bluuebunny/crossref_metadata_2025 huggingface dataset:
The Role of Gut Microbiota in Food Digestion and Its Implications for Human Health
Authors: Editor8 Section
Published: April 2024

Purpose: The general aim of this study was to examine the role of gut microbiota in food digestion and its implications for human health.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to the role of gut microbiota in food digestion. Preliminary empirical review revealed that gut microbial communities play a dynamic role in modulating nutrient metabolism, immune function, and overall digestive wellness. Through diverse empirical investigations, it was revealed that gut microbiota composition is influenced by factors such as diet, lifestyle, and host genetics, with dysbiosis linked to immune-mediated gastrointestinal disorders. Moreover, dietary interventions and lifestyle modifications were identified as effective strategies for modulating gut microbiota composition and function, offering promising avenues for promoting digestive health. Overall, this research provided valuable insights into the complex interactions between gut microbiota and host physiology, paving the way for personalized therapeutic interventions to optimize digestive function and mitigate gastrointestinal disorders.
Unique Contribution to Theory, Practice and Policy: The Ecological theory of Gut Microbiota, Metabolic theory of Gut Microbiota and Immunological theory of Gut Microbiota may be used to anchor future studies on the role of gut microbiota in digestion and its impacts on human health. The study provided recommendations that contributed to theory, practice, and policy in microbiome research and public health. It suggested further exploration of ecological theory to understand the dynamic interactions between gut microbiota and food digestion, leading to advancements in theoretical frameworks. Practically, the study emphasized personalized nutrition interventions based on gut microbiota composition to optimize digestive health, while policy recommendations included integrating microbial research into public health initiatives and fostering interdisciplinary collaboration. These recommendations aimed to translate microbiome science into actionable strategies for improving digestive health outcomes and enhancing overall well-being.
Assessment of the Environmental Footprint of Various Food Production Systems
Authors: Shalom Donny
Published: April 2024

Purpose: This study sought to assess the environmental footprint of various food production systems.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to the environmental footprint of various food production systems. Preliminary empirical review revealed that with a call for transformative changes to mitigate ecological impacts while ensuring food security and human well-being. Through a comprehensive analysis, significant variations in resource use and emissions were highlighted across different production methods. The study emphasized the interconnectedness between dietary choices, agricultural practices, and environmental outcomes, urging policymakers to enact evidence-based policies and agricultural stakeholders to adopt regenerative farming practices. Ultimately, the study served as a call to action for concerted efforts to transition towards a more sustainable and resilient food system, integrating ecological principles, social equity, and economic viability to promote harmony between human activities and the natural environment.
Unique Contribution to Theory, Practice and Policy: The Systems theory, Ecological Economics and Agroecology models may be used to anchor future studies on the environmental footprint of various food production systems. The study made significant contributions to theory, practice, and policy in the realm of sustainable food production and environmental conservation. It advanced theoretical understanding by advocating for a systems-based approach to assessing environmental impacts and highlighting the importance of considering multiple dimensions of sustainability. In practice, the study recommended the adoption of agroecological approaches and the promotion of sustainable farming practices to mitigate environmental harm. Policy recommendations included the implementation of regulatory interventions and incentives to promote sustainability, while consumer education and international collaboration were emphasized for driving demand for sustainable food products and facilitating knowledge sharing. Lastly, the study underscored the importance of investment in research and innovation to drive continuous improvements in sustainable food production systems.
Role of Probiotic Strains in Ensuring Food Safety
Authors: Kisa Jeniffer
Published: April 2024

Purpose: The general objective of this study was to examine the role of probiotic strains in ensuring food safety.
Methodology: The study adopted a desktop research methodology. Desk research refers to secondary data or that which can be collected without fieldwork. Desk research is basically involved in collecting data from existing resources hence it is often considered a low cost technique as compared to field research, as the main cost is involved in executive’s time, telephone charges and directories. Thus, the study relied on already published studies, reports and statistics. This secondary data was easily accessed through the online journals and library.
Findings: The findings reveal that there exists a contextual and methodological gap relating to the role of probiotic strains in ensuring food safety. Preliminary empirical review revealed that that probiotics offer promising avenues for enhancing microbial safety in food products. Through a comprehensive review of existing literature and empirical studies, researchers found that probiotics exhibited varied but significant antimicrobial activity against foodborne pathogens, thus reducing the risk of foodborne illnesses. The study emphasized the importance of strain-specific evaluation and standardized protocols for assessing probiotic efficacy. Furthermore, interdisciplinary collaborations were identified as crucial for translating scientific findings into practical applications for public health. Overall, the study highlighted the significant potential of probiotic strains in improving food safety outcomes, with further research needed to optimize formulations and address knowledge gaps.
Unique Contribution to Theory, Practice and Policy: Ecological Theory of Gut Microbiota, Host-Microbiota Mutualism theory and Systems Biology Approach to Gut Microbiome may be used to anchor future studies on probiotic strains in ensuring food safety. The study emphasized advancing understanding of microbial ecology in the gastrointestinal tract, developing evidence-based guidelines for probiotic use, and aligning policies with scientific evidence. Recommendations included investing in research and education initiatives, fostering interdisciplinary collaborations, and promoting international cooperation. By integrating ecological principles, developing standardized protocols, and aligning policies with scientific evidence, stakeholders were able to harness the potential of probiotics to enhance food safety and public health, ultimately benefiting consumers worldwide.
THE EFFECT OF INFLATION, EXPORT-IMPORT AND INTEREST RATES ON SALES THROUGH GDP/GDP MODERATION VARIABLES
Authors: Akbar Taufik -
Published: April 2024

