bluuebunny/crossref_metadata_2025 huggingface dataset:
Activity Monitoring for Toxicity Detection and Management in Patients Undergoing Chemoradiation for Gastrointestinal Malignancies
Authors: Shah Nishant K. , Kim Kristine N. , Grewal Amardeep , Wang Xingmei , Ben-Josef Edgar , Plastaras John P. , Metz James M. , Goel Arun , Taunk Neil K. , Shabason Jacob E. , Lukens John N. , Berman Abigail T. , Wojcieszynski Andrzej P.
Published: February 2022

PURPOSE:

Physical activity is associated with decreased hospitalization during cancer treatment. We hypothesize that activity data can help identify and triage high-risk patients with GI cancer undergoing concurrent chemoradiation.

MATERIALS AND METHODS:

This prospective study randomly assigned patients to activity monitoring versus observation. In the intervention arm, a 20% decrease in daily steps or 20% increase in heart rate triggered triage visits to provide supportive care, medication changes, and escalation of care. In the observation group, activity data were recorded but not monitored. The primary objective was to show a 20% increase in triage visits in the intervention group. Secondary objectives were estimating the rates of emergency department (ED) visits and hospitalizations. Crude and adjusted odds ratios were computed using logistic regression modeling.

RESULTS:

There were 22 patients in the intervention and 18 in the observation group. Baseline patient and treatment characteristics were similar. The primary objective was met, with 3.4 more triage visits in the intervention group than in the observation group (95% CI, 2.10 to 5.50; P < .0001). Twenty-six (65.0%) patients required at least one triage visit, with a higher rate in the intervention arm compared with that in the observation arm (86.4% v 38.9%; odds ratio, 9.95; 95% CI, 2.13 to 46.56; P = .004). There was no statistically significant difference in ED visit (9.1% v 22.2%; P = .38) or hospitalization (4.5% v 16.7%; P = .31).

CONCLUSION:

It is feasible to use activity data to trigger triage visits for symptom management. Further studies are investigating whether automated activity monitoring can assist with early outpatient management to decrease ED visits and hospitalizations.
Popular Piety in Indonesia: “Aestheticization” and Reproduction of Islam
Authors: Wildan Muhammad , Witriani Witriani
Published: February 2022

Globalization and democratization have greatly contributed to the rise of Islamic popular culture especially popular piety in Indonesia. Popular piety can be defined as Muslims’ religious expressions that are driven mostly by their culture or atmosphere rather than their ideology. This article will observe several phenomena of popular piety such as the flourish of the hijâb among middle-class urbanite Muslims, dahwahtainment, the hijrah movement, the burgeoning of ʿumrah pilgrimage with celebrities etc. It is interesting to see these phenomena as part of the process of re-Islamization, secularization, or even post-Islamism. In my view, popular piety is part of the process of public Islam which in turn will generate civil Islam. The phenomena of popular piety will not only be viewed from the perspective of commodification of Islam and consumerism of Muslims, but also as an “aestheticization” of Islam which would foster a much broader interpretation of Islam in Indonesia.
The Muʿtazilism of al-Zamakhsharī: A Bahshamī or a Ḥusaynī?
Authors: Kılavuz Ulvi Murat
Published: February 2022

Al-Zamakhsharī’s Muʿtazilī identity is undisputed, aside from a few isolated assertions or inquiries to the contrary. In fact, alongside historical records that depict him as a loyal Muʿtazilī and even a propagandist for his madhhab, the opinions he expressed and the approaches he employed in his works serve as evidence for this claim. The two Muʿtazilī schools that operated during his time in the Muslim world, in particular in his own region of Khwārazm, were the Bahshamiyyah and the Ḥusayniyyah. Considering this fact, in terms of his theological identity, it could be asserted either that he is a member of one of the Bahshamī or Ḥusaynī schools or that he positions himself “in search of a broadly based, catholic Muʿtazilism” instead of taking a clear stand. This study, while providing partial evidence for the latter claim, argues that his Ḥusaynī identity is rather evident from his ideological stance and opinions.
Financial analysis issues by bankruptcy commissioners
Authors: Krylov Dmitriy
Published: February 2022

In the article are investigated the rules of financial analysis by bankruptcy commissioners in comparison with normative acts, which regulate accounting and financial reporting. The practice of solution by bankruptcy commissioners of problems arising from outdated norms contained in the rules for making financial analysis is investigated. Proposals are made to improve the normative acts governing the making of financial analysis and the content of financial statements.
The Brazilian Legal Amazon Odonatofauna: a perspective of diversity and knowledge gaps
Authors: Garcia Junior Manoel Daltro Nunes , Damasceno Monique Telcia dos Santos , Vilela Diogo Silva , Souto Raimundo Nonato Picanço
Published: February 2022

The Brazilian legal Amazon occupies approximately 61% of its territory, covering a large part of Brazil's biodiversity. This large territorial dimension generates huge gaps in the animal diversity understanding, for example, the poor knowledge regarding the Odonata order. Worldwide, Odonata has almost 6,500 described species, with approximately 1,800 being recorded for the Neotropical region. Data on the Odonata order in the legal Amazon is still scarce, mainly due to its particularities, and little is known about the diversity of dragonflies in some of Brazilian states. Thus, the objective of this study is to present a list of species occurring in the states that make up the Brazilian legal Amazon. The list was made from the analysis of approximately 165 scientific papers, in addition to occurrence records contained in the SiBBr and GBIF databases. 641 species were found, which is equivalent to approximately 69% of the odonatofauna in Brazil. The states with the greatest diversity were Amazonas (n=364), Pará (n=310) and Mato Grosso (n=285). The study also indicated a low level of knowledge of the Odonata order in the states of Tocantins and Maranhão, in addition to the area of ​​the Guianas shields, especially in the states of Amapá and Roraima. Carrying out new inventories and building catalogs is essential for understanding the biodiversity in this region, especially in areas with greater need.
A Theory of Collateral Requirements for Central Counterparties
Authors: Wang Jessie Jiaxu , Capponi Agostino , Zhang Hongzhong
Published: February 2022

