bluuebunny/crossref_metadata_2025 huggingface dataset:
Development and Evaluation of a Design Framework for Preparing Infographic Forms for Scholarly Publications
Authors: Orhan Daha , Yıldırım Serkan
Published: June 2024

The propeller jet flow caused to significant erosion and sedimentation near port structures, in front of quay walls, and around pile structures. Additionally, shallow water depths increase the amount of erosion caused by the propeller jet. If these problems are not considered during the design phase, serious erosion at the foundation of port structures and consequent significant stability issues may occur. In this study, the effect of erosion under twin propeller jet influence was investigated by examining the distance between propellers and the seabed, propeller propeller speed, and the distance between propellers, and the results were compared. It was found that as the propeller speed increases, the maximum erosion increases, as the distance between propellers increases, the maximum erosion decreases, and as the distance between the propeller and the seabed increases, the maximum erosion decreases. The obtained maximum erosion results were found to be consistent with the literature.
Yapı ile Sınırlandırılmamış Çift Pervane Jet Etkisinde Oyulmanın Deneysel Olarak Araştırılması
Authors: Suljevic Amina , Kesgin Erdal
Published: June 2024

Pervane jet akımı, liman yapılarının yakınlarında, rıhtım duvarları önünde ve kazıklı yapıların etrafında ciddi oyulma ve birikmelere neden olmaktadır. Ayrıca sığ su derinlikleri de pervane jeti oyulma miktarını artırmaktadır. Bu problemler projelendirme sırasında dikkate alınmadığı takdirde liman yapılarının temelinde ciddi oyulmalar ve buna bağlı önemli stabilite sorunları meydana getirmektedir. Bu çalışmada çift pervane jet etkisindeki oyulmaya, pervaneler ile taban arasındaki mesafe, pervane dönüş hızı ve pervaneler arası mesafenin etkisi incelenmiş ve sonuçlar karşılaştırılmıştır. Çalışma sonucunda elde edilen verilerden yola çıkarak dönüş hızı arttığında maksimum oyulmanın arttığı, pervaneler arası mesafe arttığında maksimum oyulmanın azaldığı ve pervane ile taban arasındaki mesafe arttığında maksimum oyulmanın azaldığı tespit edilmiştir. Elde edilen maksimum oyulma sonuçlarının literatür ile uyumlu olduğu tespit edilmiştir.
Teachers’ Job Satisfaction and School Academic Achievement
Authors:   Department of Education, Division of Leyte, Philippines, Dalton Wilbur , Arpon Allen ,   College of Graduate Studies, Palompon Institute of Technology, Palompon, Leyte, Philippines
Published: June 2024

The study analyzed the relationship between teachers’ job satisfaction and academic achievement in the elementary schools in Leyte Division, Philippines. The study adopted a descriptive research design. It utilized the job satisfaction survey questionnaire and the National Achievement Test results. The statistical tools included the weighted mean and Pearson correlation coefficient. It was revealed that teachers were satisfied with their job assignments. Whereas, academic achievement showed an average mean percentage score (MPS), indicating an achievement that is moving towards mastery. Moreover, it was disclosed that there was no significant relationship between teachers’ job satisfaction and school academic achievement. To enhance the level of teachers’ job satisfaction and further improve school academic achievement, school administrators may consider strategic initiatives that support teachers’ career development. Thus, it is suggested that school heads should look into the personal and professional well-being of teachers. Future studies, including additional variables such as teachers’ information and communication technology (ICT) literacy skills and ICT facilities, should correlate it with school achievement.
Principals’ Management Skills and School Academic Achievement
Authors:   Department of Education, Division of Leyte, Philippines, Dalton Wilbur , Arpon Allen ,   College of Graduate Studies, Palompon Institute of Technology, Palompon, Leyte, Philippines
Published: June 2024

School management skills are seen as the dominant indicating factors for the success of the school, such as academic achievement. This study examines the relationship between management skills and academic achievement in the respondents’ schools in Leyte Division, utilizing a descriptive research design. Questionnaires and documentary analysis were used in gathering the relevant data. The school principals with at least three years of experience were involved in the study. The weighted mean and Pearson correlation coefficient were used in the data analysis. Results revealed that the principals had very high management skills in technical, conceptual, human relations, administrative and supervisory, resource generation and fiscal management, and networking and linkages. Overall, the school principals possess the necessary management skills to govern the school. On the other hand, the academic achievement of the selected schools was categorized as moving towards mastery. This indicates that the schools had their best practices in place. Moreover, findings showed that there is no significant relationship between management skills and school academic achievement. For the continual improvement of quality education, future studies, including additional variables such as schools’ ICT facilities, may be correlated with school achievement.
Smart Educational Resource Management: A QR Code-Enabled System with Notification and Alerting Capabilities
Authors:   Fidel Zarceno National High School, Carles, Iloilo, Western Visayas, Philippines, Teves Lyrene Lamera
Published: June 2024

Effective management of educational resources is crucial for ensuring the quality of learning outcomes. However, traditional systems often rely on manual processes, leading to inefficiencies, errors, and delays. This paper presents a novel QR Code-Enabled Educational Resource Management System that leverages Quick Response (QR) codes to streamline these processes. The proposed system uses QR codes to track the availability and location of resources such as textbooks and equipment. Students and teachers can scan these codes with mobile devices to access relevant information, including resource availability, location, and usage history. Additionally, the system features notifications and alerting capabilities that remind users when resources are due or inform them of changes in availability. The system was evaluated using the ISO/IEC 25010 Model Quality Characteristics Framework, which includes functional suitability, performance efficiency, compatibility, usability, reliability, portability, and maintainability. Results indicate high levels of quality in use, with excellent performance efficiency, security, compatibility, reliability, and maintainability. This study demonstrates the potential of the QR Code-Enabled Educational Resource Management System to enhance the effectiveness and efficiency of educational institutions. The system's notification and alerting capabilities can further improve student engagement and motivation by providing timely reminders and updates on resource availability.
Enrollment Appraisal Using Rule-Based Decision Support System
Authors:   College of Computer Studies, University of Antique, Sibalom, Antique, Philippines, Villaruz Robelia Joy , Diamante Renante ,   College of Information Communication Technology, Iloilo State University of Fisheries Science and Technology, Barotac Nuevo, Iloilo, Philippines
Published: June 2024

