bluuebunny/crossref_metadata_2025 huggingface dataset:
Key Genes Are Associated with the Prognosis of Glioma, and Melittin Can Regulate the Expression of These Genes in Glioma U87 Cells
Authors: Li Ran , Tao Ting , Ren Qiuyun , Xie Sujun , Gao Xiaofen , Wu Jie , Chen Diling , Xu Changqiong
Published: December 2022

Glioma is the most common primary tumor of the central nervous system. Currently, there is no effective treatment for glioma. Melittin (MT) is the main component of bee venom, which was found to have therapeutic effects on a variety of tumors. In this study, we explored the relationship between key genes regulated by MT and the prognosis of glioma. In cultured glioma U87 and U251 cells, MT inhibited cell proliferation and induces cell apoptosis in a time‐ and concentration‐dependent manner. RNA‐seq revealed that MT upregulated 11 genes and downregulated 37 genes. These genes are mainly enriched in cell membrane signaling pathways, such as surface membrane, membrane‐enclosed organelles, integral component of membrane, PPAR signaling pathway, and voltage‐gated potassium channel. PPI network analysis and literature analysis of 48 genes were performed, and 8 key genes were identified, and these key genes were closely associated with clinical prognosis. Overexpression of PCDH18, PPL, DEPP1, VASN, KCNE4, MYBPH, and C5AR2 genes or low expression of MARCH4 gene in glioma patients was associated with poor survival. qPCR confirmed that MT can regulate the expression of these genes in glioma U87 cells. This study indicated that MT significantly inhibited the growth and regulated the expression of PCDH18, C5AR2, VASN, DEPP1, MYBPH, KCNE4, PPL, and MARCH4 genes in glioma U87 cells in vitro. These genes are closely related to the prognosis of patients with glioma and can be used as independent prognostic factors in patients with glioma. MT is a potential drug for the treatment of glioma.
The Effect of Alcohol Consumption in Unresectable Hepatocellular Carcinoma with Transarterial Chemoembolization
Authors: Sun Bo , Zhang Lijie , Xiang Dongqiao , Li Qing , Ren Yanqiao , Cao Yanyan , Sun Tao , Zhang Weihua , Wu Linxia , Zhu Licheng , Chen Lei , Zhao Huangxuan , Zheng Chuansheng
Published: December 2022

Background. Alcohol consumption can increase the risk of developing hepatocellular carcinoma (HCC). However, whether continuous alcohol consumption can influence outcomes in patients with HCC who undergo transarterial chemoembolization (TACE) remains unclear. This study aimed to explore the effect of alcohol consumption in patients with unresectable HCC who underwent TACE. Methods. The data used in the study were obtained from two centers and were retrospectively reviewed between January, 2014, and December, 2021. 254 patients with TACE were included in this study. Among them, 101 patients were continuous alcohol consumers and 153 patients had alcohol abstinence. Propensity score matching (PSM) and competing risk analysis were used to reduce the selection bias. Results. The median overall survival (mOS) and median progression-free survival (mPFS) in the alcohol consumers’ group were longer than those in the alcohol abstinence group, before and after PSM. Multivariate regression analysis showed that alcohol consumption increased all-cause mortality risk (HR: 1.486, 95% CI: 1.074–2.055;

P
=
0.016

) and tumor progression risk (HR: 1.434, 95% CI: 1.091–1.886;

P
=
0.01

) more than that with alcohol abstinence. In the competing risk analysis, after excluding deaths caused by other reasons, alcohol consumption increased cancer-specific mortality risk more than alcohol abstinence did before and after PSM. Adverse event analysis showed that alcohol consumption increased the risk of all grades of nausea and vomiting and grade III or IV nausea more than alcohol abstinence did after patients underwent TACE. Conclusion. Alcohol consumption may lead to a poor prognosis and increase adverse events in patients receiving TACE compared to those with alcohol abstinence.
Australia in Oak, Copper, and Quartz
Authors: Hickey Robert
Published: December 2022

This article describes a map I made based on a trip to Western Australia I took with my wife in 2014. The map is sculptural, constructed using a combination of wood, metal, and semi-precious gemstones. For the base of the map, I used a 44.5 × 40.5 in (113 × 103 cm) piece of quarter-sawn white oak veneer plywood. Guided by a 1-inch (2.54 cm) grid system, I drilled 773 holes of four different diameters to show the land area and general shape of the continent. I chose two different gauges of copper wire to represent driving and train routes. Amethyst stones represent alkaline saline lakes that Holly—an extremophile microbiologist—sampled for resident microbiota. For the one acidic saline lake she sampled (pH 3.5), I used rose quartz instead of amethyst. I highlighted the stromatolites we observed at Shark Bay (Western Australia) with a green diopside mineral. Finally, anywhere we stayed of note is represented with one (or more) red map pins. The final product is 44.5 × 40.5 in (113 × 103 cm) at a scale of 1:4,118,400 (1 in = 65 mi; 1 cm = 41.2 km).
The effect of three different sets method used in resistance training on hypertrophy and maximal strength changes
Authors: Demirtaş Barbaros , Çetin Onat , Çakır Ergün , Beyleroğlu Malik
Published: December 2022

