bluuebunny/crossref_metadata_2025 huggingface dataset:
Cuestionario de Redes Sociales y Sentimiento de Soledad. Preliminar.
Authors: Pedrero-Pérez Eduardo J. , Haro León Agustín , Martínez Josselyn Sevilla , Zubiaur Elena Díaz
Published: April 2024

The use of social networks has been increasing in recent years, and with it the studies that relate them to various positive and negative aspects, including the influence it has on the feeling of group association or, conversely, the feeling of unwanted loneliness. The following study is aimed at creating a psychometrically adequate tool to assess the relationship between the use of social networks and the feeling of unwanted loneliness. With an initial sample of 500 participants, a questionnaire was created with a total of 11 items that, in addition to assessing the relationship between both variables, includes items from the Perceived Stress Scale and the Coping Styles Questionnaire. The results have shown that it is a valid and reliable questionnaire, with optimal values in terms of internal consistency, structure and replicability. Likewise, the conclusions drawn are congruent with other similar research, concluding that the feeling of unwanted loneliness and the use of social networks is related, although the direction of this relationship cannot be conclusively determined.
Fact or fiction? Examining the veracity of common myths relating to 7-meter throws in handball
Authors: Laxdal Aron Gauti , Byrkjedal Per Thomas , Ivarsson Andreas , Sigurgeirsson Ólafur , Haugen Tommy
Published: April 2024

There are several long-standing beliefs that persist in sport despite little or no evidence of them being true. The aim of this study was to assess the veracity of two such beliefs related to 7-meter throws in handball: 1) that the fouled players should not take their own 7-meter shots as their ability to score is compromised, and 2) that changing the 7-meter shooter after a miss is more likely to lead to a goal than letting the player who missed try again. To assess the veracity of these beliefs 8,759 7-meter shots from the Icelandic elite division were analysed using a Bayesian three-level analysis. The results revealed that neither taking your own 7-meter shot after being fouled nor taking a 7-meter shot after missing the attempt appeared to have a negative effect on the outcome of 7-meter shots.
Assessing language in infants with an elevated likelihood or diagnosis of autism: The association between parent- versus researcher-administered measures
Authors: Belteki Zsofia , Ward Emma Kate , Begum Ali Jannath , van den Boomen Carlijn , Bölte Sven , Buitelaar Jan , Charman Tony , Demurie Ellen , Falck-Ytter Terje , Hunnius Sabine , Johnson Mark Henry , Jones Emily J.H. , Oosterling Iris , Pasco Greg , Pijl Mirjam , Radkowska Alicja , Rudling Maja , Tomalski Przemyslaw , Warreyn Petra , Junge Caroline , Haman Ewa
Published: April 2024

Purpose: Infants later diagnosed with autism typically have smaller vocabularies than their peers. The MacArthur-Bates Communicative Developmental Inventory (CDI) and the Mullen Scales of Early Learning (MSEL) are key tools for assessing infants' language abilities, but it remains unclear what the association is between these measures in infancy, and whether associations vary with group status (elevated likelihood of autism or not; confirmed diagnosis of autism or not).Methods: We analyzed data from 720 14-month-old infants in the Eurosibs consortium, looking at whether the correlation between CDI and MSEL was influenced by group status (elevated likelihood of autism or not; confirmed diagnosis or not) and native language. We also compared vocabulary sizes between the two likelihood groups, and then between the two diagnostic groups.Results: Moderate correlations between CDI and MSEL scores were found across most groups, rs = [.34, .58]. Infants with an elevated likelihood of autism showed a slightly higher correlation in expressive language scores than typically developing children. Diagnosed children had smaller vocabularies than their non-diagnosed counterparts on both CDI and MSEL. The elevated likelihood group had smaller vocabularies on MSEL but not on CDI when compared to typical likelihood peers.Conclusion: The moderate associations between CDI and MSEL suggest they may measure different aspects of language in infancy, as these associations are weaker than previously reported for older children. Vocabulary size differences were more pronounced in diagnostic groups than in likelihood groups. Further research is needed to understand why these associations are lower in infants. Keywords: Language assessment, Communicative Developmental Inventory, Mullen Scales of Early Learning, Autism, Infants
Programming The Mind – The Seven Dimensions of Attachment in Personality and Psychopathology
Authors: Gagliardi Marcantonio
Published: April 2024

