bluuebunny/crossref_metadata_2025 huggingface dataset:
Alcohol and Nicotine Use among Adolescents: An Observational Study in a Sicilian Cohort of High School Students
Authors: Cannizzaro Emanuele , Lavanco Gianluca , Castelli Valentina , Cirrincione Luigi , Di Majo Danila , Martines Francesco , Argo Antonina , Plescia Fulvio
Published: May 2022

In recent years, the mode of alcoholic intake known as binge drinking (BD) has become a common practice, especially among adolescents who, due to socio-environmental motives, tend to reach a rapid state of drunkenness. This drunkeness leads to alterations in brain areas responsible for executive functions and cognitive processes, as well as to the genesis of factors that predispose to lasting addiction. Likewise, nicotine leads to a comparable degree of addiction. On this basis, the aim of this research was to evaluate, on a cohort of 349 high school students (15–17 years old) in the province of Palermo, the following: (I) the drinking model of alcoholic beverages; (II) the use of nicotine and the degree of dependence; (III) the correlation between the consumption of alcoholic beverages and the use of nicotine. We employed the AUDIT-C test and the Fagerström test, two valid and standard instruments, in order to assess alcohol and nicotine use, respectively. Statistical analysis of the data showed that male and female students consumed alcohol prominently in a BD mode (77.2%, audit score (AS) 3.497, confidence interval (CI) 3.206–3.788; 69.6%, AS 2.793, CI 2.412–3.274) and nicotine (41.5%, Fagerström score (FS) 3.882, CI 3.519–4.245; 28%, FS 3.286, CI 2.547–4.024). Furthermore, a positive correlation between alcohol consumption and nicotine use was found for male (r = 0.6798, p < 0.0001) and female (r = 0.6572, p < 0.0001) students. This study provided further insights into the use of legal substances of abuse in adolescents, evidencing the obvious need for the promotion of specific school educational programs aimed at the wellbeing of youth populations.
Use of Virtual Reality-Based Therapy in Patients with Urinary Incontinence: A Systematic Review with Meta-Analysis
Authors: Rutkowska Anna , Salvalaggio Silvia , Rutkowski Sebastian , Turolla Andrea
Published: May 2022

It is estimated that over 400 million people worldwide experience some form of urinary incontinence (UI). Pelvic floor muscle training (PFMT) is commonly used in cases of urine loss. Game therapy (GT) has been suggested as a new conservative modality for UI treatments. GT represents a form of virtual reality (VR) that allows users to interact with elements of a simulated scenario. The purpose of this review was to assess the potential of using VR-based PFMT in the treatment of UI with a particular focus on the impact of this form of therapy on the patients’ muscle function, symptoms of UI and quality of life (QoL). The following electronic databases were searched: PubMed, Embase, Cochrane Library, Scopus and Web of Science. Systematic review methods were based on the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) statement. Electronic medical databases were searched from inception to 28 January 2021. From a total of 38 articles, 26 were analyzed after removing duplicates, then 22 records were excluded according to inclusion criteria and 4 were assessed as full texts. Finally, 2 randomized controlled trials (RCT) with 79 patients were included. For the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF), the meta-analysis showed a significant difference in favor of the control condition (MD = 2.22; 95% CI 0.42, 4.01; I2 = 0%). Despite the popularity of the use of VR in rehabilitation, we found a scarcity of literature evaluating the application of VR in the field of UI therapy. Only one study matched all of the criteria established. The effects of VR training improved PFM function and QoL; however, these changes were comparable to those of traditional PFMT. It is not possible to reach final conclusions from one study; thus, further development of VR interventions in the field of UI treatments are needed.
Is There Risk Compensation among HIV Infected Youth and Adults 15 Years and Older on Antiretroviral Treatment in South Africa? Findings from the 2017 National HIV Prevalence, Incidence, Behaviour and Communication Survey
Authors: Zungu Nompumelelo , Mabaso Musawenkosi , Ramlagan Shandir , Simbayi Leickness , Moyo Sizulu , Shisana Olive , Murangandi Pelagia , Igumbor Ehimario , Sigida Salome , Jooste Sean , Marinda Edmore , Ayalew Kassahun , Zuma Khangelani
Published: May 2022

In this paper, risk compensation among individuals on antiretroviral therapy (ART), using the 2017 South African national survey on HIV, is explored. A multi-stage stratified cluster random sampling approach was used to realize 11,130 participants 15 years and older. Logistic regression analysis assessed the association between multiple sexual partners, condom use at last sexual encounter, consistency of condom usage and potential explanatory variables using HIV status and ART exposure as a mediator variable. HIV positive participants who were aware and on ART were less likely to have multiple sexual partners, and less likely not to use a condom at last sex compared to HIV positive participants who were aware but not on ART. The odds of reporting multiple sexual partners were significantly lower among older age groups, females, non-Black Africans, and rural settings, and higher among those with tertiary level education, and risky alcohol users. The odds of no condom use at last sexual encounter were more likely among older age groups, females, other race groups, and less likely among those with secondary level education. The odds of inconsistent condom use were more likely among older age groups, females, and other race groups, and less likely among those with tertiary level education, high risk and hazardous alcohol users. Risk compensation is not apparent among HIV infected adults who are on ART. Risk groups that should receive tailored interventions to reduced risky sexual behaviours were identified.
Piperine Improves Lipid Dysregulation by Modulating Circadian Genes Bmal1 and Clock in HepG2 Cells
Authors: Zhang Weiyun , Ho Chi-Tang , Lu Muwen
Published: May 2022

