bluuebunny/crossref_metadata_2025 huggingface dataset:
The Medium is the Messenger A Quantitative Study on the Relation between Social Media Services and Neighbourhood Social Interactions
Authors: Üblacker Jan , Liebig Simon , Hamad Hawzheen
Published: April 2024

Internet-based social networking services (ISNS) like Facebook, Instagram, Twitter, and others have revolutionized the way people connect, enabling interactions across great distances. This has sparked a debate about the impact of ISNS use on face-to-face contact, particularly within
neighbourhoods. Some argue that ISNS diminish the significance of local physical place and hinder meaningful interactions, especially among neighbours. Conversely, others view ISNS as tools that foster new forms of connectedness and enhance relationships within neighbourhoods by creating opportunities
to engage with existing peers. However, there is a significant knowledge gap regarding the varying effects of ISNS on offline social interaction within neighbourhoods. Do different ISNS, including messenger services, Facebook, Instagram, Twitter, and neighbourhood-specific social networks
(e.g.nebenan.de), 1 have distinct effects on offline social interaction within neighbourhoods? Are there differences in usage between native residents and migrants? We analyse data from a 2022 postal survey conducted in two German cities (Essen and Cologne), involving 2, 676 residents in 166
neighbourhoods. The results from our multiple linear regression model show that the impact of different ISNS on social interactions varies. Messenger services and neighbourhood-specific social networks have a positive impact on social interactions within the neighbourhood. However, popular
social media platforms like Facebook, Instagram, and Twitter do not significantly affect social interactions within the neighbourhood. Additionally, individuals from the native population do have more social interaction with their neighbours compared to those with a migration background.
Can Neighbourhoods Save the Smart City?
Authors: Aurigi Alessandro
Published: April 2024

For decades, accounts and speculations on the emergence of digitally-augmented environments have suggested utopian, and dystopian, visions of increased spatial fluidities – doing anything from anywhere – in which the role of specific places could become redundant. The emergence
of smart urbanism, through technocratic visions of central, algorithmic control, could materialize such centrifugal detachment from place and local context, as it operates a shift of agency from space and community to code. Are, therefore, the hyper-local scale, and neighbourhoods, relevant
entities in our increasingly digital urban environments? This paper makes a case for the smart neighbourhood not as a plain, pre-determined, functional sub-unit of a centrally controlled and automated smart metropolis, but as a radically divergent – yet necessarily complementary –
dimension of it. The discussion looks at the scales of the locale – and of the hyper-local – as the enablers of a re-combined and re-energized spatial and digital agency. It discusses the importance of local appropriation and contextualization of technology – as opposed to
the 'off-the-shelf' adoption of civic infrastructural systems and management software, and of enabling significant social innovation and community involvement and participation. However, once the importance of re-combining space, community and technology at the local scale has been explored,
the paper discusses how the point is not opposing the smart neighbourhood to the smart city through a simplistic bottom-up vs top-down dualist vision, but rather reflecting on how these dimensions should work together. Design and development strategies that aim to conjugate the very bespoke
and pilot with the scalable, and the qualitative with the quantitative, while enabling local innovation and experimentation, are needed to envisage a grounded, sustainable, and effective smart city.
Neighbourhoods still Matter Because Housing Market Actors Believe They Matter
Authors: Galster George C.
Published: April 2024

The urban neighbourhood – though increasingly assailed as a problematic spatial construct – still matters in contemporary societies because it is a crucial unit of reference in metropolitan housing markets. The logic is as follows. Key housing market actors – households,
owners, developers, and agents – believe that the local area in which they live, own property, or try to sell property influences their own wellbeing for a number of social-psychological and/or economic reasons. Because these people then act on their neighbourhood-related beliefs in
a variety of ways, this implies that neighbourhoods are important: they generate collective behavioural responses. Put more succinctly, neighbourhoods must still matter because housing market actors believe they matter and then behave based on these beliefs. Evidence to support this logic
is assembled here from a wide variety of interdisciplinary sources. For households, we observe the strong relationship between neighbourhood conditions and satisfaction, housing search, and intra-urban mobility. For property owners and developers, we observe how neighbourhood attributes strongly
influence property values and, relatedly, the virulence of NIMBY protests when changes in these a ributes are considered threatening. For housing agents, we see continued evidence of discriminatory exclusion and geographic steering on the basis of neighbourhood racial/ethnic and income composition.
O ato de vacinar como desdobramento do direito coletivo à saúde: Da possível aplicação da teoria dos deveres fundamentais
Authors: Nunes Danilo Henrique , Montes Netto Carlos Eduardo , Oliveira Sergio Martin Piovesan
Published: April 2024

