bluuebunny/crossref_metadata_2025 huggingface dataset:
Freedom that is not Absolute: Ecological Ethics and Human-Nature Relationship in the Qur'an
Authors: Muhammad Muhammad , Nurul Yaqin M. Zubad , Reza Mahfud Fakhris Khusnu , Alahmadi Fahd Mohana S
Published: July 2024

This article presents an analysis of ecological ethics in the holy scripture of Islam through the intellectual interpretations of Muslim scholars. The primary focus is on discussing the limitations of human rights in utilizing ecology and the obligation to preserve it according to the perspective of the Qur'an. This discussion is particularly relevant for Indonesia, a country with a majority Muslim population, which is experiencing increasing ecological degradation. The article urges Muslims in Indonesia to refer back to the ecological principles within Islam, avoiding capitalist ideologies that contradict Islamic teachings. The research methodology used is literature analysis, drawing from the texts of the Qur'an and its exegesis, analyzed through thematic and descriptive-analytical interpretative approaches. Two main themes discussed are the limitations of human creativity towards ecology and the relationship between humans and nature. Research findings indicate that the Qur'an explicitly prohibits human behavior that can harm environmental sustainability. Although nature was created to meet human needs, humans are still forbidden to treat the environment carelessly. The Qur'an emphasizes the importance of maintaining ecological balance, forbids isrāf (wastefulness), and warns of punishment in the afterlife for those who damage the environment.
Biosensors and Bioassays for the Medical Detection of Bacillus
Anthracis and Diagnosis of Anthrax
Authors: Pohanka Miroslav
Published: July 2024

Bacillus anthracis is a causative agent of the highly mortal disease anthrax.
This zoonosis is present in nature, but it is also considered one of the most powerful biological
warfare agents. A timely diagnosis is necessary for proper therapy and setting of
epidemiological countermeasures. Current diagnostic methods should be used in specialized
laboratories or medical facilities because there are only a limited number of methods
suitable as hand-held assays or even point-of-care tests for detecting B. anthracis or
anthrax diagnosis. The lateral flow tests are an exception in this regard, but these tests also
have some limitations. Significant progress has been achieved in point-of-care tests
for B. anthracis detection and anthrax diagnosis in various biosensors and bioassays.
This review focuses on current hand-held and point-of-care tests that can easily prove anthrax
or its causative agent outside the context of specialized facilities.
Advancements of Glucose Monitoring Biosensor: Current State, Generations of Technological Progress, and Innovation Dynamics
Authors: Dua Arpita , Debnath Abhijit , Kumar Kunal , Mazumder Rupa , Mazumder Avijit , Singh Rajesh , Mangal Saloni , Sanchitra Jahanvi , Khan Fahad , Tripathi Soumya , Vishwas Sukriti , Chaudhary Hema , Sharma Parul , Srivastava Shikha
Published: July 2024

Glucose monitoring is essential for managing diabetes, and continuous glucose monitoring
biosensors can offer real-time monitoring with little invasiveness. However, challenges
remain in improving sensor accuracy, selectivity, and overall performance. This article aims to
review current trends and recent advancements in glucose-monitoring biosensors while evaluating
their benefits and limitations for diabetes monitoring. An analysis of current literature on
transdermal glucose sensors was conducted, focusing on detection techniques, novel nanomaterials,
and integrated sensor systems. Recent research has led to advancements in electrochemical,
optical, electromagnetic, and sonochemical sensors for transdermal glucose detection. The use of
novel nanomaterials and integrated sensor designs has improved sensitivity, selectivity, and accuracy.
However, issues like calibration requirements, motion artifacts, and skin irritation persist.
Transdermal glucose sensors show promise for non-invasive, convenient diabetes monitoring
but require further enhancements to address limitations in accuracy, reliability, and biocompatibility.
Continued research and innovation focusing on sensor materials, designs, and surface
chemistry is needed to optimize biosensor performance and utility. The study offers a comprehensive
analysis of the present status of technological advancement and highlights areas that
need more research.
LBSA-DRIVER: A Novel Approach to Identifying Cancer Driver Genes
Using List-Based Simulated Annealing
Authors: Atay Yilmaz , Ngobesing Lionel Alangeh , Cingiz Mustafa Ozgur
Published: July 2024

Introduction:

Cancer driver genes are genes responsible for cancer genesis; thus, identifying
cancer-related genes is crucial in fostering cancer treatment. The accuracy in identifying cancer
driver genes within the vast pool of normal passenger genes directly influences the efficacy of
treatment approaches.

Objective:

This research aimed to effectively identify cancer driver genes using the List-based Simulated
Annealing (LBSA) optimization technique.

Method:

The proposed model (LBSA-DRIVER) harnesses a list-based simulated annealing algorithm
within a bipartite network to pinpoint cancer driver genes. The process begins with creating a
bipartite graph that integrates gene mutations and expression data from carefully chosen datasets.
The LBSA algorithm is then applied to the generated graph to identify and rank the genes, drawing
insights from a biological interaction network.

Result:

Following the algorithm's development, rigorous experimental analyses have been conducted
using four benchmark datasets from The Cancer Genome Atlas (TCGA) database. The datasets
used were the Breast Cancer dataset (BRCA), Prostate Adenocarcinoma dataset (PRAD), Ovarian
cancer dataset (OV), and Glioblastoma Multiforme dataset (GBM).

