bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Tables 1 through 11 from Discovery and Optimization of HKT288, a Cadherin-6–Targeting ADC for the Treatment of Ovarian and Renal Cancers
Authors: Bialucha Carl U. , Collins Scott D. , Li Xiao , Saxena Parmita , Zhang Xiamei , Dürr Clemens , Lafont Bruno , Prieur Pierric , Shim Yeonju , Mosher Rebecca , Lee David , Ostrom Lance , Hu Tiancen , Bilic Sanela , Rajlic Ivana Liric , Capka Vladimir , Jiang Wei , Wagner Joel P. , Elliott GiNell , Veloso Artur , Piel Jessica C. , Flaherty Meghan M. , Mansfield Keith G. , Meseck Emily K. , Rubic-Schneider Tina , London Anne Serdakowski , Tschantz William R. , Kurz Markus , Nguyen Duc , Bourret Aaron , Meyer Matthew J. , Faris Jason E. , Janatpour Mary J. , Chan Vivien W. , Yoder Nicholas C. , Catcott Kalli C. , McShea Molly A. , Sun Xiuxia , Gao Hui , Williams Juliet , Hofmann Francesco , Engelman Jeffrey A. , Ettenberg Seth A. , Sellers William R. , Lees Emma
Published: April 2023

This file contains supplementary tables describing parameters for antitumor activity (T/C analyses), PK and protein crystallography.
Table S1 and S2 from SHP2 Inhibition Prevents Adaptive Resistance to MEK Inhibitors in Multiple Cancer Models
Authors: Fedele Carmine , Ran Hao , Diskin Brian , Wei Wei , Jen Jayu , Geer Mitchell J. , Araki Kiyomi , Ozerdem Ugur , Simeone Diane M. , Miller George , Neel Benjamin G. , Tang Kwan Ho
Published: April 2023

Table S1: Bliss Index for Effect of MEK-I/SHP099 Combination on Cancer Cell Proliferation Table S2: Primer Sequences for qRT-PCR
Supplementary Figure S2 from Maturation Stage of T-cell Acute Lymphoblastic Leukemia Determines BCL-2 versus BCL-XL Dependence and Sensitivity to ABT-199
Authors: Chonghaile Triona Ni , Roderick Justine E. , Glenfield Cian , Ryan Jeremy , Sallan Stephen E. , Silverman Lewis B. , Loh Mignon L. , Hunger Stephen P. , Wood Brent , DeAngelo Daniel J. , Stone Richard , Harris Marian , Gutierrez Alejandro , Kelliher Michelle A. , Letai Anthony
Published: April 2023

The percentage of cells expressing CD8 is shown for both ETP-ALL and for Typical T-ALL primary human samples. The data is modified from the published online dataset (2). The majority of typical T-ALL samples are positive for CD8 expression by flow cytometry analysis.
Figure S1-9; Supplementary methods from VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma
Authors: Yao Xiaosai , Tan Jing , Lim Kevin Junliang , Koh Joanna , Ooi Wen Fong , Li Zhimei , Huang Dachuan , Xing Manjie , Chan Yang Sun , Qu James Zhengzhong , Tay Su Ting , Wijaya Giovani , Lam Yue Ning , Hong Jing Han , Lee-Lim Ai Ping , Guan Peiyong , Ng Michelle Shu Wen , He Cassandra Zhengxuan , Lin Joyce Suling , Nandi Tannistha , Qamra Aditi , Xu Chang , Myint Swe Swe , Davies James O. J. , Goh Jian Yuan , Loh Gary , Tan Bryan C. , Rozen Steven G. , Yu Qiang , Tan Iain Bee Huat , Cheng Christopher Wai Sam , Li Shang , Chang Kenneth Tou En , Tan Puay Hoon , Silver David Lawrence , Lezhava Alexander , Steger Gertrud , Hughes Jim R. , Teh Bin Tean , Tan Patrick
Published: April 2023

Supplementary methods. Supplementary Figures 1-9
Supplemental Figure Legends from Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells
Authors: Shum Thomas , Omer Bilal , Tashiro Haruko , Kruse Robert L. , Wagner Dimitrios L. , Parikh Kathan , Yi Zhongzhen , Sauer Tim , Liu Daofeng , Parihar Robin , Castillo Paul , Liu Hao , Brenner Malcolm K. , Metelitsa Leonid S. , Gottschalk Stephen , Rooney Cliona M.
Published: April 2023

Figure legends for Supplemental Figures 1-6 and Supplemental Table 1
Supplementary Table S8 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Authors: Valls Ester , Lobry Camille , Geng Huimin , Wang Ling , Cardenas Mariano , Rivas Martín , Cerchietti Leandro , Oh Philmo , Yang Shao Ning , Oswald Erin , Graham Camille W. , Jiang Yanwen , Hatzi Katerina , Agirre Xabier , Perkey Eric , Li Zhuoning , Tam Wayne , Bhatt Kamala , Leonard John P. , Zweidler-McKay Patrick A. , Maillard Ivan , Elemento Olivier , Ci Weimin , Aifantis Iannis , Melnick Ari
Published: April 2023

Supplementary Table S8. DLBCL p-values and rho values on GCB-DLBCL probesets for Notch2 pathway genes. (See Supplementary Figure S1G).
Supplementary Table S6 from BCL6 Antagonizes NOTCH2 to Maintain Survival of Human Follicular Lymphoma Cells
Authors: Valls Ester , Lobry Camille , Geng Huimin , Wang Ling , Cardenas Mariano , Rivas Martín , Cerchietti Leandro , Oh Philmo , Yang Shao Ning , Oswald Erin , Graham Camille W. , Jiang Yanwen , Hatzi Katerina , Agirre Xabier , Perkey Eric , Li Zhuoning , Tam Wayne , Bhatt Kamala , Leonard John P. , Zweidler-McKay Patrick A. , Maillard Ivan , Elemento Olivier , Ci Weimin , Aifantis Iannis , Melnick Ari
Published: April 2023

