bluuebunny/crossref_metadata_2025 huggingface dataset:
A Handheld Metabolic Device (Lumen) to Measure Fuel Utilization in Healthy Young Adults: Device Validation Study (Preprint)
Authors: Lorenz Kent Arnold , Yeshurun Shlomo , Aziz Richard , Ortiz-Delatorre Julissa , Bagley James Robert , Mor Merav , Kern Marialice
Published: May 2021

BACKGROUND

Metabolic carts measure the carbon dioxide (CO2) produced and oxygen consumed by an individual when breathing to assess metabolic fuel usage (carbohydrates versus fats). However, these systems are expensive, time-consuming, and only available in health care laboratory settings. A small handheld device capable of determining metabolic fuel usage via CO2 from exhaled air has been developed.

OBJECTIVE

The aim of this study is to evaluate the validity of a novel handheld device (Lumen) for measuring metabolic fuel utilization in healthy young adults.

METHODS

Metabolic fuel usage was assessed in healthy participants (n=33; mean age 23.1 years, SD 3.9 years) via respiratory exchange ratio (RER) values obtained from a metabolic cart as well as % CO2 from the Lumen device. Measurements were performed at rest in two conditions: fasting, and after consuming 150 grams of glucose, in order to determine changes in metabolic fuel usage. Reduced major axis regression and simple linear regression were performed to test for agreement between RER and Lumen % CO2.

RESULTS

Both RER and Lumen % CO2 significantly increased after glucose intake (P<.001 for both) compared with fasting conditions, by 0.089 and 0.28, respectively. Regression analyses revealed an agreement between the two measurements (F1,63=18.54; P<.001).

CONCLUSIONS

This study shows the validity of Lumen for detecting changes in metabolic fuel utilization in a comparable manner with a laboratory standard metabolic cart, providing the ability for real-time metabolic information for users under any circumstances.
The Communicating Narrative Concerns Entered by Registered Nurses (CONCERN) Clinical Decision Support Early Warning System: Protocol for a Cluster Randomized Pragmatic Clinical Trial (Preprint)
Authors: Rossetti Sarah Collins , Dykes Patricia C , Knaplund Christopher , Kang Min-Jeoung , Schnock Kumiko , Garcia Jr Jose Pedro , Fu Li-Heng , Chang Frank , Thai Tien , Fred Matthew , Korach Tom Z , Zhou Li , Klann Jeffrey G , Albers David , Schwartz Jessica , Lowenthal Graham , Jia Haomiao , Liu Fang , Cato Kenrick
Published: May 2021

BACKGROUND

Every year, hundreds of thousands of inpatients die from cardiac arrest and sepsis, which could be avoided if those patients’ risk for deterioration were detected and timely interventions were initiated. Thus, a system is needed to convert real-time, raw patient data into consumable information that clinicians can utilize to identify patients at risk of deterioration and thus prevent mortality and improve patient health outcomes. The overarching goal of the COmmunicating Narrative Concerns Entered by Registered Nurses (CONCERN) study is to implement and evaluate an early warning score system that provides clinical decision support (CDS) in electronic health record systems. With a combination of machine learning and natural language processing, the CONCERN CDS utilizes nursing documentation patterns as indicators of nurses’ increased surveillance to predict when patients are at the risk of clinical deterioration.

OBJECTIVE

The objective of this cluster randomized pragmatic clinical trial is to evaluate the effectiveness and usability of the CONCERN CDS system at 2 different study sites. The specific aim is to decrease hospitalized patients’ negative health outcomes (in-hospital mortality, length of stay, cardiac arrest, unanticipated intensive care unit transfers, and 30-day hospital readmission rates).

METHODS

A multiple time-series intervention consisting of 3 phases will be performed through a 1-year period during the cluster randomized pragmatic clinical trial. Phase 1 evaluates the adoption of our algorithm through pilot and trial testing, phase 2 activates optimized versions of the CONCERN CDS based on experience from phase 1, and phase 3 will be a silent release mode where no CDS is viewable to the end user. The intervention deals with a series of processes from system release to evaluation. The system release includes CONCERN CDS implementation and user training. Then, a mixed methods approach will be used with end users to assess the system and clinician perspectives.

RESULTS

Data collection and analysis are expected to conclude by August 2022. Based on our previous work on CONCERN, we expect the system to have a positive impact on the mortality rate and length of stay.

CONCLUSIONS

The CONCERN CDS will increase team-based situational awareness and shared understanding of patients predicted to be at risk for clinical deterioration in need of intervention to prevent mortality and associated harm.

CLINICALTRIAL

ClinicalTrials.gov NCT03911687; https://clinicaltrials.gov/ct2/show/NCT03911687

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/30238
Simulation-Based Teaching of Telemedicine for Future Users of Teleconsultation and Tele-Expertise: Feasibility Study (Preprint)
Authors: Bouamra Benjamin , Chakroun Karim , Medeiros De Bustos Elisabeth , Dobson Jennifer , Rouge Jeanne-Antide , Moulin Thierry
Published: May 2021

BACKGROUND

Health care professionals worldwide are increasingly using telemedicine in their daily clinical practice. However, there is still a lack of dedicated education and training even though it is needed to improve the quality of the diverse range of telemedicine activities. Simulation-based training may be a useful tool in telemedicine education and training delivery.

