bluuebunny/crossref_metadata_2025 huggingface dataset:
Dos limites constitucionais à admissibilidade de cláusula anticorrupção
Authors: Pimenta Oliveira José Roberto , Gomes Denis Dela Vedova
Published: July 2021

A repartição de competências na Constituição da República Brasileira concentrou na União a capacidade legislativa para disciplinar assuntos relacionados à licitação e ao contrato administrativo, com o objetivo de trazer uniformidade e segurança jurídica na definição de regras para as contratações, por meio de normas gerais nacionais. Iniciativas legislativas estaduais e municipais que exigem a implementação de programa de integridade dos licitantes, diante do vácuo normativo federal, a pretexto de aparentarem maior disposição à prevenção e ao combate à corrupção, violam os critérios de organização política do Estado Brasileiro, podendo gerar efeito diametralmente oposto à causa que a motiva. Ademais, deve-se avaliar se a exigência é proporcional frente aos princípios regentes à licitação e ao direito à livre iniciativa.
A legalidade de prazo de impugnação do edital previsto no Decreto nº 10.024, de 2019
Authors: Zockun Carolina Zancaner , Sarai Leandro
Published: July 2021

O presente artigo, a partir do método hipotético dedutivo, e com base na legislação, na doutrina e jurisprudência, procurará abordar a questão da suposta ilegalidade da alteração do prazo para impugnação do edital de licitação, que foi promovida pelo Decreto nº 10.024, de 20 de setembro de 2019. Para tanto, após demonstrar a presunção de validade que milita em favor do Decreto, mostrará que, além de haver sólidos fundamentos para sustentar essa validade, não existe prejuízo aos licitantes. Após exposta essa análise, o artigo aponta o motivo pelo qual reputa válido o Decreto.
Práticas de Contabilidade Gerencial no Terceiro Setor: o Desafio da Gestão Eficiente
Authors: Innocenti Renícia , Gasparetto Valdirene
Published: July 2021

O estudo objetiva verificar se a implementação de práticas de contabilidade gerencial apoia o alcance da eficiência em uma fundação privada educacional brasileira. Foi realizado estudo de caso com pesquisa de natureza descritiva, abordagem qualitativa e coleta de dados por meio de documentos e questionário. Os resultados mostraram que a implementação das práticas de contabilidade gerencial foi direcionada para o atendimento das demandas da Fundação e por adequação às expectativas da sociedade. Práticas tradicionais de contabilidade gerencial são efetivamente conhecidas e utilizadas e têm um papel decisivo no processo de gestão da Fundação, contribuindo para o alcance da eficiência organizacional.
CIVILIZATION, ECONOMIC SYSTEM OF SOCIETY, INSTITUTIONAL MATRICES, FOREIGN LANGUAGE AND NATIONAL SECURITY: HIDDEN INTERRELATIONSHIPS
Authors: Solodovnikov S.
Published: July 2021

The article through the interdisciplinary approach reveals the interdependence of civilization, economic system of society, institutional matrices, foreign language and national security. The nature, functionality and vital mechanisms of these phenomena are shown.
Four factors are in force pandemic joints to initiate an illicit dual use technologies transfer from Ukraine
Authors: Kartuzov Iegor
Published: July 2021

An objective of this effort is a quick recap to assess the underpin barriers of transfer of technologies appeared in Ukraine after acquiring the Independence and those developed of today and to highlight and evaluate an impact of political, historical, mental and other factors affecting the science and as a consequence leakage of technologies abroad. Of importance is also a question if a current COVID-19 pandemic will join these factors if it initiates an illicit transfer of dual use (DU) technologies from Ukraine as it was in 1990s and how it affects an efficient and proper functioning and optimization of transfer of technologies process, and that is quite a challenge nowadays.

Investigated problem. The process of technology transfer and specifically that one of DU as a whole is neither simple nor systematic and far from being that perfect, especially when it deals with dual-use technologies and at present reduced to a short relationship between supplier/recipient only. The experience and practice show that it is a rather complicated, multi-leveled and multi-players process which is impacted and follows several factors and conditions that determine its success and/or failure at the end.

The main scientific results. The development of dual use technologies continues in a quagmire of conflicting interests and technology transfer export control rationales. There are historical, mental and political-military considerations where a state’s decision to develop weapon systems or related applications can be assessed not only as a function of perceived levels of threat to its security, but also as a need to respond and/or step forward to potential technological innovations; and second, the fundamental conceptual differences in appreciation among countries of the right to possess different advanced weapons systems for defensive or offensive purposes.

The result of this endeavor makes a solid ground floor for further debates in terms of political science, export control regulations and factors affecting transfer of sensitive technologies.
Technologization of human of the postmodern age as a challenge to the natural reality of the earth
Authors: Pylypenko Svitlana
Published: July 2021

Object of research: technology as a component of human social life in the context of the postmodern era.

Investigated problem: determination of the features of the influence of technological processes on a person of the postmodern era, as a result of which the natural is replaced by an artificial one and the images of both man and the Earth change.

