bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetism in Heterobimetallic and Heterotrimetallic Chains Based on the Use of [WV(bipy)(CN)6]– as a Metalloligand
Authors: Alexandru Maria‐Gabriela , Visinescu Diana , Shova Sergiu , Andruh Marius , Lloret Francesc , Julve Miguel
Published: December 2017

Two new heterobi‐ and trimetallic chains of formula ∞1[{MnII(pyim)2}{(µ‐NC)2WV(bipy)(CN)4}][WV(bipy)(CN)6] (1) and ∞1[{CuIIMnIIL}{(µ‐NC)3WV(bipy)(CN)3}][WV(bipy)(CN)6]·0.75H2O·2MeCN (2) were obtained by reacting the cyanido‐based AsPh4[W(bipy)(CN)6] heteroleptic complex with the pre‐formed [MnII(pyim)2]2+ (1) and [CuIIMnIIL]2+ (2) complexes [bipy = 2,2′‐bipyridine, pyim = 2‐(1H‐imidazol‐2‐yl)pyridine and H2L = macrocyclic Schiff‐base resulting from the stepwise condensation of 2,6‐diformyl‐p‐cresol with ethylenediamine and diethylenetriamine]. The structure of 1 consists of cationic cyanido‐bridged {MnIIWV} chains, assembled from [WV(bipy)(CN)6]– spacers, each one coordinating in a bis‐monodentate fashion, two [MnII(pyim)2]2+ nodes, and [WV(bipy)(CN)6]– counteranions. Compound 2 comprises a positively charged 1D coordination polymer, built from [WV(bipy)(CN)6]– cyanido metalloligands that act as tris‐monodentate spacers towards [CuIIMnIIL]2+ complexes, the entire assembly being neutralized by [WV(bipy)(CN)6]– anions. Each manganese(II) ion in 1 is six‐coordinate in a somewhat distorted octahedral surrounding. Five‐coordinate copper(II) and seven‐coordinate manganese(II) ions exhibiting distorted square pyramidal and monocapped trigonal prism environments respectively, occur in each {CuIIMnII} node of 2. The magnetic susceptibility of 1 and 2 investigated down to 1.9 K is characteristic of 1D ferrimagnetic behavior with minima in the χMT vs. T plots at 35 (1) and 20 K (2) (χM is the magnetic susceptibility per one MnII plus two WV ions). The magnetic data of 1 in the whole temperature range were analyzed through a model considering SMn = 5/2 as a classical spin and SW = 1/2 as a quantum spin, with two interaction parameters J1 = J(1 – α) and J2 = J(1 + α) {the spin Hamiltonian being defined as H = –JΣiSW,i[(1 + α)SMn,j + (1 – α)SMn,i+1] + Σi(gWSW,i + gMnSMn,i)βH}. The values of the intrachain antiferromagnetic interactions for 1 through this model were –3.0(1) (J1) and –32.0(1) cm–1 (J2). The complexity of the spin topology in 2, a branched chain with four different intrachain antiferromagnetic interactions (double phenoxido bridge between MnII and CuII, two single cyanido bridges between MnII and CuII, and one single cyanido bridge between CuII and WV) precluded any simulation of its magnetic data.
Heterogeneous expression and biological function of SOX18 in osteosaroma
Authors: Zhu Danjie , Yang Di , Li Xiaolin , Feng Fabo
Published: December 2017

Osteosaroma (OS) is a primary bone malignancy and is associated with high morbidity. Sex determining region Y‐box 18 (SOX18) is identified overexpressed in OS. However, the molecular mechanism underlying the biological function of SOX18 in OS is still unclear. The aim of the current study was to determine the SOX18 expression in patients with OS and its effect on tumor cell malignant phenotypes. Our results showed that SOX18 was overexpressed in OS patients from both E‐MEXP‐3628 database and independent samples from our hospital and in OS cell lines. SOX18 silencing significantly induced G0‐G1 phase cell cycle arrest and apoptosis and inhibited U‐2OS cell migration and invasion and cell growth both in vitro and in vivo. However, SOX18 overexpression remarkably promoted 143B cell proliferation, migration and invasion and inhibited cell cycle arrest and apoptosis. The protein expression levels of p53, p21, Bax, Bcl‐2, and Caspase‐3 were also regulated by SOX18. Moreover, SOX18 was found negative correlated with the expression of HERC1, HER2, HERC3, HERC4, HERC5, and HERC6 in OS patients and in OS cells, with the most significant correlation detected in HERC2 expression, which was following found interacted with SOX18 in OS cells. Taken together, our results suggest that SOX18 is overexpressed in OS and plays an important role in proliferation, apoptosis, migration and invasion of OS cells, and may provide a novel and promising thera­peutic strategy for OS.
Mechanistic effects of mesenchymal and hematopoietic stem cells: New therapeutic targets in myocardial infarction
Authors: Shafei Ayman El‐Sayed , Ali Mahmoud A. , Ghanem Hazem G. , Shehata Ahmed I. , Abdelgawad Ahmed A. , Handal Hossam R. , ElSayed Abdelfatah S. , Ashaal Ahmed E. , Ali Mazen M. , El‐Shal Amal S.
Published: December 2017

