bluuebunny/crossref_metadata_2025 huggingface dataset:
Upaya Meningkatkan Hasil Belajar IPA pada Siswa Kelas VII MTs Negeri 5 Gunungkidul Melalui Pendekatan SETS
Authors: Rahmawati Evy
Published: February 2023

Tujuan – Penelitian ini bertujuan untuk meningkatkan hasil belajar siswa kelas VII MTsN 5 Gunungkidul tahun pelajaran 2022/2023 dengan mengunakan pendekatan SETS.

Metode – Jenis Penelitian ini adalah penelitian tindakan kelas (PTK) yang menggunakan model penelitian Kemis dan Mc Taggart. Model Mc Taggart ini terdiri dari empat komponen yang berurutan yaitu perencanaan, tindakan, pengamatan dan refleksi, yang dalam pelaksanaan dan pengamatannya dilakukan secara bersamaan. Artinya pengamatan dilakukan pada saat proses pembelajaran. Subjek dalam penelitian ini adalah siswa-siswi kelas VII B MTsN 5 Gunungkidul tahun ajaran 2022/2023 yang berjumlah 25 siswa. Subjek penelitian ini sangat heterogen dilihat dari kemampuannya, yakni ada sebagian siswa yang memiliki kemampuan yang tinggi, sedang dan rendah. Teknik pengumpulan data dalam penelitian ini menggunakan lembar observasi, dokumentasi, angket, dan tes evaluasi.

Hasil – Berdasarkan hasil penelitian pada penelitian tindakan ini diperoleh diperoleh siklus I observasi sikap nilai rata-rata 77,00 dengan kriteria cukup dan ketuntasan 64,00%, sedangkan untuk keterampilan nilai rata- rata 71,40 dengan kriteria cukup dan ketuntasan 72,00%, sedangkan untuk pengetahuan nilai rata-rata 69,60 dengan kriteria kurang dan ketuntasan 53,33%. Siklus II, hasil observasi sikap nilai rata-rata 78,50 dengan kriteria cukup dan ketuntasan 76,00%, sedangkan untuk observasi keterampilan nilai rata-rata 74,00 dengan kriteria cukup dan ketuntasan 92,00%, sedangkan untuk pengetahuan nilai rata-rata 82,93 dengan kriteria cukup dan ketuntasan 88,00%.
Korupsi Massal dalam Perspektif Nomokrasi Islam (Studi Kasus Korupsi DPRD Malang)
Authors: Baskoro Aji
Published: February 2023

Korupsi merupakan permasalahan pelik di Indonesia. Tindakan korupsi yang mereka lakukan itu bukan hanya terjadi di pusat saja tapi juga di daerah. Salah satu kasus korupsi yang menjadi sorotan adalah korupsi massal DPRD Kota Malang. Ditinjau dari kaca mata nomokrasi Islam, korupsi massal tersebut telah menabrak prinsip-prinsip yang ada, seperti: prinsip kedaulatan (otoritas tertinggi), prinsip pengelolaan negara, prinsip relasi negara dan masyarakat dan prinsip tujuan sebuah negara. Perbuatan mereka dapat dikategorikan sebagai sariqah al-kubra (pencurian besar) yang hukumannya adalah hukuman mati. Selain itu, tindakan korupsi yang mereka lakukan tersebut juga telah melanggar norma-norma yang ada, baik secara ideologis, yuridis maupun sosiologis.
Fanatisme Politik Islam: Ideologisasi Partai Ka’bah di Jepara Masa Orde Baru dan Pasca Reformasi
Authors: Qosim M. Rizal
Published: February 2023

Dinamika politik dan parpol Islam di Jepara menunjukkan sebuah transformasi politik yang cukup radikal. Fanatisme politik masyarakat Jepara belakangan semakin luntur. Mereka bisa goyah dengan banyak pilihan politik yang ada.  Politik Jepara yang dulunya didominasi warna ‘hijau’ sekarang mulai dikuasai oleh warna ‘merah’. Perubahan ini tentunya menarik untuk diteliti. Hal yang hendak diungkap dari penelitian ini adalah apa faktor yang menyebabka fanatisme politik di Jepara dan apa faktor yang melahirkan transformasi politik Jepara dari ‘hijau’ ke ‘merah’.  Penelitian ini hendak menjawab dua rumusan masalah; apa yang menyebabkan masyarakat muslim Jepara menjadi ideologis dan fanatis terhadap PPP; dan mengapa terjadi pergeseran dari fanatisme PPP menjadi pragmatis dalam berpolitik di Jepara?
Larangan Kepemilikan Tanah Bagi WNI Keturunan Tionghoa di Yogyakarta Perspektif Hukum Positif
Authors: Maulana Afan Husni
Published: February 2023

Tulisan ini dilatarbelakangi Instruksi Gubernur DIY No: K.898/I/A/75 yang berisi bahwa warga non pribumi tidak diperbolehkan mempunyai memiliki hak kepemilikan tanah di Yogyakarta khususnya warga keturunan Tionghoa. Hal ini tentunya bertolak belakang dengan hak asasi manusia. Karena setiap warga negara berhak untuk memiliki hak milik tanah tanpa memandang agama, ras, kesukubangsaan maupun perbedaan yang lain seperti apa yang ada di dalam Pasal 16 ayat (1) UUPA. Menilik pokok masalah tersebut, maka pertanyaan mengapa Warga Negara Indonesia keturunan Tionghoa tidak diperkenankan memiliki hak milik tanah di Yogyakarta? Bagaimana larangan kepemilikan tanah WNI keturunan Tionghoa di Yogyakarta berdasarkan hukum positif? Penelitian ini termasuk studi pustaka yang bersifat deskriptif dengan pendekatan yuridis normatif. Hasil penelitian menunjukkan bahwa Instruksi Gubernur DIY No: K.898/I/A/75 memiliki sifat lex specialis derogat legi generali karena peraturan yang ditetapkan oleh Kepala Daerah Yogyakarta bertentangan dengan perundang-undangan yang ada di atasnya. Meskipun demikian, mereka tidak dapat mengajukan judicial review karena Yogyakarta sendiri diberi keistimewaan mengenai pertanahan seperti dalam Undang-undang Republik Indonesia nomor 13 tahun 2012 dalam Pasal 7. Itikad baik dari Gubernur DIY ialah untuk menghindari penguasaan tanah oleh warga keturunan Tionghoa seperti yang terjadi pada masa penjajahan. Ketika masyarakat tinggal di sebuah daerah istimewa harus siap dengan konsekuensinya seperti mengenai penetapan gubernur dan wakil gubernur yang semestinya ditetapkan secara demokratis, namun hal tersebut tidak berlaku di daerah istimewa.
Politik Hukum Desain Otonomi Khusus Ibu Kota Nusantara
Authors: Wibowo Torik Abdul Aziz
Published: February 2023

