bluuebunny/crossref_metadata_2025 huggingface dataset:
Early Surgical Intervention for Active Thoracic Spinal Tuberculosis with Paraplegia
Authors: Li Weiwei , Liu Zheng , Xiao Xiao , Xu Zhenchao , Sun Zhicheng , Zhang Zhen , Wang Xiyang
Published: July 2020

Background: To explore the therapeutic effect of early surgical interventions for patients of active thoracic spinal tuberculosis (TB) with paraplegia. Methods: Data of 118 patients with active thoracic spinal TB and paraplegia who had undergone surgeries at an early stage (within three weeks of paraplegia) from January 2008 to December 2014 were retrospectively analyzed. The operation duration, blood loss, perioperative complication rate, VAS score, ASIA grade of neurological status, Erythrocyte Sedimentation Rate (ESR), C-reactive protein (CRP), kyphotic Cobb’s angle, and duration of bone graft fusion were analyzed to evaluate the therapeutic effects. Results: Mean operation time was 194.2 minutes, mean blood loss was 871.2 ml. The perioperative complication rate was 5.1%. Mean preoperative VAS score was 5.3, significantly decreased to 3.2 after operation, and continued decreasing to 1.1 at the follow up (P＜0.05). All cases achieved at least one grade elevation after operation, specifically, 2 cases of ASIA grade A rose to grade B, 10 cases of ASIA grade A rose to grade C, 2 cases of ASIA grade A rose to grade E; 9 cases of ASIA grade B rose to grade D, 38 cases of ASIA grade B rose to grade E; all 57 cases of ASIA grade C rose to ASIA grade E. The rate of full neurological recovery for complete paraplegia patients was 14.3%, significantly lower than the rate (91.3%) for incomplete paraplegia patients. Mean preoperative ESR and CRP were 73.1 mm /h and 82.4 mg/L, insignificantly increased after operation (P＞0.05), then gradually decreased to 11.5 ± 1.8 mm /h and 2.6 ± 0.82 mg/L at the final follow up, respectively (P＜0.05). The mean preoperative kyphotic Cobb’s angle was 21.9º, significantly decreased to 6.5º after operation (P＜0.05) and the kyphotic correction had not lost during the follow up (P＞0.05). Mean duration of bone graft fusion was 8.6±1.3 months Conclusion: Early surgical intervention may be beneficial for patients with active thoracic spinal TB with and paraplegia, with surgical intervention being more beneficial for incomplete paraplegic recovery compared with that of complete paraplegia.
Partnering with Patients to Get Better Outcomes with Chimeric Antigen Receptor T-cell Therapy: Towards Meaningful Patient Engagement in Early Phase Trials
Authors: Foster Madison , Fergusson Dean , Hawrysh Terry , Presseau Justin , Kekre Natasha , Schwartz Stuart , Castillo Gisell , Asad Sarah , Fox Grace , Atkins Harold , Thavorn Kednapa , Montroy Joshua , Holt Robert , Monfaredi Zarah , Lalu Manoj
Published: July 2020

Aim: Though patient engagement in clinical research is growing, recent reports suggest few clinical trials report on such activities. To address this gap, we describe our approach to patient engagement in the development of a clinical trial protocol for a new immunotherapy for blood cancer (chimeric antigen receptor T-cell therapy, CAR-T cell therapy). Methods: Our team developed a clinical trial protocol by working with patient partners from inception. Two patient partners with lived blood cancer experience were identified through referrals from our team’s professional network and patient organization contacts. Our patient partners were onboarded to the team and engaged in several studies conducted to develop the clinical trial protocol, including a systematic review of the existing literature on the therapy, patient interviews and a survey to obtain perspectives on barriers and enablers to participating in the trial, an early economic analysis, and a retrospective cohort study. Results: Engaging patient partners enhanced our research in ways that would not have otherwise occurred. By selecting patient important outcomes for data collection, our partners helped flag that quality of life and health utility measures have not been reported in previous CAR-T cell therapy trials for blood cancer. Our partners also co-developed a non-technical summary of the systematic review that summarized results in an accessible manner. Our patient partners reviewed interview and survey questions, to improve the language and appropriateness; provided recruitment suggestions; and provided a patient perspective on the results, thereby confirming the importance of findings. Input was also obtained on costs for the early economic analysis. Our patient partners identified costs that may be a burden to both patients and caregivers during a trial and helped to confirm that the overall structure of the economic model reflected the patient care pathway. Our patient partners also shared their diagnosis and treatment stories, which helped to provide the research team with insight into this experience.Conclusions: Contributions by our patient partners were invaluable to each component study, as well as the overall development of the trial protocol. We plan to use this approach in the future, to meaningfully engage patients in the development of other clinical trials; we also hope that by reporting our methods this will help other research teams to do the same. Trial Registration: Affiliated with the development of NCT03765177
MiR-221-5p Is Involved in the Regulation of Inflammatory Responses in Acute Gouty Arthritis by Targeting IL-1β
Authors: Li Guangwen , Zhang Huihui , Ma Hong , Qu Shiping , Xing Qian , Wang Ge
Published: July 2020

