bluuebunny/crossref_metadata_2025 huggingface dataset:
Immunoassay standardization for the detection of immunoglobulin A (IgA) against Porphyromonas gingivalis antigens in saliva of individuals with and without leprosy
Authors: Calheira Mariana Costa , Trindade Soraya Castro , Falcão Michelle Miranda Lopes , Barbosa Luciana Sales Conceição , Carvalho Gislene Regina Batista , Machado Paulo Roberto Lima , Gomes-Filho Isaac Suzart , Campos Elisangela de Jesus , de Carvalho-Filho Paulo Cirino , Xavier Márcia Tosta , de Farias Antonio Pedro Fróes , Filho José Tadeu Raynal Rocha , Passos-Soares Johelle de Santana
Published: July 2021

Leprosy reactions are immune processes that cause neural damage in individuals with leprosy. As periodontitis is an infectious disease related to its development, specific antibodies to periodontal pathogens must be evaluated. Therefore, the objective of this study was to standardize an immunoassay to measure IgA specific to P. gingivalis antigens in the saliva of individuals with leprosy. An ELISA checkerboard titration was performed. A validation test involving 53 individuals with leprosy, 24 with and 19 without periodontitis, was conducted and a ROC curve constructed to calculate sensitivity and specificity. The coefficient of the optical densities was 2.21 and 2.66 for P. gingivalis crude extract and HmuY, respectively. Sensitivity and specificity for the P. gingivalis crude extract were 66.7% and 73.7%, respectively, and for HmuY, were 62.5% and 52.6%, respectively. Specific recognition of P. gingivalis occurred predominantly in individuals with periodontitis, which validates the use of this test for studying periodontitis in individuals with leprosy.Trial registration: CAEE 64476117.3.0000.0049, 21/07/2017, retrospectively registered.
Thrombotic thrombocytopenic purpura associated with COVID-19 in a critically ill child: A Peruvian case report
Authors: Domínguez-Rojas Jesús Angel , Campano William , Tasayco Jaime , Siu-Lam Andrea , Ortega-Ocas Cesia , Atamari-Anahui Noé
Published: July 2021

Background
Acquired thrombotic thrombocytopenic purpura (TTP) is a rare disease. This pathology requires necessary resources for its diagnosis, especially in the context of the pandemic by the new SARS-CoV-2 coronavirus due to the lack of diagnostic tests and the variable response to plasma exchange in middle and low-income countries.
Case report:
We report a case of a 9-year-old Hispanic boy with SARS-CoV-2 (IgG) infection, with atypical presentation and multisystemic involvement, thrombotic microangiopathy, dermal manifestations, hematologic, kidney, and neurologic involvement. Post SARS-CoV-2 infection evolution, application of the PLASMIC score, and genetic study were performed. Ventilatory and hemodynamic support, corticotherapy, immunoglobulins, plasma exchange, renal replacement therapy, and monoclonal antibodies were given without favorable response.
Conclusions
TTP associated with SARS-CoV-2 is infrequent in the pediatric population. Necessary resources are needed to make the diagnosis and maintain the necessary support and management to avoid fatal outcomes.
HLA Complex P5 Upregulation Is Correlated With Poor Prognosis and Tumor Progression in Esophageal Squamous Cell Carcinoma
Authors: Wang Yaqin , Yu Zhijun , Shi Weidong , Shen Jian , Guan Yun , Ni Feng
Published: July 2021

Background: Esophageal squamous cell carcinoma (ESCC) is a deadly malignant tumor that threatens human health, especially in China. Long non-coding RNA (lncRNA) is widely expressed in eukaryotes and is closely associated with human disease progression. However, its role in ESCC remains incompletely understood. Here, we tested the role of HLA complex P5 (HCP5) in ESCC.Methods: Three GEO databases containing lncRNA expression data of ESCC and normal tissues were used to analyze the differentially expressed lncRNAs. The location of HCP5 was tested by qRT-PCR and FISH assays. The functional assay was detected by CCK-8, colony formation and Transwell assays. The HCP5/YTHDF1/HK2 axis was determined by RIP and RNA pull-down assays.Results: HCP5 was significantly overexpressed in ESCC tissues, which was further verified in our collected ESCC samples. The functional study suggested that HCP5 knockdown inhibited ESCC cell proliferation and invasion. Regarding the mechanism, HCP5 was able to directly interact with YTHDF1, a N6-methyladenosine (m6A) reader, enhancing the binding of YTHDF1 to m6A-modified HK2 mRNA, leading to increased HK2 stability, thereby promoting the Warburg effect (aerobic glycolysis) of ESCC cells. The nude mice model showed that knockdown of HCP5 in vivo remarkably reduced tumor size. Clinically, high HCP5 was positively correlated with larger tumor volume, higher TNM stage and lymph node metastasis. Moreover, ESCC patients with high HCP5 exerted shorter survival time than patients with low HCP5. Conclusion: These findings uncover the importance of HCP5 in human ESCC progression, the turbulence of HCP5/YTHDF1/HK2 axis may be responsible for ESCC carcinogenicity.
Modified Van der Pol-Helmohltz oscillator equation with exact harmonic solutions
Authors: O. AKPLOGAN Abdou R. , Damien ADJAI K. K. , Jean AKANDE , H. AVOSSEVOU Gabriel Y. , D. MONSIA Marc
Published: July 2021

