bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent advancements in traditional Chinese medicine for COVID-19 with comorbidities across various systems: a scoping review
Authors: Shang Xiyu , Cao Yuqing , Guo Yang , Zhang Lei , Li Jiajia , Zhang Huifang , Fan Yipin , Huang Yuxuan , Li Jiantao , Wang Yanping , Xiong Yibai , Cai Qiujie , Zhang Huamin , Ma Yan
Published: December 2024

Background

Traditional Chinese medicine (TCM) has developed a rich theoretical system and practical experience in fighting to infectious diseases over the past thousands of years, and has played an important role in controlling the spread owing to its unique advantages. In particular, its significant contribution to the prevention and control of Corona Virus Disease 2019 (COVID-19) is widely recognized. COVID-19 infection is mainly non-severe with a favorable overall outcome, but patients with comorbidities tend to have a poor prognosis. However, a comprehensive review of TCM for preventing and treating COVID-19 with comorbidities across various systems is still lacking. Hence, this scoping review aims to conduct a comprehensive investigation on treatment outcome of TCM for treating COVID-19 with comorbidities across various systems.

Methods

The scoping review was conducted by searching English databases including PubMed and Web of Science, and Chinese databases including China National Knowledge Infrastructure and Wanfang between January 2020 and January 2024. We followed the inclusion and exclusion criteria to identify relevant literature. Information for inclusion in the literature were subsequently extracted and consolidated.

Results

We enrolled 13 literature that met the inclusion criteria in the review finally. Our analysis revealed that research on COVID-19 with comorbidities was mostly focused on circulatory diseases, including hypertension, heart failure, and cerebrovascular diseases, most common comorbidities were hypertension. Followed by endocrine and metabolic diseases such as diabetes, respiratory diseases including pulmonary tuberculosis and chronic obstructive pulmonary disease have been also addressed. However, there were few studies on co-infectious urogenital system disease, and no studies on the rheumatic, immune, hematological, nervous, reproductive, and skin systems diseases. Based on existing studies, TCM has significantly improved the clinical symptoms of COVID-19 with comorbidities such as fever, fatigue, dry cough, anorexia and asthma, the absorption of lung lesions, shortened the duration of viral shedding and the course of disease.

Conclusions

TCM has great application prospects in treating COVID-19 with comorbidities. These findings could provide important evidence for clinicians to treat COVID-19 with comorbidities. Multi-center studies are required to confirm our results in the future.

Graphical Abstract
Material hardship and secure firearm storage: findings from the 2022 behavioral risk factor Surveillance System
Authors: Testa Alexander , Henson-Garcia Mike , Jackson Dylan B. , Fu Karyn , Ganson Kyle T. , Nagata Jason M.
Published: December 2024

Background

Firearm secure storage is an important public health practice due to its potential impact on reducing the incidence of accidental injuries, suicides, and thefts. Yet, there is limited research on how economic conditions might shape firearm storage patterns.

Methods

This study explores the relationship between material hardship and firearm secure storage among firearm-owning households. Data from the 2022 Behavioral Risk Factor Surveillance System (BRFSS) were analyzed, including responses from 7,197 firearm-owning adults in California, Minnesota, Nevada, and New Mexico. Multinomial logistic regression models assessed the relationship between levels of material hardship and storage practices, adjusting for demographic and socioeconomic factors.

Results

Among respondents, 14.3% reported firearms were stored, loaded and unlocked. Compared to respondents experiencing no hardships, those experiencing three or more material hardships incurred a 183% higher risk of storing firearms in an unsecured manner (Relative Risk Ratio = 2.828, 95% CI = 1.286, 6.220).

Conclusion

This study highlights an association between greater material hardship and unsecured firearm storage. These findings emphasize the need for public health interventions that address economic barriers to safe firearm storage, potentially reducing firearm-related injuries and deaths among individuals experiencing material hardship.
Are we cultivating the perfect storm for a human avian influenza pandemic?
Authors: Perez-Acle Tomas , Ravello Cesar , Rosemblatt Mario
Published: December 2024

