bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Metode Pembelajaran Field Trip dalam Menanamkan Pendidikan Akhlakul Karimah Pada Siswa Raudhatul Atfal di ar-Rohmany
Authors: Nur Imama Jamil  , Muhammada  , Ahmad Ma’ruf  , M. Anang Sholikhudin
Published: August 2024

Masalah yang terjadi dinegara kita saat ini sebenarnya tidak lepas dari persoalan perilaku akhlakul akrimah pada setiap siswa. Terlepas dari ajaran ilmu agama, jika pendidikan anak menyimpang dari akidah Islam dan tidak terkait dengan Allah, tidak diragukan lagi anak akan memperoleh nilai-nilai negatif. Bahkan, didorong oleh nafsu dan bisikan setan, dia akan mengikuti keinginannya.
Pendidikan anak usia dini memegang peranan yang sangat penting dan menentukan bagi perkembangan siswa dimasa depan, sebab pendidikan siswa merupakan filosofi bagi dasar kepribadian mereka. perlu untuk mengajarkan mereka untuk melakukan yang terbaik dan berharap bahwa mereka akan memiliki sifat terpuji di masa depan dan dapat menghindari perilaku tercela.
Selain proses pembelajaran yang berlangsung di lembaga pendidikan yang mencakup semua proses perkembangan fisik. Mengajarkan sikap siswa dan memberikan bimbingan atau petunjuk dengan Kesabaran diperlukan untuk pembentukan sikap. keteladanan, pembiasaan, dan Implementasi pendidikan akhlakul karimah yang merupakan proses yang panjang dan berkesinambungan. Dan semestinya pendidikan akhlak termasuk dalam materi yang harus diajarkan dan dikuasai serta direalisasikan oleh peserta didik dalam kehidupan sehari-hari. Oleh karena itu diperlukan pendidikan sejak dini, khususnya Pendidikan akhlak agar mereka terbiasa berperilaku baik dan mengikuti perintah Allah yang sesuai ajaran al-Qur’an dan Hadist.
Tanggung jawab berat yang haris dipikul oleh dunia pendidikan akhirnya memunculkan tuntutan bagi lembaga pendidikan untuk meweujudkan cita-cita untuk membekali peserta didik dengan pendidikan akhlak. Oleh karena itu tulisan ini memberikan wawasan tentang bagaimana cara menanamkan nilai-nilai pendidikan akhlakul karimah melalui pembelajaran metode field trip di ar-Rohmany
Konsep Project Penguatan Profil Pelajar Pancasila dan Profil Pelajar Rahmatan Lil Alamin (P5 PPRA) dalam Kurikulum Merdeka
Authors: Muthoharoh Miftakhul
Published: August 2024

Project Penguatan Profil Pelajar Pancasila dan Profil Pelajar Rahmatan Lil Alamin (P5 PPRA) merupakan program yang diinisiasi oleh pemerintah untuk memperkuat pemahaman nilai-nilai pancasila dan ajaran islah dikalangan siswa untuk menghadapi berbagai tantangan yang semakin kompleks dalam pendidikan di Indonesia. Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis Project Penguatan profil Pelajar Pancasila dan Profil Pelajar Rahmatan Lil Alamin (P5 PPRA) yang diterapkan dalam kurikulum merdeka. Penelitian ini merupakan penelitian kajian pustaka. Hasil penelitian ini menjelaskan bahwa Profil Pelajar Pancasila dan Profil Pelajar Rahmatan Lil Alamin (P5 PPRA) bisa dilaksanakan melalui kegiatan intrakurikuler, ekstrakurikuler, kokurikuler, dan budaya madrasah.
Perceptions of Inequality and Attitudes towards Income Redistribution Policies in Russia
Authors: Kislitsyna Olga
Published: August 2024

Economic inequality is a fundamental social problem. Government’s policies to redistribute income can mitigate growing economic inequality through taxes and social transfers. However, attempts to introduce alternative tax schemes regularly face significant political resistance. This study tries to answer the following questions: (i) What do Russians think about economic inequality, inequality of opportunity, and the role of government in mitigating problems associated with inequality? (ii) What individual characteristics determine people's preferences regarding government’s redistributive policies? (iii) How are perceptions of economic inequality and inequality of opportunity related to people's attitudes toward government’s redistributive policies? Data from the Social Inequality Module of International Social Survey Program (ISSP) conducted in 2019 were used. Statistical analysis was performed using ordinal logistic regression models. The results allowed us to draw a number of conclusions. Firstly, it has been established that government’s policy to limit existing inequality enjoys fairly broad support among the population. Secondly, it has been proven that public support for redistribution policies in Russia can come from two sources: (1) personal interest related to people’s own socio-economic or other condition, and (2) social beliefs. The consequences of social beliefs about inequality may be more important than the effects of socio-economic status (SES): even people with high SES may support progressive tax policies when they recognize the importance of inequality. Thirdly, it is shown that among individual socio-demographic factors, the decisive ones in the process of forming attitudes towards redistribution policies are gender, age, marital status, level of religiosity, and political beliefs.
Implementation and Outcomes of Social Policy Reforms of Early 2000s in Russia: Reassessment in Retrospect
Authors: Dmitriev Mikhail
Published: August 2024

