bluuebunny/crossref_metadata_2025 huggingface dataset:
ALCHEMIST: Adjuvant targeted therapy or immunotherapy for high-risk resected NSCLC.
Authors: Sands Jacob , Mandrekar Sumithra J. , Oxnard Geoffrey R. , Kozono David E. , Hillman Shauna L , Dahlberg Suzanne Eleanor , Sun Zhuoxin , Chaft Jamie E. , Govindan Ramaswamy , Gerber David E. , Gray Jhanelle Elaine , Malik Shakun M. , Mooney Margaret M. , Janne Pasi A. , Vokes Everett E. , Kelly Karen , Ramalingam Suresh S. , Stinchcombe Tom
Published: May 2020

TPS9077

Background: ALCHEMIST (Adjuvant Lung Cancer Enrichment Marker Identification and Sequencing Trial) is a clinical trial platform of the National Cancer Institute that offers biomarker analysis for high-risk resected non-small cell lung cancer (NSCLC) to support randomized trials of novel adjuvant therapies within the National Clinical Trials Network (NCTN). EA5142, a trial of adjuvant nivolumab for patients (pts) without EGFR / ALK alterations, has completed enrollment. Given the survival benefit seen with 1st-line chemo-immunotherapy (chemo-IO) for advanced NSCLC without EGFR / ALK alterations, there was compelling rationale for the launch of a trial offering concurrent immunotherapy with adjuvant chemo. Here we report updated enrollment to ALCHEMIST as of Jan 14, 2020. Methods: ALCHEMIST includes a screening trial (A151216, 5362 registered) that enrolls pts with completely resected clinical stage IB (≥4 cm)–IIIA (per AJCC 7) NSCLC. Tissue and blood are collected, biomarker testing includes EGFR sequencing, ALK FISH and PD-L1 IHC. 733 active sites are enrolling across the NCTN. Pts with EGFR mutations may enroll to adjuvant erlotinib vs observation (A081105, 352 randomized); those with ALK fusions may enroll to adjuvant crizotinib vs observation (E4512, 99 randomized). A trial offering adjuvant nivolumab vs observation regardless of PD-L1 status (EA5142, 935 randomized) recently completed enrollment. To support ongoing investigation of adjuvant immunotherapy, ALCHEMIST is adding A081801 (opens spring 2020). Pts will be randomized to one of 3 arms: chemo-IO with pembrolizumab during and after chemo vs sequential chemo followed by pembrolizumab vs chemo alone. Pts with pathological N2 nodes are eligible and can undergo postoperative radiotherapy after completing chemo. Pts are eligible if enrolled to A151216, negative for EGFR and ALK alterations, and with PD-L1 testing completed (required for stratification). Local testing for EGFR, ALK and PD-L1 will be accepted for enrollment; central testing will not delay randomization. Pts may not have received any therapy except surgery for the lung cancer and must be age >18, Eastern Cooperative Oncology Group performance status 0-1, have no active autoimmune disease requiring systemic treatment within 2 years, must not be pregnant or nursing, have no active second malignancy within 3 years and meet standard organ function values. By building off the ongoing ALCHEMIST platform, we hope to facilitate rapid enrollment to A081801 across participating NCTN sites. Clinical trial information: NCT02194738.
A phase III randomized trial of pleurectomy/decortication plus chemotherapy with or without adjuvant hemithoracic intensity-modulated pleural radiation therapy (IMPRINT) for malignant pleural mesothelioma (MPM) (NRG LU-006).
Authors: Rimner Andreas , Zauderer Marjorie Glass , Yorke Ellen , Simone Charles B. , Gill Ritu R. , Voong K Ranh , Peikert Tobias , Tsao Ming Sound , Li Zuofeng , Rusch Valerie W. , Bradley Jeffrey
Published: May 2020

TPS9079

Background: Pleurectomy/Decortication (P/D) with neoadjuvant or adjuvant chemotherapy has become a common lung-sparing surgical approach for MPM. Adjuvant hemithoracic IMPRINT was developed at Memorial Sloan Kettering Cancer Center and safe in a multi-institutional phase II study, with promising survival outcomes. The National Cancer Institute (NCI) sponsored this phase III randomized cooperative group trial to test the efficacy of this lung-sparing trimodality approach for resectable MPM. Methods: Patients with newly diagnosed MPM amenable to P/D are enrolled and undergo P/D followed by adjuvant platinum/pemetrexed (preferred) or neoadjuvant chemotherapy followed by P/D. Patients are stratified by histologic subtype, resection status (R0/1 vs. R2), and center patient volume (≤10 vs. > 10 P/Ds per year). Within 8 weeks after completion of the second modality patients are randomized 1:1 to undergo hemithoracic IMPRINT vs. no further therapy. All IMPRINT contours and treatment plans will be centrally reviewed. A contouring atlas and treatment planning constraints for target structures and organs at risk including acceptable and unacceptable variations and deviations were developed. Photon and proton therapy are permitted. The primary endpoint of the study is overall survival. Secondary endpoints include local failure-free, distant-metastases-free and progression-free survival, treatment-related toxicities (CTCAE v5.0) and change in quality-of-life (EORTC QLQ-C30 mean score changes at 9 months post randomization). The target accrual is 150 patients. This study was activated on January 29, 2020. Over 20 institutions have already committed to opening the study which is open to all National Clinical Trials Network (NCTN) sites. Treatment planning guidelines and helpful hints for photon and proton therapy will be presented. Conclusions: NRG LU-006 (clinicaltrials.gov: NCT04158141 ) is open to accrual. This is the first NRG Oncology randomized phase III trial on MPM and evaluates the use of IMPRINT following lung-sparing P/D and chemotherapy. This project was supported by grants U10CA180868 (NRG Oncology Operations), U10CA180822 (NRG Oncology SDMC), U24CA180803 (IROC) from the National Cancer Institute (NCI). Clinical trial information: NCT04158141.
NRG Oncology/Alliance LU005: A phase II/III randomized clinical trial of chemoradiation versus chemoradiation plus atezolizumab in limited stage small cell lung cancer.
Authors: Ross Helen J. , Hu Chen , Higgins Kristin Ann , Jabbour Salma K. , Kozono David E. , Owonikoko Taofeek Kunle , Movsas Benjamin , Solberg Timothy , Xiao Canhua , Williams Terence Marques , Welsh James William , Simko Jeffry , Wang Xiaofei F. , Mohindra Nisha Anjali , Hsu Charles , Stinchcombe Tom , Bradley Jeffrey
Published: May 2020

