bluuebunny/crossref_metadata_2025 huggingface dataset:
A Case of Nivolumab-Induced Bullous Pemphigoid: Review of Dermatologic Toxicity Associated with Programmed Cell Death Protein-1/Programmed Death Ligand-1 Inhibitors and Recommendations for Diagnosis and Management
Authors: Lopez Adriana T. , Geskin Larisa
Published: July 2018

Immunotherapy has emerged as a highly effective treatment for numerous cancers. Use of checkpoint inhibitors against various molecules including programmed cell death protein-1 (PD-1), programmed death ligand-1 (PD-L1), and cytotoxic T-lymphocyte-associated protein-4 have become widespread in clinical practice. Compared with conventional chemotherapy, immunotherapy is associated with a unique set of immune reactions known collectively as immune-related adverse events (irAEs). Of known irAEs, cutaneous toxicity is among the most frequently observed in patients treated with immunotherapy. Although often mild, dermatologic toxicity can occasionally be high grade and potentially life-threatening. In this article, we report a case of PD-1 inhibitor-induced bullous pemphigoid—a serious adverse event that has been increasingly observed with use of PD-1/PD-L1 inhibitors. We will also review diagnosis and management of low-grade cutaneous irAEs and bullous disease with checkpoint inhibitors.

Key Points

PD-1/PD-L1 inhibitor-induced bullous pemphigoid (BP) is a rare but potentially serious dermatologic toxicity associated with checkpoint inhibitors In patients with pruritus or rash that is refractory to topical steroids, physicians should have a greater index of suspicion for higher-grade cutaneous immune-related adverse events. There is no standardized treatment algorithm for management of PD-1/PD-L1 inhibitor-induced BP, but patients frequently require topical and systemic steroids.
Methylation-sensitive high-resolution melting assay (MS-HRM) v2
Authors: Wang Juan
Published: July 2018

Background: Aberrant DNA methylation occurs frequently in cancer. The aim of this study was to identify novel methylation markers in lung cancer in Xuanwei, China, through integrated genome-wide DNA methylation and gene expression studies. Methods: Differentially methylated regions (DMRs) and differentially expressed genes (DEGs) were detected on 10 paired lung cancer tissues and noncancerous lung tissues by methylated DNA immunoprecipitation combined with microarray (MeDIP-chip) and gene expression microarray analyses, respectively. Integrated analysis of DMRs and DEGs was performed to screen out candidate methylation-related genes. Both methylation and expression changes of the candidate genes were further validated and analyzed. Results: Compared with normal lung tissues, lung cancer tissues expressed a total of 6,899 DMRs, including 5,788 hypermethylated regions and 1,111 hypomethylated regions. Integrated analysis of DMRs and DEGs identified 45 tumor-specific candidate genes: 38 genes whose DMRs were hypermethylated and expression was downregulated, and 7 genes whose DMRs were hypomethylated and expression was upregulated. The methylation and expression validation results identified 4 candidate genes (STXBP6, BCL6B, FZD10, and HSPB6) that were significantly hypermethylated and downregulated in most of the tumor tissues compared with the noncancerous lung tissues. Conclusions: This integrated analysis of genome-wide DNA methylation and gene expression in lung cancer in Xuanwei revealed several genes regulated by promoter methylation that have not been described in lung cancer before. These results provide new insight into the carcinogenesis of lung cancer in Xuanwei and represent promising new diagnostic and therapeutic targets.
Western blotting v1
Authors: Wang Juan
Published: July 2018

Abstract Background: Aberrant DNA methylation occurs frequently in cancer. The aim of this study was to identify novel methylation markers in lung cancer in Xuanwei, China, through integrated genome-wide DNA methylation and gene expression studies. Methods: Differentially methylated regions (DMRs) and differentially expressed genes (DEGs) were detected on 10 paired lung cancer tissues and noncancerous lung tissues by methylated DNA immunoprecipitation combined with microarray (MeDIP-chip) and gene expression microarray analyses, respectively. Integrated analysis of DMRs and DEGs was performed to screen out candidate methylation-related genes. Both methylation and expression changes of the candidate genes were further validated and analyzed. Results: Compared with normal lung tissues, lung cancer tissues expressed a total of 6,899 DMRs, including 5,788 hypermethylated regions and 1,111 hypomethylated regions. Integrated analysis of DMRs and DEGs identified 45 tumor-specific candidate genes: 38 genes whose DMRs were hypermethylated and expression was downregulated, and 7 genes whose DMRs were hypomethylated and expression was upregulated. The methylation and expression validation results identified 4 candidate genes (STXBP6, BCL6B, FZD10, and HSPB6) that were significantly hypermethylated and downregulated in most of the tumor tissues compared with the noncancerous lung tissues. Conclusions: This integrated analysis of genome-wide DNA methylation and gene expression in lung cancer in Xuanwei revealed several genes regulated by promoter methylation that have not been described in lung cancer before. These results provide new insight into the carcinogenesis of lung cancer in Xuanwei and represent promising new diagnostic and therapeutic targets.
Objetos de aprendizagem e ensino de literatura: inovação ou tradição?
Authors: Fernandes Marly Aparecida
Published: July 2018

RESUMO: Este artigo discute a dimensão pedagógica e as possibilidades de uso significativo de objetos de aprendizagem para ensinar literatura no contexto brasileiro de Ensino Médio. Ele discute algumas perspectivas dos multiletramentos (COPE; KALANTZIS, 2006 [2000]; 2012) para a compreensão dos conteúdos dos objetos de aprendizagem e de modelos (designs) de aprendizagens, além de conceitos dos novos letramentos (LANKSHEAR; KNOBEL, 2011 [2007]) no sentido de se pensar em outras mentalidades e mudanças de posturas para ensinar literatura utilizando esses objetos de aprendizagem. Considera a necessidade de buscar discussões mais consistentes e amplas que objetivem avanços expressivos em relação às propostas de ensino de literatura com o uso de objetos de aprendizagem.

