bluuebunny/crossref_metadata_2025 huggingface dataset:
Análisis de heurísticos y sesgos cognitivos en las predicciones deportivas. Irracionalidad en las predicciones
Authors: Pérez Martínez Armenio , Rodríguez Fernández Aimara
Published: January 2025

El objetivo de este artículo es analizar la presencia de heurísticos y sesgos cognitivos que afectan la predicción de resultados deportivos, a partir de la aplicación de un experimento de orientación teórica diseñado para tal fin. Para ello, se utiliza una metodología cuantitativa, y se diseña un pre-experimento teóricamente orientado, basado en la formación de tres grupos muestrales aleatorios, utilizando un reactivo previamente diseñado. Participaron 264 estudiantes universitarios, divididos en tres grupos. Para analizar los resultados, se utilizó el estadístico Chi Cuadrado, el análisis del tamaño del efecto, así como el análisis porcentual mediante histogramas y la moda. Los resultados estadísticos muestran que, al comparar los resultados de los estudios, es evidente la presencia de sesgos cognitivos heurísticos y aspectos emocionales en las predicciones deportivas. Los resultados apuntan a un exceso de confianza en los conocimientos previos, la experiencia y la intuición, una infravaloración de la información estadística y una influencia de los componentes afectivos en las decisiones de predicción deportiva.
Efectos del discurso legal-institucional para el acceso al mercado laboral del migrante en condición irregular en Colombia
Authors: Buitrago Escobar Adriana Maria , Bravo Gonzalez Stefanny , Quintero Calvache Juan Carlos
Published: January 2025

Los sujetos que transitan por procesos migratorios quedan expuestos a los efectos que generan discursos de distinto orden que se producen en el territorio de llegada. Se procura determinar que el discurso institucional contenido en las leyes laborales para migrantes en condición irregular en Colombia, presiona la identidad de los migrantes irregulares y limita su acceso al mercado laboral. Al mismo tiempo que escatima el reconocimiento de las garantías laborales. Las teorías discursiva y narrativas de la identidad, constituyen el sustrato epistemológico, en el marco de una investigación de enfoque cualitativa, de forma pura, básica o fundamental, de tipo documental y bajo el método sintético, de donde se logra identificar que las normas laborales que regulan el acceso al mercado laboral transforman la identidad del migrante y lo reduce a una entidad carente de las garantías del pleno empleo.
Rhetoric in Modern Biological Thought: A Case Study of Classical Genetics
Authors: Pereira Martins Lilian Al-Chueyr
Published: January 2025

This paper mainly focuses on the book The Mechanism of Mendelian Heredity (1915) by T. H. Morgan (1866-1945), Alfred H. Sturtevant (1891-1970), Herman J. Muller (1890-1967), and Calvin B. Bridges (1889-1938). Considered by some as a landmark in genetics, it convinced specialized and not specialized at the time that the theory was established despite its crucial problems. It aims to discuss the rhetorical devices the authors used to persuade these people. The methodology comprises the analysis of primary sources, in addition to the text by Morgan et al. (1915), and secondary sources dealing with the topic, including some works by the author of this article related to the subject and its representation in science. The study concluded that Morgan et al. (1915) used their discourse, some drawings, and diagrams, unaccompanied by photographs, mainly in aspects of the theory where evidence was scarce, giving a false impression that all was clear. It is possible to find historical simplification of the facts to reinforce the authors’ arguments, lack of discussion of alternative explanations, diagrams representing ideal objects they did not observe, and theoretical examples that conflicted with the numerical data in their previous papers. In addition, they did not present problems or difficulties related to their theory. All this contributed to some problematic features of the theory not being evident and being accepted.
Educación superior e inclusión: un estudio de caso de Responsabilidad Social Universitaria
Authors: Brunal Schoonewolff Carolina , Ortegón Polo Pierina , Rodríguez Albor Gustavo
Published: January 2025

La educación superior juega un papel fundamental en el desarrollo humano siendo un elemento fundamental para el logro de los Objetivos de Desarrollo Sostenible (ODS) consagrados en la Agenda 2030. Este articulo analiza, a manera de estudio de caso, las acciones de responsabilidad social universitaria realizadas por una universidad de carácter privado enfocadas a contribuir al desarrollo humano, la inclusión social y el acceso a la educación. Para ello, se realizan entrevistas semiestructuradas a funcionarios de una institución universitaria y a expertos internacionales. Además, se revisan información cuantitativa de acciones realizadas por la IES alineadas a los ODS. Los resultados indican que este tipo de instituciones privadas no solo pueden aportar al cumplimiento de la Agenda 2030, sino que como universidades pueden agregar valor en el desarrollo humano desde sus tres funciones misionales educación, investigación y extensión.
Uma análise da apicultura do Rio Grande do Norte sob a ótica sustentável dos objetivos do desenvolvimento sustentável
Authors:   , Dantas Daura Helena Jales
Published: January 2025

