bluuebunny/crossref_metadata_2025 huggingface dataset:
Forecasting Lake Nokoué Water Levels Using Long Short-Term Memory Network
Authors: Dabire Namwinwelbere , Ezin Eugene C. , Firmin Adandedji M.
Published: October 2024

The forecasting of hydrological flows (rainfall depth or rainfall discharge) is becoming increasingly important in the management of hydrological risks such as floods. In this study, the Long Short-Term Memory (LSTM) network, a state-of-the-art algorithm dedicated to time series, is applied to predict the daily water level of Lake Nokoué in Benin. This paper aims to provide an effective and reliable method to enable the reproduction of the future daily water level of Lake Nokoué, which is influenced by a combination of two phenomena: rainfall and river flow (runoff from the Ouémé River, the Sô River, the Porto-Novo lagoon, and the Atlantic Ocean). Performance analysis based on the forecasting horizon indicates that LSTM can predict the water level of Lake Nokoué up to a forecast horizon of t + 10 days. Performance metrics such as Root Mean Square Error (RMSE), coefficient of correlation (R2), Nash–Sutcliffe Efficiency (NSE), and Mean Absolute Error (MAE) agree on a forecast horizon of up to t + 3 days. The values of these metrics remain stable for forecast horizons of t + 1 day, t + 2 days, and t + 3 days. The values of R2 and NSE are greater than 0.97 during the training and testing phases in the Lake Nokoué basin. Based on the evaluation indices used to assess the model’s performance for the appropriate forecast horizon of water level in the Lake Nokoué basin, the forecast horizon of t + 3 days is chosen for predicting future daily water levels.
Health of Family Members of Road Transport Workers: Evaluation of Perceived Stress and Family Effectiveness
Authors: Lise Fernanda , Shattell Mona , Garcia Raquel Pötter , de Ávila Wilson Teixeira , Garcia Flávia Lise , Schwartz Eda
Published: October 2024

The health of road transport workers is affected by working conditions and life. However, there is a lack of studies on the level of stress and health of the families of these workers. This study aimed to evaluate the perceived stress level and family effectiveness of family members of road transport workers. A quantitative study was carried out with the family members of road transport workers in the southern region of Brazil. For data collection, a sociodemographic form, the Perceived Stress Scale (PSS), and the Evaluation of Family Effectiveness Strategies were used. The data were analyzed by simple frequency, Spearman correlation coefficient (ρ) (p < 0.05), and descriptive analysis from the perspective of Systemic Organization. The sample was composed of 49 family members of road transport workers. Perceived stress was higher in family members who had more than nine years of education (p = 0.0403). Family members who scored higher in Family Effectiveness scored high on the targets of Control (p = 0.0353) (Control aims to reduce anxiety and prevent and eliminate events that threaten family stability) and Growth (p = 0.0360) (represented by attitudes that promote new roles in response to critical situations experienced by families, which require re-adaptation processes and adjustments). The Control target was significant (p = 0.0353) in families that had more than three people. The Coherence dimension (concerning self-esteem, body image, personal identity, self-confidence, and sexual identity) presented positive significance (p = 0.0244) in families with health problems and whose income was less than USD 792.00 per month (p = 0.0072). The Individuation dimension (including functions and responsibilities, where talents are reinforced, as well as initiatives that allow for the incorporation of knowledge to assume behaviors against personal/family and environmental pressures), was significant (p = 0.0138) in families with incomes over USD 792.00. The Maintenance System (strategies for decision-making, problem negotiation, ritual and traditional roles, communication patterns, standards, financial management, and approaches to maintaining family harmony) presented positive significance (p = 0.0151) in families where drivers worked as intercity drivers, as did the Stability target (p = 0.0196) (concerning the continuity of routines, structure, organization, traditions, and values assumed by the family and transmitted from generation to generation, which promote unity and the development of values, attitudes, and beliefs). In conclusion, social factors, such as education, income, diseases, type of worker activity in road transport, and number of people in the family, influenced perceived stress and family effectiveness, which demonstrates the need to increase the promotion of health care for the families of road transport workers.
Improving the Prognostic and Predictive Value of Circulating Tumor Cell Enumeration: Is Longitudinal Monitoring the Answer?
Authors: Fabisiewicz Anna , Szostakowska-Rodzos Malgorzata , Grzybowska Ewa A.
Published: October 2024

Circulating tumor cell (CTC) numbers in the blood of cancer patients can indicate the progression and invasiveness of tumors, and their prognostic and predictive value has been repeatedly demonstrated. However, the standard baseline CTC count at the beginning of treatment, while informative, is not completely reliable and may not adequately reflect the state of the disease. A growing number of studies indicate that the long-term monitoring of CTC numbers in the same patient provides more comprehensive prognostic data and should be incorporated into clinical practice, as a factor that contributes to therapeutic decisions. This review describes the current status of CTC enumeration as a prognostic and predictive factor, highlights the shortcomings of current solutions, and advocates for longitudinal CTC analysis as a more effective method of the evaluation of developing disease, treatment efficacy, and the long term-monitoring of the minimal residual disease. As evidenced by the described reports, the longitudinal monitoring of CTCs should provide a better and more sensitive prediction of the course of the disease, and its incorporation in clinical practice should be beneficial.
Exploring a Potential Optimization Route for Peptide Ligands of the Sam Domain from the Lipid Phosphatase Ship2
Authors: Vincenzi Marian , Mercurio Flavia Anna , La Manna Sara , Palumbo Rosanna , Pirone Luciano , Marasco Daniela , Pedone Emilia Maria , Leone Marilisa
Published: October 2024

