bluuebunny/crossref_metadata_2025 huggingface dataset:
Laboratory and clinical risk assessment to treat myelodysplatic syndromes
Authors: Gidaro Antonio , Deliliers Giorgio Lambertenghi , Gallipoli Paolo , Arquati Massimo , Wu Maddalena Alessandra , Castelli Roberto
Published: December 2018

Myelodisplastic syndromes (MDS) are heterogeneous myeloid disorders characterized by peripheral cytopenias and increased risk of transformation into acute myelogenous leukemia (AML). MDS are generally suspected in the presence of cytopenia on routine analysis and the evaluation of bone marrow cells morphology and cellularity leads to correct diagnosis of MDS. The incidence of MDS is approximately five cases per 100,000 people per year in the general population, but it increases up to 50 cases per 100,000 people per year after 60 years of age. Typically MDS affect the elderly, with a median age at diagnosis of 65–70 years. Here the current therapeutic approaches for MDS are evaluated by searching the PubMed database. Establishing the prognosis in MDS patients is a key element of therapy. In fact an accurate estimate of prognosis drives decisions about the choice and timing of the therapeutic options. Therapy is selected based on prognostic risk assessment, cytogenetic pattern, transfusion needs and biological characteristics of the disease, comorbidities and clinical condition of the patients. In lower-risk patients the goals of therapy are different from those in higher-risk patients. In lower-risk patients, the aim of therapy is to reduce transfusion needs and transformation to higher risk disease or AML, improving the quality of life and survival. In higher-risk patients, the main goal of therapy is to prolong survival and to reduce the risk of AML transformation. Current therapies include growth factor support, lenalidomide, immunomodulatory and hypomethylating agents, intensive chemotherapy, and allogenic stem cell transplantation. The challenge when dealing with MDS patients is to select the optimal treatment by balancing efficacy and toxicity.
Degrowth wächst an Geschlechterperspektiven: Genderaspekte in Degrowth-Konzeptionen und -Praxis
Authors: Dannemann Hauke , Holthaus Anna
Published: December 2018

Trotz zunehmender Anstrengungen finden Genderaspekte der Gestaltung gesellschaftlicher Naturverhältnisse in deutschsprachigen Debatten um Postwachstum und Degrowth wenig Beachtung. In diesem Artikel werden diesbezügliche Leerstellen sowohl auf konzeptioneller Ebene am Beispiel der Postwachstumsökonomik und -ökonomie Niko Peachs als auch in der Praxis der Degrowthbewegung anhand empirischer Forschungsergebnisse in Deutschland aufgezeigt. Ihnen werden Potentiale feministischer Forschung und Praxis für Degrowthkonzepte und -bewegung gegenübergestellt, um die Forderung nach einer emanzipatorischen sozial-ökologischen Transformation, die auch notwendig auf die Überwindung patriarchaler Geschlechterverhältnisse zielen muss, zu Zeiten gesellschaftlicher Regressionstendenzen zu bestärken.
LncRNA TINCR/microRNA-107/CD36 regulates cell proliferation and apoptosis in colorectal cancer via PPAR signaling pathway based on bioinformatics analysis
Authors: Zhang Xuexiu , Yao Jianning , Shi Haoling , Gao Bing , Zhang Lianfeng
Published: December 2018

The present study aims to determine the potential biomarkers and uncover the regulatory mechanisms of the long-noncoding RNA (lncRNA) TINCR/miR-107/CD36 axis in colorectal cancer (CRC). Aberrantly-expressed lncRNAs and differential-expressed genes were identified by analyzing the dataset GSE40967. Gene set enrichment analysis was employed, and Cytoscape software helped in establishing the co-expression network between lncRNAs and genes. Quantitative reverse transcription-polymerase chain reaction (RT-PCR) analysis contributes to examining the expression levels of lncRNA TINCR, miR-107 and CD36. The dual luciferase assay was used to validate the association between miR-107 and lncRNA TINCR or CD36. The EdU incorporation assay was employed, and flow cytometry was employed to detect cell apoptosis with the tumor xenograft model being utilized. Significantly dysregulated lncRNAs and mRNAs were identified. The peroxisome proliferator-activated receptor (PPAR) signaling pathway in CRC tissues was down-regulated. The loss of TINCR expression was associated with CRC progression. The expression levels of the TINCR and CD36 were down-regulated. We identified miR-107 as an inhibitory target of TINCR and CD36. Overexpression of TINCR could inhibit cell proliferation and promote apoptosis. MiR-107 overexpression in CRC cells induced proliferation and impeded apoptosis. A regulatory function of the lncRNA TINCR/miR-107/CD36 axis in CRC was revealed. LncRNA TINCR overexpression exerted suppressive influence on CRC progression through modulating the PPAR signaling pathway via the miR-107/CD36 axis.
Kinetically selective and potent inhibitors of HDAC8
Authors: Schweipert Markus , Jänsch Niklas , Sugiarto Wisely Oki , Meyer-Almes Franz-Josef
Published: December 2018

Histone deacetylase 8 (HDAC8) is an established and validated target for T-cell lymphoma and childhood neuroblastoma. The active site binding pocket of HDAC8 is highly conserved among all zinc-containing representatives of the histone deacetylase (HDAC) family. This explains that most HDACs are unselectively recognized by similar inhibitors featuring a zinc binding group (ZBG), a hydrophobic linker and a head group. In the light of this difficulty, the creation of isoenzyme-selectivity is one of the major challenges in the development of HDAC inhibitors. In a series of trifluoromethylketone inhibitors of HDAC8 compound 10 shows a distinct binding mechanism and a dramatically increased residence time (RT) providing kinetic selectivity against HDAC4. Combining the binding kinetics results with computational docking and binding site flexibility analysis suggests that 10 occupies the conserved catalytic site as well as an adjacent transient sub-pocket of HDAC8.
The Hybrid Real-Time Dispatcher Training Simulator: Basic Approach, Software-Hardware Structure and Case Study
Authors: Suvorov Aleksey , Gusev Alexander , Ruban Nikolay , Andreev Mikhail , Askarov Alisher , Stavitsky Sergey
Published: December 2018

