bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prevalence of Arcobacteraceae in Aquatic Environments: A Systematic Review and Meta-Analysis
Authors: Venâncio Igor , Luís Ângelo , Domingues Fernanda , Oleastro Mónica , Pereira Luísa , Ferreira Susana
Published: February 2022

Members of the family Arcobacteraceae are distributed widely in aquatic environments, and some of its species have been associated with human and animal illness. However, information about the diversity and distribution of Arcobacteraceae in different water bodies is still limited. In order to better characterize the health risk posed by members in the family Arcobacteraceae, a systematic review and meta-analysis-based method was used to investigate the prevalence of Arcobacteraceae species in aquatic environments based on available data published worldwide. The database search was performed using related keywords and considering studies up to February 2021. The pooled prevalence in aquatic environments was 69.2%, ranging from 0.6 to 99.9%. These bacteria have a wide geographical distribution, being found in diverse aquatic environments with the highest prevalence found in raw sewage and wastewater treatment plants (WWTP), followed by seawater, surface water, ground water, processing water from food processing plants and water for human consumption. Assessing the effectiveness of treatments in WWTP in eliminating this contamination, it was found that the wastewater treatment may not be efficient in the removal of Arcobacteraceae. Among the analyzed Arcobacteraceae species, Al. butzleri was the most frequently found species. These results highlight the high prevalence and distribution of Arcobacteraceae in different aquatic environments, suggesting a risk to human health. Further, it exposes the importance of identifying and managing the sources of contamination and taking preventive actions to reduce the burden of members of the Arcobacteraceae family.
Ligands and Beyond: Mechanosensitive Adhesion GPCRs
Authors: Lin Hsi-Hsien , Ng Kwai-Fong , Chen Tse-Ching , Tseng Wen-Yi
Published: February 2022

Cells respond to diverse types of mechanical stimuli using a wide range of plasma membrane-associated mechanosensitive receptors to convert extracellular mechanical cues into intracellular signaling. G protein-coupled receptors (GPCRs) represent the largest cell surface protein superfamily that function as versatile sensors for a broad spectrum of bio/chemical messages. In recent years, accumulating evidence has shown that GPCRs can also engage in mechano-transduction. According to the GRAFS classification system of GPCRs, adhesion GPCRs (aGPCRs) constitute the second largest GPCR subfamily with a unique modular protein architecture and post-translational modification that are well adapted for mechanosensory functions. Here, we present a critical review of current evidence on mechanosensitive aGPCRs.
Synergistic Adverse Effects of Azithromycin and Hydroxychloroquine on Human Cardiomyocytes at a Clinically Relevant Treatment Duration
Authors: Li Wener , Luo Xiaojing , Poetsch Mareike S. , Oertel Reinhard , Nichani Kapil , Schneider Martin , Strano Anna , Hasse Marcel , Steiner Robert-Patrick , Cyganek Lukas , Hettwer Karina , Uhlig Steffen , Simon Kirsten , Guan Kaomei , Schubert Mario
Published: February 2022

Adverse effects of drug combinations and their underlying mechanisms are highly relevant for safety evaluation, but often not fully studied. Hydroxychloroquine (HCQ) and azithromycin (AZM) were used as a combination therapy in the treatment of COVID-19 patients at the beginning of the pandemic, leading to higher complication rates in comparison to respective monotherapies. Here, we used human-induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) to systematically investigate the effects of HCQ, AZM, and their combination on the structure and functionality of cardiomyocytes, and to better understand the underlying mechanisms. Our results demonstrate synergistic adverse effects of AZM and HCQ on electrophysiological and contractile function of iPSC-CMs. HCQ-induced prolongation of field potential duration (FPDc) was gradually increased during 7-day treatment period and was strongly enhanced by combination with AZM, although AZM alone slightly shortened FPDc in iPSC-CMs. Combined treatment with AZM and HCQ leads to higher cardiotoxicity, more severe structural disarrangement, more pronounced contractile dysfunctions, and more elevated conduction velocity, compared to respective monotreatments. Mechanistic insights underlying the synergistic effects of AZM and HCQ on iPSC-CM functionality are provided based on increased cellular accumulation of HCQ and AZM as well as increased Cx43- and Nav1.5-protein levels.
2021 FDA TIDES (Peptides and Oligonucleotides) Harvest
Authors: Al Shaer Danah , Al Musaimi Othman , Albericio Fernando , de la Torre Beatriz G.
Published: February 2022

From the medical, pharmaceutical, and social perspectives, 2021 has been a year dominated by the COVID-19 pandemic. However, despite this global health crisis, the pharmaceutical industry has continued its endeavors, and 2021 could be considered an excellent year in terms of the drugs accepted by the US Food and Drug Administration (FDA). Thus, during this year, the FDA has approved 50 novel drugs, of which 36 are new chemical entities and 14 biologics. It has also authorized 10 TIDES (8 peptides, 2 oligonucleotides), in addition to 2 antibody-drug conjugates (ADCs) whose structures contain peptides. Thus, TIDES have accounted for about 24% of the approvals in the various drug categories. Importantly, this percentage has surpassed the figure in 2020 (10%), thus reflecting the remarkable success of TIDES. In this review, the approved TIDE-based drugs are analyzed on the basis of their chemical structure, medical target, mode of action, administration route, and adverse effects.
The In Vivo Quantitative Assessment of the Effectiveness of Low-Dose Photodynamic Therapy on Wound Healing Using Optical Coherence Tomography
Authors: Zuhayri Hala , Nikolaev Viktor V. , Lepekhina Tatiana B. , Sandykova Ekaterina A. , Krivova Natalya A. , Kistenev Yury V.
Published: February 2022