Com a chegada da pandemia de Covid-19, considerada o maior desafio de saúde pública do século 21, foram verificadas inúmeras controvérsias e polêmicas contemplando os planos de imunização e o ato de se vacinar em si, sobretudo envolvendo a contraposição entre direitos individuais e direitos coletivos. O presente artigo científico busca a realização de uma análise sobre a vacinação com base no direito coletivo à saúde, tendo como pano de fundo a aplicação da Teoria dos Deveres Fundamentais. Para tanto, fora realizada uma pesquisa que contou com as contribuições doutrinárias e jurisprudenciais, além da legislação e de achados em periódicos, com emprego do método hipotético-dedutivo para fomentar a discussão sobre o tema e apresentar como hipótese o caminho do cumprimento dos deveres coletivos, dentre eles o da vacinação obrigatória. O resultado alcançado neste estudo foi o de que o Estado é um interventor legítimo ao estabelecer o dever de se vacinar como um elemento para cumprir com o dever fundamental do indivíduo em zelar pela saúde pública. É uma forma de potencializar o direito difuso à saúde pública.
A moralidade administrativa e sua densificação como direito fundamental
Authors: Remedio José Antonio , Maciel Neto Aluisio Antonio
Published: April 2024

A presente pesquisa tem por objeto analisar a moralidade administrativa e sua densificação como direito fundamental no Estado Democrático de Direito brasileiro. A Constituição Federal de 1988, em mais de uma oportunidade, faz referência normativa à moralidade, tendo, inclusive, erigido a moralidade como princípio constitucional expresso de obediência obrigatória pela administração pública direta e indireta de qualquer dos poderes da União, dos Estados, do Distrito Federal e dos municípios. As normas, enquanto gênero, têm como espécies os princípios e as regras. A doutrina controverte-se sobre a natureza jurídica da espécie normativa representada pela moralidade administrativa. A legislação brasileira, formalmente, não estabelece a definição ou o conceito da moralidade administrativa. Tem-se, em síntese, que a moralidade administrativa, na condição de norma jurídica, não se resume a mero princípio da administração pública, mas também ostenta o caráter de regra e, elencada como direito fundamental do cidadão, cumpre a função de alicerce do Estado Democrático de Direito, inclusive como instrumento que contribui para o cumprimento dos objetivos da Constituição Federal brasileira na consecução do bem comum. O método utilizado é o indutivo e o procedimento é o de investigação bibliográfica, doutrinária e legislativa.
Perfil sociodemográfico e comportamental de pacientes com Covid-19 na região central do Rio Grande do Sul
Authors: Birrer Jucelaine Arend , Santos Gilberto Martins , Birrer Caroline Arend , Ozório Lisiane Alves , Calixto Roseri de Freitas , Lima Graziele Pires , Tavares Rudinei , Koglin Ivete Martins
Published: April 2024

Identificar a população afetada pela Covid-19 é essencial para tomada de decisão quanto ao tratamento da patologia bem como de suas sequelas. Para isso, são necessários estudos que caracterizem os acometidos, a fim de promover ações de saúde que deem suporte à continuidade do cuidado e atendam as demandas advindas do processo de adoecimento causadas pelas sequelas da doença. Objetivo: analisar o perfil epidemiológico e comportamental dos usuários diagnosticados com Covid-19 em um hospital de alta complexidade da região central do estado do Rio Grande do Sul (RS). Método: trata-se de uma análise quantitativa, retrospectiva, de natureza descritiva, de prontuários de usuários com diagnóstico confirmado para Covid-19, internados no período de 2020 a 2022, totalizando vinte e seis meses. Resultados: Foram analisados 664 prontuários de pacientes, com predomínio de adultos e idosos.  A maior incidência de pacientes internados foi da região central do RS, de nacionalidade brasileira, sexo masculino, raça branca, casados e com primeiro grau incompleto. Em relação a variável comportamento de risco, houve predomínio de não fumantes e não etilistas. Quanto ao hábito comportamental relacionado à imunização para Covid-19, na maioria dos prontuários não constava a informação se o paciente havia ou não realizado a vacina. Conclusão: este estudo indica e enfatiza a necessidade de políticas públicas que atendam às necessidades deste público – pacientes pós-Covid-19 –, dentre elas o monitoramento longitudinal, como estratégia de prevenção de novos agravos, e a promoção e educação em saúde, visando a qualidade de vida e assegurando a equidade do cuidado.
Singularidad individual versus “singularity”. Una crítica al transhumanismo desde el pensamiento de Søren Kierkegaard
Authors: Dobre Catalina Elena , García Pavón Rafael
Published: April 2024

Si bien existen algunos intentos de repensar el tema de la tecnología desde la filosofía de Søren Kierkegaard, no existe todavía un diálogo directo con la postura transhumanista. En este artículo proponemos un acercamiento inédito, entendido como una crítica, desde el pensamiento de Kierkegaard al transhumanismo y su concepto de singularity. Primero, analizamos el modo en el que los transhumanistas entienden el concepto de singularity y sus limitaciones; después, apoyándonos en la filosofía de Kierkegaard, defendemos que la única singularidad posible y real es la persona humana como relación primigenia, fuente de angustia y libertad, pecado y amor, espíritu. Defendemos también que esta relación no puede ser replicada por una creación artificial.
Del isomorfismo al isodinamismo en la filosofía de Gilbert Simondon
Authors: Builes Isabella
Published: April 2024

