bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGEMBANGAN LKPD BERBASIS MODEL PEMBELAJARAN INDEX CARD MATCH UNTUK MENINGKATKAN KETERAMPILAN MEMBACA PERMULAAN PADA PELAJARAN BAHASA INDONESIA DI KELAS I SD NEGERI 104202 BANDAR SETIA
Authors: Cahyani Regita , Irsan Irsan , Lubis Wildansyah , Simbolon Naeklan , Faisal Faisal
Published: July 2024

Penelitian dilaksanakan dengan tujuan untuk mengembangkan Lembar Kerja Peserta Didik (LKPD) sehingga menghasilkan produk LKPD berbasis model pembelajaran index card match Bahasa Indonesia kelas I, mendeskripsikan kelayakan LKPD berbasis model pembelajaran index card match Bahasa Indonesia kelas I. Penelitian ini menggunakan metode Research and Development (R&D) dengan menggunakan model ADDIE. Dalam penelitian model ADDIE ada 4 tahapan penelitian yang dilakukan yakni Analysis, Design, Development, Implementation, dan Evaluation. Adapun hasil penelitian ini ialah telah dihasilkan produk Lembar Kerja Peserta Didik (LKPD) berbasis model pembelajaran index card match Bahasa Indonesia kelas I dengan rata-rata skor kelayakan 91,66% dari ahli materi dan termasuk kategori sangat layak, 86,15% dari ahli desain dan termasuk kategori sangat layak, 92% dari praktisi pendidikan dan termasuk kategori sangat layak. Sehingga dapat disimpulkan bahwa produk Lembar Kerja Peserta Didik (LKPD) berbasis model pembelajaran index card match Bahasa Indonesia kelas I layak digunakan sebagai bahan ajar tambahan di sekolah terkhusus kelas I.
PENGEMBANGAN BAHAN AJAR IPAS BERBASIS GOOGLE SLIDE MATERI MAGNET, LISTRIK, DAN TEKNOLOGI UNTUK KEHIDUPAN, KELAS V SD MUHAMMADIYAH 21 MEDAN
Authors: Fitriani Dini , Rozi Fahrur , Nurmayani Dr. , Prawijaya Septian , Tambunan Husna Parluhutan
Published: July 2024

This research aims to determine the feasibility, practicality and effectiveness of science and science teaching material products based on Google Slides, Magnet, Electricity and Technology Materials for Life for Class V at SD Muhammadiyah 21 Medan. The method used in this research is the 4D Model Research and Development (R&D) method, namely Define, Design, Development and Dissemination. The research subjects were students in class V-A of SD Muhammadiyah 21 Medan. The results of this research are Google Slide-based science teaching materials which include 3 aspects, namely: assessment of the appropriateness aspect of the material content with a percentage result of 77% (Valid/Suitable for use). Feasibility aspect of design and technology appearance with a percentage of 81% (Valid/Appropriate to use). The practicality aspect obtained a percentage result of 93.3% (Valid/Appropriate for use). Meanwhile, the effectiveness results from the pre-test and post-test were 80.28%. Based on the results of the feasibility test, practicality and effectiveness of this product, it can be concluded that this Google Slides Based Science Teaching Material is very feasible, practical and effective to use.Keywords: Science and Technology Teaching Materials, Google Slides Based, Elementary School Students
Impact of Peer Feedback on the Quality of Academic Sessions in an Emergency Medicine Training Program: A Quality Improvement Project.
Authors: Rahman Emranur , Karimi Sareh , Husain Mansoor
Published: July 2024

Introduction
Feedback is at the heart of medical education; different teaching encounters call for different types of feedback.
(1). Feedback serves as a powerful tool in the realm of education, playing a vital role in shaping students\' learning experiences and fostering their academic growth. Recognizing the importance of feedback and implementing effective feedback mechanisms can lead to enhanced learning outcomes, improved performance and increased motivation among learners(3). It can be incorporated to enhance teaching and learning techniques since it has an immediate impact on the process of acquiring knowledge and has a direct impact on both teaching and learning(4).
Methods:
We designed a project to improve the quality of our academic day by integrating feedback forms into all our academic activities. In November 2022 we sent out a survey to all residents to evaluate the quality of the sessions in the academic day. Based on the responses received we incorporated feedback forms into each session to allow the audience to evaluate the speakers. All presenters presenting between February to July 2023 were provided with a QR code to be presented at the end of their presentation, to allow instant feedback by peers. At the end of the 6 month cycle we sent out 2 sets of surveys to both the speakers and audience to assess the impact of peer feedback on the quality of sessions presented during academic day. The surveys asked the audience and speakers to rate their experience of feedback forms and how it has impacted their performance. Each question was scored on a likert scale 1 to 5 with 1 being strongly disagree to 5 being strongly agree.
Results:
30 out of 33 current residents responded to the surveys. Based on the responses received, there has been a positive outcome on all domains for both audience and speakers (Fig 1,2).
Conclusion:
In the era of formative assessment peer feedback will go a long way in improving the quality of educational activities. Our project has similar outcomes to multiple similar studies done elsewhere which have demonstrated an improvement in their educational experience (2). We hope our findings can aspire other programs in the region to incorporate similar feedback forms into their sessions.
Zeytinyağı Sanayii Yan Ürünü Karasuyun Macar Fiğ- tritikale Silajlarının Kalitesi ve Mikrobiyolojik Özelliklerine Etkisi
Authors: Arslan Duru Asuman , Aksu Elmalı Dilek , Yüksel Osman , Duru Metin
Published: July 2024