The article considers the original plans, implementation and outcomes of social policy reforms initiated in late 1990s — early 2000s in the areas of labor market, social security, pensions, and health. For each of these areas the author regards the initial goals, implementation level and attainment of the goals, as well as a follow up transformation of policy agenda. In all the four areas implementation level of key policy measures was rather low. By this criterion, no one of the reforms could be regarded fully successful. However, the degree of attainment of initial goals, at least in 3 of these areas, proved to be much higher than the level of policy implementation suggests. Very high economic growth during 2000s was, perhaps, the most important contributor to the attainment of the goals. High economic growth led to accelerated poverty alleviation and reduction of unemployment, facilitated increases of pensions and public fi nancing of health care. Nowadays, in the context of newly emerging opportunities and threats, such as population ageing, policy agenda in all of the four areas is shift ing towards new priorities, whereas many of non-implemented policy measures from the repertoire of the early 2000s seem to be less important or even outdated.
Religious Blasphemy, Jungle Justice, and Legal Pluralism in Northern Nigeria: A Comparative Analysis of the Nigerian 1999 Constitution and Sharia Law
Authors: A. V. Ishola,
Published: August 2024

This study investigates the legal and social implications of the divergent frameworks of the Nigerian 1999 Constitution and Sharia law in Northern Nigeria, focusing on religious blasphemy and jungle justice. The problem stems from the coexistence of these two legal systems, resulting in significant conflicts and ambiguities that undermine the effective administration of justice and the protection of fundamental human rights. Accusations of religious blasphemy often lead to jungle justice, where mobs bypass formal legal procedures to mete out extrajudicial punishments, deepening communal divisions and eroding public trust in the judicial system. Guided by John Rawls’s Theory of Justice, the study employs a descriptive research design to explore these issues in-depth. Data were collected in Kano and Sokoto states using purposive and stratified random sampling techniques. Key Informant Interviews (KIIs) and In-Depth Interviews (IDIs) with community leaders, religious leaders, legal practitioners, and civil society organizations were conducted, supplemented by secondary sources such as books, journal articles, and online publications. Content analysis was used to analyse the data. The findings reveal that the Nigerian Constitution, which guarantees freedoms of thought, conscience, religion, and expression, often clashes with Sharia law, which prescribes severe penalties for blasphemy. This divergence contributes to jungle justice as communities, frustrated with the formal legal system’s inadequacies, resort to extrajudicial actions. Efforts to harmonize these frameworks face challenges, including conflicting legal philosophies, cultural and religious sensitivities, jurisdictional ambiguities, and human rights concerns. The study therefore recommends an urgent need for legislative reforms, judicial clarity, cultural sensitivity and strengthening legal institutions.
La asamblea constituyente española y su resultado constitucional
Authors: Contreras Ugarte Jesús Víctor Alfredo
Published: August 2024

Actualmente, sobre todo en países de América, se habla de la necesidad de un cambio de Constitución a través de una asamblea constituyente. Esto, porque se evidencia que, en estos países, hay un cambio de tendencia hacia la ideología de izquierdas que, en honor a la verdad, advierte de cierto interés, apoyo y concierto –que más parece un contubernio internacional de cierto sector– que rebasa el ámbito nacional de cada país. Es esta ideología, sobre todo en los países iberoamericanos, la que promueve, hoy, el cambio total de sus constituciones, habilitando e intentando la aceptación y elección de una asamblea constituyente que permita un cambio radical en busca de sus fines. Chile y Perú son buenos ejemplos de este fenómeno actual. En tal contexto internacional, este trabajo analiza lo que fue el proceso constituyente español y su resultado, es decir, lo que es hoy la Constitución de 1978...
"Unborn Human Life and Fundamental Rights Leading Constitutional Cases Under Scrutiny"
Authors: Farfán Bertrán María Laura
Published: August 2024

Zambrano, Pilar and William L. Saunders (coords.), "Unborn Human Life and Fundamental Rights Leading Constitutional Cases Under Scrutiny", Berlin, Peter Lang GmbH, 2019, 264 pp.
Jueces haciendo política: La redefinición del concepto de "ciudadanía"
Authors: Silva Irarrázaval Luis Alejandro , Díaz Sáez Gustavo Adolfo
Published: August 2024

La sentencia Casilla con Junji, dictada por la Corte Suprema, es un acto de lo que podemos llamar “judicialización de la política”. Lejos del papel que corresponde a un tribunal de justicia, en esta sentencia se advierte un verdadero acto legislativo, por cuanto se redefine el concepto de ‘ciudadanía’ consagrado en la Constitución, trastocando con ello parte de la legislación. El propósito de este comentario es proyectar las consecuencias de esta decisión, y mostrar cómo esta sentencia representa una intromisión de los jueces en un asunto de naturaleza política.
ENGLISH LANGUAGE LEARNING IN ELEMENTARY SCHOOLS USING DIGITAL LEARNING MEDIA TO SUPPORT THE IMPLEMENTATION OF THE CURRICULUM MERDEKA
Authors: WAZIANA WINIA , ANDEWI WIDI
Published: August 2024

