bluuebunny/crossref_metadata_2025 huggingface dataset:
Androgen Drives Melanoma Invasiveness and Metastatic Capacity by Promoting Tumorigenic Fucosylation
Authors: Liu Qian , Adhikari Emma , Lester Daniel , Fang Bin , Johnson Joseph , Tian Yijun , Mockabee-Macias Andrea , Izumi Vicky , Guzman Kelly , White Michael , Koomen John , Wargo Jennifer , Messina Jane , Qi Jianfei , Lau Eric
Published: March 2023

Melanoma incidence and mortality rates are historically higher for men than women. Although emerging studies have highlighted tumorigenic roles for the male sex hormone androgen and its receptor (AR) in melanoma, cellular and molecular mechanisms underlying these sex-associated discrepancies are poorly defined. Here, we delineate a novel mechanism by which androgen-activated AR transcriptionally upregulates fucosyltransferase 4 (FUT4) expression, which drives melanoma invasiveness by interfering with adherens junctions (AJs). Global phosphoproteomic and fucoproteomic profiling, coupled with in vitro and in vivo functional validation, further revealed that AR-induced FUT4 fucosylates L1 cell adhesion molecule (L1CAM), which is required for FUT4-increased metastatic capacity. Tumor microarray and gene expression analyses demonstrated that AR-FUT4-L1CAM-AJs signaling correlates with pathological staging in melanoma patients. By delineating key androgen-triggered signaling that enhances metastatic aggressiveness, our findings help to explain sex-associated clinical outcome disparities and highlight AR/FUT4 and its effectors as potential prognostic biomarkers and therapeutic targets in melanoma.
The Novel Phosphatase NUDT5 is a Critical Regulator of Triple-Negative Breast Cancer Growth
Authors: Qian Jing , Ma Yanxia , Tahaney William , Moyer Cassandra , Lanier Amanda , Hill Jamal , Coleman Darian , Koupaei Negar , Hilsenbeck Susan G. , Page Brent D. G. , Mazumdar Abhijit , Brown Powel H.
Published: March 2023

Background: The most aggressive form of breast cancer is triple-negative breast cancer (TNBC) which lacks expression of the estrogen receptor (ER), progesterone receptor (PR), and does not have overexpression of the human epidermal growth factor receptor 2 (HER2). Treatment options for women with TNBC tumors are limited, unlike those with ER-positive tumors, that can be treated with hormone therapy, or those with HER2-positive tumors, that can be treated with anti-HER2 therapy. Thus, we have sought to identify novel targeted therapies for TNBC. In this study, we investigated whether a novel phosphatase, NUDT5, is a potential therapeutic target.
Methods: TCGA and METABRIC (Curtis) datasets were used to investigate the mRNA expression levels of NUDT5 in breast cancers. NUDT5 ablation was achieved by targeting NUDT5 with siRNA, shRNA, and sgRNA and by inhibiting NUDT5 with the small molecule inhibitor TH5427. Xenograft animal models were used to determine the effect of NUDT5 inhibition on TNBC in vivo growth. Proliferation, death, and DNA replication assays were used to investigate the cell biologic effect of NUDT5 loss or inhibition. The accumulation of 8-oxoG and the induction of gH2AX after NUDT5 loss was determined by immunofluorescence staining.
Results: In this study, we demonstrated the important role of an overexpressed phosphatase, NUDT5, in regulating oxidative DNA damage in TNBCs. We found that NUDT5 loss led to suppressed growth of TNBC in vitroand in vivo. This growth inhibition was not induced by death, but instead by suppressed proliferation. Loss or inhibition of NUDT5 induced an increase in 8-oxoG and gH2AX lesions in DNA and a stall in DNA replication, thus inhibiting proliferation.
Conclusions: NUDT5 plays a critical role in preventing oxidative DNA damage in TNBC cells. Loss or inhibition of NUDT5 suppressed the growth of TNBCs. These biological and mechanistic studies provide a basic research foundation for the future development of NUDT5 inhibitors for the treatment of TNBC patients.
Comparison of the Effectiveness of Traditional Motorized Traction and Non-surgical Spinal Decompression Therapy Added to Conventional Physiotherapy in Low Back Pain
Authors: ADAR SEVDA , APAYDIN ONURHAN , DÜNDAR ÜMİT , TOKTAŞ HASAN , YEŞİL HİLAL , EROĞLU SELMA , EYVAZ NURAN
Published: March 2023

Abstract
Background: There are limited number of studies comparing non-surgical spinal decompression with other treatment options such as conventional motor traction in the treatment of low back pain caused by lumbar discopathy. This retrospective study aimed to compare the effectiveness of these treatments.
Methods: Retrospective data of patients who had physical therapy in our clinic with the diagnosis of lumbar dyscopathy were reviewed. Demographic datas, duration of their symptoms, physical examination findings, lumbosacral magnetic resonance imaging (MRI) reports, method and duration of treatment and Visual Analogue Scale (VAS) and Oswestry Disability Index (ODI) results were recorded.
Results: A total of 160 patients met the inclusion criteria. Their mean age was 44.6±12.4 (range 21-65) years, 57.5% (n=92) was female, and 42.5% (n=68) was male. There were no differences between the conventional physiotherapy, motorized traction, and spinal decompression groups in terms of age, duration of symptoms, and the number of sessions (p>0.05). In both three groups, the mean scores of VAS and ODI were significantly decreased in the pre-and post-treatment comparisons (p<0.005). The rates of change in VAS and ODI were higher in the traction group and spinal decompression group compared to the conventional treatment (p<0.005).
Conclusion: In patients with subacute and chronic lumbar dyscopathies, motorized traction and spinal decompression treatments added to conventional treatment were found to be more effective than conventional treatment alone. The results of spinal decompression and conventional motorized traction treatments appear to be similar.
Trial registration: ClinicalTrials.gov identifier number of the study is NCT05617924.
Keywords: Low back pain, intervertebral disc, traction, decompression
Fire Regimes Over a 1070-m Elevational Gradient, San Francisco Peaks/Dook’o’oosłííd, Arizona USA
Authors: Fulé Peter Z , Barrett Molly Peige , Cocke Allison E , Crouse Joseph E , Roccaforte John P , Normandin Donald P , Covington W Wallace , Moore Margaret M , Heinlein Thomas A , Stoddard Michael T , Rodman Kyle C
Published: March 2023