Bu çalışmada amaç, zeytinyağı sanayii yan ürünü olan karasuyun Macar fiğ-tritikale silajlarına farklı dozlarda ilavesinin kimyasal kompozisyon, fermentasyon, fiziksel, mikrobiyolojik özellikleri ve in vitro sindirilebilirlikleri üzerine etkisini incelemektir. Araştırma silajları belirtilen şekilde oluşturulmuştur: (i) %100 Macar fiğ-tritikale silajı (kontrol); (ii) %95 Macar fiğ-tritikale + %5 karasu; (iii) %90 Macar fiğ-tritikale + %10 karasu; (iv) %85 Macar fiğ-tritikale + %15 karasu; (v) %80 Macar fiğ-tritikale + %20 karasu. Silolama dönemi 56 gün devam etmiştir. Sonuç olarak, karasu ilavesiyle silajların koku, organik madde, pH ve suda çözünebilir karbonhidrat içerikleri azalmış; kuru madde, ham kül, ADF, ham yağ ve Fleig puanı artmıştır. Ham protein, ham selüloz, NDF, amonyak azot, laktik asit bakterileri, in vitro kuru madde ve organik madde sindirilebilirlikleri bakımından görülen farklılıklar önemli bulunmamıştır. Araştırma silajlarında sülfit indirgeyen anaeroblar, Listeria spp., Enterobactericeae ve maya içeriğine rastlanmamıştır. Küf içeriği, %15 karasu içeren grupta bir örnekte saptanmıştır. Araştırma sonunda, Macar fiğ-tritikale karışımlarından oluşan silajlara %20 düzeyine kadar karasu ilavesinin herhangi bir olumsuz etkisinin olmadığı sonucuna varılmıştır.
AutoCAD Yazılımı Kullanılarak Alansal ve Zamansal Bazlı İklim Sınıfı ve Referans Evapotranspirasyon Haritalarının Oluşturulması – Doğu Anadolu Bölgesi, Türkiye Örneği
Authors: Usta Selçuk
Published: July 2024

Bu çalışmada, Türkiye’nin Doğu Anadolu Bölgesi için alansal ve zamansal bazlı iklim sınıfı ve ETo haritalarının oluşturulması amaçlanmıştır. Öncelikle, bölgedeki 15 şehrin De Martonne kuraklık indeksi yöntemine göre ay bazında iklim sınıfları belirlenmiştir. Daha sonra bölgedeki mevcut meteoroloji istasyonları tarafından ölçülen iklim verilerinin uzun yıllar ortalama değerleri kullanılarak, FAO-56 Penman-Monteith yöntemi tabanlı CROPWAT yazılımı ile şehir bazında aylık ortalama ETo değerleri hesaplanmıştır. Elde edilen iklim sınıfı ve ETo değerlerinin alansal ve zamansal değişimini gösteren haritaların oluşturulmasında ise AutoCAD yazılımı kullanılmıştır. Bu haritalardan okunan ETo değerleri, T.C. Tarımsal Araştırmalar ve Politikalar Genel Müdürlüğü (TAGEM) tarafından hazırlanan “Türkiye’de Sulanan Bitkilerin Bitki Su Tüketimleri” isimli rehberde bölge şehirleri için verilen ETo değerleri ile karşılaştırılmıştır. Karşılaştırma kriteri olarak ortalama mutlak göreceli hata oranı (MAPE) dikkate alınmıştır. ETo haritaları kullanılarak doğruluk oranı %89,85 (MAPE= %10,15) düzeyine ulaşan günlük ortalama ETo değerleri tahmin edilmiştir. İklim sınıfı ve ETo değerlerinin konum ve zamana bağlı olarak kolaylıkla belirlenebildiği bu haritaların özellikle ETo hesaplamaları için gerekli olan güncel iklim verilerinin ölçülemediği veya temin edilemediği kırsal kesimlerdeki ETo’a dayalı bitki su tüketimi (ETc) ve sulama programı çalışmaları ile sulama sistemleri ve su iletim yapılarının tasarımı ve projelendirilmesinde kullanılabileceği sonucuna ulaşılmıştır.
Digital Transformation of Public Services: An Analysis of the Effectiveness of Online Services at the Local Government Level
Authors: Indar Indra Nur , Razi Dien Fakhrur , Atmansyah Lutfi , Yani Andi Ahmad , Ismail Nuralamsyah
Published: July 2024

This study examines the effectiveness of online services at the local level (District) Office which sees the existence of E-Gov encouraging the government to create good governance in providing information needs and transparency to the community. The renewal of public services in the reform era is the main focus of the government as an effort to realize good governance. The research method used is qualitative. This research uses the concept proposed by Pedrosa et al (2022) which uses eight indicators of the effectiveness of digital public services: ease of use, usefulness, simplicity, reliability, availability, understandable, consistent, and fast. The results showed that online-based services at the agency were effective in several aspects, such as trust and availability, but there were still shortcomings in the aspects of simplicity and consistency. Online services are considered easy to find through familiar channels and have a fast response, less than an hour. Nevertheless, the implementation of online service SOPs still needs to be improved. This study concludes that online services have become an attractive asset in the effort to transform the digitalization of public services.
Right to Sue (Citizen Law Suit) Air Pollution as an Alternative Dispute Settlement
Authors: Ulfanora Ulfanora
Published: July 2024