Main scientific results: the study of the contradictions of the process of technologization in the postmodern era made it possible to determine the transformation processes taking place in the life of a person and society. This defines social reality, represented by various markers, among which technology is gaining in importance. The latter act as a composite, which provides new opportunities for determining the relationship between the elements of the "world - man - culture" system. It is not only about the emergence of new human figures, among which the technological man (Homo Technologicus) occupies a prominent place, but also the emergence of a new image of the Earth, where the natural is replaced by the technological.

The scope of practical use of the research results: the research results can be used in teaching normative courses "Philosophical Anthropology", "Ethics", "Sociology" for students and undergraduates, graduate students of humanitarian and natural faculties.

Innovative technological product: the plurality of existing technologies (economic, medical, educational, humanitarian, etc.) destroys the new European concept of culture and man, which were provided within the framework of the monoparadigm. The anthropological dimension of technology testifies that the latter are beginning to act as a condition for human expansion. This situation has a significant impact on the existentials of human existence.

The scope of using the innovative technological product: the intensive technologization of the last decades not only provokes environmental risks and changes the state of the Earth, the natural reality of the Earth is replaced by an artificial one, which allows to conclude that the Earth is formed by a technological one.
Striving for Sustainable Architecture in the 21st Century – Main Issues in the Development of Innovative Office Space Concepts
Authors: MILOŠEVIĆ Predrag , MILOŠEVIĆ Vladimir , MILOŠEVIĆ Grigor
Published: July 2021

The knowledge on office building in the past and present, how the workspace evolved to incorporate contemporary technological breakthroughs, was in this paper combined with goals of sustainable building in a “smart” office building design in Belgrade, Serbia, taking local factors into consideration to create a comfortable space for the employees in a dense urban matrix with a minimal environmental footprint, and considering the workflow of contemporary office spaces, it’s multidirectional input and increasingly horizontal work hierarchy. Issues of proper inputs for building today in the 21st century are thoroughly considered in this paper and respective building’s design features as shown here: how to deal with location, position and orientation of the building, organization of both formal and informal areas, natural ventilation, green glazed surfaces, solar energy, wind turbines, rainwater utilization measures, surrounding vegetation, lighting and appliances, and piezoelectric paving.
The Torsional and Shear Behavior of Steel Fiber Reinforced RC Members
Authors: AYDIN Abdulkadir Cüneyt , KILIÇ Mahmut , MAALI Mahyar , BAYRAK Barış , TUNÇ Erkan
Published: July 2021

Beams and columns are one of the important structural elements of buildings to take up transverse loads such as axial load, bending moment, shear, and torsion. Present work is an experimental investigation on the shear, torsion, and axial load behavior of the structural members like columns and/or beams. The reinforced concrete members with 0, 30, and 60 kg/m3 of steel fibers were tested for torsion, shear and axial loading for this study. The twist angle, the load-deflection behavior, the ultimate shear strength, the torsional moment, and the critical moments were obtained for the loading type and steel fiber ratios. The results show that the increasing steel fiber ratio, increased the torsional moment capacity and decreased the shear strength capacity. On the other hand, increasing the steel fiber content increased the both axial load and moment capacity of RC columns. The shear strength and the torsional moment capacities are defined by the provision of current codes of practice such as ACI318-19, Eurocode-2, British, Australian and Turkish Standards.
BEYOND NATIONHOOD: HAUL MUSIC FROM A POSTCOLONIAL PERSPECTIVE IN WESTERN SAHARA AND MAURITANIA
Authors: Amoros Luis Gimenez
Published: July 2021

This article examines the mobility of a precolonial musical style known as Haul music in two African countries, Western Sahara and Mauritania. Haul music is based on a modal system in which music and poetry are intrinsically related. This article traces the historical and musicological aspects of the Haul modal system in Western Sahara and Mauritania by offering an insight into how the postcolonial period has determined two narratives of Haul: a historical nationalism by way of revitalising the precolonial past in Mauritania; and political nationalism when reconsidering the ongoing process of decolonisation in Western Sahara and the exile of its people to the refugee camps of the Hamada desert since 1975. Further, this article shows how the mobility of the Haul modal system provides a reconsideration of a precolonial past in existing music cultures in North Africa.
ARRULLOS, CHIGUALOS AND ALABAOS: TRADITIONAL AFRO-ESMERALDENIAN MUSIC IN ECUADOR
Authors: Palacios Fernando
Published: July 2021

In this article I examine traditional Afro-Esmeraldenian music as manifested in religious and spiritual contexts. I discuss the repertoire’s formal musical aspects and its associated factors. I argue that the traditional music of the Afro-Esmeraldenian community is evidence of a performance culture that has taken on the characteristics of first nation Americans and Spanish colonisers, while retaining a distinct African identity mostly in the musical instruments such as the marimba, rattles and drums, in the polyrhythms and in the distinctive responsorial singing. )e religious sphere is a fundamental and representative space for understanding the cosmovision and symbolism of the Afro-Esmeraldenians, a population located on Ecuador’s northern Pacific coast, originally settled during forced migration of Africans to America between the sixteenth and nineteenth centuries. Here, traditional musical practices have survived through generations and reflects the importance of the spiritual world for this cultural group. In addition, it is likely that the religious sphere has contributed significantly to the validity and durability of the Afro-Esmeraldenian musical repertoire and the instruments making up the traditional ensemble.
BRASS BAND MUSIC IN GHANA: THE INDIGENISATION OF EUROPEAN MILITARY MUSIC
Authors: Dordzro John-Doe
Published: July 2021