The article presents the Hybrid Real-Time Dispatcher Training Simulator (HRTDTS). The main advantages of this simulator are the adequate simulation of a single spectrum of processes in the object for training – any real electric power system (EPS), as well as the real-time control of the equipment circuit-mode states in modes of the EPS operation. This is achieved by the HRTDTS development within the concept of hybrid simulation, which allows to surpass the modern widely-used simulators based purely on numerical simulation, which do not comprehensively reproduce processes in the EPS and limit the training of certain dispatchers skills. The dispatcher simulator structure and the developed specialized HRTDTS software are demonstrated. The developed dynamic dashboards for monitoring and operating, implementing the circuit-mode states visualization of the equipment or the EPS districts that correspond to specific objects for training, are presented. The special panels that display extended information about the processes in the EPS are also shown in the article. The comparison of simulation results with the data, obtained via RTDS, for the HRTDTS validation was carried out. The practical emergency scenario for the training of dispatching personnel, including the assignment of an emergency situation and the actions of dispatchers to eliminate it, was created for testing and demonstration of the HRTDTS capabilities.
Suicide in the Phaedo
Authors: Werner Daniel
Published: December 2018

In the Phaedo the character Socrates argues that suicide is morally wrong. This is in fact one of only two places in the entire Platonic corpus where suicide is discussed. It is a brief passage, and a notoriously perplexing one. In this article, I distinguish between two arguments that Socrates gives in support of his claim. I argue that one of them (what I call the Gods Argument) is not to be taken literally, while the other (what I call the Prison Argument) represents the deeper reason for the prohibition of suicide. I further relate the question of suicide to the overarching concerns of the Phaedo as a whole: the nature of our incarnate “imprisonment”, the nature and purpose of philosophy, the philosophical “purification” of the soul, the human pursuit of knowledge, and the nature of the divine.
Beutekunst und Kunstraub
Authors: Grelka Frank
Published: December 2018

Vorspann

Zu den ungelösten Folgeproblemen des deutsch-sowjetischen Kriegs gehört der schwierige Komplex von Beutekunst und Kunstrestitution. Trotz langjähriger Verhandlungen konnten beide Seiten hier zu keiner Übereinkunft finden. Frank Grelka untersucht im vorliegenden Aufsatz Konzepte, Ansprüche und die Durch-führung der sowjetischen Kunstrequisition in Deutschland nach dem Zweiten Weltkrieg und kann zeigen, dass diese über das Prinzip der restitution in kind deutlich hinausgingen.
The Greek Text of Revelation in Late Antique Egypt: Materials, Texts, and Social History
Authors: Malik Peter
Published: December 2018

The Book of Revelation has been something of an outlier within parts of the Christian tradition, as evidenced, among other things, by its peculiar canonical reception. As regards the earliest period of transmission, however, the Greek text of Revelation is relatively well attested. In this vein, the present study seeks to examine the relevant Greek materials from late antique Egypt, and thus elucidate the earliest textual and material transmission of this book. The manuscripts in question will be surveyed with a particular focus on their distinctive features such as book formats and scribal practices, as well as textual characteristics, followed by reflections on their socio-historical significance.
Theorie der Streuung schneller geladener Teilchen I. Einzelstreuung am abgeschirmten Coulomb-Feld
Authors: Moliere Gert
Published: December 2018

Die quantenmechanische Theorie der elastischen Einzelstreuung am abgeschirmten Coulomb - Feld wird unter Berücksichtigung der Abschirmung nach der Thomas - Fermi - Methode in analytischer Form entwickelt. Die Theorie ist gültig für beliebige Werte des Parameters α ≡ zZI( 137 ß) [Z = Ordnungszahl der streuenden Atome, ± z e = Ladung der gestreuten Teilchen, v deren Geschwindigkeit, ß = v/c] sowie für Streuwinkel x 90 ° und für kinetische Energie der Teilchen Ekinz≳zZ4/3 • 100 eV. Der Spineinfluß, der bei kleinen Streuwinkeln gering ist, wurde vernachlässigt, womit die Theorie für alle Sorten geladener Teilchen gilt. Als Ergebnis wurde für das Verhältnis q(χ) ≡ ] Q ( χ ) / <QRuth. (χ) [Q(χ) = diff. Streuquerschnitt pro Raumwinkeleinheit um χ, QRuth. (χ) = Rutherfordscher Streuquerschnitt] ein Integralausdruck gefunden, der bei großen χ in die für alle α gültige asymptotische Formel

übergeht. Die hierbei und im folgenden auftretende Winkelkonstante ist χo = Z1/3 • 2,44 105 eV/(pc) [Winkelgrad] [p = Impuls; pc in Elektron-Volt]. Die asymptotische Formel ist praktisch verwendbar, solange sie g(χ) >0,9 ergibt. Im übrigen Bereich kann der Verlauf der Funktion q (χ) mit Hilfe von Interpolationsformeln der Gestalt χq = χo( Aq+ Bq a2) 1/2 ermittelt werden, wobei χq denjenigen Winkel bedeutet, für den das Verhältnis Q/QRuth. den festen Wert q annimmt. Die Zahlen Aq und Bq sind für eine Reihe von Werten q tabuliert (vergl. S. 143). Der so konstruierte Funktionsverlauf von q (χ) ist exakt für die Grenzfälle kleiner und großer α und stellt für Zwischenwerte von α eine gute Näherung dar, wie der Vergleich mit einigen durch numerische Auswertung erhaltenen Punkten zeigt (vergl. Abb. 2 S. 143). - Der letzte § (9) dient der Vorbereitung der im Tl. II behandelten Theorie der Vielfachstreuung.
Über die thermische Dissoziation des Vakuums Über die thermische Dissoziation des Vakuums
Authors: Houtermans Fritz G. , Hans J. , Jensen D.
Published: December 2018

