bluuebunny/crossref_metadata_2025 huggingface dataset:
Xanthine oxidase inhibitory activity of Arcangelisia flava
Authors: Fatmawati  , Subandrate  , Safyudin  , Medina Athiah  , M Fitra Romadhon  , Aulia Firdha Tariza
Published: February 2023

Background: Hyperuricemia is characterized by elevated levels of uric acid in the blood, produced from its precursor's xanthine and hypoxanthine via xanthine oxidase. Arcangelisia flava, an herbal medicine containing flavonoids, may decrease uric acid levels by inhibiting the xanthine oxidase.

Objective: This study was to determine the effectiveness of ethanol extracts of A. flava leaves and stems in inhibiting xanthine oxidase. 

Methods:  The leaves and stems of A. flava were extracted using ethanol 96%. Xanthine oxidase activity was measured using UV Vis spectrophotometry and represented as IC50 value. Allopurinol was used as a positive control.   

Results: The IC50 value of xanthine oxidase inhibitory of ethanol extract of A. flava leaves and stems as well as allopurinol was 174.62, 30.44, 24.03 ppm.

Conclusion: The stems of A. flava have the activity of lowering uric acid levels better than the leaves.
The Implementation of Literature Circles Strategy for Vocabulary Learning: A Case Study of SMP Negeri 1 Imogiri, Indonesia
Authors: Nurmayanti Elly , Syamsi Kastam
Published: February 2023

This research aims to describe the implementation of the Literature Circles strategy to the material of observation report text at Grade VIII SMP of Negeri 1 Imogiri. This study is qualitative research. This research describes several things related to the implementation of the literature circle strategy in the material of the observation report at grade VII SMP of Negeri 1 Imogiri. Data collection was done through interviews, observation, and documentation. The research subjects were teachers, researchers themselves, and students. The data analysis technique used is an interactive analysis technique that consists of 4 steps: data collection, data reduction, data presentation, and data conclusion. The data validation used is triangulation in the form of methods and contents. The results of the research show that the implementation of the Literature Circles strategy to vocabulary learning in the observation report text is well applied. In addition, the implementation or application of this strategy is also suitable for the material observation report text, which analyzes vocabulary, especially foreign terms.
Unravelling Images of Women in the Wedding Agreement Film: A Feminist Study
Authors: Wulandari Putri Ayu , Syamsi Kastam
Published: February 2023

This study aims to determine the image of women in the wedding agreement film that aired on the Indonesian big screen on August 8, 2019. The wattpad script was written by the pen name Mia Chuz whose real name is Eria Chuzaimiah. There are three images of women raised in this study: 1) the image of women in the psychological aspect, 2) the image of women in the physical aspect, and 3) the image of women in the social aspect of society. This study uses a descriptive qualitative method by collecting data through films that the researchers watched carefully; the theory used in this study is the feminism theory; the results of this study are that there are 10 images of women in psychological aspects, 3 images of women in physical aspects, and 5 images of women in physical aspects. The Image of Women in the Social Aspects of Society.
Reality of the Real Lecturer, Tutor and Teacher: A Discussion Paper
Authors: Obeid Salah , Balol Nawal Salih Ahmed , Hamza Sabah  Mohamed Abass
Published: February 2023

The aim of this academic paper is to discuss and illustrate the significant role and duties of a lecturer, a tutor and a  teacher in the process of learning and explain their utmost contribution to the promotion of the students educationally, emotionally and ethically. At the beginning of the academic paper, a brief description has been explained to distinguish between the teacher and the lecturer and between the tutor and the instructor. Then, the duties and responsibilities of a lecturer, a tutor and a  teacher have been clarified. It is recommended that teachers and lecturers should be real leaders to their students and encourage them to improve their standard of education and promote their personalities by adopting better qualities and ethics in their life. Educational centers are expected to give more emphasis on the importance of training teachers, lecturers and tutors in order to help them teach and react to students positively and efficiently.
PHYTOCHEMICAL CONSTITUENTS AND PROXIMATE COMPOSITION OF BAMBARA GROUNDNUT (Vigna Subterranean) AND PIGEON PEA (Cajanus cajan) UNDERUTILIZED IN CALABAR, CROSS RIVER STATE
Authors: Ekpo Grace Ime , Eteng Ofem Effiom , Bassey Stella Oyom , Peculiar Wlkinson , Eteng Mbeh
Published: February 2023

The proximate constituents and phytochemical compositions of Bambara groundnut (Vigna subterranean) and Pigeon pea (Cajanus cajan) underutilized in Calabar, Cross River States was investigated. The research will provide solutions to food availability and affordability to interlock their abundance in complex carbohydrates, plant-based proteins, unsaturated fatty acids and essential minerals. Bambara groundnut (Vigna subterranean) and pigeon pea (Cajanus cajan) obtained from markets in Anambra State and Ugep, Cross River State. The plant extracts were assessed for the existence of phytochemicals by using standard procedures. Phytochemical screening revealed that the plant species used in this research contained alkaloids, flavonoids, and polyphenols. Proximate analysis of the seeds revealed the moisture content of 9.70% for Bambara groundnut and 10.01% for Cajanus, crude fat of 7.50% for Bambara groundnut and 4.50% for Cajanus cajan, ash content of 3.21% for Bambara groundnut and 3.31% for Cajanus cajan, crude protein of 25.01% for Bambara groundnut and 23.06% for Cajanus cajan, and carbohydrates composition of 70.41% for Bambara groundnut and 71.04% for Cajanus cajan. The presence of phytochemicals such as flavonoids, alkaloids, and polyphenols explained the medicinal action of the plants encountered in their therapeutic usage to meet both domestic and commercial needs.
Patch Testing of Thai Children with Eczema
Authors: Puangpet Pailin , Boonpuen Niorn , Saipornchai Kasira , Suchaoin Rungrat , Poompakdeepan Pattarida , McFadden John
Published: February 2023