Metabolic disorders are closely associated with the dysregulation of circadian rhythms. Many bioactive components with lipid metabolism-regulating effects have been reported to function through circadian clock-related mechanisms. As the main pungent principle of black pepper, piperine (PIP) has been demonstrated to possess anti-obesity bioactivity by affecting hepatic lipid metabolism-related factors. However, whether the circadian clock genes Bmal1 and Clock are involved in the protective effect of PIP against lipid metabolism disorders remains unknown. In this work, oleic acid (OA) induced lipid accumulation in HepG2 cells. The effect of PIP on redox status, mitochondrial functions, and circadian rhythms of core clock genes were evaluated. Results revealed that PIP alleviated circadian desynchrony, ROS overproduction, and mitochondrial dysfunction. A mechanism study showed that PIP could activate the SREBP-1c/PPARγ and AMPK/AKT-mTOR signaling pathways in a Bmal1/Clock-dependent manner in HepG2 cells. These results indicated that Bmal1 and Clock played important roles in the regulating effect of PIP on hepatic lipid homeostasis.
From Tissue Physoxia to Cancer Hypoxia, Cost-Effective Methods to Study Tissue-Specific O2 Levels in Cellular Biology
Authors: Nascimento-Filho Carlos H. V. , Glinos Alexandra T. , Jang Yeejin , Goloni-Bertollo Eny M. , Castilho Rogerio M. , Squarize Cristiane H.
Published: May 2022

The human body is endowed with an extraordinary ability to maintain different oxygen levels in various tissues and organs. The maintenance of physiological levels of oxygen is known as physoxia. The development of hypoxic conditions plays an important role in the biology of several pathologies, including cancer. In vitro studies using normal and neoplastic cells require that culture conditions be carried out under appropriate oxygen levels, either physoxic or hypoxic conditions. Such requirements are difficult to widely implement in laboratory practice, mainly due to the high costs of specialized equipment. In this work, we present and characterize a cost-effective method to culture cells under a range of oxygen levels using deoxidizing pouches. Our results show that physoxic and hypoxic levels using deoxidizing absorbers can be achieved either by implementing a gradual change in oxygen levels or by a regimen of acute depletion of oxygen. This approach triggers the activation of an epithelial-mesenchymal transition in cancer cells while stimulating the expression of HIF-1α. Culturing cancer cells with deoxidizing agent pouches revealed PI3K oncogenic pathway exacerbations compared to tumor cells growing under atmospheric levels of oxygen. Similar to the PI3K signaling disturbance, we also observed augmented oxidative stress and superoxide levels and increased cell cycle arrest. Most interestingly, the culture of cancer cells under hypoxia resulted in the accumulation of cancer stem cells in a time-dependent manner. Overall, we present an attractive, cost-effective method of culturing cells under appropriate physoxic or hypoxic conditions that is easily implementable in any wet laboratory equipped with cell culture tools.
Role of Sodium-Glucose Co-Transporter 2 Inhibitors in the Regulation of Inflammatory Processes in Animal Models
Authors: Feijóo-Bandín Sandra , Aragón-Herrera Alana , Otero-Santiago Manuel , Anido-Varela Laura , Moraña-Fernández Sandra , Tarazón Estefanía , Roselló-Lletí Esther , Portolés Manuel , Gualillo Oreste , González-Juanatey José Ramón , Lago Francisca
Published: May 2022

Sodium-glucose co-transporter 2 inhibitors, also known as gliflozins, were developed as a novel class of anti-diabetic agents that promote glycosuria through the prevention of glucose reabsorption in the proximal tubule by sodium-glucose co-transporter 2. Beyond the regulation of glucose homeostasis, they resulted as being effective in different clinical trials in patients with heart failure, showing a strong cardio-renal protective effect in diabetic, but also in non-diabetic patients, which highlights the possible existence of other mechanisms through which gliflozins could be exerting their action. So far, different gliflozins have been approved for their therapeutic use in T2DM, heart failure, and diabetic kidney disease in different countries, all of them being diseases that have in common a deregulation of the inflammatory process associated with the pathology, which perpetuates and worsens the disease. This inflammatory deregulation has been observed in many other diseases, which led the scientific community to have a growing interest in the understanding of the biological processes that lead to or control inflammation deregulation in order to be able to identify potential therapeutic targets that could revert this situation and contribute to the amelioration of the disease. In this line, recent studies showed that gliflozins also act as an anti-inflammatory drug, and have been proposed as a useful strategy to treat other diseases linked to inflammation in addition to cardio-renal diseases, such as diabetes, obesity, atherosclerosis, or non-alcoholic fatty liver disease. In this work, we will review recent studies regarding the role of the main sodium-glucose co-transporter 2 inhibitors in the control of inflammation.
Dielectric Study of Tetraalkylammonium and Tetraalkylphosphonium Levulinate Ionic Liquids
Authors: Kripotou Sotiria , Tsonos Georgios , Mezzetta Andrea , Mero Angelica , Guazzelli Lorenzo , Moutzouris Konstantinos , Stavrakas Ilias , Tsonos Christos
Published: May 2022