Background and Study Aim. To compare the effects of three different sets method, which is frequently used in resistance training, on strength and hypertrophy values.
Materials and Methods. Thirty-three young male athletes with similar daily activities and nutrient intakes at the Fitlife fitness center in Sakarya were included in the study. Participants were randomly divided into three different groups as Modified German Volume Training (MGVT) (n=11, 21.5 ± 2.4 years), Super Set (SS) (n=11, 22.4 ± 2.9) and Giant Set (GS) (n=11, 23.0 ± 4.3 years). The study was started with a total of thirty-three people, but two participants in the Giant set group were excluded from the measurements because they left the study due to personal reasons. Strength, muscle thickness and cross-sectional area (CSA) measurements were made in the upper extremity muscles before and after the six-week training period.   
Results. After six weeks of training, significant increases were observed in the cross-sectional area and thickness (p<0.05) of pectoralis major, deltoid, and latissimus dorsi muscle groups in all three groups, and in the strength parameter (p<0.05) in bench press, barbell row and shoulder press exercises. There was no difference in strength, muscle cross-sectional area and thickness parameters between the groups (p>0,05).  
Conclusions. Modified German Volume Training (MGVT), Super Set (SS) and Giant Set (GS) methods reveal that there is no difference between the set methods in the 1 Repetition Maximum (1RM) strength and hypertrophy development of young male individuals who do not have a history of resistance exercise but have completed the adaptation period, and that there is an improvement in all set methods.
When every ideal is $\phi$-P-flat
Authors: KIM Hwankoo , MAHDOU Najib , OUBOUHOU El Houssaine
Published: December 2022

Let $R$ be a commutative ring with nonzero identity. An $R$-module $M$ is called $\phi$-P-flat if $x \in \Ann(s)M$ for every non-nilpotent element $s \in R$ and $x\in M$ such that $sx=0$. In this paper, we introduce and study the class of $\phi$-PF-rings, i.e., rings in which all ideals are $\phi$-P-flat. Among other results, the transfer of the $\phi$-PF-ring to the amalgamation is investigated. Several examples which delineate the concepts and results are provided.
BAŞLANGIÇ FLÜT EĞİTİMİNDE KULLANILAN GIUSEPPE GARIBOLDI’NİN “DIE ERNSTEN ÜBUNGEN FÜR FLÖTE” İSİMLİ ETÜT KİTABININ ANALİZİ
Authors: SOYCAN Merve
Published: December 2022

Çalışmada Giuseppe Gariboldi’ye ait etüt kitabının teknik açıdan incelenmesi amaçlanmıştır. Bu amaç doğrultusunda kitapta bulunan 58 etüt, içerdiği tonalite, ölçü sayısı, oktav aralığı, tartım, artikülasyon, süsleme, modülasyon, aralık, arpej ve dizi bakımından incelenmiştir. Verilerin değerlendirilmesinde içerik analiz tekniklerinden kategorisel analiz kullanılmıştır. Araştırmada belirlenen kategoriler frekans analizine tabi tutularak tablolaştırılmış ve yorumlanmıştır. İncelenen etüt kitabında, etütlerin çoğunluğunun do majör ve sol majör çalışmalardan oluştuğu, etütlerde basit ve bileşik ölçü sayısına, tartım ve artikülasyon çeşitliliğine, modülasyonlara, arpej, dizi, aralık, uzun ses çalışmalarına yer verildiği, etütlerin içerdiği en ince ve en kalın sesler incelendiğinde, 3 oktav ses aralığı içerisinde flütün hemen her notasına yönelik çalışma yaptırdığı tespit edilmiştir. İncelenen etüt kitabının başlangıç flüt eğitimine uygun olduğu sonucuna ulaşılmıştır.
Antioxidant and Antimicrobial Capacity of Quinic Acid
Authors: ERCAN Leyla , DOĞRU Mehmet
Published: December 2022

Recently, agents with natural antioxidant and antimicrobial properties have been popularly studied. For this purpose, phenolic compounds, terpenes, and organic acids are examined in their antioxidant and antimicrobial properties. Of these, organic acids are increasingly being used in pharmacology, medicine, food, and industry. Quinic acid is a natural organic compound found in many edible fruits and plants. In this study, the antioxidant effect of quinic acid, which has the structure of cyclohexane carboxylic acid, was determined in vitro using seven different methods (DPPH, ABTS, CUPRAC, DMPD, FRAP, Fe3+ reduction, and Total antioxidant method). In addition, its antimicrobial effect on fungi (C. albicans), gram-positive bacteria (S. aureus, S. pyogenes), and gram-negative bacteria (E. coli, K. pneumoniae, and P. aeruginosa) were determined by the disk diffusion method. As a result, it was found that quinic acid has broad-spectrum antimicrobial properties, but its antioxidant properties are too low to be highlighted. While its antimicrobial activity was quite good, especially on K. pneumoniae E. coli, S. aureus, S. Pyogenes, and P. aeruginosa, it did not show any effect on C. albicans. Although the antioxidant property of quinic acid is low, it showed more antioxidant properties in the DMPD method, which is one of these methods, because it dissolves very well in water.
Osseointegration after local cryotherapy
Authors: Shakurov Alexey V. , Skryabin Andrey S. , Lukina Yulia S.
Published: December 2022

The purpose of this study is to analyze the prospects for the use of local cryotherapy in bone remodeling. Intense cooling causes a response. To evaluate the effectiveness of cryostimulation of a bone defect in the in vivo model of Wistar rats, through defects 2 mm in diameter were formed. The animals were subjected to 1 and 2 cryotherapy per week. The average local temperature of the skin surface decreased from 28 to 14 C. The decrease in temperature inside the biological tissue near the bone defect was 5.3C. Microcomputer tomography and histological analysis showed that cryotherapy 2 times per week is an effective method. The results showed the promise of using low temperatures in the complex treatment of injuries and bone diseases. This information will be useful for understanding the correlation of the effect and impact of cryostimulation, as well as for the development of treatment protocols, the study allows us to take a step towards the possibility of bone healing using cryostimulation in practice.
Local low-temperature exposure: destruction, preservation, therapy
Authors: Pushkarev Aleksandr V. , Saakyan Natalia Y.
Published: December 2022

