bluuebunny/crossref_metadata_2025 huggingface dataset:
Autonomía de la mujer y violencia de pareja: análisis de la Encuesta Demográfica y de Salud Familiar 2019
Authors:   , Baron Lozada Francisco Alejandro , Basualdo Melendez Gianfranco Wilfredo
Published: December 2024

Evaluar cómo la autonomía de la mujer está relacionada con la violencia de pareja (VP) contra las mujeres en edad fértil. Se llevó a cabo un estudio secundario utilizando datos de la Encuesta Demográfica y de Salud Familiar (ENDES) del año 2019. La muestra estuvo compuesta por mujeres de entre 15 y 49 años que están casadas o conviven con una pareja. Se utilizó un modelo de regresión lineal generalizada de la familia Poisson para calcular las razones de prevalencia ajustadas (RPa) que describen la relación entre la autonomía de las mujeres y la violencia de pareja, junto con sus respectivos intervalos de confianza del 95%. Se examinaron los datos de 18,621 mujeres. Se observó que un mayor porcentaje de mujeres mostraba niveles bajos de autonomía (42%), seguido de niveles moderados (39.2%) y altos (18.8%). La prevalencia de violencia de pareja fue del 40.1%, siendo principalmente de naturaleza psicológica/verbal (38.8%), seguida de violencia física (8.8%) y sexual (2.3%). En un modelo ajustado, se encontró que las mujeres con baja autonomía tenían una mayor prevalencia de violencia de pareja en comparación con aquellas con alta autonomía (RPa: 1.15, IC 95%: 1.01-1.31), especialmente en términos de violencia psicológica/verbal (RPa: 1.15, IC 95%: 1.01-1.31). No se encontró una relación entre la violencia física o sexual y el nivel de autonomía de las mujeres por parte de la pareja. De cada diez, cuatro mujeres en edad fértil han tenido VP en el último año. En términos generales, las mujeres con baja autonomía tienen más probabilidades de padecer VP que las mujeres con autonomía alta.
Correlación de la escala clínica de fragilidad y el algoritmo de fragilidad propuesto por la Universidad Dalhousie en adultos mayores
Authors:   , Velarde Carranza Sandy Melva Johana , Valer Quispe Marwy
Published: December 2024

Introducción. La fragilidad es definida como el deterioro funcional en relación con el envejecimiento. En la actualidad no existe una medida estandarizada para su diagnóstico. Objetivo. Determinar la correlación de la Escala Clínica de Fragilidad (CFS) y el algoritmo propuesto por la Universidad Dalhousie en adultos mayores durante la pandemia por COVID-19. Métodos. Se examinó a 444 pacientes en diferentes niveles asistenciales, la fragilidad se medió con la CFS y el algoritmo. Se utilizaron estadísticas descriptivas para presentar las variables. Se aplicaron modelos de regresión lineal para cuantificar la correlación entre los puntajes de ambos instrumentos. Resultados. El algoritmo indicó un 21.17% de adultos mayores ligeramente frágiles, 20.95% vulnerables y 8.33% severamente muy frágiles. Por otro lado, con la CFS hubo 28.38% adultos mayores ligeramente frágiles, 25.9% moderadamente frágiles y 2.93% vulnerables no dependientes. Se encontró una correlación de 54.5% de los casos y obteniendo un Rho de Spearman de 0.79 con un valor de p <0,001. Conclusión. Hay un cierto nivel de correlación según el modelo de regresión lineal pero no lo suficiente para ser estandarizada por lo cual se recomienda el uso de otros instrumentos de manera individualizada.
NLR y PLR como predictores de mortalidad en adultos mayores hospitalizados con Covid-19 en Lambayeque 2020
Authors:   , Ortega Rojas Solangel
Published: December 2024

Objetivos: El valor pronóstico del razón neutrófilo-linfocito (NLR) y razón plaqueta-linfocito (PLR) en pacientes con COVID-19 ha sido poco descrito en adultos mayores. Nos planteamos como objetivo estimar el valor pronóstico del NLR y el PLR determinando la mortalidad de adultos mayores de 60 años hospitalizados por COVID-19 en tres hospitales de Perú de marzo a mayo de 2020. Métodos: Realizamos un análisis secundario de los datos de una cohorte retrospectiva llevada a cabo en Lambayeque - Perú del 18 de marzo al 13 de mayo de 2020. Se incluyeron adultos mayores hospitalizados por COVID-19. La variable de resultado fue la mortalidad intrahospitalaria por todas las causas, mientras que la variable de exposición fue el NLR y el PLR (categorizados en terciles y numéricamente, realizando una transformación logarítmica). Se incluyeron variables sociodemográficas, comorbilidades, funciones vitales, marcadores de laboratorio y tratamiento recibido durante la estancia hospitalaria. Se evaluó la asociación entre NLR y PLR mediante la razón de hazard (HR) en un modelo de regresión de Cox. Estimamos la HR con sus respectivos intervalos de confianza del 95% (IC 95%). Estimamos las curvas ROC acumulativas/dinámicas dependientes del tiempo e informamos del área bajo la curva ROC (AUC-ROC) para la mortalidad a los 15, 30 y 60 días con sus respectivos intervalos de confianza simultáneos (bandas de confianza [CB]). Además, estimamos un punto de corte óptimo basado en los estadísticos de rango máximo seleccionados. Resultados: Se analizó a un total de 262 adultos mayores hospitalizados, de los cuales el 71,8% (n=188) eran varones con una mediana de edad de 70 años (intervalo intercuartílico: 65-78). La media de NLR y PLR fue de 16,8 (IC 95%: 14,9-18,7; DE: 15,5) y 50,3 (IC 95%: 44,6-55,9; DE: 46,3), respectivamente...
Ejercicio físico aeróbico y rendimiento académico en el entorno E-learning de los estudiantes VI ciclo de una universidad privada 2023 -1
Authors:   , Anton Talledo Carlos Edgard , Huapaya Basurco Maria Elena
Published: December 2024

