bluuebunny/crossref_metadata_2025 huggingface dataset:
Hypoimmune induced pluripotent stem cell–derived cell therapeutics treat cardiovascular and pulmonary diseases in immunocompetent allogeneic mice
Authors: Deuse Tobias , Tediashvili Grigol , Hu Xiaomeng , Gravina Alessia , Tamenang Annika , Wang Dong , Connolly Andrew , Mueller Christian , Mallavia Beñat , Looney Mark R. , Alawi Malik , Lanier Lewis L. , Schrepfer Sonja
Published: July 2021

Significance

Precise gene editing allows engineering of immune receptors and ligands to reduce the immunogenicity of cells, and strategies for the generation of immune-evasive stem cell sources are currently being developed. This article describes the translational aspect of generating universally transplantable, disease-specific, therapeutic cell products. We provide proof of concept that immune-engineered cells can treat major cardiovascular and pulmonary diseases in fully allogeneic subjects without utilizing any immunosuppression. The translational aspect is emphasized by showing improvements in clinically relevant outcome measures, which are widely used in human trials. Depending on the feasibility of large-scale manufacturing of universal cell therapeutics, this approach could enable cost-effective cell therapy.
The GAS6-AXL signaling pathway triggers actin remodeling that drives membrane ruffling, macropinocytosis, and cancer-cell invasion
Authors: Zdżalik-Bielecka Daria , Poświata Agata , Kozik Kamila , Jastrzębski Kamil , Schink Kay Oliver , Brewińska-Olchowik Marta , Piwocka Katarzyna , Stenmark Harald , Miączyńska Marta
Published: July 2021

Significance

Metastasis remains the major cause of cancer-related deaths. Overactivation of receptor tyrosine kinase AXL has been correlated with cancer invasion and metastasis, resistance to therapies, and poor patient prognosis. However, the cellular processes activated by AXL and its ligand, GAS6, are largely unknown. Here, we identified a proximity interactome of AXL and revealed actin-dependent processes activated by GAS6-AXL, including membrane ruffling and macropinocytosis, that provide insights into the role of AXL in cancer progression. The identified AXL interactors can be used in translational research toward development of effective therapies for metastatic and/or chemoresistant cancers with AXL overactivation. Moreover, our data provide a mechanistic explanation for previous studies reporting that AXL might contribute to macropinocytic uptake of viruses.
Live imaging of remyelination in the adult mouse corpus callosum
Authors: Bottes Sara , Jessberger Sebastian
Published: July 2021

Significance

Oligodendrocyte precursor cells (OPCs) retain the capacity to remyelinate axons upon demyelinating injury. However, mode of cell division and differentiation dynamics of individual OPCs in deep brain structures, such as the corpus callosum, remains unknown. Using in vivo two-photon imaging in a focal model of demyelination, we show that OPCs undergo several rounds of symmetric and asymmetric cell divisions before producing a subset of daughter cells that differentiates into myelinating oligodendrocytes. The data presented here characterize the behavior of OPC clones and delineate the cellular principles that lead to remyelination.
Landscape of innate lymphoid cells in human head and neck cancer reveals divergent NK cell states in the tumor microenvironment
Authors: Moreno-Nieves Uriel Y. , Tay Joshua K. , Saumyaa Saumyaa , Horowitz Nina B. , Shin June Ho , Mohammad Imran A. , Luca Bogdan , Mundy David C. , Gulati Gunsagar S. , Bedi Nikita , Chang Serena , Chen Chen , Kaplan Michael J. , Rosenthal Eben L. , Holsinger F. Christopher , Divi Vasu , Baik Fred M. , Sirjani Davud B. , Gentles Andrew J. , Newman Aaron M. , Freud Aharon G. , Sunwoo John B.
Published: July 2021

Significance

NK cells have been observed to be present within most solid tumors, but the antitumor activity of the intratumoral NK cells has been unclear. In this study, we examined the entire spectrum of innate lymphoid cells within primary human tumors and demonstrate that peripheral NK cells in the tumor microenvironment differentiate into heterogeneous cell states, resulting in either a hyporesponsive NK cell subset or a highly active NK cell phenotype that closely resembles intraepithelial ILC1s and that has potent antitumor properties. Importantly, this differentiation into ieILC1-like cells occurs when NK cells are cocultured with epithelial cells, providing important information for NK cell immunotherapy approaches.
Ciliopathy genes are required for apical secretion of Cochlin, an otolith crystallization factor
Authors: Leventea Eleni , Zhu Zhou , Fang Xiaoming , Nikolaeva Yulia , Markham Eleanor , Hirst Robert A. , van Eeden Fredericus J. M. , Malicki Jarema J.
Published: July 2021

Significance

We found that genes associated with human ciliopathies modulate apicobasal polarity of secretion. In addition, we showed that this is essential for the function of Cochlin, the protein associated with DFNA9, a human nonsyndromic deafness with vestibular dysfunction. Cochlin is secreted by a group of specialized epithelial cells both apically and basally in the ear. We found that apically secreted Cochlin is essential for proper otolith formation. In this way, we offer a plausible molecular explanation as to why DFNA9 patients suffer from balance disorders. The involvement of cilia genes in polarized secretion is an additional function for this otherwise very well-studied and medically important group of genes.
Identification of simple arylfluorosulfates as potent agents against resistant bacteria
Authors: Zhang Jiong , Zhao Xiangxiang , Cappiello John R. , Yang Yi , Cheng Yunfei , Liu Guang , Fang Wenjing , Luo Yinzhu , Zhang Yu , Dong Jiajia , Zhang Lixin , Sharpless K. Barry
Published: July 2021

