bluuebunny/crossref_metadata_2025 huggingface dataset:
Dataset for Vaginal Human Papillomavirus infection among adolescent and early adult girls in Jos, Nigeria
Authors: Cosmas Nanma T. , Nimzing Lohya , Egah Daniel Z. , Famooto Ayotunde O. , Adebamowo Sally N. , Adebamowo Clement A.
Published: April 2023

Objectives: To assess risk factors for HPV infection, determine knowledge about HPV vaccines, assess willingness to receive the HPV vaccine among adolescent and early adult girls in Nigeria, we administered a structured questionnaire. We also collected samples to determine the prevalence and patterns of HPV infections.
Data description: The dataset contains the responses of 205 participants from 10 randomly selected public and private secondary schools in Jos, Nigeria. The data includes information on risk factors for HPV infections such as sexual behaviours, knowledge about HPV vaccine and willingness to receive the vaccine. This is valuable information that can be compared to data from studies in other environments or to determine changes in the pattern of risk factors and HPV prevalence in this population over time.
Infinite System of Nonlinear Tempered FractionalOrder BVPs in the Spaces of Tempered Sequences
Authors: NAGESWARARAO SABBAVARAPU , Khuddush Mahammad , Msmali Ahmed Hussein , Ahmadini Abdullah Ali H.
Published: April 2023

Based on the Hausdorff measure of noncompactness and Meir–Keeler fixed point theorem in a tempered sequence space, we derive sufficient conditions for the existence of solutions via the Hausdorff measure of noncompactness (HMNC) in tempered sequence spaces to the infinite system of Tempered fractional boundary value problem (TFBVP) in the tempered sequence space
Association between suicide attempts and anemia in late-life depression inpatients
Authors: Li Jie , Wang Lan , Sun Yadi , Zhao Fengxue , Lu Ying , Yang Lei
Published: April 2023

Objective: Anemia is strongly associated with late-life depression (LLD); however, few studies have investigated the relationship between anemia and suicide attempts in LLD patients. This study aimed to compare serum ferritin, folate, vitamin B12, and erythrocyte parameter levels in patients with LLD with those in healthy older adults, and the relationship between serum ferritin, folate, vitamin B12, and suicide attempts in patients.
Methods: Serum ferritin, folate, vitamin B12, and erythrocyte parameter levels were measured in hospitalized LLD patients (n=66) and healthy older adults (n=47). All participants were surveyed for basic conditions and suicide attempts, and depression was assessed in LLD patients.
Results: Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, and hematocrit levels were significantly lower in LLD patients compared with healthy older adults (p<0.05). Further analysis of the relationship between serum ferritin, folate, and vitamin B12 levels and LLD patients’ suicide attempts and self-assessed depression scores showed a significant negative association between serum folate and vitamin B12 and suicide attempts (p<0.05).
Conclusion: Serum ferritin, folate, vitamin B12, red blood cell count, hemoglobin, and hematocrit levels were significantly lower in LLD patients than in healthy older adults. In addition, reduced serum folate and vitamin B12 levels in patients were associated with suicide attempts.
Integrated metabolic and immune profiling analysis reveals distinct prognostic signatures for neoadjuvant immunotherapy in locally advanced esophageal cancer
Authors: Lu Yuting , Liu Chunquan , Zhao Haiqing , Dong Yin , He Zhihao , Song Shuai , Cui Yong , Jin Jiangtao , Wang Ji Wang , Li Hongzhong , Li Qin
Published: April 2023

Background
There is an unmet demand for non-invasive biomarker assays to identify patients benefiting from neoadjuvant immune checkpoint inhibitors (ICIs). Here, we aimed to characterize the composition and alterations in plasma metabolites and peripheral blood immune cell subtypes associated with neoadjuvant ICI efficacy in locally advanced esophageal cancer (LAEC) and to investigate potential novel therapeutic targets and non-invasive biomarkers for predicting ICI efficacy.
Methods
89 patients with LAEC treated with neoadjuvant programmed cell death 1 blockade combined with chemotherapy were included in this study. We performed an untargeted metabolomic analysis of 606 metabolites on 72 plasma samples using high-performance liquid chromatography-mass spectrometry and an immune profiling analysis of 9 immune cell subtypes on 33 peripheral blood mononuclear-cell samples using flow cytometry. Furthermore, we conducted correlation network and pathway enrichment analyses for potentially beneficial and pathogenic metabolites to explore the metabolite-mediated ICI responses. Finally, a metabolite-based prediction model was established using the least absolute shrinkage and selection operator regression analysis.
Results
Comparative metabolomics revealed that pyrimidine and purine metabolic pathways were disturbed in ICI non-responders, with significant enrichment of dihydrothymidine, ureidoisobutyric acid, and deoxyadenosine, which were significantly associated with poor survival. Conversely, jasmonic acid increased dramatically in responders and was significantly associated with better survival. Strikingly, tryptophan metabolism intermediate-indole-3-acetic acid and arachidonic acid metabolism intermediate-16(R)-HETE levels were positively correlated with cytotoxic T lymphocyte levels but inversely correlated with polymorphonuclear-myeloid-derived suppressor cells levels, which were markedly associated with a favorable prognosis. Notably, the area under the receiver operating curve for the metabolite-based model predicting 12-month overall survival was 87.7% and 82.6% in the discovery and validation cohorts, respectively, demonstrating promising performance.
Conclusions
Our work identified potential non-invasive biomarkers based on plasma metabolic signatures for predicting neoadjuvant ICI responses and prognosis in patients with LAEC, which provides novel insight into ICI precision medicine in the management of LAEC.
Effects of Synthetic Jets on Swirl Inflow in a Variable- Geometry Twin Air-Intake
Authors: Yadav Krishna Kumar Rajnath , Paul Akshoy Ranjan , Jain Anuj , Alam Firoz
Published: April 2023