The effect of low-dose photodynamic therapy on in vivo wound healing was investigated using optical coherence tomography. This work aims to develop an approach to quantitative assessment of the wound’s state during wound healing including the effect of low-dose photodynamic therapy using topical application of two different photosensitizers, 5-aminolevulinic acid and methylene blue, and two laser doses of 1 J/cm2 and 4 J/cm2. It was concluded that the laser dose of 4 J/cm2 was better compared to 1 J/cm2 and allowed the wound healing process to accelerate.
Effects of Ultramicronized N-Palmitoylethanolamine Supplementation on Tramadol and Oxycodone Analgesia and Tolerance Prevention
Authors: Micheli Laura , Lucarini Elena , Toti Alessandra , Ferrara Valentina , Ciampi Clara , Parisio Carmen , Bartolucci Gianluca , Di Cesare Mannelli Lorenzo , Ghelardini Carla
Published: February 2022

Chronic pain management requires increasing doses of opioids, the milestone of painkillers, which may result in the onset of tolerance with exacerbated side effects. Maintaining stable analgesia with low doses of opioids is thus imperative. N-palmitoylethanolamine (PEA) is an endogenous lipid compound endowed with pain-relieving as well as anti-inflammatory properties. The ultramicronized formulation of PEA was recently demonstrated to be able to modulate morphine’s effects, delaying tolerance and improving efficacy. To evaluate the possible application to other opioids, in this study, we analysed the capacity of ultramicronized PEA to regulate analgesia and tolerance induced by oxycodone and tramadol. Pre-emptive and continuative treatment with ultramicronized PEA (30 mg kg−1, daily, per os) delayed the onset of opioid tolerance and enhanced opioid analgesia when it was acutely administered in association with tramadol (20 mg kg−1, daily, subcutaneously) or oxycodone (0.5 mg kg−1, daily, subcutaneously). Moreover, PEA exerted antinociceptive effects on tolerant rats, suggesting the use of PEA together with opioids for stable, long-lasting analgesia. To that purpose, the oxycodone dose needed to be increased from 0.3 mg kg−1 (day 1) up to 1 mg kg−1 (day 31) in the oxycodone + vehicle group; the tramadol dose was progressively enhanced from 15 mg kg−1 to 50 mg kg−1 in 31 days in the tramadol + vehicle group. Acute oral co-treatment with PEA (120 mg kg−1) achieved the same analgesia without increasing the dose of both opioids. The behavioural effects of PEA on opioid chronic treatment paralleled a decrease in astrocyte activation in the dorsal horn of the spinal cord (a marker of the development of opioid tolerance) and with a modulation of mRNA expression of IL-6 and serpin-A3. In conclusion, pre- and co-administration of ultramicronized PEA delayed the development of tramadol tolerance, potentiating either oxycodone or tramadol analgesia and allowing a long-lasting analgesic effect with a low opioid dose regimen. The use of PEA is suggested for clinical purposes to support the opioid-based management of persistent pain.
Human Bone Marrow Mesenchymal Stromal/Stem Cells Regulate the Proinflammatory Response of Monocytes and Myeloid Dendritic Cells from Patients with Rheumatoid Arthritis
Authors: Laranjeira Paula , Pedrosa Mónia , Duarte Cátia , Pedreiro Susana , Antunes Brígida , Ribeiro Tânia , dos Santos Francisco , Martinho António , Fardilha Margarida , Domingues M. Rosário , Abecasis Manuel , Pereira da Silva José António , Paiva Artur
Published: February 2022

Rheumatoid arthritis (RA) is a disabling autoimmune disease whose treatment is ineffective for one-third of patients. Thus, the immunomodulatory potential of mesenchymal stromal/stem cells (MSCs) makes MSC-based therapy a promising approach to RA. This study aimed to explore the immunomodulatory action of human bone marrow (BM)-MSCs on myeloid dendritic cells (mDCs) and monocytes, especially on cytokines/chemokines involved in RA physiopathology. For that, LPS plus IFNγ-stimulated peripheral blood mononuclear cells from RA patients (n = 12) and healthy individuals (n = 6) were co-cultured with allogeneic BM-MSCs. TNF-α, CD83, CCR7 and MIP-1β protein levels were assessed in mDCs, classical, intermediate, and non-classical monocytes. mRNA expression of other cytokines/chemokines was also evaluated. BM-MSCs effectively reduced TNF-α, CD83, CCR7 and MIP-1β protein levels in mDCs and all monocyte subsets, in RA patients. The inhibition of TNF-α production was mainly achieved by the reduction of the percentage of cellsproducing this cytokine. BM-MSCs exhibited a remarkable suppressive action over antigen-presenting cells from RA patients, potentially affecting their ability to stimulate the immune adaptive response at different levels, by hampering their migration to the lymph node and the production of proinflammatory cytokines and chemokines. Accordingly, MSC-based therapies can be a valuable approach for RA treatment, especially for non-responder patients.
Ganciclovir Pharmacokinetics and Individualized Dosing Based on Covariate in Lung Transplant Recipients
Authors: Dvořáčková Eliška , Šíma Martin , Petrus Jakub , Klapková Eva , Hubáček Petr , Pozniak Jiří , Havlín Jan , Lischke Robert , Slanař Ondřej
Published: February 2022

