bluuebunny/crossref_metadata_2025 huggingface dataset:
New country and host records for Lithuanian Tachinidae (Diptera)
Authors: Lutovinovas Erikas
Published: August 2019

This paper updates the knowledge on the family Tachinidae (Diptera) in the Lithuanian fauna. As the result, 68 species are first records from the country and eight species are deleted from the previous list. Among species listed in this paper, 54 represent first records for the Baltic States and 16 are new for all of Eastern Europe. Parasitoid-host associations for 13 species of Tachinidae with 15 host taxa that comprise 17 couples are recorded for Lithuania for the first time. Among these, Meigenia uncinatata is a new parasitoid of the leaf beetle Gonioctena quinquepunctata (Chrysomelidae).
Status and monitoring of the buff-tailed bumblebee Bombus terrestris Linnaeus (Hymenoptera: Apidae) in Southern Finland
Authors: Vesterlund Salla-Riikka , Kakko Maria , Vasemägi Anti , Sorvari Jouni
Published: August 2019

Bombus terrestris can cause pollination disturbance in native plants and compete with native bumblebees and other pollinators. The accompanying non-native parasites may also threaten native bees. We report new observations of the commercially used Bombus terrestris (Linnaeus, 1758) using trapping data and sporadic samples identified with a PCR–RFLP-method for degraded DNA. A total of 863 individuals (355 queens, 442 workers, 66 drones) of Bombus sensu stricto were collected during the years 2008–9, of which, 642 were B. lucorum, ten B. cryptarum, four B. terrestris and none were B. magnus. Three trap types were compared in two modified transects near areas that use the commercial B. terrestris for pollination in Southern Finland: the tree trap that was hung at approximately 3 metres height was the most effective. Regular monitoring is important in the risk assessment of B. terrestris, and for correct species identification, molecular methods are recommended.
Feeding on the roof of the world: the first gut content analysis of very high altitude Plecoptera
Authors: Boggero Angela , Bo Tiziano , Zaupa Silvia , Fenoglio Stefano
Published: August 2019

The biology of Plecoptera from high altitude Himalayan freshwaters is almost unknown. Very few and sporadic studies have been devoted to these insects, and exclusively with a taxonomic approach. We provide information on the feeding of Capnia nymphs from three lakes localized above 4,800 m a.s.l. (NE Nepal). Nymphs from these high altitude lakes feed mainly on fine detritus, acting as collector- gatherers, with the accidental ingestion of mineral matter, mostly in larger specimens. It is likely that the harsh environmental conditions in our study area create an environment unfavorable to both the allochthonous input of coarse particulate organic matter (such as terrestrial leaves) and the autochthonous input related to aquatic primary productivity, so that these nymphs feed on small organic particles that originates mainly from the catchment.
Three new species of the Phaonia acerba group (Diptera: Muscidae) from Palaearctic and Oriental Regions
Authors: Yu Teng , Xue Wan-Qi
Published: August 2019

Three new species of the Phaonia acerba group fromthe Palaearctic and Oriental Regions are described: P. gaoligongshanensis Xue & Yu, sp. n., P. zhangxianggi Xue & Yu, sp. n. and P. hongkuii Xue & Yu, sp. n. An identification key to the males of 8 species of the Phaonia acerba group from the Palaearctic and Oriental Regions is provided.
New records of mealybug species in Iran with discussions on morphological variations (Hemiptera, Coccoidea: Pseudococcidae)
Authors: Moghaddam Masumeh
Published: August 2019

The mealybug Vryburgia succulentarum Williams is recorded for the first time from the Palaearctic area (in a greenhouse). In addition, four other species, Artemisia bispinus (Borchsenius), Coccura circumscripta (Kiritchenko), Mirococcus inermis (Hall) and Phenacoccus daganiae (Bodenheimer) are recorded for the first time from Iran. Artemisia bispinus, C. circumscripta and P. daganiae have been reported only from the Palaearctic Region. The third-instar female of M. inermis is described based on specimens collected in Iran. Some characters of A. bispinus, C. circumscripta and M. inermis differ from those in the specimens found elsewhere and are discussed. Illustrations, localities and host plants of the above species are provided.
Descriptions of two new species of Neuroterus Hartig from China (Hymenoptera: Cynipidae)
Authors: Pujade-Villar Juli , Wang Yiping , Liu Zhiwei , Guo Rui
Published: August 2019

Two morphologically unusual new species of Neuroterus Hartig, Neuroterus sculpturatus Pujade-Villar & Wang sp. n. and N. abdominalis Pujade-Villar & Wang sp. n., are described fromChina. Data about galls, distribution and biology of the new species are included. Taxonomic problems concerning some of the Palaearctic Neuroterus species, including the species described here, are also commented.
Seasonal dynamics of common ground beetles (Coleoptera: Carabidae) along an urbanisation gradient near Sorø, Zealand, Denmark
Authors: Elek Zoltán , Howe Andy , Enggaard Mattias , Lövei Gábor
Published: August 2019

The seasonal activity of six carabid species (Nebria brevicollis, Carabus nemoralis, C. hortensis, C. coriaceus, Pterostichus melanarius and Abax parallelepipedus) was studied along an urbanisation gradient (rural forest – suburban forest – forest fragments in urban park) in Sorø, Denmark, during April–October 2004 and 2005.Two groups were identified: 1) Species with constant seasonality, in which seasonal activity profiles did not differ along the gradient (C. hortensis, C. coriaceus, and A. parallelepipedus); 2) Species with flexible seasonality,with remarkable differences along the gradient and between the years (C. nemoralis, N. brevicollis and P. melanarius). In four out of six studied species, 2005 was less favourable than 2004. Spring activity in the urban habitat started earlier than in the suburban or forested ones. A better understanding of urban green infrastructures in biodiversity assessments may need the study of seasonality in order to distinguish whether the bioindicator’s responses are to habitat quality or stochastic seasonal events.
Springtails (Collembola) in meadows, pastures and road verges in Central Finland
Authors: Komonen Atte , Kataja-aho Saana
Published: August 2019