Myocardial infarction (MI) results in dysfunction and irreversible loss of cardiomyocytes and is of the most serious health threats today. Mesenchymal stem cells (MSCs) and hematopoietic stem cells (HSCs) have been explored as promising cell therapy in MI and regenerative therapy. Recently, reports investigated the potential therapeutic effects of MSCs or HSCs transplantation after MI in numerous experimental and clinical studies; however, their results are controversy and needs more explorations. The current review is an attempt to clarify the therapeutic potentials of MSCs and HSCs in MI therapy, as well as their possible effects; especially the paracrine one and the exosome‐derived stem cell among animal models as well as clinical trials conducted within the last 10 years. In this context, various sources of MSCs and HSCs have been addressed in helping cardiac regeneration by either revitalizing the cardiac stem cells niche or revascularizing the arteries and veins of the heart. In addition, both MSCs and HSCs could produce paracrine mediators and growth factors which led to cardiomyocytes protection, angiogenesis, immunemodulation, antioxidants, anti‐apoptotic, anti‐inflammatory, antifibrotic, as well as increasing cardiac contractility. Recently, microRNAs (miRNAs), post‐transcriptional regulators of gene expression, and long non‐coding RNA (lncRNA), a miRNA sponge, are recent stem cell‐derived mediators can be promising targets of MSCs and HSCs through their paracrine effects. Although MSCs and HSCs have achieved considerable achievements, however, some challenges still remain that need to be overcome in order to establish it as a successful technique. The present review clarified the mechanistic potentials of MSCs and HSCs especially paracrine effects involved in MI including human and animal studies and the challenges challenges regarding type, differentiation, route, and number of injections.
Potential neuroprotective effect of androst‐5‐ene‐3β, 17β‐diol (ADIOL) on the striatum, and substantia nigra in Parkinson's disease rat model
Authors: Salama Rania M. , Tadros Mariane G. , Schaalan Mona F. , Bahaa Nevine , Abdel‐tawab Ahmed M. , Khalifa Amani E.
Published: December 2017

Parkinson's disease (PD) is a progressive neurodegenerative disorder with behavioral and motor abnormalities. Androst‐5‐ene‐3β, 17β‐diol (ADIOL), an estrogen receptor (ER) β agonist, was found to mediate a transrepressive mechanism that selectively modulates the extent of neuroinflammation and, in turn, neurodegeneration. In consensus, ERβ polymorphism was more frequently detected in early‐onset PD patients. Thus, in an approach to elucidate the role of ERβ agonists on PD, our study was designed to investigate the possible neuroprotective effect of ADIOL, in three dose levels (0.35, 3.5, 35 mg/kg/day), against rotenone (ROT)‐induced PD rat model. Amelioration in striatal dopamine (DA), nuclear factor‐kappa B (NF‐κB), and the expression of down‐stream inflammatory mediators, as well as apoptotic markers were observed in the striatum and substantia nigra (SN) upon pre‐treatment with the three doses of ADIOL. Similarly, light microscopy (LM) examination revealed declined degeneration of neurons upon pretreatment with ADIOL. Significant improvement in nigral tyrosine hydroxylase (TH) and reduction of nigral α‐synuclein densities were also detected after ADIOL pre‐treatment with better results frequently achieved with the middle dose (3.5 mg/kg/day). The middle dose of ADIOL showed behavioral improvement, with elevation in the ATP level, which was emphasized by the improvement in mitochondrial integrity observed upon electron microscopy (EM) examination. In conclusion, the present study confirmed for the first time the ability of ADIOL to protect against neuroinflammation and, in turn, neurodegeneration process and motor dysfunction in PD animal model, which was more obviously observed with the middle dose.
Coarse‐grained A‐graft‐B model of poly(lactic acid) for molecular dynamics simulations
Authors: Glagolev Mikhail , Glova Artyom , Mezhenskaia Daria , Falkovich Stanislav , Larin Sergey , Vasilevskaya Valentina , Lyulin Sergey
Published: December 2017

A mesoscopic model of poly(lactic acid) is developed where the polymer is represented as an A‐graft‐B chain with monomer units consisting of two covalently connected beads. A coarse‐graining algorithm is proposed to convert an atomistic model of PLA into a coarse‐grained one. The developed model is based on atomistic simulations of oligolactides to take into account terminal groups correctly. It was used for coarse‐grained simulations of polylactide. Gyration radii and end to end distances of polymer chains as well as the density of the polymer melt are shown to be in a good agreement with those obtained from atomistic simulations. The thermal expansion coefficients of the OLA melts calculated using the coarse‐grained model are in reasonable agreement with those obtained from all‐atom molecular dynamics. The model provides a 17‐fold speedup compared with atomistic calculations. © 2017 Wiley Periodicals, Inc. J. Polym. Sci., Part B: Polym. Phys. 2018, 56, 604–612
Periodic pulsating dynamics of slow–fast delayed systems with a period close to the delay
Authors: KRAVETC P. , RACHINSKII D. , VLADIMIROV A.
Published: December 2017

We consider slow–fast delayed systems and discuss pulsating periodic solutions, which are characterised by specific properties that (a) the period of the periodic solution is close to the delay, and (b) these solutions are formed close to a bifurcation threshold. Such solutions were previously found in models of mode-locked lasers. Through a case study of population models, this work demonstrates the existence of similar solutions for a rather wide class of delayed systems. The periodic dynamics originates from the Hopf bifurcation on the positive equilibrium. We show that the continuous transformation of the periodic orbit to the pulsating regime is simultaneous with multiple secondary almost resonant Hopf bifurcations, which the equilibrium undergoes over a short interval of parameter values. We derive asymptotic approximations for the pulsating periodic solution and consider scaling of the solution and its period with the small parameter that measures the ratio of the time scales. The role of competition for the realisation of the bifurcation scenario is highlighted.
Cognitive processing therapy for post-traumatic stress disorder in a University Counselling Center: an outcome study
Authors: Wilkinson Charity , von Linden Meghan , Wacha-Montes Annmarie , Bryan Craig , O'Leary Katherine
Published: December 2017