The aim of this prospective study was to evaluate the pharmacokinetics of ganciclovir in lung transplant recipients, to explore its covariates, and to propose an individualized dosing regimen. Ganciclovir was administered according to the protocol in a standardized intravenous dose of 5 mg/kg twice daily. Serum ganciclovir concentrations were monitored as a trough and at 3 and 5 h after dosing. Individual ganciclovir pharmacokinetic parameters were calculated in a two-compartmental pharmacokinetic model, while regression models were used to explore the covariates. Optimal loading and maintenance doses were calculated for each patient. In lung transplant recipients (n = 40), the median (IQR) ganciclovir total volume of distribution and clearance values were 0.65 (0.52–0.73) L/kg and 0.088 (0.059–0.118) L/h/kg, respectively. We observed medium-to-high inter-individual but negligible intra-individual variability in ganciclovir pharmacokinetics. The volume of distribution of ganciclovir was best predicted by height, while clearance was predicted by glomerular filtration rate. Bodyweight-normalized clearance was significantly higher in patients with cystic fibrosis, while distribution half-life was reduced in this subgroup. On the basis of the observed relationships, practical nomograms for individualized ganciclovir dosing were proposed. The dosing of ganciclovir in patients with cystic fibrosis requires special caution, as their daily maintenance dose should be increased by approximately 50%.
Stochastic Ultralow-Frequency Oscillations of the Luminescence Intensity from the Surface of a Polymer Membrane Swelling in Aqueous Salt Solutions
Authors: Bunkin Nikolai F. , Bolotskova Polina N. , Bondarchuk Elena V. , Gryaznov Valery G. , Kozlov Valeriy A. , Okuneva Maria A. , Ovchinnikov Oleg V. , Smoliy Oleg P. , Turkanov Igor F. , Galkina Catherine A. , Dmitriev Alexandr S. , Seliverstov Alexandr F.
Published: February 2022

Photoluminescence from the surface of a Nafion polymer membrane upon swelling in isotonic aqueous solutions and Milli-Q water has been studied. Liquid samples were preliminarily processed by electric pulses with a duration of 1 μs and an amplitude of 0.1 V using an antenna in the form of a flat capacitor; experiments on photoluminescent spectroscopy were carried out 20 min after this treatment. A typical dependence of the luminescence intensity, I, on the swelling time, t, obeys an exponentially decaying function. The characteristic decay time of these functions and the stationary level of luminescence intensity depend on the repetition rate of electrical pulses, and the obtained dependences are well reproduced. It transpired that, at certain pulse repetition rates, the dependence, I(t), is a random function, and there is no reproducibility. Stochastic effects are associated with a random external force of an electromagnetic nature that acts on a polymer membrane during swelling. The source of this random force, in our opinion, is low-frequency pulsations of neutron stars or white dwarfs.
Chitosan-Based Therapeutic Systems for Superficial Candidiasis Treatment. Synergetic Activity of Nystatin and Propolis
Authors: Humelnicu Andra-Cristina , Samoilă Petrișor , Cojocaru Corneliu , Dumitriu Raluca , Bostănaru Andra-Cristina , Mareș Mihai , Harabagiu Valeria , Simionescu Bogdan C.
Published: February 2022

The paper deals with new approaches to chitosan (CS)-based antifungal therapeutic formulations designed to fulfill the requirements of specific applications. Gel-like formulations were prepared by mixing CS dissolved in aqueous lactic acid (LA) solution with nystatin (NYS) powder and/or propolis (PRO) aqueous solution dispersed in glycerin, followed by water evaporation to yield flexible mesoporous (pore widths of 2–4 nm) films of high specific surfaces between 1 × 103 and 1.7 × 103 m2/g. Morphological evaluation of the antifungal films showed uniform dispersion and downsizing of NYS crystallites (with initial sizes up to 50 μm). Their mechanical properties were found to be close to those of soft tissues (Young’s modulus values between 0.044–0.025 MPa). The films presented hydration capacities in physiological condition depending on their composition, i.e., higher for NYS-charged (628%), as compared with PRO loaded films (118–129%). All NYS charged films presented a quick release for the first 10 min followed by a progressive increase of the release efficiency at 48.6%, for the samples containing NYS alone and decreasing values with increasing amount of PRO to 45.9% and 42.8% after 5 h. By in vitro analysis, the hydrogels with acidic pH values around 3.8 were proven to be active against Candida albicans and Candida glabrata species. The time-killing assay performed during 24 h on Candida albicans in synthetic vagina-simulative medium showed that the hydrogel formulations containing both NYS and PRO presented the faster slowing down of the fungal growth, from colony-forming unit (CFU)/mL of 1.24 × 107 to CFU/mL < 10 (starting from the first 6 h).
Towards the Sustainability of the Plastic Industry through Biopolymers: Properties and Potential Applications to the Textiles World
Authors: Patti Antonella , Acierno Domenico
Published: February 2022

