bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of different immunoassays for the quantitative detection of Epstein–Barr virus capsid antigen immunoglobulin A using a candidate reference
Authors: Chen Hao , Zhong Qiaohua , Wu Xiaobin , Ding Yanling , Chen Qi , Xue Ning , Chen Weizhong , xing shan , xu yiwei
Published: July 2019

Background

As Epstein–Barr capsid antigen (VCA) immunoglobulin A (IgA) detection is widely used for nasopharyngeal carcinoma (NPC),many immunoassays are available for VCA- IgA detection.

Methods

We evaluated the performance of different immunoassays for the quantitative detection of VCA-IgA. Twenty NPC patients were detected VCA-IgA by four ELISA kits and twochemiluminescent immunoassays(CLIA) kits using the reference as a calibration curve. The performance of six kits were evaluated, and the quantitative results were compared.

Results

Our results shown the reference has good linearity in different kits. Without reference, the difference of total CV (from 3.98% to 43.11%) and Within-run CV(from 2.47% to 19.66%) was large in 6 kits. The positive and negative coincidence rate between 6 kits and IFA for NPC diagnosis was 75% overall agreement, but there was a difference among the six kits ranged from 55%-90%. Concentration of samplesdivided into three categories was shown significant difference in certain subgroup of 6 kits. Almost all assays gave a correlation coefficient lower than 0.80, except for Antu and Beier kit and Tarcine kit and New Industries kit.

Conclusions

The reference serum may be used as a reference standard and better compared results from different methods/laboratories.Despite the use of our reference, the quantitative results of each kit are still quite different.We should try to unify the diversity between different antigens to promote the development of VCA-related research in the further.
Free Fatty acids receptors (FFAR2 and FFAR3) control cell proliferation by regulating cellular glucose uptake
Authors: Aziz Mohammad , Mahri Saeed Al , Alghamdi Amal , AlAkiel Maaged , Aujan Monira Al , Mohammad Sameer
Published: July 2019

Background

Colorectal cancer is a worldwide problem which has been associated with changes in diet and lifestyle pattern. As a result of colonic fermentation of dietary fibres, short chain free fatty acids are generated which activate Free Fatty Acid Receptors 2 and 3 (FFAR2 and FFAR3). FFAR2 and FFAR3 genes are abundantly expressed in colonic epithelium and play an important role in the metabolic homeostasis of colonic epithelial cells. Earlier studies point to the involvement of FFAR2 in colorectal carcinogenesis.

Methods

Transcriptome analysis console was used to analyse microarray data from patients and cell lines. We employed shRNA mediated down regulation of FFAR2 and FFAR3 genes which was assessed using qRT-PCR. Assays for glucose uptake and cAMP generation was done along with immunofluorescence studies. For measuring cell proliferation, we employed real time electrical impedance based assay available from xCelligence.

Results

Microarray data analysis of colorectal cancer patient samples showed a significant down regulation of FFAR2 gene expression. This prompted us to study the FFAR2 in colorectal cancer. Since, FFAR3 shares significant structural and functional homology with FFAR2, we knocked down both these receptors in colorectal cancer cell line HCT 116. These modified cell lines exhibited higher proliferation rate and were found to have increased glucose uptake as well as increased level of GLUT1. Since, FFAR2 and FFAR3 signal through G protein subunit (Gαi), knockdown of these receptors was associated with increased cAMP. Inhibition of PKA did not alter the growth and proliferation of these cells indicating a mechanism independent of cAMP/PKA pathway. Conclusion: Our results suggest role of FFAR2/FFAR3 genes in increased proliferation of colon cancer cells via enhanced glucose uptake and exclude the role of protein kinase A mediated cAMP signalling. Alternate pathways could be involved that would ultimately result in increased cell proliferation as a result of down regulated FFAR2/FFAR3 genes. This study paves the way to understand the mechanism of action of short chain free fatty acid receptors in colorectal cancer.
A Randomised Controlled Trial on Analgesic Effect of Repeated Quadratus Lumborum Block Versus Continuous Epidural Analgesia Following Laparoscopic Nephrectomy
Authors: Aditianingsih Dita , Pryambodho Pryambodho , Anasy Naufal , Tantri Aida Rosita , Mochtar Chaidir Arif
Published: July 2019

Background

Epidural analgesia as the pain management for abdominal surgery has side effects such as paraesthesia, hypotension, haematomas, and impaired motoric of lower limbs. The quadratus lumborum block (QLB) has potential as an abdominal truncal block, however, the analgesic efficacy of QLB compared to epidural analgesia is unknown. This prospective randomised controlled study compared the effectiveness of QLB on postoperative opioid requirement and pain intensity with the epidural analgesia technique in transperitoneal laparoscopic nephrectomy.

Methods

Sixty-two patients underwent laparoscopic donor nephrectomy were randomised to receive QLB (n=31) or continuous epidural (n=31). The QLB group received bilateral QLB with 0.3–0.4 ml/kg bupivacaine 0.25% and the epidural group received bupivacaine 0.25% 6 ml/h for intraoperative analgesia. As postoperative analgesia, the QLB group received repeated bilateral QLB and the epidural group received the decreased dosage of bupivacaine 0.125% 6 ml/h for 24 hours after surgery completion. The primary outcome was cumulative morphine requirement 24 hours postoperatively. Secondary outcomes included haemodynamic changes, postoperative pain scores, sensory block coverage, Bromage score, postoperative nausea and vomiting (PONV), and duration of urinary catheterisation.