Background: Gout is caused by the accumulation of deposited sodium urate (MSU) crystals in the joints. Recent studies have shown that interleukin-1β (IL-1β) is a key inflammatory mediator of acute gouty arthritis(AGA), and its level is regulated by microRNAs (miRNAs). However, the molecular mechanism of its regulation is still unclear.Methods: 100 patients with AGA and 94 healthy individuals were recruited. The expression of serum miR-221-5p was determined by qRT-PCR. The receiver operating curve (ROC) was applied for diagnostic value analysis. A luciferase reporter assay was performed to confirm the interaction of miRNA and the 3'-untranslated region (UTR) of IL-1β. ELISA was used to detect serum and proinflammatory factors.Results: miR-221-5p was lower expressed in the serum of AGA patients. The AUC was 0.884, the sensitivity was 82.0%, and the specificity was 80.9%. Serum miR-221-5p was negatively correlated with the expression levels of VAS and IL-1β. Cell experiments showed that overexpression of miR-221-5p significantly inhibited the expression of inflammatory factors tumor necrosis factor-α (TNF-α), interleukin-8 (IL-8), and IL-1β, while down-regulation of miR-221-5p was the opposite. Luciferase analysis showed that IL-1β was the target gene of miR-221-5p.Conclusions: This study confirmed that miR-221-5p regulates the production of inflammatory cytokines during the pathogenesis of AGA. These results suggest that miR-221-5p can be used as potential therapeutic targets for the treatment of AGA.
Plasma Fibrinogen, D-dimer, and Fibrin Degradation Product as Biomarkers of Rheumatoid Arthritis
Authors: Xue Li , Li Ming , Tao Li , Li Xueyi , Wang Wei , Wang Yan , Wang Biao , Zhang Yanping , Gao Ning , Dong Yanying , Zhou Ting , Liu Zeshi , Liu Hailong , He Juntao , Li Ke , Geng Yan
Published: July 2020

Objective: This study aimed to assess the role of coagulation-related indicators such as plasma ﬁbrinogen (FIB), D-dimer, and fibrin degradation product (FDP) in rheumatoid arthritis (RA) and their association with disease activity.Methods: Data from 105 RA patients and 102 age- and gender- matched healthy controls were collected in the retrospective study. Disease activity score in 28 joints based on C-reactive protein (DAS28-CRP) was used to divide the RA patients into inactive group (DAS28-CRP ≤ 2.7) and active group (DAS28-CRP > 2.7). The association between plasma FIB, D-dimer, and FDP and DAS28-CRP was evaluated by spearman correlation. Receiver operating characteristic (ROC) curve was applied to determine the area under curve (AUC) value. The prognostic value of plasma FIB, D-dimer, and FDP in the RA disease activity was tested by logistical regression analysis.Results: RA patients showed higher FAR levels of plasma FIB, D-dimer, and FDP than the controls (P < 0.01). Plasma FIB, D-dimer, and FDP were also increased in active group of RA patients than those in inactive group (P < 0.001). Spearman analysis showed that plasma FIB, D-dimer, and FDP were positively related with DAS28-CRP (P < 0.001) in RA patients. ROC curve analyses revealed that the AUC of D-dimer was higher than ESR and RF, and that of FDP was higher than RF in RA patients. In addition, the optimal cut-oﬀ value of plasma FIB, D-dimer, and FDP for RA diagnosis was 286 mg/dL, 470 μg/L, and 1.45 mg/L, respectively. Logistical regression analyses showed that D-dimer (odds ratio = 2.862, 95% conﬁdence interval: 1.851-4.426, P < 0.001) was a predictor for RA disease activity.Conclusions: FIB, D-dimer, and FDP were increased in RA patients and positively correlated with the disease activity of RA. D-dimer may act as a novel inﬂammatory parameter for predicting disease activity in RA patients.
Clinical Value of Patlak Ki Images Extracted From Dynamic 18F-FDG PET/CT For Evaluation of The Relationships Between Disease Activity and Clinical Events in Cardiac Sarcoidosis
Authors: Nakajo Masatoyo , Ojima Satoko , Kawakami Hirofumi , Tani Atsushi , Hirayama Akira , Jinguji Megumi , Kubozono Takuro , Ohishi Mitsuru , Yoshiura Takashi
Published: July 2020

Background: Cardiac sarcoidosis (CS) has a poor prognosis because of frequent complication of atrioventricular block, ventricular tachycardia and congestive heart failure. Qualitative or quantitative 18F-FDG PET/CT has been used for diagnosing or assessing the disease activity of CS. However, the association between 18F-FDG myocardial uptake and clinical presentations in CS has not yet been clarified, and it is unknown if Patlak Ki images (Ki images) extracted from dynamic 18F-FDG-PET/CT are useful for evaluating the disease activity or clinical events in CS patients. In this context, this study was performed to investigate the usefulness of SUV and Patlak Ki images extracted from dynamic 18F-FDG-PET/CT for evaluating the risk of severe clinical events (SCEs) in CS. Methods: The SUV and Ki myocardial images were generated from 30 dynamic 18F-FDG-PET/CT scans of 21 CS patients including those with cardiac dysfunction and arrhythmic events. SUV parameters and Ki parameters (Ki max, Ki mean, Ki volume) were measured for positive myocardial lesions. The Mann–Whitney U-test or Fisher’s exact test was used appropriately to assess differences between quantitative variables or compare categorical data. The association between each quantitative parameter and presence of SCEs was analyzed by logistic regression analysis.Results: The SUV and Ki mages both were rated as positive in 19 scans and negative in 11 scans with the same incidence of SCEs which were significantly higher in positive than negative scans [cardiac dysfunction: 78.9% (15/19) vs. 27.2% (3/11), p=0.009; arrhythmic events: 65.5% (10/19) vs. 0% (0/11), p=0.004]. In 19 positive scans, neither SUV nor Ki parameters were significantly different between scans of patients with cardiac dysfunction (n=15) and those without (n=4) (p>0.05, each), whereas the three Ki parameters were significantly higher in scans for patients with arrhythmic events (n=10) than in those without (n=9) (p<0.05, each). Logistic regression analysis showed that the Ki volume alone was significantly associated with the risk of arrhythmic events (Odds ratio: 1.11, p=0.047).Conclusion: Patlak Ki images may add value to SUV images for evaluating the risk of SCEs in CS patients.
Prevalence of HPV Infection in Head and Neck Cancer Patients in Egypt: National Cancer Institute Experience.
Authors: Salem Doaa A. , Bahaa Sherif , Rouby Mahmoud N. El , Osman Yehia A. , Bahnassy Abeer A , Zekri Abdel-Rahman
Published: July 2020