Broadband dielectric spectroscopy in a broad temperature range was employed to study ionic conductivity and dynamics in tetraalkylammonium- and tetraalkylphosphonium-based ionic liquids (ILs) having levulinate as a common anion. Combining data for ionic conductivity with data obtained for viscosity in a Walden plot, we show that ionic conductivity is controlled by viscosity while a strong association of ions takes place. Higher values for ionic conductivities in a broad temperature range were found for the tetraalkylphosphonium-based IL compared to its ammonium homolog in accordance with its lower viscosity. Levulinate used in the present study as anion was found to interact and associate stronger with the cations forming ion-pairs or other complexes compared to the NTf2 anion studied in literature. In order to analyze dielectric data, different fitting approaches were employed. The original random barrier model cannot well describe the conductivity especially at the higher frequencies region. In electric modulus representation, two overlapping mechanisms contribute to the broad low frequencies peak. The slower process is related to the conduction mechanism and the faster to the main polarization process of the complex dielectric permittivity representation. The correlation of the characteristic time scales of the previous relaxation processes was discussed in terms of ionic interactions.
Hypoxia-Reoxygenation Impairs Autophagy-Lysosomal Machinery in Primary Human Trophoblasts Mimicking Placental Pathology of Early-Onset Preeclampsia
Authors: Cheng Shibin , Huang Zheping , Jash Sukanta , Wu Kathleen , Saito Shigeru , Nakashima Akitoshi , Sharma Surendra
Published: May 2022

We have previously described that placental activation of autophagy is a central feature of normal pregnancy, whereas autophagy is impaired in preeclampsia (PE). Here, we show that hypoxia–reoxygenation (H/R) treatment dysregulates key molecules that maintain autophagy–lysosomal flux in primary human trophoblasts (PHTs). Ultrastructural analysis using transmission electron microscopy reveals a significant reduction in autophagosomes and autolysosomes in H/R-exposed PHTs. H/R-induced accumulation of protein aggregates follows a similar pattern that occurs in PHTs treated with a lysosomal disruptor, chloroquine. Importantly, the placenta from early-onset PE deliveries exhibits the same features as seen in H/R-treated PHTs. Taken together, our results indicate that H/R disrupts autophagic machinery in PHTs and that impaired autophagy in the placenta from early-onset PE deliveries mimics the events in H/R-treated PHTs. Notably, assessment of key regulators at each stage of autophagic processes, especially lysosomal integrity, and verification of autophagic ultrastructure are essential for an accurate evaluation of autophagy activity in human trophoblasts and placental tissue from PE deliveries.
How Cell Geometry and Cellular Patterning Influence Tissue Stiffness
Authors: Majda Mateusz , Trozzi Nicola , Mosca Gabriella , Smith Richard S.
Published: May 2022

Cell growth in plants occurs due to relaxation of the cell wall in response to mechanical forces generated by turgor pressure. Growth can be anisotropic, with the principal direction of growth often correlating with the direction of lower stiffness of the cell wall. However, extensometer experiments on onion epidermal peels have shown that the tissue is stiffer in the principal direction of growth. Here, we used a combination of microextensometer experiments on epidermal onion peels and finite element method (FEM) modeling to investigate how cell geometry and cellular patterning affects mechanical measurements made at the tissue level. Simulations with isotropic cell-wall material parameters showed that the orientation of elongated cells influences tissue apparent stiffness, with the tissue appearing much softer in the transverse versus the longitudinal directions. Our simulations suggest that although extensometer experiments show that the onion tissue is stiffer when stretched in the longitudinal direction, the effect of cellular geometry means that the wall is in fact softer in this direction, matching the primary growth direction of the cells.
Antibacterial and Osteogenic Properties of Ag Nanoparticles and Ag/TiO2 Nanostructures Prepared by Atomic Layer Deposition
Authors: Nazarov Denis , Ezhov Ilya , Yudintceva Natalia , Shevtsov Maxim , Rudakova Aida , Kalganov Vladimir , Tolmachev Vladimir , Zharova Yuliya , Lutakov Oleksiy , Kraeva Ludmila , Rogacheva Elizaveta , Maximov Maxim
Published: May 2022

The combination of titania nanofilms and silver nanoparticles (NPs) is a very promising material, with antibacterial and osseointegration-induced properties for titanium implant coatings. In this work, we successfully prepared TiO2 nanolayer/Ag NP structures on titanium disks using atomic layer deposition (ALD). The samples were studied by scanning electron microscopy (SEM), X-ray diffraction, X-ray photoelectron spectroscopy (XPS), contact angle measurements, and SEM-EDS. Antibacterial activity was tested against Staphylococcus aureus. The in vitro cytological response of MG-63 osteosarcoma and human fetal mesenchymal stem cells (FetMSCs) was examined using SEM study of their morphology, MTT test of viability and differentiation using alkaline phosphatase and osteopontin with and without medium-induced differentiation in the osteogenic direction. The samples with TiO2 nanolayers, Ag NPs, and a TiO2/Ag combination showed high antibacterial activity, differentiation in the osteogenic direction, and non-cytotoxicity. The medium for differentiation significantly improved osteogenic differentiation, but the ALD coatings also stimulated differentiation in the absence of the medium. The TiO2/Ag samples showed the best antibacterial ability and differentiation in the osteogenic direction, indicating the success of the combining of TiO2 and Ag to produce a multifunctional biocompatible and bactericidal material.
Surface Area of Wood Influences the Effects of Fungal Interspecific Interaction on Wood Decomposition—A Case Study Based on Pinus densiflora and Selected White Rot Fungi
Authors: Fukasawa Yu , Kaga Koji
Published: May 2022