Result

Postoperative cumulative morphine requirement, pain scores, PONV and Bromage score were not significantly different between the QLB and epidural group. The QLB affected T9–L2, continuous epidural block affected T8–L3 dermatomes. Duration of urinary catheterisation was shorter (p < 0.001) in the QLB group. The mean arterial pressure (MAP) measured at 24 hours after surgery was lower in the epidural group (p = 0.001).

Conclusion

The repeated QLB had similar cumulative 24-hour morphine requirement, higher MAP, similar postoperative pain scores, similar PONV and degree of motor and sensory blockade, and shorter urinary catheterisation duration, compared with continuous epidural analgesia after transperitoneal laparoscopic nephrectomy.

Trial Registration
ClinicalTrial.gov NCT03520205 retrospectively registered on May 9th 2018.

Keywords: epidural analgesia; laparoscopic nephrectomy; postoperative analgesia; patient-controlled analgesia; quadratus lumborum block.
Application of fuzzy cognitive map-based TRIZ inventive principles for sustainable sediment management in dam reservoirs
Authors: Khakzad Hamid
Published: July 2019

The present paper contributes to the development and discussion on fuzzy cognitive map (FCM)-based theory for inventive problem solving (TRIZ) for sustainable sediment management in reservoirs. FCM combines aspects of fuzzy logic, neural networks, semantic networks, expert systems, and nonlinear dynamical systems. TRIZ is a constructive methodology that includes practically reproducible models and methods that allow the development of new inventions as well as the teaching of the process, the models, and the methods of creating inventions. A proposed approach in this paper is an improvement methodology that is designed to bring about rapid improvements/changes to processes by defining and implementing the changes that can be quickly identified and easily implemented, thereby reducing the cost and time to bring about improvement and change in reservoirs. Results of this study provide a road map for how to introduce FCM and TRIZ into local sustainable sediment management with consideration of technical and executive requirements, economic factors, social welfare, and environmental impacts.
Bioactive Proteins in Channa striata Promote Wound Healing through Angiogenesis and Cell Proliferation
Authors: Kwan Soon Hong , Abdul Aziz Nur Hidayah Kaz , Ismail Mohd Nazri
Published: July 2019

Background:

Channa striata are speculated to contain bioactive proteins with the ability to enhancing wound healing. It is commonly consumed after surgery for a faster recovery of the wound.

Objective:

To identify the bioactive proteins and evaluate their ability in cell proliferation and angiogenesis promotion.

Material and Methods:

Freeze-Dried Water Extracts (FDWE) and Spray-Dried Water Extracts (SDWE) of C. striata were tested with MTT assay using EA.hy926 endothelial cell line and ex-vivo aortic ring assay. Later the proteins were fractionated and analysed using an LC-QTOF mass spectrometer. The data generated were matched with human gene database for protein similarity and pathway identification.

Results:

Both samples have shown positive cell proliferation and pro-angiogenic activity. Four essential proteins/genes were identified, which are collagen type XI, actin 1, myosin light chain and myosin heavy chain. The pathways discovered that related to these proteins are integrin pathway, Slit-Robo signalling pathway and immune response C-C Chemokine Receptor-3 signalling pathway in eosinophils, which contribute towards wound healing mechanism.

Conclusions:

The results presented have demonstrated that C. striata FDWE and SDWE protein fractions contain bioactive proteins that are highly similar to human proteins and thus could be involved in the wound healing process via specific biological pathways.
Achievements in Cancer Research and its Therapeutics in Hundred Years
Authors: Shastri Sravanthi , Chatterjee Bhaswati , Thakur Suman S.
Published: July 2019

Cancer research has progressed leaps and bounds over the years. This review is a brief overview of the cancer research, milestone achievements and therapeutic studies on it over the one hundred ten years which would give us an insight into how far we have come to understand and combat this fatal disease leading to millions of deaths worldwide. Modern biology has proved that cancer is a very complex disease as still we do not know precisely how it triggers. It involves several factors such as protooncogene, oncogene, kinase, tumor suppressor gene, growth factor, signalling cascade, micro RNA, immunity, environmental factors and carcinogens. However, modern technology now helps the cancer patient on the basis of acquired and established knowledge in the last hundred years to save human lives.
Diseño de un curso MOOC como estrategia para fortalecer las sinergias comunitarias en las zonas rurales
Authors: Solarte Montoya Mayra Roxana , Grass Ramírez José Fernando
Published: July 2019

Los territorios rurales en Colombia se caracterizan por ser escenarios interculturales, este aspecto plantea retos a la formación profesional tradicional, ofreciendo alternativas como el proyecto MOOCMenTes, en el cual se aprovechan espacios virtuales y el tránsito a la Educación Superior desde contextos rurales y diversos. Este artículo evidencia una estrategia para fortalecer las sinergias comunitarias en las zonas rurales, el diseño del curso MOOC “Construcción colectiva de mercados agroecológicos y solidarios”, utilizando la herramienta MOOC Canvas para el diseño del curso, y su validación a través de una herramienta metodológica de Investigación-Acción-Participativa (IAP). En esta experiencia se logró afianzar una modalidad de formación como son los MOOCs, con una temática pertinente hacia los territorios rurales, como dinamizadora de la educación rural.
Fisiología del cultivo de yuca en el bosque seco tropical de Sucre – Colombia
Authors: Santos Joseth A. , Narváez Lainer , Salcedo Saula M. , Acevedo Alba N. , Mercado Luis C. , Salcedo Jairo G.
Published: July 2019

