bluuebunny/crossref_metadata_2025 huggingface dataset:
Internet use in old age predicts smaller cognitive decline only in men
Authors: Ihle Andreas , Bavelier Daphne , Maurer Jürgen , Oris Michel , Kliegel Matthias
Published: June 2020

Internet use provides cognitive stimulation and thereby may contribute to the accumulation of cognitive reserve that is proposed to be instrumental for maintaining cognitive health in ageing. As the first study so far, we examined possible gender differences in the relationship between Internet use and subsequent cognitive decline over six years assessed through changes in Trail Making Test (TMT) accomplishment time in 897 older adults. Latent change score modelling (taking into account baseline cognitive level, chronic diseases, age, and central contributions to cognitive reserve through education, profession, and leisure engagement) revealed a significant interaction of frequency of Internet use and gender. More frequent Internet use in the first wave of data collection significantly predicted a smaller subsequent augmentation in TMT accomplishment time (i.e., a smaller subsequent cognitive decline) only in men, but not in women. In conclusion, frequent Internet use may contribute to the accumulation of cognitive reserve. The gender difference noted highlights an advantage for males. While this finding could be interpreted as gender-specific, it may be that the Internet activities males engage in differ from those of females, calling for a fine-grained investigation of Internet-based activities in future studies.
Use of biogenic silver nanoparticles in enhancing shelf life of Morus alba L. at post harvest stage
Authors: Das Dipayan , Mandal Palash
Published: June 2020

Morus alba is one of the most important cultivated crop in Indian sub-continent contributing towards production of silk fibre that carries economic importance worldwide. Post harvest preservation of M. alba leaves is a challenging factor as decrease in concentration of essential metabolites that needed for silk gland development takes place. Decrease in chlorophyll, protein, sugar concentration and increase in accumulation of free radicals and ROS takes place at post harvest stage of preservation, putting negative impact on larval development indicated by high mortality rate. Silver nitrate and nanosilver solution acts as an effective preservative, enhances the activity of enzymatic and non-enzymatic antioxidants thereby reducing the harmful effect of accumulated free radicals and ROS. The effectiveness of nanosilver solution was found to be on the upper site without any significant difference than silver nitrate, as higher retention of primary metabolites like pigments, proteins, and sugar takes place. The impact of feeding nanosilver preserved leaves on silkworm was found on the positive trend as larval growth rate, cocoon weight, shell weight, effective rate of rearing was observed almost same to the larvae fed with fresh leaves.
Carbon-based dots for the electrochemical production of hydrogen peroxide
Authors: Dong Yongqiang , Su Juanxia , Zhou Shuqing , Wang Min , Huang Shuping , Lu Chun-Hua , Yang Hongbin , Fu Fengfu
Published: June 2020

Graphene/carbon-based dot nanohybrids were prepared by the ultrasonic exfoliation of natural graphite in the presence of single-layer carbon based dots, and used for the electrochemical production of hydrogen peroxide.
LC-MS analysis of p-aminosalicylic acid under electrospray ionization conditions manifests a profound solvent effect
Authors: Chandran Jisha , Zheng Zhaoyu , Thomas Vibin Ipe , Rajalakshmi C. , Attygalle Athula B.
Published: June 2020

Under identical mass spectrometric conditions, chromatographic peak intensities of p-aminosalicylic acid recorded by LC-MS, using methanol as the mobile phase are drastically different from those acquired using is it acetonitrile as the eluent.
Electrochemiluminescent sensors as a screening strategy for psychoactive substances within biological matrices
Authors: Brown Kelly , Jacquet Charlotte , Biscay Julien , Allan Pamela , Dennany Lynn
Published: June 2020

Electrochemiluminescent sensors for point-of-care devices; a screening strategy for the direct detection of hallucinogens within a variety of biological matrices.
An ethylene cross-bridged pentaazamacrocycle and its Cu2+complex: constrained ligand topology and excellent kinetic stability
Authors: Shircliff Anthony D. , Burke Benjamin P. , Davilla Dustin J. , Burgess Gwendolyn E. , Okorocha Faith A. , Shrestha Alina , Allbritton Elisabeth M. A. , Nguyen Phillip T. , Lamar Rachael L. , Jones Donald G. , Gorbet Michael-Joseph , Allen Michael B. , Eze John I. , Fernandez Andrea T. , Ramirez Daniel , Archibald Stephen J. , Prior Timothy J. , Krause Jeanette A. , Oliver Allen G. , Hubin Timothy J.
Published: June 2020

Extending the benefits of ethylene cross-bridging to pentaazamacrocycles has been achieved and a transition metal complex prepared and structurally characterized.
Gestated uniform yolk–shell Sn@N-doped hollow mesoporous carbon spheres with buffer space for boosting lithium storage performance
Authors: Wu Xiaoyu , Qian Chen , Wu Huayu , Xu Lin , Bu Lingli , Piao Yuanzhe , Diao Guowang , Chen Ming
Published: June 2020

Based on the confined growth strategy and hydrogen thermal reduction, we constructed and synthesized uniform yolk–shell structured Sn@NHMCSs, which exhibit high specific capacity and good cycling stability as an anode material in lithium ion batteries.
All-thiolate-stabilized Ag42 nanocluster with a tetrahedral kernel and its transformation to an Ag61 nanocluster with a bi-tetrahedral kernel
Authors: Chen Tao , Yang Sha , Song Yongbo , Chai Jinsong , Li Qinzhen , Ma Xiangyu , Li Guang , Yu Haizhu , Zhu Manzhou
Published: June 2020

Two new silver nanoclusters, formulated as Ag42(SBut)24 and Ag61(SC6H11)40Cl were prepared by a NaSbF6-mediated two-phase ligand exchange method. A size conversion from Ag42 to Ag61 were achieved via cyclohexanethiol etching.
Bifunctional pyridoxal derivatives as efficient bioorthogonal reagents for biomacromolecule modifications
Authors: Mao Xianxian , Li Wei , Zhu Shiyu , Zou Juan , Tian Hongyan , Duan Yuting , Wang Yuntao , Fei Jiayue , Wang Xiaojian
Published: June 2020