This study aims to provide an overview of the latest research studies on the use of biopolymers in various textile processes, from spinning processes to dyeing and finishing treatment, proposed as a possible solution to reduce the environmental impact of the textile industry. Recently, awareness of various polluting aspects of textile production, based on petroleum derivatives, has grown significantly. Environmental issues resulting from greenhouse gas emissions, and waste accumulation in nature and landfills, have pushed research activities toward more sustainable, low-impact alternatives. Polymers derived from renewable resources and/or with biodegradable characteristics were investigated as follows: (i) as constituent materials in yarn production, in view of their superior ability to be decomposed compared with common synthetic petroleum-derived plastics, positive antibacterial activities, good breathability, and mechanical properties; (ii) in textile finishing to act as biological catalysts; (iii) to impart specific functional properties to treated textiles; (iv) in 3D printing technologies on fabric surfaces to replace traditionally more pollutive dye-based and inkjet printing; and (v) in the implants for the treatment of dye-contaminated water. Finally, current projects led by well-known companies on the development of new materials for the textile market are presented.
Grafted Semiflexible Nunchucks with a Magnetic Bead Attached to the Free End
Authors: Razbin Mohammadhosein , Benetatos Panayotis
Published: February 2022

Semiflexible nunchucks are block copolymers, which consist of two long blocks of high bending stiffness jointed together by a short block of low bending stiffness. Semiflexible nunchucks that consist of two DNA nanorods jointed by a short segment of double-stranded (ds) DNA and confined in two dimensions have been used in recent experiments by Fygenson and coworkers as a tool to magnify the bending fluctuations of the linking dsDNA, which in turn are used to deduce the persistence length of dsDNA. In a recent theoretical analysis, we showed that in a semiflexible nunchuck with one end grafted, the fluctuations of the position of the free end that is transverse to the grafting direction exhibit a pronounced bimodality, provided that the bending stiffness of the hinge is not very large. In this article, we theoretically analyse a grafted semiflexible nunchuck with a magnetic bead attached to its free end. We show that a transverse magnetic field induces an asymmetry in the bimodal distribution of the transverse fluctuations of the free end. This asymmetry is very sensitive to interactions with a magnetic field and, in principle, could be used in magnetometry (the measurement of a magnetic field or the magnetic moment of the bead). We also investigate how the response of the bimodal distribution of the transverse fluctuations of the free end to a magnetic field depends on the bending stiffness of the nunchuck hinge. In addition, we analyse the closely related systems of a single filament and two filaments jointed at a kink point with one end grafted and the other end attached to a magnetic bead.
Comprehensive Areal Geometric Quality Characterisation of Injection Moulded Thermoplastic Gears
Authors: Urbas Uroš , Zorko Damijan , Vukašinović Nikola , Černe Borut
Published: February 2022

Injection moulding is currently the most widely employed production method for polymer gears. Current standardised gear metrology methods, which are based on metal gear inspection procedures, do not provide the key information regarding the geometric stability of injection moulded gears and are insufficient for a thorough gear inspection. The study developed novel areal quality parameters, along with a so-called moulding runout quality parameter, with a focus on the injection moulding method. The developed parameters were validated on twenty-nine gear samples, produced in the same moulding tool using various processing parameters. The gears were measured using a high-precision structured-light 3D scanner. The influence of injection moulding process parameters on the introduced novel quality parameters was investigated. The developed moulding runout quality parameter proved to be effective in evaluating the shrinkage that can occur in the injection moulding process. The novel moulding runout parameter returned an average value of −21.8 μm in comparison to 29.4 μm exhibited by the standard parameter on all the gears, where the negative value points directly to mould shrinkages. The rate of cooling was determined to be the most influential factor for the shrinkage of the gear. The developed areal parameters demonstrated to be advantageous in characterising the deviations on the teeth more comprehensively.
Investigating the Effects of Tobacco Lignin on Polypropylene
Authors: Tahir Irfan , Rapinac John , Abutunis Abdulaziz , Menta Venkata Gireesh
Published: February 2022

The utilization of eco-friendly materials, such as lignin, for higher value product applications became increasingly important as environmental concerns due to global warming increased. Melt blending is one of the easy ways to increase the usage of lignin in commercial applications. However, the degradation of the final product performance and increase in the production time and costs are of major concern. In the current work, the effects of blending lignin, extracted from tobacco plants, with polypropylene (PP) on the injection molding parameters, physical, thermal and mechanical properties are investigated. Blends of lignin (5, 15 and 30% by wt.) with PP were prepared using a Filabot single screw extruder. Results show that tensile strength decreases by 3.2%, 9.9% and 5.4% at 5 wt. %, 15 wt. %, and 30 wt. % of lignin addition, respectively. The tensile stiffness was almost unaffected by the addition of up to 15% lignin, but a 23% increase was observed at 30 wt. % loading. When compared to lignin processed via expensive processes, such as acetylation, tobacco lignin showed superior performance. The DSC results show unaffected crystallization and melting temperatures but a decrease in enthalpies and percentage of crystallinity. The SEM and optical micrographs of the coupon cross-sections show that the extrusion process has achieved a uniform distribution of lignin particles in the PP. Thermogravimetric analysis results show that tobacco lignin accelerates the onset decomposition temperature but does not influence the decomposition peak temperature. The increase in lignin content did not have a significant influence on the injection molding parameters, implying no additional processing costs for adding lignin to the PP. Overall, the performance of the tobacco lignin is comparable, if not better, than that of processed lignin reported in the literature.
Performance Investigation and Cost–Benefit Analysis of Recycled Tire Polymer Fiber-Reinforced Cemented Paste Backfill
Authors: Yu Zhuoqun , Wang Yongyan , Li Jianguang
Published: February 2022

