bluuebunny/crossref_metadata_2025 huggingface dataset:
Transcriptome-wide association study identiﬁes new susceptibility genes and pathways for spondyloarthritis
Authors: Su Xiaochen , Chen Anfa , Teng Menghao , Lou Xiaoxiao , Zhao Xiaoming , Han Hao , Ma Hongyun , Zhang Yingang
Published: July 2022

Background: Spondyloarthritis (SpA) is a group of multifactorial bone diseases influenced by genetic factors, the environment and lifestyle. However, current studies have found a limited number of SpA-related genes, and the genetic and pathogenic mechanism of SpA is still unclear. Methods: A tissue-specific transcriptome-wide association study (TWAS) of SpA was performed by using genome-wide association study (GWAS, including 3966 SpA patients and 452264 controls) summary data and gene expression weights of whole blood and skeletal muscle. The SpA-associated genes identified by TWAS were further compared with the differentially expressed genes (DEGs) identified in the SpA gene expression profile acquired from the Gene Expression Omnibus database (GEO, GSE58667). Finally, FUMA and Metascape were used to perform functional enrichment and annotation analysis.Results: The TWAS detected 28 significant genes associated with SpA in whole blood and skeletal muscle, such as CTNNAL1 (PSM=0.0304, PWB=0.0096). The gene expression profile of SpA identified 20 candidate genes that overlapped in the TWAS data, such as MCM4 (PTWAS=0.0132, PDEG=0.0275) and KIAA1109 (PTWAS=0.0371, PDEG =0.0467). Enrichment analysis of the genes identified by TWAS identified 93 significant GO terms 33 and KEGG pathways, such as mitochondrion organization (GO:0007005) and axon guidance (hsa04360).Conclusion: We identified multiple candidate genes that were genetically related to SpA. Our study may provide novel clues of the genetic mechanism, diagnosis, and treatment of SpA.
LC-MS and GC-MS -based phytochemical perspectives and antimicrobial effects of Endophytic Fungus Chaetomium ovatoascomatis Isolated from Euphorbia milii
Authors: Shaker Kamel H. , Zohair Moustafa M. , Zaki Amal , Sweelam Heba-tollah M. , Ashour Warda E.
Published: July 2022

Antimicrobial activity of endophytic fungi isolated from Euphorbia milli was evaluated against Gram positive, Gram negative bacteria, unicellular yeast and filamentous fungi. The most active strain was selected and identified morphologically and genetically as Chaetomium ovatoascomatis NRC. The total ethyl acetate extract of C. ovatoascomatis NRC exhibited a significant antimicrobial activity against Gram negative; Escherichia coli, Salmonella enteric and fungi; Aspergillus niger with MIC of 62.5 ug/ml. While n-hexane fraction demonstrated broader activity against Gram positive; Bacillus subtilis, Lactobacillus cereus, Gram negative; Escherichia coli and Salmonella enteric, fungi; Candida albicans and F. solani. Phytochemical analysis of ethyl acetate strain extract was performed by LCMSMS analysis and n-hexane fraction was analyzed by GCMS. LCMSMS determined five major metabolites with potential antimicrobial activities including coumarin glycoside; esculin and flavonoids. GCMS analysis of n-hexane fraction tentatively identified 30 compounds, where 9,12-octadecadienoic acid methyl ester was the major compound.
Missing female births and girls in India
Authors: Echavarri Rebeca
Published: July 2022

A significant portion of the mortality affecting girls could be avoided. They are part of the phenomenon known as missing women. A growing body of literature examines whether the rise of sex-selective abortions leads to a decrease in the number of missing girls, by decreasing postnatal discrimination. The evidence is mixed, and theoretical analysis points to social norms as a mechanism that would limit the possible substitution effects. This paper contributes to the literature by identifying the effects of societal-level sex-selection at birth on household-level postnatal discrimination. To that end, the paper merges information from the latest Indian National Family Health Survey (2016 − 2017) and the most recent census (2011). Excess female mortality in childhood is found to be greater in rural districts and in years in which there is a higher male to female sex ratio at birth. This effect is driven by the mortality outcomes of higher birth order girls who are more likely to belong to families that did not use selective abortions as a control for family sex composition. The paper enriches the discussion on why short-run increases in prenatal discrimination do not always help and may even increase the number of missing young girls.JEL B54, J13, J16
Machine Learning-assisted Single Vessel Analysis of Nanoparticle Permeability in Tumour Vasculatures
Authors: Huang Xinglu , Zhu Mingsheng , Zhuang Jie , Li Zhe , Liu Qiqi , Gao Zhanxia , Midgley Adam , Qi Tianyi , Zhao Rongping , Zhang Zhixuan , Kong Deling , Tian Jie , Yan Xiyun
Published: July 2022

The central dogma of nanoparticle delivery to tumours through enhanced leakiness of vasculatures has become a topic of debate in recent years. To address this problem, we created a single-vessel quantitative analysis method by taking advantage of protein-based nanoprobes and image segmentation-based machine learning technology (Nano-ISML). Using Nano-ISML, we quantified > 50,000 individual blood vessels from 32 tumour models, which revealed highly heterogenous vascular permeability of protein-based nanoparticles in different tumours and blood vessels. There was > 20-fold difference in the percentage of high-permeable vessels in different tumours and > 100-fold penetration ability in vessels with the highest permeability compared to vessels with the lowest permeability. We demonstrated that this phenomenon resulted from diversified vascular penetration mechanisms. Specifically, passive extravasation and trans-endothelial transport were dominant mechanisms for high-permeable and low-permeable tumour vessels, respectively. Furthermore, to exemplify Nano-ISML assisted rational design of desirable nanomedicines, we developed genetically tailored protein nanoparticles that improved trans-endothelial transport in low-permeable tumours. Our study delineates the heterogeneity of tumour vascular permeability and defines a direction for rational design of the next generation anti-cancer nanomedicines.
Electrolytic Oxidation of Cyanide on Bare and Manganese Dioxide Coated 304 Stainless Steel Electrodes
Authors: Schmidt Jacob , Guerra Eduard , Shepherd Jeffrey L.
Published: July 2022

