bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of the protein-, L-tryptophan-, carbohydrate-, oil-rich diets on the levels of melatonin, oxidative stress, antioxidative agents, and vital digestive enzymes in the gut of early juvenile (EJv) and late juvenile (LJv) carp (Catla catla)
Authors: Yasmin Farha , Sutradhar Sona , Roy Arun , Sarkar Russel , Mukherjee Sourav
Published: March 2023

The present study was performed with the gut tissue of early juvenile (EJv) (body weight range between 40-70g) and late juvenile (LJv) (body weight range between 200-300g) carp, Catla catla, to address three queries. First, to search for any variations in the levels of gut melatonin, oxidative stress levels, its management, and vital digestive enzymes between the EJv and LJv carps. Second, to understand the response of dietary supply of protein-, L-tryptophan-, carbohydrate-, and oil-rich diet on the levels of melatonin concentration, oxidative stress, antioxidative agents, and activity of major digestive enzymes in the gut. Third, to comprehend the role of gut melatonin in managing oxidative stress and modulating the digestive capacity. Data analysis revealed that gut melatonin concentration is higher in EJv carp and lower in LJv carp, while feeding intensity was the reverse. The L-tryptophan and protein-rich diets exhibited stimulatory but different responses to gut melatonin, amount of residual gut content and feeding intensity between the EJv and LJv carps. Substantial evidence was recorded on the role of gut melatonin in regulating stress, levels of antioxidative agents, and vital digestive enzymes, particularly in protein and microbial digestion. Nonetheless, the current study reports for the first time that the nature of gut melatonin synthesis, feeding intensity, generation of oxidative stress, defense by different antioxidants, and digestive capacity vary in LJv carp from its EJv stage. Further, such variations may also be modulated by the dietary components of fish feeds, particularly by the protein or L-tryptophan enrich fraction.
Pre- and Post-operative Variation of Neutrophil-to-lymphocyte Ratio (NLR) Predict Prognosis factor in Rectal Cancer Patients with Radical Primary Tumor Resection: a monoinstitutional retrospective study
Authors: Li Yangcheng , Li Jing , Cui XiaoPeng , Chen Tie , Jiang XiaoHui
Published: March 2023

Purpose
The pre- and post-operative variation of neutrophil to lymphocyte ratio is reportedly related to postoperative prognosis. This research was undertaken to evaluate the potential of ΔNLR= (ΔNeutrophil to lymphocyte ratio = postoperative extreme neutrophil to lymphocyte ratio - preoperative neutrophil to lymphocyte ratio) to predict the prognosis based on its relationship with overall survival and relapse-free survival in patients with rectal cancer treated with radical operation.
Methods
This study was single institution retrospective study that conducted in colorectal surgery at a tertiary teaching hospital. The 584 patients with pathologically confirmed rectal cancer and treated with primary tumor resection between 2012 and 2014 in a single university-affiliated tertiary academic hospital were involved. To assessment the veracity of ΔNLR for rectal carcinoma prediction, a receiver operating characteristic curve was plotted. Patients were divided into two groups, high and low ΔNLR, according to the optimal cutoff value. The proportional risk regression model was performed univariate and multivariate analysis for rectal carcinoma prediction.
Results
Multivariate analysis showed that a high pretreated serum carcinoembryonic antigen ( p = 0.005), Tumor stage ( III VS I( p < 0.001), II VS I( p = 0.006)), chemotherapy ( p < 0.001) and ΔNLR ( p = 0.002) was an independent prognostic factor for poor overall survival.
Conclusion
Our research shows that the ΔNLR might be a prognostic marker in RC patients with operative treatment.
Clinical attire preference among patients in military healthcare facilities in Kuwait
Authors: Albagdady Mohammad , Alotaibi Hazza , Sadek Ali Ahmad , Hands Joanne , Alali Ahmad , Alsabah Abdullah Meshal
Published: March 2023

Objectives
Military healthcare professionals often consult patients while wearing their full military uniforms, which may affect patients’ clinical experience. This study aims to understand patients’ opinion concerning clinicians’ attire with regard to patients’ preference, ease in declaring personal or private information, comfort in asking for further information or raising concerns, and confidence in maintaining privacy and confidentiality in a military setting.
Methods
Patients attending outpatient clinics in two military medical facilities in Kuwait were asked to complete a questionnaire regarding their preference for clinician attire and any effect on their comfort or confidence in the clinicians. The study took place in 2021.
Results
The overall response rate was 94.6% (n = 937). Most participants were neutral regarding all statements. However, female participants preferred their doctors to be in military uniforms in comparison with males (P = 0.000). Non-Kuwaiti participants felt more comfortable sharing private/personal information and asking for clarification or raising concerns with a doctor in military uniform (p = 0.007). Civilian participants also preferred doctors in military uniform (p = 0.000). Officers preferred their doctor to be in military uniform (p = 0.014), whereas non-commissioned officers preferred their doctor to be in civilian attire (p = 0.000).
Conclusion
Patients visiting military medical facilities do not prefer a certain attire, and attire does not influence their perception of the physicians’ competence. This may lead us to conclude that doctors’ attire, regardless of being civilian or military, may not be the most concerning factor regarding the patient’s confidence and comfort and that the doctor-patient relationship is more vital. Therefore, further investigation of the psychological impact of doctor’s attire is highly recommended.
Petrography and Diagenesis of Neoproterozoic Bhander Sandstones of Bundi-Indergarh area, Vindhyan Supergroup, Southeastern Rajasthan, India: Implication for Provenance and Reservoir characteristics
Authors: Ayaz Tahreer , Hasan Mujeebul , Khan Abdullah
Published: March 2023

