bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mechanism of Propofol on Non-Small Cell Lung Cancer (NSCLC) through Modulating Mesenchymal Transition (EMT)
Authors: Yang Yi , Zuo Yiding , Zhou Li
Published: January 2023

Background: Intensive investigations have focused on the effect of propofol on the malignant behaviours of cancer cells. However, much is still unknown about the effect of propofol on non-small cell lung cancer (NSCLC). Here we aimed to investigate the effect of propofol on NSCLC with cancer stem-like cells (CSCs) A549.
Methods: CCK-8 assays, flow cytometry, and transwell assay were used to assess the changes in the proliferation, migration, and invasion in A549 treated with propofol. By detecting hallmarks of mesenchymal transition (EMT), the mechanism of the effect of propofol on A549 was assessed.
Results: In A549, propofol exposure promoted cell proliferation, while inhibiting migration and invasion. By activating EMT using TGF-β pretreatment, propofol treatment downregulated hallmarks of EMT and led to inactivation of EMT.
Conclusion: Modulation of self-renewal capacity of CSCs by anesthetics may affect cancer malignant behaviors following surgery. The employment of propofol not only exerts inhibitory effects on cancer cells but also on CSCs in non-small cell lung cancer.
Seasonal Variation of Glucose Variability in Rather Elderly Patients with Type 2 Diabetes (T2D) Treated by Vildagliptin and Metformin (EquMet)
Authors: BANDO Hiroshi , YAMASHITA Hisako , KATO Yoshinobu , KAWATA Takafumi , KATO Yoshikane , KANAGAWA Hiroe
Published: January 2023

Background: Seasonal variation of HbA1c has been in focus.
Patients and Methods: The protocol included type 2 diabetes (T2D) patients (n=26, 71.4±10.2 years) on vildagliptin and metformin (EquMet) and HbA1c changes in 4 seasons for 6 years.
Results: HbA1c values ranged 6.9-7.5%, and tend to show highest in winter, and rather lower in autumn.
Discussion & Conclusion: Rather elderly T2D cases can tolerate EquMet with fair control. Previous reports showed a similar tendency. Some factors may be involved in the variation, such as temperature, climate, carbohydrate intake, Ramadan, and others. Furthermore, blood pressure and cardiovascular disease (CVD) can also influence them.
High Incidence and Mortality Diseases Control is more Imperative Apart from COVID-19 in China
Authors: Han-You Xu
Published: January 2023

Objective: In order to enhance the health level, treat and cure well all the diseases, especially the high incidence and mortality diseases. So as to save the life and promote the quality of life. The research has been done to find the facts that that much more death caused diseases apart from the COVID-19 have been killing the people even worse at the COVID-19 pandemic time.
Methods: Summarized the data extracted from three public official internets, the National Bureau of Statistics of China, the WHO and the International Diabetes Federation. Found out the health problems and health influenced diseases data apart from the COVID-19 in China. And analysing the data and facts.
Results: Based on the three channels of official internet, check and look up the valuable data, find out the demanded data and reorganize, build new tables. So the concrete facts to show the critical Chinese health problems apart from COVID-19 have been found.
The 12 tables have been created and found that in China, the leading causes of death are Cardiovascular diseases, Malignant neoplasms, Respiratory diseases, Diabetes mellitus, injuries. The diseases have not been prevented and cured. The total death in China has been being more and more. The communicable diseases of Viral Hepatitis and Pulmonary Tuberculosis have been being the No.1 and No.2 incidences in Chinese communicable infections. The mortality of Heart Diseases in Chinese rural areas has been being in fast trend of heavier and heavier, from 87.10 in 2008 to 171.36 in 2020 and in recent three years the No. 1 killer in Chinese rural areas. The explosively developed incidence of diabetes mellitus from the year 2000 in 22564.80 cases (in 1000s) exploded into 90045.10 cases (in 1000s) at 2011, and much too more cases developed up to now.
Conclusion: In China, much more works must be done to control the leading causes of death, the diseases incidence and prevalence undermining health, including the Cardiovascular diseases, Malignant neoplasms, Respiratory diseases, Diabetes mellitus, injuries apart from COVID-19, especially the heart diseases in Chinese rural areas has been being the No. 1 killer in recent three years. The communicable diseases of Viral Hepatitis and Pulmonary Tuberculosis must be controlled and prevented.
The urgently needed actions to control the leading causes of death, incidence and prevalence apart from COVID-19 in China may be referenced by other countries and international health organizations.
Latest Development of Administration Routes for Anti-Diabetic Agents using Insulin Nanoparticles (NPs)
Authors: BANDO Hiroshi
Published: January 2023

For the latest development for anti-diabetic agents, nanoparticles (NPs) have been in focus. Permeation enhancers (PEs) are known to increase the oral absorption of various kinds of macromolecules. One of PEs would be sodium N-[8-(2-hydroxybenzoyl) amino] caprylate (SNAC), which has been used for glucagon-like peptide-1 receptor agonist (GLP-1RA) as oral semaglutide (Rybelsus). For insulin encapsulation, polyelectrolyte nanocomplex (PEC) have been the promising carriers. Furthermore, spray drying technique has been an adequate and well-known industrial method for developing pharmaceutical industries, and aqueous polymer dispersions (APDs) have been applied. Consequently, self-nanoemulsifying drug delivery systems (SNEDDS) can be expected to improve future diabetic treatment.
Robotic Surgery in Total Hip Replacement in Obesity
Authors: Almashahedi Mohammed , Khan Wasim , McDonnell Stephen
Published: January 2023

Total hip replacement is one of the most successful orthopaedic operation of recent time. The outcomes of THR may be influenced by several factors including patient demographics, surgical technique and implant features. One of the most important surgeon-controlled factors is component positioning. Surgical positioning of the acetabular cup and femoral prosthesis remains fundamental to obtaining accurate implant fit and prevent hip dislocation or impingement. Different categories of robotic assistance have been established during the previous years and all of the technologies target accuracy and reliability to reduce complications, and enhance clinical outcomes.