This study explores the development and evaluation of a web-based enrollment appraisal system utilizing a rule-based decision support system for universities and colleges. Designed for the context of Antique, Philippines, the system leverages a two-tier architecture for efficient processing and secure data management. A user-friendly interface guides applicants through the enrollment process, while a secure server and rule-based engine analyze data against pre-defined eligibility criteria. The Rapid Application Development (RAD) methodology ensured a user-centered design with iterative development cycles incorporating user feedback. Evaluations using McCall's Software Quality Standard and the International Organization for Standardization and International Electrotechnical Commission (ISO/IEC) 25010 standard revealed the system's strengths in technical aspects (security, usability) and overall functionality. User feedback highlighted areas for improvement in interface design, clarity, and user perceptions of data security. The study concludes that the system offers a promising approach for more efficient and transparent enrollment processes. By addressing the feedback received, the system can be further enhanced to improve the user experience and build trust among applicants.
Real-time Water Level Monitoring System in Oriental Mindoro Using Neural Networks
Authors:   AMA University, Quezon City, Manila, Philippines / Mindoro State University, Victoria, Oriental Mindoro, Philippines, Luzon-German Christine , Evangelista Ryan ,   School of Graduate Studies, Sulu State College, Capitol Site, Bangkal, Patikul, Sulu, Philippines
Published: June 2024

Oriental Mindoro faced an environmental problem that was caused by the massive rains from the highlands of the city. The lowlands cannot prepare for the upcoming floods with manual prediction and based on instinct. A water monitoring level was setup in three different rivers that end the streams in the city of Oriental Mindoro. This study focuses on the development of a real-time water level monitoring system to help with disaster preparedness in Oriental Mindoro. The dataset collected was from the provincial government, which shows the diversity of data that can be correlated to predict if a flash flood will occur. The dataset was tested using different algorithms such as Gradient Boosted Tree, SVM, Decision Tree, and Neural Networks. The prediction of the Neural Network model’s accuracy is 98.61%, which is 0.6 percentage points higher than the Gradient Boosted Tree and more than the rest of the algorithms.
Enhancing Performance of Public-Private Partnership Projects: Data Management and Capacity Building of Standard Gauge Railway
Authors: Kaburu Sam , Abuya Isaac
Published: July 2024

This study assessed the impact of data management and capacity building on the performance of the Standard Gauge Railway (SGR) project in Kenya, specifically within the context of monitoring and evaluation (M&E) practices in public-private partnership (PPP) frameworks. Anchored in the tenets of the Principal-Agent Theory, Institutional Theory, and Transaction Cost Economics Theory, this research employs a survey-based approach, drawing insights from 55 SGR project employees. In exploring the influence of data management, the findings illuminate its significant correlation with the orchestration and advancement of the SGR project. Additionally, the study underscores the positive repercussions of capacity-building initiatives on enhancing the project’s performance metrics. Notably, participants exhibited a consensus regarding the efficacy of these programs in augmenting the skills and knowledge base of the project team and stakeholders. The study accentuates the imperative for a comprehensive review aimed at fortifying the accuracy and security of project data. It recommends a strategic emphasis on initiatives enhancing data reliability and security within the SGR project’s framework. These insights contribute crucial perspectives on the pivotal roles of data management and capacity building, specifically underscoring their influence on the SGR project in Kenya.
Hubungan Efikasi Diri Dengan Kepatuhan Diet Rendah Garam Pada Lansia Hipertensi Di Pesisir Pantai Puskesmas Pakuhaji
Authors: Deswita Reny
Published: June 2024

Latar Belakang: Hipertensi merupakan faktor risiko kematian nomor satu secara global, mempengaruhi lebih dari satu miliar orang. Hipertensi tidak menimbulkan gejala apapun sehingga disebut sebagai silent killer. Perubahan hemodinamik mekanis, kekakuan arteri, disregulasi neurohormonal dan otonom serta penurunan fungsi ginjal meningkatkan risiko hipertensi pada lansia. Hipertensi dapat dikendalikan dengan kepatuhan minum obat. Efikasi diri merupakan faktor yang berperan penting dalam kepatuhan pengobatan. Tujuan: mengetahui  hubungan efikasi diri dengan kepatuhan diet rendah garam pada lansia hipertensi di Wilayah Pesisir Pantai Puskesmas Pakuhaji. Metode: Penelitian kuantitatif dengan design cross sectional. Sebanyak 84 responden ditarik dengan teknik purposive sampling. Kriteria inklusi: usia responden ≥ 60; anggota prolanis di puskesmas pakuhaji; mampu berkomunikasi, membaca dan menulis dengan baik. Waktu pelaksanaan penelitian Maret s.d Juli 2023. Analisis data dengan menggunakan Spearman Rank. Hasil: Terdapat hubungan yang signifikan antara efikasi diri dengan kepatuhan diet rendah garam (p value 0,000), dengan korelasi yang kuat dan positif antara efikasi diri dengan kepatuhan diet rendah garam (0,634). Kesimpulan: Semakin tinggi efikasi diri  lansia maka akan semakin tinggi pula kepatuhan diet rendah garam.
The Influence of Mental Health Education on Adolescents Knowledge in Preventing Bullying Based on Behavioristic Theory
Authors: A. Sri Ulfi Nofriati
Published: June 2024

