bluuebunny/crossref_metadata_2025 huggingface dataset:
Blood pressure management strategy in patients with acute ischemic stroke after mechanical thrombectomy (CHASE-MT): A prospective, multicenter, randomized controlled, open-label clinical trial protocol
Authors: Zhao Hanghang , Guo Xin , Shi Rui , Wei Dong , Li Yang , Yuan Xingyun , Zhu Hao , Li Weiwang , Chang Mingze , Li Jiang , Di Zhengli , Lei Hui , Zhang Ru , Yang Xi'ai , Zhang Huiping , Zhang Bei , Shi Yajun , Kang Zhoucheng , Yang Fang , Li Li
Published: January 2023

Background The efficient control of blood pressure (BP) after mechanical thrombectomy (MT) has not been determined, and there is a lack of multicenter, prospective, randomized controlled, open-label clinical studies on the precise management of BP in patients with acute ischemic stroke (AIS) after undergoing MT. This trial aims to determine whether potent antihypertensive therapy (90–110 mmHg) effectively reduces the incidence of symptomatic hemorrhagic transformation at 48 h after MT and the incidence of poor prognosis at 90 days after therapy in patients with AIS. Methodology/Design: This is a randomized, controlled, open-label, prospective, multicenter clinical trial. Patients with AIS treated with MT will be screened. A total of 324 adult patients with AIS (National Institutes of Health Stroke Scale (NIHSS) score, 6–19 points) will be recruited from 11 sites located in Shaanxi and Gansu pration system. The primary outcome measure is the proportion of patients in the trial group with a good prognosis (modified Rankin scale (mRS) score ≤ 2 points) at 90 days after treatment compared with the control group. The secondary outcome measures are the incidence of sICH due to reperfusion injury within 48 h after therapy, NIHSS score at 48 h after therapy, and mRS score at 14 days after therapy in both groups. Demographic characteristics, relevant medical history, characteristics of the occluded vessels, perioperative treatment, and monitoring results will be collected from all study subjects. The relationship between BP levels in AIS patients at 48 after successful recanalization and symptomatic hemorrhagic transformation and clinical prognosis will be explored. Discussion The CHASE-MT trial will be a large multicenter study that actively explores BP management strategies in patients with AIS undergoing MT. This trial has the potential to address the persistent BP elevation or high postoperative BP variability after successful recanalization in patients with AIS and to provide optimal BP levels. Trial registration: This trial was registered at ClinicalTrials.gov (Identifier: NCT05282290, Date of registration: June 13, 2022).
Atomically Dispersed d10 s-block Au Boosts Photocatalytic 1e- Water Oxidation for Self-Cleaning, Sanitation and Safe Drinkable Water­­
Authors: Teng Zhenyuan , Yang Hongbin , Zhang Qitao , Cai Wenan , Lu Ying Rui , Kato Kosaku , Zhang Zhenzong , ding jie , Sun Han , Liu Sixiao , Wang Chengyin , Chen Peng , Yamakata Akira , Su Chenliang , Liu Bin , Teruhisa Ohno
Published: January 2023

Providing affordable safe drinking water and universal sanitation poses a grand challenge especially after the global COVID-19 pandemic. In this work, we developed atomically dispersed Au on potassium-incorporated polymeric carbon nitride (AuKPCN) that could simultaneously boost photocatalytic generation of ·OH and H2O2with an apparent quantum efficiency over 90% at 400–420 nm. The introduction of potassium into the poly(heptazine imide) matrix formed strong K-N bonds, preventing Au from forming strong interactions with N. Instead, Au formed a bond with C, only having weak interactions with N on KPCN, which rendered Au with an oxidation number close to 0. The results ofin-situvibrational spectroscopy, isotopic experiments, transient absorption spectroscopy and time-dependent density functional theory (TDDFT) simulations revealed that the low-valent Au could append its 6s orbital into the band diagram of AuKPCN that formed a trapping level for generating highly localized holes under photoexcitation. These highly localized holes could boost the 1e−water oxidation reaction to form highly oxidative ·OH and simultaneously unbind the hydrogen atom in H2O molecule, which greatly promoted the hydrogenation process during the 2e−oxygen reduction reaction (ORR) to produce H2O2. The photogenerated ·OH on AuKPCN led to a more than 120-fold efficiency enhancement for visible-light-response superhydrophilicity as compared to that of the commercial TiO2. The onsite fixed-bed reactor under photo-illumination achieved a remarkable 132.5 LH2Om− 2day− 1water disinfection rate (lg6), which is about 30 times superior than the TiO2photocatalytic advanced oxidation process in the most ideal case (< 4 LH2Om− 2day− 1; lg4).
Dual role of ANGPTL8 in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis
Authors: Guo Xingrong , Gao Yujiu , Yuan Yue , Wen Shu , Chen Yanghui , Zhang Zongli , Feng Ying , Ma Shinan , Hu Rong , Fang Chen , Ruan Xuzhi , Yuan Yahong , Fang Xinggang , Luo Chao , Meng Zongji , Wang Xiaoli
Published: January 2023

