bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Crystalline Defects Caused by Growth on Partially Planarized Spalled (100) GaAs Substrates
Authors: Boyer Jacob T. , Braun Anna K. , Schulte Kevin L. , Simon John , Johnston Steven W. , Guthrey Harvey L. , Steiner Myles A. , Packard Corinne E. , Ptak Aaron J.
Published: April 2023

We analyze the effect of growth on non-(100) surfaces resulting from incomplete planarization of spalled GaAs wafers on the defect structure of GaAs solar cell layers grown by hydride vapor phase epitaxy (HVPE). Controlled spalling of (100)-oriented GaAs has the potential to reduce substrate costs for III-V epitaxy; however, it creates regularly faceted surfaces that may complicate the growth of high-quality III-V optoelectronic devices. We leverage the anisotropic growth rate of HVPE to planarize these faceted GaAs substrates, reducing the surface roughness and degree of faceting. We observe degraded solar cell performance and material quality in sample areas where facets are not completely removed. We used dark lock-in thermography and photoluminescence to identify recombination in areas that were not fully planarized. We used cathodoluminescence to identify the presence of extended defects in these regions, which are correlated with bandgap fluctuations in the material. We hypothesize that these defects were created by strain from compositional fluctuations in ternary alloys grown on the faceted surfaces. This work elucidates the potential issues of solar cells grown on faceted surfaces and builds understanding toward realizing high performance III-V photovoltaics with the cost-reduction potential of controlled spalling.
High-Performance Nanoplasmonic Enhanced Indium Oxide—UV Photodetectors
Authors: Li Eric Y. , Zhou Andrew F. , Feng Peter X.
Published: April 2023

In this paper, high-performance UV photodetectors have been demonstrated based on indium oxide (In2O3) thin films of approximately 1.5–2 μm thick, synthesized by a simple and quick plasma sputtering deposition approach. After the deposition, the thin-film surface was treated with 4–5 nm-sized platinum (Pt) nanoparticles. Then, titanium metal electrodes were deposited onto the sample surface to form a metal–semiconductor–metal (MSM) photodetector of 50 mm2 in size. Raman scattering spectroscopy and scanning electron microscope (SEM) were used to study the crystal structure of the synthesized In2O3 film. The nanoplasmonic enhanced In2O3-based UV photodetectors were characterized by various UV wavelengths at different radiation intensities and temperatures. A high responsivity of up to 18 A/W was obtained at 300 nm wavelength when operating at 180 °C. In addition, the fabricated prototypes show a thermally stable baseline and excellent repeatability to a wide range of UV lights with low illumination intensity when operating at such a high temperature.
Biophysical Changes of Leukocyte Activation (and NETosis) in the Cellular Host Response to Sepsis
Authors: Sorrells Matt G. , Seo Yurim , Magnen Melia , Broussard Bliss , Sheybani Roya , Shah Ajay M. , O’Neal Hollis R. , Tse Henry T. K. , Looney Mark R. , Di Carlo Dino
Published: April 2023

Sepsis, the leading cause of mortality in hospitals, currently lacks effective early diagnostics. A new cellular host response test, the IntelliSep test, may provide an indicator of the immune dysregulation characterizing sepsis. The objective of this study was to examine the correlation between the measurements performed using this test and biological markers and processes associated with sepsis. Phorbol myristate acetate (PMA), an agonist of neutrophils known to induce neutrophil extracellular trap (NET) formation, was added to whole blood of healthy volunteers at concentrations of 0, 200, and 400 nM and then evaluated using the IntelliSep test. Separately, plasma from a cohort of subjects was segregated into Control and Diseased populations and tested for levels of NET components (citrullinated histone (cit-H3) DNA and neutrophil elastase (NE) DNA) using customized ELISA assays and correlated with ISI scores from the same patient samples. Significant increases in IntelliSep Index (ISI) scores were observed with increasing concentrations of PMA in healthy blood (0 and 200: p < 10−10; 0 and 400: p < 10−10). Linear correlation was observed between the ISI and quantities of NE DNA and Cit-H3 DNA in patient samples. Together these experiments demonstrate that the IntelliSep test is associated with the biological processes of leukocyte activation and NETosis and may indicate changes consistent with sepsis.
Ultrasound Imaging of Thoracolumbar Fascia Thickness: Chronic Non-Specific Lower Back Pain versus Healthy Subjects; A Sign of a “Frozen Back”?
Authors: Pirri Carmelo , Pirri Nina , Guidolin Diego , Macchi Veronica , Porzionato Andrea , De Caro Raffaele , Stecco Carla
Published: April 2023

The thoracolumbar fascia (TLF) plays an important role in lower back pain (LBP). Recent studies have revealed an association between increases in TLF thickness and reduced TLF gliding in patients with LBP. The purpose of this study was to measure and compare by ultrasound (US) imaging the thickness of the TLF at the bilateral L3 level of the lumbar spine in the longitudinal and transverse axes in chronic non-specific LBP and in healthy subjects. A cross-sectional study was performed using US imaging to measure the longitudinal and transverse axes with a new protocol in a sample of 92 subjects: 46 chronic non-specific LBP patients and 46 healthy participants. The findings for TLF thickness revealed statistically significant differences (p < 0.05) in the longitudinal and transverse axes between the two groups. Moreover, in the healthy group, a statistically significant difference was found between the longitudinal and transverse axes (p = 0.001 for left and p = 0.02 for right), which was not evident in the LBP patients. These findings suggest that the LBP patients lost anisotropy of the TLF, with it becoming homogeneously thicker and losing adaptability in the transversal direction. The US imaging evaluation suggests that TLF thickness behavior points out altered fascial remodelling compared to healthy subjects, a sort of “frozen back”.
Cardiac MRI: An Alternative Method to Determine the Left Ventricular Function
Authors: Michler Kerstin , Hessman Christopher , Prümmer Marcus , Achenbach Stephan , Uder Michael , Janka Rolf
Published: April 2023

