bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure S4 from Complete Remissions of HER2-Positive Trastuzumab-Resistant Xenografts Using a Potent [225Ac]Ac-Labeled Anti-HER2 Antibody–Drug Radioconjugate
Authors: Pougoue Ketchemen Jessica , Njotu Fabrice Ngoh , Babeker Hanan , Monzer Alissar , Nwangele Emmanuel , Tikum Anjong Florence , Henning Nikita , Hassani Nava , Frye Sarah , Perron Randy , Byrne Chris , Didychuk Candice , Qi Qi , Bannister Laura , Doroudi Alireza , Fonge Humphrey
Published: February 2025

Supplementary Fig. S4: Internalization of immunoconjugates into the lysosomes and endosomes. (A) In HCC1954 and JIMT-1 cell lines, rapid time-dependent increase in red fluorescence for trastuzumab and respective conjugates was observed from 2 hours (h) to 48 hours. Experiments were done in triplicate. (B) Representative phase contrast images of HCC1954 and JIMT-1 with constructs
Supplementary Figure S1 from Complete Remissions of HER2-Positive Trastuzumab-Resistant Xenografts Using a Potent [225Ac]Ac-Labeled Anti-HER2 Antibody–Drug Radioconjugate
Authors: Pougoue Ketchemen Jessica , Njotu Fabrice Ngoh , Babeker Hanan , Monzer Alissar , Nwangele Emmanuel , Tikum Anjong Florence , Henning Nikita , Hassani Nava , Frye Sarah , Perron Randy , Byrne Chris , Didychuk Candice , Qi Qi , Bannister Laura , Doroudi Alireza , Fonge Humphrey
Published: February 2025

Supplementary Fig. S1: MALDI-TOF- matrix-assisted laser desorption ionization-time of flight mass spectrometry of trastuzumab, T-PEG6-DM1, and macropa-T-PEG6-DM1 was used to determine the drug-to-antibody ratio (DAR) and the chelator-to-antibody ratio (CAR) for Macropa.
Supplementary Table S3 from Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L.
Published: February 2025

Supplementary Table S3. Clinical information for validation cohort of melanoma brain metastases.
Supplementary Table 8 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 8
Supplementary Table 7 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 7
Supplementary Table 3 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 3
Supplementary Table 2 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 2
Supplementary Table S3 from Bladder Preservation with Durvalumab plus Tremelimumab and Concurrent Radiotherapy in Patients with Localized Muscle-Invasive Bladder Cancer (IMMUNOPRESERVE): A Phase II Spanish Oncology GenitoUrinary Group Trial
Authors: Garcia-del-Muro Xavier , P. Valderrama Begoña , Medina-Colmenero Ana , Etxaniz Olatz , Gironés Sarrió Regina , Juan-Fita María José , Costa-García Marcel , Moreno Rafael , Miras Rodríguez Isabel , Ortiz Irene , Cuéllar Andrés , Ferrer Ferran , Vigués Francesc , de Haro Piedra Roberto , Candal Gomez Arturo , Villà Salvador , Pontones José Luis , Murria Yasmina , Lendínez-Cano Guillermo , Alemany Ramon
Published: February 2025

Supplementary Table 3. Representativeness of Study Participants.
Supplementary Table 1 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Table 1
Supplementary Figure 2 from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

Supplementary Figure 2
Supplementary Table S6 from Smoking-Associated Carcinogen–Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Authors: Aggarwal Ritesh K. , Sidoli Simone , Wang Jingli , Sahu Srabani , Sanawar Rahul , Gupta Varun , Aluri Srinivas , Sukrithan Vineeth , Vegivinti Charan T.R. , Zavras Phaedon D. , Verma Divij , Gordon-Mitchell Shanisha , Agarwal Beamon , Verma Tanya , Starczynowski Daniel T. , Steidl Ulrich G. , Shastri Aditi , Halmos Balazs , LaFave Lindsay M. , Cheng Haiying , Verma Amit , Zou Yiyu
Published: February 2025

Supplementary Table S6. Manuscript Figure 6 data - The Excel file has data points for easy access to infer numerical values for data presented in the manuscript. Also see Data Availability Statement.
Supplementary Table S3 from Next-Generation Sequencing–Based MSI Scoring Predicts Benefit in Mismatch Repair–Deficient Tumors Treated with Nivolumab: Follow-up on NCI-MATCH Arm Z1D
Authors: Schoenfeld Jonathan D. , Azad Nilofer S. , Gross Jacob , Chen Li , Overman Michael J. , Kao Katrina , Jackson Latifa , Brunnquell Donna , Bu Xiangning , Coppola Christina , Guan Ping , Lee Jennifer , Sims David , Fuchs Rebecca , Weirather Jason L. , Pfaff Kathleen L. , Gunasti Lauren , Ranasinghe Srin , Hamilton Stanley R. , Wang Victoria , O’Dwyer Peter J. , Wu Catherine J. , Rodig Scott J. , Patton David R. , Harris Lyndsay
Published: February 2025

