bluuebunny/crossref_metadata_2025 huggingface dataset:
Outpatient antibiotic consumption for urinary infections in Croatia 2005 - 2014: What can be learned from utilization trends
Authors: Vojvodić Željko , Daus Šebeđak Danijela
Published: October 2018

Aim

The aim of this study was to determine quantities of antibiotics used mainly or exclusively for urinary tract infections in Croatia between 2005 and 2014, to describe utilisation trends, and general consequences of antibiotic consumption on antimicrobial resistance.

Methods

Antibiotic utilisation data were obtained from annual reports of both the Croatian Drug Agency and Croatian Academy of Medical Sciences. Antibiotic consumption was expressed in DDD/1000 inhabitants/day (DDD TID). Antimicrobial resistance was analysed for E. coli, E. faecalis, E. faecium, P. aeruginosa, Klebsiella spp., P. mirabilis. Descriptive statistics were used to process data and calculate trends.

Results

Overall, utilisation of antibacterials decreased by 4.8% (from 3,35 to 3,19 DDD TID), while trends of individual agents varied substantially – from 87% decline for ceftibuten to 160% rise for levofloxacin. The consumption of quinolones increased by 32.3%. This was mostly due to increased ciprofloxacin consumption (144% raise). Sulfamethoxazole-trimethoprim declined by 57%, while nitrofurantoin increased by 86%. The use of fosfomycin was marginal. Antimicrobial resistance of E. coli increased against quinolones by 54.5%, and against nitrofurantoin by 2–3%. Quinolone resistance of other pathogens (Klebiella spp, Proteus mirabilis), increased variably – between 17.2% (Klebsiella) and 90% (Proteus), while for P. aeruginosa remained the same at 22%.

Conclusion

High rates of antimicrobial utilisation require prescribing restrictions and educational interventions. The increased use of fluoroquinolones is a potentially serious public health threat due to the rapid development of resistance among uropathogens. This threat can be avoided by greater use of nitrofurantoin and fosfomycin.
Validation of the Slovenian version of motor imagery questionnaire 3 (MIQ-3): Promising tool in modern comprehensive rehabilitation practice
Authors: Paravlić Armin , Pišot Saša , Mitić Petar
Published: October 2018

Purpose

The high rate of injury incidence and its severity is estimated to cause approximately 9% of global mortality, while a large proportion of people surviving their injuries experience temporary or permanent disabilities. To reduce the occurrence of disability and improve general health of survivors, a more comprehensive rehabilitation approach is needed. Motor imagery is recognized as the promising cognitive strategy to counteract impaired functional capacity of the neuromuscular system. Thus, we aimed to provide to the Slovenian-speaking community a valid and reliable version of Motor Imagery Questionnaire – 3 [MIQ-3], that consists of kinaesthetic imagery [KI] and visual [i.e., Internal Imagery [IMI] and external imagery [EVI]] items.

Methods

We investigated both absolute and relative test-retest repeatability; construct validity and internal consistency of the KI, IMI and EMI items of the Slovenian version of MIQ-3 in 86 healthy adult subjects.

Results

Results showed high to very high average intra-class correlation coefficient [ICC] for the visual items [ICC=0.89] and KI items [ICC=0.92], whilst the measure of absolute variability presented as coefficient of variation [CV%] ranged from 4.9% [EVI] to 6.7% [KI]. The internal consistency was satisfactory [Cronbach α=0.91 [KI] and 0.89]) for both visual items. Confirmatory analysis confirmed a two-factorial structure of MIQ-3.

Conclusion

Understanding the content of the questionnaire is of utmost importance to ensure its effectiveness in rehabilitation practice. The Slovenian translation of the MIQ-3 is culturally and linguistically equivalent to the original English version.
Potensi Brazilein Potensi Brazilein dari Kayu Secang (Caesalpinia sappan L.) Sebagai Agen Depigmentasi Kulit Secara In Silico
Authors: Nugraha Wiratama , Suwartawan Wayan , Prayoga Andika , Laksmiani Linda , Putra Pradnyana , Ani Sasi
Published: October 2018

Hiperpigmentasi dan penggelapan kulit terjadi akibat sintesis melanin yang berlebihan yang disebabkan karena peningkatan aktivitas dari enzim tirosinase. Brazilein merupakan kandungan senyawa mayor yang terdapat dalam kayu secang (Caesalpinia Sappan L.) yang secara empiris mampu mencerahkan kulit. Penelitian ini bertujuan untuk mengetahui potensi dari brazilein sebagai agen depigmentasi kulit terhadap protein target enzim tirosinase secara in silico dibandingkan dengan hidrokuinon dan asam askorbat. Tahapan penelitian ini meliputi optimasi struktur brazilein, hidrokuinon dan asam askorbat 3D dengan menggunakan program Hyperchem 8, Preparasi protein target dengan menggunakan program Chimera 1.10.1, dan validasi metode molecular docking serta docking brazilein, hidrokuinon dan asam askorbat pada protein target menggunakan Autodock 4.2. Hasil pengujian molecular docking adalah energi ikatan. Analisis data dilakukan dengan membandingkan energi ikatan hasil docking brazilein pada protein target dengan hasil docking antara hidrokuion dan asam askorbat dengan protein target. Nilai energi ikatan brazilein, hidrokuinon dan asam askorbat dengan protein target enzim tirosinase berturut-turut adalah -6,70 kkal/mol, -3,78 kkal/mol dan -3,84 kkal/mol. Nilai energi ikatan brazilein lebih besar dibandingkan hidrokuinon dan asam askorbat pada protein target. Semakin rendah energi ikatan ligan dengan protein target, maka semakin kuat ikatan yang terbentuk antara ligan dengan protein target dan begitu juga afinitas dari ligan terhadap protein target yang berbanding lurus dengan kekuatan dan kestabilan ikatan tersebut. Perbandingan nilai energi ikatan pada table 4.2 menunjukkan bahwa brazilein memiliki potensi lebih besar sebagai agen depigmentasi kulit dibandingkan dengan hidrokuinon dan asam askorbat dengan mekanisme menghambat enzim tirosinase secara in silico dengan metode molecular docking
Essential Preparations for compliance and contingency options
Authors: DiCanna Debra
Published: October 2018

