bluuebunny/crossref_metadata_2025 huggingface dataset:
A cohort study of isolated brainstem infarction based on head MR imaging and clinical findings
Authors: Zhao Feng-li , Mi Dong-hua , Zhang Chang-qing , Song Qi-han , Liu Hong-shun , Dai Hai-lin , Liu Zhi-min , Ge Chang-qing , Wang Yong-jun , Liu Li-ping , Guo Li
Published: September 2018

Objective

The prognosis of patients with isolated brainstem infarction (BSI) differs on an individual patient basis. This study was undertaken to analyze the influences of different imaging and clinical features with the prognosis of patients with BSI.

Methods

The study population was derived from a multicenter study of intracranial atherosclerosis in China. In the present study, 300 patients were selected who had experienced non-cardiogenic brain stem infarction within the prior 7 days. Evaluations included clinical characteristics, location and size of the brainstem infarction, and whether the infarction was located in multiple perforating branches of the brainstem. Poor prognosis was defined as the presence of disability within 1 year from the onset of disease.

Results

In total, 281 patients were followed up at 1 year post-infarction. Of these 281 patients, 84 (29.9%) exhibited disability at 1 year; these patients showed a median National Institutes of Health Stroke Scale score of 6 on admission. Multiple logistic regression analysis showed that patients with BSI located in the territory of multiple perforating arteries, who were discharged without administration of statins, showed a poor 1-year prognosis.

Conclusion

Isolated BSI involving multiple perforating arteries, without statin medication at discharge, indicated poor prognosis for patients with BSI.
Tumor Thickness and Modified Clark Level in Canine Cutaneous Melanocytic Tumors
Authors: Silvestri Serenella , Porcellato Ilaria , Mechelli Luca , Menchetti Laura , Rapastella Sofia , Brachelente Chiara
Published: September 2018

Breslow thickness and Clark level are prognostic factors for human cutaneous melanomas. Breslow thickness is measured with an ocular micrometer from the top of the granular layer of the epidermis to the deepest invasive cell across the broad base of the tumor, while Clark level is based on the anatomical level of invasion through the layers of the dermis. Because of the anatomical differences between humans and dogs, we evaluated the tumor thickness and a modified Clark level in 77 canine primary cutaneous melanocytic tumors. Tumor thickness (using both a traditional and a more convenient system) and modified Clark level were measured and associated with histological diagnosis and clinical outcome. Tumor thickness was a prognostic factor, being greater in animals with shorter overall survival and disease-free time. Cutoffs of 0.95 cm and 0.75 cm defined a higher hazard for an unfavorable outcome and to develop recurrence/metastasis, respectively. Because of an excellent agreement between the 2 methods, it was concluded that tumor thickness could be measured with a ruler when an ocular micrometer is not available. Modified Clark level was not found to be relevant for prognosis. However, we suggest that both tumor thickness and a modified Clark level can be valid additional parameters when histological diagnosis is uncertain. Further studies, including a wider sample population, would be worthwhile to confirm the prognostic significance of these 2 parameters.
Lipid-Related Lesions in Quaker Parrots (Myiopsitta monachus)
Authors: Beaufrère Hugues , Reavill Drury , Heatley Jill , Susta Leonardo
Published: September 2018

The Quaker parrot has been used as a psittacine model to study clinical lipidology and lipid-related disorders. However, while Quaker parrots appear to be anecdotally susceptible to a variety of spontaneous dyslipidemic disorders and lesions caused by excess lipid accumulation, epidemiologic data are lacking. A multicenter retrospective study on 652 pathology submissions (411 necropsies and 243 biopsies) from Quaker parrots was performed by recording the final pathological diagnoses, age, and sex for each bird. The prevalence of lesions associated with lipid metabolism, such as hepatic lipidosis, atherosclerosis, xanthomas, adipose tumors, coelomic steatitis/steatonecrosis, endogenous lipid pneumonia, and acute pancreatic necrosis/pancreatitis, was reported. Multiple logistic regression models were used to characterize the effects of sex and age on these lesions, and the prevalence of hepatic lipidosis and atherosclerosis was compared to those in a random sample of control psittacine birds. The raw prevalence of atherosclerosis and hepatic lipidosis was 5.6% (95% confidence interval [CI], 3.4%–7.8%) and 21.2% (95% CI, 17.2%–25.1%), respectively. While the prevalence of atherosclerosis was similar to other psittacine species, hepatic lipidosis was more common in Quaker parrots. Quaker parrots also showed a unique susceptibility to acute pancreatic necrosis with a prevalence of 12.9% (95% CI, 9.7%–16.1%). Male parrots were found to be more susceptible than females to lipid accumulation lesions ( P = .0024), including atherosclerosis ( P = .018) and hepatic lipidosis ( P < .001). This retrospective study confirms the high susceptibility of Quaker parrots to lipid-related disorders and presents epidemiological data that may be useful to avian clinicians, pathologists, and researchers using Quaker parrots.
A survey into the experience of musically induced chills: Emotions, situations and music
Authors: Bannister Scott
Published: September 2018