Objective: To detect contact allergy rate and common allergens in Thai children presented with eczema.
Materials and Methods: A total of 124 children, aged 1-15 years, were patch tested using a pediatric screening series of 16 allergens and relevant additional allergens. Data on clinical presentation, atopic history and test results were collected.
Results: Contact allergy was found in 51 of 124 children (41.1%) presented with all forms of eczema. The common allergens were lanolin alcohol (8.9%), cocamidopropyl betaine (8.1%), nickel sulfate (7.3%), fragrance mix I (5.6%), formaldehyde (5.6%), thimerosal (5.6%), fragrance mix II (4.8%), cobalt chloride (4.0%), methylchloroisothiazolinone/methylisothiazolinone (2.4%), methylisothiazolinone (2.4%) and thiuram mix (2.4%). Nineteen of 50 atopic dermatitis patients (38%) showed positive patch test reactions.
Conclusion: Allergic contact dermatitis is common in children. Both atopic and non-atopic patients can develop contact dermatitis. Patch testing should be performed in children presented with eczema regardless of contact dermatitis history.
Perceptions and Management Practices of Onychomycosis Among Thai Physicians
Authors: Limphoka Pichaya , Leeyaphan Charussri , Sereeaphinan Chudapa , Chanyachailert Pattriya , Bunyaratavej Sumanas , Hau Carren
Published: February 2023

Objective: To examine the proportion of physicians who conducted mycological laboratory procedures to confirm a diagnosis of onychomycosis. The secondary purpose was to evaluate the practical management of physicians, comparing general practitioners and dermatology-related physicians.
Materials and Methods: This cross-sectional study and questionnaire-based research was conducted during 2021-2022. The questionnaire was composed of questions related to the practical management of onychomycosis, including diagnosis and treatment.
Results: Overall, 143 physicians were recruited to take part in this study. The number of physicians who conducted direct examination with potassium hydroxide was 99 (69.2%). The number of dermatology-related physicians who conducted mycological laboratory examinations to confirm the diagnosis was significantly higher than among general physicians (95.8% vs. 52.2%; p<0.001). Feet examination and determination of poor prognostic factors, such as elderly age, nail thickness, presence of dermatophytoma and nondermatophytes infection, were done by the dermatology-related physicians in significantly higher numbers. Blood testing before starting treatment for onychomycosis with oral antifungal medications seemed to be higher (87.5%) in the dermatology-related group. Moreover, mycological re-evaluation after treatment cessation was more significantly requested by the dermatologyrelated participants (75% vs. 15.8%, p<0.001).
Conclusion: Laboratory confirmation, feet examination, and the recognition of poor prognostic factors were significantly lower in the general practitioner group. These findings should raise awareness for improving further education about onychomycosis management in medical students, since mycological laboratory examination is crucial for diagnosis and it is helpful in guiding the proper disease management for complete disease remission.
Clinical Features of Adult Male Acne in a Tropical Country: A Prospective Cross-sectional Study
Authors: Likitwattananurak Chayanee , Chularojanamontri Leena , Tuchinda Papapit , Kulthanan Kanokvalai
Published: February 2023

Objective: To evaluate the characteristics of post-adolescent male patients with acne in terms of the onset of the condition, its clinical course and severity, and the behaviors associated with its severity.

Materials and Methods: A prospective, cross-sectional study was conducted on adult males with acne who visited Siriraj Hospital, Thailand. All male acne patients aged 21 years and older were enrolled. Diagnoses and physical examinations were performed by dermatologists.

Results: Seventy-two patients (mean age, 26.9 [± 4.3] years) were included. Persistent acne, relapse acne, and late-onset acne (onset at age ≥ 21 years) were reported in 62.5%, 33.3%, and 4.2% cases, respectively. Persistent acne tended to subside at 26 years of age, whereas late-onset acne tended to start at 28 years of age. The acne severity was mild in most cases. Pimple-picking, followed by frequent face washing, were common habits among male acne patients. Shaving influenced the severity in some adult male with acne.

Conclusion: Adult male acne commonly presented as inflammatory lesions and comedones on the cheeks. They commonly had an onset earlier than 21 years old and continued into adulthood, but the post-adolescent severity tended to be mild. While several factors have been reported elsewhere to be involved in the severity of acne, this study found that only shaving influenced severity.
Human-pet Relationship, Pet Abandonment, and Clinical Correlation for Patients Infected with Dermatophytosis of the Glabrous Skin
Authors: Sombatmaithai Sanchai , Bunyaratavej Sumanas , Chanyachailert Pattriya , Limphoka Pichaya , Rujitharanawong Chuda , Prasertsook Suthasanee , Leeyaphan Charussri , Hau Carren
Published: February 2023

