bluuebunny/crossref_metadata_2025 huggingface dataset:
Safety evaluation of PEGylated MNPs and p-PEGylated MNPs in SD rats
Authors: Wen Hairuo , Huo Guitao , Qin Chao , Wu Hui , Wang Dan , Dan Mo , Geng Xingchao , Liu Shujie
Published: December 2023

Polyethylene glycol-coated magnetic nanoparticles (PEGylated MNPs) have demonstrated prominent advantages in cancer diagnosis and hyperthermia therapy. However, there is currently lack of standard mode and sufficient toxicity data for determining the delayed risk of PEGylated MNPs. Nevertheless, the toxicity potentials, especially those associated with the oxidative stress, were ubiquitously reported. In this study, PEGylated MNPs and p-PEGylated MNPs were administrated to SD (Sprague Dawley) rats by single intravenously injection, and various toxicity indicators were monitored till 56 days post-administration for a comprehensive toxicity evaluation. We revealed that both nanoparticles could be rapidly cleared from plasma and enter tissues, such as, liver, kidneys and spleen, and p-PEGylated MNP is less prone to be accumulated in the tissues, indicating a lower toxicity risk. PEGylated MNPs were more likely to up-regulate the expression levels of Th2 type cytokines and trigger inflammatory pathways, but no related pathological change was found. Both MNPs are not mutagenic, while recoverable mild DNA damage associated with the presence of nanoparticles might also be observed. This study demonstrated a research approach for the non-clinical safety evaluation of nanoparticles. It also provided comprehensive valuable safety data for PEGylated and p-PEGylated MNPs, for promoting the clinical application and bio-medical translation of such MNPs with PEG modifications in the cancer diagnosis and therapy.
The generation of detergent-insoluble clipped fragments from an ERAD substrate in mammalian cells
Authors: Daskivich Grant J. , Brodsky Jeffrey L.
Published: December 2023

Proteostasis ensures the proper synthesis, folding, and trafficking of proteins and is required for cellular and organellar homeostasis. This network also oversees protein quality control within the cell and prevents accumulation of aberrant proteins, which can lead to cellular dysfunction and disease. For example, protein aggregates irreversibly disrupt proteostasis and can exert gain-of-function toxic effects. Although this process has been examined in detail for cytosolic proteins, how endoplasmic reticulum (ER)-tethered, aggregation-prone proteins are handled is ill-defined. To determine how a membrane protein with a cytoplasmic aggregation-prone domain is routed for ER-associated degradation (ERAD), we analyzed a new model substrate, TM-Ubc9ts. In yeast, we previously showed that TM-Ubc9ts ERAD requires Hsp104, which is absent in higher cells. In transient and stable HEK293 cells, we now report that TM-Ubc9ts degradation is largely proteasome-dependent, especially at elevated temperatures. In contrast to yeast, clipped TM-Ubc9ts polypeptides, which are stabilized upon proteasome inhibition, accumulate and are insoluble at elevated temperatures. TM-Ubc9ts cleavage is independent of the intramembrane protease RHBDL4, which clips other classes of ERAD substrates. These studies highlight an unappreciated mechanism underlying the degradation of aggregation-prone substrates in the ER and invite further work on other proteases that contribute to ERAD.
RCN1 deficiency inhibits oral squamous cell carcinoma progression and THP-1 macrophage M2 polarization
Authors: Liu Han , Guo Haiyang , Wu Yuehan , Hu Qiannan , Hu Guangbing , He Huan , Yin Yaolin , Nan Xiaoxu , Lin Gaoren , Han Jinpeng , Zhao Runzhe , Liu Ying
Published: December 2023

Reticulocalbin 1 (RCN1), a calcium-binding protein located in the endoplasmic reticulum (ER) lumen, contains six conserved regions. Its main functions include maintaining intracellular homeostasis and regulating cell proliferation and apoptosis, and it plays an important role in the development of various tumours. However, the exact function of RCN1 in oral squamous cell carcinoma (OSCC) is not fully understood. Therefore, the aim of this study was to investigate the effects of RCN1 on the biological behaviour of OSCC and the regulation of tumour-associated macrophage (TAM) polarization. The expression of RCN1 in OSCC and normal oral mucosa was evaluated through bioinformatics analysis and immunohistochemical staining. The growth, migration, and invasion of OSCC cells were observed after knockdown of RCN1 using CCK-8 and Transwell assays. Apoptosis was detected by flow cytometry. The effect of tumour cell-derived RCN1 on the polarization of THP-1 macrophages was investigated by establishing a coculture model of THP-1 macrophages and OSCC cells. Additionally, changes in the expression levels of relevant proteins were detected using Western blotting. The upregulation of RCN1 in tumour tissues compared to normal oral mucosal tissues is associated with a poor prognosis and can be utilized as a prognostic indicator for OSCC. Knockdown of RCN1 inhibited the proliferation, migration, and invasion of OSCC cells. Additionally, knockdown of RCN1 in Cal-27 and SCC-25 cells resulted in inhibition of the M2 polarization of THP-1 macrophages. RCN1 knockdown inhibits OSCC progression and M2 macrophage polarization. Targeting RCN1 may be a promising approach for OSCC treatment.
Effect of different modification by gold nanoparticles on the electrochemical performance of screen-printed sensors with boron-doped diamond electrode
Authors: Matvieiev Oleksandr , Šelešovská Renáta , Marton Marián , Hatala Michal , Metelka Radovan , Weis Martin , Vojs Marian
Published: December 2023