Antigen retrieval, primary antibody incubation, and OpalTM Fluorophore incubation for multiplex immunofluorescence
Supplementary Figure S6 from Smoking-Associated Carcinogen–Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Authors: Aggarwal Ritesh K. , Sidoli Simone , Wang Jingli , Sahu Srabani , Sanawar Rahul , Gupta Varun , Aluri Srinivas , Sukrithan Vineeth , Vegivinti Charan T.R. , Zavras Phaedon D. , Verma Divij , Gordon-Mitchell Shanisha , Agarwal Beamon , Verma Tanya , Starczynowski Daniel T. , Steidl Ulrich G. , Shastri Aditi , Halmos Balazs , LaFave Lindsay M. , Cheng Haiying , Verma Amit , Zou Yiyu
Published: February 2025

Supplementary Figure S6. Downregulated phosphorylations after IRAK4 inhibitor treatment.
Supplementary Figure S3 from Smoking-Associated Carcinogen–Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Authors: Aggarwal Ritesh K. , Sidoli Simone , Wang Jingli , Sahu Srabani , Sanawar Rahul , Gupta Varun , Aluri Srinivas , Sukrithan Vineeth , Vegivinti Charan T.R. , Zavras Phaedon D. , Verma Divij , Gordon-Mitchell Shanisha , Agarwal Beamon , Verma Tanya , Starczynowski Daniel T. , Steidl Ulrich G. , Shastri Aditi , Halmos Balazs , LaFave Lindsay M. , Cheng Haiying , Verma Amit , Zou Yiyu
Published: February 2025

Supplementary Figure S3. Exposure to carcinogens leads to carcinogenesis in murine lungs: Representative histological examples of mouse lung carcinogenesis observed during the study to assess the effect of smoking carcinogens.
Supplemental Figure 1 from Phase I/II Trial of Exportin 1 Inhibitor Selinexor plus Docetaxel in Previously Treated, Advanced KRAS-Mutant Non–Small Cell Lung Cancer
Authors: von Itzstein Mitchell S. , Burns Timothy F. , Dowell Jonathan E. , Horn Leora , Camidge D. Ross , York Sally J. , Eaton Keith D. , Kyle Kelly , Fattah Farjana , Liu Jialiang , Mu-Mosley Hong , Gupta Arjun , Nadeem Urooba , Gao Ang , Zhang Song , Gerber David E.
Published: February 2025

Supplemental Figure 1. Next generation sequencing results (n=16 cases).
Table S1 from Human Pancreatic Cancer Single-Cell Atlas Reveals Association of CXCL10+ Fibroblasts and Basal Subtype Tumor Cells
Authors: Loveless Ian M. , Kemp Samantha B. , Hartway Kailee M. , Mitchell Jacob T. , Wu Yuesong , Zwernik Samuel D. , Salas-Escabillas Daniel James , Brender Sydney , George Madison , Makinwa Yetunde , Stockdale Thais , Gartrelle Kendyll , Reddy Rohit G. , Long Daniel W. , Wombwell Allison , Clark Julie M. , Levin Albert M. , Kwon David , Huang Ling , Francescone Ralph , Vendramini-Costa Débora B. , Stanger Ben Z. , Alessio Adam , Waters Andrew M. , Cui Yuehua , Fertig Elana J. , Kagohara Luciane T. , Theisen Brian , Crawford Howard C. , Steele Nina G.
Published: February 2025

Supplemental Table S1
Tumor Cell Plasticity and Stromal Microenvironment Distinguish Papillary and Follicular Growth Patterns in a Mouse Model of BRAFV600E-induced Thyroid Cancer
Authors: Schoultz Elin , Moccia Carmen , Liang Shawn , Johansson Ellen , Nilsson Mikael
Published: February 2025

