bluuebunny/crossref_metadata_2025 huggingface dataset:
Table S6 from Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma
Authors: Faramand Rawan G. , Lee Sae Bom , Jain Michael D. , Cao Biwei , Wang Xuefeng , Rejeski Kai , Subklewe Marion , Fahrmann Johannes F. , Saini Neeraj Y. , Hanash Samir M. , Kang Yun Pyo , Chang Darwin , Rodriguez Paolo C. , Dean Erin A. , Nishihori Taiga , Shah Bijal D. , Lazaryan Aleksandr , Chavez Julio , Khimani Farhad , Pinilla-Ibarz Javier A. , Dam Marian , Reid Kayla M. , Corallo Salvatore A. , Menges Meghan , Hidalgo Vargas Melanie , Mandula Jay K. , Holliday Brian A. , Bachmeier Christina A. , Speth Kelly , Song Qinghua , Mattie Mike , Locke Frederick L. , Davila Marco L.
Published: March 2024

Table S6: Clinical outcomes of high-risk patients
Figure S2 from Baseline Serum Inflammatory Proteins Predict Poor CAR T Outcomes in Diffuse Large B-cell Lymphoma
Authors: Faramand Rawan G. , Lee Sae Bom , Jain Michael D. , Cao Biwei , Wang Xuefeng , Rejeski Kai , Subklewe Marion , Fahrmann Johannes F. , Saini Neeraj Y. , Hanash Samir M. , Kang Yun Pyo , Chang Darwin , Rodriguez Paolo C. , Dean Erin A. , Nishihori Taiga , Shah Bijal D. , Lazaryan Aleksandr , Chavez Julio , Khimani Farhad , Pinilla-Ibarz Javier A. , Dam Marian , Reid Kayla M. , Corallo Salvatore A. , Menges Meghan , Hidalgo Vargas Melanie , Mandula Jay K. , Holliday Brian A. , Bachmeier Christina A. , Speth Kelly , Song Qinghua , Mattie Mike , Locke Frederick L. , Davila Marco L.
Published: March 2024

Figure S2 shows the optimal CRP (A) and ferritin (B) cut offs for overall survival
Supplementary Table 1 from Synergistic Drug Combinations Promote the Development of Resistance in Acute Myeloid Leukemia
Authors: Mason-Osann Emily , Pomeroy Amy E. , Palmer Adam C. , Mettetal Jerome T.
Published: March 2024

Supplementary Table 1 - Materials
Supplementary Figures from Synergistic Drug Combinations Promote the Development of Resistance in Acute Myeloid Leukemia
Authors: Mason-Osann Emily , Pomeroy Amy E. , Palmer Adam C. , Mettetal Jerome T.
Published: March 2024

Supplementary Figures 1-5
Data from IDH1-Mutant Preleukemic Hematopoietic Stem Cells Can Be Eliminated by Inhibition of Oxidative Phosphorylation
Authors: Landberg Niklas , Köhnke Thomas , Feng Yang , Nakauchi Yusuke , Fan Amy C. , Linde Miles H. , Karigane Daiki , Lim Kelly , Sinha Rahul , Malcovati Luca , Thomas Daniel , Majeti Ravindra
Published: March 2024

Abstract
Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the origin of leukemia and a potential reservoir for relapse. Using primary human samples and gene editing to model isocitrate dehydrogenase 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, and metabolic differences between pHSCs and healthy hematopoietic stem cells (HSC). We confirm that IDH1-driven clonal hematopoiesis is associated with cytopenia, suggesting an inherent defect to fully reconstitute hematopoiesis. Despite giving rise to multilineage engraftment, IDH1-mutant pHSCs exhibited reduced proliferation, blocked differentiation, downregulation of MHC class II genes, and reprogramming of oxidative phosphorylation metabolism. Critically, inhibition of oxidative phosphorylation resulted in the complete eradication of IDH1-mutant pHSCs but not IDH2-mutant pHSCs or wild-type HSCs. Our results indicate that IDH1-mutant preleukemic clones can be targeted with complex I inhibitors, offering a potential strategy to prevent the development and relapse of leukemia.
Significance:
A high burden of pHSCs is associated with worse overall survival in AML. Using single-cell sequencing, metabolic assessment, and gene-edited human models, we find human pHSCs with IDH1 mutations to be metabolically vulnerable and sensitive to eradication by complex I inhibition.

See related commentary by Steensma, p. 83.

This article is featured in Selected Articles from This Issue, p. 80
FIGURE 9 from A Pilot Study on Patient-specific Computational Forecasting of Prostate Cancer Growth during Active Surveillance Using an Imaging-informed Biomechanistic Model
Authors: Lorenzo Guillermo , Heiselman Jon S. , Liss Michael A. , Miga Michael I. , Gomez Hector , Yankeelov Thomas E. , Reali Alessandro , Hughes Thomas J.R.
Published: March 2024

