bluuebunny/crossref_metadata_2025 huggingface dataset:
West’s role in the development of Ukraine
Authors: Zhiltsov S. S.
Published: November 2020

The collapse of the USSR pushed Ukraine for pursuing a policy aimed at expanding cooperation with Western countries. Ukraine placed great emphasis on economic cooperation with the EU and United States, as well as financial assistance from Western countries and international financial organizations, primarily the International Monetary Fund (IMF). Such interest in collaborating with the IMF was driven by the needs of the Ukrainian economy to solve current social and economic problems, maintain the political stability for the elites in power. The increased focus of the Ukrainian side on external financial assistance related to the Ukraine failure to address economic challenges, appeared after the collapse of the USSR, and initiate a new foreign economic policy. The inefficiency of the economy was aggravated by clear-cut governmental policy deficiency. At the same time, Ukraine continued to open up the country to Western capital. This weakened Ukraine’s position on world markets, negatively affected its economic potential. Hence, Ukraine went in for cooperation with the IMF to gain financial assistance and tackle its economic problems. On the other hand, the IMF showed great attention to Ukraine, granting funds to Ukraine as a part of cooperation programs but setting economic conditions and political demands. The ongoing borrowing policy has led to Ukraine foreign debt increase, triggering the dependence of the Ukrainian authorities on the IMF. In recent years, under the new President of Ukraine V. Zelensky, Ukraine has proceeded with the policy of cooperation with the IMF.
“Children’s” Eco-strikes as a Technology for the Formation of a New World Order and Russia’s Interests
Authors: Pashkovsky P. I. , Kryzhko E. V.
Published: November 2020

The phenomenon of «children’s» movements has historical analogs, which traditionally were the result of thoughtful technologies of adults, which were aimed at realizing their interests and achieving specific goals. The use of geopolitical and civilizational approaches has led to the consideration of the phenomenon of «children’s» eco-strikes as a political technology of the initiators of a New World Order. The genesis, essence and purpose of the «Greta Thunberg project» and mass environmental actions in the context of the formation of a New World Order and the interests of Russia have been characterized. It is shown that the initiators of this technology are the «old» globalist and neoliberal elites of Western states, part of the American establishment, international big capital and powerful corporations in the non-material digital sphere. To achieve their goals of neutralizing opponents in the economic and political spheres, they use the protest potential of the «greens», which over the past few decades have actually become part of the Western neoliberal elite. In the context of efforts to create a New World Order, these actors seek to maintain and strengthen their power, continue to exploit third world countries, suppress existing anti-system movements and weaken their main geopolitical competitors – mainly China and Russia, which are looking for safe transport routes and new sources of resources. Therefore, on the initiative of the globalist and neoliberal elites, projects are being put forward to create ecozones in resource-rich «disputed areas» and, as a result, to preserve the prospects for economic activity there. The image of «children’s» eco-strikes, which is presented by the media, reproduces a new social idea and stimulates support from the electorate for the purpose of the transformation of the World Order, which is confirmed by the fact that the movement is massive in various countries of the world. Youth strikes with environmental slogans help to shift the dominant positions from the traditional industrial-resource elite to the digital elite, opening up new financial and economic opportunities and prospects for global leadership for the latter. The intensification of this movement coincided in time with the USA claims to the Northern Sea Route and the development of Arctic resources, which directly affects the interests of Russia.
Central Asian States: Difficulties on the Path of Rapprochement
Authors: Akunova G. Ch.
Published: November 2020

After the collapse of the Soviet Union, the new independent states of Central Asia had faced serious problems, such as the lack of experience in building state system, border demarcation, severe economic situation, threat of interethnic conflicts. However, that period was appropriate for integration initiatives in Central Asia. The economies of the post-Soviet republics in the region had been formed by the common Soviet system, the states depended from each other. In addition, the geopolitical situation in the region was favorable for rapprochement; Russia, China, the United States were not actively involved in regional processes. In the period from 1994 to 2005, the Central Asian republics initiated several integration projects, such as the Common economic space (Kazakhstan, Uzbekistan, and Kyrgyzstan), the Central Asian Economic Community (Kazakhstan, Uzbekistan, Kyrgyzstan and Tajikistan), the Central Asian Cooperation Organization (all republics of Central Asia, except Turkmenistan). It should be noted that the integration process in the region implied all republics of Central Asia, except Turkmenistan, which had been ignoring any initiatives of neighbor countries. These structures did not achieve their goal, such as the creation of a free trade zone as well as customs, currency and payment unions. After a prolonged period of integration initiatives, there were no real close relationships between the countries. The states still prefer to build their relations in a bilateral format. The article considers the reasons that prevent the Central Asian states from effectively pursuing a multilateral format of cooperation in the region. The main reasons that determine the unpreparedness of Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan for cooperation in a multilateral format are identified. Attention has been paid to such factors as the collision of interests of outside players, leadership issues between Kazakhstan and Uzbekistan, water distribution policy and cross-border cooperation. The steps that Central Asian countries need to take to establish effective multilateral cooperation in the region are analyzed.
Memahami perilaku kemandirian belajar Siswa melalui perspektif Human Agency: Sintesis perspektif Human Agency
Authors: Alfaiz Alfaiz , Kadafi Asroful , Yuzarion Yuzarion , Aulia Rahmadianti , Suarja Septya , Mulyani Rila Rahma , Chandra Yasrial , Adison Joni
Published: November 2020