Wir möchten in dieser Note auf einige Konsequenzen der Positronentheorie hinweisen, bei denen die Notwendigkeit der Erweiterung der Quantentheorie durch die Einführung einer "kleinsten Länge" besonders augenfällig wird. Wie in der Literatur schon mehrfach hervorgehoben wurde 1 , befinden sich in einem "materiefreien" Hohlraum im thermischen Gleichgewicht immer eine Anzahl Elektron-Positron-Paare. Wenn auch bei "normalen Temperaturen" die Zahl solcher Paare sehr gering ist, so steigt sie doch sehr rasch mit der Temperatur an, und bei kT über 137 mc2 (m = Elektronenmasse, c = Lichtgeschwindigkeit) würde schon mehr als ein Paar auf das Elementarvolumen 4 π/3 (e2 /mc2 ) 3 entfallen, so daß sich bei dieser Temperatur ganz zwangsläufig eine "dichteste Packung" von Elementarteilchen ergeben würde (wegen Lorentz-Kontraktion s. 2.). Temperaturen dieser Größenordnung sind schon mehr-fach im Zusammenhang mit kosmologischen Fragen und der Elementen-Häufigkeits-Ver-teilung diskutiert worden; jedoch scheint uns nach dem eben Gesagten die Behandlung dieses Fragenkomplexes ohne direkte Bezugnahme auf das Problem der Elementar-teilchen nicht sinnvoll zu sein. Als weitere Konsequenz der thermischen Dissoziation besitzt das Vakuum eine tem-peraturabhängige Polarisierbarkeit, im Unterschied zu den Voraussetzungen 2 der Dirac-Heisenbergschen Positronentheorie, die sich auf den Fall T = 0 bezieht. Es ergeben sich also Zusatzglieder zur He i senberg-Eulerschen 3 Lagrange-Funktion des elektromagnetischen Feldes, die bereits bei kT = mc2 merklich werden. Eine Coulomb sehe Ladung, etwa ein Atomkern, umgibt sich mit einer Dipolwolke, die freilich bei normalen Temperaturen äußerst schwach und ausgedehnt ist, aber bei kT über mc2 das Coulomb-Feld wesentlich modifiziert.
Zur Deutung der Regelmäßigkeiten in den Spektren substituierter Benzole
Authors: Förster Theodor
Published: December 2018

Einige empirisch lange bekannte Regelmäßigkeiten in den Frequenzen und Intensitäten der ultravioletten Absorptionsspektren substituierter Benzole werden mit Hilfe der quantenmechanischen Valenztheorie gedeutet.
Über den Ablauf zusammengesetzter chemischer Reaktionen Systeme von Reaktionen I. Ordnung
Authors: Jost Wilhelm
Published: December 2018

1. Es kann gezeigt werden, daß in beliebig kompliziert zusammengesetzten chemischen Umwandlungen nach der I. Ordnung keine Periodizität auftreten kann, sofern das Prin-zip der mikroskopischen Reversibilität erfüllt ist.

2. Darüber hinaus gilt die schärfere Aussage: die Konzentration jeder Komponente dieses Systems kann als Funktion der Zeit höchstens (n-2) Extrema durchlaufen, wenn n die Zahl der Komponenten ist. I. E s ist bekannt, daß man bei der Berechnung der
Zur Breit-Wigner-Formel II
Authors: Flügge Siegfried
Published: December 2018

In Fortsetzung einer früheren Arbeit wird die Breit-Wigner-Formel auf den Fall mehrerer Resonanzniveaus erweitert und gezeigt, daß dabei charakteristische Inter-ferenzerscheinungen zwischen den einzelnen Niveaus auftreten, die der experimentellen Erfassung zugänglich sind. Insbesondere wird der Fall eines engen Dubletts diskutiert und gezeigt, daß hierbei durch Interferenzerscheinungen eine sehr schmale und hohe Linie an Stelle zweier normaler zustande kommen kann.
In Vitro Assessment of Synthetic Nano Engineered Graft Designed for Further Clinical Study in Nerve Regeneration
Authors: Sadeghi Ali , Moztarzadeh Fatholah , Aghazadeh Mohandesi Jamshid , Grothe Claudia , Talini Kirsten Haastert , Zalli Ali Reza , Jalili Khoshnoud Reza
Published: December 2018

Background: Electrospun nanofibrous scaffolds are considered as promising candidates in neural tissue regeneration due to their ability to support neural cell attachment, spreading and proliferation. Methods: In this paper, various type of nanofibers scaffold based on polycaprolactone) (PCL) were fabricated using electrospinning. The main drawback of PCL scaffolds is their low bioactivity of scaffold surface. To overcome this surface and composition modification was used to enhanced hydrophilicity and bioactivity of scaffold. Results: The scanning electron microscopy (SEM) results indicate that fiber diameter entirely depends on the solvent system and added component of gelatin and chitosan which by adding gelatin and chitosan fiber diameter decreased. In vitro studies using PC12 cells revealed that the plasma surface modified and blended scaffold with chitosan and gelatin nanofibrous scaffold supports cell attachment, spreading and indicate a significant increase in proliferation of PC12 in the presence of chitosan. The results demonstrated that gelatin and chitosan caused a significant enhancement in the bioactivity of the scaffold, which confirmed by MTT assay and improved the cell spreading and proliferation of neural cell on the scaffolds. Conclusion: Based on the experimental results, the PCL/chitosan/PPy conductive substrate could be used as a potential scaffold for clinical research in the field of neural regeneration and healing.
Comparison of Oral versus Intravenous Proton Pump Inhibitors in Preventing Re-bleeding from Peptic Ulcer after Successful Endoscopic Therapy
Authors: Valizadeh Toosi Seyed Mohammad , Elahi Vahed Ahmad Reza , Maleki Iradj , Bari Zohreh
Published: December 2018

