bluuebunny/crossref_metadata_2025 huggingface dataset:
Exosomal-mediated transfer of OIP5-AS1 enhanced cell chemoresistance to trastuzumab in breast cancer via up-regulating HMGB3 by sponging miR-381-3p
Authors: Yu Qiang , Li Yinmou , Peng Shijun , Li Jing , Qin Xianxiong
Published: March 2021

Background

Long noncoding RNA OPA-interacting protein 5 antisense transcript 1 (OIP5-AS1) was confirmed to involve in the malignancy of breast cancer. However, whether exosomal OIP5-AS1 is implicated in trastuzumab resistance remains unclear.

Methods

The IC50 value of cells to trastuzumab, cell proliferation, migration, and apoptosis was analyzed by cell counting kit-8 assay, colony formation assay, transwell assay, or flow cytometry, respectively. The expression of OIP5-AS1 and microRNA (miR)-381-3p was detected using quantitative real-time polymerase chain reaction. Exosomes were isolated by ultracentrifugation and qualified by nanoparticle tracking analysis software. Western blot was used to detect the protein levels of tumor susceptibility gene 101 (TSG101), CD81, CD63, or high-mobility group protein B3 (HMGB3). The interaction between miR-381-3p and OIP5-AS1 or HMGB3 was confirmed by dual-luciferase reporter assay and pull-down assay. In vivo experiments were conducted using murine xenograft models.

Results

OIP5-AS1 was elevated in trastuzumab-resistant breast cancer cells, and OIP5-AS1 knockdown rescued trastuzumab sensitivity. Extracellular OIP5-AS1 was packaged into exosomes, which were secreted by trastuzumab-resistant cells, and could be absorbed by trastuzumab-sensitive cells in breast cancer. Importantly, intercellular transfer of OIP5-AS1 via exosomes enhanced trastuzumab resistance in vitro. OIP5-AS1 was a sponge of miR-381-3p; besides, miR-381-3p targeted HMGB3. Murine xenograft analysis showed exosomal OIP5-AS1 induced trastuzumab resistance in vivo. Exosomal OIP5-AS1 was dysregulated in the serum of breast cancer patients and might be a promising diagnostic biomarker in trastuzumab resistance.

Conclusion

Intercellular transfer of OIP5-AS1 by exosomes enhanced trastuzumab resistance in breast cancer via miR-381-3p/HMGB3 axis, indicating a potential therapeutic strategy to boost the effectiveness of trastuzumab in resistant breast cancer patients.
Disparity in clinical characteristics between 2019 novel coronavirus pneumonia and leptospirosis
Authors: Li BinBin , Bao ChunMiao
Published: March 2021

Objective

A cluster outbreak of patients with similar symptoms and computed tomographic (CT) images of COVID-19 were diagnosed with leptospirosis. This study was aimed to identify the clinical difference between leptospirosis and COVID-19, providing evidence for strategy optimization.

Methods

A cohort of leptospirosis patients were collected and compared with age- and gender-matched COVID-19 cases in the epidemiological investigation, chest CT scan, laboratory tests, and length of hospital stay.

Results

Compared with COVID-19, contacting floodwater and lack of family clustering were features of leptospirosis in epidemiological assessment. In the laboratory test, higher level of white blood cells (WBCs: (10.38 ± 4.56) × 109/L vs (6.45 ± 1.95) × 109/L, p < 0.001), C-reactive protein (CRP: (138.93 ± 73.03) mg/L vs (40.28 ± 30.38) mg/L, p < 0.001), Creatine ((88.27 ± 35.16) mmol/L vs (63.31 ± 14.50) mmol/L, p < 0.001), and a lower level of platelet ((152.93 ± 51.93) × 109/L vs (229.65 ± 66.59) × 109/L, p < 0.001) were detected on patients with leptospirosis.

Conclusion

Given the epidemiological differences and seasonal prevalence, it is important to suspect leptospirosis in cases with a similar presentation of COVID-19. The clinical disparities may facilitate the therapeutic management of these two diseases.
Stakeholder and Data-Driven Fall Screen in a Program of All-Inclusive Care for the Elderly: Quality Improvement Initiative
Authors: Gustavson Allison M. , Falvey Jason R. , LeDoux Cherie V. , Stevens-Lapsley Jennifer E.
Published: March 2021

Background and Purpose:

The Program of All-Inclusive Care for the Elderly (PACE) delivers community-based long-term care services to low-income, nursing home eligible adults. In the PACE population, one of the most common reasons for hospitalizations is falls. The purpose of this quality improvement study was to create a stakeholder-driven process for developing a fall risk screen and evaluate how well this process discriminated injurious and noninjurious fallers.

Methods:

The quality improvement design was a prospective, longitudinal data collection for 5 PACE programs in Colorado. Physical therapists collected the Short Physical Performance Battery (SPPB) on participants at least annually. The Kotter practice change framework guided the processes for practice and organizational change in developing and implementing a fall screen.

Results and Discussion:

An iterative, stakeholder, and data-driven process allowed our team of researchers and a PACE program to establish a fall risk screen to stratify PACE participants. We provided feedback to PACE staff regarding screening rates and results on discrimination of faller status to promote continued uptake of screening and discussion regarding next steps. Rehabilitation therapists screened 66% of the PACE population, and participants were stratified into high risk (1-7 points) or low risk (8-12 points) based on the SPPB. Participants with low SPPB scores had 79% greater risk of a fall (risk ratio [RR] = 1.8; 95% confidence interval [CI], 1.5-2.1) and 86% greater risk of an injurious fall (RR = 1.9; 95% CI, 1.4-2.4), compared with those with high SPPB scores.

