bluuebunny/crossref_metadata_2025 huggingface dataset:
The study of the mortality characteristics of SARS-CoV-2 in the territory of the Russian Federation in 2020–2023 using the secondorder phase transition model
Authors: Yuminova N. V. , Kontarov N. A. , Dolgova E. I.
Published: January 2025

Coronovirus SARS­CoV­2 has become a serious test for the entire global community in 2020. Its appearance and high speed of spread forced the heathcare system to reorient itself. In our work we focused on studying the mortality data from COVID­19 in Russia in 2020­2023. The exponential mortality increase is considered from the point of view of a secondorder phase transition. Also, using the Hurst method, we searched for the presence of a trend in mortality rate from year to year. Additional criteria are proposed in making decisions on the introduction and removal of restrictive measures. The obtained results should help in solving epidemiological problems when faced with a new infectious agent.
Possibilities of rational application of bacteriophages in the therapy of infections caused by polyresistant strains of Klebsiella pneumoniae
Authors: Gumbatova L. A. , Lebedeva E. V. , Sergeeva T. A. , Aslanov B. I. , Gordeeva S. A. , Gusev D. A.
Published: January 2025

The issue of combating antimicrobial resistance has been relevant for several decades, since the arsenal of effective antibiotics used in infectious diseases is significantly reduced, and the development of new antibacterial drugs is significantly difficult and expensive. At the same time, the possibility of widespread use of bacteriophages in hospital settings is being discussed.

Goal. Evaluation of the sensitivity to bacteriophages of hospital strains of K.pneumoniae isolated from patients in the departments of surgery and intensive care and intensive care of the Structure Clinical Infectious Disease Hospital named after S.P.Botkin.

Materials and methods. The activity of bacteriophage preparations “Sextafag” (series p158, p220, p242), “Klebsiell polyvalent bacteriophage” (series y04, y07, y10, y16), “Polyvalent Pyobacteriophage purified” (series y10, y291022) (Manufacturer: NPO Microgen JSC, Moscow) was determined by preparing suspensions of microorganisms, their sowing on nutrient media with subsequent application of bacteriophages, taking into account and interpreting the results.

Results. The majority of polyresistant K.pneumoniae strains showed sensitivity to the presented bacteriophage preparations, which allows them to be considered as additional antibacterial agents for the treatment of these groups of patients.

Conclusion. The presented results of the study showed that hospital polyand pan­resistant strains of K.pneumoniae are sensitive to preparations of monoand polyvalent bacteriophages, which can be considered as a potential alternative in conditions of antibiotic resistance. The study did not reveal a link between the antibiotic resistance profile of the culture and sensitivity to bacteriophages.
Dynamics of quantum correlations in a two-parameter class system under quantum noise
Authors: Khalil Eied , Al-Awfi Saud
Published: January 2025

In this paper, we investigate the time evolution of quantum correlations in a
two-qubit system influenced by an optical channel. The system?s dynamics are
analyzed in terms of concurrence (CN), Bell non-locality (BN), and trace
distance discord (TDD), which quantify entanglement, non-local correlations,
and quantum discord, respectively. Our model explores the impact of key
parameters such as the beam-splitter angle, ?, channel parameter, ?, and
angular frequency, ?, on these quantum correlations. The results show that
CN and BN exhibit oscillatory behavior with periodic revivals, but tend to
decay more rapidly under noisy conditions. Conversely, TDD demonstrates
greater robustness, persisting even when CN and BN collapse, indicating the
survival of quantum correlations in separable states. Higher noise strength
and angular frequencies induce faster oscillations and revivals across all
measures, with systems prepared with stronger initial quantum correlations
showing increased resilience. This study highlights the robustness of
quantum discord in noisy environments and its potential role in quantum
information processing, even in the absence of entanglement.
Innovative mathematical modelling approaches to diagnose chronic neurological disorders with deep learning
Authors: Karim Faten , Ghorashi Sara , Ishak Anis , Elhag Azhari , Mohamed Nahla
Published: January 2025

Multiple sclerosis impacts the central nervous system, causing symptoms like
fatigue, pain, and motor impairments. Diagnosing multiple sclerosis often
requires complex tests, and MRI analysis is critical for accuracy. Machine
learning has emerged as a key tool in neurological disease diagnosis. This
paper introduces the multiple sclerosis diagnosis network (MSDNet), a
stacked ensemble of deep learning classifiers for multiple sclerosis
detection. The MSDNet uses min-max normalization, the artificial hummingbird
algorithm for feature selection, and a combination of LSTM, DNN, and CNN
models. Hyperparameters are optimized using the enhanced walrus optimization
algorithm. Experimental results show MSDNet's superior performance compared
to recent methods.
Statistical properties and applications for exponentiated exponential Rayleigh distribution
Authors: Darwish Ahmed
Published: January 2025