The Sam (Sterile alpha motif) domain of the lipid phosphatase Ship2 (Ship2-Sam) is engaged by the Sam domain of the receptor tyrosine kinase EphA2 (EphA2-Sam) and, this interaction is principally linked to procancer effects. Peptides able to hinder the formation of the EphA2-Sam/Ship2-Sam complex could possess therapeutic potential. Herein, by employing the FoldX software suite, we set up an in silico approach to improve the peptide targeting of the so-called Mid Loop interface of Ship2-Sam, representing the EphA2-Sam binding site. Starting from a formerly identified peptide antagonist of the EphA2-Sam/Ship2-Sam association, first, the most stabilizing mutations that could be inserted in each peptide position were predicted. Then, they were combined, producing a list of potentially enhanced Ship2-Sam ligands. A few of the in silico generated peptides were experimentally evaluated. Interaction assays with Ship2-Sam were performed using NMR and BLI (BioLayer Interferometry). In vitro assays were conducted as well to check for cytotoxic effects against both cancerous and healthy cells, and also to assess the capacity to regulate EphA2 degradation. This study undoubtedly enlarges our knowledge on how to properly target EphA2-Sam/Ship2-Sam associations with peptide-based tools and provides a promising strategy that can be used to target any protein–protein interaction.
Metabolic Syndrome, Thyroid Dysfunction, and Cardiovascular Risk: The Triptych of Evil
Authors: Pingitore Alessandro , Gaggini Melania , Mastorci Francesca , Sabatino Laura , Cordiviola Linda , Vassalle Cristina
Published: October 2024

The triad formed by thyroid dysfunction, metabolic syndrome (MetS), and cardiovascular (CV) risk forms a network with many connections that aggravates health outcomes. Thyroid hormones (THs) play an important role in glucose and lipid metabolism and hemodynamic regulation at the molecular level. It is noteworthy that a bidirectional association between THs and MetS and their components likely exists as MetS leads to thyroid dysfunction, whereas thyroid alterations may cause a higher incidence of MetS. Thyroid dysfunction increases insulin resistance, the circulating levels of lipids, in particular LDL-C, VLDL-C, and triglycerides, and induces endothelial dysfunction. Furthermore, THs are important regulators of both white and brown adipose tissue. Moreover, the pathophysiological relationship between MetS and TH dysfunction is made even tighter considering that these conditions are usually associated with inflammatory activation and increased oxidative stress. Therefore, the role of THs takes place starting from the molecular level, then manifesting itself at the clinical level, through an increased risk of CV events in the general population as well as in patients with heart failure or acute myocardial infarction. Thus, MetS is frequently associated with thyroid dysfunction, which supports the need to assess thyroid function in this group, and when clinically indicated, to correct it to maintain euthyroidism. However, there are still several critical points to be further investigated both at the molecular and clinical level, in particular considering the need to treat subclinical dysthyroidism in MetS patients.
Intrathecal Immunoselective Nanopheresis for Alzheimer’s Disease: What and How? Why and When?
Authors: Menendez-Gonzalez Manuel
Published: October 2024

Nanotechnology is transforming therapeutics for brain disorders, especially in developing drug delivery systems. Intrathecal immunoselective nanopheresis with soluble monoclonal antibodies represents an innovative approach in the realm of drug delivery systems for Central Nervous System conditions, especially for targeting soluble beta-amyloid in Alzheimer’s disease. This review delves into the concept of intrathecal immunoselective nanopheresis. It provides an overall description of devices to perform this technique while discussing the nanotechnology behind its mechanism of action, its potential advantages, and clinical implications. By exploring current research and advancements, we aim to provide a comprehensive understanding of this novel method, addressing the critical questions of what it is, how it works, why it is needed, and when it should be applied. Special attention is given to patient selection and the optimal timing for therapy initiation in Alzheimer’s, coinciding with the peak accumulation of amyloid oligomers in the early stages. Potential limitations and alternative targets beyond beta-amyloid and future perspectives for immunoselective nanopheresis are also described.
Cardiovascular Disease May Be Triggered by Gut Microbiota, Microbial Metabolites, Gut Wall Reactions, and Inflammation
Authors: Dicks Leon M. T.
Published: October 2024

Cardiovascular disease (CVD) may be inherited, as recently shown with the identification of single nucleotide polymorphisms (SNPs or “snips”) on a 250 kb DNA fragment that encodes 92 proteins associated with CVD. CVD is also triggered by microbial dysbiosis, microbial metabolites, metabolic disorders, and inflammatory intestinal epithelial cells (IECs). The epithelial cellular adhesion molecule (Ep-CAM) and trefoil factor 3 (TFF3) peptide keeps the gut wall intact and healthy. Variations in Ep-CAM levels are directly linked to changes in the gut microbiome. Leptin, plasminogen activator inhibitor 1 (PAI1), and alpha-1 acid glycoprotein 1 (AGP1) are associated with obesity and may be used as biomarkers. Although contactin 1 (CNTN1) is also associated with obesity and adiposity, it regulates the bacterial metabolism of tryptophan (Trp) and thus appetite. A decrease in CNTN1 may serve as an early warning of CVD. Short-chain fatty acids (SCFAs) produced by gut microbiota inhibit pro-inflammatory cytokines and damage vascular integrity. Trimethylamine N-oxide (TMAO), produced by gut microbiota, activates inflammatory Nod-like receptors (NLRs) such as Nod-like receptor protein 3 (NLRP3), which increase platelet formation. Mutations in the elastin gene (ELN) cause supra valvular aortic stenosis (SVAS), defined as the thickening of the arterial wall. Many of the genes expressed by human cells are regulated by gut microbiota. The identification of new molecular markers is crucial for the prevention of CVD and the development of new therapeutic strategies. This review summarizes the causes of CVD and identifies possible CVD markers.
Prevalence and Mutation Analysis of Short-Chain acyl-CoA Dehydrogenase Deficiency Detected by Newborn Screening in Hefei, China
Authors: Hu Haili , Ma Qingqing , Li Weidong , Wang Yan , Song Wangsheng , Huang Yong
Published: October 2024

