bluuebunny/crossref_metadata_2025 huggingface dataset:
Correction to: Shoulder Arthroplasty for Humeral Head Avascular Necrosis is Associated with Increased Postoperative Complications
Authors: Burrus M. Tyrrell , Cancienne Jourdan M. , Boatright Jeffrey D. , Yang Scott , Brockmeier Stephen F. , Werner Brian C.
Published: April 2018

Due to a metadata tagging error, the name of author M. Tyrell Burrus was indexed incorrectly. M. Tyrell is the given name and Burrus is the family name.
Estudo mecânico das propriedades dos fios de sutura usados em cirurgias ortopédicas
Authors: Gomide Leandro Cardoso , Campos Dagoberto de Oliveira , Araújo Cleudmar Amaral , Menegaz Gabriela Lima , Cardoso Rafael Silva , Saad Júnior Sérgio Crosara
Published: April 2018

Objetivo Avaliar as propriedades mecânicas dos fios de sutura normalmente usados nas cirurgias ortopédicas e caracterizar seu comportamento por meio de ensaios de tração para verificar qual deles apresenta maior resistência mecânica.

Método Os ensaios de tração dos diferentes tipos de fios de sutura foram feitos na máquina de ensaios mecânicos BME 10 kN, com célula de carga de capacidade máxima de 50 kgf. Foram ensaiadas sete amostras de cada tipo de fio de sutura, foram fixadas cada uma das extremidades da amostra na garra metálica própria para o ensaio de fios e manteve-se o comprimento inicial de 5 cm. Os ensaios foram feitos com uma velocidade de 20 mm/minuto e à temperatura ambiente, registraram-se os dados de força máxima e o deslocamento máximo na ruptura dos fios.

Resultados A força média de ruptura mais elevada foi observada na sutura FiberWire® 2 (Artrhex, Naples, FL, EUA) (240,17 N), seguida pela HiFi® 2 (Conmed, Utica, NY, EUA) (213,39 N) e Ethibond® 5 (Ethicon Inc., Somerville, NJ, EUA) (207,38 N). A menor força média de ruptura foi obtida para o fio Ethibond® 2 (Ethicon Inc., Somerville, NJ, EUA) (97,8 N).

Conclusão Os fios de sutura não absorvíveis de polimistura trançada, de surgimento mais recente, são superiores ao fio de sutura convencional de poliéster trançado. O FiberWire® 2 é o mais resistente dos fios avaliados no presente estudo.
Perﬁl dos pacientes diagnosticados com displasia do desenvolvimento do quadril
Authors: Barbosa Renan de Oliveira , Albernaz Elaine Pinto
Published: April 2018

Objetivo Descrever o perﬁl dos pacientes com displasia do desenvolvimento do quadril (DDQ), diagnosticados por meio de exame físico e ultrassonográﬁco, com a implantação do protocolo de atenção e rastreio de DDQ.

Métodos Estudo transversal que incluiu os portadores de DDQ nascidos de janeiro de 2014 a dezembro de 2016, na cidade de Pelotas, Sul do Brasil, que considerou os fatores etnia, sexo, peso ao nascer, posição fetal, lado de ocorrência, idade gestacional, idade materna e histórico familiar. Os dados de prontuário foram comparados com as características da população geral por meio do Sistema de Informação sobre Nascidos Vivos (Sinasc).

Resultados Foram identiﬁcados 33 portadores de DDQ, a maioria do sexo feminino, que mostrou uma probabilidade quatro vezes maior de apresentar a patologia (p < 0,001), e o lado mais acometido foi o esquerdo. Os recém-nascidos com apresentação pélvica tiveram uma probabilidade 15 vezes maior de ter DDQ (p < 0,001). Não foi encontrada associação estatisticamente signiﬁcativa com os seguintes fatores avaliados: peso ao nascer, idade gestacional, etnia e idade materna. Um total de 21 recém-nascidos necessitaram de tratamento imediato do quadril; a ecograﬁa demonstrou classiﬁcação IIb ou maior, pelo método de Graf, ou a radiograﬁa mostrou luxação nos portadores de DDQ com mais de seis meses de idade.

Conclusão O rastreio de DDQ é essencial em todos os recém-nascidos, e o exame físico, quando alterado, deve ser complementado com o ultrassonográﬁco para evitar o diagnóstico tardio da doença.
The Lancet Commission on Dementia Prevention, Intervention, and Care: a call for action
Authors: Orgeta V. , Mukadam N. , Sommerlad A. , Livingston G.
Published: April 2018

The purpose of this Editorial is to summarise the key recommendations of the Lancet Commission on Dementia Prevention, Intervention, and Care, reporting on the best available evidence to date on what we can do to prevent and intervene for dementia. We briefly describe the new life-course model of dementia prevention incorporating nine modifiable risk factors and their potential effect in reducing individuals’ risk of dementia. We also summarise the recommendations of the report about which pharmacological, psychological, and social interventions are effective, and improve outcomes for people with dementia and their families. Recent developments highlight that there is good potential for the prevention of dementia. Progress in evidence-based approaches indicate the potential for dementia care to be of high-quality and widely accessible. Acting upon this knowledge now will reduce the global burden of dementia and improve the lives of people living with dementia and their families.
Absence of Saharan dust influence on the strontium isotope ratios on modern trees from the Bahamas and Turks and Caicos Islands
Authors: Schulting Rick , Richards Mike , Pouncett John , Manco Bryan Naqqi , Freid Ethan , Ostapkowicz Joanna
Published: April 2018