Differentiated thyroid cancer primarily classified by tumor histology comprises follicular thyroid carcinoma (FTC) and papillary thyroid carcinoma (PTC), which represent distinct malignancies regarding pattern of tumor spreading, responsiveness to radioiodine treatment and clinical outcome. As FTC and PTC also differ genetically i.e. RAS mutations predominate in FTC whereas mutant BRAF is much more frequent in PTC, it is assumed although yet unproven that the archetypical tumor growth pattern – follicular versus papillary – depends on mutation identity and potentially the graded signaling output of the MAPK pathway that differs in response to constitutive activation by RAS or BRAF. Here we show by clonal tracing in mice carrying a Braf mutant allele with targeted expression of BRAFV600E exclusively in the thyroid gland that sporadically developed tumors either adopt a follicular or a papillary phenotype depending on follicle origin. Moreover, a single tumor clone may transit from papillary to follicular growth associated with asymmetric distribution of stromal tissue in the immediate vicinity of the tumor. Key to these observations is monitoring progeny of cells undergoing spontaneous recombination of both BrafCA and the reporter gene due to Cre leakage which, in contrast to after induced oncogene activation comprising all target cells, implies that tumors develop stochastically and asynchronously originating from a limited number of BRAF mutant cells and taking place within a preserved thyroid tissue microenvironment. The results suggests that the natural heterogeneity of follicles and tumor cell plasticity modify BRAFV600E-induced neoplastic growth leading to divergent tumor histogenesis.
Video forgery: An extensive analysis of inter-and intra-frame manipulation alongside state-of-the-art comparisons
Authors: Shaikh Sumaiya , Kannaiah Sathish Kumar
Published: February 2025

The widespread accessibility of inexpensive mobile phones, digital cameras, camcorders, and security closed-circuit television (CCTV) cameras has resulted in the integration of filmmaking into our everyday existence. YouTube, Facebook, Instagram, and Snapchat are a few of the video-sharing and editing applications that facilitate the process of uploading and editing videos. Additional instances include Adobe Photoshop, Windows Movie Maker, and Video Editor. Although editing has its advantages, there is a potential risk of counterfeiting. This occurs when films are edited with the intention of misleading viewers or manipulating their perspectives, which can be particularly troublesome in judicial procedures where recordings are submitted as evidence. The issue has been exacerbated by the emergence of deep learning methods, such as deepfake videos that effectively manipulate facial characteristics. Consequently, individuals have become less reliant on visual evidence. These issues emphasise the pressing necessity for the creation of dependable methods to determine the authenticity of films and identify cases of fraud. Contemporary methods can depend on assessing modified frames or utilising distortions generated during video codec compression or double compression. Since 2016, multiple studies have been undertaken to investigate techniques, strategies, and applications to tackle this problem. The objective of this survey study is to provide a comprehensive analysis of these algorithms, highlighting their advantages and disadvantages in detecting different forms of video forgeries.
Emotional education in post-pandemic times: emerging needs and educational response
Authors: González-Herrera Ana Isabel , Yanes-Rodríguez Laura , Reyes-González Natalia , Alonso-Rodríguez Isabel , Pérez-Jorge David
Published: February 2025

COVID-19 has provoked a rapid adaptation in the post-pandemic period, posing a great challenge for all areas, particularly education. This paper presents an action-research study in a Spanish educational institution, aiming to determine the emotional impact that COVID-19 has left on primary school students, with special attention to students with specific educational needs (SEN). In addition, the aim was to articulate a proposal for improving emotional education addressed at school. As a result of this study, the socio-affective needs of the pupils and the benefits of psychomotricity and artistic education for strengthening emotional development have been discovered. As a result, an innovative project has also been proposed for educational guidance and tutoring at CPEIPS La Salle La Laguna, based on the programming of cross-cutting units in various subjects to optimize the socio-emotional and psychomotor development of the students.
Development and instrument validation of Indonesian achievement motivation scale using the Rasch model
Authors: Wiyono Bambang Dibyo , Hidayah Nur , Ramli Muhammad , Atmoko Adi , Shafie Amin Al-Haadi
Published: February 2025

This research involves the development of items on an achievement motivation scale that is used in improving the achievement motivation of senior high school students. No research on instrument development has been carried out on measuring the level of achievement motivation of senior high school students in Indonesia. Participants tested the development of 38 items and consisted of 1,909 respondents as students from senior high schools in the City of Surabaya. The utilized analysis technique was the Rasch model. Results of applying the Rasch analysis indicated that achievement motivation scale was good, proper, and appropriate in items to the model. The accomplishment motivation scale is a valid and dependable instrument for precisely determining pupils’ levels of accomplishment motivation. In light of the achievement motivation scale results, this study explores the consequences and suggests directions for future research on the use of guidance and counseling.
Computer science and educational games to enhancing students’ Islamic content learning
Authors: Tlili Ahmed , Chikhi Salim
Published: February 2025

