bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pengaruh Perkembangan Identitas Terhadap Intensi Turnover Dengan Mediasi Komitmen Karier Pada Karyawan Milenial Jabodetabek
Authors: Tedja Timothy , Sijabat Rosdiana
Published: August 2021

Tujuan penelitian ini adalah untuk mengetahui: 1) Pengaruh keberhasilan perkembangan identitas terhadap identitas karier, 2) perencanaan karier, dan 3) resiliensi karier, 4) Pengaruh identitas karier, 5) perencanaan karier, dan 6) resiliensi terhadap intensi turnover, 7) Pengaruh keberhasilan perkembangan identitas terhadap intensi turnover, serta pengaruh keberhasilan perkembangan identitas terhadap intensi turnover dengan (8) identitas karier, (9) perencanaan karier, dan (10) resiliensi karier sebagai mediasi. Responden diperoleh dengan metode sampling insidential. Penemuan dari riset ini adalah keberhasilan perkembangan identitas memiliki pengaruh positif terhadap identitas karier, perencanaan karier, dan resiliensi karier. Perencanaan karier dan resiliensi karier memiliki pengaruh positif terhadap intensi turnover. Keberhasilan perkembangan identitas memiliki pengaruh positif terhadap intensi turnover dengan mediasi perencanaan karier dan resiliensi karier. Kontribusi dari riset ini dapat memberikan masukan bagi organisasi-organisasi yang ada di Jabodetabek untuk mengurangi intensi turnover.
There are not any accepted forthcoming COVID-19 papers.
Authors: UTPJ
Published: August 2021

There are not any accepted forthcoming COVID-19 papers. Please go back to https://www.utpjournals.press/toc/cpp/COVID-19 and click on one of the other COVID-19 articles.
The Pivotal Role of PAO in CDK Inhibitors (Roscovitine and Purvalanol)- Triggered Apoptosis in PUMA Null HCT116 Colon Cancer Cells
Authors: Coker-Gurkan Ajda , Coker-Gurkan Ajda , Ayhan-Sahin Burcu
Published: August 2021

Background: Cycline-dependent kinase inhibitors (CDKi); roscovitine and purvalanol, are promising anti-cancer drugs due to their strong anti-proliferative effectiveness due to activation of PA catabolism. Besides
transforming acetylated spermine and spermidine into spermidine and putrescine, respectively, polyamine
oxidase (PAO) also generates hydrogen peroxide in high concentrations as a by-product. PAO was assumed
as a pivotal key molecule during drug-induced apoptosis in cancer cells. Our aim is to reveal the role of
PAO action in CDKi-triggered apoptosis in Puma knock-out HCT116 colon cancer cells.
Methods: HCT116 wt and HCT116 Puma-/-
cells were treated with Roscovitine and Purvalanol and cell
viability and apoptosis were determined. Protein was isolated from treated and untreated cells and key
molecules of cell cycle control and polyamine pathways were investigated at translational level. Polyamine
content was determined by HPLC for all conditions. MDL-72527 was used as a PAO inhibitor and apoptotic
cell death was analysed.
Results: Roscovitine and purvalanol induced apoptosis and increased the cytotoxic responses in HCT116
wt and HCT116 Puma-/-
colon carcinoma cell lines by modulating CDK1, 4, cyclin-B1, D3. Both, CDKi
altered intrinsic apoptotic pathways in HCT116 wt. Whereas, drug-induced apoptosis occurred caspase-independent in Puma-/-
colon cancer cells. Roscovitine and purvalanol up-regulated polyamine catabolic
enzymes, whereas CDK inhibitors decreased the polyamine levels in HCT116 wt and HCT116 Puma-/-
colon
cancer cells. In addition, PAO inhibitor MDL72527 prevented drug-induced apoptosis.
Conclusion: PAO expression profile might be a critical target in CDK inhibitors-triggered apoptosis in
HCT116 colorectal cancer cells. Thus, MAPK signaling pathway relations with cell cycle and polyamine
catabolic pathway investigations are in progress.
A CASINHA DE VILANOVA ARTIGAS COMO SÍMBOLO DEMOCRÁTICO DO PATRIMÔNIO MODERNISTA PAULISTANO
Authors: Schmitz João Vicente Machado , Johann Maria Regina
Published: August 2021

O presente artigo tem como objetivo apresentar a Casinha de João Batista Vilanova Artigas, um de seus mais relevantes trabalhos no cenário modernista da arquitetura paulistana, permeando sob a perspectiva técnica e política. O período de concepção da obra foi revolucionário em questões construtivas, funcionais e plásticas. O Brasil vivera um período de resistência artística; 1922 trouxe inúmeras discussões sobre a arte moderna que estava sendo importada e reformulada. Com isso, mesmo duas décadas mais tarde, o país se mostrava rígido arquitetonicamente, contando com poucas referências externas em pauta à arquitetura moderna - essa que, por sua vez, estava sendo estudada e difundida mundo afora. Acrescenta-se, nesse ponto, o caráter progressista de Artigas a partir de seus estudos, principalmente pela influência de Frank Lloyd Wright, que vinha mudando o cenário construtivo norte americano. É evidenciado, ainda, a natureza política de Artigas que, a partir da década de 1940, trouxe significativas memórias pelas quais o engenheiro-arquiteto ainda é reconhecido. A partir disso, coloca-se a primeira residência do arquiteto não somente como uma edificação de grande importância no cenário arquitetônico nacional, mas como um refúgio e espaço de deliberações de Artigas, de seus amigos e alunos
Clinicopathological Factors that Predict Endocervical Margin Involvement of CIN2+ after Cervical Conization Procedure in the Tertiary Center, Rajavithi Hospital, Thailand
Authors: Tientong Kamaitorn , Yanaranop Marut , Wannatrakool Nattharwan
Published: August 2021

