bluuebunny/crossref_metadata_2025 huggingface dataset:
Interactive Association of Posttraumatic Stress Disorder and Related Comorbidities with Loneliness on Suicidal Thoughts and Behavior in the Army National Guard
Authors: Lawrence Karen A. , Edwards Alice C. , Cerel Julie
Published: January 2024

The public health challenges of suicide include suicidal thoughts and behaviors (STB) such as suicidal ideation and nonfatal suicide attempts. STB precede suicide death in the ideation-to-action framework. To better understand relationships of psychiatric and psychosocial correlates of STB, this study examined associations among PTSD and related co-occurring symptoms of depression and alcohol misuse as well as their interaction with social isolation and loneliness on STB. Three hypotheses were tested in a population-based sample of 1,992 Army National Guard (ANG) members: (1) PTSD, depression, alcohol use symptom severity, and social isolation and loneliness will be associated with STB, (2) PTSD symptom severity score combined with that of depression, alcohol use, and both, will be associated with STB and explain more variation in STB than PTSD symptom severity alone, and (3) the relationship between STB and PTSD symptom severity alone and in combination with co-occurring depression and alcohol use symptom severity will be moderated by social isolation and loneliness. Notably, National Guard members face both similar and distinct stressors compared to active-duty military. Our findings suggest associations between mental health symptom severity and STB in the ANG are similar to those of the larger veteran population. Findings from the interaction analysis suggest that addressing social isolation and loneliness in the context of PTSD may decrease STB and may be especially important when PTSD symptoms are accompanied by co-occurring depressive symptoms or alcohol misuse.
Role of KMT2B and KMT2D histone 3, lysine 4 methyltransferases and DNA oxidation status in circulating breast cancer cells provide insights into cell-autonomous regulation of cancer stem cells
Authors: Ferrer-Diaz Alejandra I. , Sinha Garima , Petryna Andrew , Gonzalez-Bermejo Ruth , Kenfack Yannick , Adetayo Oluwadamilola , Patel Shyam A. , Nehra Anupama-Hood , Rameshwar Pranela
Published: January 2024

Background
Breast cancer cells (BCCs) can remain undetected for decades in dormancy. These quiescent cells are similar to cancer stem cells (CSCs); hence their ability to initiate tertiary metastasis. Dormancy can be regulated by components of the tissue microenvironment such as bone marrow mesenchymal stem cells (MSCs) releasing exosomes to dedifferentiate BCCs into CSCs. The exosomes cargo includes histone 3, lysine 4 (H3K4) methyltransferases, KMT2B and KMT2D. A less studied mechanism of CSC maintenance is the process of cell-autonomous regulation, leading us to examine the roles for KMT2B and KMT2D in sustaining CSCs, and their potential as drug targets.
Methods
Use of pharmacological inhibitor of H3K4 (WDR5-0103), knockdown (KD) of KMT2B or KMT2D in BCCs, real time PCR, western blot, response to chemotherapy. RNA-seq and flow cytometry of blood from BC patient for markers of CSCs and DNA hydroxylases. In vivo studies with a dormancy model for response to chemotherapy.
Results
H3K4 methyltransferases can sustain CSCs, impart chemoresistance, maintain cycling quiescence, and reduce migration and proliferation of BCCs. In vivo studies validated KMT2’s role in dormancy and identified these genes as potential drug targets. DNA methylase (DNMT), predicted within a network with KMT2 to regulate CSCs, was determined to sustain circulating CSC-like in the blood of patients.
Conclusion
CSCs are sustained by H3K4 methyltransferases and DNA methylation. Overall, the findings provide crucial insights into the epigenetic regulatory mechanisms underlying BC dormancy with KMT2B and KMT2D as potential therapeutic targets. We do not propose to change the standard of care, but to monitor circulating BCCs as a functional indicator for targeted treatment to prolong BC remission, which will partly address health disparity.
User Activities Based Trust Management Framework for Online Social Networks
Authors: Sirisala NageswaraRao , Sirisala Srinivasulu
Published: January 2024

The ubiquity of mobile phones and web technology has facilitated continuous communication within Online Social Networks (OSNs) such as Twitter, Instagram, Facebook, and LinkedIn. In OSNs, individuals have the capability to share posts and photos with their relatives and friends, as well as to promote and publicize their businesses. However, this also opens up the potential for malicious users to misuse personal information. Consequently, researchers have turned their attention toward proposing trust-related methods aimed at ensuring a secure environment within social networks. Trust management involves the observation and rating of each user based on his activities, ensuring that only trustworthy users are granted permission to share their activities. In this paper “User Activities Based Trust Management Framework for Online Social Networks-TMFOSN” is proposed. Where users trust values are managed and keep getting updated through the different phases like trust computation, aggregation, propagation, and updations. In TMFOSN, user direct and indirect trust is evaluated with reference of Twitter social network dataset. The performance of TMFOSN is compared with other trust estimation methods, where it is outperformed with increased number of user profiles.
Prelacteal Feeding Practice among Primipara Mothers in Urban Northwest Ethiopia: A Cross-Sectional Study
Authors: Ayalew Tilksew
Published: January 2024