Background

Steep elevational gradients bring multiple forest types and fire regimes together in close proximity. The San Francisco Peaks/Dook’o’oosłííd in northern Arizona rise to 3,851 m elevation with slopes that span many of the major forest types of the southwestern U.S. mountains. To reconstruct past fire regimes across this broad elevational gradient, we sampled fire-scarred trees across the south face of the Peaks, complementing previous research on forest structure, composition, and origin of aspen stands.

Results

At the highest elevations, bristlecone pine forests had a mean fire interval (MFI) of 19.7 years prior to a modern fire exclusion period beginning after 1879. Other high-elevation (> 2,800 m) mixed conifer forests had MFI = 5.7 years and low-elevation (< 2,800 m) pine forests had MFI = 4.0 years. After 1879 there were no large fires through the end of the 20th century. Before 1879, fires occurred in the early to middle growing season. Fire regimes were linked to climate across all elevations, with a stronger association to drought (i.e., the Palmer Drought Severity Index) than to El Niño-Southern Oscillation phase. Pulses of forest regeneration were linked to the fire regime, with the largest pulse occurring shortly after fire exclusion. In addition to fire exclusion, other factors such as post-fire sprouting and regeneration after tree harvesting, likely contributed to the current dense forest structure on the Peaks.
Conclusions: Following over a century of fire exclusion, fire activity has increased on the Peaks over the past two decades, with large recent fires of uncharacteristic size and severity raising concerns about tree mortality, erosion, flooding, and infrastructure damage in surrounding human communities. Past fire regimes provide useful insight into fire-climate-forest interactions and the conditions under which existing forest communities were well adapted, but adaption to future conditions is likely to be challenging due to the rapid pace of projected environmental changes.
Digital Intervention Services to Promote Hiv Self-testing and Linkage to Care Services: a Bibliometric Analysis, Global Trends and Future Directions
Authors: Mhando Frank , Hatcher Genáe , Olughu Kelia , Hlongwa Mbuzeleni , Idahosa Love , Nyankomo Marwa , Conserve Donaldson F.
Published: March 2023

Background: It is imperative to identify and treat HIV-positive individuals that are unaware of their status to achieve the UNAIDS goal of eliminating HIV worldwide by 2030. The use of digital tools such as website-based systems, social media, mobile apps, Short Message/Messaging Service (SMS), and vending machines (VM) could expand access to HIV self-testing (HIVST) and enhance post-test linkage to care services. This study aims to analyze the progress of digital interventions in HIVST and linkage to care services, assess the impact of scholarly work in the context of scientific production, and compare the relative scientific contributions of scholars, countries, research groups or institutions.
Methods: We searched the literature in the Web of Science (WoS) database within a period of 2011 to 2022 and conducted a bibliometric analysis. The search was conducted on 10th December 2022. The key words used were mobile health, HIV self-testing and Linkage to care. This paper uses VOS viewer and bibliometrix to perform bibliometric analysis.
Results: For the keyword search, a total of 117 documents were gathered of which only 91 documents have been considered for the analysis. Among 91 documents, 79 were articles and 12 were reviews. The United States, South Africa, United Kingdom and China are the most productive and influential countries, with the widest range of collaborative partners. Other key findings are presented and discussed, followed by some potential future research avenues.
Conclusion: Based on the data collected from the WoS, digital transformation and HIV self-testing is a relatively new field, as the first paper published on the topic only dates to 2011 however, the trend of production kept increasing every year which is eloquent proof that the field is attracting a great number of researchers and scholars.
AMOC decline and recovery in a warmer climate
Authors: Nobre Paulo , Veiga Sandro , Giarolla Emanuel , Marquez André , Silva Manoel , Capistrano Vinícius , Malagutti Marta , Fernandez Julio , Soares Helena , Bottino Marcus , Kubota Paulo , Figueiroa Silvio , Bonatti José , Sampaio Gilvan , Casagrande Fernanda , Costa Mabel , Nobre Carlos
Published: March 2023

This study presents novel insight into the mechanisms of Atlantic Meridional Overturning Circulation (AMOC) reduction and its recovery under a warmer climate scenario. An one-thousand-year-long numerical simulation of a global coupled ocean-ice-atmosphere climate model, subjected to a stationary atmospheric radiative forcing, depict a coherent picture of the Arctic sea ice melting as a trigger for the initial AMOC reduction, along with decreases in the northward fluxes of salt and heat. Further atmospheric-driven ocean processes contribute to an erosion of the stable stratification of the fresher, yet colder waters in the surface layers of the North Atlantic, contributing to the recovery of a permanently altered AMOC.
The Environmental Sustainability of the European Union countries: Collective Identity as a Stratum for Decarbonization
Authors: DIKE GLORY , Direkli Mehmet
Published: March 2023