The interplay between hepatocellular carcinoma (HCC) cells and the tumor microenvironment is essential for hepatocarcinogenesis, but their contributions to HCC development are incompletely understood. We assessed the role of ANGPTL8, a protein secreted by HCC cells, in hepatocarcinogenesis and the mechanisms through which ANGPTL8 mediates crosstalk between HCC cells and tumor-associated macrophages. Immunohistochemical, Western blotting, RNA-Seq and Flow cytometry analysis of ANGPTL8 were performed. A series of in vitro and in vivo experiments were conducted to reveal the role of ANGPTL8 in the progression of HCC. ANGPTL8expression was positively correlated with tumor malignancy in HCC, and high ANGPTL8 expression was associated with poor overall survival (OS) and disease-free survival (DFS). ANGPTL8 promoted HCC cell proliferation in vitro and in vivo, and ANGPTL8KO inhibited the development of HCC in both DEN-induced and DEN-plus-CCL4-induced mouse HCC tumors. Mechanistically, the ANGPTL8–LILRB2/PIRB interaction promoted polarization of macrophages to the immunosuppressive M2 phenotype in macrophages and recruiting immunosuppressive T cells. In hepatocytes, ANGPTL8-mediated stimulation of LILRB2/PIRB regulated the ROS/ERK pathway and upregulated autophagy, leading to proliferation of HCC cells. Our data support that ANGPTL8 has dual role of in promoting tumor cell proliferation and immune escape during hepatocarcinogenesis.
Venetoclax consolidation in high-risk CLL treated with ibrutinib for ≥1 year achieves a high rate of undetectable MRD
Authors: Thompson Philip , Keating Michael , Ferrajoli Alessandra , Jain Nitin , Peterson Christine , Garg Naveen , Wang Sa , Jorgensen Jeffrey , Kadia Tapan , Bose Prithviraj , Pemmaraju Naveen , Short Nicholas , Wierda William
Published: January 2023

Patients receiving ibrutinib for CLL rarely achieve undetectable measurable residual disease (U-MRD), necessitating indefinite therapy, with cumulative risks of treatment discontinuation due to progression or adverse events. This study added venetoclax to ibrutinib for up to 2 years, in patients who had received ibrutinib for ≥ 12 months (mo) and had ≥ 1 high risk feature (TP53 mutation and/or deletion, ATM deletion, complex karyotype or persistently elevated β2-microglobulin). The primary endpoint was U-MRD with 10− 4 sensitivity (U-MRD4) in bone marrow (BM) at 12mo. Forty-five patients were treated. On intention-to-treat analysis, 23/42 (55%) patients improved their response to CR (2 pts were in MRD + CR at venetoclax initiation). U-MRD4 at 12mo was 57%. Best rate of U-MRD4 was 33/45 (73%); 23/32 stopped ibrutinib; 9 continued ibrutinib. At a median of 41 months from venetoclax initiation, 5/45 patients have progressed; none have died from CLL or Richter Transformation. In 32 patients with BM U-MRD4, peripheral blood (PB) MRD4 was analyzed every 6 months; 10/32 have had PB MRD re-emergence at a median of 13 months post-venetoclax. In summary, the addition of venetoclax in patients treated with ≥ 12mo of ibrutinib achieved high rate of BM U-MRD4 and may achieve durable treatment-free remission.
Assessing carbon cycle projections from simple and complex models under SSP scenarios
Authors: Melnikova Irina , Ciais Philippe , Boucher Olivier , Tanaka Katsumasa
Published: January 2023

Both full-fledged Earth System Models (ESMs) and simple climate models (SCMs) have been used to investigate climate change for future representative CO2 concentration pathways under the sixth phase of the Coupled Model Intercomparison Project. Here we explore to what extent complex and simple models are consistent in their carbon cycle response in concentration-driven simulations. Although ESMs and SCMs exhibit similar compatible fossil fuel CO2 emissions, ESMs estimate lower ocean carbon uptake than SCMs in the historical period and future scenarios. Besides, ESMs and SCMs deviate in their land carbon uptake estimates, but the differences are scenario-dependent. The differences are partly driven by a few model outliers (ESMs and SCMs). They can also be attributed to the procedure of constraining SCMs with historical observations that is not applied to ESMs. The differences in land uptake arise from the difference in the way land-use change emissions are calculated and different assumptions on how the carbon-concentration (ꞵ) and carbon-climate (γ) feedbacks are defined. The discrepancy in the ꞵ feedback may reflect the treatment of nitrogen limitation of biomass growth by ESMs. The discrepancy in the γ feedback may reflect its heterogeneous spatial nature in ESMs, i.e., the γ feedback drives a carbon source in the low latitudes but may drive either a sink or source in the high latitudes. The differences in ocean uptake, which are especially large in overshoot scenarios, may arise from the faster mixing of carbon from the surface to the deep ocean in SCMs than in ESMs. We call the attention of climate modeling groups to these potential areas of model improvement.
Season, Storage and Extraction Method Impact on the Phytochemical Profile of Terminalia Ivorensis
Authors: Moomin Aliu , Russell Wendy R. , Knott Rachel M. , Scobbie Lorraine , Mensah Kwesi Boadu , Adu-Gyamfi Paa Kofi Tawiah , Duthie Susan J.
Published: January 2023