Understanding of species distribution, abundance and habitat affinities is crucial for red-list assessment, conservation and habitat management. In Central Finland, we studied Collembola in three habitat types, namely non-grazedmeadows, pastures and road verges using pitfall traps. Altogether, 9,630 Collembola individuals were recorded. These belonged to 12 families, 34 genera and 60 species. The number of specimens was clearly higher in meadows than in pastures or road verges. The number of species, however, was higher in meadows and road verges (40 and 39 species, respectively) than in pastures (33 species). The overall species number is comparable to other large-scale sampling schemes in similar habitats. We recorded a few abundant species (Spatulosminthurus flaviceps, Sminthurus viridis and Sminthurus nigromaculatus) that have been previously recorded from very different biotopes. In conclusion, biodiversity inventories of soil fauna, as well as other biota, should also include marginal habitats, which often host peculiar communities.
Revision of Hycleus solonicus (Pallas, 1782) (Coleoptera: Meloidae, Mylabrini), with larval description and DNA barcoding
Authors: Pan Zhao , Bai Qian-Qian , Wang Jue , Ren Guo-Dong
Published: August 2019

Hycleus solonicus (Pallas, 1782), referred to H. polymorphus species group, is revised. Adults are redescribed and illustrated, eggs and first-instar larvae are described and illustrated for the first time, COI sequence for DNAbarcoding is reported for the first time, the geographical distribution is revised and all available faunistic records from the literature and collections are summarized. In addition, two incorrect determinations are pointed out and Zonabris solonica var. dianae Sahlberg, 1913 is proposed to be a synonym of Hycleus scabiosae (Olivier, 1811).
Upacara Tantulak Ambun Rutas Matei Pada Masyarakat Hindu Kaharingan (Persfektif Hukum Hindu)
Authors: Mariatie Mariatie
Published: August 2019

Upacara kematian di kalangan umat Hindu Kaharingan yang disebut dimulai dengan proses perawatan jenazah, penguburan secara ritual dan proses tantulak Ambun Rutas Matei. Upacara tantulak Ambun Rutas Matei dilakukan tiga hari setelah upacara penguburan dengan tujuan untuk mengantarkan arwah Liau Haring Kaharingan dari lewu pasahan raung menuju Bukit Nalian Lanting tempat penantian bersama Nyai Bulu Indu Rangkang untuk sementara ditiwahkan dan sekaligus membersihkan keluarga duka dari sial atau rutas kapali belum artinya dari segala pantangan hidup yang mengakibatkan kematian, hidup sial, segala macam penyakit yang menimpa keluarga.  Selain itu, upacara tantulak juga bertujuan untuk memulihkan keseimbangan magis, menjauhkan segala macam marabahaya dan menghilangkan segala kemalangan atau kesialan dan hal-hal yang tidak baik yang dapat timbul pada keluarga Tarantang Nule (keluarga duka) maupun pada seluruh warga di kampung.

Adanya upacara Tantulak Ambun Rutas Matei ini berawal dari proses Kematian manusia dimuka bumi ini (Lewu Injam Tingang Rundung Nasih Napui Burung) sebagai tempat sementara untuk kehidupan keturunan Raja Bunu.
Pendampingan Pembuatan Kerajinan Tangan Dari Kain Flanel Sebagai Usaha Kecil Menengah (UKM) Masyarakat Di Kelurahan Sei Langkai
Authors: Gusmania Yesi , Amelia Fitrah
Published: August 2019

Pengabdian masyarakat ini bertujuan sebagai salah satu kegiatan untuk dapat meningkatkan kemampuan masyarakat dalam menunjang perekonomian keluarga sebagai usaha kecil Menengah (UKM). . Berdasarkan survey  lapangan  dengan masyarakat RW 02 kelurahan sei langkai bahwa tingkat kesejahteraan masyarakat di Kavling Nato masih tergolong rendah, hal ini terlihat dari 50 % dari total jumlah penduduk  di Kavling Nato termasuk ke dalam pra Keluarga Sejahtera. Selain itu, di Kavling Nato khususnya RW 02 masih banyak Ibu-ibu sebagai rumah tangga yang cenderung tidak mempunyai keahlian atau kegiatan sampingan. Hal ini disebabkan karena kurangnya kreativitas dalam melatih pola pikir masyarakat sewbagai runtinitas sehari-hari. Salah satu cara yang digunakan untuk meningkatkan minat masyarakat, dengan memberikan motivasi dan semangat untuk ibu-ibu dalam mengembangkan usaha kecil menengah (UKM) terutama pembuatan kerajinan tangan dalam menunjang perekenomian keluarga. Hasilnya menunjukkan bahwa: (1). Masyarakat sangat antusias dan semanagat, ketika ibu-ibu diberikan keterampilan kerajinan tangan  dan direspon dengan baik. (2). Pelaksanaan program pengabdian pada masyarakat ini sangat bermanfaat bagi masyarakat, sehingga dapat dilaksanakan  oleh warga di kavling nato sei langkai.
KESEJAHTERAAN PSIKOLOGI ISTRI PERTAMA DALAM PERNIKAHAN POLIGAMI
Authors: Mawardah Mutia , Rostanti Siti Rohma Rostanti
Published: August 2019

