bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Effectiveness of the Online Platform in Tertiary Education in a Malaysian University
Authors: Ng Yim San , Chan Hai Lin
Published: November 2022

In many facets of our lives, the internet has become indispensable. The internet's role in transforming education has significantly altered both teaching and learning. The ability to learn online has been made feasible by the internet. Nguyen (2015) asserted that this had piqued the curiosity of many researchers and educators who want to use it to strengthen and advance student learning. This small-scale quantitative study examined how well employing online learning works in tertiary education at a Malaysian university. A total of 20 undergraduates from various faculties took part in an online survey. The survey covered both the benefits and drawbacks of online learning. 75% of the undergraduates agreed that using online resources allowed them to take control of their own learning. The results also reveal that, despite having the opportunity to learn conveniently and flexibly through the online platform, undergraduates still consider face-to-face classes a better approach to pursuing their degrees. Using the research findings as a guide, the researchers recommend that instructors using online learning take into account the relevance of the content and solutions, student support, and interaction between students and teachers for effective learning.
¿POR QUÉ EL ÉXITO PERSONAL NO ABARCA SOLO EL ASPECTO ECONÓMICO?: UN BREVE COMENTARIO
Authors: Ramos Serrano Rúsbel Freddy , Melchor Acevedo Braulio , Arias Sánchez Raúl Eleazar
Published: November 2022

El presente artículo es una breve reflexión sobre el éxito personal y su relación con el escenario económico. De igual forma, el presente trabajo es un acercamiento para iniciar un diálogo necesario sobre algunos condicionantes o determinantes del tema. Finalmente, se espera que la contribución del presente se pueda manifestar en un debate fructífero.
ОХУ-ын Алс дорнод, Дорнод сибирийн бүс нутгийн түлш эрчим хүчний салбарын өнөөгийн байдал
Authors: Ж Орхон
Published: November 2022

English title: Russian Federations Far East, East Siberia’s regions energy sector condition
Хоёр хөрш ба Монголын эдийн засгийн аюулгүй байдлын асуудлууд
Authors: Л Оюунгэрэл
Published: November 2022

English title: Two neighbours and the problems of the national security of Mongolia
Монгол Улс, Холбооны Бүгд Найрамдах Герман Улсын харилцаа, хамтын ажиллагааны хөгжил дэх Европын Холбооны хүчин зүйл
Authors: Р Жамц
Published: November 2022

English title: EU's factor in the relationships between Mongolia and Federal Republic of Germany
Хан үндэстний “гурав ба нэг” тэнгэрийн үзлийн тухайд
Authors: Ким Жо Хо
Published: November 2022

English title: On “three and one” celestial concept of Korea nation
Ойрх дорнодыг эзэгнэж явсан ойрад монгол султаанаа бид хэр мэддэг билээ?
Authors: Б Баасансүрэн
Published: November 2022

English title: How well do we know the Oirad Mongol Sultan who had took over Near East
Основания современной монгольской государственности
Authors: О Батсайхан , С.Л Кузьмин
Published: November 2022

English title: The establishment of modern Mongolian state
Хятадын шинэчлэлийг судлах арга зүйн асуудалд
Authors: Н Ариунгуа
Published: November 2022

English title: About the research method for Chinese reform
Чингис хаан ба Монголын нууц товчоо
Authors: Л Оюунгэрэл
Published: November 2022

English title: Chinggis khan and the Secret History of the Mongols
Канад, Америкийн харилцаа, чиг хандлага
Authors: Д Өэлүн-Үжин
Published: November 2022

English title: Tendency of the USA, Canadian relation
Глобалчлал хийгээд Монгол Улсын эдийн засгийн гадаад харилцааны асуудлыг хөндөж бичсэн нэгэн шинэ бүтээлийн тухай
Authors: Ц Гүрбадам
Published: November 2022

English title: About a book on Globalization and Foreign economic cooperation of Mongolia
Монгол Улс дахь Орос, Хятадын хөрөнгө оруулалтын тухай
Authors: Б Ганзориг , Д Начин
Published: November 2022

English title: The investments of Russia and China into Mongolia
Энергетический вектор сотрудничества в Северо-Восточной Азии
Authors: Г.С Яскина
Published: November 2022

English title: Energy cooperation in the North-East Asia
Монгол Улс, Европын Холбооны харилцаа, хамтын ажиллагаа: өнөөгийн түвшин ба ирээдүй
Authors: Л Оюунгэрэл
Published: November 2022

English title: Cooperation between Mongolia and European Union: current level and future
Хятадын баруун бүс нутгийн хөгжлийг түргэтгэх стратегийн хэрэгжилт
Authors: Хаварцэцэг
Published: November 2022

English title: Results of the strategy accelerating the development of western regions of China
Н.Е.Единархова “Монгол дахь оросууд” (русские в монголии) номын тухай
Authors: О Батсайхан
Published: November 2022

English title: About the book of N.E.Edinarkhova - “Russians in Mongolia”
Монгол дахь Зүүн Өмнөд Ази судлалын тойм
Authors: С Дашцэвэл
Published: November 2022

English title: Review of South East Asian studies in Mongolia
Глобалчлалын эриний Оросын эдийн засаг
Authors: Ц Баатар
Published: November 2022

English title: Russian economy in globalization century
Монгол Улс ба ОХУ-ын хил орчим, бүс нутаг, субъектүүдийн хамтын ажиллагааны шинэ чиг хандлага
Authors: С Дамдинсүрэн
Published: November 2022