We report on strontium (87Sr/86Sr) isotope results from 91 modern trees growing on the Bahamas and Turks and Caicos Islands. The average87Sr/86Sr ratio of 0.709169±0.000010 is consistent with the late Quaternary limestone of the islands and with the modern ocean value. The absence of any detectable influence of87Sr-enriched Saharan dust is notable, given the known contribution of this material to both past and recent soils of the Caribbean. Our results indicate that the impact of Saharan dust to the modern biosphere of the Bahamian archipelago is at least an order of magnitude less than modeled in currently available strontium isoscapes for the circum-Caribbean. We suggest that the bioavailability of Sr in Saharan dust may be considerably less than previously thought. Nevertheless, further work could usefully be carried out in the Bahamian archipelago on plants with different rooting depths, growing on different soil types and on limestone of different ages. Our results have particular relevance for the refinement of existing strontium isoscapes and the archaeological provenience of artifacts, animals, and people in the circum-Caribbean.
Increased frequency of torrential rainstorms during a regional late Holocene eastern Mediterranean drought
Authors: Ahlborn Marieke , Armon Moshe , Ben Dor Yoav , Neugebauer Ina , Schwab Markus J. , Tjallingii Rik , Shoqeir Jawad Hasan , Morin Efrat , Enzel Yehouda , Brauer Achim
Published: April 2018

Identifying climates favoring extreme weather phenomena is a primary aim of paleoclimate and paleohydrological research. Here, we present a well-dated, late Holocene Dead Sea sediment record of debris flows covering 3.3 to 1.9 cal ka BP. Twenty-three graded layers deposited in shallow waters near the western Dead Sea shore were identified by microfacies analysis. These layers represent distal subaquatic deposits of debris flows triggered by torrential rainstorms over the adjacent western Dead Sea escarpment. Modern debris flows on this escarpment are induced by rare rainstorms with intensities exceeding >30 mm h−1for at least one hour and originate primarily from the Active Red Sea Trough synoptic pattern. The observed late Holocene clustering of such debris flows during a regional drought indicates an increased influence of Active Red Sea Troughs resulting from a shift in synoptic atmospheric circulation patterns. This shift likely decreased the passages of eastern Mediterranean cyclones, leading to drier conditions, but favored rainstorms triggered by the Active Red Sea Trough. This is in accord with present-day meteorological data showing an increased frequency of torrential rainstorms in regions of drier climate. Hence, this study provides conclusive evidence for a shift in synoptic atmospheric circulation patterns during a late Holocene drought.
THE ORIGINS OF TRADESCANT’S ‘INDIA OCCIDENTALI’ WOODEN CLUBS:14C DATING, MATERIAL IDENTIFICATION AND STRONTIUM ISOTOPE STUDIES
Authors: Ostapkowicz Joanna , Roberts Alison , Thistlewood Jevon , Brock Fiona , Wiedenhoeft Alex C , Snoeck Christophe , Schulting Rick , Bray Warwick
Published: April 2018

This paper focuses on the material study (radiocarbon dating, wood identification and strontium isotope analyses) of four large ‘India occidentali’ clubs, part of the founding collections of the Ashmolean Museum, in Oxford, and originally part of John Tradescant’s ‘Ark’, in Lambeth (1656). During the seventeenth century, the term ‘India occidentali/occidentales’ referred not only to the ‘West Indies’ (its literal translation), but to the Americas as a whole; hence, the Ashmolean clubs and, indeed, thecforty examples of similarly large, decorated clubs known in international museum collections had no firm provenance and lacked even the most basic information. Previous attempts at attribution, based on stylistic comparisons with nineteenth- to twentieth-century Brazilian and Guyanese clubs, have proved inconclusive given the unique features of this club style, raising the intriguing possibility that these may be exceptionally rare examples of ‘Island Carib’ (Kalinago) material culture, particularly as images of such clubs appear in seventeenth-century ethnographic accounts from the Lesser Antilles. This paper provides new data for these poorly known objects from early collections, revealing not only the type of wood from which they were carved (Platymisciumsp. andBrosimumcfguianense) and their probable dates of manufacture (c AD1300–1640), but also their possible provenance (strontium results are consistent with a possible range from Trinidad south to French Guiana).
Medicine and Religion in Early Dominican Demonology
Authors: EVEN-EZRA AYELET
Published: April 2018

The article explores the theories of Roland of Cremonaop(†1259), the first Dominican master of theology in Paris and a practising physician, regarding demonic influence on body and soul. Roland uses contemporary neurological theories of voluntary motion and cognition to explain how precisely demons might move the bodily members of possessed subjects, induce seductive images and implant scientific knowledge. The complex interaction of fields of knowledge demonstrated in his unique theories sheds light on the intellectual climate of the early thirteenth century in general, and of the early Parisian Dominican school in particular.
Tracing the Evolution of Agglomeration Economies: Spain, 1860–1991
Authors: Beltrán Tapia Francisco J. , Díez-Minguela Alfonso , Martinez-Galarraga Julio
Published: April 2018

Using district population in Spain between 1860 and 1991, recorded approximately every decade, this article examines whether initial population affects subsequent population growth. While such a relationship between these two variables hardly existed during the second half of the nineteenth century, this link increased significantly between 1910 and 1970, although this trend was abruptly interrupted by the Civil War and the autarkic period that followed. The intensity of this relationship decreased in the 1970s, a process that continued during the 1980s. Our findings also stress that agglomeration economies were stronger in medium-size districts, especially from 1960 onwards.
Grounding responsibility in something (more) solid
Authors: Hirstein William , Sifferd Katrina
Published: April 2018

The cases that Doris chronicles of confabulation are similar to perceptual illusions in that, while they show the interstices of our perceptual or cognitive system, they fail to establish that our everyday perception or cognition is not for the most part correct. Doris's account in general lacks the resources to make synchronic assessments of responsibility, partially because it fails to make use of knowledge now available to us about what is happening in the brains of agents.
Acting without knowledge
Authors: Maibom Heidi Lene
Published: April 2018

I question whether psychological effects that an agent is unaware of can express her values and, if they can, whether this allows us to hold her responsible in the range of cases that we would like to.
Collaborating agents: Values, sociality, and moral responsibility
Authors: Doris John M.
Published: April 2018