Air intakes are an integral part of contemporary passenger and military aircraft engines. Their impact on aerodynamic performance across the entire flight envelope is critical to aircraft flight safety, efficiency, and maneuverability, especially at high Mach numbers due to shock waves. The high demand for reduction in aircraft weight and size and enhancement of durability, comfort, and thermal and radar signatures compels researchers and engineers to explore new designs and develop efficient air intakes for high-performance aircraft engines. Although a number of studies on air intake have been conducted and reported in the open literature, there is little information available in the public domain on bifurcated twin air intakes using synthetic jet. As a result, the primary goal of this research is to use high-fidelity computational fluid dynamics modelling to investigate the effects of synthetic jets on swirl inflow variable geometry twin air intake aerodynamic performance over a range of Reynolds numbers. Some important parameters (distortion coefficient, non-uniformity index, swirl coefficient, and static and total pressure coefficients) were investigated. Both static and total pressure recovery have been increased at all swirl numbers. A significant decrease in distortion coefficient and swirl coefficient has also been achieved, reaching 67% in both cases. The reduction in the non-uniformity index is achieved by 62% for the controlled flow case. The findings show that the synthetic jets are effective in controlling the flow separation in the twin air-intakes and enhancing aerodynamic performance.
In-Depth, Breadth-First, or both? Characterising the information search process in a PublicTransport SP Experiment
Authors: Nova Gabriel , Guevara C. Angelo
Published: April 2023

Development and innovation in discrete choice modelling has been dominated by Random Utility Maximization approaches due to their ease of application and high economic interpretability. However, this model assumes that decision-makers perform an in-depth information search process implicitly and instantaneously. In particular, it has not been investigated in detail whether the information search process of transport users is in-depth or breadth-first in a public transport choice context, a gap that this research aims to fill. To this end, the information search process of public transport users has been characterized by stated preference surveys with click-tracking. Specifically, three pivoted SP surveys concerning morning peak trips were designed and applied, varying in the number of alternatives and attributes (areas of interest shown: AOI). These values were displayed as an information board, where only one attribute is visible at a time, and clicks were recorded to evaluate the respondents' information search process. Three main conclusions can be drawn from the findings. First, the pattern of searching for information in breadth-first predominates independently of the AOIs displayed. Second, more searches are performed than the amount of information displayed and this value increases at a decreasing rate with increasing AOIs. Third, the most likely transitions during the deliberation process are those that arise from breadth-first searches. In summary, the evidence found suggests that there is a dominance of breadth-first searches, so the RUM model would not be able to describe the deliberation process adequately and that the assumptions of the RRM or DFT models would be more appropriate for these purposes.
Central role of the habenulo-interpeduncular system in the neurodevelopmental basis of susceptibility and resilience to anxiety in mice
Authors: Rakotobe Malalaniaina , Fjerdingstad Niels , Ruiz-Reig Nuria , Lamonerie Thomas , D'Autréaux Fabien
Published: April 2023

Having experienced stress during sensitive periods of brain development strongly impacts how individuals cope with later stress. Many become more prone to develop anxiety or depression, but some appear resilient. The as-yet-unknown mechanisms underlying these differences may lie in how genes and environmental stressors interact to shape the circuits controlling emotions. Here, we investigated the role of the habenulo-interpeduncular system (HIPS), a critical node of reward circuits, in early stress-induced anxiety in mice. Based on immediate early gene expression, we found that a subcircuit of this system, characterized by Otx2 expression, is particularly sensitive to chronic restraint stress during the peripubertal period, and that this induces hypersensitivity of the HIPS to later stress and susceptibility to develop anxiety. We also show that conditional knockout of Otx2 restricted to the HIPS in mice counteracts these effects of stress. Together, these results demonstrate that a genetic factor, Otx2, and stress interact around puberty to shape the stress sensitivity of the HIPS, revealing this sensitivity as a key modulator of susceptibility/resilience to develop anxiety.
Etiology and risk factors for non-suicidal self-injurious behavior
Authors: Darin E. V. , Zaitseva O. G.
Published: April 2023

The article presents a review of the literature on the subject of non-suicidal self-injurious behavior (NSSI), the study of which attracts the attention of authors, both in the Russian Federation and around the world. Large meta-analyses of NSSP studies, proposed models, probable causes and mechanisms of occurrence, neurobiological factors, social factors, as well as the influence of modern means of communication and social networks are considered. Objective is to study, summarize and present data on the causes and risk factors of non-suicidal self-injurious behavior. Research method — articles in the “MEDLINE/PubMed”, “Scopus” databases in international medical journals were selected and analyzed. Articles were searched by keywords: “Self-Injurious Behavior”, “Non-Suicidal Self Injury”, “Deliberate Self-Harm”, “Self-Harm”, “Risk Factors”. Inclusion criteria: publication date from 2017 to 2022, clinical studies, meta-analyses and systematic reviews, randomized controlled trials, availability of the full text in the public domain or abstract. Exclusion criteria: abstracts; monographs, study guides; publication date until 2017, inconsistency with the research topic. A total of 94 publications were found. The review included 61 publications from 2017 to 2022 that corresponded to the topic and purpose of the study, and also added 19 sources older than 2017 that are significant for disclosing the subject of the study from references in the reference lists of the analyzed sources.
On some issues of medical semiotics
Authors: Volkova N. I. , Volkov A. V.
Published: April 2023