To alleviate the environmental problems caused by scrap tire and tailings disposal, the performance of recycled tire polymer fiber (RTPF)-reinforced cemented paste backfill (CPB) was investigated. Ordinary CPB, commercial poly-propylene fiber (CPPF) and reinforced CPB were also investigated for comparison. Slump tests, unconfined compression tests and a cost–benefit analysis were conducted. The results indicate that the flowability of the RTPF-reinforced CPB decreased with the increasing fiber content. The failure strain, unconfined compressive strength, and toughness values were generally higher than that of ordinary CPB (i.e., CPB without any fiber reinforcement). However, the mechanical properties would not be improved continuously with increasing RTPF content. It was found that the inclusion of RTPFs achieved the best improvement effect with the best mechanical properties of CPB at the fiber content of 0.6%. The failure mode of the RTPF-reinforced CPB was safer than that of the ordinary CPB. Microscopic observations indicated that the bond between RTPFs and the CPB matrix could affect the mechanical properties of the RTPF-reinforced CPB. From the cost–benefit analysis, the inclusion of RTPFs to reinforce CPB could gain relatively high mechanical properties with a low material cost.
Monothetic Analysis and Response Surface Methodology Optimization of Calcium Alginate Microcapsules Characteristics
Authors: Anani Joshua , Noby Hussien , Zkria Abdelrahman , Yoshitake Tsuyoshi , ElKady Marwa
Published: February 2022

Owing to bio-polymer’s low-cost, environmental friendliness and mechanically stable nature, calcium alginate microcapsules have attracted much interest for their applications in numerous fields. Among the common production methods, the Electrospraying technique has shown a great potential due to smaller shape capsule production and ease of control of independent affecting parameters. Although one factor at a time (OFAT) can predict the trends of parameter effect on size and sphericity, it is inefficient in explaining the complex parameter interaction of the electrospray process. In the current study, the effects of the main parameters affecting on size and sphericity of the microcapsules using OFAT were optimized to attain calcium alginate microcapsules with an average diameter below 100 µm. Furthermore, we propose a statistical model employing the Surface Responses Methodology (RSM) and Central Composite Design (CDD) to generate a quadratic order linear regression model for the microcapsule diameter and sphericity coefficient. Experimentally, microcapsules with a size of 92.586 µm and sphericity coefficient of 0.771 were predicted and obtained from an alginate concentration of 2.013 w/v, with a flowrate of 0.560 mL/h, a needle size of 27 G and a 2.024 w/v calcium chloride concentration as optimum parameters. The optimization processes were successfully aligned towards formation of the spherical microcapsules with smaller average diameter of less than 100 µm, owing to the applied high voltage that reached up to 21 kV.
Hydrogel Polyester Scaffolds via Direct-Ink-Writing of Ad Hoc Designed Photocurable Macromonomer
Authors: Fuoco Tiziana , Chen Mo , Jain Shubham , Wang Xi Vincent , Wang Lihui , Finne-Wistrand Anna
Published: February 2022

Synthetic, degradable macromonomers have been developed to serve as ink for 3D printing technologies based on direct-ink-writing. The macromonomers are purposely designed to be cross-linkable under the radical mechanism, to impart hydrophilicity to the final material, and to have rheological properties matching the printer’s requirements. The suitable viscosity enables the ink to be printed at room temperature, in absence of organic solvents, and to be cross-linked to manufacture soft 3D scaffolds that show no indirect cytotoxicity and have a hydration capacity of up to 100% their mass and a compressive modulus in the range of 0.4–2 MPa.
Double-Pulse Ultrasonic Welding of Carbon-Fiber-Reinforced Polyamide 66 Composite
Authors: Zhi Qian , Li Yongbing , Shu Peng , Tan Xinrong , Tan Caiwang , Liu Zhongxia
Published: February 2022

Ultrasonic welding of thermoplastics is widely applied in automobile and aerospace industries. Increasing the weld area and avoiding thermal decomposition are contradictory factors in improving strength of ultrasonically welded polymers. In this study, relations among the loss modulus of carbon-fiber-reinforced polyamide 66 composite (CF/PA 66), time for obtaining stable weld area, and time for CF/PA 66 decomposition are investigated systematically. Then, a double-pulse ultrasonic welding process (DPUW) is proposed, and the temperature evolutions, morphologies and structures of fractured surfaces, and tensile and fatigue properties of the DPUWed joints are measured and assessed. Experimental results show the optimal welding parameters for DPUW include a weld time of 2.1 s for the first pulse, a cooling time of 12 s, and a weld time of 1.5 s for the second pulse. The DPUW process enlarged the weld area while avoided decomposition of CF/PA 66 under appropriate welding parameters. Compared to the single-pulse welded joint, the peak load, weld area, and endurance limit of the DPUWed joint increased by about 15%, 23% and 59%, respectively. DPUW also decreases the variance in strengths of the joints.
π-Conjugated Polymers and Their Application in Organic and Hybrid Organic-Silicon Solar Cells
Authors: Mdluli Siyabonga B. , Ramoroka Morongwa E. , Yussuf Sodiq T. , Modibane Kwena D. , John-Denk Vivian S. , Iwuoha Emmanuel I.
Published: February 2022

