bluuebunny/crossref_metadata_2025 huggingface dataset:
“Prevalence, Predictors and Outcomes of Surgical and Gastrointestinal Bleeding Events in Patients with COVID-19 Infection on Anticoagulation”
Authors: Alkhamis Ahmed , Alshamali Yousef , Alyaqout Khaled , Lari Eisa , Alkhamis Moh A. , Althuwaini Saad , Lari Ali , Alfili Maryam , Alkhayat Ali , Jamal Mohammad H , Alsabah Salman
Published: March 2021

BackgroundThis study aims to examine risk factors and complications associated with bleeding events in patients with coronavirus 19 (COVID-19) who are on anticoagulation. MethodWe conducted retrospective review of a prospectively maintained database of all patients who were admitted with COVID-19 and developed bleeding events. ResultsOf 122 bleeds, there were 67 (28%) non-gastrointestinal (GI) and 55 (28%) GI bleeds. Overall mortality was 59% (n= 72), 34 (28%) and 38 (31%) following non-GI and GI bleeds respectively. The prevalence of therapeutic invasive interventions was 7.5% and 16.3% in non-GI and GI bleeds respectively and all were successful in resolving the bleeding event. We found that having a GI bleeds was associated with higher risk of mortality compared to non-GI bleeds (p= 0.04) and having occult bleeds to be associated with 15 times increased risk of mortality. Furthermore, patients who were on therapeutic dose of anticoagulation were more likely to die compared to patients who were on none (odds ratio (OR) 0.1, 95%CI 0.01-0.86), on prophylactic (OR 0.07,95%CI 0.02-0.28) or intermediate (OR 0.36,95%CI 0.09-1.34) anticoagulation doses.Conclusions Routine prescription of supra-prophylactic dose anticoagulation should be revisited as it appears to be associated with increased of mortality and so more individualized approach to prescription should be the norm. Regardless of the cause of bleeding event it appears that the majority of bleeding events resolve with noninvasive interventions, correction and optimization sepsis therapies. However, when invasive interventions were necessary, they were associated with high success rate despite the delay.
Efficacy and Safety of Remdesivir in COVID-19 Patients: A Retrospective Analysis of Active Surveillance Database
Authors: Gupte Vaishali , Hegde Rashmi , Sawant Sandesh , Kalathingal Kabil , Jadhav Sonali , Malabade Rohit , Gogtay Jaideep
Published: March 2021

Background: Real-world data on safety and efficacy of remdesivir in COVID‑19 management is scant. We present findings of data analysis conducted for assessing the clinical outcomes of remdesivir treatment for COVID-19 in India. Methods: This retrospective analysis used data from an active surveillance programme database of hospitalised patients with COVID-19 who were receiving remdesivir. Results: Of the 2329 patients included, 67.4% were men. Diabetes (29.69%) and hypertension (20.33%) were the most common comorbidities. At remdesivir initiation, 2272 (97.55%) patients were receiving oxygen therapy. Remdesivir was administered for 5 days in 65.38% of patients. Antibiotics (64.9%) and steroids (47.9%) were the most common concomitant medications. Remdesivir was overall well tolerated: 13% of patients reported 119 adverse events; most common were nausea and vomiting in 45.4% and increased liver enzymes in 14.28% patients. 84% of patients were cured/improved, 6.02% died, and 9.16% showed no improvement in their clinical status at data collection. Subgroup analysis showed that the mortality rate was significantly lower in patients < 60 years old than in those > 60 years old. Amongst patients on oxygen therapy, the cure/improvement rate was significantly higher in those receiving standard low-flow oxygen than in those receiving mechanical ventilation, non-invasive ventilation, or high-flow oxygen. Risk factors for higher mortality were age > 60 years, hypertension, cardiac disease, diabetes, and mechanical ventilation. Conclusion: Our analysis showed that remdesivir is well tolerated and has an acceptable safety profile. The cure/improvement rate was 84%, with a higher improvement in patients < 60 years old and on standard low-flow oxygen.
Correlates of Non-Participation in Mass Drug Administration Against Neglected Tropical Diseases in the Assin North Municipality in the Central Region of Ghana
Authors: Akazili James , Agoringya Isaiah , Kanmiki Edmund Wedam , Woode Maame , Alomatu Bright , Osei-Atweneboa Mike , Thomson Rachael , Selormey Pamela , Khan Jahangir A. M.
Published: March 2021

Background: Many countries in Africa are making progress towards reducing the incidence of Neglected Tropical Diseases (NTDs) and possibly eliminating them completely. Through the accepted global strategy of Mass Drug Administration (MDA), the COUNTDOWN project1 has made significant attempts through a partnership with the Ghana Health Service to reduce the incidence and impact of NTDs particularly Schistosomiasis (SCH), Soil Transmitted Helminths (STH), Onchocerciasis (OV), and Lymphatic Filariasis (LF) in Ghana. However, elimination can be achieved only when the key players including the community members comply with the programme guidelines and requirements by participating in MDA campaigns against NTDs. The objective of the paper is to examine the factors influencing community members’ participation in MDA programs that seeks to bring the services of NTDs prevention to the doorstep of individuals. Methods: We used a population-based survey data of 1,034 people from 296 households collected in the Assin North Municipality in the Central Region of Ghana. First, chi-square test was used to test the association of socio-economic factors and participation in MDAs. Subsequently, we ran a multilevel logistic regression model to estimate the association of factors that influence non-participation in MDA by community members. Results: Nearly a quarter of respondents had once suffered from STH (22.5%) and a small fraction from bilharzia (7.4), river blindness (1.1%), and nobody suffered from LF. Although almost all respondents (97%) had ever heard of MDA campaign, 22% of respondents missed or did not participate in a MDA program. Factors that were found to correlate with non-participation in MDA programs are marital status and previously receiving tablets from a MDA campaign. Conclusion: Results showed that MDA participation by community members is relatively high and thus Ghana’s efforts at eliminating NTDs through MDA is on course. However, continues public education is required to maintain high participation and possibly improve upon it. 1The project looks at the parasitological, epidemiological as well as the socio-economic factors that influence the acceptance, effectiveness, efficiency and equity impact of scale-up from a health systems approach
ALKBH5-Mediated M6a-Demethylation Of USP1 Regulated T-Cell Acute Lymphoblastic Leukemia Cell Glucocorticoid Resistance by Stabilizing Aurora B
Authors: Gong Hongtao , Liu Liu , Cui Lina , Ma Hongyan , Shen Liyun
Published: March 2021

