Malignant glaucoma treated by low-dose laser cycloplasty: a 1-year multicenter prospective non-comparative study
Authors:   Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Lin Hai-Shuang , Zheng Xuan-Li ,   Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Wang Ji-Bing ,   Weifang Eye Hospital, Weifang 261000, Shandong Province, China, Fan Su-Jie ,   Handan Eye Hospital, Handan 056000, Hebei Province, China, Wu Zuo-Hong ,   Aier Eye Hospital (Wuhan), Wuhan 430061, Hubei Province, China, Cheng Su-Mian ,   Hebei Eye Hospital, Xingtai 054001, Hebei Province, China, Zhao Li-Jun ,   The Third People's Hospital of Dalian, Dalian 116033, Liaoning Province, China, Cai Qin-Hua ,   First Affiliated Hospital of Suzhou University, Suzhou 215031, Jiangsu Province, China, Zhang Shao-Dan ,   National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; Glaucoma Research Institute, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China, Liu Shan-Shan ,   Weifang Eye Hospital, Weifang 261000, Shandong Province, China, Lyu Ai-Guo ,   Handan Eye Hospital, Handan 056000, Hebei Province, China, Zhang Ying ,   Aier Eye Hospital (Wuhan), Wuhan 430061, Hubei Province, China, Chen Hong ,   Hebei Eye Hospital, Xingtai 054001, Hebei Province, China, Jiang Dan-Ni ,   The Third People's Hospital of Dalian, Dalian 116033, Liaoning Province, China, Li Wu-Liang ,   Ningbo Eye Hospital, Ningbo 315100, Zhejiang Province, China, Congdon Nathan ,   Centre for Public Health, Queen's University Belfast, Belfast BT7 1NN, UK; Orbis International, New York, USA, Tham Clement C ,   Department of Ophthalmology and Visual Sciences, the Chinese University of Hong Kong, Hong Kong SAR 999077, China, He Ming-Guang ,   Centre for Eye Research Australia, University of Melbourne, Royal Victorian Eye and Ear Hospital, East Melbourne 3000, VIC, Australia, Liang Yuan-Bo ,   National Clinical Research Center for Ocular Diseases, Eye Hospital, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China; Glaucoma Research Institute, Wenzhou Medical University, Wenzhou 325027, Zhejiang Province, China
Published: June 2024

AIM: To report a one-year clinical outcomes of low-dose laser cycloplasty (LCP) among malignant glaucoma patients.
METHODS: In this prospective, multicenter, non-comparative clinical study, participants with malignant glaucoma were recruited and underwent LCP at eight ophthalmic centers in China. Patients were followed up at 1wk, 1, 3, 6, and 12mo. Intraocular pressure (IOP), number of glaucoma medications, anterior chamber depth (ACD), and complications were recorded. Anatomical success was defined as the reformation of the anterior chamber based on slit-lamp biomicroscopy. Recurrence was defined by the presence of a shallow or ?at anterior chamber after initial recovery from treatment.
RESULTS: A total of 34 eyes received LCP. Mean IOP and medications decreased from 36.1±11.5 mm Hg with 3.3±1.5 glaucoma medications pre-treatment to 20.9±9.8 mm Hg (P&#x003C;0.001) with 2.9±1.6 medications (P=0.046) at 1d, and 17.4±6.7 mm Hg (P&#x003C;0.001) with 1.3±1.7 medications (P&#x003C;0.001) at 12mo. The ACD increased from 1.1±0.8 mm at baseline to 1.7±1.0 mm and to 2.0±0.5 mm at 1d and 12mo, respectively. A total of 32 (94.1%) eyes achieved initial anatomical success. During follow-up, 2 (5.9%) eyes failed and 8 (23.5%) eyes relapsed, yielding a 12-month anatomical success rate of 64.3%. Complications including anterior synechia (8.82%), choroidal/ciliary detachment (5.88%) and hypopyon (2.94%) were observed within 1wk.
CONCLUSION: LCP is simple, safe, and effective in reforming the anterior chamber in malignant glaucoma.