Background: Breast feeding can save millions of lives and billions of dollars each year. It is a promising intervention to achieve Sustainable Development Goals. It makes the world healthier, smarter and more equal. However, sub-optimal infant feeding like prelacteal feeding can hamper these invaluable contributions of breast feeding. Understanding the level and influencing factors of prelacteal feeding among primipara mothers could have important implications to improve infant feeding and shade lights on breast feeding study among this group of population. Therefore, this study aimed to investigate prelacteal feeding practice and its predictors among primipara mothers.
Method: A community- based cross-sectional study was conducted from March 01 to April 30 2016 among (n=398) randomly selected primipara mothers in Bahir Dar city, North West Ethiopia. Data were collected using a structured interviewer-administered questionnaire and analyzed using SPSS version25. Bivariable and multivariable logistic regression analyses were executed to identify influencing factors of prelacteal feeding. Statistical significance for dependent and independent variables association was declared at P-value ≤0.05, and the strength of associations were measured using odds ratio with 95% confidence interval.
Result: The current study revealed that prelacteal feeding was practiced by 15.8 % of primipara mothers. Primipara mothers, who were delivered via normal delivery (aOR=10.6, 95%CI; 1.40-80.9) and who initiated breastfeeding early (aOR=3.73, 9% CI; 1.63-8.58) were less likely to practice prelacteal feeding.
Conclusion: This study revealed that prelacteal feeding is a common practice in the study area. Mode of delivery and timely initiation of breastfeeding were exclusive predictors of prelacteal feeding practice. Consequently, it was recommended that health care providers who work in maternity unity and other stakeholders should discourage unnecessary cesarean deliveries and promote timely initiation of breast feeding to hinder prelacteal feeding practice.
RELM-β knockout inhibits the development of hypoxia-induced pulmonary hypertension through PLC-IP3R-Ca2+ signaling pathway
Authors: Liu Guoyu , Tian Heshen , Liu Yi , Xing Yan , Wu Ying , Liu Lei , Fu Daiyan , Chen Huilian , Zhang Chao , Dai Aiguo
Published: January 2024

Purpose Pulmonary vascular remodeling (PVR) is an important pathological mechanism of hypoxia-induced pulmonary hypertension (HPH), in which the proliferation of pulmonary artery smooth muscle cells (PASMCs) plays an important role. Resistin-like molecule beta (RELM-β), a secretory protein, can promote the proliferation of PASMCs induced by hypoxia. As an important signaling molecule, Ca2+ plays an important role in cell proliferation. RELM-β can regulate cell proliferation by changing the intracellular calcium concentration ([Ca2+]i), but the specific regulatory mechanism of RELM-β on Ca2+ and the pathogenesis of HPH has not been fully elucidated.
Methods We employed both in vivo and in vitro RELM-β knockout (RELM-β-/-) models to examine the effects of RELM-β on pulmonary hemodynamics, PASMCs proliferation, intracellular Ca2+ release, and associated mechanisms.
Results The expression of RELM-β increased in rat HPH model and hypoxia treated PASMCs, which led to pulmonary hemodynamic changes (increased mean pulmonary artery pressure (mPAP), right ventricular hypertrophy, pulmonary artery thickening) and PASMCs proliferation. However, knockout of RELM-β had the opposite effect. RELM-β deletion decreased the expression of phospholipase C (PLC), inositol 1,4,5-trisphosphate (IP3) receptor (IP3R), and [Ca2+]i. In addition, inhibition of PLC and IP3R can reduce [Ca2+]i.
Conclusion Our research results have confirmed the role of RELM-β as a cytokine-like growth factor in the proliferation of PASMCs and contribute to HPH. This was achieved by upregulating [Ca2+]i through the PLC/IP3R pathway.
Identification of lysosome-related genes in gastric cancer and development of a prognostic model
Authors: Wei Zihao , Wang Zhengrui , Chen Zi , Luo Dongmei
Published: January 2024

Background
Despite significant advancements in the diagnosis and treatment of gastric cancer (GC), it remains a major contributor to global cancer-related mortality, characterized by high rates of distant recurrence and late-stage fatality.
Methods
We obtained gene expression data for the GC cohort (TCGA-STAD) from the Genomic Data Public Portal (GDC) and lysosome-related genomic data from AMIGO. We used the GSE66259 dataset from the Gene Expression Omnibus (GEO) database for external validation. Initially, we screened GC tissues for differentially expressed genes (DEGs) compared to normal tissues and overlapped DEGs with lysosomal genes to obtain lysosome-related genes (LRGs). Key LRGs were then selected for prognostic modeling through univariate Cox regression, Least Absolute Shrinkage and Selection Operator (LASSO) regression, and multivariate Cox stepwise regression. The prognostic models were evaluated using Kaplan-Meyer (K-M) analysis and receiver operating characteristic (ROC) curves. Independent prognostic factors were also identified by univariate Cox regression and multivariate Cox regression analyses. Additionally, we investigated biological functions, response to immune checkpoint inhibitors (ICIs), as well as tumor mutational load (TMB) mutations in high- and low-risk groups.
Results
The Univariate Cox analysis identified a total of 48 lysosomal genes with significant differential expression. Subsequently, LASSO regression was employed to select 11 prognostic genes. Finally, a multivariate Cox stepwise regression yielded a set of 7 genes (TRIM29, EGF, GPC3, RETN, RNASE3, GRP, and PSAL1) for constructing the prognostic models. The validated risk model demonstrated accurate prediction of clinical outcomes. Furthermore, independent prognostic analyses revealed that the risk score along with stage and age were independent prognostic factors. Notably, significant differences in biological function, immune microenvironment characteristics, as well as immunotherapy response, were observed between the high- and low-risk groups.
Conclusions
The identification of 7 key prognostic LRGs associated with GC patients facilitates accurate prognosis prediction and presents a novel avenue for enhancing clinical management and prognostic outcomes in the GC patient population.
Assessment of using radial probe endobronchial ultrasound with a guide sheath to increase the yield rate of transbronchial biopsy: A prospective randomized trial
Authors: Chang Hao-Chun , Kuo Yao-Wen , Lin Ching-Kai , Chang Lih-Chyun , Chen You-Yi , Yang Ching-Yao , Chien Jun-Yen , Hsu Chia-Lin , Tsai Tzu-Hsiu , Ho Chao-Chi , Shih Jin-Yuan , Yu Chong-Jen
Published: January 2024