En el presente artículo se presenta un paso del isomorfismo al isodinamismo en la filosofía de Gilbert Simondon. Para ello, se explica el argumento del isomorfismo y algunas de sus implicaciones y críticas. Posteriormente se exponen algunos elementos generales sobre la teoría de la individuación del ser en devenir desde la perspectiva de Simondon. Finalmente, se analiza en qué consiste el paso del isomorfismo al isodinamismo y se ofrecen algunos ejemplos de posibles aplicaciones del isodinamismo. Básicamente, este proceso del isomorfismo al isodinamismo consiste en un cambio de perspectiva que implica pasar de la semejanza entre estructuras a la analogía entre operaciones diversas, por ejemplo, entre los modos de funcionamiento presentes en distintos niveles del ser (fisicoquímico, biológico y psicosocial).
Para una genealogía de la biopolítica italiana: Roberto Esposito y la recepción temprana de los cursos de Michel Foucault
Authors: Castro Edgardo
Published: April 2024

Este artículo se ocupa de la recepción de la noción foucaultiana de “gubernamentalidad” en el pensamiento de Roberto Esposito a partir de la traducción al italiano de las lecciones de Foucault de los años 1977 y 1978 en el Collège de France. En primer lugar, se exponen los diferentes contextos de recepción de estas lecciones, en particular en el ámbito anglosajón de los estudios sobre la gubernamentalidad y en el de la crisis del marxismo italiano de finales de los setenta. En segundo lugar, se analiza la posición de Foucault en sus cursos de estos años desde la perspectiva de la oposición entre maquiavelismo y antimaquiavelismo en vista, precisamente, de la recepción italiana. Por último, se aborda la recepción de la noción de “gubernamentalidad” por parte de Roberto Esposito en su obra de 1980, La politica e la storia. El artículo muestra la importancia de esta recepción temprana de las lecciones de Foucault respecto de la formación de la corriente biopolítica italiana y, sobre todo, sus especificidades.
Analysis and research on the dynamic characteristics of shock absorber based on ADAMS
Authors: Chen Kun
Published: April 2024

In order to effectively improve safety and stability during transportation, a shock absorber with buffering and self-locking functions was designed. Based on the rigid flexible coupling technology, the working state and dynamic response of the shock absorber were simulated and analyzed. The linear spring was treated as a flexible body, and the cam button, guide pillar, and base were treated as rigid bodies. The modal neutral files required for the rigid flexible coupling dynamic analysis were generated. Based on ADAMS, a dynamic simulation model was established, replacing a part of the rigid model with a flexible model and conducting load response analysis on it. To further improve the vibration reduction effect, the performance of the contact material of the shock absorber was analyzed. Through the calculation of dynamic characteristics, it could be known that the self-locking mechanism had no dead points, and the vibration reduction force response stability was high, meeting the working requirements.
Study on the effect of self-melting snow materials on the properties of asphalt mixture
Authors: Wang Hao , Wang Xiaosen
Published: April 2024

Adding self-melting snow material to asphalt pavement can improve driving safety in winter weather. Self-melting materials can melt the snow on the road surface, without too much negative impact on asphalt pavement. Two commonly used self-melting snow materials are particle type and powder type. Through indoor experiments, the effects of two self-melting snow materials on the high-temperature performance, low-temperature performance, water stability, and anti-stripping performance of asphalt mixtures are compared. The experiment shows that these self-melting snow materials have little effect on the high-temperature and low-temperature performance of the asphalt mixture, and the low-temperature performance of the mixture decreased after freeze-thaw environment. After freeze-thaw cycle or immersion, the snow melt components in the mixture gradually precipitate, leading to the water stability and anti-spalling performance.
Research on the location of measurement points in explosion shock wave pressure testing
Authors: Zhong Kai , Wang Liangquan , Kong Deren , Xu Chundong
Published: April 2024

Shock wave is an important damage element in ammunition explosion and one of the important technical indicators for evaluating its damage power. Accurately measuring shock wave pressure is of great significance for guiding ammunition design and evaluating damage power. The testing environment in the explosion field is harsh, and the measurement of shock wave pressure is affected by various influencing factors, resulting in inaccurate measurement results and low reliability. The location of pressure measurement points directly affects the measurement results of surface reflection pressure and free field pressure. This study is based on the display explosion dynamics simulation software AUTODYN to conduct simulation analysis of the propagation law of explosion shock wave pressure, analyze the height variation of the three wave point trajectory during the ammunition explosion process, and clarify that the surface reflection pressure measurement points need to be located in the Mach reflection zone, and the free field pressure measurement points need to be located above the height of the three wave points. The research results provide theoretical support for accurate testing of explosion shock wave pressure and have significant engineering application value.
Enhanced photocatalytic CO2 reduction via single-atom Au anchored on ZnIn2S4 nanosheets
Authors: Zhang Zhaoyang , Rao Houdong , Zhang Dongyang , Zhang Ling , Cheng Wei
Published: April 2024

