bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of ball‐milling treatment on mussel (Mytilus edulis) protein: structure, functional properties and in vitro digestibility
Authors: Yu Cuiping , Cha Yue , Wu Fan , Fan Weiwei , Xu Xianbing , Du Ming
Published: November 2017

In this study, the effects of ball‐milling treatment on structural properties and functional properties of mussel protein were investigated. In vitro protein digestibility and free amino acid contents were also evaluated. Ball‐milling treatment did not change the primary structure of mussel protein, but caused changes of secondary structure. The tertiary and quaternary structure also changed. After 20 min of ball‐milling treatment, the whiteness and oil‐binding capability of mussel protein significantly improved from 13.67 to 26.62 and 43.76% to 196.00%, while the protein solubility and water‐holding capability of mussel protein significantly decreased from 74.89% to 53.10% and 215.67% to 90.91%. Ball‐milling treatment increased the in vitro digestibility significantly. These results provide theoretical basis for the utilisation of mussel protein in food industry.
Modeling environmentally induced property degradation of SiC/BN/SiC ceramic matrix composites
Authors: Parthasarathy Triplicane A. , Cox Brian , Sudre Olivier , Przybyla Craig , Cinibulk Michael K.
Published: November 2017

The degradation of SiC‐based ceramic matrix composites (CMCs) in conditions typical of gas turbine engine operation proceeds via the stress rupture of fiber bundles. The degradation is accelerated when oxygen and water invade the composite through matrix microcracks and react with fiber coatings and the fibers themselves. We review micromechanical models of the main rate‐determining phenomena involved, including the diffusion of gases and reaction products through matrix microcracks, oxidation of SiC (in both matrix and fibers) leading to the loss of stiffness and strength in exposed fibers, the formation of oxide scale on SiC fiber and along matrix crack surfaces that cause the partial closure of microcracks, and the concomitant and synergistic loss of BN fiber coatings. The micromechanical models could be formulated as time‐dependent coupled differential equations in time, which must be solved dynamically, e.g., as an iterated user‐defined material element, within a finite element simulation. A paradigm is thus established for incorporating the time‐dependent evolution of local material properties according to the local environmental and stress conditions that exist within a material, in a simulation of the damage evolution of a composite component. We exemplify the calibration of typical micromechanical degradation models using thermodynamic data for the oxidation and/or volatilization of BN and SiC by oxygen and water, mechanical test data for the rate of stress rupture of SiC fibers, and kinetic data for the processes involved in gas permeation through microcracks. We discuss approaches for validating computational simulations that include the micromechanical models of environmental degradation. A special challenge is achieving validated predictions of trends with temperature, which are expected to vary in a complex manner during use.
Properties and structures of nonstoichiometric (K, Na)NbO3‐based lead‐free ceramics
Authors: Xing Jie , Tan Zhi , Xie Lixu , Jiang Laiming , Yuan Jing , Chen Qiang , Wu Jiagang , Zhang Wen , Xiao Dingquan , Zhu Jianguo
Published: November 2017

The 0.968[(K0.48Na0.52)]Nb0.95+xSb0.05O3–0.032(Bi0.5Na0.5)ZrO3 [KNNxS–BNZ] lead‐free ceramics with nonstoichiometric niobium ion were fabricated via conventional solid‐state sintering technique and their piezoelectric, dielectric and ferroelectric properties were investigated. When x = 0.010, enhanced piezoelectric properties (d33 ≈ 421 pC/N and kp ≈ 0.47) were obtained due to the construction of rhombohendral—tetragonal phase boundary near room temperature. The KNNxS–BNZ ceramics possesses enhanced Curie temperature (Tc) with improved piezoelectric constant. A large d33 of ~421 pC/N and a high Tc ~256°C can be simultaneously induced in the ceramics with x = 0.010. Especially, good thermal stability was observed in a broad temperature range. The results indicated that our work could benefit development of KNN‐based ceramics and widen their application range.
Switching from low‐dose thiazide diuretics to sodium–glucose cotransporter 2 inhibitor improves various metabolic parameters without affecting blood pressure in patients with type 2 diabetes and hypertension
Authors: Kimura Tomohiko , Sanada Junpei , Shimoda Masashi , Hirukawa Hidenori , Fushimi Yoshiro , Nishioka Momoyo , Kinoshita Tomoe , Okauchi Seizo , Obata Atsushi , Kohara Kenji , Tatsumi Fuminori , Kamei Shinji , Nakanishi Shuhei , Mune Tomoatsu , Kaku Kohei , Kaneto Hideaki
Published: November 2017

Aims/Introduction

Sodium–glucose cotransporter 2 (SGLT2) inhibitors function to increase urinary glucose excretion and improve glycemic control in individuals with type 2 diabetes mellitus. SGLT2 inhibitors, as well as diuretics, increase urinary volume, which leads to the reduction of blood pressure. The aim of the present study was to compare the effects of SGLT2 inhibitor and thiazide diuretic on blood pressure, metabolic parameters and body mass composition.

Materials and Methods

A total of 31 participants were enrolled in the present study. We switched from thiazide diuretics to an SGLT2 inhibitor, ipragliflozin, in participants with type 2 diabetes and hypertension whose blood pressure was controlled with thiazide diuretics. Three months after the switch, we evaluated the effects of such switching on blood pressure, various metabolic parameters and body mass composition.

