bluuebunny/crossref_metadata_2025 huggingface dataset:
At the crossroads: strigolactones mediate changes in cytokinin synthesis and signalling in response to nitrogen limitation
Authors: Sigalas Petros P. , Bennett Tom , Buchner Peter , Thomas Stephen G. , Jamois Frank , Arkoun Mustapha , Yvin Jean‐Claude , Bennett Malcolm J. , Hawkesford Malcolm J.
Published: August 2024

Strigolactones (SLs) are key regulators of shoot growth and responses to environmental stimuli. Numerous studies have indicated that nitrogen (N) limitation induces SL biosynthesis, suggesting that SLs may play a pivotal role in coordinating systemic responses to N availability, but this idea has not been clearly demonstrated. Here, we generated triple knockout mutants in the SL synthesis gene TaDWARF17 (TaD17) in bread wheat and investigated their phenotypic and transcriptional responses under N limitation, aiming to elucidate the role of SLs in the adaptation to N limitation. Tad17 mutants display typical SL mutant phenotypes, and fail to adapt their shoot growth appropriately to N. Despite exhibiting an increased tillering phenotype, Tad17 mutants continued to respond to N limitation by reducing tiller number, suggesting that SLs are not the sole regulators of tillering in response to N availability. RNA‐seq analysis of basal nodes revealed that the loss of D17 significantly altered the transcriptional response of N‐responsive genes, including changes in the expression profiles of key N response master regulators. Crucially, our findings suggest that SLs are required for the transcriptional downregulation of cytokinin (CK) synthesis and signalling in response to N limitation. Collectively, our results suggest that SLs are essential for the appropriate morphological and transcriptional adaptation to N limitation in wheat, and that the repressive effect of SLs on shoot growth is partly mediated by their repression of CK synthesis.
Regional inequalities in the age of nearshoring
Authors: Capello Roberta , Dellisanti Roberto
Published: August 2024

While the literature is rich in anecdotal cases of firms going through nearshoring strategies, understood as the relocation of production inputs in a geographically closer area, a study on the macroeconomic effects of nearshoring at regional level, in terms of both growth and regional inequalities, is still missing. Instead, understanding the potential regional variations in the outcomes of nearshoring practices is crucial for policymakers and stakeholders aiming to strike a balance between the imperative of strategic autonomy and the need to address existing regional disparities. The paper picks up such a challenge and, once nearshoring has been defined at the macroeconomic level as a process according to which the EU relative to extra‐EU inputs ratio increases, compared with a reference period in the past, it analyses regional inequality effects of such a phenomenon in Europe. The results show that nearshoring turns out to be notably diverse and contingent upon the efficiency gains the target regions offer. In some cases, it produces potential adverse consequences, going against the already complex process of decreasing regional disparities.
Biological impact of manual blood exchange in malignant Bordetella pertussis infection in infants
Authors: Cousin Vladimir L. , Caula Caroline , Tissières Pierre
Published: August 2024

Background and Objectives

Manual blood exchange (MBE) is a leukoreduction therapy for hyperleukocytosis in Bordetella spp. infection. We describe the impact of BE on clinical and biological parameters in critically ill children with malignant pertussis.

Materials and Methods

This is a monocentric retrospective review of patients with malignant pertussis infection treated with MBE. It describes the evolution of haemodynamic, ventilatory, haematologic and metabolic characteristics before and after MBE.

Results

Between January 2006 and December 2021, nine patients (median age 43 days, range: 13–80 days) had 16 MBE for malignant pertussis. All patients were mechanically ventilated, and 7/9 patients developed pulmonary hypertension during their paediatric intensive care unit (PICU) stay. Overall, 3/9 patients survived, and the mean PICU length of stay was 8.5 days (range: 1–52 days). We found a significant reduction of the leukocyte count (pre‐MBE: 61.8 G/L [interquartile range (IQR): 55.8–74.8] vs. post‐MBE: 19.4 G/L [IQR: 17.7–24.1]; p ≤ 0.001) and significant oxygenation improvement (pre‐MBE SpO2/FiO2: 190 [IQR: 106–200] vs. post‐MBE SpO2/FiO2: 242 [IQR: 149–250]; p = 0.03). The main side effects were a significant reduction of thrombocytes (pre‐MBE: 411 G/L [IQR: 166.5–563.5] vs. post‐MBE: 66 G/L [IQR: 46–82.5]; p = <0.001) and of ionized calcium (iCa) (pre‐MBE iCa: 1.3 [IQR: 1.22–1.37] vs. post‐MBE iCa: 1.25 [IQR: 1.85–2.24]; p = 0.03).