The Neoproterozoic Bhander Group, the youngest and most widely distributed group of Upper Vindhyans, consists of about 1000m thick succession of sandstone, shale, and limestone. Petrographic investigations reveal that the Bhander Sandstones are mineralogically mature and classified as quartzarenite and sublitharenite type which is composed of varieties of quartz with ultra-scarcity of feldspar, lithic fragments, micas, and heavy minerals. Average framework composition of the Lower Bhander Sandstone is Qt98.68F0.10L1.22 and Upper Bhander Sandstone is Qt95.92F0.12L3.96. Quartz is a more abundant mineral, as shown by X-ray Diffraction Analysis. Petrofacies reveal that the Bhander Sandstones were derived mainly from the source rocks of a craton interior setting with a minor quartzose recycled sedimentary source material. A scarcity of feldspar and rock fragments suggests intense chemical weathering in a warm and humid paleoclimate. Mechanical compaction, cements, authigenic clays, and dissolution and modification of unstable clastic grains are the major diagenetic components identified based on the framework grain-cement relationships. Kaolinite and silica (quartz) overgrowth are found as pore-filling and lining cements. Compaction was more effective than cementation in affecting primary porosity. Cementation decreased porosity and permeability drastically. Kaolinite fills pore spaces, reducing the sandstone's porosity and permeability. Secondary porosity developed as a result of partial to complete feldspar dissolution. The diagenetic signatures observed in the Bhander Sandstones are suggestive of deep burial. The reservoir quality of the studied sandstones is degraded by authigenic clay minerals and cementations, but enhanced by alteration and dissolution of unstable grains.
An Ensemble-based Predictive Model for Examine Chronic Kidney Disease
Authors: Nagalpara Sirajbhai , Patel Bhavesh
Published: March 2023

Chronic Kidney Disease (CKD) is a chronic ailment that involves a gradual decline in kidney function over time and lose their function over time. The focus of the research was to determine the most suitable classification algorithm for the diagnosis of CKD based on its classification report and performance factors. One approach to enhancing the accuracy of predictions is to combine multiple models such as Random Forest and Adaboost classifier were analyzed instead of relying on a single model. To put it another way, using an ensemble of models can lead to better predictive performance compared to using a single model alone. The results of the experiment showed that the stacking algorithms performed better than the other algorithms, producing an accuracy rate of 100.00%.
ViWOZ: A Multi-Domain Task-Oriented DialogueSystems Dataset For Low-resource Language
Authors: Van Phi Nguyen , Hoang Tung Cao , Manh Dung Nguyen , Khanh Huyen Bui , Minh Quan Nguyen , Tran Long Quoc
Published: March 2023

Most of the current task-oriented dialogue systems (ToD), despite having interest-ing results, are designed for a handful of languages such as Chinese and English.Therefore, their performance in low-resource languages is still a significant prob-lem due to the absence of a standard dataset and evaluation policy. To addressthis problem, we proposed ViWOZ, a fully-annotated Vietnamese task-orienteddialogue dataset. ViWOZ is the first multi-turn, multi-domain, task-orienteddataset in Vietnamese, a low-resource language. The dataset consists of 5,000dialogues in total, including 60,946 fully annotated utterances. Furthermore, weprovide a comprehensive benchmark for both modular and end-to-end models inlow-resource language scenarios. With those characteristics, the ViWOZ datasetenables future studies on the construction of multilingual task-oriented dialoguesystems.
Non-separation method-based global stability criteria for Takagi-Sugeno fuzzy quaternion-valued BAM delayed neural networks using quaternion-valued auxiliary function-based integral inequality
Authors: Ramalingam Sriraman , Kwon Oh-Min
Published: March 2023

This paper examines the global asymptotic stability of Takagi-Sugeno fuzzy quaternion-valued BAM neural networks with discrete, distributed and leakage delays using non-separation method. By applying Takagi-Sugeno fuzzy models , we first consider a general form of Takagi-Sugeno fuzzy quaternion-valued BAM neural networks with time delays. Then, we apply the Cauchy-Schwarz algorithm and homeomorphism principle in order to establish the existence and uniqueness of the equilibrium point. By using appropriate Lyapunov-Krasovskii functionals and quaternion-valued auxiliary function-based integral inequality, we derive new delay-dependent global asymptotic stability conditions for the considered neural networks. Furthermore, we present our results in terms of quaternion-valued linear matrix inequalities that can be solved in the MATLAB YALMIP toolbox. To demonstrate the validity of the theoretical analysis, we provide two numerical evaluations with simulations.
Reinforcement Performance of the Bolted Rock Mass with a Weak Interlayer Under Constant Lateral Stiffness Boundary Condition
Authors: Ding Shuxue , Jiang Peilin , Jing Hongwen , Qiao Jing , Guo Jiaqi
Published: March 2023