Patient-specific forecasts of prostate cancer risk. A–D, Time trajectories of the model-based markers involved in the calculation of our prostate cancer risk classifier (left) as well as the trajectory of the latter (right) for 4 patients. The patients shown in this figure are the same considered in Figs. 4 and 6. In all panels, darker hues represent results from the global calibration scenario (GC, see Fig. 4), where the model is fit to the three mpMRI datasets from each patient, while lighter hues show results from the fitting-forecasting scenario (FF, see Fig. 6), where the model is only fit to the first two mpMRI datasets from each patient. Dotted gray vertical lines in the background indicate the times of the mpMRI scans for each patient. Solid lines correspond to quantities calculated from the model fit, while dashed lines correspond to values calculated from model forecasts. The model-based markers of interest are the total tumor index (NT, green curves, left vertical axis) and mean proliferation activity of the tumor (Ap, pink curves, right vertical axis). The prostate cancer risk classifier was trained with the global calibration results (see Fig. 8), yielding an optimal performance threshold that separates lower risk prostate cancer (blue region) from higher-risk prostate cancer (red region). The prostate cancer risk at the times of histopathologic assessment of the tumors (i.e., biopsy, surgery) is represented as a bullet point, and the corresponding GS values are annotated over the prostate cancer risk trajectory from the global calibration scenario. In A, the patient exhibits a low-risk tumor during AS, which is correctly identified by our classifier in both computational scenarios. In B, our model consistently classifies the patient's tumor as higher-risk during the majority of AS in both computational scenarios. In C, the patient initially exhibits a lower-risk tumor that had progressed to higher-risk at the time of surgery (i.e., terminal GS value). In the fitting-forecasting scenario our model consistently predicts that the tumor is a higher-risk case, while, in the global calibration scenario, tumor progression is detected shortly after the second mpMRI scan. Importantly, in the fitting forecasting scenario, our approach identifies a higher-risk tumor 1,011 days earlier than standard practice (i.e., assessment of the surgical specimen). In D, our model consistently identifies the tumor as a higher-risk case in both computational scenarios.
FIGURE 5 from A Pilot Study on Patient-specific Computational Forecasting of Prostate Cancer Growth during Active Surveillance Using an Imaging-informed Biomechanistic Model
Authors: Lorenzo Guillermo , Heiselman Jon S. , Liss Michael A. , Miga Michael I. , Gomez Hector , Yankeelov Thomas E. , Reali Alessandro , Hughes Thomas J.R.
Published: March 2024

Summary of metrics assessing the performance of the biomechanistic model during global calibration. A and B, Unity plots to assess the agreement between the model estimation and mpMRI measurement of the tumor volume (VT) and the total tumor cell volume (VN) across the patient cohort (n = 7). These global tumor metrics were calculated at the dates of the second and third mpMRI scans (blue and green points). The unity plots in A and B also report the corresponding PCC and CCC for the global tumor metrics at the dates of the second and third mpMRI scans. C–F, Distributions of four local metrics assessing the agreement between the tumor cell density map calculated with our biomechanistic model and extracted from mpMRI data across the patient cohort in the global calibration scenario: Dice similarity coefficient (DSC), root mean squared error (RMSE), Pearson correlation coefficient (PCC), and concordance correlation coefficient (CCC). These local metrics were calculated at the dates of the second and third mpMRI scans (blue and green boxplots).
Interação no telejornalismo brasileiro: sentidos e reflexos do enfrentamento tecnológico
Authors: Vieira Mônica de Fátima Rodrigues Nunes , Amaral Patrícia Aparecida , Morais Osvando José de
Published: March 2024

Esta pesquisa visou entender, por meio do aplicativo WhatsApp, as características da interação entre audiência e telejornal da TV Integração, afiliada à Rede Globo e, ainda, como a produção do programa a utilizou. Para isso, realizou-se pesquisa bibliográfica e análise de conteúdo de 4.978 mensagens recebidas entre dezembro de 2021 e junho de 2022. Os resultados da investigação apontam que a comunicação feita pelo aplicativo entre o público e os jornalistas é uma interação mediada, e que a seleção e a veiculação da participação se apresentam como um novo formato da categoria informativa do telejornalismo, que rompe, de maneira discreta, o aspecto monológico da TV.
Descolonizando a capital: cartografia político-afetiva de corpos errantes pela cidade de Brasília
Authors: Freitas Gabriela
Published: March 2024

A partir da análise de intervenções urbanas de quatro artistas e coletivos do centro e da periferia do Distrito Federal, proponho a elaboração de uma breve cartografia político-afetiva de Brasília, cujo projeto urbanístico original se caracteriza por constituir um dispositivo urbano segregacionista que confere à cidade, até hoje, uma das maiores desigualdades sociais do país. Para tanto, recorro inicialmente à concepção de estética decolonial como aporte teórico-epistemológico para descentralizar o papel da representação e do estímulo visual nas artes de modo a priorizar outras formas de produção de sentido pela aisthesis, colocando o corpo como agente de ocupação da cidade, conforme proposto pela prática do delirium ambulatorium em Hélio Oiticica. Encontro, nos artistas abordados, reverberações do pintor e escultor tropicalista na prática estética do caminhar e da errância como possibilidade de fundir o corpo ao espaço, constituindo um modo subversivo de compreender a formação de subjetividades no contexto urbano neoliberal.
Diferenças e semelhanças no emprego da imagética "rústica" em Ars amatoria e Remedia amoris
Authors: Trevizam Matheus
Published: March 2024

Neste artigo, desejamos explorar o aspecto da imagética rústica em Ars amatoria e Remedia amoris. Por “imagética rústica”, entendemos o uso de metáforas, comparações ou verdadeiras descrições de gestos de personagens vinculados a atividades agrícolas ou de caça. Dessa forma, procedendo comparativamente na análise das duas obras citadas, intenta-se demonstrar que, semelhanças à parte, o emprego da imagética rústica (figurada ou não) assume significados distintos em cada qual, devido, sobretudo, ao fato de Ars amatoria servir-se desse recurso para incentivar o amor; mas, em Remedia amoris, o poeta ensina como coibi-lo, se é infeliz.
Hypertension, Neurodegeneration, and Cognitive Decline
Authors: Pacholko Anthony , Iadecola Costantino
Published: March 2024