BACKGROUND Proton pump inhibitors (PPIs) are now widely prescribed for the management of patients with acute upper gastrointestinal bleeding; although its optimal dose and route of administration has remained a controversial issue. The aim of this study was to assess the clinical effectiveness of high dose oral versus intravenous (IV) PPI after successful endoscopic therapy in patients with bleeding peptic ulcer disease. METHODS 178 patients with active upper gastrointestinal bleeding due to a peptic ulcer with stigmata of high risk for re-bleeding entered the study. After successful endoscopic hemostasis, they were randomized to receive either high dose oral pantoprazole (80 mg stat and 80 mg twice daily for 3 days) or high dose intravenous pantoprazole (80 mg IV infusion within 30 minutes and 8 mg per hour for 3 days). After the 3rd day, the patients in both groups received oral pantoprazole 40 mg twice daily for one month. The end points were comparing the rate of re-bleeding or mortality, and the need for blood transfusion or surgery during the first month between the two groups. RESULTS There were not significant statistical differences between the two groups in the volume of blood transfusion, mean duration of hospital stay, need to surgery, or mortality rates. However, the rates of re-bleeding were 2.3% (2:88) in the IV group and 3.3% (3:90) in the oral group (p = 0.6). CONCLUSION According to our findings, it seems that high dose oral PPI can be a good alternative to high dose IV PPI in patients with bleeding peptic ulcer who are at high risk of re-bleeding. Due to the lower cost and the availability of oral PPIs, their use can be economically much more affordable.
An Efficient Population Density Method for Modeling Neural Networks with Synaptic Dynamics Manifesting Finite Relaxation Time and Short-Term Plasticity
Authors: Huang Chih-Hsu , Lin Chou-Ching K.
Published: December 2018

When incorporating more realistic synaptic dynamics, the computational efficiency of population density methods (PDMs) declines sharply due to the increase in the dimension of master equations. To avoid such a decline, we develop an efficient PDM, termed colored-synapse PDM (csPDM), in which the dimension of the master equations does not depend on the number of synapse-associated state variables in the underlying network model. Our goal is to allow the PDM to incorporate realistic synaptic dynamics that possesses not only finite relaxation time but also short-term plasticity (STP). The model equations of csPDM are derived based on the diffusion approximation on synaptic dynamics and probability density function methods for Langevin equations with colored noise. Numerical examples, given by simulations of the population dynamics of uncoupled exponential integrate-and-fire (EIF) neurons, show good agreement between the results of csPDM and Monte Carlo simulations (MCSs). Compared to the original full-dimensional PDM (fdPDM), the csPDM reveals more excellent computational efficiency because of the lower dimension of the master equations. In addition, it permits network dynamics to possess the short-term plastic characteristics inherited from plastic synapses. The novel csPDM has potential applicability to any spiking neuron models because of no assumptions on neuronal dynamics, and, more importantly, this is the first report of PDM to successfully encompass short-term facilitation/depression properties.
Coordination between Prefrontal Cortex Clock Gene Expression and Corticosterone Contributes to Enhanced Conditioned Fear Extinction Recall
Authors: Woodruff Elizabeth R. , Chun Lauren E. , Hinds Laura R. , Varra Nicholas M. , Tirado Daniel , Morton Sarah J. , McClung Colleen A. , Spencer Robert L.
Published: December 2018

Post-traumatic stress disorder (PTSD) is associated with impaired conditioned fear extinction learning, a ventromedial prefrontal cortex (vmPFC)-dependent process. PTSD is also associated with dysregulation of vmPFC, circadian, and glucocorticoid hormone function. Rats have rhythmic clock gene expression in the vmPFC that requires appropriate diurnal circulatory patterns of corticosterone (CORT), suggesting the presence of CORT-entrained intrinsic circadian clock function within the PFC. We examined the role of vmPFC clock gene expression and its interaction with CORT profiles in regulation of auditory conditioned fear extinction learning. Extinction learning and recall were examined in male rats trained and tested either in the night (active phase) or in the day (inactive phase). Using a viral vector strategy,Per1andPer2clock gene expression were selectively knocked down within the vmPFC. Circulating CORT profiles were manipulated via adrenalectomy (ADX) ± diurnal and acute CORT replacement. Rats trained and tested during the night exhibited superior conditioned fear extinction recall that was absent in rats that had knock-down of vmPFC clock gene expression. Similarly, the superior nighttime extinction recall was absent in ADX rats, but restored in ADX rats given a combination of a diurnal pattern of CORT and acute elevation of CORT during the postextinction training consolidation period. Thus, conditioned fear extinction learning is regulated in a diurnal fashion that requires normal vmPFC clock gene expression and a combination of circadian and training-associated CORT. Strategic manipulation of these factors may enhance the therapeutic outcome of conditioned fear extinction related treatments in the clinical setting.
Origin, Composition, and Structure of the Supernumerary B Chromosome of Drosophila melanogaster
Authors: Hanlon Stacey L , Miller Danny E , Eche Salam , Hawley R Scott
Published: December 2018

In addition to a defined number of essential chromosomes, extra chromosomes called “B chromosomes” are present in roughly 15% of eukaryotic species. In this study, Hanlon et al. analyzed the recently discovered Drosophila melanogaster...

