bluuebunny/crossref_metadata_2025 huggingface dataset:
Feline Obesity Causes Hematological And Biochemical Changes And Oxidative Stress
Authors: Martins Tainara Oliveira , Ramos Rebecca Cápera , Possidonio Geovana , Bosculo Maria Rachel Melo , Oliveira Paula Lima , Costa Leticia Ramos , Zamboni Vinicius Aquiles Gomes , Marques Marcel Gambin , Almeida Breno Fernando Martins
Published: March 2022

Obesity, an extremely important factor in feline clinical practice, is estimated to affect up to one third of the feline population. Moreover, it can trigger chronic inflammation, which could predispose to oxidative stress by increasing reactive oxygen species, thereby generating potentially irreversible cellular damage. This study analyzed hematological, biochemical and oxidative stress profiles at various degrees of feline obesity. Forty-five cats were selected and divided into three groups: control (n=17), overweight (n=13) and obese (n=15), after clinical and laboratory evaluation and body condition score. Biochemical and oxidative stress analyses were performed using a photocolorimeter and hematological analyses were performed in a veterinary cell counter. The hematological profile of obese cats showed increased mean corpuscular volume (MCV) and red cell distribution width (RDW), while their biochemical profile revealed increased HDL cholesterol and triglycerides and decreased activity of gamma-glutamyl transferase (GGT). As for oxidative stress, obese cats showed higher total antioxidant capacity (TAC), by the inhibition of 2,2’-Azino-Bis-3-Ethylbenzthiazoline-6-Sulfonic Acid (ABTS), inhibition of ABTS associated with horseradish peroxidase (ABTS+HRP), cupric ion reducing antioxidant capacity (CUPRAC) and ferric reducing antioxidant power (FRAP) methods, while overweight cats had a higher TAC-ABTS+HRP and TAC-FRAP. We conclude that the conditions of natural obesity and overweight in the feline species alter its hematological, biochemical and oxidative stress parameters.
Finding a Needle in a Haystack: larval Stages of Didymozoidae (Trematoda: Digenea) Parasitizing Marine Zooplankton
Authors: Lozano-Cobo Horacio , Oceguera-Figueroa Alejandro , Silva-Segundo Claudia A. , Robinson Carlos J. , Gómez-Gutiérrez Jaime
Published: March 2022

Larval didymozoids (Trematoda, Digenea) were discovered parasitizing the hemocoel of the heteropod Firoloida desmarestia (redia mean intensity = 13) and the chaetognaths Flaccisagitta enflata and Flaccisagitta hexaptera (metacercaria mean intensity = 1) during a 2014–2016 systematic study of parasites of zooplankton collected in the central and southern regions of the Gulf of California, Mexico. Didymozoid infection route during the early life cycle was inferred combining morphological and molecular evidence (light and scanning electron microscopy and mitochondrial cytochrome c oxidase subunit I gene, cox1, respectively). Didymozoid rediae parasitizing F. desmarestia were observed alive releasing hundredths of cystophorous cercariae at a mean rate of one cercariae every 12 s. Cercariae developed into young metacercariae in 1 d at 22°C. Molecular analysis of cox1 showed that rediae found in F. desmarestia belong to two distinct didymozoid species (Didymozoidae sp. 1 and sp. 2). Metacercariae parasitizing chaetognaths were morphologically identified as Didymozoidae type Monilicaecum and cox1 sequences showed that metacercariae of chaetognaths matched with these two Didymozoidae sp.1, and sp. 2 species found parasitizing F. desmarestia, plus a third distinct Didymozoidae sp. 3. These are the first DNA sequences of cox1 gene from didymozoid larvae for any zooplankton taxonomic group in the world. We concluded that F. desmarestia is the first intermediate host of rediae and second intermediate host cercariae and chaetognaths are the third intermediate hosts of didymozoid metacercariae demonstrating a potential overlap distribution of these two carnivorous zooplankton taxonomic groups. The didymozoid specimens were not identified to species level because any of the cox1 sequences generated here matched with the sequences of adult didymozoids currently available in GenBank and Bold System databases. This study provides valuable information for the morphological and molecular understanding of the Didymozoidae larvae that has been previously based on the recognition of the 12 known morphotypes.
The Efficacy and Safety of Second-Line Chemotherapy for Patients with Advanced Non-Small Cell Lung Cancer Complicated by Interstitial Lung Disease
Authors: Otsuka Kenji , Nokihara Hiroshi , Mitsuhashi Atsushi , Ozaki Ryohiko , Yabuki Yohei , Yoneda Hiroto , Ogino Hirokazu , Nishioka Yasuhiko
Published: March 2022

