bluuebunny/crossref_metadata_2025 huggingface dataset:
Norrby Formulas for IOL Power Calculation
Authors: Norrby Sverker
Published: July 2024

This chapter gives Norrby’s background in optics as researcher working for a major international IOL manufacturer and his early and subsequent work in the optics and development of IOL power calculation formulas. He has developed three formulas for IOL power (Norrby thick lens formula, Norrby thin lens formula, and Norrby regression formula), which are thoroughly documented here. This comprehensive effort was first presented a decade ago but never published until now, in this chapter. Since he has now completely retired from the field, it will be up to others to test the benefit of his theories in clinical practice and compare them to the other new formulas using artificial intelligence and special algorithms.
The Olsen Formula
Authors: Olsen Thomas
Published: July 2024

The ambition of the Olsen formula was to develop a thick-lens formula based on paraxial ray tracing as assumption-free as possible allowing for a full-thickness calculation of the cornea and the IOL power and the use of real physical dimensions—including the physical position of the IOL—to be used in the formula. From 2012, the Olsen formula was modified to allow exact ray tracing on aspheric surfaces to include the effect of spherical aberration. The prediction of the IOL position has been improved over the years based on numerous clinical measurements of the actual IOL position and the correlation with relevant preoperative clinical parameters (see chapter on ELP estimation). An important step was the development of the C-constant concept which predicts the IOL position as a fraction of the preoperative lens thickness, thereby reducing the number of indirect parameters in the algorithm.
Online IOL Power Calculators
Authors: Hoffer Kenneth J. , Ribeiro Filomena , Savini Giacomo
Published: July 2024

This chapter aims to provide readers with the latest online intraocular (IOL) power calculators developed by individual ophthalmologists and researchers to improve the refractive outcomes of cataract surgery. Means to access them and utilize a newer website that congregates them all on the website will be presented.
Power Calculations for Spherical and Toric Phakic IOLs
Authors: Sarver Edwin J.
Published: July 2024

In this chapter, methods for the calculation of stigmatic and toric phakic IOL (TPIOL) powers are presented. These methods include calculations for the ideal TPIOL power for a given eye and desired postoperative spectacle power, the prediction of the postoperative spectacle power for a selected TPIOL power different from the ideal power, the calculation of an exchange TPIOL in the event of an unacceptable refractive surprise, and the calculation of a lens position parameter on a per-case basis to provide a means of building a data set to optimize the predictability of future cases. Sample calculations are presented to demonstrate the use of these equations.
IOL Power Calculation in Long Eye
Authors: Wang Li , Bezerra Rachel Lopes Franke , Koch Douglas D.
Published: July 2024

Inaccurate measurement of preoperative axial length is the main reason for postoperative refractive error in axial high myopia. When axial length is measured by optical biometry, the adoption of the original formula to transform the optical path length into a geometrical path length leads to overestimation of axial length in myopic eyes. The group refractive index adopted to calibrate optical biometry and immersion ultrasound biometry, in fact, does not take the different relative lengths of the ocular segments into account. Segmented axial length, which is obtained by adding the individual geometrical path length of cornea, aqueous depth, lens thickness, and vitreous chamber depth, provides more accurate axial length measurements in long eyes.

Axial length adjustment methods (Wang-Koch adjustment) have been developed and refined to improve the refractive outcome of traditional formulas (Holladay 1, Holladay 2 and SRK/T). Similar adjustments are included in newer formulas and lead to better results compared to the original axial length measurements.
IOL Power Calculation in the Short Eye
Authors: Flikier David
Published: July 2024

Short eyes include simple microphthalmos, complex microphthalmos, nanophthalmos, relative anterior microphthalmos, and posterior microphthalmos. The definition of each of these subgroups is given, as well as the possible genetic mutations leading to these anatomical characteristics.

In short eyes, the ELP prediction is a critical parameter for IOL power calculation. Formulas that take both the anterior chamber depth and lens thickness into account are likely to achieve more accurate outcomes, but the results are still far from being perfect with more than 40% of eyes showing a prediction error >±0.50 D when the axial length is <21.5 mm. Primary and secondary piggy-back implantation is reviewed.
IOL Power Calculation After Corneal Refractive Surgery
Authors: Aramberri Jaime , Savini Giacomo , Hoffer Kenneth J.
Published: July 2024

Intraocular lens (IOL) power calculation is affected by the effect of any previous corneal refractive surgery. In this chapter, an extensive analysis of the different sources of error and the correspondent solutions is performed. Corneal shape change and keratometric error are the main contributors to the final refractive error. Incorrect IOL position estimation is another potential cause of error in determined formulas. New corneal tomographers and the use of a correct calculation method will improve the outcomes avoiding the commission of significant errors. A classification of the published methods to be used in these cases with their performance data will allow the surgeon to select the best option in each particular case.
Patient-Specific Eye Models for Intraocular Lens Power Calculation in Irregular Corneas
Authors: Pérez-Merino Pablo
Published: July 2024

