bluuebunny/crossref_metadata_2025 huggingface dataset:
Improving the genistein oral bioavailability via its formulation into the metal–organic framework MIL-100(Fe)
Authors: Botet-Carreras Adrià , Tamames-Tabar Cristina , Salles Fabrice , Rojas Sara , Imbuluzqueta Edurne , Lana Hugo , Blanco-Prieto María José , Horcajada Patricia
Published: February 2021

Despite the interesting chemopreventive, antioxidant and antiangiogenic effects of the natural bioflavonoid genistein (GEN), its low aqueous solubility and bioavailability make it necessary to administer it using a suitable drug carrier system.
Ferroelastic domains and phase transitions in organic–inorganic hybrid perovskite CH3NH3PbBr3
Authors: Bari Maryam , Bokov Alexei A. , Ye Zuo-Guang
Published: February 2021

Polarized light microscopy reveals twin domains and symmetry of the phases in CH3NH3PbBr3 crystal; domain structure remains unresponsive to electric field but changes under external stress, confirming ferroelasticity while ruling out ferroelectricity.
Tris(4-(1-phenyl-1H-benzo[d]imidazole)phenyl)phosphine oxide for enhanced mobility and restricted traps in photovoltaic interlayers
Authors: Lim Jihyun , Choi Do-Yeong , Jang Woongsik , Choi Hyeon-Ho , Kim Yun-Hi , Wang Dong Hwan
Published: February 2021

Small molecule organic material, tris(4-(1-phenyl-1H-benzo[d]imidazole)phenyl)phosphine oxide (TIPO) was newly synthesised and introduced into an n-type interlayer in planar perovskite solar cells for effective electron transport.
A novel ruthenium polypyridyl complex for the selective imaging and photodynamic targeting of the Golgi apparatus
Authors: Zhao Fengyi , Wang Weifan , Wu Wenlong
Published: February 2021

An excellent example for the ruthenium(ii) complex to lable the Golgi apparatus in vitro with significant photodynamic therapy.
In situ immobilization of Fe/Fe3C/Fe2O3 hollow hetero-nanoparticles onto nitrogen-doped carbon nanotubes towards high-efficiency electrocatalytic oxygen reduction
Authors: Zhang Binbin , Li Tongfei , Huang Longzhen , Ren Yiping , Sun Dongmei , Pang Huan , Yang Jun , Xu Lin , Tang Yawen
Published: February 2021

We demonstrate a feasible synthesis of Fe/Fe3C/Fe2O3 hollow hetero-nanoparticles in situ immobilized on highly graphitic nitrogen-doped carbon nanotubes via a hydrogel-bridged pyrolysis strategy for excellent electrocatalytic oxygen reduction.
A multi-responsive organogel and colloid based on the self-assembly of a Ag(i)-azopyridine coordination polymer
Authors: Li Botian , Xiao Da , Gai Xiaodong , Yan Bo , Ye Haimu , Tang Liming , Zhou Qiong
Published: February 2021

A multi-responsive self-healable organogel and colloid were fabricated by the assembly of a coordination polymer derived from Ag(i) and azopyridine ligands.
Identification of immune-related lncRNAs to improve the prognosis prediction for patients with papillary thyroid cancer
Authors: Li Zhiyang , Lin Weixun , Zheng Jiehua , Hong Weida , Zou Juan , Zhang Taofeng , Chen Yexi , Lu Hai
Published: February 2021

Objective: To identify immune-related long non-coding RNAs (lncRNAs) in papillary thyroid cancer (PTC).

Methods: The Gene Expression Omnibus (GEO) and The Cancer Genome Atlas (TCGA) databases were used to obtain the gene expression profile. Immune-related lncRNAs were screened from the Molecular Signatures Database v4.0 (MsigDB). We performed a survival analysis of critical lncRNAs. Further, the function of prognostic lncRNAs was inferred using the Gene Ontology (GO) enrichment analysis and Kyoto Encyclopedia of Genes and Genomes (KEGG) to clarify the possible mechanisms underlying their predictive ability. The assessment was performed in clinical samples and PTC cells.

Results: We obtained 4 immune-related lncRNAs, 15 microRNAs (miRNAs), and 375 mRNAs as the key mediators in the pathophysiological processes of PTC from the GEO database. Further, Lasso regression analysis identified seven prognostic markers (LINC02550, SLC26A4-AS1, ACVR2B-AS1, AC005479.2, LINC02454, and AL136366.1), most of which were related to tumor development. The KEGG pathway enrichment analysis showed different, changed genes mainly enriched in the cancer-related pathways, PI3K-Akt signaling pathway, and focal adhesion. Only SLC26A4-AS1 had an intersection in the results of the two databases.

Conclusion: LncRNA SLC26A4-AS1, which is the most associated with prognosis, may play an oncogenic role in the development of PTC.
Development and Functionality of an Internet-Based, Self-Managed Parent Training Program
Authors: Morris Lekeitha R. , Bellon-Harn Monica L.
Published: February 2021

Purpose

This research note evaluated a self-managed, Internet intervention (i.e., Success With Stories) designed to facilitate parental reading practices and beliefs.