In this article, we discuss the advantages and difficulties of robotic total hip replacement in obese patient and provide the recent scientific evidence from the literatures.
Diagnosis of Thyroid Malignancy using Levels of Chemical Element Contents in Nodular Tissue
Authors: Zaichick Vladimir
Published: January 2023

Introduction: Thyroid benign (TBN) and malignant (TMN) nodules are a common thyroid lesion. The differentiation of TMN often remains a clinical challenge and further improvements of TMN diagnostic accuracy are warranted. The aim of present study was to evaluate possibilities of using differences in chemical elements (ChEs) contents in nodular tissue for diagnosis of thyroid malignancy.
Methods: Contents of ChEs such as aluminum (Al), boron (B), barium (Ba), calcium (Ca), chlorine (Cl), coper (Cu), iron (Fe), iodine (I), potassium (K), lithium (Li), magnesium (Mg), manganese (Mn), sodium (Na), phosphorus (P), sulfur (S), silicon (Si), strontium (Sr), vanadium (V), and zinc (Zn) were prospectively evaluated in “normal” thyroid (NT) of 105 individuals as well as in nodular tissue of thyroids with TBN (79 patients) and to TMN (41 patients). Measurements were performed using a combination of non-destructive and destructive methods: instrumental neutron activation analysis with high resolution spectrometry of short-lived radionuclides and inductively coupled plasma atomic emission spectrometry.
Results: It was observed that in TMN tissue the mean mass fraction of I was lower while the mean mass fractions of K, Mg, and P were higher than in both NT and TBN groups of samples. It was demonstrated that I content is nodular tissue is the most informative parameter for the diagnosis of thyroid malignancy. It was found that “Sensitivity”, “Specificity” and “Accuracy” of TMN identification using the I level in the needle biopsy of affected thyroid tissue was significantly higher than that using US examination and cytological test of fine needle aspiration biopsy.
Conclusions: It was concluded that determination of the I level in a needle biopsy of TNs using non-destructive instrumental analytical method is a fast, reliable, and very informative diagnostic tool that can be successfully used as an additional test of thyroid malignancy identification.
Prediction for the Progression of Chronic Kidney Disease (CKD) in Various Situations
Authors: BANDO Hiroshi
Published: January 2023

The discussion of chronic kidney disease (CKD), kidney replacement therapy (KRT), and end-stage kidney disease (ESKD) has been important. Recently, a useful predictive model of CKD progression to renal failure was reported by the German CKD study group. They include a novel 6-variable risk score (Z6), composed of creatinine, albumin, cystatin C, urea, hemoglobin, and urinary alb/cre ratio (UACR). CKD patients were studied in 3 groups based on educational attainment. Hazard ratios compared to low vs high groups showed mortality of 1.48, MACE 1.37, and renal failure 1.54, respectively. For the prediction of CKD progression, UACR and estimated glomerular filtration rate (eGFR) are useful.
Latest Standard Management for Heart Failure with Guideline-Directed Medical Therapy (GDMT)
Authors: BANDO Hiroshi
Published: January 2023

Sodium–glucose cotransporter 2 inhibitor (SGLT2i) has been attracting attention for novel agent for patients with diabetes and also heart failure (HF), in which the left ventricular ejection fraction (LVEF) has decreased. For standard cardiovascular treatment, 2022 AHA/ACC/HFSA Guideline for the Management of Heart Failure is recently presented. Some important perspectives were found, which are HF with mildly reduced EF (HFmrEF), HF with improved EF (HFimpEF) and HF with preserved EF (HFpEF). For patients with HFmrEF, SGLT2i can contribute reducing HF hospitalizations and cardiovascular death. From now, the guideline-directed medical therapy (GDMT) will contribute the standard and beneficial therapy.
COVID Pneumonia with Immune Thrombocytopenic Purpura and Some Novel Strange Graduated Electrocardiographic T-Wave Abnormalities, Clinical Impact and Interpretation
Authors: Hassanain Elsayed Yasser Mohammed
Published: January 2023

Rationale: Immune thrombocytopenic purpura may be associated with severe acute respiratory syndrome (SARS) or Coronaviruses. Probably fatal outcome for the disease has a remarkable effect on morbidity and mortality. T-wave is the positive deflection post-each QRS-complex. Physiologically, it represents ventricular repolarization.
Patient Concerns: A 66-year-old, teacher, married male, Egyptian patient was presented to the physician outpatient clinic with COVID-19 pneumonia with thrombocytopenia and abnormal T-wave.
Diagnosis: COVID pneumonia with immune thrombocytopenic purpura and novel T-wave graduation.
Interventions: Non-contrast chest CT, electrocardiography, oxygenation, and echocardiography.
Outcomes: Good response and better outcomes despite the presence of numerous remarkable risk factors were the results.
Lessons: The association of COVID pneumonia with immune thrombocytopenic purpura and novel T-wave graduation is highly interesting. An elder age, male sex, COVID-19 pneumonia, and immune thrombocytopenic purpura are constellation serious risk factors. Touching radiological variant pericardial injury with mild hypokalemia maybe interpret the novel T-wave graduation.
Znaczenie miejsca w biografii jednostki
Authors: Kutyła Małgorzata
Published: January 2023

