bluuebunny/crossref_metadata_2025 huggingface dataset:
Angiotensin-Inhibiting Drugs Do Not Impact Disease Activity in Patients with Rheumatoid Arthritis: A Retrospective Cross-Sectional Study
Authors: Sluijsmans Dorien M. C. F. , Rohrich Daphne C. , Popa Calin D. , van den Bemt Bart J. F.
Published: May 2021

Objectives: Besides their proven effectivity in decreasing the risk of cardiovascular events, angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II type 1 receptor blockers (ARBs) are likely to possess anti-inflammatory properties as well. This study aims to investigate whether the use of ACEi and ARBs additionally lowers disease activity in patients with rheumatoid arthritis (RA). Methods: In this cross-sectional study, we used ARBs or ACEi to study RA patients who had at least one DAS28-CRP measurement during a one-year period. A control group of RA patients without ACEi/ARBs was randomly selected. The primary outcome was the difference between the DAS28-CRP scores of ACEi/ARBs users and controls. The secondary outcomes were the differences between administered dosages of csDMARDs and bDMARDs for users and controls, respectively; these were expressed in defined daily dose (DDD). Confounders were included in the multiple regression analyses. Results: A total of 584 ACEi/ARBs users and 552 controls were finally examined. Multiple linear regression analyses showed no association between the use of ACEi or ARBs and the DAS28-CRP scores (ACEi factor 1.00, 95% CI 0.94–1.06; ARBs 1.02, 95% CI 0.96–1.09), nor with the dosage of csDMARDs (ACEi 0.97, 95% CI 0.89–1.07; ARBs 0.99, 95% CI 0.90–1.10). Furthermore, the use of ACEi was not associated with reduced dosages of bDMARDs (OR 1.14, 95% CI 0.79–1.64), whereas ARBs users tended to use less bDMARDs (1.46, 95% CI 0.98–2.18, p = 0.06). Conclusion: In this study, the use of either ACEi or ARBs in RA patients had no impact on disease activity as measured by the DAS28-CRP. A trend towards lower bDMARD dosages was observed in ARBs users, but the significance of this finding is still unclear.
Variational Autoencoder for Image-Based Augmentation of Eye-Tracking Data
Authors: Elbattah Mahmoud , Loughnane Colm , Guérin Jean-Luc , Carette Romuald , Cilia Federica , Dequen Gilles
Published: May 2021

Over the past decade, deep learning has achieved unprecedented successes in a diversity of application domains, given large-scale datasets. However, particular domains, such as healthcare, inherently suffer from data paucity and imbalance. Moreover, datasets could be largely inaccessible due to privacy concerns, or lack of data-sharing incentives. Such challenges have attached significance to the application of generative modeling and data augmentation in that domain. In this context, this study explores a machine learning-based approach for generating synthetic eye-tracking data. We explore a novel application of variational autoencoders (VAEs) in this regard. More specifically, a VAE model is trained to generate an image-based representation of the eye-tracking output, so-called scanpaths. Overall, our results validate that the VAE model could generate a plausible output from a limited dataset. Finally, it is empirically demonstrated that such approach could be employed as a mechanism for data augmentation to improve the performance in classification tasks.
Application of the Machine Learning LightGBM Model to the Prediction of the Water Levels of the Lower Columbia River
Authors: Gan Min , Pan Shunqi , Chen Yongping , Cheng Chen , Pan Haidong , Zhu Xian
Published: May 2021

Due to the strong nonlinear interaction with river discharge, tides in estuaries are characterised as nonstationary and their mechanisms are yet to be fully understood. It remains highly challenging to accurately predict estuarine water levels. Machine learning methods, which offer a unique ability to simulate the unknown relationships between variables, have been increasingly used in a large number of research areas. This study applies the LightGBM model to predicting the water levels along the lower reach of the Columbia River. The model inputs consist of the discharges from two upstream rivers (Columbia and Willamette Rivers) and the tide characteristics, including the tide range at the estuary mouth (Astoria) and tide constituents. The model is optimized with the selected parameters. The results show that the LightGBM model can achieve high prediction accuracy, with the root-mean-square-error values of water level being reduced to 0.14 m and the correlation coefficient and skill score being in the ranges of 0.975–0.987 and 0.941–0.972, respectively, which are statistically better than those obtained from physics-based models such as the nonstationary tidal harmonic analysis model (NS_TIDE). The importance of subtide constituents in interacting with the river discharge in the estuary is clearly revealed from the model results.
Interaction between Omeprazole and Gliclazide in Relation to CYP2C19 Phenotype
Authors: Dujic Tanja , Cvijic Sandra , Elezovic Amar , Bego Tamer , Imamovic Kadric Selma , Malenica Maja , Elezovic Alisa , Pearson Ewan R. , Kulo Aida
Published: May 2021

The antidiabetic drug gliclazide is partly metabolized by CYP2C19, the main enzyme involved in omeprazole metabolism. The aim of the study was to explore the interaction between omeprazole and gliclazide in relation to CYP2C19 phenotype using physiologically based pharmacokinetic (PBPK) modeling approach. Developed PBPK models were verified using in vivo pharmacokinetic profiles obtained from a clinical trial on omeprazole-gliclazide interaction in healthy volunteers, CYP2C19 normal/rapid/ultrarapid metabolizers (NM/RM/UM). In addition, the association of omeprazole cotreatment with gliclazide-induced hypoglycemia was explored in 267 patients with type 2 diabetes (T2D) from the GoDARTS cohort, Scotland. The PBPK simulations predicted 1.4–1.6-fold higher gliclazide area under the curve (AUC) after 5-day treatment with 20 mg omeprazole in all CYP2C19 phenotype groups except in poor metabolizers. The predicted gliclazide AUC increased 2.1 and 2.5-fold in intermediate metabolizers, and 2.6- and 3.8-fold in NM/RM/UM group, after simulated 20-day dosing with 40 mg omeprazole once and twice daily, respectively. The predicted results were corroborated by findings in patients with T2D which demonstrated 3.3-fold higher odds of severe gliclazide-induced hypoglycemia in NM/RM/UM patients concomitantly treated with omeprazole. Our results indicate that omeprazole may increase exposure to gliclazide and thus increase the risk of gliclazide-associated hypoglycemia in the majority of patients.
Association between HOTAIR lncRNA Polymorphisms and Coronary Artery Disease Susceptibility
Authors: Kim In-Jai , Lee Jeong-Yong , Park Hyeon-Woo , Park Han-Sung , Ko Eun-Ju , Sung Jung-Hoon , Kim Nam-Keun
Published: May 2021