Conclusions:

Our study describes a collaboration to address fall rates in a PACE population. Program of All-Inclusive Care for the Elderly clinicians can use the identified cut-offs to stratify PACE populations at risk for falls and allocate scarce rehabilitation resources efficiently to best serve participants at highest risk, while using less resource-intensive interventions for those at lower risk.
«Продуктовый расизм» в ЕС: проблема сохраняется?
Authors: Roginko Sergey
Published: March 2021

Записка посвящена проблеме двойных стандартов качества товаров, производимых в ЕС транснациональными компаниями для стран Западной и Восточной Европы. Дается анализ серьезности этой проблемы на примерах проведенных в отдельных странах ЕС исследований разницы в качестве продаваемой в Восточной и Западной Европе продукции. Оценивается политический резонанс проблемы, характер и эффективность мер, предпринимаемых Еврокомиссией для ее решения. Делается прогноз развития ситуации с учетом факторов пандемии COVID-19, снижения мобильности и цифровизации торговли.
Analysis of Coronary Angiography Video Interpolation Methods to Reduce X-ray Exposure Frequency Based on Deep Learning
Authors: Yin Xiao-lei , Liang Dong-xue , Wang Lu , Qiu Jing , Yang Zhi-yun , Dong Jian-zeng , Ma Zhao-yuan
Published: March 2021

Cardiac coronary angiography is a major technique that assists physicians during interventional heart surgery. Under X-ray irradiation, the physician injects a contrast agent through a catheter and determines the coronary arteries’ state in real time. However, to obtain a more accurate state of the coronary arteries, physicians need to increase the frequency and intensity of X-ray exposure, which will inevitably increase the potential for harm to both the patient and the surgeon. In the work reported here, we use advanced deep learning algorithms to find a method of frame interpolation for coronary angiography videos that reduces the frequency of X-ray exposure by reducing the frame rate of the coronary angiography video, thereby reducing X-ray-induced damage to physicians. We established a new coronary angiography image group dataset containing 95,039 groups of images extracted from 31 videos. Each group includes three consecutive images, which are used to train the video interpolation network model. We apply six popular frame interpolation methods to this dataset to confirm that the video frame interpolation technology can reduce the video frame rate and reduce exposure of physicians to X-rays.
Le persuasif et le convaincant : pour une caractérisation fonctionnelle des interventions éducatives en sciences
Authors: Potvin Patrice , Bissonnette Marianne , Charland Patrick
Published: March 2021

Cet article propose une réflexion sur les problèmes et risques associés à certaines utilisations d’étiquettes permettant de qualifier les pratiques et les interventions pédagogiques testées, promues ou contestées dans le cadre de l’enseignement des sciences. Souvent pairées en dichotomies, ces étiquettes sont parfois présentées comme pouvant générer des problèmes de crédibilité des recherches qui les utilisent, ainsi que des incompréhensions et des blessures lorsqu’invoquées imprudemment en formation. Il propose ensuite une formule dichotomique et fonctionnelle permettant de caractériser les efforts éducatifs en prenant appui sur la différence ordinaire qui existe dans le langage courant entre la persuasion et la conviction.
Explicitation du savoir professionnel novice en Santé, assistance et soins infirmiers : un processus de raisonnement de métier
Authors: Daigle Ghyslaine , Alexandre Marie
Published: March 2021

L’élargissement du champ d’exercices défini par l’Ordre des infirmiers etinfirmières auxiliaires du Québec impose une hausse du niveau decompétences attendues, notamment en ce qui concerne le degréd’autonomie et le maintien de conditions d’exercice sécuritaires. Les écartsentre les savoirs de la formation et les savoirs requis par le marché dutravail semblent préoccupants. Cet article présente des résultats d’uneétude sur le savoir professionnel infirmier novice fondé sur le processus deraisonnement de métier. Les résultats d’un entretien d’explicitation conduitauprès d’une personne novice en première année de pratique suggèrentl’exercice d’un processus de résolution de problème soutenant l’agirprofessionnel infirmier
Improving Job Satisfaction and Organizational Commitment: Analysis of the Effects of the Principal Transformational Leadership
Authors: Novitasari Dewiana
Published: March 2021

This study aimed to measure the effect of dimensions of transformational leadership (i.e., idealized influence, inspirational motivation, intellectual stimulation and individualized consideration) on organizational commitment of the teachers of four private vocational school in Tangerang which are mediated by job satisfaction. Data collection was done by simple random sampling to 175 population of lecturers. The returned and valid questionnaire results were 131 samples. Data processing was used SEM method with Smart PLS 3.0 software. The results of this study concluded: first, the dimensions of transformational leadership: idealized influence, intellectual stimulation and individualized consideration have positive and significant effect on job satisfaction, except inspirational motivation. Second, the dimensions of transformational leadership: idealized influence, inspirational motivation, and individualized consideration have not significant effect on organizational commitment, except intellectual stimulation. Third, job satisfaction have a positive and significant effect on organizational commitment. Fourth, the dimensions of transformational leadership: idealized influence, intellectual stimulation and individualized consideration have positive and significant effect on organizational commitment through job satisfaction as mediation, but inspirational motivation have not significant effect on organizational commitment through job satisfaction as mediation. This research could pave the way to improve the lecturer readiness in facing the era of education 4.0.
Role of Social Media in Influencing The Visit of Domestic Tourist
Authors: Hartini Hartini , Fafurida Fafurida
Published: March 2021