Bare and manganese dioxide coated ANSI-304 stainless steel anodes were evaluated for use in electrolytic cyanide waste effluent treatment using bicarbonate buffered electrolytes. Cyclic voltammetry of 10 mM carbonate pH 10 buffered electrolytes showed evidence of mass transfer limited cyanide oxidation just prior to the onset of oxygen gas evolution for both electrode types, and a reaction mechanism in which cyanide is oxidized via reaction with hydroxyl radical containing higher oxidation state species on electrode surfaces is proposed. The results of galvanostatic experiments, conducted in the same base electrolyte with addition of 250 mg L-1 cyanide at a current density of 2 mA cm-2, were fit to a pseudo-first order model of mass transfer limited cyanide oxidation with little difference in cyanide oxidation performance between bare steel and the MnO2 coated electrodes. However, addition of 10 mg L-1 of dissolved copper to the electrolyte was found to enhance the kinetics of cyanide oxidation when employing bare stainless steel electrodes, but had no appreciable effect on cyanide oxidation performance for cells employing manganese dioxide coated electrodes.
Tomato leaf disease identification based on attention mechanism and bilinear pool
Authors: Xiao Jingyao , Fang Chao , Zheng Xiaogang , Liu Jue
Published: July 2022

Aiming at the low recognition rate of current crop diseases by convolutional neural network, we propose the network In-SE-Bilinear model to recognize the tomato leaf diseases. In order to reduce the original number of network layers, GoogLeNet network is used as a back-bone. In the process of feature extraction, a Squeeze-and-Excitation (SE) block is connected after each Inception block, and a bilinear pooling layer is added before the connection layer, in front of which the convolution is used to reduce high-dimensional feature information. It is found that the accuracy rate is about 97% for identifying 16 disease classes, which is significantly better than the traditional convolutional neural network, and superior to Inception model, SE model, and bilinear model. Further, some evaluation indicators are calculated by the confusion matrix using test data set, and the results show that the specificity, recall rate and MIoU are 92.52%, 92.44% and 92.55%, respectively. The In-SE-Bilinear method can effectively improve the ability to recognize and classify tomato diseases.
Integrative bioinformatics analysis of miRNA and mRNA expression profiles identified some potential biomarkers for breast cancer
Authors: Rezaeijo Seyed Masoud , Goharifar Naieme , Poursheikhani Arash , Rezaie Monireh , Shayankia Ghazal , Heydarheydari Sahel , Saberi Alihossein , Taghizadeh Eskandar
Published: July 2022

Background: Breast cancer is common cause of cancer death among women with a complex and heterogeneous picture in histological, molecular and clinical features. The aim of this study was to identify hub genes and related pathways in breast cancer.Methods: We selected screening methods for differentially expressed mRNAs and miRNAs using expression profile data of Breast cancer from The Cancer Genome Atlas (TCGA). with using some databases for annotation, the functional and pathway enrichment for differential expression genes (DEGs) was performed. We selected genes and miRNAs with differential expression pattern. Then we determined target genes for differential expression miRNAs (DEMIs) and intersection between them was selected as differentially expressed miRNA-target genes for breast cancer. In the next step we constructed miRNA-mRNA regulatory network and protein–protein interaction (PPI) network for more information.Results: Top 10 DEMIs were identified from miRNA profile. Then, we selected 354 gene as target gene for 10 DEMIs. The miRNA-mRNA and PPI network constructed and 10 hub genes and 5 miRNAs were identified that some of them are new for breast cancer. Also, miRNA-target genes with differential expressions in this study were all mainly involved in signaling pathways and developmental process.Conclusion: This study identified some candidate biomarker for breast cancer that they have a potential role in pathways related to breast. These findings can be used for research, early diagnosis and therapeutic goals.
Lived experience and students' understanding of the feeling of discrimination in e-learning education
Authors: Jazi Zahra Hadian , Shahzeydi Amir , Farzi Sedigheh , Babaei Sima , Gheybi Kazzem
Published: July 2022

Background
Virtual and e-learning have taken on a more prominent role since the inception of the coronavirus. One of the disadvantages that are less addressed is the feeling of discrimination in this type of education. So, this study aims to explain nursing students' experiences of educational discrimination in e-learning education.
Methods
This is a qualitative study conducted in the Isfahan nursing and midwifery faculty in Iran in 2021. Thirteen nursing and midwifery students were selected by purposeful sampling method and were interviewed and data were collected through face-to-face and in-depth interviews with semi-structured questions. All interviews were analyzed according to the content analysis method.
Results
The factors that caused the feeling of discrimination in the virtual education were into four major categories: 1 - The nature of virtual education (With two subclasses: 1 — less teacher availability and 2 — reduction interaction between the professor and student); 2 - Factors related to the professor (With five subcategories: 1 - professor's experience, 2 — professor's age, 3 — a type of professor's field of work, 4 — professor's skill in using technology and 5 — insignificance of protest and criticisms); 3 - Factors related to students (With four subcategories: 1 - Student gender, 2 - Student field of study, 3 - Student economic problems and 4 - Differences in students' ability to use technology) and 4- Inadequate resources (divided into two sub-categories: 1- Inadequate internet and 2- Lack of access to study and library resources)
Conclusions
Nursing educators and professors must be aware of the factors that cause this feeling before starting this type of training, investigate all suitable platforms such as high-speed internet, train educators, professors, and students in using educational applications, etc.
Statin for patients with aneurysmal subarachnoid hemorrhage (aSAH): A systematic review and meta-analysis
Authors: Radwan Ibrahim
Published: July 2022