Conclusion:

Our findings, including precision, recall, F-score, and accuracy metrics, provide strong
evidence of the effectiveness of the proposed model in identifying driver genes.
An Overview of Optical Sensing of Copper and its Removal by Different Techniques
Authors: Dutta Srishti , Banjara Dishen Kumar , Pandey Abhilash , Sharma Vansikha , Sahu Devanand , Kumari Niraj , Patra Goutam Kumar
Published: July 2024

:

The identification of heavy metals by sensing technologies is a crucial area of study since these metals are present in the environment and are
hazardous. The in-depth analyses of the probes' structures and sensing capabilities improve our understanding of how to design and develop probes
for the same metal in the future. The third most common metal ion and trace element, copper (Cu2+), is essential to all living things and is involved
in several activities. However, different diseases are caused by excess or deficiency of Cu2+ ions, depending on what the cell requires. For all of
these reasons, optical sensors have concentrated on quick, highly sensitive, and selective real-time detection of Cu2+ ions. Fluorescence in the
refractive index-adsorption from the interactions between light and matter can be measured using optical sensors. Furthermore, due to their strong
advantages which include real-time detection, simplicity and naked eye recognition, low cost, high specificity against analytes, quick reaction, and
the requirement for less complex equipment during analysis they have attracted a lot of attention in recent years. In this review, we covered many
fluoro and chemosensors for the detection of copper, along with their sensing parameters in various mediums and thorough structural analyses.
This review also covers the extraction of copper from the aqueous medium. The use of membrane processes, adsorption, and electrocoagulation is
examined, and the difficulties associated with their application have been presented.
Evaluation of Fluctuations of BRAF Gene Expression and its Polymorphism at rs1267623 in Colorectal Cancer
Authors: Norollahi Seyedeh Elham , Babaei Kosar , Vahidi Sogand , Motaz Seyed Javad Hosseini , Tarbeghan Mahmoud Kalani , Khaleghipour Mostafa , Gharakhyli Elaheh Asghari , Mirhafez Seyed Reza , Samadani Ali Akbar
Published: July 2024

Background:

Molecular markers in Colorectal Cancer (CRC) are needed for more ac-curate classification and personalized treatment. In this way, we investigated the effects of the BRAF gene on clinical outcomes of its expression fluctuations and its polymorphism at rs1267623 in CRC.

Methods:

In this study, 36.36 percent of patients with CRC were women, and 63.63 percent were men. After the pathology department confirmed the tumor of the samples, the stage and grade of the tumor were determined according to the TNM system. Real-time PCR was used to check the expression of the BRAF gene in tumor and non-tumor tissues, and its polymorphism in rs1267623 was also checked using the Tetra-ARMs PCR technique.

Results:

The expression of BRAF in tumor tissues was significantly higher than in non-tumoral tissues (P = 0.001), indicating an upregulation of BRAF gene expression in tumoral tissues. The user's text is empty. Furthermore, there was a significant correlation between BRAF expression and tumor stage (P = 0.001), as well as tumor grade (P = 0.003). However, no significant link was found between lymph node metastasis and distant metastasis of BRAF gene expression (P = 0.3). Additionally, no mutation was detected in the investigation of rs1267623 polymorphism.

Conclusion:

The BRAF gene was upregulated in tumoral tissues. Remarkably, no mutation was found in the rs1267623 polymorphism. As a result, this gene can be used as a biomarker in the diagnosis and treatment of CRC.
Serum MicroRNAs as Predictors of Diagnosis and Drug-resistance in Temporal Lobe Epilepsy: A Preliminary Study
Authors: Bertoli Gloria , Fortunato Francesco , Cava Claudia , Manna Ida , Gallivanone Francesca , Labate Angelo , Panio Antonella , Porro Danilo , Gambardella Antonio
Published: July 2024

Objective:

Temporal lobe epilepsy (TLE) is the most common form of refractory focal
epilepsy, and the current clinical diagnosis is based on EEG, clinical neurological history and neuroimaging findings.

Methods:

So far, there are no blood-based molecular biomarkers of TLE to support clinical diagnosis,
despite the pathogenic mechanisms underlying TLE involving defects in the regulation of gene expression. MicroRNAs (miRNAs) have emerged as important post-transcriptional regulators of gene
expression.

Results:

Recent studies show the feasibility of detecting miRNAs in body fluids; circulating miRNAs
have emerged as potential clinical biomarkers in epilepsy, although the TLE miRNA profile needs to
be addressed. Here, we analysed the diagnostic potential of 8 circulating miRNAs in sera of 52 TLE
patients and 40 age- and sex-matched donor controls by RT-qPCR analyses.

