bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS PEMILIHAN ALTERNATIF PENANGANAN KERUSAKAN JALAN
Authors: Andika Putra Reno Ferizqo , Mudiyono Rachmat , Adi Henny Pratiwi
Published: June 2023

Jalan sebagai sistem transportasi mempunyai peranan penting dalam mendukung bidang ekonomi, sosial dan budaya. Pada ruas jalan weleri-patean beberapa sudah mengalami kerusakan yang signifikan, sebagian ruas jalan belum mencapai masa umur rencana tetapi sudah mengalami kerusakan. Penelitian ini memiliki tujuan untuk mengidentifikasi apa saja jenis kerusakan jalan, kriteria dalam penanganan kerusakan jalan, dan alternatif untuk penanganan kerusakan jalan di ruas jalan Weleri-Patean. Metode Pengumpulan data pada penelitian ini dilakukan dengan wawancara dan pengisian kuisioner langsung responden. Penelitian ini mempunyai variabel yaitu kriteria (Jenis Kerusakan Jalan, Biaya Pelaksanaan, Waktu Pelaksanaan, Umur Rencana, Lalu Lintas Harian) dan alternatif (Perkerasan beton / kaku (rigid pavement), Metode Perkerasan Aspal / lentur (flexibel pavement), dan Metode Daur Ulang (Recycling). Metode analisis data dalam penelitian ini menggunakan metode Analitycal Hierarchy Process (AHP) dengan bantuan software Expert Choice 11. Hasil pada penelitian ini untuk prioritas kriteria didapat jenis kerusakan jalan dengan bobot (0,268), biaya pelaksanaan dengan bobot (0,097), waktu pelaksanaan dengan bobot (0,051), umur rencana dengan bobot (0,420), dan lalu lintas harian dengan bobot (0,163). Kemudian untuk prioritas alternatif didapat pada peringkat pertama adalah perkerasan kaku (0,562), kedua yaitu perkerasan lentur (0,329), dan ketiga yaitu metode daur ulang (0,109).
EFFECTS OF WEB-BASED ACADEMIC INFORMATION SYSTEM ON STUDENT SATISFACTION
Authors: Wijaya Reni , Yadewani Dorris , Hamdi Khairil
Published: June 2023

Tujuan penelitian yang dilakukan di kampus AMIK Jayanusa adalah untuk mengetahui pengaruh variabel Usability, Information Quality, Interaction Quality baik secara parsial maupun simultan terhadap kepuasan mahasiswa di AMIK Jayanusa Padang. Metode analisis yang digunakan dalam penelitian ini adalah analisis regresi linier berganda. Sampel penelitian ini adalah 57 siswa AMIK jayanusa Padang. Hasil penelitian ini menunjukkan bahwa variabel Usability Quality, Information Quality, Interaction Quality berpengaruh secara simultan terhadap kepuasan mahasiswa di AMIK Jayanusa dalam memanfaatkan sistem informasi akademik berbasis web. Secara parsial kualitas Usability memiliki pengaruh paling dominan terhadap kepuasan mahasiswa Jayanusa dalam memanfaatkan sistem informasi berbasis web.
FAKTOR PENGHAMBAT PENERAPAN GOOD MANUFACTURING PRACTICES (GMP) DENGAN HAZARD ANALYSIS AND CRITICAL CONTROL POINTS (HACCP) DI IKM MAMAK ANIK KABUPATEN OKU SELATAN
Authors: Wahyudi Diky , Kusmindari Ch. Desi
Published: June 2023

Abstrak: Penelitian ini bertujuan untuk mengetahui faktor-faktor apa saja yang menghambat penerapan Good Manufacturing Practices (GMP) dan Hazard Analysis And Critical Control Points (HACCP) di IKM Mamak Anik Kabupaten OKU Selatan. Sumber data berupa Data primer diperoleh dari kuesioner yaitu mengumpulkan data dari IKM Mamak Anik OKU Selatan dengan menggunakan daftar pernyataan yang telah dipersiapkan. Hasil penelitiannya menunjukkannn faktor-faktor yang menghambat penerapan Good Manufacturing Practices (GMP) dengan Hazard Analysis And Critical Control Points (HACCP) di IKM Mamak Anik Kabupaten OKU Selatan adalah dalam segi pembiayaan atau dana. Berdasarkan penilaian daftar periksa Good Manufacturing Practices (GMP) pada IKM Mamak Anik Kabupaten OKU Selatan terdapat 9 kriteria masuk dalam kategori prioritas dan 5 kriteria masuk dalam kategori tidak prioritas. Berdasarkan hasil proses identifikasi Hazard Analysis And Critical Control Points (HACCP) pada IKM Mamak Anik Kabupaten OKU Selatan terdapat 10 tahapan proses dalam pembuatan kopi bubuk IKM Mamak Anik Kabupaten OKU Selatan dan dari 10 tahapan. Kata kunci: GMP, HACCP, IKM
ANALISIS KELAYAKAN INVESTASI PADA PERUMAHAN DADAPAN IKA RESIDENCE SEMARANG
Authors: Putri Naftalia Paramita , Soedarsono Soedarsono , Sumirin Sumirin
Published: June 2023