Objective: To identify clinicopathological factors that predict endocervical margin involvement of CIN2+ after cervical conization. Methods: 464 patients undergoing LEEP at Department of Obstetrics and Gynecology, Rajavithi Hospital, Thailand between January 2014 and June 2019 were analysed retrospectively. The patients were divided into two groups as a negative and positive endocervical margin of CIN2+. Clinical factors and the cyto-pathological characteristic were included. Univariate and multivariate analysis were used to identify the risk factors predicted positive endocervical margin. Results: 150 (32.3%, 150/464) women had endocervical margin involvement of CIN2+. Mean age in positive endocervical margin group was significant older than negative endocervical margin group (47.8 ± 12.9 versus 40.8 ± 11.5 years old, p <0.001). There are more significant post-menopausal women in positive endocervical margin group (p<0.001). In positive endocervical margin group, there were significant higher grade on cervical cytology, higher grade on histology of LEEP specimen, and glandular involvement of LEEP specimen. In univariate analysis, age of ≥ 50 years old, post-menopausal status, ≥ HSIL on cervical cytology, and glandular involvement of LEEP specimens were independent risk factors for predicting endocervical margin involvement. Moreover, in multivariate analysis, age of ≥ 50 years old and glandular involvement of LEEP specimen show significant difference between two groups. In endocervical margin involvement of CIN2+ group has 2.84 (95% CI: 1.23-6.56, p = 0.015) and 2.41 (95% CI: 1.58-3.66, p <0.01) times more age ≥ 50 years old and glandular involvement of LEEP specimen respectively. Conclusions: The age of ≥50 years old is the only pre-operative variable in this study. This finding is consistent with many previous studies. Therefore, performing LEEP in the women with the age of ≥50 years old should be aware the result of positive endocervical margin
Role of Computed Tomography in the Evaluation of Pediatric Retroperitoneal Masses: A Retrospective Study
Authors: Vikrant Gupta , Deepak Abrol
Published: August 2021

Objective: Retroperitoneum is one of the largest spaces in the body. Retroperitoneal (RP) masses are common in paediatric age group and present with vague clinical features. Computed Tomography (CT) is an excellent imaging modality in the evaluation of RP masses. The aim of this study was to evaluate the role of CT in the detection and characterization of RP masses. Materials and Methods: 28 clinically suspected or sonographically detected RP masses formed the material of the study. Detailed clinical history was elicited from the patients/attendants and findings of general physical examination recorded. Non-contrast and Contrast Enhanced CT was performed and masses were evaluated with respect to site of origin, consistency, components and pattern of enhancement. Probable CT diagnosis was made and findings correlated with pathological/laboratory findings wherever possible. The results were subjected to statistical analysis and expressed as percentages and proportions.Results: Majority of patients were seen in 1-5 years age group with M:F ratio of 1.8:1. Lump abdomen was the commonest presenting feature followed by pain abdomen. Lymph nodal masses were the commonest primary RP space mass while renal masses accounted for the majority of secondary RP masses in our study. Pathological/Laboratory correlation was available in 21 cases and CT was able to differentiate benign and malignant lesions in 95.2% cases. Overall diagnostic accuracy of CT in the evaluation of RP masses was 85.7%. Conclusions: CT is a simple and reliable tool in diagnosing pediatric RP masses with a high diagnostic accuracy.
Memorial Crosses of Veliky Novgorod: The Cross of Venerable Savva Vishersky and the Wander or the Black Cross
Authors: Игошев Валерий Викторович
Published: August 2021

В статье исследуются деревянные поклонные кресты работы новгородских мастеров, которые устанавливались для поклонения и в память каких-либо значимых событий. На основании изучения истории бытования, типологии, стилистических и технико-технологических особенностей сохранившегося в Новгородском музее креста Саввы Вишерского и утраченного Чудного (Чёрного) креста выявлены разновременные части этих памятников и сделана их атрибуция. В результате исследования деревянного креста Саввы Вишерского установлено, что памятник является сложным и разновременным, в основе которого сохранилась древняя массивная часть креста, сделанная в 1417 г. при основании монастыря самим преподобным Саввой Вишерским. А рельефные изображения и надписи вырезаны в конце XV - начале XVI в. после кончины преподобного. Вероятно, разновременным памятником был также и Чудный (Чёрный) крест. Его более тонкая лицевая поверхность, вероятно, изготовлена во время «поновления» или «реставрации» в 1547 г. Она была надставлена из липовых досок, и затем на этой плоскости вырезаны рельефные изображения Распятия, предстоящих и надписи. Скорее всего, при таком «поновлении» форма и пропорции древнего особо почитаемого восьмиконечного креста не были изменены.

The article explores two wooden memorial crosses, the work of Novgorod masters, which were erected for worshiping and in memory of a certain significant events. Based on the history study, typology, stylistics and technological features of the Savva Vishersky cross, which is currently preserved in the Novgorod Museum, and now lost The Wonder (or The Black) Cross a different part of these objects were studied and attribution was made. As a result of the study of the Savva Vishersky wooden cross it was established that the object is complex and multi-temporal. There is an ancient massive part in the core of the cross, which was originally made by venerable Savva Vishersky himself in 1417 at the time of the monastery foundation. Relief images and inscriptions were carved in the late 15th or early 16th centuries already after the death of the reverend. Quite possible that the Wonder (or Black) Cross was also a multi-temporal as a finer frontal surface was probably made during a renovation in 1547. The frontal surface was created with Linden wood boards and then Crucifixion images, Saints and the inscriptions were carved out. Most likely this renovation did not influence the form and proportions of the ancient and highly revered eight-pointed cross.
Vasily Surikov’s Time (Reflection on the Spiritual Challenges of the Era)
Authors: Блохин Владимир Владимирович
Published: August 2021