The evolution and emergence of organic solar cells and hybrid organic-silicon heterojunction solar cells have been deemed as promising sustainable future technologies, owing to the use of π-conjugated polymers. In this regard, the scope of this review article presents a comprehensive summary of the applications of π-conjugated polymers as hole transporting layers (HTLs) or emitters in both organic solar cells and organic-silicon hybrid heterojunction solar cells. The different techniques used to synthesize these polymers are discussed in detail, including their electronic band structure and doping mechanisms. The general architecture and principle of operating heterojunction solar cells is addressed. In both discussed solar cell types, incorporation of π-conjugated polymers as HTLs have seen a dramatic increase in efficiencies attained by these devices, owing to the high transmittance in the visible to near-infrared region, reduced carrier recombination, high conductivity, and high hole mobilities possessed by the p-type polymeric materials. However, these cells suffer from long-term stability due to photo-oxidation and parasitic absorptions at the anode interface that results in total degradation of the polymeric p-type materials. Although great progress has been seen in the incorporation of conjugated polymers in the various solar cell types, there is still a long way to go for cells incorporating polymeric materials to realize commercialization and large-scale industrial production due to the shortcomings in the stability of the polymers. This review therefore discusses the progress in using polymeric materials as HTLs in organic solar cells and hybrid organic-silicon heterojunction solar cells with the intention to provide insight on the quest of producing highly efficient but less expensive solar cells.
Polymeric Materials Based on Carbon Dioxide: A Brief Review of Studies Carried Out at the Faculty of Chemistry, Warsaw University of Technology
Authors: Florjańczyk Zbigniew , Rokicki Gabriel , Parzuchowski Paweł Grzegorz , Mazurek-Budzyńska Magdalena , Dębowski Maciej
Published: February 2022

Carbon dioxide is an important raw material in many industrial technologies, but it is also one of the greenhouse gases that has to be effectively removed from the environment. This contribution provides a brief overview of carbon dioxide-based polymers developed in the laboratories of the Faculty of Chemistry at Warsaw University of Technology. We present some simple and versatile synthetic approaches that can be used to prepare a library of oligocarbonate diols, polycarbonates, poly(ester-carbonates), poly(ether-carbonates) and various types of polyurethanes, including the newly emerging family of environmentally friendly non-isocyanate polyurethanes. The main synthesis strategy involves the reaction of CO2 with oxiranes to form five-membered cyclic carbonates, which can be utilized as a source of carbonate bonds in polymeric materials obtained by the ester exchange reactions and/or step-growth polyaddition. We also show that cyclic carbonates are valuable starting materials in the synthesis of hyperbranched polymers and polymer networks. The properties of several CO2-based polymers are presented and their potential application as biomaterials, smart materials, and absorbers with a high CO2 capture capacity is discussed.
Comparative Study of Metal Substrates for Improved Carbonization of Electrospun PAN Nanofibers
Authors: Storck Jan Lukas , Wortmann Martin , Brockhagen Bennet , Frese Natalie , Diestelhorst Elise , Grothe Timo , Hellert Christian , Ehrmann Andrea
Published: February 2022

Carbon nanofibers are used for a broad range of applications, from nano-composites to energy storage devices. They are typically produced from electrospun poly(acrylonitrile) nanofibers by thermal stabilization and carbonization. The nanofiber mats are usually placed freely movable in an oven, which leads to relaxation of internal stress within the nanofibers, making them thicker and shorter. To preserve their pristine morphology they can be mechanically fixated, which may cause the nanofibers to break. In a previous study, we demonstrated that sandwiching the nanofiber mats between metal sheets retained their morphology during stabilization and incipient carbonization at 500 °C. Here, we present a comparative study of stainless steel, titanium, copper and silicon substrate sandwiches at carbonization temperatures of 500 °C, 800 °C and 1200 °C. Helium ion microscopy revealed that all metals mostly eliminated nanofiber deformation, whereas silicone achieved the best results in this regard. The highest temperatures for which the metals were shown to be applicable were 500 °C for silicon, 800 °C for stainless steel and copper, and 1200 °C for titanium. Fourier transform infrared and Raman spectroscopy revealed a higher degree of carbonization and increased crystallinity for higher temperatures, which was shown to depend on the substrate material.
Optimization Study on Enhancing Deep-Cut Effect of the Vacuum Distillation Unit (VDU)
Authors: Jin Qibing , Li Ziming , Yan Zhicheng , Wang Bin , Wang Zeyu
Published: February 2022

The vacuum distillation unit (VDU) is the key unit to produce vacuum gas oil and vacuum residue, which has a very important impact on the downstream secondary processing units. The optimization of deep-cut vacuum distillation seeks to improve the yield of heavy vacuum gas oil (HVGO) and its dry point temperature, which is related to the economic benefits of the refinery. In this study, we first established a simple model of a VDU by using the Aspen HYSYS Process simulation software. Then, we built a rigorous model with fast convergence by using the initial values obtained by the simple model. The rigorous model can accurately reflect the refinery’s operation and can make predictions. Then, based on the rigorous model, we increased the flash section temperature (FST) to 420 °C and the steam flow rate (SFR) of the stripping to 26 t/h. We eventually increased the yield of HVGO by 6.3 percentage points to 43.4%, while increasing its D86 95%-point temperature by 31.9 °C to 570.9 °C. In this way, the refinery can effectively optimize the deep-cut vacuum distillation and obtain greater economic benefits.
Finding Religion: Immigration and the Populist (Re)Discovery of Christian Heritage in Western and Northern Europe
Authors: Peker Efe
Published: February 2022

