bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening of New-Borns for Thyroid Status Admitted in Neonatal Ward of a Tertiary Care Hospital
Authors: Ahmed Shaheda , Ahmed Wazir , Uddin M Jalal , Aktar Feroza , Dutta Shanta , Rahman Ziaur , Hoque Afroza
Published: December 2022

Background: Neonatal screening program is very fruitful in saving our newborns from preventable neonatal diseases, thereby healthy grooming of future generations. Though newborn screening for a thyroid disorder is one of the greatest successes in preventive pediatrics but still has not practically worked out for all neonates in Bangladesh at the national level.The majority of newborns with a thyroid disorder have a normal appearance without detectable physical signs and are almost always missed. Screening at the proper time (Approximately 2-7 days after birth), rechecking of suspicious cases within a week, and initiation of treatment (Within 2 weeks of age) of thyroid disorders particularly Congenital Hypothyroidism (CH), can prevent the irreversible mental and physical impairments. Transient neonatal hyperthyroidism is the common form of neonatal hyperthyroidism. The purpose of the study was, Neonatal Screening (NS) to evaluate the rate of thyroid disorders among Preterm (Early preterm born before 34th week of gestation, late preterm born between 34th week and before 37th week of gestation), Term (Born within 37th to 42nd week of gestation) and Post-term (Born after 42nd week of gestation) newborns. Birth weight was alsomeasured to categorize the newborns according to their weight.

Materials and methods: It was a cross-sectional, observational type of study. The place was the Neonatal Department of Chattogram Maa-O-Shishu Hospital Medical College, Chattogram. Blood samples were collected from eighty neonates aging 2 to 7 days and sent to the laboratory for estimation of TSH and FT4.

Results: Total number of samples was 80. Out of them, preterm new-born were 19 and term new-born were 61, no post-term case was found. Both groups wereagain divided into normal birth weight (³2.5 kg) and low birth weight (< 2.5 kg). Hyperthyroidism (High or normal FT4 but low TSH) was observed in 23 term newborns (37.7%) and hypothyroidism (Low or normal FT4 but high TSH) in 11 term newborns (18.03%) and the rest were Euthyroid (TSH normal, FT4 normal/increased/decreased). In the case of preterm, there were more hypothyroid 03 (15.78%) than hyperthyroid 02(10.52%).

Conclusion: Our study observed that, among the newborns, who were admitted to the hospital,around half of them (39 out of 80) had abnormal thyroid function. The newborns with abnormal thyroid status were informed to their parents for further evaluation by the Department of Endocrinology. It would be helpful to reach the final diagnosis and treat it accordingly.

Chatt Maa Shi Hosp Med Coll J; Vol.21 (2); July 2022; Page 44-47
Clinical Profile of Patients with Bilateral Optic Disc Swelling Attending in an Apex Eye Hospital in Bangladesh
Authors: Rahat Ershadul H , Sarkar Shayamal K , Hossain Mujtahid M , Shimu Farjana S , Mostafiz Shafiul , Hossain Farzana
Published: December 2022

Background: Patient with optic disc swelling demands thorough ophthalmic as well as systemic evaluation as it may reflect intraocular as well as systemic diseases. Early diagnosis and proper management of bilateral disc swelling is important, as it can save vision as well as life. This study is aimed to determine the socio-demographic and clinical profile of patients with bilateral optic disc swelling in a tertiary eye hospital of Bangladesh.

Methods: This cross sectional study had been conducted over 102 patients with bilateral disc swelling at the Neuroophthalmology clinic of National institute of ophthalmology and Hospital, Dhaka between April 2019 and March 2020. Patients were selected purposively based on specific selection criteria. Detail history was taken, ocular examinations like visual acuity, color vision, field of vision, pupillary light reaction, fundus examination were done and relevant investigations included color fundus photograph, visual field analysis, Computed tomography scans and Magnetic Resonance Imaging were performed. All the information’s were recorded in a pre-designed data collection sheet.

Results: The mean age of the patients was 30.2±10.8 years where 37.3% patients were from 18-27 year age group. Females (67.7%) were commonly presented with bilateral disc swelling than male (33.3%). Most of the patients commonly presented with the symptoms like headache (71.6%), dimness of vision (62.8%), nausea & vomiting (42.2%), ocular pain (21.6%) etc. Best corrected visual acuity of the study population was within 0-0.3 log MAR unit in the right eye in 55.9% cases and in the left eye in 59.8% cases. Majority of the patients (Right eye: 60.8%, Left eye: 63.7%) could read all plates while color vision assessment. About 20% patient had RAPD. About 17% patients had field defect in their right eyes whereas about 15% had visual filed defect in left eyes. Other than disc swelling, 14 patients had diplopia (13.7%), 12 patients had uveitis (11.8%). Out of 102 patients, 36 patients were clinically diagnosed as IIH (35.3%). Others were diagnosed as ICSOL (24.5%), bilateral optic neuritis (12.7%), VKH (12.7%), grade-IV hypertensive retinopathy (8.8%). The analysis of neuro imaging findings among the patients showed 72 patients (70.6%) had no space occupying lesions, 9 patients (8.8%) had meningioma, 6 patients had CP angle tumor (5.9%), 5 patients had empty sella (4.9%).

Conclusions: Most of the Bangladeshi patients with bilateral disc swelling report to neuro-ophthalmology clinic in NIO&H are female and belong to 18-37 years age group. Among them headache is the most common presenting complaint and IIH is the most common clinical diagnosis.