Significance

Excessive use of antibiotics for patient therapy and livestock results in the selection of pathogenic bacteria resistant to multiple drugs. The spread of multidrug-resistant bacteria into the community is associated with increased morbidity, mortality, and financial burden of health care. We constructed a library of SuFEx-derived arylfluorosulfates that demonstrated potent activities in combating multidrug-resistant bacteria both in vitro and in vivo. Significantly, these arylfluorosulfate analogs show enhanced potency to disrupt bacterial biofilm as well as kill persisters and have a synergistic effect with clinical bactericidal drugs. This study suggests that arylfluorosulfates derived from SuFEx-based modification of phenols could serve as a convenient strategy to search for bactericidal candidates.
Separation of presynaptic Ca
v
2 and Ca
v
1 channel function in synaptic vesicle exo- and endocytosis by the membrane anchored Ca
2+
pump PMCA
Authors: Krick Niklas , Ryglewski Stefanie , Pichler Aylin , Bikbaev Arthur , Götz Torsten , Kobler Oliver , Heine Martin , Thomas Ulrich , Duch Carsten
Published: July 2021

Significance

Synaptic vesicle (SV) release from presynaptic terminals requires nanometer precise control of action potential (AP)–triggered calcium influx through voltage-gated calcium channels (VGCCs). SV recycling also depends on calcium signals, though in different spatiotemporal domains. Mechanisms for separate control of SV release and recycling by AP-triggered calcium influx remain elusive. Here, we demonstrate largely independent regulation of release and recycling by two different populations of VGCCs (Ca
v
2, Ca
v
1), identify Ca
v
1 as one of potentially multiple calcium entry routes for endocytosis regulation, and show functional separation of simultaneous calcium signals in the nanometer space of a presynaptic terminal by the plasma membrane calcium ATPase (PMCA). The Ca
v
2/Ca
v
1/PMCA functional triad may provide conserved means for independent control of different vital presynaptic functions.
1,2-Difunctionalized bicyclo[1.1.1]pentanes: Long–sought-after mimetics for
ortho
/
meta
-substituted arenes
Authors: Zhao Jin-Xin , Chang Yu-Xuan , He Chi , Burke Benjamin J. , Collins Michael R. , Del Bel Matthew , Elleraas Jeff , Gallego Gary M. , Montgomery T. Patrick , Mousseau James J. , Nair Sajiv K. , Perry Matthew A. , Spangler Jillian E. , Vantourout Julien C. , Baran Phil S.
Published: July 2021

Significance

Bioisoteric replacements for aromatic rings to improve medicinal properties are in high demand. This work presents a comprehensive analysis of heretofore-inaccessible 1,2-difunctionalized bicyclo[1.1.1]pentanes from both chemical and biological vantage points. This analysis will aid those in drug discovery regarding when the application of such systems makes sense and how to access them in such circumstances.
Fundamental and higher-order excited modes of radial oscillation of neutron stars for various types of cold nucleonic and hyperonic matter
Authors: Barta Dániel
Published: July 2021

This research paper complements our earlier qualitative study of the effect of viscosity and thermal conductivity on the radial oscillation and relaxation of non-rotating neutron stars. The fundamental and first two lowest-frequency excited modes of radial oscillation have been computed in the high nuclear density regime for a set of seven realistic equations of state (EoS) as functions of central energy density. Various types of zero-temperature EoS of cold nucleonic and hybrid nucleon–hyperon–quark matter models are used in the inner core to determine the internal structure in and around the hydrostatic equilibrium states and investigate the influence of each EoS on the dynamical behavior of non-rotating neutron stars. We confirm the principal results of earlier, related studies that suggest an underlying correlation between the frequency spectrum of the fundamental oscillation mode and the variation of the adiabatic index over the high nuclear-density regime. We provide valuable information to impose further constraints on the plausible set of realistic EoS models, in addition to the practical applications for the rapidly evolving field of asteroseismology of compact objects.
Light emission from halide perovskite semiconductors: bulk crystals, thin films, and nanocrystals
Authors: Yamada Takumi , Handa Taketo , Yamada Yasuhiro , Kanemitsu Yoshihiko
Published: July 2021

Halide perovskites are attracting attentions as a novel class of semiconductor materials for devices such as solar cells, light-emitting diodes, lasers, and photodetectors. High-quality perovskite crystals can be fabricated with different forms such as bulk crystals, thin films and nanocrystals. These different geometries influence photoluminescence (PL) properties, and the characteristic differences of PL spectra between bulk single crystals and polycrystalline thin films are originated from the carrier diffusion and PL reabsorption. Nanocrystals exhibit optical properties different from their bulk counterparts due to size effects. Furthermore, the bandgap energies of perovskites can be tuned over a wide range by controlling the constituents. Unique anti-Stokes PL and high-order harmonic generation have also been demonstrated in nanocrystals in addition to bulk crystals and thin films. In this review article, we provide a brief summary of the PL and nonliear light emission properties of perovskite semiconductors. We first discuss the influence of the carrier diffusion and PL reabsorption on the PL spectra and dynamics of thick samples, and then the impact of the electron–phonon interactions on PL spectra in bulk crystals and nanocrystals. The last part of this review is devoted to the light emission phenomena induced by nonlinear optical processes in perovskites.
Invariant-based inverse engineering for fast nonadiabatic geometric quantum computation
Authors: Li Wei
Published: July 2021

