bluuebunny/crossref_metadata_2025 huggingface dataset:
Thickness distribution peculiarities of DLS –films obtained by method of pulse laser precipitation
Authors: Shupenev Alexandr , Krivosheev Alexandr , Ponomarenko Svetlana
Published: January 2020

One of the promising methods of thin film manufacturing is a method of pulse laser precipitation. By virtue of energetic peculiarities of laser impact upon a target this method is widely used at the formation of diamond-like structures. The manufacture of diamond-like structures on laser plant PLD-400 with the use of an excimer transmitter is described. Through the method of ellipsometry there is investigated a growth rate and peculiarities of thickness distribution under different conditions of precipitation.
Comparative analysis of physical stress-strain properties of materials of additive production with common methods of casting as possibility to use 3D-printing in repair works on board ship in voyage under Arctic conditions
Authors: Dektyarev Alexandr , Tovpinets Alexandr , Grishin Pavel , Leitsin Vladimir , Morozov Vladimir
Published: January 2020

In the paper presented there is shown an analysis of temperature dependences of physical stress-strain characteristics of most spread thermo-plastic materials used as “ink” in 3D-printing: ABS, SBS, PLA, HIPS and PETG-plastics. The materials were tested in three cases: at room temperature +22ºC and at lower temperatures: 0ºC and - 40ºC. As an investigation of physical stress-strain characteristics there were carried out bending tests and tension tests.
Tópicos Ensino de Biblioteconomia VII
Authors: PALETTA FRANCISCO CARLOS , Modesto Fernando
Published: January 2020

Este livro dá prosseguimento ao esforço de um coletivo de professores de Biblioteconomia no sentido de contribuir com a área, por meio do caminho do ensino e da formação profissional de bibliotecários. Neste segundo volume os professores do (agora renomeado) Departamento de Informação e Cultura da Escola de Comunicações e Artes, compartilharem aspectos dos conteúdos ministrados em disciplinas do curso de graduação. É sabido, que a velocidade das mudanças tecnológicas influi nas mudanças sociais e econômicas, e requerem constante adaptação dos bibliotecários no desempenho de suas atividades em um mercado de trabalho que requer bom preparo formativo dos profissionais. Assim, a formação e a atualização do bibliotecário precisa ser percebido como uma maneira que permita adentrar a área profissional com segurança, bem como, dotado da consciência em buscar seu próprio desenvolvimento profissional contínuo apoiada nas competências transmitidas durante o curso de graduação. Os conteúdos apresentados estão divididos em linhas disciplinares adotadas pelo curso de biblioteconomia até 2017, e cobrem tópicos inerentes a formação e a prática profissional. Por seu lado, os textos não esgotam os temas tratados. Aliás, a intenção dos organizadores desta série é o de constituir uma obra aberta e contínua, e que deve incluir tópicos atualizados e inerentes aos cursos de biblioteconomia. Os tópicos relacionados, neste livro, foram estabelecidos segundo os critérios dos seus autores que detém ampla liberdade de escolha e de enfoque sobre o que consideram de interesse no instante da concepção do livro.
Fault-Diagnosing DCN-SLAM for 3D Change Object Detection: A Method based on Masking Input Images
Authors: tanaka kanji
Published: January 2020

Although image change detection (ICD) methods provide good detection accuracy for many scenarios, most of the existing methods rely on place-specific background modeling. The time/space cost for such place-specific models becomes prohibitive for large-scale scenarios, such as long-term robotic visual simultaneous localization and mapping (SLAM). Therefore, we propose a novel ICD framework that is specifically tailored for long-term SLAM. This study is inspired by the multi-map-based SLAM framework, where N multiple localizers are capable of mutual diagnosis, thus not requiring any explicit background modeling/model. We extend this multi-map diagnosis approach toward a more generic single-map-based object-level diagnosis framework (i.e., ICD), where state-of-the-art self-localization systems can be used in their original form, which is as the change object indicator. The available single localizer is extended to different N localizers by introducing different N masked input images. Further, we also consider map diagnosis on a state-of-the-art deep-visual-SLAM system (rather than on conventional bag-of-words or landmark -based systems) in which the blackbox nature of the deep convolutional neural network (DCN) complicates the diagnosis problem. We also consider a 3D point cloud (PC) -based SLAM, and for the first time (to the best of our knowledge) adopt the state-of-the-art scan context PC descriptor for the purpose of map diagnosis.
Implikasi Kebijakan Otonomi Daerah Indonesia
Authors: Madani Muhlis
Published: January 2020

Undang-Undang Nomor 22 Tahun 1999 yang telah diubah dengan undang-undang Nomor 32 Tahun 2004 berimplikasi terhadap model penyelenggaraan pemerintahan dari structural efficiency model menjadi local democracy model.
Analisis Krisis Tersembunyi dalam Implementasi Pembangunan dan Pemerintah daerah
Authors: Madani Muhlis
Published: January 2020

Penerapan otonomi daaerah sejak berlakunya sistem pemerintahan yang otonom masih dijumpai adanya berbagai krisis dalam hal implementasi desentralisasi pembangunan pemerintahan daerah.
Dimensi Interaksi Aktor Dalam Proses Perumusan Kebijakan Publik
Authors: Madani Muhlis
Published: January 2020

Madani, M. (2011). Dimensi interaksi aktor dalam proses perumusan kebijakan publik. Graha Ilmu.
ANALISA PRODUKTIVITAS DENGAN MENGGUNAKAN METODE MARVIN E. MUNDEL DALAM MENENTUKAN PRODUKTIVITAS PADA USAHA MINUMAN THAI TEA HAUSQ DI MAKASSAR
Authors: Andrie
Published: January 2020

