bluuebunny/crossref_metadata_2025 huggingface dataset:
15-Year Long-Term Follow-Up on the Progression to Liver Cancer in a Patient with Alcoholic Hepatitis Who Continued Drinking: A Case Report and Clinical Approach
Authors: Cho Nahyun , Bae Hye-ri , Lee Nam-hun
Published: October 2024

Objectives: This case report aims to present the long-term clinical progression of a patient diagnosed with alcoholic hepatitis, which subsequently advanced to liver cirrhosis and hepatocellular carcinoma over a 15-year period. The report highlights the impact of continued alcohol consumption on the progression of alcoholic liver disease and provides a clinical analysis of the course of the disease.Methods: A single patient diagnosed with alcoholic hepatitis was analyzed retrospectively. The patient was treated with both traditional Korean medicine and conventional medicine over multiple hospitalizations between 2012 and 2021. Clinical outcomes were monitored through blood chemistry, imaging studies, and Child-Pugh scores.Results: Despite consistent treatment, the patient’s continued alcohol consumption accelerated the progression from alcoholic hepatitis to cirrhosis and, eventually, hepatocellular carcinoma. The patient’s condition remained classified as Child-Pugh B throughout the follow-up, and he ultimately expired in 2023.Conclusion: This case emphasizes that alcohol cessation is crucial in preventing the rapid progression from alcoholic hepatitis to liver cancer. Early detection through noninvasive fibrosis tests such as FibroScan, proactive management of complications, and the use of prognostic tools such as Maddrey Discriminant function (MDF), in addition to patient education, are essential for better outcomes.
CONJUGALIDADES E TRABALHO: Desemprego, vivências profissionais, vulnerabilidades e proteção
Authors: Santos Giovanna Beatriz dos , Camargo Mário Lázaro , Feijó Marianne Ramos
Published: October 2024

This article is the result of research that chose as its object of study the relationship established between experiences of employment or unemployment in marital partnerships. Considering that conjugal relationships are subject to influences arising from the broader context of their insertion, we sought to understand how work, or the lack thereof, resonates with them. The theoretical framework for analyzing the data collected through semi-structured interviews and treated using the content analysis technique was systemic-complex thinking. Therefore, the present study is characterized as empirical and qualitative, since 10 couples were interviewed, divided into two groups: in the first group, five couples composed of partners who, until the date of the interview, were employed; in the second group, five couples with at least one of the spouses unemployed. For inclusion purposes, we considered as research participants couples in a stable union or with a marital relationship made official by marriage, regardless of whether they are heterosexual or homoaffective. The research demonstrated the significant interdependence between employment, unemployment and the quality of marital relationships, both of which can sometimes present themselves as a protective factor, sometimes as a vulnerability factor. Through the valuable reports collected from the participating couples, it was possible to verify a still strong presence of gender issues around the theme of conjugality and work, that is, the couples interviewed are still very influenced by the heteronormative and sexist culture, which imputes to women a role of submission and less autonomy in relation to men.
A EXPERIÊNCIA DE PSICÓLOGOS CLÍNICOS FRENTE AOS DESAFIOS NO MANEJO DO PACIENTE COM RISCO DE SUICÍDIO
Authors: Reul Marília Araújo , Gomes Tatiana Carneiro , Coutinho Ana Flávia Borba , Vieira Kay Francis Leal
Published: October 2024

The experience of a clinical psychologist dealing with a person in a suicidal crisis is a complex challenge that requires technical and emotional preparation. The objective was to understand the clinical experience and challenges of clinical psychologists when dealing with patients at risk of suicide. This is field research, of an applied and descriptive nature with a qualitative methodological approach. The study included 10 psychologists who have worked at the clinic for at least 1 year, with active registration with the Regional Council of Paraíba (CRP/13) and who have already helped or are helping people in crisis (suicidal). Data collection took place through a semi-structured interview with triggering questions, carried out in a virtual or in-person environment, with voice recording consented by signing the authorization form, respecting the ethical aspects of Resolution 510/16. The lexical analysis of the textual data was carried out using the software R and IRaMuTeQ, which allowed the separation of the corpus into five semantic classes, namely: Class 1 was called Psychology Care; 2 was called Meaning of life; 3, Reception; 4, Support network; to 5, Challenge; 6, Diagnostics; and class 7 was called Risk of suicide. Next, a Similarity Analysis was carried out, aiming to analyze the relationship and/or connection between the words. As a result, there was difficulty in contacting and involving the family in the psychotherapeutic process of the patient in crisis, with stigma and denial of emotional suffering being noticeable.
TRANSTORNOS MENTAIS COMUNS E QUALIDADE DE VIDA: Uma revisão sistemática em periódicos brasileiros
Authors: Gomes Francisco Vinicius Ferreira , Sousa Nadiel Cavalcante de , Martins Frankly Eudes Sousa
Published: October 2024

