bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Methods and Supplementary Figure 1-20 from SIX1 Promotes Tumor Lymphangiogenesis by Coordinating TGFβ Signals That Increase Expression of VEGF-C
Authors: Liu Dan , Li Li , Zhang Xiao-Xue , Wan Dong-Yi , Xi Bi-Xin , Hu Zheng , Ding Wen-Cheng , Zhu Da , Wang Xiao-Li , Wang Wei , Feng Zuo-Hua , Wang Hui , Ma Ding , Gao Qing-Lei
Published: April 2023

Supplementary Methods and Supplementary Figure 1-20: Supplementary Figure 1 shows the growth of the tumors after orthotopic transplantation. Supplementary Figure 2 shows that over-expression of SIX1 promotes lymphangiogenesis and lymph-node metastasis of C33a cells in vivo. Supplementary Figure 3 shows the assay of cytokine and growth factor with antibody-based array. Supplementary Figure 4 shows the expression of the genes coding for the lymphangiogenic factors. Supplementary Figure 5 shows that SIX1 promotes VEGF-C expression in C33a cells. Supplementary Figure 6 shows that SIX1 promotes migration and tube-formation of HLECs. Supplementary Figure 7 shows the knock-down of VEGF-C in cervical cancer cells. Supplementary Figure 8 shows that the promotional effect of SIX1-expressing tumor cells on the migration and tube-formation of HLECs in vitro is mediated by VEGF-C. Supplementary Figure 9 shows that the promotional effect of SIX1-expressing tumor cells on lymphangiogenesis in vivo is mediated by VEGF-C. Supplementary Figure 10 shows that the promotional effect of SIX1-expressing C33a cells on lymphatic-vessel is mediated by VEGF-C. Supplementary Figure 11 shows that the promotional effect of SIX1 on lymph-node metastasis in vivo is mediated by VEGF-C. Supplementary Figure 12 shows the differences in gene expression levels between tumors in vivo and tumor cells cultured in vitro. Supplementary Figure 13 shows the immunohistochemical analysis of TGF-βs in tissue microarray of human CSCC specimens. Supplementary Figure 14 shows that SIX1 enhances the effect of TGF-β1 on VEGF-C production by tumor cells and tube-formation of HLECs in vitro. Supplementary Figure 15 shows that TGF-β contributes to the differences in VEGF-C expression between tumors in vivo and tumor cells cultured in vitro. Supplementary Figure 16 shows that TGF-β signaling is required for SIX1 to promote lymphangiogenesis and lymph-node metastasis in vivo. Supplementary Figure 17 shows that knocking down the expression of SMAD2 or SMAD3 or TβR1 suppresses TGF-β1 induced VEGF-C expression. Supplementary Figure 18 shows that higher expression of SIX1 correlates with higher expression of TβR1 in human CSCC specimens. Supplementary Figure 19 shows the binding of SIX1 to the VEGF-C promoter. Supplementary Figure 20 shows that knocking down the expression of SMAD2 and SMAD3 does not affect the binding of SIX1 to the VEGF-C promoter.
Data Supplement from Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying
Published: April 2023

Supplementary Table S3. Supplementary data for mutation discovery in canine MCs by WES and RNA-seq analyses, including read mapping information, mutated gene listed, base substitution type, etc.
Data Supplement from Molecular Homology and Difference between Spontaneous Canine Mammary Cancer and Human Breast Cancer
Authors: Liu Deli , Xiong Huan , Ellis Angela E. , Northrup Nicole C. , Rodriguez Carlos O. , O'Regan Ruth M. , Dalton Stephen , Zhao Shaying
Published: April 2023

Supplementary Table S4. Supplementary data for differentially expressed genes among canine complex carcinomas, simple carcinomas and normal tissues, including the gene list and enriched functions among the genes.
Supplementary Figure 1 from Gene Profiling of Canine B-Cell Lymphoma Reveals Germinal Center and Postgerminal Center Subtypes with Different Survival Times, Modeling Human DLBCL
Authors: Richards Kristy L. , Motsinger-Reif Alison A. , Chen Hsiao-Wei , Fedoriw Yuri , Fan Cheng , Nielsen Dahlia M. , Small George W. , Thomas Rachael , Smith Chris , Dave Sandeep S. , Perou Charles M. , Breen Matthew , Borst Luke B. , Suter Steven E.
Published: April 2023

PDF file - 2708K, Immunohistochemistry of cBCLs.
Supplementary Table S1 from Novel Paracrine Modulation of Notch–DLL4 Signaling by Fibulin-3 Promotes Angiogenesis in High-Grade Gliomas
Authors: Nandhu Mohan S. , Hu Bin , Cole Susan E. , Erdreich-Epstein Anat , Rodriguez-Gil Diego J. , Viapiano Mariano S.
Published: April 2023

Antibodies used for Western blotting and immunohistochemistry.
Supplementary information from Cellular Disposal of miR23b by RAB27-Dependent Exosome Release Is Linked to Acquisition of Metastatic Properties
Authors: Ostenfeld Marie Stampe , Jeppesen Dennis K. , Laurberg Jens R. , Boysen Anders T. , Bramsen Jesper B. , Primdal-Bengtson Bjarke , Hendrix An , Lamy Philippe , Dagnaes-Hansen Frederik , Rasmussen Mads H. , Bui Khan H. , Fristrup Niels , Christensen Erik I. , Nordentoft Iver , Morth Jens P. , Jensen Jørgen B. , Pedersen Jakob S. , Beck Martin , Theodorescu Dan , Borre Michael , Howard Kenneth A. , Dyrskjøt Lars , Ørntoft Torben Falck
Published: April 2023

Supplementary materials&methods and figure legends for supplementary figures and tables.
Supplementary Figure S3 from PRMT7 Induces Epithelial-to-Mesenchymal Transition and Promotes Metastasis in Breast Cancer
Authors: Yao Ruosi , Jiang Hao , Ma Yuhui , Wang Liping , Wang Lin , Du Juan , Hou Pingfu , Gao Yanyan , Zhao Li , Wang Guannan , Zhang Yu , Liu Dong-Xu , Huang Baiqu , Lu Jun
Published: April 2023