Objective: The study on human-pet relationship and pet abandonment among dermatophytosis patients is limited. This study aims to review these correlations.
Materials & Methods: A two-year retrospective cross-sectional study was conducted. Case record forms were reviewed for clinical manifestations, fungal identification, human-pet relationships, and changes in the relationships after dermatophytosis diagnosis.
Results: A total of 230 dermatophytosis patients from the Dermatology outpatient clinic, Siriraj Hospital, were included. The mean age was 41.9 ± 19.1 years and 51.3% were female. Among 170 cases with positive fungal culture, zoophilic dermatophytosis from M. canis infection was identified in 15.9% which was predominately found in females and manifested as shorter duration of onset, and higher involvement on exposed areas when compared to anthropophilic dermatophytosis. Most (71%%) of patients with M. canis infection classified themselves as pet-lovers. The relationship with pets had changed after the dermatophytosis diagnosis in 41% of them which was statistically different from 8.8% in non-pet lovers (P = 0.001). The overall pet abandonment rate was 26.6%. The abandonment rate was 40.9% among non-pet lovers, while 30.6% was reported among pet lovers.
Conclusion: Zoophilic M. canis infection was associated with rapid onset and on predominant-exposed areas. Some pets could be asymptomatic, so identification of the reservoirs of dermatophytosis is important in the treatment process and helps prevent future recurrence. Paying attention to human-pet relationships and pet abandonment is critical. Knowledge about dermatophytosis transmission, and appropriate pet management should be advised to decrease abandonment.
Association Between the Level of Inflammation at Each Anatomical Sexual Activity from Gram Staining and Neisseria gonorrhoeae and Chlamydia trachomatis Infections
Authors: Chinhiran Kittipoom , Kittiyaowamarn Rossaphorn , Bamrungsak Busara , Yuchui Narissara , Boonprathueng Kornsiri , Girdthep Natnaree , Karnpanich Thanyaporn , Phinyo Phichayut , Wongyikul Pakpoom , Wi Teodora Elvira
Published: February 2023

Objective: This study aimed to determine the association between the severity of inflammation at each anatomical sexual activity from gram staining with Neisseria gonorrhoeae (NG) and Chlamydia trachomatis (CT) infections.
Materials & Methods: This study was conducted using laboratory test data from patients at the Bangrak Sexually Transmitted Infections Center. The data obtained consisted of gram staining, which was divided by the number of polymorphonuclear leukocytes (PMNL), NG culture, and Nucleic Acid Amplification Test (NAAT) for NG and CT results.
Results: For the diagnostic association between PMNL and NG infection, the results revealed that samples with urethral PMNL 3+ or 4+ carried a significant likelihood ratio (LR) for positive infection, LR 5.61 (P<0.001) and LR 59.66 (P<0.001), respectively. Cervical, rectal, and pharyngeal PMNL was not related to infection. For CT infection, urethral gram stains with PMNL levels were greater than or equal to 2+ and cervical specimens with PMNL 4+ were associated with CT infection. Rectal and pharyngeal PMNL showed no significant association with CT infection.
Conclusion: Determination of PMNL levels from gram staining contributes to the diagnosis of patients with NG and CT in the urethra, particularly for patients with a high degree of inflammation.
Prevalence and Trend of Photodermatoses in Thailand: A 16-year Retrospective Study at Siriraj Hospital
Authors: Likittanasombat Surachanee , Silpa-archa Narumol , Chaiyabutr Chayada , Nitiyarom Rattanavalai , Wisuthsarewong Wanee , Wongpraparut Chanisada
Published: February 2023

Objective: Photodermatoses are a group of cutaneous disorders with abnormal reactions triggered by exposure to sunlight. Previous studies reported varying photodermatoses prevalence in Caucasians and African-Americans; however, it was seldom reported in the Asian population. The aim of our study was to determine the prevalence, clinical characteristics and trend of photodermatoses in Thailand.
Materials & Methods: A retrospective chart review was performed at the Faculty of Medicine Siriraj Hospital, Mahidol University using diagnoses from the International Classification of Disease (ICD), Tenth Revisions codes, between January 2005 and September 2021.
Results: A total of 561 patients with definite diagnosis of photodermatoses were identified. The prevalence of photodermatoses in the outpatient dermatology clinic was 3 cases per 1,000. The most common photodermatoses was chemical and drug-induced photosensitivity (39.4%), followed by immunologically-mediated photodermatoses (30.1%), photo-aggravated dermatoses (29.4%) and genophotodermatoses (1.1%). Overall phototesting was performed in 276 cases (49.2%). In our study, some photodermatoses had unique clinical characteristics including pinpoint popular variant of polymorphous like eruption and adult-onset actinic prurigo. Over 16 years, the trend of patients being diagnosed with photodermatoses has continued to rise gradually with an increment of 1.67 times.
Conclusion: Photodermatoses are uncommon in Thailand. Some photodermatoses have distinctive clinical features in Asian populations. The trend of photodermatoses in Thailand is continually rising, reflecting an increase in physicians’ awareness and knowledge of these cutaneous conditions.
Diphenylcyclopropenone Treatment Outcomes for Alopecia Areata
Authors: Varothai Supenya , Thuangtong Rattapon , Sonmek Daranee , Iamphonrat Thanawan
Published: February 2023

Objective: To ascertain (1) Diphenylcyclopropenone (DCP)’s efficacy in treating alopecia areata (AA), alopecia totalis (AT), and alopecia universalis (AU) in Thai patients; and (2) prognostic factors.
Materials & Methods: We retrospectively reviewed the medical records of patients with AA, AT, and AU who were administered DCP at Siriraj Hospital, Bangkok, Thailand. The median response and relapse times of the 3 groups were evaluated. Factors affecting outcomes were investigated.
Results: Fifty-nine cases were enrolled (AA, 22; AT, 9; AU, 28), with women predominating in each group. The overall response was 61% (AA, 78.6%; AT, 66.7%; AU, 50%). The median response time was 58 weeks, with a significantly longer time for AU than AA (P = 0.006). Factors significantly influencing response to DCP, evaluated by multivariate analysis, were older age at onset (P = 0.02), disease duration before DCP initiation (P = 0.003), and treatment duration to initial hair regrowth (P = 0.001). The overall relapse rate was 63.9%, with a median of 39 weeks between response and relapse. The most common side effect was blistering (73.7%).
Conclusion: DCP is effective and safe for treating extensive AA. Favorable prognostic factors are low disease severity, late disease onset, short duration before DCP treatment, and short duration to initial response. As the relapse rate is high, maintenance therapy should be considered.
Histopathological Diagnosis of Alopecia Clinically Relevant to Alopecia Areata
Authors: Lekhavat Chinmanat , Rattanaumpawan Pinyo , Tosti Antonella , Korviriyakamol Tarinee , Jerasutat Suthep , Sudtikoonaseth Poonnawis , Pattanaprichakul Penvadee
Published: February 2023