Conclusion

MBE efficiently reduces leukocytes and improves oxygenation in severe Bordetella pertussis infection in infants. Careful monitoring of calcium and thrombocytes seems mandatory.
Chemically Engineered Devices for Skin Analysis: A Comprehensive Mini-Review
Authors: Mohd Arif Shahkila , Md Lazim Nurul Asmak
Published: August 2024

Among all organs in humans, the skin is considered the largest organ and is covered on the surface of the human body. It is continuously exposed to and affected by many harsh conditions, like natural, chemical, and anthropogenic nanomaterials, from external and internal contributions. This phenomenon may cause irreversible health effects, from skin corrosion to cancer. Thus, there is an increasing demand for minimal monitoring of everything that may jeopardize skin conditions, especially human facials. These include noninvasive in situ analysis of body fluids that may contribute to unhealthy skin in the human body. This adaptation urges the researchers to develop many types of electrochemically active materials and wearable biosensors. This attempt with mechanically soft and flexible materials enables them to suit the geometric nonlinearity of the human skin. For each device's design, its purpose is different. Therefore, this mini-review will summarize the developments of skin analyzers with chemical engineering design. In short, this review will cover five type of skin conditions with different analyzers: (i) normal skin conditions; (ii) sweat skin analysis; (iii) skin hydration; (iv) skin wounds; and (v) the secretion of organic chemicals through the skin. For each criterion, the reaction of each analyte to the sensor performance was also discussed. Special attention is also included regarding the safety, usage, and reusability of the devices. In certain cases, there is also data security, which the authors may consider elaborate. From here, the authors hope that this review can benefit those interested in developing future commercialized sensors for skin analysis.
Arithmetic progressions and holomorphic phase retrieval
Authors: Liehr Lukas
Published: August 2024

We study the determination of a holomorphic function from its absolute value. Given a parameter , we derive the following characterization of uniqueness in terms of rigidity of a set : if is a vector space of entire functions containing all exponentials , then every is uniquely determined up to a unimodular phase factor by if and only if is not contained in an arithmetic progression . Leveraging this insight, we establish a series of consequences for Gabor phase retrieval and Pauli‐type uniqueness problems. For instance, is a uniqueness set for the Gabor phase retrieval problem in , provided that is a suitable perturbation of the integers.
Early detection of highly transmissible viral variants using phylogenomics
Authors: May Michael R. , Rannala Bruce
Published: August 2024

As demonstrated by the SARS-CoV-2 pandemic, the emergence of novel viral strains with increased transmission rates poses a serious threat to global health. Statistical models of genome sequence evolution may provide a critical tool for early detection of these strains. Using a novel stochastic model that links transmission rates to the entire viral genome sequence, we study the utility of phylogenetic methods that use a phylogenetic tree relating viral samples versus count-based methods that use case counts of variants over time exclusively to detect increased transmission rates and identify candidate causative mutations. We find that phylogenies in particular can detect novel transmission-enhancing variants very soon after their origin and may facilitate the development of early detection systems for outbreak surveillance.
Remodeling p38 signaling in muscle controls locomotor activity via IL-15
Authors: Folgueira Cintia , Herrera-Melle Leticia , López Juan Antonio , Galvan-Alvarez Victor , Martin-Rincon Marcos , Cuartero María Isabel , García-Culebras Alicia , Dumesic Phillip A. , Rodríguez Elena , Leiva-Vega Luis , León Marta , Porteiro Begoña , Iglesias Cristina , Torres Jorge L. , Hernández-Cosido Lourdes , Bonacasa Clara , Marcos Miguel , Moro María Ángeles , Vázquez Jesús , Calbet Jose A. L. , Spiegelman Bruce M. , Mora Alfonso , Sabio Guadalupe
Published: August 2024

Skeletal muscle has gained recognition as an endocrine organ releasing myokines upon contraction during physical exercise. These myokines exert both local and pleiotropic health benefits, underscoring the crucial role of muscle function in countering obesity and contributing to the overall positive effects of exercise on health. Here, we found that exercise activates muscle p38γ, increasing locomotor activity through the secretion of interleukin-15 (IL-15). IL-15 signals in the motor cortex, stimulating locomotor activity. This activation of muscle p38γ, leading to an increase locomotor activity, plays a crucial role in reducing the risk of diabetes and liver steatosis, unveiling a vital muscle-brain communication pathway with profound clinical implications. The correlation between p38γ activation in human muscle during acute exercise and increased blood IL-15 levels highlights the potential therapeutic relevance of this pathway in treating obesity and metabolic diseases. These findings provide valuable insights into the molecular basis of exercise-induced myokine responses promoting physical activity.
Structure and mechanism of the osmoregulated choline transporter BetT
Authors: Yang Tianjiao , Nian Yuwei , Lin Huajian , Li Jing , Lin Xiang , Li Tianming , Wang Ruiying , Wang Longfei , Beattie Gwyn A. , Zhang Jinru , Fan Minrui
Published: August 2024

The choline–glycine betaine pathway plays an important role in bacterial survival in hyperosmotic environments. Osmotic activation of the choline transporter BetT promotes the uptake of external choline for synthesizing the osmoprotective glycine betaine. Here, we report the cryo–electron microscopy structures of
Pseudomonas syringae
BetT in the apo and choline-bound states. Our structure shows that BetT forms a domain-swapped trimer with the C-terminal domain (CTD) of one protomer interacting with the transmembrane domain (TMD) of a neighboring protomer. The substrate choline is bound within a tryptophan prism at the central part of TMD. Together with functional characterization, our results suggest that in
Pseudomonas
species, including the plant pathogen
P. syringae
and the human pathogen
Pseudomonas aeruginosa
, BetT is locked at a low-activity state through CTD-mediated autoinhibition in the absence of osmotic stress, and its hyperosmotic activation involves the release of this autoinhibition.
Supplemental Material: Newly discovered Early Cretaceous Au mineralization overprinting Late Jurassic Pb-Zn-Ag mineralization in the Qin-Hang metallogenic belt (South China)
Authors: Shen Hongjie , Zhang Yu , et al.
Published: August 2024