The widespread existence of weak interlayer poses a serious threat to the stability of roadway surrounding rock under constant stiffness restraint boundary condition in lateral direction (axial direction of roadway) and the rock bolt is widely used to reinforce the surrounding rock of roadway. So, in this paper, the reinforcement performance of the bolted rock mass with a weak interlayer was investigated under constant lateral stiffness (CLS) boundary condition. The research results indicated that the peak strength and elasticity modulus of the samples exponentially increase with the increasing of bolt pretension force and density. Two parameters Rp and RE were put forward to quantitatively describe the reinforcement effect of bolt pretension force and density on the peak strength and elasticity modulus of the samples. Under CLS boundary condition, the lateral direction of the samples experienced loading-unloading and expansion - compaction deformation periods during the whole triaxial compression process. The mechanism for the transformation of expansion - to - compaction was explained. Two new failure modes of the samples were observed and analyzed in detail, and were found them different from those of the bolted jointed rock mass and bedded rock mass.
BRAF V600E genetic testing should be recommended for Bethesda III or V thyroid nodules based on fine-needle aspiration
Authors: Lu Yiran , Guo Xinghong , Yang Mengmeng , Wang Kewei , Cao Guanglei , Liu Yan , Hou Xinguo , Chen Li , Liang Kai
Published: March 2023

Purpose
The preoperative diagnosis of thyroid nodules now routinely includes BRAFV600E genetic testing in most provincial and municipal hospitals in China. This study identified the most suitable patients of thyroid nodule for BRAFV600E genetic testing.
Methods
We retrospectively collected data of patients from the Hospital Information System that had undergone fine needle aspiration biopsy (FNAB) from May 2019 to December 2021. Data of FNAB, BRAFV600E genetic testing, and post-surgical pathological diagnosis were collected.
Results
A total of 12,392 patients were included in this study. Among them, 7,010 patients underwent solely FNAB, while 5,382 patients had both FNAB and BRAFV600E genetic testing. In the FNAB group, 2,065 thyroid nodules were surgically removed, with a 93.12% malignancy rate. In the FNAB + BRAF group, 2,005 nodules were dissected, and the malignancy rate was 98.20%. However, it was evident that in the subgroups, the combination of FNAB and BRAFV600E genetic testing only benefited Bethesda III (p < 0.001) and V (p = 0.001) nodules.
Conclusion
Overall, the combination of FNAB with BRAFV600E genetic testing significantly improved the malignancy rate of surgical thyroid nodes at our hospital when compared to FNAB alone. The subgroup analysis showed that BRAFV600E genetic testing only benefited Bethesda III and V nodules. These findings provide a clinical reference for rationally selecting the most suitable population for BRAFV600E genetic testing.
An Analytical Study of the Effect of Gravity on Electronic Wavefunctions in Oxygen
Authors: Saraswat Rushil
Published: March 2023

We can determine the presence of oxygen in the sun by observing its absorption spectrum. However, no single wavelength observed in the oxygen spectrum of the sun directly corresponds to the Ritz wavelength of either the oxygen atom or the oxygen molecule. To account for this inconsistency, the study hypothesizes that the shells of the oxygen atom expand or compress under the presence of gravity, and it causes the change of difference in energy levels. To verify the hypothesis, the study assumes the shells in the atom to be different levels of a modified version of an infinite potential well. The relative distance between two shells of atoms present on the earth and the sun can be worked out by comparing the energies of the modified infinite potential wells. The study finds that the ratio of distances between the atoms present on the earth and the sun is not same, hence, verifying the hypothesis. To further verify the hypothesis, analysis of spectrums of more elements under the influence of a large gravitational field and with significant screening effects is required.
An Extensive Integrative Literature Review of Quality of Experience in Virtual Reality
Authors: Zheleva Aleksandra , Durnez Wouter , De Marez Lieven , Talsma Durk , Bombeke Klaas
Published: March 2023

The development and rapid adoption of virtual reality (VR) have brought with it the need to redefine the concept of quality of user experience (QoE). To date, QoE models for VR have provided us with a narrow view of the concept, traditionally operating under the umbrella of a single discipline (e.g., psychology) or a specific feature of the user experience (e.g., presence). Moreover, literature reviews on the topic have focused on academic articles disregarding the constant technological updates reflected in industry reports. Addressing these gaps, the current study adopted a rigorous, integrative literature review approach. The results of 729 sources were analysed to outline and describe 252 factors divided into four main branches (i.e. user, system, context and content). Finally, a comprehensive multidisciplinary model was created based on representative academic and industry sources from the fields of psychology, communication sciences, ergonomics, computer science and technological innovation. Notably, an interactive dashboard that outlined in detail the facets of the model was developed. The dashboard presents scholars and developers with a practical tool that aids the design of future experiments and the development of VR products. Ultimately, the extensive scope and laborious state-of-the-art methodology of the current paper present significant value to academia and industry alike.
Is the age of menarche influenced by a girl's socioeconomic status?
Authors: BIRIR REYAD , Berir Aymen Eltom Omer , Eljack Mohammed Mahmmoud Fadelallah , Alfaki Eltayeb Mohamed , Altayeb Ehab Algaili kamal aldeen , hamid Abobaker algaili omer , Alqurashi Siddiga Berair Ahmed
Published: March 2023

