bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring cotton water status with microtensiometers
Authors: Christenson Clay G. , Gohardoust Mohammad R. , Calleja Sebastian , Thorp Kelly R. , Tuller Markus , Pauli Duke
Published: April 2024

Stem water potential (Ψstem) is a key indicator for assessing plant water status, which is crucial in understanding plant health and productivity. However, existing measurement methods for Ψstem, characterized by destructiveness and intermittency, limit its applicability. Microtensiometers, an emerging plant-based sensor, offer continuous monitoring capabilities and have shown success in certain vine and tree species. In this study, we investigate the efficacy of microtensiometers ability to monitor the Ψstem of cotton (Gossypium hirsutum L.) under three distinct irrigation treatments in Maricopa, Arizona, an extremely hot, arid environment. We analyze the diurnal dynamics of Ψstem across the irrigation regimes and compare these measurements with midday leaf water potentials (Ψleaf) obtained using a dewpoint potentiometer. Our results demonstrate that the microtensiometer-derived Ψstem closely follows known diurnal patterns of Ψleaf, tracking with vapor pressure deficit (VPD) and responding to variations in irrigation levels and soil moisture content. Time cross-correlation analysis reveals an 80-minute lag in Ψstem response to changing VPD under non-water limiting conditions, which shortens under water-limiting conditions. Additionally, we establish a robust linear relationship (R2adj = 0.82) between Ψstem and Ψleaf, with this relationship strengthening as water availability decreases. Notably, we observe mean gradients of 1.2 and 0.06 MPa between soil vs. stem and stem vs. leaf water potentials, respectively. Moreover, Ψstem data proves to be more sensitive in distinguishing between irrigation treatments earlier in the growing season compared to Ψleaf, leaf temperature and leaf gas exchange parameters. These findings highlight the utility of microtensiometers as valuable tools for monitoring water status in smaller-stemmed row crops such as cotton.
Infection-induced increases to population size during cycles in a discrete-time epidemic model
Authors: Strube Laura F. , Elgart Shoshana , Childs Lauren M.
Published: April 2024

One-dimensional discrete-time population models, such as those that involve Logistic or Ricker growth, can exhibit periodic and chaotic dynamics. Expanding the system by one dimension to incorporate epidemiological interactions causes an interesting complexity of new behaviors. Here, we examine a discrete-time two-dimensional susceptible-infectious (SI) model with Ricker growth and show that the introduction of infection can not only produce a distinctly different bifurcation structure than that of the underlying disease-free system but also lead to counter-intuitive increases in population size. We use numerical bifurcation analysis to determine the influence of infection on the location and types of bifurcations. In addition, we examine the appearance and extent of a phenomenon known as the ‘hydra effect,’ i.e., increases in total population size when factors, such as mortality, that act negatively on a population, are increased. Previous work, primarily focused on dynamics at fixed points, showed that the introduction of infection that reduces fecundity to the SI model can lead to a so-called ‘infection-induced hydra effect.’ Our work shows that even in such a simple two-dimensional SI model, the introduction of infection that alters fecundity or mortality can produce dynamics can lead to the appearance of a hydra effect, particularly when the disease-free population is at a cycle.
On the relation of CMIP6 GCMs errors at RCM driving boundary condition zones and inner region for Central Europe region
Authors: Holtanová Eva , Belda Michal , Crespo Natália Machado , Halenka Tomáš
Published: April 2024

Global climate models (GCMs) are essential for studying the climate system and climate change projections. Due to their coarse spatial resolution, downscaling is necessary on the regional scale. Regional climate models (RCMs) represent a standard solution for this issue. Nevertheless, the boundary conditions provided by GCMs unavoidably influence the outputs of RCMs. This study evaluates CMIP6 GCMs regarding the variables relevant to RCM boundary conditions. Particular focus is on the simulation of CNRM-ESM2-1, which is being used as a driving model for convection-permitting ALARO-Climate RCM, used as one source feeding new Czech climate change scenarios. The analysis is conducted over the boundaries and inside the RCM integration domain. Firstly, an evaluation of CFSR and ERA5 reanalyses against radiosondes is performed to choose an appropriate reference dataset for upper air variables. A high correlation between the two studied reanalysis and radiosondes was revealed, and it slightly decreases at the upper tropospheric levels. ERA5 is then chosen as the reference for the boundary analysis. Over the inner region, the simulated mean annual cycle of impact-relevant variables is validated against E-OBS. The CNRM-ESM2-1 performs well regarding near-surface variables over the Czech Republic, but it exhibits larger errors along the boundaries, especially for air temperature and specific humidity. The GCM performance in simulating the upper air atmospheric variables used as RCM boundary conditions relates rather weakly to the GCM performance in simulating the near-surface parameters in the inner region in terms of parameters relevant for impact studies.
Association between dietary magnesium intake, inflammation, and neurodegeneration
Authors: Alateeq Khawlah , Walsh Erin I. , Ambikairajah Ananthan , Cherbuin Nicolas
Published: April 2024

Background

Consistent evidence shows that magnesium (Mg) intake is associated with lower blood pressure (BP), and that lower BP is associated with improved cerebral health. However, recent findings indicate that the positive effect of dietary Mg intake on cerebral health is not mediated by a decrease in BP. As Mg’s anti-inflammatory action is a plausible alternative mechanism, the objective of this study was to investigate the associations between Mg intake and inflammation to determine whether it mediates any neuroprotective effect.