Table S1: Descriptions of representative sulfide samples at Kangjiawan. Table S2: Analytical methods. Table S3: Major- and minor-element data obtained by EPMA for the different types of pyrite from Kangjiawan. Table S4: Trace-element data obtained by LA-ICP-MS for the different types of pyrite from Kangjiawan. Table S5: LA-ICP-MS U-Pb isotope data for apatite from Kangjiawan. Table S6: 40Ar/39Ar incremental heating data of fuchsite from Kangjiawan. Table S7: LA-ICP-MS U-Pb isotope data (spot analyses) for calcite from Kangjiawan. Table S8: LA-ICP-MS U-Pb isotope data (line scans) for calcite from Kangjiawan. Table S9: δ34SVCDT values of sulfides from Kangjiawan. Table S10: Lead isotope data of pyrite and galena from Kangjiawan.
Assessing the effect of concerns about contraceptive-induced fertility impairment on hormonal contraceptive use by parity and residence: evidence from PMA Ethiopia 2020 cross-sectional survey
Authors: Zimmerman Linnea A , Karp Celia , Shiferaw Solomon , Seme Assefa , Bell Suzanne O
Published: August 2024

Objectives

This study aims to describe patterns of beliefs about contraceptive-induced infertility and assess their relationship with current contraceptive use, including whether these relationships vary by parity and residence.

Design

We use data from Performance Monitoring for Action Ethiopia, a nationally representative, cross-sectional survey of 7491 women, aged 15–49, to assess agreement with the statement ‘If I use family planning, I may have trouble getting pregnant next time I want to.’ We used multilevel hierarchical models to identify the association between agreement and use of a hormonal method of contraception among 3882 sexually active, fecund women who wish to prevent pregnancy. We include interaction terms for parity and residence.

Results

4 in 10 women disagreed (42.3%) and 2 in 10 strongly disagreed (20.7%) with the statement. Relative to women who strongly disagreed, women who disagreed and women who agreed had significantly lower odds of using a hormonal method of contraception (adjusted OR (aOR) 0.65, 95% CI 0.44 to 0.97 and 0.46, 95% CI 0.46, 95% CI 0.30 to 0.70). The effect of agreeing with the statement was strongest among high parity women (aOR 0.54, 95% CI 0.30 to 0.95). Greater agreement with the statement at the community-level use was associated with a reduction in the odds of using hormonal contraception but only among rural women.

Conclusions

Efforts to address concerns around contraceptive-induced fertility impairment through the provision of comprehensive counselling and through community education or mass media campaigns are necessary, particularly among high-parity women and in rural communities. Interventions should acknowledge the possibility of delayed return to fertility for specific methods and attempt to address the root causes of concerns.
Prevalence and associated factors of suspected occupational skin diseases among restaurant workers in peninsular Malaysia: secondary data analysis of Registry for Occupational Disease Screening (RODS)
Authors: Ahmad Fuad Mohd Hazim , Samsudin Ely Zarina , Yasin Siti Munira , Ismail Nurhuda , Mohamad Mariam , Muzaini Kamarulzaman , Anuar Mohd Ridzuan , Govindasamy Kesavan , Ismail Ismassabah , Elias Anza , Taib Khairul Mizan , Mohamed Anis Syamimi , Azhari Noor Ahmad Faiz , Abdullah Hair Ahmad Fitri
Published: August 2024

Objectives

Occupational skin diseases (OSDs) pose significant risks to the health and well-being of restaurant workers. However, there is presently limited evidence on the burden and determinants of OSDs among this occupational group. This research aims to estimate the prevalence and associated factors of suspected OSDs among restaurant workers in Peninsular Malaysia.

Design

A secondary data analysis of the 2023 Registry of Occupational Disease Screening (RODS) was performed. The RODS survey tool, which included the Nordic Occupational Skin Questionnaire, a symptoms checklist and items on work-relatedness, was used to screen for OSDs. Logistic regression analyses were performed to identify associated factors.

Setting and participants

Restaurant workers (n=300) registered in RODS from February 2023 to April 2023, aged 18 years and above and working in restaurants across Selangor, Melaka and Pahang for more than 1 year, were included in the study, whereas workers who had pre-existing skin diseases were excluded.

Results

The prevalence of suspected OSDs among study participants was 12.3%. Higher odds of suspected OSDs among study participants were observed among those exposed to wet work (adjusted OR (AOR) 22.74, 95% CI 9.63 to 53.68) and moderate to high job stress levels (AOR 4.33, 95% CI 1.80 to 10.43).