This study aims to know the welfare of the psychology of the first wife in polygamy marriage. What factors affect the psychological welfare of a first wife in polygamy, as well as what causes a wife in polygamy. This research uses qualitative research design as well as using and using a case study approach to be able to know the welfare of the psychology of the first wife in polygamy marriage. In this study, researchers used 7 people sources, 2 people as the subject of research, 4 people as informant know of each subject and 1 person as the informant of the perpetrator. The results of this study found that the cause of both subjects in polygamy were among men's riches, consideration of the nobility, and religious considerations. The subjects in this study also had different psychological welfare. The first subject has six-dimensional welfare psychology, while the second subject has only four of the six dimensions of psychological wellbeing. Every dimension that belongs to the subject is also influenced by factors such as religious and social support factors
A synopsis of dated entries in the biological collecting notes from eastern and northern Australia made by Robert Brown (1773–1858) on theInvestigator voyage of 1801–1805
Authors: MOORE D. T.
Published: August 2019

ABSTRACT:

Manuscript notes made by Robert Brown in eastern and northern Australia formed the basis of later descriptions copied up on to his descriptive botanical slips. In some cases they also provide chronological evidence of his whereabouts when his diary notes are uninformative and also record his initial manuscript names. These names also occur on the original labels of his Australian dried plant gatherings.
Parent Training Programs: An Overview
Authors: Perrault Sarah A. , Masood Ambrin F.
Published: August 2019

Parent training and education is one approach utilized to prevent child maltreatment. The National Registry of Evidence-based Programs and Practices lists 66 different parenting programs which have been reviewed. However, this list does not encompass all of the parenting programs available or utilized. An overview of some of these parent training programs provides a glimpse into the potential objectives that can be achieved, populations the program is most effective with, and the age groups which are focused upon. This constitutes a starting point for agencies and entities, whom are considering implementing a parenting program in their community.
Construct a Total Safety Performance for Semiconductor Industry
Authors: Liu Yu-Jung , Lin Hsiu-Chuan , Cheng Shyh-Yueh , Chang Yueh-Ching , Hsiao Ching- Hsiang
Published: August 2019

By referring to the approaches of a safety performance evaluation and the corresponding aspects developed in past studies and also adopting the management mechanisms suggested in the Taiwan Occupational Safety and Health System guidelines, this study constructs the “Total Safety Performance Evaluation Method.” and a safety performance questionnaire is designed by utilizing a semiconductor business in Taiwan as the subject to understand the current status of safety performance in the semiconductor industry by a statistical analysis of the outcome of the questionnaire survey.

The outcome reveals that the employees of the semiconductor business consider that the safety performance evaluation conducted for the elements of “worker participation,” “risk assessment,” “procurement management,” “work permission,” and “safety protection” is not well executed; however, it is well executed for the elements of, in descending order, “health examination,” “emergency response,” “safety audit,” and “management of hazardous substances.” The answers given in the questionnaire indicate that the employees are not enthusiastic about participating in safety promotion activities but confirm that the company conducts health examination on a regular basis.
Conceptual Approaches in the Prevention of Child Overweight in Germany: Project SkAP
Authors: Raimund Geene , Birgit Babitsch , Holger Hassel , Thomas Kliche , Peter Paulus , Eike Quilling , Waldemar Suess , Ulla Walter , Kevin Dadaczynski
Published: August 2019

Childhood overweight and obesity together with related diseases are one of the most serious public health challenges of the 21st century. Since the prevention of overweight and obesity is given a high priority, there is a complex landscape of interventions with multiple subjects, targets groups, and approaches for different settings in Germany. In order to provide a systematic overview, the research project Systematization of Conceptual Approaches for the Prevention of Child Overweight in Settings (SkAP) developed as a first step a catalogue of descriptive indicators to analyze the conceptual approaches of interventions on overweight and obesity prevention in childhood and adolescence. In sum, all indicators can be assigned to five global dimensions: (1) setting, (2) conceptual approach, (3) target group, (4) quality requirements for the conception of universal prevention (in generic and setting-specific), and (5) determinants of childhood and adolescent overweight and obesity. These dimensions were used in the second project step to analyze overweight prevention programs in four settings in order to systemize the applied conceptual approaches. This in turn was the basis for the third step of the research project, which entailed identifying gaps, improvement potential, and recommendations for action.

This project contributes to the improvement of childhood overweight and obesity prevention measures by focusing on setting-specific approaches to health promotion and prevention. First of all, it provides a systematic overview of the approaches in three settings and a field, which allows an in-depth overview at both a generic and setting-specific level. Recommendations focused on gaps in the scientific evidence concerning the implementation and transparency of these prevention measures and include increasing coordination, developing checklists, and creating an intervention database. The results of the SkAP project can be used in the quality-oriented development of intervention measures, which could make it valuable for the implementation of the new German Preventive Health Care Act.
Source of Stress in Sport: A Rasch Calibration
Authors: Williams Christine , Stone Ramona , Ryu Seungho
Published: August 2019

The purpose of this study was to assess the psychometric properties of a stress in sport inventory by determining optimal categorization and model-data fit, and calibrate the sources of stress items associated with individual and team sport athletes using Rasch modeling. The study examines the intensity level of various sources of acute stress experienced by competitive athletes. The Sources of Stress in Sport Inventory (SSSI) was generated to measure intensity level of perceived stress in sport. A total of 336 college-aged males (N=167) and females (N=169) who previously competed in high school or college sports participated. Function of the rating scale was tested to determine if the 5 original rating scale categories were the best fit. Intensity levels of stress items for the athletes were analyzed. The existing 5 rating scale categories functioned well. The top three items of intense acute stress were making a physical or mental error (logits= -0.56), being injured and playing in pain (logits= -0.35), and receiving a "bad" or "unfair" call from the referee/umpire (logits= -0.25). Results support SSSI as an effective scale assessing acute stress in sport among college students. Researchers must continue to understand the sources of stress in sport among athletes using effective inventories so that coaches and health educators can address effective coping and stress management mechanisms and healthy behavioral changes.
Trends in State and Federal OSH Enforcement
Authors: Klyza James P. , Pinion Clint , Brown D Gary
Published: August 2019

Background: OSHA evaluates State Occupational Safety & Health (OSH) enforcement annually through the Federal Annual Monitoring Evaluation (FAME) process. This process is used to determine whether Kentucky OSH (KY OSH) is meeting or exceeding OSHA performance. The FAME report for KY OSH based its evaluations on only 14.5% of the total number of cases in 2015 and did not test for statistical significance.

