bluuebunny/crossref_metadata_2025 huggingface dataset:
Proteomics Analysis of CA1 Region of the Hippocampus in Pre-, Progression and Pathological Stages in a Mouse Model of the Alzheimer’s Disease
Authors: Gurel Busra , Cansev Mehmet , Koc Cansu , Ocalan Busra , Cakir Aysen , Aydin Sami , Kahveci Nevzat , Ulus Ismail Hakki , Sahin Betul , Basar Merve Karayel , Baykal Ahmet Tarik
Published: July 2019

Background:

CA1 subregion of the hippocampal formation is one of the primarily affected
structures in AD, yet not much is known about proteome alterations in the extracellular milieu of this
region.

Objective:

In this study, we aimed to identify the protein expression alterations throughout the
pre-pathological, progression and pathological stages of AD mouse model.

Method:

The CA1 region perfusates were collected by in-vivo intracerebral push-pull perfusion from
transgenic 5XFAD mice and their non-transgenic littermates at 3, 6 and 12 wereβmonths of age. Morris
water maze test and immunohistochemistry staining of A performed to determine the stages of the disease
in this mouse model. The protein expression differences were analyzed by label-free shotgun proteomics
analysis.

Results:

A total of 251, 213 and 238 proteins were identified in samples obtained from CA1 regions of
mice at 3, 6 and 12 months of age, respectively. Of these, 68, 41 and 33 proteins showed statistical significance.
Pathway analysis based on the unique and common proteins within the groups revealed that
several pathways are dysregulated during different stages of AD. The alterations in glucose and lipid
metabolisms respectively in pre-pathologic and progression stages of the disease, lead to imbalances in
ROS production via diminished SOD level and impairment of neuronal integrity.

Conclusion:

We conclude that CA1 region-specific proteomic analysis of hippocampal degeneration
may be useful in identifying the earliest as well as progressional changes that are associated with Alzheimer’s
disease.
Biomechanical Forces and Atherosclerosis: From Mechanism to Diagnosis and Treatment
Authors: Genkel Vadim V. , Kuznetcova Alla S. , Shaposhnik Igor I.
Published: July 2019

:

The article provides an overview of current views on the role of biomechanical forces in
the pathogenesis of atherosclerosis. The importance of biomechanical forces in maintaining vascular
homeostasis is considered. We provide descriptions of mechanosensing and mechanotransduction.
The roles of wall shear stress and circumferential wall stress in the initiation, progression and
destabilization of atherosclerotic plaque are described. The data on the possibilities of assessing
biomechanical factors in clinical practice and the clinical significance of this approach are presented.
The article concludes with a discussion on current therapeutic approaches based on the
modulation of biomechanical forces.
Halo effect moderating: impact of professional skepticism on auditor performance
Authors: Septian Ihwan , Astika Ida Bagus Putra
Published: July 2019

The Public Accountant profession has a role in supporting a healthy and efficient economy and increasing transparency and quality of financial information. Good auditor performance is needed to provide transparent and quality financial information to all interested parties. Good auditor performance can be carried out if an auditor is able to maintain professional skepticism and other factors in carrying out audit assignments and is not affected by factors that can reduce professional skepticism, one of which is the occurrence of a halo effect in assessing the client's overall business risk. The research was conducted to provide empirical of the halo effect in moderating professional skepticism on the auditor performance at Public Accounting Firm (KAP) in Bali Province. The population in this research were all KAP auditors in Bali Province which registered in the Directory and published by Indonesian Institute of Certified Public Accountants (IAPI) in 2019. The sampling technique used purposive sampling with the auditor criteria who are actively working in KAP in Bali Province and has audit experience of at least one year and ever been a team leader in the audit at least once.
Application of Ultra-high Pressure Processing Technology
Authors: Chen Jun , Pei Yu , Xu Shi Yan
Published: July 2019

High pressure processing is an innovation for the traditional food processing and preservation method. Since the method of ultra-high pressure processing (HPP) exerts a very little influence on the covalent bond of food, its influence on the nutrition, taste, and texture of food is minimized. However, HPP food is perishable in long distance transportation and sales process. Since food freshness directly affects the final demand in market, how to use the appropriate strategy to manage commodity stocks effectively during the long time and distance in food transportation and match the supply and demand of HPP food to improve the competitiveness of companies are the challenges faced by HPP food companies in upstream and downstream supply chain. This paper describes of the different features of HPP foods compared to that of traditional processed foods, and analyzes the collaboration of HPP foods supply chain members.
Looking for asymmetries over the Mexican business cycle
Authors: Mejía Reyes Pablo , Díaz Carreño Miguel Ángel
Published: July 2019

In the context of the dominance of the Keynesian paradigm and the use of economic policies to stabilise economic fluctuations, the world economy experienced decades of sustained growth. Nonetheless, the mid-1970s witnessed a severe crisis and a deep recession that called the attention of researchers to revisit the analysis of the nature of business cycles (BC). Ever since, numerous theories have been put forward to investigate their causes, transmission mechanisms and effects. in turn, on the emperical side, different methodologies have been introduced to analyse the main features of business cycles, but soon two of them became the most popular in the literature. The first one is called growth cycles, an approach linked to the real BC theory proposed by Lucas (1977) and to the empirical methodology by Kydland and Prescott (1990).
Costos unitarios laborales verticalmente integrados por rama en México y Estados Unidos, 1970-2000
Authors: Ruiz Nápoles Pablo
Published: July 2019

