SAH is safe, well tolerated and feasible. Results suggest a benefit in reducing three- and six-month mortality. Due to the exploratory nature of this study and its small sample size, these findings should be confirmed in a larger-scale clinical trial.
Integrating metabolic and evolutionary engineering for enhanced propionic acid production under cross stress: a multi-omics perspective
Authors: Liu Tingting , Zhao Qianru , Li Yang , Zhu Liying , Jiang Ling , Huang He
Published: December 2019

Background: Propionic acid (PA), a potential building block for C3-based bulk chemicals, is used as a food preservative and antifungal agent because of the antimicrobial properties of its calcium-, potassium-, and sodium salts, as well as in the manufacture of pharmaceuticals, perfumes, pesticides and fungicides. However, industrial development of PA is seriously inhibited by oxygen stress, acid stress and glucose-induced osmotic stress concentration on account of the characteristic of Propionibacterium acidipropionici. To alleviate inhibition and increase PA production, enhancement P. acidipropionici tolerance to cross stress may be an effective strategy. Results: In this study, we first performed a combination of metabolic engineering (deletion of ldh and poxB and overexpression of mmc) with evolutionary engineering (selection under oxygen stress, acid stress and osmotic stress) in P. acidipropionici. The results indicated the mutants received superior physiological activity, especially the mutant III exhibited steady 1.5-3.5 folds higher growth property and further 37.1% PA titer and 37.8% PA productivity increase than the wildtype. Moreover, omics analysis revealed the determinants such as Dps , GroES , dnaK , ADI and GAD referred to the acid adaptation of microbes were positively mobilized. ABC-type glycine betaine referred to the adaptability to osmotic stress was detected to be 2-4 folds up-regulated. More than 2-fold down-regulation of NADH oxidase and almost 3-fold up-regulation of SOD and POD were observed in three mutants. Moreover, an approximately 2.5-fold upregulation of mmc was also found.Conclusion: The multi-omics analysis revealed the multidirectional variation tendency of P. acidipropionici under cross stress and provided in-depth insights into the mechanism of tolerance and high production of PA, which layed the foundation for construction of microbial cell factories.
Different regulation of PARP1, PARP2, PARP3 and TRPM2 genes expression in acute myeloid leukemia cells
Authors: Gil-Kulik Paulina , Dudzińska Ewa , Radzikowska-Büchner Elżbieta , Wawer Joanna , Jojczuk Mariusz , Nogalski Adam , Wawer Genowefa Anna , Feldo Marcin , Kocki Wojciech , Cioch Maria , Bogucka-Kocka Anna , Rahnama Mansur , Kocki Janusz
Published: December 2019

Acute myeloid leukemia (AML) is a heterogenic lethal disorder characterized by the accumulation of abnormal myeloid progenitor cells in the bone marrow, which results in hematopoietic failure. Despite various efforts in detection and treatment, many patients with AML die of this cancer. That is why it is important to develop novel therapeutic options, employing strategic target genes involved in apoptosis and tumor progression. The aim of the study was to evaluate PARP1, PARP2, PARP3, and TRPM2 gene expression at the mRNA level in the cells of the hematopoietic system of the bone marrow in patients with acute myeloid leukemia, bone marrow collected from healthy patients, peripheral blood of healthy individuals, and hematopoietic stem cells from the peripheral blood after mobilization.Results: The results found that the bone marrow cells of patients with acute myeloid leukemia (AML) show over expression of PARP1 and PARP2 genes and decreased TRPM2 gene expression. In the hematopoietic stem cells derived from the normal marrow and peripheral blood after mobilization, the opposite situation was observed, i.e. TRPM2 gene showed increased expression while PARP1 and PARP2 gene expression was reduced. We observed the positive correlations between PARP1, PARP2, PARP3, and TRPM2 genes expression in the group of mature mononuclear cells derived from the peripheral blood and in the group of bone marrow-derived cells. In AML cells significant correlations were not observed between the expression of the examined genes.Conclusions: Our research suggests that in physiological conditions in the cells of the hematopoietic system there is mutual positive regulation of PARP1, PARP2, PARP3, and TRPM2 genes expression. PARP1, PARP2, and TRPM2 genes at mRNA level deregulate in acute myeloid leukemia cells.
Roles of neutrophil/lymphocyte ratio in prognosis and in differentiation of potential beneficiaries in HER2-positive breast cancer with trastuzumab therapy
Authors: Ding Nianhua , Huang Juan , Li Ningsha , Yuan Jiaqi , Wang Shouman , Xiao Zhi
Published: December 2019