Objective: Determine the statistical significance of the 2015 FAME report deficiencies in the KY OSH program.

Method: The OSHA dataset consists of case detail for all inspections conducted from 1970 to present (updated daily). ANOVA (analysis of variance) regressions were performed to test the FAME trends for significance. The SAS 9.4 computer program was used for all statistical analysis.

Results: The models are either quadratic or linear regression trends from 1970 to 2016. Total, health, and safety inspections decreased in federal OSHA and KY OSH. Federal and KY number of violations for all safety or construction inspections decreased. Federal and KY number of violations per health inspection decreased. Federal and KY lapse time for all health inspections decreased per year. There was a decrease in willful violations cited by KY, not federal. The adjusted R-squared values explained from 0.3% to 59% of the variance, model power estimates varied from 50% to >99.9%, and the p-values ranged from <0.014 to <0.0001.

Conclusion: Overall, this study did not concur with the FAME Report. Since the OSH Act, effective enforcement may have led to decreased un-programmed activity through increased compliance.
THE ROLE OF BIOLOGICAL MARKERS IN THE DIAGNOSIS OF POSTOPERATIVE INFECTIONS IN COLORECTAL CANCER SURGERY (review)
Authors: Achkasov S. I. , Sukhina M. A. , Moskalev A. I. , Nabiev E. N.
Published: August 2019

Infectious complications in colorectal cancer surgery is one of the major problems in postoperative complications structure. The frequency of the latter is 5-22%, and in 5-20% of cases such complications lead to death. It should be noted that the development of postoperative complications leads to a decrease in the quality of life of patients, general and relapse-free survival of patients operated on for colorectal cancer. One of the promising ways to diagnose postoperative infectious complications after surgery is to assess the level of biological markers of plasma inflammation. It can be used to identify patients with a high probability of infection and be an indication for earlier additional methods of diagnosing complications. Currently, biomarkers that are used for early postoperative infection detection include increase in the leukocytes level in peripheral blood, CRP, PCT, CD64 neutrophils and others. Despite the large number of studies, the question of the role of these biomarkers in postoperative infections diagnosis in the patients who under went colorectal cancer surgery remains unclear.
EFFICACY AND SAFETY OF USTEKINUMAB FOR CROHN’S DISEASE (review
Authors: Shapina M. V. , Nanaeva B. A. , Vardanyan A. V.
Published: August 2019

Crohn's disease (CD) is a chronic autoimmune disease of the gastrointestinal tract, which mainly affects young people of productive age. Until now, patients with this disease cannot be cured with by conservative therapy or surgery. The effectiveness of drugs for CD is limited, and their use is often accompanied by adverse events. All this creates a need for new drugs, fundamentally different in the action, with high efficiency and a good safety profile. The review is dedicated to a new biological agent for the treatment of CD blocking interleukins 12 and 23, which are involved in the pathogenesis of inflammation in inflammatory bowel diseases. This review presents the data of phases 2 and 3 clinical trials of the agent and the data obtained in real clinical practice, allowing to conclude about the efficacy and safety, as well as its place in the treatment algorithm for CD.
SYSTEMS APPROACH FOR ANTIBIOTICS IN COLORECTAL SURGERY IN GROWING ANTIMICROBIAL RESISTANCE BACKGROUND
Authors: Stojko Yu. M. , Gusarov V. G. , Kolozyan D. A. , Levchuk A. L. , Maksimenkov A. V.
Published: August 2019

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Handover-Driven Interference Management for Co-Channel Deployment of Femto- and Macro-Cells
Authors: Yun Ji-Hoon
Published: August 2019

Femtocell technology has been gaining popularity as an inexpensive means of enhancing cellular coverage and capacity. However, under co-channel deployment—expected to be commonplace due to high spectrum costs—femtocells may incur harmful interference to existing macrocells, and vice versa. To alleviate this problem, This paper proposes a new architecture called HandOver-driven Femtocell Interference Management (HO-FIM) that offloads macrocells by handing macrocell users over to “hybrid-access” femtocells that allow the access of both subscribed and unsubscribed users. This use of handovers adds a new degree-of-freedom for solving the interference problem, thus overcoming the capacity limit of the existing approaches that exploit radio resource coordination only. A new challenge associated with this approach is how to minimize handovers while reaching a desired system condition due to the inevitable service interruptions that accompany handovers. This paper proposes to overcome this challenge by triggering handovers only when needed and, once triggered, to find an optimal sequence to reach a target system condition with minimal handovers. This paper designs a greedy per-user control algorithm that has a fine control granularity and thus enables convergence to an optimal solution. The in-depth evaluation of the paper shows that HO-FIM improves the service quality of both macro- and femtocell users; in an example simulation scenario, HO-FIM is shown to improve the signal-to-interference and noise ratios (SINRs) of macro- and femtocell users by up to 23.3 and 2.9 dB, respectively, on average, compared to the case of no handovers.
Enhanced Thermal Properties of Zirconia Nanoparticles and Chitosan-Based Intumescent Flame Retardant Coatings
Authors: Rao Tentu Nageswara , Hussain Imad , Lee Ji Eun , Kumar Akshay , Koo Bon Heun
Published: August 2019