Screen-printed sensors with chemically deposited boron-doped diamond electrodes (BDDE) were modified with different types of gold nanoparticles (AuNPs) according to a new original procedure. Physically and electrochemically deposited AuNPs had various sizes and also nanoporous character. They also differ in shape and density of surface coverage. The developed sensors were characterized using scanning electron microscopy and Raman spectroscopy. Their electrochemical properties were studied using cyclic voltammetry and electrochemical impedance spectrometry of selected outer sphere ([Ru(NH3)6]Cl3) and inner sphere (K3[Fe(CN)6], dopamine) redox markers. The application possibilities of such novel screen-printed sensors with BDDE modified by AuNPs were verified in the analysis of the neurotransmitter dopamine. The best analytical performance was achieved using printed sensors modified with the smallest AuNPs. The achieved limit of detection values in nanomolar concentrations (2.5 nmol L−1) are much lower than those of unmodified electrodes, which confirms the significant catalytic effects of gold nanoparticles on the surface of the working electrode. Sensors with the best electrochemical properties were successfully applied in the analysis of a model solution and spiked urine samples.
Association between brain cancer immunogenetic profile and in silico immunogenicities of 11 viruses
Authors: Georgopoulos Apostolos P. , James Lisa M.
Published: December 2023

Several viruses including human herpes viruses (HHVs), human polyomavirus JCV, and human papilloma virus (HPV) have been implicated in brain cancer, albeit inconsistently. Since human leukocyte antigen (HLA) is centrally involved in the human immune response to viruses and has been implicated in brain cancer, we evaluated in silico the immunogenicity between 69 Class I HLA alleles with epitopes of proteins of 9 HHVs, JCV, and HPV with respect to a population-based HLA-brain cancer profile. We found that immunogenicity varied widely across HLA alleles with HLA-C alleles exhibiting the highest immunogenicity, and that immunogenicity scores were negatively associated with the population-based HLA-brain cancer profile, particularly for JCV, HHV6A, HHV5, HHV3, HHV8, and HHV7. Consistent with the role of HLA in foreign antigen elimination, the findings suggest that viruses with proteins of high HLA immunogenicity are eliminated more effectively and, consequently, less likely to cause brain cancer; conversely, the absence of highly immunogenic HLA may allow the viral antigens to persist, contributing to cancer.
Development of a nomogram to predict survival in advanced biliary tract cancer
Authors: Imaoka Hiroshi , Ikeda Masafumi , Nomura Shogo , Morizane Chigusa , Okusaka Takuji , Ozaka Masato , Shimizu Satoshi , Yamazaki Kentaro , Okano Naohiro , Sugimori Kazuya , Shirakawa Hirofumi , Mizuno Nobumasa , Satoi Sohei , Yamaguchi Hironori , Sugimoto Rie , Gotoh Kunihito , Sano Keji , Asagi Akinori , Nakamura Kazuyoshi , Ueno Makoto
Published: December 2023

The prognosis of advanced biliary tract cancer (BTC) patients remains poor due to limited efficacy of chemotherapy and difficulties in management. Thus, prediction of survival is crucial for the clinical management of advanced BTC. The aim was to develop and validate a nomogram to predict 6-month and 12-month survival in advanced BTC patients treated with chemotherapy. A multivariable Cox regression model was used to construct a nomogram in a training set (JCOG1113, a phase III trial comparing gemcitabine plus S-1 [GS] and gemcitabine plus cisplatin, n = 351). External validity of the nomogram was assessed using a test set (JCOG0805, a randomized, phase II trial comparing GS and S-1 alone, n = 100). Predictive performance was assessed in terms of discrimination and calibration. The constructed nomogram included lymph node metastasis, liver metastasis, carbohydrate antigen 19-9, carcinoembryonic antigen, albumin, and C-reactive protein. Uno’s concordance index was 0.661 (95% confidence interval [CI] 0.629–0.696) in the training set and 0.640 (95% CI 0.566–0.715) in the test set. The calibration plots for 6-month and 12-month survival showed good agreement in the two analysis sets. The present nomogram can facilitate prediction of the prognosis of advanced BTC patients treated with chemotherapy and help clinicians’ prognosis-based decision-making.
Animal Product-derived Flame Retardants
Authors: Malucelli Giulio , Zhang Lu , Wang De-Yi , Zhang Yan
Published: December 2023

Driven by the increased sustainability awareness in both fire retardants and the environment, recent years have witnessed the use of animal products as a new class of bio-based fire retardants for polymeric materials. Animal-derived products, such as animal proteins (e.g., DNA), dopamine (DA) and others (e.g., eggshells, oyster shells and wool), have been explored to be used to create fire-retardant materials. This chapter summarizes the historical development of animal product-derived fire retardants and provides and highlights some successful examples of their use for different types of polymeric matrices, as well as their possible fire-retardant mechanisms. Following this, their key limitations are briefed as well followed by a discussion of some future perspectives.
A DNA octahedral amplifier for endogenous circRNA detection and bioimaging in living cells and its biomarker study
Authors: Feng Rong , Yu Shengrong , Qian Zhiling , Wang Yiming , Xie Gege , Li Bingqian , Chen Jingwen , Wu Yong-Xiang , Tang Keqi
Published: December 2023

A DNA octahedral amplifier (DOA) nanoprobe was constructed as a fluorescence assay platform forin situFRET detection and bioimaging of circRNA in living cells.
The design of a series of cocrystals featuring dicarboxylic acid with a modified isoniazid derivative
Authors: Scheepers Matthew C. , Lemmerer Andreas
Published: December 2023

Five cocrystals featuring a modified isoniazid derivative (N′-(propan-2-ylidene)pyridine-4-carbohydrazide) with aliphatic dicarboxylic acids with varying chain lengths was synthesized and characterized.
Dual control of passive light output direction by light and mechanical forces in elastic crystals
Authors: Han Chuchu , Yang Jing , Zhang Xin , Li Aisen , Peng Jiang
Published: December 2023