Human agency adalah konsep bahwa seorang individu memiliki kompetensi dalam perencanaan, disiplin, realisasi dan mengevaluasi perilaku mereka sendiri dalam keadaan hidup termasuk dalam pembelajaran. Ini telah dipelajari dalam pendidikan dengan empat sifat inti seperti sengaja, pemikiran, reaktivitas diri, dan reflektifitas diri membentuk individu sebagai aktor, bukan reaktor. Hal ini dapat digunakan untuk memahami pembelajaran mandiri siswa, karena konsep pembelajaran mandiri memiliki kesadaran diri secara sengaja. Jika individu selalu bergantung pada lingkungannya, itu karena ia tidak memiliki agen dalam keadaan hidupnya. Menurut sebuah penelitian terbaru yang dilakukan pada tahun 2012, telah menemukan bahwa seorang siswa memiliki kurang otonom dalam belajar, dan juga dari survei yang dilakukan pada 2017-2019 ditemukan bahwa 61,50% siswa di 4 sekolah menengah atas memiliki pembelajaran mandiri yang lebih rendah. Fenomena ini mempengaruhi perilaku selingkuh dan menunda-nunda mereka. Pada artikel ini akan membahas kondisi siswa dalam belajar dan memberikan rekomendasi baru dalam perspektif tentang intervensi alternatif dalam praktik bimbingan dan konseling tentang agensi manusia untuk membentuk dan memahami perilaku belajar mandiri dan juga sifat internalisasi agensi manusia dalam proses konseling dalam konteks dalam belajar.Abstract: Human agency is a concept that an individual has a competencies in planning, discipline, realization and evaluate their own behavior in life circumstanceÂ including in learning. It has been studied in education with four core properties such intentionally, forethought, self-reactiveness, and self-reflectivenessÂ shape an individual as an actor, notÂ a reactor. It can be usedÂ to understanding a student autonomous learning, because the concept of autonomous learningÂ has aÂ self-cognition purposely. If individual always dependsÂ on their environment, that because he does not haveÂ an agentic in his life circumstance. According a latestÂ research that conductsÂ in 2012, has found that a studentÂ has a lack of autonomous in learning, and also from survey that conduct in 2017-2019 itâ€™s found that 61,50% students in 4 senior high school has lower autonomous learning. This phenomena influence to their cheating and procrastination behavior. On this article will discuss a studentâ€™s condition in learning and gives a new recommendation in perspectiveÂ about alternative intervention in guidance and counseling practice about the humanÂ agency to shape and understanding an autonomous learning behaviorÂ and also internalization properties of human agency in counseling process in the contextÂ in learning.
Transcriptional profiling of iPSC-derived neurons with reciprocal monogenic CNV in 3p26.3 region
Authors: Лопаткина М.Е. , Фишман В.С. , Гридина М.М. , Скрябин Н.А. , Никитина Т.В. , Кашеварова А.А. , Назаренко Л.П. , Серов О.Л. , Лебедев И.Н.
Published: November 2020

Проведен анализ генной экспрессии в нейронах, дифференцированных из индуцированных плюрипотентных стволовых клеток пациентов с идиопатическими интеллектуальными нарушениями и реципрокными хромосомными мутациями в регионе 3p26.3, затрагивающими единственный ген CNTN6. Для нейронов с различным типом хромосомных аберраций была показана глобальная дисрегуляция генной экспрессии. В нейронах с вариациями числа копий гена CNTN6 была снижена экспрессия генов, продукты которых вовлечены в процессы развития центральной нервной системы.

The gene expression analysis of iPSC-derived neurons, obtained from patients with idiopathic intellectual disability and reciprocal microdeletion and microduplication in 3p26.3 region affecting the single CNTN6 gene was performed. The global gene expression dysregulation was demonstrated for cells with CNTN6 copy number variation. Gene expression in neurons with CNTN6 copy number changes was downregulated for genes, whose products are involved in the central nervous system development.
Meiotic nonhomologous coorientation in man
Authors: Ковалева Н.В.
Published: November 2020

Концепция мейотической коориентаци негомологичных хромосом (МКНХ) как модели мейоза, экспериментально подтвержденная на Drosophila, была предложена в 1971 г. для объяснения интерхромосомного эффекта у человека, но с тех пор не получила достаточных доказательств. Представленные в настоящей статье данные «неканонического» поведения половых хромосом в определенных ситуациях являются основанием для признания существования этого явления в сперматогенезе человека.

The concept of meiotic co-orientation of non-homologous chromosomes as a model of meiosis, experimentally confirmed in Drosophila, was proposed in 1971 to explain the interchromosomal effect in humans, but has not received sufficient evidence since. The data of the “non-canonical” behavior of sex chromosomes presented in this article are the basis for recognizing the existence of this phenomenon in human spermatogenesis.
Discordance of karyotypes in chorionic villus cells by autosome aneuploidy
Authors: Головатая Е.И.
Published: November 2020

Представлены исходы беременностей и результаты цитогенетических исследований 50 случаев дискордантности кариотипов по трисомиям аутосом при получении нормального кариотипа в клетках трофобласта или мезенхимальной стромы ворсин.