Purpose: The relationship of neutrophil/lymphocyte ratio (NLR) with prognosis of HER2-positive breast cancer (BC) are not well studied. We aimed to assess the prognostic role of NLR in HER2-positive BC patients treated with or without trastuzumab.Methods: The clinical data of 843 HER2-positive BC patients from July 2013 to July 2018 were collected. The difference among variables was calculated by chi-square test. The associations between clinicopathological factors, NLR and disease-free survival (DFS) were analyzed by univariate and multivariate analyses.Results : Patients were divided into three groups. In group 1 containing 255 patients without trastuzumab treatment, pretreatment NLR showed no predictive value. Patients with trastuzumab treatment were divided into two groups on equal, according to pretreatment NLR values, low NLR (group 2) and high NLR (group 3). Patients in group 2 showed significantly higher 3-year DFS rate than patients in group 1 and group 3 (95.3% vs. 91.6% vs. 90.5%, respectively, P = 0.011); patients in the group 1 and group 3 had similar 3-year DFS outcome. Multivariate analysis showed high pretreatment NLR was significantly associated with shorter DFS (HR = 2.917, 95% CI=1.055-8.062, P = 0.039) in HER2-positive BC patients treated with trastuzumab. Conclusion : Among HER2-positive trastuzumab-treated BC patients, low pretreatment NLR value was associated with better DFS, and it might help to differentiate potential beneficiaries of trastuzumab treatment.
Simulation and Optimization Studies on the Ring Rolling Process Using Steel and Aluminum Alloys
Authors: Teja P. S. , Kumar M. D. , Krishna R. , Sreenivasan M.
Published: December 2019

The current research was carried out using ANSYS to optimize the process parameters for the ring rolling process. In order to optimize the ring rolling process, parameters such as speed, axial roller feed, and driving rollers have been assessed. As a process optimization approach, the optimum values of the parameters and their relationships need to be evaluated. The stress and strain levels were evaluated at various speeds and forces and the critical failure values were determined. The structural steel and aluminum alloys were chosen for this research because they are used as a roller and job part components in the solid wheels for locomotive applications, respectively. The study was conducted by varying the guide roller’s angular velocity from 40 to 45 rad/sec and varying the work piece’s angular velocity from 200 to 250 rad/sec. Additionally, the work part and roller’s fatigue strengths were determined based on the number of cycles before failure. To evaluate the stresses of plastic strain and von failures, the full stress analysis was also performed.
Keywords: roller, ANSYS, workpiece, plastic strain, von Misses stress, metal alloy.
Smart Territorial Development in Latvia: the Case of Zemgale Planning Region
Authors: Gemma Sergejs , Vītoliņa Zane
Published: December 2019

Since 2013, Latvia has defined the smart specialization strategy at national level. In 2020, the planned outcome is the increased capacity of innovations including the share of high and medium-high technology sectors in the export; the number of researchers employed in the private sector; an increase in manufacturing productivity and share of innovative enterprises. The regional policy has the task to establish and implement local smart specialization strategies in order to achieve the planned results in country. Evaluating Zemgale planning region, it develops according to monocentric development at average national level.
Piroliz Uygulanmış Çeltik Sapları ile Sulu Çözeltilerden Renk Giderimi
Authors: KAYKIOĞLU Gül , DALMIŞ İbrahim Savaş
Published: December 2019