Results

There was no significant difference in blood pressure from baseline to 3 months later. However, glycated hemoglobin, fasting plasma glucose and uric acid were significantly decreased after the switch. Body mass index and visceral fat area were also significantly reduced after the switch. Furthermore, urinary albumin excretion was also significantly decreased after the switch.

Conclusions

Switching from thiazide diuretic to an SGLT2 inhibitor, ipragliflozin, markedly improved various metabolic parameters and body mass composition without affecting blood pressure in participants with type 2 diabetes and hypertension.
Piling On? An Empirical Study of Parallel Derivative Suits
Authors: Choi Stephen J. , Erickson Jessica , Pritchard A. C.
Published: November 2017

Using a sample of all companies named as defendants in securities class actions between July 1, 2005 and December 31, 2008, we study parallel suits relying on state corporate law arising out of the same allegations as the securities class actions. We test several ways that parallel suits may add value to a securities class action. Most parallel suits target cases involving obvious indicia of wrongdoing. Moreover, we find that although a modest percentage of parallel suits are filed first, over 80 percent are filed after a securities class action (termed “follow‐on” parallel suits). We find that parallel suits and, in particular, follow‐on parallel suits sometimes target individual officers not already named as defendants in the securities class action. Suing more officers, however, does not positively correlate with an increase in settlement incidence, monetary recovery amounts, or attorney fees. Parallel suits sometimes result in settlements when the corresponding class action is dismissed; however, only rarely do the parallel suit settlements provide monetary recovery for investors. We find that follow‐on parallel suits often result in nonmonetary, corporate governance settlements, particularly for frequent‐filing plaintiffs’ attorneys. Corporate governance settlements correlate with significantly lower attorney hours and attorney fees for the plaintiffs’ attorneys. We conclude that such settlements are used to justify fees in cases in which there is no monetary recovery.
Rubrioxytricha guamensis nov. spec. (Ciliophora, Spirotricha), a Novel Hypotrich Ciliate from Guam (United States), Micronesia
Authors: Kumar Santosh , Bharti Daizy , Kabir Ahmed Salahuddin , Hong Jun Seo , Shin Mann Kyoon
Published: November 2017

The oxytrichid ciliate Rubrioxytricha guamensis nov. spec. isolated from water samples collected from a small freshwater pond near the Hagåtña River in Hagåtña, Guam (United States territory), Micronesia, was investigated, using live observation and protargol impregnation. The morphology, ontogenesis, and molecular phylogeny inferred from the small‐subunit rRNA gene sequences were studied. The new species is mainly characterized by a cell size of about 100 × 35 μm in vivo, two elongate ellipsoidal macronuclear nodules and two micronuclei, a single contractile vacuole, a colorless cytoplasm, yellowish cortical granules, arranged in short rows and in small groups, an adoral zone occupying about 34% of body length and comprising 27 membranelles on average, about 27 cirri each in the right and left marginal rows, 18 frontoventral transverse cirri, four dorsal kineties including one dorsomarginal row, and one or two caudal cirri at the posterior end of dorsal kinety 3. The ontogenesis of the new species is similar to that of Rubrioxytricha indica Naqvi et al., 2006. Phylogenetic analyses based on SSU rRNA gene sequences consistently place the new species within the family Oxytrichidae Ehrenberg, 1838, where it clustered with other Rubrioxytricha species, viz., R. tsinlingensis, R. ferruginea, and R. haematoplasma.
Urinary Fibrin Degradation Products in the Newborn
Authors: DAWSON K. P. , FLACK M.
Published: November 2017

Dawson, K. P. and Flack, M. (1978).Aust. Paediatr. J.,14, 147–149. Urinary fibrin degradation products in the newborn. A group of newborn Infants had urinary FDP levels measured during the first week of life. During this time the urine contained high levels of FDP which were present in some infants for seven days. The general trend was one of high levels in the first three days with a gradual subsidence thereafter. There appeared to be no relation to gestation, birth weight or mode of delivery.
Two Methods of Administering Nebulized Salbutamol
Authors: WOOD D. O. , CHANDLER DIANNE , DUGDALE A. E.
Published: November 2017

Wood, D. O., Chandler, Dianne and Dugdale, A. E. (1978). Aust. Paediatr. J., 14, 150–153. Two methods of administering nebulized salbutamol. A controlled study. A cross‐over study has been designed to test the efficiencies of two methods of delivering a continuous aerosol of salbutamol to children with acute wheezing and respiratory distress. The methods used were the conventional face mask and a wide bore tube which the child held In his mouth. Statistical analysis of the change in lung function tests following the two methods of administration showed no significant differences in effectiveness. A child should be allowed to use either mask or tube for delivery of aerosols or bronchodilators depending on his preference.
The Effect of Racial Origin, Geographical Location and Antenatal Care on an Infant's Birth Weight
Authors: COX J. W.
Published: November 2017

Cox, J. W. (1978). Aust. Paediatr. J., 14, 165–168. The effect of racial origin, geographical location and antenatal care on an infant's birth weight. The birth weight of infants from five rural areas of Queensland are reported and compared with geographical location and ethnic origin of parents. Among the Aboriginal infants, birth weights vary according to location, with the lightest being found in the northernmost section of Cape York. Aboriginal infants were lighter than non‐Aboriginals from the same area. It is postulated that these differences are affected by the degree of antenatal care.
Pyrimethamine in Experimental Amoebic Meningoencephalitis
Authors: THONG Y. H. , ROWAN-KELLY B. , FERRANTE A.
Published: November 2017