Short-chain acyl-CoA dehydrogenase deficiency (SCADD) is an autosomal recessive inborn error of mitochondrial fatty acid oxidation with highly variable biochemical and genetic characteristics. The present study aimed to estimate the prevalence and genetic characteristics of SCADD in newborns identified through screening. A total of 782,930 newborns were screened for SCADD in Hefei Neonatal Screening Center from January 2016 to December 2023. The blood samples from newborns were measured by tandem mass spectrometry (MS/MS). The suspected SCADD neonates were rechecked using next-generation gene sequencing for diagnosis. Sanger sequencing was used to verify the mutation site for patients with SCADD and their parents. A total of 21 SCADD cases were confirmed, with an incidence rate of 1/37,282. Genetic mutations were identified in all 21 cases, including 15 cases of compound heterozygous variation and 6 cases of homozygous variation. Twenty-one different mutation types and forty-two mutation sites were discovered, with the most frequent mutation being c.1031A>G, accounting for 21.43% (9/42), followed by c.1130C>T, accounting for 16.67% (7/42). Our findings expand the SCADD mutational spectra. c. 1031A>G and c.1130C>T are the common mutation sites for SCADD genes in newborns. SCADD diagnosed through NBS is primarily a benign condition, and early diagnosis is not necessarily essential.
A Host Tree and Its Specialist Insects: Black Locust (Robinia pseudoacacia) Availability Largely Determines the Future Range Dynamics of Its Specialist Insects in Europe
Authors: Zhang Xueyou , Nie Peixiao , Hu Xiaokang , Feng Jianmeng
Published: October 2024

Black locust is the only host of Robinia-specialist insects in Europe. However, no study to date has examined future range shifts of specialist insects, and the relative effects of host plant availability and other factors on their range shifts. Here, we characterized the future range shifts in the host and its four specialist insects and the factors contributing to changes in their ranges. We detected substantial range expansions in all target species. Climate predictors and host plant availability were expected to have the strongest effects on the range shifts in the host and its specialist insects, respectively, suggesting that the specialist insects will track the ranges of their host. Parectopa robiniella showed the largest potential and expanding ranges and should be made a priority species for controlling invasions of Robinia-specialist insects in Europe. The expanding ranges of all specialist species were largely identified in the United Kingdom, Germany, and France, suggesting that these should be priority regions for mitigating their effects on ecosystems. Reducing future climate change is essential for preventing the spreading of specialist insects in Europe since specialist insects track their specialist host plants, and host range expansions are mainly driven by future climate changes.
Impact of Conversion from Conventional Pemafibrate to Novel Pemafibrate XR on Hypertriglyceridemia: An Observational Retrospective Study
Authors: Hida Yuki , Imamura Teruhiko , Kinugawa Koichiro
Published: October 2024

Background: Pemafibrate is a novel selective peroxisome proliferator-activated receptor-α modulator, which was demonstrated to reduce serum triglyceride levels with few drug-related adverse events in several clinical studies, as well as phase II and III clinical trials. One of the limitations of this medicine was the requirement of twice-daily oral administration, resulting in reduced medication adherence, particularly in elderly patients, who are rather good targets for this medicine. Recently, a once-daily extended-release (XR) tablet has been introduced. Given an improvement in medication adherence, the therapeutic efficacy of pemafibrate may be enhanced. Methods: Patients with hypertriglyceridemia, in whom conventional twice-daily immediate-release (IR) pemafibrate was converted to pemafibrate XR between 2023 and 2024, were eligible. Each type of tablet was prescribed for three months, respectively. A dose change was not attempted. The serum triglyceride levels were compared between 3 months pre-conversion and 3 months post-conversion using a Friedman test and a post hoc Wilcoxon signed-rank test. Results: A total of 46 patients were included. The median age was 62 years, and 29 were men. IR was continued for 698 (280, 1183) days before the conversion. During the last 3-month IR therapy, serum triglyceride levels remained unchanged from 171 (138, 239) mg/dL to 181 (123, 245) mg/dL (p = 0.78). Following the conversion, no patients had drug-related adverse events, and all patients completed 3-month XR therapy. At three months after the conversion, the serum triglyceride levels decreased significantly from 181 (123, 245) mg/dL to 146 (107, 184) mg/dL (p < 0.001). Conclusions: Pemafibrate XR might be a more promising medication than conventional IR in improving hypertriglyceridemia, probably due to improved medication adherence.
Real-World Efficacy of Biological Therapies in Severe Asthma: A Focus on Small Airways
Authors: Ora Josuel , De Marco Patrizia , Motta Enrico , Laitano Rossella , Calzetta Luigino , Rogliani Paola
Published: October 2024