English title: New tendencies in the cooperation between frontier zones, regions and subjects of Mongolia and Russian Federation
Analisa Produk Tabungan BSI dalam Menarik Minat Nasabah
Authors: Nor Firman Rachmad , Ilfiah Siti
Published: November 2022

Bank Syariah Indonesia Pasuruan Branch is one of the banks operating based on sharia principles that offers products for raising funds and distributing funds, one of which is BSI savings. This BSI savings account is based on sharia principles with a mudharabah muthlaqah contract. This study uses primary data and secondary data. The results showed that the marketing strategy of BSI's savings products was to attract customers' interest. Bank Syariah Indonesia Pasuruan Branch has been running well, from promoting, socializing, distributing brochures and participating in certain events. In addition, the existence of Bank Syariah Indonesia Pasuruan Branch is very helpful for customers to open various kinds of savings provided by Bank Syariah Indonesia Pasuruan Sub-Branch Office.
BEĞENDIĞINIZ GIBI SHAKESPEARE’IN KOMEDI SANATI
Authors: MOHAMMADİ Ali
Published: November 2022

Shakespeare diğer oyun yazarlarından birçok yönden farklıdır; en belirginleri trajik, komik karakterler ve durumlar yaratmanın yanı sıra görünüşte benzer olmayan özellikleri bir araya getirmesidir. Örneğin, Shakespeare romantik evlilik mitini komedi biçimindeki diğer hicivcilerden daha fazla geliştirir. Onu bu kadar benzersiz yapan şey, alem yaparken ya da soytarılık yaparken karakterlerin zihinlerine ve kalplerine girmesidir. Shakespeare'in komedisi, onun gizli arzusunun yansımasıdır ve zamanının acı sosyal gerçeklerini seyirciye yansıtır. Ek olarak, Shakespeare'in zengin hayal gücü, gerçekten Evrensel olan bu başyapıtın yapı taşıdır. Genel olarak, komedileri sadece güldürmek ve okuyucuları eğlendirmek için değildir, her zaman insan düşüncesinin ufkunu genişleten ontolojik bir mesaj taşırlar. Onlar, insanın zorluklarını, varoluş felsefesini ve yaşamın geçici yönünü bulabileceğimiz çok işlevli bir tür ortamdır. Ne kadar muhafazakar olursa olsun, siyasi sistemlere çeşitli karakterler aracılığıyla meydan okuyarak alay eder. Shakespeare, komediyi asla kabul edilmiş bir alışılmış kavram biçiminde yaratmaz. Sanatının sırrı, hayata nasıl yaratıcı bir şekilde tepki verdiğinde yatar. Nitekim bu makale, Shakespeare'in komedi sanatını ve onun seleflerinden, özellikle de klasik hicivcilerden farklılıklarını tartışmaya yönelik bir girişimdir. Bu tartışma için seçilen oyun, süssüz sahneleri, pastoral edebiyat, aşk ve görünüm açısından çeşitli özellikler taşıyan Beğendiğiniz Gibidir.
Practical guidelines for therapeators for therapists to diagnose and to treat non -alcoholic fat liver disease
Authors: Балукова Екатерина Владимировна , Гулунов Заурбек Хазбиевич
Published: November 2022

Практические рекомендации предназначены для оптимизации тактики ведения пациентов с неалкогольной жировой болезнью печени и рекомендованы к использованию врачам, работающим в амбулаторном и стационарном звеньях здравоохранения Санкт-Петербурга, предназначены для врачей -терапевтов и всех специалистов, интересующихся вопросами клинической гастроэнтерологии. Настоящие практические рекомендации разработаны на основании утвержденных Клинических рекомендаций Минздрава России «Лекарственные поражения печени», утверждены Комитетом по здравоохранению Правительства Санкт-Петербурга 26 октября 2020 г.

Practical recommendations are intended to optimize the tactics of managing patients with non -alcoholic fatty liver disease and are recommended for use by physicians working in the outpatient and inpatient health sectors of St. Petersburg, are intended for general practitioners and all specialists interested in clinical gastroenterology. These practical recommendations were developed on the basis of the approved Clinical Recommendations of the Ministry of Health of Russia “Medicinal liver damage”, approved by the Health Committee of the Government of St. Petersburg on October, 26, 2020.
Entrenamiento del pensamiento creativo en el aprendizaje de una lengua extranjera
Authors: De la Morena Taboada Marian , Sánchez Burón Adolfo
Published: November 2022

En este artículo se revisan diferentesaspectos teóricos relacionados con lacreatividad y el aprendizaje de una lenguaextranjera. Se parte de una perspectivaintegradora de dos corrientes:por un lado, un enfoque basado en laadquisición de habilidades cognitivascomplejas, y por otro, un enfoque globaldel aprendizaje de la nueva lengua, enel que se plantea la necesidad de dirigirel proceso de enseñanza-aprendizajehacia la adquisición intuitiva de lasestructuras y vocabulario necesariospara el dominio del lenguaje. A continuaciónse muestran y analizan unaserie de actividades prácticas que puedenemplearse en el aula y que ejemplificanalgunos de los procedimientosimplicados en el procesamiento de lalengua extranjera al trabajar un procesocomo la creatividad.
Hacia un modelo teórico explicativo de burnout en deportista: una propuesta integradora /
Authors: Garcés de los Fayos Ruiz Enrique J , Vives Benedicto Laura
Published: November 2022