Recent studies have evidenced that ubiquitin-specific proteases (USPs) are associated with the occurrence and drug resistance of T-cell acute lymphoblastic leukemia (T-ALL). N6-methyladenosine (m6A) demethylase AlkB homolog 5 (ALKBH5) exerts a carcinogenic effect in human cancers and improves the mRNA stability of USPs. Whether ubiquitin specific protease 1 (USP1) controls chemoresistance in T-ALL is unknown. Our study demonstrated that USP1, Aurora kinase B (Aurora B) and ALKBH5 levels were highly expressed in glucocorticoid (GC)-resistant T-ALL patients and cells (CEM-C1). High expression of USP1 was correlated to the poor prognosis of T-ALL patients. Silencing USP1 increased CEM-C1 cell sensitivity to dexamethasone (Dex), reduced cell invasion, promoted cell apoptosis, and ameliorated glucocorticoid receptor (GR) expression. USP1 mediated T-ALL chemoresistance by interacting with Aurora B. Overexpression of USP1 reversed the promotive effects of Aurora B inhibitor on the sensitivity of CEM-C1 cells to Dex, cell apoptosis and GR level and the inhibition effect on cell invasion. Downregulation of ALKBH5 reduced the levels of USP1 and Aurora B, facilitated CEM-C1 cell sensitivity to Dex, apoptosis and GR expression, suppressed cell invasion. However, overexpression of USP1 reversed all the effects of ALKBH5 on CEM-C1 cells. In vivo results showed that tail vein injection of sh-USP1 resulted in a significant prolongation of mouse survival and maintained the normal weight of mice compared to the Dex group, reduced USP1 expression and facilitated GR expression. In conclusion, downregulation of USP1 ameliorated glucocorticoid resistance of T-cell acute lymphoblastic leukemia cells through suppressing Aurora B expression and elevating GR level.
The interplay of Malm carbonate permeability, gravity-driven groundwater flow, and paleoclimate – implications for the geothermal field and potential in the Molasse Basin (Southern Germany), a foreland-basin play
Authors: Schintgen Tom Vincent , Moeck Inga Sigrun
Published: March 2021

The Molasse Basin in Southern Germany is part of the North Alpine Foreland Basin and hosts the largest accumulation of deep geothermal production fields in Central Europe. Despite the vast development of geothermal energy utilization projects especially in the Munich metropolitan region, the evolution of and control factors on the natural geothermal field are still debated. Especially seismic and deep well data from extensive oil and gas exploration in the Molasse Basin led to conceptual hydrogeological and thermal-hydraulic models. Corrected borehole-temperature data helped to constrain subsurface temperatures by geostatistical interpolation and facilitated the set-up of 3D temperature models. However, within the geothermally used Upper Jurassic (Malm) carbonate aquifer, temperature anomalies such as the Wasserburg Trough anomaly to the east of Munich and their underlying physical processes are yet poorly understood. From other foreland basins like the Alberta Basin in Western Canada, it is known that climate during the last ice age has a considerable effect even on subsurface temperatures up to two kilometres depth. Therefore, we study the impact of paleoclimatic changes on the Molasse Basin during the last 130 ka including the Würm glaciation. We consider the hydraulic and thermal effects of periglacial conditions like permafrost formation and the impact of the numerous glacial advances onto the Molasse Basin. The major difference between the thermal-hydraulic regime in the western and eastern parts of the Southern German Molasse Basin are delineated by calculating two contrasting permeability scenarios of the heterogeneously karstified Malm carbonate aquifer. Thermal-hydraulic modelling reveals the effect of recurrent glacial periods on the geothermally drillable subsurface, which is minor compared to the effect of permeability-related, continuous gravity-driven groundwater flow as a major heat transport mechanism. Practically, the results might help to reduce the exploration risk for geothermal energy projects in the Molasse Basin. More importantly, this study serves as a reference for the comparison and understanding of the interplay of high permeability aquifers, gravity-driven groundwater flow and paleoclimate in other orogenic foreland basins worldwide.
WITHDRAWN: Zn(II) Metal-organic Framework Nanoparticles: Synthesis, Characterization and Application as Optical Biosensor for Prostate-Specific Antigen
Authors: Basaleh Amal S. , El-Sheikh S. M.
Published: March 2021