Los ejercicios aeróbicos tienen un impacto significativo en el desarrollo físico y mental de una persona. El propósito de este estudio es investigar la relación entre el ejercicio aeróbico y el rendimiento académico en un entorno de aprendizaje en línea para estudiantes de VI ciclo de una universidad privada en el año 2023-1. Este estudio fue diseñado mediante un enfoque cuantitativo utilizando escalas descriptivas correlacionales y un enfoque transversal no experimental. La población bajo investigación comprendió a 80 estudiantes del VI ciclo. Se adaptó el instrumento para ejercicio físico aeróbico en base al contenido consolidado por (Pate 1995) y (Álvarez 2010). Para rendimiento académico se adecuó, la información teórica (Santos y Vallelado, 2013), se realizó la validación y confiabilidad por jueces expertos. Para los resultados de este análisis cuantitativo descriptivo y correlacional, se utilizó el análisis paramétrico de Kolmogorov y Smirnov, estableciendo la simetría de distribución y el coeficiente de Spearman. Luego, se llevaron a cabo pruebas de hipótesis para cada variable. Como resultado, el nivel de significancia fue menor a 0.05 y se aceptó la hipótesis alternativa (Ha) de que existe una relación estadísticamente significativa entre la intensidad directa e intermedia (p = .000; rho = .462). entre dos variables en un contexto de aprendizaje en línea. En conclusión, este estudio apoya la idea de que la actividad física aeróbica tiene un efecto positivo estadísticamente significativo sobre el rendimiento académico.
WITHDRAWN: Salvia sclarea L.-Mediated Synthesis of Silver Nanoparticles: Characterization, Secondary Metabolite Influence, and Antibacterial Activity Assessment
Authors: Arslan Elif , Yuca Esra , Servi Huseyin , Arayıcı Pelin Pelit , Erişen Semiha
Published: December 2024

The full text of this preprint has been withdrawn, as it was submitted in error. Therefore, the authors do not wish this work to be cited as a reference. Questions should be directed to the corresponding author.
Development and Validation of Mental Health Literacy Assessment Scale among Community Health Workers and Volunteers in Nepal
Authors: Paudel Shishir , Chalise Anisha , Shakya Prashabdhi , Bhandari Tulsi Ram
Published: December 2024

Background:
Mental health literacy (MHL) is crucial for effective mental health care, especially in low- and middle-income countries like Nepal. Community health workers (CHWs) and volunteers play pivotal role in improving mental health, but their level of MHL is unknown as the existing assessment tools are not tailored to them. This study aims to develop and validate the Mental Health Literacy Assessment Scale (MHLAS) among CHWs and health volunteers.
Method:
The authors reviewed online literatures and consulted experts to generate an item pool that was refined through cognitive interviews with CHWs. Content validity was assured on the basis of the ratings of six experts. A cross-sectional survey was performed among 233 CHWs and health volunteers. Exploratory factor analysis (EFA) using Varimax rotation was performed to identify latent variables with factor loadings > 0.4. Confirmatory factor analysis (CFA) was employed to validate the model, using indices such as RMSEA < 0.05, SRMR < 0.08, CFI ≥ 0.90, and TLI ≥ 0.90. Reliability was assessed through Cronbach’s alpha where alpha coefficient > 0.70 indicated internal consistency.
Result:
The EFA resulted in a four-factor structure, with 50.75% of the total variance explained by positive mental health behaviors (21.44%), misconceptions about mental health (14.24%), symptoms of mental distress (8.70%), and mental health stigma (6.37%). The CFA demonstrated excellent model fit, with indices such as the normed chi-square (1.307), CFI (0.951), TFI (0.943), and RMSEA (0.036). The scale displayed strong convergent and discriminant validity, with an AVE > 0.431 and a CR > 0.7 for all factors. Internal consistency was confirmed, with a Cronbach’s alpha value of 0.797 for the overall scale.
Conclusion:
The MHLAS has robust psychometric properties and comprehensive coverage of mental health literacy components, making it a valuable tool for both research and practical applications among community health workers and volunteers in low- and middle-income countries.
Amino acid variants in the HLA-DQA1 and HLA-DQB1 molecules explain the major association of variants with relapse status in pediatric patients with steroid-sensitive nephrotic syndrome
Authors: Yin Hui , Yu Sijie , Chen Xuelan , Yang Haiping , Wang Mo , Li Qiu , Chan Han
Published: December 2024

