bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of hydrogen sulfide metabolism modulators on CSE gene expression, levels of proinflammatory and profibrotic mediators, morphological changes in cardiovascular system of rats in experimental obesity
Authors:   National Pіrogov Memorial Medical University, BOBETSKA O. P. , ZAICHKO N. V. ,   National Pіrogov Memorial Medical University
Published: February 2024

Hydrogen sulfide (H 2 S) is considered to be a multifunctional mediator. Disorders of H 2 S synthesis are related to the pathogenesis of cardio- vascular pathology. Approaches to H2 S metabolism correction in cardiovascular system in obesity are not defined. The aim of study: to estimate the effect of H 2 S metabolism modulators on CSE gene expression, levels of proinflammatory and profibrotic mediators, morphological changes in cardiovascular system of rats in experimental obe- sity (EO). Methods. The experiments were carried out on 70 white non-linear male rats. The care and use of laboratory animals were approved by the general principles of bioethics (Strasbourg, 1986). EO was induced by a high-calorie diet application during 10 weeks. The 8-10-th weeks of the experiment was the period when H 2 S metabolism modulators were administered. The expression of CSE gene, levels of visfatin, TNFα, endothelin-1 and morphological changes were estimated in cardiovascular system. Results. EO results in CSE gene oppression in myocardium and aorta, therewith elevation of visfatin and TNFα levels in myocardium occurs, serum level of endothelin-1 increases, morphological features of cardiomyopathy re- veal furthermore. H 2 S donor (NaHS) and cofactors (α-lipoic acid, zinc sulfate) upregulate CSE gene expression, perform an adjusting effect on biochemical disturbances, reduce signs of cardiomyopathy, while propargylglycine (cysta- thionine-γ-lyase inhibitor) induces the opposite effects. Conclusions. H 2 S is involved in regulation of inflammatory and fibrogenic mediators in cardiovascular system in obesity. Cofactors of H 2 S metabolism effectively correct cardiometabolic disorders in this condition
GENDER DIMORPHISM OF CHANGES IN THE SKIN MICROCIRCULATION OF RATS ON THE BACKGROUND OF ACUTE COLD TRAUMA
Authors:   National Pirogov Memorial Medical University, VOLOSHCHUK N. I. , YUHIMCHUK A. V. ,   National Pirogov Memorial Medical University
Published: February 2024

Gender factors play an important role in the prevention, preva- lence and specifics of the course of various pathological conditions, among which cold injury occupies an important place. The role of gender in its pathogenesis remains poorly understood. The aim. To assess sex-specific changes in the microcirculation of target organs exposed to extremely low temperatures during experimental acute cold trauma (ACT) in rats. Materials and methods. Experiments were performed on male and female sexually mature and castrated Wistar rats. Acute cold trauma (ACT) was modeled by keeping the animals at -180ºС for 2 hours. The microcirculation coefficients of the skin of the hind limbs, auricles, and tail of animals were determined using Biopas electrophysiological equipment (USA) non-invasively using a surface sensor. We compared the changes before and 30 minutes after the action of the cold factor. Statistical processing of the results was carried out using standard descriptive methods. The results. A 2-hour stay of animals under the influence of extremely low temperatures causes a significant drop in blood supply in animals of both sexes. The degree of changes has a clear sexual dimorphism with a predom- inance of pathological processes in male animals. In males, the coefficient of microcirculation of the lower limbs and auricles decreased by 72.2 and 55.3 %, and in the tail by 35.1 %, compared to this indicator before the effect of the cold factor (p < 0.05), on the other hand, in female rats changes in similar indicators were 66.5 and 44.3 % (lower limbs and auricles), and tail perfusion by 18.6 % (p < 0.05). ACT in castrated female rats caused more extensive hemoperfusion disorders compared to males: the microcirculation index of the tail, hind limbs, and auricle in male rats on the background of ACT decreased by 25.4, 66.4, and 40.7 %, respectively (p < 0.05), whereas in animals of the opposite sex – by 32.5, 78.8 and 47.4 %, respectively. Conclusion In sexually mature female rats without changes in hormonal status, a greater resistance to microcirculation disorders during experimental acute cold injury was found. The reason for these differences is the effect of sex hormones, since castration of males increases the resistance of the vascular system of animals to the action of a cold factor, while ovariectomy of females – on the contrary, increases the degree of microcirculatory lesions of the most vulnerable organs to the action of extremely low temperatures
Emprendedor sustentable y acciones de interacción social, experiencias desde el noroeste de México
Authors: Pérez Núñez Sylvia Mónica
Published: February 2024

El artículo tiene como objetivo contribuir al desarrollo de conocimiento sobre emprendimiento sustentable de la región del sur global, describiendo las diversas formas en las que los emprendedores interactúan en el espacio social. Se estudiaron tres empresas sustentables del sector gastronómico del noroeste de México, centrando la atención en las diversas acciones de interacción social en la que estos emprendedores sensibilizan y educan a la comunidad local sobre vida sustentable a través de su modelo de negocio. Se utilizó la herramienta para análisis cualitativo ATLAS.ti para codificar el texto de las entrevistas. Los resultados indican que estos emprendedores concientizan a sus colaboradores y clientes sobre reciclaje, cuidado del medio ambiente, adaptación a las condiciones locales y modificar hábitos de consumo. Para estos emprendedores el desarrollo sustentable es un estilo de vida que comparten con su comunidad mediante diversas acciones de interacción social.
Contaminación Hídrica y Derecho a la Seguridad Alimentaria de Comunidades Indígenas Andino-bolivianas del Titicaca en la cuenca Katari
Authors: Rivera Gironas Nicole , Garnica Gonzalez Camila Abril , Salvatierra Terrazas Belen Isamar , Villafuerte Philippsborn Leonardo , Agramont Akiyama Afnan
Published: February 2024