Objective: To study the histopathological diagnosis of alopecia clinically relevant to AA and to compare the histopathology between acute and chronic AA divided by time to onset at three and six months.
Materials & Methods: We conducted a cross-sectional study of 113 patients with typical manifestation of AA. Two scalp biopsies were done horizontally and vertically to confirm diagnosis. Histological findings of AA in the acute group were subsequently compared with the chronic group. 
Results: Of the 113 eligible patients, 109 (96.5%) were pathologically diagnosed with AA. Other diagnoses included lichen planopilaris, lupus panniculitis, and unspecified scarring alopecia. The percentage of terminal telogen hairs in the acute group was significantly higher than the chronic group (mean % anagen: % telogen ratio = 21.2%:78.8% vs. 36.0%:64.0%; p = 0.016), while the chronic group had a significantly higher number of follicular streamers (mean ± SD; 2.5 ± 2.2 vs. 3.7 ± 2.6; p = 0.023). The number of vellus hairs significantly increased in the acute group at the six-month onset (p = 0.006). The number of nanogen hairs also increased significantly in the chronic group at both the three- and six-month onset (p = 0.020 and p = 0.007).
Conclusion: Typical manifestations of AA are not always diagnosed as AA. Acute AA has more terminal telogens and vellus hairs, while chronic AA has more follicular streamers and nanogen hairs.
Direct Immunofluorescence in Cutaneous and Systemic Lupus Erythematosus: A Literature Review
Authors: Rujitharanawong Chuda , Kulthanan Kanokvalai , Tuchinda Papapit , Pinkaew Samruay , Chanchaemsri Nattacha , Nuttawong Sasipha , Chularojanamontri Leena
Published: February 2023

Cutaneous manifestations of lupus erythematosus (LE) have a variety of clinical phenotypes and require proper investigation for diagnosis. Knowledge of the direct immunofluorescence (DIF) technique has improved and played an important role in the diagnosis of cutaneous LE. This review explores and summarizes reported DIF findings of each cutaneous LE variant.  Historically, DIF findings of cutaneous LE have revealed deposits of multiple immunoreactants at the dermo-epidermal junction with either linear or granular patterns. Immunoglobulin M is the most common immunoreactant and DIF findings of cutaneous LE variants overlap. Therefore, diagnosis of cutaneous LE requires a combination of monitoring patient history, physical examinations and laboratory studies. This review helps interpret and better understand the application of DIF studies in cutaneous LE.
A 30-year Patch Testing Experience at Siriraj Dermatology
Authors: Kanokrungsee Silada , Chaweekulrat Pichanee , Chaiyabutr Chayada , Prasertsook Suthasanee , Sereeaphinan Chudapa , Bunyavaree Monthathip , Kumpangsin Titinun , Thumrongtharadol Janista , Boonchai Waranya
Published: February 2023

Objective:  To identify trends of contact allergy and patch testing amendments at the Contact Dermatitis Clinic, Department of Dermatology, Siriraj Hospital.

Materials and Methods: Medical records of 6,862 patients referred to our clinic between January 1992 and December 2021for patch testing were reviewed.

Results: The number of patients patch tested increased and reached a peak of 600 patients/year in 2019 before the COVID-19 pandemic.  The most frequently used series was baseline, while the most used specific series was cosmetics. The overall positivity rate was 69%. The highest positivity rate was in the cosmetics series (70.2%). Nickel sulfate was the most common contact allergen found (24.2%).

Conclusion:  Our patch test service has been growing in the last 30 years.  The series of allergens used for patch testing has been amended every few years to be up-to-date with current global trends of contact allergies. Continual surveillance of contact prevalence and periodic updating of those series are necessary to enhance our ability to detect culprit contact allergens, which could help us improve care of our patients.
Epidemiology of injury related disabilities in a selected district in Bangladesh: A cross-sectional study
Authors: Mashreky Saidur Rahman , Rahman AKM Fazlur , Moniruzzaman Mohammad , Zaman M Mostafa
Published: February 2023

Globally more than a billion people are living with disabilities. Injuries are one of the major causes of disabilities. A cross-sectional survey was conducted in 2009 to explore the epidemiology of injury-related disability in a district of Bangladesh. A total of 37,039 populations were interviewed in 8905 households both in the urban and rural area. Overall prevalence of injury-related disability was found 6.8 per 1000 population. Significantly higher rate was observed in the rural area compared to urban. Compare to female the rate was found significantly higher among male (8.5; 95% confidence interval: 7.3-9.9), compared to female (5.0; 95% CI: 4.1-6.2). Rates were found to increase with age, the highest prevalence was found among 60 years and above age group where the rate was 24.3 (95% CI: 19.0-30.6) per 1000 population. Compare to literate people illiterate people were found more vulnerable (odds ratio 3.1; 95% CI 1.7-5.9). The prevalence among illiterate was 13.4 (95% CI: 11.1-16.1) per 1000 population, and it was 3.8 (95% CI: 2.0-6.5) among higher secondary & above education level population. Falls caused more than 32% disabilities. Road traffic injuries, cuts, machine injuries, burns, and violence were the other common causes of injury disability. About 30% of the people identified with an injury-related disability mentioned that they don’t use public transports, and 65% of them mentioned this is because of their disability. About 37% people reported that they had lost their job because of the disability. Injury share the significant cause of disability in Bangladesh. Fall, road traffic injury and cuts are the common causes of injury-related disabilities.
Stunting and its associated factors in under-five children: evidence from Bangladesh Demographic and Health Survey 2014
Authors: Islam Md Sahidul , Islam Md Saimul , Chowdhury Rajib , Zaman Mohammad Mostafa
Published: February 2023