Kebutuhan dan keinginan manusia dalam ekonomi konvensional diukur melalui tingkat kepuasan (utilitas) dalam mengkonsumsi atau memiliki barang/jasa. Oleh karena itu setiap warga negara berhak untuk bertempat tinggal dan mendapat lingkungan hidup yang baik dan sehat. Namun kenyataan yang terjadi sekarang ini belum sepenuhnya hak dasar warga negara tersebut terpenuhi. Banyak faktor yang mempengaruhi \di antaranya pemerintah yang berkewajiban dalam menyediakan perumahan layak dan terjangkau memiliki keterbatasan dalam hal pendanaan pembangunan perumahan. Untuk menanggulangi hal tersebut, pemerintah mendorong pihak swasta untuk menanamkan investasi di bidang properti terutama sektor perumahan. Investasi yang dilakukan oleh pihak swasta secara umum berorientasi untuk mendapatkan keuntungan sehingga sebelum menanamkan investasi memerlukan jaminan bahwa proyek akan memberikan keuntungan yang diharapkan. Untuk mengetahuinya maka peran penting studi kelayakan aspek keuangan mutlak dilakukan. Penulis mengambil penelitian dengan judul “Analisis Kelayakan Investasi Proyek Perumahan Dadapan IKA Residence Semarang”, dengan hasil perhitungan biaya pada Pembangunan Perumahan Dadapan IKA Residence di Sendangmulyo, Kecamatan Tembalang sebesar Rp17.617.115.875. Dari hasil penelitian bahwa proyek pembangunan perumahan Dadapan IKA Residence layak dan menguntungkan untuk dilaksanakan dengan NPV (Net Present Value) memberikan nilai positif sebesar Rp951.115.432, IRR (Internal Rate of Return) sebesar 12% lebih besar dari pada tingkat pengembalian yang diinginkan (IRR > 10%), PI (Profitability Index) sebesar 2,879 dan lebih besar dari yang disyaratkan yaitu PI > 1, Nilai BCR (Benefit Cost Ratio) sebesar 1,06 lebih besar dari syarat BCR yang disyaratkan (BCR > 1), BEP (Break Event Poin) pada penjualan unit rumah yang ke-24, serta nilai ISM menunjukkan angka positif yaitu Rp998.652.125.
PERENCANAAN LIFTING HOOK PILE CAP PRACETAK DERMAGA PELABUHAN BENOA BALI
Authors: Hapsari Rahma Nindya Ayu , Nugroho Budiono Joko
Published: June 2023

Dalam pembangunan infrastuktur, pilecap merupakan struktur yang digunakan untuk mentransfer beban dari kolom menuju pondasi. Bahan yang digunakan untuk struktur pile cap adalah beton bertulang pracetak. Pada struktur beton pracetak diperlukan tulangan lifting hook untuk dikaitkan pada hooke crane. Pada tulangan lifting hook menerima tahanan nominal tarik leleh, yang mana tahanan nominal yang diterima harus lebih kecil daripada tahanan ultimate. Pada penelitian ini menggunakan metode analisis SNI 03-1729-2002, dan analisis permodelan dengan software ANSYS. Untuk permodelan lifting hook, material yang digunakan adalah structural steel dengan diameter D13. Sedangkan untuk permodelan beban yang digunakan adalah beban dari berat sendiri beton precast. Beban dibagi dengan titik tulangan lifting yang akan dipasang. Menghasilkan tahanan nominal lebih besar dari pada tahanan ultimate (ɸTn>Tu ). Dengan tahanan nominal besi D13 4871,382 kg dan tahanan ultimate P1 =3144,05 kg, 571,435 kg, dan P3&P4 = 362,6 kg. Sehingga dapat dinyatakan bahwa tulangan hook yang digunakan mampu menahan tahanan nominal gaya tarik leleh terhadap tahanan ultimate.

Keywords: Pilecap, Lifting Hook, Beban
PENGARUH CAMPURAN AMPAS TEBU TERHADAP NILAI CBR PADA TANAH LANAU DI KECAMATAN PAYAKUMBUH BARAT
Authors: Khatab Umar , Asnur Hanifah , Yunita Rini
Published: June 2023

Kondisi Tanah Di Kota Payakumbuh khususnya kecamatan Payakumbuh Barat merupakan jenis tanah Lanau. Untuk itu perlu dilakukan perbaikan kondisi tanah agar dapat mendukung terhadap pembangunan infrastruktur di atasnya agar tidak terjadi gagal konstruksi, salah satunya yaitu dengan meningkatkan nilai CBR tanah lanau dengan penambahan ampas tebu. Metode yang digunakan dalam penelitian ini adalah eksperimental yaitu dengan penambahan variasi bahan tambah sebesar 2%, 4%, 6%, dan 8% dari berat tanah kering oven. Hasil penelitinan diperoleh terjadi peningkatan Nilai CBR dengan pencampuran abu ampas tebu pada semua variasi campuran dengan peningkatan terbesar terjadi pada variasi campuran 6% dimana nilai CBR tanah asli sebesar 2,94% meningkat menjadi 7,39%. Namun pada saat penambahan ampas tebu sebesar 8%, nilai CBR tanah Kembali menurun, namun nilai CBR lebih tinggi dari nilai CBR tanah asli. Artinya penambahan ampas tebu meningkatkan nilai CBR asli tanah lanau Kata Kunci: Tanah Lanau, CBR, ampas tebu
ANALISIS FAKTOR DOMINAN TERHADAP KEGAGALAN MEMENANGKAN TENDER PROYEK KONSTRUKSI
Authors: Sugiyanto Sugiyanto
Published: June 2023

Penelitian ini bertujuan untuk menganalisis faktor berpengaruh pada kegagalan memenangkan tender dengan pendekatan manajemen risiko. Data  dikumpulkan dari 75 perusahaan konstruksi tingkat nasional untuk terlibat dalam penilaian risiko terjadinya kegagalan didasarkan pada kriteria nilai keparahan,  keterjadian  dan deteksi. Faktor dominan ditinjau dari dokumen tender dan estimasi. Metode failure mode and effect analysis (FMEA) digunakan untuk identifikasi faktor dominan risiko tertinggi. Hasil penelitian menujukkan: Pada dokumen tender dapat diidentifikasi berdasarkan: Faktor desain dasar, sifatnya kritis dan menjadi prioritas untuk dilakukan perbaikan segera: terjadi pada peristiwa kurang sesuainya dengan lingkup   kerja, design kurang mendetail, minimnya detailnya scope of   work dan schedule pelaksanaan dari owner kurang realistis. Faktor lingkup kerja, sifatnya kritis dan menjadi prioritas untuk dilakukan perbaikan segera: terjadi pada peristiwa batas-batas lingkup kerja yang kurang jelas dalam hal material. Faktor jadwal, sifatnya kritis dan menjadi prioritas untuk dilakukan perbaikan segera: terjadi pada peristiwa kurang akuratnya perhitungan serta kurangnya kompetensi dan   pengalaman dari owner. Pada estimasi dapat diidentifikasi berdasarkan: Faktor sumber daya manusia, sifatnya kritis dan menjadi prioritas untuk dilakukan perbaikan segera; terjadi pada peristiwa kesalahan estimasi, estimasi kurang kompetitif dan  cenderung underprice, nilai tender menjadi overprice atau underprice,  dan kurangnya kemampuan  marketing
ANALISA PENGARUH KETIDAKSEIMBANGAN SUDUT FASA PADA MOTOR INDUKSI 3 FASA MENGGUNAKAN MATLAB
Authors: Hafis Zadil , Erhaneli Erhaneli , Anugrah Anggun , Bandri Sapannur
Published: June 2023

