bluuebunny/crossref_metadata_2025 huggingface dataset:
Acute Effects o Foot Orthosis on Lower Limb Joint Angular Velocities During Normal Gait
Authors:   Department of Sport Management and Biomechanics, Faculty of Educational Science and Psychology, University of Mohaghegh Ardabili, Ardabil, Iran., Jafarnezhadgero Amir Ali , Madadi-Shad Morteza ,   Department of Sport Biomechanics, Faculty of Sports Sciences, Bu-Ali Sina University, Hamedan, Iran., Momen Hamid Reza ,   Department of Sports Physiology, Faculty of Sports Sciences, University of Tehran, Tehran, Iran., Hanifeh Mohammad Bagher ,   Department of Kinesiology, Farhangian University, Tehran, Iran.
Published: October 2022

Background and Aims The use of arch support foot orthoses is becoming quite widesprea in the management of foot pathologies. This study examined how lower limb joint angular velocities change with wearing arch support foot orthoses. Methods In this semi-experimental study, 20 healthy male volunteers (age: 34.2±8.9 years; height: 173.5±5.4 cm; mass: 76.3±13.5 kg; and BMI: 25.7±9.1 kg/m2) participated. The participants completed ten walking trials at a self-selected walking speed while 3-dimensional kinematic data of their ankle, knee, and hip joints were collected. Paired samples t-test was used for comparing two conditions: shod with no orthoses and shod with arch support foot orthoses. Results The use of arch support foot orthoses decreased joint angular velocity for the hip extension (P=0.000) and ankle dorsiflexion (P=0.02) compared to walking without orthoses. However, results revealed no significant differences in knee joint angular velocity values between both walking conditions (P=0.16). Conclusion We concluded that arch support foot orthoses can decrease ankle and hip joint angular velocities. The use of arch-support foot orthoses reduces the risk of overuse injuries by decreasing lower limb joint angular velocities.
Comparison of Pelvic Floor Muscle Function in Women With Stress Urinary Incontinence and Overactive Bladder and Healthy Women
Authors:   Department of Physiotherapy, Faculty of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Kasaeian Delara , Dehghan Manshadi Farideh ,   Department of Physiotherapy, Faculty of Rehabilitation, Shahid Beheshti University of Medical Sciences, Tehran, Iran., Shokouhi Nasim ,   Department of Gynecology, Yas Educational Medical Hospital, Tehran University of Medical Sciences, Tehran, Iran., Miri Elahe ,   Department of Gynecology, Imam Khomeini Educational Medical Hospital, Tehran University of Medical Sciences, Tehran, Iran., Tabatabaee Seyed Mehdi ,   Research Center Physiotherapy, Faculty of Rehabilitation, Shahid Beheshti University of Medical Science, Tehran, Iran.
Published: October 2022

Background and Aims Urinary incontinence (UI) has been known as one of the clinical manifestations of pelvic floor muscle (PFM) instability; however, limited research has been published on PFM function in patients with different types of UI. This study aimed to compare the PFM function of the continent women and women with Stress urinary incontinence (SUI) and overactive bladder (OAB). Methods This cross-sectional comparative study was performed on 30 women, 10 continents, 10 SUI, and 10 OAB, with a mean age of 42.67±4.77 years. PFM function was assessed using manual muscle testing, a perimeter, and surface electromyography. Data analysis was performed using SPSS software and the level of significance was considered as P≥0. 05. Results There was no significant difference in the PFM function, strength, and electromyographic activity between SUI and OAB patients. However, it decreased in both groups compared to the healthy group (P=0.001). Also, a strong correlation was found between clinical examination, a perimeter, and electromyography (r=0.82, P=0.0001). Conclusion This study revealed that the PFM function was impaired in both groups of women with SUI and OAB. Also, both manual examination and the perimeter can be used as clinical methods in evaluating PFM function.
The Effect of Resistance Training With Electrical Muscle Stimulation on Atrogin-1 and Muscle Ring Finger-1 in Elite Male Athletes After Anterior Cruciate Ligament Surgery
Authors:   Department of Sport Physiology, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, North Khorasan Province, Iran., Alavi Abouzar , Rezaeian Najmeh ,   Department of Sport Physiology, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, North Khorasan Province, Iran., Ganji Reza ,   Department of Orthopedic Surgery, Faculty of Medicine, North Khorasan University of Medical Sciences, Bojnurd, North Khorasan Province, Iran., Yaghoubi Ali ,   Department of Sport Physiology, Faculty of Humanities, Bojnourd Branch, Islamic Azad University, Bojnourd, North Khorasan Province, Iran.
Published: October 2022