This research aims to find out the role of digital-based learning as a support for English language learning in the Merdeka Curriculum. This research is a type of qualitative research with a literature study approach. The research results show that digital media in elementary school-level English learning makes it easier and faster for teachers to present learning material so that it can be understood by students. Through digital learning media, teachers can hone their teaching skills. Learning that is provided in an innovative and fun way using digital media will be more easily accepted and absorbed by students.
CLINICAL CHARACTERISTICS AT HOSPITAL ADMISSION OF 5382 PATIENTS POSITIVE FOR SARS-CoV-2: A SINGLE CENTER RETROSPECTIVE STUDY FROM CENTRAL NORTHERN BULGARIA
Authors:   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Sredkova Mariya , Popov Cvetan ,   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Golemanov Georgi ,   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Nankov Vladislav ,   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Tonchev Pencho ,   Department of Surgical Nursing, Faculty of Health Care, Medical University - Pleven, Bulgaria., Blazhev Alexander ,   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Delcheva Valeri ,   Virology Laboratory, Institute of Science and Research, Medical University - Pleven, Bulgaria., Tomov Slavcho ,   Institute of Science and Research, Medical University - Pleven, Bulgaria.
Published: August 2024

Purpose: To describe age- and sex-related differences in COVID-19 symptoms in patients admitted to emergency departments during the four waves of the pandemic in Central Northern Bulgaria Materials and methods: Retrospective analysis of data collected from 5382 outpatients with positive result for SARS-CoV-2 by RT-PCR, admitted to 11 emergency departments in Central Northern Bulgaria, was carried out. Results: The median age of patients was 64 years, and 60.6% of them were old adults (≥ 60 years). Overall, more patients were males (51.8%) than females (48.2%). The most frequent symptoms were fever (84.8%), dyspnea (72.3%), and cough (69.9%) without significant difference in both sexes. Less common symptoms, such as sore throat, headache, loss of taste/smell, and fatigue, were found in 1.3% to 4.0% of patients and were more prevalent in women (p≤0.01). Fever remained constant, leading symptom in all ages. The incidence of cough and dyspnoea was less in young patients and showed an increase in middle-aged and old adults. Loss of taste and smell, muscle pain and fatigue displayed the opposite trend. For the leading symptoms, the male/female ratio was >1 in all age groups, whereas for all less common symptoms, this ratio was <1. Conclusions: Older age, male sex and cardiovascular disease were major risk factors for COVID-19 infection. Fever, dyspnoea and cough were the core symptoms and were more prevalent in men and in adult patients. The less common symptoms were more frequent in young people and women.
HAND-ARM VIBRATION SYNDROME IN WORKERS EXPOSED TO PROLONGED VIBRATION
Authors:   Department of Hygiene, Medical Ecology, Occupational Diseases and Disaster Medicine, Faculty of Public Health, Medical University - Pleven, Bulgaria., Stoilova Irena , Kostadinova Penka ,   Department of Social Medicine and Health Management, Faculty of Public Health, Medical University - Pleven, Bulgaria., Birdanova Vanya ,   Department of Hygiene, Medical Ecology, Occupational Diseases and Disaster Medicine, Faculty of Public Health, Medical University - Pleven, Bulgaria., Kamburova Mariela ,   Department of Social Medicine and Health Management, Faculty of Public Health, Medical University - Pleven, Bulgaria.
Published: August 2024

Industrial vibrations are the cause of hand-arm vibration syndrome, characterized by a polymorphic clinical picture. The aim of the study is to improve the diagnostics, treatment and prevention of hand-arm vibration syndrome in workers. Material and methods: The object of the study are 65 cases of hand-arm vibration syndrome in workers of enterprises in Northern Bulgaria. The persons were hospitalized in the Department of Occupational Diseases, University Hospital - Pleven in the period 2019 - 2023. The group was related with a length of service of more than 5 years. Clinical, laboratory, functional, imaging and statistical methods were applied. Results and discussion: The impairments of the examined persons are expressed in four clinical syndromes: neurological, vascular, bone-joint-muscular and auditory-vestibular. Socially significant diseases were found in 91% of the examined persons. Conclusions: Hand-arm vibration syndrome is a current health problem for workers in various branches of production in Bulgaria. Damage to persons exposed to long-term (more than 5 years) vibration exposure is manifested by a variety of clinical symptoms, summarized in four main syndromes - neurological, vascular, bone-joint-muscular and auditory-vestibular. Individuals in the first to second and second stages of vibration disease predominate among the studied contingent of workers. Prolonged vibration exposure predisposes to socially significant diseases such as diabetes mellitus, coronary heart disease, arterial hypertension, etc.
Osteomielitis crónica mandibular. Informe de dos casos clínicos

//Chronic mandibular osteomyelitis. A report of two clinical cases
Authors: Méndez Graciela Inés , Villanueva Ivana Noelia
Published: August 2024

Objetivo: Presentar dos casos clínicos inusuales de osteomielitis crónica en mandíbula, su resolución quirúrgica y destacar los aspectos clínicos, radiológicos e histológicos más relevantes.

Casos clínicos: Se reportaron dos casos clínicos de pacientes con osteomielitis crónica en mandíbula que acudieron al Servicio de Odontología del Hospital Interzonal General de Agudos “Eva Perón”. El primero fue un raro caso de osteomielitis ubicada de forma aislada en el cóndilo mandibular izquierdo. El tratamiento consistió en la resección quirúrgica del cóndilo mandibular afectado, seguido de terapia antibiótica a largo plazo. El segundo caso clínico se trató de un paciente con pericoronaritis asociado a un tercer molar inferior impactado. El tratamiento se basó en el desbridamiento quirúrgico más la colocación de drenaje, seguido de terapia antibiótica.

