bluuebunny/crossref_metadata_2025 huggingface dataset:
Beyond multidirectional memory: Opening pathways to politics and solidarity
Authors: Kékesi Zoltán , Zombory Máté
Published: June 2023

Our article responds to the ongoing crisis of memory politics that has brought the problem of de-politicization of memory studies scholarship to the forefront. This reflexivity is manifested in the demand for theories that explicitly address the problems of politics and solidarity. A representative theory in this regard is Michael Rothberg’s multidirectional memory that examines “the Holocaust in the age of decolonization” and offers a non-exclusive model of public remembering and reconciliation. While we acknowledge Rothberg’s attempt to overcome the “competition paradigm” of contemporary memory, we argue that the model of multidirectional memory as a politico-ethical framework of solidarity ultimately fails because of its underlying social ontology and presentist-ahistorical method of interpretation. We give a critical analysis of his model while applying the same historical and empirical focus. By doing so, we show that the direct theoretical link between memory and solidarity is the outcome of a de-politicization of the historical record. Ultimately, we make a case for Leftist-antifascist internationalism, a paradigm he misidentified as multidirectional Holocaust memory.
Coronavirus disease 2019 and gastrointestinal disorders in children
Authors: Röckert Tjernberg Anna , Malmborg Petter , Mårild Karl
Published: June 2023

During the past 3 years, the coronavirus disease 2019 (COVID-19) pandemic has had a great impact on people all over the world. However, it has become evident that disease manifestations and severity differ across age groups. Most children have a milder disease course than adults but possibly more pronounced gastrointestinal (GI) symptoms. Given the child’s developing immune system, the impact of COVID-19 on disease development may differ compared to adults. This study reviews the potential bi-directional relationship between COVID-19 and GI diseases in children, focusing on common pediatric conditions such as functional GI disorders (FGID), celiac disease (CeD), and inflammatory bowel disease (IBD). Children with GI diseases, in general, and CeD and IBD, in particular, do not seem to have an increased risk of severe COVID-19, including risks of hospitalization, critical care need, and death. While infections are considered candidate environmental factors in both CeD and IBD pathogenesis, and specific infectious agents are known triggers for FGID, there is still not sufficient evidence to implicate COVID-19 in the development of either of these diseases. However, given the scarcity of data and the possible latency period between environmental triggers and disease development, future investigations in this field are warranted.
Association of digital health literacy and information-seeking behaviors among physicians during COVID-19 in Ethiopia: A cross-sectional study
Authors: Assaye Bayou Tilahun , Kassa Mitiku , Belachew Muluken , Birhanu Sefefe , Worku Aynadis
Published: June 2023

Background

Universal access to health information is a requirement for all global health strategies in the era of pandemics. Getting health information from the internet is a great concern for the quality of patient healthcare. This study aimed to determine the association between digital health literacy and information-seeking behavior among physicians during COVID-19.

Methods

An institutional-based cross-sectional study was conducted from December to February 2021 with a total sample size of 423. A pretest was performed among physicians before the actual data collection. After the data collection, the data were checked, cleaned, and exported into STATA v. 14. Descriptive statistics, binary logistic regression, and multivariable logistic regression analysis were applied. Then a 95% CI and a p-value of less than 0.05 were used to declare statistical significance.

Results

The study revealed that 53.81% of physicians had high digital health literacy and 52.46% had high information-seeking behaviors. Health information-seeking behaviors were determined by digital health literacy, which was 2.25 times more likely than those who had low digital health literacy (AOR = 2.25, 95% CI: [1.11–4.57]). Health-related websites (67.5%) were the most common sources of health information, and 63.30% of physicians find digital health literacy easy or very easy to learn. However, 206 (50.92%) find it difficult or very difficult to decide if the information is reliable, verified, and up-to-date. Internet access (AOR = 1.90, 95% CI: [1.16–3.12]), frequency of searching for information (AOR = 5.35, 95% CI: [2.01–14.29]). All were discovered to be significantly associated with physicians’ health information-seeking behaviors.

Conclusions

Digital health literacy is a key to seeking health information online for appropriate decision-making. Increasing internet access, and providing ICT training, and integrate it into the health information revolution agendas, helping to disseminate health information and provide timely, reliable, and relevant news and genuine information needed for their work.
The quadripartite system of inclusive education provision in China: A qualitative synthesis of policy documents
Authors: Alduais Ahmed , Deng Meng
Published: June 2023

This study presents a comprehensive analysis of Inclusive Education in China, using a quadripartite system that synthesises the most recent policy documents concerning inclusion and segregation. The study addresses four research questions that focus on the status, merits and shortcomings of existing policies, implementation, and opportunities for improvement. The study adapts the European Agency for Special Needs and Inclusive Education (EASNIE) framework for assessing and ensuring quality inclusive education provision. Primary policy documents analysed include the National Plan 2010–2020, Compulsory Education Law of the People’s Republic of China 2010–2020, Law on the Protection of Persons with Disabilities, and Reports and documents from the China Disabled Persons’ Federation (CDPF). Tabulation and visualisation of data and findings are based on the Country Policy Review and Analysis, which includes 12 measures for assessment and implications, and the Prevent-Intervene-Compensate model provided by EASNIE. The study offers detailed findings and descriptions of inclusive education in China, highlighting both strengths and weaknesses, while providing implications and actions for improving the quality of inclusive education in the country. The study concludes that while China has unique forms of provision for inclusive education, there are still areas that require improvement to ensure better outcomes for all learners.
Association of Trochlear Length on Sagittal MRI to Trochlear Dysplasia in Knees With Patellar Instability
Authors: Tanaka Miho J. , LaPorte Zachary L. , Perry Nicholas P.J. , Velasquez Hammerle Maria V. , Nukala Varun , Liu Fang
Published: June 2023

Background:

Trochlear dysplasia is a primary risk factor for patellar instability and leads to loss of the osteochondral constraint of the patella. Trochleoplasty techniques include the Peterson grooveplasty, which alters the length of the trochlea; however, a radiographic measurement of trochlear length to support this has not been described.