We present in this paper an exceptional Lienard equation consisting of a modified Van der Pol-Helmholtz oscillator equation. The equation, a frequency-dependent damping oscillator, does not satisfy the usual existence theorems but, nevertheless, has an isochronous centre at the origin. We exhibit the exact and explicit general harmonic and isochronous solutions by using the first integral approach. The numerical results match very well analytical solutions.
NFκB mediates the anti-inflammatory actions of liraglutide and sitagliptin in experimentally model of colitis in mice
Authors: Nabeh Omnia Azmy , Attallah Magdy Ishaq , El-Gawhary Nawal El-Sayed , Mostafa Wael Mohamed
Published: July 2021

Inflammatory bowel disease (IBD) is a serious illness that negatively affects the human health due to its chronic course and serious complications. Glucagon like peptide (GLP-1) and its degradation enzyme inhibitor; dipeptidyl peptidase (DPP)-IV inhibitor, are used primarily as anti-diabetic drugs in patients with type 2 diabetes mellitus. However, current evidence suggests that both; GLP-1 (e.g. liraglutide) and the DPP-IV inhibitor (e.g. sitagliptin) may have a potential anti-inflammatory effect on various organ systems. This study was aimed to evaluate the potential of liraglutide and sitagliptin to improve colitis induced experimentally in mice using intra-rectal acetic acid, in comparison with sulfasalazine. Intra-rectal acetic acid was used to induce colitis in mice. The degree of inflammation was assessed using disease activity index, histopathological scoring, colonic length measurement as well as the colonic tissue expression of: the transcription factor; nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNFα), the oxidative stress marker; malondialdehyde and the inflammatory parameter; C-reactive protein. Moreover, random blood glucose was measured to ensure the safety of the tested drugs. Our results showed the positive impact of both liraglutide and sitagliptin on the assessed inflammatory parameters and their tolerability compared with sulfasalazine. Further clinical studies are needed to investigate the possibility to consider GLP axis as therapeutic adjuvants for IBD in the future.
Entropic Pressure of Cosmic Gas
Authors: Johnson Martin
Published: July 2021

Under the low-density conditions found in most of the Universe, the energy released by adiabatic expansion of its gases exceeds the amount required to offset the energy lost to decreased density. This excess is found locally as radial kinetic energy and more broadly manifest as a reduction in universal density over time.
Results from Hop Cultivar Trials in Mid-Atlantic United States
Authors: Rutto Laban K. , Xu Yixiang , Ren Shuxin , Scoggins Holly , Davis Jeanine
Published: July 2021

‘Hop’ (Humulus lupulus) cultivar trials were conducted at sites in three Virginia counties (Northampton, Chesterfield, and Madison) in response to demand by the craft beer industry for local ingredients. In 2016, a replicated study involving five cultivars (Cascade, Chinook, Newport, Nugget, and Zeus) was established on an 18-ft-tall trellis system at each site. Weather data influencing infectivity of downy mildew (Pseudoperonospora humuli) and powdery mildew (Podosphaera macularis), two economically important hop diseases, was collected, and to the extent possible, similar cultural practices were applied at each site. Climatic conditions favorable to P. humuli and P. macularis were present throughout the experimental period, and P. humuli infection was widespread at all sites starting from 2017. Among common pests, Japanese beetle (Popillia japonica) was the only one observed to cause significant damage. Unseasonably high rainfall in 2018 led to crop failure at all but the Northampton site, and harvesting was done at all sites only in 2017 and 2019. Yields (kilograms per hectare by weight) in 2017 were found to be ≥45% lower than second-year estimates for yards in the north and northwestern United States. Quality attributes (α and β acids; essential oil) for cones harvested from the Chesterfield site were comparable to published ranges for ‘Cascade’ in 2019, but lower for the other cultivars. More work is needed to identify or develop cultivars better suited to conditions in the southeastern United States. The influence of terroir on quality of commercial cultivars produced in the region should also be examined.
Genetic Diversity and Relationship of China’s Bergenia Germplasm Revealed by Intersimple Sequence Repeat Markers
Authors: Lv Xiuli , Guan Yuan , Wang Jian , Zhou Yanwei , Liu Qunlu , Yu Zequn
Published: July 2021

To reveal the genetic diversity and genetic relationships of China’s Bergenia germplasm, 28 Bergenia accessions from different regions in China were analyzed by 24 intersimple sequence repeat (ISSR) markers. The results showed that 318 sites were amplified in all germplasm, including 307 polymorphic sites, and the percentage of polymorphic sites was 96.54%. Cluster analysis showed that the 28 accessions were divided into three categories, with a similarity coefficient of 0.5475. Bergenia purpurascens was clustered into one category; B. scopulosa was clustered into one category; and B. tianquaninsis, B. emeiensis, B. stracheyi, and B. crassifolia were clustered into one category. The results of the cluster analysis indicated that the 28 accessions were not completely classified by origin. Using the ISSR marker technique to analyze the phylogenetic relationship of Bergenia germplasm is helpful for identifying valuable resources and providing a theoretical basis for the selection of breeding parents.
Ergodic edge modes in the 4D quantum Hall effect
Authors: Estienne Benoit , Oblak Blagoje , Stéphan Jean-Marie
Published: July 2021