Local low-temperature impact on biological tissues, depending on the temperature reached, can lead to destructive, preserving or therapeutic effects. The article describes the principle of a unified approach for the transition from mass recommendations for the dosing of local low-temperature exposure to personalized. It is proposed to divide the exposure process into three stages: planning, provision and control, analysis of compliance with the planned and received dose. Examples of solving the problems of heat transfer in cryosurgery and cryopreservation are given for a possible improvement of the planning stage. In the framework of the first direction, two cases are considered. The first is to improve the accuracy of prostate cryoablation planning. The second is a comparison of the effectiveness of various materials of cryosurgical applicators: copper, brass and artificial sapphire, which can be used to influence and control the freezing zone by optical methods. Within the framework of the second direction, a case of using local low-temperature exposure to solve the problem of simultaneously preserving the framework of a biological tissue and removing a layer of donor cells, called decellularization, is shown for the purposes of transplantology. The results of the above examples can potentially be used in planning a local low-temperature impact. Based on this approach, it is possible to develop methods and technologies of a new generation with the possibility of accurate dosing.
The State of Loneliness among Migrating Students: The Effect of Psychological Well-Being and Religiosity
Authors: Laksmidara Mahadewi , Nashori Fuad
Published: December 2022

Being separated from their parents causes many  migrating  students to experience loneliness, not to mention their age range is prone to it. Therefore, this study aims to determine the effect of psychological well-being and religiosity on loneliness and isolation in  migrating students using ex post facto quantitative research methods. Respondents to this study were active 213  migrating students in several universities in Yogyakarta Special Religion, Indonesia. Their ages ranged from 18 to 24 years old. The measuring instruments used were UCLA Loneliness version 3 (α 0.942), the Psychological Well-being Scale (α 0.776), and The Centrality of Religiosity Scale (α) 0.876). The data analysis technique used was multiple regression. The results indicated a significant negative effect of psychological well-being on loneliness and no significant negative impact of religiosity on loneliness in  migrating  students. Psychological well-being and religiosity contributed 58.2% to influencing the loneliness variable. The main conclusion this study is psychological well-being makes migrating students experience less loneliness when they are far away from their hometowns.
Occult hernia: role of laparoscopy in detecting the unseen
Authors: Manoharan Vinoth , Joshi Abhijit S.
Published: December 2022

Background: OH (occult hernias) refer to those hernias which are not evident on clinical examination, but which are noted either on surgical exploration or on good quality pre-operative imaging. Identifying them in day-to-day practice is of immense importance in view of unexplained and undiagnosed symptomatology, post-operative recurrences and cost effectiveness. The main objective of this paper is to study the incidence of occult hernias diagnosed intra-operatively during laparoscopic groin hernia surgery.Methods: In this retrospective study, we identified 723 patients who underwent laparoscopic repair of groin hernia in our institute by a single surgeon, from 2008 to 2021. OH were found in 120 patients, all during totally extraperitoneal approach (TEPA) and none during transabdominal pre-peritoneal approach (TAPP). The age range of these 120 patients was 22 to 83 years (mean: 60.7 years with SD: ±12.5 years). The patients were also analysed for sex, type of OH, side of OH and post-operative outcomes.Results: Incidence of OH in our study was 16.59% (120 out of 723 patients). OH were found in both male as well as female patients. These comprised of unilateral and bilateral OH. Patients with unilateral OH heavily outnumbered those with bilateral OH (n=117 vs. 3). There were 3 different types of OH in our study-inguinal, femoral and spigelian. The maximum number of cases were of inguinal OH (n=115). Among inguinal OH, patients with direct OH outnumbered those with indirect OH (n=73 vs. 40).Conclusions: Awareness about OH as an entity is important, as their identification and concurrent repair possibly spares the patient another surgical intervention at a later date.
A comparative study of on-lay and preperitoneal mesh repair in the management of umbilical hernia
Authors: Panguluri Adi Sukumar Nikhil Mehra , Komatreddy Gagandeep Reddy , Venkat Poojitha Reddy Gangam , Teja Katra Sai
Published: December 2022

Background: Umbilical hernias can cause distress to the patients not only because of their complications but also because of the cosmetic angle, therefore this study was undertaken mainly to study the outcomes of preperitoneal mesh repair and on-lay mesh repair in the management of umbilical hernias.Methods: The present study was a prospective, observational and comparative study undertaken in the department of general surgery, who had been operated in Kamineni hospital LB Nagar, Hyderabad, Telangana, during a study period from November-2020 to September-2021.Results: Of 30 patients who underwent on-lay mesh repair, the mean hospital stay was 3.83±1.8 days; wound infection, seroma, hematoma, flap necrosis was seen in 1, 4, 2, 1 respectively and with no recurrence in 6 months follow-up. Of 30 patients who underwent pre-peritoneal mesh repair, the mean hospital stay was 2.13±0.63 days; Wound infection, seroma, hematoma, flap necrosis was seen in 0, 2, 1, 0 respectively and with no recurrence in 6 months follow-up.Conclusions: On-lay mesh repair can be replaced with preperitoneal mesh repair. Overall mesh related complications, including wound infection, seroma, hematoma, flap necrosis is quite rare. Less Hospital stay and low recurrence rate was observed in preperitoneal method. As wound complication increases risk of recurrence, procedures that do not result in formation of de-vascularizing flaps may be recommended.
The Effect of a Training Package on Self-Efficacy and Mental Health of Female High School Students regarding the Healthy Human Theory
Authors: Asadi Anita , Aghaei Asghar
Published: December 2022