El propósito específico de este estudio ha sido desarrollar y aplicar una metodología para medir los costos unitarios de trabajo relativos en el caso particular de dos países que son vecinos y socios comerciales, México y los Estados Unidos de América, para el periodo 1970-2000. El trabajo se divide en seis secciones. Después de esta introducción, en la segunda sección se presentan algunas consideraciones teóricas relacionadas con los costos laborales, los tipos de cambio reales, la competitividad y el comercio internacional. En la tercera sección se desarrolla la metodología que consiste en un modelo basado en el análisis de insumo-producto, diseñado para el cálculo de costos unitarios de trabajo por sector de producción. La cuarta sección está dedicada a la aplicación del modelo para el caso de México y Estados Unidos, de forma que se estiman los costos unitarios laborales relativos entre los dos países en el periodo 1970-2000. En la quinta sección se presentan y analizan los resultados del modelo como factores determinantes de las ventajas comparativas por rama en México. En esta sección se incluye un análisis del patrón de comercio. En la última sección se obtienen algunas conclusiones acerca de la naturaleza de las ventajas comparativas reveladas en México y de la capacidad predictiva del teorema Heckscher-Ohlin.
Las causas de la crisis de deuda en Europa y el papel de la integración regional
Authors: Panico Carlo
Published: July 2019

Durante 2010 la deuda gubernamental de Grecia, España, Portugal, Irlanda e Italia ha sufrido ataques especulativos, los cuales han causado intensas dificultades financieras, un pronunciado decremento en la tasa de crecimiento, mayor desempleo, inestabilidad económica y social, cambios en políticas económicas y sociales que no son deseados por la mayoría de la población y dramáticos conflictos sociales. En julio y agosto la tasa de interés a diez años de los bonos del gobierno de Grecia, el país más afectado, se movió alrededor de 10.3%, un nivel considerado insostenible ¿porqué sucedió esto? ¿Pudo haberse evitado? ¿Las autoridades están operando efectivamente para resolver el problema y evitar futuras dificultades?
Microfinanzas y la tenencia de activos no financieros en México
Authors: Cotler Pablo , Rodríguez-Oreggia Eduardo
Published: July 2019

A principios de la década de los noventa se desató una vorágine de trabajos académicos que tenían por objeto medir la contribución del crédito bancario al crecimiento económico.1 A pesar de las múltiples discusiones que se han dado en torno a las metodologías ahí utilizadas, a estas alturas hay un relativo consenso en la literatura económica respecto a que un mayor desarrollo financiero contribuye a un mayor crecimiento económico.
Inestabilidad financiera y política monetaria en México, 1990-2008
Authors: Avendaño Vargas Blanca Lilia , Vázquez Muñoz Juan Alberto
Published: July 2019

Las reformas estructurales que experimentó la economía mexicana a partir de la mitad de los años ochenta, hicieron de la liberalización comercial (LC), la liberalización financiera (LF), la política monetaria y las exportaciones las variables determinantes del crecimiento económico.
MACROECONOMIC POLICY, GROWTH AND INCOME DISTRIBUTION IN THE BRAZILIAN ECONOMY IN THE 2000s
Authors: Serrano Franklin , Summa Ricardo
Published: July 2019

The purpose of this paper is to show that the interaction between large changes in the external conditions facing the Brazilian economy since 2003 and smaller changes in the orientation of domestic economic policy after 2005 explain the improved control of inflation, the recovery of more satisfactory rates of economic growth and the stronger improvement in income distribution and poverty reduction in the second half of the decade. The change in the orientation of economic policy also explains the relatively moderate contraction and strong recovery of the economy after the world crisis hit Brazil in late 2008.
Peran Kepercayaan Memediasi Hubungan Promosi Politik dan Citra Kandidat Terhadap Keputusan Pemilihan Kepala Desa
Authors: Liantifa Melifia
Published: July 2019

The purpose of the research was to investigate the intervening effect of trust on the relationship between political promotian and candidate image and selection decision of The Rural Districts Major in Siulak Kecil Hilir. The research of sample was all constituents who used voting rights in the Period of 2016 which accounted for 263 constituents using simple random sampling method. Data was colected through questionnaire with Likert’s scale which analysis using deskriptive qualitative and quantitative as test of validity and reliability, coefisien of determination, hypothesis testing performs hierarchical regression analysis by processing the data using SPSS 19.0 for windows. The result of analysis found that: a) political promotian and candidate image significantly influeced constituens trust and  selection decision of The Rural Districts Major in Siulak Kecil Hilir. b) Constituens trust significantly influeced selection decision. While, c) Constituens trust was  found as intervening variable between political promotian and candidate image and selection decision of The Rural Districts Major in Siulak Kecil Hilir. The research findings provide practical contribution especially for candidates The Rural Districts Major to future  to consider constituents trust and enhancing both political promotion and candidate image.

 

Penelitian ini bertujuan untuk mengetahui pengaruh kepercayaan sebagai variabel pemediasi promosi politik dan citra kandidat terhadap keputusan pemilihan Kepala Desa Siulak kecil Hilir Tahun 2016. Sampel dalam penelitian ini adalah pemilih yang menggunakan hak pilihnya yang berjumlah 263 pemilih dengan metode pengambilan sampel menggunakan cara acak sederhana. Data dikumpulkan melalui kuesioner dengan skala Likert yang dianalisis dengan metode deskriptif  kualitatif dan deskriptif kuantitatif seperti uji validitas dan reliabilitas, koefisien determinasi, uji hipotesis dengan analisis regresi bertingkat dengan pengolahan data menggunakan SPSS 19.0 for windows. Hasil penelitian menemukan bahwa: a) Promosi politik dan citra kandidat berpengaruh signifikan terhadap kepercayaan dan keputusan pemilihan Kepala Desa Siulak Kecil Hilir. b) Kepercayaan berpengaruh signifikan terhadap keputusan pemilihan Kepala Desa. Disamping itu, c) Kepercayaan berperan sebagai variabel pemediasi antara promosi politik dan citra kandidat terhadap keputusan pemilihan Kepala Desa Siulak Kecil Hilir, Kerinci. Hasil penelitian ini memberikan rekomendasi praktis khususnya kepada para kandidat Kepala Desa di masa yang akan datang, meningkatkan kepercayaan melalui peningkatan promosi politik dan citra kandidat.
Analisis Naratif Berita dalam Majalah Tempo Edisi 20-26 Mei 2019 sebagai Alternatif Bahan Ajar Mata Kuliah Bahasa Indonesia
Authors: Musdolifah Ari
Published: July 2019