Even though the Ballast Water Management Convention (BWMC) (referred to herewith as the Convention) has been ratified and a few ballast water management systems (BMWS) have received US Coast Guard (USCG) type approval, many shipowners and operators are reticent to begin the significant process of planning for compliance with ballast water discharge and performance standards. This delay is most probably due to the uncertainty in the implementation dates in the BWMC and limited options of USCG type approved BWMS. These delays may result in significant ramifications for shipowners if the process for compliance is not fully evaluated. This process includes selecting, designing installation, purchasing, start-up and commissioning of BWMS. Clarity on the implementation schedule should be determined at the 71st session of the Marine Environmental Protection Committee of the International Maritime Organization (IMO MEPC 71) and allow shipowners to plan for compliance. An important aspect of implementation is developing a strong compliance plan. A central part of compliance is identifying possible problems and contingency options that may alleviate any potential port State control issues. The paper will identify possible problems and contingency measures to ensure ship operations are not impacted. An important issue is that the BWMC does not include provisions for contingency measures. The paper will also outline needed contingency measures to be addressed by the IMO in any amendments to the BWMC.
Rapid Compliance Monitoring using Indicative Tools
Authors: Mayerfeld Pam , Younan Lawrence
Published: October 2018

There is an ongoing question as to how ships will demonstrate their ballast water is in compliance with regulations when they pull into ports as well as how port State control might check this. Making a direct measurement of compliance can be a long process requiring skilled scientists and resulting in costly delays. Several companies have developed rapid compliance tools which make indicative measurements based on well-established scientific methods. The question is – what is being done in the maritime industry to show these indicative measurements are truly a good indication of compliance with the ballast water regulations? This paper presents why the 10-50 μm sample size is being used for these indicative measurements, the types of data presented by indicative tools, an overview of the various instruments being developed, and then most importantly, what organisations are validating compliance monitoring and what is the current status of their validations. In addition, some organisations who have already adopted using compliance monitoring in their processes and how they are using it will be included.
CMOS-based Image Cytometry for Detection of Phytoplankton in Ballast Water
Authors: Jofre M , Perez J M , Martinez P , Moubarak Z , Hurth C , Yanez MA , Catalan V , Parker A , Veldhuis M , Prunei V
Published: October 2018

An image cytometer (CYT) for the analysis of phytoplankton in fresh and marine water environments is introduced. A linear quantification of the number of cells over several orders of magnitude of concentrations was observed using cultures of Tetraselmis and Nannochloropsis measured by autofluorescence of the chlorophyll in a laboratory environment. The functionality of the system outside the laboratory was analysed by phytoplankton quantification of samples taken from marine water environment (Dutch Wadden Sea, The Netherlands) and fresh water environment (Lake Ijssel, The Netherlands). The CYT was also employed to study the effects of two ballast water treatment systems (BWTS), based on chlorine electrolysis and UV sterilisation by determining the vitality of the phytoplankton. In order to ensure the detection limit, a large volume (1l) of samples was collected and concentrated to 3 ml using CelltrapTM filters. The results were compared to benchmarked flow cytometer and PAM Fluorometry at Marine Eco-Analytics (MEA-NL). The image cytometer reached a 10 cells/ml limit of detection (LoD) with an accuracy between 0.7 and 0.5 log, and a correlation of 88.29% in quantification and 96.21% in vitality, when compared to benchmarked monitoring techniques.
Lessons Learned in Ballast Water Treatment Equipment Retrofit and Commissioning
Authors: Fearnley Robin
Published: October 2018

Ratification of the International Maritime Organization (IMO) International Convention for the Control and Management of Ships' Ballast Water and Sediments (BWMC)[i] has now forced the hand of operators and ship owners to comply with the BWM, and without a great deal of time to react. The need to integrate and operate Ballast Water Treatment (BWT) Systems on In-Service ships, however, is not new, and BMT have recent and relevant experience in end-to-end BWT system solutions. In 2011 BMT Defence Services Ltd (BMT) produced the installation specification to enable A and P Falmouth Ltd (A and P) to carry out a ballast water treatment plant retrofit installation on the RFA Bay Class ships (i.e. RFA MOUNTS BAY, LARGS BAY and CARDIGAN BAY), enabling the ship to be approved and operated in compliance with the BWMC. In addition, BMT produced documentation to enable A and P to arrange, manage and perform the necessary test, trials and commissioning to prove the equipment installation and that it can be operated in accordance with the requirements of the BWMC. The objective of this paper is to take the reader through the process of design and embodiment of a BWT system retrofit on a relatively complex (with respect to the ballast system) ship. The Bay Class ships are Landing Ship Dock (Auxiliary) ships with separate forward and aft ballast systems (to allow the ships to function in their amphibious roles by way of their stern dock), and a ship wide Ballast Stripping system. Key design and engineering considerations are discussed below and recommendations for the installation of a ballast water treatment system are also offered. International Convention for the Control and Management of Ships' Ballast Water and Sediments, International Maritime Organization, Adoption: 13 February 2004; Entry into force: 8 September 2017.
Selecting a suitable Ballast Water Treatment System for a small general cargo vessel
Authors: Clare Alan
Published: October 2018