Coronary artery disease (CAD), one of the most frequent causes of mortality, is the most common type of cardiovascular disease. This condition is characterized by the accumulation of plaques in the coronary artery, leading to blockage of blood flow to the heart. The main symptom of CAD is chest pain caused by blockage of the coronary artery and shortness of breath. HOX transcript antisense RNA gene (HOTAIR) is a long non-coding RNA which is well-known as an oncogene involved in various cancers, such as lung, breast, colorectal, and gastric cancer. We selected six single nucleotide polymorphisms, rs4759314 A>G, rs1899663 G>T, rs920778 T>C, rs7958904 G>C, rs12826786 C>T, and rs874945 C>T, for genotype frequency analysis and assessed the frequency of HOTAIR gene polymorphisms in 442 CAD patients and 418 randomly selected control subjects. To analyze the differences between these two populations, we performed a Student’s t-test, adjusted odds ratio (AOR), 95% confidence intervals (CIs), and ANOVA analysis. According to our baseline characteristic analysis, control subjects and CAD patients were significantly different in hypertension and diabetes mellitus. We also found that the rs4759314 A>G, rs1899663 G>T, and rs12826786 C>T genotypes were strongly associated with CAD susceptibility (AA vs. AG+GG: AOR = 0.608, 95% CI = 0.393−0.940, p = 0.025; GG vs. TT: AOR = 2.276, 95% CI = 1.125−4.607, p = 0.022; CC vs. CT+TT: AOR = 1.366, 95% CI = 1.027−1.818, p = 0.032, respectively). Our data also demonstrated that the genotype of HOTAIR polymorphisms, genotype combination, and haplotype analysis affect disease occurrence. Moreover, these polymorphisms are linked to clinical factors that contribute to disease susceptibility. In conclusion, results from our study suggest that HOTAIR polymorphisms may be useful novel biomarkers for diagnosing CAD.
Design and Analysis of Cancer Clinical Trials for Personalized Medicine
Authors: Jung Sin-Ho
Published: May 2021

Biomarkers play a key role in the development of personalized medicine. Cancer clinical trials with biomarker should be appropriately designed and analyzed reflecting the various factors, such as the phase of trials, the type of biomarker, the study objectives, and whether the used biomarker is already validated or not. In this paper, we demonstrate design and analysis of two phase II cancer clinical trials, one with a predictive biomarker and the other with a prognostic biomarker. A statistical testing method and its sample size calculation method are presented for each of the trials. We assume that the primary endpoint of these trials is a time to event variable, but this concept can be used for any type of endpoint with associated testing methods. The test statistics and their sample size formulas are derived using the large sample approximation based on the martingale central limit theorem. Using simulations, we find that the test statistics control the type I error rate accurately and the sample sizes calculated using the formulas maintain the statistical power specified at the design stage.
Month-End Regularities in the Overnight Bank Funding Markets
Authors: Baig Ahmed S. , Winters Drew B.
Published: May 2021

The money market rates in the United States exhibit various calendar patterns that are grounded in institutional and regulatory factors. In this paper, we document a new regularity in the overnight fed funds market. Specifically, we identify patterns of decreased volatility along with consistent and significant month-end rate drops in the fed fund rates. Our findings suggest that short-term liquidity requirements of the Basel III reforms are, in part, responsible for the regularity in fed funds.
Gamesmanship and Seasonality in U.S. Stock Returns
Authors: Ackert Lucy F. , Athanassakos George
Published: May 2021

We re-examined the seasonal pattern in the excess returns of highly visible American firms. In contrast to the seasonality for risky, less visible firms, we found that highly visible stocks display return seasonality that shows the opposite trend. Fund managers are prone to gamesmanship, putting downward pressure on prices for highly visible firms at the beginning of the year, which is reversed later with buying pressure. Due to the bonus culture, fund managers start the year by buying small, risky stocks in order to beat benchmarks. Once targets are met, they adjust toward visible, less risky stocks to lock in returns, providing them with a seasonal returns pattern opposite to that of small firms. A re-examination is warranted because the world has become increasingly globalized, and some argue that managers’ incentives are aligned with investors due to increased scrutiny. We used analyst following as a proxy for visibility and examined the seasonal pattern for 1997–2018. Though the anomaly was first reported twenty years ago, it persists in recent data. Rational investors may be limited in their ability to arbitrage mispricing because institutional investors who drive the market are self-interested. Future research may examine the seasonal pattern in countries with more stringent regulation of financial professionals or with high-frequency data.
Effects of the 2008 Financial Crisis and COVID-19 Pandemic on the Dynamic Relationship between the Chinese and International Fossil Fuel Markets
Authors: Tang Chaofeng , Aruga Kentaka
Published: May 2021

This study examines whether the dynamic relationship between the Chinese and international fossil markets changed during the 2008 financial crisis and is changing during the COVID-19 pandemic. The impact of the crises are analyzed by including the periods affected by the crises as dummy variables in the VAR and VECM models. Monthly data for the 2000:1–2020:12 period were used in the study. Our results suggest that the effects of the COVID-19 on the linkages between the Chinese and international fossil fuel markets are not as evident compared to the 2008 financial crisis. The study identifies that the effects of the 2008 financial crisis and the COVID-19 pandemic on the linkages are mostly driven by the impacts of these crises on the Chinese fossil fuel markets. The study indicates the importance of controlling the risk involved in the Chinese fossil fuel market when events like the 2008 financial crisis and the COVID-19 pandemic are changing the linkages between the Chinese and international fossil fuel markets.
The mechanism of development of the system of motivation of labor activity of employees of agricultural organizations
Authors: Sheveleva I. , Shevelev V.
Published: May 2021