PSA, abbreviated of “Prostate-Specific Antigen” is widely used as a considered a significant cancer biomarker for diagnosing prostate cancer. Improvement of a fast, facile, and less cost with high accurate/sensitive/selective methodologies for the PSA determination is stock-still a challenge. In this work, we reported a simple biosensor based on a Zn(II) metal-organic framework nanoparticles (Zn-MOF-NPs) derived from reaction of zinc acetate with nano organic linker. The structure, morphology, and physicochemical properties of the prepared Zn(II)-MOF-NPs were definite using various spectroscopic and microanalytical tools as SEM-EDX, HR-TEM, XRD, XPS, elemental analysis, FT-IR, UV-vis spectroscopy, mass spectroscopy, thermogravimetric Analysis (DSC/TGA), and photoluminescence (PL). Obviously, the results revealed that the Zn(II)-MOF-NPs is chemical stable, highly selective and sensitive to PSA, without interferences with other common interfering analytes. The detection limit for PSA was 0.145 fg/mL, in a wide-linear range of concentrations (0.1 fg/mL-20 pg/mL), with a correlation coefficient 0.983. The Zn(II)-MOF-NPs was successfully used as an up-and-coming biosensor for PSA-monitoring and quantification in biological real samples (plasma/whole blood/serum) at clinical target concentration levels. Moreover, the present approach will help the human-beings from the hazard’s prostatic cancer through early discovery and diagnosis process via the detection of PSA at low limits of concentrations. Meantime, the interaction mechanism between the Zn(II)-MOF-NPs and PSA was well studied and investigated.
Malaria in Haiti: A Descriptive and Temporal Study from 2009 to 2018.
Authors: Jules Jean Ricardo , Alencar Jeronimo , Baptiste Ernst Jn , Suárez-Mutis Martha Cecília , Albuquerque Hermano Gomes , Rosa-Freitas Maria Goreti , Raccurt Christian , Silva-do-Nascimento Teresa Fernandes
Published: March 2021

Background

Haiti is one of the Caribbean countries where malaria still persists. Malaria occurs throughout the country at altitudes below 600 meters. More than 99% of the malaria cases are caused by Plasmodium falciparum and the main vector is Anopheles albimanus. This paper aims to describe the epidemiological profile of malaria in Haiti between 2009 and 2018.
Methods

We analyzed information on malaria cases reported by both the Health Ministry of Haiti (Ministère de la Santé Publique et de la Population-MSPP) and the World Health Organization (WHO) during the study period.
Results

Between 2009 and 2018, a total of 232,479 malaria cases were reported by the MSPP. There was an increase in the incidence of malaria in the country in 2010 followed by a decrease in 2011. Due to efforts made by Haiti over the past decade to reduce malaria by 2020, malaria incidence has declined from 60,130 cases in 2010 to 8,978 cases in 2018. We verified that the MSPP and the WHO data are conflicting in relation to the number of cases reported. However, the results from both data sets presented the same malaria trend in Haiti from 2009 to 2018. The results also show the endemicity of the disease throughout Haiti, both in rural and urban areas, especially along the coast.
Conclusion

This work emphasizes the need to promote official data collection and analyses and the application of epidemiological surveillance of malaria for a better knowledge about the real impact of malaria on the Haitian population aiming more appropriate interventions.
Luteorhabdos pelagi gen. nov., sp. nov., a novel member of the family Flavobacteriaceae, isolated from the West Pacific Ocean
Authors: Ren Wen-Ting , Meng Fan-Xu , Guo Li-Li , Sun Li , Xu Xue-Wei , Zhou Peng , Wu Yue-Hong
Published: March 2021

Gram-stain-negative, aerobic and yellow-pigmented bacterium, designated A3-108T, was isolated from seawater of the West Pacific Ocean. Cells were non-motile and rod-shaped, with carotenoid-type pigments. The strain A3-108T grew at pH 6.0-8.5 (optimum 6.5) and 15–40℃ (optimum 28℃), in the presence of 0.5–10% (w/v) NaCl (optimum 1.0%). It possessed the ability to produce H2S. Based on the 16S rRNA gene analysis, strain A3-108T exhibited highest similarity with Aureisphaera salina A6D-50T (90.6%). Phylogenetic analysis shown that strain A3-108T affiliated with the family Flavobacteriaceae and represented an independent lineage. The principal fatty acids were iso-C15:0, iso-C17:0 3-OH, iso-C15:1 G and summed feature 3 (C16:1ω7c and/or C16:1ω6c). The sole isoprenoid quinone was MK-6. The major polar lipids were phosphatidylethanolamine, one unidentified aminophospholipid, one unidentified aminolipid and one unidentified lipid. The ANIb, in silico DDH and AAI values among the genomes of strain A3-108T and the reference strains were 67.3–71.1%, 18.7–22.1% and 58.8–71.4%, respectively. The G + C content was 41.0%. Differential phylogenetic distinctiveness, chemotaxonomic differences as well as phenotypic properties revealed that strain A3-108T represented a novel genus and species of the family Flavobacteriaceae, for which the name Luteorhabdos pelagi gen. nov., sp. nov. is proposed (type strain, A3-108T = CGMCC 1.18821T = KCTC 82563T).
Mathematical study on a dynamical predator-prey model with constant prey harvesting and proportional harvesting in predator
Authors: Mortuja Md Golam , Chaube Mithilesh Kumar , Kumar Santosh
Published: March 2021

A dynamical predator-prey model with constant prey harvesting, proportional harvesting in predator has been studied. The square root func- tional response also has been incorporated in the system to describe the prey herd behaviour, assuming the average handling time is zero. The existence and the local stability of equilibria of the system have been discussed. It is examined that, two types of bifurcation occur in the system. The two types of bifurcations have been analyzed, and it has been found by analyzing the saddle-node bifurcation that, there is a maximum sustainable yield. It is ob- served that if harvesting rate is greater than the maximum sustainable yield, the prey population abolish from the system and then extinction of the preda- tor population happen. But if harvesting rate is lesser than the maximum sustainable yield, the extinction of the prey population can not be possible. By analyzing the Hopf bifurcation, it is obtained that, there exists an unstable limit cycle around the interior equilibrium point. Several numerical simulations are performed to check the results.
MONDROS MÜTAREKESİ’NİN BURSA’DA UYGULANMASI VE İŞGALİN BURSA YERELİNE SOSYOEKONOMİK ETKİLERİ
Authors: ERSEVİNÇ Mine
Published: March 2021