Modelling in lifetime phenomena is a significant issue in many scientific
areas. Sometimes many standard models lack superiority in modelling data
set. Designing a new form of probability distribution by using different
techniques has received a widely attention in statistical theory in the
recent years. In this paper, we formulated exponentiated exponential
Rayleigh (EER) distribution. We discussed the reliability and hazard rate
functions of the EER distribution and computed the quantile, median,
skewness and kurtosis. Moreover, the correlations between the parameters and
the median, skewness, and kurtosis are investigated. Bayesian and
non-Bayesian approaches are adopted to estimate the unknown parameters of
EER distribution. In Bayesian approach, we are used Markov Chen Monte Carlo
(MCMC) method to obtain the approximate Bayes point estimate. The proposed
distribution is used to analyze, light-emitting diodes data, strength of
glass fibers data and Wheaton River data. The estimation results of the EER
distribution are compared with exponential Rayleigh, Rayleigh, and
exponential distributions.
Diseño de una Red Multi-Eslabón, Multi-Producto y Multi-Cliente de una Empresa Fabricadora y Comercializadora de Leche
Authors: Pantoja Diaz Jonny Jair , Colonias Murillas Said Adolfo , Henao Ordoñez Frank Yinner
Published: January 2025

El artículo describe un estudio sobre la optimización de una red Multi-Eslabón, Multi-Producto y Multi-Cliente de una empresa fabricadora y comercializadora de leche en Colombia, mediante la propuesta de un modelo matemático. Se divide en tres fases: definición de objetivos y recolección de datos, modelado matemático en AMPL y resolución del modelo. Los resultados muestran la configuración óptima de la red de distribución, identificando centros de acopio y distribución y analizando el cumplimiento de la demanda de los clientes. El modelo proporciona una solución clara y eficaz para mejorar la eficiencia operativa y la competitividad de la empresa.
Poetry as a continuous struggle between joy and hopelessness: On the Spanish and Galician translations of Adam Zagajewski’s selected poems
Authors: Jackiewicz Aleksandra
Published: January 2025

El objetivo del artículo es reflexionar sobre el papel de la creatividad en la traducción de la poesía de Adam Zagajewski. Pretendemos realizar un análisis contrastivo entre dos poemas originales («Walizka» and «Ziemia») y sus traducciones al español y al gallego –de Xavier Farré y Bartosz Dondelewski y Lidia López Teixeiro, respectivamente– para determinar si la interpretación estimula el pensamiento creativo en los traductores, y si el impacto de la poesía en la creatividad varía según la obra que leemos y luego sometemos a negociaciones lingüísticas y estéticas. Debido al idioma del artículo, también utilizamos para nuestro estudio las traducciones al inglés de Clare Cavanagh. Como punto de partida tomamos la noción de «pensamiento lateral», propuesta por Edward de Bono y reconocida por Albrecht Neubert como muy útil en el proceso de descubrimiento de nuevas posibilidades en la traducción. Tal enfoque permitirá reconocer que el potencial recreativo puede revelarse tanto en una traducción literal como libre. También consideraremos si los versos polacos pueden formar parte de los contextos poéticos de destino con una expresividad análoga.
Gender stereotypes in Jordanian commercial advertisements: Translation and ideology
Authors: Shraideh Khetam , Abdul-Hadi Lubna A.
Published: January 2025

En la sociedad jordana, la publicidad desempeña un papel clave en la formación de la percepción de la mujer en el mundo. Este estudio examina la representación de la mujer en los anuncios comerciales para exponer la misoginia arraigada en las campañas publicitarias que circulan en Jordania. Se recopilaron anuncios árabes en la calle y en las redes sociales de 2014 a 2022 y se compartieron con veintidós traductores noveles y experimentados de Jordania a través de una encuesta digital. El estudio evalúa cómo la ideología del texto de origen influye en las decisiones de los traductores al inglés. El análisis muestra que los traductores, independientemente de su experiencia, favorecen las traducciones neutras desde el punto de vista del género, lo que garantiza la subversión de los estereotipos. Destaca que adherirse a la traducción literal entraña el riesgo de respaldar estereotipos ofensivos y sexismo. Esto pone de relieve la importancia de adoptar un enfoque funcional de la traducción para contrarrestar las representaciones estereotipadas de la mujer en la publicidad.
FEMINIST REIMAGINING IN FAIR ROSALINE: NATASHA SOLOMONS’ REVISION OF ROMEO AND JULIET THROUGH HAROLD BLOOM’S REVISIONARY RATIOS
Authors: Emanuelle Glory , Zahroh Adiba Qonita
Published: January 2025

The growing inclusivity in today’s literary world offers female writers the chance to explore a wide range of themes even those that were previously considered exclusive for male writers. It led to the re-examination and reinterpretation of classic literature through a feminist lens. This study seeks to provide a comprehensive analysis of Natasha Solomons’ Fair Rosaline through the lens of Harold Bloom’s “Revisionary Ratios.” This paper employs mainly qualitative research design by combining textual analysis and comparative literary criticism to explore Natasha Solomons’ Fair Rosaline as a feminist reinterpretation of Shakespeare’s Romeo and Juliet through the lens of Harold Bloom’s “Revisionary Ratios” theory and feminism literary theory. The texts of Fair Rosaline and Romeo and Juliet serve as the primary data. Not only that this research adds to the larger discussion concerning the place of women in literature while also improving our understanding of Fair Rosaline and its connection to Romeo and Juliet, but also offers new insights into how feminist writers reimagine classical texts and empower female narratives with new, critical perspectives.
The Secondary Data Analysis on the Impact of Corporate Social Responsibility (CSR) towards the Competitiveness of Sharia Corporations in the International Market
Authors: Yusup Akhmad , Popon Srisusilawati  , Cecep Soleh Kurniawan
Published: January 2025