Conclusions

These findings suggest that OSDs are a significant occupational health problem among restaurant workers. Interventions targeting job content and wet work may be vital in reducing OSDs among this group of workers.
Effects of a carbohydrate-reduced high-protein diet delivered with meal kits to Danish people with type 2 diabetes: protocol for a 12-month randomised controlled trial
Authors: Kopp Luise H P , Søgaard-Hansen Christina M , Zachhau Karen M , Bastkjær Rasmus M , Andersen Barbara V , Budtz-Jørgensen Esben , Byrne Derek V , Chaaban Nora , Holst Jens J , Klindt Trine B , Magkos Faidon , Ozenne Brice , Samkani Amirsalar , Skytte Mads J , Madsbad Sten , Krarup Thure , Thomsen Mads N
Published: August 2024

Introduction

The cornerstone in the management of type 2 diabetes (T2D) is lifestyle modification including a healthy diet, typically one in which carbohydrate provides 45%–60% of total energy intake (E%). Nevertheless, systematic reviews and meta-analyses of trials with low carbohydrate diets (which are increased in protein and/or fat) for T2D have found improved glycaemic control in the first months relative to comparator diets with higher carbohydrate content. Studies lasting ≥1 year are inconclusive, which could be due to decreased long-term dietary adherence. We hypothesise that glucometabolic benefits can be achieved following 12 months of carbohydrate-restricted dieting, by maximising dietary adherence through delivery of meal kits, containing fresh, high-quality ingredients for breakfast, dinner and snacks, combined with nutrition education and counselling.

Methods and analysis

This protocol describes a 12-month investigator-initiated randomised controlled, open-label, superiority trial with two parallel groups that will examine the effect of a carbohydrate-reduced high-protein (CRHP) diet compared with a conventional diabetes (CD) diet on glucometabolic control (change in glycated haemoglobin being the primary outcome) in 100 individuals with T2D and body mass index (BMI) >25 kg/m
2
. Participants will be randomised 1:1 to receive either the CRHP or the CD diet (comprised 30/50 E% from carbohydrate, 30/17 E% from protein and 40/33 E% from fat, respectively) for 12 months delivered as meal kits, containing foods covering more than two-thirds of the participants’ estimated daily energy requirements for weight maintenance. Adherence to the allocated diets will be reinforced by monthly sessions of nutrition education and counselling from registered clinical dietitians.

Ethics and dissemination

The trial has been approved by the National Committee on Health Research Ethics of the Capital Region of Denmark. The trial will be conducted in accordance with the Declaration of Helsinki. Results will be submitted for publication in international peer-reviewed scientific journals.

Trial registration number

NCT05330247
.

Protocol version

The trial protocol was approved on 9 March 2022 (study number: H-21057605). The latest version of the protocol, described in this manuscript, was approved on 23 June 2023.
Age-related differences in diffusion-weighted imaging lesion volume and reversal in patients with successful recanalization after mechanical thrombectomy
Authors: Takaishi Satoshi , Ueda Toshihiro , Usuki Noriko , Tatsuno Kentaro , Yoshie Tomohide , Yamano Yoshihisa
Published: August 2024

Background

With the advancement of mechanical thrombectomy (MT), post-treatment diffusion-weighted imaging (DWI) lesion reversal (DWIR) has been reported. This study aimed to compare the volumes of DWI lesions and the frequencies of DWIR between younger and elderly patients who underwent successful recanalization with MT.

Methods

The study retrospectively analyzed 177 consecutive patients who underwent successful recanalization with MT for anterior large vessel occlusion (LVO) at our hospital between April 2011 and September 2022. Patients were categorized into two age groups: <70 years and ≥70 years. MRI was performed before treatment and 24 hours after treatment. The DWI lesion volumes and DWIR frequencies were compared between the two groups.

Results

The median age of the patients was 78 years and 19.8% were in the <70 years group. No significant differences were found between the groups in terms of occluded vessel sites and recanalization time. The baseline DWI lesion was significantly larger in the <70 years group (16.0 mL vs 4.0 mL, P<0.001). The frequency of DWIR did not significantly differ between the groups (65.7% vs 55.6%). DWI lesion volume significantly decreased after treatment in the <70 years group but showed no significant change in the ≥70 years group.

Conclusions

In patients who underwent successful recanalization after MT for anterior LVO, baseline DWI lesions were significantly larger in younger patients compared with elderly patients. Although more than half of the patients in both age groups experienced DWIR, a significant reduction in DWI lesion volume was only observed in younger patients.
Prompt neutron emission calculations for the photon induced reactions of 238U and 232Th in the giant dipole resonance energy region
Authors: Tudora Anabella , Filipescu Dan Mihai , Gheorghe Ioana
Published: August 2024

Prompt emission calculations for the photon induced fission of 238U and 232Th in the GDR energy region were performed by using (a) a systematic of input parameters for the most probable fragmentation approach (obtained on the basis of only spontaneous and neutron induced fission of actinides) and (b) photo-fission cross section ratios (expressing the fission probabilities at incident energies where multiple fission chances are involved) provided by nuclear reaction calculations performed with the EMPIRE code. The prompt neutron emission results describe well the experimental data recently measured at the laser Compton-scattering γ-ray source of the NewSUBARU facility, validating the use of this input parameter systematic for photon induced fission, too. The modelings and procedures described in this paper can constitute an useful tool for the prediction of prompt neutron emission data in photon induced reactions without any experimental information.
Electroweak strings in the standard model
Authors: Zou Liping , Zhang Pengming , Cho Y. M.
Published: August 2024

We argue that the existence of the electroweak monopole predicts the existence of the electroweak string in the standard model made of monopole–antimonopole pair separated infinitely apart, which carry the quantized magnetic flux $$4 \pi n/e$$