Las comunidades Indígenas Andino-bolivianas del Titicaca dependen a menudo de sus recursos naturales para garantizar su seguridad alimentaria, lo que las hace especialmente vulnerables a fluctuaciones ambientales y cambios en el ecosistema. Bajo ese criterio, el presente estudio aplica una metodología cualitativa para analizar la relación existente entre la seguridad alimentaria de las comunidades de la región de la bahía de Cohana (tomando como caso de estudio a la comunidad de Chojasivi) y la contaminación hídrica presente en la cuenca Katari. Los resultados revelan que dicha contaminación ha generado un efecto potencial en el acceso, disponibilidad, uso y estabilidad en el tiempo de los alimentos que componen la canasta básica de los comunarios.
The Russian historical and literary context of the novels by Guillaume Musso and prose by Marina Tsvetaeva
Authors: Tsaregorodtseva Svetlana Sergeevna , Pinaev Sergei Mikhailovich
Published: February 2024

The purpose of this study is to identify the Russian historical and literary context in Marina Tsvetaeva's prose of the emigrant period and in the novels of Guillaume Musso. The modern French writer Guillaume Musso is the author of two dozen novels, which (except for "Skidamarink", 2001) were translated into Russian and published in Russia. In almost every one of these novels, one can "discover" the Russian historical and literary context. This will be the main object of our research in the framework of the article (the analysis of the entire multicultural contextual complex of G. Musso's novels requires a more extensive consideration). The main subject of the article is a trilogy of novels about writers: "The Girl and the Night", "The Secret Life of writers" and "Life as a Novel", as well as the adjacent novel "Paper Girl", the main character of which Tom Boyd is a famous writer. Since in the novels Musso refers to meta-narrative, the creation of a meta-text, which involves commenting on the novel by the author, inviting the reader to his creative laboratory, and also requires identifying the historical and cultural context. The novel "The Girl and the Night" by G. Musso is considered in comparison with the "Tale of Sonechka" by M. Tsvetaeva and requires an appeal to the vital biographical context. Russian historical and literary context of the "writer's" cycle of novels by Guillaume Musso and prose by Marina Tsvetaeva" for the first time revealed intertextual connections of novels by the most popular French writer Guillaume Musso with works of Russian literature: emigrant prose by Marina Tsvetaeva, works by F.M. Dostoevsky, I.S. Turgenev and other writers. The authors of the article pay special attention not only to the intertextual connections of Russian and French prose of the XX-XXI century, but also to the peculiarities of the plot structure of modern literature. This study attempts to identify the main trends in modern literature and trace their reflection in the works of G. Musso. The main conclusion that the authors of the article make is that in Musso's prose, the Russian text can be identified at all contextual levels: vital-biographical, literary, historical, cross-cultural.
Evolutionary Reinforcement Learning: Hybrid Approach for Safety-Informed Fault-Tolerant Flight Control
Authors: Gavra Vlad , van Kampen Erik-Jan
Published: February 2024

Recent research in artificial intelligence potentially provides solutions to the challenging problem of fault-tolerant and robust flight control. This paper proposes a novel Safety-Informed Evolutionary Reinforcement Learning algorithm (SERL), which combines Deep Reinforcement Learning (DRL) and neuroevolution to optimize a population of nonlinear control policies. Using SERL, the work has trained agents to provide attitude tracking on a high-fidelity nonlinear fixed-wing aircraft model. Compared to a state-of-the-art DRL solution, SERL achieves better tracking performance in nine out of ten cases, remaining robust against faults and changes in flight conditions, while providing smoother action signals.
Education as Liberation: An Appraisal of Canaan Banana’s View on Education
Authors: Kumalo Simangaliso Raymond , Taruona Honoured
Published: February 2024

Canaan Sodindo Banana, a freedom fighter, statesman, academic and cleric, is arguably the most controversial clergyman from Zimbabwe. He was a polarising figure in both his personal life and academic writings. Much is known about his political legacy, but very little about his educational views. This essay appraises Banana's views on the content and purpose of education in a post-white settler society. The essay employs document analysis to review Banana’s views on education and concludes that his view was that education should liberate and empower the poor, particularly the previously disadvantaged.
Effective combinations of glucose-lowering drugs in patients with obesity and type 2 diabetes mellitus during the treatment of diabetic foot syndrome
Authors: Turova T. G. , Paskhalova Yu. S.
Published: February 2024

The article provides a brief analysis of the action mechanisms of modern combinations by glucose-lowering drugs for type 2 diabetes mellitus, diabetic foot syndrome and obesity. Using the example of clinical observations, the positive dynamics of reducing body weight and glycated hemoglobin was demonstrated. It also shows how good control of type 2 diabetes makes it possible to effectively treat such a formidable complication as diabetic foot syndrome.
A mortalidade materna na Amazônia: um retrato da Região Xingu no estado do Pará
Authors: Silva Laise Lourrany da , Aarão Tinara Leila de Souza , Farias Ilka Lorena de Oliveira
Published: February 2024