Very few works are devoted to the problem of medical semiotics, meanwhile, modern medical science, having received new research methods, expanding knowledge about diseases and the human body, continuously introduces new concepts, terms, indicators. Their integration into the general context of medical semiotics is an important problem. A significant difficulty is the large volume of symptoms, syndromes currently accumulated in medicine. This article is devoted to the transformation of empirical medical semiotics into analytical one. The authors, relying on the apparatus of theoretical semiotics, proposed a new classification of symptoms and the concept of the meaning of symptoms. These approaches make it possible to make all the array of medical symptoms available for use by a doctor and to diagnose diseases based on a logically consistent and modeling human thinking algorithm. The article outlines a further program for the improvement and development of medical semiotics.
Effect of combined antioxidant and photodynamic therapy on the emotional state of patients with vulvar craurosis
Authors: Kiseleva E. A. , Makhmutkhodzhaev A. Sh. , Mikheenko G. A.
Published: April 2023

Objective: studying of the effect of combined antioxidant and photodynamic therapy (PDT) on the emotional state of patients with vulvar kraurosis. Materials and methods: the study involved 90 women with vulvar kraurosis who were randomized into three groups of 30 participants. In the first group, treatment included photodynamic therapy (PDT) followed by administration of the antioxidant Ethylmethylhydroxypyridine succinate for one month. Participants in the second group received only PDT. Patients of the third group underwent a course of laser therapy on the perineal region. The emotional state of the participants was assessed using the Hospital Anxiety and Depression Scale (HADS) before and at the end of treatment, 1, 6 and 12 months after the end of therapy. Results: before treatment, participants from the three groups scored a similar number of HADS scores. In the course of observations, the best result on the scales of anxiety and depression was recorded in patients who received combined antioxidant and photodynamic therapy. After a month of taking Ethylmethylhydroxypyridine succinate, the HADS score in these women was significantly lower than in the comparison groups. Further, these patients continued to show better scores on the depression scale. The total scores on the anxiety scale in this group were comparable to those in patients who received only PDT. Conclusion: combined antioxidant and photodynamic therapy, including Ethylmethylhydroxypyridine succinate, has a more pronounced positive effect on the emotional background of patients with vulvar kraurosis in comparison with PDT and laser therapy.
Pathogenicity factors of Acinetobacter baumannii
Authors: Gudueva E. N. , Chemisova O. S.
Published: April 2023

Acinetobacter baumannii is a gram–negative, aerobic, oxidase-negative microorganism, a pathogen that causes serious nosocomial infections, as well as community-acquired pneumonia, especially in people with weakened immunity and multiple organ diseases, all over the world. A. baumannii survives for a long time on various surfaces, medical equipment. According to the World Health Organization (WHO), this microorganism is classified as a threat to human health. The review describes the main factors of pathogenicity of A. baumannii: outer membrane proteins, pili, LPS, capsule, siderophores, biofilm formation, secretion systems. The literature search was carried out using databases “Scopus”, “Web of Science”, “RSCI”, “MedLine”, in the period from 1992 to 2022. The selection of literature sources was carried out based on the availability of information on the study of pathogenicity factors of Acinetobacter baumannii. 60 literature sources were selected that meet the necessary criteria. The search was carried out using keywords and phrases, such as “A. baumannii”, “pathogenicity factors”, “outer membrane proteins”, “pili”, “LPS”, “capsule”, “siderophores”, “biofilm formation”, “secretion systems”. The review presents the latest achievements obtained by foreign and domestic authors. A. baumannii, like other pathogens, requires the coordinated work of various pathogenicity factors for the occurrence of infection. Together, pathogenicity factors enable the microorganism to survive in hospital conditions. Scientific research data indicate a high degree of heterogeneity of A. baumannii strains. Further research should be aimed at molecular genetic studies of the mechanisms of pathogenicity, the emergence of resistance to antimicrobial drugs. Understanding what mechanisms and factors contribute to the virulence of strains is necessary for the development of new methods of combating A. baumannii.
Evaluation of serological indicators of the presence of antibodies to pathogens of natural focal infections in the population of the Rostov region in 2021
Authors: Bereznyak E. A. , Trishina A. V. , Aronova N. V. , Pichurina N. L. , Egiazaryan L. A. , Anisimova A. S. , Simonova I. R. , Pavlovich N. V. , Kovalev E. V. , Leonenko N. V. , Novikova A. I. , Noskov A. K.
Published: April 2023

Objective: to analyze the results of blood sera comprehensive study of the local population of the RR, conducted in 2021 to assess the state of natural and zoonotic focus of CHF, WNF, ITBB, tularemia and risk of possible spread of Haemorrhagic Fever with Renal Syndrome (HFRS). Materials and methods: 424 blood serums obtained in 2021 from healthy donors living in 10 administrative territories of the Russian Federation were tested by enzyme immunoassay. Results: in 2021 the detection rates of specific antibodies in the studied areas were: WNF — 9,9 %, HFRS — 4,5 %, ITBB — 2,6 %, CHF — 0,7 %, tularemia — 22,6 %. When comparing the results obtained in 2020 and 2021, the difference in the proportions of seropositive samples is not statistically significant. Conclusions: the study of the immune layer to NFI in selected population groups confirms the circulation of pathogens in RR territory. The monitoring results demonstrate the extensive, mostly combined nosoareals of NFI of viral and bacterial etiology and the contact of the local population with them.
School reopening: Evidence-based recommendations during COVID-19 pandemic in Indonesia
Authors: Kristiyanto Raden Yuli , Chandra Lily , Hanjaya Hermawan , Hakim Mohamad Saifuddin , Nurputra Dian Kesumapramudya
Published: April 2023

