bluuebunny/crossref_metadata_2025 huggingface dataset:
Polarization effects of hot nuclear matter on the fusion of heavy ions
Authors: Gharaei R. , Sani S. Ramezani , Aliabad H. A. Rahnamaye
Published: September 2024

Within the framework of the modified density-dependent Seyler–Blanchard approach in the [Formula: see text] approximation, the polarization effects of hot nuclear matter (PEHNM) are investigated on the fusion process of 16 different colliding systems in the mass range [Formula: see text]. In order to calculate the nucleus–nucleus potential, we use the double-folding (DF) model supplemented with the thermal effects of compound nucleus and also a repulsive potential that takes into account the incompressibility of the nuclear matter. The calculations of the fusion cross-sections are performed based on the couplings to the low-lying [Formula: see text] and [Formula: see text] vibrational states in both target and projectile. The sensitivity of sub-barrier fusion cross-sections to the polarization effects is evident from this study. The obtained results reveal that the modified form of the DF potential in the presence of the PEHNM appropriately reproduces the energy-dependent behavior of the experimental fusion cross-sections for the studied reactions. The role of the polarization effects on the fusion barriers as well as the inner part of the potential is also discussed.
Re-Centering the Community in Violence Intervention: Reclaiming Legacies of Street Outreach in the Provision of Public Safety
Authors: Hureau David M. , Papachristos Andrew V.
Published: September 2024

Cities across the country have increasingly turned toward community violence interventions (CVI) to address community safety without relying on criminal legal strategies. This article inspects beneath the veneer of present-day CVI approaches to examine how their work is dedicated as much to neighborhood social organization as it is to responding to gun violence. Underneath contemporary definitions of outreach workers as mediators of violence, earlier sociologists and criminologists conceived of these workers as frontline builders of community charged with mending breaks in the social fabric. Acknowledging this past is important because it re-centers criminology's contributions to the practice of street outreach and provides insights that help to comprehend the challenging present moment in American public safety. We offer directions for a reinvigorated social science of street outreach that re-centers community processes, structures, and institutions and, in so doing, might better inform contemporary practice and policy.
Progression of Bone Marrow Lesions and the Development of Knee Osteoarthritis: Osteoarthritis Initiative Data
Authors: Moradi Kamyar , Mohammadi Soheil , Roemer Frank W. , Momtazmanesh Sara , Hathaway Quincy , Ibad Hamza Ahmed , Hunter David J. , Guermazi Ali , Demehri Shadpour
Published: September 2024

Longitudinal increase in bone marrow lesion volume measured using an artificial intelligence algorithm on serial MRI scans was predictive of developing radiographic knee osteoarthritis.
Role of Graphene in Next-Generation Electrochemical Energy Storage Systems: Insights and Innovations
Authors: Singh Kamaljit , Trabelsi Youssef , Mahajan Priyanka , Khanna Virat
Published: September 2024

There is a rising demand for energy storage systems (ESS) that are both environmentally sustainable and high-performing. To meet the prerequisites of diverse energy-consuming applications, developing novel, better-quality and highly-performing electrode materials for ESS is vital. In this quest, graphene emerges as a wonder material, ascribed to its unmatched mechanical, electrical and thermal behaviour. Different ESS can be significantly developed with enhanced energy storage capacity with the application of graphene. Herein, a brief discussion of the structure and synthesis techniques for graphene and its derivatives is presented. In addition to this, the study also offers a comprehensive summary on the latest developments in lithium-ion batteries, double-layer supercapacitors, pseudo capacitors and hybrid supercapacitors using graphene as the dominant material for anode/cathode electrodes in the form of composites and hybrids. The effect of the graphene on the performance metrics of the EESS has also been imparted. Despite the promising advancements, the key challenges and limitations in the development of graphene-based high-performing energy storage devices are described in detail. The article concludes with the potential prospects of energy storage using graphene are also discussed.
3D Monitoring Model for Real‐Time Displacement of Metro Tunnel under “Dual Carbon” Background
Authors: Chai Jianyong , Jia Limin , Cao Jian , Liu Jianfeng , Chen Zhe , Li Shubin , Wang Xuejuan , Han Hong
Published: September 2024

Real‐time automatic displacement monitoring of metro tunnels is vital for ensuring operational safety and contributes to carbon reduction goals by improving system efficiency. This study focuses on key monitoring elements such as displacement, settlement, convergence, and cracking. Through the analysis of continuous monitoring data, a real‐time displacement monitoring model for metro tunnels based on robotic total stations is proposed. This model can timely identify potential risks, thereby ensuring the safe operation of tunnels and reducing carbon emissions from unnecessary maintenance operations, thereby reducing the carbon footprint of metro operations. This article takes the Jinan Metro Tunnel Displacement Real‐time Monitoring Project in China as a case study and constructs a comprehensive monitoring framework using robotic total stations, intelligent automated deformation monitoring data collectors, and cloud servers. The implementation details of the project, displacement monitoring principles, monitoring system construction, and data analysis processes are elaborated in detail. Taking the monitoring data of Jinan Metro Line 2 from April 1, 2022, to May 31, 2023, as an example, the results show that the tunnel displacement is within the safe range, verifying the practical application value of the method proposed in this paper. It can effectively ensure the safe operation of the metro and promote sustainable development and low‐carbon metro construction.
Anomaly‐Based Intrusion Detection System in Wireless Sensor Networks Using Machine Learning Algorithms
Authors: Al-Fuhaidi Belal , Farae Zainab , Al-Fahaidy Farouk , Nagi Gawed , Ghallab Abdullatif , Alameri Abdu
Published: September 2024