Dalam upaya peningkatan produktivitas sebuah usaha, tahapan awal yang dilakukan dengan mengukur produktivitasnya. Tujuan dari penelitian ini untuk menganalisis pengukuran produktivitas parsial dan produktivitas total. Penelitian ini menggunakan pendekatan kualitatif dan bersifat deskriptif. Penelitian dilakukan pada usaha minuman Thai Tea HausQ dengan menentukan nilai output dan input. Nilai output dan input yang telah didapatkan selanjutnya dilakukan analisa dengan menghitung produktivitas parsial dan produktivitas total. Metode Marvin E. Mundel yang dilakukan dengan cara membagi jumlah output dengan masing-masing input.; Hasil pengukuran produktivitas untuk indeks produktivitas tenaga kerja meningkat sebesar 13%, indeks produktivitas beban listrik meningkat 11%, indeks produktivitas transportasi meningkat 13%, indeks produktivitas biaya penyusutan menurun sebesar 8%, dan indeks produktivitas bahan baku menurun sebesar 9%. Untuk pengukuran produktivitas total meningkat sebesar 12 %. Dari hasil pengukuran produktivas yang mengindikasikan bahwa usaha Thai Tea HausQ sudah berjalan efektif dan efisien.
Introducing the Media Use Behaviour Conceptual Framework
Authors: Parry Douglas , le Roux Daniel B.
Published: January 2020

In an increasingly digitally connected world researchers have sought to understand behaviour associated with digital communications media. We argue that a more consistent conceptualisation of media use behaviour and its etiological foundations is a necessary basis for research in this regard to progress. To this end, through the adoption of an affordances approach, we propose the Media Use Behaviour Conceptual Framework to describe the reciprocal relations between users (described in relation to personal characteristics and cognitive factors), the situations (consisting of social, physical, and technological dimensions) in which they use media, their media use behaviour, and the outcomes (both realised and expected) of this behaviour. This framework seeks to integrate the behaviourist and cognitivist approaches to action and, additionally, acknowledges the socially constructed and deterministic role of media in action. It is argued that such a framework will provide a useful basis upon which researchers can consider various individual differences in observed media use behaviours and associated outcomes and, importantly, understand why particular media use behaviours occur.
The Impact of Climate Change on Risk and Return in Indian Agriculture
Authors: Costa Francisco J M , Forge Fabien , Garred Jason , Pessoa João Paulo
Published: January 2020

We investigate the extent to which climate change will result in insurable and uninsurable losses for farmers in India. Changes in temperature and precipitation patterns may increase the volatility of farmers' yields, leading to rising but insurable risk. These changes may also reduce the expected yield in an `average year', causing uninsurable reductions in the returns to farming. We use a multi-run climate model to predict the future distribution of potential yields at the district level for sixteen major crops. For the average district, we project a sharp decline in expected agricultural revenue, but small shifts in volatility. This is because weather draws resulting in extremely low agricultural returns -- what had once been 1-in-100-year events -- are predicted to become the norm by the end of the century. Our projections therefore imply substantial uninsurable losses from the changing climate for Indian farmers.
The Effects of Self-Guided Meditation and Napping on Memory Consolidation in Humans
Authors: Dastgheib Mohammad
Published: January 2020

Master's thesisNumerous studies have reported that, compared to an equivalent period of wakefulness,post-training sleep (overnight or daytime naps) benefits memory consolidation (Diekelmann & Born, 2010; Mednick, Nakayama, & Stickgold, 2003; Plihal & Born, 1999; Walker et al.,2003). However, most investigations have employed various forms of “active wakefulness” (e.g., sensorimotor and cognitive tasks) as a comparison condition for sleep, while few studies have examined the role of “quiet wakefulness” in memory consolidation, even though some of the EEG oscillations during quiet waking resemble those present in sleep (e.g., increased activity in the theta-alpha range) (Brokaw et al., 2016). This study aimed to examine the consolidation of declarative (word-pair associates) andnon-declarative (marble maze visuo-motor task) learning over a 60-minutes time interval (with continuous EEG monitoring) filled with either (A) napping; (B) active-waking (watchinga video); or (C) quiet-waking (self-guided meditation).The results of the current study suggested that memory consolidation may not be a sleepspecific-phenomenon. In fact, mindfulness meditation appeared to be more advantageous than a short nap for the consolidation of declarative memories. This study also found that SWSexerts significant effects on the retention of non-declarative memory. For nappers, the absence of SWS resulted in noticeable performance enhancements compared to participants who entered SWS. Thus, it is possible that SWS plays a disadvantageous role in the consolidationof procedural memory. It is thought that sleep inertia caused by SWS is partly responsible for the impairments in tasks procedural memory. The findings of current study contribute to the understanding of memory consolidation and provide insights about the role of waking states for future studies.
Impact of Automated Teller Machine (ATM) Service Quality on Customer Satisfaction in the Nepalese Commercial Banks
Authors: Joshi Chhemanand
Published: January 2020

The aim of this study was to understand the impact of ATM service quality on the customer satisfaction in Nepalese banking sector. This study has used the primary data of customer satisfaction survey (N = 60). The data was collected using a structured questionnaire designed to ascertain the satisfaction levels. Descriptive statistics analysis was used to explain the satisfaction level of respondents. Correlations and multiple linear regression analysis were used to test the hypothesis. The ATM services have positive impact on the customer satisfaction; if proper functioning is ensured by the banks, there will be significantly higher customer satisfaction. Availability of cash has highest impact on customer satisfaction. Next most influencing factor is location of ATM. The study has been carried out primarily in Dhangadhi, Kailali and hence cannot be generalized on all over Nepal. The banks can utilize the finding to improve the services of ATMs and can enhance the overall satisfaction of their customers. The paper has identified, availability of cash as the most influencing significant factor, which the banks may take care to enhance the customer satisfaction.
Sustainable Tourism Appliance in Destinations: An Overview of Ghodaghodi Lake Area in Far West Nepal
Authors: Upadhayaya Pranil Kumar
Published: January 2020