Objetivo: Analisar o perfil de mortalidade materna nos municípios da região de saúde do Xingu do Estado do Pará no período de 2010 a 2021. Métodos: Trata-se de um estudo epidemiológico, retrospectivo, descritivo, transversal com abordagem quantitativa sobre o perfil de mortalidade materna, nos municípios da Região Xingu do Estado do Pará no período de 2010 a 2021.  A coleta dos dados foi realizada no Sistema de Informações de Mortalidade (SIM), uma base do Departamento de Informática do Sistema Único de Saúde (DATASUS), em novembro de 2022. Resultados: No período estudado verificou-se que os piores índices de mortalidade materna são dos municípios de Anapu, Pacajá, Porto de Moz e Medicilândia. Das causas dessas mortalidades obteve-se 46 óbitos por causas diretas e 10 por causas indiretas. Dessas, 73,21% tinham entre 15 e 29 anos, 67,86% eram solteiras, 64,28% tinham entre 4 e 11 anos de estudo, 51,78% ocorreram no puerpério e os piores índices de consultas pré-natal são de Porto de Moz, Altamira e Senador José Porfirio. Conclusão: Depreende-se que de estrutura física, os municípios devem investir em pré-natais de qualidade, um bom fluxo de referenciação no serviço e condições de acesso a saúde a todos.
Oral squamous cell carcinoma: A case report with scanning electron microscopy, Mallory’s, Masson’s trichrome, orcein, and Papanicolaou staining
Authors: Manishankar Suraj , Tamgadge Sandhya , Pereira Treville , Tamgadge Avinash
Published: February 2024

Squamous cell carcinoma is a malignant epithelial tumor with squamous differentiation. It is characterized by formation of keratin or presence of intercellular bridges. This neoplasm is also known as epidermoid carcinoma and is the second most common malignant neoplasm of the oral cavity. This neoplasm is seen more frequently in the lower lip, tongue, floor of the mouth, upper lip, buccal mucosa, gingiva, and in some cases, in the hard palate and maxillary sinus. Multiple reports on oral squamous cell carcinoma (OSCC) are found in the literature but very few report the various investigations done using special stains and scanning electron microscopy. There is a need for investigations using special stains as it is less expensive and may also help in identifying various characteristics of OSCC. Here, we present a case report of well-differentiated squamous cell carcinoma in a 60-year-old male patient with complaints of pain and ulcers on both cheeks for 2–3 months.
From sand to development: Autopsy of the sand-Sanaga sector in the Commune of Ebebda, Center Region-Cameroon
Authors: MESSI Paul Basile ELOUNDOU , VOUNDI Éric
Published: February 2024

L’urbanisation progresse rapidement au Cameroun. Elle a atteint un taux de 54 % en 2015 (INS, 2015). L’accroissement démographique en ville stimule l’essor du marché immobilier ; les matériaux de construction sont recherchés. La demande du sable à Yaoundé montre une préférence pour le sable extrait du fleuve Sanaga. Dans la localité d’Ebebda, il s’est structuré une « filière-sable ». Cet article analyse la filière « sable-Sanaga » d’Ebebda afin d’évaluer sa contribution dans le développement de la commune et les problèmes liés. Les recherches combinent revue de la littérature et investigations de terrain auprès de divers acteurs. Il en ressort que la filière « sable-Sanaga » est très dynamique. Elle est source de retombées socio-économiques importantes pour les populations et déterminantes dans le développement de la commune. L’extraction du sable dans la Sanaga est devenue la principale activité économique pour beaucoup de personnes et source de revenus pour la Mairie.
Spatial distribution of health establishments and their impact on inequalities of access to care in Algiers
Authors: Tarek MEDJADJ , Guy BAUDELLE
Published: February 2024

L’article analyse la répartition des établissements de santé dans leurs relations avec les inégalités d’accès aux soins dans une ville où la poussée démographique et l’urbanisation accélérée créent de nouveaux défis sanitaires notamment dans les nouvelles zones d’habitat périphériques. La wilayat d’Alger, périmètre de notre étude, a pourtant bénéficié d’une enveloppe budgétaire importante en matière d’infrastructures sanitaires au point de former aujourd’hui la principale concentration d’équipements de santé du pays. On analyse la densité des services sanitaires à partir d’un système d’information géographique en développant une méthode d’estimation de la densité appelée Kernel density. Les résultats montrent des disparités d’accès aux soins en raison d’une inégale répartition des équipements sanitaires entre le centre et une périphérie en expansion. On constate que dans le contexte d’une grande ville du Maghreb, l’offre et l’accès aux soins sont le plus souvent déterminés par le système de gestion des infrastructures de santé.
What measures should be taken to control the artificialisation of land? A comparison between the French, English and Walloon systems
Authors: TEVEL Noémy
Published: February 2024

L’artificialisation des sols impacte négativement le processus de changement climatique. L’Union européenne a donc décidé d’imposer à ses membres de prendre des mesures pour la réduire. En Wallonie, le Schéma de Développement Territorial donne, entre autres, l’objectif de tendre vers l’implantation des nouveaux logements dans les centralités, ainsi que sur des terres déjà artificialisées. Le Royaume-Uni et la France gèrent également leur territoire de manière à en réduire l’artificialisation. Chaque législation est empreinte du contexte dans lequel elle a été prise, difficultés socio-économiques, crise du logement ou encore crise politique. Pour assurer le suivi des différents objectifs, des méthodes de monitoring sont nécessaires, mais la Wallonie n’a pas encore de méthode systématisée. Une piste serait de s’inspirer de la méthode française qui emploie les informations cadastrales. Il semble, néanmoins, que la méthode britannique, croisant l’occupation du sol et le cadastre soit plus adaptée à la réalité wallonne.
Intensive Microalgal Cultivation and Tertiary Phosphorus Recovery from Wastewaters via the EcoRecover Process
Authors: Molitor Hannah , Kim Ga-Yeong , Hartnett Elaine , Gincley Benjamin , Alam Md Mahbubul , Feng Jianan , Avila Nickolas , Fisher Autumn , Hodaei Mahdi , Li Yalin , McGraw Kevin , Cusick Ro , Bradley Ian , Pinto Ameet , Guest Jeremy
Published: February 2024