Abstrak

Penelitian ini dilatarbelakangi kurangnya pemahaman mahasiswa Program Studi Pendidikan Bahasa dan Sastra Indonesia semester 1 Universitas Balikpapan. tentang keterampilan menulis, khususnya pada materi menulis paragraf dan menulis artikel ilmiah pada Mata Kuliah Bahasa Indonesia. Tujuan penelitian ini adalah mendeskripsikan analisis naratif berita dalam Majalah Tempo dan implementasi struktur narasi pada Mata Kuliah Bahasa Indonesia. Penelitian ini menggunakan metode deskriptif dengan jenis penelitian kualitatif. Teknik analisis data dalam penelitian ini menggunakan teknik analisis naratif oleh Tzevetan Todorov dengan struktur narasi yang dimodifikasi oleh Nick Lacey dan Gillespie.  Hasil penelitian ini menunjukkan bahwa struktur narasi yang terdapat pada berita “Detik-Detik yang Menentukan”, “Satu Pemilu Dua Sikap”, “Cacar Monyet di Negeri Singa”, “Siberut Terancam Hutan Industri”, “Bukti Campur Tangan Menteri Lukman”, “Jerat Makar Pengancam Presiden”, terdapat lima berita yang menyajikan persitiwa secara kronologis dan satu berita yang tidak kronologis. Berdasarkan hasil implementasi struktur narasi pada Majalah Tempo edisi 20-26 Mei 2019, diketahui hasil tulisan paragraf narasi yang memiliki urutan peristiwa secara kronologis adalah 88,2% dan tulisan artikel ilmiah yang memenuhi syarat sesuai dengan indikator sistem penulisan artikel ilmiah adalah 82,3%.

Kata kunci: Struktur narasi, berita, majalah Tempo

 

Abstract

This research is motivated by a lack of understanding of students in the 1st semester of Indonesian Language and Literature Education Study Program at University of Balikpapan. about writing skills, especially in writing paragraphs and writing scientific articles on Indonesian Language Courses. This research uses descriptive method with qualitative research to describe the structure of news narratives in Tempo Magazine. Data analysis techniques in this study used narrative analysis techniques by Tzevetan Todorov with a narrative structure modified by Nick Lacey and Gillespie. The results of this study indicate that the structure of the narrative contained in the news “Determining Seconds”, “One Election Two Attitudes”, “Monkey Smallpox in the Lion Country”, “Siberut Threatened by Industrial Forests”, “Interference Proof of Minister Lukman”, “Pitfalls of the President's Threat”, there are five news items that present chronologically and two news that is not chronological. Based on the implementation of the narrative structure at the magazine Tempo 20-26 edition 2019 may show that paragraph narrative writing having a sequence of events in chronological order is 88,2 % and in writing scholarly article qualified in accordance with an indicator of a writing system scientific article is as much as 82,3 %.

Keywords: Narrative structure, news, Tempo magazine.
La revista Hospital a Domicilio en Latindex
Authors: Sanz-Lorente María , Bojo Canales Cristina
Published: July 2019

El presente artículo presenta el sistema de información Latindex como producto de colaboración en el ámbito iberoamericano, así como su cobertura e impacto. Se describe el Catalogo 2.0 como servicio de información cualitativa que está basado en una lista de características diseñadas por un grupo de especialistas para Latindex que trabajó en su confección entre 1999 y 2001. Esta lista permite apreciar el grado de calidad editorial de cada revista, los criterios que cumple y los que no.Al tiempo, se destaca la participación española, no sólo por su cantidad de producción, sino por el nivel académico de la misma, destacando especialmente las revistas de Humanidades y Ciencias Sociales. De todos modos, y de forma global, se puede observar que si bien aún en minoría en cuanto al número de publicaciones, las revistas científicas españolas del área de las Ciencias de la Salud mostraban un elevado cumplimiento de los parámetros incluidos en la metodología Latindex.Por último se deja constancia de la aceptación de la revista Hospital a Domicilio, enfatizando en el alto nivel de cumplimiento de las características Latindex.
Music Hall: Regulations and behaviour in a British cultural institution
Authors: Scott Derek
Published: July 2019

The music hall in late nineteenth-century Britain offers an example of a
cultural institution in which legal measures, in-house regulations, and
unscripted codes of behaviour all come into play. At times, the performers
or audience were under coercion to act in a certain way, but at other times
constraints on behaviour were more indirect, because the music hall created
common understanding of what was acceptable or respectable. There is,
however, a further complication to consider: sometimes insider notions of
what is normative or appropriate come into conflict with outsider concerns
about music-hall behaviour. These various pressures are examined in the
context of rowdiness, drunkenness, obscenity, and prostitution, and
conflicts that result when internal institutional notions of what is
normative or appropriate come into conflict with external social anxieties.
Modeling of transport processes in the cigarette principle combustion furnace
Authors: Eric Aleksandar , Nemoda Stevan , Komatina Mirko , Repic Branislav , Dakic Dragoljub
Published: July 2019