Bifunctional pyridoxal derivatives were developed and applied for a variety of bioorthogonal applications.
Liquid crystal elastomer actuator with serpentine locomotion
Authors: Wang Meng , Hu Xin-Bao , Zuo Bo , Huang Shuai , Chen Xu-Man , Yang Hong
Published: June 2020

In this manuscript, we describe a snake-mimic soft actuator with serpentine locomotion, which can move forward relying on a reversible shape morphing between S-curve and reverse S-curve structures.
2D magnetic MOFs with micron-lateral size by liquid exfoliation
Authors: León-Alcaide Luis , López-Cabrelles Javier , Mínguez Espallargas Guillermo , Coronado Eugenio
Published: June 2020

Herein, we obtained high-quality nanosheets for a whole family of Fe-based magnetic MOFs, MUV-1-X, through a liquid exfoliation procedure.
Quantum-chemistry-aided identification, synthesis and experimental validation of model systems for conformationally controlled reaction studies: separation of the conformers of 2,3-dibromobuta-1,3-diene in the gas phase
Authors: Kilaj Ardita , Gao Hong , Tahchieva Diana , Ramakrishnan Raghunathan , Bachmann Daniel , Gillingham Dennis , von Lilienfeld O. Anatole , Küpper Jochen , Willitsch Stefan
Published: June 2020

The successful separation of the gauche and s-trans conformers of 2,3-dibromobutadiene paves the way for studies of conformer-selected polar cycloaddition reactions in a cold and controlled environment.
Scalable spectrally selective mid-infrared meta-absorbers for advanced radiative thermal engineering
Authors: Liu Xianghui , Chang Qi , Yan Max , Wang Xin , Zhang Haiwen , Zhou Han , Fan Tongxiang
Published: June 2020

Selective broadband meta-absorbers in the mid-infrared range are achieved using residual fluctuation in diameters of resonators etched by monodisperse colloidal particles.
The role of the iodine-atom adduct in the synthesis and kinetics of methyl vinyl ketone oxide—a resonance-stabilized Criegee intermediate
Authors: Lin Yen-Hsiu , Li Yu-Lin , Chao Wen , Takahashi Kaito , Lin Jim Jr-Min
Published: June 2020

The adduct decomposition is the major pathway that forms CH3(C2H3)COO (MVKO) + I via the reaction of CH3(C2H3)CI + O2 for P > 50 Torr. The related kinetics of the adduct and MVKO + SO2 reactions have been studied over 4–700 Torr and 278–319 K.
Plasmonic nano-shells: atomistic discrete interaction versus classic electrodynamics models
Authors: Zakomirnyi Vadim I. , Rasskazov Ilia L. , Sørensen Lasse K. , Carney P. Scott , Rinkevicius Zilvinas , Ågren Hans
Published: June 2020

Using the extended discrete interaction model and Mie theory, we investigate the tunability of the optical polarizability and show the size-dependence of the plasma frequency of small metallic nano-shells in the 1–15 nm size region.
Unified and transferable description of dynamics of H2 dissociative adsorption on multiple copper surfaces via machine learning
Authors: Zhu Lingjun , Zhang Yaolong , Zhang Liang , Zhou Xueyao , Jiang Bin
Published: June 2020

Schematic of the developed neural network potential energy surface enabling a unified and transferable description of dynamics of H2 dissociative adsorption on multiple copper surfaces.
Coking-resistant dry reforming of methane over BN–nanoceria interface-confined Ni catalysts
Authors: Lu Meirong , Zhang Xiaoyu , Deng Jiang , Kuboon Sanchai , Faungnawakij Kajornsak , Xiao Shengxiong , Zhang Dengsong
Published: June 2020

Coking-resistant dry reforming of methane over BN–nanoceria interface-confined Ni catalysts was demonstrated.
A novel green approach based on ZnO nanoparticles and polysaccharides for photocatalytic performance
Authors: Araujo Francisca P. , Trigueiro Pollyana , Honório Luzia M. C. , Furtini Marcelo B. , Oliveira Dyego M. , Almeida Luciano C. , Garcia Ramón R. P. , Viana Bartolomeu C. , Silva-Filho Edson C. , Osajima Josy A.
Published: June 2020

Novel green photocatalysts based on ZnO in the presence of arabic gum (AGZ) or karaya gum (KGZ) were synthesized by a sol–gel method for photocatalytic performance.
Heterobimetallic μ2-carbido complexes of platinum and tungsten
Authors: Burt Liam K. , Hill Anthony F.
Published: June 2020

The tungsten–platinum μ-carbido complex [WPt(μ-C)Br(CO)2(PPh3)2(Tp*)] (Tp* = hydrotris(dimethylpyrazol-1-yl)borate) undergoes facile substitution of both bromide and phosphine ligands to afford a diverse library of μ-carbido complexes.
Oxidative addition of tetrathiocins to palladium(0) and platinum(0): a route to dithiolate coordination complexes
Authors: Watanabe Lara K. , Wrixon Justin D. , Ahmed Zeinab S. , Hayward John J. , Abbasi Parisa , Pilkington Melanie , Macdonald Charles L. B. , Rawson Jeremy M.
Published: June 2020

Functionalized benzenedithiolate complexes of Pt and Pd were prepared by oxidative addition of a library of 1,2,5,6-tetrathiocins to M2(dba)3. The oxidation potentials of crown-ether derivatives were increased upon binding Na+ ions.
A structurally aligned nickel oxide encapsulated polypyrrole nanocomposite for hydrogen peroxide sensing
Authors: Singh Pratibha , Shukla S. K.
Published: June 2020

