bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic review of protective factors related to academic resilience in children and adolescents: unpacking the interplay of operationalization, data, and research method
Authors: Ye Wangqiong , Teig Nani , Blömeke Sigrid
Published: August 2024

Identifying protective factors that promote academic resilience is vital. Nevertheless, due to the variations in the operationalizations of academic resilience, timeframes, data sources, and employed research methods, it remains unclear whether the impact of protective factors identified across studies can be attributed to the factors themselves or to these variations. By addressing these uncertainties, this study aims to provide an overview of the protective factors that have been extensively investigated in academic resilience and their degree of influence. A literature search found 119 empirical studies on protective factors in education settings for children and adolescents. The review analyzed five protective factors groups (individual, family, school, peer, community), three operationalizations of academic resilience (simultaneous, progressive, instrumental), two timeframes (longitudinal, non-longitudinal), three data sources (self-collected, national/local assessments, international large-scale assessments), and commonly employed research methods. The studies analyzed in this review yielded mixed results regarding the impact of the examined protective factors, with measurement instruments and statistical power playing a significant role in explaining the variations. Individual and school-level characteristics emerged as the most well-studied protective factors; individual characteristics were often investigated through “instrumental” operationalization and structural equational models, whereas school-level characteristics were typically explored through “simultaneous” or “progressive” operationalizations and multilevel modeling. Approximately 31 and 16% of the studies utilized national assessments and international large-scale assessment data, respectively. Both data sources promoted the exploration of school-level factors, with the former facilitating the exploration of protective factors across time and the latter contributing to the investigation of teaching-related factors.
Indifferent minds, broken system: a critical examination of mental health care provision for Spain’s incarcerated population with serious mental illnesses
Authors: Calcedo-Barba Alfredo , Antón Basanta Joaquín , Paz Ruiz Silvia , Muro Alvarez Alvaro , Elizagárate Zabala Edorta , Estévez Closas Verónica , López López Angeles , Barrios Flores Luis Fernando
Published: August 2024

Background

Spain healthcare system is decentralized, with seventeen autonomous regions overseeing healthcare. However, penitentiary healthcare is managed nationally, except in Catalonia, the Basque Country, and Navarra. These variations impact mental health care provision for inmates with serious mental illness (SMI).

Objective

To delineate differences between regions in terms of mental health care provision for individuals with SMI, available resources, and the perspectives of healthcare professionals operating in the Spanish prison environment.

Methods

Employing an explanatory sequential mixed-method approach, the study conducted an extensive literature review, quantitative data collection through structured questionnaires, and qualitative data collection via focus groups and four in-depth interviews. Analysis involved calculating percentages and ratios for quantitative data and thematic analysis for qualitative data interpretation to comprehensively understand mental healthcare provision.

Results

In December 2021, about 4% of inmates in Spain had SMI. There are three distinct models of mental healthcare within the Spanish prison system. The traditional penitentiary model, representing 83% of the incarcerated population, operates independently under the General Secretariat of Penitentiary Institutions at a national level. This model relies on an average of 5.2 penitentiary General Practitioners (pGP) per 1,000 inmates for psychiatric and general healthcare. External psychiatrists are engaged for part-time psychiatric assessment. Acute psychiatric hospitalization occurs in general nursing modules within penitentiary centers or in Restricted Access Units (RAUs) in reference hospitals. Two penitentiary psychiatric hospitals provide care to unimputable SMI inmates from all over Spain. Innovative penitentiary models, constituting 17% of the prison population, integrate penitentiary healthcare within regional public health systems. The Basque Country features a Mental Health Unit with full-time care teams within the penitentiary center. Catalonia emphasizes community care, providing full-time dedicated psychiatric services within and outside prisons, ensuring continued care in the community. Both models prioritize personnel with specialized mental health training and compensation akin to non-prison healthcare settings.

Conclusions

Regional disparities in penitentiary mental healthcare models in Spain result in resource inequalities, impacting specialized care for inmates with SMI and opportunities for healthcare professionals. The models in the Basque Country and Catalonia offer valuable experiences for penitentiary healthcare.
Inhibition, transition, and surge: dynamic evolution of pediatric respiratory pathogen trends amid COVID-19 pandemic policy adjustments
Authors: Xu Xuena , Pan Zhenzhen , Dong Heting , Zhang Yizhu , Xu Lina , Wang Pengli , Wang Yufeng , Li Jiaoyang , Jiang Wujun , Hao Chuangli
Published: August 2024

Background

The implementation of a zero-COVID policy for 3 years in China during the COVID-19 pandemic significantly impacted a broad spectrum of acute respiratory tract infections (ARTIs). The epidemiological characteristics of ARTI pathogens in children following the cessation of the zero-COVID policy remain unclear.

Methods

Etiologically diagnostic data from 82,708 children with ARTIs at the Children’s Hospital of Soochow University during 2016–2023 were analyzed for 8 pathogens (human respiratory syncytial virus [HRSV], influenza A [FluA], FluB, human parainfluenza virus [HPIV], adenovirus [ADV], human rhinovirus [HRV], bocavirus [BoV], and mycoplasma pneumoniae [MP]). The changes in respiratory infections in Suzhou, China during the first year (2020, Phase I) and the second and third years of the pandemic (2021–2022, Phase II) and the first year after the end of zero-COVID policy (2023, Phase III) versus that in the pre-pandemic years (2016–2019) were compared.