The number of chromosomes carried by an individual species is one of its defining characteristics. Some species, however, can also carry supernumerary chromosomes referred to as B chromosomes. B chromosomes were recently identified in a laboratory stock of Drosophila melanogaster—an established model organism with a wealth of genetic and genomic resources—enabling us to subject them to extensive molecular analysis. We isolated the B chromosomes by pulsed-field gel electrophoresis and determined their composition through next-generation sequencing. Although these B chromosomes carry no known euchromatic sequence, they are rich in transposable elements and long arrays of short nucleotide repeats, the most abundant being the uncharacterized AAGAT satellite repeat. Fluorescent in situ hybridization on metaphase chromosome spreads revealed this repeat is located on chromosome 4, strongly suggesting the origin of the B chromosomes is chromosome 4. Cytological and quantitative comparisons of signal intensity between chromosome 4 and the B chromosomes supports the hypothesis that the structure of the B chromosome is an isochromosome. We also report the identification of a new B chromosome variant in a related laboratory stock. This B chromosome has a similar repeat signature as the original but is smaller and much less prevalent. We examined additional stocks with similar genotypes and did not find B chromosomes, but did find these stocks lacked the AAGAT satellite repeat. Our molecular characterization of D. melanogaster B chromosomes is the first step toward understanding how supernumerary chromosomes arise from essential chromosomes and what may be necessary for their stable inheritance.
Metodología para la formulación de proyectos de carrera en el sistema de educación superior. Experiencia de aplicación
Authors: Rodríguez-Cisneros Luz Marina , Reascos-Trujillo Amparo Del Carmen , Andrade-Cadena José Valdemar
Published: December 2018

Este artículo tiene como objetivo la presentación de una propuesta metodológica para la construcción de proyectos de grado en el sistema de educación superior que integra aspectos normativos del Ecuador y elementos conceptuales que consideran nuevos paradigmas del conocimiento. La metodología utilizada consistió en investigación-acción participativa que inició con la indagación exploratoria y diálogo académico liderado por un equipo de investigación que permitió establecer la relación de los elementos que integran los proyectos de carrera con el uso de la hermenéutica como método y el análisis de contenido como técnica para la revisión de los documentos legales y conceptuales publicados por el Consejo de Educación Superior (CES) ecuatoriano. La siguiente fase consistió en un proceso de orientación y acompañamiento a los equipos de trabajo, mientras que en la fase final el resultado fue la generación de esta propuesta metodológica y la presentación de los proyectos de rediseño de las carreras de Agropecuaria y Comunicación de la Pontificia Universidad Católica del Ecuador - Sede Ibarra (PUCE-SI), los cuales fueron aprobados y se encuentran ofertados actualmente, por lo que la metodología se considera como validada de forma satisfactoria. Este trabajo es de gran utilidad para los departamentos académicos de instituciones de educación superior, pues en función de elementos legales y conceptuales formula orientaciones pragmáticas en la identificación de aspectos claves que permitan la construcción y articulación del currículo de proyectos de carrera.
¿Tienes razón evaluación? Notas para la profundización de una noción filosófica de la educación
Authors: Giuliano Facundo
Published: December 2018

El presente ensayo parte de una pregunta que se propone buscar una profundización crítica en torno de la indagación de un tipo de racionalidad que habita la educación moderna y que en nuestra investigación hemos optado por llamar razón evaluadora. La reflexión deleuziana sobre las sociedades de control, subsidiaria de la noción de sociedades disciplinarias de Foucault, será un punto de referencia fagocitado para introducirnos en la cuestión de este tipo de racionalidad que, como aquí analizamos, aloja también características del llamado poder pastoral en íntima relación con las configuraciones contemporáneas del capitalismo. Se ofrecerá una definición provisoria de esta para luego, a la luz de los análisis propios que involucran nociones como las de disciplina, tecnologías de gobierno, normalización y biopolítica –que aquí repensaremos–, avanzar en una mirada más compleja que relacione lo ético, lo político, lo social y lo económico con lo filosófico-educativo de nuestro planteo como modo de aproximarnos al nexo que esta racionalidad esboza entre la educación y las actuales sociedades de control. De este modo, la razón evaluadora se abrirá como un problema ético-político que es fundamental atender, ya que: a) se ha configurado históricamente de modo tal que atraviesa y fundamenta prácticas, tecnologías y dispositivos; b) con vigilancias cada vez más sutiles y sanciones cada vez más justificadas en su afán “pedagógico”, se erige entre el monitoreo y el cálculo que reducen toda potencia de alteridad; c) posee una dimensión racista cuya versatilidad le permite moverse entre la normalización y la normación; d) coadyuva a multiplicar el modelo de mercado fijando procedimientos que ponen al sujeto como empresario de sí. Finalmente, los trazos de este análisis esperan constituirse en pistas para elucidar nuevas formas de resistencia y re-existencia contra la compulsión evaluativa contemporánea.
La autoconfianza matemática de estudiantes de educación secundaria: Un estudio en Costa Rica
Authors: Meza-Cascante Luis Gerardo , Agüero-Calvo Evelyn , Suárez-Valdés-Ayala Zuleyka
Published: December 2018

e estudia la “autoconfianza matemática” del estudiantado de la educación media costarricense utilizando la subescala de autoconfianza de Fennema y Sherman (1976) y se analiza la existencia de diferencias en esta variable por sexo, por nivel educativo y zona geográfica de ubicación del colegio. Las personas participantes en el estudio fueron 2984 estudiantes (51% femenino) de sétimo a undécimo año de colegios públicos diurnos oficiales del Ministerio de Educación Pública de Costa Rica. Los colegios participantes fueron seleccionados por muestreo simple aleatorio estratificado y por conglomerados, según la zona de ubicación (69.5% urbano), y según la población por provincia (19.5% Alajuela; 12.5% Cartago; 9.3% Guanacaste; 10.6% Heredia; 10.3% Limón; 9.4% Puntarenas; 28.4% San José). El estudiantado seleccionado para el estudio en cada colegio muestreado pertenece al grupo número dos de cada nivel educativo (18.9% sétimo; 20.5% octavo; 21.4% noveno; 19% décimo; 20.2% undécimo). Los resultados sugieren que, en forma conjunta, cerca de un 78.9% del estudiantado muestra niveles de autoconfianza entre alto y moderado. También indican la existencia de diferencias en el nivel de autoconfianza matemática según el sexo, con niveles menores para las mujeres, con una magnitud de las diferencias mediana. Los hallazgos además plantean que no hay diferencias en el nivel de autoconfianza matemática entre estudiantes de décimo y undécimo entre sí, mas si con el nivel de noveno; este último es el que alcanza mayores índices de autoconfianza matemática de los tres. El estudio no detectó diferencias en el nivel de autoconfianza matemática entre estudiantes según la zona de ubicación del colegio. Los resultados sugieren, al menos, las siguientes líneas de investigación: profundizar en las causales de las diferencias detectadas en el nivel de autoconfianza matemática por sexo y de las que puedan explicar por qué disminuye el nivel de autoconfianza matemática en el estudiantado de la “Educación Diversificada”.
Characterization of Autonomous Work in a Chilean English Pedagogy Program: Teachers’ and Freshmen’s Perspectives
Authors: Correa-Pérez Roxanna , Sanhueza-Jara María Gabriela
Published: December 2018