La especie  M. esculenta presenta gran variabilidad genética que dificulta su estudio debido a que debe ser evaluada no solo por su comportamiento varietal sino también por su respuesta al ambiente donde se produce. Para esta investigación se evaluó el comportamiento fisiológico de yuca en tres de las variedades más cultivadas en el departamento de Sucre: MCOL 2066 (Chirosa: uso industrial y comestible), MCOL 2215 (Venezolana: comestible) y M-Tai 8 (M-Tai: uso industrial), bajo la oferta ambiental del bosque seco tropical, se utilizó un diseño en bloques completos al azar con tres repeticiones. Se evaluó altura de planta (AP), diámetro de tallo (DT), número de hojas (NH), diámetro de raíces tuberosas (DR), fotosíntesis (PN), conductancia estomática (GS), transpiración (E) acumulación y distribución de masa seca e índice de cosecha (IC). Las evaluaciones se llevaron a cabo a los 90, 270, 315 y 360 días después de la siembra (DDS). La variedad M-Tai presentó los resultados más favorables un crecimiento y desarrollo más precoz en los primeros estadios del cultivo (90 DDS) expresado en un mayor porte y mayor acumulación de biomasa con una media de 198,51 gr de materia seca. En la fecha de cosecha 270, 315 y 360 DDS no se observó diferencias entre variables de intercambio gaseoso y acumulación y distribución de biomasa, presentando valores promedios de 130 mmol H2O m-2s-1, 17,87 µmoles CO2 m-2 s-1 y 1,99 mmol H2Omm-2 s-1 para GS, PN y E respectivamente, y con valoresalrededor de un 55% para IC.
RECOMMENDATIONS OF THE DEVELOPMENT OF INTERPROFESSIONAL EDUCATION IN A FACULTY OF MEDICINE
Authors: Muktamiroh Hikmah , Irmarahayu Agneta , Setyaningsih Yuni
Published: July 2019

Background: In the Competence Standards of Indonesian Doctor (SKDI) which will ratify, interprofessional communicationand collaboration are competencies that Indonesian doctors mustown. Therefore, the implementation of interprofessional education (IPE) is a must for medical education institutions. Medical Faculty of the Universitas Pembangunan Nasional Veteran Jakarta (FK UPNVJ) has not specifically built the IPE module but has introduced aspects for interprofessional collaboration in the curriculum. Evaluation of the perceptions and readiness of students about IPE learning in students of academic year 2, 3 and 4 using the Indonesian version of The Interdisciplinary Education Perception Scale (IEPS) and Readiness for Interprofessional Learning Scale (RIPLS) showed that there were no differences in IEPS scores on student years 2nd and 3rd but decreased in 4th year students and the best RIPLS scores in the 3rd year and decreased in the 4th year. Against these results, intervention recommendations are needed to obtain results following the demands and expectations.Objectives: This study aims to obtain recommendations made based on disscussion and analysis of teaching staff of the FK UPNVJ about the results of evaluating perceptions and readiness of the FK UPNVJ at the academic stage.Methods: The research was a phenomenological qualitative research. Data collection through the opened-ended on Focus Group Discussion and in-depth interviews with teaching staff of the FK UPNVJ.Results: The teaching staff stated the importance of implementing interprofessional education by forming a curriculum. The curriculum must be more focused on interprofessional communication and collaboration since the academic stage. This implementation can be done well if get full support from the dean and the rector. The teacher staff, dean and rector’s commitment to the implementation of interprofessional education is the demand as well as the hope for the implementation of interprofessional educationConclusion: The obligation to implement interprofessional education is not natural, but it is not impossible. Several things can be done so that doctors graduating from FK UPNVJ can own communication and interprofessional collaboration competencies.
A better strategy using barbed sutures for wound closure in total knee arthroplasty
Authors: Xin Wen-Qiang , Zhao Yan , Wang Hao , Wu Jun , Wang Hong-Yu , Gao Yi-Kuan , Yang Xin-Yu
Published: July 2019

Aim:
The purpose of this study was to conduct a meta-analysis to systematically compare the clinical outcomes between knee barbed sutures (KBS) and knee traditional sutures (KTS) for wound closure in total knee arthroplasty (TKA).
Method:
This study retrieved potential academic articles comparing the clinical outcomes between KBS and KTS in TKA from the MEDLINE database, the PubMed database, the EMBASE database and the Cochrane Library. The reference articles for the identified studies were carefully reviewed to ensure that all available documents were represented in the study.
Results:
A total of 14 articles (eight randomized controlled trials [RCTs], six non-RCTs) were involved in our study. The overall participants of barbed Sutures group were 1255, whereas it was 1247 in the traditional sutures. Our meta-analysis showed that KBS is preferable for wound closure of TKA as its shorter lower total cost (weighted mean difference [WMD] = -276.281, 95% CI = -480.281 to -72.280; p = 0.008) and wound closure time (WMD = -4.895,95% CI = -6.105 to -3.685; p < 0.001). However, there was no difference in any complications (p = 0.572), wound complications (p = 0.550), superficial infection (p = 0.918), deep infection (p = 0.654), wound dehiscence (p = 0.649), suture abscess (p = 0.939), arthrofibrosis (p = 0.970), needle sticks (p = 0.158), suture breakage (p = 0.371) and knee society scores (KSS; p = 0.073).
Conclusion:
The use of KBS in TKA is associated with significantly shortened wound closure times and total closure cost without increased risk of intraoperative needle sticks and suture breakage and postoperative incision complications. Given the relevant possible biases in our study, adequately powered and more RCTs with long-term follow-up are needed to compare the efficacy and safety between KBS and KTS.
Agnotología: El estudio de la ignorancia y la educación médica
Authors: Sánchez-Mendiola Melchor
Published: July 2019

En el contexto actual es inevitable reflexionar sobre lo que le está ocurriendo a la comunidad académica internacional, cada vez más presionada por una cadena de decisiones y eventos que, de forma directa o indirecta, están afectando su labor y credibilidad ante la sociedad en general.
Objetivo de la inflación: evaluación de la evidencia
Authors: Angeriz Álvaro , Arestis Philip
Published: July 2019