Adolescence is a period that is vulnerable to experiencing negative behavior in friendships, especially at school. One of the bad behaviors that often occurs during adolescence is bullying. Bullying is a violent activity that has a negative impact, especially on mental health. To overcome the problem of bullying among teenagers, education is needed about the impact of bullying on mental health, using a behaviorist theory approach. Therefore, this research aims to determine the effect of mental health education on teenagers' knowledge of preventing bullying using a behaviorist theory approach. This research uses quantitative methods with a quasi-experimental approach and a one-group pretest-posttest design. The results of this study show that there is a significant influence of mental health educational interventions on teenagers' knowledge of preventing bullying.
A Weighted multi-objective evolutionary algorithm optimization
Authors: Sinha Amit Kumar
Published: June 2024

Weight Based Genetic Algorithms (WBGA) have a computational efficacy and non-cumbersome for multi-objective optimization. The solutions obtained in the converged region do not always produce maximum optimization for all the objective functions simultaneously. But, the combination of the solutions from different iteration may yield optimized values for all the objective functions to a satisfactory level.  The paper attempts to find a method which keeps the simplicity and computational efficiency of WBGA intact, but at the same time counters the problem of inferior pareto-optimal solutions. This is done by finding such a combinational set of solutions which yields strong values for all the objectives. The paper proposes neutrosophic logic (NL) as a postprocessor to the outcome of the WBGA. The NL assigns a percentage of truth, false and indeterminant value to the obtained solutions. The proposed postprocessor operation has been demonstrated with hand calculations on a test problem, and a complex practical example. The results obtained as compared to WBGA show the emergence of a superior solution-set and reaches in close agreement with NSGA-II, while maintaining the computational efficiency.
Emergent energy storage sector in the developing world: A technological and strategic perspective
Authors: Shaligram Apoorv , Sen Uttam Kumar
Published: June 2024

With the focus on clean energy, efficient devices and electric mobility solutions, the market for energy storage is on the rise in the developing world. In this paper, the requirements of Indian energy storage market have been highlighted based on the different categories of applications. An in-depth study of the utilitarian advantages and disadvantages of different energy storage technologies has been conducted. Based on this, suitable energy storage technologies for different applications have been suggested. We have further delved into the elements required for all the feasible energy storage technologies. The availability of strategic reserves of these minerals in India have been examined. We have calculated the elemental requirements for different technologies, normalized to their energy storage capacity. Finally, we have suggested technologies to achieve a best-case scenario for the Indian energy storage sector from technological as well as a strategic viewpoint, minimizing the import dependency of raw materials.
Evaluating Tax Compliance Cost on SME Performance in Vietnam
Authors: Trang Dao Thi Dai
Published: June 2024

This study focuses on the burden of tax compliance of Small and Medium Enterprises (SMEs) in Vietnam which is a vital component of Vietnam economy, accounted for 45% GDP and 31% of total State budget revenue, attract more than 5 million employees. Based on a quick survey on the compliance cost and their impact on the performance of Vietnamese SMEs, we try to make a contribution not only for researchers but also for legal and taxation system to improve the transparency of accounting information system, internal control of the firms. The result of our study suggests that among those tax compliance cost in the SMEs: external, internal tax cost, and miscellaneous tax cost, the internal tax cost accounted for the major expenses in tax compliance in Vietnam, after that the miscellaneous tax cost also a significant cost for complying with tax regulation. External costs were evaluated at low percentage compared to the left component of tax procedure cost. With this result, study have shown some tax compliance cost type making burden for SME as well as evaluating issue in tax system in Vietnam.
Modelling of Whispering Gallery Mode Resonators for Dielectric Measurement Applications
Authors: Thakur Srinesh , Paul Dipra , Oruganti Sai Kiran , Karras Dimitrios A
Published: June 2024

This study presents a method for measuring the permittivity of dielectric materials using a whispering gallery mode ring resonator. By detecting changes in coupling resulting from variations in resonant frequency caused by alterations in dielectric constant, the method offers a reliable means of characterizing dielectric properties. Operating within the 5-6 GHz frequency range, the presented resonator design leverages printed circuit board (PCB) technology and FR4 substrate material for cost-effective fabrication and flexibility in design. Through comprehensive electromagnetic simulations using ANSYS HFSS software, the study optimizes resonator parameters to enhance sensitivity and effectiveness for various applications. Experimental validation demonstrates exceptional coupling efficiency and sensitivity, underscoring the potential of whispering gallery mode resonators for environmental monitoring, chemical sensing, telecommunications, and biomedical diagnostics. This research contributes to advancing sensing technology, offering valuable insights into the design and optimization of whispering gallery mode resonators for practical use. Further exploration is warranted to fully realize their potential across diverse applications and operating conditions.
Diagnosing Brain Tumors: An Artificial Intelligence Modeling Approach
Authors: Maurmo Danilo , Ruga Tommaso , Zumpano Ester , Vocaturo Eugenio
Published: June 2024