J. Natl. Inst. Ophthalmol. 2022;5(1):39-45
Теоретичні основи модернізації організаційних форм навчання у ЗВО в кризових умовах
Authors: Козир Маргарита
Published: December 2022

Статтю присвячено дослідженню теоретичних основ модернізації організаційних форм навчання в закладах вищої освіти в кризових умовах. Авторкою проведено аналіз сучасних досліджень окресленої проблематики та визначено базові поняття дослідження. За основу взято наукові напрацювання представників Інституту філософії НАН України, що проводились під керівництвом М. Поповича (В. Іванов, С. Кримський, В. Мейзерський, Б. Парахонський), а також роботи вчених Інституту вищої освіти АПН України В. Андрущенка, В. Лутая, М. Михальченка, Г. Темка,.

Цілі статті: дослідження стану вивчення означеної проблематики; розгляд сутності ключових понять дослідження: «освіта», «модернізація освіти», «модернізація організаційних форм навчання»; обґрунтування актуальності модернізації організаційних форм навчання у ЗВО в кризових умовах.

У статті закцентовано увагу на тому, що динаміка змін у розумінні поняття «освіта», розширення його соціального та суспільного контексту пов’язане насамперед зі зростанням ролі освіти для життя сучасного суспільства. Сучасна освіта справді стає продуктивною силою та гарантом національної безпеки, а сучасна економіка стає дедалі залежнішою від знань кожної людини, оскільки основним засобом підвищення її ефективності є людські ресурси.

На думку авторки публікації, розвитку відкритих (віртуальних) університетів в Україні заважають наступні фактори: недостатній доступ до мереж та вартість доступу; відсутність законодавчої бази для створення та сертифікації віртуальних університетів та віртуальних структур у вищій освіті; витрати на комп’ютер, програмне забезпечення та розробку навчальних матеріалів; недосконалість системи оцінки знань для відкритої освіти; низький рівень інформаційної культури викладачів усіх рівнів та підготовка студентів до самостійного навчання.

У статті доведено, що поняття «модернізація освіти» досить широке, уніфікованого формулювання майже не існує. Як правило, зміст цього поняття зводиться до запровадження таких принципів Болонської системи освіти, як реформування, вдосконалення, поліпшення якості освіти тощо.
Кваліметричні критерії формування валеологічної компетентності в системі адаптивної освіти
Authors: Шевченко Олександр
Published: December 2022

Стаття присвячена валеологічної компетентності, яка полягає у спроможності здобувача вищої освіти вести здоровий спосіб життя, практикувати безпечні моделі поведінки та надавати долікарняну невідкладну допомогу людям у критичних станах, та кваліметричній моделі цієї компетентності. Аналіз законодавства України, міжнародних документів ООН та ВООЗ підтвердив актуальність здоров’язбереження на популяційному та особистому рівнях у зв’язку з задекларованою цінністю здоров’я. Запропонована кваліметрична модель враховує зміст навчальної програми академічної дисципліни «Педагогіка здоров’я», факт, що для успішного формування валеологічної компетентності потрібно вивчити повний курс дисципліни та рівноважний кваліметричний розподіл когнітивного, діяльнісного, мотиваційно-ціннісного та особистісного її компонентів. Тематичний розподіл вагових коефіцієнтів компонентів валеологічної компетентності, проведений методом експертних оцінок, дозволив визначити найбільш значущі теми дисципліні  «Педагогіка здоров’я», серед яких були теми профілактики хімічних залежностей, невідкладної допомоги, раціонального харчування. Кваліметрична оцінка успішності формування валеологічної компетентності у здобувачів вищої освіти може бути проведена як комплексно, так і за окремими компонентами. Зокрема, окремій оцінці підлягає спроможності надавати  невідкладну допомогу та вести здоровий спосіб життя. При цьому спроможність практикувати безпечні моделі поведінки може бути оцінена лише після навчання за всіма темам навчальної дисципліни. Сформована кваліметрична модель оцінки компетентності підлягає коригуванню за принципом зворотного зв’язку, що зазначено у якості перспективи подальших досліджень.  Також можливість коригувати модель є фактором полегшення адаптивного управління педагогічним процесом під час вивчення валеологічних дисциплін студентами немедичного профілю навчання.
Розвиток професійних компетентностей педагогів в умовах воєнного стану: управлінський аспект
Authors: Лузан Людмила
Published: December 2022

У статті проаналізовано практичний досвід Комунального вищого навчального закладу (КВНЗ) «Харківська академія неперервної освіти» щодо розвитку професійної компетентності педагогів в умовах воєнного стану, а саме: управлінський аспект. Визначено сутність поняття «адаптація», «адаптивність», «адаптивне управління». Розглянуто провідні ознаки адаптивного управління та сутність органічного поєднання мети керівника й прагнення виконавця на основі вироблення гнучких моделей діяльності; зазначені координаційні (партнерські) зв’язки, які переважають в адаптивному управлінні. Здійснено огляд наукових праць стосовно питання адаптивного управління в закладах післядипломної педагогічної освіти. Акцентовано увагу на розумінні адаптивності в професійній освіті як соціальної категорії, а саме те, що сучасний педагог має пристосуватися до змінних умов професійних викликів. Зазначено, що професійна адаптація педагога виявляється, формується й протікає не тільки в процесі педагогічної діяльності, а й під час підготовки до здійснення освітнього процесу, а значить, і під час підвищення кваліфікації, перепідготовки.