An organic crystal with photomechanical and elastic properties has been prepared.
Crystal growth, luminescence, and scintillation properties of Zn2Te3O8 crystal for 0νββ decay search
Authors: Khan Arshad , Kim H. J. , Kim Yeongduk , Lee Moo Hyun , Abdalla Ayman M. , Algethami Jari S.
Published: December 2023

A single crystal of Zn2Te3O8 (ZTO) was grown using the conventional Czochralski technique.
Bandwidth of quantized surface plasmons: competition between radiative and nonradiative damping effects
Authors: Moustafa Samar , Zayed Mohamed K. , Ahmed Moustafa , Fares Hesham
Published: December 2023

Geometrical and material characteristics of nanospheres/nanoshells significantly influence the competition between radiative and nonradiative damping that determines the plasmon bandwidth.
Recent advancements in CeO2-enabled liquid acid/base catalysis
Authors: Zhang Mingkai , Zhang Sai , Qi Zening , Xie Min , Qu Yongquan
Published: December 2023

Owing to the existence of surface acidic/basic sites, CeO2 has demonstrated significant potential for acid/base catalysis.
Synergistic regulation of Li deposition on F-doped hollow carbon spheres toward dendrite-free lithium metal anodes
Authors: Man Jianzong , Yin Jinpeng , Liu Wenlong , Sun Xiaodong , Wang Dong , Cui Yongfu , Sun Juncai
Published: December 2023

The notorious issues of lithium (Li) dendrite growth and volume change hinder the practical applications of Li metal anodes.
Age differences in the impact of dietary salt on metabolism, blood pressure and cognitive function in male rats
Authors: Sun Fen , Zhang Jin-Yang , Zhao Lu-Ping , Jin Qi , Jin Chao , Wang Qiu-Xiang , Xu Jun-Tao , Yin Meng-Jia
Published: December 2023

There are age differences in the effects of varying salt intake on the metabolism, survival rate, blood pressure levels, blood pressure variability, heart rate, and cognition in male rats.
1D MnSe@carbon nanofiber as a high-rate anode for sodium-ion batteries: electrochemical and ex situ mechanistic investigation of Na+ charge storage
Authors: Sujithkrishnan Elayaperumal , Ragul Sivasubramaniam , Hussain Shamima , Harika Villa Krishna , Elumalai Perumal
Published: December 2023

1D MnSe@CNF was synthesized by means of an electrospinning technique. The MnSe@CNF anode exhibited an enhanced specific capacity of 725 mA h g−1. The deconvolution of the cyclic voltammetry profiles revealed that Na+ charge storage was a blend of diffusion and significant capacitive storage.
Intracellular self-aggregation of biomimetic Fe3O4 nanoparticles for enhanced ferroptosis-inducing therapy of breast cancer
Authors: Zhang Zhendong , Xie Beibei , Lu Xiaojie , Xiong Lishan , Li Xinyuan , Zhang Yan , Li Chunlai , Wang Chenhui
Published: December 2023

A supramolecular and cell membrane co-modified drug delivery system was constructed to enhance Fe3O4 and SAS synergistically induced ferroptosis anti-tumor therapy.
Large polarons in two-dimensional fullerene networks: the crucial role of anisotropy in charge transport
Authors: Cassiano T. S. A. , Pereira M. L. , e Silva G. M. , de Oliveira Neto P. H. , Ribeiro L. A.
Published: December 2023

The recent synthesis of a two-dimensional quasi-hexagonal-phase monolayer network of C60 molecules, known as qHPC60, holds significant promise for future semiconductor applications.
Chemically exfoliated boron nanosheets for efficient oxidative dehydrogenation of propane
Authors: Zhang Dake , Wang Shenghua , Zhang Chengcheng , He Le , Sun Wei
Published: December 2023

We report that boron in the form of nanosheets can be prepared feasibly by exfoliating layered MgB2 with hydrochloric acid, and can efficiently and stably catalyze oxidative dehydrogenation of propane.
Large-area single-crystal TMD growth modulated by sapphire substrates
Authors: Chen Lina , Cheng Zhaofang , He Shaodan , Zhang Xudong , Deng Kelun , Zong Dehua , Wu Zipeng , Xia Minggang
Published: December 2023

In this review, we provide an insightful overview of different epitaxial mechanisms and growth behaviours associated with the atomic structure of sapphire surfaces and the growth parameters.
Multi-tunable thermoresponsive behaviors of poly(amido thioether)s
Authors: Lian Lu , Wang Qingqing , Duan Fujin , Zhao Youliang
Published: December 2023

Compared with polyacrylamides comprising the same side groups, poly(amido thioether)s with an oxidizable and amide-bearing backbone can exhibit more intriguing multi-tunable thermoresponsive behaviors.
Aluminium-based ionic liquid grafted on biochar as a heterogeneous catalyst for the selective synthesis of tetrazole and 2,3-dihydroquinazolin 4(1H)-one derivatives
Authors: Norouzi Masoomeh , Moradi Parisa , Khanmoradi Maryam
Published: December 2023

2,3-Dihydroquinazolin-4(1H)-one and tetrazole are a class of nitrogen-containing heterocyclic compounds that play an important role in drug design and are an important part of many biological and industrial compounds.
Main and papain-like proteases as prospective targets for pharmacological treatment of coronavirus SARS-CoV-2
Authors: Yevsieieva Larysa V. , Lohachova Kateryna O. , Kyrychenko Alexander , Kovalenko Sergiy M. , Ivanov Volodymyr V. , Kalugin Oleg N.
Published: December 2023