En ambos pacientes el diagnóstico de osteomielitis se confirmó mediante el estudio histológico de las muestras quirúrgicas, y tras seguimiento de 24 y 12 meses para el caso 1 y 2 respectivamente, no se han reportado recurrencias de la patología.

//Aim: To present two unusual cases of chronic mandibular osteomyelitis, its surgical resolution and highlight the most relevant clinical, radiological and histological aspects.

Clinical cases: Two clinical cases of patients with chronic mandibular osteomyelitis who attended the Dentistry Service of the “Eva Perón” Interzonal General Acute Hospital were reported. The first was a rare case of osteomyelitis located isolated in the left mandibular condyle. Treatment consisted of surgical resection of the affected mandibular condyle, followed by long-term antibiotic therapy. The second clinical case was a patient with pericoronitis associated with an impacted lower third molar. Treatment was based on surgical debridement and drain placement, followed by antibiotic therapy. In both patients the diagnosis of osteomyelitis was confirmed by histological study of the surgical samples, and after follow-up of 24 and 12 months for cases 1 and 2 respectively, no recurrences of the pathology have been reported.
Pengaruh Social Campaign Terhadap Brand Loyalty dengan Brand Image Sebagai Variabel Intervening Pada Kopi Kalyan
Authors: Lestari Ardisa Dwi Putri , Astono Anjar Dwi
Published: August 2024

This study explains the influence of Social Campaign on Brand Loyalty with Brand Image as an intervening variable. This study used a quantitative approach by distributing questionnaires to 140 respondents which were then processed using the SPSS 26 program. Sampling used a non-probability sampling technique with purposive sampling. The results of the hypothesis test show that Social Campaign has a significant effect on Brand Image, while Brand Image has a significant effect on Brand Loyalty. However, the Social Campaign has no direct effect on Kopi Kalyan's Brand Loyalty, but requires mediation from Brand Image. Based on the results of hypothesis testing, the indirect effect of Social Campaign on Brand Loyalty through Brand Image is 40.7%. The implications of this research can provide input so that Kopi Kalyan can pay attention to the factors that influence Brand Loyalty and their brand image.
Pengaruh Citra Merek Dan Kualitas Produk Terhadap Kepuasan Konsumen Sepatu Sepakbola Nike di Jakarta Timur
Authors: Wou Wilfridus , Iskandar Donant Alananto
Published: August 2024

This study aimst determine whether there is an influence between Brand Image and Product Quality on Consumer Satisfaction of Nike soccer shoes in East Jakarta. This study uses aquantitative method approach through a surveyy of 130 Nike soccer shoes users. The sampling method is non-probability sampling with purposive sampling type with the number of respondents 130 respondents,the data collection technique is a questionnaire. Thedata processing method uses linear regression analysis with the help of SPSS version 25 program. The results of this study conclude that Brand Image and Product Quality have a simultaneous and significant effect on Consumer Satisfaction.
Pengaruh Content Marketing Terhadap Minat Beli Dan Emotional Marketing Sebagai Variabel Intervening
Authors: Renwarin Joseph M. J. , Kamalsyah Ferry
Published: August 2024

Pocari Sweat advertises using anime media and gets 15 million views on YouTube, from the pre-survey it is known that respondents are interested in anime advertising rather than the advertising product. This study aims to find out how much Content Marketing has an effect on Purchase Intention, how much Content Marketing has an effect on Emotional Marketing, how much Emotional Marketing has an effect on Purchase Intention and how much Emotional Marketing intervenes in the influence of Content Marketing on Purchase Intention. This research method uses a quantitative approach method and the Probability Sampling method in sampling respondents. The results of this study are content marketing has a positive and significant relationship to Purchase Intention, content marketing has a positive and significant relationship to emotional marketing, emotional marketing has a positive and significant relationship to Purchase Intention, Emotional Marketing intervenes in the influence of Content Marketing on Buying Interest by The value of the indirect influence of Content Marketing through Emotional Marketing on Purchase Interest is 0.363 > from the direct influence with a value of 0.273
El cónyuge viudo como heredero forzoso especial y la colación hereditaria
Authors: Rodríguez Martínez María Eugenia
Published: August 2024

El art. 807. 3 CC establece que el viudo es un heredero forzoso distinto de los demás.No obstante, surgen dudas sobre la aplicación al mismo de normas dispuestas paraotros legitimarios. Parece acertada la tesis, mayoritaria en doctrina y jurisprudencia,que excluye al viudo de la obligación de colacionar la donación recibida del cónyugepremuerto, si bien requiere ciertas precisiones. Una reflexión sobre las cuestiones queorigina este problema contribuye a considerar los derechos del cónyuge en tiempos derevisión de las legítimas.
Optimizing postsurgical recovery for elderly patients with gastric cancer
Authors: Isah Adamu D , Shaibu Zakari , Dang Sheng-Chun
Published: August 2024