Methods

Participants from the UK Biobank (n = 5775, aged 40–73 years, 54.7% female) were assessed for dietary magnesium using an online food questionnaire, brain and white matter lesion (WML) volumes were segmented with FreeSurfer software, and inflammation markers including high-sensitivity C-reactive protein (hs-CRP), leukocyte, erythrocyte count, and Glycoprotein acetylation (GlycA) were measured using specific laboratory techniques such as immunoturbidimetry, automated cell counting, and nuclear magnetic resonance. Hierarchical linear regression models were performed to investigate the association between dietary Mg, and inflammatory markers and between dietary Mg, brain and WMLs volumes. Mediation analysis was performed to test a possible mediation role of inflammation on the association between dietary Mg and brain and WMLs volumes.

Results

Higher dietary Mg intake was associated with lower inflammation: hs-CRP level (− 0.0497%; 95% confidence interval [CI] − 0.0497%,  − 0.0199%) leukocytes count (− 0.0015%; 95%CI − 0.00151%,  − 0.0011%), and GlycA (− 0.0519%; 95%CI − 0.1298%,  − 0.0129%). Moreover, higher dietary Mg intake was associated with larger grey matter volume (0.010%; 95%CI 0.004%, 0.017%), white matter volume (0.012%; 95%CI 0.003,  0.022) and right hippocampal volume (0.002%; 95%CI 0.0007, –0.0025%). Lower hs-CRP levels mediated the positive association between higher dietary Mg intake and larger grey matter volume.

Conclusions

The anti-inflammatory effects of dietary Mg intake in the general population, appears to mediate its neuroprotective effect.
Exploring the role of the human microbiome in forensic identification: opportunities and challenges
Authors: Franceschetti Lorenzo , Lodetti Giorgia , Blandino Alberto , Amadasi Alberto , Bugelli Valentina
Published: April 2024

Forensic microbiology is rapidly emerging as a novel tool for human identification. The human microbiome, comprising diverse microbial communities including fungi, bacteria, protozoa, and viruses, is unique to each individual, offering a new dimension to forensic investigations. While traditional identification methods primarily rely on DNA profiling and fingerprint analysis, they face limitations when complete DNA or fingerprints profiles are unattainable or degraded. In this context, the microbial signatures of the human skin microbiome present a promising alternative due to their resilience to environmental stresses and individual-specific composition. This review explores the potential of microbiome analysis in forensic human identification, evaluating its applications, advantages, limitations, and future prospects. The uniqueness of an individual’s microbial community, particularly the skin microbiota, can provide distinctive biological markers for identification purposes, while technological advancements like 16 S rRNA sequencing and metagenomic shotgun sequencing are enhancing the specificity of microbial identification, enabling detailed analysis of these complex ecological communities. Despite these promising findings, current research has not yet achieved a level of identification probability that could establish microbial analysis as a stand-alone evidence tool. Therefore, it is presently considered ancillary to traditional methods, contributing to a more comprehensive biological profile of individuals.
Characterisation of RT-QuIC negative cases from the UK National CJD Research and Surveillance programme
Authors: Ng Dominic , Watson Neil , McDermott Eugene Ace , Kurucu Hatice , Summers David , Andrews Mary , Green Alison , Barria Marcelo , McKenzie Janet , Tam Johnny , Smith Colin , Pal Suvankar
Published: April 2024

Introduction

Incorporation of the real-time quaking-induced conversion (RT-QuIC) assays for diagnosis of sporadic Creutzfeldt-Jakob disease (CJD) has transformed diagnosis largely related to its extremely high specificity. However, the test has a c.10% false-negative result and we aim to characterize the clinical features, investigation profile, and molecular subtype in this cohort of patients.

Methods

250 individuals diagnosed with definite sporadic CJD were identified from the UK National CJD Research and Surveillance Unit from 2012 to 2023. We compared the clinical features and investigation profile in those with a negative CSF RT-QuIC to those with a positive RT-QuIC.

Results

27 individuals (10.8%) were CSF RT-QuIC negative. Median age of onset was younger (62 years vs 68 years, p = 0.002), median disease duration was longer (4.4 months vs 10.5 months, p < 0.001), and these individuals were less likely to present with gait difficulties (73% vs 93%, p = 0.003) or motor symptoms (62% vs 80%, p = 0.04). The sensitivity of electroencephalography and diffusion-weighted MRI were similar in both groups. In those who were RT-QuIC negative, there was an overrepresentation of the VV1 (32% vs 1%) and MM2 molecular subtypes (21% vs 3%). Co-occurring neurodegenerative disease was found in 33% (9/27) of those who were RT-QuIC negative.

Conclusions

Individuals with sporadic CJD and a negative CSF RT-QuIC present with younger age of onset, different clinical features and are over-represented with the VV1 and MM2 subtypes of sporadic CJD. Further work is required to better understand the biochemical properties contributing to RT-QuIC negative results in these cases.
Existence and stability of shrinkers for the harmonic map heat flow in higher dimensions
Authors: Glogić Irfan , Kistner Sarah , Schörkhuber Birgit
Published: April 2024

We study singularity formation for the heat flow of harmonic maps from $$\mathbb {R}^d$$

R

d

. For each $$d \ge 4$$

d
≥
4

, we construct a compact, d-dimensional, rotationally symmetric target manifold that allows for the existence of a corotational self-similar shrinking solution (shortly shrinker) that represents a stable blowup mechanism for the corresponding Cauchy problem.
Chiral Symmetry and Nuclear Interactions
Authors: Epelbaum Evgeny
Published: April 2024