Wood decomposer basidiomycetes are the major agents of lignocellulose decomposition in dead wood. As their interspecific interaction affects wood decomposition, difference in interaction area may alter the magnitude of the effects. This study examines the effects of wood surface area on decomposition by interacting basidiomycetes using laboratory incubation experiments with pine sapwood as a model. Two types of pine wood blocks with equal volume but identical surface area were prepared for colonization by one of four white rot basidiomycete species. The colonized wood blocks were then placed on agar media already colonized by the same strain or one of the other species, simulating fungal monoculture and interspecific interactions on wood surface. Results demonstrated that the decay rate of wood was greater in wood with larger surface, and wood decay was accelerated by the interaction of two fungal species in wood with larger surface but not in wood with smaller surface. In contrast, lignin decomposition was influenced by the competitor in wood with smaller surface but not in wood with larger surface. These results suggest that the observed promotion of decay by fungal interspecific interaction might not be attributable to the resource partitioning between fungal species but to the accelerated carbon of competition cost compensation in this case.
Metabolomics Analysis and Antioxidant Potential of Endophytic Diaporthe fraxini ED2 Grown in Different Culture Media
Authors: Tan Wen-Nee , Nagarajan Kashvintha , Lim Vuanghao , Azizi Juzaili , Khaw Kooi-Yeong , Tong Woei-Yenn , Leong Chean-Ring , Chear Nelson Jeng-Yeou
Published: May 2022

Endophytic fungi are a promising source of bioactive metabolites with a wide range of pharmacological activities. In the present study, MS-based metabolomics was conducted to study the metabolomes variations of endophytic Diaporthe fraxini ED2 grown in different culture media. Total phenolic content (TPC), total flavonoid content (TFC), 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2-azinobis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), and ferric reducing antioxidant power (FRAP) assays were conducted to assess the antioxidant potential of the fungal extracts. Multivariate data analysis (MVDA) was employed in data analysis and interpretation to elucidate the complex metabolite profile. The supplemented culture medium of D. fraxini fungal extract stimulated the production of metabolites not occurring in the normal culture medium. Antioxidant activity studies revealed the potential of supplemented cultured fungal extract of D. fraxini as a source of antioxidants. The present findings highlight that fungal culture medium supplementation is an effective approach to unravelling the hidden metabolome in plant-associated fungal diversity.
Personalized Care in Late-Stage Parkinson’s Disease: Challenges and Opportunities
Authors: Fabbri Margherita , Coelho Miguel , Garon Michela , Biundo Roberta , Mestre Tiago A. , Antonini Angelo ,   on behalf of iCARE-PD Consortium
Published: May 2022

Late-stage Parkinson’s disease (LSPD) patients are highly dependent on activities of daily living and require significant medical needs. In LSPD, there is a significant caregiver burden and greater health economic impact compared to earlier PD stages. The clinical presentation in LSPD is dominated by motor and non-motor symptoms (NMS) that most of the time have a sub-optimal to no response to dopaminergic treatment, especially when dementia is present. Non-pharmacological interventions, including physiotherapy, cognitive stimulation, speech, occupational therapy, and a specialized PD nurse, assume a key role in LSPD to mitigate the impact of disease milestones or prevent acute clinical worsening and optimize the management of troublesome NMS. However, the feasibility of these approaches is limited by patients’ cognitive impairment and the difficulty in delivering care at home. The present care challenge for LSPD is the ability to offer a person-centered, home-delivered palliative care model based on Advanced Care Planning. An ongoing European multicentric project, PD_Pal, aims to address this challenge.
Deep Learning-Based Diagnosis of Alzheimer’s Disease
Authors: Saleem Tausifa Jan , Zahra Syed Rameem , Wu Fan , Alwakeel Ahmed , Alwakeel Mohammed , Jeribi Fathe , Hijji Mohammad
Published: May 2022

Alzheimer’s disease (AD), the most familiar type of dementia, is a severe concern in modern healthcare. Around 5.5 million people aged 65 and above have AD, and it is the sixth leading cause of mortality in the US. AD is an irreversible, degenerative brain disorder characterized by a loss of cognitive function and has no proven cure. Deep learning techniques have gained popularity in recent years, particularly in the domains of natural language processing and computer vision. Since 2014, these techniques have begun to achieve substantial consideration in AD diagnosis research, and the number of papers published in this arena is rising drastically. Deep learning techniques have been reported to be more accurate for AD diagnosis in comparison to conventional machine learning models. Motivated to explore the potential of deep learning in AD diagnosis, this study reviews the current state-of-the-art in AD diagnosis using deep learning. We summarize the most recent trends and findings using a thorough literature review. The study also explores the different biomarkers and datasets for AD diagnosis. Even though deep learning has shown promise in AD diagnosis, there are still several challenges that need to be addressed.
Associations of Complete Blood Count Parameters with Disease-Free Survival in Right- and Left-Sided Colorectal Cancer Patients
Authors: Alsalman Alhasan , Al-Mterin Mohammad A. , Abu-Dayeh Ala , Alloush Ferial , Murshed Khaled , Elkord Eyad
Published: May 2022