Based on a recent study by Li et al , this editorial examines the significance of enhanced recovery after surgery (ERAS) protocols for elderly patients with gastric cancer. Cancer-related mortality, which is overwhelmingly caused by gastric cancer, calls for effective treatment strategies. Despite advances in the field of oncology, conventional postoperative care often results in prolonged hospital stays and increased complications. The aim of ERAS is to expedite recovery, reduce surgical stress, and improve patient satisfaction. The study of Li et al showed that, compared to traditional care, ERAS significantly reduces mortality risk, shortens hospital stays, and decreases postoperative complications. These findings support the widespread implementation of ERAS protocols in surgical practice to enhance patient outcomes and healthcare value.
Immunosuppressive tumor microenvironment in gastric signet-ring cell carcinoma
Authors: Xie Yu-Qiong , Li Chun-Chun , Yu Mei-Rong , Cao Jiang
Published: August 2024

Gastric signet-ring cell carcinoma (GSRCC) is a subtype of gastric cancer with distinct phenotype and high risk of peritoneal metastasis. Studies have shown that early GSRCC has a good prognosis, while advanced GSRCC is insensitive to radiotherapy, chemotherapy or immune checkpoint blockade therapy. With technological advancement of single-cell RNA sequencing analysis and cytometry by time of flight mass cytometry, more detailed atlas of tumor microenvironment (TME) in GSRCC and its association with prognosis could be investigated extensively. Recently, two single-cell RNA sequencing studies revealed that GSRCC harbored a unique TME, manifested as highly immunosuppressive, leading to high immune escape. The TME of advanced GSRCC was enriched for immunosuppressive factors, including the loss of CXCL13 +-cluster of differentiation 8+-Tex cells and declined clonal crosstalk among populations of T and B cells. In addition, GSRCC was mainly infiltrated by follicular B cells. The increased proportion of SRCC was accompanied by a decrease in mucosa-associated lymphoid tissue-derived B cells and a significant increase in follicular B cells, which may be one of the reasons for the poor prognosis of GSRCC. By understanding the relationship between immunosuppressive TME and poor prognosis in GSRCC and the underlying mechanism, more effective immunotherapy strategies and improved treatment outcomes of GSRCC can be anticipated.
Navigating emotional challenges: A journey with patients undergoing chemotherapy
Authors: Pandey Nisha Mani , Ramakant Pooja
Published: August 2024

A recent article reported that cancer patients with subthreshold depression are more likely to develop major depression within a year. Multivariate regression analysis revealed that regular exercise was a protective factor against cancer-related fatigue, whereas advanced age, radiotherapy, pain, and low hemoglobin were risk factors for cancer-related fatigue. A limitation of this study was the lack of methodological details about leukemia patients receiving depressive treatment at a specific hospital. Professional assessment, behavioral modification plans, communication, destressing techniques, and educational plans may help chemotherapy patients manage emotional issues and reduce anxiety. Furthermore, these strategies can inspire patients to create, facilitate their treatment, and help them to remain healthy.
Successful cetuximab rechallenge in metastatic colorectal cancer: A case report
Authors: Guedes Alexandra , Silva Sandra , Custódio Sandra , Capela Andreia
Published: August 2024

BACKGROUND

Metastatic colorectal cancer (mCRC) treatment has been evolving and increasingly driven by tumor biology and gene expression analysis. Rechallenge with epidermal growth factor receptor (EGFR) inhibitors (anti-EGFR) represents a promising strategy for patients with RAS wild-type (RAS-wt) mCRC and circulating tumor DNA has emerged as a potential selection strategy. Herein, we report the case of a RAS-wt mCRC patient who had a successful response to cetuximab rechallenge.

CASE SUMMARY

Our patient was diagnosed with stage IV RAS-wt, microsatellite-stable rectosigmoid junction adenocarcinoma. He was started on first-line treatment with FOLFIRI and cetuximab and achieved partial response, allowing for a left hepatectomy (R0), followed by post-operative chemotherapy and an anterior resection; progression-free survival (PFS) of 16 months was obtained. Due to hepatic and nodal relapse, second-line treatment with FOLFOX and bevacizumab was started with partial response; metastasectomy was performed (R0), achieving a PFS of 11 months. After a 15 months anti-EGFR-free interval, FOLFIRI and cetuximab were reintroduced upon disease progression, again with partial response and a PFS of 16 months. Following extensive hepatic relapse, cetuximab was reintroduced and a marked clinical and analytical improvement was seen, after only one cycle. RAS-wt status was confirmed on circulating tumor DNA. The patient’s overall survival exceeded 5 years.

CONCLUSION

Our case provides real-world data to support cetuximab rechallenge in later lines of RAS-wt mCRC treatment.
Large-cell neuroendocrine carcinoma of the bladder: A case report
Authors: Zhou Yu , Yang Lin
Published: August 2024

BACKGROUND

Bladder neuroendocrine tumors are few and exhibit a high degree of aggressiveness. The bladder is characterized by four distinct forms of neuroendocrine tumors. Among them, large-cell neuroendocrine carcinoma is the least prevalent, but has the highest level of aggressiveness. The 5-year survival rate for large-cell neuroendocrine carcinoma of the bladder is exceedingly poor. To date, only a few dozen cases have been reported.