Mixed community microalgal wastewater treatment technologies have the potential to advance the limit of technology for biological nutrient recovery while producing a renewable carbon feedstock, but a deeper understanding of their performance is required for system optimization and control. In this study, we characterized the performance of a 568 m3·day-1 Clearas EcoRecover system for tertiary phosphorus removal (and recovery as biomass) at an operating water resource recovery facility (WRRF). The process consists of a (dark) mix tank, photobioreactors (PBRs), and a membrane tank with ultrafiltration membranes for the separation of hydraulic and solids residence times. Through continuous on-line monitoring, long-term on-site monitoring, and on-site batch experiments, we demonstrate (i) the importance of carbohydrate storage in PBRs to support phosphorus uptake under dark conditions in the mix tank and (ii) the potential for polyphosphate accumulation in the mixed algal communities. Over a 3 month winter period with limited outside influences (e.g., no major upstream process changes), the effluent total phosphorus (TP) concentration was 0.03 ± 0.03 mg-P·L-1 (0.01 ± 0.02 mg-P·L-1 orthophosphate). Core microbial community taxa included Chlorella spp., Scenedesmus spp., and Monoraphidium spp., and key indicators of stable performance included near-neutral pH, sufficient alkalinity, and a diel rhythm in dissolved oxygen.
Speciation of the proton in water-in-salt electrolytes
Authors: Goloviznina Kateryna , Serva Alessandra , Salanne Mathieu
Published: February 2024

Water-in-salt (WiS) electrolytes are promising systems for a variety of energy storage devices. Indeed, they represent a great alternative to conventional organic electrolytes thanks to their environmental friendliness, non-flammability, and good electrochemical stability. Understanding the behaviour of such systems and their local organisation is a key direction for their rational design and successful implementation at the industrial scale. In the present paper, we focus our investigation on the 21 m bis(trifluoromethanesulfonyl)imide (LiTFSI) WiS electrolyte, recently reported to have acidic pH values. We explore the speciation of an excess proton in this system and its dependence on the initial local environment using ab initio molecular dynamics simulations. In particular, we observe the formation of HTFSI acid in WiS system, known to act as a superacid in water. This acid is stabilised in the WiS solution for several picoseconds thanks to the formation of a complex with water molecules and a neighboring TFSI– anion. We further investigate how the excess proton affects the microstructure of WiS, in particular, the oligomerisation of lithium cations, and report possible notable perturbations of lithium nanochain organisation in some cases. These two phenomena are particularly important when considering WiS as electrolytes in batteries and supercapacitors, and our results contribute to the comprehension of these systems on the molecular level.
Alopecia prevention during chemotherapy: from the benchmark to real clinical practice. A prospective study
Authors: Lyadova Marina A. , Nersesova Tatiana A. , Zhuravleva Anastasia A. , Fedorinov Denis S. , Dudnik Anna A. , Denisova Elena A. , Nosova Margarita V. , Pardabekova Olesya A. , Lisitsyna Kristina N. , Tuleiko Veronika M. , Bikmurzina Olesya A.
Published: February 2024

Background. Alopecia is one of the main side effects of anticancer chemotherapy and has a significant impact on patients’ appearance, quality of life, social adaptation and mental health of cancer patients. Estimated number of new cancer diagnosis increases annually alongside with the proportion of patients receiving chemotherapy. That means an annual increase in the global burden of chemo-induced alopecia and associated negative consequences. The development of various methods for the prevention of alopecia in cancer patients has continued for decades. However, convincing data have been obtained only for the scalp hypothermia method. In this point, the Paxman company’s cooling systems (UK) – the Orbis and Orbis II devices – have been most widely studied. Despite the fact that Orbis devices were approved in Russia more than 10 years ago, since then just a small amount of real clinical practice has been accumulated and questions regarding the effectiveness of scalp hypothermia in patients with variable cancers still remain open.
Aim. Analysis of local clinical practice with scalp hypothermia via the Orbis II device for the prevention of alopecia in patients receiving various chemotherapy regimens.
Materials and methods. An open, prospective, single-center study included patients with various cancer types who were indicated for chemotherapy. Orbis II device was used for prophylactic hypothermia. The severity of alopecia was assessed according to the CTCAE version 5.0 at baseline and during anticancer therapy.
Results. From June 2022 to May 2023, scalp cooling procedures were performed in 51 patients, of them 78% of all procedures were performed in female cancers: breast tumors – 109 (52.2%) procedures, ovarian cancer– 33 (15.8%), and cervix cancer – 22 (10.5%). The effectiveness of scalp hypothermia in preventing of severe alopecia was 73%.
Conclusion. Scalp cooling can be considered as an effective method for the prevention of chemotherapy induced alopecia. Further studies are needed to assess larger patient populations to identify favorable and negative factors that affect potency of the hypothermia.
The use of hydroxyethyldimethyldihydropyrimidine to improve regeneration processes in a postoperative wound after sectoral resection of the breast
Authors: Shabaev Ramis M. , Khodyrev Sergey A. , Kolyadina Irina V. , Blagovestnov Dmitry A. , Starokon Pavel M.
Published: February 2024