I. Dünya Savaşı’ndan Mondros Mütarekesi’yle çekilen Osmanlı Devleti’nin toprakları İtilaf Devletleri’nin kontrolü altına girmiş ve Anadolu’da işgaller başlamıştır. İtilaf Devletleri; Mütareke sonrası Mudanya ve Gemlik’i, 8 Temmuz’da ise Bursa merkezini işgal etmiş ve işgal 11 Eylül 1922’ye kadar devam etmiştir. Mütareke sonrası Bursa, bir yandan İtilaf Devletleri’nin desteğindeki Yunan güçleriyle bir yandan da uzun yıllar birlikte yaşadıkları Müslüman halka ihanet eden Ermeni ve Rumlarla mücadele etmek zorunda kalmıştır. Çalışmamızda amacımız; Bursa’da işgal öncesi, işgal dönemi ve işgalin sonlandırılması süreçlerinde nüfus hareketlerini, ekonomik ve kültürel değişimi incelemektir. Bursa merkez ve köylerinde yaşayan ve işgalci güçlerle hareket eden Ermeni ve Rumların Müslüman halka uyguladığı kıyımı belgelerle vererek bölgede Müslüman halk aleyhine yaşanan demografik hareketliliği açıklamak ve bu hareketliliğin Müslüman halk aleyhine dönüştürdüğü ekonomik ve kültürel değişimi de ortaya koymaktır.
Genetic Polymorphism in Peripartum Cardiomyopathy
Authors: Dewi Ivana Purnama , Nugroho Johanes
Published: March 2021

Peripartum cardiomyopathy (PPCM) is a rare type of cardiomyopathy. PPCM is a potentially life-threatening pregnancy-associated disease that typically arises in peripartum period and is marked with left ventricular (LV) dysfunction and heart failure. The cause of PPCM remain unclear, but several mechanisms have been proposed ehich indices a potentially multi-factorial etiology. Early case reports identified overlap between familial dilated cardiomyopathy (DCM) and PPCM, although the degree of overlap is largely unknown. Many evidence supporting a contribution from gene mutations in PPCM includes genome-wide association studies, familial occurrence, variable prevalence among different regions and ethnicities, and more recent investigations of panels of genes for mutations among women with PPCM. Although the true incidence of genetic cardiomyopathy is not yet known among women with PPCM, there is substantial evidence demonstrating that genetic contribution to their condition.
Primary Fallopian Tube Carcinoma: Results of a Single-Institutional Retrospective Analysis of 17 Patients with Evaluation of Staging and Prognostic Factors
Authors: Tounsi Neserine , Bouazize Hanen , Margheli Ikram , Boujelbene Nadia , Monia Hechiche , Slimane Maher , Rahel Khaled
Published: March 2021

OBJECTIVE: Primary carcinoma of the fallopian tubes is one of the less common gynecological cancers. It constitutes (0.14-0.18%) of gynecological malignancies. Our study aimed to review the managing process of primary carcinoma of the fallopian tubes in the mono-center institute and to identify prognostic factors impacting survival.
STUDY DESIGN: A retrospective cohort study regarding patients with fallopian tube carcinoma treated between July 1991 and December 2005 was identified at the Tunisian anticancer institute “Salah Azaiez”. During this period, we have identified 17 patients. Data such as age, gravidity and parity, menopausal condition, symptoms reported by the patient on presentation, adjuvant therapy, stage of illness, surgical intervention, pathological findings, tumor recurrence, and previous surgical procedures were obtained from the patients’ reports.
RESULTS: The average age at the time of diagnosis was 58 years. Fourteen of the included patients were postmenopausal. Surgery was the initial therapy for 15 patients. Optimal cytoreductive surgery was achievable in seven patients with no residual tumors. Histologic examination revealed that serous adenocarcinoma type was the predominant type. Two were in stage I and, four were in stage II; seven were in stage III and four in stage IV. The median follow-up time was 24 months. At the time of the final analysis, 11 patients died of disease. 5-year OS, DFS was 21% and 37% respectively. In our study, only the residual tumor was a significant prognostic factor predicting survival.
CONCLUSION: Complete optimal surgery with no residual tumor was the main goal of the surgeon to improved survival in primary fallopian tube carcinoma.
Hereditary symbionts and mitochondria: distribution in insect populations and quasi-linkage of genetic markers
Authors: Zakharov Ilya , Shaikevich Elena
Published: March 2021

Maternal transmission ensures the joint transmission and simultaneous presence in populations of individuals with certain variants of the bacterial symbiont and host mitochondrial DNA. Such “quasi-linkage” of cytoplasmic genomes among insects and other arthropods is widespread. The symbiont acts as a “driver” of mitochondria and the obvious biological consequence is the spread of the “linked” mitochondrial haplotype in the population, which itself does not have increased selective value to the organism. Examples of such indirect selective mitochondrial sweep in insects are discussed, as well as biological consequences of this phenomenon and mechanisms of increasing the frequency of symbiont-infected individuals in the population.
Some aspects of metal ion transport and in silico gene expression analysis of potassium/sodium ion transporters, channels and exchangers in root nodules
Authors: Trifonova Natalia , Koroleva Maria , Fedorova Elena
Published: March 2021

Rhizobia establish a symbiotic relationship with legumes, which results in the formation of root nodules, the ecological niche for intracellular rhizobia. The infected cell of a root nodule is a special integral unit of plant and nitrogen fixing rhizobia. Nodules tend to be very sensitive to ionic stresses, such as salt stress. High vulnerability toward ionic stresses might be due to defects in ion balance and transport in the infected tissue. The purpose of this minireview is to summarize the current data regarding metal ion transport in the root nodule, with particular emphasis on potassium/sodium ion transport. A bioinformatic approach and in silico gene expression analysis have been used to obtain some insight for K+/Na+ transportеr channels and exchangers in root nodule developmental zones.
Saccharomyces cerevisiae strain associated to a fish culture additive: antifungal activity and AFB1 adsorption potential
Authors: Ianiceli Juliana Alexandre , Rodrigues Aline Maria Dourado , Sousa Junior João Farias , Bacelar Rafael Gomes Abreu , Muratori Maria Christina Sanches
Published: March 2021