Background: Severe asthma is a challenging condition that often resists traditional treatments and requires high-dose inhaled corticosteroids and other controllers to manage uncontrolled symptoms. Recent advances include the use of biologic agents targeting specific inflammation pathways, which have improved symptom control and quality of life, although their effects on small airways remain less understood. Methods: This prospective observational study, conducted at Tor Vergata University Hospital in Rome from July 2021 to March 2024, aims to evaluate the efficacy of treatments in patients with uncontrolled severe asthma. It involves baseline assessments and follow-ups at 1 and 3 months post-biological therapy initiation, focusing on both spirometric and non-spirometric (oscillometry) measurements of the small airways to provide a comprehensive evaluation of respiratory function. Results: This study, conducted from July 2021 to March 2024, enrolled 40 patients with severe asthma, ultimately analyzing data from 31 participants who underwent biological therapy. The results showed significant improvements in asthma symptoms, the ACT scores increased significantly from visit 1 to visit 2 (p = 0.00008) and from visit 1 to visit 3 (p = 0.00047), and pulmonary function tests, with notable increases in FEV1 (from visit 1 (74.97 ± 23.43%) to visit 2 (82.96 ± 26.57%, p = 0.041) and to visit 3 (88.89 ± 31.41%, p = 0.003)) and quality of life scores, and substantial reductions in specific airway resistance and small airway dysfunction markers (the PEF, %pr post-BD showed significant improvement from visit 1 to visit 3 (p = 0.012)). However, oscillometric measurements showed no significant changes post-therapy. Conclusions: The study concluded that there was an improvement in the small airways measured by non-oscillometric values, without significant improvements in oscillometric parameters. Additionally, a significant improvement in symptoms was observed after the first month of therapy. There was also a significant increase in respiratory function after one to three months of therapy.
Is an Electronic Nose Able to Predict Clinical Response following Neoadjuvant Treatment of Rectal Cancer? A Prospective Pilot Study
Authors: Schoenaker Ivonne J. H. , Pennings Alexander , van Westreenen Henderik L. , Finnema Evelyn J. , Brohet Richard M. , Hanevelt Julia , de Vos Tot Nederveen Cappel Wouter H. , Melenhorst Jarno
Published: October 2024

Introduction: A watch-and-wait strategy for patients with rectal cancer who achieve a clinical complete response after neoadjuvant (chemo) radiotherapy is a valuable alternative to rectal resection. In this pilot study, we explored the use of an electronic nose to predict response to neoadjuvant therapy by analyzing breath-derived volatile organic compounds. Materials and Methods: A pilot study was performed between 2020 and 2022 on patients diagnosed with intermediate- or high-risk rectal cancer who were scheduled for neoadjuvant therapy. Breath samples were collected before and after (chemo) radiotherapy. A machine-learning model was developed to predict clinical response using curatively treated rectal cancer patients as controls. Results: For developing the machine-learning model, a total of 99 patients were included: 45 patients with rectal cancer and 54 controls. In the training set, the model successfully discriminated between patients with and without rectal cancer, with a sensitivity and specificity of 0.80 and 0.65, respectively, and an accuracy of 0.72. In the test set, the model predicted partial or (near) complete response with a sensitivity and specificity of 0.64 and 0.47, respectively, and an accuracy of 0.58. The AUC of the ROC curve was 0.63. Conclusions: The prediction model developed in this pilot study lacks the ability to accurately differentiate between partial and (near) complete responders with an electronic nose. Machine-learning studies demand a substantial number of patients and operate in a rapidly evolving field. Therefore, the prevalence of disease and duration of a study are crucial considerations for future research.
Investigation of Tribological Behavior of PTFE Composites Reinforced with Bronze Particles by Taguchi Method
Authors: Ficici Ferit , Ozdemir Ismail , Grund Thomas , Lampke Thomas
Published: October 2024

Reinforced PTFE materials can be designed to show high mechanical stability against harder materials under sliding wear conditions. Especially bearing metal-reinforced PTFE is of high practical interest. In this class of materials, bronze-filled PTFE was reported to obtain high wear resistance, a low coefficient of friction (COF), and excellent self-lubrication properties in sliding conditions. In the statistical approach of this work, PTFE composites reinforced with 25 vol%, 40 vol%, and 60 vol% bronze particles were evaluated against pure PTFE regarding wear behavior under varied wear test parameters, i.e., material, normal load, and sliding speed. Wear tests were planned to use a standard orthogonal array based on the Taguchi design method. An analysis of variance test was utilized to quantify the effects of test parameters on the wear behavior of the bronze/PTFE composites and pure PTFE. According to the variance analysis, the material type has the largest influence on the COF and the specific wear rate (SWR) under test conditions of this work. Both COF and SWR were found to be influenced by the material type (29.83% and 96.16%), the normal load (33.34% and 0.95%), and sliding speed (9.14% and 1.28%). The lowest SWR and COF values were achieved at the optimum wear test conditions where the wear test parameters were 1 m/s sliding speed (A4B2C2) at PTFE + 60 vol.% bronze reinforced composite 50 N application load and 0.32 m/s sliding speed (A4B3C1) at PTFE + 60 vol.% bronze reinforced composite 100 N application load, respectively.
Extrusion and Injection Molding of Polyethylene Loaded with Recycled Textiles: Mechanical Performance and Thermal Conductivity
Authors: Gasselin Mateo , Kalantar Adib , Karlsson Sofi , Leisner Peter , Skrifvars Mikael , Khalili Pooria
Published: October 2024

