bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of risk factors associated with outpatient parenteral antimicrobial therapy complications
Authors: Kaul Christina , Yang Jenny , Haller Matthew , Solomon Sadie , Wang Yaojie , Wu Rong , Meng Yu , Pitts Robert , Phillips Michael
Published: May 2022

Background: Outpatient parenteral antimicrobial therapy (OPAT) is used in the outpatient setting to treat infectious conditions that require a prolonged course of antimicrobials. OPAT has been shown to decrease length of hospital stay and healthcare costs without compromising patient care and has become a widely accepted practice nationally. Due to this trend, the study of OPAT is of vital importance and will continue to be relevant moving forward. Currently, few studies have explored risk factors associated with OPAT complications, and most are limited in their analysis by indication. Further work should be performed to expand upon what is currently known. We characterized factors associated with increased OPAT complication risk. Methods: We conducted a retrospective cohort study at 4 sites across NYU Langone Health in patients admitted from 2017 to 2020. We applied the following inclusion criteria: aged ≥18 years and discharged with OPAT. Complications were defined as follows: vascular-access-related (line occlusion, thrombosis, dislodgement, central-line associated bloodstream infection or CLABSI) and antimicrobial-related (laboratory derangement, drug reaction, Clostridioides difficile infection), all-cause 30-day readmission, and OPAT-related readmission. Data were obtained from electronic medical records and the OPAT database. This study was granted a waiver from informed consent by the NYU Institutional Review Board. Multivariate logistic regression was performed, adjusting for confounding variables (sex, age, hospital of admission, history of chronic medical conditions, line type, and line duration). Results: Overall, 1,846 patient encounters of 5,951 reviewed met inclusion criteria. The median age was 66 (IQR, 26), 42.2% were female. Moreover, 810 (44%) received a peripherally inserted central catheter (PICC) and 1,036 (56%) received a midline cathether. Also, 563 (30.5%) were discharged to subacute rehabilitation (SAR). The most frequent complications were line dislodgement (4.2% of all patients), laboratory derangement (3.0%), and drug reaction (2.4%). Furthermore, 27 patients (1.5%) developed CLABSI. Patients discharged to SAR were more likely to develop CLABSI (OR, 4.1l; P = .005), and they had higher rates of OPAT-related 30-day readmissions (OR, 2.675; P = .004) compared to those who were discharged home, after adjusting for key confounders. Conclusions: Discharge to SAR is strongly associated with increased risk of readmission for OPAT-related complications and CLABSI, after adjusting for key confounders. CLABSI prevention during SAR admission is a critically needed public health intervention.

Funding: None

Disclosures: None
With Great (Computing) Power Comes Great (Human Rights) Responsibility: Cloud Computing and Human Rights
Authors: Krishnamurthy Vivek
Published: May 2022

Cloud computing underlies many of the most powerful and controversial technologies of our day – from large-scale data processing to face recognition systems – yet the human rights impacts of cloud computing have received little scrutiny. This article explains what cloud computing is, how it works, and what some of its most significant human rights impacts are through three case studies. It offers some initial thoughts on the human rights responsibilities of cloud computing providers under the United Nations Guiding Principles on Business and Human Rights and concludes by suggesting directions for future research.
Express Trusts, Private Law Theory, and Legal Concepts
Authors: Sheehan Duncan
Published: May 2022

This paper explores Peter Jaffey’s views on the trust and fusion and some aspects of his wider private law theory which impact on his view on trusts law. It shows that, although he is correct that the trust involves both proprietary and personal rights, in the end his theory is ahistorical and unDworkinian, despite his acceptance of a view of law based on Dworkin. His theory is also based on implausible views of the role of equity post-Judicature Acts and the ownership of value and does not adequately fit how trusts law works.
Using informatics to advance translational science: Environmental scan of adaptive capacity and preparedness of Clinical and Translational Science Award Program hubs
Authors: Ragon Bart , Volkov Boris B. , Pulley Chris , Holmes Kristi
Published: May 2022

As the USA and the rest of the world raced to fight the COVID-19 pandemic, years of investments from the National Center for Advancing Translational Sciences allowed for informatics services and resources at CTSA hubs to play a significant role in addressing the crisis. CTSA hubs partnered with local and regional partners to collect data on the pandemic, provide access to relevant patient data, and produce data dashboards to support decision-making. Coordinated efforts, like the National COVID Cohort Collaborative (N3C), helped to aggregate and harmonize clinical data nationwide. Even with significant informatics investments, some CTSA hubs felt unprepared in their ability to respond to the fast-moving public health crisis. Many hubs were forced to quickly evolve to meet local needs. Informatics teams expanded critical support at their institutions which included an engagement platform for clinical research, COVID-19 awareness and education activities in the community, and COVID-19 data dashboards. Continued investments in informatics resources will aid in ensuring that tools, resources, practices, and policies are aligned to meet local and national public health needs.
Adapting an Expanded Access program to enable investigational treatments for COVID-19
Authors: Samuels Elias , Champagne Ellen , Gravelin Misty , Racklyeft Jamie , Weatherwax Kevin
Published: May 2022