Purpose:

To describe measurements to quantify trochlear length on sagittal magnetic resonance imaging in patients with and without patellar instability and to correlate trochlear length with measurements of trochlear dysplasia.

Study Design:

Cross-sectional study; Level of evidence, 3.

Methods:

A total of 66 age- and sex-matched knees (36 female and 30 male; mean age, 20.8 ± 4.8 years) were included in this study, of which 33 had patellar instability. Trochlear extension length (TEL) and trochlear alpha angle (TAA) were measured on 3 sagittal magnetic resonance imaging scans (center of the knee, center of the medial condyle, and center of the lateral condyle), and measurements were compared between symptomatic and control knees. Receiver operating characteristic curve analysis was performed, and the area under the curve (AUC) was calculated to describe the accuracy of each measurement to distinguish between knees with and without patellar instability. Linear and multivariate regression analyses were performed to assess the relationship between sagittal measurements and axial measurements of trochlear dysplasia, including lateral trochlear inclination, sulcus angle, and trochlear depth, as well as patient size reflected by the epicondylar distance.

Results:

In symptomatic knees, the central trochlea extended more proximally than in control knees, as determined by the TEL (14.0 ± 3.0 vs 11.5 ± 2.3 mm, respectively; P < .001) and TAA (68.4° ± 3.8° vs 70.5° ± 3.4°, respectively; P = .017). AUC calculations showed that a TEL ≥11 mm at the central trochlea was predictive of patellar instability in both male and female knees (AUC = 0.83 and 0.77, respectively), as was a TAA ≤67° in female knees (AUC = 0.72). An independent association between the central TEL and sulcus angle was found. The central TEL showed a weak correlation with patient size, as measured by the epicondylar distance, while the TAA did not.

Conclusion:

In knees with symptomatic patellar instability, the central trochlea was found to extend 2.5 mm more proximally than in control knees, and this increase in length correlated with severity of trochlear dysplasia. As radiographic examinations of the trochlea and grooveplasty procedures are often based on the proximal extent of the cartilaginous trochlea, further studies are needed to identify the role of trochlear length in the assessment and treatment of trochlear dysplasia in the setting of patellar instability.
Long-term Quality of Life in Patients After ACL Reconstruction With Concomitant Meniscal Injury Treatment: Patient-Reported Outcomes at Minimum 10-Year Follow-up
Authors: Chalatsis Georgios , Mitrousias Vasileios , Siouras Athanasios , Panteliadou Freideriki , Tziolas Ioannis , Solomou Chrysovalantis , Hantes Michael
Published: June 2023

Background:

Long-term studies of patients after anterior cruciate ligament (ACL) reconstruction with or without concomitant meniscal tear treatment are limited.

Purposes:

To (1) report postoperative outcomes after anatomic ACL reconstruction with a hamstring autograft, (2) investigate how concomitant treatment of meniscal injury could affect these outcomes, and (3) evaluate the association between quality of life and activity levels at a minimum 10-year follow-up.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

Patients treated with a unilateral, anatomic ACL reconstruction between 2005 and 2011 were investigated. The following patient-reported outcome measures (PROMs) were reported for the overall sample as well as a subsample of patients with meniscal injury: International Knee Documentation Committee Subjective Knee Form (IKDC-SKF), Knee injury and Osteoarthritis Outcome Score (KOOS), Lysholm knee score, Tegner activity scale, 5-level EQ-5D (EQ-5D-5L), and patient satisfaction. Sex, age, body mass index (BMI), and meniscal injury treatment (meniscectomy vs meniscal repair) were examined as patient-specific risk factors regarding long-term activity and quality of life.

Results:

Overall, 106 patients, 90 men (85%) and 16 women (15%), were enrolled in the study, with a mean follow-up of 13.2 years. The ACL retear rate was 2.8%. The mean scores were 80.6 ± 16.7 (IKDC-SKF), 87.4 ± 15.0 (KOOS), 90.5 ± 11.5 (Lysholm), 5.6 ± 1.9 (Tegner), and 91.8 ± 14.5 (EQ-5D-5L). The majority (90.6%) of patients considered their knee state satisfactory during follow-up. When compared with patients who underwent meniscal repair, patients who underwent meniscectomy had statistically significantly lower scores on all PROMs except for the Tegner and EQ-5D-5L ( P < .05 for all). The mean difference between the 2 groups was ≥7 points on all PROM scores. Patient sex, age, and BMI did not affect PROM scores. There was a statistically significant, strong positive correlation between quality of life and activity.