Background Management of patients with steroid-sensitive nephrotic syndrome (SSNS) is challenging because of frequent relapses. Causal variants in the human leukocyte antigen (HLA) class II region that are associated with relapse remain undetermined.
Methods We collected a cohort of East Asian individuals comprising 206 pediatric patients with SSNS and 435 healthy controls from Southwest China. Ninety children with steroid-sensitive nephrotic syndrome without relapse (SSNSWR) and 116 children with steroid-dependent and/or frequent relapse nephrotic syndrome (SDNS/FRNS) were genotyped using Sanger sequencing. We then measured the transcriptional level, allele expression imbalance (AEI) and functional proteins of HLA-DQA1 and HLA-DQB1 in different stages of SDNS/FRNS.
Results rs1464545187 in ANKRD36 was associated with an approximately 1.69-fold greater risk for SSNSWR (P=0.04; 95% confidence interval [CI], 1.05-2.72). Clustered risk variants in HLA-DQA1 and HLA-DQB1 were significantly associated with SDNS/FRNS (rs1047989: P=2.26E-07, odds ratio [OR]=2.25, 1.65-3.05; rs9273471: P=5.45E-05, OR=1.84, 1.37-2.46; HLA-DQB1*06:02: P=0.017, OR=0.19, 0.04-0.77). The genotype distributions of rs1047989, 2:171713702, rs1049123, rs9273471, and HLA-DQB1*06:02 in patients with SSNS were significantly different from those in healthy controls. rs1047989 (HLA-DQA1) was significantly associated with a greater number of infections at relapse in SDNS/FRNS patients (P=0.045, OR=6.79, 95% CI: 1.29-168.52). Flow cytometry showed that the proportion of cells expressing HLA-DQA1+/DQB1+ (HLA-DQA1+, P=0.0046; HLA-DQB1+, P=0.0045) was lowest in the relapse stage. In addition, the mRNA levels of HLA-DQA1 and HLA-DQB1 were significantly greater in the relapse group than in the remission group (HLA-DQA1, P=0.03; HLA-DQB1, P=0.002). No significant AEIs were detected in the different stages of SDNS/FRNS. The rs1047989 variant is likely to affect the structure and stability of HLA-DQA1.
Conclusion rs1464545187 is a risk locus for SSNSWR but not SDNS/FRNS in Chinese children. Functional variations in HLA-DQA1 and HLA-DQB1 are implicated in regulating the immune response of SSNS patients, which may explain the typical triggering of SDNS/FRNS onset by infections.
Impact of combined application of biochar and phosphorus on maize production and soil properties in Yellow River Delta: a comparison between contrasting climatic conditions
Authors: Tang Xiaoqi , Jiang Chunming , Li Hongjie , Tian Jing , Li Dawei , Zhang Xuan , Ge Xiuli , Liu Xia , Liu Guoli , Gao Wenjun , Li Wenjuan
Published: December 2024

Yellow River Delta’s arable land had great potential for grain production if reasonable agronomic measures were taken. To date, the question of whether and how biochar (C) and phosphorus (P) addition jointly regulates maize production in this area remains unclear. Consequently, a two-year (2021–2022, with contrasting climatic conditions) field experiment including three biochar intensities ((0 (C0), 5000 (C1), and 10000 (C2) kg ha− 1 )), three phosphorus fertilization levels (0 (P0), 100 (P1), and 200 (P2) kg P2O5 ha− 1 ), and their combinations was conducted in Wudi, Shandong province, China. Across the two-year study, C rather than P addition exerted a significantly positive impact on maize yield, yield component parameters, and nutrient (nitrogen (N) and P) accumulation (P < 0.01). Separately for the two years, maize growth and nutrient uptake under unfavorable weather conditions (excessive rainfall) of 2021 were all obviously depressed (P < 0.01) relative to 2022, while these stimulated magnitudes by C in 2021 became more marked than in 2022. Correspondingly, C addition enhanced a greater proportion of dry matter and nutrient remobilization in 2021. On the other hand, soil physical and chemical properties were mostly improved by C addition, in which the increased extent of hydraulic conductivity (Ks) was much more dramatic. Taken together, these plant and soil mechanisms could alleviate the adverse effect induced by heavy-rainfall weather conditions on crop shoot and root, respectively, and explain the higher promotion effect of C addition on maize yield in 2021 than in 2022. More importantly, negative interactions of C×P on soil available P and phosphorus activation coefficient (PAC) (P < 0.01) were captured, which might contribute to the lack of synergistic effects of C×P on maize growth. These results suggested that C addition could enhance maize production and ensure crop yield stability if facing severe weather conditions; while the combined incorporation of this kind of C and P we used (especially high-amount addition treatment of C2P2) was not recommended, and other types of biochar accompanied with P fertilizer needed to be tested in the Yellow River Delta. Overall, the present study delivered useful insight into the sustainable utilization of C and P fertilizer in saline-alkali soils.
C-peptide Involvement in the Progression of Type 2 Diabetes Mellitus Through Triglyceride -centered Lipid Metabolism Disorders
Authors: Li HuiFang , Zhu ZhaoMing
Published: December 2024

Purpose: Fasting C-peptide (FCP), co-secreted with insulin, plays a critical role in the development of diabetic complications, with both deficiency and excessive secretion linked to adverse outcomes. Type 2 diabetes mellitus (T2DM) is mainly characterized by lipid metabolism disorders, with elevated triglyceride (TG) levels. This study aimed to determine the relationship between FCP levels and lipid metabolism disorders centered around TG and related clinical indicators.
Method: Medical records from 1034 patients with T2DM were reviewed, eventually including 607 patients with a median age of 63 years. Pearson’s correlation analysis assessed the correlation between C-peptide levels and metabolic variables. The area under the receiver operating characteristic curve evaluated the predictive performance of TG, uric acid (UA), and fasting blood glucose levels for high C-peptide levels. Univariate and multivariate logistic regression analyses identified independent risk factors affecting C-peptide levels.
Results: The median patient age was 63 years, with a diabetic kidney disease prevalence of 47.78%. Patients were divided into quartiles based on FCP levels, revealing significant differences in TG, TyG, and AIP values (P < 0.01). Positive correlations existed between FCP and TG (r = 0.202**), TyG (r = 0.247), AIP (r = 0.285) (P < 0.001), UA (r = 0.248**), and creatinine (r = 0.234**). Stratified analysis revealed TG and UA significantly increased C-peptide levels (TG: odds ratio [OR] = 5.782, 95% confidence interval [CI] = 3.526–9.480, P < 0.001; UA: OR = 4.382, 95% CI = 2.707–7.094, P < 0.001), with TG identified as an independent risk factor (OR = 1.223, 95% CI = 1.044–1.433, P = 0.013).
Conclusion: FCP levels in patients with T2DM are closely associated with lipid metabolism disorders, particularly TG, contributing to target organ damage. Supplementation with C-peptide may not be beneficial for delaying the progression of T2DM or its complications.
Exploring Rural Teachers’ Self-efficacy Beliefs Toward Online Teaching: Measurement, Typologies and Predictors
Authors: Zhao Shu , Hou Rui , Liu Meiyan , Luo Yuqiao
Published: December 2024