Окреслено шляхи здійснення освітнього процесу в умовах воєнного стану. Показано на прикладі КВНЗ «Харківська академія неперервної освіти» тісний взаємозв’язок, співпрацю, постійний діалог і взаємодію з освітянами Харківщини щодо підвищення кваліфікації та методичної підтримки. Надано за зразок комплексну програму, що має такі компоненти: цільова аудиторія, мета й завдання, основні напрями підвищення кваліфікації педагогічних працівників, форма підвищення кваліфікації, очікувані освітні результати навчання педагогів. Подано структуру програми на прикладі комплексної освітньої програми підвищення кваліфікації педагогічних працівників за напрямом «Українська мова та література», яка складається із 4 модулів. На основі анкетування щодо дистанційного навчання були визначені методичні рекомендації та пропозиції вчителям щодо здійснення освітнього процесі в умовах воєнного стану.

Акцентовано увагу на тому, що в умовах воєнного стану в країні адаптивне управління має стати пріоритетним, активно впроваджуватися в освітянське життя, педагоги мають активно вибудовувати участь у реалізації освітньої політики.
Особливості підготовки вчителів фізичного виховання в Китайській народній республіці
Authors: Цуй Лун
Published: December 2022

Корисним досвідом у контексті зазначеної проблеми є вивчення особливостей підготовки учителів фізичного виховання у країнах, де захопленість молоддю комп’ютерними іграми має дуже високий показник, наприклад, в Китаї. Така захопленість має шкідливий вплив на здоров’я підростаючого покоління, оскільки значно знижує його рухову активність. Китайський уряд здавна і до нині приділяє підвищену увагу фізичному вихованню та здоров'ю учнів, спортсмени з Піднебесної завжди демонструють високі результати на міжнародних змаганням. Окрім можливого забезпечення всіма необхідними навчальними засобами та сучасним обладнанням, в КНР особливо уважно пильнують формування вчительського контингенту.

          У ході наукового пошуку були оприлюднені чисельні нормативні акти, що безпосередньо пов’язані із роботою викладацьких кадрів в Китаї: «Стандарти фізичної підготовки», «Національні стандарти фізичної підготовки», «Правила проведення занять з фізкультури у навчальних закладах» та ін.

          У статті виокремлено основні особливості підготовки вчителів фізичного виховання, вивчено засоби контролю та апгрейду їхньої компетентності відповідно до сучасних положень у галузях освіти та охорони здоров’я країни. У роботі наведено загальний, основний та прогресивний плани підготовки майбутнього фахівця, розглянуто умови отримання професійно-кваліфікаційного сертифікату вчителя фізичного виховання та кваліфікаційного атестата вчителя фізичної культури. Результати дослідження представляють певний інтерес для вивчення та можливого подальшого творчого запозичення.
Strategi Komunikasi Pengenalan Krokot melalui FGD Desa sebagai Produk Potensial Kreatif Desa Wonosalam
Authors: Ghofur Muhammad Abdul , Mushollaeni Wahyu , Tantalu Lorine
Published: December 2022

Wonosalam Village in Wonosalam District, which is located in Jombang Regency, has abundant natural resources names Krokot. Unfortunately, it is only used as a house decoration material or to fill vacant land around the yard. The interesting thing that becomes a challenge when processing of Krokot (puslane) was how to reduce the "unpleasant" taste in food products. This study aims to find out how the communication strategy is to introduce purslane-based frozen food products. The research was conducted using a descriptive qualitative approach with the Focus Group Discussion method. The research found that the communication strategy was carried out by first determining the communicator, message or material, the media used, the audience and the expected feedback as in Harold Lasswell's concept. Not only that, the expected feedback has actually been planned from the start and achieved during the introduction of purslane, namely an understanding of the potential of purslane plants 92%, mastery of the stages of processing purslane-based food products 84%, and digitalization systems in marketing frozen food products based on purslane 76%.

Abstrak

Desa Wonosalam di Kecamatan Wonosalam yang berada di Kabupaten Jombang memiliki sumberdaya alam krokot yang melimpah. Sayangnya untuk pemanfaatannya hanya digunakan sebagai bahan penghias rumah atau pengisi lahan kosong di sekitaran pelataran. Hal menarik yang menjadi tantangan saat mengolah bahan dasar krokot adalah bagaimana mengurangi rasa “langu” pada produk makanan. Penelitian ini bertujuan untuk mengetahui bagaimana strategi komunikasi untuk mengenalkan produk frozen food berbahan dasar krokot. Penelitian dilakukan dengan menggunakan pendekatan kualitatif deskriptif dengan metode Focus Group Discussion. Penelitian menghasilkan bahwa starategi komunikasi dilakukan dengan terlebih dahulu menetapkan komunikator, pesan atau materi, media yang digunakan, khalayak dan feedback yang diharapkan sebagaimana dalam konsep Harold Lasswell. Tidak hanya hanya itu, feedback yang diharapkan sebenarnya sudah direncanakan sejak awal dan tercapai selama pelaksanaan pengenalan krokot, yaitu pemahaman mengenai potensi tanaman krokot 92%, penguasaan tahapan proses pengolahan produk pangan berbasis krokot 84%, dan sistem digitalisasi dalam pemasaran produk frozen food berbahan dasar krokot 76%.
Tensor Product of Phase Retrievable Frames
Authors: BOZKURT Fatma
Published: December 2022

Frame vectors in the tensor product of Hilbert spaces that accomplish phase retrieval can be characterized. In this article, we determine the conditions under which the tensor product of vectors may do phase retrieval. Given that tensor product of two frames always implies a frame in the tensor product of Hilbert spaces, we particularly concentrate on finding conditions for phase retrieval in the tensor product of Hilbert spaces.
Upaya Meningkatkan Etika Berbicara Pada Anak-Anak RT 16 RW 25 Perumahan Griya Bukit Jaya Gunung Putri Kabupaten Bogor
Authors: Samosir Astuti , Haryanti Ade Siti , Rejeki Suyekti Kinanthi
Published: December 2022