In this study, we systematically investigated the effect of single-atom gold (Au) loaded on ZnIn2S4 nanosheets on the photocatalytic reduction of carbon dioxide (CO2). Utilizing a photodeposition method, we successfully dispersed single-atom Au uniformly on the surface of ZnIn2S4 nanosheets. Under simulated sunlight irradiation, the Au-loaded catalyst demonstrated a higher yield and selectivity in the CO2 reduction reaction compared to the pure ZnIn2S4 nanosheets. Surface photovoltage testing revealed that the addition of Au significantly enhanced the separation efficiency of photo-generated charge carriers, thereby improving the photocatalytic efficiency. Density functional theory calculations indicated that the loading of single-atom Au reduced the reaction energy barrier from CO2 to CO, enhancing the selectivity of photocatalytic CO2 reduction. This research not only developed an efficient catalyst for CO2 reduction but also provided deep insights into the mechanism of single-atom catalysts in the photocatalytic CO2 reduction process through extensive experimental and theoretical analysis.
Improvement of the control system with the drive of high voltage arc furnaces
Authors: Abdushukur Eshmirzaev Mirzokhid , Shirinboy Narzullayev Bobur
Published: April 2024

The article presents a method for improving the control system of electric motors driving the electrodes of high-voltage arc furnaces. The developed method today in the field of metallurgy is of great importance in solving problems such as at the first stage of melting and casting metal in arc steelmaking furnaces, when the electrodes are initially lowered into the working bath, the connection point breaks as a result of contact with a metal plate, the incompatibility of the formation of an electric arc on the electrodes, holding the electrodes at a certain distance from the metal charge. Also, automatic control of the speed of movement of the electrodes, i.e. (the time of formation of an electric arc in the electrodes, which reduces the speed of its movement, the time of lifting the electrodes, lowering, increasing the speed of movement), is relevant for solving problems such as welding electrodes into a metal shackle. The main purpose of introducing this method into practice is to reduce electricity consumption and ensure reliable operation of high-voltage electric arc furnaces by reducing the melting time of metal.
Analysis of the amount and structure of solid particles PM released into the city’s atmospheric air by motor transport
Authors: Jailaubekov Yerkin A. , Amirgaliyeva Saltanat N. , Baubekov Ermek E. , Yakovleva Natalia A. , Askarov Seilkhan A. , Tazabekov Asset J.
Published: April 2024

Atmospheric air pollution with fine particles PM2.5 and PM10 is one of the main environmental problems of the city. This paper presents the results of the study of quantitative and structural components of solid particles’ emissions in the city of Almaty, released during the operation of cars: by an engine with exhaust gases, by tire abrasion, by braking devices (linings) and road pavement wear. РM solid particles in the amount of 543.2 tons are released annually into the atmospheric air of Almaty by motor transport. The bulk PM10 is released totally from the tires, brakes and road – 65.4 %, from the engine – 34.6 %. On diesel buses and trucks, the bulk РM particles’ emissions are released from the exhaust gas engines. Recommendations are given to reduce PM particles emitted by motor transport.
Liquid induced vibrations of partially liquid-filled elastic cylindrical-conical shells
Authors: Choudhary Neelam , Degtyarev Kirill , Strelnikova Elena , Rana Saurabh
Published: April 2024

The main objective of this study to develop efficient numerical techniques based on coupled finite and boundary element methods to estimate natural vibration frequencies in compound reservoirs with liquid. Elastic structures composed of cylindrical and conical shells connected by rings have been examined. The space between the shells is filled with an ideal, incompressible fluid. The advantage of the proposed approach lies in the ability to investigate both free and forced vibrations of empty and liquid-filled shells structures within the framework of the single computer technology. The benchmark test calculations demonstrated the high accuracy and efficiency of the proposed approach. The novelty and practical value of the obtained results lie in the ability to investigate fuel tanks of complex shapes under various conditions.
Stress-strain states of reinforced concrete spans of a railroad overpass using a spatial finite element model
Authors: Bondar Ivan Sergeevich , Aldekeyeva Dinara Tynyshbekovna , Ospanova Zere Kanatovna
Published: April 2024

The paper presents the results of computational analysis of the stress-strain state of reinforced concrete spans of the railway (single-track railway line) overpass over the highway, under specified loads using spatial finite element models. The static load consists of a cohesion of three TEM-18 diesel locomotives and two loaded gondola cars (up to 25 tons per axle). The purpose of this study was to ensure reliable and safe operation of artificial structures on the railroads, as there is a constant increase in transit freight trains from China through the territory of Kazakhstan to near and far abroad, and often the load on the axle reaches 25 tons, and sometimes larger values – up to 27 tons per axle. The results of the study are recommended to be used for inspections and tests of typical girder bridge spans, as well as in the case of monitoring their technical condition with increasing operational loads.
Design of 3-level LLC converter voltage controller for wide input voltage fluctuations
Authors: Lee Hyeong Jin , Kim Chan Ho , Kang Jeong Won , Kim Hag Wone
Published: April 2024

The auxiliary power supply unit for railway vehicles delivers various power to the passenger car. Maintaining isolation between the catenary power line and the auxiliary power in the compartment is typically essential. To ensure electrical isolation, an efficient LLC resonant converter is utilized among isolated DC-DC converters. Generally, LLC resonant converter primarily employ PFM control method. However, there is a limitation in increasing the switching frequency at high input voltages, making it difficult to handle wide input voltage fluctuations from the overhead catenary power line. To overcome this limitation, the PFM control method is introduced alongside the existing PFM control method, resulting in the presence of two controllers. However, since these two controllers regulate the output voltage differently, there is a potential for output voltage overshoot due to significant input voltage fluctuations. This paper proposes a method that combines PFM and PWM controllers, along with feed-forward compensation, to address these issues. The effectiveness of this proposed method is validated through PSIM simulation and experimentation.
What Makes Gen Z in Indonesia Use P2P Lending Applications: An Extension of Technology Acceptance Model
Authors: Yanto  , Putra Agung , Rahmani Zikri , Samsudin M. Afdal
Published: April 2024