The main questions which will be addressed in this paper are; which ballast water treatment system (BWTS) should be fitted to a fleet of small general cargo ships that are trading in Northern Europe, including the Baltic Sea, and how will the implementation of the Ballast Water Management Convention (BWMC, herewith “the Convention”) will affect the engine room crew? There is a large capital cost in the purchasing and fitting of such a system, and as the vessels in question have some special requirements, such as operating in very cold weather and having small engine rooms, the correct system must be chosen. As the small engine room crew, consisting of a chief engineer and an oiler, must be able to operate, maintain and repair the system, the chosen system will impact on their working life while onboard these vessels. To answer the research questions, all the chief engineers employed by the Company and a number of shore superintendents from other shipping companies, involved in the management of small general cargo ships were surveyed using questionnaires. Their responses were then analysed and conclusions drawn from this analysis. The criteria required to choose a ballast water treatment system was narrowed down during the research, and then used to find the most suitable system for the company vessels. A small number of systems currently in production from well-known manufacturers were evaluated during this process. Following evaluation of the systems using the responses from the respondents, the most suitable system for the company vessels was identified and chosen. The need for training was also identified to successfully operate and maintain the system, and to reduce any additional stress that may be experienced by the crew due to the BWMC. The research also contains a review of the BWMC, and a comparison with measures brought in by the United States Coast Guard (USCG), which include the transfer of harmful aquatic organisms and pathogens, (HAOP) by merchant vessels from area to area by other methods that are ignored by the BWMC. It also considers the long-term health effects on the crew and marine ecosystem from treated ballast water using some types of treatment systems. The report of the survey provides scope for a more informed decision making process when choosing a BWTS for a small general cargo vessel. However, in addition, the process can be applied to any type of vessel as many of the issues encountered will be the same regardless of size and trading pattern.
Ballast Water Treatment System Integration with the Ship Alarm and Monitoring System
Authors: Mackey James. P , Boyd Jared
Published: October 2018

Integration with the vessel Automation and Control system is a critical milestone in a Ballast Water Treatment System (BWTS) retrofit project. When completed properly, it provides for simple and intuitive operation of the BWTS and supports compliance with ballast water regulations. Integration results in seamless operation and monitoring of the ballast pumps and valves together with the BWTS at control stations in the Engine Control Room and/or bridge. It provides appropriate interlocks and alarms to ensure that the BWTS is not bypassed through ship’s valves, which are not controlled and monitored by the BWTS. It also encourages and supports the required log entries in the Ballast Water Logbook. A structured approach to this integration work results in fleet wide consistency, providing maximum benefit to the owner by reducing the risk of non-compliance as well as reducing the future cost of technical support and training.
Ballast Water Management: Policy to Sampling - the Orkney Experience
Authors: Sawkins David , Kakkonen Jenni
Published: October 2018

Orkney Islands Council is the Statutory Harbour Authority for Scapa Flow – a 324.5km2 area of deep water and sheltered anchorage in the Orkney Islands, north of mainland Scotland, with a long history and present use by all types of shipping. This paper will provide a short introduction to the development of the IMO and EU Directive compliant Ballast Water Management Policy for Scapa Flow which was approved by the competent planning authority in December 2013. Scapa Flow is in an environmentally sensitive area, this along with best practice was taken into account when developing the Policy – which includes strict and enforceable requirements on vessels and the Harbour Authority with regards to operations, monitoring and reporting. Since its approval there have been thirty-three occasions where ballast water discharge into Scapa Flow (by various types of vessels) has been requested. The Policy requires that vessels requesting to discharge ballast water into Scapa Flow must exchange and treat (where a treatment system is fitted) on every visit to Scapa Flow (no exceptions or exemptions allowed). To date thirty-one vessels have carried out exchange and two have carried out exchange and treat – all as per the Policy. This paper will deal with the setting of an IMO compliant Ballast Water Policy through to practical application by a Statutory Harbour Authority for a period of three years from 2013 to present day – with examples of ship types, amounts, any restrictions imposed, checks and reports made. It will include – with input from the Harbour Authority’s Marine Environment Unit lead by Jenni Kakkonen –a review of the positive actions, problems, solutions and overall results obtained so far regarding taking ballast water samples from these vessels, analysing the same and recording of details. There is a continual review and reporting process with regards to the effectiveness of the Policy to the Orkney Marine Environment Protection Committee (comprising of all the relevant statutory advisors and interested groups). The paper will contain the Harbour Authority’s way ahead in order to remain compliant, maintain its knowledge base of new technologies and environmental reports – all with the continued aim of maintaining the environment and commercial sustainability of Scapa Flow as a leading port and harbour.
Hydrodynamic cavitation as a treatment process for vessel ballast water management
Authors: Levey Michael
Published: October 2018

Global Advantech Resources has identified that hydrodynamic cavitation, a technology it has been harnessing for a number years for completely different, unrelated application, is capable of being utilised as an efficient and cost effective method for ballast water treatment to treat very large pumped water flows within a short period of time.
The Evolving World of BWMS Approvals
Authors: Merksamer Marcie
Published: October 2018