To stay within a “well below 2°C” climate change track, the Paris Agreement and goal 13 of the Sustainable Development Goals (SDGs) call for climate action - a global decrease in Green House Gases (GHG) emissions. Arguments in this study are derived from the hypothesis that a collective identity among the EU states would foster collective actions toward reducing global warming. Thus, the objective of this study is to explore how different EU countries (Poland, Italy, and Germany) employs three decarbonization pillars: waste recycling, eco-innovation, and policy innovation (WEP) as a yardstick to mitigate global warming and attain the EU’s “net-zero” emissions by 2050. The study also utilizes annual data collected from the Eurostat indicator from 2014 to 2020. The findings reveal that Germany has the most successful average recycling rate in Europe; 65.5 percent of the country’s domestic waste is either recycled or reused. On the other hand, Poland is a low performer in eco-innovation. Additionally, an analysis of policy regulations reveals that both Germany and Italy can comply with the policy and regulations of the EU on carbon neutrality. At the same time, Poland, on the other hand, lacks the commitment to carbon neutrality due to its reliance on carbon-intensive coal. Therefore, this study recommends translating EU climatic laws in their simplest forms into local laws. Moreso, citizens' behavior will be further influenced toward environmental sustainability by this collective mindset.
Sexual and reproductive health rights and service use among undocumented migrants in the EU: a systematic literature review
Authors: Mandroiu Alexandra , Pavlova Milena , Groot Wim
Published: March 2023

Background
Most EU member states fail to provide comprehensive access to essential sexual reproductive health services to undocumented migrants. This population group is, therefore, specifically vulnerable to experiencing worse health outcomes related to sexual and reproductive health. The aim of this study is to systematically review the academic literature on the access to and use of sexual reproductive health services as well as related health outcomes for undocumented migrants in the EU.
Methods
We systematically searched PubMed, Embase, and Cinahl/Ebsco to identify quantitative, qualitative, and mixed methods studies published between 2017 and 2022 (last 5 years).
Results
A total of 996 records were retrieved. The deduplication left 814 studies. After screening titles, abstracts, and full texts according to pre-defined inclusion and exclusion criteria, 37 articles were included in the review. Overall findings indicated a variety of access barriers such as refusal of care, lack of knowledge and information on national healthcare provision schemes, bureaucratic and administrative hurdles, as well as affordability difficulties. Even when sexual reproductive health services were available and accessible, the studies reported a variety of factors affecting the use of such services by undocumented migrant populations, e.g., stigma, fear of deportation, socio-economic precarity, or abuse. All this translates into generally reported worse reproductive health outcomes for this population group.
Conclusion
Although it is hard to generalize the present findings to the EU region, this review furthers the evidence that undocumented migrants in Europe face worse reproductive health outcomes related to barriers to access and utilization of reproductive health services.
Functional state and rehabilitation of patients after primary brain tumor surgery for malignant and non-malignant tumors: a prospective observational study
Authors: Krajewski Stanisław , Furtak Jacek , Zawadka-Kunikowska Monika , Kachelski Michał , Soboń Jakub , Harat Marek
Published: March 2023

Background: There have been several attempts to develop rehabilitation programs for brain tumor patients with poor quality of life, but these studies usually failed to take tumor malignancy into account. Determining the functional status throughout postoperative recovery would help us to understand the dynamics and effectiveness of rehabilitation, and taking tumor type into account may help to preselect patients for rehabilitation services or prioritize needs. The aim of this study was to compare the pre- and post-operative function of patients qualifying for initial resection of malignant and non-malignant primary brain tumors to determine the relationship between tumor type, function, and the course of rehabilitation after surgery.
Methods: This was a single-center, prospective, observational study (two intervention groups) conducted in a tertiary neurosurgical inpatient unit. Ninety-two patients required prolonged postoperative rehabilitation during their inpatient stay and were divided into a non-malignant tumor group (n=66) and a malignant tumor group (n=26). The Karnofsky performance status, Barthel index, and the modified Rankin scale were used to assess functional status, while the gait index was used to assess gait efficiency. Motor skills, postoperative complications, and length of hospital stay (LoS) were recorded and compared between groups.
Results: The frequency and severity of postoperative complications, the time needed to attain individual motor skills, and the proportion of patients who lost independent gait (~30%) were similar between non-malignant and malignant groups. However, paralysis and paresis were more frequent in the malignant tumor group before surgery (p<0.001). While non-malignant tumor patients deteriorated more according to all scales after surgery, patients with malignant tumors were still characterized by worse ADL, independence, and performance at discharge. Worse functional outcomes in the malignant tumor group did not affect LoS or rehabilitation.
Conclusions: Patients with malignant and non-malignant tumors have similar rehabilitation needs, and patient expectation – especially those with non-malignant tumors - should be appropriately managed. Counterintuitively, patients with non-malignant tumors might require more rather than less counselling and support given their greater deterioration after surgery.
A Study of Knowledge on Alzheimer's Disease and Attitudes of Chinese Social Residents towards Alzheimer’s disease: a cross-sectional survey in China
Authors: Rui Lu , Ning Qiao , Jin Song , Ziqiong Wang , Jiarui Zhao , Ruxia Yu , Qiucheng Wang , Jing Jiang
Published: March 2023