Impaired growth and development experienced by children, referred to as stunting, is a major impediment to human development. Although the Bangladesh economy has experienced high growth in recent decades, malnutrition still remains a public health problem. This study assesses the prevalence and risk factors associated with stunting among children under-five in Bangladesh. This analysis uses data from the Bangladesh Demographic and Health Survey 2014, a community-based cross-sectional study. A total of 6,965 children were enrolled in the study. The prevalence of stunting was 36.5% [95% confidence interval (CI): 34.8-38.3%] and 40.2% [95% CI: 37.4-43.1%] for children aged 0-59 months and 0-23 months respectively. Multivariate logistic regression revealed that the significant factors for stunting for children aged 0-59 months and 0-23 months were maternal working status, mother education, mothers age at childbirth, birth order, delivery mode, receiving antenatal clinic visit, media habits, perceived size of child at birth, child sex, children having had diarrhea in last two weeks, wealth and geographical region. In order to meet the nutrition indicators under zero hunger sustainable development goal and 2025 target of World Health Assembly, policy interventions are needed to reduce stunting specially focusing on eastern region of Bangladesh.
Lipid profile patterns in chronic obstructive pulmonary disease and its correlation with the severity of disease
Authors: Sarkar Gopal Chandra , Paul Susanta Kumar , Chakrabortty Rajashish , Ahmed Shamim , Islam Samprity , Paul Shipan Chandra , Dhar Debashish , Alam Kaoser , Choudhury Shah Ashiqur Rahman Ashiq , Rayhan Md Abu , Hossain A K M Mosharraf , Rahman Mohammed Atiqur
Published: February 2023

This cross-sectional study was conducted to determine the serum lipid profiles in chronic obstructive pulmonary disease (COPD) patients and its correlation with the severity of COPD in the Department of Respiratory Medicine at Bangabandhu Sheikh Mujib Medical University. A total of 100 spirometric-confirmed cases of COPD were included. Fasting blood samples for lipid profiles were collected. To identify the association between severity of COPD with lipid profiles Pearson’s correlation was used. Further multiple linear regression was done to identify the relation. The mean (standard deviation) age of the patients was 59.0 (10.7)years. The ratio of males and females was 19:1. The mean forced expiratory volume (liters) in 1 second (FEV1) was 55.1 (18.1). Most of the patients had stage II (48%) and stage III (36%) airflow obstruction. Plasma level of total cholesterol and triglyceride tend to increase, statistically non-significant, with stages of COPD. However, the association of plasma lipids becomes statistically significant with FEV1 when the effects of age, BMI, pack-year smoking, duration of illness are accounted in multiple linear regression analysis.
Relationship between gross motor function and magnetic resonance imaging findings in children with cerebral palsy
Authors: Ahmed Sanjida , Fatema Kanij , Kundu Gopen Kumar , Alam Syeda Tabassum , Sultana Rebecca , Neela Nahid , Sultana Sadia , Ferdous Zannatul , Paul Bikush Chandra , Sultana Rumana , Poddar Krishna Mohon , Akhter Shaheen
Published: February 2023

This cross-sectional study was carried out at the department of Pediatric Neurology, Institute of Pediatric Neurodisorder and Autism, Bangabandhu Sheikh Mujib Medical University, Dhaka with the aim to assess the relationship between gross motor function and MRI findings in children with cerebral palsy. The duration of the study was 12 months. All the cerebral palsy cases who met the selection criteria were enrolled. Detailed history taking and physical examination was done. The gross motor function of all cases was evaluated according to Gross Motor Function Classification System- Expanded and Revised (GMECS-E and R). Magnetic resonance imaging of brain was done in all enrolled patients and reports were evaluated. MRI findings were classified as maldevelopment, cortical and subcortical gray matter lesion, periventricular white matter injury, basal ganglia lesion, normal and other findings. A total of 45 children with cerebral palsy aged between 2 to 12 years were included in this study. Mean age of the children was 4.73 (+3.17) years. Male were 31 and female were 14 in number. Functionally majority patients were in GMFCS level IV (26.7%) and level V (20%). MRI findings were abnormal in 35 (77.78%) cases. Most common abnormal MRI finding was cortical and subcortical grey matter lesions 22 (48.9%). This study revealed that cortical and subcortical gray matter lesions were significantly associated with higher level of GMFCS (IV-V) (P=0.038) and maldevelopment of brain were also significantly associated with higher level of GMFCS (P=0.01). Normal MRI findings had significant association with mild to moderate GMFCS level (I-III) (P=0.012). From this study significant relationship was found between gross motor function and MRI of brain findings in children with cerebral palsy.
Analysis of the association between Epstein Barr virus infection and Hodgkin lymphoma
Authors: Jahan Jasmine Akhter , Islam S M Rashed Ul , Tanim Md Shafikul Alam , Ahmed Tasnim Binte , Alam Md Rabiul , Begum Ferdousy
Published: February 2023