Background. Partial mastectomy is the method of choice for the surgical treatment of benign neoplasms (BN) of the breast. The drawback of this technique is the occurrence of residual cavities with the accumulation of serous and hemorrhagic exudate, promoting inflammation. Hydroxyethyl dimethyldihydropyrimidine (Ximedon) in the postoperative treatment improves the healing and overall treatment outcomes.
Materials and methods. The study included 101 patients. All of them had a partial mastectomy for the BN. The study patients received different pharmacotherapy in the postoperative period. They were divided into two groups depending on the use of hydroxyethyl dimethyldihydropyrimidine. Group 1 included 52 (51.5%) patients who received hydroxyethyl dimethyldihydropyrimidine 2 hours before surgery and 0.5 g on days 1 to 7 in the postoperative period. Group 2 included 49 (48.5%) patients who had not received hydroxyethyl dimethyldihydropyrimidine.
Results. Analysis of treatment outcomes showed that in group 1 patients receiving hydroxyethyl dimethyldihydropyrimidine, the overall treatment results were better. Therefore, hydroxyethyldimethyldihydropyrimidine improved overall treatment outcomes and increased patients' quality of life in the postoperative period.
Conclusion. The use of hydroxyethyldimethyldihydropyrimidine in the postoperative period, which has a protective effect at the cellular level due to membrane-stabilizing, antioxidant, adaptogenic, and antibacterial properties, is promising and improves wound healing, thus improving the overall results of surgical treatment of breast BNs.
Scalp hypothermia for the prevention of chemotherapy-induced alopecia in breast cancer
Authors: Ognerubov Nikolai A. , Barsukov Sergei V.
Published: February 2024

Background. Breast cancer (BC) is a socially significant disease in women all over the world, ranking 1st in the structure and 5th in the number of deaths. Polychemotherapy in the complex treatment of BC accounts for approximately 80%. The main side effect that significantly affects the quality of life is alopecia, which occurs on average in 65% of patients.
Aim. To evaluate the efficacy and tolerability of scalp hypothermia (SHT) for the prevention of chemotherapy-induced alopecia in patients with BC.
Materials and methods. From June 2016 to September 2023, 75 patients with a median age of 44.1 years with stage I–IV BC were observed. All patients received cytotoxic therapy at various stages of treatment. To prevent alopecia, local SHT was used using an Orbis II device (Paxman Coolers, United Kingdom).
Results. Stage I of the disease was observed in 18 (24%) patients, stage II in 22 (29.3%), stage III in 30 (40%), and stage IV in 5 (6.7%). Patients received 5 different neo- and adjuvant regimens of polychemotherapy. Taxane-containing combined regimens prevailed. 364 SHT sessions (4–8 sessions per patient) were performed; 48 (64%) patients received the procedure in full. Complete hair preservation was achieved in 43 (57.3%) patients. Grade 1 alopecia was observed in 19 (25.4%) patients and grade 2 in 9 (12%) patients. Of the 5 patients with advanced BC, grade 2 alopecia was reported in 1 patient, grade 3 in 3, and grade 4 in 1. Side effects were reported in 16% of cases; the most common were a feeling of cold and a slight headache. Due to the intolerance of the cold helmet, 3 patients refused to use it. No scalp metastases were observed during the follow-up. During the procedure, almost all patients noted a high level of comfort.
Conclusion. Local SHT is an effective method of preventing cytotoxic therapy-induced alopecia in patients with BC. It improves the psychological and social adaptation of patients.
Grewia hirsuta Vahl Chemical Constituents and Biological Activities
Authors: Chikkamath Vinuth , H Kulkarni Venkatrao , V Habbu Prasanna , V Kulkarni Preeti
Published: February 2024

Grewia hirsute is also known as Nagbala a member of malvaceae family is small tree or shrub grown in mixed deciduous open and dry evergreen forests. In folk and tribal medicine it is used as nervine brain tonic antipyretic diuretic carminative aphrodisiac cardiac tonic. The plant is known to contain phenolics vanillic syringic melilotic p- hydroxy benzoic and protocatechuic acids flavonol kaempferol saponins tannins glycosides alkaloids anthraquinones steroids. The plant possesses antidiabetic antiproliferative antioxidant analgesic antiinflammatory antimicrobial activity. This review provides a birdrsquos eye view about phytoconstituents and pharmacological properties of Grewia hirsuta.
Contribuições e limitações da graduação para o gerenciamento de enfermagem
Authors: Ogliari Karina
Published: February 2024

Este estudo teve como objetivo compreender contribuições e limitações do aprendizado nagraduação sobre ações de gerenciamento em enfermagem sob a visão de estagiários. Trata-se depesquisa qualitativa feita em instituição de ensino superior. Os convites foram realizados até asaturação dos dados, alcançando dez participantes. Após o tratamento dos dados, emergiram duascategorias: processo de formação gerencial e desenvolvimento de habilidades gerenciais. Osestudantes apontaram dificuldades para conectar gerência e assistência, sinalizando acomplexidade da compreensão do conceito de gerenciamento do cuidado nessa etapa daformação profissional. Esse aspecto foi destacado como possível limitação, frente à importânciade os aspectos gerenciais subsidiarem a assistência. Outro elemento indicado foi odistanciamento entre alguns estudantes e disciplinas que abordam explicitamente a temáticasobre gerenciamento em enfermagem. As contribuições foram significadas com base nas atividades de estágios nos dois últimos semestres do curso. Apesar de os entrevistados realizarem atividades de gerência concomitantes às de assistência, esse movimento parece imperceptível aeles. Assim, faz-se necessário fortalecer o vínculo entre gerenciamento e teoria e práticas de enfermagem, para que, desse modo, seja possível atender às demandas definidas pela formação de competências, na medida em que se esclareçam as nuances do gerenciamento do cuidado.
coordenador da Atenção Primária e seu novo papel na Estratégia Saúde da Família
Authors: Rodovalho Giovanna Brunelli , Japiassu Renato Barbosa , Rached Chennyfer Dobbins Abi , De Liberal Márcia Mello Costa
Published: February 2024