TPS9082

Background: Limited stage small cell lung cancer (LS-SCLC) is treated with standard of care platinum/etoposide (EP) and thoracic radiation therapy (TRT) with curative intent, however the majority of patients are not cured and median overall survival is approximately 30 months. Addition of atezolizumab to chemotherapy in extensive stage SCLC has improved progression free and overall survival in a non-curative setting leading to hope that addition of an immune checkpoint inhibitor to standard chemoradiotherapy could benefit LS-SCLC patients. LU005 is a randomized phase II/III trial of standard concurrent chemoradiation with or without atezolizumab for patients with LS-SCLC. Methods: Patients are randomly assigned in a 1:1 ratio to standard EP chemotherapy with concurrent TRT (45 Gy BID or 66 Gy QD) with or without atezolizumab beginning concurrently with TRT, and continued every 3 weeks for up to 12 months. Eligible patients have LS-SCLC, PS 0-2, adequate organ function, no concerning comorbidities (including no active autoimmune disease) and are eligible for TRT. Patients are randomized prior to their second cycle of EP and thoracic radiation begins with the second overall cycle of chemotherapy (first cycle of study therapy) in both treatment arms. Prophylactic cranial radiation (PCI) is recommended for patients who respond to treatment. The phase II/III primary endpoints are progression free (PFS) and overall survival (OS) respectively. Secondary endpoints include objective response rates, local and distant disease control, and quality of life/patient reported outcomes assessment. Translational science component includes blood and tissue based immune related assays. This study activated in May 2019. 50 of 506 planned patients have been accrued as of 2/1/2020. Supported by grants U10CA180868 (NRG Oncology Operations), U10CA180822 (NRG Oncology SDMC), U23CA180803 (IROC) from the National Cancer Institute (NCI) and Genentech. *Authors Ross and Higgins are co-first authors and contributed equally to this work. Clinical trial information: NCT03811002.
Phase II randomized trial of carboplatin + pemetrexed + bevacizumab, +/- atezolizumab in stage IV non-squamous non-small lung cancer (NSCLC) patients who harbor a sensitizing EGFR mutation or have never smoked.
Authors: Bodor Joseph Nicholas , Patel Jyoti D. , Ross Eric A. , Litwin Samuel , Clapper Margie , Levy Benjamin Philip , Wakelee Heather A. , Borghaei Hossein , Treat Joseph
Published: May 2020

TPS9629

Background: Stage IV NSCLC patients who are never-smokers or with EGFR-mutated tumors generally do not benefit from single-agent immunotherapy. Retrospective subgroup analyses from recent phase III trials suggest that immunotherapy-chemotherapy +/- VEGF inhibition may overcome resistance to PD-L1 inhibitors in these patients, however prospective research on this is needed. This trial will examine a patient population with stage IV non-squamous disease who either have tumors that possess an EGFR exon 19 or 21 mutation or who are never-smoker wild-types, to determine whether the PD-L1 inhibitor atezolizumab in combination with pemetrexed, carboplatin, and bevacizumab can improve outcomes. Methods: This is a randomized, phase II, multi-center, open-label trial to assess pemetrexed/carboplatin and bevacizumab +/- atezolizumab in 117 subjects with stage IV non-squamous NSCLC. Randomization will be 2:1 favoring the + atezolizumab arm. Patients are stratified by EGFR mutation status (i.e. EGFR exon 19 or 21 vs. never-smoker wild-type). Never-smoker wild-type is defined as smoking < 100 cigarettes in a lifetime and without any EGFR mutation or ALK or ROS1 rearrangement. Patients with EGFR exon 19 or 21 mutated tumors must have progression of disease or intolerance of treatment with one or more prior TKIs. Primary endpoint is progression-free survival (PFS). Secondary endpoints include overall survival (OS), overall response rate, duration of response, and time to response. Primary objective is to compare PFS between arms. Secondary objectives include a safety analysis in all treated subjects, and comparisons of PFS and OS between arms for the patient subset with EGFR-mutated tumors. Correlative studies include interrogating flow cytometry-based peripheral blood biomarkers, examining the role of desmoplasia in local tumor immunosuppression, and assessing the contribution of estrogen metabolites to tumorigenesis. This study opened in August 2019 with 2 patients enrolled at the time of submission. Twenty U.S. sites through the NCCN are participating. This study was approved and funded by the National Comprehensive Cancer Network (NCCN) Oncology Research Program from general research support provided by Genentech, Inc. Clinical trial information: NCT03786692 .
A phase III, open-label, randomized study of atezolizumab in combination with carboplatin + paclitaxel + bevacizumab compared with pemetrexed + cisplatin or carboplatin with stage IV non-squamous non-small cell lung cancer (NSCLC) with activating EGFR mutation or ALK translocation (ATLAS Trial).
Authors: Park Sehhoon , Lee Yun-Gyoo , Park Ji Hyun , Lee Gyeong-Won , Kang Eun Joo , Choi Yoon Ji , Shin SeongHoon , Han Ji-Youn , Lee Suee , Kim YuJung , Kim Tae Min , Kim Sang-We , Shim Byoung Yong , Cho Jinhyun , Kim Hye Sook , Park Sang Gon , Lee Ki Hyeong , Kim Ilhwan , Ahn Myung-Ju
Published: May 2020