Background: Treatment of non-small cell lung cancer (NSCLC) patients with interstitial lung disease (ILD) is limited because of the risk of its acute exacerbation (AE). Furthermore, the efficacy and safety of second-line chemotherapy for these patients is unclear.Patients and Methods: To investigate the efficacy and safety of second-line chemotherapy for NSCLC patients with ILD, we retrospectively reviewed the patients who were treated at our institute between April 2010 and December 2018.Results: Thirty-five patients received two or more regimens. Thirty-four patients were male and the median age at the initiation of second-line chemotherapy was 70 years. Almost all patients had a smoking history. Fourteen patients had adenocarcinoma and 15 had squamous cell carcinoma histology. Stages Ⅲ and Ⅳ were observed in 20 and 11 patients, respectively. With respect to the type of ILD, 12 patients had usual interstitial pneumonia (UIP). The overall response rate and disease control rate were 11.4% and 68.6%, respectively. The median progression-free survival and median overall survival were 4.1 months and 6.4 months, respectively. The AE of ILD was observed in eight patients, five of whom died. UIP and low % vital capacity were detected as significant risk factors for the AE of ILD.Conclusion: Second-line chemotherapy among patients with NSCLC complicated by ILD showed a certain effectiveness, but some patients experienced the AE of ILD, which may lead to death. The risk of the AE of ILD must be considered especially for patients with UIP and low %VC.
Tanshinone IIA Promotes Apoptosis by Down-Regulating BCL2 and Up-Regulating TP53 in Triple-Negative Breast Cancer
Authors: Liu Jinfeng , Zhang Chang , Liu Shuang , Hao Jian , Wu Xiong-Zhi , Wang Xiao-Kang
Published: March 2022

Background/Objective: Tanshinone IIA, which is mainly used for the treatment of cardiovascular diseases, has been shown to inhibit the progression of a variety of cancers in recent years. In this study, we showed that tanshinone IIA could inhibit the proliferation of triple-negative breast cancer cells and promote their apoptosis. However, the specific mechanisms were not clear. Our research aims to clarify its mechanism. Method: At the first, the effects of tanshinone IIA on cell viability of triple-negative breast cancer cell lines were analyzed. Then a mouse transplanted tumor model was used to study the anti-cancer effect in vivo. The related targets and mechanisms of tanshinone IIA were predicted through network-based systems biology and molecular docking analysis. At last, molecular docking and the molecular biological techniques were used to evaluate the predicted target. Results: Tanshinone IIA could inhibit the cell proliferation after incubation for 24 h. At a concentration of 50 µM, Tanshinone IIA could half-inhibit the proliferation of 4T1 cells. Consistent with the results of the cell viability assays, Tan IIA induced the cancer cell apoptosis and resulted in a significant reduction in tumor volume. Then we analyzed the possible mechanisms with network-based systems biology, and predicted TP53, NF-κB, AKT, MYC and BCL-2 were the hub targets of Tan IIA for triple-negative breast cancer. P53 signaling pathway, PI3K/Akt pathway, the MAPK signaling pathway and the mTOR signaling pathways were the possible involved mechanisms. Using molecular docking analysis, we found Tan IIA has a high affinity for p53, Bcl-2 and NF-κB1, the binding energy were − 6.92, -6.07 and − 6.28 kcal/mol, respectively. Through western blotting assays, we further found the p53 protein expression was increased while Bcl-2 protein was decreased after Tan IIA treatment. These results verified that Tan IIA promotes apoptosis by down-regulating BCL2 and up-regulating TP53 in triple-negative breast cancer.Conclusion: Our findings revealed the mechanism of Tan IIA in promoting apoptosis and inhibiting proliferation in triple-negative breast cancer cells, which provides a theoretical and experimental basis for further research into the anticancer effects of Tan IIA.
High efficiency sorting and outgrowth for single-cell cloning of mammalian cell lines
Authors: Munoz Adonary , Morachis Jose
Published: March 2022

To simplify single-cell cloning with the ability of sorting specific target populations of interest with a higher cell outgrowth, several cell lines were sorted onto 96-well plates containing cloning media formulations to enhance single cell survival. Cell lines that were tested included suspension cells (CHO ES, Expi293F, and Jurkat) and adherent cells (MCF7, A549, and HEK293). In parallel with the single-cell sorting experiments, limiting dilution at 0.5 cells/well was used as a control for viability relative to sorting and to demonstrate the increased efficiency of using the WOLF and N1 single-cell dispenser for cell line development. The combined use of the cell sorter and optimized cloning medium resulted in greater than 50% cell outgrowth. The WOLF with the N1 achieves cell line development goals by sorting specific cells with gentle sorting resulting in high probabilities of monoclonal outgrowth.
Bioactivity of Bryophyllum pinnatum and Rauvolfia vomitoria on Neonatal Group B Streptococcus
Authors: Ojo Stephen Kayode .S. , Udewena Linda Uchenna , Adetunji Charles O.
Published: March 2022