Background: The new classification of Head and Neck Squamous Cell Carcinoma (HNSCC) according to their association with human papillomavirus (HPV) infection into HPV positive tumors with good prognosis and HPV negative tumors with poor prognosis has changed the treatment strategy of HNSCCs dramatically worldwide. However, data concerning HPV infection in HNSCCs patients is still limited and there are no studies regarding HPV genotypes in HNSCC among Egyptians. Therefore, the aim of the current study is to investigate the frequency of HPV and to detect the most prevalent HPV genotypes in the patients with oral cavity and oropharyngeal carcinoma from EgyptMethods: This cross sectional study was conducted from January 2016 to November 2017. Ninety-two oral brushing samples (76 oral cavity and 16 oropharynx) were collected by cytobrushing in CYTO-fast solution. HPV-DNA was subjected to two methods which are the: (1) HPV Direct Flow CHIP system for automatic detection and genotyping (2) conventional PCR for detection of HPV using consensus primers (MYO9/MYO11). SPSS software was used for statistical analysis.Results: Out of the 92 cases assessed, HPV DNA was present in three samples only (3/92; 3.3%) and the HPV66 genotype was the only genotype detected by HPV Direct Flow CHIP System.Conclusion: The Results of this study may (1) indicate that the HPV-associated HNSCC among Egyptian patients is very low and (2) highlight the presence of HPV66 genotype in these malignancies. Other studies from other countries in general and from different governorates in Egypt are still needed to determine the exact frequency of HPV infections in head and neck cancer.
Mechanical Thrombectomy of Large Vessel Occlusions in COVID-19 Related Stroke: Endovascular and Clinical Outcomes
Authors: Al-Smadi Anas S. , Abrol Srishti , Luqman Ali , Chamiraju Parthasarathi , Abujudeh Hani
Published: July 2020

Background and PurposeStroke is a drastic complication and a poor prognostic marker of COVID-19 disease which emphasizes the importance of early identification and management of this complication. In this case series, we describe our experience of mechanical thrombectomy of large vessel occlusions (LVO) in patients with COVID-19.MethodsWe performed a retrospective study of a series of confirmed COVID-19 patients who underwent endovascular thrombectomy for acute cerebrovascular ischemic disease with large vessel occlusion. Patient demographics, presentations, lab values, angiographic and clinical outcomes were also reviewed.ResultsThree COVID-19 patients with large vessel occlusion who underwent endovascular thrombectomy were identified in our multi-center institution. Two patients had respiratory symptoms prior presentation and one patient presented initially with clinical deficits. Two patients had anterior circulation occlusion in the middle cerebral artery territory vs one had posterior circulation occlusion in the basilar artery. There was good angiographic outcome post thrombectomy in all patients, however poor clinical outcomes noted with no significant improvement in neurological manifestations in comparison with baseline at presentation. All patients developed critically severe symptoms during hospitalization requiring intubation and one patient died of COVID-19 related respiratory failure.ConclusionIn this small case series, we noted worse clinical outcomes in COVID-19 related LVO stroke despite effective thrombectomy, which may be related to the underlying COVID-19 disease and/or the nature of clot in these patients.
Comparative Cost Analysis of Using Pedi-packs and Adult Red Cell Packs in Newborn Intensive Care Units in Southern Iran
Authors: Haghpanah Sezaneh , Miladi Shima , Zamani Ali , Abadi Ali Mohammad Keshtvarz Hesam , Gholami Marjan , gholami maryam
Published: July 2020

Background and objective:In most developing countries, blood transfusions are routinely administered by adult red blood cells (RBCs) packs in infants leading to wastage of a large amount of blood supplies as well as having high donor exposure risk. We aimed to compare the cost-effectiveness of hypothetical pediatric pack compared to adult RBCs pack in neonates.Methods: In this cross-sectional study, all transfused neonates (n = 70) who were admitted to the newborn intensive care unit (NICU) of Nemazee Hospital, a tertiary referral hospital in Shiraz, Southern Iran, were evaluated between March and June, 2019. Based on the blood bank information during the study period and transfusion indices, a specific pediatric pack was suggested and cost-effectiveness of new and traditional transfusion methods was compared.Results: Considering the mean number of transfusions per neonate: 3.57 and mean volume of transfused packed red cells: 20 ml per transfusion during the study period; a quadruple pediatric pack (240 ml divided in 4 sub-packs) was purposed and cost-analysis of pediatric and adult pack was performed. Mathematically, we proved higher cost-effectiveness in using pediatric versus adult pack. Additionally, using pediatric packs leads to 13.74% reduction in RBCs wastage per transfusion and 68.13% reduction in donor exposure rate.Conclusions: Assignment of dedicated pediatric pack for infants will be able to substantially reduce donor exposure risk as well as wasted resources leading to higher cost effectiveness. This finding should be taken into consideration especially in developing countries in order to promote both economic situation and child health status.
Temporal Hemiarthroplasty for Distal Femoral Osteosarcoma in Early Childhood: A Case Report
Authors: Imanishi Jungo , Tanabe Masayuki , Kurihara Taisei , Torigoe Tomoaki , Kikkawa Jun , Ota Atsuhiko , Watanabe Atsuko , Tanaka Ryuhei , Saita Kazuo , Kadono Yuho , Yazawa Yasuo
Published: July 2020