This book presents an innovative, comprehensive theoretical framework for Clinical Psychology: The MAPP – Mind Architecture, Personality, and Psychopathology. Through a cognitive-evolutionary perspective, the theory builds the common ground necessary to integrate the different and valuable contributions from all schools and orientations in Clinical Psychology. Moreover, the engineering approach embraced by the MAPP offers a methodological direction through which such contributions can be further developed. The focus is on the individual psychological differences caused by the information stored in a standard, organically healthy brain substrate. As its name suggests, the theory is divided into the following three parts.1. An architecture of the mind (and motivational systems), which provides a general model of its structures and functions consisting of a multitude of interconnected modules. Motivational and data systems are the central part of the architecture, and the attachment motivational system and data module play a pivotal role in human psychology.2. A model of personality according to which attachment is at its core. Attachment theory is revised and extended, identifying seven attachment dimensions – disorganization, avoidance, ambivalence, phobicity, depressivity, somaticity, and obsessivity – acquired through imprinting in attachment-caregiving interactions. We are biological machines programmed by our caregivers.3. A Model of (behavior and) psychopathology. The outlined models of motivation and personality underpin a new model of behavioral dynamics and mental disorders. Psychopathology is characterized by a central causal chain: negative social relationships cause dysfunctional knowledge to be acquired, and this knowledge causes mental disorders. The most common pathologies stem from attachment dimensions. By clarifying their etiology, the model allows for a deeper understanding of mental disorders and the development of more effective assessment tools and treatments.Finally, the MAPP is tested through the discussion of ten complex case studies inspired by the literature.Overall, the MAPP provides a novel theoretical framework for Clinical Psychology that empowers the discipline to overcome its current principal limits with a significant impact on assessment and treatment. The theory is particularly suitable for Artificial Intelligence applications and the development of automatic assessment tools.
Testing Location Invariance of the Flashed Face Distortion Effect
Authors: Chung Yong Hoon , Sosa Nicole C. Anaya , Störmer Viola S.
Published: April 2024

Spatially aligned faces presented in a continuous stream in the periphery appear distorted and grotesque. This flashed face distortion effect (FFDE) was first reported over 10 years ago, yet little is known about the underlying mechanisms. Here we investigate whether the FFDE persists across visual field locations when there is a switch in position. Face streams were presented at one location for several seconds and then either remained at the same location, or were shifted to a new location, either within the same visual half-field (Exp. 1) or across half-fields (Exp. 2). We assessed the perceived illusion magnitudes continuously throughout each trial using a joystick as a response device and found that the illusion decreased significantly when the location changed. In a third experiment we added a control condition that do not elicit an illusion and found that the decrease in reported distortions for location-shift trials was of the same magnitude as this baseline condition. Together, our results suggest that the FFDE may be bound to retinotopic locations, at least when location changes are relatively large.
Preaching to the Choir? Awareness of "Christian Nationalism" and Implications for Public Sociology
Authors: Perry Samuel
Published: April 2024

Media attention to “Christian nationalism” has grown in the past few years. Yet given that those initially using the term have largely been academic social scientists and journalists warning about it, it is quite likely that public awareness of the term itself has been concentrated among audiences (and alternatively missing others) who hold theoretically predictable characteristics. Empirically, this study examines what factors predict exposure to the term “Christian nationalism” among the general public in two national surveys. Building on research documenting growing conservative skepticism toward academics (sociologists often the focus) and siloed media consumption, I theorize Americans most familiar with “Christian nationalism” would be those who are more educated, less religious, and on the partisan and ideological left. Drawing on two representative surveys fielded in mid-September and November/December of 2022, findings affirm the strongest predictors of Americans hearing/reading more about “Christian nationalism” were being more liberal, educated, and (in one survey) being non-Christian. Also, in both surveys, interactions show exposure to the term among liberals and Democrats increases substantially with educational attainment. Despite the considerable amount of sociological research that has been conducted on “Christian nationalism,” and even apparent efforts to engage in “public sociology” on the topic, those most aware of the term in late 2022 were secular, educated, liberal, Democrats; that is, the audiences already likely to view it as threatening. I conclude by discussing implications for sociology’s public impact as a discipline.
„Kontrolle ist besser....“–wie werden die Dienstleister für die Zentralen Unterbringungseinrichtungen (ZUEn) für Geflüchtete kontrolliert?
Authors: Nienhüser Werner
Published: April 2024

These are working papers.
Falling Trust, Expertise, and Appeal: Americans' Changing Views on Clergy
Authors: Perry Samuel
Published: April 2024

This essay is an analysis of the shifting context of clergy work. More specifically, this paper is concerned with how Americans’ views of clergy are changing in consistent directions and how those changes inevitably influence the job itself―its general perception, its breadth of influence, and the pool of candidates who will likely be interested in such work. Taken together, the trends suggest a weakening foundation undergirding the authority and influence of American clergy and suggest a further diminishing population of pastors and priests eager to follow that call.
Coming to Terms With the Psi-Trickster
Authors: Kennedy James E
Published: April 2024

The trickster concept has been proposed as a useful description of paranormal phenomena in response to nine decades of inconsistent experimental results and the inability to develop sustained practical applications of psi. However, the trickster of mythology is too diverse and ambiguous for scientific research. The term ‘psi-trickster’ is used here to refer to an active factor that makes psi effects inconsistent and unsustainable but can be investigated scientifically. My transition from optimism about psi experiments to reluctantly accepting the psi-trickster is described. The primary purpose of this essay is to describe strategies and options for research given the apparent psi-trickster. Strategies for dealing with the psi-trickster include: (a) hope that continued experimental research will overcome it; (b) accept the far-reaching implications of the usual assumptions for psi experiments and develop models of unconscious conflicting psi influences by many different people; (c) investigate the possibility that reliable psi effects occur in rare conditions, such as after many years of intense meditation practice; (d) propose physics-based models; and (e) consider that factors other than the motivations of living persons may be involved. Experimental psi research has the ultimate goal of converting psi to technology. Like other technologies, the most advanced development will be for military uses and for corporate profits. Spontaneous psi experiences tend to inspire a sense of meaning in life and a belief that the person’s life is watched over, similar to mystical and near-death experiences. The psi-trickster characteristics prevent psi from being converted to technology and preserve its mysterious, mystical aspects. An in-depth investigation is needed to understand how paranormal beliefs and experiences affect a person’s life and society as a whole. This is the first step in investigating the psi-trickster characteristics and should include the distribution of beliefs in the population for the full spectrum from skeptics to proponents.
India-Nepal relations after independence (1947-2000): General Analysis
Authors: Singh Vishal
Published: April 2024

