bluuebunny/crossref_metadata_2025 huggingface dataset:
„Zajęcia z edukacji seksualnej nie istnieją. Istnieją lekcje WDŻ-u”. Polska edukacja seksualna z perspektywy młodych dorosłych
Authors: Jeznach Alicja
Published: March 2023

Artykuł jest próbą przybliżenia stanowiska młodych dorosłych wobec polskiej edukacji seksualnej, która – pomimo europejskich zaleceń – wciąż pozostaje na niezadowalającym poziomie. Dane zebrano w celu zobrazowania stosunku młodych dorosłych do oferowanej im niegdyś edukacji seksualnej, jak i ukazania związanych z nią doświadczeń. Wyniki badania przeprowadzonego przez autorkę artykułu sugerują, iż postulowane przez respondentów źródła edukacji seksualnej nie pokrywają się z tymi, z których faktycznie czerpali wiedzę. W związku z tym postanowiono przyjrzeć się edukacji seksualnej prowadzonej (bądź nie) w polskich szkołach i domach. Uzyskane rezultaty mogą stanowić cenną wiedzę dla osób lub organizacji zajmujących się tą problematyką. Poruszone w artykule kwestie mogą wyznaczyć kierunki dalszych badań, które pozwolą lepiej zrozumieć istotę problemów związanych z edukacją seksualną i wdrożyć odpowiednie działania mające na celu jej poprawienie w Polsce.
Los órganos de tratados de las Naciones Unidas como alternativa limitada para la salvaguarda de los derechos humanos en España
Authors: Martínez Pérez Enrique J.
Published: March 2023

La presente contribución tiene como objeto examinar la naturaleza jurídica de los pronunciamientos de los órganos de expertos de tratados de carácter universal de derechos humanos desde una perspectiva interna e internacional, con especial atención a los cauces procesales a los que se puede recurrir en España para dar efecto jurídico a sus decisiones.
Fabrication Methods of the Polygonal Masonry of Large Tightly-fitted Stone Blocks with Curved Surface Interfaces in Megalithic Structures of Peru
Authors: Lapshin Rostislav
Published: March 2023

The article suggests methods that allow creating the most complicated type of polygonal masonry found in Peru. This masonry type consists of large stone blocks weighing from several hundred kilograms to several tons fitted close to each other almost without a gap between complicated curved surfaces over a large area. The work provides a description of techniques, which apparently were used by builders who arrived from Europe. The techniques under discussion are based on the use of a reduced clay model, 3D-pantograph, topography translator and replicas. The use of the topography translator, reduced clay model and pantograph provides not only the unique appearance and high quality of masonry of large blocks, but also allows to increase the productivity of the builders significantly. As machines coping-scaling three-dimensional objects are known since the beginning of the 18th century, the stone structures under consideration should be approximately dated by this time. The remaining simpler types of polygonal masonry, when the stones are small or the fitted surfaces are almost flat, or the stones contact each other over a small area, or there are significant gaps between the stones, are quite consistent with the well-known methods of stone processing at that time or earlier, and, therefore, they do not require any additional explanations. The Fortress Sacsayhuaman is considered as an example of early star fortresses that has survived to our time. The polygonal structures in Peru, the polygonal Face Towers and polygonal bas-reliefs in Cambodia, symmetrical statues of pharaohs in Egypt are based on the same construction technologies, working methods, tools and technical contrivances. Therefore, with a high probability one can state that all these monuments were created by the same group of architects, sculptors, builders, and could not have appeared before the 17th century.
Surface Features of As-built Metal Additive AlSi7Mg0.6
Authors: Buchenau Theresa , Thompson Adam , Bruening Hauke , Amkreutz Marc , Mayer Bernd , Piano Samanta
Published: March 2023

Additive manufacturing (AM) technologies show potential for the development of functionally integrated lightweight designs, biomimetic structures and material savings. Typically, as-built surfaces show powder particle agglomerations and re-entrant features, leading to rough surfaces, which are associated with poor fatigue performance. To benefit from the full range of advantages with special focus on aerospace applications, critical features for crack initiation when subjected to fatigue loading need to be identified and mitigated. A first step toward achieving this goal is the surface texture characterisation based on the quantification of surface features. In this paper, selected areal height, functional and feature parameters from ISO 25178-2:2022 are generated and process-specific features are examined for as-built AlSi7Mg0.6 from laser powder bed fusion (PBF-LB). A connection with the particle size distribution of the used powder is demonstrated. It is shown that surface feature analysis opens up opportunities to use physically meaningful surface characteristics in future quality assurance and part qualification processes.
Best Practice Data Sharing Guidelines for Wind Turbine Fault Detection Model Evaluation
Authors: Barber Sarah , Aizpitarte Unai Izagirre , Serradilla Oscar , Alberdi Jon Olaizola , Zugasti Uriguen Ekhi , Aizpurua Jose , Milani Ali Eftekhari , Sehnke Frank , Sakagami Yoshiaki , Henderson Charles
Published: March 2023