OBJECTIVE

This study aims to assess the feasibility and acceptability of simulation-based telemedicine training.

METHODS

We assessed five telemedicine training sessions conducted in a simulation laboratory. The training was focused on video teleconsultations between a patient and a health care professional. The assessment included the participants’ satisfaction and attitudes toward the training.

RESULTS

We included 29 participants in total. Participant satisfaction was high (mean score 4.9 of 5), and those that took part stated the high applicability of the simulation-based training to their telemedicine practices (mean score 4.6 of 5). They also stated that they intended to use telemedicine in the future (mean score 4.5 of 5).

CONCLUSIONS

Simulation-based training of telemedicine dedicated to video teleconsultation was feasible and showed high satisfaction from participants. However, it remains difficult to scale for a high number of health care professionals.
The impact of urban light rail transit on double-story terraced property values in the Greater Kuala Lumpur, Malaysia
Authors: Dziauddin Mohd Faris
Published: May 2021

Introducing a rail transit system into an urban region is expected to increase land values, and subsequently, residential property values. Despite this general belief, there has been limited research on the impact of proximity to urban light rail transit stations in developing countries setting. This study, therefore, investigates the impact of proximity to urban light rail transit on double-story terraced property values in the Greater Kuala Lumpur, Malaysia, using hedonic pricing model. The findings suggest urban light rail transit has a positive and significant impact on surrounding double-story terraced residential property values – estimated at a premium of 12.3% and 9.8% for properties located up to 1000 m and 1001 – 2000 m to the nearest light rail transit station respectively. The findings of the study are useful for investors and developers, namely to build more houses near urban rail transit infrastructure since they lead to significant appreciation in value.
Tourist Attraction and Tourist Motivation in The Patuha Mountain Area, West Java
Authors: Putri Dema Amalia , Susilowati Maria Hedwig Dewi , Semedi Jarot Mulyo
Published: May 2021

The Bandung Regency Spatial Plan for 2007-2027 regulates The Patuha Mountain Area as one of the regions that have a special role in the tourism sector. This research was conducted to find out the attractiveness value and motivation of tourists on tourist attractions as well as the relationship between them in The Patuha Mountain Area. Assessment of tourist attractiveness value was based on the completeness of attraction, tourist facilities, and accessibility. Meanwhile, tourist motivation was based on tourist preferences, tourist needs, and tourist travel status. The variables were analyzed using spatial analysis and chi-square test statistics. The results indicated that the high attractiveness value has a nodal destination system, while medium and low attractiveness value has a linear destination system. Tourist motivation was being dominated by flashpacker types. Tourists who visited The Patuha Mountain Area are not being influenced by the attractiveness value of tourist attractions. Although tourist attraction has complete tourist facilities, tourists only focus on the attraction compared to the tourist facilities and accessibility.
How Long Can We Build It? Ensuring Usability of a Scientific Code Base
Authors: Rechert Klaus , Oberhauser Jurek , Gieschke Rafael
Published: May 2021

Software and in particular source code became an important component of scientific publications and henceforth is now subject of research data management.  Maintaining source code such that it remains a usable and a valuable scientific contribution is and remains a huge task. Not all code contributions can be actively maintained forever. Eventually, there will be a significant backlog of legacy source-code. In this article we analyse the requirements for applying the concept of long-term reusability to source code. We use simple case study to identify gaps and provide a technical infrastructure based on emulator to support automated builds of historic software in form of source code.
Interstate green standards of formation sustainable built environment vital activity
Authors: Telichenko Valeriy I. , Benuzh Andrey A. , Suhinina Elena A.
Published: May 2021

Introduction. Due to the negative environmental situation on Earth, the necessity to use “green” standards in construction, regulated by environmental standards, to reduce the negative impact on nature and create favorable living environment for humans was determined. It was revealed that eleven of the seventeen Sustainable Development Goals approved at the United Nations General Assembly are interrelated with construction. At the same time, “green” design standards are a mechanism for achieving Sustainable Development Goals as well as regulatory tool for creating an environmentally friendly environment for living and working.

Materials and methods. The stages of the formation of environmental legislation in construction are studied. Specific features of the formation of regulatory documents in the field of environmental protection and environmental design (mid 20th – early 21st centuries), as well as the transition to the creation of National Russian “green” standards are reviewed. The mechanism of development of interstate standards on the basis of the Technical Committee is being studied.

Results. National environmental legislation and Russian national “green” standards regulatory requirements are studied. The advantages and disadvantages of current environmental certification systems and core aspects of buildings environmental assessment are highlighted. The necessity for the use of interstate environmental standards in design and construction is determined along with the allocation of strategy for further development in the urban planning field. Specific features of the formation of “green” construction in Russia, as a driver for the Eurasian Customs Union are revealed.