One of the most significant issues in wireless sensor networks (WSNs) is security, which must be addressed to keep WSNs safe from malicious attacks. An intrusion detection system (IDS) is essential in analyzing network traffic and detecting abnormal events. However, these IDSs suffer from several drawbacks that affect their effectiveness and flexibility in accuracy, so they must overcome these drawbacks to improve the performance of IDS. These drawbacks include difficulties in determining the appropriate dataset, the problem of feature selection, and the issue of the imbalanced dataset and choosing the appropriate algorithms for the classification process in WSN. In this paper, a model for an anomaly‐based IDS in WSNs is proposed. This model applied mutual information (MI) for feature selection and the synthetic minority oversampling technique (SMOTE) for solving the imbalanced dataset problem. It used different machine learning (ML) algorithms, random forest (RF), decision tree (DT), support vector machine (SVM), and K‐nearest neighbors (KNNs) to analyze network traffic and binary classification or multiclass classification. To implement and evaluate the performance of the proposed model, the standard dataset NSL‐KDD is used. Python language is used to implement the proposed model in the Anaconda platform, and many evaluation metrics are also utilized to evaluate the performance of the proposed method. Experimental results show that the proposed model can detect intrusions using different ML algorithms with high accuracy. The results of the proposed model for different ML algorithms outperform the state‐of‐the‐art algorithms, and the maximum enhancement reached 15% in the accuracy metric.
Development and Evaluation of Calorie‐Reduced Functional Cookies Enriched With Date Press Cake
Authors: Alqahtani Nashi K. , Alnemr Tareq M. , Almadhi Faisal H. , Aboufarrag Hassan T.
Published: September 2024

Date press cake (DPC) is a by‐product of date syrup (also known Dips) production with high nutritional content. However, it is still underutilized owing to the lack of knowledge about its health benefits and possible food applications. Therefore, the aim of the study was to prepare low‐calorie fibre‐rich functional cookies fortified with DPC. Different additions of DPC (5% and 10% on wheat flour basis) were added while sugar was reduced by 25% and 50% and replaced by 0.39 and 0.65 g Stevia, respectively. Cookies were analysed for their physicochemical and sensory attributes. The obtained results showed that moisture content, ash, and dietary fibre content significantly (p < 0.05) increased with increasing DPC amount, while sucrose content decreased significantly in treatments compared to the control. In addition, the hardness of 10% DPC‐enriched cookies with 50% sugar reduction was slightly significantly higher than the control, while other treatments were not significantly different. The addition of DPC significantly decreased both L∗ and b∗, while increasing a∗ of cookies. The results also revealed that the diameter, thickness, and spread ratio of the DPC‐enriched cookies did not significantly differ from those of the control sample. On the other hand, the inclusion of DPC and Stevia significantly lowered the weight before baking of cookies, while the baking loss did not significantly change, apart from cookies with 5% DPC and 50% sugar reduction which showed a slight significant increase. The sensory evaluation results showed that cookies with 10% DPC inclusion and 25% sugar reduction received the highest appearance, texture, flavour, and overall acceptability scores compared to the control. However, the differences were not significant. These results indicate that the incorporation of DPC as a low‐cost fibre‐rich ingredient in cookies, along with the sugar reduction and Stevia substitution, improved the fibre content and nutritional value of cookies without compromising their physical or sensory attributes.
Chitosan‐Based Hemostatic Pad Reduced Vascular Complications After Transradial Coronary Intervention in Uncontrolled Hypertensive Patients: Application of Chitosan‐Based Hemostatic Pad on CAG or PCI
Authors: Qian Lu , Cao Ming-Qiang , Feng Ze-Xiong , Zou Cao , Sun Si-Jia , Hu Sheng-Da
Published: September 2024

Background: Vascular complications after coronary angiography (CAG) or percutaneous coronary intervention (PCI) are a major concern for revascularization therapies. In this study, we investigated whether the application of a chitosan‐based hemostatic pad (HP) could ameliorate vascular complications after CAG or PCI procedures.

Methods: We retrospectively analyzed patients undergoing CAG or PCI in our cardiovascular center from January 2019 to December 2021. The incidence of total vascular complications including errhysis, large hematoma, pseudoaneurysm, radial artery occlusion (RAO), blister, and pain was recorded. Subgroup analyses of patients with a history of hypertension, patients with uncontrolled hypertension, and patients with controlled hypertension were performed.

Results: Our results demonstrated that the application of chitosan‐based HP had no effect on vascular complications after CAG or PCI procedures (odds ratio [OR]: 1.03 (0.84–1.26), p = 0.80). Nevertheless, chitosan‐based HP treatment markedly decreased the incidence of vascular complications in uncontrolled hypertensive patients (OR: 0.32 (0.11–0.95), p = 0.04), but not in hypertensive patients with controlled blood pressure (BP) (OR: 1.09 (0.88–1.35), p = 0.42).