Introduction: The aim of this study is to investigate the effect of educational package of healthy human theory on self-efficacy and mental health of female high school students in Fooladshahr.
Methods: The research method was quasi-experimental and included a pretest, posttest and a one-month follow-up. The statistical population included all the female high school students (1,200 students) in Fooladshahr in the academic year 2020-2021. Convenience sampling method was used ,and a secondary school in Fooladshahr was selected. Then, mental health screening and self-efficacy questionnaires were distributed among the students. In the second stage, 30 students were selected from those who had lower mental health and self-efficacy and were willing to participate in the study. They were randomly assigned to  experimental (n = 15) and control (n = 15) groups. The experimental group received thirteen sessions of a revised version of training based on the healthy human theory (Aghaei, Asadi, 2021). The control group remained on the waiting list. Data collection tools in the pretest, posttest and follow-up stages included the Morris Children and Adolescents Self-Efficacy Questionnaire (2001) and the Keys Mental Health Scale (2002). In order analyze data, the analysis of variance with repeated measures was used.
Results:  The results showed that the training package regarding the healthy human theory had a significant effect on improving self-efficacy and mental health of students in the posttest stage (p <0.001). The effect continued to the follow-up stage (p <0.001).
Conclusion: According to the findings of this study, it can be said that the training package regarding the healthy human theory has been a suitable method for improving self-efficacy and mental health of female students from senior high school.
«Authority» as a factor in evaluating the activity of Odesa city mayors within the period from the second half of the 19th century to the beginning of the 20th century by contemporaries
Authors: Herasymenko Viktoriia
Published: December 2022

The article examines the importance of one of the factors in evaluating the activity of city mayors as authority (position, status, etc.). In the second half of the 19th – at the beginning of the 20th century. the self-government of Odesa was headed by Semen Vorontsov, Mykola Novoselskyi, Grigory Marazli (Grigorios Maraslis), Valerian Ligin, Petro Kryzhanovskyi and Pavlo Zelenyi. On the basis of the collected sources (notes from the press and memories of contemporaries) and due to the activity and position of the city mayor the establishment of the authority of the above-mentioned personalities was analyzed.
The authority is based on professionalism, knowledge, moral principles, social status, experience or myths. Due to authority, human can exercise control over people's actions. There are also different authorities of a person's quality (scientific, business, moral, religious, etc.) and his status (respect for the position). The effectiveness of government largely depends on its authority.
The main sources for determining the assessment of the authority factor of the Odesa city mayors of 1863-1905 are the press (the newspapers «Odesa Herald», «Odesa News», «Odesa Leaf», etc.), diaries and memories of contemporaries (E. Andreevskii, K. Skalkovskyi, M. Lents, etc.).
As a result of studying a number of personalities, it became clear that the group of Odesa mayors was diverse. Taking the position of mayor during the elected term, S. Vorontsov, M. Novoselskyi, G. Marazli, V. Ligin, P. Kryzhanovskyi and P. Zelenyі acquired status authority (respect for the position of the head of the city self-government). However, not all of the above-mentioned persons could use it qualitatively.
Sosialisasi Kebijakan Kampus Merdeka Program Praktisi Mengajar pada Perguruan Tinggi Penyelenggara Pendidikan Vokasi
Authors: Rahman Abdul , Mawar Mawar , Nurul Bariyah Oneng , Setyaningrum Intan
Published: December 2022

Kementerian Pendidikan, Kebudayaan, Riset, dan Teknologi telah menetapkan kebijakan Kampus Merdeka sebagai prioritas kebijakan. Program Praktisi Mengajar merupakan Kebijakan Merdeka Belajar Edisi ke-20 yang diluncurkan karena faktanya saat ini jumlah praktisi yang ikut berkontribusi mengajar di kampus (baik akademik maupun vokasi) masih kurang. Di sisi lain, tingkat partisipasi perguruan tinggi penyelenggara pendidikan vokasi dalam program Praktisi Mengajar masih sangat sedikit, per tanggal 28 Mei hanya 13 pendaftar. Padahal keberadaan pendidik dari unsur praktisi dunia kerja merupakan hal yang esensial dalam pendidikan vokasi yang sangat erat berkaitan dengan dunia kerja. Oleh karena itu, kegiatan pengabdian ini bertujuan untuk meningkatkan partisipasi perguruan tinggi penyelenggara pendidikan vokasi pada program Praktisi Mengajar. Sementara metode pengabdian masyarakat dilakukan dengan metode sosialisasi. Hasilnya, setelah dilakukan sesi sosialisasi, pendaftar program Praktisi Mengajar dari entitas perguruan tinggi penyelenggara pendidikan vokasi per 6 Juli 2022 meningkat signifikan menjadi 238 pendaftar. Namun, masih terdapat kekurangan, dimana mayoritas kampus vokasi pendaftar program masih didominasi di pulau Jawa dengan persentase 56,1%. The Ministry of Education, Culture, Research, and Technology has set the Merdeka Campus policy as a policy priority. The Teaching Practitioner Program is the 20th Edition of the Free Learning Policy, which was launched because, currently, the number of practitioners who contribute to teaching on campus (both academic and vocational) still needs to be improved. On the other hand, the participation rate of universities providing vocational education in the Teaching Practitioner program still needs to be higher; as of May 28, there were only 13 applicants. The existence of educators from the practitioners of the world of work is essential in vocational education, which is very closely related to the world of work. Therefore, this service activity aims to increase the participation of tertiary institutions providing vocational education in the Teaching Practitioner program. At the same time, the community service method is carried out by the socialization method. As a result, after the socialization session, the registrants for the Teaching Practitioner program from higher education entities providing vocational education as of July 6, 2022, increased significantly to 238 registrants. However, there are still areas for improvement, where most vocational campuses for program applicants are still dominated on the island of Java with a percentage of 56.1%.
Investigation of serum leptin, ghrelin, irisin, insulin levels and their correlations in cattle with subclinical ketosis
Authors: ERGİN EĞRİTAĞ Hale , MERHAN Oğuz , BOZUKLUHAN Kadir , VAROL Kemal , ATCALI Türker
Published: December 2022