The review outlines coronavirus SARS-CoV-2 morphology, life cycle, and essential proteins, focusing on a design strategy for dual-acting inhibitors for PLpro and Mpro proteases.
A domino reaction for the synthesis of pyrrolo[2,1-a]isoquinolines from 2-aryl-pyrrolidines and alkynes promoted by a four-component catalytic system under aerobic conditions
Authors: Luo Zheng , Hu Huayou , Wang Chao , Yang Zhen , Wang Yefei
Published: December 2023

Pyrrolo[2,1-a]isoquinoline derivatives were synthesized from 2-aryl-pyrrolidines and alkynes via an oxidative dehydrogenation/cyclization coupling/dehydrogenative aromatization domino process.
Mn(iii)-mediated carbon-centered radicals generate an enhanced immunotherapeutic effect
Authors: Li Jiaxuan , Hu Baifei , Chen Zelong , Li Jiahui , Jin Wenjuan , Wang Yi , Wan Yichen , Lv Yinghua , Pei Yuxin , Liu Hongtao , Pei Zhichao
Published: December 2023

A highly effective cancer therapeutic nanovaccine could modulate tumor microenvironment to enhance photodynamic therapy on immunogenic cell death (ICD) induction and favor Mn(iii)-mediated C-centered radical (˙R) generation to further strengthen ICD.
13Ccarbene nuclear magnetic resonance chemical shift analysis confirms CeIVC double bonding in cerium(iv)–diphosphonioalkylidene complexes
Authors: Baker Cameron F. , Seed John A. , Adams Ralph W. , Lee Daniel , Liddle Stephen T.
Published: December 2023

A combined solid-state NMR and DFT computational shielding study confirms the presence of CeC double bonds in cerium–diphosphonioalkylidene complexes.
NiH-catalyzed C–N bond formation: insights and advancements in hydroamination of unsaturated hydrocarbons
Authors: Lee Changseok , Kang Hyung-Joon , Hong Sungwoo
Published: December 2023

This review highlights recent progress in NiH-catalyzed hydroamination, focusing on its application to a variety of alkenes and alkynes.
Enhancing the textural and rheological properties of fermentation-induced pea protein emulsion gels with transglutaminase
Authors: Masiá Carmen , Ong Lydia , Logan Amy , Stockmann Regine , Gambetta Joanna , Jensen Poul Erik , Rahimi Yazdi Saeed , Gras Sally
Published: December 2023

The aim of this study was to assess how transglutaminase (TG) impacts the microstructure, texture, and rheological properties of fermentation-induced pea protein emulsion gels.
Correction: Achieving highly efficient CO2 to CO electroreduction exceeding 300 mA cm−2 with single-atom nickel electrocatalysts
Authors: Jeong Hui-Yun , Balamurugan Mani , Choutipalli Venkata Surya Kumar , Jeong Eun-suk , Subramanian Venkatesan , Sim Uk , Nam Ki Tae
Published: December 2023

Correction for ‘Achieving highly efficient CO2 to CO electroreduction exceeding 300 mA cm−2 with single-atom nickel electrocatalysts’ by Hui-Yun Jeong et al., J. Mater. Chem. A, 2019, 7, 10651–10661, https://doi.org/10.1039/C9TA02405K.
Implementation of Above-Cuff Vocalization After Tracheostomy Is Feasible and Associated With Earlier Speech
Authors: Gajic Srdjan , Jacobs Lauren , Gellentien Catherine , Dubin Randy M. , Ma Kevin
Published: December 2023

Purpose:

The purpose of this study was to assess the feasibility of hospital-wide implementation of an above-cuff vocalization (ACV) protocol using ACV-capable tracheostomy tubes and its impact on patient speech in four intensive care unit (ICU) patient populations.

Method:

This research was an observational pre–post study that was conducted over a 26-month period and included 323 critically ill adult ICU patients who underwent tracheostomy in a 365-bed academic tertiary care hospital. ACV was assessed using a protocol developed by a multidisciplinary team. Presence of speech was defined as at least one comprehensible word spoken during a speech-language pathologist evaluation.

Results:

Median time-to-speech was 13 days (interquartile range [IQR]: 8–20 days) before the intervention, compared to 9 days (IQR: 6–16 days) after the intervention (
p
= .0017). In the pre-intervention group, 101 out of 167 (60.5%) patients achieved speech within 60 days, compared to 83 out of 133 (62.4%) patients in the post-intervention group (
p
= .12). Of the 83 patients who achieved speech in the post-intervention group, 24 (28.9%) did so via ACV, with the remainder using a speaking valve or digital occlusion. Of those 24 patients, seven did not progress to using a speaking valve within the follow-up period. The median number of speech days gained by using ACV was 8 (IQR: 5–18 days). ACV was successful in facilitating speech in 24 out of 29 (82.8%) patients trialed, with no major complications.

Conclusions:

Routine implementation of ACV after tracheostomy is feasible, safe, and associated with earlier speech in a diverse population of critically ill patients. ACV is an important method to facilitate communication in patients requiring mechanical ventilation with tracheostomy cuff inflation.
Adaptive Weighted Face Alignment by Multi‐Scale Feature and Offset Prediction
Authors: Li Jingwen , Liang Jiuzhen , Liu Hao , Hou Zhenjie
Published: December 2023