After India's independence, a new era began in India-Nepal relations. The Nepalese administration was well aware of the fact that Indian cooperation in the political, social, cultural and economic fields is essential for Nepal's independent existence and its economic progress. He was also realizing that many Nepalese leaders had helped the Indian leaders a lot by taking active part in the Indian independence movement to end the British rule and in this context, with the help of the Indian national leaders, the Nepali National Movement was being formed in India itself. Congress was born.

Abstract in Hindi Language: 

भारत की स्वतन्त्रता के पश्चात भारत-नेपाल सम्बन्धों में एक नये युग का आरम्भ हुआ। नेपाली प्रशासन इस तथ्य से भलीभांति परिचित था कि नेपाल के स्वतन्त्र अस्तित्व और उसकी आर्थिक प्रगति के लिए राजनीतिक, सामाजिक, सांस्कृतिक तथा आर्थिक क्षेत्र में भारतीय सहयोग अत्यन्त आवश्यक है। उन्हें यह भी आभास हो रहा था कि भारतीय स्वतन्त्रता आन्दोलन में ब्रिटिश सत्ता को समाप्त करने के लिए अनेक नेपाली नेताओं ने सक्रिय भाग लेकर भारत के नेताओं की काफी मदद की थी और इसी परिप्रेक्ष्य में भारत के राष्ट्रीय नेताओं की सहायता से भारत में ही नेपाली राष्ट्रीय कांग्रेस का जन्म हुआ था।

Keywords: भारत, नेपाल, पारगमन, रणनीतिक, संबंध।
India in Emerging World Order: An Asian Centric Approach to “Going Global Strategy”
Authors: Rout Suryakanta
Published: April 2024

India's rise in the global arena, particularly within the context of an emerging multipolar world system, is a subject of profound interest and analysis. This paper explores India's strategic initiatives and diplomatic maneuvers through an Asian-centric lens, focusing on key areas of study that illuminate its trajectory towards global prominence. Firstly, it focuses to India's burgeoning influence in Asian countries, tracing the evolution of its relationships and partnerships as it navigates the complexities of a multipolar world. Through strategic alliances and economic cooperation, India has positioned itself as a pivotal player in shaping the dynamics of regional and global affairs. Secondly, it examines India's Maritime Security Strategy encapsulated in the SAGAR Doctrine (Security and Growth for All in the Region), which underscores India's commitment to fostering stability, security, and prosperity in the Indian Ocean region. This doctrine represents a proactive approach towards safeguarding maritime interests and promoting cooperative security measures in the Indo-Pacific. Thirdly, the paper explores India's strategic engagement with the Indian Ocean Rim Association (IORA) in the maritime sector, emphasizing its commitment to enhancing maritime security, trade, and connectivity among member states. India's proactive involvement in IORA reflects its broader vision of fostering a secure and prosperous maritime domain in the Indian Ocean region. In fourth, it investigates India's "going global" strategy within the framework of BRICS highlighting its efforts to strengthen multilateral cooperation and promote shared development agendas. Through BRICS, India aims to amplify its voice on the global stage and forge synergies with like-minded nations. In fifth, part the paper explores India's global economic strategic framework, particularly focusing on the India-Middle East Economic Corridor (IMEC), delineating its significance in enhancing economic ties and energy security between India and the Middle Eastern nations. Finally, the paper analyzes India's innovative use of fintech diplomacy, particularly through the Unified Payments Interface (UPI), to enhance international economic inclusiveness. It also addresses the challenges hindering India's seamless integration into the multipolar world and offers recommendations to optimize its strategic pursuits. Ultimately, the research underscores the significance of an Asian-centric approach in shaping India's trajectory on the global stage and fostering cooperation with regional and global partners.
Unpacking the Dynamics of Internal Migration in India: A Focus on Government Initiatives and Girl Child Migrants
Authors: Nair Amrutha S
Published: April 2024

Migration is a process and an event. This paper tries to discuss the rights that often get disturbed while on the move. It also discusses the challenges involved thereof while relocating. Establishing a linkage between migration and education, the paper tries to cover the challenges faced by migrant children in the face of this whole process of migration and how it effects not only the education system of our country, but the very manpower that are its real strength.
Social, Cultural, and Economic Wellbeing of Educationally Deprived Children of Lucknow City
Authors: Yadav Sanjay Kumar , Vashishtha U. C.
Published: April 2024