In this study, it was aimed to investigate the correlations with leptin, ghrelin, irisin and insulin levels in the blood serum of cattle with subclinical ketosis. For this purpose, 10 healthy and 10 Holstein cattle with subclinical ketosis obtained from farms in Burdur region were used. A diagnosis of subclinical ketosis was made according to the Rothera test performed in milk, by performing a general clinical examination of the animals. Blood samples were taken from vena jugularis into tubes without anticoagulant. Serum leptin, ghrelin, irisin and insulin levels were measured in the obtained sera using commercial ELISA kits. In cows with subclinical ketosis, serum ghrelin, leptin, irisin and insulin values were increased compared to the control group (p
University of Montreal’s Clinician-Investigator Program: A 10-Year Descriptive Evaluation
Authors: Mailhot-Larouche Samuel , Chauvette Vincent , Bergeron David , Larochelle Catherine , Du Pont-Thibodeau Geneviève , Wang Han , Cardinal Héloïse , Bourdeau Isabelle , Auger Nathalie , Bureau Nathalie Bureau, MD, MSc , Prat Alexandre , Jutras-Aswad Didier , Madore François , Emeriaud Guillaume , Bahig Houda , Mayrand Marie-Hélène , Tadros Rafik , Parent Stefan , Richebe Philippe  Richebe, MD, PhD , Merhi Yahye , Nguyen Dang
Published: December 2022

Purpose: Clinician-investigators have an important role in the development and implantation of new therapies and treatment modalities; however, there have been several reports highlighting a pending shortage in the clinician-investigators’ workforce. In Canada, the Royal College has promoted the development of clinician-investigators programs (CIP) to facilitate the training of these individuals. There is currently a paucity of data regarding the outcomes of such programs. This study aims to identify the strengths and areas of improvement of the Montreal University CIP. 
Methods: An internet-based 51-question survey was distributed to all the alumni from the University of Montreal CIP. Participation was voluntary and no incentives were provided. The response rate was 64%. 
Results: Among respondents, 50% (n=16) had completed their clinical residency and all CIP requirements. The majority of these individuals (63%) had become independent investigators and had secured provincial and national funding. Satisfaction of the respondents was high regarding the overall program (85%), the research skills developed during the CIP (84%) and the financial support obtained during the program (72%). The satisfaction rate regarding career planning was lower (63%). 
Conclusion: This survey demonstrates that, while indicators are favorable, some areas still require improvement. Several steps to improve the CIP have been identified; notably, the transition from the CIP to early independent career has been identified as critical in the development of clinician-investigators and steps have been taken to improve this progression
TREATMENT OF COMBAT SURGICAL TRAUMA OF THE LIMBS IN THE CONDITIONS OF MODERN WAR
Authors: Trutyak Ihor , Los Dmytro , Medzyn Valentyn , Trunkvalter Vasyl , Zukovsky Volodymyr
Published: December 2022

Among the total number of wounded who entered the Military Medical Clinical Center of the Western Region from February to September 2022, combat injury to the limbs was in 63.3%. Bullet wounds caused combat injury to the limbs in 10.4%, shrapnel and mine-explosive – in 68.1%, explosive injury – in 21.5%. At the second role of medical care, emergency surgical interventions were performed on the wounded, immobilization of bone fractures with an external fixation and anti-shock therapy. At the third and fourth roles – the treatment of the wounded consisted in the use of a multidisciplinary approach with the involvement of doctors of various specialties, first of all, general surgeons, traumatologists, vascular, plastic surgeons and anesthesiologists. The most frequent surgical intervention was repeatened and secondary debridment of gunshot wounds, which was required by 93% of the wounded. The main pathogens that vegetated in wounds were Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter aerogenes, Proteus vulgaris, Enterococcus faecalis with high levels of microbial contamination – 104-108/g in tissues., Various types of plastics were used to close soft tissue defects, according to the rule of the reconstruction ladder. After healing a soft tissue wound to determine the timing of replacing the method of fixing fractures with internal osteosynthesis, were analyzed clinical and laboratory parameters and assessed the risks of complications. The main causes of amputations of the limbs were common defects in soft tissue and bones, which were not subject to reconstruction with no prognosis for bone fusion and progression of the infectious-necrotic process.
Given According to Knowledge, Motivation and Behavioral Skills (IMB Model) The Effect of Diabetes Education on Self-Care
Authors: İNKAYA Bahar , YILMAZER Tuba , TÜZER Hilal , ERBİL Elif Yeter
Published: December 2022