Autonomy in language learning is recognized as a basic skill language learners need to develop. This study describes the autonomous work activities university students carry out in a first-semester course of an English teaching program, and the amount of time they invest in each of these activities. Moreover, it describes the teachers’ perspective on students’ autonomous work. It is a descriptive  mixed study with an exploratory scope. The study considers data generated through the application of a questionnaire and an in-depth interview to 48 freshmen from an English Pedagogy Program,  as well as a questionnaire and a focus group applied to eight English teachers from the same program. The qualitative data were analyzed through content analysis method; and the quantitative data, through a frequency method of analysis. The analysis reveals that there is an imbalance between the time teachers estimate students devote to autonomous work and the real time students declare to invest in it. In relation to students autonomous work activities, it can be concluded that they concentrate on activities which are less stressful and the ones they do not need to interact with teachers. This study provides empiric information that could be useful to design courses that consider autonomous work.
A Seuso-tál állatábrázolásai
Authors: Vörös István
Published: December 2018

A tanulmány a Seuso-tál szegélydíszítésének 12 szelvényében és a központi medalion három sávjában ábrázolt állatok és vadászjelenetek archaeozoológiai leírását adja. A tálon 136 figura: 39 személy, 21 kutya, 75 egyéb állat és egy kocsi ábrázolása található. Néhány állat korábbi meghatározását revideálni kellett.
A szegvár-sápoldali 7. századi sírcsoport gyöngyleletei
Authors: Pásztor Adrien
Published: December 2018

A tanulmány a szegvár-sápoldali sírcsoport öt sírjának egymástól eltérő stílusú gyöngyviseletét mutatja be. Az adatbázisba felvett és rendszerezett 32 db gyöngy tipokronológiai elemzése és az egymástól eltérő technológiával készült gyöngysorok ismertetése egy 7. század közepe táján megfigyelhető gyöngyviselet divat- és korszakváltásának néhány jellegzetességére világít rá.
A szegvár-sápoldali 1. sír keleti kapcsolatai az újabb orosz és ukrán kutatás fényében
Authors: Gulyás Bence
Published: December 2018

Bóna István a szegvár-sápoldali 1. sírt az avarság első generációjához sorolta. Ennek megfelelően a temetkezési szokások és a mellékletek keleti párhuzamait keleten, főleg Közép- és Belső-Ázsiában kereste. Ugyanakkor az új eredmények fényében a sápoldali halott kulturális gyökerei Kelet- Európában, a Sivašovka-típusú temetkezések előzményei között keresendők. A sírban talált tárgyak kapcsolatai nem ázsiai, sokkal inkább közép-kelet-európai kontextusban értelmezhetők.
A tatárjárás régészetének újabb távlatai két kiskunsági lelőhely eredményeinek fényében
Authors: Rosta Szabolcs
Published: December 2018

A tanulmány két kiskunsági lelőhely tanulságai alapján a tatárjárás kérdéskörét taglalja. A kiskunmajsai és a Bugac közelében lévő Árpád-kori kolostort övező településen feltárt tömeggyilkosságok bizonyítékai kapcsán a korabeli források adatainak hitelességét vizsgálja.
Érem- és kincslelet Kiskunmajsa-Jonathermál lelőhelyen
Authors: V. Székely György , Balázs Nagy
Published: December 2018

2016-ban Kiskunmajsán egy régészeti leletmentés során egy éremlelet, valamint egy kincslelet került elő. A két leletegyüttes pénzeinek meghatározását V. Székely György végezte el. Jelen tanulmányunk célja a numizmatikai emlékanyag rövid ismertetése, amivel a feltáráson előkerült régészeti jelenségek keltezéséhez kívánunk hozzájárulni.
Controlling in Hungarian hospitals: History and key issues
Authors: Krenyácz Éva
Published: December 2018

The aim of this review paper is to illustrate the areas of interest and the thinking of Hungarian hospital managers by providing a summary of the relevant Hungarian health care controlling literature and to give an introduction of potential research directions. The paper summarizes the “public discourse” and thinking on controlling, and simultaneously highlights the priorities of health care as well. The main range of interest are the financing problems and their solutions, as well as other kind of uncertainty arising from the continuous changes in roles and measures. In the early ninties some health care institutions started to apply controlling systems as a result of the introduction of performance-based financing and often published articles about it up to 2004. In 2015, a project created to enhance the operational efficiency of the health care system restarted controlling thinking: unified management measures required for hospitals may induce the development of the controlling data service, more accurate reporting, management attention, and experience sharing.
‘Does the picture below show a heterosexual couple or not?’
Authors: Moita-Lopes Luiz Paulo , Fabrício Branca Falabella
Published: December 2018

