bluuebunny/crossref_metadata_2025 huggingface dataset:
Heart Failure—Do We Need New Drugs or Have Them Already? A Case of Coenzyme Q10
Authors: Filipiak Krzysztof J. , Surma Stanisław , Romańczyk Monika , Okopień Bogusław
Published: May 2022

Heart failure (HF) is a global epidemic that contributes to the deterioration of quality of life and its shortening in 1–3% of adult people in the world. Pharmacotherapy of HF should rely on highly effective drugs that improve prognosis and prolong life. Currently, the ESC guidelines from 2021 indicate that ACEI, ARNI, BB, and SGLT2 inhibitors are the first-line drugs in HF. It is also worth remembering that the use of coenzyme Q10 brought many benefits in patients with HF. Coenzyme Q10 is a very important compound that performs many functions in the human body. The most important function of coenzyme Q10 is participation in the production of energy in the mitochondria, which determines the proper functioning of all cells, tissues, and organs. The highest concentration of coenzyme Q10 is found in the tissue of the heart muscle. As the body ages, the concentration of coenzyme Q10 in the tissue of the heart muscle decreases, which makes it more susceptible to damage by free radicals. It has been shown that in patients with HF, the aggravation of disease symptoms is inversely related to the concentration of coenzyme Q10. Importantly, the concentration of coenzyme Q10 in patients with HF was an important predictor of the risk of death. Long-term coenzyme Q10 supplementation at a dose of 300 mg/day (Q-SYMBIO study) has been shown to significantly improve heart function and prognosis in patients with HF. This article summarizes the latest and most important data on CoQ10 in pathogenesis.
Carbon Fiber Reinforced Plastics in Space: Life Cycle Assessment towards Improved Sustainability of Space Vehicles
Authors: Stergiou Vasiliki , Konstantopoulos Georgios , Charitidis Costas A.
Published: May 2022

Composite materials, specifically carbon fiber reinforced plastics (CFRPs), are used in various applications such as the automotive, aerospace, and renewable energy industries, thus increasing their global production and volume consumption and creating a subsequent increase in CFRP waste. Especially in space applications and Vega launcher construction, the use of CFRP components to replace metal envisages significant benefits in the use phase by reducing weight and fuel consumption requirements. The current and future waste management and environmental legislation, considering the actual and impending EU framework on waste management, requires all engineering materials to be properly recovered and recycled from EoL products. In this study, the potential of recycling and the subsequent environmental benefits have been assessed by investigating the EoL of CFRPs through a life cycle assessment (LCA). LCA is a valuable tool for evaluating a composite material’s environmental ecological burdens over its lifetime. Therefore, it is important to the composites industry as a material selection tool when determining the applicability of recycled composites in the design phase. Particularly, the benefits from recycling methods were systematically studied in order to assess the environmental impacts of EoL scenarios, to underline the importance and necessity for the maturity increase in recycling technologies for CFRPs.
Chemical and Isotopic Composition of Sulfide Minerals from the Noho Hydrothermal Field in the Okinawa Trough
Authors: Zeng Zhigang , Chen Zuxing , Qi Haiyan , Zhu Bowen
Published: May 2022

Studies of the element contents and isotopic characteristics of sulfide minerals from seafloor hydrothermal sulfide deposits are a significant method of investigating seawater-fluid mixing and fluid-rock and/or sediment interactions in hydrothermal systems. The seafloor hydrothermal sulfide ores from the Noho hydrothermal field (NHF) in the Okinawa Trough (OT) consist of pyrrhotite, isocubanite, sphalerite, galena, and amorphous silica. The Rh, Ag, Sb, and Tl contents mostly increase in galena as the fluid temperature decreases in the late ore-forming stage. In the sulfide minerals, the rare earth elements are mainly derived from the hydrothermal fluids, while the volcanic rocks and/or sediments are the sources of the sulfur and lead in the sulfide minerals. After the precipitation of galena, the redox state becomes oxidizing, and the pH value of the fluid increases, which is accompanied by the formation of amorphous silica. Finally, neither pyrite nor marcasite has been observed in association with pyrrhotite in the NHF sulfides, likely indicating that the amount of sulfur was limited in this hydrothermal system, and most of the residual Fe was incorporated into the sphalerite. This suggests that the later pyrite and/or marcasite precipitation in the seafloor hydrothermal sulfide deposit is controlled by the sulfur content of the fluid. Furthermore, it is possible to use hydrothermal sulfides and their inclusions to trace subseafloor fluid circulation processes.
Chitosan and Nano-Chitosan for Management of Harpophora maydis: Approaches for Investigating Antifungal Activity, Pathogenicity, Maize-Resistant Lines, and Molecular Diagnosis of Plant Infection
Authors: Hassan Eman O. , Shoala Tahsin , Attia Amany M. F. , Badr Omnia A. M. , Mahmoud Sabry Y. M. , Farrag Eman S. H. , EL-Fiki Ibrahim A. I.
Published: May 2022

The rapid spread of late wilt disease among maize cultivations has resulted in serious economic losses in many countries. Harpophora maydis is the main cause of this destructive vascular disease. Here we evaluate the fungicidal activity of chitosan and nano-chitosan against six aggressive isolates of H. maydis collected from different Egyptian governorates. Pathogenicity tests for these isolates show that the highest disease severity was found for the Giza isolate. The isolates were tested for their response to the fungicide Permis, chitosan, and nano-chitosan treatments in vitro and in vivo. Nano-chitosan treatments fully inhibited the radial growth of H. maydis isolates at concentrations of 5 and 10 mM, compared to the full control growth (9 cm in diameter). On the other hand, in vitro, in vivo, and molecular diagnosis results showed high antifungal activity of chitosan and nano-chitosan compared to the Permis fungicide. Chitosan at the nano and normal scales proved a potent ability to enhance plant resistance in response to H. maydis. Disease severity (DS%) was extremely decreased among the tested cultivars by using nano-chitosan; the highest percentage was obtained on Giza 178 cv, where the DS% was 21.7% compared to 42.3% for the control. Meanwhile, the lowest percentage was obtained on Giza 180 cv with DS% 31.2 and the control with 41.3%. The plants treated with nano-chitosan showed the highest growth parameters for all cultivars. Such natural treatments could reduce the impact on the environment as they are non-pollutant natural compounds, protect the plants by reducing fungal activity, and induce plant resistance.
Gram-Level Production of Balanol through Regulatory Pathway and Medium Optimization in Herb Fungus Tolypocladium ophioglossoides
Authors: Li Rui-Qi , Liu Xiang , Zhang Min , Xu Wei-Qun , Li Yong-Quan , Chen Xin-Ai
Published: May 2022