Ketidakseimbangan sudut fasa akan mempengaruhi motor induksi . Pada kondisi ini dapat menyebabkan kecelakaan pada motor induksi yang membuat mesin menjadi cepat panas, sehingga mengurangi kekuatan dan kemampuan motor tersebut. Definisi ketidakseimbang ditentukan berdasarkan metode NEMA. Simulasi dengan Matlab Simulink dilakukan untuk menganalisis dampak sudut fasa seimbang pada motor induksi 3 fasa dengan ketidakseimbangan 5%, dimana Phase A= 6o, Phase B = 120o, dan Phase = 240o. Pada saat sudut fasa tidak seimbang terjadinya perbedaan signifikan terhadap gelombang torsi dan kecepatan motor, dimana grafik  torsi dan kecepatan motor mengalami osilasi yang mengakibatkan getaran pada motor semakin besar. Ketidakseimbangan sudut fasa menyebabkan peningkatan nilai torsi dan kecepatan motor. Pada tanpa beban torsi bernilai 660 Nm dan kecepatan bernilai 1501 Rpm.  Sehingga dengan semakin naiknya nilai beban maka nilai torsi akan meningkat dan nilai pada kecepatan akan menurun. NEMA membuat motor dapat beroperasi secara normal spesifikasinya jika unbalace voltage tidak lebih dari 1%. Ketika ketidakseimbangan sudut fasa adalah 5% akan menyebabkan panas berlebihan dan kerugian pada motor meningkat. Untuk mengatasi ketidakseimbangan sudut fasa dengan cara dereating atau menurunkan peringkat motor. Ketika sudut fasa melebihi 1% maka motor harus melambat agar motor dapat berjalan dengan baik
PERANCANGAN SISTEM KELISTRIKAN PADA MESIN PERONTOK PADI BERTENAGA LISTRIK
Authors: Apfissetra Aldy , Anugrah Anggun
Published: June 2023

Padi merupakan salah satu komoditas pertanian yang sangat penting dan menjadi makanan pokok di Indonesia. Di Indonesia, petani mengolah hasil panen padi dengan cara merontokkan padi menggunakan alat tradisional dan konvensional. Tujuan dari penelitian ini adalah untuk membuat mesin perontok padi bertenaga listrik baterai, mengetahui komsumsi daya mesin dan waktu pengoperasian dengan memvariasikan kecepatan putaran perontok padi untuk kapasitas gabah yang sama dan kapasitas berat 1 kilogram padi. Metode penelitian dilakukan beberapa tahapan seperti perancangan dan perakitan mesin perontok padi, perancangan sistem kelistrikan dan perakitan serta pengujian mesin perontok padi. Dengan menghadirkan sebuah alat perontok padi tanpa bahan bakar maka perlu dilakukan perancangan mesin perontok padi menggunakan motor listrik DC 300 watt, arus 12,5 ampere, tenaga penggerak 1,04 Nm, dan memiliki kecepatan maxsimal 2750 rpm dengan baterai 24 volt 70 Ah sebagai catu dayanya. Hasil pengujian menunjukkan bahwa mesin dapat bekerja dengan baik dengan kecepatan yang dapat divariasikan sesuai kebutuhan dengan konsumsi daya maxsimal 25,31 watt. Pada pengujian 1 karung dengan kecepatan 1250 rpm, berat padi 5 kg dengan waktu pengoperasian 5,06 menit. Pada pengujian 1 Kg padi dengan kecepatan 1250 rpm, berat padi 350 gram, dengan waktu pengoperasian selama 18 detik. Mesin ini juga ramah lingkungan karena tidak ada emisi gas buang dan bersifat portable (dapat dipindahkan) ke lokasi yang diinginkan.
ANALISA PENGARUH KETIDAKSEIMBANGAN TEGANGAN MOTOR INDUKSI 3 FASA MENGGUNAKAN MATLAB SIMULINK
Authors: Kamal Aidil , Bandri Seppanur
Published: June 2023

Tegangan yang tidak seimbang akan mempengaruhi stator, torsi dan kecepatan motor. Pada kondisi ini dapat menyebabkan kecelakaan pada motor induksi 3 fasa yang membuat mesin menjadi cepat panas, sehingga menurunkan produktivitas mesin yang sebenarnya. Penyimpangan ketidakseimbangan tegangan ini akan menpengaruhi kinerja motor induksi yang dapat mengurangi kekuatan dan kemampuan motor tersebut. Definisi ketidakseimbang ditentukan berdasarkan metode NEMA (National Equipment Manufacturer’s Association). Simulasi perhitungan dengan Matlab Simulink dilakukan untuk analisis dampak ketidakseimbangan tegangan pada motor induksi 3 fasa dengan ketidak seimbangan 5%, dimana input tegangan yang diberikan pada Phase A= 420 Volt , Phase B = 400 Volt, dan Phase = 380 Volt. Pada saat tegangan tidak seimbang terjadinya perbedaan arus pada stator, gelombang torsi dan kecepatan motor, dimana ketika motor diberikan tegangan tidak seimbang menyebabkan arus pada stator menjadi tidak seimbang,  pada torsi dan kecepatan motor mengalami osilasi yang mengakibatkan getaran pada motor semakin besar. Tegangan tidak seimbang menyebabkan peningkatan nilai torsi dan kecepatan motor. Pada saat motor tanpa beban dengan input tegangan tidak seimbang torsi motor bernilai 574 Nm dan kecepatan motor saat stady state 1501 Rpm, dan pada beban 360 Nm nilai torsi motor saat stady state 934 Nm, dengan kecepatan motor 1497 Rpm, Sehingga dengan semakin naiknya nilai beban maka nilai torsi akan meningkat dan pada kecepatan motor akan menurun. NEMA membuat motor dapat beroperasi secara normal spesifikasinya jika unbalace voltage tidak lebih dari 1%. Ketika tegangan tidak seimbang 5% akan menyebabkan panas berlebih dan kerugian pada motor meningkat. Untuk mengatasi ketidak seimbangan tegangan dengan cara dereating atau menurunkan peringkat motor. Ketika tegangan tidak seimbang melebihi 1% maka motor harus melambat agar motor dapat berjalan dengan baik.
PERANCANGAN TUNGKU RE-HEATING PORTABLE
Authors: Putra Ranggi Efnal , Armila Armila , Arief Rudi Kurniawan
Published: June 2023