Brain tumour diagnosis poses significant challenges due to the complexity and heterogeneity of tumour characteristics. This study introduces an innovative deep-learning approach that leverages the complementary strengths of weighted magnetic resonance imaging and advanced deep-learning techniques to enhance the accuracy and reliability of brain tumour diagnosis. Historically, diverse methodologies have been employed, often centring on categorizing imaging modalities into binary distinctions, either cancerous versus non-cancerous images or discerning between benign and malignant tumours. In contrast, this study aims to classify multi-class malignant tumours into their specific categories with optimal precision. The proposed research centres on the differentiation of meningioma, glioma, and pituitary adenoma brain tumours, representing the three primary types of malignant brain tumours, along with non-tumorous MRI scans. This study employs a Convolutional Neural Network (CNN) and a Variational Autoencoder for the detection of brain tumours in Magnetic Resonance Imaging (MRI) images. Hyperparameter tuning for the CNN is achieved through a Grid search. The highest-performing model exhibits an accuracy of 95.25%, the other model reaches a peak accuracy of almost 100% in diagnosing cases without tumours.
الطموح وعلاقته بالتحصيل الدراسي لدى الأطفال الأيتام ونظرائهم في مدارس محافظات فلسطين الجنوبية
Authors: أبو رحمة محمد , أبو ليلة حسين , القططي محمد , جرادة صفاء
Published: June 2024

هدفت الدراسة إلى التعرف إلى درجة الطموح وعلاقته بالتحصيل الدراسي لدى الأطفال الأيتام ونظرائهم في مدارس محافظات فلسطين الجنوبية، واستخدم الباحثون المنهج الوصفي التحليلي، وتكونت عينة الدراسة من (142) طفلاً وطفلة من الطلبة الأيتام وغير الأيتام، واستخدم الباحثون مقياس الشرافي (2013) للطموح بعد تعديله ليناسب الدراسة ومن أهم نتائج الدراسة أن الدرجة الكلية لمستوى الطموح لدى الأطفال الأيتام هي (69.08%) ولنظرائهم (81.71%) ،وأظهرت أن الدرجة الكلية لمستوى التحصيل الدراسي للطلبة غير الأيتام  هي (63.944%) وللطلبة الأيتام هي (49.86%) وأظهرت عدم وجود علاقة ارتباطية بين مستوى الطموح والتحصيل لدى الأطفال الأيتام ووجود علاقة ارتباطية موجبة بين مستوى الطموح والتحصيل لدى الأطفال غير الأيتام في مدارس محافظات فلسطين الجنوبية، ومن أهم التوصيات  الاهتمام بطرق تنمية ورفع مستوى الطموح عند الطلبة، من خلال زيادة الوعي عند المعلمين والعاملين في المعاهد المخصصة للأيتام والمدارس التي يرتادونها  ويوصي الباحثون المسئولين في وزارة التربية والتعليم، وواضعي المناهج، بضرورة وضع مناهج تناسب عقلية الطلبة ،وتناسب المرحلة العمرية التي يمرون فيها مما يجعلهم أكثر قدرة على زيادة تحصيلهم الدراسي .والاهتمام باستراتيجيات التعليم بحيث تراعي حاجات الطلبة الأيتام وتزيد من دافعيتهم .
Literature Review: Analisis Kepuasan Pasien di Fasilitas Kesehatan Dengan Metode Service Quality
Authors: Amanda Amelia , Andarini Desheila
Published: July 2024

Kepuasan pasien merupakan salah satu indikator yang penting untuk meningkatkan kualitas layanan di fasilitas rumah sakit. Pasien yang merasa puas dengan layanan rumah sakit akan berdampak baik terhadap citra rumah sakit. Tujuan penelitian ini untuk menganalisis 5 dimensi kualitas layanan yaitu Kehandalan (Realibility), daya tanggap (Responsiveness), Jaminan (Assurance), empati (Emphaty), dan bukti fisik (Tangible) terhadap kepuasan pasien di fasilitas kesehatan. Penelitian ini menggunakan metode literature review. Hasil dari penelitian ini mayoritas seluruh artikel menyebutkan dimensi Servqual ini berdampak positif terhadap kepuasan pasien. Saran yang diberikan berdasarkan hasil literature review yang terkait dengan dimensi kualitas layanan yaitu pihak rumah sakit harus melakukan tarining atau pelatihan kepada tenaga kesehatan, melakukan pengamatan serta evaluasi secara berkala mengenai kepuasan pasien dengan menggunakan metode Service Quality di fasilitas pelayanan kesehatan.
Analysing Purchase Preference Towards Geographical Indications (GIs) Using Consumer Segmentation Approach
Authors: Baliga Vikram , Shetty Santhosha G. , Gil Mathew Thomas , Shenoy Ravindra , Rao Krithika
Published: June 2024

Consumers of local food products often face a dilemma regarding their purchase decisions due to the non-availability of information that is required to assess the quality of the product. To reduce this information asymmetry, the Geographical Indication Registry in India issues a Geographical Indication tag (GI tag) as a community right to the growers of local special products originating from a region, town or country. The GI tag symbolises uniqueness, curtails counterfeit products' spread, and reduces information asymmetry. This study has taken a select case of Udupi Mattu Gulla Brinjal, a GI horticulture produce grown by a community-based enterprise (CBE) in the Udupi District of South India. This research work aims to study and analyse consumer preference towards Udupi Mattu Gulla Brinjal (GI) using a consumer segmentation approach. The Principal Component Analysis technique has been used to identify statements with discriminatory power. Subsequently, the statements of research importance have been used to identify consumer segments using a two-step clustering approach. The study results have identified three important consumer clusters based on the analysis of consumer preference characteristics. Thereafter, marketing strategies have been proposed after analysing the profile of each segment. The study is undertaken as a response to an initiative from the Sustainable Development Goals (SDGs) Coordinating Centre, Government of India, to partner the development of agriculture in the local area of Udupi District. The objectives of the study are consistent with SDG goal 11 (sustainable communities) and SDG goal 12 (responsible consumption).
Modeling Asymmetric Effects of Exchange Rate Fluctuations on Agricultural Trade Balance: Evidence from Iran and Iraq
Authors: Hamad Mudhafar Ahmed , Falsafian Azadeh
Published: June 2024