The purpose of this study is to examine whether there is a relationship and the influence of the useof social media by tourists and how it plays a role in the visit of domestic tourists in Lawang SewuSemarang. The data used in this study are primary data with a sample of 73 respondents. Theresearch method uses descriptive statistical analysis, correlation coefficients and simple linearregression analysis with research variables including the level of social media use and domestictourist visits in and Lawang Sewu Semarang. The results showed that the level of social media useand domestic tourist visits in the two tourism objects were high with the percentage of 78% and82.79%. As for the role of social media there are 33% of tourists get information from social mediaand 93% of domestic tourists often upload the results of travel on social media. In addition, the useof social media also has a weak relationship and influences 8% of visits to Lawang Sewu.Suggestions that can be given from this research are for the management of Lawang Sewuattractions are expected to remain active in social media but to focus more on tourism promotionthrough other media.
Development Strategies for Tourism Destinations in Semarang Old Town
Authors: Ginanjar Retno , Prajanti Sucihatiningsih Dian Wisika
Published: March 2021

This study aims to analyze the priority strategies for developing tourism destinations in SemarangOld Town Area. This study was designed using a qualitative descriptive research method. The dataused in this study were primary and secondary data. The data collection techniques were throughinterviews, observation, documentation study, and AHP questionnaires. The data validitytechnique used in this study also used data triangulation technique, namely triangulation of sourcesand techniques. The analysis technique used in this study was to use Analysis Hierarchy Process(AHP) scheme to find an analysis of the criteria priority order from the strategies in developingtourism destinations in Semarang Old Town Area. The research results show that based on theresults of AHP analysis, the most prioritized criteria in the development strategy of tourismdestination in Semarang Old Town Area is tourism policies, followed by service criteria forvisitors in the second position, and tourism marketing criteria for the last priority. The last prioritycriterion is tourism marketing. Meanwhile, the result analysis on all alternatives shows that the firstpriority alternative is transportation control. The second priority alternative is providing a sense ofsecurity and comfort for visitors. Meanwhile, the last priority of all alternatives is the ease oflicensing to sell.
The Affirmation Special Allocation Fund and Regional Economic in Indonesia
Authors: Soraya Amanda Petty , Qibthiyyah Riatu Mariatul
Published: March 2021

Starting 2015, Government of Indonesia introduced Affirmation Special Allocation Fund (DAK). Affirmation DAK is expected to fund infrastructure, accessibility and improvement of basic services, as well as aiming to accelerate development in disadvantaged areas, border areas, outer islands, and transmigration areas. These targeted regions on average have low GRDP per capita. The purpose of this study is to determine the effect of Affirmation DAK on the regional economy in Indonesia. The existence of Affirmation DAK is expected to support equal distribution of basic infrastructure and services and accelerate development in Affirmation DAK receiving area which is a region with characteristics of disadvantaged areas, border areas, outermost islands and transmigration areas. This study uses panel data of 491 regencies/municipalities in 2011-2018  and using the fixed effect estimation method. Empirical results show that Affirmation DAK has not had a positive effect on GRDP per capita. Limiting estimation only to Affirmation DAK recipient regions, there is also no positive association between Affirmation DAK and GRDP per capita. The results of this study also show that the impact of Affirmation DAK is very small on the recipient area, implying that Affirmation DAK in its current form and existing pool fund size, has not yet an effective policy for regions exiting from “the lagging regions trap”. It is instead, still, revenue sharing and general allocation fund (DAU), that have consistent positive effect on regional economic growth, both are block grants that to an extent related to more discretionary to local governments in terms of use of fund.
Pembangkitan Massa Medan Skalar dan Boson Tera pada Model Simetri Kiri Kanan Termodifikasi Berdasarkan Grup Tera SU(3)_CâŠ—SU(2)_LâŠ—SU(2)_RâŠ—U(1)_Y
Authors: Istikomah Istikomah Istikomah
Published: March 2021

Modified Left-Right Symmetry Model has been constructed based on Â the gauge group . In this model there is a left sector consisting of Standard Model particles with the addition of right-handed neutrino Â and the doublet scalar , while the particle pairs are in the right sector. In addition, also added scalar fields Â and Â which can be intermediaries of interaction between the two sectors. Scalar fields masses can be generated via scalar potensial with the result that Â  . Whereas the mass of charged gauge bosons , the masses of neutral gauge bosons masses and the mass of photon is zero.
Pickering emulsions stabilized by some inorganic materials
Authors: Adilbekova Akbota , Yertayeva Ayaulym
Published: March 2021

The paper presents studies of various solid stabilizers of emulsions based on inorganic materials. Inorganic colloidal particles have an advantage for obtaining of stable emulsions due to their safety for use in food, cosmetics, pharmaceutical industry and medicine. Pickering emulsions have a higher biodegradability compared to classical emulsions stabilized with surfactants. An overview of inorganic substances such as silicon dioxide, clay materials, metal and metal oxide nanoparticles, calcium compounds and carbon particles used for stabilizing of Pickering emulsions is considered. A variety of solid inorganic particles as well as modification of their surfaces by surfactants allows to obtain the stable Pickering emulsions of different types for a wide range of applications. It should be noted that despite a large number of studies, this class of disperse systems is still not studied fully; various methods of their preparation and influence of solid particle size on stability and size of emulsions droplets are shown.
Įmonių restruktūrizavimo tikslų analizė
Authors: Bivainis Juozas , Tamošiūnas Andrius
Published: March 2021

Straipsnyje nagrinėjami įmonių restruktūrizavimo Europos Sąjungoje ir JAV tikslai, tiriami Lietuvos finansinių, draudimo paslaugų, energijos išteklių, alaus sektoriuose vykdomo įmonių restruktūrizavimo procesai. Atskleidžiama užsienio kapitalo įtaka restruktūrizuojant šalies įmones. Remiantis užsienio ir Lietuvos įmonių restruktūrizavimo raidos ypatumais, pabrėžiami įmonių restruktūrizavimo aspektai, lemiantys Lietuvos įmonių konkurencingumą bei turintys įtakos Lietuvos verslo plėtrai globalizacijos ir integracijos sąlygomis.
Gestaltungsempfehlung für TQM und KMU
Authors: Duttine Andre , Ginevičius Romualdas
Published: March 2021