Zirconia (ZrO2)-based flame retardant coatings were synthesized through the process of grinding, mixing, and curing. The flame retardant coatings reinforced with zirconia nanoparticles (ZrO2 NPs) were prepared at four different formulation levels marked by F0 (without adding ZrO2 NPs), F1 (1% w/w ZrO2 NPs), F2 (2% w/w ZrO2 NPs), and F3 (3% w/w ZrO2 NPs) in combination with epoxy resin, ammonium polyphosphate, boric acid, chitosan, and melamine. The prepared formulated coatings were characterized by flammability tests, combustion tests, and thermogravimetric analysis. Finally, char residues were examined with scanning electron microscopy (SEM) and energy-dispersive X-ray spectroscopy (EDS). The peak heat release rate (PHRR) of the controlled sample filled with functionalized ZrO2 NPs was observed to decrease dramatically with increasing functionalized ZrO2 NPs loadings. There was an increase in the limit of oxygen index (LOI) value with the increase in the weight percentage of ZrO2 NPs. The UL-94V data clearly revealed a V-1 rating for the F0 sample; however, with the addition of ZrO2 NPs, the samples showed enhanced properties with a V-0 rating. Thermal gravimetric analysis (TGA) results revealed that addition of ZrO2 NPs Improved composite coating thermal stability at 800 °C by forming high residual char. The results obtained here reveal that the addition of ZrO2 NPs in the formulated coatings has shown the excellent impact as flame retardant coatings.
Experimental Study on the Flexural Behavior of an Innovative Modular Steel Building Connection with Installed Bolts in the Columns
Authors: Wang Yongrui , Xia Junwu , Ma Renwei , Xu Bo , Wang Tonglei
Published: August 2019

Modular buildings have the highest levels of precasting in the current building system. There are some defects in present modular connections, such as the difficulties of construction, the weakening of the bearing capacity of beams or columns, and damage to decorations. This paper presents an innovative modular connection with installed bolts in the columns. Two symmetrical monotonous static loading tests were conducted to explore the flexural behavior of the innovative connection. Meanwhile, the moment–rotation relations, destruction process, ultimate bearing capacity, stiffness classification and internal stress distribution were analyzed. The results showed that the specimen S1 with smaller diagonal stiffeners lost its bearing capacity due to the failure of the welding seam, and the extreme moment was 169 kN·m. The failure mode of S2 with large diagonal stiffeners was beam buckling, and the extreme moment was 209 kN·m. The stress of diagonal stiffeners and the join between the upper beam and stiffeners increased rapidly. Stiffeners can increase the stiffness and load-bearing capacity. The connection failures occurred on the beam or beam–column joints, while the connection between modules remained undamaged, which showed that the new connection has a good bearing capacity under the action of bending moment and pressure.
Effect of Mother’s Age and Pathology on Functional Behavior of Amniotic Mesenchymal Stromal Cells—Hints for Bone Regeneration
Authors: Matteo Maria , Beccia Elisa , Carbone Annalucia , Castellani Stefano , Milillo Lucio , Lauritano Dorina , Di Gioia Sante , Angiolillo Antonella , Conese Massimo
Published: August 2019

Human amnion-derived mesenchymal stromal cells (hAMSCs) are used increasingly in regenerative medicine applications, including dentistry. The aim of this study was to evaluate if hAMSCs from aged and pathological mothers could be affected in their phenotype and functional behavior. hAMSCs were isolated from placentas of women aged younger than 40 years (Group 1, n = 7), older than 40 years (Group 2, n = 6), and with pre-eclampsia (Group 3, n = 5). Cell yield and viability were assessed at isolation (p0). Cell proliferation was evaluated from p0 to p5. Passage 2 was used to determine the phenotype, the differentiation capacity, and the adhesion to machined and sandblasted titanium disks. hAMSCs recovered from Group 3 were fewer than in Group 1. Viability and doubling time were not different among the three groups. Percentages of CD29+ cells were significantly lower in Group 3, while percentages of CD73+ cells were significantly lower in Groups 2 and 3 as compared with Group 1. hAMSCs from Group 2 showed a significant lower differentiation capacity towards chondrogenic and osteogenic lineages. hAMSCs from Group 3 adhered less to titanium surfaces. In conclusion, pathology can affect hAMSCs in phenotype and functional behavior and may alter bone regeneration capacities.
Template-Based 3D Road Modeling for Generating Large-Scale Virtual Road Network Environment
Authors: Zhang Xuequan , Zhong Ming , Liu Shaobo , Zheng Luoheng , Chen Yumin
Published: August 2019

The 3D road network scene helps to simulate the distribution of road infrastructure and the corresponding traffic conditions. However, the existing road modeling methods have limitations such as inflexibility in different types of road construction, inferior quality in visual effects and poor efficiency for large-scale model rendering. To tackle these challenges, a template-based 3D road modeling method is proposed in this paper. In this method, the road GIS data is first pre-processed before modeling. The road centerlines are analyzed to extract topology information and resampled to improve path accuracy and match the terrain. Meanwhile, the road network is segmented and organized using a hierarchical block data structure. Road elements, including roadbeds, road facilities and moving vehicles are then designed based on templates. These templates define the geometric and semantic information of elements along both the cross-section and road centerline. Finally, the road network scene is built by the construction algorithms, where roads, at-grade intersections, grade separated areas and moving vehicles are modeled and simulated separately. The proposed method is tested by generating large-scale virtual road network scenes in the World Wind, an open source software package. The experimental results demonstrate that the method is flexible and can be used to develop different types of road models and efficiently simulate large-scale road network environments.
Human Colorectal Cancer Infrastructure Constructed by the Glycocalyx
Authors: Tachi Masahito , Okada Hideshi , Matsuhashi Nobuhisa , Takemura Genzou , Suzuki Kodai , Fukuda Hirotsugu , Niwa Ayumi , Tanaka Takuji , Mori Hideki , Hara Akira , Yoshida Kazuhiro , Ogura Shinji , Tomita Hiroyuki
Published: August 2019