I respond to the Behavioral and Brain Sciences commentaries on my book, Talking to Our Selves: Reflection, Ignorance, and Agency. I defend and amend both the skeptical challenge to morally responsible agency, that is, the book's impetus, and the anti-skeptical theory I develop to address that challenge. Regarding the skeptical challenge, I argue that it must be taken more seriously than some of my sanguine commentators assert, and consider some ways its impact might be blunted, such as by appeal to individual differences and the practical efficacy of human behavior. Regarding my positive theory, I defend the role of values in morally responsible agency against numerous criticisms, and consider various suggestions for elaborating my social, “collaborativist” account of morally responsible agency. In closing, I comment on the appropriate aspirations for theorizing about moral responsibility and agency.
Segmentation of design protocol using EEG
Authors: Nguyen Philon , Nguyen Thanh An , Zeng Yong
Published: April 2018

Design protocol data analysis methods form a well-known set of techniques used by design researchers to further understand the conceptual design process. Verbal protocols are a popular technique used to analyze design activities. However, verbal protocols are known to have some limitations. A recurring problem in design protocol analysis is to segment and code protocol data into logical and semantic units. This is usually a manual step and little work has been done on fully automated segmentation techniques. Physiological signals such as electroencephalograms (EEG) can provide assistance in solving this problem. Such problems are typical inverse problems that occur in the line of research. A thought process needs to be reconstructed from its output, an EEG signal. We propose an EEG-based method for design protocol coding and segmentation. We provide experimental validation of our methods and compare manual segmentation by domain experts to algorithmic segmentation using EEG. The best performing automated segmentation method (when manual segmentation is the baseline) is found to have an average deviation from manual segmentations of 2 s. Furthermore, EEG-based segmentation can identify cognitive structures that simple observation of design protocols cannot. EEG-based segmentation does not replace complex domain expert segmentation but rather complements it. Techniques such as verbal protocols are known to fail in some circumstances. EEG-based segmentation has the added feature that it is fully automated and can be readily integrated in engineering systems and subsystems. It is effectively a window into the mind.
Novel compact microstrip diplexer for GSM applications
Authors: Rezaei Abbas , Noori Leila
Published: April 2018

In this paper, a microstrip diplexer is designed based on a novel structure consisting of the meandrous and patch cells. It operates at 0.8 and 0.9 GHz for global system for mobile communications applications. The proposed diplexer is well miniaturized with an overall size of 0.01λg2. It has the narrowband channels making it appropriate for the modern long-range communication systems, which are widely accepted by the industry. The introduced diplexer has the other advantages of low insertion and return losses and the good isolation between channels better than −30 dB. Moreover, there is a good upper stopband rejection so that the first and second harmonics are suppressed with a maximum level of −30 dB. The designing method is based on finding the effective parameters to control the resonance frequency, miniaturization and harmonic attenuation simultaneously. To validate the designing method and simulation results, the proposed diplexer is fabricated and measured. There is a good agreement between the simulated and measured results.
A highly selective UWB bandpass filter using stepped impedance stubs
Authors: Jung Minjae , Min Byung-Wook
Published: April 2018

We present a new ultra-wideband (UWB) band-pass filter (BPF) configuration with a stepped impedance short-circuited stub (SISS)-loaded triple-mode resonator (TMR) and stepped impedance radial stub (SIRS). The novel SISS-loaded TMR and SIRS improve the roll-off ratio at both ends. Even though this UWB BPF is based on a single resonator, the measured results show excellent in-band performance with a small insertion loss less than 0.6 dB and return loss greater than −16 dB. The proposed UWB BPF has sharp roll-off ratio of 96 and 43 dB/GHz, respectively, at the lower and upper edges of the pass-band, and a wide stop-band from 10.8 to 15.6 GHz with the rejection greater than 20 dB.
Analysis of multipath and DOA detection using a fully polarimetric automotive radar
Authors: Visentin Tristan , Hasch Jürgen , Zwick Thomas
Published: April 2018

Multipath propagation occurs in many situations of radar measurements in complex environments. The unwanted effects range from interference over the radar channels, which causes amplitude fading and a corrupted direction of arrival (DOA) estimation, to the detection of ghost targets in an angle of arrival of the multipath direction. Due to the different number of reflections, polarimetric radars are capable to separate certain multipaths from direct paths if the target is known in advance. Furthermore, it is possible to separate objects with different polarimetric features in DOA that are located in the same radial distance to the radar. In this paper, a new approach to DOA detection based on the coherent Pauli decomposition is presented. With this approach, important multipath and DOA effects are analyzed and measurement results at 77 GHz on canonical objects in an anechoic chamber are presented. The results prove the feasibility of the approach and demonstrate the occurring effects.
A metamaterial absorber based high gain directional dipole antenna
Authors: Pushpakaran Sarin Valiyaveettil , Purushothama Jayakrishnan M. , Mani Manoj , Chandroth Aanandan , Pezholil Mohanan , Kesavath Vasudevan
Published: April 2018

A novel idea for generating directional electromagnetic beam using a metamaterial absorber for enhancing radiation from a microwave antenna in the S-band is presented herewith. The metamaterial structure constitutes the well-known stacked dogbone doublet working in the absorption mode. The reflection property of the dogbone metamaterial absorber, for the non-propagating reactive near-field, is utilized for achieving highly enhanced and directional radiation characteristics. The metamaterial absorber converts the high-spatial reactive spectrum in the near-field into propagating low-spatial spectrum resulting in enhanced radiation efficiency and gain. The gain of a printed standard half-wave dipole is enhanced to 10 dBi from 2.3 dBi with highly directional radiation characteristics at resonance.
Epitaxial facet junctions on TiO2 single crystals for efficient photocatalytic water splitting
Authors: Zhang Ai-Yong , Wang Wei-Yi , Chen Jie-Jie , Liu Chang , Li Qun-Xiang , Zhang Xing , Li Wen-Wei , Si Yang , Yu Han-Qing
Published: April 2018

Metal oxide semiconductors with surface homojunctions characteristic of continuous band bending and well-defined epitaxial interfaces show amazing potential for photocatalytic applications.
Graphene–silver hybrid devices for sensitive photodetection in the ultraviolet
Authors: Paria Debadrita , Jeong Hyeon-Ho , Vadakkumbatt Vaisakh , Deshpande Preeti , Fischer Peer , Ghosh Arindam , Ghosh Ambarish
Published: April 2018