CASE SUMMARY

Here, we report the case of a 65-year-old man with large-cell neuroendocrine carcinoma of the bladder. The patient presented to the Department of Urology at our hospital due to the presence of painless hematuria without any identifiable etiology. During hospitalization, abdominal computed tomography revealed the presence of an irregular mass on the right anterior wall of the bladder. A cystoscopic non-radical resection of the bladder lesion was performed. The postoperative pathological examination revealed large-cell neuroendocrine bladder cancer. Previous reports on cases of large-cell neuroendocrine carcinoma cases were retrieved from PubMed, and the present paper discusses the currently recognized best diagnostic and treatment options for large-cell neuroendocrine carcinoma based on the latest research progress.

CONCLUSION

Large-cell neuroendocrine carcinoma of the bladder is an uncommon malignancy with a highly unfavorable prognosis. Despite ongoing efforts to prolong patient survival through multidisciplinary therapy, the prognosis remains unfavorable. Large-cell neuroendocrine carcinoma continues to be a subject of uncertainty.
Ventilator associated or induced lung injury. Does the name matter? Point and counterpoint
Authors: Fajardo-Campoverd Aurio , Daoud Ehab
Published: August 2024

The terminology used to describe lung injuries in patients receiving mechanical ventilation has significant implications for clinical practice, research, and communication among healthcare professionals. This point-counterpoint discussion paper explores the debate over the appropriate term to use: "ventilator-associated lung injury" (VALI) or "ventilator-induced lung injury" (VILI). The first author argues in favor of the term "ventilator-associated lung injury” from epistemology, philosophy, epidemiology and statistics, seems to correctly substantiate the relationship between lung injury as a consequence of inadequate mechanical ventilator programming. According to this perspective, "associated" more accurately reflects the complex interplay of these elements, which together contribute to the development of lung injury in ventilated patients. The second author advocates for the term "ventilator-induced lung injury," underscoring the direct causative role of mechanical ventilation in the development of lung injuries. This perspective highlights the specific pathological changes that result directly from mechanical ventilation strategies. According to this prospective "induced" is considered a more precise term, attributing the injury directly to the intervention of mechanical ventilation. Through this exchange, the authors provide a comprehensive analysis of the clinical and scientific implications of each term, ultimately seeking to guide consensus in the field regarding the most accurate and useful terminology. Keywords: VALI, VILI
Potential beneficial patient-ventilator dyssynchrony: is it possible?
Authors: Gallardo Adrian , Nunez Juan , Silvero Aldana , Diaz Armando
Published: August 2024

Patient-ventilator dyssynchronies are entities commonly observed during mechanical ventilation. Their persistence can be injurious to lung tissue and the diaphragm. However, these entities have shown different clinical impacts, with reports of diaphragm function preservation in the presence of reverse trigger. Therefore, we hypothesize the existence of a potentially beneficial dyssynchrony. Keywords: Dyssynchronies, Reverse trigger
Enhancing Oral Health Literacy- A Comprehensive Review
Authors: Adil Abdul Habeeb
Published: August 2024

Background

Oral health literacy (OHL) is an integral aspect of public health, necessary for individuals to make well-informed choices about their dental health. There is a correlation between low OHL and negative oral health outcomes, such as increased prevalence of periodontal disease, dental caries, and tooth loss. Understanding and improving OHL is vital for reducing health disparities and promoting equity in oral health care. This review aims to examine the current state of OHL research, evaluate the effectiveness of different interventions designed to improve OHL, and provide recommendations for future initiatives.

Materials and Methods

A thorough literature search was performed utilizing databases including MEDLINE, Scopus, PubMed, and the Cochrane Library. The search included keywords related to OHL, oral health disparities, preventive dental practices, and oral health outcomes. Studies published in English from 2000 to 2024 were included. Data extraction focused on study design, population characteristics, OHL measurement tools, interventions, and outcomes.

Results

From 1500 initial articles, 300 were screened, and 15 met the inclusion criteria. These studies covered various aspects of OHL, including measurement tool development, intervention evaluations, and the association between OHL and outcomes of oral health. Key findings indicated that higher OHL is related with improved oral health actions and outcomes, and targeted interventions can significantly improve OHL.

Conclusions

Improving OHL is essential for enhancing oral health outcomes and reducing disparities. Effective interventions include educational programs, community-based initiatives, and culturally sensitive communication strategies. Future research should focus on developing standardized measurement tools and evaluating the long-term impact of OHL interventions.
The nexus between socio-demographic factors and participation of special groups in public procurement of works in local government authorities
Authors:   College of Business Education, Ryoba Ester , Kisinga Debora ,   College of Business Education, Msacky Richard ,   College of Business Education
Published: August 2024