The gapless modes on the edge of four-dimensional (4D) quantum Hall
droplets are known to be anisotropic: they only propagate in one
direction, foliating the 3D boundary into independent 1D conduction
channels. This foliation is extremely sensitive to the confining
potential and generically yields chaotic flows. Here we study the
quantum correlations and entanglement of such edge modes in 4D droplets
confined by harmonic traps, whose boundary is a squashed three-sphere.
Commensurable trapping frequencies lead to periodic trajectories of
electronic guiding centers; the corresponding edge modes propagate
independently along S^1S1
fibers, forming a bundle of 1D conformal field theories over a 2D base
space. By contrast, incommensurable frequencies produce quasi-periodic,
ergodic trajectories, each of which covers its invariant torus densely;
the corresponding correlation function of edge modes has fractal
features. This wealth of behaviors highlights the sharp differences
between 4D Hall droplets and their 2D peers; it also exhibits the
dependence of 4D edge modes on the choice of trap, suggesting the
existence of observable bifurcations due to droplet deformations.
Gênero, mulher, crime e violência
Authors: Silva André Luiz dos Santos , Meyer Dagmar Estermann , Riegel Roberta Plangg
Published: July 2021

O artigo discute e tensiona limites e possibilidades de articulação e “uso” das categorias mulher, gênero, crime e violência no desenho teórico-metodológico de uma pesquisa sobre as relações de gênero em escolas localizadas em regiões de alta incidência de denúncia de crimes contra mulheres. A seleção das escolas se apoiou num mapeamento das ocorrências registradas numa dada Delegacia Especializada de Atendimento à Mulher, processo que evidenciou a necessidade de identificar e problematizar o uso das categorias mulher, gênero, crime e violência, colocando em relevo as consideradas “endógenas” e “exógenas” às teorizações nas quais a pesquisa se inscreve. Esse processo demandou ainda a discussão do termo “violência de gênero” balizado, neste texto, pelos conceitos de de gênero, violência e poder. Entre aproximações e distanciamentos foi possível reconhecer os efeitos teóricos-metodológicos, de tais categorias, bem como os desafios éticos do uso de ferramentas que produzem geografias então nomeadas e reconhecidas como ‘violentas’.
Extracellular Vesicles Derived from Adipose-Derived Stem Cells Accelerate Diabetic Wound Healing by Suppressing the Expression of Matrix Metalloproteinase-9
Authors: Wang Jiang-wen , Zhu Yuan-zheng , Hu Xuan , Nie Jia-ying , Wang Zhao-hui , Wu Shu , Yi Yang-yan
Published: July 2021

Background:

The healing of diabetic wounds is poor due to a collagen deposition disorder.
Matrix metalloproteinase-9 (MMP-9) is closely related to collagen deposition in the process of tissue
repair. Many studies have demonstrated that extracellular vesicles derived from adipose-derived stem
cells (ADSC-EVs) promote diabetic wound healing by enhancing collagen deposition.

Objective:

In this study, we explored whether ADSC-EVs could downregulate the expression of
MMP-9 in diabetic wounds and promote wound healing by improving collagen deposition. The potential
effects of ADSC-EVs on MMP-9 and diabetic wound healing were tested both in vitro and in
vivo.

Methods:

We first evaluated the effect of ADSC-EVs on the proliferation and MMP-9 secretion of
HaCaT cells treated with advanced glycation end product-bovine serum albumin (AGE-BSA) using
CCK-8, western blot and MMP-9 enzyme-linked immunosorbent assay(ELISA). Next, the effects of
ADSC-EVs on healing, re-epithelialisation, collagen deposition, and MMP-9 concentration in diabetic
wound fluids were evaluated in an immunodeficient mouse model via MMP-9 ELISA and haematoxylin
and eosin, Masson’s trichrome, and immunofluorescence staining for MMP-9.

Results:

In vitro, ADSC-EVs promoted the proliferation and MMP-9 secretion of HaCaT cells. In
vivo, ADSC-EVs accelerated diabetic wound healing by improving re-epithelialisation and collagen
deposition and by inhibiting the expression of MMP-9.

Conclusion:

ADSC-EVs possess the potential of healing of diabetic wounds in a mouse model by inhibiting
downregulating MMP-9 and improving collagen deposition. Thus, ADSC-EVs are a promising
candidate for the treatment of diabetic wounds.
Lipotoxicity Disrupts Erythrocyte Function: A Perspective
Authors: Papadopoulos Charalampos , Tentes Ioannis , Anagnostopoulos Konstantinos
Published: July 2021

Background:

Lipid accumulation in the liver, skeletal and cardiac muscle, kidneys and
pancreas causes cell dysfunction, death and inflammation, a biological phenomenon named lipotoxicity.
Erythrocytes participate in the transport of lipids in the circulation, and their lipidome is
determined by exchange with blood components.

Objective:

The objective of this study is to summarize the current knowledge regarding the effect
of toxic lipid accumulation in erythrocytes.

Results:

Erythrocyte lipidome is altered in lipotoxic diseases, such as fatty liver disease, heart failure
and diabetes. In addition, ceramide, lysophosphatidylcholine, lysophosphatidic acid, palmitic
acid and free cholesterol induce erythrocyte malfunction.