This paper develops a framework for designing collateral requirements in a centrally cleared market. Clearing members post collateral—initial margins and default funds—to increase their pledgeable income, thereby committing to risk management. The two types of collateral, however, are not perfect substitutes. By achieving loss mutualization, default funds are economically more efficient than initial margins in aligning members’ incentives for risk management ex ante. The optimal mix of collateral resources balances the efficiency in providing incentives with their relative opportunity costs. Our model predicts increased use of initial margins under stringent capital requirements and of default funds under distressed market scenarios.

This paper was accepted by David Simchi-Levi, finance.
Market Returns and Interim Risk in Mergers
Authors: Heath Davidson , Mitchell Mark
Published: February 2022

A primary concern in mergers and acquisitions is the risk the deal may be cancelled before it is completed. We document that “interim risk” varies asymmetrically with the aggregate market return. Deals tend to be renegotiated when the market rises, but cancelled when the market crashes. These effects are conditional on the method of payment and the contracting stage of the deal, consistent with a mechanism of ex post renegotiation. Variation in interim risk over time alters the method of payment in mergers and the firms that are targeted and acquired.

This paper was accepted by Victoria Ivashina, finance.

Supplemental Material: The e-companion and data are available at https://doi.org/10.1287/mnsc.2022.4315 .
KARAKTERISTIK KEBAHASAAN TOKOH PEREMPUAN DAN LAKI-LAKI DALAM FILM PENDEK
Authors: Cahyani Via , Apriyani Tristanti
Published: February 2022

Research is motivated by the differences in the language used by men and women. Environmental factors and society assume that women are gentle creatures, causing women to be careful about the choice of words in speech. Characteristics of women's language coined by Lakoff (1975) became a reference in this study. The problem discussed in this research is how the characteristics of women's language in the short film Reunian and the characteristics of men's language in the short film Dodit Not Penculik. This study aims to describe the linguistic characteristics of women and men in the two short films. The method used in this paper is descriptive qualitative, and quantitative with the subject of the short film Reunian and the short film Dodit Not The Kidnapper. The data acquisition in this study used the method of observing the free-engagement technique and the note-taking technique. Then the analysis in this study is that women tend to be unsure of their speech because women are very concerned about social norms and protect their self-esteem by using more polite speech.
Designing Online Discussion for HyFlex Learning
Authors: Chen Li-Ling
Published: February 2022

There are pedagogical challenges for the ideal balance of online community building and interaction among students and instructors for HyFlex learning. One of the challenges focuses on how instructors can effectively select and design an online discussion modality to promote positive, vigorous, and encouraging online asynchronous discussion to engage students. This research study adopted an exploratory mixed method approach designed to investigate student’s satisfaction level and academic performance with different interface design platforms for online discussion in HyFlex delivery modality education courses. Study results indicated that different interface design for online discussion platforms had a significant impact on students’ academic achievement for online discussion assessment although there is no significant impact on students’ overall satisfactory levels toward the courses. Implications from the results suggest a need to design and integrate effective online discussion platform to engage students and promote social learning in HyFlex learning environments.
Characterization, fractionation and functional properties of Acacia oerfota gum
Authors: AHMED MUSTAFA ELOBIED , OSMAN MOHAMMED ELMUBARK , HASSAN ELFATIH AHMED
Published: February 2022

Abstract. Ahmed ME, Osman ME, Hassan EA. 2021. Characterization, fractionation and functional properties of Acacia oerfota gum. Asian J Trop Biotechnol 18: 1-12. Thirty gum samples were collected at two locations in around Senga-the state of Sinnar and Wadel Hadad in Aljazeera state, Sudan during season 2015 from Acacia oerfota (15 samples from each location). For the fifteen samples, four composite samples were made for each position by mixing. Chemical, physicochemical, rheological behavior, distribution of molecular weight and molecular weight, and emulsification properties of A. oerfota gum were performed. Ash material (1.12-1.40%), pH (4.55-5.28), specific optical rotation (+65 to +80), color Gardena (0.1-0.3), nitrogen content (0.35-0.77), protein percentage (2.19-3.93%), tannin (268-292 ppm), acid equivalent weight (2941-5357), total uronic acid percentage (3.62-6.60%) The results show the ranges for moisture content (11.8-13.1%), protein percentage (2.19-3.93%), tannin (268-292 ppm), acid equivalent weight (2941-5357), total uronic acid percentage (3.62-6.60%) The percentage of Senga's cationic composition is Calcium 0.287, Potassium 0.131, Strontium 0.004, Iron 0.010. While the percentage of Wadel Hadad location in the caionic composition is Calcium 0.242, Potassium 0.145, Strontium 0.005, Sulphur 0.002, and Iron 0.001. The Rheological Actions of A. oerfota gum demonstrates Newtonian conduct (when applied stress is removed, the molecular form is restored). Values of the mean molecular weight number (Mn) of A. For the two composite sites of Senga and Wadel Hadad, oerfota gum varies between 1.68x105 and 1.80x105 g/mol respectively. The molecular weight determined by gel permeation chromatography (GPC-MALLS) was 6.23x105 g/mole and 9.59x105 g/mole for the two sites. Samples of A. oerfota gum obtained from the Senga location indicate three fractions; Arabinogalactan protein (AGP) with a molecular weight of 1.11% by 4.77x105 mass and Rg 50%. The second and third fractions (Arabinogalactan AG + Glycoprotein GP) are 5.76x105 g/mole molecular weight, 98.89 percent mass. For A, GPC-MALLS. An AGP with a molecular weight of 4.19x105, percent mass 0.84, and Rg 187 is shown by A. oerfota gum samples obtained from Wadel Hadad. The second and third fractions have a molecular weight of 8.24x105 g/mole, 99.16 percent mass (AG + GP). Both emulsions exhibit broad droplet size, displaying a standard distribution of bimodal droplet size with a pronounced shoulder representing weak uniformity and unstable emulsions.
The carotenoid biosynthesis pathway in the asexual intraerythrocytic stages of Plasmodium falciparum
Authors: NORTEY-MENSAH RICHARD , TEYE MARIAN A. , OFORI MICHAEL F.
Published: February 2022