PALAVRAS-CHAVE: objetos de aprendizagem; multiletramentos; novos letramentos.

 

ABSTRACT: This article discusses the pedagogical dimension and the possibilities for a significant use of learning objects for teaching literature in the Brazilian Middle School context. It discusses some multiliteracies perspectives (COPE; KALANTZIS, 2006 [2000]; 2012) for the understanding contents of learning objects as well as learning designs for teaching literature, and new literacies concepts (LANKSHEAR; KNOBEL, 2011 [2007]) are also considered an attempt to understanding new ethos and new mindset for teaching literature using these learning objects. It considers necessary more consistent discussions concerning proposals of teaching literature using learning objects.

KEYWORDS: learning objects; multiliteracies; new literacies.
Prevalence of anemia in children from two rural schools at different altitudes. A transversal study
Authors: Garrido Salazar David Israel , Garrido Salazar Santiago Moisés , Torres Changoluisa Thania , Fuseau-Herrera Michelle , Muyulema Ruiz Christian , Palate Nuñez Patricio , Paul Toapanta Edgar , Gutiérrez Tapia Miguel
Published: July 2018

ANTECEDENTE: La anemia es un problema global de salud pública que afecta frecuentemente a niños. Sin embargo, no hay evidencia conclusiva respecto de la influencia de la altitud en la anemia de los niños andinos.OBJETIVO: Determinar la prevalencia de anemia en niños de dos escuelas rurales ubicadas a diferentes altitudes geográficas en la misma región administrativa.MATERIALES Y MÉTODOS: Estudio transversal y descriptivo efectuado entre los meses de febrero a marzo de 2017, a través de una fuente secundaria, en pacientes de 5 a 15 años. Los grupos de estudio residían, respectivamente, en Añaspamba y Lita, a 3300- 3500 y 680-700 metros sobre el nivel del mar, respectivamente. A todos los sujetos de estudio se les realizó evaluación médica: medidas antropométricas y concentraciones de hemoglobina. La asociación de riesgo se estableció con razón de momios.RESULTADOS: Se analizaron 228 niños; en 27.6% se detectó anemia y en 11.6% en niños de Añaspamba y Lita, respectivamente. Se estableció la asociación de riesgo entre la prevalencia de anemia y residir en la altura (RM 2.92; p < 0.01); además, se evidenció el riesgo de anemia en niños con sobrepeso (RM 2.92; p < 0.01).CONCLUSIÓN: La prevalencia de anemia fue mayor en los niños de la comunidad rural ubicada en las alturas. Para clarificar esta asociación de riesgo será indispensable aumentar el tamaño de muestra.PALABRAS CLAVE: Anemia; niños; altura; población rural.
Discusión de factores pronóstico en dos casos familiares de fiebre manchada de las Montañas Rocosas
Authors: Delgado de la Mora Jesús , Licona Enríquez Jesús David , Candia-Plata María del Carmen , Álvarez Hernández Gerardo
Published: July 2018

INTRODUCCIÓN: La fiebre manchada de las Montañas Rocosas constituye un problema de salud pública en México, pues genera una elevada tasa de mortalidad. La información relacionada con factores pronóstico (estado nutricional, inmunológico e inóculo bacteriano) es escasa al respecto.CASOS CLÍNICOS: Se reporta el caso clínico de dos pacientes (hermanos): un varón de 9 (caso 1) y una niña de 10 años (caso 2), procedentes de una localidad urbana del sur de Sonora, México, sin antecedentes heredofamiliares ni patológicos de relevancia para el padecimiento actual. Su dieta incluía todos los grupos alimenticios, tres veces al día. Refirieron antecedente de contacto con garrapatas, dentro y fuera de su casa, y convivencia con perros ectoparasitados. Ambos iniciaron con similar cuadro clínico (fiebre, malestar general y exantema). Se prescribió doxiciclina con el mismo esquema y día de evolución; sin embargo, uno de los pacientes falleció y el otro mejoró clínicamente, sin secuelas aparentes. De acuerdo con los hallazgos clínicos o pruebas de laboratorio se estableció el diagnóstico de fiebre manchada de las Montañas Rocosas.CONCLUSIONES: La diferencia en el pronóstico de los pacientes con fiebre manchada de las Montañas Rocosas puede relacionarse con el estado nutricional e inmunológico, así como con la magnitud del inóculo. Se requieren investigaciones adicionales para examinar la participación de dichos factores en el pronóstico de pacientes infectados por Rickettsia rickettsii. PALABRAS CLAVES: Rickettsia rickettsii; enfermedades por garrapatas; pronóstico.
Rekursja jako wspólna podstawa procesów umysłowych, komunikacyjnych i językowych
Authors: Filip Anna , Białek Arkadiusz , Białecka-Pikul Marta
Published: July 2018

For nearly twenty years there has been an ongoing debate in international journals concerning the recursiveness of human mental processes. The main instigator of the debate and at the same time the main exponent of the term “recursion” is Noam Chomsky. According to him, recursion is an exclusive property of the syntax of the so-called “internal language of mind” (I-language). This conclusion has been contested by researchers claiming that recursion can also be observed in: communication, theory of mind, the syntax of complementation, or pragmatics. The article presents some arguments in favor of understanding recursion as a common ground of all the above phenomena as long as they are analyzed from a developmental perspective, with the dynamics and sequentiality of the constantly occurring processes and changes taken into account.
Grandparental social support and communication with peers as predictores of resilience in adolescents from single-mother families
Authors: Napora Elżbieta
Published: July 2018

In the research paradigm focused on the stress-loaded functioning of single-mother families it has been observed that the efficiency of coping with stress depends on many factors, among which social support is one of the most important. Research results show that a higher level of social support is usually associated with more positive indicators of the functioning of an individual. On the basis of this assumption it was expected that social support provided by grandparents would be a significant predictor of mental resilience in adolescent grandchildren from single-mother families – also in conditions differentiated by household type: living with or without grandparents. Studies performed on a sample of 278 adolescents with the Berlin Social Support Scales (BSSS), the Adolescent–Peer Communication Scale, and the Resilience Measurement Scale (SPP-18) have shown that grandparental social support is not the only predictor of adolescents’ functioning.
Polska adaptacja Kwestionariusza Dobrostanu (Psychological Well-Being Scales) Caroll Ryff
Authors: Karaś Dominika , Cieciuch Jan
Published: July 2018