В статье рассматривается идейно-культурный контекст творчества В. И. Сурикова. Его художественная деятельность пришлась на период религиозного кризиса, который наиболее полно проявился в сознании российской интеллигенции во второй половине XIX в. В статье показано, что идейные вожди пореформенной интеллигенции (А. И. Герцен, М. Бакунин, Л. Толстой) активно формировали среду богоборчества. Творчество Василия Сурикова, напротив, изначально было наполнено глубоким христианским смыслом, питалось всей атмосферой его жизни и деятельности. Православие стало органичной чертой его жизни. В отличие от интеллигенции и её типичного взгляда на народ, Суриков глубоко и жизненно выразил стихию народной жизни. Размышляя о творчестве художника, не трудно заметить, что в его духовно-эстетической концепции проявляются три основных тематических пласта: православие, народность, историзм.

The article examines an ideological and cultural context of V. I. Surikov’s work. His artistic activity fell on a period of religious crisis manifested most fully in the minds of the Russian intellectuals in the second half of XIX century. The article shows that ideological leaders of the post-reform intelligentsia (A. I. Herzen, M. Bakunin, L. N. Tolstoy) actively formed an environment fighting against God. Vasily Surikov's work, on the contrary, was initially filled with a deep Christian meaning, nourished by the traditional atmosphere of his life and work. Orthodoxy became an organic feature of his life. In contrast to the popular ideas of the time and its typical view of the people, Surikov deeply and vitally expressed an element of people's life. Reflecting on the artist's heritage, it is clear to see three main basic themes of his work that manifest his spiritual and aesthetic concepts. There are Orthodoxy, nationality, historicism.
En absoluto como elemento de negación
Authors:   Universidad de Alicante, Cifuentes Honrubia José Luis
Published: August 2021

En este trabajo analizamos la construcción en absoluto como palabra negativa. Consideraremos
fundamentalmente dos valores de la misma: su valor discursivo como respuesta negativa, y su
valor oracional en concordancia negativa no estricta. A partir del análisis de todos los
ejemplos suministrados en el CDH y en el CORPES XXI para la forma en absoluto, daremos cuenta de
los significados y características formales de la construcción. Analizaremos también su
evolución desde valores positivos a refuerzo totalizador de la negación y su consideración como
palabra negativa dentro del ciclo de Jespersen.
Intelligent firm as a new kind of economic organization
Authors: Suharev Oleg
Published: August 2021

The article spotlights the features of the intellectual firm, which determine both a change in theoretical concepts of the classical theory of the firm, and changes in management practices. Though the classical firm possesses intelligence, it may not be considered as an intellectual firm, the main attribute of which is the ability to generate intelligence, and not just use it. The author shows the contingency in the development of the theory of the intellectual firm and examines the intellectual firm itself as an institutional innovation. He also identifies various modes of change in intelligence and knowledge that affect the possibility of describing a company from the standpoint of knowledge production and accumulation of intelligence.
The ideas about the intelligence of the firm and the prospects of the theory of the intellectual firm, arising from the theory of the knowledge-intensive firm, are clarified. The future of the development of the theory of the intellectual firm is seen in linking the work of intelligence with alternative options for choosing decisions, tactical and strategic in nature, made in the firm on a daily basis.
Selected DHS data on 10–14-year-olds: Comoros
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
Selected DHS data on 10–14-year-olds: Dominican Republic
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
Selected DHS data on 10–14-year-olds: Jordan
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
Selected DHS data on 10–14-year-olds: Mozambique
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
Selected DHS data on 10–14-year-olds: Namibia
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
Selected DHS data on 10–14-year-olds: Niger
Authors:   Population Council
Published: August 2021

Annex to "Facts about adolescents from the Demographic and Health Survey—Statistical tables for program planning"
„Dann machen halt alle mit.“ Eine qualitative Studie zu Beweggründen und Motiven für Hatespeech unter Schüler*innen
Authors: Ballaschk Cindy , Wachs Sebastian , Krause Norman , Schulze-Reichelt Friederike , Kansok-Dusche Julia , Bilz Ludwig , Schubarth Wilfried
Published: August 2021

Das Thema Hatespeech rückt immer mehr in den Fokus der Öffentlichkeit und der Forschung. Im Gegensatz zu Hatespeech im Internet wird jedoch Hatespeech unter Jugendlichen, die von Angesicht zu Angesicht im Schulkontext ausgeübt wird, kaum beachtet. Hier setzt die vorliegende Studie an, in der Schüler*innen (n = 55), Lehrkräfte (n = 18) und Sozialpädagog*innen (n =16) auf der Basis leitfadengestützter Interviews dazu befragt wurden, was mögliche Beweggründe und Motive dafür sind, dass Schüler*innen Hatespeech in der Lebenswelt Schule und online ausüben. Die Ergebnisse zeigen, dass mögliche Beweggründe für Hatespeech Angst vor Statusverlust, Gruppendruck, Provokation, Spaß, politischideologische Überzeugung und Kompensation von Frust- und Minderwertigkeitsgefühlen sind. Darüber hinaus wird verdeutlicht, dass sich hinter diesen Gründen für Hatespeech oftmals Grundmotive nach Macht und Zugehörigkeit abzeichnen. Die Ergebnisse werden in Bezug auf anschließende Forschung und praktische Implikationen diskutiert.
Supralevator Abscess Complicated by Necrotic Fasciitis of Peritoneum, Genitalia, Anterior Abdominal Wall and Retroperitoneum.
Authors: Hadzhieva Elena , Chakarov Dzhevdet , Moshekov Evgenii , Hadzhiev Dimitar , Kalchev Yordan , Atliev Kiril , Sakakushev Boris
Published: August 2021