Aim: It has been determined that the education given according to the information, motivation, and behaviour model is effective in AIDS, chronic diseases, glucose control in diabetes, and self-care behaviours such as diet and exercise. The aim of this study, which is planned from this point of view, is to evaluate the effect of education given according to the information, motivation, and behaviour model on diabetic self-care management. Material and Methods: This study was conducted as an experimental study with a nonrandomized control group that included 90 diabetes mellitus individuals, with 45 in the intervention group and 45 in the control group. The control group were given formal diabetes mellitus education. In contrast, the intervention group received an education based on the information, motivation, and behaviour model and diabetes mellitus cases were followed for six months. Data were collected with a questionnaire on the essential characteristics of the patients, an evaluation form on the level of knowledge about diabetes, an evaluation form on their motivation about diabetes, and a diabetes self-care activities questionnaire. An Independent Sample-t test was used to analyze the data, and Paired Sample-test statistics were used to compare two dependent groups. Mann-Whitney U test was used to compare the measurement values of two independent groups that did not have a normal distribution. Wilcoxon test statistics were used to compare two dependent groups. Results: At the end of the study, it was determined that while HbA1c in the intervention group decreased for 6 months, knowledge scores, motivation levels and self-care skill scores increased (t=7.067, p
Review of We Do This ‘Til We Free Us: Abolitionist Organizing and Transforming Justice by Mariame Kaba (Haymarket Books)
Authors: Kelly Esteban
Published: December 2022

What if social transformation and liberation isn't about waiting for someone else to come along and save us? What if ordinary people have the power to collectively free ourselves? In this timely collection of essays and interviews, Mariame Kaba reflects on the deep work of abolition and transformative political struggle. With chapters on seeking justice beyond the punishment system, transforming how we deal with harm and accountability, and finding hope in collective struggle for abolition, Kaba's work is deeply rooted in the relentless belief that we can fundamentally change the world. As Kaba writes, 'Nothing that we do that is worthwhile is done alone' (172).
Antibacterial behavior and bacterial resistance analysis of P. aeruginosa in contact with copper nanoparticles
Authors:   Centro de Investigación y Desarrollo Tecnológico en Electroquímica CIDETEQ. S.C., Parque Tecnológico Querétaro s/s Sanfandila, Pedro Escobedo, Querétaro. C. P. 76703, Mexico, Quintero-Garrido Karen Guadalupe , Ramírez-Montiel Fátima Berenice , Chávez-Castillo Marilú , Reyes-Vidal Yolanda , Bacame-Valenzuela Francisco Javier , Padilla-Vaca Felipe , Palma-Tirado Lourdes , Estevez Miriam ,   Universidad Tecnológica Emiliano Zapata del Estado de Morelos. Av. Universidad Tecnológica No. 1, Col. Palo Escrito, Emiliano Zapata, Morelos. C. P. 62760, Mexico,   Departamento de Biología, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria alta s/n, Guanajuato, Guanajuato. C. P. 36050, Mexico,   Instituto de Neurobiología, Universidad Nacional Autónoma de Mexico. Boulevard Juriquilla No. 3001, Juriquilla, Querétaro. C. P. 76230, Mexico,   Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de Mexico, Boulevard Juriquilla 3001, Querétaro, Qro., 76230, Mexico, España- Sánchez Beatriz Liliana
Published: December 2022

The present study describes the antibacterial behavior and the bacterial resistance analysis of extremophile Pseudomonas aeruginosa in contact with copper nanoparticles (CuNPs). For this purpose, green synthesis of CuNPs was performed by combined ultrasound-assisted and chemical reduction methods, obtaining semispherical CuNPs ranging from ca. 4-9 nm. Antibacterial activity (AA) of biosynthesized CuNPs demonstrates an antibacterial inhibition of 85 % (LD85) at 400 μg/mL and a minimum bactericidal concentration (MBC) of 800 μg/mL after 3 h of contact. Bacterial adaptation in contact with CuNPs was observed through the consecutive exposition of microorganisms, presenting a significant increase of LD85 values from 400 μg/mL to 6400 μg/mL after 11 expositions. This behavior demonstrates the bacterial growth adaptation with high-dose of CuNPs. The bacterial resistance mechanism was determined through the overproduction of pyocyanin, associated with oxidative stress events, the genomic polymorphism of resistant bacteria obtained by PCR-RAPDs, and the morphological interaction between P. aeruginosa and CuNPs evidenced by transmission electron microscopy (TEM) micrographs. Our results suggest that under controlled CuNPs exposition, extremophile P. aeruginosa can generate bacterial resistance mechanisms, an important issue for the effective design of antimicrobial nanomaterials.
Extraction and characterization of a biosurfactant synthesized by Acinotebacter baumannii
Authors:   Laboratorio de Biotecnología, Universidad Juárez Autónoma de Tabasco. Km. 1 Carretera Cunduacán-Jalpa, Colonia La Esmeralda, Cunduacán, C.P. 86690, Tabasco, Mexico, Torres-Custodio Rubicel , Hernández-Rivera Miguel Ángel , López-Lázaro José de los Santos , Córdova-Bautista Yolanda , Álvarez-Ramírez Juan Gabriel , Sifuentes-Gallardo Pio , Ojeda-Morales Marcia Eugenia
Published: December 2022