Colorectal cancer (CRC) is a leading cause of cancer-related deaths worldwide. Some complete blood count (CBC) parameters are found to be associated with CRC prognosis. In this study, ninety-seven pretreated CRC patients were included, and the patients were divided into two groups: left-sided and right-sided, depending on the anatomical location of the tumor. Based on clinicopathologic features including tumor budding, disease stages, and tumor anatomical location, levels of CBC parameters were compared, and disease-free survivals (DFS) were determined. There were differences between patients with different tumor budding scores for only three parameters, including red cell distribution width (RDW), numbers of platelets, and mean platelet volume (MPV). Furthermore, numbers of WBCs, monocytes, and MPV in CRC patients with early disease stages were higher than those with advanced stages. However, levels of eosinophil in CRC patients with advanced stages were higher than those with early stages. Depending on the tumor anatomical location, we observed that numbers of red blood cells (RBCs), hemoglobin (Hgb), and hematocrit (Hct) in CRC patients with left-sided tumors were higher than those with right-sided tumors. We found that low levels of MPV were associated with shorter DFS. However, high levels of eosinophils were associated with shorter DFS in all CRC patients. When patients were divided based on the tumor anatomical location, higher levels of MPV, MCHC, and Hgb were associated with better DFS in the left-sided but not right-sided CRC patients. However, left-sided, but not right-sided, CRC patients with high levels of eosinophil and RDW had shorter DFS. Furthermore, right-sided, but not left-sided, CRC patients with high levels of platelets tended to have a shorter DFS. Our data show that MPV and eosinophils could serve as potential prognostic biomarkers in pre-treatment CRC patients, regardless of the tumor anatomical location. Additionally, lower levels of MPV, MCHC, and Hgb, and high levels of eosinophils and RDW could be negative predictive biomarkers in left-sided CRC patients.
Early and Late Luteal Executive Function, Cognitive and Somatic Symptoms, and Emotional Regulation of Women with Premenstrual Dysphoric Disorder
Authors: Lin Pai-Cheng , Ko Chih-Hung , Yen Ju-Yu
Published: May 2022

Objective: Cognitive and somatic symptoms were vital factors in developing personalized treatment of depressive disorder. The study aimed to evaluate the following: (1) the cognitive and somatic symptoms of premenstrual dysphoric disorder (PMDD) in the early luteal (EL) and later luteal (LL) phase; and (2) their association with depression and functional impairment of PMDD. Methods: We prospectively evaluated executive function, emotion regulation, cognitive and somatic symptoms, and depression in the EL and LL phases in women with PMDD. Sixty-three women with PMDD and 53 healthy controls completed Simon’s task and questionnaire to assess emotion regulation, inattention, fatigue, insomnia, and depression. Results: Women with PMDD had a poor performance in Simon’s task during the LL phase. They were less likely to exercise cognitive reappraisal during EL and LL phases. Their cognitive reappraisal positively correlated with executive function and negatively associated with depression. In the LL phase, they also experience higher inattention, insomnia, and fatigue, which correlate with the depression and functional impairment of PMDD. Inattention is the most associated factor of PMDD and functional impairment in controlling depression. Conclusion: Executive function was impaired in women with PMDD during the LL phase. Its performance correlated positively with emotion regulation and negatively with depression. The association between inattention and PMDD functional impairment indicates that evaluation and intervention for cognitive impairment were essential in treating women with PMDD. Further studies were required to elucidate the possible etiology underlying these associations.
Volumetric Change in the Masseter and Lateral Pterygoid after Mandibular Setback
Authors: Kang Jae Hyun , Shin Dong Sun , Kim See Woon , Lim Hun Jun , Kim Bong Chul
Published: May 2022

In this study, we evaluated changes in the masseter and lateral pterygoid muscles in the prognathic mandible group after a mandibular setback by comparing the volume-to-length ratios. Preoperative and postoperative 1-year computed tomography was used to calculate the volume-to-length ratio of the lateral pterygoid and masseter muscle in 60 Korean individuals. Three-dimensional images were reconstructed, the results of which showed no significant differences in the volume-to-length ratios of the masseter and lateral pterygoid muscles after a mandibular setback (p > 0.05). This result was found for both vertical ramus osteotomy and sagittal split ramus osteotomy, and for both males and females. No significant differences in the volume-to-length ratio of the masseter and lateral pterygoid muscles were found up to 1 year after a mandibular setback. Therefore, this study can contribute to the prediction of soft-tissue profiles after mandibular setback.
Green Insurance: A Roadmap for Executive Management
Authors: Stricker Lukas , Pugnetti Carlo , Wagner Joël , Zeier Röschmann Angela
Published: May 2022