The objective of this article was to analyze studies whose themes were the association Common Mental Disorders and Quality of Life published in Brazilian journals. For this purpose, a systematic literature review was carried out, based on the survey of national empirical productions, available in the digital collection of the SciELO, Lilacs, Medline and Google Scholar indexes, and identified from the descriptors "Quality of Life" and "Common Mental Disorders". Articles written in Portuguese and carried out by Brazilian researchers, in the Brazilian context, published in Brazilian journals between the years 2006 and 2024 were included in this work. Consequently, articles published in another language, works in Portuguese published in international studies, and before 2006 and after 2024. After applying the criteria for selecting the articles, a total of 18 articles were obtained, which were read and evaluated. The findings showed a high prevalence of CMD, as well as different perceptions regarding QOL in the groups that participated in the studies and that were considered in this review. The results also pointed to a relationship between CMD and QOL assessment.
Regularities of decomposition of metastable phases in titanium pseudo-β-alloys
Authors: Kozlova I. R. , Vasilieva E. A. , Markova Yu. M.
Published: October 2024

The results of a study of metastable phase decomposition in a titanium pseudo-β-alloy are presented. The paper considers main patterns of evolution of the structure and phase composition of a high-alloy titanium grades with a thermally unstable β-phase depending on the heat treatment mode. The influence of the isothermal holding temperature on the morphology and degree of recrystallization of the precipitating phase is shown. The results of the study indicate that low-temperature decomposition of the metastable β-phase in the alloy leads to its embrittlement.
Structural features of composite electrochemical coatings nickel – diamond
Authors: Krasikov A. V.
Published: October 2024

The paper studies the structure of nickel-diamond composite electrochemical coatings obtained from the suspension electrolyte with ASM 7/5 powder. When the content of diamond powder in the electrolyte is 10 g/l, coatings are deposited with a uniform distribution of the reinforcing phase and a diamond volume fraction of up to 20%. Studies of the structure of the nickel coating matrix have revealed that, in comparison with standard galvanic nickel, which has a pronounced texture, the composite coating matrix has a finely dispersed structure with random grain orientation. Comparative measurements of nanohardness made it possible to record the strengthening of composite coatings matrix compared to galvanic nickel. Along with the high hardness of the reinforcing component and the relatively large particle size, this determines the high microhardness of the composite coating, which averages 860 HV.
Impacto orçamentário da incorporação do monitoramento intermitente de glicose para indivíduos com diabetes tipo 1
Authors: Carneiro de Freitas Nakata Kelli , Yugi Nakata Gilson , Mariana Guenkka Ternize
Published: October 2024

Objetivo: avaliar o potencial impacto orçamentário – IO decorrente da incorporação do sistema de monitoramento intermitente de glicose do tipo FreeStyle® para indivíduos com diabetes mellitus tipo 1- DM1. Métodos: as análises foram realizadas através do aplicativo excel para um horizonte temporal de 5 anos sob a perspectiva do estado de Mato Grosso. A população elegível, indivíduos com 18 anos ou mais com DM1 e hipoglicemia grave, foi selecionada com auxílio de uma síntese de evidência. As taxas de implantação assumidas para os anos de 1 a 5 foram: 27%; 30%; 33%; 36% e 40%, respectivamente com base na frequência com que os diabéticos brasileiros monitoram a glicose; na aceitação da tecnologia e na proporção de pessoas diabéticas com acesso a consulta e exames. Foi executada uma análise de sensibilidade bivariada modificando os parâmetros população e taxa de implantação, simultaneamente. Um cenário com uso de smartphones em substituição aos leitores foi simulado. Resultados: A população elegível foi de 2.522 indivíduos com um incremento de 2,6% para os anos subsequentes. O custo anual com sensores/indivíduo foi de R$7.774,00 e com o leitor de R$299,00/indivíduo para todo o horizonte temporal. No ano 1 e 5 o IO foi de R$ 5.497.228,62 e R$ 8.712.561,00 respectivamente. A substituição de leitores por smartphones não se mostrou sensível para o período considerado. Conclusões: o IO de uma possível incorporação do FreeStyle® é expressivo quando comparado ao montante de recurso orçamentário reservado para operacionalizar toda a política de assistência farmacêutica no estado de Mato Grosso.
Modernização da escrituração de psicotrópicos: a Portaria 344/98 precisa de atualização
Authors: Alexandre Oliveira Rodrigues Cássio , José Pinheiro Lopes Higor
Published: October 2024

Apesar das mudanças e avanços tecnológicos das últimas 3 décadas, onde as perspectivas dos serviços de saúde mudaram e a qualidade da prestação de serviço e a segurança do paciente são hoje os norteadores dos processos de assistência à saúde, nem todos os aspectos que envolve a assistência farmacêutica hospitalar progrediram;
A portaria 344/98 que regulamenta todos os aspectos legais dos medicamentos sujeitos à controle especial tornou-se obsoleta no que compete ao tópico de escrituração de medicamentos na medida em que ferramentas tecnológicas para registros das movimentações de medicamentos surgiram no cenário da assistência hospitalar;
Apesar da previsibilidade de uso de softwares de gestão hospitalar por instrução normativa vigente, as coordenadorias de vigilância sanitária (COVISA) ainda resistem ao uso de sistemas informatizados que realizam os registros de dados de produção, manipulação, distribuição, prescrição e dispensação de medicamentos psicotrópicos;
Diante desse cenário é salutar que as legislações também se atualizem e se adequem às mudanças e aos avanços tecnológicos a fim de não se tornarem obsoletas, que os legisladores acompanhem igualmente as mudanças dos cenários para propor as atualizações cabíveis e necessárias, e que a portaria 344/98 necessita de atualização.
Frullania stylifera (Frullaniaceae), a new addition to the liverwort flora of Canada
Authors: Caners Richard
Published: October 2024