A supralevator anorectal abscess may lead to a rare clinical complication, such as perineal necrotizing fasciitis. A 57-year-old man was admitted on an emergency basis with evidence of a deep anorectal abscess of 5-day duration. The clinical presentation involved an unbounded purulent destructive inflammation spreading onto the adjacent areas, with the development of a septic condition. Following a short preparation, a radical surgical debridement of a subfascial purulent necrotic phlegmon of the pelvic space was performed. Since the lower part of the abdomen, retroperitoneum and scrotum were involved, 4 additional subsequent necrectomies were performed at 48-hour intervals. The aggressive radical operative treatment and the combined intensive therapy were the main contributors to the favorable outcome of the disease.
Design and development of prototype electric fence energizer
Authors: Tenzin Namgay , Chapagai Kamal Kr. , Dorji Cheku , Dukpa Nima
Published: August 2021

A research project was carried out to design and develop an electric fence energizer that is energy efficient, robust, and effective. An experimental-based applied research project was being developed and carried out under the aegis of Centre for Renewable and Sustainable Energy Development, College of Science and Technology (CST), Phuenthsoling, Bhutan. Two models were designed and developed for laboratory and field tests; one based upon Zero Voltage Switching (ZVS) high impedance-based energizer and another with a low impedance-based energizer. Extensive simulations and laboratory testings were carried out for both models. The field tests were also carried out at CST, Genekha, and Begana in Thimphu, Bhutan. From the analysis, it was observed that both the models would work as designed if the fence is ideal (Infinite Impedance between fence and ground). The ideal fence is not possible in reality, there will be some faults, therefore the impulse output voltage of the ZVS based energizer falls to as low as 2.2 kV with which the electric fence becomes ineffective which was observed in the field tests conducted at Genekha and Begana, Thimphu, Bhutan. Therefore, a second model was designed based on the low impedance drive system, which would not require an ideal fence. The field tests conducted at CST showed that the impulse output voltage was 7 to 8kV for 1.5 seconds against a design rating of 14 kV even when the fence was faulty. For both, the models designed the maximum energy output is 2.5 joules. Further detailed laboratory and field tests are required to validate and ascertain the robustness of the designed model.
Informe de la Junta Directiva al Congreso de la República - Julio de 2021
Authors: Restrepo José Manuel , Soto Losada Carolina , Steiner Sampedro Roberto , Villamizar Villegas Mauricio , Taboada Arango Bibiana , Jaramillo Vallejo Jaime
Published: August 2021

La Junta Directiva del Banco de la República, de conformidad con lo previsto en el artículo 5° de la Ley 31 de 1992, presenta a consideración del honorable Congreso de la República su Informe al Congreso en el cual se detallan las medidas que ha tomado el Banco de la República en el marco de la emergencia generada por el Covid-19 y se presentan los resultados macroeconómicos del primer semestre de 2021 y las perspectivas para lo que resta del año. Adicionalmente, se describe la composición de las reservas internacionales y su rendimiento, la situación financiera de la Entidad y sus proyecciones, y la evolución de los pagos en la economía colombiana.
Implementasi Teori Belajar Humanisme dalam Proses Belajar Mengajar Pendidikan Agama Islam
Authors: Diana Devi Aulia
Published: August 2021

The process of educating a child must pay attention to the right theory so that children can absorb and receive lessons, and can apply them well. This study aims to describe the learning theory of humanism in learning Islamic religious education. This study uses a qualitative method with a literature study format. The results of this study indicate that the implementation of humanism learning theory in Islamic education is evidenced by several facts, namely, learning  conditions, student conditions, and the existence of activities that support the application of the concept of humanism learning. This implementation can also produce active learning, one ofwhich is the discussion and presentation method, which aims to train the independence and courage of students to express their opinions. Community social activities, which aim to train students' socialization and empathy for their environment. Mentoring and coaching, which aims to shape the character and improve the morals of students, reduce juvenile delinquency, and improve student achievement.
DAYA HAMBAT PERASAN JERUK NIPIS (Citrus aurantifolia) TERHADAP PERTUMBUHAN BAKTERI Enterococcus faecalis
Authors: Aryanto Mirza
Published: August 2021

Perawatan saluran akar merupakan salah satu perawatan endodontik untuk mempertahankan gigi dengan bagian jaringan pulpa yang sudah terinfeksi bakteri. Irigasi saluran akar merupakan salah satu proses yang sangat penting untuk mengeliminasi bakteri dalam saluran akar. Pada saluran akar gigi dengan perawatan endodontik yang gagal ditemukan bakteri Enterococcus faecalis, sehingga diperlukan alternatif bahan irigasi yang lebih efektif. Tujuan : Menjelaskan daya hambat perasan jeruk nipis (Citrus aurantifolia) sebagai bahan alternatif larutan irigasi dalam menghambat pertumbuhan bakteri Enterococcus faecalis pada perawatan saluran akar. Bahan dan Metode : Sampel yang diuji berjumlah 32 berupa biakan bakteri Enterococcus faecalis dalam media agar BHI pada cawan petri. Penelitian ini menggunakan metode difusi cakram kertas. Setiap 1 cawan petri dibagi menjadi 4 bagian dan diletakkan cakram kertas yang masing-masing telah diberikan perasan jeruk nipis (Citrus aurantifolia) kosentrasi 100 % dan kontrol positif (NaOCl 2,5%). Bakteri ditanam dan diinkubasi, kemudian diencerkan dengan standar konsentrasi bakteri McFarland I (1.10 6 cfu/ml). Hasil Penelitian : Besar rerata daya hambat bakteri Enterococcus faecalis dalam perasan jeruk nipis (Citrus aurantifolia) sebesar 5,8 1,8 mm, sedangkan pada larutan NaOCl 2,5% sebesar 3,9 1,1 mm. Uji hipotesis memiliki nilai p = 0,000 (p 0,05). Kesimpulan : Perasan jeruk nipis (Citrus aurantifolia) memiliki daya hambat bakteri Enterococcus faecalis yang lebih efektif.
SUPPORT OF EDUCATION IN CYBERSECURITY
Authors: Bolun Ion , Bulai Rodica , Ciorbă Dumitru
Published: August 2021