A Organização das Nações Unidas (ONU), em 2015, estabeleceu a Agenda 2030, composta por dezessete objetivos voltados para o alcance do desenvolvimento sustentável, a sociedade e particularmente os sistemas produtivos deveriam orientar suas ações para o atendimento dos objetivos. Nesse contexto, esta pesquisa se debruça em como o sistema produtivo da apicultura dialoga com as ODS (Objetivos do Desenvolvimento Sustentavel). A apicultura é um campo produtivo que tem em sua natureza os princípios da sustentabilidade e também por ser uma das expressões produtivas da agricultura familiar que também produz com tal perspectiva. No entanto, para determinar em que medida a apicultura atende às metas das ODS, é necessário examinar mais de perto as práticas específicas dentro da apicultura, considerando fatores ambientais, inclusão social, e impacto econômico ao longo da cadeia de valor apícola. Assim, o trabalho tem por objetivo analisar como as atividades da apicultura no Rio Grande do Norte dialogam com os Objetivos de Desenvolvimento Sustentável (ODS). Como objetivos específicos propõe identificar quais dos ODS estão mais presentes nessa estrutura produtiva, econômica e social, além de analisar sobre como esses apicultores potiguares se comportam com relação a questões como a sustentabilidade ambiental, socioterritorial e econômica. Do ponto de vista metodológico foram entrevistados onze apicultores das quatro mesorregiões do Rio Grande do Norte (leste potiguar, agreste potiguar, central potiguar, oeste potiguar) utilizando o critério de exaustão para definir o número de entrevistados em cada região. As categorias de análise concentram-se em três eixos: socioeconômicos, culturais e ambientais da agricultura familiar do relatório da FAO (Organização para Alimentação e Agricultura da Organização das Nações Unidas) e as ODS propostas pela ONU. A análise dos dados revelou que a apicultura dialoga com as ODS pois trata-se de uma atividade produtiva norteada pelos princípios da sustentabilidade nas dimensões económicas, sociais e ambientais. Foi identificada a existência de temas transversais, como categorias emergentes entre as ODS que dialogam com a apicultura, são eles: Políticas Publicas, Governança, Sustentabilidade, Pluralidade e Produção. A materialização das ODS encontra como principais obstáculos o excesso de burocracia nos processos de comercialização e a descontinuidade das políticas públicas.
In-vitro, In-silico Investigations Reveals Potential Cytotoxic Activity of Fermentation Metabolites from Actinomycetes Isolated from Lonar Soda Lake Against HeLa Cancer Cell Lines
Authors: Bawane Pradip , Yele Santosh
Published: January 2025

Background:

Actinomycetes, Gram-positive bacteria, are recognized for producing
bioactive metabolites. Lonar Soda Lake, an alkaline ecosystem, hosts diverse actinomycetes with
possible anticancer activities.

Aim:

To assess the cytotoxic potential of fermentation metabolites from actinomycetes isolated
from Lonar Soda Lake against HeLa cancer cells employing in-vitro and in-silico methods.

Objectives:

Evaluate the cytotoxicity of fermentation metabolites from Lonar Lake actinomycetes
on HeLa cells. Execute molecular docking to forecast metabolite connections with cancer-related
proteins.

Materials and Methods:

The actinomycetes were isolated from the sediment sample of Lonar
Lake using a selective medium and recognized by gene sequencing. Cytotoxicity on HeLa cells
was assessed using the MTT assay, in consort with oxidative stress and apoptotic markers (GSH,
MDA, TNF-α, and caspase 3). Molecular docking and molecular dynamics studies evaluated
metabolite binding to cancer-related proteins (Bcl-2, TNF-α, caspase 3).

Results:

Fermentation metabolites of three Lonar Lake Sediment isolates (LLSD), LLSD-5, LLSD-
7, and LLSD-9 showing promising cytotoxic activity against HeLa cell lines by MTT assay, also
significantly modulate the oxidative stress parameters (GSH, MDA), and cell apoptotic marker
(TNF-α, caspase 3). IC50 values were 82.9 μg/ml (LLSD-5), 162.3 μg/ml (LLSD-7), and 20.15
μg/ml (LLSD-9). Furthermore, molecular docking displayed robust binding affinities to cancer-related
proteins, uncovering the possible mechanism of action.

Conclusion:

The fermentation metabolites actinomycete isolates from Lonar Lake exhibit significant
cytotoxic activity against HeLa cancer cell lines. Both in-vitro and in-silico analyses support
the potential of these metabolites as anticancer agents.
KDM4A Silencing Reverses Cisplatin Resistance in Ovarian Cancer Cells by Reducing Mitophagy via SNCA Transcriptional Inactivation
Authors: Xing Yan , Mao Meiya , Zhu Tianhong , Shi Hongyan , Ding Huiqing
Published: January 2025

Background:

Ovarian cancer is one of the deadliest gynecologic cancers,
with chemotherapy resistance as the greatest clinical challenge. Autophagy
occurrence is associated with cisplatin (DDP)-resistant ovarian cancer cells. Herein,
the role and mechanism of alpha-synuclein (SNCA), the autophagy-related gene, in
DDP resistance of ovarian cancer cells are explored.

Methods:

Differentially expressed genes in DDP resistance of ovarian cancer cells
were analyzed by GEO2R tools. DDP-resistant ovarian cancer cells (A2780/DDP)
were transfected and treated with 2.5 μg/mL DDP for 72 h, followed by the
determination of cell viability, proliferation, apoptosis, and expressions of SNCA, lysine
demethylase 4A (KDM4A), histone H3 lysine 9 trimethylation (H3K9me3), and
mitophagy-related proteins. The H3K9me3 demethylation of SNCA by KDM4A was
confirmed by chromatin immunoprecipitation.

Results:

SNCA and KDM4A were highly expressed in DDP-resistant ovarian cancer
cells and their parental cells. KDM4A knockdown diminished expressions of KDM4A
and SNCA and elevated H3K9me3 expression and H3K9me3 enrichment on SNCA
promoter in A2780/DDP cells. SNCA or KDM4A knockdown inhibited cell viability,
proliferation, and levels of LC3-II/LC3-I and Parkin while inducing cell apoptosis and
upregulating Cyt-C expression of A2780/DDP cells with/without DDP treatment;
however, SNCA overexpression not only did conversely but also reversed the effects
of KDM4A knockdown on DDP-treated A2780/DDP cells and vice versa.