Retrospective case studies of initiatives supported by the National Institutes of Health’s Clinical and Translational Science Award (CTSA) hubs can be used to identify facilitators and barriers of translational science. This case study investigates how a CTSA Expanded Access program adapted to changing FDA guidance issued in 2020 to support clinicians’ treatment of COVID-19 patients in Michigan. We studied how this program changed throughout the pandemic to support physicians’ requests for remdesivir, convalescent plasma, and other uses of unapproved drugs and novel medical devices. A protocol for retrospective translational science case studies of health interventions developed by CTSA evaluators was used for this case study. Data collection methods included seven interviews and a review of institutional data, peer-reviewed publications, news stories, and other public records. The barriers identified include evolving guidance, misalignment of organizational operations, and the complexity of the research infrastructure. The facilitators of translation include collaboration between research and care teams, increasing engagement with a broad network of supporters, and ongoing professional development for research staff. The findings of this case study can be used to inform future investigations of the principles underlying the translational process.
Exact calculation of corrosion rates by the weight-loss method
Authors: Malaret Francisco
Published: May 2022

Corrosion is an important problem that engineers and scientists must overcome to avoid the collapse of structures, chemical processing plants, and metallic objects, which can lead to not only economic loss but also environmental and human losses. One of the simplest and most widely used methods to quantify corrosion rates (CRs) is the immersion test. The usual approach that has been used to date, to quantify the CR by this method, is to assume that the initial surface area of the corroding object remains constant over time. It is shown that such approximations underestimate the true CR and that they may lead to significant errors. A formula to calculate the CR considering changes in the area is presented in this work. The formula herein can be used to accurately quantify the CR by the immersion test and improve the quality of experimental data and the analysis and modeling of corrosion phenomena.
Hensel minimality I
Authors: Cluckers Raf , Halupczok Immanuel , Rideau-Kikuchi Silvain
Published: May 2022

We present a framework for tame geometry on Henselian valued fields, which we call Hensel minimality. In the spirit of o-minimality, which is key to real geometry and several diophantine applications, we develop geometric results and applications for Hensel minimal structures that were previously known only under stronger, less axiomatic assumptions. We show the existence of t-stratifications in Hensel minimal structures and Taylor approximation results that are key to non-Archimedean versions of Pila–Wilkie point counting, Yomdin’s parameterization results and motivic integration. In this first paper, we work in equi-characteristic zero; in the sequel paper, we develop the mixed characteristic case and a diophantine application.
Undertaking a face-to-face objective structured clinical examination for medical students during the COVID-19 pandemic
Authors: Fitzgerald N. , Moylett E. , Gaffney G. , McCarthy G. , Fapohunda O. , Murphy A. W. , Geoghegan R. , Hallahan B.
Published: May 2022

Introduction and aims:

Objective structured clinical examinations (OSCEs) play a pivotal role in medical education assessment. The Advanced Clinical Skills (ACS) OSCE examines clinical skills in psychiatry, general practice, obstetrics and gynaecology and paediatrics. This study examined if the 2020 ACS OSCE for fourth year medical students attending the National University of Ireland, Galway, was associated with any significant result differences compared to the equivalent 2019 OSCE. Additionally, we assessed students’ satisfaction and explored any organisational difficulties in conducting a face-to-face OSCE during the COVID-19 pandemic.

Materials and methods:

This study compared anonymised data between the 2019 and 2020 ACS OSCEs and analysed anonymised student feedback pertaining to the modified 2020 OSCE.

Results:

The mean total ACS OSCE result achieved in 2020 was statistically higher compared to the 2019 OSCE [62.95% (SD = 6.21) v. 59.35% (SD = 5.54), t = 6.092, p < 0.01], with higher marks noted in psychiatry (p = 0.001), paediatrics (p = 0.001) and general practice (p < 0.001) with more students attaining honours grades (χ2 = 27.257, df = 3, p < 0.001). No difference in failure rates were found. Students reported feeling safe performing the 2020 OSCE (89.2%), but some expressed face-mask wearing impeded their communication skills (47.8%).

Conclusion:

This study demonstrates that conducting a face-to-face OSCE during the pandemic is feasible and associated with positive student feedback. Exam validity has been demonstrated as there was no difference in the overall pass rate.
dastanandtuwān, Adjectives or Nouns? A Discussion about Their Grammatical Category and Meaning in Middle Persian
Authors: Jalalian Chaleshtari Mohammad Hasan
Published: May 2022

Despite the impressive research of scholars on Middle Persian grammatical problems, there are still many words in surviving texts that are shrouded in ambiguity. One of these words, whose pronunciation in the inscriptions we owe to the Manichaean texts, isdastan. In this article, first the few available instances of this word in Middle Persian inscriptions and Manichaean texts are mentioned, and scholars’ interpretations of its meaning and grammatical category are discussed. Then it is revisited through the analysis of another word,tuwān, with which it is paired in the Manichaean instance. After a review of prior scholarly interpretations of this latter word, it is argued that in Middle Persiantuwānis a noun, and that it became a modal verb during the process of its application to the possessive structure. Finally, it is asserted thatdastanalso is a noun, due to its conjoinment withtuwānin the Manichaean example.
Creation of quantum knots and links driven by minimal surfaces
Authors: Zuccher Simone , Ricca Renzo L.
Published: May 2022

