bluuebunny/crossref_metadata_2025 huggingface dataset:
Ołtarze Boże – naszym przytułkiem
Authors: Hello Ernest
Published: April 2018

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Instrukcja o należytym odprawianiu wznowionego porządku Wielkiego Tygodnia
Authors: Kongregacja Obrzędów Święta
Published: April 2018

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Potrójne kuszenie Chrystusa na tle marzeń mesjańskich
Authors: Smereka Władysław
Published: April 2018

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Novi et aeterni Testamenti
Authors: Jankowski Augustyn
Published: April 2018

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Przechowywanie Najśw. Sakramentu
Authors: Szwagrzyk Tadeusz
Published: April 2018

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Reguła Zrzeszenia z Qumran
Authors: Łach Jan
Published: April 2018

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Eucharystia a wychowanie i samowychowanie
Authors: Sczaniecki Paweł
Published: April 2018

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Aktualne zagadnienia eklezjologii
Authors: Przybylski Bernard
Published: April 2018

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Manuskrypty z Qumran a chrześcijaństwo
Authors: Grzybek Stanisław
Published: April 2018

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Ocena władzy królewskiej w Księdze Ozeasza
Authors: Sitarz Eugeniusz
Published: April 2018

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Pawłowy charakter nauki dogmatycznej i moralnej listów do Tessaloniczan
Authors: Stępień Jan
Published: April 2018

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J. E. ks. biskup dr Julian Groblicki
Authors: Grzybek Stanisław
Published: April 2018

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Dekret Świętej Kongregacji Obrzędów o odmawianiu modlitw po mszy czytanej
Authors: Kongregacja Obrzędów Święta
Published: April 2018

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Miłość błogosławiąca (materiał do pogadanki ewangelicznej)
Authors: Żurowska Felicja
Published: April 2018

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Drogi Jezusowe
Authors: Grabianka Stanisław L.
Published: April 2018

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Oczekiwanie paruzji w Listach św. Pawła
Authors: Stępień Jan
Published: April 2018

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Złote jubileusze kapłańskie
Authors: Grzybek Stanisław
Published: April 2018

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Wyjaśnienia Świętej Kongregacji Obrzędów
Authors: Kongregacja Obrzędów Święta
Published: April 2018

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O formach czynnego udziału wiernych we mszy świętej
Authors: Buxakowski Jerzy
Published: April 2018

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Kościół i artysta
Authors: Zieliński Chwalisław
Published: April 2018

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Wychowanie alumna i kapłana przez liturgię
Authors: Małaczyński Franciszek
Published: April 2018

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Instrukcja Komisji Biblijnej w sprawie historyczności ewangelii
Authors: Klawek Aleksy
Published: April 2018

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Dyskusje nad istotą natchnienia biblijnego
Authors: Homerski Józef
Published: April 2018

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Kto jest moim bliźnim
Authors: Grzybek Stanisław
Published: April 2018

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Nieszpory polskie w nowym przekładzie
Authors: Klawek Aleksy
Published: April 2018

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Geneza i założenia reformy liturgicznej
Authors: Schenk Wacław
Published: April 2018

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Terminologia soteriologiczna w Starym Testamencie (Jahwe-Zbawca)
Authors: Kubik Antoni
Published: April 2018

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Psalm Miserere
Authors: Klawek Aleksy
Published: April 2018

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Teologia a magisterium Ecclesie (przemówienie Ojca św. Pawła VI z dn. 1 X 1966 r.)
Authors: VI Paweł
Published: April 2018

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Konstytucja apostolska papieża Pawła VI „Indulgentiarum Doctrina” z dnia 1 I 1967
Authors: VI Paweł
Published: April 2018

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Liturgia a katecheza
Authors: Chromik Tadeusz , Kubik Władysław
Published: April 2018

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Śpiewy ordinarium missae w świetle odnowy liturgicznej
Authors: Pawlak Ireneusz
Published: April 2018

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Międzynarodowy tydzień muzyki kościelnej w Pampelunie
Authors: Burzawa Stanisław
Published: April 2018

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VI Międzynarodowy Kongres Studium Starego Testamentu
Authors: Grzybek Stanisław
Published: April 2018

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Śp. ks. Walenty Prokulski SJ (1888–1968)
Authors: Grzybek Stanisław
Published: April 2018

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Kontemplacja i Eucharystia
Authors: Wicher Władysław
Published: April 2018

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Najstarszy kult maryjny w Nazaret
Authors: Chmiel Jerzy
Published: April 2018

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Z historii liturgii chrztu
Authors: Schenk Wacław
Published: April 2018

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Dyrektorium duszpasterskie episkopatu Francji o chrzcie dzieci z 1965 r.
Authors: Danielski Wojciech
Published: April 2018

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Ks. Walenty Prokulski S. J., wybitny egzegeta N. Testamentu (1888–1968)
Authors: Drzymała Kazimierz
Published: April 2018

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Muzyka „beatowa” w Kościele
Authors: Rak Romuald
Published: April 2018

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Nowa redakcja „Collectanea Theologica”
Authors: Grzybek Stanisław
Published: April 2018

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„Christus annus est!”
Authors: Pisarzak Marian
Published: April 2018

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Biblia Tysiąclecia – jej wartość i znaczenie (konfrontacja z oceną ks. E. Dąbrowskiego)
Authors: Frankowski Janusz
Published: April 2018

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Liturgiczna formacja kapłana
Authors: Świerzawski Wacław
Published: April 2018

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Dekret
Authors: Kongregacja Kultu Bożego Święta
Published: April 2018

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Obrzędy bierzmowania
Authors: Kongregacja Kultu Bożego Święta
Published: April 2018

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Międzynarodowy Kongres Biblijny Starego Testamentu w Edynburgu
Authors: Wodecki Bernard
Published: April 2018