Conclusions: Chitosan‐based HP treatment could reduce the incidence of vascular complications in patients with uncontrolled hypertension. Nonetheless, applying chitosan‐based HP treatment after CAG or PCI procedures is not recommendable for controlled hypertensive patients.
Prevalence of Gastrointestinal Parasitic Infections and Associated Risk Factors Among Secondary School Students in Wonji Shoa, Adama District, East Shoa Zone, Oromia Region, Ethiopia
Authors: Adugna Abera , Yohannes Tilahun , Tesfaye Solomon
Published: September 2024

Intestinal parasitic infections (IPIs) remain a significant contributor to morbidity and mortality globally, particularly in developing countries such as Ethiopia. Periodic assessments of IPI prevalence are essential prerequisite for effective control measures. Therefore, this cross‐sectional study is aimed at determining the prevalence of gastrointestinal parasitic infections and associated risk factors among schoolchildren at Wonji Shoa Secondary School, East Shoa Zone, Adama district, Oromia region, Ethiopia, between January and June 2022. A simple random stratified sampling technique was employed to select participants. Sociodemographic and risk factor data were collected using a structured questionnaire. Stool samples were examined to identify parasites. Data were analyzed using SPSS version 20. Descriptive statistics, chi‐square tests, and logistic regression were conducted to assess associations between variables and then the strength of the association. A p value < 0.05 was considered statistically significant. Of the 403 selected students, 330 completed the study that makes 81.89% response success. The overall IPI prevalence was 16.66% (55/330), with a higher prevalence among males (60%, 33/55) than females (40%, 22/55). Five parasite species were identified: two protozoa (Entamoeba histolytica and Giardia lamblia) with a combined prevalence of 9.70% (32/330) and three helminths (Ascaris lumbricoides, Hymenolepis nana, and Taenia spp.) with a combined prevalence of 6.97% (23/330). Cysts were detected in 62.5% of E. histolytica cases (15/24), and eggs were detected in 76.92% of A. lumbricoides cases (10/13). The study revealed a substantial IPI prevalence (16.66%) among the students. This finding underscores the need for effective prevention and control strategies. The predominance of parasitic infections among males is notable requiring further investigation of the factors. The identification of multiple parasite species indicates a complex epidemiological scenario. The presence of protozoan cysts and helminthic eggs highlights the potential for fecal‐oral transmission and the importance of improved sanitation and hygiene practices.
Ideal Parameter Estimation of Photocatalysis Process to Boost Amoxicillin Degradation Efficiency Using Marine Predators Optimization Algorithm
Authors: Hassan Mohamed K. , Cotfas Daniel T. , Rezk Hegazy , Youssef H. , Shehata Ahmed S. , El-Bary Alaa A.
Published: September 2024

This paper presents a methodology for determining the optimal parameters of a photocatalysis process for treating pharmaceutical wastewater. Three parameters are considered: pH value, catalyst dosages, and reaction time to boost the amoxicillin degradation efficiency (ADE). The proposed methodology contains two stages: fuzzy modelling and a parameter determination process using the marine predators algorithm (MPA). Firstly, based on the experimental dataset of ADE in terms of pH value, catalyst dosages, and reaction time, a robust fuzzy model is produced to model the photocatalysis/ozonation process. The target is reducing the root mean square error (RMSE) between the actual data and the experimental dataset. Using fuzzy, the RMSE decreased from 2.0248 using ANOVA to 0.3148 using fuzzy (decreased by 84%). Next, using the MPA, the optimal parameters of pH value, catalyst dosages, and reaction time corresponding to maximum ADE are determined. The suggested strategy boosted the ADE from 88.23% to a rate of 11.68% compared with the experimental and RSM approaches. Under this condition, the optimal solutions are 11, 384 mg/L, and 33.615 min, respectively, for pH, catalyst dosages, and reaction time.
A Case of Rapidly Progressive De Novo Metastatic Small‐Cell Neuroendocrine Prostate Cancer
Authors: Dalal Aryan , Clark-Garvey Sean , Gdowski Andrew , Zhang Sophia , Wobker Sara E. , Rowe Steven P. , Altun Ersan , Beltran Himisha , Milowsky Matthew I.
Published: September 2024

Introduction: Neuroendocrine/small‐cell prostate cancer (NEPC) is a rare and aggressive subtype of prostate cancer, which typically develops after prolonged treatment for metastatic castration‐resistant disease, but can, less commonly, occur de novo.

Case Presentation: We describe a case of de novo NEPC in a tumor with mixed pathology including acinar adenocarcinoma and neuroendocrine/small‐cell carcinoma with rapid progression of metastatic disease. Despite initiation of treatment with androgen deprivation therapy (ADT) and chemotherapy, the patient continued to exhibit progression leading to multiple complications including a large bowel obstruction and ultimately progressive hepatic metastases resulting in liver failure.