Zdaniem Yi–Fu Tuana miejsce zamyka przestrzeń, kreując w ten sposób wnętrze oraz część zewnętrzną. Miejsce to lokalizacja, w której jednostka zaznaje swojej egzystencji zatem doświadczenie miejsca stanowi naturalne doświadczenie człowieka. Niepowtarzany klimat miejsca, jego atmosfera oraz charakter przesądza o losach indywidualnych i społecznych jednostki. Decyduje o nierozerwalności osoby i świata. W rezultacie stanowi o integralności, która jest zrozumiała ludzkiemu poznaniu, zaradności, aktywności a także poświęceniu i pasji. Znaczenie miejsca stanowi nie tylko efekt zmysłowego doświadczenia lecz również funkcji pragmatycznych. Celem artykułu jest opisanie jakie jest znaczenie miejsca w życiu jednostki. Podstawowym materiałem do analizy jest wywiad narracyjno-biograficzny przeprowadzony z Panem Antonim, który swoje dorosłe życie związał z miastem Tarnobrzeg, w związku z rozwojem przemysłu siarkowego. Dla Narratora stanowi ono centrum jego dorosłego życia, wypełnionego bogactwem osobistych doświadczeń i wspomnień. Własne miejsce zamieszkania jest obdarzone znaczeniem niezależnie od jego czasu historycznego bądź społecznego.
Penerapan Model Problem Based Learning (PBL) untuk Meningkatkan Hasil Belajar Aritmetika Sosial Kelas VII-F SMP Jembatan Budaya
Authors: Aryasih Ni Wayan Parni
Published: January 2023

Matematika untuk SMP disajikan dengan lebih banyak materi dan tentu saja lebih rumit karena pembelajaran lebih menekankan pada pemecahan masalah. Dalam pembelajaran matematika materi aritmetika sosial siswa kelas VII F SMP Jembatan Budaya masih banyak siswa yang belum tuntas (dibawah KKM 66). Oleh karena itu perlu suatu upaya dan tindakan untuk meningkatkan hasil belajar matematika siswa dengan penerapan model problem based learning. Dalam Penelitian ini bertujuan untuk mengetahui peningkatan hasil belajar siswa kelas VII F SMP Jembatan Budaya melalui penerapan model problem based learning pada materi aritmetika sosial. Subyek dalam penelitian ini adalah siswa kelas VII F SMP Jembatan Budaya yang berjumlah 24 orang, terdiri dari 8 orang siswa perempuan dan 16 orang siswa laki-laki. Untuk menganalisis hasil penelitian, data yang dkumpulkan meliputi hasil belajar siswa dan hasil observasi guru. Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang dilaksanakan dalam dua siklus. Tiap siklus meliputi 4(empat) tahap yaitu perencanaan, pelaksanaan tindakan,  observasi dan Evaluasi serta refleksi. Pada penelitian ini tindakan dikatakan berhasil apabila sekurang-kurangnya 85% siswa memperoleh nilai ≥ 66. Berdasarkan analisis  tindakan yang dilakukan dalam penelitian  hasil dalam penelitian ini menunjukkan: (1) Ketuntasan belajar siswa pada siklus I sebesar 62,50% dengan nilai rata-rata 68,41 dan pada siklus II ketuntasan belajar siswa sebesar 87,50% dengan nilai rata-rata 77,91 (2) Skor aktivitas siswa pada siklus I sebesar 70% dan pada siklus II    sebesar 84%. Dari hasil yang diperoleh tersebut menunjukkan bahwa pada siklus I hasil belajar belum sesuai harapan yang berarti indikator keberhasilan belum tereapai sedangkan pada siklus II hasil belajar sudah sesuai harapan yang berarti indikator keberhasilan sudah tercapai.
Penggunaan Pendekatan Realistic Mathematics Education (RME) Terhadap Peningkatan Kemampuan Pemahaman Konsep Matematis Siswa
Authors: Nurdini Sophi
Published: January 2023

Pembelajaran matematika yang dikenal sebagai mata pelajaran yang kurang di senangi oleh siswa, menjadi cenderung monoton membuat siswa merasa jenuh, pemahaman siswa pun berkurang terhadap pelajaran matematika oleh karena itu guru harus bisa mencari solusi dengan memilih pendekatan pembelajaran yang direncanakan akan tercapai. Pendekatan pembelajaran yang mungkin dapat digunakan untuk meningkatkan kemampuan pemahaman konsep matematis adalah Realistic Mathematics Education (RME). Penelitian ini merupakan penelitian eksperimen yang bertujuan untuk mengetahui apakah 1) Kemampuan Pemahaman Konsep matematis siswa yang memperoleh Realistic Mathematics Education (RME) lebih baik daripada siswa yang memperoleh pembelajaran Ekspositori, serta untuk mengetahui apakah 2) Sikap siswa terhadap pembelajaran Realisic Mathematics Education (RME). Populasi penelitian ini adalah siswa SMP adapun sampel dalam penelitian ini adalah siswa kelas VII SMPN 20 Bandung terpilih secara acak menurut kelas. Instrumen yang digunakan berupa tes berbentuk uraian dan skala sikap. Hasil penelitian ini adalah: 1) Penggunaan model Realistic Mathematics Education (RME) berpengaruh positif terhadap peningkatan kemampuan pemahaman konsep matematis siswa dan 2) Siswa bersikap positif terhadap model Realistic Mathematics Education (RME) dalam pembelajaran matematika.
Peningkatan Hasil Belajar IPA Materi Rangkaian Listrik Melalui Penerapan Metode Eksperimen di Kelas VI Sekolah Dasar Negeri Pakualam 01 Tahun Pelajaran 2019/2020
Authors: Sari Mimien Dwi Anita
Published: January 2023