In an era where corporate ethics are increasingly scrutinized, the question arises: can social responsibility truly enhance a company's competitive edge? This study aims to analyze the impact of Corporate Social Responsibility (CSR) on the competitiveness of Sharia companies in the international market. Using a quantitative approach and secondary data from 30 Sharia companies listed on the stock exchange during the period of 2015-2023, this research found a significant positive relationship between CSR and the competitiveness of companies. The regression analysis results indicate that each one-unit increase in CSR value is associated with a 0.45 unit increase in company competitiveness. These findings suggest that Sharia companies actively engaged in CSR not only enhance their reputation but also strengthen their position in the international market. This research contributes significantly to the understanding of the role of CSR in the business strategies of Sharia companies.
Starfsmannavelta meðal kennara í grunnskólum árin 1998 til 2020
Authors: Björnsdóttir Amalía , Hansen Börkur
Published: January 2025

Tilgangur þessarar rannsóknar var að kanna starfsmannaveltu grunnskólakennara en bæði var verið að kanna hvenær kennarar hættu störfum og í hvaða mæli þeir flyttu sig milli skóla og svæða. Notuð voru gögn frá Hagstofu Íslands sem ná yfir tímabilið 1998 til 2020. Áhyggjur af kennaraskorti í grunnskólum hér á landi eru ekki nýjar af nálinni. Bæði veldur áhyggjum að ekki brautskrást nægilega margir kennarar á ári, að þeir sem brautskrást skili sér ekki til kennslu og margir starfandi kennarar hverfi frá störfum. Erlendar rannsóknir sýna að mikil starfsmannavelta í skólum hefur neikvæð áhrif á skólastarf og að starfsmannavelta meðal kennara er víða mikil, en mismunandi eftir löndum og landsvæðum. Niðurstöður þessarar rannsóknar sýna að um 7,5% þeirra sem voru við störf árin 1998 til 2018 voru ekki við störf árið eftir. Þessi tala var lægri, eða 6,3%, 2009 til 2013, árin eftir efnahagshrunið 2008, en rannsóknir sýna að á landsvæðum þar sem efnahagsástand er lakara gengur mönnun skóla betur en á svæðum þar sem hagsæld er meiri. Athygli vakti hve meðalaldur þeirra sem koma nýir til starfa er hár en það endurspeglar háan meðalaldur kennaranema og þá sérstaklega þess stóra hóps sem er í fjarnámi. Einnig virðast stórir hópar hverfa úr starfi löngu fyrir hefðbundinn eftirlaunaaldur. Kennarar eru ekki mikið að færa sig á milli skóla eða svæða en athygli vekur hversu hátt hlutfall þeirra staldrar stutt við í starfi. Starfsmannavelta meðal kennara í litlum skólum er þó meiri en í stærri skólum. Niðurstöðurnar benda til þess að vandi við mönnun kennarastéttarinnar sé margþættur, bæði þarf nýliðun að vera meiri en einnig þarf að gera starfið og starfsaðstæður áhugavert og aðlaðandi þannig að kennarar haldist í starfi.
Heparinized venous blood gas syringes are associated with a significant decrease in measured packed cell volume in dogs due to hemodilution
Authors: Hopey Coyne M. , Caldwell Dana , Binagia Erin , Keys Deborah A. , Stastny Tereza
Published: January 2025

OBJECTIVE

To assess the effect of hemodilution on PCV when commercial preheparinized venous blood gas (PH-VBG) syringes are used compared to directly filled Hct tubes, and to evaluate the impact of delayed centrifugation on PCV.

METHODS

A prospective study of 102 dogs presenting to a private emergency department between November 1, 2023, and February 29, 2024, with 306 corresponding blood samples. Samples were collected by direct venipuncture. Samples were analyzed with the use of 3 methods: directly filled microhematocrit tubes (direct), PH-VBG syringe (PH-VBG), and PH-VBG syringe with a 15-minute delay before centrifugation (delayed PH-VBG).

RESULTS

Mean PCV of the direct method was 43.9%, the PH-VBG method was 41.7% (range, 11.0% to 60.0%; SD, 9.8%), and the delayed PH-VBG method was 40.1% (range, 7.0% to 60.0%; SD, 11.2%). When the direct and PH-VBG methods were compared, the direct method was biased on average 2.2% higher than the PH-VBG method, with limits of agreement (LOAs) of –0.9 to 5.3. The direct method was biased on average 3.8% higher than the delayed PH-VBG method, with LOAs of –4.3 to 11.9. In anemic dogs (n = 14), the direct method was biased on average 6.1% higher than the delayed PH-VBG method, with LOAs of –0.05 to 12.2. In nonanemic dogs (n = 88), the direct method was biased on average 2.3% higher than the PH-VBG method, with LOAs of –0.9 to 5.4.

CONCLUSIONS

Use of preheparinized syringes and delayed sample processing led to hemodilution and lower PCV values.