Conclusion:

Silencing of KDM4A-mediated transcription inactivation of SNCA reduces
mitophagy, thus inhibiting the resistance of ovarian cancer cells to cisplatin. KDM4A
may be a promising drug target for DDP-resistant ovarian cancer cells.
Prognostic Value of Serum Bilirubin in Aneurysmal Subarachnoid
Hemorrhage Patients
Authors: Wang Ruoran , Luo Hongying , Xu Jianguo , He Min
Published: January 2025

Background:

Bilirubin plays a crucial role in the pathophysiological processes of
strokes. However, the relationship between serum bilirubin levels and the prognosis of aneurysmal
subarachnoid hemorrhage (aSAH) remains unexplored. This study aims to investigate the
association between serum bilirubin levels and the mortality rate of aSAH patients.

Methods:

695 aSAH patients were included to analyze the relationship between direct bilirubin
(DBil), indirect bilirubin (IDBil), total bilirubin (TBil), and mortality. The univariate and multivariate
logistic regression were conducted to discover risk factors for the mortality of aSAH. The
restricted cubic spline (RCS) was used to show the correlation between DBil, IDBil, TBil, and
mortality. A logistic regression predictive model was developed by incorporating significant factors
in the multivariate logistic regression. The receiver operating characteristic (ROC) curve was plotted
to evaluate the predictive value of serum bilirubin and the developed predictive model.

Results:

139 aSAH patients suffered death, with a mortality of 20.0%. Non-survivors had older
age (p =0.007), lower GCS (p <0.001), higher Hunt Hess (p <0.001), and mFisher (p <0.001).
Both DBil (p <0.001) and TBil (p =0.011) were significantly higher among non-survivors. While
the IDBil did not show a difference between survivors and non-survivors. The multivariate analysis
found age (p =0.111), Glasgow Coma Scale (p =0.005), white blood cell (p <0.001), glucose (p
=0.004), DBil (p =0.001), delayed cerebral ischemia (p <0.001) were significantly related with the
mortality of aSAH. A logistic regression predictive model for mortality was developed incorporating
these five factors, which had an area under the ROC curve (AUC) of 0.876. The AUC of DBil,
IDBil, and TBil for predicting mortality was 0.607, 0.570, and 0.529, respectively.

Conclusion:

Serum DBil level is positively associated with the mortality risk of aSAH. The predictive
model incorporating DBil is beneficial for clinicians to evaluate the mortality risk of
aSAH and adopt personalized therapeutics.
A Comprehensive Overview of the Chemistry and Biological Activities of
Flavonoids
Authors: Priya Muthiah Gnana Ruba , Priya Ratan , Mahesh Jahnavi , Dasappa Pooja , Murali Goutham , Shivanna Manoj , Solomon Viswas Raja
Published: January 2025

Flavonoids are a diverse group of naturally occurring compounds that can be found in
various foods, including berries, vegetables, cereals, bark, roots, stems, flowers, tea, and wine,
which contain polyphenol compounds. These natural compounds are renowned for their positive
impact on health, prompting endeavors to isolate these bioactive ingredients known as flavonoids.
Today, flavonoids are recognized as indispensable components in various domains, such as nutraceuticals,
pharmaceuticals, medicine, and cosmetics. This recognition stems from their potent
characteristics, including astaxanthin, anti-inflammatory, mutagen suppressor, and antineoplastic
qualities, and their capability to regulate prerequisite membrane localized enzyme activities. The
discovery of the correlation between flavonoid consumption and reduced cardiovascular mortality
rates, along with preventing coronary heart disease, has led to further research into their mechanisms
of action. Despite centuries of awareness regarding the broad biological activity of plant-
derived compounds, the precise working mechanisms of flavonoids remain incompletely understood.
In this review, we aim to explore current trends in flavonoid research and development, elucidate
their mechanisms of action, discuss their functions and applications, predict their potential
as drugs for cancer therapy, and outline potential avenues for future research.
Berberine Improves Glucose and Lipid Metabolism in Obese Mice through the Reduction of IRE1/GSK-3β Axis-Mediated Inflammation
Authors: Ding Lina , Xia Jingjing , Wang Hua , Qian Junyi , Jin Xiaodan , Yang Yang , Xia Jing , Shang Wenbin , Chen Ming
Published: January 2025

Introduction:

Berberine (BBR) has the characteristics of repressing hyperglycemia,
obesity, and inflammation, as well as improving insulin resistance. However, the underlying mechanism
remains to be fully understood. This study explores whether BBR regulates inositol requiring
enzyme 1 (IRE1)/glycogen synthase kinase 3 beta (GSK-3β) axis to resist obesity-associated
inflammation, thereby improving glucolipid metabolism disorders.

Method:

Mice were fed a high-fat diet and administrated with BBR, followed by measurement of
weight change, biochemical indicators, as well as glucose and insulin tolerance. Insulin-resistant
3T3-L1 adipocyte models were established, and the model cells were treated with BBR and IRE1
inhibitors. Cell viability was detected by cell counting kit-8 assay. Inflammatory factor secretion
and glucose consumption were measured via specific kits. Oil red O staining was used to observe
lipid droplet formation, and protein expressions in the IRE1/GSK-3β axis were determined via
Western blot.