Method

Twelve reviewers were composed of parents of young children, speech-language pathologists, and experts in self-managed, Internet intervention. Satisfaction of usability, content, presentation, suitability, and exercises of Success With Stories was examined using an intervention satisfaction rating. Value and usefulness of content was evaluated via a survey.

Results

Reviewers found content to be valuable and useful for facilitating parental reading practices and beliefs. Results indicated high satisfaction across all reviewers.

Conclusion

Results point toward strengths and limitations of the protocol and future directions.
Multi‐level feature fusion network for crowd counting
Authors: Wang Luyang , Li Yun , Peng Sifan , Tang Xiao , Yin Baoqun
Published: February 2021

Crowd counting has become a noteworthy vision task due to the needs of numerous practical applications, but it remains challenging. State‐of‐the‐art methods generally estimate the density map of the crowd image with the high‐level semantic features of various deep convolutional networks. However, the absence of low‐level spatial information may result in counting errors in the local details of the density map. To this end, a novel framework named Multi‐level Feature Fusion Network (MFFN) for single image crowd counting is proposed. The proposed MFFN, which is constructed in an encoder–decoder fashion, incorporates semantic and spatial information for generating high‐resolution density maps of input crowd images. Skip connections are developed between the encoder and the decoder so that low‐level spatial information and high‐level semantic features can be combined by element‐wise addition. In addition, a dense dilated convolution block is placed behind the encoder, extracting multi‐scale context features to guide feature fusion by a channel attention mechanism. The model is trained by multi‐task learning; semantic segmentation supervision is introduced to enhance feature representation. Extensive experiments are conducted on three crowd counting datasets (ShanghaiTech, UCF_CC_50, UCF‐QNRF), and the results show that MFFN outperforms state‐of‐the‐art methods. In addition, sufficient ablation studies are performed to verify the effectiveness of each component in our proposed method.
Paper-based flexible metamaterial for microwave applications
Authors: Zhang Zidong , Zhao Yaman , Fan Guohua , Zhang Wenjin , Liu Yao , Liu Jiurong , Fan Runhua
Published: February 2021

Metamaterial has become a hotspot in many research fields, including electromagnetism, thermodynamics and mechanics, as it can offers additional design freedom for material to obtain novel properties. Especially for the electromagnetic devices, various interesting electromagnetic properties which cannot be found in nature materials can be realized, such as negative refraction, invisible cloak, etc. Herein, we provide an overview of paper-based metamaterial for microwave application. This work reviews the metamaterial realized on paper substrate, including the fabrication techniques, application fields, as well as the outlook on future directions of the paper-based metamaterial for the readership.
A miniaturized frequency selective rasorber with high selectivity passband and wideband absorption properties
Authors: Wu Yanjie , Xiong Jie , Deng Feng , Lin Hai , Wang You
Published: February 2021

A miniaturized frequency selective rasorber (FSR) with high selectivity passband and wideband absorption properties is presented. Its performance as an absorber over a wide absorption band from 8.08 to 18.08 GHz through the structure of metal incurved square loop structure loaded resistors. The frequency selective surface (FSS) using Jerusalem cross array and metallic patch realizes the transmission frequency band from 2.7 to 3.52 GHz. And the insertion loss (IL) is 0.37 dB at 3.08 GHz. The symmetry and miniaturized elements design enable the proposed FSR to achieve satisfactory incident angle stability. Its small unit size effectively avoids the generation of grating lobes in the absorption band and the interference to Radar Cross Section (RCS) reduction.
Design of Rehabilitation Training System for Pelvic Floor Dysfunction
Authors: Liu Yongfeng , Li Chunna , Zhong Jun , Cai Liming , Guo Kai
Published: February 2021

Pelvic floor dysfunction has caused pain to the lives of the majority of female patients, and repeated visits to the hospital for treatment have also caused inconvenience to patients. Therefore, a portable pelvic floor dysfunction rehabilitation training system is designed to help female patients with personalized and private treatment. The pelvic floor dysfunction rehabilitation system realizes the independent training mode selection through the APP client, assists the pelvic floor muscle rehabilitation training through the electrical stimulation module, and can realize the recovery situation of the pelvic floor muscle strength in real time through the AD acquisition module. The experimental results show that the pelvic floor dysfunction rehabilitation training system implements bipolar electrical stimulation pulses, and the EMG signals collected at the same time clearly show the EMG signal strength and strength maintenance time.
Research on Performance Evaluation of Diversified Government Quality Work and Analysis on Application Practice in Nei Mongol
Authors: Feng Lei , Huang Juxiu , Liao Jingxing
Published: February 2021

The evaluation of public satisfaction with government quality work is an evaluation form to evaluate government performance from the perspective of the public. The evaluation process is open and transparent, and the results are relatively objective and fair. Taking the application practice in Nei Mongol as an example, in this paper, an index framework is designed and constructed, 12 leagues and cities in the whole region are covered by the investigation, and the actual effect of local quality work is explored and analyzed in combination with big data technology so as to provide enlightenment and reference for relevant research work in the quality field.
Job Burnout and Its Relevant Factors among Medical Interns
Authors: Hou Yongmei , Fu Haojun
Published: February 2021