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Rzeczywistość historyczna w Rdz 14
Authors: Peter Michał
Published: April 2018

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Materiały pomocnicze do wykładów z biblistyki, pod red. ks. Stanisława Łacha i ks. Mariana Filipiaka, Lublin 1975
Authors: Szlaga Jan
Published: April 2018

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XII seminarium naukowe wykładowców liturgiki w Polsce, Kraków, 4–5 września 1974 r.
Authors: Danielski Wojciech
Published: April 2018

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Stan reform liturgicznych w Niemczech zach.
Authors: Fischer Baltazar
Published: April 2018

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Recepcia konštitúcie Dei Verbum a uplatnenie jej posolstva na Slovensku
Authors: Vaľková Miriam
Published: April 2018

Konstytucja dogmatyczna Dei Verbum spotkała się na Słowacji z pełnym i wszechstronnym przyjęciem. Od 1993 roku pracuje tu krajowa filia Katolickiej Federacji Biblijnej. W roku 2002 został przygotowany komentarz do tej konstytucji. Miały także miejsce liczne inicjatywy, jak seminaria oraz konferencje, w czasie których przybliżano społeczeństwu dokumenty soborowe oraz ich założenia teologiczne i duszpasterskie. Katolickie Dzieło Biblijne (Katolícke biblické dielo) realizuje na Słowacji konkretne projekty. W posiedzeniach członków Rady systematycznie bierze udział biskup, którego obecność jest potwierdzeniem ścisłej współpracy Dzieła Biblijnego z episkopatem. Konferencja Episkopatu Słowacji przygotowała list pasterski na 40-lecie ogłoszenia konstytucji Dei Verbum, w którym propaguje i zachęca do medytacyjnego czytania Pisma Świętego metodą lectio divina.
53. Kongres SNTS (Kopenhaga 1998)
Authors: Pisarek Stanisław
Published: April 2018

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Zamysły serca, czyli skłonność dobra i zła w nauczaniu biblijnym
Authors: Świerczek Edmund
Published: April 2018

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Teksty euchologicznie jako źródło teologiczne (euchologia liturgiczna)
Authors: Durak Adam
Published: April 2018

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Aspekty soteriologiczne Przymierza Synajskiego
Authors: Wodecki Bernard
Published: April 2018

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Świątynia Jahwe — sensacyjne wykopaliska archeologiczne na wzgórzu Arad
Authors: Mendecki Norbert
Published: April 2018

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Sprawiedliwość społeczna a odpowiedzialność indywidualna (Ez 18)
Authors: Witaszek Gabriel
Published: April 2018

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Zbawcza pedagogia nawrócenia w celebracji nabożeństw pokutnych
Authors: Durak Adam
Published: April 2018

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Trzysta lat istnienia i działalności ss. Wizytek w Krakowie (1681–1981)
Authors: Jarzyna Stanisław
Published: April 2018

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Kapłaństwo wspólne i kapłaństwo służebne w świetle ksiąg liturgicznych
Authors: Krakowiak Czesław
Published: April 2018

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Sesja Polskiego Towarzystwa Teologicznego w Krakowie poświęcona śp. ks. prof. Wacławowi Schenkowi
Authors: Koperek Stefan
Published: April 2018

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Dziecko przed urodzeniem w starożytnym świecie pogańskim
Authors: Bielas Lucjan
Published: April 2018

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Chorał Opolski, t. I. 1985; t. II: 1987: t III: 1989, Opole
Authors: Langkammer Hugolin
Published: April 2018

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Meaning Production in the Civil Religious Mozambique
Authors: Ngale Samuel Joina
Published: April 2018

The Tsonga tribal and Mozambican national identities are civil religious constructs. They resulted from sacrificial ritual performances, the expropriation of traditions and symbols, and the creation of sacred spaces. Formed as a linguistic, cultural, religious and tribal unity, the Tsonga provided a historical genealogy and structural template for the emergence of Moçambicanidade as a civil religion. Drawing upon postcolonial theory and discourse analysis, the essay uses the analytical category “civil religion” as a focusing lens in order to explore the dynamics of national solidarity in selected main archival sources: First, the construction of the Tsonga narratives of the tiMhamba, the Sacred Woods and the expropriation of local traditions recorded in Henri-Alexandre Junod’s, the Life of a South African Tribe; second, the pedigree of a heightened value for union, Protestant work-ethics and education, bequeathed to Eduardo Mondlane and evident in his The Struggle for Mozambique. Since the focus of the essay is on the productions of civil religion rather than their reception, evidence is drawn from textual analysis rather than from fieldwork methods. As a consequence of the analysis, the study argues that both Tsonga and Moçambicanidade are subaltern identities to modernity, perhaps destined to fail, but existing within the frame of modernity as its alter ego.
PREVALENCE AND DETERMINANTS OF ECHOCARDIOGRAPHIC LEFT VENTRICULAR HYPERTROPHY AMONG HYPERTENSIVE PATIENTS IN A TERTIARY CARE HOSPITAL
Authors: Aparajita Behera Anugya , Panda Priyambada , Mohapatra Dipti , Kumar Behera Suresh , Mohanty Arati
Published: April 2018