Conclusion:

We found that miR-34a-5p, -106b-5p, -130a-3p, -146a-5p, and -19a-3p are differently
expressed in TLE compared to control subjects, suggesting a diagnostic role. Furthermore, we found
that miR-34a-5p, -106b-5p, -146a-5p and miR-451a could become prognostic biomarkers, being differentially expressed between drug-resistant and drug-responsive TLE subjects. Therefore, serum
miRNAs are diagnostic and drug-resistance predictive molecules of TLE.
Chemical, Functional, and Nutritional Properties of Coriander (Coriandrum Sativum)
Authors: Zambelli Rafael A.
Published: July 2024

Coriander is a plant common to several countries. Its use is associated with
traditional medicine due to its functional and therapeutic properties. However, more
and more coriander has been used in various sectors, such as food, medicine,
pharmaceuticals, and cosmetics. Given the importance of this plant, this chapter aims to
present the main chemical, functional and nutritional characteristics in addition to the
main applications of coriander. The different parts of coriander have several bioactive
components, such as monoterpenes, alkanes, aldehydes, alcohols, pigments, flavonoids,
phenolic compounds, and saturated and unsaturated fatty acids. Because of its
composition, coriander has numerous functional and nutritional properties such as
antioxidant, antimicrobial, antibiofilm, antidiabetic, anxiolytic, and antidepressant
activity, among others. Applications range from studying the impact on
microorganisms to improving animal diets and extract preparations. Therefore, it can
be said that coriander is a plant with multiple applications, and its nutritional potential
should be increasingly explored to promote health benefits. 
Pharmacognostic Profile of a Potent Medicinal Herb: Nardostachys Jatamansi
Authors: Gupta Palak , Naudiyal Neetika , Raypa Pratima , Kumar Vandana A.
Published: July 2024

Nardostachys jatamansi DC, a small, erect, perennial, rhizomatous herb
growing on steep, moist, rocky, undisturbed grassy slopes, is a popular species of
aromatic and medicinal plant. The Sanskrit word “Jata,” which denotes a matted and
uncombed lock of hair, is similar to its rhizome, hence the name “Jatamansi.” The
plant is found between 3000 and 5200 m above sea level in the alpine Himalayas,
which include parts of Uttarakhand, Himachal Pradesh, Arunachal Pradesh, and Sikkim
in India, as well as numerous regions of Nepal, Tibet, China, and Bhutan.

N. jatamansi has been used in ayurveda, ethnomedicine and alternative medicine for a
very long time, going all the way back to the Vedic era (1000–800 B.C.). Its rhizomes
were used as a bitter tonic to cure epilepsy, stimulant, antispasmodic and to treat
hysteria in the traditional Ayurvedic medicinal system. It has a wide range of
therapeutic benefits, including anti-inflammatory, antidepressant-like action,
anticonvulsant, hypotensive, anti-asthmatic, anti-estrogenic, cardioprotective,
neuroprotective, antidiabetic, antifungal, antibacterial, and anticancer characteristics.
Additionally, it functions as a sedative, tranquillizer, hypolipidemic, anti-lipid
peroxidative, antioxidant, and anti-oxidant. In addition, it is used to treat a variety of
neurological conditions, including insomnia, excitation, epilepsy, neurosis, Alzheimer's
disease, and issues with learning and memory. As per various phytochemical studies,
esters, phenolic chemicals, and terpenic ketone are the major components present. Due
to the frequently observed variations in the types of metabolites in the plant,
tremendous medicinal applications can be precisely explored using the database of
antioxidant, antimicrobial, anticancer, antidiabetic and anti-inflammatory activities,
making it a potential candidate for treating oxidative stress and other diseases produced
during pathogenic conditions. For the prevention and treatment of a variety of
pathological illnesses, as well as the side effects associated with them, the use of plants
like N. jatamansi may thereby lessen reliance on synthetic pharmaceuticals.
DESIGN AND ANALYSIS OF THE KOMATSU PC400 EXCAVATOR'S TOOTH BUCKET THICKNESS USING THE FINITE ELEMENT METHOD
Authors: Sutrisna Sutrisna , Prasetiyo Angger Bagus , Juniar Fatur Rizki Anggun
Published: July 2024

Bucket teeth are an important component of an excavator that functions as a material penetrator or digger. This part is prone to failure because it is in direct contact with the ground. This study aims to determine the value of stress, strain, deformation, and safety factors that occur in the Komatsu PC400 excavator bucket teeth against thickness variations of 2.5 mm, 5 mm, 7.5 mm, and 10 mm. This study uses a computer with specifications: processor: Intel (R) Celeron (R) N4000 CPU @ 1.10 GHz, memory: 8 GB. Windows 10 Home Single Language 64-bit Operating System. This computer is equipped with Autodesk Inventor Professional 2023 and ANSYS Workbench R1 2023 software. The method used in this research is a testing method using ANSYS software with a finite element method approach, namely static structural. The simulation results of bucket teeth show the maximum deformation values are 0.16382 mm, 0.13832 mm, 0.1249 mm, and 0.11619 mm, respectively. Furthermore, the maximum equivalent stress values are 108.6 Mpa, 79.712 Mpa, 80.338 Mpa, and 79.992 Mpa, respectively. For the equivalent elastic strain maximum, 0.00052993, 0.00038899, 0.000392, and 0.00039029 were obtained. Then the safety factor value is obtained 3.8214, 5.2062, 5.1657, and 5.188. This shows that the thicker the thickness variation, the better the strength value.
THE EFFECT OF AIRGAP THICKNESS ON THERMAL PROTECTIVE PERFORMANCE IN HEAT RESISTANT CLOTHING
Authors: Fuad Ainul , Wahyudi Slamet , Siswanto Eko
Published: July 2024