Musically induced chills, an emotional response accompanied by gooseflesh, shivers and tingling sensations, are an intriguing aesthetic phenomenon. Although chills have been linked to musical features, personality traits and listening contexts, there exists no comprehensive study that surveys the general characteristics of chills, such as emotional qualities. Thus, the present research aimed to develop a broad understanding of the musical chills response, in terms of emotional characteristics, types of music and chill-inducing features, and listening contexts. Participants ( N = 375) completed a survey collecting qualitative responses regarding a specific experience of musical chills, with accompanying quantitative ratings of music qualia and underlying mechanisms. Participants could also describe two more “chills pieces”. Results indicate that chills are often experienced as a mixed and moving emotional state, and commonly occur in isolated listening contexts. Recurring musical features linked to chills include crescendos, the human voice, lyrics, and concepts such as unity and communion in the music. Findings are discussed in terms of theories regarding musical chills, and implications for future empirical testing of the response.
Geographic information science III: GIScience, fast and slow – Why faster geographic information is not always smarter
Authors: Miller Harvey J.
Published: September 2018

The growing maturity and deployment of low-cost georeferenced sensors, navigation systems, fast wireless communication, cyberinfrastructure and the Internet of Things (IoT) is accelerating the speed of geographic data flowing from the environment and our capabilities for reacting quickly to geographic information, often automatically and in real-time. This is leading to the rise of real-time GIS and smart cities technologies. While reacting quickly to changing circumstances has value, there are potentials for unintended consequences and rebound effects resulting from our inability to build geographic knowledge quickly and the selective acceleration of societal processes. This report discusses why these unintended outcomes may occur, and suggests technical and scientific approaches for understanding and managing the potential impacts of fast geographic data.
Consumer Finance and Labor Exploitation
Authors: Lattanzi-Silveus Luke
Published: September 2018

Lending to the working class is increasingly becoming an essential feature in modern capitalism. Marxist theory, however, does not possess an adequate account of this phenomenon, particularly its effect on labor exploitation. This paper seeks to show how Marxist economic theory could understand and account for this form of finance. It finds that lending to the working class enables increases in both absolute and relative surplus value.

JEL Classification: B51, G21, J50
Poly(vinyl alcohol) electrospun nanofibers containing antimicrobial Rhodomyrtus tomentosa extract
Authors: Zeyohanness Senait Sileshi , Abd Hamid Hazrulrizawati , Zulkifli Farah Hanani
Published: September 2018

Electrospun nanofibers were prepared from Rhodomyrtus tomentosa extract and poly(vinyl alcohol). The antimicrobial effect was assessed against two Gram-negative bacterial strains ( Escherichia coli, Pseudomonas aeruginosa) and two Gram-positive bacterial strains ( Bacillus subtilis, Enterococcus faecalis) by paper disc diffusion method. Ethyl acetate extract of R. tomentosa was selected for fabrication of nanofibers because it shows the most active antimicrobial activity with zone of inhibition ranging from 9.33 ± 0.21 to 13.67 ± 0.32 mm. The presence of high abundance of myricetin and rhodomyrtone might contribute to the antibiotic activity against all tested bacterial strains. The average diameter of the R. tomentosa extract/poly(vinyl alcohol) nanofibers increased from 120.4 to 214.8 nm with increasing concentration of R. tomentosa extract from 0.5% to 2.5%. The antimicrobial activity of R. tomentosa extract/poly(vinyl alcohol) nanofibers was relatively higher at concentration of the extract (1.5% and 2.5%) against all test organisms with a clear zone of inhibition 7–12 mm. The results demonstrated that R. tomentosa extract/poly(vinyl alcohol) electrospun nanofibers are an interesting platform for delivery of bioactive compounds as wound dressing or other strategies for combating bacterial infections.
Bronchoscope-Guided Percutaneous Endoscopic Gastrostomy Tube Placement by Interventional Pulmonologists: A Feasibility and Safety Study
Authors: Folch Erik , Kheir Fayez , Mahajan Amit , Alape Daniel , Ibrahim Omar , Shostak Eugene , Majid Adnan
Published: September 2018

Background:

Percutaneous endoscopic gastrostomy (PEG) tube placement is a procedure frequently done in the intensive care unit. The use of a traditional endoscope can be difficult in cases of esophageal stenosis and theoretically confers an increased risk of infection due to its complex architecture. We describe a technique using the bronchoscope, which allows navigation through stenotic esophageal lesions and also minimizes the risk of endoscopy-associated infections.

Methods:

Prospective series of patients who had PEG tube placement guided by a bronchoscope. Procedural outcomes including successful placement, duration of the entire procedure, time needed for passage of the bronchoscope from the oropharynx to the major curvature, PEG tube removal rate, and mortality were collected. Procedural adverse events, including infections and long-term PEG-related complications, were recorded.