More than half of college students endorse experiencing at least one traumatic event. Consistent with other populations, the rate of post-traumatic stress disorder (PTSD) for college students has been reported at around 12%. Despite this, empirically supported treatments for PTSD have not been widely disseminated in University Counselling Centers (UCCs). This study examines outcomes using cognitive processing therapy (CPT) with a sample of n = 26 college students in a UCC setting. This study also examines therapist experience, length of degree and symptom severity on outcome. After completing training, n = 8 therapists completed CPT consultation and certification. Students who participated in individual CPT during this process were administered the PCL-5 and PHQ-9 at weekly sessions. A retrospective chart review was completed. PCL-5 and PHQ-9 scores were separately examined as outcome variables using linear mixed models where session, therapist experience, length of therapist degree, and severity of symptoms were included as fixed effects, and subjects were assumed to have a random effect. Significant reductions in PCL-5 and PHQ-9 scores were observed across treatment. In this sample, 84.6% of students were treatment responders. Results were unchanged when adjusting for therapist level of experience or training. CPT shows strong potential for UCC settings. CPT can be successfully implemented with novice therapists.
Regulatory Chill in a Warming World: The Threat to Climate Policy Posed by Investor-State Dispute Settlement
Authors: Tienhaara Kyla
Published: December 2017

The system of investor-state dispute settlement (ISDS) found in over 3,000 bilateral investment treaties and numerous regional trade agreements has been criticized for interfering with the rights of sovereign states to regulate investment in the public interest, for example, to protect the environment and public health. This article argues that while much of the public debate around ISDS has focused on a small number of cases that have arisen over the regulation of tobacco packaging, there is a far greater threat posed by the potential use of ISDS by the fossil fuel industry to stall action on climate change. It is hypothesized that fossil fuel corporations will emulate a tactic employed by the tobacco industry – that of using ISDS to induce cross-border regulatory chill: the delay in policy uptake in jurisdictions outside the jurisdiction in which the ISDS claim is brought. Importantly, fossil fuel corporations do not have to win any ISDS cases for this strategy to be effective; they only have to be willing to launch them. The article concludes with three options to reform trade and investment agreements to better align them with climate change mitigation efforts: (i) exclude ISDS provisions; (ii) prohibit fossil fuel industries from accessing ISDS; or (iii) carve out all government measures taken in pursuit of international obligations (for example, under the Paris Agreement on climate change) from challenge under ISDS.
Moderne Anästhesie
Authors: Czarnetzki Christoph , Rehberg Benno , Walder Bernhard
Published: December 2017

Zusammenfassung. Anhand von drei Beispielen soll in diesem Artikel gezeigt werden, wie die moderne Anästhesie sich von der blossen Bewusstseins- und Schmerzausschaltung hin zu einer Disziplin der perioperativen Medizin gewandelt hat. Am Beispiel der Entwicklung der Muskelrelaxation wird gezeigt, wie die moderne Pharmakologie in der Anästhesie entscheidend zur intra- und postoperativen Patientensicherheit beiträgt. In einem zweiten Beispiel wird anhand der Schmerztherapie demonstriert, dass die perioperative Betreuung durch die Anästhesie zu einer schmerzarmen, sicheren und rascheren Erholung der Patienten postoperativ führt. Das dritte Beispiel zeigt, wie wichtig eine Standardisierung der perioperativen Abläufe einerseits und ein individuelles Patientenmanagement andererseits für die prä-, intra-, und postoperative Betreuung der Patienten ist, und damit eine drastische Reduktion von Komplikationen erreicht werden kann.
Präoperative Untersuchungen und Abklärungen vor elektiven Eingriffen
Authors: Kaufmann Mark , Lampart Andreas
Published: December 2017

Zusammenfassung. Eine duale Risikomatrix basierend auf dem Operationsrisiko einerseits und dem funktionalen Zustand des Patienten gemäss der ASA-Klasse andererseits ermöglicht die Ableitung der sinnvollen Abklärungsuntersuchungen. Für Patienten ohne relevante Komorbidität gibt es keine Evidenz, dass vor kleineren chirurgischen Eingriffen Routineuntersuchungen Outcome-relevant und damit notwendig sind. Anamnese und klinische Untersuchung genügen! Auf das Vorgehen bei Patienten mit pulmonalen, renalen und endokrinen Begleiterkrankungen wird genauer eingegangen.
Strategien zum Umgang mit antithrombotischen Medikamenten im perioperativen Umfeld
Authors: Yurttas Timur , Filipovic Miodrag
Published: December 2017

Zusammenfassung. Patienten, die unter einer gerinnungshemmenden Behandlung stehen und sich einem Eingriff unterziehen müssen, bedürfen einer genauen interdisziplinären Beurteilung, um das Risiko thromboembolischer Ereignisse einerseits und Blutungen andererseits gegeneinander abzuwägen und daraus eine angepasste Strategie abzuleiten. In dieser Arbeit befassen sich die Autoren mit den aktuell eingesetzten antithrombotischen Medikamenten, deren Verwendung im klinischen Alltag, sowie dem Umgang im perioperativen Umfeld.
You Are Right!
Authors: Dittrich Kerstin , Puffe Lydia , Klauer Karl Christoph
Published: December 2017