Objectives: This cross-sectional study was conducted during the year 2014–15 to determine the prevalence, pattern, and factors associated with left ventricular hypertrophy (LVH) among hypertensive patients attending a tertiary care hospital.Methods: A total of 400 eligible adult patients having essential hypertension were included in this study. After obtaining informed consent, all participants were examined with echocardiography and relevant information was collected using a well-structured questionnaire.Results: The mean age of study population was 52.3 ± 12.8 in years. Mean systolic (SBP) and diastolic blood pressure (DBP) was 149.8 ± 11.2 and 94.7 ± 4.9 mmHg, respectively. Among the study participants, 266 (66.5%) had LVH and concentric hypertrophy was the predominant (64.3%) LV geometric pattern. Multivariate logistic regression revealed that obesity, SBP, and DBP had significant positive association with LVH (p<0.05).Conclusion: Liberal use of echocardiography in hypertensive patients could be useful in early diagnosis of LVH and guiding treatment decision. There should be emphasis on controlling SBP, DBP, and body mass index of hypertensive patients so that further cardiovascular complications can be prevented.
EVALUATION OF BENZYLIDENE-ACETONE ANALOGUES OF CURCUMIN AS ANTITUBERCULOSIS
Authors: Safitri Cikra Ikhda Nur Hamidah , Ritmaleni Ritmaleni , Rintiswati Ning , Sardjiman Sardjiman , Kaneko Takushi
Published: April 2018

Objective: The objective of this research is to evaluate the effect of benzylideneacetone analog of curcumin against Mycobacterium tuberculosis (MTB) H37Rv.Method: The activity of benzylideneacetone analog of curcumin is evaluated using mycobacteria growth indicator tube (MGIT) method and microplate alamar blue assay (MABA) method. The compound of minimum inhibitory concentration (MIC) is defined as the minimum concentration of drugs which really inhibit the growth of MTB.Result: The MIC compound of 1,5-bis(3,4-dichlorophenyl)-1,4-pentadiene-3-one (C9) and 1,5-bis(3-chlorophenyl)-1,4-pentadiene-3-one (C10) can inhibit the bacteria of MTB at the concentration of 500 μg/ml using MGIT method. Based on MABA method, it can be obtained similar MIC value of C9 compound and C10 compound that are 187.5 μg/ml.Conclusion: C9 and C10 have antituberculosis activity. Benzylideneacetone analog of curcumin which has chlor moiety has a better activity in inhibiting MTB, but it still needs further research to make it become a potent antituberculosis drug.
ANTIHYPERLIPIDEMIC PROPERTY OF BOERHAVIA DIFFUSA LEAF EXTRACT IN STREPTOZOTOCIN-INDUCED DIABETIC RATS
Authors: Ccs Vasundhara , Devi S Gayathri
Published: April 2018

Objectives: The aim of the present research was to evaluate the antidiabetic, hyperlipidemic, and histopathological analysis in streptozotocin-induced diabetic rats (60 mg/kg body weight) using the ethanolic extract of leaves of Boerhavia diffusa (ELBD) (500 mg/kg body weight).Method: The rats were orally administered with the leaf extract for 45 days. Fasting blood was collected at the end of the experimental period by cardiac puncture to carry out the biochemical parameters, the organs such as liver, kidney, and pancreas were also excised to perform the histopathological analysis by fixing in 10% formalin solution.Results: Oral administration with the leaf extract resulted in decrease in the levels of blood glucose, with a concomitant increase in their body weight. The extracts also produced a significant decrease in the lipid levels when compared with the diabetic groups. Moreover, the extracts also exerted a favorable effect on the histopathological changes of liver, pancreas, and kidney.Conclusion: The results of the present study revealed that the ELBD possess antidiabetic and antihyperlipidemic properties. These effects may be due to the presence of bioactive components justifying its ethnomedical use.
THE INFLUENCE OF SUKSES BER-KB COUNSELING TOOL TO KNOWLEDGE OF ORAL CONTRACEPTIVE ACCEPTORS AT PHARMACIES IN MALANG
Authors: Pramestutie Hananditia R , Illahi Ratna K , S Perdanastuti Hidayah , L Hariadini Ayuk , H Lathifah
Published: April 2018

Objective: The use of oral contraceptive requires specific instructions. Pharmacist, as a part of healthcare provision, is able to counsel their clients about the proper use of oral contraceptive to be successful in family planning program. Pharmacist must be able to explain what acceptors should do if she misses pills and possible side effects because side effects are the most common reasons for women discontinuing combined oral contraceptive (COC). Therefore, counseling is an important part of family planning service. To provide more effective counseling, this study used “Sukses Ber-KB” computer application as a counseling tool. We aimed to determine the effect of this tool on improving the knowledge of oral contraceptive acceptors interviewed at pharmacies in Malang.Methods: Pharmacy selection was done by cluster random sampling based on the five districts of Malang, while acceptors were selected using a purposive sampling method, resulting in 106 COC acceptors. This study comprises pre-experimental research (one group pretest-posttest) with a cross-sectional study design, the analysis using Wilcoxon test.Results: The analysis of the results using a Wilcoxon test showed a significance value of 0 (p<0.05). The study sought to determine change in the contraceptive users knowledge scores about COC s following counseling with the Sukses Ber-KB counseling tool. The results also showed 105 positive score changes (increased knowledge) and 1 tie.Conclusion: It is concluded that the use of the Sukses Ber-KB counseling tool showed significant increase in the users’ knowledge about oral contraceptives with p<0.05.
ASSESSMENT OF ANTI-INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF ASAM KANDIS (GARCINIA XANTHOCHYMUS HOOK. F. EX T. ANDERSON) FRUIT
Authors: Winata Hanafis Sastra , Rosidah Rosidah , Sitorus Panal
Published: April 2018