About 3 decades ago, Steven Weinberg came up with an idea of using the effective chiral Lagrangian to describe nuclear interactions, which has had a long-lasting impact on nuclear physics. Here, I will reflect on what has been learned since that time about the role of chiral symmetry in this context and discuss achievements and challenges in advancing chiral EFT into a precision tool for light nuclei.
Video-based exergaming versus conventional rehabilitation on balance in pediatric brain tumor survivors: a randomized clinical trial
Authors: Tanrıverdi Müberra , Mutluay Fatma Karantay , Çakιr Fatma Betül
Published: April 2024

Balance problems are widely reported in Pediatric Brain Tumor Survivors (PBTS) due to tumor localization and the side effects of medical treatment. This study investigates the effects of conventional versus video-based games exercise training (exergaming) on balance in PBTS. The present study was a randomized controlled trial. The study included 23 PBTS who were randomized to a Video-Based balance exergaming Group (VBG) or Conventional balance exercise training Group (CG). In both groups, the interventions were targeted to the balance function and balance exercise training was administered twice a week for 8 weeks. VBG exercised using selected Nintendo Wii Fit Plus® balance games while CG received a specially designed balance training using conventional physiotherapy methods. The primary outcome was the balance tests (Timed Up and Go and Nintendo® Wii™ Center of Gravity: COG), and the secondary outcomes were the functional tests (10-m walking, 2-min walking, 5-step climb/descent/times), and disease effect test (PedsQL Brain Tumor Module). The outcomes were assessed before and after the intervention. At baseline, no significant clinical and outcome assessment differences existed between both groups except for COG (p = 0.0495). After training, overall scores for balance, functional, disease effect tests significantly improved in VBG (p < 0.05) while progress observed in CG was not significant (p > 0.05). Video-based balance exergaming was found effective and more so than conventional balance exercise training in PBTS. Greater effectiveness of exergaming is thought to be due to increased motivation and effort of the children who are more attracted to gaming than conventional exercising. Exergaming could be beneficial both in clinical and home settings with physiotherapist supervision and may reduce the costs of treatment while improving their health-related quality of life.
Targeting nucleotide metabolic pathways in colorectal cancer by integrating scRNA-seq, spatial transcriptome, and bulk RNA-seq data
Authors: Zhao Songyun , Zhang Pengpeng , Niu Sen , Xie Jiaheng , Liu Yuankun , Liu Yuan , Zhao Ning , Cheng Chao , Lu Peihua
Published: April 2024

Background

Colorectal cancer is a malignant tumor of the digestive system originating from abnormal cell proliferation in the colon or rectum, often leading to gastrointestinal symptoms and severe health issues. Nucleotide metabolism, which encompasses the synthesis of DNA and RNA, is a pivotal cellular biochemical process that significantly impacts both the progression and therapeutic strategies of colorectal cancer

Methods

For single-cell RNA sequencing (scRNA-seq), five functions were employed to calculate scores related to nucleotide metabolism. Cell developmental trajectory analysis and intercellular interaction analysis were utilized to explore the metabolic characteristics and communication patterns of different epithelial cells. These findings were further validated using spatial transcriptome RNA sequencing (stRNA-seq). A risk model was constructed using expression profile data from TCGA and GEO cohorts to optimize clinical decision-making. Key nucleotide metabolism-related genes (NMRGs) were functionally validated by further in vitro experiments.

Results

In both scRNA-seq and stRNA-seq, colorectal cancer (CRC) exhibited unique cellular heterogeneity, with myeloid cells and epithelial cells in tumor samples displaying higher nucleotide metabolism scores. Analysis of intercellular communication revealed enhanced signaling pathways and ligand-receptor interactions between epithelial cells with high nucleotide metabolism and fibroblasts. Spatial transcriptome sequencing confirmed elevated nucleotide metabolism states in the core region of tumor tissue. After identifying differentially expressed NMRGs in epithelial cells, a risk prognostic model based on four genes effectively predicted overall survival and immunotherapy outcomes in patients. High-risk group patients exhibited an immunosuppressive microenvironment and relatively poorer prognosis and responses to chemotherapy and immunotherapy. Finally, based on data analysis and a series of cellular functional experiments, ACOX1 and CPT2 were identified as novel therapeutic targets for CRC.

Conclusion

In this study, a comprehensive analysis of NMRGs in CRC was conducted using a combination of single-cell sequencing, spatial transcriptome sequencing, and high-throughput data. The prognostic model constructed with NMRGs shows potential as a standalone prognostic marker for colorectal cancer patients and may significantly influence the development of personalized treatment approaches for CRC.
A MiR181/Sirtuin1 regulatory circuit modulates drug response in biliary cancers
Authors: Barbato Anna , Piscopo Fabiola , Salati Massimiliano , Pollastro Carla , Evangelista Lorenzo , Ferrante Luigi , Limongello Davide , Brillante Simona , Iuliano Antonella , Reggiani-Bonetti Luca , Salatiello Maria , Iaccarino Antonino , Pisapia Pasquale , Malapelle Umberto , Troncone Giancarlo , Indrieri Alessia , Dominici Massimo , Franco Brunella , Carotenuto Pietro
Published: April 2024