Conclusion:

Patients had few or no symptoms and considered their knee state satisfactory 13.2 years after anatomic ACL reconstruction. Patients with concomitant meniscal tears having undergone meniscal repair had improved PROMs compared with those treated with meniscectomy. Finally, participation in activities of daily living and sports was interrelated with quality of life and was not affected by patient age, sex, or BMI.
Struck by stroke - experiences of living with stroke in a rural area in Uganda
Authors: Timm Linda , Kamwesiga Julius , Kigozi Sulaiman , Ytterberg Charlotte , Eriksson Gunilla , Guidetti Susanne
Published: June 2023

Background

The global burden of stroke is increasing and persons with low socioeconomic status are among those worst affected. In Uganda, stroke is estimated to be the sixth highest ranking cause of death. The Ugandan healthcare system is reported to be inequitable, where poorer populations often live in rural areas with long distances to health care. Stroke rehabilitation is often scarce, with less financial and human resources. The aim of this study was to explore and describe the consequences of stroke in daily activities in everyday life for people in a rural part of Masaka in Uganda.

Methods

Qualitative study design. Fourteen persons who had had stroke and were living in their home environment were interviewed about their experiences of having a stroke and managing their lives after the stroke incident. The interviews were analysed using thematic analysis. In addition, sociodemographic data and level of independence (Barthel Index and Stroke Impact Scale 3.0) was collected to describe participant characteristics.

Results

Most of the participants had major consequences of stroke and described that they were dependent on support for managing their daily activities. Five themes were identified in the analysis: (1) Accepting and adapting to new ways of managing everyday life, (2) Changing roles and hierarchical positions, (3) Depending on caregiver support, (4) Interrupted care due to economic constraints, (5) Stroke leading to losses and losses leading to stroke.

Conclusions

The consequences of stroke on the persons’ daily lives clearly reached beyond the person with stroke, affecting the whole family and their proximate social networks. These consequences included increased burdens on caregivers and a worsened economic situation for all persons affected. Therefore, interventions for stroke management should preferably not only target the individual affected by stroke, but also support the caregivers in the caring and rehabilitation process. Home rehabilitation approaches with a focus on improving health literacy are suggested.
Slack in the infrastructure of intensive care units: resilience management in the post-pandemic era
Authors: Marczyk Carlos Emilio Stigler , Saurin Tarcisio Abreu , Bulhões Iamara Rossi , Patriarca Riccardo , Bilotta Federico
Published: June 2023

Background

Although slack is an asset to resilient hospitals, it is usually explicitly discussed only in terms of the quantity and quality of beds and staff. This paper expands this view by addressing slack in four infrastructures of intensive care units (ICUs) (physical space, electricity supply, oxygen supply, and air treatment) during the COVID pandemic.

Methods

The study occurred in a leading private hospital in Brazil, aiming at the identification of slack in four units originally designed as ICUs and two units adapted as ICUs. Data collection was based on 12 interviews with healthcare professionals, documents, and comparison between infrastructures and regulatory requirements.

Results

Twenty-seven instantiations of slack were identified, with several indications that the adapted ICUs did not provide infrastructure conditions as good as the designed ones. Findings gave rise to five propositions addressing: relationships intra and inter infrastructures; the need for adapted ICUs that match as closely as possible the designed ICUs; the consideration of both clinical and engineering perspectives in design; and the need for the revision of some requirements of the Brazilian regulations.

Conclusions

Results are relevant to both the designers of the infrastructures and to the designers of clinical activities as these must take place in fit-for-purpose workspaces. Top management might also benefit as they are the ultimate responsible for decision-making on whether or not to invest in slack. The pandemic dramatically demonstrated the value of investing in slack resources, creating momentum for this discussion in health services.
Clinical significance of immunohistochemical expression of DDR1 and β-catenin in colorectal carcinoma
Authors: Dawoud Marwa Mohammed , Salah Marwa , Mohamed Asmaa Shams El Dein
Published: June 2023

Background

Despite recent advances in therapy modalities of colorectal cancer (CRC), it is still the third cause of cancer-related deaths worldwide. Thus, the search for new target therapies became mandatory. DDR1 is a collagen receptor that has a suggested role in cellular proliferation, tumor invasion, and metastasis.

Material and methods

Forty-eight cases of CRC, 20 of CR adenoma, and 8 cases of non-tumoral colonic tissue were subjected to immunohistochemistry by DDR1 and β-catenin antibodies. Results were compared among the different studied groups and correlated with clinicopathologic data and available survival data. Also, the expression of both proteins was compared versus each other. Results were compared among the 3 studied groups and correlated with clinicopathologic and survival data.

Results

It revealed a stepwise increase of DDR1 expression among studied groups toward carcinoma (P = 0.006). DDR1 expression showed a direct association with stage D in the modified Dukes’ staging system (P = 0.013), higher-grade histologic types (P = 0.008), and lymph node invasion (P = 0.028) but inverse correlation with the presence of intratumoral inflammatory response (TIR) (P = 0.001). The shortest OS was associated with strong intensity of DDR1 (P = 0.012). The DDR1 and β-catenin expressions were significantly correlated (P = 0.028), and the combined expression of both was correlated with TNM staging (P = 0.017).