The Psychological Well-Being Scales (PWBS) is a questionnaire designed by Ryff (1989) to mea-sure six dimensions of eudaimonic well-being: self-acceptance, positive relations with others, autonomy, environmental mastery, purpose in life, and personal growth. Translated into several dozen languages, this questionnaire is a commonly used instrument for measuring well-being. The article presents the effects of work on the Polish adaptation of two versions of the PWBS: full (84-item) and short (18-item), conducted as a series of four studies with a total sample of 2,035 participants aged 13 to 78.The results confirmed the reliability of the full version of the PWBS and the six-factor structure of well-being. They also confirmed the criterion validity of the questionnaire, reflected in correlations with validation instruments.
Kwestionariusz Zaangażowania w Diałania Znaczące (KZDZ) B. Goldberg, E. S. Brintnell i J. Goldberga. Adaptacja Polska
Authors: Bożek Agnieszka , Tokarz Aleksandra
Published: July 2018

This study aimed to determine the psychometric properties of the Polish version of the Engagement in Meaningful Activities Survey (EMAS; B. Goldberg, Brintnell, & J. Goldberg), which measures engagement in meaningful activities, understood as activities that serve a purpose significant from a personal or cultural perspective. We present definitions of key concepts, previous research related to the survey, and preliminary research on the Polish version of the survey. The study was conducted on a sample of 237 individuals: employees of cultural institutions, care associations, and corporations as well as teachers working in special schools and high schools. The results indicate a high reliability of the tool (Cronbach’s α = .88). They also reveal relations between engagement in meaningful activities and variables such as meaningfulness of work (r = .65) and job satisfaction (r = .65), and differences across professions in the level of engagement in meaningful activities.
A Relation Between the Flow Density and Flame Length in the Work Space of the Bath Smelting Furnace
Authors: Shvydkii V , Lavrov V , Glukhov I , Ivanova M
Published: July 2018

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Mathematical Model of Heat Exchange and Approximate Methods of Solution of Radiation Transfer Equation in the Melting Furnace Tank
Authors: Shvydkii V , Kiselev E , Dudko V , Solnceva E
Published: July 2018

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Increasing Energy Efficiency of Electric Arc Foundry Furnaces
Authors: Timoshenko S , Gybinskyi M , Yaroshenko Yu , Vvedenska T
Published: July 2018

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Use of Non-distractive Testing AU-E Technology to Evaluate Hearth Conditions at CherMK–SEVERSTAL
Authors: Vinogradov E , Karimov M , Gordon Y , Sadri A , Spirin N
Published: July 2018

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Manganese Ore Thermal Treatment Prior to Smelting
Authors: Gordon Y , Nell J , Yaroshenko Y
Published: July 2018

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Methodology for Cokemaking Technology Selection
Authors: Gordon Y , Brown R , Busser J , Cameron I , Freislich M
Published: July 2018

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Structure of the Optimal Management System for Raw Materials, Fuel and Energy Resources in Blast-furnace Production
Authors: Spirin N , Onorin O , Gurin I , Lavrov V , Shchipanov K
Published: July 2018

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Technical Upgrading and Thermal Performance of Heating Furnace of the Pipe Rolling Workshop
Authors: Shchukina N , Loshkarev N , Lavrov V , Spirin N
Published: July 2018

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Mathematical Model of Heat Exchange of a Plasma Furnace
Authors: Devyatykh E A , Devyatykh T O , Boyarsky A N
Published: July 2018

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Iron Ore Dephosphorization of Gara Djebilet Deposit By Hydrometallurgical Method
Authors: Zajnullin L , Karelin V , Epishin A , Kai C , Malikbaev B
Published: July 2018

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Adaptation of Radiative Properties of the End Products of Fuels Combustion within the Temperature Range of 1,000…2,000 K
Authors: Toropov E V , Lymbina L E , Yaroshenko Yu G
Published: July 2018

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Modeling of Gravitational Separation By the Method of Smoothed Particles Hydrodynamics (SPH)
Authors: Tsymbal V P , Sechenov P A , Olennikov A A
Published: July 2018

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Study of Heat Exchange Processes During Roasting of Iron-ore Pellets
Authors: Yur’ev B , Dudko V
Published: July 2018

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Mathematical Modeling of Determining the Composition of the Charge in the Cross Section of the Blast Furnace
Authors: Zelepukin A , Pykhteeva K , Zagainov S , Tleugabulov B
Published: July 2018

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Development of Measures to Improve the Efficiency of Using Pulverized Coal in Blast Furnace Smelting
Authors: Polovets M , Mironov K , Zagainov S , Tleugabulov B
Published: July 2018

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BAT According to Climatic Neutrality of Production of Steel Products
Authors: Lisienko V G , Shchelokov Ya M , Chesnokov Yu N , Lapteva A V
Published: July 2018

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Mathematical Model of Metal Heating in the Continuous Walking Beam Reheating Furnace
Authors: Loshkarev N B , Noskov V А , Druyhinin G М
Published: July 2018

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Influence of Silicon on Thermal Conductivity at Room Temperature of Al–Si–Fe Alloys
Authors: Zhilin A S , Jianguo L , Yalunina V R , Varlamenko D S , Bykov V A , Derevjankin E V
Published: July 2018

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Influence of Silicon on Temperature Dependence of Thermal Conductivity of Al–Si–Fe Alloys
Authors: Zhilin A S , Jianguo L , Yalunina V R , Tokarev V V , Bykov V A , Shveikin V P
Published: July 2018