Intraocular lens (IOL) power calculation is normally performed using theoretical Gaussian formulas. Paraxial calculation renders clinically acceptable outcomes in normal eyes with regular corneal shape and optics but leads to refractive error whenever the cornea is irregular in terms of anterior surface shape or anterior to posterior curvature proportions. The most prevalent conditions are keratoconus, keratoplasty, or corneas that have undergone refractive surgery, especially with old techniques. In this chapter, a more robust calculation methodology is proposed based on a three-dimensional model of the cornea constructed from tomographic data. Optical calculations are done by exact ray tracing, overcoming the limitations of the paraxial constraints and managing adequately the effect of higher-order aberrations. Image quality metrics that correlates with subjective vision will be used as a target to determine the best IOL sphere and cylinder power.
Spinning primordial black holes from first order phase transition
Authors: Banerjee Indra Kumar , Dey Ujjal Kumar
Published: July 2024

Abstract

We conduct a novel study to obtain the initial spin of the primordial black holes created during a first-order phase transition due to delayed false vacuum decay. Remaining within the parameter space consistent with observational bounds, we express the abundance and the initial spin of the primordial black holes as functions of the phase transition parameters. The abundance of the primordial black holes is extremely sensitive to the phase transition parameters. We also find that the initial spin weakly depends on all parameters except the transition temperature.
Geometry from integrability: multi-leg fishnet integrals in two dimensions
Authors: Duhr Claude , Klemm Albrecht , Loebbert Florian , Nega Christoph , Porkert Franziska
Published: July 2024

Abstract

We generalise the geometric analysis of square fishnet integrals in two dimensions to the case of hexagonal fishnets with three-point vertices. Our results support the conjecture that fishnet Feynman integrals in two dimensions, together with their associated geometry, are completely fixed by their Yangian and permutation symmetries. As a new feature for the hexagonal fishnets, the star-triangle identity introduces an ambiguity in the graph representation of a given Feynman integral. This translates into a map between different geometric interpretations attached to a graph. We demonstrate explicitly how these fishnet integrals can be understood as Calabi-Yau varieties, whose Picard-Fuchs ideals are generated by the Yangian over the conformal algebra. In analogy to elliptic curves, which represent the simplest examples of fishnet integrals with four-point vertices, we find that the simplest examples of three-point fishnets correspond to Picard curves with natural generalisations at higher loop orders.
The NNLO gluon beam function for jet-veto resummation
Authors: Bell Guido , Brune Kevin , Das Goutam , Shao Ding Yu , Wald Marcel
Published: July 2024

Abstract

We compute the gluon beam function for jet-veto resummation to next-to-next-to-leading order (NNLO) in the strong-coupling expansion. Our calculation is based on an automated framework that was previously used for the computation of the respective quark beam function, and which we significantly extended for the present calculation. In particular, the perturbative matching kernels are directly calculated in momentum space, without the need to perform an additional Mellin transform. We present results for both gluon and quark-initiated processes, which we cross-checked with an independent semi-analytical method that exploits the similarity of the beam functions to the more familiar case of transverse-momentum resummation. Our computation is relevant for jet-veto resummations at NNLL′ accuracy.
Tropical convexity in location problems
Authors: Comăneci Andrei
Published: July 2024

We investigate location problems where the optimal solution is found within the tropical convex hull of the given input points. Our initial focus is on geodesically star-convex sets, using the asymmetric tropical distance. We introduce the concept of tropically quasiconvex functions, which have sub-level sets with this shape, and are closely related to monotonic functions. Our findings demonstrate that location problems using tropically quasiconvex functions as distance measures will result in an optimal solution within the tropical convex hull of the input points. We also extend this result to cases where the input points are replaced with tropically convex sets. Finally, we explore the applications of our research in phylogenetics, highlighting the properties of consensus methods that arise from our class of location problems.
Widespread haemorrhages in infants post-shunting (WHIPS): clinical features, risk factors and neuroimaging characteristics of a rare and under-recognised phenomenon
Authors: Lakshmanan Rahul , Abu Hassan Fariza , Dissanayake Shashini , Crabtree Harriet , McLaughlin Aden , Cooper Matthew , Lee Sharon , Warne Richard , Shipman Peter
Published: July 2024

Purpose

Infants undergoing CSF shunting procedures face a rare complication which we propose to rename “Widespread Haemorrhages in Infants Post-Shunting” (WHIPS) to better capture this unique phenomenon specific to infants undergoing CSF diversion. Our objective is to analyse the risk factors for WHIPS development and provide a detailed neuroradiological description of these haemorrhages.

Materials and methods

A radiology information system (RIS) was searched using the search terms “shunt” and/or “catheter” and/or “drain” and/or “ventriculoperitoneal” and/or “VP” between September 2008 to January 2021 for patients < 12 months of age. Clinical data was compiled for each patient meeting the inclusion criteria. Included cases were reviewed by three radiologists for the presence of WHIPS with calculation of the bifrontal ratio and documenting haemorrhage number, morphology, location and lobar distribution.

Results

51 patients met inclusion criteria, 8 WHIPS patients and 43 controls. There was a statistically significant correlation between a larger post-op head circumference and WHIPS (p = 0.04). WHIPS was associated with post-haemorrhagic hydrocephalus and post-infectious hydrocephalus (p = 0.009). WHIPS were identified in the cortico-subcortical regions, periventricular white matter, and deep white matter. Haemorrhages were either punctate, ovoid or confluent. Haemorrhages ranged from single to innumerable.