Conclusion

DDR1 overexpression is a frequent feature in CRC and CR adenoma. DDR1 is a poor prognostic factor and a suppressor of the TIR. DDR1 and β-catenin seem to have a synergistic action.
Individualized 3D-printed navigation template-assisted tension band wiring for olecranon fractures
Authors: Xiong Xu , Chen Ya-Ling , Zhao Lan , Li Hao , Xu Min , Shuang Feng
Published: June 2023

Purpose

3D printing techniques guide precision medicine and show great development potential in clinical applications. The purpose of this study was to compare the clinical outcomes of 3D-printed navigation templates versus free-hand in tension band wiring (TBW) procedures for olecranon fractures.

Methods

Patients who underwent TBW due to Mayo type II olecranon fractures between January 2019 and December 2021 in our hospital were prospectively enrolled in the study. The patients were divided into the 3D printed navigation template guiding TBW group (3D printed group) and the free-hand TBW group (free-hand group). The primary endpoint of this study was the success rate of the bicortical placement of Kirschner wires (K-wires). Times of intraoperative fluoroscopy, operation times, complications, VAS scores, and Mayo Elbow Performance Scores (MEPS) were analyzed as the secondary outcomes measure.

Results

The success rate of the bicortical placement of K-wires was 85.7% in the 3D Printed group was significantly higher than the free-hand group (60%). There were fewer times of intraoperative fluoroscopy in the 3D Printed group (1.43 ± 0.51) than that in the free-hand group (2.60 ± 1.00) with statistical significance (P < 0.05). At the date of the last follow-up, four patients suffer from pain and skin injury at the K-wires insertion site in the 3D Printed group and 14 patients in the free-hand group, a significant difference between the two groups (P < 0.05). No statistically significant differences were found in operation time, VAS scores, and MEPS between the two groups.

Conclusions

The individualized 3D-printed navigation template-assisted TBW demonstrated good accuracy and resulted in reduced times of intraoperative fluoroscopy and complication compared to the free-hand TBW for olecranon fractures.
Effectiveness of a theory-based educational intervention on work-related musculoskeletal disorders preventive behaviors among assembly-line female workers: a study protocol for a randomized controlled trial
Authors: Hosseini Zakieh Sadat , Tavafian Sedigheh Sadat , Ahmadi Omran , Maghbouli Reza
Published: June 2023

Background

The use of preventive behaviors of musculoskeletal disorders (MSDs) requires proper training, which leads to correct decisions regarding maintaining postures at work and performing stretching exercises. Due to very repetitive work, applying manual force, improper postures, and static contractions of proximal muscles, assembly-line female workers suffer from musculoskeletal pains. It is assumed that structured and theory-based educational intervention using a learning-by-doing (LBD) approach may increase the preventive behaviors against MSDs and reduce the consequences of these disorders.

Methods

This randomized controlled trial (RCT) will be conducted in three phases: phase 1: validation of the compiled questionnaire, phase 2: determining the social cognitive theory (SCT) constructs that predict the preventive behaviors of MSDs in assembly-line female workers, and phase 3: designing and implementing the educational theory. The educational intervention is based on the LBD approach, and the study population includes assembly-line female workers in electronic industries of Iran, who are randomly divided into two intervention and control groups. The intervention group received the educational intervention in the workplace and the control group does not receive any intervention. The theory-based educational intervention includes evidence-based information along with pictures, fact sheets, and published literature about a good posture at work and the need to perform proper stretching exercises. The educational intervention aims to improve the knowledge, skills, self-efficacy, and intention of assembly-line female workers to adopt preventive behaviors of MSDs.

Discussion

The present study will evaluate the effects of maintaining a good posture at work and performing stretching exercises on the adherence to preventive behaviors of MSDs among assembly-line female workers. The developed intervention is easily implemented and evaluated in a short period of time based on the improved score of the rapid upper limb assessment (RULA) method and the mean score of adherence to stretching exercises and can be provided by a health, safety, and environment (HSE) expert.

Trial registration

ClinicalTrials.gov IRCT20220825055792N1. Registered on 23 September 2022 with the IRCTID.
Late-stage diagnosis of carcinoid heart disease due to lack of access to health care
Authors: Sharma Aditi , Fierro Maria E. , Pak Stella , Thallapureddy Keerthi , Awobajo Moyosore , Hui Dawn , Otchere Prince
Published: June 2023

Carcinoid syndrome (CS) is a unique constellation of symptoms caused by release of vasoactive substances from neuroendocrine tumors (Pandit et al., StatPearls, 2022). Neuroendocrine tumors are rare with an annual incidence of 2 in 100,000 people (Ram et al., 46:21-27, 2019). Up to 50% of patients with these tumors will develop carcinoid syndrome, which is characterized by symptoms caused by elevated levels of serotonin and most commonly include fatigue, flushing, wheezing, and non-specific gastrointestinal symptoms such as diarrhea and malabsorption (Pandit et al., StatPearls, 2022) (Fox et.al., 90:1224-1228, 2004). Over time, patients with carcinoid syndrome can develop carcinoid heart disease (CHD). CHD refers to the cardiac complications that occur when the vasoactive substances, such as serotonin, tachykinins, and prostaglandins, secreted from the carcinoid tumors. These complications most commonly include valvular abnormalities, but can also present as coronary artery damage, arrhythmias or direct myocardial injury (Ram et al., 46:21-27, 2019). While CHD is not typically an initial feature of carcinoid syndrome, it does eventually occur in up to 70% of patients with carcinoid tumors (Ram et al., 46:21-27, 2019) (Jin et.al., 146:65-73, 2021) (Macfie et.al., 224:665-669, 2022). CHD is associated with significant morbidity and mortality due to the risk of progressive heart failure (Bober et.al., 14:1179546820968101, 2020). In this case, we describe a 35-year-old Hispanic woman in South Texas with undiagnosed carcinoid syndrome for over 10 years that eventually progressed to severe CHD. In this patient’s case, we emphasize how lack of access to healthcare resulted in delay of diagnosis, appropriate treatment, and worsened prognosis in this young patient.
Consent in minors: the differential treatment of acceptance and refusal. Part 2 Minors’ decision-making and the reach of their capacity
Authors: Hawkins Tim , Curtice Martin
Published: June 2023