The digital era offers many opportunities to the wind energy industry and research community. Digitalisation is one of the key drivers for reducing costs and risks over the whole wind energy project life cycle. One of the largest challenges in successfully implementing digitalisation is the lack of data sharing and collaboration between organisations in the sector. In order to overcome this challenge, a new collaboration method called WeDoWind was developed in recent work. The main innovation of this method is the way it creates tangible incentives to motivate and empower different types of people from all over the world to actually share data and knowledge in practice. In this present paper, the challenges related to comparing and evaluating different SCADA data based wind turbine fault detection models are investigated by carrying out a new case study, the "WinJi Gearbox Fault Detection Challenge", based on the WeDoWind Method. Six new solutions were submitted to the challenge, and a comparison and evaluation of the results show that, in general, some of the approaches (Particle Swarm Optimisation algorithm for constructing health indicators, performance monitoring using Deep Neural Networks, Combined Ward Hierarchical Clustering and Novelty Detection with Local Outlier Factor and Time-to-failure prediction using Random Forest Regression) appear to have a high potential to reach the goals of the Challenge. However, there are a number of concrete things that would have to have been done by the Challenge providers and the Challenge moderators in order to ensure success. This includes enabling access to more details of the different failure types, access to multiple data sets from more wind turbines experiencing gearbox failure, provision of a model or rule relating fault detection times or a remaining useful lifetime to the estimated costs for repairs, replacements and inspections, provision of a clear strategy for training and test periods in advance, as well as provision of a pre-defined template or requirements for the results. These learning outcomes are used directly to define a set of best practice data sharing guidelines for wind turbine fault detection model evaluation. They can be used by the sector in order to improve model evaluation and data sharing in the future.
The Transverse Momentum Distribution of J/ψ Mesons Produced in Pp Collisions at the LHC
Authors: Gao Lina , Wang Erqin
Published: March 2023

The transverse momentum distribution of J/ψ mesons produced in pp collisions at the center-of-mass energy 5 TeV, 7 TeV，and 13 TeV is described by the modified Hagedorn function which is based on the Tsallis function and Hagedorn function. The calculated results by the modified Hagedorn function are in accord with experimental data measured by the LHCb Collaboration at LHC. The related parameters are obtained and analyzed.
Balancing Electricity Supply and Demand in a Carbon-Neutral Northern Europe
Authors: Göransson Lisa
Published: March 2023

This work investigates how to balance the electricity supply and demand in a carbon-neutral northern Europe. Applying a cost-minimizing electricity system model including options to invest in eleven different flexibility measures, cost-efficient combinations of strategies to manage varia-tions are identified. The results of the model are post-processed using a novel method to map the net load before and after flexibility measures are applied to reveal the contribution of each flexi-bility measure.
The net load is mapped in the space spanned by the amplitude, duration, and number of occur-rences. The mapping shows that, depending on cost structure, flexibility measures contribute to reduce the net load in three different ways; 1) by reducing variations of long duration but low amplitude, 2) by reducing variations of high amplitude but short duration and low occurrence or 3) by reducing variations of high amplitude, short duration and high occurrence. It is found that cost-efficient variation management is achieved by combining wind and solar power and by combining strategies (1-3) to manage variations. The cost-efficient combination of strategies de-pends on electricity system context where electricity trade, flexible hydrogen and heat production (1) manage the majority of variations in regions with good conditions for wind power while sta-tionary batteries (3) are the main contributors in regions with good conditions for solar power.
Trees on Farms Provide Both Wood Value and Conservation Value in a Tropical Forest System: A Case Study from Western Kenya
Authors: Espira Anton , Kefa Christopher , Lung Mark , Gregory Andrew J.
Published: March 2023

A primary challenge facing conservationists is reconciling the human needs of forest adjacent communities with the needs of conserving forest biodiversity, especially in tropical regions with growing populations of rural poor. Agroforestry has the potential to simultaneously provide for human needs and enhance forest biodiversity, but the complex interactions and feedbacks between the social and natural dimensions are relatively undescribed and thus systematic implementation is rare. The attributes of trees on farms required for human needs and conservation value may conflict. For example, exotic species in monoculture may provide the most economic value for farmers, while relic or planted indigenous tree mixtures may be more valuable for biological conservation. The objective of this study was to explore whether agroforestry practices in a moist tropical forest ecosystem in Kenya can simultaneously provide timber and fuelwood value to small-holder farmers while extending forest tree biodiversity. We described the agroforestry attributes on farms around a tropical forest, assessed the relationship between number and biomass of timber/fuelwood trees and tree biodiversity, and explored the relationships between forest tree diversity attributes and farm tree diversity attributes on a landscape scale using spatial analysis. We found that the diversity and number of trees on farms in this area are extensive yet variable, but that no significant relationship exists between the number of timber/fuelwood trees and tree diversity. This suggests that the two values of agroforestry may not be in conflict, due mainly to the high diversity of trees used for fuelwood. We also found that trees on farms in the larger landscape add to the conservation value of forest tree biodiversity and could be important components in conservation management. If agroforestry is to play an increasingly active role in conserving biodiversity in human-dominated landscapes, particularly in areas of dense subsistence farmer populations, increase recognition needs to be given to farmer’s perception of the value of trees and their selection of what trees to plant or maintain.
Potential for Impact of Workforce Nutrition Programmes on Nutrition, Health and Business Outcomes: a Review of the Global Evidence and Future Research Agenda
Authors: Nyhus Dhillon Christina , Ortenzi Flaminia
Published: March 2023