When it comes to accomplishing personal and social goals, education is an essential tool. The quality of life is improved, equality is promoted, and various chances for social participation are enhanced via education. Since gaining its independence, India has remained steadfast in its commitment to the democratic ideals of brotherhood, equality, and justice. Providing widespread access to high-quality primary education is central to its mission to achieve educational objectives. This study investigates the status of the social, cultural, and economic wellbeing of educationally deprived children in Lucknow. In this research, we looked at how children dealing with problems like poverty and lack of school resources are doing. Essential elements in developing a feeling of belonging and identity include cultural customs and a stable and loving familial environment. However, financial constraints and a lack of formal education were significant obstacles. Despite everything, the study highlighted the children’s natural qualities, such as their inquisitiveness, generosity, and ingenuity. According to the results, programs that assist families, respect cultural identity, reduce educational inequalities, and build on children's abilities should be prioritised.
The Authority of the Notary Supervisory Board in the Position as a Body or Official of the State Administration in Imposing Administrative Sanctions on Notaries
Authors: Noorcholish Fu’ad M , Husni H. Lalu , Hirsanuddin Dan
Published: April 2024

The purpose of this research is to analyze the authority of the Regional Supervisory Board in carrying out its duties as a State Body or Official, as well as to analyze the appropriate forms of administrative sanctions that can be imposed on notaries. The results of this study indicate that the Notary Supervisory Board is a State Body or Official because it is an extension of the authority of the Minister of Law and Human Rights obtained through delegation and attribution stemming from the Notary Office Law. The decisions of the Notary Supervisory Board can be categorized as State Administrative Decisions. A Notary who violates the provisions of Article 16 paragraph (1) letter of Law Number 2 of 2014 concerning Amendments to Law Number 30 of 2004 concerning Notary Positions, will be subject to administrative sanctions based on Article 16 paragraph (11) of Law Number 2 of 2014 concerning Amendments to Law Number 30 of 2004 concerning Notary Positions which regulates that "Notaries who violate the provisions referred to in paragraph (1) letter a to letter l may be subject to administrative sanctions in the form of a written warning, temporary suspension, honorable dismissal or dishonorable dismissal." In Article 85 of the Notary Law, 5 (five) types of administrative sanctions are mentioned: verbal warning, written warning, temporary suspension, honorable dismissal, and dishonorable dismissal.
Analysis of clinical and anatomical characteristics of road transport injuries in the conditions of a rural location. Anatomical verification of damage
Authors: Guryev S. O. , Kushnir V. A.
Published: April 2024

Annotation. Road traffic injury remains one of the main causes of injury and disability not only in Ukraine, but also in the developed countries of the world. Objective – to verify and determine the clinical and anatomical characteristics of traffic injuries in victims in rural areas. The study was conducted in the order of an epidemiological experiment on a natural type model, which was formed in accordance with the law of large numbers and has typical features of the rural areas of Ukraine, the array of the study consists of 315 cases of victims as a result of traffic accidents, which exceeds the estimated volume of the necessary. The analysis of the actual material is done using the laws of formal logic, methods of parametric, non-parametric and factor statistical analysis using the computer program STATISTICA. As a result of the study, it was established that in the general array, head and neck injuries are most common (94.60%), chest injuries are the second most common (63.17%), limb injuries are the third (53.33%), and abdominal trauma is the least common (11.11%). In addition, in the general array of the study, the highest mortality rate was recorded in victims with injuries to the pelvis and abdomen (54.55% and 40.00%, respectively). Among all road users, the cranial component is the most common, with an index above 90%. Among all road users, thoracic injuries with a rate above 60% (60.53% - 68.63%) are in second place by specific gravity, and limb injuries are in third place with 47.30% - 56.86%. Abdominal injuries are the least common among drivers – only 5.88%, passengers have the least common pelvic injuries (10.81%), and pedestrians also have the least common abdominal injuries (10.00%). There are typical injuries for drivers – damage to the chest due to a steering wheel injury, for passengers – abdomen and chest, for pedestrians – damage to the abdomen, pelvis, limbs. Thus, among victims of traffic accidents, the head is most often injured in the general massif – 94.60%, the chest – 63.17%, and the limbs – 53.33%. Road traffic injury in rural areas is multi-component, on average, victims receive 2.56 injuries, and this indicates a significant impact of the traumatic agent. In road accident victims, the outcome of the course of the traumatic process depends on the specifically damaged anatomical and functional site (AFS) and moderately depends on the combination of injuries (the combination coefficient is 2.55 for survivors and 2.57 for those who died. The fatality rate in road accident victims probably depends on the damage to a specific AFS, the highest fatality rate was recorded in victims with a pelvic injury of 57.14%.
Microbiological study of the influence of an immunomodulator on the antimicrobial activity of the decametoxin antiseptic agent with their combined application
Authors: Khimich O. S.
Published: April 2024