Abstract. Nortey-Mensah R, Teye MA, Ofori MF. 2021. The carotenoid biosynthesis pathway in the asexual intraerythrocytic stages of Plasmodium falciparum. Asian J Trop Biotechnol 18: 13-27. Plasmodium falciparum, like other Apicomplexans, possesses a dormant plastid called the apicoplast. Because it houses metabolic pathways peculiar to the parasite, such as isoprenoid production, this organelle promises a new and promising target for the chemotherapeutic control of malaria. Although the phytoene synthase (PSY) gene has been shown to be critical for carotenogenesis, nothing is known about its evolutionary relationship with P. falciparum and other Apicomplexans. The goal of this work was to identify the evolutionary history and relatedness of the PSY gene in Apicomplexans and other animals, as well as to profile the carotenoids generated in the asexual intraerythrocytic stages of P. falciparum. Fluridone's IC50 and effect on parasite population were determined utilizing in vitro inhibition experiments on the asexual intraerythrocytic stages of P. falciparum. To examine the evolutionary history and relatedness of the PSY gene in Apicomplexans and other taxa, HPLC was used to profile carotenoids created at the asexual phases, and an unrooted phylogenetic tree was built using MEGA 6. Dose-dependent inhibition of parasite population was observed with fluridone treatment on all the asexual stages, with the ring stages being the most vulnerable. The carotenoid profiles revealed that carotenoids are generated cumulatively in P. falciparum throughout the asexual intraerythrocytic phases, with carotenoids such as lycopene, ?-, ?-carotene among those synthesized. The discovery of relatively high quantities of abscisic acid (ABA) in the schizont stages but not in the other stages was an interesting novel finding of this study. This is the first time ABA has been shown to be synthesized by P. falciparum, and additional research into the specific role of ABA in P. falciparum schizont phases would be groundbreaking. The phylogenetic study revealed that the P. falciparum PSY was most closely related to P. reichenowi, a chimpanzee strain of the malaria-causing parasites, supporting the hypothesis that malaria species in humans originated in chimps.
What works to promote research-policy engagement?
Authors: Oliver Kathryn , Hopkins Anna , Boaz Annette , Guillot-Wright Shannon , Cairney Paul
Published: February 2022

Background:

To improve the use of evidence in policy and practice, many organisations and individuals seek to promote research-policy engagement activities, but little is known about what works.

Aims and objectives:

We sought (a) to identify existing research-policy engagement activities, and (b) evidence on impacts of these activities on research and decision making.

Methods:

We conducted systematic desk-based searches for organisations active in this area (such as funders, practice organisations, and universities) and reviewed websites, strategy documents, published evaluations and relevant research. We used a stakeholder roundtable, and follow-up survey and interviews, with a subset of the sample to check the quality and robustness of our approach.

Findings:

We identified 1923 initiatives in 513 organisations world-wide. However, we found only 57 organisations had publicly-available evaluations, and only 6% (141/2321) of initiatives were evaluated. Most activities aim to improve research dissemination or create relationships. Existing evaluations offer an often rich and nuanced picture of evidence use in particular settings (such as local government), sectors (such as policing), or by particular providers (such as learned societies), but are extremely scarce.

Discussion and conclusions:

Funders, research- and decision-making organisations have contributed to a huge expansion in research-policy engagement initiatives. Unfortunately, these initiatives tend not to draw on existing evidence and theory, and are mostly unevaluated. The rudderless mass of activity therefore fails to provide useful lessons for those wishing to improve evidence use, leading to wasted time and resources. Future initiatives should draw on existing evidence about what works, seek to contribute to this evidence base, and respond to a more realistic picture of the decision-making context.
Mixture fraction measurement in turbulent non-premixed MILD jet flame using Rayleigh scattering
Authors: Sahoo Abinash , Ramachandran Aravind , Narayanaswamy Venkateswaran , Lyons Kevin M.
Published: February 2022