Supplementary Table S6. DLBCL p-values on DLBCL signatures. (See Supplementary Figure S1E).
Supplementary Table 3 from Prediction of DNA Repair Inhibitor Response in Short-Term Patient-Derived Ovarian Cancer Organoids
Authors: Hill Sarah J. , Decker Brennan , Roberts Emma A. , Horowitz Neil S. , Muto Michael G. , Worley Michael J. , Feltmate Colleen M. , Nucci Marisa R. , Swisher Elizabeth M. , Nguyen Huy , Yang Chunyu , Morizane Ryuji , Kochupurakkal Bose S. , Do Khanh T. , Konstantinopoulos Panagiotis A. , Liu Joyce F. , Bonventre Joseph V. , Matulonis Ursula A. , Shapiro Geoffrey I. , Berkowitz Ross S. , Crum Christopher P. , D'Andrea Alan D.
Published: April 2023

Supplementary Table 3
Supplementary Tables S1-S10 from EGFR and MET Amplifications Determine Response to HER2 Inhibition in ERBB2-Amplified Esophagogastric Cancer
Authors: Sanchez-Vega Francisco , Hechtman Jaclyn F. , Castel Pau , Ku Geoffrey Y. , Tuvy Yaelle , Won Helen , Fong Christopher J. , Bouvier Nancy , Nanjangud Gouri J. , Soong Joanne , Vakiani Efsevia , Schattner Mark , Kelsen David P. , Lefkowitz Robert A. , Brown Karen , Lacouture Mario E. , Capanu Marinela , Mattar Marissa , Qeriqi Besnik , Cecchi Fabiola , Tian Yuan , Hembrough Todd , Nagy Rebecca J. , Lanman Richard B. , Larson Steven M. , Pandit-Taskar Neeta , Schöder Heiko , Iacobuzio-Donahue Christine A. , Ilson David H. , Weber Wolfgang A. , Berger Michael F. , de Stanchina Elisa , Taylor Barry S. , Lewis Jason S. , Solit David B. , Carrasquillo Jorge A. , Scaltriti Maurizio , Schultz Nikolaus , Janjigian Yelena Y.
Published: April 2023

Supplementary Tables S1-S10
Figures S11-S12 from Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer
Authors: Puyang Xiaoling , Furman Craig , Zheng Guo Zhu , Wu Zhenhua J. , Banka Deepti , Aithal Kiran , Agoulnik Sergei , Bolduc David M. , Buonamici Silvia , Caleb Benjamin , Das Subhasree , Eckley Sean , Fekkes Peter , Hao Ming-Hong , Hart Andrew , Houtman René , Irwin Sean , Joshi Jaya J. , Karr Craig , Kim Amy , Kumar Namita , Kumar Pavan , Kuznetsov Galina , Lai Weidong G. , Larsen Nicholas , Mackenzie Crystal , Martin Lesley-Ann , Melchers Diana , Moriarty Alyssa , Nguyen Tuong-Vi , Norris John , O'Shea Morgan , Pancholi Sunil , Prajapati Sudeep , Rajagopalan Sujatha , Reynolds Dominic J. , Rimkunas Victoria , Rioux Nathalie , Ribas Ricardo , Siu Amy , Sivakumar Sasirekha , Subramanian Vanitha , Thomas Michael , Vaillancourt Frédéric H. , Wang John , Wardell Suzanne , Wick Michael J. , Yao Shihua , Yu Lihua , Warmuth Markus , Smith Peter G. , Zhu Ping , Korpal Manav
Published: April 2023

H3B-5942 suppresses co-activator recruitment and shows potency in endocrine sensitive and resistant lines
Supplementary Table 1, Figures 1-9, Methods from Suppression of Tumor Invasion and Metastasis by Concurrent Inhibition of c-Met and VEGF Signaling in Pancreatic Neuroendocrine Tumors
Authors: Sennino Barbara , Ishiguro-Oonuma Toshina , Wei Ying , Naylor Ryan M. , Williamson Casey W. , Bhagwandin Vikash , Tabruyn Sebastien P. , You Weon-Kyoo , Chapman Harold A. , Christensen James G. , Aftab Dana T. , McDonald Donald M.
Published: April 2023

PDF file - 2MB
Table S4 from Organoid Profiling Identifies Common Responders to Chemotherapy in Pancreatic Cancer
Authors: Tiriac Hervé , Belleau Pascal , Engle Dannielle D. , Plenker Dennis , Deschênes Astrid , Somerville Tim D. D. , Froeling Fieke E. M. , Burkhart Richard A. , Denroche Robert E. , Jang Gun-Ho , Miyabayashi Koji , Young C. Megan , Patel Hardik , Ma Michelle , LaComb Joseph F. , Palmaira Randze Lerie D. , Javed Ammar A. , Huynh Jasmine C. , Johnson Molly , Arora Kanika , Robine Nicolas , Shah Minita , Sanghvi Rashesh , Goetz Austin B. , Lowder Cinthya Y. , Martello Laura , Driehuis Else , LeComte Nicolas , Askan Gokce , Iacobuzio-Donahue Christine A. , Clevers Hans , Wood Laura D. , Hruban Ralph H. , Thompson Elizabeth , Aguirre Andrew J. , Wolpin Brian M. , Sasson Aaron , Kim Joseph , Wu Maoxin , Bucobo Juan Carlos , Allen Peter , Sejpal Divyesh V. , Nealon William , Sullivan James D. , Winter Jordan M. , Gimotty Phyllis A. , Grem Jean L. , DiMaio Dominick J. , Buscaglia Jonathan M. , Grandgenett Paul M. , Brody Jonathan R. , Hollingsworth Michael A. , O'Kane Grainne M. , Notta Faiyaz , Kim Edward , Crawford James M. , Devoe Craig , Ocean Allyson , Wolfgang Christopher L. , Yu Kenneth H. , Li Ellen , Vakoc Christopher R. , Hubert Benjamin , Fischer Sandra E. , Wilson Julie M. , Moffitt Richard , Knox Jennifer , Krasnitz Alexander , Gallinger Steven , Tuveson David A.
Published: April 2023