The weak light–matter interaction in graphene can be enhanced with a number of strategies, among which sensitization with plasmonic nanostructures is particularly attractive.
A novel supramolecular polymer network based on a catenane-type crosslinker
Authors: Wang Wenbo , Xing Hao
Published: April 2018

A novel supramolecular mechanically interlocked crosslinker was designed and used to prepare a supramolecular polymer network.
Synthesis of bithiazole-based semiconducting polymers via Cu-catalysed aerobic oxidative coupling
Authors: Faradhiyani Alanna , Zhang Qiao , Maruyama Keisuke , Kuwabara Junpei , Yasuda Takeshi , Kanbara Takaki
Published: April 2018

A combination of direct arylation and aerobic oxidative coupling reactions enables a straightforward synthesis of semiconducting materials.
Fabrication of hydroxyapatite coatings on AZ31 Mg alloy by micro-arc oxidation coupled with sol–gel treatment
Authors: Tang Hui , Tao Wei , Wang Chao , Yu Huilong
Published: April 2018

Magnesium (Mg) alloys, can potentially be used as biodegradable orthopedic implants because of their biodegradability and good mechanical properties.
Study on the transcriptional regulatory mechanism of the MyoD1 gene in Guanling bovine
Authors: Zhou Di , Xu Houqiang , Chen Wei , Wang Yuanyuan , Zhang Ming , Yang Tao
Published: April 2018

The MyoD1 gene plays a key role in regulating the myoblast differentiation process in the early stage of skeletal muscle development.
Preparation of a novel polyacrylic acid and chitosan interpenetrating network hydrogel for removal of U(vi) from aqueous solutions
Authors: He Jiarui , Sun Fuliang , Han Fuhao , Gu Junjie , Ou Minrui , Xu Wenkai , Xu Xiaoping
Published: April 2018

A clean and simple method has been developed for preparation of interpenetrating polymer networks using polyacrylic acid (PAA) and chitosan (CS) for extraction of uranium from polluted water.
A novel crosslinking agent of polymethyl(ketoxime)siloxane for room temperature vulcanized silicone rubbers: synthesis, properties and thermal stability
Authors: Zhan Xibing , Cai Xiqing , Zhang Junying
Published: April 2018

A novel cross-linker polymethyl(ketoxime)siloxane was synthesized and then was cured with hydroxyl-terminated polydimethylsiloxane matrix to fabricate a series of novel RTV silicone rubber. Their properties was comparatively investigated.
Iriomoteolides: novel chemical tools to study actin dynamics
Authors: Unzue A. , Cribiú R. , Hoffman M. M. , Knehans T. , Lafleur K. , Caflisch A. , Nevado C.
Published: April 2018

This work broadcasts iriomoteolides as a novel and easily tunable tool for the study of actin polymerization and actin dynamics.
Soft modes and strain redistribution in continuous models of amorphous plasticity: the Eshelby paradigm, and beyond?
Authors: Cao Xiangyu , Nicolas Alexandre , Trimcev Denny , Rosso Alberto
Published: April 2018

In amorphous solids, the strain redistribution halo around local plastic events can have a standard Eshelby shape (a), or concentrate along the shearing axes (b).
Self-assembly of collagen-based biomaterials: preparation, characterizations and biomedical applications
Authors: Zhu Shichen , Yuan Qijuan , Yin Tao , You Juan , Gu Zhipeng , Xiong Shanbai , Hu Yang
Published: April 2018

By combining regulatory parameters with characterization methods, researchers can selectively fabricate collagenous biomaterials with various functional responses for biomedical applications.
Investigations on the elasticity of functional gold nanoparticles using single-molecule force spectroscopy
Authors: Sun Li , Riedel René , Stanciu Stefan G. , Yang Fang , Hampp Norbert , Xu Li , Wu Aiguo
Published: April 2018

In this focused review we turn our attention towards several approaches for detecting the elasticity of NPs, systematically summarizing the divergent elasticity values of distinct gold nanoparticles (AuNPs) with different surfaces.
Simultaneous quantitative analysis of retagliptin and its main active metabolite in human multiple matrices by liquid chromatography tandem mass spectrometry
Authors: Meng Xiangjun , Cai Lanlan , Ren Tianming , Sun Dong , Gu Jingkai
Published: April 2018

Simultaneous quantification of retagliptin and retagliptin acid by LC-MS/MS.
Disposable graphene sensor with an internal reference electrode for stripping analysis of heavy metals
Authors: Liu Shiwei , Wu Tongshun , Li Fenghua , Zhang Qixian , Dong Xiandui , Niu Li
Published: April 2018

An all-graphene-based disposable sensor with a ‘built in’ internal reference was applied for the stripping analysis of heavy metals.
A supramolecular assembly enables discrimination between metalloproteins and non-metalloproteins
Authors: Pettiwala Aafrin M. , Singh Prabhat K.
Published: April 2018

A supramolecular assembly yields turn-on fluorescence response for non-metalloproteins and turn-off response for metalloproteins.
Halogen type as a selectivity switch in catalysed alkane oxyhalogenation
Authors: Zichittella Guido , Puértolas Begoña , Paunović Vladimir , Block Theresa , Pöttgen Rainer , Pérez-Ramírez Javier
Published: April 2018

The type of halogen enables a powerful selectivity control ranging from olefins in oxychlorination to alkyl bromides in oxybromination over europium oxyhalide catalysts.
Aero-gel assisted synthesis of anatase TiO2 nanoparticles for humidity sensing application
Authors: Poonia Ekta , Mishra Prashant Kumar , Kiran Vijay , Sangwan Jasbir , Kumar Rakesh , Rai Pramod Kumar , Tomer Vijay K.
Published: April 2018

The aero-gel based one-pot synthesis of anatase phase TiO2 nanoparticles having a high surface area of 125 m2 g−1 has been reported in this work.
New tetrahydroisoquinoline-based P-glycoprotein modulators: decoration of the biphenyl core gives selective ligands
Authors: Contino Marialessandra , Guglielmo Stefano , Perrone Maria Grazia , Giampietro Roberta , Rolando Barbara , Carrieri Antonio , Zaccaria Daniele , Chegaev Konstantin , Borio Vanessa , Riganti Chiara , Zabielska-Koczywąs Katarzyna , Colabufo Nicola A. , Fruttero Roberta
Published: April 2018