Frullania stylifera (R.M. Schust.) R.M. Schust. (Frullaniaceae) is newly reported for Canada. The species grows closelyappressed to the bark of trees and shrubs and was recently documented from two areas of mature forest at Buffalo Point First Nation in extreme southeastern Manitoba, Canada. These localities represent a northern range extension for the species on the continent and include two new phorophyte hosts for North America. Features used to distinguish F. stylifera from other known species of Frullania in Manitoba are provided.
Exploration and implementation of a smart tourism destination with the 6As framework & TOPSIS (case study: Wakatobi, Indonesia)
Authors: Agustan  , Rianse Usman , Sukotjo Endro , Faslih Arman
Published: October 2024

Wakatobi represents huge potential for smart tourism due to the rich natural, cultural, and man-made resources available. The objective of the research is to identify and analyze the tourism potential of Wakatobi by using the 6As framework (attractions, accessibility, amenities, available packages, activities, and ancillary services) and applying the Technique for Order Preference by Similarity to Ideal Solution (TOPSIS) method to rank the potential tourist destinations. Field observations, collection of secondary data, and stakeholder interviews were conducted to arrive at comprehensive data on the tourism assets of the islands. The result of the exploration successfully recorded 160 attractions in the form of geographical destinations and activities with a variety of visitor facilities around them, which were measured using the 6As framework. The TOPSIS results indicated that Wangi-Wangi Island had the highest rank (0.87) in overall tourism potential compared to the others due to better infrastructural conditions, diverse attractions, and better facilities. Furthermore, it revealed major discrepancies among the islands, thus requiring focused improvements related to accessibility and services for less developed areas like Kaledupa (0.28), South Kaledupa (0.26), and Tomia (0.25). This study provides the basic insights for policymakers and stakeholders to invest in the right areas to ensure balanced and inclusive growth, increasing the tourism attractiveness of Wakatobi with a focus on sustainability and community involvement.
Effect of Hyperketonemia on Myocardial Function in Patients With Heart Failure and Type 2 Diabetes
Authors: Solis-Herrera Carolina , Qin Yuejuan , Honka Henri , Cersosimo Eugenio , Triplitt Curtis , Neppala Sivaram , Rajan Jemena , Acosta Francisca M. , Moody Alexander J. , Iozzo Patricia , Fox Peter , Clarke Geoffrey , DeFronzo Ralph A.
Published: October 2024

We examined the effect of increased levels of plasma ketones on left ventricular (LV) function, myocardial glucose uptake (MGU), and myocardial blood flow (MBF) in patients with type 2 diabetes (T2DM) with heart failure. Three groups of patients with T2DM (n = 12 per group) with an LV ejection fraction (EF) ≤50% received incremental infusions of β-hydroxybutyrate (β-OH-B) for 3–6 h to increase the plasma β-OH-B concentration throughout the physiologic (groups I and II) and pharmacologic (group III) range. Cardiac MRI was performed at baseline and after each β-OH-B infusion to provide measures of cardiac function. On a separate day, group II also received a sodium bicarbonate (NaHCO3) infusion, thus serving as their own control for time, volume, and pH. Additionally, group II underwent positron emission tomography study with 18F-fluoro-2-deoxyglucose to examine effect of hyperketonemia on MGU. Groups I, II, and III achieved plasma β-OH-B levels (mean ± SEM) of 0.7 ± 0.3, 1.6 ± 0.2, 3.2 ± 0.2 mmol/L, respectively. Cardiac output (CO), LVEF, and stroke volume (SV) increased significantly during β-OH-B infusion in groups II (CO, from 4.54 to 5.30; EF, 39.9 to 43.8; SV, 70.3 to 80.0) and III (CO, from 5.93 to 7.16; EF, 41.1 to 47.5; SV, 89.0 to 108.4), and did not change with NaHCO3 infusion in group II. The increase in LVEF was greatest in group III (P < 0.001 vs. group II). MGU and MBF were not altered by β-OH-B. In patients with T2DM and LVEF ≤50%, increased plasma β-OH-B level significantly increased LV function dose dependently. Because MGU did not change, the myocardial benefit of β-OH-B resulted from providing an additional fuel for the heart without inhibiting MGU.

Article Highlights
Additive manufacturing of polyamide 12 bulk structures using directed energy deposition with a thulium laser: Effect of process conditions on morphology and mechanical performance
Authors: Wittmann Alexander , Meth Claudia , Chamandani Saeed Alidoust , Vetter Johannes , Kopp Sebastian-Paul , Schmidt Michael
Published: October 2024