Thong, Y. H., Rowan-Kelly, B. and Ferrante, A. (1978). Aust. Paediatr. J., 14, 177–179. Pyrimethamine in experimental amoebic meningoencephalitis. The effect of pyrimethamine against Naegleria fowleri was tested in‐vitro and in‐vivo. Growth inhibition of the amoebae was observed at the concentration of 100 μg/ml of axenic culture. However, there was no effect on mortality of mice infected with the organism.
Oesophagitis and Oesophageal Obstruction from Quinidine Tablets in Association With Left Atrial Enlargement
Authors: BOHANE T. D. , PERRAULT J. , FOWLER R. S.
Published: November 2017

Bohane, T. D., Perrault, J. and Fowler, R. S. (1978). Aust. Paediatr. J., 14, 191–192. Oesophagitis and oesophageal obstruction from quinidine tablets in association with left atrial enlargement: A case report. A 12‐year‐old girl with left atrial enlargement developed oesophagitis and oesophageal obstruction following administration of quinidine bisulphate tablets, a sustained‐release quinidine preparation. Substitution by powdered quinidine sulphate resulted in rapid disappearance of all oesophageal symptoms. Left atrial enlargement may result in delayed passage of potentially irritant tablets and lead to oesophagitis which further aggravates oesophageal obstruction.
The combined and individual impact of diabetes and smoking on key subgingival periodontal pathogens in patients with chronic periodontitis
Authors: Joaquim C. R. , Miranda T. S. , Marins L. M. , Silva H. D. P. , Feres M. , Figueiredo L. C. , Duarte P. M.
Published: November 2017

Background and Objective

Comprehension of the similarities and differences in the composition of the subgingival microbiota of patients with diabetes mellitus (DM), smokers or smokers with DM is an important step in developing therapies specific for these groups at risk for periodontitis. Therefore, the aim of this study was to compare the combined and individual effects of DM and smoking on the levels and prevalence of key subgingival periodontal pathogens in patients with chronic periodontitis.

Material and Methods

One hundred patients with generalized chronic periodontitis were allocated into one of the following groups: DM (n = 25, non‐smokers with type 2 DM); S (n = 25, non‐diabetic smokers); SDM (n = 25, smokers with type 2 DM); and control (n = 25, non‐diabetic non‐smokers). Two subgingival biofilm samples from healthy sites (probing depth and clinical attachment level ≤3 mm and no bleeding) and 2 from diseased sites (probing depth and clinical attachment level ≥5 mm and bleeding on probing) were analyzed by quantitative polymerase chain reaction for Porphyromonas gingivalis, Tannerella forsythia, Treponema denticola, Eubacterium nodatum, Parvimonas micra, Fusobacterium nucleatum ssp. and Prevotella intermedia.

Results

There were no differences among groups in the mean counts of the bacterial species studied, considering all sampled sites (healthy plus diseased sites). There were also no differences among groups regarding the prevalence of any bacteria species in healthy and diseased sites (P > .05). The mean P. micra count was significantly higher in the healthy sites of both smoking groups, than in those of the control group (P < .05).

Conclusion

The subgingival levels and prevalence of the bacterial species studied are not significantly different in subjects with chronic periodontitis presenting DM, smokers or smokers with DM. In addition, DM and smoking, jointly and individually, do not considerably affect the subgingival levels of target periodontal pathogens in patients with chronic periodontitis.
Trans Feminism: Recent Philosophical Developments
Authors: Bettcher Talia Mae
Published: November 2017

This article introduces trans feminism as an intersectional analysis of sexist and transphobic forms of oppressions as well as current and historical feminist and trans conflicts over the inclusion of trans women. The first half examines recent feminist philosophical efforts to provide an analysis of the concept woman that is inclusive of trans women. The second examines recent responses to trans‐exclusive feminist positions. The article concludes with an assessment of the current state of trans feminist philosophy and outlines challenges for the future.
Outer membrane efflux protein (OMEP) is a suitable molecular marker for resolving the phylogeny and taxonomic status of closely related cyanobacteria
Authors: Moten Dzhemal , Batsalova Tsvetelina , Basheva Diyana , Mladenov Rumen , Dzhambazov Balik , Teneva Ivanka
Published: November 2017

Taxonomy of Cyanobacteria, the oldest phototrophic prokaryotes, is problematic for many years due to their simple morphology, high variability and adaptability to diverse ecological niches. After introduction of the polyphasic approach, which is based on the combination of several criteria (molecular sequencing, morphological and ecological), the whole classification system of these organisms is subject to reorganization. The aim of this study was to evaluate whether the outer membrane efflux protein (OMEP) sequences can be used as a molecular marker for resolving the phylogeny and taxonomic status of closely related cyanobacteria. We have performed phylogenetic analyses based on the amino acid sequences of the OMEP and the DNA sequences of the 16S rRNA gene from 86 cyanobacterial species/strains with completely sequenced genomes. Phylogenetic trees based on the OMEP showed that most of the cyanobacterial species/strains belonging to different genera are clustered in separate clades supported by high bootstrap values. Comparing the OMEP trees with the 16S rDNA tree clearly showed that the OMEP is more suitable marker in resolving phylogenetic relationships within Cyanobacteria at generic and species level.
Influenza and Pneumocystis jirovecii pneumonia in an allogeneic hematopoietic stem cell transplantation recipient: Coinfection or superinfection?
Authors: Burke Jacob , Soubani Ayman O.
Published: November 2017