Re-heating furnace is a furnace that is used as a metal heater in the forging process. Re-heating furnace is one of the needs of the material technology laboratory to carry out the practical process of metal forming with plastic deformation as a heating medium for the forging process. The manufacture of this re-heating furnace is to make tools using medium carbon metal with a target temperature of 800℃. The process of making the furnace uses K300 type concrete material, 8mm reinforcing steel so that the furnace can be strong and durable. The furnace manufacture has succeeded in reaching a temperature of 302.8°C in 10 seconds using an air velocity of 15.4 km/h, and reaching a temperature of 931.8°C in 100 seconds using an air velocity of 25.7 km/h. This Re-heating Furnace can heat low-high carbon steel for forging process.
PERANCANGAN SISTEM INFORMASI PEMETAAN WILAYAH AIR BAKU KOTA TASIKMALAYA (SIPWARKOT) PADA UPTD PSDA WILAYAH SUNGAI CIWULAN-CILAKI
Authors: Mulyani Yani Sri , Alawiyah Tuti , Rivalda Muhamad
Published: June 2023

Geographic information systems or GIS are information systems related to geographical features and are used to manipulate and display information in a geographical area. GIS can also be used for mapping, particularly in raw water areas. At the UPTD PSDA Ciwulan-Cilaki River Area, there are problems in managing data on applications for the submission of raw water requests carried out by the community. The applicant was required to send a letter requesting the submission of raw water to the agency, which resulted in the piling up of letters in the archives. Another problem found is that the survey process feels very long and takes days. This aimed of this researched was to design a geographic information system to solve the problem. In this research, the researchers designed a geographic information system mapping the raw water area of Tasikmalaya City based on Android using the Prototype method. The stages in the Prototype method are Communication, Planning, Representation, and Construction. The benefits and results of this information system design were that it made it easier for applicants to apply for raw water along with mapping the raw water area and for application management agencies to be more structured. In addition, this android-based GIS could be accessed by applicants and agencies anytime and anywhere.
Endometrial polyps: state of the problem and prediction
Authors:   Kazan State Medical University, GABIDULLINA R. I. , SMIRNOVA G. A. ,   Kazan State Medical University, ZARIPOVA A. SH. ,   Kazan State Medical University, VALEEVA E. V. ,   Kazan State Medical University, SHIGABUTDINOVA T. N. ,   City Clinical Hospital No. 7, SIRMATOVA L. I. ,   City Clinical Hospital No. 7
Published: June 2023

The purpose — to study the current state of the problem of endometrial polyps, to analyze the prevalence of alleles and genotypes of the rs11841589 polymorphism of the KLF12 gene and their association with the risk of endometrial polyps and endometrial cancer in women. Material and methods. The article presents an overview of publications based on search results in the electronic resources PubMed, Elibrary, EMBASE and Google Scholar. The study included 247 women living in the Republic of Tatarstan: 86 with endometrial polyps (PE), 60 with endometrial cancer (RE), 101 patients without pathological changes in the endometrium. Clinical and laboratory examination, genotyping of the polymorphism rs11841589 of the KLF12 gene, pathomorphological examination of the endometrium were carried out. The biomaterial for genotyping the polymorphism rs11841589 of the KLF12 gene was DNA from whole blood (TestGen, Ulyanovsk). A set of reagents «Rapid-Genetics Test» by DNA-Technology LLC (Moscow, Russia) was used. The study was carried out within the framework of KSMU research No. 122082300042-2 in compliance with the principles and conditions of the Helsinki Declaration. Results. Endometrial polyps, due to their prevalence, high frequency of abnormal uterine bleeding and the risk of malignancy, represent one of the most serious gynecological problems worldwide. The mutant allele with the rs11841589 polymorphism of the KLF12 gene and the CC genotype, according to the study, do not significantly increase the risk of developing endometrial polyps and endometrial cancer in women living in the Republic of Tatarstan. It is proved that the prevalence of alleles and genotypes is comparable to the European population. Conclusion. This study showed that 247 residents of the Republic of Tatarstan included in the study had no association of rs11841589 polymorphism of the KLF12 gene with the risk of developing endometrial polyps and endometrial cancer.
Neuron-specific enolase of liquor as an objective marker of cognitive impairments in HIV-associated encephalopathy
Authors:   Perm State Medical University named after Academician E. A. Wagner, KARAKULOVA YU. V. , SEKSYAEV N. E. ,   Perm State Medical University named after Academician E. A. Wagner, SOSNIN D. YU. ,   Perm State Medical University named after Academician E. A. Wagner
Published: June 2023

One of the main causes of cognitive dysfunction in a late stage of HIV infection is HIV-associated encephalopathy. The direct neurotropic impact of HIV creates the pathogenic basis for this clinical syndrome. The purpose — to evaluate the cognitive status and neuron-specific enolase (NSE) level in cerebrospinal fluid (CSF) in HIV-encephalopathy patients. Material and methods. 35 patients were included in the study. They were divided into two groups: 20 patients (9 females and 11 males) with cognitive dysfunction and confirmed diagnosis of HIV/AIDS and 15 patients (6 females and 9 males) were in comparison group. The cognitive status was investigated by mini-mental state examination (MMSE), international HIV-dementia scale (IHDS) and frontal assessment battery (FAB). CSF level of NSE were investigated by ELISA test. Results. Correlation between cognitive dysfunction severity and NSE level in CSF was determined in HIV-encephalopathy patients. Conclusion. NSE level changing in CSF is an objective indicator of clinical severity of HIV-encephalopathy and neurotropic impact of HIV.
Clinical-epidemiological and laboratory characteristics of a food salmonellosis outbreak
Authors:   Kazan State Medical University, NIKOLAEVA I. V. , TKACHEVA S. V. ,   Kazan State Medical University, FAZULZYANOVA A. I. ,   Kazan State Medical University, LATFULLINA E. Z. ,   Kazan State Medical University, RAKHMANOVA O. A. ,   Republic Infectious Clinical Hospital named after Prof. A.F. Agafonov, BELOVA M. N. ,   Republic Infectious Clinical Hospital named after Prof. A.F. Agafonov
Published: June 2023