TPS9636

Background: In patients with activating EGFR mutations and ALK fusion, target specific tyrosine kinase inhibitor (TKI) showed significant survival improvement compared to the cytotoxic chemotherapy. However, the questions remain which combination strategy will be the best option for the patients who have failed from TKI. Especially, the role of an immune checkpoint inhibitor (ICI) in this population is still unclear. This study is designed and conducted based on the recent subgroup analyses from the IMpower 150 study which showed the positive clinical outcomes of atezolizumab combined with VEGF inhibitor and conventional cytotoxic chemotherapy in EGFR mutation and ALK translocation. Methods: This study is the phase III, open-label, multicenter study of atezolizumab in combination with bevacizumab + carboplatin + paclitaxel (ABCP, Arm A) compared with pemetrexed + cisplatin or carboplatin (Arm B). The study population will be randomized to either Arm A (n = 152) or Arm B (n = 72) based on two stratification factors, EGFR vs. ALK and presence of brain metastases. In Arm A, patients will be treated with 4 or 6 cycles of ABCP followed by maintenance atezolizumab and bevacizumab every three weeks. In Arm B, pemetrexed maintenance therapy will be applied every three weeks after 4 or 6 cycles of pemetrexed + cisplatin or carboplatin. As key inclusion criteria, the patients must be diagnosed with stage IV non-squamous non-small cell lung cancer with either activating EGFR mutation or ALK translocation. All the patients need to be cytotoxic chemotherapy naïve and must have experienced disease progression to treatment with at least one EGFR or ALK TKI. If the patients have T790M mutation after 1st or 2nd generation EGFR TKI, second line 3rd generation EGFR TKI treatment is mandatory. The number of T790M positive patients is restricted to under 30% of the entire study population. The primary endpoint is progression-free survival and the major secondary endpoints are overall survival, objective response rate and duration of response. A total of 228 subjects will be enrolled to detect a hazard ratio of 0.67. The first subject received treatment in Aug. 2019 and 19 patients receive the treatment. This study is opened in 3 sites and expected to be opened at 18 sites in South Korea. The time point for the primary analyses is Q3. 2022. Clinical trial information: NCT03991403 .
In Vitro Control of Genes Critical for Parathyroid Embryogenesis by Extracellular Calcium
Authors: Fabbri Sergio , Zonefrati Roberto , Galli Gianna , Gronchi Giorgio , Perigli Giuliano , Borrelli Andrea , Brandi Maria Luisa
Published: May 2020

Background

The expression of the parathyroid transcription factors, encoded by the genes GATA3, GCM2, and MAFB, persists after parathyroid morphogenesis. This suggests a role of these genes in the regulatory program that governs parathyroid function in the adult. Indeed, these 3 genes form a transcriptional cascade able to activate PTH gene expression.

Materials and Methods

Adult adenoma parathyroid tissues were put in primary cell culture to evaluate the messenger ribonucleic acid (mRNA) expression of the PTH gene, of the genes involved in the calcium regulatory signaling pathway (CaSR, GNA11, and AP2S1), and of the 3 genes (GATA3, GCM2, and MAFB) involved in the parathyroid morphogenesis in the presence of different extracellular calcium concentrations from 0.1 mM to 3.0 mM.

Aim

The aim of the study was to investigate whether different extracellular calcium conditions could control the expression of transcription factors critical for parathyroid embryogenesis.

Results

The results of the experiments showed that the mRNA expression of GATA3, GCM2, and MAFB genes follows the same response as the PTH gene to extracellular calcium concentrations, with the highest expression at low calcium (0.1 mM) and the lowest at high calcium (3.0 mM). Conversely, the genes involved in the calcium signaling in the parathyroid cells showed a variable response to the extracellular calcium concentrations, with the CaSR and GNA11 genes exhibiting a sensitivity to low calcium concentrations.