In this paper, based on first given Lewis–Riesenfeld invariant depicted by a unit vector in parameter space, we inverse engineering the time-dependent Hamiltonian of a system with su(2) Lie algebraic structure. The introduced method is then applied to investigate nonadiabatic Abelian geometric quantum computation. We demonstrate that, by employing the nonadiabatic Berry phase generated through nonadiabatic periodic evolution, a driven two-level system which undergoes a single cyclic evolution along a loop path in Bloch space can realize a universal set of one-qubit gates. Subsequently, under consideration of the influence of the systematic error and dissipation on nonadiabatic process, the result reveals arbitrary one-qubit gate can be implemented with a high fidelity. Moreover, to complete the universal set, arbitrary controlled-U gate is designed by utilizing a driven system consisted of a pair of coupled spin subsystems.
Corrigendum: Tensor Computations of Stochastic Dynamic Fields (2021 Journal of Physics: Conference Series (JPCS). Vol. 1828, 012038)
Authors: Zhang Yinsheng
Published: July 2021

Please see Article PDF for corrigendum text.
Spatial configuration and time of day impact the magnitude of urban tree canopy cooling
Authors: Alonzo Michael , Baker Matthew E , Gao Yuemeng , Shandas Vivek
Published: July 2021

Tree cover is generally associated with cooler air temperatures in urban environments but the roles of canopy configuration, spatial context, and time of day are not well understood. The ability to examine spatiotemporal relationships between trees and urban climate has been hindered by lack of appropriate air temperature data and, perhaps, by overreliance on a single ‘tree canopy’ class, obscuring the mechanisms by which canopy cools. Here, we use >70 000 air temperature measurements collected by car throughout Washington, DC, USA in predawn (pd), afternoon (aft), and evening (eve) campaigns on a hot summer day. We subdivided tree canopy into ‘soft’ (over unpaved surfaces) and ‘hard’ (over paved surfaces) canopy classes and further partitioned soft canopy into distributed (narrow edges) and clumped patches (edges with interior cores). At each level of subdivision, we predicted air temperature anomalies using generalized additive models for each time of day. We found that the all-inclusive ‘tree canopy’ class cooled linearly at every time (pd = 0.5 °C ± 0.3 °C, aft = 1.8 °C ± 0.6 °C, eve = 1.7 °C ± 0.4 °C), but could be explained in the afternoon by aggregate effects of predominant hard and soft canopy cooling at low and high canopy cover, respectively. Soft canopy cooled nonlinearly in the afternoon with minimal effect until ∼40% cover but strongly (and linearly) across all cover fractions in the evening (pd = 0.7 °C ± 1.1 °C, aft = 2.0 °C ± 0.7 °C, eve = 2.9 °C ± 0.6 °C). Patches cooled at all times of day despite uneven allocation throughout the city, whereas more distributed canopy cooled in predawn and evening due to increased shading. This later finding is important for urban heat island mitigation planning since it is easier to find planting spaces for distributed trees rather than forest patches.
Finite Element Calculation of Whole Ship Structure Strength of 1500DWT Modified Bulk Cement Barge
Authors: Ren Jinyu , Xu Jing
Published: July 2021

According to the structure of the original 1700DWT barge and the requirements of “Code for Construction of Steel Inland Ships (2012)”, the dimensions of each component will be redesigned. Then use MSC.Patran to establish the whole ship finite element model, assign element properties according to the newly designed dimensions, and apply the load according to the principle of unfavorable load combination under different working conditions. Use MSC. Nastran to perform yield strength analysis. The calculations were carried out to carry out load analysis and calculation under typical working conditions to obtain the detailed stress distribution and deformation of the whole ship. The results show that it is feasible and reliable to use the method of direct calculation of the structural strength of the whole ship.
Study on Calculation and Analysis of Foundation Settlement in Cooling Tower
Authors: Zhang Jianyou , Du Rong
Published: July 2021

Based on the foundation characteristics of the 1200 m2 hyperbolic natural draft cooling tower in a power plant, and after analyzing many kinds of standards, the method is decided which could be used for foundation Settlement Calculation of the foundation in the cooling tower; The results of calculation are analyzed, when using natural foundation, the foundation Settlement deformation of the cooling tower can satisfy the design requirements.
Experimental research on the laws of acidification and salinization under the conditions of Ionic rare earth leaching and water Leaching
Authors: Chen Bin , Chen Guoqiang , Huo Hanxin , Zhu Yibin , Zhai Wenlong
Published: July 2021