The aim of this project was to assess the thermal conductivity of polyethylene (PE) filled with carbon black (CB), specifically for geothermal pipes. The project explored the potential modification of PE’s thermal conductivity by incorporating recycled textile fibers. Different types of shredded recycled fibers were tested, including two types of polyamide fibers with varying contaminations and one type of polyester fiber. Following several preparation steps, various composite materials were manufactured and compared to bulk PE using various testing methods: Differential Scanning Calorimetry analysis (DSC), mechanical testing (flexural and tensile), and laser flash analysis (LFA). The results revealed alterations in the mechanical properties of the composite materials in comparison to PE filled with CB. The LFA tests demonstrated the effectiveness in reducing polymer thermal diffusivity at higher temperatures, particularly when the material was loaded with recycled polyester fillers.
Tuning of Particle Size of Zeolitic Imidazolate Framework-7 via Rapid Synthesis Duration for CH4 Adsorption
Authors: Chai Li-Xing (Joey) , Abd Rahman Alia Syuhada , Yeong Yin Fong
Published: October 2024

In this work, zeolite imidazolate framework-7 (ZIF-7) nanoparticles are synthesized via a solvothermal method and rapid synthesis durations of 1 h and 3 h. The effect of the synthesis duration on the structural properties of ZIF-7 was characterized by XRD and FESEM analyses. Subsequently, CH4 single gas adsorption over ZIF-7 nanoparticles was examined using the volumetric method at room temperature and pressure ranging from 2 to 9 bar. The results showed that the synthesized ZIF-7 adsorbents were highly crystalline with a well-defined and homogeneous particle size distribution of 50–60 nm. It was found that increasing the synthesis duration from 1 h to 3 h did not amend the structure and morphology of the resultant samples significantly, mainly due to the short synthesis duration. Meanwhile, the CH4 adsorbed by ZIF-7 nanoparticles increased with rising pressure for both samples, and the ZIF-7 nanoparticles synthesized at 3 h showed a greater adsorption capacity than that of 1 h, mainly due to its higher crystallinity and well-developed pore structure. The ZIF-7 synthesized at 3 h demonstrated an adsorption capacity up to 2.2 mol/kg, which was higher than those values reported in the literature for micron-sized ZIF-7 samples. The CH4 gas adsorption behavior of ZIF-7 nanoparticles synthesized at 1 h and 3 h were well predicted by the Langmuir isotherm model, with coefficients of determination, R2, of 0.9994 and 0.9982, respectively.
Effect of Outdoor Cycling, Virtual and Enhanced Reality Indoor Cycling on Heart Rate, Motivation, Enjoyment and Intention to Perform Green Exercise in Healthy Adults
Authors: Poli Luca , Greco Gianpiero , Gabriele Michele , Pepe Ilaria , Centrone Claudio , Cataldi Stefania , Fischetti Francesco
Published: October 2024

Background: Despite the benefits of physical activity (PA), Italy ranks low in leisure-time PA among European countries. Integrating virtual (VR)/enhanced (ER) reality with exercise equipment could boost PA engagement. Limited studies have explored how VR/ER-integrated cycling activity, compared to outdoor settings, influences PA among university students. Therefore, this study aimed to evaluate the acute effects of a brief cycling session outdoors and indoors on psychological and physiological outcomes, and secondly, investigate the potential of VR/ER-mediated nature experiences as a tool to promote green exercise. Methods: In February 2024, thirty-one subjects (20 M and 11 F; age 24.3 ± 3.2 years; BMI 23.5 ± 3.6 kg/m2) were involved in this randomized crossover-controlled trial, where they were assigned to three different conditions: ER cycling (ERC), VR cycling (VRC), and outdoor cycling (OUTC). Heart rate (HR), Physical Activity Enjoyment (PACE), Intrinsic Motivation Inventory (IMI), and Intention to Perform Green Exercise (INT-GE) were assessed at the end of each condition. Results: The OUTC condition showed significantly greater PACE, IMI, and INT-GE than ERC/VRC (p < 0.001), lower HRmean than ERC/VRC (p < 0.001 and p < 0.05, respectively), and lower HRmax than ERC (p < 0.05). Conclusions: VRC and ERC enhanced engagement and physiological responses during indoor cycling, but outdoor cycling offered superior benefits in motivation, enjoyment, and future engagement intentions. No significant differences were found between VRC and ERC in promoting intentions for outdoor activities, suggesting both technologies could be equally effective.
The Dispersion-Strengthening Effect of TiN Nanoparticles Evoked by Ex Situ Nitridation of Gas-Atomized, NiCu-Based Alloy 400 in Fluidized Bed Reactor for Laser Powder Bed Fusion
Authors: Roth Jan-Philipp , Šulák Ivo , Gálíková Markéta , Duval Antoine , Boissonnet Germain , Pedraza Fernando , Krupp Ulrich , Jahns Katrin
Published: October 2024