objective:Social residents become increasingly concerned about Alzheimer's dementia (AD) as a global public health crisis. China's AD population is the largest and growing fastest. However, no study has examined Chinese social residents' knowledge and attitudes concerning Alzheimer's illness. This study examined Chinese social residents' AD knowledge and attitudes using the ADKS and DAS.Study design:Cross-sectional survey. 338 social residents over 18 from various Chinese regions were recruited using convenient sampling.Method:The Alzheimer's Disease Knowledge Scale (Chinese) and the Dementia Attitude Scale (Chinese) were used to assess their knowledge and attitude regarding AD.Results:A total of 328 respondents (97.04%) completed the survey. ADKS = 19.44±3.33; DAS = 86.98±12.7. Age and education level can have a substantial impact on ADKS scores, and education level can have a substantial impact on DAS scores.Conclusion:Low levels of awareness and acceptance of AD exist among Chinese residents. The results indicate that China must immediately implement comprehensive AD education for its social residents.
Cross-modal Retrieval based on Shared Proxies
Authors: Wei Yuxin , Zheng Ligang , Qiu Guoping , Cai Guocan
Published: March 2023

Inconsistency of distribution and representation across different data modalities makes measuring cross-modal similarities a very difficult problem. Learning a common space that is semantically discriminative and modality invariant is the main challenge in cross-modal retrieval. Existing solutions usually employ pairwise or triplet data relationships to learn the common space, which can only capture the data similarity locally but would be unable to effectively characterize the global geometry of the common embedding space, and thus would limit the performance of cross-modal retrieval. In this paper, we introduce a shared proxy solution to cross-modal retrieval. We propose to incorporate the principles of shared proxy with neighbourhood component analysis to learn a common space for different modalities in which the distance between a sample’s representation and its corresponding proxy is minimized while the distances between a sample’s representation and the proxies not belonging to the sample are maximized. We propose the Cross-mOdal proXy learnIng (COXI) framework which integrates a cross-modal shared proxy loss, a discriminative loss and a modality invariant loss for supervised cross-modal retrieval. Extensive experiments on benchmark datasets clearly shows that COXI outperforms state of the art cross-modal retrieval techniques. Code is available on https://github.com/LigangZheng/COXI.
Exploratory Analysis of Space Components in Starbucks Stores
Authors:   Korea Urban & Real Estate Association, Jeong Yeun-Jeong , Park Tae-Won
Published: March 2023

This study examined the spatial characteristics of Starbox stores through exploratory factor analysis that discovers detailed spatial components based on the spatial experience experienced by visitors to Starbucks general stores. As a result of the analysis, a total of five factors were grouped and derived, and each factor was named as ‘culture/artistry’, ‘five senses/hospitality’, ‘behavior/psychology’, ‘taste/hardware’, and ‘lead/pandemic’. Through exploratory factor analysis based on the visitor's experience, the significance of this study was able to identify the cause of continuous visits to Starbucks stores and infer detailed components related to Starbucks' third place, which shows a commercialized space but differentiated place. This is a strategic projection of Starbucks' corporate philosophy and ideology into space and place, and it is judged that this positioning is perceived and experienced by the visitor group through five senses.It is judged that these attributes will be a very important space and place strategy for commercial real estate, especially retail real estate, which requires continuous visits. As a future research topic, the factors derived through exploratory factor analysis are independent variables, and it is necessary to measure dependent variables for visitor satisfaction and revisit intention, and to analyze visitors by group to examine the differences.nalyze visitors by group to examine the differences.
A study on the difference in the future residence probability of residents, and the effect of housing tenure choice and period of residence on them in small and medium-sized cities: Focused on Gyeongsangnam-do
Authors:   Korea Urban & Real Estate Association, Jo Joon Hyok
Published: March 2023

The purpose of this study is to compare between cities‘ the possibility of 'continuing to live in the city where you currently live', and to analyze the extent to which differences in living conditions affect the possibility. An empirical analysis was conducted using data from 18 cities and counties in Gyeongsangnam-do and 15,000 households. A binary logit model was used. Among the 18 cities and counties in Gyeongsangnam-do, the cities and counties that had the greater possibility of continuing residence than Changwon-si were Miryang, Yangsan, Uiryeong, Changnyeong, Goseong, Hadong, Hamyang, Geochang, and Namhae. On the other hand, the smaller cities and counties were Geoje, Hapcheon, and Gimhae. Compared with those whose tenure type is their own house, the probability of continuous residence for those living in the rented house is smaller. The longer the period of residence in Gyeongsangnam-do and Gyeongsangnam-do cities and counties, the more likely they are to continue living.
A QUASI EXPERIMENTAL STUDY TO ASSESS THE EFFECTIVENESS OF BREAST MASSAGE IN REDUCING BREAST ENGORGEMENT AND PAIN AMONG POSTNATAL MOTHERS ADMITTED IN REGIONAL HOSPITAL UNA 2022
Authors:   Professor Cum Principal, HIMCAPES College Of Nursing Badhera Una HP., Kaur Varinder , Rani Nisha ,   Assistant Professor, HIMCAPES College Of Nursing Badhera Una HP.
Published: March 2023