Chemically responsive and structurally aligned nickel oxide encapsulated polypyrrole nano-composite has been prepared for H2O2sensing in liquid and vapor phase.
Anisotropic carrier diffusion in single MAPbI3 grains correlates to their twin domains
Authors: Hermes Ilka M. , Best Andreas , Winkelmann Leonard , Mars Julian , Vorpahl Sarah M. , Mezger Markus , Collins Liam , Butt Hans-Jürgen , Ginger David S. , Koynov Kaloian , Weber Stefan A. L.
Published: June 2020

The anisotropic charge carrier diffusion coupled to ferroelastic twin domains in methylammonium lead iodide opens possibilities for further optimization of perovskite solar cells and optoelectronic devices via strain engineering and heat treatments.
Matrix effects in atmospheric pressure nitrogen microwave induced plasma optical emission spectrometry
Authors: Pelipasov Oleg V. , Polyakova Evgeniya V.
Published: June 2020

The matrix effects in MIP OES arising in the presence of elements with Eion 5.13–9.39 eV (Na, Cu, Pb, Cd, Zn) depending on the concentration, nebulization flow rate, and plasma power were studied.
Both metal-chelating and free radical-scavenging synthetic pentapeptides as efficient inhibitors of reactive oxygen species generation
Authors: Csire Gizella , Canabady-Rochelle Laetitia , Averlant-Petit Marie-Christine , Selmeczi Katalin , Stefan Loic
Published: June 2020

Reactive oxygen species (ROS) are major sources of oxidative stress playing prominent roles in the development of several pathologies including cardiovascular and neurodegenerative diseases or cancers. The presence of transition biometal ions, specifically copper and iron, induces ROS formation by catalyzing the reduction of molecular oxygen to superoxide anion (O2˙−), hydrogen peroxide (H2O2) and hydroxyl (HO˙) radical. To limit ROS production and their detrimental effects, we report on the synthesis, physicochemical studies and antioxidant assays of an innovative series of synthetic pentapeptides exhibiting a dual direct/indirect mode of action, both as iron(iii)-chelators and as radical scavengers. These combined effects lead to a drastic reduction of in vitro reactive oxygen species production up to 95% for the more reactive hydroxyl radical.
Design, synthesis, and anti-proliferative evaluation of 1H-1,2,3-triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates in estrogen responsive and triple negative breast cancer cells
Authors: Sharma Bharvi , Gu Liang , Pillay Ruvesh Pascal , Cele Nosipho , Awolade Paul , Singh Parvesh , Kaur Mandeep , Kumar Vipan
Published: June 2020

A series of 1H-1,2,3 triazole grafted tetrahydro-β-carboline-chalcone/ferrocenylchalcone conjugates were synthesized and in vitro evaluated against estrogen responsive (MCF-7) and triple negative (MDA-MB-231) breast cancer cells.
Direct carbonization of black liquor powders into 3D honeycomb-like porous carbons with a tunable disordered degree for sodium-ion batteries
Authors: Huang Jianyu , Zhang Weicai , Yu Peifeng , Dong Hanwu , Zheng Mingtao , Xiao Yong , Hu Hang , Liu Yingliang , Liang Yeru
Published: June 2020

The 3D honeycomb-like porous carbon with a decreased disordered degree exhibits enhanced rate performance for Na-ion batteries.
Allyl sulfide-based visible light-induced dynamically reshaped liquid crystalline elastomer/SWCNT nanocomposites capable of multimode NIR photomechanical actuations
Authors: Wu Zhongying , Cheng Pin , Zhao Weiguang , Fang Jianglin , Xu Tianchi , Chen Dongzhong
Published: June 2020

The fully light-driven LCE/SWCNT composite films with exchangeable covalent crosslinks possess reconfigurability and recyclability, enabling shrinking, bending and curling motions.
A novel AIE chemosensor based on a coumarin functionalized pillar[5]arene for multi-analyte detection and application in logic gates
Authors: Dong Hong-Qiang , Ma Xiao-Qiang , Wei Tai-Bao , Yang Qing-Yu , Zhang Yun-Fei , Zhang Qin-Peng , Yao Hong , Zhang You-Ming , Lin Qi
Published: June 2020

A novel coumarin functionalized pillar[5]arene (PX) with AIE fluorescence could sequentially detect multiple analytes in aqueous medium with high sensitivity.
The PVP-assisted construction of a Co3V2O8@NiCo LDH hierarchical structure for high-performance lithium-ion batteries
Authors: Zhang Shuai , Zhang Li , Xu Guancheng , Zhang Xiuli , Zhao Aihua
Published: June 2020

In this paper, we reported 3D hierarchical Co3V2O8@NiCo LDH through the assistant of PVP. The composite exhibits outstanding lithium storage performance (1329.4 mA h g−1 at 1 A g−1, 893.1 mA h g−1 at 5 A g−1 after 950 cycles). Our work reported an effective method to prepare multi-component materials.
Improved photoremoval performance of boron carbon nitride–pyromellitic dianhydride composite toward tetracycline and Cr(vi) by itself to change the solution pH
Authors: Yan Congcong , Guo Yong , Wang Peifang , Rao Lei , Ji Xin , Guo Ying
Published: June 2020

A series of boron carbon nitride–pyromellitic dianhydride (BCNPA) composites were successfully synthesized for the first time, where BCNPA3 exhibited the best adsorption and photodegradation performances for tetracycline (TC) under visible-light irradiation.
Ultra-high energy density supercapacitors using a nickel phosphide/nickel/titanium carbide nanocomposite capacitor electrode
Authors: Xu Jing , Yang Nianjun , Yu Siyu , Schulte Anna , Schönherr Holger , Jiang Xin
Published: June 2020

The low energy density of traditional supercapacitors has strongly restricted their applications.
One-pot synthesis of β-O-4 lignin modelsviathe insertion of stable 2-diazo-1,3-dicarbonyls into O–H bonds
Authors: Dias Rafael Mafra P. , de Oliveira Gabriela P. , Burtoloso Antonio C. B.
Published: June 2020