Objective: to understand the present situation of job burnout among medical interns and to explore its major influencing factors. Methods: A stratified random sampling was used to select 1268 medical interns from 6 full-time medical colleges in Guangdong province. They were investigated with Maslach Burnout Inventor-General Survey, (MBI–GS), Questionnaire on Humanistic Care Ability of Medical Students (QHCAMS) and a self-compiled personal information questionnaire. Results: (1) The incidence of job burnout in this group was 98.40%. The total score of MBI–GS and the scores of emotional exhaustion, cynicism and reduced personal accomplishment were (45.27 ±12.61), (16.21 ±4.91), (12.91 ±3.93) and (18.15 ±5.22), respectively. (2) The result of multiple stepwise linear regression showed that gender, specialty, type of internship hospital, working department and average length of overtime per day were positively correlated with the total score of MBI-GS (β =.154~.676, all P < 0.01). Nine factors, such as self-evaluation of health status, ability to solve problems at work, relationship with patients, classmates and medical staff, as well as the scores of hope, honesty, humility and courage in HQCAMS, were negatively correlated with the total score of MBI-GS (β =-.148~-.468, all P < 0.01). Conclusion: Medical interns are suffering serious job burnouts, which may be related to work pressure, personal quality and other factors.
A Study on Satisfaction of Elderly Care Service Quality Based on Different Groups: Taking the Monitoring Data of Liaoning Province as an Example
Authors: Liao Jingxing , Feng Lei , Huang Juxiu
Published: February 2021

The monitoring and analysis of the social public service quality is conducive to promoting the construction of a service-oriented government that the people are satisfied with. In this paper, the third-party quality monitoring is carried out in 14 cities in Liaoning Province from 11 public service areas, including residential environment, public transportation, infrastructure, medical and health care, public security, cultural and sports, compulsory education, elderly care service, employment service, social security and administrative convenience. The results show that the public's satisfaction with social security, compulsory education, residential environment, public security and employment service is low, which needs to be paid attention to and further improved by Liaoning provincial government.
Research on the Relationship between Psychological Safety and Individual Job Burnout
Authors: Qi Xueyang , Wen Yu
Published: February 2021

The development of globalization and the acceleration of informatization have made the competition between enterprises more and more fierce, and organizations must respond to new opportunities and challenges through organizational change. Organizational change also makes employees' working environment more and more complex, occupational uncertainties and risks are increasing, which in turn brings employees psychological insecurity and job burnout. In this paper, through combing the related research of psychological safety and job burnout, the negative relationship between psychological safety and individual job burnout is verified by empirical analysis, and according to the conclusion, relevant suggestions are proposed to the organization management, trying to help the organization take effective measures to satisfy employees' psychological safety needs and reduce the phenomenon of job burnout.
An Exploration into the Influence of Higher Vocational Students' Psychological Capital on Their Employability
Authors: Li Xiong , Zhang Qiaoling , Cao Yongzhong , Yang Jinping , Yang Mei
Published: February 2021

Cultivating higher vocational students' employability is one of the most important goals for higher vocational education. Many researchers address teachers' key roles in cultivation of employability. However, the cultivation of employability relates to students' family environment and psychological capital. Through the collection of demographic data, 6700 higher vocational students were investigated with the Positive Psychological Capital Questionnaire (PPQ) and the College Students' Employability Questionnaire (CSEQ). The results show that psychological capital is significantly correlated with employability (P < 0.01); although family environment can not regulate the impact of psychological capital on employability, it works independently as psychological capital does; the self-efficacy, optimism and hope in psychological capital significantly affect the employability of higher vocational students from single-parent families. The improvement of psychological capital is conducive to the cultivation of employability of higher vocational students from single-parent families.
Research on the Relationship between the Female Directors' Personal Characteristics and the Quality of Accounting Information
Authors: Yin Lu
Published: February 2021

This paper explores the relationship between female directors and the quality of accounting information. it takes 51 enterprises from 2008 to 2018 as samples, selects the proportion of female directors, age, education background and financial background to study the personal characteristics. The results show that: the percentage of female directors is directly proportional to the accounting information; the higher the female director's education, the higher the quality of information; the female directors with financial background have a specific positive effect on the improvement of accounting information. Based on this, this paper proposes some suggestions on how to strengthen the construction of the board of directors and improve the quality of information about listed companies.
Entrepreneurial Improvisation: Research Review, Integration Framework and Future Outlook
Authors: Xu Xuejiao , Zhao Yaqi , Zhang Jing
Published: February 2021

At present, the development context of entrepreneurial improvisation research is still unclear. This article reviews and sorts out the relevant literature on entrepreneurial improvisation from the individual and organizational levels: starting from the connotation, constituent elements and induction mechanism, classifies and sorts out the relevant research on entrepreneurial improvisation, and proposes an integrated framework and framework based on the summary of the frontier topics of entrepreneurial improvisation. The prospect of the future is expected to provide reference for the in-depth research and practice of entrepreneurial improvisation in the future.
Investor Sentiment Index and Option Price Volatility Based on MIDAS Model: Evidence from China
Authors: Xiao Haiyan , Hao Yingxin , Wu Sirong
Published: February 2021