Conclusion: This case illustrates the clinical presentation and highly aggressive nature of de novo NEPC. Recognizing atypical clinical progression in prostate cancer is critical for the detection of NEPC; however, despite early identification and initiation of treatment, the prognosis remains poor, thus highlighting the need for further study into NEPC biology and novel therapeutic approaches.
Job Crafting and Resilience among Medical Interns: The Moderating Role of Social Media Use Intensity
Authors: Yang Dan , Cao Zhe
Published: September 2024

COVID‐19 brought many difficulties for medical workers’ mental health. They tend to exhibit a high turnover rate, which has deteriorated the situation of high demands on the healthcare workforce. Thus, enhancing medical interns’ resilience is of great significance. Previous studies have delved into how job crafting relates to resilience, but there has been limited exploration of how the three dimensions of job crafting interplay with resilience. Thus, our research examined the moderating role of social media use intensity in associations between task crafting, cognitive crafting, relational crafting, and resilience. A total of 605 medical interns were obtained. The results revealed that task crafting, cognitive crafting, and relational crafting exhibited significant and positive associations with resilience. More importantly, social media use intensity moderated associations between task crafting, cognitive crafting, and resilience, with these associations being weaker for individuals with high levels of social media use intensity. However, the moderating role of social media use intensity was not significant between relational crafting and resilience. Finally, the findings provided some guidance for instructors to enhance medical interns’ resilience and thus prepare them for employment.
Prevalence, Antibiotic Susceptibility Pattern and Associated Factors of Streptococcus pyogenes among Pediatric Patients with Acute Pharyngitis in Sidama, Southern Ethiopia
Authors: Gebre Alemitu Beyene , Fenta Demissie Assegu , Negash Abel Abera , Hayile Betelihem Jima
Published: September 2024

Background. Streptococcus pyogenes is the most frequent cause of pharyngitis and skin infections in children and causes immune complications like rheumatic fever and rheumatoid heart disease (RHD), particularly in developing countries like Ethiopia. The aim of this study was to determine the prevalence, antibiotic resistance pattern, and associated factors of Streptococcus pyogenes among pediatric patients suspected of acute pharyngitis in Sidama Region, Southern Ethiopia. Methods. A cross‐sectional study was conducted on 213 acute pharyngitis suspected pediatric patients from April to September 2022 at Hawassa University Compressive Specialized Hospital and Yirgalem Hospital. Sociodemographic and clinical data were collected using a structured questionnaire. A throat swab was cultured to isolate S. pyogenes, and antimicrobial susceptibility testing was done using standard bacteriological techniques. Data were analyzed using SPSS version 25, and P value of <0.05 was considered as statistically significant. Result. Out of 213 throat swabs cultured, 22 (10.3%) with 95% CI (6.6–14.6%) were S. pyogenes positive. All isolates of S. pyogenes were sensitive to penicillin and amoxicillin. In contrast, 8 (36.4%) isolates exhibited resistance to tetracycline, 7 (31.8%) to ceftriaxone, 6 (27.3%) to erythromycin, and 5 (22.7%) isolates showed multidrug resistance. The presence of palatal petechiae (P = 0.037) and tonsillar swelling or exudate (P = 0.007) were significantly associated with S. pyogenes carriage in children suspected of having acute pharyngitis. Conclusion. In this study, the prevalence of S. pyogenes among children suspected with acute pharyngitis was low compared to other studies. The isolates showed a high level of resistance to commonly used antibiotics. Therefore, the treatment of pediatric acute S. pyogenes pharyngitis should depend on an antimicrobial susceptibility test. Furthermore, evaluation of S. pyogenes pediatric acute pharyngitis risk factors and tracking of antibiotic resistance are crucial in the controlling of pediatric acute S. pyogenes pharyngitis.
Precise In Situ Delivery of a Photo-Enhanceable Inflammasome-Activating Nanovaccine Activates Anticancer Immunity
Authors: Zhou Yang , Pang Li , Ding Tao , Chen Kang , Liu Jinzhao , Wu Meicen , Wang Weiping , Man Kwan
Published: September 2024

A variety of state-of-the-art nanovaccines (NV) combined with immunotherapies have recently been developed to treat malignant tumors, showing promising results. However, immunosuppression in the tumor microenvironment (TME) restrains cytotoxic T-cell infiltration and limits the efficacy of immunotherapies in solid tumors. Therefore, tactics for enhancing antigen cross-presentation and reshaping the TME need to be explored to enhance the activity of NVs. Here, we developed photo-enhanceable inflammasome-activating NVs (PIN) to achieve precise in situ delivery of a tumor antigen and a hydrophobic small molecule activating the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain–containing protein 3 inflammasome (NLRP3) pathway. Near-infrared light irradiation promoted PIN accumulation in tumor sites through photo-triggered charge reversal of the nanocarrier. Systematic PIN administration facilitated intratumoral NLRP3 inflammasome activation and antigen cross-presentation in antigen-presenting cells upon light irradiation at tumor sites. Furthermore, PIN treatment triggered immune responses by promoting the production of proinflammatory cytokines and activating antitumor immunity without significant systematic toxicity. Importantly, the PIN enhanced the efficacy of immune checkpoint blockade and supported the establishment of long-term immune memory in mouse models of melanoma and hepatocellular carcinoma. Collectively, this study reports a safe and efficient photoresponsive system for codelivery of antigens and immune modulators into tumor tissues, with promising therapeutic potential.

Significance: The development of a photoresponsive nanovaccine with spatiotemporal controllability enables robust tumor microenvironment modulation and enhances the efficacy of immune checkpoint blockade, providing an effective immunotherapeutic strategy for cancer treatment.