Elevated blood pressure is a well-established risk factor for age-related cognitive decline. Long linked to cognitive impairment on vascular bases, increasing evidence suggests a potential association of hypertension with the neurodegenerative pathology underlying Alzheimer disease. Hypertension is well known to disrupt the structural and functional integrity of the cerebral vasculature. However, the mechanisms by which these alterations lead to brain damage, enhance Alzheimer pathology, and promote cognitive impairment remain to be established. Furthermore, critical questions concerning whether lowering blood pressure by antihypertensive medications prevents cognitive impairment have not been answered. Recent developments in neurovascular biology, brain imaging, and epidemiology, as well as new clinical trials, have provided insights into these critical issues. In particular, clinical and basic findings on the link between neurovascular dysfunction and the pathobiology of neurodegeneration have shed new light on the overlap between vascular and Alzheimer pathology. In this review, we will examine the progress made in the relationship between hypertension and cognitive impairment and, after a critical evaluation of the evidence, attempt to identify remaining knowledge gaps and future research directions that may advance our understanding of one of the leading health challenges of our time.
A Flock of One’s Own: Nordic Human-Mountain Cattle Kinship-Making Practices
Authors: Kroløkke Charlotte , Nørkjær-Bang Anne , Ovaska Ulla , Honkatukia Mervi
Published: March 2024

This article employs critical cultural and anthropological perspectives to investigate the ways in which Nordic mountain cattle are kinned and become positioned as kin. It does so by empirically foregrounding photographic material, elicited from the 3MC Traditional Transboundary Cattle Breeds’ photo competition, along with photo elicited interviews with 13 of the participating photographers. Nordic mountain cattle become “kinned” as “mothers,” “family members,” “friends,” “colleagues,” and “pets” through a range of kinship-making practices such as naming, gendering, and anthropomorphizing cattle with distinct human-like personalities. The article concludes by turning to the affective values and cultural logics that situate mountain cattle as forms of Nordic cultural heritage. In these entanglements, mountain cattle resurrect Nordic cultural heritage and temporality facilitating new Nordic naturecultures in which humans are simultaneously (re)connected to nature and cultivated as future (new) citizens.
Event Religion
Authors: Heidl Sára Eszter
Published: March 2024

This article examines some of the changing forms of religion in contemporary Hungary, with a focus on a case study conducted at a mindfulness and lifestyle festival called Everness. The emerging need for an alternative kind of spirituality supplementing or opposed to traditional forms of religion has generated a new conceptual approach that I call event religion. In inductive empirical research, I used event religion to describe and interpret the participant experience in event-based settings through four dimensions: spatiotemporality, symbols, community, and inward experience. I show some characteristics of contemporary changing religiosity and spirituality through the examination of the four dimensions of experience.
An Appeal for International Solidarity in a Time of the Cold War: Retracing Indonesia’s Participation in the 1966 Tricontinental Conference
Authors: Hearman Vannessa
Published: March 2024

In January 1966, Cuban President Fidel Castro announced at the Tricontinental Conference the killing of more than 100,000 people in Indonesia and the destruction of the left movement in that country. The 1965–66 massacre of members and sympathisers of the Indonesian Communist Party (Partai Komunis Indonesia, pki) in Indonesia ushered in the authoritarian New Order regime under General Suharto, marking a realignment in Cold War politics. This article examines the battle to represent Indonesia by two competing delegations at the Tricontinental Conference and the materials left behind as traces of Cold War era social movements and tricontinentalism. The aim of the article is twofold. Drawing on archival research, oral history interviews, ego-documents, and ethnographic observations, the article consists of a partial reconstruction of the Indonesian intervention at the Tricontinental Conference, arguably the last public, international intervention by Indonesian leftists. The second part of the article examines the archives, broadly defined, used in the reconstruction and the research process itself, given the contested nature of these memories. In so doing, the article illustrates how the end of the Cold War, the rise of new media and technologies, and democratisation in Indonesia have contributed to the transmission of memories of this past to audiences in and outside of Indonesia.
Effect of Interface Form on Creep Failure and Life of Dissimilar Metal Welds Involving Nickel-Based Weld Metal and Ferritic Base Metal
Authors: Li Xiaogang , Nie Junfeng , Wang Xin , Li Kejian , Zhang Haiquan
Published: March 2024