Bu çalışmanın amacı, piroliz uygulanmış pirinç sapları ile (PPS) sulu çözeltilerden metilen mavisi (MB) giderim performansını değerlendirmektir. pH (4, 5.9 (doğal pH), 7, 9 ve 11), başlangıç boya konsantrasyonu (5, 10, 15 ve 20 mg / L) ve temas süresi (0, 1, 5, 15, 30, 60, 90 ve 120 dakika) gibi çeşitli deneysel parametrelerin etkisini değerlendirmek için sabit sıcaklıkta (20 oC) ve sabit adsorban dozunda (1 g/L) kesikli çalışmalar yapılmıştır. Ayrıca; farklı dozlarda (500, 1000, 1500, 2000 ve 2500 mg/L NaCl) tuz ilavesiyle iyonik şiddetin boya çözeltisinden renk giderim verimi üzerine etkisi değerlendirilmiştir. Boya çözeltisinin pH değerinin 4’ten 11’e yükseltilmesiyle PPS tarafından boya tutulumunun bir miktar azaldığı (qe değerleri için 8.5 mg/g’dan yaklaşık 8.2 mg/g’a) ve en iyi giderme veriminin doğal pH’ta elde edildiği gözlenmiştir. Bütün deneylerde boya tutulumu hızlı olmakta ve artan temas süresi ile birlikte adsorpsiyon artmaktadır. Metilen mavisi giderim verimi artan iyonik şiddet ile birlikte hafif artış göstermiştir. 2000 mg/L NaCl uygulamasında %91 giderme verimi elde edilirken, 2500 mg/L NaCl uygulamasında giderme verimi % 87’e düşmüştür. PPS ile MB adsorpsiyonunda R2 değerleri dikkate alındığında Freundlich modeline göre Langmuir modelinin daha uyumlu olduğu belirlenmiştir. MB boyarmaddesi için PPS adsorbanının maksimum adsorpsiyon kapasitesi 12.5 mg/g’dır. PPS için deneysel kinetik veriler yalancı birinci derece modele uyumludur (R2=0.9952).
HAYAT SİGORTALARINDA DOKTOR İNCELEMESİ
Authors: BAHAR SAYIN Hediye
Published: December 2019

Can sigortalarında, sigorta sözleşmesine konu rizikonun belirlenmesi açısından sigortalanacak kişinin sağlık durumuna ilişkin bilgilerin doğru şekilde tespit edilmesi önem taşır. Uygulamada söz konusu bilgiler soru formlarının yanıtlanması suretiyle elde edilir. Fakat sağlık alanındaki bilgilere hâkimiyet uzmanlık gerektirdiğinden, sigorta ettiren tarafından söz konusu bilgilerin sigortacıya doğru ve eksiksiz şekilde yansıtılması her zaman mümkün olmayabilir. Uygulamada, sigorta ettirenin soru formuna verdiği cevaplarda dikkat çekici bir durumun varlığı veya sigorta meblağının yüksek olması halinde sigortalanacak kişinin doktor incelemesinden geçirilmesinin taraflarca kararlaştırıldığı görülmektedir. Doktor incelemesine ilişkin yegâne hüküm TTK m.1492’dir. “Doktor incelemesi” kenar başlığı altında yer alan düzenlemeye göre “Sigorta ettiren ile sigortacı arasında, sigorta edilecek kişinin doktor incelemesinden geçmesi kararlaştırılmış olsa bile, sigortacı sigortalanacak kişiyi bu incelemeyi yaptırmaya zorlayamaz”. Hükmün gerekçesinde, düzenlemenin kişilik haklarını koruma altına aldığı vurgulanmaktadır.  Bu çalışmada, kişilik haklarının korunması bağlamında doktor incelemesine dair ilgili hükmün amaç ve kapsamının belirlenmesi, doktor incelemesine ilişkin düzenlemenin taraf yükümlülükleri açısından değerlendirilmesi ve sigortalanacak kişinin doktor incelemesini kabul etmemesinin hukuki sonuçlarının incelemesi hedeflenmiştir
Dioniso y la religión griega: entre Vernant y Detienne
Authors: Jaramillo Vega Lohengrin
Published: December 2019

