bluuebunny/crossref_metadata_2025 huggingface dataset:
BASIC PRINCIPLES OF THE CONCEPT OF SUSTAINABLE DEVELOPMENT OF ECONOMIC ACTIVITY OF ENTERPRISE
Authors:   SHEE «Donetsk National Technical University», Volkova Yuliia
Published: April 2022

Today, Ukraine is undergoing a complex process of reforming socio-economic systems towards the development of a successful country. However, modern realities do not always meet economic requirements and provide opportunities to accelerate this pace. Therefore, a fundamentally new model of economic development in the context of globalization is needed. The introduction of the concept of sustainable development will allow for fundamental transformations in all spheres of society. After all, sustainable development is the new paradigm that will change the attitude to the environmental consciousness of enterprises. It should be noted that the concept of sustainable development provides for innovative and efficient use of natural resources, which will ensure a decent standard of living not only for present but also for future generations. Sustainable development provides updated guidelines for combining the three main components of the concept in the enterprise. Their balanced complex at the enterprise will help to increase the level of competitiveness of this enterprise. Therefore, as is already clear, it is necessary to implement the principles of sustainable development in the enterprise. It should be noted that the study of the concept of sustainable development, clarifying the basic components of the concept of sustainable development, the implementation of the principles of sustainable development in the enterprise is a very important topic for scientists. However, in general, scholars focus more on the above issues at the global and national economies. Nevertheless, scientists are engaged in questions of sustainable development at the enterprise. Insufficient study of the basic principles of sustainable development of economic activity of enterprises and contributed to this study. The article points to the need to introduce sustainable development in the enterprise, the positive aspects of implementing the concept of sustainable development in the enterprise. The study examines the basic principles of sustainable development of economic activity of the enterprise. After all, the implementation of the principles and conduct of economic activity based on sustainability will help the company to build a new model of strategic development.
RESEARCH OF METHODS OF MAKING MANAGEMENT DECISIONS AND RISKS ACCOMPANYING THEM
Authors:   National Technical University of Ukraine  «Igor Sikorsky Kyiv Polytechnic Institute», Zhluktenko Anna , Savchuk Oleksandra ,   National Technical University of Ukraine  «Igor Sikorsky Kyiv Polytechnic Institute», Lobodzynska Tetiana ,   National Technical University of Ukraine  «Igor Sikorsky Kyiv Polytechnic Institute»
Published: April 2022

Management has a broad meaning, which includes management, leadership, administration. And not only the state, the enterprise, the organization, but also first of all the personnel, that is people. We attach this meaning to this word in the modern world, although the principle of management has historically originated in ancient times, because people have long sought to create management structures for various activities and management of society. Therefore, management - resource management using methods of planning, organization, coordination, motivation, control and analysis of these resources to achieve this goal. Today, management is one of the main foundations of entrepreneurial activity, as it allows you to make the right decision to achieve the main goal of each organization - to increase the company's overall profits and reach the international level. The problem of making management decisions for a long period of time attracts the attention of scientists and managers at various levels. One of the indicators of a manager's activity is his ability to make the right decisions. Since managers perform four management functions, they actually deal with a constant flow of decisions for each of them, ie planning, organization, motivation and control. Development and decision-making is a creative process in the activities of managers. As such, there is no universal, unified approach. The method should be chosen based on the current situation and taking into account the available resources and other important points. Decision-making is an integral part of human activity in any field: political, economic, cultural, personal life, etc. Decision-making is a function of each person in personal life and a function of a leader of any level in the management process. The possible consequences of decisions can affect the interests of not only one person or several, but also large teams, regions and society as a whole. Managers usually make a number of different decisions (both operational and strategic) on which the future of companies depends. Decision-making is a matter of great responsibility both to the organization itself and to its employees and other stakeholders. Any production or commercial activity is always associated with the risk of loss. To do this, the specialist must anticipate possible risks, calculate the probable losses and compare them with the amount of planned profit. The purpose of the study is to study and analyze methods of management decisions and risks that may arise as a result of actions taken. The article considers the main methods and models of management decision-making used to ensure effective management decisions in conditions of risk and uncertainty.
PECULIARITIES OF ANTI-CRISIS MANAGEMENT OF THE ENTERPRISE OF THE HOTEL INDUSTRY IN THE CONTEXT OF THE SPREAD OF THE GLOBAL PANDEMIC
Authors:   Hetman Petro Sahaidachnyi National Army Academy, Ilchuk Olena , Udud Ivanna ,   Ivan Franko National University of Lviv, Ivantsiv Oksana ,   Ivan Franko National University of Lviv
Published: April 2022