Results:

A total of 84 patients underwent bronchoscope-guided PEG tube placement. Percutaneous endoscopic gastrostomy tube insertion was completed successfully in 82 (97.6%) patients. Percutaneous endoscopic gastrostomy tube placement was performed immediately following percutaneous tracheostomy in 82.1%. Thirty-day mortality and 1-year mortality were 11.9% and 31%, respectively. Overall, minor complications occurred in 2.4% of patients, while there were no major complications. No serious infectious complications were identified and no endoscope-associated hospital acquired infections were documented.

Conclusions:

The use of the bronchoscope can be safely and effectively used for PEG tube placement. The use of bronchoscope rather than a gastroscope has several advantages, which include the ease of navigating through complex aerodigestive disorders such as strictures and fistulas as well as decreased health-care utilization. In addition, it may have a theoretical advantage of minimizing infections related to complex endoscopes.
Evaluation of the Use of Low-Dose 4-Factor Prothrombin Complex Concentrate in the Reversal of Direct Oral Anticoagulants in Bleeding Patients
Authors: Allison Teresa A. , Lin Pei Jen , Gass Jennifer A. , Chong Kenneth , Prater Samuel J. , Escobar Miguel A. , Hartman Heather D.
Published: September 2018

Objective:

This study investigated the percentage of patients who achieved hemostasis with 4-factor prothrombin complex concentrate (4-factor PCC) 35 U/kg. The primary end point was to determine the effect of 4-factor PCC 35 U/kg on bleeding progression, assessed using computed tomography.

Methods:

This was a retrospective, observational, single-center study conducted in patients with a major bleed admitted to a level 1 trauma center from May 1, 2013, to June 15, 2015, who received 4-factor PCC 35 U/kg for reversal of a direct factor Xa inhibitor taken prior to admission.

Results:

Thirty-three patients were included in the study, with 31 patients in the final analysis. The mean (standard deviation) age was 73 (14.8) years; 54.5% of patients were female. Of the 33 patients, 13 presented with a traumatic brain injury, 9 with an aneurysmal subarachnoid hemorrhage, 8 with an intracerebral hemorrhage, 1 with a gastrointestinal bleed, 1 with a hematoma with active extravasation, and 1 with an intra-abdominal bleed. The most frequently used direct factor Xa inhibitor was rivaroxaban (81.8%). Overall, 83.8% of patients achieved hemostasis with 4-factor PCC 35 U/kg. Progression of hemorrhage was observed in 4 patients on repeat computed tomography scan and 1 patient had continued surgical bleeding. No thromboembolic events were reported.

Conclusions:

Low-dose, 4-factor PCC 35 U/kg appeared to produce hemostasis in a majority of the patients. This may be an effective dosing regimen for anticoagulant reversal of factor Xa inhibitors in clinically bleeding patients.
Multidimensional Care Burden in Parkinson-Related Dementia
Authors: Vatter Sabina , McDonald Kathryn R. , Stanmore Emma , Clare Linda , Leroi Iracema
Published: September 2018

Background and Objective:

Providing care to people with Parkinson-related dementia (PwPRD) may result in significant stress, strain, and burden for life partners. A common measurement of life partner burden is the Zarit Burden Interview (ZBI), which considers “burden” as a unitary concept; however, burden is highly complex and most likely comprises several dimensions. This study aimed to explore the factor structure of the ZBI in life partners of PwPRD and to examine the relationships among the emerging factors and the demographic and clinical features.

Methods:

Life partners of PwPRD participated in home-based quantitative assessments and self-completed postal questionnaires. The assessment battery included ZBI, measures of relationship satisfaction, mood, stress, resilience, health, quality of life, feelings related to care provision, and sociodemographic questions. Data on PwPRDs’ motor and neuropsychiatric symptom severity were also elicited in home-based assessments.

Results:

An exploratory factor analysis (principal axis factoring) of ZBI, conducted with 127 life partners, revealed five burden dimensions: social and psychological constraints, personal strain, interference with personal life, concerns about future, and guilt. These burden factors were associated with lower relationship satisfaction, mental health, and resilience, and higher stress, anxiety, depression, resentment, negative strain, and PwPRD motor severity. In multiple linear regression analyses, where each factor score was the dependent variable, stress, negative strain, and resentment emerged as significant predictors of specific burden dimensions.

Conclusions:

Burden is a complex and multidimensional construct. Interventions should address specific types of burden among life partners of PwPRD to support couples’ relationships and maintain quality of life.
Gender, race, faith and economics
Authors: Elton-Chalcraft Sally , Kendrick Ann , Chapman Alison
Published: September 2018

This article explores factors inhibiting or encouraging women and men from Black and Minority ethnic (BME) and also white backgrounds to pursue leadership positions in English schools. Data are drawn from a commissioned evaluation of three National College of Teaching and Leadership (NCTL)-funded courses which investigated the extent to which the 33 participants felt their course successfully prepared them to take on a leadership role. Findings showed that although primary aspirant head teachers and most women into secondary headship gained confidence and felt more competent as their courses progressed, their desire to become leaders, in some cases, decreased. The opposite was the case for the BME participants, most of whom cited, along with increased confidence and perceived competence, an increased desire to become middle leaders, despite some accounts of prejudicial treatment. Factors cited by participants as impacting negatively on their desire to become leaders included work–life balance, accountability, faith, economic factors (size of school, travel costs) and issues concerning gender, particularly for women participants, who saw themselves as leaders both at work and in the home. Findings provide an insight into the continuing structural inequalities experienced by a small sample of aspirant school leaders which have implications for future leadership preparation provision.
The Fearful and Anxious Professional: Partner Experiences of Working in the Financialized Professional Services Firm
Authors: Allan Scott M , Faulconbridge James R , Thomas Pete
Published: September 2018