Background: Prosthetic reconstruction for distal femoral osteosarcoma is challenging for younger children. We herein report a successful case of limb-sparing surgery for a younger patient with distal femoral osteosarcoma requiring osteo-articular resection. Case Presentation: A 5-year-old girl with high-grade conventional osteosarcoma in the left distal femurunderwent a series of surgeries. After three cycles of neoadjuvant chemotherapy, limb salvage surgery was planned because femoral rotationplasty had been refused. At 6 years and 2 months old, distal femoral resection and temporary spacer insertion using a 7-mm-diameter intramedullary nail and molded polymethylmethacrylate was performed. At 7 years and 8 months old, secondary surgery was performed because the first spacer had been dislocated and the residual femur became atrophic. The distal end of the residual femur was removed by 1 cm, but the periosteum and induced membrane around polymethylmethacrylate was preserved. In order to stabilize the spacer against the tibia, a custom-made ceramic spacer with a smooth straight 8-mm-diameter stem was utilized. The bone-spacer junction was fixed with polymethylmethacrylate, and then covered with the preserved periosteum and induced membrane. After surgery, the bone atrophy improved. At 9 years and 7 months old, the second spacer was removed because it had loosened, and the knee joint was reconstructed using a custom-made growing femoral prosthesis with a curved porous 8.5-mm-diameter stem. Cancellous bone tips from the proximal tibia were grafted around the bone-prosthesis junction underneath the induced membrane. At 10 years and 5 months old, the patient was able to walk unsupported and a radiograph showed further thickening of the cortex of the residual femur without any stress shielding. Although having 5 cm of limb length discrepancy, the patient and her mother were satisfied with the function. The MSTS score was 24 out of 30 points. Repeated limb length extensions are planned.Conclusions: This case report provides an example of limb salvage surgery after distal femoral resection in a small child. The use of a temporary spacer utilizing partial cementation and preservation of the periosteum and induced membrane appears to afford a viable limb-salvage option after distal femoral resection for younger children.
Clinical Results Of A Lamina With Spinous Process And An Iliac Graft As Bone Grafts In The Surgical Treatment Of Single-Segment Lumbar Pyogenic Discitis: A Retrospective Cohort Study
Authors: Zhong Weiyang , Liang Xinjie , Wang Xiaolin , Tang Ke , Huang Tianji , Luo Xiaoji , Quan Zhengxue , Jiang Dianming
Published: July 2020

Background: A retrospective study investigated and compared the results of a lamina withspinous process (LSP) and an iliac graft (IG) as bone grafts in single-segment lumbar pyogenic discitis (LPD) through one-stage-posterior-only approach with radical debridement and internal instrumentation.Methods: Data from 37 patients were reviewed. A LSP was placed in 17 patients (group A), and an IG was implemented in 20 patients (group B). The surgery time, surgery hemorrhage, hospital stay, drainage, and follow-up (FU) were reviewed. The visual analogue scale (VAS), Oswestry Disability Index (ODI), erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) level, segmental angle, intervertebral height and bony fusion time were compared preoperatively and at the final FU.Results: All patients were followed-up for a mean of 27.94±2.35 months in group A and 30.29±1.89 months in group B, without a difference. The mean age was younger in group A than in group B (P<0.05). The surgery time, surgery hemorrhage, and hospitalization cost were lower in group A than in group B (P<0.05), except for the hospital stay and drainage time. Fever occurred in 10 patients in group A and 12 patients in group B. The ESR, CRP level, and VAS and ODI scores were significantly decreased, and there were no significant differences between the groups at the final FU. The distribution of bacterial agents in blood culture was 1 case of Aerobacter cloacae, 2 of Staphylococcus aureus, 2 of Escherichia coli, and 1 of Streptococcus viridis in group A and 1 of S. aureus，1 of Staphylococcus warneri and 2 of Klebsiella pneumoniae in group B. Pyogenic infection was observed in the pathological findings of all patients. No significant difference was found in the mean segmental angle or mean intervertebral height preoperation and at the final FU between the groups.Conclusion: The use of LSP as a new bone graft is reliable, safe, and effective for surgical management for the LPD while surgery is proposed as a good management strategy for LPD in carefully selected patients.
Covid-19 Pandemic: ARIMA and Regression Model based Worldwide Death Cases Predictions
Authors: Chaurasia Vikas , Pal Saurabh
Published: July 2020