Conclusions

WHIPS represent a rare and under-recognised complication of CSF shunting unique to the infantile population. We postulate deep and superficial medullary venous haemorrhage as an underlying mechanism related to disordered intracranial hydrodynamics which are exacerbated in the infantile population due to underdeveloped arachnoid granulations and a compliant skull.
Association of health-related quality of life with urinary tract infection among kidney stone formers
Authors: Wang Mingrui , Lai Chin-Hui , Ji Jiaxiang , Hu Haopu , Ni Runfeng , Liu Jun , Yu Luping , Hu Hao
Published: July 2024

Kidney stones and infections significantly affect patients’ health-related quality of life (HRQOL); however, the relationship between urinary tract infections (UTIs) and HRQOL in patients with kidney stones remains unclear. This study aimed to investigate the relationship using the validated Chinese version of the Wisconsin Stone Quality of Life questionnaire (C-WISQOL). We prospectively recruited 307 patients with kidney stones to complete the C-WISQOL before and after stone removal. The participants were diagnosed with UTI based on the presence of pyuria or bacteriuria with or without clinical symptoms. The psychometric properties of the C-WISQOL were statistically analyzed. Multivariate linear regression was used to predict the risk factors for impaired HRQOL in patients with stones and UTIs. The questionnaire is a reliable and robust tool for evaluating HRQOL in Chinese-speaking patients with urolithiasis. The UTI and kidney stone co-occurrence was significantly associated with female sex, diabetes mellitus, more previous stone events, higher antibiotic usage, positive stone- or UTI-related symptoms, and postoperative residual stones. The preoperative C-WISQOL scores and improvement in the HRQOL after stone removal in patients clinically diagnosed with UTI were significantly inferior to those in patients without UTI. The regression analyses showed that worse HRQOL was predicted by more previous stone events and positive stone- or UTI-related symptoms. In contrast, the presence of diabetes mellitus and postoperative residual stone fragments predicted a lower improvement in the HRQOL. These findings underscore UTI’s harmful impact on perioperative HRQOL in patients with kidney stones and could help strategies benefit those patients.
Adult acute leukemia patients with gram-negative bacteria bloodstream infection: Risk factors and outcomes of antibiotic-resistant bacteria
Authors: Wang Jinjin , Mu Mingchun , Zhu Jinbing , Yang Jinrong , Tao Yali , Chen Yuhui , Hu Qian , Zhou Hui , Zhao Ailin , Niu Ting
Published: July 2024

This study aims to analyze the risk factors for the development of multidrug-resistant (MDR) and carbapenem-resistant (CR) bacteria bloodstream infection (BSI) in a patient with acute leukemia (AL) and the mortality in gram-negative bacteria (GNB) BSI. This is a retrospective study conducted at West China Hospital of Sichuan University, which included patients diagnosed with AL and concomitant GNB BSI from 2016 to 2021. A total of 206 patients with GNB BSI in AL were included. The 30-day mortality rate for all patients was 26.2%, with rates of 25.8% for those with MDR GNB BSI and 59.1% for those with CR GNB BSI. Univariate and multivariate analyses revealed that exposure to quinolones (Odds ratio (OR) = 3.111, 95% confidence interval (95%CI): 1.623–5.964, p = 0.001) within the preceding 30 days was an independent risk factor for MDR GNB BSI, while placement of urinary catheter (OR = 6.311, 95%CI: 2.478–16.073, p < 0.001) and exposure to cephalosporins (OR = 2.340, 95%CI: 1.090–5.025, p = 0.029) and carbapenems (OR = 2.558, 95%CI: 1.190–5.497, p = 0.016) within the preceding 30 days were independently associated with CR GNB BSI. Additionally, CR GNB BSI (OR = 2.960, 95% CI: 1.016–8.624, p = 0.047), relapsed/refractory AL (OR = 3.035, 95% CI: 1.265–7.354, p = 0.013), septic shock (OR = 5.108, 95% CI: 1.794–14.547, p = 0.002), platelets < 30 × 109/L before BSI (OR = 7.785, 95% CI: 2.055–29.492, p = 0.003), and inappropriate empiric antibiotic therapy (OR = 3.140, 95% CI: 1.171–8.417, p = 0.023) were independent risk factors for 30-day mortality in AL patients with GNB BSI. Prior antibiotic exposure was a significant factor in the occurrence of MDR GNB BSI and CR GNB BSI. CR GNB BSI increased the risk of mortality in AL patients with GNB BSI.
Olive stone powder filled bio-based polyamide 5.6 biocomposites: biodegradation in natural soil and mechanical properties
Authors: Gülel Şebnem , Güvenilir Yüksel
Published: July 2024