A direct and easy approach for the preparation of popular lignin models is described by using the O–H insertion reaction from diazocompounds. This method avoids the use of haloketones and long synthetic routes commonly used to prepare these models.
Synthesis and practical applications of 2-(2-nitroalkyl)pyrroles
Authors: Palmieri Alessandro , Petrini Marino
Published: June 2020

Two main approaches can be designed for the synthesis of 2-(2-nitroalkyl)pyrroles using nitroalkenes or nitroalkanes in the reaction with pyrrole derivatives. The obtained nitroalkyl pyrroles can be converted into various bioactive compounds.
Recent advances in the oxime-participating synthesis of isoxazolines
Authors: Liao Jianhua , Ouyang Lu , Jin Qi , Zhang Jian , Luo Renshi
Published: June 2020

This review is devoted to highlighting the main achievements in the development of methodologies for the synthesis of isoxazolines.
Interfacial synthesis of a large-area coordination polymer membrane for rewritable nonvolatile memory devices
Authors: Zhang Zepu , Nie Yijie , Hua Weiwei , Xu Jingxuan , Ban Chaoyi , Xiu Fei , Liu Juqing
Published: June 2020

Stable nonvolatile memory devices with a high ON/OFF current ratio have been realized based on a large-area two-dimensional coordination polymer membrane.
Uniform Cu/chitosan beads as a green and reusable catalyst for facile synthesis of iminesviaoxidative coupling reaction
Authors: Chutimasakul Threeraphat , Na Nakhonpanom Pakamon , Tirdtrakool Warinda , Intanin Apichai , Bunchuay Thanthapatra , Chantiwas Rattikan , Tantirungrotechai Jonggol
Published: June 2020

Uniform, spherical Cu/chitosan beads prepared using a software-controlled flow system as a green and conveniently recyclable catalyst for the efficient synthesis of various imines in short reaction time.
Enabling discrimination capability in an achiral F6BT-based organic semiconductor transistor via circularly polarized light induction
Authors: Cheng Junjie , Ge Feng , Zhang Can , Kuai Yan , Hou Penghui , Xiang Yifeng , Zhang Douguo , Qiu Longzhen , Zhang Qijin , Zou Gang
Published: June 2020

High-performance chiroptical sensing in achiral poly(fluorene-alt-benzothiadiazole) based OFETs could be enabled by circularly polarized light induction.
Mottness collapse in monolayer 1T-TaSe2 with persisting charge density wave order
Authors: Zhang Kang , Si Chen , Lian Chao-Sheng , Zhou Jian , Sun Zhimei
Published: June 2020

Strain can induce a Mott insulator-to-metal transition in monolayer 1T-TaSe2 without breaking its long-range charge density wave order.
Development and validation of a nomogram for assessing survival in patients with hepatocellular carcinoma after hepatectomy
Authors: Huo Rong-Rui , Liu Xu , Cui Jing , Ma Liang , Huang Kun-Hua , He Cai-Yi , Yang Yang , You Xue-Mei , Yuan Wei-Ping , Xiang Bang-De , Zhong Jian-Hong , Li Le-Qun
Published: June 2020

Background and aim: Assessing the average survival rate of patients with hepatocellular carcinoma (HCC) after hepatectomy is important for making critical decisions in everyday clinical practice. The present study aims to develop and validate a nomogram for assessing the overall survival probability for such patients.

Methods: The putative prognostic indicators for constructing the nomogram were identified using multivariable Cox regression and model selection based on the Akaike information criterion. The nomogram was subjected to internal and external validation. The nomogram endpoints were death within 1, 3, and 5 years.

Results: A consecutive sample of 522 HCC patients who underwent potentially curative hepatectomy was retrospectively analyzed. Age, Barcelona clinic liver cancer (BCLC) stage, tumor size, alanine transaminase, alpha fetal protein, and serum prealbumin were included in the final model. The nomogram's discriminative ability was good in the training set (C-index was 0.74 for 1 year, 0.73 for 3 years, 0.70 for 5 years) and was validated using both an internal bootstrap method (C-index was 0.73 for 1 year, 0.72 for 3 years, 0.69 for 5 years) and an external validating set (C-index was 0.72 for 1 year, 0.72 for 3 years, 0.69 for 5 years). The calibration plots for the endpoints showed optimal agreement between the nomogram's assessment and actual observations.

Conclusions: The nomogram (an Excel-based tool) can be useful for assessing the probability of survival at 1, 3, and 5 years in patients with HCC after hepatectomy.
GPNMB contributes to a vicious circle for chronic obstructive pulmonary disease
Authors: Zhang Xi-Juan , Cui Zhong-Hua , Dong Yan , Liang Xiu-Wen , Zhao Yan-Xin , Baranova Ancha , Cao Hongbao , Wang Ling
Published: June 2020

Osteoporosis (OP) is significant and debilitating comorbidity of chronic obstructive pulmonary disease (COPD). We hypothesize that genetic variance identified with OP may also play roles in COPD. We have conducted a large-scale relation data analysis to explore the genes implicated with either OP or COPD, or both. Each gene linked to OP but not to COPD was further explored in a mega-analysis and partial mega-analysis of 15 independently collected COPD RNA expression datasets, followed by gene set enrichment analysis (GSEA) and literature-based pathway analysis to explore their functional linked to COPD. A multiple linear regression (MLR) model was built to study the possible influence of sample size, population region, and study date on the gene expression data in COPD. At the first step of the analysis, we have identified 918 genes associated with COPD, 581 with OP, and a significant overlap (P<2.30e-140; 210 overlapped genes). Partial mega-analysis showed that, one OP gene, GPNMB presented significantly increased expression in COPD patients (P-value = 0.0018; log fold change = 0.83). GPNMB was enriched in multiple COPD pathways and plays roles as a gene hub formulating multiple vicious COPD pathways included gene MMP9 and MYC. GPNMB could be a novel gene that plays roles in both COPD and OP. Partial mega-analysis is valuable in identify case-specific genes for COPD.
MiR-22-3p suppresses sepsis-induced acute kidney injury by targeting PTEN
Authors: Wang Xudong , Wang Yali , Kong Mingjian , Yang Jianping
Published: June 2020

Background: Septic acute kidney injury is considered as a severe and frequent complication that occurs during sepsis. The present study was performed to understand the role of miR-22-3p and its underlying mechanism in sepsis-induced acute kidney injury.