Annotation. The article presents the results of a microbiological study of the immunomodulator “Blastomunyl” on the antimicrobial activity of the antiseptic decamethoxine in combined use. A microbiological study of the antimicrobial activity of decamethoxine in the presence of different contents of blastomunil was carried out by the macromethod of serial dilutions: sample 1 – contained 0.6 mg of blastomunil in 4 ml of decamethoxine solution, sample 2 – contained 0.6 mg of blastomunil in 8 ml of decamethoxine solution, sample 3 – 0, 6 mg of blastomunil in 10 ml of decamethoxine solution. The antimicrobial activity of the studied samples was studied against reference strains S. aureus ATCC 25923, S. aureus ATCC 29213, E. coli ATCC 25922, E. coli ATCC 35213, K. pneumonie ATCC 700603, P. aeruginosa ATCC 27853, as well as against clinical strains conditionally -pathogenic microorganisms of the Museum of Live Cultures, Bacteriological Laboratory, Department of Microbiology, National Pirogov Memorial Medical University, Vinnytsya, which were isolated from patients with wound purulent-inflammatory diseases (S. aureus (n=17), E. coli (n=17), P. aureginosa (n=17), K. pneumoniae (n= 17), A. baumannii (n=17)). A comparative assessment of the sensitivity of microorganisms to the studied drug samples was carried out according to MBsC and MBcS (in μg/ml of decamethoxine) in comparison with the corresponding indicators of sensitivity to the control solution of 0.02% decamethoxine (decasan). The integrated system STATISTICA® 5.5 (Stat Soft® Snc, USA), license number АХХР910A374605FA, was used to perform statistical calculations. The significance of the difference was determined using the Student's t-test and the Mann-Whitney U-test. As a result of the study, it was established that the combination of blastomunil solution in the amount of 0.3 mg/ml with 0.02% solution of decamethoxine has a certain antagonistic effect, which is accompanied by a significant decrease in the bacteriostatic (p<0.01) and bactericidal (p<0.001) properties of decamethoxine regarding Staphylococcus aureus. At the same time, when creating a composite agent with complex therapeutic properties, it is optimal to use 0.15 mg/ml blastomunyl and 0.02% decamethoxine solution, which provides effective anti-staphylococcal antimicrobial action and additional biologically active therapeutic properties.
Correlations of the upper respiratory tract cephalometric parameters in ukrainian young women with a very wide face type
Authors: Kostiuchenko-Faifor O. S. , Shayuk A. V. , Perlova A. V. , Vakhovskyi V. V. , Glushak A. A. , Poberezhets O. L. , Bogomaz O. V.
Published: April 2024

Annotation. The relationship between craniofacial parameters and features of upper respiratory tract indicators is the subject of research for a wide range of scientists of various directions, which is connected with the multifaceted practical significance of the possible results obtained. One of the most important directions among these studies is the study of the normative indicators of the respiratory tract, depending on various variables, because understanding the values of the norm allows us to judge pathological changes in the future. The purpose of the study is to establish the peculiarities of correlations of cephalometric parameters of the upper respiratory tract in practically healthy Ukrainian young women with an orthognathic bite with a very wide face type. A cephalometric analysis of the upper respiratory tract, soft palate, hyoid bone, and tongue was performed on primary lateral teleroentgenograms of practically healthy young Ukrainian women with a very wide face type with an orthognathic bite. The evaluation of the correlations of these indicators was carried out in the "Statistica 6.0" license package using Spearman's non-parametric statistics. In young women with a very wide face type, the following multiple reliable and medium-strength unreliable correlations were established: direct strong (r= from 0.64 to 0.76) and medium-strength (r= from 0.33 to 0.57) correlations between almost all cephalometric characteristics of the upper respiratory tract itself ways; inverse moderate strength and strong (r= from -0.30 to -0.60), as well as direct moderate strength and strong (r=0.37 and r=0.90) correlations between almost all indicators of the soft palate; direct strong (r=0.74) and medium strength (r=0.51) correlations between almost all tongue indicators; mostly direct, medium strength (r= from 0.30 to 0.45) correlations between the value of the PM-UPW distance and most indicators of the soft palate; mainly strong (r= from 0.33 to 0.72) correlations between the value of the PM-U distance and with all characteristics of the tongue, as well as the average strength, there are inverse (r=-0.33 and r=-0.52) correlations between the value of the NL/PM-U angle and most of the characteristics of the tongue; direct strong and medium strength (r= from 0.46 to 0.67) correlations between the value of the AH-FH and AH-MP distances and most of the characteristics of the tongue. Thus, the most pronounced connections are established between the cephalometric characteristics of the upper respiratory tract itself, between the characteristics of the soft palate, between the characteristics of the tongue, as well as between the cephalometric characteristics of the hyoid bone and the tongue and between the characteristics of the soft palate and the tongue.
Phleboprotective effect of Saponaria officinalis herbs extract under conditions of experimental venostasis
Authors: Tsubanova N. A. , Voloshchuk N. I. , Zastryzhna M. L.
Published: April 2024