The main stages and characteristics of the work aimed at the development and formation of a system of motivation of employees of agricultural organizations are given.
Rationing of material costs in the technical service of animal husbandry
Authors: Kovalev L. , Kovalev I.
Published: May 2021

The diversification of the development of animal husbandry in Belarus, and especially its dairy sector, imposes additional requirements for the efficient and rational use of material resources. In the republic and abroad, many scientific articles are published on the issues of resource conservation, rationing and saving of raw materials, materials, fuel and energy. However, the necessary modern scientifically based standards for the needs of the livestock industry in spare parts and materials are currently extremely insufficient. The existing standards either have not found proper practical application in modern production conditions, or are completely outdated and can no longer be applied in the current conditions of rapidly developing market relations. The development of progressive standards for the maintenance and repair of livestock equipment from the point of view of scientific cost rationing practices is a necessary and relevant topic. The current level of development of industrial technologies dictates high requirements for the reliability of machines and equipment as a result of their efficient and economical operation. It is based on the mandatory use of the latest means of control and adjustment of technological equipment and requires a comprehensive approach to solving engineering and technical problems. This problem is particularly relevant for the livestock industry, as here the operating costs of equipment are up to 18 %, and in the dairy sector of livestock, the operating costs of machinery and equipment along the entire chain: from the livestock farm to the processing plant and to the sales counter, can exceed 20% in the cost of final products. In this study, the material costs of technical services in animal husbandry are determined by several normative-forming factors, using the methods of multivariate regression analysis, dependencies are established based on the categories of complexity for maintenance and repair by groups of machines and equipment used in animal husbandry. A clear justification is given for the use of the developed standards in the maintenance of livestock equipment in order to save material resources on livestock farms and in complexes in today's conditions.
Love God Totally, and Your Neighbor as Yourself: How Religious Freedom Enables Us to Obey both Great Commandments in Our Time
Authors: Carlson-Thies Stanley
Published: May 2021

no abstract as it is a transcript of a lecture
ANTIMICROBIAL SUSCEPTIBILITY PROFILES AND FREQUENCY OF THE SCPB AND LMB VIRULENCE GENES AMONG STREPTOCOCCUS AGALACTIAE FROM PREGNANT WOMEN EXAMINED IN HUE MEDICAL UNIVERSITY HOSPITAL
Authors: Nguyen Thi Chau Anh , Nguyen Thi Phuc Loc , Nguyen Chien Thang , Le Van An
Published: May 2021

Objectives: Data on the antimicrobial susceptibility profiles and the frequency of the scpB and lmb virulence genes among Streptococcus agalactiae (GBS) from pregnant women could develop a strategic for preventing neonatal GBS infections.

This study was aimed (1) To determine the antibiotic susceptibility of GBS strains isolated from the pregnant women; and (2) To determine the scpB and lmb virulence genes among isolated GBS strains.

Materials and method: 24 GBS strains were subjected to the antibiotic susceptibility testing (AST) by the disc diffusion (Kirby-Bauer) method. The virulence genes (scpB and lmb) were detected by using PCR method.

Results: All 24 GBS were susceptible to penicillin, cefotaxime, vancomycin and clindamycin. A large proportion of GBS isolates were found to be resistant to erythromycin (75%) and tetracycline (66.7%). The resistance rates for levofloxacin and chloramphenicol were 54.2% and 20.8%, respectively. The scpB gene was present in 95.8% of these GBS isolates and the lmb in 91.7% of isolates.

Conclusion: Penicillin is still the antibiotic of the first choice for GBS infection treatment in Hue Medicаl University Hospitаl; clindamycin or vancomycin could be used for penicillin-allergic patients. Erythromycin should be prescribed with caution. Most of the strains were positive for scpB and lmb genes.

Key words: Streptococcus agalactiae (GBS), virulence gene, antimicrobial susceptibility profiles, pregnant woman
SUGGESTION FOR DIFFERENTIAL DIAGNOSIS OF SOME DISEASES IN SEPERATING/SCREENING PROCESS FOR SUSPECTED PATIENTS WITH COVID-19 AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Tran Dinh Binh , Tran Thanh Loan
Published: May 2021

Separating/screening patients to avoid SAR-CoV-2 infections from suspected patients with COVID-19 entering the clinics and hospitals is extremely important. However, many other disease groups also have clinical signs and epidemiological factors that are quite similar to COVID-19. Therefore, carefully screening examination and differentiation are necessary to avoid an increasing number of suspected cases, by which isolation monitoring and identified diagnostic must be performed, not to mention that it will slow down their main disease diagnostic and treatment. These suggestions hopefully contribute to improving the separating/screening process in clinics and emergency rooms when COVID-19 is spreading and causing disease around the world

Key words: separating, screening, COVID-19, SARS-CoV-2, chest CT scanner
СУЧАСНИЙ СТАН ТА ПРОБЛЕМИ “ЦИФРОВІЗАЦІЇ” В УКРАЇНІ
Authors: Dovbysh A.S.  , Kotukh Ye.V.
Published: May 2021

У статті досліджено особливості цифровізації в публічному управлінні, сформульовано основні  напрями забезпечення кібербезпеки при цьому. З урахуванням комплексного науково-методологічного аналізу висвітлені окремі особливості організації комунікації суб’єктів публічного управління залежно від рівня та розміру організації. Проаналізовано сучасний стан кібербезпеки, а також визначено шляхи підвищення її рівня в сфері публічно го управління та в цілому в Україні. Пріоритетним шляхами підвищення рівня кібербезпеки в публічному секторі в сучасних умовах має стати збільшення бюджетного фінансування відповідної сфери, стратегічне інвестування в кібераналітику і хмарні технології, створення в організаціях спеціальних підрозділів з кіберзахисту, установка сучасного програмного забезпечення та його постійне оновлення, регулярне підвищення кваліфікації всіх працівників з питань захисту організаційної та персональної інформації.
ДОСЛІДЖЕННЯ МЕТОДИК ТАЙМ-МЕНЕДЖМЕНТУ ТА ЇХ ВИКОРИСТАННЯ В ДІЯЛЬНОСТІ ДЕРЖАВНИХ СЛУЖБОВЦІВ
Authors: Lashenko O.V.  , Serohin S.S.  , Serogina N.K.
Published: May 2021