Pemindahan Ibu Kota Republik Indonesia dari Jakarta ke pulai Kalimantan menjadi semakin mendekati kenyataan dengan diundangkannya Undang-Undang Nomor 3 Tahun 2022 tentang Ibu Kota Negara. Salah satu materi muatan dalan UU ini adalah mengenai desain dari otonomi khusus yang diterapkan pada Ibu Kota Nusantara (IKN). Namun demikian, desain otonomi khusus IKN ini memiliki setidaknya dua persoalan konseptual, yakni: tidak jelasnya kedudukan pemerintahan daerah IKN dalam struktur pemerintahan Indonesia dan adanya kewenangan kepala otorita untuk memungut pajak dan retribusi sedangkan dalam desain otonomi khususnya IKN tidak dilembagakan dengan adanya DPRD. Tulisan ini kemudian mencoba melihat bagaimana politik hukum dari desain otonomi khusus IKN ini. Dan bagaimana desain perbaikan yang relevan terhadap desain Ikn tersebut. Hasil yang diperoleh yakni IKN memang sengaja didesain berada dalam kendali penuh pemerintah pusat. Dengan demikian perbaikan yang relevan adalah memang menempatkan IKN sebagai bagian dari pemerintah pusat.
Politik Hukum Pembentukan Undang-Undang Nomor 13 Tahun 2022 tentang Perubahan Kedua Atas Undang-Undang Nomor 12 Tahun 2011 Tentang Pembentukan Peraturan Perundang-Undangan
Authors: Ummah Vina Rohmatul
Published: February 2023

Pembentukan Undang-Undang Nomor 13 Tahun 2022 tentang Perubahan Kedua atas Undang-Undang Nomor 12 Tahun 2011 tentang Pembentukan Peraturan Perundang-Undangan merupakan tindak lanjut Pemerintah atas Putusan Mahkamah Konstitusi No. 91/PUU-XVIIII/2020 tentang Pengujian Formil Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja. Dengan adanya Putusan MK No. 91/PUU-XVIIII/2020 ini Undang-Undang Cipta Kerja dinyatakan Inkonstitusional Bersyarat atau cacat formil sebagaimana dalil permohonan gugatan uji formil Undang-Undang Cipta Kerja tertanggal 15 Oktober 2020 yang diterima di Kepaniteraan Mahkamah Konstitusi. Tujuan dari penelitian ini adalah untuk mengkaji sejauh mana arah kebijakan atau politik hukum pembentukan Undang-Undang Nomor 13 Tahun 2022. Jenis penelitian yang digunakan yaitu penelitian hukum normatif dengan menggunakan pendekatan perundang-undangan dan yuridis normatif dengan metode library research. Sumber data yang digunakan adalah data sekunder yang terdiri dari bahan hukum primer dan sekunder. Hasil dari penelitian ini menunjukan bahwa arah politik hukum pembentukan pembentukan UU No. 13 Tahun dengan jelas hanya dimaksudkan untuk menambah metode omnibus dalam UU Pembentukan Peraturan Perundang-Undangan atau semata-mata hanya untuk memberikan payung hukum terhadap pembentukan Undang-Undang Nomor 11 Tahun 2020 tentang Cipta Kerja. Meskipun mendapat penolakan dari berbagai kalangan, adanya demonstrasi, diskusi interaktif, hingga kritik dalam bentuk kertas kebijakan, Pembentuk Undang-Undang tetap tidak melakukan perubahan terhadap substansi maupun prosedur pembentukan UU Cipta Kerja. Hal ini semakin memperjelas political will pembentuk undang-undang hanya menjadikan revisi kedua UU No. 12 Tahun 2011 sebagai karpet merah melegitimasi UU Cipta Kerja.
Prepared for the SARS-CoV-2 Coronavirus? In Search of the Determinants of the Reaction to the First Wave of the COVID-19 Pandemic – the Case of Warsaw and Stockholm
Authors: Glinka Kamil
Published: February 2023

The article deals with the activity of municipal self-government administration during the COVID-19 pandemic. The aim of the article is to answer the question about the factors determining the reaction to the so-called first wave of the COVID-19 pandemic which was experienced by the municipal self-government administration of the two European cities: Warsaw (“hard” reaction) and Stockholm (“soft” reaction). Due to the hypothesis that the predictive and responsive potential of the municipal self-government administration of Warsaw and Stockholm differentiates their reaction to the so-called first wave of the COVID-19 pandemic, it was decided to use several research methods: comparative analysis, analysis of legal acts, analysis of statistical data and elements of system analysis. The conducted research proves that it is difficult to indicate the relationship between the predictive and responsive potential of the municipal self-government administration of Warsaw and Stockholm and its reaction to the so-called first wave of the COVID-19 pandemic. The sources of the difference in this reaction should therefore be sought in other factors.
Metabolomic analysis-identified 2-hydroxybutyric acid might be a key metabolite of severe preeclampsia
Authors: Wang Fang , Xu Lili , Qi Mingming , Lai Huimin , Zeng Fanhua , Liang Furong , Wen Qing , Ma Xihua , Zhang Chan , Xie Kaili
Published: February 2023