Conclusions. The priority of formating “green” living environment on the basis of the introduction of new regulatory framework on environmentally sustainable design to promote the National “green” standard in construction at the interstate level is outlined.
Filing of DMF in the US, EU, and India, and its comparative review
Authors: Sravanti Veera Kota Lakshmi , Bandla Ruchitha , Reddy Juturi Ravi Kumar
Published: May 2021

A Drug Master File (DMF) covers all comprehensive, accurate, and precise information about Active Pharmaceutical Ingredient (API) or Finished Product Dosage Form (FP). It is a confidential document that contains complete, factual, and correct information about the active pharmaceutical ingredient and drug product's chemistry, manufacture, stability, purity, impurity profile, packaging, and the cGMP (Current Good Manufacturing Practices) status of any human drug product. When a DMF is filed, it allows a company to safeguard its intellectual property from its partner while complying with regulatory requirements when its process details are disclosed. There is no legalised or regulatory requirement to file a DMF. A DMF comprises of two parts: (a) the Applicant's Part (Open Part), which contains all the information to assess the quality that the license-holder requires and submit a license or amendment application; and (b) the Restricted Part (Closed Part), which contains confidential information about the manufacturing procedure which is only disclosed to the authorities.

A DMF can be used by a holder who establishes the file or by one or more parties to support their files or applications.

The present study is to brief an overview of DMF filing in different countries, which are the USA, Europe, and India. It also gives information on regulatory requirements of Drug Master Files by Food and Drug Administration (USA), European Medicines Agency (Europe), and Central Drug and Standard Control Organization (India) and their comparison.
Comparative study of updated Clinical Trial Regulations in India with respect to Australia, Europe, Japan and US
Authors: Kumar Devender , Rahi Shivali , Rana Arpana
Published: May 2021

The national regulatory authorities, such as the US Food and Drug Administration (FDA), the European Medicines Agency (EMA), Central Drugs Standard Control Organization and the Australian Therapeutic Goods Administration (TGA), approve every drug that is prescribed for patients around the world. The process of approval undertaken by pharmaceutical companies for drug candidates consists of a series of phases to ensure the product is safe and effective at treating the disease.

In this paper, we will compare the clinical trial regulations of India with respect to Australia, Europe, Japan & USA in order to determine the safety and efficacy of pharmaceutical products like drugs, biologics and medical devices in different geographical regions and to confirm the clinical trials studies follow strict scientific standards.
A Review on Diabetic Peripheral Neuropathy
Authors: Ray Jasaswi , Sahoo Chinmaya Keshari , Mohanty Rajashree , Sahoo Rakesh , Dalai Rajashree
Published: May 2021

Diabetic peripheral neuropathy (DPN) is a common complication of both type 1 and type 2 diabetes affecting over 90% of the diabetic patients. Due to the toxic effects of hyperglycemia there is development of this complication. It is typically characterized by significant deficits in tactile sensitivity, vibration sense, lower-limb proprioception, and kinesthesia. Painful DPN has been shown to be associated with significant reductions in overall quality of life, increased levels of anxiety and depression, sleep impairment, and greater gait variability. Hence DPN is often inadequately treated, and the role of improving glycaemic control in diabetes. Major international clinical guidelines for the management of DPN recommend several symptomatic treatments. First-line therapies include tricyclic antidepressants, serotonin–noradrenaline reuptake inhibitors, and anti-consultants that act on calcium channels. Other therapies include opioids and topical agents such as capsaicin and lidocaine. The objectives of this paper are to review current guidelines for the pharmacological management of DPN.

Keywords: DPN, hyperglycemia, depression, lidocaine
Corona Virus (COVID-19) Symptoms Prevention and Treatment: A Short Review
Authors: Singh Ranjan , Sarsaiya Surendra , Singh Tanim Arpit , Singh Trashi , Pandey Laxmi Kant , Pandey Prabhash Kumar , Khare Neeraj , Sobin Femina , Sikarwar Ranjana , Gupta Mahendra Kumar
Published: May 2021

There is a new world health crisis threatening the public with spread of COVID-19 (Coronavirus Disease-2019). Since 2019 when Covid-19 emerged in Hunan seafood market at Wuhan, South China and rapidly spread throughout the world, the virus outbreak has been declared a public health emergency by the WHO. Corona virus causes respiratory infection including pneumonia, cold, sneezing and coughing while in animal it causes diarrhea and upper respiratory diseases. Corona virus transmitted human to human or human to animal via airborne droplets. Patient shows various symptoms like fever, cough, sore throat, breathlessness and fatigue. The disease is being cured through general treatment, symptomatic treatment and by other methods. This review outlines the Epidemiology, Diagnosis, Management and prevention of this fatal disease.

Keywords: Coronavirus disease-2019, COVID-19, Respiratory Syndrome, Symptoms, Prevention, Treatment.
Comparative study of the anticoagulant powers of the aqueous macerate, ethanolic macerate and aqueous decoction of the leaves of Uvaria chamae P. Beauv. (Annonaceae)
Authors: Bamba Bourahima , Benie Comoé Koffi Donatien , Doukourou Dahiro Noél , Wacoubo Brice Herman , Tape Doris Leslie , Dasse Sery Romuald , Ouattara Karamoko
Published: May 2021

Data on the anticoagulant power of Uvaria chamae, a plant used in traditional medicine, remain unknown despite its many therapeutic and biological virtues. The present study aimed to compare the anticoagulant effects of aqueous macerate, ethanolic macerate and aqueous decoction of U. chamae leaves. The anticoagulant activity of macerated and decocted U. chamae was evaluated in vitro against endogenous and exogenous coagulation pathways in a pool of displaced normal plasmas. These two pathways are explored using two global and chronometric tests including Cephalin-Kaolin Time (TCK) and Prothrombin Time (TQ). The results obtained revealed that the incubation time of U. chamae macerates and decoctions with plasma significantly influences their anticoagulant power. This evaluation showed that these macerated and decocted products exerted anticoagulant power at concentrations dependent on these two coagulation pathways. This anticoagulant power at the level of the aqueous decocted was more significant (P ˂ 0.001) on these two coagulation pathways but it was more marked on the endogenous pathway than on the exogenous pathway. This anticoagulant power at the level of the aqueous decocted was more significant (P ˂ 0.001) on these two coagulation pathways but it was more marked on the endogenous pathway than on the exogenous pathway. This Ivorian plant could thus be considered as a natural source of anticoagulant agents for medicinal purposes.