El objetivo de inflación (IT, por sus siglas en inglés), diseñado para controlar la inflación, ha estado presente desde inicios de los años noventa. En trabajos recientes se afirma que un número significativo de países adoptaron esta estrategia y que este número sigue creciendo. Por ejemplo, Sterne (2002, Apéndice A) sugiere que 54 países siguieron una forma u otra de IT en 1998, en comparación con sólo 6 países en 1990. Un estudio más reciente (IMF 2005) sugiere que 21 países (8 desarrollados y 13 emergentes) tienen, de forma clara, un objetivo de inflación, siguiendo una estrategia de IT completamente desarrollada (FFIT, por sus siglas en inglés). En efecto, varios países están considerando seriamente la adopción de esta estrategia. Diversos estudios han intentado examinar empíricamente el grado y la extensión del impacto de la estrategia de IT en la inflación en diversos países. A continuación revisamos esta literatura y concluimos que la evidencia empírica disponible produce resultados mixtos, aunque el caso para los países en desarrollo es menos claro.
Impacto de los escenarios post-Kyoto en España
Authors: González Eguino Mikel
Published: July 2019

En la úlima década, el cambio climático (CC) de ha convertido en una cuestión clave en la agenda política internacional. Existe un consenso amplio en la comunidad científica sobre la necesidad de reducir fuertemente los gases de efecto inverndero (GEIs) si queremos controlar el aumento de las temperaturas (IPCC 2007). Lograr un acuerdo sobre los niveles globales de reducción de GEIs es una labor compleja. Para ello, es preciso primero estimar los beneficios y los costos de las distintas medidad alternativas, elegir entre un objetivo global y asignar, posteriormente, y entre los distintos países las cuotas de reducción de GEIs comenzaron a desarrollarse en la década de los años noventa, y han sido aplicados a nivel global (Nordhaus 1993), a nivel regional (Weyant 1999) y utilizando diversos tipos de modelos (Springer 2003). Más recientemente diversos trabajos se han centrado en cómo lograr una distribución equitativa de las cuotas entre países y a lo largo del tiempo (frankel 2008).
CHOQUES MACROECONÓMICOS EN LA AGRICULTURA. ALGUNA EVIDENCIA PARA LA ECONOMÍA ARGENTINA
Authors: Lanteri Luis N.
Published: July 2019

Este trabajo investiga las fuentes de las fluctuaciones en el producto agropecuario de la economía Argentina, empleando una propuesta de corrección de error vectorial estructural (SVEC por sus siglas en inglés) y datos trimestrales que abarcan el periodo 1993:1-2010:1. A tal efecto, se imponen restricciones de corto y de largo plazos al modelo de SVEC y se identifican cuatro choques estructurales: términos de intercambio, oferta, demanda (tipo de cambio real) y choques monetarios. Los resultados muestran que la principal fuente de las fluctuaciones en el producto en el largo plazo obedece a los choques de oferta (productividad) y en menor medida a los términos del intercambio.
ECONOMICS OF LAND USE DYNAMICS IN TWO MEXICAN COFFEE AGROFORESTS: IMPLICATIONS FOR THE ENVIRONMENT AND INEQUALITY
Authors: Baerenklau Kenneth A. , Ellis Edward A. , Marcos-Martinez Raymundo
Published: July 2019

Land use and land cover change have wide ranging implications for the environment and human welfare. This study analyzes both landscape and parcel level data to assess the causes and extent of deforestation in two Mexican coffee agroforests, as well as the likely environmental and welfare effects of policies designed to reduce tree cover loss. We find that shade coffee growers in Atzalan exhibit a relatively high elasticity of substitution between agricultural outputs: in response to low coffee prices, they have predominantly cleared their agroforestry parcels for production of tree crops. Shade coffee growers in Zozocolco exhibit a relatively low elasticity of substitution: agroforests were mostly either augmented with allspice trees or abandoned. Our policy simulations show that price supports for shade coffee would have larger effects on canopy preservation and welfare in Atzalan, even though Zozocolco is more marginalized.
Pengaruh Motivasi Kerja Terhadap Disiplin Kerja Karyawan Pada Hotel Permai Pekanbaru
Authors: Saputra Trio
Published: July 2019

The purpose of this study was to determine how much influence work motivation on employee work discipline at Permai Hotel Pekanbaru. In this study the authors used data analysis with Quantitative methods, namely data that can be calculated in the form of numbers obtained through questionnaires on respondents or the employee itself, and consists of Primary data and Secondary data. The results of the study based on regression analysis found that there was an effect of work motivation on employee work discipline positive correlation coefficient means having a unidirectional relationship. The better the motivation possessed by an employee, the higher the work discipline of the employee. Conversely, if the employee's work motivation is low then the work discipline will also be low, therefore the company leader, especially the hotel game will still provide motivation to employees to be able to improve work discipline.