Cuestiones como su definición, la integración de las diferentes aportaciones conceptuales, y la elaboración del marco teórico para su comprensión han sido algunas de las cuestiones fundamentales que se han enmarcado dentro del estudio del burnout. Desde una exhaustiva conceptualización del síndrome de burnout en deportistas, en este artículo proponemos un modelo teórico explicativo del burnout en deportistas, basando el desarrollo del mismo en los diferentes aspectos complementarios que presentan los tres modelos teóricos ya existentes en esta población (Smith, 1986; Schmidt y Stein, 1991; y Coakley, 1992), así como aportando determinadas dimensiones que, desde nuestro punto de vista, se han obviado hasta el momento, tales como determinados factores de personalidad, que desde la investigación se han observado relevantes en el desarrollo de este síndrome. Finalizamos describiendo todos los aspectos contemplados en este modelo teórico que proponemos.
Motivación y estilos de pensamient: relaciones en el proceso de aprendizaje /
Authors: Fernández-Martín M.P. , Sánchez Burón Adolfo
Published: November 2022

El objetivo de esta investigación es comprobar la relación existente entre los estilos de pensamiento, legislativo, ejecutivo y judicial, y el tipo de motivación que despliegan los alumnos en su tarea de aprendizaje, entendida como sentimiento de autoeficacia, planificación y metas de ejecución o de aprendizaje. Estas variables explican directa e indirectamente cómo el alumno adquiere, procesa y soluciona problemas haciendo su aprendizaje eficaz y rentabilizando sus esfuerzos. Se trabajó con un total de 331 alumnos de primer curso de Educación Secundaria Obligatoria pertenecientes a cuatro colegios públicos de la zona sureste de Madrid. Se utilizó el cuestionario de Autoeficacia y Motivación Académica (Zimmerman, Bandura, y Martínez-Pons 1992), y el cuestionario de Estilos de Pensamiento (Grigorenko y Sternberg, 1997; Sternberg, 1990, 1999).Los resultados obtenidos confirmaron efectos favorables entre las variables motivacionales, concretamente, las metas de aprendizaje, y el estilo judicial.
Estrategias para regular la tristez: diferencias entre una muestra clínica y una muestra control en el inventario de afrontamiento de la depresión (CID) /
Authors: Hernangómez Criado Laura , Vázquez Valverde Carmelo
Published: November 2022

El objetivo de este estudio fue investigar las diferencias entre una muestra clínica y una muestra control en las estrategias de afrontamiento ante la tristeza mediante el empleo del Inventario de Afrontamiento de la Depresión (Coping Inventory of Depresión, CID). La muestra total fue constituida por 491 estudiantes y 57 pacientes con diagnósticos heterogéneos. En comparación con la muestra control, los pacientes manifestaron emplear menos estrategias de afrontamiento y percibir una menor eficacia de las mismas. Asimismo, la muestra clínica mostró un menor uso de la reevaluación cognitiva, y un mayor empleo de medicación y expertos, así como una mayor búsqueda de apoyo social y de expresión emocional ante determinados síntomas depresivos y más estrategias de supresión cognitiva (ignorar) frente a sentimientos de ira o enfado. Además, comer para afrontar la tristeza estaba asociado en los pacientes con la búsqueda cognitiva de soluciones mientras que el uso de alcohol y otras drogas se asociaba con la falta de expresión emocional. Se analizan las implicaciones de los resultados para la optimización de intervenciones psicoterapéuticas.
USAHA RENTAL MOBIL DITINJAU DARI EKONOMI ISLAM (STUDI KASUS ODE-ODE REVOLUSI RENTAL CAR KENDARI)
Authors: Lestari Devi , Nusantara Ambo Wonua , Nur Afiat Muhammad
Published: November 2022

The purpose of this study was to determine the application of car rental carried out by the Ode-Ode Revolution Car Rental Kendari in terms of Islamic Economics. The data analysis used in this research is inductive qualitative. The results of this study indicate that the lease has been running according to Islamic law, even leasing is prescribed in Islam. However, in the implementation of leasing at Ode-Ode Rental there is a deviation made by the tenant which we can see in the risk of accidents described previously, where the tenant cannot afford the damage to the car he experienced in accordance with the rental agreement. So that there is a deviation in the practice of renting in the Revolutionary Orders of Car Rental Kendari which is not in accordance with Islamic Economics, in Islamic Economics this practice is strictly prohibited because it has harmed other people, here we can see deviations that lead to a violation of the agreement that has been agreed upon. between the two parties between the business owner (leasing) and the tenant.
Insolvenzschutz für Betriebsrenten und Unionsrecht
Authors: Tangemann Lars
Published: November 2022

From the perspective of labor law, this paper addresses the question of what requirements the law of the European Union places on insolvency protection for occupational pensions and whether the national implementation law of Germany meets these requirements. Numerous implementation deficits are identified and the consequences of these deficits are evaluated. Particular focus is placed on determining the level of protection required by the law of the European Union for the insolvency protection of occupational pensions. In addition, the paper addresses relevant implementation deficits in the area of pension fund coverage, vesting periods, unregulated deferred compensation and the coverage exclusion for particularly high pensions.
Uzticamības paaugstināšanas metožu izstrāde automatizētām robotu ražotnēm
Authors: Bormanis Oskars
Published: November 2022