Background: Terminalia ivorensis (TI) is used in West African ethnomedicine for the treatment of conditions including ulcers, malaria and wounds. Despite its widespread use, the phytochemical profile of TI remains largely undetermined. This research investigated the effects of extraction method, season, and storage conditions on the phytochemical composition of TI to contribute towards understanding the potential benefits.
Methods: TI bark was collected in September 2014, September 2018 and February 2018 during the rainy or dry seasons in Eastern Region, Ghana. Samples were extracted sequentially with organic solvents (petroleum ether, chloroform, ethyl acetate and ethanol) or using water (traditional). Metabolites were identified by liquid chromatography–mass spectrometry/mass spectrometry and compared statistically by ANOVA.
Results: A total of 82 different phytochemicals were identified across all samples. A greater yield of the major phytochemicals (44%; p<0.05) was obtained by water as compared with organic extraction. There was also a higher concentration of metabolites present in cold (63%; p<0.05) compared with hot water extraction. A significantly (p<0.05) higher number of phytochemicals were identified from TI collected in the dry (85%) compared to the rainy season (69%). TI bark stored for four years retained 84% of the major phytochemicals.
Conclusions: This work provides important information on composition and how this is modified by growing conditions, storage and method of extraction informing progress on the development of TI as a prophylactic formulation or medicine.
AKR1B1 drives hyperglycemia-induced metabolic reprogramming in NAFLD-associated carcinogenesis and progression of hepatocellular carcinoma
Authors: NP Syamprasad , Jain Siddhi , Rajdev Bishal , Panda Samir Ranjan , Kumar Gangasani Jagadeesh , Shaik Khaja Moinuddin , Shantanu PA , Challa Veerabhadra Swamy , Vaidya Jayathirtha Rao , Tripathi Dinesh Mani , Naidu VGM
Published: January 2023

Objective
Emergent epidemiological evidence suggests that the progression of NAFLD/NASH-associated HCC positively correlates with the patient's glycemic index. However, the mechanism behind this progressive pathological alteration is poorly understood. It has shown that the polyol pathway master regulator, AKR1B1 is over-expressed in hyperglycemia and responsible for most of diabetic complications. Hence in the present study, we have investigated the role of AKR1B1 in metabolic switching associated with NAFLD/NASH and in the progression of HCC.
Methods
The expression of AKR1B1 in NAFL/NASH, HCC, and HCC with diabetes mellitus patient's liver and plasma were estimated. The role of AKR1B1 in the metabolic switching of HCC cell lines was assessed through media conditioning and lentiviral transfection. Standard inhibitor epalrestat or investigational drug NARI-29 (4-((Z)-5-((Z)-2-Cyano-3-phenylallylidene)-4-oxo-2-thioxothiazolidin-3-yl) benzoic acid) was utilized to elucidate the effect of AKR1B1 inhibition in hepatocarcinogenesis. A proteomic approach was applied for an in-depth investigation of the involved metabolic pathway and to evaluate the therapeutic efficacy of pharmacological inhibitors. Preclinically, a high fructose diet (HFrD) fed in combination with a diethyl nitrosamine (DEN) induced mouse model was developed to investigate the role of AKR1B1 in the hyperglycemia-mediated metabolic switching in the pathobiology of NAFLD and its progression to HCC.
Results
A significant increase in the expression of AKR1B1 was observed in NAFL/NASH, HCC, and HCC-DM tissue samples compared to non-involved adjacent tissues indicating its role in the disease progression. Moreover, a statistically significant elevation of AKR1B1 was observed in NAFLD, NAFLD-associated HCC, and HCC-DM plasma samples compared to normal control. Mechanistically, Invitro assays revealed that AKR1B1 modulates the Warburg effect, mitochondrial dynamics, TCA cycle, and lipogenesis to promote hyperglycemia-mediated fatty liver and cancer progression. A pathologically increased expression of AKR1B1 was observed in experimental NAFL-HCC, and expression was positively correlated with high blood glucose levels. HFrD + DEN-treated animals also exhibited statistically significant elevation of metabolic markers and carcinogenesis markers. However, AKR1B1 inhibition with EPS or NARI-29 has inhibited cellular metabolism in vitro and in vivo models.
Conclusion
Pathological AKR1B1 modulates hepatic glucose metabolism to promote NAFLD-associated hepato-carcinogenesis. Aldose reductase inhibition modulates glucose metabolism to prevent the pre-cancerous hepatocyte formation. Hence EPS and NARI-29 could be promising AKR1B1 inhibitors for controlling aberrant metabolism and treating NAFLD-associated HCC.
Allied Health Professionals’ experiences and views towards improving musculoskeletal services in the UK for patients with musculoskeletal and co-existing mental health conditions: a qualitative study
Authors: Maki Dana , Tehrany Rokhsaneh , Teixeira Maria J. C. , Chumak Tanya , Hoerz Christine
Published: January 2023