Despite recent advances, biliary tract cancer (BTC) remains one of the most lethal tumor worldwide due to late diagnosis, limited therapeutic strategies and resistance to conventional therapies. In recent years, high-throughput technologies have enabled extensive genome, and transcriptome sequencing unveiling, among others, the regulatory potential of microRNAs (miRNAs). Compelling evidence shown that miRNA are attractive therapeutic targets and promising candidates as biomarkers for various therapy-resistant tumors. The analysis of miRNA profile successfully identified miR-181c and -181d as significantly downregulated in BTC patients. Low miR-181c and -181d expression levels were correlated with worse prognosis and poor treatment efficacy. In fact, progression-free survival analysis indicated poor survival rates in miR-181c and -181d low expressing patients. The expression profile of miR-181c and -181d in BTC cell lines revealed that both miRNAs were dysregulated. Functional in vitro experiments in BTC cell lines showed that overexpression of miR-181c and -181d affected cell viability and increased sensitivity to chemotherapy compared to controls. In addition, by using bioinformatic tools we showed that the miR-181c/d functional role is determined by binding to their target SIRT1 (Sirtuin 1). Moreover, BTC patients expressing high levels of miR-181 and low SIRT1 shown an improved survival and treatment response. An integrative network analysis demonstrated that, miR-181/SIRT1 circuit had a regulatory effect on several important metabolic tumor-related processes. Our study demonstrated that miR-181c and -181d act as tumor suppressor miRNA in BTC, suggesting the potential use as therapeutic strategy in resistant cancers and as predictive biomarker in the precision medicine of BTC.
The prevalence of chronic obstructive pulmonary disease in patients with spondyloarthritis compared to the general population in the southernmost region of Sweden: a case–control study
Authors: Zamout Petros , Exarchou Sofia , Sharma Ankita , Turesson Carl
Published: April 2024

Spondyloarthritis (SpA) has been associated with comorbidities, e.g., cardiovascular disease. However, little is known about the relation between SpA and chronic obstructive pulmonary disease (COPD). The aim of the study was to compare the prevalence of COPD in SpA to the general population. Patients with prevalent SpA in Skåne, Sweden, on December 31, 2018, were identified based on diagnostic codes in a regional register on primary care, secondary outpatient care and inpatient care. Population-based controls (5 per SpA case) were matched for age, sex and municipality. The base case definition for COPD required at least two prior visits with a registered COPD diagnosis. Stricter definitions included dispensed prescriptions for COPD and a COPD diagnosis made by a specialist in lung medicine. The prevalence of COPD in patients with SpA and controls, overall and stratified by sex and age, and the corresponding prevalence ratios, were estimated. A total of 3571 patients with SpA (51% male, mean age 53 years) were compared to 17,855 matched controls. The prevalence of COPD in patients with SpA was 37.8/1000, with a prevalence ratio compared to controls of 1.03 (95% CI 0.85–1.24). There were no significant differences in COPD prevalence between patients with SpA and controls in men or women, in any of the age groups, or in analyses using stricter definitions of COPD. In this regional study including data from primary care, the prevalence of COPD was not increased in patients with SpA compared to the background population.
C1q/Tumor Necrosis Factor-Related Protein-9 Enhances Macrophage Cholesterol Efflux and Improves Reverse Cholesterol Transport via AMPK Activation
Authors: Song Xiaosu , Liu Gaizhen , Bin Yunfei , Bai Rui , Liang Bin , Yang Huiyu
Published: April 2024

Cholesterol efflux from foam cells in atherosclerotic plaques is crucial for reverse cholesterol transport (RCT), an important antiatherogenic event. ATP-binding cassette (ABC) transporters, ABCA1 and ABCG1, are key receptors in the cholesterol efflux pathway. C1q/tumor necrosis factor-related protein-9 (CTRP9) is a newly discovered adipokine and exhibits an atheroprotective activity. However, the role of CTRP9 in RCT still remains unknown. In this work, we investigated the effect of subcutaneous administration of CTRP9 protein on RCT and atherosclerotic lesion formation in ApoE−/− mice fed with a high-fat diet. CTRP9-dependent regulation of cholesterol efflux and ABC transporters in RAW 264.7 foam cells was determined. Our results showed that CTRP9 protein decreased atherosclerotic lesions, increased cholesterol efflux, and upregulated liver ABCA1 and ABCG1 expression in ApoE−/− mice. CTRP9 treatment dose-dependently increased mRNA and protein expression of ABCA1, ABCG1, and LXR-α in RAW 264.7 foam cells. Moreover, the expression and phosphorylation of AMPK was potentiated upon CTRP9 treatment. Notably, CTRP9-induced cholesterol efflux and upregulation of ABCA, ABCG1, and LXR-α were impaired when AMPK was knocked down. AMPK depletion restored cholesterol accumulation in CTRP9-treated RAW 264.7 cells. Taken together, subcutaneous injection is an effective novel delivery route for CTRP9 protein, and exogenous CTRP9 can facilitate cholesterol efflux and promote RCT in an animal model of atherosclerosis. The atheroprotective activity of CTRP9 is mediated through the activation of AMPK signaling.
Ethnic differences in metabolic syndrome in high-income countries: A systematic review and meta-analysis
Authors: Adjei Nicholas Kofi , Samkange-Zeeb Florence , Boakye Daniel , Saleem Maham , Christianson Lara , Kebede Mihiretu M. , Heise Thomas L. , Brand Tilman , Esan Oluwaseun B. , Taylor-Robinson David C. , Agyemang Charles , Zeeb Hajo
Published: April 2024