See related commentary by Zhen and Chen, p. 3709
Construction and Validation of a Novel Forecasting Nomogram to the Risk of Colorectal Adenomas: Preventing Colorectal Cancer at Its Origin
Authors: Li Mao , Cui Mingyu , Zhou Xiaobin , Song Ying
Published: September 2024

Colorectal adenomas are responsible for the origin of most colorectal cancers. Early detection together with active intervention of colorectal adenomas plays a crucial role in the prevention of colorectal cancer. This study aimed to construct and validate a new nomogram for the forecasting of the risk of colorectal adenomas based on lifestyle risk factors that could offer potential benefits for colorectal cancer prevention. Colonoscopy reports, pathology reports, physical factors, family history, personal history of disease, diet, and lifestyle habits were collected from 1,133 subjects who underwent complete colonoscopy. All subjects were divided into the training cohort (n = 792) and the validation cohort (n = 341). A nomogram predicting the risk of colorectal adenoma development was constructed using the training cohort, and the C-index was calculated. The predictive accuracy and clinical applicability of the nomogram were verified in the validation cohort. The nomogram was constructed by six statistically significant variables selected from 18 health factors, including advanced age, male, smoking, drinking, pickles, and irregular defecation. The C-index of the training cohort was 0.778, and the C-index of the validation cohort was 0.754. The calibration curve and decision curve analysis also confirmed that the model has good predictive ability and high profit. The nomogram constructed in this study was validated and can be applied to predicting the occurrence risk of colorectal adenoma. The model can guide the identification of patients with nonsymptomatic colorectal adenomas and the recognition of high-risk individuals for whom colonoscopy is advisable.

Prevention Relevance: Colorectal adenomas are the origin of most colorectal cancers. In this research, we explored the risk factors of colorectal adenomas and constructed a colorectal adenoma risk prediction nomogram in the expectation of early detection of patients with nonsymptomatic colorectal adenoma and advocated for their aggressive treatment to achieve colorectal cancer prevention.
Supplementary Figure 2 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Kaplan Meier curves in MIBC cohort A) Overall Survival and B) Relapse Free Survival (RFS)
Figure 1 from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

Flow cytometry of CD38+ immune cells from serially collected blood samples. A, mRCC cohort. B, MIBC cohort. C, NK cells in the mRCC cohort. D, NK cells in the MIBC cohort. EOT, end of treatment; PD3, predose 3; PD4, predose 4; PD7, predose 7; PD8, predose 8; Pre, pretreatment; PS, post–tissue collection.
Figure S8 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

NMTi treatment induces features of parthanatos in vitro and in vivo.
Figure S12 from N-Myristoytransferase Inhibition Causes Mitochondrial Iron Overload and Parthanatos in TIM17A-Dependent Aggressive Lung Carcinoma
Authors: Geroyska Sofia , Mejia Isabel , Chan Alfred A. , Navarrete Marian , Pandey Vijaya , Kharpatin Samuel , Noguti Juliana , Wang Feng , Srole Daniel , Chou Tsui-Fen , Wohlschlegel James , Nemeth Elizabeta , Damoiseaux Robert , Shackelford David B. , Lee Delphine J. , Díaz Begoña
Published: September 2024

Effect of lipid peroxidation on the abundance of TIM17A in lung carcinoma cells.
Table S1 from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

Antibodies
Supplementary Data from Tumor-Intrinsic Activity of Chromobox 2 Remodels the Tumor Microenvironment in High-grade Serous Carcinoma
Authors: Iwanaga Ritsuko , Yamamoto Tomomi M. , Gomez Karina , Nguyen Lily L. , Woodruff Elizabeth R. , Post Miriam D. , Mikeska Railey G. , Danis Etienne , Danhorn Thomas , Boorgula Meher P. , Mitra Siddhartha S. , Marjon Nicole A. , Bitler Benjamin G. , Brubaker Lindsay W.
Published: September 2024

Overview of supplementary data
Supplementary Table 4 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

Distribution of immune cells and tumor cells across different histologies in the malignant mesothelioma (MM) cohort.
Supplementary Figure 2 from Spatial Landscape of Malignant Pleural and Peritoneal Mesothelioma Tumor Immune Microenvironments
Authors: Ma Xiaojun , Lembersky David , Kim Elena S. , Becich Michael J. , Testa Joseph R. , Bruno Tullia C. , Osmanbeyoglu Hatice U.
Published: September 2024

MM intra-tumor heterogeneity and survival analysis. (A) Comparison of TMA core cell-type proportions within patients and across patients. Each value in the boxplot represents the Pearson correlation coefficients between cell-type proportions across cores from different patients and cores within individual patients. (B) Kaplan-Meier survival curves of MM patients that categorized into two groups based on intra-tumor heterogeneity: those with high intra-tumor heterogeneity (Shannon entropy > 0.6 quantile) shown in blue, and those with low intra-tumor heterogeneity (Shannon entropy < 0.4 quantile) depicted in yellow.
Data from A Pilot Study of the CD38 Antagonist Daratumumab in Patients with Metastatic Renal Cell Carcinoma or Muscle-Invasive Bladder Cancer
Authors: Campbell Matthew T. , Shah Amishi Y. , Msaouel Pavlos , Tannir Nizar M. , Siefker-Radtke Arlene O. , Kamat Ashish M. , Navai Neema , Dinney Colin P.N. , Rao Priya , Guo Charles C. , Sheth Rahul A. , Venkatesan Aradhana M. , Tidwell Rebecca S. , Yadav Shalini S. , Gu Aidi , Chen Hong , Macaluso Marc , Duan Fei , Basu Sreyashi , Jindal Sonali , Sharma Padmanee
Published: September 2024