Pengabdian kepada Masyarakat yang dilaksanakan di Perumahan Griya Bukit Jaya, Gunung Putri, Kabupaten Bogor. Kegiatan ini bertujuan untuk memberikan pemahaman akan pentingnya etika berbicara pada Anak-anak RT 16 RW 25 Perumahan Griya Bukit Jaya Gunung Putri Kabupaten Bogor. Berdasarkan pengamatan sehari-hari yang dilakukan oleh ketua abdimas serta wawancara informal yang dilakukan terhadap ibu-ibu di RT 16 Perumahan Griya Bukit Jaya, banyak anak-anak yang menggunakan bahasa yang tidak sopan. Hasil kegiatan pengabdian ini sebagai berikut. Pertama,  mencari solusi terhadap permasalahan yang dihadapi oleh para ibu, terutama dalam menjaga emosi seorang Ibu di rumah. Seperti yang kita ketahui bahwa waktu anak bersama ibu lebih banyak dibandingkan ayah. Kedua,  permasalahan “bel”, disepakati akan memasang CCTV guna menjaga kenyamanan warga terutama yang memiliki bayi. Lalu, pada permasalahan orangtua yang tidak mau diberi saran, sebaiknya dilakukan pendekatan personal terkhusus tetangga samping rumah. Kemudian, anak-anak yang sudah terbiasa mengujarkan kata atau kalimat konteks “dewasa” maka orangtua serta semua warga sepakat memberikan pandangan secara bersama ketika mendengar kata atau kalimat tersebut.

Kata Kunci:Etika Berbicara, Anak-anak, Komunikasi
PENINGKATAN KOMPETENSI GURU SEKOLAH MENENGAH KEJURUAN DI KABUPATEN SUMBA BARAT DAYA
Authors: Limbong Mesta , Sitepu Ied Veda R , Kailola Lisa , Jojor Anita
Published: December 2022

Pelaksanaan kegiatan pelatihan dalam rangka peningkatan kompetensi guru di SMK Don Bosco, Sumba Barat Daya (SBD) serta guru eksternal berlangsung pada tanggal 26-27 Agustus

2022, di Sekolah SMK Don Bosco, SBD. Tujuan kegiatan adalah (1) sharing pengetahuan dan pengalaman; (2) terpetakannya kemampuan kompetensi guru, (3) dimulainya program peningkatan pengetahuan dan kompetensi mengajar para guru, dan (4) sebagai langkah awal perencanaan pengembangan kompetensi guru di Don Bosco, secara khusus dan di Tambolaka, secara umum. Kegiatan yang dilaksanakan adalah (1) observasi lapangan dan (2) FGD guru. Kompetensi guru, pedagogik, sosial, personal, dan profesional, harus diperkuat dan ditingkatkan. Mengingat lulusan SMK diharapkan dapat masuk ke dunia kerja, pengembangan SDM guru menjadi target prioritas, namun sarpras sementara tidak perlu mendapat perhatian karena secara kuantitas dan kualitas sudah memadai. Pelatihan guru yang diselenggarakan kemudian diarahkan untuk mencakup guru sekitar Tambolaka. Di akhir pelatihan, para guru membentuk forum komunikasi yang diharapkan dapat menjembatani komunikasi dan pencapaian misi pendidikan bersama-sama.
PEMBINAAN WARGA GEREJA BERKAITAN DENGAN AJARAN CALVINISME TENTANG TULIP KHUSUSNYA KONSEP “LIMITED ATONEMENT” DI GEREJA KRISTUS PETAMBURAN JAKARTA
Authors: Jura Demsy , Lesmana Liauw Fidelia , Zalukhu Amirrudin
Published: December 2022

Pembinaan Warga Gereja adalah sebuah kegiatan gereja yang bertujuan untuk pendewasaan iman anggota gereja, dan dengan pelaksanaan kegiatan ini diharapkan iman jemaat akan mengamalami pertumbuhan menunju kedewasaan hidup sebagai orang percaya. Gereja Kristus Petamburan memandang perlu dilaksanakan pembinaan doktrinal bagi warga gerejanya.  Dalam upaya pengembangan pelayanan kegerejaan, dan mempersiapkan warga gereja bagi upaya pendewasaan imannya, maka Gereja Kristus Petamburan menyelenggarakan kegiatan Seri Pembinaan Pentakosta dengan maksud mengajarkan keyakinan teologi Calvinisme kepada anggota jemaat.  Pembinaan Warga Gereja berkaitan dengan doktrin Calvinisme ini dianggap penting mengingat banyaknya keyakinan lain yang dapat memberi pengaruh buruk bagi mereka.  Istilah TULIP merupakan sesuatu yang penting dalam keyakinan Calvinisme dan hal itu perlu diajarkan, dimana salah satu kajiannya adalah Limited Atonement.  Kajian soteriologi Calvinisme menyangkut penebusan terbatas yang ada didalamnya.