Розглянуто сутність тайм-менеджменту та необхідність його використання для під-вищення результативності використання робочого часу у діяльності державних службов-ців. Розкрито особливості планування робочого часу. Розглянуто існуючі методики тайм-менеджменту з метою їх використання під час формування власної системи управління ро-бочим часом державних службовців. Наведено переваги використання там-менеджменту вдіяльності держаних службовців.
СОЦІАЛЬНІ ІННОВАЦІЇ ЯК СКЛАДОВА ДЕРЖАВНОЇ СОЦІАЛЬНОЇ ПОЛІТИКИ
Authors: Volska O.М.
Published: May 2021

Розглянуто теоретичні засади соціальних інновацій. Наведено погляди українських ізакордонних науковців на природу соціальних інновацій. Доведено, що соціальні інноваціїможуть мати чотири визначення: нове вирішення соціальної проблеми; інноваційний про-дукт, застосування якого може вплинути на вирішення соціальної проблеми; шлях розпо-всюдження соціальної інновації; унікальність соціальної інновації. Наведено приклади со-ціальних інновацій в освітню сферу. Визначено роль соціальних інновацій у державній со-ціальній політиці.
Основні принципи реалізації культурної політики в Європі та завдання для України
Authors: Kolisnichenko N. M.
Published: May 2021

У статті досліджуються поняття «культурна політика», «управління культурною політикою» в європейському контексті. Розглядаються практики державної політики у галузі культури, досліджуються режими культурної політики в Європі, які побудовані на основі трьох спільних політичних пріоритетів: збереження мистецької та історичної спадщини; підтримка мистецтва і творчості, яка відрізняється від попередньої моделі державного патронажу; взаємозв’язок між демократією та культурою (як рівний доступ до культури). Виділяються напрямки та інструменти державного управління в галузі європейської культури. Визначаються позитивні для наслідування культурні практики. Розглядаються пріоритети ЄС в сфері культурної політики і з огляду на це обґрунтовуються можливості та відповідні завдання для України.
Фінансування розвитку освітньої сфери України як механізм її державного регулювання
Authors: Zastrozhnikova I. V.
Published: May 2021

У статті розглянуто основні види освіти, закріплені у Законі України «Про освіту», та основні проблемні аспекти фінансування освітньої галузі країни в сучасних умовах. Проаналізовано фінансування освітньої сфери за роками за 10 років, яке є нерівномірним. Наголошено на необхідності збільшення заробітної плати вчителям та знеціненні їх праці в порівнянні з іншими країнами Європи. Вказано на недостатню спроможність української системи освіти надавати якісні сучасні освітні послуги та, у зв’язку з цим, на необхідність залучення іноземних інвестицій та грантових коштів для розбудови української освіти.
Сучасні інструменти взаємодії в системі публічного управління
Authors: Mykhailovska O. V.
Published: May 2021

У статті досліджено сучасні інструменти взаємодії в системі «влада – громадськість» як основу демократичного розвитку. Охарактеризовано наявний стан щодо звернень громадян до органів влади, тематики питань, які порушувались, популярних комунікаційних каналів. Досліджено динаміку проведених Урядом України консультацій з громадськістю та їх види, а також кількість поданих електронних петицій. Визначено основні позитивні зрушення в системі взаємодії та негативні стороні, що потребують докладання зусиль.
ПЕРСПЕКТИВИ РОЗВИТКУ ПРОФСПІЛОК В УМОВАХ ТРАНСФОРМАЦІЇ СИСТЕМИ РЕГУЛЮВАННЯ СОЦІАЛЬНО-ТРУДОВИХ ВІДНОСИН
Authors: Zhadan  O. 
Published: May 2021

Статтю присвячено питанню визначення перспективних напрямів розвитку профспілок в умовах трансформації системи регулювання соціально-трудових відносин. Проаналізовано кількісні та якісні характеристики функціонування профспілкового руху в Україні та світі. Виявлено сучасні тенденції трансформаційних процесів у сфері соціально-трудових відносин, серед яких: поширення нестандартних форм зайнятості; зростання адаптивності й різноманіття соціально-трудових відносин; підвищення рівня автономності і незалежності працівників; згортання сфери стабільної зайнятості; великі масштаби поширення запозиченої праці та тимчасової зайнятості серед молоді; стрімке збільшення обсягів неофіційної зайнятості. Виокремлено найбільш імовірні сценарії розвитку профспілок на майбутнє.
КОНЦЕПТУАЛЬНІ ОСНОВИ ГЛОБАЛЬНОГО УПРАВЛІННЯ У СФЕРІ БЕЗПЕКИ ТА ОБОРОНИ: ЄВРОПЕЙСЬКИЙ КОНТЕКСТ І УКРАЇНА
Authors: Kalyayev  A. 
Published: May 2021