Results:

BBR reduced weight, insulin resistance, levels of triglyceride, total cholesterol, free fatty
acid, high-density lipoprotein, and low-density lipoprotein but improved glucose tolerance in
obese mice. BBR and IRE1 inhibitors demonstrated no cytotoxicity. BBR and IRE1 inhibitors diminished
secretion of tumor necrosis factor-alpha, interleukin-6, and monocyte chemoattractant
protein 1, lipid droplet formation, and values of p-IRE1/IRE1 and p-GSK-3β/GSK-3β, but elevated
glucose consumption in insulin-resistant adipocytes.

Conclusion:

BBR improves glucose and lipid metabolism in obese mice through the reduction of
IRE1/GSK-3β axis-mediated inflammation, showing the great potential of BBR in reversing insulin
resistance in obesity.
Identification of Programmed Cell Death-related Biomarkers for the Potential Diagnosis and Treatment of Osteoporosis
Authors: Huo Yancheng , Guo Meng , Li Yihan , Yao Xingchen , Tian Qingxian , Liu Tie
Published: January 2025

Background:

Osteoporosis (OP) is a skeletal condition characterized by increased susceptibility
to fractures. Programmed cell death (PCD) is the orderly process of cells ending their
own life that has not been thoroughly explored in relation to OP.

Objective:

This study is to investigate PCD-related genes in OP, shedding light on potential mechanisms
underlying the disease.

Methods:

Public datasets (GSE56814 and GSE56815) were analyzed to identify differentially expressed
genes (DEGs). We employed the least absolute shrinkage and selection operator (LASSO),
Boruta, and random forest (RF) algorithms to pinpoint hub PCD-related genes in OP and construct
a predictive nomogram model. The performance of the model was validated through ROC
curve analysis, calibration curves, and decision curve analysis. Additionally, transcription factor
(TF) interaction analysis and functional enrichment analysis were conducted to explore the regulatory
networks and biological pathways involved.

Results:

We identified 161 DEGs, with 30 prominently associated with PCD. Five hub genes,
PDPK1, MAP1LC3B, ZFP36, DRAM1, and MPO, were highlighted as particularly significant. A
predictive nomogram integrating these genes demonstrated high accuracy (AUC) in forecasting
OP risk, with an AUC of 0.911 in the GSE56815 dataset. The validation confirmed the gene model
efficacy in differentiating OP risk and clinical applicability. The subsequent TF-gene interaction
analyses revealed that these hub genes are regulated by multiple TFs, indicating their central
role in OP pathology. Functional enrichment analysis of the hub genes indicated significant involvement
in apoptosis, autophagy, and immune response pathways.

result:

We identified 161 DEGs, with 30 prominently associated with PCD. Five hub genes, PDPK1, MAP1LC3B, ZFP36, DRAM1, and MPO, were highlighted as particularly significant. A predictive nomogram integrating these genes demonstrated high accuracy (AUC of 0.911 in dataset GSE56815) in forecasting OP risk. Validation confirmed the gene model's efficacy in differentiating OP risk and clinical applicability.

Conclusion:

This study identified PDPK1, MAP1LC3B, ZFP36, DRAM1, and MPO as potential
biomarkers and proposes a nomogram based on hub genes for predicting osteoporosis risk.
Improving Renal Protection in Chronic Kidney Disease Associated with Type 2 Diabetes: The Role of Finerenone
Authors: Nugroho Pringgodigdo
Published: January 2025

Chronic kidney disease (CKD) is a major complication of type 2 diabetes mellitus
(T2D), which often leads to diabetic kidney disease (DKD). Traditional therapies, including renin–
angiotensin–aldosterone system inhibitors and sodium–glucose cotransporter-2 inhibitors, are
effective in slowing CKD progression. However, these approaches are insufficient to comprehensively
inhibit mineralocorticoid receptor (MR) overactivation in the kidneys, which remains a significant
driver of inflammation, fibrosis, and oxidative stress. These pathological processes accelerate
kidney damage and cardiovascular complications. Finerenone—a nonsteroidal mineralocorticoid
receptor antagonist—represents a new frontier in renal protection. Unlike steroidal mineralocorticoid
antagonists (MRAs), finerenone offers a more selective MR blockade, reducing kidney
inflammation and fibrosis without significantly raising serum potassium levels. Landmark trials
have demonstrated the ability of finerenone to significantly reduce kidney and cardiovascular
events in patients with T2D and CKD. Clinical evidence has highlighted finerenone as an effective
option for slowing DKD progression while maintaining a favorable safety profile. Based on these
findings, recent guidelines have incorporated finerenone as a recommended therapy for patients
with T2D and CKD, emphasizing its role in reducing both renal and cardiovascular risks.
This review provides a comprehensive overview of the available data to offer a deeper understanding
of the potential of finerenone to transform CKD management for T2D patients.
Do SGLT2 Inhibitors Protect the Kidneys? An Alternative Explanation
Authors: Ilany Jacob
Published: January 2025

SGLT2 inhibitors are a family of drugs that were developed to treat diabetes mellitus.
In randomized controlled trials, SGLT2 inhibitors seem to prevent kidney deterioration in patients
with nephropathies, both diabetic and non-diabetic. However, in contrast to biochemical/physiological
results (proteinuria and serum creatinine levels) that improve in all studies, the clinical results
(all-cause mortality, cardiovascular death, need for dialysis, or renal transplant) do not consistently
improve. In this article, the author would like to suggest that SGLT2 inhibitors do not, in
fact, prevent the progression of renal diseases but rather alter laboratory results. This study will
present a theory that gives an alternative explanation for the findings in the studies that would explain
the above discrepancy between biochemical/physiological and clinical results. In general,
the author claims that SGLT2 inhibitors change the kinetics of renal creatinine and microalbumin
excretion but do not prevent parenchymal adverse changes in kidneys. This causes a dissociation
between renal function markers (such as serum creatinine level and urinary protein) and the real
kidney function. Thus, the clinical renal prognosis does not improve despite seemingly better laboratory
results.
Beyond Traditional Remedies: Blue Tansy Oil’s Progressive Approach to Acne
Authors: Goyal Mayuri , Singh Indu , Chauhan Shikha Baghel
Published: January 2025