Methods: Rats were injected with adenovirus carrying miR-22-3p or miR-NC in the caudal vein before cecal ligation. Meanwhile, HK-2 cells were transfected with the above adenovirus following LPS stimulation. We measured the markers of renal injury (blood urea nitrogen (BUN), serum creatinine (SCR)). Histological changes in kidney tissues were examined by hematoxylin and eosin (H&E), Masson staining, periodic acid Schiff staining and TUNEL staining. The levels of IL-1β, IL-6, TNF-α and NO were determined by ELISA assay. Using TargetScan prediction and luciferase reporter assay, we predicted and validated the association between PTEN and miR-22-3p.

Results: Our data showed that miR-22-3p was significantly down-regulated in a rat model of sepsis-induced acute kidney injury, in vivo and LPS-induced sepsis model in HK-2 cells, in vitro. Overexpression of miR-22-3p remarkably suppressed the inflammatory response and apoptosis via down-regulating HMGB1, p-p65, TLR4 and pro-inflammatory factors (IL-1β, IL-6, TNF-α and NO), both in vivo and in vitro. Moreover, PTEN was identified as a target of miR-22-3p. Furthermore, PTEN knockdown augmented, while overexpression reversed the suppressive role of miR-22-3p in LPS-induced inflammatory response.

Conclusions: Our results showed that miR-22-3p induced protective role in sepsis-induced acute kidney injury may rely on the repression of PTEN.
LPS promotes the progression of sepsis by activation of lncRNA HULC/miR-204-5p/TRPM7 network in HUVECs
Authors: Chen Xinghai , Song Debiao
Published: June 2020

Sepsis is a systemic inflammatory response syndrome caused by infection. Lipopolysaccharide (LPS) has been reported to induce inflammatory responses, and long non-coding RNA highly up-regulated in liver cancer (HULC) expression was associated with the progression of sepsis. But the role and underlying mechanism of HULC in LPS-induced sepsis remain unclear. Cell viability and apoptosis were measured by methyl thiazolyl tetrazolium (MTT) and flow cytometry assays, respectively. The levels of apoptosis-related proteins, inflammatory cytokines and transient receptor potential melastatin7 (TRPM7) were detected by western blot. Reactive oxygen species (ROS), superoxide dismutase (SOD) and malondialdehyde (MDA) levels were detected by dichloro-dihydro-fluorescein diacetate (DCFH-DA) method using commercial kit. HULC, microRNA-204-5p (miR-204-5p) and TRPM7 expressions in serum of sepsis patients and human umbilical vein endothelial cells (HUVECs) were examined by quantitative real-time polymerase chain reaction (qRT-PCR). Dual-luciferase reporter and RNA immunoprecipitation (RIP) assays were used to confirm the interaction between HULC and miR-204-5p, miR-204-5p and TRPM7. LPS stimulation restrained cell viability and facilitated apoptosis, inflammatory injury and oxidative stress in HUVECs. HULC and TRPM7 were increased and accompanied with decreased miR-204-5p expression in serum of sepsis patients. A significant negative correlation between miR-204-5p and HULC or TRPM7 was observed, and there was a positive relationship between expressions of HULC and TRPM7. Importantly, LPS inhibited the cell viability and induced apoptosis, inflammatory injury and oxidative stress of HUVECs by up-regulating the expressions of HULC and TRPM7, and down-modulating miR-204-5p expression. Mechanically, HULC positively regulated TRPM7 expression by sponging miR-204-5p in HUVECs. LPS impaired cell viability, and promoted cell apoptosis, inflammatory response and oxidative stress in HUVECs by regulating HULC/miR-204-5p/TRPM7 axis.
Inhibition of RNA-binding protein HuR reduces glomerulosclerosis in experimental nephritis
Authors: Liu Simeng , Huang Zhimin , Tang Anna , Wu Xiaoqing , Aube Jeffrey , Xu Liang , Xing Changying , Huang Yufeng
Published: June 2020

Recent identification of an RNA-binding protein (HuR) that regulates mRNA turnover and translation of numerous transcripts via binding to an ARE in their 3′-UTR involved in inflammation and is abnormally elevated in varied kidney diseases offers a novel target for the treatment of renal inflammation and subsequent fibrosis. Thus, we hypothesized that treatment with a selective inhibition of HuR function with a small molecule, KH-3, would down-regulate HuR-targeted proinflammatory transcripts thereby improving glomerulosclerosis in experimental nephritis, where glomerular cellular HuR is elevated. Three experimental groups included normal and diseased rats treated with or without KH-3. Disease was induced by the monoclonal anti-Thy 1.1 antibody. KH-3 was given via daily intraperitoneal injection from day 1 after disease induction to day 5 at the dose of 50 mg/kg BW/day. At day 6, diseased animals treated with KH-3 showed significant reduction in glomerular HuR levels, proteinuria, podocyte injury determined by ameliorated podocyte loss and podocin expression, glomerular staining for periodic acid-Schiff positive extracellular matrix proteins, fibronectin and collagen IV and mRNA and protein levels of profibrotic markers, compared with untreated disease rats. KH-3 treatment also reduced disease-induced increases in renal TGFβ1 and PAI-1 transcripts. Additionally, a marked increase in renal NF-κB-p65, Nox4, and glomerular macrophage cell infiltration observed in disease control group was largely reversed by KH-3 treatment. These results strongly support our hypothesis that down-regulation of HuR function with KH-3 has therapeutic potential for reversing glomerulosclerosis by reducing abundance of pro-inflammatory transcripts and related inflammation.
Clinical Reasoning for Speech Sound Disorders: Diagnosis and Intervention in Speech-Language Pathologists' Daily Practice
Authors: Diepeveen Sanne , van Haaften Leenke , Terband Hayo , de Swart Bert , Maassen Ben
Published: June 2020

Purpose

This study aims to give an insight in clinical reasoning (diagnosis and intervention) of speech-language pathologists (SLPs) in the Netherlands for children with speech sound disorder (SSD).

