bluuebunny/crossref_metadata_2025 huggingface dataset:
Detection of Fusobacterium nucleatum in feces and colorectal mucosa as a risk factor for colorectal cancer: a systematic review and meta-analysis
Authors: Janati Amal Idrissi , Karp Igor , Laprise Claudie , Sabri Hisham , Emami Elham
Published: December 2020

Background

Colorectal cancer (CRC) is a major cause of cancer deaths worldwide. Accumulating evidence suggests a potentially important role of colorectal infection with Fusobacterium nucleatum (F. nucleatum) in colorectal carcinogenesis. We conducted a systematic review, including both a qualitative synthesis and a meta-analysis, to synthesize the evidence from the epidemiological literature on the association between F. nucleatum detection in the colon/rectum and CRC.

Methods

A systematic literature search of Ovid MEDLINE(R), Embase, Web of Science Core Collection, EBM Reviews—Cochrane Database of Systematic Reviews, and CINAHL Plus with Full Text was conducted using earliest inclusive dates up to 4 October 2020. Eligible studies were original, comparative observational studies that reported results on colorectal F. nucleatum detection and CRC. Two independent reviewers extracted the relevant information. Odds ratio (OR) estimates were pooled across studies using the random effects model. Newcastle-Ottawa scale was used to critically appraise study quality.

Results

Twenty-four studies were included in the systematic review, of which 12 were included in the meta-analysis. Studies investigated F. nucleatum in feces, colorectal tissue samples, or both. In most studies included in the systematic review, the load of F. nucleatum was higher, on average, in specimens from CRC patients than in those from CRC-free controls. Meta-analysis showed a positive association between F. nucleatum detection in colorectal specimens and CRC (OR = 8.3; 95% confidence interval (95% CI) 5.2 to 13.0).

Conclusions

The results of this systematic review suggest that F. nucleatum in the colon/rectum is associated with CRC.

Systematic review registration

This systematic review protocol has been registered with the International Prospective Register of Systematic Reviews (PROSPERO) on July 10, 2018 (registration number CRD42018095866).
Diagnosis and therapy of functional tremor a systematic review illustrated by a case report
Authors: Bartl Michael , Kewitsch Rebekka , Hallett Mark , Tegenthoff Martin , Paulus Walter
Published: December 2020

Background

Diagnosis of functional movement disorders and specifically functional tremor (FT) (representing 50% of them) remains demanding. Additionally, due to heterogeneity of the disorders, structured concepts and guidelines for diagnosis and therapy are difficult to establish. Ascertaining the state of knowledge to derive instructions for operating procedures is the aim of this review.

Main text

Based on a standardized systematic literature research using the term “psychogenic tremor” in the MEDLINE database dating back ten years, 76 studies were evaluated. Conventional features of FT are variability of frequency and amplitude. Further, response to distraction by motor and cognitive tasks is a key diagnostic feature in differentiation between organic and functional origin. A variety of electrophysiological tests have been evaluated including surface electromyography and accelerometry to establish laboratory-supported criteria for diagnosing tremor. Also, finger tapping tests have been used to identify FT, showing positive potential as supplementary evidence.

Imaging studies in general are mostly underpowered and imaging cannot be used on an individual basis. Therapeutic studies in FT often have a diagnostic component. Cognitive behavioral therapy should be the preferred psychological treatment independent of additional psychiatric symptoms. Other psychotherapeutic methods show lack of evidence concerning FT. Relaxation techniques and physiotherapy are an important additional feature, especially in children and adolescents. In regard to drug therapy, randomized and blinded trials are not available. A significant decrease in rating scales could be detected after active, not sham repetitive transcranial magnetic stimulation with a long-lasting effect. Also root magnetic stimulation seems to be effective. The clinical feature of tremor entrainment in FT can be used in combination with biofeedback as so-called tremor retrainment, using self-modulation of frequency and severity, to bring the movements under volitional control.

Conclusion

Diagnosis and treatment of FT is challenging and should include a combination of intensive clinical examination and targeted addition of standardized testing, especially electrophysiological methods. Often therapeutic effects have a diagnostic component. A multimodal strategy, considering psychological factors as a potential origin as well as maintaining effects seems to be most effective.
Hepatoprotective effect of Moringa oleifera extract on TNF-α and TGF-β expression in acetaminophen-induced liver fibrosis in rats
Authors: Aly Omnia , Abouelfadl Dalia M. , Shaker Olfat G. , Hegazy Gehan A. , Fayez Ahmed M. , Zaki Hanan Hassan
Published: December 2020

Background

It has been reported that Moringa oleifera (MO) has different medicinal properties. The aim of this study was to evaluate the hepatoprotective role of Moringa oleifera extract on acetaminophen-induced liver fibrosis in albino rats on a biochemical and histological basis. Forty male albino rats were divided into four groups: group I (control group), healthy rates; group II (acetaminophen group), rates received acetaminophen for induction of liver fibrosis; group III (treated group), liver fibrosis of rates treated with Moringa oleifera extract; and group IV (prophylactic group), rates treated with Moringa oleifera extract before and after induction of liver fibrosis. Serum liver function parameters were quantified using a spectrophotometer, while tumor necrosis factor α (TNF-α) and transformed growth factor beta (TGF- β) in liver tissue homogenate by means of enzyme-linked immunosorbent assay (ELISA), and expression of liver tissue TNF-α and TGF-genes was measured by real-time PCR after extraction and purification. Hepatic tissue was also evaluated under a microscope for histopathological changes.