In this paper we investigate an intimate encounter in 'Life in the Closet', a blog fed by a Brazilian undergraduate, N.B., between 2011 and 2014. As a case in point, we focus on how a YouTube video advert called 'The Man Man' is successively entextualised in the blog, by following its re-entextualisation into posts made by the blogger himself and other participants. We explore this digital event as an instance of several chained reperformances, observing the highly reflexive activity that goes on in the blog and how such reflexivity operates through the friction of sedimented and transgressive discourses. By using a performative and scalesensitive approach to textuality and subjectivities, we fathom how participants reflexively queer gender, sexuality, age, race and social class by intersectionally making each one of these 'categories' dissolve its solidified meaning in the light of the Other as these meanings are called into being.
Analysis of Compression Techniques for Stereoscopic Images
Authors: Vasiljevic Ivana , Dragan Dinu , Obradovic Ratko , Petrović Veljko
Published: December 2018

Virtual Reality (VR) and Augmented Reality (AR) Head-Mounted Displays (HMDs) have been emerging in the last years and they are gaining an increased popularity in many industries. HMDs are generally used in entertainment, social interaction, education, but their use for work is also increasing in domains such as medicine, modeling and simulation. Despite the recent release of many types of HMDs, two major problems are hindering their widespread adoption in the mainstream market: the extremely high costs and the user experience issues [1]. The illusion of a 3D display in HMDs is achieved with a technique called stereoscopy. Applications of stereoscopic imagining are such that data transfer rates and—in mobile applications—storage quickly become a bottleneck. Therefore, efficient image compression techniques are required. Standard image compression techniques are not suitable for stereoscopic images due to the discrete differences that occur between the compressed and uncompressed images. The issue is that the loss in lossy image compression may blur the minute differences between the left-eye and right-eye images that are crucial in establishing the illusion of 3D perception. However, in order to achieve more efficient coding, there are various coding techniques that can be adapted to stereoscopic images. Stereo image compression techniques that can be found in the literature utilize discrete Wavelet transformation and the morphological compression algorithm applied to the transform coefficients. This paper provides an overview and comparison of available techniques for the compression of stereoscopic images, as there is still no technique that is accepted as best for all criteria. We want to test the techniques with users who would actually be potential users of HMDs and therefore would be exposed to these techniques. Also, we focused our research on low-priced, consumer grade HMDs which should be available for larger population.
ЕФЕКТИВНІСТЬ ЗАСТОСУВАННЯ ВИСОКОБІЛКОВИХ ФУНКЦІОНАЛЬНИХ ПРОДУКТІВ У ВИРОБНИЦТВІ БУЛОЧОК
Authors: ЛАКІЗА О. В. , МАСЛІКОВА К. П. , ІЩЕНКО М. В.
Published: December 2018

Хлібобулочні вироби є важливим продуктом харчування для більшості населення України. Потреба в хлібобулоч-них виробах притаманна людям будь-якого віку, соціального статусу і рівня доходів. Хлібопекарська галузь покликана забезпечувати споживачів країни цими життєво значущими продуктами харчування в необхідних обсягах, асортименті таякості. В даний час в світі велика увага приділяється збагаченню хлібобулочних виробів різними корисними речовинами, що додають їм лікувальні та профілактичні властивості. Лікувальний і профілактичний ефект від вживання дієтичних хлібобулочних виробів забезпечується або введенням в рецептуру необхідних додаткових компонентів, або вилученням небажаних, або зміною технології їх приготування. Однією з ключових умов сучасного виробництва функціональних хлібобулочних виробів є пошук і використання нових компонентів рецептурного складу. Функціональні продукти - це харчові продукти, що є частиною звичайного раціону, які крім поживних властивостей мають здатність позитивно впливати на тічи інші функції організму людини. У статті розглянуто сучасні напрями розширення асортименту хлібобулочних виробів з оздоровчими властивос-тями. З метою урізноманітнення продукції хлібопекарського виробництва функціонального призначення було запропоновано введення в рецептуру булочок високобілкових функціональних продуктів, а саме льняного шроту та шроту з насіння гарбуза. Відомо, що насіння льону та гарбуза містить у своєму складі всі ессенціальні амінокислоти. На основі експериментальних досліджень розроблено рецептури булочок з додаванням лляного і гарбузового шроту, які дають змогу одержати збагачені білком булочки відповідної якості. Проведено органолептичну оцінку якості булочок з різним вмістом шротів, побудовано профілограми на основі бальної оцінки. Зроблено висновок стосовно впливу концентрації шротів на пористість та вологість готових виробів. Обрано оптимальну концентрацію льняного шроту ташроту з насіння гарбуза в рецептурі булочок.
РОЗРОБКА БІСКВІТНИХ НАПІВФАБРИКАТІВ ДІЄТИЧНОГО ПРИЗНАЧЕННЯ
Authors: ЛАКІЗА О.В. , ЩЕРБИНА М.В. , ІЩЕНКО К.Ю.
Published: December 2018