Background: Aneurysmal subarachnoid haemorrhage (aSAH) is a serious neurological disease and is associated with early and delayed unfavourable consequences. Vasospasm and delayed cerebral ischemia are reasonable for mortality and permanent disability. Using statin therapy may improve neurological outcomes. The aim of this systematic review is to assess the benefits of statin agents in improving the clinical outcomes in patients with aSAH.
Methods: A search was done electronically using a search strategy (December 2021), combing free– text and medical subject heading (MeSH) terms in five databases: Medline, PubMed, Scopus, Web of Science, and the Cochrane library, with no restriction on language or publication date. This study protocol was registered with PROSPERO, number CRD42022296336. Main Results: nine randomized controlled studies (RCTs) are eligible and included in meta– analysis. The meta– analyses show significant effects of the statins by reduction in the incidences of vasospasm, delayed neurological ischemic deficits, and delayed cerebral ischemia. The pooled MH odds ratios were 0.55 (95% CI 0.39– 0.81), 0.71 (95% CI 0.54– 0.92) and 0.7(95% CI 0.53– 0.94), respectively. The poor outcome and mortality are not statistically different between statins and placebo. The pooled MH odds ratios were 0.97 (95% CI 0.77– 1.22) and 0.85 (95% CI 0.57– 1.26). No significant adverse effects were reported. Also, subgrouping shows that early administration of statins (within 48– 72 hours) of aSAH onset has significant benefits by decreasing the incidence rate of vasospasm, DIND, and DCI.
Conclusion: The statin has a beneficial effect and is safe in patients with aSAH to avoid vasospasm and associated neurological deficits.
WITHDRAWN: Heat transfer characteristics of heat-integrated continuous flow reactor systems for hydrogen production
Authors: Chen Junjie
Published: July 2022

To understand and quantify the complex interactions in continuous flow reactor systems, detailed mathematical modeling of the underlying physical phenomena is an ideal tool to describe the multi-physics. Similarly, to control the overall operation of continuous flow reactor systems requires detailed mathematical models. This study relates to a thermochemical process for producing hydrogen by the catalytic endothermic reaction of methanol with steam in heat-integrated continuous flow reactor systems. Computational fluid dynamics simulations are conducted to better understand the consumption, generation, and exchange of thermal energy between endothermic and exothermic processes in the reactor. The objective of this study is to gain insight into the fundamental characteristics of heat transfer in heat-integrated continuous flow reactor systems. Particular emphasis is placed on the dependence of heat transfer characteristics on different design factors in various situations. The results indicate that the reactor design suffers from a fundamental limitation resulting from the flow configuration in which a reacting stream flows parallel to a heat transfer surface through which the majority of heat is transferred perpendicular to the direction of fluid flow. Balancing the heat requirements of an endothermic reaction with heat generated by an exothermic reaction flowing parallel to and on the opposite side of a separating plate is extraordinarily difficult since the endothermic reaction is likely to have a very different dependence upon concentration and temperature than the endothermic reaction. Thermally matching the reactions is still further complicated by the inherent temperature gradients that are present along the flow length of the reaction channel. Finally, the operating temperatures of the two reactions must be similar since the separate streams are separated only by the thin separating and heat transfer plate.
Evaluation of the Current Status of Home Hemodialysis in the Middle East Then Perspectives and Possibilities of Home Hemodialysis in Egypt
Authors: Omar Ibrahim Al-Sayed Ibrahim
Published: July 2022

Background
Over the last several years, some forms of home hemodialysis are available in some countries in the Middle East especially UAE, Kuwait and Saudi Arabia. Very little data are available regarding the overall outcome, morbidities, and mortalities in this selected group of patients treated with this modality.
Aim of the Work:
This study was done to evaluate the current status of home hemodialysis in the Middle East, then the perspectives of managing it in Egypt.
Patients and Methods:
It included 2 parts (a retrospective and a prospective). The study included 131 patients; either had been maintained on home hemodialysis during the last 5 years or maintained on home hemodialysis during the period from March 2019 to march 2020.
Results
The mean URR% was low in most patients, especially those of the retrospective part (56% versus 63%). Also, the mean KT/V was (1.1 versus 1.18). The 1st year mortality was significantly high in all patients; 36%. However, it was significantly higher in patients of the retrospective part (40.7% versu 28%). Some mortality predictors were unmasked with either with a + ve correlation or a –ve correlation.
Conclusion
In the Middle East, home HD was chosen to manage only a highly compromised group of ESRD patients with strict criteria as patients who are bed-ridden, wheel-chair-bound, demented or having CVA, amputations or non-union fractures …… etc, and having a great difficulty to get in-center HD. It is a benign mode of HD with less reported intra-dialytic complications. Excessive UF was better tolerated in patients with volume overload or cardio-renal syndrome with home HD. The loss of residual renal functions in new HD patients, was significantly low. These benefits were related to less dialysate exposure other than the use of ultrapure dialysate. Nevertheless, Home HD is expensive and less efficient for most patients if done thrice weekly.
Responding to anti-Black racism in clinical supervision: using simulated encounters to develop a behavioral typology
Authors: Calhoun Amanda , Martin Andres , Adigun Ayodola , Alleyne Shirley D. , Asuzu Kammarauche , Thompson-Felix Tara , Asnes Andrea , de Carvalho-Filho Marco A. , Benoit Laelia , Genao Inginia
Published: July 2022