Results

Our results showed a significant decrease in liver enzymes, TNF-α, and TGF-β in the treated and prophylactic groups compared to the acetaminophen group, and our biochemical data were consistent with the histopathological findings confirming the hepatoprotective effect of Moringa oleifera extract.

Conclusions

Biochemical parameters and histopathology results provide evidence that Moringa oleifera ethanolic extract has a great potential to prevent and improve liver damage due to its protective activity.
In silico analysis of non-synonymous single nucleotide polymorphisms of human DEFB1 gene
Authors: Venkata Subbiah Harini , Ramesh Babu Polani , Subbiah Usha
Published: November 2020

Background

Single nucleotide polymorphisms (SNPs) play a significant role in differences in individual’s susceptibility to diseases, and it is imperative to differentiate potentially harmful SNPs from neutral ones. Defensins are small cationic antimicrobial peptides that serve as antimicrobial and immunomodulatory molecules, and SNPs in β-defensin 1 (DEFB1 gene) have been associated with several diseases. In this study, we have determined deleterious SNPs of the DEFB1 gene that can affect the susceptibility to diseases by using different computational methods. Non-synonymous SNPs (nsSNPs) of the DEFB1 gene that have the ability to affect protein structure and functions were determined by several in silico tools—SIFT, PolyPhen v2, PROVEAN, SNAP, PhD-SNP, and SNPs&GO. Then, nsSNPs identified to be potentially deleterious were further analyzed by I-Mutant and ConSurf. Post-translational modifications mediated by nsSNPs were predicted by ModPred, and gene-gene interaction was studied by GeneMANIA. Finally, nsSNPs were submitted to Project HOPE analysis.

Results

Ten nsSNPs of the DEFB1 gene were found to be potentially deleterious: rs1800968, rs55874920, rs56270143, rs140503947, rs145468425, rs146603349, rs199581284, rs201260899, rs371897938, rs376876621. I-Mutant server showed that nsSNPs rs140503947 and rs146603349 decreased stability of the protein, and ConSurf analysis revealed that SNPs were located in conserved regions. The physiochemical properties of the polymorphic amino acid residues and their effect on structure were determined by Project HOPE.

Conclusion

This study has determined high-risk deleterious nsSNPs of β-defensin 1 and could increase the knowledge of nsSNPs towards the impact of mutations on structure and functions mediated by β-defensin 1 protein.
New Horizons: Does Mineralocorticoid Receptor Activation by Cortisol Cause ATP Release and COVID-19 Complications?
Authors: Edwards Christopher
Published: November 2020

This paper attempts to explain how the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus causes the complications that make coronavirus disease 2019 (COVID-19) a serious disease in specific patient subgroups. It suggests that cortisol-associated activation of the mineralocorticoid receptor (MR) in epithelial and endothelial cells infected with the virus stimulates the release of adenosine 5′-triphosphate (ATP), which then acts back on purinergic receptors. In the lung this could produce the nonproductive cough via purinergic P2X3 receptors on vagal afferent nerves. In endothelial cells it could stimulate exocytosis of Weibel-Palade bodies (WPBs) that contain angiopoietin-2, which is important in the pathogenesis of acute respiratory distress syndrome (ARDS) by increasing capillary permeability and von Willebrand factor (VWF), which mediates platelet adhesion to the endothelium and hence clotting. Angiopoietin-2 and VWF levels both are markedly elevated in COVID-19–associated ARDS. This paper offers an explanation for the sex differences in SARS-CoV-2 complications and also for why these are strongly associated with age, race, diabetes, and body mass index. It also explains why individuals with blood group A have a higher risk of severe infection than those with blood group O. Dexamethasone has been shown to be of benefit in coronavirus ARDS patients and has been thought to act as an anti-inflammatory drug. This paper suggests that a major part of its effect may be due to suppression of cortisol secretion. There is an urgent need to trial the combination of dexamethasone and an MR antagonist such as spironolactone to more effectively block the MR and hence the exocytosis of WPBs.
Do the Heterozygous Carriers of a CYP24A1 Mutation Display a Different Biochemical Phenotype Than Wild Types?
Authors: Brancatella Alessandro , Cappellani Daniele , Kaufmann Martin , Borsari Simona , Piaggi Paolo , Baldinotti Fulvia , Caligo Maria Adelaide , Jones Glenville , Marcocci Claudio , Cetani Filomena
Published: November 2020

Context

Human cytochrome P450 24 subfamily A member 1 (CYP24A1) loss-of-function mutations result in impaired activity of the 24-hydroxylase involved in vitamin D catabolism, thus inducing a vitamin D-dependent hypercalcemia. Homozygotes often present an overt clinical phenotype named idiopathic infantile hypercalcemia (IIH), whereas it is debated whether heterozygotes display an abnormal phenotype.

Objective

To compare the clinical and biochemical features of heterozygous carriers of CYP24A1 variant and healthy wild-type controls sharing the same genetic and environmental exposure.

Methods

A large family harboring the nonsense c.667A>T, p.Arg223* pathogenic variant in the CYP24A1 gene was evaluated. All subjects underwent clinical and biochemical evaluation and complete analysis of vitamin D metabolites using mass spectroscopy including 1,24,25(OH)3D3. Subjects were divided into 2 groups according to their genotype: heterozygotes and wild-type for the CYP24A1 variant.