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STUDY OF PSYCHOMODULATING PROPERTIES OF ASTRAGALUS VULPINUS WILLD EXTRACT AGAINST THE BACKGROUND OF INFORMATIONAL OVERLOAD
Authors: Samotrueva M. A. , Sergalieva M. U.
Published: July 2018

One of the main tasks of modern pharmacology is the development of new methods for correcting various stress-induced states. An essential role in solving this problem can be played by herbal medicinal products. A special interest is represented by Astragalus vulpinus Willd - a plant of a large Astragalus genus of the legume family (Fabaceae),growing in the Astrakhan Region. The aim of the study is to investigate the effect of the Astragalus vulpinus Willd extract on the psychoemotional state of animals against the background of informational overload (IО). Materials and methods. The experiment was performed on nonlinear male rats. All the manipulations with the animals were carried out according to the rules and principles of work with laboratory animals. The animals were divided into groups: Group 1 - control rats; Group 2 – the animals exposed to IО for 20 days; Group 3 – the animals treated with intragastric liquid extract of Astragalus vulpinus Willd in the dose of 50 mg / kg /a day for 14 days and exposed to IО;Group 4 – the animals treated with the comparative drug of Phenibut in the dose of 25 mg / kg for 14 days against the background of informational overload. The IO model was a multi-alternative labyrinth in which food-producing skills were formed. The psychoemotional state of rats was studied in the “Suok-test” (ST), which is a complex of several classical behavioral models. Results and discussion. The study of laboratory animals’ behavior in the “Suok-test” against the background of informational overload showed the formation of the state of increased anxiety, which was manifested by a decrease in the motor and research activity of white rats. It was established that the Astragalus vulpinus Willd extract has an anxiolytic and antidepressant effect, eliminating manifestations of an anxiety-depressive state developing against the background of informational overload. Conclusion. Estimating the influence of the Astragalus vulpinus Willd extract in comparison with the activity of Phenibutum, it can be concluded that the investigated drugs eliminate the changes in the psychoemotional state of the anxiety-depressive character, demonstrating a practically comparable anxiolytic and antidepressant effect.
TO THE JUBILEE OF PROFESSOR STEPANOVA ELEONORA FEDOROVNA
Authors: Kompantsev D. V. , Kishchenko V. M. , Veselova D. V. , Koryanova K. N.
Published: July 2018

The article is devoted to the anniversary of Professor Eleonora Fedorovna Stepanova – a bright representative of the Russian intelligentsia: a talented lecturer, an inventor, an author of numerous books, an internationally recognized scholar!
La régénération de la forêt tropicale dense dans l'Ouest Africain
Authors: Taylor C.J.
Published: July 2018

Aucun résumé disponible en français.
Analisis Keterampilan Dasar Mengajar Mahasiswa Pada Mata Kuliah Praktek Proses Pembelajaran Biologi
Authors: Dewi Maria Paulin Sari
Published: July 2018

As a prospective teacher, students need to be trained in basic teaching skills before doing Field Experience Practice (PPL). Therefore, it is necessary to conduct research on the level of mastery of basic skills of teaching students. The purpose of this study is to know the basic skills of teaching students, the subjects of Biology Learning Process Practice, Biology Education Study Program, Teacher Training and Education Faculty, Widya Mandira Catholic University, Academic Year 2016/2017. This research is a quantitative descriptive research. The instrument used is the basic teaching skill assessment instrument. Data were collected by observation method and analyzed by descriptive quantitative. The results showed that the average ability to open the learning and attitude in the learning process is very good, with the value of each 3,625 and 3,675; Mastery of teaching materials and learning process is quite good with the value of each 3,475 and 3,575. While the evaluation aspect is quite good with the value of 3,5375 and the ability to close learning is good with a value of 3.4.
Isolasi dan Identifikasi Kapang Pelarut Fosfat dari Fosfat Guano Gua Pawon
Authors: Hafsari Anggita Rahmi
Published: July 2018

The purpose of this study was to isolate and identify phosphate solubilizing Fungi from phosphate guano in Pawon Cave, Karst area, Citatah, West Java. The research design was descriptive. The data obtained were presented descriptively based on macroscopic and microscopic morphological characteristics and the result of qualitative phosphate capability screening on pikovskaya medium. The results showed that there were five isolates in the phosphate guano in Pawon Cave. Karst area, which were Penicillium sp. PF1, Aspergillus sp. PF2, Aspergillus sp. PF3, Mycelia sterilia, and Mucor sp. Based on the screening test, there were two isolates which could solubilize the phosphate, Aspergillus sp. PF3 and Mucor sp.
Optimasi Sumber Karbon Dan Kondisi Fermentasi Produksi Selulosa oleh Strain Bakteri Acetobacter lovaniensis (MGA 6, SLK 1)
Authors: Umami Risa
Published: July 2018

Dalam upaya memperoleh sumber karbon dan kondisi fermentasi selulosa yang paling sesuai oleh strain Acetobacter lovaniensis (MGA 6 dan SLK 1) dilakukan optimasi berbagai faktor fermentasi dengan metode statis. Optimasi sumber karbon dilakukan dengan berbagai cairan buah (nanas, mangga, jeruk, dan pepaya). Berdasarkan sumber karbon dan strain terbaik, selanjutnya dilakukan optimasi kondisi fermentasi yang meliputi konsentrasi sumber karbon, volume inokulum, pH, dan temperatur inkubasi. Penentuan produktivitas selulosa dilakukan pada kondisi optimum dan ditentukan dengan nilai yield. Hasil penelitian menunjukkan bahwa sumber karbon terbaik yaitu cairan buah nanas untuk strain MGA 6. Sumber karbon berupa cairan buah nanas dengan kondisi fermentasi yang optimum yaitu konsentrasi sumber karbon dengan perbandingan buah:air adalah 1:11/2, volume inokulum 10 ml, pH medium 6, dan pada temperatur inkubasi 30oC. Produktivitas selulosa dengan sumber karbon berupa cairan buah nanas sebesar 4,41%.
Uji Viabilitas Virus Dengue Serotipe 3 pada Beberapa Galur Sel (Cell-Line)
Authors: Supardan Dadan , Widada Jaka , Wibawa Tri , Wijayanti Nastiti
Published: July 2018