(1) Background: With the conventional contour surface method (KfM) for the evaluation of cardiac function parameters, the papillary muscle is considered to be part of the left ventricular volume. This systematic error can be avoided with a relatively easy-to-implement pixel-based evaluation method (PbM). The objective of this thesis is to compare the KfM and the PbM with regard to their difference due to papillary muscle volume exclusion. (2) Material and Methods: In the retrospective study, 191 cardiac-MR image data sets (126 male, 65 female; median age 51 years; age distribution 20–75 years) were analysed. The left ventricular function parameters: end-systolic volume (ESV), end-diastolic volume (EDV), ejection fraction (EF) and stroke volume (SV) were determined using classical KfW (syngo.via and cvi42 = gold standard) and PbM. Papillary muscle volume was calculated and segmented automatically via cvi42. The time required for evaluation with the PbM was collected. (3) Results: The size of EDV was 177 mL (69–444.5 mL) [average, [minimum–maximum]], ESV was 87 mL (20–361.4 mL), SV was 88 mL and EF was 50% (13–80%) in the pixel-based evaluation. The corresponding values with cvi42 were EDV 193 mL (89–476 mL), ESV 101 mL (34–411 mL), SV 90 mL and EF 45% (12–73%) and syngo.via: EDV 188 mL (74–447 mL), ESV 99 mL (29–358 mL), SV 89 mL (27–176 mL) and EF 47% (13–84%). The comparison between the PbM and KfM showed a negative difference for end-diastolic volume, a negative difference for end-systolic volume and a positive difference for ejection fraction. No difference was seen in stroke volume. The mean papillary muscle volume was calculated to be 14.2 mL. The evaluation with PbM took an average of 2:02 min. (4) Conclusion: PbM is easy and fast to perform for the determination of left ventricular cardiac function. It provides comparable results to the established disc/contour area method in terms of stroke volume and measures “true” left ventricular cardiac function while omitting the papillary muscles. This results in an average 6% higher ejection fraction, which can have a significant influence on therapy decisions.
Mobile-HR: An Ophthalmologic-Based Classification System for Diagnosis of Hypertensive Retinopathy Using Optimized MobileNet Architecture
Authors: Sajid Muhammad Zaheer , Qureshi Imran , Abbas Qaisar , Albathan Mubarak , Shaheed Kashif , Youssef Ayman , Ferdous Sehrish , Hussain Ayyaz
Published: April 2023

Hypertensive retinopathy (HR) is a serious eye disease that causes the retinal arteries to change. This change is mainly due to the fact of high blood pressure. Cotton wool patches, bleeding in the retina, and retinal artery constriction are affected lesions of HR symptoms. An ophthalmologist often makes the diagnosis of eye-related diseases by analyzing fundus images to identify the stages and symptoms of HR. The likelihood of vision loss can significantly decrease the initial detection of HR. In the past, a few computer-aided diagnostics (CADx) systems were developed to automatically detect HR eye-related diseases using machine learning (ML) and deep learning (DL) techniques. Compared to ML methods, the CADx systems use DL techniques that require the setting of hyperparameters, domain expert knowledge, a huge training dataset, and a high learning rate. Those CADx systems have shown to be good for automating the extraction of complex features, but they cause problems with class imbalance and overfitting. By ignoring the issues of a small dataset of HR, a high level of computational complexity, and the lack of lightweight feature descriptors, state-of-the-art efforts depend on performance enhancement. In this study, a pretrained transfer learning (TL)-based MobileNet architecture is developed by integrating dense blocks to optimize the network for the diagnosis of HR eye-related disease. We developed a lightweight HR-related eye disease diagnosis system, known as Mobile-HR, by integrating a pretrained model and dense blocks. To increase the size of the training and test datasets, we applied a data augmentation technique. The outcomes of the experiments show that the suggested approach was outperformed in many cases. This Mobile-HR system achieved an accuracy of 99% and an F1 score of 0.99 on different datasets. The results were verified by an expert ophthalmologist. These results indicate that the Mobile-HR CADx model produces positive outcomes and outperforms state-of-the-art HR systems in terms of accuracy.
Effect of Pre-Surgical Orthopedic Treatment on Hard and Soft Tissue Morphology in Infants with Cleft Lip and Palate
Authors: Ogino Saki , Kawanabe Hitoshi , Fukui Kazunori , Sone Ryoko , Oyama Akihiko
Published: April 2023