As a potential protein kinase C inhibitor, the fungus metabolite balanol has become more attractive in recent decades. In our previous work, we revealed its biosynthetic pathway through overexpression of the cluster-situated regulator gene blnR in Chinese herb fungus Tolypocladium ophioglossoides. However, information on the regulation of blnR is still largely unknown. In this study, we further investigated the regulation of balanol biosynthesis by BlnR through the analysis of affinity binding using EMSA and RNA-seq analysis. The results showed that BlnR positively regulates balanol biosynthesis through binding to all promoters of bln gene members, including its own promoter. Microscopic observation revealed blnR overexpression also affected spore development and hypha growth. Furthermore, RNA-seq analysis suggested that BlnR can regulate other genes outside of the balanol biosynthetic gene cluster, including those involved in conidiospore development. Finally, balanol production was further improved to 2187.39 mg/L using the optimized medium through statistical optimization based on response surface methodology.
Vertically Transmitted Epichloë Systemic Endophyte Enhances Drought Tolerance of Achnatherum inebrians Host Plants through Promoting Photosynthesis and Biomass Accumulation
Authors: Zhong Rui , Bastías Daniel A. , Zhang Xingxu , Li Chunjie , Nan Zhibiao
Published: May 2022

Achnatherum inebrians (drunken horse grass, DHG) plants, a dominant grass species in the arid and semi-arid regions of northwest China, symbiotic with an Epichloë fungal endophyte, is well adapted to drought. However, little is known about how the presence of the foliar Epichloë endophyte enhances the tolerance of DHG to drought at the molecular level. This study explored the positive effects of the presence of the Epichloë endophyte on plant growth, biomass, and photosynthetic efficiency and processes of DHG under non-drought and two drought (moderate and severe) treatments, using RNA sequencing to compare transcriptomes. The transcriptome results showed that 32 selected unigenes involved in the photosynthesis processes within Epichloë symbiotic plants were differently expressed (DEGs) versus non-symbiotic plants. The majority of these selected DEGs were upregulated in Epichloë symbiotic plants versus non-symbiotic plants, such as upregulated unigenes (c51525.graph_c1, c47798.graph_c0 & c64087.graph_c0) under drought conditions. In line with the transcriptomes data, the presence of the Epichloë endophyte promoted the photosynthetic rate and biomass accumulation of DHG plants, and the relationship between the photosynthetic rate and biomass is linear and significant. The presence of the endophyte only increased the biomass per tiller of DHG plants under drought. This study provides further insights into the molecular mechanisms that underlie the enhanced plant growth and drought tolerance of Epichloë-symbiotic DHG plants.
Dynamics between Power Consumption and Economic Growth at Aggregated and Disaggregated (Sectoral) Level Using the Frequency Domain Causality
Authors: Dash Ashutosh , Jena Sangram Keshari , Tiwari Aviral Kumar , Hammoudeh Shawkat
Published: May 2022

We investigated the Granger causal relationship between the consumption of power both at the aggregate and sectoral level and economic growth in India using the frequency domain approach, which would help policy makers seek the efficient allocation of electricity via proper policy initiatives at different frequencies. We find that at the aggregate level, unidirectional causality runs from the total power consumption to economic growth, starting from the second up to the seventh quarter. In the sectoral context, the results are different. Since there is no causality between industrial power consumption and economic growth; therefore, an energy conservation policy can thus be implemented for the industrial sector. Moreover, since a bidirectional causality exists after 15 quarters for the commercial sector, a short-term policy but not an energy conservation policy could also be initiated for this sector. In the industrial and agricultural sectors, a promotional policy should be initiated because a unidirectional causality exists from sectoral power consumption to economic growth. Therefore, different and sector-specific policies would be more appropriate than a single policy for all power sectors in India in order to orient the efficient utilisation of power towards better economic development.
A Practicable Operationalisation of Meaningful Human Control
Authors: Kwik Jonathan
Published: May 2022

Meaningful Human Control (MHC) has been a consistent key term in legal debates concerning autonomous weapon systems (AWS), but its usefulness as a policy or lawmaking tool is limited due to a lack of clarity on what the concept encompasses. This study engaged in a thorough literature study of official statements, policy papers and academic papers published between 2013–2021 to determine features common to these proposals and synthesise a workable framework of MHC. The framework identifies five core elements—awareness, weaponeering, context control, prediction and accountability—and many interlocking mechanisms which link these elements together in a causal and chronological manner corresponding to the military targeting process. Subsequently, a detailed commentary and discussion is provided on the individual differences between sources, how specific elements can be implemented in practice by military commanders, and particularly controversial points are highlighted which require specific consideration by commentators and policymakers. The framework identifies concrete and practicable ways commanders can exercise control over AWS and serves as a solid foundation for further legal analysis of commanders’ duties when employing AWS, for future policy discussions, and as a problem-solving tool to resolve important legal questions such as the ubiquitous ‘accountability gap’ conundrum.
Probing Adamantane Arylhydroxamic Acids against Trypanosoma brucei and Trypanosoma cruzi
Authors: Foscolos Angeliki Sofia , Tsotinis Andrew , Taylor Martin C. , Kelly John M. , Papanastasiou Ioannis P.
Published: May 2022

In this work, we present the synthesis and the anti-trypanosomal activity of the 2-(4-(adamant-1-yl)phenyl)-N-hydroxyarylamides, 1a,b and the 2-(4-(adamant-1-yl)phenoxy)-N-hydroxyacetamide, 1c. The 4-(adamant-1-yl)phenyl- and 4-(adamant-1-yl)phenoxy- moieties, which are endowed with promising drug-like properties, are functionalized at the side chain termini as hydroxamic acids. The phenoxy acetohydroxamic derivative, 1c, shows the most interesting profile in terms of activity and toxicity against trypanosomes and merits further investigation.
Banach Limit and Ulam Stability of Nonhomogeneous Cauchy Equation
Authors: El-hady El-sayed , Brzdęk Janusz
Published: May 2022