This study aims to determine the effect of inflation, export-import, interest rates on sales in state-owned pharmaceutical holding companies with moderating variables of Gross Domestic Product (GDP). The type of research used is quantitative with primary and secondary data sources related to inflation, export-import, interest rates, GDP and sales. The data used is a combination of time series data for 2018-2022 and cross-section which is then referred to as panel data. The study was also conducted in more depth using a research instrument in the form of a questionnaire with respondents as many as six people who had positions as department heads in the parent company of Pharmaceutical SOEs. Data analysis techniques use multiple linear regression analysis and Moderating Regression Analysis. The results showed that simultaneously the variables of inflation, export-import and interest rates had a positive and significant effect on sales. Meanwhile, the moderation variable, namely GDP, partially affects sales, but cannot moderate the influence of inflation and export-import both in terms of strengthening and weakening the influence of the independent variable on the dependent variable. Other research results show GDP can be a pure moderator of the influence of interest rates on sales. This research has limitations, namely the variables used are macro, therefore for future research it is expected to be able to conduct research using micro variables in the economy. 
 
Keywords: Inflation, Export-Import, Interest Rate, GDP, Sales and Holding Company of SOEs.
Assessing the Status of Flood Hazard on the Bank of Mohana River in Kailari Rural Municipality
Authors: Shah Sanjay , Mishra A. K. , Aithal P. S.
Published: April 2024

Purpose: Kailali holds number of rivers originating from Mahabharat range and Chure range which get flooded every year, causing high losses of agricultural land and the flooding at community level. In order to identify and understand the probable risks in the study area and the methodologies followed to get rid of the flood risk or to protect the land and community from the effect of flood.
Design/Methodology/Approach: The study was conducted during the period from March 2022 to May 2023. Field observation, in-depth interview, focus group discussion and questionnaire survey were the major tool applied for the investigation.
Findings/Results: The study found that the flood is the major hazard, and the earthquake is the minor one. River encroachment is the major one problem of the river training works and inadequate people’s awareness is the minor one. The river down to Chure carries lots of sediment and thus increasing the bed loads. Thus, Chure protection programs must be effectively executed so that the lower plain will be sediment less and the inundation of land will be reduced.
Originality/Value: The paper contributes on the effective ways to protect community from flood hazards
LITERATURE REVIEW: THE INFLUENCE OF SELF-MANAGEMENT AND STRESS MANAGEMENT IN IMPROVING EMPLOYEE PERFORMANCE IN COMPANIES
Authors: Mayasari Eka , Hasanah Faidatul , Suhartini Dwi
Published: April 2024

This research aims to explore and reveal the importance of the influence of self-management and stress management in improving employee performance in companies or agencies. The research method uses a literature review approach, by collecting 15 journal articles from 2017-2023 from Google Scholar. The results of this research reveal the positive impact of self-management in achieving work goals, conflict management, and improving employee quality of life. Apart from that, the concept of stress management is an important key in living a balanced and healthy life in a world full of challenges. Stress is a natural response to pressure and demands routine life, but if not managed carefully, it can have detrimental impacts on a person's physical and mental well-being as well as an important basis for improving the work environment and employee welfare, which can increase productivity and performance. The research contribution can explain that the more stress management increases, the impact it will have on increasing employee performance. For this reason, there needs to be a balance between soft skills and hard skills. This research has limitations, namely the small number of journals reviewed due to the limited number of relevant topics.
Globalization and Economic Growth in Nigeria
Authors: Jaho Philip , Ohale Lawrence , Obayori Joseph
Published: April 2024

The study examined globalization and economic growth in Nigeria from 1985 to 2021. The objectives of the study are to; determine the impact of financial openness on economic growth in Nigeria; examine the effect of the net exports on economic growth in Nigeria; and examine the impact of exchange rate on economic growth in Nigeria. Annual data was collected from Central Bank of Nigeria statistical bulletins and World Development Index. The technique of Autoregressive Distributed Lag (ARDL) model was used to analyze the data. The empirical results showed that in the long run, all the variables of globalization have positive and significant relationship with economic growth in Nigeria during the period of study. In the short run, both financial openness and exchange rate have positive relationship with economic growth in Nigeria. But net exports have negative impact on economic growth in Nigeria. Based on these findings, it was concluded that, to a great extent economic globalization significantly accelerate economic growth in the longrun in the Nigerian economy. Based on these findings, it was recommended that, there should be creation of conducive environment to encourage openness of trade through inflow of investment that will trigger economic growth. Similarly, depreciation of the exchange rate which is an indicator of global price could be an obvious instrument that helps to drive the growth process in the Nigerian economy.
The Question of Diplomatic Immunity and Privileges in International Law: The D.S.P Alamieyeseigh Experience
Authors: Kalama John , Odon Grace , Prince Frank , Odu Queen
Published: April 2024