The thermal protective performance is provided by thermal protective clothing worn by people who work in high temperature environments and is highly influenced by air gaps. In this paper, effect of air gap thickness on thermal protective performance as indicated by the time before degree burn were investigated. 3 layers of thermal protective clothing with 3 types of fabrics that have been selected will be tested using an experimental method. The research will be conducted through experimental tests using the fabric level method on a bench-scale test apparatus which is equipped with 4 thermocouples and using gas torch as a heat source. The air gap located between the layers of thermal protective clothing will be varied with different thickness in a vertical orientation. The size of the air gap used varies from 01 mm, 2.51 mm, 51 mm, and 7.51 mm. The results show that the temperature distribution in each layer of clothing from the outer shell to the thermal linear has decreased. In addition, time before degree burn which is an indicator on thermal protective performance shows a positive effect on the addition of air gap thickness where the optimum air gap thickness is shown at 7.5 mm variation. It is hoped that the results of this research can be a source or useful information in mechanical engineering, especially in the fields of thermal comfort and fire safety.
Preservasi Spermatozoa Babi Landrace Dalam Tiga Jenis Pengencer Modifikasi
Authors: Papituan Mardan Laes , Nalley Wilmientje Marlene , Hine Thomas Mata
Published: July 2024

Pengenceran semen memiliki dua fungsi utama yaitu untuk memperpanjang masa simpan dan memperbesar volume semen. Penelitian ini bertujuan untuk mengetahui perbandingan penambahan ekstrak daun kelor (EDK) 5% dalam pengencer tris- kuning telur (T-KT), sitrat- kuning telur (S-KT) dan beltsville thawing solutionÂ®-kuning telur (BTSÂ® -KT) terhadap kualitas semen babi landrace selama penyimpanan. Semen babi diambil seminggu sekali menggunakan metode masase dari satu ekor babi jantan berumur 2 tahun dengan kodisi sehat dan organ reproduksi yang normal. Semen yang berkualitas baik dibagi dan diencerkan dengan pengencer perlakuan yaitu : P1: T-KT â€“ 5% EDK , P2: S-KT â€“ 5% EDK dan P3: BTSÂ® -KT â€“ 5% EDK. Kemudian pengenceran semen disimpan dalam syrofoam pada suhu 18-22á¶± C dan dievaluasi setiap 8 jam meliputi motilitas, viabilitas, abnormalitas serta membran plasma utuh (MPU). Rancangan yang digunakan adalah rancangan acak lengkap yang terdiri atas tiga perlakuan dan lima ulangan. Data yang telah diperoleh dianalisis dengan uji anova, apabila terdapat perbedaan yang nyata antar perlakuan maka dilanjutkan dengan uji duncan. Hasil penelitian menunjukkan bahwa pengencer S-KT modifkasi (P2) mempunyai kualitas yang lebih baik (P<0,05) dibandingkan dengan perlakuan lainnya yaitu selama 40 jam dengan motilitas (45,40Â±4,15 %), viabilitas (56,66Â±1,32) dan MPU (55,44Â±5,18%). Kesimpulan dari hasil penelitian ini yaitu pengenceran modifikasi terbaik adalah pengencer S- KT dengan penambahan EDK 5 % (P2).
Intervenção precoce na infância: a perspetiva das famílias
Authors: Oliveira Vânia , Grande Catarina
Published: July 2024

O estudo explora a forma como as famílias do Norte de Portugal percecionam as práticas profissionais das Equipas Locais de Intervenção Precoce (ELI) no âmbito do Sistema Nacional de Intervenção Precoce na Infância (SNIPI), catorze anos após a publicação do Decreto-Lei 281/2009.
Participaram 35 famílias com crianças dos 0 aos 6 anos, acompanhadas pela ELI há pelo menos dois anos. O estudo seguiu uma abordagem qualitativa, envolvendo entrevistas semiestruturadas. Foi utilizada uma análise de conteúdo para categorizar as respostas.
No geral, os resultados indicam que muitas famílias expressaram satisfação com a assistência da ELI, mas observaram áreas que carecem de uma abordagem centrada na família. As famílias também destacaram desafios e sugestões de melhorias. O estudo oferece ideias para melhorar os serviços de Intervenção Precoce na Infância (IPI) no âmbito do SNIPI, incorporando perspetivas familiares diretas.
Interactions between children in preschool: perception of differences in the school inclusion process for children with autism
Authors: Perosa Saigh Jurdi Andrea , Honorio da Silva Alanis Raabe
Published: July 2024

This qualitative research used participant observation in an early childhood education class to understand how children perceive differences among their peers, especially in their relationships with students with autism. A teacher and 28 students aged four to six years participated, two of whom were autistic. Observation was carried out from February to May 2023. The results indicate that the behaviour and relationships that children establish with students with autism vary depending on the level of commitment and interaction that these students present. However, students’ receptivity and acceptance of the differences presented by students with autism were positive, helping them with pedagogical or daily life activities, when necessary. The teacher’s actions brought children closer together and their understanding of their classmates.
Deceptively Simple yet Profoundly Impactful: Text Messaging Interventions to Support Health
Authors: Suffoletto Brian
Published: July 2024