Since the first Coronavirus Disease 2019 (COVID-19) case was reported, it has run amok and caused global changes. It has affected human lives in almost every aspect, including education. In response to COVID-19, governments and policy-makers decided to shift the educational activities into online learning and institute school closure. As of March 2020, many countries worldwide have implemented school closure, including Indonesia. Large scale social distancing and stay-at-home policies have begun to negatively impact society’s physical and mental health. As people start to adapt to the first wave of the COVID-19 pandemic, policy-makers and the government need to consider how to reopen the schools and its system to keep students and staff safe. School reopening is an important step toward loosening the lockdown. Schools play a crucial role in preserving children's well-being. The objective of this review was to give a recommendation to facilitate school reopening. Research articles were gathered and assessed based on the themes of the articles. Forty articles were found reflecting SARS-CoV-2 and school reopening. Findings were adapted and modified according to Indonesian situations during the SARS-CoV-2 pandemic. Indonesia is currently preparing the first steps toward school reopening. For schools to be reopened, there are several health measurements that need to be considered. A good collaboration between various authorities and stakeholders is essential in school reopening so that children’s safety and disease mitigation strategies remain stable. This review presents insights and recommendations for every element involved in school safety including the government, schools, teachers, parents and students including what each needs to do to prepare in advance for the up-coming decision to reopen schools.
Effectiveness of Helichrysum italicum Essential Oil on Wound Healing
Authors: Wijayadi Linda Julianti , Kelvin Kelvin
Published: April 2023

Helichrysum italicum essential oils (EOs) has long been known as a medicinal agent, especially in wound healing. This is inseparable from the chemical compounds contained in it, such as abundant monoterpenes and sesquiterpenes. The purpose of this systematic review is to examine various studies on the effectiveness of H. italicum EOs on wound healing. Research data searches were conducted through Google Scholar, Proquest, Science Direct, SpringerLink, Wiley Online Library, Taylor & Francis Online and PubMed over the last 10 years by following inclusion and exclusion criteria. Obtained as many as 11 studies that match the criteria. Based on the review of these studies, it was found that H. italicum EOs has good wound healing abilities when viewed from various aspects such as its chemical components, biological activity and its effect on injured body tissues. These chemical components vary in type and amount because they are influenced by various aspects. Biological activities such as antioxidant, antimicrobial, and anti-inflammatory effects have also been shown to be contained in this oil because it affects various phases of wound healing, namely hemostasis, inflammation, proliferation and remodeling phases. This is also inseparable from the accuracy of the type of vehicle used.
Optimasi Fosfatidilkolin dan Span 80 sebagai Penyusun Vesikel Transfersom Natrium Diklofenak menggunakan Design-Expert
Authors: Sitti Zubaydah Wa Ode , Suryani Suryani , Kurniawati Nur Janna
Published: April 2023

Natrium diklofenak merupakan golongan NSAID (Non Steroid Anti-Inflammatory Drugs) yang banyak diresepkan untuk inflamasi dan nyeri. Namun dalam penggunaannya secara oral, natrium diklofenak mengalami first pass metabolism di hati sehingga hanya sekitar 50% saja obat yang sampai pada sirkulasi sistemik dan jika seringkali diberikan dengan dosis yang lebih tinggi dapat memperparah efek samping di saluran pencernaan. Karena beberapa kerugian diklofenak pada penggunaan oral, maka diklofenak dikembangkan ke sistem penghantaran transdermal dalam hal ini nanovesikel transfersom yang dipilih sebagai alternatif untuk mengatasi permasalahan tersebut. Penelitian ini bertujuan untuk memformulasi vesikel transfersom natrium diklofenak dengan perbandingan (4,5%:0,5%), (4,5%:1%), (4%:0,5%) dan (4%:1%) agar diperoleh perbandingan formula optimum vesikel transfersom natrium diklofenak dengan basis fosfatidilkolin kedelai dan span 80 menggunakan design expert dan untuk mengetahui karakteristik transfersom natrium diklofenak berupa efisiensi penjerapan, distribusi ukuran partikel dan zeta potensial. Optimasi formula transfersom menggunakan metode desain faktorial 22 dengan faktor fosfatidilkolin kedelai dan span 80 menggunakan respon efisiensi penjerapan dan ukuran vesikel. Hasil dari penelitian ini yaitu formula optimum dengan konsentrasi fosfatidilkolin kedelai 4,5% dan span 80 0,5% serta pengujian karakteristik vesikel transfersom allopurinol dengan efisiensi penjerapan 99,56%, distribusi ukuran partikel 160,1 nm dan zeta potensial -57,1 mV.
IMPACT OF THE COVID-19 PANDEMIC ON CONSUMER BEHAVIOR DURING SOCIAL ISOLATION AND SUSTAINABLE CONSUMPTION: A PERSPECTIVE IN BRAZIL AND PORTUGAL
Authors: Severo Eliana Andréa , De Guimarães Julio Cesar Ferro , Soares Tiago Bedin , Ahire Kaila D.
Published: April 2023