Promocijas darbā pētītas robotizētās ražošanas sistēmas, kuru centrā ir industriālais robots. Darba gaitā apskatītas industriālo robotu elektronikas izstrādes un ražošanas pārbaužu metodes, kā arī to loma aparatūras aprites ciklā. Būtiskākais darba sasniegums ir programmatūras rīka izstrāde robota programmēšanas valodas koda pārveidošanai par robota piedziņas invertora energoelektronikas komponentu kalpošanas laika patēriņu. Darbs iekļauj atšķirīgu industriālo robotu enerģijas apgādes veidu, kā arī to darbības režīmu uzticamības novērtējumu, kas veikts, izstrādāto rīku lietojot praksē.
An efficient and secure technique for image steganography using a hash function
Authors: Nezami Zahid Iqbal , Ali Hamid , Asif Muhammad , Aljuaid Hanan , Hamid Isma , Ali Zulfiqar
Published: November 2022

Steganography is a technique in which a person hides information in digital media. The message sent by this technique is so secret that other people cannot even imagine the information’s existence. This article entails developing a mechanism for communicating one-on-one with individuals by concealing information from the rest of the group. Based on their availability, digital images are the most suited components for use as transmitters when compared to other objects available on the internet. The proposed technique encrypts a message within an image. There are several steganographic techniques for hiding hidden information in photographs, some of which are more difficult than others, and each has its strengths and weaknesses. The encryption mechanism employed may have different requirements depending on the application. For example, certain applications may require complete invisibility of the key information, while others may require the concealment of a larger secret message. In this research, we proposed a technique that converts plain text to ciphertext and encodes it in a picture using up to the four least significant bit (LSB) based on a hash function. The LSBs of the image pixel values are used to substitute pieces of text. Human eyes cannot predict the variation between the initial Image and the resulting image since only the LSBs are modified. The proposed technique is compared with state-of-the-art techniques. The results reveal that the proposed technique outperforms the existing techniques concerning security and efficiency with adequate MSE and PSNR.
Synergistic action of expandable graphite on fire safety of a self‐intumescent flame retardant epoxy resin
Authors: Zhao Cheng‐Shou , Jiang Yi‐Song , Liu Zhuang‐Yuan , Peng Hua‐Qiao , Esmaeili Nima
Published: November 2022

Previously, it was reported that epoxy resin (EP) filled with ammonium polyphosphate (APP) and copper (I) oxide (Cu2O) at a mass ratio of 8/2 (APP8‐Cu2O2) as a self‐intumescent system demonstrated promising fire retardancy. To further improve the flame retardant efficiency, the possibility of expandable graphite (EG) as an effective synergist for the self‐intumescent EP system was revealed by limiting oxygen index (LOI) test. The results showed that the incorporation of EG increased the LOI value of EP/APP8‐Cu2O2 obviously. The highest LOI value was obtained at the EG/APP8‐Cu2O2 mass ratio of 3/7, indicating the optimal synergistic effect being achieved. Furthermore, UL‐94 test results showed that the excellent synergistic effect resulted in the addition of 13 wt% EG/APP8‐Cu2O2 of 3/7 not only endowed EP a relatively high LOI value of 34.3%, but also made it pass UL‐94 V‐0 rating. Moreover, the main fire hazard parameters obtained from cone calorimeter tests, such as peak heat release rate, total smoke production, and peak CO production were reduced 40.3%, 30.3%, and 46.2%, respectively by the combination effect of EG/APP8‐Cu2O2 with mass ratio of 3/7, suggesting the excellent improvement in the fire safety of EP significantly. Finally, a possible action mode, which would be beneficial for developing other flame retardant polymers with high fire safety, was proposed.
Forecasting the IoT‐based cyber threats using the hybrid forage dependent ensemble classifier
Authors: Turukmane Anil V.
Published: November 2022

The Internet of Things is considered to be an emerging trend since it facilitates more effective communication among smart devices. The IoT technology acts as a double‐edged sword that has multiple advantages, along with the advantages, the cyber threats in the network have increased proportionally which initiates the necessity for the manufacturers to provide in‐built security‐enabled physical devices. Therefore, for ensuring IoT security against cyber threats, this research proposed a novel innovative detection method relying on the hybridized ensemble classifier. The classifier is developed through the integration of the Hybrid Forage Optimization (HFO) with the ensembled classifier. The hybrid ensemble classifier is developed based on the hybridization of convolutional neural network (CNN) and long short‐term memory (LSTM) classifiers, which provides more efficiency. The proposed hybrid forage optimization is initiated by integrating the searching characteristics of the birds, and animals for their food, which aims at locating the optimal food source. Moreover, the add‐on advantage is regarding the ensemble classifier, which is empowered with CNN and LSTM networks that further boosts the classification performance. The analysis of the datasets, such as the NSL‐KDD and KDD Cup 1999 dataset reveals that the accuracy of the classifier is 96% and 94%., which outperforms the existing methods.
Evaluation of long‐term changes in precipitation over Bolivia based on observations and Coupled Model Intercomparison Project models
Authors: Vicente‐Serrano Sergio M. , Maillard Oswaldo , Peña‐Angulo Dhais , Domínguez‐Castro Fernando , Noguera Iván , Lorenzo‐Lacruz Jorge , Azorin‐Molina César , Juez Carmelo , Guijarro José Antonio , Halifa‐Marín Amar , El Kenawy Ahmed
Published: November 2022