Among bacterial intestinal infections, salmonellosis occupies one of the leading places. The purpose to study the clinical, epidemiological and laboratory features of a food outbreak of salmonellosis. Material and methods. A retrospective analysis of 29 medical records of patients from a food outbreak of salmonellosis hospitalized in the Republican Clinical Infectious Diseases Hospital of Kazan in September 2021. Results. The likely transmission factors for Salmonellosis were poached egg and/or lightly salted salmon. Young females predominated (83%) among patients. The disease proceeded according to the gastroenteric variant (69%) of moderate severity (96.6%) with a favorable outcome (100%). The incidence of colitis syndrome was 31%. Among the biochemical parameters, high levels of CRP (161.97 (108.54) mg/l) attracted attention, reaching values characteristic of a severe bacterial infection. In bacteriological examination of faeces and/or vomit, Salmonella enteritidis was isolated from all patients. The isolated strains of S. enteritidis were sensitive to ampicillin, cefepime, ceftriaxone, chloramphenicol, salmonella bacteriophage, 80% of the isolates were resistant to pefloxacin and 40% to co-trimoxazole. Conclusions. A persistent increase in CRP can be used at the initial stage of differential diagnosis of etiologically different types of diarrheas to decide on the tactics of treating patients with infectious diarrhea. In order to maximize the effectiveness of antimicrobial treatment of salmonellosis, it is necessary to focus on regional antibiotic susceptibility profiles.
Acute coronary syndrome in patients with aortic valve stenosis
Authors:   Moscow Regional Ambulance Facility, MUKANOVA M. B. , KOPYLOV F. YU. ,   I.M. Sechenov First Moscow State Medical University, KOMAROV R. N. ,   I.M. Sechenov First Moscow State Medical University, SEREBRENNIKOV I. I. ,   Moscow Regional Ambulance Facility, GAFUROV F. S. ,   Egoryevsk Central Regional Hospital, KHUZIAKHMEDOV A. N. ,   I.M. Sechenov First Moscow State Medical University, BABAKULOVA N. M. ,   I.M. Sechenov First Moscow State Medical University, ISMAILBAEV A. M. ,   I.M. Sechenov First Moscow State Medical University
Published: June 2023

The purpose — to assess the acute coronary syndrome (ACS) clinical aspects in patients with aortic stenosis. Material and methods. This is a retrospective single-center study that included comparison of hospital and midterm outcomes of ACS and aortic stenosis (n = 95, divided into the following groups: group 1 — severe aortic stenosis + ACS (n = 39); group 2 — moderate aortic stenosis + ACS (n = 28); group 3 — ACS without aortic stenosis (the control group selected using «Propensity matching» method) (n = 28)). Results. Hospital mortality did not differ statistically between the groups. In group 1, there was a tendency to worse survival within 1 year. In groups with aortic malformation, ACS with ST segment elevation was less common — p = 0.0002 and p = 0.001, respectively. In group 1, 23.1% of patients had intact coronary arteries. Conclusions. Severe aortic valve stenosis in some cases «mimics» acute coronary syndrome, which is indicated by significantly more frequent detection of intact coronary arteries in this cohort. Aortic stenosis of varying degrees does not lead to an increase in the frequency of early postoperative complications and 30-day mortality after PCI.
Nutritional approaches used in the complex therapy of children with autism spectrum disorder
Authors:   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, BELOUSOVA M. V. , MOROZOVA E. A. ,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia, GOMSINA E. G. ,   Kazan State Medical Academy — Branch Campus of the FSBEI FPE RMACPE MOH Russia
Published: June 2023

The article discusses the modern scientific data demonstrating the influence of intrauterine and early postnatal macro- and microelement deficiency on fetal neurogenesis and further cognitive development of the child. The features of the development of children with autism spectrum disorder (ASD) are given, including the formation of eating behavior, manifestations of selectivity in food within the framework of sensory disintegration, self-restriction of the diet due to «novelty avoidance». Nutritional disorders in children with ASD, observed from an early age, are often accompanied, or cause the manifestation of gastroenterological disorders that require timely treatment, including diet therapy. The feeding difficulties faced by the family of a child with ASD often push parents to self-treat with various diets, the balance and effectiveness of which are often very questionable. The article discusses the positive effects of diets prescribed and controlled by nutritionists and discusses the risks of self-treatment. The authors emphasize the necessity of correcting eating disorders in children with ASD and the importance of a gastroenterologist and nutritionist participation in the interdisciplinary complex support of children with ASD.
Long-term consequences of COVID-19 in patients with inflammatory intestine diseases (by the data of functional-radiology examinations of lungs and EchoKG)
Authors:   Kazan State Medical University, KUPKENOVA L. M. , ABDULGANIEVA D. I. ,   Kazan State Medical University, SHAMSUTDINOVA N. G. ,   Kazan State Medical University, ODINTSOVA A. KH. ,   Republic Clinical Hospital, ISKHAKOVA D. G. ,   City Clinical Hospital No. 7, CHERKASHINA M. I. ,   Republic Clinical Hospital, CHEREMINA N. A. ,   Republic Clinical Hospital
Published: June 2023

The purpose — to assess the presence and course of post-COVID syndrome, damage to the lungs and cardiovascular system, as well as the course of IBD in the post-COVID period. Material and methods. The study included 36 patients diagnosed with Crohn’s disease (CD) and ulcerative colitis (UC) who had COVID-19 with lung damage. To identify the clinical symptoms characteristic of the post-COVID syndrome, we used a questionnaire as part of an in-depth medical examination for citizens who had had COVID-19 3, 6, 9 and 12 months before. All patients, 12 months after having COVID-19, underwent an assessment of the respiratory function (RF), echocardiography, and X-ray computed tomography of the chest organs (CT scan of the chest). Results. Complaints characteristic of post-COVID syndrome occurred more often and longer in patients with respiratory distress (RD). When assessing the respiratory function and echocardiography, minor changes were detected; in the group of patients with RD, the changes were more pronounced. When analyzing the parameters of the CT scan of the chest after 12 months, changes were detected only in the group of patients with RD during COVID-19. The maximum number of patients in exacerbation of IBD was noted 3-6 months after COVID-19. Conclusions. According to the results of the questionnaire used as part of the in-depth medical examination of patients after COVID-19, respiratory function, echocardiography, CT scan, it was found that the post-COVID syndrome was more severe and lasted longer in patients with lung damage and RD during COVID-19.
Large functioning Childhood adrenocortical carcinoma (Case report)
Authors: Jabbar Jinan A. , Fahad Qusai A.
Published: June 2023