Promoting the reform of online education is much more challenging in rural schools, and the role of teachers should be emphasized. Based on that, this study mainly focuses on teachers’ self-efficacy beliefs toward online teaching according to Technology Acceptance Model 3.0. Specifically, the present study develops an instrument for measuring teachers’ self-efficacy beliefs toward online teaching. Data were collected from 556 valid responses in rural schools of Guangdong, China. Firstly, factor analysis confirms the validity and reliability of the measurement instrument of teachers’ self-efficacy beliefs toward online teaching. Secondly, the latent profile analysis is conducted and reveals three typologies of rural teachers according to the measurement of self-efficacy beliefs toward online teaching, including “peripheral online teaching practitioners”, “lecture-oriented online teaching practitioners” and “leading online teaching practitioners”. Thirdly, the multiple analysis of variance shows the important role of schools’ ICT vision and professional development support in developing teachers’ self-efficacy beliefs toward online teaching. According to the results, it is suggested that during the process of promoting the development of online education in underdeveloped rural area, more emphasis should be placed on the collaboration between local education departments and school administrators in the aspect of teacher professional development. Specifically, designing diversity-oriented teacher training programs, providing typology-oriented teacher development support and supporting empowerment-oriented school transformation are promising strategies to improve the teachers’ self-efficacy belief toward online teaching and deepen the reform of online education in rural Chinese schools.
Increasing likelihood of heat-related mortality events with global warming: a continental epidemiological extreme event attribution study
Authors: Beck Thessa , Gudmundsson Lukas , Schumacher Dominik , Seneviratne Sonia , Achebak Hicham , Ballester Joan
Published: December 2024

Heat has become Europe's leading cause of weather-related fatalities, with half of the summer burden attributed to anthropogenic warming. During the record-breaking 2022 summer, more than 11,000 heat-related deaths were estimated to have occurred during a single week. It remains unknown, however, how climate change has influenced the likelihood of this extreme event. Here, by combining well-established Extreme Event Attribution methods with state-of-the-art epidemiological models, we quantify for the first time how global warming has altered the occurrence probabilities of extreme heat-related mortality events such as in the 2022 summer.
First, we find that temperature-based extreme event attribution studies are insufficient proxies for accurately attributing associated health impacts. We estimate that 2022-like events are, averaged across Europe, three times [95 % CI 1.02 – 18.6] more likely to occur in 2022 than during pre-industrial times. In Southern Europe, where heat-related mortality rates are already two times higher than the European average, the likelihood of extreme heat-related mortality events has increased even more rapidly, i.e., 2022-like events are associated with a 30-fold [95 % CI 3.8 – 2,354.2] probability surge. Our results highlight that anthropogenic climate change has already substantially increased the probability of extreme heat-related mortality events such as those of the 2022 summer, especially in the South of Europe, and that women and the elderly are the most vulnerable groups. Lastly, we find that 2022-like extreme heat-related mortality events in Europe are expected to occur every eight [95% CI 3.6 – 20.8] years at 1.2 ºC of global warming, every five [95% CI 2.0 – 12.7] years at 1.5 ºC, and every two and a half [95% CI 1.1 – 9.5] years at 2.0 ºC.
The study underlines the urgency of implementing mitigation and adaptation measures to limit global warming and reduce the impact of anthropogenic extreme heat on vulnerable populations.
Machine tool model correction assisted by dynamic evolution sequence
Authors: Lin Weihao , Zhong Peng , Wei Xindi , Zhu Li , Wu Xuanlong
Published: December 2024

In the simulation analysis of large-scale industrial instruments such as machine tools, in order to ensure simulation accuracy, model parameter correction is necessary. This research presents a machine tool model correction method assisted by dynamic evolution sequence (DES). The method first introduces a dynamic evolution method to generate a uniformly distributed sequence, replacing the traditional sequence used in Kriging surrogate models, and constructing a more accurate Kriging surrogate model for machine tools. Additionally, incorporating a dynamic evolution sequence instead of a random sequence improves the search space coverage of the Heterogeneous Comprehensive Learning Particle Swarm Optimization (HCLPSO) algorithm. The results of numerical examples demonstrate that the finite element model, corrected using the proposed method, accurately predicts the true displacement responses of the machine tool. This method offers a new solution for addressing large-scale machine tool static model correction problems.
Electrochemical machining with a variant cathode for aero-engine stator vanes
Authors: Zhou Xinqun , Zhu Dong , Jiao Erhao , Huang Hongxin , Chen Liyong
Published: December 2024

Stator vanes with dual-platform (inner and outer platform) structures are essential components of aero engines. Electrochemical machining (ECM) is a highly efficient, low cost and high-quality method of machining stator vanes. During ECM, the inner walls of the platforms (IWPs) of the stator vane are easily affected by stray currents, making it difficult to control the machining accuracy. In order to improve the IWP machining quality, an ECM method based on a variant cathode is proposed in this work. When ECM of stator vanes is performed using this method, the three parts of the variant cathode feed synchronously to the vane surface and IWPs respectively. A cathode cooperative motion device is designed for this machining method. The distribution of the current density and flow velocity in the machining gap is obtained through the simulation. The uniformity of current density in the machining area of the IWP is improved by 67.1% and increases the flow velocity of the electrolyte by 9% over those provided by the traditional method. Furthermore, the proposed method enhances the IWP concentrated dissolution capability and reduces the impact of stray currents, resulting in a 41.8% reduction in the taper angle of the IWPs. Experiments are carried out, and the results show that compared with the traditional method, the IWP profile accuracy is improved by 54.4%, and the surface quality is improved by 49.1%. The results are close to those obtained from simulations and theoretical analysis, which verifies the effectiveness of the proposed method.
Early Effects of Communities That Care on System Change Outcomes: A Quasi-Experimental Study
Authors: Röding Dominik , von Holt Isabell , Decker Lea , Walter Ulla
Published: December 2024