In the ionic rare earth mining,ammonium sulfate is used as a leaching agent for in-situ leaching, the concentration of ammonium sulfate is 2%∼3%, and the pH is 4∼5, leading to soil acidification and increased salt content. In this paper,taking a rare earth mining area in Guangdong as the research object, carried out soil column simulation test research. After leaching with water for the soil column that complete leaching, in condition of using different leaching agents of pH values and different water leaching process characteristics, the variation of pH and total salt content was studied. The results show that, after leaching ,the mineral sample changed from mild acidification to non-acidification, and the the salt content of the mineral sample was effectively reduced, the salt leaching rate is above 57%. The research conclusions laid a theoretical foundation for soil acidification and salinization control in ion-type rare earth mining areas.
Integrated Petrophysical Evaluation of Shale Gas Reservoirs for Wufeng-Longmaxi Formation in Southeast Chongqing
Authors: Yan Ping , Kou Xiaopan , Hu Gang , Yin Qian , Zhang Lina , Wang Wei , Lai Fuqiang
Published: July 2021

Shale gas is an important unconventional natural gas resource. Different from conventional oil and gas exploration, gas shale is not only the source rock of natural gas, but also the cap rock and reservoir. This paper presents a logging interpretation method for comprehensive evaluation of shale gas. Taking well A in southeast Chongqing from Sichuan Basin as an example, the shale gas reservoir of Wufeng-Longmaxi formation is evaluated. This method makes full use of conventional logging data (gamma ray, array lateral resistivity, density, neutron, acoustic, spectral gamma ray), unconventional log data (NMR Nuclear Magnetic Resonance, ECS Elemental Capture Spectroscopy) and core experiment data (X-ray Diffraction, Tight Rock Analysis, Methane Adsorption Isotherm). This method of combining logging data with core measurement can provide mineralogy, porosity, permeability, saturation, kerogen volume, total organic carbon content, absorbed gas content and free gas content. The methods provide a means to understand the petrophysical properties and reservoir quality of Wufeng-Longmaxi shale. This information can help to determine the “sweet spot” along the vertical to land and design a selective completion strategy to optimize well productivity.
Sensitivity Analysis of the Parameters Affecting Bottom-hole Pressure during Foam Underbalanced Drilling
Authors: Zhang Xiaoning , Li Lingdong , Zhang Jianli , Duan Luyi , Wang Guangtai
Published: July 2021

With many advantages of protecting reservoir, increasing drilling speed and high capacity in carrying cuttings, foam drilling is suitable for drilling through the aquifer and natural fractured formation, and has been developed fast since 1990s. However, the change of the foam physical properties along wellbore, and the flowing state of the foam in the annulus is complex. Therefore, it is difficult to optimize the design of hydraulic parameters for foam drilling. In order to solve this problem, the mathematical model for foam-cutting flowing in annulus has been developed. In addition, the sensitivity analysis has been conducted about the factors affecting the parameters of foam drilling and the characteristics of foam flowing. The analyzing results can provide the foundation for designing the hydraulic parameters of foam drilling.
Coal Consumption Determination Method and Its Application Based on Actual Running State for Unit
Authors: Wang Jiayong , Deng Debing , Zhao Qingsen , Zhang Ding , Yang Jie , Chen Wei , Dai Junke , He Bulang
Published: July 2021

In the daily energy-saving statistics of coal-fired power stations, the imbalance of the total standard coal consumption often occurs. The fundamental reason is that the boundary conditions of the steam turbine side heat rate calculation and the boiler efficiency calculation are not unified. The article first analyzes the existing calculation methods, and points out that the anti-equilibrium calculation of boiler thermal efficiency lies in various loss calculations, and the key to the calculation of steam turbine heat consumption rate lies in the calculation of heat absorption. The heat consumption rate of the steam turbine is based on the flow into the turbine. The loss of working fluid on the turbine side, such as oxygen exhaust, high-pressure operation exhaust, sampling, valve leakage, etc., have been taken into account. Sampling, heat tracing in the ammonia station, and leakage from the boiler side run-off do not affect the boiler efficiency, nor the calculation of the turbine heat consumption rate, but affect the overall operation level of the unit. This article researchs the calculation method of coal consumption for power supply,taking a 600MW condensing power plant as an example, the main reasons for the difference in calculation results are analyzed, which lays the foundation for energy-saving diagnosis and energy-saving potential of the whole plant.
Effect of volcanic activities on the characteristic of sedimentary and sedimentary facies model-- Taking the Jiangbasitao Formation in Wulungu area as example
Authors: Ni Shengli , Yu Hongzhou , Sun Hongzhen , Wang Qianjun , Xiong Zhengrong , Bai Zhongcai
Published: July 2021

At present, the northern margin of Junggar Basin is one of the key zone in oil-gas exploration fields. For the purpose of explaining the question about the effect of volcanic activities on the characteristic of sedimentary, with the Wulungu area in the northern margin of Junggar Basin, the sedimentary characteristics was studied comprehensively using methods of core, drilling and a large number of sedimentologic experiment. The results have confirmed that the types of sedimentary facies, mainly marine. Combining with the construction environment, the sedimentary facies model (inter-arc basin and back-arc basin) were established for this area.
Sedimentary characteristics and evolution model of the late Permian in the periphery of the Bogda Mountain
Authors: Wang Yue , Zhang Kuihua , Xiong Wei , Yu Hongzhou , Zhang Guanlong , Wang Yuxin , Xue Yan
Published: July 2021