This is the second of a pair of articles reviewing the topic of consent in minors. Both articles have a particular emphasis, drawing on theory and case law, on the differential treatment of acceptance and refusal in minors. This article considers the concept of capacity in young people (aged 16 and over) and competence in children (under the age of 16) by reviewing underpinning statute and case law with particular reference to England and Wales. This provides a platform for consideration of the reach of capacity in minors with regard to acceptance and refusal of treatment. In doing so the article explores the key, but still elusive, ingredient of maturity, which has significance to the process. Fictitious vignettes allow consideration of the application of the concepts of maturity and autonomy in clinical practice. The article also considers the potential for the UK's Parliament to make changes to current statute regarding consent in minors.
Consent in minors: the differential treatment of acceptance and refusal. Part 1 Autonomy and children's rights
Authors: Hawkins Tim , Curtice Martin , Adams Tom
Published: June 2023

This is the first of two articles reviewing consent in those under the age of 18 (also referred to as ‘minors’ in UK law). This can be a complex issue in clinical practice because the law endows competent/capacitated minors with the absolute right to accept treatment, but a limited right to refuse. This first article summarises recent cases of refusal of treatment in minors. It uses them to ask two central questions: how do we, as clinicians, think about autonomous self-determination in minors and to what extent does the rights agenda support minors’ autonomous self-determination? Autonomy as one of the principles of biomedical ethics is explored. How the minors’ rights agenda supports the development of autonomy is considered. The amount of weight given in the domestic courts to the rights of minors with reference to the Human Rights Act 1998 and the United Nations Convention on the Rights of the Child is described. These considerations demonstrate the way that the courts are giving the views of the minor greater weight in decision-making in keeping with age and maturity. This article introduces the second article, which comprehensively reviews decision-making in minors, explores competence and capacity in minors and examines the differential treatment of acceptance and refusal.
Managing self-harm in young people presenting to the emergency department and challenges in navigating the national guidelines
Authors: Pereira Carvalho Naashoma , Pierson Kim , Shaker-Naeeni Hadi , Sabel Esther
Published: June 2023

Suicide is the most common cause of death for young people in the UK and around 50% of completed suicides in young people have previous self-harm as a theme. Hence, robust management of young people presenting with self-harm to the emergency department is crucial. Guidelines published by the National Institute for Health and Care Excellence (NICE) and the Royal College of Psychiatrists advise an overnight admission for under-16s with self-harm, which is a challenge during winter pressures or bed shortages. In this editorial we discuss the difficulties faced when navigating NICE 2004 guidance documents with the realities of the coalface and consider the prospects for current practice and the future with the NICE 2022 guidance.
Biculturalism and Historiography in the Era of Neoliberalism: A View from Aotearoa New Zealand
Authors: Johnson Miranda
Published: June 2023

The making of the bicultural state of Aotearoa New Zealand is the product of a distinctive postcolonial and neoliberal late twentieth-century history. In this context, a predominantly anglophone settler state finally responded to decades-long claims about Indigenous dispossession by creating the Treaty of Waitangi Tribunal in 1975, an institution that a decade later took a wide-ranging approach to the investigation of historical grievances. The tribunal produced an alternative historiography that imagined a partnership between Māori and the Crown, not only in the service of evaluating past actions but also with the aim of creating better relations for the future. This article offers a brief account of biculturalism and “treaty partnership” in three overlapping modes: as an emergent and then hegemonic political discourse; as generating a new historiography; and in terms of the reframing and bureaucratization of research practices in Aotearoa New Zealand. In this milieu, research ethics is not simply a matter of interpersonal politics but, in fact, has become a matter of governmentality—that is, of regulating the conduct of researchers as subjects of particular forms of state power.
Flamboyant
Authors: Frank Chandra
Published: June 2023

This essay draws on the feminist and queer organization Flamboyant, the first and only nationwide Black and migrant women–run meeting place, active in the 1980s in Amsterdam, the Netherlands. After five years, the collective was forced to leave their space due to a lack of funding and burnout. The organization was named after the tropical flamboyant tree (Delonix regia), which according to the founders “has not been tamed and would prefer to die instead of shrinking in the Dutch living room.” I argue that this metaphorical mission statement is an articulation of wildness that rejects Dutch colonial expectations of integration and order. Flamboyant’s refusal to be tamed eventually led to the demise of the only archive run by Black women and women of color. This essay firmly situates Flamboyant within a Black and women of color (WOC) European scholarly and activist experience. Drawing on archival materials and geographical reflections of place, I demonstrate how the loss of Dutch feminist and queer of color spaces and archives are embedded within transnational feminist genealogies of mourning.
“Out in the Streets”
Authors: Koutsougera Natalia A.
Published: June 2023