A good and healthy environment is a human right of every Indonesian citizen. The mandate of the 1945 Constitution is not obtained by citizens as they should. The proof is that high air pollution, such as air quality in some areas, causes environmental damage. As for the negative impact of air pollution, in addition to material losses, it also causes immaterial losses in poor air quality. Facing the occurrence of environmental damage due to air pollution in the city of Jakarta, citizens have the right to sue the government as state administrators who have neglected to protect the rights of their citizens, as regulated in Article 91 paragraph (1) and (2) of Law no. 32 of 2009. The results of this study are that the Citizen Lawsuit lawsuit becomes a forum for the community if they experience losses due to pollution and environmental damage. This Citizen Lawsuit lawsuit only asks for accountability for Government policies that result in losses for citizens, such as the lawsuit filed by the Optimistic Capital Coalition on Number 374/Pdt.G/2019/Pn.Jkt.Pst which was received by the Panel of Judges in 2021.
Perlindungan Hukum terhadap Pekerja Alih Daya dalam Perjanjian Kerja dalam Hal Terjadi Peralihan Perusahaan Penyedia Jasa
Authors: Fitri Idul , Khairani Khairani , Yasniwati Yasniwati
Published: July 2024

Outsourced labor is a part of employment growth in various economic sectors. As part of the workforce, outsourcing workers must also receive protection for their rights as outsourcing workers. One of the things that needs to be protected is in the event of a transfer of service provider company. Therefore, it is necessary to study the protection of the rights of outsourced workers. In this case, the research was conducted at the M. Zein Painan Hospital. Outsourced workers at M. Zein Painan Hospital must be protected by Indonesian law. The study used empirical research methods by collecting data from related parties, namely outsourcing workers, service provider companies, and service users, in this case, Dr. M Zein Painan. One form of legal protection and certainty, especially for workers, is through the implementation of work agreements. Analysis and discussion of the results obtained are: (a) Forms of legal protection for outsourced workers in work agreements at RSUDi Dr. M. Zein Painan, namely protection of wages, protection of working time, and protection of rest time as well as protection against termination of employment (b) Implementation of work agreements for outsourced workers when there is a change in service provider company can be implemented well with the existence of an agreement Work.
Tinjauan Historis Implikasi Nasionalisasi Perusahaan Perkebunan Karet di Sumatera Utara Tahun 1958-1960
Authors: Royani Reni , Triaristina Aprilia , Sinaga Risma Margaretha
Published: July 2024

Nasionalisasi perusahaan Belanda di Indonesia memiliki Implikasi terhadap Perusahaan perkebunan karet di wilayah Sumatera Utara pada tahun 1958-1960. Penelitian ini dilakukan  dengan tujuan untuk mengetahui implikasi nasionalisasi perusahaan perkebunan karet di Sumatera Utara Tahun 1958-1960. Metode penelitian yang digunakan dalam penelitian ini adalah metode penelitian historis dengan empat langkah penelitian yaitu heuristic, kritik, interpretasi dan historiografi. Teknik pengumpulan data yang digunakan adalah dokumentasi dan kepustakaan. Kemudian analisis data dilakukan menggunakan cara analisis data historis. Hasil penelitian ini menunjukan bahwa nasionalisasi perusahaan perkebunan karet membawa perubahan baik dari sisi internal maupun eksternal nya. Dari segi internalnya terjadi perubahan pada manajemen perusahaan, kebijakan perusahaan dan hasil produksi. Pada sisi eksternalnya terjadi perubahan pada penanaman modal perusahaan perkebunan karet. Perubahan-perubahan yang terjadi pasca nasionalisasi ini memberikan dampak sosial dan ekonomi bagi perusahaan tersebut untuk kedepannya.
The Ifood B side campaign and complexity in digital work relations: unveiling other revascularizations?
Authors: Cavalcante Jackelin Wertheimer , Carreon Renata de Oliveira
Published: July 2024

This article aims to reflect on discourses that permeate the relations between workers of the new service proletariat in the digital age. Based on the perspectives of Digital Discourse Analysis and Popular Linguistics, we will address some important aspects about the advent and expansion of a new digital service proletariat, deprived of several rights, including that of organization and whose work gains momentum with new digital business models, capable of connecting different types of work with their different degrees of precariousness. The theoretical-methodological foundation articulates Digital Discourse Analysis as conceived by Marie-Anne Paveau (2019, 2021) and Cristiane Dias (2018, 2019) and Popular Linguistics, which, according to Preston (2021), focuses on what is what happens in language and what non-linguists say about it. The object of analysis is the material collected by the report made by apublica.org (04.04.2022), which constitutes the corpus related to this digital proletariat. In this case, language is related to an ideological construction that propels meta-discourses that reveal power relations. These, ultimately, go back to relations between subordinate workers. Finally, as they are inscribed in a situation of discursive obstructions of different natures, the discourses inferred from the report allow accessing voices and glimpse processes of discursive revascularization (BARONAS; LOURENÇO, 2022) simple, complex and even of other natures.
Linguistique populaire, socioterminologie, autorité: le cas des forums des enérgies renouvables
Authors: Vicari Stefano
Published: July 2024