Covid-19 has now taken a frightening form. As the day passes, it is becoming more and more widespread and now it has become an epidemic. The death rate, which was earlier in the hundreds, changed to thousands and then progressed to millions respectively. If the same situation persists over time, the day is not far when the humanity of all the countries on the globe will be endangered and we yearn for breath. From January 2020 till now, many scientists, researchers and doctors are also trying to solve this complex problem so that proper arrangements can be made by the governments in the hospitals and the death rate can be reduced. The presented research article shows the estimated mortality rate by the ARIMA model and the Regression model. This dataset has been collected precisely from DataHub-Novel Coronavirus 2019 - Dataset from 22nd January to 29th June 2020. In order to show the current mortality rate of the entire subject, the correlation coefficients of attributes (MAE, MSE, RMSE and MAPE) were used, where the average absolute percentage error validated the model by 99.09%. The ARIMA model is used to generate auto_arima SARIMAX results, auto_arima residual plots, ARIMA model results, and corresponding prediction plots on the training data set. These data indicate a continuous decline in death cases. By applying a regression model, the coefficients generated by the regression model are estimated, and the actual death cases and expected death cases are compared and analyzed. It is found that the predicted mortality rate has decreased after May 2, 2020. It will learn help the government and doctors prepare for the next plans. Based on short- period predictions these methods can use forecast for long- period.
CircRNA_0092516 regulates chondrocyte proliferation and apoptosis in osteoarthritis through the miR-337-3p/PTEN axis
Authors: Huang Zhihui , Ma Wenming , Xiao Jinhuai , Dai Xiaoyu , Ling Weiqi
Published: July 2020

Background
The dysregulation of circular RNAs (circRNAs) has been identified in various human diseases. Here, we mainly investigated the potential mechanism of circRNA_0092516 in osteoarthritis (OA).
Methods
The expression of circRNA_0092516 was detected by quantitative real-time PCR. MTT, flow cytometry, and Western blot were used to confirm the functions of circRNA_0092516 in vitro. Besides, RNA pull-down and dual-luciferase reporter gene experiments were used to study the potential mechanism.
Results
circRNA_0092516 was up-regulated in the tissues of OA patients and chondrocytes stimulated by IL-1β. The potential mechanism analysis revealed that circRNA_0092516 bound to miR-337-3p, and the interference with circRNA_0092516 promoted chondrocyte proliferation and repressed cell apoptosis through the miR-337-3p/PTEN axis, thereby improving OA.
Conclusions
Overall, our data showed that the interference with circRNA_0092516 promoted chondrocyte proliferation and repressed cell apoptosis through the miR-337-3p/PTEN axis, eventually slowed down the progress of OA.
Patients with COVID-19 Interstitial Pneumonia Exhibit Pancreatic Hyperenzymemia and Not Acute Pancreatitis
Authors: Pezzilli Raffaele , Centanni Stefano , Mondoni Michele , Rinaldo Rocco F. , Davì Matteo , Stefanelli Rossana , d’Eril GianVico Melzi , Barassi Alessandra
Published: July 2020

Background and aims: Gastrointestinal manifestations of COVID-19 have been well established, but pancreatic involvement is under debate. The aim of the study is to evaluate the presence of acute pancreatitis in COVID-19 patients and to assess the frequency of pancreatic hyperenzymemia. Methods: From April 1st 2020 to April 30th 2020, 110 consecutive patients (69 males, 41 females; mean age 63.0 years, range 24-93 years) met these criteria and were enrolled in the study.. The clinical data and serum activity of pancreatic amylase and lipase were assayed in all patients using commercially available kits. Results: None of the patients studied developed clinical signs or morphological alterations compatible with acute pancreatitis. However, it was found that 24.5% of the patients had amylase values above 53 IU/L and 16.4% had lipase values above 300 IU/. Only one patient (0.9%) had both amylase and lipase values in excess of three-fold the upper normal limit without clinical signs of pancreatitis. Conclusions: The presence of pancreatic hyperenzymemia in a patient with COVID-19 requires the management of these patients be guided by clinical evaluation and not merely by evaluation of the biochemical results.
ÜÇ MAHALLE, BİR SAYIM: 1845 TEMETTUAT DEFTERLERİ ÜZERİNDEN BURSA’NIN ÜÇ MAHALLESİNİN SOSYOEKONOMİK DURUMLARININ İNCELENMESİ
Authors: YETİŞİR Zeynep
Published: July 2020

Bu makale 1845 tarihli Temettuat Defterleri üzerinden Bursa’nın üç mahallesinin ekonomik ve sosyal durumlarını incelemeyi amaçlamaktadır. Tarihsel bir veri olarak Temettuat defterlerinin Osmanlı ekonomik ve sosyal tarihi konusunda araştırmacıya sunacağı imkânları doğru bir şekilde değerlendirmek için tahrirlerin yapılış amacının bilinmesi gereklidir. Bu nedenle çalışma öncelikle Temettuat tahrirlerini ait olduğu tarihsel bağlama yerleştirmekle işe başlayacaktır. Akabinde defterlerin muhtevası hakkında kısa bir bilgi verilecektir. Takip eden bölüm bahsi geçen defterlerin Osmanlı Devleti’nin sosyal ve ekonomik tarihi açısından ehemmiyeti ve araştırmacıya sunacağı imkânlar üzerinedir. Çalışmada son olarak Bursa’nın Müslüman, Ermeni ve Rum nüfustan oluşan Timurtaş Paşa, Veled-i Kurt ve Bulgarlar mahalleleri ilgili defterlerde yer alan veriler doğrultusunda demografik, ekonomik ve sosyal durum açılarından karşılaştırmalı olarak analiz edilecektir.
Removal of wastewater phenolic compounds with triethylenetetramine functionalized polystyrene resin
Authors: Teng Qiaoqiao , Ma Shufeng , Ni Mengyi , Liu Jiang , Yang Jinlei , Zhang Dianhong , Meng Qi
Published: July 2020