Abstract. In the social Simon task, two participants perform a spatial compatibility task together, each of them responding to only one stimulus (e.g., one participant reacts to red, the other to green stimuli). Participants show joint spatial compatibility effects (SCEs), that is, they respond faster when their go-stimulus appears on their half of the screen. Effects are absent when the same go/no-go task is performed without a coactor. Joint SCEs were originally explained in terms of shared task representations, but recent research suggests that effects result from spatial response coding: in joint go/no-go tasks, participants perceive themselves as the right/left participant operating a right/left response key. While previous research showed that the spatial alignment of keys and seats influences the effect, the present research demonstrates that merely instructing participants to be the right/left participant operating a right/left response key instead of labeling participants and keys with arbitrary numbers substantially increases joint SCEs.
Roberta Rudnick Receives 2017 Harry H. Hess Medal
Authors:   AGU
Published: December 2017

Roberta Rudnick was awarded the 2017 Harry H. Hess Medal at the American Geophysical Union Fall Meeting Honors Ceremony, held on 13 December 2017 in New Orleans, La. The medal is for “outstanding achievements in research on the constitution and evolution of the Earth and other planets.”
Correction: Corrigendum: Probing the early stages of shock-induced chondritic meteorite formation at the mesoscale
Authors: Rutherford Michael E. , Chapman David J. , Derrick James G. , Patten Jack R. W. , Bland Philip A. , Rack Alexander , Collins Gareth S. , Eakins Daniel E.
Published: December 2017

Scientific Reports 7: Article number: 45206; published online: 30 May 2017; updated: 22 December 2017. This Article contains errors. In the legend of Figure 1, “(a) Spectral flux per bunch through an on-axis 1 mm2 area delivered by Beamline ID19 in the four bunch mode (40 mA storage ring current), including 2.
Erratum: Corrigendum: Vidatox 30 CH has tumor activating effect in hepatocellular carcinoma
Authors: Giovannini Catia , Baglioni Michele , Baron Toaldo Marco , Cescon Matteo , Bolondi Luigi , Gramantieri Laura
Published: December 2017

Scientific Reports 7: Article number: 44685; published online: 21 March 2017; updated: 22 December 2017. The original title of our paper was inaccurate in referring to ‘Venom from Cuban Blue Scorpion’ and did not accurately reflect that we investigated the effects of the commercially-available product Vidatox 30 CH on hepatocellular carcinoma.
Correction: Corrigendum: Scavenger receptor collectin placenta 1 is a novel receptor involved in the uptake of myelin by phagocytes
Authors: Bogie Jeroen F. J. , Mailleux Jo , Wouters Elien , Jorissen Winde , Grajchen Elien , Vanmol Jasmine , Wouters Kristiaan , Hellings Niels , Horssen Jack van , Vanmierlo Tim , Hendriks Jerome J. A.
Published: December 2017

Scientific Reports 7: Article number: 44794; published online: 20 March 2017; updated: 22 December 2017. The original version of this Article contained a typographical error in the spelling of the author Jack van Horssen, which was incorrectly given as Jack Van Horsen. This has now been corrected inthe PDF and HTML versions of the Article, and in the accompanying Supplementary Dataset File.
A nickel-catalyzed anti-carbometallative cyclization of alkyne–azides with organoboronic acids: synthesis of 2,3-diarylquinolines
Authors: Ranjith Kumar Gadi , Kumar Ravi , Rajesh Manda , Sridhar Reddy Maddi
Published: December 2017

An anti-carbonickelative cyclization via reversible alkenylnickel E/Z isomerization of 2-azido phenyl propargyl alcohols with aryl boronic acids is achieved using Ni(acac)2 as the catalyst to access 2,3-diaryl quinolines.
Thermally activated delayed fluorescence of a Zr-based metal–organic framework
Authors: Mieno H. , Kabe R. , Allendorf M. D. , Adachi C.
Published: December 2017

The first metal–organic framework exhibiting thermally activated delayed fluorescence (TADF) was developed.
Asymmetric Total Synthesis of (+)-Coprophilin
Authors: Shiina Isamu , Umezaki Yuma , Murata Takatsugu , Suzuki Kyohei , Tonoi Takayuki
Published: December 2017

In this paper, we report the first total synthesis of (+)-coprophilin, an anticoccidial agent, by constructing the chiral linear precursor via a Mukaiyama–Evans aldol reaction and a stereoselective intramolecular Diels–Alder reaction. The proposed method can be used to provide large amounts of (+)-coprophilin, which exhibits a 3,4,5,6,7-pentasubstituted Δ1,2-octalin core structure.
Mindestmengen - AOK beklagt „Gelegenheits-Chirurgie“ bei Krebs-Operationen
Authors: Kohrs Jens
Published: December 2017

Viele Krebspatienten in Deutschland sind laut AOK unnötigen Risiken ausgesetzt, weil sie sich in Krankenhäusern mit wenig Erfahrung operieren lassen. Zahlreiche Todesfälle seien vermeidbar, sagt der Kassenchef und fordert neue Mindestmengen für komplizierte OPs.
Technologiepartnerschaft - Gemeinsam auf die Reise machen – und nicht nur Kisten kaufen
Authors: König Romy
Published: December 2017

Das Klinikum Braunschweig hat mit Siemens Healthineers einen Vertrag über eine Radiologiepartnerschaft abgeschlossen. Neben strategischen Vorteilen erhofft sich das städtische Haus auch ganz praktische Verbesserungen.
PapalapApp: Wie gut bekommen Sie Familie und Beruf unter einen Hut?
Authors: Heidecke Claus-Dieter
Published: December 2017

An der Unimedizin Greifswald hat sich die Gleichstellungsbeauftragte etwas Besonderes einfallen lassen, um die zumeist männlichen Führungskräfte auf die Probe zu stellen.
cdgw-Zukunftspreis - Der Handschuh mit dem kleinen Extra
Authors: Hissel Yvonne
Published: December 2017