Why and in what ways do far-right discourses engage with religion in geographies where religious belief, practice, and public influence are particularly low? This article examines religion’s salience in the rhetoric of leading right-wing populist parties in eight European countries: the Netherlands, Belgium, France, Switzerland, Austria, Sweden, Denmark, and Norway. Based on a qualitative content analysis of various documents such as party programmes, websites, election manifestos, reports, and speeches of their leadership, the article offers insight into the functions that Christianist discourses serve for anti-immigration stances. The findings are threefold: first, they confirm previous research suggesting that while these parties embrace Christianity as a national/civilizational heritage and identity, they are also careful to avoid references to actual belief or practice. Second, the data suggests, their secularized take on Christianity rests not simply on the omission of theological content, but also on the active framing Christianity itself as an inherently secular and progressive religion conducive to democracy. Third, and finally, they starkly contrast this notion of Christianity with Islam, believed to be incompatible due to its alleged backward and violent qualities. Emphasizing religio-cultural hierarchies—rather than ethno-racial ones—plays an indispensable role in presenting a more palatable form of boundary-making against immigrants, and helps these parties mainstream by giving their nativist cause a liberal and enlightened aura. Preliminary comparisons with traditional conservative parties, moreover, reveal that while some of the latter partially embraced a similar nativism, variations remain across countries.
Daoism and the Operation of the Eastern Stronghold Temple in the Late Imperial China
Authors: Bai Zhaojie , Yao Teng
Published: February 2022

The sacrificial ritual to Mount Yi (Yishan 沂山) or the Eastern Stronghold (Dongzhen 東鎮) was included in the traditional Chinese state ritual system to mountain and water gods, and therefore, originally, it was a Confucian ritual. The Eastern Stronghold Temple was operated by officers and clerks appointed by the government. However, during the late imperial period, the situation changed and the Eastern Stronghold Temple became virtually operated by Daoism, mainly because of the government’s difficulty in maintaining the temple, the growth and power of Daoism, especially the Complete Perfection Daoism popular in northern China, and the further integration of Confucianism, Daoism, and folk beliefs. Daoist priests, who were named “temple guardians”, took responsibilities for guarding temple property, coordinating central and local government’s sacrificial rituals, administrating the daily operation of the temple, conducting reconstruction projects, and incorporating local people’s beliefs. As a result, the temple not only served as an official place of worship but also gained the functions and identity of a Daoist abbey and folk temple. As the first article discussing the Eastern Stronghold Temple in a western language, this study mainly applies the rediscovered source of stone inscriptions preserved in the temple to describe Daoism’s contributions to this religious–political–cultural symbolic site and the complicated relationship between governmental officials, Daoist priests, and local people.
Jawdat Saʿid and the Islamic Theology and Practice of Peace
Authors: Lohlker Rüdiger
Published: February 2022

Among the leading Islamic thinkers and activists promoting a theology of peace based on the Qur‘anic revelation is Jawdat Saʿid. Framing his role by an analysis following the conceptualization of Shahab Ahmed the Qur‘anic context of the ideas of Saʿid are presented, and these ideas are contextualized within the recent Syrian revolution before it turned into civil war. Fundamental ideas of the theology of Saʿid help to explain the thoughts of a lesser known activist of nonviolent action based on a specific and revolutionary interpretation of the Qur‘an.
Semantic Segmentation of Metoceanic Processes Using SAR Observations and Deep Learning
Authors: Colin Aurélien , Fablet Ronan , Tandeo Pierre , Husson Romain , Peureux Charles , Longépé Nicolas , Mouche Alexis
Published: February 2022

Through the Synthetic Aperture Radar (SAR) embarked on the satellites Sentinel-1A and Sentinel-1B of the Copernicus program, a large quantity of observations is routinely acquired over the oceans. A wide range of features from both oceanic (e.g., biological slicks, icebergs, etc.) and meteorologic origin (e.g., rain cells, wind streaks, etc.) are distinguishable on these acquisitions. This paper studies the semantic segmentation of ten metoceanic processes either in the context of a large quantity of image-level groundtruths (i.e., weakly-supervised framework) or of scarce pixel-level groundtruths (i.e., fully-supervised framework). Our main result is that a fully-supervised model outperforms any tested weakly-supervised algorithm. Adding more segmentation examples in the training set would further increase the precision of the predictions. Trained on 20 × 20 km imagettes acquired from the WV acquisition mode of the Sentinel-1 mission, the model is shown to generalize, under some assumptions, to wide-swath SAR data, which further extents its application domain to coastal areas.
The Evolution of the Glacier Surges in the Tuanjie Peak, the Qilian Mountains
Authors: Gao Yongpeng , Liu Shiyin , Qi Miaomiao , Yao Xiaojun , Zhu Yu , Xie Fuming , Wu Kunpeng , Saifullah Muhammad
Published: February 2022