Keywords: Uvaria chamae, Anticoagulant, Aqueous macerate, Ethanolic macerate, Aqueous decocted
Preliminary Phytochemical Screening and Antimicrobial Activity of the Hydroethanolic Extract of the Fruits of Solanum torvum (Swartz) (Solanaceae) Use as Vegetable in Togo
Authors: MELILA MAMATCHI , ETSE Djidjole Kodjo , SIKA Firmain , AWILI Tètouwalla , KANABIYA Essodjolon , AMEGAH Laurance Adjo , MADJALANI Hèzouwè , NOVIDZRO Mawuéna Kosi , BAKOMA Batomayena
Published: May 2021

The fruits of Solanum torvum (Swartz), a vegetable-fruit, are used in traditional medicine in Togo in the treatment of infectious diseases and as an anti-anemic. This study then focused on the antimicrobial activity assessment of the hydroethanolic extract of these fruits in the interest of contributing to the valorization of this Togolese flora’s species. A hydroethanolic extraction (50 % - 50 %: v/v) was performed followed by preliminary phytochemical tests. Antimicrobial activity was determined on fourteen bacterial strains using the agar diffusion method. Qualitative phytochemical screening revealed the presence of alkaloids, reducing compounds, tannins, cardiac glycosides, flavonoids, coumarins, triterpenes, saponins, total carbohydrates and free quinones. The extract was active on the reference strains of S. aureus, E. coli, S. pneumoniae and P. aeruginosa. However, this activity was only observed on clinical strains of S. pneumoniae and P. aeruginosa. The extract showed MICs of 25 and 50 mg/ml and BMCs of 50 and 100 mg/ml respectively for S. pneumoniae and P. aeruginosa. The MBC/MIC ratio for these two strains was 2. These fruits would then have bacteriostatic activity on S. pneumoniae and P. aeruginosa. The antibacterial properties of the extract on these germs could justify the use of this plant in traditional medicine for the treatment of certain bacterial infections.

Keywords: Solanum torvum, fruits, phytochemical compounds, antimicrobial activity
Mucoadhesive Microspheres: A Targeted Drug Delivery System
Authors: Raj Hans , Sharma Ankita , Sharma Shagun , Verma Kapil Kumar , Chaudhary Amit
Published: May 2021

Carrier technology is a novel and groundbreaking drug delivery system. Microspheres transmit the drug by affixing it to carrier particle-like Microspheres, Nanoparticles and Liposomes due to their smaller size and other useful properties. Mucoadhesive Microspheres are an integral component of this multi-particle drug delivery system and play an important function in the delivery of a novel drug. This drug delivery improves the therapeutic effectiveness of the drug. Mucoadhesive microspheres have a longer duration of residence at the absorption site, which leads to the accuracy of the drug targeting at the absorption site and improves the therapeutic efficacy of the drug. Mucoadhesive microspheres are formed by either systemic or local effects in gastrointestinal, oral, vaginal, nasal, rectal, ocular delivery. This is the ideal targeting device which could be done in a variety of ways.

Keywords: Microspheres, Bioadhesion, Polymer, Bioavailability
A Review of the Pharmacological Characteristics of Vanillic Acid
Authors: Ingole Ashwini , Kadam Megha P , Dalu Aishwarya P. , Kute Shital M , Mange Piyusha R , Theng Vaishali D , Lahane Om R , Nikas Aniket P , Kawal Yash V , Nagrik Shatrughna U. , Patil Prashant A.
Published: May 2021

A dihydroxybenzoic acid analog used as a flavoring agent is vanillic acid (4hydroxy-3-methoxybenzoic acid). It's a form of vanillin that has been oxidized. It's also a step in the process of making vanillin from Ferulic Acid. Vanillic acid has seen a lot of press because of its many uses in the cosmetics, fruit, flavorings, cigarettes,alcohols, drinks, and polymer sectors. It's said to have effective antioxidant, anti-inflammatory, and neuroprotective properties. The pharmacological impact on oxidative stress-induced neuro-degeneration, on the other hand, have not been thoroughly examined. The pharmacological properties of vanillic Acid lead to its possible use in the treatment of various diseases.

Keywords: Vanillic acid, Pharmacological Potential, wound healing, Antioxidants
[DBN][HSO4]-Promoted facile and green synthesis of 2-Amino-4H-pyrans derivatives under microwave irradiation
Authors: Mane Vishal , Mane Dhanjay
Published: May 2021

The [DBN][HSO4] -promoted Knoevenagel condensation followed by cyclization protocol has been developed for the first time by a successive reaction of aldehydes, dimedone and malononitrile to afford 2-Amino-4H-pyrans derivatives in high to excellent yields at room temperature. The synergic couple of microwave and ionic liquid provided the capability to allow a variability of functional groups, short reaction times, easy workup, high yields, recyclability of the catalyst, and solvent-free conditions, thus providing economic and environmental advantages.