This study set out to determine the key metabolite changes underlying the pathophysiology of severe preeclampsia (PE) using metabolic analysis. We collected sera from 10 patients with severe PE and from 10 healthy pregnant women of the same trimester and analyzed them using liquid chromatography mass spectrometry. A total of 3,138 differential metabolites were screened, resulting in the identification of 124 differential metabolites. Kyoto encyclopedia of genes and genomes pathway analysis revealed that they were mainly enriched in the following metabolic pathways: central carbon metabolism in cancer; protein digestion and absorption; aminoacyl-transfer RNA biosynthesis; mineral absorption; alanine, aspartate, and glutamate metabolism; and prostate cancer. After analysis of 124 differential metabolites, 2-hydroxybutyric acid was found to be the most critical differential metabolite, and its use allowed the differentiation of women with severe PE from healthy pregnant women. In summary, our analysis revealed that 2-hydroxybutyric acid is a potential key metabolite for distinguishing severe PE from healthy controls and is also a marker for the early diagnosis of severe PE, thus allowing early intervention.
Effect of spaceflight on the phenotype and proteome of Escherichia coli
Authors: Liu Yu , Xu Chong , Zhao Guangxian , Wang Yanji , Zhu Yuanbing , Yin Yishu , Wang Jiaping , Li Yongzhi
Published: February 2023

Microbial safety has become a research hotspot with the development of manned space technology. Escherichia coli is a conditional pathogen that can cause infectious diseases. Therefore, it is necessary to study the influence of the space environment on E. coli. Phenotypic experiments including growth curves, morphology, and environmental resistance experiment were used to study the phenotypic changes of E. coli after exposure to the space environment for 12 days carried by the “SJ-10” satellite. Tandem mass tag was used to assess the proteome change of E. coli. We found that the survival rate of E. coli in the spaceflight group was decreased when cultivated in acidic and high-salt environments. Proteomic analysis identified 72 downregulated proteins involved in chemotaxis, intracellular pH elevation, glycolate catabolic process, and glutamate metabolic process in the spaceflight group. Meanwhile, only one protein mtr that was involved in the uptake of tryptophan in E. coli was upregulated in the spaceflight group. Our research showed that proteomics results can explain phenotypic results, which demonstrated the successful application of proteomics in mechanism research. Our data provide a comprehensive resource for understanding the effect of the space environment on E. coli.
Weyl asymptotics for perturbations of Morse potential and connections to the Riemann zeta function
Authors: Rahm Rob
Published: February 2023

LetN(T;V)N\left(T;\hspace{0.33em}V)denote the number of eigenvalues of the Schrödinger operator−y″+Vy-{y}^{^{\prime\prime} }+Vywith absolute value less thanTT. This article studies the Weyl asymptotics of perturbations of the Schrödinger operator−y″+14e2ty-{y}^{^{\prime\prime} }+\frac{1}{4}{e}^{2t}yon[x0,∞)\left[{x}_{0},\infty ). In particular, we show that perturbations by functionsε(t)\varepsilon \left(t)that satisfy∣ε(t)∣≲et| \varepsilon \left(t)| \hspace{0.33em}\lesssim \hspace{0.33em}{e}^{t}do not change the Weyl asymptotics very much. Special emphasis is placed on connections to the asymptotics of the zeros of the Riemann zeta function.
Influence of EPHX1 c.337 T>C and UGT2B7*2 genetic polymorphisms on the requirement of carbamazepine maintenance dose in persons with epilepsy (PWE) of Southern part of India: a cross-sectional genetic association study
Authors: Venkatraman Shravan , Ramasamy Kesavan , Nair Pradeep P. , Rajendran Priyadharsini
Published: February 2023

Objectives

Carbamazepine (CBZ) is a first-line antiseizure drug used for focal onset seizures. It exhibits inter-individual variability in plasma carbamazepine levels and there are both genetic and non-genetic factors having a role in the requirement of CBZ maintenance dose. The aim was to study the influence of EPHX1 c.337 T>C and UGT2B7*2 genetic polymorphisms on CBZ maintenance dose requirement in persons with epilepsy.

Methods

Persons with epilepsy (PWE) of both gender of age 15–65 years on carbamazepine monotherapy who had been taking same maintenance dose for one year were eligible. Five milliliter of venous blood was collected in 10% EDTA under aseptic precautions. After centrifugation, the cellular component was used for DNA extraction and genotyping. For three genotypes of EPHX1 c.337 T>C and UGT2B7*2, the differences in mean carbamazepine dose were analyzed using Analysis of Variance (ANOVA). An unpaired t-test was used to draw a comparison between the genotypes and CBZ maintenance dose requirement for dominant and recessive models of EPHX1 c.337 T>C and UGT2B7*2. A value of p<0.05 was considered to be statistically significant.

Results

For UGT2B7*2 (rs 7439366), CT required a higher dose (CT 626 mg/day and TT 523 mg/day) but not found to be significant (p-value 0.167). PWE carrying CT genotype of EPHX1 c.337 T>C had 62 mg higher dose when compared to homozygous mutant CC (590 mg/day for CT and 528 mg/day for CC) but p-value was not found to be significant (p-value 0.835).