Ein neuartiger medizinischer Handschuh, der durch eine spezielle Lasche die Übertragung von Keimen verringert – das ist die Innovation, für die das junge Aachener Unternehmen IP Gloves GmbH mit dem Zukunftspreis Gesundheitswirtschaft 2017 ausgezeichnet wurde. Rund 100 Mitglieder und Gäste des Clubs der Gesundheitswirtschaft (cdgw) wählten Mitte November in Berlin aus acht Wettbewerbsteilnehmern ihren Sieger aus.
Digitale Gesundheitstechnik - Fachverbände werden immer wichtiger
Authors: Thalmayr Maria
Published: December 2017

Der Präsident des Verbandes der Österreichischen Krankenhaustechniker (ÖVKT) Martin Krammer ist überzeugt: Fachverbände waren nie so wichtig wie gerade jetzt. Um die Vorteile der Digitalisierung auszuschöpfen sowie zunehmend internationale Normen und Gesetze mitzugestalten und optimal umzusetzen, gewinnen Austausch und Gremienarbeit an Bedeutung.
The Neurology of Immune-Mediated Disorders in Women
Authors: Vodopivec Ivana
Published: December 2017

Many neuroinflammatory disorders have a predilection for women; even if there is no female predominance, neuroinflammatory conditions in women pose a management challenge for several reasons. Disease activity of these conditions may change during pregnancy and commonly increases in the postpartum period. Uncontrolled disease activity may affect pregnancy outcomes. Moreover, immunomodulating agents that are used to suppress the disease activity may have a negative impact on fertility, pregnancy, and fetal outcomes, and on infants who are breastfed. Adverse effects of immunosuppressants extend beyond the reproductive issues and may include bone loss, increased risk of cancers, and infectious complications. The successful management of women with these disorders requires that not only practitioners understand and recognize the adverse effects of immunosuppressants, but also seek to prevent adverse outcomes through counseling about contraceptive choices, safety monitoring, risk surveillance, and other strategies.
Combined Volar and Dorsal Approach for Fixation of Comminuted Intra-Articular Distal Radial Fractures
Authors: Smith M. , Johnstone A. , Medlock G.
Published: December 2017

Purpose Multifragmentary intra-articular fractures displaced in multiple planes are a challenge. We use a reproducible technique of fracture and articular reduction using an initial volar approach targeting reduction in the volar lunate facet first with plate and unicortical locking screws. This creates a template for reduction in dorsal fragments through a dorsal approach. Our study investigated the radiological, clinical, and functional outcomes of patients treated with this technique.

Materials and Methods We reviewed the postoperative radiographs and notes of 18 patients that had this method of fixation between the years 2008 and 2015, the mean age being 43. These patients were reviewed functionally on average 2 years and 3 months following their definitive operation.

Results Normal alignment and length to the distal radius were restored with on average a 0.6 mm articular step. The average range of motion was 64% and preservation of grip strength was 71% compared with the uninjured wrist. Functional assessment averages were 29 for both the quick Disabilities of the Arm, Shoulder and Hand (DASH) and for Patient Rated Wrist Evaluation. The modified system of Green and O'Brien had results of good in 10, fair in 7, and poor in 1. With respect to the Gartland and Werley system, three patients had an excellent result, four had a good result, six had a fair result, and five had a poor result. The mean arthritic grading was 1 (grading 0–3) according to Knirk and Jupiter.

Conclusion This reproducible technique provides an option for these devastating fractures providing a functioning wrist with all of the patients returning to their original form of employment.
Schmerzen vor dem Ohr – ist die Ursache immer das Kiefergelenk? Ein Fallbericht
Authors: Hoffmann Marisa , Trouw Michiel
Published: December 2017

Mareike
1
hat Schmerzen im Kiefergelenk. Ihre Vorgeschichte ist komplex. Anhand einer
ausführlichen, strukturierten Untersuchung wird deutlich, dass das Hauptproblem in der kranioneuralen Region liegt. Manuelle Therapie
verändert die Beweglichkeit und den neurologischen Befund, interkraniale Techniken verbessern den Zustand weiter. Neben Hands-on Techniken
sind aktive Übungen und Selbstmanagement ebenso wichtig für den weiteren Erfolg der Therapie.
Behandlungsmöglichkeiten der Kokzygodynie aus Sicht der Manuellen Therapie
Authors: Harlacher A. , Möller D. , von Piekartz H.
Published: December 2017

Schmerzen im Bereich des Steißbeins werden häufig unter dem Begriff
Kokzygodynie
zusammengefasst. Ursache der Beschwerden
können hierbei lokal oder entfernt liegende Strukturen sein. Außerdem gibt es eine Reihe von inneren und psychischen Erkrankungen, die eine
Kokzygodynie vortäuschen können und differenzialdiagnostisch abgeklärt werden müssen.