This article provides a socio-anthropological portrayal of the hip-hop narrational mosaics in Greece through the intertemporal exploration of two hip-hop scenes: the rap scene and the hip-hop dance scene. It explores the gray and contested zones of a local hip-hop culture—which reflect on global hip-hop imageries, norms, and antinomies–through permutations and manifestations of difference, hybridization and subcultural capital, and their subversive intersections with race, class, gender, and affective states in contemporary Greece in landscapes of crisis. Drawing on content analysis of rap lyrics and ethnographic fieldwork on rap and hip-hop dance performativities, resonating contemporary Greek society’s precarities, traumas, and ethics, this article explains why hip-hop and street cultures are so popular today in Greece. Furthermore, it highlights their global dynamics and their present and future potential as an empowering and emancipatory space for young generations.
The actin-myosin cytoskeleton mediates reversible agonist-induced membrane blebbing
Authors: Torgerson Rochelle R. , McNiven Mark A.
Published: June 2023

Suprastimulation of pancreatic acinar cells with specific agonists inhibits zymogen secretion and induces the formation of large basolateral blebs. Currently the molecular mechanisms that mediate this dramatic morphologic response are undefined. Further, it is unclear if blebbing represents a terminal or reversible event. Using computer-enhanced video microscopy of living acini we have found that these large blebs form rapidly (within 2-3 minutes) and exhibit ameboid undulations. They are induced by small increases in agonist concentration and require an energy-dependent phosphorylation event. Remarkably, the blebs are rapidly absorbed when agonist levels are reduced, indicating that blebbing is a reversible response to a physiological stimulus, not a terminal event. Morphological methods show that these dramatic changes in cell shape are accompanied by a marked reorganization of actin and myosin II at the basolateral domain. During 30 minutes of suprastimulation, both basolateral actin and myosin II gradually increase to form a ring centered at the necks of the blebs. Immunocytochemical and biochemical studies with a phospho-specific antibody to the myosin regulatory light chain reveal an activation of myosin II in suprastimulated acini that is completely absent in resting cells. Studies using cytoskeletal antagonistic drugs indicate that bleb formation and motility require actin remodeling concomitant with an activation of myosin II. This aberrant activation and reorganization of the actin-myosin cytoskeleton is likely to have detrimental effects on acinar cell function. Additionally, this mechanism of bleb formation may be conserved among other forms of physiological blebbing events.
High levels of actin tyrosine phosphorylation: Correlation with the dormant state of Dictyostelium spores
Authors: Kishi Yoshiro , Clements Chris , Mahadeo Dana C. , Cotter David A. , Sameshima Masazumi
Published: June 2023

Upon removal of nutrients, the amoebae of the cellular slime mold Dictyostelium discoideum differentiate into dormant spores which survive starvation stress. In this study, we demonstrate that half of the actin molecules in the spores are tyrosine-phosphorylated. The phosphorylated actin is distributed around immobile crenate mitochondria and vesicles, as well as in the cytoplasm of the spores. The actin isolated from spore lysates contains phosphorylated and unphosphorylated forms at the same molar ratio as that of the original whole spore lysate. Under actin polymerizing conditions they form actin filaments and then they are completely depolymerized under actin depolymerizing conditions, indicating that tyrosine phosphorylation of actin may not prohibit actin polymerization nor stimulate depolymerization. The phosphorylation levels increase at the end of the culmination stage when spores have matured morphologically and physiologically, and reach maximum levels after an additional 12 hours of development. The levels are stable for 20 days following spore maturation, and decline to undetectable levels within the next 10 days.

Spores having high levels of phosphorylation show high viability, and vice versa. Following activation of spores with nutrient medium containing spore germination promoters, the phosphorylation levels quickly decrease with a half-life of about 5 minutes. After 20 minutes spores begin to swell. At this later time, most of the phosphorylated actin already has been dephosphorylated. Also, in heat-activated spores actin dephosphorylation occurs prior to spore swelling. However, addition of phosphatase inhibitors following heat-activation, prevented spore swelling and dephosphorylation of actin. Our data indicate that the high levels of actin tyrosine phosphorylation, specific to the spore stage, may be required for maintaining dormancy to withstand starvation stress. The rapid dephosphorylation of actin leads to a reactivated dynamic actin system which participates in spore swelling, vesicle movement, and mitochondrial shape changes during the spore germination process.
Common and variant properties of intermediate filament proteins from lower chordates and vertebrates; two proteins from the tunicate Styela and the identification of a type III homologue
Authors: Riemer Dieter , Weber Klaus
Published: June 2023