AbstractPurpose:
We performed a pilot study of daratumumab (an mAb directed against CD38) in muscle-invasive bladder cancer (MIBC) and treatment-refractory metastatic renal cell carcinoma (mRCC).
Experimental Design:
Patients with MIBC underwent baseline transurethral resection of the bladder tumor followed by four weekly doses of daratumumab prior to cystectomy. Patients with mRCC underwent baseline and sequential biopsies after eight weekly doses. The primary endpoint was safety. The secondary endpoints were pathologic complete response rate for the MIBC cohort and objective response rate and progression-free survival for the mRCC cohort. Exploratory analyses included immune monitoring and overall survival. A Bayesian sequential monitoring design for toxicity was used for excessive toxicity.
Results:
In both the MIBC (n = 8) and mRCC (n = 8) cohorts, no toxicity events were encountered. In the MIBC cohort, one patient experienced pathologic complete response rate. In the mRCC cohort, no objective responses were reported, and the median progression-free survival was 1.5 months (95% confidence interval, 1.1–1.8 months). Immune monitoring found significant reductions in NK cells in circulation in both cohorts after treatment. In the tissue analysis, IHC found evidence of diminished CD38 presence in mRCC with treatment, whereas the baseline levels in MIBC were low.
Conclusion:
Treatment with daratumumab was safe. No signal of efficacy was detected in mRCC, and conclusions on the activity in MIBC were limited. Evidence of daratumumab targeting CD38 was detected in circulating immune cells and within the tumor microenvironment of mRCC and MIBC.
Significance:
In this prospective clinical trial of daratumumab, treatment in patients with MIBC and mRCC was safe. Limited efficacy was observed. Treatment with daratumumab resulted in CD38-expressing immune cell subsets to be targeted both in circulation and within the tumor microenvironment.
CCTA-Guided Invasive Coronary Angiography in Patients With CABG: A Multicenter, Randomized Study
Authors: Tsigkas Grigorios , Toulgaridis Fotios , Apostolos Anastasios , Kalogeropoulos Andreas , Karamasis Grigoris V. , Vasilagkos Georgios , Pappas Loukas , Toutouzas Konstantinos , Tsioufis Konstantinos , Korkonikitas Panagiotis , Tsiafoutis Ioannis , Hamilos Michalis , Ziakas Antonios , Kanakakis Ioannis , Moulias Athanasios , Zampakis Petros , Davlouros Periklis , Papanikolaou Amalia , Spyropoulou Panagiota , Chlorogiannis Dimitrios David , Chamakioti Mirsini , Spanou Eleftheria , Kartas Nikolaos , Vithoulkas Nikolaos , Sideris Antonios , Zacharoulis Achilleas , Lampropoulos Konstantinos , Georgopoulos Stamatis , Synetos Andreas , Latsios Georgios , Alexopoulos Dimitrios , Argentos Stilianos , Xenogiannis Iosif , Triantafyllou Konstantinos , Patsilinakos Sotirios , Fagkrezos Dimitrios , Mantis Christos , Pappa Aikaterini , Koutouzis Michail , Sakellaropoulou Antigoni , Kochiadakis Georgios , Kladou Eleni , Sianos Georgios , Kouparanis Antonios , Karagiannidis Efstratios , Daios Stylianos , Papoutsis Dimitrios , Sertedaki Eleni
Published: September 2024

BACKGROUND:

Coronary computed tomography angiography (CCTA) in patients with post–coronary artery bypass graft (CABG) has a high diagnostic accuracy for visualization of grafts. Invasive coronary angiography (ICA) in patients with CABG is associated with increased procedural time, contrast agent administration, radiation exposure, and complications, compared with non-CABG patients. The aim of this multicenter, randomized controlled trial was to compare the strategy of CCTA-guided ICA versus classic ICA in patients with prior CABG.

METHODS:

Patients with prior CABG were randomly assigned (1:1 ratio) to have a CCTA before ICA (CCTA-ICA, group A) or not (ICA-only, group B). The primary end point of the study was the total volume (milliliters) of the contrast agent administered.

RESULTS:

A total of 251 patients were randomized, and 225 were included in analysis; 110 in group A and 115 in group B. The total contrast volume was higher in group A (184.5 [143–255] versus 154 [102–240] mL;
P
=0.001). The contrast volume administered during the invasive procedure was lower in group A (101.5 [60–151] versus 154 [102–240];
P
<0.001). Total fluoroscopy time was decreased in group A (480 [259–873] versus 594 [360–1080] seconds;
P
=0.027), but total effective dose was increased (24.1 [17.7–32] versus 10.8 [5.6–18] mSv;
P
<0.001). The rate of contrast-induced nephropathy, periprocedural complications, and major adverse cardiac events during 3 to 5 and 30 days did not differ significantly between the 2 groups.