Узагальнено концептуальні основи глобального управління у сфері безпеки в європейському контексті. Наведено концептуальні підходи в дослідженні проблем глобального управління у сфері безпеки на міждисциплінарній основі. Аргументовано, що глобальне управління у сфері безпеки є комплексним явищем, структура якого враховує галузеву специфіку. Національну безпеку в умовах зміни загального характеру війн і збройних конфліктів розглянуто як відкриту, динамічну, соціальну систему, що є органічним складником систем міжнародної безпеки та глобального управління в цій сфері. Наголошено на тому, що виникнення нових суперечностей, збройних конфліктів і нових силових центрів міжнародної політичної системи стало багатополярним. Зроблено акцент на недоцільності перебільшення ролі міжурядових організацій та інститутів у вирішенні питань міжнародної безпеки, адже реалізація будь-яких глобальних рішень неможлива без участі і без урахування інтересів національних держав. Розкрито особливості “гібридних війн” і “гібридних загроз” та їхній потужний руйнівний потенціал. Послідовно проводиться думка, що організація протидії такій системі загроз вимагає вчасної ідентифікації їх на теоретичному рівні та визначення статусу і заходів із протидії – на практичному рівні, за обов’язкової координації зусиль з міжнародними структурами безпеки та підтримки з боку впливових держав. Аргументовано, що нині баланс сил та інтересів у світі порушено, змінено характер, масштаби та зміст глобальних викликів, загроз та ризиків, які формуються на регіональному й локальному рівнях, набуваючи дедалі більш комплексного характеру. Відзначено, що геополітичне суперництво та боротьба великих держав за ресурси мають загрозливу проєкцію на регіональному й локальному рівні.
ASSESSMENT OF AGE-STRATIFIED LOCKDOWN IMPOSED DURING THE COVID-19 PANDEMIC REGARDING PROHIBITION OF DISCRIMINATION
Authors: BOZKURT Fatma Duygu
Published: May 2021

Age-stratified lockdown is one of the measures implemented in Turkey to control the new coronavirus outbreak. This article examines the constitutionality of the age-stratified lockdown and argues that by restricting the freedom of movement and the right to work, this measure violates the prohibition of discrimination principle. This study determines whether the age-stratified lockdown is based on discrimination, which is prohibited by the Turkish Constitution. In the descriptive analysis, it considers whether there is a justifiable reason for differential treatment as a result of this measure. In the light of the resulting data, the article concludes with an assessment of the age-stratified lockdown’s compliance with the prohibition of discrimination.
REŞİT OLMAYANLA CİNSEL İLİŞKİ SUÇUNDA FAİL (TCK m.104)
Authors: SARIGÜL Ali  Tanju
Published: May 2021

Türk Ceza Kanunu’nda cinsel dokunulmazlığa karşı suçlarda öğretide üzerinde en çok tartışılan suç “reşit olmayanla cinsel ilişki” suçu olmuştur. Özellikle rızaya dayalı cinsel ilişkinin her iki tarafının da reşit olmaması ya da on sekiz yaşın altında olması durumunda ceza hukukunun müdahale alanı dışında kalması gerektiği konusunda öğretide görüş birliği bulunmaktadır. Ancak hukuk uygulamamızda on beş yaşın üzerindeki akran çocuklar arasında gerçekleşen rızaya dayalı cinsel ilişkilerin suç olarak kabul edildiği, herhangi başka bir değerlendirme bile yapılmasına ihtiyaç duyulmaksızın erkek çocuğun fail, kız çocuğun ise mağdur olarak belirlendiği görülmektedir. Korunan hukuki yararla uyuşmadığını değerlendirdiğimiz ve bir gerekçeye dayanmayan bu kararlar, uygulamada tutarsız sonuçlara ve mağduriyetlere neden olmaktadır.

Kanaatimizce sorunun çözümü; kanun hükmünün Avrupa Konseyi Çocukların Cinsel Sömürü ve İstismara Karşı Korunması Sözleşmesi kapsamında yapılabilecek bir yorumuyla mümkün olabilecektir. Söz konusu Sözleşmede bir çocukla cinsel faaliyette bulunmanın yasak olduğu yaş alt sınırının taraf devletlerce belirlenmesi gerektiği hüküm altına alınmıştır (m.18). Sözleşme kapsamında dikkat edilmesi gereken diğer husus ise çocuklar arasındaki rızaya dayalı cinsel faaliyetlerin bu kapsamda değerlendirilmemesi gerektiğidir. Dolayısıyla çocuklar arasındaki rızaya dayalı cinsel ilişki, ceza hukukunun dışında tutulmalı, suçun faili olabilmek için on sekiz yaşın tamamlanmış olması koşulu aranmalıdır.
CAN THE POLICE USE WEAPONS IN CASES OTHER THAN LEGITIMATE DEFENCE? A COMPARATIVE STUDY WITH THE FRENCH EXAMPLE
Authors: ÇETİNKAYA M. Buhari
Published: May 2021

Law enforcement forces are authorized to the use of weapons in accordance with their duties. The use of the body-targeted weapons conflicts with the right to life and body integrity. The limits of this authority, which conflicts with the most valuable rights, should be determined very well. Law enforcement forces should exercise this authority within the framework of criteria and instructions that leave no room for doubt. Events that took place in Turkey, in 2014, the terrorist attacks that took place in France, in 2015 and 2016 have led to the re-opening of discussion on these authorities.

Law enforcement forces is equipped with the authority to the use of weapons within the framework of their duty to maintain public order. This authority is related to the authorization of the law. Additionally, in connection with its public duty, they are obliged to prevent attacks that will take place within the context of preventive activities it carries out. This is also related to the legitimate defence. The authorization of the law implies a broader concept than legitimate defence. The French legislator, considering that the powers of the national police are insufficient in the face of the attacks that took place in recent years, evaluated the authority to the use of weapons in a different framework. Evaluating the perspective of the actuality condition of the legitimate defence broader, can lead to a broader concept than the legitimate defence. It can be also concluded that the concept of legitimate defence has not been abandoned due to the fact that the necessity and proportionality conditions of legitimate defence has become much stricter.