The complex nature of the international system prompted states to adopt treaties, laws and conventions to facilitates peaceful international relations and mutual co-existence hence, this paper examined the relevance of these treaties, laws, rules and conventions especially as it relates to diplomatic immunity and who is qualified to enjoy such diplomatic immunity in contemporary international law. The study observed that elected state governors in Nigeria are entitled to diplomatic immunity as reflected in section 308 of the constitution of the federal republic of Nigeria 1999 as amended. Further findings also revealed that the arrest, detention and trial of D.S.P. Alamieyeseigha in London by the British government violated the provisions of the 1961 Vienna Convention on Diplomatic Relations, 1963 Vienna Convention on Consular Relations and the 1973 Convention on the Prevention and Punishment of Crimes against Internationally Protected Persons including diplomatic agents. Data for the study were drawn from secondary sources while analysis was done descriptively through the qualitative method. In other to strengthen international law and regulate the actions of states and leaders at the global level, state legislatures, national parliaments and agencies of government including the judiciary should be empowered to moderate and check the actions of state governors, president's and other category of political leaders. This will ensure that personal actions and acts are not misrepresented as acts of state/government at all levels.
On the Effects of Deep Cryogenic Treatment on Wear Resistance, Hardness and Microstructure of the AISI D2 and D3 Tool Steel
Authors: Ashok D. Wale
Published: April 2024

The present study investigates the effect of cryogenic treatment on AISI D2 and D3 tool steels. This analysis is carried out for several heat treatment cycles that follow various tempering and cryoprocessing sequences that are not analysed erstwhile. Moreover, the effect of these heat treatment cycles on wear characteristics, hardness, and microstructural features of AISI D2 and D3 tool steel is also analysed. It is demonstrated that the cryogenic treatment significantly improves the wear resistance, hardness, and retained austenitic transformation of both types of material specimens under consideration. Furthermore, it is established that single tempering after cryogenic treatment is more effective than double tempering processes carried out in different sequences. It is also revealed that the double tempering sequencing involving cryoprocessing stalls the transformation of retained austenite, leading to higher wear and low hardness in the material
Machine Learning-Based Sales Prediction and Inventory Management for Grocery Stores
Authors: Prof. Shital Shende  , Ayush Namdeo
Published: April 2024

In today's competitive grocery retail environment, effective inventory management coupled with precise sales prediction is pivotal for success. This research undertakes an in-depth exploration into a machine learning framework tailored for "Sales Forecasting and Inventory Optimization in Grocery Retail." Utilizing historical sales records, meteorological data, and consumer behavior metrics, the proposed model endeavors to predict nuanced seasonal demand fluctuations. The primary value proposition of this approach lies in its capacity to curtail wastage, ensuring the balance between overstocking and inventory stockouts. By recognizing and adjusting for seasonal dynamics, the system offers enhanced demand fulfillment during high-demand periods. The subsequent refinement of the replenishment cycle fosters superior operational efficacy. As an outcome, businesses witness cost reductions, augmented profit margins, and elevated consumer contentment due to consistent product availability. As the broader grocery sector undergoes transformation, embedding sophisticated machine learning strategies can be a linchpin for sustained adaptability and competitiveness. This research further underscores the role of emergent technologies, such as machine learning within the IoT spectrum, in reshaping supply chain and communication paradigms. The endeavor here is to curtail lifecycle expenses in the supply chain by refining inventory practices. The research introduces a Deep Inventory Management (DIM) technique, employing the LSTM paradigm of deep learning. Through DIM's innovative approach, time-series challenges are reimagined as supervised learning tasks, enabling efficient model training. Preliminary tests indicate DIM's prediction accuracy hovers around 80%, translating to an impressive 25% reduction in inventory expenses when juxtaposed with prevailing methods, alongside rapid anomaly detection in inventory activities
RESPUESTA DEL MAÍZ A LA APLICACIÓN DE DIFERENTES DOSIS DE NITRÓGENO EN ROTACIÓN CON KUDZÚ Pueraria phaseoloides, BAJO DOS TIPOS DE LABRANZA.
Authors: Polo Ledezma Edgar Alexis , Urieta Sebastián , Moreno Yaliska
Published: April 2024

Se realizó un experimento para evaluar la respuesta del maíz a cinco dosis de nitrógeno (0, 50, 100, 150 y 200 kg/ha) en forma de urea, bajo el sistema de siembra en rotación con la leguminosa Kudzú (Pueraria phaseoloides), en dos tipos de labranzas. Se utilizó el diseño experimental de parcelas subdivididas (labranza * dosis de nitrógeno).  En la parcela principal se evaluaron las labranzas (conservación y convencional) y en las subparcelas las dosis de nitrógeno.  Las parcelas estaban arregladas en bloques completos al azar con tres repeticiones. En las parcelas con labranza de conservación la leguminosa y algunas malezas presentes se cortaron y dejaron sobre la parcela; mientras que en las parcelas con labranza convencional, se cortó toda la parte vegetativa de la planta de kudzú y se incorporó en el suelo, con tres pases de monocultivador. Se encontró respuesta altamente significativa para el rendimiento de maíz, por el rendimiento de maíz, por el efecto residual de kudzu.  Los rendimientos de maíz en las parcelas donde se utilizó el kudzu como cobertura fueron de 4.6 ton/ha; mientras que en las parcelas donde se incorporó el kudzu solo hubo 3.6 ton/ha. La respuesta en rendimiento del maíz a la aplicación de nitrógeno también resulto altamente significativa, para los niveles 0, 50, 100, 150 y 200 kg de N/ha respectivamente.  El rendimiento promedio de maíz disminuyó cuando se paso del nivel 150 a 200 kg de N/ha.
INFLUENCIA DEL ENTORNO
Authors: Sumner Seirian , Hurtado Yow Javier
Published: April 2024