Throughout recent years, the implementation of nanoparticles into the microstructure of additively manufactured (AM) parts has gained great attention in the material science community. The dispersion strengthening (DS) effect achieved leads to a substantial improvement in the mechanical properties of the alloy used. In this work, an ex situ approach of powder conditioning prior to the AM process as per a newly developed fluidized bed reactor (FBR) was applied to a titanium-enriched variant of the NiCu-based Alloy 400. Powders were investigated before and after FBR exposure, and it was found that the conditioning led to a significant increase in the TiN formation along grain boundaries. Manufactured to parts via laser-based powder bed fusion of metals (PBF-LB/M), the ex situ FBR approach not only revealed a superior microstructure compared to unconditioned parts but also with respect to a recently introduced in situ approach based on a gas atomization reaction synthesis (GARS). A substantially higher number of nanoparticles formed along cell walls and enabled an effective suppression of dislocation movement, resulting in excellent tensile, creep, and fatigue properties, even at elevated temperatures up to 750 °C. Such outstanding properties have never been documented for AM-processed Alloy 400, which is why the demonstrated FBR ex situ conditioning marks a promising modification route for future alloy systems.
Structural and Reservoir Characteristics of Potential Carbon Dioxide Storage Sites in the Northern South Yellow Sea Basin, Offshore Eastern China
Authors: Luo Di , Yuan Yong , Chen Jianwen , Li Qing , Liang Jie , Zhao Hualin
Published: October 2024

The geological storage of carbon dioxide (CO2) in offshore saline aquifers stands as a primary option for reducing CO2 emissions in coastal regions. China’s coastal regions, particularly Shandong and Jiangsu provinces, face significant challenges in CO2 reduction. Therefore, evaluating the feasibility of CO2 geological storage in the adjacent seas is critical. To assess the suitability of a CO2 storage site, understanding its structural and reservoir characteristics is essential to mitigate injection and storage risks. In this study, we analyzed the structural characteristics and potential traps of the Yantai Depression in the South Yellow Sea Basin based on seismic data interpretation. We further conducted well logging analysis and post-stack seismic inversion to obtain lithological data, including acoustic impedance and sandstone content percentages from the Cenozoic Funing Formation, Dainan–Sanduo Formation, and Yancheng Formation. Our findings highlight that the Yantai Depression in the South Yellow Sea Basin exhibits diverse structural traps and favorable reservoir–caprock combinations, suggesting promising geological conditions for CO2 storage. This area emerges as a suitable candidate for implementing CO2 geological storage initiatives.
Numerical Evaluation of Wave Dissipation on a Breakwater Slope Covered by Precast Blocks with Different Geometrical Characteristics
Authors: Jiao Bowen , Zhao Qingli , Chen Fang , Liu Chunhui , Fang Qinghe
Published: October 2024

Slopes suffer damage from waves in coastal environments. Precast blocks with well-designed geometrical characteristics can benefit the construction of revetments by mitigating the issue of wave overtopping and dissipating wave energy. In this study, we numerically studied the effect of the geometrical characteristics of precast blocks on wave overtopping by carrying out a numerical simulation of wave overtopping on a slope covered with precast blocks. A total of three different types of blocks were considered in this study to determine the optimal geometric shape using a validated numerical model. Our numerical investigation demonstrated that the roughness of the precast block plays an important role in lessening the height of the wave run-up. Concave and embedded regular hexagons could reduce the wave run-up height by 44.6% compared with smooth slopes within a 2 s wave period. Herein, we evaluate and discuss the influence of the geometrical characteristics of a given precast block, such as thickness, aperture, and wave dissipation notch, on wave run-up. We also present an empirical formula for predicting wave run-up on a slope covered by a concave and embedded regular hexagon-type prefabricated block. This study provides valuable insights into the design of prefabricated revetment blocks.
Tuft Dynamics and the Reproductive Phenology of Zostera caespitosa on the Southern Coast of Korea
Authors: Im Dahyeok , Kim Seung Hyeon , Kim Hyegwang , Suonan Zhaxi , Zhang Fei , Song Hwi-June , Lee Kun-Seop
Published: October 2024

The aim of study is to determine which environmental factors could influence the biological traits of Z. caespitosa, a unique tuft-forming seagrass. This study examined the dynamics of tufts and the growth of Z. caespitosa, along with the environmental factors. The reproductive traits were also examined to estimate the potential importance of sexual reproduction in population persistence. The density of tufts remained constant, and no new tufts produced through seedling recruitment were observed throughout the sampling period. On the other hand, the tuft size and growth exhibited clear seasonal manners and strong correlations with the water temperature, indicating that water temperature regulates the tuft dynamics and growth. The optimal growth temperature for Z. caespitosa at the study site was approximately ~22.5 °C during early summer, with growth severely inhibited during periods of high-water temperatures. Z. caespitosa was characterized by a low flowering percentage and fewer inflorescences, resulting in extremely low potential seed production. Z. caespitosa maintained its populations through clonal tuft growth with low sexual reproduction and restricted growth at high water temperatures. Hence, this seagrass species may be vulnerable to disturbances, exhibiting low resilience and facing a high risk of becoming a threatened species in coastal waters.
Vessel Trajectory Prediction at Inner Harbor Based on Deep Learning Using AIS Data
Authors: Shin Gil-Ho , Yang Hyun
Published: October 2024