Background: In 2009, the Communities That Care (CTC) approach, widely implemented worldwide, was introduced in Germany across five municipalities. Since then, an increasing number of German municipalities have adopted CTC. While the approach has shown effectiveness internationally, its effectiveness in Germany has not yet been evaluated. The CTC community change model posits that fostering a science-based prevention approach (adoption), sectorial collaboration (SC), and prevention collaboration (PC) leads to increased implementation and reach of evidence-based prevention programs. Over time, this approach aims to achieve measurable reductions in youth problem behaviors. This paper examines the early effects of CTC on adoption, SC, and PC.
Methods: Analyses were conducted using longitudinal data from a Community Key Informant (CKI) survey administered in 2021 (baseline) and 2023 (post-intervention). Data from 318 CKIs across 17 intervention communities (IC) and 15 comparison communities (CC) were analysed using three-level mixed models. The primary outcome is adoption.
Results: The final adjusted models revealed significant baseline differences between ICs and CCs in the outcomes of Adoption and SC, with higher baseline levels for ICs. Unlike the other outcomes, no significant difference in baseline levels of PC was found. ICs experienced a non-significant increase in Adoption (OR 1.248; 95% CI 0.337-4.614) and PC (γ = 0.070, SE = 0.126, p=.579) relative to CCs over time. In contrast, ICs showed no significant change in SC scores post-intervention, whereas CCs experienced an non-significant increase during the same period (γ = -0.200, SE = 0.122, p=.105).
Conclusions: The COVID-19 pandemic affected the study period, preventing the investigation of CTC under normal conditions. Despite this, the primary and one of the secondary outcomes showed a weak and non-significant change in the direction intended by CTC. Given the limited implementation of CTC due to the pandemic, this is considered a tentative indication of CTC's effectiveness in Germany. To confirm this, the CTC-EFF study should be extended with at least one additional survey wave to evaluate CTC's effects under normal conditions.
Study registration: This study was registered with German Clinical Trial Register: DRKS00022819 on Aug 18, 2021.
Single-cell sequencing reveals the role of SALL4 in cervical cancer development
Authors: Tonghui Bao , Wufen Li , Lin Qi
Published: December 2024

Objective: This study aims to investigate the role of SALL4 in the development and progression of cervical cancer, particularly its impact on the proliferation, migration and adhesion of HeLa cells, and to explore the clinical potential of SALL4 as a therapeutic target.
Methods: Single-cell sequencing technology was utilized to analyze the cellular characteristics of cervical cancer tumor cell populations, and transcriptomic data were integrated to assess the differential expression of SALL4. Additionally, both in vitro and in vivo experiments were conducted to evaluate the effect of SALL4 inhibition on cell proliferation, migration, adhesion, and its regulation of collagen content and fibrosis.
Results: High expression of SALL4 significantly promoted the proliferation, migration, and adhesion of cervical cancer cells. After SALL4 knockout, the migration and proliferation rates were significantly lower than those of HeLa cells. Immunofluorescence and in vivo experiments showed that SALL4 knockout cells exhibited a significantly reduced tumor formation ability, with lower proliferation and fibrosis levels compared to HeLa cells.
Conclusion: High expression of SALL4 promotes cervical cancer progression, while inhibition of SALL4 expression effectively suppresses cancer development. As a critical regulatory factor, SALL4 has the potential to become a therapeutic target for cervical cancer, and its application in cervical cancer treatment warrants further exploration.
Research on the Optimization of Supply Chain Decisions for Green Agricultural Products Based on Farmers' Risk Preferences and Disaster Year Subsidies
Authors: Li Fuchang , Gui Yutong , Du Yadong , Wen Jing
Published: December 2024

Under the conditions of agricultural insurance and the uncertainty of agricultural product output, this study considers farmers constrained by funding and government subsidies during disaster years. An order contract supply chain is constructed, comprising farmers, distributors, and insurance companies. Farmers exhibit varying risk preferences and cultivate agricultural products with different levels of greenness. A three-stage game model is employed to derive the optimal planting scale for farmers, the optimal wholesale price for distributors, and the optimal premium rate for insurance companies. The results indicate that government disaster year subsidies directly increase the Conditional Value-at-Risk (CVaR) of farmers, although a maximum subsidy rate exists to prevent inequity. Enhancing the greenness of agricultural products has a positive impact on agricultural production. As the probability of disaster years increases, loan guarantee insurance becomes more effective in expanding farmers' planting scales, while yield guarantee insurance demonstrates superior performance in improving farmers' CVaR. The practical value of this study lies in providing farmers with optimal decision-making frameworks and profit calculations for loan guarantee insurance and yield guarantee insurance under varying disaster-year probability scenarios. Additionally, it explores the impact of government subsidies during disaster years, the greenness level of agricultural products, and the risk of crop failure on changes in farmers' value. These findings contribute to the optimization of farmers' decision-making processes, enhancement of their economic welfare, and the promotion of sustainable agricultural development, ultimately improving the livelihoods of farmers.
Using LDpred2 to Adapt Polygenic Risk Score Techniques for Methylation Score Creation
Authors: Sandås Kristoffer , Spindola Leticia , Løkhammer Solveig , Stavrum Anne-Kristin , Andreassen Ole , Tesfaye Markos , Hellard Stéphanie Le
Published: December 2024