Tujuan dari penelitian ini adalah untuk mengetahui seberapa besar pengaruh motivasi kerja terhadap disiplin kerja karyawan pada Hotel Permai Pekanbaru.Di dalam Penelitian ini penulis menggunakan analisa data dengan metode Kuantitatif, yaitu data yang dapat dihitung berupa angka-angka diperoleh melalui penyebaran angket penelitian terhadap responden atau karyawan itu sendiri, dan terdiri dari data Primer dan data Sekunder. Hasil penelitian berdasarkan analisis regresi ditemukan ada pengaruh motivasi kerja terhadap disiplin kerja karyawan koefisien korelasi positif artinya memiliki hubungan yang searah. Semakin baik motivasi yang dimiliki oleh seorang karyawan maka akan semakin tinggi disiplin kerja karyawan, Sebaliknya apabila motivasi kerja karyawan rendah maka disinlin kerja juga akan rendah, oleh karena itu pimpinan perusahaan khususnya hotel permai tetap memberikan motivasi kepada karyawan untuk dapat meningkatkan disiplin kerja.
Capital Intellectual Yang Mempengaruhi Kinerja Keuangan Dengan Menggunakan ROE Sebagai Indikator Pengukuran (Studi Pada BPD Sumatera Barat)
Authors: Kusuma Dewi Mike , Meirina Elsa
Published: July 2019

This study aims to determine how far the influence of intellectual capital on the financial performance of the Regional Development Bank of West Sumatra as the object of research. These financial performance measurement indicators use ROE, while intellectual capital is measured using VACA, VAHU, and STVA. Research data are time series. The period of financial statements taken is from 2015-2018. The financial statement data is taken monthly. Data is processed using SPSS data processing tools. Data analysis used multiple linear regression analysis. Based on the results of the study, VACA and VAHU had an effect on ROE, but STVA did not affect ROE. Simultaneously, intellectual variables have a positive influence on financial performance. With a very high level of determinant of 97.6%, intellectual capital affects the level of financial performance if based on ROE.

Penelitian ini bertujuan untuk mengetahui seberapa jauh pengaruh modal intelektual terhadap kinerja keuangan pada Bank Pembangunan Daerah Sumatera Barat sebagai objek penelitiannya. Indikator pengukuran kinerja keuangan ini menggunakan ROE, sedangkan capital intelektual diukur dengan menggunakan VACA, VAHU, dan STVA. Data penelitian bersifat time series. Jangka waktu laporan keuangan yang diambil adalah dari tahun 2015-2018. Data laporan keuangan tersebut diambil secara  per bulan. Data diolah dengan menggunakan alat pengolah data SPSS. Analisis data menggunakan analisis regresi linear berganda. Berdasarkan hasil penelitian, VACA dan VAHU berpengaruh terhadap ROE, namun STVA tidak mempengaruhi ROE. Secara simultan, variabel intelektual memiliki pengaruh positif terhadap kinerja keuangan. Dengan tingkat determinan yang sangat tinggi yaitu 97, 6%, capital intellectual mempengaruhi tingkat kinerja keuangan apabila berdasarkan ROE.
SUSTAINABILITY ANALYSIS OF WHITELEG SHRIMP POND AQUACULTURE AT JATIRENGGO VILLAGE, LAMONGAN REGENCY
Authors: Lusiana Evellin Dewi , Musa Muhammad , Mahmudi Mohammad , Arsad Sulastri , Buwono Nanik Retno
Published: July 2019

Whiteleg shrimp (Litopenaeus vannamei) is a fisheries commodity which has high economic value because of its high demand and easier cultivation. Lamongan regency is one of the minapolitan region in East Java Province, especially at Glagah district, Jatirenggo village which becomes the minapolist, with one of the superior commodities is whiteleg shrimp. The development of a certain village can be determined by village developing index or IDM which consists of three categories, they are left behind, developing, and advance village. Jatirenggo village has a village developing index (IDM) of 0.6080 which classified as developing category or category 2. Thus, in order to increase its status, the welfare of its people need to be considered. Whiteleg shrimp pond aquaculture can be one of the effort to increase the income of Jatirenggo’s. This study aims to analyze the sustainability of whiteleg shrimp aquaculture activity in Jatirenggo village according to ecology, socio-economic, technology-infrastructure, and institutional dimension. The used method was MDS Rapfish. The results showed that the whiteleg shrimp aquaculture in Jatirenggo village is classified as sustainable, or it means the situation in Jatirenggo village is suitable for a successful aquaculture. Thus, it can be expected to increase the income of the farmers.
Energy Consumption Between Routing and Bridging Protocol for Eco-Friendly Wireless Networks
Authors: Alhamri Rinanza Zulmy , Cinderatama Toga Aldila , Heriadi Agustono , Pradana Andika Kurnia Adi
Published: July 2019

The implementation of eco-friendly technology has been become an interesting field for sustainability. No exception with the implementation of wireless technology that used for developing networks infrastructure, it is necessary for saving the usage of energy. As a data forwarding protocol in a computer network, commonly there are two protocols that used for, which are routing and bridging protocol. Technically routing protocol has been confirmed that it is more effective and efficient than bridging protocol. However bridging protocol still becomes the popular protocol for data forwarding because it is easy to use. This research tried to test the energy consumption of the wireless network device that implementing between routing or bridging protocol. The wireless network device that used for this research was MikroTik router RB 433Ah. The data forwarding protocol that was tested consists of bridging, static routing, and RIP routing. Data traffic scenario that used for this research consisted of two scenarios which were HTML data access with packet size 256B and video streaming data access with packet size 1518B. Measuring the energy consumption referred to three parameters which were power consumption, CPU usage, and processor temperature. The result showed that for HTML data access scenario, the RIP routing protocol become the lowest energy consumption with power consumption reached 7.460 W, CPU usage 4.6 %, and processor temperature 38.133^C. While for video streaming scenario, generally the RIP routing protocol still become the lowest energy consumption with power consumption reached 7.567 W, CPU usage 7.33 %, and processor temperature 36.727^C.
Internet of Things Platform for Manage Multiple Message Queuing Telemetry Transport Broker Server
Authors: Wardana Aulia Arif , Rakhmatsyah Andrian , Minarno Agus Eko , Anbiya Dhika Rizki
Published: July 2019

