bluuebunny/crossref_metadata_2025 huggingface dataset:
New reverse genetics and transfection methods to rescue arboviruses in mosquito cells
Authors: Atieh Thérèse , Nougairède Antoine , Klitting Raphaëlle , Aubry Fabien , Failloux Anna-Bella , de Lamballerie Xavier , Priet Stéphane
Published: October 2017

Reverse genetics is a critical tool to decrypt the biological properties of arboviruses. However, whilst reverse genetics methods have been usually applied to vertebrate cells, their use in insect cells remains uncommon due to the conjunction of laborious molecular biology techniques and of specific difficulties surrounding the transfection of such cells. To leverage reverse genetics studies in both vertebrate and mosquito cells, we designed an improved DNA transfection protocol for insect cells and then demonstrated that the simple and flexible ISA (Infectious Subgenomic Amplicons) reverse-genetics method can be efficiently applied to both mammalian and mosquito cells to generate in days recombinant infectious positive-stranded RNA viruses belonging to genera Flavivirus (Japanese encephalitis, Yellow fever, West Nile and Zika viruses) and Alphavirus (Chikungunya virus). This method represents an effective option to potentially overcome technological issues related to the study of arboviruses.
Language learning in the adult brain: disrupting the dorsolateral prefrontal cortex facilitates word-form learning
Authors: Smalle Eleonore H. M. , Panouilleres Muriel , Szmalec Arnaud , Möttönen Riikka
Published: October 2017

Adults do not learn languages as easily as children do. It has been hypothesized that the late-developing prefrontal cortex that supports executive functions competes with procedural learning mechanisms that are important for language learning. To address this hypothesis, we tested whether a temporary neural disruption of the left Dorsolateral Prefrontal Cortex (DLPFC) can improve implicit, procedural learning of word-forms in adults. Young adults were presented with repeating audio-visual sequences of syllables for immediate serial recall in a Hebb repetition learning task that simulates word-form learning. Inhibitory theta-burst Transcranial Magnetic Stimulation was applied to the left DLPFC or to the control site before the Hebb task. The DLPFC-disrupted group showed enhanced learning of the novel phonological sequences relative to the control group. Moreover, learning was negatively correlated with executive functions that rely on the DLPFC in the control group, but not in the DLPFC-disrupted group. The results support the hypothesis that a mature prefrontal cortex competes with implicit learning of word-forms. The findings provide new insight into the competition between brain mechanisms that contribute to language learning in the adult brain.
The morphology of antennal lobe projection neurons is controlled by a POU-domain transcription factor Bmacj6 in the silkmoth Bombyx mori
Authors: Namiki Shigehiro , Fujii Tsuguru , Shimada Toru , Kanzaki Ryohei
Published: October 2017

How to wire a neural circuit is crucial for the functioning of the nervous system. Here, we describe the neuroanatomy of the olfactory neurons in the spli mutant strain of silkmoth (Bombyx mori) to investigate the function of a transcription factor involved in neuronal wiring in the central olfactory circuit. The genomic structure of the gene Bmacj6, which encodes a class IV POU domain transcription factor, is disrupted in the spli mutant. We report the neuroanatomical abnormality in the morphology of the antennal lobe projection neurons (PNs) that process the sex pheromone. In addition to the mis-targeting of dendrites and axons, we found axonal bifurcation within the PNs. These results indicate that the morphology of neurons in the pheromone processing pathway is modified by Bmacj6.
Molecular phylogeny and divergence times of Astragalus section Hymenostegis: An analysis of a rapidly diversifying species group in Fabaceae
Authors: Bagheri Ali , Maassoumi Ali Asghar , Rahiminejad Mohammad Reza , Brassac Jonathan , Blattner Frank R.
Published: October 2017

The taxa of Astragalus section Hymenostegis are an important element of mountainous and steppe habitats in Southwest Asia. A phylogenetic hypothesis of sect. Hymenostegis has been obtained from nuclear ribosomal DNA internal transcribed spacer (ITS) and plastid ycf1 sequences of up to 303 individuals from 106 species, including all 89 taxa currently assigned to sect. Hymenostegis, 14 species of other Astragalus sections, and two species of Oxytropis and one Biserrula designated as outgroups. Bayesian phylogenetic inference and parsimony analyses reveal that three species from two other closely related sections group within sect. Hymenostegis, making the section paraphyletic. DNA sequence diversity is generally very low among Hymenostegis taxa, which is consistent with recent diversification of the section. We estimate that diversification in sect. Hymenostegis occurred in the middle to late Pleistocene, with many species arising only during the last one million years, when environmental conditions in the mountain regions of Southwest and Central Asia cycled repeatedly between dry and more humid conditions.
Selective molecular characterization of particulate matter from gasoline cars using internal extractive electrospray ionization mass spectrometry
Authors: Zhang Hua , Li Yi , Liu Kun , Zhu Liang , Chen Huanwen
Published: October 2017

A facile method based on iEESI-MS has been established to selectively profile the polar chemical composition of vehicular PM.
Enantioselective hydrogenation of N-heteroaromatics catalyzed by chiral diphosphine modified binaphthyl palladium nanoparticles
Authors: Xia Yun-Tao , Ma Jing , Wang Xiao-Dong , Yang Lei , Wu Lei
Published: October 2017

The first application of binaphthyl-stabilized palladium nanoparticles (Bin-PdNPs) with chiral modifiers in asymmetric hydrogenation of N-heteroaromatics is revealed.
Correction: catalytic enantioselective synthesis of α-nitroepoxides via aminolytic kinetic resolution
Authors: Meninno Sara , Napolitano Loris , Lattanzi Alessandra
Published: October 2017