The frequency of cleft lip and palate births in Japan is approximately 0.146%. The study aimed to compare the effects of NAM on restoring nasal morphology and improving extraoral nasal morphology in children with cleft lip and palate in the first stage of treatment using 3D imaging and oral model analysis. The subjects were five infants (37.6 ± 14.4 days old) with unilateral cleft lip and palate. The images taken with the 3D analyzer and oral model used for constructing the NAM at the first examination (baseline) and at the completion of the pre-surgical orthodontic treatment (157.8 ± 37.8 days old) were analyzed. The cleft distance was measured at the upper, middle, and lower points on the 3D images. On the model, the cleft jaw width at the maximum protrusion of the healthy and affected sides of the alveolar bone was measured. After the pre-surgical orthopedic treatment, the measured value on the model decreased significantly by a mean of 8.3 mm from baseline, and the cleft lip width narrowed by an average of 2.8 ± 2.2, 4.3 ± 2.3, and 3.0 ± 2.8 mm at the upper, middle, and lower points of the cleft, respectively. Pre-surgical orthopedic treatment using NAM can help narrow the width of the cleft jaw and lip. The sample size is stated at the study limit in the paper.
Image Inpainting with Parallel Decoding Structure for Future Internet
Authors: Zhao Peng , Chen Bowei , Fan Xunli , Chen Haipeng , Zhang Yongxin
Published: April 2023

Image inpainting benefits much from the future Internet, but the memory and computational cost in encoding image features in deep learning methods poses great challenges to this field. In this paper, we propose a parallel decoding structure based on GANs for image inpainting, which comprises a single encoding network and a parallel decoding network. By adding a diet parallel extended-decoder path for semantic inpainting (Diet-PEPSI) unit to the encoder network, we can employ a new rate-adaptive dilated convolutional layer to share the weights to dynamically generate feature maps by the given dilation rate, which can effectively decrease the number of convolutional layer parameters. For the decoding network composed of rough paths and inpainting paths, we propose the use of an improved CAM for reconstruction in the decoder that results in a smooth transition at the border of defective areas. For the discriminator, we substitute the local discriminator with a region ensemble discriminator, which can attack the restraint of only the recovering square, like areas for traditional methods with the robust training of a new loss function. The experiments on CelebA and CelebA-HQ verify the significance of the proposed method regarding both resource overhead and recovery performance.
Design of High-Precision Terahertz Filter Based on Directional Optimization Correction Method
Authors: Yu Weihua , Zhang Lidi , Liu Songzhuo , Gao Gang , Peng Hong , Lv Xin
Published: April 2023

The directional optimization correction (DOC) method is proposed to reduce the performance error between desired and fabricated terahertz (THz) devices. Three 340 GHz terahertz filters with a bandwidth of 20 GHz are designed and fabricated. The traditional global optimization correction (GOC) method and the proposed DOC method are used to optimize and reduce the performance error, respectively. It is garnered that the center frequency error and bandwidth error of the fabricated terahertz filter optimized by the GOC method are reduced to 3.5 GHz (~1.03%) and 2.2 GHz (~11%), respectively. Meanwhile, the center frequency error and bandwidth error of the fabricated terahertz filter optimized by the DOC method are reduced to 0.2 GHz (~0.06%) and 0.4 GHz (~2.0%), respectively, which has fewer optimization parameters and higher accuracy than the GOC method. Furthermore, the in-band return loss (RL) of two optimized terahertz filters based on the DOC and GOC methods is less than 15 dB, and the in-band insertion loss (IL) is less than 2.3 dB.
PFDCT: An Enhanced Transport Layer Protocol for Precise Flow Control in Data Centers
Authors: Li Zhuo , Wang Huiyan , Yi Xiangdong , Zhang Xinyi , Wu Jiawen , Zhang Yubin , Luo Peng , Liu Kaihua
Published: April 2023

This paper proposes an enhanced transport layer protocol for precise flow control in data centers, referred to as PFDCT, combining explicit rate control (priority scheduling) and implicit rate control (marking algorithm with dynamic threshold) innovatively, while satisfying the transmission requirements of each data flow. It enables multiple data flows to share the bandwidth fairly, which is rarely achieved by previous data transmission protocols. Our design stems from the observation that different packets in a data center network need to be processed differentially and that the accuracy of the feedback of the indication information to the link state will directly affect the effectiveness of the congestion control mechanism. Our tests show that PFDCT has lower network jitter, better fairness, and significant performance gains over existing proposals (DCTCP, ICTCP, and L2DCT) in terms of Flow Completion Time (FCT) and throughput on average. Furthermore, we discussed the impact of the marking algorithm with dynamic thresholds on the performance of PFDCT, and the results of the experiments show that the addition of the marking algorithm will further improve the performance of PFDCT in terms of packet loss rate, latency, and FCT.
Mismatch-Shaping Switching Scheme for Split-Array Capacitive DACs
Authors: Nam Jae-Hyeon , Park Sung-Hyun , Jang Jin-Yeop , Park Sang-Gyu
Published: April 2023

Capacitive DACs (C-DACs) are widely used as stand-alone DACs or in an ADC as auxiliary DACs. An important performance metric of a C-DAC is its energy consumption and the linearity between the digital input and the analog output. In multi-bit C-DACs, the mismatch between the capacitors can degrade linearity, which can be important in high-resolution applications. In this work, we analyze the power consumption and linearity performance of a class of C-DACs called split-array C-DACs. We show that the simple element rotation technique, which is widely used to suppress the mismatch error of DACs, cannot be used with the power-efficient three-level switching scheme to effectively suppress the mismatch error. Then, we propose a switching scheme which can be used with the power efficient three-level switching and can suppress the in-band mismatch error effectively.
Research on the Identification of Particleboard Surface Defects Based on Improved Capsule Network Model
Authors: Wang Chengcheng , Liu Yaqiu , Wang Peiyu , Lv Yunlei
Published: April 2023