This study aims to determine the factors influencing Gen Z members in Indonesia using P2P lending applications. This study extended TAM by collaborating with important constructs, such as trust, perceived risk, and hedonic motivation, to explain Generation Z’s intention to use P2P lending applications. This study utilized an online survey to acquire data. The total sample size was 305 users of P2P lending applications from Generation Z. The obtained data were then analyzed using PLS-SEM. The results show that perceived usefulness has no effect on the intention to use P2P lending applications. Meanwhile, trust mediates the relationship between perceived ease of use and perceived usefulness on intention to use P2P lending applications. The results show that Generation Z's intention to use P2P lending applications is influenced by technological sophistication factors, the belief that P2P lending applications guarantee their privacy concerns and security risks, and the existence of pleasant experiences.
Exploring Synthesis and Medicinal Applications of Andrographolide Derivatives: A
Review
Authors: Qadir Tanzeela , Shaikh Shoaib , Kanth Saadat A. , Singh Jyotika , Baby Maria , Sharma Praveen Kumar
Published: April 2024

Andrographolide, derived from the plant Andrographis paniculata (AP), exhibits
a diverse range of biological activities, encompassing anti-bacterial, anti-tumor, antiinflammatory,
anti-obesity, anti-viral, anti-fibrotic, hypoglycemic, and immunomodulatory
properties. Notably, numerous analogues of andrographolide have been synthesized, incorporating
significant chemical structural modifications to enhance bioavailability and druggability.
A comprehensive exploration into their molecular and cellular mechanisms of action
has also been undertaken, enriching our understanding. The investigation highlights the
potential of related terpenoid analogues from Andrographis paniculata, beyond the diterpene
lactone andrographolide, to hold promise in disease treatment due to structural similarities
and diverse pharmacological effects. This review offers insights into the anticipated
synthesis and therapeutic applications of andrographolide derivatives across a spectrum of disorders.
Genomics in Diabetic Kidney Disease: A 2024 Update
Authors: Roumeliotis Stefanos , Divani Maria , Stamellou Eleni , Liakopoulos Vassilios
Published: April 2024

Diabetic Kidney Disease (DKD) remains the leading cause of Chronic and End Stage
Kidney Disease (ESKD) worldwide, with an increasing epidemiological burden. However, still, the
disease awareness remains low, early diagnosis is difficult, and therapeutic management is ineffective.
These might be attributed to the fact that DKD is a highly heterogeneous disease, with disparities
and variability in clinical presentation and progression patterns. Besides environmental risk factors,
genetic studies have emerged as a novel and promising tool in the field of DKD. Three decades
ago, family studies first reported that inherited genetic factors might confer significant risk to DKD
development and progression. During the past decade, genome-wide association studies (GWASs)
screening the whole genome in large and multi-ethnic population-based cohorts identified genetic
risk variants associated with traits defining DKD in both type 1 and 2 diabetes. Herein, we aim to
summarize the existing data regarding the progress in the field of genomics in DKD, present how
the revolution of GWAS expanded our understanding of pathophysiologic disease mechanisms and
finally, suggest potential future directions.
Neuroprotective Efficacy of Phytoconstituents of Methanolic Shoots Extract of Calligonum polygonoides L. in Hypercholesterolemia-associated Neurodegenerations
Authors: Sakarwal Anita , Sen Karishma , Ram Heera , Chowdhury Suman , Kashyap Priya , Shukla Sunil Dutt , Panwar Anil
Published: April 2024

Background:

Small molecule phytocompounds can potentially ameliorate degenerative
changes in cerebral tissues. Thus, the current study aimed to evaluate the neuroprotective
efficacy of phytocompounds of methanolic shoots extract of Calligonum polygonoides L.
(MSECP) in hypercholesterolemia-associated neurodegenerations.

Methods:

Phytochemical screening of the extract was made by LCMS/MS and validated by a
repository of the chemical library. The hypercholesterolemia was induced through the intraperitoneal
administration of poloxamer-407 with a high-fat diet. The in-silico assessments were accomplished
by following the molecular docking, ADME and molecular dynamics. MMPBSA
and PCA (Principal Component Analysis) analyzed the molecular dynamics simulations. Consequently,
in-vivo studies were examined by lipid metabolism, free radical scavenging capabilities
and histopathology of brain tissues (cortex and hippocampus).

Results:

22 leading phytocompounds were exhibited in the test extract, as revealed by LCMS/
MS scrutiny. Molecular docking evaluated significant interactions of apigenin triacetate
with target proteins (HMGCR (HMG-CoA reductase), (AChE-Acetylcholinesterase) and
(BuChE- Butyrylcholinesterase). Molecular dynamics examined the interactions through assessments
of the radius of gyration, RSMD, RSMF and SASA at 100 ns, which were further
analyzed by MMPBSA (Molecular Mechanics Poisson-Boltzmann) and PCA (Principal Component
Analysis). Accordingly, the treatment of test extract caused significant alterations in lipid
profile, dyslipidemia indices, antioxidant levels and histopathology of brain tissues.