Purpose: This study aims to analyze the impact of the COVID-19 Pandemic on consumer behavior in social isolation and sustainable consumption, from the perspective of the 2030 Agenda, given the perception of 2403 residents in Brazil and Portugal, through four research hypotheses.
Method/approach: The methodology used was quantitative and descriptive research, through exploratory factor analysis and multiple linear regression.
Main findings: The results highlight that all hypotheses were confirmed, and the most relevant relationship, that is, the most significant impact, occurred between the COVID-19 Pandemic and consumer behavior in social isolation, as well as differences in the perception of respondents between the Countries.
Theoretical, practical/social contributions: Regarding the managerial and social contributions of the research, they allow managers and health professionals to have knowledge about the impacts of the COVID-19 Pandemic, assisting them in developing strategies to face the Pandemic. In addition to information for public policies at the regional and national le’vels to support cities and regions in facing the Pandemic.
Originality/relevance: Another important contribution of the research is the availability of an analysis framework, which has been statistically validated (observable variables and constructs). In this context, the Framework proposed in the research can be replicated in different regional, national, and international contexts.
PERBAIKAN METODE BUDIDAYA IN VITRO SAWIT (Elaeis guineensis Jacq.) MENGGUNAKAN TEMPORARY IMMERSION SYSTEM (TIS)
Authors: Ernayunita Ernayunita , Taryono
Published: April 2023

Temporary Immersion System (TIS) merupakan salah satu metode perbanyakan berbasis bioreaktor yang menggunakan sistem perendaman sesaat. Sistem perendaman yang hanya sesaat dan secara berkala memfasilitasi sel mendapatkan cukup oksigen, serta membatasi paparan dengan media kultur sehingga mampu menekan abnormalitas. Oleh karena itu, TIS potensial digunakan untuk perbanyakan kelapa sawit melalui budidaya in vitro yang secara umum masih terkendala adanya abnormalitas. Selain itu, perbaikan teknik budidaya in vitro kelapa sawit menggunakan TIS memungkinkan pergantian medium dilakukan secara otomatis sehingga mampu menekan kontaminasi. Penggunaan TIS juga mampu memberikan dampak positif khususnya dalam perbaikan fisiologis sel berupa peningkatan mutu dan regenerasi kalus, tinggi tanaman dan persentase pembentukan akar yang lebih baik dibandingkan dengan media padat maupun media cair lainnya. Planlet yang dihasilkan dari TIS memiliki laju respirasi yang rendah sehingga planlet tidak mudah mengalami dehidrasi dan mampu beradaptasi di lingkungan aklimatisasi. Selain itu, perbaikan teknik kultur in vitro menggunakan TIS dilaporkan mampu menekan abnormalitas planlet beberapa komoditas perkebunan salah satunya kelapa sawit.
Islam and the Foundation of the State in Indonesia: The Role of the Masyumi Party in the Constituent Assembly the Perspective of Fiqh al-Siyāsah
Authors: Yusuf Adan Hasanuddin , Iskandar Iskandar , Ibrahim Husaini , Helfianti Sutri , Rosmawati Rosmawati
Published: April 2023

At the commencement of Indonesian independence, the Masyumi Party was the sole prominent Islamic party. It attempted to include Islam as the foundation of the Indonesian state into its constitution. This study aims to investigate the effort of the Masyumi during their active participation and administration of the government throughout the Old Order period in the context of fiqh al-siyāsah. This research is a qualitative legal study employing the approach of fiqh al-siyāsah or Islamic politics. Meanwhile, data collection techniques were carried out through literature studies and in-depth interviews. The results of this study indicate that Masyumi's efforts in the Constituent Assembly, whose task is to draft the Indonesian State Constitution, were carried out very seriously and earnestly, causing the work of the Constituent Assembly members to drag on because there was no point of convergence between the Masyumi Islamic Party and the national parties. As a result of the absence of a meeting point, President Soekarno, with the support of the Indonesian Army, issued a decree on July 5, 1959, dissolving the Constituent Assembly and reverting to the 1945 Constitution. It turned out that the failure of Masyumi's hard work to make Islam the basis of the state was due to internal factors: communist, nationalist, and secularist ideology. In addition, it was also influenced by several external factors: the infiltration of the global superpowers and Islamophobia.  Despite the fact that Masyumi was deemed a failure, various contributions in the context of fiqh al-siysah in Indonesia, particularly resistance to communism, contributed color to an Islamic state administration system as well as adherence to the constitution and theistic democracy.
The Promise of Diversity: Distribution-based Hydrologic Model Evaluation and Diagnostics
Authors: Vrugt Jasper A.
Published: April 2023

This paper advocates the use of
simulation distributions for hydrologic model evaluation and model
diagnostics. Distribution evaluation is supported by
information-theoretic arguments and puts into modeling practice the
social justice narrative of diversity, equity and inclusion for
different simulations. We discuss past developments that led to the
current state-of-the-art of forecast verification in hydrology and bring
to the fore scoring rules for model evaluation and diagnostics. Strictly
proper scoring rules condense a distribution forecast to a single reward
value for the materialized outcome(s) and have a strong underpinning in
statistical, decision and information theory. We review scoring rules
for dichotomous and categorical events, quantiles (intervals) and
density forecasts, discuss the importance of scoring rule propriety and
address diagnostic aspects such as sharpness, reliability and entropy.
The usefulness and power of scoring rules is demonstrated on simple
benchmark problems and discharge distributions simulated with conceptual
watershed models using GLUE and Bayesian model averaging. We also link
scoring rules to model diagnostics and present strictly proper
divergence scores for flood frequency analysis and flow duration and
recession curves. Scoring rules offer a rigorous information-theoretic
underpinning to model evaluation and diagnostics and provide
statistically principled means for (Bayesian) model selection and the
analysis of hydrograph functionals, flood frequencies and extreme
events.
Domain of q-Cesàro matrix in Hahn sequence space hd and the space bv of the sequences of bounded variation
Authors: Yaying Taja , Kirişçi Murat , Hazarika Bipan , Tuğ Orhan
Published: April 2023