A polyamine functionalized polystyrene resin (PSATA) was prepared via condensation reaction of acetylated polystyrene resin with triethylenetetramine, which, upon NaBH4 reduction, produced PSATAR. In comparison with the PSATA, the PSATAR with more flexible amine groups shows improved structural properties, and the equilibrium adsorption capacities of phenol, 2-nitrophenol (ONP) and 2,4-dinitrophenol (DNP) in wastewater were up to 1.073, 1.832 and 1.901 mmol/g, respectively. Their adsorption isotherms fit well with the Freundlich model, indicating a multilayer, heterogeneous adsorption nature. Kinetic studies indicated that the adsorption of phenolic compounds conforms to the pseudo-second-order kinetics with the adsorption rate controlled by film diffusion for ONP and DNP, and intra-particle diffusion in the later stage for phenol.
Estrés postraumático y aptitudes de emprendimiento y resiliencia en mujeres víctimas del conflicto armado
Authors: Pérez-Correa Kethy Luz , Rodríguez-Vega Oscar Eduardo , Linero-Gómez Belia Elena
Published: July 2020

El presente artículo tiene por objeto explorar la relación existente entre el estrés postraumático y las aptitudes de emprendimiento y resiliencia en mujeres víctimas del conflicto armado en cinco municipios del departamento de Magdalena, Colombia. El diseño de la investigación es no experimental, transversal y de campo. La población objeto de estudio fue de 241 mujeres víctimas del conflicto armado, con emprendimientos en desarrollo empresarial y social. En los resultados se observó que la resiliencia en las mujeres emprendedoras del Magdalena se asume como la capacidad de sobreponerse y enfrentar las situaciones adversas. Por otro lado, se encontró que mediante el emprendimiento se promueve la competitividad a nivel personal, familiar y social teniendo en cuenta estrategias de colectividad y trabajo en equipo de la comunidad. Sin embargo, persisten muchas problemáticas para lograr la efectividad deseada. En términos de conclusiones, se hace énfasis en la necesidad de articular esfuerzos de diversos sectores que contribuyan a mejorar las condiciones de las mujeres víctimas del conflicto armado.
Desarrollo turístico desde el concepto de ciudad-puerto, caso Barranquilla, Colombia
Authors: Ospina-Arias Juan Carlos , Díaz-Solano Beatriz Helena , Yi-Rodriguez Jaime de Jesús
Published: July 2020

Este artículo muestra los resultados del estudio sobre el potencial turístico de Barranquilla (Colombia), desde el contexto portuario. Metodológicamente se realizaron 392 encuestas con el fin de evaluar la identidad de la población con el río Magdalena y su capacidad para construir el concepto colectivo de ciudad-puerto. Se diseñaron escenarios prospectivos por medio de la técnica de grupos focales. En el escenario a 10 años, se visualiza la creación de una autoridad portuaria como principal avance. En el escenario a 20 años, se destaca la planeación a largo plazo y el afianzamiento del concepto de ciudad-puerto a través del desarrollo de la infraestructura, la logística y el turismo. Para un escenario a 30 años se proyecta un e-port, puerto y ciudad, integrado en su logística y operaciones por las TIC. Entre las conclusiones se destaca que el ciudadano barranquillero presenta una barrera de identificación con el río y con la apropiación del concepto relacional de ciudad-puerto como el principal motor de desarrollo socioeconómico; se identifica la dificultad para construir ideas conjuntas entre el desarrollo turístico-portuario en el contexto ciudad-puerto.
Comportamiento del consumidor de productos en la oferta de tribu inga
Authors: Vergel-Ortega Mawency , Paz-Montes Luisa Stella , Rojas-Suárez Jhan Piero
Published: July 2020

La investigación sigue un enfoque mixto. Su objetivo es diseñar un modelo estructural que identifique variables explicativas del proceso de compra de artesanías y extractos de plantas medicinales a la comunidad inga. Desde el método etnográfico en investigación cualitativa, y utilizando elementos del diseño factorial y correlacional, basado en el modelo de ecuaciones estructurales (SEM) del enfoque cuantitativo, se implementan instrumentos de entrevista, observación y encuesta a una muestra constituida por 500 transeúntes consumidores de productos naturales y 280 integrantes de la comunidad inga del municipio de Cúcuta, Colombia. Los resultados permiten identificar categorías emergentes como planeación territorial participativa, contexto, igualdad de derechos, producción sustentable, organización, investigación e innovación, mercadeo y capacitaciones como inversión natural; así mismo, dentro de una inversión ambiental, factores de capacidad de talento humano, uso de prácticas ancestrales, factores sociales, producto, afecto y tecnología inciden en el comportamiento del consumidor como irrupción del orden social. Se concluye que a partir del modelo logit se identifica la representación cultural influida por el comportamiento del consumidor de productos en la oferta de las tribus.
Estimated Arterial Stiffness and Prediction of Vascular Aging: The Rising of a New Era
Authors: Antza Christina , Doundoulakis Ioannis , Akrivos Evangelos , Stabouli Stella , Chrysaidou Katerina , Gidaris Dimos , Kotsis Vasilios
Published: July 2020