Conclusion:

It can be concluded that apigenin triacetate is a potent phytoconstituent of MSEPC
and can interact with HMGCR, AChE, and BuChE, which resulted in improved hypercholesterolemia
along with neuroprotective ameliorations in the cortex and hippocampus.
A Lenda da Maldição de Dona Teresa: Origens e Continuidade
Authors: Fontão Diana
Published: April 2024

The legend of Dona Teresa's curse is a historiographical episode whose earliest known version appears in the Primeira Crónica Portuguesa. This version and those that continue it in Iberian chronicles up to the Crónica de Portugal de 1419will be analyzed and compared in this article. Following that, the account of the Badajoz disaster, whose repercussions led to the creation of the legend of the curse of Dona Teresa, will also be studied
Trends Stability of Reliability Coefficient Based on Sample Size and Ability of Test-takers
Authors: Busnawir Busnawir , Kodirun Kodirun , Zamsir Zamsir , Samparadja Hafiludin , Hasnawati Hasnawati
Published: April 2024

One aspect that needs to be considered in the assessment of learning outcomes is the quality of the test by a stable reliability coefficient. This study aims to determine the trend of the stability of the reliability coefficient of the mathematics formative test based on the sample size and the ability of the test takers. The study was experimental in the form of a simulation, using a population of scores based on the answers of 403 test takers. The research sample was taken from the population of scores with 19 variations in sample sizes. Each sample size was repeated 31 times with the return technique; the reliability coefficient was calculated for each repetition and was used as the unit of analysis. In addition to the differences in sample sizes, the differences in the abilities of the test takers were also seen in two categories of high and low. Data were analyzed using exploratory-descriptive statistics and analysis of variance. Results showed as follows: first, the formative test of mathematics that was developed by the teacher at school has a reliability coefficient in the inadequate category; second, the reliability coefficient of the test tends to be more stable with increasing sample sizes; third, the difference in the ability of the test takers does not make a significant difference to the reliability coefficient; fourth, there is no interaction between sample sizes and abilities of the test takers on the reliability coefficient of the test.
AI Quality Standards in Health Care: Rapid Umbrella Review
Authors: Kuziemsky Craig E , Chrimes Dillon , Minshall Simon , Mannerow Michael , Lau Francis
Published: April 2024

Background

In recent years, there has been an upwelling of artificial intelligence (AI) studies in the health care literature. During this period, there has been an increasing number of proposed standards to evaluate the quality of health care AI studies.

Objective

This rapid umbrella review examines the use of AI quality standards in a sample of health care AI systematic review articles published over a 36-month period.

Methods

We used a modified version of the Joanna Briggs Institute umbrella review method. Our rapid approach was informed by the practical guide by Tricco and colleagues for conducting rapid reviews. Our search was focused on the MEDLINE database supplemented with Google Scholar. The inclusion criteria were English-language systematic reviews regardless of review type, with mention of AI and health in the abstract, published during a 36-month period. For the synthesis, we summarized the AI quality standards used and issues noted in these reviews drawing on a set of published health care AI standards, harmonized the terms used, and offered guidance to improve the quality of future health care AI studies.

Results

We selected 33 review articles published between 2020 and 2022 in our synthesis. The reviews covered a wide range of objectives, topics, settings, designs, and results. Over 60 AI approaches across different domains were identified with varying levels of detail spanning different AI life cycle stages, making comparisons difficult. Health care AI quality standards were applied in only 39% (13/33) of the reviews and in 14% (25/178) of the original studies from the reviews examined, mostly to appraise their methodological or reporting quality. Only a handful mentioned the transparency, explainability, trustworthiness, ethics, and privacy aspects. A total of 23 AI quality standard–related issues were identified in the reviews. There was a recognized need to standardize the planning, conduct, and reporting of health care AI studies and address their broader societal, ethical, and regulatory implications.

Conclusions

Despite the growing number of AI standards to assess the quality of health care AI studies, they are seldom applied in practice. With increasing desire to adopt AI in different health topics, domains, and settings, practitioners and researchers must stay abreast of and adapt to the evolving landscape of health care AI quality standards and apply these standards to improve the quality of their AI studies.
The Impact of Behavior Change Counseling Delivered via a Digital Health Tool Versus Routine Care Among Adolescents With Obesity: Pilot Randomized Feasibility Study
Authors: Kepper Maura , Walsh-Bailey Callie , Miller Zoe M , Zhao Min , Zucker Kianna , Gacad Angeline , Herrick Cynthia , White Neil H , Brownson Ross C , Foraker Randi E
Published: April 2024

Background

Youth overweight and obesity is a public health crisis and increases the risk of poor cardiovascular health (CVH) and chronic disease. Health care providers play a key role in weight management, yet few tools exist to support providers in delivering tailored evidence-based behavior change interventions to patients.

Objective

The goal of this pilot randomized feasibility study was to determine the feasibility of implementing the Patient-Centered Real-Time Intervention (PREVENT) tool in clinical settings, generate implementation data to inform scale-up, and gather preliminary effectiveness data.