Background
Menarche is a key indicator of puberty and is influenced by a variety of variables, including socioeconomic status and their residence. To provide health services and menstrual health education to schoolgirls, health policymakers must be aware of the menarche age. Here in we aimed to investigate the timing of menarche in secondary school girls and its associations with socioeconomic status and body mass index.
Methods
A cross-sectional study enrolled 130 girls carried out from January to march 2023 in secondary schools in Shabasha City, White Nile State, Sudan. Structured questionnaires were used to gather the personal information from the girls and parents, age at menarche, and factors influencing age at menarche, height, and weight.
Results
The mean age of girls was 16.5 ± 1 years while the mean age of menarche was found to be 13.6 ± 1.3 years, and the majority of the girls had menarche age of 14 years 44(33.8%) and 13 years 42(32.3%). Mothers (n = 86; 66.2%), sisters or friends (n = 84; 64.6%), and teachers (n = 81; 62.3%) were the main advisors. Also, examinations were the main stressor in 12(9.2%) girls. The age of menarche was found to be negatively correlated with BMI (r= -0.365; P. value = 0.027), and underweight girls had a later age of menarche (14.81.4 years; P. value = 0.000). Furthermore, girls with low socioeconomic status had menarche at a later age (14.61.3 years). Menarche occurred later in girls who lived with their father alone (14.31.6 years) and with their mother alone (140.5 years). The age of menarche had no effect on parental education, family size, or stressors (P value > 0.05).
Conclusion
The age of menarche among schoolgirls was found to be relatively similar to that reported in Sudan and other countries in the region. It was significantly related to the girls' BMI, socioeconomic status, and the types of residents.
Analiza antifeminizma u djelu filozofkinje Gordane Bosanac
Authors: Adamović Mirjana
Published: March 2023

U ovome se radu raspravlja o klasifikaciji antifeminizma iznesenoj u knjizi Visoko čelo filozofkinje Gordane Bosanac. U toj knjizi, u potpunosti posvećenoj temi antifeminizma, Gordana Bosanac ukazuje na povezanost feminizma i antifeminizma, pri čemu antifeminizam određuje »konzervativnom recepcijom feminističkih vrijednosti i reakciju u osnovi primitivne svijesti«. Feminizam određuje humanističkim i najširim demokratskim pokretom koji počiva na toleranciji, ali i svjetskim idejama koje su usmjerene k miru i pravu na život prirode. Klasifikacija antifeminizma u ovom radu kontekstualizirana je s obzirom na pojavu novih vrsta antifeminizama i njegovih oblika u suvremenim društvima, a posebno u svijetu interneta. U radu se zaključuje da je klasifikacija izvanredno vrijedan i poticajan okvir za daljnja istraživanja ne samo u teorijskom nego i u empirijskom pogledu. Klasifikaciju antifeminizma stvarnost nije demantirala, ona je ostala otvorena za nove pojave i veze koje antifeminizam ima s idejama nove desnice i desnim društvenim pokretima.
Hoće li filozofkinja uspjeti misliti?
Authors: Čakardić Ankica
Published: March 2023

U ovom ćemo radu, polazeći implicitno od neuralgične epistemološke točke koju je izazvalo pitanje Kostasa Axelosa postavljeno Gordani Bosanac: »Hoće li žena uspjeti misliti?«, analizirati Drugi spol (Le Deuxième sexe, 1949.) Simone de Beauvoir, ne bismo li namjerno rastvorili ironiju Axelosova pitanja čitanjem i razgovorom s tekstom jedne od najvažnijih filozofkinja u povijesti filozofije. Drugi spol interpretirat ćemo kao izvještaj o fenomenologiji odnosa orodnjenoga Ja i rodno obilježenoga svijeta, u kojem društveni ideali femininoga oblikuju iskustvo ženskoga Ja i procese postajanja ženom. Rad je strukturiran u tri sekcije. Nakon uvodnih bilješki, u prvoj sekciji, naslovljenoj kao »Ad feminam kritike i kontroverze«, prikazat ćemo tek nekolicinu paradigmatskih primjera kontroverzi i negativnih reakcija koje su uslijedile nakon publiciranja Drugoga spola. U »Fenomenologiji roda«, drugoj i ključnoj sekciji rada, posvetit ćemo pažnju izvornom čitanju Drugoga spola, mapirajući u knjizi egzistencijalističko-fenomenološke teze o rodu. Konačno, u zaključnim notama rada, izradit ćemo tek skicu nekolicine recentnijih čitanja Drugoga spola ne bismo li ukazali na aktualne i vrlo angažirane afirmacije i nadopune ideja koje je Simone de Beauvoir najavila tim filozofskim klasikom.
»Odgoj i obrazovanje kao fundamentalna društvena djelatnost«
Authors: Krznar Tomislav
Published: March 2023

U ovom radu nastojimo prikazati probleme odgoja i obrazovanja kako ih je vidjela hrvatska filozofkinja Gordana Bosanac (Varaždin, 1936. – Zagreb, 2019.). Iako ovi problemi ne ulaze u najuži krug njenih interesa, autorica se njima intenzivno bavila tijekom cijelog života i ostavila značajan trag u promišljanju ključnih aspekata i dosega problematike koju nalazimo u okrilju filozofije odgoja. Glavna teza rada sljedeća je: misao G. Bosanac i danas je vrlo aktualna, i to najmanje u dvije vizure. Prvoj, kao kronologija različitih intervencija u sustav odgoja i obrazovanja, i drugoj, kao prikaz inovativnih promišljanja o odgoju i obrazovanju koja u središte nastojanja stavljaju čovjeka i njegove/njezine misaone mogućnosti, a ne neku društvenu ili proizvodnu svrhu ili potrebu. U tom pogledu rad zamišljamo kao prikaz, uz temeljne životopisne podatke, nekoliko misaonih sklopova G. Bosanac. Prvo ćemo tematizirati opće sadržaje problematike odgoja i obrazovanja, upućujući posebno na odnos onog individualnog i onog društvenog u odgoju i obrazovanju. Nakon toga, promislit ćemo, na tragu misli G. Bosanac, problematiku rada, s posebnim nastojanjem oko promišljanja sadržaja rada u odgoju i obrazovanju. U trećem dijelu, promislit ćemo, uz značajno oslanjanje na misao G. Bosanac, problematiku ideologije i njen negativan utjecaj na sustav odgoja i obrazovanja, te posebno, na dionike tog sustava. U konačnici, ili kao prvotan zadatak rada, nastojimo dati odgovor na pitanje, zašto su baš odgoj i obrazovanje fundamentalne društvene djelatnosti?
S onu stranu subjektivnosti – priče kao lokucija jezika
Authors: Mićić Nemanja
Published: March 2023