Local brass bands have become an indispensable factor in weddings, processions, rituals of birth or death, at Christmas and New Year festivities in many parts of the globe. Remains of European brass bands are widely distributed throughout Africa, India, Indonesia, Latin America, and the Caribbean. )ese bands are of both military and missionary origin. They are an important component of the nineteenth and early twentieth-century colonial expressive culture. Despite their uniqueness and widespread presence across the world, brass bands have received limited attention in Ghana. )is paper aims to address this lack by offering a comprehensive account of the contemporary situation of brass band music in Ghana. I trace the history of this musical world and explore the diverse ways military and missionary activities have shaped amateur brass band musical activities in Ghana. I discuss the distribution and band formations across Ghana, viewing it in five sections that detail different types of brass bands; church, town, service, school and “sharbo” bands. I continue by looking at the beginning, development, workings and indigenisation of European military music in local popular culture and provide an account of brass band music as observed in Ghana today. I argue that indigenisation is not a straightforward process of adaptation, rather, indigenisation is a process of ongoing aesthetic tensions and differences resulting in new musical forms and new forms of socialisation organised around musical performance.
Comparing data Reported Using the National Health Management Information System and data Declared Validated on the PBF Declaration Forms in Funding Health Districts in Nasarawa State
Authors: Ezekiel Prince Olueseh
Published: July 2021

The National Health Management Information System (NHMIS) Was Designed To Provide Timely And Reliable Health Service Delivery Information. The Efficiency And Effectiveness Of Health Service Delivery Is Assessed By The Availability Of Quality, Complete And Timely Data. The NHMIS Policy Review Was Initiated By A Consortium Of Relevant Stake Holders Led By The Department Of Planning, Research And Statistics (DPRS) Of The Federal Ministry Of Health (FMOH) And The National Primary Health Care Development Agency (NPHCDA). The Emphasis Of The NHMIS Is To Strengthen The Health Information System-HIS In The Country And Promote The Use Of Quality Information For Evidence-Based Decision-Making At The Community, LGA, And National Levels. In Spite Of Substantial Investments, The Health Sector In Nigeria Has Made Slow Progress In Improving Its Health Indices. Thus The Nigeria State Health Investment Project(NSHIP), Through Support From WHO, Introduced The Performance-Based Financing –PBF Currently Rolled Out In Three States- Adamawa, Nasarawa, And The Ondo States To Deliver A Result-Based Approach To Improve Quantity And Quality Of Health Services Especially In The Area Of Maternal Health. Health Centers Receive Funds Directly Based On The Number Of Essential Services They Delivered And The Improved Quality Of Care. This Encouraged Health Centers To Focus On Delivering Results, And The New Funds Enabled Them To Improve Their Services. This Study Compared Data Reported Using The NHMIS And Declared Validated On The PBF Declaration Forms In Funding Health Facilities In Nasarawa State For Quarter 1 (Jan.- Mar.)2018 And Quarter 2 (Apr. – June) 2018.
The ten kinds of conditionals and Chrysippus’ criterion
Authors:   Institute of Humanistic Studies “Juan Ignacio Molina”, University of Talca, Talca Campus (Chile)., Astorga Miguel López
Published: July 2021

The theory of mental models proposed ten possible interpretations for the conditional. In particular, Johnson-Laird and Byrne provided those interpretations in 2002. On the other hand, in ancient times, Chrysippus of Soli claimed that conditionals have to fulfill a requirement: the negation of their consequents must be inconsistent with their antecedents. This paper considers the ten interpretations of the conditional the theory of mental models indicates as ten different kinds of conditionals. Thus, it analyzes those ten types from Chrysippus’ requirement. The results show that the ten kinds of conditionals that can be derived from the theses of the theory of mental models follow the criterion given by Chrysippus. Accordingly, it can be thought that the criterion refers to an essential characteristic of the conditional.
Domestic water improvement behaviour: the probability determinants and policy implications
Authors: Amoah Anthony , Asiama Rexford Kweku , Korle Kofi , Kwablah Edmund
Published: July 2021

Although water is important for human livelihoods, access and use of improved domestic water for households in most developing countries is still a major problem. Households adopt several domestic water improvement mechanisms to improve the quality of their water before consumption. However, the drivers of the probability to engage in this behaviour have not been adequately explored in developing countries. Therefore, this study investigates the factors that determine the probability of choosing to improve domestic water quality before consumption, with data from a household survey implemented in Ghana. Using the Logit econometric model with its associated margins, this study shows evidence that environmental knowledge, age, gender and wealth are key drivers of the probability of engaging in a water improvement behaviour. Based on the identified drivers, practical lessons are discussed to inform policy decisions on the quality of water supply.
Vanillic Acid and Non-Alcoholic Fatty Liver Disease: A Focus on AMPK in Adipose and Liver Tissues
Authors: Shekari Sepideh , Khonsha Fatemeh , Rahmati-Yamchi Mohammad , Nejabati Hamid R. , Mota Ali
Published: July 2021