Revisions to the Guideline 8 (G8) type approval procedures for ballast water management systems (BWMS) were recently completed during the seventieth session of the International Maritime Organization’s (IMO) Marine Environment Protection Committee (MEPC 70). Key changes to G8 and their potential to impact the testing and availability of approved BWMS are considered. The additional approvals, such as US Coast Guard type approval, classification society approvals, and flag State approvals that BWMS manufacturers are required to obtain are also proving to be evolutionary. These various BWMS approvals, their complexities and how they interplay with each other are discussed. Further, conceptual solutions related to streamlining BWMS approvals in support of ballast water regulation implementation are presented.
In Ovo β-Alanin Solüsyonu Alan Yeni Çıkmış Etlik Piliç Civcivlerinde Kuluçka Randımanı, Bazı Kuluçka Parametreleri, Kalite Skoru ve Yaşama Gücü
Authors: Kop Bozbay Canan , Akdağ Ahmet , Atan Helin , Ocak Nuh
Published: October 2018

Bu çalışma, alanin amino asitinin değiştirilmiş edilmiş bir formu olan β-Alaninin (βA) etlik piliç damızlık yumurtalarına In ovo enjeksiyonunun kuluçka randımanı, civciv çıkış ağırlığı, kalite skoru ve yaşama gücü üzerine etkileri değerlendirmek için yapılmıştır. Bu amaçla, 32 haftalık yaşta Ross 308 etçi damızlıklardan elde edilen toplam 120 adet döllü yumurta 3 tekerrürlü 4 gruba rastgele dağıtılmıştır. Negatif kontrol (NK) grubundaki yumurtalara herhangi bir işlem yapılmazken, diğer 3 gruptaki yumurtaların amniyotik sıvısına kuluçkanın 18. gününde 1 ml %0,9 tuz (pozitif kontrol, PK), %0,75 (0,75βA) veya %1,5 (1,5βA) βA solüsyonu 19 mm ve 27 gauge uçlu iğne ile enjekte edilmiştir. Çıkışta, embriyonik gelişmenin değişik dönemlerindeki ölüm oranları, çıkış randımanı, civciv çıkış ağırlığı (CÇA) ve CÇA‘nın yumurta ağırlığına oranı (CÇA/YA) gibi bazı çıkış özellikleri ile civciv kalite skoru ve yaşama gücü kaydedilmiştir. 0,75βA grubundaki civcivlerin çıkış ağırlığı ve bu ağılığın yumurta ağırlığına oranı her iki kontrol grubundakilerden daha yüksek bulunmuştur. Civciv kalitesinin bir göstergesi olarak ölçülen yeme başlama süresi de 0,75βA civcivlerinde diğer civcivlerinkinden daha kısa olmuştur. Aksine, NK civcivlerinin hareketlilik puanı, diğer gruptaki civcivlerden daha yüksek bulunmuştur. In ovo βA, kuluçka randımanı, civciv kalite skoru ve civcivlerin ilk hafta yaşama gücünü etkilememiştir. Bu çalışmanın sonuçları, incelenen kuluçka parametrelerini ve yeni çıkmış civcivlerin ağırlığını, kalitesini ve yaşama gücünü olumsuz etkilemeksizin %1,5‘e kadar in ovo βA‘nin yemlemesini yapılabileceğini ve %0,75 In ovo βA alan etlik piliç civcivlerinin daha yüksek çıkış özelliklerine sahip olduğunu göstermiştir.
Analysis of Factors Affecting Consumers in UHT Milk Consumption: The Case Study of Erzurum
Authors: Uzundumlu Ahmet Semih , Birinci Avni , Kurtoğlu Seval
Published: October 2018

The primary purpose of this study was to determine factors influencing consumer preferences for UHT milk consumption in Erzurum province. The primary data used in this research was derived from Palandoken, Yakutiye and Aziziye districts of Erzurum province in 2010. The factor analysis was used to find out the factors affecting consumer preferences for UHT milk and to reduce these factors. As for the segmentation of consumers and bringing out the profile of each segment, cluster analysis was used. According to the results, 95.00% of households consumed UHT milk. 18 factors that are affecting the consumption of UHT milk were reduced to five main factors with factor analysis. The factor scores which determined with factor analysis were divided into three clusters by cluster analysis. UHT milk for consumers entering the first cluster has because of homogenous and packaging as well as intrinsic and extrinsic properties for advertising and price advantage is preferred. UHT milk for consumers entering the second cluster has ease of preparation and transportation, and confidential properties are preferred by reason. On the contrary, consumers entering the third cluster prefer to UHT milk for a good diet product.
Estudio de las desigualdades y la violencia contra las mujeres marroquíes. Una aproximación desde el modelo metodológico de mapas corporales
Authors: Orozco Orozco Carla , Soriano Ayala Encarnación
Published: October 2018

La violencia de género es entendida como una estructura que vulnera a las mujeres y que es construida desde la cultura del patriarcado, con el afán de obtener control y poder político por medio de la dominación de la mujer. El objetivo de esta investigación consistió en conocer cómo las desigualdades y las vivencias de violencia de género se han introyectado sobre el cuerpo en las mujeres marroquíes que viven en España. El presente estudio se realizó desde la metodología de mapas corporales. Esta metodología ha recogido experiencias biográficas del cuerpo de las mujeres. El principal resultado y conclusión que se ha obtenido de la lectura corporal ha sido que la violencia de género genera una cosificación y control del cuerpo femenino, que lucha constantemente por no someterse a la estructura machista que las violenta.  The gender-based violence is known as a structure that infringes women, and it is built from the patriarchal culture, with the aim of obtaining control and political power by dominating women. The research objective was to know how the gender-based violence experiences have introjected the Moroccan women who live in Almeria, Spain. The present study was conducted from the methodological model of body maps. This methodology has collected biographic experiences from women’s body. The main conclusion that has been obtained from the body reading is that gender-based violence generates an objectification and control over the female body, which constantly struggles to avoid submission over the macho structure that violates them.
RISK FACTORS OF LOW-ENERGY FRACTURES IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: NURULLINA G. M. , AKHMADULLINA G. I. , KRASNOPEROVA O. V. , ALEKSEEVA M. M. , ALEKSANDROVA O. V. , CHERNOVA A. V.
Published: October 2018