Pregnancy outcomes and results of cytogenetic studies of 50 cases of autosome trisomy karyotype discordance in obtaining a normal karyotype in trophoblast cells or villi mesenchymal stroma are presented.
Prenatal diagnosis of oral-facial-digital type I syndrome in a fetus with partial monosomy of Xp22.2
Authors: Минайчева Л.И. , Сеитова Г.Н. , Филиппова М.О. , Кашеварова А.А. , Скрябин Н.А. , Лопаткина М.Е. , Яковлева Ю.С. , Назаренко Л.П. , Лебедев И.Н.
Published: November 2020

Представлен первый случай пренатальной диагностики оро-фацио-дигитального синдрома I типа (OMIM 311200) у плода с частичной моносомией Хр22.2. Причиной оро-фацио-дигитального синдрома I типа являются мутации в гене OFDI, случаи заболевания вследствие хромосомных микроделеций, затрагивающих ген OFDI встречаются редко. При ультразвуковом исследовании плода во втором триместре беременности выявлены врожденный порок развития головного мозга и множественные эхографические маркеры хромосомной и синдромальной патологии. Биологический образец плода (пуповинная кровь) получен в 21 неделю гестации посредством кордоцентеза. Молекулярно-цитогенетический анализ ДНК, выделенной из лимфоцитов пуповинной крови плода, с применением матричной сравнительной геномной гибридизации выявил частичную моносомию региона Хр22.2, размером 2,6 млн п.н.: arr[hg19] Xp22.2(11135472_13798048)×1. Наличие перестройки, а также ее de novo происхождение, подтверждено количественной ПЦР в режиме реального времени.

The first case of prenatal diagnosis of type I oro-facio-digital syndrome (OMIM 311200) in fetus with partial monosomy Xp22.2 is presented. The cause of type I oro-facio-digital syndrome is mutations in the OFDI gene, cases of disease due to chromosomal microdeletions affecting the OFDI gene are rare. Ultrasound examination of the fetus in the second trimester of pregnancy revealed congenital defect of brain development and multiple echographic markers of chromosomal and syndrome pathology. An umbilical cord blood was obtained in 21 weeks of gestation by cordocentesis. aCGH revealed partial monosomy Xp22.2 at 2.6 Mb in size: arr [hg19] Xp22.2(11135472_13798048) × 1. The presence of microdeletion, as well as its de novo origin, was confirmed by the quantitative real time PCR. The use of high-resolution molecular cytogenetic analysis significantly expands the possibilities of syndrome monogenic pathology diagnosis in the prenatal period.
Сomparative genomic hybridization in prenatal diagnosis
Authors: Гнетецкая В.А. , Тарасова Ю.А. , Кузнецова Е.С. , Ермакова М.А. , Ижевская В.Л.
Published: November 2020

Молекулярное кариотипирование в нашем исследовании показало увеличение выявляемости хромосомных аберраций на 6,4% по сравнению c классическими цитогенетическими методами, однако для определения и/или уточнения природы микроскопических или субмикроскопических аномалий и для выявления сбалансированных перестроек необходимо их совместное применение.

Molecular karyotyping in our study showed a 6.4% increase in the detectability of chromosomal aberrations compared to classical cytogenetic methods, but their combined application is necessary to determine and/or clarify the nature of microscopic or submicroscopic anomalies and to identify balanced rearrangements.
A survey of pregnant women about their preferences for prenatal tests with different characteristics
Authors: Баранова Е.Е. , Заяева Е.Е. , Жученко Л.А. , Щелыкалина С.П. , Ижевская В.Л.
Published: November 2020

Проанализировано мнение 800 беременных женщин, проходящих ранний пренатальный скрининг (РПС) врожденных пороков развития и хромосомных аномалий у плода, относительно различных характеристик пренатальных тестов Проведенный опрос позволит сравнить результаты с другими странами, где НИПТ используется в РПС, и выработать собственные рекомендации.

Relatively different characteristics of prenatal tests, the opinion of 800 pregnant women undergoing early prenatal screening (EPS) of congenital malformations and chromosomal abnormalities in the fetus was analyzed. The survey will allow you to compare the results with other countries where NIPT is used in the EPS, and to develop our own recommendations.
Modern opportunities and approaches to diagnosis of genetic male infertility
Authors: Сорокина Т.М. , Курило Л.Ф. , Черных В.Б.
Published: November 2020

Рассмотрены современные возможности медико-генетического обследования мужчин с нарушением фертильности, а также приведены показания и алгоритмы диагностики генетических причин мужского бесплодия, связанного с различными формами патозооспермии.

The current possibilities of a genetic examination of infertile men, as well as indications and diagnostic algorithms for the genetic causes of male infertility associated with various forms of pathozoospermia are presented.
The influence of Robertsonian translocations on semen parameters
Authors: Андреева М.В. , Штаут М.И. , Сорокина Т.М. , Курило Л.Ф. , Черных В.Б.
Published: November 2020

Обследованы 19 мужчин с нарушением фертильности, носителей транслокаций rob(13;14) и rob(13;15). Показано, что нарушение репродуктивной функции обусловлено блоком сперматогенеза в профазе I мейоза, приводящего к азооспермии или олигоастенотератозооспермии и мужскому бесплодию.