PRMT7 enhanced migration and invasion in other cell lines.
Supplementary Figure 4 from Flotillin-1 Regulates Oncogenic Signaling in Neuroblastoma Cells by Regulating ALK Membrane Association
Authors: Tomiyama Arata , Uekita Takamasa , Kamata Reiko , Sasaki Kazuki , Takita Junko , Ohira Miki , Nakagawara Akira , Kitanaka Chifumi , Mori Kentaro , Yamaguchi Hideki , Sakai Ryuichi
Published: April 2023

PDF file - 102KB, Supplementary Figure S4. FLOT1, but not clathrin and caveolin, regulates ALK endocytosis upstream of lysosomal degradation.
Supplementary Table S5 from Complex Formation and Function of Estrogen Receptor α in Transcription Requires RIP140
Authors: Rosell Meritxell , Nevedomskaya Ekaterina , Stelloo Suzan , Nautiyal Jaya , Poliandri Ariel , Steel Jennifer H. , Wessels Lodewyk F.A. , Carroll Jason S. , Parker Malcolm G. , Zwart Wilbert
Published: April 2023

Supplementary Table S5. Clinicopathological parameters of patient series.
Data Supplement from IDH1 R132H Mutation Generates a Distinct Phospholipid Metabolite Profile in Glioma
Authors: Esmaeili Morteza , Hamans Bob C. , Navis Anna C. , van Horssen Remco , Bathen Tone F. , Gribbestad Ingrid S. , Leenders William P. , Heerschap Arend
Published: April 2023

Suppl. Figure 1 consists of 1D NMR spectra (A) and 2D NMR spectra (B) which is demonstrated in 2 slides. Suppl. Figure 2 demonstrates the evaluation of proliferation in the glioma xenograft models. Suppl. Figure 3 shows western blot analysis IDH1 and IDH1-R132H proteins in U251 glioma cell lines.
Supplementary Figure 4 from miR326 Maturation Is Crucial for VEGF-C–Driven Cortactin Expression and Esophageal Cancer Progression
Authors: Hong Chih-Chen , Chen Pai-Sheng , Chiou Jean , Chiu Ching-Feng , Yang Ching-Yao , Hsiao Michael , Chang Yi-Wen , Yu Yang-Hao , Hung Mien-Chie , Hsu Nai-Wen , Shiah Shine-Gwo , Hsu Nan-Yung , Su Jen-Liang
Published: April 2023

Supplementary Figure 4. The mRNA expression of miR-326 in TE-8 cells with knockdown of VEGFR-3. TE-8 cells were transiently transfected shVEGFR-3#1, #2 or shCtrl for 48 hours and isolated total RNA to assay. A, qRT-PCR was used to quantify the expression level of miR-326 in those indicated cells. B, RT-PCR was showed the expression level of VEGFR-3 in those indicated cells. GAPDH was used as an internal control. The quantities values were evaluated as percentage compared with TE-8/shCtrl cells. The columns are the mean values from three independent experiments. Bars indicate means {plus minus} SE.
Supplementary Figure Legends from Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Authors: Xu Jinfei , Kadariya Yuwaraj , Cheung Mitchell , Pei Jianming , Talarchek Jacqueline , Sementino Eleonora , Tan Yinfei , Menges Craig W. , Cai Kathy Q. , Litwin Samuel , Peng Hongzhuang , Karar Jayashree , Rauscher Frank J. , Testa Joseph R.
Published: April 2023

PDF file - 64K
Supplementary Figure 3 from Germline Mutation of Bap1 Accelerates Development of Asbestos-Induced Malignant Mesothelioma
Authors: Xu Jinfei , Kadariya Yuwaraj , Cheung Mitchell , Pei Jianming , Talarchek Jacqueline , Sementino Eleonora , Tan Yinfei , Menges Craig W. , Cai Kathy Q. , Litwin Samuel , Peng Hongzhuang , Karar Jayashree , Rauscher Frank J. , Testa Joseph R.
Published: April 2023

PDF file - 576K, Supplementary Figure 3. A, lower magnification view showing intestinal architecture of MM invasion into smooth muscle of intestinal wall. B, higher magnification view of invading tumor cells corresponding to area within rectangle in panel A.
Supplementary Figure 1 from NGF Blockade at Early Times during Bone Cancer Development Attenuates Bone Destruction and Increases Limb Use
Authors: McCaffrey Gwen , Thompson Michelle L. , Majuta Lisa , Fealk Michelle N. , Chartier Stephane , Longo Geraldine , Mantyh Patrick W.
Published: April 2023

Supplementary Figure 1. Patella displacement is a confounding factor in bone cancer pain.
Supplementary Figure Legends from Natural Killer Cells Are Essential for the Ability of BRAF Inhibitors to Control BRAFV600E-Mutant Metastatic Melanoma
Authors: Ferrari de Andrade Lucas , Ngiow Shin F. , Stannard Kimberley , Rusakiewicz Sylvie , Kalimutho Murugan , Khanna Kum Kum , Tey Siok-Keen , Takeda Kazuyoshi , Zitvogel Laurence , Martinet Ludovic , Smyth Mark J.
Published: April 2023

Supp Figure Legends
Supplementary Table 2 from O-GlcNAc Transferase Integrates Metabolic Pathways to Regulate the Stability of c-MYC in Human Prostate Cancer Cells
Authors: Itkonen Harri M. , Minner Sarah , Guldvik Ingrid J. , Sandmann Mareike Julia , Tsourlakis Maria Christina , Berge Viktor , Svindland Aud , Schlomm Thorsten , Mills Ian G.
Published: April 2023

XLSX - 460K, Expression profiles induced by targeting OGT and ontology enrichment analysis of the genes downregulated by OGT inhibitor.
Data Supplement from Cryotherapy with Concurrent CpG Oligonucleotide Treatment Controls Local Tumor Recurrence and Modulates HER2/neu Immunity
Authors: Veenstra Jesse J. , Gibson Heather M. , Littrup Peter J. , Reyes Joyce D. , Cher Michael L. , Takashima Akira , Wei Wei-Zen
Published: April 2023

Supplementary Figure S3. (A) Experimental scheme. Sera and tumor measurements were collected from BALB/c mice on days 0, 8, 17, 24, and 30 (n= 9). (B) α-Her2 IgG levels were quantified from sera and correlated with tumor volume. Mean D2F2/E2 volume (mm3) and α-Her2 IgG (Ab5 equivalent μg/mL) are plotted on the left and right y-axis respectively. (C) Three mice were euthanized at day 17 to collect spleens for IFN-γ ELISPOT. Splenocytes were isolated and stimulated with either EKB or KB 3T3 lines for 48hr (n=3/group). **P<0.01 Unpaired t-test.
Supplementary Figure S7 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: April 2023