Traditional heatmap regression methods have some problems such as the lower limit of theoretical error and the lack of global constraints, which may lead to the collapse of the results in practical application. In this paper, we develop a facial landmark detection model aided by offset prediction to constrain the global shape. First, the hybrid detection model is used to roughly locate the initial coordinates predicted by the backbone network. At the same time, the head rotation attitude prediction module is added to the backbone network, and the Euler angle is used as the adaptive weight to modify the loss function so that the model has better robustness to the large pose image. Then, we introduce an offset prediction network. It uses the heatmap corresponding to the initial coordinates as an attention mask to fuze with the features, so the network can focus on the area around landmarks. This model shares the global features and regresses the offset relative to the real coordinates based on the initial coordinates to further enhance the continuity. In addition, we also add a multi‐scale feature pre‐extraction module to preprocess features so that we can increase feature scales and receptive fields. Experiments on several challenging public datasets show that our method gets better performance than the existing detection methods, confirming the effectiveness of our method.
Auxiliaries’ power and energy demand prediction of battery electric vehicles using system identification and deep learning
Authors: Schäfers Lukas , Franke Kai , Savelsberg Rene , Pischinger Stefan
Published: December 2023

The energy demand of the auxiliaries of battery electric vehicles can account for a significant share of the total energy demand of a trip and must be taken into account for the prediction of the vehicle's remaining driving range or the implementation of predictive driving functions. This paper investigates a method that uses system identification and neural networks with bidirectional long short‐term memory layers to predict the power requirements of the auxiliaries depending on information that is known prior to the trip. By using a self‐learning, data‐driven approach as well as data that can be measured without additional instrumentation, a prediction is made possible without the need to design detailed physical models in advance. Additionally, a rule‐based allocation of the training data based on environmental conditions is implemented, which serves to adapt individual models to different climatic modes of the thermal system. The potential of the method is demonstrated for three different systems showing a prediction accuracy of on average 3% to 8% in terms of energy, while the deviation of the predicted power consumption is on average about 500 watts. Due to the complete automation of the process, a further increase in prediction accuracy can be expected.
Design and control of modular multilevel matrix converter with symmetrically integrated energy storage for low frequency AC system
Authors: Tang Yingjie , Zhang Zheren , Xu Zheng
Published: December 2023

Integrating energy storage units (ESUs) into part of sub‐modules (SMs) enables the decoupling active power control for the modular multilevel matrix converter (M3C). The low frequency AC (LFAC) system based on M3C with symmetrically integrated energy storage (SI‐AM3C) can provide functions such as renewable power fluctuation smoothing and other power grid auxiliary services, which is attractive in engineering practices. This paper focuses on the design and control of SI‐AM3C. For the converter design, an evaluation method for the number of required active SMs (ASMs) is presented. On this basis, the influences of different system operating conditions on the ASM requirement are analyzed in case studies, and the effects of specific circulating injection strategies are also investigated. The control system targeted at decoupled AC side active power for SI‐AM3C is introduced. A modified inner‐arm capacitor voltage balance strategy is introduced to reduce the capacitor voltage deviation between ASMs and passive SMs (PSMs). The conclusions related to the presented estimation method and converter control strategy are verified by time‐domain simulations in PSCAD/EMTDC.
Comparative analysis of different methods in estimating wind speed distribution, and evaluation of large‐scale wind turbine performance in Rahva‐Bitlis, Turkey
Authors: Oral Faruk
Published: December 2023

In this study, wind characteristics and electricity generation potential from wind energy were investigated in the Bitlis‐Rahva region in eastern Turkey. Ten‐minute wind data from the Bitlis meteorological station were used in the study. The determination of the wind speed (WS) distribution was carried out using the WindPRO program together with the Weibull and Rayleigh distributions. R2, RMSE, and χ2 goodness‐of‐fit tests were used to measure the accuracy of the velocity distribution process. A digital elevation model of the power generation site was created to evaluate wind data and predict turbine performance. Wind power generation performance was evaluated using five different wind turbines (WTs). A power curve model was developed for the WTs to determine the capacity for energy generation. According to the error tests, it has been determined that the results obtained with the WindPRO program can represent the observed wind data most accurately. The results from the WindPRO program analysis showed an average annual WS of 3.26 m/s and a power density of 49.77 W/m2. Increasing height was found to increase WS and power density. The prevailing wind direction was found to be South‐Southwest with a frequency value of 27.5%. The largest capacity factor was obtained from the WT with the largest rotor diameter and rated power. Out of all the WTs examined, the turbine with the largest rated power and rotor diameter produced the greatest amount of energy. According to the capacity factor values calculated for the selected WTs, the region is not considered efficient for wind energy investments. However, as WS and power density increase with increasing altitude, it is thought that different higher parts of the region may be more efficient in terms of wind energy utilization.
Frecuencia de riego en variedades tintas: Repercusión en la producción y la composición de la uva, durante un periodo bienal, en 4 regiones de España
Authors: Yuste Jesús , Montoro A. , Cancela J.J. , Martínez-Porro D. , Mancha L.A. , Moreno D. , Torija I. , Rodríguez-Febereiro M. , Vilanova M. , Uriarte D.
Published: December 2023

La restricción hídrica es un aspecto limitante del cultivo del viñedo en muchas regiones, por lo que el riego constituye uno de los principales factores determinantes de su desarrollo en muchas zonas, que ha sido estudiado en diferentes ámbitos, pero la frecuencia de aplicación del riego, que afecta a su distribución en el suelo y puede influir en el comportamiento del viñedo, no ha sido suficientemente evaluada, por lo que su estudio resulta de gran interés en diversas condiciones de cultivo. El objetivo de este trabajo fue evaluar los efectos de cuatro frecuencias de riego deficitario del 30% ET0: 7 riegos por semana (T01), 2 riegos por semana (T03), 1 riego por semana (T07) y 1 riego cada dos semanas (T15), en la producción de uva y la composición de la baya. El experimento se desarrolló durante los años 2021 y 2022, en viñedos de Garnacha Tinta (en Badajoz: T03, T07, T15), Tempranillo (en Valladolid: T03, T07, T15), Syrah (en Albacete: T03 y T07) y Mencía (en Lugo: T01, T03, T07). Tanto la producción como la composición de la uva fueron determinadas en vendimia.