The Upper Permian around Bogda Mountain develops favorable reservoir sand bodies which show good oil and gas display. Further study of the sedimentary characteristics and evolution models has guiding significance towards petroleum exploration. Through detailed obervation and measurement of the Permian in the typical profile of the periphery of Bogda Mountain, combined with the well drilling and logging data and the core data of the Chaiwobao depression, the strata characteristics, the sedimentary facies types and the distribution features of the studying area were carefully analysized, furtherly, the sedimentary evolution model of the Upper Permian was discussed. It was revealed that the Quanzijie Formation, the Wutonggou formation and the Guodikeng Formation were formed from the bottom up in the late Permian in the periphery of Bogda Mountain, which was a transgression sedimentary process. During the sedimentary period of Quanzijie Formation, the uplift amplitude of Bogda Mountain was relatively large. Alluvial fan and fan delta facies are mainly developed on the north and south sides of Bogda Mountain. During the sedimentary period of Wutonggou Formation, with the uplift amplitude of bogda mountain gradually decreased, the northern margin of bogda mountain was mainly deposited by braided river and meandering river, while the southern margin was still mainly deposited by alluvial fan. During the sedimentary period of Guodingkeng Formation, with the gradual shrinkage of Bogda Mountain, the northern margin of Bogda Mountain mainly developed the flood plain deposits of the meandering river, which reflected that the material supply capacity was weakened.
Main controlling factors and depositional model of source rock of Paleogene Shahejie Formation in Liaodong Bay Depression
Authors: Hou Qingjie , Jin Qiang , Zhang Rucai , Liu Haojie , Wang Yuping , Sheng Wenbo
Published: July 2021

In the Paleogene Shahejie Formation of Liaodong Bay Depression, two sets of main source rocks are developed, namely the Es1 and the Es3 Formation. In order to determine the characteristics, main controlling factors and patterns of source rock development, firstly, we comprehensively use source rock geochemical and logging data to establish TOC logging prediction models for source rocks in two formations; secondly, we predict the TOC plane distribution of the two layers separately according to the prediction model; then, we use the tectonic subsidence history and sedimentary background data of the study area to analyze its relationship with the source rock development and determine the main controlling factors for the source rock development; finally, the source rock deposition models are established according to the main controlling factors of source rock development. The results show the source rock of the Es1 has high abundance of organic matter, the average TOC of the sample is as high as 2.41%, but the thickness of the source rock does not exceed 130 m; the abundance of source rocks in the Es3 is slightly worse than that of the Es1, the average TOC of the samples is 1.75%, the thickness of source rocks is generally larger, mainly 200-350 m; the rate of tectonic subsidence controls the thickness of the source rock, the amount of fracture extension controls the distribution shape of the source rock, and the degree of water stratification controls the degree of source rock enrichment; in the Es1 Formation, the source rock deposition model is the deposition model of the salinity layered water body in the saline lake basin; in the Es3 Formation, the source rock deposition model is the deposition model of deep water temperature stratification in the separated lake basin. To determine the main controlling factors and depositional patterns of source rock development provides a direction for subsequent exploration of favorable areas.
Pore fluids evolution in the sandstone of rift basins: a case study of Dongying sag, Jiyang depression, East China
Authors: Meng Wei , Ren Xianli , Jiang Yue , Li Songxi , Lin Ru
Published: July 2021

Pore fluids in basins control the migration of material and energy in sedimentary basin. Make sure pore fluids evolution process would be important for high-quality reservoir prediction. In this study, we pay attention on Dongying sag, which located in the eastern of Jiyang depression, Bohai Bay basin. We collected core sample for thin section observation and SEM, to determine diagenetic sequence in sandstone of study area. Take geological characteristics of study area into consideration, make sure the source of diagenetic products. At last, we deduce the pore fluids evolution process in study area.
Influence Factors of Pressure Attenuation Gradient and its Reservoir Forming Control - A Case Study of Bonan Sag in Bohai Bay Basin
Authors: Feng Yuelin , Zhang Tianjiao , Wang Yongshi , Mu Xing , Xiong Wei , An Tianxia , Wang Yong
Published: July 2021

As the dynamic condition of oil and gas migration, the change rate of overpressure has a certain relationship with the mode of oil and gas migration. In order to quantitatively identify the mode of oil and gas migration in overpressure basins, the influence of different transmission modes on pressure attenuation gradient is simulated, and the application and discussion are carried out in Bonan sag of Bohai Bay Basin. The influence of different transmission modes on the pressure attenuation gradient is discussed by single factor simulation method. Taking Bonan sag as an example, the process of overpressure fluid migration and accumulation is discussed combined with the evolution process of pressure attenuation gradient. The results show that fault activity has the greatest influence on pressure attenuation gradient, followed by fault dip angle and fault distance. the influence degree of physical properties of skeleton sand body, sand body dip angle and sand body thickness on pressure attenuation gradient decreases in turn; For the fault-sand consistent transport, it mainly depends on the combined effect of the dip angle and resistance of the transport system. The critical value of the fault or sand body transport in Bonan sag is 58.8MPa/km. On this basis, combined with the evolution law of pressure attenuation gradient, it is considered that the overpressure fluid in the deep sag migrates along the oil source fault to the fault terrace zone and the overpressure center distribution of the oil and gas ring in the deep sag. The overpressure oil and gas mainly migrate laterally along the sand body, and the oil and gas are distributed contiguously. In gentle slope zone, oil and gas distribute sporadically at structural height.
Investigation of Drag-Reduction Effect of Super-Hydrophilic Surface in Laminar Microchannel Flow
Authors: Luo Haoyu , Lu Lichang , Hao Yu , Li Xiang , Dong ZhiLi , Liu Yang , Li Yuanzhe
Published: July 2021