Conclusion:

Erythrocytes are an additional cell target of lipotoxicity. Further exploration of the implicated
molecular mechanisms could lead to novel therapeutic targets for cardiometabolic and hematological
diseases.
Interplay between Heat Shock Proteins, Inflammation and Pain: A Promising
Therapeutic Approach
Authors: Forouzanfar Fatemeh , aminian Ahmad Reza
Published: July 2021

:

Heat Shock Proteins (HSPs) are important molecular chaperones that facilitate many
functions of the cells. They also play a pivotal role in cell survival, especially in the presence of
stressors, including nutritional deprivation, lack of oxygen, fever, alcohol, inflammation, oxidative
stress, heavy metals, as well as conditions that cause injury and necrosis. In the face of a painful stimulus
encounter, many factors could be associated with pain that may include nitric oxide, excitatory
amino acids, reactive oxygen species (ROS) formation, prostaglandins, and inflammatory cytokines.
One influential factor affecting pain reduction is the expression of HSPs that act as a ROS
scavenger, regulate the inflammatory cytokines, and reduce pain responses subsequently. Hence,
we assembled information on the painkilling attributes of HSPs. In this field of research, new
painkillers could be developed by targetting HSPs to alleviate pain and widen our grasp of pain in
pathological conditions and neurological diseases.
Screening of Phytochemicals from Curcuma Longa for their Inhibitory Activity
on SARS-CoV-2: An In-Silico Study
Authors: Negi Preeya , Das Lalita , Prakash Surya , Patil Vaishali M.
Published: July 2021

Introduction:

Natural products or phytochemicals have always been useful as effective
therapeutics providing the lead for rational drug discovery approaches in specific to anti-viral therapeutics.

Methods:

The ongoing pandemic caused by novel coronavirus has created a demand for effective
therapeutics. Thus, to achieve the primary objective to search for effective anti-viral therapeutics,
in silico screening of phytochemicals present in the extract of Curcuma longa (ex. Curcumin) has
been planned.

Results:

The present work involves the evaluation of ADME properties and molecular docking
studies.

Conclusion:

The application of rationalized drug discovery approaches to screen the diverse natural
resources will speed up the anti-COVID drug discovery efforts and benefit the global community.
Acceleration of Baylis-Hillman Reaction using Ionic Liquid Supported
Organocatalyst
Authors: Srivastava Vivek
Published: July 2021

Background:

Baylis-Hillman reaction requires cheap starting materials, easy reaction
protocol, and possibility to create the chiral center in the reaction product has increased the synthetic
efficacy of this reaction which also suffers from high catalyst loading, low reaction rate, and
poor yield.

Objective:

The extensive use of various functional or non-functional ionic liquids (ILs) with
organocatalyst acts not only as reaction medium but also as a support to anchor the catalysts to increase
the reaction rate of various organic transformations.

Methods:

In this manuscript, we have demonstrated the synthesis of quinuclidine-supported
trimethylamine-based functionalized ionic liquid as a catalyst for the Baylis-Hillman reaction.

Results:

We obtained the Baylis-Hillman adducts in good, isolated yield along with low catalyst
loading, short reaction time, wide substrate scope, easy product, and catalyst recycling. N-
((E,3S,4R)-5-benzylidene-tetrahydro-4-hydroxy-6-oxo-2H-pyran-3-yl) palmitamide was also successfully
synthesized using CATALYST-3 promoted Baylis-Hillman reaction.

Conclusion:

We successfully isolated the 25 types of Baylis-Hillman adducts using three different
quinuclidine-supported ammonium-based ionic liquids such as Et3AmQ][BF4] (CATALYST-1),
[Et3AmQ][PF6] (CATALYST-2), and [TMAAmEQ][NTf2](CATALYST-3) as new and efficient
catalysts. Generally, all the reactions demonstrated higher activity and gave good to high yield in
competition with various previously reported homogenous and heterogeneous catalytic systems.
Easy catalyst and product recovery followed by 6 times of catalysts recycling were the added advantages
of the prosed catalytic system. Tedious and highly active N-((E,3S,4R)-5-benzylidene-tetrahydro-
4-hydroxy-6-oxo-2H-pyran-3-yl) palmitamide derivative was also synthesized using CATALYST-
3 followed by Baylis-Hillman reaction.
Design and Effect of Escape Vent in a Trap on the Catch of Blue Swimming Crab (Portunus Pelagicus): A Preliminary Study
Authors: Rahman Muhammad Arif , Iranawati Feni , Sambah Abu Bakar
Published: July 2021

Blue Swimming Crab (Portunus pelagicus, BSC) is one of the Indonesian important fisheries commodities often captured by traps. Under Decree No. 56/2016, the Ministry of Marine Affairs and Fisheries managed the BSC, with the standard size of BSC is >10cm of Carapace Width (CW) or >60 g of Weight (W), and non-berried or carried eggs for female. This study aims to determine BSC's crawling pattern toward the trap, design an escape vent on the trap, and assess catch of BSC using vented trap and non-vented trap. The video footage was used to examine crawling pattern of 30 BSCs on the laboratory. The study also includes field experiment by deploying twenty traps (10 vented traps and 10 non-vented traps) on the sea. The study obtained two crawling patterns of BSC, crawling forward and sideways with the most BSC crawled sideways. Design of escape vent was 4.6 cm length x 2.6 cm height. The BSCs captured in the vented traps have >10cm of CW, while 14% of BSCs in the non-vented traps have <10 cm of CW. The use of escape vent did not affect the catch (weight) of BSC in the trap.
Progress and opportunities in modelling environmentally assisted cracking
Authors: Pañeda Emilio Martínez
Published: July 2021