The extensive use of non-biodegradable and petroleum derived polymers in industry exacerbates environmental problems associated with plastic waste accumulation and fossil resource depletion. The most promising solution to overcome this issue is the replacement of these polymers with biodegradable and bio-based polymers. In this paper, novel biocomposites were prepared from bio-based polyamide 5.6 (PA56) with the addition of olive stone powder (OSP) at varying weight concentrations by melt compounding method. The degradability of the prepared biocomposites is investigated through soil burial test, and assessed by reduction in their mechanical properties. The biodegradability of bio-based polyamide 5.6 is shown to be improved by addition of olive stone powder, and its effects on the properties of polymer matrix are elucidated. The Fourier transform infrared (FTIR) spectrum of the biocomposites indicate the successful incorporation of OSP into PA56 polymer matrix. After six-month soil burial test, scanning electron microscopy and FTIR show the degradation of PA56 through morphological and structural changes, respectively. Differential scanning calorimetry reveals the changes in the transition temperatures of the polymer matrix and an increase in crystallinity. Thermogravimetric analysis is used on the biocomposite to determine the fraction of its components, polymer and biofiller, and the results show that 2.67% (w/w) of the polyamide 5.6 is biodegraded at the end of the six-month soil burial.
Advances in mechanical and physicochemical performances of recycled carbon fiber reinforced PEKK composites
Authors: Yildirimoglu Yasemin Sumeyye , Ozturk Fahrettin
Published: July 2024

In recent years, waste storage and recycling have been important issues. All efforts shown in these fields aim to help resolve concerns related to climate change. In this study, recycled CF/PEKK thermoplastic composite materials were reviewed to reduce the environmental impact of materials during the production phase as well as economic costs and ensure product continuity. Comparisons between unprocessed or virgin material and recycled materials were performed by bending and interlaminar shear strength (ILSS) analyses. In addition to mechanical tests, physicochemical tests such as differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), and fiber void ratio (FVC)-porosity tests were conducted. Images of the samples were observed by scanning electron microscopy (SEM) to interpret changes in the structure before and after the recycling. According to the experimental results, it was found that the virgin thermoplastic composite showed 68.05% higher flexural strength and 7.85% higher flexural modulus compared to the recycled thermoplastic composites. The average ILSSs were measured as 81.8 MPa and 64.7 MPa for the virgin and the recycled thermoplastic composites, respectively. Hence, it is obvious that the recycled composites could be used for applications that require less strength and durability. Finally, it was concluded that recyclable materials can be reused in the aero structures.
Mentalizing impairments and hypermentalizing bias in individuals with first-episode schizophrenia-spectrum disorder and at-risk mental state: the differential roles of neurocognition and social anxiety
Authors: Tsui Harry Kam Hung , Liao Yingqi , Hsiao Janet , Suen Yi Nam , Yan Eric Wai Ching , Poon Lap-Tak , Siu Man Wah , Hui Christy Lai Ming , Chang Wing Chung , Lee Edwin Ho Ming , Chen Eric Yu Hai , Chan Sherry Kit Wa
Published: July 2024

Mentalizing, or theory of mind (ToM), impairments and self-referential hypermentalizing bias are well-evident in schizophrenia. However, findings compared to individuals with at-risk mental states (ARMS) are inconsistent, and investigations into the relationship between social cognitive impairments and social anxiety in the two populations are scarce. This study aimed to examine and compare these deficits in first-episode schizophrenia-spectrum disorder (FES) and ARMS, and to explore potential specific associations with neurocognition and symptomatology. Forty patients with FES, 40 individuals with ARMS, and 40 healthy controls (HC) completed clinical assessments, a battery of neurocognitive tasks, and three social cognitive tasks. The comic strip and hinting tasks were used to measure non-verbal and verbal mentalizing abilities, and the gaze perception task was employed to assess self-referential hypermentalizing bias. FES and ARMS showed comparable mentalizing impairments and self-referential hypermentalizing bias compared to HC. However, only ambiguous self-referential gaze perception (SRGP) bias remained significantly different between three groups after controlling for covariates. Findings suggested that self-referential hypermentalizing bias could be a specific deficit and may be considered a potential behavioral indicator in early-stage and prodromal psychosis. Moreover, working memory and social anxiety were related to the social cognitive impairments in ARMS, whereas higher-order executive functions and positive symptoms were associated with the impairments in FES. The current study indicates the presence of stage-specific mechanisms of mentalizing impairments and self-referential hypermentalizing bias, providing insights into the importance of personalized interventions to improve specific neurocognitive domains, social cognition, and clinical outcomes for FES and ARMS.
Fiberoptic Endoscopy Evaluation of Swallowing (FEES) Findings Associated with High Pneumonia Risk in a Cohort of Patients at Risk of Dysphagia
Authors: Giraldo-Cadavid Luis F. , Insignares Diego , Velasco Valentina , Londoño Natalia , Galvis Ana María , Rengifo María Leonor , Bastidas-Goyes Alirio R.
Published: July 2024