Laser-based directed energy deposition of polymers (DED-LB/P) is a highly flexible additive manufacturing process capable of fabricating three-dimensional structures with a high degree of customization on free-form surfaces. In this article, the manufacturability of polyamide 12 bulk structures using DED-LB/P in combination with a thulium laser operating at a wavelength of 1.94 μm is investigated for the first time. The typical absorption bands at this wavelength eliminate the need for additives such as carbon-based nanoparticles, which would limit the range of applications. The generated structures were analyzed regarding porosity, thermal behavior, and mechanical properties to evaluate the potential of DED-LB/P with a thulium laser. As a consequence of the evaporation of absorbed moisture or ethanol residues resulting from powder preparation, a thermal pretreatment of the polymer powder reduced the porosity of the DED-LB/P structures to 0.9%. Depending on the processing parameters, the crystallinity of the produced structures ranged from 25.6% to 29.9%. For the tensile tests, the required geometries were milled from the DED-LB/P bulk structures. The results show that an ultimate tensile strength of up to 52 MPa, an elongation at break of up to 58%, and Young's modulus of up to 1590 MPa can be achieved. These remarkable mechanical properties are primarily attributed to the complete melting of the powder particles in DED-LB/P and the improved surface quality resulting from the milling process.
Experimental Investigation on the Synthesis of Nanostructures Based on Fullerene C70 and Their Stability
Authors: Makhmanov Urol K
Published: October 2024

Nanostructures based on fullerene C70 are of great interest due to their wide application in modern branches of science and technology. In this work, a method for synthesizing nanostructures of various dimensions (nanoaggregates and nanowhiskers) of fullerene C70, based on the self-organization of C70 molecules during the evaporation of droplets of a solution of fullerene in ethylbenzene on the substrate surface, is proposed and implemented for the first time. It has been established that the onset of C70 nanowhisker synthesis during evaporation of C70 solution droplets on the substrate surface depends on the substrate temperature. Experimental evidence is presented that an increase in both the C70 concentration in the solution and the substrate temperature leads to an increase in the geometric dimensions of C70 nanowhiskers. The stability of the resulting nanostructures to high temperatures has been determined. The results obtained provide the necessary information on the role of solution concentration and substrate temperature in the synthesis of one-dimensional nanomaterials.
IMPLEMENTASI KEBIJAKAN PENYELENGGARAAN REKLAME DI KOTA TANJUNGPINANG TAHUN 2022
Authors: Adira Tiara Rossa , Nazak Nazak , Putra Ardi
Published: October 2024

Fenomena yang terjadi pada tahun 2022 adanya gesekan antara pemerintah kota Tanjungpinang dengan penyelenggara reklame karena mereka mengatakan selalu membayar pajak, papan reklame yang ditertibkan itu sudah ada yang berdiri hampir 10 tahun. Mereka merugi akibat penyegelan berdasarkan Peraturan Walikota Tanjungpinang No 70 Tahun 2021 tersebut. Pengusaha harus menunda bisnis reklame mereka karena, papan reklame disegel. Penertiban reklame yang berdiri tanpa izin disejumlah titik dikota Tanjungpinang, ternyata 244 konstruksi reklame, hanya sekitar 10 persen saja yang memiliki izin mendirikan persetujuan Bangunan Gedung (PBG). Penelitian ini bertujuan untuk melihat implementasi kebijakan penyelenggaran Reklame di Kota Tanjungpinang. Hasil penelitian menunjukkan bahwa implementasi kebijakan penyelenggaran reklame di Kota Tanjungpinang Tahun 2022 sebagian besar sudah berjalan dengan baik yang dilakukan sesuai pasal 49 tentang pengawasan tim penyelenggaraan reklame. Pada pelaksanaannya sesuai pasal 18 ayat 3 Dinas Penanaman Modal dan pelayanan Terpadu Satu Pintu selaku Dinas yang menyelenggarakan izin melaksanakan kebijakan penyelenggara izin sesuai dengan tugasnya. Satuan polisi pamong praja juga sebagai petugas penertiban reklame menjalankan tugas sesuai dengan wewenang yang diberikan sesuai dengan pasal 51 ayat 4. Temuan dilapangan mengatakan bahwa dalam hal perizinan banyak yang belum mengurus izin konstruksi hanya mengurus izin pemasangan konten dan membayar pajak konten. Penertiban yang terjadi sudah efektif dapat dilihat dari banyaknya reklame yang sudah ditertibkan. Dalam pengurusan izin lebih dimudahkan, dan melibatkan sasaran tujuan atau untuk mencapai tujuan dari kebijakan tersebut. Untuk para pengusaha reklame diharapkan setelah ini mendapatkan hak dan menjalankan kewajibannya sesuai peraturan penyelenggaraan reklame yang berlaku.
Opportunities and challenges in higher education arising from AI: A systematic literature review (2020–2024)
Authors: Cui Pengfei , Alias Bity Salwana
Published: October 2024

With society’s continuous development and progress, artificial intelligence (AI) technology is increasingly utilized in higher education, garnering increased attention. The current application of AI in higher education impacts teachers’ instructional methods and students’ learning processes. While acknowledging that AI advancements offers numerous advantages and contribute significantly to societal progress, excessive reliance on AI within education may give rise to various issues, students’ over-dependence on AI can have particularly severe consequences. Although many scholars have recently conducted research on artificial intelligence, there is insufficient analysis of the positive and negative effects on higher education. In this paper, researchers examine the existing literature on AI’s impact on higher education to explore the opportunities and challenges presented by this super technology for teaching and learning in higher educational institutions. To address our research questions, we conducted literature searches using two major databases—Scopus and Web of Science—and we selected articles using the PRISMA method. Findings indicate that AI plays a significant role in enhancing student efficiency in academic tasks and homework; However, when considering this issue from an ethical standpoint, it becomes apparent that excessive use of AI hinders the development of learners’ knowledge systems while also impairing their cognitive abilities due to an over-reliance on artificial technology. Therefore, our research provides essential guidance for stakeholders on the wise use of artificial intelligence technology.
Aerosol Impact on UV Solar Irradiance and Diffuse Fraction
Authors: Codrean Andrea , Bunoiu Madalin , Paulescu Marius
Published: October 2024