Non-alcoholic fatty liver disease (NAFLD), a growing health issue around the world, is defined as the presence of steatosis in the liver without any other detectable byproducts such as alcohol consumption, which includes a wide spectrum of pathologies, such as steatohepatitis, cirrhosis, and hepatocellular carcinoma. A growing body of evidence indicates that the reduction in the 5' adenosine monophosphate-activated protein kinase (AMPK) activity, which could be activated by the consumption of the drugs, hormones, cytokines, and dietary restriction, is related to some metabolic disorders such as obesity, diabetes, PCOS, and NAFLD. Vanillic acid (VA), as an anti-inflammatory, anti-oxidative, anti-angiogenic and anti-metastatic factor, has protective effects on the liver as in two animal models of liver damage, it reduces serum levels of transaminases, inflammatory cytokines, and the accumulation of collagen in the liver and also prevents liver fibrosis. Besides, it decreases body and adipose tissue weight in a mice model of obesity and, similar to the liver tissue, diminishes adipogenesis through the activation of AMPK. It has been reported that VA can target almost all of the metabolic abnormalities of NAFLD, such as hepatic steatosis, inflammation, and hepatic injury, at least partially through the activation of AMPK. Therefore, in this review, we will discuss the possible and hypothetical roles of VA in NAFLD, with a special focus on AMPK.
Theranostic Applications of Nanomaterials in the Field of Cardiovascular Diseases
Authors: Sahoo Rakesh K. , Singh Himani , Thakur Kamlesh , Gupta Umesh , Goyal Amit K .
Published: July 2021

:

A large percentage of people are being exposed to mortality due to cardiovascular diseases. Convention
approaches have not provided satisfactory outcomes in the management of these diseases. To overcome the
limitations of conventional approaches, nanomaterials like nanoparticles, nanotubes, micelles, lipid-based nanocarriers,
dendrimers, and carbon-based nanoformulations represent the new aspect of diagnosis and treatment of
cardiovascular diseases. The unique inherent properties of the nanomaterials are the major reasons for their
rapidly growing demand in the field of medicine. Profound knowledge in the field of nanotechnology and
biomedicine is needed for the notable translation of nanomaterials into theranostic cardiovascular applications.
In this review, the authors have summarized different nanomaterials which are being extensively used to diagnose
and treat the diseases, such as coronary heart disease, myocardial infarction, atherosclerosis, stroke and
thrombosis.
The Absence of Myelin Basic Protein Reduces Non-Amyloidogenic Processing of Amyloid Precursor Protein
Authors: Seiwa Chika , Sugiyama Ichiro , Sugawa Makoto , Murase Hiroaki , Kudoh Chiaki , Asou Hiroaki
Published: July 2021

Background:

The accumulation of amyloid β-protein (Aβ) in the brain is a pathological
feature of Alzheimer’s disease (AD). Aβ peptides originate from amyloid precursor protein (APP).
APP can be proteolytically cleaved through amyloidogenic or non-amyloidogenic pathways. The molecular
effects on APP metabolism/processing may be influenced by myelin and the breakdown of
myelin basic protein (MBP) in AD patients and mouse models of AD pathology.

Methods:

We directly tested whether MBP can alter influence APP processing in MBP-/- mice, known
as Shiverer (shi/shi) mice, in which no functional MBP is produced due to gene breakage from the
middle of MBP exon ll.

Results:

A significant reduction of the cerebral sAPPα level in Shiverer (shi/shi) mice was found, although
the levels of both total APP and sAPPβ remain unchanged. The reduction of sAPPα was considered
to be due to the changes in the expression levels of a disintegrin and metalloproteinase-9
(ADAM9) catalysis and non-amyloid genic processing of APP in the absence of MBP because it binds
to ADAM9. MBP -/- mice exhibited increased Aβ oligomer production.

Conclusion:

These findings suggest that in the absence of MBP, there is a marked reduction of nonamyloidogenic
APP processing to sAPPα, and targeting myelin of oligodendrocytes may be a novel
therapy for the prevention and treatment of AD.
Structural Modification of Sylibin to Derivatives of Sylibin/Hydnocarpin D/Silandrin, and Evaluation of their Cytotoxicity against Cancer Cells
Authors: Maihesuti Liwaliding , Gao Hongwei , Wang Qi , Cao Jianguo , Aisa Haji Akber , Huang Guozheng
Published: July 2021

Background:

Flavonolignans like silybin, hydnocarpin, and siliandrin are a group of natural
compounds combining the structural moieties of flavonoid and phenylpropanoid (lignan). Hydnocarpin
and silandrin have been less explored because of their trace occurrence in nature.

Objective:

The present study aimed at chemical conversion of silybin to hydnocarpin and siliandrin.
Another objective was to synthesize a series of amide derivatives and biologically evaluate
them with regard to their anti-cancer effects.

Methods:

In order to selectively convert silybin to 23-iodo silybin, 23-iodo hydnocarpin D and 23-
iodo isosilandrin, the ratio of Ph3P, imidazole and molecular iodine was meticulously adjusted. These
three iodide compounds were converted into amide compounds by chemical transformation.
MTT method was applied to evaluate their anti-cancer potency. The binding affinity to related proteins
was calculated by molecular docking.

Results:

A total of 45 new amido-derivatives were synthesized and structurally characterized by
NMR and HRMS. Some of them showed moderate to good antiproliferative potency against cancer
cells. The activity of compound 10j was further testified by colony formation assay and molecular
docking.