Osteoporosis is a metabolic disease of the bone tissue, which is characterized by a violation of the qualitative (microarchitecture  change) and quantitative characteristics (decreased bone mass) of  the skeleton, and, as a result, lowenergy fractures. The medical and  social significance of osteoporosis is due to its consequences:  fractures of the femoral neck, vertebral bodies, radius and other  large bones of the skeleton, which significantly reduces the quality of patients’ lives and entails significant financial costs for treatment and rehabilitation.  Prevalence of diabetes mellitus (DM) significantly  increases in all countries of the world, including the Russian  Federation. Diabetes and osteoporosis were considered to be  individual diseases for a long time. In many prospective large-scale studies it was proved that patients with T2DM have a greater risk of  falls and fractures in contrast with the overall population. Despite the increased risk of fractures in diabetic patients, there is still no risk  stratification in these patients. The link between the classic risk  factors of osteoporotic fractures (such as chronic intake of  glucocorticoids, use of alcohol, tobacco, etc.) and the occurrence of  fractures is similar in patients with both T2DM and without it.  However, it is necessary to take into account other characteristics of  diabetes. The specific risk factors of fractures in T2DM patients are  duration of the diabetes for more than 10 years, diabetes decompensation, the severity of diabetes, obesity, the frequency of  falls, hypoglycemia, insulin, thiazolidinedione, exenatide, sulfonylureas, canagliflozin therapy, and, most likely, the reduction  of 25 (OH) vitamin D, functional hypoparathyroidism, the increase of sclerostin, pentosidine, decreased bone mineral density (BMD) of the hip.
VISUALIZATION OF THE EXCITATION PROCESS IN THE FROG'S NERVES
Authors: KORNILOVA N. V. , ABUSHKEVICH V. G. , ARDELYAN A. N. , PEROVA Yu. Yu. , POKHOT'KO A. G.
Published: October 2018

Aim.Visualization of the excitation process in the frog's nerves.

Materials and methods. Observations were carried out on 30 immobilized frogs. Vagosympathetic trunks and sciatic nerve were  allocated from the frogs. Ligatures were placed on the right  vagosympathetic trunk crossing it. A scanner of the gas discharge  visualization camera of the CELSY device, which created a high- frequency electromagnetic field (1024 Hz), was installed above the  nerves. The scanner with a highly sensitive camera shot a 60-second video (the frequency of frame-by-frame shooting to 1000 frames per second), during which the edge luminescence (Kirlian effect) and the  glow spots were recorded inside the nerve. The  electrocardiogram (ECG) was synchronously recorded in the I  standard lead. The processing of the obtained results was carried out according to the area of the glow spot, the area of the highest luminescence brightness, the direction of the movement of  the foci of the luminescence, and the linear velocity of the movement of the glow foci.

Results.Foci of the internal luminescence appeared only in the high-frequency electromagnetic field in the sciatic nerve of the frog  when the nerve was stimulated by electrical impulses, which resulted in the contraction of the frog's foot. Glow foci of the brain  synchronous to the heart rhythm and preceding the tooth of the V- wave on the frog’s ECG were observed at the central end of the cut  of the frog’s vagosympathetic trunk.

 

Conclusion.Visualized foci of luminescence in the nerve reflect the neural activity.
ASSESSMENT OF EFFECTIVENESS OF ANTI-RECURRENT AND HORMONAL THERAPY IN WOMEN WITH UTERINE FIBROIDS IN PREGRAVIDAL PREPARATION
Authors: KHOROLSKY V. A. , DRJAEVA L. G. , MEDVEDEVA L. A. , BARSUK A. V. , SAYNOGA T. V.
Published: October 2018

Aim. This study was designed to evaluate the effectiveness of sequential prescription of drugs for anti-recurrent therapy of the uterine fibroids (UF) and combined oral contraceptives (COC) in pregravidal preparation.

Materials and methods.There was conducted a prospective, nonrandomized and controlled cohort study of 150 women with UF  who are planning a pregnancy after the organ-preserving treatment  of uterine fibroids by means of myomectomy with laparoscopic  access and pregravidal preparation. The immunohistochemical (IHC)  study of the intensity expression of Ki 67, p53, Bcl-2 was performed  for the differential diagnosis of reactive proliferation from dysplasia  in the distant fibroid node and the selection of anti-recurrent therapy.

Results. The duration of the UF disease does not depend on the intensity of expression of p53, Ki-67 or Bcl-2, the level of expression  of the progesterone receptors in the distant fibroid node. A negative average correlation between the level of hemoglobin  before myomectomy, the duration of the disease (r = -0.3867) and  the number of nodes (r = -0.5389) was revealed. After the end of  the anti-recurrent treatment in women who underwent organ- preserving treatment of uterine fibroids, the prescription of COC is connected with a further decrease in the size of fibroid nodes remaining after myomectomy from 15.81±0.22 mm to 8.94±0.45  mm (p<0.05), the number of fibroid nodes from 2.25±0.08 to  0.91±0.06 (р<0.05).