Results

The proband, a 40-year-old man, homozygous for p.Arg223* pathogenic variant, had a history of mild hypercalcemia with a seasonal trend, recurrent nephrolithiasis, and no episodes of acute hypercalcemia. He showed the highest serum levels of fibroblast growth factor 23, the highest 25(OH)D3/24,25(OH)2D3 ratio and undetectable levels of 1,24,25(OH)3D3, which represent indicators of a loss-of-function CYP24A1. Compared with the wild-types, heterozygotes had higher serum calcium and 25(OH)D3 concentrations (P = .017 and P = .025, respectively), without any difference in the other biochemical parameters and in the rate of nephrolithiasis.

Conclusion

Heterozygotes exhibit a biochemical phenotype different from that of wild-type subjects. In clinical practice, these individuals might require surveillance because of the potential risk of developing hypercalcemia and related clinical manifestations if exposed to triggering factors.
Insulin Resistance Is Central to Long-Term Reversal of Histologic Nonalcoholic Steatohepatitis After Metabolic Surgery
Authors: Russo Maria Francesca , Lembo Erminia , Mari Andrea , Angelini Giulia , Verrastro Ornella , Nanni Giuseppe , Pompili Maurizio , Raffaelli Marco , Vecchio Fabio Maria , Bornstein Stefan R , Mingrone Geltrude
Published: November 2020

Context

Nonalcoholic steatohepatitis (NASH) is considered the hepatic counterpart of metabolic syndrome.

Objective

This work aimed to investigate the determinants of NASH reversal in patients undergoing biliopancreatic diversion (BPD) in a 5-year follow-up study.

Methods

This prospective study was conducted at Policlinico Universitario Agostino Gemelli. A total of 37 patients underwent fine-needle liver biopsy during BPD. Ultrasonography-guided percutaneous liver biopsy was obtained 5 years after the operation. The primary outcome of our study was histologic NASH reversal at 5-year follow-up. To better characterize the clinical variables involved in the resolution of NASH, we also compared patients without histologic NASH resolution at 5 years with those in whom NASH had disappeared.

Results

At follow-up, NASH had reversed in 56.5% of the patients. The NAFLD activity score (NAS) improved from 3.7 ± 0.93 to 2 ± 1.11 (P < .001). Fibrosis reversed in 16% patients (P = .022), and 32% improved (95% CI, 0.05-0.54). No significant differences in body mass index or clinical parameters changes explained the effect of surgery on NASH, apart from the measure of insulin sensitivity post surgery. The Homeostasis Model Assessment of Insulin Resistance decreased from 3.31 ± 1.72 at baseline to 1.73 ± 1.08 (P < .001) after BPD, and the Matsuda index improved from 2.66 ± 1.79 to 4.73 ± 3.05 (P < .001). The lipid profile normalized (total cholesterol from 4.75 ± 1.18 to 3.32 ± 0.77 mmol/L, P < .001; low-density lipoprotein cholesterol from 2.92 ± 0.91 to 1.60 ± 0.51 mmol/L, P = .0001; high-density lipoprotein cholesterol from 0.97 ± 0.33 to 1.10 ± 0.35 mmol/L, P = .023; triglycerides from 2.52 ± 1.6 to 1.47 ± 0.67 mmol/L, P = .003). Neural network analysis showed that the end-study Matsuda index discriminated between responders and nonresponders with high accuracy (receiver operating characteristic area under the curve = 0.98%).

Conclusion

Remission of NASH is driven by reversal of whole-body insulin resistance post intervention.
A Case of Luscan-Lumish Syndrome: Possible Involvement of Enhanced GH Signaling
Authors: Suda Kentaro , Fukuoka Hidenori , Iguchi Genzo , Kanie Keitaro , Fujita Yasunori , Odake Yukiko , Matsumoto Ryusaku , Bando Hironori , Ito Hiroki , Takahashi Michiko , Chihara Kazuo , Nagai Hiroshi , Narumi Satoshi , Hasegawa Tomonobu , Ogawa Wataru , Takahashi Yutaka
Published: November 2020

Context

Luscan-Lumish syndrome (LLS) is characterized by postnatal overgrowth, obesity, Chiari I malformation, seizures, and intellectual disability. SET domain-containing protein 2 (SETD2) is a histone methyltransferase, where mutations in the gene are associated with the development of LLS. However, mechanisms underlying LLS remain unclear.

Case Description

A 20-year-old man was referred to our hospital because of tall stature. His body height was 188.2 cm (+3.18 SD) and he showed obesity with a body mass index of 28.4 kg/m2. He exhibited acral overgrowth, jaw malocclusion, and prognathism, but no history of seizures, intellectual disability, or speech delay. Serum growth hormone (GH), insulin-like growth factor 1 (IGF-1), and nadir GH levels after administration of 75 g oral glucose were within normal range. Pituitary magnetic resonance imaging showed no pituitary adenoma, but Chiari I malformation. Whole exome sequencing analysis of the proband revealed a de novo heterozygous germline mutation in SETD2 (c.236T>A, p.L79H). Skin fibroblasts derived from the patient grew faster than those from his father and the control subject. In addition, these cells showed enhanced tyrosine phosphorylation and transcriptional activity of signal transducer and activator of transcription 5b (STAT5b) and increased IGF-1 expression induced by GH.