This study proposed the Internet of Things (IoT) monitoring platform model to manage multiple Message Queuing Telemetry Transport (MQTT) broker server. The Broker is a part of the MQTT protocol system to deliver the message from publisher to subscriber. The single MQTT protocol that setup in a server just have one broker system. However, many users used more than one broker to develop their system. One of the problems with the user that use more than one MQTT broker to develop their system is no recording system that helps users to record configurations from multi brokers and connected devices. This can cause to slow the deployment process of the device because the configuration of the device and broker not properly managed. The platform built is expected to solve the problem. This proposed platform can manage multiple MQTT broker server and device configuration from different product or vendor. The platform also can manage the topic that connects to a registered broker on the platform. The other advantages of this platform are open source and can modify to a specific business process. After usability testing and response time testing, the proposed platform can manage multiple MQTT broker server, functional to use, and an average of response time from the platform page is not more than 10 seconds.
Tes DNA Sebagai Alat Bukti Pengganti Empat Orang Saksi (Analisis Qanun Aceh Nomor 6 Tahun 2014 tentang Hukum Jinayah)
Authors: Fadli Era
Published: July 2019

Terdapat dua alat bukti zina yang telah disepakati oleh ulama, yaitu pengakuan dan empat orang saksi. Dewasa ini, terdapat alat bukti lain yang dipandang akurat menetapkan seseorang berbuat zina, yaitu bukti test DNA. Qanun Aceh Nomor 6 Tahun 2014 Tentang Hukum Jinayat telah memasukkan test DNA sebagai alat bukti pengganti empat orang saksi. Pertanyaan yang timbul adalah: (1) Bagaimana latar belakang pembentukan Qanun Aceh Nomor 6 Tahun 2014 Tentang Hukum Jinayah? (2) Bagaimana penggunaan test DNA sebagai alat bukti dalam Qanun Jinayah? (3) Bagaimana tinjauan Hukum Islam terhadap Tes DNA sebagai alat bukti pengganti empat orang saksi? Penelitian ini dilakukan dengan pendekatan studi pustaka dengan metode analisis-yuridis. Hasil penelitian ini ada tiga: (1) Pembentukan Qanun Aceh Nomor 6 Tahun 2014 Tentang Hukum Jinayah dilatarbelakangi oleh beberapa faktor, yaitu masyarakat Aceh menginginkan adanya aturan yang jelas dan konstitusional tentang penegakan hukum, sebagai tindak lanjut dari keistimewaan yang diberikan oleh pemerintah pusat dalam menegakkan syari’at Islam khususnya di bidang penegakan hukum, terakhir sebagai representasi dari amanah Pasal 125 Undang-Undang Nomor 11 tahun 2006 tentang Pemerintahah Aceh. (2) Penggunakan test DNA sebagai alat bukti dalam Qanun Jinayah ditetapkan dalam Pasal 44. Pasal ini menyebutkan seorang wanita hamil sebab zina yang menyebutkan nama pasangan zinanya tidak dapat menghadirkan empat orang saksi dapat membuktikan tuduhannya dengan test DNA. Hasil test DNA tersebut bisa menjadi alat bukti untuk menggantikan empat orang saksi. (3) Menurut Hukum Islam pembuktian zina dapat dilakukan dengan dua alat bukti yaitu iqrār dan syahadah. Kedua alat bukti ini bersifat alternatif. Sementara test DNA tidak disebutkan secara pasti dalam Alquran dan hadis serta pendapat ulama. Test DNA dalam hukum Islam bisa masuk dalam jenis alat bukti pendukung dan tambahan seperti halnya kehamilan dan kelahiran anak di luar batas minimal kehamilan. Alat bukti pendukung dan tambahan seperti hasil test DNA tidak bisa menggantikan empat orang saksi.
SÍNTESE E CARACTERIZAÇÃO DE MATERIAL NANOPARTICULADO A BASE DE γ-Fe2O3 E Fe3O4
Authors: Mendes Matheus de Souza Lima , Ramos Gabriela Soares Macello , Neves Marcia Angélica Fernandes e Silva , Pedrosa Marcelo Sierpe
Published: July 2019

Nanopartículas de maghemita (γ-Fe2O3) vem sendo sintetizadas pela técnica de coprecipitação por hidrólise alcalina para magnetizar matrizes poliméricas. Neste trabalho foram sintetizadas nanopartículas de ferro caracterizadas por diferentes técnicas mostrando pelo seu tamanho de partícula que esse material apresentou propriedades superparamagnéticas.
Plano Nacional de Educação (2014-2024) sob influências do gerencialismo:
Authors: Bigarella Nadia , Costa Marilda de Oliveira
Published: July 2019

Este artigo é resultado de estudos realizado no pós-doutoramento em Educação. Tem por objetivo analisar a concepção de gestão expressa na meta 19 – gestão democrática, do Plano Nacional de Educação (2014-2024), documento organizado em 20 metas e estratégias, que expõe os problemas discutidos na área da educação brasileira. A investigação com base em fontes documentais mostrou que a referida meta apresenta um vínculo contraditório, entre gestão democrática e gerencial. A concepção de gestão democrática relacionada aos princípios constitucionais do ensino público, tem como elementos constitutivos a participação, o controle social e a cidadania. A gerencial centra-se na profissionalização da gestão, fundamentada em procedimentos administrativos usados nas empresas do mercado financeiro: eficiência, eficácia, produtividade, provocando afastamento da educação como processo histórico e prática social.
Infección por el virus de la hepatitis C en individuos transfundidos antes de 1994 en Antioquia, Colombia
Authors: Arroyave Ospina Johanna Carolina , Alvarez Flórez Claudia Marcela , Correa Arango Gonzalo , Balcázar Morales Norman , Arbeláez Montoya María Patricia , Navas Navas María Cristina
Published: July 2019

Introducción: la infección por el virus de la hepatitis C es un problema de salud pública. Según datos de la Organización Mundial de la Salud, se estiman 184 millones de casos de infección por VHC en el mundo. El principal factor de riesgo en países en desarrollo corresponde a la transfusión de componentes sanguíneos. En Colombia, en 1993, se reglamentó el tamizaje serológico en los bancos de sangre para diferentes agentes infecciosos, incluido el VHC; sin embargo, los datos de infección por VHC en la población transfundida antes de esta fecha es limitada.