CLINICAL RELEVANCE

Direct venipuncture and immediate sample processing are recommended to ensure accurate PCV results.
The necessity of a new approach in the legal migration policies of the EU due to discrimination in the labor market, considering the post-Covid 19 context
Authors: Arrinaj Florida
Published: January 2025

The global trends in the labor market and the dynamics surrounding migration for employment have become a highly debated and prominent issue within the EU. Labor migration policies within the EU have undergone significant reforms over the years. These changes aim to address the evolving needs of the labor market while managing the migration of workers for employment purposes. This article examines the impact of the EU Blue Card Directive, the Seasonal Workers Directive and the Single Permit Directive on the labor market, with a particular focus on the issues and challenges faced by third country nationals. A valuable contribution has been made in attracting qualified labor force, but on the other hand, these policies have not managed to meet all the needs of migrant workers, especially those with low and medium qualifications. The COVID-19 pandemic has further highlighted the vulnerability of migrant workers, worsening pre-existing disparities in their access to employment opportunities, social services, and labor rights. These precarious conditions have exposed the shortcomings of existing labor migration policies, emphasizing the need for comprehensive reforms that address these inequalities and offer better protection for migrant workers in the post-pandemic context. The post-pandemic period has highlighted the urgent need for comprehensive reforms that not only support economic recovery, but also promote social inclusion and fair treatment of migrant workers. This article will propose recommendations to enhance EU migration policies by focusing on the development of legal migration pathways, implementing anti-discrimination measures, and strengthening integration initiatives. These changes are essential to creating a more equitable and resilient labor market in the EU, fostering better opportunities and protections for migrant workers and promoting social inclusion.
Suspension of sentencing of revised decisions, legal provision and enforcement in practice
Authors: Kllapi Sotir , Shehaj Enerjeta
Published: January 2025

The review of a final criminal decision is an extraordinary appeal instrument, because it does not follow the usual rules of appeal. This is related to subjects, deadlines and cases. The review, at first glance, seems to be a violation of the principle of legal certainty, because it is intended to review, retry a final decision, but in fact it is the opposite. The purpose of the review is essentially that of effective justice, that justice which must be done at all times, irrespective of the fact that the sentence imposed by the final decision may be fully served or extinguished. The review institute has undergone legal reforms in order to increase efficiency and respond to the needs of time. The legal reform of this institute aimed to expand the ratifications, adding in addition to the issues of fact and issues of law, but also issues of the right to a fair legal process. The legal reform was also in line with the evolving jurisdiction of the ECHR, but also of Albania’s Constitutional Court. Along with the reform for review, changes were also made to the institute of suspension of the execution of the final sentence, when the request for review of the decision is accepted. Suspension as an institute seems an effective means when it comes to suspending a final decision, which should not be executed because it is being reviewed.

The lawmaker has left the implementation of this institute in the hands of the court, which on a case-by-case basis can assess whether it can impose the suspension or not? This increased discretion of the court and the lack of a clear legal regulation has brought problems in practice, with different interpretations of this institute. From practice we have noticed that often the criteria for deciding whether to suspend or not when the request for review is accepted is objective, but there have been no subjective criteria. In these conditions, arises the need to make a clear legal adjustment as to when the suspension should be imposed and when not, or to have a unification of practice by Albania’s High Court, in relation to legal cases as to when it should be accepted or not and what legal criteria should be considered in approving or rejecting this request.
Knowledge, attitude, and practices of cosmetic procedures among Bisha population
Authors: Alam Munir , Alaklabi Sami , Alalyani Salem , Alamri Yaser , Alshmrani Saud , Alamri Turki , Alharethi Sultan , Albogami Sultan , Alamri Malik , Alaklabi Turki
Published: January 2025

Objective:
This study aimed to assess the knowledge, attitude, and practice of cosmetic procedures among the Bisha population.
Methods:
This study adopted a cross-research design from January 2024 to June 2024. It involved 388 residents of Bisha, Saudi Arabia. Data were collected using an online questionnaire.
Results:
Almost half of the participants (47.2%) had previous knowledge about cosmetic procedures. The most commonly known non-surgical cosmetic procedure was filler injections (40.2%), while the most prevalent surgical procedure was rhinoplasty (60.3%). Most participants believed the primary motivation for undergoing cosmetic procedures was to improve appearance (59.3%). Exactly three-quarters of the participants (75.0%) felt that low self-esteem was the primary motivation for cosmetic procedures. An overwhelming majority (92.3%) believed that cosmetic procedures were more prevalent among women than men. In terms of practice, only (35.6%) of the participants had undergone cosmetic procedures, with rhinoplasty (8.0%) being the most common surgical procedure. The only social demographic variable that demonstrated statistical significance with cosmetic procedure knowledge was gender (p-value=0.003).
Conclusion:
Nearly half of the participants knew cosmetic procedures, with rhinoplasty and liposuction being the most recognized surgical procedures, and filler injections and hair removal being the leading non-surgical options. The main motivations for undergoing cosmetic procedures include the desire to improve appearance and address low self-esteem, with a significant gender disparity favoring females in knowledge levels. Despite the high awareness, hesitancy persists due to fears of complications and religious beliefs.
PREVENTION OF PATHOLOGICAL CONDITIONS IN ATHLETES IN THE FAR NORTH. LITERATURE REVIEW
Authors:   Khanty-Mansiysk State Medical Academy, Batantsev Nikolay Ivanovich , Dudko Andrey Vasilievich , Tsyndrina Alena Vladimirovna
Published: January 2025

The article examines the influence of the conditions of the Far North on the body, namely, a complex change in the indicators of various physiological systems, which is directly related to the climate characteristics of this territory. Adaptation to low environmental temperatures is manifested by a decrease in heat transfer and an increase in thermal production, accompanied by changes in hormonal levels. It has been revealed that hypoxia and hormonal changes have a serious impact on the cardiovascular system. Despite unfavorable climatic conditions and possible complications from the cardiovascular system, aerobic exercise and weight loss are recommended. The most effective methods for preventing pathological conditions in athletes in the Far North have been identified.
CLINICAL CASE OF ANTEGRADE RECANALIZATION OF CHRONIC OCCLUSION OF THE RIGHT CORONARY ARTERY
Authors:   Khanty-Mansiysk State Medical Academy, Abdalieva Azizakhon Zhalaliddinovna , Pavlov Prokhor Igorevich ,   Regional Hospital of Khanty-Mansiysk autonomus District – Ugra, Dolgushin Vadim Sergeevich
Published: January 2025