One in three people globally suffer from at least one form of malnutrition, leading to poor health outcomes and low productivity in the workplace. The workplace offers an important, relatively unexploited opportunity to address malnutrition in all its forms. This literature review aims to understand the potential for impact of workforce nutrition programmes on nutrition, health, and business outcomes, based on high-strength-of-evidence studies. We conducted a systematic search on PubMed and a rapid hand-search on Google Scholar to identify systematic reviews, meta-analyses, and randomized controlled trials published between January 2010 and October 2021. In total, 26 records were included. We found that comprehensive workforce nutrition programmes, including a variety of intervention areas, and/or programmes targeting high-risk categories of workers (overweight/obese or (pre-)diabetic) were more likely to be effective on nutrition, health, and business outcomes. Within comprehensive and targeted programmes, individualized counselling and environmental modifications were often mentioned as the most effective components. However, a high degree of heterogeneity in outcome measures and programme designs made it difficult to draw strong conclusions on impact of workforce nutrition interventions. Limited evidence was found on business outcomes, longer-term effects of interventions, and programme implementation in LMICs. Therefore, further research is needed to address these evidence gaps.
Correlation of Plasmatic Profiles of Inflammatory Cytokines/Chemokines and GFAP with Brain Damage Detected at MRI in Neonates with Hypoxic Ischemic Encephalopathy (HIE) Treated with Therapeutic Hypothermia: A Preliminary Study
Authors: Auriti Cinzia , Piersigilli Fiammetta , Mondì Vito , Timelli Laura , Del Pinto Tamara , Prencipe Giusi , Lucignani Giulia , Longo Daniela , Bersani Iliana
Published: March 2023

Background & Objective. Perinatal hypoxia acutely triggers the release of cytokines and chemokines from neurons, astrocytes and microglia. In response to hypoxia-ischemia resting/ramified microglia proliferate and undergo activation, with the production of proinflammatory molecules. The brain damage extension seems to be related with both the severity of hypoxia and the balance between pro and anti-inflammatory host response. Methods: In this preliminary study we compared in 10 neonates with hypoxic ischemic encephalopathy (HIE), during therapeutic hypothermia (TH), plasmatic cytokines and other inflammatory molecules levels: monocytic chemotactic-protein-1 (CCL2/MCP-1), CXCL8, glial fibrillary acidic protein (GFAP), Interferon gamma (IFN y), Interleukin 10 (IL-10), IL-18, IL-6, CCL3, ENOLASE2, Colony Stimulating Factor(GM-CSF), IL-1b, IL-12p70, IL-33, Tumor Necrosis Factor alpha(TNF), collected at four different time points during TH (24 hours, 25-48 hours, 49-72 hours) , and after the rewarming (7-10 days from birth). Five of enrolled babies had pathological brain MRI (“cases”) and 5 had a normal examination (“controls”). Cytokines were measured by Magnetic Luminex Assay (Luminex SV 013-17 (14), instrument Biorad Bio-Plex 100 s.n. LX 10005039304). MRI images were classified according to the Barkovich score. Results: Mean levels of all cytokines and molecules at time T1 were not significantly different in the two groups of patients. Comparing samples paired by day of collection, the greatest differences between cases and controls were found at times T2 and T3, during TH. After rewarming, some molecules showed an upward trend. At T4, levels tended to be close again (with the exception of IL-6, IL10 and IL18). Infants with worse MRI showed plasmatic GFAP levels higher than those with normal MRI, while their IL-18 was lower. Mean levels of CCL3MIP1alpha, GMCSF, IL1BETA overlapped throughout the observation period in both the groups of neonates. Conclusion. In children with worse brain MRI we found high levels of GFAP and of IL-10 at T4, considered respectively an early biomarker of brain damage and a predictor of adverse outcome, according to the literature, and a trend towards low IL-18 levels. We found the greatest, although not significant, difference between molecules levels in cases and controls at time points T2 and T3, during TH. With the rewarming some molecules showed an upward trend. We cannot exclude that the small sample size may prevent significance in the differences from being achieved.
The Effect of pH Value on Fertilized Eggs, Larva Fish and Juvenile Fish of Takifugu obscurus
Authors: Kong Xianghui , He Feng , Li Haoshuai
Published: March 2023

PH value is one of the most significant ecological factors affecting the survival and growth of aquatic organisms. But the effect and tolerance of pH value on many aquatic species are still unknown. This study mainly investigated the effects of pH value on the hatching rate of eggs, the adaptability of newly hatched larva fish and the survival of 3-months-old juvenile fish of Takifugu obscurus. Water pH values can cause a great impact on Takifugu obscurus lives, when the fertilized eggs of Takifugu obscurus were incubated at pH 5.0, 6.0, 7.0, 8.0, 8.3 (control group), 9.0, 10.0 and 11.0 respectively. Under the pH of 5.0, 6.0, 10.0 and 11.0, the hatching rate and speed is greatly reduced and the deformity rate of hatching larvae is greatly increased; When the hatch-pH value was 6.0, the acid adaption of hatched larvae was significantly enhanced, but alkali adaptation was weakened; Under the condition of pH gradient of 6.0, 6.4, 6.8, 7.0, 8.0, 8.3, 9.0, 10.0, 10.2, 10.5, 11.0 and 12.0, survival time and survival rate of juvenile fish show a significant difference. Especially when the pH value was 6.0 and 12.0, juvenile fish die immediately after swimming quickly. Within 24 h, half of the fish died at the pH of 6.4 and 10.3, and within 48 h, half died at the pH of 7.1 and 9.9. In addition, the gradual pH value group in which the pH value gradually decreased or increased had stronger acid-base adaptability and a higher survival rate than the acute experimental group. The above results show the relationship between pH value and survival of Takifugu obscurus, which can provide more reference for the introduction of Takifugu obscurus into saline-alkali land in the future. Additionally, the incubated pH value can influence the pH tolerance of Takifugu obscurus, which can be applied to the breed improvement into an appropriate water environment.
COVID-19, Seasonality, and Historical Epidemiological Risk in Italy: Descriptive Study and Considerations for Public Health
Authors: Rovetta Alessandro
Published: March 2023