The article is devoted the main aspects of the hotel industry, and proposes measures to form an integrated model of crisis management of the hotel. An analysis of data on Internet activity and promotion in social networks, which shows that a large number of global hotel chains continue to communicate with their followers, thus supporting their own brand. The article also research the current state implementation of anti-crisis measures during forced restrictions. It was found that many hotels use a variety of options to change their corporate strategies, including: simplification of procedures and focus on additional services; providing discounts and special offers if guests re-check into the hotel; creation of various loyalty programs, including the provision of corporate cards with a conical storage system or discounts; mitigation of cancellation conditions with possible cancellation of penalties, etc. However, according to statistics, all these measures become ineffective if there is no preliminary analysis of the factors that constrain the activities of the enterprise. Since the crisis management of hotel and restaurant enterprises is aimed at preventing and overcoming crises in the enterprise, as well as minimizing their negative consequences, when implementing or changing certain aspects of the crisis management strategy should take into account the time factor. The integrated model of anti-crisis hotel management which where proposed in the article decide reducing the consequences of the crisis and preventing its occurrence. This model has two main objectives: provide tools to improve the quality of guest service and employee motivation; development of a crisis management model that serves as a tool to improve long-term business relationships with other external counterparties and the state. The integrated model of crisis management for the hotel indystry, should be understood that this process is not a situational, forced measure, but a continuous process of the main activity; all measures within the crisis management should be implemented in the organizational culture of the hotel; department heads should play a key role in implementing this model.
La gestión de la oferta de agua: el caso de la zona metropolitana de Guadalajara
Authors:   Universidad de Guadalajara, Torres Rodriguez Alicia , Moran Martínez Francisco ,   Universidad de Guadalajara
Published: April 2022

This document analyzes some strategies based on the Supply Management Model for the supply of drinking water to the Guadalajara Metropolitan Area. To do this, the behavior of variables related to policies focused on supply management is examined, such as the design of projects and construction of hydraulic infrastructure by official institutions and based on the investments made, an analysis method is established to determine the impact of the sunken cost generated as a result of not making use of the infrastructure works already built. As part of the water management model based on demand, some strategies for the efficient use of this resource are integrated, through alternatives of water-saving technologies to be implemented in the field of domestic use.It is concluded that water management models historically in Mexico and particularly in the Guadalajara Metropolitan Area (zmg) have been using water resources associated with supply policies where the institutional argument has been based on the fact that to satisfy the growing demand for water due to the constant population growth, the construction of new supply sources is essential, without taking into account other alternative solutions.
Recreación del mundo interpersonal fantástico: traducción de los antropónimos en Viaje al Oeste
Authors:   Universidad de Nankai, Mi Tian , Muñoz Cabrera Rodrigo ,   Universidad de Nankai
Published: April 2022

La onomástica no sólo constituye un fenómeno lin-güístico particular de una lengua, sino que también alberga códigos extralingüísticos de muy diversa índole. En este artículo, desde un punto de vista lingüístico y comparativo, analizamos la traslación de los antropónimos chinos al español mediante el corpus paralelo de una de las novelas más clásicas de China, Viaje al Oeste, y sus dos traducciones en español. Hemos clasificado los 661 antropónimos de la novela según su carga semántica, semiótica o fono-lógica y detectado cuatro técnicas traductológicas en esta transferencia: la transcripción fonológica (con o sin notas explícitas e implícitas), la traducción, la creación y la omisión. Nuestro propósito es concluir y comparar los mejores métodos de traslación al tratar de transferir los antropónimos (sean reales o creados con fines literarios) del chino al español, hecho que requiere una investigación detallada a medida que se profundiza la comunicación entre estas dos culturas.
Crecimiento verde y digitalización de la economía: CJ Group como paradigma de desarrollo sostenible a la coreana
Authors:   Universidad Central de Chile, González Lustig Bernardita María , Véliz Portuguez Rodrigo Enrique ,   Universidad Central de Chile, Reyes Benz Arlette ,   Universidad Central de Chile
Published: April 2022

A mediados de 2020, Corea del Sur implementó la política llamada Korean New Deal (K-New Deal), que junto con enfrentar las consecuencias sociales negativas de la pandemia de la Covid-19, busca posicionar al país como líder en materias de crecimiento verde y digitalización de la economía. Esta política públi-ca proyectada en cinco años se asemeja a los planes quinquenales, donde el Estado desarrollista definía el curso que debían tomar los conglomerados de empresas surcoreanas (chaebol) en la economía. Aplicando un enfoque mixto de alcance descriptivo a través del método de estudio de caso, mediante una metodología de investigación de tipo documental, utilizando diversas fuentes bibliográficas —incluyen-do análisis de medios—, en este artículo se analiza el desarrollo sostenible en Corea del Sur aplicado a uno de los conglomerados económicos más importantes, denominado CJ Group (siglas de Cheil Jedang). La investigación permite concluir que el K-New Deal, como ejemplo de implementación de políticas de desarrollo sostenible, se perfilaría como un posible modelo a seguir en el contexto del crecimiento verde y la economía digital en la era post-Covid-19.
Competitividad: reto interconectado Empresa-País
Authors: Pacheco Ornelas Maria Cristina
Published: April 2022