Correction for ‘Catalytic enantioselective synthesis of α-nitroepoxides via aminolytic kinetic resolution’ by Sara Meninno et al., Catal. Sci. Technol., 2015, 5, 124–128.
An ionic liquid-based extraction system using diglycolamide functionalized macrocyclic platforms for the extraction and recovery of lanthanides
Authors: Wehbie M. , Arrachart G. , Ghannam L. , Karamé I. , Pellet-Rostaing S.
Published: October 2017

Macrocyclic-DGA platforms are engaged in an ionic liquid-based extraction system. The system exhibits selectivity for middle and heavy lanthanides.
A visible-light driven Bi2S3@ZIF-8 core–shell heterostructure and synergistic photocatalysis mechanism
Authors: Ding Yan-Hua , Zhang Xiao-Lei , Zhang Na , Zhang Jian-Yong , Zhang Rui , Liu Yu-Feng , Fang Yong-Zheng
Published: October 2017

A series of Bi2S3@ZIF-8 core–shell heterostructures has been synthesized using in situ self-assembly, which exhibit enhanced photocatalytic degradation of Rhodamine B under visible-light irradiation, reaching 25.3 times that observed for pristine Bi2S3 and 26.7 times that found for commercial Degussa P25.
Metal–organic frameworks for radionuclide sequestration from aqueous solution: a brief overview and outlook
Authors: Xiao Chengliang , Silver Mark A. , Wang Shuao
Published: October 2017

137Cs, 90Sr, 238U, 79Se, and 99Tc sequestrations from aqueous solution by metal–organic framework materials are summarized in this Frontier article.
Aquatic indirect photochemical transformations of natural peptidic thiols: impact of thiol properties, solution pH, solution salinity and metal ions
Authors: Chu Chiheng , Stamatelatos Dimitrios , McNeill Kristopher
Published: October 2017

Natural peptidic thiols are susceptible to sensitized photodegradation.
Application of nanotechnologies for removing pharmaceutically active compounds from water: development and future trends
Authors: Cai Zhengqing , Dwivedi Amarendra Dhar , Lee Wan-Ning , Zhao Xiao , Liu Wen , Sillanpää Mika , Zhao Dongye , Huang Ching-Hua , Fu Jie
Published: October 2017

The current review summarizes the recent advances in nanotechnology for PhACs removal and proposes possible further research directions.
Profiling polyphenol composition by HPLC-DAD-ESI/MSn and the antibacterial activity of infusion preparations obtained from four medicinal plants
Authors: Ziani Borhane E. C. , Barros Lillian , Boumehira Ali Z. , Bachari Khaldoun , Heleno Sandrina A. , Alves Maria Jose , Ferreira Isabel C. F. R.
Published: October 2017

Infusions ofT. pallescens,P. verticillataandL. guyonianumare a source of bioactive compounds.
Model system based proteomics to understand the host response during bacterial infections
Authors: Kamaladevi Arumugam , Marudhupandiyan Shanmugam , Balamurugan Krishnaswamy
Published: October 2017

An overall schematic representation of model animals and proteomics techniques used to understand the host response during bacterial infections.
Identification of novel N-acetylcysteine derivatives for the treatment of hepatocellular injury
Authors: Liu Shourong , Zhao Yanmei , He Ruoyu , Kong Limin , Xi Jianjun , Sun Jingjing , Shao Yidan , Pan Xuwang , Zhang Jiankang , Zhuang Rangxiao
Published: October 2017

N-acetylcysteine (NAC) derivatives were synthesized and screened for anti-hepatocellular injury activities against two different cell models in which the derivatives 6a and 6b displayed most potent with decreasing malondialdehyde (MDA) level.
Highly conductive and transparent single-walled carbon nanotube thin films from ethanol by floating catalyst chemical vapor deposition
Authors: Ding Er-Xiong , Jiang Hua , Zhang Qiang , Tian Ying , Laiho Patrik , Hussain Aqeel , Liao Yongping , Wei Nan , Kauppinen Esko I.
Published: October 2017

We report the high yield production of highly conductive and transparent single-walled carbon nanotube films from ethanol by the FCCVD method.
Manipulating the quantum interference effect and magnetotransport of ZnO nanowires through interfacial doping
Authors: Zhao Siwen , Wu Yiming , Zhang Kaixuan , Ding Huaiyi , Du Dongxue , Zhao Jiyin , Pan Nan , Wang Xiaoping
Published: October 2017

Our work demonstrates that the interfacial Δ-doping method can manipulate the quantum-interference effects and enhance the phase coherent transport properties of a nano-device.
A novel perovskite solar cell design using aligned TiO2 nano-bundles grown on a sputtered Ti layer and a benzothiadiazole-based, dopant-free hole-transporting material
Authors: Ameen Sadia , Nazim M. , Akhtar M. Shaheer , Nazeeruddin Mohammad Khaja , Shin Hyung-Shik
Published: October 2017

Using a benzothiadiazole-substituted derivative as a dopant free hole transporting layer in perovskite solar cells yields a 15% power conversion efficiency under one sun conditions.
The double-edged effects of annealing MgO underlayers on the efficient synthesis of single-wall carbon nanotube forests
Authors: Tsuji Takashi , Hata Kenji , Futaba Don N. , Sakurai Shunsuke
Published: October 2017

We demonstrated the profound relationship between the temperature of pre-annealing MgO underlayers and the synthesis of SWCNT forests.
SuFEx – a selectively triggered chemistry for fast, efficient and equimolar polymer–polymer coupling reactions
Authors: Brendel Johannes C. , Martin Liam , Zhang Junliang , Perrier Sébastien
Published: October 2017

The synergy between controlled radical polymerization methods and click chemistry enables the design of complex and well-defined materials.
Towards monochiral carbon nanotubes: a review of progress in the sorting of single-walled carbon nanotubes
Authors: Janas Dawid
Published: October 2017