We prove new results on Ulam stability of the nonhomogeneous Cauchy functional equation f(x+y)=f(x)+f(y)+d(x,y) in the class of mappings f from a square symmetric groupoid (H,+) into the set of reals R. The mapping d:H2→R is assumed to be given and satisfy some weak natural assumption. The equation arises naturally, e.g., in the theory of information in a description of generating functions of branching measures of information. Moreover, we provide a suitable example of application of our results in this area at the very end of this paper. The main tool used in the proofs is the Banach limit.
Simple mucopexy and hemorrhoidal arterial ligation with and without Doppler guide: a randomized clinical trial for short-term outcome
Authors: Alemrajabi Mahdi , Akbari Abolfazl , Sohrabi Sara , Rezazadehkermani Mohammad , Moradi Mohammad , Agah Shahram , Masoodi Mohsen
Published: May 2022

Purpose: Hemorrhoids are the most common benign anorectal diseases. Mucopexy strengthens the anal canal mucosa, which can be performed alone or in combination with Doppler-guided hemorrhoidal artery ligation (DG-HAL). In this study, we compared the postoperative complications between simple mucopexy plus HAL with and without a Doppler guide.Methods: This study was performed as a single-blinded randomized clinical trial. Patients referred to a tertiary colorectal referral clinic with grades 3 and 4 hemorrhoids who were candidates for surgical intervention entered the study. Thirty-six patients were randomly divided into 2 groups. Group A including 18 patients underwent mucopexy and DG-HAL and the other 18 patients (group B) underwent standard mucopexy and HAL without a Doppler guide. Postoperative pain score and the duration of oral analgesic consumption were recorded. Additionally, postoperative symptoms and complications were recorded and compared between the 2 methods.Results: There was no significant difference between the 2 groups in terms of pain score and the duration of postoperative analgesic consumption as well as the incidence of postoperative complications. Besides, the primary grade of hemorrhoids was not significantly associated with recurrence, but there was a significant association between body mass index and Wexner score (WS) with recurrence. The mean WS of patients showed a significant decrease in both groups postoperatively. However, the rate of WS reduction was not remarkably different between the 2 groups.Conclusion: Simple mucopexy with blind HAL (without Doppler guide) might be considered for the treatment of grades 3 and 4 hemorrhoids effectively.
PID algoritmus algoritmizálása irányítórendszerekben
Authors: Móré Ádám , Trohák Attila
Published: May 2022

A cikk egy alkalmazott analóg PID algoritmus elkészítését mutatja be. Az algoritmus FBD (Funkció Blokk Diagramm) IEC szabványosított nyelven valósul meg. Az FBD programozási nyelvet PLC (Programmable Logic Control) és DCS (Distributed Control system) fejlesztői környezetek is támogatják. A cikk bemutatja, hogy egy matematikai numerikus analóg képletből, hogyan lehet készíteni egy algoritmust, melyet az irányítórendszerben tudunk használni. Különböző alkalmazásokon keresztül foglalkozik a felhasználó által készített algoritmus előnyével.
Penerapan Adab Bersosial Media Daptoon Pada Siswa Kelas IV SD
Authors: Yusriutami Amelia , Maryam Siti , Nurmala Ai , Aeni Ani Nur
Published: May 2022

Adab bersosial media adalah suatu aturan yang baik tentang bersosial media dimana pada zaman sekarang teknologi semakin maju dan tentunya perkembangan segala hal dalam sosial media juga terjadi, dengan adanya adab bersosial media ini kita dapat mencegah suatu hal yang buruk terjadi pada kita, dalam bersosial media khususnya pada siswa sekolah dasar dimana masih membutuhkan bimbingan dalam segala hal. Media sosial juga tidak bisa dihindari di zaman modern seperti saat ini termasuk dalam pembelajaran juga dilaksanakan dari beberapa media sosial. Lewat sosial media, para pelajar secara aktif bisa lebih kreatif dan mandiri sehingga kualitas pelajaran bisa semakin meningkat baik dari segi pengetahuan maupun kualitas. Beberapa media yang sudah banyak digunakan bisa menjadi salah satu pemicu kualitas siswa. Bila pemanfaatannya dilakukan secara maksimal, bukan tidak mungkin hal tersebut bisa lebih meningkatkan kualitas dari ilmu tertentu namun tentunya harus diikuti dengan minimalisir dampak negatifnya. Tujuan dari penelitian ini untuk mengetahui design yang menarik bagi siswa pada sebuah video animasi atau disebut dengan “Daptoon” tentang Penerapan Abad Bersosial Media Melalui “Daptoon” Pada Kelas IV SD. Selain itu bertujuan untuk mengedukasi dan memotivasi siswa agar lebih mengetahui tentang adab dalam bersosial media. Penelitian ini menggunakan model Design and Development (D&D). Hasil dari angket yang disebar menyatakan bahwa media “Daptoon” ini dapat dipahami dan lebih nudah dimengerti oleh siswa.
Pengaruh Kompetensi Pegawai Dan Fasilitas Kerja Terhadap Kualitas Pelayanan Publik Di Kantor Desa Purworejo
Authors: Inzaghi Adelia Ovi , Rosy Brillian
Published: May 2022