Using an improved numerical code we investigate the creation and evolution of quantum knots and links as defects of the Gross–Pitaevskii equation. The particular constraints put on quantum hydrodynamics make this an ideal context for application of geometric and topological methods to investigate dynamical properties. Evolutionary processes are classified into three generic scenarios representing (i) direct topological cascade and collapse, (ii) structural and topological cycles, and (iii) inverse topological cascade of complex structures. Several examples and test cases are studied; the head-on collision of quantum vortex rings and the creation of a trefoil knot from initially unlinked, unknotted loops are realized for the first time. Each type of scenario is studied by carrying out a detailed evaluation of fundamental geometric and dynamical properties associated with evolution. Direct topological cascade that governs the decay of complex structures to small-scale vortex rings is identified by writhe measures, while picks of total curvature are found to provide a clear signature of reconnection events. We demonstrate that isophase minimal surfaces spanning knots and links have a privileged role in the decay process by detecting surface energy relaxation of complex structures. Minimal surfaces are shown to be critical markers for energy and prove to be appropriate detectors for the evolution of complex systems.
Estimation of ice ablation on a debris-covered glacier from vertical debris-temperature profiles
Authors: Laha Sourav , Winter-Billington Alex , Banerjee Argha , Shankar R. , Nainwal H.C , Koppes Michele
Published: May 2022

A supraglacial debris layer controls energy transfer to the ice surface and moderates ice ablation on debris-covered glaciers. Measurements of vertical temperature profiles within the debris enables the estimation of thermal diffusivities and sub-debris ablation rates. We have measured the debris-layer temperature profiles at 16 locations on Satopanth Glacier (central Himalaya) during the ablation seasons of 2016 and 2017. Debris temperature profile data are typically analysed using a finite-difference method, assuming that the debris layer is a homogeneous one-dimensional thermal conductor. We introduce three more methods for analysing such data that approximate the debris layer as either a single or a two-layered conductor. We analyse the performance of all four methods using synthetic experiments and by comparing the estimated ablation rates with in situ glaciological observations. Our analysis shows that the temperature measurements obtained at equispaced sensors and analysed with a two-layered model improve the accuracy of the estimated thermal diffusivity and sub-debris ablation rate. The accuracy of the ablation rate estimates is comparable to that of the in situ observations. We argue that measuring the temperature profile is a convenient and reliable method to estimate seasonal to sub-seasonal variations of ablation rates in the thickly debris-covered parts of glaciers.
The effects of dietary linoleic acid on reducing serum cholesterol and atherosclerosis development are nullified by a high-cholesterol diet in male and female apoE-deficient mice
Authors: Yuan Xingyu , Nagamine Rika , Tanaka Yasutake , Tsai Wei-Ting , Jiang Zhe , Takeyama Ai , Imaizumi Katsumi , Sato Masao
Published: May 2022

Linoleic acid (LA) has a two-sided effect with regard to serum cholesterol-lowering and pro-inflammation, although whether this fatty acid reduces serum cholesterol and the development of atherosclerosis under high-cholesterol conditions has yet to be ascertained. In this study, we examine the effects of dietary LA on reducing serum cholesterol and atherosclerosis development under high-cholesterol conditions. Male and female apoE-deficient (ApoE-/-) mice were fed AIN-76-based diets containing 10% SFA and 0·04 % cholesterol, 10% LA and 0·04% low cholesterol (LALC), or 10% LA and 0·1% high cholesterol (LAHC) for 9 weeks. The results revealed significant reduction in serum cholesterol levels and aortic lesions with increasing levels of pro-inflammatory biomarkers (urinary isoprostane and aortic MCP-1 mRNA) in male and female LALC groups compared with those in the SFA groups (P < 0·05). Furthermore, whereas there were significant increases in the serum cholesterol levels and aortic lesions (P < 0·05), there was no difference in aortic MCP-1 mRNA levels in male and female LAHC groups compared with those in the LALC groups. A high-dietary intake of cholesterol eliminated the serum cholesterol-lowering activity of LA but had no significant effect on aortic inflammation in either male or female ApoE-/- mice. The inhibitory effect of LA on arteriosclerosis is cancelled by a high-cholesterol diet due to a direct increase in serum cholesterol levels. Accordingly, serum cholesterol levels might represent a more prominent pathogenic factor than aortic inflammation in promoting the development of atherosclerosis.
Mind the adoption gap: Findings from a field experiment designed to scale up the availability of fodder shrub seedlings in Malawi
Authors: Hughes Karl , Kulomo Decolius , Nyoka Betserai
Published: May 2022