Influenza infection and Pneumocystis jirovecii pneumonia (PJP) in hematopoietic stem cell transplant (HSCT) patients are well characterized; however, no dual infections have been reported in this patient population and little evidence of mechanisms of interaction between the two infections exists. We present a 53‐year‐old male allogeneic HSCT patient on immunosuppressive therapy for the treatment of graft versus host disease initially diagnosed with influenza A H3 and later PJP. Despite the development of acute respiratory distress syndrome, the patient was successfully treated with appropriate antimicrobial therapy and aggressive supportive care. This case demonstrates the necessity of maintaining a high index of suspicion for fungal (including PJP) coinfection or superinfection in the setting of worsening influenza infection.
Scedosporium apiospermum infection of the urinary system with a review of treatment options and cases in the literature
Authors: Benamu Esther , Yu Alexander Tin‐Han , Xie Lijia , Fernandez‐Pol Sebastian , Liu Anne Y. , Ho Dora Y.
Published: November 2017

Infection with Scedosporium species is associated with a significant morbidity and mortality and is becoming increasingly common, especially in immunocompromised patients. We describe the presentation and successful management of an immunocompromised patient with Scedosporium apiospermum infection of the upper urinary tract system, a rare disease manifestation. The current literature on urinary tract scedosporiosis is further reviewed with emphasis on treatment options and limitations of current antifungal therapy.
Magnetic resonance imaging features of canine gliomatosis cerebri
Authors: Schweizer‐Gorgas Daniela , Henke Diana , Oevermann Anna , Lang Johann , Vandevelde Marc , Steffen Frank
Published: November 2017

A retrospective, case series study was undertaken to identify magnetic resonance imaging (MRI) characteristics of gliomatosis cerebri in dogs. Fourteen dogs were included by review of histopathological records and contemporaneous MRI. On MRI, all lesions presented as ill‐defined, intraaxial lesions within the left and right forebrain hemispheres with involvement of white and gray matter. Lesions presented as hyperintense areas on T2‐weighted and FLAIR sequences and as hypointense or isointense areas on T1‐weighted images, with mild parenchymal contrast enhancement in three dogs. Signal changes were noted in three to 10 cerebral lobes. Other most commonly affected structures were the thalamus (13), caudate nucleus (13), interthalamic adhesion (11), hypothalamus (11), callosal commissure (10), hippocampus (9), and quadrigeminal plate (8). Abnormalities within the caudal fossa were noted in 10 dogs. Solid tumor portions were identified in five dogs. The histopathological examination demonstrated in all dogs a widespread diffuse infiltration with neoplastic glial cells in white and gray matter with meningeal infiltration. Comparison between MRI and histopathology showed that all areas with signal changes on MRI corresponded to diffuse and dense infiltration with neoplastic cells. The signal intensity on T2‐weighted and FLAIR images reflected the density of neoplastic cells. In all dogs, MRI underestimated lesion extent and meningeal infiltration. Involvement of the caudal fossa was not seen on MRI in three dogs. Despite this, MRI allowed identification of lesions extending into at least three cerebral lobes and therefore satisfying the criteria used for diagnosis of diffuse glioma with gliomatosis cerebri growth pattern in humans.
Studies of cortical connectivity using optical circuit mapping methods
Authors: Anastasiades Paul G. , Marques‐Smith Andre , Butt Simon J. B.
Published: November 2017

An important consideration when probing the function of any neuron is to uncover the source of synaptic input onto the cell, its intrinsic physiology and efferent targets. Over the years, electrophysiological approaches have generated considerable insight into these properties in a variety of cortical neuronal subtypes and circuits. However, as researchers explore neuronal function in greater detail, they are increasingly turning to optical techniques to bridge the gap between local network interactions and behaviour. The application of optical methods has increased dramatically over the past decade, spurred on by the optogenetic revolution. In this review, we provide an account of recent innovations, providing researchers with a primer detailing circuit mapping strategies in the cerebral cortex. We will focus on technical aspects of performing neurotransmitter uncaging and channelrhodopsin‐assisted circuit mapping, with the aim of identifying common pitfalls that can negatively influence the collection of reliable data.

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Exergy Analysis and Performance Assessment for Different Recuperative Thermodynamic Cycles for Gas Turbine Applications
Authors: Salpingidou Christina , Misirlis Dimitrios , Vlahostergios Zinon , Donnerhack Stefan , Flouros Michael , Goulas Apostolos , Yakinthos Kyros
Published: November 2017

This work presents an exergy analysis and performance assessment of three recuperative thermodynamic cycles for gas turbine applications. The first configuration is the conventional recuperative (CR) cycle in which a heat exchanger is placed after the power turbine (PT). In the second configuration, referred as alternative recuperative (AR) cycle, a heat exchanger is placed between the high pressure and the PT, while in the third configuration, referred as staged heat recovery (SHR) cycle, two heat exchangers are employed, the primary one between the high and PTs and the secondary at the exhaust, downstream the PT. The first part of this work is focused on a detailed exergetic analysis on conceptual gas turbine cycles for a wide range of heat exchanger performance parameters. The second part focuses on the implementation of recuperative cycles in aero engines, focused on the MTU-developed intercooled recuperative aero (IRA) engine concept, which is based on a conventional recuperation approach. Exergy analysis is applied on specifically developed IRA engine derivatives using both alternative and SHR recuperation concepts to quantify energy exploitation and exergy destruction per cycle and component, showing the amount of exergy that is left unexploited, which should be targeted in future optimization actions.
Histopathological Nature of Myofascial Trigger Points at Different Stages of Recovery from Injury in a Rat Model
Authors: Zhang Hui , Lü Jiao-Jiao , Huang Qiang-Min , Liu Lin , Liu Qing-Guang , Eric Opoku-Antwi
Published: November 2017

Objective

To investigate the histopathological nature of myofascial trigger points (MTrPs) or spots (MTrSs) at different stages of recovery from injury in a rat model.