Epstein Barr virus plays an important role in the pathogenesis of Hodgkin lymphoma. However, the frequency of its association in Bangladeshi people has not been widely studied. The aim of this study was to determine the association of Epstein Barr virus association in Hodgkin Lymphoma through detection of Latent Membrane Protein 1 by immunohistochemistry and serum Epstein Barr virus viral capsid antigen IgG antibody titer by serology. This was a cross-sectional study in purposively selected 45 histologically diagnosed cases of Hodgkin lymphoma at Bangabandhu Sheikh Mujib Medical University, Dhaka, during the period of March 2017 to December 2018. Latent membrane protein 1 was positive in 71.1% of cases of Hodgkin lymphoma. Among these positive cases, 96% of cases had significantly raised titer of serum Epstein Barr virus viral capsid antigen IgG antibody (P<0.0001 obtained by Fisher’s Exact test), which had a male predominance. Mixed cellularity classical Hodgkin lymphoma showed the highest positivity.
The ethics of plagiarism
Authors: Zaman M Mostafa
Published: February 2023

Abstract not available
Bangabandhu Sheikh Mujib Medical University Journal 2022;15(4):1
Elaboração de um plano de gestão farmacêutica de gases medicinais em um hospital universitário público de Belém
Authors: Silva Márcia Moraes Paulino da , Ribeiro Aline Farias , Silva Kezia Rayane Paulino da , Silva Marcos Valério Santos da
Published: February 2023

Objetivo: Desenvolver um plano de gestão, monitoramento e utilização de GM no HUJBB. Material e métodos: Trata-se de uma pesquisa de campo, do tipo exploratória e observacional de abordagem qualitativa, realizado um diagnóstico situacional, utilizando checklist com 28 itens conforme normas e legislações sobre os gases medicinais. Foi considerado como amostra, os locais que armazenam e distribuem os GM. Os resultados foram tratados com as ferramentas gerenciais, Matriz Swot e 5W2H, em fases distintas: identificação e análise dos dados. Resultados: Dos 28 itens, 9 itens não atenderam as normas e legislações: Área para armazenamento, recebimento dos GM, identificação de cilindros vazios, capacete de proteção das válvulas dos cilindros, rótulos dos cilindros, corrosão acentuada e alarmes de emergência nas unidades assistenciais. Através da Matriz Swot, foram observados os pontos fortes e fracos, as ameaças e as oportunidade e pelo método do 5W2H, foram propostos 7 planos de ação corretiva para as adequações dos itens. Conclusão: Este trabalho foi desenvolvido visando atender as necessidades de reorganizar a Gestão dos GM pelo Setor de Farmácia no HUJBB. Neste sentido, observou-se que ainda faltava ações por parte da instituição para que as normas e preceitos de qualidade fossem de fato realidade no hospital. Aguarda-se que os farmacêuticos adotem o instrumento informativo gerado por esta pesquisa, Manual de Orientação de Gases Medicinais, nas principais questões inerentes aos GM e ainda, poderá ser expandido a outros hospitais universitários, como uma ferramenta de gestão e monitoramento.
Effects of digital games training on hormonal responses and brain plasticity
Authors: Mitsea Eleni , Drigas Athanasios , Skianis Charalabos
Published: February 2023

Digital games are a ubiquitous part of almost all children’s and adolescents’ lives. At the same time gaming industry is ready to unlock new levels of growth in the coming years (Granik et al., 2014). A growing number of studies have already focused on the beneficial effects of digital games on various aspects of cognition and health. However, less emphasis has been given to the physiological biomarkers that operate in the background and cause various modifications in players’ mental and emotional states as well as their ability to be aware and take control over their decisions and actions. Hormones and neurotransmitters regulate homeostasis and determine to a significant extent humans’ health, state of mind, and self-awareness abilities. Neuroplasticity is now recognized as a crucial factor in acquiring new skills and abilities. The present study aims to investigate the impact of digital game-playing on hormone responses and neuroplasticity phenomena. To this objective, we conducted a literature review presenting the most representative experimental studies. The results showed that digital games have significant effects on hormone responses and neuroplasticity phenomena. Finally, we discuss the factors that may contribute to alterations in digital game players’ homeostasis. The findings of this review aim to contribute to the discussion regarding the design of targeted, novel game-based intervention tools that have the potential to improve homeostasis, drive positive neuroplasticity, accelerate metacognitive learning, and thereby promote mental and emotional well-being for both typical populations, but most importantly, for people with learning disabilities, mental and other disorders.
Diagnóstico tardio dos casos de varíola dos macacos nos serviços de saúde do Brasil: reflexos e impactos
Authors: Monte Gabriella Silva , Fernandes Giovanna Sobral , Chagas Júnior⁩ José Hérico Ferreira das , Palmeira José Olavo do Vale , Macêdo Laíza Cláudia Barbosa de , Tomaz Sara Brenda de Souza , Lima Tábata Loíse Cunha
Published: February 2023

Por várias décadas, a família do Poxvirus se mostrou como uma ameaça para diversos continentes, trazendo prejuízos à população europeia durante a Idade Média. Atualmente, algumas espécies emergentes vêm se tornando endêmicas, como o cenário da varíola dos macacos no serviço de saúde brasileiro, necessitando de esforços para erradicá-las. O trabalho em questão busca evidenciar as dificuldades da vigilância epidemiológica no sentido de diagnosticar precocemente os portadores do vírus. Foi utilizado como metodologia a análise literária dos mais recentes artigos e revistas sobre a temática, buscando correlacionar as dificuldades encontradas para seu diagnóstico. Assim, foi possível notar uma ameaça à saúde pública atual, haja vista ao desconhecimento sobre a doença da varíola do macaco, bem como ao descaso e fake news disseminada pela sociedade brasileira. Logo, medidas públicas precisam ser elaboradas para que os condicionantes desse diagnóstico tardio sejam minimizados no território brasileiro, visando avaliar as questões sociais, sexuais, econômicas e de classe que cercam a Monkeypox.
Estado nutricional e atitudes alimentares de pacientes bariátricos no contexto da pandemia de Covid-19 no Brasil
Authors: Ramos Larissa Oliveira , Conceição Weany Jacqueline Costa da , Gomes Bruna Gusmão , Figueira Marcela de Souza , Gomes Daniela Lopes , Costa Vanessa Vieira Lourenço
Published: February 2023