This paper presents numerical and experimental investigations of complex and interrelated physical and chemical phenomena that occur during combustion of baled soybean residue in the furnace with the cigarette type of combustion. The result of comprehensive research is reactive flow model of biomass combustion inside furnace. Model is described by set of PDE which define momentum, heat and mass transfer processes in porous and fluid system. The main aim of developed CFD model is numerical simulation of combustion process inside the cigarette furnace. It is also used to provide deeper insight in complex processes occurring during biomass combustion. Verification of proposed numerical model was performed through comprehensive experimental tests on the experimental-industrial plant of 1.5 MW boiler for heating the greenhouses in the Agricultural Corporation in Belgrade. The tests included measurement of flow rate and air and flue gas temperature input and output values on the furnace that are taken as the boundary conditions of the developed model. Comparison of the experimental results shows satisfactory agreement with numerical results (the maximum relative deviation of calculation and measurement temperatures are 10-45%), therefore the developed mathematical model could be used to analyse the effects of structural and parametric (fuel composition, power rate, air excess etc.) changes of the facility, from the standpoint of energy efficiency and ecology.
PENGARUH E-LEARNING SCHOOLOGY TERHADAP HASIL BELAJAR PEMROGRAMAN WEB DAN PERANGKAT BERGERAK SISWA (Studi Kasus : Kelas XI RPL di SMK Negeri 1 Negara)
Authors: Sulistyawati Candra , Agustini Ketut , Pradnyana Gede Aditra
Published: July 2019

ABSTRAKTujuan penelitian ini untuk mengetahui (1) pengaruh e-learning schoology terhadap hasil belajar siswa mata pelajaran Pemrograman Web dan Perangkat Bergerak kelas XI RPL di SMK Negeri 1 Negara, (2) respon siswa setelah menggunakan e-learning schoology pada mata pelajaran Pemrograman Web dan Perangkat Bergerak kelas XI RPL di SMK Negeri 1 Negara. Jenis penelitian ini adalah eksperimen semu (quasi eksperimen) dengan desain Post Test Only Control Group Design. Populasi penelitian mencakup seluruh siswa kelas XI RPL di SMK Negeri 1 Negara Tahun Pelajaran 2018/2019. Sampel penelitian yang digunakan yaitu kelas XI RPL 1 sebagai kelompok kelas eksperimen dan kelas XI RPL 2 sebagai kelompok kelas kontrol dengan jumlah sampel 70 orang. Metode pengumpulan data yang digunakan yaitu metode tes dalam bentuk tes essay untuk mengetahui ranah kognitif dan metode angket atau kuesioner untuk mengetahui respon siswa. Data hasil belajar dianalisis melalui uji prasyarat yaitu meliputi uji normalitas dan uji homogenitas dengan hasil kedua kelompok berdistribusi normal dan homogen, dilanjutkan dengan uji hipotesis yang menggunakan uji t. Hasil penelitian diperoleh thitung 7,1916 yang lebih besar dari ttabel 1,9955 yang menyatakan bahwa (1) terdapat perbedaan hasil belajar yang lebih tinggi antara siswa yang belajar dengan menggunakan e-learning schoology dengan siswa yang belajar dengan menggunakan power point. Hal ini dapat dilihat dari rata-rata kelompok eksperimen adalah sebesar 32,72 dan rata-rata kelompok kontrol adalah 27,56. (2) respon siswa dari penggunaan e-learning schology pada mata pelajaran Pemrograman Web dan Perangkat Bergerak adalah sangat positif dilihat dari rata-rata skor hasil angket respon siswa yaitu 84,72. Kata kunci: E-learning, Hasil Belajar, Pemrograman Web dan Perangkat Bergerak, Schoology
Opiniões de estudantes de um curso de graduação em Enfermagem sobre a doença mental
Authors: Mendes Alini De Oliveira Souza , Pereira Carolina Munhoz , Scattolin Fátima Ayres de Araújo
Published: July 2019

Introdução: Mesmo com as mudanças trazidas pela Reforma Psiquiátrica, ainda persistem conceitos e visões estereotipadas e negativas em relação ao doente mental, o que dificulta uma assistência integral e qualificada. Objetivo: Avaliar a opinião de estudantes ingressantes e formandos de um curso de graduação em Enfermagem de uma instituição de ensino superior do interior do estado de São Paulo diante da doença mental. Método: Trata-se de um estudo exploratório de natureza quantitativa. Para coleta de dados foram utilizados: Instrumento de caracterização dos sujeitos e a Escala de Opiniões sobre a Doença Mental (ODM). Foram realizadas análises estatísticas descritiva, de comparação e correlação. O nível de significância utilizado foi de p<0.05. Resultados: Participaram deste estudo 38 estudantes: 21 ingressantes e 17 formandos. Houve predomínio de mulheres (97,37%) e a média de idade foi 24,42 (±6,64) anos. Em relação aos fatores da ODM, as médias dos escores não mostraram grande variação. Alunos ingressantes apresentaram escores mais altos em todos os fatores, porém essa diferença foi significante (p=0,04) apenas no fator visão minoritária. Católicos apresentaram escores maiores no fator Ideologia da higiene mental (p=0,02). Alunos trabalhadores apresentaram menores escores nos fatores Benevolência e Ideologia da higiene mental e essas diferenças foram significantes (p=0,01 e p=0,02 respectivamente). Conclusão: Os resultados deste estudo mostraram mais semelhanças do que diferenças em relação à percepção da doença mental nos dois grupos. Demonstraram também tendência para atitudes positivas, contrariando a ideia de reclusão e fortalecendo o entendimento de que o doente mental deve estar inserido na sociedade.
Percepção das mulheres no climatério em relação à sexualidade, à prevenção de doenças sexualmente transmissíveis e à qualidade da assistência pelos profissionais da saúde
Authors: Perone Giulia Aneas , Ferraz Taisa Maria Monteiro , Pinheiro Vitória Alcântara , Jeneral Ruth Bernarda Riveros
Published: July 2019