Conclusion:

The synthesis of 23-iodo silybin, 23-iodo hydnocarpin D and 23-iodo isosilandrin
from silybin was successfully accomplished by one simple iodination reaction. Some of the amide
derivatives of sylibin/hydnocarpin D /silandrin exhibited a remarkable inhibitory effect of proliferation
on cancer cells compared to silybin. These results would pave the way for further investigation
on the derivatives of flavonolignans for the treatment of cancer.
Nanotechnology, A Tool for Diagnostics and Treatment of Cancer
Authors: Nasir Abdul , Khan Amir , Li Jiayi , Naeem Muhammad , Khalil Atif Ali Khan , Khan Khalid , Qasim Muhammad
Published: July 2021

Nanotechnology has shown promising advancements in the field of drug development
and its delivery. In particular, the applications of nanoparticles for treatment and diagnostics of cancer
reached such a precision that it can detect a single cancer cell and target it to deliver a payload
for the treatment of that cancerous cell. Conventional cancer therapy methods have side effects,
and diagnostics techniques are time-consuming and expensive. Nanoparticles (NPs) such as polymeric
nanoparticles (nanogels, nanofibers, liposomes), metallic nanoparticles such as gold NP
(GNPs), sliver NP (AgNP), calcium nanoparticles (CaNPs), carbon nanotubes (CNTs), graphene,
and quantum dots (QDs) have revolutionized cancer diagnostics and treatments due to their high
surface charge, size, and morphology. Functionalization of these nanoparticles with different biological
molecules, such as antibodies, helps them to target delivery and early detection of cancer
cells through their plasmon resonance properties. While some of the magnetic properties of nanoparticles
such as iron (Fe), copper (Cu), and carbon NT were also evaluated for detection and treatments
of cancer cells. An advanced type of nanoparticles, such as nanobubbles and oxygen-releasing
polymers, are helping to address the hypoxia conditions in the cancer microenvironment, while
others are employed in photodynamic therapy (PDT) and photothermal therapy (PTT) due to their
intrinsic theranostic properties. The green synthesis of nanoparticles has further increased biocompatibility
and broadened their applications. In this review paper, we discussed the advancement in
nanotechnology and its applications for cancer treatment and diagnostics and highlighted challenges
for translation of these advanced nano-based techniques for clinical applications and their
green synthesis.
Captagon Use in a Patient with Iatrogenic Opioid Use Disorder
Authors: Hamdan Mohammed , El Hayek Samer , Bizri Maya
Published: July 2021

Background:

Captagon or Fenethylline is a synthetic theophylline derivative of amphetamine
that is widely available for recreational use in the Middle East. It has pain-reducing properties
and is known to induce restlessness, irritability, and psychotic symptoms.

Case presentation:

A middle-aged man with iatrogenic opioid use disorder was admitted for acute
cholecystitis. A week following cholecystectomy, the patient used Captagon while hospitalized to
manage opioid withdrawal pain. He experienced waxing and waning episodes of irritability, aggressiveness,
disorganized behaviors, delusions, and hallucinations, all concurrent with his Captagon intake.
These episodes were managed similarly to intoxication with other stimulant types.

Conclusion:

Careful patient counseling and close follow-up are essential when opioids are prescribed.
Captagon’s pain-reducing properties make it an attractive and dangerous option for Middle Eastern
patients suffering from opioid withdrawal. Captagon intoxication is currently managed similarly to
other stimulant types, but more studies are needed to develop management guidelines specific to this
substance.
Hoe een inheems perspectief de archeologische interpretatie kan verbreden
Authors: Desjardins Sean P.A.
Published: July 2021

How Indigenous-focused research can inform broader archaeological practice. In Europe, archaeologists have traditionally engaged less with the concept of Indigenous archaeology—and the various cultural-anthropological tenets underpinning it—than with the related, but distinct, concepts of ethnicity, nationalism and even autochthony, which are ostensibly more congruent with the various forms of social organization observed across the continent from pre-Neolithic times to the present. In this article, we argue that due to their recognition and embracing of unique systems of knowledge production (ontologies), contemporary Indigenous understandings of the past can inform the archaeologies of regions currently without Indigenous populations. We draw upon our experiences carrying out fieldwork amongst Indigenous peoples and within their traditional territories.
Het museum op de snijtafel: de archeologietentoonstelling onderzocht
Authors: Steffens Bastiaan
Published: July 2021

The Anatomy of the Museum: researching the archaeological exhibition. Archaeology exhibitions tend to follow a formulaic layout. They are mostly chronologically ordered and describe long-lasting historical processes. This article aims to dissect the archaeology museum in order to study the techniques used to create these narratives separately from each other. It is argued that the architecture of the old, monumental museum buildings was designed with specific purposes in mind that coincided with how archaeology was conceived in the 19th and early 20th centuries. Moreover, the way information is employed throughout exhibitions favours long-term histories over short-term object biographies. The end result is that archaeology exhibitions are often descriptive in nature rather than explanatory. Here it is argued that this is not in line with how academic archaeology is currently practiced. And that we need to adopt a perspective that approaches history as an active process of becoming, so that links between past and present can be clearly presented in a museum context. Such exhibitions have the ability to explain not only the past, but also our present situation, and perhaps even to act as a call to action to change this situation
Beeldvorming over Nederlandse kastelen vanuit de lucht
Authors: Spiekhout Diana
Published: July 2021