Conclusion

This is a mild case of LLS with a novel mutation in SETD2 without neurological symptoms. LLS should be differentiated in a patient with gigantism without pituitary tumors. Although further investigation is necessary, this is the first study to suggest the involvement of aberrant GH signaling in the development of LLS.
Microvascular Benefits of New Antidiabetic Agents: A Systematic Review and Network Meta-Analysis of Kidney Outcomes
Authors: Cha Ashley S , Chen Yilin , Fazioli Katherine , Rivara Matthew B , Devine Emily Beth
Published: November 2020

Context

Diabetic kidney disease affects nearly one-third of US adults with prevalent type 2 diabetes mellitus (T2DM). The use of new antidiabetic medications in the prevention and treatment of diabetic kidney disease is a growing area of research interest.

Objective

We sought to characterize the risk of developing a composite kidney outcome among patients receiving a new antidiabetic medication of the SGLT-2i, GLP-1ra, and DPP-4i drug classes.

Methods

We conducted a systematic literature search in MEDLINE to identify randomized trials observing kidney safety endpoints associated with the use of new antidiabetic medications. Two independent reviewers selected the 7 eligible studies for analysis. Included studies were published between January 2013 and March 2020, conducted with adult participantss, published full-text in English, and observed composite kidney outcomes. A network meta-analysis was conducted within a Bayesian framework using a fixed-effects model with uninformative priors.

Results

A qualitative assessment of transitivity was conducted to ensure similar distribution of potential modifiers across studies. Included studies were generally comparable in mean age, glycated hemoglobin A1c (HbA1c), and mean duration of T2DM at baseline.

Main Conclusions

Compared with placebo, dapagliflozin was associated with the greatest reduction in risk of developing the composite kidney outcome (hazard ratio 0.53; 95% credible interval, 0.43-0.66) followed by empagliflozin, canagliflozin, semaglutide, and liraglutide. Linagliptin did not show a significant reduction in risk of the outcome.

Limitations

This analysis was limited by the scarcity of data for kidney safety endpoints in large, randomized clinical trials. Although the heterogeneity statistic was low, there are slight differences in study design and baseline demographic characteristics across trials.
Vitamin D-regulated Gene Expression Profiles: Species-specificity and Cell-specific Effects on Metabolism and Immunity
Authors: Dimitrov Vassil , Barbier Camille , Ismailova Aiten , Wang Yifei , Dmowski Katy , Salehi-Tabar Reyhaneh , Memari Babak , Groulx-Boivin Emilie , White John H
Published: November 2020

Vitamin D has pleiotropic physiological actions including immune system regulation, in addition to its classical role in calcium homeostasis. Hormonal 1,25-dihydroxyvitamin D (1,25D) signals through the nuclear vitamin D receptor, and large-scale expression profiling has provided numerous insights into its diverse physiological roles. To obtain a comprehensive picture of vitamin D signaling, we analyzed raw data from 94 (80 human, 14 mouse) expression profiles of genes regulated by 1,25D or its analogs. This identified several thousand distinct genes directly or indirectly up- or downregulated in a highly cell-specific manner in human cells using a 1.5-fold cut-off. There was significant overlap of biological processes regulated in human and mouse but minimal intersection between genes regulated in each species. Disease ontology clustering confirmed roles for 1,25D in immune homeostasis in several human cell types, and analysis of canonical pathways revealed novel and cell-specific roles of vitamin D in innate immunity. This included cell-specific regulation of several components of Nucleotide-binding Oligomerization Domain-like (NOD-like) pattern recognition receptor signaling, and metabolic events controlling innate immune responses. Notably, 1,25D selectively enhanced catabolism of branched-chain amino acids (BCAAs) in monocytic cells. BCAA levels regulate the major metabolic kinase mammalian Target of Rapamycin (mTOR), and pretreatment with 1,25D suppressed BCAA-dependent activation of mTOR signaling. Furthermore, ablation of BCAT1 expression in monocytic cells blocked 1,25D-induced increases in autophagy marker LAMP1. In conclusion, the data generated represents a powerful tool to further understand the diverse physiological roles of vitamin D signaling and provides multiple insights into mechanisms of innate immune regulation by 1,25D.
MicroRNA-7a2 Regulates Prolactin in Developing Lactotrophs and Prolactinoma Cells
Authors: LaPierre Mary P , Godbersen Svenja , Torres Esteban Mònica , Schad Anaïs Nura , Treier Mathias , Ghoshdastider Umesh , Stoffel Markus
Published: November 2020

Prolactin production is controlled by a complex and temporally dynamic network of factors. Despite this tightly coordinated system, pathological hyperprolactinemia is a common endocrine disorder that is often not understood, thereby highlighting the need to expand our molecular understanding of lactotroph cell regulation. MicroRNA-7 (miR-7) is the most highly expressed miRNA family in the pituitary gland and the loss of the miR-7 family member, miR-7a2, is sufficient to reduce prolactin gene expression in mice. Here, we used conditional loss-of-function and gain-of-function mouse models to characterize the function of miR-7a2 in lactotroph cells. We found that pituitary miR-7a2 expression undergoes developmental and sex hormone–dependent regulation. Unexpectedly, the loss of mir-7a2 induces a premature increase in prolactin expression and lactotroph abundance during embryonic development, followed by a gradual loss of prolactin into adulthood. On the other hand, lactotroph development is delayed in mice overexpressing miR-7a2. This regulation of lactotroph function by miR-7a2 involves complementary mechanisms in multiple cell populations. In mouse pituitary and rat prolactinoma cells, miR-7a2 represses its target Raf1, which promotes prolactin gene expression. These findings shed light on the complex regulation of prolactin production and may have implications for the physiological and pathological mechanisms underlying hyperprolactinemia.
Multiple Endocrine Neoplasia Type 1: Latest Insights
Authors: Brandi Maria Luisa , Agarwal Sunita K , Perrier Nancy D , Lines Kate E , Valk Gerlof D , Thakker Rajesh V
Published: November 2020