Infeksi virus dengue (DENV) merupakan infeksi yang menjadi salah satu masalah kesehatan utama di dunia dan salah satu infeksi yang sangat berbahaya terutama dinegara tropis seperti Indonesia.Infeksi dengue disebabkan oleh 4 serotipe virus dengue (DENV-1, DENV-2, DENV-3, dan DENV-4). Virus dengue serotipe 3 (DENV-3) merupakan serotipe dengan karakteristik lebih virulen. Sampai saat ini belum tersedia vaksin dan obat untuk pencegahan dan pengobatan infeksi virus dengue, sehingga penelitian penemuan obat demam berdarah sangat penting dilakukan, akan tetapi pengujian virus dengue pada kultur sel atau cell-line masih banyak mengalami kendala. Salah satu kendala yang sering dijumpai peneliti dalam pengujian senyawa tertentu terhadap virus dengue yaitu virus tersebut tidak mampu berkembang secara optimal pada beberapa jenis kulturcell-line, sehingga dilakukan pengujian untuk mengetahui viabilitas virus dengue pada beberapa kultur cell-line. Penelitian ini bertujuan untuk mengetahui kulturcell line yang paling cocok digunakan untuk berbagai pengujian infeksi DENV-3.
Implementasi Media Audio Visual dalam Pembelajaran IPA Biologi Materi Virus pada Siswa Kelas XA DI MA Qur’aniyah Batu Kuta Narmada Dalam Meningkatkan Aktivitas Belajar Tahun Pelajaran 2015/2016
Authors: Hidayat Fendi , Suhirman Suhirman , Fadli Adi
Published: July 2018

Terkait  dengan  rumusan  masalah  yang  diangkat,  maka  tujuan yang ingin dicapai dalam penelitian ini adalah untuk mengetahui apakah ada peningkatan  aktivitas  belajar  siswa  Kelas  X  A  dengan mengimplementasikan media audio visual dalam pembelajaran IPA biologi materi  virus  di  MA  Qur‟aniyah Batu  Kuta Naramada Tahun Pelajaran2015/2016.Penelitian ini   mengunakan penelitian tindakan kelas (PTK).Subjek penelitian ini adalah siswa kelas X MA Qur‟aniyah Batu Kuta Narmada Tahun Pelajaran 2015/2016 yang bejumlah 31 yang dijadika Subjek penelitian. Teknik  pengumpulan  data  meng-gunakan  Observasi, Dokumentasi. Dari analisi observasi siklus I mendapatkan hasil 60% dengan criteria siswa yaitu cukup Aktif di dalam proses pembelajaran, sedangkan pada siklus II menda-patkan hasil 86%. Dari hasil siklus I dengan siklus II, maka peneliti dapat mengemukakan terdapat  peningkatan  aktivitas  belajar  dengan  implementasikan  Media Audio Visual  Pada siswa Kelas X MA Qur‟aniyah Batu Kuta Narmada m Tahun Pelajaran 2015/2016. Dengan demikian Implementasi Media Audio Visual dapat meningkatkan aktivitas belajar siswa.
Optimalisasi Tingkat Pertumbuhan (Growth Rate) dan Mortalitas (Survival Rate) Ikan Nila (Oreochromis Niloticus) dengan Enzim Papain Kasar
Authors: Ihsan Muhsinul , Mahsul Alwan
Published: July 2018

Ikan Nila adalah salah satu ikon penyelamat perkembangan budi daya ikan air tawar karena teknologi pemeliharaannya sudah berkembang dengan baik. Salah satu permasalahan dalam pembudidayaan Ikan Nila adalah mahalnya biaya pakan. Solusi untuk mengatasi hal ini adalah pengayaan pakan yang memiliki kualitas rendah dengan enzim papain kasar. Tujuan penelitian ini adalah untuk mengetahui pengaruh enzim papain kasar terhadap pertumbuhan dan survival rate Ikan Nila. Penelitian ini telah dilakukan selama 30 hari di kolam budidaya milik masyarakat Gubuk Barat I Desa Mamben Daya Kec. Wanasaba Lombok Timur. Terdapat 4 tahapan dalam prosedur kerja yang digunakan yaitu: preparasi enzim papain kasar, pencampuran enzim papain kasar dengan pelet, pengujian pelet yang telah dicampur dengan enzim papain kasar, dan evaluasi pengaruh enzim papain kasar. Hasil penelitian menunjukkan bahwa enzim papain kasar mampu meningkatkan pertumbuhan Ikan Nila sebesar 4 Kg selama 30 hari, hampir empat kali lipat lebih tinggi dibandingkan pertumbuhan Ikan Nila yang tidak diberikan enzim papain kasar. Survival rate Ikan Nila yang ditambahkan enzim papain kasar sebesar 78,09%, lebih besar dibandingkan survival rate Ikan Nila yang tidak ditambahkan enzim papain kasar. Enzim papain kasar mampu meningkatkan pertumbuhan Ikan Nila secara signifikan. Akan tetapi, belum mampu menekan tingkat mortalitas Ikan Nila secara signifikan.
Variasi Genetik Kacang Komak (Lablab purpureus (L.) Sweet) Menggunakan Penanda RAPD di Pulau Lombok, Nusa Tenggara Barat
Authors: Jayanti Ervina Titi , Kasiamdari Rina S. , Daryono Budi S.
Published: July 2018