The chordates combine the vertebrates and the invertebrate phyla of the cephalo- and urochordates (tunicates). Two cytoplasmic intermediate filament (IF) proteins of the urochordate Styela plicata are characterized by cDNA cloning, gene organization, tissue specific expression patterns in the adult animal and the self assembly properties of the recombinant proteins. In line with metazoan phylogeny St-A and St-B have the short length version of the coil 1b domain found in all vertebrate and cephalochordate IF proteins while protostomic IF proteins have the longer length version with an extra 42 residues. St-A is the first IF protein from a lower chordate which can be unambiguously related to a particular vertebrate IF subfamily. St-A shares 46% sequence identity with desmin, displays the N-terminal motif necessary for filament assembly of type III proteins and forms normal homopolymeric 10 nm filaments in vitro. St-A but not St-B is present in smooth muscle cells of the body wall musculature. St-A and St-B are found as separate networks in some interior epithelia. St-B shares 30 to 35% identity with keratin 8, St-A and desmin and does not form IF under in vitro assembly conditions. Its relation to a particular vertebrate IF type or to the eight currently known IF proteins from the cephalochordate Branchiostoma remains unresolved. The striking relation between St-A and desmin predicts that the common progenitor of the urochordate (tunicate) and the cephalochordate/vertebrate lineages already possessed a type III homologue. Unlike in vertebrates intron patterns cannot be used to classify the tunicate IF genes. Although St-A is a type III homologue its gene shows an intron position which in vertebrates is restricted to keratin type II genes.
Regulation of mammalian replication origin usage in Xenopus egg extract
Authors: Dimitrova Daniela S. , Gilbert David M.
Published: June 2023

Xenopus embryos initiate replication at random closely spaced sites until a certain concentration of nuclei is achieved within the embryo, after which fewer, more specific chromosomal sites are utilized as origins. We have examined the relationship between nucleo-cytosolic ratio and origin specification when Chinese hamster ovary (CHO) cell nuclei are introduced into Xenopus egg extracts. At concentrations of intact late-G1-phase nuclei that approximate early Xenopus embryos, the entire genome was duplicated nearly 4 times faster than in culture, accompanied by a de-localization of initiation sites at the dihydrofolate reductase (DHFR) locus. As the concentration of nuclei was increased, the number of initiation sites per nucleus decreased and initiation at the DHFR locus became localized to the physiologically utilized DHFR origin. Origin specification was optimal at nuclear concentrations that approximate the Xenopus mid-blastula transition (MBT). Higher concentrations resulted in an overall inhibition of DNA synthesis. By contrast, with intact early G1-phase nuclei, replication initiated at apparently random sites at all concentrations, despite an identical relationship between nucleo-cytosolic ratio and replicon size. Furthermore, permeabilization of late-G1-phase nuclei, using newly defined conditions that preserve the overall rate of replication, eliminated site-specificity, even at nuclear concentrations optimal for DHFR origin recognition. These data show that both nucleo-cytosolic ratio and nuclear structure play important but independent roles in the regulation of replication origin usage. Nucleo-cytosolic ratio clearly influences the number of replication origins selected. However, titration of cytosolic factors is not sufficient to focus initiation to specific sites. An independent mechanism, effecting changes within G1-phase nuclei, dictates which of many potential initiation sites will function as an origin.
Developmental association of the β-galactoside-binding protein galectin-1 with the nuclear matrix of rat calvarial osteoblasts
Authors: Choi Je-Yong , van Wijnen André J. , Aslam Fauzia , Leszyk John D. , Stein Janet L. , Stein Gary S. , Lian Jane B. , Penman Sheldon
Published: June 2023

The protein composition of the nuclear matrix changes significantly as the osteoblast matures from a proliferating pre-osteoblast to an osteocyte embedded in a mineralized matrix. These matrix protein are the result of developmental stage-specific gene expression during osteoblast differentiation. To isolate nuclear matrix proteins unique to the bone phenotype we analyzed nuclear matrix preparations from cultures of rat calvarial osteoblasts by high resolution two-dimensional gel electrophoresis at two different stages: proliferation (day 3) and differentiation (day 18, mineralized). We characterized one protein (14 kDa; pI 5.0), that was detectable only in the nuclear matrix of differentiated osteoblasts. By mass spectrometry and microsequencing, this protein was identified as the β-galactoside-binding protein galectin-1. Both immunofluorescence staining of nuclear matrix preparations with the galectin-1 antibody and western blot analysis of subcellular fractions confirmed that galectin-1 is only associated with the nuclear matrix in differentiated osteoblasts as the result of differential retention. Galectin-1 protein and mRNA are present throughout osteoblast differentiation. Galectin-1 is present in the cytoplasmic and nuclear fractions in both proliferating and differentiated osteoblasts. However, its only stable binding is to the nuclear matrix of the differentiated osteoblast; but, in proliferating osteoblasts, galectin-1 is not retained in the nuclear matrix. Taken together, our results suggest that developmental association of galectin-1 with the nuclear matrix reflects differential subnuclear binding of galectin-1 during osteoblast differentiation.
A World Trading System for the Twenty-First Century
Authors: Beshkar Mostafa
Published: June 2023

Mostafa Beshkar of Indiana University-Bloomington reviews “A World Trading System for the Twenty-First Century” by Robert W. Staiger. The Econlit abstract of this book begins: “Discusses the success of the General Agreement on Tariffs and Trade (GATT) and its ideal economic environment, evaluating whether twenty-first-century changes in the global economy imply the need for changes in the design of the World Trade Organization (WTO) system.”
The Consumption of Advertising in the Digital Age: Attention and Ad Content
Authors: Dukes Anthony , Liu Qihong
Published: June 2023

This article studies the consumption of advertising when attention is costly. Our objective is to understand the advertiser’s optimal decision for informational and noninformational content when facing consumers with heavy distractions common in the digital age. We take an equilibrium approach in which an ad is consumed if and only if the content of the ad is worth the viewer’s attention. We classify many advertising decisions observed in practice. First, an advertiser can structure content to induce curiosity for continued viewing by showing the information that is relatively less likely to resonate with the broad audience. This tactic is evident in clickbait ads and “mystery ads.” Second, we find that digital ads, which tend to be skippable, have lower amounts of noninformational content (e.g., entertainment) relative to nonskippable ads. This finding can explain the industry perception that ads on digital media are of lower copy quality than traditional ads.