Kata Kunci: Pembinaan Warga Gereja, Limited Atonement, dan Teologi Calvinisme
EVALUASI PROGRAM PEMBELAJARAN BINA DIRI ANAK TUNAGRAHITA DI SMALB SANTA LUSIA BEKASI KELAS XII PADA MASA PANDEMI COVID-19
Authors: Sulastri Sulastri , Tambunan Witarsa , Limbong Mesta
Published: December 2022

The self-development learning program is implemented to form the independence of children with special needs. The purpose of the study is to determine the needs assessment, to obtain a complete picture of the planning program, to describe the formative evaluation and summative evaluation of the self-development learning program for mentally retarded children at SMALB Santa Lusia Bekasi Class XII during the COVID-19 Pandemic. This study uses an evaluation method with a qualitative approach. The data obtained through observation and interviews were analyzed to evaluate the implementation of the self-development learning program. The research subjects were 7 students and 7 parent informants and 2 class teacher informants. The results of the research on the Need assessment aspect were carried out through the following procedures: 1) Observe all self-development programs. 2) Analysis of children's needs. 3) Determine priority programs. Aspects of the self-development program for mentally retarded children are: initial activities, core activities, and closing activities. Aspects of Formative evaluation, the overall self-development learning program was carried out well. The teacher consistently implements the planned program. However, there are two obstacles; 1) Teachers cannot accompany and guide directly. Even though all subjects still need guidance and direction during self-development learning takes place. 2) The participation of parents in the self-development learning program is still low, as evidenced by the implementation of the program most children are not accompanied by their parents. In the Summative evaluation aspect, the results shown in this evaluation are that the subject still needs guidance and direction in carrying out self-development learning activities, the dependence of mentally retarded students is still quite high. The impact: 1) Subjects are getting to know self-development tools and know how to take care of themselves. 2) Learning that took place during the COVID-19 pandemic indirectly educates students and their families about technological advances and their integration into learning.
REDUCING THE POLLUTION OF THE AIRSPACE OF THE CITY'S MAIN HIGHWAY AREAS
Authors: TATARCHENKO HALYNA , KRAVCHENKO INNA , TATARCHENKO ZAHAR , OZHEREDOVA MARYNA , BILOSHYTSKA NATALIIA , ZOLOTAROVA OLENA
Published: December 2022

The article deals with problems of air pollution in large cities and how to solve them. In Europe, road transport produces nearly half of NOx emissions, which ensures urban air quality. Analysis of reference data has revealed scientists' active interest in reducing air pollution in large cities. However, since the objects of territorial planning continue to develop dangerously, one can speak of the absence of a sufficiently compelling concept of architectural and urban planning to ensure the environmental safety of the air basin of urban areas. Therefore, we propose to consider the object of the research and protection as systemic integrity of three entities: areas near trunk roads, air basins, and population. The paper presents an ER model of the research object and determines the main parameters of each entity, their interrelationships, and the action area. We propose an engineering and planning solution for installing special units to remove the most dangerous admixtures of nitrogen oxides and dust from the air basin near the city trunk roads through ozonation and absorption. The basis of the proposed treatment plant is a scrubber with combined processes of wet dust collection and ozonation characterized by high efficiency in removing fine dust and nitrogen oxides. The work presents a process flow diagram of purification and determines the operating conditions of the equipment. To substantiate the unit's operational safety in an emergency with ozone emission, we have simulated the process of ozone dispersion in the surrounding areas.
Microprocessor device determining direction of sound to improve technical equipment at weaponry
Authors: Trach I. , Klym H. , Diachok R. , Karbovnyk I.
Published: December 2022

In this work development of an effective microprocessor device for determining the direction of the sound source with high accuracy and algorithm for calculating directions to the sound source were performed. The basis is a 32-bit STM32 microcontroller, which performs the necessary actions for the implementation of sound processing algorithms by the designed device. Electrical oscillations in analog form at the outputs of three microphones were used as input signals. The received signals are amplified by microphone amplifiers with a software-controlled transmission ratio to the nominal level of ADC operation. The use of such microphone sound amplifier with a software-controlled gain level made it possible to respond sensitively to the sound signal level of the environment and maintain the nominal level of the input signal at the ADC input. This approach made it possible to reduce the level of noise (at a low level of the input signal) and the level of signal distortion (at a powerful signal).

The device proposed in the work includes three remote microphones connected by a cable. The microphone amplifiers of each channel are divided into two parts. The first is placed near the microphone and converts the output signal into a differential signal with low internal resistance, the second is placed inside the device itself and converts the differential input signals into a normal form, removing interference of the common type. The amplifiers of the second part of the microphone amplifiers are software controlled, which allows adjustment to the nominal levels required by the ADC inputs. This design uses a built-in MCU ADC, which allows easy conversion of analog signals into digital form and process them according to the necessary algorithms. The obtained results are displayed on the display panel and transmitted over the Ethernet channel for further analysis. The full functioning of the device requires an autonomous power source to provide energy to all nodes.

The developed microprocessor device for determining the direction to the sound source can be used for military purposes with the joint use of algorithms and approaches to determining the direction proposed by other developers.
Etanercept embedded silk fibroin/pullulan hydrogel enhance cartilage repair in bone marrow stimulation
Authors: Song Xiongbo , Wang Xin , Guo Lin , Li Tao , Huang Yang , Yang Junjun , Tang Zhexiong , Fu Zhenlan , Yang Liu , Chen Guangxing , Chen Cheng , Gong Xiaoyuan
Published: December 2022

Background: Bone marrow stimulation (BMS) is the most used operative treatment in repairing cartilage defect clinically, but always results in fibrocartilage formation, which is easily worn out and needs second therapy. In this study, we prepared an Etanercept (Ept) embedded silk fibroin/pullulan hydrogel to enhance the therapeutic efficacy of BMS.

Methods: Ept was dissolved in silk fibroin (SF)—tyramine substituted carboxymethylated pullulan (PL) solution and enzyme crosslinked to obtain the Ept contained SF/PL hydrogel. The synergistical effect of SF/PL hydrogel and Ept was verified by rabbit osteochondral defect model. The mechanism of Ept in promoting articular cartilage repair was studied on human osteoarthritic chondrocytes (hOACs) and human bone marrow mesenchymal stromal cells (hBMSCs) in vitro, respectively.