For dissimilar metal welds (DMWs) involving nickel-based weld metal (WM) and ferritic heat resistant steel base metal (BM) in power plants, there must be an interface between WM and BM, and this interface suffers mechanical and microstructure mismatches and is often the rupture location of premature failure. In this study, a new form of WM/BM interface form, namely double Y-type interface was designed for the DMWs. Creep behaviors and life of DMWs containing double Y-type interface and conventional I-type interface were compared by finite element analysis and creep tests, and creep failure mechanisms were investigated by stress-strain analysis and microstructure characterization. By applying double Y-type interface instead of conventional I-type interface, failure location of DMW could be shifted from the WM/ferritic heat-affected zone (HAZ) interface into the ferritic HAZ or even the ferritic BM, and the failure mode change improved the creep life of DMW. The interface premature failure of I-type interface DMW was related to the coupling effect of microstructure degradation, stress and strain concentrations, and oxide notch on the WM/HAZ interface. The creep failure of double Y-type interface DMW was the result of Type IV fracture due to the creep voids and micro-cracks on fine-grain boundaries in HAZ, which was a result of the matrix softening of HAZ and lack of precipitate pinning at fine-grain boundaries. The double Y-type interface form separated the stress and strain concentrations in DMW from the WM/HAZ interface, preventing the trigger effect of oxide notch on interface failure and inhibiting the interfacial microstructure cracking. It is a novel scheme to prolong creep life and enhance reliability of DMW, by means of optimizing the interface form, decoupling the damage factors from WM/HAZ interface, and then changing the failure mechanism and shifting the failure location.
The PIRATE mnemonic: providing a structured approach in the care for intoxicated patients at the emergency department
Authors: Kraaijvanger Nicole , Raven Wouter , van Dijken Trudy , Gresnigt Femke
Published: March 2024

Background

Expertise in toxicology is essential for acute care providers, as intoxicated patients frequently present to Emergency Departments. These patients can be challenging for care providers because they often present with uncertain substance exposure and unknown dose and timing of these exposures.

Methods

The Dutch Society of Emergency Physicians has developed an mnemonic to support treating physicians in a structured approach for the management of (undifferentiated) intoxicated patients.

Results

The PIRATE mnemonic was developed, which includes the following aspects and sequence of care for the intoxicated patient: primary survey, investigation & identification, risk assessment, ADME (comprising pharmacokinetic therapeutic targets: absorption, distribution, metabolism, elimination), therapy and evaluation.

Conclusion

The toxicology section of the Dutch Society of Emergency Physicians developed the PIRATE mnemonic to provide a structured approach in the management of patients presenting with acute intoxications to Emergency Departments. It summarizes the essential steps and priorities required in the care of intoxicated patients. Further, it provides a common strategy for all specialties involved in the care of the acutely intoxicated patient, contributing to developing greater competence in poisoning management.
Efficacy of transversus abdominis plane block on postoperative nausea and vomiting: a meta-analysis of randomized controlled trial
Authors: Zeng Jinfang , Hong Aonan , Gu Zhen , Jian Jinjin , Liang Xiao
Published: March 2024

Background

Postoperative nausea and vomiting (PONV) is a common postoperative complication, and Transversus abdominis plane (TAP) block can provide effective analgesia for surgical operation. However, but there is not enough evidence to prove its advantage for nausea and vomiting. The objective of this meta-analysis was to evaluate the efficacy of TAP block on PONV.

Methods

Two independent researchers conducted searches for randomized controlled trials (RCTs) in PubMed, Embase, and Cochrane Central Register of Controlled Trials. We used Review Manager software for meta-analysis.

Results

In this meta-analysis, twenty-six trials with 1981 patients were examined. The results showed that TAP block reduced postoperative nausea (Risk Difference (RD) = -0.10, 95% confidence interval (CI): -0.15 to -0.05) compared with no TAP block. TAP block reduced the dose of fentanyl (Standardized Mean Difference (SMD) = -1.17, 95% CI: -2.07 to -0.26) and morphine (SMD = -1.12, 95% CI: -2.10 to -0.13) compared with no TAP block, when the timing of administration was before surgery (RD = -0.13, 95% CI: -0.19 to -0.07). TAP block reduced postoperative nausea when the ropivacaine dosage is ≤ 100 mg (RD = -0.13, 95% CI: -0.21 to -0.06), bupivacaine dosage ≥ 100 mg ( RD = -0.08, 95% CI: -0.13 to -0.03), and when the ropivacaine concentration was ≤ 0.375% (RD = -0.11, 95% CI: -0.18 to -0.04). TAP block significantly reduced the incidence of nausea when the types of opioid drugs in PCA is tramadol (RD = -0.13, 95% CI: -0.24 to -0.03). TAP block could reduce the VAS (SMD= -0.99, 95% CI: -1.29 to -0.70) and reduce the time of extubation (SMD = -0.71, 95% CI: -1.34 to -0.08).

Conclusion

The meta-analysis conducted in this study revealed that TAP block could reduce the incidence of PONV, and the efficacy of TAP block may be influenced by factors such as administration time, local anesthetic dosage and concentration, types of opioid drugs in PCA.
Self-management support (SMS) in primary care practice: a qualitative focus group study of care professionals’ experiences
Authors: Timmermans Lotte , Boeykens Dagje , Sirimsi Muhammed Mustafa , Van de Velde Dominique , De Vriendt Patricia , Decat Peter , Foulon Veerle , Van Hecke Ann , Vermandere Mieke , Schoenmakers Birgitte ,   the Primary Care Academy
Published: March 2024

Background

To support self-management of chronically ill persons, innovative approaches of care practice are being developed. Unfortunately, many self-management supporting interventions struggle to achieve reliable and consistent improvements at various levels (patient, provider and healthcare system level). One possible strategy to facilitate translating theory into practice, is to consider the healthcare professionals’ perspective prior to the development of new interventions. An exploration of their knowledge and opinion about barriers and facilitators is necessary before employing any self-management support (SMS) intervention. Therefore, our study aims to explore care professionals’ perspectives about SMS within the Flemish primary care setting.

Methods

This study used a qualitative study design to examine SMS in primary care setting. Five focus groups were conducted, grouped into three waves. Participants were healthcare professionals in Flanders representing different disciplines and settings. A maximum variation purposive sampling was used to recruit participants. For the data analysis, the framework of thematic networks by Attride-Stirling was applied.