Background
Radial probe endobronchial ultrasound (rEBUS)-guided transbronchial biopsy (TBB) with a guide sheath (GS) is widely used to diagnose peripheral lung lesions (PPLs), but there is no consensus on whether it increases the diagnostic yield. We conducted this prospective study to compare the diagnostic yield of the GS method to the conventional method without a GS.
Material and methods
From November 2019 to March 2023, patients with PPLs were recruited and randomly assigned to rEBUS-TBB with a GS (GS group) or without a GS (conventional group). The histopathology, cytology, and microbiology yield rates, as well as procedure time and post-procedure adverse events of the two groups were compared.
Results
A total of 102 patients were enrolled (54 in the GS group and 48 in the conventional group). The GS group exhibited a trend of increased pathology yield (75.9% vs. 68.8%, p = 0.418), while the yield rates of brushing cytology (64.3% vs. 42.9%, p = 0.030) and washing cytology (41.5% vs. 20.0%, p = 0.0443) were higher in the GS group. Meanwhile, the yield from GS washing culture was lower than the bronchial washing culture yield (0% vs. 57.1%, p = 0.017). The bleeding risk was also lower in the GS group (9.3% vs. 20.8%, p = 0.049), but the procedure time was longer in the GS group (17.6 ± 4.7 min vs. 15.1 ± 4.5 min, p = 0.008).
Conclusion
rEBUS TBB with a GS can increase the diagnostic yield of PPLs and decrease the risk of bleeding, while additional bronchial washing should be utilized to increase the microbiology yield.
Trial registration:
The study was registered at Clinicaltrials.gov (NCT04056273).
Comparative proximate Analysis of Citrullus collocynthis(melon) and Prosopis africana(mesquite)
Authors: Ogbu J.C. , Nwosu P.C.
Published: January 2024

It is necessary to compare the nutrient quality before and after fermentation, to know the influence of fermentation on processed food. This research compares the nutrient composition before and after fermentation of Citrullus colocynthis and Prosopis Africana.2007). The Proximate composition (The moisture content, Ash content, Fibre content and lipid content) of the different samples was determined (Fermented Citrullus collocynthis in foil and Unfermented Prospis africana had highest moisture content of 83.0 and 62.1 respectively, Fermented Prosopis africana in Nylon and Unfermented Citrullus collocynthishad the highest Ash content of 1.20 and 0.67 respectively, Fermented Prosopis africana in foil and Fermented Citrullus collocynthis in foil had the highest fibre content of 40.18 and 12.80 respectively, Fermented Prosopis africana in foil and Unfermented Citrullus collocynthis had the highest fat content of 2.00 and 30.00 respectively.
Isolation, Identification and Antibiogram Activity of Bacteria From Urinary Tract Infected Women
Authors: Abubakar S.
Published: January 2024

This research shows that that 15 out of 30 samples collected and screened for UTI yielded positive bacterial culture. Gram negative bacteria (Salmonella typhii 13(86.7)% and Klebsiella spp 2(13.3)%) was observed to be the major bacteria in this study and they were almost sensitive to ciprofloxacin and tarivid.
Impact of Covid-19 Pandemic Lockdown on temporal variation of air quality in Bengaluru City – A case study
Authors: SRINIV ULLAS , B Prathima
Published: January 2024

The current study examines the variation in air pollution in Bengaluru, India, considering the influence of the Covid-19 lockdown. The concentration of 8 air pollutants including Particulate matter, and air quality index (AQI) is analysed. A geospatial analysis is performed using QGIS software, to depict pollution variation, based on which, further a relative change in concentration of each pollutant and AQI is determined. Exceedance factor (EF) of pollutants from 2019 to 2022 is determined along with statistical correlation analysis.
The lockdown was implemented in March 2020, followed by a series of uplifting, and imposing, the months of March, April, and May were chosen for analysing. The study discovered a maximum reduction in AQI of (58%). However, a significant rise is observed, post-lockdown in 2022. The EF results revealed that particulate matter PM10, PM2.5 and NO2 are the major pollutants that posed a serious threat, as few stations fell into the 'Critical’, pollution category, especially in 2019. During the research period, SO2, C6H6, and NH3 concentrations were below the prescribed levels. The correlation study revealed that the AQI was closely related to PM10 and PM2.5. Overall, PM10, surpassed acceptable norms and is a principal criterion pollutant responsible for AQI in Bengaluru.
WaterScope: A Versatile Open-Source Platform Enabling Smart, Simple, Water Testing - for All
Authors: Mahdi Sammy , Dabrowska Alicja , Lewis George , Atlabachew Minaleshewa , Salter Susannah , Henderson Cassi , Ji Chang , Ehlers Annike , Stirling Julian , Mower Sophie , Allen Lara , Lay Elizabeth , Stuart Kara , Appavou Lisa , Bowman Richard , Zhao Tianheng , Patel Nalin , Patto Alexander , Holmes Mark , Baumberg Jeremy
Published: January 2024