Tansy oil, which is derived from the Tanacetum annuum plant, has shown great promise
as a therapeutic agent in aromatherapy and skincare because of its many uses. This study thoroughly
investigates the chemical makeup, extraction techniques, mechanisms of action, adjuvant qualities,
and incorporation of blue tansy oil into skincare regimens. Blue tansy oil's chemical profile reveals
the complexity of its composition, emphasizing important ingredients like myrcene, chamazulene,
sabinene, camphor, and others, each of which has a unique skincare advantage. The extraction
method of steam distillation is emphasized as a means of guaranteeing purity and potency. Differences
in composition resulting from growth site and extraction methods are also discussed. Comprehensive
knowledge of the therapeutic effects of blue tansy oil is made possible by insights into
the ingredients' mechanisms of action. One of the main ingredients, chamazulene, has strong antiinflammatory
properties. It is especially helpful in lowering the redness and inflammation linked to
acne. Beyond this, the oil's antibacterial, antioxidant, and analgesic qualities are enhanced by the
presence of sabinene, camphor, and myrcene. Blue Tansy oil has a broad range of adjuvant activities,
from antioxidant and calming benefits to anti-inflammatory and antibacterial qualities. Its potential
is investigated, offering chances for its incorporation into many therapeutic methods, including
support for skin health, stress relief, and scar reduction, among other benefits. The suggested
uses of blue tansy oil for skincare regimens include face masks, spot treatments, dilution, and
cleansing. It is important to conduct patch tests and follow recommended dosages to prevent negative
reactions. Upcoming research opportunities provide pathways for investigating pharmacological
impacts, safety characteristics, clinical effectiveness, formulation improvements, chemical analysis,
and comparative evaluations with alternative natural therapies. These studies seek to advance
our knowledge of the potential benefits of blue tansy oil and open the door for evidence-based
skincare and medical applications.
Chronic Obstructive Pulmonary Disease and Metabolic Syndrome
Authors: Pelin Uysal
Published: January 2025

Chronic obstructive pulmonary disease (COPD) is a clinical condition
characterized by progressive airflow limitation caused by an abnormal inflammatory
response of the lungs to harmful particles or gases that is not fully reversible. Smoking
is largely responsible for the development of the disease. Systemic inflammation
induced by smoking contributes to the natural history and clinical manifestations of
COPD by causing chronic heart failure, metabolic syndrome (MetS) and other chronic
diseases. MetS is a collection of interrelated clinical and biochemical disorders. MetS
includes abdominal obesity, elevated triglycerides and low high-density lipoprotein
(HDL) (atherogenic dyslipidemia), elevated blood pressure, insulin resistance,
prothrombotic and proinflammatory markers (elevated C-reactive protein (CRP),
fibrinogen, and other coagulation factors) with or without glucose intolerance. In
patients with COPD, one or more components of MetS may be present in comorbidities
that develop as a result of systemic inflammation. The prevalence of metabolic
syndrome in COPD patients was found to be 30% and the prevalence of type 2 diabetes
(T2DM) was found to be between 10-23%. Especially oral steroids used in the
treatment of COPD exacerbations increase the risk of T2DM. Treatment of MetS and
T2DM in patients with COPD does not differ.
Metabolic Syndrome and Polycystic Ovary Syndrome
Authors: Derya Aydın Sivri
Published: January 2025

Metabolic syndrome occurs at an early age in women with polycystic ovary
syndrome (PCOS), particularly among women with the highest insulin levels and body
mass index. Obesity is a common characteristic of PCOS and is more common in
women with PCOS. Excessive weight gain may reveal the latent PCOS condition. Most
women with PCOS are hyperinsulinemic and insulin-resistant. Insulin resistance (IR) is
a major cause of metabolic manifestations and is known to be a common finding in
PCOS. PCOS is also associated with an increased risk of impaired glucose tolerance,
type 2 gestational diabetes mellitus, lipid and lipoprotein abnormalities, and
nonalcoholic fatty liver disease. The presence of obesity, IR, impaired glucose
tolerance, diabetes mellitus type 2, and dyslipidemia may predispose to coronary heart
disease in women with PCOS.
An Alien Phenomenology in Dance: Virtual Telematic Performances as Embodied Philosophy
Authors: Strutt Dan
Published: January 2025

This article suggests that dance practice-led exploration of avatar embodiment and telematic performance in 3D virtual environments (such as those generated in real-time graphics engines) can be a meaningful mode of philosophical discovery—a mode of affective doing, creating, becoming, and embodied thinking. By exerting kinaesthetic agency and shared expression within corporeal forms that are both of our body and yet virtual as well as in avatar representations that do not necessarily correlate to our actual anatomical articulation, can we explore a new remote relationality of extended, non-human, or alien embodiment within virtual space? I explore the possibility that, if this experience is indeed philosophical, it can be expansive and joyous, critically and socially engaged, and even ethical in nature, despite the techno-political forces of capture and control which are understood to be at work in so-called volumetric regimes. To consider this I draw upon a proposed alignment of ideas from Ian Bogost (from “procedural rhetoric” to alien phenomenology) and from Laura Marks (unfolding-enfolding aesthetics and the “talisman image”) to think about virtual media forms that enhance dance’s inherent virtuality and its propensity for kinaesthetic metaphorism, ethical intersubjectivity, and play.
Da preparação à revisão: sem elas, não há publicação
Authors: Baggio Adriana Tulio
Published: January 2025