Background and Aims The cellular mechanisms preventing muscle atrophy after Anterior Cruciate Ligament (ACL) regeneration are not well understood. The aim of the present study was to evaluate the effect of resistance training combined with electrical muscle stimulation on serum levels of atrogin-1 and muscle RING finger-1 (MuRF1) in elite athletes following ACL surgery. Methods Among the elite athletes of Razavi Khorasan Province, 20 athletes voluntarily participated in the study and were divided into two groups (ten cases each), including 1) resistance training- electrical muscle stimulation (RT-EMS), and 2) resistance training (RT). The subjects in both groups performed 2-4 sets of resistance exercises (knee extension machine, squat, and knee flexion machines) at an intensity of 30-70% of ten repetitions for 12 weeks. The subjects in the RT-EMS group performed the exercises in combination with electrical stimulation at 35-70 Hz. Blood samples were collected from all subjects before and 48 hours after the last training session to measure atrogin-1 and MuRF1 levels. Analysis of covariance (ANCOVA) and paired t-test were used to compare between- and within-group changes, respectively, and a P<0.05 was considered significant. Results The results showed that 12 weeks of resistance training- electrical muscle stimulation significantly decreased serum levels of atrogin 1 (P=0.013) and MuRF1 (P=0.008) in the post-test compared to the pre-test. In addition, the between-groups comparison showed a significant difference in atrogin 1 levels between the RT-EMS and RT groups (P=0.047). Conclusion It can be suggested that resistance training in combination with electrical muscle stimulation is associated with lower levels of muscular atrophy proteins, such as atrogin-1 and MuRF1, and therefore, can be more effective than resistance training alone.
Simultaneous Effect of Aerobic Training and Resveratrol Supplementation on Interleukin-6 Serum Levels in Women With Type 2 Diabetes
Authors:   Department of Physical Education and Sport Science, Faculty of Education and Psycology, University of Mohaghegh Ardabili, Ardabil,Iran., Yazdkhasti Ensiyeh , Seifi-SkiShahr Farnaz ,   Department of Physical Education and Sport Science, Faculty of Education and Psycology, University of Mohaghegh Ardabili, Ardabil,Iran., Ebrahim Bahram Mohammad ,   Department of Physical Education and Sport Science, Faculty of Education and Psycology, University of Mohaghegh Ardabili, Ardabil,Iran.
Published: October 2022

Background and Aims Diabetes pathogenesis is driven by a complex network of pro-inflammatory cells and cytokines, of which interleukin-6 (IL-6) plays a key role in the chronic inflammation associated with type 2 diabetes. The use of supplements and plant extracts and exercise to treat type 2 diabetes is common today. The aim of this study was to evaluate the simultaneous effect of aerobic training and resveratrol supplementation on IL-6serum levels in women with type 2 diabetes. Methods This study was a quasi-experimental study with a pre-test-post-test design and a control group, in which 24 women with type 2 diabetes were randomly assigned to three equal groups of supplement (age 55.25±5.11 years), training+supplement (400 mg resveratrol) (age 54.62±7.22 years), and control (age 52.25±8.60 years). The subjects practiced for six weeks and every week for three days for 40-60 min and at a heart rate of 45-65. Data analysis was performed using analysis of covariance and correlated t-test at the significant level of <0.05. Results The results showed that after the intervention, IL-6 serum levels in the aerobic training + supplement group (P=0.01) had a significant decrease compared to the supplement and control groups. Examination of intergroup changes shows that there was a significant difference in IL-6 levels between the training + supplement group and the supplement group (P=0.002, f=1.56). Also, the results of the Tukey post hoc test showed that there was a significant difference between the control group and the training + supplement group (P=0.003) and between the supplement group and the training+supplement group in IL-6 levels (P=0.031). Conclusion Based on the findings of the present study, it seems that concomitant use of resveratrol supplementation and aerobic training can reduce the levels of IL-6 and the supplement have anti-inflammatory and protective effects in women with type 2 diabetes.
Packaging Framework System Under International Trade Rules
Authors:   The Institute of Management and Economy Research, Du Xue-fei , Cho Hyun-sook
Published: October 2022

Purpose - The purpose of this study was to expound the packaging framework system(PFS) under international trade rules. Design/methodology/approach - This study analyzed packaging framework system and packaging regulations and technical standards in international regulations and major countries and classified these in some standards Findings - First, the study provides packaging provisions associated with packaging regulations and technical standards (PRTS). Then, the basis of PFS in international trade rules was proposed; it is believed that the PFS was composed of packaging legal system in WTO institutional framework (WTO-PLS), international organization packaging standard system (IO-PSS) and major countries or regions packaging regulatory system (MCR-PRS). Secondly, this paper expounded relations and legal characteristics of the three packaging systems. Finally, This study investigated PRTS coverage under technical barriers to trade (TBT) and Sanitary and Phytosanitary measures (SPS). Research implications or Originality The regulations associated with PRTS have played a key role in challenges to merchandise trade in international trade. This study has significance in classifying packaging related reticulations into several criteria unlike previous studies. Therefore it is hope that this study can provide a supplementary document for the existing research of PRTS.
Effects of Perceived Control upon Role Performances among Healthcare Service Customers
Authors:   The Institute of Management and Economy Research, Lee Jung-Ki
Published: October 2022