(1) Background: This paper investigates the epidemiological risk related to temperature before and during COVID-19 in Italy; (2) Methods: Deaths in 2015-2019 and temperatures were correlated. Excess and COVID-19 deaths were examined to estimate the relationships with temperatures; (3) Results: Annual deaths were higher during the cold months (+45,000, SD = 4,700, S = 21). The scenario worsened during COVID-19. Mortality was higher during minimum temperature periods, although the curve moderately rose in the warmest months (r = -0.75, 95% CI = [-0.87; -0.56], S = 23). COVID-19 deaths showed a decreasing seasonality. Monthly excess deaths during COVID-19 were high (+4,200, IQR = [2,800; 8,000], S = 28) with a doubt of seasonality. COVID-19 mortality was correlated with regional latitude (r = 0.86, 95% CI = [0.68; 0.94], S = 20). Discrepancies between COVID-19 and excess deaths were found. The exposed population was subject to aging; (4) Conclusions: The epidemiological risk in Italy is seasonal and geographically dependent. Low and very high temperatures can lead to mortality peaks. Therefore, COVID-19 and any other epidemiological risk must be evaluated in light of this evidence. Health systems need to be strengthened during cold and extremely hot periods. Future research should investigate these phenomena at the causal level.
Best Formulation of Water-Based Slurry Making for Excellent Lithium Nickel Cobalt Aluminum Oxide (LiNi0.8Co0.15Al0.05O2) Performance
Authors: Hakam Miftakhul , Adristy Rheina Jelita , Chairinnisa Afifah Nur , Paramitha Tika
Published: March 2023

LiNi0.8Co0.15Al0.05O2 (NCA) is one of Ni-rich in Li-ion battery cathode family that offers capacity around 200 mAh/gram high energy density, low cost, non-toxicity, and superior thermal stability. To produce some good performance of the batteries, it’s needed the best slurry which is prepared for coating process making in water-based system. Due to remarkably improved the bonding capacity, cycle stability, rate performance of battery cathode. The formula of Lithium Nickel Cobalt Aluminum Oxide (LiNi0.8Co0.15Al0.05O2 or NCA): Acetylene Black (AB): Carboxymethyl Cellulose (CMC): Styrene Butadiene Rubber (SBR) is has many ratios as 80:10:5:5, 80:10:3:7, 90:6:2:2, 90:5:2:3, 85:10:2:3, and 80:15:2:3. All of formula can stick on Al-foil, so the electrode sheet can make by aqueous-based system but should be have appropriately formula and some of slurry not enough to coat on Al-foil because it has less slurry. Summary all of cathode sheet has voltage 3.7 V. The formula has the capacity/gram around 121.1-132.8 mAh/gram and efficiency around 85%-97%, Formula 4 (90:5:2:3) is best formula has high capacity when compare with another formula and after calculate that has capacity/gram 132.8 mAh/gram and high efficiency 95-97%.
Propuesta de un sistema experto para mejorar el proceso de orientación vocacional de los estudiantes del Colegio José María Arguedas, Junín-2019
Authors:   , Balvin Villalva Renato Kevin
Published: March 2023

En la actualidad la elección de una carrera profesional es un proceso muy complejo para los estudiantes de educación secundaria, esto se debe a que existen diferentes factores que influyen en la decisión. Entre las cuales están: factores personales, familiares, sociales entre otros. La complejidad de está difícil decisión surge debido a que cada joven se encuentra en un momento en el que está en proceso de definir su personalidad, identidad es ahí donde se generan conflictos a la hora de elegir una vocación Profesional. Asimismo, la falta de información por parte de los centros superiores de enseñanza dificulta esta decisión. Por otro lado, los centros de enseñanza de educación secundaria cumplen un papel importante durante la formación de los estudiantes, es por ello que todas las instituciones educativas deberían tener un adecuado proceso de orientación vocacional en beneficio de cada uno de los estudiantes. La investigación tiene por finalidad identificar los principales puntos críticos de una Orientación Vocacional para así mejorar el Proceso de Orientación Vocacional. En primer lugar, se detalla una descripción del problema. En segundo lugar, se detalla todo el marco teórico. En tercer lugar, se detallado los puntos clave de la gestión de todo el proyecto de la Investigación. Finalmente se presenta los recursos necesarios y tiempo estimado de la Investigación.
Importancia y funcionalidad de probióticos en la producción de pollos de engorde
Authors:   , Schaus Koch Luis Fernando
Published: March 2023