In this study, we will examine how the new French framework law related to the use of weapons establishes a legitimate defence concept specific to the law enforcement forces. In this direction, we will consider the situation in Turkish law.
PENGARUH KEMUDAHAN PENGGUNAAN, KEPERCAYAAN DAN KEPUASAN TERHADAP NIAT BELI ULANG KONSUMEN DI SHOPEE
Authors: Retno Ningrum Diah Ayu , Anto Sus , Maharani Bernadetta Diansepti
Published: May 2021

Perkembangan teknologi di era globalisasi sekarang ini membuat internet semakin berkembang ke lapisan masyarakat sehingga media internet sangat berguna dalam aplikasi bisnis yang disebut e-commerce. Salah satu e-commerce yang ikut meramaikan dunia bisnis yaitu Shopee. Shopee merupakan aplikasi jual beli online dengan menawarkan jual beli yang menyenangkan, gratis dan juga terpercaya. Keberlangsungan Shopee untuk memenangkan persaingan pasar dalam bisnis online juga dipengaruhi oleh niat beli ulang konsumen. Faktor yang menentukan tinggi rendahnya niat beli ulang antara lain yaitu kemudahan penggunaan, kepercayaan, dan kepuasan. Penelitian yang dilakukan untuk mengetahui tentang adanya pengaruh kemudahan penggunaan, kepercayaan dan kepuasan terhadap niat beli ulang konsumen di Shopee. Variabel bebas yang digunakan yaitu kemudahan penggunaan, kepercayaan, dan kepuasan sedangkan variabel terikat yaitu niat beli ulang. Dalam penelitian ini yang menjadi populasi adalah mahasiswa aktif fakultas ekonomi Universitas Sarjanawiyata Tamansiswa Yogyakarta tahun angkatan 2019 dan tahun angkatan 2020 yang berjumlah 1.123 mahasiswa kemudian diambil sampelnya sebanyak 120 responden. Dalam penelitian ini metode pengambilan sampel yaitu purposive sampling dengan pengumpulan data menggunakan kuesioner. Kuesioner kemudian dibuat menggunakan google form dan disebarkan melalui media sosial whatsapp dan telegram. Data yang sudah didapatkan kemudian dianalisis secara kuantitatif menggunakan Software SPSS ver. 23.0. Hasil dari penelitian yang dilakukan menunjukkan bahwa kemudahan penggunaan, kepercayaan, dan kepuasan secara (simultan) bersama-sama berpengaruh signifikan terhadap niat beli ulang konsumen di Shopee, kemudahan penggunaan berpengaruh signifikan terhadap niat beli ulang konsumen di Shopee, kepercayaan berpengaruh signifikan terhadap niat beli ulang konsumen di Shopee, kepuasan tidak berpengaruh terhadap niat beli ulang konsumen di Shopee.
ISAS (Attention, Interest, Search, Action, Share) Model of Cosmetics Marketing Communication on Online Beauty Forum (Case-Study: Avoskin Marketing on Sociolla)
Authors: Humaira Nadia
Published: May 2021

Di era digital, konsep AISAS (Attention, Interest, Search, Action, Share) relevan untuk menggambarkan perilaku audience dalam mengambil keputusan pembelian. AISAS menekankan pada dua perilaku konsumen yang unik, yaitu mengumpulkan dan berbagi informasi yang menjadi faktor penting dalam keputusan pembelian. Paradigma penelitian ini menggunakan paradigma postpositivis dengan pendekatan kualitatif, metode studi kasus dan jenis penelitian deskriptif menggunakan data yang ada atau tersedia berupa jejak digital yang diambil melalui wawancara mendalam kepada informan yang berpengalaman berbelanja melalui Sociolla selain itu data diambil pada media online seperti situs resmi Sociolla (sociolla.com), forum online Soco by Sociolla (Soco.id), dan saluran media sosial Instagram Sociolla, khususnya konten pemasaran kosmetik Avoskin tahun 2020. Hasil penelitian ini menunjukkan bahwa pemasaran kosmetik (Avoskin) melalui forum online (Sociolla) memungkinkan khalayak dan konsumen untuk mengumpulkan dan berbagi informasi sebagai dirangkum dalam konsep AISAS. Fitur pendukung yang ada di Sociolla, seperti diskusi forum online, posting review, dan e-commerce, memasarkan kosmetik secara lebih informatif dan menggunakan pihak ketiga sebagai jembatan antara kosmetik dan audiens digital.
The Dynamics Transformation Of Living Media Consumption In The Digital Era (Shifting Preferences Study From Mediated Media Editors To Unmediated Media Editors And To Mediated Media Editors)
Authors: Firman Kurniawan Yeremia Angga Sugiyanto,
Published: May 2021

Pada perkembangan teknologi saat ini memiliki perubahan yang sangat signifikan khususnya dalam dunia media massa. Digitalisasi yang terus berkembang pesat ini mempengaruhi komunikasi masa yang memiliki cakupan luas sehingga dapat menghubungkan kepada khalayak secara cepat. Salah satu pergeseran paradigma yang terjadi yaitu dari editor-mediated ke non-editor mediated. Hal ini menjadikan pergeseran ini sebagai salah satu dampak dari perkembangan teknologi yang penting untuk dikaji. Dengan perkembangan tersebut khalayak memiliki peran besar dalam memperoleh informasi dan membuat berbagai pilihan informasi yang ingin didapatkan. Penelitian ini bertujuan untuk mengetahui dinamika transformasi konsumsi media dari editor-mediated ke non-editor mediated. Dalam penelitian ini menggunakan teori User and Gratification untuk melihat peran aktif dalam proses komunikasi dalam memenuhi kebutuhannya. Adapun pendekatan dan metode penelitian ini menggunakan pendekatan kualitaif dengan metode fenomenologi untuk melihat saling berpengaruhnya satu peristiwa dengan situasi tertentu. Hasil dalam penelitian ini pada era digital ini konsumen atau pembaca berita beralih menjadi pengguna yang lebih aktif dalam melakukan diskusi dan mengemukakan aspirasinya. Hal ini menghasilkan paradigm baru media dengan dari editor-mediated menjadi non-editor mediated sehingga dalam penelitian yang dilakukan ini perkembangan teknologi turut mempengaruhi dan dapat membantu khalayak dalam memperoleh informasi. Dalam preferensi ini faktor trust merupakan kunci dari kredebilitas suatu media untuk menjaga kualitas konten dan layanan yang diberikan sehingga khalayak akan menumbuhkan harapan yang baik untuk dimasa yang akan datang.
Perilaku Komunikasi Suku Pedalaman Polahi dalam Berinteraksi dengan Masyarakat Luar Suku
Authors: Dano Citra Putri
Published: May 2021