Tourism is like a two edge sword which has both positive and negative consequences. Such a drift of tourism is found applicable in all destinations big or small, old or new. Nevertheless, the development intervention of new destinations with the sustainable tourism maxim from the very beginning can be much rewarding than a mass tourism induced mature destinations. Ghodaghodi Lake Area (GLA), a new tourist destination in Ghodaghodi Municipality (GM) of Kailali, extending to 2,726 hector of wetland with its designation as a Ramasar site, constitutes immense potential for prosperity through the sustainable tourism operation and management from its existing tourism offerings like lake viewing hiking, trekking, bird watching, and religious tourism activities. In this context, this paper aims to shed light on how a new destination like GLA is embedded with a number of challenges for sustainable tourism issues and what can be its remedy from sustainable tourism perspective. Developed through mix methods (qualitative and quantitative) of research, this paper has embedded its findings with the four progressive theoretical models (advocacy, cautionary, adaptability, and knowledge based platforms) as sustainable tourism. The poorly equipped infrastructures, lack of planned development activities, meager institutional capacity, and inadequate marketing have been pointed out as the drawback. This paper recommends that the formulation of a holistic plan of actions in the form of tourism master plan consisting of a self sustaining revenue model and its sincere application is the bottom-line to address sustainable tourism appliance challenges.
A Case Report of Cerebral Vasospasm Following Elective Clipping of Unruptured Aneurysm: Pathogenetic Theories and Clinical Features of a Dangerous Underestimated Event
Authors: Fiaschi Pietro , Pasquale Anania , Marco Ceraudo , Alessandro D’Andrea , Fiaschi Pietro , Alessandro Prior , Monica Truffelli , Gianluigi Zona
Published: January 2020

Background and Importance: Angiographic-proven and clinically-evident cerebral vasospasm (CVS)
after uneventful elective clipping of unruptured intracranial aneurysm (UIA) is a very rare and often
underestimated event. To date, the knowledge of risk factors, pathophysiology, and demographic
characteristics of these conditions are solely relegated to few case reports. With the aim of better characterize
shared features and mechanism that could be involved in such event we also performed a review of the
present literature and analyzed aneurysm’s features, surgical factors, treatments, recovery and of all reported
cases of CVS after elective clipping.
Clinical Presentation: We report a case of a cerebral vasospasm following elective clipping of a middle
cerebral artery (MCA) bifurcation aneurysm in a 59-year-old woman who smoked next days after treatment,
despite medical advice. We found ten cases comparable to ours with angiographic-proven and clinically
evident cerebral vasospasm after uneventful elective clipping.
Conclusion: Classic mechanisms of CVS following SAH have been widely studied. In all the cases we
analyzed, no subarachnoid bleeding occurred, as demonstrated in pre and postoperative CT scans and
intraoperatively. Various theories on the possible mechanism have been advanced. It seems reasonable that
CVS following elective clipping of unruptured aneurysm is a multifactorial phenomenon. Although its
pathogenesis is unclear, clinicians should keep in mind the existence of this event, that is rare, but it could
be seen in the clinical practice of every neurosurgery ward. In our opinion, it’s worth to know this possible
post-operative complication because, when suspected clinical signs and symptoms of delayed ischemic
neurological deficit (DIND) arise after elective clipping, it’s important to make an early diagnosis of CVS
owing to early treatments are critical to improve clinical outcome
Keluarga Sakinah dalam Perspektif Ulama Tafsir: Studi Terhadap Rumah Tangga Nabi Adam
Authors: Miswanto Agus
Published: January 2020

The large number of divorces that occur in Indonesia is due to the failure of the establishment of a Sakinah family so that it is a very fundamental case in Islamic law. Therefore, the purpose of this study is to reveal the values ​​of the sakinah family placed by the Prophet Adam and Eve. This study uses a descriptive literature study using content analysis methods and comparative approaches. QS. Al-Baqarah verses 35-37 become the main object with the focus of the study on four interpretations, namely al-Baghawi, Ibn Kathir, al-Alusi, and al-Maraghi. This research found that 1) family life is a nature from the time of Azali; 2) sakinah family can be realized with equality in a love relationship, fulfillment of basic household needs, obedience to sharia rules; 3) sakinah life can be damaged due to violations of Sharia rules and third party intervention; and 4) the destruction of sakinah life can be fixed with each party having an awareness of the mistakes that have been made and then repenting to Allah SWT
Filantropi Kreatif: Pemberdayaan Ekonomi Umat Berbasis Zakat Produktif pada Program 1000 UMKM Lazismu Kabupaten Pekalongan
Authors: Kholidah Nur , Salma Ayesha Nur
Published: January 2020