While dairy production has the potential to diversify smallholder agriculture and increase incomes, there are multiple constraints. One is the consistent provision of quality feed. High protein, leguminous fodder shrubs – also referred to as Fodder Tree Technology (FTT) – can help address this constraint, yet adoption levels are generally low. Implemented in Kenya and Malawi, the Shrubs for Change (S4C) project is employing several approaches to address this situation, including those informed by behavioral science. Given that approximately 500 shrubs per cow are needed to generate enough leaf matter to bolster milk production, promoting FTT at scale necessitates the production, distribution, and successful planting of large numbers of shrub seedlings. We implemented a field experiment in Malawi’s Southern Region in late 2021 to test the effectiveness of a social learning intervention intended to motivate dairy farmers to significantly scale up the production of FTT seedlings. This intervention involved meeting with dairy farmers in 39 randomly selected milk production zones to review the numbers of seedlings being produced vis-à-vis local demand, coupled with the development of action plans to address identified production gaps. While we find that this intervention increased the setting up of private nurseries by 10% (p < 0.05), it only increased overall seedling production by an average of 20 additional seedlings per dairy farmer (p > 0.1). We offer several explanations for this lower than expected and statistically insignificant result, which point to the need for iterative rounds of engagement with farmers when supporting them to take up FTT and other complex agronomic and sustainable land management innovations.
Between Church and State: The Challenges of Reforming the Church Courts and Family Law in the Greek Orthodox Patriarchate of Jerusalem
Authors: Engelcke Dörthe
Published: May 2022

In most Middle Eastern jurisdictions, the applicable family law is determined based on the religious affiliation of the parties involved. Whereas Jordanian Islamic family law has last been reformed in 2001, 2010, and 2019, and the law that regulates the shariʿa courts has been amended several times since 1972, the family laws of Christian communities and the church courts have largely been exempted from this reform dynamic. Based on semi-structured interviews as well as the review of written sources, this article investigates why it is difficult to reform the church courts and even more difficult to reform the family laws of Christian communities, using the Greek Orthodox community in Jordan as a case study. I argue that conflicts within the Greek Orthodox Patriarchate of Jerusalem and the fact that the jurisdiction of the patriarchate over family law transcends Jordanian state boundaries have made state-led reform challenging and presented obstacles for Jordanian Christians lobbying for change.
Exploring the Relationship between Household Structure and Utilisation of Maternal Health Care Services in India
Authors: Pradhan Manas Ranjan , Mondal Sourav
Published: May 2022

The role of household structure, especially the mother-in-law (MIL) influencing daughter-in-law’s maternal health care (MHC) seeking behaviour, has been a continuing debate due to the former’s advantageous position in the household. This study assesses the association of household structure and particularly the presence of MIL with MHC utilisation in India using the National Family Health Survey-4 data (2015-16). The sample of women aged 15-49 years who have given birth during the last five years preceding the survey (n=184,641) was considered for analysis. The outcome variables were full-antenatal care, institutional delivery, and postnatal care. Binary logistic regression was used to check the adjusted effects of the household structure on MHC utilisation. The analyses were done with STATA (version 13) with a significance level of 5%. Adjusting the effects of socio-demographic and economic characteristics, women from non-nuclear households with MIL had higher odds of full-antenatal care (OR= 1.04, CI= 0.99-1.08) and institutional delivery (OR=1.05, CI=1.01- 1.10) than their counterparts from nuclear households. Women from non-nuclear households without MIL had lower chances of postnatal care (OR=0.98, CI=0.96-1.00) than those from nuclear households. The study unearths a very weak association between the presence of MIL in the household and MHC services utilisation of the daughter-in-law, a notable change from the earlier literature often portraying MIL as a barrier.
Schistosoma mansoni miracidia: revisiting motility and survival parameters for improved computational modelling
Authors: de Souza Renata Perotto , Pascoal Vanessa Fey , Vilches Thomas Nogueira , Bittencourt Hélio Radke , Utz Laura Roberta Pinto , Graeff-Teixeira Carlos
Published: May 2022

Schistosoma mansoni is the main causative agent of intestinal schistosomiasis which affects millions of people worldwide. At the larval stage, miracidia are released into bodies of water where they utilize their motility to successfully infect their intermediate host, snails. Here, we revisit the motility and survival of S. mansoni miracidia throughout its life span. Briefly, miracidia motility was monitored at 30-min and 60-min intervals under the presence/absence of natural/artificial light. Based on a subjective evaluation of activity, body shape and transparency, 6 categories of miracidia activity were established from its fully active stage to its immobile larva stage. The estimated life span of miracidia was 5.8 and 3.5 h in the experiments with 60-min and 30-min observation intervals, respectively. Death was defined by an absence of cilia and body movement. When mobility was used as a proxy for infectivity, infective miracidia were detected at 2.5 and 4.5 h, respectively. The present miracidia motility and survival re-evaluation supports parameters optimization for computational modelling of schistosomiasis transmission dynamics. Target control interventions, especially at late stages next to transmission interruption, may greatly benefit from improved modelling studies.
Haemosporidian infections in wild populations of Podarcis muralis from the Italian Peninsula
Authors: Storniolo Federico , Zuffi Marco A. L. , Coladonato Alan J. , Mangiacotti Marco , Scali Stefano , Sacchi Roberto
Published: May 2022