Las diferentes frecuencias de riego han repercutido en el rendimiento y la calidad de la uva de forma variable según la variedad, la localización y el año. La producción de uva y la madera de poda se vieron ligeramente favorecidos por la frecuencia T07 con respecto a T03 en Garnacha y, sólo en la producción, en Tempranillo, mientras que ocurrió lo contrario en Syrah y Mencía. La concentración de azúcares se vio ligeramente favorecida por la frecuencia T07 en Syrah y, parcialmente, en Tempranillo. El pH del mosto no ofreció una respuesta apreciable derivada de la frecuencia de riego. La acidez total mostró valores ligeramente superiores de T07 en Garnacha y Tempranillo, pero algo más altos de T03 en Syrah y Mencía. El ácido tartárico apenas presentó una ligera tendencia favorable a T07 en Garnacha, mientras que el ácido málico mostró una tendencia ligeramente favorable a T07 en Garnacha y Mencía, pero beneficiosa para T03 en Syrah. El contenido de potasio y de polifenoles totales ofreció una clara variabilidad entre frecuencias de riego en general, aunque el primero mostró un ligero aumento del T03 con respecto al T07 en Mencía y el segundo un ligero aumento del T07 frente al T03 en Syrah. En definitiva, los efectos productivos y cualitativos derivados de la frecuencia de riego aplicada han tenido un alcance reducido, que, sin embargo, puede variar moderadamente en función de la variedad y del año.
Comparison of the influence of Saccharomyces pastorianus to Saccharomyces cerevisiae and Saccharomyces bayanus inoculation ratio to oenological characteristics of Sauvignon Blanc wine
Authors: Vicky Troianou , Maria Dimopoulou , Yves Gosselin , Etienne Dorignac , Yorgos Kotseridis
Published: December 2023

The aim of our work was to evaluate the impact of different fermentation schemes by using mixed and pure cultures of S. pastorianus and S. cerevisiae or S. bayanus. For the mixed fermentation schemes, one strain of S. pastorianus has been inoculated under different proportions (99%/1%, 97%/3%, 95%/5%, 90%/10% and 70%/30% w/w) in co-inoculation with two commercial strains of S. cerevisiae and one commercial Saccharomyces bayanus strain. The fermentation kinetics has been controlled by density measurement and classical oenological analyses were performed based on OIV analytical methods. The population dynamics was evaluated by the specific interdelta PCR reaction of the Saccharomyces species in the beginning and in the end of the fermentation process. Volatile compounds of the wine aroma, such as esters, higher alcohols and thiols were analyzed by GC/MS. Sensory assessment by trained panel was carried out for all wines. The wines fermented with S. pastorianus, either in pure or mixed cultures, were characterized by significantly lower acetic acid production and higher malic acid degradation when compared to the wines fermented with S. cerevisiae strains. The presence of S. pastorianus strain enhanced the production of the varietal thiols when compared to the samples fermented with the S. cerevisiae pure cultures. The wines produced by the S. bayanus or cerevisiae monocultures and the ones produced by the co-culture with S. pastorianus at 70%-30% ratio (S. pastorianus to S. bayanus or cerevisiae) were overall better rated from a sensory point of view.
Controlling B. bruxellensis with Pulsed Electric Fields: Optimization of industrial protocols and impact on the wine profile
Authors: Aguiar-Macedo Mafalda , Pereira Marcos Teotónio , Redondo Luís Manuel , Silva Carlos
Published: December 2023

Pulsed electric field application for microbial inactivation of wine spoilage microorganisms has recently become a point of interest among scientific and industry peers. B. bruxellensis is considered one of the most undesirable spoilage yeast in wines. Thus, this assay has the objective of contributing to better understanding the effect of PEF, not only on the inactivation of B. bruxellensis and impact on Total Yeast population, but also on physico-chemical and sensorial quality. 2 sets of red wine were subjected to a 15 kV/cm and 35 kJ/Kg PEF treatment at pilot-plant scale (240 L/h, 4 bar); one wine was naturally contaminated with B. bruxellensis, being used for microbial assessment, while the wine deemed free of contamination was subjected to physico-chemical and sensorial analysis prior and after the application of PEF. B. bruxellensis was effectively inactivated using a conservative PEF treatment of 15 kV/cm and 35 kJ/kg, resulting in a reduction from 2.467 x 10^3 viable cells/mL to below the detection limit of <150 viable cells/mK; Total Yeast Count decreased 80,66%. The treatment posed a ∆T = +8,5 ºC. Sensorial analysis concluded no significative differences. Small, but significant differences were found at physico-chemical level.
RETRACTED: Management of Sustainable Development of Car Service Enterprises
Authors: Dembitskyi Valerii , Murovanyi Igor , Maiak Mykola , Pavlova Iryna , Popovych Pavlo , Borysiak Olena , Brych Vasyl , Karolina Mucha-Kuś
Published: December 2023

See the retraction notice E3S Web of Conferences 456, 00002 (2023), https://doi.org/10.1051/e3sconf/202345600002
RETRACTED: Case Studies in Management Science Research for Digitalization and Sustainability Development
Authors: Dzwigol Henryk
Published: December 2023

See the retraction notice E3S Web of Conferences 456, 00002 (2023), https://doi.org/10.1051/e3sconf/202345600002
RETRACTED: Cryptocurrency Adoption and Its Implications: A Literature Review
Authors: Rajharia Poonam , Kaushik Madhu Bala
Published: December 2023

See the retraction notice E3S Web of Conferences 456, 00002 (2023), https://doi.org/10.1051/e3sconf/202345600002
Retracted Article: Educational Marketing Tools on the Way to Costumer: Analogies with Approaches in Technical Systems Description
Authors: Artyukhova Nadiia , Artyukhov Artem , Rehak Robert , Vasylieva Tetyana
Published: December 2023

The authors have expressed the wish to retract this article on the grounds that the list of references is incorrect.