Conclusions

These findings indicate that transcription factors recognized for their role in parathyroid embryogenesis show a response to extracellular calcium later in adulthood that parallels the behavior of the PTH gene.
ORGANIZAÇÃO TERRITORIAL E METRÓPOLES SECUNDÁRIAS NO BRASIL E ARGENTINA (CURITIBA/BR E TUCUMÁN/AR)
Authors: Carmo Julio Cesar Botega
Published: May 2020

Busca-se caracterizar e relacionar a organização das federações brasileira e argentina, destacando as funções institucionais, o poder político sobre o território e os reflexos de tal cenário na organização das redes urbanas de cada país. Na sequência, se apresenta um estudo de caso, destacando a organização e qualificação das metrópoles secundárias, enquanto centros de articulação econômica e territorial, de relevância em seus contextos nacionais, particularizado no estudo analítico e comparativo entre as cidades de Curitiba (BR) e Tucumán (AR), apresentando por fim, características das metrópoles secundárias e a relevância do conhecimento sobre as cidades nesta categoria.
An alternative placement model for nursing students: discovering new horizons
Authors: Humphries Belinda , Keeley Sarah , Stainer Lucy , Watson Amanda
Published: May 2020

This article explores the use of an alternative placement model in conjunction with the Nursing and Midwifery Council standards for education and training. Traditionally in nurse education, students were supported on placement on a one-to-one basis by a qualified nurse mentor. This could be a very intense relationship and could limit placement learning as students were only allocated to areas that have a qualified nurse mentor, exacerbating competing demands on placement capacity to support students. A higher education institute trialled an alternative placement model that used several healthcare-related services traditionally not used for nursing placements. Some of these placements were allocated by the higher education institute, but students were also responsible for securing a number of placements for themselves. The students were supported with their learning by appropriate healthcare staff in practice but were assessed by academic members of staff at the higher education institute acting as practice assessors. The project was evaluated positively overall by the vast majority of students and staff. Students found it to be an empowering experience, which encouraged autonomous practice.
The importance and cost-effectiveness of the MenB vaccine within healthcare services
Authors: Harris Gemma
Published: May 2020

Gemma Harris looks at new evidence that survival rates of meningococcal B – one of the most common causes of meningococcal meningitis – are increasing, and discusses what needs to be done to improve this further and the cost-effectiveness of current treatment for the NHS.
French hospitals faced with the COVID-19 pandemic: the reality of logistical strategies
Authors: Paché Gilles
Published: May 2020

The COVID-19 pandemic has challenged many health systems, particularly in France, Italy and Spain. The very sharp increase in the number of patients with acute respiratory distress syndrome led public hospitals to implement management-inspired logistical strategies. This comment focuses on the French system and underlines that hospitals tend to be increasingly managed like private companies.
Support for our health workers
Authors: Moffat Polly
Published: May 2020

A new report warns the country's healthcare workforce will face significant health, mental health and welfare challenges unless action is taken now
Does meloxicam provide adequate pain management as a post-operative analgesic in canine ovariohysterectomy patients?
Authors: Goldsbrough Gavin , Reynolds Helen
Published: May 2020

Background:

Meloxicam is an analgesic agent with anti-inflammatory properties, commonly used in veterinary practices to treat a variety of different long-term medical conditions and is also used as a short-term pain relief following particularly traumatic surgeries.

Aims:

An observational study was conducted to determine whether meloxicam provides adequate pain management as a post-operative analgesic for canine ovariohysterectomies.

Methods:

13 canines were admitted for ovariohysterectomy. Each patient was assessed using the Glasgow composite pain scale (CMPS) prior to surgery during the admission procedure, 15 minutes post-operatively, at discharge and at their post-operative check (POC) 3–5 days after surgery.

Results:

Data were statistically analysed to determine the overall effectiveness of meloxicam in reducing pain following canine ovariohysterectomy. The results showed a statistically significant difference (Kruskal-Wallis test: H3 =12.98, p=0.005) in pain scores between admission, 15 minutes post operatively, discharge and 3–5 days POC. The greatest decrease in pain score was between 15 minutes post-operatively and POC (Mann-Whitney U test: W=236, n=13, 13, p=0.0014) and between discharge and POC (Mann-Whitney U test: W=227, n=13, 13, p=0.0060). Overall, this demonstrated that there was an improvement in pain suggesting meloxicam is effective between these time frames. In addition, 69.2% (n=9) of patients in the study showed a pain score of 0, indicating an absence of pain, on their final POC. Statistical analysis was also used to determine if there was any difference in pain score between the 3, 4 or 5 day POC pain score. The results show there was no significant difference (Kruskal-Wallis test: H2 =0.090, p=0.638) suggesting that meloxicam's effectiveness was similar across this range of time post surgery.

Conclusion:

The results from the study indicate that meloxicam is an effective post-operative analgesic for canine patients undergoing an ovariohysterectomy.
Spring parasite update 2020
Authors: Stokes Laura , Wright Ian
Published: May 2020

While COVID-19 is impacting all of us, the veterinary profession continue to do an amazing job of continuing pet health care while keeping risk to staff and clients to a minimum. During the crisis, parasite control remains a vital part of maintaining animal health, and ESCCAP UK and Ireland continues to help disseminate the latest evidence-based parasite control advice by email, phone, website and CPD platforms to keep pets healthy and to guard against zoonotic risk. This article will provide a brief overview of some of the current parasite hot topics and threats to the UK, taking information from the quarterly Parasite Forecast published on the ESCCAP UK and Ireland website: www.esccapuk.org.uk .
Arxius personals de dones durant la dictadura: aproximació als fons documentals del Museo de la Memoria y los Derechos Humanos de Xile.
Authors: Ortiz María Luisa , Bernasconi Oriana , Lagos Tamara
Published: May 2020

Objective: To identify, describe and analyse the narratives present in the documents donated by women to Chile’s Museum of Memory and Human Rights (MMDH).