This review provides an in-depth overview of the sorting methods of carbon nanotubes.
Caged circular siRNAs for photomodulation of gene expression in cells and mice
Authors: Zhang Liangliang , Liang Duanwei , Wang Yuan , Li Dong , Zhang Jinhao , Wu Li , Feng Mengke , Yi Fan , Xu Luzheng , Lei Liandi , Du Quan , Tang XinJing
Published: October 2017

Caged siRNAs with a circular structure were successfully used for photoregulation of target genes in both cells and mice.
Coordination chemistry with 1-methyl-5H-tetrazole: cocrystallization, laser-ignition, lead-free primary explosives – one ligand, three goals
Authors: Szimhardt Norbert , Wurzenberger Maximilian H. H. , Beringer Andreas , Daumann Lena J. , Stierstorfer Jörg
Published: October 2017

Numerous energetic coordination complexes (MnII, FeII, CoII, NiII, CuII, ZnII, and AgI) using 1-methyl-tetrazole as the ligand were synthesized and tuned by different counteranions (e.g. NO3−, ClO4−, picrate, and styphnate). They show great potential for mechanical or optical initiation systems.
3D hollow porous carbon microspheres derived from Mn-MOFs and their electrochemical behavior for sodium storage
Authors: Zou Guoqiang , Hou Hongshuai , Cao Xiaoyu , Ge Peng , Zhao Ganggang , Yin Dulin , Ji Xiaobo
Published: October 2017

In this work, 3D hollow porous carbon microspheres (3DHPCMs) are firstly prepared by the carbonization and post acid-treatment of 3D hollow microspherical Mn-MOFs (3DMn-MOFs).
Integration of polymers in the pore space of mesoporous nanocarriers for drug delivery
Authors: Zhang Jixi , Cai Kaiyong
Published: October 2017

The construction of carrier-polymer–drug hybrids in confined nanopore space is reviewed for advancing related drug delivery systems.
Excessive glucocorticoid-induced muscle MuRF1 overexpression is independent of Akt/FoXO1 pathway
Authors: Wang Xiao Juan , Xiao Jing Jing , Liu Lei , Jiao Hong Chao , Lin Hai
Published: October 2017

The ubiquitin-proteasome system (UPS)-dependent proteolysis plays a major role in the muscle catabolic action of glucocorticoids (GCs). Atrogin-1 and muscle-specific RING finger protein 1 (MuRF1), two E3 ubiquitin ligases, are uniquely expressed in muscle. It has been previously demonstrated that GC treatment induced MuRF1 and atrogin-1 overexpression. However, it is yet unclear whether the higher pharmacological dose of GCs induced muscle protein catabolism through MuRF1 and atrogin-1. In the present study, the role of atrogin-1 and MuRF1 in C2C12 cells protein metabolism during excessive dexamethasone (DEX) was studied. The involvement of Akt/forkhead box O1 (FoXO1) signaling pathway and the cross-talk between anabolic regulator mammalian target of rapamycin (mTOR) and catabolic regulator FoXO1 were investigated. High concentration of DEX increased MuRF1 protein level in a time-dependent fashion (P<0.05), while had no detectable effect on atrogin-1 protein (P>0.05). FoXO1/3a (Thr24/32) phosphorylation was enhanced (P<0.05), mTOR phosphorylation was suppressed (P<0.05), while Akt protein expression was not affected (P>0.05) by DEX. RU486 treatment inhibited the DEX-induced increase of FoXO1/3a phosphorylation (P<0.05) and MuRF1 protein; LY294002 (LY) did not restore the stimulative effect of DEX on the FoXO1/3a phosphorylation (P>0.05), but inhibited the activation of MuRF1 protein induced by DEX (P<0.05); rapamycin (RAPA) inhibited the stimulative effect of DEX on the FoXO1/3a phosphorylation and MuRF1 protein (P<0.05).
Structural and functional studies of SAV0551 from Staphylococcus aureus as a chaperone and glyoxalase III
Authors: Kim Hyo Jung , Lee Ki-Young , Kwon Ae-Ran , Lee Bong-Jin
Published: October 2017

The DJ-1/ThiJ/PfpI superfamily of proteins is highly conserved across all biological kingdoms showing divergent multifunctions, such as chaperone, catalase, protease, and kinase. The common theme of these functions is responding to and managing various cellular stresses. DJ-1/ThiJ/PfpI superfamily members are classified into three subfamilies according to their quaternary structure (DJ-1-, YhbO-, and Hsp-types). The Hsp-type subfamily includes Hsp31, a chaperone and glyoxalase III. SAV0551, an Hsp-type subfamily member from Staphylococcus aureus, is a hypothetical protein that is predicted as Hsp31. Thus, to reveal the function and reaction mechanism of SAV0551, the crystal structure of SAV0551 was determined. The overall folds in SAV0551 are similar to other members of the Hsp-type subfamily. We have shown that SAV0551 functions as a chaperone and that the surface structure is crucial for holding unfolded substrates. As many DJ-1/ThiJ/PfpI superfamily proteins have been characterized as glyoxalase III, our study also demonstrates SAV0551 as a glyoxalase III that is independent of any cofactors. The reaction mechanism was evaluated via a glyoxylate-bound structure that mimics the hemithioacetal reaction intermediate. We have confirmed that the components required for reaction are present in the structure, including a catalytic triad for a catalytic action, His78 as a base, and a water molecule for hydrolysis. Our functional studies based on the crystal structures of native and glyoxylate-bound SAV0551 will provide a better understanding of the reaction mechanism of a chaperone and glyoxalase III.
International Outcome Inventory for Hearing Aids: Data From a Large Swedish Quality Register Database
Authors: Arlinger Stig , Nordqvist Peter , Öberg Marie
Published: October 2017

Purpose

The purpose of this study was to analyze a database of completed International Outcome Inventory for Hearing Aids (IOI-HA) questionnaires obtained from over 100,000 clients fitted with new hearing aids in Sweden during the period of 2012–2016. Mean IOI-HA total scores were correlated with degree of hearing loss, unilateral versus bilateral fitting, first-time versus return clients, gender, and variation among dispensing clinics. The correlations with expectations, service quality, and technical functioning of the hearing aids were also analyzed.