O presente estudo buscou testar a associação entre o estado nutricional e atitudes alimentares de pacientes bariátricos no contexto da pandemia de Covid-19 no Brasil. Trata-se de um estudo transversal, descritivo, analítico, on-line, com 412 indivíduos, distribuidos em 21 estados brasileiros, o estudo foi realizado após aprovação do Comitê de Ética e contemplou como público alvo indivíduos do sexo feminino ou masculino, com idade igual ou superior a 18 anos, que realizaram cirurgia bariátrica, e que aceitaram os termos da pesquisa. Foi utilizada a estatística descritiva (média, desvio padrão e frequência). Foi aplicado o teste de qui-quadrado de Pearson para testar a associação entre variáveis categóricas, com análise dos resíduos ajustados para identificar quais categorias estavam associadas.  Para todas as análises foi considerado o nível de significância estatística de p<0,05. Foram usados dados sócio demográficos: sexo, escolaridade, renda familiar, moradia, tempo de cirurgia, técnica cirúrgica, IMC e questionário EAT-26. Os resultados apresentaram indivíduos de maior participação o público feminino, com escolaridade de ensino médio completo e renda de um a três salários mínimos, tais fatores apresentaram associação ao desenvolvimento de atitudes alimentares o Bypass gástrico e os indivíduos submetidos entre três e seis meses de procedimento e o score total do EAT-26 pré-cirúrgico de valor 0,47 apresentaram correlação positiva para TA. Nesse sentindo, o acompanhamento multidisciplinar e nutricional de forma contínua é fundamental para garantir o sucesso do procedimento bariátrico.
Perfil clínico e sociodemográfico de crianças com paralisia cerebral participantes de um programa de estimulação psicomotora em um hospital de reabilitação
Authors: Teixeira Tiago de Matos , Sousa Thalita Costa de , Assunção Jeane Rodella
Published: February 2023

A Paralisia Cerebral (PC) pode ser definida como um grupo de desordens do movimento e postura, causando limitação na execução de ações do indivíduo, que são atribuídos a distúrbios não progressivos que ocorreram no desenvolvimento cerebral fetal ou infantil. Existem diversas possibilidades de intervenção em crianças com PC, buscando melhoria da função, dentre elas a Psicomotricidade. Esta pode ser definida como a relação entre o pensamento e a ação, envolvendo a emoção. Dada a importância da utilização da prática psicomotora em crianças com PC, este estudo fornecerá informações importantes para a compreensão do perfil destes pacientes e a partir daí traçar novas possibilidades de estimulação para esta população. Objetivo: Analisar o perfil clínico e sociodemográfico de crianças com PC que participaram de um programa de estimulação psicomotora em um hospital de reabilitação física. Método: Trata-se de uma análise documental, com estatística descritiva de crianças com PC que participaram de grupos de Estimulação Psicomotora na Rede SARAH de Hospitais de Reabilitação – Unidade Salvador/BA, entre 2016 e 2020. Resultados: Neste estudo, observou-se predomínio de pacientes com PC do gênero masculino, idade entre 3 e 5 anos, procedentes de Salvador, GMFCS nível I, tipo espástico hemiplégico. Conclusão: Os achados deste estudo são relevantes para a sociedade acadêmica, considerando-se a escassez de estudos envolvendo PC e Psicomotricidade. Além disto, apontam para uma nova possibilidade de intervenção por parte dos profissionais de saúde, caracterizando-se como uma parte importante do processo de reabilitação desses indivíduos.
Evaluation of the adjuvant effect of topic Bach floral in the clinical response to non-surgical periodontal treatment in patients with type 2 diabetes: pilot study
Authors: Carmo Raquel Alves do , Paula Camila Possal de , Cörner Ana Carolina Organista , Camargo Gabriela Alessandra da Cruz Gahardo
Published: February 2023

Objective: To evaluate the clinical response of periodontal tissues after periodontal therapy associated with the use of Bach Flower (Rock Rose gel) in participants with type 2 diabetes mellitus. Methodology: This randomized, doble-blind, split-mouth, single-center, placebo-controlled clinical trial selected 20 participants with moderate, severe, or advanced periodontitis (stage II, III, and IV). They were divided into groups, where group 1 received Floral Rock Rose gel and group 2, saline gel. All groups received conventional periodontal treatment characterized by scaling and root planing before gel application. Clinical evaluation was performed using periodontal clinical parameters: Plaque Index (PI), Gingival Index (GI), probing depth (PPD), gingival recession (GR), and Clinical Insertion Level (CAL). Biometric parameters and hematological parameters were also evaluated. All clinical and laboratory parameters were obtained at baseline and after three months. Results: There was an improvement in periodontal clinical parameters before and after treatment in both groups (P<0.05). There was no statistically significant difference between the intervention, control, and floral groups (P>0.05). Conclusion: The periodontal treatment performed with Rock Rose adjuvant gel (Bach Flower) was safe, efficient, and promoted the improvement of periodontal clinical parameters. However, it did not show superior results to conventional periodontal therapy.
Bioestimulante Ascophyllum nodosum na cultura do milho
Authors: Souza Luiz Paulo de , Franco Júnior Kleso Silva , Ribeiro Vinícius Muniz , Brigante Giselle Prado
Published: February 2023