Las nuevas economías de apertura creciente en materia de comercio internacional han suscitado el reto en las empresas para que desarrollen ventajas competitivas ante la hipercompetencia global. En este trabajo se exponen algunos modelos teóricos en que han sido propuestos distintos factores determinantes de ventajas competitivas para las empresas. Además se presenta el enfoque holístico, que enmarca el sistema de competitividad para el desarrollo de ventajas competitivas sustentables. El análisis de los distintos modelos da una visión de que la ventaja competitiva se sustenta en factores multidimensionales que deben gestarse dentro de las empresas y propugnarse con el apoyo de políticas públicas integrales y coherentes, puesto que de las ventajas competitivas de las empresas depende la consecuencia de la competitividad del país, lo cual representa un reto interconectado entre empresa-país.
La Ecoetiqueta en las pymes como una ventaja competitiva
Authors: Palos Delgadillo Humberto
Published: April 2022

la globalización por la que transitan las empresas las ha colocado en un ámbito de competencia donde es necesario conocer cómo y en qué sentido influyen los productos que lanzan al mercado y la incidencia ambiental que representan por los envases que generan. en este sentido, el presente trabajo aborda la problemática ambiental que representa este tipo de residuos poco atendidos en muchos países, y México no es la excepción, por lo que esta investigación está referida al uso de la etiqueta ecológica y su significación en cuanto a ser una ventaja competitiva en las pequeñas y medianas empresas. al respecto, se seleccionó una empresa fabricante de pinturas ubicada en la Zona Metropolitana de Guadalajara, la cual es precisamente generadora de residuos de envases, para que, mediante el estudio de caso, se pueda conocer el aspecto fenomenológico y proponerse el uso del eco etiquetado en los productos que se lanzan al mercado, para convertir esta problemática en un área de oportunidad cuya estrategia medioambiental garantice la atención a este problema y sea sinónimo de armonía con el medio ambiente.
PENGARUH PERENCANAAN DAN IMPLEMENTASI TERHADAP REALISASI ANGGARAN DENGAN KEBIJAKAN PERUBAHAN ANGGARAN SEBAGAI VARIABEL INTERVENING PADA DINAS KESEHATAN KOTA KUPANG
Authors: Mbado Margarethy Rohanie , Mbate Maromi Merlin
Published: April 2022

The Kupang City Health Office is an accounting entity from the Kupang City Government which is obliged to carry out accounting and accountability reports for the implementation of the Regional Revenue and Expenditure Budget by compiling financial reports in the form of Budget Realization Reports (LRA), Balance Sheets, and Notes to Financial Statements abbreviated as CALK. This type of research is quantitative using the SEM-PLS analysis tool. The informants in this study were employees who work in the Health Department of Kupang City.

The results showed that The results of the descriptive analysis of all the variables in this research were in the good category, so that the management of the Health Department needed to maintain the system that was already running and they needed to improve their work performance so that in the future it could be even better, Planning variable significantly influence with the budget policies variable of the Health Department of Kupang City, The planning variable does not significantly influence the budget realization variable, The implementation variable has a significant influence with the budget policies variable, The implementation variable does not significantly influence the budget realization variable, Budget policies variable significantly influence budget realization variable, Budget planning variable indirectly through budget policies has a significant influence on budget realization, Budget implementation variable indirectly through the budget policies significantly influence the budget realization.

Based on the results of this research, it is suggested that in running the plan, the Health Department of Kupang City should use achievement data as the estimate and the budget in planning needs to be increased, in the budget implementation of Health Department of Kupang City it is important to pay attention about coordination in the inclusion of APBD draft documents so that budget discipline can run properly, related to the budget realization of the Health Department of Kupang City, it should pay more attention to activities that involve many people
Erdheim-Chester disease: look it in the eye. An orbital magnetic resonance imaging study
Authors: Haroche Julien , Gueniche Yoram , Galanaud Damien , Cohen-Aubart Fleur , Dormont Didier , Rousseau Théophile , Amoura Zahir , Touitou Valerie , Shor Natalia
Published: April 2022

Erdheim-Chester disease (ECD) is a rare L-group histiocytosis. Orbital involvement is found in a third of cases, but few data are available concerning the radiological features of ECD-related orbital disease (ECD-ROD). Our aim was to characterize the initial radiological phenotype and outcome of patients with ECD-ROD. Initial and follow-up orbital magnetic resonance imaging (MRI) from the patients with histologically proven ECD at a national reference center were reviewed. Pathological orbital findings were recorded for 45 (33%) of the 137 patients included, with bilateral involvement in 38/45 (84%) cases. The mean age (± standard deviation) of these patients was 60 (±11.3) years and 78% were men. Intraconal fat infiltration around the optic nerve sheath adjacent to the eye globe (52%), with intense gadolinium uptake and a fibrous component was the most frequent phenotype described. Optic nerve signal abnormalities were observed in 47% of cases. Two patients had bilateral homogeneous extraocular muscle enlargement suggestive of a myositis-like involvement of ECD-ROD. None had isolated dacryoadenitis but in 17 eyes dacryodenitis was described in association with other types of orbital lesions. Only seven patients (15%) had normal brain MRI findings. ECD-associated paranasal sinus involvement and post-pituitary involvement were detected in 56% and 53% of patients, respectively. A decrease/disappearance of the lesions was observed in 17/24 (71%) of the patients undergoing late (>12 months) followups. Interestingly, ECD-ROD only rarely (7/45; 16%) revealed the disease, with exophthalmos being the most frequently identified feature in this subgroup (3/45; 6%). Even though ECD-ROD can be clinically silent, it comprises a broad array of lesions often resulting in optic nerve signal abnormalities, the functional outcome of which remains to be established. ECD-ROD should thus be assessed initially and subsequently monitored by orbital MRI and ophthalmological follow-up.
DIGITAL TECHNOLOGIES OF SUPPORT THE SPIRITUAL DEVELOPMENT OF STUDENTS
Authors: Lappo Violetta V. , Soichuk Ruslana L. , Akimova Liudmyla M.
Published: April 2022