Method

Questionnaires containing the 7 IOI-HA items as well as questions concerning some additional issues were mailed to clients 3–6 months after fitting of new hearing aids. The questionnaires were returned to and analyzed by an independent research institute.

Results

More than 100 dispensing clinics nationwide take part in this project. A response rate of 52.6% resulted in 106,631 data sets after excluding incomplete questionnaires. Forty-six percent of the responders were women, and 54% were men. The largest difference in mean score (0.66) was found for the IOI-HA item “use” between return clients and first-time users. Women reported significantly higher (better) scores for the item “impact on others” compared with men. The bilaterally fitted subgroup reported significantly higher scores for all 7 items compared with the unilaterally fitted subgroup. Experienced users produced higher scores on benefit and satisfaction items, whereas first-time users gave higher scores for residual problems. No correlation was found between mean IOI-HA total score and average hearing threshold level (pure-tone average [PTA]). Mean IOI-HA total scores were found to correlate significantly with perceived service quality of the dispensing center and with the technical functionality of the hearing aids.

Conclusions

When comparing mean IOI-HA total scores from different studies or between groups, differences with regard to hearing aid experience, gender, and unilateral versus bilateral fitting have to be considered. No correlation was found between mean IOI-HA total score and degree of hearing loss in terms of PTA. Thus, PTA is not a reliable predictor of benefit and satisfaction of hearing aid provision as represented by the IOI-HA items. Identification of a specific lower fence in PTA for hearing aid candidacy is therefore to be avoided. Large differences were found in mean IOI-HA total scores related to different dispensing centers.
Diagnosing and Screening in a Minority Language: A Validation Study
Authors: Zokoll Melanie A. , Wagener Kirsten C. , Kollmeier Birger
Published: October 2017

Purpose

The Turkish Digit Triplet Test for hearing self-screening purposes and the Turkish Matrix Test (TURMatrix) for follow-up hearing diagnostics offer an automated closed-set response format where patients respond by choosing from response alternatives. Their applicability for testing Turkish-speaking patients in their native language by German audiologists with different Turkish language skills was investigated.

Method

Tests were composed of spoken numbers (Turkish Digit Triplet Test) or sentences (TURMatrix). For 49 participants differing in hearing ability, speech reception thresholds (SRTs) in noise and quiet were obtained, for the TURMatrix with either the open- or closed-set response format, by audiologists with and without Turkish language skills, respectively.

Results

SRTs of both tests correlate closely with each other as well as with hearing ability, but not as closely as individual SRTs in quiet with hearing ability. SRTs in noise of listeners with normal hearing were about 0.7 dB lower for the closed-set than for the open-set response format.

Conclusions

The 2 tests yield comparable results and are applicable to professionals without suitable language skills. For the closed-set response format of the TURMatrix, literacy is crucial and supplemental (visual) cues improve performance. Speech audiometry in noise should assess suprathreshold processing deficits independently from language proficiency in the majority language.
Auditory Scene Analysis: An Attention Perspective
Authors: Sussman Elyse S.
Published: October 2017

Purpose

This review article provides a new perspective on the role of attention in auditory scene analysis.

Method

A framework for understanding how attention interacts with stimulus-driven processes to facilitate task goals is presented. Previously reported data obtained through behavioral and electrophysiological measures in adults with normal hearing are summarized to demonstrate attention effects on auditory perception—from passive processes that organize unattended input to attention effects that act at different levels of the system. Data will show that attention can sharpen stream organization toward behavioral goals, identify auditory events obscured by noise, and limit passive processing capacity.

Conclusions

A model of attention is provided that illustrates how the auditory system performs multilevel analyses that involve interactions between stimulus-driven input and top-down processes. Overall, these studies show that (a) stream segregation occurs automatically and sets the basis for auditory event formation; (b) attention interacts with automatic processing to facilitate task goals; and (c) information about unattended sounds is not lost when selecting one organization over another. Our results support a neural model that allows multiple sound organizations to be held in memory and accessed simultaneously through a balance of automatic and task-specific processes, allowing flexibility for navigating noisy environments with competing sound sources.

Presentation Video

http://cred.pubs.asha.org/article.aspx?articleid=2601618
Cortical and Sensory Causes of Individual Differences in Selective Attention Ability Among Listeners With Normal Hearing Thresholds
Authors: Shinn-Cunningham Barbara
Published: October 2017

Purpose

This review provides clinicians with an overview of recent findings relevant to understanding why listeners with normal hearing thresholds (NHTs) sometimes suffer from communication difficulties in noisy settings.

Method

The results from neuroscience and psychoacoustics are reviewed.

Results

In noisy settings, listeners focus their attention by engaging cortical brain networks to suppress unimportant sounds; they then can analyze and understand an important sound, such as speech, amidst competing sounds. Differences in the efficacy of top-down control of attention can affect communication abilities. In addition, subclinical deficits in sensory fidelity can disrupt the ability to perceptually segregate sound sources, interfering with selective attention, even in listeners with NHTs. Studies of variability in control of attention and in sensory coding fidelity may help to isolate and identify some of the causes of communication disorders in individuals presenting at the clinic with “normal hearing.”

Conclusions

How well an individual with NHTs can understand speech amidst competing sounds depends not only on the sound being audible but also on the integrity of cortical control networks and the fidelity of the representation of suprathreshold sound. Understanding the root cause of difficulties experienced by listeners with NHTs ultimately can lead to new, targeted interventions that address specific deficits affecting communication in noise.