CONCLUSIONS:

A CCTA-directed ICA strategy for patients with CABG is associated with expedition of the invasive procedure, and less fluoroscopy time, at the cost of higher total contrast volume and effective radiation dose, compared with the classic ICA approach.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT04631809.
A new autumn-flowering Crocus (Iridaceae) from Türkiye: C. rifatozdemiri sp. nov.
Authors: ŞIK LEVENT , YAZICI CEYDA , MOLLMAN RACHEL ROSE , HARPKE DOERTE , KALELI BILGE SAADET , ÇIFTÇI ALMILA , EROL OSMAN
Published: September 2024

C. rifatozdemiri sp. nov. is a new autumn-blooming species from Crocus series Crocus described from three locations on Mount Çal in Muğla province in southwest Türkiye. The new species is notable for its large showy white flowers with sharply mucronate segment tips and contrasting bright red stigma branches. The exceptionally tall stigma is what most clearly differentiates the new species from its closest relatives, with its long branches that usually divide from above the anther tips, although other morphological features, such as tunic neck and tepal shape, as well as molecular data, support its separation from other members of series Crocus. nrETS and nrITS nuclear regions were used to infer the phylogenetic affiliation of the new species within series Crocus, resulting in a clear separation between it and closest relative C. kofudagensis, as well as other members of the series. Leaf anatomy was found to be similar to other members of series Crocus, which tend to show minimal differences between species. Finally, a full description and diagnosis, chromosome count, line illustration and figures detailing the features of this new endemic taxon, which is so far known only from one mountain in Türkiye.
A new berry-fruited Begonia (Begoniaceae) from Arunachal Pradesh, India
Authors: DAS BIKAS , SAIKIA JADUMONI , KONWAR PARTHAPRATIM , SIGA APPU , BANIK DIPANWITA
Published: September 2024

A new berry-fruited Begonia in section Platycentrum (Begoniaceae) from Arunachal Pradesh, Northeast India is described here based on morphological and molecular evidence. The new species shows close phenotypic affinities with B. silletensis and B. aborensis. A detailed description is provided along with coloured photo plates, comparison with its closely allied taxa, distribution map and provisional conservation status. The systematic position is also established herein among the closely allied taxa based on ITS2 sequences.
Catalog of the Robber Flies of India (Diptera: Asilidae)
Authors: YATOO SUHAIB FIRDOUS , WACHKOO AIJAZ AHMAD , PILLAI KAVYA G. , COHEN CHRIS M.
Published: September 2024

A catalog of the species of Asilidae occurring in modern India is provided, based primarily on an extensive review of relevant literature. We report nine subfamilies, 60 valid genera and 478 valid species present in India; 368 species (77%) of the fauna, are currently only known from India and may be endemic, while 27 more species have been removed from the Indian list. The catalog entries provide taxonomic, synonymical, nomenclatural, and geographic information for all species taxa. This work represents just the first step in what must be a thorough and systematic review of the Indian Asilidae fauna.
Chironomidae (Diptera: Insecta) of Alaska, USA, with descriptions of new species and a checklist
Authors: NAMAYANDEH ARMIN , HUDSON PATRICK L. , BOGAN DANIEL L. , HUDSON JOHN P.
Published: September 2024

The current study results from the collection of Chironomidae, which began in 1994 and continued until the present time in six biogeographical regions of Alaska, USA. We established that 427 species are currently reported from Alaska, adding 154 new faunistic records and six new species. In this study, we described Chaetocladius (Chaetocladius) kimfrangosi sp. nov., Chaetocladius (Chaetocladius) mendenhallensis sp. nov., Chaetocladius (Chaetocladius) tonitrus sp. nov., Corynoneura palus sp. nov., Stilocladius keithsomersi sp. nov., and Paratanytarsus giminilacus sp. nov.. Additionally, we describe the larva of a pupa Roback (1971) thought likely to belong to Krenopelopia narda Roback, 1971, the female of Cricotopus (Paratrichocladius) scaturigineus (Makarchenko & Makarchenko, 2014), and the female and pupa of Heleniella parva Sæther, 1985. For the first time, we provided a checklist of Chironomidae with distributional records from Alaska.
Comparing MJO Intensity over the Tropical Western Pacific during Mega and Equatorial La Niña Winters
Authors: Cao Can , Wu Zhiwei
Published: September 2024

This study investigated variations in the Madden–Julian oscillation (MJO) behavior between two types of La Niña winters: mega and equatorial La Niñas. Results of this work show that in contrast to mega conditions, accompanied by more abundant intraseasonal column-integrated moisture anomalies over the planetary boundary layer, intensities of intraseasonal outgoing longwave radiation anomalies are stronger over the tropical western Pacific (WP) at MJO phases 5–6 under equatorial conditions. The occurrence of the moisture anomaly change averaged over the tropical WP is supported by a distinct moisture tendency difference. Moisture budget and multiscale interaction diagnoses underscore the pivotal effect of an area-averaged vertical gradient change in low-frequency background moisture in driving such tendency change. Considering notable MJO convection variations, the teleconnections associated with MJO phases 5–6 over East Asia (EA) were also explored, including warmer surface air temperature anomalies and stronger positive geopotential height anomalies at 200 hPa on the intraseasonal time scale under equatorial conditions. Results from a linear baroclinic model demonstrate that such teleconnection changes could be effectively explained by the linear response to the MJO’s diabatic heating anomaly. Roles of mean state and MJO itself variations in the linear response change are also discussed. These findings provide novel insights into MJO activity and offer potential improvements for subseasonal forecasting in EA.