Let hd = n f = (fk) ? ? : P k dk| fk ? fk+1| < ? o ? c0, where d = (dk) is an unbounded and monotonic increasing sequence of positive reals. We study the matrix domains hd(Cq) = (hd)Cq and bv(Cq)=(bv)Cq, where Cq is the q-Ces?ro matrix, 0 < q < 1. Apart from the inclusion relations and Schauder basis, we compute ?-, ?- and ?-duals of the spaces hd(Cq) and bv(Cq). We state and prove theorems concerning characterization of matrix classes from the spaces hd(Cq) and bv(Cq) to any one of the space ??, c, c0 or ?1. Finally, we obtain certain identities concerning characterization of compact operators using Hausdorff measure of non-compactness in the space hd(Cq).
Management of the Bone Deformity Caused by Congenital Cyst of the Periorbital Area: Analysis of the Surgical Technique and a Short-term Outcome
Authors: Tymofieiev Oleksii , Fesenko Ievgen , Cherniak Olha , Zaritska Valentyna , Snisarevskyi Pavlo , Shelest Oksana
Published: April 2023

The congenital periorbital cysts like dermoids/epidermoids, in rare cases, can require not only its’ excision but also correction/camouflage of the caused bone deformity. This management can require virtual surgical planning, osteotomy, and placement of the custom-made patient implant. In this report, the ultrasonography (USG) was proved as a highly effective imaging for the presurgical verification of the mass’s structure and establishment of the clinical diagnosis. The multi-slice computed tomography (MSCT), even on a two-slice MSCT machine, provided high-quality three-dimensional reconstruction of the area of bone deformation caused by the cyst and allowed for accurate surgical planning. A 20-year-old male patient with a congenital periorbital epidermoid cyst that led to the deformation of the lateral orbital rim was treated using the soft tissue volume-increasing technique for the correction of bone deformation following cyst removal. Analysis of the terminological diversity related with dermoid/epidermoid cysts is presented. Early diagnostics and management of congenital periorbital cysts can decrease the visual, orbital, and esthetic complications, as well as the need to perform bone reconstructive surgeries or other corrective surgical procedures.
Pemberdayaan Masyarakat Melalui Program Yayasan Baitul Maal-Bank Rakyat Indonesia (YBM-BRI)
Authors: Prasetyo Jati Didit Gunawan
Published: April 2023

Desa Getas memiliki banyak potensi dalam bidang sumber daya alam dan objek wisata. Namun, dikarenakan keterbatasan akses terhadap informasi teknologi, komunikasi serta finansial potensi di desa Getas tidak dapat dimanfaatkan secara maksimal. Maka dari itu, harus dilakukan upaya pemberdayaan sosial melalui aktivitas penyebaran atau edukasi mengenai perencanaan dan pengelolaan potensi dari desa Getas. Upaya ini dapat diwujudkan dengan program Yayasan Baitul Maal-Bank Rakyat Indonesia (YBM-BRI). Program YBM-BRI fokus terhadap aspek di tiga kategori yaitu pendidikan, sosial, dan ekonomi. Dalam aspek sosial, program ini bertujuan untuk memberikan layanan berupa bantuan tanggap bencana dan aktivitas kemanusian, pemberian bantuan ini dapat meringankan beban ekonomi masyarakat desa Getas yang membutuhkan serta dapat menjadi cara penyaluran zakat. Di aspek Pendidikan tujuan yang berusaha dicapai adalah memfokuskan untuk memberikan layanan berupa pemberian edukasi, bantuan dana dan beasiswa Pendidikan. Pelaksanaan aspek ini dapat memberikan insentif bagi masyarakat desa Getas untuk melanjutkan pendidikan ke jenjang yang lebih tinggi serta memperbaiki sistem pendidikan di desa mereka. Dan yang terakhir, di dalam aspek ekonomi, program ini bertujuan untuk memberikan bantuan penyuluhan informasi mengenai pemanfaatan sumber daya alam dalam upaya peningkatan ekonomi, pemberian informasi pemanfaatan potensi desa seperti sumber daya alam dan objek pariwisata ini dapat memberikan nilai perekonomian bagi masyarakat desa Getas dalam bentuk pemasukan dari penjualan hasil tanam dan hasil olahannya serta dari pengelolaan objek wisata. Dengan beragam manfaat yang dapat diberikan dari pelaksanaan program pelayanan sosial YBM-BRI, program ini dapat membantu desa Getas untuk memanfaatkan sumber potensi perekonomian mereka serta memberikan edukasi dan bantuan kepada masyarakat desa Getas berupa informasi, edukasi dan finansial.
Post-Brexit exchange rate volatility and its impact on UK exports to eurozone countries: A bounds testing approach
Authors: Naimy Viviane , Khoury Rim , Montero José-María , Souk Jana
Published: April 2023