This study aims to find out how the mechanism, impact, supporting factors, and obstacles in implementing the community empowerment based on productive zakat in 1000 MSME’s programs. This research is field research using a descriptive qualitative approach. The subject of this research was Lazismu management and the mustahik. This study found that the 1000 MSME’s program was instrumental in helping MSME’s who had difficulty in developing their businesses. The assistance process is important in the success of the empowerment program. The impact of this program is an increase in business results, family income, abilities, knowledge, and skills as well as increased religious knowledge. Supporting factors for this program include the collaboration with Aisiyah institutions to provide assistance to the mustahik. While the constraints faced are not yet optimal implementation of SOPs and the lack of reporting and documentation of 1000 MSME programs
Tinjauan Filosofis Terhadap Undang-undang Nomor 23 Tahun 2011 Tentang Pengelolaan Zakat
Authors: Abdoeh Nor Mohammad
Published: January 2020

Zakat is an Islamic teaching that aims to realize the welfare of society. Islam wants and hopes for an equitable distribution of income, so wealth does not only revolve around a particular group. Indonesia as the largest Muslim majority country in the world has serious attention to the management of zakat funds. This is evidenced by the enactment of Regulation No. 23 of 2011 on the management of zakat. The purpose of this paper is to determine the nature and substance of the regulation. This research with a philosophical approach that is by explaining the nature and wisdom of the formal object. The result shows that the essence of this rule is none other than to accommodate the Muzakki and Mustahiq for the welfare of society
Le poste d’urgence médicopsychologique téléphonique : un nouvel outil dans la prise en charge du trauma par les CUMP
Authors: Abgrall G. , Neff E. , Deloche-Gaudez F. , Akhounak S.
Published: January 2020

Les cellules d’urgence médicopsychologique (CUMP) ont été créées en 1995 pour prendre en charge les traumatismes psychiques résultant d’événements collectifs. Leurs interventions, au plus près de l’événement, visent à contenir les réactions émotionnelles immédiates des personnes impactées et à favoriser un premier récit de ce qu’elles ont vécu afin de limiter l’installation de troubles de stress post-traumatique. Depuis leur création, les CUMP n’ont cessé d’améliorer leur organisation et leurs outils pour répondre aux besoins des blessés psychiques. Alors que des entretiens par téléphone n’étaient pas prévus initialement, la CUMP de Paris a recouru à cet outil à la suite du tsunami de 2004 et des attentats de 2015. Ces entretiens téléphoniques sont apparus comme un moyen précieux d’inclure dans les dispositifs de soins les victimes qui ne pouvaient se rendre, en raison de leur éloignement géographique ou de leurs symptômes, aux postes d’urgence médicopsychologique (PUMP) mis en place. Désormais, l’outil téléphonique est régulièrement utilisé dans le cadre de PUMP téléphoniques qui complètent utilement les dispositifs sur le terrain. Fort de ce constat, le ministère de la Santé a récemment acté la création d’un « PUMP téléphonique national » et en a confié la responsabilité à la CUMP de Paris. Il peut être activé en cas de situation sanitaire exceptionnelle sur le territoire français ou à l’étranger si des ressortissants français étaient impliqués. Son ouverture à deux reprises, en 2018, lors du séisme de Lombok et de l’attentat de Strasbourg, a montré toute la pertinence du nouvel outil téléphonique dans des situations pourtant très différentes.
Protective Effect of Boswellic Resin Against Memory Loss and Alzheimer’s Induced by Aluminum Tetrachloride and D-Galactose (Experimental study in Mice)
Authors: Zerrouki K. , Djebli N. , Gadouche L. , Orhan I. Erdogan , Deniz F. SezerSenol , Erdem S. Aslan
Published: January 2020

Nowadays, because of the industrialization, a lot of contaminant were available ; the consequences of this availability are apparition of diseases including neurodegeneration. Neurodegenerative diseases of the human brain comprise a variety of disorders that affect an increasing percentage of the population. This study is based on the effect of the Boswellic resin, which is from a medicinal plant and known for its antioxidant effects on nerve cell damage. The objective of this work was to evaluate the in vitro and in vivo effects of the Boswellic resin on anticholinesterase activity and Alzheimer’s disease (AD) induced by D-galactose and aluminum tetrachloride in Swiss mice. Chemical composition of the resin essential oil was identified by the CG-MS analysis. The antioxidant activity was also assessed by the DMPD and metal chelation methods. In order to understand the mechanism of memory improvement, the acetylcholinesterase, AChE, and butyrylcholinesterase, BChE, inhibitory assays were performed. In vivo part of the study was achieved on Swiss mice divided into four groups: control, AD model, treated AD, and treated control group. The identification of chemical composition by CG-MS reach the 89.67% of the total extract compounds presented some very important molecules (p-Cymene, n-Octyl acetate, α-Pinene…). The present study proves that Boswellic resin improves memory and learning in treated Alzheimer’s group, modulates the oxidative stress and be involved in the protective effect against amyloid deposition and neurodegeneration, and stimulates the immune system in mice’s brain.
Évaluation des activités antioxydante et antibactérienne des extraits aqueux des feuilles et des fleurs deBituminaria bituminosa(L.) Stirton
Authors: Bammou M. , Bouhlali E.D.T. , Sellam K. , El-Rhaffari L. , Ibijbijen J. , Nassiri L.
Published: January 2020