Penelitian ini merupakan Penelitian Tindakan Kelas (PTK) yang bertujuan untuk mengetahui hasil belajar IPA materi rangkaian listrik melalui penerapan metode eksperimen pada siswa kelas VI SDN Pakualam 01 Tahun Pelajaran 2019/2020. Penelitian ini dilakukan secara kolaboratif dan partisipasif yang dilaksanakan dalam dua siklus. Pengumpulan data dalam penelitian ini dilakukan dengan menggunakan observasi partisipa, wawancara dan tes tertulis. Hasil belajar siswa setelah menggunakan metdoe ekserimen mengalami peningkatan yaitu pada saat pra siklus, ketuntasan siswa hanya 25%, setelah dilaksanakan siklus I persentase ketuntasan kemampuan belajar siswa sebesar 62,5% kemudian pada tindakan siklus II, ketuntasan kemampuan belajar mencapai 90,63%. Penggunaan metode eksperimen juga dapat meningkatkan indokator kemampuan belajar siswa kelas VI SDN Pakualam 01 Tahun pelajaran 2019/2020 . Minat belajar siswa terdiri dari tekun, ulet dan disiplin. Pada siklus I minat belajar siswa memperoleh skor akhir 60%, artinya minat belajar siswa berada pada kriteria baik. Pada siklus II skor akhir minat belajar siswa mencapai 92,5% sehingga berada pada kriteria sangat baik. Berdasarkan hasil penelitian disimpulkan bahwa penggunaan metode eksperimen dapat meningkatkan kemampuan belajar siswa. Hal ini didukung dengan data penelitian yang menunjukkan adanya peningkatan persentase ketuntasan di setiap siklusnya.
Peningkatan Motivasi dan Hasil Belajar Matematika pada Materi Turunan Fungsi Aljabar Kelas XII TKJ 2 Melalui Metode Drill di SMKS NU BODEH
Authors: Pujiasih Tri
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan motivasi dan hasil belajar matematika pada materi turunan fungsi aljabar kelas XII TKJ 2 melalui metode  drill di SMKS NU BODEH. Subjek penelitian adalah 14 peserta didik. Subjek pelaksana tindakan adalah peneliti sebagai observer. Teknik pengumpulan data melalui teknik observasi, dokumentasi dan tes. Teknik analisis data yang digunakan adalah deskriptif komparatif. Hasil penelitian ini menunjukkan adanya sebuah peningkatan motivasi belajar dan hasil belajar matematika pada materi turunan fungsi aljabar kelas XII TKJ 2 melalui metode drill. Hal ini dapat dilihat dari peningkatan motivasi belajar peserta didik kelas XII TKJ 2 sebelum tindakan rendah, siklus I kategori sedang sebanyak persentasenya 50%, dan pada siklus II kategori tinggi sebanyak persentasenya 85%. Untuk hasil belajar peserta didik kelas XII TKJ 2 pada materi turunan fungsi aljabar meningkat, sebelum tindakan hasil belajar peserta didik yang mencapai KKM (≥70) sebanyak 3 peserta didik atau persentase ketuntasan sebanyak 21,4%, siklus I sebanyak 7 siswa atau 50%, pada siklus II sebanyak 12 peserta didik atau 85,7%. Penelitian ini menyimpulkan bahwa penggunaan metode drill dapat meningkatkan motivasi belajar dan hasil belajar matematika pada materi turunan fungsi aljabar kelas XII TKJ 2 Semester Genap Tahun Pelajaran 2018/2019.
Peningkatan Motivasi dan Hasil Belajar Matematika Melalui Model Pembelajaran Creative Problem Solving (CPS) Dengan Berbantuan LKS Pada Materi Turunan Fungsi Aljabar Bagi Siswa Kelas XII AKL 1 Semester II SMKS NU Bodeh Kabupaten Pemalang Tahun Pelajaran 2
Authors: Mitafiana Vika
Published: January 2023

Penelitian ini bertujuan untuk meningkatkan Motivasi belajar dan hasil belajar siswa muatan pelajaran Matematika dengan model pembelajaran Problem Solving berbantuan LKS pada siswa kelas XII AKL 1 SMKS NU Bodeh. Subjek penelitian adalah 14 siswa, Subjek pelaksana tindakan adalah peneliti sebagai observer. Data diambil dengan lembar observasi keaktifan dan kerjasama serta hasil tes akhir. Instrumen penelitian berupa pengujian soal Turunan Fungsi Aljabar yang telah diuji validitas, reabilitas, daya pembeda dan tingkat kesukarannya dengan menggunakan teknik deskriptif melalui prosentase dan hasil belajar siswa dengan menghitung rata-rata nilai dan ketuntasan belajar baik individu maupun klasikal. Hasil penelitian ini adalah menunjukkan adanya sebuah peningkatan motivasi belajar dan hasil belajar muatan pelajaran Matematika pada siswa kelas XII AKL 1 melalui model Problem Solving berbantuan LKS hal ini dapat dilihat dari peningkatan motivasi belajar siswa kelas XII AKL 1 sebelum tindakan rendah, siklus I kategori Sedang sebanyak persentasenya 55%, dan pada siklus II katagori tinggi sebanyak persentasenya 88%. Untuk hasil belajar siswa kelas XII AKL 1 pada muatan pelajaran Matematika meningkat, sebelum tindakan hasil belajar siswa yang mencapai ketuntasan belajar sebanyak 2 siswa atau persentase ketuntasan sebanyak 14%, siklus I sebanyak 7 siswa atau 50%, pada siklus II sebanyak 13 siswa atau 92%. Penelitian ini menyimpulkan bahwa penggunaan Model Problem Solving berbantuan LKS dapat meningkatkan motivasi belajar dan hasil belajar muatan pelajaran Matematika pada materi turunan fungsi aljabar bagi siswa kelas XII AKL 1 Semester II SMKS NU Bodeh Tahun Pelajaran 2018/2019.
Retaining the Mother Tongue while Learning Host Country’s Languages. A Study with Second Generation Sudanese Immigrant Children
Authors: Mohammed Abdulghani Eissa Tour
Published: January 2023