Environmentally assisted cracking phenomena are widespread across the transport, defence, energy and construction sectors. However, predicting environmentally assisted fractures is a highly cross-disciplinary endeavour that requires resolving the multiple material-environment interactions taking place. In this manuscript, an overview is given of recent breakthroughs in the modelling of environmentally assisted cracking. The focus is on the opportunities created by two recent developments: phase field and multi-physics modelling. The possibilities enabled by the confluence of phase field methods and electro-chemo-mechanics modelling are discussed in the context of three environmental assisted cracking phenomena of particular engineering interest: hydrogen embrittlement, localised corrosion and corrosion fatigue. Mechanical processes such as deformation and fracture can be coupled with chemical phenomena like local reactions, ionic transport and hydrogen uptake and diffusion. Moreover, these can be combined with the prediction of an evolving interface, such as a growing pit or a crack, as dictated by a phase field variable that evolves based on thermodynamics and local kinetics. Suitable for both microstructural and continuum length scales, this new generation of simulation-based, multi-physics phase field models can open new modelling horizons and enable Virtual Testing in harmful environments.
Aplicaciones de la Derivada en economía y administración
Authors: Jara Riofrío Marco Antonio
Published: July 2021

La presente edición del texto, es un material didáctico de apoyo para el estudiante, en el proceso de enseñanza /aprendizaje de la asignatura Cálculo I, la cual se estudia como materia básica en el plan de estudio 2016 de la Universidad Tecnológica ECOTEC. En el texto se presentan, nuevo conocimiento y una aplicación práctica de la utilización de la derivada en la economía y administración empresarial. Por lo que esta asignatura, junto con Cálculo II (Cálculo Integral) brinda posibilidades formativas para el desarrollo de las competencias disciplinares de matemáticas en este nivel educativo.
Caracterización socioeconómica del Cantón Samborondón
Authors: Sorhegui Ortega Rafael Antonio , Granja Cañizares Nelsón Guillermo , Larrea Paredes Mónica Patricia , Márquez Sánchez Fidel , Macas Acosta Guido Omar , Villena Izurieta Nadia Priscila
Published: July 2021

Después de la postguerra, se comienza a prestar una atención priorizada a los problemas del Desarrollo Económico en la Ciencias Económica y se enfatiza en los temas regionales y en el desarrollo local. Desde finales de los años 70, cuando dejó de ser operativo el modelo de desarrollo cuyo eje principal consistía en atraer y promover la inversión exógena para las regiones, en correspondencia con las transformaciones que tienen lugar la economía mundial emerge un nuevo paradigma de desarrollo que le da un nuevo rol al territorio y que valoriza el potencial endógeno, el llamado “desarrollo endógeno”. En esa misma época comienza la preocupación de la problemática ambiental relacionada con el crecimiento económico y se establece la interconexión y la interdependencia entre el crecimiento y desarrollo económico con lo ambiental que se sintetiza en el concepto de Desarrollo Económico Sostenible. Para Ecuador, la problemática del desarrollo económico sostenible es particularmente importante en el estudio de la dimensión territorial, mediante el desarrollo local. En tal sentido, se trata de un proceso sostenible, sistemático, equitativo y respetuoso del medio ambiente que tiene por objeto generar y fortalecer sus dinámicas económicas, sociales y culturales, así como la articulación entre ellas, y dar respuesta al desarrollo socioeconómico de la comunidad. Debido a lo antes mencionado, en este libro se estructura en tres capítulos, donde desde la perspectiva de las Ciencias Económicas se valora el desarrollo socioeconómico territorial, acorde a la dinámica del mundo actual en general y del Ecuador en particular, como resultado del proceso desarrollado de un Proyecto de Investigación liderado por docentes de la Universidad Tecnológica ECOTEC, quienes son los autores respectivamente, de cada uno de estos capítulos, quienes en colaboración con sus estudiantes pudieron establecer puntos de encuentros sobre esta experiencia asociada con el desarrollo sostenible específicame
Desarrollo sostenible y medio ambiente
Authors: Vergara Romero Arnaldo , Rojas Dávila Muman Andrés , Castro Reyes Daniel Eduardo , Márquez Sánchez Fidel , Llaque Lino Juan Luis , Granja Cañizares Nelson Guillermo , Morán Quijije Eduardo Erasmo , Sorhegui Ortega Rafael Antonio , Guzhñay Hidalgo Raúl Andrés , Pozo Estupiñan César Augusto
Published: July 2021

Las concepciones teórica-metodológica de las diferentes corrientes de pensamiento establecen múltiples interpretaciones para un mismo objeto de estudio, principalmente, cuando se trata de analizar causas, motivos, interrelaciones, consecuencias y tendencias de fenómenos económicossociales; aunque se muestre una relativa coincidencia en lo que se refiere a la descripción del fenómeno, características y rasgos más sobresalientes. La conceptualización del desarrollo describe en general el proceso de mejorar el bienestar y la calidad de la vida, que entraña el cambio progresivo de la condición socioeconómica y política. El desarrollo no solo se refiere al crecimiento económico, sino también a cambios fundamentales en la estructura económica y al desarrollo social, ambiental y humano. En ese contexto, el desarrollo debe representar teóricamente mayores oportunidades de elección y capacidad para aprovecharlas.
La gestión del proceso de profesionalización docente en la Universidad Tecnológica Ecotec
Authors: Alfonso Caveda Duniesky , Calderón Farfán Elba Elizabeth , Muñoz Verdezoto Patricia Jacqueline , Marrero Sánchez Odalys , González Rodríguez Nadia Aurora
Published: July 2021