Supplementary Figure S7. Analysis of CtBP2 function for PTEN promoter repression by androgen.
Supplementary Figure S6 from CtBP2 Modulates the Androgen Receptor to Promote Prostate Cancer Progression
Authors: Takayama Ken-ichi , Suzuki Takashi , Fujimura Tetsuya , Urano Tomohiko , Takahashi Satoru , Homma Yukio , Inoue Satoshi
Published: April 2023

Supplementary Figure S6. CtBP2 negatively regulates FOXO1 promoter activation
Supplementary Video #6 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

A single MDA-MB-231 breast cancer cell intravasating into an HMVEC vessel under shear stress (12-15 dyne cm-2).
Supplementary Video #5 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

A single MDA-MB-231 breast cancer cell invading and intravasating into an HMVEC vessel under shear stress (12-15 dyne cm-2).
Supplementary Video #1 from Live-Cell Imaging of Invasion and Intravasation in an Artificial Microvessel Platform
Authors: Wong Andrew D. , Searson Peter C.
Published: April 2023

Phase-contrast movie of a HUVEC microvessel under shear stress (12-15 dyne cm-2).
Supplemental Figure S4 from Transient SNAIL1 Expression Is Necessary for Metastatic Competence in Breast Cancer
Authors: Tran Hung D. , Luitel Krishna , Kim Michael , Zhang Kun , Longmore Gregory D. , Tran David D.
Published: April 2023

Supplemental Figure S4. Related to Figure 3: SNAIL1 expression in primary breast tumors precedes detection of DTCs, but SNAIL1 is not expressed by DTCs and lung metastases in MMTV-PyMT mice
Supplementary Figure 2 from Molecular Modulation of Estrogen-Induced Apoptosis by Synthetic Progestins in Hormone Replacement Therapy: An Insight into the Women's Health Initiative Study
Authors: Sweeney Elizabeth E. , Fan Ping , Jordan V. Craig
Published: April 2023

Supplementary Figure 2. MCF-7:5C cells were treated with Dex (A), MPA (B), or NETA (C) at concentrations ranging from 10-10 M to 10-6 M for seven days, and DNA was quantified.
Figure S1 Identification of rapamycin collaborators through small molecule high-throughout screening from mTORC1-Driven Tumor Cells Are Highly Sensitive to Therapeutic Targeting by Antagonists of Oxidative Stress
Authors: Li Jing , Shin Sejeong , Sun Yang , Yoon Sang-Oh , Li Chenggang , Zhang Erik , Yu Jane , Zhang Jianming , Blenis John
Published: April 2023

Synergism analysis between BSO and rapamycin in Tsc2-/- MEFs
Data Supplement from CSF1/CSF1R Blockade Reprograms Tumor-Infiltrating Macrophages and Improves Response to T-cell Checkpoint Immunotherapy in Pancreatic Cancer Models
Authors: Zhu Yu , Knolhoff Brett L. , Meyer Melissa A. , Nywening Timothy M. , West Brian L. , Luo Jingqin , Wang-Gillam Andrea , Goedegebuure S. Peter , Linehan David C. , DeNardo David G.
Published: April 2023

Figure S1. Flow cytometric analysis of leukocyte infiltration in orthotopic PDAC tumors. Figure S2. CSF1 blockade depletes CD206+ Mo-MDSCs and upregulates MHCII expression in Lymphoid DCs. Figure S3. A-B) Mice bearing orthotopic KC. Table S1. Gene lists from array analysis are depicted. Lists were selected by fold change > or < 1.5, pvalue <0.05, and q-value <0.25. n=6 mice/group for a total of 12 arrays.
Supplementary Figure 4 from A Hypusine–eIF5A–PEAK1 Switch Regulates the Pathogenesis of Pancreatic Cancer
Authors: Fujimura Ken , Wright Tracy , Strnadel Jan , Kaushal Sharmeela , Metildi Cristina , Lowy Andrew M. , Bouvet Michael , Kelber Jonathan A. , Klemke Richard L.
Published: April 2023

Contains additional data on PEAK1 expression and gemcitabine sensitivity.
Supplementary Figure 3 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: April 2023

Supplementary Figure 3. The relationship between Notch1 and miR-34 family members.
Supplementary Figure 1 from Targeting of miR34a–NOTCH1 Axis Reduced Breast Cancer Stemness and Chemoresistance
Authors: Park Eun Young , Chang EunSun , Lee Eun Ji , Lee Hyun-Woo , Kang Hyeok-Gu , Chun Kyung-Hee , Woo Yu Mi , Kong Hyun Kyung , Ko Je Yeong , Suzuki Hiromu , Song Erwei , Park Jong Hoon
Published: April 2023

Supplementary Figure 1. Expression levels of cancer stem cell markers in tumorsphere cells.
Data Supplement from Validation and Structural Characterization of the LEDGF/p75–MLL Interface as a New Target for the Treatment of MLL-Dependent Leukemia
Authors: Čermáková Kateřina , Tesina Petr , Demeulemeester Jonas , El Ashkar Sara , Méreau Hélène , Schwaller Juerg , Řezáčová Pavlína , Veverka Vaclav , De Rijck Jan
Published: April 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Data Supplement from Armed Oncolytic Virus Enhances Immune Functions of Chimeric Antigen Receptor–Modified T Cells in Solid Tumors
Authors: Nishio Nobuhiro , Diaconu Iulia , Liu Hao , Cerullo Vincenzo , Caruana Ignazio , Hoyos Valentina , Bouchier-Hayes Lisa , Savoldo Barbara , Dotti Gianpietro
Published: April 2023

Supplementary Figure S3. Growth of CHLA-255 cells in control mice
Supplementary Tables 1 - 7 from Discrepancies in Cancer Genomic Sequencing Highlight Opportunities for Driver Mutation Discovery
Authors: Hudson Andrew M. , Yates Tim , Li Yaoyong , Trotter Eleanor W. , Fawdar Shameem , Chapman Phil , Lorigan Paul , Biankin Andrew , Miller Crispin J. , Brognard John
Published: April 2023