Purpose - The purpose of this study is to examine whether a psychological concept enhances healthcare users’ service experience. Specifically, the study proposes and empirically examines a model of perceived control in which the user’s sense of control is postulated as exerting positive influences upon his/her motivation, self-efficacy associated with his/her role as a patient, and satisfaction with his/her medical service experience. Methodology - Data were collected by a professional research company, using an online survey method. Participants of the study included adults nineteen years or older who had visited a medical service institute at least once during the previous one-year period. For the test of the research hypotheses, structural equation modeling using AMOS was used. Findings - Findings of this study denote a unique insight into the users’ comprehension of medical service experiences and their behaviors. First, the concept of perceived control is identified as a factor that enhances the quality of individuals’ medical service experiences. A sense of control directly influences medical users’ self-efficacy to comply with doctor’s recommendations, their motivation to comply with doctor’s recommendations, and their satisfaction with the medical service experience. Second, one’s perceived self-efficacy is found to exert positive influences upon both motivation and satisfaction. Third, one’s motivation to comply with the doctor’s recommendation is found to exert a positive influence upon one’s satisfaction. Additionally, perceived control is found to exert an indirect influence upon medical service users’ satisfaction through the mediation of both self-efficacy and motivation. Research Implications - The findings of the study support the notion that perception of control among medial service users enhances their service experience as patients. The main thrust of this study suggests that it is necessary for healthcare practitioners to consider implementing service encounter strategies that purposefully enhance the sense of control among their patients. The identification of significant inter-relationships among perceived control, motivation, self-efficacy, and satisfaction among medical service customers should also serve as a meaningful seed for further research pursuits.
A Study on Service Improvement Plan of Technology Trade Platform
Authors:   The Institute of Management and Economy Research, Cho Gyu-Dae , Hong Jae-Bum
Published: October 2022

Purpose - The domestic technology trading market is composed of a technology trading platform with the participation of technology trading institutions. The institution that operates the technology trading platform provides various support for technology transaction. The purpose of this study is to suggest improvement plans through analysis of the services provided by the technology trading platform. Design/methodology/approach TA model was built based on existing research and the importance and satisfaction of each evaluation item of the model were identified through the hierarchical analysis process and expert opinion gathering. Then importance-satisfaction correlation analysis was applied. Findings - As a result of analyzing the importance of the technology trading platform, supply technology information, technology value evaluation, and demand technology information are in order. Technology marketing and demand technology information are areas that require focus management and there are differences according to experience and low-skilled people suggest the need to improve technology value evaluation service. Research implications or Originality - This study is significant in that it evaluated the operational performance of a technology trading platform that had not been addressed for 15 years and suggested improvement measures. Initially a series of technology transaction processes such as technology value evaluation technology matching and technology commercialization support were expanded from simple information on previous technology and this study includes these changes.
An Analysis on Regional Ripple Effects of the Sale and Chenosei Prices of the Apartments: A GVAR Approach
Authors:   The Institute of Management and Economy Research, Yoon Jai-Hyung
Published: October 2022

We analyze the regional ripple effects of both the sale prices and cheonsei prices using the global VAR(GVAR) model. The interest rate shock causes the regional sale prices to fall. Moreover, the greatest responses to the shock are those of Gangnam-gu, etc. because of there were many transactions for investment purpose. When interest rate rose, the cheonsei price in Gangnam-gu reacted greatly. Conversely, if interest rates fall, the cheonsei demand to live in Gangnam-gu increases. Furthermore, the response of sale price to the interest rate shock are greater than those of the cheonsei prices. Whereas, a positive shock on the sale price in Gangnam-gu increases the sale price there. It also raises the sale prices of the surrounding area in a similar pattern. The shock on the sale price in Gangnam-gu also increases the cheonsei price in Gangnam-gu. In addition, an increase in the sale price in Gangnam-gu leads to increases of cheonsei prices in other regions. Therefore, the recent rise of the base rate can negatively affect the sale prices, and thus a decrease in the sale price spreads to the surrounding areas. Accordingly, it is time for policy alternatives to make a soft landing in sale prices.
The Effects of Food Delivery and Single-Person Household on Municipal Solid Waste Generation: Focus on the COVID-19 Period
Authors:   The Institute of Management and Economy Research, Kim Hyung-Gun
Published: October 2022

Purpose - This study empirically analyzes the effects of food delivery service use frequency and the proportion of single-person households on the generation of MSW (Municipal Solid Waste). Additionally, the study analyzes MSW increase during the COVID-19 period. Design/methodology/approach - The study uses annual information on MSW and related characteristics of 228 Si, Gun, and Gu, which are administrative districts of Korea, from 2015 to 2020. Panel fixed effect model is employed for estimations. Findings - The study finds that food delivery and single-person household have significant effects only on recyclable and standard garbage bag MSW, respectively, not on all produce types of MSW. Additionally, it is estimated that, during the COVID-19 period, the increasing effect of food delivery is intensified while single-person households diminish its increasing effect. Lastly, the study confirms that the marginal effect on the increasing effect of MSW generation by the number of household members. Research implications or Originality - The estimated results are expected to provide useful information for the related policies. In particular, it is necessary to focus more on recyclable MSW concerning the developing delivery culture, and regarding changes in the family structure, focus more on the number of household members than single-person households.
The Relationship between Local Residents’ Perceptions of Tourism, Attitudes and Support: The Case of a World Heritage Sites in Chengdu City, Sichuan, China
Authors:   The Institute of Management and Economy Research, Kim Sung-Bum , Kwon Ki-Joon
Published: October 2022