Results

When compared with the average pre-pandemic levels, the pathogen-positive rate decreased by 19.27% in Phase I (OR: 0.70; 95% CI: 0.67–0.74), increased by 32.87% in Phase II (OR: 1.78; 95% CI: 1.72–1.84), and increased by 79.16% in Phase III (OR: 4.58; 95% CI: 4.37–4.79). In Phase I, the positive rates of HRSV, FluA, ADV, and MP decreased by 26.72, 58.97, 72.85, and 67.87%, respectively, and the positive rates of FluB, HPIV, HRV, and BoV increased by 86.84, 25, 32.37, and 16.94%, respectively. In Phase III, the positive rates of HRSV, FluA, FluB, HPIV, ADV, and HRV increased by 39.74, 1046.15, 118.42, 116.57, 131.13, and 146.40%, respectively, while the positive rate of BoV decreased by 56.12%. MP was inhibited during the epidemic, and MP showed a delayed outbreak after the ending of the zero-COVID policy. Compared with the average pre-pandemic levels, the MP-positive rate in Phase III increased by 116.7% (OR: 2.86; 95% CI: 2.74–2.99), with the highest increase in 0–1-year-old children.

Conclusion

The strict and large-scale implementation of the zero-COVID policy in the early stages of the COVID-19 pandemic was the main driving factor for the sharp reduction in the rate of children’s respiratory pathogenic infections. The termination of this policy can cause a resurgence or escalation of pathogenic infections.
Transnational adoptees in healthcare: barriers, resources, and needs
Authors: Strand Mattias , Hillerberg Natte
Published: August 2024

Background

After decades of research output, it is well established that transnational adoptees—i.e., individuals who are placed for adoption outside their country of birth—exhibit an increased risk of various negative mental health outcomes. Even so, there is a lack of suggestions for preventive measures or treatment interventions targeting the transnational adoptee population in the literature.

Objective

To explore experiences, opinions, and needs among adult transnational adoptees in Sweden concerning healthcare in general and mental healthcare in particular.

Methods

Sixty-six adult transnational adoptees residing in Sweden, born in 15 different non-European countries, were recruited for individual in-depth interviews about their experiences and opinions regarding psychosocial support and healthcare. The interview data were analyzed employing a codebook thematic analysis approach.

Results

Three overarching themes were identified: (a) barriers to adequate treatment, (b) helpful resources in dealing with health-related issues, and (c) health-related needs and suggestions for the development of adequate support. Identified barriers include a lack of insight into and interest in adoptee health, colorblindness and unwillingness to address racism, expectations of gratitude, steep financial costs, lack of support from adoptive parents, and mistrust of support structures that involve adoptive parents or adoption organizations. Participants also describe helpful resources, such as the community of fellow transnational adoptees. Health-related needs and suggestions include more well-defined and easily accessible structures of support, improved knowledge and competence, a broader psychotherapeutic repertoire that better addresses adoption-related themes, improved support in situations that can be particularly stressful for adoptees (such as during pregnancy and as new parents), routine follow-up during childhood and adolescence, and education targeting adoptive parents. The need for greater attention to the well-being of children of transnational adoptees is also highlighted.

Implications

Based on these findings, a number of recommendations can be made. For example, knowledge about adoptee health should be strengthened, and psychotherapeutic competence in addressing issues related to racism should become a priority. After over 20 years of discussion, one or more national research and knowledge hubs on transnational adoption should be created. Moreover, economic resources should be made available to support transnational adoptees in accessing adequate treatment.
Social disconnection correlates of a “Wish to Die” among a large community-dwelling cohort of older adults
Authors: Ward Mark , Briggs Robert , Kenny Rose Anne
Published: August 2024

Introduction

Social disconnection and deaths by suicide among older adults are both important public health concerns, particularly in the context of ageing populations. The association between death ideation and behaviours, and social disconnection is well established and both functional and structural social relationships have been identified as predictive of suicide-related thoughts and behaviours. The “Wish to Die” (WTD) involves thoughts of or wishes for one’s own death or that one would be better off dead is a commonly used indicator to capture death ideation. It has been shown to be as predictive as active ideation of future suicide attempt.

Methods

Data were from a large cohort of community-dwelling older adults aged 50+, The Irish Longitudinal Study on Ageing (TILDA). Cross-sectional analyses of the association between numerous markers of social disconnection (loneliness, social isolation, living alone, marital status, social participation, volunteering, and attending religious service) and WTD were conducted.

Results

Multiple markers of social disconnection were associated with a “wish to die”. However, loneliness was the strongest risk factor while attendance of religious services was an important protective behaviour.