Presentation Video

http://cred.pubs.asha.org/article.aspx?articleid=2601617
The SLP as Counselor for the Transgender Client
Authors: Adler Richard K.
Published: October 2017

This article describes the characteristics of the speech-language pathologist as counselor and outlines skills that the speech-language pathologist should possess to be an effective counselor with transgender clients. Three counseling approaches are described as they relate to working with transgender clients and the reader is given insight into how to use each approach; the author offers a new approach that is related directly to voice therapy with the transgender client.
Perceptions of Cluttering Among Communication Sciences and Disorders and Non Communication Sciences and Disorders Students
Authors: Blanchet Paul G. , Snyder Greg
Published: October 2017

Purpose

The aim of this study was to compare perceptions of cluttering of undergraduate Communication Sciences and Disorders majors with perceptions of non-majors.

Method

A total of 79 undergraduate students served as participants; 37 students were Communications Sciences and Disorders majors enrolled in an introductory-level course. The other 42 students were recruited from nutrition courses in the Department of Family and Consumer Sciences. All students were provided with a written definition of cluttering and also viewed a short segment of an educational video. Students then rated a person who clutters on a variety of speech skills and personality scales.

Results

Results revealed that the Communication Sciences and Disorders students rated a person who clutters as exhibiting a significantly more inappropriate speech rate than did the Family and Consumer Sciences majors. However, results revealed no significant group differences in ratings of any personality traits.

Conclusions

Findings do not support the presence of relatively positive perceptions of cluttering among Communication Sciences and Disorders majors, at least not prior to coursework or clinical training. Further research is needed to replicate these findings with larger sample sizes, and to assess attitudes of these students before and after coursework and/or clinical training in fluency disorders.
Star formation history of Canis Major OB1
Authors: Santos-Silva T. , Gregorio-Hetem J. , Montmerle T. , Fernandes B. , Stelzer B.
Published: October 2017

Aims. The Canis Major OB1 Association has an intriguing scenario of star formation, especially in the region called Canis Major R1 (CMa R1) traditionally assigned to a reflection nebula, but in reality an ionized region. This work is focussed on the young stellar population associated with CMa R1, for which our previous results from ROSAT, optical, and near-infrared data had revealed two stellar groups with different ages, suggesting a possible mixing of populations originated from distinct star formation episodes.

Methods. The X-ray data allow the detected sources to be characterized according to hardness ratios, light curves, and spectra. Estimates of mass and age were obtained from the 2MASS catalogue and used to define a complete subsample of stellar counterparts for statistical purposes.

Results. A catalogue of 387 XMM-Newton sources is provided, of which 78% are confirmed as members or probable members of the CMa R1 association. Flares (or similar events) were observed for 13 sources and the spectra of 21 bright sources could be fitted by a thermal plasma model. Mean values of fits parameters were used to estimate X-ray luminosities. We found a minimum value of log(LX [erg/s] ) = 29.43, indicating that our sample of low-mass stars (M⋆ ≤ 0.5 M⊙), which are faint X-ray emitters, is incomplete. Among the 250 objects selected as our complete subsample (defining our “best sample”), 171 are found to the east of the cloud, near Z CMa and dense molecular gas, of which 50% of them are young (<5 Myr) and 30% are older (>10 Myr). The opposite happens to the west, near GU CMa, in areas lacking molecular gas: among 79 objects, 30% are young and 50% are older. These findings confirm that a first episode of distributed star formation occurred in the whole studied region ~10 Myr ago and dispersed the molecular gas, while a second, localized episode (<5 Myr) took place in the regions where molecular gas is still present.
Alternsforschung – Die Biologie des Alterns
Authors: Bidder Julia
Published: October 2017

Die Alternsforschung steckt noch in den Kinderschuhen, hat aber nach gerade einmal zwei Jahrzehnten schon bahnbrechende Erfolge zu verzeichnen. So stießen Forscher vor einiger Zeit auf das erste Altersgen, das manche Fadenwürmer, Fruchtfliegen und Mäuse doppelt so lange leben lässt wie andere. Auch wir Menschen besitzen das Gen, das sich Foxo3a nennt.
Selbstwirksamkeit und posturale Kontrolle – YES, I CAN!
Authors: Huber Martin
Published: October 2017

Die Selbstwirksamkeit beeinfl usst, wie wir fühlen, denken, uns motivieren und verhalten. Dabei stehen Motorik und Psyche in einer Wechselwirkung zueinander. Überwiegt die motorische Komponente, will der Mensch handeln, kann es aber nicht. Überwiegt die psychische Komponente, könnte er zwar handeln, traut es sich aber nicht zu. Therapeuten können mit Selbstmanagementprogrammen helfen.
Indication Criteria for Total Knee Arthroplasty in Patients with Osteoarthritis – A Multi-perspective Consensus Study
Authors: Schmitt Jochen , Lange Toni , Günther Klaus-Peter , Kopkow Christian , Rataj Elisabeth , Apfelbacher Christian , Aringer Martin , Böhle Eckhardt , Bork Hartmut , Dreinhöfer Karsten , Friederich Niklaus , Frosch Karl-Heinz , Gravius Sascha , Gromnica-Ihle Erika , Heller Karl-Dieter , Kirschner Stephan , Kladny Bernd , Kohlhof Hendrik , Kremer Michael , Leuchten Nicolai , Lippmann Maike , Malzahn Jürgen , Meyer Heiko , Sabatowski Rainer , Scharf Hanns-Peter , Stoeve Johannes , Wagner Richard , Lützner Jörg
Published: October 2017

Background and Objectives Knee osteoarthritis (OA) is a significant public health burden. Rates of total knee arthroplasty (TKA) in OA vary substantially between geographical regions, most likely due to the lack of standardised indication criteria. We set out to define indication criteria for the German healthcare system for TKA in patients with knee OA, on the basis of best evidence and transparent multi-stakeholder consensus.