Table S4
Supplementary Figure Legends from Remodeling of the Collagen Matrix in Aging Skin Promotes Melanoma Metastasis and Affects Immune Cell Motility
Authors: Kaur Amanpreet , Ecker Brett L. , Douglass Stephen M. , Kugel Curtis H. , Webster Marie R. , Almeida Filipe V. , Somasundaram Rajasekharan , Hayden James , Ban Ehsan , Ahmadzadeh Hossein , Franco-Barraza Janusz , Shah Neelima , Mellis Ian A. , Keeney Frederick , Kossenkov Andrew , Tang Hsin-Yao , Yin Xiangfan , Liu Qin , Xu Xiaowei , Fane Mitchell , Brafford Patricia , Herlyn Meenhard , Speicher David W. , Wargo Jennifer A. , Tetzlaff Michael T. , Haydu Lauren E. , Raj Arjun , Shenoy Vivek , Cukierman Edna , Weeraratna Ashani T.
Published: April 2023

Supplementary Figure Legends
Supplementary Table 12 from Posttranslational Regulation of the Exon Skipping Machinery Controls Aberrant Splicing in Leukemia
Authors: Zhou Yalu , Han Cuijuan , Wang Eric , Lorch Adam H. , Serafin Valentina , Cho Byoung-Kyu , Gutierrez Diaz Blanca T. , Calvo Julien , Fang Celestia , Khodadadi-Jamayran Alireza , Tabaglio Tommaso , Marier Christian , Kuchmiy Anna , Sun Limin , Yacu George , Filip Szymon K. , Jin Qi , Takahashi Yoh-Hei , Amici David R. , Rendleman Emily J. , Rawat Radhika , Bresolin Silvia , Paganin Maddalena , Zhang Cheng , Li Hu , Kandela Irawati , Politanska Yuliya , Abdala-Valencia Hiam , Mendillo Marc L. , Zhu Ping , Palhais Bruno , Van Vlierberghe Pieter , Taghon Tom , Aifantis Iannis , Goo Young Ah , Guccione Ernesto , Heguy Adriana , Tsirigos Aristotelis , Wee Keng Boon , Mishra Rama K. , Pflumio Francoise , Accordi Benedetta , Basso Giuseppe , Ntziachristos Panagiotis
Published: April 2023

Protein List and Enrichment Analysis of KGG-MS
Data from Senescence Rewires Microenvironment Sensing to Facilitate Antitumor Immunity
Authors: Chen Hsuan-An , Ho Yu-Jui , Mezzadra Riccardo , Adrover Jose M. , Smolkin Ryan , Zhu Changyu , Woess Katharina , Bernstein Nicholas , Schmitt Georgia , Fong Linda , Luan Wei , Wuest Alexandra , Tian Sha , Li Xiang , Broderick Caroline , Hendrickson Ronald C. , Egeblad Mikala , Chen Zhenghao , Alonso-Curbelo Direna , Lowe Scott W.
Published: April 2023

Abstract
Cellular senescence involves a stable cell-cycle arrest coupled to a secretory program that, in some instances, stimulates the immune clearance of senescent cells. Using an immune-competent liver cancer model in which senescence triggers CD8 T cell–mediated tumor rejection, we show that senescence also remodels the cell-surface proteome to alter how tumor cells sense environmental factors, as exemplified by type II interferon (IFNγ). Compared with proliferating cells, senescent cells upregulate the IFNγ receptor, become hypersensitized to microenvironmental IFNγ, and more robustly induce the antigen-presenting machinery—effects also recapitulated in human tumor cells undergoing therapy-induced senescence. Disruption of IFNγ sensing in senescent cells blunts their immune-mediated clearance without disabling the senescence state or its characteristic secretory program. Our results demonstrate that senescent cells have an enhanced ability to both send and receive environmental signals and imply that each process is required for their effective immune surveillance.
Significance:
Our work uncovers an interplay between tissue remodeling and tissue-sensing programs that can be engaged by senescence in advanced cancers to render tumor cells more visible to the adaptive immune system. This new facet of senescence establishes reciprocal heterotypic signaling interactions that can be induced therapeutically to enhance antitumor immunity.

See the interview with Direna Alonso-Curbelo, PhD, recipient of the inaugural Cancer Discovery Early Career Award: https://vimeo.com/992987447

See related article by Marin et al., p. 410.

This article is highlighted in the In This Issue feature, p. 247
Supplementary Tables 1 - 3, Methods, Figure Legends from c-Abl Modulates Tumor Cell Sensitivity to Antibody-Dependent Cellular Cytotoxicity
Authors: Murray Joseph C. , Aldeghaither Dalal , Wang Shangzi , Nasto Rochelle E. , Jablonski Sandra A. , Tang Yong , Weiner Louis M.
Published: April 2023

Supplementary Table 1. Gene symbol and target sequences for two pooled siRNAs used in primary screens. Supplementary Table 2. Gene symbols and target sequences for four individual siRNAs utilized in secondary screens. Supplementary Table 3. Gene symbols and QuantiTect Primer Assays (Qiagen) used for quantitative reverse-transcription PCR (Q-RT-PCR) assessments.
Supplementary Table S2 from Quantitative Analysis of Immune Infiltrates in Primary Melanoma
Authors: Gartrell Robyn D. , Marks Douglas K. , Hart Thomas D. , Li Gen , Davari Danielle R. , Wu Alan , Blake Zoë , Lu Yan , Askin Kayleigh N. , Monod Anthea , Esancy Camden L. , Stack Edward C. , Jia Dan Tong , Armenta Paul M. , Fu Yichun , Izaki Daisuke , Taback Bret , Rabadan Raul , Kaufman Howard L. , Drake Charles G. , Horst Basil A. , Saenger Yvonne M.
Published: April 2023

Demographics for DSS Cohort.
Table S1 from Lnc-C/EBPβ Negatively Regulates the Suppressive Function of Myeloid-Derived Suppressor Cells
Authors: Gao Yunhuan , Sun Wei , Shang Wencong , Li Yuanyuan , Zhang Dan , Wang Tianze , Zhang Xipeng , Zhang Shiwu , Zhang Yuan , Yang Rongcun
Published: April 2023