Discussion

There is a strong association between social disconnection and a WTD among older adults. There is also a strong association between depression and a WTD, while attending religious services or similarly prosocial settings may protect older adults from experiencing negative thoughts about dying.
SonoBox: development of a robotic ultrasound tomograph for the ultrasound diagnosis of paediatric forearm fractures
Authors: Ernst Floris , Osburg Jonas , Tüshaus Ludger
Published: August 2024

Introduction

Paediatric forearm fractures are a prevalent reason for medical consultation, often requiring diagnostic X-rays that present a risk due to ionising radiation, especially concerning given the sensitivity of children’s tissues. This paper explores the efficacy of ultrasound imaging, particularly through the development of the SonoBox system, as a safer, non-ionising alternative. With emerging evidence supporting ultrasound as a viable method for fracture assessment, innovations like SonoBox will become increasingly important.

Materials and methods

In our project, we want to advance ultrasound-based, contact-free, and automated cross-sectional imaging for diagnosing paediatric forearm fractures. To this end, we are building a technical platform that navigates a commercially available ultrasound probe around the extremity within a water-filled tank, utilising intelligent robot control and image processing methods to generate a comprehensive ultrasound tomogram. Safety and hygiene considerations, gender and diversity relevance, and the potential reduction of radiation exposure and examination pain are pivotal aspects of this endeavour.

Results

Preliminary experiments have demonstrated the feasibility of rapidly generating ultrasound tomographies in a water bath, overcoming challenges such as water turbulence during probe movement. The SonoBox prototype has shown promising results in transmitting position data for ultrasound imaging, indicating potential for autonomous, accurate, and potentially painless fracture diagnosis. The project outlines further goals, including the construction of prototypes, validation through patient studies, and development of a hygiene concept for clinical application.

Conclusion

The SonoBox project represents a significant step forward in paediatric fracture diagnostics, offering a safer, more comfortable alternative to traditional X-ray imaging. By automating the imaging process and removing the need for direct contact, SonoBox has the potential to improve clinical efficiency, reduce patient discomfort, and broaden the scope of ultrasound applications. Further research and development will focus on validating its effectiveness in clinical settings and exploring its utility in other medical and veterinary applications.
Overlapping cusp ion dispersions formed by flux ropes on the day-side magnetopause
Authors: Burkholder Brandon L. , Girma Yohannes , Porter Azzan , Chen Li-Jen , Dorelli John , Ma Xuanye , Da Silva Daniel , Connor Hyunju , Petrinec Steve
Published: August 2024

Introduction

Cusp ion dispersion signatures reflect properties of remote magnetic reconnection. Since the cusp is easier to observe in situ compared to the reconnection x-line, ion dispersions provide key insight on whether reconnection is variable in space and time. This study is motivated by a specific dispersion signature having two ion populations separated in energy but not space. These are known as overlapping dispersions because when observed by low-Earth orbiting satellites traversing the cusp, they appear as two dispersed ion populations overlapping in magnetic latitudes. Overlapping dispersion signatures have been observed for all interplanetary magnetic field (IMF) orientations and have been associated with multiple reconnection processes, but the three-dimensional magnetic reconnection topology and particle trajectories have not been examined.

Methods

Forward particle tracing using the GAMERA-CHIMP global magnetohydrodynamic (MHD) with test particle framework is carried out to construct ion dispersion signatures throughout the cusp. Under idealized solar wind driving with steady purely southward IMF, both standard and overlapping dispersions are found.

Results

Analysis of the test particle trajectories shows that the higher energy population of the overlapping dispersion travels along the axis of a flux rope before heading into the cusp, whereas the lower energy population goes directly into the cusp. Furthermore, the overlapping dispersions observed by the synthetic satellites compare well to Defense Meteorological Satellite Program (DMSP) F16 observations during strongly southward IMF.

Discussion

It is thus concluded that during strongly southward IMF, cusp-entering particles interacting with a magnetopause flux rope (generated by secondary reconnection) is one way to produce an overlapping dispersion. This study lays the groundwork for the forthcoming NASA Tandem Reconnection and Cusp Electrodynamics Reconnaissance Satellites (TRACERS) mission, which will connect the cusp to the magnetosphere—discovering how spatial or temporal variations in magnetic reconnection drive cusp dynamics. The expected launch of TRACERS is in 2025.
Performing performance: young aspiring athletes’ presentation of athletic identity
Authors: Skilbred Anette , Strandbu Åse , Loland Sigmund
Published: August 2024

Youths are in the process of figuring out answers to the question “who am I?” and young athletes are searching for athletic identity in interaction with their friends, teammates, coaches, and so on. This study explores athletes' presentations of athletic identity based on 24 interviews with ambitious young athletes attending upper secondary sport schools. Anchored in Goffman's theory of the self and the presentation of the self, as well as Markus and Nurius' concept of possible selves, the study views identity as socially constructed in interaction. Utilising this theoretical perspective alongside thematic analysis resulted in four themes that reveal characteristics that are deemed central in an athletic identity. First, the theme I am a dutiful athlete constitutes integral facets of the athletes' self-presentation as committed and diligent individuals. The interviews also bring to light variations in the athletes' attitudes and approaches towards these expectations and concepts. The remaining three themes: I must be unique, We must be unique, and I must have fun, illustrate how being a performing athlete extends beyond duties tied to training, resting, and eating. While the findings suggest the existence of certain dominant and desirable characteristics in an athletic identity, they also highlight variations in identities, emphasising negotiation and flexibility in handling the athlete role.
Investigating the role of women producers in alternative food networks implementing organic farming in Berlin Brandenburg
Authors: Darkhani Faiza
Published: August 2024