Research background: The Brexit referendum had a profound effect on the economic relations between the United Kingdom (UK) and continental Europe. Major economic and financial determinants were affected, including the impact of the GBP/EUR exchange rate volatility on the dynamics of UK exports to the Eurozone.
Purpose of the article: This paper seeks to assess the extent to which these dynamics have changed since Brexit and to estimate the magnitude of their impact.
Methods: To this end, the volatility behavior of the GBP/EUR exchange rate before and after Brexit is captured using EWMA, GARCH(p,q), and EGARCH(p,q) models for the period of January 1, 2010 to August 31, 2020. The post-Brexit change in the volatility structure of GBP/EUR exchange rates is then tested by including a dummy in the optimal volatility model. Finally, the Autoregressive Distributed Lag (ARDL) Bounds Testing approach is employed to analyze the relationships between exchange rate volatility and exports.
Findings & value added: GARCH(1,1) was selected as the winning model and used to examine the volatility structure of the post-Brexit exchange rate, which revealed no significant change. By incorporating a well-grounded proxy for exchange rate volatility into the demand function of exports, and controlling for the industrial production index, terms of trade, and real exchange rate, the analysis showed that exchange rate volatility had a negative impact on export volume to the Eurozone in both the long and short run. Additionally, the industrial production index had a positive effect on export volume in both the long and short run, while an appreciation in the value of the pound relative to the euro adversely affected the competitiveness of UK exports in the Eurozone market in the long run, with no impact in the short run. This paper serves as a benchmark for future studies, as it follows a three-step modeling approach and provides valuable insights into the potential economic and financial consequences a European Union (EU) member state may face should it choose to exit the EU.
Application of Progressive Web Apps (PWA) on PT SKA’s E-Commerce Website
Authors: Eunike Evangeline , Sanjaya Ridwan , Widiantoro Albertus Dwiyoga
Published: April 2023

Mobile app developers are often overwhelmed when they must create mobile applications, which must create applications for iOS and Android users. The problem is that each one has a different programming language, for iOS users it must be developed with Objective-C or Swift while for Android it is developed with Kotlin or Java programming language. This research was conducted with a tool that in the research process using observation. Observations were made by testing native applications with applications that were already using Progressive Web Apps (PWA) using the PageSpeed Insights tool. Progressive Web Apps (PWA) help optimize websites so that they look like native applications both on computers and on mobile. Application can be accessed offline, provide notifications, and there is no need to download application on the PlayStore or App Store, just through the website. This PWA exists to address these issues. PWA makes things faster and optimizes quality.
Pengaruh Pelatihan Kader terhadap Peningkatan Keterampilan Pengukuran Tinggi Badan dan Penilaian Status Stunting pada Balita di Desa Kadubale, Kecamatan Banjar, Kabupaten Pandeglang Tahun 2022
Authors: Nurul Azizan Fahmy , Sri Rahayu Leni , Nur Aini Rahmatika
Published: April 2023

Prevalensi stunting yang masih tinggi pada balita serta masih rendahnya keterampilan kader posyandu dalam mengukur tinggi badan dan menilai status stunting akan berdampak pada keakuratan hasil pengukuran oleh karena itu perlu dilakukan pelatihan kepada kader. Penelitian ini bertujuan untuk mengetahui pengaruh pelatihan kader terhadap peningkatan keterampilan pengukuran tinggi badan dan penilaian status stunting pada balita di Desa Kadubale Kecamatan Banjar Kabupaten Pandeglang. Penelitian ini menggunakan desain penelitian pre eksperimental dengan rancangan one group pretest postest. Pengambilan subjek dalam penelitian ini menggunakan metode total sampling. Penelitian ini dilakukan kepada 37 orang kader posyandu. Pengambilan data keterampilan menggunakan instrumen daftar tilik untuk mengetahui peningkatan skor keterampilan. Analisis data dilakukan secara univariat dan bivariat, analisis data bivariat menggunakan uji Wilcoxon. Hasil penelitian menunjukkan bahwa terjadi peningkatan skor rata-rata keterampilan kader antara sebelum dan setelah diberikan pelatihan dalam mengukur tinggi badan (5,62 menjadi 9,46) dan penilaian status stunting (0 menjadi 12) dengan nilai signifikansi (p<0,001). Dengan demikian pelatihan kader efektif dalam meningkatkan keterampilan kader posyandu.
Perilaku Makan Tipe Emotional, External dan Restrained Kaitannya dengan Indeks Massa Tubuh Mahasiswa
Authors: Nurdiani Reisi , Rahman Nadya Asy syifa , Madanijah Siti
Published: April 2023

Transisi siswa menjadi mahasiswa merupakan periode penting dalam menentukan pilihan perilaku makan yang berkontribusi terhadap kualitas hidup. Tujuan penelitian adalah menganalisis tipe-tipe perilaku makan serta kaitannya dengan status gizi mahasiswa. Desain penelitian adalah cross sectional study yang melibatkan 230 orang subjek. Data perilaku makan didapat berdasarkan pengisian Dutch Eating Behaviour Questionnaire (DEBQ), data berat badan dan tinggi badan diperoleh dengan pengukuran secara langsung. Hasil penelitian menunjukkan bahwa rata-rata skor perilaku makan subjek emotional eating, external eating dan restrained eating adalah 2,27±0,74;3,30±0,56 dan 2,41±0,75. Sebanyak 15,7% subjek berstatus gizi lebih dan obese serta 7,8 subjek berstatus gizi kurang. Perilaku makan external eating (p=0,008, r=-0,175) dan restrained eating (p=0,000, r=0,485) secara signifikan berhubungan dengan IMT. Skor restrained eating lebih tinggi pada subjek dengan status gizi lebih dan obese sedangkan skor external eating lebih tinggi pada subjek dengan status gizi normal dan kurang. Hasil penelitian dapat menjadi masukan untuk mengembangkan strategi preventif masalah gizi pada mahasiswa dengan pedekatan perilaku makan.
Lessons Learned: A Disruption in Care Leads to Increased Rates of Proximal Amputations
Authors:   Resident Physician, Department of Surgery, Zucker School of Medicine at Hoftsra/Northwell, Hempstead, NY, Yu Justin , Joshi Jai ,   Department of Surgery, Comprehensive Wound Healing & Hyperbaric Center, Northwell Health, Lake Success, NY, Wong Carmen ,   Resident Physician, Department of Podiatry, Long Island Jewish/North Shore, New Hyde Park, NY, Ahmed Nafis ,   Resident Physician, Department of Podiatry, Long Island Jewish/North Shore, New Hyde Park, NY, Rao Amit ,   Department of Surgery, Comprehensive Wound Healing & Hyperbaric Center, Northwell Health, Lake Success, NY, Li Timmy ,   Department of Emergency Medicine, Zucker School of Medicine at Hoftsra/Northwell, Hempstead, NY, Al Rubaiay Ammar ,   Department of Podiatry, North Shore University Hospital Specialty Clinic, Northwell Health, Manhasset, NY, Landis Gregg ,   Division of Vascular and Endovascular Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY, Oropallo Alisha ,   Department of Surgery, Comprehensive Wound Healing & Hyperbaric Center, Northwell Health, Lake Success, NY; Division of Vascular and Endovascular Surgery, Zucker School of Medicine at Hofstra/Northwell, Hempstead, NY
Published: April 2023