Un equipo de biólogos, liderado por la Profesora Seirian Sumner, una científica británica de University College London (Reino Unido), cuyo interés radica en la evolución molecular y los insectos sociales, completó un estudio de avispas, con la asistencia en campo del Profesor Javier Hurtado Yow, docente de la Universidad de Panamá. Se trata de un proyecto que involucra a la avispa tropical primitiva Polistes canadensis, de color marrón rojizo y se le conoce comúnmente como avispa de papel o chagreña, que muestra un comportamiento altruista entre su familia, como una estrategia para maximizar la aptitud física y sobrevivencia.
En este artículo de opinión se describen aspectos generales del proyecto Nest Drifting en Punta Galeta, con los aportes de los científicos asociados al mismo, Dra. Solenn Patalano, Dr. Thibault Lengronne y Dra. Emily Bell, destacando su trascendental contribución a través de todas las referencias bibliográficas aquí citadas. Desde la ejecución del trabajo en campo, hasta los hallazgos de la investigación en el presente, se ha utilizado la información como un aporte académico importante en la estrategia metodológica del proceso de enseñanza y aprendizaje de los estudiantes participantes de los cursos del Profesor Javier Hurtado Yow, sobre Ecología General, Ecología de Ecosistemas, Ecología de Poblaciones, entre otros, pertenecientes a la malla curricular de la Licenciatura en Biología con orientación en Biología Ambiental, de la Escuela de Biología del Centro Regional Universitario de Colón de la Universidad de Panamá.
Initial findings on student progress and satisfaction in a new model of hyperflexible online delivery for university students
Authors: Beer Colin , Ames Kate , Atkinson Noal , Clark Damien , Hosie Peter
Published: April 2024

University degrees are usually delivered in defined sessions —by term, semester, or in week-based blocks— whereby students are required to complete their studies by the due date. Term or session-based schedules that require students to complete the study within set timeframes are, however, potentially restrictive. Temporal challenges associated with work and life can impede progress and add to the specific problem of student attrition in online learning. As universities seek to deliver innovative options for their students, increased attention is being paid to alternate models of delivery. This paper reports on the development of a hyperflexible online Master of Business Administration (MBA) course by a regional university in Australia, which has grown to more than 1,000 students since its launch in 2017. Delivered entirely online, the degree was specifically designed to address an inequity; MBA programs are traditionally expensive, and in Australia, the requirement for students to travel to attend residential schools and examinations adds significant cost to already expensive tuition fees. This paper analyzed enrollment data, course analytics over a two-year period, and student surveys conducted at the end of the second year of delivery (n = 98) to evaluate the development and implementation of the course as a hyperflexible course whereby students have almost complete control over their study at the postgraduate tertiary level. Results highlight the potential for the model to enable student success through flexibility.
What hospitality and tourism higher educators learned from COVID-19: A case of Turkiye
Authors: Collins Ayse , Dulger Ayse , Tuna Muharrem , Uysal Muzaffer
Published: April 2024

Among all the sectors, the hospitality and tourism sector has been detrimentally affected by the impact of the COVID-19 pandemic. This research aimed to determine how changes have been experienced specifically in the Turkish tourism higher education and tourism sector. Twenty-seven academics from the hospitality and tourism education departments were interviewed. Most agreed that restrictions have limited student access to hands-on practical courses and internships, which are crucial to developing necessary competencies. Moreover, the results showed the curriculum does not always meet the needs of the hospitality industry for a trained and skilled workforce. The challenge is to decide what else should be taught and what methods and teaching approaches should be used. As a result, industry-academia cooperation is necessary to reassess the curriculum programs to meet sector needs considering the pandemic impacts.
Determining students’ personality traits according to parental perspectives: A scale development study
Authors: Aglar Cengiz , Dilci Tuncay
Published: April 2024

The educational community recognizes individual differences, but it is important to fully address them in educational settings. While there are existing studies on personality traits, none focus on the personality traits of students aged 6-18. This study aims to fill this gap, as personality traits significantly influence personal, academic, and professional life. Understanding student personalities allows for the development of more effective educational programs, facilitating their full potential. The study included parents of 2,229 students from a population of 16,505,271 aged 6-18 in Turkiye. Through exploratory factor analysis (EFA), a reliable 61-item 5-point Likert scale (α = .942) was derived. Confirmatory factor analysis (CFA) was performed on a second dataset of 916 parents, resulting in 794 due to outliers. The Scale for Determining Student Personalities According to Parental Perspectives, with 16 sub-dimensions and 46 items, demonstrated good reliability (α = .948). The study’s findings are expected to hold significant implications for education, parenting, and child development.
Financial characteristics of mobile banking and payment users in the United States
Authors: Mitchell Jordan , Li Xiao , Steel Doug , Decker Phillip
Published: April 2024