We examined 19 infertile men, carriers of translocations rob (13;14) and rob (13;15). We assume that fertility problems are resulted from spermatogenesis impairment because of meiotic arrest at prophase I stages, that leads to azoospermia or oligoastenoteratozoospermia and male infertility.
Chronic systemic inflammation in pathways of metabolic syndrome associated with hyperandrogenism (review)
Authors: Игумнов И.А. , Шарифулин Э.М. , Беленькая Л.В. , Лазарева Л.М. , Аталян А.В. , Вильсон Н.И. , Сутурина Л.В.
Published: November 2020

Данная статья представляет собой обзор публикаций по проблеме хронического системного воспаления (ХСВ) и его роли в патогенезе метаболического синдрома (МС), в частности, ассоциированного с гиперандрогенизмом (ГА). Цель: систематизация имеющихся данных о роли хронического системного воспаления в патогенезе метаболических осложнений гиперандрогенизма. Информационный поиск проводился с использованием интернет ресурсов (PubMed, EMBASE, Google Scholar, E-library), анализировались литературные источники за период 2000-2020 гг. В обзоре отражены современные представления о ХСВ и МС; описаны основные ассоциации МС и ГА. Продемонстрировано, что синдром поликистоза яичников (СПКЯ), как и МС, ассоциирован с ХСВ, инсулинорезистентностью и ожирением. При этом отмечено, что установить причинно-следственный характер данной связи не всегда представляется возможным. В заключительной части обзора обобщены сведения о наиболее значимых маркерах ХСВ, специфичных для МС и ГА.

This review addresses aspects of chronic systemic inflammation and its role in the pathogenesis of metabolic syndrome (MS) associated with hyperandrogenism (HA). The objective of this review was to systematize available data on the role of chronic systemic inflammation in the pathogenesis of metabolic complications of hyperandrogenism. Search for information was performed in the PubMed, EMBASE, Google Scholar, and E-library databases; 2000-2020 information was analyzed. The article presents the current view on chronic systemic inflammation and MS; major associations of MS and hyperandrogenism (HA) are also described. Polycystic ovary syndrome (PCOS), as well as MS, was shown to be associated with chronic systemic inflammation, insulin resistance, and obesity. However, it is not always possible to establish the causal nature of this relationship. The final part of the review summarizes information about the most significant markers of chronic systemic inflammation, which are specific for MS and HA.
Pathological processes of immunological decontamination of herpes simplex virus type 1 from the cornea
Authors: Керимов Т.З. , Соболев В.П. , Соболева М.А. , Гаврилова Н.А. , Борзенок С.А.
Published: November 2020

В обзоре представлено описание патофизиологических механизмов герпесвирусной инфекции. Согласно данным медицинской статистики, вирусом простого герпеса 1 типа инфицировано большинство населения планеты. В развивающихся странах данный вирус является ведущей инфекционной причиной поражения роговицы. Также вирусу простого герпеса 1 типа отводится роль одного из факторов, приводящих к отторжению трансплантата роговицы. Вышеописанные патологические явления сопряжены с перестройкой клеточных систем в ответ на вирусное воздействие. Недавние открытия в данной области обнаружили значительный вклад трансмембранных и эндосомальных Toll-подобных рецепторов во врожденный противовирусный клеточный ответ. Показано, что эндосомальные Toll-подобные рецепторы 3 типа экспрессируются в кератоцитах только после их фенотипического перехода в фибробласты. Данная трансформация обычно происходит в результате механических и патогенных воздействий на роговицу. Изменение рецепторного состава клеток в ответ на герпесвирусную инвазию вызывает выработку интерферонов 1 типа - интерферона-альфа, интерферона-бета, и синтезу провоспалительных цитокинов, что приводит к вирусной деконтаминации.

This review describes pathophysiological mechanisms of herpes virus infection in cornea cells. It has been previously reported that herpes simplex virus type 1 (HSV-1) infects most of the world’s population. In developing countries, HSV-1 is the leading infectious cause of corneal damage. Also, herpes simplex virus type 1 was assigned the role of one of the factors leading to rejection of the corneal transplant. These pathological phenomena are associated with restructuring of cellular systems in response to viral exposure. Recent discoveries have revealed a significant contribution of transmembrane and endosomal Toll-like receptors to the innate antiviral cell response. It is well known that endosomal Toll-like receptors-3 are expressed in keratocytes only after their phenotypic transformation to fibroblasts. This transformation usually occurs as a result of mechanical or infectious impact on the cornea. Changes in the receptor composition of cells as a response to herpes virus invasion is the main cause of type 1 interferons (interferon-alpha and interferon-beta) production and expression of proinflammatory cytokines, which leads to viral decontamination.
Intraluminal stone in a PD catheter : third world case
Authors: Champtiaux Dechamp Béatrice , Mandart Lise , Durand Pierre-Yves
Published: November 2020

Only 2 cases of intraluminal peritoneal catheter lithiasis have been reported so far. A woman (68 years of age) on CAPD was admitted to hospital because of intermittent outflow obstruction of her peritoneal catheter. A stone was found in the catheter lumen. Its biochemical composition was the same as that of the 2 other cases previously described: calcium-hydroxycardonate-phosphate with an admixture of protein. The stone could not migrate through the intraperitoneal tip hole of the catheter because its size (3 x 4 mm) was greater than the catheter lumen (2.7 mm). That suggests in situ development, directly in the catheter lumen despite inflow-outflow dialysate daily regular rinsings. In the 3 cases, dialysate contained lactate and 1.75 mmol/L calcium.
Lercanidipin chylous peritonitis
Authors: Gaied Hanene , Joseph Maan
Published: November 2020