Resenha do livro: MORAES, Eugênio Vinci de. Processos de revisão textual. Curitiba: InterSaberes, 2020.
Representação feminina nas propagandas de cerveja
Authors: Rosa Acevedo Claudia , Akemi Kakiuthi Camila , Yukie Takagi Giovanna , Catão Bruno
Published: January 2025

Esta pesquisa tem como objetivo analisar o posicionamento das marcas de cerveja presentes no Brasil com relação à diversidade feminina e suas representações em comunicação nas publicações do Facebook. Como método, foi utilizado a análise de conteúdo, na qual foram selecionadas campanhas das marcas Skol, Heineken, Itaipava e Brahma, do período de 2015 a 2020. Buscamos verificar se a Skol, após sua polêmica campanha “Viva Redondo” de 2015, apresentou mudança em sua comunicação. Assim sendo, foi analisado também, o posicionamento das outras marcas para servirem como parâmetro de comparação, mostrando um declínio geral da sexualização da mulher na propaganda brasileira de cerveja.
Reflexes and Shared Intentionality in the Origins of Emotions Development: A Scoping Review of Studies on Blinking in Infants
Authors: Danilov Igor Val , Mihailova Sandra
Published: January 2025

This review aims to explore research on the development of emotions in organisms at the simple reflexes substage of the sensorimotor stage of cognitive development. We review the literature on alterations in spontaneous blinking in children under 6 months of age. Then, we extract the data from the selected studies that allow us to examine whether simple reflexes in infants reveal the emotion signature in the altered reflective responses. The significance of this study is that it is the first review to demonstrate that the affective cues cause altered blinking rates at birth. This study hypothesizes that emotion development begins with the association of affective cues with stimuli responsible for activating the neural pathways of simple reflexes—the mechanism of pre-perceptual multimodal integration. Our analysis posits that pre-perceptual multimodal integration can succeed because of shared intentionality in mother-child dyads. This emotion-reflex stimuli conjunction further develops these simple innate neuronal assemblies, shaping the emotional neuronal patterns in statistical learning that are continuously connected with the neuronal pathways of reflexes. The hypothesis of pre-perceptual multimodal integration converges the presumably opposing naturalist and constructivist viewpoints about emotional development.
Correction: Acceptability and Initial Adoption of the Heart Observation App for Infants With Congenital Heart Disease: Qualitative Study (Preprint)
Authors: Hjorth Johansen Elin , Børøsund Elin , Martinsen Østen Ingeborg , Holmstrøm Henrik , Moen Anne
Published: January 2025

UNSTRUCTURED
Efficacy and Compliance of a Working Memory Multitasking Task Digital Intervention for ADHD Children: a Pilot Study (Preprint)
Authors: Jung Minyoung , Woo Jimin , Kim Sungjin , Lim You Bin , Kim Younglae , Kang Dongwon , Min Jung-sang , Kim Bung-Nyun
Published: January 2025

BACKGROUND

Attention-Deficit/Hyperactivity Disorder (ADHD) is a prevalent neurodevelopmental disorder affecting 3-7% of children globally. Alternative treatments are needed to address the limitations of traditional pharmacotherapy and non-pharmacotherapy, such as drug side effects and substantial time and financial costs. In this light, digital therapeutics (DTx) for childhood ADHD are emerging as an effective alternative, with the benefits of potentially being free from serious side effects typical of software-based treatments and facilitating easy home use without constraints on time or space.

OBJECTIVE

This feasibility study aims to evaluate whether a 4-week digital treatment program can improve symptoms, problem behaviors, and neurocognitive functions in children with ADHD, independent of medication status, while also gauging their satisfaction with the program.

METHODS

We recruited 22 Korean children between the ages of 6-12 years with a diagnosis of ADHD. During the pre-intervention visit, we collected data on ADHD symptoms, relevant behavior scales, and neurocognitive assessments. Participants then used the program 5 times per day, 5 days a week, for 4 weeks at home. At the post-intervention visit, we collected the same data as during the pre-visit and gathered additional feedback on their experience over the 4-week period.

RESULTS

A total of 19 participants were included in the statistical analysis, showing significant decreases in scores across various categories. These include the Korean ADHD rating scale (K-ADHD-RS) total (P=.004), Inattentive (P=.004), Hyperactive/Impulsive (P=.011), Korean Conners parent rating scale (K-CPRS) total (P<.001), Impulsive-Hyperactive (P=.001), and Conduct ProblemⅠ (P=0.043). Significant improvements were also noted in the Stroop word (P=.004), color (P<.001), and color-word (P<.001) scores. Caregiver and child satisfaction surveys yielded mean ratings of 4.3 and 4.1 out of 5, respectively.