Reformasi birokrasi Indonesia yang ditetapkan pada tahun 2010, seiring berjalannya waktu terus mengalami evaluasi untuk mengatasi beberapa masalah, salah satunya dalam peningkatan kualitas pelayanan publik. Berdasarkan observasi yang dilakukan di lapangan masih adanya  masyarakat yang termarginalisasikan (pengabaian atas hak-hak yang seharusnya didapat oleh masyarakat) baik dari pelayanan administrasi, hingga pelayanan yang lainnya. Sehingga dalam penelitian ini bisa dilaksanakan dengan tujuan untuk mengetahui pengaruh variabel  kompetensi pegawai dan fasilitas kerja secara simultan maupun parsial terhadap  kualitas pelayanan publik . Metode penelitian yang digunakan adalah kuantitatif, hal ini ditunjukkan oleh penggunaan teknik pengambilan sampel purposive sampling pada jumlah sampel sebanyak 31 responden. Dimana teknik ini mengambil metode kuesioner dengan menggunakan jenis pertanyaan tertutup. Analisis yang dihasilkan dari data yang digunakan adalah regresi linier berganda. Dengan memiliki hasil pada uji hipotesis bahwa kompetensi pegawai pada kualitas layanan publik ditunjukkan dengan   lebih besar dari nilai   (7.058 > 2.048) , sedangkan variabel fasilitas kerja terhadap kualitas pelayanan publik  menunjukkan hasil   lebih kecil dari nilai   (0,139 < 2.048), serta uji F memperoleh hasil   mendominasi  nilai   sebesar (43,922 > 3,34). Dari hasil tersebut maka dapat ditarik kesimpulan pada kompetensi pegawai menunjukkan bahwa terdapat pengaruh secara parsial terhadap kualitas pelayanan publik dan fasilitas kerja secara parsial tidak berpengaruh terhadap kualitas pelayanan publik serta secara simultan pada kompetensi pegawai dan fasilitas kerja berpengaruh terhadap kualitas pelayanan publik. Berdasarkan kesimpulan hasil penelitian, disarankan kantor desa mengadakan peningkatan bimbingan teknis, pelatihan manajerial kepada pegawai desa serta meningkatkan fasilitas kerja yang memadai dengan pengadaan teknologi guna meningkatkan kualitas pelayanan publik kepada masyarakat.
انخفاض التحصيل الدراسي لطلبة الصف السادس الأدبي في مدارس محافظة بابل في الامتحانات العامة من وجهة نظر المدرسين
Authors: D.r. Suhad Kamil Jabar Al-Fatlawy
Published: May 2022

يهدف البحث الحالي إلى التعرف على أسباب انخفاض التحصيل الدراسي لطلبة الصف السادس الأدبي في مدارس محافظة بابل  في الامتحانات العامة من وجهة نظر المدرسين.     لتحقيق هدف البحث اعدت الباحثة استبانة مكونة من (62) فقرة  للتعرف على أسباب انخفاض التحصيل, يمثل كل منها سبباً من الأسباب المحتملة لتدني التحصيل تم التحقق من صدقها وثباتها، استخدمت الباحثة المنهج الوصفي في البحث، تألفت عينة الدراسة من (310) مدرساً ومدرسة اي نسبة ما يقارب (10%) من المجتمع الكلي, توزعوا على المدارس الاعدادية  الحكومية في محافظة بابل  للعام الدراسي2019– 2020م، وبعد تحليل البيانات اللازمة من خلال برنامج(SPSS) أظهرت الدراسة النتائج الآتية :    أظهرت تقديرات المدرسين إن أكثر الأسباب أهمية لانخفاض التحصيل الدراسي، كان في مقدمتها عدم وجود الرغبة الذاتية في الدراسة لدى الطالب, الظروف الاقتصادية والأمنية والسياسية الصعبة كذلك الاهتمام بوسائل اللهو والترفيه والانترنت في المنزل, اضافة الى قلة استخدام أساليب حديثة وطرائق جذابة في التدريس، فضلاً ضعف التواصل بين المدرسة والبيت، وغيرها من الاسباب الاخرى الوارد في أداة البحث.    في ضوء النتائج التي توصل إليها البحث الحالي قدمت مجموعة من الاستنتاجات والتوصيات والمقترحات كإجراء دراسات أخرى مماثلة للدراسة الحالية على الطلاب في مراحل دراسية أخرى
استخدام مدرسي الفيزياء للتدريس الواقعي وعلاقته بتوجهاتهم المعرفية
Authors: Dr. Muslim Mohammed Jasim AlNabhan
Published: May 2022

هدف البحث الى التعرف على استخدام مدرسي الفيزياء للتدريس الواقعي والتوجهات المعرفية لمدرسي الفيزياء والعلاقة الارتباطية بينهما ، وتكون مجتمع البحث من جميع مدرسي الفيزياء في محافظة الديوانية البالغ عددهم 184 مدرسا وقد مثلوا بعددهم هذا عينة البحث ، اعد الباحث اداتين الاولى للتعرف على استخدام المدرسين للتدريس الواقعي مكونة من ثلاثة مجالات ( تحليل محتوى التعلم ، التخطيط ، تنفيذ التدريس ) لكل مجال منها 11 فقرة ، اما الاداة الثانية كانت مقياس التوجهات المعرفية المكون من  أَربعة أَبعاد هي( التوجه الى ان المعرفة ثابتة ، الاعتقاد في المعرفة بسيطة، الاعتقاد في التعلم السريع ،الاعتقاد في المعرفة المؤكدة ) وتكون المقياس من  (42) فقرة  وأَمام كل فقرة خمسة بدائل هي: (موافق ، غالبا، احيانا، نادرا ، غير موافق) ، واستخدم الباحث عددا من الوسائل الاحصائية لمعالجة النتائج التي اكدت استخدام المدرسين للتدريس الواقعي وتوجهاتهم الايجابية نحو المعرفة ووجود علاقة ارتباطية قوية موجبة بين استخدام مدرسي الفيزياء للتدريس الواقعي وتوجهاتهم المعرفية ، وفي ضوء نتائج البحث استنتج الباحث عددا من الاستنتاجات ووضع عددا من التوصيات والمقترحات.
اثر أنموذج مقترح على وفق نظرية "Paivio" في تحصيل مادة التاريخ والتفكير العقلاني لدى طلاب الصف الخامس الادبي
Authors: M.D. Firas Trad Ali Al-Jubouri,
Published: May 2022

يرمى هذا البحث إلى التعرف على (اثر أنموذج مقترح على وفق  نظرية  "Paivio"  في تحصيل مادة التاريخ والتفكير العقلاني لدى طلاب الصف الخامس الادبي) ،ويمكن تفصيل هدفا البحث الى ما ياتي:

1-  بناء أنموذج تدريسي على وفق نظرية  "Paivio"  .

2- التثبت من فاعلية الأنموذج المقترح في تحصيل مادة التاريخ والتفكير العقلاني لدى طلاب الصف الخامس الادبي. لتحقيق هدف البحث تم بناء أنموذج تدريسي على وفق نظرية  "Paivio"   باستعمال منهج البحث الوصفي. و للتحقق من اثره صيغت الفرضيتان الصفريتان الاتيتان: 1: لا يوجد فرق ذو دلالة إحصائية عند مستوى دلالة (0.05) بين متوسط درجات طلاب المجموعة التجريبية الذين يدرسون وفق الانموذج المقترح ومتوسط درجات طلاب المجموعة الضابطة الذين يدرسون بالطريقة الاعتيادية في اختبار التحصيل الدراسي البعدي .