Conclusions

The results of our study done in 115 PWE showed there was a lack of association between SNPs of EPHX1 c.337 T>C, UGT2B7*2 and CBZ maintenance dose requirement in Southern part of India and this finding has to be confirmed in a larger sample size.
Characterization of Kv1.2-mediated outward current in TRIP8b-deficient mice
Authors: Labbaf Afsaneh , Dellin Maurice , Komadowski Marlene , Chetkovich Dane M. , Decher Niels , Pape Hans-Chrisitian , Seebohm Guiscard , Budde Thomas , Zobeiri Mehrnoush
Published: February 2023

Tonic current through hyperpolarization-activated cyclic nucleotide-gated cation (HCN) channels is influencing neuronal firing properties and channel function is strongly influenced by the brain-specific auxiliary subunit tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b). Since Kv1.2 channels and TRIP8b were also suggested to interact, we assessed brain Kv1.2 mRNA and protein expression as well as the reduction of K+ outward currents by Kv1.2-blocking compounds (Psora-4; tityustoxin-Kα, TsTX-Kα) in different brain areas of TRIP8b-deficient (TRIP8b

−/−
) compared to wildtype (WT) mice. We found that transcription levels of Kv1.2 channels were not different between genotypes. Furthermore, Kv1.2 current amplitude was not affected upon co-expression with TRIP8b in oocytes. However, Kv1.2 immunofluorescence was stronger in dendritic areas of cortical and hippocampal neurons. Furthermore, the peak net outward current was increased and the inactivation of the Psora-4-sensitive current component was less pronounced in cortical neurons in TRIP8b

−/−
mice. In current clamp recordings, application of TsTX increased the excitability of thalamocortical (TC) neurons with increased number of elicited action potentials upon step depolarization. We conclude that TRIP8b may not preferentially influence the amplitude of current through Kv1.2 channels but seems to affect current inactivation and channel localization. In TRIP8b

−/−
a compensatory upregulation of other Kv channels was observed.
A multi-layered approach to developing academic written communication skills for nursing students
Authors: Garvey Loretta , Willetts Georgina , Herrmann Antje , Verezub Elena , Sinchenko Elena
Published: February 2023

Objectives

Academic literacy in nursing students has historically been poor this research therefore aimed to investigate the effectiveness of an embedded multidisciplinary approach to academic written communication skills for first year Bachelor of Nursing students in Australia.

Methods

This initiative consisted of (1) collaboratively embedding academic skills with nursing staff and Learning and Academic Skills Advisors using scaffolded tasks, curriculum/material development, workshops/tutorials on writing skills; and (2) individual support sessions. Data was obtained via questionnaire.

Results

Responses were received from 92 (74% local and 26% international) students. Key findings showed the collaborative approach to embedding skills with added follow up, was beneficial for students’ skills development, including improved academic writing, increased confidence, and recognition of the importance of academic writing.

Conclusions

It is important to equip student to develop academic literacy and an embedded academic literacy program has been determined to assist and may contribute to future professionalisation in nursing.
A derivative-Hilbert operator acting on Dirichlet spaces
Authors: Xu Yun , Ye Shanli , Zhou Zhihui
Published: February 2023

Let

μ

\mu

be a positive Borel measure on the interval

[

0
,
1

)

\left[0,1)

. The Hankel matrix

H

μ

=

(

μ

n
,
k

)

n
,
k
≥
0

{{\mathcal{ {\mathcal H} }}}_{\mu }={\left({\mu }_{n,k})}_{n,k\ge 0}

with entries

μ

n
,
k

=

μ

n
+
k

{\mu }_{n,k}={\mu }_{n+k}

, where

μ

n

=

∫

[

0
,
1

)

t

n

d
μ

(

t

)

{\mu }_{n}={\int }_{\left[0,1)}{t}^{n}{\rm{d}}\mu \left(t)

, induces formally the operator as follows:

DH

μ

(

f

)

(

z

)

=

∑

n
=
0

∞

∑

k
=
0

∞

μ

n
,
k

a

k

(

n
+
1

)

z

n

,

z
∈
D
,

{{\mathcal{D {\mathcal H} }}}_{\mu }(f)\left(z)=\mathop{\sum }\limits_{n=0}^{\infty }\left(\mathop{\sum }\limits_{k=0}^{\infty }{\mu }_{n,k}{a}_{k}\right)\left(n+1){z}^{n},\hspace{1em}z\in {\mathbb{D}},

where

f

(

z

)

=

∑

n
=
0

∞

a

n

z

n

f\left(z)={\sum }_{n=0}^{\infty }{a}_{n}{z}^{n}

is an analytic function in

D

{\mathbb{D}}

. In this article, we characterize those positive Borel measures on

[

0
,
1

)

\left[0,1)

for which

DH

μ

{{\mathcal{D {\mathcal H} }}}_{\mu }

is bounded (resp. compact) from Dirichlet spaces

D

α

(

0
<
α
≤
2

)

{{\mathcal{D}}}_{\alpha }\hspace{0.33em}\left(0\lt \alpha \le 2)

into

D

β

(

2
≤
β
<
4

)

{{\mathcal{D}}}_{\beta }\hspace{0.33em}\left(2\le \beta \lt 4)

.
Concentration evaluation and risk assessment of pesticide residues in selected vegetables sold in major markets of Port Harcourt South-South Nigeria
Authors: Omokpariola Daniel O. , Omokpariola Patrick L. , Okoye Patrice A. C. , Okechukwu Victor U. , Akolawole Joseph S. , Ifeagwu Ogochukwu
Published: February 2023