Suku Polahi merupakan suku asli Gorontalo yang hingga saat ini masih ada dan hidup di wilayah-wilayah pedalaman Gorontalo. Salah satunya di Desa Tamaila, Kabupaten Gorontalo. Sebagai suku pedalaman, dahulu Polahi dikenal enggan untuk berinteraksi dengan masyarakat di luar suku, walaupun secara geografis tempat tinggal mereka dekat dengan perkampungan warga. Namun saat ini, khususnya di Desa Tamaila suku Polahi mulai membuka diri dan mau untuk berinteraksi dengan masyarakat desa sekitar, walaupun masih terbatas pada tujuan untuk pemenuhan kebutuhan hidup mereka. Penelitian ini bertujuan untuk melihat perilaku komunikasi suku Polahi saat berinteraksi dengan masyarakat dari luar suku mereka. Penelitian ini menggunakan metode pengumpulan data dengan cara observasi non partisipan, yang artinya peneliti hanya melihat fenomena interaksi suku polahi dan masyarakat luar suku secara umum, tanpa melibatkan diri dalam kehidupan keseharian. Hasil penelitian mengungkapkan bahwa sebagian anggota suku Polahi sudah mulai membuka diri untuk hidup berdampingan dengan masyarakat luar suku. Terbukti dari aktivitas untuk memenuhi kebutuhan hidup (mata pencaharian, dan proses jual beli di pasar). Kendala – kendala dalam berinteraksi yang ditemukan selama proses komunikasi (misalnya, kendala Bahasa dan perilaku non verbal yang mengundang perbedaan pemahaman) bisa diatasi dengan cara memanfaatkan anggota suku Polahi yang dinilai lebih berpendidikan (beberapa anak dari suku Polahi sudah bersekolah) untuk menjadi penerjemah. Peneliti menyimpulkan bahwa perilaku komunikasi suku Polahi sudah mengalami pergeseran, disebabkan adanya motivasi untuk menjalin hubungan dengan masyarakat luar.
Persepsi Pemilih Pemula Terhadap Kampanye Politik Perempuan Melalui Instagram (Studi Deskriptif : Persepsi Mahasiswa Prodi Ilmu Komunikasi UNJ Terhadap Kampanye Politik Krisdayanti Melalui Instagram)
Authors: Rosdiani Khairunnisa , Putri K. Y.S.
Published: May 2021

Instagram digunakan oleh para calon legislatif untuk menjadi sarana berkampanye guna menumbuhkan citra positif serta menarik suara dari para pengguna instagram. Kecerdasan memilih untuk para pemilih pemula juga dilihat dari kepopuleran calon legislatif, serta luasnya jangkauan media sosial dapat membuat semakin tinggi dukungan untuk para calon legislatif. Metode penelitian menggunakan kuantitatif deskriptif dengan teknik yang digunakan yaitu dalam pengumpulan data dalan bentuk kuesioner. Pemilih pemula di prodi Ilmu Komunikasi UNJ menjadi sample dengan jumlah 55 orang dari total 120 mahasiswa ilmu komunikasi UNJ.  Hasil penelitian menunjukkan bahwa pemilih pemula di prodi ilmu komunikasi unj dalam persepsi pemilih pemula dengan aspek memilih, mengatur serta menginterprestasikan ternyata masih kurang dalam studi kasus kampanye krisdayanti di instagram maupun calon legislative lainnya.
Commodification Of Papua Social Conflicts In Social Media In National Security Perspective
Authors: Ramadhan Yusuf syibly , Puspitasari Maria
Published: May 2021

Hoaxes are information manipulated for a specific purpose, in Papua in 2019 the spread of hoax information on the issue of racism was widespread on social media and triggered riots in various parts of Papua. This study uses a qualitative descriptive method, the data is processed through extracting, tracing books, newspapers, newspapers, magazines, journals, and social media observations and other notes that can support research to see how the phenomenon of the commodification of the Papuan conflict is then presented in the form of hoax information. as well as make descriptions, descriptions or paintings in a systematic, factual and accurate manner regarding the facts, characteristics and relationships between the phenomena being investigated. The results found that the commodification of the Papuan conflict, especially the issue of racism, was then packaged in the form of hoax information using hostility narratives or NKRI VS Papua which then caused a threat to national security
Exame Clínico Objetivo Estruturado na avaliação formativa
Authors: Chaves Junior Nilson , Souza Maria Cristina Almeida de , Côrtes Junior João Carlos de Souza , Côrtes Paula Pitta de Resende , Martins Milton de Arruda
Published: May 2021

A formação em medicina demanda o desenvolvimento de competências pelos estudantes, exigindo-lhes mobilização de conhecimentos, habilidades e atitudes para lidarem com situações da prática profissional. O Exame Clínico Objetivo Estruturado (OSCE) constitui-se em estratégia para avaliar competências em ambientes simulados. Este estudo, uma pesquisa quantitativa, descritiva e transversal, teve por objetivo avaliar a percepção dos estudantes do sétimo e do oitavo períodos de um curso de Medicina sobre alguns fatores que interferiram no seu desempenho durante o OSCE. A amostra, não probabilística por conveniência, foi constituída por 101 estudantes, representando 64,7% do universo. A coleta de dados foi realizada virtualmente através de um formulário Google Forms, enviado aos estudantes por meio de seus endereços eletrônicos. Concluiu-se que a percepção dos estudantes foi positiva em relação ao exame, ainda que ajustes se revelem necessários, sinalizando para a viabilidade e factibilidade de novas edições do OSCE no curso de Medicina.
INTERNALISASI NILAI-NILAI TASAWUF DI PONDOK PESANTREN AL-AMIEN PRENDUAN
Authors: Sutrisno Andri
Published: May 2021