Results: At 4 and 8 weeks after implanting the hydrogel into the osteochondral defect of rabbit, histological analysis revealed that the regenerated tissue in Ept + group had higher cellular density with better texture, and the newly formed hyaline cartilage tissue was seamlessly integrated with adjacent native tissue in the Ept + group. In cellular experiments, Ept treatment significantly promoted both gene and protein expression of type II collagen in hOACs, while decreased the protein levels of metalloproteinase (MMP)-13 and a disintegrin and metalloprotease with thrombospondin motifs 5 (ADAMTS5); alcian blue staining, type II collagen and aggrecan stainings showed that addition of Ept significantly reversed the chondrogenesis inhibition effect of tumor necrosis factor alpha (TNF-α) on hBMSCs.

Conclusion: BMS could be augmented by Ept embedded hydrogel, potentially by regulating the catabolic and anabolic dynamics in adjacent chondrocytes and enhancement of BMSCs chondrogenesis.
Identification of potential inhibitors of omicron variant of SARS-Cov-2 RBD based virtual screening, MD simulation, and DFT
Authors: Lü Xudong , Feng Cuiyue , Lü Ruijie , Wei Xiyu , Fan Shuai , Yan Maocai , Zhu Xiandui , Zhang Zhifei , Yang Zhaoyong
Published: December 2022

Emergence of the SARS-CoV-2 Omicron variant of concern (VOC; B.1.1.529) resulted in a new peak of the COVID-19 pandemic, which called for development of effective therapeutics against the Omicron VOC. The receptor binding domain (RBD) of the spike protein, which is responsible for recognition and binding of the human ACE2 receptor protein, is a potential drug target. Mutations in receptor binding domain of the S-protein have been postulated to enhance the binding strength of the Omicron VOC to host proteins. In this study, bioinformatic analyses were performed to screen for potential therapeutic compounds targeting the omicron VOC. A total of 92,699 compounds were screened from different libraries based on receptor binding domain of the S-protein via docking and binding free energy analysis, yielding the top 5 best hits. Dynamic simulation trajectory analysis and binding free energy decomposition were used to determine the inhibitory mechanism of candidate molecules by focusing on their interactions with recognized residues on receptor binding domain. The ADMET prediction and DFT calculations were conducted to determine the pharmacokinetic parameters and precise chemical properties of the identified molecules. The molecular properties of the identified molecules and their ability to interfere with recognition of the human ACE2 receptors by receptor binding domain suggest that they are potential therapeutic agents for SARS-CoV-2 Omicron VOC.
Inter-hospital transfer in patients with acute myocardial infarction in China: Findings from the improving care for cardiovascular disease in China-acute coronary syndrome project
Authors: Hu Danqing , Hao Yongchen , Liu Jun , Yang Na , Yang Yiqian , Sun Zhaoqing , Zhao Dong , Liu Jing
Published: December 2022

Background

Little is known about the current scenario of inter-hospital transfer for patients with acute myocardial infarction (AMI) in China.

Methods

From November 2014 to December 2019, 94,623 AMI patients were enrolled from 241 hospitals in 30 provinces in China. We analyzed the pattern of inter-hospital transfer, and compared in-hospital treatments and outcomes between transferred patients and directly admitted patients.

Results

Of these patients, 40,970 (43.3%) were transferred from hospitals that did not provide percutaneous coronary intervention (PCI). The proportion of patients who were transferred from non-PCI hospital was 46.3% and 11.9% (P < 0.001) in tertiary hospitals and secondary hospitals, respectively; 56.2% and 37.3% (P < 0.001) in hospitals locating in low-economic regions and affluent areas, respectively. Compared with directly admitted patients, transferred patients had lower rates of reperfusion for STEMI (57.8% vs. 65.2%, P < 0.001) and timely PCI for NSTEMI (34.7%vs. 41.1%, P < 0.001). The delay for STEMI patients were long, with 6.5h vs. 4.5h from symptom onset to PCI for transferred and directly admitted patients, respectively. The median time-point was 9 days for in-hospital outcomes. Compared with direct admission, the hazard ratios and 95% confidence intervals associated with inter-hospital transfer were 0.87 (0.75–1.01) and 0.87 (0.73–1.03) for major adverse cardiovascular events and total mortality, respectively, in inverse probability of treatment weighting models in patients with STEMI, and 1.02 (0.71–1.48) and 0.98 (0.70–1.35), respectively, in patients with NSTEMI.

Conclusion

More than 40% of the hospitalized AMI patients were transferred from non-PCI-capable hospitals in China. Further strategies are needed to enhance the capability of revascularization and reduce the inequality in management of AMI.
Teachers’ stress experiences during COVID-19-related emergency remote teaching: Results from an exploratory study
Authors: Vergine Ilaria , Gatti Flora , Berta Giulia , Marcucci Giulia , Seccamani Alice , Galimberti Carlo
Published: December 2022