Concentration levels and health risk assessment of residues of organochlorine and organophosphate pesticides in four commonly vegetables (Cucumber, carrot, cabbage, and eggplant) collected from major markets of Port Harcourt city, South-south Nigeria were assessed. The collected samples were analysed using QuEChERS (quick, easy, cheap, effective, rugged, and safe) extraction method by gas chromatography coupled with Electron Capture Detector (ECD). Pesticide concentrations were compared with UK/EU maximum residual limits (MRLs). Health risk estimates were analysed using estimated daily intake (EDI), hazard quotient (HQ), and hazard ratio (HR) for children (16.7 kg) and adults (60 kg) weight groups. The results of this study showed that 80% of the vegetable samples contained detectable pesticide residues, of which 70% had residues that exceeded MRLs while 20% had residues below detectable levels. The highest concentrations of HCH residues are present in cabbage with a concentration of 0.25 ± 0.15 mg/kg for α-HCH while the least are present in eggplant with concentration of 0.038 ± 0.025 mg/kg in lindane. Pirimophos-methyl was detected in cucumber at 0.017 mg/kg while parathion and isofenfos was detected only in eggplants at concentration of 0.042 mg/kg and 0.022 mg/kg respectively. Concentrations of parathion, chlorpyrifos, and pirimophos-methyl residues were lower than MRLs in all the detected vegetable samples analysed. Non-carcinogenic health risk estimates for the children consumer groups showed that mevinfos, p, pʹ DDD, aldrin, and heptachlor epoxide detected in eggplant, carrot, and cabbage had HQ > 1. While for adults, only p, pʹ DDD and heptachlor epoxide revealed non-carcinogenic effect in cabbage. Risk was highest for child consumers. However, most of the pesticide residues were less than 1 for the HQs value which is indicative of insignificant health risk. Human risk estimations for the carcinogenic health effect for the studied vegetables showed that lindane and delta HCH could pose carcinogenic health risks to adult, while aldrin, dieldrin, heptachlor, α HCH, β HCH, delta HCH, and heptachlor epoxide could pose carcinogenic health risks to children. The HRI values in some of the detected residues indicate that the cancer benchmark concentrations exceeded the EDI for the respective organochlorine pesticide in the vegetable samples, thus raising serious concerns of possible carcinogenicity. Non carcinogenic and carcinogenic risk assessment of organochlorine pesticide residues in the studied vegetable indicates health threat. Hence, strict monitoring and control of pesticide residues in agricultural products is being suggested, to protect consumers, especially the children who are vulnerable to the adverse effects of pesticides.
Collateral Reforms and Access to Finance: Evidence from the West Bank and Gaza and Their Firms
Authors: Hrenko Zachary , Nugent Jeffrey B.
Published: February 2023

This paper examines the impact of an important financial reform, namely a collateral reform extending the assets, which could qualify as collateral for bank loans to the firms’ own equipment and moveable assets, so as to increase the access to such credit by small private firms. The reform studied was undertaken in the Palestinian territories of West Bank and Gaza (WBG) in the Middle East and North Africa (MENA) region where bank credit and financial markets have been especially heavily constrained. First, we apply two different synthetic control techniques to panel data covering both pre- and postreform years from both the WBG and a sample of comparable countries that did not undertake collateral reform. The results from both synthetic control methods show that such credit increased significantly after the reform in WBG but not in the nonreformed comparator countries. Then, we use comparable firm-level data obtained from a panel of all available firms in WBG from the Enterprise Survey of the World Bank, both 3 years before and 3 years after the reform to trace the impacts of the reform on various financial and other outcomes at the firm level. Despite the other difficulties that WBG was going through over the period, we find considerable evidence at the firm level that this collateral reform has been effective in stimulating credit, investment, and employment growth, especially among small firms, underscoring its potential for use by other low- and middle-income countries.
Egyetemi folyóirat-szerkesztőségek a nemzetközi láthatóság növelésének útján (Egy kerekasztal-beszélgetés tanulságai)
Authors:   University of Pécs Library and Knowledge Center, Department of Publication and Research Support, Lovász Dávid
Published: February 2023

The University of Pécs Library and Knowledge Center organized a conference for November 23rd, 2022. The purpose of the symposium was to introduce the new trends of Open Access scientific publishing and good Hungarian and international practices, as well as to present the opportunities aimed at efficiently supporting the publishing activity and measured academic accomplishments of university teachers and researchers. One of the professional blocks of the event was about the development possibilities of editorial offices and the international visibility of scientific output in the form of a round table discussion. At this discussion, the editors-in-chief and editors of altogether four journals from four university faculties (Hungarian Journal of African Studies, Public Administration and Infocommunications Law PhD Studies, Modern Geográfia, Tourism and Rural Development Studies) discussed possible development opportunities.
Phenylethanoid glycoside verbascoside ameliorates podocyte injury of diabetic kidney disease by regulating NR4A1-LKB1-AMPK signaling
Authors: Chen Xinyun , Shi Min , Yang Letian , Guo Fan , Liang Yan , Ma Liang , Fu Ping
Published: February 2023

Diabetic kidney disease (DKD) is one of the leading causes of end-stage renal disease. Verbascoside is a ubiquitous phenylethanoid glycoside with potent anti-inflammatory, antioxidant, and hypoglycemic properties. This study determined the renoprotective effect of verbascoside against DKD, as well as the underlying mechanism. After administration of verbascoside for 4 consecutive weeks, the fasting blood glucose level, albumin:creatinine ratio, and podocyte damage in diabetic mice were alleviated, especially at a dose of 150 mg/kg/d. Moreover, the inflammatory response, cell apoptosis, and autophagy were improved in a dose-dependent fashion in the kidneys of diabetic mice and high glucose-stimulated podocytes. Verbascoside reversed the elevated NR4A1 expression and suppressed LKB1 to inhibit AMPKα phosphorylation. Silencing NR4A1 inhibited LKB1 and phospho-AMPKα expression, and relieved the stress response in injured podocytes. Taken together, our results indicated that verbascoside alleviates DKD-associated podocyte injury by regulating NR4A1-LKB1-AMPK signaling.
From Panocha to Fudge
Authors: Charbonneau Patrick , Pilcher Jeffrey M.
Published: February 2023

Although the origins of the popular candy called fudge have been traced to American industrial processed foods of the 1880s, an early version known as panochita de leche was made in eighteenth-century Mexico using only rustic brown sugar and milk. The authors of this article combined the methodologies of physical chemistry and food history to examine the development of this dish using the science of sugar refining as well as manuscript and published cookbook recipes, memoirs, and travel accounts. Given the lack of Old World confectionery antecedents to the key technique of whisking the cooling sugar to induce crystallization, they attribute panochita to vernacular Mexican traditions of sugar refining and candy making.
Quality and Genuineness in the World of Sicilian Olive Oil
Authors: Hilton Amanda
Published: February 2023