Learning in all humanities content branch such as Islamic sciences is declared to be boring, tiring and very dry plain content because the educational level of learners becomes low and worrying. This statement is justified by the result of our statistical study which reveals that learning of Islamic content is not attractive and needs to be revolutionized in order to make it more attractive and interesting for the new generation called digital generation. In this paper, we have used the gamification concept with learning analytics (LA) approach to design an educational game to improve Islamic content learning. However, and due to the lake of works and the knowledge about teaching Islamic contents using education games look insufficient and at their begins. The obtained results, in this study, with proposed approach, shows that the students had remarkably higher motivation and performance to learn than before. The main objective of this investigation is, firstly, allows managers and teachers easily incorporate LA approaches to help student improves their learning; and secondly, future work benefits from these results to define an appropriate dashboard for the Islamic content learning and teaching.
Exploring new feedback practices paradigm in higher education: students’ perspectives
Authors: Genisa Marlina Ummas , Rizal Haryanti Putri , Hasri Hasri , Agussalim Andi
Published: February 2025

Feedback has recently shifted from being received to being an interaction process, raising considerable interest among educators. This study aims to examine whether current feedback practices in higher education have led to active student interaction processes, and how individual and contextual factors are considered in practice based on gender and university perspectives. An online questionnaire was used to collect data from 418 students from three Indonesian universities, Universitas Negeri Makassar (UNM), Universitas Muhammadiyah Palembang (UMP), and Universitas Sulawesi Barat (USB). The data was analyzed descriptively-quantitatively. Results indicate that current feedback practices do not adequately direct students to actively participate in the processing feedback. The feedback received is dominated by general feedback (UNM and USB), while detailed and discussed feedback is generally received by UMP students. Additionally, the expected and effective feedback obtained the same pattern that individuals and groups must interact which is in line with the new paradigm. The results also showed the ideal time for providing feedback is 5-10 days for various types of assignments and 15-20 days for theses. These results provide educators with information on strategies and approaches in feedback practices that are relevant and effective in enhancing student learning based on the new paradigm.
Recommended improvements for online learning based on Omani students’ experiences and perspectives
Authors: AL-Busaidi Zakiya Nasser , Rajesh Preethy
Published: February 2025

The outbreak of COVID-19 prompted a worldwide transition to online education in academic institutions, which had a profound effect on both instructors and learners. This study aims to investigate the perspectives and experiences of students who have undergone emergency remote learning at the University of Technology and Applied Sciences (UTAS) in the Nizwa branch. The study explored students’ experiences in four areas: i) the impact of online learning on academic performance, learning skills, communication, health, and motivation; ii) students’ preferences; iii) the challenges they faced; and iv) the suggestions they have for enhancing the online learning environment. An online survey was conducted with 447 students, and the data collected were analyzed both quantitatively and qualitatively. This study shows that online learning has impacted students’ academic performance, communication, health, and motivation. The findings revealed that students preferred live online lectures and exams but were dissatisfied with the online learning system overall. Content analysis revealed that the most significant challenges faced by students were technical issues, study-related concerns, and learning difficulties. These findings highlight the necessity of enhancing the infrastructure, fostering communication, and implementing effective teaching methods to create a more engaging and productive online learning environment.
Adaptation and validation of academic resilience scale in Bengali
Authors: Ahmed Riya , Panda Bijoy Krishna , Sinha Muktipada
Published: February 2025

The purpose of the current study was to adapt and validate the Academic Resilience Scale (ARS-30) in the context of West Bengal and other Bengali-speaking regions. The research included a total of 628 participants. The data analysis occurred in three stages. Initially, confirmatory factor analysis was employed to assess the factorial validity of the Bengali version of ARS-30 scale, revealing a poor fit for the original three-factor model. Subsequently, further exploratory factor analysis (EFA) suggested a more suitable two-factor structure. In the third stage, this newly derived two-factor structure was validated through confirmatory factor analysis (CFA) with an independent sample. The adapted scale, renamed ARS-19, measures two factors related to academic resilience: negative affect and emotional response (6 items) and positive adaptation (13 items). Results from validity and reliability analyses indicated that the ARS-19 is a valid and reliable tool for assessing academic resilience in the aforementioned context. This study contributes to the literature by proposing a valid and reliable academic resilience measurement for West Bengal as well as other Bengali-speaking regions, facilitating practitioners in assessing academic resilience among higher education students.
Multiple intelligence based tasks for enhancing reading motivation of university students in Ethiopia
Authors: Gebremeskel Teshale Alemu , Bachore Mebratu Mulatu , Bushisso Elias Woemego
Published: February 2025