The paper selects the transaction data of the option market and network data from June 1, 2015 to February 2, 2018. The principal component analysis is adopted to construct investor sentiment index. The OLS and MIDAS model are employed to study the influence of investor sentiment index on the option implied volatility in Shanghai Stock Exchange 50ETF. The empirical results show that the MIDAS model with more high-frequency information has stronger interpretation ability than the same frequency model. Investor sentiment index based on traditional indicators has a negative effect on the option implied volatility while the excessive attention of investors on the Internet would exert positive pressure on the option market. The conclusion can well explain the inherent mechanism of investor sentiment affecting option implied volatility. Therefore, it is of great practical significance to study the influence of investor sentiment on the option price volatility in China
Study on Post-editing for Machine Translation of Railway Engineering Texts
Authors: Li Yuting , Lu Xiuying
Published: February 2021

With rapid development of China's railways, there are more overseas construction projects and technical exchanges in the field of railway engineering, which have generated widespread demands for translation. To meet the increasingly growing demands for translation of railway engineering texts, the mode of machine translation plus post editing (MTPE) has been frequently applied besides traditional human translation (HT) for the combination of translation quality and efficiency. Through the case study of post editing in the machine translation of China's High-Speed Railway by Google Translate, this paper discusses the common error types of machine translation in railway engineering translation, and puts forward corresponding post editing strategies, so as to provide references for MTPE of railway engineering translation in the future. It is hoped that research on post editing in the mode of machine translation for railway engineering texts may improve the translation quality and efficiency, thus helping speed up the process of China's railway going global.
Technology of personnel training for the transport industry
Authors: Vinichenko Victoriya Alexandrovna
Published: February 2021

The paper is devoted to the study of modern educational technologies used to train specialists in the transportation industry. The prerequisites for updating and supplementing existing educational technologies are considered. Critical skills for various modes of transport are identified. The challenges of the global socio-economic architecture that dictate updated requirements to the educational environment are defined. A review of the world practice in training personnel for the transportation industry was carried out, and a comparative analysis of the technologies used in a number of countries was conducted. As a result, we have obtained a set of best practices used for training specialists in the field of transport. The comparative analysis shows that some practices are equally and successfully applied both in Russia and abroad. There are also specified some trends in the influence of processes occurring in transport on the further transformation of the industry’s human resources. The direction for future research has been determined.
Exhibition projects as a technology of educational activity of higher school
Authors: Zhelnina Z. Yu. , Tereshchenko E. Yu.
Published: February 2021

The educational technologies of higher education are changing in the context of the growing influence of creative industries, the priority of the values of over-professional competencies and the expansion of the range of tasks associated with the development of cultural processes in the territories. The article discusses ways of modifying exhibition activities, where proprietary technologies are rapidly developing, trends in digitalization and event practices are strong, including performances, happening, master classes. Universities are involved in creative practices, but such work requires pedagogical logic, a methodology for involving young people in this area. The purpose of the study was to search for reliable methods and resources necessary for a successful strategy for the development of the art space of the university. Analysis of training courses related to exhibition work, an overview of the sites available for the presentation of youth projects, student surveys on motivation in the field of creative initiatives have become methods of obtaining the initial research data. As a result, it is concluded that it is necessary to develop the art space of the university as an independent educational practice, including for the development of open massive online courses and the formation of art collections in the multimedia format.
Postgraduate “Management” program design for small and medium business managers
Authors: Mamontov Sergey
Published: February 2021

The paper suggests an approach to teaching and implementing research in the master’s degree studies, which are oriented at system training of heads/owners and managers of small and medium-sized businesses that do not have basic management education, but, as a rule, have a higher technical or technological education and sufficient practical experience. Hypothesis of the article is the assumption that the teaching specifics of this segment should be based on interdisciplinary coordination of content, organization of training, and communication. Verifying this hypothesis based on a review of the literature and identifying the specifics of the segment is the overall goal of the article. As a particular corollary we justify a special educational event (a cycle of research seminars) that integrates various components of training students in the master’s program, in the framework of project activities logic that corresponds to the logic of the modern production process. We show the difference between this segment and consumers who are focused on the MBA and MIM programs, and provide examples from Russian reality. Taking into account the consumer characteristics of the segment, we propose an organizational and pedagogical approach to the formation of key competencies in the field of management for students representing this segment. In particular, we argue for teaching students of this group in the frame of the master’s program, based on the project approach both in the content and in its organization. The article notes that the pedagogical features of the formation of project competencies in students of this segment dictate the use of the method of ascending from the abstract to the concrete as a basis for building a general learning strategy. Decomposition of the learning strategy and the master’s thesis research demonstrates the need for interdisciplinary coordination of content, training and organizing communication.
The project of professional career orientation complex for ASD pupils based on virtual reality technologies
Authors: Tokarskaia Ludmila V. , Bystrova Tatiana Y. , Valieva Elmira R.
Published: February 2021