This article draws on the concept of authenticity as it is often deployed in regards to food, and specifically in regards to foods with Geographical Indication certifications (GIs). Authenticity, as a concept, does boundary work by coding some objects or subjects as authentic, defining them against inauthentic others. Power dynamics inhere in any use of the processes of authentication, which render the authentic as noteworthy (Bendix 1997). Following calls to practice the “arts of noticing” (Tsing 2015) and to question our own ethnographic categories (De Martino 1975), this article takes the case of the olive oil sector in Sicily, Italy, and Sicilian Protected Geographical Indication (PGI) extra virgin olive oil, to think through authenticity and processes of authentication through the lens of two related concepts: quality (qualità) and genuineness (genuinità). I conceptualize qualità as a top-down articulation of authenticity: Sicilian olive and olive oil producers’ articulation of authenticity and excellence in response to a global hierarchy of value (Herzfeld 2004) in which they are situated and to which they respond. Genuinità, on the other hand, I argue is a bottom-up articulation of authenticity and goodness, one concerned less with international recognition and chemical purity and more with social relationships of trust and practices of commensality. I argue that qualità is a powerful measure of authenticity and a livelihood strategy for Sicilian oliviculturalists, but that genuinità is perhaps an even more powerful measure of authenticity in its capacity to create or reinscribe social bonds.
Tribological properties of electrospark depositing Ni-WS2 self-lubricating coating
Authors:   School of Equipment Engineering, Shenyang Ligong University, Shenyang 110159, China, Yuea M. , Zhao W. ,   Liaoshen lndusteries Croup Co. Ltd, Shenyang 110045, China, Wang S. ,   School of Equipment Engineering, Shenyang Ligong University, Shenyang 110159, China,   State Key Laboratory of Explosion Science and Technology, Beijing Institute of Technology, Beijing 100081, China, Li J. ,   b Liaoshen lndusteries Croup Co. Ltd, Shenyang 110045, China, Zhu C. ,   Chongqing Chang’an Industry (Group) Co. Ltd, Chongqing 401120, China, Jin H. ,   School of Equipment Engineering, Shenyang Ligong University, Shenyang 110159, China,   Chongqing Chang’an Industry (Group) Co. Ltd, Chongqing 401120, China, Guo C. ,   School of Equipment Engineering, Shenyang Ligong University, Shenyang 110159, China
Published: February 2023

A Ni-WS2 sintered electrode was used to prepare a coating on a CrNi3MoVA steel substrate by employing electrospark deposition technique. The nanomechanical and tribological properties of the coating were tested by using nanoindenter and tribometer, and the morphologies, composition and phase structure were obtained by utilizing scanning electron microscopy (SEM), energy dispersive X-ray spectrum (EDS) and X-ray diffraction(XRD). The results showed that the coating is even-distributed with nanostalline α-W strengthening phase dopants, and it has a strong metallurgical bonding with the substrate. The coating is composed of WS2, γ-Ni, α-W and Ni3S2 phases, and it exhibits outstanding tribological properties for its friction coefficient reduced about 79% and wear rate reduced about 96% in contrast to the CrNi3MoVA steel.
Magnetic and optical characteristics of Fe doped SrTiO3 perovskite compound: a first principle study
Authors:   Spin-Optoelectronics and Ferro-Thermoelectric (SOFT) Materials and Devices Laboratory, Department of Physics, University of Agriculture, Faisalabad 38040, Pakistan, Shafique H. , ldaghfag S. A. A ,   Department of Physics, College of Sciences, Princess Nourah bint Abdulrahman University (PNU), Riyadh 11671, Saudi Arabia, Kashif M. ,   Physics Department, Govt College University Faisalabad (GCUF), Allama Iqbal Road, Faisalabad 38000, Pakistan, Zahid M. ,   Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan, Yaseen M. ,   Spin-Optoelectronics and Ferro-Thermoelectric (SOFT) Materials and Devices Laboratory, Department of Physics, University of Agriculture, Faisalabad 38040, Pakistan, Iqbal J. ,   Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan, Misbah A. ,   Department of Chemistry, University of Agriculture, Faisalabad 38040, Pakistan, Neffati R. ,   Department of Physics - Faculty of Science - King Khalid University, P.O. Box 9004, Abha, Saudi Arabia,   Sciences of Tunis, University of Tunis El Manar, 1060 Tunis, Tunisia
Published: February 2023

In this study, we theoretically probed the electronic, magnetic and optical characteristics of Sr1-xFexTiO3 and SrTi1-xFexO3 perovskite materials with the implementation of DFT based Wein2K code. In both doping atom is partially removed by (Fe) dopant. The substitution of Fe at A-site in SrTiO3 consequences the half-metallic ferromagnetic (FHM) character, while the substitution of Fe at B-site in SrTiO3 resulted into metallic character of the studied material. Moreover, In Sr0.5Fe0.5TiO3 the local magnetic moment of Fe is slightly decreased, whereas in SrTi0.5Fe0.5O3 the Fe magnetic moment is highly decreased from its free space value 4 µB. This reduction is due to p-d hybridization. In case of Sr0.5Fe0.5TiO3, the exchange constants N0α for s-d and N0β for p-d interaction are computed. The optical response of studied materials is described by jn.hat Sr0.5Fe0.5TiO3 is a prominent candidate for spintronics applications.
Color tunable Gd2O3: Tb3+/Eu3+ nano-phosphors prepared via laser ablation in water
Authors:   State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510275, P. R. China, Deng H. W. , Chen D. H. ,   State Key Laboratory of Optoelectronic Materials and Technologies, School of Electronics and Information Technology, Sun Yat-sen University, Guangzhou 510275, P. R. China
Published: February 2023