Aspiration detected in the fiberoptic endoscopy evaluation of swallowing (FEES) has been inconsistently associated with pneumonia, with no evidence of the risk of pneumonia from other alterations in swallowing safety detected in FEES. We conducted a dynamic, ambidirectional cohort study involving 148 subjects at risk of dysphagia in a tertiary university hospital. Our aim was to determine the risk of pneumonia attributed to alterations in swallowing safety detected during FEES. We used multivariate negative binomial regression models to adjust for potential confounders. The incidence density rate (IR) of pneumonia in patients with tracheal aspiration of any consistency was 26.6/100 people-years (RR 7.25; 95% CI: 3.50–14.98; P < 0.001). The IR was 19.7/100 people-years (RR 7.85; 95% CI: 3.34–18.47; P < 0.001) in those with laryngeal penetration of any consistency and 18.1/100 people-years (RR 6.24; 95% CI: 2.58–15.09; P < 0.001) in those with pharyngeal residue of any consistency. When adjusted for aspiration, the association of residue and penetration with pneumonia disappeared, suggesting that their risk of pneumonia is dependent on the presence of aspiration and that only aspiration is independently associated with pneumonia. This increased risk of pneumonia was significant in uni- and multivariate negative binomial regression models. We found an independently increased risk of pneumonia among patients with dysphagia and aspiration detected during FEES. Alterations in the oral and pharyngeal phases of swallowing, without aspiration, did not increase the risk of pneumonia.
Robotic hepaticojejunostomy training in novices using robotic simulation and dry-lab suturing (ROSIM): randomized controlled crossover trial
Authors: Menso Julia E. , Rahimi A. Masie , Zwart Maurice J. W. , Daams Freek , de Hondt Joey , Karadza Emir , Montorsi Roberto M. , Nickel Felix , Bonjer H. Jaap , van Dijkum Els J. M. Nieveen , Besselink Marc G.
Published: July 2024

Background

Robotic suturing training is in increasing demand and can be done using suture-pads or robotic simulation training. Robotic simulation is less cumbersome, whereas a robotic suture-pad approach could be more effective but is more costly. A training curriculum with crossover between both approaches may be a practical solution. However, studies assessing the impact of starting with robotic simulation or suture-pads in robotic suturing training are lacking.

Methods

This was a randomized controlled crossover trial conducted with 20 robotic novices from 3 countries who underwent robotic suturing training using an Intuitive Surgical® X and Xi system with the SimNow (robotic simulation) and suture-pads (dry-lab). Participants were randomized to start with robotic simulation (intervention group, n = 10) or suture-pads (control group, n = 10). After the first and second training, all participants completed a robotic hepaticojejunostomy (HJ) in biotissue. Primary endpoint was the objective structured assessment of technical skill (OSATS) score during HJ, scored by two blinded raters. Secondary endpoints were force measurements and a qualitative analysis. After training, participants were surveyed regarding their preferences.

Results

Overall, 20 robotic novices completed both training sessions and performed 40 robotic HJs. After both trainings, OSATS was scored higher in the robotic simulation-first group (3.3 ± 0.9 vs 2.5 ± 0.8; p = 0.049), whereas the median maximum force (N) (5.0 [3.2–8.0] vs 3.8 [2.3–12.8]; p = 0.739) did not differ significantly between the groups. In the survey, 17/20 (85%) participants recommended to include robotic simulation training, 14/20 (70%) participants preferred to start with robotic simulation, and 20/20 (100%) to include suture-pad training.

Conclusion

Surgical performance during robotic HJ in robotic novices was significantly better after robotic simulation-first training followed by suture-pad training. A robotic suturing curriculum including both robotic simulation and dry-lab suturing should ideally start with robotic simulation.
Evaluation of the environmental and economic scope of an electrocoagulation process for the treatment of wastewater from the instant coffee industry
Authors: Dobrosz-Gómez Izabela , Ibarra-Taquez Harold N. , Gómez-García Miguel-Ángel
Published: July 2024

In this study, an industrial wastewater from instant coffee production was treated by electrocoagulation (EC). The effect of various EC operating parameters, such as electrode type, current density, support electrolyte concentration and stirring velocity, were investigated to determine the optimal operating EC conditions. The scope of electrocoagulation (EC) was assessed, in environmental and economic terms, for the treatment of industrial wastewater originated from the production of instant coffee. The evaluation included the effect of EC operating factors (electrode type, current density, supporting electrolyte concentration and stirring velocity) on Color removal, COD and TOC degradation, toxicity, molecular weight distribution, as well as the total operating cost. The following optimal operating conditions were established through a series of preliminary experiments, a Box-Behnken design of experiments, Response Surface Methodology application, and multi-objective optimization analysis: the pair of Fe (anode)-stainless steel (cathode) electrodes, supporting electrolyte = 1.78 g of NaCl/L; current density = 150 A/m2; electrode gap = 3 mm; stirring velocity = 350 RPM; and pH0 = 4.7 (that of raw industrial effluent). Finally, the kinetic study allowed defining the electrolysis operation time of ca. 180 min required to comply with the maximum permissible discharge limits for the production of instant coffee the discharge of soluble coffee effluents, in terms of COD concentration, established by current Colombian legislation. The EC reached ca. 97% decolorization, as well as 72% and 65% of COD and TOC removal degradation, respectively, with total operating costs of 6.26 USD/m3. This yielded an oxidized (COS = 2.87), biocompatible (BOD5/COD = 0.437) and non-toxic effluent, free of contaminants with molecular weight > 30 kDa. The EC appeared as an effective alternative for the treatment of industrial wastewater from the production of instant coffee within the framework of different Sustainable Development Goals (number 6 (Clean water and sanitation), number 7 (Clean and affordable energy), number 9 (Industry, innovation and infrastructure) and 13 (Climate action)).
Exploring regulatory mechanisms on miRNAs and their implications in inflammation-related diseases
Authors: Nalbant Emre , Akkaya-Ulum Yeliz Z.
Published: July 2024