2: لا يوجد فرق ذو دلالة إحصائية عند مستوى دلالة (0.05) بين متوسط درجات طلاب المجموعة التجريبية الذين يدرسون وفق الانموذج المقترح ومتوسط درجات طلاب المجموعة الضابطة الذين يدرسون بالطريقة الاعتيادية في مقياس التفكير العقلاني ،وتحدد البحث بعينة من طلاب الصف الخامس الأدبي من اعدادية ابن النفيس في محافظة القادسية للعام الدراسي( 2020 – 2021 ) م . واختار الباحث التصميم التجريبي ذا الضبط الجزئي ، وتم اختيار شعبتين من الصف الخامس الادبي عشوائياً، وبلغت عينة البحث (59) طالب بواقع (30) طالب في المجموعة التجريبية وتمثل الشعبة (ج) الذين درسوا بالأنموذج المقترح، والمجموعة الضابطة (29) طالب وتمثل شعبة (أ) الذين درسوا بالطريقة الاعتيادية وأجري بينهما تكافؤ في المتغيرات (العمر الزمني، المعلومات السابقة ، الذكاء، مقياس التفكير العقلاني، التحصيل الدراسي للأبوين) ،وأعد الباحث اختبارا للتحصيل النهائي، وتأكد من صدقه وثباته ومعامل صعوبته والقوة التمييزية لفقراته وفعالية البدائل الخاطئة ، كما اعد الباحث مقياسا للتفكير العقلاني وتأكد من صدقة وثباته ومعامل صعوبته والقوة التمييزية ، وفي نهاية التجربة طبق الباحث ادوات بحثه وعالج بياناته إحصائياً باستعمال (spss20) واظهرت النتائج تفوق طلاب المجموعة التجريبية التي درسوا بالانموذج المقترح على المجموعة الضابطة الذين درسوا بالطريقة الاعتيادية في التحصيل .ومقياس التفكير العقلاني وفي ضوء نتائج البحث أوصى الباحث بضرورة استعمال الانموذج المقترح في التحصيل والتفكير العقلاني كما قدم الباحث مجموعة من التوصيات والمقترحات ، أبرزها إجراء دراسات مماثلة للدراسة الحالية على مراحل دراسية أخرى لكلا الجنسيين. كذلك التعرف على فاعلية الانموذج المقترح على متغيرات تابعة أخرى مثل التفكير الإبداعي ، والثقة بالنفس ، والاتجاه نحو المادة ، وغيرها .
مهارات التفكير الناقد المتضمنة في كتاب قواعد اللغة العربية للصف السادس الإعدادي ومدى اكتساب الطلبة لها
Authors: M. Saad Jadallah Hamad Al-Jubouri
Published: May 2022

هدفت هذه الدراسة إلى تحديد مهارات التفكير الناقد الواجب توافرها في كتاب قواعد اللغة العربية للصف السادس الإعدادي إلى معرفة مدى توافر هذه المهارات في محتوى كتاب قواعد اللغة العربية، ومدى اكتساب الطلبة لها. وقد تضمنت الدراسة السؤال الآتي:

ما مهارات التفكير الناقد الواجب توافرها في كتاب قواعد اللغة العربية، و مدى اكتساب الطلبة لها؟.

محتوى كتاب قواعد اللغة العربية الذي أقرته وزارة التربية للعام 2021- 2020 م. وهو عبارة عن كتاب يدرس لطلبة الصف السادس الإعدادي في العراق.

وتكونت عينة الدراسة على (100) طالباً من طلاب الصف السادس الإعدادي بمحافظة كركوك.

وقد أستخدم الباحث المنهج الوصفي التحليلي، بهدف جمع المعلومات وتفسيرها حول كتاب قواعد اللغة العربية. واستخدم في هذا البحث عدة أدوات هي: إعداد قائمة لمهارات التفكير الناقد من أجل استخدام تلك القائمة في تحليل كتاب قواعد اللغة العربية، كما استخدم أداة تحليل المحتوى، والتي اعدت في تحليل كتاب قواعد اللغة العربية للصف السادس الإعدادي، في ضوء مهارات التفكير الناقد.

كما قام الباحث باستخدام اختبار لقياس مدى اكتساب الطلبة لمهارات التفكير الناقد الموجودة في الكتاب، حيث تضن ثلث مهارات هي: مهارة تقويم المناقشة، ومهارة التفسير، ومهارة الاستنباط.

 بالنسبة لأداة تحليل المحتوى: استخدم الباحث حساب صدق التحليل عن طريق تحليل فصل من فصول كتاب قواعد اللغة العربية للصف السادس الإعدادي، تم اختيار الفصل عشوائياً، وتبين من التحليل شمول قائمة ومهارات التفكير الناقد، كما قام الباحث بعرض استبيان على المحكمين من الخبراء والمتخصصين في مجال المناهج. واستخدم الباحث التكرارات، والنسب المئوية ومعامل الارتباط كأساليب إحصائية لمعالجة بيانات البحث. بالنسبة لأداة اختبار التفكير الناقد: فقد استخدم الباحث النسب المئوية والمتوسط الحسابي والمتوسط النسبي وتم إيجاد معامل الثبات باستخدام طريقة التجزئة النصفية والفا   كرونباخ وهي طريقة أخرى لمعرفة فقرات الاختبار. ونتائج البحث توصلت فيما يتعلق بتحليل المحتوى في ضوء مهارات التفكير الناقد: فقد حصلت مهارة تقويم المناقشة على نسبة ( %45 )، في حين حصلت مهارة التفسير على نسبة ( %37 )، أما مهارة الاستنباط فقد حصلت على نسبة ( %18). أما اختبار التفكير الناقد: فقد دلت النتائج على أداة أفراد العينة لاختبار مهارات التفكير الناقد في الصف السادس الإعدادي يقع في المستوى المتوسط، حيث كانت نسبة الأداء ( % 60)، وتبين أن مستوى مهارة تقويم المناقشة كانت أعلى نسبة (%65)، بينما كان مستوى مهارة التفسير في المرتبة الثانية بنسبة (%57)، وفي مسوى ضعيف كان الاستنباط بنسبة (%32). كما تبين أنه توجد فروق ذات دلالة إحصائية في مستوى مهارات التفكير الناقد في كتاب قواعد اللغة العربية لدى طلبة الصف السادس الإعدادي.
بناء أنموذج لتقويم منهج التاريخ للمرحلة الاعدادية من وجهة نظر مدرسي المادة
Authors: A.M.D. Hoda Fadel Hussein
Published: May 2022