Examining the nexus between socio-demographic factors and the participation of special groups in the public procurement of work is essential to inform policymakers and stakeholders in the Local Government Authorities (LGAs) in Tanzania about the need for targeted initiatives to promote and enhance the participation of youths, women, the elderly and people with disabilities who are considered as special groups in public procurement. In this study, a cross-sectional research design was used, and a simple random sampling technique was applied to select 164 respondents. A questionnaire survey was conducted among employees in LGAs, drawing insights from Dodoma, a city in Tanzania. The data were analyzed using descriptive and binary logistic regression analysis. The findings revealed a low level of participation of special groups in the public procurement of works. Further analysis showed that sex and age are significantly associated with the participation of special groups in the public procurement of works. The study recommends that LGAs provide targeted support to special groups to help them participate in public procurement of works. This can include training and capacity-building programs and financial support to help them meet the procurement requirements of works. In addtion, it is recommended that policymakers take a leading role in reviewing and strengthening the existing legal framework and policies related to participation in public procurement in Tanzania. This includes ensuring that the laws and regulations explicitly promote the participation of special groups.
Curriculum and gender spaces in high schools in Eswatini
Authors:   University of KwaZulu-Natal, Makamure Gibson , Mpofu Phumuzani ,   University of Witwatersrand
Published: August 2024

This article makes a social constructionist exploration of student experiences of socially constructed curriculum in school spaces in high schools in Eswatini. The study utilised a qualitative narrative inquiry methodology. Individual semi-structured interviews and focus group were used to generate data. The participants were 24 purposively selected students (12 boys and 12 girls) from four high schools in Hhohho region. Participants ranged in age from 16 to 18 years. Contexts of subject knowledge and socially constructed curricula have shaped ideas about what constitutes a suitable education for girls and boys, as well as what subjects they should study. Subject suitability criteria have evolved, but there are still strong curriculum roots that drive the gender problem and disparities in accomplishment, where specific information has historically been associated with various groups. The study found that learners in other schools were free to choose subjects according to their abilities and without any influences from teachers. In those schools, girls even took up subjects perceived to be masculine, like agriculture and technical drawing. However, in other schools, teachers heavily influenced the subjects the learners chose. In most cases, the subjects were chosen according to femininity and masculinity. According to the social constructionism theory that guides this study, societal and interpersonal influences shape how people live their lives, as such, and subject selection by boys and girls is thus formed and informed across many settings and societies by cultural and social values.
Research on the Docking Strategy Between the Curriculum System of Tourism Management in Colleges and Universities and the Needs of the Industry
Authors: Jiang Rui , Zhang Xiaowei
Published: August 2024

This paper aims to explore effective strategies for aligning the curriculum of tourism management programs in universities with the demands of the industry, ensuring that educational content remains closely connected to the current practical needs of the tourism sector. By analyzing the current status of curriculum design in tourism management programs and combining it with the latest development trends and talent demands in the tourism industry, this study reveals the gaps and challenges between the curriculum and industry needs. The paper proposes a set of specific strategies for alignment, including optimizing curriculum design, strengthening practical teaching, and promoting university-industry collaboration, with the aim of enhancing the employability and industry adaptability of tourism management students. The results indicate that implementing these strategies can help better meet industry demands and promote the sustained development and quality improvement of tourism management education. Finally, this paper provides practical guidance and policy suggestions for the education reform of tourism management in colleges and universities.
Research on Digital Greening Management of Smart Gardens in Chenggong District, Kunming City
Authors: Sun Yifang , Gao Jia , Chen Chuanli
Published: August 2024

With the rapid urbanization in China, city scales have expanded, bringing numerous management challenges. The continuous expansion of urban green spaces highlights the difficulty of adapting traditional urban garden management to complex conditions. The solution lies in using AI and big data for smart city management, specifically termed 'Smart Gardens'. This system integrates modern information technology into daily urban garden management. Through platform management systems, it enables comprehensive planning, construction, maintenance, supervision, and service of urban green spaces. This ensures real-time data updates, visualized management, and dynamic services. This digital transformation is essential. This paper analyzes the current issues and future development strategies of digitalized garden management in Chenggong District, Kunming. Through literature review, field research, and data collection, it aims to enhance the green space management in Chenggong District and other regions.
Research on the Emergence and Development Trend of Software Defined Networks
Authors: Deng Wuxin , Guo Xiaodan
Published: August 2024

With the rise and development of computer networks, more and more network architecture systems have emerged, and software defined networks have also emerged. As a new type of network architecture system, it is used to achieve flexible control of network traffic and make the network a resource that can be flexibly allocated according to its own needs. For traditional networks, the architecture of traditional networks will encounter many problems, and the traditional network structure system is complex in hierarchy and has a large number of business volumes, making it difficult to cope with the development of future network systems and solve the problems of future network architecture. This article mainly introduces the emergence and development trends of software defined networks, as well as the help that software defined networks can bring to future network systems.
Research Progress of Chinese Medicine in the Treatment of Cardiac Arrhythmia
Authors: Lu Yajun , Zhu Ximei , Zhang Meng , Chen Jinfeng
Published: August 2024

With the increasing pressure of modern work and life, the irregularity of people's diet and rest has led to a younger incidence of arrhythmia. Although western drugs have obvious transient effects on the treatment of arrhythmias, long-term use of western drugs may produce a series of adverse effects, especially for patients with weak constitution. Therefore, most patients prefer Chinese medicine, which has fewer adverse reactions, is more effective and can regulate the functions of the whole system. In recent years, TCM has achieved remarkable results in the treatment of cardiac arrhythmias through accurate TCM diagnosis and treatment. This article focuses on the progress of TCM in the treatment of cardiac arrhythmias, with the aim of providing a reference for subsequent studies.
Theoretical Study and Clinical Application of Zhenwu Tang
Authors: Li Xueli , Lei Genping , Qu Yuan , Fu Huijie
Published: August 2024