This study aims to examine the personal finance characteristics of mobile banking and mobile payment users in the United States. To achieve this goal, we used the 2018 National Financial Capability Study, which surveyed over 27,000 American adults regarding their personal financial standing and behaviors. By using ordinary least squares models, our results indicated that the use of mobile banking and mobile payment technology was associated with lower age, Non-White Ethnicity, higher income, higher debt load, debt types (auto, student, credit card, and predatory), and spending more than one’s income. These results reveal that the higher one’s income, financial liabilities, and spending are, the more they may value the convenience of mobile banking and payments.
Downregulation of circ_0119412 expression inhibits malignant progression of breast cancer by targeting the miR-1205/GALNT6 pathway in vivo and in vitro
Authors: Liu Jianhua , Du Qiuli , Yang Yong
Published: April 2024

Introduction

Aberrant circular RNA (circRNA) expression is associated with development of breast cancer. In this study, we aimed to assess the anti-proliferative effect of circ_0119412 knockdown on breast cancer cells.

Material and methods

Tumor and adjacent normal tissues were collected from 35 patients with invasive breast cancer (mean age: 56 years; mean tumor size: 2 cm; 46% patients with TNM I and II stages). The levels of circ_0119412, microRNA (miR)-1205, and N-acetylgalactosaminyltransferase 6 (GALNT6) were determined using reverse transcription-quantitative polymerase chain reaction. Cell proliferation and invasion were assessed using cell counting kit-8 and transwell assays, respectively. Cell apoptosis was assessed using flow cytometry. Moreover, the targeting relationships of miR-1205 with circ_0119412 and GALNT6 were determined using dual-luciferase reporter and RNA immunoprecipitation assays. Furthermore, tumor growth was observed in an animal model in vivo.

Results

We found that circ_0119412 expression levels were upregulated in breast cancer tumor specimens and cell lines. Downregulation of circ _0119412 inhibited the invasion and proliferation, while enhancing the apoptosis of breast cancer cells. Furthermore, circ_0119412 knockdown suppressed tumor growth in vivo. Notably, miR-1205 was identified as a downstream target of circ_0119412. Downregulation of circ_0119412 suppressed the aggressive behavior of breast cancer cells by targeting miR-1205. Moreover, GALNT6 was the downstream target of miR-1205. Inhibition of miR-1205 aggravated the malignant behavior of breast cancer cells by increasing GALNT6 expression.

Conclusions

Our findings suggest that the downregulation of circ_0119412 inhibits breast cancer progression, at least in part, by targeting the miR-1205/GALNT6 pathway.
LncRNA NEAT1 contributes to multiple myeloma progression via upregulating ARPC5 by sponging miR-133a
Authors: Wang Fujue , Zeng Piaorong , Lu Zhongwei , Long Xingxing , Luo Cong , Zuo Juan , Cao Yixiong , Wen Feng , Li Junjun , Luo Zeyu
Published: April 2024

Introduction

Long non-coding RNA (lncRNA) nuclear enriched abundant transcript 1 (NEAT1) is confirmed to be involved in regulation of the multiple myeloma (MM) process. However, its underlying molecular mechanism deserves further investigation.

Material and methods

Quantitative real-time PCR was used to examine NEAT1, microRNA (miR)-133a and actin-related protein 2/3 complex subunit 5 (ARPC5) expression. Cell proliferation and apoptosis were evaluated by cell counting kit 8 assay, soft-agar colony formation assay and flow cytometry. Dual-luciferase reporter assay was used to confirm the interaction between miR-133a and NEAT1 or ARPC5. The localization of NEAT1 and miR-133a in MM cells was determined by fluorescent in situ hybridization assay. In addition, animal experiments were conducted to explore the effect of NEAT1 knockdown on MM tumor growth in vivo.

Results

NEAT1 had increased expression in MM patients and cells. NEAT1 knockdown could repress MM cell proliferation and enhance apoptosis. NEAT1 could sponge miR-133a, and miR-133a could target ARPC5. MiR-133a was lowly expressed and ARPC5 was highly expressed in MM patients. MiR-133a inhibitor could abolish the suppressive effect of NEAT1 knockdown on MM cell growth, and these effects also could be reversed by ARPC5 silencing.