Arterial stiffness has been associated with cardiovascular events and correlated with cardiovascular
risk factors. In the new guidelines of the European Society of Hypertension, the evaluation
of arterial stiffness, and specifically carotid-femoral pulse wave velocity (c-f PWV), was taken
into account for the detailed screening of the hypertensive population. Despite the importance of
arterial stiffness as a target organ damage, the measurement is time-consuming, not practical, needs
expensive equipment and experienced staff. For all these reasons, c-f PWV is not recommended for
the everyday clinical practice and its current use is restricted for research purposes. The importance
of arterial properties in clinical practice and cardiovascular prevention is well known. Hence, the
estimation of arterial stiffness and vascular health based on parameters that affect arterial stiffness,
but without the use of a machine, is a new promising field. Furthermore, the relationship between
age-related MRI abnormalities as well as ultrafast ultrasound with vascular effect gives a new promise
for future vascular aging assessment.
Host-directed Therapy: A New Arsenal to Come
Authors: Mohan Mradul , Bhattacharya Debapriya
Published: July 2020

The emergence of drug-resistant strains among the variety of pathogens worsens the
situation in today’s scenario. In such a situation, a very heavy demand for developing the new
antibiotics has arisen, but unfortunately, very limited success has been achieved in this arena till
now. Infectious diseases usually make their impression in the form of severe pathology.
Intracellular pathogens use the host’s cell machinery for their survival. They alter the gene
expression of several host’s pathways and endorse to shut down the cell’s innate defense pathway
like apoptosis and autophagy. Intracellular pathogens are co-evolved with hosts and have a striking
ability to manipulate the host’s factors. They also mimic the host molecules and secrete them to
prevent the host’s proper immune response against them for their survival. Intracellular pathogens
in chronic diseases create excessive inflammation. This excessive inflammation manifests in
pathology. Host directed therapy could be alternative medicine in this situation; it targets the host
factors, and abrogates the replication and persistence of pathogens inside the cell. It also provokes
the anti-microbial immune response against the pathogen and reduces the exacerbation by
enhancing the healing process to the site of pathology. HDT targets the host’s factor involved in a
certain pathway that ultimately targets the pathogen life cycle and helps in eradication of the
pathogen. In such a scenario, HDT could also play a significant role in the treatment of drugsensitive
as well with drug resistance strains because it targets the host’s factors, which favors the
pathogen survival inside the cell.
Quetiapine Fumarate Loaded Nanostructured Lipid Carrier for Enhancing Oral Bioavailability: Design, Development and Pharmacokinetic Assessment
Authors: Agarwal Shweta , HariKumar S.L. , Negi Poonam , Upadhyay Navneet , Garg Rajeev
Published: July 2020

Aims:

The study aimed at developing and characterizing Nanostructured Lipid Carriers (NLC)
of Quetiapine Fumarate (QF) by Design of Experiment (DoE) for the enhancement of bioavailability.

Background:

QF, an anti-psychotic drug, has an oral bioavailability of 9% due to hepatic first- pass
metabolism necessitating the use of high doses. Its side effects are dose -related and enhancement in
bioavailability would result in minimization of side effects.

Objective:

The objective of the study was the enhancement of bioavailability of the NLC of QF by preferential
lymphatic uptake.

Methods:

Hot emulsification-ultrasonication was the method of formulation using PrecirolATO5 and
Oleic acid as solid and liquid lipids respectively. Poloxamer188 and Phospholipon90G were used as
surfactant and stabilizer respectively. Solid:liquid lipid ratio and Phospholipon90G amount were independent
variables and percent Entrapment Efficiency (%EE), Particle Size (PS) dependent variables
during optimization by Central Composite Design.

Results:

The optimized formulation showed a %EE of 77.21%, PS of 140.2 nm and surface charge of -
19.9mV. Higuchi kinetic model was followed during the in-vitro release. TEM revealed spherical,
smooth nanoparticles. A pharmacokinetic study in rats showed AUC0-∞ of QF-NLC to be 3.93 times
that of QF in suspension, suggesting significant enhancement in bioavailability. An increase in AUC0-∞
in cycloheximide untreated rats’ group of QF-NLC by 2.43 times as compared to cycloheximide treated
group, confirmed lymphatic absorption of QF- NLC.

Conclusion:

The results validated DoE as an appropriate tool for developing QF loaded NLC and
proved NLC to be a promising delivery system for the enhancement of oral bioavailability of QF.
Apoptotic Effects of N-(2-Hydroxyphenyl)-2-Propylpentanamide on U87-MG and U-2 OS Cells and Antiangiogenic Properties
Authors: Castillo-Juárez Paola , Sanchez Sebastián C. , Chávez-Blanco Alma D. , Mendoza-Figueroa Humberto L. , Correa-Basurto José
Published: July 2020

Background and Objective:

Histone Deacetylases (HDACs) are important therapeutic targets for
many types of human cancers. A derivative of valproic acid, N-(2-hydroxyphenyl)-2-propylpentanamide (HOAAVPA),
has antiproliferative properties on some cancer cell lines and inhibits the HDAC1 isoform.

Materials and Methods:

In this work, HO-AAVPA was tested as an antiproliferative agent in U87-MG (human
glioblastoma) and U-2 OS cells (human osteosarcoma), which are types of cancer that are difficult to treat, and its
antiangiogenic properties were explored.

Results:

HO-AAVPA had antiproliferative effects at 48h with an IC50=0.655mM in U87-MG cells and an
IC50=0.453mM in U-2 OS cells. Additionally, in the colony formation assay, HO-AAVPA decreased the number
of colonies by approximately 99% in both cell lines and induced apoptosis by 31.3% in the U-2 OS cell line and
by 78.2% in the U87-MG cell line. Additionally, HO-AAVPA reduced the number of vessels in Chorioallantoic
Membranes (CAMs) by approximately 67.74% and IL-6 levels in both cell lines suggesting that the biochemical
mechanism on cancer cell of HO-AAVPA is different compared to VPA.