Кондитерські вироби користуються широким попитом у дорослого населення та дітей. Однак, наявність високого вмісту цукру в рецептурі кондитерських виробів не дозволяє людям хворим на діабет та ожиріння вживати їх в їжу. Особам з такими захворюваннями потрібно дотримуватись дієти, яка передбачає обмежене споживання цукру в раціоні харчування. На жаль, кондитерські вироби дієтичного, лікувально-профілактичного, спеціального призначення для різних груп населення виготовляються в недостатній кількості і їх частка в загальному об'ємі виробництва не перевищує 1-2 % В даний час в світі велика увага приділяється створенню кондитерських виробів лікувального та дієтичного спрямування. Лікувальний і профілактичний ефект від вживання дієтичних кондитерських виробів забезпечується або введенням в рецептуру необхідних додаткових компонентів, або вилученням небажаних, або зміною технології їх виготовлення. Однією з ключових умов сучасного виробництва дієтичних кондитерських виробів є пошук і використання нових компо- нентів рецептурного складу. Дієтичні продукти харчування – це ті продукти, які є корисними та не навантажують травну систему, печінку і нирки й не містять шкідливих речовин і компонентів. У статті розглянуто сучасні напрями розширення асортименту кондитерських виробів з дієтичними властивостями. З метою урізноманітнення продукції кондитерського виробництва дієтичного призначення було запропоновано введення в рецептуру бісквітів природних цукрозамінників : екстракт стевії, тростинний цукор. Дані цукрозамінники мають низький глікемічний індекс у порівнянні з традиційним буряковим цукром. На основі експериментальних досліджень розроблено рецептури бісквітів з додаванням тростинного цукру та екстракту стевії, які дають змогу одержати дієтичні бісквіти відповідної якості. Проведено органолептичну оцінку яко- сті бісквітів з різним вмістом цукрозамінників, побудовано профілограми на основі бальної оцінки. Зроблено висновок стосовно впливу цукрозамінників на кінетику піноутворення і стійкість піни. Обрано оптимальну концентрацію тростинного цукру та екстракту стевії в рецептурі бісквітних напівфабрикатів.
ТОЧНАЯ АГРОТЕХНОЛОГИЯ БУДУЩЕГО НАЧИНАЕТСЯ СЕГОДНЯ
Authors: ФАДЕЕВ Л.В.
Published: December 2018

Динамика прогресса в агробизнесе позволяет утверждать, что в первой половине XXI века точная агротехнология станет абсолютной нормой на всех континентах по той простой причине, что она позво- ляет повысить эффективность использования земли. Точная агротехнология – это точное земледелие, равнораспределенное размещение растений на поле и точный высев сильных семян, обеспечивающих количество растений перед уборкой, практически равное количеству высеянных семян, т.е. точная норма высева сильных семян в шт. кг/га.
A clinical case of hybrid surgical treatment of aortic arch saccular aneurysm in a patient with newly diagnosed aortic coarctation
Authors: Chernyavsky M. A. , Zherdev N. N. , Chernova D. V. , Chernov A. V. , Kudaev Yu. A. , Gusev A. A.
Published: December 2018

.
Results of endovascular correction of atrial septal defect and early heart remodeling in children of preschool and school age
Authors: Tarasov R. S. , Shushpannikov P. A. , Ganyukov V. I. , Sizova I. N.
Published: December 2018

Aim. To analyze the results and features of early cardiac remodeling (CR) in children of preschool and school age after endovascular correction of atrial septal defect (ASD).

Material and methods. A prospective study included 27 children with secondary ASD who underwent endovascular correction for one year (from the beginning of 2017 to the beginning of 2018). The patients were divided into two groups. The first (n=12) — children of preschool age (<8 years old), mean age 4,5 [3;6], and the second (n=15) — school age (8­18 years old), mean age 12 [9;14]. The following indicants were assessed during hospitalization: the success of the intervention, hospital complications, functional data characterizing CR according to echocardiography before and after the correction of the defect.

Results. It was shown that all children successfully completed endovascular closure of ASD. Complications were not identified. We find several statistically significant changes in echocardiogram data before and after the intervention. In the preschool age group, the size of the right ventricle (RV) decreased from 1,66 to 1,45 cm (p=0,028), the right atrium (RA) decreased from 3,58 to 3,1 cm (p=0,003), and the longitudinal size of RV decreased from 3 to 2 cm (p=0,032) and basal size of RV — from 5,98 to 4,4 cm (p=0,005), the volume of RA decreased from 25,7 to 20,7 ml (p=0,005). In the group of school age, the size of the RV changed from 2,08 to 1,8 cm (p=0,038), the size of the RA — from 3,72 to 2,71 cm (p=0,007), the RV area in diastole — from 12,4 to 10,6 mm2. The gradient has changed from 2 to 1,54 mm Hg (p=0,043), the frontal size of the tricuspid valve (TV) decreased from 2,7 to 2,48 cm (p=0,010). The basal size of RV decreased from 3 to 2,6 cm (p=0,015), the median size — from 2,73 to 2,37 cm (p=0,017) and the longitudinal size — from 5,97 to 5,45 cm (p=0,007). No significant differences in CR among the groups were found.

Conclusion. We made conclusion about the efficacy and safety of endovascular correction of ASD, which has a positive effect on early HR in children, both in early and in old age.
Surgical aspects and results of a single-center prospective register of transcatheter aortic valve implantation
Authors: Prokhorikhin A. A. , Tarkova A. A. , Zubarev D. D. , Fartakov E. I. , Malaev D. U. , Boykov A. A. , Kamenskaya O. V. , Kretov E. I.
Published: December 2018

Aim. To assess the results of transcatheter aortic valve implantation (TAVI) in patients with symptomatic aortic valve stenosis in routine clinical practice.

Material and methods. From 2015 to 2018 based on the Meshalkin National Medical Research Center in the prospective register of patients undergoing TAVI, 191 patients were included. The patients were divided into low surgical risk group (EuroSCORE II <4%) — 137 patients, and increased surgical risk group (EuroSCORE II >4%) — 54 patients. We defined incidence of serious adverse cardiovascular events (all­cause death, non­fatal myocardial infarction and non­fatal stroke/ transient ischemic attack (TIA)), as well as the incidence of permanent pacemaker implantation (PPI).

Results. In the postoperative period, cardiac death was observed in 3 (2,2%) and 2 (3,7%) cases in the low­risk and high­risk groups, non­fatal stroke/TIA — in 7 (5,1%) and 2 (3,7%) cases. The frequency of the composite endpoint was 10 (7,3%) and 4 (7,4%), respectively (p>0,999). During the hospitalization non­fatal myocardial infarction cases in the groups were not registered. The incidence of PPI due to the complete atrioventricular block was 10,9% and 13%, respectively.

Conclusion. This prospective register demonstrates good results of TAVI in patients with different surgical risk. Relative frequency of lethality, non­fatal myocardial infarction, non­fatal stroke/TIA and PPI did not differ significantly in the low and high surgical risk groups.