The exchange rate plays a crucial role in foreign trade and has asymmetric effects. This study examines the asymmetric effects of exchange rate volatility on the trade balance in the agricultural sector between Iran and Iraq, using the non-linear ARDL model from 1998 to 2020. The results show that Iraq's GDP and oil price fluctuations positively affect the trade balance. In contrast, Iran's GDP and the U.S. economic sanctions against Iran have negative and significant effects on the trade balance of Iran with Iraq in the agriculture sector. The results do not confirm the existence of the J-curve effect in the trade relations between Iran and Iraq, because an increase in the bilateral exchange rate, in both the long-run and short-run, improves the trade balance of Iran with Iraq in the agriculture sector. Furthermore, the positive and negative fluctuations of the bilateral exchange rate have different effects on the trade balance. While the devaluation of the national currency does not cause a downward trend in the short run, the exchange rate policy can improve the trade balance from the beginning.
Analysis of the mutability of the legal framework for migration policy in Russia (1990-2023) in the context of the effectiveness of migration governance
Authors: Popova Svetlana Mikhailovna , Yanik Andrey Aleksandrovich , Karpova Svetlana Fyodorovna
Published: June 2024

The article analyzes the dynamics of changes in the institutional and legal framework of Russian migration policy from 1990 to 2023. Based on legal statistics, the authors investigate the frequency of amendments to key laws in the field of migration regulation in the Russian Federation. By comparing the series of events in political, legal, and institutional changes to migration governance, the authors identify external factors that influence the changes in legislation. Through comparative legal methods and an analysis of relevant literature, we discuss issues related to the differences between adaptive governance and agile management, as well as the impact of rapidly changing laws on the stability of the legal system. The analysis of the data revealed a high frequency of changes to migration laws, with an average of up to 5-6 amendments per year, and in some cases, up to 15-17 amendments per year. Acts of federal and regional authorities are also frequently amended. During the pandemic, a decision of the Moscow government was in effect for a little over a week. There is a significant excess in the number of secondary legal acts compared to the number of primary ones. The constant amendment of migration regulations reflects the state's response to diverse and sometimes unforeseen challenges in modern society, and demonstrates the adaptive nature of Russia's migration policy. This increase in adaptability raises questions about where the line is between improving the efficiency of legal regulations and their instability. Additionally, a special multidisciplinary approach is required to assess how changes in migration policies affect socio-economic development. The relevance of this study is linked to the fact that improving the efficiency of migration governance is a challenging task. Migration is both a source of economic development and potential risk to socio-political stability.
Antibacterial Properties of Wurtzite-hydrozincite Mixed-phase Phyto-synthesized ZnO Particles
Authors: Eneva Rumyana , Stoyanova Daniela , Stambolova Irina , Mitova Simona , Engibarov Stephan , Lazarkevich Irina
Published: June 2024

In this study, wurtzite-hydrozincite mixed-phase nanoparticles were prepared using a Mentha arvensis leaves extract as a stabilizing/reducing agent, followed by hydrothermal treatment at 180 °C. The resulting powder samples were characterized by X-ray diffraction (XRD) phase analysis and by Transmission Electron Microscopy (TEM). The existence of biphasic zinc oxide nanoparticles with hydrozincite and wurtzite crystallographic phases was proven. The particles sizes of biosynthesized oxide powders decreased upon the increase in the Mentha arvensis extract concentration. The antibacterial properties of the nanoparticles were investigated under dynamic contact conditions and the resazurin microplate method, using test strains with diverse structural and biochemical features. The effect of mixed-phase ZnO nanoparticles on the animal pathogens Erysipelothrix rhusiopathiae and Aeromonas caviae is studied for the first time. It was established, that the three powders exert significant antibacterial activity, which is higher against Gram-negative test microorganisms, whereupon the sample with the smallest particle sizes (G-Z3) exhibits the most effective inhibition. It could be supposed that the combination of factors: the presence of two phases, reactive oxygen species formation; small particles sizes and surface defects have beneficial effect on enhancement of their antibacterial properties.
Evaluating the in Vitro Biological Efficacy of Novel Ketoprofen Hybrids against Inflammation, Arthritis, and Oxidative Stress
Authors: Manolov Stanimir , Bojilov Dimitar , Ivanov Iliyan
Published: June 2024

In this study, we disclose the outcomes of the biological assessment of recently synthesized hybrids of ketoprofen with 2-phenylethylamines and 1,2,3,4-tetrahydroisoquinolines. These hybrids were obtained using an environmentally friendly method that minimizes the generation of waste products. The newly acquired hybrids were analysed to evaluate their antioxidant, anti-inflammatory, and anti-arthritic activities. Additionally, as potential drugs exhibiting favourable results, their experimental partition coefficient in a biphasic system of lipids and water (logP) was determined.
The Effect of Low-Dose Ionizing Radiation (Computer Tomography) on the Functional Parameters of Male Gametes
Authors: Dimitrova Tsvetomira , Hristova Elena , Sharkov Vanyo , Velichkov Andrey , Todorov Plamen
Published: June 2024