This paper examines the use of text message (SMS) interventions for health-related behavioral support. It first outlines the historical progress in SMS intervention research publications and the variety of funds from US government agencies. A narrative review follows, highlighting the effectiveness of SMS interventions in key health areas, such as physical activity, diet and weight loss, mental health, and substance use, based on published meta-analyses. It then outlines advantages of text messaging compared to other digital modalities, including the real-time capability to collect information and deliver microdoses of intervention support. Crucial design elements are proposed to optimize effectiveness and longitudinal engagement across communication strategies, psychological foundations, and behavior change tactics. We then discuss advanced functionalities, such as the potential for generative artificial intelligence to improve user interaction. Finally, major challenges to implementation are highlighted, including the absence of a dedicated commercial platform, privacy and security concerns with SMS technology, difficulties integrating SMS interventions with medical informatics systems, and concerns about user engagement. Proposed solutions aim to facilitate the broader application and effectiveness of SMS interventions. Our hope is that these insights can assist researchers and practitioners in using SMS interventions to improve health outcomes and reducing disparities.
Ascle—A Python Natural Language Processing Toolkit for Medical Text Generation: Development and Evaluation Study
Authors: Yang Rui , Zeng Qingcheng , You Keen , Qiao Yujie , Huang Lucas , Hsieh Chia-Chun , Rosand Benjamin , Goldwasser Jeremy , Dave Amisha , Keenan Tiarnan , Ke Yuhe , Hong Chuan , Liu Nan , Chew Emily , Radev Dragomir , Lu Zhiyong , Xu Hua , Chen Qingyu , Li Irene
Published: July 2024

Background

Medical texts present significant domain-specific challenges, and manually curating these texts is a time-consuming and labor-intensive process. To address this, natural language processing (NLP) algorithms have been developed to automate text processing. In the biomedical field, various toolkits for text processing exist, which have greatly improved the efficiency of handling unstructured text. However, these existing toolkits tend to emphasize different perspectives, and none of them offer generation capabilities, leaving a significant gap in the current offerings.

Objective

This study aims to describe the development and preliminary evaluation of Ascle. Ascle is tailored for biomedical researchers and clinical staff with an easy-to-use, all-in-one solution that requires minimal programming expertise. For the first time, Ascle provides 4 advanced and challenging generative functions: question-answering, text summarization, text simplification, and machine translation. In addition, Ascle integrates 12 essential NLP functions, along with query and search capabilities for clinical databases.

Methods

We fine-tuned 32 domain-specific language models and evaluated them thoroughly on 27 established benchmarks. In addition, for the question-answering task, we developed a retrieval-augmented generation (RAG) framework for large language models that incorporated a medical knowledge graph with ranking techniques to enhance the reliability of generated answers. Additionally, we conducted a physician validation to assess the quality of generated content beyond automated metrics.

Results

The fine-tuned models and RAG framework consistently enhanced text generation tasks. For example, the fine-tuned models improved the machine translation task by 20.27 in terms of BLEU score. In the question-answering task, the RAG framework raised the ROUGE-L score by 18% over the vanilla models. Physician validation of generated answers showed high scores for readability (4.95/5) and relevancy (4.43/5), with a lower score for accuracy (3.90/5) and completeness (3.31/5).

Conclusions

This study introduces the development and evaluation of Ascle, a user-friendly NLP toolkit designed for medical text generation. All code is publicly available through the Ascle GitHub repository. All fine-tuned language models can be accessed through Hugging Face.
The Use of Telepsychiatry Services in Emergency Settings: Scoping Review (Preprint)
Authors: Shalev Ligat , Eitan Renana , Rose Adam J
Published: July 2024

BACKGROUND

Telepsychiatry (TP), a live video meeting, has been implemented in many contexts and settings. It has a distinct advantage in the psychiatric emergency department (ED) setting, as it expedites expert assessments for psychiatric patients. However, limited knowledge exits for TP’s effectiveness in the ED setting, as well as the process of implementing TP in this setting.

OBJECTIVE

This scoping review aimed to review the existing evidence for the administrative and clinical outcomes for TP in the ED setting and to identify the barriers and facilitators to implementing TP in this setting.

METHODS

The scoping review was conducted according to the guidelines for the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews). Three electronic databases were examined: PubMed, Embase, and Web of Science. The databases were searched from January 2013 to April 2023 for papers and their bibliography. A total of 2816 potentially relevant papers were retrieved from the initial search. Studies were screened and selected independently by 2 authors.

RESULTS

A total of 11 articles were included. Ten papers reported on administrative and clinical outcomes of TP use in the ED setting and 1 on the barriers and facilitators of its implementation. TP is used in urban and rural areas and for settings with and with no on-site psychiatric services. Evidence shows that TP reduced waiting time for psychiatric evaluation, but in some studies, it was associated with prolonged total length of stay in the ED compared with in-person evaluation. Findings indicate lower admission rates in patients assessed with TP in the ED. Limited data were reported for TP costs, its use for involuntary commitment evaluations, and its use for particular subgroups of patients (eg, those with a particular diagnosis). A single paper examined TP implementation process in the ED, which explored the barriers and facilitators for implementation among patients and staff in a rural setting.