Sadly, the destination of some vital national languages has been buried with their speakers during the whole death trips by land and sea, with the topic of migration affecting a lot of international and local news stations. The present study investigates the difficulties confronting Sudanese immigrant children when communicating in some indigenous languages besides learning the host countries' languages. Most participants in the current study are multilingual Sudanese immigrants from areas and intense conflict zones such as Darfur, Blue Nile, and South Kordofan. The real issue is how immigrants who make it to their intended destinations preserve their home tongues and cultural traditions as sources of identity. The researcher employed a qualitative research methodology to carry out this investigation. An initial 58 Sudanese immigrants were interviewed. The study found that (1) it might be challenging to communicate with kids even though parents speak these languages at home. (2) this situation may decrease the number of those who speak these national languages and will result in losing the national identity of future generations in the diaspora unless this situation changes, (3) children of Sudanese immigrants in the diaspora learn primarily the host country language, in addition to their indigenous languages based on the data collection and analysis. It is recommended that parents should use their local language continually at home with their children to preserve their identity and cultural heritage.
Peculiarities of manifestation and general rehabilitative signif icance of the phenomenon paradoxical kinesia in Parkinson’s disease
Authors: Bogdanova Iryna , Voloshyna Natalia , Fedosieiev Serhii , Voloshyn-Gaponov Ivan , Tereshchenko Liudmyla , Bogdanova Taisia
Published: January 2023

The purpose of the study: is to identify the factors contributing to the occurrence of paradoxical kinesias (PK) in Parkinson’s disease (PD) and to assess their frequency and clinical manifestations (according to the results of interviews). All patients interviewed were divided into two groups. The first group (45 people) — patients without symptoms of dementia, the second group (18 people) — patients with symptoms of dementia. The MMSE assessment was conducted no more than three months before this survey to assess the frequency of PK phenomenon, before the introduction of quarantine restrictions. Patients with PD initially have virtually no idea about the phenomenon of PK, but when informed (individually and in groups) in a group of patients without clinically significant cognitive decline, understanding of the essence and possibilities of PK increases from 6.7% to 88.9% of respondents. Patients with PD, cognitively preserved, note the manifestations of PK in the form of a spontane- ous ability to perform movements faster and more dexterously in 82.2% of observations, with vital movements of posture control, walking, and balance observed in 93.3% of patients, and the per- formance of complex acts in 51.1% of observations. Factors contributing to the manifestation of PK are often (in more than 50.0% of cases) in the group of patients without significant cognitive decline is - rhythm, counting, cues (84.4%), listening to music (93.3% of answers), environment (64.4%), strong emotions (93.3%); communication with certain people (88.9 %; answers); quality of sleep (80.0 %); less frequent, but practically applicable are internal order and conscious control (48.9 %) and visualization of the motor act (40.0 %). The realization of the phenomenon of PK with the help of factors that reveal it can be used in conducting classes on motor rehabilitation, but it is necessary to preserve the cognitive poten- tial of patients. The rehabilitation potential of patients with PD is defined as medium or low level. This level of rehabilitation potential is generally sufficient for the implementation of the developed individual rehabilitation programs.
Vegetative and cerebrovascular regulation in vestibular dysfunctions of ischemic origin
Authors: Mashchenko Serhii , Stoianov Oleksandr , Kalashnikov Valerii , Vastianov Ruslan , Andreyeva Tamara , Oliinyk Svitlana
Published: January 2023

Vestibular dysfunction (VD) is a common syndrome of ischemic brain damage that occurs with pronounced vegetative accompaniment, cerebrovascular regulation disorder. 62 patients with VD on the background of chronic brain ischemia in the compensated (I group n = 24) and subcompensated (II group n = 38) stages were examined (40.3 % men; 59.7 % women), age from 18 to 55 years, average age was 38.6 ± 1.6 years. In case of ischemic damage to the brain due to degenerative-dystrophic changes in the cerebral cortex, certain mechanisms of the development of VD with dizziness have been registered. Their presence in the clinical picture of vascular dyshemia correlates with the degree of damage, is ac- companied by pain, as well as associated complaints and symptoms. Vestibulo-atactic disorders, recorded using the integrative state of statolocomotor, were elevated compared to healthy subjects, and further increased depending on the degree of brain damage, especially against the background of prevailing vagotonia in most patients. Autonomic dysfunctions are an important aspect of the development of VD. The obtained data indicate that VD develops against the background of pathological autonomic characteristics with predominant parasympathetic orientation of vegetative tone, especially in the case of insufficiency of vegetative reactivity and pathological vegetative maintenance of activity. Such changes significantly (p < 0.05) increased in the presence of subcompensation of the chronic brain ischemia. Psychoemotional and cognitive disorders are comorbid according to the changed autonomic characteristics in VD on the background of chronic brain ischemia with initial patterns depending on the degree of brain damage. A characteristic hemodynamic feature in the groups with compensated and subcompensated chronic brain ischemia is the presence of reduced perfusion in main artery and vertebral artery. Significant changes in cerebral vascular reactivity along the myogenic circuit with a decrease in KrO2 and KrFNT indicators are a characteristic feature of the subcompensated stage of chronic brain ischemia. Hyperreactivity on rotational functional loads in both clinical groups has a high correlation with the presence of staircase and, to a lesser extent, isolated instability.
Media and National Issues: Exploring Political Parallelism in Leading Pakistani Newspapers
Authors: Gul Zarmina , Siraj Dr. Syed Abdul
Published: January 2023