Conclusion.The combination of anti-recurrent therapy with the subsequent prescription of the COC for prevention of the UF growth  in women planning a pregnancy after myomectomy with endoscopic  access is highly effective.
Sport and sport media as a culture industry product
Authors: Özsoy Selami
Published: October 2018

Today, the concept of
sports is associated with commercialized and industrialized elite sports
instead of the activities that are required to sustain healthy lives. Sport is
the first area in which capitalism can deepen its hold on society and renew it.
This conceptual study examines how Marxist critical theorists, led by Frankfurt
school of thought and French structuralism, address sports. According to
critical theorists; culture industry products such as cinema, television and
music entertain and divert the masses from thinking about the realities of
life. Today’s culture industry which is based on commodification serves to
spread a shallow culture instead of a culture with depth. Sports, transmitted
to the masses via the media, are now a part of this shallow culture. According
to culture industry, first conceptualized by the representatives of the
Frankfurt school of thought Adorno and Horkheimer, masses have become the objects
that are shaped by the culture instead of subjects that establish it. When
considered as a part of the culture industry, sports are one of the mass
entertainment and diversion tools that define the lifestyle of individuals. According
to critical thinkers, sports such as football -the focus of interest for the
masses- is a field in which injustice in income distribution is legitimized.
A Designed Protein Binding-Pocket to Control Photochemical Isomerization
Authors: Lampkin Bryan J. , Monteiro Cecilia , Powers Evan T. , Bouc Paige M. , Kelly Jeffery W. , VanVeller Brett
Published: October 2018

ESIPT involves a photochemical isomerization and creates the opportunity for the emission of two distinct wavelengths of light from a single fluorophore. The selectivity between these two wavelengths of emission is dependent on the environment around the fluorophore and suggests the possibility for ratiometric monitoring of protein microenvironments. Unfortunately, nonspecific binding of ESIPT fluorophores does not often lead to dramatic changes in the ratio between the two wavelengths of emission. A protein binding pocket was designed to selectively discriminate between the two channels of emission available to an ESIPT fluorophore. More broadly, this work demonstrates that specific interactions between the protein and the fluorophore are essential to realize strong ratiometric differences between the two possible wavelengths of emission. The design strategies proposed here lead to an ESIPT fluorophore that can discern subtle differences in the interface between two proteins.
Self-Assembling Micelles Based on an Intrinsically Disordered Protein Domain
Authors: Klass Sarah , Smith Matthew J. , Fiala Tahoe , Lee Jessica , Omole Anthony , Downing Kenneth , Francis Matthew
Published: October 2018

Herein, we describe a new series of fusion proteins that have been developed to self-assemble spontaneously into stable micelles that are 27 nm in diameter after enzymatic cleavage of a solubilizing protein tag. The sequences of the proteins are based on a human intrinsically disordered protein, which has been appended with a hydrophobic segment. The micelles were found to form across a broad range of pH, ionic strength, and temperature conditions, with critical micelle concentration (CMC) values below 1 µM being observed in some cases. The reported micelles were found to solubilize hydrophobic metal complexes and organic molecules, suggesting their potential suitability for catalysis and drug delivery applications.
A Bottom-Up Approach to Solution-Processed, Atomically Precise Graphitic Cylinders on Surfaces
Authors: Leonhardt Erik , Van Raden Jeff M. , Miller David , Zakharov Lev N. , Aleman Benjamin , Jasti Ramesh
Published: October 2018

Extended carbon nanostructures, such as carbon nanotubes (CNTs), exhibit remarkable properties but are difficult to synthesize uniformly. Herein, we present a new class of carbon nanomaterials constructed via the bottom-up self-assembly of cylindrical, atomically-precise small molecules. Guided by supramolecular design principles and circle packing theory, we have designed and synthesized a fluorinated nanohoop that, in the solid-state, self-assembles into nanotube-like arrays with channel diameters of precisely 1.63 nm. A mild solution-casting technique is then used to construct vertical “forests” of these arrays on a highly-ordered pyrolytic graphite (HOPG) surface through epitaxial growth. Furthermore, we show that a basic property of nanohoops, fluorescence, is readily transferred to the bulk phase, implying that the properties of these materials can be directly altered via precise functionalization of their nanohoop building blocks. The strategy presented is expected to have broader applications in the development of new graphitic nanomaterials with π-rich cavities reminiscent of CNTs.
Noncollinear Relativistic DFT+U Calculations of Actinide Dioxide Surfaces
Authors: Pegg James , Shields Ashley E. , Storr Mark T. , Scanlon David , De Leeuw Nora
Published: October 2018

A noncollinear relativistic PBEsol+U study of the low-index actinide dioxides (AnO2, An = U, Np, Pu) surfaces has been conducted. The surface properties of the AnO2 have been investigated and the importance of the reorientation of magnetic vectors relative to the plane of the surface is highlighted. In collinear nonrelativistic surface models, the orientation of the magnetic moments is often ignored; however, the use of noncollinear relativistic methods is key to the design of reliable computational models. The ionic relaxation of each surface is shown to be confined to the first three monolayers and we have explored the configurations of the terminal oxygen ions on the reconstructed (001) surface. The reconstructed (001) surfaces are ordered as (001)αβ < (001)α < (001)β in terms of energetics. Electrostatic potential isosurface and scanning tunneling microscopy images have also been calculated. By considering the energetics of the low-index AnO2 surfaces, an octahedral Wulff crystal morphology has been calculated.
n. 179 (15): Dor On Line
Authors: Barboni Paulo
Published: October 2018

Edição de Junho de 2015 - Ano 15 - Número 179

Caros leitores, nesta edição de Junho trazemos um editorial tratando da dor neuropática no câncer. Além disso, temos em nossa sessão de Divulgação Científica alertas sobre uso do Botox na enxaqueca; um caso curioso de analgesia congênita aqui no Brasil; a influência de alterações no sono na percepção da dor; um interessante estudo sobre os efeitos nocebo e placebo na produção de prostaglandinas e efeito analgésico; e uma interessante descrição sobre a Síndrome do Túnel do Carpo. Na seção de Ciência e Tecnologia, apresentamos alertas sobre a função de Neurônios descendentes dopaminérgicos na manutenção da dor; transplante de neurônios gabaérgicos embrionários para tratamento da dor neuropática; diferentes contribuições de fibras A e C para a hiperalgesia inflamatória; uma nova combinação de fármacos para a polineuropatia; e evidências de uma protease como mediadora da nocicepção oncológica. Boa leitura!