Aerosols modify the solar irradiance levels in the ultraviolet (UV) spectral band and, as a result, influence the magnitude of the biological effects of solar radiation. Also, aerosols contribute to the changes in nature (direct/diffuse) of the UV solar radiation received by a biological organism. This work quantitatively evaluates the aerosol effects on all components of solar UV irradiance (direct-normal, diffuse and global) under clear sky conditions. A note of originality is given by the wide perspective and the depth of detail in which the influence of aerosols in the UV band is captured. In addition to the common parameters, such as aerosol nature and the atmospheric aerosol loading, fine properties of aerosols, such as absorptivity and asymmetry factor, are considered. A distinctive feature of this study is given by the analysis of the effects of aerosols on the UV diffuse fraction. In general, changes in aerosol properties substantially change the direct-normal and diffuse components of UV solar irradiance and, to a lesser extent, the global component. The diffuse fraction in the UV band decreases notably with the increase of the Ångström turbidity coefficient and the Ångström exponent. Differently, the diffuse fraction is much less sensitive to the variation of the single scattering albedo and the asymmetry factor.
An evaluation rule to manage productivity properties performance of male date palms
Authors: Abdel-Sattar Mahmoud , Al-Obeed Rashid S. , Aboukarima Abdulwahed M. , Górnik Krzysztof , El-Badan Ghada E.
Published: October 2024

Male palm trees almost prominently display minute morphological variations; however, date palm growers rely on readily available pollen from unproven male genotypes without giving correct type selection any thought, which may result in low productivity and/or poor fruit quality. This study sought to develop an evaluation rule by calculating an evaluation index for managing the productivity characteristics performance of nine male date palms, which were examined for their pollen productivity, nutritional status and morphological traits from their leaves, pinnae and spathes. The findings showed that the evaluation rule for a male date palm should depend on pollen grains productivity and germination percentage traits with a weight of 5, spathe morphological traits with a weight of 4, pinnae morphological traits with a weight of 3, leaf morphological traits with a weight of 2 and leaf nutritional status with a weight of 1. The best productivity characteristics performance of male date palms was male No. 8 ‘M8’ due to its high evaluation index. The proposed evaluation index criterion will contribute to better information and analytical support for management of the date palm industry to maximise the effectiveness of germplasm conservation and exploitation, as well as procedural and methodological aspects of the analysis.
Die österreichische Wettbewerbsfähigkeit im Check
Authors: Sachs Andreas , Weiß Johann , Böhmer Michael
Published: October 2024

Austria's economy is highly competitive internationally in many areas. Nevertheless, there are various economic policy challenges. In addition, the intensity of international competition is increasing. A comparison of Austria's economic environment with 21 other highly developed economies based on comparable indicators that are available across the board shows the most important areas where action is needed. This contribution identifies the respective challenges in different areas and provides solutions. Finally, the growth effects of selected measures are quantified based on a model-based scenario calculation.
Limit Cycle Oscillation of Elastic Plate in Supersonic Flow
Authors: Freydin Maxim , Piccolo Serafim Luisa , Dowell Earl H. , Vaibhav Varigonda Santosh , Narayanaswamy Venkateswaran
Published: October 2024

Fluid–structure interaction of an elastic plate with piezoelectric elements, turbulent freestream flow at Mach 2.5, and a pressurized cavity is investigated computationally and correlated with a recent experiment. The pressure field on the plate is measured using pressure-sensitive paint, and the structural response is observed using the measured voltage of a piezoelectric patch. The measurements show a dominant frequency of oscillation which indicates the likely onset of flutter and a postflutter limit cycle oscillation (LCO). A computational investigation is conducted to study the effects of static pressure differential, temperature differential, cavity pressure coupling, and plate boundary conditions on the linear flutter onset condition and the nonlinear postflutter LCO characteristics. Rivets that connect the plate to the supporting structure are modeled as local constraint in the in-plane direction, and their effect is investigated. Computations show that the coupling between the cavity acoustic and plate structural modes is necessary for flutter onset in the wind-tunnel conditions. Correlation between computed and measured aerodynamic pressure shows reasonable agreement in amplitude and frequency. Computational results are obtained using Piston Theory and also potential flow aerodynamics. Computed and measured pressure LCO mode shapes are extracted and correlated.
Modern dressings with enzymes for comprehensive management of various etiology wounds
Authors: Ushakov A. A. , Mitish V. A. , Paskhalova Yu. S. , Magomedova S. D. , Borisov I. V. , Orudzheva S. А.
Published: October 2024

The article is a review on the properties of modern Russian wound dressings containing long-acting enzymes immobilized on dialdehyde cellulose (oxidized cellulose). The authors present some clinical observations, as an example of their effective application.
Analysis of wound infections in combat injuries in US (a literature review)
Authors: Borisov I. V. , Mitish V. A. , Paskhalova Yu. S.
Published: October 2024