Saccharomyces cerevisiae is widely applied as a probiotic in aquaculture activities, due to its ability to decontaminate the mycotoxin Aflatoxin B1 (AFB1). From this point, the present study aimed to evaluate the antifungal and anti-aflatoxigenic activities of inactivated Saccharomyces cerevisiae mixed with a commercial product (CP) of animal feed to assess its influence on the Aspergillus flavus and A. parasiticus fungi growth on the AFB1 production. Besides, AFB1 adsorption potential of S. cerevisiae and the commercial product was also investigated. Different concentrations of the commercial product alone and in the presence of inactivated yeast were analyzed by Aspergillus growth inhibition test, aflatoxin production by Aspergillus species, and AFB1 adsorption capacity. AFB1 detection and quantification were carried out by High-Performance Liquid Chromatography. The inactivated yeast and commercial product combination were effective in reducing A. flavus and A. parasiticus growth. A. flavusproduced less AFB1 after the inactivated yeast treatment, whereas A. parasiticus produced significantly less AFB1under a combination of inactivated yeast and 50% CP. Regarding AFB1 adsorption, 100% CP displayed the highest adsorption capacity at 10 ng mL-1 AFB1. At 25 ng mL-1 AFB1, only the treatment comprising inactivated yeast associated with 50% CP led to AFB1 adsorption, albeit at low levels. It was concluded that the association between the commercial additive and inactivated S. cerevisiae was effective in reducing the growth of fungi and there was AFB1 adsorption activity.
Bactérias isoladas do nim Azadirachta indica (Meliaceae) sobre adultos de Spodoptera frugiperda (Lepidoptera, Noctuidae)
Authors: Irisléia Pereira Soares de Sousa  , Herika Dayane da Silva  , Adelica Aparecida Xavier  , Clarice Diniz Alvarenga Corsato  , Teresinha Augusta  Giustolin
Published: March 2021

Este trabalho teve como objetivo avaliar a patogenicidade de bactérias isoladas da planta nim, Azadirachta indica (Meliaceae), sobre os adultos de Spodopterafrugiperda (Lepidoptera, Noctuidae). Todas as suspensões bacterianas avaliadas foram calibradas para a concentração de 5,0 x 108 células/mL. Os adultos avaliados foram os sobreviventes de lagartas que ingeriram folhas de milho tratadas com as suspensões bacterianas. Com esses adultos sobreviventes se constituíram casais, que foram mantidos em gaiolas. Verificaram-se a longevidade de machos e fêmeas, o período de pré-oviposição e fértil, o número total de posturas, a fecundidade e a fertilidade das fêmeas. Do total de isolados avaliados, 64,0% deles causaram algum efeito adverso aos adultos, a ponto de afetarem uma ou mais das variáveis observadas. A ingestão das bactérias pelas lagartas reduziu a longevidade de adultos (macho e fêmea). As fêmeas tiveram redução no período fértil, no número de posturas, na fecundidade e na fertilidade. Somente o período de pré-oviposição não foi afetado. Os isolados Bacillus sp. Epi 9, Bacillus subtilis e Nim 10 são destaque, pois afetam o maior número de variáveis avaliadas. Os resultados obtidos neste trabalho são promissores e importantes, pois este é o primeiro relato de bactérias isoladas de nim com ação patogênica a S. frugiperda.
Application of ethical leadership and workers’ performance: A perspectives from public and private owned enterprises
Authors: OLANNYE Anthonia Awele
Published: March 2021

The main objective of the study was to determine the rationale of ethical leadership in public and privately-owned enterprises. It involved two public sectors and two private sector enterprises, which comprised 221 respondents from the staff and management of the enterprises as the sample size for the study. The survey research method was used in gathering information from respondents. A stratified sampling technique was adopted for the study. A validated structured questionnaire was used for data collection. The statistical techniques adopted for processing the data and testing the hypotheses for this study compared mean using independent t-test via the use of statistical package for social science (SPSS) software version 2 1. Descriptive statistics and frequency analysis were used. The mean response was tested using a t-test. The findings of the study revealed that there is no significant difference in ethical leadership between the public and private enterprises given that the variables revealed thus (Sig. = .728, P> 0.05) and  (Sig. .238, P> 0.05). The study concluded that the leadership of the public and private enterprise should have the ethical values, interpersonal qualities and capabilities to carry out the different tasks as needed by the organizations.
Preference of media politics and beginner voter trust in Surakarta
Authors: Kartinawati Erwin , Purwasito Andrik
Published: March 2021

The Indonesian Presidential Elections of 2014 and 2019 indicated the behavioral changes in mass media, especially that of private television. The involvement of media owners in the political arena can influence the content of most journalistic broadcasts. Therefore, this study aims to determine the perception of student voters in Surakarta on media houses with political preferences. This might be because the media owner is actively supporting a political party or a particular candidate. Furthermore, if the media is under the influence of politics, how can voters have trust in the information dissipated, especially during elections. The data obtained for this study was through the distribution of questionnaires to college students aged 17-25 years that are voting for the first time. Most of the respondents stated that their political choices are not necessarily influenced by the media. The belief in the media is not directly related to political preferences but depends on the content or what is conveyed to the public. However, the involvement of media owners in politics also undermines public trust in the content of the media, especially about political news.
GERİ DÖNÜŞTÜRÜLMÜŞ BETON AGREGASI KULLANILARAK ÜRETİLEN HARÇLARDA YÜKSEK SICAKLIK ETKİSİNİN ARAŞTIRILMASI
Authors: ÇINAR Emriye , DÜNDAR Behcet , UYGUNOĞLU Tayfun
Published: March 2021