Increasing access to water quality tests in low-income communities is a crucial strategy toward achieving global water equality. Recent studies in the Water Sanitation and Hygiene (WASH) sector underscore the importance of addressing practical concerns in water testing, such as robustness and results communication. In response, we present the WaterScope testing kit; an open-source, novel platform for drinking water quality assessment. It modernises the testing process with the inclusion of a unique cartridge/slider mechanism, machine-learning-enhanced classification and full digitalisation of results. WaterScope’s equivalency to conventional methods for quantifying E. coli is established through extensive validation experiments in both laboratory and field environments. This versatile platform provides potential to expand its applications to test other bacteria, perform colorimetric assays, and analyse clinical samples such as blood/urine samples. We anticipate that the system’s ease-of-use, portability, affordability, robustness, and digital nature will accelerate progress toward global water equality.
Harmony Amidst Chaos_ Decoding Coping Skills and Unraveling Anxiety and Depression Dynamics in the Wake of the COVID-19 Pandemic
Authors: Moment Lauren
Published: January 2024

This comprehensive analysis conducted during the COVID-19 pandemic investigates the intricate relationships between coping strategies and anxiety and depression levels, presenting crucial implications for medical, clinical, and broader societal settings. The findings reveal nuanced relationships between specific coping mechanisms and anxiety and depression, offering clinicians and laypeople valuable insights for tailoring interventions. Strategies such as emotional support emerge as pivotal in mitigating anxiety and depression, while others, like self-blame and excessive planning, show associations with increased symptomatology. The implications extend to catastrophic events and other major life disruptions, emphasizing the need to address maladaptive coping during crises. The abstract underscores the importance of individualized approaches, integrating these insights into therapeutic dialogues for enhanced mental well-being. Awareness campaigns are advocated for societal resilience, emphasizing effective coping strategies.
Exploring the Interplay of Mutations, Viral Stability, and Implications for Innovative Vaccination Strategies and Therapeutic Approaches Among Various SARS-CoV-2 Variants
Authors: Abduljaleel Zainularifeen
Published: January 2024

This study explores the infectivity of SARS-CoV-2 and its implications for immune evasion, resulting in significant variants carrying mutations that facilitate evasion from host cells. As global vaccination initiatives progress, our research comprehensively analyzes viral evolution, variants, and immune evasion strategies. Focused on fourteen key epitope mutations (Arg346Lys, Lys417Asp, Leu452Glu, Leu452Arg, Phe456Leu, Ser477Asp, Thr478Lys, Glu484Ala, Glu484Lys, Glu484Gln, Gln493Arg, Gly496Ser, Glu498Arg, and His655Y) within the spike protein's Receptor-Binding Domain (S-RBD), we unveil consistent patterns associated with immune escape in various SARS-CoV-2 variants. Our findings highlight the influence of protein fold stability, hACE2 binding, and antibody evasion on spike protein evolution. The results confirm that single-point immune escape variants alter virus stability, impacting the success of the antibody response. By correlating expression levels and thermodynamic stability for each mutant, we gain insights into the functional characteristics of the spike protein. This research provides valuable contributions to understanding immune escape variants, specifically targeting mutations within the receptor-binding domain. It suggests promising avenues for enhancing vaccine efficacy amidst the dynamic SARS-CoV-2 variant landscape. Overall, our study not only broadens the horizons for innovative vaccination strategies but also paves the way for novel therapeutic approaches in SARS-CoV-2 variants.
Projectile motion in a medium with quadratic drag at wind influence
Authors: Chudinov Peter
Published: January 2024

A classic problem of the motion of a projectile thrown at an angle to the horizon is studied. Air resistance force is taken into account with the use of the quadratic resistance law. The action of the wind is also taken into account, which is considered constant (tailwind or headwind). The wind speed vector contains horizontal and vertical components. The projectile velocity hodograph equation is used to take into account the effect of wind. Comparatively simple analytical approximations are proposed for the main variables of motion (cartesian projectile coordinates and time). All obtained formulas contain only elementary functions. The proposed formulas are universal, that is, they can be used for any initial conditions of throwing. In addition, they have acceptable accuracy over a wide range of the change of parameters. These formulas make it possible to solve a variety of model problems of projectile motion without the use of numerical integration. The motion of a tennis ball and shuttlecock of badminton are presented as examples. The calculation results show good agreement between the proposed analytical solutions and numerical solutions. The proposed analytical formulas can be useful for all researchers of this classical problem.
Adaptive Sampling Immune Algorithm for Multi-Objective Probabilistic Optimization
Authors: Zhang Renchong , Pan Chunyan , Zhang Renmao
Published: January 2024

In this paper, for a general type of multi-objective probabilistic optimization problem without any prior noisy information, which has an extensive engineering application background and needs to be solved urgently, we propose a small-population immune algorithm with adaptive sampling to solve. In the design. First, we design a small-population immune algorithm framework inspired by the response mechanism of adaptive immunity. Second, we design an adaptive sampling scheme that adaptively allocates an appropriate number of samples for each sub-objective function of all individuals in the population to estimate the objective function value. Third, based on the objective function estimates, the dominance levels of all individuals in the population and the crowding distances of individuals in each dominance level are determined. Fourth, the clone size, mutation rate, crossover distribution index, and mutation distribution index of an individual are designed to be adaptively determined based on the number of iterations, dominance level, and crowding distance. Cloning, crossover, and mutation operators are implemented for each individual, using simulated binary crossover and polynomial mutation to enhance co-evolution and facilitate information sharing and exchange among all individuals. Fifth, based on the dominance level and crowding distance, the population update strategies are designed to adaptively update the memory set with high-quality individuals and generate a new generation population with good diversity. Finally, based on three theoretical problems and two engineering problems, as well as six representative comparative algorithms, the experimental results show that the proposed algorithm is an optimizer with good competitiveness and application potential, and has few parameters, less sample consumption, strong noise suppression ability, and high search efficiency.
Professional networks for research and practice change in Allied Health professions in public health
Authors: Hitch Danielle , Clapham Renee , Pinson Jo-Anne , Sayner Alesha , Shannon Michelle , King Olivia , Snowdon David , Macdonald Emma , Greco Marnie , Boyce Rosalie , Dennett Amy , Howlett Owen , Klaic Marlena , Borschmann Karen , Withiel Toni , Schneider Michal
Published: January 2024