Objective: This study sought to determine if the R package LDpred2, designed for polygenic risk score creation for genome-wide association studies using summary statistics, could be adapted for deriving DNA methylation scores from methylome-wide association studies. Recognizing that linkage disequilibrium, used as prior in LDpred2, does not apply to methylation, we explored co-methylated regions and topologically associating domains as alternative structural priors for correlation between methylation sites. A genomic sliding-window approach was also tested. The performance of the LDpred2-based models was evaluated on methylation data from schizophrenia and control samples (N=1,227).
Results: LDpred2 models employing topologically associating domains and sliding window clusters as priors performed similarly to existing methods, explaining approximately 3.6% of schizophrenia phenotypic variance. The co-methylated regions model underperformed due to insufficient clustering of probes. The similarity in performance between the model using topologically associating domains and a null model consisting of random clusters suggests that the structural information provided by these domains enhances performance only marginally. In conclusion, while LDpred2 can be adapted for methylation data, it does not substantially enhance methylation score performance over existing methods, and the choice of structural prior may not be a critical factor.
Evaluation of Vanadium contamination and environmental peril in some particular waste wasteyards
Authors: Askari Kaveh Ostad Ali , Kianmehr Peiman
Published: December 2024

Waste removal in landfills has caused in significant vanadium contamination of soil and ecologies. This study evaluated vanadium contamination and potential ecological risks in several selected landfills in southeastern Iran. In this study, soil models were collected from dynamic landfills applying a stainless-steel soil auger at a depth of 0-21 cm. Five subsamples were collected from each model site. Control models were taken from areas without manufacturing activity or landfills. Soil models were air dehydrated at room temperature, ground in an agate mortar and pestle and stored in a properly labeled polyethylene bag prior to examination. Vanadium examination was performed applying the FS240AA atomic captivation spectrophotometer and the produced information was examined applying IBM SPSS version 21.0 and Ms-Excel 2007. The average vanadium attentions of the landfills surveyed were found in the subsequent demand: North Lut Landfill> Southern Lut Landfill> Lut Plain Landfill> Central Lut Landfill. Satisfactory possible environmental peril indicators were experimental in Easteren Lut, Lut plains, and North Lut landfills, while the southern Lut landfills had high possible environmental perils rice field. In addition, the contamination index played that all landfills examined were heavily contaminated. Numerical analysis played no important variation in vanadium absorption in the landfills examined (p> 0.06). In addition, there was a strong positive correlation amongst the Lut Plain / Nnewi (r = 0.629), Southern Lut / Nnewi (r = 0.621), and Southern Lut / Central Lut (r = 0.849) landfills. This indicates that the metals found in the landfill have the same source.
РУССКИЕ УЧЕНЫЕ В СЛОВАКИИИНТЕРАКЦИЯ СЛОВАЦКОЙ И РУССКОЙ НАУКИ(1920–1945)
Authors: Гарбульова Л.
Published: December 2024

Первые русские ученыеэмигранты, покинувшие Россию после революции, прибыли в Словакию в начале 1920х гг., чтобы поступить на факультет недавно основанного Университета им. Яна Амоса Коменского в Братиславе. Доля интеллектуалов в русской общине выросла в 1930х, когда в Словакию приехала большая группа русских инженеров и техников. В независимой Словацкой Республике были созданы новые высшие учебные заведения (в основном в области технологий и естественных наук), что привлекло в страну еще больше российских специалистов. Деятельность российских ученых (исследовательская и педагогическая) явилась ценным вкладом в развитие высшего гуманитарного и технического образования и формирование отдельных дисциплин в межвоенной Словакии. Интенсивное и плодотворное научное и профессиональное сотрудничество между словацкими и российскими учеными стало неотъемлемой частью развития науки в России и Словакии в первой половине XX века.

Immigrants who left Russia after the revolution attracted public attention in Slovakia in the early 1920s. At that time first Russian scholars arrived in Slovakia to join the faculty of the newly founded Jan Amos Komensk University in Bratislava. New tertiary education institutions were established in the independent Slovak Republic, which attracted more Russian specialists to the country. Russian scholars teaching and research work was a valuable contribution to the development of tertiary humanities and technical education in the interwar Slovakia and the genesis of individual disciplines. Intensive and fruitful scientific and professional cooperation between Slovak and Russian scholars was an integral part of Russian and Slovak science development in the first half of the 20th century.
ФОРМИРОВАНИЕ МЕМОРИАЛЬНОГО ПРОСТРАНСТВАРУССКОГО МИРА В ЛАТИНСКОЙ АМЕРИКЕВ КОНТЕКСТЕ ИСТОРИИ ДВУХ ВОЛН ЭМИГРАЦИИ
Authors: Мосейкина М.Н.
Published: December 2024

Латинская Америка в ХХ в. стала одним из центров русского рассеяния за рубежом, сюда направлялись потоки первой и второй волн эмиграции: к представителям белого движения, казачества, техноэлиты после II мировой войны присоединились перемещенные лица, демонстрировавшие собственный опыт правовой, экономической и социокультурной адаптации. Представляется актуальным изучение военнополитического, экономического и культурного потенциала Русского мира в странах Латинской Америки, благодаря которому формировалось мемориальное пространство, продолжающее существовать и сегодня. В статье определяются места и модели памяти русской диаспоры, связанные с историей русской эмиграции в этом регионе.