Method

The study featured a mixed-method (qualitative and quantitative) design. Semistructured interviews containing nondirective, open-ended questions were conducted with 33 SLPs, which were analyzed using a constant comparative analysis. Other SLPs (137) filled out a questionnaire on the same topics. Multiple-choice questions were analyzed by descriptive frequencies, while open-ended questions were analyzed thematically.

Results

The results indicate that SLPs use a variety of assessments to diagnose SSD, complemented by observation and, often, case history. In total, 85 different diagnostic labels were reported. The choice of intervention is based on what is appealing to the child and what matches his or her age as well as on the specific diagnosis and severity. Interventions are used for multiple speech disorders, and according to SLPs, parents play a large role in diagnostics and intervention.

Conclusion

These results reveal the need for (a) a clear and consistent terminology of diagnoses in the field of pediatric SSD, (b) a fast and easy-to-administer comprehensive differential diagnostic instrument in combination with an instrument to assess participation in everyday life, and (c) a tool to conduct a case history online.
Examining Useful Spoken Language in a Minimally Verbal Child With Autism Spectrum Disorder: A Descriptive Clinical Single-Case Study
Authors: Biller Maysoon F. , Johnson Cynthia J.
Published: June 2020

Purpose

This was a companion study to a previous one (Biller & Johnson, 2019). The purpose was to develop a detailed descriptive profile of a minimally verbal child with a unique medical history and autism spectrum disorder (ASD). The present report describes his social-cognitive and speech sound production abilities in relation to his potentially burgeoning spoken language.

Method

This in-depth, descriptive, clinical single-case study focused on a 3-year-old boy who was diagnosed with a chromosomal abnormality and ASD. The size of his spoken vocabulary fell at the upper limit for classifying a child as minimally verbal. His demographic information was obtained, in addition to general information from his mother. Four social-cognitive and three speech sound production abilities were assessed, as well as his overall performance in both domains. The study included a parent interview and two child assessment sessions.

Results

The child exhibited low social-cognitive and speech sound production abilities for his age, with social-cognitive abilities higher than speech sound production abilities. Comparison with the previous study revealed substantial gaps in social cognition and speech sound production between this child and five other minimally verbal children with ASD. His higher abilities in these two domains co-occurred with his larger spoken vocabulary size.

Conclusions

Although the child's social-cognitive abilities were low for his age, with his speech sound production abilities even lower, both domains were perhaps high enough to support spoken vocabulary at the upper limit for minimally verbal children. Indeed, there appeared to be quantitative and qualitative differences between him and other minimally verbal children in the previous study. The possibility was explored that there is a point or threshold along the developmental continua for social cognition and speech sound production that allows for expansion into useful language.
Grundsätze der Falldokumentation in der Homöopathie
Authors: Bleul Gerhard
Published: June 2020

Kriterien der Falldokumentation für die gesamte Medizin und speziell für die Homöopathie wurden in mehreren Konsensus-Konferenzen und Arbeitsgruppen konzipiert. Die wichtigsten Entwicklungen der letzten 2 Jahrzehnte sind in diesem Artikel zusammengefasst.
Returning to Play after Prolonged Training Restrictions in Professional
Collision Sports
Authors: Stokes Keith A. , Jones Ben , Bennett Mark , Close Graeme L. , Gill Nicholas , Hull James H. , Kasper Andreas M. , Kemp Simon P.T. , Mellalieu Stephen D. , Peirce Nicholas , Stewart Bob , Wall Benjamin T. , West Stephen W. , Cross Matthew
Published: June 2020

The COVID-19 pandemic in 2020 has resulted in widespread training disruption in many
sports. Some athletes have access to facilities and equipment, while others have
limited or no access, severely limiting their training practices. A primary concern
is that the maintenance of key physical qualities (e. g. strength, power,
high-speed running ability, acceleration, deceleration and change of direction),
game-specific contact skills (e. g. tackling) and decision-making ability,
are challenged, impacting performance and injury risk on resumption of training and
competition. In extended periods of reduced training, without targeted intervention,
changes in body composition and function can be profound. However, there are
strategies that can dramatically mitigate potential losses, including resistance
training to failure with lighter loads, plyometric training, exposure to high-speed
running to ensure appropriate hamstring conditioning, and nutritional intervention.
Athletes may require psychological support given the challenges associated with
isolation and a change in regular training routine. While training restrictions may
result in a decrease in some physical and psychological qualities, athletes can
return in a positive state following an enforced period of rest and recovery. On
return to training, the focus should be on progression of all aspects of training,
taking into account the status of individual athletes.
Artroplastia de ombro: tenotomia do subescapular versus osteotomia do tubérculo menor
Authors: França Flávio Oliveira , Freitas José Márcio Alves , Mariosa Carlos Alberto Menezes , Bastiani Carlos Eduardo , Godinho Glaydson Gomes
Published: June 2020

Objetivo Avaliar e comparar a função do músculo subescapular entre os grupos submetidos a tenotomia do subescapular (Grupo A) e osteotomia do tubérculo menor (Grupo B), em pacientes tratados por artroplastia anatômica total e parcial de ombros apresentando osteoartrose primária.