Methodology: A mixed-method exploratory study which presents a descriptive statistical analysis of the collection of documents donated to the MMDH, according to the person making the donation and the genre; an analysis of the profile, rationale, origin and type of experience described in order to propose a classification; and the analysis of 37 documents selected in order to illustrate this classification.

Results: Despite the severe restrictions imposed on political activity, association, and public discourse, and the profound damage that state terrorism inflicted on the social fabric, the personal documents of women bear witness to their fundamental role in the defence and promotion of human rights, as well as in the political, social and cultural mobilization against the dictatorship of Chile.
Light-induced thermo-elastic effect in quartz tuning forks exploited as a photodetector in gas absorption spectroscopy
Authors: Russo Stefano Dello , Zifarelli Andrea , Patimisco Pietro , Sampaolo Angelo , Wei Tingting , Wu Hongpeng , Dong Lei , Spagnolo Vincenzo
Published: May 2020

We report on a study of light-induced thermo-elastic effects occurring in quartz tuning forks (QTFs) when exploited as near-infrared light detectors in a tunable diode laser absorption spectroscopy sensor setup. Our analysis showed that when the residual laser beam transmitted by the absorption cell is focused on the QTF surface area where the maximum strain field occurs, the QTF signal-to-noise ratio (SNR) is proportional to the strain itself and to the QTF accumulation time. The SNR was also evaluated when the pressure surrounding the QTF was lowered from 700 Torr to 5 Torr, resulting in an enhancement factor of ∽4 at the lowest pressure. At 5 torr, the QTF employed as light detector showed an SNR ∽6.5 times higher than that obtained by using a commercially available amplified photodetector.
Double-ring interference of binary diffractive axicons
Authors: Sánchez-López María M. , Moreno Ignacio , Davis Jeffrey A. , Gutierrez Benjamin K. , Cottrell Don M.
Published: May 2020

We report on the interference between the double rings generated by the Fourier transform of a binary diffractive axicon. These two rings have the same size and correspond to the ± 1 diffracted order beams. The interference condition between both rings can be easily changed by adding a constant phase bias, resulting in a central ring that is either dark or bright. Additionally, this interference condition can be changed along the ring and can be easily tuned, thus allowing greater flexibility. We present experimental results obtained with a binary π-phase liquid-crystal spatial light modulator. These patterns might find applications in optical trapping systems, where the bright or dark regions could trap particles whose refractive index is either higher or lower than the medium.
Sustainable retail system: Proposal for closed-loop fashion
Authors: Palomo-Lovinski Noël
Published: May 2020

Abstract The fashion industry is at a turning point due to the increased unsustainability of current economic, environmental and social practices requiring a new set of best practices throughout the supply and value chains. Retailers and manufacturers seek profit in a consumer
market that increasingly expects more product and services for less money at a quicker rate of turnover. Scarcity of resources, from natural materials to affordable labour, will only intensify rather than be ameliorated in the current system. Concurrently, increasing awareness of environmental
and social harm will make negotiations between price and availability all the more acute. The consumer expectation of environmentally friendly practices does not necessarily translate into acceptance of higher costs in the marketplace. The fashion industry therefore must reconsider the role
of the designer, the use of technology, long-term responsibility for all products sold and how to engage the consumer beyond the confines of the traditional point of sale. Designers, manufacturers and retailers will have to reconfigure the supply chain process and expand the possibilities
of experiential retail to accommodate increased consumer demand of getting what they want when they want it, all while affording confidence and trust. This article is a proposal for a Closed-Loop Sustainable Product Service System and Retail construct. The proposal suggests a national network
of design, retail and manufacturing sites specific to a community or region. Specific technology would support small batch production geared to the requirements of a community or locality while taking responsibility for all waste. A supporting literature review will be provided reinforcing
the assertions and suggestions made by the author.
Setting the scene for slow fashion: Digital explorations of New York's fibrescape
Authors: Trejo Helen X. , Lewis Tasha L. , Arellanes David E.
Published: May 2020

Abstract Farmers with sheep, alpacas and goats provide opportunities for local slow fashion. This is a practice-based case study that developed after discovering primary issues experienced by New York fibre farmers such as low profits and difficulty reaching a market. Beyond
products available, farmers highlighted the educational value of their farms, animals and fibres, which are intangible aspects of slow fashion. The aim of this research is to increase the visibility of New York farms, natural fibres and opportunities for slow fashion through digital media
short films. This research was guided by Actor Network Theory and the cartography of controversies method during broader slow fashion research in 2013 through 2017. The four New York farm-to-fashion films highlight fibre agro-tourism, artisanship, locally produced fashion and sorting raw fibres
for scaled production. The process of creating the short films and interacting with farmers made several entities within the local farm-to-fashion network more visible, including limited access to communication technologies in rural areas, water issues, the closure of fibre mills and economic
development issues. The 'collective existence' of local farm-to-fashion is complex and includes social, economic, political and environmental elements in addition to previously considered entities such as fibre animals, farmers, infrastructure and tools. The films were presented to several
academic, community audiences and are available as open resources.
Communicating identity through wearable technologies: The case of the action film
Authors: Stankevičiūtė Kristina
Published: May 2020