We describe a large functioning non metastasizing ACC in 8 years old boy who presented with a history of precocious puberty noticed by his parents since 3 months .Ultrasound of the abdomen showed a large well defined right suprarenal mass with calcification and necrosis . MRI  showed  the mass to be hypojntense to liver on T1 and   hyperintense  to liver on T2, and  dynamic CT scan revealed a large hetrogenous  enhancing right suprarenal mass with calcification and necrosis , clear chest .Histopathology done after surgical removal reveal adrenocortical carcinoma,so we recommend to do an abdominal ultrasound to any child with precocious puberty because it is easy,cheap and non invasive , if any suprarenal mass found it should be further characterized by MRI and  dynamic conontrast enhanced CT to determine its respectability
Splenectomy for isolated splenomegaly; experience with twelve patients
Authors: Al Saffar Ahmed A . , Abbas Mohammed S. , Mohammed Mazin A.
Published: June 2023

Background: Changes in the indication for splenectomy in hematology, especially in hematological malignancies, has been observed in the last 10 – 15 years. Yet splenectomy, as a diagnostic tool, is still an option in the management of isolated splenomegaly.Objectives: to describe the outcome of diagnostic splenectomy in the management of 12 patients presenting with isolated splenomegaly.Patients and methods: Between August 2005 and July2012, Twelve patients underwent splenectomy for diagnostic purposes in the hematology unit / Baghdad Teaching Hospital. Analysis of these patients was done with a median follow up of 16 months (6 months -4 years).Results: The median age was 46 years (range 25-68). The median duration of symptoms was 6.8 months (range 3-12) months. The median duration of follow up was 16 months. We had 8 females, and 4 males. Three patients were asymptomatic, but they had progressive enlargement of spleen over one month. The most common symptoms were malaise and abdominal pain, seen in 8 patients. The other less frequent symptoms were fever (5 patients), weight loss (5 patients), arthralgia (4 patients), while the bleeding manifestation was seen in one patient only. Anemia was seen in 5 patients, two had leucopenia, and two had thrombocytopenia. Focal lesions in the spleen were seen in two patients by ultrasound and CT scan. The results of bone marrow aspirate and biopsy, upper gastrointestinal endoscopy and serological tests for collagen vascular diseases all were unrevealing prior to splenectomy. The histopathological results were; Hodgkin disease(1 patient), intermediate grade Non-Hodgkin lymphoma(1 patient) , splenic marginal zone NHL(2 patients),Diffuse Large B Cell Lymphoma(1 patient), Gaucher's disease(1 patient), favor myeloproliferative disorders(1 patients), one patient had tuberculosis, while 4 patients ended with non-diagnostic results. Laproscopic splenectomy was done in one patient only. Postoperative complications were seen in 4 patients which were grade 1-2 bleeding and simple wound infection. During follow up one patient with undiagnostic reports proved to have collagen vascular disease & two patients developed lymphoma, and the last one developed features of myeloproliferative disorder.Conclusion: splenectomy for isolated splenomegaly has a significant impact on the management of a significant proportion of those 12 patients. Other investigations which help in the diagnosis of collagen vascular diseases, myeloproliferative disorders& lymphoproliferative disorders are needed before proceeding for splenectomy.
KUTBEDDİN İZNİKÎ’NİN MUKADDİME’Sİ VE DÜRT- FİİLİNİN TÜRKÇENİN TARİHÎ METİNLERİNDEKİ SEMANTİK KATEGORİSİ
Authors: TEZCİ ÇAKIR Çağla , TAŞ İbrahim
Published: June 2023

Terim olarak ilmihâl, ‘inanç, ibadet, muamelat (günlük yaşayış), ahlak konuları, yer yer büyük peygamberler, ayrıca Hz. Muhammed’in hayatına dair özlü bilgileri içeren el kitabı’ anlamına gelir. İlmihâl geleneği ilk olarak halkın anlayacağı dilde, basit, sade anlatımlı, temel dinî konularda özlü bilgilere duyulan ihtiyaçtan dolayı 15.-16. yüzyıllarda Osmanlılarda ortaya çıkmıştır. Bu gelenek önce Arapça eserlerin Türkçeye tercümesi ve eksik görülen hususların eserlere eklenmesiyle başlamıştır. Bu türün Osmanlılardaki ilk örneği, adında “ilmihâl” sözcüğü geçmese de, Kutbeddin İznikî’nin Mukaddime’si kabul edilir.

İznikî’nin Mukaddime’sinin yerli ve yabancı kütüphanelerde olmak üzere sayısız nüshası bulunmaktadır. Eser bâb adı verilen beş bölümden ve bir girişten oluşmaktadır. Giriş bölümünde eserin yazarı, yazılış nedenleri, amacı ve konusu üzerinde durulur. İlk bölümde iman, imanın şartları, cennet-cehennem, sevap-günah gibi kavramlar çeşitli mezheplerin görüşleri aktarılarak anlatılır. İkinci bölümde namaz konusu ele alınmıştır. Üçüncü bölüm zekât, öşür, fitre, haraç, kurban, gömü ve sadaka hükümlerine ayrılmıştır. dördüncü bölüm oruca, beşinci bölüm de hac ve umre hükümlerine ayrılmıştır.