BACKGROUND: In March 2020, due to the COVID-19 pandemic, hospitalizations in New York state were restricted to emergency purposes. Non-COVID related cases involving lower extremity wounds were only admitted for acute infections and limb salvage. Patients with these conditions were placed at higher risk for eventual limb loss. PURPOSE: To understand the impact of COVID-19 on amputation rates. METHODS: A retrospective review of lower limb institution-wide amputations was conducted at Northwell Health from January 2020 to January 2021. The amputation rates during the COVID-19 shutdown period were compared to the pre-pandemic, post-shutdown, and reopening period. RESULTS: The pre-pandemic period had 179 amputations, of which 8.38% were proximal. 86 amputations were performed during shutdown, with a greater proportion being proximal (25.58%, p=0.0009). Following the shutdown period, amputations returned to baseline. The proportion of proximal amputations during post-shutdown was 18.5% and during reopening was 12.06%. Patients had 4.89 times higher odds of undergoing a proximal amputation during the shutdown period. CONCLUSIONS: The effect of COVID-19 on amputation rates demonstrates an increase in proximal amputation during the initial shutdown. This study suggests an indirect negative effect of COVID-19 hospital restrictions on surgeries during the initial shutdown period.
Does Emotional Intelligence Affect Mental Toughness in Physically Disabled Athletes?
Authors: YARAYAN Yunus Emre , İLHAN Ekrem Levent , ESENTÜRK Oğuz Kaan , ARI Çağrı , GÜLŞEN Doğukan Batur Alp
Published: April 2023

The aim of this research is to determine the determinative role of the emotional intelligence sub-dimensions (Assessing others emotions, evaluating their own emotions, regulating emotions, using social skills, use of emotion) in determining the levels of mental toughness of the athletes with disabilities. A total of 261 athletes from 165 disabled athletes (wheelchair basketball, amputee football, sitting volleyball, badminton), male (63.2%) (24.40±5.48 years old) and 96 female (36.0%) participated voluntarily. Within the scope of the research, information about socio-demographic variables was collected by the personal information form created by the researchers. To reach the purpose of the research; The Sport Mental Toughness Questionnaire made by Altıntaş and Bayar (2015) and the Emotional Intelligence Inventory in Sport adapted to Turkish by Adiloğulları and Görgülü (2015) were used. In the analysis of the data, firstly, when the skewness and kurtosis values for the normality assumptions were examined, it was determined that the distribution was normal. In this direction correlation analysis to determine the relationship between variables, stepwise regression analysis was used to determine the power of independent variables in predicting dependent variables. According to the findings obtained as a result of the research, it has been determined that the emotional intelligence levels of the athletes are important determinants of the mental toughness levels, and the analysis completed in three stages explains 56% of the variance.
Many-body Potential for Simulating the Self-Assembly of Polymer-Grafted Nanoparticles in a Polymer Matrix
Authors: Zhou Yilong , Bore Sigbjorn , Tao Andrea , Paesani Francesco , Arya Gaurav
Published: April 2023

Many-body interactions between polymer-grafted nanoparticles (NPs) play a key role in promoting their assembly into low-dimensional structures within polymer melts, even when the particles are spherical and isotropically grafted. However, capturing such interactions in simulations of NP assembly is very challenging because explicit modeling of the polymer grafts and melt chains is highly computationally expensive, even using coarse-grained models. Here, we develop a many- body potential for describing the effective interactions between spherical polymer-grafted NPs in a polymer matrix through a machine learning (ML) approach. The approach involves using permutationally invariant polynomials to fit two- and three-body interactions derived from potential of mean force (PMF) calculations. This potential developed here reduces the computational cost by several orders of magnitude, thereby allowing us to explore assembly behavior over large length and time scales. We show that the potential not only reproduces previously known assembled phases, such as 1D strings and 2D hexagonal sheets, which cannot be achieved using two-body potentials, but can also help discover interesting new phases, such as networks, clusters, and gels. We demonstrate how each of these assembly morphologies intrinsically arises from a competition between two- and three-body interactions. Our approach for deriving many- body effective potentials can be readily extended to other colloidal systems, enabling researchers to make accurate predictions of their behavior and dissect the role of individual interaction energy terms in the overall potential in the observed behavior.