Aerial imaging of Dutch castles. Due to the increase in the quality and availability of LiDAR images and aerial photography, it is possible to investigate archaeological traces of Dutch medieval castles in detail. These aerial images show that most castle sites are much larger than previously thought. An interdisciplinary approach can help researchers to understand these sites, as the casus for castles with a system of multiple moats and embankments in the Oversticht shows. These were seen by the bishop and his allies – the cities of Zwolle, Deventer and Kampen – as military-functional architecture. Such observations change the conceptualization of castles in the Low Countries. Results like this example can be presented to a larger audience by working more closely with the entertainment industry.
Parasitismo de Gronotoma melanagromyzae Baerdsley (Hymenoptera: Figitidae: Eucoilinae), en el arrocillo del tomate de cáscara, Melanagromyza tomaterae Steyskal (Diptera: Agromyzidae)
Authors: Palacios Torres Rogelio Enriquez , Bautista Martínez Néstor
Published: July 2021

Melanagromyza tomaterae Steyskal is registered as a new host for Gronotoma melanagromyzae Beardsley, collected in the Valley of Mexico, Chapingo, Mexico.
Information and Scientific Impact of Advanced Therapies in the Age of Mass Media: Altmetrics-Based Analysis of Tissue Engineering
Authors: Santisteban-Espejo Antonio , Martin-Piedra Miguel Angel , Campos Antonio , Moran-Sanchez Julia , Cobo Manuel J , Pacheco-Serrano Ana I , Moral-Munoz Jose A
Published: July 2021

Background

Tissue engineering (TE) constitutes a multidisciplinary field aiming to construct artificial tissues to regenerate end-stage organs. Its development has taken place since the last decade of the 20th century, entailing a clinical revolution. TE research groups have worked and shared relevant information in the mass media era. Thus, it would be interesting to study the online dimension of TE research and to compare it with traditional measures of scientific impact.

Objective

The objective of this study was to evaluate the online dimension of TE documents from 2012 to 2018 using metadata obtained from the Web of Science (WoS) and Altmetric and to develop a prediction equation for the impact of TE documents from altmetric scores.

Methods

We analyzed 10,112 TE documents through descriptive and statistical methods. First, the TE temporal evolution was exposed for WoS and 15 online platforms (news, blogs, policy, Twitter, patents, peer review, Weibo, Facebook, Wikipedia, Google, Reddit, F1000, Q&A, video, and Mendeley Readers). The 10 most cited TE original articles were ranked according to the normalized WoS citations and the normalized Altmetric Attention Score. Second, to better comprehend the TE online framework, correlation and factor analyses were performed based on the suitable results previously obtained for the Bartlett sphericity and Kaiser–Meyer–Olkin tests. Finally, the linear regression model was applied to elucidate the relation between academics and online media and to construct a prediction equation for TE from altmetrics data.

Results

TE dynamic shows an upward trend in WoS citations, Twitter, Mendeley Readers, and Altmetric Scores. However, WoS and Altmetric rankings for the most cited documents clearly differ. When compared, the best correlation results were obtained for Mendeley Readers and WoS (ρ=0.71). In addition, the factor analysis identified 6 factors that could explain the previously observed differences between academic institutions and the online platforms evaluated. At this point, the mathematical model constructed is able to predict and explain more than 40% of TE WoS citations from Altmetric scores.

Conclusions

Scientific information related to the construction of bioartificial tissues increasingly reaches society through different online media. Because the focus of TE research importantly differs when the academic institutions and online platforms are compared, basic and clinical research groups, academic institutions, and health politicians should make a coordinated effort toward the design and implementation of adequate strategies for information diffusion and population health education.
A Deep Neural Network for Estimating Low-Density Lipoprotein Cholesterol From Electronic Health Records: Real-Time Routine Clinical Application
Authors: Hwang Sangwon , Gwon Chanwoo , Seo Dong Min , Cho Jooyoung , Kim Jang-Young , Uh Young
Published: July 2021

Background

Previously, we constructed a deep neural network (DNN) model to estimate low-density lipoprotein cholesterol (LDL-C).

Objective

To routinely provide estimated LDL-C levels, we applied the aforementioned DNN model to an electronic health record (EHR) system in real time (deep LDL-EHR).

Methods

The Korea National Health and Nutrition Examination Survey and the Wonju Severance Christian Hospital (WSCH) datasets were used as training and testing datasets, respectively. We measured our proposed model’s performance by using 5 indices, including bias, root mean-square error, P10-P30, concordance, and correlation coefficient. For transfer learning (TL), we pretrained the DNN model using a training dataset and fine-tuned it using 30% of the testing dataset.

Results

Based on 5 accuracy criteria, deep LDL-EHR generated inaccurate results compared with other methods for LDL-C estimation. By comparing the training and testing datasets, we found an overfitting problem. We then revised the DNN model using the TL algorithms and randomly selected subdata from the WSCH dataset. Therefore, the revised model (DNN+TL) exhibited the best performance among all methods.