In political communication, media content is often parallel to political discourse. This content analysis study aims to determine whether and to what extent political parallelism exists in the coverage of major national issues published in the leading English newspapers of Pakistan. In order to identify the existence of High and Low forms of political parallelism reflected in the media content. Many parameters, such as media pluralism, media sociology, and media instrumentalization, determine existence of political parallelism in media. This study selected 11 national issues from Pakistan’s leading dailies from 1 January 2020 to 31 December 2020. The major findings revealed that political parallelism appears in selection of media content. Furthermore, the study concludes that besides politicians and industrialists, the government is also one of the influencing factors that encourage political parallelism in Pakistan.
Keywords: National Issues, Political Parallelism, Media, Government, Opposition, Political Parties, Judiciary
Effect of Depression on Sleep Quality and Pain among Patients with Arthritis Disease
Authors: Shaheen Nighat , Arzeen Saima , Batool Sidra
Published: January 2023

The major aim of the present study was to examine the effect of depression on sleep quality and pain among patients with arthritis. The sample included (N=30) arthritis female patients recruited from outpatients of three main hospitals of Peshawar using Convenient Sampling Technique. Age range of the sample was between 45 to 65 years (M=54.51 ± 5.24). The inclusion criteria consisted of patients having diagnosed with hip and/or knee arthritis since one year on the basis of X-rays reports and currently were under treatment. The control group consisted of (N=26) female outpatients in the same age range who visited the OPD of the same hospitals for their less severe diseases. The Siddiqui Shah Depression Scale (Siddiqui & Shah, 1997) was used to measure depression, the Pittsburgh Sleep Quality Index (Buysse, Reynolds, Monk, Berman, & Kupfer, 1989) was used to assess quality of sleep and the Visual Analogue Scale (Gracely, McGrath, Dubner, 1978) was used to obtain data on the severity of pain in participants. Results showed that participants having higher baseline depression obtained significantly higher mean scores on the SSDS, the PSQI, and the VAS scales compared to the control group. The results support all hypotheses of the study. The findings have critical implications in clinical setting by suggesting an utmost need of treatment of the depression in arthritis patients in order to overcome their problem of sleep and reducing intensity of pain.
Key Words: Depression, Sleep Quality, Pain, Arthritis
Analisis Citra Merek dan Kepuasan Pelayanan terhadap Loyalitas Konsumen Pengguna Aplikasi Pesan antar Makanan
Authors: Mustangin Mustangin , Tukirin Tukirin , Wibowo Edi Wahyu , Sugianto Eko , Estiana Ria
Published: January 2023

Perusahaaan jasa pesan antar makanan tumbuh berkembang tetapi perlu meningkatkan kinerjanya agar konsumen selalu memiliki loyalitas. Dalam penelitian ini akan menganalisis pengaruh citra merk dan kualitas pelayanan terhadap loyalitas konsumen pengguna aplikasi pesan antar makanan di Jakarta dengan jumlah responden 100 orang dan menggunakan metode kuantitatif serta menggunakan alat ukur PLS 4.0. Hasil penelitian ini menyatakan bahwa Variabel citra merk tidak berpengaruh terhadap loyalitas konsumen pengguna aplikasi pesan antar makanan di Jakarta. Meskipun hasil penelitian ini menyatakan konsumen belum memiliki loyalitas dari segi citra merk, diharapkan penyedia aplikasi pesan antar makanan dapat membuat program brand activation sehingga merk nya bisa lebih terkenal dan juga memiliki nilai positif. Variabel kualitas pelayanan berpengaruh terhadap loyaltas konsumen pengguna aplikasi pesan antar makanan di Jakarta. Meskipun sudah baik, tetapi dapat ditingkatkan kualitas pelayanan menjadi lebih baik lagi melalui program garansi tepat waktu, agar konsumen semakin yakin terhadap kualitas pelayanan perusahaan penyedia aplikasi pesan antar makanan ini.
Analisis Perkembangan Usaha Pabrik Roti Reyhan terhadap Pemberdayaan Masyarakat di Wilayah Kelurahan Batu Ampar
Authors: Narsih Dwi
Published: January 2023