Dans cette contribution je me propose de montrer l’intérêt d’intégrer la perspective de la folk linguistics (Niedzielski; Preston, 2000) ou linguistique populaire (Achard-Bayle;  Paveau, 2008) dans le cadre des études socioterminologiques (Gaudin, 1999) à partir notamment des notions de confiance et d’autorité. Pour ce faire j’ai choisi un domaine sur lequel j’ai travaillé quelques années après ma thèse de doctorat, c’est-à-dire la terminologie des énergies renouvelables telle qu’elle circule dans des forums Internet.
Analysis of Learning Situation and Training Suggestions for Non-traditional Students in Vocational Colleges
Authors: Li Qiong
Published: July 2024

With the popularization of higher education in China, the proportion of non-traditional students in higher education will continue to increase. Vocational colleges will be the main institutions in China that accept non-traditional students to attend universities. This student group is still very different from the traditional student group. The analysis of the learning situation of non-traditional student groups is a prerequisite and foundation for vocational colleges to explore the high-quality cultivation of this group. Through investigation and analysis of non-traditional students in vocational colleges, summarizing their learning characteristics strengths, and weaknesses, this article provides corresponding suggestions for high-quality cultivation of this student group in vocational colleges.
Research on the Reformation and Innovation of College Student Council Work in the New Media Environment
Authors: Chen Zichu
Published: July 2024

Promoting the work of the college student council aims to strengthen the ideological and political education of college students and guide them to establish correct values. Universities should exert great importance on the transformation of work content and methods in the new media environment, continuously innovate work concepts, and adopt work models that are suitable for the development needs and laws of contemporary college students to guide them to learn advanced ideas and face various challenges from life, learning, and even future work. Based on this, this article first analyzes the impact of new media on the work of college student councils, and the innovative ideas it brings. Then, it summarizes relevant work experience and proposes feasible reformation and innovation paths for college council work.
Research on Higher Education Model Innovation Based on Big Data Technology
Authors: Wang Zhanfeng , Wang Lili
Published: July 2024

With the deepening of the reform of higher education, the work of higher education should be further optimized. Teachers should actively introduce new education concepts and teaching methods, so as to better arouse students’ interest in learning, strengthen their understanding and application of the knowledge, and improve the education effect. Big data technology, as a popular educational auxiliary means, can greatly enrich the content of higher education classroom teaching, broaden the path of education, and greatly promote the more comprehensive development of students. In view of this, this article will analyze the higher education model based on big data technology and put forward some strategies for your colleges’ reference.
The Practice of Italian Pronunciation Teaching in Vocal Music Teaching in Colleges and Universities
Authors: Li Lutailong
Published: July 2024

With the development of the world, vocal music teaching in colleges and universities has been further optimized. Teachers in this new era actively introduce new education concepts and teaching methods, to better arouse students’ interest, strengthen their understanding and application of what they have learned, and improve the education effect. As a popular teaching aid at present, Italian vocal music teaching can greatly enrich the content of vocal music teaching in colleges and universities, broaden the path of education, and greatly promote the comprehensive development of students. In this aspect, this paper will analyze the practice of Italian pronunciation teaching in college vocal music teaching and put forward some opinions for your colleagues’ reference.
Optimization Path for Employment-oriented Training of Computer Majors in Higher Vocational Education
Authors: Wang Yanru , Zhang Feng
Published: July 2024

This article proposes an optimization path for the employment-oriented demand in the training of computer professionals in vocational colleges. A series of improvement measures have been proposed by analyzing the current situation. Firstly, focus on optimizing the practical teaching process and increasing internship opportunities for cooperation with enterprises, to enhance students’ practical skills and work experience. Secondly, strengthen the cultivation of soft skills, including communication and teamwork abilities, and cultivate students’ ability to adapt to the real working environment. At the same time, establish a close integration model between industry and education, offer courses closely related to the needs of enterprises, and improve the employment competitiveness of graduates. Finally, teachers should encourage students to participate in project practice, cultivate the ability to solve practical problems, pay attention to industry development trends, and flexibly adjust teaching content. Through these measures, it is expected to better meet the demand for high-quality talents in the computer industry, and enhance the employment competitiveness and career adaptability of graduates.
Guided by the Teacher Teaching Ability Competition, Promoting the Digital Reform of Teaching
Authors: Geng Huamei , Cui Fuhong , Han Yani , Wei Xian
Published: July 2024

In the current context of industrial digital transformation and upgrading, the digital transformation and upgrading of vocational education is imperative. This article analyzes the current situation of digital teaching in vocational colleges, combined with the analysis of the teaching ability competition plan of the National Vocational Skills Competition for Teachers, and explores and analyzes the specific measures for the reform of digital teaching in vocational colleges during the digital transformation process: (1) Improving and optimizing digital infrastructure, creating a new environment for digital teaching, (2) Using teaching ability competitions as a driving force to promote digital classroom reform, (3) Putting effort into the technological application to improve the digital literacy and execution ability of teachers.
Application Research of Virtual Simulation System From Complexity Perspective
Authors: Jiang Hui
Published: July 2024

The “Intelligent Manufacturing Technology and its Application” in higher vocational colleges has some problems such as limited practical training resources, high maintenance costs and security risks in the running process. Even if there is a simulation, it is a simple simulation. The repetitive imitation of traditional practical training links, and the virtual simulation teaching does not fully reflect the characteristics of virtuality, interactivity and spatiotemporality. Because of the existing problems in the training simulation development and application of the current curriculum, the development and application of the virtual simulation system under the complexity perspective is proposed. The results show that this application can improve the effectiveness of virtual system applications.
Agile Software Development: The Experience of Working in Sprints [Research in Progress]
Authors: Nakash Maayan
Published: July 2024

Aim/Purpose.
This exploratory study seeks to surface a richer understanding regarding the direct experience of software developers (SDs) working in sprints as part of the adoption of agile methodology principles.