The article describes problems faced by military doctors in providing medical care to military personnel who had participated in armed conflicts in Iraq and Afghanistan. The authors also discuss results and achievements of multicenter study on consequences of infected wounds TIDOS (The Trauma Infectious Diseases Outcomes Study) of the U.S. Department of Defense (DoD) and the Department of Veterans Affairs (VA) within the program of clinical researches on infectious diseases (USU Infectious Diseases Clinical Research Program – IDCRP). Possible directions for further researches and their importance are also discussed.
Effectiveness of rituximab in the treatment of patients with pemphigus vulgarus
Authors: Karamova Arfenya E. , Znamenskaya Lyudmila F. , Gorodnichev Pavel V. , Krasnova Kristina I. , Plotnikova Evgenia U. , Nefedova Maria A. , Girko Ekaterina V.
Published: October 2024

Pemphigus vulgaris (PV) is an autoimmune disease that affects the mucous membranes and/or skin, characterized by the formation of bubbles of various sizes with a thin flaccid cap and serous contents. Lack of timely treatment can lead to death. Due to the fact that in the Russian Federation the main method of treatment for CAP is the prescription of systemic glucocorticosteroid drugs, which cause a large number of side effects, studies confirming the effectiveness and safety of the use of rituximab in combination with systemic glucocorticosteroid (GCS) are of particular interest. Rituximab is a genetically engineered monoclonal antibody to the CD20 antigen. The mechanism of action is due to the binding of the antibody to the CD20 antigen on B-lymphocytes and the initiation of immunological reactions that mediate the lysis of B-cells, that leads to the elimination of circulating desmoglein-specific IgG(+) B-lymphocytes and contributes to the high effectiveness of rituximab in the treatment of pemphigus. In the treatment PV including rituximab and systemic corticosteroids there is a chance of possible faster reduction of corticosteroids in the daily dose, followed by their complete withdrawal after 3–6 months, that reduces the risk of serious complications developing.
Percepções da enfermagem em cardiologia sobre o clima de segurança em hospital da região norte
Authors: Carvalho Thiago dos Santos , Costa Fabíola Santana de Oliveira , Vilhena Andrezza Ozela de , Santos Silvia Renata Pereira dos , Oliveira Lucas Ferreira de , Scalco Danieli Cristina , Monteiro Francileni Carvalho , Normando Valeria Marques Ferreira , Zaninotto Christielaine Venzel , Lima Anne Caroline Gonçalves
Published: October 2024

Objetivo: Identificar as percepções dos profissionais de enfermagem em cardiologia sobre o clima de segurança do paciente. Métodos: Trata-se de um estudo transversal, descritivo e com abordagem quantitativa desenvolvida com enfermeiros e técnicos de enfermagem da Fundação Hospital de Clínicas Gaspar Vianna (FHCGV). Foi utilizado o instrumento “Safety Attitudes Questionnaire SAQ – Short Form 2006” que é capaz de avaliar o clima de segurança por meio das percepções. Os questionários foram recolhidos e tabulados no Microsoft Excel e em seguida realizada análise exploratória de dados. Resultados: Participaram da pesquisa 67 profissionais da enfermagem de um quantitativo total de 93. O SAQ total correspondeu a 73,60. Os domínios com melhor escore foram “Satisfação do trabalho” com 86,64 e “Clima de trabalho em equipe” com 76,34. Os piores escores foram “Percepção da gerência da unidade e hospital” com 68,53 e 67,5. Conclusão: A análise do clima de segurança de modo geral se mostrou negativa. No entanto, de maneira isolada, alguns domínios se mostraram positivos. Acredita-se que esta pesquisa possa contribuir para o incentivo de novos estudos, visto que os conhecimentos gerados auxiliam no planejamento de ações referentes ao clima institucional.
Differences between Conscious and Unconscious Responses to Stimuli, or W hy Questionnaire Results are Always Wrong
Authors: V.A. Minkin
Published: October 2024

The database of 1002 subjects testing by Blitz Judgment program is analyzed with the known dependence between psychophysiological (unconscious) responses (PPR) for the stimuli of multiple intelligences (MI) and personality vices (PV). The source PPR values proportional to the stimuli relevance for the subject, measured in information-physical quantities — vibra, are normalized similar to conscious response of the subjects. Normalized unconscious response is considered as ideal conscious response. Comparative analysis of PPR correlation for MI and PV stimuli showed high level of correlation (r = 0.8) for source PPR and the low level of correlation (r = 0.24) for normalized PPR. The reasons for the loss of correlation for normalizing PPR values are analyzed. Personal subjectivity in determining PPR zero and sensitivity, occurs during formation of conscious responses to questionnaires, considered as the main reason for the distortion of the dependence between PPR variables. It was concluded that the subjects’ conscious responses to questionnaires are insufficient for the correct assessment of personality traits and unconscious responses are more informative than conscious.
The Accuracy of Measuring Emotions, Psychophysiological Characteristics, Behavioral Parameters and Personality Traits by Video Analytics
Authors: В.А. Акимов , С.С. Диденко , В.А. Минкин
Published: October 2024