Cybersecurity depends heavily on education. The paper addresses the support of education as the smartest investment in cybersecurity. To define priorities, an early estimate of the state of cybersecurity in Moldova by an online survey has been completed. A wide range of aspects related to cybersecurity education are  elucidated within three basic periods: initial (school), transit (university) and  reinforcement (implementation and use at workplace). Referred to in these are: formation of an ‘informational’ culture, target professions, curricula content,  competences, cooperation with companies, digital education, e-learning platforms,  information services, risks associated with human resources, etc. Also, conceptual  aspects regarding the creation of a cybersecurity polygon in support of training in  the field are described: basic objectives, main functions, structural components,  the technological platform and methodological issues of creating the system of  cybersecurity models for application as needed.
Gambaran Pengetahuan Mahasiswa S1 Keperawatan STIKES Muhammadiyah Gombong tentang Obat Generik
Authors: Handayani Eka Wuri , Intiyani Rafila
Published: August 2021

Pengetahuan yang dimiliki seorang mahasiswa keperawatan tentang obat generik merupakan salah satu bekal yang harus dimiliki sebelum terjun di dunia kerja. Obat generik merupakan obat yang tidak disalut dan tidak dikemas dengan menarik karena ada syarat dan ketentuannya, sehingga rasanya murni obat. Obat generik memiliki kesamaan dengan obat paten mulai dari bahan aktif dalam kandungannya, kegunaan kekuatan, formulasi, dosis, kualitas, dan keamanan. Tujuan dari penelitian ini yaitu untuk mengetahui bagaimana tingkat pengetahuan mahasiswa S1 Keperawatan STIKES Muhammadiyah Gombong tentang obat generik. Penelitian ini menggunakan desain cross sectional untuk mengetahui gambaran tingkat pengetahuan mahasiswa S1 Keperawatan STIKES Muhammadiyah Gombong tentang obat generik. Penelitian ini dilakukan pada bulan Februari dan Maret 2020. Teknik pengambilan sampling menggunakan purposive sampling diperoleh jumlah 85 responden. Instrument yang digunakan untuk pengumpulan data berupa kuesioner tingkat pengetahuan mahasiswa tentang obat generic dan dianalisa univariate untuk mengetahui deskripsi frekuensi dari tingkat pengetahuan mahasiswa tentang obat generik. Mayoritas tingkat pengetahuan mahasiswa S1 Keperawatan STIKES Muhammadiyah Gombong, Kebumen, Jawa Tengah tentang obat generik dalam kategori tingkat pengetahuan yang kurang yaitu pada 54 mahasiswa (63,5%). Harapannya hasil penelitian ini dapat memberikan gambaran terkait kondisi kurangnya pengetahuan mahasiswa terkait obat generik, sehingga dosen dan lembaga pendidikan dapat membuat kebijakan untuk lebih menambah materi pengenalan atau wawasan khusunya tentang obat generik kepada para mahasiswanya.
Uji Kandungan Fitokimia dan Aktivitas Antibakteri dari Ekstrak Etanolik Bawang Dayak terhadap Bakteri Staphylococcus Aureus dalam Media Mueller Hinton Agar
Authors: Supriani Supriani , Nurwijayanti Nurwijayanti
Published: August 2021

Infeksi merupakan penyakityang disebabkan oleh bakteri. Antibakteri adalah zat yang dapat mengganggu pertumbuhan atau bahkan mematikan bakteri.Bawangdayak telah dilaporkan mengandung senyawa yang memiliki kemampuan sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui kandungan fitokimia dan uji aktivitas antibakteri dari ekstrak etanolik bawang dayak terhadap bakteri Staphylococcus aureus dalam media Mueller Hinton Agar (MHA).Metode:Metode yang digunakan untuk ekstraksi bawang dayak adalah maserasi, dengan pelarut etanol 96%. Ekstrak etanolik yang diperoleh diuji kandungan fitokimia dan aktivitas antibakteri terhadap bakteri Staphylococcus aureusdengan teknik disk diffusion.Hasil penelitian menunjukkan, kandungan fitokimia yang terdapat pada ekstrak etanolik bawang dayak mengandung golongan senyawa flavonoid, kuinon, polifenol, steroid, dan tannin. Ekstrak etanolik bawang dayak memiliki aktivitas antibakteri sedang dengan efektivitas yang rendah (<50%). Konsentrasi ekstrak etanolik bawang dayak 8% memiliki aktivitas antibakteri paling baik dengan rata-rata sebesar 6,94 mmdibandingkan dengan konsentrasi 4% dengan rata-rata 5,242 mm dan konsentrasi 6% sebesar 6,28 mm dilihat dari perhitungan efektivitas antibakteri.
Pengalaman Psikologis Stres Pasien Kanker Serviks: Studi Fenomenologi
Authors: Distinarista Hernandia , Wuriningsih Apriliyani Yulianti , Laely Anna Jumatul
Published: August 2021