Methods

Forty Sprague–Dawley rats were randomly divided into two groups: a control group (CG) and experimental group (EG). The CG was further randomly subdivided into CG1 and CG2 subgroups. The CG2 was used for palpating the taut band and CG1 as a blank. EG was subdivided into three groups according to recovery times: 4 weeks (4W), 8 weeks (8W) and 12 weeks (12W); these groups consisted of eight rats each. All CG rats received no intervention, whereas the intervention in EG rats was by a blunt strike to the vastus medialis and eccentric exercise for 8 weeks. The taut bands with spontaneous electrical activity were then detected in the muscle to guide a muscle biopsy. The histopathological findings were investigated under optical and electron microscopes in all groups.

Results

Under optical microscopy, the differently augmented sizes of round fibres (contracture knots) with deep staining in the transverse section and fusiform shapes in a longitudinal view were clearly seen in CG2 and EGs with a large diameter; the number of contracture knots was significantly more in EGs than in CGs. Under an electron microscope, the mitochondria in EGs significantly decreased with abnormal structures. The sarcomeres were significantly shortened in the 8W and 12W EGs.

Conclusion

An injury can cause activation of MTrSs in a muscle and an activated level of MTrPs depending on the number of contracture knots in muscle with impaired energy production.
SRSF6-regulated alternative splicing that promotes tumour progression offers a therapy target for colorectal cancer
Authors: Wan Ledong , Yu Wenying , Shen Enhui , Sun Wenjie , Liu Yuan , Kong Jianlu , Wu Yihua , Han Fengyan , Zhang Lei , Yu Tianze , Zhou Yuwei , Xie Sunzhe , Xu Enping , Zhang Honghe , Lai Maode
Published: November 2017

Objective

To investigate the molecular function of splicing factor SRSF6 in colorectal cancer (CRC) progression and discover candidate chemicals for cancer therapy through targeting SRSF6.

Design

We performed comprehensive analysis for the expression of SRSF6 in 311 CRC samples, The Cancer Genome Atlas and Gene Expression Omnibus (GEO) database. Functional analysis of SRSF6 in CRC was performed in vitro and in vivo. SRSF6-regulated alternative splicing (AS) and its binding motif were identified by next-generation RNA-sequencing and RNA immunoprecipitation sequencing (RIP-seq), which was validated by gel shift and minigene reporter assay. ZO-1 exon23 AS was investigated to mediate the function of SRSF6 in vitro and in vivo. Based on the analysis of domain-specific role, SRSF6-targeted inhibitor was discovered de novoby virtual screening in 4855 FDA-approved drugs and its antitumour effects were evaluated in vitroand in vivo.

Results

SRSF6 was frequently upregulated in CRC samples and associated with poor prognosis, which promoted proliferation and metastasis in vitro and in vivo. We identified SRSF6-regulated AS targets and discovered the SRSF6 binding motif. Particularly, SRSF6 regulates ZO-1 aberrant splicing to function as an oncogene by binding directly to its motif in the exon23. Based on the result that SRSF6 RRM2 domain plays key roles in regulating AS and biological function, indacaterol, a β2-adrenergic receptor agonist approved for chronic obstructive pulmonary disease treatment, is identified as the inhibitor of SRSF6 to suppress CRC tumourigenicity.

Conclusions

SRSF6 functions the important roles in mediating CRC progression through regulating AS, and indacaterol is repositioned as an antitumour drug through targeting SRSF6.

Accession numbers

The accession numbers for sequencing data are SRP111763 and SRP111797.
One-loop polarization operator of the quantum gauge superfield for 𝒩 = 1 SYM regularized by higher derivatives
Authors: Kazantsev A. E. , Skoptsov M. B. , Stepanyantz K. V.
Published: November 2017

We consider the general [Formula: see text] supersymmetric gauge theory with matter, regularized by higher covariant derivatives without breaking the BRST invariance, in the massless limit. In the [Formula: see text]-gauge we obtain the (unrenormalized) expression for the two-point Green function of the quantum gauge superfield in the one-loop approximation as a sum of integrals over the loop momentum. The result is presented as a sum of three parts: the first one corresponds to the pure supersymmetric Yang–Mills theory in the Feynman gauge, the second one contains all gauge-dependent terms, and the third one is the contribution of diagrams with a matter loop. For the Feynman gauge and a special choice of the higher derivative regulator in the gauge fixing term, we analytically calculate these integrals in the limit [Formula: see text]. In particular, in addition to the leading logarithmically divergent terms, which are determined by integrals of double total derivatives, we also find the finite constants.
Peculiar velocity measurement in a clumpy universe
Authors: Habibi Farhang , Baghram Shant , Tavasoli Saeed
Published: November 2017