The article deals with the problem of finding new means of spiritual values of university students. An attempt was made to prove that information and communication technologies can be involved in the educational process, not only as educational supply, but also as a means of spiritual education. It is noted that the humanization of the educational process becomes practical in the case of specially organized communication, which is created by teachers at lectures, seminars, workshops, academic competitions, scientific and practical conferences, exhibitions of creative works, thematic days, etc. It is noted that students should be formed with interest to information and communication technologies that contain information capable to enrich the spiritual world of the individual. The leading role in the mentioned process is given to the tutor of a student group. Among the internet technologies that have significant educational influence, there should be pointed out digital libraries, virtual museums and the Internet versions of educational channels, social networks and websites of educational institutions which are focused on activating different forms and methods of interaction between teachers and students, resulting in the formation and development of leading personality traits that constitute spiritual originality and affirm the moral imperative of the individual. Forms characterization of process organization of inculcating spiritual values on the main features is presented. It is found that the development of the spiritual value quintessence of future specialists should be organized in three spheres: mastering knowledge of spiritual, moral, aesthetic things; self-knowledge and self-improvement; participation in socially significant activities. The authors emphasize that the effectiveness of the information and communication technologies usage is possible in the case of the compliance with a number of educational conditions and confirms that for the formation of spiritual students' values a coherent educational system is needed to be created.
ЗАБЕЗПЕЧЕННЯ НАДІЙНОСТІ ПРОЦЕДУР ОЦІНЮВАННЯ ЗДОБУВАЧІВ В УМОВАХ ОНЛАЙН НАВЧАННЯ
Authors: Паккі Маріанна Сергіївна
Published: April 2022

На підставі здійсненого автором аналізу наукового доробку встановлено, що дослідники основними проблемами онлайн оцінювання вважають високий рівень академічної недоброчесності здобувачів (списування та колективну роботу над завданнями), а також складність перевірки в дистанційному режимі досягнутих ними результатів навчання та сформованих компетентностей. На користь цих тверджень свідчить і проведене автором статті опитування науково-педагогічних працівників. Задля вирішення вказаних проблем у статті розглянуто підхід до забезпечення надійності процедур онлайн оцінювання здобувачів, який передбачає методичну та організаційну складові. У межах даного підходу автор пропонує на етапі розробки процедур оцінювання сконцентруватися на підборі тих типів питань, за рахунок яких вдасться унеможливити академічну недоброчесність здобувачів та різнобічно перевірити їх підготовку. У статті дана характеристика низькопорядкових «загальноприйнятих (conventional)» та «концептуальних (conceptual)» типів питань. Розглянуто особливості питань «на впізнавання», «на пригадування», а також «на інтеграцію та використання». Сформульовано рекомендації щодо використання різних типів питань під час онлайн оцінювання здобувачів відповідно до рівнів таксономії Блума. Зокрема для оцінювання найвищих рівнів запропоновано використовувати кейси та ситуаційні задачі. Проведене опитування показало високий рівень залучення викладачів до процедур оцінювання в умовах онлайн навчання, що зменшує їх переваги в порівнянні з очним контролем. Тому серед організаційних засад проведення онлайн контролю автор пропонує обирати інструменти для оцінювання, які дають змогу використовувати автоматизовану перевірку навіть для завдань з «високопорядковими» типами питань. Наголошено на потребі завчасного ознайомлення здобувачів з процедурою онлайн оцінювання, наданню переваги підходу «low-stakes assessment». Також у статті описано досвід автора з використання гугл-форм та платформи «Online Test Pad».
Resistencia al aplastamiento en madera de Populus x canadensis ‘Conti 12’ para uniones tipo clavija, en dirección paralela y en dirección perpendicular a las fibras
Authors: Bassotti Ricardo Daniel , Balastegui Cristian , Cortizo Nicolás , Bay Cristian
Published: April 2022

En este estudio se presentan los resultados obtenidos de ensayos para determinar la resistencia al aplastamiento en uniones tipo clavija, en dirección paralela y en dirección perpendicular a las fibras, de la especie forestal Populus x canadensis ‘Conti 12’. Los ensayos se realizaron según las especificaciones establecidas en la Norma UNE-EN 383:2007 utilizando pernos de diámetros 5, 6, 7, 8, 10 y 12 mm. Se determinaron las tensiones de aplastamiento en ambas direcciones, resultando en dirección paralela a las fibras mayores que las obtenidas en dirección perpendicular a las fibras. En ambos casos los valores de la resistencia disminuyen a medida que aumenta el diámetro del pasador. El valor medio de la resistencia al aplastamiento para todas las muestras ensayadas en dirección paralela a las fibras resultó de 25,8 N/mm2 y el valor del percentil 5% de 19,9 N/mm2. En dirección perpendicular a las fibras el valor medio resultó de 17,4 N/mm2 y el valor del percentil 5% de 10,6 N/mm2. El valor medio de la densidad corregida a un contenido de humedad del 12% resultó de 406 kg/m3. Se compararon los valores de resistencia con los incluidos en el Suplemento 4 del Reglamento Argentino de Estructuras de Madera CIRSOC 601 y resultaron entre un 40% y un 67% menores, dependiendo de la dirección de aplicación de la carga en relación a la fibra y los diámetros de los pasadores.
EVALUATION OF THE RELATIONSHIP BETWEEN NURSING STUDENTS’ DYSFUNCTIONAL ATTITUDES AND THEIR ACCEPTANCE OF AESTHETIC SURGERY
Authors: İŞERİ Özge , ŞEN ATASAYAR Belgin
Published: April 2022