Significance Statement

The relationship between El Niño–Southern Oscillation (ENSO) and MJO has been extensively explored recently. However, variations in the MJO behavior and its climate effects under mega and equatorial La Niña winters have not been thoroughly investigated. In this work, we utilized reanalysis datasets and an idealized linear baroclinic model to address these questions. We observed more robust and abundant intraseasonal convection activity and planetary boundary layer–integrated moisture anomaly averaged over the tropical WP at MJO phases 5–6 under equatorial conditions than mega conditions, which is closely linked with the vertical gradient change in low-frequency background moisture. Additionally, MJO-related teleconnections also exhibit some changes. This work may provide a new perspective on understanding the relationship between the MJO and ENSO and offer potential improvements for the subseasonal forecast.
The Engagement and Disengagement of Heterogeneous Stakeholders: A Relational Practice Perspective on Strategy Development
Authors: Bader Verena , Schneider Anna-Lisa , Kaiser Stephan , Loscher Georg
Published: September 2024

In this article, we underscore the importance of stakeholder relationships for research on stakeholder engagement. We do so by integrating a practice-based understanding with the relational view. Based on a revealing case study of a civic engagement process in a large German city, we develop a conceptual framework that explains how relational practices shape stakeholder engagement. We identify three relational practices (i.e., connecting, facilitating, and containing) and their associated outcomes (i.e., implication, solidarization, and distinction), as well as effects on stakeholder heterogeneity. Our findings contribute to the relational view on stakeholder engagement by providing insights into practices that shape relationships between heterogeneous stakeholders, explaining how these relational practices influence stakeholder heterogeneity, and identifying unintended impacts of stakeholder engagement.
Social Participation Restrictions and Explanatory Factors in Adults with Oculopharyngeal Muscular Dystrophy
Authors: Muslemani Samar , Brisson Jean-Denis , Côté Isabelle , Lessard Isabelle , Côté Claudia , Brais Bernard , Gagnon Cynthia
Published: September 2024

Background. Limited knowledge is available regarding the impact of oculopharyngeal muscular dystrophy (OPMD) impairments on participation in daily and social activities, which currently hinders occupational therapy practice in this population. Purpose. To describe social participation and explore influencing factors in individuals with OPMD. Methods. Thirty-four individuals were assessed with outcome measures of social participation restrictions, mobility, dysphagia, and fatigue. Spearman correlations and stepwise multiple regression analyses were used. Findings. Results show a negative impact of OPMD on the social participation level, which was more important in participants aged over 60 years. Walking speed was found to be the main factor influencing participation levels for daily and social activities, with faster walking associated with higher participation. Conclusions. This study emphasizes the impact of OPMD impairments and limitations on social participation level. While dysphagia is obviously an important impairment to consider, interventions for mobility limitations should also be considered during clinical follow-up.
Minimum zone fitting and error evaluation for arc correction type convex contour of bearing roller
Authors: Man Ruidong , Ma Zhenyu , Lei Xianqing , Tu Xianping , Wang Xiaoyi , Yang Chuanmeng
Published: September 2024

The minimum zone fitting and error evaluation for the arc-modified convex contour of a bearing roller have important applications for consistency detection and quantificational research of the elastohydrodynamic lubrication of a bearing roller. Based on the definition of the shape error and the geometric characteristics of the arc corrected roller convexity line of the bearing, a new fitting and error evaluation method for the total convexity contour of a bearing roller is presented. First, the reference cutoff points of the arc segment and straight line are determined based on the curvature difference of each measurement point. Then, the measuring points on both sides of the two reference cutoff points are selected as auxiliary cutoff points for arc fitting. The fitting error is obtained based on the minimum area method. Finally, a series of tangent equations are obtained based on the tangent principle between a line and two arcs, and the straightness error is determined by calculating the distances between the measuring points and the tangents. The example results show that an arc-modified convex contour can be fitted, and its global error can be evaluated effectively and precisely using the presented method. This study also provides a new idea for the minimum zone fitting of multi-segment curves along a plane.
Optimization of aero-engine condition monitoring by autoregressive model analysis based on wireless communication
Authors: Xin Mai , Ye Zhifeng , Liu Xing , Pan Xiong
Published: September 2024

The high value of aero-engines makes it necessary to extend their life in terms of econ-omy of use. Health management is an important basis for this work. Background: The vibration signal is an important representation of the working state of an aero-engine. The current usual method is based on wired communication with simple waveform presentation. The many incon-veniences of this method have seriously affected the further development of this work. Methods: This research team acquires engine vibration signals in real time through a designed wireless signal sensor, and then analyzes and visualizes the signals in depth. Results: Through this method, it can visually and effectively demonstrate signal characteristics for engineers, effectively identify fault signals, and monitor engine operating conditions in real time. Conclusions: The method enables the optimization of aero-engine work-state monitoring.