Cancer cells can survive and grow via angiogenesis. An alternative but controversial theory is cancer cells may grow via vasculogenic mimicry (VM), in which the cancer cells themselves construct vessel-like channels that are considered a leading cause of drug resistance. The dynamic functions of the glycocalyx (GCX), a meshwork composed of proteoglycans and glycoproteins that surrounds cell membranes, have been observed in endothelial cells within tumors. However, the actual structural shape formed by the GCX in human patients remains unclear. Here, we visualized the three-dimensional (3D) network structure constructed by bulky GCX in human colorectal cancer (CRC) patients using scanning electron microscopy with lanthanum nitrate staining. The network structure extended throughout the cancer cell nest, opening into capillaries, with a tunnel channel that exhibited a net- and spongy-like ultrastructure. The expression of endothelial and cancer-specific GCX-binding lectins was dramatically increased in the interstitial spaces between cancer cells. Even accounting for the presence of artifacts resulting from sample preparation methods, the intercellular tunnels appeared to be coated with the bulky GCX. Further, this 3D network structure was also observed in the tumors of ApcMin/+ mice. In conclusion, the bulky GCX modifies the network structure of CRCs in human and mice.
Updates on the Role of Molecular Alterations and NOTCH Signalling in the Development of Neuroendocrine Neoplasms
Authors: von Arx Claudia , Capozzi Monica , López-Jiménez Elena , Ottaiano Alessandro , Tatangelo Fabiana , Di Mauro Annabella , Nasti Guglielmo , Tornesello Maria Lina , Tafuto Salvatore
Published: August 2019

Neuroendocrine neoplasms (NENs) comprise a heterogeneous group of rare malignancies, mainly originating from hormone-secreting cells, which are widespread in human tissues. The identification of mutations in ATRX/DAXX genes in sporadic NENs, as well as the high burden of mutations scattered throughout the multiple endocrine neoplasia type 1 (MEN-1) gene in both sporadic and inherited syndromes, provided new insights into the molecular biology of tumour development. Other molecular mechanisms, such as the NOTCH signalling pathway, have shown to play an important role in the pathogenesis of NENs. NOTCH receptors are expressed on neuroendocrine cells and generally act as tumour suppressor proteins, but in some contexts can function as oncogenes. The biological heterogeneity of NENs suggests that to fully understand the role and the potential therapeutic implications of gene mutations and NOTCH signalling in NENs, a comprehensive analysis of genetic alterations, NOTCH expression patterns and their potential role across all NEN subtypes is required.
Chronic Hepatitis E Virus Infection during Lymphoplasmacytic Lymphoma and Ibrutinib Treatment
Authors: Schlevogt Bernhard , Kinast Volker , Reusch Julia , Kerkhoff Andrea , Praditya Dimas , Todt Daniel , Schmidt Hartmut H. , Steinmann Eike , Behrendt Patrick
Published: August 2019

Hepatitis E virus (HEV) is an increasingly recognised pathogen, affecting several hundred thousand individuals in western countries each year. Importantly, the majority of immunocompromised individuals are not able to clear HEV but develop a chronic course of infection. In the case of lymphoma, which is an inherent immunosuppressive disease per se, chemotherapy can even further exacerbate the immunosuppressive status. As the mechanism of HEV chronification is barely understood, it is important to gain knowledge about the influence of chemotherapeutic drugs on the HEV replication cycle to guide rational clinical management of HEV infection in such patients. In this case report, a 70 year old man was diagnosed with lymphoplasmacytic lymphoma. As we observed the occurrence of chronic HEV after treatment with the Bruton’s tyrosine kinase (BTK) inhibitor ibrutinib in vivo, we investigated the influence of BTK signaling and ibrutinib treatment in the HEV replication cycle in vitro. First, we detected an HEV-induced mobilisation of BTK in human liver cells during HEV replication. A moderate antiviral effect against HEV replicating isolates including genotypes 1 and 3 was observed, suggesting that ibrutinib did not support HEV replication in a direct manner. Combinatory treatments of ibrutinib with ribavirin indicated that ibrutinib did not influence the antiviral effect of ribavirin. Taken together, chemotherapy targeting cellular factors for the treatment of lymphomas may be a neglected risk factor for the chronification of HEV. For ibrutinib, despite the upregulation of its target BTK during HEV replication, we observed neither a proviral effect on HEV replication nor an influence on the antiviral effect of ribavirin, suggesting that the chronification of HEV may be favoured by its immunosuppressive effect.
The Arabidopsis MYB96 Transcription Factor Mediates ABA-Dependent Triacylglycerol Accumulation in Vegetative Tissues under Drought Stress Conditions
Authors: Lee Hong Gil , Park Mid-Eum , Park Bo Yeon , Kim Hyun Uk , Seo Pil Joon
Published: August 2019

Triacylglycerols (TAGs), a major lipid form of energy storage, are involved in a variety of plant developmental processes. While carbon reserves mainly accumulate in seeds, significant amounts of TAG have also been observed in vegetative tissues. Notably, the accumulation of leaf TAGs is influenced by environmental stresses such as drought stress, although underlying molecular networks remain to be fully elucidated. In this study, we demonstrate that the R2R3-type MYB96 transcription factor promotes TAG biosynthesis in Arabidopsis thaliana seedlings. Core TAG biosynthetic genes were up-regulated in myb96-ox seedlings, but down-regulated in myb96-deficient seedlings. In particular, ABA stimulates TAG accumulation in the vegetative tissues, and MYB96 plays a fundamental role in this process. Considering that TAG accumulation contributes to plant tolerance to drought stress, MYB96-dependent TAG biosynthesis not only triggers plant adaptive responses but also optimizes energy metabolism to ensure plant fitness under unfavorable environmental conditions.
Outsourcing Strategies of Established Firms and Sustainable Competitiveness: Medical Device Firms
Authors: Paek Byungjoo , Kim Joohyun , Park Joonyoung , Lee Heesang
Published: August 2019