Objective: The objective of this study was to evaluate the anti-inflammatory activity in acute and subacute models of inflammation from ethanolic fruit extract of Asam kandis (Garcinia xanthochymus Hook. f. ex T. Anderson) in animal (rats) models.Methods: Pleliminary phytochemical screening was carried out by using standard procedures.. Assessment of acute and subacute models of inflammation was using carrageenan-induced paw edema method and cotton pellet granuloma method using three dosage treatments; 200 mg/kg BW, 400 mg/kg BW, and 800 mg/kg BW along with a negative control group (0.5% Na CMC) and positive control (Na diclofenac 2.25 mg/kg BW). The inhibition period was observed at 30, 60, 90, 120, 150, and 180 min time intervals.Result: The phytochemical screening showed that the ethanolic fruit extract from Asam kandis contain contains flavonoids, glycosides, steroids, and triterpenoids. The anti-inflammatory result showed that the strongest inhibition produced by ethanolic fruit extract of Asam kandis occurred on the dosage of 800 mg/kg BW compared to the other doses (200 and 400 mg/kg BW) throughout the observation period.Conclusion: This finding indicated that ethanolic fruit extract of Asam kandis (G. xanthochymus Hook. f. ex T. Anderson) might become an interesting candidate for treatment of inflammation.
EVALUATION OF WARFARIN ORAL USED BY INTERNATIONAL NORMALIZED RATIO VALUE AND DETERMINATION FREQUENCY TO CARDIOVASCULAR PATIENT AT HAJI ADAM MALIK GENERAL HOSPITAL, MEDAN, INDONESIA
Authors: Pertiwi Dewi , Suwarso Edy , Manik Parlindungan
Published: April 2018

Objective: The objective of this research was to evaluate of warfarin oral used by value and determination frequency of international normalized ratio (INR).Methods: The data of cardiovascular patients were collected from medical records in Haji Adam Malik General Hospital, Medan, North Sumatera, Indonesia, in 2016. This study evaluated the data by retrospective study design. The sample study was selected by Slovin method from the population of medical record of cardiovascular patients who received warfarin therapy. The sample of population was divided based on how many times the INR was measured. The groups are no measurement, once a year, unregularly schedule, thrice a year, and every month. The data were analyzed by analysis of variant to evaluated association of INR values and groups of patients.Result: The total sample in this study was 90 patients based on Slovin formula. The percentage of patient who never gets INR checked was 18.89%, once a year was 32.2%, unregularly was 34.44%, thrice a year was 8.89%, and every month was 5.56%. The value of INR in groups was 0.00 ± 0.00 in never checked group, once in year was 1.18 ± 0.44, unregularly was 1.79 ± 1.00, once time in 3 months was 2.04 ± 0.73, and every month was 2.42 ± 0.91. The groups of patients with never evaluation of INR value were significantly different with the other groups (p≤0.05).Conclusion: The results obtained in this study indicated the majority patients group in case of warfarin oral used and evaluation of bleeding status were once checked in year and unregularly determination of INR value. The best condition, in this case, was the determination of INR value in every month caused the bleeding or coagulation status of patient can be evaluated.
THE ROLE OF GREEN TEA IN ORAL HEALTH – A REVIEW
Authors: Mohan Meenakshi , Jeevanandan Ganesh , Raja S Mithun
Published: April 2018

Tea is the most widely consumed and a popular beverage in the world. Over the past decade, molecular components of teas and their health benefits on humans have received increasing attention from researchers. Functional foods are foods with positive health benefits that extend beyond their normal nutritional value. They interrupt the functions of the body and help in the management of specific health conditions and preventing pathologic changes. One such nature’s gift is green tea. Green tea, a leading beverage in the Far East for the past thousand years, is an important source of polyphenol antioxidants. (EGCG) epigallocatechin 3 gallate, a polyphenol, constitute the most interesting components in green tea leaves. There is an increasing interest on the health benefits of green tea in the field of oral health. Green tea is renowned for its antioxidant, anti-cariogenic, anti inflammatory and antimicrobial properties. This traditional beverage is also used in the management of chronic systemic diseases including carcinoma. Recent studies has emphasized that in addition to the microbial activity, the host immuno-inflammatory reactions destroy the oral tissues to a greater extent. In such cases green tea is considered to be a natural preventive and curative agent. There is a growing search of evidence for understanding the beneficial role of green tea and its polyphenols in oral health. Numerous studies have shown the beneficial effects on the regular intake of green tea in maintaining oral health. Even though studies demonstrate the health effects of green tea polyphenols, more clinical and biological studies to support guidelines for green tea intake as part of prevention and treatment of specific oral pathologies are needed.
ESTIMATION OF TOTAL FLAVONOID, PHENOLIC CONTENT, AND FREE RADICAL SCAVENGING POTENTIAL OF GLYCYRRHIZA GLABRA ROOT EXTRACT
Authors: S Velvizhi , S Annapurani
Published: April 2018

Objective: The present study attempts to estimate the total flavonoid and phenolic content and to evaluate the free radical scavenging activity of the roots of Glycyrrhiza glabra Leguminosae family.Methods: The various extracts, namely, petroleum ether, chloroform, ethyl acetate, aqueous, and methanol of G. glabra root were evaluated by 2, 2-diphenyl-1-picryl-hydrazyl (DPPH), hydroxyl radicals, superoxide, 2,2’-azino-bis-3-ethyl benzthiazoline-6-sulphonic acid (ABTS), and non-radicals such as hydrogen peroxide (H2O2) and nitric oxide (NO) and assays. Total flavonoid and phenol contents were estimated as per the standard procedure.Results: The effect of the methanolic extract of G. glabra root was found to be more in scavenging the free radicals such as DPPH, hydroxyl, H2O2, superoxide, NO, and ABTS when compared to other extracts. The presence of flavonoids and phenol in the plant is responsible for the free radical scavenging effects.Conclusion: This in vitro assessment of the antioxidant properties of the various extracts of G. glabra roots validates and confirms its free-radical scavenging activity. Thus, the present data suggest that the G. glabra root extract can be used as a good source of natural antioxidants for health benefits.
IN VIVO RADIOPROTECTIVE EFFECTS OF WHEATGRASS (TRITICUM AESTIVUM) EXTRACT AGAINST X-IRRADAITION-INDUCED OXIDATIVE STRESS AND APOPTOSIS IN PERIPHERAL BLOOD LYMPHOCYTES IN RATS
Authors: Shyam Chandresh , Dhawan Devinder K , Chadha Vijayta D
Published: April 2018