Context
Racist interactions in clinical practice remain a pervasive reality for Black healthcare providers. Supervisors charged with the oversight, protection, and support of their racially minoritized trainees are often inconsistent in their approach and have limited guidance to inform their actions.
Methods
We designed an empirical study in which experienced supervisors responded to seven short, videotaped interactions between 1) a simulated participant (SP) and different clinicians-in-training; 2) the trainees and their respective supervisors; and 3) the trainees and their supervisors together with the SP. The clinical exchanges exemplified different types of racist (entrenching) or antiracist (uprooting) behaviors. After viewing each clip, participants shared their reflections before joining together for a structured debriefing. Using a thematic-phenomenological qualitative approach, we analyzed the corpus of free-text entries and debriefing transcripts.
Results
We recruited 52 participants into five two-hour-long sessions. They developed a behavioral typology for supervisors facing anti-Black racial injuries involving learners under their oversight. We organized supervisor behaviors into five interlocking domains, each with a range of possible responses: 1) Gradation: from conciliatory to confrontational; 2) Explicitness: from eliding to naming; 3) Ownership: from individual to shared; 4) Involvement: from deferred (excusing) to cotemporaneous (including); and 5) Stance: from protective to paternalistic.
Conclusion
A behavioral typology can serve as a rubric for supervisors to engage in reflective practice and for medical educators to inform faculty development initiatives to fight anti-Black racism in clinical practice. In addition, the typology can serve as a framework for facilitated discussion among healthcare providers who may have experienced or witnessed anti-Black racist interactions.
Temporal Localized Turing Patterns in Vertical External-Cavity Surface-Emitting Laser
Authors: Bartolo Adrian , Vigne Nathan , Marconi Mathias , Beaudoin Grégoire , Pantzas Konstantinos , Sagnes Isabelle , Huyet Guillaume , Maucher Fabian , Gurevich Svetlana , Javaloyes Julien , Garnache Arnaud , Giudici Massimo
Published: July 2022

Localized structures (LS) in lasers have been actively sought for all-optical information processing. So far, two distinct approaches have been developed for achieving LS: one leading to addressable stationary peaks of light in the transverse section of the resonator, the other leading to addressable mode-locked pulses having a fundamental mode spatial profile. Here we show that temporal localized patterns appear in nearly self-imaging Vertical External-Cavity Surface-Emitting Lasers (VECSELs) with an intracavity saturable absorber. The observed patterns consist of a combination of an axial plane-wave with a set of tilted waves having a hexagonal arrangement in the Fourier space. In the time domain these patterns are individually addressable mode-locked pulses having a duration of about ten picoseconds. The theoretical analysis shows that the emergence of these pulsating patterns is a signature of a Turing instability whose critical wave vector depends on spherical aberrations of the optical elements. Our result shows that large aspect-ratio VECSELs offer unique opportunities for studying spatio-temporal phenomena and it paves the way to the generation of spatio-temporal LS.
Exploring characteristics and severity of road traffic injuries in Lebanon using emergency department hospital-based data: the necessity of an integrated surveillance system
Authors: Youssef Dalal , Salameh Pascale , Ghosn Nada , Abou-Abbas Linda , Salmi Louis-Rachid
Published: July 2022

Background
In Lebanon, there is a scarcity of data related to road traffic injuries (RTIs), and the available one is of poor quality. Thus, a hospital-based RTI surveillance system was launched by the Lebanese ministry of health in 2013 in private and public-run hospitals in the Bekaa governorate.
Objectives:
The present paper aimed to describe the characteristics and the severity of RTIs recorded over two years during the piloting of the hospital-based RTI surveillance system.
Methods:
The data collected round-the-clock from the Emergency department (ED) was used to conduct a retrospective analysis of population-based injuries hospitalized for road traffic crashes (RTC). This collected data from each person injured or killed in an RTC were reported passively by designated focal persons to the epidemiological surveillance program on a weekly basis, using a standardized form. The form included demographic, crash-related variables, body lesions, and vital-sign clinical presentation. Data were coded using the International Classification of Diseases (ICD-10) and entered using Epidata software then transferred to SPSS for analysis. Trauma scores were calculated to rank the severity of injuries.
Results
Over a period of two years extending from 2013 to 2015, a total of 1576 cases of RTIs were reported. The male-to-female ratio was 2.16 and the majority of RTIs (44.4%) was recorded among those aged between 15 to 29 years old. Out of the total, 51.3% of the accidents occurred during the afternoon time and the most injured parts of the body were the head (46%) and the extremities (75%). From 2013 to 2015, a decrease of 0.7% in the revised trauma score (RTS < 4) was recorded. On the contrary, an increase of 3.9% in injury severity score (ISS) that ranged between 15 and 75 was reported. The probability of survival of an injured individual at one month was improved (from 86.1% in 2013 to 94.1% in 2015).
Conclusion
Despite the presence of some limitations, the piloted RTI surveillance system showed its ability to collect accurate data on RTIs.
The rapid change of mental health in college students after on-campus quarantine in Shanghai 2022 Covid lockdown
Authors: Kuang Yifang , Ma Dongni , Lan Zhaohui , Zeng Suhua , Li Yi , Shang Mengnan , Zhang Ru-Yuan , Wang Lihui , Zhao Binglei , Li Weidong
Published: July 2022