Ilmu tasawuf merupakan suatu ilmu yang mengutamakan diri manusia agar memiliki  kebersihan ruhani dan jiwa. Di Pondok Pesantren al-Amien Prenduan menanamkan nilai-nilai yang ada dalam ilmu tasawuf. Hal ini bertujuan agar para santri selalu taat pada perintah Allah Swt. dan memiliki nilai-nilai persatuan antar-sesama santri. Penelitian ini menggunakan pendekatan kualitatif deskriptif dengan jenis penelitian lapangan. Adapun metode pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Data tersebut kemudian dianalisis dengan reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian ini menunjukkan, pertama, proses internalisasi nilai-nilai tasawuf melalui nilai Ilahi dan nilai insani di Pondok Pesantren al-Amien Prenduan; kedua, bahwa faktor pendukung dalam internalisasi nilai tasawuf melalui upaya pendampingan pendidikan selama 24 jam dan suri tauladan yang baik oleh para kiai dan para guru. Sedangkan faktor penghambat internalisasi tersebut antara lain para santri masih banyak yang melanggar disiplin pondok dan karena latar belakang keberagaman suku yang berbeda-beda baik dari Jawa, luar Jawa atau bahkan dari luar Indonesia.Sufism is a science that prioritizes human beings in order to have the cleanliness of the soul and spirit. The boarding school of al-Amien Prenduan instilled the values that exist in the science of Sufism. The goal is for the students to always obey the command of Allah Almighty and have the values of unity among fellow students. This study uses a descriptive qualitative approach to the type of field research. The data collection method uses observation, interview and documentation. Then the data is analyzed with data reduction, data presentation and conclusion withdrawal. The results of this study show that: 1) the process of internalization of the Sufism values in boarding schools through divine values and human values; 2) supporting factors in internalizing the value of Sufism with the assistance and education for 24 hours and good suri tauladan from the kiai and teachers. While the inhibitory factor is among the students are still many who violate the discipline of the cottage and because of the background of the diversity of different tribes both from Java, outside Java or even outside Indonesia.
Tingkat keberhasilan inseminasi buatan (IB) berdasarkan Program Sapi Induk Wajib Bunting (SIWAB) di Kecamatan Sangkub
Authors: Mahyun J.C. , Poli Z. , Lomboan A. , Ngangi L.R.
Published: May 2021

ARTIFICIAL INSEMINATION (AI) SUCCESSFUL RATE UNDER THE MANDATORY PREGNANT CATTLE PROGRAM (SIWAB) IN SANGKUB REGENCY. This type of research is an explanatory research survey, explaining the successful rate of AI through the compulsory pregnancy cows (SIWAB) program in Sangkub District, Bolaang Mongondow Utara Regency. The purpose of the survey is to collect some data through interview measurement tools. The types of data in this study were the primary data and secondary data. Primary data were collected directly from respondents. The sample selection was determined purposively involving breeders who had productive female cows in Sidodadi, Pangkusa and East Sangkub villages as many as 30 respondents. The primary data technical application consist of several ways, including questionnaires, interviews, and observations. The results showed that the level of trust in the AI based on the SIWAB program in Sangkub Regency, mainly response of breeders to AI technology was very good with evidence of their participation in including productive cows in the SIWAB program. Whereas for acceptors / female cows participating in the SIWAB program in Sangkub Regency, mainly female cows showed 66 head productivity. For Service per Conception variable on 66 cows included in the SIWAB program produced 58 cows of one service of AI and 8 heads of two services of AI obtaining 1.12%. From the total number of cattle included in the SIWAB (IB) program in Sangkub Regency, the 66 cows were successfully pregnant and gave birth of 66 calves. Based on the analysis and results discussion, it can be concluded that generallyl the Breeder Response, Service per Conception, Conception Number, and ABL to the SIWAB program in Sangkub District were included in the good category.Keywords: Beef cattle, artificial insemination, compulsory pregnancy cows, Sangkub district.
Peran penyuluh peternakan dalam peningkatan pendapatan anggota kelompok peternak babi di Kecamatan Tompaso Barat Kabupaten Minahasa
Authors: Kogoya Y , Lenzun G D , Wantasen E
Published: May 2021

THE ROLE OF ANIMAL HUSBANDRY EXTENSION IN INCREASING INCOME OF PIG FARMER GROUP IN WEST TOMPASO DISTRICT, MINAHASA REGENCY.This study aims to see how the responses of farmers to the role ofextension workers in increasing the income of pig farming in Kamanga Village, West Tompaso District, Minahasa Regency. The data sources are primary and secondary. Observation and interview data collection methods. The population of breeders who raise pigs and the number of samples taken are members of the Kamanga Village hog farming group who have received guidance from the Minahasa District Agriculture, Animal Husbandry and Plantation Agency. Result study showed that extension officer from the agricultur and livestock  service have a major role  in increasing of income of pigs breeders in Kamanga village , Tompaso Sub District
Pengaruh tingkat kepadatan tanaman terhadap pertumbuhan Sorgum Brown Mid Rib (BMR) yang diberi pupuk bokashi kotoran ayam pada kondisi ternaung
Authors: Lundeto S.W. , Anis S.D. , Kaunang W.B. , Sumolang C.I.J.
Published: May 2021

THE IMPACT OF PLANT’S DENSITY ON THE GROWTH OF SORGHUM BROWN MID RIB WITH CHICKEN MANURE FERTILIZER IN AN ELEVATED STATE. The purpose of this research was determines growth of sorghum BMR with different population density use chicken manure fertilizer in an elevated state. This experiment was conducted using Completely Randomized Design (CRD). The treatment consisted of four planting density, (P1=(1 plant/Polybag) P2=(2 plants/polybag) P3=(3 plants/polybag) P4=(4 plants/polibag), each treatment had seven replications. Data were analyzed using analysis of variance and HSD test. The variables measured were growth that are plant’s height, leaf length, and number of leaves. The results showed that different planting population were significant different (P<0.01) on plant’s height, leaf length, and number of leaves. HSD test showed that planting population P1=(1 plant/Polybag) were significant (P<0.01) have higher plant’s height, leaf length, and number of leaves than P3=(3 plants/polybag) and P4=(4 plants/polybag). It can be concluded that planting density P1=(1 plant/Polybag) have the highest growth of sorghum BMR that were highest plant’s height, leaf length, and number of leaves.