Results

A total of 34 healthcare professionals participated. Three global themes related to SMS were derived from the thematic analysis: (1) Characteristics, (2) Support strategies, (3) Barriers and facilitators. SMS was characterised as a collaboration-based and person-centred approach. A variety of supporting strategies were mentioned by the focus group participants. Most strategies consisted of informing and educating patients. Complementary to individual strategies, collaborative strategies were deemed necessary to support self-management. Regarding barriers and facilitators, different patient-related factors were identified. Additionally, competencies of healthcare providers and external factors seem to hinder the implementation of SMS in practice.

Conclusions

This focus group study highlights the importance of a collaborative, person-centred approach to SMS in the context of chronic diseases. Our findings point to the need for interventions that raise awareness and address barriers associated with SMS. Since generic SMS does not exist, the road to success is a growth process in which support must be adapted to the individual patient.
The Intersectoral Coordination Unit for the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) cohort study
Authors: Wülfrath Hauke S. , Schrumpf Thorben , von Samson-Himmelstjerna Friedrich A. , Voran Jakob , Zhang Yao , Esser Grit , Thomsen Sarah-Yasmin , Messtorff Maja L. , Riebeling Theresa , Kakavand Nassim , Schmitt Roland , Schulte Kevin , Kolbrink Benedikt
Published: March 2024

Background

Peritoneal dialysis (PD) remains underutilised in Germany, prompting the initiation of the Sustainable Intensification of Peritoneal Dialysis in Schleswig–Holstein (SKIP-SH) project. The SKIP-SH cohort study aims to demonstrate the presumed benefits of PD, including enhanced quality of life and reduced healthcare personnel requirements, and to generate data to strengthen the use of PD.

Methods

The prospective SKIP-SH cohort study recruits patients with advanced chronic kidney disease (CKD) and their caregivers. Comprehensive data, including demographic information, medical history, clinical course, laboratory data, and quality-of-life assessments, are collected. Additionally, biomaterials will be obtained.

Primary study objectives are documenting the clinical course and complications, time on therapy for new dialysis patients, reasons influencing treatment modality choices, circumstances at the initiation of dialysis, and quality of life for patients with CKD and their caregivers. The collected biomaterials will serve as a basis for further translational research. Secondary objectives include identifying factors impacting disease-related quality of life, clinical complications, and therapy dropout, estimating ecological footprints, and evaluating healthcare costs and labour time for initiating and sustaining PD treatment.

Discussion

PD is notably underutilised in Germany. The current therapy approach for advanced CKD often lacks emphasis on patient-focused care and quality-of-life considerations. Furthermore, adequate explorative research programs to improve our knowledge of mechanisms leading to disease progression and therapy failure in PD patients are scarce.

The overarching goal of the SKIP-SH cohort study is to address the notably low PD prevalence in Germany whilst advocating for a shift towards patient-focused care, quality-of-life considerations, and robust translational research.

Trial registration

This study was registered with the German trial registry (Deutsches Register klinischer Studien) on November 7, 2023, under trial number DRKS00032983.
Convolutional neural network applied to preoperative venous-phase CT images predicts risk category in patients with gastric gastrointestinal stromal tumors
Authors: Wang Jian , Shao Meihua , Hu Hongjie , Xiao Wenbo , Cheng Guohua , Yang Guangzhao , Ji Hongli , Yu Susu , Wan Jie , Xie Zongyu , Xu Maosheng
Published: March 2024

Objective

The risk category of gastric gastrointestinal stromal tumors (GISTs) are closely related to the surgical method, the scope of resection, and the need for preoperative chemotherapy. We aimed to develop and validate convolutional neural network (CNN) models based on preoperative venous-phase CT images to predict the risk category of gastric GISTs.

Method

A total of 425 patients pathologically diagnosed with gastric GISTs at the authors’ medical centers between January 2012 and July 2021 were split into a training set (154, 84, and 59 with very low/low, intermediate, and high-risk, respectively) and a validation set (67, 35, and 26, respectively). Three CNN models were constructed by obtaining the upper and lower 1, 4, and 7 layers of the maximum tumour mask slice based on venous-phase CT Images and models of CNN_layer3, CNN_layer9, and CNN_layer15 established, respectively. The area under the receiver operating characteristics curve (AUROC) and the Obuchowski index were calculated to compare the diagnostic performance of the CNN models.

Results

In the validation set, CNN_layer3, CNN_layer9, and CNN_layer15 had AUROCs of 0.89, 0.90, and 0.90, respectively, for low-risk gastric GISTs; 0.82, 0.83, and 0.83 for intermediate-risk gastric GISTs; and 0.86, 0.86, and 0.85 for high-risk gastric GISTs. In the validation dataset, CNN_layer3 (Obuchowski index, 0.871) provided similar performance than CNN_layer9 and CNN_layer15 (Obuchowski index, 0.875 and 0.873, respectively) in prediction of the gastric GIST risk category (All P >.05).

Conclusions

The CNN based on preoperative venous-phase CT images showed good performance for predicting the risk category of gastric GISTs.
A collaboration team to build social service partnerships within a safety-net health system
Authors: Carson Savanna L. , Cameron Francesca , Lee Diamond , Zúñiga Diana , Poole Kelli , Jones Adjoa , Herman Cristina , Ramirez Mayra , Harlow Simone , Johnson Jeannette , Agonafer Etsemaye P. , Hong Clemens S. , Brown Arleen F.
Published: March 2024

Background

To facilitate safety-net healthcare system partnerships with community social service providers, the Los Angeles County Department of Health Services (LAC DHS) created a new collaboration team to spur cross-agency social and medical referral networks and engage communities affected by health disparities as part of a Sect. 1115 Medicaid waiver in Los Angeles County entitled Whole Person Care-Los Angeles (WPC-LA).