Das im Artikel vorgeschlagene Konzept des Qualitätmanagements für Klein-und Mittelunternehmen (KMU) ist aus vier Teilen zusammengestelt: Positionsbestimmung im TQM-Prozess des Unternehmens, Bestimmung der strategischen Komponente des TQM-Prozess, Personalorientierung und Prozessorientierung in der Produktorganisation. Die Grundzüge von diesen Elementen und die Wirkung aufeinander sind angeführt.
E-business Conditions and Perspectives in Lithuanian Enterprises
Authors: Jucevičienė Vilija
Published: March 2021

The article analyses e-business experience and perspectives in agricultural, trading, service and production enterprises in Lithuania. The analysis of literature sources discusses the e-business concept. e-business partners (business, consumer, administration and employees) and communication among them. It analyses the advantages (cost, customer, competition) and shortcomings of e-business (law, security and cost). The practical research of e-business applications and perspectives (hardware, software, internet and data structures) is based on studies of enterprises in Lithuania during 2002.
Inovacijų plėtros Lietuvos pramonėje tyrimas
Authors: Miečinskas Aldas , Miečinskienė Algita
Published: March 2021

Straipsnyje nagrinėjama inovacinė veikla septyniose pramonės šakose, vertinamos ekonominės ir socialinės aplinkybės, turėjusios įtakos inovacijų plėtrai, inovacinių projektų pramonės įmonėse efektyvumas, galimos inovacijų plėtojimo Lietuvoje kryptys ir priemonės. Lietuvoje technologijų plėtra į dalies vyksta dėka pramonės įmonėse įgyvendinamų inovacinių projektų, kurių struktūra ir dinamika pradėta tyrinėti neseniai. Straipsnio tikslas – atlikti inovacijų plėtros tendencijų Lietuvos įmonėse tyrimą ir nustatyti ūkio subjektų inovacines iniciatyvas ribojančius ir skatinančius veiksnius Lietuvoje. Šio tyrimo rezultatai naudotini formuojant Lietuvos nacionalinę inovacijų sistemą, skirtą aktyvinti inovacijų verslą. Tyrimo duomenys surinkti atlikus įmonių vadovų anketinę apklausą. Inovacijų pramonės įmonėse dinamikos analizė buvo atlikta vertinant kai kurių rodiklių lyginamąjį svorį, vertinant apyvartos didėjimo tikimybę priklausomai nuo projekto vertinimo detalumo. Atliktų septynių pramonės šakų inovacinės veiklos lyginamoji analizė.
Текстологическая семья Мстиславова евангелия: новые данные о группировке древнерусских списков полного апракоса
Authors: Юрьевич Темчин Сергей
Published: March 2021

В даннoй работе предлагается предварительная классификация 86 восточнославянских списков служебного Евангeлия XII-XVII вв., составляющиx текстологическую семью Мстиславова евангелия. Рукописи даннoй семьи выявлены на основании характерной текстологической приметы – наличии в стихе Мф 5.22 интерполяции, обьясняющей иноязычное слово рака. Публикуется полная коллация текста чтения на среду недeли Пятидесятницы (Мф 5.20–26), в котором представлена указанная интерполяция, по всем выявленных спискам. Предложенная формальная классификация рукописей основана на результатах анализа разнокоренных лексических вариантов.
К изучению особеннoстей литургического произношения cтaрообрядцев Литвы
Authors: Афанасьевна Морозова Надежда
Published: March 2021

В 1999 г. исполняется 320 лет с тех пор, когда, согласно старообрядческой летописи, на территории Литвы появился первый сторонник “древлеправославного благочестия”: “В сем году 1679-м прииде в Литву от страны Московския муж именем Трофим Иванов, бывший в царствование Алексея Михайловича военнослужащий стрелецкой десятник под командою воеводы Мещерина, посланного разорить соловецкую киновию, при котором будучи самолично видевший разорение святой обители и страдание преподобных отец соловецких за древлеправославное свято отеческое благочестие и от того самовидения прииде в великое умиление, раскаявся о своем зверском немилосердии к святым отцам. Тогда утаився от всех, оставляет российское отечество, приходит в Литовскую землю и водворивися ту, пребысть до кончины своея...” [ДЛ, 187]. Спустя 30 лет, по данным той же летописи, был построен первый молитвенный дом: “В сем 1710-м году моленна в Пущи, яже есть Кревенская устроися в начале 18-го столетия, до рижского взятия, в царствование Петра Алексеевича 1-гo, и при ней настоятельство благословением Афанасия Терентьича” [там же, 190].
Словенская лингвистическая литература за 1994–1998 гг.
Authors: Коницкая Елена
Published: March 2021

В обзоре рассматриваются монографические исследования и издания, но не материалы периодических изданий (таких, как Slavistična revija, Jezik in slovstvo, сборники Sеminar slоvеnskеgа jеzika, literature in kulture, ежегодных совещаний славистов и др.). Исключение составляет один из номеров сборника Traditiones Института этнографии Академии наук и искусств Словении, так как он, в отличие от других сборников данной серии, посвящен в основном проблемам языка.
Precious Metals in the Worldview System of Ancient Iranian-Speaking Peoples on the Texts of Avesta
Authors:   National Academy of Sciences of Ukraine, A. Yu. Krymskyi Institute of Oriental Studies, PhD (in History), Research Fellow, Vertiienko Hanna
Published: March 2021