We report a case of lercanidipin-induced chylous peritonitis (CP) occurring in a patient undergoing continuous ambulatory peritoneal dialysis (CAPD), a 22-year-old male with chronic renal failure with indeterminate nephropathy.. The patient presented a turbid drainage fluid at the start of peritoneal dialysis (PD). The chyloperitoneum resolved after stopping lercanidipin without recurrence.Lercanidipin induced-chyloperitoneum is a rare complication in PD. It is a benign form of non-infectious peritonitis that can be confused with an infectious peritonitis. The most common causes of CP are infectious, obstructive and abdominal malignancy.This paper discusses the possible causes of CP, the physiopathology and the management of lercanidipin-induced chyloperitoneum.
Home hemodialysis : is there still room for high dialysis solution flow rate ?
Authors: Petitclerc Thierry
Published: November 2020

Abstract

The availability in France, for the last decade, of low dialysate flow rate hemodialysis monitors, specifically adapted for daily hemodialysis (5 to 6 sessions per week), is contemporary with a real renewal of home hemodialysis. The clinical benefits of daily hemodialysis with high dialysate flow and of thrice-weekly long nocturnal hemodialysis, which are two intensive hemodialysis modalities, have been demonstrated ; however they are less well demonstrated with low dialysate flow hemodialysis. Thus, some patients may still wish to use conventional hemodialysis monitors in order to limit the number of sessions (and therefore the number of vascular punctures) to 3 per week (or every other day) or wish to benefit from a modality of intensive hemodialysis.
Clinical implications of the implementation of a new automated peritoneal dialysis remote patient management system with cloud-based
Authors: Jotterand-Drepper Valérie
Published: November 2020

In the last decades, remote patient management (RPM) has been of growing interest in medical fields. In this article we describe the clinical implications of the implementation of a newly available automated peritoneal dialysis (APD) RPM system with cloud-based connectivity. This system provides data sent from the cycler about the course of the peritoneal dialysis (PD) therapy, offering the medical team the opportunity to analyse them on an everyday basis and subsequently remotely alter PD prescription.The main advantages discussed here are sparing of long or difficult travels, especially for patients with social, geographical or physical limitations, early identification and management of occurring issues such as catheter dysfunction or non-adherence to prescribed PD therapy, a potential clue to an imminent peritonitis, and finally a more personalized APD prescription. Further impacts of the implementation of RPM in peritoneal dialysis on patients outcomes, health costs and its potential influence on a greater take-on rate of the technique have still to be evaluated
Case report about three patients affected by autosomal dominant polycystic kidney disease who started peritoneal dialysis after nephrectomy and simultaneous peritoneal catheter implantation.
Authors: Lelandais Lise , Roubiou Caroline , Courivaud Cécile , Guichard Guilllaume , Barkatz Johann , Bressson-Vautrin Catherine
Published: November 2020

Peritoneal dialysis (PD) initiation can be difficult in patients developing end stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (ADPKD) when these patients need nephrectomy to prepare kidney transplantation. Here we describe the cases of 3 adult patients followed in the nephrology ward of Besançon in 2017 and 2018 for ESRD due to ADPKD and who began peritoneal dialysis in the post-operative period following nephrectomy with simultaneous peritoneal catheter implantation. The data were collected retrospectively.Among the three patients included, all began PD during the first month after being operated on, without requiring hemodialysis. Mean delay between nephrectomy and PD start was 8.7 days. The renal-replacement therapy was begun following a continuous ambulatory PD (CAPD) technique with small volumes (1.5L), then was carried on with automated PD (APD) technique with small volumes. The mean delay between nephrectomy and the establishment of a standard APD program was 24.3 days. No major complications were reported at the establishment of PD, particularly there were no dialysate leaks. On a long term view, technical survival was good since 2 patients are still treated by PD whereas one patient has been transplanted. Adequacy criteria were satisfactory. To conclude, our group of 3 patients shows very interesting results about PD start in the post-operative period after nephrectomy with simultaneous PD catheter implantation in polycystic patients.
Management of fungal peritonitis : a Moroccan single peritoneal dialysis unit experience
Authors: Hadja Kone Moussokoro , Bouattar Tarik , Fares Ibtissam , Benbella Meryem , Ouzeddoun Naima , Bayahia Rabia , Benamar Loubna
Published: November 2020

Introduction: Fungal peritonitis (PF) in peritoneal dialysis (PD) is a serious infection that involves the functional prognosis of the peritoneum and the patient's vital prognosis. It must benefit from a fast handling but nevertheless not very codified. Each center therefore ensures an individual care of its patients.

Materiel and method: The purpose of our study is to describe our 10-year experience through our patients who presented FP. We performed a descriptive retrospective study of FP cases documented in the PD unit.

Results: the prevalence of FP was 5,1%, which represent 9 cases. Predominant clinical signs were dialysat turbidity and abdominal pain. FP was primitive for 3 patients. The antifungal therapy used was Fluconazole, which was combined with an increased number of peritoneal exchanges. DP catheter ablation was done for 8 patients with an average delay of 5.5 days. The overall outcome was favorable and 3 patients continued PD. No death or encapsulating peritonitis was a consequence of FP.