4
π
n
/
e

. We show how to construct such quantized magnetic flux string solution. Our result strongly indicates that genuine fundamental electromagnetic string could exist in nature which could actually be detected. We discuss the physical implications of our result in cosmology.
Spectral phase pulse shaping reduces ground state depletion in high-order harmonic generation
Authors: Aygun J. , Buitrago C. G. , Ciappina M. F. , Harris A. L.
Published: August 2024

High-order harmonic generation (HHG) has become an indispensable process for generating attosecond pulse trains and single attosecond pulses used in the observation of nuclear and electronic motion. As such, improved control of the HHG process is desirable, and one such possibility for this control is through the use of structured laser pulses. We present numerical results from solving the one-dimensional time-dependent Schrödinger equation for HHG from hydrogen using Airy and Gaussian pulses that differ only in their spectral phase. Airy pulses have identical power spectra to Gaussian pulses, but different spectral phases and temporal envelopes. We show that the use of Airy pulses results in less ground state depletion compared to the Gaussian pulse, while maintaining harmonic yield and cutoff. Our results demonstrate that Airy pulses with higher intensity can produce similar HHG spectra to lower intensity Gaussian pulses without depleting the ground state. The different temporal envelopes of the Gaussian and Airy pulses lead to changes in the dynamics of the HHG process, altering the time-dependence of the ground state population and the emission times of the high harmonics.

Graphical abstract
Causality and quasi-normal modes in the GREFT
Authors: Melville Scott
Published: August 2024

The General Relativity Effective Field Theory (GREFT) introduces higher-derivative interactions to parameterise the gravitational effects of massive degrees of freedom which are too heavy to be probed directly. The coefficients of these interactions have recently been constrained using causality: both from the analytic structure of 4-point graviton scattering and the time delay of gravitational waves on a black hole background. In this work, causality is used to constrain the quasi-normal mode spectrum of GREFT black holes. Demanding that quasi-normal mode perturbations decay faster in the GREFT than in General Relativity—a new kind of causality condition which stems from the analytic structure of 2-point functions on a black hole background—leads to further constraints on the GREFT coefficients. The causality constraints and compact expressions for the GREFT quasi-normal mode frequencies presented here will inform future parameterised gravitational waveforms, and the observational prospects for gravitational wave observatories are briefly discussed.
Environmental and Historical Determinants of African Horse Sickness: Insights from Predictive Modeling
Authors: Kim KwangHyok , Xu TianGang , Kannan Villalan Arivizhivendhan , Chi TianYing , Yu XiaoJing , Jin MyongIl , Wu RenNa , Ni GuanYing , Sui ShiFeng , Wang ZhiLiang , Wang XiaoLong
Published: August 2024

African horse sickness (AHS) is a viral disease transmitted by arthropods that impacts Equidae, specifically horses and related species. Recognized as a notifiable disease by the World Organisation for Animal Health (WOAH), AHS is associated with a high mortality rate of 80%–90% in susceptible hosts and exhibits rapid transmission dynamics. Historical records document numerous instances of mass horse deaths attributed to AHS, with recent occurrences in Thailand and Malaysia in 2020 causing heightened concerns within the local horse industry. The lack of a comprehensive global perspective on the distribution and transmission of AHS poses challenges in comprehending and implementing effective prevention and control strategies. This study marks a pioneering effort in analyzing the global epidemiological patterns of AHS across different regions. By employing predictive modeling with a comprehensive set of environmental variables, we uncovered overarching global patterns in AHS dynamics, a first in this field. Our analysis revealed significant regional differences influenced by specific climatic conditions, highlighting the disease’s complexity. The study also identifies new high‐risk areas for AHS, underscoring the necessity for regionally tailored disease management strategies. Despite some limitations, such as the exclusion of wild equine data, this research offers critical insights for global AHS intervention and prevention, setting a path for future research incorporating broader datasets and socioeconomic factors.
Atmosphere at Briefing Sessions and Its Influence on Local Residents’ Intention to Participate in Discussion
Authors: Okuyama Tomotaka , Aoki Toshiaki
Published: August 2024

Although it is widely recognized that atmosphere influences people’s decision‐making process, few studied have examined the effect of atmosphere in the context of consensus building concerning the construction of controversial infrastructures. At local residents’ briefing sessions, the negative words used by certain members of the strong opposition can often create a negative atmosphere, leading to unpleasant arguments. Therefore, in this study, a vignette experiment was conducted to examine the influence of the atmosphere at briefing sessions on local residents’ intention to participate in discussion. The results showed that local residents reported greater intention to participate in discussion in a positive atmosphere compared to a negative atmosphere. As for the cognitive process, however, while in the positive atmosphere only a single factor (i.e., interest) affected local residents’ intention, in the negative atmosphere multifactors (e.g., procedural justice, disbenefit, and mental burden) affected the intention. These findings suggest the importance of choosing an appropriate strategy to increase resident’s intention to participate in discussion depending on the atmosphere (positive or negative). The psychological mechanism of the influence of atmosphere and effective strategies that project implementers should take when the atmosphere becomes negative at a briefing session are discussed.
The Gust Factor Models Involving Wind Speed and Temperature Profiles for Wind Gust Estimation
Authors: Hu Haichuan , Qian Chuanhai , Gao Shibo
Published: August 2024