Background.
The software development industry is increasingly adopting agile development methods. In the agile methodology, the delivery cycle is broken down into sprints, also known as iterations. There is relatively little empirical knowledge produced to date on agile software development methods. Specifically, the SDs’ authentic work experience in agile sprints is a subject that is missing from the literature.

Methodology.
This paper presents results based on data collected through preliminary in-depth interviews with SDs working in research and development teams of Israeli high-tech companies. As a heuristic device for describing their experience, an interpretive phenomenological perspective was adopted. Content analysis was used as a central methodology to analyze the data.

Findings.
The preliminary results present the ways of managing a development project in sprints, put a spotlight on the value of the agile method, and provide a unique glimpse of its challenges.

Contribution.
Our work adds to the growing body of research investigating the SDs’ perceptions. The preliminary results develop the theoretical and practical knowledge related to managing agile sprints, with reference to optimal communication, monitoring, control, and knowledge sharing among SDs in agile projects.
How Different Are Johnson and Wang? Documenting Discrepancies in the Records of Ethnic Scholars in Scopus
Authors: Pham Trang
Published: July 2024

Aim/Purpose.
This study captures and describes the discrepancies in the performance matrices of comparable Chinese and American scholars as recorded by Scopus.

Background.
The contributions of Chinese scholars to the global knowledge enterprise are increasing, whereas indexing bibliometric databases (e.g., Scopus) are not optimally designed to track their names and record their work precisely.

Methodology.
Coarsened exact matching was employed to construct two samples of comparable Chinese and American scholars in terms of gender, fields of work, educational backgrounds, experience, and workplace. Under 200 scholars, around a third being Chinese and the rest American scholars, were selected through this data construction method. Statistical tests, including logit regressions, Poisson regression, and fractional response models, were applied to both samples to measure and verify the discrepancies stored within their Scopus accounts.

Contribution.
This study complicates the theory of academic identity development, especially on the intellectual strand, as it shows ethnic scholars may face more errors in how their track records are stored and presented. This study also provides inputs for the discussion of algorithmic discrimination from the academic context and to the scientific community.

Findings.
This paper finds that Chinese scholars are more prone to imprecise records in Scopus (i.e., more duplicate accounts, a higher gap between the best statistic accounts, and the total numbers of publications and citations) than their American counterparts. These findings are consistent across two samples and with different statistical tests.

Recommendations for Practitioners.
This paper suggests practitioners and administrators at research institutions treat scholars’ metrics presented in Scopus or other bibliometric databases with caution while evaluating ethnic scholars’ contributions.

Recommendations for Researchers.
Scholars and researchers are suggested to dedicate efforts to monitoring their accounts on indexing bibliometric platforms.

Impact on Society.
This paper raises awareness of the barriers that ethnic scholars face in participating in the scientific community and being recognized for their contributions.

Future Research.
Future research can be built on this paper by expanding the size of the analytical samples and extending similar analyses on comparable data harvested from other bibliometric platforms.
Primer registro del Vireo Ojos Blancos, Vireo griseus, en Michoacán, México.
Authors: Díaz Infante Sergio , Torres García Ignacio
Published: July 2024

El registro de especies en nuevas localidades lejos de sus rangos típicos de distribución provee evidencia de movimientos y migraciones atípicos provocados por varios factores pobremente entendidos, por lo que su documentación contribuye a entender dichos movimientos. En México, el Vireo Ojos Blancos, Vireo griseus, se distribuye principalmente en la vertiente del Golfo, ya sea como residente o migratorio, y los registros en la vertiente del Pacífico son muy raros. En febrero de 2022, registramos un individuo en el humedal La Mintzita, cercano a Morelia, Michoacán. El individuo solitario se encontraba forrajeando y moviéndose constantemente entre densos arbustos debajo del dosel arbóreo, a 10 m del cuerpo de agua del manantial. Esta observación constituye el primer reporte formal para V. griseus en el estado de Michoacán. Este reporte aporta información sobre la distribución y movimientos de esta especie, y resalta el valor ecológico del humedal La Mintzita para aves residentes y migratorias.
DISCRETE OPTIMIZATION OF THE IMPLEMENTATION STAGES OF PHARMACEUTICAL DEVELOPMENT FOR A SPRAY TREATMENT FOR ORAL DISEASES
Authors: Shatalov D.O. , Kedik S.A. , Akhmedova D.A. , Gromakova A.I. , Koroleva Yu.A. , Dolgovskaya A.Yu. , Kharchenko S.M. , Kirillova D.D. , Minenkov D.S. , Nikulin A.V.
Published: July 2024