Background
Group B Streptococcus (GBS) is a harmless commensal bacterium in healthy adults but it causes sepsis in neonates resulting in a high rate of mortality. This study was carried out to investigate the antibacterial activity of Bryophyllum pinnatum and Rauvolfia vomitoria bioactive fractions on thirty-five multidrug resistant Group B Streptococcus (GBS) strains implicated on neonatal sepsis as well as to identify the antibiotic resistant genes present. The phytochemical analyses were carried out using column chromatography. Antibacterial activity, Minimum Inhibitory Concentration (MIC) and Minimum Bacteria Concentration (MBC) of the different plant biofractions was determined using disc diffusion technique. The presence of erythromycin (ermB) and tetracycline (tetO) resistant genes was identified using duplex PCR techniques. Graphing was done using Graph pad prism (version 5.0a).
Result
The results obtained from this study show that the selected plants have dose dependent activity against GBS. Ethanol biofraction of R. vomitoria had the highest activity with an MIC value ranges between 12.5 mg/ml and 50 mg/ml and MBC ranges from 25 mg/ml and 50 mg/ml followed by methanol biofraction of B. pinnatum with an MIC value ranging between 50mg/ml and 100mg/ml on 32 out of the 35 strains investigated, leaving the other three having MIC values of 25 mg/ml then MBC values ranging between 50 mg/ml and 100mg/ml while N-hexane and aqueous biofractions had the least activity. Also, the presence of ermB and tetO resistant genes were present in all the ten representative GBS strains tested.
Conclusion
The high rate of activity shown by the methanol and ethanol extracts of both plants suggests that the plants can serve as a potential alternative for the treatment of neonatal sepsis. However, a further study on their in vivo activity is important in order to evaluate the efficiency, safety and potential adverse effects and drug herb interactions of the plants.
GRAVITATIONAL CASIMIR EFFECT IN INSPIRALLING NEUTRON STAR BINARY
Authors:   School of Physical Science and Technology, Guangxi Normal University, Guilin, 541004, PR China., Wang Jing
Published: March 2022

Currently, the discussions and investigations for the vacuum energy are drawing great both theoretical and experimental attention. The vacuum states of variety of fields, subject to special boundary conditions, may contribute to non-trivial macroscopic vacuum energy, i.e., the Casimir effect, which become an interdisciplinary subject and plays an important role in a variety of fields of physics. We adopt Schwingers source theory and study the quantization of gravitation contributions to the Casimir effect, i.e., the gravitational Casimir effect, in inspiraling neutron star binaries with wide separation of 109 m. By considering gravitoelectromagnetism (GEM) arising from the spiral-in orbital motion and evaluating the gravitoelectromagnetic contributions to the vacuum energy of gravitons radiated during the orbital decay, we demonstrate that, when the radial separation of the system decay a distance L, the GEM results in a small Casimir correction to the gravitational vacuum energy, which contributes to an attractive gravitational Casimir force to the binary, in addition to the gravitational force. We also discuss the possible detections for such gravitational Casimir effect from both the future space-based gravitational wave observatories and cosmological observations.
Managerial ability, corporate governance, and IFRS adoption as determinants of earnings management: Evidence from Indonesia
Authors: Hakim Luqman , Rahayu Dewi , Endri Endri
Published: March 2022

Earnings management practices revealed in companies are primarily determined by the role of management in providing the best performance reports for shareholders. The purpose of this study was to analyze the effect of managerial ability, independent commissioners, audit committees, quality of external auditors, and the application of International Financial Reporting Standards (IFRS) on earnings management practices. The research data were retrieved from manufacturing sector companies listed on the Indonesia Stock Exchange from 2014 to 2018. These data are analyzed using a panel data regression model. The empirical findings of the study prove that managerial ability, quality of external auditors, and the application of IFRS have a positive effect on earnings management.In contrast, independent commissioners have a negative effect. The audit committee does not affect earnings management. This study also reveals that the variables of corporate governance mechanisms, which consist of independent commissioners, audit committees, and the quality of external auditors, have different effects on earnings management practices. This indicates that corporate governance principles have not been appropriately implemented in a company. The managerial ability has a dominant role in carrying out old management practices with various manipulations of financial statements.
Pengaruh Keadilan Distributif, Keadilan Prosedural, Keadilan Interaksional terhadap Kepuasan Konsumen, WOM Positif, WOM Negatif dan Niat Membeli Ulang Konsumen
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Albertus Christian , Neysa Gavrila ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Istijanto Istijanto ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Budiman Arief ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Kegagalan dalam layanan merupakan hal yang tidak dapat dihindari. Komplain terkait dengan kegagalan yang terjadi pada kolom ulasan di toko online merupakan bukti bahwa kegagalan layanan selalu terjadi. Berkaitan dengan masalah ini, para penjual online terkadang tidak mengetahui apakah penanganan pada kegagalan tersebut dapat memengaruhi bisnis mereka. Penelitian sebelumnya, Lin, Wang & Chang (2011) menguji kegagalan layanan dan pengaruhnya terhadap penyebaran WOM negatif. Pada penelitian ini, peneliti melihat adanya kemungkinan bahwa kegagalan layanan yang ditangani dengan baik tidak hanya akan memengaruhi penyebaran WOM negatif, melainkan penyebaran WOM positif dan niat membeli ulang konsumen. Oleh karena itu penelitian ini dilakukan untuk mengetahui apakah kegagalan layanan yang direspon dengan berbagai macam jenis pemulihan dapat memengaruhi kepuasan konsumen, penyebaran WOM positif, WOM negatif, dan niat membeli ulang. Menggunakan teknik penelitian eksperimen dengan model desain faktorial 2x2x2, konsumen pada penelitian ini dikondisikan dengan kombinasi dari variabel independen yang ada yaitu keadilan distributif yang berkaitan dengan kompensasi, keadilan prosedural yang berkaitan dengan prosedur pembelian, dan keadilan interaksional yang berkaitan dengan komunikasi pelayanan. Pengumpulan data disusun berdasarkan kombinasi rendah dan tinggi antara variabel tersebut dan menghasilkan delapan skenario. Hasil dari uji manipulasi menunjukkan angka yang konsisten sehingga peneliti dapat melanjutkan ke tahap main test. Selanjutnya, peneliti mengumpulkan data menggunakan kuesioner yang disebarkan kepada 240 responden. Kemudian, hasil yang terkumpul diolah menggunakan SPSS. Penelitian ini menemukan bahwa keadilan distributif, keadilan prosedural, dan keadilan interaksional memiliki efek langsung terhadap kepuasan konsumen, WOM positif, WOM negatif dan niat membeli ulang. Hasil penelitian ini juga dapat berguna bagi penjual online saat melakukan pemulihan layanan dimana hanya dengan melakukan keadilan interaksional, penjual online dapat meningkatkan kepuasan konsumen, WOM positif, niat membeli ulang dan menurunkan WOM negatif.
Pengaruh Green Perceived Value dan Green Perceived Risk terhadap Green Trust, Green Purchase Intention, dan Green Purchase Behavior pada Produk Green Cosmetics di Indonesia, Studi Kasus: Sensatia Botanicals
Authors:   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Az Zahra Rusin Falaha Rahmatia , Pratama Kevin ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ardianto Eka ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Ali Alavi ,   Sekolah Bisnis dan Ekonomi, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: March 2022