Importance: Social isolation during outbreaks of epidemics always challenge psychological resilience profoundly. However, it still remains unclear how students’ mental health would be affected by strict on-campus quarantine, which means students stayed at dormitories or on-campus for quarantine. We analyzed the data from one of the earliest universities releasing strict on-campus quarantine to prevent the Omicron spread-out in Shanghai, to evaluate the time course of the psychological resilience in the influence of an unexpected change in the living space in university students.Objectives：The campus was locked down on 9th March. From 9th to 23rd, all students on campus were asked to stay in their dormitries, and teachers sent food supplies three times a day. From 24th March to early April, students were gradually allowed to enter the campus for necessary activities. We quantify dynamic changes in depression severity during the campus locked down.Method: All participants were undergraduate or graduate students. The survey was released on 5th, April. All survey was dropped a public link on www.wjx.cn and administered from April 5th to 7th, 2022. Following the schedule of quarantine area, we assessed depressive symptoms in SJTU students from Period 1 (two weeks before 9th, March), Period 2 (9th to 23rd, March), and Period 3 (24th March to 5th April). 274 students completed the online survey, and two incomplete data were excluded for further analysis. All these participants aged range from 18 to 25 years old and were quarantined in dormitories since 9th March 2022.Findings:A remarkable increase in depression was observed in university students after stringent quarantine. The portion of students with depression started at 9.1% before quarantine and rapidly increased to 36.1% right after quarantine. No more increase in depressive symptoms was observed with time though quarantine was ongoing, which can be predicted by the food supplement satisfaction and the duration of physical fitness per day. Interestingly, the impact of a sudden change in living space on the psychological resilence was more evident in students who have a romatic relationship than singles.
A Noninvasive Technique for Cerebral Compliance Monitoring in Neurocritical Care
Authors: Brasil Sérgio , Solla Davi Jorge Fontoura , Nogueira Ricardo de Carvalho , Teixeira Manoel Jacobsen , Malbouisson Luiz Marcelo Sá , Paiva Wellingson Silva
Published: July 2022

Background

In neurocritical care, studies have shown that adequate intracranial pressure (ICP) control reduces mortality and increases functionality. Unfortunately, the monitoring ICP through an intracranial catheter as the gold standard currently adopted, is invasive technique and often not available for all patients in need of ICP monitoring. Recently, a device has been developed (B4C), able to obtain recordings of cranial dilatation at each heartbeat and disclose ICP pulses waveforms, as the intracranial compliance (IC) status. However, despite promising results reported in animal and small sample studies, the correlation between this new technique with invasive ICP measurement in particular clinical situations was lacking. The present study aimed to evaluate the use of this noninvasive IC monitoring system in a set of neurocritical care patients, correlating its data with invasive ICP monitoring. Methods: Neurocritical patients under ICP monitoring were consecutively included for the evaluation with B4C sensor concomitantly. ICP values, ICP waveforms, B4C IC waveforms, were correlated. Results: We present results of 22 patients. Traumatic brain injury, subarachnoid hemorrhage, and stroke were among the main causes for ICP monitoring. Pearson’s correlation for B4C parameters such as P2/P1 ratio and time-to-peak disclosed moderate correlation with mean ICP values (0.63 and 0.66 respectively). No reports of adverse events were obtained.

Conclusion

The novel intracranial compliance monitoring technique demonstrated to be safe and correlated with invasive ICP. This discovery may widen the comprehension, coverage and applications of intracranial compliance in critical care.
Approach to estimating the layout of a 4K4 skidder.
Authors: Добрынин Ю.А. , Андронов А.В. , Зверев И.А.
Published: July 2022

В статье предлагается оценивать компоновку трелёвочного колесного трактора коэффициентом неравномерности распределения нагрузок на передние и задние опоры (оси) в процессе его движения по неровностям пути. Его можно использовать и для других транспортных средств различного назначения.

The article proposes to evaluate the layout of a wheeled skidder by the coefficient of uneven distribution of loads on the front and rear supports (axes) in the process of its movement along the uneven track. It can also be used for other vehicles for various purposes.
The Impact of Digitalization on the Transparency of Public Authorities
Authors: Mynenko Serhii , Lyulyov Oleksii
Published: July 2022

Transparency of public power is one of the main aspects of civil society. The actions of public administration bodies must be transparent, open, and ensure citizens’ legitimate rights and interests. Large-scale digitalization of society also affects public authorities, opening up new opportunities for improving the transparency of public administration and creating risks at various levels of public administration. The study is devoted to the issue of transparency of public authorities under the influence of digitalization. The normative legal acts of Ukraine, the Strategy of digital development, scientific achievements of domestic and foreign scientists are analyzed. The main elements of transparency of public authorities are identified: transparency, openness, and publicity. The level of digitalization penetration into the bodies of legislative, executive and judicial branches of power is characterized. The main functions that digitalization can perform in relation to public authorities are identified. The main achievements of Ukraine in terms of the public power digitalization, which has increased its transparency level, are described. They include a network of web portals of legislative, executive and judicial authorities, which provide public information in the form of messages, files, open data sets, photo and video information. Another important achievement is the service of providing services online and the introduction in Ukraine of full-fledged digital documents, which are analogs of physical. The main indicators of digitalization and characteristics of public authorities are identified: Digital Development Level, IMD World Digital Competitiveness Ranking, ICT goods exports, ICT goods imports, ICT service exports, Voice and Accountability, Political Stability and Absence of Violence/Terrorism, Government Effectiveness, Regulatory Quality, Rule of Law, Control of Corruption. A canonical analysis of digitalization impact on the transparency of public authorities quantitatively shows that public authorities are closely linked to digitalization and influenced by it.
Effects of Glyphosate Application on Preharvest Fruit Drop and Yield in ‘Valencia’ Citrus
Authors: Gairhe Biwek , Dittmar Peter , Kadyampakeni Davie , Batuman Ozgur , Alferez Fernando , Kanissery Ramdas
Published: July 2022