The purpose of the study was to investigate the effectiveness of multiple intelligence-based tasks in enhancing students’ motivation towards reading. It employed a quasi-experimental design. A total of 60 communicative English class university students, who were selected purposefully participated as treatment and comparison groups. The research process was carried out with reading tasks that were designed based on a model for teaching using multiple intelligence-driven tasks for the treatment group while the comparison group followed the conventional approach for 12 weeks. English-reading motivation questionnaires and focused group discussions were used to gather data. Data normality check was carried out using Shapiro-Wilk tests, and a p value of 0.05 was used to determine the level of significance. T-tests were used to compare the scores between the two groups. It was found that multiple intelligence-based reading tasks (MIBRT) brought a significant difference in the students’ motivation, with the effect size value ranging from low (for importance), moderate (for efficacy and for extrinsic), and strong (for intrinsic). It was suggested that university teachers should use multiple intelligence-driven reading tasks as an alternative scaffolding tools to raise the motivational levels of struggling readers in the context of the study.
Training of social educators on prevention of the propensity of adolescents to victim behavior
Authors: Murzagulova Meiramkul , Atemova Kalipa , Kudaibergenova Aliya , Bayarystanov Elmira , Sembayeva Ardak , Massimbayeva Aiym , Zhanybekova Ltifat
Published: February 2025

This study focused on assessing the impact of a specialized training program in dealing with victim behavior among teenagers. A total of 200 social educators from Kazakhstan participated in the study, evenly divided into an experimental group, which underwent training, and a control group, which did not receive training. A 100-point test was used in the study to evaluate pre-and post-training assessments. The average score on the pre-tests in both groups was 43. After the training, a significant increase in scores was observed in the experimental group, averaging 75.74, indicating the effectiveness of the training. The control group showed a slight increase with an average post-test score of 48.73. Statistical analysis underscored the impact of the training. Paired sample t-test for the experimental group revealed a significant mean difference with a significant value (p<0.001). The change in the control group was also significant but small (p<0.001). Independent samples t-test between the group results after testing indicated that the success of the experimental group was significantly higher (p<0.001). These results demonstrate the value of targeted training to enhance the capabilities of social educators in managing the behavior of victimized adolescents, emphasizing the need for such specialized programs in educational institutions.
Attitude toward flexible learning of college students in Albay, Philippines
Authors: Bercasio Rebecca Rosario Oroña , Dugan Marinel Agustin
Published: February 2025

Instructional delivery was significantly disrupted by the COVID-19 pandemic worldwide, which led to a flexible modality of teaching-learning. This flexible learning modality challenged the readiness of schools and affected the students. This study determined college students’ attitudes toward flexible learning during the COVID-19 pandemic in Albay Province, Philippines, using the explanatory sequential design of the mixed-methods approach. Data were gathered from 365 college students using an online survey, virtual focus group discussions, and informal interviews with 20 students. Salient findings showed that the students generally had favorable attitudes toward flexible learning, with favorable attitudes toward four dimensions: attitudes toward the teacher, learning resources, teaching methods and learning tasks, and technology tools, and neutral attitudes in two dimensions, namely, attitude toward assessment and support services. The students revealed favorable, neutral, unfavorable, and a combination of attitudes toward flexible learning as discerned from their experiences. The students’ experiences indicate that inspiring and competent teachers are crucial figures in sustaining a favorable attitude of students toward flexible learning. This study provides insights into the gaps in implementing flexible learning through the students’ perspectives, especially regarding the schools’ readiness for and improvement of flexible learning in the post-COVID-19 pandemic.
The influence of virtual laboratories on students’ interest in STEM fields: a longitudinal study in secondary education
Authors: Karimova Batesh , Zhumabekova Bibigul , Hamzina Sholpan
Published: February 2025

The objective of this article is to investigate the impact of virtual laboratories (biology, chemistry, physics, and mathematics) on students’ interest in science, technology, engineering, and mathematics (STEM) fields over six months of study. The study involved 317 participants from Alkey Margulan Pavlodar Pedagogical University (Pavlodar Region, Kazakhstan), who were divided into experimental and control groups. An experimental approach was employed, wherein participants underwent training using virtual laboratories for six months. Statistical methods, specifically t-tests for paired and independent samples, were employed to analyze the results. The experiment revealed a statistically significant positive influence of virtual laboratories on students’ interest in STEM fields. Participants in the experimental group exhibited an increased interest in biology, chemistry, physics, and mathematics compared to the control group. The research findings hold important practical implications for enhancing STEM education. The implementation of virtual laboratories may contribute to an increase in students’ interest in studying STEM disciplines, which is crucial for shaping the future generation of specialists in these fields. Future considerations should involve exploring various types of virtual laboratories, taking into account sociocultural context, and addressing individual differences among students. Additionally, it is essential to investigate the longer-term effects of using digital technologies in STEM education.
Effectiveness of an author’s program for psychopedagogical support in the development of metacognitive abilities
Authors: Popandopulo Anar , Kudysheva Ainash , Kudarova Nazgul , Matayev Berik , Antikeyeva Samal
Published: February 2025