This review aimed to systematically quantify the differences in Metabolic Syndrome (MetS) prevalence across various ethnic groups in high-income countries by sex, and to evaluate the overall prevalence trends from 1996 to 2022. We conducted a systematic literature review using MEDLINE, Web of Science Core Collection, CINAHL, and the Cochrane Library, focusing on studies about MetS prevalence among ethnic groups in high-income countries. We pooled 23 studies that used NCEP-ATP III criteria and included 147,756 healthy participants aged 18 and above. We calculated pooled prevalence estimates and 95% confidence intervals (CI) using both fixed-effect and random-effect intercept logistic regression models. Data were analysed for 3 periods: 1996–2005, 2006–2009, and 2010–2021. The pooled prevalence of MetS in high-income countries, based on the NCEP-ATP III criteria, was 27.4% over the studied period, showing an increase from 24.2% in 1996–2005 to 31.9% in 2010–2021, with men and women having similar rates. When stratified by ethnicity and sex, ethnic minority women experienced the highest prevalence at 31.7%, while ethnic majority women had the lowest at 22.7%. Notably, MetS was more prevalent in ethnic minority women than men. Among ethnic minorities, women had a higher prevalence of MetS than men, and the difference was highest in Asians (about 15 percentage points). Among women, the prevalence of MetS was highest in Asians (41.2%) and lowest in Blacks/Africans (26.7%). Among men, it was highest in indigenous minority groups (34.3%) and lowest among in Blacks/Africans (19.8%). MetS is increasing at an alarming rate in high-income countries, particularly among ethnic minority women. The burden of MetS could be effectively reduced by tailoring interventions according to ethnic variations and risk profiles.
Identification and Pathogenicity of Species Isolated from Stored Potato Tubers Showing Symptoms of Dry Rot Disease
Authors: Kim Nam Sook , Hong Sae Jin , Won Heon Seop , Kim Byung Sup , Gwon Se Hwi
Published: April 2024

Disease arises during the storage of potatoes as a result of pathogens introduced during growing and harvest of the tubers. In this study, the causative fungi of domestic potato dry rot disease were identified, and their pathogenicity was confirmed. A total of 76 species were isolated from 93 potato necropods collected from samples inoculated with dry rot disease. These 76 isolates were identified as Fusarium boothii, F. circinatum, F. citricola, F. foetens, F. iranicum, F. longifundum, F. oxysporum, F. pseudoanthophilum, F. solani, Botryotinia ranunculi, Clonostachys rosea, and Humicola nigrescens. The average size of the inoculation site was ≥ 4.6 mm in F. oxysporum and F. solani, which were pathogenic to dry rot in potatoes but were not pathogenic compared to other strains up to 5 weeks in a 15 to 20 °C and 99% RH environment. The pathogenicity of F. foetens and F. pseudoanthophilum was related to a strong relationship by forming a single system with F. oxysporum. However, except for F. oxysporum and F. solani, these strains have not yet been reported to be associated with dry rot disease. Additionally, the length of the cross-section and longitudinal section of the potato damage symptom inoculated with C. rosea increased the most among all strains. This suggests that C. rosea is the dominant species involved in domestic potato dry rot disease. By contrast, there are no reports of the involvement of B. ranunculi and H. nigrescens in dry rot disease. Therefore, these strains can be seen as parasitic using potato sclerosis as nutrients in in vivo experiments through wounds and are not directly related to dry rot disease.
Gesundheitsförderung durch städtische Planung
Authors: Adami Tammo , Westenhöfer Joachim , Benneckenstein Astrid , Sinning Heidi , Bojahr Christian , Sibilis Arne , Tolg Boris
Published: April 2024

Hintergrund

Die Bedeutung gesundheitsfördernder Stadtplanung gewinnt angesichts der steigenden Urbanisierung und der hohen globalen Prävalenz nichtübertragbarer Krankheiten zunehmend an Relevanz. Wenngleich gesetzliche Vorgaben für die Berücksichtigung gesundheitlicher Aspekte in städtischen Planungsprozessen existieren, besteht Handlungsbedarf hinsichtlich einer gezielten Stärkung von gesundheitsfördernden Potenzialen.

Fragestellung

Der Beitrag beleuchtet wichtige stadtplanerische Schlüsselfaktoren und deren direkte Effekte, welche im Zuge einer gesundheitsfördernden Planung eine Rolle für die menschliche Gesundheit spielen. Nach einem Überblick über diese Faktoren werden daraus folgende Konsequenzen und Handlungsansätze dargestellt.

Ergebnisse

Stadtplanerische Schlüsselfaktoren können verschiedene Bereiche wie Bewegungsaktivität, Ernährung, Hitze, Luftverschmutzung, Lärm oder Stressempfinden positiv beeinflussen, was mit Risikosenkungen und positiven Auswirkungen für eine Reihe von nichtübertragbaren Krankheiten wie Herz-Kreislauf-Erkrankungen, Atemwegserkrankungen oder Diabetes einhergeht.

Schlussfolgerung

Im Kontext der Prävention nichtübertragbarer Krankheiten ist zukünftig eine vermehrte Berücksichtigung der Gestaltung der städtebaulichen Umgebung erforderlich. Von Bedeutung ist eine stärker interdisziplinäre Zusammenarbeit zwischen Akteur*innen aus der Stadtplanung und der öffentlichen Gesundheitsdienste. Die Integration von Gesundheitsfolgenabschätzungen in Stadtentwicklungsprozesse könnte dazu beitragen, die gesundheitsförderlichen Potenziale von stadtplanerischen Maßnahmen besser zu erkennen und zu nutzen.
Advances in Radionuclide Therapies for Patients with Neuro-endocrine Tumors
Authors: Hoogenkamp Denise S. , de Wit–van der Veen Linda J. , Huizing Daphne M. V. , Tesselaar Margot E. T. , van Leeuwaarde Rachel S. , Stokkel Marcel P. M. , Lam Marnix G. E. H. , Braat Arthur J. A. T.
Published: April 2024

Purpose of Review

To provide insights into the role of peptide receptor radionuclide therapy (PRRT) in patients with advanced neuroendocrine tumors (NET) and an overview of possible strategies to combine PRRT with locoregional and systemic anticancer treatments.