Introduction. All over the world more than 3.5 billion people suffer from oral diseases, which can lead to endogenous infectious diseases and create conditions for external infections. The growing antimicrobial resistance of bacterial strains is a global health threat. Oligoalkyleneguanidine polymers may be promising compounds to solve this problem. The spray form for the application of these substances is the most optimal. The aim of the study is to apply discrete optimization to implement the stages of pharmaceutical development of a spray based on branched oli-gohexamethyleneguanidine for the treatment of oral diseases. Material and methods. Experiments are carried out using various equipment and samples with different compositions have been developed. The implementation of the pharmaceutical development stages was carried out using a discrete optimization algorithm. Results. When implementing discrete optimization in pharmaceutical development, it is necessary to prioritize criteria and limitations using the target quality profile of the drug being developed. As a result of the optimization cycles carried out, the optimal composition was selected, which corresponds to the target quality profile, including such parameters as pH, dynamic viscosity, sterilizing filtration, adhesion of the formulations to the oral mucosa and the spray torch. A discrete optimization was carried out, taking into account the wetting edge angle and particle size distribution. The optimal com-position was sample No. 8, which has pseudoplastic properties, provides unhindered spraying and prevents the composition from draining from the mucous membrane of the oral cavity. Conclusion. During the study, the optimal ratio of components was determined and the development of a spray based on oligohexamethyleneguani-dine with the implementation of stages of pharmaceutical development for discrete optimization was proposed.
NEW ANTIMICROBIAL AGENTS IN THE DIHYDROXANTHONE SERIES: ESTABLISHMENT OF STRUCTURE-ACTIVITY RELATIONSHIPS AND STANDARDIZATION
Authors: Frolova V.V. , Krishtanova N.A. , Chernov N.M. , Gurina S.V. , Yakovlev I.P.
Published: July 2024

Introduction. Irrational use of antimicrobial drugs, chemical and biological agents leads to the emergence and spread of resistance in microorgan-isms. Therefore, there is an increasing need for the search and development of new antimicrobial compounds. Dihydroxanthone derivatives, which have a wide spectrum of action, are one of the promising groups of antimicrobial substances. New derivatives of 4,4a-dihydroxanthone were obtained at the St. Petersburg State Chemical and Pharmaceutical University (SPCFU) at the Department of Organic Chemistry. Synthetic 4,4a-dihydroxanthones are structurally similar to antimicrobial xanthones of natural origin – fomalevones A and C. Therefore, 4,4a-dihydroxanthones are promising compounds for the creation of new antimicrobial substances. Purpose of the study. To establish the relationship between the chemical structure of the synthesized dihydroxanthones and their antimicrobial ac-tivity and to standardize the active compound. Materials and methods. 20 new derivatives of 4,4a-dihydroxanthone were synthesized. The structure and identity of the compounds was estab-lished using physical and chemical methods of analysis. The antimicrobial activity of these derivatives was studied by double serial dilution method. Quality standards for the most promising compound 5-bromo-7-chloro-4,4-dimethyl-9-oxo-4,4a-dihydroxanthone (a17) were developed. Results. In preliminary studies, we found that 4,4a-dihydroxanthones synthesized in SPCFU have a pronounced effect against gram-positive bacteria. It was found, that the antibacterial activity of 4,4a-dihydroxanthone derivatives depended on their structure. The presence of substituents with acceptor properties led to an increase in activity, while donor substituents reduced the antimicrobial effect of the compounds. 5-Bromo-7-chloro-4,4-dimethyl-9-oxo-4,4a-dihydroxanthone (a17) turned out to be the most active compound, and we carried out its standardization for some indicators. Conclusions. During the study of the antimicrobial activity of the synthesized dihydroxanthones, it was found that they are active against gram-positive bacteria. The antibacterial activity of 4,4a-dihydroxanthone derivatives depends on their structure. Among them, the most active compound was identified – leader a17, which has a pronounced antistaphylococcal effect. Its standardization has been carried out for some indicators.
SUCCINATE-RECEPTOR SYSTEM OF BONE AND CARTILAGE TISSUE IN PATIENTS WITH METABOLIC PHENOTYPE OF OSTEOARTHRITIS
Authors: Shodiev D.R. , Zvyagina V.I. , Ryabova M.N. , Marsyanova Y.A.
Published: July 2024

Introduction. Currently, osteoarthritis (OA) has been identified as a polyetiological disease, where several phenotypes have been identified based on the leading frequency. Obviously, each clinical phenotype corresponds only to its fundamental changes on the part of various organs and systems. Un-til recently, special attention was paid to the study of metabolic processes in osteoarthritis (OA) and was paid to the state of the cartilage, but more and more interest was focused on the biochemistry of the subchondral bone, its microarchitectonics and signal function. Aid. To study the features of the manifestation of the succinate-receptor system of bone and cartilage tissue in patients with the metabolic phenotype of osteoarthritis. Material and methods. 42 patients took part in the study and were divided into 2 groups: 1 group – patients without articular disease, normal body mass index; 2 group – patients with metabolic phenotype of OA. The subjects were collected complaints, anamnesis, as well as general clinical and orthopedic examination. The levels of succinate, succinate receptor (SUCNR1) and succinate dehydrogenase (SDH) are measured in bone and cartilage tissue homogenates. Results. In the 2 group, an increase in SUCNR1 expression was detected in all studied areas of the joint in comparison with the 1 group. In the 2 group, the differences were tissue-specific in the distribution of SUCNR1 with a predominant increase in the amount of the receptor in the subchondral bone compared to the loaded (p=0.031) and non-loaded zone of cartilage (p=0.001). In the 1 group, the studied areas of cartilage and bone did not dif-fer in the amount of SUCNR1 from each other. In the group of patients with the metabolic phenotype of OA, an increase in mitochondrial succinate was found both in the subchondral bone tissue and in different zones of cartilage compared to the 1 group. The final indicators of SDH activity in the mito-chondria of the studied joint zones that we obtained turned out to be low in both groups, however, relatively high enzyme activity was observed in the subchondral zone of the bone of the group of metabolic phenotype of OA. Conclusion. In patients with the metabolic phenotype of OA, high expression of SUCNR1 in joint tissues is observed, which is tissue-specific with a predominant increase in the amount of SUCNR1 in the subchondral bone. We found higher levels of succinate in the subchondral bone and cartilaginous areas of joints in patients with the metabolic phenotype of OA and suggest that the succinate-SUCNR1 interaction in affected joints in OA is adaptive in nature.
IMMUNOMODULATING ACTIVITY OF INDIVIDUAL SUBSTANСES ISOLATED FROM THE AERIAL PART OF RHAPONTICUM UNIFLORUM (L.) DC IN EXPERIMENTAL IMMUNODEFICIENCY
Authors: Khobrakova V.B. , Tugarina Yu.A. , Olennikov D.N. , Pavlova S.I.
Published: July 2024