The paper analyses the application of virtual reality technologies to career guidance of children and adolescents with autism spectrum disorders (ASD). An overview of studies using virtual reality technologies conducted with children and adolescents with ASD, including diagnosis and teaching of schoolchildren with autism spectrum disorders, is made. The authors follow “The Theory of Central Coherence” by U. Frith, realizing symptoms of autism spectrum disorders not as disorders but as peculiar features and a special cognitive style. The study describes the features of vocational guidance of ASD individuals on the basis of the sources about the difficulties of people with ASD in the transition from school to secondary and higher education. The authors’ project of a complex vocational guidance using virtual reality technology for students with ASD introducing “a city-farmer” profession is represented. The tripartite structure of the vocational guidance complex is showed, the need for interaction of specialists with the parents of a child with ASD, as well as identification of “savant skills” at the first stage of career guidance work was emphasized. Examples of virtual spaces developed by one of the authors are given, with which people with ASD interact by the determination their possible professional trajectory. The tasks and responses of users in the vocational guidance complex for schoolchildren are described. A conclusion about the possibility of expanding the list of professions in the vocational guidance simulator for children with ASD is made.
The development of preschoolers’ financial literacy in the cooperation of the kindergarten and the family
Authors: Belinova Natalia Vladimirovna , Bicheva Irina Borisovna , Krasilnikova Larisa Vladimirovna , Khanova Tatiana Gennadievna , Vyalova Natalya Vyacheslavovna , Zhanna  , Baskaeva Khasanbekovna
Published: February 2021

The article introduces the study of the development of preschoolers’ financial and economic literacy in the context of cooperation between the kindergarten and the parents. The authors analyze the relevance and the need to teach children the basics of economics from an early age, it is emphasized that children face and deal with various economic concepts early, and the task of adults is to develop the basis of children’s economic thinking. The authors consider the foundations of financial literacy and a successful solution to this task in unity with morallabor education. The article describes the diagnostics, form, and control stages of the experiment in work with parents and children in the development of basic financial and economic literacy. The review of the stages covers the results of the diagnostics, an activity plan with parents and children, the final results of testing the developed approaches. In the content of economic education, the authors include such important tasks as the development of ideas about the professional activity of grown-ups, the family budget, money, advertising, the development of useful skills and habits in everyday life, etc. It is noted that rationally selected methods and means of education make it possible to introduce the child to the world of economics, to master complex financial categories and relations. The authors proved that the development of the elementary financial literacy of children is possible only in the cooperation and close interaction with the family.
Teaching Reading Digital Texts within Neuroscientific Achievements
Authors: Makotrova Galina V. , Moiseenko Olga A. , Shehovskaya Natalia L. , Krolevetskaya Elena N. , Korol Alexander I.
Published: February 2021

The authors consider the process of teaching learners reading digital texts as pedagogical support for their search activity. Taking into account psychophysiological regularities and psychological mechanisms a teacher gets an opportunity to simulate the environment and conditions for learners to form implications, formulate questions and implement research and search for new questions based on the obtained results with the help of hypertextuality, multimedia and interactivity of digital texts in a real educational process. The purpose of the study is to identify a strategy for reading digital text. The simulation experiment for senior learners includes two opposite ways of teaching reading digital text. He/she had to start first with the short text reading, then with the corresponding picture and vice versa. The personal significance of the read text or picture, understanding of the text content and the accuracy of its reproduction were taken into account. Experimental evidence suggests the importance of using strategies for teaching reading a digital text as strategies allow the learner to act as a subject of attitude to the subject of knowledge. Teacher’s digital text-based sequencing of learning situations, based on the principle of integrity, provides a sequence of future-oriented behavioral acts in the context of neuroscience achievements.
Low financial inclusion as an educational gaps result: the Republic of Moldova case
Authors: Cociug Victoria , Turcan-Munteanu Natalia
Published: February 2021

Financial inclusion has a significant role in increasing the quality of life of citizens, as it represents the model of access to financial products and services in order to meet their development needs in a sustainable and responsible way. In this article, we are aiming to analyse the educational deficiencies of the Republic of Moldova, resulting in low financial inclusion of the population, as well as to provide certain solutions to increase the level of economic education of the population at different stages of the educational process. The opportunity to study this subject refers to the need to implement various solutions in order to ensure an acceptable level of financial inclusion, which primarily involves the participation of educational institutions in the formation of financial skills and financial literacy. In order to study the subject approached in the article, there were used the following research methods: analysis, synthesis, induction, deduction, comparison, etc. The research results include the selection from the literature of the concepts on financial inclusion, financial education and their importance for the economic development, research on this subject based on the analysis of the education system in the Republic of Moldova and the formulation of the most relevant research findings, resulting in recommendations for actions needed to be implemented actions needed to be implemented in the emerging countries, such as the Republic of Moldova in order to increase the level of financial inclusion.
Methodical approach to building system of motivation of the project team
Authors: Glazkova Valeriya
Published: February 2021