CONCLUSIONS

A four-week gamified intervention significantly improved attention and hyperactivity/impulsivity in children with ADHD, irrespective of medication status, demonstrating its effectiveness and acceptability as a treatment option.
Konseling gizi fertilitas terhadap pengetahuan, sikap, asupan makronutrien, dan berat badan pasangan program bayi tabung
Authors: Aritonang Sonia Marlaba , Mahdiah Mahdiah , Doloksaribu Tetty Herta , Doloksaribu Lusyana Gloria
Published: January 2025

The effect of fertility nutrition counseling on knowledge, attitude, macronutrient intake, and body weight couple in IVF programBackground: Based on PERFITRI (2017) shows 1,712 men and 2,055 women experiencing infertility. One of the factors that influences infertility is nutritional status. Overweight and underweight will affect conception delays. Body weight is influenced by nutritional knowledge, attitudes and food intake. Efforts to increase knowledge and attitudes can be done through nutritional counseling. Objective: This study aimed to analyze the effect of nutritional counseling on knowledge, attitudes, macronutrient intake, and weight of In Vitro Fertilization (IVF) couples at Halim Fertility Center. Methods: This research was a quasi-experiment with a one group pre-post test design. The study population was all married couples who were registered for nutritional counseling for the IVF program in January-February 2023 with a sample of 43 married couples. Data analysis used the T-dependent test and the Wilcoxon test. Results: The average value of knowledge and attitudes increased with an increase in the husband’s knowledge score of 37,70 and the wife’s score 29,95 and an increase in the husband’s attitude score of 19,30 and the wife’s score of 12,79. There was a decrease in the energy intake of the husband 10,23% and the wife 7,49%, the husband's fat intake was 35,69% and the wife was 28,62%, husband's carbohydrate intake was 9,45% and the wife was 12,90%. Protein intake increased 54,31% for husbands and 55,84% for wives. The average value of body weight decreased by 2,51 kg for husbands and 1,85 kg for wives. Conclusions: There is an effect of nutritional counseling on knowledge, attitudes, macronutrient intake and weight of IVF couples (p-value=0.000).
“ӨНГӨ” ХЭМЭЭХ МЭДЭГДЭХҮҮНИЙГ ТАНИН МЭДЭХ АСУУДАЛД
Authors: Т Булган , А Баасансүрэн
Published: January 2025

Буддын философийн танин мэдэхүйн судлалд мэдэгдэхүүн (phenomena) хэмээх ойлголт гол суурь эзлэх бөгөөд энэхүү суурь мэдэгдэхүүнийг танин барихын тулд юуны өмнө түүний мөн чанар, ялгалыг танин мэдэх, улмаар буй ба буй бус мэдэгдэхүүн, мөн ба биш хэмээх ойлголт, няцлага ба бүтээхүйн утга, нэг ба тус тус утга, шалтгаан ба үр дагавар, орон ба оронт, ерөнхий ба тусгаар, харшлах ба барилдах, бэлгэ чанар ба бэлгэдэлт, гурван цаг, өөрийн ба ерөнхий бэлгэ чанар, ном хаялцах арга ухаан, учир шалтгааны гаргалгаа, нотлолууд зэрэг танин мэдэхүйн олон аспектуудыг авч үздэг билээ.
Intensified Image Retrivel System :Non-Linear Mutation Based Genetic Algorithm
Authors: S. Senthilvel  , G. Thailambal
Published: January 2025

Globally, increasing amount of websites and data bases leads to utilization of enormous image data used in the system. The users interact with the images which are downloaded, stocked, uploaded and transmitting the data on regularly. Conversely, searching the particular images within the huge files and websites is the daunting problem. Traditionally, manual searching is not only time consuming but also less accurate process. Moreover, it requires the assistance of expertise for the image searching mechanism. To resolve the issue, an efficient IRS (Image Retrieval System) is needed for the users to automate the searching process. To address the issue, several conventional model attempted to achieve efficient IRS. However, existing researches limited in accuracy and speed. To overcome the limitations, proposed model utilized non-linear mutation updation based GA (Genetic Algorithm) for Reddit based IRS on eight classes. The GA is used for the capability of global optimization, parallelism and greater set of solution space. Nevertheless, it is sort by limited drawbacks such as unguided mutation, local extremum and convergence. To resolve the issue, non-linear mutation updation is added in the GA technique to improve the IRS efficiency. Moreover, VGG-16 algorithm is utilized for the feature extraction method to extract significant features from the data. Correspondingly, input data is acquired from the popular website called reddit which allows the users to upload and share images with the own post and comments of the users. The data is extracted through the API mechanism with the specific hashtag content.  The performance of the proposed model is calculated using performance metrics in order to evaluate the IRS efficacy. Moreover, internal comparison is processed in the respective research to reveals the better efficiency of the proposed model.
Innovative Computational Intelligence Frameworks for Complex Problem Solving and Optimization
Authors: Noorbhasha Junnu Babu  , Vidya Kamma  , R. Logesh Babu  , J. William Andrews  , Tatiraju.V.Rajani Kanth  , J. R. Vasanthi
Published: January 2025

The rapid advancement of computational intelligence (CI) techniques has enabled the development of highly efficient frameworks for solving complex optimization problems across various domains, including engineering, healthcare, and industrial systems. This paper presents innovative computational intelligence frameworks that integrate advanced algorithms such as Quantum-Inspired Evolutionary Algorithms (QIEA), Hybrid Metaheuristics, and Deep Learning-based optimization models. These frameworks aim to address optimization challenges by improving convergence rates, solution accuracy, and computational efficiency. In the context of healthcare, a Deep Learning-based optimization framework was successfully used to predict the optimal treatment plans for cancer patients, achieving a 92% accuracy rate in classification tasks. The proposed frameworks demonstrate the potential for addressing a broad spectrum of complex problems, from resource allocation in smart grids to dynamic scheduling in manufacturing systems. The integration of cutting-edge CI methods offers a promising future for optimizing performance and solving real-world problems in a wide range of industries.
An Efficient Nano Scale Sequential Circuits with Clock Inherent Capability in QCA For Fast Computation Paradigm
Authors: S. Lekashri  , R. Ramya  , A.N. Duraivel  , K. Kalpana
Published: January 2025