This comprehensive exploration delves into the pivotal role of microRNAs (miRNAs) within the intricate tapestry of cellular regulation. As potent orchestrators of gene expression, miRNAs exhibit diverse functions in cellular processes, extending their influence from the nucleus to the cytoplasm. The complex journey of miRNA biogenesis, involving transcription, processing, and integration into the RNA-induced silencing complex, showcases their versatility. In the cytoplasm, mature miRNAs finely tune cellular functions by modulating target mRNA expression, while their reach extends into the nucleus, influencing transcriptional regulation and epigenetic modifications. Dysregulation of miRNAs becomes apparent in various pathologies, such as cancer, autoimmune diseases, and inflammatory conditions. The adaptability of miRNAs to environmental signals, interactions with transcription factors, and involvement in intricate regulatory networks underscore their significance. DNA methylation and histone modifications adds depth to understanding the dynamic regulation of miRNAs. Mechanisms like competition with RNA-binding proteins, sponging, and the control of miRNA levels through degradation and editing contribute to this complex regulation process. In this review, we mainly focus on how dysregulation of miRNA expression can be related with skin-related autoimmune and autoinflammatory diseases, arthritis, cardiovascular diseases, inflammatory bowel disease, autoimmune and autoinflammatory diseases, and neurodegenerative disorders. We also emphasize the multifaceted roles of miRNAs, urging continued research to unravel their complexities. The mechanisms governing miRNA functions promise advancements in therapeutic interventions and enhanced insights into cellular dynamics in health and disease.
Impact of antiphospholipid antibodies on cardiac valve lesions in systemic lupus erythematosus: a systematic review and meta-analysis
Authors: Chen Siyun , Zhou Yangzhong , Wang Chuhan , Jiang Hui , Zhao Yuan , Zhao Jiuliang , Huang Can , Li Mengtao , Zhao Yan
Published: July 2024

This meta-analysis assesses antiphospholipid antibodies’ (aPLs) impact on heart valve disease in Systemic Lupus Erythematosus (SLE) patients. We searched PubMed, Embase, Cochrane, and Web of Science up to January 2024 for comparative studies of heart valve disease in aPL-positive versus aPL-negative SLE patients. Fixed-effect or random-effect models were used to synthesize data, with I2 and sensitivity analyses for heterogeneity and the trim-and-fill method for publication bias. Including 25 studies with 8089 patients, of which 919 had valvular changes, aPLs significantly increased the risk of heart valve disease (OR = 2.24, 95% CI: 1.58–3.18, p < 0.001). Lupus anticoagulant (LA) indicated the highest risk (OR = 4.90, 95% CI: 2.26–10.60, p < 0.001), anticardiolipin antibodies (aCL) doubled the risk (OR = 2.69, 95% CI: 1.47–4.93, p = 0.001), and anti-β2 glycoprotein I (aβ2GPI) showed a 70% increase (OR = 1.70, 95% CI: 1.17–2.45, p = 0.005). Valve-specific analysis indicated the mitral valve was most commonly involved (26.89%), with higher occurrences in aPL-positive patients (33.34% vs. 15.92%, p = 0.053). Aortic and tricuspid valve involvements were 13.11% vs. 5.42% (p = 0.147) and 12.03% vs. 8.52% (p = 0.039), respectively. Pulmonary valve disease was rare and similar across groups (1.01% in aPL-positive vs. 1.52% in aPL-negative). Significantly, only tricuspid valve disease showed increased risk in aPL-positive patients (OR = 2.66, 95% CI: 1.05–6.75, p = 0.039). APLs notably increase the risk of heart valve disease in SLE patients, with a pronounced effect on tricuspid valve involvement. Regular cardiac assessments for aPL-positive SLE patients are crucial for timely intervention and improved prognosis.
miR-708-3p targetedly regulates LSD1 to promote osteoblast differentiation of hPDLSCs in periodontitis
Authors: Shao Qing , Liu ShiWei , Zou Chen , Ai YiLong
Published: July 2024