La formación profesional contemporánea está supeditada a los niveles de integración de la universidad al medio social y cómo este proceso brinda soluciones acertadas a los problemas del entorno. De tal forma, la profesionalización universitaria requiere procesos sustantivos adecuados que actúen como ejes transversales a las propuestas curriculares en la formación de los profesionales universitarios. Su adecuada integración es premisa indispensable para lograr los niveles de pertinencia que demandan los contextos de actuación formación contemporáneos (Alfonso Caveda y Jaya, 2016). La UNESCO en su Informe de seguimiento de la educación en el mundo, 2019: Migración, desplazamiento y educación: construyendo puentes, no muros, señala: No basta con proporcionar educación únicamente: el entorno escolar debe adaptarse y responder a las necesidades específicas… Un personal docente bien capacitado es fundamental para integrar a los alumnos…Es asimismo vital contar con programas de estudios bien ideados, que promuevan la diversidad, proporcionen las competencias necesarias… (UNESCO, 2018).
La Investigación Científica en el desarrollo de competencias en la Educación Superior
Authors: Aguirre Jiménez Silvia , Calderón Cisneros Juan Tarquino , Sorhegui Ortega Rafael , Alcívar Trejo Carlos , St. Omer Navarro Vilma , Alfonso Caveda Duniesky , Ortìz Chimbo Karla Maribel
Published: July 2021

La importancia de la investigación científica en los docentes y la educación, siempre han estados ligados basados en los procesos metodológicos de la Formación Basada en Competencias, en la educación superior se enmarcan en la formación integral. Esto exige procesos de transformación curricular basados en el direccionamiento estratégico en la organización curricular por módulos y proyectos formativos, y la planeación del aprendizaje por problemas donde los métodos y técnicas de investigación científica son inseparables de la ciencia. Ya que de acorde a la época que vivimos, la ciencia y tecnologías representan ser las herramientas fundamentales dentro de los procesos de aprendizajes-cognitivos y actitudinales de cada ser, sin embargo, se debe llegar a un límite superior el cual nos permita rebasar el racionalismo científico y la búsqueda de una ciencia con conciencia prevaleciendo la esencia del ser humano y su raciocinio, en la optimización de en una educación de calidad y calidez. Es por tales motivos que en la actualidad las reformas de la educación de los países latinoamericanos optaron por concentrar sus esfuerzos en la capacitación de maestros, a veces en un contexto de políticas, estrategias y programas de educación continua. Pese a todas las acciones ejecutadas, no han demostrado la mejora del rendimiento de conformidad con el aprendizaje de los estudiantes, y menos los cambios esperados en la calidad educativa.
Administración Educativa: Los Procesos De Gestión En La Eficacia De La Gerencia Educativa Universitaria
Authors: Passailaigue Baquerizo Roberto M.
Published: July 2021

La obra “Administración Educativa. Los procesos de gestión en la eficacia educativa universitaria” es el producto de la investigación en el área de la administración educativa, del profesor Roberto Passailaigue Baquerizo, resultado de un “caminar” suave y fuerte a la vez. Él ha transitado por mucho tiempo en los Sistemas Nacionales de Educación y de Educación Superior del Ecuador, en sus diferentes niveles, instituciones y circunstancias, y ese transitar le ha dado la solvencia académica y experiencia necesaria para poder opinar, con autoridad, sobre la eficacia educativa.
Lessons From a Rapid Project Management Exercise in the Time of Pandemic: Methodology for a Global COVID-19 VIRUS Registry Database
Authors: Turek Janice R , Bansal Vikas , Tekin Aysun , Singh Shuchita , Deo Neha , Sharma Mayank , Bogojevic Marija , Qamar Shahraz , Singh Romil , Kumar Vishakha , Kashyap Rahul
Published: July 2021

Background

The rapid emergence of the COVID-19 pandemic globally collapsed health care organizations worldwide. Incomplete knowledge of best practices, progression of disease, and its impact could result in fallible care. Data on symptoms and advancement of the SARS-CoV-2 virus leading to critical care admission have not been captured or communicated well between international organizations experiencing the same impact from the virus. This led to the expedited need for establishing international communication and data collection on the critical care patients admitted with COVID-19.

Objective

Developing a global registry to collect patient data in the critical care setting was imperative with the goal of analyzing and ameliorating outcomes.

Methods

A prospective, observational global registry database was put together to record extensive deidentified clinical information for patients hospitalized with COVID-19.

Results

Project management was crucial for prompt implementation of the registry for synchronization, improving efficiency, increasing innovation, and fostering global collaboration for valuable data collection. The Society of Critical Care Medicine Discovery VIRUS (Viral Infection and Respiratory Illness Universal Study): COVID-19 Registry would compile data for crucial longitudinal outcomes for disease, treatment, and research. The agile project management approach expedited establishing the registry in 15 days and submission of institutional review board agreement for 250 participating sites. There has been enrollment of sites every month with a total of 306 sites from 28 countries and 64,114 patients enrolled (as of June 7, 2021).

Conclusions

This protocol addresses project management lessons in a time of crises which can be a precept for rapid project management for a large-scale health care data registry. We aim to discuss the approach and methodology for establishing the registry, the challenges faced, and the factors contributing to successful outcomes.

Trial Registration

ClinicalTrials.gov NCT04323787; https://clinicaltrials.gov/ct2/show/NCT04323787
Predicting Antituberculosis Drug–Induced Liver Injury Using an Interpretable Machine Learning Method: Model Development and Validation Study
Authors: Zhong Tao , Zhuang Zian , Dong Xiaoli , Wong Ka Hing , Wong Wing Tak , Wang Jian , He Daihai , Liu Shengyuan
Published: July 2021

Background

Tuberculosis (TB) is a pandemic, being one of the top 10 causes of death and the main cause of death from a single source of infection. Drug-induced liver injury (DILI) is the most common and serious side effect during the treatment of TB.