El siguiente trabajo de investigación se centra en la nueva tendencia en estos tiempos, sobre los probióticos, la importancia de estos y sus principales características, así como también sobre el uso de esta biotecnología en la industria avícola específicamente relacionada a los pollos de engorde. Los probióticos vienen a ser un conjunto de bacterias benéficas y levaduras, que pueden tener múltiples funciones que favorecen el desarrollo y promueven la salud del tracto gastrointestinal, por ende mejoran el bienestar de estos animales permitiéndoles en muchos casos alcanzar mejores índices productivos, mediante diversos mecanismos tales como la exclusión competitiva, la producción de sustancias antimicrobianas y captura de los receptores de la superficie de la mucosa intestinal de las aves. También se habla sobre algunos rasgos y características de los pollos de engorde tales como su capacidad productiva, desarrollo de su sistema digestivo y su alta capacidad de transformación del alimento a nutrientes, y también sobre la microbiota que estos animales presentan con normalidad en sus intestinos mostrando el equilibrio que debe mantenerse y su importancia para mantener una mejor salud del ave así como también potenciar sus capacidades productivas y de generar masa muscular a partir de su elevado metabolismo. En si se concluye en la importancia y funcionalidad que los probióticos tienen, y su funcionalidad para ayudar a mantener un equilibrio a nivel la flora intestinal de un ser vivo, lo cual se va ver reflejado tanto en su capacidad productiva como en su salud.
Uso de saponinas de origen natural para el control de coccidiosis aviar en pollos de engorde
Authors:   , Cerón Chacón Franchesca Elizabeth
Published: March 2023

En el presente trabajo de investigación se realizó una revisión bibliográfica general de la Coccidiosis aviar y el efecto de las saponinas, pues debido a la actividad que presenta, principalmente antiprotozoario, sería una alternativa natural para el control de esta enfermedad, concluyendo que el uso de las saponinas tendría un efecto favorable para el control de la Coccidiosis aviar en pollos de engorde debido a los resultados obtenidos en trabajos experimentables donde se observó principalmente que redujo la producción de ooquistes de Eimeria; sin embargo, se requieren más estudios para implementar esta estrategia de control en la alimentación de los pollos de engorde.
Impacto en la metodología COBIT en el control interno de tecnología de la información de instituciones financieras peruanas, 2016
Authors:   , Campos Medina Víctor Hugo Santiago
Published: March 2023

La investigación tiene por título “Impacto de la metodología COBIT en el control interno de TI en instituciones financieras peruanas, (bancos) 2016”, la cual tiene por objetivo proponer una metodología personalizada para la evaluación del control interno de TI para empresas del sector financiero peruano, especialmente el sector bancario, considerando que actualmente se encuentran en un proceso de cambio originado por la coyuntura económica y el reforzamiento de la leyes y regulaciones a nivel mundial y que son formuladas a través de la SBS. Se identificó el problema como la ausencia de una metodología de trabajo uniformizado para el sector financiero, ya que cada una aplica sistemas de acuerdo a su realidad, donde la experiencia y conocimiento del personal de auditoria en TI propone estos modelos de trabajo. Se plantea la hipótesis alternante: Cómo una metodología de control interno de TI, uniforme y estandarizada puede incrementar la eficiencia de las actividades en la organización y permite generar un valor agregado alineado a las expectativas de los directores, Accionistas y Partes Interesadas de la institución financiera. La metodología empleada es de tipo cuantitativa, no experimental, transversal con un tamaño de muestra de 93 encuestas. Entre los resultados se puede mencionar que la variable Planeación y Organización (PO) influye en la eficacia del control de interno de TI en las instituciones financieras (bancos) de manera positiva en 17 puntos; además la variable Adquisición e implementación (AI) influye de forma positiva en 6.5 puntos; mientras que las variables de Entregar Servicio y Dar Soporte (DS) y Monitorear y Evaluar no representan aspectos relevantes para influir en la eficacia del control interno de TI.
Percepción de uso de los elementos de un aula virtual para el aprendizaje del idioma inglés en las universidades de Lima, Perú
Authors:   , La Torre Castillo Carlos Celso
Published: March 2023

Percepción de uso de los elementos de un aula virtual para el aprendizaje del idioma inglés en las universidades de Lima, Perú Carlos Celso La Torre Castillo 10219158 La profundización del uso de herramientas virtuales para los procesos de enseñanza aprendizaje requieren de mejoras en su implementación, experiencias positivas y una actitud proactiva de parte de docentes y estudiantes. Se realizó un estudio transversal con el objetivo de conocer la percepción de estudiantes universitarios de universidades privadas de Lima sobre el uso de elementos que debe tener un aula virtual para el aprendizaje del idioma inglés. Se incluyó 150 estudiantes de contabilidad de cinco universidades, se evaluó la percepción de los diferentes elementos del aula virtual y se comparó según experiencia previa. La mayoría de los estudiantes estuvo a favor del uso de aula virtual y sus diferentes elementos, quienes tuvieron experiencia previa estuvieron más a favor del uso de recordatorios, chats, foros, correos y ejercicios online (p<0,05). En conclusión, la mayoría de los estudiantes está a favor del uso de aula virtual y la experiencia previa favorece una mejor percepción de las herramientas para el aprendizaje online.
Frecuencia y factores asociados a dermatosis de origen endócrino en caninos atendidos en una clínica veterinaria en Lima - Perú entre los años 2006 - 2020
Authors:   , Morillo Alfaro Astrid Guadalupe
Published: March 2023