Quantum-Dot Cellular Automata is a cutting-edge nanotechnology emerging in the globe, has supplanted the conventional CMOS technologies. Because it doesn't use electric current, this method uses less power because of the Coulomb interaction. This sequential circuit design concept is the most challenging approach in the field of QCA technology. In this proposed study, to design a novel D type flip-flop with pulse generator is included. This plan involves the design of n-bit counter using frequency divider approach. In this approach a novel D flip-flop worked with pulse generator. The QCA Designer, which compares the simulation findings with the suggested constructed circuits, is used to implement the suggested technique. The QCA Designer E tool is used to verify the power usage, which forms the basis of the performance analysis. The suggested plan provides the lowest power and improved performance factors based on the examination of the current approaches.
"I Won't Buy This Product Again": The Boycott Determinants on Loyalty Using Animosity Model Approach
Authors: Dzikhrullah Harits Dijani , Vania Amelindha
Published: January 2025

Objectives: The paper investigates the correlation between McDonald's consumption and protest actions in Indonesia, with a particular focus on customer loyalty, customer ethnocentrism, consumer efficacy, and war animosity.Methodology: This research used the animosity model technique and a sample of around 200 respondents, determined by purposive sampling methods. Data were analyzed using the PLS-SEM method with the help of SmartPLS 3.0 software.Finding: The research demonstrates that customer ethnocentrism, consumer efficacy, and war animosity have a positive impact on boycotts, however, boycotts have an important negative effect on loyalty.Conclusion: The research analyzes the viewpoints of McDonald's customers about the CEO's position on governmental interference in a foreign country, with a particular focus on the issue surrounding the company's product. Certain customers express their dissatisfaction, while others engage in a boycott of McDonald's to compel changes in company policies. The study is conducted in Aceh, a place renowned for its strong religious convictions, with a specific emphasis on the local responses to McDonald's conduct.
Reflections on lifelong learning in english as a foreign language learning: a case study in a colombian university corporation
Authors: Bendeck Soto Juan , Cardona Jiménez Jairo León
Published: January 2025

To learn a foreign language such as English could be considered as a big effort in different types of universities, which demands students to see it as a lifelong learning education. Nevertheless, learners do not always see it this way and don’t seem to be ready for such an approach. Therefore, it is relevant to identify what orientations manage toward learning English as a Foreign Language (EFL) and determine their understanding towards the language development and acquisition through the concept of Lifelong Learning (LLL). The following study was conducted considering an instrument designed by the social worker Caroline Proulx (lifelong learning questionnaire), with the purpose of knowing the level of lifelong learning students manage in a private university, in its different modalities regarding the English language learning; the instrument was adjusted with components focused on EFL (English as a Foreign Language). Data was collected using this research tool via online and evaluation ranges were determined to determine how much students at a private university in Medellin enjoy learning the language, considering items such as gender, age, and average scores of the different sections of the instrument. Gender was found to make a significant difference in the students’ LLL orientations, age was seen as a relevant finding in a specific population of learners, and the sections of the questionnaire displayed the aspects to improve in the institution for learning EFL in virtual and physical modalities. Suggestions are given for improving and promoting the learning of the English language through continuing education in the institution, motivating students to not desist from learning the language for their respective careers (that means, develop a lifelong learning attitude), and giving learning techniques to students for learning the language better.
La reconfiguración educativa de YouTube: un análisis crítico del caso Mi Aula
Authors: Dughera Lucila , Dolcemascolo Agostina
Published: January 2025

El avance de la industria educativa global y la plataformización de la educación, nos convocan a analizar el creciente proceso de reconfiguración y legitimación de la plataforma de videos YouTube como espacio educativo, sobre todo en la educación formal. Para esto abordamos Mi Aula, canal producto de la alianza entre la plataforma y UNESCO. A partir de dicho caso, nos proponemos producir evidencia empírica que contribuya a precisar cuáles son las consecuencias del avance de este tipo de plataformas en la educación. La metodología, de carácter cualitativo, se funda en el estudio del caso Mi Aula, junto con la revisión literaria, el análisis de fuentes secundarias y la observación no participante del canal. Los hallazgos más destacados señalan que, ante el avance de la plataformización, resulta necesario revisar cuestiones estructurales que atañen, por un lado, al acceso a los contenidos del canal por parte de los actores educativos, y, por otro, al funcionamiento y modelo de negocios de la plataforma.
Current Improvements to the Acute Respiratory Distress Syndrome Definition
Authors: Eroglu Ahmet
Published: January 2025

ARDS was first described with cases in 1967 and it became a broad agenda with 4 basic criteria determined at the AmericanEuropean Consensus conference in 1994, and then it reached its peak with the Berlin Definition in 2012, with effects that
continue to this day. However, later on, the definition was moved to a better level with objections to the Berlin definition and
remarkable new recommendations. However, remarkable new recommendations after Berlin brought its definition to a better
level. An attempt was made to better define it with many biomarkers in blood and broncho alveolar lavage. It was recommended
to define ARDS Specific Marker (ASM) and ARDS Severity Score (ASS), which could help determine its severity and mortality.
Although there is no definitive treatment, many recommendations have been made for its management. Low tidal volume
ventilation, prone position and High-Flow Nasal Oxygen (HFNO) application to non-intube patients have remained important in
management over a long period of time. PEEP titration, negative fluid balance, non-invasive ventilation, use of muscle relaxants
and Extracorporeal Membrane Oxygenation (ECMO) applications were also discussed on a patient-by-patient basis. Despite
improvements in definition and management, the mortality rate of it still remains high. There continues to be a need for new
studies and methods regarding the definition and management of ARDS.