Human semen (native and processed) was treated with different doses of ionizing radiation. The influence of the irradiation on motility, DNA fragmentation and level of apoptosis of spermatozoa has been investigated. The obtained results point out that the treatment of the samples with dosages usually used in medicinal diagnostics (computer tomography) does not have any effect on the total motility of the spermatozoa, but does influence certain specific kinetic parameters – amplitude of lateral head displacement (ALH) and beat/cros frequency (BCF). We did not observe any differences in the percentage DNA fragmentation between the experimental and the control groups. Irradiation with low-dose ionizing emissions increases the proportion of gametes in early apoptosis stage and the effect is dose-dependent.
A Prototype of Big Data Platform for Seniors Care
Authors: Chikalanov Alexandre , Kirilov Leoneed , Nikolov Roumen , Lyubenova Mariyana , Petkov Yuliyan
Published: June 2024

The global elderly population is on the rise. By 2050, it is projected to reach 1.5 billion. That is why society should pay attention to this phenomenon with due attention. One effective strategy for this challenge is leveraging modern IT technologies. In line with this, we propose the prototype of a new platform designed for elderly care. Its architecture is structured into four layers: UX/UI, business logic, service program, and a diverse device layer. A significant strength of this platform is its comprehensive suite of microservices, which includes a medical manager, a personal daily schedule (PDS) manager, and a questionnaire manager. Another notable feature of the platform is its capability to work with Big Data, enhancing its utility and scope. Additionally, the prototype incorporates a variety of Internet of Things (IoT) technologies. The platform is implemented with FIWARE components.
Impact of Different Infertility Diagnoses on the Cost of Ovarian Hyperstimulation and Clinical Outcomes in IVF/ICSI Cycles
Authors: Benbassat Boriana , Ibryam Ibryam , Benbassat Niko , Slavov Sergei , Kostov Ivan
Published: June 2024

The aim of this study was to analyze the impact of different infertility diagnoses on the cost of ovarian stimulation and clinical outcomes in IVF/ICSI cycles. The study was performed in specialized gynecology clinic in Bulgaria and included 640 patients undergoing IVF/ICSI cycles during the period 2016--2020. We found that there were statistically significant differences in mean controlled ovarian hyperstimulation (COH) cost for male factor, tubal factor, and unexplained infertility. The results have shown that the cost of COH statistically differs for male factor patients without live birth. In terms of IVF/ICSI outcomes, the results demonstrate that clinical pregnancies and live births depend on infertility reason. In conclusion, the cost of COH therapy depends on infertility reasons and differs for groups with achieved clinical pregnancies and live births. There was an evidence that higher cost is connected with higher birth rate and lower miscarriages but it strongly depends on infertility reasons.
Harezmi Eğitim Modeli’nin Uygulayıcıları Olan Öğretmenlerin Görüşleri Doğrultusunda İncelenmesi
Authors: Coşkun Keskin Sevgi , Karaloğlu İbrahim , Erdoğan Hasan
Published: June 2024

Her alanda sürekli yeniliklerin ve buna bağlı olarak değişimlerin meydana geldiği dünyada, toplumun uyum içinde yaşamasını sağlamaya çalışan eğitim alanında da hiç kuşkusuz birtakım yenilikler ve bunun doğal sonucu olarak dönüşümler yaşanmaktadır.Bireylerin zaman içerisinde değişen ihtiyaçları birçok alanda olduğu gibi eğitimde de farklı uygulamaları beraberinde getirmiştir.Bu bağlamda Milli Eğitim Bakanlığı yapılandırmacı yaklaşım çerçevesinde eğitim programı hazırlamıştır.2005 yılında yürürlüğe girenbu program ileöğrencilerin etkin rol alarak yani yaparak yaşayarak öğrenmesi hedeflenmiştir. Çünkü yapılandırmacılıkta öğrenme, önceki bilgiler ve yeni bilgiler arasında etkileşimler sonucu ilişkilerin kurulması esasına dayanır. Ayrıca 21. yüzyılda yaşanan teknolojik değişim ve gelişimtoplumun en önemli unsurlarından biri haline gelmiştir. Bu bağlamda öğrencinin öğrenme sürecinde aktif olduğu hem de teknolojinin eğitim-öğretim ortamında etkin bir şekilde uygulandığı modellerden biri de Harezmi Eğitim Modeli’dir. Yapılan bu çalışmada, uygulanan bu modelin niteliğinin ortaya konulması amaçlanmıştır. Harezmi Eğitim Modeli’nin uygulayıcıları olan öğretmenlerin görüşleri doğrultusunda incelenmesinin amaçlandığı bu çalışma nitel araştırma yöntemlerinden fenomenoloji (olgu bilim) deseni ile yürütülmüştür. Araştırmanın katılımcı grubunu İstanbul ili Ümraniye ilçesinde bulunan farklı okullarda görev yapan ve Harezmi Eğitim Modeli’ni uygulayan farklı branşlardan yirmi beş öğretmen oluşturmaktadır. Araştırmaya katılan öğretmenlerin Harezmi Eğitim Modeli’ne ilişkin görüş ve düşüncelerini belirlemek amacıyla yarı yapılandırılmış görüşme formu hazırlanmıştır. Araştırma sonucunda Harezmi Eğitim Modeli’nin yapılandırmacı öğrenme kuramıyla benzerlik gösterdiği, hem öğretmenlerin hem de öğrencilerin birbirinden farklı birçok alanda kişisel gelişimlerine katkı sağladığı, aynı zamanda öğretmenlerin mesleki olarak kendilerini geliştirmelerine olanak sunduğu söylenebilir.
Laboratory Maintenance of Methicillin‐Resistant Staphylococcus aureus (MRSA)
Authors: Vitko Nicholas P. , Richardson Anthony R.
Published: February 2013