The use of glyphosate as a post-emergent weed management tool is crucial in Florida citrus production. However, extensive and nonjudicious application of glyphosate has drawn increasing concerns about its inadvertent effects on citrus, mainly linked to its possible impacts on preharvest fruit drop. Our study investigated the effect of applying glyphosate in the tree rows near the fruit harvesting window on fruit drop and yield in ‘Valencia’ sweet orange. Field trials were conducted at Southwest Florida Research and Education Center, Immokalee, FL. The experiments had a randomized complete block design with four replications. Three different doses of glyphosate within the labeled range of rates in citrus (i.e., low, medium, and high at 0.84, 2.10, and 4.20 kg acid equivalents of glyphosate per hectare, respectively) along with a water control treatment were sprayed in ‘Valencia’ citrus tree rows close to the harvesting period and assessed for their effects on preharvest fruit drop and yield. Our findings show that glyphosate application near the harvesting window may influence the fruit detachment force (FDF) in Valencia citrus; however, no significant effect on increasing fruit drop or reducing yield was observed during this 2-year study.
Effect of the recombinant chymosins of different origins on production process of soft cheese
Authors: Myagkonosov D. S. , Smykov I. T. , Abramov D. V. , Delitskaya I. N. , Krayushkina V. N.
Published: July 2022

The effect of milk-clotting enzymes (MCE) with different milk-clotting activity (MCA) and proteolytic activity (PA) based on recombinant calf chymosins (Chy-max® Extra: MCA=554 IMCU/g; PA=0.71 UA/g), camel (Chymax® M: MCA=904 IMCU/g; PA=0.68 PA units/g) and “modified” chymosin (Chy-max® Supreme: MCA=912 IMCU/g; PA=0.26 PA units/g) on the duration of milk coagulation, the composition of whey and fresh cheeses in the production of soft cheese of the Italian type Crescenza at a dose of MCE equal to 1500, 2500 and 3500 IMCU per 100 kg of milk was studied. With an equal introduction dose, the shortest average duration of curd formation is noted for Chy-max Supreme MCE (15.0–27.5 min), long one — for Chy-max M MCE (17.0–31.0 min), and the longest one — for MCE Chy-max Extra (18.0–35.5 min). There was no statistically significant effect (p<0.05) of the type and dose of MCE on the total duration of cheese processing, as well as on the content of fat, protein and dry matter of whey. The type and dose of MCE had an impact on the properties of fresh cheeses: cheese options produced with the maximum dose of Chy-max Supreme had a statistically significant (p><0.05) higher average dry matter content (49.61%) than cheese options made with minimal doses of MCE (47.64–47.91%).>< 0.05) of the type and dose of MCE on the total duration of cheese processing, as well as on the content of fat, protein and dry matter of whey. The type and dose of MCE had an impact on the properties of fresh cheeses: cheese options produced with the maximum dose of Chy-max Supreme had a statistically significant (p<0.05) higher average dry matter content (49.61%) than cheese options made with minimal doses of MCE (47.64–47.91%).> <0.05) of the type and dose of MCE on the total duration of cheese processing, as well as on the content of fat, protein and dry matter of whey. The type and dose of MCE had an impact on the properties of fresh cheeses: cheese options produced with the maximum dose of Chy-max Supreme had a statistically significant (p<0.05) higher average dry matter content (49.61%) than cheese options made with minimal doses of MCE (47.64–47.91%).><0.05) higher average dry matter content (49.61%) than cheese options made with minimal doses of MCE (47.64–47.91%).
S onu stranu biologizma i kulturalizma
Authors: Veljak Lino
Published: July 2022

Pod biologizmom se ovdje podrazumijeva primjena striktno biologijskih znanstvenih kriterija i pojmova na područja koja nisu obilježena (ili nisu primarno obilježena) dominacijom biologijskih relacija. Prihvaćanje biologističkog determinizma (primjerice u sociobiologijskoj varijanti) nužno bi rezultiralo razumijevanjem kulture kao determinirane zakonomjernostima biologije. Kao antiteza tom redukcionizmu ispostavlja se kulturalizam, tj. naglašavanje primata kulturnih determinanti oblikovanja kulturnih tvorbi i ljudskog svijeta u cjelini. U radu se dokazuje kako takav kulturalizam predstavlja lažnu alternativu biologizmu te se ljudski svijet primjereno može pojmiti samo ako se na adekvatan način uzmu u obzir sve relevantne dimenzije koje ga oblikuju, što pretpostavlja oslobađanje od svih iskušenja redukcionizma.
Bezumlje govora mržnje – biološka i kulturna dimenzija
Authors: Alić Sead
Published: July 2022