Biosurfactants are metabolites produced by microorganisms during their growth and reproduction. They are amphiphilic molecules capable of modifying surface and interfacial tension. A petrophilic, nitrogen-fixing, phosphorus-solubilizing, and biosurfactant-producing bacterial strain was isolated and characterized. The isolated strain was cultivated in Kim medium with a C:N ratio of 2:1, from which its growth kinetics was determined. Samples of the culture broth were taken at different times and the collapsed drop, oil dispersion and emulsification index tests were performed. Maximum culture growth occurred at 72 h. The biosurfactant was extracted from the crude cell-free broth using a mixture of solvents and a yield of 2.21 g/L was obtained. Thin-layer chromatography and FT-IR analyzes revealed the presence of a lipopeptide biosurfactant. Tensiometry tests showed that the biosurfactant was able to lower the surface tension of water from 72 mN/m to 40 mN/m and the critical micelle concentration was 0.058 (w/w). Probit analysis for toxicity determination showed that there was no weight loss in Eisenia foetida specimens in a range between 10000 and 50000 ppm.
EL & EL:
Authors: CLEMENTE BRUNO DIEGO DE OLIVEIRA , OLIVEIRA ELLEN DOS SANTOS , COSTA FABRÍCIO DA , BARBOSA GABRIELLE DOS SANTOS , JESUS GLÁUCIA GALVÃO DE SOUZA , CARDOSO HÉLIA DA SILVA ALVES , SANTOS JÉSSICA CAROLINE PESSOA DOS , OLIVEIRA JOÃO PAULO DE , SANTOS JOSÉ VÂNDESSON DOS , VASCONCELLOS LAYLA DE OLIVEIRA , MAGALHÃES LIARA OLIVEIRA , SANTOS MARIA FRANCISCA OLIVEIRA , MECIAS NATHALIA MARIA RODRIGUES
Published: December 2022

Este livro reúne 11 capítulos de pesquisadores da área de Letras preocupados com questões pertinentes à linguagem, seja no seu uso prático em vários contextos sociais, ou questões relativas ao ensino-aprendizagem, tanto na área de Linguística e de Literatura. Pretende com ele, contribuir com os estudos linguísticos e literários contemporâneos.
Research of hen eggs shell processing with eggshell membrane separation
Authors:   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI RAS (ARSRIPPI), Moscow region, Russia, Maximov Alexander , Romanenko Yuri ,   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI RAS (ARSRIPPI), Moscow region, Russia, Mikhailenko Ivan ,   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI RAS (ARSRIPPI), Moscow region, Russia, Derina Daria ,   “All-Russian Scientific Research Institute of Poultry Processing Industry” — the branch of FSC ARRTPI RAS (ARSRIPPI), Moscow region, Russia
Published: December 2022

The results have been given in the paper on analytical and experimental researches of hen eggs shell further processing processes.
Alterações Climáticas e Argumentos Morais no Twitter: Um Estudo Comparativo entre Brasil e Portugal
Authors: Costa Pedro Rodrigues , Capoano Edson , Balbé Alice
Published: December 2022

O tema das alterações climáticas tende a gerar um conjunto de dilemas e conflitos de interesse que importa ter em consideração. Este estudo tem como objetivo analisar os tweets em língua portuguesa sobre o tema das alterações climáticas, procurando perceber como se posicionam os utilizadores brasileiros e portugueses e as formas de engajamento no Twitter com base nos fundamentos morais. Analisamos as publicações na rede social entre 01 de outubro de 2021 e 01 de abril de 2022, a partir da recolha automática de tweets com base nas palavras-chave e.g. “alterações climáticas”, “mudanças climáticas e “ambiente”, nos tweets a partir do Brasil e de Portugal, num total de 21.327 publicações. Os fundamentos invocados nos tweets provenientes de Portugal geram engajamento com uma visão eurocêntrica do tema e os fundamentos invocados nos tweets provenientes do Brasil geram um tipo de engajamento dualista e baseado em argumentação de ação política nacional.
Comparative study of the metallic contamination assessment of a Paracentrotus lividus (lmck, 1816) macrobenthic community in Algerian west coast
Authors:   Laboratoire Réseau de Surveillance Environnementale, Département de Biologie Faculté des Sciences de la Nature et de la Vie, Université Oran1 Ahmed Ben Bella., Boukhelf K. , Dermeche S. ,   Laboratoire Réseau de Surveillance Environnementale, Département de Biologie Faculté des Sciences de la Nature et de la Vie, Université Oran1 Ahmed Ben Bella., Chahrour F. ,   Laboratoire Réseau de Surveillance Environnementale, Département de Biologie Faculté des Sciences de la Nature et de la Vie, Université Oran1 Ahmed Ben Bella., Bouderbela M. ,   Laboratoire Réseau de Surveillance Environnementale, Département de Biologie Faculté des Sciences de la Nature et de la Vie, Université Oran1 Ahmed Ben Bella.
Published: December 2022

This study assesses the characteristics of the metallic trace elements (Fe, Cd, Cu, Pb and Zn) in the Paracentrotus lividus gonads. The physiological indices evolution (RIm and GIm) was adopted in order to determine the laying period of this echinoid; and to support the hypothesis that this species may be considered as an excellent bioindicator in the marine environment. For this purpose, two edible sea urchin populations with a diameter between 41 and 71 mm were sampled. This samples were taken from two different sites, Salamandre area (presence of rocky seabed rich of photophilic algae, with less biodiversity), and Sidi Lakhdarin area (presence photophilic algae and Posidonia oceanica, more biodiversity). Each sample was evaluated by the coupled plasma mass spectrometry (ICP-MS) method. The results obtained show that there is a significant variation (p<0.005) of physiological indices (RIm and GIm) over time. Besides, an important spawning increase is observed during spring and autumn. The results revealed that gonads metallic contaminations were present in all samples, with very heterogeneous concentrations. Also, it demonstrates that the metallic contamination existed in all seasons, with a clear demarcation of zinc and iron. The zinc quantity is 2.159 mg/l in Sidi Lakhdar and 1.413 mg/l in Salamandre; and the iron quantity is 2.088 mg/l in Sidi Lakhdar and 1.888 mg/l in Salamandre. Unlike zinc and iron, copper and cadmium have small amounts in the two sites. In the autumn, the cadmium quantity is 0.005 mg/l in the two sites; and the copper quantity is 0.068 mg/l in Sidi Lakhdar and 0.065 mg/l in Salamandre. Consequently, this marine species accumulates large quantities of these toxic metals according to the bioavailability of the pollutant in the surrounding environment.
Kemampuan Berfikir Kreatif Siswa dalam Memecahkan Masalah Matematika Konteks Jembatan Gantung Lahat
Authors: Arrasikh M. Arrasikh Hidayatullah , Zulkardi  , Ely Susanti
Published: December 2022