Dieser Artikel gibt eine Übersicht über Anatomie, Ätiopathologie, Diagnostik, Differenzialdiagnostik und Therapiemöglichkeiten bei
Kokzygodynie. Der Schwerpunkt liegt dabei auf muskuloskeletaler Therapie. Es werden Techniken am Steißbein aus 4 manualtherapeutischen
Konzepten vorgestellt.
Microrobot with passive diamagnetic levitation for microparticle manipulations
Authors: Feng Lin , Zhang Shengyuan , Jiang Yonggang , Zhang Deyuan , Arai Fumihito
Published: December 2017

In this paper, an innovative microrobot with passive diamagnetic levitation is presented. Based on theoretical analysis, finite element method simulation, and experiments, the shape of pyrolytic graphite is redesigned, which improves the stability of passive diamagnetic levitation significantly. Therefore, passive diamagnetic levitation is able to be applied for 3-D control of the microrobot. Compared with the traditional microrobots driven by permanent magnets in a microfluidic chip, the microrobot made of pyrolytic graphite and driven by magnetic force has two advantages, no friction and 3-D control, which is able to expand the scope of the microrobot applications. Finally, the microrobot with passive diamagnetic levitation was demonstrated by being encapsulated in a microfluidic chip for microparticle manipulations.
Coercivity enhancement in PrCu-doped PrCo5 hot deformed magnet
Authors: Zhang D. T. , Jiang W. B. , Zhou D. S. , Lu Q. M. , Liu W. Q. , Yue M.
Published: December 2017

PrCo5 magnet can have excellent magnetic properties and good thermal stability. In this paper, anisotropic nanograin PrCo5 hot deformed magnets with and without PrCu eutectic alloy were prepared by the spark plasma sintering technique. For the 70% hot deformed magnet with 6 wt.% PrCu, the coercivity of the magnet achieves 10.1 kOe, and is increased to be 14.6 kOe after annealed at 550°C, more than twice that of the undoped magnet (6.7 kOe). The nonmagnetic PrCu phase is mainly distributed in the interface of the grains, introducing a demagnetization coupling effect among the hard magnetic grains, resulting in large enhancement of the coercivity.
Role of phase breaking processes on resonant spin transfer torque nano-oscillators
Authors: Sharma Abhishek , Tulapurkar Ashwin A. , Muralidharan Bhaskaran
Published: December 2017

Spin transfer torque nano-oscillators (STNOs) based on magnetoresistance and spin transfer torque effects find potential applications in miniaturized wireless communication devices. Using the non-coherent non-equilibrium Green’s function spin transport formalism self-consistently coupled with the stochastic Landau-Lifshitz-Gilbert-Slonczewski’s equation and the Poisson’s equation, we elucidate the role of elastic phase breaking on the proposed STNO design featuring double barrier resonant tunneling. Demonstrating the immunity of our proposed design, we predict that despite the presence of elastic dephasing, the resonant tunneling magnetic tunnel junction structures facilitate oscillator designs featuring a large enhancement in microwave power up to 8μW delivered to a 50Ω load.
Large power microwave nonlinear effects on multifunction amplifier chip for Ka-band T/R module of phased array radar
Authors: Guo Guo , Gu Ling , Wu Ruowu , Xu Xiong , Zhou Taifu , Niu Xinjian , Liu Yinghui , Wang Hui , Wei Yanyu , Guo Changyong
Published: December 2017

Nonlinear effects of large power millimeter wave on critical chips for the T/R module of phased array radar is experimental studied and analyzed in this paper. A multifunction amplifier chip is selected for our experiments. A solid continuous wave (CW) source and a large power pulsed magnetron are both employed to generate the Ka-band microwave. The input-output characteristics, the degradation and destroy threshold of the chips are obtained through a series of experimental tests. At last, the results are given by figures and analyzed theoretically.
Ontological function annotation of long non-coding RNAs through hierarchical multi-label classification
Authors: Zhang Jingpu , Zhang Zuping , Wang Zixiang , Liu Yuting , Deng Lei
Published: December 2017

Motivation

Long non-coding RNAs (lncRNAs) are an enormous collection of functional non-coding RNAs. Over the past decades, a large number of novel lncRNA genes have been identified. However, most of the lncRNAs remain function uncharacterized at present. Computational approaches provide a new insight to understand the potential functional implications of lncRNAs.

Results

Considering that each lncRNA may have multiple functions and a function may be further specialized into sub-functions, here we describe NeuraNetL2GO, a computational ontological function prediction approach for lncRNAs using hierarchical multi-label classification strategy based on multiple neural networks. The neural networks are incrementally trained level by level, each performing the prediction of gene ontology (GO) terms belonging to a given level. In NeuraNetL2GO, we use topological features of the lncRNA similarity network as the input of the neural networks and employ the output results to annotate the lncRNAs. We show that NeuraNetL2GO achieves the best performance and the overall advantage in maximum F-measure and coverage on the manually annotated lncRNA2GO-55 dataset compared to other state-of-the-art methods.

Availability and implementation

The source code and data are available at http://denglab.org/NeuraNetL2GO/.

Supplementary information

Supplementary data are available at Bioinformatics online.
Cancer therapy-induced cardiomyopathy: can human induced pluripotent stem cell modelling help prevent it?
Authors: Stack Jonathan P , Moslehi Javid , Sayed Nazish , Wu Joseph C
Published: December 2017

Cardiotoxic effects from cancer therapy are a major cause of morbidity during cancer treatment. Unexpected toxicity can occur during treatment and/or after completion of therapy, into the time of cancer survivorship. While older drugs such as anthracyclines have well-known cardiotoxic effects, newer drugs such as tyrosine kinase inhibitors, proteasome inhibitors, and immunotherapies also can cause diverse cardiovascular and metabolic complications. Human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) are increasingly being used as instruments for disease modelling, drug discovery, and mechanistic toxicity studies. Promising results with hiPSC-CM chemotherapy studies are raising hopes for improving cancer therapies through personalized medicine and safer drug development. Here, we review the cardiotoxicity profiles of common chemotherapeutic agents as well as efforts to model them in vitro using hiPSC-CMs.
Implications of late-in-life density-dependent growth for fishery size-at-entry leading to maximum sustainable yield
Authors: van Gemert Rob , Andersen Ken H
Published: December 2017