Objectives: The present study was undertaken to investigate the possible protective potential of wheatgrass extract against radiation-induced toxicity in peripheral lymphocytes of rats exposed to a fractionated dose of X-rays.Methods: Effects of the X-irradiation with and without wheatgrass were studied on various parameters in peripheral lymphocytes including antioxidant defense system and apoptosis. Male Sprague-Dawley rats were divided into four different groups: Normal control group, X-ray-irradiated group (21 Gy over a span of 7 days), wheatgrass-treated group (80 mg/100 g bodyweight for 2 weeks), and X-rays-irradiated + wheatgrass-treated group. All the biochemical indices which included lipid peroxidation (LPO), reduced glutathione, reactive oxygen species (ROS), and activities of antioxidant enzymes were investigated in lymphocytes. Terminal deoxynucleotidyl transferase dUTP nick-end labeling assay was carried out to assess the apoptosis in lymphocytes following whole-body X-irradiation.Results: Whole-body X-irradiation to rats resulted in significant increase in LPO with concomitant depression of antioxidant enzymes activities, namely, superoxide dismutase, catalase, and glutathione peroxidise (GPx) in lymphocytes. Further, the present study witnessed a significant increase in the number of apoptotic lymphocytes in the X-irradiated animals. However, wheatgrass supplementation lowered the LPO levels, restored cellular antioxidant status, and provided significant protection against radiation-induced apoptosis.Conclusions: Based on these observations, the present study suggests that wheatgrass extract has the potential to be used as an effective radioprotectant against radiation-induced oxidative stress and apoptosis in peripheral lymphocytes of whole-body X-ray-exposed rats.
A CLINICAL STUDY ON MANAGEMENT OF POST-OPERATIVE PAIN AND QUALITY OF LIFE OF OSTEOARTHRITIS PATIENTS AFTER TOTAL KNEE ARTHROPLASTY
Authors: T Tamilslevan , H Kalaivani
Published: April 2018

Objective: The objective of this study is to assess the effect of pregabalin in the management of post-operative pain and the quality of life (QOL) of osteoarthritis (OA) patients after total knee arthroplasty.Methods: This prospective observational study was conducted in the Department of Orthopedics. A total of 96 patients were divided into two groups. Group A consists of 50 patients with the treatment of nonsteroidal anti-inflammatory drugs (NSAIDs) and Group B consists of 46 patients with the treatment of pregabalin with NSAIDs. The study subjects were followed once in 60 days for 6 months, and they were asked to answer the visual analog scale (VAS) and knee injury and OA outcome score (KOOS) questionnaire. The effect of the treatment was assessed by comparing the baseline score with follow-up score.Results: Our study result showed that the pain score of Group B in VAS at 2nd follow-up was 2.56±0.34 and KOOS pain score was 92.73±3.45 (p<0.01). The QOL score was improved significantly to 81.56±5.29 (p<0.01) as compared to Group A.Conclusion: The study concluded that pregabalin with NSAIDs group patients showed a better improvement in pain, symptoms, and QOL within short duration as compared to NSAIDs alone used group.
INHIBITORY EFFECT OF A STANDARDIZED HYDROETHANOLIC EXTRACT OF TERMINALIA ARJUNA BARK ON ALPHA-AMYLASE ENZYMEINHIBITORY EFFECT OF A STANDARDIZED HYDROETHANOLIC EXTRACT OF TERMINALIA ARJUNA BARK ON ALPHA-AMYLASE ENZYME
Authors: Shengule Sushant A , Mishra Sanjay , Bodhale Shweta
Published: April 2018

Objective: The present study was initiated to screen the hydroethanolic bark extract for α-amylase inhibitory activity and standardization of the Terminalia arjuna for polyphenolic phytochemicals using high-performance liquid chromatography-photo diode array (HPLC-PDA) method.Methods: The T. arjuna bark sample was extracted with ethanol: water (70:30 v/v) using Soxhlet extraction. A Dionex P680 HPLC system was used to acquire chromatograms. The screening of extract of T. arjuna bark has performed for in vitro α-amylase inhibitory assay. Each experiment was repeated 3 times. All values were expressed mean ± standard deviation.Results: The content of arjunetin, arjungenin, gallic acid, ellagic acid, and quercetin was 0.47, 8.22, 2.443, 7.901, and 3.20 mg/g, respectively, in a hydroethanolic extract of T. arjuna. The hydroethanolic extract of T. arjuna bark and acarbose has shown an inhibitory activity with an IC50 value 145.90 and 62.35 μg/mL, respectively.Conclusion: The hydroethanolic extract T. arjuna bark demonstrates α-amylase inhibitory activity due to a synergistic effect of the phytochemical constituents present in it. This study suggests that one of the mechanisms of this plant for antidiabetic activity is through the inhibition of α-amylase enzyme.
FABRICATION AND EFFECT OF PROCESS VARIABLES OF SITAGLIPTIN MICROSPHERES
Authors: S Revathi , Md Dhanaraju
Published: April 2018

Objective: The study is to formulate and assess the effects of different variables on the release profile of sitagliptin microspheres.Methods: The microspheres were prepared by emulsion-solvent diffusion method and ionotropic gelation method using ethyl cellulose and sodium alginate as the polymers, respectively. The formulations are optimized by applying 23 factorial design based on the drug-polymer ratio, stirring speed, and method of preparation.Results: The drug-polymer interaction was checked by the Fourier-transform infrared spectroscopy and differential scanning calorimetry the results of which indicated no incompatibility. The formulated sitagliptin microspheres were evaluated for shape, morphology, particle size, the degree of swelling, encapsulation efficiency, in vitro drug release studies for 12 h, and kinetics of drug release.Conclusion: The results showed that the drug-polymer ratio and stirring speed affected the particle size and drug release. The release of the drug was found to be sustained, and diffusion path is following cube root law of Hixson-Crowell kinetics. The batch F3 was found to be desirable and was further characterized by scanning electron microscope for morphology.
CURRENT PHARMACOLOGICAL STATUS OF CARDIOPROTECTIVE PLANTS AGAINST ISOPROTERENOL INDUCED MYOCARDIAL INFARCTION
Authors: Fathima Syeda Nishat , Murthy S Vasudeva
Published: April 2018