Reagents and primers
Supplementary Table from The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
Authors: Paavola Kevin J. , Roda Julie M. , Lin Vicky Y. , Chen Peirong , O'Hollaren Kyle P. , Ventura Richard , Crawley Suzanne C. , Li Betty , Chen Hung-I H. , Malmersjö Seth , Sharkov Nikolai A. , Horner Geoffrey , Guo Wei , Kutach Alan K. , Mondal Kalyani , Zhang Zhen , Lichtman Joshua S. , Song Christina , Rivera Lee B. , Liu Wenhui , Luo Jian , Wang Yan , Solloway Mark J. , Allan Bernard B. , Kekatpure Avantika , Starck Shelley R. , Haldankar Raj , Fan Bin , Chu Chun , Tang Jie , Molgora Martina , Colonna Marco , Kaplan Daniel D. , Hsu Jer-Yuan
Published: April 2023

Supplementary Table from The Fibronectin–ILT3 Interaction Functions as a Stromal Checkpoint that Suppresses Myeloid Cells
Supplementary Table 7 from Overcoming Acquired Epigenetic Resistance to BTK Inhibitors
Authors: Shaffer Arthur L. , Phelan James D. , Wang James Q. , Huang DaWei , Wright George W. , Kasbekar Monica , Choi Jaewoo , Young Ryan M. , Webster Daniel E. , Yang Yandan , Zhao Hong , Yu Xin , Xu Weihong , Roulland Sandrine , Ceribelli Michele , Zhang Xiaohu , Wilson Kelli M. , Chen Lu , McKnight Crystal , Klumpp-Thomas Carleen , Thomas Craig J. , Häupl Björn , Oellerich Thomas , Rae Zachary , Kelly Michael C. , Ahn Inhye E. , Sun Clare , Gaglione Erika M. , Wilson Wyndham H. , Wiestner Adrian , Staudt Louis M.
Published: April 2023

Supplemental Table 7. Targeting epigenetic resistance to BTK inhibitor treatment in ABC DLBCL, relates to Fig7
Klotho Supplementation Reverses Renal Dysfunction and Interstitial Fibrosis in Remnant Kidney
Authors: Takenaka Tsuneo , Hasan Arif , Marumo Takeshi , Inoue Tsutomu , Miyazaki Takashi , Suzuki Hiromichi , Kurosaki Yoshifumi , Ishii Naohito , Nishiyama Akira , Hayashi Matsuhiko
Published: April 2023

Introduction: While recent investigations show that klotho exerts renoprotective actions, it has not been fully addressed whether klotho protein supplementation reverses renal damage. Methods: The impacts of subcutaneous klotho supplementation on rats with subtotal nephrectomy were examined. Animals were divided into 3 groups: group 1 (short remnant [SR]): remnant kidney for 4 weeks, group 2 (long remnant [LR]): remnant kidney for 12 weeks, and group 3 (klotho supplementation [KL]): klotho protein (20 μg/kg/day) supplementation on the remnant kidney. Blood pressure, blood and urine compositions with conventional methods such as enzyme-linked immunosorbent assay and radioimmunoassay, kidney histology, and renal expressions of various genes were analyzed. In vitro studies were also performed to support in vivo findings. Results: Klotho protein supplementation decreased albuminuria (−43%), systolic blood pressure (−16%), fibroblast growth factor (FGF) 23 (−51%) and serum phosphate levels (−19%), renal angiotensin II concentration (−43%), fibrosis index (−70%), renal expressions of collagen I (−55%), and transforming growth factor β (−59%) (p < 0.05 for all). Klotho supplementation enhanced fractional excretion of phosphate (+45%), glomerular filtration rate (+76%), renal expressions of klotho (+148%), superoxide dismutase (+124%), and bone morphogenetic protein (BMP) 7 (+174%) (p < 0.05 for all). Conclusion: Our data indicated that klotho protein supplementation inactivated renal renin-angiotensin system, reducing blood pressure and albuminuria in remnant kidney. Furthermore, exogenous klotho protein supplementation elevated endogenous klotho expression to increase phosphate excretion with resultant reductions in FGF23 and serum phosphate. Finally, klotho supplementation reversed renal dysfunction and fibrosis in association with improved BMP7 in remnant kidney.
Risk Factors of Quality-Of-Life and Sexual Function Impairment in Chronic Spontaneous Urticaria Patients: Cross-Sectional Study
Authors: Sánchez-Díaz Manuel , Salazar-Nievas Maria Carmen , Molina-Leyva Alejandro , Arias-Santiago Salvador
Published: April 2023

Background: Chronic spontaneous urticaria (CSU) has been associated with poor quality of life and mood disturbances. However, factors associated with these dimensions have not been properly assessed. Moreover, there is a lack of studies regarding sexual dysfunction (SxD) and CSU. Therefore, the aims of this study were to assess quality of life associated factors and to evaluate the prevalence and potential impact of SxD in patients with CSU. Method: Cross-sectional study of patients suffering from CSU. Sociodemographic and disease activity variables, quality of life, sleep, SxD, anxiety, and depression were collected using validated questionnaires. Results: Seventy-five patients were included, with a female-to-male ratio of 2.40. Female sex, worse disease control, and sexual dysfunction were associated with poor quality-of-life indexes (p < 0.001). SxD was detected in 52% of female and 63% of male patients. SxD was associated with poor disease control (p < 0.001). Female SxD, but not male, was associated with poorer quality of life (p = 0.02) and an increased risk for anxiety 85% and depression 90% (p < 0.05). Conclusions: Female patients and those with an inadequate control of CSU are in higher risk of having poorer quality of life. SxD seems to be frequent in patients with CSU. Moreover, female SxD seems to have a more profound impact on quality of life and mood disturbances when compared to males. Assessment of SxD in Urticaria Clinic might be of benefit to identify patients at a higher risk of poor quality of life.
Acute Kidney Injury in Coronavirus Disease and Association with Thrombosis
Authors: Narayanan Anand , Cunningham Patrick , Mehta Malavika , Lang Theodore , Hammes Mary
Published: April 2023