Periodontitis (PD) is a multifactorial inflammatory disease associated with periodontopathic bacteria. Lysine-specific demethylase 1 (LSD1), a type of histone demethylase, has been implicated in the modulation of the inflammatory response process in oral diseases by binding to miRNA targets. This study investigates the molecular mechanisms by which miRNA binds to LSD1 and its subsequent effect on osteogenic differentiation. First, human periodontal ligament stem cells (hPDLSCs) were isolated, cultured, and characterized. These cells were then subjected to lipopolysaccharide (LPS) treatment to induce inflammation, after which osteogenic differentiation was initiated. qPCR and western blot were employed to monitor changes in LSD1 expression. Subsequently, LSD1 was silenced in hPDLSCs to evaluate its impact on osteogenic differentiation. Through bioinformatics and dual luciferase reporter assay, miR-708-3p was predicted and confirmed as a target miRNA of LSD1. Subsequently, miR-708-3p expression was assessed, and its role in hPDLSCs in PD was evaluated through overexpression. Using chromatin immunoprecipitation (ChIP) and western blot assay, we explored the potential regulation of osterix (OSX) transcription by miR-708-3p and LSD1 via di-methylated H3K4 (H3K4me2). Finally, we investigated the role of OSX in hPDLSCs. Following LPS treatment of hPDLSCs, the expression of LSD1 increased, but this trend was reversed upon the induction of osteogenic differentiation. Silencing LSD1 strengthened the osteogenic differentiation of hPDLSCs. miR-708-3p was found to directly bind to and negatively regulate LSD1, leading to the repression of OSX transcription through demethylation of H3K4me2. Moreover, overexpression of miR-708-3p was found to promote hPDLSCs osteogenic differentiation in inflammatory microenvironment. However, the protective effect was partially attenuated by reduced expression of OSX. Our findings indicate that miR-708-3p targetedly regulates LSD1 to enhance OSX transcription via H3K4me2 methylation, ultimately promoting hPDLSCs osteogenic differentiation.
OpenHands: An Open-Source Statistical Shape Model of the Finger Bones
Authors: Munyebvu T. A. , Metcalf C. D. , Burson-Thomas C. B. , Warwick D. , Everitt C. , King L. , Darekar A. , Browne M. , Heller M. O. W. , Dickinson A. S.
Published: July 2024

This paper presents statistical shape models of the four fingers of the hand, with an emphasis on anatomic analysis of the proximal and distal interphalangeal joints. A multi-body statistical shape modelling pipeline was implemented on an exemplar training dataset of computed tomography (CT) scans of 10 right hands (5F:5M, 27–37 years, free from disease or injury) imaged at 0.3 mm resolution, segmented, meshed and aligned. Model generated included pose neutralisation to remove joint angle variation during imaging. Repositioning was successful; no joint flexion variation was observed in the resulting model. The first principal component (PC) of morphological variation represented phalanx size in all fingers. Subsequent PCs showed variation in position along the palmar-dorsal axis, and bone breadth: length ratio. Finally, the models were interrogated to provide gross measures of bone lengths and joint spaces. These models have been published for open use to support wider community efforts in hand biomechanical analysis, providing bony anatomy descriptions whilst preserving the security of the underlying imaging data and privacy of the participants. The model describes a small, homogeneous population, and assumptions cannot be made about how it represents individuals outside the training dataset. However, it supplements anthropometric datasets with additional shape information, and may be useful for investigating factors such as joint morphology and design of hand-interfacing devices and products. The model has been shared as an open-source repository (https://github.com/abel-research/OpenHands), and we encourage the community to use and contribute to it.
Label-Free Monitoring of Endometrial Cancer Progression Using Multiphoton Microscopy
Authors: Wu Xuzhen , Kong Yanqing , Yi Yu , Xu Shuoyu , Chen Jianhua , Chen Jianxin , Jin Ping
Published: July 2024

Endometrial cancer is the most common gynecological cancer in the developed world. However, the accuracy of current diagnostic methods is still unsatisfactory and time-consuming. Here, we presented an alternate approach to monitoring the progression of endometrial cancer via multiphoton microscopy imaging and analysis of collagen, which is often overlooked in current endometrial cancer diagnosis protocols but can offer a crucial signature in cancer biology. Multiphoton microscopy (MPM) based on the second-harmonic generation and two-photon excited fluorescence was introduced to visualize the microenvironment of endometrium in normal, hyperplasia without atypia, atypical hyperplasia, and endometrial cancer specimens. Furthermore, automatic image analysis based on the MPM image processing algorithm was used to quantify the differences in the collagen morphological features among them. MPM enables the visualization of the morphological details and alterations of the glands in the development process of endometrial cancer, including irregular changes in the structure of the gland, increased ratio of the gland to the interstitium, and atypical changes in the glandular epithelial cells. Moreover, the destructed basement membrane caused by gland proliferation and fusion is clearly shown in SHG images, which is a key feature for identifying endometrial cancer progression. Quantitative analysis reveals that the formation of endometrial cancer is accompanied by an increase in collagen fiber length and width, a progressive linearization and loosening of interstitial collagen, and a more random arrangement of interstitial collagen. Observation and quantitative analysis of interstitial collagen provide invaluable information in monitoring the progression of endometrial cancer. Label-free multiphoton imaging reported here has the potential to become an in situ histological tool for effective and accurate early diagnosis and detection of malignant lesions in endometrial cancer.
Beyond the echo chamber: modelling open-mindedness in citizens’ assemblies
Authors: Barrett Jake , Gal Kobi , Michael Loizos , Vilenchik Dan
Published: July 2024