Bu çalışmada, Geri Dönüştürülmüş Beton Agregasının (GDA) harç numunelerinde kullanımı ve yüksek sıcaklık altında harçlara etkisi araştırılmıştır. Harç numuneleri 40x40x160 mm boyutlarında üretilmiştir. İnce agrega haline getirilen GDA, harç üretiminde kullanılan kırma kum ile %25, %50 %75 ve %100 oranlarında yer değiştirme yapılmıştır. Harç numuneler 28 gün standart kür sonunda 200, 400, 600 ve 800 ⁰C sıcaklıklara maruz bırakılmıştır. Uygulanan sıcaklık sonrası ultrases geçiş hızı, ağırlık kayıpları, eğilme ve basınç dayanımları belirlenmiştir. GDA’nın artmasıyla birlikte harçların fiziksel ve mekanik özeliklerinde azalmalar meydana gelmiştir. Sıcaklığın artmasıyla birlikte de ultrases geçiş hızı, basınç ve eğilme dayanımlarında azalma görülmüştür.
ŞEFAATLİ (YOZGAT) DOĞUSU SU KAYNAKLARININ HİDROJEOLOJİK VE HİDROJEOKİMYASAL İNCELEMESİ
Authors: ŞENER Şehnaz , ŞENER Erhan
Published: March 2021

Bu çalışmada, Yozgat ili, Şefaatli ilçesi doğusu yüzey ve yeraltısularının hidrojeolojik ve hidrojeokimyasal özellikleri incelenmiştir. Bölgede yüzeyleyen jeolojik birimler hidrojeolojik özelliklerine göre Akifer-1, Akifer-2, Akitard ve Aküfüj olmak üzere dört ayrı grupta incelenmiştir. Mayıs (2019) döneminde yapılan yeraltısuyu seviye ölçüm sonuçlarına göre bölgede yeraltısuyu derinlikleri 3,22 m ile 20 m arasında, yeraltısuyu seviye değerleri ise 945,25 m ile 1045,05 m arasındadır. Bölgede, yeraltısuyu akımının, güneydoğudan kuzeybatıya doğru olduğu belirlenmiştir. Aynı dönemde yeraltısuyu ve yüzeysularından alınan su örneklerinin hidrojeokimyasal özellikleri, su kalitesi ve kullanım özellikleri belirlenmiştir. Buna göre su örnekleri Na-Ca-HCO3, Ca-Mg-HCO3 ve Ca-Mg-HCO3-SO4’lı sular fasiyesinde yer almaktadır.

Su örneklerin kimyasal analiz sonuçlarına göre yeraltısularının Al ve As parametreleri bakımından, yüzey sularının ise Al, As, Mn ve Fe parametreleri bakımından içme suyu olarak kullanıma uygun olmadığı belirlenmiştir. Su kaynaklarında söz konusu parametrelerin artışı kaya-su etkileşimi ile gelişmektedir. Ayrıca, bölgedeki tarımsal faaliyetler ile ilişkili olarak yeraltısuyu örneklerinin NO3 değerlerinin içme suyu limit değerlerin üzerinde olduğu belirlenmiştir.
ANKARA - İZMİR YÜKSEK HIZLI TREN PROJESİNİN AFYON - UŞAK (EŞME) KESİMİNDEKİ KAYA BİRİMLERİNİN JEOTEKNİK DEĞERLENDİRMESİ
Authors: ÖZÇELİK Mehmet
Published: March 2021

Bu çalışmada, Ankara - İzmir Yüksek Hızlı Tren (YHT) projesinin Afyon - Uşak (Eşme) (Km 364+600 - 409+500) (52 menfez, 10 üst geçit, 4 alt geçit, toplam 1878.59 m uzunluğunda aç kapa tünel, toplam 22331.35 m uzunluğunda 24 tünel için) kesimindeki kaya birimlerinin jeoteknik özelliklerinin araştırılması amaçlanmıştır. Yapılmakta olan YHT için proje güzergahındaki kaya birimlerinin kütle özelliklerinin araştırılması ve mühendislik uygulamaları açısından bir görüş oluşturulması hedeflenmiştir. YHT güzergahı ve yakın civarında yüzeyleyen mevcut kaya birimleri olarak Menderes Metamorfitleri ve kısa bir mesafede ise graben dolgusu olarak tanımlanabilecek tortul örtü üzerinde ilerleyecektir. Kaya birimlerin destekleme ve tasarımı için kullanılan Kaya Kütlesi Puanlama Sistemi (RMR) ve Kaya Kütlelerinin Mühendislik Sınıflaması (Q) dır. YHT güzergahındaki kayaların jeoteknik özellikleri ve kaya süreksizliklerinin değerlendirilmesi yapılmıştır. RMR değerine göre Kaya Kütlesi Sınıfı; ortognays için “orta kaliteli kaya”, Neojen tortullar “iyi kaya”, şist “çok kötü kaya”, granit ise “çok iyi kaya” belirlenmiştir. Q sınıflama sistemine göre güzergahtaki kaya birimlerinin Kaya Destek Sınıfı; ortognays “zayıf kaya” , Neojen birimler “iyi kaya”, şist “çok fazla zayıf kaya” ve granit birimi ise “pek çok iyi kaya” olarak tanımlanmışlardır.
KALÇA PROTEZİ TASARIMININ SONLU ELEMANLAR YÖNTEMİ İLE STATİK ANALİZİ
Authors: KAYA Fatih , İNCE Gülhan , AVCAR Mehmet , YÜNLÜ Lokman
Published: March 2021