This study analyzed the deviation of the gust factor (GF) method in gust estimation and the differences in the vertical distribution of upper‐level wind speed and temperature when varying deviations occurred using observed data from 11 stations in central‐eastern China from January 2017 to December 2020. A unified upper‐level gust impact model was developed through multiple regression (GF‐L) and machine learning (GF‐M) methods based on data from these stations to improve gust estimation accuracy. The effectiveness of the GF, GF‐L, and GF‐M methods was compared using data from January 2021 to October 2022. Results showed that integrating the upper‐level gust impact model into the GF method reduced underestimation and improved accuracy, with the GF‐M method showing the most significant improvement. The GF‐L method reduced the root mean square error by 5.1% on average compared to the GF method, while the GF‐M method achieved a 9.2% reduction. The study confirmed the applicability of the unified upper‐level gust impact model across different stations, with the GF‐M method demonstrating better results.
Supplementary Figure 6 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

Exogenous TRPM4 expression sensitizes TRPM4 negative and acetalax-resistant MDAMB231 and MDAMB436 cells to acetalax.
Supplementary Figure 5 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

TRPM4 RNA expression and categories of gene sets enriched in response to Acetalax treatment.
Supplementary Figure 4 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

Scatter plot of Acetalax activity versus TRPM4 transcript expression.
Supplementary Figure 3 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

Mitochondrial morphological changes caused by Acetalax in BT549.
Supplementary Figure 1 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

Bisacodyl structure, effect on TNBC cell lines and similarity to Acetalax.
Figure 5 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

TRPM4 targeting and proteasomal degradation of TRPM4 by Acetalax and bisacodyl. A, Western blot of TRPM4 protein levels in MDA-MB468 following Acetalax treatment. B, Western blot of TRPM4 protein levels in MDA-MB468 following Acetalax and MG132 proteasome inhibitor treatment. C, Western blot of TRPM4 protein levels in MDA-MB468 following bisacodyl treatment. D, Western blot of TRPM4 protein levels in MDA-MB468 following bisacodyl and MG132 proteasome inhibitor treatment. The presence or absence of Acetalax or bisacodyl and MG132 is indicated in each experiment by + and/or − above each column. Cells were treated with Acetalax for 4 hours at 10 μmol/L and bisacodyl at 30 μmol/L. Cells were treated with MG132 for 4 hours at 20 μmol/L.
Figure 2 from Acetalax (Oxyphenisatin Acetate, NSC 59687) and Bisacodyl Cause Oncosis in Triple-Negative Breast Cancer Cell Lines by Poisoning the Ion Exchange Membrane Protein TRPM4
Authors: Mizunuma Makito , Redon Christophe E. , Saha Liton Kumar , Tran Andy D. , Dhall Anjali , Sebastian Robin , Taniyama Daiki , Kruhlak Michael J. , Reinhold William C. , Takebe Naoko , Pommier Yves
Published: August 2024

Morphologic changes caused by Acetalax in TNBC cell lines with differential sensitivity. A, Representative microscopy images of cell lines treated with Acetalax (10 μmol/L for 30 minutes) and stained in blue with DAPI (binds DNA) and green with phalloidin (stains actin). Control, without Acetalax treatment. Scale bars, 50 μm. (s), most Acetalax-sensitive cell lines; (r), most Acetalax-resistant cell lines (Fig. 1B). B, Top, Violin plots for the quantitation of Acetalax-induced cell size increase at 5 and 30 minutes. The numbers represent the number of cells analyzed. The lines indicate medians. Each dot is a cell. MDA-MB468, BT549, and Hs578T have significant changes in cell size. Bottom, Violin plots for the quantitation of Acetalax-induced nuclear size increase at 5 and 30 minutes. Each dot is a nucleus. The numbers represent the number of nuclei analyzed. Nuclear size increase between the control and Acetalax-treated cells significantly for MDA-MB468, BT549, and Hs578T. C, Microscopy of membrane blebbing caused by Acetalax (10 μmol/L for 30 minutes). Control, untreated cells; red arrows, cell membrane blebs. The images are chosen to fill the frames for improved visibility without normalization by scale. Scale bars, 50 μm. D, Quantitation of membrane blebbing in multiple cells as shown in C. In the most sensitive (s) cell lines, MDA-MB468, BT549, and Hs578T, Acetalax treatment significantly increased the frequency of bleb cells. Statistical significance: *, P < 0.05; **, P < 0.01; ***, P < 0.005; ****, P < 0.001; *****, P < 0.0005; ******, P < 0.0001 (using the Mann–Whitney U test, calculated in PRISM 9.0).
Table S5 from Clinical Efficacy of the HIV Protease Inhibitor Indinavir in Combination with Chemotherapy for Advanced Classic Kaposi Sarcoma Treatment: A Single-Arm, Phase II Trial in the Elderly
Authors: Sgadari Cecilia , Scoppio Biancamaria , Picconi Orietta , Tripiciano Antonella , Gaiani Francesca Maria , Francavilla Vittorio , Arancio Angela , Campagna Massimo , Palladino Clelia , Moretti Sonia , Monini Paolo , Brambilla Lucia , Ensoli Barbara
Published: August 2024