This study aims to improve vessel trajectory prediction in the inner harbor of Busan Port using Automatic Identification System (AIS) data and deep-learning techniques. The research addresses the challenge of irregular AIS data intervals through linear interpolation and focuses on enhancing the accuracy of predictions in complex port environments. Recurrent neural network (RNN), Long Short-Term Memory (LSTM), Bidirectional LSTM, Gated Recurrent Unit (GRU), and Bidirectional GRU models were developed, with LSTM delivering the highest performance. The primary scientific question of this study is how to reliably predict vessel trajectories under varying conditions in inner harbors. The results demonstrate that the proposed method not only improves the precision of predictions but also identifies critical areas where Vessel Traffic Service Operators (VTSOs) can better manage vessel movements. These findings contribute to safer and more efficient vessel traffic management in ports with high traffic density and complex navigational challenges.
Research Progress on Preparation of Superhydrophobic Surface and Its Application in the Field of Marine Engineering
Authors: Fu Jingguo , Liao Xiaogang , Ji Yulong , Mo Yanqiang , Zhang Jifeng
Published: October 2024

Inspired by the “Lotus Leaf Effect” in nature, the phenomenon of superhydrophobia has attracted tremendous attention from researchers. Due to their special surface wettability, the superhydrophobic surfaces have been found to have broad potential applications in the fields of marine engineering, medical equipment, and aerospace. Based on the introduction of the principles of wettability, the advantages and disadvantages of various preparation methods for superhydrophobic surfaces were studied and summarized in this paper. The research progress on superhydrophobic surfaces in marine engineering applications was analyzed according to their self-cleaning, anti-corrosion, heat transfer, drag reduction, anti-fouling, ant-icing, and oil/water separation properties. Finally, to advance practical applications, the current challenges associated with superhydrophobic surfaces are highlighted, and potential future development directions are proposed.
Lessons from the Pilot Project of Korean ETS on the Local Landscape of Economy
Authors: Choi Yongrok , Tang Ziqian , Ma Yunning
Published: October 2024

For a sustainable landscape of local economies, many researchers have emphasized the importance of field-oriented differentiation in government policies. In particular, the Paris Agreement, based on the bottom-up approach, aims to maximize the participation of all economic agents, in contrast to the top-down approach of the Tokyo Protocol. In response to these global paradigm shifts in the local landscape, local governments in Korea have made significant efforts to adapt to sustainable development during the pilot phase of emission trading scheme (ETS), during the period from 2015 to 2020. This study evaluates the performance of these local government policies in the transition to a carbon-zero economy. Using the general non-radial directional distance function (GNDDF), we found that Gyeongsang Province demonstrated enhanced environmental total factor productivity (TFP) during the pilot project, whereas the Seoul metropolitan area lagged behind due to a lack of governance. As the economic center of Korea, Seoul showed poor environmental performance because of the arbitrary elimination of green belt areas and unchecked land development, resulting in environmental degradation, a trend common in many developing countries facing climate adaptation challenges. To address these urbanization issues, this study concludes that a balanced approach combining stricter regulations with market-oriented promotional incentives is essential for optimizing the transition of local economies to a sustainable landscape.
Chemical Bonds Formed in Solid Wood by Reaction with Maleic Anhydride and Sodium Hypophosphite
Authors: Kim Injeong , Antzutkin Oleg N. , Shah Faiz Ullah , Karlsson Olov , Jones Dennis , Sandberg Dick
Published: October 2024

The reaction of wood with maleic anhydride (MA) and sodium hypophosphite (SHP) has been identified as a viable modification method, with macroscopical properties indicating formation of cross-linking to explain the results. However, the chemical reaction between wood and the modification reagents has not been studied yet. To resolve this, the reaction was studied with solid-state 13C cross-polarization magic-angle-spinning (CP-MAS) and 31P MAS nuclear magnetic resonance (NMR) and X-ray photoelectron spectroscopy (XPS) to reveal the formation of bonds between wood components, MA and SHP during the treatments to explain the formation of cross-linking and the possible fixation of phosphorus in wood. XPS, solid state 13C and 31P MAS NMR revealed the maleation of wood in the absence of SHP, whilst its presence led to forming a succinic adduct observed through the C-P bond formation, as evidenced by the loss of the maleate C=C bonds at around 130 ppm and the upfield shift of the peak at 165–175 ppm, which was also significantly smoothed, as well as the increase in a peak at 26 ppm due to the reaction between the maleate group and SHP; however, the C-P-C bond could not be unambiguously rationalized from the obtained data. On the other hand, a resonance line at 16 ppm in 31P MAS NMR and the peaks in the XPS P 2p spectrum suggested the formation of a cross-linked structure at low concentrations of SHP, which was more likely to be phosphonate (C-P-O) than organophosphinic acid (C-P-C). The results herein provide a greater fundamental understanding of the mechanisms involved in the reaction of wood, MA and SHP, providing further scope for improved treatment systems in the future.
Optimization of the Microstructure and Mechanical Properties of a TC4 Alloy Joint Brazed with a Zr-Based Filler Containing a Co Element
Authors: Sun Zhan , Yu Deshui , Zhang Lixia , Sun Mingjia , Zhang Boyu , Long Weimin , Zhong Sujuan
Published: October 2024