Discussion and conclusion: FP is an infectious complication in PD. Its’ death rate is elevated; dropping-out of PD rate too is elevated. The favorable evolution of our patients that stayed in PD let us think that it may be possible to maintain more patients in PD after FP.
Revue de presse des jeunes néphrologues : 2e trimestre 2019 de la Dialyse à Domicile
Authors: Seret Guillaume , Vrigneaud Laurence , Bataille Stanislas , Carceles Odette , Gosselin Morgane , Lanot Antoine , Lavainne Frédéric , Morinière Beaume Julie , Nodimar Céline
Published: November 2020

Un groupe de néphrologues issus du Club des jeunes Néphrologues sélectionne chaque mois à tour de rôle un article de la littérature internationale en rapport avec la dialyse à domicile, Dialyse Péritonéale ou Hémodialyse à Domicile, et en propose un résumé en français et son analyse. Ces résumés sont librement téléchargeables sur le site du RDPLF à l’adresse : https://www.rdplf.org/biblio.html. Depuis décembre 2018 ceux sélectionnés au cours du trimestre par ces néphrologues sont publiés sous leur nom dans la présente rubrique du Bulletin de la Dialyse à Domicile.
Editorial
Authors: Verger Christian , Dratwa Max
Published: November 2020

Le Bulletin de la Dialyse à Domicile (BDD) existe depuis un an et 3 mois (premier numéro en juin 2018).  Le nombre de téléchargements des articles, entre 150 et 300 fois, souligne son succès d’emblée auprès des infirmières comme des néphrologues. Nous remercions tous les auteurs qui ont soumis un article ainsi que nos relecteurs qui ont assuré une relecture critique en double aveugle.  Tous nos relecteurs sont externes au comité éditorial, réputés pour leurs compétences, et provenant jusqu’à présent de France, Belgique, Canada, et Argentine. Le site Web de la revue a été complété, ainsi que le processus éditorial afin d’être en accord avec les recommandations internationales de bonnes pratiques pour la publication de journaux scientifiques en Libre Accès. Nous travaillons pour obtenir une indexation prochaine.

Dans ce numéro, nous inaugurons un nouveau mode de publication :  les articles sont, pour la plupart, publiés en deux langues, Français et Anglais (la version anglaise est à la fin de la version française dans les fichiers pdf téléchargeables). Cela permet de recevoir des articles dans les deux langues et de rendre leur contenu accessible à la fois aux communautés francophone et anglophone. Nous espérons ainsi créer un pont entre les équipes infirmières et néphrologues de ces deux communautés, renforçant le dialogue entre cultures et augmentant la diffusion des travaux soumis

Dr Christian Verger, Prof Max Dratwa, directeurs du Bulletin de la Dialyse à Domicile.
Calciphylaxis: A successful outcome whilst on peritoneal dialysis
Authors: Gaspar Ana , Falcão Luis , Correia Sofia , Carvalho Maria João , Rodrigues Anabela , Cabrita Antonio
Published: November 2020

Calciphylaxis is a life threatening disease for which patients with chronic kidney disease, particular those on dialysis, are at increased risk. As it is a rare condition, treatment options are limited and duration of treatment is not clear, especially when it comes to patients on renal replacement treatment with peritoneal dialysis.

We report a case of a 55 year-old woman with end stage renal disease on renal replacement treatment with peritoneal dialysis for five months that presented with severe calciphylaxis of both legs. She had started haemodialysis at the age of 31 and 3 later she received a cadaveric renal transplant that lasted for 20 years. She was treated with warfarin due to atrial fibrillation diagnosis. The treatment approach was multimodal and multidisciplinary and included treatment with sodium thiosulfate and hyperbaric oxygen, warfarin suspension and maintenance of optimized peritoneal dialysis prescription. Additionally, wound dressings were done every other day and antibiotics started whenever there were signs of infection and pain was managed with high doses of opiates and pain adjuvants. There was significant improvement and the patient kept peritoneal dialysis treatment with preserved residual renal function. This raises the question, if there is a need to transition calciphylaxis patients on peritoneal dialysis to haemodialysis, as it is possible to ensure a high efficiency dialysis program with automated peritoneal dialysis.
Initiation au Logiciel de statistiques R : réalisez vos premières visualisations avec le package ggplot2
Authors: Della Vedova Claire
Published: November 2020

NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.

Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .

Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Ce troisième article est consacré au package ggplot2 et nécessite un effort d’apprentissage, mais il permet la réalisation de nombreux types de visualisations, avec des rendus qui peuvent être de très haute qualité, et ainsi directement utilisables dans des publications.

Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.

Claire Della Vedova est Ingénieure en biostatistique / data analyste, Elle utilise quotidiennement le logiciel R pour analyser des données. Elle a travaillé pendant plus de 15 ans dans les domaines de l’environnement et de la santé, et a formé de nombreux étudiants et chercheurs à l’utilisation de R. Elle anime depuis novembre 2017 le blog Statistique et Logiciel R dont le but est d’aider les débutants à mieux appréhender les méthodes statistiques classiques et à utiliser le logiciel R plus efficacement, notamment au travers de tutoriels : https://statistique-et-logiciel-r.com/.
First viral replication of Covid-19 identified in the peritoneal dialysis fluid of a symptomatic patient
Authors: Nouvier Mathilde , Chalençon Elodie , Novel-Catin Etienne , Pelletier Solenne , Hallonet Patrick , Charre Caroline , Koppe Laetitia , Fouque Denis
Published: November 2020

RETRACTED : the authors retracted see : https://bdd.rdplf.org/index.php/bdd/article/view/54713

The COVID-19 pandemic is characterized by a disease with mainly respiratory tropism and varying severity.

Viral excretion of COVID-19 has been described in both urine and stool  with the risk of contamination by stool. No viral replication in the peritoneal dialysis fluid has been reported to date.