Purpose The purpose of this study was to investigate the structural relationship between residents’ positive and negative perceptions on tourism impact, attitudes and support for tourism development. It was also investigate the moderating effects of gender and residence status of local residents among the relationships. Design/methodology/approach The survey conducted for residents of Chengdu, Sichuan Province, China. A total of 520 samples were employed for the final analysis, and the collected data were performed using SPSS and AMOS. Findings It was found that the residents’ positive and negative perceptions on tourism impact had significant effects on the attitudes and support for tourism development. In addition, the gender and residence status of local residents showed a partial moderating effect among the relationships. Research implications The theoretical and practical implications are discussed.
Sobre a Legislação de Registro de Fitoterápicos
Authors: Tappin M. R. R. , Lucchetti L.
Published: October 2022

O aprimoramento do conhecimento científico e tecnológico referente aos fitoterápicos; paralela e indiretamente, tem ocasionado uma evolução da legislação para o registro de tais produtos, pelas autoridades de saúde. O presente artigo traz uma revisão dos processos legais para o registro de fitoterápico no Brasil, assim como de alguns casos de legislações estrangeiras sobre o tema.
1Este artigo é parte do trabalho do levantamento teórico realizado pelo autor para a sua Dissertação de Mestrado, emandamento no Programa de Pós-Graduação em Vigilância Sanitária, no Instituto Nacionalde Controle de Qualidade em Saúde, Fundação Oswaldo Cruz, INCQS, FIOCRUZ, Rio de Janeiro, sob a orientação dos Drs. Leonardo Luchetti e Antonio C. Siani.
Aspectos sobre Produtos Naturais na Descoberta de Novos Agentes Antitumorais e Antimutagênicos
Authors: Maciel M. A. M. , Gomes F. E. S. , Pinto A. C. , Cólus I. M. S. , Magalhães N. S. S. , Grynberg N. F. , Echevarria A.
Published: October 2022

O presente estudo traz um breve histórico sobre produtos naturais anticarcinogênicos, bem como aspectos relevantes de pesquisas quimiofarmacológicas onde agentes anticancerígenos são o alvo principal de investigações. Neste contexto, mostra uma abordagem geral sobre quimioterapia e mutagenicidade. Focaliza ainda, aspectos químicos e propriedades anticâncer e antimutagênica de uma das mais importantes plantas medicinais brasileiras da atualidade: Croton cajucara Benth, uma euforbiácea, muito utilizada na medicina popular da região Amazônica, de onde se isola a promissora substância trans-desidrocrotonina, cujo uso vem sendo difundido por todo o país, e que poderia representar uma substância a ser mais bem explorada como agente anticâncer. Sua incorporação em sistemas de liberação controlada também é abordada.
ЕКОНОМІКО-ТЕХНОЛОГІЧНЕ СТИМУЛЮВАННЯ ПРИРОДОЗБЕРЕЖЕННЯ
Authors: ПОЛІЩУК Віктор
Published: October 2022

Анотація. Метою статті є аналіз економічних та технологічних механізмів впливу на рівень процесів природозбереження з урахуванням динаміки розвитку економіки в глобальному світі. Пропонується вивчати і впроваджувати досвід країн ринкової економіки щодо формування сучасної та раціональної природоохоронної політики з використанням інноваційних інструментів екологізації та технологізації господарства. Проаналізовано низку вагомих показників, що характеризують динаміку транспортних надходжень та екологічних виплат в країнах Європейського союзу, та наведені перспективи масштабності використання відновлювальних джерел енергії та їх альтернативного впливу на розвиток світових енергетичних систем. Визначена концепція реалізації екологічних проектів та програм через зміну економічних і технологічних підходів, що суттєво впливають на рівень якості навколишнього природного середовища. Методологія дослідження базується на проведенні комплексного порівняльного аналізу модернізації екологічних податків та транспортних зборів за забруднення навколишнього середовища; застосований системний підхід, що визначає вплив економічних і технологічних важелів на розвиток «зеленої» економіки та виробництво і використання «чиcтих» транспортних засобів. Наукова новизна роботи включає створення багатовекторної концепції оцінки показників та використання економіко-технологічних і екологічно-природозбережувальних підходів в дослідженні проблематики природоохоронного спрямування. Висновки. Надважливим стимулом сталого розвитку країн світу є впровадження інноваційної еколого-економічної та технологічної політики, що має бути спрямована першочергово на збереження навколишнього природного середовища і раціональне використання природних ресурсів. Екологічний вектор фіскальної політики має бути спрямований на створення таких податкових інструментів, які стануть одним із гарантів ефективного впливу на природоохоронну проблематику. Важливо звернути увагу на необхідність росту екологічної ефективності використання фінансових та технологічних інструментів, які забезпечать можливість значно зменшити негативний вплив на екосистеми та стимулювати екологічне природоохоронне інвестування.
instrumento de apoyo técnico a las reformas de la Comisión Europea
Authors: Álvarez Suárez Marisa
Published: October 2022