Annotation. Chronic venous insufficiency has held the leading positions for the last 50 years in the general list of human diseases and has a significant specific weight in the group of cardiovascular pathologies. The number of drugs with phleboprotective effect on the pharmaceutical market of Ukraine and the world is extremely limited. Medicinal plant raw materials with venoconstrictor, antioxidant action and the ability to prevent blood clots can be considered as a promising object as a new phleboprotective medicinal product. The aim of this work was to study the effect of Saponaria officinalis herb extract under conditions of experimental venostasis. Experimental male rats weighing 180-220 g were simulated venostasis by placing a ligature on the tail vein. The dynamics of tail volume increase during 6 hours and the involution of edema after 1, 2, 17 and 24 hours were recorded, as well as blood coagulation time, prothrombin and thrombin time were determined. The researched extract of the common soapwort herb (ECSH) was administered intragastrically at a dose of 20 mg/kg. The comparison drug Eskuvit at a dose of 7.2 mg/kg according to escin. Statistical analysis was performed using descriptive statistics using Microsoft Excel and the Statistica 6.0 package. Convergences were considered favorable at p≤0.05. It was established that the therapeutic and prophylactic administration of ECSH at a dose of 20 mg/kg probably reduces the clinical indicators of transudative edema, which developed as a result of acute venostasis. Administration of ECSH normalizes indicators of general blood coagulation to the level of physiological limits. Therefore, the therapeutic and prophylactic administration of ECSH at a dose of 20 mg/kg during experimental venostasis with transudative edema and increased thrombus formation exerts a powerful phleboprotective effect, which statistically significantly exceeds the effectiveness of the comparison drug Eskuvit. Further studies of anti-inflammatory, membrane-stabilizing, antimicrobial and reparative activity will allow forming the pharmacological profile of ECSH as a potential phleboprotective drug.
The state of cellular and humoral immunity in patients with purulent complications of the diabetic foot and the development of sepsis in them
Authors: Shapoval S. D.
Published: April 2024

Annotation. The purpose of the study was to find out the disorders of the specific immune system of the body in patients with DFS and in the case of complications of the disease with sepsis. Materials and methods. 1627 patients were examined for complicated DFS, in which in 4.1% of cases (67 patients) the disease was aggravated by sepsis. All patients had type II diabetes and were treated in the city purulent-septic center with beds for the diabetic foot of the CNPE “City Hospital № 3” in Zaporizhzhia for the period 2007-2022. The criteria for inclusion in the study were: purulent-necrotic processes of a diabetic's foot and cases when the disease was complicated by the development of sepsis. Exclusion criteria: type I diabetes and patients undergoing hemodialysis. Statistical analysis was performed using the “Statgraphics Plus for Windows 7.0” software package. The state of the T-cell system based on the derived formula of immune disorders was as follows: CD3+1- CD4+1- CD8+1+ CD25+1+, which is qualified as the 1st degree of immunological disorders of cellular immunity. On the 7th to 8th day of treatment of patients with DFS, the formula of immune disorders was as follows: CD3+2-CD4+2-CD8+1-CD25+1-, which indicated a disorder of the immune system of the II degree, and on the 12th to 16th day - CD3+1 - CD4+1- CD8+1- CD25+1+, which indicated the transition of the immune system disorder from II degree to I. In CDS patients whose disease was complicated by sepsis, the content of CD3+, CD4+, CD8+ at hospitalization was reliable (P < 0,05) was lower than in patients without sepsis. The results of the study of the cellular link in patients with sepsis can be represented by the formula: CD3+2- CD4+2- CD8+1- CD25+2-, which indicates an immune disorder of the II degree. The formula of immune disorders of the cellular link in patients with sepsis on the 7th - 8th and 12th - 16th day of the postoperative period indicated that the suppression of the cellular link corresponds to the II degree of immune disorders. The state of humoral immunity in patients with purulent-necrotic processes of the diabetic foot during hospitalization was as follows: Ig A1- Ig M1- Ig G1- CD221-, which indicated the first degree of immunological disorders, while in patients with sepsis - Ig A-1 Ig M3+ Ig G3+ CD22+1+. Similar changes in the latter corresponded to the II degree of immune disorders. On the 7th - 8th and 12th - 16th days, the formula of immune disorders was as follows: Ig A2- Ig M1- Ig G1- CD222-, which corresponded to the II degree of immune disorders. In patients with sepsis, during the same period of the study, an immune disorder of the II degree was observed, but the formula was as follows: Ig A1- Ig M1- Ig G1+ CD22+2-. Thus, the state of the cellular and humoral links of the immune system in patients with both purulent-necrotic processes of DFS and with the development of sepsis is qualified as general immune depression.
Analysis of management tactics of patients with acute noncalculous cholecystitis in combination with coronavirus disease
Authors: Pokidko M. I. , Hutsol V. V. , Katsal V. A
Published: April 2024