Introduction

This study sheds light on the challenges faced by women in alternative food networks (AFNs) applying organic farming in Berlin Brandenburg. They engage in AFNs as producers, consumers, and prosumers (producer-consumers). Literature indicates that individuals in farming face obstacles such as limited ownership, traditional gender roles, undervalued contributions, disparities in recognition and compensation, and barriers to leadership. The objective of this research is to understand the realities, self-perceptions, and conditions experienced by individuals in AFNs and organic farming. This study examines contextual factors, participation levels, decision-making processes, leadership dynamics, and impacts related to these participants.

Method

Using qualitative content analysis, interviews were conducted with active female respondents in three types of AFN: community-supported agriculture (CSA), food cooperatives (FCs), and self-harvest gardens (SHG).

Results

The interviewees expressed optimism about their involvement but emphasized the need for increased governmental support and community engagement. Participants in CSAs and FCs reported stronger producer-consumer connections and community building, while self-harvest gardeners sought personal growth and access to garden spaces.

Conclusion

Interview data highlighted demands for gender equality improvements and support mechanisms. Addressing these challenges and promoting equal status for them can enhance their contributions to community building and localized food production. Recognizing their efforts fosters societal inclusiveness and progress. Understanding and supporting individuals in organic farming AFNs, we can move towards a future where their contributions are properly acknowledged.
The sustainability of grain production: the impact of agricultural productive services on farmers’ grain profits
Authors: Han Guoying , Cui Wenchao , Chen Xiaoxuan , Gao Qiang
Published: August 2024

Increasing farmers’ grain profits is crucial for enhancing the sustainability of grain production and ensuring food security. As a widely applied agricultural management means at present, agricultural productive services are of great significance to study whether they can help increase farmers’ grain profits. This paper uses the micro-farmer data from the 2020 China Rural Revitalization Survey (CRRS). It employs an endogenous switching regression model and causal mediation analysis methods, which can address endogenous issues, to examine the impact of agricultural productive services on farmers’ grain profits and their underlying mechanisms. The results show: (1) Agricultural productive services significantly increase farmers’ grain profits and this conclusion is still robust after the robustness test. (2) The mechanism analysis indicates that agricultural productive services increase farmers’ grain profits through three pathways: yield enhancement, cost reduction, and efficiency improvement. (3) The heterogeneity analysis shows that agricultural productive services have a greater impact on increasing grain profits for farmers with lower grain profits, smaller operating scales, and lower degrees of farmland fragmentation. Our findings suggest that increasing support for agricultural productive services, fully leveraging the radiative driving role of service providers, and offering farmers various forms of productive services will be key measures to enhance farmers’ grain profits, promote sustainable grain production, and ensure food security.
Fluorescent enhanced endogenous carbon dots derived from green tea residue for multiplex detection of heavy metal ions in food
Authors: Zhang Lei , Cai Zhenli , Liu Yaqi , Fan Yao , She Yuanbin
Published: August 2024

Introduction

The presence of excessive heavy metal content in food poses potential risks to human health.

Methods

This paper presents the fabrication of a novel type of Carbon Dots (CDs) using green tea residue as a carbon source, which can be applied for simultaneous detection of Hg2+, Pb2+, Fe3+, and Cu22+ through particle swarm optimization (PSO) based optimized variable-weighted least-squares support vector machine (VWLS-SVM) model and the partial least squares discriminant analysis (PLSDA) method.

Results and Discussion

The utilization of PSO-VWLS-SVM model discovered and verified two fluorescence enhancement markers of CDs, namely isoquercitrin and 5-methyl furfural in green tea residues. By employing PLSDA, simultaneous qualitative and quantitative determination of these four metal ions was achieved. These CDs are capable of detecting four types of metal ions at low concentrations even when there are high concentrations of other metal ions and amino acids. More importantly, the CDs were successfully applied for the detection of Hg2+, Pb2+, Fe3+, and Cu2+ in real food samples. The recovery rates of four metal ions spiked into five different matrices were found to be the range of 99.1–101.3%, while both intra-day and inter-day relative standard deviations remained below 0.5% for all samples. This study on chemometrics-assisted exploration into formation mechanisms of endogenous CDs provides theoretical guidance for enhancing their fluorescence properties and expanding their application in heavy metal detection in food.
The French National Animal Health Surveillance Platform: an innovative, cross-sector collaboration to improve surveillance system efficiency in France and a tangible example of the One Health approach
Authors: Dupuy Céline , Locquet Célia , Brard Christophe , Dommergues Laure , Faure Eva , Gache Kristel , Lancelot Renaud , Mailles Alexandra , Marchand Justine , Payne Ariane , Touratier Anne , Valognes Aurèle , Carles Sophie
Published: August 2024