Staphylococcus aureus is an important bacterial pathogen in the hospital and community settings, especially Staphylococcus aureus clones that exhibit methicillin‐resistance (MRSA). Many strains of S. aureus are utilized in the laboratory, underscoring the genetic differences inherent in clinical isolates. S. aureus grows quickly at 37°C with aeration in rich media (e.g., BHI) and exhibits a preference for glycolytic carbon sources. Furthermore, S. aureus has a gold pigmentation, exhibits β‐hemolysis, and is catalase and coagulase positive. The four basic laboratory protocols presented in this unit describe how to culture S. aureus on liquid and solid media, how to identify S. aureus strains as methicillin resistant, and how to generate a freezer stock of S. aureus for long‐term storage. Curr. Protoc. Microbiol. 28:9C.2.1‐9C.2.14. © 2013 by John Wiley & Sons, Inc.
Gene Transfer in Skeletal and Cardiac Muscle Using Recombinant Adeno‐Associated Virus
Authors: Gruntman Alisha M. , Bish Lawrence T. , Mueller Christian , Sweeney H. Lee , Flotte Terence R. , Gao Guangping
Published: February 2013

Adeno‐associated virus (AAV) is a DNA virus with a small (∼4.7 kb) single‐stranded genome. It is a naturally replication‐defective parvovirus of the dependovirus group. Recombinant AAV (rAAV), for use as a gene transfer vector, is created by replacing the viral rep and cap genes with the transgene of interest along with promoter and polyadenylation sequences. Only the viral inverted terminal repeats (ITRs) are required in cis for replication and packaging during production. The ITRs are also necessary and sufficient for vector genome processing and persistence during transduction. The tissue tropism of the rAAV vector is determined by the AAV capsid. In this unit we will discuss several methods to deliver rAAV in order to transduce cardiac and/or skeletal muscle, including intravenous delivery, intramuscular delivery, isolated limb infusion, intrapericardial injection in neonatal mice, and left ventricular wall injection in adult rats. Curr. Protoc. Microbiol. 28:14D.3.1‐14D.3.19. © 2013 by John Wiley & Sons, Inc.
Human Immunodeficiency Viruses: Propagation, Quantification, and Storage
Authors: Peters Paul J. , Richards Kathryn , Clapham Paul
Published: February 2013

Described in this unit are basic protocols frequently used in the research of human immunodeficiency viruses (HIVs). Provided are methods for propagating and quantifying HIV, as well as recommendations for long‐term storage. Background information about these methods is also provided and includes their advantages, disadvantages, and troubleshooting.Curr. Protoc. Microbiol. 28:15J.1.1‐15J.1.24. © 2013 by John Wiley & Sons, Inc.
A generalizedG‐function for the Quantum Rabi Model
Authors: Braak Daniel
Published: February 2013

The analytical solution of the quantum Rabi model is based on a transcendental function, the zeros of which determine the eigenenergies.is generalized here to a function, which allows a much better numerical control of the high‐energy part of the spectrum by an appropriate choice of the complex parameterz. Additionally, it is shown that all zeros ofcorrespond to eigenvalues of the Hamiltonian as well as the zeros offor imaginaryz.
Oxytocin and Vasopressin in Children and Adolescents With Autism Spectrum Disorders: Sex Differences and Associations With Symptoms
Authors: Miller Meghan , Bales Karen L. , Taylor Sandra L. , Yoon Jong , Hostetler Caroline M. , Carter Cameron S. , Solomon Marjorie
Published: February 2013

There has been intensified interest in the neuropeptides oxytocin (OT) and arginine vasopressin (AVP) in autism spectrum disorders (ASD) given their role in affiliative and social behavior in animals, positive results of treatment studies using OT, and findings that genetic polymorphisms in the AVP–OT pathway are present in individuals with ASD. Nearly all such studies in humans have focused only on males. With this preliminary study, we provide basic and novel information on the involvement of OT and AVP in autism, with an investigation of blood plasma levels of these neuropeptides in 75 preadolescent and adolescent girls and boys ages 8–18: 40 with high‐functioning ASD (19 girls, 21 boys) and 35 typically developing children (16 girls, 19 boys). We related neuropeptide levels to social, language, repetitive behavior, and internalizing symptom measures in these individuals. There were significant gender effects: Girls showed higher levels of OT, while boys had significantly higher levels of AVP. There were no significant effects of diagnosis on OT or AVP. Higher OT values were associated with greater anxiety in all girls, and with better pragmatic language in all boys and girls. AVP levels were positively associated with restricted and repetitive behaviors in girls with ASD but negatively (nonsignificantly) associated with these behaviors in boys with ASD. Our results challenge the prevailing view that plasma OT levels are lower in individuals with ASD, and suggest that there are distinct and sexually dimorphic mechanisms of action for OT and AVP underlying anxiety and repetitive behaviors. Autism Res 2013, 6: 91–102. © 2013 International Society for Autism Research, Wiley Periodicals, Inc.
Ultradeep sequencing detects GNAQ and GNA11 mutations in cell‐free DNA from plasma of patients with uveal melanoma
Authors: Metz Claudia H. D. , Scheulen Max , Bornfeld Norbert , Lohmann Dietmar , Zeschnigk Michael
Published: February 2013