Aiming at the problems of low classification accuracy and overfitting caused by the limited number of particleboard image samples, a Capsule Network algorithm based on the improved CBAM (Convolutional Block Attention Module) attention model is proposed. The improved algorithm utilizes the GELU equation to improve the CBAM attention model and incorporates it into the convolutional layer of the Capsule Network. In this way, the improved algorithm optimizes the feature maps of surface defects and, meanwhile, improves the training efficiency and stability of the model. The improved algorithm alleviates the overfitting problem by adding a dropout layer, which makes the model more suitable for small sample classification. The effectiveness of the method proposed in this paper is verified by classification experiments on the dataset of particleboard surface defect images.
Screening and Identification of the Strain Pediococcus acidilactici and Its Application in Fermentation of Corn–Soybean Meal Uncooked Materials
Authors: Xu Su , Song Xinyu , Liu Jirong , Zhang Wenjuan , Yu Xiaochen , Yu Dianyu , Cheng Jianjun
Published: April 2023

Cost and contamination are the bottleneck problems for the replacement of antibiotics with fermented feed. A strain of lactic acid bacteria was isolated and screened from acidified apple juice and identified as Pediococcus acidilactici using morphological, physiological, and biochemical tests and 16S rDNA sequence analysis. The strain was combined with Bacillus subtilis and Saccharomyces cerevisiae to ferment raw corn–soybean meal, and the two-stage fermentation process was optimized with a single-factor test, orthogonal test, and response surface methodology. Compared with unfermented raw material, the protein content of fermented feed was increased by 5.21 percentage points (p < 0.05) and the total amino acids were increased by 3.7 percentage points (p < 0.05), making it rich in amino acids essential for pigs. The high-throughput sequencing results showed that, at the species level, the highest relative abundances of bacteria in the fermentation system were those of Pediococcus acidilactici and Bacillus subtilis, and the most abundant fungi was Saccharomyces cerevisiae. No pathogenic bacteria, such as Salmonella, were detected in the fermentation system. This paper provides a feasible scheme for cheap preparation of an alternative to antibiotics, fermented feed, with uncooked raw materials. It has positive significance for promoting high-value utilization of agricultural and sideline products and improving feed cost-effectiveness.
Microbial and Commercial Enzymes Applied in the Beverage Production Process
Authors: Cosme Fernanda , Inês António , Vilela Alice
Published: April 2023

Enzymes are highly effective biocatalysts used in various industrial processes, playing a key role in winemaking and in other fermented beverages. Many of the enzymes used in fermentation processes have their origin in fruits, in the indigenous microbiota of the fruit, and in the microorganisms present during beverage processing. Besides naturally occurring enzymes, commercial preparations that usually blend different activities are used (glucosidases, glucanases, pectinases, and proteases, among others). Over the years, remarkable progress has been made in enhancing enzyme performance under operating conditions. The winemaking industry has observed a significant improvement in production levels, stimulating the introduction of technological innovations that aim to enhance efficiency and wine quality. Enzymes have traditionally been used in the beverage industry; however, others have been introduced more recently, with numerous studies aimed at optimizing their performance under processing conditions, including the use of immobilized enzymes. Therefore, one major goal of the current review is to give a detailed overview of the endogenous enzyme potential of wine microorganisms, as well as of enzymes obtained from grapes or even commercial preparations, studied and already in use in the beverage industry, and to present the future trends in enzyme production and application.
Flexible Polymer-Ionic Liquid Films for Supercapacitor Applications
Authors: Novakov Christo , Kalinova Radostina , Veleva Svetlana , Ublekov Filip , Dimitrov Ivaylo , Stoyanova Antonia
Published: April 2023

Mechanically and thermally stable novel gel polymer electrolytes (GPEs) have been prepared and applied in supercapacitor cells. Quasi-solid and flexible films were prepared by solution casting technique and formulated by immobilization of ionic liquids (ILs) differing in their aggregate state. A crosslinking agent and a radical initiator were added to further stabilize them. The physicochemical characteristics of the obtained crosslinked films show that the realized cross-linked structure contributes to their improved mechanical and thermal stability, as well as an order of magnitude higher conductivity than that of the non-crosslinked ones. The obtained GPEs were electrochemically tested as separator in symmetric and hybrid supercapacitor cells and showed good and stable performance in the investigated systems. The crosslinked film is suitable for use as both separator and electrolyte and is promising for the development of high-temperature solid-state supercapacitors with improved capacitance characteristics.
Patient-Specific 3D Printed Soft Models for Liver Surgical Planning and Hands-On Training
Authors: Valls-Esteve Arnau , Tejo-Otero Aitor , Lustig-Gainza Pamela , Buj-Corral Irene , Fenollosa-Artés Felip , Rubio-Palau Josep , Barber-Martinez de la Torre Ignasi , Munuera Josep , Fondevila Constantino , Krauel Lucas
Published: April 2023