Conclusion:

HO-AAVPA has antiproliferative effects on glioblastoma and osteosarcoma and antiangiogenic properties.
Are There Optimal Forms of Public-Private Partnerships?
Authors: Karnes Yi
Published: July 2020

Many emerging economies have launched ambitious efforts to privatize state-owned enterprises (SOEs). However, not all privatization entails complete ownership and control transfer from public to private hands. In this study, we recognize different forms of public-private partnerships in investment projects in emerging economies. We conceptualize these organization forms as different ownership and control by SOEs and private entities. Integrating transaction cost economics (TCE), agency theory, and institution-based view; we propose that public-private partnership forms are interdependent with characteristics of private entities and institutional environments. We find that there are optimal forms of partnerships that benefit the performance of public-private investments.
Scenario-Based Training for Sexual Harassment Prevention
Authors: Desplaces David , Ogilvie John
Published: July 2020

Although laws have been enacted both to prevent sexual harassment (SH) and to prosecute those who engage in it, the issue remains a matter of concern in the workplace. A variety of training programs have been developed to address SH, but their effectiveness has been called into question. Using a scenario-based activity, we directly assessed the impact of various training approaches on undergraduate and graduate students’ perceptions of SH. A comparison of pre- and post-measures indicated that the scenario and associated activities yielded post-session shifts in awareness of SH. Differences were found between undergraduate men and women and between undergraduates and graduates, with no gender differences observed among the latter.
Влияние диффузионных барьеров на емкостные свойства композитных анодов состава Si-CuSi-Cu
Authors: Бучин Э.Ю. , Мироненко А.А. , Наумов В.В. , Рудый А.С.
Published: July 2020

As an anode material for liquid lithium-ion batteries, film structures consisting of several identical modules [Co(x)/a-Si(100)/Cu(70)], where the value of x varied from 2 to 10 nm, have been studied. It is shown that relatively thick cobalt layers are effective diffusion barriers for silicon and copper atoms, as well as lithium ions. This leads to a decrease in the capacitive properties of the studied films. Thin cobalt layers (less than 3 nm) with a network structure, on the contrary, contribute to an increase in the capacitive properties of anode films. This is due to a more uniform distribution in their volume of drift channels of lithium ions, which are formed at the initial stage of electrode cycling.
Волноводные логические вентили для магнитооптических кубитов
Authors: Эгамов Ш.В. , Хидиров А.М. , Уринов Х.О. , Жуманов Х.А.
Published: July 2020

Results of magneto-optical waveguide logic gates properties investigation are presented. Simple logic operations can be realized using photon properties in modulated magnetic field. Changing the magnetic field amplitude and its orientation relating to light propagation direction, choosing polarizer and analyzer orientation and proper waveguide geometry, we can design logic gates avoiding small coherence time of regular optic qubits.
Использование высокочастотной шумоподобной модуляции для снижения дрейфовых процессов в LiNbO-=SUB=-3-=/SUB=--фазовом модуляторе волоконно-оптического гироскопа
Authors: Востриков Е.В. , Погорелая Д.А. , Никитенко А.Н. , Алейник А.С.
Published: July 2020

In this paper, the phase modulator optical phase drift reduction method is proposed and researched for LiNbO3 multi-functional integrated optical chip as a part of a fiber-optic gyroscope. This approach consists of applying a very high-frequency noise signal to a phase modulator in the range from 20 MHz to 100 MHz, which is outside of a fiber-optic gyroscope operating frequency range. The presented method showed that the increase in very high-frequency noise signal voltage up to around 1.7 half-wave voltages of the phase modulator allows decreasing optical phase drift by more than 4 times in the frequency range below 64.5 kHz.
The Internet Hospital as a Telehealth Model in China: Systematic Search and Content Analysis
Authors: Han Yangyang , Lie Reidar K , Guo Rui
Published: July 2020

Background

The internet hospital is an innovative organizational form and service mode under the tide of internet plus in the Chinese medical industry. It is the product of the interaction between consumer health needs and supply-side reform. However, there has still been no systematic summary of its establishment and definition, nor has there been an analysis of its service content.

Objective

The primary purpose of this study was to understand the definition, establishment, and development status of internet hospitals.

Methods

Data on internet hospitals were obtained via the Baidu search engine for results up until January 1, 2019. Based on the results of the search, we obtained more detailed information from the official websites and apps of 130 online hospitals and formed a database for descriptive analysis.

Results

By January 2019, the number of registered internet hospitals had expanded to approximately 130 in 25 provinces, accounting for 73.5% of all provinces or province-level municipalities in China. Internet hospitals, as a new telehealth model, are distinct but overlap with online health, telemedicine, and mobile medical. They offer four kinds of services—convenience services, online medical services, telemedicine, and related industries. In general, there is an underlying common treatment flowchart of care in ordinary and internet hospitals. There are three different sponsors—government-led integration, hospital-led, and enterprise-led internet hospitals—for which stakeholders have different supporting content and responsibilities.

Conclusions

Internet hospitals are booming in China, and it is the joint effort of the government and the market to alleviate the coexistence of shortages of medical resources and wasted medical supplies. The origin of internet hospitals in the eastern and western regions, the purpose of the establishment initiator, and the content of online and offline services are different. Only further standardized management and reasonable industry freedom can realize the original intention of the internet hospital of meeting various health needs.