Parasites can significantly influence the ecology, behaviour and physiology of their hosts sometimes with remarkable effects on their survivorship. However, endemic parasites or those not associated with obvious clinical disease have been partly neglected in the past decades comparatively to the most pathogenic ones. Apicomplexa are an important example of blood parasites that have been broadly investigated, although it can be difficult to determine the effects of infections at the population level, especially in widespread species. Such is the case of the common wall lizard (Podarcis muralis). We investigated 61 populations across Italy between 2008 and 2017 and recorded snout–vent length, latitude, date of collection and took blood samples for parasite count. We modelled parasite prevalence and load in a Bayesian framework. Parasites were present in all populations but 1 and in 13 of them all individuals were parasitized. We recorded almost identical responses for probability of infection and parasite load in both sexes, directly proportional to body size and inversely proportional to latitude, with a peak in cooler months. Therefore, haemosporidians can be very common in P. muralis, although their presence can vary significantly. Moreover, such a high prevalence makes it necessary to investigate to what extent haemosporidians affect hosts' survivorship, taking into consideration abiotic and biotic factors such as temperature, hormone levels and immune response.
Effects of nest-box environment on fledgling success rate and pathogen load
Authors: Scott-Baumann James F. , Morgan Eric R. , Cogan Tristan A.
Published: May 2022

Nest boxes have been used for many decades as tools for conservation and to study avian population dynamics. Plastic is increasingly used as a material for nest boxes, but no studies have investigated effects of this different material. Two consecutive studies were conducted to investigate effects of nest-box environment on nidicolous parasites, bacteria and fungi, as well as nest success, in blue tits Cyanistes caeruleus and great tits Parus major. The first compared microclimate and parasite and pathogen load in plastic and wooden nest boxes. The second tested the nest protection hypothesis – that birds naturally incorporate aromatic herbs into nests to decrease nest parasites and pathogens – by comparing parasite and pathogen load in plastic nest boxes to which aromatic or non-aromatic plant material was added. No significant difference in nest-box temperature or relative humidity was found between plastic and wooden boxes. Wooden boxes, however, contained 30-fold higher numbers of fleas and a higher total bacterial load on chicks. Fledging success for blue tit broods was significantly higher in wooden boxes. Parasites and bacteria did not decrease by the inclusion of aromatic herbs. The results increase the evidence base for nest-box design in support of plastic, which can provide an appropriate alternative nest-box material to wood, with apparently no difference in microclimate and no increase in the load of measured parasites and pathogens.
Digging into the biophysical features of cell membranes with lipid-DNA conjugates
Authors: Ali Ahsan Ausaf , Bagheri Yousef , You Mingxu
Published: May 2022

Lipid-DNA conjugates have emerged as highly useful tools to modify the cell membranes. These conjugates generally consist of a lipid anchor for membrane modification and a functional DNA nanostructure for membrane analysis or regulation. There are several unique properties of these lipid-DNA conjugates, especially including their programmability, fast and efficient membrane insertion, and precise sequence-specific assembly. These unique properties have enabled a broad range of biophysical applications on live cell membranes. In this review, we will mainly focus on recent tremendous progress, especially during the past three years, in regulating the biophysical features of these lipid-DNA conjugates and their key applications in studying cell membrane biophysics. Some insights into the current challenges and future directions of this interdisciplinary field have also been provided.
The relation of second language acquisition, instructed second language acquisition, and language teaching from the lens of second language tense-aspect
Authors: Bardovi-Harlig Kathleen , Comajoan-Colomé Llorenç
Published: May 2022

This article examines the relationships between second language acquisition (SLA), instructed second language acquisition (ISLA), and language teaching by examining them from the lens of the research on the acquisition and teaching of second language (L2) tense-aspect in the last 20 years (2000–2021). Review 1 examines 56 instructional effect studies on the acquisition of L2 tense-aspect, and Review 2 examines 38 pedagogical proposals for the teaching of L2 tense-aspect. The reviews investigate to what extent instructional effect studies and pedagogical proposals with tense-aspect as the target of investigation and instruction (a) provide a linguistic description of the instructional target, (b) engage with previous research, (c) implement results from previous research to design assessment or instruction, and (d) include elaborate descriptions of teaching interventions and teaching materials. The results show that there are clear attempts to establish connections between research and practice. However, neither instructional effect studies nor pedagogical proposals always engage with the SLA literature on the acquisition of tense-aspect; nor do they engage fully with language teaching.
Diversity patterns of lizard assemblages from a protected habitat mosaic in the Brazilian Cerrado savanna
Authors: Barros Rafael Assis , Dorado-Rodrigues Tainá Figueras , Valadão Rafael Martins , Strüssmann Christine
Published: May 2022

Differences in habitat complexity and structure can directly influence the composition, diversity, and structure of species assemblages. Measurements of functional and phylogenetic diversity complement the commonly used measurements of taxonomic diversity, elucidating the relationships between species, their traits, and their evolutionary history. In this study, we evaluated how the mosaic of open and forested formations in a federal conservation unit in the western portion of the Brazilian Cerrado savanna influences the taxonomic, functional, and phylogenetic structure of lizard assemblages. Lizards were sampled for 15 months using pitfall traps set in open and forested formations. We recorded 292 lizards distributed among 16 species from eight families, with species composition differing among the formations. Richness was greater in the assemblages from open formations, while functional diversity and phylogenetic variability were greater in those of forested formations. Lizard assemblages in open formations were functionally and phylogenetically clustered, probably as a result of environmental filters acting on species, while the assemblages from forested formations were randomly structured. Different environmental and historical mechanisms have apparently shaped the current diversity of lizards in the region. This study shows that Cerrado vegetation mosaics can promote wide variation in different aspects of the taxonomic, functional, and phylogenetic structure from the lizard assemblages.
Evaluation of the left ventricular systolic function and myocardial deformation by real-time three-dimensional (four-dimensional) and speckle-tracking echocardiography in children with type 1 diabetes mellitus
Authors: Eroğlu Ayşe G. , Yüksel Esra K. , Karagözlü Fatih , Acar Hazal C. , Gökalp Selman , Evliyaoğlu Olcay
Published: May 2022