Keywords: [DBN][HSO4], Environmentally benign, 2-Amino-4H-pyrans, Knoevenagel condensation, Microwave irradiation
The landscape of European science communication
Authors: Davies Sarah Rachael , Franks Suzanne , Roche Joseph , Schmidt Ana Lucia , Wells Rebecca , Zollo Fabiana
Published: May 2021

European science communication project QUEST surveyed and reviewed different aspects of European science communication, including science journalism, teaching and training in science communication, social media activity, and science in museums. This article draws together themes that collectively emerge from this research to present an overview of key issues in science communication across Europe. We discuss four central dynamics — fragmentation within research and practice; a landscape in transition; the importance of format and context; and the dominance of critical and dialogic approaches as best practice — and illustrate these with empirical material from across our datasets. In closing we reflect upon the implications of this summary of European science communication.
Exploring the digital media ecology: insights from a study of healthy diets and climate change communication on digital and social media
Authors: Weitkamp Emma , Milani Elena , Ridgway Andy , Wilkinson Clare
Published: May 2021

This study explores the types of actors visible in the digital science communication landscape in the Netherlands, Serbia and the U.K. Using the Koru model of science communication as a basis, we consider how science communicators craft their messages and which channels they are using to reach audiences. The study took as case studies the topics of climate change and healthy diets to enable comparison across countries, topics and platforms. These findings are compared with the results from a survey of over 200 science communication practitioners based in these countries. We find that although traditional media are challenged by the variety of different new entrants into the digital landscape, our results suggest that the media and journalists remain highly visible. In addition, our survey results suggest that many science communicators may struggle to gain traction in the crowded digital ecology, and in particular, that relatively few scientists and research institutions and universities are achieving a high profile in the public digital media ecology of science communication.
Principles of corporate governance as the basis for the formation of the strategic advantage of enterprises in the construction industry
Authors: Volkov Roman
Published: May 2021

The classical interpretation of the principles of corporate governance in terms of effectiveness is important for understanding the economic essence of the management system and its evaluation. Constantly changing socio-economic, epidemiological and geopolitical conditions make the problem of updating the principles of corporate governance important for the clarification of the requirements to be met to ensure a strategic advantage in the construction industry and to maintain competitiveness in the course of the life cycle of an investment construction project and in the process of the long-term construction facility operation. This statement is quite logical, because the focus of the economic science on understanding the principles of corporate governance is especially strengthened during periods of interphase cyclical transitions, triggered by the activation of an economic reform, accompanied by an increase in the uncertainty of business conditions. The project format of modern investment and construction activities becomes the dominant form of its implementation due to the high potential of integration with targeted federal and regional programs and as a result of the adequacy of the task of resource management at each stage of the project life cycle, which in turn allows to effectively allocate resources in time and space.
Distopia, angústia de aniquilamento e a radical poética das relações
Authors: Kiffer Ana Paula Veiga , Patricio Fernandes Mariana
Published: May 2021

O presente artigo pensa a distopia sob a égide da angústia de aniquilamento (Mbembe, 2016), e busca refletir como tal noção desafia o surgimento de poéticas da relação (Glissant, 1990)  como modo de criação dos espaços literário (Blanchot, 1955), utópico e heterotópico (Foucault, 2009) em sociedades cujo passado colonial, e as incursões de cunho autoritário, perpetraram-se ao longo de séculos, como é o caso da sociedade brasileira. A hipótese primordial é a de que, nesses contextos, os espaços de distopia se estabelecem como o início, e não como o fim de tudo, vindo a ser um dos operadores fundacionais de um lugar (utópico ou heterotópico?) inventado pelo outro, o colonizador. A angústia de aniquilamento é a ferramenta primordial para a construção desse lugar e dessa cena (que a literatura irá propagar), e dos laços sociais e os efeitos de divisão espacial (social) e discursiva subsequentes. O artigo buscará, nesse sentido, colocar em questão a noção contemporânea de distopia – muito presente nas narrativas sobre o fim do mundo e na aparição dos messianismos negativos da contemporaneidade no contexto especifico da formação das sociedades coloniais, mas não sem deixar de observar alguns estratos estético-políticos onde uma poética da relação burla esse desenho nas sociedades pós-coloniais.
Survival by Promise: Dystopian Fiction as Denouncer of the Capitalocene
Authors: Marks de Marques Eduardo
Published: May 2021

The rise of dystopian fiction in the past forty years is revealing of sociopolitical anxieties of the present, many of which can be interpreted as consequences of a capitalist form of organization. Through those narratives, literature has the power to make explicit such tensions, especially those now brought together by the contemporary perception of the Capitalocene. The objective of this paper, thus, is twofold: to discuss the possibilities of acknowledging dystopian fiction as an autonomous genre, and to examine how it exposes the ever-dynamic machinations of capitalism. To that end, several examples from modern and contemporary dystopian novels in English are presented and discussed.
Unlocking employee’s green behavior in fertilizer industry: the role of green HRM practices and psychological ownership
Authors: Waqas Muhammad , Yahya Farzan , Ahmed Ammar , Rasool Yasir , Hongbo Li
Published: May 2021