Mukaddime, kendi döneminde rağbet gördüğü ve pek çok nüshası bulunduğu için filolojik araştırmalara da konu edilmiştir. Bu çalışmalar incelendiğinde eserin, yer yer halkın anlayacağı dille ve sade bir anlatımla kaleme alındığı söylenebilir. Bunun yanında metnin gerek söz varlığı gerekse üslup olarak konuşma dilinden izler taşıdığı da görülmektedir. Söz varlığı açısından bakıldığında ise eserde, Türkiye Türkçesi ağızlarından tanıdığımız ancak dönem metinlerinde tesadüf etmediğimiz kehellik ėt- ‘üşenmek, tembellik etmek’ ya da seyrek olarak karşılaştığımız ḳovalt- ‘secdede iken karın ile uyluk arasını açmak’ gibi sözcüklere de rastlanmaktadır. Bu çalışmada konu ettiğimiz dürt- fiili ise metinde aynı pasajda üç kez geçmektedir ve ‘(kâfur vb. kokulu nesneler) sürmek’ anlamına gelmektedir. Eski Türkçe metinlerden itibaren sıklıkla karşılaştığımız ve özgün anlamı ‘(koku, kokulu maddeler, yağ vb.) sürmek’ olan dürt- (< türt-) fiili, Eski Türkçe (11. yüzyıla kadar) ve Orta Türkçe (12.-15. yüzyıl arası) metinleri tahlil edildiğinde farklı semantik dağılımlar sergilediği görülmektedir. İşte burada konu edilen çalışma, Kutbeddin İznikî’nin Mukaddime’sinde yer alan kesitten hareketle Eski Türkçe ve Orta Türkçe metinlerdeki pasajları irdeleyerek fiilin semantik kategorisini tespit etmeyi ve söz konusu kategorilerin temel anlamla olan ilişkilerini incelemeyi amaçlamaktadır.
Increased Cerebral Serum Amyloid A2 and Parameters of Oxidation in Arylsulfatase B (N-Acetylgalactosamine-4-Sulfatase)-Null Mice
Authors: Bhattacharyya Sumit , Tobacman Joanne K.
Published: June 2023

Background:

Chondroitin sulfate and chondroitin sulfate proteoglycans have been associated with Alzheimer’s disease (AD), and the impact of modified chondroitin sulfates is being investigated in several animal and cell-based models of AD. Published reports have shown the role of accumulation of chondroitin 4-sulfate and decline in Arylsulfatase B (ARSB; B-acetylgalactosamine-4-sulfatase) in other pathology, including nerve injury, traumatic brain injury, and spinal cord injury. However, the impact of ARSB deficiency on AD pathobiology has not been reported, although changes in ARSB were associated with AD in two prior reports. The enzyme ARSB removes 4-sulfate groups from the non-reducing end of chondroitin 4-sulfate and dermatan sulfate and is required for their degradation. When ARSB activity declines, these sulfated glycosaminoglycans accumulate, as in the inherited disorder Mucopolysaccharidosis VI.

Objective:

Reports about chondroitin sulfate, chondroitin sulfate proteoglycans, and chondroitin sulfatases in AD were reviewed.

Methods:

Measurements of SAA2, iNOS, lipid peroxidation, chondroitin sulfate proteoglycan 4 (CSPG4), and other parameters were performed in cortex and hippocampus from ARSB-null mice and controls by QRT-PCR, ELISA, and other standard assays.

Results:

SAA2 mRNA expression and protein, CSPG4 mRNA, chondroitin 4-sulfate, and iNOS were increased significantly in ARSB-null mice. Measures of lipid peroxidation and redox state were significantly modified.

Conclusion:

Findings indicate that decline in ARSB leads to changes in expression of parameters associated with AD in the hippocampus and cortex of the ARSB-deficient mouse. Further investigation of the impact of decline in ARSB on the development of AD may provide a new approach to prevent and treat AD.
Remembering Andrew Pleasant’s career and contributions
Authors: O’Leary Catina , Zarcadoolas Christina , Peres Frederico
Published: June 2023

This paper provides reflections on the career and contributions of Andrew Pleasant during his almost 30-year career in the health literacy field, from the perspectives of three of his close friends, Christina Zarcadoolas, Frederico Peres, and Catina O’Leary. As a health literacy professional, Andrew published 75 papers, nine chapters, and one book, becoming, over these years, very active from a local to an international level as a community researcher, university faculty member, and community organization leader. Across diverse settings, he wrote and shared his thoughts formally and informally to generate conversation about health literacy, science communication, environmental sciences, community engagement and public health, among many other topics. It was a labor of love for Andrew to communicate complex health and scientific information to people most in need of understanding information within the context of their lives, always reminding to those who had the privilege to share professional and personal experiences with him that we need to ask people, early and often, if we are getting it right and, when we are not, ask them how to do better. Accompanying his many written contributions to the field, Andrew’s legacy is his passion to appreciate, listen, and learn.
RAGE Against the Glycation Machine in Synucleinopathies: Time to Explore New Questions
Authors: Gelain Daniel Pens , Bittencourt Reykla Ramon , Bastos Mendes Luiz Filipe , Moreira José Claudio Fonseca , Outeiro Tiago Fleming
Published: June 2023

Oligomerization and aggregation of misfolded forms of α-synuclein are believed to be key molecular mechanisms in Parkinson’s disease (PD) and other synucleinopathies, so extensive research has attempted to understand these processes. Among diverse post-translational modifications that impact α-synuclein aggregation, glycation may take place at several lysine sites and modify α-synuclein oligomerization, toxicity, and clearance. The receptor for advanced glycation end products (RAGE) is considered a key regulator of chronic neuroinflammation through microglial activation in response to advanced glycation end products, such as carboxy-ethyl-lysine, or carboxy-methyl-lysine. The presence of RAGE in the midbrain of PD patients has been reported in the last decades and this receptor was proposed to have a role in sustaining PD neuroinflammation. However, different PD animal models demonstrated that RAGE is preferentially expressed in neurons and astrocytes, while recent evidence demonstrated that fibrillar, non-glycated α-synuclein binds to RAGE. Here, we summarize the available data on α-synuclein glycation and RAGE in the context of PD, and discuss about the questions yet to be answered that may increase our understanding of the molecular bases of PD and synucleinopathies.
MCDA - Groundwater prediction analysis for Sustainable Development using GIS Supported AHP in Okeigbo, Southwestern Nigeria
Authors: Olumuyiwa Falowo , Moses Philip Otuaga
Published: June 2023