El presente artículo aborda una de las problemáticas más inquietantes en el mundo de la religión griega, esta es la cuestión del culto a Dioniso, figura de la religión griega interpretada desde diversos puntos de vista, sus interpretaciones parecen vacilar y cambiar de acuerdo al contexto histórico-cultural desde donde se le intenta reconocer. Los matices y enfoques que se le dan a este dios de la antigüedad griega toman diversos rostros, tan dignos de ese esquivo dios-máscara de la alteridad y el arrebato. Este texto explora dos focos interpretativos pertenecientes a la escuela francesa. Comienza exponiendo los lineamientos que hace J.P Vernant entorno al carácter de la religión griega para así lograr entender qué papel juega el culto del dionisismo dentro del contexto de la antigua Atenas del siglo V a.c. A su vez Vernant quiere explicar qué tipo de alteridad asume Dioniso entre las demás divinidades limiti-formes portadoras de la máscara en los cultos antiguos. Luego contrastando los estudios de Vernant, Marcel Detienne por su parte elabora su línea interpretativa, y aun conservando algunos rasgos similares en la interpretación de Dioniso elaborada por Vernant, rastrea los pasos del dios por las sendas de la Hélade antigua estableciendo un paralelo de sus mitos con la instauración o fundación paulatina de su culto dentro de las diferentes regiones de la Antigua Grecia. Así logra colorear un dios liberador y al tiempo dueño de la negra manía, como una especie de fuerza salvaje que llega a civilizarse en los simposios atenienses, que tanto como civilización también provoca epidemia y locura.
Las tecnologías de la información y las comunicaciones en el proceso de ventas por catálogo como un apoyo para la gestión del vendedor: caso de estudio en Medellín, Antioquia
Authors: Gutierrez Arenas Andrea
Published: December 2019

El presente escrito se realizó bajo la metodología de estudio de caso múltiple, aplicado en el contexto de las ventas por catálogo. Se lograron evidenciar las implicaciones positivas y negativas que se han generado con el apoyo de tecnologías vigentes y han modificado el negocio tradicional de venta por catálogo utilizado por diferentes empresas en Colombia.A continuación, se expone cómo por medio de la tecnología, es decir, redes sociales, catálogos digitales y aplicaciones móviles, las herramientas digitales se convierten en un apoyo complementario para los vendedores, lo que permite interactuar con los clientes tradicionales y los clientes que tienen adaptado el concepto de tecnología en su proceso de compra. Ambas opciones son viables y cada una representa una oportunidad de negocio para las personas que se dedican a este canal.El estudio de caso se realizó con tres asesoras dedicadas a la venta de productos por catálogo, por medio de una entrevista semiestructurada utilizada como herramienta de recolección de la información. Dentro de esta entrevista se pudieron identificar los medios actuales de venta que utilizan las asesoras, así como considerar que la venta por este canal genera ingresos y un trabajo que les permite solventar el día a día de su actividad laboral y personal.Se evidenció que la venta por catálogo es un negocio en crecimiento y una de las mayores fuentes de ingresos de madres cabeza de familia en la ciudad de Medellín y en Colombia. Así mismo, cómo a través de este tipo de negocios se puede lograr obtener un beneficio económico sin la necesidad de manejar un horario o estar bajo la subordinación de alguien, razones por las cuales la gran mayoría de asesoras prefieren esta labor.
Book PR: do readers influence on the communication of publishing company?
Authors: Yezhyzhanska Tetiana , Krainikova Tetiana , Masimova Larysa
Published: December 2019

The impact of readers as target audiences of publishing houses in Ukraine on PR communication is not clearly understood. The goal of this research is to examine the role of readers in the communication process between publishing houses and customers. The readers become an important source of information about the events of the book publishing market and book novelties. The article shows the results of the poll of visitors of the largest book festivals in Ukraine – Book Arsenal Festival in Kyiv and Book Forum in Lviv for 2017–2019. These respondents (200 interviews per event) are not only the main consumers of book products publishing houses, but also they are the source of information about new books and activities of Ukrainian publishing houses themselves. According to the results of the poll, visitors of book fairs pay attention to the advice of their colleagues and friends, which are an important source of information about the events of the book publishing market and book novelties. Almost 50% of respondents create and distribute user-generated content about the events of the book publishing market. This activity is explained by the lack of information about the book market news of more than half of visitors. The results of the research confirm that readers are important publishing communications subjects, consumers are active advocates of the publisher’s brand, friends and colleagues actively create the content about the events of the book publishing market in Ukraine.
Uterine inflammatory conditions in cows: Types and etiopathogenesis
Authors: BRODZKI PIOTR
Published: December 2019