Introduction: Coronavirus disease (COVID-19) is a global pandemic which continues to cause systemic inflammation, leading to multi-system organ damage including acute kidney injury (AKI) and thrombotic complications. We hypothesize that D-dimer level predicts an increased risk of AKI and thrombotic complications in COVID-19. Methods: This was a retrospective cohort study performed at a single-center academic center. Patients hospitalized with COVID-19 between January 1, 2020, and January 1, 2021, were included in the analysis. Demographics and associated medical records were reviewed from the electronic medical record. Statistical analysis was done to determine the incidence of AKI and thrombosis and if D-dimer was predictive of an adverse event. Results: The study included 389 patients with the diagnosis of COVID-19 who were hospitalized. AKI was evident in 143 patients with 59 experiencing a thrombotic event. Factors associated with AKI included age, chronic kidney disease, proteinuria, use of outpatient angiotensin-blocking medications, and D-dimer greater than 1.75 (p < 0.05). Factors associated with thrombosis included use of outpatient anticoagulants, elevated WBC, interleukin-6 (IL-6), and D-dimer greater than 1.75 (p < 0.05). When D-dimer was dichotomized at the median value for the entire dataset (value greater than 1.75), there was good discrimination for AKI and very good discrimination for thrombosis. Conclusions: Complications of acute renal failure and thrombosis are common in patients presenting with COVID-19. D-dimer was found to be predictive of both. Future studies to validate the association of these two events in patients presenting with COVID-19 are warranted as early treatment with antithrombotic agents may have a role in preventing adverse sequelae and outcomes.
Genetic Determinants of the Interventricular Septum Are Linked to Ventricular Septal Defects and Hypertrophic Cardiomyopathy
Authors: Yu Mengyao , Harper Andrew R. , Aguirre Matthew , Pittman Maureen , Tcheandjieu Catherine , Amgalan Dulguun , Grace Christopher , Goel Anuj , Farrall Martin , Xiao Ke , Engreitz Jesse , Pollard Katherine S. , Watkins Hugh , Priest James R.
Published: April 2023

Background:

A large proportion of genetic risk remains unexplained for structural heart disease involving the interventricular septum (IVS) including hypertrophic cardiomyopathy and ventricular septal defects. This study sought to develop a reproducible proxy of IVS structure from standard medical imaging, discover novel genetic determinants of IVS structure, and relate these loci to diseases of the IVS, hypertrophic cardiomyopathy, and ventricular septal defect.

Methods:

We estimated the cross-sectional area of the IVS from the 4-chamber view of cardiac magnetic resonance imaging in 32 219 individuals from the UK Biobank which was used as the basis of genome wide association studies and Mendelian randomization.

Results:

Measures of IVS cross-sectional area at diastole were a strong proxy for the 3-dimensional volume of the IVS (Pearson
r
=0.814,
P
=0.004), and correlated with anthropometric measures, blood pressure, and diagnostic codes related to cardiovascular physiology. Seven loci with clear genomic consequence and relevance to cardiovascular biology were uncovered by genome wide association studies, most notably a single nucleotide polymorphism in an intron of
CDKN1A
(rs2376620; β, 7.7 mm
2
[95% CI, 5.8–11.0];
P
=6.0×10
−10
), and a common inversion incorporating
KANSL1
predicted to disrupt local chromatin structure (β, 8.4 mm
2
[95% CI, 6.3–10.9];
P
=4.2×10
−14
). Mendelian randomization suggested that inheritance of larger IVS cross-sectional area at diastole was strongly associated with hypertrophic cardiomyopathy risk (p
IVW
=4.6×10
−10
) while inheritance of smaller IVS cross-sectional area at diastole was associated with risk for ventricular septal defect (p
IVW
=0.007).

Conclusions:

Automated estimates of cross-sectional area of the IVS supports discovery of novel loci related to cardiac development and Mendelian disease. Inheritance of genetic liability for either small or large IVS, appears to confer risk for ventricular septal defect or hypertrophic cardiomyopathy, respectively. These data suggest that a proportion of risk for structural and congenital heart disease can be localized to the common genetic determinants of size and shape of cardiovascular anatomy.
Longitudinal Trends in Cardiovascular Risk Factor Profiles and Complications Among Patients Hospitalized for COVID-19 Infection: Results From the American Heart Association COVID-19 Cardiovascular Disease Registry
Authors: Hall Eric J. , Ayers Colby R. , Kolkailah Ahmed A. , Rutan Christine , Walchok Jason , Williams Joseph H. , Wang Tracy Y. , Rodriguez Fatima , Bradley Steven M. , Stevens Laura , Hall Jennifer L. , Mallya Pratheek , Roth Gregory A. , Morrow David A. , Elkind Mitchell S.V. , Das Sandeep R. , de Lemos James A.
Published: April 2023

Background:

The COVID-19 pandemic has evolved through multiple phases characterized by new viral variants, vaccine development, and changes in therapies. It is unknown whether rates of cardiovascular disease (CVD) risk factor profiles and complications have changed over time.

Methods:

We analyzed the American Heart Association COVID-19 CVD registry, a national multicenter registry of hospitalized adults with active COVID-19 infection. The time period from April 2020 to December 2021 was divided into 3-month epochs, with March 2020 analyzed separately as a potential outlier. Participating centers varied over the study period. Trends in all-cause in-hospital mortality, CVD risk factors, and in-hospital CVD outcomes, including a composite primary outcome of cardiovascular death, cardiogenic shock, new heart failure, stroke, and myocardial infarction, were evaluated across time epochs. Risk-adjusted analyses were performed using generalized linear mixed-effects models.