Multiple endocrine neoplasia type 1 (MEN1), a rare tumor syndrome that is inherited in an autosomal dominant pattern, is continuing to raise great interest for endocrinology, gastroenterology, surgery, radiology, genetics, and molecular biology specialists. There have been 2 major clinical practice guidance papers published in the past 2 decades, with the most recent published 8 years ago. Since then, several new insights on the basic biology and clinical features of MEN1 have appeared in the literature, and those data are discussed in this review. The genetic and molecular interactions of the MEN1-encoded protein menin with transcription factors and chromatin-modifying proteins in cell signaling pathways mediated by transforming growth factor β/bone morphogenetic protein, a few nuclear receptors, Wnt/β-catenin, and Hedgehog, and preclinical studies in mouse models have facilitated the understanding of the pathogenesis of MEN1-associated tumors and potential pharmacological interventions. The advancements in genetic diagnosis have offered a chance to recognize MEN1-related conditions in germline MEN1 mutation–negative patients. There is rapidly accumulating knowledge about clinical presentation in children, adolescents, and pregnancy that is translatable into the management of these very fragile patients. The discoveries about the genetic and molecular signatures of sporadic neuroendocrine tumors support the development of clinical trials with novel targeted therapies, along with advancements in diagnostic tools and surgical approaches. Finally, quality of life studies in patients affected by MEN1 and related conditions represent an effort necessary to develop a pharmacoeconomic interpretation of the problem. Because advances are being made both broadly and in focused areas, this timely review presents and discusses those studies collectively.
Standardizing a unique renewable energy supply chain: the SURESC Model
Authors: Finocchi Emiliano
Published: December 2020

This study intends to dig into the renewable energy industry and drawing from research on learning curves and energy polices, proposes a way to speed-up the energy shift from our fossil-fuel dependency to a green economy. Even though standard economic frameworks suggest that markets and not policy makers should decide winners and losers, we urge to accelerate renewable energy competitiveness, proposing that by limiting the number of renewable technologies where resources are allocated to at government level, we reduce the time within which renewables will achieve technological price parity with fossil fuels. In turn, by analyzing the energy demand and supply curves, the study suggests that this action will also mediate the relation between quantity and price, shifting only the supply curve, leaving the demand curve unaffected. It continues by proposing the standardization of a unique renewable energy supply chain model, later defined as the SURESC model.  For such, a deep analysis on existing green technologies will be performed proposing the implementation of a hydrogen through ammonia economy via ammonia for power as key factor for success. This is a preliminary study, first of its kind, intended to provide a holistic approach to a known problem.
Liquid crystal filter based tunable transmitter for 25Gps wavelength division multiplexing-passive optical network fronthaul
Authors: Park M. Y. , Kim B. W. , Moehrle M. , Troppenz U. , Rehbein W. , Sigmund A. , Hong S. J.
Published: November 2020

A novel tunable transmitter structure based on liquid crystal filter, to the best of our knowledge, is presented. The structure is designed for application to 5G fronthaul and supports 25 Gbps dense wavelength division multiplexing (WDM) transmission and tunable range of 35 nm. The design takes into account easy change of operation band over coarse WDM grid. Prototype samples are developed to test feasibility of the design.
Danke für die Blumen. Kontinuierliches Feedback als Qualitätssicherung im Schreibcoaching
Authors: Hollosi-Boiger Christina
Published: December 2020

Schreibcoaching ist eine personenzentrierte, längerfristige Entwicklungs- und Prozessbegleitung mit dem Fokus auf Schreibprozess, schreibender Person und/oder die entstehenden Texte. Aus Sicht des*der Coaches*in ist Schreibcoaching kein einmaliger Vorgang, sondern eine stetige Folge individueller Coachingprozesse. Auf diese sich wiederholenden Prozesse können Ansätze des Qualitätsmanagements übertragen werden, was in der Qualitätsdiskussion im Coaching allgemein bereits geschieht. Das vorgestellte Modell des Qualitätsmanagementsystems für das Schreibcoaching zeigt auf, dass Qualitätsmonitoring in allen Phasen erfolgen und sich konstitutiv auf das Coaching bzw. den Coachingerfolg auswirken kann. Grundlage hierfür bildet ein von dem*der Schreibcoach*in gesteuertes Qualitätskonzept, das Werte, Grundhaltungen und einen operationalisierten Qualitätsbegriff beinhaltet, und in Form eines Leitbilds veröffentlicht werden sollte. Das Fallbeispiel belegt die Umsetzbarkeit des Modells: Qualitätsmessungen aus 22 Schreibcoachings aus dem Bezugsrahmen des beruflichen Schreibens wurden mit der FeedbacktechnikDanke für die Blumendurchgeführt. Diese basiert auf der Blitzlicht-Technik und wurde flächendeckend und kontinuierlich in den Schreibcoachings der Autorin eingesetzt. Die Ergebnisse wurden mittels der inhaltlich strukturierenden, qualitativen Inhaltsanalyse nach Kuckartz rekurrierend auf die Qualitätskriterien im BC-Modell und einer deskriptiv-explorativen statistischen Analyse ausgewertet. Die Ergebnisse zeigen, dass abhängig von den Coachingzielen unterschiedliche Wahrnehmungen zum Schreibcoaching und zur Schreibcoach dominieren, diese sich dennoch über alle Qualitätsdimensionen des Schreibcoachings verteilen. Ein Abgleich mit dem Qualitätskonzept ist daher möglich und kann in einem wiederkehrenden Reflexionsprozess als Entscheidungsgrundlage für das Herbeiführen von Veränderungen herangezogen werden.
Incidence of Acute Myeloid Leukemia and Myelodysplastic Syndrome in Patients With Inflammatory Bowel Disease and the Impact of Thiopurines on Their Risk
Authors: Khan Nabeel , Patel Dhruvan , Trivedi Chinmay , Kavani Himanshu , Pernes Tyler , Medvedeva Elina , Lewis James , Xie Dawei , Yang Yu-Xiao
Published: November 2020