La Comisión Europea creó en 2017 una herramienta que presta asistencia técnica a las Administraciones de los Estados para apoyarles en el diseño, la implementación y la evaluación de sus reformas estructurales. Este instrumento de apoyo técnico ha sido usado por todos los Estados miembros -incluido España- desde su inicio en múltiples áreas y en más de 1.400 proyectos distintos. En 2021 el instrumento se ha reformado para, entre otros objetivos, vincularlo a los Planes de Recuperación y Resiliencia. Las autoridades valoran, en general, muy favorablemente su uso, aunque se plantean posibles vías de mejora para incrementar su eficacia y utilidad.
Croacia se convertirá en el vigésimo Estado miembro de la UE en adoptar el euro el 1 de enero de 2023
Authors: Martínez Jerez Ana María
Published: October 2022

Menos de una década después de unirse a la UE, Croacia está lista para integrarse en la zona del euro el 1 de enero de 2023 gracias a los esfuerzos realizados por sus autoridades para cumplir con las condiciones exigidas. La introducción del euro traerá cambios significativos para la economía y los empresarios croatas. La economía croata se volverá más competitiva y resistente, con unos mercados financieros mejor integrados y más eficientes. En un contexto internacional de incertidumbre marcado por la agresión militar de Rusia contra Ucrania y las tensiones inflacionistas, la aplicación efectiva de las reformas y la inversión establecidas en el Plan de Recuperación y Resiliencia de Croacia le permitirán abordar los principales retos macroeconómicos e institucionales para lograr una convergencia sostenida.
Transcurridos veinte años desde la introducción de los primeros billetes y monedas, el euro se ha convertido en un símbolo de la integración europea.
Modern algorithms of geno-phenotypic diagnosis of tuberculosis in Ukraine
Authors: Zhurylo O.A. , Barbova A.I.
Published: October 2022

BACKGROUND. To ensure timely and accurate detection of tuberculosis (TB), including TB with multiple drug resistance in Ukraine, the document “Health Standards for TB” (Order of the Ministry of Health of Ukraine № 2161 of 06.10.2021), which the basis of laboratory diagnosis of TB is the use of modern molecular genetic methods and tested in the Central Reference Laboratory of Ukraine for microbiological diagnosis of TB.

RESULTS AND DISCUSSION. The article presents complex algorithms for the diagnosis and monitoring treatment of pulmonary TB using rapid molecular genetic methods. The basic principles and approaches to the diagnostic process, on which the domestic normative document is based, corresponds to those recommended by World Health Organization experts for the countries of the European region. When testing for TB, a molecular genetic test must be performed to detect the presence of Mycobacterium tuberculosis DNA in the diagnostic sample. Then (depending on the capabilities of the laboratory) one or another technology is used to detect mutations associated with the resistance of M. tuberculosis to the maximum possible range of AMBP I and II lines. After receiving the results of seeding in the automated system BACTEC MGIT, which is currently the gold standard for the study of drug sensitivity of M. tuberculosis to AMBP I and II lines, the treatment regimen is adjusted if necessary according to the phenotypic test of drug sensitivity.

CONCLUSIONS. According to the latest international guidelines for the diagnosis of TB, preference should be given to molecular genetic diagnostic tests and culture studies in liquid nutrient media. Microscopic and cultural studies are important and remain necessary to monitor treatment.
Antiviral activity of aminocaproic acid against SARS-CoV-2: review of the literature and results of the first experimental study
Authors: Chiaravalli J. , Verneuil A. , Osiichuk V. , Golyshkin D. , Dziublyk O.Ya. , Gumeniuk M.I. , Denysov O.S.
Published: October 2022

BACKGROUND. The SARS-CoV-2 pandemic has a significant impact on the global health care system, so effective treatments for coronavirus disease (COVID-19) are urgently needed. Nowadays, drug repurposing is widely considered for COVID-19 therapy; significant attention is paid to inhibitors of transmembrane serine proteases (TMPRSS2), which ensure the penetration of SARS-CoV-2 into the human cells and contribute to their infection. ε-aminocaproic acid (ACA), which has been used worldwide for many years to correct blood loss as a fibrinolysis inhibitor, is also known for its ability to block TMPRRS2. It is approved by the Ministry of Health of Ukraine for the treatment of influenza and acute respiratory viral infections.

OBJECTIVE. The aim of our study was to evaluate the antiviral effect of ACA in vitro by staining of SARS-CoV-2 viral antigen (spike protein) and by visual scoring of cytopathogenic effect (CPE).