Abstract The wearable technologies market claims to be growing continually, and yet the question if wearables have actually assumed an indispensable place in fashion and mass consumerism remains. Apart from a number of practical problems such as high price, poor design and
numerous reservations over privacy, wearable technologies also seem to give rise to identity issues. Leaning on research conducted by Natalia Berger of Inholland University (the Netherlands) on mass media texts and the manner in which they communicate the idea of smart fashion/wearable technologies
to the mass consumer, the article attempts to look at the field of action film and the message that this specific genre communicates to its audiences about wearables. The argumentation focuses on the issue of identity and how wearable technologies participate in its creation within the realms
of real life and the fictional reality of action film. The findings of the discussion concur with those of Berger, i.e. that, to enhance the popularity of wearable technologies and devices in real life, action films, like other mass media, must apply an inclusion policy, rather than communicating
them as a niche market for minorities, such as a special, elitist group like government agents or superheroes. Following recommendations from experts and enthusiasts in the field, the article suggests that wearable devices be communicated as empowering their users in everyday life.
A magyar egyetem-irányítás reformkísérlete
Authors: Keczer Gabriella
Published: May 2020

After the change of the political system in 1990, the management system of Hungarian universities was settled by the 1993 law of Higher Education. But the necessity of a new reform was suggested right at the beginning. Finally it was initiated by the liberal educational government in 2002. Experts suggested the introduction of the aglo-saxon model of university governance with the board-system, and this concept was int he core of a new bill. But during the social debate of the bill, the oroginal concept was significantly softened. But even the softened version failed at Constitutional Court. In my paper I summarize the process of the reform, and evaluate it ont he basis of the outcomes of 10 interviews conducted with rectors and deans of Hungarian universities. Finally I give some suggestions to be taken into considetarion when initiating another reform of university management.
A magyar kormányok konvergencia programjai a választási ciklusok szorításában
Authors: Gősi János
Published: May 2020

Hungarian convergency programmes are trapped in the four-year political cycles. The logic of the parliamentary elections - because of the danger of failure - let fiscal restrictions to be implemented only in the first two years. This is extremely true for general structural reforms, from what the public and the political parties longing for victory expect serious results after 2-3 years of hardship.
Klaszter-analízis a baromfihús-termékek piacán
Authors: Vincze-Lendvai Edina
Published: May 2020

The products of the poultry species play a more important role in the supply with food of the population of Earth. In our research we made a representative 1000-persons- questionnaire fact-finding. We wanted to take the measure of consumers' attitudes about processed poultry products.  After the apprehension of the answers we made factor- and cluster-analysis. The 97,6 percents of the poultry-products consumers was divided into 7 factors and 4 clusters respectively by the factor- and cluster-analysis based on the life-style, the demography and the attitudes. The most substantial factor is the price for the members of the "A" cluster, and the quality for the people of the "B". Persons belong to "C" cluster like the branded, convenience products, and the moneyless pensioners from "D" think the most important factor is the price.
Az ISO 9000 szabványok változásai
Authors: Marosi Tibor
Published: May 2020

The International Organization for Standardization issued the new ISO 9001:2008 standard with title Quality Management systems. Requirements at 15 Nov 2008. In spite of arrangements lasting more years the requirements of the standard basically have not changed. The main goal of changes was in one hand the more understandable and clearer text, on the other the increasing compatibility with the standard ISO 14001. This paper gives an explanation of changes in requirements ISO 9001:2008. These changes have been taken into consideration by the users if they want to suit the expectations of the new document.
Trust, culture, and territorial development
Authors: Kis Mária
Published: May 2020

Some researchers think that economic life is inseparable from culture, i.e., the "irrational" values associated with moral, public spirit, family, and religion, thus the latter manifests itself in neo-liberal economics that predominantly relies on interests and making rational choices only to a limited extent. Therefore, modern societies see preservation or creation of high-level social trust and social capital as their major task, since its lack is capable of hindering economic growth in a way similar to that of a deficit in physical capital. The above considerations provide a ground for explaining the success of certain settlements and the failure of others to succeed.
Az élelmiszer-önrendelkezés koncepciója és magyarországi realitásai
Authors: Czagány László
Published: May 2020

A globalizáció és neoliberális gyökerű nemzetközi szabad kereskedelem káros hatásai ellen fellépő mozgalmak az elmúlt néhány évben egyre hangsúlyosabban kommunikálják az élelmiszer-önrendelkezés paradigmáját. Ehhez képest a szélesebb közérdeklődés alig-alig fogta a szenvedélyes üzeneteket, szakmai körökben pedig inkább az új paradigma korlátait hangsúlyozzák, sokkal kevésbé kutatják a gyakorlati alkalmazás lehetőségeit.
Információelmélet és marketing
Authors: Kis Mária
Published: May 2020

In the lat analysis the informationtheory puts the matter in another light the questionaris and those results. In analysis it is possible use arithmetic of informationtheory and those show to interesting connections , but these prove insufficient for itself. It is necessary completing the quantitative analyses of information with qualitative analyses.
Egy dél-békési település, Mezőhegyes víz- és csatornaellátottságának vizsgálata 1990 és 2006 között
Authors: Zsótér Brigitta
Published: May 2020