Métodos Estudo retrospectivo de pacientes portadores de osteoartrose primária glenoumeral tratados cirurgicamente com prótese anatômica total ou parcial de ombro, avaliados por exame clínico, exames de imagens, escala visual analógica de dor e escore funcional de Constant e Murley. Foram avaliados 28 pacientes, totalizando uma amostra de 32 ombros operados. O seguimento mínimo foi de 12 meses (média 47,45 meses).

Resultados Nos pacientes submetidos à tenotomia do tendão subescapular, dez obtiveram resultado ultrassonográfico com ruptura de sua espessura total (56%). A consolidação ocorreu em todos pacientes submetidos a osteotomia do tubérculo menor. Não houve diferença entre os grupos na comparação do teste Lift Off, da força nos testes Belly Press e Bear hug, e no escore de Constant e Murley.

Conclusões Não encontramos diferença entre os grupos A e B na comparação do teste Lift Off, da força nos testes Belly Press e Bear hug, e no escore de Constant e Murley.
Luxação traumática isolada da articulação trapézio-metacárpica - Relato de dois casos clínicos
Authors: Pires Filipa Porto , Monteiro Eurico Lisboa , Oliveira Filipa , Carvalho Pedro Atilano , Teixeira João Pedro , Miranda António
Published: June 2020

A luxação traumática isolada da articulação trapézio-metacárpica é uma lesão rara que faz parte de menos de 1% de todas as lesões de mãos.

Os autores apresentam dois casos de luxação traumática isolada da articulação trapézio-metacárpica. Um dos casos foi tratado com redução fechada e imobilização com gesso, e o outro foi tratado com redução fechada, fixação com fios Kirschner, e imobilização com gesso.

O primeiro paciente teve um bom resultado funcional e não mostrou sinais de instabilidade trapeziometacarpal. O paciente tratado com fios Kirschner apresentou sinais de instabilidade clínica e subluxação radiológica.

A luxação isolada da articulação trapeziometacarpal é uma lesão rara que pode causar instabilidade articular que interfere com a funcionalidade normal da mão e pode resultar em mudanças articulares degenerativas.

O melhor manejo dessa lesão ainda é controverso, já que ainda faltam evidências na literatura que mostrem a superioridade de um tratamento em relação ao outro.
Sequentially Catalyzed Three-Component Masuda–Suzuki–Sonogashira Synthesis of Fluorescent 2-Alkynyl-4-(7-azaindol-3-yl)pyrimidines: Three Palladium-Catalyzed Processes in a One-Pot Fashion
Authors: Müller Thomas J. J. , Drießen Daniel , Biesen Lukas
Published: June 2020

The Masuda–Suzuki–Sonogashira sequence efficiently unites, in a one-pot fashion, a borylation, an arylation, and an alkynylation in the sense of a sequentially Pd-catalyzed three-component reaction to give fluorescent 2-alkynyl-4-(7-azaindol-3-yl) pyrimidines in yields of 24–83% (14 examples). Time-dependent density-functional theory calculations supported the electronic structure of the longest wavelength absorption bands, revealing that this novel consecutive three-component synthesis opens an efficient access to alkynyl meriolins, a novel class of potential inducers of apoptosis.
Analysis of Conization Results in Patients undergoing Hysterectomy for Uterine Adenocarcinoma
Authors: Drumond Denise Gasparetti , Leite Isabel Cristina Gonçalves , Rodrigues Vivian de Oliveira , Pannain Gabriel Duque , Carvalho Miralva Aurora Galvão , Amaral Renata Guimarães Rabelo do
Published: June 2020

Objective To observe if the histopathological result of a conization performed after cervical adenocarcinoma in situ diagnosis is compatible with the histopathological analysis of a subsequent hysterectomy.

Methods The present descriptive and observational research consisted of the analysis of the medical records of 42 patients who were diagnosed with in situ adenocarcinoma postconization. The analysis consisted of whether there was compatibility between the histopathological reports of conization and hysterectomy and if there was an association between adenocarcinoma in situ and another neoplasia (squamous disease). Interpretation of any immunohistochemistry reports obtained was also performed. In addition, clinical and epidemiological data were also analyzed.

Results A total of 42 conizations were performed, 33 (79%) were cold knife conizations and 9 (21%) were loop electrosurgical excision procedures (LEEPs). Of the patients analyzed, 5 (10%) chose not to undergo subsequent hysterectomy to preserve fertility or were < 25 years old. Out of the 37 patients with adenocarcinoma in situ who underwent subsequent hysterectomy, 6 (16%) presented with residual disease. This finding proved incompatible with the finding of the conizations, which had ruled out invasive cancer.

Conclusion The prevalence of adenocarcinoma in situ increased in the past years. There is still a large part of the medical literature that advocates the use of conservative treatment for this disease, even though it is common knowledge that it is a multifocal disease. However, the majority of studies advocate that hysterectomy should remain the preferred treatment for women who have already completed their reproductive purpose.
Osteoartrite do tornozelo
Authors: Godoy-Santos Alexandre Leme , Fonseca Lucas Furtado , de Cesar Netto Cesar , Giordano Vincenzo , Valderrabano Victor , Rammelt Stefan
Published: June 2020

A osteoartrite (OA) é caracterizada por uma degradação crônica, progressiva e irreversível da superfície articular, associada a inflamação articular. A principal etiologia da OA do tornozelo é pós-traumática e sua prevalência é maior entre os jovens e obesos. Apesar dos avanços no tratamento das fraturas ao redor do tornozelo, o risco geral de desenvolver OA pós-traumática do tornozelo após 20 anos do trauma é de quase 40%; especialmente nas fraturas bimaleolares de Weber tipo B e C e fraturas envolvendo a borda tibial posterior. Nas fraturas do tálus, essa prevalência se aproxima de 100%, dependendo da gravidade da lesão e do tempo de seguimento. Nesse cenário, é fundamental a compreensão atual das vias de sinalização moleculares envolvidas na senescência e apoptose dos condrócitos. O tratamento da OA do tornozelo é estagiado e guiado pelos sistemas de classificação, condições locais e do paciente. Os principais problemas são a limitada capacidade de regeneração da cartilagem articular, o baixo suprimento de sangue e a escassez de células-tronco progenitoras.