CONCLUSIONS

Based on the extant studies, TP seems to be generally feasible and acceptable to key stakeholders. However, this review detected a gap in the literature regarding TP’s effectiveness and implementation process in the ED setting. Specific attention should be paid to the examination of this service for specific groups of patients, as well as its use to enable assessments for possible involuntary commitment.

CLINICALTRIAL
User Experiences and Effects of Expert-led YouTube Mind-Body Interventions on Insomniacs: A Survey Study (Preprint)
Authors: Shin Jung-won , Yoo Jaesung , Kim Hyeyun
Published: July 2024

BACKGROUND

Behavior and psychological therapies for insomnia have been demonstrated to be beneficial in therapy of insomnia. YouTube, a video-based social media platform, has become the most widely-used social media platform and is easily accessible to everyone.

OBJECTIVE

The aim of this study was to investigate the effects of expert-led YouTube-delivered mind-body interventions (MBIs), including mindfulness, breathwork, and mental imagery on sleep disturbances and user satisfaction.

METHODS

In this study, we conducted analysis of data on a survey among 411 users of expert-led YouTube-delivered MBIs, who completed a questionnaire from 20th to 27th November, 2021, retrospectively. The contents of videos had multicomponent approaches, which included education of sleep hygiene, and mind-body interventions.

RESULTS

The participants consisted mostly of females (86.6%) and individuals in their 20s (59.1%). Most of the participants complained of difficulty falling asleep (91%), and 55.2% reported experiencing non-restorative sleep. Post YouTube-delivered MBIs, significant improvements were observed in sleep onset latency, sleep maintenance, sleep quality, daytime dysfunction, and difficulty waking up in the morning (p<0.001). Participants who had improved sleep quality complained of more severe insomnia with psychological stress. 77% of users reported overall convenience and satisfaction with the platform.

CONCLUSIONS

This survey showed the effectiveness of YouTube-delivered MBIs developed by experts. The accessibility advantage of YouTube as a social media platform was effectively utilized, highlighting the need for future research to explore its practical application in clinical settings.

CLINICALTRIAL

None
GME's Short Squeez and Market Regulation
Authors: Zhang Yu
Published: July 2024

GME Century Forbidding War is an event in which American retail investors force to force hedge funds. Based on the analysis of GME Century Forbidding War, this case analyzes the market supervision issues reflected behind this century war, and then explores the roles that enterprises, governments and individuals should play in the current financial market, thus further improving the financial market. Finally, it summarizes the inspiration of GME century's forced air war.
Impacts of Climate Change on Food Security and Sustainable Water Resources in Nigeria
Authors: Agri Eneji Mathias , Bholla Tsenko Joseph , Iyaji Agri Angela , Baba Sunday
Published: July 2024

This study evaluates the impacts of climate change on food security and sustainable water resources in Nigeria. Stratified samples were taken from North Central States of Benue and Plateau, and South-South Cross River State and Akwa-Ibom. These four states are among the thirty six states in Nigeria that have been badly hit by climate change. This study used soft and hardware computer applications including German 12 handheld GPS, and Integrated Land and Water Information System (ILWIS), for data collection. Quantitative and qualitative data were collected for the evaluation. The GIS information software package was used to manipulate and perform feature identification, recognition, classification, calculation, and ground-trotting. A structured questionnaire was also used to collect data on some livelihood activities, the influence of livelihoods activities on water resources, food security, and climate change impacts. Data analysis, found that the forest and water bodies are shrunken. Industrial activities such as oil exploration and exploitation, mining, by Multinational Corporations, illegal mining, grazing, unsustainable farming practices, fishing and hunting for bush meats, bush fire, timber exploitation and deforestation have contributed to climate change. The study recommends climate action and climate diplomacy, building local capacity for resilience, engaging the private sector, partnerships and international assistance.
Unveiling the Scapegoat: An Analysis of the Hero Archetype in Akhil Sharma's 'Family Life’
Authors: Hannah G. , Harinath P. Kusuma
Published: July 2024

This paper employs a literary analysis framework, drawing upon archetypal criticism, psychoanalytic theory, and cultural studies, to explore the portrayal of the scapegoat hero archetype in Akhil Sharma's novel ‘Family Life’. The qualitative research approach of this work, examines the protagonist's interactions within the family dynamics, themes of guilt and redemption, and the influence of cultural and societal factors. Further the research also explores the parallels between traditional scapegoat figures in literature and the portrayal of scapegoat hero of contemporary individuals in Akhil Sharma’s ‘Family Life’. This paper illuminates Sharma's nuanced portrayal of guilt, sacrifice, and the quest for identity within the immigrant family. Furthermore, by contextualizing the novel within the present era, this study underscores the enduring relevance of Sharma's exploration of these themes. And ultimately contributes to our understanding by offering insights into the complexities of portrayal of the scapegoat hero archetype influenced by immigrant experiences and the dynamics of family life.
Fathi, ’24 Formulaic Politeness in Moroccan Arabic
Authors: Fathi S.
Published: July 2024