Turbulent combustion of jet flames in a hot diluted coflow of
combustion products is conducive to the transition from conventional
flamelet combustion to a regime of moderate or intense low oxygen
dilution (MILD) combustion, which is commonly characterized by a very
low emission and noise. MILD combustion is also characterized by
distributed combustion where the net heat release is positive across
the entire combustion domain. The turbulence/chemistry interactions in
this regime that determine the flame structure, local temperature, and
species distribution critically depend on the mixture fraction and
scalar dissipation fields. However, there are no experimental tools to
measure the mixture fraction field in a distributed (MILD) combustion
regime. The present work offsets this limitation by demonstrating a
Rayleigh scattering-based approach to measure mixture fraction in a
turbulent ethylene MILD combustion zone. 1D counterflow flame
simulations enabled mapping the locally calibrated Rayleigh scattering
fields to mixture fractions in the fuel-rich regions. This approach
also shows very low sensitivity to the local temperature and
composition. Overall, the results provide compelling evidence that the
distributed heat release does not significantly impact the turbulent
processes of the flow-field for the conditions examined. The
measurement uncertainty from this approach and its extension to more
complex fuels are also discussed. The present technique is limited to
mildly turbulent, fully MILD/distributed flame with representative
scalar dissipation rates.
Optical-feedback cavity ring-down spectroscopy for NO2 extinction coefficient measurement using a continuous wave laser diode
Authors: Cheng Chonghui , Liu Sumei , Qi Haiyang , Hu Pengbing , Ye Pei , Pan Sunqiang
Published: February 2022

Optical-feedback (OF) cavity ring-down spectroscopy consisting of a linear cavity is developed by employing a continuous wave laser diode (LD) with multi-longitudinal modes. Due to the OF effect caused by the cavity output laser back into the LD, the laser frequency is locked, and the intracavity laser intensity is enhanced. We use different concentrations of

N
O

2

gases to test the apparatus, and the results show good agreement with theoretical values. Owing to the compactness of the laser source and high detection accuracy, the device can be used for detection of low-concentration absorbent gases in the environmental monitoring field.
Self-adjustment of spectral components to object wave field extraction in off-axis digital holography
Authors: Leal-León Nicómedes , Medina-Melendrez Modesto , Flores-Moreno J. M. , Rubio-Astorga Guillermo J. , Cabanillas-Noris Juan C.
Published: February 2022

In this paper, we introduce a positioning system to self-adjust the spectral components of holograms recorded by an off-axis digital holography setup. The incidence angle of the reference arm is carried out by two motorized actuators controlled by an algorithm that automatically adjusts it to avoid the overlapping of the spectral components. The right positioning of the spectral components allows selection of a spectral region to extract only the virtual component so that, after an inverse Fourier transformation, the object wave field can be obtained, thus eliminating the undesired components and increasing the image quality of the reconstructed image.
Elucidating multi-input processing 3-node gene regulatory network topologies capable of generating striped gene expression patterns
Authors: Arboleda-Rivera Juan Camilo , Machado-Rodríguez Gloria , Rodríguez Boris A. , Gutiérrez Jayson
Published: February 2022

A central problem in developmental and synthetic biology is understanding the mechanisms by which cells in a tissue or a Petri dish process external cues and transform such information into a coherent response, e.g., a terminal differentiation state. It was long believed that this type of positional information could be entirely attributed to a gradient of concentration of a specific signaling molecule (i.e., a morphogen). However, advances in experimental methodologies and computer modeling have demonstrated the crucial role of the dynamics of a cell’s gene regulatory network (GRN) in decoding the information carried by the morphogen, which is eventually translated into a spatial pattern. This morphogen interpretation mechanism has gained much attention in systems biology as a tractable system to investigate the emergent properties of complex genotype-phenotype maps. In this study, we apply a Markov chain Monte Carlo (MCMC)-like algorithm to probe the design space of three-node GRNs with the ability to generate a band-like expression pattern (target phenotype) in the middle of an arrangement of 30 cells, which resemble a simple (1-D) morphogenetic field in a developing embryo. Unlike most modeling studies published so far, here we explore the space of GRN topologies with nodes having the potential to perceive the same input signal differently. This allows for a lot more flexibility during the search space process, and thus enables us to identify a larger set of potentially interesting and realizable morphogen interpretation mechanisms. Out of 2061 GRNs selected using the search space algorithm, we found 714 classes of network topologies that could correctly interpret the morphogen. Notably, the main network motif that generated the target phenotype in response to the input signal was the type 3 Incoherent Feed-Forward Loop (I3-FFL), which agrees with previous theoretical expectations and experimental observations. Particularly, compared to a previously reported pattern forming GRN topologies, we have uncovered a great variety of novel network designs, some of which might be worth inquiring through synthetic biology methodologies to test for the ability of network design with minimal regulatory complexity to interpret a developmental cue robustly.
Matrix metalloproteinases and their inhibitors in pediatric severe acute pancreatitis
Authors: Vitale David S. , Lahni Patrick , Hornung Lindsey , Thompson Tyler , Farrell Peter R. , Lin Tom K. , Nathan Jaimie D. , Wong Hector R. , Abu-El-Haija Maisam
Published: February 2022

Background

Acute pancreatitis (AP) is increasing in incidence in adult and pediatric patients. Identification of patients at high risk for progression to severe acute pancreatitis (SAP) is crucial, as it can lead to increased mortality and health system cost. Matrix metalloproteinases (MMPs) are endopeptidases which degrade extracellular matrix proteins and increase activity of pro-inflammatory cytokines. Tissue inhibitors of metalloproteinases (TIMPs) regulate MMP activity. Prior limited studies of MMPs and TIMPs have found some to be associated with development of SAP. The aim of this study was to further investigate the role of MMPs and TIMPs in detecting pediatric patients at risk for developing moderately severe AP or SAP.