Penanda RAPD digunakan untuk evaluasi hubungan genetik diantara 26 aksesi kacang komak di Pulau Lombok. Koleksi sampel menggunakan metode jelajah di 4 kabupaten ada di Pulau Lombok, isolasi DNA menggunakan kit Nucleon Phytopure. Amplifikasi DNA menggunakan PCR dengan 5 primer yaitu L 11 (5’- ACGATGAGCC-3'), OPB 8 (5'-GTCCACACGG-3'), OPB 15 (5'-CGAGGGTGTT-3'), OPB 17 (5'-AGGGAACGAG-3'), dan OPH 6 (5'-ACGCATCGCA-3'). Prosedur PCR yang dilakukan mengacu pada yang telah dilakukan oleh Williams et al. (1990). Analisis kluster menggunakan UPGMA dengan menggunakan koefisien Jaccard. Pada koefisien 0,71 atau nilai similaritas 71% anggota kacang komak yang ada di P. Lombok mengelompok membentuk 4 klaster utama yaitu klaster I, II, III, dan IV.  Pola pengelompokan kacang komak yang ada di P. Lombok secara molekular tidak mencerminkan pola pengelompokan berdasarkan karakter morfologi polong maupun wilayah geografis.
Flavonoids as Putative epi-modulators: Insights into their Binding Mode with BRD4 Bromodomain using Molecular Docking and Dynamics.
Authors: Prieto-Martínez Fernando Daniel , Medina-Franco José Luis
Published: July 2018

Flavonoids are widely recognized as natural polydrugs, given their anti-inflammatory, antioxidant, sedative and antineoplastic activities. Recently, different studies have shown that flavonoid have the potential to inhibit BET bromodomains. Previous reports suggest that flavonoids are putative inhibitors of the ZA channel due to their orientation and interactions with P86, V87, L92, L94 and N140. Herein, a comprehensive characterization of the binding mode of the biflavonoid amentoflavone and fisetin is discussed. To this end, both compounds were docked with BRD4 using four docking programs. Results were post-processed with protein-ligand interaction fingerprints. To gain further insights into the binding mode of the two natural products, docking results were further analyzed with molecular dynamics. Results showed that amentoflavone makes numerous contacts in the ZA channel, as previously described for flavonoids and kinase inhibitors. It was also found that amentoflavone can potentially make contacts with non-canonical residues for BET inhibition. Most of these contacts were not observed with fisetin. Based on these results, amentoflavone was tested for BRD4 inhibition, showing activity in the micromolar range. This work may serve as basis for scaffold optimization and further characterization of flavonoids as BET inhibitors.
An Innovative Bidirectional DC-AC Converter to Improve Power Quality in a Grid-Connected Microgrid
Authors: Bissey Sebastien , Jacques Sebastien , Reymond Cedric , Le Bunetel Jean-Charles
Published: July 2018

The management of the electrical energy still raises a huge interest for end-users at the household level. Home electricity management systems (HEMS) have recently emerged both to warrant uninterruptible power and high power quality, and to decrease the cost of electricity consumption, by either shifting it in off peak time or smoothing it. Such a HEMS requires a bidirectional DC-AC converter, specifically when an energy transfer is required between a storage system and the AC-grid, and vice versa. This article points out the relevance of an innovative topology based on sinusoidal waveforms from the generation of sine half-waves. Such a topology is based on a DC-DC stage equivalent to an adjustable output voltage source and a DC-AC stage (H-bridge) which are in series. The results of a complete experimental procedure prove the feasibility to improve the power quality of the output signals in terms of total harmonic distortion (THD-values about 5%). The complexity of the proposed converter is minimized in comparison with multilevel topologies. Finally, wide band-gap semiconductor devices (SiC MOSFETs) are helpful both to warrant the compactness and the high efficiency (about 96%) of the bidirectional converter, whatever its operation mode (inverter or rectifier mode).
KOMPETENSI TUTOR KESETARAAN PAKET C DAN HASIL BELAJAR WARGA BELAJAR PADA PUSAT KEGIATAN BELAJAR MASYARAKAT
Authors: Hadiyanti Puji
Published: July 2018

Community learning center (PKBM) tutors should have professional pedagogic, personal and social competencies. This study aimed at investigating whether the tutors in PKBM Miftahul Jannah, East Jakarta  have such competencies. This study also investigated the learners. achievement . A survey using questionnaire was conducted for that purpose. This study reveals that the tutors have such competencies whereas the learners' achievement vary. This study also provides suggestions to improve the tutors quality.
MODEL KREATIF PEMBELAJARAN P4 PADA PENDIDIKAN KECAKAPAN HIDUP PRODUKSI JAMUR MERANG
Authors: Yudi Yudi
Published: July 2018

The instruction ofP4 was found not satisfactory to meet the instruction objectives employing the traditional ,nuuel. lt71S research developed a creative model for P4 instruction particularly for life skills using descriptive methods. Instruments to collect data included check list, evaluation sheets for tryout and implementation. After try out process and revision, this research could developed P4 Instruction Model for Life Skill to Produce Mushroom. This mode/ has been able to solve the instructional problems in UPTD SKB in Bekasi District.
MODEL PELATIHAN TERPADU UNTUK MENINGKATKAN FUNGSI DAN PERAN SOSIAL ANAK DALAM MEMBINA KEMANDIRIAN
Authors: Hadita Akmala
Published: July 2018

Some problems are often faced in educating children to be self-reliant. On the other hand independency is much required in their future life. This research conducted in RSPA Cisurupan, Garut, in April 2010 until April 2011, aimed at developing an integrated training model to improve function and social roles of the children in the independency. Employing research and development design with planning, preparation, implementation and maintaining, as well as evaluation, the model development involved the parents or the family members and the children. The research produced the Integrated Training Model to Improve the Function and Social Roles of the Children in Developing the Self-reliance, which had been validated in this research.
PENGEMBANGAN MODEL PEMBELAJARAN KEAKSARAAN FUNGSIONAL BERBASIS POTENSI PERTANIAN BAGI PEMBERDAYAAN KOMUNITAS ADAT TERPENCIL
Authors: Mahu Saing
Published: July 2018