Background: Interplay between physical and mental health (MH) is widely recognised in patients with Musculoskeletal and co-existing MH conditions. Evidence suggests that psychological interventions improve outcomes and satisfaction in patients with physical conditions, however current healthcare models continue to separate physical and mental health care, as health services are fragmented. If the delivery of MH support could be facilitated by Allied Health Professionals (AHPs), such as physiotherapists and occupational therapists (OTs), this could be an effective, low-cost way to achieve routine integration. This study aimed to explore the experiences of UK physiotherapists and OTs working with patients with MSK and co-existing MH conditions and to understand views on improving MSK services.
Methods:This was an exploratory-descriptive qualitative study using semi-structured interviews. Participants were recruited via social media and professional organisations using purposeful sampling. Participants included registered UK physiotherapists or OTs within MSK settings who managed patients with MH conditions. Inductive thematic analysis was used, where single and double-level coding, single counting and inclusion of divergent cases were conducted to enhance methodological rigour.
Results: Three broad dimensions were identified. Dimension one referred to openness to provide MH support, with scope of practice and lack of confidence as themes. Dimension two described challenges, incorporating mental health stigma, the clinical environment, and limited experience. The third dimension referred to training, which identified the need for further training and strategies to implement as themes.
Conclusion: Many challenges to achieving optimal integration of physical and mental health care exist within MSK services. These challenges go beyond the need for additional training and knowledge acquisition and include departmental readiness such as funding, diary management, and supervision by senior colleagues/or psychologists, which need consideration in parallel to match the evolving needs of the MSK population.
Effects of Bipolar Disorder on Maternal and Fetal Health during Pregnancy: a systematic review with meta-analysis
Authors: Mohamed Malak A. , Elhelbawy Abdulrahman , Khalid Maria , AbdAllatif Latifa A. , Lialy Hagar E.
Published: January 2023

Background
Bipolar disorder, or manic-depressive illness, is a mental health condition characterized by mood shifts from severe depression to elevated mood or mania. Pregnant women with BD may experience manic or depressive episodes during gestation, delivery, or postpartum, so they are usually concerned about the effects of BD on their health and their fetal health. The aim of this systematic review is to determine the effects of BD on maternal health and fetal health, weight, and development. It also addresses how BD affects the probability of incidence of pregnancy and labor complications in women with bipolar compared to healthy controls.
Methods
Three electronic databases (Cochrane, PubMed, and ScienceOpen) were searched, and 1193 eligible studies were identified. After deduplication, screening, and manual search processes, we included only 7 studies. Descriptive analysis, meta-analysis, and calculation of the conditional probability of incidence for each pregnancy outcome were used to analyze the results.
Results
The findings of the included studies suggest that BD during pregnancy affects both fetal growth and maternal health by increasing the risk of giving birth to a neonate with some birth defects such as microcephaly, small for gestational age, and other congenital anomalies, in addition to causing some obstetric complications such as gestational hypertension, preterm labor, need for assisted delivery and others.
Conclusion
Bipolar disorder during pregnancy negatively affects mothers and their fetuses and increases the probability of incidence of obstetrics complications.
A Network medicine approach to study comorbidities in heart failure with preserved ejection fraction
Authors: Lanzer Jan David , Valdeolivas Alberto , Pepin Mark , Hund Hauke , Backs Johannes , Friederich Hans-Christoph , Schultz Jobst Hendrik , Saez-Rodriguez Julio , Levinson Rebecca Terrall
Published: January 2023

Background Comorbidities are expected to impact pathophysiology of heart failure (HF) with preserved ejection fraction (HFpEF). However, comorbidity profiles are usually reduced to a few comorbid disorders. Systems medicine approaches can model multiple comorbidities to help to improve our understanding of HFpEF.
Methods We retrospectively explored 569 comorbidities documented in 29,074 HF patients, including 8,062 HFpEF and 6,585 heart failure with reduced ejection fraction (HFrEF) patients from a German university hospital. To analyze comorbidity profiles, first we assessed differences between comorbidity profiles by HF subtype. We fit machine learning classifiers to discriminate between HFpEF and HFrEF patients to interpret important comorbidities. Then we built a network to represent comorbid relationships in HF patients (HFnet) and identified main disease clusters. Lastly, we performed novel gene candidate prediction for HFpEF by linking the HFnet to a multi-layer gene network by integrating multiple databases (HFhetnet). To corroborate HFpEF candidate genes, we collected transcriptomic data in a murine HFpEF model. We compared predicted genes with the murine disease signature as well as with the literature.
Results We found that comorbidity profiles vary more in association with HFpEF/HFrEF status than with age or sex. The comorbidities present in HFpEF patients were more diverse than those in HFrEF, and included neoplastic, osteologic and rheumatoid disorders, among others. Disease communities in the HFnet captured important comorbidity concepts of HF patients which could be assigned to HF subtypes, age groups and sex. Within the HFhetnet, we predicted novel gene candidates, including genes involved in fibrosis (COL3A1, MMP1, LOX), oxidative stress (NOS1, GSST1, XDH) and endoplasmic reticulum stress (ATF6). Finally, predicted genes were significantly overrepresented in the murine transcriptomic disease signature.
Conclusion We applied systems medicine concepts to analyze comorbidity profiles in a HF patient cohort. We were able to identify disease clusters that helped to characterize HF patients. We derived a distinct comorbidity profile for HFpEF, which was leveraged to suggest novel candidate genes via network propagation. The identification of distinctive comorbidity profiles and candidate genes from routine clinical data will provide insights that may be leveraged to improve diagnosis and treatment for HFpEF patients.
Digital Twins and Cultural Heritage Preservation: A Case Study of Best Practices and Reproducibility in Chiesa dei SS Apostoli e Biagio
Authors: Hutson James , Weber Joesph , Russo Angela
Published: January 2023