El objetivo de este estudio fue evaluar la frecuencia y factores asociados a dermatosis de origen endócrino en caninos atendidos en una clínica veterinaria en Lima - Perú entre los años 2006-2020. Se revisaron historias clínicas de caninos de la clínica veterinaria Pets On Board, considerándose las variables de edad, sexo, raza y endocrinopatía. La frecuencia de las dermatosis se determinó con relación al total de historias clínicas de caninos. Se diagnosticaron (17/565) dermatosis de origen endócrino (3.01%). El mayor número de casos se encontró en animales de raza pura (88.2%), de más de 6 años (88.2%) y sexo hembra (58.8%). Además, el hipotiroidismo fue la dermatosis endócrina de mayor frecuencia (47.07%).
Percepción del aprendizaje de criocirugía en médicos residentes y asistentes del servicio de dermatología de un Hospital del Perú
Authors:   , Mosquito Saldaña Fabiola Vanessa , Rivera Sulca Angélica Matilde
Published: March 2023

OBJETIVO: Determinar la percepción del aprendizaje de criocirugía en los médicos residentes y asistentes de dermatología. MATERIAL Y MÉTODOS: Es un estudio no experimental, descriptivo y transversal. Se incluyeron 10 médicos residentes y 4 médicos asistentes de dermatología de un hospital de Perú. Se aplicó una encuesta a los residentes y una entrevista semiestructurada a los asistentes. RESULTADOS: El 100% de los residentes consideró mayor destreza después de recibir capacitación en Criocirugía. El 50% residentes recibió seguimiento por los docentes del hospital después de la capacitación en Criocirugía. El 40% de los residentes consideró la criocirugía importante por su uso fácil y el 30% por su accesibilidad. Los médicos asistentes refirieron que la capacitación en criocirugía debe darse durante los 3 años de formación. CONCLUSIÓN: Los médicos residentes y asistentes de dermatología coincidieron en que es importante la capacitación y seguimiento en Criocirugía durante los 3 años de residencia.
Performance Analysis of Spatial Modulation in
Cooperative Cognitive Radio Networks with Energy
Harvesting
Authors: JALAJA RENJITH RAVINDRAN UNNITHAN , T VETRIVEL CHELIAN , PGS VELMURUGAN , J THIRUVENGADAM S
Published: March 2023

Inspired by the stringent requirements of energy efficiency and spectral efficiency for future wireless communication networks, a novel Spatial Modulation Assisted Cooperative Cognitive Radio Network with Energy Harvesting (SM-CCRN-EH) is proposed in this paper. It is well known that Cognitive Radio (CR) is a promising solution to mitigate the effect of spectrum scarcity using unlicensed bands in spectrum. In the proposed CR network, SM is applied at both Primary Transmitters (PT) and Secondary Transmitter (ST) to improve spectral efficiency. The ST acts as a Decode and Forward (DF) energy harvested relay node. It uses multiple antennas for receiving signal from PT and single antenna for signal transmission. Energy harvesting at the ST is possible using time switching or power splitting protocol to improve the energy efficiency of the system. In order to quantify the reliability of the proposed system, closed form expressions are derived for outage probability and Bit Error Rate (BER) at the Primary Receiver (PR) and Secondary Receiver in both time slots. Computer simulations are performed to verify the accuracy of derived analytical expressions. It is observed that there is an excellent agreement for both analytical results and computer simulations.
Saxitoxins and Pain management: A systematic review
Authors: Nourian Yazdan Hasani , Afraz Shaghayegh , Arabfard Masoud , Borna Hojat , ghanei mostafa
Published: March 2023

Background
From a clinical and economic viewpoint, pain management is critical. A class of drugs known as local anesthetics is used to treat pain caused by neurological conditions. Saxitoxin (STX) and its analogues are among the Nav blocking toxins that have recently received much attention in pain control. The goal of this study is to conduct a systematic review of the evidence for using STXs in pain management.
Method
A systematic search was conducted for randomized studies using STX and analogs in the treatment of pain. With no time or language limitations, this study employed a three-database search technique that included SCOPUS, PUBMED, and EMBASE.
Results
134 studies were identified, and 7 included. From these publications, every information concerning the type of analog used, its efficacy, dose, and adverse effects was retrieved and discussed in detail.
Discussion
In human studies, the combination of local anesthetics with STX and its analogues, notably Neosaxitoxin, increased the duration of action and reduced the dosage needed to treat neuropathic pain. This effectiveness was also confirmed in numerous animal models.
Conclusion
According to this research, this family of toxins can be highly efficient in controlling and managing pain that has a neurological basis, and they should be investigated further for usage in this type of pain.
Identification and molecular characterization of high-yielding charcoal rot resistant soybean genotypes
Authors: Amrate Pawan , Srivas M.K. , Bhale M.S , Agrawal Nisha , Kumawat Giriraj , Shivakumar M , Nataraj Vennampally
Published: March 2023