U ovom radu autor nastoji pokazati na koji način različite implikacije poststrukturalističkih teorija, u vezi s problematikom pojma subjektivnosti, mogu biti tretirane tzv. »narativnom metodom«. Spomenuta metoda profilira se kroz poststrukturalistički teorijski okvir, unutar kojega se inzistira na eluzivnome karakteru instance subjektivnosti. To je iskorišteno da se skrene pažnja na područje jezika, kao odlučujuće za kreiranje svakoga govora o strukturi stvarnosti. Taj je govor prepoznat kao, u bitnome, pripovjednoga karaktera, što znači da je priča uzeta kao osnovna jedinica jezika. Narativnom metodom jednako je moguće intervenirati i na polju koje omogućava njegovo kristaliziranje. Stoga, ovaj rad polazi od analiza tekstova Gayatri Chakravorty Spivak, Roberta Calassa i Michela Foucaulta, tumačeći ih iz vizure filozofije priča nastale prvenstveno uvidima Wilhelma Schappa. Ispostavit će se da te pripovijesti približavaju jezik njegovom autentičnijem razumijevanju, kao čistom mnoštvu kontingentnih priča. Za to nam je neophodna primjena narativne metode.
Presence of symptoms caused by parasitic species described in grapevine herbaria from Georgia, Spain and the United Kingdom
Authors: Lara Miguel , Morales Ramón , Alvar Ocete Carlos , Ocete Rafael , Kikvadze Maia , Hidalgo Juanjo , Maghradze David
Published: March 2023

The present paper focuses on the presence of symptoms caused by parasitic species in samples of Eurasian grapevine (Vitis vinifera L.) belonging to different herbaria from , and the . In the Spanish case herbaria were collected by Clemente at the beginning of the 19th century and preserved at the Royal Botanical Garden of Madrid. This material was used as the basis for the publication in 1807 of the famous book “Ensayo sobre las variedades de la vid común que vegetan en Andalucía” (Essay on the varieties of common grapevine that vegetate in ). The Georgian herbaria originated from three institutions: National Museum of Georgia, National Herbarium of Georgia and . The time period of the Georgian herbaria dates from mid-19th century. The herbaria came from Kew Royal Botanical Gardens and contain samples dated as of 1843. According to observations, in the Spanish herbarium, 98 samples out of 185 show erinea, symptoms caused by Colomerus vitis (Pagenstecher) (Acari, Eryophiidae), from a total of 185 samples there. Meanwhile in other herbaria its presence was detected in 3 samples, which also showed spots caused by powdery mildew, Erysiphe necator (Schweinitz). Symptoms caused by downy mildew, Plasmopara viticola Berl. & De Toni, were only detected in one sample collected in . Results attest the frequent presence of this monophagous mite pest on Southern Spanish cultivars and wild exemplars for more than two centuries.
Diálogos sobre la diversidad sexual y de género en el contexto de la Red Noreste de Enseñanza de Postgrado en Educación (RENOEN)
Authors: Dias Alfrancio Ferreira , Silva Ivanderson Pereira da , Amar Víctor , Brazão José Paulo Gomes
Published: March 2023

Este ensayo describe alternativas señaladas para la superación de las desigualdades de género en la enseñanza y la Educación para las diversas expresiones del machismo en la sociedad contemporánea, así como para las expresiones del sexismo en los planes de estudio de los cursos de formación de profesores. Socializa apuntes teóricos y metodológicos de estos intercambios entre investigadores comprometidos con la construcción de una sociedad igualitaria a través de la enseñanza y la Educación. En un primer momento, se presentaron las tensiones por las opresiones estructurales de la sociedad, entre las cuales, destacamos las desigualdades de género y sus formas de reproducción a través de la enseñanza y la Educación. En un segundo momento, discutimos formas sofisticadas de expresión del machismo en la actualidad, así como alternativas para la construcción de un horizonte libre de jerarquizaciones de los cuerpos. Por último, se evaluaron diferentes formas de reproducción del sexismo en los planes de estudio de los cursos de formación de profesores.
Therapeutic and Diagnostic Agents based on Bioactive Endogenous
and Exogenous Coordination Compounds
Authors: Kostova Irena
Published: March 2023

Metal-based coordination compounds have very special place in bioinorganic
chemistry because of their different structural arrangements and significant application in
medicine. Rapid progress in this field increasingly enables the targeted design and
synthesis of metal-based pharmaceutical agents that fulfill valuable roles as diagnostic or
therapeutic agents. Various coordination compounds have important biological functions,
both those initially present in the body (endogenous) and those entering the organisms
from the external environment (exogenous): vitamins, drugs, toxic substances, etc. In the
therapeutic and diagnostic practice, both the essential for all living organisms and the
trace metals are used in metal-containing coordination compounds. In the current review,
the most important functional biologically active compounds were classified group by
group according to the position of the elements in the periodic table.
Endoplasmic Reticulum as a Therapeutic Target in Cancer: Is there
a Role for Flavonoids?
Authors: Aghakhani Ava , Hezave Mehrnoush Baradaran , Rasouli Asma , Saberi Rounkian Masoumeh , Soleimanlou Fatemeh , Alhani Arian , Sabet Eqlidi Nasim , Pirani Maryam , Mehrtabar Saba , Zerangian Nasibeh , Pormehr-Yabandeh Asiyeh , Keylani Kimia , Tizro Neda , Deravi Niloofar
Published: March 2023