The problems of illiteracy and poverty have not been optimally overcome through the development of functional literacy program based on local potential. This research aims to develop literacy-based learning model to empower the local potential of the Remote Indigenous Communities. This study employed research and development approach and the data were collected using questionnaires, interviews, and documentation study. The respondents consisted of the program, traditional leaders / community, tutors, and program participants in five villages PKBM organizers, District Waiapo . The research producedliteracy learning model which has significant positive effect on the empowerment of remote indigenous communities in the functional literacy program.
Peningkatan Induksi Kalus Embriogenik dan Konversi Embrio Somatik Kopi Robusta Klon BP 308
Authors: Ibrahim Meynarti Sari Dewi , Hartati RR. Sri
Published: July 2018

Robusta coffee (Coffea canephora) is a cross-pollinated plant, therefore vegetative propagation is necessary to ensure identical traits with parents, such as tissue culture techniques through somatic embryo. The study aimed to find the effect of plant growth regulator 2.4-D and thidiazuron in inducing embryogenic callus, by adding incision area on leaf explant, and to evaluate addition of GA3 in increasing somatic embryo conversion. The study was conducted from December 2014 to June 2016 in the Tissue Culture Laboratory, IAARD, Bogor. The research consisted of 2 stages. Stage 1 used a complete randomized design of 2 factors; the first factor was a combination of plant growth regulator 2.4-D (1.0 and 2.0 mg/l) and thidiazuron (1.0; 3.0; and 5.0 mg/l), the second factor was leaf incision (slashed and unslashed). Stage 2 used a complete randomized design, with GA3 treatment at different concentrations (0.0; 0.5; and 1.0 mg/l). Observed variables were percentage of callus formation, fresh weight of callus, number of torpedoes, number of somatic embryos at cotyledon stage, and number of germinated embryo. The results showed growth regulatory treatments influenced the percentage of embryogenic callus formation and fresh weight of callus. Extra incision on leaf showed no effect in  embryogenic callus induction. Embryogenic callus inducted using 2.4-D 1.0 mg/l + thidiazuron 5.0 mg/l medium which  then regenerated in ½ MS medium added with kinetin 2 mg/l exhibited  the highest number of germination.  Adding GA3 0.1 mg/l in regeneration medium is recommended to increase somatic embryos of Robusta coffee BP 308 clone.
Keragaman Genetik antar Klon Kopi Robusta Lokal Pagar Alam berdasarkan Analisis Marka SSR
Authors: Syafaruddin Syafaruddin , Dani Dani , Pabendon Marcia Bunga
Published: July 2018

Robusta coffee (Coffea canephora var. robusta) is the most extensive developed in Indonesia, including Pagar Alam, South Sumatra. In the last few decades, many farmers in Pagar Alam conducted clonal selection and rehabilitation of Robusta coffee trees that generated indigenous clonal populations. This pattern in the long period can damage important alleles and reduce the genetic diversity of indigenous Robusta coffee in farmland. The research aimed to know the genetic diversity among indigenous Robusta coffee clones developed in Pagar Alam based on SSR markers. The study was conducted at Molecular Biology Laboratory, Cereals Research Institute, Maros, from February to April 2017. Molecular characterization of 19 indigenous Robusta coffee clones was conducted using 33 polymorphic SSR markers. The resulting binary data was then analyzed using PowerMarker program to determine polymorphism value (PIC), number and diversity of alleles, and heterozygosity values. The results showed that 33 polymorphic SSR loci produced 134 alleles with an average of 4.06 alleles/locus, whereas PIC values ranged from 0.09–0.77 with an average of 0.48. Of the 33 SSR loci, 19 loci (57.58%) exhibited very informative PIC value (> 0.55). Dendrogram generated using NTSYS program divided 19 indigenous Robusta coffee clones into 4 clusters at 0.53 similarity coefficient. KPA41clone was separated in its own cluster, potentially crossed with other clones. Based on genetic distance values >0.55, could arrange 14 combinations of interclonal crosses that potentially increase the genetic variability of indigenous Robusta coffee from Pagar Alam.
Analisis Penyusunan Prioritas Kegiatan dalam Mendukung Diberlakukannya Kewajiban Fermentasi Biji Kakao
Authors: Sudjarmoko Bedy , Listyati Dewi , Hasibuan Abdul Muis
Published: July 2018

Cocoa is a strategic commodity with an important role in Indonesian economy. Despite being the world's third largest cocoa producer and exporter after Ivory Coast and Ghana, Indonesia still faces a number of problems in production, processing, and marketing. The government issued Permentan Nomor 67/Permentan/OT.140 /5/2014 which aims to improve the competitiveness and added value of Indonesian cocoa, support national cocoa postharvest industries, protect the consumers of unqualified cocoa beans, increase cocoa farmers’ income, and facilitate the tracing for production and circulation deviation. The study aimed to develop a strategic priority recommendation in achieving the goals of Permentan Nomor 67/ Permentan/OT.140/5/2014. The study was conducted in West Sumatra, West Java, East Java, Yogyakarta, and DKI Jakarta from January to December 2016. The study was conducted by survey method and the data was analyzed analytic hierarchy process (AHP). The results indicated that priorities should be put forward on: 1) implementing national regulation on cocoa beans fermentation consistenly and continuously; 2) product diversification with affordable and achievable cost and technology; 3) a massive, continuous, and intensive campaign on social awareness of the importance of sustainable energy; 4) stimulating small to big scale cocoa processing industries; 5) intensification, rehabilitation, and rejuvenation of the cocoa farming to meet the domestic demand for cocoa.
Eficiencia comunicativa de las Páginas Web en el caso de la gestión turística de los Sitios Patrimonio de la Humanidad en España
Authors: Teruel Serrano María Dolores
Published: July 2018

Este trabajo desarrolla la elaboración de un cuestionario metodológico denominado de Eficiencia Comunicativa (CEC) que ha servido para analizar los valores comunicativos de las páginas web de los sitios Patrimonio de la Humanidad españoles a partir de los principios del Turismo Sostenible de la UNESCO. El CEC valora las capacidades de las páginas web en relación a: (i) las relaciones turismo-patrimonio, (ii) la formación en turismo y (iii) la comunicación estratégica. Los resultados revelan que no todas superan la valoración lo cual advierte de una infravaloración de la comunicación estratégica.
Energía Eólica y Paisaje. Identificación y cuantificación de paisajes afectados por instalaciones eólicas en Andalucía
Authors: Díaz Cuevas María del Pilar , Fernández Tabales Alfonso , Pita López María Fernanda
Published: July 2018