Anthropogenic climate change is accelerating, and severe and widespread consequences are expected in many areas. Although the insurance sector is not closely associated with any of the sustainability dimensions, expectations may change rapidly. Against this background, we analyze the role of insurers, especially in the property and casualty areas, in addressing the environmental and climate risk challenges and developing a truly sustainable, environmentally friendly business model—green insurance. Building on the Principles of Sustainable Insurance set by the United Nations, we develop a comprehensive roadmap along the insurance value chain for executive management to design their company’s sustainability efforts, with special focus on property and casualty. The roadmap indicates actions to be taken as well as metrics to be managed in product development, marketing and sales, risk management and underwriting and operations and claims management towards green insurance. The existing products, risk appetite and operational processes must be reviewed to support sustainability goals and include the full portfolio of activities, including claims. The time to act is now, the sustainability journey is complex and the proposed business model transformation should provide benefits for early movers.
Multilingualism in the North: From Baklava to Tre Kronor
Authors: Cocq Coppélie , Granstedt Lena , Lindgren Eva , Lindgren Urban
Published: May 2022

This article explores processes of place-making through the study of the linguistic landscape of a small-size town in Northern Sweden. The analysis of signs is used as a tool for examining the role and visibility of actors in the landscape. For this purpose, we examine who the authors are, what forms of multilingualism can be observed, and who has agency in the place-making of the public space. Our documentation consists of photos and fieldnotes from observations, encounters, and conversations with people during ethnographic fieldwork in 2019. Using a mixed-methods approach, all signs were first analysed quantitatively according to the categories of authors and function. Regression analysis was used to explore correlations between the categories. Secondly, multilingual signs were analysed qualitatively regarding their function and purpose in relation to their contexts. Our results illustrate a city centre with a strong presence of the Swedish language. Multilingual signs target specific groups and are intended for information, advertisement, rules and regulations; moreover, our findings indicate that the opportunities for private actors to influence the linguistic landscape are limited. The form of multilingualism in this context—visible multilingualism present mainly through English—is different from the one we can see in the socio-demographic data.
Nanoparticles: Synthesis and Their Role as Potential Drug Candidates for the Treatment of Parasitic Diseases
Authors: Bajwa Hammad Ur Rehman , Khan Muhammad Kasib , Abbas Zaheer , Riaz Roshan , Rehman Tauseef ur , Abbas Rao Zahid , Aleem Muhammad Tahir , Abbas Asghar , Almutairi Mashal M. , Alshammari Fahdah Ayed , Alraey Yasser , Alouffi Abdulaziz
Published: May 2022

Protozoa, helminths and ectoparasites are the major groups of parasites distributed worldwide. Currently, these parasites are treated with chemotherapeutic antiprotozoal drugs, anti-helminthic and anti-ectoparasitic agents, but, with the passage of time, resistance to these drugs has developed due to overuse. In this scenario, nanoparticles are proving to be a major breakthrough in the treatment and control of parasitic diseases. In the last decade, there has been enormous development in the field of nanomedicine for parasitic control. Gold and silver nanoparticles have shown promising results in the treatments of various types of parasitic infections. These nanoparticles are synthesized through the use of various conventional and molecular technologies and have shown great efficacy. They work in different ways, that include damaging the parasite membrane, DNA (Deoxyribonucleic acid) disruption, protein synthesis inhibition and free-radical formation. These agents are effective against intracellular parasites as well. Other nanoparticles, such as iron, nickel, zinc and platinum, have also shown good results in the treatment and control of parasitic infections. It is hoped that this research subject will become the future of modern drug development. This review summarizes the methods that are used to synthesize nanoparticles and their possible mechanisms of action against parasites.
Tetraethylammonium tribromo(triphenylphosphine)nickelate(II)
Authors: Baril-Robert François , Bélanger-Desmarais Nicolas , Reber Christian
Published: May 2022

The crystal structure and vibrational spectra of the tetraethylammonium salt of tribromotriphylphosphinonickel(II) is reported. Br-Ni-Br angles vary between 108° and 121°, deviating from perfect tetrahedral angles.
State of Prestressing Analysis of 62-Year-Old Bridge
Authors: Kralovanec Jakub , Bahleda Frantisek , Moravcik Martin
Published: May 2022

Ageing infrastructure leads to the need for a proper assessment and final decisions considering its state. In the case of prestressed concrete structures, knowledge of the residual state of prestressing is the crucial factor. Therefore, reliable diagnostic techniques for determining the residual value of the prestressing force are needed. This information is subsequently used in the process of the quantification of the load-carrying capacity and remaining service life of prestressed concrete structures. The presented paper introduces an evaluation of a monolithic 62-year-old prestressed concrete bridge, which was built in 1959. The assessment was carried out as a result of concerns after exposure of the anchorage area of the bridge, which was executed during the construction of the new system of anti-flood barriers in the town of Banska Bystrica in central Slovakia. Therefore, the diagnostic survey and subsequent determination of the residual prestressing force included the application of the saw-cut method, the structural response method, and the Barkhausen noise technique. Finally, the experimental program supported by numerical analysis provided information about the actual state of prestressing in the bridge. Results of performed analysis suggested that the state of prestressing of the bridge in question does not significantly differ from the expected level of prestressing after 62 years of service. Subsequently, obtained conclusions enabled the determination of the load-carrying capacity for future use in the form of a pedestrian bridge.
Experimental Study on Mechanical Properties of Root–Soil Composite Reinforced by MICP
Authors: Zheng Xuegui , Lu Xinyu , Zhou Min , Huang Wei , Zhong Zhitao , Wu Xuheng , Zhao Baoyun
Published: May 2022