INTRODUCTION:

Acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) are rare myeloid clonal disorders that commonly affect the elderly population and have poor prognosis. There are limited data on the risk of AML/MDS among patients with inflammatory bowel disease (IBD), especially on the impact of thiopurines (TPs).

METHODS:

We conducted a retrospective cohort study among patients with IBD from Veteran Affairs data set. The exposure of interest was TP exposure: (i) never exposed to TPs, (ii) past TP use (discontinued >6 months ago), (iii) current TP use with a cumulative exposure of <2 years, and (iv) current TP use with a cumulative exposure of ≥2 years. The outcome of interest was a composite outcome of incident diagnosis of AML and/or MDS. Cox regression was used to estimate the adjusted and unadjusted hazard ratios (HRs) with 95% confidence intervals (CIs) for AML/MDS risk associated with TP use defined as a time-varying exposure.

RESULTS:

Among 56,314 study patients, 107 developed AML/MDS. The overall incidence of AML/MDS in the IBD population was 18.7 per 100,000 patient-years. The incidences among those never exposed to TPs, past users of TPs, current users of TPs with a cumulative exposure of <2 years, and current users of TPs with a cumulative exposure of ≥2 years were 17.0, 17.7, 30.4, and 30.3 per 100,000 patient-years, respectively. In multivariable Cox regression analysis, compared with never exposed to TPs, current use of TPs was associated with increased risk (adjusted HR 3.05; 95% CI 1.54–6.06, P = 0.0014 for current use of TPs with a cumulative exposure of <2 years and adjusted HR 2.32; 95% CI 1.22–4.41, P = 0.0101 for current use of TPs with a cumulative exposure of ≥2 years), whereas past TP exposure was not.

DISCUSSION:

Among patients with IBD, current TP use was associated with an increased risk of AML/MDS, which reverts to baseline after discontinuation of TP use.
Direct Ink Writing Method for Manufacturing Electronic Circuits Using Multiwalled Carbon Nanotubes and Polyvinyl Alcohol Composites
Authors: Ahammed Syed Riyaz , Praveen Ayyappan Susila
Published: December 2020

Usage of conductive materials for manufacturing electronic circuits using 3D printing methods plays a prominent role in sensing applications and has achieved significant growth in recent years. This growth has led to the development of stretchable, flexible electronics and wearable electronics that are useful as sensing applications in the fields of real-time health monitoring systems. In this paper, a multiwalled carbon nanotube (MWCNT)-based electronic circuit was developed using the 3D printing technique called direct ink writing (DIW). Polyvinyl alcohol (PVA) was used as the binder material to make the MWCNT ink for printing. Different concentrations of MWCNT ink were prepared using 5, 10, and 15 wt. % PVA solutions. The viscosity of MWCNT inks was measured using a rheometer (cone and plate type). The ink exhibited shear thinning behavior, which is suitable for DIW. Finally, the printing of a designed electronic circuit was carried out using a pneumatic extrusion–based 3D printer. The strain sensor circuit—measuring 20 mm long, 9.2 mm wide, and 0.8 mm thick—is manufactured by the 3D printer. Electrical resistivity of strain sensor circuit is evaluated by adopting a two-probe method; the observed resistivity value was 1.7 × 10−2 Ωm for MWCNT ink made with 10 wt. % PVA solution and 1.97 × 10−2 Ωm for MWCNT ink made with 15 wt. % PVA solution.
KNOWLEDGE MANAGEMENT, ORGANIZATIONAL AMBIDEXTERITY, AND MANUFACTURING PERFORMANCE IN THE ERA OF INDUSTRY 4.0: A PROPOSED MODEL
Authors: Seng Cheong Cheah , Tan Cheng Ling
Published: November 2020