Cakupan penelitian mengenai intensi dan perilaku pembelian produk telah banyak dibahas dalam studi penelitian manajemen terutama dalam bidang ilmu pemasaran di Indonesia. Namun, penelitian yang membahas green purchase behavior dalam konteks green cosmetics sendiri masih sangat terbatas. Penelitian ini akan membahas mengenai pengaruh green perceived value dan green perceived risk terhadap green trust, green purchase intention, dan green purchase behavior pada produk green cosmetics di Indonesia, khususnya daerah Jabodetabek. Dalam penelitian ini, peneliti meneliti salah satu brand green cosmetics lokal yakni Sensatia Botanicals. Data dikumpulkan secara purposive sebanyak 159 responden yang sudah pernah melakukan pembelian terhadap green cosmetics Sensatia Botanicals. Pengambilan data dilakukan melalui penyebaran kuesioner online selama bulan Juli 2019. Data diolah menggunakan aplikasi SPSS 23 dan menggunakan Structural Equation Modeling dengan AMOS 23. Hasil menunjukkan bahwa pembentukan green trust dipengaruhi oleh green perceived value. Dengan kata lain, terdapat kesesuaian value lingkungan yang dimiliki konsumen dan produsen sehingga mempengaruhi green trust konsumen. Di sisi lain, tidak terdapat hubungan antara green perceived risk dan green trust dalam pembelian produk green cosmetics. Selain itu, penelitian ini membuktikan bahwa green trust mempengaruhi green purchase intention konsumen Sensatia. Temuan lainnya adalah konsumen Sensatia Botanicals telah menunjukkan perilaku pembelian terhadap produk ramah lingkungan secara rutin.
Rol de género y percepción de bienestar y felicidad en universitarios del noroeste de México
Authors: Abril Valdez Elba , Cubillas Rodríguez Maria José , Domínguez Ibáñez Sandra Elvia , Román Pérez Rosario , Córdova Moreno María Alejandra
Published: March 2022

En el contexto actual, ser joven y universitario plantea nuevos retos y transformaciones que dan lugar a situaciones de estrés que se pueden reflejar en la percepción de felicidad y bienestar. El género influye también en esa percepción, a partir de lo socialmente esperado para cada sexo. Las diferencias en el rol de género, expresado a partir de los atributos asignados socialmente a cada sexo —ya sea masculino, femenino, andrógino o indiferenciado— pueden influir en la forma en que se perciben y se enfrentan los problemas en lo cotidiano, dando lugar a una percepción diferente de la felicidad o el bienestar. Por lo anterior, se plantea como objetivo lo siguiente: analizar, a partir del Índice de Felicidad de Pemberton, la relación entre la percepción de bienestar y el rol de género en estudiantes universitarios de Sonora. 
Los resultados muestran que la coexistencia de atributos femeninos y masculinos positivos, independientemente del sexo, dan una perspectiva favorable de la interacción con su entorno y de la forma en que resuelven sus problemas las y los jóvenes de la muestra estudiada. La construcción social del género explica la persistencia de roles tradicionales, pero también la emergencia de formas más equilibradas de incorporación de atributos considerados femeninos y masculinos, para una mejor percepción de felicidad y bienestar.
Abordagem Terapêutica na Cardiomiopatia Hipertrófica, uma Revisão Integrativa
Authors: Areco Barreto Eduardo , Almeida Cassaniga Rafaela , Picone Borges De Aragão Ivana
Published: March 2022