In the context of the updated educational system emphasizing autonomy and critical thinking among students, it is necessary to develop effective approaches to support and enhance students’ metacognitive abilities. This research aims to evaluate the effectiveness of a proprietary psychological and pedagogical support program designed to develop metacognitive abilities in schoolchildren. Methods included conducting a quasi-experimental study with control and experimental groups, utilizing the metacognitive awareness assessment questionnaire (MAAQ) to assess outcomes. The study involved 184 students (grades 7-9; M=14.40; SD=0.81) from a school in Kazakhstan, where the experimental group underwent the intervention program. Statistical analysis revealed significant improvements in metacognitive abilities among students in the experimental group compared to the control group, including enhancements in self-awareness, self-regulation, critical thinking, decision-making, and problem-solving. These findings affirm the feasibility of integrating metacognitive approaches into educational programs and suggest further avenues for research in pedagogical support and student development.
High school students’ 21st-century learning skills in organic chemistry group learning
Authors: Sa-ngiemjit Maneerat , Vázquez-Alonso Ángel , Manassero-Mas María-Antonia
Published: February 2025

Children with 21st-century learning abilities thrive in today’s globalized world, underscoring the importance of early skill development by both schools and parents. This study aims to evaluate high school students’ grasp of organic chemistry in relation to critical thinking, creativity, communication, and collaboration skills. Conducted with 15 groups of
 grade 12 students in science-mathematics, the research employed a mixed-methods approach, combining written surveys and observations. Statistical tools such as averages, standard deviations, and correlation coefficients were utilized for data analysis, followed by specific statistical tests to ensure validity and significance. Correlation analysis was used to examine the relationships between each 21st-century learning skill. Findings indicate that in organic chemistry, students hone critical thinking through data evaluation, and problem-solving, while fostering creativity in molecule synthesis and solution-finding. Effective communication fosters collaboration and teamwork, essential for achieving common goals. Average scores from writing surveys for critical thinking, creativity, and communication were 1.62, 1.65, and 1.68, respectively, with collaboration evaluated through observation scoring 2.03. Notably, a significant positive correlation was found between each skill, indicating that enhancing one skill often leads to improvements in the others. This highlights the importance of a holistic approach to developing 21st-century educational abilities.
The specifics of developing the social intelligence of Oralman students with artificial intelligence
Authors: Dyussenova Alua , Mandykayeva Almagul , Mambetalina Aliya , Menlibekova Gulbakhyt , Aitysheva Aigul , Nurkatov Yerbol
Published: February 2025

This study examines the impact of an educational program based on artificial intelligence (AI) on improving social intelligence among Oralman students (a group of repatriates from among ethnic Kazakhs who faced unique integration problems in Kazakhstan). The main objective was to assess whether targeted interventions can effectively improve social skills that are crucial for successful social integration. The study involved 300 students aged 20 to 22 years, divided into experimental and control groups. Students participated in a six-month AI program designed to develop social intelligence using interactive tools and modeling. Pre-test and post-test assessments used the Tromso social intelligence scale (TSIS), focusing on areas such as social information processing, social skills, and social awareness. Following the intervention, the outcomes revealed that the experimental group had made notable progress in every area that was examined. Specifically, in this group, the overall score increased significantly from 59.37 to 82.33, and the average post-test scores climbed to 25.87 for social information processing, 27.33 for social skills, and 29.13 for social awareness. On the contrary, minimal changes observed in the scores of the control group emphasize the effectiveness of the AI-based program. The analysis of secondary data further confirmed the results: t-tests showed statistically significant differences in the post-test scores between the groups. The progress of the experimental group highlights the potential of AI-based educational tools in the development of basic social competencies, offering promising opportunities to support the integration of Oralman students into Kazakh society.
Telecommunication project methods as an effective tool in modern education
Authors: Lebedeva Marina , Beketov Vladimir , Taranova Marina
Published: February 2025

This article is devoted to the study of the problem of insufficient involvement of philology students in the educational process, which negatively affects their academic performance. To solve this problem, a telecommunication project was developed and implemented to improve learning efficiency and student engagement. The research was based on a pilot project with one group, and survey methods were also utilized to measure the level of student engagement in the learning process. Statistical analysis results indicate a noticeable improvement in students’ academic performance after the implementation of the innovative telecommunication course, with the average score increasing from 75.5 to 80.1, supported by a statistically significant level. Survey data on student engagement demonstrate a high level of positive attitude towards the use of technology in the educational process. The overall trend indicates a positive attitude towards new technologies in education. The practical significance of this article lies in highlighting telecommunication project methods as an effective tool in modern education. Applying the results of this research in educational practice can contribute to the development and implementation of new educational programs based on telecommunication projects.
Systematic Literature Review on Developing an Integrated STEM Leadership Model for Middle Leaders in School
Authors: Rahman Saifulbahri Abdul , Busari Abdul Halim , Mazlan Mohammad Nur Azhar , Suhaili Adawati
Published: February 2025