Pasien kanker membutuhkan pelayanan, perawatan secara holistic, dan informasi sesuai dengan konsep WHO yaitu kesehatan terdiri dari kesejahteraan fisik, psikis, sosial, dan spiritual (bio-psiko-sosio-spiritual), dengan demikian diharapkan perawat dapat memberikan perawatan kepada pasien kanker baik dari segi fisik, psikis, sosial, dan spiritual. Informasi berbasis bukti dibutuhkan oleh pasien kanker agar dapat menjalani pengobatan berkualitas dengan maksimal dan dapat  menjalani kehidupan dalam jangka panjang. Dalam memberikan pelayanan asuhan keperawatan secara holistik, perawat harus memiliki data dasar sebagai acuan dengan harapan pasien tidak hanya mendapatkan perawatan terkait keluhan fisik saja tetapi kebutuhan psikis pasien juga terpenuhi. Tujuan penelitian ini adalah untuk mengetahui gambaran kondisi psikologi pasien kanker serviks. Sehingga perawat dalam memberikan asuhan keperawatan memiliki acuan dasar dalam  memberikan perawatan secara holistic. Penelitian ini menggunakan metode fenomenologi hermeneutic, melibatkan 10 partisipan kanker serviks di RSUP Dr. Kariadi Semarang. Pengambilan data menggunakan teknik wawancara terstruktur dilanjutkan dengan melakukan transkripsi data. Penelitian ini menggunakan content analisis. Pada penelitian ini didapatkan 5 tema, yaitu: takut, sedih, kecemasan, harga diri rendah, dan depresi. Hasil penelitian ini menunjukkan bahwa pasien kanker serviks mengalami stress berat ditandai dengan beberapa keluhan yang disampaikan oleh pasien. Kesimpulan: Pasien kanker serviks mengalami stress karena ketakutan akan kanker itu sendiri, ketidakpastian tentang masa depan mereka, kesulitan yang mungkin dihadapi terkait psikologis, social, spiritual dan masalah emosional yang timbul dari kanker yang diderita pasien.
Aplikasi Meditasi terhadap Perubahan Tekanan Darah pada Pasien Hipertensi
Authors: Making Maria Agustina , Israfil Israfil , Nurwela Trifonia Sri
Published: August 2021

Hipertensi merupakan salah satu penyakit kronis yang biasa disebut silent killer, dimana dampak penyakit tersebut adalah stroke, penyakit jantung bahkan kematian. Ada juga dampak psikologis yang terjadi pada pasien yang mengalami hipertensi adalah stress maka untuk mengatasi masalah tersebut dapat diberikan terapi meditasi. Meditasi adalah cara untuk mengurangi respon stres dengan teknik relaksasi. Tujuaannya untuk mengetahui efektifitas tindakan meditasi terhadap perubahan tekanan darah. Penelitian tersebut menggunakan design non randomized control group pretest posttest design dengan 20 responden yang dipilih secara purposive sampling. Analisa data penelitian dengan teknik mann-whitney. Pada penelitian menunjukkan bahwa tekanan darah sistolik pada uji statistik menunjukkan bahwa p = 0,004 (p> 0,05) dengan nilai Z- 2945 artinya bahwa Ha diterima atau ada perbedaan tekanan darah antara sebelum dan sesudah terapi meditasi terdapat perubahan yang signifikan. Tindakan meditasi efektif membantu tubuh dalam menguatkan merilekskan otot-otot, sistem peredaran darah dan sistem pernafasan, menenangkan dan relaksasi sehingga mengakibatkan adrenalin dalam tubuh menurun, detak jantung (HR) menurun serta otot-otot di dinding pembuluh darah mengendur (vasodilatasi) sehingga tekanan darah menurun.
ЕНЕРГЕТИЧНА ПОЛІТИКА ПОЛЬЩІ ДО 2040 Р.: ОСНОВИ, ЦІЛІ ТА КЛЮЧОВІ ЕЛЕМЕНТИ
Authors: Паламарчук Дмитро , Паламарчук Наталія
Published: August 2021

В статті досліджено особливості трансформації енергетичної політики Польщі, що ґрунтується на проведенні суцільної трансформації в енергетичній сфері, залученні всіх зацікавлених сторін у процеси розвитку енергетичної політики, модернізації та інноваційному оновленні енергетичної сфери, стимулювання економічного розвитку, ефективності та конкурентоспроможності як основи для економічного зростання. Особлива увага відведена аналізу енергетичної політики Польщі до 2040 р. Зокрема, в статті проаналізовано основи енергетичної політики: справедлива трансформація, система нульових викидів енергії, висока якість повітря. Також розглянуто цілі та стратегічні проекти, ключові елементи та основні цільові показники енергетичної політики Польщі. Окрема увага приділена регіональним особливостям енергетичної політики, а також механізму її фінансування.
Nueva especie de ácaro del género Phyllozetes Gordeeva, 1978 (Acari: Oribatida: Cosmochthoniidae) de Coahuila, México
Authors:   Universidad Nacional Autónoma de México, Ojeda Margarita , García Leonardo , Páez Jair , Palacios-Vargas José G.
Published: August 2021

Se describe Phyllozetes aldretei sp. nov. un ácaro cosmoctónido de suelos oligotróficos en el Desierto Chihuahuense de México. Esta nueva especie se diferencia del resto de sus congéneres por poseer las sedas rostrales birrámeas, con sus ramas bifidas, en forma de “V” y conectadas por una membrana hialina. Adicionalmente, la combinación de sedas eréctiles de las líneas e y f con numerosas y largas barbulaciones marginales, distancia entre las sedas d1-d2 menos del doble que la d1-d1, y la fórmula coxiesternal 3-3-3-4 son caracteres diagnósticos de la nueva especie.
Research Capabilities of Public Secondary School Teachers in the Schools Division of Zambales
Authors: Farin Elizabeth N. , Brade Wilma M. , Garcia Cherry E.
Published: August 2021