Currently investment and construction activities are based on the implementation of development projects. As any project’s success heavily depends on joint efforts of a project team members, there is an urgent need for a motivation system able to stimulate team members’ result-orientation and satisfy their individual needs. The Project Management Body of Knowledge (PMBOK) methodology is suggested as a basis for building a sound development team motivation system, with its motivational tools correlating to stages of project management. The purpose of this article is to build methodical approach to system of motivation of the development project team. The methodological approach is formed taking into account the correspondence of the goal and the type of motivation depending on the stage of project management, as well as on the basis of the principles of forming the motivation system of the project team. The result is a constructed conceptual model for the development of a motivation system for the development project team based on the principles of PMBOK. Methods of comparative, empirical, system and economic analysis were used to substantiate the propositions put forward in the article.
Development of personal qualities of gifted students as the result of the implementation of individual educational routes
Authors: Kremneva Alena , Gumerova Marina , Zakharova Irina , Sadykova Lily , Rafikov Azat , Malikov Rustam
Published: February 2021

The need to create favorable conditions in schools to support gifted and talented students is due to the social order and humanistic paradigm of modern education. This article deals with the problem of developing personal qualities of students in the framework of pedagogical support for students with signs of giftedness in the modern school. The article reveals the results of the study of personal development of students accompanied by teachers in the process of designing and implementing individual educational routes at the main stage of general education. The leading method of studying this problem is the analysis of the results of the survey of teachers and schoolchildren in order to determine changes in the manifestation and development of personal qualities of students with signs of giftedness, accompanied by teachers, in the process of implementing their individual educational path using the model of the educational route developed by the authors of the article. The summary of the research presented in the article is the development and testing the structural-functional model of individual educational route for students with signs of giftedness, the use of which contributes to the manifestation and development of personal qualities of students required for the development of their potential and achieving educational outcomes. The materials of the article are of practical value for teachers when planning individual work at school.
Was uns antreibt und bewegt: ein Fokus auf individuelle Motive und Ziele in der Bewegungs- und Sportförderung
Authors: Gut Vanessa
Published: February 2021

„Liebe Leserinnen und Leser“,

Eine langfristige Bindung an Bewegungs- und Sportaktivitäten ist von zentraler Bedeutung, damit Personen von den zahlreichen positiven Effekten körperlicher Aktivitäten profitieren können. Die hohe Dropoutquote von 40 bis 60 % aus Gesundheitssportprogrammen verdeutlicht jedoch, dass es vielen Personen schwerfällt, sportlich aktiv zu bleiben.
Ein vermeintliches hepatozelluläres Adenom stellt sich als intrahepatische Splenose heraus – ein Fallbericht
Authors: Dölle Michael , Ringe Kristina Imeen , Hartleben Björn , Braubach Peter , Thol Felicitas , Gebel Michael , Wedemeyer Heiner , Potthoff Andrej , Zender Steffen
Published: February 2021

Wir berichten über einen 62-jährigen Mann, der mit epigastrischen Beschwerden in unsere Klinik überwiesen wurde. Die initial durchgeführte Ultraschalluntersuchung des Abdomens zeigte eine dezent echoarme 26 mm große Läsion in Segment 2 der Leber. In der kontrastgestützten Sonografie (CE-US) zeigte sich eine Hypervaskularisation mit zentripetaler Auffüllung und angedeutetem radiärem Gefäßmuster. In der portalen Phase und in der venösen Spätphase wurde das Kontrastmittel stärker als in der übrigen Leber gehalten, was an einen benignen Lebertumor, u. a. an ein hepatozelluläres Adenom (HCA), denken ließ. Eine fokal noduläre Hyperplasie (FNH) wäre eine mögliche Differenzialdiagnose gewesen. Ein im Anschluss durchgeführtes MRT konnte zwischen einem HCA und einem hepatozellulären Karzinom (HCC) nicht sicher unterscheiden, weswegen letztlich die Entscheidung zur Stanzbiopsie getroffen wurde. Die histopathologische und immunhistochemische Aufarbeitung offenbarte das Bild einer intrahepatischen Splenose. Die Neuerhebung der Anamnese ergab ein stattgehabtes Abdominaltrauma mit Milzruptur 5 Jahre zuvor. Die intrahepatische Splenose ist somit eine wichtige Differenzialdiagnose bei Patienten mit unklarem Lebertumor und der Vorgeschichte eines Milztraumas.
Clinical comparison of toxicity pattern of two linear quadratic model-baesd fractionation schemes of high-dose-rate intracavitary brachytherapy for cervical cancer
Authors: Batra Ankit
Published: February 2021

Introduction: Carcinoma cervix is the fourth (GLOBACON 2012) most common cancer among women worldwide, and the main cancer affecting women in Sub-Saharan Africa, Central America and south-central Asia. In India, approx. 1,23,000 (GLOBACON 2012) new cases of carcinoma cervix are diagnosed each year. Brachytherapy is an integral part of treatment of cancer cervix. In the context of a developing country like us where maximum utilization of the resource is of prime importance to provide treatment to the large patient cohort, shortening the treatment duration and number of fractions always increases efficiency. In order to maximize the logistic benefits of HDR-BT while improving patient compliance and resource sparing, various fractionation regimens are used. Fractionation and dose adjustments of the total dose are radiobiologically important factors in lowering the incidence of complications without compromising the treatment results.