Supplementary Table 1A. Mutations that were only identified by CCLE in the comparison of sequencing data of 1630 genes across 568 cell lines from CCLE and COSMIC . Supplementary Table 1B. Mutations that were only identified by COSMIC in the comparison of sequencing data of 1630 genes across 568 cell lines from CCLE and COSMIC. Supplementary Table 2. Sequencing cold spots (larger than 100bp) in cancer consensus and kinase genes identified from sequencing data of 10 CCLE whole exome sequencing files (not hybrid capture). Supplementary Table 3. New mutations detected by CRUK Manchester Institute sequencing that were not reported by either CCLE or COSMIC. Supplementary Table 4. Proportion of missense mutations exclusively reported by one institute (CCLE or COSMIC) that were subsequently found by CRUK MI sequencing. Supplementary Table 5. Sequencing statistics for CRUK MI sequencing. Supplementary Table 6. List of kinase and Cancer Census genes that were analyzed to identify sequencing cold-spots in 10 CCLE whole exome sequencing files Supplementary Table 7 Read coverage in CCLE Hybrid Capture data at the midpoint of the 20 largest cold-spots identified in CCLE from 10 lung whole exome sequencing files (not hybrid capture).
Supplementary Table 7 from Colorectal Cancer Cell Lines Are Representative Models of the Main Molecular Subtypes of Primary Cancer
Authors: Mouradov Dmitri , Sloggett Clare , Jorissen Robert N. , Love Christopher G. , Li Shan , Burgess Antony W. , Arango Diego , Strausberg Robert L. , Buchanan Daniel , Wormald Samuel , O'Connor Liam , Wilding Jennifer L. , Bicknell David , Tomlinson Ian P.M. , Bodmer Walter F. , Mariadason John M. , Sieber Oliver M.
Published: April 2023

XLSX file - 90KB, Top 5% of mutated genes based on the proportion of affected samples in CRC cell lines and TCGA-analyzed primary cancers for non-hypermutated and hypermutated MSI-H samples.
Supplementary Methods and References from PAK1 Tyrosine Phosphorylation Is Required to Induce Epithelial–Mesenchymal Transition and Radioresistance in Lung Cancer Cells
Authors: Kim EunGi , Youn HyeSook , Kwon TaeWoo , Son Beomseok , Kang JiHoon , Yang Hee Jung , Seong Ki Moon , Kim Wanyeon , Youn BuHyun
Published: April 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Tables 1 - 4 from Rapamycin Rescues ABT-737 Efficacy in Small Cell Lung Cancer
Authors: Gardner Eric E. , Connis Nick , Poirier John T. , Cope Leslie , Dobromilskaya Irina , Gallia Gary L. , Rudin Charles M. , Hann Christine L.
Published: April 2023

XLSX file - 138KB, Supplemental Table 1. Tumor sample information, ABT-737 versus vehicle tumors submitted for microarray analysis. Supplemental Table 2. ABT-737 Treatment Response - Differentially Expressed Genes. Supplemental Table 3. ABT-737 Treatment Response - Gene Sets. Supplemental Table 4. Connectivity Map output ranked list.
Supplementary Table S2 from A Small-Molecule Modulator of the Tumor-Suppressor miR34a Inhibits the Growth of Hepatocellular Carcinoma
Authors: Xiao Zhangang , Li Chi Han , Chan Stephen L. , Xu Feiyue , Feng Lu , Wang Yan , Jiang Jian-Dong , Sung Joseph J.Y. , Cheng Christopher H.K. , Chen Yangchao
Published: April 2023

Supplementary Table S2. The full library screening dataset.
Supplemental Figure S5 from H3K9 Histone Methyltransferase, KMT1E/SETDB1, Cooperates with the SMAD2/3 Pathway to Suppress Lung Cancer Metastasis
Authors: Wu Pei-Chun , Lu Jeng-Wei , Yang Jer-Yen , Lin I-Hsuan , Ou Da-Liang , Lin Yu-Hsiang , Chou Kuan-Hsien , Huang Wen-Feng , Wang Wan-Ping , Huang Yih-Leh , Hsu Chiun , Lin Liang-In , Lin Yueh-Min , Shen C.-K. James , Tzeng Tsai-Yu
Published: April 2023

ANXA2 and SMAD3 promotes F-actin polymerization formation in lung cancer cells.
Supplemental Methods and Materials from DUSP1 Phosphatase Regulates the Proinflammatory Milieu in Head and Neck Squamous Cell Carcinoma
Authors: Zhang Xiaoyi , Hyer J. Madison , Yu Hong , D'Silva Nisha J. , Kirkwood Keith L.
Published: April 2023

Supplemental Methods and Materials
Supplementary Methods and References from CDC42 Inhibition Suppresses Progression of Incipient Intestinal Tumors
Authors: Sakamori Ryotaro , Yu Shiyan , Zhang Xiao , Hoffman Andrew , Sun Jiaxin , Das Soumyashree , Vedula Pavan , Li Guangxun , Fu Jiang , Walker Francesca , Yang Chung S. , Yi Zheng , Hsu Wei , Yu Da-Hai , Shen Lanlan , Rodriguez Alexis J. , Taketo Makoto M. , Bonder Edward M. , Verzi Michael P. , Gao Nan
Published: April 2023

Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Figure 4 from Harnessing the Fcμ Receptor for Potent and Selective Cytotoxic Therapy of Chronic Lymphocytic Leukemia
Authors: Vire Bérengère , Skarzynski Martin , Thomas Joshua D. , Nelson Christopher G. , David Alexandre , Aue Georg , Burke Terrence R. , Rader Christoph , Wiestner Adrian
Published: April 2023

Supplementary Figure 4 shows cell surface expression of FcµR on PBMC samples from treatment naïve and relapsed or refractory CLL patients.
Supplemental Figure S2 from CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy
Authors: Soto-Pantoja David R. , Terabe Masaki , Ghosh Arunima , Ridnour Lisa A. , DeGraff William G. , Wink David A. , Berzofsky Jay A. , Roberts David D.
Published: April 2023

Supplemental Figure S2. CD47 blockade enhances T cell mediated cancer cell killing without affecting target cell proliferation.
Supplemental Figure S1 from CD47 in the Tumor Microenvironment Limits Cooperation between Antitumor T-cell Immunity and Radiotherapy
Authors: Soto-Pantoja David R. , Terabe Masaki , Ghosh Arunima , Ridnour Lisa A. , DeGraff William G. , Wink David A. , Berzofsky Jay A. , Roberts David D.
Published: April 2023