Objective

We aim to predict the status of liver injury in patients with TB at the clinical treatment stage.

Methods

We designed an interpretable prediction model based on the XGBoost algorithm and identified the most robust and meaningful predictors of the risk of TB-DILI on the basis of clinical data extracted from the Hospital Information System of Shenzhen Nanshan Center for Chronic Disease Control from 2014 to 2019.

Results

In total, 757 patients were included, and 287 (38%) had developed TB-DILI. Based on values of relative importance and area under the receiver operating characteristic curve, machine learning tools selected patients’ most recent alanine transaminase levels, average rate of change of patients’ last 2 measures of alanine transaminase levels, cumulative dose of pyrazinamide, and cumulative dose of ethambutol as the best predictors for assessing the risk of TB-DILI. In the validation data set, the model had a precision of 90%, recall of 74%, classification accuracy of 76%, and balanced error rate of 77% in predicting cases of TB-DILI. The area under the receiver operating characteristic curve score upon 10-fold cross-validation was 0.912 (95% CI 0.890-0.935). In addition, the model provided warnings of high risk for patients in advance of DILI onset for a median of 15 (IQR 7.3-27.5) days.

Conclusions

Our model shows high accuracy and interpretability in predicting cases of TB-DILI, which can provide useful information to clinicians to adjust the medication regimen and avoid more serious liver injury in patients.
Evaluating Quality, Usability, Evidence-Based Content, and Gamification Features in Mobile Learning Apps Designed to Teach Children Basic Life Support: Systematic Search in App Stores and Content Analysis (Preprint)
Authors: Fijačko Nino , Masterson Creber Ruth , Gosak Lucija , Štiglic Gregor , Egan Dominic , Chaka Brian , Debeljak Nika , Strnad Matej , Skok Pavel
Published: July 2021

BACKGROUND

Globally, 3.7 million people die of sudden cardiac death annually. Following the World Health Organization endorsement of the Kids Save Lives statements, initiatives to train school-age children in basic life support (BLS) have been widespread. Mobile phone apps, combined with gamification, represent an opportunity for including mobile learning (m-learning) in teaching schoolchildren BLS as an additional teaching method; however, the quality of these apps is questionable.

OBJECTIVE

This study aims to systematically evaluate the quality, usability, evidence-based content, and gamification features (GFs) of commercially available m-learning apps for teaching guideline-directed BLS knowledge and skills to school-aged children.

METHODS

We searched the Google Play Store and Apple iOS App Store using multiple terms (eg, cardiopulmonary resuscitation [CPR] or BLS). Apps meeting the inclusion criteria were evaluated by 15 emergency health care professionals using the user version of the Mobile Application Rating Scale and System Usability Scale. We modified a five-finger mnemonic for teaching schoolchildren BLS and reviewed the apps’ BLS content using standardized criteria based on three CPR guidelines. GFs in the apps were evaluated using a gamification taxonomy.

RESULTS

Of the 1207 potentially relevant apps, only 6 (0.49%) met the inclusion criteria. Most apps were excluded because the content was not related to teaching schoolchildren BLS. The mean total scores for the user version of the Mobile Application Rating Scale and System Usability Scale score were 3.2/5 points (95% CI 3.0-3.4) and 47.1/100 points (95% CI 42.1-52.1), respectively. Half of the apps taught hands-only CPR, whereas the other half also included ventilation. All the apps indicated when to start chest compressions, and only 1 app taught BLS using an automated external defibrillator. Gamification was well integrated into the m-learning apps for teaching schoolchildren BLS, whereas the personal and fictional, educational, and performance gamification groups represented most GFs.

CONCLUSIONS

Improving the quality and usability of BLS content in apps and combining them with GFs can offer educators novel m-learning tools to teach schoolchildren BLS skills.
The “poisonous water” (mê rʾōš) in Jer 8:14 and the “bewitched water” (mê kaššāpūti) in Maqlû i 103-104: witchcraft in the book of Jeremiah
Authors: Conti Cristiana
Published: July 2021

Some scholars consider the biblical phrase mê rʾōš (“poisonous water”) a metaphor for the venom of a snake, others interpret it as a poisonous substance produced by pressing herbs and still, others believe it to be a metaphor for the destruction of the people Israel and their land. In the book of Jeremiah in particular, the phrase mê rʾōš appears three times (8:14, 9:15, and 23:15) and in all cases, it appears in execratory contexts. Numerous studies have put this phrase in relation to the trial ordeal in Numbers 5:11-31, and have therefore recognized its execratory nature, yet, to my knowledge, no one has ever studied it against the background of the Neo-Assyrian magical tradition. Accordingly, the expression “poisonous water” may have magical nuances attached to it. For example, the ancient Mesopotamians believed that curses could be passed to the victim by means of food or drink. In this analysis, I argue that the expression mê rʾōš may have the function that the Akkadian phrase mê kaššāpūti (“bewitched water”) has in Assyrian anti-witchcraft rituals where the administration of a poisonous drink symbolized the nullification of a curse as it was believed that the bewitched potion given to the evildoer returned to him the evil he had intended for his victim. In my talk, I will analyze the theme of the transfer of the curse through liquids and food in select Assyrian literature. I will then show how the book of Jeremiah redeployed this Assyrian theme to articulate its theological offensive against the harmful effects of the oracular utterances of illegitimate Prophets.
A SYSTEMIC REVIEW ON NOVEL TECHNIQUES USED IN THE DETERMINATION OF NEUROPEPTIDE THROUGH THE ANALYTICAL TECHNIQUES
Authors: Choudhary Nilesh C.
Published: July 2021