Currently applied fisheries models and stock assessments rely on the assumption that density-dependent regulation only affects processes early in life, as described by stock–recruitment relationships. However, many fish stocks also experience density-dependent processes late in life, such as density-dependent adult growth. Theoretical studies have found that, for stocks which experience strong late-in-life density dependence, maximum sustainable yield (MSY) is obtained with a small fishery size-at-entry that also targets juveniles. This goes against common fisheries advice, which dictates that primarily adults should be fished. This study aims to examine whether the strength of density-dependent growth in actual fish stocks is sufficiently strong to reduce optimal fishery size-at-entry to below size-at-maturity. A size-structured model is fitted to three stocks that have shown indications of late-in-life density-dependent growth: North Sea plaice (Pleuronectes platessa), Northeast Atlantic (NEA) mackerel (Scomber scombrus), and Baltic sprat (Sprattus sprattus balticus). For all stocks, the model predicts exploitation at MSY with a large size-at-entry into the fishery, indicating that late-in-life density dependence in fish stocks is generally not strong enough to warrant the targeting of juveniles. This result lends credibility to the practise of predominantly targeting adults in spite of the presence of late-in-life density-dependent growth.
Selecting for three copepods—feeding of sprat and herring in the Baltic Sea
Authors: Ojaveer Henn , Lankov Ain , Raid Tiit , Põllumäe Arno , Klais Riina
Published: December 2017

Predator–prey interactions are a primary structuring force in marine foodwebs and they play an important role in the dynamics of both marine fish populations and their prey. We investigated the individual and spatial patterns in the feeding of two dominant zooplanktivorous clupeids—herring Clupea harengus membras and sprat Sprattus sprattus—in the Baltic Sea in summer, by means of a taxonomic analysis of stomach content. Both species consumed predominantly the small-sized copepods (Temora longicornis, Eurytemora affinis, and Acartia spp.). E. affinis and T. longicornis were generally positively selected by both species. Centropages hamatus was selected only by sprat. With the exception of Pleopis/Podon spp. in the case of small sprat, the remaining prey, i.e. the zooplankton taxa that were found in fish stomachs, were consumed at similar proportions as they occurred in zooplankton. Stomach fullness of fish increased with the increasing proportions of prey in the zooplankton community. The share of empty stomachs was lower for sprat, and among smaller fish in both species. Pairwise dietary overlap between fish decreased when zooplankton diversity increased. Dietary overlap was also lowest among the individuals of sprat, probably due to the wider diet spectrum and diversity of stomach content compared to herring. Our results point to high interspecific competition, where sprat seems to be more successful than herring in finding and consuming prey, and therefore may have an advantage over herring when the zooplankton community is dominated by small-sized taxa.
Emerging Adult Development and Substance Use Disorders
Authors: Smith Douglas C. , Dumas Tara M. , Davis Jordan P.
Published: December 2017

Developmental processes influence emerging adults’ substance use. Such processes may occur both before and during the period of emerging adulthood, which lasts roughly from ages 18 to 29. This chapter begins by reviewing the prevalence of risky substance use and substance use disorders among emerging adults as well as the sequelae of such use. After a brief review of Arnett’s theory of emerging adulthood, the chapter provides an updated review of how the dimensions of emerging adulthood (i.e., identity exploration, feeling in between, self-focus, instability, optimism) are associated with substance use. Also reviewed are the additional risk factors for substance use that likely interact with these dimensions.
Adaptation Phase Goal 3
Authors: Eddington Kari M. , Strauman Timothy J. , Vieth Angela Z. , Kolden Gregory G.
Published: December 2017

Chapter 9, which addresses the module 3 goal of the adaptation phase of self-system therapy, focuses on managing perfectionism. Many people with depression have standards that are unrealistically high, and they become very self-critical and fear rejection when extreme standards cannot be met. Perfectionists often are willing to cut others some slack but may be reluctant to lower their own standards. The therapist works with clients to take a realistic view of perfectionistic goals and standards and explore more moderate alternatives. Because perfectionism can be compartmentalized, the first step is to identify the areas in clients’ lives that are affected. Worksheets are provided to encourage careful consideration of the costs and benefits of holding on to personal standards that may be too high.
Overview of Self-System Therapy Strategies
Authors: Eddington Kari M. , Strauman Timothy J. , Vieth Angela Z. , Kolden Gregory G.
Published: December 2017

Chapter 4 introduces the core strategies in self-system therapy (SST) and discusses how SST is similar to and different from other short-term, structured therapies, such as cognitive-behavioral therapy, interpersonal psychotherapy, behavioral activation therapy, and acceptance and commitment therapy. SST focuses on self-regulation as a motivational process and targets how clients go about setting, pursuing, and monitoring important personal goals that are defined in part by discrepancies between self-beliefs and self-guides. SST is a structured clinical intervention based on a self-regulation model of depression and involves three phases of treatment: orientation, exploration, and adaptation. Flexibility within this structure allows therapists to tailor strategies, tactics, and assignments to fit the unique needs of each client.
Setting Up a Cognitive Remediation Program
Authors: Medalia Alice , Herlands Tiffany , Saperstein Alice , Revheim Nadine
Published: December 2017