Introdução: A fase climatérica, além de apresentar diversas alterações fisiológicas decorrentes do declínio das concentrações hormonais que interferem na qualidade de vida, sexualidade e autopercepção, ainda carrega os preconceitos e tabus criados pela sociedade. Objetivo: Identificar a percepção das mulheres na fase do climatério em relação aos sintomas apresentados, à sua sexualidade, ao uso de preservativo para prevenção de doenças sexualmente transmissíveis e à qualidade da assistência prestada pelos profissionais da saúde nessa fase. Metodologia: Trata-se de uma pesquisa descritiva com análise qualitativa, que incluiu 15 mulheres na faixa etária de 40 a 65 anos em condições de comunicação. Para a coleta de dados foi realizada uma entrevista gravada em áudio com a questão norteadora: “Como você se sente nessa fase da vida em relação à sua sexualidade, às doenças sexualmente transmissíveis e à assistência do profissional da saúde?”. Para a análise dos dados foi utilizada a técnica do discurso do sujeito coletivo, que visa dar luz ao conjunto de individualidades semânticas componentes do imaginário social. Resultados: Das 15 entrevistas, foi possível identificar 11 ideias centrais e 11 discursos. Mulheres climatéricas na faixa de 54 a 63 anos; 98% usam preservativos; 94% têm vida sexual ativa e companheiros há mais de 10 anos. Considerações finais: Percebeu-se que a parte do objetivo que contemplava a qualidade da assistência prestada pelos profissionais de saúde foi inconclusiva. Assim sendo, não obtivemos resultado final para esse tema, por ser entendido como um aspecto mais abrangente.
Antibacterial activity of selected snake venoms on pathogenic bacterial strains
Authors: Boda Francisc Andrei , Mare Anca , Szabó Zoltán István , Berta Lavinia , Curticapean Augustin , Dogaru Maria , Man Adrian
Published: July 2019

Snake venoms are aqueous solutions containing peptides and proteins with various biochemical, physiological, and pathophysiological effects. Several snake venom components are used as lead molecules in the development of new active substances for the treatment of cardiovascular diseases, clotting disorders, cancer or pain.

Antibacterial activity has also been attributed to snake venoms and proteins isolated from snake venoms. This study provides information regarding the antibacterial activity of venoms obtained from various snake species from the Elapidae and Viperidae families. Minimum inhibitory and bactericidal concentrations of snake venoms were determined for three Gram-positive (Enterococcus faecalis ATCC 29212, Staphylococcus aureus ATCC 29213, and Methicillin-resistant Staphylococcus aureus ATCC 43300) and three Gram-negative (Escherichia coli ATCC 25922, Klebsiella pneumoniae ATCC 13883, and Pseudomonas aeruginosa ATCC 27853) pathogenic bacteria. The observed effects were correlated with the protein content of each venom, determined using SDS-PAGE analysis and comparison with data available in the literature. Our findings represent a starting point for the selection of snake venoms containing components with potential use as lead molecules in the development of new antibacterial agents, targeting multidrug resistant bacterial strains.
Magnesium isoglycyrrhizinate protects against concanavalin A-induced immunological liver injury in a mouse model
Authors: Jiang Zhengyan , Zheng Liang
Published: July 2019

Background: To evaluate the protective effects of magnesium isoglycyrrhizinate on a mouse model of concanavalin A (ConA)-induced immunological liver injury. Materials and Methods: Forty-eight mice were randomly divided into a normal control group, a model group, three dose groups of magnesium isoglycyrrhizinate (12.5, 25, 50 mg/kg) and a dexamethasone group (2.5 mg/kg). Magnesium isoglycyrrhizinate was intraperitoneally injected for 5 consecutive days, and the model of immunological liver injury was established on the fifth day after caudal vein injection of ConA (20 mg/kg). Blood was collected to detect the activities of alanine transaminase (ALT) and aspartate transaminase (AST) as well as the levels of tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ). The levels of neopterin (NP) and malondialdehyde (MDA) and the activities of myeloperoxidase (MPO) and superoxide dismutase (SOD) in liver tissues were measured, and histopathological changes were observed. Results: The serum levels of ALT and AST in the model group increased. Hepatic lobules had necrotic foci and inflammatory cell infiltration. The plasma levels of TNF-α and IFN-γ increased. In liver tissues, the levels of NP, MDA and MPO rose, but that of SOD decreased. Magnesium isoglycyrrhizinate significantly attenuated the activities of ALT and AST (P<0.05). Histopathological staining showed that inflammation of the liver was relieved significantly. Magnesium isoglycyrrhizinate also decreased the levels of NP, MDA and MPO in liver tissues (P<0.05), raised that of SOD and reduced the plasma levels of TNF-α and IFN-γ (P<0.05). Conclusion: Magnesium isoglycyrrhizinate protected against ConA-induced immunological liver injury in mice, probably through immune regulation and antioxidation.
Effects of obstruent voicing on vowel F0: Implications for laryngeal realism
Authors: Kirby James , Ladd D. Robert
Published: July 2019

It is sometimes argued that languages with two-way laryngeal contrasts can be classified according to whether one series is realized canonically with voicing lead or the other with voicing lag. In languages of the first type, such as French, the phonologically relevant feature is argued to be [voice], while in languages of the second type, such as German, the relevant feature is argued to be [spread glottis]. A crucial assumption of this position is that the presence of certain contextually stable phonetic cues, namely voicing lead or lag, can be used to diagnose the which feature is phono-logically active.