Results:

A total of 46 007 patient admissions from 134 hospitals were included (mean patient age 61.8 years, 53% male, 22% Black race). Patients admitted later in the pandemic were younger, more likely obese, and less likely to have existing CVD (
P
trend
≤0.001 for each). The incidence of the primary outcome increased from 7.0% in March 2020 to 9.8% in October to December 2021 (risk-adjusted
P
trend
=0.006). This was driven by an increase in the diagnosis of myocardial infarction and stroke (
P
trend
<0.0001 for each). The overall rate of in-hospital mortality was 14.2%, which declined over time (20.8% in March 2020 versus 10.8% in the last epoch; adjusted
P
trend
<0.0001). When the analysis was restricted to July 2020 to December 2021, no temporal change in all-cause mortality was seen (adjusted
P
trend
=0.63).

Conclusions:

Despite a shifting risk factor profile toward a younger population with lower rates of established CVD, the incidence of diagnosed cardiovascular complications of COVID increased from the onset of the pandemic through December 2021. All-cause mortality decreased during the initial months of the pandemic and thereafter remained consistently high through December 2021.
Musical Evidence for Low Boundary Tones in Ancient Greek
Authors: Gunkel Dieter
Published: April 2023

Several scholars have suggested that in ancient Greek there was a low boundary tone at the end of a relatively small prosodic constituent such as a clitic group or maximal prosodic word. The boundary tone may phonologically motivate some puzzling pitch-accentual phenomena in the language. One is the diachronic pitch-peak retraction that led to the circumflex pitch accent (HL) on penultimate syllables (the “sōtêra rule”). Another is the intonational phrase-internal downstepping or deletion of a word-final acute accent (H); that conversion of an acute to a grave accent is known as “lulling” or “koímēsis”. If such a low boundary tone existed, its effects should still be audible in ancient Greek non-strophic vocal music, where there is a significant correlation between the pitch movement of the text and the movement of the melody to which it is set, i.e. between tone and tune. Specifically, proponents of such a low boundary tone would predict that the turning point between falling and rising melody, the “musical trough”, should center around the word-final mora or syllable. The present study provides the first full description of troughs in the Delphic Hymns and finds that they are indeed closely aligned with word-end. Furthermore, once other factors that could lead to word-final troughs are set aside, i.e. once potential confounds are controlled for, the association of the trough with word-end remains strong, suggesting that we should in fact reconstruct the low boundary tone.
Telling, Gathering and (Re)Experiencing Stories: Video Interview as Methodology and Innovation in Practitioner-Based Research
Authors: Dunham Nicola , Chant Lisa
Published: April 2023

This article explores the use of video as both an interview technique for data collection and for research dissemination. Attention is given to ways in which video interviews gathered as part of the Maraea community research project were reframed in the development of a virtual reality experience. Maraea is a research project conducted between 2017–2020. A comparative methodology was used to gather knowledge on indigenous-health-practitioner-led community-based solutions from New Zealand, Australia, Canada and the USA that focus on whānau rangatiratanga / family self-determination. Although the video interviews have been disseminated through an official Maraea website, the authors explored ways to reframe or (re)experience the stories being told. An immersive virtual reality (vr) prototype was created to explore the potential to bring the user / learner / audience closer to the narrative, to the practitioner telling their story and therefore to the practices being shared.
Wallace Stevens
Authors: Hederman Mark Patrick
Published: April 2023

This paper hopes to show that, for Wallace Stevens, God and human imagination are closely identified. Moreover, the feeling of rightness, which for so long a time existed with the old religious idea of God, may be accessed once again. His notion of the “supreme fiction” will compare with Descartes’ “idea of the Infinite” as interpreted by Emmanuel Levinas. This epistemological reality, central to our being, can also become contemporary to our lives, in a way that the old religious idea of God can never again be. With access to this “right idea,” we may again find the sort of solace that we once found in old religious beliefs.
The diatom genus Longinata Hajós (Bacillariophyta): structure, relationships and distribution
Authors: WILLIAMS DAVID M. , SIMS PAT A.
Published: April 2023

The diatom genus Longinata Hajós was first described from an Upper Cretaceous DSDP core. Its description was rudimentary with just a single light micrograph of the holotype. In this contribution we re-describe the species Longinata acuta using light and electron microscopy from specimens found in the same core, clarify what the type specimens are and the slide they come from, transfer Eunotogramma fueloepi Hajós to Longinata and provide a few comments on its relationships.
New dark species of Cribraria (Myxomycetes) from wetland ecosystem in Tatarstan (Russia)
Authors: SADYKOV RUSLAN E. , POTAPOV KIM O.
Published: April 2023

Fruiting bodies of a grey-coloured Cribraria were found in moist chambers on dead wood of Salix from a wetland ecosystem in Kazan (Tatarstan, Russia). Morphological analysis showed that the species, described as Cribraria gothica, probably belongs to a group with C. tenella and C. languescens, but differs in many respects. Most vivid factors are plumbeous colour of sporocysts, small grey spores and creamy-coloured top of stalk. The comparative characteristic and a key to these related species are given.
The correct spelling of an “espinheira-santa” species (Monteverdia, Celastraceae): aquifolium vs. aquifolia
Authors: BIRAL LEONARDO
Published: April 2023

N/A
Five new species of the pelodryadid genus Litoria Tschudi from the southern versant of Papua New Guinea’s Central Cordillera, with observations on the diversification of reproductive strategies in Melanesian treefrogs
Authors: RICHARDS STEPHEN J. , DONNELLAN STEPHEN C. , OLIVER PAUL M.
Published: April 2023