Desde o início da Estratégia Saúde da Família (ESF) no Distrito Federal (DF), algumas mudanças no processo de trabalho têm sido gradualmente incorporadas; porém, o que se pode observar é que alguns coordenadores tendem a isolar-se, acomodando-se em suas funções e demonstrando resistência para atuarem em diferentes programas. Os coordenadores devem considerar que as ações em saúde dentro do novo modelo são realizadas de acordo com os dados epidemiológicos de cada região adscrita, sendo importante expandir seus olhares para além do seu programa. Foi realizada uma pesquisa qualitativa com aplicação de entrevista semiestruturada. Os achados encontrados foram que alguns coordenadores acreditam que a ESF foi implantada de forma ineficiente, com falta de recursos e planejamento, resultando em descrédito dos profissionais de saúde e da população. Outros coordenadores entrevistados apontaram como principais dificuldades a fragmentação do atendimento, falta de apoio de gestores locais para a mudança de modelo, escassez de recursos humanos, demanda incompatível com a capacidade instalada e dificuldade de comunicação entre ESF e Centro de Saúde. Pode-se concluir que os coordenadores compreendem o funcionamento da ESF e têm buscado estreitar os laços com as equipes e trabalhar de forma integrada.
Os trabalhadores farmacêuticos na atenção básica de Porto Alegre e a pandemia de coronavírus
Authors: Klimkowski Argoud Vanessa , Da Silva Diefenthaeler Sibeli , Rigo Ana Paula
Published: February 2024

Os trabalhadores do Sistema Único de Saúde (SUS) vivenciam as implicações da atual configuração do mundo do trabalho, pautada pela flexibilização dos direitos trabalhistas e sobrecarga de trabalho, contexto agravado pela pandemia de COVID-19, trazendo implicações particulares para a categoria dos farmacêuticos. Esta pesquisa objetiva analisar a configuração do trabalho dos farmacêuticos da Atenção Básica de Porto Alegre durante a pandemia de coronavírus. A pesquisa é qualitativa com propósito descritivo - exploratória, conduzida através de entrevistas coletadas dos farmacêuticos das Farmácias Distritais do município, interpretadas pela análise de conteúdo de Pagés na perspectiva teórica do materialismo-histórico-dialético. A análise resultou nos temas dominantes: (1) O trabalho do Farmacêutico na Atenção Básica, (2) Condições de trabalho do Farmacêutico nas Farmácias Distritais, (3) Precarização do trabalho nas Farmácias Distritais e (4) O trabalho do farmacêutico nas Farmácias Distritais durante a pandemia de coronavírus. A pandemia evidenciou à categoria o potencial de seu trabalho no SUS, em especial, na prática da educação em saúde, e, ao mesmo tempo, que são necessárias melhores condições de trabalho para qualificar a prática profissional.
Analysis Of Urban Planning Instruments in Comala, Colima, Mexico (1997–2009) from a Gender Perspective — A Secondary Publication
Authors: Garcia Espiritu E. J. , Chung Alonso P. , Barajas Avalos I. , Covarrubias Ruesga M. S. R. , Ramirez Rivera M. P.
Published: February 2024

This work is carried out based on the analysis of urban planning instruments, taking the gender perspective as a foundation. It arises from the inclusion of women in the participation of urban development, through an analysis of the gender gaps that have marked the history of women, the inequalities serve as a basis for carrying out this study. It highlights the challenges we face today as a society in the process of building citizen participation, where we must all be recognized and have equal opportunities within the territory in which we live. This article analyzes the extent to which the Municipal Urban Development Programs of the Mexican municipality of Comala, Colima, Mexico, consider the recommendations on gender and urbanism, established since the 1990s by international entities and applied transversally to urban planning policies. Considerable differences are found between women and men in terms of empowerment and participation in urban territorial planning instruments, mainly in the oldest instrument (1997). Significant progress is observed in the most recent document and is currently in force in the municipality of Comala (2009).
Research on Modulation Signal Denoising Method Based on Improved Variational Mode Decomposition
Authors: Mo Canyu , Lin Qianqiang , Niu Yuanduo , Du Haoran
Published: February 2024

In order to further analyze the micro-motion modulation signals generated by rotating components and extractmicro-motion features, a modulation signal denoising algorithm based on improved variational mode decomposition (VMD)is proposed. To improve the time-frequency performance, this method decomposes the data into narrowband signalsand analyzes the internal energy and frequency variations within the signal. Genetic algorithms are used to adaptivelyoptimize the mode number and bandwidth control parameters in the process of VMD. This approach aims to obtain theoptimal parameter combination and perform mode decomposition on the micro-motion modulation signal. The optimalmode number and quadratic penalty factor for VMD are determined. Based on the optimal values of the mode numberand quadratic penalty factor, the original signal is decomposed using VMD, resulting in optimal mode number intrinsicmode function (IMF) components. The effective modes are then reconstructed with the denoised modes, achieving signaldenoising. Through experimental data verification, the proposed algorithm demonstrates effective denoising of modulationsignals. In simulation data validation, the algorithm achieves the highest signal-to-noise ratio (SNR) and exhibits the bestperformance.
Prevalencia de homofobia en adolescentes de una institución educativa de la localidad de Suba en la ciudad de Bogotá.
Authors: Gonzalez Quiñones Juan Carlos , Morales V. Angie Viviana , Palacios C Paula Andrea , Pantoja L Cindy Juliana , Pardo M Yeri Alexandra
Published: February 2024