Successful outsourcing strategy is a key enabler of sustainable competitiveness of established firms engaged in technology-intensive business. This study proposes a research framework of a successful outsourcing process composed of resources, dynamic capabilities and created values, from a review of relevant literature and in-depth case study of four leading medical device firms. The research results specify four outsourcing types according to the characteristics of outsourced resources, and their alignment with resources owned by the outsourcer. Each type of outsourcing is positively affected by the outsourcer’s dynamic capabilities, namely sensing, integrating capability, absorptive capability and technology transfer capability. In addition, the significance of the outsourcee’s size according to each outsourcing type is also found. As a result of successful outsourcing experience, the outsourcer can reap the benefits of enhanced dynamic capabilities, i.e., market-oriented innovation, strategic flexibility, agility and increased efficiency, thereby creating a virtuous cycle of sustainable competitiveness in a volatile environment.
Larval Terapi ve Kronik Yaralar
Authors: GAZİ Umut , TAYLAN ÖZKAN Ayşegül , MUMCUOĞLU Kosta
Published: August 2019

İyileşmeyen yaralar
günümüzde halk sağlığı için önemli bir sorun teşkil etmeye devam etmektedir ve
antibiyotiğe dirençli mikroorganizmaların sebep olduğu cilt ve yumuşak doku
enfeksiyon prevalansındaki artış gibi faktörler nedeniyle bugün ilişkili
oldukları vaka sayıları hâlâ artmaktadır. Yara iyileşmesi, genellikle sorunsuz
ilerleyen dört örtüşen fizyolojik aşamadan oluşur: homeostaz, iltihaplanma,
çoğalma ve yeniden şekillenme / olgunlaşma. Bununla birlikte, iyileşmeyen
yaralarda, iyileşme genellikle doku döküntülerinin uzaklaştırılması, lokal
enfeksiyon ve / veya proteazlar gibi yıkıcı ürünlerin yara yatağından
uzaklaştırılması ile alakalı olan enflamatuar fazda durur. Larval terapi (LT) umut
verici tedavi yöntemlerinden biridir ve esas olarak nekrotize edilmiş dokularla
beslenen yeşil şişe sineği Lucilia
sericata'nın dezenfekte edilmiş larvalarının (kurtçukların) kullanılmasını
içerir. LT'nin esas olarak üzerinde en fazla çalışmanın yayımlandığı
debridmanın yanında  dezenfeksiyon ve büyüme
uyarımı ile yara iyileşmesine yardımcı olduğu düşünülmektedir. Kronik yaraların
tedavisi pahalıdır ve LT uygun maliyetli bir alternatif tedavi stratejisi sunar.
Öte yandan, bakteriyel kaynaklı ülserlerin tedavisine ek olarak, mikotik
enfeksiyon ve leishmaniasis ile ilişkili semptomlar için de kullanılabilir.
Günümüzde LT, iyileşmeyen cilt ve yumuşak doku yaralarına karşı FDA onaylı bir
terapidir. Bu derlemede, iyileşmeyen yaraların tedavisinde LT tarafından
kullanılan etki mekanizmaları hakkındaki güncel literatürü özetledik.
Rekürren Aftöz Stomatit Hastalarının Laboratuvar Bulguları
Authors: SEVİMLİ DİKİCİER Bahar , YALDIZ Mahizer , AYDIN Büşra
Published: August 2019

Giriş: Rekürren aftöz stomatit (RAS), günümüzde etyolojisi halen aydınlatılamamış hastalıklar arasındadır ve çoğunlukla sağlıklı kişilerde ortaya çıkar. Lokal ve sistemik koşullar ile genetik, immünolojik ve mikrobial faktörlerin patogenezde rol oynadığı düşünülmektedir. Oral aftlar; Behçet hastalığı , Reiter sendromu, rekürren eritema multiforme, Çölyak hastalığı, inflamatuar barsak hastalıkları, kollajen doku hastalıkları, AIDS, periyodik ateş, farenjit ve adenit (PFAPA) sendromu) gibi bazı sistemik hastalıklarıla birlikte görülebilmektedir. Bu nedenle RAS tanısı koyulurken oral ülserasyonlarla seyreden hastalıkların ayırıcı tanısı yapılmalıdır. Öykü ve fizik muayene sonrası, tam kan sayımı, B12, demir, folik asit yetersizliğinin değerlendirilmesi için testler istenmeli, replasman gereken durumlar saptanmalıdır.  Materyal ve metot: Dermatoloji polikliniğimize başvuran, RAS ayırıcı tanısı yapılıp buna neden olan herhangi bir sistemik hastalık tanısı almayan hastaların kan sayımı, sedimantasyon (sed), C-reaktif protein (CRP), serum demiri (SD), demir bağlama kapasitesi (DBK), vitamin B12, folik asit, vitamin D ve HBsAg, anti HCV, anti HIV tetkiklerinin sonuçları kayıtlardan incelenerek cinsiyetlere göre karşılaştırmalı olarak değerlendirildi. Bulgular: Kırk beş hastanın laboratuvar bulgularının incelendiği çalışmada hastaların yaş ortalaması 33,9 (11-66) idi. Hastaların 23’ü kadın, 22’si erkeklerden oluşmaktaydı. Cinsiyetler arasında yaş ortalamaları benzerdi, kadınlarda 36, erkeklerde 30. Hemoglobin düzeyleri kadınlarda erkeklere göre anlamlı olarak düşüktü (p=,000). Serum demiri ve demir bağlama kapasitesi ölçümleri de kadınlarda erkeklere göre  anlamlı düzeyde düşük bulundu (p=,000).  Vitamin B12, folik asit,, vitamin D düzeyleri ve CRP düzeyleri kadınlar ve erkekler arasında benzer düzeylerde ve D vitamini düzeyi dışında referans aralıklar içindeydi. Sonuç: RAS tanısı koyulan hastalarda, D vitamini düzeyleri cinsiyet fark etmeksizin tümünde referans değerin altında saptanmıştır. Daha geniş çaplı kontrollü çalışmalarla D vitamini düzeyinin etyopatogenezdeki rolünün incelemeye değer olduğunu düşünmekteyiz.
Aile Hekimi ve Pediatristlerin Geleneksel ve Tamamlayıcı Tıbba (GETAT) Bakışı
Authors: ORHAN Mehmet Fatih , ELMAS Bahri , ALTINDİŞ Selma , KARAGÖZ Rıdvan , ALTINDİŞ Mustafa
Published: August 2019