Annotation. The purpose of the study is to analyze the results of treatment, the frequency of complications and the general course of the disease of patients with acute noncalculous cholecystitis with concomitant acute respiratory infection SARS-CoV-2, to investigate the etiopathogenetic relationship of these pathologies. The results of treatment of 27 patients with acute noncalculous cholecystitis and concomitant coronavirus disease in the period from 2021 to 2023 were analyzed. Among them, 18 (66.6%) were women and 9 were men (33.4%). The diagnosis of acute cholecystitis was established according to the Tokyo Guidelines (Tokyo Guidelines 2018), coronavirus disease using polymerase chain reaction (PCR). The patients underwent physical examinations, a full range of laboratory tests, instrumental ultrasound diagnostics of abdominal organs, and histological examination of postoperative material. It was found that 27 patients (100%) had non-calculous forms of acute cholecystitis. 20 patients (74.1%) received surgical intervention as a method of treatment for acute noncalulosis cholecystitis, 7 patients (25.9%) received conservative treatment. From 20 operated patients, the results of histological examination in the form of phlegmonous changes of the bladder were obtained in 15 (75%) cases, gangrenous changes in 5 (25%) cases. Minimally invasive technique in the form of laparoscopic cholecystectomy was used in 19 (95%) cases, open laparotomy access was in 1 (5%) case. The degree of severity according to the 2018 Tokyo Protocol was Grade I in 15 (75%) cases, Grade II in 5 (25%) cases. Postoperative complications were in 1 (5%) case in the form of eventeration. The total mortality was 0 (0%) cases. Active tactics of management of patients with acute noncalculous cholecystitis with concomitant coronavirus disease, in the form of surgical intervention, showed positive results and can be used as an appropriate method of treatment.
Analysis of the frequency of cemento-enamel junction caries in permanent teeth of different groups
Authors: Yakimovych D. V. , Masna Z. Z.
Published: April 2024

Annotation. Dental caries is currently one of the most widespread diseases globally and demonstrates a pronounced tendency to increase, despite the rapid development of dental science, modern capabilities, and medical technologies. The cemento-enamel junction (CEJ) is among the most vulnerable areas to carious processes. The aim of our study was to determine the frequency of carious lesions at the CEJ of teeth in various age groups among residents of Lviv region. The randomized group of examined patients included 200 individuals of mature age (100 men and 100 women) seeking dental care at the Department of Therapeutic Dentistry and the therapeutic department of the Dental Center of Danylo Halytsky Lviv National Medical University. CEJ caries was detected in 29.5% of the total examined population, including 32% of examined men and 27% of examined women. Among the examined individuals, 99.5% had carious cavities localized on the buccal surfaces of the teeth, while circular lesions of tooth 44 were found in 0.5% of patients. The frequency of CEJ caries in the upper and lower jaws was equal in women, while in men, it varied minimally. In men, the right side of the teeth was more frequently affected, while in women, the frequency of lesions on the right side of the upper jaw and the left side of the lower jaw was more than twice as high as the frequency of lesions on the opposite side. In men, CEJ caries most often affected the first premolars, canines, second premolars and lateral incisors. In women, the affected teeth were the first premolars, second premolars and canines. The least observed were lesions of CEJ caries in the molars. In terms of the percentage distribution of affected teeth, premolars constituted the largest proportion, while molars had the smallest share. The ratio of specific portions of affected teeth in different groups in men and women has features characteristic of individuals of each sex with asymmetry of lesions more pronounced in women.
Minimally invasive surgical treatment of combat trauma of the chest cavity (first results)
Authors: Usenko O. Yu. , Sydiuk A. V. , Klimas A. S. , Sydiuk O. E. , Savenko G. Yu. , Teslya O. T.
Published: April 2024

Annotation. The article is devoted to the study and comparison of the first results of the treatment of the wounded with combat damage to the chest cavity, which were obtained during the hostilities of 2022-2023. The aim of the study – to improve the results of treatment of the wounded with damage to the organs of the thoracic cavity, by implementing modern diagnostic and surgical methods using minimally invasive technologies and tissue viability imaging systems. All wounded (20 patients) underwent VATS surgical interventions with pleurectomy, lung decortication and resections of areas of damaged lung parenchyma. The wounded of the first group (10 patients) additionally underwent visualization control of the viability of tissues by using ICG technology with the contrast “Verday” 0.1 mg/kg of body weight and subsequent lung resection within the determined limits of viability. In the second group (10 patients), if lung resection was necessary, the selection of the resection margin was based on the surgeon's subjective assessment. In the postoperative period, the following were evaluated: the duration of artificial lung ventilation after surgical procedures, the duration of dependence on oxygen support, the presence of repeated VATS or thoracotomy operations, the presence of acute respiratory distress syndrome in adults (ARDS), pneumonia, pneumothorax, pleural empyema. Statistical analysis of clinical data on postoperative complications was carried out using the statistical analysis package EZR v. 1.35 (Saitama Medical Center, Jichi Medical University, Saitama, Japan). The Mann-Whitney test was used to analyze the differences between groups of quantitative and rank characteristics. According to indicators evaluated after operations, no significant difference between groups of patients was obtained was, however, there was a trend toward better outcomes in the patient group where ICG contrast was used to assess tissue viability and assess the extent of lung resection. The absence of a significant difference between the indicators of the two groups is due to the small sample of patients included in the study. Therefore, it is necessary to continue to investigate the use of indocyanine green (ICG) contrast technology during VATS interventions with a larger sample of patients.
Sleep disturbances in patients with systemic lupus erythematosus, connection with the course of the disease
Authors: Stepaniuk T. V. , Shevchuk S. V.
Published: April 2024