Methods

This observational research reviews three years of collaboration team implementation (2018–2020) through Medicaid-reportable engagement reports, a collaboration team qualitative survey on challenges, facilitators, and recommendations for community engagement. Member reflections for survey findings were conducted with the collaboration team and LAC DHS WPC-LA leadership.

Results

Collaboration team Medicaid engagement reports (n = 144) reported > 2,700 events, reaching > 70,000 individuals through cross-agency and community-partnered meetings. The collaboration team survey (n = 9) and member reflection sessions portrayed engagement processes through outreach, service assessments, and facilitation of service partnerships. The collaboration team facilitated community engagement processes through countywide workgroups on justice-system diversion and African American infant and maternal health. Recommendations for future safety net health system engagement processes included assessing health system readiness for community engagement and identifying strategies to build mutually beneficial social service partnerships.

Conclusions

A dedicated collaboration team allowed for bi-directional knowledge exchange between county services, populations with lived experience, and social services, identifying service gaps and recommendations. Engagement with communities affected by health disparities resulted in health system policy recommendations and changes.
Outcome in methadone maintenance treatment of immigrants from the former Union of Soviet Socialist Republics
Authors: Noya Ayali , Anat Sason , Shaul Schreiber , Miriam Adelson , Einat Peles
Published: March 2024

Context

Immigrants from the former Union of Soviet Socialist Republics (USSR) are more prevalent in Methadone maintenance treatment (MMT) in Israel than their percentage in the general population.

Aims

To compare their characteristics and outcomes to those of Israeli-born and other immigrant patients.

Methods

Retention and survival since admission (June/1993–Dec/2022) until leaving treatment (for retention), or at the end of follow-up were analyzed. Vital data was taken from a national registry. Predictors were estimated using Kaplan–Meier and Cox regression models.

Results

The USSR patients (N = 262) compared with other immigrants (N = 132) and Israeli-born (N = 696) were more educated (≥ 12y) (p < 0.001), admitted to MMT at a younger age (p < 0.001), following a shorter duration of opioid usage (p < 0.001). More of them ever injected drugs (p < 0.001) and ever drank alcohol (p < 0.001). One-year retention was comparable (77.2% vs. 75.6% and 72%, p = 0.2) as did opioid discontinuation in those who stayed (p = 0.2). Former USSR patients had longer cumulative retention of their first admission (p = 0.05) with comparable overall retention since first admission, and survival, although the age of death was younger. Specific origin within the former USSR found immigrants from the Russian Federation with the best outcome, and those from Ukraine as having high HIV seropositive and shorter retention.

Conclusions

Despite several characteristics known to be associated with poor outcomes, former USSR immigrants showed better adherence to MMT, reflected by their longer cumulative retention in their first admission, lower rate of readmissions, and a comparable survival and overall retention in treatment. An in depth study is needed in order to understand why they decease at a younger age.
Stakeholders’ perceptions of hydrogen and reflections on energy transition governance
Authors: Parente Cristina , Teixeira Francisca , Cerdeira Jorge
Published: March 2024

Background

There is a race to innovate, develop or create hydrogen production technologies to accelerate energy transition and create a hydrogen economy. Acceptance has been used in social science literature as a lens through which to anticipate possible challenges surrounding hydrogen technologies. However, very few studies problematize perceptions and focus on the production of hydrogen. Hence, this study aims to bridge these theoretical and empirical gaps using a mixed-method approach based on semi-structured interviews (n = 7) and a questionnaire survey (n = 73) to understand stakeholders’ perceptions of hydrogen production sources through a social construction of technology lens.

Results

The findings suggest a tendency to favor hydrogen produced from renewable sources and to reject hydrogen produced from non-renewable sources. All the examined groups conform to this pattern. Their perceptions are based on prior knowledge of hydrogen technologies, with participants seeking information from specialized sources or from activities promoted by their organizations. Participants anticipate that hydrogen will be generated primarily through renewable energy sources and utilized where direct electrification is unfeasible. In addition, they envisage that the hydrogen economy will enhance energy democracy through representative participation in decision-making. Nevertheless, it is acknowledged that the topic is limited to certain social groups and kept away from the public eye. Furthermore, unlike the benefits, the perception of risk appears to have no impact on perceptions’ construction. High confidence in science appears to minimize the recognition of potential risks and bolster the recognition of potential benefits. There is, however, a lot of uncertainty about the possible real impacts of the hydrogen economy.