Among the new selective P-gp modulators reported, compound 12a almost completely restores doxorubicin cytotoxicity in resistant cancer cells.
Synthesis of SnO2nanofibers and nanobelts electron transporting layer for efficient perovskite solar cells
Authors: Mali Sawanta S. , Patil Jyoti V. , Kim Hyungjin , Hong Chang Kook
Published: April 2018

The implementation of positive alternative electron transporting layers (ETLs) with excellent electronic properties is a most promising method to up-scale low-cost highly efficient perovskite solar cell (PSC) technology.
Preparation of irrefrangible polyacrylamide hybrid hydrogels using water-dispersible cyclotetrasiloxane or polyhedral oligomeric silsesquioxane containing polymerizable groups as cross-linkers
Authors: Yanagie Makoto , Kaneko Yoshiro
Published: April 2018

Irrefrangible polyacrylamide hybrid hydrogels were prepared using polymerizable siloxane oligomers as cross-linkers (CyTS-MNaandPOSS-MNa, respectively).
Thiacalix[4]arene-supported tetradecanuclear cobalt nanocage cluster as precursor to synthesize CoO/Co9S8@CN composite for supercapacitor application
Authors: Shi Cheng , Chen Mengwei , Han Xu , Bi Yanfeng , Huang Liangliang , Zhou Kun , Zheng Zhiping
Published: April 2018

A new high nuclearity N,S-co-rich Co14 cage cluster was used as a precursor to synthesize CoO/Co9S8@CN composites for applications in supercapacitors.
FeP nanoparticles: a new material for microwave absorption
Authors: Green Michael , Tian Lihong , Xiang Peng , Murowchick James , Tan Xinyu , Chen Xiaobo
Published: April 2018

FeP nanoparticles, fabricated through a facile thermal phosphorization process, have displayed impressive microwave absorption performance with tunable frequency and large reflection loss (RL) values.
Study on the formation and properties of red blood cell-like Fe3O4/TbLa3(Bim)12/PLGA composite particles
Authors: Li Ping , Qi Bing , Li Kun , Xu Junwei , Liu Meili , Gu Xuenan , Niu Xufeng , Fan Yubo
Published: April 2018

Fe3O4/TbLa3(Bim)12/PLGA composite particles as drug delivery system, generated by electrospraying, showed bioinspired red blood cell-like structure and magnetic-fluorescent multifunctions.
Transcriptome analysis reveals GA induced apoptosis in HCT116 human colon cancer cells through calcium and p53 signal pathways
Authors: Yang Chen , Xie Xiaoyu , Tang Hu , Dong Xuyan , Zhang Xiaodong , Huang Fenghong
Published: April 2018

Gallic acid (GA) is a polyphenol widely found in plants that induced apoptosis in human colon cancer cells through calcium and p53 signal pathways.
Local delivery of a novel PTHrPviamesoporous bioactive glass scaffolds to improve bone regeneration in a rat posterolateral spinal fusion model
Authors: Liang Bo , Huang Jinghuan , Xu Jianguang , Li Xiaolin , Li Jingfeng
Published: April 2018

With the development of tissue engineering, bone defects, such as fractured long bones or cavitary lesions, may be efficiently repaired and reconstructed using bone substitutes.
Very fast hot carrier diffusion in unconstrained MoS2on a glass substrate: discovered by picosecond ET-Raman
Authors: Yuan Pengyu , Tan Hong , Wang Ridong , Wang Tianyu , Wang Xinwei
Published: April 2018

Very high nonmonotonic thickness-dependent hot carrier diffusivity of MoS2in a normal-κdielectric screening environment was discovered by ET-Raman technique.
Divergent synthesis of dual 1,4-dihydropyridines with different substituted patterns from enaminones and aldehydes through domino reactions
Authors: Liu Fu-Jun , Sun Tian-Tian , Yang Yun-Gang , Huang Chao , Chen Xue-Bing
Published: April 2018

A concise and efficient protocol for the regioselective synthesis of dual 1,4-dihydropyridines with several substituted patterns has been developed from a cascade cyclization of enaminones and aldehydes in different media (EtOH/CH3CN).
Metal-free C–H arylation of imidazoheterocycles with aryl hydrazines
Authors: Jana Sourav , Samanta Sadhanendu , Bagdi Avik K. , Shirinian Valerii Z. , Hajra Alakananda
Published: April 2018

Metal-free C–H arylation of imidazo[1,2-a]pyridines at C-3 position with arylhydrazines in presence of DBU has been developed at room temperature under ambient air.
Spontaneous catanionic vesicles formed by the interaction between an anionic β-cyclodextrins derivative and a cationic surfactant
Authors: Silva O. Fernando , de Rossi Rita H. , Correa N. Mariano , Silber Juana J. , Falcone R. Darío
Published: April 2018

Catanionic vesicles containing an anionic β-cyclodextrins derivative and a cationic surfactant.
Ascorbic acid/Fe0 composites as an effective persulfate activator for improving the degradation of rhodamine B
Authors: Wang Xiangyu , Du Yi , Liu Huiling , Ma Jun
Published: April 2018

An ascorbic acid/Fe0 composite (H2A/Fe0)-activated persulfate (PS) process was provided for rhodamine B (RhB) removal.
Effects of single-modification/cross-modification of starch on the mechanical properties of new biodegradable composites
Authors: Chen Shuai , Li Fang-yi , Li Jian-feng , Sun Xu , Cui Jin-feng , Zhang Chuan-wei , Wang Li-ming , Xie Qi , Xu Jie
Published: April 2018

Starch-based composites with different modified starches were prepared by combining starches with sisal fibers to investigate the effects of single-modification/cross-modification of starch on the mechanical properties of new biodegradable composites.
Counting charges on membrane-bound peptides
Authors: McGeachy Alicia C. , Caudill Emily R. , Liang Dongyue , Cui Qiang , Pedersen Joel A. , Geiger Franz M.
Published: April 2018