Background: Breast engorgement is defined as the swelling and distension of the breasts. The common causes of engorged breasts are congestion of fluid and blood in the breast. Adequate management of engorgement is important for successful long-term lactation. The goal of treatment of breast engorgement is to relieve discomfort and control swelling. Objectives: The Investigator conducted the study with an objective to assess the effectiveness of breast massage in reducing breast engorgement and pain among postnatal mothers admitted regional hospital, Una. Methodology: A Quantitative approach and quasi experimental research design was adopted to conduct the study. Sample of 50 postnatal women selected in postpartum ward in RH Una by purposive sampling techniques. The data is collected by semi structured questionnaire and universal pain assessment tool. The collected data was analysed and interpreted by using descriptive and inferential statistics. Result- This study revealed that the mean of Breast engorgement pre- test in experimental group among postnatal mother 4. 16 . The mean percentage is 69. 3% and the SD is 1. 43. The mean of Breast engorgement pre- test in control group among postnatal mothers is 4. 12 ,The mean percentage is 68% and SD is 0. 745, The mean of breast pain pre- test in experimental group among postnatal mother 4. 79 ,The mean percentage is 49. 7% and the SD is 2. 026 . The mean of breast pain pre- test in control group among postnatal mother 4. 28, the mean percentage is 42. 8% and SD is 1. 59474, The mean of pre- test in experimental group among postnatal mother 1. 08 , the mean percentage is 30%and the SD is 0. 8164. The mean of pre- test in control group among postnatal mother 3. 24, the mean percentage is 54% and SD is the mean of post - test in experimental group among postnatal mother is 1. 08, The mean percentage is 10. 8 % and the SD is 1. 2219 .The mean of post- test in control group among postnatal mother 4. 64, the mean percentage is 46. 4 % and SD is 1. 97230. Conclusion- The Study concluded that the massage shows good result on reliving engorgement and pain.
ENERGETIC POWER ESTIMATION OF SWELLS AND ORBITAL MARINE CURRENTS IN BENIN COASTAL ZONE (GULF OF GUINEA)
Authors:   National Superior Institute of Preparatory Classes for Engineering Studies (INSPEI / UNSTIM) Abomey BP 2282, Republic of Benin., Noukpo Bernard TOKPOHOZIN ,   Institute of Mathematics and Physical Sciences IMSP/UAC) 01BP 613 Porto-Novo, Republic of Benin.,   Laboratory of Sciences, Engineering and Mathematics (LSIMA/UNSTIM), Abomey BP 2282, Republic of Benin., Jean-Louis C. FANNOU ,   Laboratory of Sciences, Engineering and Mathematics (LSIMA/UNSTIM), Abomey BP 2282, Republic of Benin., H. Guy HOUNGUE ,   Laboratory of Radiation Physics FAST-UAC 01BP 526 Cotonou Republic of Benin.,   Department of Physics (FAST) and Doctoral Training in Materials Science (FDSM / UAC) Calavi, Republic of Benin., A. Mathias HOUEKPOHEHA ,   Institute of Mathematics and Physical Sciences IMSP/UAC) 01BP 613 Porto-Novo, Republic of Benin.,   Laboratory of Radiation Physics FAST-UAC 01BP 526 Cotonou Republic of Benin., B. Basile KOUNOUHEWA ,   Institute of Mathematics and Physical Sciences IMSP/UAC) 01BP 613 Porto-Novo, Republic of Benin.,   Laboratory of Radiation Physics FAST-UAC 01BP 526 Cotonou Republic of Benin.,   Department of Physics (FAST) and Doctoral Training in Materials Science (FDSM / UAC) Calavi, Republic of Benin.
Published: March 2023

The announced depletion of fossil energy resources is fueling some speculation. It is therefore urgent to explore the different renewable energy sources available to Benin. In the ocean, in addition to swells, there are also orbital marine currents generated by them. An advantageous solution for the countries located in the Gulf of Guinea is the recovery and transformation of the energy of the swell and its orbital marine currents into electrical energy. Swells are adult waves that propagate freely at the atmosphere-ocean interface. In this work, based on measurements made by the Millenium Challenge Account (MCA-Benin) as part of the extension of the Autonomous Port of Cotonou, we have shown that the swells at the Autonomous Port of Cotonou are Airy swells or of Stokes. We have identified the modified Boussinesq equations, proposed by Peregrine in 1967, as the theory for characterizing the evolution of these swells during their formation in the coastal zone. The variations of the different wave parameters (height, wavelength, period, phase and group velocities) are characterized from the shoaling zone to the breaking point. With this theory the results obtained are in agreement with the experimental measurements made, they perfectly describe the amplification of the height of these waves and show that these swells become very energetic when they approach the coast.
HEMOXIGENASE-1, IRON, AND BILIRUBIN LEVELS AS OXIDATIVE STRESS INDICATORS OF COLLOIDAL SILVER EXPOSURE IN HUMAN LYMPHOCYTES
Authors:   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico, Centro., Lagunes Lucerito Esmeralda Avila , Rodriguez Elda Maria del Rocio Coutino ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico, Centro., Omar Arroyo-Helguera ,   Biomedicine in public health Laboratory, Public Health Institute, Universidad Veracruzana. Av. Luis Castelazo Ayala S/N, Col. Industrial Animas, Xalapa, Veracruz CP. 91190, Mexico, Centro.
Published: March 2023