Mechanical properties of undisturbed root–soil composites were investigated through direct shear tests under different cementation concentrations by microbially induced carbonate precipitation (MICP). The results show that MICP has a significant strengthening effect on the undisturbed root–soil composite, and the maximum shear strength increases by about 160% after grouting. The shear strength of root–soil composites increases with the increase in calcium chloride concentration, and the shear strength increases the most when the concentration is 0.75M. Calcium carbonate formed by MICP treatment has cementitious properties, which increases the cohesion and internal friction angle of the root–soil composite by about 400% and 120%, respectively. The results show that it is feasible to solidify slope and control soil erosion together with microbial and vegetation roots. The research results can serve as a scientific basis and reference for the application of MICP technology in vegetation slope protection engineering.
Effects of Reinforcement Corrosion and Sustained Load on Mechanical Behavior of Reinforced Concrete Columns
Authors: Li Qiang , Dong Zheng , He Qi , Fu Chuanqing , Jin Xianyu
Published: May 2022

The effects of reinforcement corrosion and sustained axial load on mechanical performance of reinforced concrete (RC) columns were investigated in the present study. Three different degrees of reinforcement corrosion were achieved by controlling the durations of accelerated corrosion test (i.e., 16 days, 31 days, and 63 days). Three levels of sustained axial load (i.e., 0%, 30%, and 60% of the ultimate bearing capacity) were concentrically applied on column specimens. The impressing current and the sustained load were applied on column specimens simultaneously, mimicking the degradation of RC columns in real structures. Results indicated that transverse stirrups yielded higher corrosion degree than that of the longitudinal rebar under identical duration of accelerated corrosion test. The application of sustained axial load improved the performance of corroded RC columns in terms of the reinforcement corrosion, the ultimate axial load, as well as the stiffness. Additionally, more longitudinal cracks along the main rebar were exhibited for column specimens subjected to sustained axial load. For both loaded and unloaded column specimens, corrosion of reinforcing steels exacerbated the mechanical deterioration of RC columns, lowering the ultimate load carrying capacity and the axial deformation compared to the uncorroded columns.
Physical Properties and Storage Stability of Buton Rock Asphalt Modified Asphalt
Authors: Su Yue , Hu Xiaodi , Wan Jiuming , Wu Shaopeng , Zhang Yinglong , Huang Xing , Liu Zhangjun
Published: May 2022

Buton Rock Asphalt (BRA) refers to the natural rock asphalt natively produced on the Buton island of Indonesia. It is often used as a modifier to enhance the performance of asphaltpavement. However, the segregation of BRA in BRA-Modified Asphalt (BRA-MA) has restricted its application. This study aims to investigate how the particle size and content of BRA affect the physical properties and storage stability of BRA-MA. Penetration, softening point, viscosity, and viscosity-temperature susceptibility (VTS) were analyzed. The evaluation method of storage stability was discussed and determined. The segregation of BRA in BRA-MA of static storage and transportation process were simulated and tested. The results suggest that the softening point and viscosity were positively correlated to BRA content and inversely determined by particle size. Penetration, VTS, and ductility were reduced due to the decline in particle size and increment of BRA content. The index of segregation value based on viscosity difference showed better statistical and quantitative significances than the softening-point difference in evaluating the storage stability. The particle size and content of BRA are positively correlated to the segregation of BRA-MA. Both the storage temperature and time were positively correlated to the segregation of BRA-MA. We prove that the relationship between specific surface area and segregation are power functional. BRA-MA with BRA whose 50% particle sizes are lower than 13.6 μm showed low segregation in transportation.
Ab Initio Study on Dopant Relaxation Mechanism in Ti and Ce Cationically Substituted in Wurtzite Gallium Nitride
Authors: Alkhedher Mohammad , Majid Abdul , Bulut Niyazi , Elkhatib Samah Elsayed
Published: May 2022

The changes in properties of materials upon introduction of impurities is well documented but less is known about the location of foreign atoms in different hosts. This study is carried out with the motivation to explore dopant location in hexagonal GaN using density functional theory based calculations. The dopant site location of the individual dopants Ti, Ce, and Ti-Ce codoped wurtzite GaN was investigated by placing the dopants at cationic lattice sites as well as off-cationic sites along the c-axis. The geometry optimization relaxed individual dopants on cationic Ga sites but in the case of codoping Ce settled at site 7.8% away along [0001 ¯] and Ti adjusted itself at site 14% away along [0001] from regular cationic sites. The analysis of the results indicates that optimized geometry is sensitive to the starting position of the dopants. The magnetic exchange interactions between Ti and Ce ions are responsible for their structural relaxation in the matrix.
Temperature in the Friction Couple Consisting of Functionally Graded and Homogeneous Materials
Authors: Yevtushenko Aleksander , Kuciej Michał , Topczewska Katarzyna , Zamojski Przemysław
Published: May 2022