Uterine inflammatory conditions with associated fertility disorders are still a serious problem in dairy cow breeding, causing significant economic losses for breeders. Losses result from the costs of uterine infection treatment, fertility disorders, low pregnancy rates, reduced production of milk and the culling of the best cows in the herd due to infertility. According to literature data, uterine inflammatory conditions in cows are closely connected with the postpartum period, and reproductive system infections that occur at this time may persist beyond the postpartum period and cause reduced fertility in cows. Pathogenic microbiota are an underlying cause of the development and persistence of uterine inflammatory conditions. The microorganisms with an affinity for the endometrium that are most frequently isolated from the uterus of cows with metritis and endometritis are Trueperella pyogenes, Escherichia coli, Fusobacterium necrophorum and Prevotella melaninogenicus. No infectious agents may be detected in some inflammatory conditions that are related to the disregulation of intracellular prostaglandin synthesis in uterine endometrial cells. This condition, which is due to infection, may persist for differing periods of time after the elimination of pathogens and may impair the fertility of cows. It is currently believed that the persistence of inflammatory conditions of the uterus depends on the level of anti-infective immunological mechanisms, which not only eliminate pathogens and damaged tissue, but also protect the endometrium thanks to their regulatory properties. Not all defence mechanisms in the uterus have been discovered. Phagocytosis is the first and most important mechanism of defence against pathogens in the uterus of cows, involving specialized phagocytic cells, mainly neutrophils, monocytes and macrophages, which belong to the innate immune mechanisms, as well as migrate from blood at the inflammation site as a specific response. Immune system cells and endometrial epithelial cells, which until recently have been believed to be only a passive barrier to microorganisms, are actively involved in the recognition and initiation of the antiinfective immune response. According to many authors, disorders of the local mechanisms of uterine immunity are a basic cause of metritis and endometritis in dairy cows.
Parasitological monitoring of European bison in the Bieszczady Mountains
Authors: DEMIASZKIEWICZ ALEKSANDER W. , PYZIEL ANNA M. , FILIP-HUTSCH KATARZYNA , JANUSZCZAK MACIEJ , OLECH WANDA
Published: December 2019

The aim of our study was to determine the level of parasitic infections in European bison (Bison bonasus) in the Bieszczady Mountains on the basis of coprological methods: flotation, decantation and the Baermann technique. 429 faecal samples were collected from European bison in the following Forest Districts: Baligród, Komańcza, Lutowiska, Stuposiany, Lesko and Cisna. Examination of faeces revealed the presence of eggs of gastrointestinal nematodes from the Trichostrongylidae family, as well as Nematodirus sp., Aonchotheca sp. and Trichuris sp., larvae of lung nematodes Dictyocaulus viviparus, eggs of tapeworms Moniezia sp. and oocysts of 7 species of coccidia, belonging to the genus Eimeria (E. bovis, E. zuernii, E. pellita, E. bukidnonensis, E. subspherica, E. ellipsoidalis and E. brasiliensis). The population of European bison in the Bieszczady Mountains turned out to be the only free-living herd not infected with the liver fluke Fasciola hepatica. The level of parasitic infections, observed during present study, was low and did not indicate clinical signs of parasitic disease, thus it did not require deworming.
Mencegah Tindak Kekerasan pada Anak di Lembaga Pendidikan
Authors: Noer Khaerul Umam
Published: December 2019