Abstract: The purpose of this study was to analyze the relationship between nursing students’ dysfunctional attitudes and their acceptance of aesthetic surgery. The study was performed as a descriptive study with 105 second-year nursing students at a health sciences faculty located in the central Black Sea Region of Turkey. The Descriptive Characteristics Form, the Acceptance of Cosmetic Surgery and the short-form Dysfunctional Attitudes Scale were used for the collection the data. Data were analysed by using the SPSS Statistics 23.0. Descriptive statistics (frequency, percentage, mean, and standard deviation), Mann-Whitney U, Kolmogorov-Smirnov, Kruskal-Wallis and Pearson's correlation tests were used. It was found that the mean of scores obtained from the Acceptance of Cosmetic Surgery Scale and the short-form Dysfunctional Attitudes Scale were respectively 52.44±20.97 and 87.64±17.97 points. Moreover, it was ascertained that there was a statistically significant weak negative correlation between the students’ dysfunctional attitudes and whether they accepted the aesthetic surgery (r= -0.281, p< 0.01). The nursing students have dysfunctional attitudes and acceptance for aesthetic surgery were above the medium level. Increasing dysfunctional attitude negatively affects the acceptance of aesthetic surgery. In light of this result, it is considered that, for raising awareness about the students’ dysfunctional attitudes and improving them, it is important to support the students and it is necessary to inform them about the aesthetic surgery. Nurse educators should provide students with additional education to identify dysfunctional attitudes. For this reason, it is recommended to include course contents that provide information about aesthetic surgery and dysfunctional attitudes in the nursing curriculum.
TOWARD A SHIFT IN EXPECTATIONS AND VALUES: WHAT WE’VE LEARNED FROM COLLABORATIVE ACTION RESEARCH IN NORTHERN INDIGENOUS COMMUNITIES
Authors: Stagg Peterson Shelly , Horton Laura , Restoule Jean Paul
Published: April 2022

In this paper we propose that collaborative action research values, goals and practices have much in common with guiding principles for conducting research with educators and community members in First Nation, Inuit and Metis communities, as outlined in the Task Force on Aboriginal Languages and Cultures on Aboriginal Languages and Cultures’ (2005) document. We draw on experiences in the Northern Oral Language and Writing through Play Partnership project to make our case, and conclude by identifying needed shifts in expectations and values within the broader academic community for conducting educational research in Indigenous communities.
REFLECTIONS ON THE CO-CREATION OF A COURSE WIKI An Editorial
Authors: Hunter Bill
Published: April 2022

Following several years in administration, I returned to teaching in 2010. My university has a strong commitment to technology in teaching and I share that commitment, but I was rusty. It seemed to me that if I wanted to stretch (and I did), I needed to start making use of social media. After considering some alternatives (Hunter & Austin, 2015), I concluded that building a course wiki would challenge my skills and those of my students. A wiki would also make it possible to maintain focus on the course content, which was “principles of learning.” I had not taught in this area for 20 years and I quickly realized how dramatically the field had changed.
The Fellowship of the Wiki? OR, A Readers Response to Hogendoorn’s “There and Back Again”
Authors: Bahula Timothy F.
Published: April 2022

Having spent countless hours in my youth reading and re-reading J. R. R. Tolkien lore, it was hard for me to miss Adrian Hogendoorn’s appropriation of the subtitle of Tolkien’s most accessible work. Tolkien published The Hobbit in 1937 with the subtitle There and Back Again as a children’s adventure novel, detailing the quest of Bilbo Baggins, his 13 dwarfish companions, and the wizard, Gandalf. The quest to reclaim the kingdom and treasure of the Lonely Mountain begins and ends in Bilbo’s sleepy, but respectable hobbit-hole, Bag End. Although Bilbo eventually returns home to Bag End, his journey there and back again has profoundly changed him, and in more ways than just making him inordinately wealthy. According to Tolkien lore, Bilbo recorded his adventures for posterity in The Red Book of Westmarch, which became Tolkien’s source for The Hobbit. Likewise, Hogendoorn’s Principles of Learning (PoL) wiki contributions illuminate episodes of his learning journey. He makes the connections between moments of learning in courses and specific wiki entries in his wikiography. I am slightly envious of his use of the wiki and the wikiography as a capstone project for his MEd studies. This “off-label use” of the wikiography seems to be a brilliant means of further entrenching the learning of his program of studies.
ASSESSMENT OF FLOW CHARACTERISTICS ALONG THE HYDRAULIC PHYSICAL MODEL OF A DAM SPILLWAY
Authors: Manogaran Thiennieesh , Mohd Arif Zainol Mohd Remy Rozainy , A. Wahab Muhammad Khairi , Abdul Aziz Mohd Sharizal , Zahari Nazirul Mubin
Published: April 2022