Charcoal rot disease caused by Macrophomina phaseolina (Tassi) Goid is one of the most devastating diseases in soybean in India. During 2018, a total of 226 diverse soybean genotypes have been evaluated for charcoal rot resistance under hot-spot conditions. Out of 226 genotypes, a sub set of 151 genotypes were selected based on disease reaction and better agronomic performance. Out of 151 genotypes evaluated during 2019, 43 genotypes were selected based on disease reaction and superior agronomic performance for their further field evaluation and molecular characterization. Disease evaluation during 2018 and 2019 was through Percent Disease Incidence (PDI). During 2020 and 2021, these forty three genotypes, were evaluated for PDI, Area Under Disease Progress Curve (AUDPC), and grain yield. During 2020, genotype JS 20–20 was found to show least PDI (0.42) and AUDPC (9.37), and highest grain yield was recorded in the genotype JS 21 − 05 (515.00 g). During 2021, genotype JS 20–20 observed to exhibit least PDI (0.00) and AUDPC (0.00), and highest grain yield was recorded in JS 20–98 (631.66 g). Across both the years, JS 20–20 was found to show the least PDI (0.21) and AUDPC (4.68), while grain yield was highest in JS 20–98 (571.67 g). Through MGIDI (multi-trait genotype-ideotype distance) analysis, JS 21 − 05 (G19), JS 22 − 01 (G43), JS 20–98 (G28) and JS 20–20 (G21) were identified to be the ideotypes with respect to the traits under consideration. Two unique alleles, Satt588 (100 bp) on linkage group K and Sat_218 (200 bp) on linkage group H, were found to be specific to two resistant genotypes JS 21-71and DS 1318, respectively. Through clustering pattern, it was observed that the genotypes bred at Jabalpur are genetically more closely related.
The level of protein in the maternal murine diet modulates the facial appearance of the offspring via mTORC1 signaling
Authors: Chagin Andrei , Xie Meng , Tesarova Marketa , Gershtein Yaakov , Schnyder Daniela , Devyatirov Ruslan , Gazizova Guzel , Shagimardanova Elena , Zikmund Tomas , Kerckhofs Greet , Ivashkin Evgeny , Batkovskyte Dominyka , Newton Phillip , Andersson Olov , Fried Kaj , Gusev Oleg , Zeberg Hugo , Kaiser Jozef , Adameyko Igor
Published: March 2023

The development of craniofacial skeletal structures is fascinatingly complex and elucidation of the underlying mechanisms will not only provide novel scientific insights, but also help develop more effective clinical approaches to the treatment and/or prevention of the numerous congenital craniofacial malformations. To this end, we performed CAGE-sequencing of the facial mesenchyme of human embryos and cross-checked the active enhancers thus identified against genes, identified by GWAS for the normal range human facial appearance. Among the identified active cis-enhancers, several belonged to the components of the mTORC1 (Mechanistic Target of Rapamycin Complex 1) pathway. To assess the functional role of this pathway, we manipulated it both genetically and pharmacologically in mice and zebrafish. These experiments revealed that mTORC1 signaling modulates craniofacial shaping at the stage of skeletal mesenchymal condensations, with subsequent fine-tuning during clonal intercalation. This ability of mTORC1 pathway to modulate facial shaping, along with its evolutionary conservation and ability to sense external stimuli, in particular dietary amino acids, indicate that the mTORC1 pathway may play a role in facial phenotypic plasticity. Indeed, the level of protein in the diet of pregnant female mice influenced the activity of mTORC1 in fetal craniofacial structures and altered the size of skeletogenic clones, thus exerting an impact on the local geometry and craniofacial shaping. Overall, our findings indicate that the mTORC1 signaling pathway is involved in the effect of environmental conditions on the shaping of craniofacial structures.
Decomposition and sources of Gender Inequality in Access to drinking water in Cameroon: Does International remittances matter?
Authors: MEKA’A BERNARD COSMAS , BITA CHARLES ALAIN , noufelie ROMUS
Published: March 2023

This paper quantify and decompose the Gender Gap in Access to Drinking Water (ADW) in Cameroon, emphasizing the international remittance impacts. To do this, a nonlinear decomposition technique is applied to the data from a survey of 5930 households led in 2012 by Demographic Research and Training Institute (DRTI) with the collaboration of Africa, Caribbean and Pacific migration organisation. We distinguish the remittances from only male migrants (MIRM) from those all migrants (OIRM). The performing a Boostrap analysis show a significant gender gap in ADW; and that female household heads have greater ADW than their counterpart male ones. Moreover, heterogeneity to remittance recipient widen the gap remittances widen the male-female gap in ADW, but the MIRM impact is largest than OIRM ones. Our finding further confirm the hypothesis stipulating that: adverse distributional effect of remittances depend onof household head and migrant gender. We therefore agree with already existing conclusions in the economic literature.
JEL Code: D31, O15, F22 F24 J16
Investigation of a rare occurrence of a diatomaceous coating of the Cotswold Weir wall on the Condamine River, Australia
Authors: Thompson John P. , Standley John , Hancock Rachel C.
Published: March 2023