Recent Findings

Research on combining PRRT with other treatments encompasses a wide variety or treatments, both local (transarterial radioembolization) and systemic therapies, chemotherapy (i.e., capecitabine and temozolomide), targeted therapies (i.e., olaparib, everolimus, and sunitinib), and immunotherapies (e.g., nivolumab and pembrolizumab). Furthermore, PRRT shows promising first results as a treatment prior to surgery.

There is great demand to enhance the efficacy of PRRT through combination with other anticancer treatments. While research in this area is currently limited, the field is rapidly evolving with numerous ongoing clinical trials aiming to address this need and explore novel therapeutic combinations.
Surjective and closed range differentiation operator
Authors: Mengestie Tesfa
Published: April 2024

We identify Fock-type spaces $$\mathcal {F}_{(m,p)}$$

F

(
m
,
p
)

on which the differentiation operator D has closed range. We prove that D has closed range only if it is surjective, and this happens if and only if $$m=1$$

m
=
1

. Moreover, since the operator is unbounded on the classical Fock spaces, we consider the modified or the weighted composition–differentiation operator, $$D_{(u,\psi ,n)} f= u\cdot \big ( f^{(n)}\circ \psi \big )$$

D

(
u
,
ψ
,
n
)

f
=
u
·

(

f

(
n
)

∘
ψ

)

, on these spaces and describe conditions under which the operator admits closed range, surjective, and order bounded structures.
Improved Plating Adhesion of Polyarylate Fibers via Supercritical CO2 and Impregnation of Slightly Soluble Oil on the Fiber Surface
Authors: Sakai Tomoki , Tabata Isao , Hori Teruo , Hirogaki Kazumasa
Published: April 2024

There is a growing demand for conductive fibers with high bending resistance, particularly for applications, such as smart textiles and robot arms. The amount of fiber for such applications can be reduced using high-performance fibers with high tensile properties, such as polyaramid and polyarylate Vectran®). However, because such fibers are crystalline with rigid molecular structures, they poorly adhere to plated films; thus, the plated fibers exhibit poor bending fatigue resistance. To solve this problem, in this study, we expanded polyarylate fiber using supercritical CO2 (ScCO2) and impregnated it with a metal complex (palladium acetate), which acts as a catalyst for electroless plating to induce an anchoring effect. However, because polyarylate fiber has an extremely low polarity, it is difficult to uniformly impregnate it with many metal complexes, even with ScCO2. Generally, an organic solvent is added to tune the polarity of supercritical CO2; however, the metal complex penetrates the fiber, thereby reducing the amount of metal complex near the fiber surface. Therefore, we tuned the polarity of the surface by applying various oils to the fiber surface. The sample electroplated in ScCO2 with oil applied to its surface showed the highest bending fatigue resistance, followed by that treated in ScCO2 without oil, and the sample treated in an aqueous solution showed the lowest. Furthermore, we measured the interfacial adhesion strength of the samples using the microdroplet method, and the same trend was observed.
Having Different Dialog Roles in Telecommunication by Using Two Teleoperated Robots Reduces an Operator’s Guilt
Authors: Nozawa Reina , Sakai Kazuki , Kawata Megumi , Ishiguro Hiroshi , Yoshikawa Yuichiro
Published: April 2024

In recent years, applications of social robots as the operator’s avatar have been widely studied for remote conversation with rich nonverbal information. Having another side-participant robot beside the avatar robot of the operator was found to be effective for providing long-lasting backchannels to the interlocutor. The side-participant robot is also expected to play a role in assisting human participation in multiparty conversations. However, such a focus has not been applied to remote conversations with multiple robots. Here, we propose a multiple-robot telecommunication system with which the operator can use a side-participant robot to assist conversation that is developed by the operator through the main speaker robot to verify its effectiveness. In the laboratory experiment where the subjects were made to feel stressed by being forced to provide rude questions to the interlocutor, the proposed system was shown to reduce guilt and to improve the overall mood of operators. The result encourages the application of a multi robot remote conversation system to allow the user to participate in remote conversations with less anxiety of potential failure in maintaining the conversation.
Advances in Food Processing Through Radio Frequency Technology: Applications in Pest Control, Microbial and Enzymatic Inactivation
Authors: Costa Josiel Martins , Marra Francesco
Published: April 2024

Foodborne illnesses occur due to contamination by pathogenic microorganisms. Therefore, decontaminating food is vital before marketing and circulation. Radio frequency (RF) heating stands out in several branches of industry, mainly food processing, as an alternative method to conventional pasteurization which takes long process times and overheating. RF heating functions without relying on heat conduction. It generates internal heat by inducing the rotation of polar molecules and the motion of ions. The advantages of dielectric heating with greater wave penetration include rapid, uniform and volumetric heating, presenting high energy efficiency. Furthermore, it is an effective, validated method for eliminating pathogens in agricultural products and is free from chemical residues. Although many reviews have discussed this technology, few reviews have covered the research trends in this field in the recent years, during which the number of studies discussing RF treatment of foods have increased. Therefore, this review focuses on the RF applications in the food industry for pest control, microbial and enzymatic inactivation of solid, liquid, and powdered foods in the last five years. Besides covering the fundamental aspects of RF technology, we also examine its benefits and drawbacks, address the challenges it presents, and explore future prospects

Graphical Abstract
The﻿ Picocoraciades (hoopoes, rollers, woodpeckers, and allies) from the early Eocene London Clay of Walton-on-the-Naze
Authors: Mayr Gerald , Kitchener Andrew C.
Published: April 2024