Methods We undertook a complex mixed methods study, including an iterative process of systematic appraisal of existing evidence, Delphi consensus methods and stakeholder conferences. We established a consensus panel representing key German national societies of healthcare providers (orthopaedic surgeons, rheumatologists, pain physicians, psychologists, physiotherapists), payers, and patient representatives. A priori defined consensus criteria were at least 70% agreement and less than 20% disagreement among the consensus panel. Agreement was sought for (1) core indication criteria defined as criteria that must be met to consider TKA in a normal patient with knee OA, (2) additional (not obligatory) indication criteria, (3) absolute contraindication criteria that generally prohibit TKA, and (4) risk factors that do not prohibit TKA, but usually do not lead to a recommendation for TKA.

Results The following 5 core indication criteria were agreed within the panel: 1. intermittent (several times per week) or constant knee pain for at least 3 – 6 months; 2. radiological confirmation of structural knee damage (osteoarthritis, osteonecrosis); 3. inadequate response to conservative treatment, including pharmacological and non-pharmacological treatment for at least 3 – 6 months; 4. adverse impact of knee disease on patientʼs quality of life for at least 3 – 6 months; 5. patient-reported suffering/impairment due to knee disease. Additional indication criteria, contraindication criteria, and risk factors for adverse outcome were also agreed by a large majority within the multi-perspective stakeholder panel.

Conclusion The defined indication criteria constitute a prerequisite for appropriate provision of TKA in patients with knee OA in Germany. In eligible patients, shared-decision making should eventually determine if TKA is performed or not. The next important steps are the implementation of the defined indication criteria, and the prospective investigation of predictors of success or failure of TKA in the context of routine care provision in Germany.
Mammakarzinom – komplementäre Praxis
Authors: Wey Stephan
Published: October 2017

Komplementäre onkologische Therapieverfahren ergänzen und bereichern die konventionellen Therapien der evidenzbasierten Schulmedizin (OP,
Strahlen-, Chemo- und Antihormontherapie u. a.). Dazu gehören Methoden, die in jedem Stadium einer Krebserkrankung sinnvoll in ein
koordiniertes Gesamtkonzept durch die behandelnden Chirurgen, Onkologen, Strahlentherapeuten und einem komplementären Arzt eingebettet sein
sollten sowie vom Patienten selbst angewendet werden können und die von einer erweiterten Diagnostik über allgemeine Basismaßnahmen über
Bewegung und Ernährung bis hin zur Anwendung von orthomolekularen Substanzen, Phytotherapie und sekundärer Pflanzenstoffe sowie weiterer
komplementärer Verfahren reichen.
Curcuma longa in der Onkologie
Authors: Kneer Vera Maria
Published: October 2017

Curcuma longa wird seit Jahrtausenden in der ayurvedischen und chinesischen Medizin bei zahlreichen Erkrankungen eingesetzt. Im Mittelpunkt
der Forschung steht überwiegend Curcumin, ein wesentlicher Bestandteil des Extrakts. In-vitro- und In-vivo-Studien haben vielfältige
Wirkmechanismen u. a. antioxidative und antiinflammatorische Wirkungen aufgezeigt. Bei zahlreichen Erkrankungen, v. a. mit entzündlicher
Genese sowie bei Tumorerkrankungen, hat sich der Einsatz von Curcumin als effektiv erwiesen. Curcumin beeinflusst alle Signalwege von der
Karzinogenese bis zur Metastasierung. Formulierungen mit verbesserter Bioverfügbarkeit sowie neue Applikationsformen versuchen
pharmakologische Schwächen des Pflanzenstoffes auszugleichen. Aktuell werden in Patientenstudien z. B. Kombinationen mit Chemotherapien und
Strahlentherapien erprobt. Daneben sind aber auch Kombinationen von Curcuma mit anderen Pflanzenstoffen zur Optimierung therapeutischer
Effekte in der integrativen Onkologie von großem Interesse.
Behandlungsfehlervorwürfe gegen Pädiater – eine Analyse von Gutachten des Medizinischen Dienstes der Krankenversicherung der Jahre 2000 bis 2014
Authors: Steinhauer Heiko , Holzschuh Joachim , Böhler Thomas
Published: October 2017

Hintergrund In Deutschland gibt es bislang nur wenige Informationen zu spezifisch gegen Pädiater gerichtete Vorwürfe medizinischer Behandlungsfehler (BHF). Der Medizinische Dienst der Krankenversicherung (MDK) begutachtet im Auftrag der gesetzlichen Krankenkassen regelmäßig BHF-Vorwürfe bei pädiatrischer Behandlung.

Methoden Analyse von 374 Gutachten, die zwischen dem 01.09.2000 und 31.08.2014 durch einen pädiatrischen Gutachter des MDK Baden-Württemberg erstellt wurden.

Ergebnisse 193 BHF-Vorwürfe gegen Pädiater wurden getrennt nach Versorgungssektoren ausgewertet (ambulant 35%, Normalstation 28%, Intensivstation 37%). Bei ambulanter Behandlung wurden häufiger Diagnosefehler vorgeworfen; die häufigsten begründenden Diagnosen waren Hüftdysplasie (n=6), Meningitis (n=5) und Pneumonie (n=4). Bei stationärer Behandlung wurden häufiger Therapiefehler vorgeworfen; häufigste begründende Diagnosen waren: Paravasate (n=7) sowie periventrikuläre Leukomalazie (n=7), Sepsis (n=6) und Hirnblutung (n=4) bei Neugeborenen auf Intensivstationen. 43% der ambulanten, 22% der normalstationären und 38% der intensivstationären BHF-Vorwürfe wurden gutachterlich bestätigt.