New Guinea has the most diverse insular frog fauna in the world, and rates of species discovery and description have increased rapidly in the last two decades. Pelodryadid treefrogs are the second most diverse family of anurans on the island but their taxonomy, relationships, and especially ecology remain poorly documented. Based on differences in morphology, advertisement calls (where available) and phylogenetic analyses of a 787 base pair alignment from the mitochondrial ND4 gene and flanking tRNA, we describe five new species of small treefrogs from hill and lower montane forests in the high rainfall belt that straddles the southern versant of Papua New Guinea’s Central Cordillera. Three of these species are known only from forest growing on karst substrates, adding to the growing number of herpetofauna species currently known only from the extensive karst habitats of Papua New Guinea’s South-fold Mountains. We also describe the arboreal breeding strategies of two of the new species, and report obligate treehole (phytotelm) breeding in New Guinean frogs for the first time. The new phytotelm–breeding species has juveniles with colour and patterning that closely resemble bird droppings, suggesting defensive mimicry or masquerade. A preliminary phylogeny suggests that arboreal-breeding frogs do not form a monophyletic group and that arboreal breeding has evolved multiple times within the New Guinean pelodryadid radiation. A further striking feature of the phylogeny is poor support for most basal nodes in the most diverse radiation of Melanesian Pelodryadidae, suggesting rapid ecological diversification and speciation, potentially following colonisation from Australia and/or mountain uplift. These new taxa and observations highlight previously unrecognised ecological and reproductive diversity in the Melanesian Pelodryadidae.
Description of three new species and one new genus in American Acanthocinini (Coleoptera, Cerambycidae)
Authors: SANTOS-SILVA ANTONIO , MONNÉ MIGUEL A.
Published: April 2023

Three new species of Acanthocinini are described: Pseudosparna swifti sp. nov., from Costa Rica; Pseudosparna paulista sp. nov., from Brazil; and Xenocona chulumani sp. nov., from Bolivia. A new genus of Acanthocinini is described to include Pseudolepturges caesius Monné & Monné, 2007, and it is included in a previous key.
The Use of Small Uncrewed Aircraft System Observations in Meteorological and Dispersion Modeling
Authors: Ngan Fong , Loughner Christopher P. , Zinn Sonny , Cohen Mark , Lee Temple R. , Dumas Edward , Schuyler Travis J. , Baker C. Bruce , Maloney Joseph , Hotz David , Mathews George
Published: April 2023

A series of meteorological measurements with a small uncrewed aircraft system (sUAS) was collected at Oliver Springs Airport in Tennessee. The sUAS provides a unique observing system capable of obtaining vertical profiles of meteorological data within the lowest few hundred meters of the boundary layer. The measurements benefit simulated plume predictions by providing more accurate meteorological data to a dispersion model. The sUAS profiles can be used directly to drive HYSPLIT dispersion simulations. When using sUAS data covering a small domain near a release and meteorological model fields covering a larger domain, simulated pollutants may be artificially increased or decreased near the domain boundary because of inconsistencies in the wind fields between the two meteorological inputs. Numerical experiments using the Weather Research and Forecasting (WRF) Model with observational nudging reveal that incorporating sUAS data improves simulated wind fields and can significantly affect mixing characteristics of the boundary layer, especially during the morning transition period of the planetary boundary layer. We conducted HYSPLIT dispersion simulations for hypothetical releases for three case study periods using WRF meteorological fields with and without assimilating sUAS measurements. The comparison of dispersion results on 15 and 16 December 2021 shows that using sUAS observational nudging is more significant under weak synoptic conditions than under strong influences from regional weather. Very different dispersion results were introduced by the meteorological fields used. The observational nudging produced not just an sUAS-nudged wind flow but also adjusted meteorological fields that further impacted the mixing calculation in HYSPLIT.
The Play of Mourning
Authors: Cooper Steven H.
Published: April 2023

Playing is a form of responsiveness that involves a shift from more formal interpretation about defense, unconscious fantasy, or transference to one that employs humor or irony regarding the content of fantasy or poses a more direct confrontation between internal fantasy and external reality. Playing is differentiated from more formal interpretation by the analytic couple’s intensity of affective expression, the idiomatic language used to express affect or ideas, or the analyst’s more personally revealing reaction to the patient’s recruitment of him as an internal object. Two clinical vignettes show how play emphasizes experiences of loss and waste that have been enacted in the patient’s life and often in transference-countertransference engagement. Through newly discovered forms of play, these processes are occurring now in real time between patient and analyst and less through frozen memorialization of what never was.
How Great is the Current Danger to Democracy? Assessing the Risk With Historical Data
Authors: Treisman Daniel
Published: April 2023

Influential voices contend that democracy is in decline worldwide and threatened in the US. Using a variety of measures, I show that—while there has been some recent backsliding—the global proportion of democracies remains close to an all-time high. The current rate of deterioration is not historically unusual and is well explained by the lower income and unseasoned institutions of many new democracies swept upwards in the Third Wave. Historical data suggest the probability of democratic breakdown in the US is extremely low. Western governments are seen as threatened by weakening popular support for democracy and an erosion of elite norms. But systematic evidence for these claims is very limited. While eroding democratic quality in some countries is indeed a cause for concern, the fear of a global slide into autocracy appears premature.
Coping with H-1B Shortages: Firm Performance and Mitigation Strategies
Authors: Mayda Anna Maria , Ortega Francesc , Peri Giovanni , Shih Kevin , Sparber Chad
Published: April 2023

The H-1B visa program allows companies to hire skilled foreign workers. Before 2014, the vast majority of these visas were allocated on a first-come-first-served basis. Since then, the program has been severely oversubscribed and all cap-subject visas have been allocated through lotteries. The authors merged Compustat data with administrative firm-level data on the universe of approved petitions for H-1B visas. Using difference-in-differences and matching estimators, this article finds that the switch in the visa allocation system negatively affected the growth of companies that used the H-1B program. Results indicate that these effects are quantitatively large and that their magnitudes grow over time.
How Consumers Resolve Conflict over Branded Products: Evidence from Mouse Cursor Trajectories
Authors: Fisher Geoffrey , Woolley Kaitlin
Published: April 2023

Consumers differ in the extent to which brands drive their choices. The current research investigates the psychology underlying such decisions by using a cursor-tracking paradigm that captures consumers’ decision-making processes in real time. Results indicate that while consumers typically process brand attributes relatively later than product attributes, the timing of this processing varies across individuals and affects choice. Specifically, when consumers trade off brand and product desirability (i.e., when deciding between a more [less] preferred product from a less [more] preferred brand), the earlier that brand attributes are considered, the more likely consumers are to choose the option from the preferred brand. Increasing the prominence of brand (vs. product) attributes leads to earlier brand attribute processing and a higher likelihood of choosing the preferred brand. These findings hold across a limited number of choice trials and for decisions involving three attributes (brand, product, and price). This research highlights the applicability of cursor tracking in revealing the psychological drivers of consumer choices in real time.
The Influence of the Health Belief Model on the Decision to Get the COVID-19 Vaccine: An International Survey Study of College Students
Authors: Berger Corinne , Ben-Shalom Uzi , Tarant Zbyněk , Longo Joy , DeDonno Michael
Published: April 2023