In previous studies of newly fabricated surface-coating materials, the super hydrophilic surface etched by Cu2+/HNO3 exerts higher drag-reduction effect at low Reynolds numbers than the modified superhydrophobic surface even with similar surface structure. In this paper, both experimental and modelling fluid dynamics studies are used to invest the drag-reduction and flow field for these super hydrophilic surfaces in the microchannel. The experimental results showed that the drag-reduction rate would gradually decrease with the velocity increment of medium. Besides, the dissolved gas does play a key role in reducing the shear stress in the near wall flow field by forming the non-shear air/water interface and increasing its wall-slippage effect. Moreover, the flow-field stimulation analysis provides more intuitive schematic diagram velocity magnitude and pressure changes inside the microchannel, and the surface roughness obtained by chemical etching is capable to enhance the drag-reduction effect as well.
Hydrocarbon accumulation characteristics and model of deep-seated glutenite on steep slope zone of fault basin: a case study of the E2s4 Member in Yanjia area, Dongying Sag
Authors: Mao Shuwei , Hao Xuefeng , Gong Jianqiang , Zhang Pengfei , Qiu Yibo , Wang Wenbin
Published: July 2021

Deep-seated oil and gas have become the focus of hydrocarbon exploration at home and abroad. Strengthening the research on the deep-seated hydrocarbon accumulation is the key to efficient exploration of oil and gas. Based on the analysis of light component and organic matter types of crude oil, the results show that there are two sets of source rocks in the E2s42 sub-member in Yanjia area, which are self-derived reservoirs. The reservoir types of the deep-seated glutenite in E2s4 member are mainly lithologic and lithologic-tectonic reservoirs. The distribution sequence is characterized by oil reservoirs in the high part of the structure, oil cracking gas reservoirs in the deep part, and condensate oil and gas reservoirs in the middle part. Further analysis shows that there are three layer pressure zones: overpressure zones (PCOE >1.4), the pressure transition zone (1.1 <PCOE<1.4) and the normal pressure zone (0.9 <PCOE<1.1), and the part near the upper fan area is dominated by the crude oil from the E2s42 sub-member, the middle fan area is dominated by the mixed source oil, and the lower fan area is dominated by the crude oil from the E2s41 sub-member. Compared with the characteristics of hydrocarbon migration and accumulation in middle and shallow strata, hydrocarbon accumulation in deep-seated glutenite is more controlled by hydrocarbon migration power and reservoir physical property. The secondary pore development zones are the key reservoir spaces for hydrocarbon in deep layer. On the basis of the above analyses, the hydrocarbon accumulation model of “source-reservoir-pressure” is constructed, which further reveals the hydrocarbon differential enrichment law of deep-seated glutenite, and guides the efficient exploration of oil and gas in Yanjia area, Dongying Sag.
Experimental study on ultra high pressure hydraulic cutting seam pressure relief and permeability enhancement of strip drilling along seam in C19 coal seam of Shiping No.1 Coal Mine
Authors: Lu Zhanjin , Ji Fei
Published: July 2021

In view of the low permeability of C19 coal seam in Shiping No.1 coal mine, the large amount of drilling work and the long time of reaching the standard of extraction, which seriously restricts the replacement of mining, the ultra-high pressure hydraulic cutting technology is adopted to improve the permeability of coal seam. After using ultra-high pressure hydraulic slotting, the average single hole chip removal is 3.31t, the average chip removal per cutter is 0.38t, the width of slotting slot is 4cm, and the equivalent radius of slotting slot is 1.59m. The field test results show that the pressure relief and permeability enhancement effect of 11719 lifting machine roadway (East) in Shiping No.1 mine is significantly improved under this parameter condition. The single hole drainage pure quantity of slotted drilling is 7.8 times that of ordinary drilling, the concentration is increased by 2-2.4 times, the drilling construction quantity is reduced by 30.6%, the drilling drainage time is shortened by 80.7%, and the drilling gas drainage efficiency is greatly improved.
Recognition of sedimentary characteristics in P zone of X oilfield
Authors: Wu Hongjun
Published: July 2021

According to the detailed description of the carrier bed Daqing delta fluvioglacial deposits, channel the sand package of the oil field is intermittently developed and the forecasting function is not sufficient with the expansion of the oil field to find suitable blocks, the principle of high-resolution stratigraphic sequence and the re-examination of the sedimentary system and characteristics of the sediments of the oil field have been introduced. By accurately comparing the strata, a sequence structure of 12 sediment units of the P oil reservoir of a given oil field was established, and sediment microfacies were subdivided. Through a study of the sediment characteristics of the oil reservoir P of the oil field come to be more continuous and extended than previously thought. Moreover, it is essential for the gradual development capacity of irreducible oil.
Study on risk assessment of EPC water conservancy project based on entropy weight set pair analysis
Authors: Meng Jinbo , Zhang Jixiang
Published: July 2021