Introduction. The development and introduction of new drugs with immunomodulatory effects is one of the priorities of modern medicine. Numerous studies have proven the immunotropic activity of individual substances isolated from medicinal plants (flavonoids, phenylpropanoids, polysaccharides, ecdysteroids, terpenoids, etc.). In this study, it is of interest to determine the immunomodulatory effect of individual substances isolated from Rhaponticum uniflorum (L.) DC. The purpose of the study. Determine the immunomodulatory properties of 20-hydroxyecdysone, 5-О-caffeoylquinic acid and arabino-3,6-galactan, isolated from the aerial part of Rhaponticum uniflorum (L.) DC, in relation to the cellular and humoral components of the immune response during exper-imental immunosuppression caused by cyclophosphamide. Material and methods. The experiments were performed on 100 male mice of the F1 line (CBAxC57Bl/6) weighing 18-20 g. Immunodeficiency was simulated by in traperitoneal administration of cyclophosphamide at a dose of 250 mg/kg once. The experimental group of animals received individual substances intragastricallyin the following doses: 5-О-caffeoylquinic acid - 10 mg/kg, arabino-3,6-galactan - 10 mg/kg, 20-hydroxyecdysone - 3 mg/kg, once a day for 14 days. The intact group of mice received purified water according to the analogous scheme. The state of humoral chain of the im-mune response was estimated according to the quantity of antibody-forming cells (AFC) determined with the use of Cunningham's plaque assay (1965). The state of the cellular chain of the immune response was estimated according to the delayed hypersensitivity reaction. Study results. It has been established that 20-hydroxyecdysone, 5-О-caffeoylquinic acid and arabino-3,6-galactan, isolated from the aerial part of Rhaponticum uniflorum (L.) DC, have immunomodulatory effect on the cellular and humoral components of the immune response in immunosuppres-sion caused by cyclophosphamide. Conclusions. The obtained results argues the feasibility of further research of individual substances, isolated from the aerial part of Rhaponticum uni-florum (L.) DC, with a view to creating new effective immunomodulators of plant origin.
PROBLEMS OF DETERMINING THE MEDICINAL HERBAL REMEDIES ANTIMICROBIAL ACTIVITY AND THEIR SOLUTION METHODS
Authors: Timokhina A.S. , Lupanova I.A. , Mizina P.G. , Fateeva T.V.
Published: July 2024

Intriduction. Currently, the antibiotic resistance development in pathogenic microorganisms remains a global problem. To solve this problem, an active search and development of new antimicrobial drugs, including those of plant origin, is underway. In the many years course of experience in this area, methods used to determine antimicrobial activity are being developed and improved, however, not all of them are suitable for determining the activity of biologically active substances of plant origin. The purpose of the study. To summarize information about existing methods for determining antimicrobial activity under in vitro experimental conditions. Material and methods. The article is based on publication materials from the PubMed and E-library databases, search.rsl. The literary search was carried out by keywords: antimicrobial activity, antibacterial effect, antibiotic, herbal preparations. The review includes articles that are relevant to the research topic and have been published over the past 10 years. Results and discussion. The article describes the main methods for determining antimicrobial activity in vitro and determines the possibility of using these methods in relation to herbal remedies. Conclusions. The findings indicated that the choice of the research method should depend primarily on the object under study and the type of microorganism in respect of which the activity is determined. Most of the developed and widely used methods for determining antimicrobial activity do not allow an adequate assessment of the activity of herbal remedies. Thus, when working with herbal remedies, the methods of double serial dilutions in liquid nutrient media with the use of indicators and the developing direction of activity research on biofilms can be considered the most accurate.
INFLUENCE OF CULTIVATION CONDITIONS ON THE GROWTH AND ACCUMULATION OF BIOLOGICALLY ACTIVE SUBSTANCES OF HYSSOPUS OFFICINALIS L. UNDER IN VITRO CONDITIONS
Authors: Cherednichenko M.Yu. , Khlebnikova D.A. , Fedotova P.A. , Brem E.S. , Romanenko V.A.
Published: July 2024