Aims: In this work, we address the issue of peculiar velocity measurement in a perturbed Friedmann universe using the deviations from measured luminosity distances of standard candles from background FRW universe. We want to show and quantify the statement that in intermediate redshifts ([Formula: see text]), deviations from the background FRW model are not uniquely governed by peculiar velocities. Luminosity distances are modified by gravitational lensing. We also want to indicate the importance of relativistic calculations for peculiar velocity measurement at all redshifts. Methods: For this task, we discuss the relativistic correction on luminosity distance and redshift measurement and show the contribution of each of the corrections as lensing term, peculiar velocity of the source and Sachs–Wolfe effect. Then, we use the SNe Ia sample of Union 2, to investigate the relativistic effects, we consider. Results: We show that, using the conventional peculiar velocity method, that ignores the lensing effect, will result in an overestimate of the measured peculiar velocities at intermediate redshifts. Here, we quantify this effect. We show that at low redshifts the lensing effect is negligible compare to the effect of peculiar velocity. From the observational point of view, we show that the uncertainties on luminosity of the present SNe Ia data prevent us from precise measuring the peculiar velocities even at low redshifts ([Formula: see text]).
Investigation of triaxiality in 54122–128Xe isotopes in the framework of sdg-IBM
Authors: Jafarizadeh M. A. , Ranjbar Z. , Fouladi N. , Ghapanvari M.
Published: November 2017

In this paper, a transitional interacting boson model (IBM) Hamiltonian in both sd-(IBM) and sdg-IBM versions based on affine [Formula: see text] Lie algebra is employed to describe deviations from the gamma-unstable nature of Hamiltonian along the chain of Xe isotopes. sdg-IBM Hamiltonian proposed a better interpretation of this deviation which cannot be explained in the [Formula: see text]-boson models. The nuclei studied have well-known [Formula: see text] bands close to the [Formula: see text]-unstable limit. The energy levels, [Formula: see text] transition rates and signature splitting of the [Formula: see text] -vibrational band are calculated via the affine SU(1,1) Lie algebra. An acceptable degree of agreement was achieved based on this procedure. It is shown that in these isotopes the signature splitting is better reproduced by the inclusion of sdg-IBM. In none of them, any evidence for a stable, triaxial ground state shape is found.
ON ROBUST MULTI-PERIOD PRE-COMMITMENT AND TIME-CONSISTENT MEAN-VARIANCE PORTFOLIO OPTIMIZATION
Authors: CONG F. , OOSTERLEE C. W.
Published: November 2017

We consider robust pre-commitment and time-consistent mean-variance optimal asset allocation strategies, that are required to perform well also in a worst-case scenario regarding the development of the asset price. We show that worst-case scenarios for both strategies can be found by solving a specific equation each time step. In the unconstrained asset allocation case, the robust pre-commitment as well as the time-consistent strategy are identical to the corresponding robust myopic strategies, by which investors perform robust portfolio control only for one time step and conduct a risk-free strategy afterwards. In the experiments, the robustness of pre-commitment and time-consistent strategies is studied in detail. Our analysis and numerical results indicate that the time-consistent allocation strategy is more stable when possible incorrect assumptions regarding the future asset development are modeled and taken into account. In some situations, the time-consistent strategy can even generate higher efficient frontiers than the pre-commitment strategy (which is counter-intuitive), because the time-consistency restriction appears to protect an investor in such a situation.
Entanglement criteria for the three-qubit states
Authors: Akbari-Kourbolagh Y.
Published: November 2017

We present sufficient criteria for the entanglement of three-qubit states. For some special families of states, the criteria are also necessary for the entanglement. They are formulated as simple sets of inequalities for the mean values of certain observables defined as tensor products of Pauli matrices. The criteria are good indicators of the entanglement in the vicinity of three-qubit GHZ and W states and enjoy the capability of detecting the entangled states with positive partial transpositions. Furthermore, they improve the best known result for the case of W state mixed with the white noise. The efficiency of the criteria is illustrated through several examples.
Sequences of information backflow in local dephasing channels with spectral gaps
Authors: Giraldi Filippo
Published: November 2017

The flow of quantum information in local dephasing channels is analyzed over short and long times in case the structured reservoir of frequency modes exhibits a spectral gap in the density of modes over low frequencies. The presence of the low-frequency gap with upper cut-off frequency [Formula: see text] produces an infinite sequence of long-time intervals over which information backflow appears. Though generally irregular, the time intervals exhibit, under certain conditions, upper bounds: the [Formula: see text]th episode of information backflow has already started at the instant [Formula: see text], and already ended at the instant [Formula: see text], for every [Formula: see text]. The intervals become regular over long times, tend to the asymptotic length [Formula: see text], as the supremum value, and are described analytically in terms of the structure of the spectral density near the upper cut-off frequency of the spectral gap. Consequently, engineering structured reservoirs of frequency modes with a spectral gap over low frequencies produces in local dephasing channels regular sequences of information backflow and recoherence over long times, along with non-Markovian evolution.
Physical Transfer of Water Versus Virtual Water Trade: Economic and Policy Considerations
Authors: Dinesh Kumar M.
Published: November 2017