EDITORIAL DO MÊS

Etiologia, características, mecanismos e controle da dor neuropática associada ao câncer: uma breve abordagem.

Divulgação Científica

1. E quando a dor não é sentida? A mulher que não sente dor e que pegou no sono enquanto dava à luz.

2. Botox na enxaqueca. Diminuição de marcador inflamatório após o tratamento com toxina botulínica em pacientes com enxaqueca crônica.

3. Noites mal dormidas: Isto influi na sua sensibilidade a dor? Até onde dormir mal traz influências no limiar de dor.

4. Nocebo e placebo são capazes de modular a síntese de COX e prostaglandinas. Um mecanismo de redução da dor por placebos e nocebos.

5. Síndrome do Túnel do Carpo, Osteoartrite. O que é?

Ciência e Tecnologia

6. Neurônios descendentes dopaminérgicos na manutenção da dor. Mecanismos da dopamina podem oferecer novos tratamentos pra a dor crônica.

7. Transplante de neurônios gabaérgicos embrionários como possível tratamento da neuropatia. Será possível?

8. Diferentes contribuições de fibras A e C na hiperalgesia inflamatória primária e secundária. Quando fibras C facilitam a ativação de fibras A.

9. Combinação Imipramina e Pregabalina para polineuropatia dolorosa. Um estudo clínico.

10. Um novo mediador ancorado a membrana na dor oncológica. O TMPRSS2 é uma protease relacionada à dor.
n. 200 (17): Dor On Line
Authors: Barboni Paulo
Published: October 2018

Edição de Março de 2017 - Ano 17 - Número 200

Um longo caminho percorrido! 200 edições! Nosso editorial desta edição comemorativa conta um pouco sobre esta história! Obrigado a você leitor por partilhar conosco esta jornada de divulgação científica sobre o estudo da dor. Na nossa seção de Divulgação Científica temos alertas tratando sobre a sintonia da mente e o alívio da dor, a eficácia do diclofenaco na artrite e artrose, a ioga contra dor nas costas, a prevalência da dor em veteranos de guerra e a educação no DOL. Na seção de Ciência e Tecnologia temos alertas tratando do Canal Nav1.1, um estudo sobre drogas na dor evocada e dor espontânea, a abstinência de opioides e canais pannexin-1 microgliais e um estudo clínico sobre o canal PIEZO2. Boa Leitura!

EDITORIAL DO MÊS

Editorial do mês

200

José Waldik Ramon

Divulgação Científica

1. Sintonize seu cérebro e diminua sua dor. Cientistas descobriram que estimular ondas cerebrais específicas pode ajudar no alívio da dor.

Larissa Garcia Pinto

2. Estudos apontam eficácia de AINES no tratamento de osteoartrite e artrite reumatoide. As condições dolorosas crônicas são temidas em toda a população.

Rafael Poloni

3. Ioga e seus benefícios na dor nas costas. Estudo comprova sua eficácia.

Rafael Poloni

4. Dor intensa em veteranos militares. Estudo fornece estimativas nacionais da prevalência de veteranos militares dos Estados Unidos.

Andressa Daiane de Carvalho Zaparolli

5. Projeto Dor On Line. Um projeto educacional em um projeto de extensão.

Paulo Gustavo Barboni Dantas Nascimento

Ciência e Tecnologia

6. Canal Nav1.1 regula a excitabilidade de nociceptores envolvidos na hipersensibilidade mecânica. Toxinas de aranha ativam Nav1.1 induzindo dor.

Larissa Garcia Pinto

7. Diferentes efeitos de drogas. Os estudos animais com comportamentos nociceptivos evocados e os pacientes de dor neuropática com dor espontânea

Erika Ivanna Araya Pallarés

8. Bloqueio de canais pannexin-1 microgliais alivia a gravidade da retirada de opioides. Alivio da dor e melhora dos sintomas da síndrome de abstinência aos opioides.

Francisco Fábio Bezerra de Oliveira

9. O papel do canal PIEZO2 na mecanosensitização humana. Evidências clínicas da ação do canal.

Paulo Gustavo Barboni Dantas Nascimento

10. Mecanismo de alteração na percepção dolorosa do autista. Será apenas comportamental e psicológico, ou também patofisiológico?

Andreza Urba de Quadros
Avaliação da qualidade microbiológica de filés de tilápia-do-nilo (Oreochromis niloticus) e do gelo e a interação dos fatores após armazenagem
Authors: Coutinho Moura Camila Maria , De Abreu Costa Juliana , Martins de Sousa Aline , Santos Filho José Humberto , Gomes Abreu Bacelar Rafael , Teixeira de Oliveira Santos Julliet , Sanches Muratori Maria Christina
Published: October 2018