Aim:

This study aimed to evaluate the role of real-time three-dimensional (known as four-dimensional) echocardiography and three-dimensional speckle-tracking echocardiography for the early detection of left ventricular systolic dysfunction in asymptomatic children with type 1 diabetes mellitus.

Materials and method:

This cross-sectional study included 38 patients (mean age 15.4 ± 2.9, 42.1% male) and 38 age, gender, and body measurements matched healthy children. Each patient underwent an interview about medical history, a detailed clinical examination, blood laboratory tests, conventional echocardiography, and tissue Doppler imaging. Left ventricular ejection fraction; global longitudinal, circumferential, radial strain; twist; and torsion were measured by real-time three-dimensional and speckle-tracking echocardiography.

Results:

Conventional echocardiography and tissue Doppler imaging showed normal left ventricular systolic function in the patients. Although left ventricular ejection fraction (61.6 ± 1.4%, 61.8 ± 1.1%, p = 0.386), global longitudinal [−26.6 (−27.7 to −26.1)%, −26.2 (−27.7 to −24.9)%, p = 0.224], and radial strain [44.4 (42.4–45.9)%, 43.9 (41–46.1)%, p = 0.513] were similar to the controls, circumferential strain (−27.3 ± 1.3%, −28.0 ± 1.6%, p = 0.048) and twist (9.5 ± 2.3°, 11.4 ± 3.0°, p = 0.003) were decreased in the patients compared with controls.

Conclusion:

We found that even in children with asymptomatic type 1 diabetes mellitus with normal left ventricular ejection fraction, circumferential function was impaired and rotation pattern was changed. This novel echocardiographic method might be an important tool for detecting left ventricular systolic dysfunction in type 1 diabetes mellitus children before it becomes overt on conventional echocardiography and tissue Doppler imaging.
Performance of a single-ventricle home-monitoring programme: survival and predictors of adverse outcome
Authors: Lillitos Peter J. , Rittey Leila , Vass Madeleine , Ugwoke Gerald , Akhtar Muhammad , Barwick Shuba , Van Doorn Carin , Jaber Osama , Bentham James R.
Published: May 2022

Introduction and background:

Mortality between stages 1 and 2 single-ventricle palliation is significant. Home-monitoring programmes are suggested to reduce mortality. Outcomes and risk factors for adverse outcomes for European programmes have not been published.

Aims:

To evaluate the performance of a home-monitoring programme at a medium-sized United Kingdom centre with regards survival and compare performance with other home-monitoring programmes in the literature.

Methods:

All fetal and postnatal diagnosis of a single ventricle were investigated with in-depth analysis of those undergoing stage 1 palliation and entered the home-monitoring programme between 2016 and 2020. The primary outcome was survival. Secondary outcomes included multiple parameters as potential predictors of death or adverse outcome.

Results:

Of 217 fetal single-ventricle diagnoses during the period 2016–2020, 50.2% progressed to live birth, 35.4% to stage 1 and 29.5% to stage 2. Seventy-four patients (including 10 with postnatal diagnosis) entered the home-monitoring programme with six deaths making home-monitoring programme mortality 8.1%. Risk factors for death were the hybrid procedure as the only primary procedure (OR 33.0, p < 0.01), impaired cardiac function (OR 10.3, p < 0.025), Asian ethnicity (OR 9.3, p < 0.025), lower mean birth-weight (2.69 kg versus 3.31 kg, p < 0.01), and lower mean weight centiles during interstage follow-up (mean centiles of 3.1 versus 10.8, p < 0.01)

Conclusion:

Survival in the home-monitoring programme is comparable with other home-monitoring programmes in the literature. Hybrid procedure, cardiac dysfunction, sub-optimal weight gain, and Asian ethnicity were significant risk factors for death. Home-monitoring programmes should continue to raise awareness of these factors and seek solutions to mitigate adverse events. Future work to generalise home-monitoring programme and single-ventricle fetus to stage 2 outcomes in the United Kingdom will require multi-centre collaboration.
Multilevel exploration of individual- and community-level factors contributing to overweight and obesity among reproductive-aged women: a pooled analysis of Bangladesh Demographic and Health Survey, 2004–2018
Authors: Ahammed Benojir , Sarder Md. Alamgir , Kundu Subarna , Keramat Syed Afroz , Alam Khorshed
Published: May 2022

Objectives:

Overweight and obesity have been related to a variety of adverse health outcomes. Understanding the overweight and obesity epidemic in Bangladesh, particularly among reproductive-aged women, is critical for monitoring and designing effective control measures. The purpose of this study was to determine the prevalence of overweight and obesity in reproductive-aged women and to identify the risk factors of overweight and obesity.