Aim: To compare patient outcomes and complications using two linear-quadratic model-based fractionation schemes of high-dose-rate intracavitary brachytherapy (HDR-IC) used to treat cervical cancer.

Materials and Methods: A prospective randomized study on 318 patients, with histologically proven advanced carcinoma cervix (stages IIB-IIIB) was enrolled in the study. All patients received External Beam Radio Therapy (EBRT) 50 Gy in 25 fractions with concurrent chemotherapy (cisplatin 35 mg/m2) followed by IntraCavitary brachytherapy using high dose rate equipment. Patients were randomised after completion of EBRT into two arms: (1) Arm 1: HDR ICRT 6.5 Gy per fraction for 3 fractions, a week apart. (2) Arm 2: HDR ICRT, 9 Gy per fraction for 2 fractions, 1 week apart. On completion of treatment, patients were assessed monthly for 3 months followed by 3 monthly thereafter. Treatment response was assessed according to WHO criteria after one month of completion of radiotherapy. The RTOG criteria were used for radiation induced toxicities. We analyzed late toxicities in terms of Rectal, Bladder, Small Bowel toxicity and Vaginal Stenosis.

Results: Acute reactions in both the groups were comparable. None of the patient developed Grade 4 toxicity in our study and no toxicity related mortality was encountered. A slightly high frequency of late toxicity was observed in 9Gy Arm patients but was not statistically significant.

Conclusion: In our setup, HDR brachytherapy at 9 Gy per fraction in two fractions is safe, effective and resource saving method with good local control, survival, and manageable normal tissue toxicity.
Low dose radiation and chemotherapy significantly reduces hypoxic cell population in locally advanced cervix cancer-results of a phase II study
Authors: Das Saikat
Published: February 2021

Introduction: Tumor hypoxia is one of the major causes of high incidence of treatment failures to chemoradiation which is the standard of care in locally advanced cervical cancer. The necessity of newer treatment options that can circumvent hypoxia is highly relevant in this group. Use of low dose radiation to enhance the efficacy of cell cycle specific chemotherapy by mechanism of chemopotentiation is one of the elegant approaches reported in the literature. We have already published the feasibility, efficacy and tolerance of low dose radiation and chemotherapy in neoadjuvant setting in cervical cancer. In this report we evaluated the role of this novel treatment regimen in reducing the hypoxic tumor cell population in cervical cancer.

Methods: Total 24 patients with stage IIB-IIIB squamous cell carcinoma cervix were treated with initial 2 cycles of paclitaxel and carboplatin and concurrent low dose radiotherapy prior to standard chemoradiation. Response was assessed clinically, radiologically (by MRI) and pathologically (four quadrant representative punch biopsy from the cervix) after 3 weeks of neoadjuvant treatment prior to chemoradiation. Immunohistochemistry of HIF-1a was done in the biopsy samples to determine the proportion, intensity and scoring of hypoxic cells.

Results: The proportion of positivity of base line HIF-1α was 42% (10 out of 24 patients). Low, moderate and high expressions were seen in 8%, 17% and 17% respectively. We observed nuclear positivity in 20%, and fine granular perinuclear cytoplasmic positivity in 80% cases. We failed to observe any association between expressions of HIF 1α in relation to the distance from blood vessels in tumor cord. The average age of patients in hypoxia positive and negative groups were 51.7 vs 48.36 yrs (p > 0.05). There was no difference of mean hemoglobin level (11.3 to 11.1, p > 0.05.) or MRI based tumor volume at baseline (57.1 vs. 52.4, p > 0.05) in HIF 1α positive and negative groups respectively. Low dose radiation and chemotherapy significantly reduced the tumor volume in bulky hypoxic tumors. The tumor volume reduction rate (TVRR) was significantly higher in hypoxic group (TVRR HIF_neg vs. TVRR HIF_pos 68.9 vs. 86.3, p = 0.02, t-test). There was significant improvement of diffusion MRI derived apparent diffusion coefficient (ADC) in hypoxic tumors with low dose radiation and chemotherapy (0.75 vs. 1.27, p = 0.12, Wilcoxon signed-rank test). Median score of percentage of hypoxic cells after neoadjuvant treatment were significantly higher in patients who developed subsequent local recurrence than the rest of the group (77% vs. 5% p = 0.009, Mann Whitney U test).

Conclusion: Overall all HIF 1 positivity was 42% in the present study. A predominantly perinuclear pattern of HIF 1 staining was found in cervix cancer. Low dose radiation and chemotherapy significantly reduced the hypoxic tumor bulk in cervical cancer.
Incremental Role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in detection of recurrence of carcinoma cervix
Authors: Dash S. , Goel A. , Sogani S.
Published: February 2021

Purpose: To evaluate the role of 18F-FDG PET with contrast enhanced CT (PET-CECT) in early detection of recurrence in follow up patients of carcinoma cervix.