In recent years, EPC mode has been developed rapidly in water conservancy projects. However, due to the complex construction conditions, long construction period and easy to be affected by natural conditions of water conservancy project, the general contractor of EPC project is faced with greater risks. If the risk analysis is not enough, the project profit of the contractor will be lower than expected or even loss. Water conservancy project risk indicators are qualitative indicators, which are easily affected by subjective factors and quantitative uncertainty in the process of index quantification. In this paper, combined with the relevant research at home and abroad, combined with the characteristics of water conservancy projects, the establishment of water conservancy project risk assessment level index system. The set pair analysis model which can comprehensively evaluate the connection degree between risk index and risk level and the entropy weight model which can reflect the information content of the index are introduced into the risk evaluation of EPC water conservancy project. The evaluation results show that the entropy weight method can calculate the weight of each risk index in the risk level, and the set pair analysis method can comprehensively evaluate the connection degree between the risk index and different risk levels.
Study on creep characteristics and evolution model of slide body in D area of Qinyu landslide
Authors: Xie Wenbin , Bao Xiaojun , Liu Gao , Li Jinqi , Sun Cheng
Published: July 2021

The geological conditions are complex in the Longnan mountain area, and the landslide disasters are widely distributed and numerous, among which the large accumulation layer landslide is especially developed. This kind of landslide is mostly distributed along the river basin and has the characteristics of multi-phase and multistage. The slide body is mostly in the state of creep plastic flow, and it is easy to revive. In this paper, the creep characteristics and evolution model of the secondary landslide were studied based on the field geological survey and the numerical calculation method, in order to provide reference for the monitoring and treatment of the landslide in this area. The results show that the shear stress and shear strain concentration zone is mainly located near the previous sliding surface of the landslide, and the creep type is deep creep; The deformation of the sliding body in zone D show that the deformation of the trailing edge and the middle front is relatively small, while the deformation of the middle and the leading edge is large; At the present stage, the overall deformation mode of the slide body in the D area of Qinyu landslide is a slow creeping deformation mode of traction from the front, down-shifting from the middle to the back.
Research on permeability increasing technology of low permeability combined rock coal seam
Authors: Ma Shuyin
Published: July 2021

Aiming at the problem of improving the permeability of the low permeability combined rock coal seam and the gas drainage effect of a certain mine, the coal seam field engineering test is adopted, and the method of combining the gas drainage effect before and after hydraulic permeability enhancement is used to carry out the underground field test research. The results show that: in the low-permeability combined rock coal seam, the influence radius of 15m of hydraulic fracturing is adopted, which increases the scalar amount of gas drainage by more than 6.44 times and the concentration of drainage by more than 5 times. Pure gas drainage effect is significant. Hydraulic fracturing enhanced permeability can improve the connectivity between coal pores, reduce the effective stress of the coal body, and increase the permeability of the coal seam. Through engineering tests, a set of hydraulic fracturing enhanced permeability technologies suitable for the low permeability combination rock coal seam of the mine have been formed. It is of great significance to guarantee the safe production of the mine.
Influence of temperature history on calcium leaching resistance of hydraulic concrete
Authors: Na Binbin , Yan Bin
Published: July 2021

In order to find out how temperature history affect leaching resistance, the leaching depths and compressive strength loss rate of pastes under three different temperature histories have been studied, the result shows that, with the progress of leaching, the compressive strength of samples continue to decrease, but the rate of decrease gradually slows down, and the leaching resistance of temperature match curing cured sample is better than that of standard curing cured, while the leaching resistance of circadian cycle curing cured sample is worse than that of standard curing cured.
Analysis and application of stress distribution in 24-m high bench loosening blasting with axially uncoupled charge structure in Barun Open-pit Mine
Authors: Yin Zuoming , Wang Xuguang , Wang Desheng , Dang Zhiheng , Bi Jiahao
Published: July 2021

The Barun Open-pit Mine has formed a 2-benches or 4-benches parallel mining condition due to the steep end-slope mining. In the enlarging process, the operation safety conditions of equipment are poor. In order to improve the operating conditions, increase the efficiency of slope enlarging, and reduce the mining cost, a technical solution is proposed that uncoupling the top air-deck charge structure by loosening blasting in the 24-m high bench. Based on the Holmquist-Johnson-Cook (HJC) constitutive model, the physical mechanism of the stress wave attenuation in the rock is analyzed. Considering the attenuation, reflection, transmission, and superposition of the pressure produced by the charge, the stress of any point in the rock medium is calculated. Furthermore, the rock state at that point is judged. The results show that the top air-deck reduces the stress at the top of the slope. Although the top resistance line is smaller than the bottom of the slope, with the top air-deck, the rock stress state at the top of the slope is not much larger than the bottom charge section, which makes the rock loose and does not produce a throwing phenomenon. After blasting, the muck pile has a good shape. The top air-deck charge structure has obvious effects in loose blasting, which provides a practical exploration for the slope enlarging of high benches in open-pit mines.
Nuclear Magnetic Resonance Experiment of Fluid Redistribution During the Gas Well Gap
Authors: Li Yao , Xu Tonghao , Zhai Shuo
Published: July 2021