Quantifying the number of charges on peptides bound to interfaces requires reliable estimates of (i) surface coverage and (ii) surface charge, both of which are notoriously difficult parameters to obtain, especially at solid/water interfaces. Here, we report the thermodynamics and electrostatics governing the interactions ofl-lysine andl-arginine octamers (Lys8and Arg8) with supported lipid bilayers prepared.
Correction: Spectroscopic observation of two-center three-electron bonded (hemi-bonded) structures of (H2S)n+ clusters in the gas phase
Authors: Wang Dandan , Fujii Asuka
Published: April 2018

Correction for ‘Spectroscopic observation of two-center three-electron bonded (hemi-bonded) structures of (H2S)n+ clusters in the gas phase’ by Dandan Wang et al., Chem. Sci., 2017, 8, 2667–2670.
Germanium-incorporated lithium silicate composites as highly efficient low-temperature sorbents for CO2 capture
Authors: Subha P. V. , Nair Balagopal N. , Visakh V. , Sreerenjini C. R. , Mohamed A. Peer , Warrier K. G. K. , Yamaguchi T. , Hareesh U. S.
Published: April 2018

Germanium-incorporated lithium silicate nanostructures with exceptional carbon dioxide absorption kinetics and capacity in the temperature range of 150–700 °C.
Selective edge functionalization of graphene layers with oxygenated groups by means of Reimer–Tiemann and domino Reimer–Tiemann/Cannizzaro reactions
Authors: Barbera Vincenzina , Brambilla Luigi , Porta Alessandro , Bongiovanni Roberta , Vitale Alessandra , Torrisi Giulio , Galimberti Maurizio
Published: April 2018

Graphene layers were selectively edge-functionalized maintaining their bulk structure unaltered.
A novel repeated self-healing epoxy composite with alginate multicore microcapsules
Authors: Lee Hia Iee , Chan Eng-Seng , Chai Siang-Piao , Pasbakhsh Pooria
Published: April 2018

An epoxy (diglycidyl ether of bisphenol A) and a hardener (mercaptan/tertiary amine) were encapsulated within alginate biopolymer to form self-healing multicore microcapsules.
A hypoxia-specific and mitochondria-targeted anticancer theranostic agent with high selectivity for cancer cells
Authors: Hu Mingxing , Yang Chao , Luo Yi , Chen Fan , Yang Fangfang , Yang Shuping , Chen Hao , Cheng Zhiqiang , Li Kun , Xie Yongmei
Published: April 2018

A novel hypoxia-specific and mitochondria-targeted theranostic agent,HMX-1, was reported with certified anti-cancer efficiencyin vitroandin vivo.
Herztransplantation und „Destination“-Therapie – Update 2018
Authors: Saeed Diyar , Westenfeld Ralf
Published: April 2018

Was ist neu?

Zurückhaltung bei der Organspende Der auch im vergangenen Jahr deutliche Rückgang der Bereitschaft zur Organspende hat Auswirkungen auf die Therapie der terminalen Herzinsuffizienz. Wenn auch die Herztransplantation weiterhin den Goldstandard darstellt, kann infolge des Organmangels nur ein geringer und zumeist schwersterkrankter Anteil der Wartelistenpatienten, sogenannte „high-urgent“-Kandidaten mit einem Spenderorgan versorgt werden.

Listung zur Herztransplantation und Kunstherzversorgung Für die Indikationsstellung zur Listung wie zur Kunstherzversorgung gelten ähnliche Kriterien. Aktuelle Leitlinien betonen die valide Aussagekraft von Überlebens-Scores wie dem Heart Failure Survival Score oder dem Seattle Heart Failure Model als Indikator einer kritisch verkürzten Überlebenszeit im Vergleich zu den aufwendiger zu erhebenden etablierten Grenzwerten einer reduzierten spiroergometrischen Belastbarkeit.

Lebenserwartung nach Herztransplantation Im Eurotransplant-Raum liegt die Lebenserwartung nach Herztransplantation seit Jahren stabil im Mittel bei 11 Jahren (1-Jahresüberleben: 80 %). Das durchschnittliche Spenderalter liegt bei 45 Jahren im Vergleich zu deutlich jüngeren 25 Jahren in den USA.

Überleben nach LVAD-Implantation Das Überleben hat sich mit dem Umstieg von pulsatilen auf kontinuierliche Pumpensysteme und parallel zu technischen Innovationen verbessert, sodass das aktuelle 1-Jahresüberleben mit 80 % dem der Herztransplantation ebenbürtig ist. Komplikationen im Langzeitverlauf sind Blutungskomplikationen und Driveline-Infekte. Schlaganfälle (ischämisch und hämorrhagisch) sind mit den aktuellen Systemen auf etwa 3 Fälle in 100 Patientenmonaten reduziert.

Indikationsstellung zur dauerhaften LVAD-Versorgung Besondere Gesichtspunkte beinhalten die Charakterisierung der Rechtsherzfunktion und einer möglichen Aorteninsuffizienz, die bei der Technik der Implantation zu berücksichtigen sind (transiente Rechtsherzunterstützung, bzw. Bioaortenklappenersatz).

Ausblick In der Zukunft werden die begrenzten Organe wahrscheinlich nicht nur nach der Dringlichkeit (berechnet nach der kalkulierten Wartelistensterblichkeit) sondern auch unter Berücksichtigung des zu erwartenden Transplantationserfolges vergeben, die beide im sogenannten Cardiac Allocation Score (CAS) verknüpft sind und mit dessen Implementation ab Mitte 2018 wieder vermehrt elektive Wartelistenpatienten auf ein Spenderherz hoffen könnten.
Neues zur Labordiagnostik bei ANCA-assoziierten Vaskulitiden
Authors: Csernok Elena
Published: April 2018

Was ist neu?

Relevanz der Detektionsmethoden Als Standard zum Nachweis von antineutrophilen zytoplasmatischen Antikörpern (ANCA) galt bis dato die indirekte Immunfluoreszenz (IIF) gefolgt von PR3- und/oder MPO-ANCA-Immunoassay. Neuere Studien haben allerdings gezeigt, dass die Verwendung von antigenspezifischen Immunoassays als einzigem Diagnoseschritt eine bessere Option darstellt.