This paper provides a comparative economics of physical water transfer and virtual water trade in India to deal with the problem of growing scarcity of water. This is based on a nuanced understanding of the difficulties in operationalizing the concept of virtual water trade from a regional perspective; a better appreciation of the differential economic value of water use of land-rich, water-scarce regions and land-scarce, water-rich regions; and a recognition of the various direct and indirect benefits of large water transfer projects as evident from recent empirical studies. We first attempt a comparative economics of physical water transfer (between water-rich regions of eastern India to water-scarce regions of peninsular India) and the “virtual water transfer” alternative, considering the anecdotal evidence of various direct and indirect costs and benefits. The direct costs included economic cost of infrastructure, and various damage costs and transaction costs. The indirect costs covered economic, social and environmental costs. These cost components are several and are also more pronounced for physical water transfer. The benefits considered in the analysis included direct economic benefits, and various indirect benefits that are social, economic and environmental in nature. These benefits are several and also more pronounced for physical water transfer. The analysis showed that the net benefits of physical water transfer outweigh virtual water transfer. Subsequently, the political transaction costs of executing water transfer projects were examined.
Karst-specific composite model for informed resource management decisions on the Biosfera de la Reserva Selva el Ocote, Chiapas, Mexico
Authors: Kovarik Johanna L. , van Beynen Philip E.
Published: November 2017

High permeability and rapid recharge in karst aquifers make them susceptible to contamination. We combined a groundwater vulnerability map with an environmental disturbance index to give an adaptable spatial tool for developing management strategies for a karst environment in the Reserva de la Biosfera Selva el Ocote (el Ocote), Chiapas, Mexico. Seventy-two per cent of the study area is classified as an area of least concern for management, with 60% falling within el Ocote. Consequently, although there are concerns regarding the vulnerability of the karst ecosystem, the lack of development and the natural protection of the ecosystem, the immediate need for remedial action by the area's managers is currently minimal. About 27% of the study area is classified by the composite model as of moderate concern, with 34% within el Ocote. This reflects a balance between areas of moderate and high vulnerability, but little disturbance. Based on the management zones created by this study, much of the sub-catchment is zoned as of least or moderate concern, where disturbance has not occurred. As such, the opportunity exists to prevent major human impacts on vulnerable areas and the entire ecosystem, but only if local stakeholders are incorporated into this process of limiting development.
Characterization and hydraulic behaviour of the complex karst of the Kaibab Plateau and Grand Canyon National Park, USA
Authors: Jones Casey J. R. , Springer Abraham E. , Tobin Benjamin W. , Zappitello Sarah J. , Jones Natalie A.
Published: November 2017

The Kaibab Plateau and Grand Canyon National Park in the USA contain both shallow and deep karst systems, which interact in ways that are not well known, although recent studies have allowed better interpretations of this unique system. Detailed characterization of sinkholes and their distribution on the surface using geographical information system and LiDAR data can be used to relate the infiltration points to the overall hydrogeological system. Flow paths through the deep regional geological structure were delineated using non-toxic fluorescent dyes. The flow characteristics of the coupled aquifer system were evaluated using hydrograph recession curve analysis via discharge data from Roaring Springs, the sole source of the water supply for the Grand Canyon National Park. The interactions between these coupled surface and deep karst systems are complex and challenging to understand. Although the surface karst behaves in much the same way as karst in other similar regions, the deep karst has a base flow recession coefficient an order of magnitude lower than many other karst aquifers throughout the world. Dye trace analysis reveals rapid, conduit-dominated flow that demonstrates fracture connectivity along faults between the surface and deep karst. An understanding of this coupled karst system will better inform aquifer management and research in other complex karst systems.
Preliminary analysis of the decrease in water level of Vrana Lake on the small carbonate island of Cres (Dinaric karst, Croatia)
Authors: Bonacci Ognjen
Published: November 2017

A strong and potentially dangerous decreasing trend in the level of water in Vrana Lake over the last three decades was analysed. This freshwater lake is a unique karst hydrology feature located on the small Adriatic island of Cres (405.71 km
2
), which is entirely composed of carbonate rocks. The lake is situated in a large cryptodepression and its base reaches a depth of 61.3 m below mean sea-level. The lake is a complex hydrological–hydrogeological system with an average water volume of
c.
220 × 10
6
m
3
. The larger geographical region has been affected by an increase in air temperature over the last
c.
40 years. This exceptionally clean freshwater lake is the only source of potable water for the whole Cres archipelago. A dangerous drop in the water level of the lake started in 1983. This decreasing trend is driven by both global climate change and anthropogenic (the overexploitation of water) factors.
Posterior Estimates of Dynamic Constants in HIV Transmission Modeling
Authors: Chen Yingqing , Dale Renee , He Hongyu , Le Quoc-Anh T.
Published: November 2017

In this paper, we construct a linear differential system in both continuous time and discrete time to model HIV transmission on the population level. The main question is the determination of parameters based on the posterior information obtained from statistical analysis of the HIV population. We call these parameters dynamic constants in the sense that these constants determine the behavior of the system in various models. There is a long history of using linear or nonlinear dynamic systems to study the HIV population dynamics or other infectious diseases. Nevertheless, the question of determining the dynamic constants in the system has not received much attention. In this paper, we take some initial steps to bridge such a gap. We study the dynamic constants that appear in the linear differential system model in both continuous and discrete time. Our computations are mostly carried out in Matlab.
The Prevalence of and Factors Associated with Neck, Shoulder, and Low-Back Pains among Medical Students at University Hospitals in Central Saudi Arabia
Authors: Algarni Abdulrahman D. , Al-Saran Yazeed , Al-Moawi Ahlam , Bin Dous Abdullah , Al-Ahaideb Abdulaziz , Kachanathu Shaji John
Published: November 2017