Water flowing over a spillway has a very high kinetic energy because of the conversion of the entire potential energy to kinetic energy. This circumstance results in damage or significant erosion at the toes of the spillways, weir bed, and downstream of a river. To solve this problem, the water flow velocity must be minimised. Physical modelling was implemented to this conundrum in order to modify the current energy dissipating structure, the stilling basin, to enhance energy dissipation as much as achievable by downstream velocity reduction. Baffle blocks were adopted as the modification in this study because these are widely used to stabilize the jumps, shorten its length, and maximize energy dissipation. A selection of baffle arrangements was evaluated by positioning them in the stilling basin’s mid-span to identify the most effective outcome in minimizing downstream velocity. From the findings, it was clearly shown the arrangement of baffles blocks at the stilling basin impacts velocity reduction in various discharge cases. The formation of cross-waves was also assessed at the discharge channel at every discharge value with its relative distance from the sump and the width of the channel prior to the site. For discharge situations of 70.0 L/s and 100.0 L/s, modifications to the Type II stilling basin were recommended. Furthermore, constriction, expansion, or curvature should be avoided in chute spillways identical to the dam spillway to limit cross-wave generation and other unfavourable flow behaviours
EDITORIAL SCOPE – STRUCTURE AND MATERIAL EDITION
Authors: Kueh Ahmad Beng Hong
Published: April 2022

This first-ever Editorial Scope of the Journal of Civil Engineering, Science and Technology (JCEST) touches the scientometrics of one of the main civil engineering disciplines, structure and material, in the publication realm. This brief editorial piece highlights the emerging and highly investigated themes in the last 5 years by gathering information from the wealth of the freely accessible Scopus database. Also, the most researched and published areas of JCEST within this period from the perspective of popular keywords are assembled and presented. The overlapped terms of the widely researched topics from the two sources are then captured to show their common publication territories of attention. This exercise aims to offer a brief guide for authors to better plan and navigate their knowledge quest to fit the currently trailblazing research curiosity and interest
Face-to-Face and Digital Networking in Business
Authors: Sakib S M Nazmuz
Published: April 2022

According to the business world, despite its power, the digital network can never replace the face-to-face network. While digital networks claim to achieve similar goals, they are no substitute for the person-to-person interaction that individuals need to form more meaningful relationships with real-world entities. business entity with credibility, integrity, and loyalty, all of which are important characteristics. But digital networking is a powerful tool for establishing brand visibility and social capital.
In Vivo Evaluation of Cefuroxime Axetil-Loaded Bioadhesive Nanoparticles to Treat Haemophilus influenzae-Induced Otitis Media
Authors: Lin Hong , Jia Yizhen , Kong Xiaohan , Wang Shiting , Liu Xiangyou , Liu Yang , Deng Yang
Published: April 2022

Otitis media (OM) is a common disease in children. One of the most common pathogens causing OM is non-typeable Haemophilus influenzae (NTHi). NTHi in the middle ear can be successfully eradicated by a regimen of oral antibiotics sustained for 7–10 days (e.g., cefuroxime axetil 250 mg/day for patients aged 3 months to 2 years and 500 mg/day for patients ages ≥2 years). However, lack of compliance is relevant to treatment failure or early relapse. In order to overcome these challenges, we have developed antibiotics-loaded bioadhesive nanoparticles (BNPs) that can adhere to the epidermis of the middle ear after local administration and significantly prolong the release time of antibiotics in the middle ear. Compared with oral administration of CA, local delivery of free antibiotic cefuroxime axetil (CA), and CA loaded non-bioadhesive nanoparticles (CA/NNPs), BNPs loaded with cefuroxime axetil (CA/BNPs) showed significantly longer retention time in the middle ear, resulting in continuous release of the drug and higher therapeutic efficacy against OM with only a single dosage. CA concentrations were maintained above the minimum inhibitory concentration (MIC) for NTHi throughout 7 days’ treatment. NTHi OM in a mouse model was successfully eradicated without causing tissue toxicity. CA/BNPs minimize systemic drug exposure through local administration, as demonstrated by undetectable levels in the blood.
Sonic Hedgehog Signaling in Cerebellar Development and Cancer
Authors: Wang Wanchen , Shiraishi Ryo , Kawauchi Daisuke
Published: April 2022