Gd2O3 has been considered as a kind of good host material for photoluminescence. The method of laser ablation in liquid (LAL) is increasingly used for the preparation of Gd2O3 because it is green and usually simple. In this work, monoclinic Gd2O3:Tb3+/Eu3+ nano-phosphors were successfully synthesized by LAL method. The morphology, structure, and optical properties of the nano-phosphors were discussed. The color of fluorescence of Gd2O3:Tb3+/Eu3+ nano-phosphors were successfully turned by controlling the content of Tb3+ and Eu3+ . The results show that the synthesized Gd2O3:Tb3+/Eu3+ nano-phosphors are potential to be applied to display, lighting, biological imaging or other fields.
NICKEL THIN FILMS GROWN BY PULSED LASER DEPOSITION: INFLUENCE OF SUBSTRATE AND SUBSTRATE TEMPERATURE
Authors:   Department of Physics, University of Sargodha, Sargodha 40100, Pakistan, NAWAZ. RIZWAN M. , KALYAR M. A. ,   Department of Physics, University of Sargodha, Sargodha 40100, Pakistan, BELL C. ,   School of Physics, University of Bristol, Tyndall Avenue, BS8 1TL, UK, ANWAR-UL-HAQ M. ,   Department of Physics, University of Sargodha, Sargodha 40100, Pakistan, MAKHDOOM A. R. ,   Department of Natural Sciences and Humanities, Rachna College of Engineering and Technology, University of Engineering and Technology, Lahore 54890, Pakistan
Published: February 2023

Nickel thin films were grown on glass and copper substrate in ultrahigh vacuum at energy density 2×1010 watt/cm2 using Nd:YAG laser. XRD analysis showed the amorphous growth of thin film at low substrate temperature (Ts) while higher Ts supported crystalline growth. Magnetic moment, magnetic residual ratio and coercivity of thin films decreased with increase in Ts for both substrates. However, this decrease was sharp for films deposited on glass substrate as compared to that deposited on copper in Ts range 100oC-500oC. Electrical resistivity of thin film grown on glass substrate decreased while Hall carrier mobility increased with increase in Ts
THERMAL PROPERTIES OF PSS COATED COBALT ZINC FERRITE NANOPARTICLES SYNTHESIZED BY CO-PRECIPITATION METHOD
Authors:   Department of Physics, RIPHAH International University Islamabad, Pakistan, QURESHI T. N. , NASIR M. F. ,   Department of Physics, RIPHAH International University Islamabad, Pakistan
Published: February 2023

In this work Cobalt Zinc Ferrite nanoparticles Co1-xZnxFe2O4 for x = 0.25, 0.5 and 0.75 were synthesized via coprecipitation method. Annealing of all the samples was carried out at 700 ºC for 5 hours. To investigate the crystal structure XRD analysis was used which confirmed the ferrite structure of synthesized samples. Afterwards surface coating of all the samples was done by biocompatible polymer PSS. Surface functionalization of magnetic nanoparticles with PSS (Polystyrene Sulphonate) was confirmed by FTIR spectrum of samples from 2000 cm-1 to 4000 cm-1 . Thermal properties and temperature variation with oscillating magnetic field was investigated by RF induction method. That showed increasing temperatures with decreasing concentration of Zinc content.Also Increase in temperature was observed directly related to the frequency of applied magnetic field and concentration of Cobalt in the sample. SAR values for the sample were estimated using specific heat of samples and temperature slope and it was observed that SAR is directly related to cobalt content as well as inversely to the Zn content in the samples.
APC/C‐dependent degradation of Spd2 regulates centrosome asymmetry in Drosophila neural stem cells
Authors: Meghini Francesco , Martins Torcato , Zhang Qian , Loyer Nicolas , Trickey Michelle , Abula Yusanjiang , Yamano Hiroyuki , Januschke Jens , Kimata Yuu
Published: February 2023

A functional centrosome is vital for the development and physiology of animals. Among numerous regulatory mechanisms of the centrosome, ubiquitin‐mediated proteolysis is known to be critical for the precise regulation of centriole duplication. However, its significance beyond centrosome copy number control remains unclear. Using an in vitro screen for centrosomal substrates of the APC/C ubiquitin ligase in Drosophila, we identify several conserved pericentriolar material (PCM) components, including the inner PCM protein Spd2. We show that Spd2 levels are controlled by the interphase‐specific form of APC/C, APC/CFzr, in cultured cells and developing brains. Increased Spd2 levels compromise neural stem cell–specific asymmetric PCM recruitment and microtubule nucleation at interphase centrosomes, resulting in partial randomisation of the division axis and segregation patterns of the daughter centrosome in the following mitosis. We further provide evidence that APC/CFzr‐dependent Spd2 degradation restricts the amount and mobility of Spd2 at the daughter centrosome, thereby facilitating the accumulation of Polo‐dependent Spd2 phosphorylation for PCM recruitment. Our study underpins the critical role of cell cycle–dependent proteolytic regulation of the PCM in stem cells.
A combinatorial panel for flow cytometry‐based isolation of enteric nervous system cells from human intestine
Authors: Windster Jonathan D , Sacchetti Andrea , Schaaf Gerben J , Bindels Eric MJ , Hofstra Robert MW , Wijnen Rene MH , Sloots Cornelius EJ , Alves Maria M
Published: February 2023

Efficient isolation of neurons and glia from the human enteric nervous system (ENS) is challenging because of their rare and fragile nature. Here, we describe a staining panel to enrich ENS cells from the human intestine by fluorescence‐activated cell sorting (FACS). We find that CD56/CD90/CD24 co‐expression labels ENS cells with higher specificity and resolution than previous methods. Surprisingly, neuronal (CD24, TUBB3) and glial (SOX10) selective markers appear co‐expressed by all ENS cells. We demonstrate that this contradictory staining pattern is mainly driven by neuronal fragments, either free or attached to glial cells, which are the most abundant cell types. Live neurons can be enriched by the highest CD24 and CD90 levels. By applying our protocol to isolate ENS cells for single‐cell RNA sequencing, we show that these cells can be obtained with high quality, enabling interrogation of the human ENS transcriptome. Taken together, we present a selective FACS protocol that allows enrichment and discrimination of human ENS cells, opening up new avenues to study this complex system in health and disease.
Deregulations of miR‐1 and its target Multiplexin promote dilated cardiomyopathy associated with myotonic dystrophy type 1
Authors: Souidi Anissa , Nakamori Masayuki , Zmojdzian Monika , Jagla Teresa , Renaud Yoan , Jagla Krzysztof
Published: February 2023

