Clinical and laboratory profile of patients with COVID-19 admitted to hospital in Moscow between May and July 2020
Authors:   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Kolobukhina L.V. , Burgasova O.A. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Kraeva L.A. ,   Pasteur Research Institute of Microbiology and Epidemiology, Saint Petersburg, Russian Federation, Gushchin V.A. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Burtseva E.I. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Kruzhkova I.S. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Khlopova I.N. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Merkulova L.N. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Krasnoslobodtsev K.G. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Kuznetsova N.A. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Shidlovskaya E.V. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Dvorkina D.A. ,   National Research Center for Epidemiology and Microbiology named after Honorary Academician N.F.Gamaleya of the Ministry of Health of the Russian Federation, Moscow, Russian Federation, Tetova V.B. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Bakalin V.V. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Odnoralov M.A. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Generalova L.V. ,   Peoples' Friendship University of Russia (RUDN University), Moscow, Russian Federation, Khayrullina A.R. ,   Pasteur Research Institute of Microbiology and Epidemiology, Saint Petersburg, Russian Federation, Antipyat N.A. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation, Shagaev A.V. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation, Ambrosi O.E. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation, Kelli E.I. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation, Ushakova E.E. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation, Smetanina S.V. ,   Clinical Hospital for Infectious Diseases No 1, Moscow Healthcare Department, Moscow, Russian Federation
Published: September 2021

Objective. Data of the clinical picture forms of the disease, management and diagnostic capabilities of patients with COVID-19 continue to be studied. Our study presents results from the analysis of clinical and laboratory parameters of patients with COVID-19 in the period May-June 2020, who were treated in an infectious diseases hospital in Moscow. Patients and methods. The analytical cohort included 444, 198 men, 246 women aged 18 to 95 years, who were identified with SARS-CoV-2 RNA. The severity of the disease was determined in accordance with the temporary clinical recommendations (version 6 effective April 28, 2020), NEWS. Results. The study of the clinical picture showed the variability of the spectrum of clinical manifestations of COVID-19. The most common symptoms were fever, weakness, myalgia, dry cough, shortness of breath, diarrhea. The severity of the infection was not associated with the patient's gender, but was significantly correlated with age and the presence of comorbid status, which included chronic lung diseases, obesity, diabetes mellitus, and cardiovascular diseases. Observations of patients with severe and extremely severe course revealed characteristic laboratory markers of severity. The main method of etiological diagnosis was the RT-PCR method for detecting SARS-CoV-2 RNA in the nasopharyngeal secret. To verify COVID-19, we used an additional PCR method, fecal testing for the detection of SARS-CoV-2 RNA. Key words: COVID-19, clinical features, risk factors, SARS-CoV-2 RNA, biological substrates