Latin America became one of the centers of the Russian resettlement abroad, where the first and second waves of emigration flowed in the 20th century. These were representatives of the white movement, the Cossacks, the technoelites, who were joined by displaced people after World War II. They demonstrated their own experience in legal, economic and sociocultural adaptation. It is very useful to examine the experience of the militarypolitical, economic and cultural potential of the Russian world in the countries of Latin America. Thanks to it a memorial space was formed, which continues to exist today. The article identifies the places and memory models of the Russian diaspora associated with the history of Russian emigration in this region.
ПЕДАГОГИЧЕСКОЕ НАСЛЕДИЕ РОССИЙСКОЙ ЭМИГРАЦИИВ МИРОВОМ ОБРАЗОВАТЕЛЬНОМ ПРОСТРАНСТВЕ
Authors: Седова Е.Е.
Published: December 2024

В статье рассматриваются пути взаимодействия и взаимовлияния педагогики российского зарубежья и западной педагогики ХХ века в 19201950 гг. Формирование образовательного пространства русской эмиграции, причины и факторы, оказавшие влияние на её становление. Особенности педагогических взглядов и идей наиболее значительных ученых и педагогов российского зарубежья (С. Гессен П. Сорокин, Е.В. Антипова), оказавших влияние на развитие педагогических идей в ХХ веке.

The article deals with the ways of interaction and mutual influence of pedagogy of the Russian abroad and Western pedagogy of the twentieth century in 19201950. Formation of the educational space of Russian emigration, the reasons and factors that influenced its formation. Features of pedagogical views and ideas the most significant scientists and teachers of the Russian abroad (S. Hessen P. Sorokin, E.V. Antipova), which influenced the development of pedagogical ideas in the twentieth century.
РОЛЬ РУССКОЙ ЭМИГРАЦИИ 1920–1930-Х ГОДОВВ СТАНОВЛЕНИИ УНИВЕРСАЛЬНОГО СТАТУСА БЕЖЕНЦЕВ
Authors: Бочарова З.С.
Published: December 2024

Статья посвящена роли эмигрантских организаций в формировании правового статуса российских беженцев. Два этапа законотворчества эмиграции налицо. Первый этап касался выдачи специальных удостоверений личности, известных как паспорта Нансена. Второй связан с усилиями эмигрантских адвокатов по принятию единого правового статуса для российских беженцев. Выделены противоречивые позиции эмигрантов относительно обоснования отказа от российских паспортов и введения новых, без гражданства. Показана как роль Земгора в разработке Свидетельства, так и роль Центральной юридической комиссии по изучению положения российских беженцев в подготовке Соглашения (1928 г.) и последующей Конвенции (1933 г.) о статусе русских и армянских беженцев.

The article states the role of emigre organizations in the development of legal status for Russian refugees. Two stages of emigration lawmaking are clearly in evidence. The first stage dealt with issuing special identity certificates known as Nansen passports. The second saw the efforts of emigrant lawyers to adopt a unified legal status for Russian refugees. Emigrants controversial positions on rationale for rejecting Russian passports and introducing new stateless ones are highlighted. The article shows both the role of Zemgor in elaborating the Certificate, and the role of the Central Legal Commission for the Study of the Situation of Russian Refugees in the preparation of the Agreement (1928) and the subsequent Convention (1933) relating to the status of Russian and Armenian refugees.
КНЯЖНА ЗИНАИДА АЛЕКСЕЕВНА ШАХОВСКАЯ –«СВИДЕТЕЛЬНИЦА ВЕКА»,БЛИСТАТЕЛЬНЫЙ ЛИТЕРАТОР РУССКОГО ЗАРУБЕЖЬЯ
Authors: Володько А.В.
Published: December 2024

Статья посвящена необычайно разносторонней личности: поэту, прозаику, эссеисту, журналисту княжне Зинаиде Алексеевне Шаховской, ее литературной деятельности и неоценимому вкладу в мировую культуру.

The article is devoted to the life of Princess Zinaida A. Shakhovskaya, a person of many talents she was a poet, novelist, essayist and journalist to her creative work, and her invaluable contribution to the global culture.
РУССКИЙ КОНСУЛ, ОРИЕНТАЛИСТСЕРГЕЙ ПЕТРОВИЧ ГОЛУБИНОВ (1879–1951)
Authors: Голубинов В.В.
Published: December 2024

The article discusses a fate of a Russian migr a diplomat, an orientalist, a greatuncle of the author, Sergei Petrovich Goloubinow, whose career as Russian consul in Isfahan (Persia) was interrupted by revolution and civil war. Main milestones in his biography are highlighted. The author traces Sergei Goloubinows service (until the spring of 1920), his path to emigration, and life in France and Germany. The article supplements the materials of conferences People and destinies of the Russian Emigration (2015, 2016, 2017, 2018) and 1917 and the fate of the Russian Emigration (2017), including the biography of S.P. Goloubinows son Vsevolod Goloubinoff (French writer Serge Golon).
ПРОФЕССОР Н.Е. АНДРЕЕВ И ЕГО ВКЛАДВ ИЗУЧЕНИЕ РУССКОЙ ИСТОРИИ И КУЛЬТУРЫ
Authors: Базанов П.Н.
Published: December 2024

В статье реконструируются вехи жизни и основные направления творчества выдающегося историка и литературоведа русской эмиграции Николая Ефремовича Андреев, впервые приводятся уникальные сведения из Бахметевского архива. Особое внимание обращено на исторические и культурологические работы Н.Е. Андреева и его вклад в историю эмиграции. Показано влияние трудов Н.Е. Андреева на современную наука, доказывается, что они являются актуальным историческим знанием.