Chronic total occlusion of coronary arteries (CTO) is the absence of antegrade blood flow through a coronary artery for more than 3 months. CTO is found in 18–52% of cases during routine coronary angiography and 10– 15% in acute coronary syndrome. This pathology is the most severe in terms of stenosis and endovascular treatment. A common cause of failure is the inability to advance a guidewire into the distal vessel and into the true lumen of the coronary artery
THE RELATIONSHIP BETWEEN METABOLIC SYNDROME AND UTERINE CANCER
Authors:   Gomel State Medical University, Pinchuk Dmitriy Nicolaevich , Sergeenko Kristina Victorovna
Published: January 2025

Cancer of the uterine body against the background of metabolic syndrome is an important problem. It is associated with the growing pandemic of obesity, elevated glucose and cholesterol levels, accompanied by arterial. hypertension.
SECONDARY PHLEBOHYPERTENSIVE GLAUCOMA ASSOCIATED WITH THROMBOSIS OF THE CAVERNOUS SINUS (CLINICAL CASE)
Authors:   Khanty-Mansiysk State Medical Academy, Vashkulatova Elvira Aysarovna , Samoylova Uliya Viktorovna ,   Regional Hospital of Khanty-Mansiysk autonomus District – Ugra, Abdurazakova Gozel Akhmadievna ,   Khanty-Mansiysk State Medical Academy
Published: January 2025

This paper presents data on the diagnostic search and management tactics of a patient with secondary
phlebohypertensive glaucoma against the background of cavernous sinus thrombosis
ANALYSIS OF THE RESULTS OF TREATMENT OF NEOVASCULAR AGE-RELATED MACULAR DEGENERATION OF THE RETINA IN THE OPHTHALMOLOGICAL CENTER OF THE BU “DISTRICT CLINICAL HOSPITAL” KHANTY-MANSIYSK
Authors:   Khanty-Mansiysk State Medical Academy, Zhalbe Ksenia Petrovna , Vashkulatova Elvira Aysarovnа
Published: January 2025

The article presents an analysis of the results of the modern method of treatment of neovascular agerelated macular degeneration of the retina used in the ophthalmological center of the District Clinical Hospital of KhantyMansiysk.
THE RESULTS OF DIAGNOSIS AND TREATMENT OF ACUTE ILEOPSOITIS ACCORDING TO THE DATA OF THE SURGICAL DEPARTMENTS OF GBUZ "KBSMP" OF THE MINISTRY OF HEALTH OF THE CITY OF KRASNODAR
Authors:   Federal State Budgetary Educational Institution of Higher Education "Kuban State Medical University", Bazlov Sergey Borisovich , Kulikova Irina Alexandrovna
Published: January 2025

Statistical data on the effectiveness of various tactics for the treatment of acute ileopsoitis, selected on the basis of a set of indicators of clinical and radiation criteria, are presented.
NUTRITION ANALYSIS OF HMGMA STUDENTS
Authors:   Khanty-Mansiysk State Medical Academy, Gurbanova Velina Rasimovna , Shapovalova Maria Viktorovna
Published: January 2025

Recently, the problem of malnutrition has been quite acute: a high degree of overweight, hypovitaminosis, microelementosis. Students are also at risk of the consequences of poor nutrition. Lack of time, material limitations, often low motor activity, non-compliance with work and rest, mental stress – all this, combined with improper nutrition, can lead to negative consequences for the student's body.
INFLUENCE OF MEMANTINE AND THYMOQUINONE ON THE ACUTE PERIOD OF ISCHEMIC STROKE IN RATS
Authors:   Belarusian State Medical University, Strunevsky Vsevolod Aleksandrovich , Shishkina Tamara Aleksandrovna , Rashkevich Olga Sergeevna , Vauchok Aliaksandr Uladzimiravich
Published: January 2025

In a model of ischemic cerebral stroke in rats caused by photo-induced thrombosis of the vessels of the upper surface of the cerebral hemispheres, memantine, with a single intraperitoneal prophylactic administration at a dose of 5 mg/kg, had a significant neuroprotective effect, reducing the necrosis zone to 20 ± 2.6%. The proportion of non-viable surface area of the cerebral hemispheres in rats receiving placebo was 38 ± 2.3%. Thymoquinone at a dose of 5 mg/kg reduced the area of rat cerebral cortex tissue that was not viable due to stroke to 25 ± 5.3%, and at a dose of 10 mg/kg – to 18 ± 5.9%. In the “open field”, the active-search component of the behavior of animals receiving thymoquinone at a dose of 10 mg/kg was more than 5 times higher than that of placebo and memantine. Thus, memantine at a dose of 5 mg/kg and thymoquinone at doses of 5 and 10 mg/kg with a single intraperitoneal administration have a pronounced cerebroprotective effect in ischemic stroke in rats.
FEATURES OF ORAL HYGIENE FOR STUDENTS OF THE FACULTY OF DENTISTRY
Authors:   Order of the Red Banner of Labor Medical Institute named after. S.I. Georgievsky, Kirbabin Sergey Sergeevich , Khalilova Arzy Server kizi
Published: January 2025