Methods

A pilot randomized clinical trial was conducted to examine the feasibility, implementation, and preliminary impact of PREVENT on patient knowledge, motivation, behaviors, and CVH outcomes. The study took place in a multidisciplinary obesity management clinic at a children’s hospital within an academic medical center. A total of 36 patients aged 12 to 18 years were randomized to use PREVENT during their routine visit (n=18, 50%) or usual care control (n=18, 50%). PREVENT is a digital health tool designed for use by providers to engage patients in behavior change education and goal setting and provides resources to support change. Patient electronic health record and self-report behavior data were collected at baseline and 3 months after the intervention. Implementation data were collected via PREVENT, direct observation, surveys, and interviews. We conducted quantitative, qualitative, and mixed methods analyses to evaluate pretest-posttest patient changes and implementation data.

Results

PREVENT was feasible, acceptable, easy to understand, and helpful to patients. Although not statistically significant, only PREVENT patients increased their motivation to change their behaviors as well as their knowledge of ways to improve heart health and of resources. Compared to the control group, PREVENT patients significantly improved their overall CVH and blood pressure (P<.05).

Conclusions

Digital tools can support the delivery of behavior change counseling in clinical settings to increase knowledge and motivate patients to change their behaviors. An appropriately powered trial is necessary to determine the impact of PREVENT on CVH behaviors and outcomes.

Trial Registration

ClinicalTrials.gov NCT06121193; https://www.clinicaltrials.gov/study/NCT06121193
Develop a Mobile Health App to Enhance the Effectiveness of Bowel Preparation: Usability Study (Preprint)
Authors: Chen Hui-Yu , Tu Ming-Hsiang , Chen Miao-Yen
Published: April 2024

BACKGROUND

Colonoscopy is the standard diagnostic method for colorectal cancer. Patients usually receive written and verbal instructions for bowel preparation (BP) before the procedure. Failure to understand the importance of BP can lead to inadequate levels of over 25% to 30%. Quality of BP impacts the success of colonoscopy in diagnostic yield and adenoma detection.

OBJECTIVE

we developed the "ColonClean" mobile health (mHealth) application (app) for Android devices. It incorporates visual representations of dietary guidelines, steps for using bowel cleansing agents, and observations of the last bowel movement.

METHODS

We used the technology acceptance model (TAM) to investigate whether using the ColonClean mHealth app can enhance users' attitudes and behaviors towards BP. The study is aimed to investigate the correlation among perceived usefulness, perceived ease of use, attitude toward usage, and actual usage behavior. Forty outpatients who were physically and mentally healthy and proficient in Chinese were randomly chosen for this study. The data was analyzed using SPSS 25.0, with the utilization of Pearson Product-Moment Correlation and Simple Regression Analysis to predict the perception of ColonClean.

RESULTS

The results showed that 75% achieved an "excellent" or "good" level of BP according to the Aronchick Bowel Preparation Scale (ABPS). Perceived usefulness and perceived ease of use of the ColonClean mHealth app were positively correlated with users' attitudes and behaviors.

CONCLUSIONS

ColonClean mHealth app serves as an educational reference and enhances the effectiveness of BP. Users expressed their willingness to use the app again in the future and recommend it to family and friends, highlighting its effectiveness as an educational guide for BP.

CLINICALTRIAL

The study was approved by Taipei Veterans General Hospital Institutional Review Board (No.2021-10-007AC)
Numerical Study on the Effects of Helix Diameter and Spacing on the Helical Pile Axial Bearing Capacity in Cohesionless Soils
Authors: Pratama Ignatius Tommy , Lestari Anastasia Sri , Oktavianus Ivan
Published: April 2024

The methods employed to calculate the axial bearing capacity of a helical pile depends on the shear failure model around the pile, which is also influenced by the spacing and diameter of the helical plates. However, studies on the transition of the failure mode and the load transfer mechanism with the change of helical plate spacing and diameter in cohesionless soil subjected to axial compressive load have been limited. Thus, this paper investigated the effects of helix diameter and spacing on the axial compressive load-bearing capacity, shear failure model, and load transfer mechanism of helical piles with two helical plates embedded in the homogeneous medium and dense sands, as well as in the stratified medium to very dense sand. Axial loading tests on helical piles with various helix diameters and spacings were simulated using a two-dimensional finite element program with axisymmetric modeling to obtain the load-settlement curve, which was later used to estimate the ultimate bearing capacity of the helical piles. The ultimate bearing capacity of the helical piles was also computed using the conventional methods, i.e., the individual bearing and cylindrical shear methods, and then compared to the numerical-based axial bearing capacity. The stress-strain behaviors of pile and soil were modeled using the Linear Elastic and Mohr-Coulomb material models, respectively. The results show that the numerical-based ultimate bearing capacity of a helical pile increased with increasing the diameter and spacing of the helix. However, the ultimate bearing capacity computed using conventional methods did not show this trend. Then, the transition from the cylindrical shear to the individual bearing failure mechanism occurred at a spacing ratio (i.e., helical plate spacing divided by its diameter) of about two. Ultimately, the load transfer curves indicate that the helical plates mainly supported the applied load.
Strengthening Indian Land Governance: Enhancing Transparency through DPoS Blockchain Registry
Authors: Diwakar Ayush
Published: April 2024