Background: Pre-surgical simulation-based training with three-dimensional (3D) models has been intensively developed in complex surgeries in recent years. This is also the case in liver surgery, although with fewer reported examples. The simulation-based training with 3D models represents an alternative to current surgical simulation methods based on animal or ex vivo models or virtual reality (VR), showing reported advantages, which makes the development of realistic 3D-printed models an option. This work presents an innovative, low-cost approach for producing patient-specific 3D anatomical models for hands-on simulation and training. Methods: The article reports three paediatric cases presenting complex liver tumours that were transferred to a major paediatric referral centre for treatment: hepatoblastoma, hepatic hamartoma and biliary tract rhabdomyosarcoma. The complete process of the additively manufactured liver tumour simulators is described, and the different steps for the correct development of each case are explained: (1) medical image acquisition; (2) segmentation; (3) 3D printing; (4) quality control/validation; and (5) cost. A digital workflow for liver cancer surgical planning is proposed. Results: Three hepatic surgeries were planned, with 3D simulators built using 3D printing and silicone moulding techniques. The 3D physical models showed highly accurate replications of the actual condition. Additionally, they proved to be more cost-effective in comparison with other models. Conclusions: It is demonstrated that it is possible to manufacture accurate and cost-effective 3D-printed soft surgical planning simulators for treating liver cancer. The 3D models allowed for proper pre-surgical planning and simulation training in the three cases reported, making it a valuable aid for surgeons.
Bigels as Fat Replacers in Fermented Sausages: Physicochemical, Microbiological, Sensory, and Nutritional Characteristics
Authors: Siachou Christina , Zampouni Konstantina , Katsanidis Eugenios
Published: April 2023

Olive oil bigels structured with monoglycerides, gelatin, and κ-carrageenan were designed for the partial substitution of pork backfat in fermented sausages. Two different bigels were used: bigel B60 consisted of 60% aqueous and 40% lipid phase; and bigel B80 was formulated with 80% aqueous and 20% lipid phase. Three different pork sausage treatments were manufactured: control with 18% pork backfat; treatment SB60 with 9% pork backfat and 9% bigel B60; and treatment SB80 with 9% pork backfat and 9% bigel B80. Microbiological and physicochemical analyses were carried out for all three treatments on 0, 1, 3, 6, and 16 days after sausage preparation. Bigel substitution did not affect water activity or the populations of lactic acid bacteria, total viable counts, Micrococcaceae, and Staphylococcacea during the fermentation and ripening period. Treatments SB60 and SB80 presented higher weight loss during fermentation and higher TBARS values only on day 16 of storage. Consumer sensory evaluation did not identify significant differences among the sausage treatments in color, texture, juiciness, flavor, taste, and overall acceptability. The results show that bigels can be utilized for the formulation of healthier meat products with acceptable microbiological, physicochemical, and organoleptic characteristics.
Application of Machine Learning Algorithms to Predict Uncontrolled Diabetes Using the All of Us Research Program Data
Authors: Abegaz Tadesse M. , Ahmed Muktar , Sherbeny Fatimah , Diaby Vakaramoko , Chi Hongmei , Ali Askal Ayalew
Published: April 2023

There is a paucity of predictive models for uncontrolled diabetes mellitus. The present study applied different machine learning algorithms on multiple patient characteristics to predict uncontrolled diabetes. Patients with diabetes above the age of 18 from the All of Us Research Program were included. Random forest, extreme gradient boost, logistic regression, and weighted ensemble model algorithms were employed. Patients who had a record of uncontrolled diabetes based on the international classification of diseases code were identified as cases. A set of features including basic demographic, biomarkers and hematological indices were included in the model. The random forest model demonstrated high performance in predicting uncontrolled diabetes, yielding an accuracy of 0.80 (95% CI: 0.79–0.81) as compared to the extreme gradient boost 0.74 (95% CI: 0.73–0.75), the logistic regression 0.64 (95% CI: 0.63–0.65) and the weighted ensemble model 0.77 (95% CI: 0.76–0.79). The maximum area under the receiver characteristics curve value was 0.77 (random forest model), while the minimum value was 0.7 (logistic regression model). Potassium levels, body weight, aspartate aminotransferase, height, and heart rate were important predictors of uncontrolled diabetes. The random forest model demonstrated a high performance in predicting uncontrolled diabetes. Serum electrolytes and physical measurements were important features in predicting uncontrolled diabetes. Machine learning techniques may be used to predict uncontrolled diabetes by incorporating these clinical characteristics.
Assessment of Psychometric Properties of the Malay Version of the Brief Resilience Scale (BRS-M) among Non-Academic Staff Working from Home during COVID-19 in Malaysia
Authors: Ahmad Sabki Zuraida , Kim Lee Hui , Danaee Mahmoud , Sulaiman Ahmad Hatim , Razali Khairul Arif , Koh Ong Hui , Kanagasundram Sharmilla , Kaur Manveen , Azhar Fatin Liyana , Francis Benedict
Published: April 2023