The engineering of agrochemicals and inorganic fertilizers indirectly facilitates the emissions of NO2 and CO2. The extensive use of pesticides and inorganic chemical fertilizers has drawn the world’s attention to green practices. Grounded on the ability-motivation-opportunity (AMO) theory, we investigated the effect of green human resource management (GHRM) practices on employees’ green behavior with the mediating role of psychological ownership. We applied the partial least square structural equation modeling (PLS-SEM) technique to 279 responses acquired from the fertilizer manufacturing firm employees. The results show that GHRM practices (green competence building, green motivation enhancing, and green employee involvement practices) significantly improve employee green behavior. Additionally, GHRM practices enhance the sense of ownership of nature among employees due to which they involve themselves proactively in eco-friendly activities and behavior.
The Transformational Path Ahead: Competency-Based Medical Education in Family Medicine
Authors: Holmboe Eric S.
Published: May 2021

Abstract: Competency-based medical education (CBME) is an outcomes-based approach that has taken root in residency training nationally and internationally. CBME explicitly places the patient, family, and community at the center of training with the primary goals of concomitantly improving both educational and clinical outcomes. Family medicine, as the foundational primary care discipline, has always embraced the importance of linking training with health system needs and performance since its inception. While CBME is no longer a new concept, full implementation of this outcomes-based approach has been daunting and challenging. Gaps in the effectiveness, safety, equity, efficiency, timeliness, and patient/family centeredness of health and health care in the United States continue to be persistent and pernicious. These gaps summon family medicine and the entire graduate medical education system to take stock of its current state and to examine how more fully embracing an outcomes-based educational approach can help to close these gaps. This article provides a brief history of the CBME movement, and more importantly, its key underlying educational principles and science. I will explore the key inflection points of progress, including identifying core CBME components, introduction of competency Milestones, experimental pilots of time variable training, advancements in mastery-based learning, and advances in work-based assessment, within the context of family medicine. I will conclude with suggestions for accelerating the adoption and implementation of CBME within family medicine residency training.
Method of Teaching Arabic Language in Program Diniyah Formal (PDF) at Pondok Pesantren Al-Mubarak Wonosobo/طريقة تعليم اللغة العربية بتربية الدينية الرسمية فى معهد المبارك وونوسوبو
Authors: Kurniasih Novita
Published: May 2021

This study aims to find out Arabic language learning method at Pondok Pesntren Al-Mubaarak Wonosobo year lesson 2018/2019. This research uses qualitative type. Located at the Islamic boarding school Al-Mubaarak Wonosobo in January 2019-March 2019. The subject in this study is the Arabic language teacher and students at the Islamic boarding school Al-Mubaarak Wonosobo. Methods of collecting data with observations, interviews and documentation. Test the validity of the data by using source triangulation. Data analysis starts with data collection, data reduction and data presentation and delivery.The conclusion of this research is the method of learning Arabic at the Islamic boarding school Al-Mubaarak Wonosobo by using method Grammer Translation, method of audio lingual, direct method. and elektik method.
The Pedagogical Competence Of Arabic Language Teachers In Teaching Blind Students/ الكفاءة التربوية لمعلم اللغة العربية في تعليم التلاميذ المكفوفين
Authors: Purwaningsih Candra
Published: May 2021

This study aims to examine the competence of Arabic teachers in teaching blind students. Learning for the visually impaired certainly requires special competencies for teachers so that students get like other students. The approach used in this research is descriptive qualitative. The results of this study indicate that several competencies must be possessed by Arabic language teachers, especially in teaching blind students, including preparation, implementation, and evaluation. In the preparation contained in the lesson plan, there is no lesson plan specifically intended for blind students, but in the implementation and evaluation of learning the teacher uses a special strategy in teaching blind students.
The Implementation of Inclusive Education in Arabic Learning for Blind Students/ تنفيذ التربية الشاملة في تعليم اللغة العربية للتلاميذ المعاقين ضعف البصر
Authors: Maftuhaturohmah Maftuhaturohmah
Published: May 2021

Every citizen has the right to education. Likewise, the right to teach Arabic, which is one of the subjects taught in schools, is not only taught to ordinary students, but also to students with physical limitations. The purpose of this study was to describe the implementation of Arabic language learning in an inclusive class. Learning Arabic in an inclusive classroom is a general class between ordinary students and students with special needs (visually impaired). In learning Arabic in an inclusive class, teachers experience difficulties because they do not have special teaching skills in an inclusive class. The readiness of teachers in preparing teaching materials that can be accessed by blind students is the key to the success of learning Arabic for blind students.
Multiple cystic lesions after treatment for pulmonary cryptococcosis
Authors: Taketa Tomoyo , Nakamura Takahito
Published: May 2021

Pulmonary cryptococcosis presents as various radiological manifestations
depending on the immunological status of the host. The most common chest
radiographic findings include single or multiple nodules. Herein, we
present a rare case of pulmonary cryptococcosis in a patient with
rheumatoid arthritis presenting as multiple cystic lesions that enlarged
after treatment.
Age alone is not a barrier to concurrent chemoradiotherapy for advanced head and neck cancer
Authors: Sexton Gerard , Walsh Paul , Moriarty Frank , O'Neill James
Published: May 2021