This paper aims to show that Moroccan males and females do make use of polite speech behavior that cannot be accounted for in Brown & Levinson’s framework of politeness. In other words, such highly expressive speech behavior is different from Brown & Levinson’s politeness strategies in many respects. While such politeness behavior attends to the face wants of the hearer, it cannot be considered as politeness strategies in Brown & Levinson’s sense, but rather as Politeness Formulas. Politeness formulas differ also from strategies with respect to their politeness conversational structure.
Sustainability Indicators Correlation Matrix
Authors: Bechir Mahamat Habib , Martinez D. Ferreria- , Aguera A. Lopez-
Published: July 2024

Abstract: This study explores the complex interplay between economic growth, environmental preservation, and energy efficiency in the context of sustainable development. Leveraging analytical tools such as the OSeMOSYS model and Pearson correlation coefficient, the research investigates how economic decisions impact energy resource utilization and environmental quality. Key sustainability indicators, including Energy Payback Time (EPBT), Internal Rate of Return (ITR), and Climate Change Impact Mitigation (IMPcc), are analyzed within the framework of the Atlantis energy system. The study emphasizes the need to balance economic priorities with environmental considerations to achieve sustainability objectives effectively. Furthermore, the research evaluates the correlation between sustainability indicators when integrated into the optimization process of the OSeMOSYS energy modeling system. This approach, advocated in previous studies, underscores the importance of incorporating sustainability metrics into decision-making processes. In conclusion, the findings highlight the necessity of reevaluating the weighting of indicators within optimization functions to prioritize sustainability goals. By providing insights into the complex relationships between economic, energy, and environmental factors, the study contributes to advancing sustainable development practices for policymakers, businesses, and society as a whole.
Comparative Study of Microcontoller: ARDUINO UNO, RASPBERRY PI 4, ESP 32
Authors: Goyal Yash
Published: July 2024

Abstract: This paper provides a comparative study of three popular microcontrollers: Arduino Uno, Raspberry Pi 4, and ESP32. Arduino Uno is known for its simplicity and low power consumption, making it ideal for educational and small-scale projects. Raspberry Pi 4 offers high computational power and extensive connectivity, suitable for IoT gateways, media centers, and industrial automation. ESP32 combines robust wireless connectivity with efficient processing, perfect for IoT applications, smart home devices, and wearable electronics. The study evaluates their technical specifications, performance, development environments, and use cases, helping developers choose the best microcontroller for their projects
A Review on Synthesis of Azoles
Authors: Raut Shivani V.
Published: July 2024

Abstract: Heterocyclic compounds form a major class of compounds in chemistry. There has been considerable interest in the development of novel heterocyclic compounds with varied biological activities. Azoles are famous and widespread scaffold in the pharmaceutical industry due to their range of activities. Diazocarbonyl compounds have found numerous applications in many areas of chemistry. Among the most developed fields of diazo compounds. This approach represents a useful alternative to more conventional methods of the synthesis of azoles. The present review discussed the different characteristics of the azoles of interest, to recognize the differences in pharmacolog, safety, toxicity and potential drug interactions of these antifungal agents.
Students' clarification stages in analyzing mathematical problems in the implementation of the OBE curriculum
Authors: Effendi Moh. Mahfud , Rosyadi Alfiani Athma Putri
Published: July 2024

Solving mathematical problems is an important aspect of the learning process, but in reality, many students experience difficulty in solving them. The aim of this research is to explain the stages of student qualifications in analyzing mathematical problems, especially in implementing the OBE curriculum. This qualitative descriptive research uses an interactive model, with a sample size of 40 students taking the Euclidean Geometry course. Data collection uses questionnaires, tests and interviews which have been declared valid with a score of 90% and reliable with a score of 87%. Data collection stages include; (1) differentiating, (2) organizing, and (3) connecting aspects. Students' clarification stages in the analytical process of solving mathematical problems consist of differentiating, organizing and connecting. Analysis of research data uses descriptive, namely percentages. Based on the results of the analysis, it is known that the level of clarity of students in analyzing mathematical problems is 66.67%, and only 20% of students have a level of conformity of 100%. The organizing stage had the lowest score (60%) compared to the differentiating (66.67%) and connecting (73.33%) stages. The advice that can be given is that at the deconstruction stage, it can be studied if there are differences of opinion, while in the exploration process, it can be explained using HOTS.
Science journalism in the Kingdom of Saudi Arabia: news sources engagement and [lack of] science accountability
Authors: Alhuntushi Abdullah , Lugo-Ocando Jairo
Published: July 2024

In this article we explore normative professional expectations around science journalists in Saudi Arabia (KSA) and how news reporters do access, engage with, and use news sources. Against broader and more universal normative expectations, we found that journalists in that country used a low diversity of sources in science news reporting and depended on official and public relations sources. These findings point to a current lack of criticality in science media reporting in KSA and limited ability for media to hold science to account. In so doing, we offer explanations for the divergence and gaps.
Additional education for children:The state and trends in the regional dimension
Authors: Speka K.I. ,   The Russian Presidential Academy of National Economy  and  Public  Administration,  the  Far-Eastern  institute of management – branch of RANEPA
Published: July 2024

The article examines modern mechanisms for ensuring the accessibility of additional education for children in the context of the implementation of the state policy priority area. The analysis of theoretical approaches to the problem is illustrated by the data of the federal statistical observation of recent years and the results of the All-Russian survey on the development of additional education for schoolchildren and their parents. The presented data reflect not only the state of development of additional education, but also the dynamics of the processes in this area, which allows the author to draw scientifically sound conclusions on the development of the system of additional education for children.
State Support of Transport Development at the Present Stage: Impact on the Transport Complex of the Far East
Authors: Bardal A.B. ,   The Economic Research Institute FEB RAS
Published: July 2024