Objective: Cardiovascular diseases are the major cause of morbidity and mortality in the modern era. Myocardial infarction is a condition where there is a significant decrease or block in the blood (oxygen) supply to the part of heart, leading to degeneration of a portion of the myocardium which triggers a cascade of cellular, inflammatory and biochemical events, leading eventually to the irreversible death (necrosis) of heart muscle cells. Various therapeutic interventions, including lifestyle modification, pharmacological treatment options, and surgical techniques are available. The present review focus on the plants that have been evaluated for cardioprotective activity against isoproterenol-induced myocardial infarction.Method: The current status of Cardioprotective plants was obtained from a literature search of electronic databases such as Google Scholar, Pubmed and Scopus up to 2017 for publications on medicinal plants used against isoproterenol-induced myocardial infarction. Isoproterenol, Isoprenaline, myocardial infarction, cardioprotective were used as keywords for the searching.Result: A total of 117 different plant parts and their extracts have till now been published to possess cardioprotection against isoproterenol-induced myocardial infarction. Isoproterenol a beta-adrenergic receptors agonist causes severe stress in myocardium resulting in the infarct-like lesion and produced cardiotoxic effects by elevating the levels of cardiac biomarkers and causing changes in ECG. Plant-based medicines with their antioxidant, antiapoptotic, antihyperlipidemic, platelet antiaggregatory, anti-lipid peroxidation property provide substantial evidence for the management of Ischemia.Conclusion: This review, therefore, provides a useful resource to enable a thorough assessment of the profile of plants that have cardioprotective activity against isoproterenol-induced myocardial infarction.
EXPRESSION OF TRANSFORMING GROWTH FACTOR ALPHA BAMHI AND RSAI GENE VARIANTS ASSOCIATED WITH NON-SYNDROMIC CLEFT PALATE OF INDONESIAN SUBJECTS USING POLYMERASE CHAIN REACTION METHOD
Authors: Melani Maskoen Ani , L Nasroen Saskia , Nanda Fauziah Prima , Setiawan Soeria Soemantri Eky , A Gani Basri
Published: April 2018

Objective: This study aimed to detect and analyze transforming growth factor alpha (TGFA) BamHI and RsaI gene variants which associated with the risk factor of non-syndromic cleft palate only (NS CPO) of Indonesian subject.Methods: This was case-control study using samples from 32 NS CPO subjects and 28 control subjects. DNA was extracted from venous blood, and the TGFA gene was amplified using polymerase chain reaction technique, then digestion product from TaqI and RsaI restriction enzyme was evaluated. Statistical analysis to determine significant differences of gene variant frequency among NS CPO subject and control was χ2. The odds ratio (OR) was used to determine a risk factor of NS CPO.Results: The study results showed that the TGFA BamHI gene variant was not identified in NS CPO among Indonesian but TGFA RsaI gene variant was identified. The frequency of TT/B1B1 homozygous mutant genotype was 80.0% in NS CPO subjects and 20.0% in control subjects (OR=3.857; 95% confidence interval=0.405–36.749).Conclusion: TGFA RsaI gene can be considered a risk factor of NS CPO compared TGFA BamH1 gene of Indonesian subjects.
GENERATION OF REACTIVE OXYGEN SPECIES IN RAT EPIDIDYMAL SPERMATOZOA AFTER CYCLOPHOSPHAMIDE TREATMENT
Authors: Zn Kashmiri , Ms Sastry
Published: April 2018

Objective: The aim of this study was to examine the effect of an anticancer drug cyclophosphamide (CPA) on generation of reactive oxygen species (ROS) in epididymal spermatozoa of Wistar rat, Rattus norvegicus. Methods: For this purpose, the rats were injected intraperitoneally with different doses of CPA (5 mg, 15 mg, and 20 mg/Kg BW for 2 weeks).Results: Treatment resulted into significantly increased level of ROS in CPA-treated groups when compared to the vehicle-treated control group.Conclusion: The results revealed that CPA has deleterious effect on the sperm morphology and physiology, which is dose and duration dependent and at certain doses cause the production of a number of reactive molecules and free radicals derived from molecular oxygen consequently resulting into adverse effect on the sperm function and hence on reproduction.
INVESTIGATION OF KONDAGOGU GUM TO DEVELOP TRANSDERMAL FILM OF REPAGLINIDE
Authors: Srikanth Reddy Poreddy , Subhash Chandra Bose Penjuri , Sruthi Vuppula , Saritha Damineni
Published: April 2018

Objective: In the present study, an attempt was made to develop polymeric blend transdermal patch of repaglinide using hydroxypropyl methyl cellulose (HPMC) K4M and kondagogu gum.Methods: A series of repaglinide drug-incorporated HPMC K4M-kondagogu gum matrix films were prepared by solvent casting method. The prepared transdermal films were evaluated for various parameters such as thickness, tensile strength, folding endurance, % elongation, % moisture content, % moisture uptake, % drug content, in vitro drug release, and drug excipient compatibility.Results: The Fourier-transform infrared spectra of the pure drug as well as drug-incorporated formulation indicated that no chemical interaction occurred between the drug and the polymers used. Differential scanning calorimetry thermograms of the pure drug and prepared formulation indicated that the drug has dispersed in micron level in the prepared films. In vitro release study data of prepared formulations were fitted into various mathematical models, and the best-fit model was found to be Higuchi model.Conclusion: Among all the formulations studied, the formulation F4 was found to be an optimized composition for efficient transdermal delivery of repaglinide for 24 h study period. Stability studies of the drug formulations concluded that the drug was stable in the optimized formulation for the study period.
PREPARATION AND CHARACTERIZATION OF NANOCRYSTALS FOR SOLUBILITY AND DISSOLUTION RATE ENHANCEMENT OF PALIPERIDONE USING DIFFERENT HYDROPHILIC CARRIERS: IN VITRO-IN VIVO STUDY
Authors: Rajkumar Moon , Surendra Gattani
Published: April 2018