Supplementary Table 5 summarizes the representativeness of study participants
Table S4 from Clinical Efficacy of the HIV Protease Inhibitor Indinavir in Combination with Chemotherapy for Advanced Classic Kaposi Sarcoma Treatment: A Single-Arm, Phase II Trial in the Elderly
Authors: Sgadari Cecilia , Scoppio Biancamaria , Picconi Orietta , Tripiciano Antonella , Gaiani Francesca Maria , Francavilla Vittorio , Arancio Angela , Campagna Massimo , Palladino Clelia , Moretti Sonia , Monini Paolo , Brambilla Lucia , Ensoli Barbara
Published: August 2024

Supplementary Table 4 shows the treatment-related laboratory AE by SOC, preferred terms and study phases.
Table S3 from Clinical Efficacy of the HIV Protease Inhibitor Indinavir in Combination with Chemotherapy for Advanced Classic Kaposi Sarcoma Treatment: A Single-Arm, Phase II Trial in the Elderly
Authors: Sgadari Cecilia , Scoppio Biancamaria , Picconi Orietta , Tripiciano Antonella , Gaiani Francesca Maria , Francavilla Vittorio , Arancio Angela , Campagna Massimo , Palladino Clelia , Moretti Sonia , Monini Paolo , Brambilla Lucia , Ensoli Barbara
Published: August 2024

Supplementary Table 3 shows the clinical treatment-related AEs by SOC and study phases.
Deventilation Syndrome in Patients with Chronic Obstructive Pulmonary Disease Using Nocturnal Noninvasive Ventilation: What Are the Underlying Mechanisms?
Authors: Elshof Judith , Oppersma Eline , Wisse Jantine J. , Bladder Gerrie , Meijer Petra M. , Torres Abel , Wijkstra Peter J. , Duiverman Marieke L.
Published: August 2024

Introduction: Patients with chronic obstructive pulmonary disease (COPD) commonly experience severe dyspnea after discontinuation of nocturnal noninvasive ventilation (NIV), known as deventilation syndrome (DVS), which negatively affects quality of life. Despite various hypotheses, the precise mechanisms of DVS remain unknown. Methods: An observational pilot study was performed monitoring 16 stable COPD patients before, during, and after an afternoon nap on NIV. Seven patients experienced DVS (Borg Dyspnea Scale ≥5), while nine served as controls (Borg Dyspnea Scale ≤2). Hyperinflation was evaluated through inspiratory capacity (IC) measurements and end-expiratory lung impedance (EELI) via electrical impedance tomography. Respiratory muscle activity was assessed by diaphragmatic surface electromyography (sEMG). Results: Post-NIV dyspnea scores were significantly higher in the DVS group (5 [3–7] vs. 0 [0–1.5], p < 0.001). IC values were lower in the DVS group compared to controls, both pre-NIV (54 [41–63] vs. 88 [72–94] %pred., p = 0.006) and post-NIV (45 [40–59] vs. 76 [65–82] %pred., p = 0.005), while no intergroup difference was seen in IC changes pre- and post-NIV. EELI values after NIV indicated a tendency towards lower values in controls and higher values in DVS patients. sEMG amplitudes were higher in the DVS group within the first 5-min post-NIV (221 [112–294] vs. 100 [58–177]% of baseline, p = 0.030). Conclusion: This study suggests that it is unlikely that DVS originates from the inability to create diaphragmatic muscle activity after NIV. Instead, NIV-induced hyperinflation in individuals with static hyperinflation may play a significant role. Addressing hyperinflation holds promise in preventing DVS symptoms in COPD patients.
A inovação como conceito e base de práticas de gestão: o caso de uma pousada no município de Luís Correa, Piauí, Brasil
Authors: Costa Laura Cristina Afonso , Aires Jussara Danielle Martins
Published: August 2024

Con el fin de colmar lagunas prácticas y académicas, el objetivo de este estudio de caso es investigar conceptos y prácticas que potencien la innovación en el contexto de una posada ubicada en el municipio de Luís Correa (Piauí), señalando estrategias capaces de inspirar a empresarios y actores del sector. Utilizando un enfoque cualitativo y respetando las cuestiones éticas, la investigación incluyó una entrevista en profundidad (grabada y transcrita) con el propietario de la empresa en cuestión, en julio de 2023, utilizando un cuestionario semiestructurado basado en la literatura. Se utilizó la técnica de Análisis de Contenido. Los principales resultados fueron que el concepto de innovación en la percepción del empresario está en línea con la literatura, entendiéndose como una mentalidad capaz de promover novedades, cambios y mejoras significativas que aportan realización personal y retornos financieros. Además, en los últimos tres años, la empresa ha implementado nuevos productos en forma de tours e itinerarios que potencian los diferenciales del destino en el que se encuentra. Para ello, ha establecido asociaciones con empresas comerciales locales; también ha aplicado medidas de reducción de costes y ha adoptado programas informáticos de gestión integrada. Junto con el empresario, se elaboró una matriz en la que se destacaban los puntos fuertes, los puntos débiles, las oportunidades y las amenazas de la empresa, con el fin de orientar la elaboración de un plan de acción. Por último, basándose en el caso estudiado, se sugiere una lista de acciones que pueden seguir las empresas de alojamiento.
Action Planning Renders Objects in Working Memory More Attentionally Salient
Authors: Trentin Caterina , Olivers Chris , Slagter Heleen A.
Published: August 2024