L’objectif de ce travail était d’évaluer le pouvoir antioxydant et l’activité antibactérienne des extraits aqueux (EA) des feuilles et des fleurs deBituminaria bituminosa(L.). Les résultats révèlent qu’aussi bien les feuilles que les fleurs contiennent des teneurs élevées en phénols totaux estimées respectivement à 141,4 ± 1,43 mg équivalent d’acide caféique (EAC)/g d’extrait et 128,11 ± 3,00 mg EAC/g d’extrait. Par ailleurs, le test deferric reducing antioxidant powermontre que le pouvoir réducteur de l’EA des feuilles est plus élevé (64,27 ± 2,97 mg ET/g d’extrait) que celui des fleurs (53,61 ± 3,81 mg ET/g d’extrait). La capacité de piégeage du radical libre DPPH (1,1-diphényl-2-picrylhydrazyl) est très intéressante avec une CI50 égale à 0,203 ± 0,002 mg/ml pour l’EA des feuilles et à 0,457 ± 0,003 mg/ml pour l’EA des fleurs. En outre, les deux extraits testés présentent une activité protectrice antiradicalaire traduite par un temps de demi-hémolyse important, de 133,61 ± 1,22 et 103,45 ± 6,63 minutes respectivement pour les feuilles et les fleurs. Quant aux essais d’activité antimicrobienne, l’EA des feuilles s’est avéré plus efficace que celui des fleurs, il montre une activité remarquable sur toutes les souches étudiées. L’effet de cet extrait est notable vis-à-visBacillus subtilisavec un maximum d’inhibition de l’ordre de 13,33 ± 0,57 mm.
Rate-controlled intraventricular endoscopic irrigation via bipolar foot pedal activation: technical note
Authors: Hoshide Reid , Rennert Robert C. , Sanchez Carlos E. , Martin Joel R. , Cheung Vincent J. , Gyles Gayle , Levy Michael L.
Published: January 2020

Irrigation during intraventricular endoscopic surgery is critical for visualization, with normal intracranial pressure maintained by balancing fluid ingress and egress. Although irrigation is typically achieved through manual manipulation of inexact stopcocks, the authors have developed a rate-controlled, foot pedal–activated system for precise intraventricular irrigation by using a standard irrigating bipolar electrocautery machine.

This study is a retrospective review of patients who underwent endoscopic intraventricular surgery between January 1, 2018, and September 25, 2019, in which this irrigation system was used. Important components of this system include a bipolar module irrigation regulator that is set to a desired rate, a secure connection of the bipolar irrigation tubing to the endoscope, and one or more open egress ports on the endoscope for passive fluid drainage. Nineteen consecutive patients were identified on review (average age ± SD, 4.3 ± 4.1 years). Procedures performed included third ventriculostomies (n = 10); arachnoid/choroid cyst fenestrations/resections (n = 3); biopsy/tumor resection (n = 1); and combined procedures (n = 5). Foot pedal–controlled irrigation provided visualization of all intraventricular structures. A single operator was able to control the endoscope, endoscopic instruments, and irrigation, with assistance as indicated for more complex maneuvers. There were no perioperative complications. Because this setup is easily constructed from a standard irrigating bipolar machine, delivers precise irrigation flow rates, and facilitates a single-surgeon bimanual technique, these data support the utility of foot-controlled irrigation for endoscopic intraventricular surgery.
Prognostic factors for spinal chordomas and chondrosarcomas treated with postoperative pencil-beam scanning proton therapy: a large, single-institution experience
Authors: Murray Fritz R. , Snider James W. , Schneider Ralf A. , Walser Marc , Bolsi Alessandra , Pica Alessia , Lomax Antony J. , Weber Damien C.
Published: January 2020

OBJECTIVE

The aim of this paper was to evaluate the prognostic factors in surgical and adjuvant care for spinal chordomas and chondrosarcomas after surgery followed by high-dose pencil-beam scanning proton therapy (PBS-PT).

METHODS

From 1997 to 2016, 155 patients (61 female patients; median age 55 years) with spinal (cervical, n = 61; thoracic, n = 29; lumbar, n = 13; sacral, n = 46; pelvic, n = 6) classic chordomas (n = 116) and chondrosarcomas (n = 39; most were low grade) were treated with maximal safe resection followed by PBS-PT (median dose prescribed: 74 Gy [relative biological effectiveness], range 48.6–77 Gy). The majority of patients (n = 153, 98.7%) had undergone at least 1 resection prior to PBS-PT (median 1, range 0–5; biopsy only, n = 2). Fewer than half (45.1%) of the surgeries were rated as gross-total resections (GTRs) prior to PBS-PT. Surgical stabilization (SS) was present in 39% of all patients (n = 60). Ninety-one patients (59%) presented with macroscopic tumor at the start of PBS-PT. The median follow-up duration was 64.7 months (range 12.2–204.8 months).

RESULTS

The 5-year local tumor control, disease-free survival (DFS), and overall survival were 64.9% (95% CI 56.3%–73.5%), 59.4% (95% CI 50.6%–68.2%), and 77.9% (95% CI 70.6%–85.2%), respectively. In total, 63 patients (40.6%) experienced failure during the follow-up period: local only in 32 (20.6%), distal only in 7 (4.5%), local + distal in 19 (12.3%), surgical pathway failure (SPF) only in 2 (1.3%), local + SPF in 2 (1.3%), and distal + SPF in 1 (< 1%). Univariate analysis identified gross residual disease, the presence of SS, and treatment era prior to 2008 as highly significant for worse outcome, with all 3 remaining significant on multivariate analysis. The type of surgery (GTR or subtotal resection/biopsy) and whether GTR was achieved by en bloc or curettage did not show a significant prognostic effect. Surgical complications prior to PBS-PT were present in 42.5% of all surgically treated patients and were seen more commonly in patients with multiple surgical interventions (p = 0.005) and those operated on with the intent of en bloc resection (p = 0.006).