Conclusions

There appears to be a collective perspective on hydrogen production sources, indicating the existence of social representations. Nevertheless, group attitudes and backing towards hydrogen vary. The participants identify hydrogen as a matter that remained unnoticed for over a decade, despite its prominent position in the policies and economic approaches of numerous countries. The topic has been relegated to third parties. This exclusion of civil society from decision-making may justify the NGO group's critical stance towards hydrogen. Moreover, it suggests that energy democracy, which is based on information dissemination and participation, is not being achieved.
The feasibility of a novel 3D-Printed patient specific cutting guide for extended trochanteric osteotomies
Authors: Bergemann Reza , Roytman Gregory R. , Ani Lidia , Ramji Alim F. , Leslie Michael P. , Tommasini Steven M. , Wiznia Daniel H.
Published: March 2024

Background

The extended trochanteric osteotomy (ETO) is a surgical technique utilized to expose the intramedullary canal of the proximal femur, protect the soft tissues and promote reliable healing. However, imprecise execution of the osteotomy can lead to fracture, soft tissue injury, non-union, and unnecessary morbidity. We developed a technique to create patient specific, 3D-printed cutting guides to aid in accurate positioning of the ETO and improve osteotomy quality and outcomes.

Methods

Patient specific cutting guides were created based on CT scans using Synopysis Simpleware ScanIP and Solidworks. Custom 3D printed cutting guides were tested on synthetic femurs with foam cortical shells and on cadaveric femurs. To confirm accuracy of the osteotomies, dimensions of the performed osteotomies were compared to the virtually planned osteotomies.

Results

Use of the patient specific ETO cutting guides resulted in successful osteotomies, exposing the femoral canal and the femoral stem both in synthetic sawbone and cadaveric testing. In cadaveric testing, the guides allowed for osteotomies without fracture and cuts made using the guide were accurate within 6 percent error from the virtually planned osteotomy.

Conclusion

The 3D-printed patient specific cutting guides used to aid in ETOs proved to be accurate. Through the iterative development of cutting guides, we found that a simple design was key to a reliable and accurate guide. While future clinical trials in human subjects are needed, we believe our custom 3D printed cutting guide design to be effective at aiding in performing ETOs for revision total hip arthroplasty surgeries.
Correction to: Study of serum sclerostin levels and its role in vascular calcification in patients with chronic kidney disease
Authors: Elarbagy Ahmed R. , Yassein Yassein S. , Emara Mahmoud M. , Sonbol Ahmed A. , Elzorkany Khaled M. A. , Sharaf El Deen Amera A.
Published: March 2024

An amendment to this paper has been published and can be accessed via the original article.
Phase II Trial of nab-Sirolimus in Patients With Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT): Long-Term Efficacy and Safety Update
Authors: Wagner Andrew J. , Ravi Vinod , Riedel Richard F. , Ganjoo Kristen , Van Tine Brian A. , Chugh Rashmi , Cranmer Lee , Gordon Erlinda M. , Hornick Jason L. , Du Heng , Ding Li , Schmid Anita N. , Navarro Willis H. , Kwiatkowski David J. , Dickson Mark A.
Published: March 2024

Clinical trials frequently include multiple end points that mature at different times. The initial report, typically based on the primary end point, may be published when key planned co-primary or secondary analyses are not yet available. Clinical Trial Updates provide an opportunity to disseminate additional results from studies, published in JCO or elsewhere, for which the primary end point has already been reported.

nab-Sirolimus is approved in the United States for the treatment of metastatic or locally advanced malignant perivascular epithelioid cell tumor (PEComa) on the basis of the primary analysis results of the phase II Advanced Malignant Perivascular Epithelioid Cell Tumors (AMPECT) trial (ClinicalTrials.gov identifier: NCT02494570 ). Results from the primary analysis were previously published; however, the median duration of response (mDOR) had not been reached at that time. Here, 3 years after the primary analysis, we report final efficacy and safety data (data cutoff: April 29, 2022). At study completion, the confirmed overall response rate (by independent radiologist review using RECIST v1.1) was 38.7% (95% CI, 21.8 to 57.8), with an additional converted confirmed complete response (n = 2). Median progression-free survival remained the same at 10.6 months (95% CI, 5.5 to 41.2). The mDOR was reached at 39.7 months (95% CI, 6.5 to not reached [NR]), and the median overall survival at completion was 53.1 months (95% CI, 22.2 to NR). The most common treatment-related adverse events (TRAEs) were stomatitis (82.4%) and fatigue and rash (each 61.8%). No new or unexpected adverse events occurred, and no grade ≥4 TRAEs were reported. These results highlight the long-term clinical benefit of nab-sirolimus in patients with advanced malignant PEComa, with a DOR of >3 years.
Co-creation of the Digital Democracy and Data Commons Manifesto: alternative sociotechnical visions of data
Authors: Senabre Hidalgo Enric , Calleja Antonio , Espelt Ricard , Suárez Gonzalo Sara , Fuster Morell Mayo , Belsunces Andreu
Published: March 2024

Amid public concern surrounding the proprietary and exploitative use of personal data by corporations and public institutions, and its consequences from a sociotechnical perspective, narratives around digital commons have recently emerged, framing potential alternatives. This paper presents the results of an experimental approach, methodology, and process, through which two main questions are addressed. Firstly, how to articulate co-creation dynamics for the structured and participatory elaboration of the Digital Democracy and Data Commons Manifesto, following principles of openness, diversity, and inclusivity. Secondly, how the manifesto, as a narrative and discursive artefact, can follow and conclude a wider process of sociotechnical discussion and positioning about data commons. Our approach is based on participatory design methods, more concretely on a collaborative writing sprint, to co-create a manifesto on alternatives to current datafication, digital inequalities, and lack of citizen control over personal data. On the one hand, we describe the process of implementing a sprint approach for collaboratively writing a topic-specific manifesto, in the context of the broader EU project DECODE (Decentralised Citizen Owned Data Ecosystems). On the other hand, we present and analyse the main results from the content structure of the manifesto over its initial and final versions, which moved progressively as a cohesive text away from a scholarly and policy-oriented tone.
The genome sequence of the Black Lace-weaver spider, Amaurobius ferox (Walckenaer, 1830)
Authors: Henriques Sérgio ,   Natural History Museum Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: March 2024