Oral hygiene is a key aspect of health care. This scientific article examines the characteristics of oral hygiene among students of the Faculty of Dentistry. The habits and knowledge of students in the field of oral care are analyzed, and the main problems and errors in the approach to hygiene are identified. The study is conducted with the aim of increasing the effectiveness of the prevention of dental diseases among future specialists.
SEX AND AGE CHARACTERISTICS OF CHILDREN WITH ATOPIC DERMATITIS AND CHANGES IN THE COMPOSITION OF INTESTINAL BIOCENOSIS
Authors:   Gomel State Medical University, Sadchenko Polina Sergeevna , , Ilyushenko Dmitry Sergeevich
Published: January 2025

Due to the obvious deterioration of the environmental situation throughout the world, an increasing commitment to replacing natural food components with synthetic one, increasing in the proportion of comorbid pathologies per capita, the development of allergic dermatoses, including atopic dermatitis, is stimulated.
THE PROBLEM OF BANNING ABORTIONS IN PRIVATE CLINICS: CAUSES AND CONSEQUENCES
Authors:   Kursk State Medical University, Simonyan Rimma Zorikovna , Khachatryan Vera Arturovna
Published: January 2025

This article is devoted to discussing the problem of banning abortions in private medical clinics. The article examines the main reasons that may lead to the adoption of legislative restrictions in this area, as well as examines the possible consequences of such actions. The socio-cultural, religious and legal aspects of this problem are also analyzed, highlighting the positions of various parties to the conflict.
THE EFFECTIVENESS OF PASSIVE IMMUNIZATION AGAINST RSV INFECTION IN CHILDREN AT RISK IN KHANTY-MANSIYSK
Authors:   Khanty-Mansiysk State Medical Academy, Shumilova Yulia Vladislavovna , Lysenkova Ekaterina Sergeevna
Published: January 2025

Respiratory syncytial infection (RSV) is the main cause of severe bronchiolitis in children in the first years of life. The world has accumulated experience in passive immunization through the use of the drug Palivizumab. In the Russian Federation, palivizumab was registered and approved for use in 2010. In children receiving palivizumab, RSV infection is absent from the incidence of respiratory infections [1]. Since 2021, the prevention of RSV infection in children at risk in the Khanty-Mansi Autonomous Okrug – Yugra has begun. An analysis of the effectiveness of the drug was carried out in Khanty-Mansiysk. It was established that there were no cases of acute bronchiolitis among children who received palivizumab at the Khanty-Mansiysk Regional Clinical Hospital.
Adaptation of Menstrual Attitude Questionnaire for Gwalior Region, India
Authors: Chandani Jennifer , Nagaich Dr. N.K.
Published: January 2025

The purpose was to adapt the Menstrual Attitude Questionnaire Indian Version by Chandra, Chaturvedi and Isaac developed in 1989, which itself was a modified and abridged version of Menstrual Attitude Questionnaire developed originally by Brooks-Gunn and Ruble in 1980. Attitudes tend to change and hence there was a need to adapt this more than three-decades old questionnaire so as to make it more suitable for use in the current times. Additionally, their sample consisted of the females from the southern part of India. The proposed questionnaire was meant to be used for the first author’s PhD data collection in Gwalior, Madhya Pradesh, India. Due to the cultural differences, the need to adapt it for the females of the northern part of India also seemed important. Three females were shown the original questionnaire initially to check face validity. Apart from the other suggestions, it was recommended that the items be translated in Hindi for the local women in Gwalior to comprehend the items in English better. Later, 16 domain experts (doctors, mental health professionals and local women) were shown the questionnaire with the items in English along with Hindi (conceptual translation) for their feedback. Suggestions were incorporated in the final draft accordingly and the items were rechecked with back-translation. Semantical challenges and issues pertaining to interpretation and understanding of the items were found. Items related to religious beliefs and preferences for sexual activities were considered as controversial by many domain experts and hence removed from the final draft. Additionally, an English phrase presented semantic difficulties. Grammar and sentence structure-related issues were also considered. The total number of items were reduced from 30 to 27.
Antibiotic loaded biodegradable polymeric based micro/nanoparticles potentials for multidrug resistant bacteria treatment
Authors: Kasem Basam Mahmoud
Published: January 2025

The spread of the antibiotic-resistant bacteria has become a serious global concern that demands the implementation of remedial strategies to control this health-threatening problem, different approaches have been investigated, and using nano-materials represents one of the promising strategies, and the biodegradable polymeric micro/nano-particles may be a good candidate owing to its low cytotoxicity, bio-compatibility, selectivity, and the ability to release the loaded antibiotic in a precise sustained and controlled manner, in addition to an alteration of the antibiotic/microbial cell interaction mode. This review will shed light on using antibiotic loaded biodegradable polymeric micro/nanoparticles as a platform for more efficient treatment of antibiotic resistant bacteria.
Antibiotic resistance and biofilm formation in Cutibacterium acnes: A descriptive cross-sectional study
Authors: Paul Navya Anna , Bhat M Ramesh , Antony Beena , Jayaraman Jyothi
Published: January 2025

Background

The issue of antibiotic resistance in acne vulgaris has emerged as a significant concern in recent times. Though the ability of Cutibacterium acnes to form biofilms have been established, its role in acne vulgaris has yet to be ascertained.

Aims

This descriptive cross-sectional study was aimed to investigate the ability of C. acnes to form biofilms and its potential association with resistance to the commonly used antibiotics.