The role of Pusat Pelayanan Terpadu Pem­ber­dayaan Perempuan dan Anak (P2TP2A)—translated in English: the Integrated Service Center for the Empowerment of Women and Children— in the context of development is very important in order to oversee the government's steps in minimizing and handling cases of violence against women and children which are getting higher intensity from year to year, especially in educational institutions in the form of peer violence and violence by teacher. This study seeks to describe the collaboration of P2TP2A and the Education Office of Depok City in preventing violence against children in educational insti­tutions. Observation and documentation studies are used as data collection techniques and qualitative descriptive analysis. This study produces findings including: 1) collab­oration of P2TP2A and the Education Agency in the prevention of violence against children in the educational environment carried out in the form of socialization “Stop violence on children” and the establishment of children's Forums; 2) involvement of P2TP2A in the recruitment of teachers and principals. The form of collaboration still needs to be improved, especially in the preparation of hidden curriculum programs for handling violence, budgeting violence prevention activities for children in the school environment, and strengthening the authority of prevention until the handling of violence against women and children. This collaboration is at least a starting point that Depok becomes one of the regions that is highly committed in realizing Child Friendly Cities so that children's rights in the context of education can be fulfilled and the number of violence against children can be minimized.
The Ukrainian Crisis and Russia: Theoretical and Technological Aspects of the Problem
Authors: Andreev Andrey
Published: December 2019

The article deals with the intermediate results of the use of a set of Russian political strategies and technologies in the Ukrainian direction of Foreign Policy since Ukraine gained independence. The research takes into account the peculiarities of the political development of Ukraine. The research objective was to identify the prerequisites, characteristics, and consequences of the Ukrainian political crisis at the turn of 2013–2014 and the resulting political regime and order. A systematic approach and comparative analysis made it possible to formulate a general assessment of the political situation in Ukraine following the so-called "the Revolution of Dignity". On the basis of formal-logical analysis, the author substantiated the need for a comprehensive audit of the amount of Russian technologies through the application of system analysis to certain political circumstances. The author substantiated the increasing role of political technologies of pro-active character in the situation of deep crisis of previously effective political institutions, mechanisms, and norms. The resonant nature of such technologies made it possible to link the latter with the political reflection on the place and role of Ukraine in the system of Russian Foreign Policy, as well as on the peculiarities of the Ukrainian political process and the nature of its political system. The author generalized the experience of Russian influence on the mentioned Ukrainian events and defined the general conditions that can allow Russia to affect a changeable political situation in the post-Soviet countries, taking into account the inconsistency of modern political trends. The scope of the results can be used in the spheres of foreign policy, public administration, and public policy.
Features of Political Pluralism in Ukraine: Formation of a New Party System Model
Authors: Kerimov Alexander , Verbitskaya Tatyana
Published: December 2019

The paper features the specifics of Ukrainian party system that formed after the collapse of the USSR. The research objective was to determine the vector of its development. The party system is considered as a political institute with the potential to stabilize the political system in the context of the evolution of Ukrainian statehood. The authors determined factors that influenced the formation of the Ukrainian party system: the transformation of the electoral system, the tightening of legislation on parties, and the change in the balance of power in the political arena. The research helped to identify the following signs of the Ukrainian party system: relative autonomy, closed character, stability, three-level structure (the state level, the regional level, and the local level). The comparative-historical method was used to highlight the stages of the evolution of the Ukrainian party system and its specifics. The functional method was used to determine the role of the party system in political processes. According to N. Luman’s structural-functional method, the main features of the Ukrainian party system can be described as a set of elements with the ability to maintain stability in the context of events that are taking place in the Ukraine political arena. The case-study method was used to study the features of the party system that formed in the context of the evolution of Ukrainian statehood, including such events as political crises and color revolution. The authors came to the conclusion that the Ukrainian party system has fully developed, but there are no prerequisites for its development within the framework of democratic pluralism. The study determined the prospects for democratic transit of the Ukrainian party system and its formation on the basis of political pluralism.
Zastosowanie różnych znaczników PET-CT w leczeniu i diagnostyce wznowy raka prostaty w oparciu o doniesienia zajazdowe z konferencji onkologicznej ASTRO 59 i przegląd literatury.
Authors: Burchardt Wojciech , Burchardt Ewa
Published: December 2019