Neuropeptides are a group of signaling molecules which are located in central nervous system. They control essential physiological function in animals like cardiovascular activity, energy, reproduction, growth, homeostasis, behavior, and stress response. Neuropeptides are the endogenous peptides they act as a neurotransmitter, neuromodulator and hormones. The detection process of neuropeptides is challenging due to their cleavage by peptidases and undergoes posttranslational modification. The in vivo isolation of neuropeptides occurs at very small concentrations as a significance of the efforts made to establish new neuropeptide detection techniques. Here, we examine these view points and the related strategies, and new techniques concentrating on advancements that have exhibited potential in propelling the field lately.
PHARMACOKINETIC DETERMINATION OF METHYLPREDNISOLONE IN INDIAN HEALTHY VOLUNTEERS BY LC-MS/MS
Authors: Das Dibya
Published: July 2021

Methylprednisolone is a synthetic glucocorticoid. It relieves inflammation and uses to treat thyroid, colitis, allergies, asthma, and many more. This study aims to develop a bio-analytical method for measuring methylprednisolone in human plasma, accurate, sensitive, rapid, precise and simple. In this study, Propranolol used as an Internal Standard (IS). Liquid Chromatography with tandem mass spectrometry (LC-MS/MS) instrument was used to identify and quantify the drug. Gradient conditions were used to establish the method; with a flow rate of 0.5 ml/min, we used 0.1 % formic acid in Milli-Q water and 0.1 % formic acid in methanol as mobile phases. A C18 Phenomenex Kinetex (50x3 mm, 5µ) column was used to isolate the analyte and the IS. The total chromatographic run time 7.0 min. The extraction of analyte and IS from plasma is done by a simple protein precipitation technique. The method was very selective and sensitive. Lower limit of quantification was 12.50 ng/ml. Linearity range between 12.50 ng/ml - 800ng/ml. The precision and accuracy results from 5 validation batches at five different concentration levels were well within acceptable ranges. The analyte was stable under different stability conditions. The developed method was found reproducible and very simple. The Retention Time of the analyte and IS was 3.53 min and 3.24 min, respectively. The methodology was validated in accordance with EMEA and USFDA regulations. The particular study has been carried out expertly on the pharmacokinetic study and BA/BE study in healthy human male volunteers. No Serious Adverse Events were noted in the clinical phase.
Mathematical modeling of stress waves under concentrated vertical action in the form of a triangular pulse: Lamb’s problem
Authors: Musayev Vyacheslav K.
Published: July 2021

The aim of the work. The problem of numerical simulation of longitudinal, transverse and surface waves on the free surface of an elastic half-plane is considered. Methods. To solve the non-stationary dynamic problem of elasticity theory with initial and boundary conditions, the finite element method in displacements was used. Using the finite element method in displacements, a linear problem with initial and boundary conditions was led to a linear Cauchy problem. A quasiregular approach to solving a system of second-order linear ordinary differential equations in displacements with initial conditions and to approximating the area under study is proposed. The method is based on the schemes: point, line and plane. The study area is divided by spatial variables into triangular and rectangular finite elements of the first order. According to the time variable, the study area is divided into linear end elements with two nodal points. The Fortran-90 algorithmic language was used in the development of the software package. Results. Some information is given about numerical modeling of elastic stress waves in an elastic half-plane with a concentrated wave action in the form of a Delta function. The estimated area under study has 12 008 001 nodal points. A system of equations consisting of 48 032 004 unknowns is solved. The change of elastic contour stress on the free surface of the half-plane at different points is shown. The amplitude of Rayleigh surface waves is significantly greater than the amplitudes of longitudinal, transverse, and other waves with a concentrated vertical action in the form of a triangular pulse on the surface of an elastic half-plane. After surface Rayleigh waves, a dynamic process is observed in the form of standing waves.
Joint operation of the cellular structure as a system “frame - filling ground - base”
Authors: Zimnyukov Vladimir A. , Zborovskaya Marina I.
Published: July 2021

Relevance. The experience of constructed cellular structures and the results of computational and model studies carried out in our country and abroad to assess the joint work of the complicated complex cellular frame - soil backfill of cells - foundation indicates the sufficient reliability of such hydraulic structures. The main difficulty in the design of cellular structures is to reproduce the volumetric work of the complex cellular frame - backfill soil - foundation soil to identify structural reserves. Objectives. To study, through laboratory studies, the interaction of the frame and backfill of the cell and the base at different soil moisture, taking into account such factors as the granulometric composition of the backfill soil, the role of the surface tension of moisture contained in the soil, the geometric parameters of the structure itself and a number of other factors. Methods. Experimental studies on the model of the operation of a cellular structure without a bottom on a non-rocky (sandy) foundation for stability, subject to the similarity criteria, as well as studies of cells with different geometry and sizes with changes in moisture and particle size distribution of the soil of the cells. Results. Based on the results of model studies, a dependence is proposed to take into account the effect of surface tension forces, considering the hydraulic radius of the cell cross-section, wetted perimeter, cross-sectional area of the cell, etc. The interaction of the cellular structure with the base is also explored, taking into account the above parameters. The results of laboratory studies on considering the interaction of the frame and backfill of the cell soil at different moisture content of the aggregate, taking into account the granulometric composition of the backfill soil surface tension of moisture contained in the soil, geometric parameters of the structure itself and a number of other factors.