Using observations and model simulations from the 5th and 6th phases of the Coupled Model Intercomparison Project (CMIP5 and CMIP6, respectively), this study evaluated changes in monthly, seasonal, and annual precipitation over Bolivia from 1950 to 2019. Results demonstrate that observed precipitation is characterized by strong interannual and decadal variability. However, long‐term precipitation trends were not identified on the annual scale. Similarly, changes in seasonal precipitation were almost nonsignificant (p > .05) for the study period. Spatially, albeit with its complex orography, no substantial regional variations in observed precipitation trends can be identified across Bolivia. In contrast, long‐term precipitation trends, based on CMIP5 and CMIP6 models, suggest a dominance of negative trends, mainly during austral winter (JJA) (−10%) and spring (SON) (−15%). These negative trends were more pronounced in the lowlands of Bolivia (−20%). Overall, these contradictory results highlight the need for validating precipitation trend outputs from model simulations, especially in areas of complex topography like Bolivia.
Diazotrophy modulates cyanobacteria stoichiometry through functional traits that determine bloom magnitude and toxin production
Authors: Wagner Nicole D. , Osburn Felicia S. , Taylor Raegyn B. , Back Jeffrey A. , Chambliss C. Kevin , Brooks Bryan W. , Scott J. Thad
Published: November 2022

Harmful cyanobacterial blooms are an increasing threat to water quality. The interactions between two ecophysiological functional traits of cyanobacteria, diazotrophy (nitrogen [N]‐fixation) and N‐rich cyanotoxin synthesis, have never been examined in a stoichiometric explicit manner. We explored how a gradient of resource N : phosphorus (P) affects the biomass, N, P stoichiometry, light‐harvesting pigments, and cylindrospermopsin production in a N‐fixing cyanobacterium, Aphanizomenon. Low N : P Aphanizomenon cultures produced the same biomass as populations grown in high N : P cultures. The biomass accumulation determined by carbon, indicated low N : P Aphanizomenon cultures did not have a N‐fixation growth trade‐off, in contrast to some other diazotrophs that maintain stoichiometric N homeostasis at the expense of growth. However, N‐fixing Aphanizomenon populations produced less particulate cylindrospermopsin and had undetectable dissolved cylindrospermopsin compared to non‐N‐fixing populations. The pattern of low to high cyanotoxin cell quotas across an N : P gradient in the diazotrophic cylindrospermopsin producer is similar to the cyanotoxin cell quota response in nondiazotrophic cyanobacteria. We suggest that diazotrophic cyanobacteria may be characterized into two broad functional groups, the N‐storage‐strategists and the growth‐strategists, which use N‐fixation differently and may determine patterns of bloom magnitude and toxin production in nature.
An improved adaptive hp mesh refinement method in solving optimal control problems
Authors: Luo Changxin , Li Jiong , Zhou Chijun , Lei Humin
Published: November 2022

In order to improve the efficiency of the adaptive hp pseudospectral method in solving the optimal control problems, an improved adaptive hp pseudospectral method is proposed in this paper. This method mainly improves the mesh refinement process of the traditional hp pseudospectral method to reduce the number of mesh iterations, so as to achieve the purpose of shortening the solving time. The focus of this method is twofold. Firstly, by judging the position of the sudden change points of control curve, the mesh is refined in advance around them. Secondly, the non‐uniform segmentation iteration is carried out by using the curvature of the system state curve as the criterion. These two points together improve the solving efficiency of the proposed method. Through the convergence analysis and simulation verification, it is shown that the proposed method can effectively solve the optimal control problem, and it is also proved that the proposed method has higher solving efficiency than the traditional adaptive hp pseudospectral method.
Metabolic network changes during skotomorphogenesis in Arabidopsis thaliana mutant (atdfb‐3)
Authors: Li Xingjuan , Meng Hongyan , Liu Liqing , Hong Cuiyun , Zhang Chunyi
Published: November 2022

The metabolic networks underlying skotomorphogenesis in seedlings remain relatively unknown. On the basis of our previous study on the folate metabolism in seedlings grown in darkness, the plastidial folylpolyglutamate synthetase gene (AtDFB) T‐DNA insertion Arabidopsis thaliana mutant (atdfb‐3) was examined. Under the nitrate‐sufficient condition, the mutant exhibited deficient folate metabolism and hypocotyl elongation, which affected skotomorphogenesis. Further analyses revealed changes to multiple intermediate metabolites related to carbon and nitrogen metabolism in the etiolated atdfb‐3 seedlings. Specifically, the sugar, polyol, and fatty acid contents decreased in the atdfb‐3 mutant under the nitrate‐sufficient condition, whereas the abundance of various organic acids and amino acids increased. In response to nitrate‐limited stress, multiple metabolites, including sugars, polyols, fatty acids, organic acids, and amino acids, accumulated more in the mutant than in the wild‐type control. The differences in the contents of multiple metabolites between the atdfb‐3 and wild‐type seedlings decreased following the addition of exogenous 5‐F‐THF under both nitrogen conditions. Additionally, the mutant accumulated high levels of one‐carbon metabolites, such as Cys, S‐adenosylmethionine, and S‐adenosylhomocysteine, under both nitrogen conditions. Thus, our data demonstrated that the perturbed folate metabolism in the atdfb‐3 seedlings, which was caused by the loss‐of‐function mutation to AtDFB, probably altered carbon and nitrogen metabolism, thereby modulating skotomorphogenesis. Furthermore, the study findings provide new evidence of the links among folate metabolism, metabolic networks, and skotomorphogenesis.
Learn–confirm in model‐informed drug development: Assessing an immunogenicity quantitative systems pharmacology platform
Authors: Franssen Linnea C. , Swat Maciej J. , Kierzek Andrzej M. , Rose Rachel H. , van der Graaf Piet H. , Grimm Hans Peter
Published: November 2022