We present a genome assembly from an individual female Amaurobius ferox (the Black Lace-weaver; Arthropoda; Arachnida; Araneae; Amaurobiidae). The genome sequence is 3,564.8 megabases in span. Most of the assembly is scaffolded into 23 chromosomal pseudomolecules, including the X1, X2 and X3 sex chromosomes. The mitochondrial genome has also been assembled and is 14.24 kilobases in length.
Iron Age Metalworking at Masafi-1? A Reconsideration of the Metal Hoards Discovered in the Collective Buildings
Authors: Benoist Anne , Hamel Aurélien , Le Carlier Cécile , Degli Esposti Michele , Goy Julie
Published: March 2024

Excavations in a series of superimposed Iron Age II collective buildings located at Masafi (Fujairah, UAE) by the French Archaeological Mission in the UAE allowed the discovery of two deposits of copper-base metal items buried in two jars. Copper smelting played a major role in the economy and the society of the region and consistent evidence suggest that it also had a symbolic importance. A summary of the archaeometallurgical study of the items discovered at Masafi is presented here and the context of the two deposits is discussed, in order to reconstruct the nature of these two hoards and the function of the buildings.
Katecheza szkolna a poczucie tożsamości religijnej ucznia klasy pierwszej – studium przypadku
Authors: Lisowska Kinga
Published: March 2024

W świecie pełnym pluralizmu kulturowego dziecko staje przed trudnym zadaniem wyboru różnorodnych wartości, norm, zachowań czy też rytuałów. Wzrasta w kulturowej strukturze rodziny, ale także w środowiskach szkolnych i rówieśniczych, reprezentujących elementy kultury moralnej ukierunkowanej na wyznawanie określonej wiary. Podejmowanie wyborów to poszukiwanie identyfikacji, poczucia wspólnotowego, przynależności, a jednocześnie odmienności od innych. Dziecko od początku swojego życia poszukuje przynależności do danej grupy społecznej. Dokonuje tego poprzez spotkanie z różnymi przestrzeniami kulturowymi w procesie dorastania. Dzięki temu kształtuje swoją tożsamość społeczną, a wraz z nią tożsamość religijną, która może ulegać modyfikacji w trakcie jego rozwoju i wychowania w środowisku rodzinnym oraz szkolnym. W artykule przedstawiono studium przypadku dziecka 7-letniego, które po doświadczeniu katechezy szkolnej charakteryzuje się większą identyfikacją z wiarą katolicką niż przed okresem rozpoczęcia edukacji. Na podstawie przeprowadzonych badań jakościowych stwierdzono funkcjonowanie elementów życia religijnego dziecka, które nie pochodzą z jego środowiska rodzinnego, ale zostały ukształtowane w rezultacie doświadczania religii podczas katechezy w szkole.
The Absence of Young Carers in the Polish Legislation
Authors: Chojnacka Barbara
Published: March 2024

The article analyses the legal acts dedicated to child and family issues in the context of the issue of young carers which is widely addressed internationally. The questions posed relate primarily to the issue of children’s rights, their protection, the topic of care and parental responsibility, as well as the problems experienced by the family. The article attempts to demonstrate an important research and legislative gap in relation to the situation of children undertaking caring tasks within the family. The analysis reveals the unidirectional nature of guardianship as perceived in Polish legislation. No provision is made for other mechanisms that may take place within the family, making young carers in this situation unnoticeable.
Sens życia w świadomości uwięzionych rodziców. Logoterapia a samowychowanie
Authors: Badowska-Hodyr Monika
Published: March 2024

Artykuł dotyczy poszukiwań związanych z odbudową sensu życia przez rodziców odbywających karę pozbawienia wolności. Wydaje się, co potwierdzają przeprowadzone badania, że może to być możliwe poprzez realizację wartości. W warunkach więziennych, gdzie trudno o stabilność emocjonalną i przeżywanie poczucia osamotnienia, pewne światło rzuca koncepcja logoterapii oraz rozwoju zdolności poznawczych i wolitywnych. Chodzi zatem o samowychowanie do budowania sensu życia, w którym trzeba odnaleźć sens w codzienności i nabyć umiejętność kształtowania swojego sposobu bycia.
The Tato.Net Initiative – A Program Developed by the Cyryl and Metody Foundation in Support of Contemporary Fatherhood
Authors: Kaszubska-Dziergas Patrycja
Published: March 2024

This study aims to present the operation of the Tato.Net Initiative [Dad.Net] implemented by the Cyryl and Metody Foundation (hereafter referred to as the Foundation). The programme was launched in 2004 to promote conscious and responsible fatherhood among contemporary men through self-education and self-formation amidst a crisis in masculinity, brought on by modern civilisation, and its negative consequences with regard to fatherhood. The Tato.Net programme implements initiatives and projects to strengthen families through the empowering presence of the father, both in the physical and spiritual sense. The programme also engages in cooperation with social organisations and institutions that similarly advance the culture of responsible fatherhood. All actions undertaken by Tato.Net reflect the idea of fatherhood, with the project itself founded on two primary values: the empowerment of a family by the presence of the father and the promotion of a culture of responsible fatherhood. The paper presents different projects executed by the Foundation in a few countries.