Glacier surges (GSs) are a manifestation of glacier instability and one of the most striking phenomena in the mountain cryosphere. Here, we utilize optical images acquired between 1973 and 2021 to map changes in glacier surface velocity and morphology and characterize differences in surface elevation using multi-source DEMs in the Tuanjie Peak (TJP), located in the Qilian Mountains (QLMs). These data provide valuable insights into the recent dynamic evolution of glaciers and hint at how they might evolve in the next few years. We identified a confirmed surge-type glacier (STG), three likely STGs, and three possible STGs. Our observations show that TJP GSs are generally long-term, although they are shorter in some cases. During the active phase, all glaciers exhibit thickened reservoir areas and thinned receiving areas, or vice-versa. The ice volume transfer was between 0.11 ± 0.13 × 107 m3 to 5.71 ± 0.69 × 107 m3. Although it was impossible to obtain integrated velocity profiles throughout the glacier surge process due to the limitations of available satellite imagery, our recent observations show that winter velocities were much higher than summer velocities, suggesting an obvious correlation between surge dynamics and glacial hydrology. However, the initiation and termination phase of GSs in this region was slow, which is similar to Svalbard-type STGs. We hypothesize that both thermal and hydrological controls are crucial. Moreover, we suggest that the regional warming trend may potentially increase glacier instability and the possibility of surge occurrence in this region.
VO-LVV—A Novel Urban Regional Living Vegetation Volume Quantitative Estimation Model Based on the Voxel Measurement Method and an Octree Data Structure
Authors: Huang Fang , Peng Shuying , Chen Shengyi , Cao Hongxia , Ma Ning
Published: February 2022

Currently, three-dimensional (3D) point clouds are widely used in the field of remote sensing and mapping, including the measurement of living vegetation volume (LVV) in cities. However, the existing quantitative methods for LVV measurement are mainly based on single tree modeling or on the calculation of single tree species’ growth parameters, which cannot be applied to the many tree species and complex forest layer structures present in urban regions, and thus are unsuitable for broad application. LVV measurement is based primarily on vegetation point cloud data, which can be obtained through many methods and often lack some information, thus posing problems in the use of traditional LVV measurement methods. To address the above problems, this paper proposes a novel LVV estimation model, which combines the voxel measurement method with an organizing point cloud based on an octree structure (we called it VO-LVV), to estimate the LVV of typical vegetation and landforms in cities. The point cloud data of single plants and multiple plants were obtained through preprocessing to verify the improvement in the calculation efficiency and accuracy of the proposed method. The results indicated that the VO-LVV estimation method, compared with the traditional method, enabled substantial efficiency improvement and higher calculation accuracy. Furthermore, the new method can be simultaneously applied to scenarios of single plants and multiple plants, and can be used for the calculation of LVV in areas with various vegetation types in cities.
A Method for Efficient Quality Control and Enhancement of Mobile Laser Scanning Data
Authors: Kalenjuk Slaven , Lienhart Werner
Published: February 2022

The increasing demand for 3D geospatial data is driving the development of new products. Laser scanners are becoming more mobile, affordable, and user-friendly. With the increased number of systems and service providers on the market, the scope of mobile laser scanning (MLS) applications has expanded dramatically in recent years. However, quality control measures are not keeping pace with the flood of data. Evaluating MLS surveys of long corridors with control points is expensive and, as a result, is frequently neglected. However, information on data quality is crucial, particularly for safety-critical tasks in infrastructure engineering. In this paper, we propose an efficient method for the quality control of MLS point clouds. Based on point cloud discrepancies, we estimate the transformation parameters profile-wise. The elegance of the approach lies in its ability to detect and correct small, high-frequency errors. To demonstrate its potential, we apply the method to real-world data collected with two high-end, car-mounted MLSs. The field study revealed tremendous systematic variations of two passes following tunnels, varied co-registration quality of two scanners, and local inhomogeneities due to poor positioning quality. In each case, the method succeeds in mitigating errors and thus in enhancing quality.
Global and Regional Variations and Main Drivers of Aerosol Loadings over Land during 1980–2018
Authors: Sun Jie , Ding Kaihua , Lai Zulong , Huang Haijun
Published: February 2022

Aerosol particles originated from anthropogenic emissions, volcanic eruptions, biomass burning, and fossil combustion emissions, and their radiative effect is one of the most uncertain factors in climate change. Meanwhile, aerosol particles in fine particle size could also cause irreversible effects on the human respiratory system. This study attempted to analyse the spatial and temporal variations of global aerosol optical depth (AOD, 550 nm) during 1980–2018 using MERRA-2 aerosol reanalysis products and to investigate the effects of natural/anthropogenic emissions of different types of aerosols on AOD values. The results show that the global annual mean AOD values kept high levels with significant fluctuations during 1980–1995 and showed a consistent decreasing and less volatile trend after 1995. Spatially, the AOD values are relatively higher in the Northern Hemisphere than in the Southern Hemisphere, especially in North Africa (0.329), Northern India (0.235), and Eastern China (0.347), because of the intensive natural/anthropogenic aerosol emissions there. The sulphate-based aerosols emitted by biomass burning and anthropogenic emissions are the main types of aerosols worldwide, especially in densely populated and industrialized regions such as East Asia and Europe. Dust aerosols are also the main aerosol type in desert areas. For example, the AOD and AODP values for the Sahara Desert are 0.3178 and 75.32%, respectively. Both black carbon aerosols (BC) and organic carbon aerosols (OC) are primary or secondary from carbon emissions of fossil fuels, biomass burning, and open burning. Thus, the regions with high BC and OC aerosol loadings are mainly located in densely populated or vegetated areas such as East Asia, South Asia, and Central Africa. Sea salt aerosols are mainly found in coastline areas along the warm current pathway. This study could help relevant researchers in the fields of atmospheric science, environmental protection, air pollution, and ecological environment to understand the global spatial–temporal variations and main driving factors of aerosol loadings.