This study aimed to describe professional networks relating to the research and practice change activities of allied health professionals (AHPs) within the public healthcare system of Victoria, Australia. Using a mixed methods cross-sectional approach, survey data were collected from 299 AHPs in metropolitan, regional and rural healthcare services. AHPs are mostly not engaged with research and practice change networks, with less than half (n=123, 41%) identifying key contacts for either activity. Participants’ key contacts in professional networks were typically from the same discipline, healthcare service and local area, although networking for practice change involved more contacts from other disciplines and workplaces compared to research networks. Most contacts (86%) were related to either research or practice change only, suggesting largely separate networks. Collaboration drives research and practice change networks, with research contacts often arising from formal research collaborations that provided opportunities for individual research participation and skill development. In contrast, practice change contacts facilitated discussion of ideas, relationships with clinical teams, and workforce development activities. The limited diversity in professional networks may be a barrier to multidisciplinary research and practice change. Better collaboration between different types of professional networks may help close the ‘research to practice’ gap.
Studies on Diversity of Spider at Hadapsar, Pune
Authors: choure Prachi Devidas , Basate Swapnil Somnath , Patil Archana Hemant
Published: January 2024

Insects, which comprise the largest taxonomic group in the animal kingdom, hold immense ecological significance. Biodiversity encompasses the collective presence of various populations, species, and communities within specific areas. Among these, spiders play a crucial role as they primarily act as predators, playing a pivotal role in maintaining the balance of insect populations in environment. With a wide range of species, spiders are considered key components of all ecosystems, serving as an important indicator of overall species abundance and terrestrial ecosystem health. However, despite their relevance, a comprehensive study on spider diversity in Pune, Maharashtra, India remains partial. Consequently, our current study aims to fill this gap by providing valuable insights and pertinent information regarding spiders. The research was conducted during December 2022 and April 2023, encompassing various locations such as houses, gardens, warehouse, farms and libraries within the Hadapsar area which is in Located Pune district.
Application of γ-Nanoalumina-based Kaolinitic Clay (Na-Kc) in the Adsorptive Removal of Basic Blue 9 from aqueous synthetic Solution
Authors: Tchanang Gustave , Kepdieu Jean Marie , Djangang Chantale Njiomou , Ekani Cyprien Joel , Baldé Mamadou Yaya , Abi Charles Fon , Blanchart Phillipe
Published: January 2024

Experimental and theoretical investigations related to the adsorptive removal of Basic blue 9 (BB9) onto γ-nanoAl2O3 have been done in the present work. Batch tests were carried out varying some processing parameters namely initial dye concentration (5 - 50 mg/L), adsorbent dose (0.5 - 5 g/L), initial pH (1 - 12) and contact time (0 - 30 min). Under conditions of C0 = 50 mg/L; pH = 11; dose = 1g/L and t = 15 min, more than 83.6% of the BB9 molecules were removed. The pseudo-second order and the Langmuir models fit well the experimental data with highest R2 values of 0.99 and 0.91 respectively and lowest values of χ2. This suggests a two- step mechanism on a homogeneous distribution of active sites on the adsorbent surface. The adsorption mechanism first involved electrostatic interactions between the negatively charged γ-nanoAl2O3 surface in basic medium and secondly electrophilic-nucleophilic interactions. Compared to other adsorbents, γ-nanoAl2O3 of this work is a good alternative for treatment water containing dye BB9.
Machine learning-based bioinformatics analysis of common hub genes associated with oxidative stress and immune infiltration in COPD and atherosclerosis
Authors: Quan Jinhai , Fan Weijie , Li Shisen , Xie Huaijin , Li Shanghai , Huang Ruina , Liang Weijun
Published: January 2024

Background
Chronic obstructive pulmonary disease (COPD) and atherosclerosis (AS) are both chronic irreversible diseases in the aged population, with oxidative stress (OS) and immune activation as the pathological basis. This study explored the common hub gene associated with OS and immune cell infiltration in AS and COPD.
Methods
Genes associated with AS were identified by the differentially expressed genes (DEGs) analysis and weighted gene co‑expression network analysis (WGCNA) in the GSE100927 dataset. Genes associated with COPD were analyzed by WGCNA in the GSE76925 dataset. Functional enrichment analysis was carried out by Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). The common hub OS-related genes were analyzed by the intersection of the WGCNA modules of AS and COPD and OS‑related genes, protein–protein interaction (PPI), and lasso regression. The diagnostic value of the hub common genes was assessed by receiver operating characteristic analysis. The association of the hub common genes with immune infiltration in AS and COPD was analyzed by the Spearman correlation method.
Results
A total of 455 DEGs (336 upregulated genes and 139 downregulated genes) were identified in GSE100927. The turquoise module of WGCNA in GSE100927 and the yellow module of WGCNA in GSE76925, which are the most relevant modules, were intersected and obtained 25 common OS-related genes between AS and COPD. Those common OS-related genes were enriched in signaling pathways related to immunity and OS. Two hub common OS-related genes (SELL and MMP9) were identified and showed good diagnostic value in AS and COPD. The Spearman correlation analysis showed that the hub common OS-related genes positively or negatively correlated with various infiltrating immune cells.
Conclusion
Our study identified the common hub genes (SELL and MMP9) associated with OS and immune infiltration in AS and COPD, providing candidate therapeutic targets for AS combined with COPD.
Unsupervised Subdomain Adaptation Robust to Noisy Pseudo Labels Using Symmetric Loss
Authors: Li Yundong , Yan Yunlong
Published: January 2024