The French National Animal Health Surveillance Platform (NAHSP) was created in 2011. This network of animal health stakeholders was set up to improve surveillance efficiency for all health risks that threaten animal health, as well as zoonoses affecting human health. The NAHSP steering committee decides on the strategies and program of activities. It is composed of 11 institutions from both public and private sectors (policy-makers, scientific institutions, and representatives of farmers, veterinarians, hunters, and laboratories). A coordination team guarantees the implementation of the program and facilitates the activities of different working groups (WGs). Each WG is composed of technical experts with scientific, legal, and field knowledge from the sectors of animal health (livestock, companion animals, and wildlife), human health, and environmental health. Some WGs focus on a specific disease or health indicator, such as African swine fever or cattle mortality, while others cover cross-cutting topics, such as epidemic intelligence (EI), or specialize in aiding epidemiological investigations, such as the Q fever WG. The NAHSP stands out for its innovative approach because it is based on the concepts of consensus-building among participants, fostering collaboration, and embracing interdisciplinarity. Each proposal designed to improve surveillance is jointly developed by all the stakeholders involved, thereby ensuring its sustainability and acceptability among stakeholders. This process also has added value for decision-makers. As a pioneer platform, the NAHSP inspired the creation of two additional national surveillance platforms in 2018, one for plant health and the other for food chain safety. Both are organized in the same way as the NAHSP, which created a framework to place the emphasis on a One Health approach. For instance, four WGs are common to the three national surveillance platforms. This article aims to present this innovative approach to improve surveillance efficiency that could be of interest to other European countries or that could be rolled out at the European level.
Natural Product Auraptene Targets SLC7A11 for Degradation and Induces Hepatocellular Carcinoma Ferroptosis
Authors: Li Donglin , Li Yingping , Chen Liangjie , Gao Chengchang , Dai Bolei , Yu Wenjia , Yang Haoying , Pi Junxiang , Bian Xueli
Published: August 2024

The natural product auraptene can influence tumor cell proliferation and invasion, but its effect on hepatocellular carcinoma (HCC) cells is unknown. Here, we report that auraptene can exert anti-tumor effects in HCC cells via inhibition of cell proliferation and ferroptosis induction. Auraptene treatment induces total ROS and lipid ROS production in HCC cells to initiate ferroptosis. The cell death or cell growth inhibition of HCC cells induced by auraptene can be eliminated by the ROS scavenger NAC or GSH and ferroptosis inhibitor ferrostatin-1 or Deferoxamine Mesylate (DFO). Mechanistically, the key ferroptosis defense protein SLC7A11 is targeted for ubiquitin–proteasomal degradation by auraptene, resulting in ferroptosis of HCC cells. Importantly, low doses of auraptene can sensitize HCC cells to ferroptosis induced by RSL3 and cystine deprivation. These findings demonstrate a critical mechanism by which auraptene exhibits anti-HCC effects via ferroptosis induction and provides a possible therapeutic strategy for HCC by using auraptene or in combination with other ferroptosis inducers.
Phytochemical Composition Antioxidant and Anti-Inflammatory Activity of Artemisia dracunculus and Artemisia abrotanum
Authors: Țicolea Mădălina , Pop Raluca Maria , Pârvu Marcel , Usatiuc Lia-Oxana , Uifălean Ana , Ranga Floricuța , Pârvu Alina Elena
Published: August 2024

This study aimed to investigate the antioxidant and anti-inflammatory activities mechanism of Artemisia dracunculus (A. dracunculus) and Artemisia abrotanum (A. abrotanum) ethanol extracts in acute rat inflammation induced in Wistar male rats with turpentine oil. The characterization of the polyphenolic compounds in the extracts was conducted using UV–Vis and Fourier-transform infrared spectroscopy and high-performance liquid chromatography coupled with mass spectrometry techniques. The antioxidant activity of the extracts was evaluated in vitro by DPPH, FRAP, H2O2, and NO scavenging tests and in vivo by measuring the total oxidative status (TOS), total antioxidant capacity (TAC), oxidative stress index (OSI), 8-hydroxy-deoxyguanosine (8-Oxo-dG), advanced oxidation protein products (AOPP), malondialdehyde (MDA), nitric oxide (NO), 3-nitrotyrosine (3NT), and total thiols (SH). Inflammation was evaluated by measuring nuclear factor-kB-p65 (NfkB-p65) and NLRP3 inflammasome activation with IL-1β, IL-18, and gasdermin D. Liver and renal toxicity was determined following transaminases (ALT and AST), creatinine, and urea. The experimental results indicated that A. dracunculus and A. abrotanum ethanol extracts have moderate in vitro antioxidant activity and had in vivo antioxidant activity and an anti-inflammatory effect by NfkB-p65, IL-1b, IL-18, and gasdermin D serum level reduction. The antioxidant activity correlated with the chemical composition of the extracts. These results bring evidence-based use of A. dracunculus and A. abrotanum’s in traditional and contemporary medicine.
The Role of m6A Methylation in Tumor Immunity and Immune-Associated Disorder
Authors: Mu Siyu , Zhao Kaiyue , Zhong Shanshan , Wang Yanli
Published: August 2024