A cardiomiopatia hipertrófica (CMH) é uma doença genética dominante que afeta um em 500 indivíduos. O diagnóstico é confirmado por exames de imagem através da identificação de hipertrofia parede septal do ventrículo esquerdo ≥ 15 mm. Possui uma fisiopatologia complexa que envolve a disfunção diastólica, infartos do miocárdio por aumento de demanda de oxigênio, obstrução de via de saída ventricular esquerda (VSVE) e movimento mitral sistólico anterior. O objetivo desse estudo foi analisar as principais abordagens terapêuticas disponíveis atualmente, a fim de contribuir na escolha da abordagem em pacientes com CMH. Esta revisão bibliográfica integrativa utilizou o PubMed e o Scielo como plataformas eletrônicas de pesquisa, elegendo artigos publicados entre os anos de 2010 e 2020. Foram selecionados 17 artigos, de um total de 353 artigos, incialmente, identificados. Os descritores utilizados foram “hypertrophic cardiomyopathy”, “therapeutic” e “approach”. O tratamento da CMH se resume em dois pilares: medicamentoso, como primeira linha em pacientes com sintomas de insuficiência cardíaca em virtude do gradiente de pressão intraventricular devido á obstrução do trato de saída do ventrículo esquerdo, como betabloqueadores, disopiramida e bloqueadores do canal de cálcio; cirúrgico ou invasivo percutâneo, nos portadores de gradiente pressórico de VSVE > 50 mmHg. Atualmente, existem dez técnicas de correção da CMH, sendo as três mais usadas, a ablação alcoólica septal (AAS), a ablação septal por cateter de radiofrequência (ASCR) e a miectomia septal e outras sete formadas por técnicas modernas menos invasivas e possíveis alvos moleculares. Incialmente, o tratamento deve ser orientado pelo grau de obstrução do TSVE e pelos sintomas do paciente, buscando a melhor opção para cada perfil de paciente.
Análise epidemiológica de infarto agudo do miocárdio e outras doenças isquêmicas do coração no Brasil nos últimos 10 anos
Authors: Lopes Dias Juliana , De Rafael , Freitas Felipe , Picone Borges de Aragão Ivana
Published: March 2022

As doenças cardiovasculares constituem a primeira causa de morte no mundo, sendo a aterosclerose a base das doenças isquêmicas do coração, incluindo disfunção endotelial e obstrução arterial, por placas de ateroma. Clinicamente, podem se manisfestar como angina estável, angina instável, infarto agudo do miocárdio, miocardiopatia isquêmica e aneurisma aórtico. O objetivo do presente estudo foi analisar o panorama epidemiológico da doença aterosclerótica e seus desfechos isquêmicos no Brasil, utilizando dados como número de internações, faixa etária, gênero e  taxa de mortalidade, coletados a partir do DATASUS, a fim de avaliar a ascensão dessas doenças no país e concluir se nos encaminhamos para um melhor controle delas. Foi realizado um estudo descritivo e retrospectivo de coleta informações em banco de dados de domínio público do Departamento de Informática do Sistema Único de Saúde (DATASUS) e do Sistema de Informações Hospitalares do SUS (SIH/SIS) do Ministério da Saúde. Foram selecionados os diagnósticos de infarto agudo do miocárdio e outras doenças isquêmicas do coração para avaliação do número de internações, faixa etária, gênero e taxa de mortalidade, nos últimos 10 anos no Brasil, pelos diagnósticos: infarto agudo do miocárdio (IAM) e outras doenças isquemicas do coração (ODIC). Foram identificadas 1047309 internações por IAM e 1520591 ODIC no Brasil, nos últimos 10 anos, sendo o maior acometimento no sexo masculino e na faixa etária de 50 a 79 anos. O anos de maior registro foram de 2018 a 2020 e a taxa de mortalidade foi de 11,13 para IAM e 2,62 para ODIC. Sendo assim, torna-se necessário melhorar o rastreamento para doenças cardiovasculares e conscientizar a população a respeito de seus sintomas e fatores de risco.

 

Palavras chave:  infarto miocárdio; aterosclerose; isquemia miocárdica; epidemiologia
Métodos de barreira contra aerossol no manuseio da via aérea durante a pandemia da COVID-19: uma revisão de literatura
Authors: Bernardo Gabriel , Zon Filippi Ana Claudia
Published: March 2022

A disseminação e contágio pelo coronavírus ocorre por meio de gotículas e aerossóis, sobretudo em técnicas invasivas de obtenção de via aérea como a Intubação Orotraqueal (IOT). O presente estudo teve por finalidade comparar e avaliar a aplicabilidade dos métodos de proteção por barreira durante a realização da IOT e a tentativa de minimizar a dispersão de aerossóis nos ambientes de Terapia Intensiva. Foi realizada uma revisão de literatura. Dispositivos como “Aerosol Box”, “Simple Drape” e “Drape Tent” foram métodos formais de proteção do ambiente criados. No Brasil, atualmente, não há norma técnica que viabiliza o uso de métodos de barreira. Portanto, foram produzidas simulações que testaram a maior parte dos dispositivos, analisando macropartículas e micropartículas, posições do operador, modo de dispersão das gotículas e confiabilidade dos métodos. Concluiu-se que os métodos de barreira conferiram mínima proteção do ambiente e do laringoscopista, não justificando, portanto, seu uso regular nos protocolos.
Taxonomia de coisas para o dataismo
Authors: Schiel Ulrich
Published: March 2022