Chapter 3 provides guidelines on how to set up a Neuropsychological Educational Approach to Remediation (NEAR) program. NEAR programs are intended to be implemented in the context of broader recovery-oriented services to facilitate linking of the specific cognitive skill and support interventions to the individual’s overall rehabilitation goals. Cognitive remediation is used to improve the likelihood that people will experience success and satisfaction in their chosen living, learning, working, and social environments. A cognitive remediation program requires clients, physical space, staff, time, startup money, and the commitment and support of the rehabilitation program and administration. The features of each of these components are detailed, and instructions and forms are provided to guide the implementation process.
Phases of Treatment
Authors: Medalia Alice , Herlands Tiffany , Saperstein Alice , Revheim Nadine
Published: December 2017

Chapter 8 explains how the therapist can best prepare to guide cognitive remediation clients through the beginning, middle, and end phases of treatment. In each phase, the overarching goal of the therapist is to engage clients in the process of learning and create an environment that is conducive to cognitive and personal growth. This is accomplished by tailoring the introduction and progression of cognitive exercises and by employing techniques to motivate clients and meet the evolving learning needs of every individual throughout the course of intervention. When CR is successful, clients gain mastery over cognitive skills and strategies, strengthen their identity as independent learners, and progress toward achieving personal goals for recovery.
Children with Anxiety Problems
Authors: Cobham Vanessa E.
Published: December 2017

Anxiety is one of the most common psychological complaints reported by children and is associated with significant psychosocial and physical health problems, a poor prognosis, and significant economic burden. Anxiety is transmitted within families, with parenting variables implicated in the etiology of childhood anxiety. However, meta-analyses have concluded that the addition of a parent component to child-focused cognitive-behavioral therapy does not enhance children’s outcomes. A much smaller body of work has examined the question from the opposite angle, asking, Is it sufficient to work only with parents of anxious children? This research is reviewed and a new parent-only group cognitive-behavioral therapy intervention (Fear-less Triple P) is introduced.
Supporting Parents of Children with Serious Mental Health Problems
Authors: Burke Kylie
Published: December 2017

Serious mental illness affects between 10% and 20% of children and adolescents, significantly representing the world’s children and adolescents. Parents are a critical protective factor in their child’s treatment and recovery from serious mental illness. They support the child during treatment, manage symptom reduction, maintain treatment gains, and promote their child’s development and well-being. Parenting a child or adolescent with serious mental illness places significant strain and burden on them. This chapter discusses evidence-based parenting interventions (e.g., the Triple P—Positive Parenting Program) within the child and adolescent mental health context and their potential to be flexibly and sustainably incorporated into existing usual treatment services. The need is highlighted for researchers, policy-makers, and service providers to focus on developing child- and family-focused mental health policy and better processes for conducting high-quality research that examines specific and combined contributions of parenting interventions within child and adolescent mental health services.
Applying Positive Parenting Programs with Different Types of Families and Family Members
Authors: Sanders Matthew R.
Published: December 2017

The parenting of children takes place in many different kinds of contexts. To avoid a “one-size-fits-all” approach, evidence-based parenting programs must adapt to and accommodate the diverse needs of families in a community. These needs can change over time in an individual family. This section of the book illustrates the flexibility and robustness of the Triple P system in addressing the needs of different types of families. Individual chapters discuss the application of Triple P to working parents, fathers, grandparents, parents with mental health problems, and parents who have been through separation or divorce. The success of these efforts is related to gaining a clear understanding of the context within which parenting tasks and responsibilities are undertaken.
Using Positive Parenting Programs in Different Delivery Systems
Authors: Sanders Matthew R.
Published: December 2017

A population approach to parenting support uses diverse delivery in person and online delivery contexts to provide parents with access to evidence-based programs. No single discipline, service sector, or mode of delivery should monopolize the provision of evidence-based parenting programs. Many different helping professionals come into contact with parents seeking support for parenting issues. It is particularly important that primary care settings are deployed as destigmatized socially normative points of contact for parents. Pediatricians, general practitioners, and community child health nurses are often approached for parenting advice. Similarly, the early childhood education and child care and school settings are also important contexts for the delivery of preventively focused parenting services and programs. In addition to considering how Triple P has been applied in these contexts, this section considers how evidence-based programs can be delivered in the context of the workplace, following natural disasters, through the media, and via the Internet.
Parenting Support in the Workplace
Authors: Haslam Divna M. , Penman Nicole
Published: December 2017

Demographic changes over the last 40 years means the majority of parents are now employed in some capacity. This chapter outlines some of the challenges parents face in balancing competing work and family demands. The concept of work and family conflict is defined, and the impact of work and family conflict on individuals and families is discussed. A rationale is provided for the provision of parenting support via the workplaces as a means of improving the lives of employees and as a way of increasing population-level access to parenting support. A brief review of the efficacy of workplace parenting support is provided alongside practical examples of how to ensure successful program delivery in an organizational context. The chapter concludes with a discussion about the implications and provides some directions for future research.
Broadcast Media–Based Approaches to Positive Parenting
Authors: Metzler Carol W. , Rusby Julie C.
Published: December 2017

Mass media communication approaches have considerable potential for promoting positive parenting at a population level through their wide reach and powerful messaging. A media strategy can promote engagement in parenting programs, destigmatize parenting assistance, affect community norms, and directly impart parenting information to those who might not otherwise be reached. To reach parents with parenting messages, a broad range of media options can be utilized, including television, radio, audio and video streaming, social media, podcasts, and embedding parenting into news stories. Experimental studies of television, video, and radio programming have shown a strong capacity to engage parents and positive effects on parents’ parenting practices, children’s behavior, and family functioning. Important considerations include developing relationships with media outlets and knowing their requirements and interests, embedding the media strategy in a larger system of supports, and adapting flexibly to new media platforms and formats to stay current in a changing media environment.