This study aims to validate the Malay version of the Brief Resilience Scale (BRS-M) in order for the scale to be available among the Malay-speaking population. Two hundred and ninety-eight non-academic staff completed the Malay version of the Brief Resilience Scale (BRS-M), Malay Copenhagen Burnout Inventory (CBI-M), and Malay Depression, Anxiety, and Stress Scale (M-DASS-21). To explore the factor structure of BRS-M, exploratory factor analysis (EFA) with the first group of 149 participants was conducted using FACTOR (v.11) software. Confirmatory factor analysis (CFA) was conducted from the data of the second group of 149 participants using SEM_PLS software. The EFA revealed a two-factor model; Factor 1 =”Resilience” and Factor 2 = ”Succumbing”. The CFA indicated a sufficient internal consistency reliability (Cronbach’s α = 0.806 and McDonald’s omega, ω = 0.812) and a good fit with SRMR = 0.031. BRS-M, CBI-M, and M-DASS-21 displayed a satisfactory concurrent validity result. Household income and marital status had significant association with resilience level, with low household income (B40 group) being a predictor of lower resilience. The BRS-M demonstrated favourable psychometric properties in terms of reliability and validity to assess the level of resilience among non-academic staff in Malaysia.
Relationship between Coma Recovery Scale-Revised and the Thalamocortical Tract of Ascending Reticular Activating System in Hypoxic–Ischemic Brain Injury: A Pilot Study
Authors: Jang Sungho , Choi Eunbi
Published: April 2023

Background: This pilot study examined the relationship between the Coma Recovery Scale-Revised (CRS-R) and the five subparts of the thalamocortical tract in chronic patients with hypoxic–ischemic brain injury by diffusion tensor tractography (DTT). Methods: Seventeen consecutive chronic patients with hypoxic–ischemic brain injury were recruited. The consciousness state was evaluated using CRS-R. The five subparts of the thalamocortical tract (the prefrontal cortex, the premotor cortex, the primary motor cortex, the primary somatosensory cortex, and the posterior parietal cortex) were reconstructed using DTT. Fractional anisotropy and the tract volume of each subpart of the thalamocortical tract were estimated. Results: The CRS-R score showed a moderate positive correlation with the tract volume of the prefrontal cortex part of the thalamocortical tract (p < 0.05). In addition, the tract volume of the prefrontal cortex component of the thalamocortical tract could explain the variability in the CRS-R score (p < 0.05). Conclusion: The prefrontal cortex part was closely related to the CRS-R score in chronic patients with hypoxic–ischemic brain injury. In addition, the change in the remaining number of neural fibers of the prefrontal cortex part appeared to be related to the change in conscious state.
Predicting Disability Using a Nomogram of the Tilburg Frailty Indicator (TFI)
Authors: Gobbens Robbert J. , Santiago Livia M. , Uchmanowicz Izabella , van der Ploeg Tjeerd
Published: April 2023

Disability is associated with lower quality of life and premature death in older people. Therefore, prevention and intervention targeting older people living with a disability is important. Frailty can be considered a major predictor of disability. In this study, we aimed to develop nomograms with items of the Tilburg Frailty Indicator (TFI) as predictors by using cross-sectional and longitudinal data (follow-up of five and nine years), focusing on the prediction of total disability, disability in activities of daily living (ADL), and disability in instrumental activities of daily living (IADL). At baseline, 479 Dutch community-dwelling people aged ≥75 years participated. They completed a questionnaire that included the TFI and the Groningen Activity Restriction Scale to assess the three disability variables. We showed that the TFI items scored different points, especially over time. Therefore, not every item was equally important in predicting disability. ‘Difficulty in walking’ and ‘unexplained weight loss’ appeared to be important predictors of disability. Healthcare professionals need to focus on these two items to prevent disability. We also conclude that the points given to frailty items differed between total, ADL, and IADL disability and also differed regarding years of follow-up. Creating one monogram that does justice to this seems impossible.
Treatment Advances in Sepsis and Septic Shock: Modulating Pro- and Anti-Inflammatory Mechanisms
Authors: Marques Adriana , Torre Carla , Pinto Rui , Sepodes Bruno , Rocha João
Published: April 2023

Sepsis is currently defined as a life-threatening organ dysfunction caused by a dysregulated host response to infection, and it affects over 25 million people every year. Even more severe, septic shock is a subset of sepsis defined by persistent hypotension, and hospital mortality rates are higher than 40%. Although early sepsis mortality has greatly improved in the past few years, sepsis patients who survive the hyperinflammation and subsequent organ damage often die from long-term complications, such as secondary infection, and despite decades of clinical trials targeting this stage of the disease, currently, no sepsis-specific therapies exist. As new pathophysiological mechanisms have been uncovered, immunostimulatory therapy has emerged as a promising path forward. Highly investigated treatment strategies include cytokines and growth factors, immune checkpoint inhibitors, and even cellular therapies. There is much to be learned from related illnesses, and immunotherapy trials in oncology, as well as the recent COVID-19 pandemic, have greatly informed sepsis research. Although the journey ahead is a long one, the stratification of patients according to their immune status and the employment of combination therapies represent a hopeful way forward.
Long-Term Results of Femorodistal Sequential Composite-Bypass Combining Heparin-Bonded PTFE-Prosthesis and Autologous Vein Using the Deutsch Bridge Technique in Critical Limb-Threatening Ischemia
Authors: Neufang Achim , Zhghenti Valerian , Vargas-Gomez Carolina , Umscheid Thomas , von Flotow Peter , Schmiedel Rainer , Savvidis Savvas
Published: April 2023