Immunogenicity against therapeutic proteins frequently causes attrition owing to its potential impact on pharmacokinetics, pharmacodynamics, efficacy, and safety. Predicting immunogenicity is complex because of its multifactorial drivers, including compound properties, subject characteristics, and treatment parameters. To integrate these, the Immunogenicity Simulator was developed using published, predominantly late‐stage trial data from 15 therapeutic proteins. This single‐blinded evaluation with subject‐level data from 10 further monoclonals assesses the Immunogenicity Simulator's credibility for application during the drug development process.
Sample size re‐estimation in Phase 2 dose‐finding: Conditional power versus Bayesian predictive power
Authors: Liu Qingyang , Hu Guanyu , Ye Binqi , Wang Susan , Wu Yaoshi
Published: November 2022

Unblinded sample size re‐estimation (SSR) is often planned in a clinical trial when there is large uncertainty about the true treatment effect. For Proof‐of Concept (PoC) in a Phase II dose finding study, contrast test can be adopted to leverage information from all treatment groups. In this article, we propose two‐stage SSR designs using frequentist conditional power (CP) and Bayesian predictive power (PP) for both single and multiple contrast tests. The Bayesian SSR can be implemented under a wide range of prior settings to incorporate different prior knowledge. Taking the adaptivity into account, all type I errors of final analysis in this paper are rigorously protected. Simulation studies are carried out to demonstrate the advantages of unblinded SSR in multi‐arm trials.
Urinary liver‐type fatty acid‐binding protein in clinically healthy elderly cats: Evaluation of its potential to detect IRIS stage 1 chronic kidney disease and borderline proteinuria
Authors: Kongtasai Thirawut , Paepe Dominique , Mortier Femke , Marynissen Sofie , Meyer Evelyne , Duchateau Luc , Daminet Sylvie
Published: November 2022

Background

Urinary liver‐type fatty acid‐binding protein (uL‐FABP) is a promising biomarker to detect early chronic kidney disease (CKD) in cats. Few healthy cats show increased uL‐FABP for unknown reasons.

Objectives

The objective of this study was to evaluate uL‐FABP in a large healthy elderly cat population comparing cats with and without International Renal Interest Society (IRIS) stage 1 CKD and with and without borderline proteinuria.

Methods

This was a cross‐sectional study. One hundred ninety‐six clinically healthy client‐owned cats of ≥7 years old were subdivided based on two criteria: (1) having either IRIS stage 1 CKD or no evidence of CKD and (2) having borderline proteinuria or no proteinuria. Urinary L‐FABP was measured using a validated commercially available feline L‐FABP ELISA.

Results

Overall, uL‐FABP was detectable in 6/196 (3%) healthy elderly cats. For the first subdivision, nine (5%) cats had IRIS stage 1 CKD, 184 cats had no evidence CKD and three cats were excluded. All cats with IRIS stage 1 CKD had uL‐FABP concentrations below the detection limit, whereas 6/184 (3%) cats without IRIS stage 1 CKD had detectable uL‐FABP concentrations (median 1.79 ng/ml, range 0.79–3.66 ng/ml). For the second subdivision, 47 (24%) cats had borderline proteinuria, 147 cats had no proteinuria and two cats were excluded. One of the borderline proteinuric cats had a detectable uL‐FABP concentration, whereas the other five cats with detectable uL‐FABP concentrations were non‐proteinuric.

Conclusion

With the current assay, the screening potential of uL‐FABP as an early biomarker for feline CKD is limited as uL‐FABP was rarely detected in clinically healthy elderly cats independently of the presence of either IRIS stage 1 CKD or borderline proteinuria.
EPELI: a novel virtual reality task for the assessment of goal-directed behavior in real-life contexts
Authors: Seesjärvi Erik , Puhakka Jasmin , Aronen Eeva T. , Hering Alexandra , Zuber Sascha , Merzon Liya , Kliegel Matthias , Laine Matti , Salmi Juha
Published: November 2022

A recently developed virtual reality task, EPELI (Executive Performance in Everyday LIving), quantifies goal-directed behavior in naturalistic conditions. Participants navigate a virtual apartment, performing household chores given by a virtual character. EPELI aims to tap attention, executive function, and prospective memory. To ensure its applicability to further research and clinical work and to study its relationship to relevant background factors, we examined several key properties of EPELI in 77 typically developing 9–13-year-old children. These included EPELI’s internal consistency, age and gender differences, sensitivity to gaming experience, head-mounted display (HMD) type, and verbal recall ability, as well as its relationships with parent-rated everyday executive problems. Of the eight EPELI measures, the following six showed acceptable internal consistency: task and navigation efficacy, number of correctly performed tasks and overall actions, time monitoring, and controller movement. Some measures were associated with age, gender, or verbal encoding ability. Moreover, EPELI performance was associated with parent-rated everyday executive problems. There were no significant associations of gaming background, task familiarity, or HMD type with the EPELI measures. These results attest to the reliability and ecological validity of this new virtual reality tool for the assessment of attention, executive functions, and prospective memory in children.
A Density-Dependent Target Stimulus for Inverse Bone (Re)modeling with Homogenized Finite Element Models
Authors: Bachmann Sebastian , Pahr Dieter H. , Synek Alexander
Published: November 2022