RESULTS AND DISCUSSION. Using immunohistochemistry assay it was found that the mean value of EC50 for ACA on Caco-2 cells was 2.5 mg/ml and on Calu-3 cells – 17.3 mg/ml. Using CPE assay it was identified that the mean value of EC50 for ACA on Caco-2 cells was 6.4 mg/ml and on Calu-3 cells – 8.7 mg/ml. Additional analysis was shown that ACA has low cytotoxicity with CC50 values of >50 mg/ml on Caco-2 cells after 24h and 48h incubation and 37,57 and 41,29 mg/ml on Calu-3 cells after 24h and 48h incubation, respectively. Antiviral activity of ACA was detected when using non-toxic concentrations of the drug and did not depend on the time of introduction of ACA (before the introduction of the virus simultaneously with the pathogen after 1-hour incubation). ACA can be recommended for further in vivo studies on laboratory animals.
Chemotherapy-Response Monitoring of Breast Cancer Patients Using Quantitative Ultrasound-Based Intra-Tumour Heterogeneities
Authors: Sadeghi-Naini Ali , Sannachi Lakshmanan , Tadayyon Hadi , Tran William T. , Slodkowska Elzbieta , Trudeau Maureen , Gandhi Sonal , Pritchard Kathleen , Kolios Michael , J. Czarnota Gregory
Published: October 2022

Anti-cancer therapies including chemotherapy aim to induce tumour cell death. Cell death introduces alterations in cell morphology and tissue micro-structures that cause measurable changes in tissue echogenicity. This study investigated the effectiveness of quantitative ultrasound (QUS) parametric imaging to characterize intra-tumour heterogeneity and monitor the pathological response of breast cancer to chemotherapy in a large cohort of patients (n = 100). Results demonstrated that QUS imaging can non-invasively monitor pathological response and outcome of breast cancer patients to chemotherapy early following treatment initiation. Specifically, QUS biomarkers quantifying spatial heterogeneities in size, concentration and spacing of acoustic scatterers could predict treatment responses of patients with cross-validated accuracies of 82 ± 0.7%, 86 ± 0.7% and 85 ± 0.9% and areas under the receiver operating characteristic (ROC) curve of 0.75 ± 0.1, 0.80 ± 0.1 and 0.89 ± 0.1 at 1, 4 and 8 weeks after the start of treatment, respectively. The patients classified as responders and nonresponders using QUS biomarkers demonstrated significantly different survivals, in good agreement with clinical and pathological endpoints. The results form a basis for using early predictive information on survival-linked patient response to facilitate adapting standard anti-cancer treatments on an individual patient basis.
Intricate watershed characteristics and chemical properties govern methyl mercury concentrations within headwater streams of boreal forests in Ontario, Canada: a structural equation modelling approach - Markdown
Authors: Harrow - Lyle Tyler , Lam Wai Ying , Emilson Erik J. S. , Mackereth Robert , Mitchell Carl P.J. , Melles Stephanie
Published: October 2022

We use a structural equation modelling approach to show how watershed characteristics and stream chemistry drive concentrations of methyl mercury in 19 streams across the Dryden- Wabigoon Forest in Ontario, Canada. 
Nilai-Nilai Dakwah dalam Tradisi Upacara Pernikahan Nayuh
Authors: Hilmi Mustofa , Fabriar Silvia Riskha , Soleha Dena Walda
Published: October 2022

Penelitian ini bertujuan untuk mengetahui nilai-nilai dakwah dalam tradisi upacara pernikahan nayuh pada masyarakat adat Lampung Suku Saibatin Kabupaten Pesisir Barat. Jenis penelitian yang digunakan adalah kualitatif dengan pendekatan deskriptif. Teknik Analisis data menggunakan model Miles dan A. Michel Huberman dimana terdapat tiga tahapan yang harus dilakukan yakni reduksi data, penyajian data, dan penarikan kesimpulan atau verifikasi. Teknik pengumpulan data melalui observasi, wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa terdapat nilai-nilai dakwah dalam tradisi nayuh yakni nilai ibadah, nilai silaturahmi, nilai shadaqoh, nilai keikhlasan dan nilai kebersamaan. Kajian ini berperan penting sebagai sarana untuk menjaga integritas dan merawat keharmonisan serta persatuan atas khazanah budaya bangsa.
Principles Of Compassion In The World Religions For Coexistence Among Religions In The Perspective Of Karen Armstrong
Authors: Supriyanto Supriyanto
Published: October 2022

Abstract

Sociologically, the face of human life on this earth is pluralistic, not only in culture, language, ethnicity, customs, skin color and ethnicity, but also in aspects of religious beliefs. The problem is, the plurality of religious beliefs colored by clash after clash between various adherents of different religions. In modern history, there have been so many violent conflicts and acts of terrorism that have occurred in the name of faith in various parts of the world. Although various motives other than religion can be sought, the perpetrators of modern terrorism claim to be inspired and motivated by a certain understanding of religion. Karen Armstrong presents a brilliant offer to the conflict that must be sought for a common platform that is fundamental and lies at the heart of every tradition of the world's major religions such as Islam, Judaism, Christianity, Hindi, Buddhism, and Confucianism. Karen found a fundamental principle that could become a common platform among world religions, namely the principle of compassion. This article will discuss Karen Armstrong's thoughts on the principles of compassion in the world's religious traditions for inter-religious coexistence using a historical and philosophical critical approach in depth.