Supplemental Figure S1. Suppression of CD47 does not enhance radiation growth delay in and athymic mouse SCC VII model of squamous cell carcinoma.
Supplementary Methods from Microenvironment-Derived HGF Overcomes Genetically Determined Sensitivity to Anti-MET Drugs
Authors: Pennacchietti Selma , Cazzanti Manuela , Bertotti Andrea , Rideout William M. , Han May , Gyuris Jeno , Perera Timothy , Comoglio Paolo M. , Trusolino Livio , Michieli Paolo
Published: April 2023

Supplementary Methods. Supplementary information on drugs and chemicals, human HGF knock-in mice, in vivo signal transduction analysis, study approval, and statistical analysis.
Data Supplement from IL15RA Drives Antagonistic Mechanisms of Cancer Development and Immune Control in Lymphocyte-Enriched Triple-Negative Breast Cancers
Authors: Marra Pierfrancesco , Mathew Sumi , Grigoriadis Anita , Wu Yin , Kyle-Cezar Fernanda , Watkins Johnathan , Rashid Mamunur , De Rinaldis Emanuele , Hessey Sonya , Gazinska Patrycja , Hayday Adrian , Tutt Andrew
Published: April 2023

Supplementary Table S1. List of genes with an absolute copy number of h >=5 for >=25% of TNBCs.
Data Supplement from The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Authors: Watson Ian R. , Li Liren , Cabeceiras Peter K. , Mahdavi Mozhdeh , Gutschner Tony , Genovese Giannicola , Wang Guocan , Fang Zhuangna , Tepper James M. , Stemke-Hale Katherine , Tsai Kenneth Y. , Davies Michael A. , Mills Gordon B. , Chin Lynda
Published: April 2023

Supplementary Figure 2: RAC1 P29S mutant melanoma cell lines have higher levels of activated RAC1.
Supplementary Figure 7 from CD66+ Cells in Cervical Precancers Are Partially Differentiated Progenitors with Neoplastic Traits
Authors: Pattabiraman Chitra , Hong Shiyuan , Gunasekharan Vignesh K. , Pranatharthi Annapurna , Bajaj Jeevisha , Srivastava Sweta , Krishnamurthy H. , Ammothumkandy Aswathy , Giri Venkat G. , Laimins Laimonis A. , Krishna Sudhir
Published: April 2023

Supplementary Figure 7. Hypothetical model for the generation of partially differentiated progenitors in cervical pre-cancers
Data Supplement from The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Authors: Watson Ian R. , Li Liren , Cabeceiras Peter K. , Mahdavi Mozhdeh , Gutschner Tony , Genovese Giannicola , Wang Guocan , Fang Zhuangna , Tepper James M. , Stemke-Hale Katherine , Tsai Kenneth Y. , Davies Michael A. , Mills Gordon B. , Chin Lynda
Published: April 2023

Supplementary Figure 4: Overexpression of RAC1 P29S increases cell viability of A375 to RAF and MEK inhibitor treatment.
Supplementary Figure 5 from CD66+ Cells in Cervical Precancers Are Partially Differentiated Progenitors with Neoplastic Traits
Authors: Pattabiraman Chitra , Hong Shiyuan , Gunasekharan Vignesh K. , Pranatharthi Annapurna , Bajaj Jeevisha , Srivastava Sweta , Krishnamurthy H. , Ammothumkandy Aswathy , Giri Venkat G. , Laimins Laimonis A. , Krishna Sudhir
Published: April 2023

Supplementary Figure 5. Cycling and survival properties of CD66High cells from CIN-612, and CaSki spheroids
Data Supplement from The RAC1 P29S Hotspot Mutation in Melanoma Confers Resistance to Pharmacological Inhibition of RAF
Authors: Watson Ian R. , Li Liren , Cabeceiras Peter K. , Mahdavi Mozhdeh , Gutschner Tony , Genovese Giannicola , Wang Guocan , Fang Zhuangna , Tepper James M. , Stemke-Hale Katherine , Tsai Kenneth Y. , Davies Michael A. , Mills Gordon B. , Chin Lynda
Published: April 2023

Supplementary Figure 5: Overexpression of RAC1 P29S increases cell viability of MALME-3M to RAF inhibitor treatment.
Supplementary Figure 2 from CD66+ Cells in Cervical Precancers Are Partially Differentiated Progenitors with Neoplastic Traits
Authors: Pattabiraman Chitra , Hong Shiyuan , Gunasekharan Vignesh K. , Pranatharthi Annapurna , Bajaj Jeevisha , Srivastava Sweta , Krishnamurthy H. , Ammothumkandy Aswathy , Giri Venkat G. , Laimins Laimonis A. , Krishna Sudhir
Published: April 2023

Supplementary Figure 2. CD66High cells have features of keratinocyte differentiation
Supplemental Information from HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs
Authors: Vernin Céline , Thenoz Morgan , Pinatel Christiane , Gessain Antoine , Gout Olivier , Delfau-Larue Marie-Hélène , Nazaret Nicolas , Legras-Lachuer Catherine , Wattel Eric , Mortreux Franck
Published: April 2023

Supplemental Information. Detailed methods and supplemental figure legends
Supplemental Figure 6 from HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs
Authors: Vernin Céline , Thenoz Morgan , Pinatel Christiane , Gessain Antoine , Gout Olivier , Delfau-Larue Marie-Hélène , Nazaret Nicolas , Legras-Lachuer Catherine , Wattel Eric , Mortreux Franck
Published: April 2023

Supplemental Figure 6. Ectopic miR-17 and miR-21 repress endogenous expression of OBFC2A/hSSB2 transcripts.
Supplemental Figure 2 from HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs
Authors: Vernin Céline , Thenoz Morgan , Pinatel Christiane , Gessain Antoine , Gout Olivier , Delfau-Larue Marie-Hélène , Nazaret Nicolas , Legras-Lachuer Catherine , Wattel Eric , Mortreux Franck
Published: April 2023