Methods

Plasma samples were prospectively collected for patients <21 years of age presenting with AP between November 2015 and October 2019, along with healthy controls. Bead-based multiplex assays were utilized to test levels of 12 MMPs and TIMPs.

Results

Samples were collected from 7 subjects who developed SAP, 7 with moderately severe AP, 45 with mild AP and 44 healthy controls. MMP-9 (p = 0.04) and TIMP-1 (p = 0.01) levels were significantly higher in SAP patients. A multivariable logistic regression model using MMP-9 and TIMP-1 predicted SAP (AUROC 0.87, 95% CI 0.76–0.98).

Conclusion

We have demonstrated that MMP9 and TIMP1 levels are increased at AP presentation in pediatric patients who developed SAP during the course of illness. Further studies are needed to validate the use of MMPs and TIMPs as predictive tools for development of SAP in pediatric pancreatitis.
Cannabis use and suicidal ideation among youth: Can we democratize school policies using digital citizen science?
Authors: Katapally Tarun Reddy
Published: February 2022

Background

School policies and programs are important in preventing Cannabis use among youth. This study uses an innovative digital citizen science approach to determine the association between Cannabis use and suicidal ideation among youth while investigating how school health policies mediate this association.

Methods

The study engaged 818 youth (aged 13–18 years) and 27 educators as citizen scientists via their own smartphones. Youths responded to time-triggered validated surveys and ecological momentary assessments to report on a complex set of health behaviours and outcomes. Similarly, educators’ reported on substance misuse and mental health school policies and programs. Multivariable logistic regression modeling and mediation analyses were employed.

Results

412 youth provided data on substance misuse and suicidal ideation. Cannabis use and other factors such as bullying, other illicit drug use, and youth who identified as females or other gender were associated with increased suicidal ideation. However, school policies and programs for substance misuse prevention did not mediate the association between Cannabis use and suicidal ideation.

Conclusions

In the digital age, it is critical to reimagine the role of schools in health policy interventions. Digital citizen science not only provides an opportunity to democratize school policymaking and implementation processes, but also provides a voice to vulnerable youth.
An integrated data framework for policy guidance during the coronavirus pandemic: Towards real-time decision support for economic policymakers
Authors: Dörr Julian Oliver , Kinne Jan , Lenz David , Licht Georg , Winker Peter
Published: February 2022

Usually, official and survey-based statistics guide policymakers in their choice of response instruments to economic crises. However, in an early phase, after a sudden and unforeseen shock has caused unexpected and fast-changing dynamics, data from traditional statistics are only available with non-negligible time delays. This leaves policymakers uncertain about how to most effectively manage their economic countermeasures to support businesses, especially when they need to respond quickly, as in the COVID-19 pandemic. Given this information deficit, we propose a framework that guided policymakers throughout all stages of this unforeseen economic shock by providing timely and reliable sources of firm-level data as a basis to make informed policy decisions. We do so by combining early stage ‘ad hoc’ web analyses, ‘follow-up’ business surveys, and ‘retrospective’ analyses of firm outcomes. A particular focus of our framework is on assessing the early effects of the pandemic, using highly dynamic and large-scale data from corporate websites. Most notably, we show that textual references to the coronavirus pandemic published on a large sample of company websites and state-of-the-art text analysis methods allowed to capture the heterogeneity of the pandemic’s effects at a very early stage and entailed a leading indication on later movements in firm credit ratings. While the proposed framework is specific to the COVID-19 pandemic, the integration of results obtained from real-time online sources in the design of subsequent surveys and their value in forecasting firm-level outcomes typically targeted by policy measures, is a first step towards a more timely and holistic approach for policy guidance in times of economic shocks.
Synthesis, Anticancer and Antiviral Activity Studies of 1,3,4-Oxadiazoles: A Review
Authors: DEVI K. , RAO A. SRINIVASA , PRASAD Y. RAJENDRA , RAJU K. , MOUNIKA D. GEETA
Published: February 2022

1,3,4-Oxadiazole is a five membered heterocyclic nucleus and a versatile lead structure, where its derivatives showed broad and potent
biological functions especially as anticancer and antiviral agents which are associated with various mechanisms such as inhibition of
different enzymes, kinases and growth factors. The present review summarizes various synthetic procedures and highlights the targeted
inhibitory activities of 1,3,4-oxadiazoles as potential anticancer and antiviral agents along with their structure activity relationship.
Molecular modeling and pharmacokinetic studies on 1,3,4-oxadiazoles proved a change in their polarity, flexibility and metabolic stability
led to their improved biological activity potential. Among all the substituted 1,3,4-oxadiazoles, the mono- and 2,5-disubstituted derivatives
showed considerable biological activities especially as anticancer and antiviral agents. Hence, scientists/researchers considered these as
future lead molecules to treat cancer and viral infections along with other diseases. In future, the oxadiazole motif is likely to be incorporated
in various other therapeutic molecules.
Recent Developments in Textile Reinforced Polymer Composites
Authors: SULOCHANI R.M.N. , JAYASINGHE R.A. , NILMINI A.H.L.R. , Priyadarshana Gayan
Published: February 2022