Tujuan penelitian ini adalah untuk mengetahui pengaruh perkembangan usaha pabrik roti Reyhan terhadap pemberdayaan masyarakat guna menambah pendapatan masyarakat di wilayah kelurahan Batu Ampar. Pada penelitian ini, menggunakan metode penelitian kualitatif. Pendekatan yang akan digunakan dalam penelitian ini adalah pendekatan deskriptif. Teknik pengumpulan data pada penelitian ini dengan cara melakukan observasi, wawancara (interview) dan  dokumentasi. Teknik pengambilan sample pada penelitian ini menggunakan Teknik purposive sampling Populasi dari penelitian ini adalah masyarakat yang berada pada lingkungan pabrik roti Reyhan di RT 03 RW 04 Kelurahan Batu Ampar Teknik analisis data yang digunakan reduksi data, penyajian data, penarikan kesimpulan/verifikasi. Pabrik roti Reyhan dapat memberdayakan  masyarakat dengan mempekerjakan masyarakat dari RT 03. Hal tersebut menunjukkan bahwa pabrik roti Reyhan dikatakan berhasil dalam memberdayakan masyarakat sehingga masyarakat sekitar RT 03 RW 04 dapat bekerja dan menghasilkan yang akan digunakan untuk memenuhi kebutuhan hidupnya. Dalam proses pemberdayaannya, karyawannya diberikan pelatihan agar dapat memiliki kemampuan baru yang nantinya akan berguna untuk kedepannya jika ingin membuka usaha sendiri dan juga pabrik roti Reyhan tidak melihat latar belakang dari karyawannya untuk dapat bekerja di pabrik roti Reyhan.
THE LATEST TRENDS IN THE CREATION OF IMPACT-VIBRATION EQUIPMENT WITH DIFFERENT TYPES OF DRIVES FOR SOIL PROBING
Authors: Veselovska Nataliia
Published: January 2023

The study of soils by immersion of a cone under the influence of ultrasonography is one of the express methods of obtaining engineering and geological information about the physical and mechanical properties of the foundation from loose soils of buildings and structures. It makes it possible to detect the degree of homogeneity of probed soils; determine the position of the boundaries (contacts) of various lithological layers and bearing layers for the fuel base; to identify and delineate in plan and in depth the weakened zones on the studied areas for the exact reference of the place of conducting experimental works; choose the optimal options for choosing hammers; evaluate the physical and mechanical properties of sandy soils (density, angle of internal friction, etc.); roughly estimate the modulus of deformation of sandy soils.
The main tasks are the development, research and calculation of the main parameters of installations with a hydraulic impulse drive for soil probing.
The object of research is the process of soil probing. The subject of the study is the hydropulse drive of the soil probing installation.
Experience has shown that the effective use of field methods is possible only under the condition of a methodically correct approach to the preparation and execution of programs of the entire complex of search operations. Various aspects of the problem of comprehensive soil research using field methods were developed and deepened gradually.The main research methods include the analysis of information on existing methods and installations for spraying tungsten powders, mathematical modeling of processes in the spindle unit of the installation for spraying metal powders, taking into account its design features and operating modes based on nonlinear differential equations of heat transfer from solid and liquid bodies using numerical methods of their solution based on the FlowVision program.
STUDY OF AN ENERGY-SAVING DIE FOR RADIAL REDUCTION
Authors: Gaidamak Oleg
Published: January 2023

Reducing the power of forging and pressing equipment is an important task of modern metal forming technologies. The article is devoted to the development and research of dies capable of significantly (tens or more times) reducing the power of the used forging and pressing equipment due to the use of energy-saving dies that can significantly increase the deforming force. A stamp capable of significantly increasing the deforming force is called energy-saving . The article shows that using different types of levers, it becomes possible to significantly increase the useful force of stamping tools acting on a deformable workpiece. Thus, it becomes possible to use relatively low-power pressing equipment to achieve significant forces of the working tool. Based on the given mathematical dependences of the geometric and power characteristics of the energy-saving stamp, a computer program was developed in MS Excel and modeling was carried out, with the help of which it was studied how the deforming force R changes depending on the change in the angle of inclination of the punches  and the corresponding graph was plotted at a predetermined constant pushing force F = 1 N. After analyzing the resulting graph, it can be argued that a tenfold increase in the deforming force R compared to the pushing force F, which is created by the pressing equipment, is observed at an angle of  = 5.35 degrees, fifty times at an angle of 1.1 degrees. At angles approaching 0 degrees, the increase in the deforming force can reach significant values and is limited only by the strength of the energy-saving stamp itself. Calculation formulas are given that allow calculating the main dimensions of the punches and the working stroke of the forging and pressing equipment for a given working stroke of the punches and a given increase in the deforming force. Possible areas of application of the energy- saving stamp are shown.
THERMAL POWER TECHNOLOGY OF NEW GENERATION CONCRETE
Authors: Shvets Ludmila , Yakivchuk Serhii
Published: January 2023

Over the last decade, the trend of producing monolithic concrete and reinforced concrete with increased strength indicators continues in Ukraine and the world. Ensuring the performance of concrete and short roads is one of the main tasks of the technology of reinforced concrete products in modern times.
It is known that thermoforce processing can have a positive effect on the properties of concrete - such as volume, strength, corrosion resistance, water permeability, durability. In these industrially developed countries, the use of concrete with increased physical and mechanical indicators is growing.
In the construction industry, there is a problem of saving money and energy security. The application of the thermoforce method for the production of new-generation concrete allows to increase the indicators of strength, corrosion resistance and other physical and mechanical properties of concrete.
In conditions of high competition in the production of concrete products, obtaining high-strength concrete by using high-quality aggregates and binders of high grades sharply increases the cost of the product and makes it uncompetitive. There is a problem related to the reduction in the production of high-quality binders and aggregates due to the extraction of quality raw materials. Most of the quarries, where quality raw materials for the construction industry were mined, are abandoned or exhausted. Therefore, it is necessary to identify internal reserves of concrete strength growth, to solve the acute problem of saving resources and energy saving, using ordinary components and local building materials. It is possible to significantly open the strength reserves of concrete and increase the physical and mechanical properties of concrete through the complex influence of such factors as vibration, excess pressure, temperature and chemical additives.
CONTROL OF ASYNCHRONOUS AC ELECTRIC MOTOR ACCORDING TO THE PRINCIPLE OF CONSTANT V/F AND CONVENTIONAL PWM CONTROL
Authors: Voznyak Oleksandr , Shtuts Andrii
Published: January 2023