The study aimed to assess the research capability of public secondary school teachers in the Division of Zambales and utilized a descriptive research design with a questionnaire as the main instrument in gathering data from seven hundred (700) teacher-respondents who were randomly selected. The researcher found out that the respondent is a married female Teacher-I in her early adulthood, with 21-25 hours of teaching load, baccalaureate degree holder had no research conducted and published but had attended a school-based seminar on research with knowledge on basic computer applications.  The respondents were assessed "moderately capable" of writing a research proposal and writing a research report. There is significant differences in civil status, academic rank, specialization, number of seminars attended, number of research published, and the level of computer literacy towards writing research proposal while the significant difference in age, specialization, number of seminars attended number of research published, and the level of computer literacy towards writing a research report. There is a slight or weak relationship between the number of research conducted and the research capability and a negligible relationship between the number of seminars attended and the research capability as to writing a research proposal and writing a research report.
Intensitas Serangan Hama Dan Patogen Pada Bibit Tembakau (Nicotiana tabaccum L.) Di Dinas Pangan Pertanian Kelautan Dan Perikanan Kota Langsa
Authors: Harlita Harlita
Published: August 2021

Tanaman tembakau merupakan salah satu komoditas andalan Indonesia yang berperan penting dalam penyediaan lapangan pekerjaan, sumber pendapatan bagi petani, dan sumber devisa negara bagi negara. Namun akhir-khir ini produktivitas mengalami penerunan yang di sebabkan serangan hama, patogen, gulma, dan faktor lingkungan. Tujuan dari penelitian ini yaitu mengetahui jenis hama dan patogen yang menyerang pada fase pembibitan tembakau, mengetahui persentase serangan hama dan patogen dan mengetahui cara pengendalian hama dan patogen pada pembibitan tembakau di Dinas Pangan Pertanian Kelautan dan Perikanan Kota Langsa. Metode yang digunakan pada penelitian ini  yaitu metode diskriptif kuantitatif dengan mengidentifikasi dan mengitung persentase dan insentisitas serangan hama dan patogen yang menyerang tanaman tembakau di pembibitan Dinas Pangan Pertanian Kelautan dan Perikanan Kota Langsa. Berdasarkan hasil penelitian terdapat dua jenis hama dan patogen yang menyerang tanaman tembakau pada fase pembibitan yaitu ulat daun (Spodoptera litura) dan jamur (Phytophthora nicotianae). Intensitas serangan hama dan patogen tertinggi pada hari ke-1 pengamatan terdapat pada Plot ke-I yaitu 0,25 % dan 0, 56 %, sedangkan terendah pada Plot ke IV yaitu  0,12 dan 0,25%. Namun, pada hari ke 15 setelah aplikasi fungisida nordox 70 ml/14 liter air dan insektisida decis 2,5 gr/15  intensitas serangan hama dan patogen mengalami penurunan yang signifikan. Dengan demikian fungisida nordox dan insektisida decis efektif mengendalikan hama dan patogen yang menyerang tanaman tembakau pada fase pembibitan.
Modern routines
Authors: Nuria Gil Mariño Cecilia , Kelly-Hopfenblatt Alejandro , Kriger Clara , Moguillansky Marina
Published: August 2021

The renewal of theoretical and methodological tools, putting the spotlight of film historiography on movie audiences and their movie-going routines, has meant a significant shift for the study of national and regional cinemas. The New Cinema History movement has demonstrated the vital importance of introducing in-depth, data-based studies of exhibition, distribution and programming, considering both individual and collective experiences. One trend in this renewal of cinema history are studies that rely on oral testimonies of the elderly to reconstruct their movie-going practices. This article discusses the ways spatial and temporal perceptions appear in oral narratives of movie-going experiences in Buenos Aires during the 1940s and 1950s. Based on twenty qualitative interviews with elderly men and women who attended cinemas during that period, we explore how through their imaginaries they build a certain place in the past that shows sharp contrasts to the perceived present. We trace the ways in which memories are intertwined with the emergence of modern routines in their environment and the way the cinematographic experience affected the audience’s mental cartography of the different environments of Buenos Aires. Film consumption, which included not only going to the pictures but also a constant presence of its imaginaries in their daily life, led them to develop new sensorial skills, helping them face a changing world.
Filmgoing or cinemagoing? The role of the film text within cinema memory
Authors: Terrill Jamie
Published: August 2021

Drawing upon original ethnographic research of rural Welsh audiences, this article meets a burgeoning trend within cinema history studies of reconsidering the importance that film texts can have in benefitting our understanding of social or cultural past. Arguing a perceived separation between the approaches of the New Film History and New Cinema History, the author highlights the benefits of incorporating text-based foci into his research, prompted by a notable separation between those that recalled the social environment of the cinema and those who discussed films, with little crossover between the two. With a dataset that largely recollects the late-1950s and 60s, these fresh textual considerations prompt modifications to existing scholarship pertaining to Britain’s previous generation of cinema audiences, highlighting a particularity of period that primarily revolves around the emergence of pop-stars and the teenage subculture. Equally, cultural factors such as a rising sentiment of Welsh nationalism are explored through film centred memories and textual analysis, highlighting the vivid semiotics and structures of Welsh national identity. These nuances of Welsh national identity and strengthened feelings of nationalism from the recollected period are explored through analysis of How Green Was My Valley, a US production, and its somewhat counterintuitive popularity with respondents as a “Welsh” film.
A Study on Peripheral Neuropathy and Its Related Risk Factors Associated With hba1c Levels
Authors: Hossain MA , Sarkar MK , Mahbub I , Islam SMS
Published: August 2021