Objetivo: describir la frecuencia de infección por el VHC en una población de individuos transfundidos antes de 1994 en Antioquia.

Materiales y Métodos: un total de 166 individuos transfundidos antes de 1994 aceptaron participar en el estudio. A partir de las muestras de suero se realizó la detección de anticuerpos totales contra el VHC (anti-VHC) mediante prueba de ELISA y en las muestras positivas se determinó la presencia del genoma viral por RT-PCR de la región no codificante 5’.

Resultados y conclusiones: en el población de estudio se encontró una frecuencia de anticuerpos anti-VHC de 6,6% (11/166) y presencia del genoma del VHC en 7/11 de las muestras; el genotipo 1 se identificó en 4 de las muestras. No se encontró asociación de otros factores de riesgo diferentes a transfusión en los individuos con marcadores de infección por el VHC. Este estudio aporta datos a la epidemiología de la infección por el VHC en Colombia.
Tratamiento con vitamina E en pacientes con esteatohepatitis no alcohólica Vitamin E
Authors: Vélez M. Jhonathan Ferney , Crespo H. Gustavo Amador , Restrepo Gutiérrez Juan Carlos
Published: July 2019

La esteatohepatitis no alcohólica se caracteriza histológicamente por el balonamiento de los hepatocitos, la inflamación lobulillar y la esteatosis. Al sospechar este diagnóstico es importante la exclusión de otras causas de lesión hepática principalmente el consumo excesivo de alcohol; sin embargo, la biopsia es el único método disponible hasta el momento para confirmar el diagnóstico. Para el tratamiento de esta enfermedad, la vitamina E debe ser considerada una terapia de primera línea debido a que en diversos ensayos clínicos se ha observado que aunque sin un impacto significativo en la fibrosis, a dosis de 800 UI día mejora la histología en adultos no diabéticos con NASH confirmado por biopsia. A pesar de los beneficios demostrados con el uso de este medicamento se debe tener en cuenta que no reemplaza los cambios en la dieta y el ejercicio, y que por el contrario, representa un complemento a estas medidas.
Hepatocarcinoma fibrolamelar un tumor de adultos jóvenes poco frecuente. Reporte de un caso
Authors: Toro Rendón Luis Guillermo , García Vanessa , Pérez Cadavid Juan Camilo , Hoyos Duque Sergio Iván , Chávez Trujillo Jaime Fernando , Marín Zuluaga Juan Ignacio , Santos Sánchez Oscar Mauricio , Muñoz Maya Octavio Germán , Restrepo Gutiérrez Juan Carlos
Published: July 2019

El hepatocarcinoma fibrolamelar (CHC-FL) es una rara variante del carcinoma hepatocelular (CHC), se presenta con mayor frecuencia en adultos jóvenes, sin distinción de sexo, se desarrolla en su manera más característica sobre un hígado previamente sano. La manifestación clásica está dada por la triada de masa palpable en hipocondrio derecho, dolor y pérdida de peso.

Ante la ausencia de historia de enfermedad hepática previa, es usual que se encuentre como una neoplasia avanzada de gran tamaño, la cual tiene hallazgos característicos en la tomografía o en la RM, que permiten en un alto porcentaje de casos hacer el diagnóstico solo con las imágenes.

En este tipo de neoplasias, el mejor tratamiento es la resección quirúrgica, que proporciona una sobrevida a 5 años de 58-82%, pero con unas tasas de recaídas muy elevadas, que puede variar según las series entre 33-100% de los casos.

Presentamos el caso de un paciente joven, sin historia de enfermedad hepática, en el que se diagnosticó un CHC-FL mediante el uso de resonancia magnética con medio de contraste órgano-específico y que es tratado con resección quirúrgica radical.
Bitcoin as an example of cryptocurrency – current state and perspectives
Authors: Gajdek Seweryn
Published: July 2019

The idea of anonymous digital money existing outside of traditional banking system lasts at least 40 years. It appeared as soon as technological solutions, which such a system requires, became available. The article analyses the genesis of the crypto-currencies and technological solutions implemented into the Bitcoin digital currency. The article shows current state of the Bitcoin market and changes in its price, market capitalisation and number of transactions during last decade of operations of the crypto-currency market. Although there are difficulties in using Bitcoins, which include technical background and resulting from the high volatility of prices of this currency, the continuing upward trend of the Bitcoin price and the average daily number of transactions shows that interest in this currency is growing. Bitcoin features that attract new users are a large dose of anonymity, security of funds guaranteed by the extremely high computing power of the Bitcoin network, the speed of transactions and their low cost associated with the exclusion of a financial intermediary. The features of this money and data from the market allow to expect that Bitcoin will gain more individual and institutional users.
Application of the eco-friendly subcritical water oxidation method in the degradation of epichlorohydrin
Authors: Yabalak Erdal , Topaloğlu İpek , Gizir Ahmet
Published: July 2019