The aim of the research was to find answer to the following question: did a small town (Mezőhegyes) in the southern part of County Békés manage to keep up with the other towns of the county in terms of sewerage in the period between 1990 and 2006? Regarding the length of the sewerage per one km of the public water network Mezőhegyes has never belonged to the towns with the best sewerage. It was the 12th on the list of twelve towns in 1990, the 7th on the list of seventeen in 2001, and in 2006 it was the 11th in the rank of eighteen towns. Considering the data of the sewerage it can be ascertained that Mező-hegyes could not reach even the average level of the towns in Békés from this point of view.
Students' responses to teacher's requests in 'CraftEng'
Authors: Gál József , Vanderstein Noémi
Published: May 2020

In our running world, Teaching English as a Foreign Language for beginners is a crucial point of education. To motivate young learners is essential in life-long-leaming so it is important to find the best way of introducing foreign languages for children. The teachers have a number of methods and approaches in their hands to choose from in order to produce as many effective language users as possible. During the lessons - next to questions -, teachers use commands and requests to get the students to respond and to react to them. What is more, creative activities and games are popular among students. Schools work by different tactics to invite more and more learners to acquire second language in their institutions. 'CraftEng' is one of the new trends.
A LEADER-megközelítés helye és szerepe a vidékfejlesztési politika megvalósításában
Authors: Kis Krisztián , Szekeresné Köteles Rita
Published: May 2020

The LEADER approach as a sustainable development streamline based on local resources, means a paradigm of competitive and sustainable rural development. The Local Action Groups (LAGs) as local development organizations forming in the framework for applying the concept of LEADER method, have an important role in realization of objectives of the rural development policy at local level. The execution of the rural development policy can be interpreted as the fulfillment of levels building on each other in an objectiveinstrument type of implementation, which is pervaded by the LEADER approach. The LEADER is not only a successful way of rural development, but a concept or a model that pervades and embraces the whole process of programming and execution of rural development from the policy level to the implementation of projects.
“Obedezco pero no cumplo”: Surviving Censorship in Early Modern Spain
Authors: Adorno Rolena
Published: May 2020

Better known by the royal decrees that governed it than by its practice, book censorship in Early Modern Spain remains an elusive topic. How did it work in individual instances? Were there authors who defied it? I take up here two works, one an imprint published and expurgated; the other a manuscript, approved for printing but never published. Both reveal the marks of the censor’s pen (occasionally, knife) but also the literary personalities of the authors whose writings were scrutinized. Both works belong to the genre of “proto-anthropology” that studied civilizations ancient and modern, from the Old World and the New. Please meet Fray Jerónimo Román y Zamora and his Repúblicas del mundo [Republics of the World] and Fray Martín de Murúa, author of Historia General del Piru [General History of Peru]. Along the way we encounter their respective readers, “Dr. Odriozola” and Fray Alonso Remón, as well as the larger-than-life presence of Fray Bartolomé de las Casas.
Determination of the content of selected trace elements in Polish commercial fruit juices and health risk assessment
Authors: Kowalska Grażyna , Pankiewicz Urszula , Kowalski Radosław , Mazurek Artur
Published: May 2020

The objective of the study was to determine the content of cadmium (Cd), lead (Pb),
arsenic (As), aluminium (Al), thallium (Tl), antimony (Sb) and uranium (U) in the
apple and orange juices and black currant nectar in relation to the kind of
packaging. Also, probabilistic risk assessment (non-carcinogenic) was estimated by
models including target hazard quotient (THQ and THQ*). Aluminium (Al) was present at
the highest concentration in the analysed juices and nectars, with average
concentration ranging from 1.34 mg/kg in orange juices (glass) to
4.26 mg/kg in black currant nectar (glass). Fruit juices and nectars kept in
tetra pack packaging were characterised by elevated concentrations of Al and Sb,
while the products in glass packaging contained significantly higher concentrations
of As compared with the products in tetra pack packaging. Although the average
concentrations of trace elements were lower than the standard limit, exposure to
non-carcinogenic factors was demonstrated.
Failure to Meet up to Expectation: Examining Women’s Activist Groups in the Post-Colonial Period in Nigeria
Authors: Dagunduro Adebukola , Adenugba Adebimpe
Published: May 2020

Women’s activism within various ethnic groups in Nigeria dates back to the pre-colonial era, with notable heroic leaders, like Moremi of Ife, Amina of Zaria, Emotan of Benin, Funmilayo Kuti, Margaret Ekpo and many others. The participation of Nigerian women in the Beijing Conference of 1995 led to a stronger voice for women in the political landscape. Several women’s rights groups have sprung up in the country over the years. Notable among them are the Federation of Nigerian Women’s Societies (FNWS), Women in Nigeria (WIN), Kudirat Initiative for Democracy (KIND) and Female in Nigeria (FIN). However, majority have failed to actualize significant political, social or economic growth. This paper examines the challenges and factors leading to their inability to live up to people’s expectations. Guided by patriarchy and liberal feminism theories, this paper utilizes both historical and descriptive methods to examine these factors. The paper argues that a lack of solidarity among women’s groups, financial constraints, unfavourable political and social practices led to the inability of women’s groups in Nigeria to live up to the envisaged expectations. The paper concludes that, for women’s activist groups to survive in Nigeria, a quiet but significant social revolution is necessary among women. Government should also formulate and implement policies that will empower women politically, economically and socially.
Categories in Stromata VIII
Authors: Havrda Matyáš
Published: May 2020