This article explores the work and career of law firm partners in the context of a financialized organizational regime, highlighting the effects of performance measures and metrics on the ways partners see themselves and their careers. The empirical analysis reveals a sense of fear and anxiety as partners experience the scrutiny and pressure of financialized performance management. Furthermore, it reveals partners face contradictory demands as they are pushed to meet financial and ‘citizen’ objectives within the firm. The result is a career as a ‘project of the self’ that relies on various protection strategies and which results in professionals captured by ‘financialization’ and unable to assimilate its demands in ways that protect traditional professional values.
Retention and attrition among National Certificate (Vocational) Civil and Construction students in South African TVET
Authors: Van der Bijl Andre , Lawrence Mark
Published: September 2018

The National Certificate (Vocational) (NC(V)) was introduced into South Africa’s system of vocational training to ‘solve problems of poor quality programmes, lack of relevance to the economy, as well as low technical and cognitive skills of TVET [technical and vocational education and training] graduates’. The NC(V) did not, however, meet expectations, partially because of systemic difficulties. This article reports on research conducted among students who studied on the NC(V) Civil and Construction programme in an effort to identify appropriate corrections that could be made by college management. The research project made use of Tinto’s Student Integration Model to identify reasons for both student attrition and student persistence. The study provides information on the predicament facing TVET Civil and Construction students and has broad relevance for practitioners operating in higher and post-school education.
Study on the influence of machine tool spindle radial error motion resulted from bearing outer ring tilting assembly
Authors: Li Xiaohu , Yan Ke , Lv Yifa , Yan Bei , Dong Lei , Hong Jun
Published: September 2018

To reveal the spindle radial error motion characteristics in condition of bearing outer ring tilting assembly, mathematical method on spindle radial error motion were analyzed. Then, in real operation condition the natural frequency of the test rig was investigated. Experimental system and methods were designed to test axial thermal displacement, radial error motion and modal characteristic of spindle in condition of bearing outer ring tilting assembly. Results show that axial thermal extension and radial vertical rising of spindle front-end occurs during thermal displacement test. With the same outer spacer nonparallelism, the synchronous error motion and total error motion generally increase with spindle rotation speed, and reach a peak at certain rotation speed.
Lessons from CODI on co-production
Authors: Boonyabancha Somsook , Kerr Thomas
Published: September 2018

Somsook Boonyabancha, former director of CODI (the Community Organizations Development Institute in Thailand) and now an advisor to the CODI board and chairperson of the Baan Mankong Program Committee, reflects on the evolution of CODI, the management of its fund, and the community-driven activities it has supported since 1992. The paper explains how substantial and large-scale changes can be brought about in the lives of the poor by supporting a community-driven process that opens space for negotiation and collaboration with government and other partners on housing and other aspects of community development. It describes the transitions that have had to be managed, as both the community networks and the support institution have navigated various challenges and opportunities. A centrepiece of this co-production is the Baan Mankong Program, which represents a dramatic change in the role of government – from a provider of housing to facilitator of community-driven local housing co-production.
Exploring the Mediating Role of Employee Attitudes in the Relationship between High-Performance Work Systems and Turnover Intention among IT Professionals in India: A Serial Mediation Approach
Authors: Ramaprasad Badrinarayan Srirangam , Lakshminarayanan Sethumadhavan , Pai Yogesh P.
Published: September 2018

The primary purpose of this study was to seek an answer to the question of ‘how’ do high-performance work systems (HPWSs) relate to turnover intention (TI) among information technology (IT) professionals in the Indian IT sector. Against the backdrop of this purpose, we examined, by using multiple regression analysis and a serial mediation approach, the intervening effects that the constructs of work engagement (WE) and organizational commitment (OC) exercised, sequentially, on the relationship between HPWS and TI among 752 IT professionals spread across 17 Indian IT organizations. The findings of this study reveal that the relationship between HPWS and employees’ TI is entirely indirect; that is, WE and OC, in that order, fully and serially mediate the relationship between HPWS and employees’ TI. Further, the study offers a strong case for practitioners from the Indian IT sector to adopt a robust and a synergetic HPWS in order to elicit favourable employee attitudes and consequently mitigate the employees’ TI.
The financialization of the state: Government debt management reforms in New Zealand and Ireland
Authors: Trampusch Christine
Published: September 2018