An overview and contextual-semantic analysis of the cases of usage the lexeme ‘gold’ (zaraniia-) and ‘silver’ (ərəzata-) in corpus of Avestan sources (Yasna, Yashts, Videvdat, Aogəmadaēca, etc.) are provided in the article. ‘Gold’ is used in the Avesta 101 times. ‘Silver’ — only 12 uses, while this metal is always contextually linked with gold. Silver has a semantic connection with the aquatic sphere. Gold is the material from which, according to the texts, the garments of several deities are made (Vayu, Aredvi Sura (partially)). Gold attributes or decorated with this metal tools have a number of gods and heroes (Yima, Mithra, Verethragna, Tishtria, Sraosha) are made completely or partially from it. In the myth of Yima, the divine instruments, the golden suβrā and gilded aštrā, are endowed with reproductive features and help to create the first kingdom (Videvdat 2.6—38). This ideal mythical world turns into the Afterworld. A set of semantic attributes show that gold is directly related to the Otherworld, where the souls of the righteous deceased receive gold places, golden or silver clothes (Videvdat 19.31—32; Aog. 12, 17). The fact that silver and other «colors» are added to gold may indicate the expansion of the spectrum of precious metals and their penetration into the sphere of funeral beliefs. In the treatise of Aogəmadaēca (84), silver-gold (a metaphor of wealth), along with cattle, horses and bravery, is included in the system of concepts related to the Thanatological worldview of the pre-Zoroastrian representations of ancient Iranian tribes.
New Materials From Excavation «Orient» at Olbian Necropolis
Authors:   National Academy of Science of Ukraine, Institute of Archaeology, Classical Archaeology Department, Junior Research Fellow, Ivchenko Andrii
Published: March 2021

At the excavation site in Olbia in 2010—2019 a new sector was investigated in wide areas, which was called the «Orient» after the name of the nearest benchmark. The specific features of this site were established, which was used for burials from the middle of the VI c. BC before the beginning of the III c. AD. In this regard, the generalization of the results obtained has become relevant, as well as the introduction of finds from the Roman period into the scientific circulation. In total, 1064 m2 were uncovered during the research. The average depth was 1,0—1,1 m from the modern surface. The stratigraphy of the excavation is simple: a layer of turf and humus up to 0,2 m thick lies on top, below there is a layer of light (dark yellow) sandy loam with various impurities, and under it is a layer of red-colored pre-continental loam with separate inclusions of «white-eye». In this area, 70 burials of various types of different time periods were discovered, as well as 62 other objects associated with the funeral and memorial tradition. 24 burials and ten other objects are dated by the Roman period. Eight types of burial structures have been identified. Based on this, the following conclusions were identified. In the Roman period, rare types of burial structures appeared in the area under study, in number greater than in the rest of the necropolis. There is a lack of uniformity in the layout and direction of burials. The memorial sites are characterized by the complete absence of gravestones known at Olbian necropolis of the Roman period.
Sistem Informasi Spasial Berbasis Web pada Sebaran Sarana Perumahan dan Permukiman (Studi kasus)
Authors: Saputra Muhammad Dedy , Arham Zainul
Published: March 2021

Kota Sekayu merupakan wilayah perkotaan yang menjadi pusat Pemerintahan Kabupaten Musi Banyuasin. Terjadinya peningkatan jumlah penduduk yang terus menerus, menunjukan bahwa pemerintah setempat hendaknya membangun berbagai sarana perumahan dan permukiman. Berdasarkan Permendagri Nomor 9 Tahun 2009 disebutkan bahwa penyerahan sarana perumahan dan permukiman harus berdasar kepada prinsip keterbukaan dimana masyarakat mengetahui dan diberi kemudahan untuk mengakses informasi sarana perumahan dan permukiman. Oleh karena itu, Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kabupaten Musi Banyuasin pada bidang penelitian dan pengembangan bertugas memetakan sarana perumahan dan permukiman akan tetapi masih terdapat kendala pada sistem pengelolaan data yang masih statis, tidak terpusatnya data, belum adanya koordinat geografi, dan minimnya informasi yang didapat masyarakat tentang sarana perumahan dan permukiman. Penelitian ini bertujuan untuk menyediakan sistem informasi spasial yang dapat mengelola sebaran sarana perumahan dan permukiman di Kota Sekayu. Dalam penelitian ini digunakan bahasa pemrogramana PHP beserta database MySQL. Penelitian ini menghasilkan sistem informasi spasial berbasis web yang dapat digunakan oleh Badan Perencanaan Pembangunan Daerah (BAPPEDA) Kabupaten Musi Banyuasin untuk mengelola persebaran sarana perumahan dan permukiman.
Analisis Usability Sistem Informasi Manajemen Puskesmas (Simpus) dengan Metode Heuristic Evaluation pada Puskesmas 1 Ajibarang
Authors: Ayu Indah Kusuma , Nuryasin Nuryasin
Published: March 2021

SIMPUS merupakan suatu Aplikasi Manajemen Puskesmas dimana fungsi utamanya adalah memanage data pasien mulai dari pendaftaran, registrasi, pemeriksaan (diagnosis) serta pengobatan pasien. Dalam pelaksanaannya, SIMPUS perlu dilakukan evaluasi usability untuk mengetahui kualitas dan masalah usability yang ada dan menjadi acuan untuk perbaikan selanjutnya. Maka dari itu penelitian ini bertujuaan untuk mengevaluasi SIMPUS dan mengetahui tingkat usability pengguna terhadap SIMPUS. Metode yang digunakan dalam penelitian ini adalah Heuristic Evaluation dengan menggunakan skala likert dalam mengevaluasi setiap pertanyaan yang diberikan setiap responden dengan rentang nilai yaitu STS=Sangat Tidak Setuju (dengan nilai 1), TS=Tidak Setuju (dengan nilai 2), S=Setuju (dengan nilai 3), SS=Sangat Setuju (dengan nilai 4). Semakin besar nilai yang dipilih responden maka menunjukkan bahwa tanggapan responden positif dan semakin kecil angka yang dipilih memberikan kesan negatif. Hasil analisis website Sistem Informasi Management Puskesmas menggunakan metode Heuristic Evaluation bahwa Nilai rata-rata Severety Rating 1,65 masuk di skala severaty rating 2 dimana merupakan kategori minor usability problem, perbaikan masalah ini diberikan prioritas yang rendah.
Alternative Etiologies of Liver Disease in Children With Suspected NAFLD
Authors: Yodoshi Toshifumi , Orkin Sarah , Arce-Clachar Ana Catalina , Bramlage Kristin , Xanthakos Stavra A. , Valentino Pamela L. , Mouzaki Marialena
Published: March 2021