Alignment of subdomain distribution plays an important role in preventing negative transfer in domain adaptation. Due to the lack of labeled data in the target domain, the current mainstream methods prefer using pseudo labels to align the features of corresponding categories between the source and the target domains. However, the noises present in pseudo labels affect the effectiveness of subdomain alignment. In the community of domain adaptation, samples with higher confidences are believed to be more reliable when generating pseudo labels. However, we found that this conclusion does not hold for hard samples. To address this issue, we propose a pseudo label screening mechanism which considers the trade-off of quantity and quality. The qualified target samples participate in the subdomain adaptation, while the unqualified samples are randomly assigned with labels. Thus, the asymmetric noises of hard samples are converted into symmetric noises. Symmetric loss is proved to be robust to symmetric noises. Inspired by this observation, we propose a symmetric subdomain adaptation loss (SSAL) and construct a robust subdomain adaptation network (RSAN) based on SSAL accordingly. Leveraging the random label assignments of hard samples and SSAL, we reconstruct the relation between sample’s confidence and the probability being correctly classified. The effectiveness of our method has been validated on public benchmarks. Compared with the SOTA method, our RSAN obtains an improvement of 2.7% in terms of average accuracy on the challenging VisDA-2017 transfer task.
Untersuchung zur Sicherheit bei der simultan bilateralen Cochlea-Implantation bei Erwachsenen
Authors:   , Gröger Maximilian
Published: January 2024

Schwerhörigkeit ist sowohl für die betroffenen Patienten als auch sozioökonomisch eine relevante Erkrankung. Sie stellt ein Hindernis für die soziale Teilhabe dar, reduziert die Lebensqualität und führt zu direkten und indirekten Gesundheitskosten. Cochlea-Implantate sind vielkanalige Neuroprothesen, die über einen chirurgisch in die Hörschnecke eingebrachten Elektrodenträger das erste Neuron der Hörbahn direkt elektrisch stimulieren und so eine Hörwahrnehmung induzieren. Dadurch kann ein Funktionsverlust der Haarzellen, welcher die häufigste Ursache für eine Schwerhörigkeit ist, ersetzt werden. Cochlea-Implantate stellen den Goldstandard der Hörrehabilitation bei hochgradig schwerhörigen oder postlingual ertaubten erwachsenen Patienten sowie in der Versorgung prälingual ertaubter Kinder dar. Bei vielen schwerhörigen Patienten besteht die Indikation zur beidseitigen Versorgung mit einem Cochlea-Implantat. Prinzipiell besteht die Möglichkeit, diese chirurgische Versorgung beidseits einzeitig (simultan) oder zweizeitig (sequenziell) durchzuführen. Während die Sicherheit der bilateral-simultanen Operation für Kinder durch mehrere Studien belegt wurde, liegen für Erwachsene erst wenige Daten vor. Die vorliegende Studie untersucht, ob die bilaterale simultane Implantation mit höheren Komplikationsraten als die sequenzielle Operation assoziiert ist und leistet damit einen Beitrag zur Entscheidungsfindung von Patienten und Behandlern. Es konnten 169 zwischen 2008 und 2017 bilateral implantierte Patienten eingeschlossen werden. Davon wurden 34 simultan (Gruppe 1) und 135 (Gruppe 2) sequenziell versorgt. Es wurde die Dauer der Operation, das Auftreten von Minor- und Major-Komplikationen sowie die Dauer des stationären Aufenthalts erfasst und zwischen beiden Gruppen verglichen. Die Ergebnisse zeigten, dass die Gesamtzeit der Patienten im Operationssaal in der simultan implantierten Gruppe deutlich kürzer war. Die Häufigkeit chirurgischer Major- und Minor-Komplikationen unterschied sich hingegen nicht signifikant. Bezüglich einer letalen nicht-chirurgischen Komplikation in der simultan implantierten Gruppe erfolgte eine umfangreiche Aufarbeitung, ohne dass ein kausaler Zusammenhang mit der gewählten Behandlungsmethode nachgewiesen werden konnte. Die Dauer des Krankenhausaufenthalts war in der simultanen Gruppe 0,7 Tage länger als bei unilateraler Implantation, aber 2,8 Tage kürzer als bei beiden sequenziellen Operation zusammen. In der Zusammenschau aller berücksichtigten Komplikationen und der komplikationsrelevanten Faktoren ist die Sicherheit der simultan bilateralen Operation gegenüber dem sequenziellen Vorgehen als gleichwertig zu bewerten. Jedoch muss individuell auf mögliche Risikokonstellationen des Patienten eingegangen werden, die bei der längeren Operationszeit der simultanen Implantation relevant sein kann. Daher ist eine sorgfältige Auswahl der Patienten unter besonderer Berücksichtigung bestehender Komorbiditäten unerlässlich.
MAGNETORESISTANCE SERIE DUNE PHOTOPILE AU SILICIUM A JONCTIONS VERTICALES CONNECTEES EN PARALLELE EN REGIME STATIQUE SOUS ECLAIREMENT POLYCHROMATIQUE
Authors:   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal., I. Ngom Moussa , Lemine Cheikh Mohamed ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal., Lemrabott Habiboula ,   Ecole Superieure Mutinational de Telecommunication-Dakar, Senegal., Gueye Sega ,   Faculte des Sciences et Technologies de leducation et de la Formation-Departement de Physique et Chimie, Universite Cheikh Anta DIOP, Dakar-Senegal., Thiame Moustapha ,   Universite Assane SECK, Ziguinchor, Senegal., Sissoko Gregoire ,   Groupe International de Recherche en Energie Renouvelable (GIRER). BP. 15003, Dakar, Senegal.
Published: January 2024