The Publisher and Editor(s) approved to the retraction.
Vibrocreep of sand at different exposure frequencies
Authors: Sobolev Evgeniy , Anzhelo George
Published: December 2023

The main purpose of this study is to substantiate the relationship between the coefficient of vibrocreep and the frequency of dynamic vibration exposure based on laboratory dynamic triaxial tests using sandy soil as an example. These studies were carried out as part of the design of new metro stations and tunnels in the city of Moscow. As a result of the tests performed, experimental dependences were obtained between the value of the coefficients of vibrocreep, the frequency of dynamic vibration impact and the value of lateral pressure in the chamber of a triaxial device, which, in fact, characterizes the depth of the studied soils. It has been established that with an increase in the value of the lateral pressure, the value of the vibration soundness coefficient also increases. At the same time, with an increase in the frequency of dynamic action, a decrease in the coefficient of vibrocreep is observed. The obtained dependences allow predicting the vibrocreep of sandy soils depending on the depth of occurrence and the intensity of the dynamic impact. The scientific novelty of the performed research lies in the generalization of a large number of unique laboratory studies performed in order to predict the vibrocreep of sandy soil and develop new geomechanical models of soil behaviour under dynamic man-made impacts.
Natural resources as the basis for the economic and environmental characteristics of construction projects
Authors: Kulakov Kirill , Filippova Tatiana
Published: December 2023

The purpose of the publication is to consider the economic and environmental characteristics of facilities. The environmental component of natural resources is considered as a component of production processes at different stages of the facility creation. The economic component of natural resources is determined by the relevance of the ratio of costs and profits. The methods used for the study (differential rent, economic method of environmental management, methods of calculating environmental and economic damage) involve a comprehensive consideration of the natural resource: the land plot. The value and investment attractiveness of one or another of the natural resources (land plots) in any case is made taking into account additional costs and, of course, a cumulative assessment of environmental indicators in the external environment. The obtained results confirm the solution of the issues of the balance of economic and environmental indicators in the implementation of construction projects. A comparison is presented to determine the differential rent of land plots with different natural conditions, but potentially investment-attractive in terms of conditions sufficient for the organization of construction production. Typical indicators that characterize the economic and natural effects are considered taking into account the characteristics of the implemented construction project at different stages of its life cycle.
Improving the performance of the vapor compression cycle using an internal heat exchanger
Authors: Ermakov Andrey , Salakhov Richat , Khismatullin Renat
Published: December 2023

The main additional consumer of electrical energy in an electric bus is the climate system, which can consume up to 30% of electrical energy. This problem is especially relevant in Russia at low ambient temperatures. The optimal solution is to switch the vapor compression unit to heat pump mode. However, at low temperatures, its efficiency decreases and performance is insufficient. One way to improve efficiency is to use an internal heat exchanger. In this paper, we studied the effect of an internal heat exchanger on the performance of a vapor compression cycle using R290, R410a and R507a refrigerants. The influence of geometry on the performance of the internal heat exchanger is determined. The use of an internal heat exchanger makes it possible to increase coefficient of performance by 10-13%.
Valeurs humaines et attitude à l’égard du spectacle sportif médiatique : une approche psycho-sociologique
Authors: Souchon Nicolas , Dalla Pria Yan , Leroux Nathalie , Bardin Brigitte
Published: December 2023

Objectif :L’objectif de cette étude est de tester les relations potentielles qui pourraient exister entre les différentes valeurs du modèle affiné de Schwartzet al.(2012) [Schwartz, S.H., Cieciuch, J., Vecchione, M., Davidov, E., Fischer, R., Beierlein, C., Ramos, A., Verkasalo, M., Lönnqvist, J.E., Demirutku, K., Dirilen-Gumus, O., & Konty, M. (2012). Refining the theory of basic individual values.Journal of Personality and Social Psychology, 103, 663–688.] et l’attitude à l’égard du spectacle sportif médiatique (SSM).Méthodologie : 383 étudiants de l’université Paris Lumière (Mage = 23,46,ET = 6,78 ; 178 femmes, Mage = 24,66,ET = 8,50, 209 étudiants en STAPS,Mage = 20,92,ET = 2,70) ont rempli le PVQ RR57 afin de mesurer les 19 catégories de valeurs du modèle de Schwartz, et ont répondu à 7 questions permettant de mesurer leur attitude à l’égard du SSM.Résultats : Les analyses de régressions montrent que les valeurs de réussite, de tradition et de réputation prédisent une attitude positive à l’égard du SSM, alors que les valeurs de bienveillance et d’humilité prédisent une attitude négative à l’égard du SSM.Conclusion et perspectives : Les résultats apportent un éclairage intéressant sur le SSM et les valeurs qu’il véhicule, et cela d’autant plus que le genre des participants et le type d’études (STAPS/non STAPS) ont modéré les résultats obtenus.
Leichter atmen – wie funktionieren Ventile bei
COPD?
Authors: Schneemann Enrico
Published: December 2023

Bei chronisch obstruktiver Lungenerkrankung (COPD) und Lungenemphysem kommt es zu
einer fortschreitenden Verengung der Atemwege, die das Atmen erschwert. Eine
etablierte Behandlungsoption, die bronchoskopische Ventilimplantation, bietet
Patienten eine Möglichkeit, das Atmen zu erleichtern. Diese Ventile
funktionieren, indem sie überblähte Lungenlappen kollabieren
lassen, was die Funktion des gesunden Lungengewebes verbessert. Dieser Artikel
erläutert, wie diese Ventile funktionieren und wie sie bei der
Behandlung von COPD und Lungenemphysem eingesetzt werden.
ESNO Publikation – wie liest man eine wissenschaftliche Arbeit für die Pflege?
Authors: Beilenhoff Ulrike
Published: December 2023