Myotonic dystrophy type 1 (DM1) is the most common muscular dystrophy in adults. It is caused by the excessive expansion of noncoding CTG repeats, which when transcribed affects the functions of RNA‐binding factors with adverse effects on alternative splicing, processing, and stability of a large set of muscular and cardiac transcripts. Among these effects, inefficient processing and down‐regulation of muscle‐ and heart‐specific miRNA, miR‐1, have been reported in DM1 patients, but the impact of reduced miR‐1 on DM1 pathogenesis has been unknown. Here, we use Drosophila DM1 models to explore the role of miR‐1 in cardiac dysfunction in DM1. We show that miR‐1 down‐regulation in the heart leads to dilated cardiomyopathy (DCM), a DM1‐associated phenotype. We combined in silico screening for miR‐1 targets with transcriptional profiling of DM1 cardiac cells to identify miR‐1 target genes with potential roles in DCM. We identify Multiplexin (Mp) as a new cardiac miR‐1 target involved in DM1. Mp encodes a collagen protein involved in cardiac tube formation in Drosophila. Mp and its human ortholog Col15A1 are both highly enriched in cardiac cells of DCM‐developing DM1 flies and in heart samples from DM1 patients with DCM, respectively. When overexpressed in the heart, Mp induces DCM, whereas its attenuation rescues the DCM phenotype of aged DM1 flies. Reduced levels of miR‐1 and consecutive up‐regulation of its target Mp/Col15A1 might be critical in DM1‐associated DCM.
The effectiveness of vocational training programs for schoolchildren: Educational, career and migration strategies
Authors:   South Ural State University (National Research University), Telyubaeva Anara Zholaushobaevna
Published: February 2023

Introduction. The article focuses on the programs for integration of education, science and production, which have a positive impact on the economy of the regions and social processes. One of the programs for integrating science, education and production is the vocational training program for schoolchildren, the effectiveness of which is insufficiently studied. The purpose of the article is to examine the effectiveness of vocational training programs for schoolchildren from the perspective of implementing educational, career and migration strategies. Materials and Methods. The review of the implemented vocational training programs for schoolchildren of the Chelyabinsk region was carried out by analyzing legal, economic and statistical data, reports and accounts. The study of the effectiveness of vocational training programs for schoolchildren is based on the analysis of career, migration and educational strategies of students identified through the use of a qualitative research method (a survey). Data processing was conducted using analysis, generalization, comparison, graphical interpretation, and verification. Results. The study shows that scholarly literature lacks unified approaches to assessing the effectiveness of vocational training programs for schoolchildren. Based on the data describing the implementation of vocational training programs for schoolchildren of the Chelyabinsk region, the authors have analyzed the following components within their structure: directions, technologies, mechanisms of organization, learning tools, forms of interaction with organizations of vocational education and production. The survey has revealed that vocational training programs in schools in the Chelyabinsk region contribute to solving the problems of supplementary education, student employment, and professional trials, but do not affect the migration and career attitudes of students. The results of the survey suggest a weak correlation between vocational training programs and career, educational and migration attitudes of students. Conclusions. The article concludes that vocational training programs not only aim to train employees for the region, but also fulfill the function of professional self-determination and social education.
La poesía de Delmira Agustini: entre el Modernismo y la Vanguardia
Authors: García de Saracho Mercedes
Published: February 2023

En este trabajo se analiza el paso del modernismo a la vanguardia a partir de la poesía de Delmira Agustini como movimientos en continuidad y no como compartimentos estancos. Un recorrido por la crítica más significati-va en lo que respecta a la autora y a su inclusión en un movimiento u otro, así como el estudio de los rasgos modernistas y vanguardistas más característicos de su obra, permiten leer a Agustini como un antecedente de la vanguardia es-tética y comprender las aportaciones que hizo al campo literario de su tiempo.
The use of blockchain in the organisation of annual general meetings: legal and technological challenges
Authors: Tamašauskas Nedas , Tamulionytė Luka
Published: February 2023

This article analyses the practical application of blockchain technology in the organisation of annual general meetings. The paper presents examples of the spreading application of the technology in foreign companies. In addition, it discusses the legal regulation of the organisation of annual general meetings in Lithuania, which is relevant for the practical application of the technology: authentication of shareholders and voting. Furthermore, the perspectives of blockchain technology in the Lithuanian market and its companies are reviewed.
Future math teachers ‘knowledge about fair games
Authors: De Armas Tulio Amaya
Published: February 2023

This work reports the results of a study whose objective was to analyze the didactic-mathematical knowledge of future mathematics teachers when solving an unequal game. The sample was made up of 24 future professors from a Chilean university. Task-based interviews were used to collect the information. The results show that future teachers have adequate intuitive ideas about expected value, prioritize the classical approach to solve situations and determine if the game is fair or not, taking into account both the probability of winning or losing the game, and the value that is gained or lost, using few solution strategies, which makes it easier for them to combine their statistical thinking with its teachableness. It concludes on the need to improve the teachability of probability, in both disciplinary and didactic aspects, suggesting support for teachers, both in training and in practice.
Is Your Practice Experiencing Down-coding?
Authors:   American Academy of Pediatrics
Published: February 2023

How do you know if you have been affected by down-coding? What is your risk? This article will review some of the risk factors, signs and symptoms, and potential treatment of down-coding as outlined by the American Academy of Pediatrics (AAP) “Prepayment Downcoding Checklist” (https://downloads.aap.org/AAP/PDF/Downcoding%20Checklist.pdf).

Down-coding policies affect payment for evaluation and management (E/M) services. The risk of down-coding is higher for some physicians and other qualified health care professionals (QHPs). Underpayment caused by down-coding may pass through the billing office unnoticed. Treatment of down-coding depends on the level of coding accuracy identified in chart reviews.
Selecting the Right Codes for In-office Laboratory Testing
Authors:   American Academy of Pediatrics
Published: February 2023

This article reviews differences in code categories and reporting instructions for point-of-care laboratory testing, including the following:

Clinical Laboratory Improvement Amendments (CLIA) status Codes by test type Coding for related services