Rak prostaty jest drugim co do częstości nowotworem u mężczyzn w Polsce i na świecie. Wskaźniki zachorowalności ciągle rosną, dlatego dane szacunkowe mówią, że w najbliższych latach będzie to najczęściej występujący nowotwór u mężczyzn w Polsce i prawdopodobnie wyprzedzi obecnie najczęściej występującego raka płuca.  Wznowa raka prostaty po leczeniu radykalnym może nawet dotyczyć ponad 50% u chorych w grupie wysokiego ryzyka i najczęściej manifestuje w postaci wzrostu stężenia antygenu sterczowego PSA (z ang. Prostate Specific Antigen). Badanie PET-CT z zastosowaniem najpopularniejszego znacznika   fluror-18-dezoksy-glukozy (18F-FDG) ma słabą czułość w badaniu raka gruczołowego prostaty, dlatego jest rzadko stosowany w tym rozpoznaniu.  Obecnie najczęściej stosowanym znacznikiem w diagnostyce rak prostaty w Polsce jest 11C – cholina, ale jej czułość przy stężeniu PSA poniżej 1 ng/ml nie jest dostatecznie wysoka. Pacjenci coraz częściej są poddawani badaniu PET- CT ze znakowanym galem 68 (68Ga) inhibitorem sterczowego antygenu błonowego (PSMA  z ang. prostate specific membrane antygen)  lub z 18-F- fluorocyclobutane-1-carboxilic acid fluciclovine (FACBC z ang. fluxiclovine), które dają możliwość zlokalizowania wznowy raka prostaty  w bardzo wczesnym stadium, gdy wartość PSA jest bardzo niska (poniżej 1 ng/ml). Ponadto czułość i specyficzność badania PET-CT z zastosowaniem znacznika 68Ga-PSMA jest bardzo wysoka mimo prowadzonego leczenia antyandrogenowego,  jest jednym z najbardziej obiecujących znaczników w badaniu PET.
Management of water distribution systems in PDA conditions using isolation valves: case studies of real networks
Authors: Fiorini Morosini A. , Caruso O. , Veltri P.
Published: December 2019

The current paper reports on a case study investigating water distribution system management in emergency conditions when it is necessary to seal off a zone with isolation valves to allow repair. In these conditions, the pressure-driven analysis (PDA) is considered to be the most efficient approach for the analysis of a water distribution network (WDN), as it takes into account whether the head in a node is adequate to ensure service. The topics of this paper are innovative because, until now, previous approaches were based on the analysis of the network behaviour in normal conditions. In emergency conditions, it is possible to measure the reliable functioning of the system by defining an objective function (OF) that helps to choose the optimal number of additional valves in order to obtain adequate system control. The OF takes into account the new network topology by excluding the zone where the broken pipe is located. The results show that the solution did not improve significantly when the number of valves reached a threshold. The procedure applied to other real case studies seems to confirm the efficiency of the methodology even if further examination of other cases in different conditions is necessary.
Effects of the Changing Aspect of Accounting on Accounting Education Conducted in Turkey: A Research on Independent Audit
Authors: Tarakcıoğlu Altınay Ayşenur , Elitaş Bilge Leyli , Marşap Beyhan
Published: December 2019

Accounting education
in Turkey are given in the undergraduate and graduate levels. At all levels of
accounting education, people gain different professional knowledge and skills.
Trainees participate in the accounting information production process at
different levels. Every work, every relationship, every work procedure, each
process and each procedure have to be constantly changed in the organizations,
so the members of the organization must be constantly changing. In today's
conditions, life is becoming an important issue in exchange with new
applications that institutions always create more value with innovation.
According to the system approach, the systems that take information, energy,
material from the environment, subject these inputs to the change process and
output them in different forms to the environment, i.e. to other systems, are
described as open systems. It is possible today for institutions to survive, to
be able to update themselves according to changes in their environment, and to
take advantage of the feedback process. Otherwise, institutions will show features
of closed systems. Closed systems that are resistant to change will be
entropic.
Association of CA 15-3 and CEA with Liver Metastases in Patients with Breast Cancer
Authors: Yazdani Akram , Akbari Hossein
Published: December 2019

Objective:

The liver is the second most common site of distant metastasis from breast
cancer that is usually associated with poor prognosis and low quality of life in breast cancer patients.
Therefore, the primary diagnosis of liver metastatic lesions in breast cancer patients is very
important. In this study, the ability of biochemical markers CA153, CEA, and ALP to be used for
prognostic liver metastasis in women with breast cancer was investigated.