Različite su interpretacije govora mržnje. No, svaka od njih govor mržnje promišlja u kontekstu odnosa slobode govora i mogućih nesloboda uvjetovanih pravnim reguliranjem i sankcioniranjem. U ovom se radu želi krenuti od razmatranja mržnje same (dohvaćajući filozofijske dimenzije, društvene kontekste i političke doprinose u razvoju govora mržnje) te je na taj način promatrati u njezinim biološkim i kulturnim dimenzijama. Na konkretnim primjerima govora mržnje želi se pokazati isprepletenost biološkog i misaonog, kulturnog i tjelesnog te ideološkog i emotivnog. Analiza primjera govora mržnje, ostrašćenosti pojedinaca uronjenih u takvu vrstu psihološke i misaone nezrelosti, pokazuje važnost filozofijskih iskoraka u oskudnu stvarnost – iskoraka kojima je cilj o fenomenima davati filozofijski stav, ali i temeljne kriterije po kojima bi se orijentacijski mogla odrediti druga znanstvena istraživanja.
Basic Thoughts of Vietnamese Classic Aesthetics through Vân đài loại ngữ (雲台類語) by Lê Quý Đôn
Authors: Phan Thị Thu Hiền , Nguyễn Ngọc Thơ
Published: July 2022

Ovo istraživanje smjera razjasniti neke značajke tradicionalne vijetnamske estetske misli izražene kroz Vân đài loại ngữ, »enciklopedijsko« djelo Lêa Quýa Đôna (1726. – 1784.) – poznatog vijetnamskog filozofa, pisca i znanstvenika predmodernog doba. Naše je prijašnje istraživače (Vijetnam, Kina) jako zanimao poetski aspekt djela Vân đài loại ngữ. Naš je novi doprinos koristiti misao Lêa Quýa Đôna kao studiju slučaja vijetnamske klasične estetike. Ispitujući književnost (poglavlje 5, »Văn nghệ«), glazbu i kaligrafiju (poglavlje 6, »Âm tự«) u odnosu na Li i Qi filozofiju (poglavlje 1, »Lý khí«) u djelu Vân đài loại ngữ, naše istraživanje razjašnjuje Lê Quý Đônovu književnu i umjetničku koncepciju književne i umjetničke ljepote temeljenu na iskrenosti, prirodnoj jednostavnosti i harmoniji Yin-Yanga. Objašnjavamo temeljne Lê Quý Đônove koncepte uspoređujući ih s odgovarajućim konceptima kineske estetike da bismo istaknuli jedinstvene karakteristike vijetnamske klasične estetike te pružamo dodatni povijesni kontekst.
The Role of Process Ontology in Cybernetics
Authors: Skansi Sandro , Šekrst Kristina
Published: July 2022

Svrha je ovoga rada pokazati ulogu procesne ontologije u kibernetici. Filozofske temelje kibernetike postavio je Norbert Wiener, koji se služio jezikom punim metafora čovjeka-stroja, opisanih u terminima informacija, povratnih informacija i kontrole. Pokazat ćemo da se različita područja znanosti i danas koriste bitno kibernetičkim definicijama, što će nas dovesti do preformulacije takvog jezika s filozofijske točke gledišta: cilj je kibernetike proučavanje procesnih analogija. Koristeći se načelom kompozicije, pokazat ćemo kako kibernetičar može lako argumentirati ontološku istost dvaju procesa. Takav okvir mogao bi dovesti do toga da se kibernetika smatra potpuno utemeljenom filozofijskom teorijom. Kao posljedicu, ističemo da postoji rastuća potreba za kibernetikom jer, zahvaljujući svojoj specifičnoj procesnoj ontologiji, ona pruža teorijski okvir koji ontološki premošćuje dualizme prisutne u cijeloj suvremenoj znanosti.
Jets in Evolving Matter within the Opacity Expansion Approach
Authors: Sadofyev Andrey , Sievert Matthew D. , Vitev Ivan
Published: July 2022

In a recent study [1] we have extended the opacity expansion approach to describe jet-medium interactions including medium motion effects in the context of heavy-ion collisions. We have computed color field of the in-medium sources, including the effects of the transverse field components and the energy transfer between the medium and jet. The corresponding contributions are sub-eikonal in nature, and were previously ignored in the literature. Here we discuss how our approach can be applied to describe the medium motion effects in the context of Deep Inelastic Scattering.
Measurement of Transverse Spin Dependent Azimuthal Correlations of Charged Pion(s) in $p^{\uparrow} p$ Collisions at $\sqrt s = 200$ GeV at STAR
Authors: Pokhrel Babu
Published: July 2022

At the leading twist, the transversity distribution function,
h^{q}_{1}(x)h1q(x),
where xx
is the longitudinal momentum fraction of the proton carried by quark
qq,
encodes the transverse spin structure of the nucleon. Extraction of it
is difficult because of its chiral-odd nature. In transversely polarized
proton-proton collisions (p^\uparrow pp↑p),
h_{1}^{q}(x)h1q(x)
can be coupled with another chiral-odd partner, a spin-dependent
fragmentation function (FF). The resulting asymmetries in hadron(s)
azimuthal correlations directly probe h_{1}^{q}(x)h1q(x).
We report the measurement of correlation asymmetries for charged pion(s)
in p^\uparrow pp↑p,
through the Collins and the Interference FF channel.
The LHCspin project
Authors: Santimaria Marco , Carassiti Vittore , Ciullo Giuseppe , Di Nezza Pasquale , Lenisa Paolo , Mariani Saverio , Pappalardo Luciano L. , Steffens Erhard
Published: July 2022