Introduction:Colloidal silver and nanoparticles (AgNPs) are used to disinfect fruits and vegetables as well as to purify water. Its consumption induces oxidative stress and activate antioxidant mechanisms such as catalase and heme oxygenase-1 (HO-1) at cellular level. The HO-1 attenuatesthe toxic effectsof metals andROSinvolved inchronic degenerative diseases. Objective: Analyze the effects of Fe++ and bilirubin, products of HO-1 induction by exposure to Colloidal Silver (CS) and its association with oxidative stress parameters Methods: A primary human lymphocytes were exposed to different doses 0.036Î¼g /mL, 0.36Î¼g/ mL and 3.6 Î¼g/mL of colloidal silver and after of 0.5, 2 and 24 hrs, and HO-1 and its productsironand bilirubin were measurement, also protein levelsby colorimetric methods. Data wereanalyzed usingSPSS software, version18,to determinethe association betweenthe parameters Results: TheCS increases HO-1 activity and was associated with bilirubin and iron R=0.518, p=0.0001. Moreover, ironwas associated with proteins levels, r=0.585 p0.0032, hydroxides r=0.390 p0.002, 8 â€“Iso r= 0.254 p.054, HO-1 r=0.518 p.0001, bilirubin r=.569 p.002 and tend to associate with cell viability r=-0.227 p.082. Also, Fe at theconcentration of 0.036Î¼g/mL and low time exposurepresents association almost with all markers. Conclusion: Colloidal silver at low concentration and times exposure induce HO-1 highly associated with bilirubin and Fe++, which plays an important role when triggering oxidation damage in the membranes,related with citotoxity. These results can be useful tools to study through Fe the OS development in the chronic degenerative diseases, by exposure to xenobiotics such as CS.
UROTHELIAL BLADDER CANCER IN YOUNG PATIENTS UNDER 40 YEARS OLD
Authors:   Urology Departmentof the University Hospital of Sous-Massa, Agadir, Morocco., Dergamoun Hamza , Jalal Ossama ,   Urology Departmentof the University Hospital of Sous-Massa, Agadir, Morocco., Taoufiq Aadil ,   Urology Departmentof the University Hospital of Sous-Massa, Agadir, Morocco., Ziouziou Imad ,   Urology Departmentof the University Hospital of Sous-Massa, Agadir, Morocco.
Published: March 2023

Bladder cancer is the 2nd urological cancer, most known in people over 50 years old. We are witnessing increased number ofcases in subjects under 40 years of age, mostly due to several factors. The purpose of our study is to study the pathologic and clinical features of urothelial tumors of the urinary bladder in young patients and to understand the particularity of this entity.Retrospective, descriptive study, on 17 patients, treated at two centers, the urology department of the University Hospital of Souss-Massa (Center A) and Urology department ofUniversity Hospital Ibn Sina in Rabat (Center B).From March 1, 2019 to March 1, 2022.This study concerns 17 patients hospitalized in center A and B with an average age of 35 years, sharing the same risk factors. the pathology was revealed by hematuria. our patients benefited from an initial TUR-V resection, the follow-up was then based on the results of anatomopathology.These tumors were preferentiallylocalized on the lateral face of the bladder, and retrotrigone with an average size of 3 cm in both centers. The most common histologic type wasurothelial carcinomapTa Low Grade in both centers. Bladder tumors in young people are unusual, favored by the presence of risk factors. However, these factorscannot be incriminated due to the short exposure time. Superficial bladder tumors seem to have a good prognosis with little recurrenceunlike infiltrating tumors.
A COMPARATIVE EVALUATION OF VESTIBULAR INCISION SUBPERIOSTEAL TUNNEL ACCESS (VISTA) VERSUS CORONALLY ADVANCED FLAP WITH COLLAGEN MEMBRANE FOR THE TREATMENT OF MILLERS CLASS I AND CLASS II GINGIVAL RECESSION: A CLINICAL STUDY
Authors: Kabra Ritika , Sethi Lakshay , Sekhar Vidya , Malhotra Sumit , Kaul Anisha , Tyagi Varun
Published: March 2023

Background: Gingival recession is defined asThe displacement of soft tissue margin apical to CEJ with exposure of root surface. Factors such as abnormal tooth alignment in the arch, fenestration, dehiscence, faulty tooth brushing, periodontal diseases etc. are few of the causes of gingival recession. The aim of the present study was to compare the effectiveness of minimally invasive Vestibular Incision Subperiosteal Tunnel Access (VISTA) technique and coronally advanced flap using a bioresorbable collagen membrane in Millers Class I and II gingival recessions Material and Methods: 20 sites with Millers Class I or II gingival recession were recruited and allocated into 2 groups with 10 sites each. Test group: VISTA with bioresorbable collagen membrane control group: CAF with bioresorbable collagen membrane. Plaque Index (PI), Gingival Index (GI), relative Clinical attachment level (CAL) Pocket Probing Depth (PPD) Recession Height (RH) and width of keratinized gingiva (WKG) Recession Width (RW) were measured at baseline 3 months and 6 months. Results: A significant improvement was found in all the clinical parameters in the Test group from baseline to 3 months and 6 months Recession width reduction was significantly more in the Test group as compared to Control group. Conclusion: Both the groups, viz: VISTA with resorbable collagen membrane and CAF with resorbable collagen membrane were effective in the treatment of Millers Class I and II gingival recessions VISTA being minimally invasive can be used for covering recession defects.
DIFFICULTES DIAGNOSTIQUES DE LA SARCOIDOSE OCULAIRE CHEZ LENFANT: A PROPOS DUN CAS
Authors:   Service DophtalmologieB, Hopital Des Specialites De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc., Nadaa Tebay , Hafidi Naima El ,   ServiceImmunoallergologie Et PneumologiePediatrique, HopitalDes Enfants De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc., Salma Hassina ,   Service DophtalmologieB, Hopital Des Specialites De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc., Louai Serghini ,   Service DophtalmologieB, Hopital Des Specialites De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc., Elhassan Abdallah ,   Service DophtalmologieB, Hopital Des Specialites De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc., Hamani Amina Berraho ,   Service DophtalmologieB, Hopital Des Specialites De Rabat, CHU IBN SINA, Universite Mohamed V, Maroc.
Published: March 2023