Проведено исследование точности и погрешности различных алгоритмов измерения психофизиологических характеристик личности в зависимости от степени сжатия видео файлов и периода наблюдения испытуемого. Проанализировано 106 черно- белых видео файлов (256 градаций серого) изображений лиц испытуемых длительностью 200 секунд, формат видео 640×480, частота кадров 30 Гц. Исследование точности измерений проводилось для алгоритма искусственного интеллекта, диагностирующего COVID-19 и программы Vibraimage PRO с различными настройками быстрого преобразования виброизображения (БПВ), измеряющей поведенческие и психофизиологические параметры человека. В качестве основного критерия точности исследуемых алгоритмов была выбрана относительная погрешность измерений. Построены зависимости относительной погрешности измерений от степени сжатия видео и времени наблюдений за испытуемыми. Даны рекомендации повышения точности измерений психофизиологических и поведенческих параметров для различных характеристик обработки видео изображений лица и головы человека. Разработан новый режим БПВ названный Turbo, позволяющий снизить относительную погрешность и уменьшить время измерения психофизиологических и поведенческих параметров человека за счет увеличения мощности БПВ.

The accuracy and errors of various algorithms for measuring emotions, psychophysiological and behavioral characteristics of a person depending on the video files compression degree and the observation period was studied. The study was conducted on 106 blackand- white video files of subjects’ facial images (256 gray levels), 200 seconds duration, video format 640×480, frame rate 30 Hz. The accuracy was calculated for artificial intelligence algorithm that diagnoses COVID-19 and Vibraimage PRO program for various settings of fast vibraimage transform (FVT) measuring human emotions, behavioral and psychophysiological characteristics. The relative error of measurement was chosen as the main criterion for the accuracy of the algorithms under study. The dependences of the relative error on the degree of video compression and the period of subject observation were plotted. Recommendations are given to improve the accuracy of psychophysiological and behavioral characteristics measurements for different settings of processing video images of human face and head. New FVT Turbo mode has been developed for reducing errors and observation period for measuring emotions, psychophysiological and behavioral parameters of a person by increasing FVT power.
Differences between Conscious and Unconscious Responses to Stimuli, or Why Questionnaire Results are Always Wrong
Authors: В.А. Минкин
Published: October 2024

Анализируется база данных тестирования 1002 испытуемых программой Профайлер+ с известной зависимостью между величинами психофизиологических реакций (ПФР) на стимулы способностей и пороков. Величина ПФР, пропорциональная значимости стимула для испытуемого измеренная в информационно-физических величинах вибрах, нормируется аналогично сознательной реакции испытуемых. Сравнительный анализ корреляции ПФР на стимулы способностей и пороков показал высокий уровень корреляции (r = 0,8) для ненормированной ПФР и низкий уровень корреляции (r = 0,24) для нормированной ПФР. Анализируются причины потери корреляции при нормировании величины ПФР. Основными причинами искажения зависимости между величинами при нормировании ПФР предложено считать персональную субъективность определения нуля и чувствительности, которая происходит при формировании сознательных ответов на вопросы опросников. Искажения исходной ПФР, связанные с искусственным формированием сознательной реакции испытуемых при ответах на вопросы опросника, приводят к необратимой потере информации о связи между исследуемыми величинами. Делается вывод о недостаточности использования сознательной реакции испытуемых при прохождении опросников для корректной оценки характеристик личности и необходимости обработки психофизиологических реакций.

The database of 1002 subjects testing by Blitz Judgment program is analyzed with the known dependence between PPR variables for the stimuli of multiple intelligences (MI) and personality vices (PV). The source PPR values proportional to the stimuli relevance for the subject, measured in information-physical quantities — vibra, are normalized similar to conscious response of the subjects. Comparative analysis of PPR correlation for MI and PV stimuli showed high level of correlation (r = 0.8) for source PPR and the low level of correlation (r = 0.24) for normalized PPR. The reasons for the loss of correlation for normalizing PPR values are analyzed. Personal subjectivity in determining PPR zero and sensitivity, occurs during formation of conscious responses to questionnaires, considered as the main reason for the distortion of the dependence between PPR variables. Distortions of source PPR associated with artificial normalization of subject’s conscious responses to questionnaires leads to irreversible loss of information about the relationship between the studied variables. Concluded that conscious responses of the subjects using questionnaires are insufficient for the correct assessment of personality traits and the processing of psychophysiological responses is required.
The Effect of Regioisomerism on the TADF Properties of Organic Dyes
Authors: Silies Tim , Tombolato Silvia , Stappers Debbie , Doltsinis Nikos , Daniliuc Constantin , Rizzo Fabio
Published: October 2024

The properties of thermally activated delayed fluorescence (TADF) chromophores are highly dependent on the molecular design. The choice of the donor (D) and acceptor (A) group are as important as the choice of the π-linker and the substitution positions. Herein, the influence of regioisomerism through the substitution pattern of 9,9’-spirobi[fluorene] (SBF) on the TADF characteristics is investigated. In our studies, phenothiazine and carbonitrile have been chosen as D and A groups, and their substitution varied among the 2, 2’, 7 and 7’ positions of the spiro core resulting in two pairs of regioisomers. Depending on these changes, the physical properties differ from one to another with changes in emission wavelength maximum, photoluminescence quantum yield (PLQY), fluorescence lifetime and thermal stability. Three of the investigated molecules exhibit TADF properties in solid phase as thin films and crystals.
How to Correct Erroneous Symmetry-Breaking in Coarse-Grained Constant-pH Simulations
Authors: Beyer David , Blanco Pablo M. , Landsgesell Jonas , Kosovan Peter , Holm Christian
Published: October 2024