A rapidly growing body of work suggests that visual working memory (VWM) is fundamentally action oriented. Consistent with this, we recently showed that attention is more strongly biased by VWM representations of objects when we plan to act on those objects in the future. Using EEG and eye tracking, here, we investigated neurophysiological correlates of the interactions between VWM and action. Participants (n = 36) memorized a shape for a subsequent VWM test. At test, a probe was presented along with a secondary object. In the action condition, participants gripped the actual probe if it matched the memorized shape, whereas in the control condition, they gripped the secondary object. Crucially, during the VWM delay, participants engaged in a visual selection task, in which they located a target as fast as possible. The memorized shape could either encircle the target (congruent trials) or a distractor (incongruent trials). Replicating previous findings, we found that eye gaze was biased toward the VWM-matching shape and, importantly, more so when the shape was directly associated with an action plan. Moreover, the ERP results revealed that during the selection task, future action-relevant VWM-matching shapes elicited (1) a stronger Ppc (posterior positivity contralateral), signaling greater attentional saliency; (2) an earlier PD (distractor positivity) component, suggesting faster suppression; (3) a larger inverse (i.e., positive) sustained posterior contralateral negativity in incongruent trials, consistent with stronger suppression of action-associated distractors; and (4) an enhanced response-locked positivity over left motor regions, possibly indicating enhanced inhibition of the response associated with the memorized item during the interim task. Overall, these results suggest that action planning renders objects in VWM more attentionally salient, supporting the notion of selection-for-action in working memory.
Working Memory Guides Action Valuation in Model-based Decision-making Strategy
Authors: Zuo Zhaoyu , Yang Li-Zhuang , Wang Hongzhi , Li Hai
Published: August 2024

Humans use both model-free (or habitual) and model-based (or goal-directed) strategies in sequential decision-making. Working memory (WM) is essential for the model-based strategy; however, its exact role in these processes remains elusive. This study investigates the influence of WM processes on decision-making and the underlying cognitive computing mechanisms. Specifically, we used experimental data from two-stage decision tasks and found that delay and load, two WM-specific variables, impact goal-revisiting behaviors. Then, we proposed possible computational mechanisms by which WM participates in information processing and integrated them into the model-based system. The proposed Hybrid-WM model reproduced the observed experimental effects and fit human behavior better than the classic hybrid reinforcement learning model. These results were verified with independent data sets. Furthermore, differences in model parameters explain the age-related difference in sequential decision-making. Overall, this study suggests that WM guides action valuation in model-based strategies, highlighting the contribution of higher cognitive functions to sequential decision-making.
القضايا البلاغية في شرح ابن عقيل على ألفية ابن مالك وأثرها في توجيه المعاني والدلالات القرآنية
Authors: Abedalaziz Maryam , Al-Haj Thabet Abu , Yusoff M. Y. Zulkifli Mohd
Published: August 2024

The aim of this research is to uncover the rhetorical issues in Ibn Aqīl’s explanation of Ibn Malik’s Alfiyyah and their impact on emphasizing the rhetorical significance of the text through the evidence cited in the explanation of Alfiyyah. It explores the extent to which this contributes to understanding the words of Allah Almighty in accordance with their indications and purposes. Ibn Aqīl referenced 264 instances from the Quran in his explanation of Alfiyyah, 164 of which contain rhetorical issues, such as conciseness, anticipation, delay, distinction, connection, definition, negation, indications of meaningful letters, differences in adverbial clauses, and others. The researchers followed a dual methodology combining examination and analysis. They collected Quranic evidence within Ibn Aqīl’s explanation, targeting those associated with rhetorical issues for study, analysis, and deriving benefits and implications. The research concluded that Ibn Aqīl’s explanation contains the fundamentals of rhetoric alongside the rules of grammar. It serves as a foundational rhetorical and grammatical basis related to the Quran, deriving inspiration and relying upon it.
Fairyland-scape: Locus of Retelling and Remembering Ecocentric Tales
Authors: Gülüm Erol
Published: August 2024

This article explores how and why (re)constructions of Fairyland in Earthland can create fairyland-scapes that serve as sites of retelling and remembering ecocentric tales. To conceptualise and theorise the notion of fairyland-scape, the article employs folkloric memory as an approach, fairyland ecology as a method, and fairyland ecosystem as a model. To demonstrate and analyse the various forms and samples of fairyland-scape in practice, the article also examines the interplay between The Grimm Brothers’ Kinder- und Hausmärchen (Children’s and Household Tales) and Die Deutsche Märchenstraße (The German Fairy Tale Route) as a case study.
A new Pseudostaurosira species (Bacillariophyta, Staurosiraceae) from lowland rivers and lakes in Europe (Atlantic Biogeographic Region)
Authors: VAN DE VIJVER BART , WETZEL CARLOS E.
Published: August 2024

During a biomonitoring survey of the Flemish rivers, an unknown Pseudostaurosira taxon was observed. After detailed light and scanning electron microscopy research and careful analysis with similar species in literature, the taxon is described as Pseudostaurosira katharinae sp. nov. The new species can be separated from similar Pseudostaurosira species by its larger sternum and central area, the presence of rings of granules around the spines, the shape and diminishing size of the areolae towards the center and the particular structure of the cingulum. The new species was typically found in meso-eutrophic, alkaline conditions.