N6-methyladenosine (m6A) represents the most prevalent and significant internal modification in mRNA, with its critical role in gene expression regulation and cell fate determination increasingly recognized in recent research. The immune system, essential for defense against infections and maintaining internal stability through interactions with other bodily systems, is significantly influenced by m6A modification. This modification acts as a key post-transcriptional regulator of immune responses, though its effects on different immune cells vary across diseases. This review delineates the impact of m6A modification across major system-related cancers—including those of the respiratory, digestive, endocrine, nervous, urinary reproductive, musculoskeletal system malignancies, as well as acute myeloid leukemia and autoimmune diseases. We explore the pathogenic roles of m6A RNA modifications within the tumor immune microenvironment and the broader immune system, highlighting how RNA modification regulators interact with immune pathways during disease progression. Furthermore, we discuss how the expression patterns of these regulators can influence disease susceptibility to immunotherapy, facilitating the development of diagnostic and prognostic models and pioneering new therapeutic approaches. Overall, this review emphasizes the challenges and prospective directions of m6A-related immune regulation in various systemic diseases throughout the body.
Icaritin Exerts Anti-Cancer Effects through Modulating Pyroptosis and Immune Activities in Hepatocellular Carcinoma
Authors: Jiao Yuanyuan , Li Wenqian , Yang Wen , Wang Mingyu , Xing Yaling , Wang Shengqi
Published: August 2024

Icaritin (ICT), a natural compound extracted from the dried leaves of the genus Epimedium, possesses antitumor and immunomodulatory properties. However, the mechanisms through which ICT modulates pyroptosis and immune response in hepatocellular carcinoma (HCC) remain unclear. This study demonstrated that ICT exhibits pyroptosis-inducing and anti-hepatocarcinoma effects. Specifically, the caspase1-GSDMD and caspase3-GSDME pathways were found to be involved in ICT-triggered pyroptosis. Furthermore, ICT promoted pyroptosis in co-cultivation of HepG2 cells and macrophages, regulating the release of inflammatory cytokines and the transformation of macrophages into a proinflammatory phenotype. In the Hepa1-6+Luc liver cancer model, ICT treatment significantly increased the expression of cleaved-caspase1, cleaved-caspase3, and granzyme B, modulated cytokine secretion, and stimulated CD8+ T cell infiltration, resulting in a reduction in tumor growth. In conclusion, the findings in this research suggested that ICT may modulate cell pyroptosis in HCC and subsequently regulate the immune microenvironment of the tumor. These observations may expand the understanding of the pharmacological mechanism of ICT, as well as the therapy of liver cancer.
The Management of Necrotizing Gingivitis in Paediatric Patients: A Scoping Review and Two Case Reports
Authors: Ciribè Massimiliano , Cirillo Erika , Arduino Paolo Giacomo , Putrino Alessandra , Caputo Martina , Zaami Simona , Bompiani Gaia , Galeotti Angela
Published: August 2024

Necrotizing gingivitis (NG) is an acute inflammatory process with an estimated prevalence of less than 1%. The treatment of choice is usually antibiotics in addition to periodontal treatment. This scoping review aims to detail extent and type of proof related to NG in paediatric patient; moreover, a decision tree protocol was developed to define NG management in paediatric patients based on the presence or absence of systemic compromission. In addition, we also propose the use of ozone treatment as an adjuvant therapy. Seven papers (3 case reports, 2 guidelines, and 2 reviews) were selected for evaluation by reading the full texts. This review outlines the lack of research on the treatment of NG in paediatric patients; we, however, demonstrate the efficacy of the decision tree protocol by describing two case reports in which patients were treated with antibiotics according to the presence or absence of systemic involvement through the implementation of an individualized therapeutic approach, with periodontal ozone therapy. Moreover, the supportive use of this molecule in the management of NG can be a valuable tool in the healing of gingival tissues.
Socioeconomic Status and Rate of Poverty in Overweight and Obesity among Spanish Children and Adolescents
Authors: Gallego Alejandra , Olivares-Arancibia Jorge , Yáñez-Sepúlveda Rodrigo , Gutiérrez-Espinoza Héctor , López-Gil José Francisco
Published: August 2024

Background: This study aimed to analyze the relationship between socioeconomic status (SES), poverty rate, and the prevalence of overweight/obesity or obesity in children and adolescents aged 2–14. Methods: Parents or guardians reported the weight and height of participants, used to calculate body mass index (BMI) and BMI z-scores according to the International Obesity Task Force standards. Participants were categorized into “overweight/obesity” and “no overweight/obesity” and further into “obesity” and “no obesity”. The rate of poverty rate was determined using data from the National Statistics Institute of Spain, defining it as the percentage of people with income below 60% of the national median. SES was based on the head of household’s occupation and categorized into low, medium, and high levels. Results: Adjusted multilevel models showed participants with medium or high SES had lower odds of overweight/obesity compared to those with low SES (medium SES: odds ratio [OR]: 0.63, 95% confidence interval [CI]: 0.54–0.73; high SES: OR: 0.59, 95% CI: 0.49–0.70). Participants in the high-poverty group had higher odds of having overweight/obesity (OR: 1.40, 95% CI: 1.13–1.74) compared to the low-poverty group. Conclusions: The study highlights significant socioeconomic disparities in childhood overweight/obesity, emphasizing the potential impact of SES and poverty on health outcomes in Spanish children and adolescents.
Postoperative Recovery in the Youngest: Beyond Technology
Authors: Sjöberg Carina , Ringdal Mona , Jildenstål Pether
Published: August 2024