This article provides an overview of using textile materials as reinforcement in polymer composites. A considerable amount of research
studies on this topic have been conducted to date. The different types of textile materials and polymer matrices used in composite
development have been discussed. The fabrication techniques used in the development of composites, the properties, testing methods and
the specific standards have been critically reviewed. Furthermore, the suitable applications of textile reinforced polymer composites are
reviewed. This review highlights the potential of textile materials in polymer matrices as reinforcement for various applications, including
automotive, aeronautical, defence, construction industries, etc.
Psycho - physiological aspects & effect on resporatory system through Naturopathy on children age group 5-12 yrs
Authors: Desai Dr Shilpa
Published: February 2022

POSITIVELY LINK TO GLOBAL WARMING   TITLE OF THE THESIS PSYCHO-PHYSIOLOGICAL ASPECT AND ITS EFFECT ON RESPIRATORY SYSTEM THROUGH NATUROPATHY ON CHILDERN AGE GROUP 5-12 YRS – POSITIVELY LINK TO GLOBAL WARMING A THESIS SUBMITTED TO THE SHRI JAGDISH PRASAD JHABARMAL TIBREWALA UNIVERSITY, VIDYANAGARI, JHUNJHUNU, RAJASTHAN. FOR THE DEGREE OF DOCTOR OF PHILOSOPHY IN (INTERDISCIPLINARY) SHILPA N. DESAI REG.NO. - 20114552 UNDER THE GUIDANCE OF Dr. NARENDRA V. DESHMUKH DEPARTMENT OF PSYCHOLOGY SHRI JAGDISH PRASAD JHABARMAL TIBREWALA UNIVERSITY, VIDYANAGARI, JHUNJHUNU, RAJASTHAN – 333001 Year 2013 SUMMARY IN BRIEF: Introduction The present study’s aim is at finding out the effect of ‘Naturopathy’ on Physiological and Psychological factor on Respiratory system of children in age group 5 – 12 years, when environmental conditions are unfavourable and averse to healthy living. The Physiological aspect has been measured by Body parameter like Age, Height, Weight, BMR, BMI. Vital parameter being measured by using laboratory instrument; Oxymeter test (O2), Fingertip Begin 2B FDA 510(k), Spirometer test (EFEV), Hudson cc/sec, Peak flow meter test (PFEV) Personal Best Full range peak flow meter(60-810 L/min), Psychological parameter is tested by selecting tool constructed by Jadgish and A K Srivastava, i.e. Mental health inventory, which integrate the personality, autonomy group oriented attitudes and environmental mastery
Narrativas de professores formadores: práticas pedagógicas no ensino com a oralidade e a escrita na perspectiva dos multiletramentos
Authors: Teno Neide Castilho de Araújo , Oliveira Edinéia Leite dos Santos , Zeviani Maristela
Published: February 2022

Este estudo vincula-se ao projeto “Memórias de professores: diálogos sobre o Letramento e o ensino da Língua Portuguesa - etapa II” objetivando reflexão acerca do ensino da língua portuguesa nas escolas públicas. Analisa o ensino da oralidade e escrita enquanto prática docente na perspectiva do multiletramento. Objetiva compreender práticas pedagógicas dos professores em formação em Letras, por meio da análise de fragmentos de narrativas orais e escritas desses professores. Utilizou-se metodologia da análise de conteúdo de Bardin (2013) para análise dos dados com recorte para relação ensino e prática pedagógica, prática de ensino de textos orais e escritos, oralidade e escrita. Utilizou-se os teóricos Bakhtin/Volochínov (1997; 2014), Tfouni (2010), Josso (2010), Marcuschi, (2001), entre outros. Como resultado, constatou-se que os professores dominam observações da oralidade e da escrita com gêneros multimodais na construção de sentido relaciondo-os aos usos sociais da linguagem e articulação entre experiências vivenciadas em sala de aula.
Análise comparativa dos programas de Matemática: cursos técnicos industriais versus colégio (1942-1965)
Authors: Maciel Paulo Roberto Castor
Published: February 2022

A partir de estudos históricos sobre a disciplina de Matemática no ensino secundário, verificou-se uma lacuna com relação à disciplina no ensino industrial. O objetivo do artigo é comparar matemática nos cursos técnicos da Escola Técnica Nacional com a disciplina do 2ºciclo do ensino secundário da época. Para realização da investigação, utilizou-se a história comparada e história das disciplinas escolares. As fontes de pesquisa foram os programas de Matemática, legislação e manuais didáticos. Podemos concluir que, entre as similaridades, temos a forma de ensinar e a nomenclatura de alguns dos conteúdos, e entre as diferenças, a distribuição da disciplina, a carga horária, as finalidades e os manuais.
Estudos em rede sobre os princípios da formação docente na contemporaneidade: uma análise da realidade na UP/Moçambique
Authors: Buque Suzete Lourenço
Published: February 2022

Este artigo tem como objetivo analisar os princípios gerais que orientam a formação de professores na fase contemporânea. Buscamos refletir sobre o como eles permeiam a formação de professores, buscando identificar e compreender se há aproximações com os princípios que orientam a formação de professores na Universidade Pedagógica de Moçambique (UP). A reflexão baseou-se na pesquisa documental e na experiência pessoal, como docente da mesma instituição. A leitura de documentos orientadores aponta para a existência de aproximações, mas também divergências. O desafio está na correta interpretação e na criação de um contexto que favoreça a aplicação dos princípios comuns, sobretudo no que se refere a concepção de educação que cada professor formador defende.
FEMININO MALDITO EM ANTICRISTO, DE LARS VON TRIER
Authors: Antunes Torres Jessé
Published: February 2022