Conclusions

Our DNN+TL is expected to be suitable for routine real-time clinical application for LDL-C estimation in a clinical laboratory.
Global Public Interests and Dynamic Trends in Osteoporosis From 2004 to 2019: Infodemiology Study (Preprint)
Authors: Wang Peng , Xu Qing , Cao Rong-Rong , Deng Fei-Yan , Lei Shu-Feng
Published: July 2021

BACKGROUND

With the prolonging of human life expectancy and subsequent population aging, osteoporosis (OP) has become an important public health issue.

OBJECTIVE

This study aimed to understand the global public search interests and dynamic trends in “osteoporosis” using the data derived from Google Trends.

METHODS

An online search was performed using the term “osteoporosis” in Google Trends from January 1, 2004, to December 31, 2019, under the category “Health.” Cosinor analysis was used to test the seasonality of relative search volume (RSV) for “osteoporosis.” An analysis was conducted to investigate the public search topic rising in RSV for “osteoporosis.”

RESULTS

There was a descending trend of global RSV for “osteoporosis” from January 2004 to December 2014, and a slowly increasing trend from January 2015 to December 2019. Cosinor analysis showed significant seasonal variations in global RSV for “osteoporosis” (P=.01), with a peak in March and a trough in September. In addition, similar decreasing trends of RSV for “osteoporosis” were found in Australia, New Zealand, Ireland, and Canada from January 2004 to December 2019. Cosinor test revealed significant seasonal variations in RSV for “osteoporosis” in Australia, New Zealand, Canada, Ireland, UK, and USA (all P<.001). Furthermore, public search rising topics related to “osteoporosis” included denosumab, fracture risk assessment tool, bone density, osteopenia, osteoarthritis, and risk factor.

CONCLUSIONS

Our study provided evidence about the public search interest and dynamic trends in OP using web-based data, which would be helpful for public health and policy making.
The Ethical Digital Surgeon (Preprint)
Authors: Lam Kyle , Purkayastha Sanjay , Kinross James M
Published: July 2021

UNSTRUCTURED

This viewpoint explores the ethical and regulatory consequences of the digital transformation of the operating room. Surgical robotics is undergoing significant change and future advances will center around the capture and use of data. The consequences of creating this surgical data pipeline must be understood and digital surgical systems must prioritize the safeguarding of patient data. Moreover, data protection laws and frameworks must adapt to the changing nature of surgical data. Finally, digital surgeons must understand changing data legislation and best practice on data governance to act as guardians not only for their own but also for their patients’ data.
A Casual Video Game With Psychological Well-being Concepts for Young Adolescents: Protocol for an Acceptability and Feasibility Study (Preprint)
Authors: Pine Russell , Mbinta James , Te Morenga Lisa , Fleming Theresa
Published: July 2021

BACKGROUND

Many face-to-face and digital therapeutic supports are designed for adolescents experiencing high levels of psychological distress. However, promoting psychological well-being among adolescents is often neglected despite significant short-term and long-term benefits.

OBJECTIVE

This research has 3 main objectives: (1) to assess the acceptability of Match Emoji, a casual video game with psychological well-being concepts among 13-15-year-old students in a New Zealand secondary school; (2) to identify the feasibility of the research process; and (3) to explore the preliminary well-being and therapeutic potential of Match Emoji.

METHODS

Approximately 40 participants aged 13-15 years from a local secondary college in Wellington, New Zealand, will be invited to download and play Match Emoji 3-4 times a week for 5-15 minutes over a 2-week period. Participants will complete 4 assessments at baseline, postintervention, and 3 weeks later to assess psychological well-being and therapeutic changes. Statistical analysis will be used to synthesize data from interviews and triangulated with assessment changes and game analytics. This synthesis will help to assess the acceptability and feasibility of the Match Emoji.

RESULTS

The key outputs from the project will include the acceptability, feasibility, and therapeutic potential of Match Emoji. It is anticipated that participants will have finished playing the recommended game play regimen by August 2021 with analysis of results completed by October 2021.

CONCLUSIONS

Data from the study are expected to inform future research on Match Emoji including a randomized controlled trial and further adjustments to the design and development of the game.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/31588
Prescribing Smartphone Apps for Physical Activity Promotion in Primary Care: Modeling Study of Health Gain and Cost Savings (Preprint)
Authors: Grout Leah , Telfer Kendra , Wilson Nick , Cleghorn Christine , Mizdrak Anja
Published: July 2021

BACKGROUND

Inadequate physical activity is a substantial cause of health loss worldwide, and this loss is attributable to diseases such as coronary heart disease, diabetes, stroke, and certain forms of cancer.

OBJECTIVE

This study aims to assess the potential impact of the prescription of smartphone apps in primary care settings on physical activity levels, health gains (in quality-adjusted life years [QALYs]), and health system costs in New Zealand (NZ).

METHODS

A proportional multistate lifetable model was used to estimate the change in physical activity levels and predict the resultant health gains in QALYs and health system costs over the remaining life span of the NZ population alive in 2011 at a 3% discount rate.