The article is an analysis of a chapter dealing with the Aristotelian categories in the so-called eighth book of Stromata by Clement of Alexandria, a collection of notes from a philosophical source (or sources) concerned with the theory of demonstration and related issues. Though seldom mentioned in contemporary scholarship, this short chapter is a valuable testimony of the reception of the Categories in the philosophy of the Imperial period and before the time of Alexander of Aphrodisias. After a brief survey of its contents, the article investigates parallels in philosophical literature and explores the function of the chapter within the larger context of Stromata VIII. In the final section the question of Clement's source is addressed. Drawing on earlier research concerning other parts of the eighth book, the article argues that in this case, too, Galen's lost writing on demonstration is a likely candidate.
Empedocles' "Mountain Path'' (fr. 24)
Authors: O'Brien Denis
Published: May 2020

Empedocles' fr. 24 is known only from its quotation by Plutarch. The words as quoted leave themselves open to divergent interpretations. The context in Plutarch nonetheless holds out some hope of being able to decide which of the divergent interpretations would have matched the use that Empedocles himself made of the two verses in his poem.
Le cause della fortuna: un'aporia. Aristotele, Fisica B 5.197a20-25
Authors: Masi Francesca Guadalupe
Published: May 2020

In this paper I will examine a difficulty (aporia), which Aristotle raises in Physics B 5.197a20-25: whether fortuitous things can be held as causes of luck. I will show the meaning of the passage and its relevance within the context of Aristotelian extended analysis of the notions of ``luck'' and ``chance''. I will claim that, in facing the problem, Aristotle has a twofold aim. Firstly, he wants to explain why luck is, after having enquired whether it exists and what it is. Secondly, he wants to prevent his pupils, among others, from denying causal efficacy to luck, by reducing fortuitous events, that are the result of accidental causes, to the action of per se causes, such as nature and human deliberation.
Il ruolo della retorica tra democrazia e oligarchia. Un’ipotesi di attribuzione di un supposto frammento socratico
Authors: Vassallo Christian
Published: May 2020

Since the editio princeps, PSI XI 1215 has been recognized as a fragment of a Socratic dialogue. After the first studies on its philological aspects and probable authorship, however, the text has not drawn the attention of historians of ancient philosophy, and this important Socratic evidence has long been totally neglected. This paper reviews the history of scholarship on the Florentine fragment and presents a new critical edition, on the basis of which it tries to give for the first time a historico-philosophical reading of the text. This interpretation aims to demonstrate: a) that the Socratic philosopher who is writing had not a low cultural level, and the fragment presupposes an accurate knowledge of Plato’s political thought, as Medea Norsa and Girolamo Vitelli already supposed with regard to Book 8 of Plato’s Republic; b) that the fragment in question can be attributed to a Socratic dialogue which was most likely composed in the first half of the 4th century BC; c) that both philosophical and textual arguments support the attribution of the fragment to a dialogue of Antisthenes.
Due passi sull’origine della materia in Giamblico. Note a margine
Authors: Taormina Daniela Patrizia
Published: May 2020

Iamblichus took a clear stand in the late-antique debate on the origin of matter: in his view, matter is generated, in the sense that it is brought about by a higher principle (primary causes) outside physical time. Two passages testify to this conception: In Tim. fr. 38 Dillon (= Procl. In Tim. I, p. 386.8-13 D.) and Ad Porph. (De myst.) p. 196.14-19 Saffrey-Segonds (= VIII3, p. 265.6-10 Parthey). The relation between the two, however, is rather problematic and scholars stand divided: some maintain that Proclus drew the conception expounded in In Tim. fr. 38 from Iamblichus’ commentary by the same title, others that he drew it from Ad Porph. The question is a far from marginal one. It is connected to the problem of the attribution of Ad Porph. and strongly bears upon the issues of Iamblichus’ work method and of his doctrine. Moreover, the very reconstruction of the text of Ad Porph. closely depends on how the analogy connecting it to In Tim. fr. 38 is understood. A reading of the two passages, first each in its own context and then in the light of one another, reveals that In Tim. fr. 38 is based on the lost commentary on the Timeaeus. Consequently, the two passages are seen to adopt a reverse perspective on the subject, so to speak: In Tim. fr. 38 elucidates Plato through Hermes, while Ad Porph. elucidates Hermes by introducing Platonic notions. Finally, with regard to Ad Porph. p. 196.14-19, a suggestion is made to retain the transmitted text.
Non si dimostra il vero: la critica di Sesto Empirico ai procedimenti apodittici
Authors: Spinelli Emidio
Published: May 2020

Thanks to a careful reading of a key passage in Sextus Empiricus’s Outlines of Pyrrhonism (PH II 134-170), this paper offers a sort of running commentary that makes clear some crucial aspects of the Pyrrhonian attack against any kind of subsistence or ὑπόστασις of the ἀπόδειξις. This notion (fundamental for the dogmatic approach to epistemological topics) will be examined in its main logical guidelines as well as in some of its historical declinations, especially from the point of view of ancient Stoicism and its doctrine about the so-called non-demonstrable arguments.