A Citizens’ assembly (CA) is a democratic innovation tool where a randomly selected group of citizens deliberate a topic over multiple rounds to generate, and then vote upon, policy recommendations. Despite growing popularity, little work exists on understanding how CA inputs, such as the expert selection process and the mixing method used for discussion groups, affect results. In this work, we model CA deliberation and opinion change as a multi-agent systems problem. We introduce and formalise a set of criteria for evaluating successful CAs using insight from previous CA trials and theoretical results. Although real-world trials meet these criteria, we show that finding a model that does so is non-trivial; through simulations and theoretical arguments, we show that established opinion change models fail at least one of these criteria. We therefore propose an augmented opinion change model with a latent ‘open-mindedness’ variable, which sufficiently captures people’s propensity to change opinion. We show that data from the CA of Scotland indicates a latent variable both exists and resembles the concept of open-mindedness in the literature. We calibrate parameters against real CA data, demonstrating our model’s ecological validity, before running simulations across a range of realistic global parameters, with each simulation satisfying our criteria. Specifically, simulations meet criteria regardless of expert selection, expert ordering, participant extremism, and sub-optimal participant grouping, which has ramifications for optimised algorithmic approaches in the computational CA space.
Prevalence of Sexual Strangulation/Choking Among Australian 18–35 Year-Olds
Authors: Sharman Leah S. , Fitzgerald Robin , Douglas Heather
Published: July 2024

In Australia, strangulation has been explicitly criminalized in all states and territories. However, it continues to be a “normalized” sexual practice despite its potentially fatal consequences and associated short and long-term sequelae. This research aimed to establish the prevalence of strangulation during sex and examine predictors of positive perceptions toward sexual strangulation in Australia. Confidential, cross-sectional online surveys were conducted with 4702 Australians aged 18–35 years. Participants were 47% cis-men, 48% cis-women, and 4% trans or gender diverse. A total of 57% reported ever being sexually strangled (61% women, 43% men, 79% trans or gender diverse) and 51% reported ever strangling a partner (40% women, 59% men, 74% trans or gender diverse). Differences were found across genders on all variables of sexual strangulation, including frequency of engagement, level of pressure on the neck, consequences, wanting and enjoyment, and how consent was given/received. However, when split by gender, sexual orientation of men and women revealed further differences in behaviors, consequences, and wanting, particularly among straight and bisexual women. After accounting for exposure to strangulation in pornography and previous experience of sexual strangulation, positive perceptions of being strangled (R
2 = .51) and strangling a partner (R
2 = .53) were predicted by ratings that it could be done safely and social normative factors. These findings suggest strangulation is common during sex among young Australians. Non-stigmatizing education strategies are needed to engage with young people so they have a better understanding of the risks involved and how to negotiate consent and safety regarding sexual strangulation.
Microwave ablation followed by cTACE in 5-cm HCC lesions: does a single-session approach affect liver function?
Authors: Floridi Chiara , Cacioppa Laura Maria , Rossini Nicolò , Macchini Marco , Bruno Alessandra , Agostini Andrea , Consoli Valeria , Inchingolo Riccardo , Acquafredda Fabrizio , Nicolini Daniele , Schiadà Laura , Svegliati Baroni Gianluca , Candelari Roberto
Published: July 2024

Purpose

Microwave ablation (MWA) and conventional transarterial chemoembolization (cTACE) are locoregional treatments commonly performed in very early, early and intermediate stages of hepatocellular carcinoma (HCC). Despite combined locoregional approaches have shown encouraging results in obtaining complete tumor necrosis, their application in a single session is poorly described.

Our aim was to evaluate the safety and efficacy of single-session MWA and cTACE treatment in 5-cm HCCs and its influence on liver function.

Materials and methods

All 5-cm HCCs treated by MWA and cTACE performed in a single-session in our Interventional Radiology unit between January 2020 and December 2022 were retrospectively recorded and analyzed. Patients with poor or missing pre- and post-treatment imaging were excluded. Technical success, clinical success, and complications rate were examined as primary endpoints. Pre- and post-treatment liver function laboratory parameters were also evaluated.

Results

A total of 15 lesions (mean lesion diameter, 5.0 ± 1.4 cm) in 15 patients (11 men; mean age, 67.1 ± 8.9 years) were retrospectively evaluated. Technical and clinical success were 100% and 73%, respectively. Four (27%) cases of partial response and no cases of progressive or stable disease were recorded. AST and ALT values have found to be significantly higher in post-treatment laboratory tests. No other significant differences between pre- and post-treatment laboratory values were registered. AST and ALT pre- and post-treatment higher differences (ΔAST and ΔALT) were significantly associated with a lower clinical success rate.

Conclusion

MWA and cTACE single-session approach is safe and effective for 5-cm HCCs, without significant liver function impairment. A post-treatment increase in AST and ALT values may be a predictor for clinical failure.
Implementation of an intelligent process monitoring system for screw presses using the CRISP-DM standard
Authors: Doede Nils , Merkel Paulina , Kriwall Mareile , Stonis Malte , Behrens Bernd-Arno
Published: July 2024

Increasing the service life and process reliability of systems plays an important role in terms of sustainable and economical production. Especially in the field of energy-intensive bulk forming, low scrap rates and long tool lifetimes are business critical. This article describes a modular method for AI-supported process monitoring during hot forming within a screw press. With this method, the following deviations can be detected in an integrated process: the height of the semi-finished product, the positions of the die and the position of the semi-finished product. The method was developed using the CRISP-DM standard. A modular sensor concept was developed that can be used for different screw presses and dies. Subsequently a hot forming-optimized test plan was developed to examine individual and overlapping process deviations. By applying various methods of artificial intelligence, a method for process-integrated detection of process deviations was developed. The results of the investigation show the potential of the developed method and offer starting points for the investigation of further process parameters.