Design:

A total of 70 651 women were obtained from the five most recent and successive Bangladesh Demographic and Health Surveys (BDHS). The multilevel logistic regression model was used to explore the individual- and community-level factors of overweight and obesity.

Setting:

Five most recent nationally representative household surveys across all regions.

Participants:

Reproductive-aged (15–49 years) non-pregnant women.

Results:

Approximately 35·2 % (95 % CI: 34·9–35·6 %) of women were either overweight or obese in Bangladesh. At the individual- and community-level, higher age (adjusted odds ratio (aOR) = 5·79, 95 % CI: 5·28–6·34), secondary or higher education (aOR = 1·69 [1·60–1·78]), relatively wealthiest households (aOR = 4·41 [4·10–4·74]), electronic media access (aOR = 1·32 [1·26–1·37]) and community high literacy (aOR = 1·10 [1·04–1·15]) of women were significantly positively associated with being overweight or obese. Whereas, rural residents (aOR = 0·79 [0·76–0·82]) from larger-sized households (aOR = 0·80 [0·73–0·87]) and have high community employment (aOR = 0·92 [0·88–0·97]) were negatively associated with the probability of being overweight or obese.

Conclusion:

Individual- and community-level factors influenced the overweight and obesity of Bangladeshi reproductive-aged women. Interventions and a comprehensive public health plan aimed at identifying and addressing the growing burden of overweight and obesity should be a top focus.
Temporal patterns of sleep and eating among children during school closure in Japan due to COVID-19 pandemic: associations with lifestyle behaviours and dietary intake
Authors: Sugimoto Minami , Murakami Kentaro , Sasaki Satoshi
Published: May 2022

Objective:

To identify temporal patterns of sleep and eating among school-age children during school closure due to the COVID-19 pandemic and to examine their associations with lifestyle behaviours and dietary intake.

Design:

In this cross-sectional study, questionnaires were used to assess sleep and eating times, lifestyle behaviours and dietary intake during school closure. Latent class analysis was performed to identify temporal patterns of sleep and eating based on self-reported clock times for wake-up, going to bed and eating meals. Lifestyle behaviours and dietary intake were compared between latent classes.

Setting:

Forty-eight primary and secondary schools in Japan.

Participants:

Totally, 6220 children (aged 8–15 years).

Results:

Four patterns, labelled ‘Very early (20 % of children)’, ‘Early (24 %)’, ‘Late (30 %)’ and ‘Very late (26 %),’ were identified and ordered according to the circadian timing. Latter patterns were characterised by later timings of sleep and eating, especially in clock times for wake-up, breakfast and lunch compared with earlier patterns. Children with latter patterns had a less physically active lifestyle, longer screen time (≥4 h/d), shorter study time (<2 h/d) and more frequent skipping of breakfast and lunch than those with earlier patterns. In addition, children with latter patterns had lower intakes of several vitamins, vegetables, fruits, fish and shellfish and dairy products and higher intakes of sugar and confectionaries and sweetened beverages.

Conclusion:

More than half of the participants had later wake-up, breakfast and lunch during school closure, which was associated with more unfavourable lifestyles and dietary intakes.
Rural disparities in head and neck cancer from 2017 to 2021: a single institution analysis
Authors: Nguyen My-Lien , Derouen Jonathan T. , Cantrell J. Nathan , Johnston Andrea , Vidal Gabriel , Schutz Alexis , Ogilvie William , Businelle Michael , Ahmad Salahuddin , Henson Christina
Published: May 2022

Introduction:

This study aims to look at the trends in our head and neck cancer patient population over the past 5 years with an emphasis on the past 2 years to evaluate how the coronavirus disease 2019 (COVID-19) pandemic has impacted our disparities and availability of care for patients, especially those living in rural areas. An additional aim is to identify existing disparities at our institution in the treatment of head and neck patients and determine solutions to improve patient care.

Materials and Methods:

A retrospective chart review was performed to identify patients who were consulted and subsequently treated with at least one fraction of radiation therapy at our institution with palliative or curative intent. Patient demographic information was collected including hometown, distance from the cancer centre based on zip-codes and insurance information and type of appointment (in-person or telehealth). Rural–urban continuum codes were used to determine rurality.

Results:

A total of 490 head and neck cancer patients (n = 490) were treated from 2017 to 2021. When broken down by year, there were no significant trends in patient population regarding travel distance or rurality. Roughly 20–30% of our patients live in rural areas and about 30% have a commute > 50 miles for radiation treatment. A majority of our patients rely on public insurance (68%) with a small percentage of those uninsured (4%). Telehealth visits were rare prior to 2019 and rose to 5 and 2 visits in 2020 and 2021, respectively.