Background: Measuring and interpreting vital signs in pediatric patients recovering from anaesthesia, particularly those up to 36 months old, is challenging. Nurses’ decision-making regarding the level of monitoring must balance patient safety with individualized care. This study aimed to explore the perceptions of critical care nurses and registered nurse anesthetists regarding their experiences and actions when making decisions about vital sign monitoring for children in post-anesthesia care units (PACUs). Methods: A qualitative study utilizing the critical incident technique was conducted. Interviews were performed with a purposeful sample of 17 critical care nurses and registered nurse anaesthetists from two hospitals. Results: Nurses reported that the rationale for decisions concerning the need for vital sign monitoring in children was both adequate and inadequate. Actions were taken to adjust the monitoring of vital signs, optimizing conditions for assessment and ensuring the child’s safe recovery. Conclusions: The complexity of accurately monitoring children makes it challenging for nurses in the PACU to adhere to guidelines. Evidence-based care and safety are compromised when technology has limitations and is not adapted for paediatric use, leading to a greater reliance on experience and clinical assessment. This reliance on experience is crucial for reliable assessment but also entails accepting greater risks.
Perinatal Predictors and Mediators of Attachment Patterns in Preschool Children: Exploration of Children’s Contributions in Interactions with Mothers
Authors: Kurbatfinski Stefan , Woo Jennifer , Ntanda Henry , Giesbrecht Gerald , Letourneau Nicole
Published: August 2024

Insecure and disorganized attachment patterns in children are linked to poor health outcomes over the lifespan. Attachment patterns may be predicted by variables that influence the quality of children’s interactions with their primary caregivers/parents (usually mothers) such as prenatal and postnatal exposures and the children’s own behaviours in interactions. The purposes of this exploratory study were to examine: (1) prenatal predictors of children’s attachment patterns, and (2) postnatal mediators and moderators of associations between prenatal predictors and children’s attachment patterns, with adjustment for relevant covariates. Mother–child dyads (n = 214) from the longitudinal Alberta Pregnancy Outcomes and Nutrition (APrON) cohort were studied using valid and reliable measures. Hayes’ mediation analysis was employed to determine direct and indirect effects. Mothers’ prenatal cortisol levels directly predicted disorganized (versus organized) child attachment in unadjusted models. Children’s passivity (in adjusted models) and compulsivity (in unadjusted and adjusted models) in parent-child interactions mediated the pathway between mothers’ prenatal cortisol levels and children’s disorganized attachment patterns. Serial mediation analyses revealed that mothers’ cortisol levels predicted their children’s cortisol levels, which predicted children’s compulsivity, and, ultimately, disorganized attachment in both unadjusted and adjusted models. No predictors were correlated with children’s insecure (versus secure) attachment. This exploratory research suggests that prenatal exposure to mothers’ cortisol levels and children’s behavioural contributions to parent–child interaction quality should be considered in the genesis of children’s attachment patterns, especially disorganization. Interventions focused on parent-child interactions could also focus on addressing children’s behavioral contributions.
Assessment of Visual Attention in Teams with or without Dedicated Team Leaders: A Neonatal Simulation-Based Pilot Randomised Cross-Over Trial Utilising Low-Cost Eye-Tracking Technology
Authors: Kannan Loganathan Prakash , Garg Anip , McNicol Robert , Wall Conor , Pointon Matthew , McMeekin Peter , Godfrey Alan , Wagner Michael , Roehr Charles Christoph
Published: August 2024

Background: Eye-tracking technology could be used to study human factors during teamwork. Objectives: This work aimed to compare the visual attention (VA) of a team member acting as both a team leader and managing the airway, compared to a team member performing the focused task of managing the airway in the presence of a dedicated team leader. This work also aimed to report differences in team performance, behavioural skills, and workload between the two groups using validated tools. Methods: We conducted a simulation-based, pilot randomised controlled study. The participants included were volunteer paediatric trainees, nurse practitioners, and neonatal nurses. Three teams consisting of four team members were formed. Each team participated in two identical neonatal resuscitation simulation scenarios in a random order, once with and once without a team leader. Using a commercially available eye-tracking device, we analysed VA regarding attention to (1) a manikin, (2) a colleague, and (3) a monitor. Only the trainee who was the airway operator would wear eye-tracking glasses in both simulations. Results: In total, 6 simulation scenarios and 24 individual role allocations were analysed. Participants in a no-team-leader capacity had a greater number of total fixations on manikin and monitors, though this was not significant. There were no significant differences in team performance, behavioural skills, and individual workload. Physical demand was reported as significantly higher by participants in the group without a team leader. During debriefing, all the teams expressed their preference for having a dedicated team leader. Conclusion: In our pilot study using low-cost technology, we could not demonstrate the difference in VA with the presence of a team leader.
Obstructive Sleep Apnea Is Associated with Worsened Hospital Outcomes in Children Hospitalized with Asthma
Authors: Khatana Jasmine , Thavamani Aravind , Umapathi Krishna Kishore , Sankararaman Senthilkumar , Roy Aparna
Published: August 2024