We describe upupiform, coraciiform, and possible piciform birds from the early Eocene London Clay of Walton-on-the-Naze (Essex, UK). The material includes partial skeletons of a new species of a small upupiform bird, Waltonirrisor tendringensis, gen. et sp. nov., which is the earliest known representative of the Upupiformes. Three very similar species of stem group rollers are assigned to Laputavis robusta, Septencoracias morsensis, and S. simillimus, sp. nov. These species only differ in minor features, which raises the possibility that the taxon Sepencoracias Bourdon, 2016﻿ is a junior synonym of Laputavis Dyke, 2001﻿. A smaller stem group roller from Walton-on-the-Naze resembles the North American primobucconid species Primobucco mcgrewi. We also describe two species of a new genus-level taxon, Pristineanis, gen. nov., which shows close affinities to the North American “Neanis” kistneri and may be a stem group representative of the Piciformes. In many aspects of their postcranial osteology, the stem group Coracii from Walton-on-the-Naze, as well as the new taxon Pristineanis, resemble coeval Trogoniformes from this fossil site. Because trogons are the extant sister taxon of the Picocoraciades – the clade including the Upupiformes, Coraciiformes, and Piciformes –, the shared similarities are likely to be plesiomorphic for this latter clade. Early Cenozoic representatives of the Upupiformes and Coraciiformes were much smaller than their extant relatives, which suggests that the Picocoraciades are an avian example of Cope’s Rule that postulates a tendency for size increase in evolutionary lineages over time.
Analysis of fractures generated by faults at micro- and macro-scale and the influence on the secondary permeability: application to the Nevado del Ruiz area (Colombia)
Authors: Urrea Daniela , Moreno David , Lopez-Sanchez Jacqueline , Blessent Daniela
Published: April 2024

This research contributes to the knowledge of the geothermal area of the Nevado del Ruiz Volcano (Colombia) by analyzing the secondary permeability and connectivity of fractures at microstructural and macrostructural level. Although the Nevado del Ruiz Volcano (NRV) area has had geothermal exploration studies for power generation since 1968, there is still no exploitation of its geothermal resources. The NRV geothermal reservoir is characterized by a low primary permeability and the presence of several geological faults crossing a tectonically active and complex region. The analysis was performed comparing a zone affected by intense faulting with another one characterized by the same lithology, but with less influence of faulting and located further from the volcano. Fractures were characterized at outcrops with the window sampling method, and petrographic analysis was performed to confirm the mineralogy of samples collected. At the microstructural scale it was found that faulting does not necessarily influence the interconnectivity of fractures, but it does influence their intensity, quantity, and strike. To analyze the influence of fractures on groundwater flow, it is suggested to consider three main aspects: secondary permeability, connectivity, and fracture intensity. The lithology of major geothermal interest in the NVR area (Pes) presented greater connectivity and fracture intensity, which, combined with the high foliation observed in field, increase its effective permeability. The secondary permeability of different lithologies in the NRV area ranged between 1.15 × 10–6 and 10.32 × 10–7 m2. Most of the hot springs were in areas of high macrostructural connectivity, supporting the idea that groundwater flow is dominated by the secondary permeability of rocks. Estimation of the secondary permeability and identification of areas of high fracturing and connectivity, contributes to the understanding of the NRV geothermal area, which is a key aspect when drilling for successful well production. The methodology presented is useful in the initial exploration phase in fractured geothermal reservoirs.
Power quality assessment and compliance of grid-connected PV systems in low voltage networks using microinverters
Authors: Atsu D. , Seres I. , Farkas I.
Published: April 2024

Solar PV has experienced unprecedented growth in the last decade, with the most significant additions being utility-scale solar PV. The role of grid inverters is very critical in feeding power from distributed sources into the grid. With the increasing growth of grid-tied solar PV systems (both rooftop and large-scale), the awareness of power quality issues has risen with new regulations and standards to ensure the stability of the power grid. The power quality of microinverters has been investigated under steady solar irradiation and PV power source and also under real outdoor conditions in compliance with the accepted solar PV integration requirements. The current total harmonic distortion (THD) measured for the studied microinverter under outdoor conditions far exceeded the current THD for the study under steady indoor conditions and was beyond the accepted standard. However, the voltage THD outputs for the two studied cases were in good agreement with the grid codes. The voltage and current THD for the 400 Wm−2(60 Wp) and the 1000 Wm−2(146 Wp) scenarios under the steady solar irradiation (solar PV power) were 2.24%, 13%, and 2.27, 6.93%, respectively. The voltage and current THDs for the outdoor study were 2.03% and 14.28% for Solarex (pc-Si module), 1.94%, and 27.43% for Juta (mc-Si modules), and 1.97% and 33.6% for Dunasolar (a-Si glass module). Results showed a strong correlation between the intermittence of solar radiation and the current THD. 67%, 54%, and 37% of the recorded power factor for Dunasolar, Juta, and Solarex modules, respectively, exceeded the limits prescribed by the standards.
Adsorption of methyl blue, dichromate, and copper on ettringite under various pH values
Authors: Mariska Sarah , Lin Jr-Lin , Tuyet Truong Thi Anh , Hai Nguyen Duy , Chao Huan-Ping
Published: April 2024