Introduction. Since ancient times, aromatic plants have been widely used to treat diseases of various natures due to the content of valuable metab-olites and essential oils (EOs). In modern medicine, cosmetology and the food industry, the importance of aromatic plants is also not in doubt; the chemical composition, accumulation features, synthesis and properties of EO are being actively studied. With the development of clonal micropropaga-tion technology, it has become relevant to study the accumulation of biologically active substances in aseptic in vitro culture (microclones and cell cul-tures) under various propagation protocols. Material and methods. Hyssop (Hyssopus officinalis L.) is a common aromatic plant from the family Lamiaceae Martinov. The aerial parts and EO of the plant have a wide range of biological activities - anti-inflammatory, antioxidant, antimicrobial, etc., which determines the use of plant biomass and extracts in food and light industries, medicine, and pharmacology. In this work, the influence of the mineral and hormonal composition of nutrient me-dia on the growth of aseptic plants of two cultivars of Hyssopus officinalis – Lekar and Iney – was studied. Results and conclusion. A comparison was also made of the accumulation of the total flavonoids in an aseptic culture depending on the cultivation mode - the degree of aeration of the culture vessel and the addition of cytokinin or auxin components to the nutrient medium. It was found that the leaves of aseptic plants of Hyssopus officinalis accumulate more flavonoids (up to 3.6 mg/g fresh weight) than the stems (0.3–1.1 mg/g fresh weight for most experimental variants), in addition, the cv. Lekar was significantly richer in compounds of this group (2.7–3.6 mg/g fresh weight in leaves) compared to the cv. Iney (no more than 1.5 mg/g fresh weight in leaves).
KUALITAS PROSES AUDIT: TASK COMPLEXITY DAN LOCUS OF CONTROL DENGAN TABK SEBAGAI MODERASI
Authors: Elina Jelita Frisca , Darmastuti Dewi
Published: July 2024

The COVID-19 pandemic has driven significant transformations in audit practices, particularly through the shift towards remote auditing. The focus of this research is to examine the influence of Task Complexity and Locus of Control on Audit Process Quality with Computer-Assisted Audit Techniques (CAAT) as a moderating variable. This study employs a quantitative research method with primary data collection through questionnaires and Likert scales. The research sample consists of 100 auditors working in Public Accounting Firms in DKI Jakarta, selected using purposive sampling method. Data analysis is conducted using Structural Equation Modeling (SEM) through the SmartPLS 4.0 program with a significance level of 0.05. Findings indicate that Task Complexity has a significant negative impact on Audit Process Quality, while Internal Locus of Control has a significant positive influence. Conversely, External Locus of Control does not significantly affect Audit Process Quality. CAAT as a moderating variable weakens the relationship between Task Complexity and Audit Process Quality. However, CAAT does not strengthen the relationship between Internal Locus of Control and Audit Process Quality, and it does not influence the relationship between External Locus of Control and Audit Process Quality. The implications of this research lie in a more comprehensive understanding of components influencing audit process quality, contributing to the enhancement of audit practices in the digital era.
Pengaruh Struktur Kepemilikan dan Ukuran Perusahaan Terhadap Kinerja Intellectual Capital
Authors: Nicma Hanifa Ainun , Tumirin
Published: July 2024

The focus of the research is how a company's ownership structure and size impact intellectual capital. This research uses multiple linear regression and purposive sampling to examine 37 companies listed on the Indonesia Stock Exchange (BEI) in 2022. Intellectual capital is not affected by company size, institutional ownership, or foreign ownership; however, management ownership influences 5%. Those who wish to conduct further research can use this research as a reference regarding ownership structure and company size on intellectual capital performance.
Reversão de situações próximas ao pleno emprego e ataques aos direitos sociais: os casos dos países centrais ao final da Era de Ouro e do Brasil na década de 2010
Authors: Oliveira Bruno Rodas , Barros Luciano Alencar
Published: July 2024

O presente artigo busca apresentar um arcabouço teórico a respeito de como as mudanças socioeconômicas geradas a partir de situações próximas ao pleno emprego engendram respostas políticas (econômicas e institucionais) das classes dominantes no intuito de revertê-las, e usá-lo para analisar a experiência concreta dos países capitalistas centrais no fim da Era de Ouro e do Brasil na década de 2010. Ressalvadas as particularidades de cada país, tanto num caso como no outro a manutenção por um período significativo de baixas taxas de desemprego com elevados ganhos salariais e sociais gerou pressões crescentes dos setores dominantes pela adoção de políticas econômicas contracionistas e reformas institucionais regressivas, que eventualmente resultaram no aumento das taxas de desemprego, redução do poder de barganha da classe trabalhadora e, a partir disso, na retração dos salários reais e outros benefícios sociais.
A crise da Nova República e a ascensão autoritária no Brasil
Authors: León Jaime Ernesto , Malta Maria Mello de
Published: July 2024

O artigo analisa a controvérsia em torno da crise da “democracia de cooptação” na “Nova República” brasileira, um momento histórico iniciado com a Constituição de 1988 e que está em crise desde 2015. A conclusão aponta que esta forma de democracia foi construída como uma solução burguesa para a crise da ditadura de 1964-1985 e, ironicamente, somente através de um partido político (Partido dos Trabalhadores) comprometido originalmente com a questão trabalhista e que passara por um processo de “transformismo” é que a democracia de cooptação poderia ser desenvolvida nos seus aspectos mais extremos. Este modelo está desgastado e deu origem ao momento autoritário sob o governo Bolsonaro.