Conclusions

Animal experiments showed that NEAT1 downregulation reduced MM tumor growth by regulating miR-133a/ARPC5 axis. NEAT1 facilitated MM progression through the regulation of miR-133a/ARPC5, which provided new evidence that NEAT1 was a potential therapeutic target for MM.
Role of nutrition and healthy lifestyle, for individuals in primary prevention: recent data, gaps in evidence and future directions
Authors: Metsovitis Theodora , Bernardi Marco , Bruckert Eric , Fogacci Federica , Cicero Arrigo , Garcia-Zamora Sebastian , Spadafora Luigi , Angoulvant Denis , Biondi-Zoccai Giuseppe , Sabouret Pierre
Published: April 2024

All recent guidelines on cardiovascular prevention have highlighted the role of healthy diet and lifestyle advocating holistic approach to reduce cardiovascular burden among population. Despite these efforts, registries have reported that only a minority of healthcare professionals provide advice on diet and lifestyle, and, in most cases, counseling is suboptimal for several reasons. Cardiovascular benefits linked to lifestyle and nutrition seem to be underestimated by many patients and doctors.
This overview aims to summarize well-established benefits related to lifestyle and nutrition, discuss the current debates in this field in order to improve awareness among the medical community and to promote a better implementation of non-pharmaceutical measures to prevent the occurrence of atherothrombotic events.
Patterns and prevalence of psychiatric morbidity
among individuals with rheumatoid arthritis
Authors: Khan Ajaz Kariem , Nabi Junaid , Parrey Ashaq Hussain , Rath Prasan Deep , Lone Sanan
Published: April 2024

Objectives

Rheumatoid arthritis (RA) is a chronic autoimmune disorder that affects the joints, causing inflammation, pain, and potential joint damage. Patients with RA are at high risk of developing psychiatric morbidity; it is important to recognize these psychiatric manifestations. The relationship between psychiatric symptoms and RA is complex and can involve various factors, including the impact of chronic pain, inflammation, medications, and the overall burden of managing a chronic illness.
Aim of the study was to systematically investigate and analyze the patterns and prevalence of psychiatric morbidity among individuals diagnosed with RA, with the aim of identifying common mental health conditions, understanding the interplay between RA and psychiatric disorders, and providing valuable insights for improved holistic patient care.

Material and methods

This was a prospective, observational cross-sectional study conducted over a period of three years in patients with RA. Psychiatric morbidity was assessed using International Classification of Diseases-10 criteria and Mini-Plus by dedicated psychiatrists. The diagnosis of RA was confirmed using the 2010 American College of Rheumatology/European Alliance of Associations for Rheumatology (ACR/EULAR) diagnostic criteria for RA and the disease activity was calculated by Disease Activity Score with 28-joint count (DAS28) using the calculator from the RheumaHelper application. The data were analyzed using SPSS, version 23.0.

Results

A total of 1,000 patients with RA were included in this study. Nearly two-thirds of the patients were female (64.8%). The majority of patients belonged to the age group of 41 to 54 years. Total 47.5% of the patients were unemployed, 27.0% were salaried, 19.0% were businessman, while 6.5% of the patients were students. More than half of the patients (53.2%) had moderate disease activity. Major depressive disorder was the most commonly observed comorbidity (41.0%), followed by somatoform disorder (28.5%), and generalized anxiety disorder was found in 13.5%. No psychiatric manifestations were found in 17% of studied individuals.

Conclusions

Psychiatric morbidity is associated with RA and there is a need for psychiatric services to be made available to these patients.
Bilateral rapidly destructive coxopathy in rheumatoid arthritis
Authors: Dimitrov Stoimen , Gerganov Georgi , Bogdanova Simona , Hristova Svetlana , Moraliyska Rosina , Dimitrov Svetoslav , Apostolova Zhaklin , Simeonova Desislava , Shivacheva Tanya , Georgiev Tsvetoslav
Published: April 2024

Rapidly destructive coxopathy (RDC) is a rare type of coxarthritis marked by swift deterioration of the hip joint. Although its cause remains unclear, several pathophysiological mechanisms are proposed. To comprehensively analyze this poorly understood condition, a literature search was conducted focusing on associations of bilateral RDC and rheumatoid arthritis (RA).
The problem of long-standing RA, bilateral RDC with a febrile episode that preceded a rapid decline in mobility and severe hip pain, with radiological assessment confirmed bilateral hip destruction, was presented.
Rapidly destructive coxopathy, especially when linked to RA, poses diagnostic and therapeutic challenges. Our review confirmed by the clinical picture emphasizes the need for vigilance in RA patients with hip involvement and calls for further research to understand RDC’s mechanisms and enhance clinical care.
ATTITUDES OF TEACHERS TOWARDS LEARNERS WHO ARE MENTALLY CHALLENGED IN NYAMAIYA DIVISION NYAMIRA COUNTY, KENYA; A CROSS SECTIONAL STUDY.
Authors: Nyareso Isoe Joyce , Chelilim David
Published: April 2024