Multi-criteria decision analysis with GIS-supported Analytical Hierarchy Process (AHP) has been undertaken in Okeigbo, Southwestern Nigeria to predict the hydrogeologic significance of the aquifers and in relation to the geologic units; quartzite, quartz schist, and metadiorite. Six parameters of higher hydrogeologic importance were pairwise and weighted respectively: AQT - aquifer layer thickness (0.07), AQR - aquifer layer resistivity (0.16), OVT - overburden thickness (0.10), TR - transverse resistance (0.20), TMY - transmissivity (0.26), CoA - coefficient of anisotropy (0.22). Subsequently, the GWPIV ranged from metadiorite 1.08 (weathered/fracture aquifer) – quartz schist 3.55 (weathered aquifer) with an average of 2.35 indicating moderate groundwater potential. The low, moderate, and high zones constituted 25 %, 55 %, and 20 % respectively of the study area. The high potential zone is prominent in the mid-central and north central parts. Conclusively, the quartz schist and quartzite areas showed better prolificacy than metadioritic environment. But in terms of protective capacity of the aquifers, the longitudinal unit conductance recorded weak regional average of 0.19396 mhos, with quartzite (0.33444 mhos) and quartz schist (0.15218 mhos); and metadiorite recorded 0.1208 mhos, hence metadiorite being the weakest environment. The water table aquifer and the fracture basement are the major water bearing units in the area. The drainage basin falls within the low – moderate regional drainage basins, with moderate to high flow connectivity and low – moderate flow direction. Thus there’s possibility of movement of water towards the northern part (discharged zone) with the southern area forming the watershed.
Основні теоретичні концепції та принципи системи дистанційного навчання
Authors: Зварич Данило
Published: June 2023

У цій статті висвітлюється проблематика реалізації теорій і принципів дистанційного навчання в Україні. При цьому на основі системного та синергетичного підходів, методів аналізу і синтезу, індукції та дедукції, історичного, компаративного і порівняльного аналізу встановлено, що трактування віддаленого здобуття знань в Україні та у Європі загалом аналогічні. Одночасно із цим динаміка економічних і соціальних процесів, які відбуваються у сучасному суспільстві та кардинальні зміни у способах використання і поширення інформації зумовлюють еволюцію освітніх технологій, сприяють активному впровадженню онлайннавчання як одного із основних напрямків реформування та стратегічного розвитку освітньої системи України. Водночас в умовах її модернізації особливої актуальності набувають інформаційні технології у системі методологічної діяльності. Висвітлено три групи теорій дистанційного навчання: автономії та незалежності; взаємодії та комунікації; індустріалізації навчання та тісно пов’язані з ними дидактичні принципи онлайн-освіти, аналіз яких показав, що їхніх класичних видів, які зазвичай використовуються у традиційному навчанні, для сучасної системи дистанційного отримання знань недостатньо, позаяк їй притаманні специфічні, властиві саме їй дидактичні принципи. Одночасно із цим є винятково актуальним зіставлення його теоретичних концепцій і принципів із практикою їх запровадження у вітчизняних умовах, що особливо важливо за інтеграційних устремлінь України у європейський, зокрема, Європейського Союзу, простір.
Діалектична єдність коучингу та цифрових технологій як запорука якісного навчання (на прикладі ВСП «Київський фаховий коледж міського господарства Таврійського національного університету ім. В. І. Вернадського»)
Authors: Сарнавська Людмила
Published: June 2023

Освіта, як одна з найважливіших складових суспільства, з одного боку, залежить від процесів, що відбуваються в ньому, повинна швидко реагувати та відповідати стану науково-технічного прогресу, тенденціям розвитку економічної сфери країни, з іншого, безумовно, – впливає на всі процеси і сторони життя, оскільки готує фахівців, розвиває особистість, формує певні життєві погляди. Тому особливої уваги заслуговує сучасний стан, проблеми впровадження та перспективи інновацій, зокрема цифрових технологій в освіту нашої країни. У статті аналізується особливості коучингових та цифрових технологій, які забезпечують краще засвоєння навчального матеріалу здобувачами освіти у сучасних умовах змішаного навчання. Студентоцентрований підхід стає головним вектором у формуванні інтегральних, загальних та спеціальних компетентностей, посилює роль здобувача фахової передвищої освіти як рівного учасника освітнього процесу – від пасивного слухача до активного, який може впливати на процес отримання знань, компетенцій і навичок, самостійно формулювати власні інтереси та потреби, забезпечуючи тим самим затребуваність на ринку праці, високу здатність до працевлаштування. Одним із методів реалізації студентоцентрованого підходу до викладання є застосування в практичному поєднанні коучингових технологій з різними Google-сервісами. Детально описані певні техніки коучингу, які викладачі ВСП «Київського фахового коледжу міського господарства Таврійського національного університету» застосовують у своїй педагогічній практиці.
Діагностика особливостей реалізації прикладної спрямованості шкільної природничої освіти
Authors: Мельник Юрій
Published: June 2023

У статті здійснено аналіз сучасного стану шкільної природничої освіти за резуль- татами опитування з використанням технології гугл-форм, яким охоплено понад 7 тисяч учите- лів закладів загальної середньої освіти. Висвітлено питання діагностики реалізації прикладної спрямованості у контексті вдосконалення змісту навчання та його дидактичного забезпечення, системи методів і прийомів, спрямованих на оптимізацію освітнього процесу, ефективного фор- мування ключових компетентностей. З’ясовано, що ключовим аспектом прикладної спрямованості сучасної шкільної природни- чої освіти є максимальна орієнтованість її змісту, методів, форм і засобів навчання на застосу- вання знань у техніці й технологіях, наукових дослідженнях і професійній діяльності людини та її повсякденному житті. Зроблено висновок, що посилення прикладної спрямованості шкільної природничої освіти може стати важливою дидактичною умовою формування в учнів ключових компетентностей. Встановлено, що важливим інструментом реалізації прикладної спрямованості природни- чої освіти є практико-орієнтовані дослідницькі завдання, як правило, міжпредметного змісту, розв’язування яких сприяє ґрунтовному засвоєнню здобувачами знаннями світу природи, умін- нями і навичками, усвідомленню практичного значення наукових теорій та їх впливу на розвиток техніки і технологій. Виконання завдань прикладного характеру сприяє як формуванню пред- метної компетентності з конкретного природничого предмету, так і ключової компетентності в галузі природничих наук, техніки та технологій. Обґрунтовано наявність значущих зв’язків між компетентнісним потенціалом змісту шкіль- ної природничої освіти та його прикладною спрямованістю, що є засобом установлення відпо- відності між змістовим та цільовим складниками природничої галузі, пріоритетом опанування якою є набуття учнями знань і вмінь, потрібних їм упродовж життя. Акцентовано увагу на проблемі реалізації дидактичних функцій навчального експерименту в умовах дистанційного навчання як інструменту посилення прикладної спрямованості шкільної природничої освіти.