CONCLUSIONS

The extent of resection and metallic stabilization substantially influenced clinical outcomes for patients with spinal chordoma or chondrosarcoma despite high-dose adjuvant PBS-PT. Optimal upfront surgical management of these tumors continues to include GTR, as possible, with prompt adjuvant proton therapy.
Differences and characteristics of symptoms by tumor location, size, and degree of spinal cord compression: a retrospective study on 53 surgically treated, symptomatic spinal meningiomas
Authors: Yamaguchi Satoshi , Menezes Arnold H. , Shimizu Kiyoharu , Woodroffe Royce W. , Helland Logan C. , Hitchon Patrick W. , Howard Matthew A.
Published: January 2020

OBJECTIVE

The differences in symptoms of spinal meningiomas have rarely been discussed from the perspective of tumor characteristics. The main purpose of this paper was to define the differences, if any, in symptoms in patients with spinal meningiomas with respect to tumor size, location, and degree of spinal cord compression. The authors also sought the threshold of spinal cord compression that causes motor weakness.

METHODS

The authors conducted a retrospective study of 53 cases of spinal meningiomas that were surgically treated from 2013 to 2018. Symptoms related to the tumor were classified as motor weakness, sensory disturbance, pain, and bowel/bladder dysfunction. Based on MR images, tumor location was classified by spinal level and by its attachment to the dura mater. Tumor dimensions were also measured. Occupation ratios of the tumors to the spinal canal and degree of spinal cord flattening were sought from the axial MR images that showed the highest degree of spinal cord compression.

RESULTS

Motor weakness and sensory disturbance were significantly more common in thoracic spine meningiomas than in cervical spine meningiomas (p < 0.001 and p = 0.013, respectively), while pain was more common in meningiomas at the craniovertebral junction (p < 0.001). The attachment, height, width, depth, and volume of the tumor showed no significant difference irrespective of the presence or absence of each symptom. In cases of motor weakness and sensory disturbance, occupation ratios and spinal cord flattening ratios were significantly larger. However, these ratios were significantly smaller in the presence of pain. Multivariate logistic regression analysis revealed that occupation ratio independently contributed to motor weakness (OR 1.14, p = 0.035) and pain (OR 0.925, p = 0.034). Receiver operating characteristic curve analysis suggested that occupation ratio with a value of 63.678% is the threshold for the tumor to cause motor weakness.

CONCLUSIONS

The study showed the difference in clinical presentation of spinal meningiomas by spinal level, occupation ratio, and spinal cord flattening ratio. An occupation ratio of approximately 64% could be utilized as the threshold value of tumor growth to cause motor weakness. Tumor growth in the cervical spine might cause pain symptoms before causing motor weakness. The relationship between the tumor and its symptomatology should be discussed with respect to tumor size relative to the surrounding spinal canal.
Pengaruh Bauran Pemasaran Pada Penjualan Cerutu PT BIN Di Indonesia
Authors: Musaiyadi
Published: January 2020

This paper aim to analyze how so far the effect of marketing mix toward total sale of BIN’s cigars in local market. By using mountly data from 2016.1 to 2018.12 on error correction model, this research finds out: (1) product varian of BIN’s cigars significant statistically influence total sale of BINs cigars in local market positively. (2) average price of BIN’s cigars statistically influences total sales of BIN’s cigars in local market negatively. (3) promotion costs of BIN’s cigars statistically did’nt influences total sales of BIN’s cigars in local market negatively. (4) distribution channels of BIN’s cigars statistically did’nt influences total sales of BIN’s cigars in local market negatively. (5) All of those independent variables significant statistically and simultaneously influences total sales of BIN’s cigars in local market positively.
Pengaruh Shift Kerja, Stres Kerja Dan Lingkungan Kerja Terhadap Kinerja Karyawan Di PT. Liku Telaga Gresik
Authors: Yani Elviani Lestari  , Moh. Bukhori  , Fathorrahman
Published: January 2020

In determining and achieving a goal in a organization, one element that’s needed is human resource. In facing challenges to achieve organizational goals, continues improvement is needed to improve and enhance employee performance. The goals of this research is : 1. To know and analyze the impact of shift system to employee’s performance, 2. To know and analyze the impact of employee’s stress level to employee’s performance, 3. To know and analyze the impact of work environment to employee’s performance, 4. To know and analyze the impact of shift system, employee’s stress level, and work environment simultaneously to employee’s performance. This research is associative casual research using quantitative approach. This research was conducted on PT Liku Telaga’s employees. The population of this research is all permanent employees of PT Liku Telaga. Samples were taken using proportional random sampling method from 68 respondents. Those data were processed using SPSS software ver.20. The result of this research shows that 1. Shift system doesn’t affect significantly and affect positively to employee’s performance 2. Employee’s stress level affect significantly and affect negatively to employee’s performance 3. Work environment affect significantly and affect positively to employee’s performance 4. Shift system, employee’s stress level and work environment affect significantly to PT Liku Telaga employee’s performance.
Bitter melon fruit extract affects hepatic expression of the genes involved in inflammation and fatty acid metabolism in ob/ob mice
Authors: Rizqi Dwijayanti Dinia , Okuyama Tetsuya , Ishii Toshinari , Mukai Eri , Nishizawa Dr. Mikio
Published: January 2020