Broad and unexplored kinematic regions can be accessed at the LHC
with fixed-target pppp,
pApA
and PbAPbA
collisions at \sqrt{s_{NN}}sNN=72-115 GeV. The LHCb detector is a fully-instrumented
forward spectrometer able to run in fixed-target mode, and currently
hosts a target gas cell to take data in the upcoming Run 3. The LHCspin
project aims at extending this physics program to Run 4 and to bring
polarised physics at the LHC. An overview of the physics potential and a
description of the LHCspin experimental setup are presented.
Zero modes and matching for the twist-3 PDFs
Authors: Bhattacharya Shohini , Cichy Krzysztof , Constantinou Martha , Metz Andreas , Scapellato Aurora , Steffens Fernanda
Published: July 2022

The quasi-PDF approach, proposed by X. Ji in 2013, has made it
possible to directly extract light-cone PDFs from lattice QCD. This
approach relies on the extraction of matrix elements of space-like
operators for fast-moving hadrons. Quasi-PDFs can be related to the
light-cone PDFs through a perturbatively calculable matching
coefficient. We explore the formalism of matching, for the very first
time, for the twist-3 PDFs g_{T}(x)gT(x),
e(x)e(x)
and h_{L}(x)hL(x).
In this work, we address the non-trivialities involved in the extraction
of the matching coefficient due to the presence of (singular) zero-mode
contributions.
Twist-3 partonic distributions from lattice QCD
Authors: Bhattacharya Shohini , Cichy Krzysztof , Constantinou Martha , Metz Andreas , Scapellato Aurora , Steffens Fernanda
Published: July 2022

Twist-3 partonic distributions contain important information that
characterizes nucleon’s structure. In this work, we show our lattice
exploration of the twist-3 PDFs g_T(x)gT(x),
and h_L(x)hL(x).
We also present our preliminary results on the twist-3 GPD
\tilde{G}_2(x)G̃2(x).
We use the quasi-distribution approach to connect the lattice-extracted
matrix elements, renormalized in the RI/MOM scheme, to light-cone
distributions, applying the matching procedure that we developed in
parallel. We also calculate the twist-2 counterparts of
g_T(x)gT(x)
and h_L(x)hL(x),
i.e. g_1(x)g1(x),
and h_1(x)h1(x),
and test the Wandzura-Wilczek approximation.
Differential measurements of jet sub-structure observables and their correlation in p+p collisions at √s = 200 GeV in STAR
Authors: Robotkova Monika
Published: July 2022

This analysis extends recent measurements of the jet sub-structure
observables based on the SoftDrop algorithm in
pp+pp
collisions at \sqrt{s}s
= 200 GeV in the STAR experiment. We present fully unfolded
multi-differential measurements of jet sub-structure observables at the
first split and their correlations for jets of different transverse
momenta and radii. We compare our measurements to various Monte Carlo
models.
PineAPPL: NLO EW corrections for PDF processes
Authors: Schwan Christopher
Published: July 2022

Modern parton distribution function (PDF) determinations either neglect higher-order corrections in the electroweak (EW) coupling or implement them approximately for a subset of PDF processes.
We present a new tool, PineAPPL, which supports perturbative correction in arbitrary powers of the EW and strong coupling constant, and stores theoretical predictions independently of the used PDFs in so-called interpolation grids.
These are the foundation of any PDF determination, and will allow us to perform a PDF fit taking into account EW corrections for all processes consistently.
Apart from PDF determinations PineAPPL can also be used in precision phenomenology to study the impact of different choices of PDF sets, without rerunning the time-consuming computation.
As an application of this tool we show Drell-Yan (DY) lepton-pair production were larger effects of NLO EW corrections can be seen that will potentially influence the PDF fit and comment about which observables are particularly suited and NLO EW PDF fit and which are not.
Market Consequences and Real Earnings Management: Empirical Study in Indonesia
Authors: Ramadan Greska Redielano , Alim Mohammad Nizarul , Prasetyono Prasetyono , Sayidah Nur
Published: July 2022

This research examined the consequences of real earnings management. We analyzed real earnings management’s effects on two aspects of investment: capital market and earnings informativeness. We rely on the efficient market hypothesis theorized by Fama (1969)to predict the market and accounting consequences caused by real earnings management. Our population and samples are a non-financial company listed on the Indonesian Stock Exchange during 2013-2017. We conducted event studies that examine cumulative abnormal return and earnings response coefficient two days before and after the financial statement was published. The model results showed that real earnings management has a negative impact on both stock return and the informativeness of earnings. We also found empirical evidence that the capital market could reach an indication of earnings manipulations through real earnings management. Those results give us the insight that the Indonesian capital market level of efficiencies classified into semi-strong form.
Analysis of the Effect of Implementing Seller’s Integrity and Buyer’s Prudence on Fraudulent Acts in E-Commerce in Indonesia
Authors: Rahmi Asri Noer , Syafei Ade Wirman , Pratiwi Silvia Siska , Darmawan Fiona Daffa
Published: July 2022

The aim of this research is to analyze the effect of implementing seller’s integrity and buyer’s prudence on the fraudulent acts in e-commerce in Indonesia. This research needs to be discussed because of the increase of e-commerce usage as a platform to do transactions between sellers and buyers. The used design in this research is quantitative descriptive research with the secondary data type. The sampling technique used is the purposive sampling technique with e-commerce in Indonesia as the population and total of 200 stores as qualified samples. The data analysis method used is the parametric statistic method with multiple linear regression as the hypothesis testing method. This research used SPSS Version 25 software to process the data. The result shows that the seller’s integrity has a negative significance effect on fraudulent act, while the buyer’s prudence has a positive significant effect on fraudulent act.