The constant-pH Monte Carlo method is a popular algorithm to study acid-base equilibria in coarse-grained simulations of charge regulating soft matter systems including weak polyelectrolytes and proteins. However, the method suffers from systematic errors in simulations with explicit ions, which lead to a symmetry-breaking between chemically equivalent implementations of the acid-base equilibrium. Here, we show that this artifact of the algorithm can be corrected a-posteriori by simply shifting the pH-scale. We present two analytical methods as well as a numerical method using Widom insertion to obtain the correction. By numerically investigating various sample systems, we assess the range of validity of the analytical approaches and show that the Widom approach always leads to consistent results, even when the analytical approaches fail. Overall, we provide practical guidelines on how to use constant-pH simulations to avoid systematic errors, including cases where special care is required, such as polyampholytes and proteins.
Research on the Influence of Digital Economy on the Income Gap between Urban and Rural Areas in China
Authors: Fu Limei
Published: October 2024

In recent years, with the rapid advancement of information technology and the widespread proliferation of the Internet, digital technology has been reshaping the value chains of traditional industries and giving rise to entirely new business models and industrial forms. Technologies such as the Internet, big data, and artificial intelligence are being applied across various sectors, while new formats like e-commerce, the sharing economy, and online education are flourishing. These developments have driven new consumption patterns and employment methods. The rapid rise of the digital economy not only boosts production efficiency and economic growth but also influences the income distribution between urban and rural areas to some extent. This paper begins by examining the current state and characteristics of the digital economy and then analyzes its impact on the urban-rural income gap. Additionally, it offers countermeasures and recommendations for narrowing this gap, providing theoretical support for promoting common prosperity.
Struggle for Influence in the Caspian and Central Asian Regions at the Present Stage: Transport Corridors
Authors: Pritchin S. A. , Sobolev M. M. , Ageev A. E.
Published: October 2024

Currently, Central Asia and the Caspian region are experiencing a boom in geopolitical interest from major external players for the second time since gaining independence. In the 90s of the last century, the main area of interest was natural resources, primarily oil and gas, the reserves of which in the region are significant by world standards. The current rapid growth in the activity of major players is concentrated in the transport sector. Difficulties in maritime transportation due to security and environmental issues, and increasing tensions between Russia and the West are pushing for the development of alternative land routes, primarily in Eurasia. This leads to a huge interest in the development of transport corridors through Central Asia and the Caspian Sea, while logistics projects are usually considered by initiators and major players as a tool to strengthen their influence in the region.
BRICS Expansion: New Challenges and Ways to Optimize Cooperation
Authors: Pu G.
Published: October 2024

Today, the multipolar nature of the world is becoming more evident. As the countries gain increasing influence, BRICS members are assuming more responsibility for developing nations, transitioning from merely reacting to international financial challenges to actively shaping the global order.

With the expansion of its membership, BRICS is facing new challenges and opportunities. It has become increasingly important for its member countries to critically reflect on the current international economic and political landscape and analyze their respective positions and strategies for cooperation. In the future, this alliance has the potential to establish itself as a key player in the global South, serving as a significant platform for large-scale governance.
The Perception of the Special Military Operation in the Modern Domestic Student Environment and the Tasks of the Russian Government for the Patriotic Education of Generation Z
Authors: Soboleva E. O.
Published: October 2024

The article discusses the analysis of Russian students’ attitudes towards the special military operation. Specifically, it attempts to understand and explain why there is a rather cool perception of the situation among young people, as well as the desire to distance oneself from the mobilization topic and take a wait-and-see approach to the issue. At the same time, the author connects the analysis with the problems of modern youth socialization, as well as with the insufficient effectiveness of government agencies’ propaganda efforts with students. Options for improving such activities are suggested in order to increase student involvement in patriotic activities, including promoting their own initiatives.
The Influence of the Dissemination of Fake Information on Social Networks on the Minds of Student Youth
Authors: Voinich K. S.
Published: October 2024

The article discusses the issues of misinformation dissemination on social media and its impact on student views. Based on the analysis of current approaches to studying information influence on public opinion, the main trends in shaping the consciousness of the younger generation have been identified. As a result of this study, it has been revealed that higher education institutions are not sufficiently involved in counteracting fake information on the internet and promoting digital literacy among young people. In response to this, the author has developed several practical recommendations.
echnological Sovereignty as a Stimulus for the Development of Russian Science
Authors: Kolomiytsev S. Yu.
Published: October 2024

There is a sharp change in economic and production relations between countries in the modern world, and integration processes are replaced in many cases by isolation, “islandization” and sovereignization. Under these conditions, it seems relevant to analyze the most important indicators of Russian science and consider its future prospects. The dynamics of the number of scientists, the number of journals, the salaries of scientists and money allocated by the government for scientific research were chosen as the main indicators. Having examined these indicators and compared them with the indicators of other countries, the conclusions presented in the article have been drawn. The author hopes that the findings could contribute to the further competent management of Russian science and will ensure the stable development of Russia in new economic and political conditions.