Existe uma tendência evidente de computadorizar cada vez mais atividades do dia-a-dia. Ferramentas de IA, de tomada de decisão e aprendizado de máquina são algumas destas tecnologias. Neste artigo analisamos como a modelagem de aplicações de bancos de dados deve evoluir para atender a estes requisitos. Coisas estruturais e ocorrêncais adequadas são consideradas e, para cada conceito, têm que ser definidas regras que garantem a integridade do sistema como um todo. Caracteristicas específicas de sistemas complexos ativos e/ou reativos, questões de autonomia, aspectos espaciais e temporais, assim como informações imprecisas, devem ser levados em consideração.
abordagem informacional de conhecimento em Dretske
Authors: Salsmam Isabele Vieira , Alves Marcos Antonio
Published: March 2022

No limiar do século XX, a humanidade vivencia significativo avanço nas tecnologias de informação e de comunicação. Neste período, diversos campos do saber adotam como pano de fundo abordagens informacionais, em suas pesquisas, assumindo metodologias interdisciplinares, em suas investigações. Surgem novas disciplinas, como a Filosofia e Ética da Informação, buscando compreender, dentre outras coisas, o que é a informação, seu estatuto ontológico e epistemológico, seus efeitos nas ações humanas. Um dos problemas clássicos da filosofia, investigado com o auxílio dessas novas disciplinas, é o do conhecimento. Fred Dretske é um dos pensadores contemporâneos que o investiga sob um viés informacional, sugerindo uma definição com vistas a sanar as lacunas da abordagem tradicional. Para ele, conhecimento é crença causalmente sustentada por informação. Apresentamos, neste artigo, alguns dos aspectos da definição de conhecimento em Dretske. Para atingir esse fim, dividimos em três partes. Na primeira, tratamos do que envolve o conceito dretskiano de informação. Na segunda, apresentamos a definição de conhecimento desse autor e alguns elementos relacionados a ela. Por fim, na última parte, expomos algumas críticas direcionadas às suas noções de informação e conhecimento.
Tacit knowledge and a multi-method approach in Asset Management
Authors: Holanda Giovanni Moura de , Souza Jorge Moreira de , Adorni Cristina Y. K. Obata , Nader Marcos Vanine P. de
Published: March 2022

This paper has two main objectives. The first one is to reflect on the validity of data in analysis and projections that underpin the engineering asset management of organizations, considering, on the one hand, a certain resistance or even inadequate use of data and information of a subjective nature and; on the other hand, a consolidated reliance on quantitative approaches and decisions based on data series. The second objective is to contextualize the applicability of combining qualitative data based on experts’ experience and on the tacit knowledge built in organizations, with approaches based essentially on quantitative data, according to the data availability and the decision scenario over the asset life cycle. We present two application of an approach combining quali and quanti data. One example interrelates Statistics with Psychology and the other combines elicitated data about asset indicators with parameters deterministically calculated. Both applications aiming at providing more realistic indicators and supporting the Asset Management process to make more assertive decisions.
Computer-Aided Drug Design of Anti-inflammatory Agents Targeting Microsomal Prostaglandin E2Synthase-1 (mPGES-1)
Authors: dos Santos Nascimento Igor José , de Aquino Thiago Mendonça , da Silva Júnior Edeildo Ferreira
Published: March 2022

Inflammation is a natural reaction to external stimuli to protect the organism. However, if it is exaggerated, it can cause severe physiopathological damage, linked to diseases like rheumatoid arthritis, cancer, diabetes, allergies, and infections. Inflammation is mainly characterized by pain, increased temperature, flushing, and edema, which can be controlled using anti-inflammatory drugs. In this context, prostaglandin E2 (PGE2) inhibition has been targeted for designing new compounds with anti-inflammatory properties. It is a bioactive lipid overproduced during an inflammatory process, in which its increased production is carried out mainly by COX-1, COX-2, and microsomal prostaglandin E2 synthase-1 (mPGES-1). Recently, studies have demonstrated that mPGES-1 inhibition is a safe strategy for developing anti-inflammatory agents, which could protect against pain, acute inflammation, arthritis, autoimmune diseases, and different types of cancers. Thus, in recent years, computer-aided drug design (CADD) approaches have been increasingly used to design new inhibitors, decreasing costs and increasing the probability of discovering active substances. Finally, this review will cover all aspects involving high-throughput virtual screening, molecular docking, dynamics, fragment-based drug design, and quantitative structure-activity relationship in seeking new promising mPGES-1 inhibitors.
Biology, Significance and Immune Signaling of Mucin 1 in Hepatocellular Carcinoma
Authors: Nath Lekshmi R. , Kumar Ayana R. , Devan Aswathy R. , Nair Bhagyalakshmi , Nair Reshma Ravindran
Published: March 2022