Conclusions:

Head and neck cancer patients, despite rurality or distance from a cancer centre, may present with alarmingly enough symptoms despite limitations and difficulties with seeking medical attention even during the COVID-19 pandemic in 2020. However, providers must be aware of these potential disparities that exist in the rural population and seek to address these.
What is IHL history now?
Authors: van Dijk Boyd
Published: May 2022

Over the last few decades, an extraordinary amount has changed in our understanding of the history of international humanitarian law (IHL). This article addresses the latest findings in this new historiography, placing contemporary IHL issues in a broader historical context and sharing the author's own experiences as a researcher exploring the discipline's practice from a historical perspective. Ultimately, he makes a passionate case for history – by showing why this discipline has a lot to offer for practitioners of international law.
Climate Controls on River Chemistry
Authors: Li Li , Stewart Bryn , Zhi Wei , Sadayappan Kayalvizhi , Ramesh Shreya , Kerins Devon , Sterle Gary , Harpold Adrian , Perdrial Julia
Published: May 2022

How does climate control river chemistry? Existing literature has examined extensively the response of river chemistry to short‐term weather conditions from event to seasonal scales. Patterns and drivers of long‐term, baseline river chemistry have remained poorly understood. Here we compile and analyze chemistry data from 506 minimally impacted rivers (412,801 data points) in the contiguous United States (CAMELS‐Chem) to identify patterns and drivers of river chemistry. Despite distinct sources and diverse reaction characteristics, a universal pattern emerges for 16 major solutes at the continental scale. Their long‐term mean concentrations (Cm) decrease with mean discharge (Qm), with elevated concentrations in arid climates and lower concentrations in humid climates, indicating overwhelming regulation by climate compared to local Critical Zone characteristics such as lithology and topography. To understand the CmQm pattern, a parsimonious watershed reactor model was solved by bringing together hydrology (storage–discharge relationship) and biogeochemical reaction theories from traditionally separate disciplines. The derivation of long‐term, steady state solutions lead to a power law form of CmQm relationships. The model illuminates two competing processes that determine mean solute concentrations: solute production by subsurface biogeochemical and chemical weathering reactions, and solute export (or removal) by mean discharge, the water flushing capacity dictated by climate and vegetation. In other words, watersheds function primarily as reactors that produce and accumulate solutes in arid climates, and as transporters that export solutes in humid climates. With space‐for‐time substitution, these results indicate that in places where river discharge dwindles in a warming climate, solute concentrations will elevate even without human perturbation, threatening water quality and aquatic ecosystems. Water quality deterioration therefore should be considered in the global calculation of future climate risks.
A Novel Proxy for Tracking the Provenance of Dust Based on Paired E1’‐Peroxy Paramagnetic Defect Centers in Fine‐Grained Quartz
Authors: Dave Aditi K. , Timar‐Gabor Alida , Kabacińska Zuzanna , Scardia Giancarlo , Safaraliev Nosir , Nigmatova Saida , Fitzsimmons Kathryn E.
Published: May 2022

Crystal lattice defects in quartz have long been exploited for age determination, yet also show potential for sediment provenance studies. Here, we introduce a novel method for tracking aeolian dust provenance by utilizing the natural accumulation of E1’ and peroxy defect centers in quartz. Our approach is based on the previously observed premise that E1’ and peroxy centers arise from Frenkel defect pairs, and that their concentration increases with the age of the quartz‐bearing source rock. We propose that these defect centers can be utilized as a characteristic feature of the source rock and consequently, for fingerprinting sediments derived from it. We successfully apply our new protocol to distinguish fine‐grained quartz extracted from loess deposits from two regions in Central Asia which are known to derive from different source material of differing age. Our method offers strong potential for identifying variability in source, both spatially and through time down sedimentary sequences.
Influence of Anthropogenic Activities on Elevation‐Dependent Weakening of Annual Temperature Cycle Amplitude Over the Tibetan Plateau
Authors: Zhu Lihua , Huang Gang , Fan Guangzhou , Hua Wei
Published: May 2022

The annual cycle is the dominant component and the most prominent climate oscillation for the temperature variation over the Tibetan Plateau (TP). Identifying the relative contribution of anthropogenic and natural forcing to the changes in the annual cycle, namely, detection and attribution, is an important aspect for mountainous climate change research. The present study documents the elevation dependence of the trend in the annual temperature cycle (ATC) amplitude over the TP and detects the influence of anthropogenic activities on it. An elevation‐dependent weakening of the ATC amplitude occurs over the TP during the period 1961–2014. This variation with altitude can mainly be ascribed to the seasonal difference in warming. The influence of anthropogenic activities is detectable, with increased aerosols being the main contributor. Under aerosol‐only forcing, the larger decrease in snow‐related albedo at higher altitudes in winter can explain the amplified negative tendency of the ATC amplitude with elevation.
Assimilation of Aeolus Rayleigh‐Clear Winds Using a Footprint Operator in AROME‐Arctic Mesoscale Model
Authors: Mile Máté , Azad Roohollah , Marseille Gert‐Jan
Published: May 2022

The wind profiles measured by the Aeolus satellite mission are unique and valuable wind products for numerical weather prediction. However, just like any other remote sensing measurements, it has a footprint extending over a number of model grid cells, especially in high‐resolution mesoscale models. The spatial representation of Aeolus Rayleigh‐clear observations has been assessed in a mesoscale limited‐area model called AROME‐Arctic by using a footprint observation operator. The footprint representation provides small, but consistent reduction in the standard deviation of background departures and an observing system experiment comparing the default and the footprint operator based on Aeolus data assimilation showed a small positive impact on AROME‐Arctic forecasts.