Background:
This study aims to find out the attitudes of teachers toward learners who are mentally challenged in Nyamaiya division of Nyamira County, Kenya.
 Methodology:
This study adopted a cross-sectional survey research design. The study was conducted in Nyamira Township, Nyamira County Kenya. The target population needed all countries in the continent as they served less than 1% of the population with special needs consisting of head teachers and teachers of public primary schools. The total number of teachers was 260. The study adopted proportionate random sampling to select (30%) of public primary schools from the township. The data was generated using questionnaires and observation schedules.
 Results:
The gender distribution of the respondents shows that 48 (61.5%) are males, while 30 (38.5%) are females. data reveals that teachers in Nyamaiya Division generally have mixed attitudes towards learners who are mentally challenged. Only 12.8% strongly agree, 19.2% agree, 2.6% are neutral, 51.3% disagree, and 14.1% strongly disagree. The majority of teachers either have negative attitudes or are unsure about their stance. There was a pessimistic view among teachers regarding the academic potential of mentally challenged learners. Only 7.7% strongly agree, 7.7% agree, while a significant 33.3% strongly disagree.
 Conclusion:
The identified gaps in attitudes underscore the urgency of a multifaceted approach involving targeted interventions, resource allocation, and collaborative efforts among stakeholders. The study emphasizes the need for strategic investments in training, infrastructure, and awareness programs to create an inclusive educational environment conducive to the holistic development of all learners.
 Recommendation:
Awareness Campaigns: Launch awareness campaigns targeting both teachers and regular students to foster a positive and inclusive mindset, reducing negative attitudes towards mentally challenged learners.
What Makes Bureaucracies Politically Resilient? Evidence from Brazil’s Covid‐19 Vaccination Campaign
Authors: Rich Jessica A.J. , Fonseca Elize Massard da , Bower Liam
Published: April 2024

This article sheds new light on the drivers of bureaucratic resilience in the face of presidential attacks, an understudied but politically salient topic. Scholars have long shown how political advocacy can protect bureaucracies from presidential attacks on policy regulation. We argue,
however, that advocacy is insufficient to defend bureaucracies against attacks on policy implementation, which occurs largely outside the formal political arena. Through a case study of Brazil’s successful Covid‐19 vaccination campaign, we call attention to two additional forms
of support for agencies under attack–resource provision and social activism–that come into play during the implementation phase of policy. In conjunction with political advocacy, resource provision and social activism bolster bureaucracies under attack by filling in where other
forms of support fall short.
Impactos do programa Reuni na UTFPR – Campus Ponta Grossa:
Authors: Zander Tatiane Marisa Marafigo , Alberto Pilatti Luiz
Published: April 2024

O presente trabalho tem como objetivo compreender, os impactos do Programa de Apoio a Planos de Reestruturação e Expansão das Universidades Federais (Reuni) no Campus Ponta Grossa da Universidade Tecnológica Federal do Paraná (UTFPR). O corpus de pesquisa foi composto por documentos do Reuni, da UTFPR e entrevistas semiestruturadas. O procedimento utilizado nas entrevistas foi a análise de conteúdo. Constatou-se que o Campus Ponta Grossa cumpriu a maioria dos compromissos assumidos na pactuação do Reuni, principalmente a expansão de vagas na graduação, a abertura de novos cursos na graduação e pós-graduação, a atualização e expansão da estrutura física do campus e a aquisição de novos equipamentos. O número de servidores destinados para o campus também foi maior que o inicialmente previsto. Os compromissos não cumpridos foram relacionados com a evasão estudantil e retenção de alunos. Conclui-se que os impactos da participação do Campus Ponta Grossa foram muito mais positivos que negativos.
Com a palavra os estudantes:
Authors: Pinheiro Barbosa Junior Walter , De Vasconcelos Cavalcanti Adriana
Published: April 2024

Este artigo discute a micropolítica escolar, com foco na participação dos estudantes do 9º ano na gestão educacional de uma escola cooperativa. É o resultado de uma pesquisa de mestrado, para compreender como os estudantes participam da gestão de uma escola, cuja razão de ser institucional é fazer os estudantes pensar melhor. O estudo seguiu pelo viés da pesquisa qualitativa e o arcabouço teórico sustenta-se no pensamento e fundamentação teórica de Célestin Freinet e de Paulo Freire. Concluímos que a escola estudada faz sua gestão escutando os seus alunos e atentamente, implementa sua política e pedagogia, incluindo, nas decisões da escola, as opiniões e recomendações dos estudantes, sendo lugar transformador e escola para vida.
Langerhans Cell Histiocytosis in the Sphenoid Wing
Authors: Tee Shao Peng , Md Shukri Norasnieda , Kanagaratnam Kuhan , Bin Mohamad Mahbob Hafiz , Alias Azah Syahrina
Published: April 2024

Langerhans Cell Histiocytosis (LCH) is a rare and broad-spectrum of disease caused by uncontrolled proliferation of pathologic Langerhans cell resulting in localize and systemic organ infiltration. The clinical presentation can be unspecific and varies between individuals depending on the anatomical location and organ involvement. In view of bony infiltration is the most common in LCH, clinicians have to deal with the challenge of diagnosis dilemmas such as Giant Cell Tumour, Ewing’s sarcoma, osteogenic sarcoma, plasmacytoma, osteomyelitis or bony metastasis, particularly from neuroblastoma. Hence, it requires an excellent multidisciplinary team to establish the diagnosis and start targeted treatment early to prevent fatal complications. The treatment modalities include surgery, immunosuppressive therapy, chemotherapy or in combination. Recently, a seven months old boy presented to our centre with one-week duration of left cheek swelling and left eye proptosis. After detailed clinical evaluation together with imaging and biopsy, the lesion over the bilateral sphenoid and left zygoma were concluded to be Langerhans Cell Histiocytosis (LCH).
Uso eficiente del agua en las empresas agrícolas familiares en el Noroeste de México
Authors: Vega-López Laura Leticia , Sagarnaga-Villegas Leticia Myriam , Zepeda-Zepeda José Adolfo , Salas-González José María
Published: April 2024