Methods: Patients with histopathologically proven carcinoma cervix who underwent chemotherapy, radiotherapy and/or surgery and on follow up were recruited in the study. Fifty-two patients underwent 18F-FDG PET-CECT for detection of recurrence. The median age was 51.5 (average = 53.4) years. PET-CECT studies were evaluated and analyzed separately by an experienced nuclear medicine physician and a radiologist independently. The physicians were blinded for the patient history. PET-CECT results were validated with histopathological correlation, conventional radiologic imaging/follow up PET-CECT study and clinical follow up.

Results: Out of 52 patients, 34 patients were reported as positive for recurrence, 17 of these were having active local recurrence and 31 patients had regional lymph nodal metastases, 14 patients had distant metastases (out of them 6 patients had distant lymph node metastases, 6 had pulmonary metastases, 4 had skeletal metastases and two had liver metastases). Remaining 18 patients were reported as negative for recurrence. The lung was the most common site for distant metastasis. Patient were then further evaluated based on histopathological correlation, conventional radiologic imaging and follow up PET-CECT scan and five were found to be false positive and one patient was identified as false negative. The sensitivity, specificity, positive and negative predictive value were derived to be 96.7%, 77.3%, 85.3% and 94.4%, respectively. Accuracy was calculated to be 88.5%.

Conclusions: 18F-FDG PET-CECT is a very useful non-invasive modality for the early detection of recurrence and metastatic workup in patients with carcinoma cervix with a very high sensitivity and negative predictive value. It is also useful in targeting biopsy sites in suspected cases of recurrence.
Nation wide urgent need for colposcopy services: Cancer hospital based study
Authors: Gahlot Vibha , Kumar Ranjit
Published: February 2021

The cancer cervix is the second most common cancer among women worldwide. About 86% of the cases occur in developing countries and this is responsible for 88% of total deaths. In India 132,000 new cases are diagnosed each year with this disease and 74,000 deaths are recorded annually which accounts for the 1/3rd of the global deaths from cervical cancer. This hospital based study is designed to look at the distribution of the disease in patients coming to the Mahavir Cancer Sansthan with the aim to achieve an early diagnosis and treatment and recognition of disease in its preinvasive state for better outcome and quality of life. The patient registry data in Mahavir Cancer Sansthan showed that the total number of patients from all cancer were 20,746 in year 2013-2014. The cervical cancer constituted 14% of the patients. 50% of the patients belong to the six district of Bihar which falls in Gangetic plain. 700 case notes have been reviewed for clinical staging at the time of the diagnosis. 71% of the patients were in stage 2b at the time of first clinical presentation, 24% in stage 3% and 4% were in stage 4. Only 1% patients were found in stage1. The colposcopy clinic data suggest only 0.04% patients have approached to us at preinvasive stage. We conclude from this study that although this hospital is mainly a referral cancer hospital 99% patient have reported to the hospital at stage 2b and beyond. Given the natural History of cervical cancer this is only the tip of iceberg. A robust system for colposcopy services needed to diagnose this disease at its preinvasive and micro invasive stage to reduce the morbidity and mortality and improvement in the quality of the life of the patients.
Over view of clinical presentation, management and outcome of cervical cancer: A tertiary cancer centre experience
Authors: Shukla H. , Batra K. , Sekhon R. , Giri S. , Rawal S.
Published: February 2021

Objectives: (a) To understand the profile of cervical cancer patients attending our hospital from January 2011 till January 2015. (b) To audit the type of care given to the patients with respect to their stage at presentation. (c) To compare the outcomes of open v/s robotic radical hysterectomy done for cervical cancer.

Methods: We prospectively analyzed all cases of cervical cancer from January 2011 to January 2015 presenting at our institute. Data was retrieved from patient’s records and institute’s tumor registry. We compared all patients undergoing open v/s robotic RH. All the data were analysed using SPSS version 21.

Results: A total of 562 patients were treated for cervical cancer during the time period between 2011-2015. Of these there were 316 (56%) cases taken up for surgery-212 robotic RH, 104 open radical hysterectomy and rest 246 (44%) patients received definitive CCRT. Most common age group was 40-54 yrs. IB1 stage was most common presenting stage. SCC was most common histology (75%). Immediate post op complication and oncological safety in terms of local recurrence was same in both groups. However length of stay and post operative blood requirement was significantly lower in robotic RH group. 45% of all patients who underwent surgery did not require adjuvant therapy in post op period while 35% patient required post op RT and 20% CCRT. 2.2% patient had local recurrence and most of the patients were in stage IIA1 at presentation.

Conclusion: Cervical cancer is the most common gynecological cancer in our hospital registry. Mostly women were in the age group of 40-54 years. Most common stage at presentation was 1B and the histology being SCC. Not many differences seen in open v/s robotic techniques of radical hysterectomy except for shorter hospital stay and less need of blood transfusion in the robotic group. Local recurrence rates are comparable in both open and robotic groups.