Methods

A total of 88 patients with acne vulgaris were selected for this study. Clinical examination and severity grading was done. The collected samples were analysed with Matrix-Assisted Laser Desorption Ionization Time of Flight Mass Spectrometry (MALDI-TOF-MS) and further subjected to biofilm testing using the microtiter plate assay.

Results

C. acnes were isolated from 43.1 of the samples (n = 38). The highest resistance was observed with azithromycin (73.7%) followed by clindamycin (65.8%), doxycycline (15.8%), ampicillin (31.6%) and minocycline (5.3%). Thirty-seven per cent of the isolates were resistant to at least two antibiotics, 63.2% of C. acnes had a weak capacity to form biofilms and more than 60 percent of the isolates showed resistance to atleast two types of antibiotics as well as weak biofilm forming capacity.

Limitations

Single-centre study, small sample, long-term follow-up of the patients was not done. In addition, this study is representative of only C. acnes species.

Conclusion

While C. acnes have the ability to create biofilms, its effectiveness in antibiotic resistance can be deemed as modest based on the findings of this study. It is important to consider alternative mechanisms such as genetic or biochemical plasticity that may contribute to antibiotic resistance.
Dengue-associated autoimmune encephalitis presenting as a dystonic storm in a young male: A rare case report
Authors: Sidharth S. , Vibha Deepti , Singh Rajesh Kumar , Tripathi Manjari , Elavarasi Arunmozhimaran , Gaikwad Shailesh B. , Mishra Biswamohan
Published: January 2025

While dengue fever is known to cause various neurological manifestations, such as dengue encephalitis and post-infectious immune-mediated syndromes, Autoimmune Encephalitis (AIE) following dengue remains an under-recognized entity. We report a case of a young male who presented with refractory seizures and a dystonic storm following recovery from dengue fever. Despite normal magnetic resonance imaging findings, 18F-FDG PET imaging revealed hypermetabolism in the basal ganglia and hippocampus, suggestive of AIE. Notably, the autoimmune and paraneoplastic panel was negative. The patient demonstrated a marked clinical response to immunotherapy, underscoring the importance of early recognition and treatment. This case highlights the need for clinicians to consider AIE as part of the spectrum of post-dengue neurological complications, even in the absence of typical imaging findings, to facilitate timely diagnosis and intervention.
Assessing the potential of combined Bio control agents (Fungi and Bacteria) and AM fungi for enhancing turmeric resistance to Pythium aphanidermatum: A pot study with focus on Biometric, Disease and Enzymatic parameters
Authors: Vigneshwaran K. , Rajamohan K. , Sivasakthivelan P.
Published: January 2025

Turmeric (Curcuma longa L.) is one of the important spice crops grown in India since time immemorial and has a potential to earn foreign exchange because of its wide utilization in Ayurvedic industry. Turmeric belongs to the family Zingiberaceae. Turmeric is the third largest spice produced in the country and it accounts for about 14 % of total spices produced in India. Though it is well known for its medicinal value, its cultivation is hindered by several diseases. Among the various diseases, rhizome rot caused by Pythium sp. is a major problem in all turmeric growing areas of India. Its damage leads to 90-100% yield loss. The present studies emphasised on AM fungi (Glomus mossae) and antagonists (Trichoderma asperellum and Bacillus subtilis) against the rhizome rot of turmeric caused by P. aphanidermatum.

In pot culture experiments, the combined application of T. asperellum RT (10 ml kg-1) + SA (5 ml kg-1) and B. subtilis RT (10 ml kg-1) + SA (5 ml kg-1) plus G. mosseae @ SA (20 g pot-1) –(T7) recorded the minimum Rhizome rot incidence and maximum plant growth promotion of turmeric. The same treatment showed earlier induction and increased levels of defence enzymes viz. PO, PPO, PAL and β1,3- glucanase.In field trial, the combined application of T. asperellum RT (10 ml kg-1) + SA (2. 5 lit ha-1) and B. subtilis RT (10 ml kg-1) + SA (2.5 lit ha-1) plus G. mosseae @ SA (20 kg ha-1)– (T7) reduced rhizome rot incidence to the minimum and increased the biometrics of turmeric to the maximum.
Physico-chemical properties and Manganese concentration effects on biochemical activities in cereals crops grown in degraded soil
Authors: Verma Rahul , Singh Swati , Singh Amit Kumar
Published: January 2025

Degraded soil has now become an important factor in agricultural economy. Human activities are responsible for land degradation, as construction of large-scale canals for irrigation purposes, deforestation and faulty land use, salinization, drought and water-logging. These processes also reduce the availability of essential minerals. Manganese is an essential micronutrient for plant growth, development and intervening in several type of metabolic activity, mainly in photosynthesis and chlorophyll concentration in different types of plants. Manganese is also essential co-factor for the oxygen-evolving complex of the photosynthetic machinery of plants life cycle and catalyzing the water-splitting reaction in photosynthetic- II process.