Background: Studies have shown a bidirectional relationship between asthma and obstructive sleep apnea (OSA). However, there is a paucity of national-level data evaluating the impact of OSA on hospital outcomes in pediatric hospitalizations for asthma. Methods: We analyzed the National Inpatient Sample and Kids Inpatient Database to include all pediatric hospitalizations with a primary diagnosis of asthma between 2003–2016. Using ICD codes, the pediatric asthma cohort was divided into two groups: those with and those without a concomitant diagnosis of OSA. The primary outcomes were in-hospital mortality and the need for mechanical ventilation. The secondary outcomes were the lengths of each hospital stay and total hospitalization charges. Results: We analyzed 1,606,248 hospitalizations during the 14-year study period. The overall prevalence rate of OSA was 0.7%. Patients with asthma and OSA were significantly older (8.2 versus 5.9 years) and were more often male, p < 0.001. The OSA group had several increased comorbidities. The overall mortality rate was 0.03%, and multivariate regression analysis showed that OSA was associated with 4.3 times higher odds of in-hospital mortality (95% CI: 2.4 to 7.6, p < 0.001). Furthermore, OSA was associated with a 5.2 times greater need for mechanical ventilation (95% CI: 4.8 to 5.5, p < 0.001). Linear regression analyses demonstrated that OSA independently contributed an additional 0.82 days to the hospital stay length (95% CI: 0.79 to 0.86, p < 0.001) and an extra 10,479 USD (95% CI: 10,110 to 10,848, p < 0.001) in hospitalization charges. Conclusion: OSA in children admitted with asthma is associated with poor hospital outcomes such as increased mortality risk, the need for mechanical ventilation, and increased healthcare utilization.
An Eye-Tracking Study on Six Early Social-Emotional Abilities in Children Aged 1 to 3 Years
Authors: Cavadini Thalia , Riviere Elliot , Gentaz Edouard
Published: August 2024

Background: The experimental evaluation of young children’s socio-emotional abilities is limited by the lack of existing specific measures to assess this population and by the relative difficulty for researchers to adapt measures designed for the general population. Methods: This study examined six early social-emotional abilities in 86 typically developing children aged 1 to 3 years using an eye-tracking-based experimental paradigm that combined visual preference tasks adapted from pre-existing infant studies. Objectives: The aim of this study is to obtain developmental norms in six early social-emotional abilities in typical children aged 1 to 3 years that would be promising for an understanding of disorders of mental development. These developmental standards are essential to enable comparative assessments with children with atypical development, such as children with Profound Intellectual and Multiple Disabilities (PIMD). Results: The participants had greater spontaneous visual preferences for biological (vs. non-biological) motion, socially salient (vs. non-social) stimuli, the eye (vs. mouth) area of emotional expressions, angry (vs. happy) faces, and objects of joint attention (vs. non-looked-at ones). Interestingly, although the prosocial (vs. antisocial) scene of the socio-moral task was preferred, both the helper and hinderer characters were equally gazed at. Finally, correlational analyses revealed that performance was neither related to participants’ age nor to each other (dismissing the hypothesis of a common underpinning process). Conclusion: Our revised experimental paradigm is possible in infants aged 1 to 3 years and thus provides additional scientific proof on the direct assessment of these six socio-emotional abilities in this population.
Relationship of Social–Emotional Learning, Resilience, Psychological Well-Being, and Depressive Symptoms with Physical Activity in School-Aged Children
Authors: Belaire Evan , Mualla Fawzi , Ball Lucas , Ma Iris , Berkey Debra , Chen Weiyun
Published: August 2024

Background: This study investigated the association of psychological well-being (PWB), resilience, depressive symptoms, and social–emotional learning (SEL) with physical activity (PA) in school-aged children. The objective was to understand how these psychosocial factors influence PA levels and identify gender-specific differences in these relationships. Methods: This cross-sectional study involved 534 fourth grade and sixth grade students from eight schools in the Midwest region of the United States, with data collected through a Qualtrics survey. Multiple linear regression models were used to analyze the data, with gender-specific analyses conducted to identify differences between boys and girls. Results: The models indicated that all psychosocial factors taken together are significantly associated with PA (F = 26.937, p < 0.001). Of the factors, PWB and resilience were associated with higher PA individually for the total sample (β = 0.383, p = 0.001; β = 0.146, p = 0.005). A gender-specific analysis revealed that all factors collectively were significantly associated with PA in boys and girls (F = 15.846, p < 0.001; F = 6.869, p < 0.001). Individually, PWB and resilience were significantly associated with PA in boys (β = 0.358, p = 0.001; β = 0.171, p = 0.013), while only PWB was significantly associated with PA in girls (β = −0.355, p = 0.001). Conclusions: This study highlights the necessity of promoting resilience and psychological well-being through structured physical activities, aiming to reduce the risk of obesity and improve mental health among children. Future research should consider longitudinal designs and objective measures to further elucidate these relationships and inform effective educational strategies.