The sonic hedgehog (SHH) pathway regulates the development of the central nervous system in vertebrates. Aberrant regulation of SHH signaling pathways often causes neurodevelopmental diseases and brain tumors. In the cerebellum, SHH secreted by Purkinje cells is a potent mitogen for granule cell progenitors, which are the most abundant cell type in the mature brain. While a reduction in SHH signaling induces cerebellar structural abnormalities, such as hypoplasia in various genetic disorders, the constitutive activation of SHH signaling often induces medulloblastoma (MB), one of the most common pediatric malignant brain tumors. Based on the existing literature on canonical and non-canonical SHH signaling pathways, emerging basic and clinical studies are exploring novel therapeutic approaches for MB by targeting SHH signaling at distinct molecular levels. In this review, we discuss the present consensus on SHH signaling mechanisms, their roles in cerebellar development and tumorigenesis, and the recent advances in clinical trials for MB.
Update on the Epigenomic Implication of Embryo Cryopreservation Methods Applied in Assisted Reproductive Technologies With Potential Long-Term Health Effects
Authors: Reyes Palomares Arturo , Rodriguez-Wallberg Kenny A.
Published: April 2022

Cryopreservation of embryos has become an efficient method in Assisted Reproductive Technologies (ART) and these methods are currently performed at nearly all fertility centers around the globe. Cryopreservation of supernumerary embryos has contributed to an increase in cumulative pregnancy rates and as a consequence, an increasing number of children are being born through these techniques worldwide. However, long-term follow-up studies of children born through ART are scarce, and concerns about the long-term health effects on individuals conceived through ART have been raised. The relevant genomic transformations that occur at the time cryopreservation is usually applied to embryos may have potential epigenetic risks. With advances in multi-omic single cell technologies, new ways to assess the (epi)genomic status during early embryo development have now become feasible. These novel strategies could provide a revolutionary opportunity to understand the actual impact of ART, but also may help future developments aiming at increase both their efficiency and safety. Here we outline insights in current knowledge and research on the impact of cryopreservation on embryos, the possible consequences at epigenetic level and how emerging new high-throughput technologies can be used for their assessment.
The Effects of Mechanical Stretch on Integrins and Filopodial-Associated Proteins in Normal and Glaucomatous Trabecular Meshwork Cells
Authors: Yang Yong-Feng , Sun Ying Ying , Peters Donna M. , Keller Kate E.
Published: April 2022

The trabecular meshwork (TM) is the tissue responsible for regulating aqueous humor fluid egress from the anterior eye. If drainage is impaired, intraocular pressure (IOP) becomes elevated, which is a primary risk factor for primary open angle glaucoma. TM cells sense elevated IOP via changes in their biomechanical environment. Filopodia cellular protrusions and integrin transmembrane proteins may play roles in detecting IOP elevation, yet this has not been studied in detail in the TM. Here, we investigate integrins and filopodial proteins, such as myosin-X (Myo10), in response to mechanical stretch, an in vitro technique that produces mechanical alterations mimicking elevated IOP. Pull-down assays showed Myo10 binding to α5 but not the β1 subunit, αvβ3, and αvβ5 integrins. Several of these integrins colocalized in nascent adhesions in the filopodial tip and shaft. Using conformation-specific antibodies, we found that β1 integrin, but not α5 or αvβ3 integrins, were activated following 1-h mechanical stretch. Cadherin -11 (CDH11), a cell adhesion molecule, did not bind to Myo10, but was associated with filopodia. Interestingly, CDH11 was downregulated on the TM cell surface following 1-h mechanical stretch. In glaucoma cells, CDH11 protein levels were increased. Finally, mechanical stretch caused a small, yet significant increase in Myo10 protein levels in glaucoma cells, but did not affect cellular communication of fluorescent vesicles via filopodia-like tunneling nanotubes. Together, these data suggest that TM cell adhesion proteins, β1 integrin and CDH11, have relatively rapid responses to mechanical stretch, which suggests a central role in sensing changes in IOP elevation in situ.
V(D)J Recombination: Recent Insights in Formation of the Recombinase Complex and Recruitment of DNA Repair Machinery
Authors: Christie Shaun M. , Fijen Carel , Rothenberg Eli
Published: April 2022

V(D)J recombination is an essential mechanism of the adaptive immune system, producing a diverse set of antigen receptors in developing lymphocytes via regulated double strand DNA break and subsequent repair. DNA cleavage is initiated by the recombinase complex, consisting of lymphocyte specific proteins RAG1 and RAG2, while the repair phase is completed by classical non-homologous end joining (NHEJ). Many of the individual steps of this process have been well described and new research has increased the scale to understand the mechanisms of initiation and intermediate stages of the pathway. In this review we discuss 1) the regulatory functions of RAGs, 2) recruitment of RAGs to the site of recombination and formation of a paired complex, 3) the transition from a post-cleavage complex containing RAGs and cleaved DNA ends to the NHEJ repair phase, and 4) the potential redundant roles of certain factors in repairing the break. Regulatory (non-core) domains of RAGs are not necessary for catalytic activity, but likely influence recruitment and stabilization through interaction with modified histones and conformational changes. To form long range paired complexes, recent studies have found evidence in support of large scale chromosomal contraction through various factors to utilize diverse gene segments. Following the paired cleavage event, four broken DNA ends must now make a regulated transition to the repair phase, which can be controlled by dynamic conformational changes and post-translational modification of the factors involved. Additionally, we examine the overlapping roles of certain NHEJ factors which allows for prevention of genomic instability due to incomplete repair in the absence of one, but are lethal in combined knockouts. To conclude, we focus on the importance of understanding the detail of these processes in regards to off-target recombination or deficiency-mediated clinical manifestations.
Oral Microbiota-Driven Cell Migration in Carcinogenesis and Metastasis
Authors: Bai Huimin , Yang Jing , Meng Shu , Liu Chengcheng
Published: April 2022