We report an observation demonstrating the presence of the virus in the peritoneal dialysis drainage fluid of a COVID-19 patient. This underlines the importance in COVID-19 patients of considering dialysis fluid as a possible source of contamination.
Covid-19 epidemic in the dialysis units of the french speaking part of Belgium : special insight into patients on home dialysis
Authors: Collart Fredéric , Des Grottes Jean-Marin , Baudoux Thomas , Cuvelier Charles , Debelle Frederic , Goffin Eric , Masset Catherine , Mat Olivier , Cornet Georges
Published: November 2020

In the French-speaking part of Belgium, between march and end of may 2020, 284 patients have suffered a Covid-19 infection, 7,9% of the prevalent dialysis population. Some of them have been  diagnosed through rt-PCT as they were symptomatic, others, asymptomatic,  being diagnosed by swab viral culture. Fifty two patients died (18% of the positive patients). The vast majority of them were patients on hemodialysis, only ten cases have been observed in patients on home dialysis techniques. Primary renal disease were diabetes or renal hypertensive disease in more than 50% of the patients and the most important comorbidities were cardiac ischemic or congestive disease, autonomy problems, cancer and smoking habits.
Transition between peritoneal dialysis and home hemodialysis in Belgium and France in the RDPLF
Authors: Verger Christian , Fabre Emmanuel
Published: November 2020

A renewed interest in home hemodialysis has emerged in recent years, favored by the availability of new dialysis machines and encouraging publication about  daily hemodialysis. Since 2013, the RDPLF has become a home dialysis registry that records the data of patients treated with peritoneal dialysis and those treated with home hemodialysis, all techniques combined. Nine Belgian centers and fifty seven French centers communicate information about their patients treated by hemodialysis at home. In the RDPLF centers, 56% of Belgian home hemodialysis patients are treated with daily hemodialysis, in France 83% of home patients are on daily dialysis. This French difference however is not representative of the whole country but can be explained through recruitment of new centers already involved in peritoneal dialysis and convinced by the interest of continuaous daily treatment. In both countries, 13% of home hemodialysis patients have been previously treated with peritoneal dialysis with an interim period of in-center hemodialysis or transplantation. The median duration of in center hemodialysis is 10 months with extremes ranging from 2 months to 25 years. PD patients treated secondarily in home hemodialysis are mainly young, non-diabetic and independent patients. Early information in patients who have a risk of peritoneal dialysis failure, and the provision of materials allowing both techniques would reduce or abolish a transient transfer to in center hemodialysis  and would ensure home care in patients who prefer.
Theoretical Study of Stability, Structure, and Optical Spectra of Ultra-Small Silver Clusters Using Density Functional Theory
Authors: Farshad Mohsen , Perera Duwage , Rasaiah jayendran
Published: November 2020

Our article is a systematic study toward understanding the mechanism of silver cluster formation. We calculated optical spectra of ultra-small silver clusters using time-dependent density functional theory (TDDFT) and compared our results with time-resolved UV-Vis spectra obtained from pulse radiolysis experiments during early stages of cluster formation. This comparative study indicates that the formation mechanism of silver clusters occurs through both monomer and ion addition growth pathways. Also, we calculated free energy of formation of small cationic and neutral clusters using density functional theory (DFT) which shows the thermodynamic stability of cationic clusters. In a conventional experimental system with the common reducing agents, the formation of cationic clusters is kinetically favored owing to the dominance of charged ions relative to neutral atoms in the system. While we show the stability of small cationic clusters relative to neutral clusters, collectively, we deduce that the monomer addition along with ion addition growth pathway is involved in silver cluster formation mechanism. We further show the effect of solvent and water ligands on structure, stability, and optical properties of small clusters.
Completion of Partial Reaction Equations
Authors: Vaucher Alain C. , Schwaller Philippe , Laino Teodoro
Published: November 2020

We present a deep-learning model for inferring missing molecules in reaction equations. Such an algorithm features multiple interesting behaviors. First, it can infer the necessary reagents and solvents in chemical transformations specified only in terms of main compounds, as often resulting from retrosynthetic analyses. The completion with necessary reagents ensures that reaction equations are compatible with deep-learning models relying on a complete reaction specification. Second, it can cure existing datasets by detecting missing compounds, such as reagents that are essential for given classes of reactions. Finally, this model is a generalization of models for forward reaction prediction and retrosynthetic analysis, as both can be formulated in terms of incomplete reaction equations. We illustrate that a single trained model, based on the transformer architecture and acting on reaction SMILES strings, can address all three points.

Workshop paper at the Machine Learning for Molecules Workshop at NeurIPS 2020.
The prevalence of autoimmune endocrine diseases in vitiligo patients
Authors: Troshina E. A. , Volnukhin V. A. , Petrov V. A. , Nuralieva N. F. , Yukina M. Yu. , Orlova E. M. , Frigo N. V.
Published: November 2020