Total kalça protezi tasarımında protez performansı ve kullanım ömrünün artırılmasına yönelik çalışmalar gelişen cerrahi yöntemlerin yanı sıra malzeme ve üretim teknolojileriyle beraber son yıllarda oldukça hız kazanmıştır. Değişen ve gelişen biyomedikal teknolojisine her geçen gün ayak uydurabilen pratik yapısal ve mekanik çözümler günümüz mühendislik biliminin temel sorunlarından biri haline gelmiştir. Bu nedenle bilim insanlarının ilgi odağı, farklı malzemelerden yapılmış yapısal ve mekanik bileşenlerin farklı davranışlarına ilişkin analitik, sayısal ve deneysel çalışmalar olmuştur. Sonlu elemanlar yöntemi yeni protez tasarımlarının dayanım performansları hakkında prototip üretimi ve fiziksel testler yapılmaksızın gerçeğe oldukça yakın önemli bilgiler sağlamaktadır. Sunulan çalışmada kalça protezlerinde yaygın olarak kullanılan Ti-6Al-4V malzemesi kullanılarak ASTM F2996-20 kalça protezi sapı modeli üzerinde sonlu elemanlar yöntemi ile statik analiz yapılarak protezin performansı incelenmiştir. Ayrıca mesh tipi ve eleman boyutunun gerilme ve birim şekil değiştirmeler üzerindeki etkileri nümerik olarak ANSYS 19 paket programı kullanılarak ele alınmıştır. Elde edilen sonuçlardan, eleman boyutunun 1mm’den küçük olması durumunda, gerilme ve birim şekil değiştirmeler üzerinde etkisi olmadığını fakat işlem süresini oldukça arttırarak çözümü ekonomiklikten uzaklaştırdığı görülmüştür.
The relationship between selfie addiction, nomophobia and locus of control: a cross-sectional, web-based survey (Preprint)
Authors: Chen Wen , Boggero Andrea , del Puente Giovanni , Jahrami Haitham , Chalghaf Nasr , Guelmami Noomen , Azaiez Fairouz , Bragazzi Nicola Luigi
Published: March 2021

BACKGROUND

Selfie addiction is one of the behavioral addictions or addictive behaviors that have recently emerged, together with the internet addiction, the smartphone addiction.

OBJECTIVE

The aim of the investigation was to explore the relationships between selfie addiction, nomophobia and locus of control.

METHODS

242 subjects (median age 26 years, n=182, 75.2%, females and n=60, 24.8%, males) were recruited. The primary objective of the study was to validate the Italian translation of the Selfie-liking Scale conceived by Charoensukmongkol, a short scale used to measure the attitude towards the use of the selfie. The second part of the research links this test with the Nomophobia Questionnaire (NMP-Q), used to measure the level of nomophobia in the participants and, finally, we have related the Selfie-liking Scale with the Internal-External (I-E) Rotter Scale, used to measure the orientation of the Locus of Control, with particular attention to the external orientation of this psychological construct.

RESULTS

Cronbach’s alpha in Selfie-liking Scale was good (0.88). A significant correlation was found between the total score of the selfie scale and nomophobia and correlation between external locus of control and selfie resulted statistically borderline.

CONCLUSIONS

The selfie-liking scale is a reliable instrument and can be utilized in future studies to explore further psuychological determinants of such a behavior.
Googling for Suicide–Content and Quality Analysis of Suicide-Related Websites: Thematic Analysis (Preprint)
Authors: Chen Wen , Boggero Andrea , Del Puente Giovanni , Olcese Martina , Prestia Davide , Jahrami Haitham , Chalghaf Nasr , Guelmami Noomen , Azaiez Fairouz , Bragazzi Nicola Luigi
Published: March 2021

BACKGROUND

Suicide represents a public health concern, imposing a dramatic burden. Prosuicide websites are “virtual pathways” facilitating a rise in suicidal behaviors, especially among socially isolated, susceptible individuals.

OBJECTIVE

The aim of this study is to characterize suicide-related webpages in the Italian language.

METHODS

The first 5 most commonly used search engines in Italy (ie, Bing, Virgilio, Yahoo, Google, and Libero) were mined using the term “suicidio” (Italian for suicide). For each search, the first 100 webpages were considered. Websites resulting from each search were collected and duplicates deleted so that unique webpages could be analyzed and rated with the HONcode instrument

RESULTS

A total of 65 webpages were included: 12.5% (8/64) were antisuicide and 6.3% (4/64) explicitly prosuicide. The majority of the included websites had a mixed or neutral attitude toward suicide (52/64, 81.2%) and had informative content and purpose (39/64, 60.9%). Most webpages targeted adolescents as an age group (38/64, 59.4%), contained a reference to other psychiatric disorders or comorbidities (42/64, 65.6%), included medical/professional supervision or guidance (45/64, 70.3%), lacked figures or pictures related to suicide (41/64, 64.1%), and did not contain any access restraint (62/64, 96.9%). The major shortcoming to this study is the small sample size of webpages analyzed and the search limited to the keyword “suicide.”

CONCLUSIONS

Specialized mental health professionals should try to improve their presence online by providing high-quality material.
Creation of a Student-Run Medical Education Podcast: Tutorial (Preprint)
Authors: Milligan Kevin John , Daulton Robert Scott , St Clair Zachary Taylor , Epperson Madison Veronica , Holloway Rachel Mackenzie , Schlaudecker Jeffrey David
Published: March 2021

BACKGROUND

Podcasting has become a popular medium for medical education content. Educators and trainees of all levels are turning to podcasts for high-quality, asynchronous content. Although numerous medical education podcasts have emerged in recent years, few student-run podcasts exist. Student-run podcasts are a novel approach to supporting medical students. Near-peer mentoring has been shown to promote medical students’ personal and professional identity formation. Student-run podcasts offer a new medium for delivering near-peer advice to medical students in an enduring and accessible manner.

OBJECTIVE

This paper describes the creation of the UnsCripted Medicine Podcast—a student-run medical education podcast produced at the University of Cincinnati College of Medicine.