RESULTS

The modeled intervention resulted in an estimated 430 QALYs gained (95% uncertainty interval 320-550), with net cost savings of 2011 NZ $2.2 million (2011 US $1.5 million) over the remaining life span of the 2011 NZ population. On a per capita basis, QALY gains were generally larger in women than in men and larger in Māori than in non-Māori. The health impact and cost-effectiveness of the intervention were highly sensitive to assumptions on intervention uptake and decay. For example, the scenario analysis with the largest benefits, which assumed a 5-year maintenance of additional physical activity levels, delivered 1750 QALYs and 2011 NZ $22.5 million (2011 US $15.1 million) in cost savings.

CONCLUSIONS

The prescription of smartphone apps for promoting physical activity in primary care settings is likely to generate modest health gains and cost savings at the population level in this high-income country. Such gains may increase with ongoing improvements in app design and increased health worker promotion of the apps to patients.

CLINICALTRIAL
Machine learning and Grad-Cam based vascular aging assessment using photoplethysmogram (Preprint)
Authors: Shin Hangsik
Published: July 2021

BACKGROUND

Arterial stiffness due to vascular aging is a major indicator for evaluating cardiovascular risk.

OBJECTIVE

In this study, we propose a method of estimating age by applying machine learning to photoplethysmogram for non-invasive vascular age assessment.

METHODS

The machine learning-based age estimation model that consists of three convolutional layers and two-layer fully connected layers, was developed using segmented photoplethysmogram by pulse from a total of 752 adults aged 19–87 years. The performance of the developed model was quantitatively evaluated using mean absolute error, root-mean-squared-error, Pearson’s correlation coefficient, coefficient of determination. The Grad-Cam was used to explain the contribution of photoplethysmogram waveform characteristic in vascular age estimation.

RESULTS

Mean absolute error of 8.03, root mean squared error of 9.96, 0.62 of correlation coefficient, and 0.38 of coefficient of determination were shown through 10-fold cross validation. Grad-Cam, used to determine the weight that the input signal contributes to the result, confirmed that the contribution to the age estimation of the photoplethysmogram segment was high around the systolic peak.

CONCLUSIONS

The machine learning-based vascular aging analysis method using the PPG waveform showed comparable or superior performance compared to previous studies without complex feature detection in evaluating vascular aging.

CLINICALTRIAL

2015-0104
Text Feature Extraction of Health Science Information on Social Media—A Study based on the Text Sentiment and Statistical Evidence (Preprint)
Authors: Zhang Zuyue , Jiang Mengyao , Rao Qingmao , Wang Haolin , Ye Chunlv , Cheng Ting , Hou Xiaorong
Published: July 2021

BACKGROUND

There is a lot of health science information in social media. But most of the information lacks persuasive effect. Text features have a great influence on the information. Therefore, the text features of health science information in social media are studied.

OBJECTIVE

To investigate the text feature of health science information on social media and suggest ways to develop health science information on the basis of the research conclusions.

METHODS

Using Web crawler to collect the health science information data from WeChat official account, 4,645 myopia prevention texts of children in WeChat were collected, and 813 valid texts were included in the study. Through the analysis of text features, the text sentiment and the use of statistical evidence of health science information were extracted.

RESULTS

Results show that the use of commendatory words is obviously more than derogatory words (P < 0.01) and statistical evidence was used in over 96% of the text. Suggestions are put forward for the development of health science information in terms of text sentiment and statistical evidence.

CONCLUSIONS

This study investigated the emotional features of text and statistical evidence use features of health science information in social media. It is found that health information makers prefer positive emotions and use statistical evidence in most texts. Combined with previous research findings, we recommend greater usage of positive emotions and less of statistical evidence when formulating health information.
Subsurface Geology and Hydrothermal Alteration of The Patuha Geothermal Field, West Java: A Progress Report
Authors: Utama Peter Pratistha
Published: July 2021

Patuha geothermal field is one of the geothermal fields in West Java.  Developed by PT Geo Dipa Energi (Persero) since 2014, the geothermal field produced electricity, with installed capacity amounted to 55 MWe. Patuha geothermal system is vapour-dominated system. The geothermal manifestations are located at approximately 2,100 m asl. The Patuha field consists of three main upflow zones, namely Kawah Putih, Kawah Ciwidey, and Kawah Cibuni. This study analyzed the drill cuttings from 3 wells as the primary data with total depths ranging from 1,581 to 2,166 m with the well’s highest stable temperatures measured of ±230°C. The three wells selected for this research—PPL 02, PPL 04, and PPL 07—were analyzed to describe the rock properties and estimate the prospect areas of present-day geothermal exploration in Patuha. The objective of this paper is to develop a better understanding of the subsurface geology and its correlation to the dynamic processes (i.e., hydrothermal alteration) in Patuha geothermal field. The hydrothermal minerals are formed by near-neutral pH fluids and are characterized by quartz, calcite, clays (smectite, illite, chlorite), wairakite, epidote, and actinolite. The existence of acidic fluids is evident by the formation of acidic hydrothermal minerals e.g., anhydrite at various depth of the studied wells, particularly at PPL 07 which is located around Sugihmukti-Urug area. Moreover, the previous studies by Reyes (1990), Layman and Soemarinda (2003), Rachmawati et al. (2016), Elfina (2017) on hydrothermal minerals, geothermal manifestation characteristics, fluid geochemistry, and conceptual model are adapted to improve the analysis and interpretation of this paper.