Diskussion und Schlussfolgerung Die Häufigkeiten von BHF-Vorwürfen scheinen in erster Linie von der Häufigkeit der Inanspruchnahme kinder- und jugendmedizinischer Leistungen abzuhängen. International bekannte diagnosespezifische Fallkonstellationen geben auch in Deutschland gehäuft Anlass zu einem BHF-Vorwurf. Die Analyse der Fälle nach Versorgungssektoren lässt nachvollziehbare Rückschlüsse für ein Risikomanagement zu.
Palliative Behandlung von Patienten mit fortgeschrittenem Pankreaskarzinom
Authors: Schad Friedemann
Published: October 2017

Integrative onkologische Therapiekonzepte sind eine Kombination aus konventionellen und komplementären Therapien. Die vorliegende
multizentrische Registerstudie untersuchte die Umsetzung von integrativen onkologischen Therapiekonzepten und der Assoziation mit dem
Überleben von Patienten im fortgeschrittenen Stadium IV bei Bauchspeicheldrüsenkrebs unter Gabe von Mistelextrakten – mit positiven
Effekten: Patienten mit kombinierter Chemo- und Misteltherapie zeigten einen statistisch signifikant besseren Überlebensvorteil als
Patienten mit alleiniger Chemotherapie; Patienten, die nur eine Misteltherapie erhielten, zeigten statistisch signifikant längere
Überlebensraten als jene, die weder Chemotherapie noch Misteltherapie erhielten.
Decomposing the permeability spectra of nanocrystalline finemet core
Authors: Varga Lajos K. , Kovac Jozef
Published: October 2017

In this paper we present a theoretical and experimental investigation on the magnetization contributions to permeability spectra of normal annealed Finemet core with round type hysteresis curve. Real and imaginary parts of the permeability were determined as a function of exciting magnetic field (HAC) between 40 Hz -110 MHz using an Agilent 4294A type Precision Impedance Analyzer. The amplitude of the exciting field was below and around the coercive field of the sample. The spectra were decomposed using the Levenberg–Marquardt algorithm running under Origin 9 software in four contributions: i) eddy current; ii) Debye relaxation of magnetization rotation, iii) Debye relaxation of damped domain wall motion and iv) resonant type DW motion. For small exciting amplitudes the first two components dominate. The last two contributions connected to the DW appear for relative large HAC only, around the coercive force. All the contributions will be discussed in detail accentuating the role of eddy current that is not negligible even for the smallest applied exciting field.
Critical exponent analysis of lightly germanium-doped La0.7Ca0.3Mn1-xGexO3 (x = 0.05 and x = 0.07)
Authors: Nanto Dwi , Kurniawan Budhy , Soegijono Bambang , Ghosh Nilotpal , Hwang Jong-Soon , Yu Seong-Cho
Published: October 2017

We have used a critical behavior study of La0.7Ca0.3MnO3 (LCMO) manganite perovskites whose Mn sites have been doped with Ge to explore magnetic interactions. Light Ge doping of 5 or 7 percent tended to produce LCMOs with second order magnetic transitions. The critical parameters of 5- and 7-percent Ge-doped LCMO were determined to be TC = 185 K, β = 0.331 ± 0.019, and γ = 1.15 ± 0.017; and TC = 153 K, β = 0.496 ± 0.011, and γ = 1.03 ± 0.046, respectively, via the modified Arrott plot method. Isothermal magnetization data collected near the Curie temperature (TC) was split into a universal function with two branches M(H,ε) = |ε|βf±(H/|ε|β+γ), where ε=(T–TC)/TC is the reduced temperature. f+ is used when T>TC, while f̲ is used when T<TC. Such results demonstrate the existence of ferromagnetic short-range order in lightly Ge-doped LCMOs. Notably, doping with Ge at high concentrations tends to generate long-range ferromagnetic order.
Microstructure and magnetism of Co2FeAl Heusler alloy prepared by arc and induction melting compared with planar flow casting
Authors: Titov A. , Jiraskova Y. , Zivotsky O. , Bursik J. , Janickovic D.
Published: October 2017

This paper is devoted to investigations of the structural and magnetic properties of the Co2FeAl Heusler alloy produced by three technologies. The alloys prepared by arc and induction melting have resulted in coarse-grained samples in contrast to the fine-grained ribbon-type sample prepared by planar flow casting. Scanning electron microscopy completed by energy dispersive X-ray spectroscopy, X-ray diffraction, Mössbauer spectroscopy, and magnetic methods sensitive to both bulk and surface were applied. The chemical composition was slightly different from the nominal only for the ribbon sample. From the viewpoint of magnetic properties, the bulk coercivity and remnant magnetization have followed the structure influenced by the technology used. Saturation magnetization was practically the same for samples prepared by arc and induction melting, whereas the magnetization of ribbon is slightly lower due to a higher Al content at the expense of iron and cobalt. The surface magnetic properties were markedly influenced by anisotropy, grain size, and surface roughness of the samples. The surface roughness and brittleness of the ribbon-type sample did not make domain structure observation possible. The other two samples could be well polished and their highly smooth surface has enabled domain structure visualization by both magneto-optical Kerr microscopy and magnetic force microscopy.
Comparison between measured and computed magnetic flux density distribution of simulated transformer core joints assembled from grain-oriented and non-oriented electrical steel
Authors: Shahrouzi Hamid , Moses Anthony J. , Anderson Philip I. , Li Guobao , Hu Zhuochao
Published: October 2017