In this paper, we present data on obstruent-intrinsic F0 perturbations (CF0) in two [voice] languages, French and Italian. Voiceless obstruents in both languages are found to raise F0, while F0 following (pre)voiced obstruents patterns together with sonorants, similar to the voiceless unaspirated stops of [spread glottis] languages like German and English. The contextual stability of this cue implies that an active de-voicing gesture is common to languages of both the [voice] and [spread glottis] types, and undermines the idea that a strict binary dichotomy between true voicing and aspirating languages can be reliably inferred based on properties of the surface phonetics.
PERBEDAAN PROBLEM BASED LEARNING DAN DISCOVERY LEARNING TERHADAP PEMAHAMAN SISTEM REPRODUKSI TUMBUHAN DAN HEWAN
Authors: Chodijah Ratu Siti , Rais Muh , Hadi Nestiyanto
Published: July 2019

Abstrak: Penelitian ini bertujuan untuk mengetahui perbedaan pembelajaran PBL dan Discovery Learning terhadap pemahaman siswa pada sistem reproduksi tumbuhan dan hewan. Penelitian dilakukan di SMP.IT Al Fariida dan SMP.IT Luqman Al Hakim Desa Jampang Kecamatan Kemang Kabupaten Bogor. Dalam penelitian ini digunakan metode deskriptif kuantitatif dengan pendekatan studi eksperimendua variabel hasil tes (Y1 dan Y2) dari pemahaman siswa yang belajar dengan model PBL (X1) dan hasil tes dari pemahaman siswa yang belajar dengan model Discovery Learning (X2). Data kedua variabel hasil tes dideskripsikan melalui frekuensi kelas interval data dan nilai-nilai terpusat, yaitu modus (Mo), median (Md), mean (Me) dan nilai simpangan baku (S). Perbedaan pembelajaran PBL dan Discovery Learning diketahui melalui Uji t-perbedaan. Ukuran sampel sebanyak 30 siswa kelas IX SMP.IT Al Fariida dan 30 siswa kelas IX SMP.IT Luqman Al Hakim. Instrumen tes dalam bentuk soal pilihan ganda sebanyak 30 butir soal. Berdasarkan hasil analisis data diperoleh bahwa terdapat perbedaan model pembelajaran PBL dan discovery learning terhadap pemahaman siswa pada sistem reproduksi tumbuhan dan hewan. Dapat disimpulkan bahwa PBL lebih efektif dibandingkan Discovery Learning dengan indikasi meningkatnya motivasi, pengalaman dan pengetahuan serta kemampuan siswa dalam memecahkan permasalahan.Kata kunci : Problem Based Learning (PBL), Discovery Learning, Pemahaman siswa, Instrumen tes.
ANALISIS DAMPAK PERUBAHAN IKLIM TERHADAP TINGKAT KESEJAHTERAAN NELAYAN DI DESA SUNGAI KAKAP KABUPATEN KUBU RAYA
Authors: Kartini, Erni Yuniarti Tezario Chandra Putra
Published: July 2019

ABSTRAK-- Pemanasan global berdampak pada perubahan iklim dan berimplikasi terhadap sektor kelautan.Dampak yang paling nyata adalah berubahnya pola presipitasi serta arah dan kecepatan anginsehingga berdampak pula terhadap hasil tangkapan nelayan. Penelitian ini bertujuan untuk: (1)menganalisis dampak yang ditimbulkan akibat perubahan iklim terhadap sektor perikanan diDesa Sungai Kakap; (2) mengestimasi besarnya tingkat kesejahteraan nelayan di Desa SungaiKakap sebagai akibat terjadinya perubahan iklim; (3) menganalisis strategi adaptasi yangdilakukan oleh nelayan di Desa Sungai Kakap dalam menghadapi perubahan iklim. Metoda yangdigunakan dalam penelitian ini adalah membandingkan tren hasil tangkapan nelayan dengankondisi iklim yang terjadi. Untuk mengestimasi besarnya tingkat kesejahteraan nelayan dhitungmenggunakan Nilai Tukar Nelayan, sementara analisis adaptasi nelayan menggunakan metodeanalisis deskriptif. Hasil penelitian menunjukkan bahwa faktor yang memiliki dampak paling besarterhadap turunnya hasil tangkapan nelayan adalah curah hujan, karena lingkup penelitian inidibatasi pada daerah pesisir sehingga arah dan kecepatan angin serta tinggi gelombang tidakmemberi dampak terhadap nelayan dalam melaut. Curah hujan yang tinggi berdampak terhadapsalinitas air laut sehingga menyebabkan turunnya hasil tangkapan nelayan. Curah hujan rata-ratadalam kurun waktu 2008-2012 di Sungai Kakap adalah 2.662,4 mm dengan penurunan hasiltangkapan dari tahun 2009-2012 sebesar 3.316,7 ton. Nilai Tukar Nelayan (NTN) di Desa SungaiKakap Tahun 2012 sebesar 0,84 yang mengindikasikan keluarga nelayan di Desa Sungai Kakapmempunyai daya beli yang rendah dalam memenuhi kebutuhan keluarganya dan mengalamidefisit anggaran rumah tangga. Pola adaptasi yang dilakukan nelayan dalam menghadapiperubahan iklim tersebut adalah dengan menerapkan pola pemasukan ganda, yaitu denganmencari tambahan pemasukan melalui usaha non perikanan.Kata Kunci: perubahan iklim, nelayan, kesejahteraan
STUDI PENGOLAHAN AIR LIMBAH UNTUK KAWASAN PEMUKIMAN KABUPATEN KUBU RAYA
Authors: Yanuar Lorensius
Published: July 2019