The use of digital twin technologies to preserve cultural heritage has become increasingly common over the past two decades. Evolving from the use of virtual environments (VE) and digital reconstructions that required multiple phases of workflow and multiple software applications and various hardware to output a useable experience to the immediacy of 3D artificial intelligence (AI) generative content and the latest generation of photogrammetric scanning, non-specialists are now able to more easily create digital twins. At the same time, destruction of cultural heritage has accelerated due to geopolitical instability, seen in examples such the invasion of Ukraine by Russia (2022). Even with advances in user-friendly and commercially available technologies, digital art history and the digital humanities are in a race against time to train and equip enough individuals onsite to create digital twins before more irreplaceable cultural artifacts and sites are lost to natural disaster, accelerated by climate change, or through armed conflict. However, there remains no international standards for methodological reproducibility and the techniques used currently by many scholars include specialized training and knowledge. As such, this paper presents a case study that addresses reproducibility and explainability in the digital humanities through a detailed workflow of the creation of a digital twin of Chiesa dei SS Apostoli e Biagio in Florence, Italy. A model is presented that is scalable and leverages widely available, user-friendly 360 cameras and photogrammetry with LiDAR to capture cultural heritage sites with best practices on how to quickly and effectively train non-specialists to create site-specific digital twins of a variety of cultural heritage structures.
The AT-hook is an evolutionarily conserved auto-regulatory domain of SWI/SNF required for cell lineage priming
Authors: Saha Dhurjhoti , Hailu Solomon , Hada Arjan , Lee Junwoo , Luo Jie , Ranish Jeff , Feola Kyle , Lin Yuan-chi , Jain Abhinav , Liu Bin , Lu Yue , Sen Payel , Bartholomew Blaine
Published: January 2023

The SWI/SNF ATP-dependent chromatin remodeler is a master regulator of the epigenome; controlling pluripotency and differentiation. Towards the C-terminus of the catalytic subunit of SWI/SNF is a motif called the AT-hook that is evolutionary conserved. The AT-hook is present in many chromatin modifiers and generally thought to help anchor them to DNA. We observe the AT-hook however regulates the intrinsic DNA-stimulated ATPase activity without promoting SWI/SNF recruitment to DNA or nucleosomes by increasing the reaction velocity a factor of 13 with no accompanying change in substrate affinity (KM). The changes in ATP hydrolysis causes an equivalent change in nucleosome movement, confirming they are tightly coupled. Attenuation of SWI/SNF remodeling activity by the AT-hook is important in vivo for SWI/SNF regulation of chromatin structure and gene expression in yeast and mouse embryonic stem cells. The AT-hook in SWI/SNF is required for transcription regulation and activation of state-specific enhancers critical in cell lineage priming. Similarly, the AT-hook is required in yeast SWI/SNF for activation of genes involved in amino acid biosynthesis and metabolizing ethanol. Our findings highlight the importance of studying SWI/SNF attenuation versus eliminating the catalytic subunit or completely shutting down its enzymatic activity.
Effects of Compulsory Upper-Secondary Education on Financial Inclusion
Authors: Park Eunjung , Yi Sangyoon
Published: January 2023

To enable sustainable financial inclusion, various policies are enforced internationally; however, there are diverse opinions on their effectiveness. Previous research has shown that education is necessary for individuals to understand financial products and services. Therefore, financial initiatives including financial education are considered crucial. This study aimed to analyze the effects of compulsory education on financial inclusion, from a variety of sociodemographic characteristics. We analyzed global data collected per country by the World Bank, the United Nations Development Programme, and the International Monetary Fund. It used an instrumental variable model that modelled the expected years of schooling and the human rights index as instruments. The results demonstrated that compulsory upper-secondary education had a positive effect on financial inclusion at all socioeconomic levels, except for people aged 60 years or older. For women, compulsory upper-secondary education had the greatest effect on financial inclusion. Contrastingly, we found that the completion of lower-secondary education was sufficient to promote financial inclusion in the high-income class, while other groups needed to complete their upper-secondary education at least. This study provides valuable insights to help establish feasible policies and strategies for the financial inclusion of the socially marginalized groups we are interested in.
Genetic diversity of Melia dubia as revealed by molecular markers
Authors: DARYAL UNSHANI , Dobhal Shivani , Kumar Ashok , Panwar Neha Singh
Published: January 2023

Background
Melia dubia Cav. of the family Meliaceae is a highly valued multipurpose tree species that has a short rotation period and can be harvested for various industrial and domestic wood requirements. However, the availability of genetically improved planting stock is almost non-existent, especially in North East India, and formulating management and conservation strategies are highly in need as it was observed during the survey that the number of Melia trees was very less and the majority of it was found fragmented in home-gardens.
Methods and Results
In the present study, a survey was conducted on the natural population in 11 villages of East Siang District, Arunachal Pradesh and 34 phenotypically superior Melia trees were selected based on the characteristics viz. height, clear bole height, girth at breast height, collar girth, crown diameter, straightness and branching. East Siang district of Arunachal Pradesh occupies a geographical area of 3,603 sq. km and a forest cover of 2911.67 sq. km. Genetic diversity of 34 selected trees is estimated with 15 microsatellite markers (SSR). Five out of fifteen SSR primers were found to be polymorphic. The effective number of alleles (Ne = 1.88), Nei’s gene diversity (h = 0.47), polymorphism information content (PIC = 0.48) and Shannon’s index (I = 0.66).
Conclusion
It is affirmed by the UPGMA dendrogram and the pair-wise genetic dissimilarity that there is no association between the genetic and geographic distance of the genotypes. Understanding the genetic variability of M. dubia will help to identify superior seed sources for improvement programs and conservation strategies for the species.
Male sterility and hybrid breeding in soybean
Authors: Fang Xiaolong , Sun Yanyan , Li Jinhong , Li Meina , Zhang Chunbao
Published: January 2023