Flavonoids are classified into subclasses of polyphenols, a multipurpose
category of natural compounds which comprises secondary metabolites extracted from
vascular plants and are plentiful in the human diet. Although the details of flavonoid
mechanisms are still not realized correctly, they are generally regarded as antimicrobial,
anti-fungal, anti-inflammatory, anti-oxidative; anti-mutagenic; anti-neoplastic;
anti-aging; anti-diabetic, cardio-protective, etc. The anti-cancer properties of flavonoids
are evident in functions such as prevention of proliferation, metastasis, invasion, inflammation
and activation of cell death. Tumors growth and enlargement expose cells to
acidosis, hypoxia, and lack of nutrients which result in endoplasmic reticulum (ER)
stress; it triggers the unfolded protein response (UPR), which reclaims homeostasis or
activates autophagy. Steady stimulation of ER stress can switch autophagy to apoptosis.
The connection between ER stress and cancer, in association with UPR, has been
explained. The signals provided by UPR can activate or inhibit anti-apoptotic or apoptotic
pathways depending on the period and grade of ER stress. In this review, we will
peruse the link between flavonoids and their impact on the endoplasmic reticulum in
association with cancer therapy.
An Overview of CDK Enzyme Inhibitors in Cancer Therapy
Authors: Mounika Peddaguravagari , Gurupadayya Bannimath , Kumar Honnavalli Yogish , Namitha Bannimath
Published: March 2023

The ability to address the cell cycle in cancer therapy brings up new medication development
possibilities. Cyclin-dependent kinases are a group of proteins that control the progression of the
cell cycle. The CDK/cyclin complexes are activated when specific CDK sites are phosphorylated. Because
of their non-selectivity and severe toxicity, most first-generation CDK inhibitors (also known as
pan-CDK inhibitors) have not been authorized for clinical usage. Despite this, significant progress has
been made in allowing pan-CDK inhibitors to be employed in clinical settings. Pan-CDK inhibitors'
toxicity and side effects have been lowered in recent years because of the introduction of combination
therapy techniques. As a result of this, pan-CDK inhibitors have regained a lot of clinical potential as a
combination therapy approach. The CDK family members have been introduced in this overview, and
their important roles in cell cycle control have been discussed. Then, we have described the current
state of CDK inhibitor research, with a focus on inhibitors other than CDK4/6. We have mentioned
first-generation pan-CDKIs, flavopiridol and roscovitine, as well as second-generation CDKIs, dinaciclib,
P276-00, AT7519, TG02, roniciclib, and RGB-286638, based on their research phases, clinical
trials, and cancer targeting. CDKIs are CDK4/6, CDK7, CDK9, and CDK12 inhibitors. Finally, we
have looked into the efficacy of CDK inhibitors and PD1/PDL1 antibodies when used together, which
could lead to the development of a viable cancer treatment strategy
Phyto Pharmaceutical Advances on Black Turmeric as a Functional Herb
Authors: Kaur Simranjeet , Chauhan Pratik N. , Junaid Ul Hamid  , Kaur Simran , Sharma Yashika
Published: March 2023

Herbal medicine is one of humanity's oldest professions, and herbal medicine's therapeutic
efficacy has been recognised since the dawn of time. In many parts of India, herbal treatments
have been found to be effective in the treatment of malaria, diarrhoea, jaundice, diabetes,
cough, fever, snakebite, miscarriages, and gonorrhoea. Curcuma caesia is a perennial herb with
bluish-black rhizomes that is native to Northeast and Central India. In antioxidant, antiinflammatory,
and human tumour cell proliferation, inhibitory effects of the rhizomes of indigenous
Curcuma caesia were investigated in this work. According to Research, Inc., the global
curcumin market was worth USD 46.6 million, with North America being the largest regional
market and India being one of the largest curcumin producers. With a revenue-based compound
yearly growth rate (CAGR) of 14.8% throughout the projection period, Europe is predicted to be
the fastest-growing region, with the global market. Because of expanding scientific talent and a
large network of biotechnology and food chemistry applications, curcumin quality and quantity
are projected to improve in the future. The study emphasizes the importance of using the bioactive
components of curcuma caesia in nanotechnology, liposomes, niosomes, micelles, and cyclodextrin.
Potential Value of the Stretched Exponential and Fractional Order Calculus
Model in Discriminating Between Hepatocellular Carcinoma and Intrahepatic
Cholangiocarcinoma: An Animal Experiment of Orthotopic Xenograft Nude
Mice
Authors: Xie Jinhuan , Li Chenhui , Chen Yidi , Zhang Huiting , Lin Huashan , Yang Guang , Long Liling
Published: March 2023

Background:

In clinical practice, Preoperative differentiation between hepatocellular carcinoma and intrahepatic cholangiocarcinoma is challenging but critical for treatment decisions.

Objective:

This study investigated the discriminatory power of the stretched-exponential model and fractional-order calculus model parameters for hepatocellular carcinoma versus intrahepatic cholangiocarcinoma in orthotopic xenograft nude mice.