Angka pertumbuhan penduduk berbanding lurus dengan peningkatan jumlah air limbah. Air limbah yang dihasilkan terutama yang mengandung ekskreta manusia dapat mengandung patogen yang berbahaya, oleh karena itu harus dikelola dan diolah dengan baik. Permasalahan yang terjadi pada wilayah permukiman di Kabupaten Kubu Raya, khususnya Kecamatan Sungai Raya adalah belum adanya sistem pengolahan limbah untuk limbah non toilet dan sistem pengolahan limbah setempat yang dimiliki umumnya belum dapat mengolah limbah toilet dengan maksimal. Studi yang ini dilakukan untuk memberikan rekomendasi sistem dan teknologi dalam pembangunan pengolahan air limbah untuk kawasan permukiman di daerah Kabupaten Kubu Raya. Studi ini dilakukan dengan cara menganalisa jumlah penduduk, volume air limbah total, dan kepadatan penduduk wilayah studi sebagai acuan dalam pembagian zonasi pengolahan air limbah, dimana zonasi ini yang akan menentukan teknologi pengolahan air limbah yang akan direkomendasikan untuk wilayah permukiman Kabupaten Kubu Raya. Di samping aspek teknis, juga dilakukan analisa mengenai aspek-aspek yang mempengaruhi dalam pengolahan air limbah. Pengolahan proyeksi jumlah penduduk, volume total air limbah, dan kepadatan penduduk menggunakan metode geometrik. Studi literatur dilakukan guna menganalisa aspek-aspek yang berpengaruh dalam pengolahan air limbah serta teknologi pengolahan air limbah untuk daerah spesifik. Dari hasil studi diperoleh bahwa Desa Sungai Raya dan Desa Limbung memiliki kepadatan yang cukup tinggi pada tahun 2032, sehingga teknologi pengolahan air limbah yang direkomendasikan adalah teknologi pengolahan komunal seperti MCK+ dan tangki septik komunal, sedangkan untuk Desa Teluk Kapuas, Arang Limbung, Kapur, dan Kuala Dua direkomendasikan teknologi pengolahan air limbah individual seperti tangki septik pribadi dan cubluk. Aspek-aspek non teknis yang mempengaruhi pengolahan air limbah adalah aspek demografi, ekonomi, sosial, geografis, serta kesehatan.
PENGGUNAAN TAWAS CAIR RECOVERY DARI LIMBAH PADAT LUMPUR PDAM KOTA PONTIANAK SEBAGAI KOAGULAN UNTUK PENGOLAHAN AIR BERSIH
Authors: MOERDIYANTI MEITY
Published: July 2019

ABSTRAK Limbah padat lumpur (LPL) PDAM dari proses koagulasi yang belum diolah atau dimanfaatkan hingga saat ini langsung dibuang ke Sungai Kapuas dan berpotensi mencemari air sungai. Studi terhadap pemanfaatan kembali aluminium pada LPL PDAM Kota Pontianak sebagai koagulan dilakukan untuk mengolah limbah sehingga dapat digunakan kembali dalam bentuk tawas cair, menentukan kondisi terbaik dan dapat menentukan biaya yang diperlukan untuk recovery dan aplikasinya. Recovery aluminium meliputi pengeringan dan kalsinasi lumpur, pengambilan kembali aluminium dengan metode asidifikasi menggunakan H2SO4 konsentrasi 10 M. Berat kering LPL PDAM yang digunakan sebesar 2 gram, kecepatan aduk 40 rpm selama 120 menit dan pengendapan selama 60 menit. Konsentrasi aluminium yang didapatkan dari tawas cair recovery sebesar 646, 13 ppm atau setara dengan 161,53 mg. Tawas cair recovery diaplikasikan pada proses koagulasi-flokulasi terhadap air baku untuk melihat efektifitas kerja tawas cair. Kondisi terbaik untuk tawas cair yaitu pada dosis 12 mg, kecepatan aduk cepat 160 rpm dan kecepatan aduk lambat 20 rpm dengan persen penyisihan kekeruhan sebesar 99,26%. Biaya yang diperlukan untuk proses recovery dan aplikasi pada tawas cair sebesar Rp 1.188/L. Kata kunci: recovery, tawas cair, koagulasi
EVALUASI TEKNIK OPERASIONAL PERSAMPAHAN KECAMATAN SAMBAS
Authors: Saugi Agung Ananda , Jati Dian Rahayu , Fitria Laili
Published: July 2019

ABSTRAKPermasalahan sampah timbul karena tidak seimbangnya produksi sampah dengan pengelolaannya. Menurut data dari Dinas Kependudukan dan Pencatatan Sipil, Kecamatan Sambas memiliki 56.787 warga pada tahun 2015. Setiap hari warga Kecamatan Sambas menghasilkan sampah sekitar 156,164 m3/ hari dan hanya 45% warga yang terlayani dengan asumsi satu orang menghasilkan 2,75 liter sampah perhari. Kinerja dari sistem pengelolaan sampah pada suatu kawasan atau wilayah akan menentukan kondisi lingkungan pada wilayah tersebut. Pengelolaan sampah di Kecamatan Sambas merupakan suatu permasalahan yang menjadi prioritas untuk diselesaikan. Peningkatan volume sampah yang dihasilkan dari berbagai aktivitas masyarakat membutuhkan penanganan dengan teknik operasional pengelolaan sampah perkotaan agar sampah – sampah yang dihasilkan oleh aktivitas masyarakat tidak menimbulkan berbagai masalah yang dapat mengganggu lingkungan masyarakat. Penelitian ini bertujuan untuk mengetahui umur zona timbunan TPA Sorat dan mengevaluasi teknik operasional persampahan di Kecamatan Sambas. Metode yang digunakan adalah pengamatan langsung di lapangan dan membandingkan antara kondisi teknik operasional di Kecamatan Sambas dengan SNI 19-2454-2002 tentang Tata Cara Teknik Operasional Pengelolaan Sampah Perkotaan. Analisis data dilakukan dengan melakukan perhitungan sesuai dengan SNI 3242-2008 tentang Pengelolaan Sampah di Permukiman. Hasil penelitian menunjukkan bahwa umur zona timbunan TPA Sorat diprediksi dapat mencapai hingga 9 tahun kedepan dengan akumulasi timbunan sampah mencapai 122.315 m3 dan zona timbunan yang dipersiapkan seluas 1,25 Ha, yaitu dari tahun 2016 sampai tahun 2025 serta teknik operasional persampahan pada aspek pengumpulan sampah dan pengangkutan sampah di Kecamatan Sambas masih belum seluruhnya menerapkan SNI 19-2454-2002.Kata Kunci : Kecamatan Sambas, TPA Sorat, Teknik Operasional
Pressing Induced Caking: A General Strategy to Scale-Span Molecular Self-Assembled Materials
Authors: Yan Yun , Jin Hongjun , Xie Mengqing , Wang Wenkai , Jiang Lingxiang , Chang Wenying , Sun Yue , Xu Limin , Zang Shihao , Huang Jianbing , Jiang Lei
Published: July 2019