The study provides a portrait of teachers’ stress experience in the face of the needed introduction of information systems (IS) during COVID-19-related emergency remote teaching. Researchers contacted the headmasters at several Italian schools, who choose teacher’s representatives. The latters shared the online questionnaire among colleagues; the teachers voluntarily decided to participate. The cross-sectional study involved 237 Italian teachers (81.5% female; Mage = 50.20; SDage = 8.87). This survey wanted to detect information systems-related distress and eustress on the job, and technostress creators and inhibitors. Descriptive statistics, correlational analyses, and a multiple regression model using structural equation modeling were run. As according to the model, IS-related distress and eustress on the job were the dependent variables, technostress creators and inhibitors the independent ones, and respondents’ gender and age the control ones. Both technostress creators and inhibitors showed significant relationships with IS-related distress and eustress. Technostress creators showed a positive relationship with IS-related distress and a negative one with IS-related eustress; conversely, technostress inhibitors showed an opposite pattern of relationships. Only technostress creators significantly associate to both age and gender in the model, suggesting that older, female teachers tended to experience more technostress creators. Due to the increases in remote work, the awareness of IS-related stress experiences represents a key factor to evaluate work-related risks and prevent stress-related problems. The results from this study suggest that using technologies can represent both a threat to one’s well-being, highlighting the need to provide adequate trainings and support, but also a resource for personal enrichment.
Microbiome alterations in women with gestational diabetes mellitus and their offspring: A systematic review
Authors: Farhat Sara , Hemmatabadi Mahboobeh , Ejtahed Hanieh-Sadat , Shirzad Nooshin , Larijani Bagher
Published: December 2022

Aims

Gestational diabetes mellitus (GDM) is a metabolic disorder that might predispose pregnant women to develop type 2 Diabetes Mellitus or lead to severe adverse outcomes in their offspring. One of the factors that have been thought to be involved in the pathology behind this disorder is the microbiome. In this systematic review, we comprehensively review the documents regarding the microbiota alterations in different tracts of pregnant women with GDM and their offspring.

Methods

A comprehensive search was conducted in major databases including MEDLINE (PubMed), Scopus, and Web of sciences up to August 2021. Data on the demographics, methodology, and microbiome alterations were extracted and classified according to the type of microbiome in pregnant women with GDM and their offspring. The quality of studies was assessed using the Newcastle-Ottawa Scale (NOS).

Results

In 49 articles which were retrieved, the findings were variable on the level of changes in alpha and beta diversity, enrichment or depletion in phyla, genera, species and OTUs, in each microbiome type. Although there were some inconsistencies among the results, a pattern of significant alterations was seen in the gut, oral, vaginal microbiome of women with GDM and gut, oral, and placental microbiome of their offspring.

Conclusion

Even though the alteration of the microbiome of the different tracts was seen in the cases of GDM, the inconsistency among the studies prevents us from identifying unique pattern. However, the results seem promising and further studies that overcome the confounding factors related to the demographics and methodology are needed.
Encoding diel hysteresis and the Birch effect in dryland soil respiration models through knowledge-guided deep learning
Authors: Jiang Peishi , Chen Xingyuan , Missik Justine E. C. , Gao Zhongming , Liu Heping , Verbeke Brittany A
Published: December 2022

Soil respiration in dryland ecosystems is challenging to model due to its complex interactions with environmental drivers. Knowledge-guided deep learning provides a much more effective means of accurately representing these complex interactions than traditional Q10-based models. Mutual information analysis revealed that future soil temperature shares more information with soil respiration than past soil temperature, consistent with their clockwise diel hysteresis. We explicitly encoded diel hysteresis, soil drying, and soil rewetting effects on soil respiration dynamics in a newly designed Long Short Term Memory (LSTM) model. The model takes both past and future environmental drivers as inputs to predict soil respiration. The new LSTM model substantially outperformed three Q10-based models and the Community Land Model when reproducing the observed soil respiration dynamics in a semi-arid ecosystem. The new LSTM model clearly demonstrated its superiority for temporally extrapolating soil respiration dynamics, such that the resulting correlation with observational data is up to 0.7 while the correlations of the Q10-based models and the Community Land Model (CLM) are less than 0.4. Our results underscore the high potential for knowledge-guided deep learning to replace Q10-based soil respiration modules in Earth system models.
Characteristics and physical mechanisms of a rainstorm in Hotan, Xinjiang, China
Authors: Yin Gang , Zhang Zhuo , Zhu Bojun , Li Qingxiang , Mao Min , Xing Wenyuan , Hu Zengyun , Chen Xi
Published: December 2022

Owing to global warming, extreme precipitation events in the arid regions of Central Asia have increased, resulting in significant consequences for water resources and ecosystems. Hence, to address the features and corresponding physical mechanisms of these rainstorms, we examined the rainstorm that occurred in Hotan, Xinjiang in June 2021 as a case study. We employed multiple datasets, including meteorological stations, sounding observations, satellite precipitation data, and reanalysis datasets. The results indicate that the Global Precipitation Measurement satellite precipitation product accurately captured the temporal and spatial variations in this rainstorm, as verified against hourly in situ observation data. Some meteorological stations recorded values greater than twice their historical records, such as Luopu, Pishan, Moyu, and Hotan. Moreover, the duration of the precipitation was longer than 2 days. For the physical mechanisms of this rainstorm, the water vapor in this rainstorm is sourced from the 45°–65°N region of the North Atlantic Ocean crosses the Ural Mountains and the West Siberian Plain to southern Xinjiang. The low-pressure levels (e.g., 700 hPa and 850 hPa) have the more water vapor flux and specific humidity than the high-pressure levels. Our findings can aid the understanding of extreme precipitation events in Central Asia and provide a reference for dealing with meteorological disasters, including extreme precipitation, in the context of global climate change.
Modelling the nexus of carbon dioxide emissions, economic growth, electricity production and consumption: Assessing the evidence from Pakistan
Authors: Ali Sajjad , Ghimire Amogh , Khan Adnan , Tariq Gulzara , Shah Ashfaq Ahmad , Tariq Muhammad Atiq Ur Rehman
Published: December 2022