Background: The fruit of bitter melon (Momordica charantia L.) has traditionally been used as a crude drug to treat obesity and diabetes mellitus. Previously, we reported that an ethyl acetate (EtOAc)-soluble fraction of bitter melon fruit extract showed anti-inflammatory effects on interleukin-1β-treated rat hepatocytes. The liver plays a pivotal role to maintain homeostasis of glucose and lipid. It is speculated that the administration of an EtOAc-soluble fraction of a bitter melon fruit extract (BMFA) may change the expression profile of hepatic genes involved in inflammation, glucose metabolism, and lipid metabolism.Objective: We aimed to evaluate the effects of BMFA on the gene expression in the liver of ob/ob mice, which are deficient in leptin and are used as a diabetes mellitus model. The changes may be related to hepatic steatosis and obesity.Methods: Male 8-week-old ob/ob mice (average body weight, 40.9 g) were fed a standard diet with and without BMFA (ob/ob+BMFA and ob/ob–BMFA groups, respectively; 4 mice/group) for seven days. The livers were excised to prepare total RNA for microarray expression analyses. Signal ratios (i.e., ob/ob+BMFA versus ob/ob–BMFA group) were calculated to compare gene expression.Results: The mRNA levels of 2,632 genes were significantly changed in the livers of ob/ob+BMFA mice when compared with those of ob/ob–BMFA mice. As expected, proinflammatory cytokine and chemokine genes were significantly downregulated by BMFA. The acyl-Coenzyme A thioesterase 3 gene in fatty acid oxidation was upregulated in ob/ob+BMFA liver, whereas free fatty acid receptor 2 and solute carrier family 27 member 3 genes were downregulated. Most genes involved in glycolysis and gluconeogenesis were not affected by BMFA. In contrast, the level of peroxisome proliferator-activated receptor γ coactivator 1α mRNA significantly increased in ob/ob+BMFA mice, suggesting that BMFA administration may reduce insulin resistance in ob/ob mice.Conclusion: Our study suggested that BMFA may possess anti-inflammatory effects and enhance fatty acid metabolism in ob/ob mouse liver. These data imply the possibility that EtOAc-soluble constituents in bitter melon fruit may improve lipid accumulation in the liver during obesity and diabetes mellitus, as well as non-alcoholic fatty liver disease.Keywords: Momordica charantia, gene expression, inflammation, diabetes mellitus, non-alcoholic fatty liver disease.
Modulation of Gut-Brain Axis Improves Microbiome, Metabolism, and Mood
Authors: Talbott Shawn M , Talbott Julie A , Stephens Bret J , Oddou Marc P
Published: January 2020

Objective: There is a close bidirectional relationship between overweight/obesity and depression, which may be largely modified through the microbiome and the gut-brain axis. Previous research has shown targeted weight loss effects and anti-depressive benefits of diets high in fiber and phytonutrients and low in sugar and processed foods. Thus, our objective was to determine changes in parameters common to both obesity and depression (e.g., microbiome balance, metabolic biomarkers, and psychological mood state) following a coordinated supplementation regimen combining probiotics, prebiotics, and phytonutrients (“phytobiotics”).Methods: Thirty-three (33) healthy subjects participated in a 6-week supplementation trial (Amare “Project b3”) containing a targeted blend of probiotics, prebiotics, and phytobiotics. Microbiome balance was assessed in fecal samples using a novel PCR-based analysis (BiomeTracker) that has previously compared favorably to 16S sequencing. Biomarkers, including blood lipids, glucose, cortisol, and butyrate kinase, were assessed as indicators of effects on cardiovascular, inflammatory, and energy metabolism. Psychological mood state was assessed using the validated Profile of Mood States survey (POMS) to generate scores for Global Mood State and six sub-scales (Depression, Tension, Fatigue, Anger, Confusion, and Vigor).Results: Following supplementation, there was a significant increase in populations of “good” bacteria (+8% Bifidobacterium, +33% Lactobacillus, +62% S. Thermophilus, +90% Akkermansia) as well as bacterial ratios associated with a healthier “obesity-resistant” metabolism (+6% composite score, -11% Firmicutes, +6% Bacteroidetes, -14% F/B ratio). Metabolites associated with stress and glycemic control improved post-supplementation (-11% cortisol; +89% butyrate kinase, -6% glucose), as did body fat (-2%) and blood lipids (-8% total cholesterol, -5% LDL, +3% HDL, -23% triglycerides, -7% TC/HDL). Psychological indices were significantly improved post-supplementation for both positive (+17% Global Mood; +23% Vigor) and negative mood states (-38% Depression; -41% Tension; -42% Fatigue; -31% Confusion; -39% Anger).Conclusions: These results demonstrate the close relationship between microbiome balance, systemic metabolism, and psychological parameters – and the utility of targeted supplementation to optimize gut-brain-axis balance for both improved metabolism and enhanced mental wellness.Keywords: Obesity; Depression; Anxiety; Stress; Probiotics; Prebiotics; Diet; Supplement
Kistik fibrozis hastalığında tıbbi beslenme tedavisi
Authors: EDE Elif , KÖSEOĞLU Sabiha Zeynep Aydenk
Published: January 2020

Kistik fibrozis (KF), çocuklarda ve yetişkinlerde görülen, multisistem tutulum gösteren genetik bir hastalıktır. Yenidoğanlarda en sık Avrupa kökeninde görülmekle bilrikte farklı etnik kökenlerde hastalığın görülme sıklığı 1/3500 ila 1/30000 arasında değişmektedir. KF hastalığında beklenen yaşam süresinin uzatılması ve sağ kalım oranının artırılması için tanının erken konulması, tedaviye erken başlanması gerekmektedir. KF’de sindirim yetersizliği dolayısıyla enerjinin etkili olarak kullanılmaması, enerji ihtiyacının artması, gastrointestinal problemler ve iştah azalmasına bağlı olarak yetersiz beslenme; malabsorbsiyon kaynaklı olarak da vitamin mineral yetersizlikleri yaygın olarak görülmektedir. Beslenme gereksinimlerinin artmasına karşın ihtiyacın karşılanamamasından dolayı KF’li bebek ve çocuklarda malnutrisyon görülmektir. Bu derlemede Kistik Fibrozis hastalığında tıbbi beslenme tedavisi ilkelerinin ve beslenme tedavisinin öneminin ortaya konması amaçlanmıştır.
Food frontiers: Insects as food, is the future already here?
Authors: Marcucci Caterina
Published: January 2020

Nowadays the current global food model is becoming unsustainable mainly due to the world human population exponential growth and the consequent overexploitation of natural resources used for agriculture and livestock. Therefore, an urgent rethinking of the relationship we have with food resources is needed.