Amaç: Son yıllarda ülkemizde ve tüm dünyada isimlendirilmesinde hâlâ fikir birliği sağlanmamış olan, bir dizi geleneksel, tamamlayıcı tıp uygulamaları hekimler/hekim dışı kişilerce uygulanır hale gelmiştir. Hekimlerin bu gelişmelere bakışı merak edilmekte ve hastaların GETAT ile ilgili uygulamalar konusunda soruları olmaktadır. Biz de hedef grup olarak Pediatrist ve Aile Hekimlerinin GETAT Uygulamalarına Bakışı, Yaklaşımı ve Bilgi Düzeylerini ölçmeyi amaçladık. Yöntem: Tanımlayıcı nitelikteki bu çalışma; Nisan-Haziran 2019 aylarında Aile Hekimleri ve Pediatristler ile Google online anket aracılığıyla yapılmıştır. Veri toplama aracı olarak; gerekli literatür taraması sonucunda oluşturulan 33 soru katılımcılara online olarak yöneltilmiştir.Bulgular: Çalışmaya 106 kişi katıldı. Katılımcıların %69’u Aile Hekimi, %31’i pediatrist idi. Aile hekimlerinin GETAT sertifikası sahip olma oranı pediatristlere göre anlamlı derecede yüksekti. Bu uygulamaları hekimlerin %47’si hastalarına önerebileceklerini ifade ederken, %22’si önermeyeceğini söyledi, geri kalanı (%31) kararsızdı. Pediatristler, aile hekimlerine göre GETAT uygulamalarını daha az tavsiye ediyordu. Hekimler; %51 oranda GETAT yöntemlerini faydalı bulurken, %18’i faydasız buldu. GETAT konusunda bilgi düzeyi sorgulandı. Hiç yok %7, Az %54, Orta %28, İyi %8, Çok iyi %3 idi. “GETAT uygulamlarının koruyucu hekimliklik uygulamaları açısından olumlu etkilerinin olup olmayacağını” sorduğumuzda %48’i olumlu katkı sunacağını düşünüyordu. Sonuç: GETAT konusunda bilgi düzeylerinin iki büyük hekim grubu olan Aile Hekimleri ve Pediatrilerde yeterli düzeyde olmadığı, eğitimin hiçbir aşamasında geleneksel ve tamamlayıcı tıp ile ilgili bir eğitim almamakla birlikte Türk toplumunun bunu pratikte kullanıyor olması bu konuda bilimsel çalışmalar yapmayı ve bilgi sahibi olmayı zorunlu kılmakta, tutum ve davranışların daha doğru alınması sonucunu doğuracaktır.
Dural Sinus Trombozu İle Seyreden Pediatrik Adenoviral Meningoensefalit Vakası
Authors: ELMAS Bahri , GENÇ Gökçe , DAŞTAN Taha Mansur
Published: August 2019

Adenovirüs çocuklarda farklı birçok klinik tabloya neden olan bir DNA virüsüdür. Adenoviral menengioensefalit nadir görülen bir klinik tablodur. Ateş, ishal ve
konvülziyon nedeniyle çocuk acil servisimize başvuran 5,5 aylık kız hastanın BOS PCR incelemesinde adenovirüs saptandı. Kranial MR görüntülemesinde sentrum
semiovale, oksipital lob tutulumu ve dural sinüs trombozu saptandı. Hastaya antikoagülan tedavi uygulandı. Bu olgu nedeni ile adenovirüs meningoensefalitine dural sinüs
trombozunun da eşlik edebileceği unutulmamalıdır.
Perencanaan dan Penentuan Jadwal Induk Produksi di PT. Arwina Triguna Sejahtera
Authors: Sutoni Akhmad , Siddiq Muhammad Nasir
Published: August 2019

P.T. Arwina Triguna Sejahtera is a company engaged in the production of molding. Common issues in each company include P.T. Arwina Triguna Sejahtera, is experiencing constraints in planning the production amount according to production capacity. So planned to be created master production schedule so that the cost is not too high. Steps that are done is to start by doing data processing of the past by using demand aggregation, then do the forecasting in accordance with the characteristics of demand. Aggregate procurement planning is carried out for the next 1 (years) period using a permanent employment strategy. Then proceed at the disaggregation stage by using the proportion method, calculating the Master Production Schedule to find out how much quantity of product to produce, and when to start the production. Finally perform the calculation of Rought Cut Capacity Planning to know the balance between the available capacity and the required capacity. Production master schedule obtained, production will be smooth and able to meet the actual demand of 20,000 pcs by adding overtime hours and produce end items as much as 2.368 pcs for deabetamil scoop products, while for featherlock brown plastic products actual demand can be fulfilled. The feasibility of the master production schedule is calculated based on the suitability between Regular Man Hour on production plans, with the amount of time available in the calculated capacity capacity of 17,1360 hours to meet the demand for this year. Keywords—  Production Controlling and Planning; Master Production Schedule; Agregate Production Planning; Rought Cut Capacity Planning;  Production System.