Annotation. The mechanisms of frequent and various sleep disturbances in systemic lupus erythematosus (SLE) remain largely unstudied in spite of side effects of drugs, as well as chronic stress, depressive disorders and the duration of the disease playing a certain role in their occurrence. Purpose – to assess the presence and severity of insomnia in patients with systemic lupus erythematosus and to study its relationship with the course of the disease. 96 patients with SLE were examined, the average age of which was 37.5±0.9 years, the duration of the disease was 6.2±0.4 years. The control group consists of 29 practically healthy people, the average age is 39.0±1.09. All patients were examined by a neurologist and a psychiatrist, sleep disorders were assessed by a clinical survey using the Insomnia Severity Index questionnaire. The statistical analysis of the obtained results was carried out according to generally accepted methods of variational statistics using the package of statistical programs “Microsoft Office Excel 2007”. It is established that sleep disorders in patients with systemic lupus erythematosus occur in 88.5% of patients, while in the control group this indicator is 17.2%. Mild sleep disorders were found in 20.8% of patients, moderate in 66.7%, severe in 21.8%. Most often, these disorders were manifested by interrupted sleep (55.2%), daytime activity disturbance (35.4%), difficulty falling asleep (26.0%), daytime quality of life disturbance (22.9%), early awakening (11.5%). Insomnia was not closely related to gender and disease duration, increased with age, and was more closely associated with SLICC/DI damage index and SLEDAI disease activity. So, sleep disorders in patients with systemic lupus erythematosus occur 5.1 times more often than in healthy individuals, have different manifestations and degrees, are associated with age, total SLEDAI activity index, and internal organ damage index. Early diagnosis of these disorders, assessment of the connection with the course of the disease can be of great importance in improving the quality of life of patients.
Mathematical model of diagnostics of malignant pancreas pathology
Authors: Petrushenko V. V. , Sukhodolia S. A. , Sukhodolia A. I. , Radoga Ia. V. , Rudnichenko Ye.
Published: April 2024

Annotation. Chronic pancreatitis (CP) is a common recurrent pathology of the pancreas. The long course of the inflammatory process, accompanied by chronicity, is the cause of concomitant complications of the gastrointestinal tract, and is also often attributed to the causes that lead to the development of a pathology with an extremely unfavorable prognosis – pancreatic cancer (PC). The purpose of the work is to build a mathematical model for the diagnosis of malignant pathology of the pancreas based on the available group of real statistical data in the form of symptoms of the type of presence (presence). 45 patients who were operated on between 2018 and 2022 were analyzed. A problem of automatization of diagnosing malignant pancreas pathology or its absence is considered. The goal is to build a mathematical model of diagnosing the malignant pathology based on an available group of statistical data in the form of 0 and 1, which indicate the absence and presence of the definite symptom. Based on the selected symptoms of the pathology development likelihood increase, a mathematical model in the form of binary classification is built by using probabilistic neural networks. A set of the selected symptoms is divided into a group of 14 more influential symptoms and a group of 13 less influential symptoms. A set of statistical data of 20 patients with a correctly diagnosed presence of pathology and a set of statistical data of 25 patients with a correctly diagnosed absence of malignant pathology were formed for the construction and testing of a classifier. Thus, if the number of false symptoms did not exceed five in each of the sets, then the corresponding classifier, which is an average of 20,000 probabilistic networks, determines the diagnosis without error. It is noted that the slower 53130 classifier is more reliable.
Psychoemotional response and quality of life of patients with rheumatoid arthritis: the relationship with alexithymia
Authors: Shalkovskyi Y. I. , Stanislavchuk M. A.
Published: April 2024

Annotation. In aim to study the features of the psycho-emotional response and quality of life of rheumatoid arthritis (RA) patients in the context of alexithymia, 146 RA patients were examined using the DAS-28, SDAI, CDAI, VAS, HAQ, DRI, TAS-20, HDRS, HARS, A. Beck and SF-36. RA patients showed signs of mild depression (HRDS score 9.59±7.09 points, A. Beck scale 10.04±15.00 points), and alexithymia patients showed signs of depression of moderate severity (16.72±5.79 points and 17.31±14.60 points), and in patients without alexithymia – subdepression (7.25±5.82 points and 7.66±14.41 points); and increased level of anxiety (HARS score 17.07±7.08 points), while patients with alexithymia had a significantly higher score compared to patients without alexithymia (20.08±5.86 points versus 16.08±7, 19 points, p<0.01). Correlations of moderate strength were established between depression and anxiety and clinical symptoms of the disease; moreover, in patients with alexithymia, these connections were distorted, which gives reason to consider alexithymia as a factor that distorts pathophysiological and psychopathological reactions, and distorts the connections between somatic and psychological factors in the pathogenesis of RA. In patients with RA, a decrease in quality of life was found, more significant in patients with alexithymia, according to the physical component of health (indicators in all patients 53.05±19.36 points, in patients with alexithymia 35.69±14.19 points, without alexithymia – 58.73±17.38 points, p<0.001) and the psychological component of health (57.84±18.02 points, 34.78±8.79 points and 65.38±13.19 points, respectively, p<0.001). Significant (p<0.001) inverse correlations of mainly moderate quality of life with indicators of RA activity, severity of pain syndrome, functional capacity and health status of patients, as well as with TAS-20 indicators, depression and anxiety scales in patients without alexithymia, and the absence of significant relationships for most indicators in patients with alexithymia, which indicates that alexithymia distorts the influence of clinical and psychological factors on the quality of life of patients with RA.