Der europäische Dachverband European Specialist Nurses Organisation (ESNO) hat einen sehr gut strukturierten Artikel publiziert, der einen Überblick über die Charakteristika der verschiedenen Publikationsformen gibt. Der Leitfaden soll helfen,
Zytologischer Nachweis eines hepatozytotropen T-Zell-Lymphoms bei
einem 15 Jahre alten Kater
Authors: Finsterhölzl Alina , Müller Janina , Gaum Sabine , Henrich Manfred , Bauer Natali
Published: December 2023

Die Kasuistik beschreibt ein seltenes Phänomen der
Emperipolese-ähnlichen Invasion von lymphatischen Blasten in die
Hepatozyten eines 15 Jahre alten Europäisch Kurzhaar-Katers. Der Kater
wurde mit unspezifischen Symptomen (Inappetenz und Gewichtsverlust) vorgestellt.
Die zytologische Untersuchung eines ultraschallgestützt entnommenen
Feinnadelaspirates der Leber zeigte einige Hepatozyten mit einer
Emperipolese-ähnlichen Invasion von lymphatischen Blasten. Ganz
vereinzelte extrazellulär gelegene lymphatische Blasten wiesen eine
Erythrophagie auf. Nach der zytologischen Diagnosestellung eines
großzelligen Lymphoms wurde der Kater nach einer zweiwöchigen
Monotherapie mit Prednisolon aufgrund seines schlechten Allgemeinbefindens
euthanasiert. Zur Bestätigung der zytologischen Verdachtsdiagnose eines
hepatozytotropen Lymphoms erfolgte eine postmortale Probenentnahme aus der
Leber. Die Histopathologie konnte die zytologischen Befunde bestätigen.
Immunhistochemisch waren die lymphatischen Zellen CD3 positiv, sodass die
Diagnose eines bisher nur selten beschriebenen hepatozytotropen T-Zell-Lymphoms
gestellt werden konnte.
Gendered vulnerabilities to climate change and farmers’ adaptation responses in Kwara and Nassarawa States, Nigeria
Authors: Ayanlade Ayansina , Oluwatimilehin Isaac A. , Ayanlade Oluwatoyin S. , Adeyeye Olajumoke , Abatemi-Usman Sa’adatu
Published: December 2023

This study examines gender vulnerabilities and responsive strategies to climate change, comparing evidences from Kwara and Nassarawa States in Nigeria. Changes in climate parameters, gender-based perceptions of climate, as well as gender-based response and adaptation practices were assessed in accordance with specific research objectives. A total of 200 participants were surveyed through a mixed method approach using 41 years of climate data. Semi-structured questionnaires were administered equally in the two States and 52 in-depth interviews were conducted within male and female farmers that were 40 years and above age using a purposive sampling method. Results from Nassarawa State showed a downward trend in rainfall and an upward trend in both minimum and maximum temperatures. The farmers perceived climate change differently, with observed changes in climate variables: temperature and precipitation, resulting in extreme floods, drought, and rainfall onset and leading to varying adaptation practices. The study concluded that gender plays a significant role in the adoption of adaptation practices in the agricultural sector and that males often have more access to resources and decision-making power in farming as the heads of households. There is a need for better gender-sensitive approaches to adaptation planning and implementation to ensure that both men and women have equal opportunities to benefit from adaptation options in agriculture.
Dynamic variation of the dielectric permittivity of elastomers with mechanical constraints
Authors: Jia Pan , Zheng Xianghe , Zhou Jianyou
Published: December 2023

Elastomers are commonly used as insulators or actuators in important fields such as robotics and electronics. The performance of elastomers is strongly influenced by their dielectric permittivity while determining the dielectric permittivity of elastomers appears to be rather challenging. With image processing techniques and a motor-driven biaxial test setup, the dynamic variation of the dielectric permittivity and dielectric loss of elastomers under dynamic mechanical constraints is first examined in this paper. Also, the mechanical rate-dependence and the cyclic behavior of the dielectric permittivity are investigated. At a given mechanical loading rate, the change in the dielectric permittivity is found to follow a cubic polynomial function. The variations of the stress and the dielectric permittivity indicate the mechanical constraints on the polarization of the material. Our experiment setup allows different mechanical loading paths to be applied to the elastomer when simultaneously measuring the dielectric permittivity and the dielectric loss.
Coarsening dynamics of ternary polymer solutions with mobility and viscosity contrasts
Authors: Garcia Jan Ulric , Tree Douglas R. , Bagoyo Alyssa , Iwama Tatsuhiro , Delaney Kris T. , Fredrickson Glenn H.
Published: December 2023

Using phase-field simulations, we investigate the bulk coarsening dynamics of ternary polymer solutions undergoing a glass transition for two models of phase separation: diffusion only and with hydrodynamics. The glass transition is incorporated in both models by imposing mobility and viscosity contrasts between the polymer-rich and polymer-poor phases of the evolving microstructure. For microstructures composed of polymer-poor clusters in a polymer-rich matrix, the mobility and viscosity contrasts significantly hinder coarsening, effectively leading to structural arrest. For microstructures composed of polymer-rich clusters in a polymer-poor matrix, the mobility and viscosity contrasts do not impede domain growth; rather, they change the transient concentration of the polymer-rich phase, altering the shape of the discrete domains. This effect introduces several complexities to the coarsening process, including percolation inversion of the polymer-rich and polymer-poor phases—a phenomenon normally attributed to viscoelastic phase separation.