Aktuelle Entwicklungen in der ANCA-Methodik Neben ELISA sind heute neue Festphasentechnologien (ALBIA, CLIA, FEIA, LIA/DIA) und automatisierte IIF-Assays verfügbar. Derzeit erhältliche Immunoassays für PR3- und MPO-ANCA sind hoch sensitiv und hochspezifisch für die Diagnose einer GPA und MPA.

EUVAS-Studie zur Evaluation von ANCA IIF und antigen-spezifischer Immunoassays In einer aktuellen multizentrischen Studie der European Vasculitis Study Group (EUVAS) wurde die Bedeutung der IIF-Methode im Vergleich zu antigenspezifischen Immunoassays für den ANCA-Nachweis untersucht. Die Ergebnisse bestätigen, dass die diagnostische Wertigkeit der PR3- und MPO-ANCA-Immunoassays der IIF überlegen ist. Auf Basis dieser Daten wurden jüngst neue Leitlinien zur ANCA-Testung erarbeitet.

Neue Konsensus zur ANCA-Diagnostik Die neue internationale Konsensus-Empfehlung wurde 2017 erarbeitet. Sie beinhaltet, dass PR3- und MPO-ANCA-Immunoassays für die korrekte Diagnosestellung bei AAV ohne die Notwendigkeit einer zusätzlichen IIF eingesetzt werden können.

Rationaler Einsatz der ANCA-Testung Wegen der ausgesprochenen Seltenheit der AAV spielt die Vortestwahrscheinlichkeit bei der ANCA-Diagnostik eine besonders große Rolle. ANCA sollten demnach nur bei einer mindestens mittleren Vortestwahrscheinlichkeit eingesetzt werden, d. h. wenn ein klinisch begründeter Verdacht auf das Vorliegen einer Vaskulitis besteht.
Identification of Non-Zinc Binding Inhibitors of MMP-2 Through Virtual Screening and Subsequent Rescoring
Authors: Shamsara Jamal
Published: April 2018

MMP-2 belongs to a large family of proteases called matrix metalloproteinases (MMPs) that degrades type IV collagen, the main structural component of basement membranes and gelatin. The main pathologic role of MMP-2 overexpression is to contribute to the development of cancer through the progression of metastasis and angiogenesis. A structure-based virtual screening was employed to find new inhibitors with possible selectivity for MMP-2. The inhibitory activities of 3 inhibitors (one was not a suitable drug-like hit) among 19 purchased compounds were approved by enzyme inhibition assay. 5 hits were non-zinc-binding inhibitors of MMP-2. The results demonstrated that a computer-aided drug design could be successfully applied for discovering new MMP-2 inhibitors. We found inhibitors with new scaffolds for the inhibition of MMP-2 with some selectivity features that could be used for future lead optimization processes. According to the docked pose and MD simulation, compound 13 was expected to interact with the S1′ specificity loop of MMP-2 and had 2 π–π interactions and a stable hydrogen bond with the MMP-2 active site. The key feature of compound 13 could be used to guide the design of new non-zinc-binding inhibitors of MMP-2.
Prediction of Post-Discharge Bleeding in Elderly Patients with Acute Coronary Syndromes: Insights from the BleeMACS Registry
Authors: Garay Alberto , Formiga Francesc , Raposeiras-Roubín Sergio , Abu-Assi Emad , Sánchez-Salado José , Lorente Victòria , Alegre Oriol , Henriques Jose , D'Ascenzo Fabrizio , Saucedo Jorge , González-Juanatey José , Wilton Stephen , Kikkert Wouter , Nuñez-Gil Iván , Song Xiantao , Alexopoulos Dimitrios , Liebetrau Christoph , Kawaji Tetsuma , Moretti Claudio , Huczek Zenon , Nie Shao-Ping , Fujii Toshiharu , Correia Luis , Kawashiri Masa-aki , García-Acuña José , Southern Danielle , Alfonso Emilio , Terol Belén , Zhang Dongfeng , Chen Yalei , Xanthopoulou Ioanna , Osman Neriman , Möllmann Helge , Shiomi Hiroki , Giordana Francesca , Gaita Fiorenzo , Kowara Michal , Filipiak Krzysztof , Wang Xiao , Yan Yan , Fan Jing-Yao , Ikari Yuji , Nakahashi Takuya , Sakata Kenji , Yamagishi Masakazu , Kalpak Oliver , Kedev Sasko , Cequier Angel , Ariza-Solé Albert
Published: April 2018

Background A poor ability of recommended risk scores for predicting in-hospital bleeding has been reported in elderly patients with acute coronary syndromes (ACS). No study assessed the prediction of post-discharge bleeding in the elderly. The new BleeMACS score (Bleeding complications in a Multicenter registry of patients discharged with diagnosis of Acute Coronary Syndrome), was designed to predict post-discharge bleeding in ACS patients. We aimed to assess the predictive ability of the BleeMACS score in elderly patients.

Methods We assessed the incidence and characteristics of severe bleeding after discharge in ACS patients aged ≥ 75 years. Bleeding was defined as any intracranial bleeding or bleeding leading to hospitalization and/or red blood transfusion, occurring within the first year after discharge. We assessed the predictive ability of the BleeMACS score according to age by Fine–Gray proportional hazards regression analysis, calculating receiver-operating characteristic (ROC) curves and the area under the ROC curves (AUC).

Results The BleeMACS registry included 15,401 patients of whom 3,376/15,401 (21.9%) were aged ≥ 75 years. Elderly patients were more commonly treated with clopidogrel and less often treated with ticagrelor or prasugrel. Of 3,376 elderly patients, 190 (5.6%) experienced post-discharge bleeding. The incidence of bleeding was moderately higher in elderly patients (hazard ratio [HR], 2.31, 95% confidence interval [CI], 1.92–2.77). The predictive ability of the BleeMACS score was moderately lower in elderly patients (AUC, 0.652 vs. 0.691, p = 0.001).