The financialization of sovereign debt management has received attention in comparative political economy studies. While previous studies have highlighted the cross-national commonality of this process and the congruence of interests between finance and governments, the analysis of the role of finance and state agency in domestic reform processes is still under-exposed. By analysing the financialization of government debt management in the two early adopter countries, New Zealand and Ireland, this study seeks to close this gap. The study shows that differences in the structure of financial markets and the civil service systems resulted in different policymaking processes through which Treasury civil servants brought financial economics into the reforms. In New Zealand, economists had an in-house position within the Treasury and were able to frame the decision-making process (ideational explanation), while in Ireland, finance successfully lobbied senior civil servants who sponsored these efforts (interest explanation). With this finding, this article reveals the multiple channels that lead to sovereign debt management financialization.
A capability approach to career development: An introduction and implications for practice
Authors: Robertson Peter J , Egdell Valerie
Published: September 2018

In the UK, the concept of employability is influential in current conceptualizations of career development. It is an example of a discourse underpinned by faith in individual transformation as a response to unstable labour markets, a position that is not unproblematic when structural factors are taken into account. This article introduces an alternative perspective, the capability approach, to encourage debate about its value, and to begin to outline what it means for career counselling and development practice. An overview of the capability approach is provided, and the resonance between the concerns of the capability approach and those of career development practitioners will be highlighted. Key difficulties in applying the approach are identified before implications of the capability approach for practice are considered.
Dialogic Reading and Adapted Dialogic Reading With Preschoolers With Autism Spectrum Disorder
Authors: Grygas Coogle Christan , Floyd Kimberly K. , Rahn Naomi L.
Published: September 2018

An adapted alternating treatments design, replicated across two books, was used to examine the effects of Dialogic Reading delivered using traditional paperback books and technology-enhanced books utilizing a Surface tablet on the vocabulary acquisition of four preschoolers with autism spectrum disorder. For each book, 30 words were randomly assigned to conditions (i.e., 10 to traditional Dialogic Reading, 10 to Dialogic Reading with technology, 10 to control). Intervention was delivered 1 to 4 times per week across 6 months. Results suggest both methods increased vocabulary compared with baseline. Dialogic Reading delivered via both paperback and technology-enhanced books is promising for increasing vocabulary for preschoolers with autism spectrum disorder.
Anticoagulation for the Treatment of Cancer-Associated Thrombosis: A Systematic Review and Network Meta-Analysis of Randomized Trials
Authors: Sobieraj Diana M. , Baker William L. , Smith Eni , Sasiela Katarzyna , Trexler Stephanie E. , Kim Oliver , Coleman Craig I.
Published: September 2018

To perform a systematic review and network meta-analysis evaluating the efficacy and safety of low-molecular-weight heparins (LMWHs), vitamin K antagonists (VKAs), and direct-acting oral anticoagulants (DOACs) for the treatment of cancer-associated thrombosis (CAT). We searched MEDLINE, Cochrane Central Register of Controlled Trials, and conference abstracts through March 2018. Randomized controlled trials (RCTs) enrolling adults with CAT comparing 2 or more full-dose anticoagulants (LMWH, VKA, and DOAC) and evaluating recurrent venous thromboembolism (VTE), major bleeding, and/or all-cause mortality were included. Reviewers identified studies, extracted data, and assessed the quality of the evidence in duplicate. A frequentist network meta-analysis, which uses direct and indirect evidence to simultaneously compare multiple interventions, was performed using a random-effects approach. Results are reported as pooled relative risks (RRs) with 95% confidence intervals (CIs). We included 13 RCTs (n = 6292): 7 compared LMWHs with VKAs, 4 compared DOACs with VKAs, and 2 compared DOACs with LMWHs. The risk of recurrent VTE was significantly reduced by 28% and 54% with a DOAC compared to an LMWH and a VKA, respectively. Low-molecular-weight heparins significantly reduced the risk of recurrent VTE by 36% versus VKAs. The risk of major bleeding was 14% higher with DOACs compared to LMWHs and 15% and 25% lower with DOACs and LMWHs versus VKAs, although 95% CIs included unity for each. The risk of all-cause mortality appeared similar for all 3 comparisons (RR = 1.0 for each comparison). Direct-acting oral anticoagulants appeared superior in reducing recurrent VTE in patients with CAT compared to LMWH and VKAs, but an increased risk of major bleeding versus LMWH cannot be ruled out.
Reference values of pattern reversal visual evoked potentials in Bulgarian population
Authors: Mermeklieva Elena A
Published: September 2018

Aims:

The aim of this study is to evaluate pattern visual evoked potentials as an objective electrophysiological method and to create reference values for Bulgarian population.

Methods and Materials:

Standardized four-channel equipment ‘Neuro-MEP 4’ produced by ‘Neurosoft’ Company was used. A group of 47 healthy individuals (94 eyes) was studied. The stimulation was monocular, with a contrast-reversing pattern from black to white and vice versa. The investigation was performed with a three-channel recording with equipment adjustments according to the latest published ISCEV standard for pattern visual evoked potentials (2016). Based on a comprehensive overview of the available literature, a protocol of stimulating, amplifying and recording the obtained potentials has been created. The values of pattern visual evoked potential wave components, P50, N75, P100, N145 and P200, were measured.