Sarcoidosis is a multi-systemic granulomatosis of undetermined etiology often affecting young adults and difficult to diagnose. It is rare in children and can be misleading. We report the case of a 7-year-old child who objectifies this diagnostic difficulty, especially the differential diagnosis with ocular tuberculosis while underlining the importance of the collaboration of the ophthalmologist with the pediatricians and the anatomopathologists because of the frequency and the polymorphism of this ocular affectionunder-diagnosed in children.
FUNCTIONAL OUTCOME OF NEGLECTED POSTERIOR ELBOW DISLOCATION MANAGED SURGICALLY BY OPEN REDUCTION IN A NORTH-EAST TERTIARY CENTRE OF INDIA
Authors:   Post-Graduate Trainee, Dept. Of Orthopaedic Surgery, AGMC & GBPH, Tripura., Ranjan Shashi , Majumder Avisek ,   Senior Resident, Dept. Of Orthopaedic surgery, AGMC & GBPH, Tripura., Reang Santosh ,   Associate Professor, Dept. Of Orthopaedic Surgery, AGMC & GBPH, Tripura., Golasangi Chidanand ,   Post-Graduate Trainee, Dept. Of Orthopaedic Surgery, AGMC & GBPH, Tripura., Kumar Halam Ajoy ,   Post-Graduate Trainee, Dept. Of Orthopaedic Surgery, AGMC & GBPH, Tripura.
Published: March 2023

Introduction: Neglected posterior elbow dislocation is common in developing countries. Various treatment methods have been described. Considering the lack of facilities and cost constraints in developing countries, the treatment options are limited. The aim of the study is to evaluate the functional outcome of neglected posterior elbow dislocation managed surgically by open reduction and internal fixation with trans-olecranon Kirschner wire with or without triceps lengthening. Methods: In a retrospective study from July 2020 to June 2022, 7 patients with neglected posterior elbow dislocation were treated in our hospital with mean follow-up of 11.14 months. The Mayo Elbow Performance Index (MEPI) was used to assess subjective, objective, and functional characteristics before and after operation. Results: The mean age of 7 patients (4-males and 3-females) was 26 years. The most common mode of injury was fall with mean time interval between injury and surgery of 8.14 weeks. The mean duration of surgery was 75.71 minutes. The mean pre-operative elbow flexion was 17.86Âº and post-operative elbow flexion was 92.14Âº. The mean pre-operative elbow PS (pronation-supination) range was 17.14Âº and post-operative elbow PS range was 109.29Âº. The mean pre-operative MEPI was 5 and post-operative MEPI was 77.86. Five patients had satisfactory results (2- Excellent and 3- Good) and 2 patients had unsatisfactory results (1- Fair and 1- Poor). Conclusion: Considering all limitations in developing countries, open reduction with or without triceps lengthening followed by post-operative range of motion exercises is still the mainstay treatment to gain a functional arc of motion in the management of neglected posterior elbow dislocation.
EXPLORING THE LINK BETWEEN KANYASHREE PRAKALPA AND GIRL CHILD EDUCATION
Authors:   Student, J,D.Birla Institute., Banerjee Sreshtha , Mukherjee Promita ,   Assistant Professor, J.D.Birla Institute.
Published: March 2023

In the recent times, to stimulate the educational potential as well as to stop the early marriages of female child, West Bengal Government, with the expertise of Ministry of Department of Women development and Social Welfare (DWD&SD) curated a cash incentive scheme called Kanyashree Prakalpa, launched in the year of 2013, dated 8th April. The main objective of the scheme was to promote higher education as well as stop child marriage, which will showcase a decrease in the mortality rate of both mother and child.The implementation of Kanyashree Prakalpa was done and became a success, but what is the present scenario regarding the scheme?Thepaper specifically caters the educational aspect of Kanyashree Prakalpa and from the results it was determined whether the scheme has served its purpose in the current setting.The findings of this study suggest that Kanyashree had positive impact on female admission rate in rural area and dropout rate in both rural and urban areas.
PREVALENCE OF PHLEBITIS AMONG PATIENTS RECEIVING PERIPHERAL INTRAVENOUS THERAPY IN A TERTIARY CARE HOSPITAL IN INDIA
Authors:   Nursing Supervisor, Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India., M. Dhatchayani , Jude Sharon ,   Registered Nurse- Pain management, Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India., George Alphonsa ,   Nurse Educator, Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India., C. Hemakumari ,   Infection Control Nurse, Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India., Mitchel Domingo Sunita ,   GM Nursing (Former), Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India., Sharma Rohini ,   Vice Principal, Apollo School of Nursing, Sarita Vihar, New Delhi., Das Rachana ,   Assistant Manager, Department of Nursing, Apollo Hospitals Bannerghatta Road, Bengaluru, India.
Published: March 2023