Supplemental Figure 2. Expression levels of pri-miR-17 and pri-miR-21 in cloned CD4+ T-cells derived from HTLV-1-infected individuals.
Supplemental Figure 1 from HTLV-1 bZIP Factor HBZ Promotes Cell Proliferation and Genetic Instability by Activating OncomiRs
Authors: Vernin Céline , Thenoz Morgan , Pinatel Christiane , Gessain Antoine , Gout Olivier , Delfau-Larue Marie-Hélène , Nazaret Nicolas , Legras-Lachuer Catherine , Wattel Eric , Mortreux Franck
Published: April 2023

Supplemental Figure 1. A. miRNA expression in cloned T-cells derived from HTLV-1-infected individuals without malignancies. B. Heatmap of expression patterns of 23 miRNAs, Tax and HBZ in 70 clones (34 CD4+) derived from infected individuals.
Supplementary Materials and Methods from Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-Associated Cancer
Authors: Sakurai Toshiharu , Kashida Hiroshi , Watanabe Tomohiro , Hagiwara Satoru , Mizushima Tsunekazu , Iijima Hideki , Nishida Naoshi , Higashitsuji Hiroaki , Fujita Jun , Kudo Masatoshi
Published: April 2023

Supplementary Materials and Methods
Supplementary Figure S2 from Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges
Authors: Hoelzinger Dominique B. , Dominguez Ana Lucia , Cohen Peter A. , Gendler Sandra J.
Published: April 2023

Supplementary Figure S2. Total T cell numbers in tumor bearing WT and IL-9ko mice are similar, whereas levels of CD11 b+Gr1 + cells are higher in 4T1 tumor bearing WT mice.
Supplementary Figure S3 from Stress Response Protein Cirp Links Inflammation and Tumorigenesis in Colitis-Associated Cancer
Authors: Sakurai Toshiharu , Kashida Hiroshi , Watanabe Tomohiro , Hagiwara Satoru , Mizushima Tsunekazu , Iijima Hideki , Nishida Naoshi , Higashitsuji Hiroaki , Fujita Jun , Kudo Masatoshi
Published: April 2023

Figure S3. (A) Representative immunostaining images of colonic mucosa of controls and patients with refractory UC using anti-Sox2 antibody. Scale bar, 50 microm. (B) Representative immunostaining images of colonic mucosa of patients with refractory UC with anti-Cirp and anti-E-cadherin antibodies. (C) Representative immunostaining images of well-moderately differentiated colorectal cancer tissues with anti-Cirp antibody. Scale bar, 100 microm. (D) Representative immunostaining images of colonic mucosa of patients with refractory UC using anti-Dclk1 antibody. Scale bar, 20 microm.
Supplementary Figure Legends from Inhibition of Adaptive Immunity by IL9 Can Be Disrupted to Achieve Rapid T-cell Sensitization and Rejection of Progressive Tumor Challenges
Authors: Hoelzinger Dominique B. , Dominguez Ana Lucia , Cohen Peter A. , Gendler Sandra J.
Published: April 2023

Supplementary Figure Legends. Legend for Supplementary Figures S1-S3.
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Tables 1 through 7 from Oncoprotein HBXIP Modulates Abnormal Lipid Metabolism and Growth of Breast Cancer Cells by Activating the LXRs/SREBP-1c/FAS Signaling Cascade
Authors: Zhao Yu , Li Hang , Zhang Yingyi , Li Leilei , Fang Runping , Li Yinghui , Liu Qian , Zhang Weiying , Qiu Liyan , Liu Fabao , Zhang Xiaodong , Ye Lihong
Published: April 2023

Supplementary Materials and Methods. Table S1. The positive rate of HBXIP is 87.5% (329/376) in 3 groups of atypical duct hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive breast cancer (IBC). Table S2. The expression levels of HBXIP were shown in the tumor tissues. Table S3. The expression and pathological features of HBXIP were shown in 236 clinical breast cancer tissues. Table S4. Cross tabulation analysis of HBXIP and FAS is shown in cancer tissues. Table S5. Primers for promoter of lipid metabolism genes are shown in the table. Table S6. Antibodies are used in this paper. Table S7. Detailed information of tumor tissues was shown in this table.
Supplemental Figures 1-12 from Vaccine-Elicited CD8+ T Cells Cure Mesothelioma by Overcoming Tumor-Induced Immunosuppressive Environment
Authors: Tan Zhiwu , Zhou Jingying , Cheung Allen K.L. , Yu Zhe , Cheung Ka-Wai , Liang Jianguo , Wang Haibo , Lee Boon Kiat , Man Kwan , Liu Li , Yuen Kwok-Yung , Chen Zhiwei
Published: April 2023

Supplementary Figure 1. Construction of two conventional WT1 DNA vaccines and generation of WT1-expressing AB1 malignant mesothelioma cell line. Supplementary Figure 2. Construction of HIV-1 GAG-expressing AB1 malignant mesothelioma cell line. Supplementary Figure 3. Importance of inducing p24-specific cellular responses for AB1-GAG tumor rejection. Supplementary Figure 4. Anti-tumor effect from CD8+ T cells was cross-confirmed in a B16F10 melanoma mouse model. Supplementary Figure 5. Secreted cytokines from CD8+ T cells significantly arrested AB1-GAG tumor cells at G1 phase. Supplementary Figure 6. Gating strategies for flow cytometric scatter plots. Supplementary Figure 7. Analysis of CD8+ T cell subsets in spleen and tumor. Supplementary Figure 8. Analysis of Th2 and exhaustion markers on CD8+ T cells in spleen and tumor. Supplementary Figure 9. Rapid increase of tumor-induced PD-1+CD8+ T, Tim-3+CD8+ T, MDSCs and CD4+ Treg cells. Supplementary Figure 10. Splenic and tumor-infiltrating CD8+ T cells exhibit distinct phenotypic and functional characteristics. Supplementary Figure 11. Correlation analyses of vaccine-elicited CD8+ T cells in therapeutic exp. Supplementary Figure 12. Correlation analyses in adoptive transfer experiments for inhibitory CD8+ T cells and their cytokine function. eriments.
Supplementary Figure Legends from GPER Mediates Activation of HIF1α/VEGF Signaling by Estrogens
Authors: De Francesco Ernestina Marianna , Pellegrino Michele , Santolla Maria Francesca , Lappano Rosamaria , Ricchio Emilia , Abonante Sergio , Maggiolini Marcello
Published: April 2023