Since 2008, FAO has indicated edible insects as food of the future, capable of contributing through its use to the resolution of problems relating to the current global model of food consumption.

The use of insects as food and feed on a global scale has health, environmental, economic and social benefits because they have characteristics that make them nutritious, accessible and reared with low environmental impact.

From the entry into force in 2018 of the EU regulation n. 2283/2015 concerning novel foods, edible insects have gone from being a probable food of the future to already being part of the present in European countries.

Currently there are numerous companies that produce insect-based foods for distribution on the market and entrepreneurial realities and professional figures involved in this trade multiply exponentially.

Thus, Westerners will have to begin to familiarize themselves with the idea of insects in general, breaking down prejudices and therefore also undermine the food taboo.
АПРОКСИМАЦІЯ ПІДГОТОВКИ УКРАЇНСЬКИХ ПРИКОРДОННИКІВ ДО ЗАГАЛЬНОЄВРОПЕЙСЬКИХ ОСВІТНІХ СТАНДАРТІВ
Authors: Балендр Андрій
Published: January 2020

У статті здійснено порівняльний аналіз впровадження галузевої рамки кваліфікацій для підготовки прикордонників національними прикордонними відомствами країн Європейського Союзу (ЄС) та України з метою подальшого впровадження набутого досвіду в систему професійної підготовки персоналу Державної прикордонної служби України. Визначено, що підготовка прикордонників в країнах ЄС відбувається відповідно до загальноєвропейських уніфікованих стандартів, основними з яких вважаються уніфіковані програми підготовки та Галузева рамка кваліфікацій сфери охорони кордонів країн ЄС. Висвітлено організацію перевірки валідності кваліфікаційної рамки національними експертами, які здійснили опис процесу перевірки валідності, зазначивши: використану методику, яким чином проводилась консультаційна робота, організаційну репрезентативність. Експерти використовували такі методи: роботу у складі робочої групи, надання письмових консультацій, проведення інтерв’ю з відповідним персоналом сфери охорони кордону, а також фахівців з підготовки, перевірку та порівняння існуючих профілів компетентностей та професійних стандартів відповідних прикордонних відомств, перевірку та порівняння з існуючими навчальними програмами.У рамках цього дослідження автором було узагальнено отримані результати роботи національних експертів прикордонних відомств і результати аналізу профілів компетентностей і результатів навчання галузевої рамки кваліфікацій та їх порівняння з професійними функціями прикордонників у країнах ЄС та України. Автором було проведено аналіз можливості використання цього досвіду з метою його впровадження в систему професійної підготовки персоналу прикордонного відомства України.
ФОРМУВАННЯ ЕКОНОМІЧНОЇ КОМПЕТЕНТНОСТІ МАЙБУТНІХ КВАЛІФІКОВАНИХ РОБІТНИКІВ МАШИНОБУДІВНОГО ПРОФІЛЮ ЗАСОБАМИ ХМАРНИХ ТЕХНОЛОГІЙ
Authors: Сікорака Ліна
Published: January 2020

Обґрунтовано необхідність формування економічної компетентності кваліфікованих робітників машинобудівного профілю. Акцентовано увагу на тому, що сучасна модель професійної підготовка майбутніх кваліфікованих робітників має базуватися на інноваціях, які мають забезпечувати формування економічної компетентності.Одним із шляхів удосконалення навчального процесу в закладі професійної (професійно-технічної) освіти є використання “інноваційних педагогічних технології”, які засновані на візуалізації навчального матеріалу засобами хмарних технологій. Аналіз останніх досліджень і публікацій показав, що проблемі формування економічної компетентності майбутніх кваліфікованих робітників машинобудівного профілю в закладах професійної освіти не приділено належної уваги. Особливо не вистачає розробленого навчально-методичного забезпечення з економічних предметів з використанням хмарних сервісів. Метою дослідження є здійснення теоретико-методологічного аналізу хмарних технологій, як засобу формування економічної компетентності майбутніх кваліфікованих робітників машинобудівного профілю.Аргументовано, що економічне виховання та економічна підготовка формує економічне мислення, розвиває економічну свідомість і тим самим формує економічну культуру і компетентність. Визначено, що формування економічної компетентності учнів закладів професійної освіти відбувається переважно авторськими електронними навчальними матеріалами (інтерактивні плакати, презентації, відео матеріали), які розробляються викладачами самостійно. Розглянуто види хмарних технологій та сервісів. Визначено, що застосування хмарних технології в навчальному процесі є стратегічно та економічно вигідним, дає можливості швидко оновлювати інформаційний матеріал, забезпечує гнучкий спосіб задоволення освітніх потреб учнів. На конкретних прикладах відображено використання хмарних технологій на різних етапах уроку “Основи галузевої економіки та підприємництва”. Зроблено висновок, що формування економічної компетентності за допомогою хмарних технологій дозволяє вирішити цілий ряд педагогічних завдань: забезпечити інтенсифікацію навчання, активізацію навчальної та пізнавальної діяльності, формування і розвиток критичного і візуального мислення, підвищення економічної грамотності та культури тощо.