Abstract: In India, where conventional Land Registry systems encounter challenges, Land Registry documents are crucial legal evidence of land ownership. Addressing these issues requires innovative solutions, and Blockchain technology offers a key solution.
The Digital Inclusion Challenges Among Rural Migrant Employees – A Phenomenological Study
Authors: R Mr. Balaji , Sabu Ms. Devikrishna
Published: April 2024

Abstract: The digital age demands proficiency in Information and Communication Technologies (ICTs) for economic success and social connection, especially in cities. However, young adults migrating from rural areas to Indian cities like Bengaluru often face digital exclusion. This study explores the challenges and psychological effects of this divide on young migrant employees (aged 21-25). Using interviews with 33 participants, the research identified key barriers: limited access to technology and the internet due to cost, lack of digital literacy skills, and anxieties around using unfamiliar tools. Furthermore, the study examined the psychological impact, drawing on theories of stress and coping (Lazarus & Folkman, 1984) and self-efficacy (Bandura, 1986). Digital exclusion can act as a stressor, leading to frustration, anxiety, and feelings of inadequacy. Low selfefficacy related to technology hinders motivation and perpetuates the cycle of exclusion. While acknowledging limitations in sampling, the research offers valuable insights into the experiences of young migrants. It highlights the psychological toll of digital exclusion and its impact on integration. These findings can inform policymakers and organizations to bridge the digital divide. Targeted interventions such as training programs, subsidized internet access, and user-friendly technology design can empower migrants and foster their success in the urban workforce
Customer Loyalty Program: Enhanced Rewards and Insights for Lasting Engagement
Authors: Bade Kranti
Published: April 2024

Abstract: Customer loyalty programs are strategic initiatives designed to cultivate and maintain strong relationships between businesses and their customers. These programs offer incentives and rewards to encourage repeat purchases and foster brand allegiance. By leveraging various techniques such as points systems, tiered memberships, or exclusive perks, companies aim to enhance customer satisfaction and retention. Effective loyalty programs not only drive revenue but also provide valuable data insights into consumer behaviour and preferences. In today's competitive landscape, cultivating customer loyalty is paramount for sustained success, and loyalty programs serve as powerful tools in building enduring connections with clients.
Predatory Monetization Schemes in Free-To-Play Mobile Game
Authors: Debnath Dr. Baisakhi
Published: April 2024

Abstract: Predatory monetization techniques in video games refer to payment methods that hide or delay the actual price of a game until after participants have invested financially and emotionally. to it. As gaming and gambling become more comparable, such programs raise the risk of financial harm for people who have Internet gaming disorder. A video game publisher may benefit from a specific video game product through a process known as video game monetization. Though game monetization tactics differ, especially when games are developed for many platforms or genres, the goal is usually the same: to recompense copyright holders, game designers, and other stakeholders.
The Startup Analysis Canvas: Smartfill RFID System
Authors: Kukreja Dr. Mansi , Menon Govind R , M Dhatchnesh , Raj Ashwal Emmanuel , A Subash , K Manoj Kumar , Madhu L
Published: April 2024

Abstract: In today's fast-paced world, convenience and efficiency are paramount, extending to mundane tasks like refueling vehicles. Traditional gas station payment methods involvingcash or credit cards can be cumbersome and time-consuming. Radio Frequency Identification (RFID) technology offers a promising solution to expedite gas station transactions, enhancing the customer experience. An RFID-based payment system leveragestags affixed to vehicles or issued as cards. Upon pulling up to an RFID-enabled pump, the reader automatically identifies the customer's vehicle or card, retrieving linked account information. The customer simply authorizes fueling, and the designated amount is seamlessly deducted from their account. This eliminates the need to exit the vehicle, searchfor wallets or cards, and swipe or insert them at the pump, significantly reducing transaction times. The benefits of an RFID-based payment system are manifold. First and foremost, it offers unparalleled convenience. Customers can streamline the fueling process without fumbling for cards or cash, leading to a more pleasant and time-efficient experience.Furthermore, RFID technology translates to shorter queues and improved customersatisfaction at gas stations. Reduced transaction times at pumps lead to faster throughput,benefiting both customers and gas station operators. Security is another significant advantage of RFID-based payments. Unlike traditional methods susceptible to fraud, RFID tags are tamper-proof and difficult to replicate. This significantly reduces the risk of unauthorized transactions and fraudulent activity, enhancing financial security for both customers and gas station businesses. Additionally, RFID technology offers potential for integration with loyalty programs. The system can be designed to automatically identify customers and credit their accounts with loyalty points based on their purchases. This fosters customer engagement and incentivizes repeat business, creating a win-win situation for both gas stations and their patrons. While RFID-based payment systems hold immense promise, there are challenges to consider. Implementation costs associated with equipping gas stations with RFID readers and potentially issuing tags to customers need to be carefully evaluated. Additionally, customer adoption is a crucial factor.Encouraging widespread acceptance of this new technology may require educational campaigns to highlight the benefits and dispel any misconceptions