هدف  البحث الى بناء أنموذج لتقويم منهج التاريخ للمرحلة الاعدادية في جمهورية العراق ، ومن ثم أستخدام الانموذج في تقويم منهج التاريخ من وجهة نظر مدرسي ومدرسات مادة التاريخ. اعتمد المنهج الوصفي لتحقيق هدف البحث،و شملت عينة البحث (140) مدرسا ومدرسة لمادة التاريخ في المدارس الاعدادية التابعة لمديريات تربية الرصافة. اعدت أداة البحث( الاستبانة ) مشتملة على ستة  مجالات، وضمت في صيغتها النهائية (96) فقرة ، وتم التحقق من صدق الاداة وثباتها.استخدمت الحقيبة الاحصائية لحساب الوسط المرجح والوزن المئوي كوسائل أحصائية للتعرف على نتائج البحث ،والتي أظهرت تحقق جميع مجالات أنموذج تقويم المنهج وبالترتيب  من الاعلى للادنى وعلى التوالي : الاهداف التعليمية، المحتوى التعليمي، أساليب القياس والتقويم،طرائق التدريس،النشاطات التعليمية،التقنيات التربوية.وخلص البحث الى عدد من الاستنتاجات والتوصيات والمقترحات.
فاعلية انموذج بيركنز وبلايث في التحصيل وتنمية التفكير الناقد لدى طلاب الصف الخامس الادبي في مادة التاريخ
Authors: Raad Talib Kazem
Published: May 2022

هدف البحث الحالي معرفة فاعلية انموذج بيركنز وبلايث في التحصيل وتنمية التفكير الناقد لدى طلاب الصف الخامس الادبي في مادة التاريخ ، واستخدم الباحث تصميما تجريبيا ذا ضبط جزئي يحوي مجموعتين تجريبية وضابطة واختيرت العينة عشوائياً والتي تمثلت بـ ( إعدادية الديوانية للبنين) التابعة لمديرية تربية القادسية ،كافأ الباحث مجموعتي البحث في: العمر الزمني ، تحصيل الوالدين ،التحصيل السابق ،واختبار التفكير الناقد ،وحدد المادة العلمية وصاغ الأهداف السلوكية للمادة التعليمية اذ بلغ عددها (165)هدفا سلوكياً، وعَمَدَ الباحث إلى بناء أدوات البحث وهي اختبار التحصيل المكون من (40) فقرة من نوع الاختيار من متعدد ذي أربعة بدائل إما الأداة الثانية فقد تمثلت باختبار التفكير الناقد والذي تكون بصيغته النهائية من (30) فقرة على وفق المهارات التي حددها كل من واطسون وكلاسر للتفكير الناقد. وأظهرت النتائج تفوق طلاب المجموعة التجريبية الذين درسوا على وفق انموذج بيركنز وبلايث على طلاب المجموعة الضابطة الذين درسوا على وفق الطريقة الاعتيادية في اختباري التحصيل والتفكير الناقد
ADULT STEM CELL RELEASED MOLECULES IN COMBINATION WITH MICRONEEDLING RESTORE HAIR GROWTH
Authors: Ryan Michael , Maguire Greg
Published: May 2022

Introduction: Alopecia is a chronic dermatological disorder affecting millions of people, in which people lose some or all of the hair on their head.
Although alopecia has many forms, all are characterized as a chronic inammatory disease that affects the hair follicles. Alopecia often has
psychological consequences, including high levels of anxiety and depression.
Case presentation: We report hair regrowth in 12 patients with alopecia treated with adult stem cell released molecules in combination with micro
needling.
Conclusion: Adult stem cell released molecules in combination with micro needling is an efcacious, safe, and affordable treatment for alopecia.
AN OPTIMAL REPLACEMENT PROBLEM FOR A SHOCK MODEL WITH DIFFERENT MODES OF FAILURES USING ALPHA SERIES PROCESSES
Authors: Ramudu B.Venkata
Published: May 2022

This paper studies a shock model for a repairable system with two-type failures by assuming that two kinds of shocks in a sequence of random
shocks will make the system failed, one based on the inter-arrival time between two consecutive shocks less than a given positive value and the
other based on the shock magnitude of single shock more than a given positive value . Further it is assumed that the system after repair is not ‘as
good as new’, but the consecutive repair times of the system form a stochastic increasing α-seires process. Under these assumptions, we determine
an explicit expression for the average cost rate and an optimal placement policy N* based on the number of failure of the system is determined such
that the long-run average cost per unit time is minimized. The explicit expression of long-run average cost per unit time is derived, and the
corresponding optimal replacement policy can be determined analytically or numerically. Finally, a numerical example is given.
SODIUM BICARBONATE DEFEATS CORONAVIRUS
Authors: Basta Tayeb
Published: May 2022

Scientists emphasize that the human body must maintain a pH level between 7.35-7.45 to survive and function properly. Acidosis in the blood is
characterized by a drop in pH to less than 7.35. Scientists also claim that the presence of acidosis in the blood facilitates virus entry into host cells,
where it then thrives and replicates.
According to chemistry, when diluted in an acidosis aqueous liquid, sodium bicarbonate absorbs the H+ ions and produces water and carbon
dioxide gas.As a result, it restores the liquid state to equilibrium.
Based on these ndings, we propose a new strategy for combating coronavirus. Rather than using drugs or vaccination to combat the virus, this
strategy involves depleting the virus's resources. We use sodium bicarbonate to achieve this by bringing the pH of the blood back to normal.
Athletes use sodium bicarbonate to improve their performance in a variety of exercises, conrming the safety of sodium bicarbonate on human
bodies.
One important difference between sodium bicarbonate and drugs and vaccination is that sodium bicarbonate is given to covid-19 patients to cure
them as well as non-patients to bring their pH level to equilibrium and thus neutralize the effects of viruses.
The current work is a solid scientic discovery; we recommend putting it through a clinical trial to determine the dosage of sodium bicarbonate
required to cure each case. Its success could propel us to the forefront of the ght against SARS-CoV-2 and other viruses.
A STUDY OF HYPONATREMIA IN CRITICALLY ILL CHILDREN IN PAEDIATRIC INTENSIVE CARE UNIT
Authors: Agrawal Ankit , Agarwal Khushboo , Agarwal Anil
Published: May 2022