The economy of Pakistan has constantly been plunged due to its severe electricity shortages over the last 2 decades and persistently faces challenges in revamping its electricity supply network. The purpose of this research was to assess the causal relationship between carbon dioxide emissions (CO2), combustible renewable and waste (CRW), electric power consumption (EC), electricity production from coal (EPC), hydroelectric (EPH) and natural gas (EPN) sources, energy use (EU) and gross domestic product (GDP). The scope of this research included Pakistan’s annual time series data from 1971 to 2014. This study employed Autoregressive Distributed Lag (ARDL) bound testing analysis to determine the long-term and short-term correlations among all research parameters. This research also conducted Augmented Dickey-Fuller (ADF), Phillips-Perron (PP) and Kwiatkowski-Phillips-Schmidt-Shin (KPSS) tests to evaluate the stationarity existence among dependent variable and independent variables. The outcomes of the fully modified least squares (FMOLS), dynamic ordinary least square (DOLS) and canonical co-integrating regression (CCR) estimators showed that coefficients of EC, EPH and GDP all were a significantly positive relationship with CO2 emissions, while the coefficients of CRW, EPC and EU were negatively significant, respectively. Furthermore, the outcomes from the short-run analysis revealed that the error correction term value was -0.8668, which indicates that from short-run to long-run equilibrium, the adjustment of the deviation of CO2 emission is by 86.68 percent annually. Moreover, the diagnostic results also demonstrated that the model employed in this research is stable and reliable. Pakistan was selected in this research work because of the deficit of power and if environmental degradation continues unchecked, it will eventually affect the state’s economic growth and CO2 emissions. The study’s primary policy recommendation is that government energy policymakers in Pakistan who create the environment framework in should pursue conservative energy measures as such measures will not negatively impact economic growth.
Environmental regulations, R&D intensity, and enterprise profit rate: Understanding firm performance in heavy pollution industries
Authors: Chen Meilan , Shi Victor , Wei Xiaobo
Published: December 2022

With the worldwide green revolution, especially “pollution prevention and control” as one major strategy, environmental issues have received more and more attention. Environmental regulations, as an institutional norm, directly or indirectly regulate corporate behavior. Therefore, it is significant to examine the relationship between corporate performance and environmental regulations. In this paper, we conduct an empirical study on the relationships among environmental regulations, R&D intensity, and enterprise profit rate. Our data are from the 395 A-share companies in heavy pollution industries listed on the Shanghai and Shenzhen Stock Exchanges in China from 2008 to 2017. Our methodologies include Ordinary Least Squares mixed regression, quantile regression, and Generalized Method of Moments estimation. Our main research findings include the following. First, environmental regulation and R&D intensity both have a positive impact on corporate profit rate at the 1% significance level. Second, there are “threshold” effects on the promotion of corporate profit rate by environmental regulations and R&D intensity. Third, the product of environmental regulation and R&D intensity has a positive impact on corporate profit margin at the 1% significance level. Fourth, the impacts of environmental regulations and R&D intensity on corporate profit rate vary at different quantiles. Finally, R&D intensity is a partial mediation variable in the relationship between environmental regulations and enterprise profit rate. In terms of policy insights, our results suggest that the government formulate appropriate environmental regulations and enhance the support for enterprise R&D to stimulate technological innovation in the heavy pollution industries.
Let’s end taxonomic blank slates with molecular morphology
Authors: Tessler Michael , Galen Spencer C. , DeSalle Rob , Schierwater Bernd
Published: December 2022

Many known evolutionary lineages have yet to be described formally due to a lack of traditional morphological characters. This is true for genetically distinctive groups within the amoeboid Placozoa animals, the protists in ponds, and the bacteria that cover nearly everything. These taxonomic tabula rasae, or blank slates, are problematic; without names, communication is hampered and other scientific progress is slowed. We suggest that the morphology of molecules be used to help alleviate this issue. Molecules, such as proteins, have structure. Proteins are even visualizable with X-ray crystallography, albeit more easily detected by and easier to work with using genomic sequencing. Given their structured nature, we believe they should not be considered as anything less than traditional morphology. Protein-coding gene content (presence/absence) can also be used easily with genomic sequences, and is a convenient binary character set. With molecular morphology, we believe that each taxonomic tabula rasa can be solved.
Ecological indication metrics on dung beetles metacommunities in native forests and Pinus monocultures
Authors: Simões-Clivatti Talita Rosa Otilia , Hernández Malva Isabel Medina
Published: December 2022

Beetles of the subfamily Scarabaeinae are commonly used as ecological indicators in studies about the effects of environmental changes. We analyzed the influence of the type of habitat, vegetation, mammals (as food resource), and temperature on dung beetle metacommunities in subtropical native forests and Pinus monocultures to evaluate the factors driving these assemblages. In the summer of 2018/2019, we sampled 12 areas in Southern Brazil, six Pinus monocultures and six native forests. We performed a dispersal test, applying a marking-recapture method. Some recaptures occurred in different habitats, showing low dispersal between habitats. We recorded behavioral activities confirming the use of both native forest and Pinus areas. The metrics did not reflect the difference in the environmental quality of the areas regarding species richness and diversity in different habitats. This shows that these metrics are not the best when using dung beetle assemblages as ecological indicators of biodiversity loss resulting from land-use changes, requiring complementing the analysis with composition analysis methods. When we partitioned beta diversity between habitats, we observed a dissimilarity between Pinus monocultures and native forest assemblages due to species substitution, with many species contributing to the dissimilarity between habitats. In our structural equation models, the influence of environmental factors on metacommunities showed no predictor related to dung beetle richness, but several variables influenced their abundance.