This paper was accepted by Dmitri Kuksov, marketing.

Funding: This work was supported by the Marketing Science Institute [Grant 4000790].

Supplemental Material: The online appendix is available at https://doi.org/10.1287/mnsc.2023.4793 .
Prevalência e severidade de sintomas em mulheres na menopausa: um estudo descritivo
Authors: Santos Adrielle De Souza , Moreira Amanda Brito , Souza Marcio Leandro Ribeiro de
Published: June 2023

Introdução: Muitas mulheres sofrem com sintomas associados à menopausa, que podem apresentar diferentes graus de intensidade e afetar sua qualidade de vida. Objetivo: Identificar a prevalência e severidade dos principais sintomas nas diferentes fases do climatério. Métodos: Foram selecionadas mulheres com idades entre 40 e 65 anos, que responderam a um questionário on-line com dados sociodemográficos, de saúde, alimentação e características menstruais e de menopausa. Para avaliar os sintomas da menopausa e sua intensidade, foi aplicado o questionário internacional validado Menopause Rating Scale (MRS). Resultados: Foram incluídas 283 mulheres (36,8% na pré-menopausa, 24% na perimenopausa e 39,2% na pós-menopausa). Excesso de peso foi mais prevalente na perimenopausa do que na pré-menopausa (P=0,012). Sintomas como diminuição da libido, secura vaginal, incontinência urinária, dores musculares e articulares, alterações lipídicas e ondas de calor, calorões, foram mais prevalentes em valores absolutos nas mulheres pós-menopausa. As mulheres no período de perimenopausa apresentaram maior prevalência, em valores absolutos, de estresse, irritabilidade, dor de cabeça, problemas na pele, falta de concentração/memória, distúrbios do sono e fadiga. De acordo com o MRS, não houve diferença no domínio psicossocial (P=0,265) e os sintomas somato-vegetativos e urogenitais são mais intensos nas mulheres na perimenopausa e pós-menopausa, quando comparadas com as mulheres na pré-menopausa (P<0,001). O escore global do questionário também demonstra essa intensidade menor no grupo pré-menopausa (P=0,001). Conclusões: Este estudo demonstrou uma prevalência e severidade maior de sintomas em mulheres na perimenopausa e pós-menopausa, o que pode prejudicar a qualidade de vida dessas mulheres nessa fase da vida.
Interaksi Siswa PAUD/TK As-Sholihin Surabaya dengan Gadget dan Perilaku Pendampingan oleh Orang Tua
Authors: Handayani Puji , Surjani Titiek , Rahayu Sri , Kuswidiastuti Devy , Puspito Wulandari Diah , Juniastuti Susi
Published: June 2023

Perkembangan internet sedemikian masif dan merasuk di berbagai lapisan masyarakat. Kemudahan akses aneka rupa aplikasi bisa dilakukan oleh siapapun lewat perangkat HP (gadget), tidak terkecuali bagi anak-anak. Kebanyakan balitamaupun batita tidak asing lagi dengan perangkat gadget bahkan cukup piawai memainkannya, entah untuk kebutuhan bermain, sarana hiburan dsb. Kondisi pandemi covid-19 secara nyata turut mendongkrak penggunaan gadget bagi anak-anak, baik untuk kelancaran proses kegiatan belajar yang bersifat daring (online), pengerjaan tugas, dll. Keberadaan gadget tentu sangat membantu dalam menggantikan aktifitas sehari-hari yang biasanya dilakukan secara tatap muka (luring), namun tetap menyimpan potensi negatif jika penggunaannya tidak diawasi dan dibatasi. Dampak buruk ini rentan menimpa pada anak usia pra-sekolah atau anak berpendidikan PAUD/TK, mengingat kepahaman mereka terhadap literasi digital masih minim bahkan belum ada. Kegiatan pengabdian masyarakat (Abmas) dengan sasaran orang tua (wali siswa) di PAUD/TK As-Sholihin RT01/RW01 Kelurahan Keputih, Kecamatan Sukolilo, Surabaya ini mencoba memotret kebiasaan sehari-hari anak dalam berinteraksi dengan gadget serta model pendampingan orang tua (wali siswa)dalam mengawasinya. Rangkaian kegiatan terdiri dari survei kondisi sehari-hari penggunaan gadget pada anak dan perilaku pendampingan orang tua, penyuluhan resiko-resiko penggunaan gadget pada anak, penyuluhan bentuk-bentuk bahaya internet, konsultasi dan tanya-jawab, serta praktek pengaturan gadget agar aman dan ramah untuk anak.