An analytical model was developed to determine the temperature of friction coupling, in which one element was made of a functionally graded material (FGM) and the other was homogeneous. First, for such a system, the boundary–value problem of heat conduction was formulated with consideration of the heat generation due to friction. Then, using the Laplace integral transform, an exact solution to this problem was obtained for uniform sliding, and braking with constant deceleration. A numerical analysis was performed for the selected friction pair consisting of the FGM (zircon dioxide + titanium alloy) and cast iron. It was established that the use of elements made of a FGM consisting of ZrO2 and Ti-6Al-4V can significantly reduce the maximum temperature achieved in the friction system.
Nanoparticles of Bioactive Metals/Metal Oxides and Their Nanocomposites with Antibacterial Drugs for Biomedical Applications
Authors: Shabatina Tatyana , Vernaya Olga , Shumilkin Aleksei , Semenov Alexander , Melnikov Mikhail
Published: May 2022

The increasing appearance of new strains of microorganisms resistant to the action of existing antibiotics is a modern problem that requires urgent decision. A promising potential solution is the use of nanoparticles of bioactive metals and their oxides as new antibacterial agents, since they are capable of affecting pathogenic microorganisms by mechanisms different from the mechanisms of action of antibiotics. Inorganic nanoparticles possess a wide spectrum of antibacterial activity. These particles can be easily conjugated with drug molecules and become carriers in targeted drug-delivery systems. This paper discusses the benefits and prospects of the application of nanoparticles from metals and metal oxides and their nanocomposites with antibacterial drugs.
Experimental Investigation of Temperature and Contact Pressure Influence on HFI Welded Joint Properties
Authors: Egger Christian , Kroll Martin , Kern Kerstin , Steimer Yannik , Schreiner Michael , Tillmann Wolfgang
Published: May 2022

This paper presents an experimental electro-thermo-mechanical simulation of high-frequency induction (HFI) welding to investigate the effect of temperature and contact normal stress on the weld seam quality. Therefore welding experiments at different temperatures and contact pressures are performed using flat specimens of 34MnB5 steel sheet. In order to characterize the weld seam strength of the welded specimens, tensile and bending tests are performed. To obtain a relative weld seam strength, the bending specimens were additionally hardened prior to testing. With the hardened specimens, it can be shown that the weld seam strength increases with increasing temperature and contact normal stress until a kind of plateau is formed where the weld seam strength remains almost constant. In addition to mechanical testing, the influence of the investigated process parameters on the weld seam microstructure is studied metallographically using light optical microscopy, scanning electron microscopy, EBSD and hardness measurements. It is shown that the weld seam strength is related to the amount of oxides in the bonding line.
Use of Bacteria to Activate Ground-Granulated Blast-Furnace Slag (GGBFS) as Cementless Binder
Authors: Yum Woo Sung , Do Jinung
Published: May 2022

Ground-granulated blast-furnace slag (GGBFS) can be used as a cementless binder after activation. Recent approaches to activate GGBFS have focused on chemical methods that use NaOH, KOH, and CaO. This study introduces the use of bacteria to activate GGBFS as a biological approach. The presence of bacteria (volumetric ratio), curing temperature (23 °C and 60 °C), and number of curing days (3, 7, and 28 d) are investigated. The use of urea is considered owing to the possibility of calcium carbonate formation. The activated GGBFS is evaluated in the form of a cube (5 cm × 5 cm × 5 cm) for its strength, mineral identification, and pore size distribution. A brick (19 cm × 9 cm × 5.7 cm) is prefabricated to see the feasibility of commercializing bacteria-activated GGBFS based on water absorption and strength measurements. All results are compared with those of water-activated GGBFS. The results indicate that the use of urea inhibits the strength improvement of bacteria-activated GGBFS. Bacterial suspension enhances the GGBFS strength at a curing temperature of 60 °C. Mineral identification tests show that the strength increase is primarily due to the formation of calcite. The compressive strength satisfies the commercial standard of concrete bricks; however, the water absorption rate must be resolved.
Design of a Practical Metal-Made Cold Isostatic Pressing (CIP) Chamber Using Finite Element Analysis
Authors: Song Wentao , Cui Weicheng
Published: May 2022

The fast development of deep-ocean engineering equipment requires more deep-ocean pressure chambers (DOPCs) with a large inner diameter and ultra-high-pressure (UHP). Using the pre-stressed wire-wound (PSWW) concept, cold isostatic pressing (CIP) chambers have become a new concept of DOPCs, which can provide 100% performance of materials in theory. This paper aims to provide a comprehensive design process for a practical metal-made CIP chamber. First, the generalized design equations are derived by considering the fact that the cylinder and wire have different Young’s moduli and Poisson’s ratios. Second, to verify the theory and the reliability of the CIP chamber, the authors proposed a series of FEA models based on ANSYS Mechanical, including a two-dimensional (2D) model with the thermal strain method (TSM) and a three-dimensional (3D) model with the direct method (DM). The relative errors of the pre-stress coefficient range from 0.17% to 5%. Finally, the crack growth path is predicted by using ANSYS’s Separating Morphing and Adaptive Remeshing Technology (SMART) algorithm, and the fatigue life is evaluated by using the unified fatigue life prediction (UFLP) method developed by the authors’ group. This paper provides a more valuable basis to the design of DOPCs as well as to the similar pressure vessels than the previous work.