The oral cavity harbors approximately 1,000 microbial species, and both pathogenic and commensal strains are involved in the development of carcinogenesis by stimulating chronic inflammation, affecting cell proliferation, and inhibiting cell apoptosis. Moreover, some substances produced by oral bacteria can also act in a carcinogenic manner. The link between oral microbiota and chronic inflammation as well as cell proliferation has been well established. Recently, increasing evidence has indicated the association of the oral microbiota with cell migration, which is crucial in regulating devastating diseases such as cancer. For instance, increased cell migration induced the spread of highly malignant cancer cells. Due to advanced technologies, the mechanistic understanding of cell migration in carcinogenesis and cancer metastasis is undergoing rapid progress. Thus, this review addressed the complexities of cell migration in carcinogenesis and cancer metastasis. We also integrate recent findings on the molecular mechanisms by which the oral microbiota regulates cell migration, with emphasis on the effect of the oral microbiota on adhesion, polarization, and guidance. Finally, we also highlight critical techniques, such as intravital microscopy and superresolution microscopy, for studies in this field.
Zero Fluoroscopy Arrhythmias Catheter Ablation: A Trend Toward More Frequent Practice in a High-Volume Center
Authors: Troisi Federica , Guida Pietro , Quadrini Federico , Di Monaco Antonio , Vitulano Nicola , Caruso Rosa , Orfino Rocco , Cecere Giacomo , Anselmino Matteo , Grimaldi Massimo
Published: April 2022

Background

Awareness of radiation exposure risks associated to interventional cardiology procedures is growing. The availability of new technologies in electrophysiology laboratories has reduced fluoroscopy usage during arrhythmias ablations. The aim of this study was to describe procedures with and without X-Rays and to assess feasibility, safety, and short-term efficacy of zero fluoroscopy intervention in a high-volume center oriented to keep exposure to ionizing radiation as low as reasonably achievable.

Methods

Cardiac catheter ablations performed in our hospital since January 2017 to June 2021.

Results

A total of 1,853 procedures were performed with 1,957 arrhythmias treated. Rate of fluoroless procedures was 15.4% (285 interventions) with an increasing trend from 8.5% in 2017 to 22.9% of first semester 2021. The most frequent arrhythmia treated was atrial fibrillation (646; 3.6% fluoroless) followed by atrioventricular nodal reentrant tachycardia (644; 16.9% fluoroless), atrial flutter (215; 8.8% fluoroless), ventricular tachycardia (178; 17.4% fluoroless), premature ventricular contraction (162; 48.1% fluoroless), and accessory pathways (112; 31.3% fluoroless). Although characteristics of patients and operative details were heterogeneous among treated arrhythmias, use of fluoroscopy did not influence procedure duration. Moreover, feasibility and efficacy were 100% in fluoroless ablations while the rate of major complications was very low and no different with or without fluoroscopy (0.45 vs. 0.35%).

Conclusion

Limiting the use of X-Rays is necessary, especially when the available technologies allow a zero-use approach. A lower radiation exposure may be reached, reducing fluoroscopy usage whenever possible during cardiac ablation procedures with high safety, full feasibility, and efficacy.
Serum Chloride Is Inversely Associated With 3 Months Outcomes in Chinese Patients With Heart Failure, a Retrospective Cohort Study
Authors: Fu Zhiqing , An Li , Lu Xiaochun , Sheng Li , Liu Hongbin
Published: April 2022

Background

Serum chloride was recently found to be associated with prognosis of heart failure in western countries. However, the evidence was scarce in Asia. We aimed to investigated the relationship between serum chloride and clinical outcomes in a Chinese cohort with hospitalized heart failure.

Methods

We retrospectively analyzed the data from PhysioNet, involving 1996 patients who were admitted with heart failure between December 2016 and June 2019. Outcome was a composite endpoint of all-cause death or rehospitalization at 3 months.

Results

The incidence of the composite endpoint was 26.8% (535/1,996); it was 32.2% (213/662), 25.0% (165/661), and 23.3% (157/673) by chloride tertiles (from the lowest to the highest), respectively. The serum chloride at admission was independently and inversely associated with the composite endpoint risk (hazard ratio: 0.967; 95% confidence interval: 0.939 to 0.996; p = 0.026) in contrast to sodium, which was no longer significant (p > 0.05) after multivariable adjustment. Pearson correlation between serum chloride and sodium was 0.747 (p < 0.001). However, an increased AUC was not observed by adding sodium to model composed of age, sex, NYHA class, diabetes, log BNP and chloride (0.620 vs. 0.612, p = 0.132). Subgroup analysis showed the presence or absence of hyponatremia did not affect the association between chloride and composite endpoint risk.

Conclusions

Low serum chloride at admission was associated with poor outcomes in Chinese hospitalized patients with heart failure. These findings warrant future studies for tackling the potential pathophysiological mechanisms and correction methods of hypochloremia in heart failure.