We report that under mechanical pressure, caking of the precipitated molecular self-assemblies may lead to bulk supramolecular films. Massive fabrication of supramolecular films becomes possible using a simple household noodle machine. The film can be endowed diversified functions by depositing various functional ingredients via co-precipitation.
Heterogeneous Interactions Promote Crystallization and Spontaneous Resolution of Chiral Molecules
Authors: Carpenter John , Gruenwald Michael
Published: July 2019

Predicting the crystallization behavior of solutions of chiral molecules is a major challenge in the chemical sciences. In this paper, we use molecular dynamics computer simulations to study the crystallization of a family of coarse-grained models of chiral molecules with a broad range of molecular shapes and interactions. Our simulations reproduce the experimental crystallization behavior of real chiral molecules, including racemic and enantiopure crystals, as well as amorphous solids. Using efficient algorithms for the packing of shapes, we enumerate millions of low energy crystal structures for each model and analyze the thermodynamic landscape of polymorphs. In agreement with recent conjectures, our analysis shows that the ease of crystallization is largely determined by the number of competing polymorphs with low free energy. We find that this number, and hence crystallization outcomes, depend on molecular interactions in a simple way: Strongly heterogeneous interactions across molecules promote crystallization and favor the spontaneous resolution of racemic mixtures.
Atmospheric Oxidation of Piperazine Initiated by OH: A Theoretical Kinetics Investigation
Authors: Ren Zhonghua , da Silva Gabriel
Published: July 2019

Piperazine (Pz) mixed with other amines is a proposed carbon capture solvent, but there is concern about the impact of Pz on air quality, including the potential to produce toxic products. Here, the •OH initiated oxidation of Pz has been studied by ab initio modelling and RRKM / master equation kinetic simulations. The Pz + •OH reaction is found to proceed at around the capture rate, consistent with experiment, with abstraction predominantly from C—H sites. The subsequent reaction kinetics of carbon centred Pz radicals with O2 are also studied, so as to determine the first-generation oxidation products. We find that the Pz radical predominantly reacts with O2 to produce a cyclic imine product + HO2• under tropospheric conditions, with the stabilized peroxyl radical formed as a minor product. Subsequent reaction of the peroxyl radical with NO produces an alkoxyl radical that can react with O2 to yield a cyclic amide or undergo unimolecular ring opening followed by a second O2 addition / HO2• elimination step to produce CH2=NCH2CH2NHCHO.
Reaching a foreign audience
Authors: Ramière Nathalie
Published: July 2019

This paper examines some of the issues involved in the intercultural transfer of films. It focuses on the translation of culture-specific references and questions in particular the validity of the notions of foreignisation and domestication, brought to the fore of Translation Studies by Venuti (1995), as a conceptual framework traditionally used to discuss the strategies applied when translating cultural specifics. Drawing on the findings of a pilot study consisting of three French films dubbed and subtitled into English, this paper suggests a theoretical challenge by proposing a more pragmatic approach to the study of cultural transfer in audiovisual translation (AVT). More particularly, it will examine whether it is possible to observe any form of consistency in the strategies used for the translation of culturally-bound references and what this implies for the dialogic relationship between Self and Other, and the representation of alterity.KEYWORDS: Audiovisual translation, cultural transfer, culture-specific references, foreignisation, domestication
Impact of Transportation on Carbon Dioxide Emissions from Locally vs. Non-locally Sourced Food
Authors: Striebig Bradley , Smitts Eric , Morton Samuel
Published: July 2019

The concentration of carbon dioxide in the atmosphere continues to rise and the global food system is a significant contributor that often gets overlooked when it comes to solving the problem. In this study, emissions related to food transportation were studied to determine what impact getting local food instead of non-local food could make on the overall emissions of the food system. The dining service at University utilizes local food to varying extents when it is in season, and a life cycle assessment (LCA) was done on lettuce, tomatoes, strawberries, and chicken to compare the emissions associated with production of these foods. The transport-oriented GREET software was used for the LCA along with information from the sustainability coordinator at the university itself to get results. Given a lack of publicly available data regarding crop cultivation in certain areas of the U.S. some information had to be obtained from databases in Europe, but results suggest that produce coming from the west coast to the Virginia campus can have four to five times the emissions associated with production and produce from Florida can have roughly twice as many emissions associated with production. There is a relatively low number of LCAs done in America to compare this data to but it somewhat fits in with many European studies. Some LCAs do not factor in transportation processes but my results suggest that any American studies should factor in transportation since they can contribute greatly to the overall footprint of products. The current available software for LCAs lack consistency between programs, all having different strengths and weaknesses, and needs to be improved for quality results in the future.
El ciberriesgo, tensión para los saberes previos
Authors: Cano M. Jeimy J.
Published: July 2019

La acelerada transformación de las empresas y de la sociedad, acompañada del incremento de la densidad digital de los objetos físicos, establece un nuevo paradigma de comprensión social y económico, que debilita la visión mecanicista del mundo y privilegia una más relacional, en la que ya no son los elementos del sistema los que tienen el protagonismo, sino sus interacciones y conexiones conocidas (y emergentes).
Aplicación de los instrumentos internacionales en la ejecución de la pena
Authors: Martínez Ulloa Alicia
Published: July 2019

Este artículo ofrece una guía de los documentos básicos que conforman la aplicación de los instrumentos internacionales mínimos para la protección de los matices positivistas de los derechos humanos de las personas privadas dela libertad. También se presenta la intervención de juez de ejecución de penas en el punto relacionado con el Estado de Cosas inconstitucionales a partir de normas ius-fundamentales, legales y reglamentarias vigentes en Colombia