Fourth Industrial Revolution (IR4.0) is changing the landscape of global manufacturing. As a developing nation, Malaysia’s manufacturing sector is a leading contributor to the nation’s GDP but its growth is in declining mode recently. Facing competition from countries with lower labour cost, Malaysia needs alternative ways to achieve competitive advantage. Many of its manufacturers are new to IR4.0 and also cautious of investing in such technologies to increase its manufacturing performance. Realizing this, Malaysia’s government introduced a policy on IR4.0 by focusing on the people, process and technology. The goal is to increase the skill set of the existing workforce through knowledge enhancement and adoption of advance manufacturing technologies. However, high level of transformation is needed, collaboration with external parties is important, and internal business processes and operating models need to change too. Many of them are lack in slack resources to pursue both explorative and exploitative learning. Organizational ambidexterity, which is the ability of a firm to manage both of these activities is crucial for proper knowledge management and improving manufacturing performance. The objective of this paper is to examine such interconnection from the context of a developing country as information from extant literature is scarce, especially on the balanced approach to source, transfer and protect the knowledge for optimum gain in manufacturing performance. Three main activities of knowledge management will be examined namely external knowledge sourcing, knowledge mobility and knowledge protection. The inclusive of knowledge protection also narrow the literature gap as it tends to be left out in previous studies due to its conflicting nature with other knowledge management activities. All the hypotheses and resulted conceptual model will be grounded with theories of Resource-Based view (RBV), Knowledge-Based View (KBV), Dynamic Capabilities and OA.
VALUE CREATION NETWORKING DIMENSION DOMINATION ON ENTREPRENEURIAL MARKETING BEHAVIOR: A PERSPECTIVE OVERVIEW OF COMPANIES MANAGED BY FOUNDERS AND PROFESSIONALS
Authors: Susanto Hendro , Utami Christina Whidya
Published: November 2020

The aim of this study is to fill the gap in the study of Entrepreneurial Marketing behaviour. Previous studies are found to be insufficient in determining the most dominant dimension that contributes to the differences in entrepreneurial marketing behaviour when implemented in companies with certain characteristics. Entrepreneurial marketing dimension in this study focuses on Growth Orientation, Opportunity Orientation, Total customer focus, Value creation Networking, Informal Market Analysis, Closeness to The Market, and whether those factors result in differences in the behaviour of founders and professionals in managing companies. The study was conducted on 406 business owners in 8 provinces in Indonesia. Snowball sampling was used to select the respondents from the overall company population in Indonesia, be it services or manufacturing company. The result of the study indicates that lower Entrepreneurial Marketing behaviour is found in companies managed by founders compared to companies managed by professionals. This study also contributes to findings on Value Creation Networking dimension that is proven to be the most dominant dimension in influencing Entrepreneurial Marketing behaviour, be it for founders or professionals in managing companies.
FACTORS INFLUENCING ELECTRONIC WASTE (E-WASTE) SEPARATION INTENTION OF ELECTRONIC SHOP OWNERS IN BANGLADESH: A CONCEPTUAL MODEL
Authors: Rahman Ashikur , Teoh Ai Ping , Mahmud Imran
Published: November 2020

Bangladesh observes the production of approximately 400,000 metric tonnes of e-waste every year. It is expected that it will witness a 20% increase annually. In order to implement e-waste recycling, it is essential to uncover the influencing factors. In this study, electronic shop owners act as one of the major players responsible for the aggregation of e-waste in the country. Based on Value-Belief-Norm Theory, Self Determination Theory and synthesizing relevant literature in the body of knowledge, this paper presents an integrated conceptual model consisting Altruistic values, Egoistic values, Biosphric values, Environmental belief, Personal norm, Intrinsic motivation and Extrinsic motivation, which are predicted to influence e-waste separation intention in Bangladesh. From a practical point of view, this research sheds light on key determinants that affect separation intention, in which practitioners need to consider when developing strategies concerning e-waste management and policies in Bangladesh.
ENVIRONMENTAL PROACTIVITY ON ENVIRONMENTAL PERFORMANCE: AN EXTENSION OF NATURAL RESOURCE-BASED VIEW THEORY (NRBV)
Authors: Appannan Jeya Santhini , Mohd Said Ridzwana , Tze San Ong , Senik Rosmila
Published: November 2020

Extensive use of global resources and the associated environmental impacts continue to grow. As a result, green operations have received continuous attention from the business sector in recent years. However, only a few studies unpacked its dimension and examined environmental management accounting (EMA) and the firm's performance. The purpose of this paper is to (i) review the connection of holistic accounting approach of EMA and environmental performance in the extant literature and (ii) deepen the theory of NRBV by incorporating environmental proactivity as a moderator in the framework to provide an additional theoretical explanation to environmental performance in the context of ISO 14001 companies in Malaysia. Using the data of 145 companies, this study revealed that environmental proactivity moderates the relationship between EMA and environmental performance. Interestingly, we also found that EMA showed positive relationship on environmental performance. The research findings will be particularly important for ISO 14001 companies in developing their strategies and policies to achieve sustainable performance. Furthermore, the outcome will give some remarkable insights for managers to identify the current standing of their firm’s environmental performance.
A REVIEW ON TECHNOLOGY READINESS CONCEPT TO EXPLAIN CONSUMER’S ONLINE PURCHASE INTENTION
Authors: Ismail Khairull Anuar , Abdul Wahid Nabsiah
Published: November 2020