Results:

Based on a created protocol, latency and amplitudes of the individual wave components of pattern visual evoked potentials were obtained. The results were statistically processed to create reference values of all pattern visual evoked potentials components, which are used as reference of the laboratory for the Bulgarian population.

Conclusion:

Pattern visual evoked potentials are objective electrophysiological method which is used to diagnose and monitor numerous ophthalmological and neurological diseases as well as for objective study of visual acuity and visual field in children and aggravation. The creation of pattern visual evoked potentials reference values for the Bulgarian population and its implementation in clinical practice are of particular importance for studying the visual analyser function.
Translating Inclusion
Authors: Arp Fallov Mia , Hoffmann Birk Rasmus
Published: September 2018

The purpose of this article is to explore how practices of translation shape particular paths of inclusion for people living in marginalized residential areas in Denmark. Inclusion, we argue, is not an end-state but rather something that must be constantly performed. Active citizenship, today, is not merely a question of participation but also learning to become active in all spheres of life. The article draws on empirical examples from a multisite fieldwork in six different sites of local community work in Denmark, to demonstrate how different dimensions of translation are involved in shaping active citizenship. We propose the following different dimensions of translation: translating authority, translating language, and translating social problems. The article takes its theoretical point of departure from assemblage urbanism, arguing that cities are heterogeneous assemblages of sociomaterial interactions. Through the practices of translation, local community work both transforms the possibilities for residents and disrupts the compositions of urban assemblages. Through this, we argue, local community work creates new opportunities for residents.
Power and Counter-Power: Knowledge Structure and the Limits of Control
Authors: David Matthew , Meersohn Schmidt Cynthia
Published: September 2018

In this article, we explore Susan Strange’s multidimensional and non-reductive international political economy (IPE) approach to structural power. Strange’s key weakness is the failure to account for her knowledge structure’s regulative form relative to her security, production and financial structures. We seek to develop Strange’s account through the addition of Manuel Castells’ account of digital network structures. Castells’ morphogenic structural approach to digital network power helps to clarify the mechanisms by which today’s knowledge structure achieves autonomy, internal regulation and generative capacity. This sociological completion of Strange’s theory, an international socio-political economy approach as it were, better explains the capacity and limits of today’s digital network knowledge structure to resist reduction to other structural interests. Strange’s non-reductive structural approach to power is significant for sociology as it helps identify ‘social order’ in a global age, but an additional sociological dimension is also necessary for the fulfilment of Strange’s theoretical project.
Technologies of public culture: Heritage encounters with photography, television and the web
Authors: Stainforth Elizabeth , Baeza Ruiz Ana
Published: September 2018

The operations through which cultural heritage institutions perform their civic and governmental roles have been identified with a logic of visual apprehension by writers such as Tony Bennett. This article explores how these institutions have ordered and regulated contact with their publics via a negotiation of different visual communication technologies, specifically, photography, television and the web. Through analysis of individual cases, it is possible to discern the shifting relationship between public heritage institutions and their audiences, as mediated by these technologies. It is argued that this approach develops a distinctive understanding of public culture and demonstrates the ways in which notions of publicness shape and are shaped by visual communication technologies in the cultural heritage context.
Investment in Physical, Human Capital, Economic Growth and Life Expectancy in Bangladesh
Authors: Maitra Biswajit
Published: September 2018

This article studies the efficacy of the public investment in human capital and physical capital to raise income in Bangladesh over the period 1980–2016. This article also assesses whether the investment in human capital and income have raised life expectancy of the country. The Johansen cointegration test identifies a long-run relation of income with investment on education, health care and physical capital. The error correction mechanism (ECM) based on the cointegrating relation followed by the Wald test of Granger causality has found that these investments have caused income to rise with some lag periods. Robustness of these findings is confirmed by involving an autoregressive distributed lag (ARDL) model of cointegration followed by its ECM representation. On the other hand, the Johansen and ARDL methods of cointegration followed by their ECMs have also found a long-run relation of life expectancy with the investment in education, health care and income. A decisive role of the investment in health care and income on life expectancy is observed, while an unusual negative role of the investment in education is also found. However, positive value of the long-run coefficients of the education and health-care investments of the ECM-ARDL model indicate some long-run favourable impact of these investments on life expectancy in Bangladesh.