OBJECTIVES:

To determine the prevalence of alternative causes of liver disease in a cohort of youth with overweight and obesity undergoing evaluation for suspected nonalcoholic fatty liver disease (NAFLD).

METHODS:

Multicenter, retrospective cohort study of patients aged ≤18 years with overweight and obesity and evidence of elevated serum aminotransferases and/or hepatic steatosis on imaging, referred for suspected NAFLD to Cincinnati Children’s Hospital Medical Center (2009–2017) or Yale New Haven Children's Hospital (2012–2017). Testing was performed to exclude the following: autoimmune hepatitis (AIH), Wilson disease, viral hepatitis (B and C), thyroid dysfunction, celiac disease, α-1 antitrypsin deficiency, and hemochromatosis.

RESULTS:

A total of 900 children with overweight and obesity (63% boys, 26% Hispanic ethnicity) were referred, with a median age of 13 years (range: 2–18). Most had severe obesity (n = 666; 76%) with a median BMI z score of 2.45 (interquartile range [IQR]: 2.2–2.7). Median alanine aminotransferase level at presentation was 64 U/L (IQR: 42–95). A clinically indicated liver biopsy was performed in 358 children (40%) at a median of 6 months (IQR: 1–14) post initial visit; of those, 46% had confirmed nonalcoholic steatohepatitis. Positive autoantibodies were observed in 13% of the cohort, but none met criteria for AIH. Only 19 (2%) were found to have other causes of liver disease, with no cases of viral hepatitis or Wilson disease detected.

CONCLUSIONS:

In a large, multicenter cohort, the vast majority of children with overweight and obesity with presumed or confirmed NAFLD tested negative for other causes of liver disease. In contrast to a previous pediatric report, no patient was diagnosed with AIH.
Adolescent Risk Behavior Screening and Interventions in Hospital Settings: A Scoping Review
Authors: Pfaff Nora , DaSilva Audrey , Ozer Elizabeth , Kaiser Sunitha
Published: March 2021

CONTEXT:

Risky behaviors are the main threats to adolescents’ health; consequently, evidence-based guidelines recommend annual comprehensive risk behavior screening.

OBJECTIVE:

To review studies of adolescent risk behavior screening and interventions in urgent care, emergency department (ED), and hospital settings.

DATA SOURCES:

Our data sources included PubMed (1965–2019) and Embase (1947–2019).

STUDY SELECTION:

Studies were included on the basis of population (adolescents aged 10–25 years), topic (risk behavior screening or intervention), and setting (urgent care, ED, or hospital). Studies were excluded if they involved younger children or adults or only included previously identified high-risk adolescents.

DATA EXTRACTION:

Data extracted were risk behavior screening rates, screening and intervention tools, and attitudes toward screening and intervention.

RESULTS:

Forty-six studies were included; most (38 of 46) took place in the ED, and a single risk behavior domain was examined (sexual health [19 of 46], mood and suicidal ideation [12 of 46], substance use [7 of 46], and violence [2 of 46]). In 6 studies, authors examined comprehensive risk behavior screening, demonstrating low rates at baseline (∼10%) but significant increases with clinician reminder implementation. Adolescents and clinicians were highly accepting of risk behavior screening in all settings and preferred electronic screening over a face-to-face interview. Reported barriers were time constraints and limited resources.

LIMITATIONS:

Only 1 included study was a randomized controlled trial, and there was large heterogeneity of included studies, potentially limiting generalizability.

CONCLUSIONS:

Rates of adolescent risk behavior screening are low in urgent care, ED, and hospital settings. Our findings outline promising tools for improving screening and intervention, highlighting the critical need for continued development and testing of interventions in these settings to improve adolescent care.
Can Parents Restrict Access to Their Adolescent’s Voice?: Deciding About a Tracheostomy
Authors: Lanocha Natalie , Tate Tyler , Salter Erica , Elster Nanette , Antommaria Armand H. Matheny
Published: March 2021