Une etude theorique de la photopile au silicium polycristallin a jonction verticale parallele en regime statique sous eclairement polychromatique et sous champ magnetique est presentee. La resolution de lequation de magneto-transport relative a la densite des porteurs minoritaires dans la base a permis de deduire les expressions de la phototension, et de la resistance serie de la photopile en fonction de la vitesse de recombinaison des porteurs minoritaires de charge a la jonction et de la profondeur z de la photopile pour differentes valeurs du champ magnetique. A partir du profil de variation de la phototension en fonction de la vitesse de recombinaison des porteurs minoritaires de charge a la jonction, la methode graphique de determination de la vitesse de recombinaison a la jonction limitant le circuit-ouvert est appliquee. La determination de ce parametre phenomenologique a permis de deduire graphiquement la valeur de la resistance serie pour differentes valeurs du champ magnetique.
SCREENING RICE HYBRID GENOTYPES FOR BLAST AND BROWN SPOT DISEASES RESISTANCE AND YIELD PERFORMANCE
Authors:   Institut des Sciences de lEnvironnement et du Developpement Rural, Universite de Dedougou. BP 176Dedougou. Burkina Faso., Zongo Adama , K. Konate Abdourasmane ,   Centre National de Recherche Scientifique et Technologique (CNRST), Institut de lEnvironnement et de Recherches Agricoles (INERA).01 BP 910 Bobo-Dioulasso 01. Burkina Faso., Kone Soumana ,   Centre National de Recherche Scientifique et Technologique (CNRST), Institut de lEnvironnement et de Recherches Agricoles (INERA).01 BP 910 Bobo-Dioulasso 01. Burkina Faso.,   Universite Joseph Ki Zerbo, Ecole Doctorale Sciences et technologies. Laboratoire Biosciences. Equipe, Genetique et Amelioration des Plantes (EGAP), Ouagadougou. 03 BP 7021 Ouagadougou 03, Burkina Faso., M.N Ouedraogo Arnaud ,   Institut des Sciences de lEnvironnement et du Developpement Rural, Universite de Dedougou. BP 176Dedougou. Burkina Faso.,   Centre National de Recherche Scientifique et Technologique (CNRST), Institut de lEnvironnement et de Recherches Agricoles (INERA).01 BP 910 Bobo-Dioulasso 01. Burkina Faso., Sawadogo Mahamadou ,   Universite Joseph Ki Zerbo, Ecole Doctorale Sciences et technologies. Laboratoire Biosciences. Equipe, Genetique et Amelioration des Plantes (EGAP), Ouagadougou. 03 BP 7021 Ouagadougou 03, Burkina Faso.
Published: January 2024

Rice occupies a prominent place among the cereals produced in Burkina Faso. However, its production faces constraints that impact the performance of the varieties developed. The aim of the present study was to evaluate new hybrid rice varieties with regard to their resistance to blast and brown spot diseasesand their agronomic performances. The plant material consisted of 9 rice varieties, including 04 local controls. Trials were set up in a Fisher block design with 03 replicates at Bama, Banfora and Sindou sites over a two-year study period. Data were collected on the severity and incidence of blast and brown spot disease, as well as on agronomic parameters. The study showed that hybrids were the most resistant to blast and brown spot disease. In addition, maturity was later at the Sindou site than at the other two sites. The WDR1517, WDR73 and WDR737 hybrids were the latest to reach semi-maturity, with cycles ranging from 120 to 132 days. However, hybrids WDR3015 and WDR306 performed better agronomically, with yields of over 9,000 kg/ha on all sites. Yield stability analysis showed that hybrid WDR73 was the most stable of the varieties, with an average yield of 8310 kg/ha. The three-dimensional analysis also proved that these varieties would adapt to our countrys 03 agro-ecological areas.
A STUDY TO ASSESS THE KNOWLEDGE ON URINARY TRACT INFECTION REGARDING ITS PREVENTION AND MANAGEMENT AMONG THE 1ST YEAR B.SC NURSING AT SMT. NAGARATHNAMMA COLLEGE OF NURSING, BENGALURU
Authors:   Professor and Principal of Smtnagarathnamma College of Nursing., Nanjappan Devi , K.M. Geeta ,   Guide and Lecturer Dept.of Obstetrics of Gynecological Nursing., a Aktarazad ,   Final Year Bsc Nursing Students., Babu Alby ,   Final Year Bsc Nursing Students., Chaurasiya Aarti ,   Final Year Bsc Nursing Students., Kumar Shah Anjali ,   Final Year Bsc Nursing Students., Pal Aishi ,   Final Year Bsc Nursing Students.
Published: January 2024