Nevertheless, excess amount of Manganese is available in soil for plant affecting the plant’s growth and become toxic for them. Manganese phytotoxicity is manifested in the reduction of plant biomass, photosynthetic rate and different type of bio-chemical disorders like; oxidative stress, chlorosis on young leaves, necrotic dark spot on mature leaves and crinkled leaves. An important role of antioxidative system in plant in high amount of Manganese has been also reported as a defense mechanism for plants. In the collected sample of degraded soil, the availability of different types of elements is very poor in concentration and other physico-chemical properties are also reduced in degraded soil.
A study on the effects of El Nino and global warming in India: Climatic changes, issues and challenges
Authors: Srinivasa Rao D. , Babji Prasad Ch.
Published: January 2025

El Nino is a climatic phenomenon that constantly increases temperatures at the ocean level in the middle and eastern Pacific Ocean, which influences worldwide weather patterns. Global warming is the progressive increase in the Earth's average surface temperature caused by human activity, primarily the release of greenhouse gases, which alters the climate and has other severe environmental effects. Both El Nino and global warming have profound effects on India. El Nino disrupts the monsoon, leading to droughts or excessive rainfall, while global warming exacerbates this, intensifying heat waves and altering precipitation patterns.

This study explores how El Nino and global warming affect India's economy and society. It examines their impact on agriculture, water resources, public health, the environment and livelihoods. Further, this study highlights the need to implement effective measures across sectors to strengthen climate resilience and to provide better coping with the impacts of El Nino, safeguarding socio-economic systems and promoting sustainable development.
Disorder Solutions for Generalized Ising and Potts Models with Multispin Interaction
Authors: Khrapov P.V.
Published: January 2025

In this work, a special elementary transfer matrix is constructed for generalized Ising models and Potts models with the general form of a finite Hamiltonian with a multi-spin interaction in a space of arbitrary dimensionality, the Napierian logarithm of its maximum eigenvalue is equal to the free energy of the system. In some cases, it was possible to obtain an explicit form of the eigenvector corresponding to the largest eigenvalue of the elementary transfer matrix. On this basis we obtained systems of nonlinear equations for the interaction coefficients of the Hamiltonian for finding the exact value of the free energy on a set of disorder solutions. Using the Levenberg-Marquardt method, the existence of nontrivial solutions of the resulting systems of equations for plane and three-dimensional Ising models was shown. In some special cases (the 2D Ising model, the interaction potential, including the interaction of the next nearest neighbors and quadruple interactions; the 3D model with a special Hamiltonian symmetric relative to the change of all spin signs, for which it is possible to reduce the system of equations to the system for a planar model) three parameters are written in explicit form. The domain of existence of these solutions is described.

В работе построена специальная элементарная трансфер-матрица для обобщенных моделей Изинга и моделей Поттса с общим видом финитного гамильтониана с мультиспиновым взаимодействием в пространстве произвольной размерности, натуральный логарифм максимального собственного значения которой равен свободной энергии системы. В некоторых случаях удалось получить явный вид собственного вектора, отвечающего наибольшему собственному значению элементарной трансфер-матрицы. На основе этого выведены системы нелинейных уравнений на коэффициенты взаимодействия гамильтониана для нахождения точного значения свободной энергии  на множестве неупорядоченных решений (disorder solutions). Методом Левенберга-Марквардта показано существование нетривиальных решений получающихся систем уравнений для плоских и трехмерных моделей Изинга. В некоторых частных случаях (2D модель Изинга, потенциал взаимодействия, включающий взаимодействие следующих ближайших соседей и четверные взаимодействия; 3D модель со специальным гамильтонианом, симметричным относительно перемены всех знаков спинов, для которой удается свести систему уравнений к системе для плоской модели) решения, зависящие от трех параметров, выписаны в явном виде. Описана область существования этих решений.
Biochemical method for determining the readiness of burn wounds for autodermoplasty
Authors:   FSBEIoHE Astrakhan State Medical University, Kchibekov E.A. , Melnikova K.Yu. ,   FSBEIoHE Astrakhan State Medical University, Zurnadzhyants V.A. ,   FSBEIoHE Astrakhan State Medical University
Published: January 2025

The choice of tactics for surgical treatment of burn injury mainly depends on the course of the injury process, the presence of inflammatory changes in the wound, the addition of pathogenic microbial flora, the state of the body's immune system and the presence of concomitant pathology. Determining the optimal and early terms for autodermoplasty is of particular importance in severely burned patients with a large deficit of donor resources. Therefore, the issues of determining the readiness of the burn injury surface for skin graft transplants remain relevant at present, and the search for solutions to this problem continues. The purpose of the study is to study injury discharge from the surface of burn injuries with the determination of biochemical indicators of total protein and fibrinogen and the level of bacterial contamination to develop a method for determining the readiness of burn injuries for autodermoplasty. Materials and methods. To achieve the stated objective, 70 samples of biochemical analyses of total protein and fibrinogen of injury discharge, as well as bacterial cultures with determination of the level of bacterial contamination of injuries, taken from 19 patients with deep burns of III (IIIb-IV) degree were studied. Autodermoplasty was planned for all patients during treatment. Injury discharge sampling was collected for studying the concentrations of biochemical markers and determining bacterial contamination the day before plastic surgery. Results and discussion. The analysis of the data revealed statistically significant high levels of total protein and a decrease in fibrinogen levels in wound discharge with a degree of contamination of burn injuries ≤ 103 CFU/g, than with higher levels of bacterial contamination of the injury. Based on the results obtained, a method was developed for determining the readiness of the burn injury surface for autodermoplasty. Conclusion. Determining the degree of readiness of burn injuries for plastic surgery, according to the proposed method, allows you to quickly obtain and analyze data on the state of the injury process and simultaneously determine the tactics of surgical treatment in burn patients.
Key words: burn injury, autodermoplasty, fibrinogen, total protein