Parents are the default decision-makers for their infants and children. Their decisions should be based on the best interests of their children. Differing interpretations of children’s best interests may be a source of conflict. Providers’ biased evaluations of patients’ quality of life may undermine medicine’s trustworthiness. As children mature, they should participate in medical decision-making to the extent that is developmentally appropriate. In this month’s Ethics Rounds, physicians, a philosopher, and a lawyer consider parents’ demand, supported by the hospital’s legal department, that their 17-year-old son be excluded from a potentially life-and-death medical decision.
Progression of language and cognitive impairment in patients with the logopenic variant of primary progressive aphasia – case series
Authors:   Instytut Logopedii, Wydział Filologiczny, Uniwersytet Gdański, Gdańsk, Polska, Kluj-Kozłowska Klaudia ,   Centrum Diagnozy i Terapii Neurologopedycznej, Gdańsk, Polska, Sitek Emilia J. ,   Zakład Pielęgniarstwa Neurologiczno-Psychiatrycznego, Wydział Nauk o Zdrowiu z IMMiT, Gdański Uniwersytet Medyczny, Gdańsk, Polska,   Oddział Neurologii, Szpital Specjalistyczny św. Wojciecha, Copernicus Podmiot Leczniczy, Gdańsk, Polska, Skrzypkowska Agnieszka ,   Wydział Nauk o Zdrowiu z IMMiT, Gdański Uniwersytet Medyczny, Gdańsk, Polska, Narożańska Ewa ,   Poradnia Zaburzeń Pamięci, Szpital Specjalistyczny św. Wojciecha, Copernicus Podmiot Leczniczy, Gdańsk, Polska, Brockhuis Bogna ,   Zakład Medycyny Nuklearnej, Wydział Nauk o Zdrowiu z IMMiT, Gdański Uniwersytet Medyczny, Gdańsk, Polska, Sławek Jarosław ,   Zakład Pielęgniarstwa Neurologiczno-Psychiatrycznego, Wydział Nauk o Zdrowiu z IMMiT, Gdański Uniwersytet Medyczny, Gdańsk, Polska,   Oddział Neurologii, Szpital Specjalistyczny św. Wojciecha, Copernicus Podmiot Leczniczy, Gdańsk, Polska, Domagała Aneta ,   Katedra Logopedii i Językoznawstwa Stosowanego, Wydział Humanistyczny, Uniwersytet Marii Skłodowskiej-Curie, Lublin, Polska, Milewski Stanisław ,   Instytut Logopedii, Wydział Filologiczny, Uniwersytet Gdański, Gdańsk, Polska
Published: March 2021

Aim: The paper presents longitudinal observation of four patients diagnosed with the logopenic variant of primary progressive aphasia (lvPPA). Materials and methods: The results of 3–4 language and cognitive assessments were available for four individuals (three women, one man) with lvPPA. The length of the observation period was 2–4 years. Language evaluation was comprehensive and addressed narrative speech, naming, word and sentence comprehension, repetition, reading and writing. Neuropsychological examination, whenever feasible, assessed visuospatial function, praxis, memory and executive functions. Results: Anomia was not an isolated symptom at the time of lvPPA diagnosis. Rapid deterioration of both spoken and written communication was observed. Reading aloud single words and high-frequency word comprehension were preserved longer than other linguistic competences. The narrative speech was progressively impoverished in terms of idea density, manifested by a reduced use of nouns and verbs in particular and an increased use of pronouns. At the advanced stage of the disease, the idea density was very low. There was marked deterioration of visuospatial functions, praxis and episodic memory in all patients. Progression to full-blown dementia was observed in all patients. Conclusions: The progression of linguistic and cognitive symptoms in lvPPA, albeit slightly heterogeneous, is relatively fast. The patients usually reach dementia stage within 1–2 years of the diagnosis and sometimes even earlier than 2 years of the declared symptom onset. When planning long-term management of lvPPA cases, rapid deterioration and progression to full-blown dementia within a relatively short time should be considered.
A krónikus lymphoid leukaemia mai kezelésének interdiszciplináris kérdései
Authors: Szász Róbert , Illés Árpád
Published: March 2021

Összefoglaló. A Bruton-féle tirozin-kinázt gátló ibrutinib és a
B-sejtes lymphoma-2-t gátló venetoklax a krónikus lymphoid leukaemia (CLL)
kezelésének egyre korábbi vonalában alkalmazható, és ezek mellett a
progressziómentes túlélés növekedése figyelhető meg. A célzott kismolekulákkal
végzett kezelés nemcsak a CLL lefolyását, de a betegek gondozását is alapvetően
megváltoztatta. A tartósan adagolt orális szerek mellett a betegek nagyobb
valószínűséggel jelennek meg a panaszaiknak megfelelő szakrendeléseken. Az új
típusú szerek hatásai és mellékhatásai mellett az alapvető
gyógyszer-interakciókra is fel kell hívni a figyelmet. Kiemelt fontosságú az
ibrutinib hypertoniát provokáló hatása, illetve a 6–16%-ban megjelenő
pitvarfibrilláció. Ez utóbbi ellátását a gyógyszer-interakciókon túl az
ibrutinib vérzékenységet okozó hatása is nehezíti. A CLL-lel, illetve annak
kezelésével kapcsolatos ismeretek a másodlagos daganatok, néhány
gastrointestinalis és bőrgyógyászati betegség megközelítése szempontjából is
fontosak. A venetoklax mellett potenciálisan kialakuló tumorlízis-szindróma
alkalmanként a nefrológusok bevonását igényli. A betegek gondozása, megfelelő
szakszerű ellátása és a betegutak optimalizálása érdekében a háziorvosok, a
sürgősségi ellátók és az egyéb szakellátó helyek szoros együttműködése szükséges
szakorvosi konzultáció keretei között. Orv Hetil. 2021; 162(9): 336–343.

Summary. Chronic lymphocytic leukemia (CLL) is ubiquitously treated
with novel agents. The Bruton’s tyrosine kinase inhibitor ibrutinib and the
B-cell lymphoma 2 inhibitor venetoclax can be used increasingly in earlier lines
of treatment with improved progression-free survival. Treatment with targeted
small molecules fundamentally changed not only the course of CLL but also the
care of patients. With the administration of long-term oral medications,
patients are more likely to show up at specialist clinics that match their
complaints. In addition to the effects and side effects of the new drugs,
attention should also be drawn to basic drug interactions. The effect of
ibrutinib on blood pressure and the ability to provoke atrial fibrillation in
6–16% of cases are of paramount importance. In addition to drug interactions,
the treatment of the latter is also complicated by the hemorrhagic effect of
ibrutinib. Knowledge on CLL and its treatment is also important in the approach
to secondary tumors, some gastrointestinal and dermatological diseases. The
potential for tumor lysis syndrome of venetoclax requires close collaboration
with nephrologists. In order to provide appropriate professional care and
optimize patient pathways, close co-operation between GPs, emergency care
providers and other specialist care facilities is required within the framework
of professional consultation. Orv Hetil. 2021; 162(9): 336–343.
Meibom-mirigy-diszfunkció és a száraz szem
Authors: Kovács Balázs , Láng Boglárka , Takácsi-Nagy Anna , Horváth Györgyi , Czakó Cecília , Csorba Anita , Kiss Huba , Szalai Irén , Nagy Zoltán Zsolt , Kovács Illés
Published: March 2021