Degradation of epichlorohydrin was investigated using subcritical water oxidation method in the presence of hydrogen peroxide. Degradation rate was monitored by means of total organic carbon (TOC) analysis. The central composite design was used to determine optimal TOC removal conditions and modelling experimental process. The effects of all experimental variables (temperature, oxidant concentration of hydrogen peroxide and treatment time) on the TOC removal rates were evaluated and the theoretical prediction model was proposed. Reliability of the employed model was evaluated using ANOVA. F value and the p-value of the model were found to be 84.60 and <0.0001, respectively. 93.78 % of TOC removal was achieved in the degradation of epichlorohydrin at 373 K of temperature and 75 min of treatment time using 90 mM of H2O2.
Effect of cerium oxide nanoadditive on the working characteristics of water emulsified biodiesel fueled diesel engine: An experimental study
Authors: Vellaiyan Suresh
Published: July 2019

The present article discusses the effect of cerium oxide nanoadditive inclusion on the working characteristics (combustion, performance, and emission) of water emulsified soybean biodiesel-fueled single cylinder Diesel engine. Test fuels with 5% and 10% volume of water in soybean biodiesel along with mass fraction of 100 ppm cerium oxide nanoparticle were prepared using mechanical agitator and ultrasonicator, and the experiments were conducted under different loading conditions in a single cylinder Diesel engine. The experimental results reveal that the emulsion fuel increases the peak in-cylinder pressure and net heat release values compared to pure soybean biodiesel, and cerium oxide nanoparticle inclusion reduces the peak combustion parameters value. The performance parameters such as brake specific fuel consumption and brake energy consumption are significantly improved with emulsion fuel, and the nanoparticle inclusion further improve the performance parameters. At low load conditions, the emulsion fuels increase the hydrocarbon and CO emissions, whereas these emission magnitudes are reduced at high load conditions. As far as the NOx and smoke emissions are concerned, an increase in water concentration directly reduces the emissions irrespective of load conditions. The cerium oxide nanoparticle inclusion reduces the emissions level from the water emulsified soybean biodiesel-fueled diesel engine.
Hyperbole or Reality? Investor Response to Extreme Language in Earnings Conference Calls
Authors: Bochkay Khrystyna , Hales Jeffrey , Chava Sudheer
Published: July 2019

We develop a dictionary of linguistic extremity in earnings conference calls, a setting where managers have considerable latitude in the language they use, to study the role of extreme language in corporate reporting. Controlling for tone (positive versus negative) of language, we document that when managers use more extreme words in earnings conference calls, trading volume around the call increases and stock prices react more strongly. In addition, both effects are more pronounced for firms with weaker information environments. Linguistic extremity also affects analyst opinions and contains information about a firm's future operating performance. As such, our results provide evidence that markets are influenced not just by what managers say, but also how they say it, with extreme language playing an important role in communicating reality and not merely reflecting hyperbole.
ARTIKKEL 5 Digitale mapper som evalueringsform i nettbasert utdanning
Authors: Hegerholm Hallstein
Published: July 2019

Studien undersøker bruk av digitale mapper i asynkron nettbasert utdanning. Mappevurdering er både en arbeids- og en evalueringsform som kan styrke sammenhengen mellom undervisning, læring og vurdering. Forskningsspørsmålet som reises, er: Hvordan utvikler nettstudenter kunnskap gjennom mappevurderingsprosesser? Undersøkelsen bygger på en spørreundersøkelse og en kvalitativ undersøkelse. Den legger sosiokulturell teori og andres forskning på mappevurdering til grunn. Studien viser hvordan veiledning fra lærer og studentsamarbeid styrker kunnskapsbyggingen. Den viser imidlertid også utfordringer knyttet til studentenes samarbeid.
Impacto de Facebook en la promoción de salud en Santo Domingo de los Tsáchilas - Ecuador
Authors: Acevedo Diego , Toctaguano Sandro , Troya Carlos
Published: July 2019

Objetivo. Establecer el impacto y la eficacia de la promoción de servicios de salud en un sector rural del Ecuador mediante el uso de la red social Facebook.

Método. Se utilizó la herramienta pautaje de publicidad en la red social Facebook para realizar una campaña de promoción en salud dirigida a mujeres entre 20 y 40 años en periodo de gestación. Las mujeres interesadas en participar en el estudio acudieron a la unidad de salud y llenaron una encuesta previa a la consulta con el médico ginecólogo, en la cual se indagó como obtuvieron conocimiento para acceder a la campaña. Los resultados del pautaje fueron compilados por la herramienta anuncios y promociones de la red social y los datos obtenidos de la encuesta se procesaron en hoja de cálculo Excel.

Resultados. La pauta publicitaria realizada alcanzó en 10 días a 13.504 usuarias. Del total alcanzado 463 usuarias demostraron interés en la publicación, 367 revisaron los términos y condiciones de la promoción y la información específica del estudio y su procedimiento. La campaña alcanzó al 4,36% del publico definido y la taza de efectividad de promoción de producto (clics en el enlace 367) se situó en el 2,72%. El total de mujeres que acudieron a la consulta médica fue de 41, de las cuales solo el 13,8% fueron contactadas mediante la campaña publicitaria. El 86,2% de mujeres declararon acudir por información indirecta de mujeres que vieron la campaña.

Este primer resultado muestra que la inversión económica y el presupuesto destinado alcanzó al 4,36% del publico definido y la taza de efectividad de promoción de producto (clics en el enlace 367) se situó en el 2,72%.

Conclusiones. El uso de las redes sociales como Facebook para la promoción de salud tiene  un costo mucho más bajo que utilizar los medios convencionales a través de promotores o técnicos sanitarios. El limitante encontrado, fue la poca efectividad y alcance de las redes sociales en zonas donde la oralidad como sistema de comunicación comunitaria sigue siendo preponderante.