Mucin 1 (MUC 1) is a highly glycosylated tumor-associated antigen (TAA) overexpressed in hepatocellular carcinoma (HCC). This protein plays a critical role in various immune-mediated signaling pathways at its transcriptional and post-transcriptional levels, leading to immune evasion and metastasis in HCC. HCC cells maintain an immune-suppressive environment with the help of immunesuppressive tumor-associated antigens, resulting in a metastatic spread of the disease. The development of intense immunotherapeutic strategies to target tumor-associated antigen is critical to overcoming the progression of HCC. MUC 1 remains the most recognized tumor-associated antigen since its discovery over 30 years ago. A few promising immunotherapies targeting MUC 1 are currently under clinical trials, including CAR-T and CAR-pNK-mediated therapies. This review highlights the biosynthesis, significance, and clinical implication of MUC 1 as an immune target in HCC.
Design, Synthesis, and Anti-Bacterial Evaluation of Tetrahydrobenzothiophene
Derivatives as Lipopolysaccharide Biogenesis Inhibitors
Authors: Chen Jun , Pei Shuchen , Yang Jinhua , Xia Shihao , Tang Shuting , Yuan Kangyao
Published: March 2022

Background:

Bacterial infections caused by multidrug-resistant bacteria have emerged as major
threats to human communities worldwide. There is a great need to develop new mechanisms by which
anti-bacterial agents can combat bacterial antibiotic resistance.

Objective:

This study aims to synthesize and characterize a series of novel tetrahydrobenzothiophene
derivatives and evaluate their anti-bacterial activities.

Method:

In this study, we have synthesized 2-benzamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-
carboxylic acid derivatives (3a-3r) and investigated their anti-bacterial activities against E. coli, P. aeruginosa,
Salmonella, and S. aureus.

Results:

The MIC values demonstrated that all synthesized derivatives possessed potent anti-bacterial
activity properties. Compounds 3b, 3e, 3f, 3g, 3h, 3n, and 3q exhibited in vitro excellent anti-bacterial
efficiency. Compounds 3b, 3e, 3f, and 3p were evaluated by in vitro time-kill assay; they displayed concentration-
dependent bacteriostatic effects. Compounds 3b, 3e, 3f, and 3p showed moderate water solubility,
high stability in plasma, and moderate acute oral toxicity.

Conclusion:

Most of the 2-benzamido-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carboxylic acid derivatives
exhibited potent anti-bacterial activities. The data reported in this paper may guide the design of tetrahydrobenzothiophene
derivatives.
When “Wait and See” may be the Best Option: Two Case Reports of Left
Main Artery Spontaneous Dissection
Authors: Castelo Alexandra , da Silva Tiago Pereira , Ramos Ruben , Mano Tânia Branco , Ferreira Rui Cruz
Published: March 2022

Introduction:

Spontaneous coronary artery dissection (SCAD) is frequently underdiagnosed,
and the most appropriate management is unknown, particularly in high-risk anatomical subsets.

Case Reports:

Two cases of females in their 60-70s with few cardiovascular risk factors or relevant
past medical history, who presented acute myocardial infarction, have been presented. Both
were submitted to invasive coronary angiography, with a suspicion of SCAD in both cases, which
was later supported by coronary computed tomography angiography (CCTA). They were managed
conservatively under close monitoring, with a favorable outcome. Repeated CCTA showed significant
improvement, and both patients remained asymptomatic and free from complications 6 and 12
months after the initial event.

Conclusion:

The recognition of spontaneous coronary artery dissection is essential for the correct
management of these cases because, unlike acute coronary syndrome due to atherosclerotic disease,
the results of revascularization in those patients are suboptimal and conservative management
is probably the best option, even in patients with high-risk anatomy.
WITHDRAWN: Original Antigenic Sin in COVID-19: Hoskins Effect and
Vaccine
Authors: Khan Mudassir , Manzoor Sobia , Ullah Najeeb , Khan Dilawar
Published: March 2022

The article has been withdrawn at the request of the authors.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Built Environment and Its Association with Depression among Older Adults: A Systematic Review
Authors: Sokale Itunu O. , Conway Sadie H. , Douphrate David I.
Published: March 2022

Background:

There is an increasing global quest to understand the influence of built environment (BE) on the mental health of people, particularly in later life. Older adults may be more susceptible to environmental factors than other adults for several reasons.

Objective:

The study aims to provide an overview and synthesis of the scientific literature on the relationships between built environment (BE) and depression among older people and examine possible rural-urban differences in the association.

Methods:

We conducted a systematic search for articles published in English from 2000-2018 in three electronic databases – PubMed, Cumulative Index to Nursing and Allied Health Literature (CINAHL), and PsycInfo. We used the Population, Exposure, Comparator, and Outcomes (PECO) framework to guide the search keywords’ development and inclusion and exclusion criteria. Studies examining associations between built environment attributes and depression were only included if they were original, peer-reviewed, reported at least one objectively measured built environment attribute, any type of depression as an outcome of interest, and the sample included people aged 50 or older.

Results:

Of 617 citations identified, 13 met our inclusion criteria. BE attributes assessed by studies varied; however, all studies reported a relationship between depression and at least one BE attribute. Four of six papers reported a protective association between green spaces and depression, while other BE attributes did not demonstrate a consistent association with depression.