Methods:

306 women with breast cancer recorded between 2008 and 2012 were included. Serum
concentrations of alkaline phosphatase (ALP), carcinogenicity antigen (CEA), cancer antigen
(CA-153), age, menopausal status, histologic type, tumor size and number of cancerous axillary
lymph nodes in two groups of breast cancer women with liver metastases and without it were
studied. To identify independent liver metastasis prognostic factors, logistic regression method
was applied.

Results:

The independent prognostic factors of liver metastases in women with breast cancer are
ALP, CEA, age, menopausal status, number of cancerous axillary lymph nodes and tumor size.
Sensitivity and specificity analysis showed that CEA with a cutoff value of 1.1 was the most accurate
predictive factor.

Conclusion:

The increase in the levels of CEA and ALP can be diagnostic markers for liver metastases
from breast cancer.
Drug Delivery Approaches for Doxorubicin in the Management of Cancers
Authors: Vyas Manish , Simbo Daniel A. , Mursalin Mohd. , Mishra Vijay , Bashary Roqia , Khatik Gopal L.
Published: December 2019

Aim:

We aimed to review the drug delivery approaches including a novel drug delivery
system of doxorubicin as an important anticancer drug.

Background:

Doxorubicin (DOX) is widely used against breast, uterine, ovarian, lung and cervical
cancer. It is listed among the essential medicines by WHO and is thus a very important drug
that can be used to fight against cancer. Despite its effectiveness, the use of the drug is limited due
to its dose-dependent toxicity. Several studies based on the DOX have suggested the need for
novel drug delivery formulations in the treatment of malignant and cancerous diseases due to its
cytotoxic nature.

Objectives:

This review focuses on the different formulations of DOX which is a useful drug in the
management of cancers, but associated with toxicity thus these approaches found applicability in
the reduction of its toxicity.

Methods:

We searched the scientific database using cancer, DOX, and different formulations as
the keywords. Here in only peer-reviewed research articles collected which were useful to our
current work.

Results:

This study is based on an examination of the recent advancements of its novel drug delivery
formulations. DOX hydrochloride is the first liposomal anticancer drug, administered via
the intravenous route, and also clinically approved for the treatment of lymphomas, leukemias,
and solid tumors. DOX is prepared into a liposomal formulation that contains polyethylene glycol
(PEG) layer around DOX containing liposome made by pegylation process. DOX also formulated
in nano-formulations which is also discussed herein led to reduced toxicity and increased efficacy.

Conclusion:

In the review, we described the significance of DOX in the form of different delivery
approaches in the management of cancers with a reduction in the associated toxicity.
Modeling Physico-Chemical Properties of Quinolone Derivatives Using GA-MLR as a Computational Study
Authors: Shirmohammadi Meysam , Mohammadinasab Esmat , Bayat Zakiyeh
Published: December 2019

Background:

In this study, we used a hierarchical approach to develop quantitative
structure-activity relationship (QSAR) models for modeling physico-chemical properties of quinolone
derivatives.

Objective:

The relationship between some of the molecular descriptors with physic-chemical
properties such as refractive index (n), polarizability (α) and HOMO-LUMO energy gap (ΔEH-L)
was represented.

Materials and Methods:

Quantum mechanical calculations using abinitio method at the #HF/6-
31++G** level were carried out to obtain the optimized geometry and then, the comprehensive set
of molecular descriptors was computed by using the Dragon software. Genetic algorithm using
multiple linear regression (GA-MLR) with backward method by SPSS software were utilized to
construct QSAR models.

Results:

The analytical powers of the established theoretical models were discussed using leaveone-
out (LOO) cross-validation technique. A multi-parametric equation containing maximum
three descriptors with suitable statistical qualities was obtained for predicting the studied properties.

Conclusion:

The QSPR analysis for the prediction of the refractive index, the polarizability and
the HOMO-LUMO energy gap of 40 quinolone derivatives using GA-MLR method was performed.
The achieved results showed that the best model for predicting the refractive index, the
polarizability and the HOMO-LUMO energy gap contains maximum three descriptors. MLR
analysis, using genetic algorithms as suitable descriptors selection method showed that the three
selected descriptors play a vital role in the prediction of physicochemical properties of quinolone
derivatives. It can be noted that the best descriptors in the final obtained models can be used to design
and screen new drugs.