Objective: The objective of this study was to increase the solubility and dissolution rate of paliperidone (PAL) by preparing its nanocrystals using different hydrophilic carriers by antisolvent precipitation technique.Methods: The nanoparticles (NP) were characterized for aqueous solubility, drug content, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction, scanning electron microscopy, particle size, and in vitro-in vivo analysis.Results: The results showed improved solubility and dissolution rate of NPs when compared to pure drug and physical mixture (PM). Solubility data showed a linear graph giving an indication that there is a gradual increase in the solubility profile of the drug with an increase in concentration of the carriers. At highest concentration, the solubility of NPs with Plasdone S630, Povidone K-25, and PVP K-30 found to be increased by 12 folds, 9 folds and 6 folds, respectively, as compared to pure drug. The release profile of NPs with Plasdone S630 in terms of dissolution efficiency at 60 min (DE60), initial dissolution rate (IDR), amount release in 15 min (Q15 min), and time for 75% release (t75%) shows better results when compared to pure drug, PM, and also NPs with povidone 25 and povidone 30. In vivo study reveals that optimized NPs elicited significant induction of cataleptic behavior which is the indication of antipsychotic agent(s) effect.Conclusion: The process antisolvent precipitation under constant stirring may be a promising method to produce stable PAL NPs with markedly enhanced solubility and dissolution rate due to nanonization with the increased surface area, improved wettability, and reduced diffusion pathway.
A geriatria canina e o manejo das doenças neoplásicas: Revisão
Authors: Da Motta Amanda , Kinappe Letícia , Duhart Daniele , Motta Amanda de Souza da
Published: April 2018

Some changes in population habits have had an important impact on pet care. A greater approximation of owner-animal is observed, which has made dogs and cats incorporated into the family. In the same way, Veterinary Medicine has been developing in the most different areas, and veterinary oncology has been emphasizing with the new approaches. Neoplasms, in general, exhibit considerable variation in their semiologic, clinical and histological aspects and for these reasons, predictions of tumor behavior and responses to treatment may be extremely difficult and subjective. The fact that the dogs are reaching the greater age has predisposed to the appearance of these diseases with more frequency, being possible the study of these etiologies with more detail. Therefore, this review seeks to deepen questions related to canine geriatrics and the consequences of the greater age of dogs with the appearance of neoplasms. The relevant aspects on the etiology of neoplasms, their main complications and their management will be approached, considering the new therapies adopted today, as well as the observed relationship between the owners and their pets.
GEOELECTRICAL MODEL FOR AQUIFER IN THE BONITA LAKE REGION, PLANALTINA, DISTRITO FEDERAL, BRAZIL
Authors: Tadeu Carvalho do Nascimento Carlos , Elias Bernardi José Vicente , De Almeida Andreia , Magalhães João Cândido , Barbosa Landim Paulo Milton
Published: April 2018

ABSTRACT. The aim of this study was to analyze the soil geoelectric behavior, through geophysical surveys, in the surrounding region to Bonita Lake, a natural reservoir located in the Ecological Station águas Emendadas (ESECAE), 50 kilometers from Brasília (Brazil). Sixteen vertical electrical sounding (VES) were performed with Schlumberger array. The geoelectrical model, obtained by inversion of the field data and statistical analysis of the inverted data, indicated structure with superficial dry soil above partially saturated layer, and finally a soil or rock with low permeability, related to the aquifer formation with varying thickness, about ten meters below the lake and up to twenty meters deep in the surrounding area. The VES showed that the aquifer has great lateral extension to the north, east and west of the lake; providing water to the same, while in the south, the aquifer is possibly limited by quartzites of the Canastra Group. This restriction can result in the absence of aquifer recharge in the southern portion, and coincides with the region where the lake drains into the source of Mestre D’Armas stream. This information is important because it can be used in the delineation of the hydrogeological basin and the Bonita Lake protection perimeter. Keywords: Ecological Station of águas Emendadas, aquifer, geophysics, vertical electrical soundings. RESUMO. O objetivo deste estudo foi analisar o comportamento geoelétrico do solo, por meio de levantamentos geofísicos, na região circundante à Lagoa Bonita, um reservatório natural localizado na Estação Ecológica de águas Emendadas (ESECAE), a 50 quilômetros de Brasília (Brasil). Dezesseis sondagens elétricas verticais (SEV) foram realizadas com arranjo de Schlumberger. Os modelos geoelétricos, obtidos pela inversão dos dados de campo e análise estatística dos dados invertidos, indicaram uma estrutura com solo superficial seco sobreposto a uma camada parcialmente saturada e, por fim, um solo ou rocha com baixa permeabilidade, referente a formação aquífera, com espessura variável, cerca de dez metros abaixo da lagoa e até vinte metros de profundidade na área circundante. As SEV demonstraram que o aquífero possui grande extensão lateral para norte, leste e oeste da lagoa; fornecendo água para a mesma, enquanto que, na direção sul, o aquífero é possivelmente limitado por quartzitos do Grupo Canastra. Esta restrição pode resultar na ausência de recarga do aquífero na porção sul, e coincide com a região onde a lagoa drena para a nascente do ribeirão Mestre D’Armas. Esta informação é importante, pois pode ser utilizada no processo de delimitação da bacia hidrogeológica e delimitação do perímetro de proteção da lagoa Bonita.  Palavras-chave: Estação Ecológica de águas Emendadas, aquífero, geofísica, sondagem elétrica vertical.
Addendum to: On a simultaneous generalization of β-normality and almost normality
Authors: Das A.K. , Bhat Pratibha , Tartir J.K.
Published: April 2018