METHODS

The planning and preparatory phases spanned 6 months. Defining a target audience and establishing a podcast mission were key first steps. Efforts were directed toward securing funding; obtaining necessary equipment; and navigating the technical considerations of recording, editing, and publishing a podcast. In order to ensure that high professionalism standards were met, key partnerships were created with faculty from the College of Medicine.

RESULTS

The UnsCripted Medicine Podcast published 53 episodes in its first 2 years. The number of episodes released per month ranges from 0 to 5, with a mean of 2.0 episodes. The podcast has a Twitter account with 217 followers. The number of listeners who subscribed to the podcast via Apple Podcasts grew to 86 in the first year and then to 218 in the second year. The show has an average rating of 4.8 (out of 5) on Apple Podcasts, which is based on 24 ratings. The podcast has hosted 70 unique guests, including medical students, resident physicians, attending physicians, nurses, physicians’ family members, graduate medical education leadership, and educators.

CONCLUSIONS

Medical student–run podcasts are a novel approach to supporting medical students and fostering professional identity formation. Podcasts are widely available and convenient for listeners. Additionally, podcast creators can publish content with lower barriers of entry compared to those of other forms of published content. Medical schools should consider supporting student podcast initiatives to allow for near-peer mentoring, augment the community, facilitate professional identity formation, and prepare the rising physician workforce for the technological frontier of medical education and practice.
Consultation Pricing of the Online Health Care Service in China: Hierarchical Linear Regression Approach (Preprint)
Authors: Chiu Ya-Ling , Wang Jying-Nan , Yu Haiyan , Hsu Yuan-Teng
Published: March 2021

BACKGROUND

Online health care services are a possible solution to alleviate the lack of medical resources in rural areas, and further understanding of the related medical service pricing system would contribute to improvement of the online health care community (OHC). Although many studies have investigated the OHC, the impact of physicians’ reputations and wage levels on consulting prices in the OHC has rarely been discussed in the literature.

OBJECTIVE

This study was designed to explore the determinants of consulting prices in the OHC. We addressed the following questions: (1) Are the prices of online health consultation services affected by wage levels at the doctor’s location? (2) How does a physician’s online and offline reputation affect their consulting prices?

METHODS

Employing a large-scale sample of 16,008 doctors in China, we first used descriptive statistics to investigate the determinants of consulting prices in their entirety. Hierarchical linear modeling was then used to investigate the determinants of consulting prices in the OHC.

RESULTS

The empirical results led to the conclusion that if doctors have more elevated clinic titles, work in higher-level hospitals, have better online reputations, and/or have made more past sales, their consulting prices will be higher. Additionally, the wage level in the city in which the doctor is working determines their opportunity cost and therefore also affects consulting prices.

CONCLUSIONS

The findings indicate that the characteristics of the doctor, the doctor’s online reputation, and past sales affect the consulting price. In particular, the wage level in the city affects the price of the consultation. These findings highlight that the OHC is important because it can indeed break through geographical restrictions and give rural residents the opportunity to obtain medical service from doctors in big cities. However, doctors from cities often charge higher fees because of their higher opportunity cost. The results reveal that one of the most important functions of the OHC is to reduce the medical disparity between urban and rural areas; however, planners appear to ignore the possibility that rural residents with lower incomes may not be able to afford such high medical consultation costs. Therefore, the government should consider providing incentives to encourage urban doctors to provide discounts to rural residents or directly offer appropriate subsidies.
The Psychosocial Impacts of COVID-19 on a Sample of Australian Adults: Cross-sectional Survey and Sentiment Analysis (Preprint)
Authors: Ryan Jillian , Sellak Hamza , Brindal Emily
Published: March 2021

BACKGROUND

The COVID-19 pandemic has had enormous impacts on people’s lives, including disruptions to their normal ways of behaving, working, and interacting with others. Understanding and documenting these experiences is important to inform the ongoing response to COVID-19 and disaster preparedness efforts.

OBJECTIVE

The aim of this study was to examine the psychosocial impacts of COVID-19 on a sample of Australian adults.

METHODS

The data analyzed were derived from a larger cross-sectional survey of Australian adults that was administered during the month of May 2020. Participants (N=3483) were asked in which ways COVID-19 had most greatly impacted them; the responses produced a text data set containing 1 COVID-19 impact story for each participant, totaling 86,642 words. Participants also completed assessments of their sociodemographic characteristics (sex, age, financial stress), level of concern related to COVID-19, personality trait profile, and satisfaction with life. Impact stories were analyzed using sentiment analysis and compared against the Theoretical Domains Framework to determine the most frequently impacted life domains. Finally, a multinomial regression analysis, stratified by participant sex, was conducted to identify the associations of psychological and demographic socializations with sentiment toward COVID-19.

RESULTS

In total, 3483 participants completed the survey, the majority of whom were female (n=2793, 80.2%). Participants’ impact stories were most commonly categorized as neutral (1544/3483, 44.3%), followed by negative (1136/3483, 32.6%) and positive (802/3483, 23.1%). The most frequently impacted life domains included behavioral regulation, environmental context and resources, social influences, and emotions, suggesting that the COVID-19 pandemic was impacting these areas of participants’ lives the most. Finally, the regression results suggested that for women, lower satisfaction with life and higher financial stress were associated with increased likelihood of negative, rather than positive, sentiment (P<.001); however, the proportion of variance in the sentiment that was explained was very small (<5%).

CONCLUSIONS

Participant sentiment toward COVID-19 varied. High rates of neutral and negative sentiment were identified. Positive sentiment was identified but was not as common. Impacts to different areas of people’s lives were identified, with a major emphasis on behavioral regulation and related domains such as social influences, environmental context and resources, and emotions. Findings may inform the development of mental health and social support resources and interventions to help alleviate the psychosocial consequences of disaster response measures.