JEL: I26, I15, C32
Fake images: The effects of source, intermediary, and digital media literacy on contextual assessment of image credibility online
Authors: Shen Cuihua , Kasra Mona , Pan Wenjing , Bassett Grace A , Malloch Yining , O’Brien James F
Published: September 2018

Fake or manipulated images propagated through the Web and social media have the capacity to deceive, emotionally distress, and influence public opinions and actions. Yet few studies have examined how individuals evaluate the authenticity of images that accompany online stories. This article details a 6-batch large-scale online experiment using Amazon Mechanical Turk that probes how people evaluate image credibility across online platforms. In each batch, participants were randomly assigned to 1 of 28 news-source mockups featuring a forged image, and they evaluated the credibility of the images based on several features. We found that participants’ Internet skills, photo-editing experience, and social media use were significant predictors of image credibility evaluation, while most social and heuristic cues of online credibility (e.g. source trustworthiness, bandwagon, intermediary trustworthiness) had no significant impact. Viewers’ attitude toward a depicted issue also positively influenced their credibility evaluation.
Efficacy of Percutaneous Thermal Ablation Combined With Transarterial Embolization for Recurrent Hepatocellular Carcinoma After Hepatectomy and a Prognostic Nomogram to Predict Survival
Authors: Yuan Zhuhui , Wang Yang , Hu Caixia , Gao Wenfeng , Zheng Jiasheng , Li Wei
Published: September 2018

Aim:

This study aimed to evaluate the efficacy of percutaneous thermal ablation combined with transarterial embolization for recurrent hepatocellular carcinoma after hepatectomy and establish a prognostic nomogram to predict survival.

Methods:

One hundred seventeen patients with recurrent hepatocellular carcinoma receiving ablation from 2009 to 2014 were included in primary cohort to establish a prognostic nomogram. Between 2014 and 2016, 51 patients with recurrent hepatocellular carcinoma treated by ablation were enrolled in the validation cohort to validate the predictive accuracy of the nomogram. All patients underwent locoregional ablation. Overall survival was the primary end point, and progression-free survival was the second end point. The performance of the nomogram was assessed through concordance index and calibration curve and compared with 5 conventional hepatocellular carcinoma staging systems.

Results:

The 1-, 3-, and 5-year overall survival rates of primary cohort were 88.4%, 70.7%, and 64.1%, respectively. The 1-, 3-, and 5-year progression-free survival rates of primary cohort were 44%, 14%, and 8.7%, respectively. The results of multivariate analysis showed that tumor size ( P = .0469; hazard ratio, 1.020; 95% confidence interval, 1.0004-1.040), preoperative extrahepatic disease ( P = .0675; hazard ratio, 2.604; 95% confidence interval, 0.933-7.264), and close to hepatic hilum <2 cm ( P = .0053; hazard ratio, 3.691; 95% confidence interval, 1.474-9.240) were predictive factors for overall survival. The study established a nomogram to predict survival (concordance index, 0.752; 95% confidence interval, 0.656-0.849). According to the predicted overall survival, patients with recurrent hepatocellular carcinoma were divided into 3 risk classes ( P < .05): low-risk group (total score <55; predicted 5-year overall survival rate, 82.9%), intermediate-risk group (55 ≤ total score < 99; predicted 5-year overall survival rate, 52.8%), and high-risk group (hazard ratio, total score ≥99; predicted 5-year overall survival rate, not available).

Conclusion:

Percutaneous thermal ablation appears to be an effective procedure for the treatment of recurrent hepatocellular carcinoma after hepatectomy. The proposed nomogram provides a mechanism to accurately predict survival and could stratify risk among patients with recurrent hepatocellular carcinoma treated by ablation therapy.
The Study of MDM2 rs937283 Variant and Cancer Susceptibility in a Central Chinese Population
Authors: Chen Bifeng , Wang Jingdong , Wang Jieling , Zhang Jingli , Gu Xiuli , Feng Xianhong
Published: September 2018

The rs937283 variant, locating in murine double minute 2 promoter region, has been previously reported to potentially alter the promoter activity and to influence cancer susceptibility. In this study, we investigated the association of murine double minute 2 rs937283 variant and cancer susceptibility in a central Chinese population, followed by a meta-analysis. A total of 1058 healthy controls, 480 patients with breast cancer, 384 patients with cervical cancer, 480 patients with liver cancer, 426 patients with colon cancer, and 361 patients with rectal cancer were recruited in this case–control study. The murine double minute 2 rs937283 was genotyped by polymerase chain reaction restriction fragment length polymorphism and confirmed by sequencing. Our case–control analysis revealed that rs937283 was associated with the susceptibility to breast and liver cancer, but not cervical, colon, or rectal cancer. Specifically, the G allele of rs937283 conferred a significantly increased risk of breast and liver cancer. Moreover, results of meta-analysis demonstrated that rs937283 was significantly associated with cancer susceptibility, and this significant association remained in Asian (Chinese) population, but not in Caucasian population. Collectively, the murine double minute 2 rs937283 variant may serve as a potential biomarker for cancer predisposition in Chinese population.
Liquid Biopsy Promotes Non-Small Cell Lung Cancer Precision Therapy
Authors: Lu Jun , Han Baohui
Published: September 2018