Objectives To evaluate the benefits imparted by concurrent
chemoradiotherapy (CCRT) and chemotherapy of any form to elderly head
and neck cancer (HNC) patients in Ireland. Secondary outcomes included
comparison of these benefits to the adult population and subgroup
analysis by site. Design, setting, and participants A retrospective
cohort study was conducted using 20 years of cancer registry data
provided by the National Cancer Registry of Ireland. All HNC diagnosed
from 1994-2014 were included. Cox multivariate regression analysis was
applied to test for the benefits of CCRT and chemotherapy of any form in
HNC. The primary outcome measures were cancer-specific and all-cause
survival in months. Results Survival analysis showed an overall benefit
to the use of CCRT in patients with advanced disease over 65 years,
particularly when used for hypopharyngeal, oral cavity, oropharyngeal,
and laryngeal malignancy, though the latter did not achieve statistical
significance. Chemotherapy of any form conferred a survival benefit in
elderly patients with hypopharyngeal, laryngeal, nasopharyngeal, and
oropharyngeal cancer. Conclusion CCRT and chemotherapy of any form
confer significant survival benefits to appropriately selected elderly
HNC patients and should therefore not be withheld solely on the basis of
age.
Co-delivery of Curcumin and Bioperine via PLGA Nanoparticles to Prevent Atherosclerotic Foam Cell Formation
Authors: Pillai Sindhu C , Borah Ankita , Le Minh Nguyen Tuyet , Kawano Hiroaki , Hasegawa Kouichi , Kumar D. Sakthi
Published: May 2021

Cholesterol-rich arterial plaques characterize atherosclerosis, a
significant cause of heart disease. Arterial plaques upregulate
inflammatory cytokines secreted by the macrophages that finally become
cholesterol-laden foam cells. Nutraceuticals have received attention
over the years, demonstrating potential benefits towards treating and
preventing cardiovascular diseases (CVD), including atherosclerosis.
Curcumin, a potent polyphenol present in Curcuma longa, showed
remarkable anti-atherosclerotic activity via anti-inflammatory and
anti-oxidative properties. The bioavailability and low water solubility
of curcumin limit its clinical translational purposes. These issues can
be circumvented effectively by nano-drug delivery systems that can
target atherosclerotic plaque sites. In this work, we chose to use
curcumin and a natural bioenhancer called Bioperine (derived from Piper
nigrum) inside a polymeric nano-drug delivery system for targeting
atherosclerotic plaque sites. We selected two different ratios of
curcumin: Bioperine to study its comparative effect on the inhibition of
oxidized low-density lipoprotein (Ox-LDL) induced foam cell formation
and investigated the therapeutic efficacy in THP-1 monocyte-derived
macrophages via different in vitro cell studies. Our studies
demonstrated that Bioperine administration alongside curcumin via PLGA
nanoparticles (NPs) imparts a reduction in macrophage-mediated foam cell
formation, relative cholesterol content, and the inflammatory pathways
when administered as preventive medicine, highlighting the importance of
natural-based compounds towards the therapeutic intervention against the
atherosclerotic activity.
Sleep Apnea Screening in Children with Sickle Cell Anemia.
Authors: Flores-Oria Carlos , Stark James , Mosquera Ricardo , Brown Deborah , Menon Neethu , Sharma Kamal , Gonzaales Traci , Nguyen Trinh , Jon Cindy , Emanuel Hina , Yadav Aravind
Published: May 2021

Background: Children with Sickle-Cell Anemia (SCA) are at high risk for
obstructive sleep apnea (OSA). Screening for OSA is therefore
recommended by current guidelines but no specific method described. The
Pediatric Sleep Questionnaire (PSQ) is a validated detection tool for
OSA in children. We assessed the utility of PSQ to screen for OSA in
snoring children with SCA. Methods: A prospective study in children with
SCA, aged 4 - 18 years. Subjects were assessed for snoring and PSQ
administered at the same visit. All snoring children were then referred
for polysomnography (PSG). Results: A total of 106 subjects were
screened. Mean age was 10.5 years and 47.2% male. Snoring prevalence
was 51/106 (48.1%). In the snoring group, OSA was detected in 83.9%
(AHI ≥ 1.0/h) and 22.6% (AHI ≥ 5.0/h), respectively. Sensitivity and
specificity of PSQ in snoring children was 46.2% and 20.0% (AHI ≥
1.0/h), and 57.1% and 50.0% (AHI ≥ 5.0/h), respectively. Physician
assessment of snoring had a high sensitivity of 70.3% but low
specificity of 58.4% (AHI ≥1.0/h), and 87.5% and 41.5% (AHI ≥ 5.0/h),
respectively. Conclusion: PSQ is a poor screening tool for detection of
OSA in snoring children with SCA. Physician assessment of snoring
however could be an initial approach prior to polysomnography.
The Important Role of the Associative and the Deductive Approaches in the Study of Bioactive Glasses
Authors:   Division of Clinical Medicine Science, Weifang Medical University, Weifang, China, Wang Wenhao , Zhai Zhaohui ,   Division of Plastic Surgery, Weifang Medical University, Weifang, China, Wang Ruohan ,   Division of Clinical Medicine Science, Weifang Medical University, Weifang, China, Zhang Xiaopei ,   Division of Clinical Medicine Science, Weifang Medical University, Weifang, China, Li Yanyan ,   Division of Plastic Surgery, Weifang Medical University, Weifang, China, Li Yuli ,   Division of Plastic Surgery, Weifang Medical University, Weifang, China
Published: May 2021