Inverse bone (re)modeling (IBR) can infer physiological loading conditions from the bone microstructure. IBR scales unit loads, imposed on finite element (FE) models of a bone, such that the trabecular microstructure is homogeneously loaded and the difference to a target stimulus is minimized. Micro-FE (µFE) analyses are typically used to model the microstructure, but computationally more efficient, homogenized FE (hFE) models, where the microstructure is replaced by an equivalent continuum, could be used instead. However, also the target stimulus has to be translated from the tissue to the continuum level. In this study, a new continuum-level target stimulus relating relative bone density and strain energy density is proposed. It was applied using different types of hFE models to predict the physiological loading of 21 distal radii sections, which was subsequently compared to µFE-based IBR. The hFE models were able to correctly identify the dominant load direction and showed a high correlation of the predicted forces, but mean magnitude errors ranged from − 14.7 to 26.6% even for the best models. While µFE-based IBR can still be regarded as a gold standard, hFE-based IBR enables faster predictions, the usage of more sophisticated boundary conditions, and the usage of clinical images.
European Mail Armour
Authors: Wijnhoven Martijn A.
Published: November 2022

Mail armour (commonly mislabelled 'chainmail') was used for more than two millennia on the battlefield. After its invention in the Iron Age, mail rapidly spread all over Europe and beyond. The Roman army, keen on new military technology, soon adopted mail armour and used it successfully for centuries. Its history did not stop there and mail played a vital role in warfare during the Middle Ages up to the Early Modern Period.

Given its long history, one would think mail is a well-documented material, but that is not the case. For the first time, this books lays a solid foundation for the understanding of mail armour and its context through time. It applies a long-term multi-dimensional approach to extract a wealth of as yet untapped information from archaeological, iconographic and written sources. This is complemented with technical insights on the mail maker's chaîne opératoire.
TANTALVS POETA: THE CATALOGUE OF THE GREAT SINNERS IN SENECA'S THYESTES 1–13
Authors: Martorana Simona
Published: November 2022

The opening lines of Seneca's Thyestes (1–13), which feature Tantalus’ reference to the so-called great sinners, have received little critical attention. Through both an intertextual and an intratextual analysis, this article reveals the peculiarities of this allegedly canonical list of sinners by comparing it to similar catalogues in other Senecan dramas, as well as by identifying its structural function within this particular tragedy. This kind of two-fold approach enables a reinterpretation of certain key passages of the drama vis-à-vis lines 1–13, as well as a reassessment of Tantalus’ role as the creative force and architect of the tragedy.
NERO'S EXPERIMENTS WITH THE WATER-ORGAN
Authors: Morgan Harry
Published: November 2022

This article examines a pair of anecdotes in the works of Suetonius and Cassius Dio, describing Nero's passionate late-career interest in the instrument known as the hydraulis or water-organ. The first half of the article contextualizes the water-organ episode in light of both the history of the instrument's reputation and the wider characterization of Nero in the literary sources. The rest of the article uses the episode to shed light on Nero's self-representation as princeps, focussing on the significance of the water-organ as both a musical instrument and a technological marvel. On the one hand, the organ's popularity with Roman audiences of the Early Imperial period made it a politically strategic choice for a music-loving emperor with strong populist leanings. On the other hand, the association of the organ with the intellectual world of Hellenistic Alexandria appealed to a certain group of Roman elites (including Nero himself), who shared a keen interest in technological innovation and technical knowledge more broadly. In the end, however, Nero's experiments with the water-organ were cleverly trivialized by hostile writers and redeployed as an illustration of the emperor's most appalling vices.
More than a visitor? Rethinking metaphors for family care in long-term care homes
Authors: Klostermann Janna , Funk Laura
Published: November 2022

Recent public and policy interventions aim to recognise formally the contributions of family care-givers to long-term residential care in Canada, with some arguing family carers are more than visitors and should be recognised as essential care-givers. These developments call for reconsidering how family care roles are understood and operationalised. Drawing on ethnographic research conducted in three care homes in Ontario, Canada, we present an in-depth feminist rhetorical analysis of the narrated lives and work practices of 12 unpaid family carers. Specifically, we explore how unpaid family carers themselves draw on broader discursive ‘ruling metaphors’ to interpret their roles and activities (e.g. as essential care-givers, visitors, team members), and how these metaphors invoke, organise and/or give rise to particular practices, responsibilities and relations. We contrast the stories of a family member who positioned herself as an essential care-giver and expressed a more onerous sense of individual responsibility with the stories of people who enjoyed the pleasures of visiting, who contributed as team members in ways that went beyond caring for their own relatives' care needs, and who embraced the possibilities that came with volunteering and with being able to influence change. Our analysis situates and contextualises participants' stories of their involvement and unpaid work in relation to their everyday material conditions and circumstances. We elaborate how different ways of understanding caring roles shape the nature of carers' unpaid work, as well as their options to share responsibility or set limits on that work. We also raise questions about the organisational conditions needed to help enact care as a shared collective responsibility.
Optimal allocation of policy limits in layer reinsurance treaties
Authors: Wang Chuchu , Wang Wei , Zhang Yiying , Zhao Peng
Published: November 2022

Layer reinsurance treaty is a common form obtained in the problem of optimal reinsurance design. In this paper, we study allocations of policy limits in layer reinsurance treaties with dependent risks. We investigate the effects of orderings and heterogeneity among policy limits on the expected utility functions of the terminal wealth from the viewpoint of risk-averse insurers faced with right tail weakly stochastic arrangement increasing losses. Orderings on optimal allocations are presented for normal layer reinsurance contracts under certain conditions. Parallel studies are also conducted for randomized layer reinsurance contracts. As a special case, the worst allocations of policy limits are also identified when the exact dependence structure among the losses is unknown. Numerical examples are presented to shed light on the theoretical findings.
Learning to express causal events in Mandarin Chinese: A multimodal perspective
Authors: NIU Chenxi , CIENKI Alan , ORTEGA Gerardo , COENE Martine
Published: November 2022