In [1], the authors prove that almost ?-normality is preserved by continuous,
open, closed surjections. We present examples to show that neither ?open?
nor ?closed? can be omitted.
Some existence of coincidence point and approximate solution method for generalizedweak contraction in b-generalized pseudodistance fiunctionsy
Authors: Mongkolkeha Chirasak , Kumam Poom
Published: April 2018

The purpose of this article is to prove some coincidence point and
approximate solution method for generalized weak contraction mapping in
b??metric spaces by using the concept of b-generalized pseudodistance. Also,
we give some examples to illustrate our main results.
Topological semigroups and their prequantale models
Authors: Zhao Bin , Xia Changchun , Wang Kaiyun
Published: April 2018

In this paper, we introduce a condition (?) on topological semigroups, and
prove that every T1 topological semigroup satisfying condition (?) has a
bounded complete algebraic prequantale model. On the basis of this result,
we also show that every T0 topological semigroup satisfying condition (?)
can be embedded into a compact and locally compact sober topological
semigroup.
On pseudo-slant submanifolds of a Sasakian space form
Authors: Dirik Süleyman , Atçeken Mehmet , Yıldırım Ümit
Published: April 2018

In this paper, we study the geometry of the pseudo-slant submanifolds of a
Sasakian space form. Necessary and sufficient conditions are given for a
submanifold to be pseudo-slant submanifolds, pseudo-slant product, mixed
geodesic and totally geodesic in Sasakian manifolds. Finally, we give some
results for totally umbilical pseudo-slant submanifolds of Sasakian
manifolds and Sasakian space forms.
BUILDING COMPETITIVENESS WITH ICT: NEW HORIZONS FOR INVESTMENT OF GLOBAL BUSINESS
Authors: Kibalnyk Liubov , Pasenko Vladislav
Published: April 2018

The article explores the features of the ICT-sector as a modern driver of world economic development. The indicators of development of international trade in ICT services are analyzed. The regional features of the development of ICT in the world are determined. The internal indicators of the development of the ICT market are investigated.
PROGRAM BIMBINGAN UNTUK MENINGKATKAN MOTIVASI BELAJAR SISWA
Authors: Ismaniar Ismaniar Ismaniar
Published: April 2018

The present study is aimed at developing effective guidance program for increasing student’s learning motivation. The present study applies quantitative research approach with nonequivalent pre-posttest control group quasi-experimental design, and nonrandom-purposive sampling technique. The data were collected using inventory, interview, and documentary study. The study comes up with the main finding that the tested guidance program is proven to be effective for increasing learning motivation students of 11th grade at SMA Kartika XIX-2 Bandung.
Sociedade pedagógica e as transformações nos espaços-tempos do ensinar e do aprender
Authors: Camozzato Viviane
Published: April 2018

Problematiza algumas das transformações nos espaços-tempos do ensinar e do aprender, pensando em possíveis articulações entre as mudanças produzidas pela modernidade líquida e o que vem sendo denominado – entre outros termos – de sociedade pedagógica. O corpus é composto por porções das obras Pedagogia, de Lorenzo Luzuriaga, Introdução à Pedagogia, de Émile Planchard, e A sociedade pedagógica, de Jacky Beillerot. Sugere que houve expansão dos domínios da pedagogia, proliferando sua atuação para além das paredes escolares e possibilitando que infindáveis lugares sejam alçados à condição de ensinantes.
Tempo, espaço e conhecimento nas escolas rurais (multi)seriadas e transgressão ao modelo seriado de ensino
Authors: Hage Salomão , Reis Maria Izabel
Published: April 2018

O trabalho dos docentes nas turmas e escolas rurais (multi)seriadas caracteriza-se pela precarização e pelo protagonismo. Eles resistem às situações adversas que configuram os processos educativos produzidos, em grande medida, pelo descaso e abandono do poder público e pela hegemonia da aplicação do modelo seriado como forma de organização do ensino. Os estudos e ações de formação realizados pelo Grupo de Estudo e Pesquisa em Educação do Campo na Amazônia (Geperuaz) motivam a discussão sobre o controle dos tempos/espaços/conhecimentos imposto pelo modelo seriado de ensino, como base da hegemonia desse modelo nas experiências das turmas e escolas rurais (multi)seriadas. Há sinais que convergem para o enfrentamento e a desconstrução dessa hegemonia e para a transgressão da matriz social, cultural, territorial e educacional que constitui a (multi)série.
Os objetivos das ações afirmativas em uma Instituição de Ensino Superior (IES) pública brasileira: a percepção da comunidade acadêmica
Authors: Albuquerque Rosa Almeida , Pedron Cristiane Drebes
Published: April 2018

Estudo de caso único realizado em uma Instituição de Ensino Superior (IES) federal brasileira. Analisa os objetivos das ações afirmativas nessa instituição com base na percepção de sua comunidade acadêmica. Utiliza o Value-focused Thinking, de Keeney, na abordagem dos objetivos e valores subjacentes às ações afirmativas da IES. Mediante entrevistas em profundidade, análise de documentos e observação direta, foi elaborada uma rede dos objetivos dessas ações afirmativas. O estudo contribui com um tema pouco explorado na academia brasileira, apoiado em uma teoria do campo da estratégia e da tomada de decisão, que enfatiza os valores dos stakeholders para a definição dos objetivos de uma organização.