Conclusion Elderly patients with ACS had a significantly higher incidence of post-discharge bleeding. Despite a lower predictive ability in older patients, the BleeMACS score exhibited an acceptable performance in these patients.
Type of Combined Contraceptives, Factor V Leiden Mutation and Risk of Venous Thromboembolism
Authors: Hugon-Rodin Justine , Horellou Marie-Hélène , Conard Jacqueline , Gompel Anne , Plu-Bureau Geneviève
Published: April 2018

Objective This article estimates the interaction between types of combined hormonal contraception (CHC) and factor V Leiden (FVL) mutation on the risk of venous thrombosis event (VTE).

Subjects and Methods All premenopausal women with first incident VTE who were referred to our unit (Paris, France) between 2000 and 2009 were included in this case-only study. Differences in interactions by progestin type were assessed on a multiplicative scale, assuming the independence of genotype and prescription of type of CHC.

Results Among 2,613 women with VTE, 15.9% had a FVL and 69% used CHC. The interaction between CHC use and presence of FVL on VTE risk was statistically significant (1.37, 1.06–1.77 95% confidence interval [CI]). This interaction appeared higher for drospirenone 1.99 (1.18–3.38 95% CI) (n = 98) or cyproterone acetate users 1.71 (1.20–2.45 95% CI) (n = 326), but not significant for 1st or 2nd or norgestimate CHC users. The results were similar when excluding women with a family history of VTE or with provoked VTE. In this sub-group of women, these interactions appeared higher for third generation, cyproterone acetate and drospirenone CHC users as compared with 1st or 2nd or norgestimate CHC users (odds ratio [OR], 1.68 [1.04–2.70; 95% CI], 2.91 [1.71–4.95 95% CI], 3.22 [1.54–6.73 95% CI], respectively).

Conclusion Our results show that the interaction between FVL and CHC use differ by progestin type, which is higher in CHC containing third-generation progestin, drospirenone or cyproterone acetate, compared with second generation. Further studies are needed to assess the cost-effectiveness of biological thrombophilia screening (FVL) when such prescription of CHC is planned.
Kardiopulmonale Reanimation: Was ist neu?
Authors: Michels Guido , Busch Hans-Jörg
Published: April 2018

Was ist neu?

Update Europäische Leitlinien Erstmals haben die europäischen Leitlinien zur kardiopulmonalen Reanimation durch die Stellungnahme der ILCOR im Dezember 2017 ein Update erfahren. Diese sollen nun auch außerhalb des bewährten 5-Jahres-Zyklus möglich sein, wenn neue Daten und Erkenntnisse wesentliche Änderungen der Leitlinien notwendig machen.

Vorgehen bei Reanimation So wird nun empfohlen, dass je nach Abhängigkeit vom Ausbildungsstand des Laienhelfers eine alleinige Thoraxkompression oder eine solche in Kombination mit Atemspenden erfolgen soll. Die wichtige Funktion der Leitstellendisponenten im Rahmen der Telefonreanimation wird nochmals durch die Forderung nach einem strukturierten Training zur Telefonreanimation für Leitstellendisponenten hervorgehoben. Der Einsatz von mechanischen Reanimationshilfen bleibt weiterhin nur besonderen Situationen vorbehalten.
Wave energy resource assessment around Kyushu based on numerical hindcast
Authors: Hirakawa T.
Published: April 2018

After the disaster in the Tohoku region of Japan, as a part of recovery projects, wave energy has been drawing attention. To promote wave energy technologies, including wave energy converters (WECs), this study aims to present comprehensive analyses of wave climates around Kyushu, which is the southernmost and third largest of Japan's four main islands. This paper calculates wave climate around Kyushu for ten years (2007–2016) using the Simulating WAves Nearshore model with an approximately 800 m high spatial and 1-h temporal resolution. The results reveal that the south side of Kyushu has more energetic waves than the north and the southeast has the strongest energy among neighboring seas of Kyushu. In the southeast, the major portion of the wave energy transport is generated by extreme weather events. Wave climates in the southwest are less affected by extreme weather events, and the wave energy transport shows the opposite tendency to that of the southeast, suggesting that wave energy production in the southeast and southwest can supply high stable energy. Statistical wave characteristics in the southeast and southwest also show markedly different tendencies to each other, which provides vital information for future designing, deploying, and tuning of WECs on the south side of Kyushu.
Revealing charge carrier dynamics in squaraine:[6, 6]-phenyl-C 71-butyric acid methyl ester based organic solar cells
Authors: Rana Aniket , Sharma Chhavi , Prabhu Deepak D. , Kumar Mahesh , Karuvath Yoosaf , Das Suresh , Chand Suresh , Singh Rajiv K.
Published: April 2018

Ultrafast charge carrier dynamics as well as the generation of polaron pair in squaraine (SQ) and squaraine:[6,6]-phenyl-C 71-butyric acid methyl ester (SQ:PCBM71) have been studied using ultrafast transient absorption spectroscopy (UTAS). The current study reveals that the pure SQ exhibits the creation of singlet and triplet states; however, incorporation of PCBM71 in SQ results in the formation of polaron pairs with ∼550ps lifetime, which in turn leads to the creation of free electrons in the device. We show that the considerable increment in monomolecular and bimolecular recombination in SQ:PCBM71 compared to pure SQ which describes the interfacial compatibility of SQ and PCBMC71 molecules. The present work not only provides the information about the carrier generation in SQ and SQ:PCBM71 but also gives the facts relating to the effect of PCBM71 mixing into the SQ which is very significant because the SQ has donor-acceptor-donor (D-A-D) structure and mixing one more acceptor can introduce more complex recombinations in the blend. These findings have been complimented by the charge transport study in the device using impedance spectroscopy. The various important transport parameters are transit time (τt), diffusion constant (Dn), global mobility (μ) and carrier lifetime (τr). The values of these parameters are 26.38 μs, 4.64x10-6 cm2s-1, 6.12x10-6 cm2V-1s-1 and 399 μs, respectively. To the best of our knowledge such study related to SQ is not present in the literature comprehensively.