PDF file - 96KB
Supplementary Materials and Methods, Figure Legends from hMOB3 Modulates MST1 Apoptotic Signaling and Supports Tumor Growth in Glioblastoma Multiforme
Authors: Tang Fengyuan , Zhang Lei , Xue Gongda , Hynx Debby , Wang Yuhua , Cron Peter D. , Hundsrucker Christian , Hergovich Alexander , Frank Stephan , Hemmings Brian A. , Schmitz-Rohmer Debora
Published: April 2023

PDF file - 138KB
Supplementary Figure 1 from Immune-Based Antitumor Effects of BRAF Inhibitors Rely on Signaling by CD40L and IFNγ
Authors: Ho Ping-Chih , Meeth Katrina M. , Tsui Yao-Chen , Srivastava Bhaskar , Bosenberg Marcus W. , Kaech Susan M.
Published: April 2023

PDF file - 270KB, Supplementary Figure 1. Profile of tumor infiltrating immune cells in BrafV600E/Pten melanomas.
Supplementary Figures S1-S5 from Suppression of Deacetylase SIRT1 Mediates Tumor-Suppressive NOTCH Response and Offers a Novel Treatment Option in Metastatic Ewing Sarcoma
Authors: Ban Jozef , Aryee Dave N.T. , Fourtouna Argyro , van der Ent Wietske , Kauer Max , Niedan Stephan , Machado Isidro , Rodriguez-Galindo Carlos , Tirado Oscar M. , Schwentner Raphaela , Picci Piero , Flanagan Adrienne M. , Berg Verena , Strauss Sandra J. , Scotlandi Katia , Lawlor Elizabeth R. , Snaar-Jagalska Ewa , Llombart-Bosch Antonio , Kovar Heinrich
Published: April 2023

Supplementary Figures S1-S5. MDM4 modulation by HEY1 occurs downstream of TP53 (S1); Modulation of SIRT1 and TP53 induction upon ectopic expression of Flag-tagged HEY1 in the B-cell malignancy cell lines "697" and NALM6, and in primary keratinocytes (S2); The degree of SIRT1 modulation depends on HEY1 levels (S3); Flow-diagram of samples analysed on tissue micro arrays (TMA1, TMA2, TMA3), and FFPE sections used in this study (S4); Kaplan-Meier survival estimates for patients analysed for SIRT1 expression on TMA3 (S5).
Data Supplement from RPA Inhibition Increases Replication Stress and Suppresses Tumor Growth
Authors: Glanzer Jason G. , Liu Shengqin , Wang Ling , Mosel Adam , Peng Aimin , Oakley Greg G.
Published: April 2023

Legend for Supplementary Figure S1.
Supplementary Figure 3 from LASP1 Is a HIF1α Target Gene Critical for Metastasis of Pancreatic Cancer
Authors: Zhao Tiansuo , Ren He , Li Jing , Chen Jing , Zhang Huan , Xin Wen , Sun Yan , Sun Lei , Yang Yongwei , Sun Junwei , Wang Xiuchao , Gao Song , Huang Chongbiao , Zhang Huafeng , Yang Shengyu , Hao Jihui
Published: April 2023

(A) The morphology of Panc-1/pLV vector and Panc-1/pLV LASP-1 cells. (B) LASP-1 expression determined by Western blot analysis in Panc-1/pLV vector andPanc-1/pLV LASP-1 cells.
Supplementary Table 1 from PLZF, a Tumor Suppressor Genetically Lost in Metastatic Castration-Resistant Prostate Cancer, Is a Mediator of Resistance to Androgen Deprivation Therapy
Authors: Hsieh Chen-Lin , Botta Ginevra , Gao Shuai , Li Tiantian , Van Allen Eliezer M. , Treacy Daniel J. , Cai Changmeng , He Housheng Hansen , Sweeney Christopher J. , Brown Myles , Balk Steven P. , Nelson Peter S. , Garraway Levi A. , Kantoff Philip W.
Published: April 2023

Supplementary Table 1. PLZF-regulated transcriptome
Supplementary Table and Figure Legends from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Table and Figure Legends. Legends for Supplementary Tables S1-S2 and Supplementary Figures S1-S6.
Supplementary Table S1 from Kinome-wide Functional Screen Identifies Role of PLK1 in Hormone-Independent, ER-Positive Breast Cancer
Authors: Bhola Neil E. , Jansen Valerie M. , Bafna Sangeeta , Giltnane Jennifer M. , Balko Justin M. , Estrada Mónica V. , Meszoely Ingrid , Mayer Ingrid , Abramson Vandana , Ye Fei , Sanders Melinda , Dugger Teresa C. , Allen Eliezer V. , Arteaga Carlos L.
Published: April 2023

Supplementary Table S1. Off-target effect of ER siRNA on TK-Renilla activity.
Supplementary Movie 4 from Genetic Identification of SEMA3F as an Antilymphangiogenic Metastasis Suppressor Gene in Head and Neck Squamous Carcinoma
Authors: Doçi Colleen L. , Mikelis Constantinos M. , Lionakis Michail S. , Molinolo Alfredo A. , Gutkind J. Silvio
Published: April 2023

Supplementary Movies 3. SEMA3F induces rapid collapse of COS-7 cells transfected with NRP2 and Plexin A3 (Control).
Supplementary Table S2 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations
Authors: Sawai Yugo , Kodama Yuzo , Shimizu Takahiro , Ota Yuji , Maruno Takahisa , Eso Yuji , Kurita Akira , Shiokawa Masahiro , Tsuji Yoshihisa , Uza Norimitsu , Matsumoto Yuko , Masui Toshihiko , Uemoto Shinji , Marusawa Hiroyuki , Chiba Tsutomu
Published: April 2023

Primers of murine DNA Sanger sequencing analysis.
Supplementary Table S3 from IL13 Receptor α2 Signaling Requires a Scaffold Protein, FAM120A, to Activate the FAK and PI3K Pathways in Colon Cancer Metastasis
Authors: Bartolomé Rubén A. , García-Palmero Irene , Torres Sofía , López-Lucendo María , Balyasnikova Irina V. , Casal J. Ignacio
Published: April 2023

List of proteins coimmunoprecipitated with IL13Rα2
Supplementary Methods from Intracellular Osteopontin Inhibits Toll-like Receptor Signaling and Impedes Liver Carcinogenesis
Authors: Fan Xiaoyu , He Chunyan , Jing Wei , Zhou Xuyu , Chen Rui , Cao Lei , Zhu Minhui , Jia Rongjie , Wang Hao , Guo Yajun , Zhao Jian
Published: April 2023