The range of potential applications of liquid biopsies for non-small cell lung cancer management is expanded by the use of circulating tumor deoxyribonucleic acid and circulating tumor cells. Principal studies have demonstrated the predictive accuracy of droplet digital polymerase chain reaction detection, next-generation sequencing, and circulating tumor cells detection in patients with non-small cell lung cancer. The translational potential of these liquid biopsy technologies promotes the improvement of sensitivity and specificity in genomic and molecular methods. Here, we highlight the realities and challenges associated with the use of liquid biopsies for the detection of non-small cell lung cancer in patients. However, liquid biopsy technologies including circulating tumor cells detection, droplet digital polymerase chain reaction detection, and next-generation sequencing detection for precision therapy in non-small cell lung cancer will show substantive clinical applications in the future.
Caffeic Acid Versus Caffeic Acid Phenethyl Ester in the Treatment of Breast Cancer MCF-7 Cells: Migration Rate Inhibition
Authors: Kabała-Dzik Agata , Rzepecka-Stojko Anna , Kubina Robert , Wojtyczka Robert Dariusz , Buszman Ewa , Stojko Jerzy
Published: September 2018

Epithelium mammary carcinoma is a cancer with a high death rate among women. One factor having a significant impact on metastasis is cell migration. The aim of this study was to compare migration rate inhibition of caffeic acid (CA) and its phenethyl ester (CAPE) on MCF-7 breast cancer cells. Microscopic evaluation was used to determine the morphology of carcinoma cells, before and after 24-hour treatment with CA and CAPE using a dose of 50 µM. The cytotoxic effect was measured by XTT-NR-SRB assay (tetrazolium hydroxide-neutral red-Sulforhodamine B) for 24-hour and 48-hour periods, using CA and CAPE, with doses of 50 and 100 µM. These doses were used to determine cell migration inhibition using a wound closure assay for 0-hour, 8-hour, 16-hour, and 24-hour periods. Both CA and CAPE treatments displayed cytotoxic activity in a dose- and time-dependent trend. CAPE displayed IC50 values more than twice as low as CA. IC50 values for the XTT assay were as follows: CA was 102.98 µM for 24 hours and 59.12 µM for 48 hours, while CAPE was 56.39 µM for 24 hours and 28.10 µM for 48 hours. For the NR assay: CA was 84.87 µM at 24 hours and 65.05 µM at 48 hours, while CAPE was 69.05 µM at 24 hours and 29.05 µM at 48 hours. For the SRB assay: At 24 hours, CA was 83.47 µM and 53.46 µM at 48 hours, while CAPE was 38.53 µM at 24 hours and 20.15 µM at 48 hours. Both polyphenols induced migration inhibition, resulting in practically halting the wound closure. CAPE produced better results than CA with the same doses and experiment times, though both CA and CAPE displayed cytotoxic activity against MCF-7 cells, as well as inhibited migration.
Alterations of MicroRNA Expression in the Liver, Heart, and Testis of Mice Upon Exposure to Repeated Low-Dose Radiation
Authors: Liang Xinyue , Zheng Shirong , Cui Jiuwei , Yu Dehai , Yang Guozi , Zhou Lei , Wang Brain , Cai Lu , Li Wei
Published: September 2018

MicroRNAs (miRs), which regulate target gene expression at the post-transcriptional level, play a crucial role in inducing biological effects upon high-dose ionizing radiation. Yet, the miR expression profiles in response to repeated low-dose radiation (LDR) in vivo have not been elucidated. This study investigated the response profiles of 11 miRs with functions involved in metabolism, DNA damage and repair, inflammation, and fibrosis in mouse liver, heart, and testis upon repeated LDR exposure for 4 months. The expression profiles were evaluated using stem-loop quantitative reverse transcription polymerase chain reaction immediately and at 2 months after LDR exposure. The expression profiles varied significantly at both time points. At the organ level, the heart was the most affected, followed by the liver and testis, in which significant miR upregulation related to DNA damage response was found. Metabolism-related miRs decreased in the liver and increased in the testis. The current results showed immediate and long-lasting alterations in the miR expression profiles in response to repeated LDR in different organs.
Intestinal dysbacteriosis activates tumor-associated macrophages to promote epithelial-mesenchymal transition of colorectal cancer
Authors: Wan Guangsheng , Xie Manli , Yu Hongjie , Chen Hongyu
Published: September 2018

In this study we investigated the association between intestinal dysbacteriosis with colorectal cancer progress and the underlying molecular mechanisms. Tumor progression was evaluated using xenograft mice model. The epithelial-mesenchymal transition (EMT) markers were quantified by both real-time PCR and immunoblotting. The serum content of IL-6 and TNF-α were measured with ELISA kits. Cell proliferation was determined by the Cell Counting Kit-8. Intestinal dysbacteriosis was successfully simulated by the administration of a large dose of antibiotics and was demonstrated to promote xenograft tumor growth and induce EMT. Accordingly, the serum concentrations of cytokines IL-6 and TNF-α were significantly increased. Furthermore, the production and secretion of IL-6 and TNF-α were remarkably elevated in macrophages isolated from intestinal dysbiotic mice in comparison with the normal counterparts, and conditioned medium from these was shown to significantly stimulate EMT process in HT29 cells in vitro. Macrophage depletion completely abrogated the pro-tumor effect of intestinal dysbacteriosis. Our results suggest that intestinal dysbacteriosis stimulates macrophage activation and subsequently induces EMT process via secreted pro-inflammatory cytokines IL-6 and TNF-α.