Hybrid breeding can help us to meet the challenge of the growing world population with limited agricultural land. The demand for soybeans is expected to grow, however the hybrid soybean is still in the process of commercialization even though considerable progress has been made in soybean genome and genetic studies in recent years. Here, we summarize recent advances on male sterility-based breeding programs and the current status of hybrid soybean breeding. A number of male-sterile lines with cytoplasmic male sterility (CMS), genic-controlled photoperiod/ thermo-sensitive male sterility (GMS) and nuclear male-sterile mutants have been identified in soybean. More than 40 hybrid soybean varieties have been bred using the CMS three-line hybrid system and the cultivation of hybrid soybean still under way. The key to speed up hybrid soybean breeding is to increase the out-crossing rate in an economical way. This review outlines the problems with current hybrid soybean breeding systems and explores the current effort in making the hybrid soybean a commercial success.
Prevalence of undernutrition and change detection among under-five children of EAG states in India: scrutinizing from NFHS-4 and NFHS-5
Authors: Roy Arabinda , Rahaman Mostafijur
Published: January 2023

Background: Nowadays undernutrition among the under five children is a serious public health problem in the developing countries like India. There are EAG states in India which are socio-economically backward in term of demographic and epidemiological transition, characterized by high population growth rate, high infant child morality and high fertility. The current study was conducted to assess the changes of the indicator of undernutrition with the help of anthropometric measurement of under five children and represent the current (NFHS-5, 2019-21) prevalence of child undernutrition among the EAG states of India. Methods The state level data of undernutrition were extracted from state fact sheet of India, published by NFHS, India. The study is based on two time series of NFHS (NFHS-4 & NFHS-5. The changes of undernutrition indices in the EAG states were estimated by differentiate the last series prevalence from the previous series prevalence. Also thematic map were used to show spatial distribution of undernutrition indices of the latest NFHS series (NFHS-5). Result From the result it is found that the prevalence of stunting and underweight are decreased in all the EAG states and the decreasing pattern is more than the national level but the prevalence of wasting is only increased in Bihar. The NFHS-5 report shows that the prevalence of stunting and underweight in most of the EAG states has still more than 30%. Conclusions To reduce undernutrition among under-5 children there is need some target oriented policies which will help in improving the socio economic status of the children’s family as well as maternal and child health. Enhance the level of education of mothers, awareness and raising the economic as well as socio-political empowerment of mothers is essential to reduce the undernutrition status. This study will be beneficial for the health workers and policy makers to understand the prevalence and changing pattern of undernutrition among the children of EAG states.
WITHDRAWN: Estimating the Income of the January 6, 2021 Insurrectionists
Authors: Komlos John
Published: January 2023

The income of those who attacked the U.S. Congress on January 6, 2021 and were subsequently arrested is estimated using the income in the neighborhood of their residence as a proxy measure. Contrary to common wisdom, we find that the income of the arrestees was not at all similar to that of the population at large. Three groups were conspicuously underrepresented from this subset of the insurrectionists: the poor (whose annual personal income was below $20K), the upper-middle class, and the superrich. Fully 83% of the arrestees resided in areas with an average annual personal income between $20K and $50K. This finding dovetails with the argument that the right-wing populist movement is driven primarily by those who were left behind by the transition from an industrial to a post-industrial economy.
Behavior in Financial Management in a Demographic Analysis
Authors: Silva Erlon Andrade Da , Sodré Plínio Roberto Souza , Gomes Francinaldo Lobato , Cruz Laís Pinho
Published: January 2023

Purpose: Based on the analysis of the behavior in financial management (BFM) of a group of doctors who graduated from the State of Bahia, we investigated the differences in behavior in personal finances based on some demographic variables.
Methodology:In the population study, we used the Financial Management Behavior Scale (FMBS), plus demographic questions and scores tostratify and quantify the sample's BFM.
Findings:The comparison between the BFM of the different generations was not statistically relevant, possibly pointing to the changes that have been taking place both in medical demography and society. We found a statistically significant difference between the BFM in terms of gender and when we analyzed the profile of participation in the household's income about insurance adherence.
Social implications: The relativelylow total score of the BFM in the population studied is worrying and allows us to predict more alarming results for Brazilian demography.
JEL Codes: D91, I22, G5, A20, C92.
Effects of Curvature Direction on Friction Stir Welding Lap Joint of Aluminum Alloy "S" Curved Surface
Authors: Xiao Xuan , Mao Yue , Wang Xincheng , Qin Dingqiang , Fu Li
Published: January 2023