Em busca de uma melhor produção agrícola, agricultores buscam novas tecnologias e dentre essas uma muito utilizada são os bioestimulantes, que são agroquímicos que podem promover diversos benefícios nas plantas cultivadas. Os bioestimulantes à base de extratos de algas da espécie Ascophyllum nodosum vem sendo amplamente comercializados, por apresentarem respostas relevantes na produção de diferentes culturas, principalmente quando estas estão sujeitas a cultivos em ambientes em condições de estresses. Estes produtos promovem aumento na absorção de nutrientes e água pelas plantas, além de influenciar na atividade hormonal. Objetivou-se avaliar os efeitos de diferentes doses do bioestimulante à base de extratos de algas da espécie Ascophyllum nodosum, aplicado via foliar, na cultura do milho. A pesquisa foi realizada entre março e julho de 2022, em Carmo do Rio Claro-MG, conduzida em Delineamento de Blocos Casualizados (DBC) com 5 tratamentos (doses de 0, 50, 100, 150 e 200 mL.ha-1 do bioestimulante) e 7 repetições, totalizando 35 unidades experimentais. Foram analisados os seguintes parâmetros: diâmetro de colmo, altura das plantas, comprimento de raiz, comprimento das folhas, largura das folhas, peso de mil grãos, produção em 200 m² e a produção em Kg.ha-1. A aplicação do bioestimulante à base de extratos de algas da espécie Ascophyllum nodosum (produto comercial Acadian) obteve resultados significativos no crescimento e desenvolvimento das plantas de milho, acarretando em incrementos significativos em produtividade de grãos, sobretudo quando aplicado na dose de 200 mL.ha-1.
Inteligência Espiritual: Uma questão de inteligência!
Authors: Fidelis Andréa Cristina Fermiano , Formiga Nilton S. , Fernandes António Jorge
Published: February 2023

A inteligência espiritual tem assumido uma ambivalência referente a sua pertença nos estudos da inteligência humana ou filosófica. Para responder a esta questão, o presente estudo tem como objetivo o desenvolvimento de uma pesquisa teórica através da abordagem bola de neve, sobre os dois temas que a sustentam, a saber: a espiritualidade e a inteligência. O estudo desenvolve elementos teóricos que contribuam para as discussões em torno da inteligência espiritual, especialmente, no que se refere a tradução do termo na área da psicologia e da filosofia. Neste contexto, o quanto a espiritualidade diz respeito as reduções as crenças religiosas, teoricamente, têm atribuído à inteligência espaços teóricos e empíricos de avaliação geral ou múltipla, bem como, hereditária ou aprendida. De forma geral, reflete-se o tema em questão numa abordagem da Inteligência espiritual quanto capacidade cognitiva inerente a todos os indivíduos, que precisa de estímulos externos para seu desenvolvimento.
Metodologias de ensino no ensino remoto no contexto pandêmico 2020-2021
Authors: Magalhães Victor Amaral , Oliveira Ângela Maria Gonçalves de
Published: February 2023

Este trabalho descreve a experiência de uma observação de natureza reflexiva realizado na escola estadual Álvaro Maia, apresenta um recorte da realidade da pesquisa que está sendo desenvolvida no Programa de Pós Graduação em Ensino de Ciências e Humanidades (PPGECH) da Universidade Federal do Amazonas – Instituto de Educação Agricultura e Ambiente (UFAM-IEEA) que também é uma das seções da dissertação que analisou as metodologias utilizadas durante o ensino remoto no contexto da pandemia do coronavírus (COVID-19) 2020-2021, nosso objetivo foi fazer um comparativo entre as metodologias de ensino tradicionais, que a escola utilizava e as metodologias de ensino ativas necessárias para esse modelo de ensino. Para tanto se utilizou uma abordagem de pesquisa participante já que o autor estaria inserido dentro do contexto da pesquisa, no seu próprio ambiente de trabalho e optou-se pela técnica de observação que seria o instrumento de coleta de dados adequado escolhido para a pesquisa. Fazendo uma revisão na literatura o apanhado forneceu o embasamento necessário para a discussão das ideias e análise crítica dos dados observados e foi possível constatar o grande contraste existente entre a utilização de metodologias durante o período do ensino remoto nesta escola.
Assistência de enfermagem na unidade coronariana a pacientes submetidos à revascularização do miocárdio
Authors: Silva Karina de Jesus Oliveira da , Alcântara Ricardo Dias , Costa Kemelly Melissa Azevedo da , Pinheiro Hellem Cristina da Silva , Silva Ana Beatriz de Sena , Silva Maria Suzane Silva e , Furtado Micaela Vitória Costa , Ribeiro Márcio Alves
Published: February 2023

A revascularização do miocárdio é um dos procedimentos mais realizados para a correção das isquemias que são causadas pela obstrução de artérias coronarianas. A gravidade no quadro dos pacientes que são submetidos a cirurgia de revascularização do miocárdio tem aumentado consideravelmente nos últimos anos. O objetivo deste estudo é descrever a assistência da equipe de Enfermagem a pacientes submetidos à Revascularização do Miocárdio em uma Unidade Coronariana de Belém-Pará. Os dados desta pesquisa científica foram coletados por meio de uma entrevista, com questionário semiestruturado com 10 enfermeiras que atuam em um hospital de referência cardiológica da cidade de Belém do estado do Pará referente ao ano de 2021, no setor da unidade coronariana. Este estudo se enquadra como uma pesquisa descritiva e qualitativa. Pode evidenciar o planejamento da sistematização da assistência de enfermagem ao paciente submetido a revascularização do miocárdio, descrever e identificar a assistência prestada pela equipe de enfermagem a este perfil de paciente.