Previous research has shown language-specific features play a guiding role in how children develop expression of events with speech and gestures. This study adopts a multimodal approach and examines Mandarin Chinese, a language that features context use and verb serializations. Forty children (four-to-seven years old) and ten adults were asked to describe fourteen video stimuli depicting different types of causal events involving location/state changes. Participants’ speech was segmented into clauses and co-occurring gestures were analyzed in relation to causation. The results show that the older the children, the greater the use of contextual clauses which contribute meaning to event descriptions. It is not until the age of six that children used adult-like structures – namely, using single gestures representing causing actions and aligning them with verb serializations in single clauses. We discuss the implications of these findings for the guiding role of language specificity in multimodal language development.
Extraterrestrial nature reserves (ETNRs)
Authors: Smith Paul L.
Published: November 2022

If human population growth is not controlled, natural areas must be sacrificed. An alternative is to create more habitat, terraforming Mars. However, this requires establishment of essential, ecosystem services on a planet currently unamenable to Terran species. Shorter term, assembling Terran-type ecosystems within contained environments is conceivable if mutually supportive species complements are determined. Accepting this, an assemblage of organisms that might form an early, forest environment is proposed, with rationale for its selection. A case is made for developing a contained facsimile, old growth forest on Mars, providing an oasis, proffering vital ecosystem functions (a forest bubble). It would serve as an extraterrestrial nature reserve (ETNR), psychological refuge and utilitarian botanic garden, supporting species of value to colonists for secondary metabolites (vitamins, flavours, perfumes, medicines, colours and mood enhancers). The design presented includes organisms that might tolerate local environmental variance and be assembled into a novel, bioregenerative forest ecosystem. This would differ from Earthly forests due to potential impact of local abiotic parameters on ecosystem functions, but it is argued that biotic support for space travel and colonization requires such developments. Consideration of the necessary species complement of an ETNR supports a view that it is not humanity alone that is reaching out to space, it is life, with all its diverse capabilities for colonization and establishment. Humans cannot, and will not, explore space alone because they did not evolve in isolation, being shaped over aeons by other species. Space will be travelled by a mutually supportive system of Terran organisms amongst which humans fit, exchanging metabolites and products of photosynthesis as they have always done.
Asymmetric Wigner molecules in nanowire Y-junctions
Authors: Méndez-Camacho R. , Cruz-Hernández E.
Published: November 2022

The possibility of crystalline states of interacting electrons, known as Wigner crystals, has been intensively studied in each of the three dimensions. One-dimensional (1D) systems, however, can be interconnected forming two-dimensional (2D) lattices, being a three-terminal Y-junction (Y-J) the simplest one. Then, even when electrons in the individual branches of the Y are confined in 1D, as the Y-J is in 2D, one could expect significant differences in the crystalline state of the electron gas in a Y-J. With the recent report of fabrication of defect-free GaAs/AlGaAs Y-Js by epitaxial methods, the study of semiconductor Y-Js acquires a special relevance due to its eventual direct exploration. Here, by considering the collective electron interactions using a Yukawa-like effective potential, we explore a two-electron distribution in nanowire Y-Js by modulating its electron density via a screening parameter. We find that the electrons changes from a quasi-continuous to a Wigner molecule-like distribution when the electron density decreases in the Y-J. In bold contrast to the strict 1D case, where equidistant distributions of equal density are obtained in the Wigner regime, in the Y-J equidistant distributions of asymmetric density are induced. We also explore the effect of an external electric field acting along the Y-axis on the asymmetric distributions.
Theoretical study on the mechanism of the hydrogen evolution reaction catalyzed by platinum subnanoclusters
Authors: Kuge Keita , Yamauchi Kosei , Sakai Ken
Published: November 2022

Various concerted proton–electron transfer pathways rationalizing fast electrocatalytic H2 evolution routes by small platinum clusters are demonstrated using DFT with an implication of their relevance to electrocatalysis over platinum electrodes.
SO2 capture enhancement due to confined methanol within MIL-53(Al)-TDC
Authors: Zárate J. Antonio , González-Zamora Eduardo , Ibarra Ilich A. , Díaz Gabriela
Published: November 2022

In comparison with fully activated MIL-53(Al)-TDC, MeOH@MIL-53(Al)-TDC shows a 39% higher SO2 capture capacity.
Multi-specific niflumic acid platinum(iv) complexes displaying potent antitumor activities by improving immunity and suppressing angiogenesis besides causing DNA damage
Authors: Li Linming , Zhang Ming , Jia Dianlong , Liu Zhifang , Zhang Ning , Sun Bin , Wang Zhengping , Liu Min , Wang Qingpeng
Published: November 2022

Niflumic acid platinum(iv) complexes exhibit effective antiproliferative and anti-metastatic activities by improving immunity, suppressing angiogenesis and causing serious DNA damage.
Self-healing nanocomposites via N-doped GO promoted “click chemistry”
Authors: Sanka R. V. Siva Prasanna , Rana Sravendra , Singh Poonam , Mishra Abhishek K. , Kumar Pankaj , Singh Manjeet , Sahoo Nanda Gopal , Binder Wolfgang H. , Yun Gun Jin , Park Chanwook
Published: November 2022

N-Doped graphene stabilized Cu(i)-catalyzed self-healing nanocomposites are developed, where N-doped graphene is helpful to enhance mechanical and conductive properties as well as catalyst promoter helpful to trigger self-healing via click chemistry.