In this paper, the friction stir welding (FSW) of single-curvature and double-curvature "S" curved surface lap joints were realized using split type pressing blocks fixture and robotic system with welding parameter 1400rpm, 150mm/min. By Finite Element Method (FEM) and axial force analysis, the effects of curvature direction on friction stir welding lap joint of 5083 Aluminum Alloy "S" Curved surface is explored. The results show that Z-axis curvature direction has important influence on joint forming. By split type pressing blocks fixture, the material thermal expansion causes upward force F’ in Z-axis positive curvature position, but causes downward force F’ in Z-axis negative curvature position. So Z-axis positive curvature makes the actual axial compressive force FR (FR=FN-F’) smaller than the device input FN. Which decreases the interface stress of the lap joint and increases the tendency of upper plate edges bending deformation and the probability of interface defects. Finally, the joint mechanical properties are reduced, the tensile load can be as low as 1.5 kN. While Z-axis negative curvature makes the actual axial compressive force FR (FR=FN+F’) greater than the device input FN. Which increases the interface stress of the lap joint. Meanwhile it decreases the tendency of upper plate edges bending deformation and leads to the interface defects disappearing. So the joint mechanical properties are good, the tensile load can be more than 2.4 kN. For Y-axis curvature direction, its impact is mainly shown in changing the direction of resultant force FR. In Y-axis positive curvature position, the force FR lies between Y positive direction and Z negative direction. While in Y-axis negative curvature position, the force FR lies between Y negative direction and Z negative direction. The inclination of force FR is helpful to eliminate the interface defects of the joint. At the same time, it will cause inconsistent stress between the advancing side (AS) and the retreating side (RS) of the joint interface, which is the reason that the double-curvature lap joint welding process is unstable.
Theoretical study of the interaction of nanotubes with Venlafaxine, Azithromycin, Erythromycin and Ciprofloxacin
Authors: Raoufi Arastou , Kiaeefar Ali , Raoufi Amir Mahdi , Rajabi Negar , Ismailzadeh Amir
Published: January 2023

The current paper investigated Venlafaxine, Azithromycin, Erythromycin and Ciprofloxacin medications absorption properties interactions with single-walled carbon nanotubes (SWNT). All calculations were performed by using Gaussian 09 software. Calculations were applied to atoms using the B3LYP theory that is the famous function of DFT method and basis set 6-31G (d, p). The atoms are calculations were all performed at Quantum level. Using the above method, all systems’ degrees of freedom was optimized. It is worth noting that all calculations were carried out in the gas phase. The current paper investigated Van der Waals attraction of the medication on the SWNT (5, 5). Van der Waals was studied in the gas phase configuration. The binding energy depends on the group on which CNT is absorbed in Van der Waals attraction.
Impact of Disease Burden on Clinical Outcomes of AML Patients Receiving Allogeneic Hematopoietic Cell Transplantation: A Study from the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation.
Authors: Bazarbachi Ali , dalle iman abou , Labopin Myriam , schroeder thomas , Finke Jürgen , Stelljes Matthias , neubauer Andreas , Blaise Didier , Agha Ibrahim Yakoub , Salmenniemi Urpu , Forcade Edouard , Itälä-Remes Maija , Dreger Peter , Bug Gesine , Heuser Michael , Choi Goda , Brissot Eolia , Giebel Sebastian , Nagler Arnon , Ciceri Fabio , Mohty Mohamad , Kroeger Nicolaus , Passweg Jakob
Published: January 2023

Pre-transplant detectable measurable residual disease (MRD) is still associated with high risk of relapse and poor outcomes in acute myeloid leukemia (AML). We aimed at evaluating the impact of disease burden on prediction of relapse and survival in patients receiving allogeneic hematopoietic cell transplantation (allo-HCT) in first remission (CR1). We identified a total of 3202 adult AML patients, of these 1776 patients were in CR1 and MRD positive and 1426 patients were primary refractory at time of transplant. After a median follow-up of 24.4 months, non-relapse mortality and relapse rate were significantly higher in the primary refractory group compared to the CR1 MRD positive group (Hazards Ratio (HR)=1.82 (95% CI: 1.47-2.24) p<0.001 and HR=1.54 (95% CI: 1.34-1.77), p<0.001), respectively. Leukemia-free survival (LFS) and overall survival (OS) were significantly worse in the primary refractory group (HR=1.61 (95% CI: 1.44-1.81), p<0.001 and HR= 1.71 (95% CI: 1.51-1.94), p<0.001, respectively). Our real-life data suggest that patients in CR1 and MRD positive at time of transplant could still be salvaged by allo-HCT with a 2-year OS of 63%, if negative MRD cannot be obtained and their outcomes are significantly better than patients transplanted with active disease.
Mold-Free Self-Assembled Scalable Microlens Arrays with Ultrasmooth Surface and Record-high Resolution
Authors: Zhou Guofu , Liu Zhihao , Hu Guangwei , Huapeng Ye , Wei Miaoyang , Zhenghao Guo , Chen Kexu , Liu Chen , Tang Biao
Published: January 2023