Aim. The study aim was to determine the prevalence of neck, shoulder, and low-back pains and to explore the factors associated with musculoskeletal pain (MSP) among medical students at university hospitals in central Saudi Arabia. Method. This cross-sectional study was conducted at a government institution using an online self-administered, modified version of the Standardised Nordic Questionnaire in the English language. Results. A total of 469 students responded to our survey. The prevalence of MSP in at least one body site at any time, in the past week, and in the past year was 85.3%, 54.4%, and 81.9%, respectively. Factors significantly associated with MSP in at least one body site at any time were being in the clinical year (P=0.032), history of trauma (P = 0.036), history of depressive symptoms (P<0.001), and history of psychosomatic symptoms (P<0.001). On multivariable regression analysis, factors associated with MSP were history of trauma (P=0.016) and depressive (P=0.002) or psychosomatic symptoms (P=0.004). Conclusion. MSP among Saudi medical students is high, particularly among those in the clinical years and those with history of trauma and with depressive or psychosomatic symptoms. Medical institutions should be aware of this serious health issue and preventive measures are warranted.
Effects of Concentration and Surface Pressure on MBP Interaction with Cholesterol in Langmuir Films
Authors: Zhang Lei , Hao Changchun , Xu Guoqing , Sun Runguang
Published: November 2017

Predicting the mechanism of MBP binding to cholesterol is meaningful in understanding how MBP participate in lateral membrane organization. The interaction of MBP with cholesterol monolayer was investigated at three surface pressures on 10 mM Tris-HCl buffer with the different concentrations of MBP. The results show thatπ-Aisotherms shift to larger molecular area at all pressures. By means of analyzingπ-Tcurves, a surface pressure increase was obtained. Results indicated that the greater the protein concentration in the subphase, the larger the increase of surface pressure. In addition, changes in monolayer surface morphology and domain formation were performed by AFM. These results provide more direct and convincing evidence for the MBP interaction with cholesterol. The MBP-cholesterol interaction suggests a significant concentrations and surface pressure dependence and is probably governed by hydrogen bonds. The date presented could help to understand at least one of the molecular mechanisms through which MBP affects lateral organization of the cholesterol membrane.
Experiences Providing Medical Assistance during the Sewol Ferry Disaster Using Traditional Korean Medicine
Authors: Kim Kyeong Han , Jang Soobin , Lee Ju Ah , Jang Bo-Hyoung , Go Ho-Yeon , Park Sunju , Jo Hee-Guen , Lee Myeong Soo , Ko Seong-Gyu
Published: November 2017

Background. This study aimed to investigate medical records using traditional Korean medicine (TKM) in Sewol Ferry disaster in 2014 and further explore the possible role of traditional medicine in disaster situation. Methods. After Sewol Ferry accident, 3 on‐site tents for TKM assistance by the Association of Korean Medicine (AKOM) in Jindo area were installed. The AKOM mobilized volunteer TKM doctors and assistants and dispatched each on‐site tent in three shifts within 24 hours. Anyone could use on‐site tent without restriction and TKM treatments including herb medicine were administered individually. Results. The total of 1,860 patients were treated during the periods except for medical assistance on the barge. Most patients were diagnosed in musculoskeletal diseases (66.4%) and respiratory diseases (7.4%) and circulatory diseases (8.4%) followed. The most frequently used herbal medicines were Shuanghe decoction (80 days), Su He Xiang Wan (288 pills), and Wuji powder (73 days). Conclusions. TKM in medical assistance can be helpful to rescue worker or group life people in open shelter when national disasters occur. Therefore, it is important to construct a rapid respond system using TKM resources based on experience.
Chemopreventive Potential of 2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside on the Formation of Aberrant Crypt Foci in Azoxymethane-Induced Colorectal Cancer in Rats
Authors: Lin Chien-Liang , Jeng Jiiang-Huei , Wu Chih-Chung , Hsieh Shu-Ling , Huang Guan-Cheng , Leung Wan , Lee Chining-Ting , Chen Chung-Yi , Lee Chien-Hsing
Published: November 2017

2,3,5,4′-Tetrahydroxystilbene-2-O-β-D-glucoside (THSG) has been shown to have antioxidative and anti-inflammatory effects. Oxidative and inflammatory reactions are related to the development of colorectal carcinoma (CRC). In the present study, we characterized the preventive activities of THSG on colon carcinogenesis using the azoxymethane- (AOM-) mediated rat colon carcinogenesis model. F344 male rats were randomly divided into 5 groups (untreated and AOM model rats treated with or without THSG at 30, 150, or 250 mg/kg) after which the numbers of aberrant crypt foci (ACF) were assessed in the colon tissues of all rats. The expressions of nuclear factor-κB (NF-κB), cyclooxygenase-2 (COX-2), matrix metalloproteinase proteins (MMPs), and carcinoembryonic antigen (CEA) were measured as effective early predictors of CRC using western blot analysis. Treatment with THSG (150 or 250 mg/kg) induced a 50% reduction in total colonic ACF formation (P<0.05). Furthermore, our results revealed a downregulation of CEA and NF-κB protein levels in the reduced number of ACF elicited by treatment with THSG, whereas levels of COX-2 and MMPs proteins were not changed. Collectively, THSG may be a promising natural lead compound or drug candidate for treating early phases of CRC.