Conclusion:

Adverse BE is related to depressive symptoms and should be considered in interventions targeted at preventing depression among older adults who are particularly vulnerable. Future studies focused on the relationship between the urban and rural built environment and depression among older adults are needed.
Impact of Social Media Infodemics on Mental Health among Health Colleges’ Students at Saudi Universities during COVID-19 Pandemic
Authors: Nour Mohamed O. , Sinky Tassnym H. , Natto Hatim A.
Published: March 2022

Background:

Saudi Arabia has been severely affected by COVID-19 since March 2020. The COVID-19 “infodemic” has spread a plethora of misinformation on social media leading to public panic and serious public health consequences. We aimed to investigate the impact of social media infodemics on mental health status among health colleges’ students, as future healthcare workers, at Saudi universities during the COVID-19 pandemic.

Methods:

We used a cross-sectional web-based survey to collect data from 400 health colleges’ students. We assessed average time spent on social media and used the shortened Pittsburgh sleep quality index, generalized anxiety disorder scale, and Center for Epidemiology scale for depression to measure sleep quality, generalized anxiety disorder, and depressive symptoms. Generalized linear regression was used to determine associations with mental health burdens.

Results:

About 21.5% reported more than 3 hours/day of exposure to social media. Prevalence of poor sleep quality, anxiety, and depression disorders was 16%, 31%, and 24%, respectively. No significant difference was determined between males and females (P>0.05); however, a significant association was detected with time spent on social media (P<0.001).

Conclusion:

We found a significant mental health burden among health colleges’ students during the COVID-19 pandemic. Spending too much time on social media is a potential risk factor. Controlling social media infodemics, early mental health interventions, and continuous monitoring of consequences should become routine as part of preparedness efforts.
A critique of the EIA Report selected from the East African region, taking into consideration what is required in an ideal of EIA Report
Authors: Bishoge Obadia Kyetuza , Mvile Benatus Norbert
Published: March 2022

At present, every country strives to realize development for its people. Therefore, to achieve this requires the construction of various projects for the realization of a country's socio-economic and political development. However, the development of the projects is associated with various ecological challenges that can have an impact on society as a whole and the environment. Therefore, there is a need to conduct an environmental impact assessment (EIA), a tool that can be used to determine the environmental, social and economic impacts of a project before making a decision. The EIA process is linked to the detailed report containing all possible environmental, social and health impacts after, during and after the project. Therefore, this paper aims to deliver the critique of one of the EIA reports in the East African region. To achieve this, EIA legislation and guidelines for preparing and verifying EIA reports in the East African region will be examined. The critique contains the issues that include the advisory team (environmental and social impact assessment team), an executive or non-technical summary, a description of the proposed project, a description of the development, the local environment and initial conditions, the political, legal and administrative framework, and public participation/stakeholder analysis in the EIA process.
Comparing Reminders Sent via SMS Text Messaging and Email for Improving Adherence to an Electronic Health Program: Randomized Controlled Trial
Authors: Kulhánek Adam , Lukavska Katerina , Gabrhelík Roman , Novák Daniel , Burda Václav , Prokop Jindřich , Holter Marianne T S , Brendryen Håvar
Published: March 2022

Background

eHealth interventions can help people change behavior (eg, quit smoking). Reminders sent via SMS text messaging or email may improve the adherence to web-based programs and increase the probability of successful behavior change; however, it is unclear whether their efficiency is affected by the modality of the communication channel.

Objective

A 2-armed randomized control trial was conducted to compare the effect of providing reminders via SMS text messaging versus email on the adherence to an eHealth program for smoking cessation and on the probability to initiate a quit attempt.

Methods

Smokers were recruited via an internet-based advertisement. A total of 591 participants who diverted from intended use of the program (ie, failed to log on to a session) were automatically randomized to the experimental (SMS text messaging reminder, n=304) or the active comparator (email reminder, n=287) group.

Results

Unexpectedly, we found that the mode of reminder delivery did not significantly affect either the adherence, namely the number of completed program sessions, with the SMS text messaging reminder group showing a mean of 4.30 (SD 3.24) and the email reminder group showing a mean of 4.36 (SD 3.27) (t586=0.197, P=.84, and Cohen d=0.016), or the outcome, namely the quit smoking attempt rate (34.2% in the SMS text messaging group vs 31.7% in the email group; χ21=0.4, P=.52). Secondary analyses showed that age, gender, and education had significant effects on program adherence and education on the outcome. Moreover, we found a significant interaction effect between the mode of reminder delivery and gender on program adherence, suggesting that the effectiveness of SMS text message reminders might be different for females and males. However, this particular finding should be treated with care as it was based on post hoc subgroup analysis.

Conclusions

This study indicates that the modality of user reminders to log on increased neither the program adherence nor the probability of quitting smoking. This suggests that program developers may save costs using emails instead of SMS text messaging reminders.

Trial Registration

ClinicalTrials.gov NCT03276767; https://clinicaltrials.gov/ct2/show/ NCT03276767