Este ensaio propõe uma leitura do filme Anticristo, de 2009, escrito e dirigido por Lars von Trier, a partir da teoria do imaginário, entendida aqui a partir dos estudos de Durand (2012). Nesse movimento de leitura, este trabalho se aproxima metodologicamente da mitocrítica, embora não a estejamos seguindo à risca. O cinema é tomado enquanto uma tecnologia do imaginário, na medida em que mobiliza imagens e afetos. O filme escolhido é especial, pois opera numa lógica simbólica e imagética, psicanalítica, abandonando o “realismo” para dar lugar ao devaneio, ao sonho e às manifestações do inconsciente. A partir da análise, evidencia-se que regendo o filme encontra-se o imaginário de um feminino maldito herdado dos mitos fundadores judaico-cristãos (Lilith, Eva), que culmina, na Idade Moderna, na figura da bruxa.
RITUAL DO JONGO E O IMAGINÁRIO MÍTICO AFROBRASILEIRO
Authors: Mattos Ricardo
Published: February 2022

Analisa-se o imaginário mítico do ritual afrobrasileiro do jongo. Para o filósofo Eudoro de Souza, o ritual religioso reverbera na sensibilidade e na imaginação de seus protagonistas, expressas em versos, gestos e sons. Assim, investiga-se o jongo como ritual religioso, a partir do método etnográfico da observação participante e a memória oral dos jongueiros. Conclui-se que o imaginário mítico do jongo é composto por objetos de culto (fogueira, tambores e chocalhos), atos rituais (“saravar a ngoma”, “amuntar na calunga”), gestos mágicos (dançar da “pemba”, plantar e colher frutos), imagens míticas (tatu, terra afundada e correnteza marítima) e personagens espirituais (como o “cumba” ou “jongueiro velho”). Tal imaginário institui um canal de comunicação com os espíritos ancestrais e a ritualização de uma morte simbólica, expressa na condição de escravidão e na vinda para os cativeiros brasileiros. Contudo, a presença ancestral permite um renascimento ritual, com a viagem de retorno à mítica Aruanda e a experiência de prosperidade da vida em liberdade.
FACES INSÓLITAS DA IARA
Authors: Mendes Sousa Daniele , Da Silva Rodrigues Danielle , Cordovil da Silva Suellen
Published: February 2022

Este artigo tem como objetivo analisar a personagem Iara no conto “A Iara do Rio Santana”, no livro “Visagens, Assombrações e Encantamentos da Amazônia” (2019), de Walcyr Monteiro (1940-2019). A Iara é uma lenda que faz parte do folclore brasileiro; sendo assim, estudaremos sob uma perspectiva do gótico, insólito ficcional e o fantástico como modo. Além disso, buscamos embasamento nos estudos de Flávio Garcia (2012), que descreve o insólito como uma categoria ficcional comum a variados gêneros literários. Já para Marisa Gama-Khalil (2019) apud Furtado (2011), o fantástico é entendido como um modo que agrega textos e gêneros heterogêneos por meio de um aspecto em comum: o sobrenatural, integrando o conto de fadas, o gótico, o maravilhoso, o estranho, a ficção científica e outras modalidades.  Para complementar nossa base teórica, serão abordadas as ideias de Noël Carroll, especialmente a obra “The philosophy of horror” (1990). Também serão contempladas as obras “Folk-lore Brésilien” (1889), de Frederico José de Santa-Anna Nery e “Lendas Brasileiras” (2015) e “Geografia dos Mitos Brasileiros” (2012), de Câmara Cascudo. Dessa forma, pretendemos explorar a pluralidade que envolve as narrativas dessa personagem pelo viés gótico. Iara é um ser insólito que habita os rios amazônicos, carregando uma assustadora maldição: seu canto hipnotizante e sua beleza mortal a transformam em uma ceifadora de homens, atraindo-os para o fundo das águas.
POVO FILHO DAS ÁGUAS
Authors: Barbosa Barros Randra Kevelyn
Published: February 2022

As literaturas produzidas por escritores indígenas têm disseminado as vozes de diferentes povos originários. Essas escritas abordam filosofias milenares e questionam o apagamento imposto pelo poder hegemônico. Nesse sentido, é fundamental utilizar a tecnologia da escrita alfabética com o objetivo de salvaguardar a memória oral e difundir esses conhecimentos para um público mais amplo. Dentre os autores que têm seguido esse caminho, cabe citar a produção de Kanátyo Pataxó (1997), intitulada Txopai e Itôhã, a qual narra como os indígenas de seu povo surgiram no planeta. Levando em consideração a importância deste livro, busca-se analisar essa história contemplando os elementos verbais e as ilustrações para evidenciar a perspectiva de mundo Pataxó intrinsecamente ligada à água.  Para tanto, será necessário dialogar com a produção teórica indígena que discute importantes categorias críticas para tratar dessas narrativas, tais como escritas-resistência (Adriana Pesca, 2020), memória cultural (Kaká Jecupé, 2020) e histórias de antigamente (Edson Kaxinawá et. al, 1996). Dessa forma, a investigação destaca a importância de os indígenas estarem criando terminologias próprias para se referirem ao seu legado ancestral e contribui para expandir os estudos acerca das escritas Pataxó, as quais revelam que esse povo é filho das águas.
MÉTODO ARQUETIPOLÓGICO E O ESTUDO DAS LITERATURAS INDÍGENAS E AFRODIASPÓRICAS
Authors: Rosa da Costa Heliene
Published: February 2022