This systematic literature review investigates the development of anintegrated science, technology, engineering, and mathematics (STEM)leadership model tailored for middle leaders in Malaysian schools. Theintroduction highlights the global emphasis on STEM education to fosterinnovation and economic growth, while acknowledging Malaysia’scommitment to enhancing STEM capabilities within its educational system.The problem statement identifies a gap in effective STEM leadership amongmiddle leaders, which is critical for implementing STEM initiatives andimproving student outcomes. To achieve this, we conducted an extensivesearch of scholarly articles from reputable databases such as Scopus and Webof Science (WoS), focusing on studies published between 2021 and 2024. Theflow of study is based on PRISMA framework. The database found (n=34)final primary data was analyzed. The finding was divided into three themeswhich are i) STEM education policy and implementation; ii) leadership inSTEM educational; iii) professional development in STEM education. Theconclusion emphasizes the need for a specialized leadership model thatincorporates instructional leadership principles, fosters professionaldevelopment, and supports collaborative practices among middle leaders. Thisintegrated model aims to address the unique challenges faced by middleleaders in Malaysian schools, ultimately enhancing STEM education andcontributing to Malaysia’s educational and economic aspirations.
Position and orientation analysis of Jupiter robot arm for navigation stability
Authors: Shalash Omar , Sakr Adham , Salem Yasser , Abdelhadi Ahmed , Elsayed HossamEldin , El-Shaer Ahmed
Published: February 2025

Jupiter robot has made a great impact in the educational field with its support for autonomous navigation, visual perception, and many other features from its artificial intelligence platform's learning box. This study undertakes a kinematic model design of Jupiter's arm to aid the robot's motion stability. This process involved the determination of a homogeneous transformation matrix, followed by the determination of orientation, position, and Euler angles. Ultimately, the homogeneous transformation matrix was successfully derived, and the simplification of direct kinematic matrices was achieved. Consequently, the kinematic analysis for Jupiter's arm was established using the position Denavit–Hartenberg method, orientation, and Euler angles, proving to be valuable in the context of this research.
Position tracking of DC motor with PID controller utilizing particle swarm optimization algorithm with Lévy flight and Doppler effect
Authors: Mohamed Azmi Nur Iffah , Mat Yahya Nafrizuan
Published: February 2025

This paper presents the implementation of the particle swarm optimization with the Lévy flight Doppler effect (PSO-LFDE) algorithm for optimizing proportional-integral-derivative (PID) controller parameters in a direct current (DC) motor system. Traditional optimization algorithms like particle swarm optimization, whale optimization algorithm, grey wolf optimizer, and moth flame optimization often face challenges in balancing exploration and exploitation, leading to suboptimal performance. The proposed PSO-LFDE algorithm addresses these issues by incorporating Lévy flight for enhanced exploration and the Doppler effect for refined exploitation. The algorithm is validated using MATLAB/Simulink for position control in a DC motor system with step inputs of 10, 30, and 60 cm. Key performance metrics, including rise time, settling time, peak time, and steady-state error, were compared against other optimization methods. PSO-LFDE demonstrated superior performance, achieving a 41.63% improvement in rise time and a 70.20% reduction in peak time compared to other methods. These results highlight PSO-LFDE's effectiveness in optimizing PID controller parameters and improving the dynamic response of DC motor systems, offering a robust solution for real-world control applications.
Enhancing efficiency and reliability in high-power microwave amplifiers: a novel circuit driver approach
Authors: Jebelli Ali , Lotfi Nafiseh , Partovibakhsh Maral , Mahabadi Arezoo , Zare Mohammad Saeid
Published: February 2025

This paper introduces an innovative circuit driver engineered to significantly enhance the efficiency and longevity of high-power microwave amplifiers, addressing critical limitations of traditional drivers in handling high-power systems. The proposed design features advanced voltage sequencing, which is crucial for extending component life and ensuring safe operation within the safe operating area (SOA). By integrating a sophisticated circuit board with real-time feedback sensors, controlled by a microcontroller, the system ensures continuous monitoring and rapid response to potential operational hazards. The driver automatically engages a fail-safe mode when thresholds are breached, prioritizing efficiency optimization and minimizing energy waste. Rigorous testing has confirmed the circuit driver’s capability to meet and exceed the stringent demands of high-power microwave amplifier applications. This work offers a robust, reliable solution that not only overcomes existing challenges but also sets a new standard for the performance and safety of microwave amplification systems, making it a valuable contribution to the field of power electronics.
Pengaruh Kualitas Pelayanan Pendekatan Terra terhadap Kepuasan Pasien
Authors: Hamid H. M. , Mulyani S. R. , Wirawan C.
Published: February 2025