Background: Phlebitis is a common complication associated with the use of peripheral intravenous catheters. Main uses of a peripheral intravenous catheter are infusions, blood sampling, administration of parenteral medications and blood products. It is one of the commonly performed procedure in hospital. Almost all of hospital admissions lead to intravenous catheter placement. Aim:To assess the prevalence of phlebitis among patients on peripheral intravenous catheter and identify predisposing factors of phlebitis in patients. Methodology: 398adult patients in wards, with Peripheral intravenous catheter (PIVC) were included in the study during a period of 4 months. Catheter insertion site of these patients were observed for signs of phlebitis using Visual Infusion Phlebitis scale, until discharge or until the resite of next catheter. The data collection and analysis included patient demographic details and data related to catheter (including number of attempts during insertion, experience of staff performing the cannulation, reasons for removal etc.), as well as the data on the type of administered medications and intravenous therapy. Results:A total of 398 patients were enrolled, among which 228 were males and 170 were females. A total of 192 patients (48.24%) showed one or other early signs of phlebitis. Among these 192 patients with early signs of phlebitis, 128 patients (66.67%) had score 1 in VIP scale while 64 patients (20.47%) had score 2 and 3.Phlebitis was found to be associated with mobility status of the patients (<0.001). Conclusion:This study showed a high prevalence of phlebitis among inpatients in wards. However, most of these cases were mild Grade 1 phlebitis.Its crucial to train and upskill staffs on PIVC insertion and monitoring to ensure proper placement and assessment. Daily assessment of insertion site and need for PIVC and patient awareness on PIVC maintenance is crucial in prevention of phlebitis.
EVALUATION OF THE KNOWLEDGE AND CONSUMPTION OF FOOD SUPPLEMENTS IN SIX (06) COMMUNES OF THE DISTRICT OF ABIDJAN: THE CASE OF SPIRULINA (ARTHROSPIRA PLATENSIS) AND MORINGA (MORINGA OLEIFERA)
Authors:   Institut Pasteur of Cote dIvoire, 01 BP 490 Abidjan 01, Cote dIvoire., Karidja Ouattara Yakoura ,   Departement of Food Sciences and Technologies (STA), Laboratory of Microbiology and Biotechnology, Nangui Abrogoua University, 02 BP 801 Abidjan 02, Cote dIvoire., Julien Coulibaly Kalpy ,   Institut Pasteur of Cote dIvoire, 01 BP 490 Abidjan 01, Cote dIvoire., Ibrahima Coulibaly Zanakoungo ,   Institut Pasteur of Cote dIvoire, 01 BP 490 Abidjan 01, Cote dIvoire., Yatanan Casimir Ble ,   Department of Agronomic Forest and Environmental Engineering, University of Man, BP 20 Man, Cote dIvoire., Ndri Sabine Vakou ,   Institut Pasteur of Cote dIvoire, 01 BP 490 Abidjan 01, Cote dIvoire., Offianan Toure Andre ,   Institut Pasteur of Cote dIvoire, 01 BP 490 Abidjan 01, Cote dIvoire., Dadie Adjehi ,   Departement of Food Sciences and Technologies (STA), Laboratory of Microbiology and Biotechnology, Nangui Abrogoua University, 02 BP 801 Abidjan 02, Cote dIvoire.
Published: March 2023

Food supplements are playing an increasingly important role in ourdiet. Moringa and Spirulina are twofoodsupplementsproduced and marketed in the Ivory Coast. However, verylittle data exists on the level of consumption of thesefoodsupplements. The objective of thisstudywas to assess the level of knowledge and consumption of thesetwoproducts in six communes of the Abidjan district. To achievethis, a questionnaire wasadministered to 446 households. The studyrevealedthat 100% of the householdssurveyedknew about Moringa, while 43.5% knew about Spirulina.71.75%ofthe householdssurveyedhadalreadyconsumedtheseproducts. For 90.4% of the householdssurveyed, theseproducts are consumed in powderform. And the reasons for consumptionwere due in 72.84% of cases to healthproblems. However, 45.40% of household respondentssaidtheyhadexperienceddiscomfort as a result of consuming Moringa. This studyreveals the effectiveness of the dietary use of Moringa and/or Spirulina in the householdssurveyed. However, the mention of undesirableeffectsreportedshouldbe the subject of furtherstudy on the healthquality of thesesupplements, which are becomingincreasinglypopular.
ETHNOVETERINARY MEDICINAL PLANTS USED FOR ANIMAL THERAPY BY THE TRIBALS OF AMRABAD TIGER RESERVE FOREST OF NAGARKURNOOL DISTRICT, TELANGANA STATE, S. INDIA
Authors:   Palynology and Paleobotany Research Lab, Department of Botany, University College of Science, Saifabad, Osmania University, Hyderabad - 500004., Parameshwari T. , Chaya P. ,   Palynology and Paleobotany Research Lab, Department of Botany, University College of Science, Saifabad, Osmania University, Hyderabad - 500004.
Published: March 2023

Medicinal plants finds a significant role in the livestock health care system for a long period especially in remote areas. On an ongoing work on Ethnoveterinary studies, the present paper deals with the documentation of the medicinal plant species used for the treatment of various veterinary health diseases of the livestock practiced by the indigenous people of the Amrabad Tiger reserve forest of Nagarkurnool district of Telangana state. Periodic field trips, semi structured questionnaires and group discussions were conducted during Jan. 2018-July 2018 to collect the data. A total of 12 medicinal plants referable to 9 families have been recorded with ethnoveterinary uses. These include 6 herbs and 6 tree members. Among the plant families, Solonaceae represented by three genera, Apocynaceae by two, Capparidaceae, Moraceae, Acanthaceae, Lecythidaceae, Asclepiadaceae, Fabaceae, and Rhamnaceae by one genus each. Leaves, bark or whole plant were the consistently used parts. The study highlights that the local people of Amrabad Tiger Reserve forest of Nagarkurnool district holds rich ethnoveterinary knowledge to cure livestock diseases.