Este artículo analiza la distribución territorial y paisajística de los parques eólicos en Andalucía, identificando y cuantificando las superficies afectadas por cambios paisajísticos como consecuencia de la implantación de estas infraestructuras. Ello se lleva a cabo a partir de la generación de una geodatabase de energías renovables que recoge información espacial detallada de estas infraestructuras, con un nivel de precisión hasta el momento inédito en Andalucía. El uso de las capacidades analíticas de los Sistemas de Información Geográfica permite la definición y generación de nuevos indicadores paisajísticos relacionados con las instalaciones de energía eólica, no aplicados previamente para la Comunidad Autónoma Andaluza.
La Gomera: Una isla en manos de la gran propiedad territorial isleña
Authors: Jerez Darias Luis Manuel , Martín Martín Víctor
Published: July 2018

El presente artículo se plantea como un intento de sobrepasar los tradicionales argumentos
que se han esbozado al hablar de la propiedad de la tierra en la isla de La Gomera. Partiendo
de un minucioso análisis empírico de las fuentes catastrales, hemos sido capaces de finiquitar
un discurso idealista y carente de rigor científico, el cual afirma que La Gomera ha sido un
territorio de minifundio, factor causante del atraso insular. Por tanto, y al contrario de esa línea
de interpretación, con este estudio demostramos que ha sido una minoría, la de los grandes
propietarios, el grupo que ha concentrado históricamente el grueso de las tierras en La Gomera.
Las ayudas agrarias y sus repercusiones sobre la agricultura familiar en la última reforma de la Política Agraria Común (2014-2020) de la Unión Europea: ¿Cambiar para que todo siga igual?
Authors: Segrelles Serrano José Antonio
Published: July 2018

La última reforma de la Política Agraria Común (PAC) de la Unión Europea (UE) para
el periodo 2014-2020 no augura demasiados cambios sustanciales respecto a sus estrategias
tradicionales pese a las propuestas formales y oficiales. La nueva PAC ha resultado ser más
compleja, pero esto no significa que vayan a cesar los desequilibrios territoriales y las desigualdades productivas a la hora de su aplicación real y que ya no se beneficien de las ayudas comunitarias aquellos agentes que menos las necesitan.
El Distrito 22@Barcelona como elemento de relocalización de las empresas de la ciudad. Un análisis de las antiguas y las nuevas ubicaciones de las sedes empresariales
Authors: Paül i Agustí Daniel
Published: July 2018

El análisis de las repercusiones de una transformación urbana suele centrarse en el propio
espacio transformado. No obstante, los efectos pueden ser más amplios e incluir toda la
ciudad. La investigación analiza las repercusiones generadas en la ciudad de Barcelona por
el proceso de traslado de las distintas compañías hacía el distrito tecnológico 22@Barcelona.
Los resultados apuntan a que la mayoría de empresas se han trasladado des de otras áreas
de la ciudad, siendo la llegada de nuevas compañías de otros contextos extremadamente
limitada. En este sentido, el nuevo distrito ha contribuido más a una relocalización dentro
Barcelona que a un fortalecimiento de su tejido económico. Igualmente, la relocalización
ha contribuido a generar efectos en otras áreas de la ciudad, como la pérdida de puestos de
trabajo en algunos barrios o cierta turistificación del centro histórico.
El estudio geográfico de la energía: Una aproximación histórica al estado de la cuestión
Authors: Herrero Luque Daniel , Baraja Rodríguez Eugenio
Published: July 2018

De entre las actividades antrópicas la producción energética es una de las que ha generado
mayor impacto espacial y transformación del paisaje. La comunidad de geógrafos, si
bien se interesó de forma temprana por los recursos energéticos o su aprovechamiento y consumo, no ha abordado hasta el nuevo siglo la dimensión paisajística de la energía. El artículo analiza a partir de un trabajo de revisión bibliográfica el estado de la cuestión de los estudios geográficos sobre la energía. Los resultados identifican las orientaciones con las que ha sido abordada la “geografía de la energía” y las líneas de investigación presentes.
El papel de la información geográfica en el patrimonio cultural inmueble: Caso práctico de estudio de las fortificaciones medievales de la Cuenca del Río Henares en la provincia de Guadalajara (España)
Authors: Gamo Salas María del Mar
Published: July 2018

A lo largo de la historia, las distintas civilizaciones del mundo han ido dejando sus huellas
a las generaciones venideras. Ese legado otorgado presenta una fuerte vinculación con
el lugar en el que se establecieron dichas culturas. El presente trabajo analiza cómo el ser
humano actual comprende ese vínculo entre el patrimonio cultural inmueble y su localización
geográfica, y qué valor le asigna. Este análisis se ha realizado aplicado a una muestra
significativa ubicada en el Reino de España: las fortificaciones medievales de la cuenca del
río Henares en la provincia de Guadalajara.
El papel de los agentes en la dinámica urbanística y territorial durante el boom inmobiliario (1996-2006) en la llanura del Alt Empordà (Girona)
Authors: Cuadrado Ciuraneta Sergi
Published: July 2018

El artículo analiza el papel de los agentes en la dinámica urbanística y territorial durante
los años del boom inmobiliario (1996-2006): administraciones públicas (ayuntamientos y
Generalitat), plataformas de defensa y movimientos vecinales, agentes privados vinculados a
la actividad urbanística (propietarios de suelo y promotores inmobiliarios) y empresariado de
los sectores tradicionalmente relevantes (turístico y agropecuario). El estudio se realiza sobre
la llanura del Alt Empordà (Girona), que puede resultar representativa de otros espacios litorales de la geografía española.