Microlens arrays (MLAs) based on the selective wetting have opened new avenues for developing compact and miniaturized imaging and display techniques with ultrahigh resolution beyond the traditional bulky and volumetric optics. However, the selective wetting lenses explored so far have been constrained by the lack of precisely defined pattern for highly controllable wettability contrast, thus limiting the available droplet curvature and numerical aperture, which is a major challenge towards the practical high-performance MLAs. Here we report a mold-free and self-assembly approach of mass-production of scalable MLAs, which can also have ultrasmooth surface, ultrahigh resolution, and the large tuning range of the curvatures. The selective surface modification based on tunable oxygen plasma can facilitate the precise pattern with adjusted chemical contrast, thus creating large-scale microdroplets array with controlled curvature. The numerical aperture of the MLAs can be up to 0.3 and precisely tuned by adjusting the modification intensity or the droplet dose. The fabricated MLAs have high-quality surface with subnanometer roughness and allow for record-high resolution resolution imaging up to equivalently 2116 ppi, as we demonstrated. This study shows a cost-effective roadmap for mass-production of high-performance MLAs, which may find applications in the rapid proliferating integral imaging industry and high-resolution display.
Quantum dynamics of a driven parametric oscillator in a Kerr medium
Authors: Bolandhemmat E. , Kheirandish F.
Published: January 2023

In this paper, we first analyze a parametric oscillator with both mass and frequency time-dependent. We show that the evolution operator can be obtained from the evolution operator of another parametric oscillator with a constant mass and time-dependent frequency followed by a time transformation $t\rightarrow\int_0^t dt'\,1/m(t')$. Then we proceed by investigating the quantum dynamics of a parametric oscillator with unit mass and time-dependent frequency in a Kerr medium under the influence of a time-dependent force along the motion of the oscillator. The quantum dynamics of the time-dependent oscillator is analyzed from both analytical and numerical points of view in two main regimes: (i) small Kerr parameter $\chi$, and (ii) small confinement parameter $k$. In the following, to investigate the characteristics and statistical properties of the generated states, we calculate the autocorrelation function and the Mandel $Q$ parameter, and to more elaborate, we obtain the (quasi) probability distributions on phase space like Glauber-Sudarshan $P$-function and Husimi distribution as the nonclassicality criteria.
­­­MORC2 interaction with MAX contributes to the expression of Glycolytic enzymes,
Breast Cancer Cell Proliferation and Migration
Authors: Guddeti Rohith Kumar , Pacharla Himavani , Yellapu Nanda Kumar , Karyala Prashanthi , Pakala Suresh
Published: January 2023

Cancer cell proliferation is a high energy demanding process, where the cancer cells acquire the energy by high rates of glycolysis, and this phenomenon is known as the “Warburg effect”. Microrchidia 2 (MORC2), an emerging chromatin remodeler, is over expressed in several cancers including breast cancer, and found to promote cancer cell proliferation. However, the role of MORC2 in glucose metabolism in cancer cells remains unexplored. In this study, we report that MORC2 interacts indirectly with the genes involved in glucose metabolism via transcription factors MAX (MYC-associated factor X) and MYC. We also found that MORC2 colocalizes and interacts with MAX. Further, we observed a positive correlation of expression of MORC2 with glycolytic enzymes Hexokinase 1 (HK1), Lactate dehydrogenase A (LDHA) and Phosphofructokinase platelet type (PFKP) in multiple cancers. Surprisingly, the knockdown of either MORC2 or MAX not only decreased the expression of glycolytic enzymes but also inhibited breast cancer cell proliferation and migration. Together, these results demonstrate the involvement of the MORC2/MAX signaling axis in the expression of glycolytic enzymes and breast cancer cell proliferation and migration.
Development and feasibility of an oral health E-learning program for long-term Japanese overseas workers: A pilot randomized controlled trial
Authors: Sasayama Kiriko , Momoi Yasuko , Gilmour Stuart , Ota Erika
Published: January 2023

Background

This study aimed to assess the feasibility and acceptability of an oral health self-care e-learning intervention for overseas workers as well as the research procedures for a future controlled trial.

Methods

We randomly allocated participants to either the intervention (n = 47) or control (n = 51) group. The intervention group received a standardized leaflet plus a theory-based oral health e-learning program. The control group received only the standardized leaflet. We assessed health behaviour related to fluoride toothpaste use, knowledge, motivation, oral care self-efficacy, and oral health QOL. Chi-square and t test analyses were performed to make comparisons between the two groups. To adjust for the common effects observed in both groups, regression models were constructed using a difference-in-differences framework. To evaluate the research process, participants in the intervention group were asked open-ended questions, and themes relating to the acceptability of this program and how the research procedures and processes worked in practice were identified.

Results

A total of 82 participants were included in the analysis. There was a statistically significant improvement in some fluoride use behaviours (Intervention = 22, Control = 10; P < .001) and knowledge in the intervention group (Intervention = 72.69, Control = 57.97; P < .001). Of the 36 respondents in the intervention group, 27 (70.4%) said that the e-learning intervention had changed their behaviour.

Conclusion

The oral health self-care e-learning intervention had a favourable effect only on fluoride-use behaviour and knowledge. Next, this feasible and acceptable pilot study should be used with an appropriate sample size in a randomized controlled trial.
Trial registration
The trial protocol was registered with UMIN-CTR (ID: UMIN000045883) on 27/10/2021.