Keywords: Compassion, World religion, coexistence, Karen Armstrong

Abstrak

Secara sosiologis, wajah kehidupan umat manusia di muka bumi ini berbentuk pluralistik bukan hanya dalam budaya, bahasa, etnis, adat, warna kulit dan suku bangsa, melainkan juga dalam aspek keyakinan agama. Persoalannya, pluralitas keyakinan agama tersebut tidak jarang diwarnai dengan benturan demi benturan antara pelbagai penganut agama yang berbeda satu sama lain. Dalam sejarah modern ini, terdapat begitu banyak konflik kekerasan dan tindakan terorisme yang terjadi atas nama keyakinan diberbagai belahan dunia. Meskipun bisa dicari pelbagai motif-motif selain agama, para pelaku terorisme modern tersebut mengaku diilhami dan dimotivasi oleh pemahaman tertentu atas agama. Karen Armstrong menyuguhkan sebuah tawaran brilian terhadap konflik tersebut bahwa harus dicari sebuah common flatform (pijakan bersama) yang bersifat fundamental dan terletak dalam jantung setiap tradisi agama-agama besar dunia seperti Islam, Yahudi, Kristen, Hindi, Buddha, dan Kong Hu Cu. Karen menemukan sebuah prinsip fundamental yang bisa menjadi common flatform antar agama-agama dunia yakni prinsip belas kasih (compassion). Artikel ini akan mendiskusikan pemikiran Karen Armstrong tentang prinsip-prinsip belas kasih dalam tradisi agama-agama dunia bagi koeksistensi antar umat beragama dengan menggunakan pendekatan historis dan dan kritis filosofis secara mendalam.

Kata Kunci: Belas kasih, Agama dunia, koeksistensi, Karen Armstrong
Improvement of marketing management at the energy enterprise by internet marketing instruments on the example of JSK "Vinnitsiaoblenergo"
Authors: Buha N. , Havrylyuk A.
Published: October 2022

In the article the features of the activity of the Energy Enterprise in the context of reforming the electric power industry are defined, the organizational structure is analyzed and its main shortcomings are identified; the main financial indicators of the enterprise are analyzed; in which indicators there is a tendency to increase and decrease are determined, possible consequences from maintaining a negative trend in the future are provided; the external environment of the enterprise is characterized, its strategic business units are highlighted; the threats and opportunities available to the enterprise under the influence of the external environment are considered. Based on the analysis, recommendations are developed for improvement of the activity of the Electric Power Industry Enterprise, using marketing tools; recommendations are given for improving the organizational structure of the enterprise by implementing a specialized full-fledged marketing department in order to solve marketing problems and establish the process of interaction with electricity consumers the economic and social effect of creating a full-fledged marketing department is justified; the company's activities in social networks are analyzed and a number of shortcomings are identified; it is recommended to improve the use of marketing tools in the economic activity of the enterprise to increase competitiveness in the electric power market by using digital marketing tools, namely, improving the design of the business page on Facebook, developing corporate style, changing the ratio of content types, using all platforms for interaction with the target audience in the social network Facebook, changing the presentation of text and visual material in order to increase the effectiveness of perception, creating a page in the promising social network Instagram.
Innovative component as a necessary factor for providing enterprises` development
Authors: Fedyshyn I. , Ikeagwu Favour Kelechi
Published: October 2022

The article examines negative trends and issues of the tourism industry in the world, and in Europe in particular and studies the impact of the crisis caused by the COVID-19 virus on the functioning of tourism and hospitality agencies and firms. Travel and tourism's direct contribution to GDP in the World was approximately 2.9 trillion U.S. dollars in 2019. It was found that United States’ travel and tourism industry contributed the largest sum at 580.7 billion U.S. dollars in 2019. The impact of COVID-19 on tourism in Q1 2020 was 67 million fewer international tourist arrivals, 80 US$ billion lost in exports, 100% destinations with travel restrictions. All parts of the industry have been affected, from hotels, motels and resorts, to bed and breakfasts and home-sharing platforms like Airbnb. It was found that rural tourism is one of the factors that can be a fundament for economic recovery and development not only in EU, but in Ukraine as well. Ukrainian tourism and hospitality faced losses from quarantine and pandemics at $ 3-5 billion. Approximately 80% of hospitality establishments in Ukraine were small businesses, sole proprietors, that didn`t survive the quarantine. The number of nights spent at tourist accommodation establishments in rural areas for 2014-2019 in European Union and some most popular tourist destinations showed a slightly increase from 2014 till 2016 and from 2017 till 2019. In 2019, over 3,5 million domestic tourists and almost 900 thousand international tourists stayed in rural accommodations in Spain. Preventive measures and suggestions for the application of crisis management were submitted in this investigation aimed at increasing innovative flexibility within the enterprise, developing preparatory plans to avoid crisis situations and precautionary measures for their implementation were proposed in the article.
Peculiarities of IKEA management in the world and in Ukraine
Authors: Yuzyk Mariia
Published: October 2022