A white encrustation of the Cotswold Weir wall in the lower reaches of the Condamine River, a tributary of the Murray-Darling River system in semi-arid Australia, was investigated following community concern that the substance indicated health risks from the water. The vitreous white surface consisted of closely packed frustules of diatoms, observed by scanning electron microscopy, with an underlying layer of clay particles and dried filamentous green algae. Pennate diatoms identified in the white encrustation were the benthic species Nitzschia palea (predominant), Eolimna subminiscula, Craticula aff. cuspidata, Navicula viridula var. rostellata, and Luticola mutica. The centric diatom species Melosira varians was also present as filamentous chains among the aggregated pennate diatom frustules. The encrustation was the remains of a periphyton (biofilm) of diatoms and green algae that had developed during protracted stream flow over the weir wall following record flooding. A dry period had resulted in death of the diatoms and exposure of their aggregated siliceous frustules as a vitreous white coating. All diatom species identified are considered tolerant of eutrophic and mildly saline conditions. Chemical analyses of water from the Cotswold Weir, compared to long-term records, revealed higher salinity as measured by electrical conductivity and higher sodium and chloride concentrations, total nitrogen and total phosphorus with wide atomic ratios for total nitrogen:total phosphorus, nitrate-nitrogen:orthophosphate-phosphorus and dissolved silica–silicon:orthophosphate-phosphorus that probably favoured diatoms over other photoautotrophs. While the diatomaceous encrustation indicated no health risks from the weir water, continued watch is required to avoid eutrophication and salinization of the river.
Concept analysis of health system resilience
Authors: Asfoor Deena Al , Tabche Celine , Zidjali Manal Al , Mataria Awad , Saikat Sohel , Rawaf Salman
Published: March 2023

Background: Although several definitions of health systems resilience have many common characteristics, there is no agreed-upon framework that could be used to measure resilience. In this review, we review the concept of resilience, identifying definitions, attributes, antecedents, and consequences and present the findings of the ‘concept analysis’ of Health System Resilience.
Methods: In this paper, we follow Schwarz-Barcott and Kim’s Hybrid model, which consists of theoretical, fieldwork and final analytical phases. This review identifies the health systems resilience definitions, attributes, antecedents, and consequences with the aim of developing a framework to identify the domains that could constitute a measure.
We searched PubMed, PsycINFO, CINAHL Complete, Ebscohost- Academic Search Premier to download titles and abstracts on Covidence. The articles were screened by two reviewers and disagreements were resolved by discussion with the third reviewer. Each of the three reviewers examined the eligible publications for definitions, attributes, antecedents, and consequences using a pre-defined data extraction form.
Results: The initial search yielded 3357 articles. Duplicates and ineligible articles were removed. These were further screened, and 66 of them were removed because they did not include a discussion of health systems resilience, discussed resilience but not in a health systems context, were in languages other than English and did not discuss resilience, and we could not access two full articles. Finally, we included 130 studies in the analysis.
Conclusions: Resilience antecedents are decentralization, available funds, investments and resources, staff environment and motivation, integration and networking, and finally, diversification of the staff. The attributes are the availability of resources and funds, adaptive capacity, transformative capacity, learning and advocacy, and progressive leadership. The consequences of health system resilience are improved health system performance, a balanced governance structure, improved expenditure and financial management of health, and maintenance of health services that support UHC throughout crises. We propose a framework as a basis of a measurement tool for health system resilience.
Establishment and Validation of Diagnostic Model of Microvascular Invasion in Hepatocellular Carcinoma
Authors: Wang Xiu-Qin , Hou Dong-Xing , Fan Ying-Qi , Pan Cui-Cui , Zheng Ni , Si Yuan-Quan
Published: March 2023

Background: Microvascular invasion (MVI) is closely related to high recurrence and poor prognosis in patients with hepatocellular carcinoma (HCC). We aimed to establish a preoperative diagnostic model of MVI for HCC based on the clinical characteristics and serum detectors of HCC patients.
Methods: In total, 1027 hepatocellular carcinoma patients hospitalized at Shandong Provincial Hospital from January 2016 to August 2021 were included and randomly divided into the development group and validation group at a ratio of 3:1. Independent sample t test, Mann-Whitney U test, Chi-square test and Fisher exact test were applied to assess the difference of clinical characteristics and serum index results of the two cohorts. Univariate and multivariate logistic regression analyses were carried out to screen the independent risk factors of HCC patients with microvascular invasion. By using these independent risk factors, a preoperative diagnostic nomogram of HCC for MVI was established and verified. The receiver operating characteristic (ROC) curves, calibration curves and decision curve analyses (DCA) were used to estimate the discrimination and clinical application of the nomogram. In addition, the value of this diagnosticmodel in diagnosing microvascular invasion in different stages of hepatocellular carcinoma was further discussed.
Results: Through univariate and multivariate analyses, independent riskfactors for MVI of HCCinvolved Hepatitis B virus infection (HBV), large tumor diameter, higher logarithm of Alpha-fetoprotein (Log AFP), higher logarithm of AFP-L3% (Log AFP-L3%), higher logarithm of protein induced by vitamin K absence or antagonist-II (Log PIVKA-II) and higher logarithm of Carbohydrate antigen 125 (Log CA125). The nomogramincorporating these six independent risk factors was finally established. The areas under the ROC curve (AUC) assessed by the nomogram for MVI of HCC in development cohort and validation cohort were 0.806 (95% CI, 0.773～0.839) and 0.818 (95% CI, 0.763～0.874) respectively. The calibration curve revealed that the judged results for MVI of hepatocellular carcinoma using our established diagnostic model were highly consistent with the postoperative pathological results. The decision curve analysis (DCA) showed promising clinical application of the diagnostic nomogram. Moreover, we also found that the diagnostic model had better application value in hepatocellular carcinoma with higher malignancy.
Conclusion: An effective preoperative diagnostic model for MVI of HCC based on readily available tumor markers and clinical characters has been established, which can be significant and easily implemented for MVI diagnosis.