The flux distribution in an overlapped linear joint constructed in the central region of an Epstein Square was studied experimentally and results compared with those obtained using a computational magnetic field solver. High permeability grain-oriented (GO) and low permeability non-oriented (NO) electrical steels were compared at a nominal core flux density of 1.60 T at 50 Hz. It was found that the experimental results only agreed well at flux densities at which the reluctance of different paths of the flux are similar. Also it was revealed that the flux becomes more uniform when the working point of the electrical steel is close to the knee point of the B-H curve of the steel.
Mitigating reentry radio blackout by using a traveling magnetic field
Authors: Zhou Hui , Li Xiaoping , Xie Kai , Liu Yanming , Yu Yuanyuan
Published: October 2017

A hypersonic flight or a reentry vehicle is surrounded by a plasma layer that prevents electromagnetic wave transmission, which results in radio blackout. The magnetic-window method is considered a promising means to mitigate reentry communication blackout. However, the real application of this method is limited because of the need for strong magnetic fields. To reduce the required magnetic field strength, a novel method that applies a traveling magnetic field (TMF) is proposed in this study. A mathematical model based on magneto-hydrodynamic theory is adopted to analyze the effect of TMF on plasma. The mitigating effects of the TMF on the blackout of typical frequency bands, including L-, S-, and C-bands, are demonstrated. Results indicate that a significant reduction of plasma density occurs in the magnetic-window region by applying a TMF, and the reduction ratio is positively correlated with the velocity of the TMF. The required traveling velocities for eliminating the blackout of the Global Positioning System (GPS) and the typical telemetry system are also discussed. Compared with the constant magnetic-window method, the TMF method needs lower magnetic field strength and is easier to realize in the engineering field.
Calculations of nuclear magnetic shielding constants based on the exact two-component relativistic method
Authors: Yoshizawa Terutaka , Hada Masahiko
Published: October 2017

From the matrix representation of the modified Dirac equation based on the restricted magnetically balanced gauge-including atomic orbital (RMB-GIAO) basis, previously one of the authors (Yoshizawa) and co-workers derived the two-component normalized elimination of the small component (2c-NESC) formulas for 2c relativistic calculations of nuclear magnetic resonance (NMR) shielding tensors. In the present study, at the Hartree-Fock (HF) level, we numerically confirm that for several molecules the RMB-GIAO-based 2c-NESC method provides gauge-origin independent NMR shielding values. Moreover, we investigate the accuracy of the 2c-NESC method by comparison with the 4c relativistic NMR calculations at the HF level. For noble gas dimers and Hg compounds, it is shown that the 2c-NESC method reproduces the 4c relativistic NMR shielding constants within errors of 0.12%–0.31% of the 4c relativistic values and yields chemical shifts sufficiently close to the 4c relativistic results. Also, we discuss the basis set convergence of NMR shielding constants calculated with the 2c-NESC and 4c relativistic methods.
Population density of eastern grey kangaroos (Macropus giganteus) in a periurban matrix at Coffs Harbour, New South Wales
Authors: Henderson Timothy , Rajaratnam Rajanathan , Vernes Karl
Published: October 2017

We surveyed eastern grey kangaroos at four locations at the Northern Beaches region of Coffs Harbour, New South Wales, to estimate densities in this growing peri-urban region. This region is considered a regional hotspot for human–kangaroo conflict, with numerous kangaroo-related incidents in recent years. Direct counts of kangaroos were undertaken every two months during 2016. Kangaroo densities varied between sites, ranging from 0.2 individuals ha–1 to 4.9 individuals ha–1. Because no estimates of population density exist for the Northern Beaches, our results assisted the development of a regional kangaroo management plan, and contribute to a broader understanding of eastern grey kangaroo densities in peri-urban areas.
Structural Variations in the Complete Series of Lanthanoid Complexes of a Calix[4]arene Trisamide
Authors: Nealon Gareth L. , McIldowie Matthew J. , Skelton Brian W. , Mocerino Mauro , Massi Massimiliano , Ogden Mark I.
Published: October 2017

Lanthanoid picrate (pic) complexes of 5,11,17,23-tetra-tert-butyl-25-hydroxy-26,27,28-tris(diethylcarbamoylmethoxy)calix[4]arene (LH) have been synthesised and structurally characterised, to complete this series for all lanthanoids (other than promethium). From cerium to lutetium, three structural types are observed: Type I, [Ln(L)(O,O′-pic)](pic), Ln=Ce–Dy; Type II, [Ln(L)(O-pic)](pic), Ln=Tb, Ho; Type III, [Ln(L)(HOEt)](pic)2, Ln=Er–Lu. With lanthanum, three different ten-coordinate complexes were characterised; [Ln(L)(O,O′-pic)(HOEt)](pic), [Ln(L)(O,O′-pic)(OH2)](pic), and [Ln(L)(O,O′-pic)(HOMe)](pic). The crystallisation of Type I and II observed for terbium shows that the stability of the different structures are sensitively poised at the transition points. Nevertheless, the structures show that the vacant space in the coordination sphere left by the trisamide L tends to reduce across the series as expected. It is occupied by a bidentate picrate anion and unidentate solvent molecule with lanthanum, a bidentate picrate anion for cerium to dysprosium (Type I), a unidentate picrate anion for terbium and holmium (Type II), and finally a unidentate solvent molecule from erbium to lutetium (Type III). The coordination number thus reduces from 10 to 8 across the series.
Syllable type development in toddlers acquiring Dutch
Authors: van den Berg Renate , Van Severen Lieve , Molemans Inge , Gillis Steven
Published: October 2017

Compiling syllable type inventories from children’s spontaneous speech is all but straightforward: so far studies vary considerably in their methodologies and consequently the selection of the speech samples differs. This paper shows that different methodologies for selecting a speech sample lead to substantial differences in syllable inventories. Two main sources for this variation are explored: differences in size and content of the speech samples. Both factors influence the results significantly and this questions the comparability of previous study results. An empirical procedure to investigate syllable type development is proposed to overcome such methodological problems, and this procedure is implemented to provide an initial empirically sound assessment of the acquisition of syllable types in Dutch speaking toddlers.