Methods:

Prototype orthotopic xenograft models of hepatocellular carcinoma and intrahepatic cholangiocarcinoma were developed using 20 nude mice divided into two groups and separately transplanted with MHCC97H and HUCCT1 cells. Readout-segmented diffusion-weighted imaging with multiple b-values (0–2000 s/mm2) was obtained using a 3.0-T magnetic resonance imaging scanner. The apparent diffusion coefficient was calculated using the mono-exponential model. The distributed diffusion coefficient and intravoxel water molecular diffusion heterogeneity (α) were calculated using the stretched-exponential model. The diffusion coefficient (D), fractional-order derivative in space (β), and spatial parameter (μ) were calculated using the fractional-order calculus model. The liver and tumor specimens of nude mice were immunostained after euthanasia to clarify the liver cancer type. Differences in diffusion-related parameters between the groups were evaluated using Mann–Whitney U-test and univariate logistic analysis. Receiver operating characteristic curves were used to assess the diagnostic efficacy of each parameter. P<0.05 was deemed significant.

Results:

α, D, and β were significant discriminators between the groups. The area under the curve for these three variables was 0.890, 0.830, and 0.870, respectively, with cutoff values of 0.491, 0.435, and 0.782, respectively.

Conclusion:

The stretched-exponential model parameters α and the fractional-order calculus model parameters D and β showed high diagnostic efficacy in discriminating intrahepatic cholangiocarcinoma from hepatocellular carcinoma in orthotopic xenograft nude mouse models.
LCMS Determination and Cytotoxicity of Abrus precatorius on L6 and SK-N-MC
Cell Lines
Authors: Naduchamy Krishna Prabha , Parthasarathy Varadarajan
Published: March 2023

Objective:

The present study aimed to investigate the cytotoxic effect of various extracts derived from Abrus
precatorius Linn. leaves on rat L6 and human SK-N-MC neuroblastoma cell lines and determine the secondary metabolites
responsible for the cytotoxicity of Abrus precatorius.

Methods:

Successive solvent extraction of A. precatorius leaves was carried out using the Soxhlet apparatus with solvents
such as petroleum ether, chloroform, ethyl acetate, and ethanol. HPTLC fingerprinting and LC-MS studies were
performed to assess the presence of secondary metabolites, such as flavonoids and phenols, in the ethyl acetate extract.
Furthermore, the cytotoxic effect of extracts was tested on rat skeletal muscle cell line L6 and human neuroblastoma
cell line SK-N-MC using MTT assay.

Results:

The total phenolic content of ethyl acetate and ethanol extracts of A. precatorius were 72.67 and 60.73 mg,
respectively, of GAE/g dry weight of the extract. The total flavonoid content of ethyl acetate and ethanol extract of A.
precatorius were 107.33 and 40.66 mg of Quercetin equivalents/g dry weight of the extract. LCMS analysis demonstrated
that the flavonoids in specific Naringenin, Diosmetin, Glycitin, and Genistein might play a prominent role in the
cytotoxicity of A. precatorius. The cytotoxicity study revealed that the extracts of A. precatorius were non-toxic to rat L6
myotubes, and the IC50 values of the various extracts, such as APPE, APCH, APEA, and APET, were >100 μg/ml. The
extracts exhibited cytotoxic activity against human neuroblastoma SK-N-MC cells, and the IC50 values of APPE, APCH,
APEA, APET, and the standard drug “Cisplatin” were >100, >100, 64.88, >100, and 3.72 μg/ml, respectively.

Conclusion:

It was concluded from the study that the extracts of Abrus precatorius were cytotoxic to neuroblastoma
cell lines but non-toxic to normal cell lines. HPTLC and LC-MS studies confirmed that flavonoids in the ethyl acetate
extract could be responsible for the biological activity.
Havana Syndrome: A Mysterious Illness or a New Domain of
Warfare
Authors: Nath Soumitra
Published: March 2023

Havana syndrome cases increased in Cuba at the end of 2016 and early 2017, and the consequences
ranged from minor to severe health concerns. In almost all affected individuals, symptoms like
difficulty-concentrating, visual issues, brain-fog, memory problems, tinnitus, and sleep-related complaints
were reported. Some initial studies pointed the causative possibility towards energy weapons, ultrasound,
microwaves, microbes and chemicals. However, to date, no study has provided a comprehensive explanation
of this sudden mysterious syndrome, and the root cause remains unexplained.
Improving the performance of a lamb wave sensing array via relaxor ferroelectric single crystal transduction
Authors: Schipper M.J.
Published: March 2023

Abstract. This paper reports on the potential use of relaxor ferroelectric single crystal (RFSC) transduction to improve the sensitivity of the thin film multi-element Lamb wave sensor called LAMDA (linear array for modal decomposition and analysis). The previously reported LAMDA sensor was created using a high-density multi-element polyvinylidene fluoride (PVDF) electro-polymer sensing array. The electromechanical coupling factor k=d⁄√(ε^T*s^E ), which is proportional to the piezoelectric coefficient d, is considered important for an ultrasonic receiver such as LAMDA. Comparing the PVDF piezoelectric coefficient d31 ≈ 14 pC/N with that of a recent RFSC [011] Pb(Mg1/3Nb2/3)O3-Pb(Zr,Ti)O3 (or Mn-PMN-PZT) having d32 ≈ -1100 pC/N, suggests the replacement of the PVDF array with a RFSC array could lead to a significant improvement in the sensitivity of the LAMDA sensor and consequently broaden the scope of its potential application to structural health monitoring. To this end, multiphysics modelling has been performed which indicates a five-fold increase in signal voltage output from a Mn-PMN-PZT based RFSC LAMDA compared with the original PVDF LAMDA. Model predictions for both RFSC LAMDA and PVDF LAMDA sensors will be reported, compared, and discussed.
An optimal sensor placement method for physical function assessment in living space
Authors: Yamane M.
Published: March 2023