The article reconstructs the milestones of life and work of an outstanding Russian migr historian and literary critic, Nikolai Efremovich Andreev. Particular attention is drawn to the historical and cultural studies by N.E. Andreev and to his contribution to the history of emigration. The author demonstrates the influence of Andreevs works on contemporary scholarship. It is shown that the works by N.E. Andreev are relevant historical knowledge. The article presents new documents from the Bakhmetev archive.
ФЕВРАЛЬСКИЙ РЕВОЛЮЦИОННЫЙ КРИЗИС 1917 ГОДАВ РЕФЛЕКСИИ ЛИДЕРОВ ПРОГРЕССИВНОГО БЛОКА
Authors: Сараева Е.Л. , Кочешков Г.Н.
Published: December 2024

Статья посвящена анализу идей лидеров Прогрессивного блока в IV Государственной думе о краткосрочных факторах февральского революционного кризиса 1917 г. Прогрессисты считали главным виновником революции власть. По их мнению, бессилие правящей элиты предопределило неизбежность падения монархии. Лидеры Прогрессивного блока выделили краткосрочные факторы Февральской революции: неудачная, непопулярная затяжная война, обрушившая авторитет власти и вызвавшая проблемы в социальноэкономической сфере неспособность правительства эффективно решать задачи государственного управления ориентация монархии на традиционные ценности некомпетентность ряда министров конфликт правительства с Думой социокультурный раскол общества возмущение народа своим бесправием и уровнем жизни, отсутствие хлеба в столице максималистские лозунги радикальных партий, наивное доверие масс к левым агитаторам популярность идеи революции нежелание солдат идти на фронт, власть пыталась, но не смогла использовать силовые методы подавления революции. Прогрессисты интерпретировали исторический процесс в рамках дихотомии традиции новации.

The article is devoted to the analysis of the ideas of the leaders of the Progressive bloc in the IV State Duma of the Russian Empire on the shortterm factors of the 1917 February Revolution. The main culprit of the revolution was the authorities, in the Progressists opinion. The powerlessness of the ruling elite, according to the Progressists, predetermined the inevitability of the fall of the monarchy. Leaders of the Progressive bloc singled out shortterm circumstances that predetermined the February Revolution of 1917: an unsuccessful, unpopular, protracted war that has downed the authority of the government and caused problems in social and economic sphere inability of the government to effectively solve tasks in all branches of public administration orientation of the monarchy on traditional values incompetence of a number of ministers the conflict between the government and the Duma sociocultural division of society indignation of the people with their lack of rights and lowering of living standards, lack of bread in the capital the maximalist slogans of radical parties, the naive confidence of the masses in the leftwing agitators the popularity of the idea of revolution the soldiers unwillingness to go to the front. The authorities tried, but could not use force to suppress the revolution. The Progressists interpreted the historical process within the dichotomy of tradition innovation.
«ЗА МИР ВО ВСЕМ МИРЕ»: ГУМАНИЗМ И ЭТИКА ГЛОБАЛЬНОЙБЕЗОПАСНОСТИ В РАКУРСЕ ИДЕОЛОГИЧЕСКОЙ ПОЛИТИКИ СОВЕТСКОГО РУКОВОДСТВА (1956-1962 ГГ.)
Authors: Шок Н.П. , Пивоваров Н.Ю.
Published: December 2024

Статья посвящена анализу миротворческой политики советского руководства в период, когда СССР постепенно переходит от открытой конфронтации к мирной конкуренции. Основное внимание уделено рассмотрению идей советского руководства в области глобальной безопасности и этики международного диалога. В качестве основных источников привлекаются материалы высших партийных органов ЦК ВКП(б)/КПСС, документы о подготовке и участии представителей СССР в различных миротворческих организациях, переписка советских лидеров с представителями мировых общественных организаций, выдающимися учеными и простыми гражданами иностранных государств, демонстрирующая реакции советского руководства на милитаристические и антигуманные шаги в отношении человечества.

The article is devoted to peacemaking policy of the Soviet leadership during 19561962, the period when the USSR gradually moved from an open confrontation to a peaceful competition. The main attention is paid to the analysis of the ideas of the Soviet leadership in the field of global biosafety and bioethics. The main sources are the materials of the highest party organs the Central Committee of the CPSU(b) / CPSU, including documents on the preparation and participation of representatives of the USSR in various peacekeeping organizations, the correspondence of Soviet leaders with representatives of world public organizations, outstanding scientists, and ordinary people from other countries demonstrating the reaction of the Soviet leadership to militaristic and antihuman measures.
РЕГИОН РОССИИ В КОНТЕКСТЕИНТЕЛЛЕКТУАЛЬНОЙ ИСТОРИИ
Authors: Гелла Т.Н.
Published: December 2024

Рец. на кн.: Непомнящий А.А. Академик С.Ф. Платонов и крымоведение (Белгород: Константа, 2018. 216 с.

Review: Nepomnyashhij А.А. Аkademik S.F.Platonov i krymovedenie. Belgorod: Konstanta, 2018. 216 s. (Seriya: Biobibliografiya krymovedeniya vyp. 27)
ВЕК ПРОСВЕЩЕНИЯ В «QUAESTIO ROSSICA»
Authors: Артамонова Л.М.
Published: December 2024

В статье сделан анализ материалов, опубликованных в новом научном журнале в 20132019 гг. и посвященных эпохе Просвещения в России. Показано, как в этих работах ученыхгуманитариев из различных научных центров России, Франции, Болгарии, Германии, Швейцарии, США было расширено теоретическое, методическое и предметное поле исследования данной эпохи. Выявлена заслуга редколлегии журнала, выходящего в Екатеринбурге, ее высокопрофессиональных и продуманных усилий по созданию авторитетного издания для трудов по истории и культуре России, в т.ч. просвещенного 18го столетия.

The article analyzes the materials published in the new scientific journal in 20132019 and dedicated to the Age of Enlightenment in Russia. It shows how these works by humanities scholars from various scientific centers of Russia, France, Bulgaria, Germany, Switzerland, the USA expanded the theoretical, methodological and substantive field of researching this epoch. It reveals the merit of the journal editorial board in Yekaterinburg with highly professional and thoughtful efforts has created an authoritative periodical for works about the history and the culture of Russia, including the enlightened 18th century.