O presente trabalho objetivou analisar a qualidade microbiológica do filé de tilápia (Oreochromis niloticus) e do gelo comercializado no Mercado do Peixe em Teresina, PI e avaliar a interação de contaminação entre as partes analisadas. Foram coletadas 24 amostras de peixes e três amostras de gelo no Mercado do Peixe em Teresina, PI, os peixes foram transportadas em caixas isotérmicas para o laboratório onde foram filetados. A primeira etapa consistia nas análises microbiológicas do filé e do gelo para contagem de bactérias heterotróficas mesófilas e psicrotróficas e enumeração de coliformes termotolerantes e totais. A outra parte do filé foi acondicionada em caixa isotérmica com a amostra de gelo para estocagem por oito horas, período este que corresponde ao período de comercialização no mercado do peixe. Decorrido esse tempo também eram realizadas as mesmas análises microbiológicas. Pode-se verificar que as amostras de gelo que foram analisadas imediatamente após chegar ao laboratório não apresentavam contaminação microbiológica. Entretanto, as amostras de filé possuíam índices semelhantes de contaminação bacteriana antes e após estocagem. O gelo que após ser utilizado para o acondicionamento do filé apresentou quantidade de bactérias heterotróficas mesófilas e psicrófilas semelhantes aos filés.
DOS LIMITES DO RISCO PERMITIDO PARA AS PESSOAS JURÍDICAS: uma análise do defeito de organização como um problema de imputação objetiva
Authors: Xavier Januário Túlio Felippe
Published: October 2018

Pretende-se, com o presente trabalho, estabelecer os critérios de aplicação da teoria da imputação objetiva no âmbito do injusto empresarial, a partir de um modelo construtivista de autorresponsabilidade penal das pessoas jurídicas. Para tanto, após uma análise do contexto global e financeiro no qual se inserem os crimes econômicos, serão examinados os fundamentos, modelos e eventuais aproveitamentos, tanto da teoria da imputação objetiva, quanto da responsabilidade penal dos entes coletivos, visando traçar as bases para o derradeiro capítulo, no qual se objetiva comprovar a necessidade e complementariedade destes institutos.
ПРИМЕНЕНИЕ ТЕХНОЛОГИЙ ЦИФРОВОГО МАРКЕТИНГА НА ПАРФЮМЕРНО-КОСМЕТИЧЕСКОМ РЫНКЕ
Authors: Комбарова Ирина Владимировна , Борисова Александра Андреевна
Published: October 2018

Цель работы. Целью работы является анализ основных тенденций влияния формирующихся цифровых технологий на рынок парфюмерии и косметики, как в количественном, так и в качественном измерении. Метод или методология проведения работы. Применялся широкий спектр методов сбора фактического материала и его обработки, проведены собственные исследования особенностей потребительского поведения на основе первичных источников информации. Проанализированы данные мониторинга и анализа отраслевых и общеэкономических событий в России и мире ведущих аналитических агентств. Результаты. Исследование включает описание тенденций развития российского и зарубежного парфюмерно-косметического ритейла, что позволяет сравнить развитие российского рынка с рынками других стран, выявить аналогии и построить прогноз развития. На основе анализа вторичных данных выявлены ключевые направления дальнейшего развития парфюмерно-косметического ритейла. Сделан вывод о том, что развитие интернет-технологий вынуждает бизнес перестраивать маркетинговую стратегию под изменившуюся внешнюю среду и активно использовать digital-инструменты, принципиально менять свою систему маркетинговых коммуникаций, формировать виртуальную инфраструктуру бизнеса, развивать интернет-маркетинг, управление взаимоотношениями с клиентами на основе CRM-систем, внедрять маркетинг-аналитику (или бизнес-аналитику) и т. п. Развитие цифровых технологий приводит к тому, что важным фактором конкурентоспособности становится скорость ведения бизнеса, внешней и внутренней логистики, бизнес-процессов, принятия и реализации управленческих решений. Область применения результата. Результаты проведенного исследования могут быть использованы в качестве рекомендаций российскими компаниями по использованию возможностей интернет-технологий для роста бизнеса. Выводы. Развитие цифровых технологий и меняющиеся потребительские тренды приводят к необходимости использования digital-инструментов маркетинга для успешного развития бизнеса.
ОЦЕНКА И МОДЕЛИРОВАНИЕ ФИНАНСОВОЙ ПОЗИЦИИ КРЕДИТНОГО УЧРЕЖДЕНИЯ
Authors: Зоидов Кобилжон Ходжиевич , Пономарева Светлана Васильевна , Серебрянский Даниил Игоревич
Published: October 2018

Предмет. В статье рассматривается финансово-хозяйственная деятельность на примере Банка Y. Мнения о финансовом положении и анализе высказывали различные авторы, таким образом, в статье приведен анализ взглядов исследователей по тематике работы, и выделены и описаны характерные особенности их понятий. Цель работы. Особое внимание в работе авторы акцентируют на анализе «Консолидированного отчета о финансовом положении» и «Консолидированного отчета о прибыли или убытке и прочем совокупном доходе». Методология проведения работы. В процессе исследования использованы методы эволюционно-институциональной теории, эконометрического моделирования и аналитической оценки. Результаты работы. С помощью горизонтального анализа удалось выявить проблематичные зоны, с которыми «Банк Y» имеет проблемы. В статье излагаются взгляды на феномены выявленных вопросов. В качестве разработки методики анализа финансового положения взята цель исследования, которая помогает охватить более узкий спектр тематики научного исследования. Выводы. Проведенный анализ позволил сформулировать выводы и заключить цели настоящего исследования, выявить возможные актуальные проблемы и пути их решения, образуя базу исследования для финансового состояния банков в Российской Федерации. Для решения проблем была разработана специальная модель оценки финансового состояния кредитного учреждения. Обобщен практический смысл в управлении анализируемым объектом с помощью получения информации. Область применения результатов. Результаты могут быть использованы в исследованиях по проблемам банковского сектора национальной экономики в условиях глобальных трансформаций, а также при подготовке планов по финансово-денежной политике.