This study aims to determine the level of creative thinking of MTs Negeri 1 Muara Enim stnudents in solving mathematical problems in the context of suspension bridges. Taking the subject using purposive sampling technique, the subjects of this study were 3 students with high mathematical abilities. Test questions to see creative thinking skills and interview clues are used as research instruments. Data reduction, data presentation, and drawing conclusions are outlined guidelines in analyzing data in this study. The results showed that the three subjects in this study had been able to demonstrate and present their creative thinking abilities with diverse levels of creative thinking. Based on the results of the answers to the 2 essay questions given, MSE subjects were able to meet the existence of fluency and novelty indicators which showed that they were at the level of creative thinking ability 3 (creative) while CR and RA subjects were only able to meet the novelty indicators that were at the level of creative thinking ability level 2 (quite creative).
Keyword: Creative thinking, mathematical problems, bridge contexts
A Book Review on Environmental Wisdom for Planet Earth: The Islamic Heritage (Revised Second Edition) by Osman Bakar. Malaysia: Centre for Civilisational Dialogue University of Malaya and Islamic Book Trust. 2022
Authors: Masri Mohd Shazani
Published: December 2022

This book is an introduction to Islam’s legacy of ecological and environmental wisdom prescribed in the Qur’an and in the history of Islamic science and technology. The author attempted to expound the title in question two-pronged: by addressing the spiritual dimension of the environmental wisdom and its scientific-economic counterpart. His main argument centres on highlighting a spiritual vision of nature – in this case, Islamic – that should be embodied and accounted within discussions about ecology and environment based on dialogue. The book is an ideological expansion of Seyyed Hossein Nasr’s seminal work, Man and Nature: The Spiritual Crisis in Modern Man (2007). Specifically, the author emphasizes that the Earth is human beings’ only planetary home and highlights the Quranic take on the proposition. In this revised second addition, it updates the importance of intensifying interfaith dialogues particularly with regards to addressing contemporary environmental issues (i.e climate change) by reflecting on Muslim-Catholic dialogue by referring to the Pope’s Laudato Si in His Holiness’ regards to Earth as Our Common Home in particular. Theoretically, this book is yet another addition to the dialogic approach to inter-civilizational issues to address both practical and spiritual upheavals emanating from such inter-religious discourse about the current state of humanity and its relationship with the environment.
МОЖЛИВОСТІ УТИЛІЗАЦІЇ ЗОЛО-ШЛАКОВИХ СУМІШЕЙ В ДОРОЖНЬОМУ БУДІВНИЦТВІ
Authors:   National Transport University, Баран Сергій , Куцман Олександр ,   National Transport University, Мудрак Клавдія ,   National Transport University
Published: December 2022

The article considers the issue of utilization of thermal power plant waste by using it as man-made soil or granulometric additive to improve the properties of local soil during the construction of road foundations and by replacing the mineral part of bituminous-mineral mixtures with thermal power plant waste, which can in many cases successfully replace deficient asphalt concrete mixture The results of determining the physical and mechanical characteristics of materials using ash-slag mixtures are given. The obtained results indicate the feasibility of using ash-slag mixtures as man-made soil or granulometric additives to improve local soil properties, as well as the possibility and feasibility of using "ash-slag-asphalt-concrete" mixtures for pothole repair under both favorable and unfavorable weather conditions in different categories streets and roads, in various structural layers of road clothing structures (covering, base, additional base).
МАТЕМАТИЧНЕ ТА КОМП’ЮТЕРНЕ МОДЕЛЮВАННЯ КОНТАКТНОЇ ВЗАЄМОДІЇ ТРАНСВЕРСАЛЬНО-ІЗОТРОПНИХ ПРУЖНИХ ПІВПРОСТОРІВ ЗА ПРИСУТНОСТІ МІЖ НИМИ ЖОРСТКОГО ПЛОСКОГО ВКЛЮЧЕННЯ ДОВІЛЬНОЇ ФОРМИ
Authors:   Інститут механіки ім. С.П. Тимошенка НАН України, Кирилюк Віталій , Левчук Ольга ,   Інститут механіки ім. С.П. Тимошенка НАН України, Гавриленко Валерій ,   National Transport University, Вітер Михайло ,   National Transport University
Published: December 2022

Mathematical and computer modeling of the contact interaction of two transversely isotropic elastic half-spaces with different properties in the presence of a rigid flat inclusion between them under compression is carried out. Based on the representation of the general solution of the system of equilibrium equations for a transversally isotropic body in terms of harmonic functions, a correspondence is established between the contact interaction parameters for two transversely isotropic and two elastic isotropic half-spaces (in the presence of a rigid planar inclusion of an arbitrary shape between them), which generalizes Gladwell's result to the case interactions of transversely isotropic half-spaces. By means of the mathematical and computer modeling, the contact interaction of transversely isotropic half-spaces with a disk-like inclusion is studied. The analysis of the numerical results is carried out, the influence of the elastic properties of the half-space, the geometric dimensions of the inclusion on the parameters of the contact interaction is studied.