In order to increase the use of Zhenwu Tang in the treatment of the disease, this paper examines Zhenwu Tang as the research object, specifically from its historical source, the experience of well-known experts, and its application in chronic kidney disease. It does this by analyzing theoretical, clinical, and experimental research on Zhenwu Tang in chronic kidney disease.
Research Progress of Diabetic Kidney Disease with Traditional Chinese Medicine
Authors: Tang Liangbi , Wang Huiling
Published: August 2024

Diabetic kidney disease is not only a common microvascular complication of diabetes, but also diabetes-specific renal damage. With the progress of the disease, it gradually develops into end-stage renal disease (ESRD). DKD showed podocyte loss, glomerular hypertrophy, Mesangial matrix dilation and glomerular basement membrane thickening in the early stage, and nodular glomerulosclerosis, Mesangial vasolysis, inflammation and interstitial fibrosis in the late stage [1-2]. at present, there is no specific treatment plan in western medicine. Clinical practice shows that traditional Chinese medicine has a significant and definite effect on delaying the progression of diabetic renal diseases. This article will summarize from three aspects: etiology and pathogenesis, syndrome differentiation and treatment.
Research Progress in the Treatment of Obese Polycystic Ovary Syndrome with Traditional Chinese Medicine
Authors: Wang Yu , Su Hongxia
Published: August 2024

Polycystic ovary syndrome (PCOS) is a common endocrine disorder in gynecology, with a high clinical incidence, which seriously affects the quality of life of adolescent and reproductive age women. This article expounds the progress of traditional Chinese medicine treatment of obese polycystic ovary syndrome, considers phlegm dampness as its primary pathogenic factor, and takes tonifying kidney, invigorating spleen and soothing liver as the basic treatment principles, in order to provide reliable and effective reference for traditional Chinese medicine treatment of PCOS.
Progress in the Study of Renal Injury Caused by a Novel Coronavirus
Authors: Lu Xian , Lei Genping , Yang Dong , Bai Jingxue
Published: August 2024

Novel Corona Virus Pneumonia (Corona Virus Disease 2019, COVID-19) in December 2019 became an epidemic disease. Chronic kidney disease (CKD) patients are highly sensitive to COVID-19, in-depth study and understanding of the mechanism of action and prevention and treatment strategies of CKD patients infected with novel coronavirus appears to be crucial. This article explored the selected topic by combing the relevant literature, and summarized the susceptibility to COVID-19 and the mechanism of renal involvement in CKD patients; the article shows that COVID-19 mainly enters the cells with ACE2 as the receptor to damage the kidneys directly, but also through cytokine storm, endothelial damage, immune dysregulation and other indirect ways of renal damage.
Professor PEI Ruixia’s Experience of Harmonizing in the Treatment of Diabetes Mellitus and Its Complications
Authors: Wu Qiong , Pei Ruixia
Published: August 2024

Diabetes mellitus and its complications, as one of the current challenges in clinical treatment, treated by traditional Chinese medicine with the advantages of individualization and targeting. This paper elaborates on Prof. Pei Ruixia's experience in analyzing the etiology and treatment of diabetes mellitus and its complications based on theories of traditional Chinese medicine (TCM). Prof. Pei believes that abnormal liver function is the core cause of diabetes and its complications. The " Harmonizing " is advocated throughout the treatment. The overall treatment is based on the basic idea of "reconciling Shaoyang and harmonizing yin and yang", with calm medication and a comprehensive approach.
Research Progress of Chinese Medicine in the Treatment of Acute Myocardial Infarction
Authors: Zhang Dong , Fan Yulin , Zhao Jing , Bao Aruhan , Zhao Jian
Published: August 2024

With the aging of the global population and changes in lifestyle, cardiovascular diseases, especially acute myocardial infarction (AMI), have become one of the major diseases threatening human health. Traditional Chinese medicine (TCM) has been practiced for thousands of years and has accumulated rich theories and methods for the treatment of acute myocardial infarction (AMI). Traditional Chinese medicine has unique advantages in the treatment of acute myocardial infarction and has made some progress in recent years. Modern medical research has also paid increasing attention to the mechanism of action and clinical application of TCM in the treatment of AMI. This article focuses on the unique advantages of TCM in the treatment of AMI from the perspective of integrating Chinese and Western medicine, and systematically reviews the research progress of TCM in the treatment of AMI through extensive literature combing.
Construction of Innovative Talent Cultivation Mode of "Three-Full Education" in Colleges and Universities from the"Grand Ideological and Political Course": Taking Universities in Shaanxi Province as an Example
Authors: Huang Yujing
Published: August 2024

Cultivating innovative talents is an important way to implement the strategy of rejuvenating the country through science and education and enhance the country's technological competitiveness. It is also a crucial measure for the education cause of socialism with Chinese characteristics to cultivate talents. Amidst the fierce confrontation of various social thoughts, it is the crucial responsibility and development mission of China's higher education to cultivate successors with unwavering socialist ideals and beliefs, as well as a pioneering and innovative spirit. Based on this, this paper mainly analyzes the "Three-Full Education" model in colleges and universities from the perspective of the"Grand Ideological and Political Course", discusses the development of innovative talent cultivation, and hopes to serve as a reference.