Abstract. In recent years, the rapid aging of the population and the high incidence of fall accidents have been problems. Although conventional physical function assessments have been conducted by interviews with physicians or physical fitness tests, research and developments have been recently conducted on a system to be used in medical facilities by using motion capture systems or inertial measurement units to enable detailed and easy assessment. However, contact sensors constrain people’s movements during measurements. Furthermore, they may feel nervous during measurement at experimental sites or hospitals, and this causes different movements from usual. Thus, we have been suggesting a physical function assessment system that realizes the measurement of natural daily activities by introducing non-contact sensors into the living space. In conducting physical function evaluation in a living space, it is necessary to consider the set of conditions, such as sensor placement, from the viewpoint of privacy protection. In addition, because of the wide variety of living space designs, the determination of sensor positions is currently tailor-made to take into account measurable motion and privacy, so there is room for optimization. However, to begin with, there are few examples of measurement in actual living spaces, and standards of home-based sensing such as the actual measurable indices, and installation conditions are unclear. Therefore, the purpose of this study was to propose an optimization system for the placement of sensors in the living space for physical function evaluation. We proposed a system that simulates the amount of data on walking motions that can be obtained under each condition and the optimal placement of the RGB-D sensors based on that data. In this study, sensor placement was optimized based on the following three evaluation items: (1) residents do not feel discomfort, (2) walking motions can be measured, and (3) the sensor does not interfere with residents’ walking. The system was validated using floor plan information published in CASAS Smart Home Data sets, and we discussed its usefulness and issues.
Augmented architectural space system for the creation of casual connections with people
Authors: Suetomi Y.
Published: March 2023

Abstract. In recent years, the increasing social isolation has become a major problem in Japan because of the growing trend toward nuclear families. In addition, further social isolation is concerned caused by a decrease on face-to-face communication opportunities due to the outbreak of the COVID-19 infection. Therefore, it is necessary to create connections among people. On the other hand, opportunities for people to communicate online have increased rapidly. However, various information obtained the face-to-face is missing online, which degrades the quality of communication and causes physical and mental fatigue to users. To solve these problems, this study aims to minimize the gap that exists between online and the face-to-face, and to propose an Augmented Architectural Space that creates casual connections between people within their living space. By comparing the results of impression evaluation experiments using questionnaires for the face-to-face environment, the video conferencing system environment, and the proposed system environment, we demonstrate the usefulness of the proposed Augmented Architectural Space system for creating casual connections between people.
Action difficulty evaluation for high-rise buildings based on questionnaire and strong-motion records
Authors: Suzuki N.
Published: March 2023

Abstract. The present study describes the evaluation of feelings of difficulty faced by residents in performing actions during earthquakes (hereinafter, action difficulty) based on questionnaire surveys and strong-motion records for high-rise RC residential buildings having over 20 stories with seismic dampers or seismic isolation devices applied. In the recent structural design of buildings, both ensuring structural safety, such as the preservation of human lives during earthquakes, and evaluating the security of people in the buildings from the viewpoint of resilience, such as their continuous functionality and reduction of anxiety, are necessary. In the present study, focusing on the degree of the action difficulty, we propose a new evaluation formula based on the results of questionnaire surveys during earthquakes to evaluate the security of people in buildings. First, we analyze past questionnaire survey results in detail for the residents of high-rise residential buildings and show that the action difficulty is greatly reduced in seismically isolated buildings, as compared to earthquake-resistant buildings. On the other hand, for seismic response controlled buildings with steel dampers, no significant effect is determined in terms of action difficulty based on questionnaire surveys after massive earthquakes. Second, based on the relationship between the strong-motion records and the results of questionnaire surveys for the residents of high-rise buildings for the 2011 off the Pacific coast of Tohoku earthquake, we propose a new evaluation index to evaluate the security of people in the buildings and develop an evaluation formula for action difficulty. Third, we construct three-dimensional frame models with seismic dampers or seismic isolation devices in an existing high-rise RC residential building and evaluate the action difficulty for residents on each floor based on the proposed formula. Finally, we evaluate action difficulty during a medium-scale earthquake. The results indicate that the application of oil dampers and seismic isolation devices contributes to improving the security of people in buildings.
Development of deflection measurement method using smart cables with distributed fiber optic sensors
Authors: Nakashima T.
Published: March 2023

Abstract. The monitoring behavior of civil engineering structures under and after construction secures the quality and safety of structures. There is a possibility that spot measurements, which were frequently adopted in the past, fail to notice local deformation generated in non-measured points and such local deformation is sometimes generated in the ground and the concrete. Therefore, we paid attention to displacement measurement technology using fiber optic sensors capable of performing the distributed measurement. We considered measuring long civil engineering structures with a displacement accuracy of ±1 mm and conducted demonstration experiments to investigate this feasibility. In the experiment, we utilized 3DSensors (45 m and 170 m) that have the sufficient characteristic for application to civil engineering structures, such as high workability for the ground and structures and the actual achievements of field experiments, and the TW-COTDR system capable of performing measurements with high accuracy and at long distance. As a result, we demonstrated to measure the deflection of 2.5 mm with high accuracy.