Introducción: La homofobia es un importante problema social, en particular para los adolescentes. La discriminación y el desprecio a que son sometidos aquellos adolescentes homosexuales o los que tienen dudas en torno a su identidad sexual, tiene consecuencias adversas en todo su desarrollo ulterior. Detectar y enfrentar conductas homofóbicas en los colegios, resulta clave si pretendemos una sociedad justa y sana, donde la convivencia con la diversidad se respete. La UNESCO invita a todas las sociedades a enfrentar estas conductas desde la ética individual y las políticas públicas en ambientes escolares.
Objetivos: Conocer la prevalencia de homofobia en los adolescentes escolarizados de un colegio de la localidad de suba en la ciudad de Bogotá e identificar los métodos preventivos.
Metodología: Se aplicó una encuesta presencial auto diligenciada y dicotómica a estudiantes de sexto a once grados, indagando por variables sociodemográficas y utilizando un test cuantitativo, en donde el total de su sumatoria indica si es o no homofóbico.
Resultados: Se encuestaron 843 estudiantes. El 24,9% de la población encuestada no son homofóbicos, el 49,1% aún tienen algunos prejuicios y el 26% son homofóbicos. Se compararon los  homofóbicos versus los no homofóbicos entre sexo femenino y masculino obteniendo como relaciones significativas un OR de 0.25, IC 95% Li 0.16 y Ls 0.37, también se comparó la homofobia versus la no homofobia entre edades de 13-15 años con 10-12 años obteniendo  OR de 0.43, Li 0,27 y Ls 0,70, entre edades de 16-19 años con 10-12 años obteniendo OR de 0.3, Li 0.17 y Ls 0.51 y finalmente entre edades de 16-19 años con 13-15 años obteniendo OR 0.68, Li 0.42 y Ls 1.09.
Conclusión: La homofobia es un rechazo que se puede generar de manera involuntaria a través del desprecio y la discriminación, ya que no se tiene en común la misma orientación social, pensamientos o ideologías. Se encontró que el 26% de los adolescentes escolarizados son homofóbicos. Se evidenció mayores actitudes homofóbicas en el sexo masculino que el femenino y se observó que entre menos edad entre los adolescentes, hay más actitudes homofóbicas.
Zarządzanie pierwiastkami ziem rzadkich (REE) w gospodarce światowej: studium przypadku Neodymiun
Authors: SALA Dariusz , BIEDA Bogusław
Published: February 2024

Niniejsze opracowanie stanowi przegląd wykorzystania pierwiastków ziem rzadkich (REE) w gospodarce światowej w oparciu o magnesytrwałe zużywające głównie mieszaninę neodymu (Nd), prazeodymu (Pr) i dysprozu (Dy) oraz ceru (Ce), a także gadolin (Gd)w znacznie mniejszych ilościach. W rzeczywistości segment rynku magnesów jest największym rynkiem metali ziem rzadkich (REM)pod względem wolumenu i nadal będzie osiągał lepsze wyniki niż inne segmenty rynku. W raporcie „Rare Earths, Outlook to 2030”zaprezentowanym podczas Green Car Congress w dniu 3 lutego 2021 r. i opracowanym przez prognozę Roskill Commodity Research,nabytym w czerwcu 2021 r. przez Wood Mackenzie, wiodącą światową firmę zajmującą się badaniami, doradztwem i analityką danych,zasilającą biznes z branży zasobów naturalnych, Roskill prognozuje, że zastosowania magnesów ziem rzadkich będą stanowić~40% całkowitego zapotrzebowania do 2030 r., co zwiększy potencjał ścisłej równowagi podaży i popytu w przypadku kluczowychmagnetycznych REE. Przedstawiono i omówiono podaż pierwiastków ziem rzadkich na rynku USA, Europy, Japonii i Chin.
Sustainable Agriculture Development Program in Changing the Mindset of Farmers in Cikurubuk Village
Authors: Dinn Wahyudin  , Setiadi Edi , Evan Firdaus
Published: February 2024

Cikurubuk Village has invaluable wealth in the form of abundant water springs that are scattered throughout the village area, so that they become a source of life for the people in the Cikurubuk Village area and its surroundings. Based on existing data, Cikurubuk Village has 10 (ten) springs. Gradually farmers are able to change their mindset, so that they do not continue to depend on government subsidised fertilisers which are increasingly difficult to obtain and at high prices by repairing the soil ecosystem that was damaged by the use of synthetic fertilisers and pesticides used over the years. The method used is descriptive analytic, which is a method that focuses on awareness (descriptive) through situations and events that occur in the community related to the object of research, namely the behaviour of the village community when farming organic rice in an effort to local food security. Agricultural cultivation, making Cikurubuk village a role model for other farms that are able to reduce unemployment by producing one superior product developed from the innovation of patani rice from organic agricultural cultivation
Abordagem inicial sobre cuidados paliativos em pacientes com doença renal crônica
Authors: Pontes Milena Rodrigues , Vieira Ana Carollina Duarte , Silva Martina Hilário , Masini Ana Carolina Santiago , Barreto Ana Clara Faria da Cruz , CORREA ANA CLARA FARIA BARCELLOS , Schuabb Andreia Carneiro , Lima Thiago Santos , Tristão Lucas de Paiva Cabral , Oliveira Danieli Ferreira de Lima , Machado Ana Beatriz de Sousa
Published: February 2024

Introdução:
A Organização Mundial de Saúde define os Cuidados Paliativos como uma abordagem que promove a qualidade de vida dos pacientes e seus familiares diante de situações que ameaçam a continuida
O Caminho de Jigoro
Authors: Pinto Andrey Honório G , Moia Arthur Vinicius , Nazaré Rafael Santos de , Adelino Gleidson Siqueira , Borba-Pinheiro Claudio Joaquim
Published: February 2024