Vitiligo is a common polygenic autoimmune disease in which the foci of depigmentation are formed on the skin and/or mucous membranes as a result of the death of melanocytes. There are several hypotheses for the pathogenesis of the disease, the leading role among them is played the autoimmune hypothesis. This review summarizes the available literature data on the prevalence and structure of comorbid endocrine autoimmune pathology in vitiligo patients. In most studies conducted in Europe, America and Asia the prevalence of autoimmune thyroid diseases (including autoimmune thyroiditis and Graves disease), diabetes mellitus and autoimmune adrenal insufficiency was higher in vitiligo patients than in the general population. The results of some studies indicate a frequent association of vitiligo with autoimmune polyglandular syndromes. In the structure of comorbid pathology the highest prevalence was in autoimmune thyroid diseases. A number of studies have established a higher prevalence of autoimmune endocrine diseases in women, as well as in nonsegmental vitiligo patients and in cases of family history of vitiligo and/or other autoimmune diseases. In addition, it was shown that the prevalence of endocrine diseases increases with increasing area of depigmentation. The data obtained justify the advisability of conducting a timely examination of vitiligo patients with the aim of early detection of comorbid diseases and the appointment of appropriate treatment. Further studies are needed to investigate the effect of the identified associations on the course of vitiligo and comorbid endocrinopathies, as well as the effectiveness of therapy and the quality of life of patients.
The prevalence of newly diagnosed autoimmune diseases among patients with Graves’ disease and autoimmune polyglandular syndrome of adults
Authors: Troshina E. A. , Larina A. A. , Sheremeta M. S. , Malisheva N. M.
Published: November 2020

Gravess disease is a common part of Autoimmune polyglandular syndrome (APS) and among thyroid autoimmune disorders is usually preceded the onset of the syndrome.
Aim.The aim of this study was to determine the frequency of occurrence of APS type 2, 3 among patients with Graves disease.
Materials and methods.Sera of 94 patients with Gravess disease, 116 patients with APS 24 types and 80 healthy subjects were screened for 21-OH Ab, insulin-Ab (IAA), Islet Cell-Ab (ICA), glutamic acid decarboxylase-Ab (GADA), protein tyrosine phosphatase-Ab (IA2), Zinc Transporter 8-Ab (ZnT8), Anti-gliadin-Ab (IgA+IgG) (AGA), Anti-transglutaminase-Ab (IgA+IgG) (Anti-tTG), Anti-parietal cell-Ab (APCA), Intrinsic Factor-Ab (IF), Rheumatoid factor (RF), Anti Ovarian Antibodies (AOA). Serum cortisol, fasting plasma glucose levels were measured.
Results.The presence of Addisons disease and the onset of Type 1 DM was not determined among Graves disease patients. None of the patients with Graves disease and in the healthy control group had 21-OH-antibodies detected. The frequency of 21-OH-Ab was 4.2% in APS type 3 (p=0.07) and 91.6% in APS type 2, 4 (p0.001). The prevalence of diabetes-associated autoantibodies was 20.2% among Gravess disease patients against 8.75% in healthy subjects control group (p0.05); OR 2.64; 95% CI 1.056.66 and 30.2% in APS of adults (DM 1 negative group) (p=0.18). The prevalence of APCA-markers of autoimmune gastritis was 31.9% in Gravess disease, 48.3% in APS 24 types (p=0.01); OR 1.99; 95% CI 1.183.51, and 12.5% in control group (p0.01); OR 3.28; 95% CI 1.497.24. There were no significant differences in the frequency of occurrence of IF-Ab and RF-Ab in the groups. The frequency of AGA and ATA was 28.7% in Graves disease, 36.2% in APS types 24 (p=0.3), 10% in the control group ((р0.01); OR 3.63; 95% CI 1.548.54. Graves disease patients with risk of developing APS type 3 (positive diabetes-associated and other autoantibodies) had relatives with autoimmune diseases in 57.5% of cases (p=0.05); OR 2.18; 95% CI 1.034.63.
Conclusion.Graves disease patients are at high risk for future development of APS 3 type, especially those with inheritance for autoimmune diseases. Screening for the immunological markers, pathognomonic for coexisting autoimmune diseases in such patients with Graves disease, as well as in patients with APS type 3, should be done regularly.
Obesity without diabetes: the role of hormonal regulation
Authors: Shestakova E. A. , Sklyanik I. A. , Panevina A. S. , Nikankina L. V. , Shestakova M. V. , Dedov I. I.
Published: November 2020

Aim.Obese patients without diabetes present an interesting phenotype to explore protective mechanisms against type 2 diabetes (T2D) development. In our study we looked for specific hormonal features of obese patients without T2D.
Materials and methods.We included 6 groups of patients with different metabolic profiles (n=212): controls with BMI25 kg/m2, HbA1c6%, age 30 years; patients with 25BMI30 kg/m2and HbA1c6%; patients with 25BMI30 kg/m2and HbA1c6%; patients with BMI30 kg/m2and HbA1c6% (+ Obesity - T2D) obese patients without T2D or prediabetes; patients with BMI30 kg/m2and newly-diagnosed T2D/prediabetes, HbA1c6%; patients with known history of T2D on glucose-lowering drugs with BMI30 kg/m2. Insulin, GLP-1, GIP were measured during glucose-tolerance test at 0, 30 and 120 minutes; insulin resistance (IR) was assessed by HOMA-IR.
Results.Waist circumference was bigger in patients with obesity despite their metabolic profile comparing to patients without obesity (p0.001). Waist-to-hip ratio was similar in patients with different metabolic status. According to IR + Obesity - T2D group had intermediate position: IR was higher in that group comparing to people without obesity, but was less that in patients with obesity and HbA1c6% (p0.001). + Obesity - T2D group had the most potent baseline insulin secretion, assessed by НОМА-%band the highest postprandial secretion, measured by insulinogenic index among all patient groups with obesity (p0.001). There was no significant difference in GLP-1 secretion; GIP secretion was higher in patients with BMI30 kg/m2comparing to people with BMI30 kg/m2(p0.01).