Good health is the fundamental right of every human being and it is essential to lead a successful life. The preamble to the WHO constitution also affirms that it is one of the fundamental rights of every human being is to enjoy The highest attainable standards of health. Moreover, emphasis is based on health promotion andpreventivehealthcare.Goodphysicalandmentalhealthofchildrenandadolescentsmakesforgoodhealth in adulthood. Agreeably, adolescence is a transitional period from dependent childhood to independent adulthood,thatis,agegroupfrom10-19years.Aboutone-fifthofIndiaspopulationisintheadolescenceage group and this is the earliest age where we can prevent morbidity in later life by means of health. According to 2022Ã¢Â€Â“2023-year statical data, the human body gets rid of liquid waste products through the urinary system, and so, it is important to protect this system from infections. Urinary tract infections are the secondmostcommonbacterialdiseasewhichaccountsformorethaneightmillionofficevisitsperyear.More than one lakh (1,00,000) people are hospitalized annually because of urinary tract infection and it is an importantcauseofmorbidityandmortalityinIndiansubjects.Youngageandfemalesexarethetwoimportant factors that contributes to the development of urinary tract infection and therefore it is the most common infection among adolescent girls, which distresses them, concerns their parents, and may cause permanent kidney damage, if there is any delay in treatment. According to the National Institute of Health and Clinical Excellence guidelines urinary tract infection is defined by a combination of clinical symptoms of urinary tract infection that usually include frequency, dysuria, pyuria, abdominal pain, back pain, fever, or urgency. Most urinary tract infections result from ascending infection by single gram-negative bacteria such as Escherichia coli, Klebsiella, Proteus, Enterobacter,orPseudomonas.Staphylococcalinfections,especiallyduetostaphylococcalsaprophyticus are common cause of urinary tract infection among adolescent girls. The two broad categories of urinary tract infectionarepyelonephritisorupperurinarytractinfectionandcystitisorlowerurinarytractinfection.Lower urinary tract infections are common among adolescent girls.
A STUDY TO ASSESS THE KNOWLEDGE ABOUT MENSTRUAL CUP ITS ACCEPTIBILITY, SAFETY, LEAKEAGE AND AVAILABILITY AMONG THE TEENAGE GIRL AND THEIR MOTHER IN A PARTICULAR RURAL AREA IN BENGALURU
Authors: Nanjappan Devi , a Ashwini , Debnath Banasharee , Ghosh Ariti , Barman Arun , P.S Avani , Bagchi Arunkrishna , Biswas Barsha
Published: January 2024

Background: Menstruation is also known as menses or period or monthly discharge of blood and mucosal tissue from the inner lining of uterus through vagina. The first menstrual period usually occurs between 12-15 years of age, called as Menarche. The typical length of time between the first day of one period and the first day of next period is 21-45 days in young women 21-31 days in adults (an average of 28 days). Bleeding usually lasts around 2 to 7 days.Feminine hygiene products are personal care products used during vaginal discharge, and other bodily functions related to the vulva and vagina. Products that are used during menstruation may also be called menstrual hygiene products, including menstrual pads, tampons, menstrual pads, period panties etc. Feminine hygiene products also include products meant to cleanse the vulva or vagina, such as douches, feminine wipes, and soap.Feminine hygiene products are either disposable or reusable. Sanitary napkins, tampons, and pantyliners are disposable feminine hygiene products. Menstrual cups, cloth menstrual pads,period panties, and sponges are reusable feminine hygiene products.Menstrual cup is a device made up of silicon for menstrual hygiene. Despite its being safe, eco-friendly, cheap, and durable its non-acceptability may be due to higher adoption barriers.We conducted this study to assess the acceptability and safety of menstrual cups. Methods: Post-test design and evaluative approach was adopted. Purposive sampling technique was used to select the sample of 60 of teenage and mothers for a period of seven days for data collection. Multiple choice questions, close ended questionnaire and planned teaching programme were used as a tool to assess the knowledge on menstrual cups. The data obtained were analysed in terms of the objectives and it was calculated and tabulated Results: The overall findings are that study shows the majority respondents 30 (76.9%) did not have knowledge regarding menstrual cup and 9 (23.1%) did have knowledge about menstrual cup. Conclusion: The study shows that the respondents had inadequate knowledge regarding menstrual cup. There is a significant increase in post-test scores after the planned teaching programme about menstrual cup and menstrual hygiene.
OZONE A NOVEL INTERVENTION IN PERIODONTAL THERAPY - AN OVERVIEW
Authors:   Post Graduate Student, Department Of Periodontology, Faculty Of Dental Sciences, King Georges Medical University, Uttar Pradesh, Lucknow., Ismail Hira , Kumar Pathak Anjani ,   Professor (Junior Grade), Department Of Periodontology, Faculty Of Dental Sciences, King Georges Medical University, Uttar Pradesh, Lucknow., Lal Nand ,   Professor And Head, Department Of Periodontology, Faculty Of Dental Sciences, King Georges Medical University, Uttar Pradesh, Lucknow., Aamir Khan Mohd. ,   Post Graduate Student, Department Of Periodontology, Faculty Of Dental Sciences, King Georges Medical University, Uttar Pradesh, Lucknow.
Published: January 2024

Ozone has antimicrobial, immuno-stimulatory, anti-hypoxic, bioenergetic, and biosynthetic properties. It is inexpensive, minimally invasive and lacks adverse effects. It is a powerful tool for treating bacterial, fungal, and viral infections, as well as age-related macular degeneration, ischemic disorders, ocular disorders, orthopaedic diseases, haematological diseases, neurodegenerative diseases, pulmonary diseases, renal diseases, dermatological diseases and periodontal diseases. The use of ozone is well indicated in all stages of gingival and periodontal diseases because of its beneficial biological effects, its anti-microbial activity, and its healing and tissue regeneration properties. The effects of ozone treatment in any form (gaseous, water, or oil) have been investigated and analysed with potential exceptional results in the management of periodontal diseases. This review article outlines the clinical applications of ozone therapy in periodontal diseases.