The article studies the methods of state stimulation of transport development at the present stage. Under the conditions of the «Turn to the East» and geopolitical changes occurring since 2022, Russia's foreign trade flows are being reoriented from European to southern and eastern directions. This has increased the workload of the Far East transportation complex, which provides Russia's access to the markets of Asia-Pacific Region countries (primarily PRC). The increasing scale of cargo flows revealed imbalances in the operation of transportation and aggravated the issue of infrastructure development. The state has developed a system of measures to stimulate the development of transportation. The article suggests their grouping based on the object of influence, market segment and form of regulation. It has shown that the state uses various mechanisms to stimulate private investment in infrastructure development: public-private partnership (PPP), infrastructure bonds, budget loans, etc. The article presents the application of public-private partnerships (PPP) in the Far Eastern Federal District (FEFD) in the field of transport: 16 projects are being implemented, the total investment capacity of which amounts to 223.0 billion rubles. The analysis of the project structure allowed to identify their peculiarities. PPPs are used to implement projects significant for the integrated development of transport in the macro-region, characterized by a significant investment capacity and a long payback period. Examples of such projects are the construction of the cross-border road bridge Blagoveshchensk (RF) - Heihe (PRC), modernization of the international airport «Khabarovsk» (New) named after G. I. Nevelskoy. In general, when implementing PPP projects in the field of transportation, the key role remains with the state, which degree of participation is increasing due to a number of factors: 1) increase in the number of projects in which public sector companies (established by government agencies or development corporations) act as concessionaire; 2) expansion of support mechanisms applied.
Economic growth of an open regional system: the Russian Far East and Khabarovsk Territory
Authors: Izotov D.A. ,   The Economic Research Institute of FEB RAS
Published: July 2024

The purpose of the study is to assess the factors of growth of the Russian Far East (RFE) and the Khabarovsk Territory in 2000-2021. The article shows that in the long term, the rates of economic growth of the RFE and the Khabarovsk Territory lagged behind as a whole, despite the high rates of capital growth and the significant openness of their economies. The assessment of the production function indicated that in order to maintain growth rates, the RFE’s economy required high rates of capital growth, and the negative growth rates of labor were compensated by other factors. It was determined that capital and neutral technological progress formed the overall positive dynamics of the RFE economy, and trade was its important addition. It was found that the share of trade with foreign countries in the RFE’s economic growth was almost twice as large as trade with the domestic market. Unlike the RFE, to maintain economic growth in the Khabarovsk Territory a smaller increase in capital and labor was needed. At the same time, the economic growth of the Khabarovsk Territory was generated mainly by capital and trade. It was found that the share of trade with foreign countries in the economic growth of the Khabarovsk Territory exceeded the share of trade with the domestic market. It was determined that a large-scale export with low added value had a relatively small impact on the economic growth of the RFE and the Khabarovsk Territory, while import had a noticeable impact on it. It is assumed that with the shift of the country’s economic activity to the East, the role of South regions of the RFE (including the Khabarovsk Territory) as an “intermediary” between domestic and foreign markets may allow them to use their existing advantages to accelerate their economic growth.
Projects and Realities of Forming a Great Eurasian Space
Authors: Akaev A. A. , Kefeli I. F.
Published: July 2024

Aim. Analyze three options for the development and construction of the Eurasian space (Russian, Chinese and Turkic) and identify the advantages and risks associated with both the expansion of integration processes and external influence on states that are members of coalitions of the nonWestern world.Tasks. To trace the evolution of supranational structural formations in the Eurasian space after the collapse of the Soviet Union and their appearance in declarations, agreements and other legal documents, starting with statements about “the formation and development of a common economic space, pan-European and Eurasian markets”.To identify the characteristic features of globalization of all spheres of human existence, which has given rise to the need to understand the “landscape of global risks”, “global existential catastrophe” as an event leading “to the end of the existence of our descendants”, which together determined the transition to the formation of nation states, geopolitical and geo-economic coalitions in the Greater Eurasia space (“Central Asian Five”, EEAS, SCO, CSTO, UTC).Results. The concept of three main projects for the construction of Greater Eurasia is substantiated: Russian, based on the revival of the Eurasian ideology of N. S. Trubetskoy, P. N. Savitsky and G. V. Vernadsky; the Chinese “Belt and Road”, aimed at transforming the idea of the Great Silk Road into a Community of a Common Destiny for Humanity; Turkic, claiming to recreate the Turkic civilization with the goal of “bringing world civilizations closer together” on the Eurasian continent.The author’s position is argued regarding the need to ensure coplanarity and unidirectionality of the three vectors of implementation of Eurasian projects with the consistency of political decisions and actions of the three poles of power in the Greater Eurasian space — Russia, China and Turkey.Conclusions. Currently, the coordination of political decisions and actions of the three poles of power in the Greater Eurasian space, taking into account the principles of convergence of national interests in interstate unions, global geopolitical processes of multi-agent interaction and global security strategy in a polycentric world, is becoming relevant.