Background: Autologous vein bypass provides excellent long-term results in critical limb-threatening ischemia (CLTI), but a substantial portion of patients have insufficient vein length. In limbs with two distal outflow vessels and limited vein length, a vascular prosthesis may be combined with autologous vein for a sequential composite bridge bypass (SCBB). Results regarding graft function, limb salvage and reinterventions are presented. Methods: Between January 2010 and December 2019, 47 consecutive SCBB operations with a heparin-bonded PTFE-prosthesis and autologous vein were performed. Grafts were followed with a duplex scan with prospective documentation in a computerized vascular database. Retrospective analysis of graft patency, limb salvage and patient survival was performed. Results: Mean follow-up was 34 months (range 1–127 months). 30-day mortality was 10.6% and 5-year patient survival 32%. Postoperative bypass occlusion occurred in 6.4% and late occlusions or graft stenoses in 30%. Two prostheses developed late infection and seven legs were amputated. Primary, primary assisted, secondary patency and limb salvage rate were 54%, 63%, 66% and 85% after 5 years, respectively. Conclusions: SCBB patency and limb salvage were good despite a high early postoperative mortality. Combination of a heparin-bonded PTFE-prosthesis and autologous vein appears to be a valuable tool in CLTI in case of insufficient vein.
Primary Non-Aortic Lesions Are Not Rare in Marfan Syndrome and Are Associated with Aortic Dissection Independently of Age
Authors: Sénémaud Jean , Gaudry Marine , Jouve Elisabeth , Blanchard Arnaud , Milleron Olivier , Dulac Yves , Olivier-Faivre Laurence , Stephan Dominique , Odent Sylvie , Lanéelle Damien , Dupuis-Girod Sophie , Jondeau Guillaume , Bal-Theoleyre Laurence
Published: April 2023

Purpose: The study sought to estimate the prevalence of primary non-aortic lesions (PNAL) unrelated to extension of aortic dissection (AD) in a cohort of patients with Marfan syndrome (MFS). Methods: Adult patients presenting with pathogenic FBN1 mutations and an available pan-aortic contrast-enhanced CTA in eight French MFS clinics from April to October 2018 were included. Clinical and radiological data, particularly the presence of aortic lesions and PNAL (including aneurysm and ectasia), were retrospectively analyzed. Results: Out of 138 patients, 28 (20.3%) had PNAL. In total, 27 aneurysms in 13 patients and 41 ectasias in 19 patients were reported mainly in the subclavian, iliac, and vertebral segments. Four patients (31%) with aneurysms and none with ectasia required prophylactic intervention during follow-up (median: 46 months). In multivariate analysis, factors associated with PNAL were history of AD (OR = 3.9, 95%CI: 1.3–12.1, p = 0.018), history of previous descending aortic surgery (OR = 10.3, 95%CI: 2.2–48.3, p = 0.003) and age (per 10 years OR = 1.6, 95%CI: 1.1–2.4, p = 0.008). Conclusion: PNAL is not rare in MFS patients with evolutive aortic disease. Natural history may differ between aneurysms and ectasia, emphasizing the need for standardized definitions and systematic screening for PNAL.
Experimental Investigation of Wave Propagation and Overtopping over Seawalls on a Reef Flat
Authors: Gao Yangyang , Ren Linguang , Wang Lizhong
Published: April 2023

A series of physical model tests were performed to investigate the wave propagation, pressure, and wave overtopping processes for vertical and sloped seawalls on the reef flat. For both regular and irregular waves, the effects of incident wave height, wave period, relative distance, fore reef slope, and still-water depth on wave propagation, wave pressure distribution, and mean wave overtopping discharge were investigated. The peak pressure increased with the increase in incident wave height and decreased with the increase in relative distance and fore reef slope. The mean wave overtopping discharge over the vertical and sloped seawalls increased with the increase in incident wave height, wave period, and still-water depth, but it was significantly reduced with the increase in relative distance and fore reef slope. Modified empirical formulas are proposed for predicting the wave force and mean wave overtopping discharge over the vertical and sloped seawalls on the reef flat for both regular and irregular waves.
Integrated Ecosystem Assessments for Fisheries Management in the Yellow Sea, the East China Sea, and the East/Japan Sea
Authors: Lee Sang Heon , Youn Seok-Hyun
Published: April 2023

Marine environmental conditions are highly distinct in the Yellow Sea, the East China Sea, and the East/Japan Sea, with characteristics such as the shallow and turbid conditions of the Yellow Sea, relatively warm subtropical conditions of the East China Sea, and deep and semi-enclosed nature of the East/Japan Sea [...]
Loss of Phosphomannose Isomerase Impairs Growth, Perturbs Cell Wall Integrity, and Reduces Virulence of Fusarium oxysporum f. sp. cubense on Banana Plants
Authors: Usman Sayed , Ge Xinwei , Xu Yueqiang , Qin Qijian , Xie Jin , Wang Bin , Jin Cheng , Fang Wenxia
Published: April 2023

Fusarium oxysporum f. sp. cubense tropical race 4 (Foc TR4) causes Fusarium wilt of banana, necessitating urgent measures to control this disease. However, the molecular mechanisms underlying Foc TR4 virulence remain elusive. Phosphomannose isomerase is a key enzyme involved in the biosynthesis of GDP mannose, an important precursor of fungal cell walls. In this study, two phosphomannose isomerases were identified in the Foc TR4 genome, of which only Focpmi1 was highly expressed throughout all developmental stages. Generated null mutants in Foc TR4 showed that only the ΔFocpmi1 mutant required exogenous mannose for growth, indicating that Focpmi1 is the key enzyme involved in GDP mannose biosynthesis. The Focpmi1 deficient strain was unable to grow without exogenous mannose and exhibited impaired growth under stress conditions. The mutant had reduced chitin content in its cell wall, rendering it vulnerable to cell wall stresses. Transcriptomic analysis revealed up- and down-regulation of several genes involved in host cell wall degradation and physiological processes due to the loss of Focpmi1. Furthermore, Focpmi1 was also found to be crucial for Foc TR4 infection and virulence, making it a potential antifungal target to address the threats posed by Foc TR4.
Genomic and Transcriptomic Approaches Provide a Predictive Framework for Sesquiterpenes Biosynthesis in Desarmillaria tabescens CPCC 401429
Authors: Zhang Tao , Feng Jianjv , He Wenni , Rong Xiaoting , Lv Hui , Li Jun , Li Xinxin , Wang Hao , Wang Lu , Zhang Lixin , Yu Liyan
Published: April 2023