Actualmente existe agotamiento de recursos  naturales  debido  a  los excesivos hábitos de consumo y patrones de producción en el mundo entero; por tal motivo, es necesaria la concientización del uso eficiente del agua en los diferentes ámbitos. En México, el 76 % del agua se utiliza en la agricultura; 14 % en el abastecimiento público; 5 % en las termoeléctricas y 5 % en la industria. La presente investigación se enfocó en “Empresas Familiares Agrícolas”, ubicadas en Santiago Ixcuintla, Nayarit, México; donde 64 % de la superficie utiliza el riego en cultivos como: frijol, tabaco, caña y hortalizas; el objetivo es identificar los factores que influyen para que estas empresas utilicen eficientemente el agua, así como, la problemática y las expectativas de los empresarios en cuanto a las áreas de desarrollo y mejora de su empresa.
En los resultados se obtuvieron 25 mil observaciones derivadas de 91 encuestas a empresarios agrícolas, se observó que en las actividades productivas las empresas no utilizan eficientemente el agua, ya que se considera que este recurso es abundante. Asimismo, los empresarios están considerando regresar al riego por gravedad, dado que las nuevas tecnologías de riego generan mayores costos de producción; sin embargo, la edad, el nivel de escolaridad y la generación a la que pertenecen los integrantes de las empresas, influyen positivamente en el uso eficiente del agua, pues una mayor educación permite a los productores tener mayor conciencia sobre los problemas medioambientales en general. Las ayudas públicas facilitan la incorporación de nuevas tecnologías y las expectativas que tienen los productores sobre su empresa en los próximos años es positiva.
POLOŽAJ BOŠNJAKA U SRJ I REPUBLICI SRBIJI OD
1992. GODINE DO 2000. GODINE
Authors: Škrijelj Ahmedin
Published: April 2024

Basing our work on facts we will describe and present the position of Bosniaks in San-
džak in the period from 1992 to 2000. We will analyze the constitutional and legal po-
sition, political organization and activities of Sandžak Bosniaks in that period, as well
as the repression and violation of human rights, that is, the organized state terror
that was perpetrated against Bosniaks, as well as the attitude of the Serbian state
authorities towards this issue after the overthrow of Slobodan Milošević ‘s regime.
Key words: Bosniaks, Sandžak, Federal Republic of Yugoslavia, Republic of Serbia,
constitutional and legal position, repression, organized state terror, torture, violation
of human rights, judicial and political processes, discrimination
USKLAĐIVANJE ZAKONODAVNOG OKVIRA BOSNE I
HERCEGOVINE S PRAVNOM STEČEVINOM EUROPSKE
UNIJE I SLOBODA POSLOVNOG NASTANA
Authors: Gongeta Sanja , Gongeta Vedran
Published: April 2024

Freedom of establishment is one of the fundamental freedoms guaranteed by the
Treaty on the Functioning of the European Union. It ensures the free movement of
business entities and experts within the single market of the European Union. The
recent changes to the European legislative framework, which ensure the implemen-
tation of this fundamental freedom in the European Union, adequately responded
to the challenges posed to the European legislator by the digital revolution and the
Covid pandemic. The aim of the paper is to determine how much the legislator in Bo-
snia and Herzegovina follows European trends in the modernization of the legal fra-
mework of commercial (business) companies, with special emphasis on the elements
of freedom of business establishment.
Key words: freedom of business establishment; legal acquis; European Un-
ion; Bosnia and Herzegovina
PREVENCIJA I MIRNO RJEŠAVANJE RADNIH
SPOROVA U FEDERACIJI BOSNE I HERCEGOVINE
Authors: Selesković Admir
Published: April 2024

Procedures and mechanisms for effective prevention and peaceful resolution of la-
bor disputes are of key importance for promoting healthy labor relations, ensuring a
functional labor management system and improving access to justice, for employers
as well as for workers. On the other hand, the peaceful resolution of labor disputes
has multiple significance for the state as well, as it leads to the relief of the courts
from lengthy procedures, but also to an increase in the efficiency of the work of the
judiciary in a wider context. Peaceful resolution implies “out-of-court” alternative
options for resolving labor disputes, i.e. conciliation, mediation and arbitration. A
significant progress in the reform and modernization of labor legislation in the Fede-
ration of Bosnia and Herzegovina is the adoption of the Law on Peaceful Resolution of
Labor Disputes from 2021. This paper aims to present an analysis of the aforementi-
oned Law, but at the same time points out the importance of applying indispensable
instruments and standards in the process of prevention and peaceful resolution of
labor disputes, established in the conventions and recommendations of the Interna-
tional Labour Organization. In sense of the increasing digitization of many aspects
of social life, which has also affected the field of law, the paper will briefly analyze
relatively recent phenomenon of online dispute resolution. Ultimately, the paper will
offer de lege ferenda proposals in order to further improve the institute of peaceful
resolution of labor disputes in the Federation of Bosnia and Herzegovina.
Key words: labor dispute, prevention, peaceful resolution, conciliation, arbitration