The principle of operation of any automatic control system is to detect deviations of regulated values from set values and to form influences on the control process to eliminate these deviations. Often, a variable value whose value must be maintained constantly or changed according to the desired law is called a controlled value (coordinate). It is customary to call the required value of the regulated value (coordinate) set, and the actual value - current. The difference between the setpoint and the actual value is a deviation or error signal. A set of devices that affect the object of control, maintaining the current value of the controlled quantity (coordinate) equal to the given one, is called an automatic regulator or a dynamic system.
The influence of the regulator on the object with the aim of bringing the current value of the controlled value closer to the set value (or adding the desired properties to the closed system) is called the control influence, and the set of devices and physical environments through which the control influence acts on the controlled value is called the control channel.
The control process carried out by the regulator manifests itself in a change in the set value of the regulated quantity or a deviation of at least one of the unregulated quantities that affect the regulated one through feedback circuits. A change in the set value of an adjustable quantity is called a controlling or internal setting influence, and a change in unregulated quantities is called an external disturbance. The principle of deviation control is to compare the set value of the regulated value (setting) with its current value. In this case, the error signal Δ is used to create such a regulatory influence on the control object that this error, regardless of the reasons that caused it, does not go beyond the permissible values.
In order to protect the environment and reduce the effect of greenhouse gas emissions, regulations are being introduced all over the world that require manufacturers of household electrical equipment and industrial enterprises to produce products that use electricity more economically. Most often, this can be achieved by effectively controlling the speed of the electric motor. This is the reason why consumer appliance developers and semiconductor suppliers are now interested in developing low-cost and economical adjustable actuators.
DEVELOPMENT OF AN INSTALLATION FOR THE PRODUCTION OF ELECTRICITY AND WATER SUPPLY WITH WIND DRIVE
Authors: Shvets Ludmila , Kucherenko Maksym
Published: January 2023

To supply water to the fields, an irrigation system is built, which includes a source of water supply, a water intake structure with a pumping unit, transport, distribution and working channels or pipes. Closed or open irrigation networks are built on the fields. In a closed network, water under pressure is supplied through pipes and hydrants to irrigation machines or installations. The open network is laid in the form of temporary pipelines, channels or trays, from which water is supplied by pumps to sprinklers and watering machines. Near cities and large livestock complexes, fields are irrigated with wastewater, which is also used with fertilizers.
Water is supplied to the soil by sprinkling, surface, and subsoil and drip irrigation. Water is broken into drops and distributed over the irrigated area in the form of rain. The size of the drops should not exceed 1...2 mm. Rain intensity should be no more than 0.1...0.2 mm/min for heavy soils, 0.2...0.3 mm/min for medium loams, 0.5...0.8 mm/min for light soils. Under such conditions, raindrops do not damage plants, compact the soil less and do not destroy soil clods, water has time to soak into the soil, and puddles do not form on the surface of the soil. It is important to evenly distribute water over the irrigated field and ensure the specified irrigation rate. Fertilizers are applied at the same time as watering.
Water is also supplied in furrows, in strips or by flooding the entire irrigated area. When irrigating the subsoil, water is fed into the soil through pipes with holes, through mole holes located at a depth of 40...50 cm. Through soil capillaries, water rises into the upper layers of the soil. This method is not recommended for use on sandy and loamy soils.
Proposed design of a wind-driven power generation and water supply installation.
CAUSE-EFFECT RELATIONSHIPS OF THE PARAMETERS OF THE MAIN RESOURCE GROUPS OF YAMZ-236/238 ENGINES
Authors: Dmytro Borysiuk Dmytro Borysiuk , Viacheslav Zelinskyi Viacheslav Zelinskyi , Anatoly Spirin Anatoly Spirin , Tverdokhlib Igor
Published: January 2023

Constructive improvement of mobile energy vehicles, in particular their main unit – the internal combustion engine, is aimed at: ensuring the differentiation of the parameters of the functioning of the system mechanisms depending on the variability of the conditions and modes of operation of the machines; increasing the technical resource when using the machines as intended in the specified operating conditions.
During the analysis of literary sources, it was established that the existing methods and means of diagnosing vehicle engines do not fully allow determining their current technical condition, which requires the development of mathematical models for automating the process of diagnosing their components and parts.
Internal combustion diesel engines of the YaMZ-236/238 family, which are included in the power units of most tractors and cars, were chosen as the object of diagnosis.
The use of modern non-contact and non-disassemble diagnostic methods based on the analysis of the initial parameters of the diesel engine, functionally related to its structural parameters, will allow solving the task of reducing the labor intensity of the work, the quality of diagnostics, however, they are not sufficiently researched. Therefore, to determine the technical condition of engines, it is necessary to use modern non-contact and non-destructive diagnostic methods, which are based on the analysis of initial parameters functionally related to structural parameters.
The article presents the cause-and-effect relationships of the parameters of the main resource groups of internal combustion diesel engines of the YaMZ-236/238 family. A graph-model of the interrelationships of the controlled parameters of the main resource groups of the YaMZ-236/238 engines and their defects was built.