Terpenoids constitute a structurally diverse class of secondary metabolites with wide applications in the pharmaceutical, fragrance and flavor industries. Desarmillaria tabescens CPCC 401429 is a basidiomycetous mushroom that could produce anti-tumor melleolides. To date, no studies have been conducted to thoroughly investigate the sesquiterpenes biosynthetic potential in Desarmillaria or related genus. This study aims to unravel the phylogeny, terpenome, and functional characterization of unique sesquiterpene biosynthetic genes of the strain CPCC 401429. Herein, we report the genome of the fungus containing 15,145 protein-encoding genes. MLST-based phylogeny and comparative genomic analyses shed light on the precise reclassification of D. tabescens suggesting that it belongs to the genus Desarmillaria. Gene ontology enrichment and pathway analyses uncover the hidden capacity for producing polyketides and terpenoids. Genome mining directed predictive framework reveals a diverse network of sesquiterpene synthases (STSs). Among twelve putative STSs encoded in the genome, six ones are belonging to the novel minor group: diverse Clade IV. In addition, RNA-sequencing based transcriptomic profiling revealed differentially expressed genes (DEGs) of the fungus CPCC 401429 in three different fermentation conditions, that of which enable us to identify noteworthy genes exemplified as STSs coding genes. Among the ten sesquiterpene biosynthetic DEGs, two genes including DtSTS9 and DtSTS10 were selected for functional characterization. Yeast cells expressing DtSTS9 and DtSTS10 could produce diverse sesquiterpene compounds, reinforced that STSs in the group Clade IV might be highly promiscuous producers. This highlights the potential of Desarmillaria in generating novel terpenoids. To summarize, our analyses will facilitate our understanding of phylogeny, STSs diversity and functional significance of Desarmillaria species. These results will encourage the scientific community for further research on uncharacterized STSs of Basidiomycota phylum, biological functions, and potential application of this vast source of secondary metabolites.
Supply Chain Risk Management in a Digital Era: Evidence from SMEs of Clothing Retailers in Australia
Authors: Mamun Mehadi
Published: April 2023

With the increased globalisation and disruptions faced by businesses in this digital era and the occurrence of natural disasters such as floods and disease outbreaks in the world, supply chain risks and management of those risks are major challenges for businesses, especially for SMEs of clothing retailers in Australia. This study, hence, is carried out using an exploratory case study research method, and the data have been collected through semi-structured face-to-face interviews with key informants from managerial levels of 20 Australian SMEs of clothing retailing businesses to identify various supply chain risks and their management processes. This study finds five supply chain risks, namely supply risk, demand risk, financial risk, environmental risk, and operational risk, that the SMEs of clothing retailers mostly face in the supply chain. This study also finds that most of the investigated retailers lack a formal risk identification approach, though they informally use the reactive and proactive methods of risk identification. Furthermore, the assessment methods are not well established in most of the participating firms, and supplier monitoring receives more attention compared to their own performance to deal with their supply chain risks. This study contributes to the body of knowledge by being one of the first empirical studies to explore the SMEs of clothing retailers’ supply chain risks and their management processes in the Australian business context, which can add value in guiding supply chain design decisions for SMEs in other sectors.
Diode Laser Therapy for Radiation-Induced Vascular Ectasia: Long-Term Results and Cost Analysis
Authors: Polese Lino , Giugliano Emilia , Cadrobbi Roberto , Boemo Deris Gianni
Published: April 2023

Background: Collateral damage to surrounding healthy tissues has been reported in patients who undergo radiation therapy for pelvic malignancies. This study aimed to evaluate the safety, efficacy and cost efficiency of endoscopic diode laser therapy in patients diagnosed with chronic radiation proctitis (CRP). Methods: The data of 24 patients (median age 78, range 67–90 years) who presented rectal bleeding and were diagnosed with CRP after undergoing high-dose radiotherapy for prostatic cancer and underwent diode laser therapy were evaluated retrospectively. Non-contact fibers were used in the patients who underwent the procedure without sedation in an outpatient setting. Results: The patients underwent a median of two sessions; overall, a mean of 1591 J of laser energy per session was used. No complications were noted during or after the procedures. Bleeding was completely resolved in 21/24 (88%) patients, and two patients showed improvement (96%). It was not necessary to suspend antiplatelet (six patients) or anticoagulant (four patients) therapy during the treatment course. The mean cost per session was EUR 473.4. Conclusions: The study findings demonstrated that endoscopic non-contact diode laser treatment in CRP patients is safe, effective and cost efficient. For this procedure, antiplatelet and anticoagulant therapy suspension, intraprocedural sedation and hospital admission are not required.