Herein, we fabricated a low-melting-point Zr-16Ti-6Cu-8Ni-6Co eutectic filler based on a Zr-Ti-Cu-Ni filler to achieve effective joining of a Ti6Al4V (TC4) titanium alloy. The temperature at which the brittle intermetallic compound (IMC) layer in the seam completely disappeared was reduced from 920 °C to 900 °C, which broadened the temperature range of the Zr-based filler, brazing the TC4 without a brittle IMC layer. The shear strength of the Zr-16Ti-6Cu-8Ni-6Co brazed joint increased by 113% more than that of the Zr-16Ti-9Cu-11Ni brazed joint at 900 °C. The proportion of β-Ti in the seam of the Zr-16Ti-6Cu-8Ni-6Co brazed joint increased by 21.31% compared with that of the Zr-16Ti-9Cu-11Ni brazed joint. The nano-indentation results show that the elastic modulus of the β-Ti (143 GPa) in the interface is lower than that of the α-Ti (169 GPa) and (Ti,Zr)2(Ni,Cu,Co) (203 GPa). As a result, the β-Ti is subjected to a greater strain under the same stress state compared with the α-Ti and (Ti,Zr)2(Ni,Cu,Co), and the Zr-16Ti-6Cu-8Ni-6Co brazed joint can maintain a higher strength than the Zr-16Ti-9Cu-11Ni brazed joint under a middle–low erosion area of the TC4 base metal. This provides valuable insights into the use of high-strength, fatigue-resistant TC4 brazed joints in engineering applications.
Significantly Enhanced Corona Resistance of Epoxy Composite by Incorporation with Functionalized Graphene Oxide
Authors: Yang Yue , Wang Yumin , He Chunqing , Wang Zheng , Peng Xiangyang , Fang Pengfei
Published: October 2024

Enhancing the corona resistance of epoxy resin (EP) is crucial for ensuring the reliable operation of electrical equipment and power systems, and the incorporation of inorganic nanofillers into epoxy resin has shown significant potential in achieving this. In this study, functionalized graphene oxide (KHGO) was synthesized via a sol-gel method to enhance the corona resistance of EP with electrochemical impedance spectroscopy (EIS) used to assess the properties of KHGO/EP composites. Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS) verified the successful grafting of epoxy groups onto the GO surface. The thermal conductivity and stability of the KHGO/EP composite initially increased with KHGO content but declined when the content exceeded 1.2 wt.%. Positron annihilation lifetime spectroscopy (PALS) indicated that KHGO improved interfacial compatibility with EP compared to GO, with agglomeration occurring when KHGO content exceeded a threshold value (1.2 wt.%). EIS analysis revealed that the corona resistance of the KHGO/EP composite was optimal at a filler content of 0.9 wt.%. After corona treatment, the saturation water uptake of the 0.9 wt.% KHGO/EP composite decreased by 15% compared to pure EP with its porosity reduced to just 1/40th of that of pure EP. This study underscores that well-dispersed KHGO/EP composite exhibits excellent corona resistance property suggesting the potential for industrial applications in high-voltage equipment insulation.
Hierarchical Control in Mechatronic Technological Systems
Authors: Lishchenko Natalia , Gushchin Anatoly , Larshin Vasily
Published: October 2024

The topic of hierarchical control of technological machines is one of the most relevant in mechanical engineering technology. The most difficult issue in this area is the organization of interactions between different control levels, on the one hand, and the choice of automatic control methods for each of these control levels (control by deviation, control by disturbance, mixed control, etc.), on the other. In this article, in relation to machining technology, a method and corresponding device are proposed that make it possible to implement the control of cutting force parameters (axial cutting force and cutting torque) in an automatic control system for the deviation of cutting torque by changing the axial cutting force (lower level of control). The lower-level control ensures the required quality of the surface layer (surface integrity) of the machined parts. At the same time, the required dimensional accuracy of parts is ensured at the upper level of control, which is implemented by the CNC system of the machine. At the upper level, automatic control is carried out based on the deviation of the kinematic parameters of the movement of the working parts of the CNC machine (acceleration, speed, displacement). Control switching from upper to lower level and back is carried out without using a spindle linear axial movement sensor. Instead of this expensive sensor, a limit switch (a closed and opened pair of contacts) is used, which fixes the lowest axial position of the spindle (and cutting tool). Based on the signal of closing the specified contacts of the limit switch, a transition from the lower control level to the upper one is carried out. Thus, the upper-level system operates only when these contacts are closed, and the lower-level system operates only when they are open. In relation to the upper-level system, the lower-level control system implements the control “by disturbance” principle, also known in control theory as the “disturbance compensation principle”.
Finite-Time Adaptive Control for Electro-Hydraulic Braking Gear Transmission Mechanism with Unilateral Dead Zone Nonlinearity
Authors: Cao Qinghua , Wu Jian , Xu Fuxing , Miao Xinhong , Guo Mingjie , Chu Yuan
Published: October 2024

Autonomous vehicles require more precise and reliable braking control, and electro-hydraulic braking (EHB) systems are better adapted to the development of autonomous driving. However, EHB systems inevitably suffer from unilateral dead zone nonlinearity, which adversely affects the position tracking control. Therefore, a finite-time adaptive control strategy was designed for unilateral dead zone nonlinearity. Initially, the unilateral dead zone nonlinearity was reformulated into a matched disturbance term and an unmatched disturbance term to reduce the adverse effects of disturbances, thereby enhancing system controllability. Then, the “complexity explosion” in the design of the control strategy was avoided by command filtering, and the design process of the controller was simplified. Furthermore, the finite-time control theory was employed to boost the system’s convergence speed, thereby enhancing control performance. In order to ensure the stability of the system under the dead zone disturbance, the unknown disturbance terms were estimated. The stability of the control strategy was validated through the finite-time stability theorem and the Lyapunov function. Eventually, simulations and hardware-in-the-loop (HIL) experiments validated the feasibility and availability of the finite-time adaptive control strategy.