Este livro foi idealizado a partir de um trabalho da disciplina fundamentos e métodos das lutas e artes marciais do curso de Educação Física da Universidade do Estado do Pará (UEPA) no campus de Tucuruí. O trabalho, foi o desenvolvimento de livros didáticos curtos que tivessem como tema central as lutas, artes marciais e esportes de combate conhecidos pelos alunos. Utilizou-se para isso, a metodologia da problematização. A tarefa foi encarado pelos alunos com entusiasmo, e o livro “O caminho de Jigoro: passos de um guerreiro” foi desenvolvido por um grupo de alunos sob a orientação do professor. Para a confecção do livro, foi definido em reunião com os alunos a utilização do método conto narrativo de ficção com o uso de diálogos entre a narração, seguidos dos personagens, tipo de narração e narrador, a linguagem, o tempo e o espaço. Diante desta etapa definida, foi discutido o enredo, desenvolvimento, clímax e desfecho do livro. Além disso, foi sugerido pelo professor que alguns personagens da história geral e local do Judô no Estado do Pará fossem contemplados nos personagens, como o sensei Alfredo Coimbra precursor do Judô e Jiu-Jitsu no Pará, a academia Conde Koma Judô Clube, a primeira academia registrada na cidade de Belém, na travessa Vileta e, é claro, o personagem Jigoro em homenagem ao Jigoro Kano, fundador do Judô no Japão. Assim, a história de “Jigoro” foi construída em duas linguagens: a verbal escrita, bem como, a não verbal, isto é, aquela apresentada pelas imagens e figuras, para um melhor entendimento do público-alvo. O diálogo de “O caminho de Jigoro: passos de um guerreiro” é um discurso direto, onde aproxima o leitor dos personagens e também dos sentimentos que o conto narrativo apresenta a todos os leitores. Bem, para saber o final da história de Jigoro, você terá que ler ou pedir para que alguém leia para você. O livro “O caminho de Jigoro: passos de um guerreiro” que retrata o Judô a partir de uma história fictícia de superação e de mudança de hábitos de vida, nos faz lembrar que o esporte de combate pode realçar uma imagem positiva dos bons professores e daqueles que praticam esse esporte.
Lisansüstü Öğrencilerin Akademik Yazma Öz-Yeterliliklerine İlişkin Değerlendirmeleri
Authors: TUNAY GÜL Zeynep , GÜROL Mehmet , ALCI Bülent
Published: February 2024

Akademik yazma becerisi, bireylerin sınavlar, ödevler ve bilimsel araştırma becerileri gibi çeşitli eğitim düzeylerindeki performansını etkilemektedir. Üniversite eğitiminde akademik yazının amacı göz önünde bulundurulduğunda genellikle içerik ve biçim açısından anlatılması gerekenlerin mutlak kurallar ve yollar dikkate alınarak sunulduğu görülmektedir. Akademik ve mesleki başarı için kilit bir parametre olan akademik yazma becerisi, yalnızca kurallara ve kodlara uymayı değil, aynı zamanda görevin karmaşık taleplerini karşılamak için bilişsel becerileri de kapsamaktadır. Öğrencilerin gerek lisansüstü dönemde yürüttükleri ödevlerde gerekse bilimsel çalışmalarında sıklıkla başvurmaları gereken akademik yazma becerilerine sahip olmaları beklendiğinden, bu kritik ancak zorlu beceri yakın zamana kadar araştırma odağında olmamıştır. Bu çalışma, lisansüstü öğrencilerinin akademik yazma konusundaki öz-yeterlilik algılarını derinlemesine incelemeyi hedefleyerek, nitel araştırma yaklaşımlarından fenomenoloji desenini benimsemiştir. Veriler, görüşmeler yoluyla toplanmış ve nitel verilerin analizi için içerik analizi yöntemi kullanılmıştır. Bu doğrultuda, İstanbul’da bulunan bir devlet üniversitesinde öğrenimlerine devam eden 8 lisansüstü öğrenciyle görüşülmüş ve verilerin çözümlenmesi sonucunda 1 temaya ulaşılmıştır. Bu tema altında ise 3 kategori yer almıştır. Bunlar sırasıyla ‘Yeterli Hissedilen Alanlar’, ‘Yetersiz Hissedilen Alanlar’ ve ‘Öneriler’ olarak belirlenmiştir. Çalışma, akademik yazma konusunda karşılaşılan sorunları tespit ederek, öğrencilerin akademik yazımda kendilerini ne kadar güçlü ya da zayıf algıladıklarını ve bu çalışmadan elde edilen görüşler neticesinde yetersiz görülen alanları güçlendirmek için neler yapılabileceğini gösteren anlamlı bir tablo sunmaya çalışmıştır.
One Direction
Authors: Azzopardi Andrew , Catania Gottfried , Grech Paulann
Published: February 2024

This paper draws on the data from the study commissioned by the Faculty for Social Wellbeing (University of Malta) in 2023 called ‘The perceived effect of traffic on our wellbeing amongst the Maltese Population’. It seeks to navigate around the seeming impact of traffic on the populace, in terms of social wellbeing. In this paper, we will be revealing that there are no two ways around this phenomenon. What we will be referring to as the ‘trafficisation’ in our communities is having a major impact on our standard of living. In other words, the commodification of our communities, and car ownership as one of the indicators, is starting to leave an indelible mark on the livability and quality of life of its citizens. The liminality of progress and economic affluence in relation to our quality of life is the tension that will be debated in this epistemological-driven piece of work. The paper will attempt to confer the research question that livability and improved quality of life depend on re-negotiating a lifestyle which is not car-centric.