Background: Hyponatremia is the most common electrolyte disturbance in critically ill children. Although hyponatremia in hospitalized children
is associated with adverse outcomes, the risk can be reduced by early diagnosis and intervention. This study was done to determine theObjective:
frequency of hyponatremia among children admitted in pediatric intensive care unit (PICU). Demographic data, detailed history,Methods:
systemic examinations, and routine blood and urine investigations were conducted if required for 700 critically ill children aged 1 month to more
than 10 years admitted in the PICU. Serum sodium level was classied into the three grades of severity: Mild (130–134 mEq/L), moderate
(125–129 mEq/L), and severe (<125 mEq/L). The overall prevalence of hyponatremia was 35.1%. Hyponatremia (130.21) patients haveResults:
signicant lower sodium value than Normonatremia (138.92) and Hypernatremia (150.48). Mortality was signicantly lower among the
hyponatremic children (3.7%) as compared to hypernatremia (9.1%) and normonatremia (4.6%) Hyponatremia during admissionConclusion:
increased the risk of mortality by 3.7 times. Low serum sodium levels at admission also predicted an increased dependency on ionotropic support
and mechanical ventilation with dismal patient outcome in terms of survival.
A PILOT STUDY ON THE EFFECT OF PRAMIPEXOLE IN CALLUS FORMATION IN DISTAL RADIUS FRACTURES IN PERIMENOPAUSAL FEMALES
Authors: Charkraborty Aviroop , Jana Arijeet , Chatterjee Biplab , Kumar Divyanshu
Published: May 2022

This is a pilot study that was conducted over a period of three months in Burdwan Medical College and Hospital, on the effect of Pramipexole on
distal radius fracture callus formation in perimenopausal females (40 – 60 years). There were a total of 11 patients studied during a period of 3
months. Cases were followed for 4 complete weeks following discharge after applying proper manipulation and reduction of fracture and
subsequent application of plaster cast. Ultrasonography of the distal end of affected radius was utilized to estimate volume of callus formation. Two
treatment arms (one with pramipexole and one with symptomatic treatment) were created and their efcacy with regard to callus formation was
observed. Following cleaning of data, mean case volume was found to be two whole orders of magnitudes greater than mean control volume.
Welch’s T-test was subsequently carried out and showed a near statistically signicant large effect size of 1.21 (p=0.055, t=2.046, right tailed). This
effect size is quite large and may be taken to indicate signicant clinical relevance of using pramipexole. Further studies are recommended to
follow up on these results, with increased sample size, and multiple measurements of callus volume to observe the dose-callus-time relationship. In
conclusion, this drug seems a promising cost-effective way to augment and speed up callus formation with good clinical outcome.
MUCORMYCOSIS- A CHALLENGE TO DIAGNOSE
Authors: Ghosh Mainak , Basu Subhransu , Saraf Ankita , Saha Ruma , Chakraborty Mouli , Roy Subhadip
Published: May 2022

Mucormycosis, an angioinvasive fungal infection of the order Mucorales became very common due to COVID-19
pandemic situation in maxillofacial clinic still remained much undiagnosed disease due to patient’s other complaints
and lack of history given.We shall be discussing about such case in this paper.
THE EFFECTIVENESS OF THE TWO-LAYERED CLOSURE OF PERSISTENT OROANTRAL FISTULA USING BUCCAL FAT PAD AND BUCCAL ADVANCEMENT FLAP.
Authors: Jyotsna Jyotsna , kumar Jha Sanjeev
Published: May 2022

Background: A prospective clinical study was conducted to assess the effectiveness of the two -layered closure of
recurrent Oroantral Fistula using Buccal Fat Pad and Buccal Advancement Flap.
Materials and methods: Twenty patients with persistent OAFs larger than 5 mm were treated with two layered closure
using Buccal Fat Pad and Buccal Advancement Flap.They were followed clinically and radiographically for 5 years after
surgery to monitor the durability and effectiveness of the two layered closure of the OAF.
Result: The procedure was successful in all patients. The healing process was satisfactory,with no breakdown or
liquefaction necrosis postoperatively.No complications were observed during the follow-up period.
Conclusion: The results of this study support the view that the use of the double-layered closure using BFP with buccal
advancement flap is a durable,convenient,and effective method for the treatment of a persistent large OAF.
INCULCATING VALUES IN SCHOOL STUDENTS: A RECOMMENDED PROGRAMME
Authors: Chaturvedi Amit
Published: May 2022

School Education Systems are charged with the daunting task of preparing the next generation of citizens. However, the
research shows that School Education Systems, both government aided and government unaided, have struggled to
effectively inculcate human and social values to meet the needs of our fast-changing Environment and Society. The
affective development of a child is focused very less compared to cognitive development. Moral science as a subject is
not focused as much as it deserves. Inculcating human and social values in students aims at sensitizing them in their life
and making them responsible towards different components of the Society and Environment. To this end, this article
recommends the human and social values inculcating programme for School Education Systems. In this article,
advantages of inculcating human and social values in school students are discussed. Furthermore, this article presents a
conceptual programme for inculcating human and social values in school students.This article is a conceptual paper that
builds upon the hallmarks of human and social values inculcating programme, absence of which is reflected and
manifested at every level in the society and the environment.A conceptual programme for inculcating human and social
values in school students is presented. A school education system that does not inculcate human and social values may
not have socially and environmentally conscious alumni and alumnae. A deliberate action to inculcate human and social
values in school students is urgently required.It is recommended that United Nations Educational,Scientific and Cultural
Organization (UNESCO) start an activity based Global School Students' Values Inculcation Programme (GSSVIP) across
the world to achieve its overarching objectives. The knowledge partnerships and the programme execution
partnerships can be done with bodies having a proven track record like Massachusetts Institute of Technology,
University of Oxford Jesuit Institutions, Stanford University etc. The other terms and conditions may be set as per the,
feasibility of different stakeholders.A pilot study can be conducted before the actual programme.Running programmes
for inculcating human and social values in school students is imperative to support a sustainable society and
environment.
A CASE REPORT ON MUCINOUS CYSTADENOFIBROMA OF OVARY IN POST HYSTERECTOMY
Authors: G Arthi. , Minnalkodi S. N. S.
Published: May 2022