The associative and the deductive approaches play an important role in learning activities, which is an indispensable section in the whole process of cognition. This paper discusses the associative and deductive approaches in the study of the bioactive glasses, and analyzes the contingency and inevitability in the research of bioactive glasses. Thus, the philosophy and science as the whole cannot be separated, these two are auxiliary to each other for achieving current success.
Video-assisted thoracoscopic surgery for primary hyperparathyroidism with ectopic parathyroid adenoma in thymus
Authors: Jokic Radoica , Antic Jelena , Vorgucin Ivana , Stajevic Mila , Nikin Zoran , Zeravica Radmila , Lukic Ivana
Published: May 2021

Introduction. Primary hyperparathyroidism is rare pathology in children (2?5:100,000). In more than 85% of patients, a single adenoma is present, and its extirpation is usually the only treatment a patient requires. In approximately 15?80% of cases, ectopic mediastinal parathyroid tissue can be found inside the thymus. Case outline. Our patient was a 13-year-old boy, who presented with multiple bone fractures in the previous period of time, and fatigue. Parathyroid hormone levels preoperatively were extremely high (1320 pg/ml ? more than 19 times higher than normal). Serum calcium was also elevated (total 3.55 mmol/l; ionized 1.41 mmol/l). He was examined and diagnosed as primary hyperparathyroidism by a pediatric endocrinologist. Imaging procedures for the preoperative localization of parathyroid adenomas were done (99mTc sestamibi scintigraphy and magnetic resonance imaging suggested ectopic mediastinal parathyroid adenoma). The patient underwent video-assisted thoracoscopic surgery procedure. After exploration of the mediastinum and chest, no ectopic parathyroid tissue was found, so total thoracoscopic thymectomy was performed. Final pathological section confirmed parathyroid adenoma inside the thymus. Conclusion. We believe that if no parathyroid tissue is found during surgical exploration of mediastinum, in a child with preoperatively detected parathyroid adenoma in anterior mediastinum, recommendation is to think about possible intrathymic localization and consider removing the thymus. Greater sample size is necessary for higher reliability of this statement.
Entrelaçamentos entre Histórias de Vida de Mulheres Aprisionadas: Dar a Palavra, Aguçar a Escuta
Authors: Veleda Gomes Juniélen , Lidorio de Mattia Jaqueline , Castro Camozzato Viviane
Published: May 2021

O presente artigo parte do seguinte questionamento: De que modos mulheres aprisionadas em Bagé contam suas histórias de vida e, ao mesmo tempo, a partir de que condições estas mesmas histórias se entrelaçam? O objetivo principal é dar voz a essas mulheres privadas de liberdade para problematizar as condições sociais e culturais que se incorporam às histórias de vida das apenadas. O caminho metodológico partiu de autobiografias, cujas escritas foram efetuadas em cadernos pelas próprias detentas e posteriormente lidas e analisadas. Tivemos a intenção de dar voz a elas através de escritas individuais, tendo em vista que a escrita é uma das vias que possibilita a reflexão sobre suas próprias vidas. A pesquisa traz desde narrativas das vidas pré-cárcere até uma análise de suas vidas, enumerando alguns fatores quanto à ineficácia e ressocialização da prisão bem como a ausência de uma educação que qualifique essas mulheres. As marcas de gênero são algo presente no decorrer de toda a discussão, uma vez que as mulheres parecem submetidas ao domínio do “mundo masculino”, traduzido nas relações de violência estabelecidas por parte dos homens, pelo abandono afetivo, financeiro e, ainda, devido ao fato das mulheres aprisionadas estarem, em sua maioria, na prisão, devido a serem levadas a traficar a partir de figuras masculinas.
Diseño y validación de una escala para medir la gestión de la identidad digital
Authors: Huerta Patraca Gustavo Antonio , Torres Gastelú Carlos Arturo , Lagunes Domínguez Agustín
Published: May 2021

La gestión de la identidad digital implica un proceso permanente y consciente del manejo de información personal y contenido que se comparte en Internet, con miras a proteger la privacidad y reputación digital. El objetivo del artículo es describir el proceso de diseño y validación de la escala de percepción titulada IDentifica2.0, creada para medir la gestión de la identidad digital, instrumento empleado para la investigación doctoral en Sistemas y Ambientes Educativos de la Universidad Veracruzana, México. La escala de Likert desarrollada contiene cinco dimensiones: creación de la identidad digital, visibilidad, privacidad y seguridad en Internet, reputación digital y efectos de la identidad digital en el ámbito personal. Se aplicó a 319 estudiantes de la licenciatura en Pedagogía de la Universidad Veracruzana (88 % de mujeres y 12 % de mujeres). Se realizó un análisis factorial exploratorio (AFE) y análisis factorial confirmatorio (AFC) para determinar su validez, que derivó en la eliminación de ítems con baja o nula correlación. Como parte de los resultados, se obtuvo un alfa de 0.80 y un índice Kaiser-Meyer-Olkin (KMO) de 0.728 global para las cinco subescalas. La versión final contiene 32 ítems agrupados en cinco factores. La escala IDentifica2.0 cuenta con un nivel aceptable de confiabilidad y validez para medir la gestión de la identidad digital, y abona al análisis de esta competencia digital.