In the actual production process of oil and gas reservoirs, the study of the redistribution characteristics of reservoir fluids is of great significance to the optimization of the indirect working system. Based on the nuclear magnetic resonance experiment, this paper analyzes the re-distribution of fluids in the core under the conditions of different shut-in times and different shut-in times. The distribution characteristics were studied. The results show that the water content increases with the increase of shut-in time and the number of shut-in times. For the same core, the water content in the large pores changes significantly.
Evaluation of Information Security of Deep Foundation Pit Reinforcement Scheme
Authors: He Xiaoling , Xu Chunjie , Guo Fang
Published: July 2021

The purpose of deep foundation pit support is to protect the safety of the underground structure and the surrounding environment. This article introduces the reinforcement measures of the deep foundation pit supporting structure in combination with a deep foundation pit on the Huzhou-Hangzhou line; from the material and mechanical point of view, the feasibility of the safe implementation of the deep foundation pit reinforcement plan is analyzed; then the displacement monitoring data obtained confirms that the reinforcement plan can be Improve the overall stability of the deep foundation pit construction, and provide safe and effective guidance for the deep foundation pit construction.
The Effect of Soft Rock and Sand Compound on Soil Nutrient and Environment Enzyme Activity
Authors: Hua Dongwen , Li Juan , Wang Jian
Published: July 2021

In order to study the improvement effect of the Mu Us sandy land in northern Shaanxi, this paper takes the Xiaojihan land improvement project in Yulin City as the research background, and sets up the experiment of 3 kinds of soft rock and sand compound ratios (1:1, 1:2, 1:5) In the plot, statistical analysis methods were used to compare the physical and chemical properties of soil and soil enzyme activities under different treatments. The results show that the addition of soft rock has a significant effect on soil texture and available nutrients, and it increases with the increase of soft rock content. Compared with the original sandy land, the content of water-stable aggregates (<0.25) increases by 42.3%, which is quick-acting the phosphorus content was increased by 89.9%, the available potassium content was increased by 22.3%, and the enzyme activity of the cultivated soil was significantly improved. Among them, the correlation between soil phosphatase and the physical and chemical properties of the soil is relatively high, and it can be used as a measure for judging the fertility of the compound soil index.
Impact of Land and Soil Types Change on Precipitation Infiltration Recharge in Baiquan Spring Basin
Authors: Wang Xiaobo , Shu Longcang , Wang Xin , Dong Yanan , Onan Yao Kouassi Bienvenue Mikael , Ni Hanxi
Published: July 2021

To study the impact of land types change on precipitation infiltration recharge in Baiquan spring basin of Jinan City, the remote sensing monitoring data of land use in 1980, 1990, 2000 and 2018 were selected to analyze the change trend of land types. Based on FEFLOW software, the groundwater flow numerical model of the study area is constructed to analyze the variation of precipitation infiltration recharge in different periods. The results show that: the urban land area expanded rapidly from 1980 to 2018, mainly occupied arable land and woodland, and the urbanization rate in 2018 was 17.18%. In 2018, the precipitation infiltration recharge is 15497.92 × 104 m3/a, 17.20% less than that in 1980. The research results can provide theoretical support and decision-making basis for the urban planning and the sustainability and protection of spring basin.
Numerical Simulation Research on the Displacement of Ground Connecting Wall in Geological Excavation and Soil Remediation
Authors: You Hongyue , Wang Qingbiao , Wang Hui , Liu Junpeng , Zhao Yenan , Tian Yuanyuan , Yang Shuo , Jiang Yanbo
Published: July 2021

Monitoring the changes of the retaining pile wall during the excavation of the deep foundation pit, and accurately grasping the side displacement changes of the retaining pile wall can effectively grasp the safety status of the foundation pit construction. In this paper, taking Guangfo Ring Road as an example, theoretical analysis, numerical simulation and other methods are used to study the influence of foundation pit excavation on the horizontal displacement and deformation of the ground connecting wall during the reinforcement of mixed piles in the area adjacent to high-rise buildings. Get the following conclusion : (1) With reinforced ground connecting walls and non-reinforced ground connecting walls, the horizontal displacement curve of ground connecting walls is roughly the same, showing a trend of change between the larger and the smaller ends. As the excavation depth continues to increase, the changing trend of the “bow” becomes more obvious, which is in line with the changing law of the enclosure structure. (2) After the mixing pile is used for reinforcement, the maximum horizontal displacement of the ground connecting wall is greatly reduced. Compared with the case without reinforcement measures, the horizontal displacement value of the ground connecting wall is 5.66mm, which is reduced by 6.23mm. The reduction ratio is 52%, indicating that the mixing pile has a great inhibitory effect on the horizontal displacement of the ground connecting wall. (3) By comparing on-site monitoring and numerical calculation data, the change trend of the wall horizontal displacement of the measured value and the simulated value is approximately the same. The measured maximum value of the monitoring section is 8.46mm, the simulated maximum value is 5.66mm, and the difference between the two is 2.8 mm, verified the rationality of the model, and provided some experience for the excavation of foundation pits to protect adjacent buildings.