Supplementary Methods. Description of additional methods and procedures used in the study.
Supplemental Video 2 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental Video 2: Endoscopic high-speed videos - precancerous lesions. The video shows a short sequence of the laryngeal high-speed video from each subject of the precancerous lesion group. The segmentation of the vocal folds is also shown (red: right vocal fold, blue: left vocal fold)
Supplementary Information from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: April 2023

Supplementary Methods, Figure Legends and References
Supplemental Video 1 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental Video 1: Endoscopic high-speed videos - control group. The video shows a short sequence of the laryngeal high-speed video from each subject of the control group. The segmentation of the vocal folds is also shown (red: right vocal fold, blue: left vocal fold)
Supplementary Figure S6 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: April 2023

Supplementary Figure S6. Expression and localization of wild EphA2 and uncleavable EphA2 mutant.
Supplemental PVG Figure 1 from A Noninvasive Procedure for Early-Stage Discrimination of Malignant and Precancerous Vocal Fold Lesions Based on Laryngeal Dynamics Analysis
Authors: Unger Jakob , Lohscheller Jörg , Reiter Maximilian , Eder Katharina , Betz Christian S. , Schuster Maria
Published: April 2023

Supplemental PVG Figure 1. The phonovibrogram (PVG) from each subject of the control group is shown. The PVG is explained more detailed within the manuscript.
Supplementary Figure S5 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: April 2023

Supplementary Figure S5. MT1-MMP co-localizes with EphA2-p-S897, but not EphA2-p-Y594, in carcinomas.
Supplementary Figure S3 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: April 2023

Supplementary Figure S3. Cleavage of EphA2 in vitro.
Supplementary Figure S2 from Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein
Authors: Koshikawa Naohiko , Hoshino Daisuke , Taniguchi Hiroaki , Minegishi Tomoko , Tomari Taizo , Nam Sung-Ouk , Aoki Mikiko , Sueta Takayuki , Nakagawa Takashi , Miyamoto Shingo , Nabeshima Kazuki , Weaver Alissa M. , Seiki Motoharu
Published: April 2023

Supplementary Figure S2. Schematic illustration of EphA2-mediated signals.
Supplementary Movie 1 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: April 2023

Supplementary Movie 1. Intermediate computed images: z-projection of mCherry fluorescence images (left), in-focus bright field images (center), final binarized images (right). Time is indicated at the top left. Time origin was set at the end of the centrifugation step.
Supplementary Figure S1 from Cell–Cell Adhesion and Cytoskeleton Tension Oppose Each Other in Regulating Tumor Cell Aggregation
Authors: Saias Laure , Gomes Aurélie , Cazales Martine , Ducommun Bernard , Lobjois Valérie
Published: April 2023

Supplementary Figure S1. Method for automated quantification of cell aggregation. A, schematic showing the main steps for automated detection and characterization of a cell aggregate: image acquisition, selection of the working image (projection or autofocus), image binarization and segmentation, computation of the desired data. B, cell aggregation is independent of integrin adhesion. Left, area variation measured in untreated (control) conditions (n=10) and in the presence of 0.5 mM RGD peptide (n=9). Right, bright-field images of cells cultured in a standard Petri dish and either treated with 0.5 mM RGD peptide for 2 days or not treated (control). Arrows show the points of cell membrane attachment to the substrate.
Supplementary Figure 2 from TUBB3/βIII-Tubulin Acts through the PTEN/AKT Signaling Axis to Promote Tumorigenesis and Anoikis Resistance in Non–Small Cell Lung Cancer
Authors: McCarroll Joshua A. , Gan Pei Pei , Erlich Rafael B. , Liu Marjorie , Dwarte Tanya , Sagnella Sharon S. , Akerfeldt Mia C. , Yang Lu , Parker Amelia L. , Chang Melissa H. , Shum Michael S. , Byrne Frances L. , Kavallaris Maria
Published: April 2023

Purity of nuclear and cytoplasmic fractions isolated from ÃŽÂ²III-tubulin shRNA and control shRNA NSCLC cells.
Supplementary Table S3 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Table S3. Identification of known mutations.
Supplementary Table S1 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Table S1. Model Systems used in this study.
Supplementary Table and Figure Legend from Discovery and Validation of Biomarkers That Distinguish Mucinous and Nonmucinous Pancreatic Cysts
Authors: Park Jisook , Yun Hwan Sic , Lee Kwang Hyuck , Lee Kyu Taek , Lee Jong Kyun , Lee Soo-Youn
Published: April 2023

Legend for Supplementary Figure S1 and Supplementary Tables S1-S5.
Supplementary Figure S5 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Figure S5. Reintroduction of WT BRAF in metastatic cell populations.
Supplementary Figure S2 from Metastatic Competence Can Emerge with Selection of Preexisting Oncogenic Alleles without a Need of New Mutations
Authors: Jacob Leni S. , Vanharanta Sakari , Obenauf Anna C. , Pirun Mono , Viale Agnes , Socci Nicholas D. , Massagué Joan
Published: April 2023

Supplementary Figure S2. Copy number variations.
Supplemental Figures and Tables Legend from Grade-Dependent Metabolic Reprogramming in Kidney Cancer Revealed by Combined Proteomics and Metabolomics Analysis
Authors: Wettersten Hiromi I. , Hakimi A. Ari , Morin Dexter , Bianchi Cristina , Johnstone Megan E. , Donohoe Dallas R. , Trott Josephine F. , Aboud Omran Abu , Stirdivant Steven , Neri Bruce , Wolfert Robert , Stewart Benjamin , Perego Roberto , Hsieh James J. , Weiss Robert H.
Published: April 2023

Supplemental Figures Legend
Supplemental Table S1 from Syntheses and Discovery of a Novel Class of Cinnamic Hydroxamates as Histone Deacetylase Inhibitors by Multimodality Molecular Imaging in Living Subjects
Authors: Chan C.T. , Qi J. , Smith W. , Paranol R. , Mazitschek R. , West N. , Reeves R. , Chiosis G. , Schreiber S.L. , Bradner J.E. , Paulmurugan R. , Gambhir S.S.
Published: April 2023

Supplemental Table S1. Selectivity of lead HDAC inhibitors for inhibition of HDAC1-9 activities in vitro.