Elevated levels of cell‐free DNA (cfDNA) are frequently observed in tumor patients. Activating mutations in exon 4 (R183) and exon 5 (Q209) of GNAQ and GNA11 are almost exclusively found in uveal melanoma, thus providing a highly specific marker for the presence of circulating tumor DNA (ctDNA). To establish a reliable, noninvasive assay that might allow early detection and monitoring of metastatic disease, we determined the proportion of GNAQ or GNA11 mutant reads in cfDNA of uveal melanoma patients by ultradeep sequencing. Cell‐free DNA from 28 uveal melanoma patients with metastases or extraocular growth was isolated and quantified by real‐time polymerase chain reaction (PCR) (7–1550 ng DNA/mL plasma). GNAQ and GNA11 regions of interest were amplified in 22 of 28 patients and ultradeep sequencing of amplicons was performed to detect even low proportions of mutant reads. We detected Q209 mutations (2–38% mutant reads) in either GNAQ or GNA11 in the plasma of 9 of 22 metastasized patients. No correlation between the proportion of mutant reads and the concentration of cfDNA could be detected. Among the nine ctDNA‐positive patients, four had metastases in bone, whereas no metastases were detected in the 13 ctDNA‐negative patients at this location (P = 0.025). Furthermore, ctDNA‐positive patients tended to be younger at initial diagnosis and show larger metastases. The results show that ultradeep amplicon sequencing can be used to detect tumor DNA in plasma of metastasized uveal melanoma patients. It remains to be shown if this approach can be used for early detection of disseminated tumor disease.
Intravascular ultrasound analysis of small vessel lesions treated with the sparrow coronary stent system: Results of the CARE II trial
Authors: Kume Teruyoshi , Waseda Katsuhisa , Koo Bon‐Kwon , Yock Paul G. , Botelho Roberto , Verheye Stefan , Whitbourn Robert , Meredith Ian , Worthley Stephen , Hai Koh Tian , Honda Yasuhiro , Abizaid Alexandre , Fitzgerald Peter J.
Published: February 2013

Objectives

The aim of this study was to evaluate the Sparrow sirolimus‐eluting stent (Sparrow‐SES) against the Sparrow bare‐metal stent (Sparrow‐BMS) and conventional balloon‐expandable bare‐metal stent (BMS: Driver/Micro‐Driver® stent, Medtronic Vascular, Santa Rosa, CA).

Background

The Sparrow® stent (Biosensors International, Singapore) consists of a guide wire‐based, self‐expandable, ultra‐thin nitinol stent. The performance of this device with sirolimus in a fully biodegradable polymer has not been determined.

Methods

A total of 74 patients were included in this intravascular ultrasound (IVUS) sub‐study of the CARE II trial, which was a prospective, randomized, multicenter trial in the treatment of single de novo native coronary artery lesions in vessels ranging from 2.0 mm to 2.75 mm in diameter (Sparrow‐SES: n = 31, Sparrow‐BMS: n = 22, BMS: n = 21).

Results

Stent volume index (VI) was significantly increased 8‐month later in Sparrow‐SES and Sparrow‐BMS, but not in BMS (4.0±1.0 to 4.6±1.0 mm3/mm, p<0.0001, 4.0±0.6 to 4.4±0.8 mm3/mm, p<0.05, and 5.2±1.0 to 5.1±0.9 mm3/mm, p=0.421, respectively). % neointimal obstruction in Sparrow‐SES was significantly smaller than those in Sparrow‐BMS and BMS at follow‐up (17.6±9.4 vs. 36.2±13.8 and 39.9±11.1%, p<0.001). Sparrow‐SES showed a mean 15% stent expansion and good suppression of neointimal proliferation, resulting in a significantly lower percentage of change in lumen VI during follow‐up period (Sparrow‐SES: −6.2±16.2%, Sparrow‐BMS: −30.4±11.6%, BMS: −40.4±10.0%, p<0.001).

Conclusions

The self‐expanding Sparrow‐SES demonstrated chronic stent expansion, good suppression of neointimal proliferation and resulted in a more preserved lumen in stented small vessels compared with the Sparrow‐BMS and conventional balloon expandable BMS. © 2013 Wiley Periodicals, Inc.
Variability in quantitative and qualitative analysis of intravascular ultrasound and frequency domain optical coherence tomography
Authors: Abnousi Freddy , Waseda Katsuhisa , Kume Teruyoshi , Otake Hiromasa , Kawarada Osami , Yong Celina M. , Fitzgerald Peter J. , Honda Yasuhiro , Yeung Alan C. , Fearon William F.
Published: February 2013

Background

Frequency‐domain optical coherence tomography (FD‐OCT) is an intravascular imaging technique now available in the United States. However, the importance of level of training required for analysis using intravascular ultrasound (IVUS) and FD‐OCT is unclear. The aim of this study was to evaluate inter‐ and intra‐observer variability between expert and beginner analysts interpreting IVUS and FD‐OCT images.

Methods and Results

Two independent expert analysts and two independent beginner analysts evaluated a total of 226 ± 2 stent cross‐sections with IVUS and 232 ± 2 stent cross‐sections with FD‐OCT in 14 patients after stenting. Inter‐ and intra‐observer variability for determining stent volume index (VI), as well as identifying incomplete stent apposition and dissection were assessed. The inter‐ and intra‐observer variability of stent VI was minimal for both beginner and expert analysts regardless of imaging technology (random variability: 0.38 vs. 0.05 mm3/mm for IVUS, 0.26 vs. 0.08 mm3/mm for FD‐OCT). Although qualitative IVUS analysis at the patient level revealed no significant difference between beginners and experts, this was not the case for FD‐OCT. The number of overall qualitative findings noted by beginner and expert analysts were more variable (overestimated or underestimated) with FD‐OCT.

Conclusion

Despite varying levels of training, the increased resolution of FD‐OCT compared to IVUS provides better detection and less variability in quantitative image analysis. On the contrary, this increased resolution not only increases the rate but also the variability of detection of qualitative image analysis, especially for beginner analysts. © 2013 Wiley Periodicals, Inc.