Összefoglaló. A szárazszem-panaszok hátterében gyakran áll
Meibom-mirigy-diszfunkció, melynek felismerése kiemelten fontos a hatékony
kezelés érdekében. A Meibom-mirigyek kóros működése miatt a termelt lipid nem
oszlik el megfelelően a szemfelszínen, így a könnyfilm párolgása fokozódik. A
könnytermelési zavar következtében szárazszem-panaszok alakulnak ki, melyek a
hagyományos könnypótló kezelésre rendszerint csak átmenetileg javulnak. A
Meibom-mirigy-diszfunkciót gyakran kíséri a szemhéjszél
Demodex-atka-fertőzése – az atka eradikálása szükséges a
mirigyek működésének helyreállításához és ezáltal a panaszok megszüntetéséhez. A
Meibom-mirigy-diszfunkció a leggyakrabban enyhe formában jelentkezik; a terápia
ilyenkor a beteg által is elvégezhető szemhéjtisztításból áll, míg a gyógyszeres
kezelés csak az előrehaladottabb, kifejezett gyulladással járó formákban
szükséges. Az összefoglaló áttekinti a Meibom-mirigy-diszfunkció klinikai
jeleivel és kezelésével kapcsolatos legfontosabb tudnivalókat, különös
tekintettel a Demodex-fertőzés felismerésére és kezelésére
vonatkozóan. Orv Hetil. 2021; 162(2): 43–51.

Summary. The onset of dry eye complaints is often a result of
Meibomian gland dysfunction and its diagnosis is essential for effective
treatment. In the case of Meibomian gland dysfunction, there is an increased
evaporation of the tear film due to the abnormal secretion of lipids that cannot
spread on the ocular surface. The treatment of dry eye complaints associated
with Meibomian gland dysfunction with tear supplementation is usually
ineffective and only results in an intermittent relief of complaints. Meibomian
gland dysfunction is often associated with Demodex infestation
of the eyelids, and eradicating the mites is essential to re-establish normal
meibum production and thus, decreasing ocular complaints. In most cases,
Meibomian gland dysfunction is mild, and the treatment of these forms is based
on ocular hygiene performed by the patient, while only more advanced forms with
inflammatory processes require pharmacologic treatment. This review summarizes
the most important knowledge on the clinical signs and treatment of Meibomian
gland dysfunction with particular attention to the diagnosis and treatment of
ocular Demodex infection. Orv Hetil. 2021; 162(2): 43–51.
Plakkmodifikáció a 21. században – az első magyar tapasztalatok az intravascularis lithoplasticával
Authors: Németh Balázs Tamás , Édes István Ferenc , Szilveszter Bálint , Nowotta Fanni , Becker Dávid , Merkely Béla
Published: March 2021

Összefoglaló. A nagy mésztartalmú plakkok által okozott szűkületek
percutan intervenciója az esetek egy részében a jelenleg széles körben elérhető
megoldások alkalmazásával technikailag nem kivitelezhető. A procedurális
sikertelenség vezető oka a meszes laesiók kalciumtartalom miatti fokozott
ellenállása a ballonos dilatációkkal szemben, mely lehetetlenné teszi a
szükséges sztentek levezetését is. Az ilyen laesiók mésztartalmának csökkentését
célzó hagyományos plakkmodifikációs eljárások – mint a rotablatio, a vágó- és
ultranagy nyomású ballonok – sem jelentenek megoldást minden esetben, különösen
az érfal átmérőjének legalább 50%-át elérő, akár körkörösen jelen lévő
meszesedés fennállása esetén. A közelmúltban éppen ezen laesiók mésztartalmának
feltördelésére, így a sztentek deponálásának elősegítésére kifejlesztett
módszert a szakirodalom intravascularis lithoplastica néven említi. A jelen
közleményben a Klinikánkon eddig 4 beteg rendkívül meszes laesióinak jó
angiológiai eredményű ellátása során az eszközzel szerzett tapasztalatokat
foglaljuk össze. A végeredményt tekintve az intravascularis lithoplastica
ígéretes új intervenciós lehetőség a masszívan meszes coronarialaesiók
ellátására. Orv Hetil. 2021; 162(2): 69–73.

Summary. Percutaneous intervention of stenoses caused by highly
calcified plaques utilizing the currently widely available methods is not
possible due to technical difficulties in several cases. Increased resistance of
calcified plaques against balloon dilation due to their calcium content plays a
leading role in procedural failure, as stent crossing becomes impossible as
well. Classical methods of plaque modification for debulking the calcification
of such lesions – such as rotablation, cutting and ultra-high pressure
non-compliant balloons – do not resolve this issue, especially when
calcification exceeds 50% of the vessel diameter. A new method, referred to as
intravascular lithoplasty in the literature, has recently been developed to
break the calcium and thus promote stent deployment in such lesions. In our
current work, we summarize the experience gathered with this method during the
treatment of extremely calcified lesions of 4 patients with good angiographic
result. As a conclusion, intravascular lithoplasty is a promising new
interventional method in the treatment of massively calcified coronary lesions.
Orv Hetil. 2021; 162(2): 69–73.