The purpose of this research is to carry out a more explicit analysis regarding facilities and physical evidence, empathy, responsiveness, reliability, service guarantee, and patient satisfaction. The objects of this research were patients at Sariningsih Hospital in Bandung with a sample of 99 respondents. The data analysis used is multiple linear regression analysis, correlation coefficient analysis, and coefficient of determination analysis. Based on the multiple regression analysis equation model, the results show that there is a positive and unidirectional functional relationship between the variabels, which is Y = -1.596 + 0.388X1 + 0.440X2 + 0.338X3 + 0.103X4 + 0.353X5. It means that every change in the independent variabel can affect the dependent variabel as well. This is in line with the results of the correlation coefficient which shows a very strong relationship (0.944) and the coefficient of determination (89.1%) shows a large influence. Thus, to increase patient satisfaction, we firstly must pay attention to the quality of service.
A simple model of the tropical cyclone boundary layer at landfall
Authors: Kepert Jeffrey D.
Published: February 2025

As a tropical cyclone approaches landfall, it progressively experiences asymmetric friction that directly modifies the boundary-layer flow, since the land surface is rougher than the sea. An idealised model of the boundary layer flow within a stationary cyclone, located exactly on the coast, is presented. This model is linearised and utilises simple representations of the turbulent fluxes. These simplifications enable analytical solutions, which represent the flow as the sum of three components: a symmetric component and two asymmetric components of azimuthal wave-number one, which rotate with height. The stronger asymmetric component rotates anticyclonically with height, and the weaker one cyclonically. The solution is thereby similar to that for a moving cyclone over sea, except that (i) the symmetric component has larger amplitude, because the azimuthal-mean surface roughness is greater, and (ii) the amplitudes and phases of the asymmetric components are different because of the different surface boundary condition. The linear solutions are compared to simulations using a nonlinear model with more sophisticated representations of the turbulent fluxes, and it is shown how to extract the two asymmetric components from the flow in this latter model. This study complements the analysis of the observed wind asymmetry in Tropical Cyclone Veronica in a companion paper.
Buckling analysis of perforated stiffened composite plates with interfacial debonding under hygrothermal and in-plane edge loadings
Authors: Kalgutkar Akshay Prakash , Banerjee Sauvik
Published: February 2025

Engineered composite structures often incorporate stiffeners to enhance the strength of perforated panels without significantly increasing their mass. However, interfacial debonding between the stiffener and skin can compromise structural integrity under external loads, potentially leading to failure. This study focuses on the buckling behaviour of stiffened perforated laminated plates with interfacial debonding, subjected to non-uniform edge loading and environmental conditions. A computationally efficient reduced-order finite element (FE) formulation has been devised using the 2D plate and 1D beam elements to minimise the computational cost. The plate and stiffener flange are modelled using a 9-noded heterosis element to address shear-locking, while a 3-noded isoparametric beam element represents the stiffener web and ribs. To account for stiffener torsional behaviour, a torsion correction factor is incorporated into the stiffener web and ribs formulation. Interfacial debonding is simulated by introducing a dummy node with an independent displacement field for the stiffener flange, connected by the fictitious spring between the plate and the penetrated flange nodes, to prevent nodal interpenetration. Displacement continuity is enforced in the bonded regions to maintain compatibility between the stiffener and plate displacement fields. The study employs a dynamic approach to evaluate buckling loads under two boundary conditions, considering operational and environmental effects. Additionally, hygrothermal-dependent material properties are considered to incorporate the effect of hygrothermal loading on the elastic behaviour of the material. A preliminary investigation identifies an optimal loading pattern and cutout geometry for enhanced buckling performance. In contrast to prior research, this work examines various stiffener configurations to evaluate the stability of perforated plates under non-uniform edge loading and determines the configuration that improves buckling capacity. The analysis indicates that the circular cutout panel incorporating the SP-3 stiffener configuration demonstrates a 42.86% improvement in buckling resistance compared to the SP-2 stiffener design. Furthermore, debonding significantly reduces the buckling capacity of the CCSS panel by 20.14%, especially at greater stiffener depths of d s /b s = 7 under hygrothermal conditions. Moreover, larger cutout sizes exacerbate stability reductions of the CCSS panel by 2.70% due to debonding under the reference hygrothermal state. In contrast, debonding under hygrothermal conditions results in a 38.44% reduction in the buckling strength of the smaller cutout SSCC panel, highlighting the impact of restraint conditions. Therefore, this study serves as a foundation for optimising designs to ensure stability, durability, and cost-effectiveness in demanding operational scenarios.