To better prepare for a potential future pandemic, it is important to investigate factors that influenced responses to the recent COVID-19 pandemic. The aim of the present study was to investigate factors that influenced the decision to get the COVID-19 vaccine. The COVID-19 pandemic has affected almost everyone throughout the world. Vaccines are a significant factor in managing a pandemic. As vaccines are developed, governments develop vaccine roll-out plans. Unfortunately, vaccine hesitancies can slow the implementation of any vaccine program. A question arises as to the factors that are associated with the decision to get vaccinated. The present study explored associations between vaccine hesitancy, and the Health Belief Model (HBM) in student samples from the Czech Republic, Israel, and the United States. From August, 2021 through December, 2021, an online survey was distributed in Czech, Hebrew, and English. A total of 447 participants completed the survey. A binomial logistic regression was conducted to ascertain the influence of perceived susceptibility, severity, benefits, and barriers on the likelihood that participants are vaccinated. Results revealed that the factors of perceived severity and perceived benefits explained 52.6% (Nagelkerke R2) of the variance in vaccination. An analysis of Variance (ANOVA) found significant differences between countries for the 4 HBM factors. Based on these findings, it is recommended that policymakers put forth added emphasis on the severity of a virus and the benefits associated with the vaccine. Further, since there appears to be variability between countries in perceptions of the virus, and associated vaccine, governments should consider factors within their own environment when developing a strategy to combat a pandemic. More specifically, government could explore their own strengths, weaknesses, opportunities, and threats as they develop a pandemic strategy. Additional practical and theoretical implications are discussed.
Clinical Application of the Residual Thyroid Cartilage for Laryngeal Function Reconstruction in the Partial Laryngectomy—A Single Center Experience
Authors: Li Pingdong , Zhou Jing , Yang Zheng , Chen Xuejun , Chen Xiaohong , Huang Zhigang
Published: April 2023

Background

To investigate the outcomes of using the residual thyroid cartilage for laryngeal function reconstruction in early glottic laryngeal carcinoma.

Methods

From March 2017 to June 2022, 21 patients with glottic carcinoma who underwent laryngeal function reconstruction were analyzed retrospectively. The operation was performed under general anesthesia. Reconstruction of ipsilateral hemilarynx defect by downward movement of ipsilateral residual thyroid cartilage plate. During the follow-up period, the laryngeal function and tumor recurrence were evaluated.

Results

otally 20 male patients and 1 female patient were enrolled in this study. Of the 20 initial primary tumors, there were 6 patients with T1N0M0 stage, 12 ones with T2N0M0 stage, 1 with T1N1M0 stage, 1 with T3N0M0 stage, and 1 with T2N1M0 stage. The patient with recurrent tumor was T3N1M0 stage. The follow-up time ranged from 9 to 63 months. All patients were healed by first intention after surgery. All patients without laryngeal stenosis were removed from tracheotomy tube. So far, all patients have good laryngeal function. One patient relapsed at the last follow-up.

Conclusion

It is safe to repair hemilarynx defect with residual thyroid cartilage plate on the affected side, and it is an important choice for laryngeal function reconstruction after vertical partial laryngectomy.
The structure of mental well-being and its relationship with generativity in middle adulthood and the beginning of late adulthood
Authors: Reinilä Emmi , Kekäläinen Tiia , Saajanaho Milla , Kokko Katja
Published: April 2023

Previous studies have linked higher generativity with better mental well-being. However, most of these studies investigated the predictive role of generativity in well-being, while the converse relation, that is, how mental well-being contributes to generativity, has been ignored. This study first investigated the structure and stability of multidimensional mental well-being, that is, emotional (including happiness, life satisfaction, and positive and negative mood), psychological, and social well-being and the absence of depressive feelings, from age 42 to 61. Second, longitudinal associations between mental well-being and generativity were examined. The data ( n = 301) utilized in this study were drawn from the Jyväskylä Longitudinal Study of Personality and Social Development and were collected using self-report questionnaires and psychological interviews at the ages of 42, 50, and 61. Using structural equation modeling, the multidimensional structure of mental well-being showed partial strong factorial invariance and high stability from age 42 to 61. The associations between mental well-being (both the multidimensional factor and the single indicators) and generativity were tested using the random intercept cross-lagged panel model. Stable, trait-like associations were found between multidimensional, emotional, and psychological well-being and generativity. The longitudinal results showed that social well-being at age 42 predicted generativity at age 50. To conclude, multidimensional mental well-being seemed to remain stable from middle adulthood to the beginning of late adulthood. Furthermore, mental well-being and generativity may be linked at both the between- and within-person levels. In particular, social well-being appeared to be a resource through which individuals could increase their generativity.
How to Problematize the Global?
Authors: Witt Antonia , Anderl Felix , Acharya Amitav , Shahi Deepshikha , Kamola Isaac , Cornelissen Scarlett
Published: April 2023

International Relations (IR) has long been criticized for taking a particular (Western) experience as basis for formulating theories with claim to universal validity. In response, recent discussions have therefore centered on making IR ‘truly global’, that is, more inclusive and less parochial in its language and substance. But the concept of the global underpinning this discussion is both illusive and strongly contested. It requires problematization. But how? In this Forum, scholars discuss this question with a forward-looking agenda. Building on recent critical engagements with the question of the global as a concept in general and Global IR specifically, the authors ask how the global should be problematized in order to achieve a (more) progressive agenda for IR. They draw on different regional and disciplinary perspectives to both further the agenda of a less exclusive and racist discipline without falling into the trap of shallow inclusivity, and to discuss ways of problematizing the global without falling back into nativism or nationalism.