Ettringite is a hydrous calcium aluminum sulfate mineral present in cement. In this study, ettringite was synthesized via co-precipitation to remove methyl blue, dichromate, and copper ions from solutions with various pH values. The synthesized ettringite was characterized using scanning electron microscopy, X-ray photoelectron spectrometry, Fourier transform infrared spectroscopy, zeta potential analysis, and the Brunauer–Emmett–Teller method. Equilibrium adsorption experiments were performed using methyl blue and dichromate at pH values ranging from 5 to 11. To avoid precipitation, equilibrium adsorption experiments were performed on copper ions in solutions with pH values of 3, 4, and 5. The adsorption kinetics experiments for each contaminant were performed at pH 5. The results showed that ettringite was successfully synthesized, and calcite might have precipitated during the synthesis process. The point of zero charge was at pH 8.6. The maximum adsorption capacities for methyl blue, dichromate, and copper ions at pH 5 were 406, 321, and 365 mg/g, respectively. The adsorption kinetics fitted the pseudo-second-order model well. The properties of the contaminants affect their equilibrium and rate constants. Ion exchange is regarded as the primary adsorption mechanism, whereas the other mechanisms include complexation, hydrogen bonding, surface precipitation, π-interaction, and van der Waals forces. This study revealed a new adsorbent, ettringite, for the removal of contaminants from wastewater, which is a promising alternative adsorbent that can be used under specific conditions.
Microalgae for freshwater arsenic bioremediation: examining cellular toxicity, bioconcentration factor and eluding an alternative arsenic detoxification pathway
Authors: Tang Wenn Wenn , Foo Su Chern
Published: April 2024

Microalgae are photoautotrophic organisms in freshwater systems known to uptake and bioremediate arsenic, a heavy metal. In this study, we compared the growth and arsenic uptake of two microalgae strains, Nostoc and Chlorella, to determine their suitability for arsenic bioremediation. As compared to the control, our results showed that treatment with As (III) enhanced the Nostoc growth by approximately 15% when grown in the absence of phosphate. The highest bioconcentration factor of Nostoc at this treatment was 1463.6, whereas 0.10 mg L−1 As (V) treatment improved the Chlorella growth by 25%, in the presence of phosphate. However, arsenic uptake reduced from 175.7 to 32.3 throughout the cultivation period for Chlorella. This suggests that Nostoc has an upper advantage in the bioremediation of arsenic as compared to the Chlorella strain. To gain insights into the potential of Nostoc in arsenic bioremediation, we further conducted SEM analysis on the vegetative cell surface. The SEM results showed that As (III) disrupted the Nostoc vegetative cell surface and structure. Further to this, pathway analysis and polymerase chain reaction (PCR) were conducted to identify the potential arsenic pathway regulated by Nostoc. The primary As (III)-related pathways elucidated include the arsA transporter and arsD complex that require ATP and As (III) methylation to S-adenosylmethionine. The phosphate deficiency condition resulting in the inability to generate ATP caused As (III) could not be excreted from the Nostoc cells, potentially contributing to the high arsenic concentration accumulated under phosphate-depleted conditions. These insights contribute to understanding the efficacy of microalgae strains in freshwater arsenic bioremediation.
Delayed gastric emptying after pancreatoduodenectomy: an analysis of risk factors
Authors: Sabogal Juan Carlos , Conde Monroy Danny , Rey Chaves Carlos Eduardo , Ayala Daniela , González Juliana
Published: April 2024

Background

Delayed gastric emptying (DGE) is a frequent complication after pancreatoduodenectomy. Preoperative factors are limited and controversial. This study aims to identify associated factors related to this complication in the Colombian population.

Methods

A retrospective review of a prospectively collected database was conducted. All patients over 18 years of age who underwent pancreaticoduodenectomy were included. Associations with DGE syndrome were evaluated with logistic regression analysis, Odds ratio, and b-coefficient were provided when appropriate.

Results

205 patients were included. Male patients constituted 54.15% (n = 111). 53 patients (25.85%) were diagnosed with DGE syndrome. Smoking habit (OR 17.58 p 0.00 95% CI 7.62–40.51), hydromorphone use > 0.6 mg/daily (OR 11.04 p 0.03 95% CI 1.26–96.66), bilirubin levels > 6 mg/dL (OR 2.51 p 0.02 95% CI 1.12–5.61), and pancreatic fistula type B (OR 2.72 p 0.02 CI 1.74–10.00).

Discussion

Smoking history, opioid use (hydromorphone > 0.6 mg/Daily), type B pancreatic fistula, and bilirubin levels > 6 mg/dL should be considered as risk factors for DGE.
Embedding the free topological group $$F(X^n)$$ into F(X)
Authors: Leiderman Arkady G. , Tkachenko Mikhail G.
Published: April 2024

In 1976, Nickolas showed that for each natural n, the free topological group $$F(X^n)$$

F
(

X
n

)

is topologically isomorphic to a subgroup of F(X) provided X is a compact space or, more generally, a $$k_{\omega }$$

k
ω

-space. We complement the Nickolas’ embedding theorem by showing that it remains true for every topological space X such that all finite powers of X are pseudocompact. For example, all pseudocompact k-spaces enjoy this property. Also, we extend the embedding theorem to the class of $$NC_\omega $$

N

C
ω

-spaces that includes, in particular, the $$k_\omega $$

k
ω

-spaces and the well-ordered spaces of ordinals $$[0, \alpha )$$

[
0
,
α
)

, for every ordinal $$\alpha $$
α
. Our results are quite sharp because we present a first example of a Tychonoff space Z such that F(Z) does not contain an isomorphic copy of the group $$F(Z^2)$$

F
(

Z
2

)

. In addition, our space Z is countably compact, separable, and its square $$Z^2$$

Z
2

is not pseudocompact.