Mucinous cystadenofibroma of ovary is a rare benign tumor. A 55-year old post-hysterectomy woman with ovarian
mucinous cystadenofibroma, diagnosed as benign cystic lesion prior to surgery. Patient successfully underwent
excision of cyst.
WETLAND INVENTORY, ASSESSMENT AND MONITORING
Authors: Narasimhaswamy Nalina , Dasappa Nalina , Rohit K.C. , Rangaswamy B.E. , SG Divakara , Manokaran Sumathra , Manjunatha Reddy A.H.
Published: May 2022

The destruction caused to natural resources by human activity to a certain extent is rectified by the wetland,but the pace
of disappearing wetland created a situation to find requisite program and tool for Wetland Inventory, Assessment and
Monitoring. Several organizations are working cumulatively designing methodologies and policies to restore and
improve the biotic characteristic. Wetland inventory provide guidance for the systematic collection of resource data
using both tradition manual and advanced remote sensing tools.WhereasWetland assessment includes identification of
ecological stature and extent threat caused.Wetland monitoring is collection of information of the assessment activities
as a result of the management and conducting surveillance in the existing and reduced threat.This review discusses the
various methodologies followed by different situations around the globe.
EFFECT OF CASTOR OIL ON GRAVIDA OF PREGNANT WOMEN WHEN USED AS A LABOUR INDUCTION AGENT
Authors: Aseri Rekha , Kumar Solanki Pankaj
Published: May 2022

Labour is an inevitable consequence of Pregnancy. Only two events can prevent the onset of labour once pregnancy has
become well established – the death of the undelivered mother or surgical removal of the fetus Castor oil is a herbal
4
preparation that has been used for induction of labor from ancient Egypt until now.
Castor oil is regarded as a uterine stimulant and irritant laxative
AIMS AND OBJECTIVES: EFFECT OF CASTOR OIL ON GRAVIDA OF PREGNANT WOMEN WHEN USED AS A LABOUR
INDUCTION AGENT
MATERIAL AND METHODS: 190 Patients admitted to labour ward of OBG Dept of MDM Hospital with an indication for
induction of labour.from MARCH 2019 to SEPTEMBER 2019
Method of Induction: This is a hospital based observational study which was conducted at Dr S N Medical College,
Jodhpur,Rajasthan by evaluating the women who were admitted in our hospital (MDMH)for delivery.
After informed consent had been obtained,the patients selected for the study were evaluated
Castor oil was administered in 2 doses form in 18-24hrs interval and every given dose is5047.75gm) in 200warm milk.Antiemetic drug was given 30 minutes prior to administered castor oil to minimize nausea and vomiting
RESULTS: 74 (71.15%) out of 104 multigravida women were successfully induced by castor oil. Among primigravida
women 36 (41.86%) out of 86 were successfully induced by castor oil. there were total 86 primigravida in the study
population and out of this 66 women has normal vaginal delivery 20 primigravida women who had caesarean section.
there were total 104 multigravida in the study population ,out of this 89 women has normal vaginal delievery
CONCLUSION: Castor oil is stable at room temperature and does not need refrigeration. Induction delivery interval,
requirement of Oxytocin augmentation is less in castor oil user.Vaginal delivery rate is high in castor oil user those use
castor oil as a labour inducing agent.
THE EFFECTIVENESS OF WRIST ROLLING EXERCISE AND ARM CYCLING IN COLLEGE STUDENT WITH HYPERMOBILITY OF WRIST JOINT- A COMPARATIVE STUDY
Authors: Anthoni. J Tamilarasan , Arun Mageswari
Published: May 2022

BACKGROUND: Hypermobility syndrome is different from localized joint hypermobility and other disorder that have
generalized joint hypermobility. Hypermobility syndrome occur also in genetic disorder. It is a condition where joint
laxity is associated with various musculoskeletal complaints. Exercise therapy at present has grown up to high standard
in treating the musculoskeletal disease and arm cycling improves maximum upper body strength and power. Hence the
study was done to evaluate the effectiveness of wrist rolling exercise and arm cycling in college student with
hypermobility of wrist joint.
MATERIALS AND METHODOLOGY: A Comparative study was conducted with a purposive Sampling technique.
Study Setting- KMCH institute of physiotherapy. A sample of 20 subjects between the ages of 18-25years, they were
allocated into 2 groups. Group-A with 10 individuals received wrist rolling exercise. Group-B with 10 individuals
received arm cycling.Outcome measures were reduction in wrist joint ROM and increase muscle strength.
RESULTS: Statistical analysis were done using independent 't'test and paired 't'test.There was a significant difference in
the both groups.On comparing the post-test values of Group-A and Group-B,it found that there was a significant effect in
Group A wrist rolling Exercise and Group B arm cycling.
CONCLUSION: From this study it is concluded that both exercise are very much effective in reducing the hypermobility
of wrist joint. But the wrist rolling exercise can be more effective in increasing the muscle strength in hypermobility of
wrist joint than arm cycling among college students.It is suggested that portable arm cycling can be used in home to get
better effect.
A STUDY ON THE RELATIONSHIP BETWEEN SELF-MONITORING AND ORGANIZATIONAL COMMITMENT AMONG COLLEGE TEACHERS, WITH SPECIAL REFERENCE TO MADURAI CITY
Authors: Nandhini B. , Anbugeetha D.
Published: May 2022

Organizational commitment is an individual person's psychological attachment towards the organization.
Organizational commitment plays a crucial part in determining holding back the employees in the organization.When
an employee stays with the organization for a longer period of time and works passionately towards achieving the overall
organizational objectives, it is said to be his/her organizational commitment. An employee's level of commitment
towards his/her work is considered as a vital factor to assess one's dedication to the tasks assigned.
There are several personal traits for organizational commitment, such as employee satisfaction, employee engagement,
self-monitoring, leadership, job performance, etc. However, it is very essential for every organization to understand that
how self-monitoring influences work-related behaviors like organizational commitment. Self-monitoring is an idea that
shows how much people monitor their self-presentations, expressive conduct, and non-verbal displays. People in
general,differ in various substantial ways in their capabilities and requirements to engage in expressive controls.
This empirical paper tries to bring out the relationship between self-monitoring and organizational commitment among
college teachers, with special reference to Madurai city. The researchers have conducted a survey and collected
responses from various college teachers in Madurai city.