Intelectuais indígenas e afrodescendentes costumam ter o valor de suas produções literárias, muitas vezes, relativizado pela crítica tradicional, em razão de estabelecerem profundo vínculo com a oralidade. Entretanto, no mundo grego antigo, berço das civilizações ocidentais, temos notícias dos Aedos, poetas que cantavam hinos e canções, em complexa estrutura autoral: coletiva e com foco na oralidade. A literatura afrodiaspórica dá centralidade às histórias contadas como forma de transição da totalidade dos saberes, pela prática dos griôts. Da mesma forma, as culturas ameríndias recuperam as memórias ancestrais e promovem o fortalecimento da identidade cultural e espiritual pela contação de histórias. O método arquetipológico proposto por Durand (1996) apresenta a vantagem de poder ser associado às diferentes culturas e povos, de maneira sistematizada que pode ser capaz de operacionalizar relações não excludentes entre diferentes aspectos, entre eles, a oralidade e a escrita. Do excerto, podemos concluir que, a partir do emprego desses processos investigativos, torna-se possível dirimir questões valorativas e estigmatizantes nas concepções de povos e culturas diferentes. A metodologia adotada nessa análise é pesquisa interpretativa e documental dos textos literários eu compõem o corpus. Para as análises utilizamos como referencial teórico, autores como Durand, Esra pound, Graça Graúna, Márcia Kambeba, Lia Minápoty, Conceição Evaristo, Cristiane Sobral, Kiusam de Oliveira, Sidarta Ribeiro e Muniz Sodré, entre outros.
IMAGINÁRIO MÍTICO INDÍGENA E AFRICANO - COSMOGONIAS E OUTRAS CRIAÇÕES IMAGINÁRIAS - NA LITERATURA E NAS ARTES.
Authors: Carlos Augusto de Melo  , Zuleide Duarte
Published: February 2022

Conselho Editorial Téssera
PELATIHAN MARKETING ONLINE DALAM MENGHADAPI NEW NORMAL DI DESA TANJUNGTANI, KECAMATAN PRAMBON, KABUPATEN NGANJUK
Authors: Basthomi Imam
Published: February 2022

In early 2020 all countries were affected by Corona virus outbreak (Covid-19). That virus spread fastly so World Health Organization (WHO) announced Pandemic emergeny status. Indonesia government use Physical Distancing, Social Distancing, and Rapid Test to reduce spreading of covid-19. They also instructed their inhabitant to carry out the work from home, study from home, and pray from home programs. The efforts to prevent the transmission of Covid-19 has an impact on various fields, one of them in economic sector. Based on that statement, KKN 144 of UIN Sunan Kalijaga Yogyakarta grup that doing dedication in Tanjuntani Village, Prambon District, Nganjuk Regency hold an Online Marketing Training. The training is intended for businessmen or UMKM and youth in Tanjungtani Village. Aim of that training is to maintain economic condition in there. The dedication method use observation, aproach, interview, and socialization. The result of these activities indicate that businessmen or UMKM have the potential to develop their businesses by aplying Online Marketing knowlegde. By utilizing technology, the impact of covid-19 on economic sector can be reduced.
TEOLOGI LINGKUNGAN; Studi Fenomenologi Gerakan Environmentalisme Komunitas Air Kita Mojoagung
Authors: Khasanah Amilatul , Naibin Naibin
Published: February 2022

In modern era, environmental issues placed with religion are being seriously discussed by academics and some elements of society who are concerned about the problem of ecological crisis, as a result of threat life. The environmentalism movement is to instill consciousness in their reactions to nature. This consciousness of being environmentally friendly is carried out by the Air Kita Mojoagung Community which focuses on the movement of utilizing rainwater. This research aims to describe the religious motivational experience Air Kita Community through the rainwater conservation movement. The study was conducted using a qualitative method with a phenomenological approach that is oriented to data from in-depth interviews, field observations, documentation and literature studies. Classified data presented descriptively analysis. Results the research indicate that although it is seen in the meaning of water capitalization, the factor of religious doctrine is strong in motivating environmental movement. This can be seen in the approach used namely rainwater sholawat festival with the strengthening of the Javanese art tradition of wayang beber and the Javanese Islamic art of gambus misri 9 stars, nadah udan in the realm of praxis which means that rainwater is a blessing and a gift, God’s presence that should not be wasted.
Construcción de Paz, tecnologías de la información y ciudadanías creativas: el caso de la escuela audiovisual Caminos de Paz en Cauca, Colombia
Authors: Gómez Montañez Pablo Felipe , Meza Maya Clara Victoria , Ruiz Moreno Sandra Lucía
Published: February 2022

Este artículo muestra los resultados de la primera fase de implementación de una escuela de comunicación audiovisual, la cual es mediada por tecnologías digitales de la información. Para ello identificamos dos tipos de narrativas. En primer lugar, una sobre los impactos benéficos en el acceso y apropiación de tecnología, y en valores derivados de procesos colaborativos llevados a cabo por los estudiantes para fortalecerse como colectivo social. En segundo lugar, otras que conforman un primer corpus de contenidos, con los cuales la escuela busca narrarse y representarse como caso exitoso de construcción de paz en la región. Nuestra tesis consiste en que dichas narrativas evidencian que los procesos de apropiación de tecnologías de información y comunicación digital llevados a cabo por este grupo de beneficiarios fortalecen procesos de comunicación comunitaria y de ciudadanías creativas, sustentadas en los valores que emergen en medio de relaciones e interacciones colaborativas.