A presente atualização resume evidências científicas básicas recentes da OA pós-traumática do tornozelo, com foco principal nas alterações metabólicas da sinóvia, da cartilagem e do líquido sinovial. Epidemiologia, fisiopatologia, implicações clínicas, e opções de tratamento são também discutidas.
Role of Ultrasound in Neurocritical Care
Authors: Bhatt Rashmi , Khanna Puneet
Published: June 2020

Bedside point of care ultrasound has acquired an extremely significant role in diagnosis and management of neurocritical care, just as it has in other specialties. Easy availability and increasing expertise have allowed the intensivists to use it in a wide array of situations, such as confirming clinical findings as well as for interventional and prognostic purposes. At present, the clinical applications of ultrasonography (USG) in a neurosurgical patient include estimation of elevated intracranial pressure (ICP), assessment of cerebral blood flow (CBF) and velocities, diagnosis of intracranial mass lesion and midline shifts, and examination of pupils, apart from the systemic applications. Transcranial sonography has also found use in the diagnosis of the cerebral circulatory arrest. An increasing number of clinicians are now relying on the use of ultrasound in the neurointensive care unit for neurological as well as non-neurological indications. These uses include the diagnosis of shock, respiratory failure, deep vein thrombosis and performing bedside procedures.
Different Perceptions among Women and Their Physicians Regarding Contraceptive Counseling: Results from the TANCO Survey in Brazil
Authors: Machado Rogério Bonassi , Ushikusa Thaís Emy , Monteiro Ilza Maria Urbano , Guazzelli Cristina Aparecida Falbo , di Bella Zsuzsanna Jarmy , Politano Carlos Alberto , Sakamoto Luís Carlos
Published: June 2020

Objective The optimal use of contraceptive methods requires that women participate in targeted choice of methods that meet their individual needs and expectations. The Thinking About Needs in Contraception (TANCO) study is a quantitative online survey of the views of health professionals and women on aspects of contraceptive counseling and contraceptive use.

Methods Physicians and women attending clinics for contraception were invited to complete online questionnaires. The research explored the knowledge and use of contraceptive methods, satisfaction with the current method and interest in receiving more information on all methods. Aspects related to contraceptive practice among physicians were gathered in parallel. The results obtained in the Brazilian research were compared with those of the European research, which involved 11 countries.

Results There was a high prevalence of contraceptive use and general satisfaction with the current method. A total of 63% of the women were using short-acting contraceptive (SAC) methods, and 9% were using a long-acting reversible contraceptive (LARC). Sixty-six percent of women were interested in receiving more information on all methods; 69% of women said they would consider LARC if they received more comprehensive information about it. Health professionals tend to underestimate the interest of women in receiving information about contraception in general, and more specifically about LARCs.

Conclusion Despite the high levels of use and satisfaction with the current methods, women were interested in receiving more information on all contraceptive methods. Structured contraceptive counseling based on individual needs and expectations may lead to greater knowledge and a greater likelihood of proper contraceptive choice.
Reading Epilepsy—An Interesting Case Report
Authors: Hadi Mohammed S. , Rao Arjuna , Vooturi Sudhindra , Jayalakshmi Sita
Published: June 2020

Reading epilepsy is a language induced reflex epilepsy with common ictal manifestations of regional myoclonus. The electroencephalogram (EEG) often shows focal, regional, or generalized discharges, rarely there may not be any associated EEG changes. We report case of a 25-year-old male with three episodes of seizures, precipitated while reading a book. Reported semiology was stuttering while reading with jerking of tongue as perceived by the patient followed by generalized tonic–clonic seizures (GTCS). Magnetic resonance imaging (MRI) of brain with 3 Tesla (3T) was normal. During videoelectroencephalogram (vEEG), reading precipitated recurrent stuttering each lasting for 1 to 2 seconds. Corresponding vEEG showed rhythmic 1/second symmetrical generalized spike and wave discharges lasting for 2 to 4 seconds during episodes of stuttering with intervening normal background activity, followed by generalized spike and wave discharges intermixed with artifacts recorded during secondary generalization. Patient was prescribed levetiracetam and responded well and is currently seizure-free for more than 6 years.
Simple practical system for directly measuring magnetocaloric effects under large magnetic fields
Authors: Liu J. Y. , Zheng Z. G. , Lei L. , Qiu Z. G. , Zeng D. C.
Published: June 2020

Direct measurements of the adiabatic temperature change (ΔTad) in Gd and Mn1.15Fe0.8P0.5Si0.5C0.05 are made using a homemade adiabatic magnetocalorimeter at 260–360 K and 0–7 T. The system uses a servo motor to drive the samples into and out of the magnetic field under a vacuum environment provided by the Physical Property Measurement System (PPMS). The peak values of ΔTad for Gd and Mn1.15Fe0.8P0.5Si0.5C0.05 at 7 T are 8.71 K and 6.41 K at ambient temperatures of 303 K and 317 K, respectively. Based on the theory model, it is found that ΔTad of Gd depends on the 2/3 exponential function of magnetic field H (ΔTad ∝ H2/3), whereas the Mn1.15Fe0.8P0.5Si0.5C0.05 compound follows the power law of ΔTad ∝ H0.66–1.04 due to the first order magnetic transitions. Furthermore, using the constructed experimental instrument, the adiabatic temperature change in different magnetic materials, including materials with first/second order magnetic transition and blocks, flakes, or powders, can be directly measured under large magnetic fields and wide temperature spans.