It is now important for international companies to be able to understand the needs and desires of consumers in the domestic markets in which they operate. In order for a company to be able to compete, it must implement its international strategy on the local spectrum. This article is used to demonstrate how the globally successful company IKEA features of management in the world and its entering the Ukrainian market. First of all, we identified the important elements that caused the development of international trade and main obstacles, which affected global competition of every company in international business where Ikea is not an exception. As there is not clear position of Ikea mission, we tried to define the mission of IKEA has included the following components: different products, available prices, exceeding expectations. Then created an analysis of the design, formation and further successful steps of that company. Focus on the SWOT analysis of the Ikea itself, and also on its analysis in relation to the issue - the Ukrainian market gives us great understanding of strengths(affordability, design, brand reputation, wide range of products), weaknesses(the media, quality, location), opportunities(emerging markets, online store, sustainability) and threats(competition, imitation, quality preference) for better functioning Ikea business strategies in the world and in Ukraine. The competitive advantage is the technology creating stylish products through decades which differents from others and can be recognizable. Ukraine is an important market to expand as Ukrainians are looking for low prices, well-designed and functional household equipment especially with possibility of online store because of influence of current situation with pandemia COVID-19 was also the cause of this phenomenon.
Motivation of self-change fs a condition of personality development
Authors: Perig Iryna , Puharskyi Stanislav
Published: October 2022

The article describes the problem of personality development, the ability to self-improvement, independent choice of changing the trajectory of life. It is substantiated that personal development is a dynamic process of human life and an indicator of life of a mature person, characterized by a person's sense of nature, progressive changes in self-perception, attitude, understanding and mastery of their emotions, actions and deeds, constructive solutions to problems and successful choices. self-presentation of tactics of interaction with other people, etc. Consideration of both positive (need for self-actualization, personal maturity, striving for perfection) and negative factors (inferiority complex, dissatisfaction with quality of life, etc.) of a person's life, can be a reason for self-improvement. Issues of self-change, self-development, personal growth in the context of well-known psychological theories are analyzed: psychoanalytic, humanistic, existential. The factors of determination of changes are divided into objective and subjective, equated to external and internal motivation. It is intrinsic motivation, in our opinion, is the most effective and pivotal in personal development. Carrying out the analysis of scientific sources, the essence and structure of motivation of self-development of the person which is presented as set of motives to self-changes which are directed on increase of level of personal and social competences for realization of own life scenario is defined. The components of motivation for self-improvement include value, emotional, target, activity, cognitive, volitional levels. The main determinants of self-improvement are: the natural need for self-actualization, the level of personal maturity, overcoming the inferiority complex, personal development; dissatisfaction with the quality of life; striving for perfection; feeling like a fully functioning person; desire to correct their own shortcomings, etc.
Integration of management accounting into the information support system of the enterprise
Authors: Bilous Olga , Chaban Natalia , Gabura Zoryana , Semenyuk Olga
Published: October 2022

The problem of development of management accounting at the enterprises of Ukraine is considered. The influence of integration accounting processes on the formation of information support of the enterprise is considered. The main qualities of management accounting are given. Proposals for its implementation at enterprises have been submitted. The main factors on which the success of financial and economic activity depends, namely the available resources (financial, material, labor) and the ability to dispose of them with the greatest efficiency. Finding ways to maximize the profits of enterprises is possible only if the management provides information for decision-making. Basically, such information is formed in the accounting system of the enterprise. However, accounting cannot fully meet the needs of management for the necessary information in a timely manner, as the methods and techniques used in accounting are not suitable for obtaining forward-looking information. That is, accounting is based on generalized information that has the nature of an event that occurred. The Law of Ukraine "On Accounting and Financial Reporting in Ukraine" in Article 8 states that enterprises independently develop a system and forms of internal (management) accounting, reporting and control of business transactions. But at this point the management does not pay due attention and therefore management accounting is insufficiently developed at the enterprises of Ukraine. The shortcomings that hinder the development of the information network of the enterprise, which reduces the effectiveness of new and latest information technologies in the creation of departments of informatization and automation of the accounting service of accounting services. The basic principles by means of which there is a use of network software complexes as a key element of information systems of management accounting are considered.
Human resources development as a part of the enterprise strategy
Authors: Pavlykivska Olha , Halyniak Lesia
Published: October 2022

Theoretical approaches to defining the concept of human resources are analyzed. The own terminological basis of research is formed. It is proved that highly qualified personnel is the key to the success of any enterprise or organization. It is found that the main condition for the successful operation of national enterprises is the development of human resources. The hypothesis that human potential is the main element of enterprise strategy is substantiated. The main task of the personnel strategy of any enterprise is to ensure that the interests of all categories of employees and social groups of the staff are taken into account in everyday personnel work. It is established that investing in human resources is determined by the intensity of replacement of low-skilled labor into highly skilled intellectual, creative and humanized one. In the process of management, the enterprise must constantly improve its staff, which generally increases the efficiency of the enterprise. We are convinced that most professionals strive for continuous growth, development, communication with management at the partnership level. That is why investing in talented people will help companies retain ambitious and promising employees, increase the brand of the employer, reduce labour turnover and improve many other factors. It is found out that the main types of investments in talents are investments in improving the skills and qualifications of specialists, security, entertainment, transportation. Human resource management should contribute to the improvement and development of staff. The costs of staff regulation, retraining and training should be understood as capital investment but not as an expense. It is learned that reducing turnover, increasing productivity, building a system of continuity, improving loyalty and motivation of employees are indicators that are achieved as a result of effective human resource management.