Recently in Malaysia, a substantial number of consumers have been found to be avoiding online shopping as they prefer to shop in physical stores. This scenario brings up the issue of whether Malaysian consumers are ready technologically to shop online. To tackle this issue, a review of the concept of technology readiness is made to help explain Malaysian consumers’ online purchase intention behaviour. Technology readiness is chosen here because the concept reflects an individual’s predisposition in the usage and adoption of new technology. For the purpose of this review, this study selects technology readiness concept as proposed by Parasuraman  (2000). From the review, this study found that technology readiness has been measured in the past either as a single (unidimensional) or a multidimensional construct involving four factors, namely, optimism, innovativeness, discomfort and insecurity. A summary on past researchers’ findings in identifying the relationship between technology readiness (and its proposed dimensions) with technology usage is included in this review. For example, technology readiness was found to have a significant influence on behavioural intention in using mobile commerce to purchase travel-related service. Additionally, technology readiness motivator (optimism and innovativeness) and inhibitor (discomfort and insecurity) were identified to be related to intention to use technology. Based on the review, this study proposes a model to help explain the user’s intention to purchase online situation. In the proposed model, both technology readiness motivators and inhibitors are suggested to show positive and negative influences respectively on the user’s intention to purchase online. This review is thought to be beneficial to many. For instance, researchers would find insights on the usefulness of technology readiness and on how it has been and can be applied for further investigation. As for marketing practitioners, the review would help guide them understand the influence technology readiness has on consumers behaviour intention in adopting online shopping which they could apply for future marketing strategy.
CONCEPTUAL FRAMEWORK OF GREEN-BUILDING ADOPTION AMONG CONSTRUCTION COMPANIES IN SAUDI ARABIA: THE EFFECT OF PROACTIVE ENTREPRENEURIAL BEHAVIOR, GREEN PRODUCT INNOVATION, AND GOVERNMENT SUPPORT
Authors: Alkahtani Asem , Nordin Norfarah
Published: November 2020

Saudi Arabia is facing the rising of the global population and high resource use. The country needs to inculcate the adoption of sustainable practices, i.e. green building practices. However, adopting green building practices for a sustainable future requires fundamental changes in the way contractors build houses. This paper endeavours to conceptualize the elements that contribute to the adoption of green building among the contraction companies in Riyadh. Literature reviews and government document reviews are used for the conceptualization of the framework. Based on the resource-based view theory, the factors are conceptualized with small and medium-sized enterprise contractors as the subject of focus. This paper proposes that green builders or the construction companies’ internal resources, i.e. proactive entrepreneurial behaviour, are hypothesized to influence green building adoption. However, risk-taking and green product innovation are proposed to mediate the relationships. These factors are moderated by Saudi Arabian government support, financial and non-financial. By addressing these factors regarding green building practices, Saudi Arabia would be able to achieve sustainable development in the housing of its citizens.
Determining of unknown functions of different arguments in minor coefficient and right-hand side of semilinear ultraparabolic equation
Authors: Protsakh N.P. , Flyud V.M.
Published: November 2020

In this paper, we consider the inverse problem for semilinear ultraparabolic equation. The equation has two unknown functions of different arguments in its minor coefficient and in right-hand side function. The sufficient conditions of the existence and the uniqueness of solution on some interval $[0,T],$ where $T$ depends on the coefficients of the equation, are obtained.
Pre-prosthetic Orthodontic Implant for an Aesthetic Rehabilitation : A Case Report
Authors: Houb-dine Afaf , Regragui Anissa , Benkaddour Asmaa , Bahoum Asmaa , Zaoui Fatima
Published: November 2020

A combination of dental problems such as missing teeth, proclination of teeth and occlusal problems cannot be satisfactorily treated by prosthodontic approach alone. The rehabilitation of patients requiring an esthetic smile demands the collaboration of multiple dental specialists. the need for orthodontic tooth movement prior to restorative treatment is necessary for some patients, in order to optimize both esthetic and functional aspects of dental treatment.The present case report achieved successful implant based oral rehabilitation in a patient with  absence of the right maxillary central incisor utilizing a preprosthetic orthodontic implant site preparation for the purpose of space gain.
Optogenetics: The Key to Deciphering and Curing Neurological Diseases
Authors: Wang Fuzhou
Published: December 2020

Optogenetics is an emerging branch of biology that combines genetics and optics to achieve precise light control of specific cells in organisms. It is a method of studying excitable cells that uses proteins that are embedded in the cell membrane and are activated by light (i.e. “opto”). Such proteins (opsins) are found in most animals in the retina of the eyes, as well as in some plants, such as green algae. In order to integrate photoactivated proteins into neuronal membranes, it is necessary to introduce rhodopsin genes obtained from other organisms into neurons, hence the “genetics”. Optogenetics is widely used in the field of modern neurobiology, and plays an essential role in the study of the mechanism of neural circuits, behaviors, central nervous system diseases, and mental disorders. Based on the development of optogenetics technology, this paper introduces its optimization and localization expression, which not only provides references for the research and development of optogenetics, but also provides the possibility for in-depth research and treatment of neurological diseases.
The Origin of Paleozoic Terranes in Northeastern Asia: Geologic Evidence for Rifting of the Pericratonic Margin of the Siberian Paleocontinent and for Migration of Its Fragments
Authors: Kanygin A.V. , Gonta T.V. , Timokhin A.V.
Published: November 2020

––The paper provides an insight into the geodynamic history of the Northeast Asian terranes during the Paleozoic, focused on the stratigraphic, paleontological, and sedimentological data indicating that the Precambrian structures of early–middle Paleozoic age were originally part of the passive margin of the Siberian paleocontinent. The geological and paleontological data presented in the foregoing studies have shown the inherited geodynamic regime and synchronous sedimentation and magmatism on the passive continental margin and in most terranes before their separation from the Siberian paleocontinent in the late Paleozoic. The revealed significant differences in evolution between the Okhotsk and Omolon and other terranes give grounds to postulate that they rifted off the paleocontinent even earlier.