Diabetic peripheral neuropathy (DPN) patients frequently feel persistent pain, which is described as painful diabetic peripheral neuropathy (PDPN), which begins in both feet and frequently spreads to the calves, fingers, and hands. PDPN not only causes pain, but also affects patients' sleep, emotions, mental state, and everyday activities, resulting in a low quality of life and a significant financial burden. The goal of this study was to monitor if there was a link between the prevalence, pattern, and related risk factors of diabetic peripheral neuropathy and hemoglobin A1C (HbA1c) levels. In this crosssectional study, 150 type-2 diabetic patients were screened for DPN with PDPN and their HbA1c level was measured in every three months. DPN, PDPN and non-painful DPN were confirmed in patients displaying both clinical manifestations of neuropathy and neurological abnormalities assessment. DPN was detected in 24% (n = 36), while PDPN was found at 15% (n = 23) of the total patients. The prevalence of PDPN is 63.88% (n = 23) and non-painful DPN is 36.11% (n = 13) of total DPN (n = 36). Out of total PDPN (n = 23), the prevalence of symmetrical pain is 65% (n = 15), asymmetrical 35% (n = 8), sensory 26% (n = 6), motor 13% (n = 3), mixed (sensorimotor) 61% (n = 14), lower limb involvement 48% (n = 11), upper limb13% (n = 3) and both limb 39% (n = 9). In comparison to patients without DPN, both PDPN and non-painful DPN, patients had greater HbA1c levels (p<0.05). Furthermore, advanced age and longer diabetes duration were considerable and significant (p<0.05) risk factors for DPN with PDPN and non-painful DPN respectively. Overall, the findings imply that elevated HbA1c levels are closely linked to DPN, PDPN and non-painful DPN in type-2 diabetic patients and that HbA1c might be used as a predictive marker for DPN with PDPN and non-painful DPN in the patients studied.
J. Bio-Sci. 29(2): 123-138, 2021 (December)
Cost-effectiveness and budget impact analysis for high dose quadrivalent influenza vaccine in the Italian elderly population
Authors: Rumi Filippo , Basile Michele , Cicchetti Americo
Published: August 2021

Introduction. Influenza is a widespread acute respiratory disease and represents a serious Public Health problem, both from the NHS and society perspectives. The High Dose quadrivalent influenza vaccine (QIV HD) is a flu vaccine containing 4 times the antigens of a Standard Dose vaccine, resulting in demonstrated superior protection in the population aged 65 years and over. Methods. The analysis has been conducted from the perspective of the NHS. The CEA focuses on the comparison between QIV HD and the QIV SD vaccine. The BIM aims to estimate the potential economic impact for the National Health Service (NHS) resulting from the use of QIV HD in clinical practice in subjects aged 65 or over, when considering its introduction in combination with currently used vaccines, QIV SD and adjuvanted TIV. Results. In a scenario which considers hospitalizations possibly related to influenza, so including cardio-respiratory events, a dominant cost-effectiveness profile emerges in the comparison with QIV SD. In terms of budget impact, overall savings obtained by comparing the two scenarios regarding hospitalizations are equal to 92,766,429 € over the three years’ time horizon considered in the analysis. Conclusions. Nowadays, also considering the state of emergency due to the spread of the SARS-CoV-2 virus, it is crucial to implement innovative health technologies that improve the efficiency and sustainability of the health system. Also, it is essential to protect the elderly population, helping to avoid overload and healthcare systems disruption due to the many COVID-19 hospitalizations.
Condutas em saúde mental na estratégia saúde da família: Revisão integrativa
Authors: Sousa Júnior Ribeiro de , Oliveira Jorgeana Tereza Martins de , Cruz Francisca Maria Pereira da , Neri George Ventura Alves , Lima Lorena Gomes de Abreu , Silva Francisco Edson das Chagas , Macedo Alana Mara Almeida , Silva Jordeilson Luis Araújo , Silva Michelle Leane Santana
Published: August 2021

A ESF tem como missão contribuir para a mudança do modelo assistencial dos sujeitos em sofrimento psíquico, estabelecendo mais um espaço estratégico e adequado para trabalhar com a saúde mental. O objetivo desse estudo é pontuar as condutas da equipe de estratégia de saúde da família na assistência em saúde mental. Trata-se de uma revisão integrativa, a qual realizou uma ampla pesquisa na literatura procurando identificar e extrair informações da literatura nacional e internacional por meio das seguintes bases de dados: Medline, LILACS, BDENF, IBECS, CUMED, BBO- odontologia, Secretaria Estadual de Saúde de São Paulo e Coleciona SUS-BR, Index Psicologia-Periódicos técnicos científicos, CVSP, Secretaria Municipal de Saúde de São Paulo, Mosaico- saúde integrativa e Repositório RHS dos anos de 2010 a 2020. Foi encontrado um quantitativo de 345 disponibilizados na integra que após aplicação dos critérios de inclusão e exclusão restaram 11 para análise. Os artigos indicam que os profissionais do PSF reconhecem suas dificuldades teóricas e práticas em lidar com portadores de transtornos mentais. Uma tentativa inicial para reorganização da assistência em saúde mental na ESF seria a incorporação dos princípios do próprio programa às ações dirigidas nesse sentido. Além, ações educativas em saúde e grupos de discursões sobre cada paciente com transtorno mental. Espera-se que os resultados possam nortear estratégias de educação permanente em saúde que viabilizem o empoderamento dos trabalhadores no processo de cuidado, com valorização de sua dimensão subjetiva para reconfiguração do modelo de assistência.