The emergence of highly pathogenic avian influenza (HPAI) A H5N1 virus in dairy cattle marks a troubling new chapter in the ongoing battle against zoonotic diseases. Since its initial detection in 1955, the H5N1 virus has primarily been associated with poultry, posing significant threats to both animal and human health. However, recent outbreaks in U.S. dairy herds across nine states have revealed an alarming expansion of the virus, with over 190 herds affected as of September 2024. This unprecedented spread in cattle has sparked intense concern among scientists and health officials, especially with reports indicating that up to 20% of dairy products may contain traces of the virus. The implications of the H5N1 virus establishing itself in cattle populations are profound. This potential endemic presence could transform dairy farms into reservoirs of the virus, facilitating its evolution and increasing the risk of human transmission. Mutations enhancing viral replication in mammals have already been identified, including the notorious PB2 E627K mutation linked to increased virulence. Moreover, the detection of the virus in the central nervous system of infected animals, including cats, underscores the broad tissue tropism and severe pathogenic potential of the H5N1 virus. Current containment efforts include stringent biosecurity measures and financial incentives for enhanced testing and personal protective equipment (PPE) for farmers. Yet, gaps in testing infrastructure and the resurgence of raw milk consumption pose significant challenges. The U.S. Department of Agriculture (USDA) and the Centers for Disease Control and Prevention (CDC) emphasize the critical need for comprehensive testing and pasteurization to mitigate the risk of human infection. As the scientific community races to adapt existing antiviral treatments and develop effective vaccines, the concept of a One Health approach becomes increasingly vital. This holistic strategy calls for coordinated actions across human, animal, and environmental health sectors to preemptively tackle emerging zoonotic threats. Strengthening surveillance, fostering international cooperation, and investing in research are essential steps to prevent the H5N1 virus from igniting the next global health crisis. The current avian influenza outbreak serves as a stark reminder of the delicate balance between human activities and viral evolution. Our collective ability to respond effectively and proactively will determine whether we can avert the perfect storm brewing on the horizon.
Differential cardiac impacts of hematological malignancies and solid tumors: a histopathological and biomarker study
Authors: Udin Michael H. , Sunder Sunitha Shyam , Nepali Sarmila , Kattel Sharma , Abdelradi Amr , Doyle Scott T. , Ionita Ciprian N. , Liu Qian , Sharma Umesh C. , Pokharel Saraswati
Published: December 2024

Background

Cancer patients are known to be associated with increased risk of cardiovascular disease. However, no studies have examined the differential impact of hematologic malignancies (HMs) and solid tumors (STs) on cardiac morphology at the tissue level.

Objective

We aimed to examine histopathological features alongside cardiovascular biomarkers in patients with HMs and STs who underwent post-mortem evaluation.

Methods

We analyzed cardiac changes in 198 patients with HMs and 164 patients with solid tumors STs. We compared demographics, echocardiogram data, exposure to various antineoplastic agents, and post-mortem findings. Additionally, cardiac histological validation was conducted on post-mortem cardiac specimens to examine cardiac tissue morphology, focusing on cardiomyocyte nuclear density, collagen content, and collagen fiber orientation.

Results

HM patients displayed significantly disordered collagen fiber alignment (0.71 vs 0.83, P = 0.027), and reduced cardiomyocyte nuclear density (56 vs 72, P = 0.002) compared to ST patients. Similarly, hemoglobin level was decreased (6.71 vs 8.06, P < 0.001) in HM patients compared to ST patients. HM patients also showed elevated B-type natriuretic peptide levels (2,275 vs 867, P < 0.001), without significant differences in creatine-kinase MB and cardiac troponin levels. Multivariate analysis identified increased right ventricular thickness, low diastolic blood pressure, and high cardiac troponin levels as risk factors for cardiac death in HM patients.

Conclusions

This study demonstrates that HM patients have fewer cardiomyocyte nuclei and poorly aligned collagen, with serum biomarker evidence of increased cardiac dysfunction. This supports the necessity for specialized cardiac care for these patients.
Cardiovascular mortality trends and disparities in U.S. breast cancer patients, 1999–2020: a population-based retrospective study
Authors: Yeo Yong-Hao , San Boon-Jian , Tan Jia-Yi , Tan Min-Choon , Donisan Teodora , Lee Justin Z. , Franey Laura M. , Hayek Salim S.
Published: December 2024

Background

Breast cancer survivors face a higher risk of cardiovascular disease (CVD) compared to non-breast cancer patients, yet contemporary data on CVD-related mortality within this group remains scarce.

Objective

To investigate trends and disparities in CVD mortality among breast cancer patients.

Methods

We queried the Centers for Disease Control and Prevention’s Wide-Ranging Online Data for Epidemiologic Research (CDC Wonder) and conducted serial cross-sectional analyses on national death certificate data for CVD mortality in breast cancer patients aged 25 and above from 1999 to 2020. We calculated age-adjusted mortality rates (AAMR) per 100,000 individuals and analyzed trends over time using the Joinpoint Regression Program, with further analyses stratified by age, race, census region, and urbanization level.

Results

A total of 74,733 CVDs with comorbid breast cancer in the United States were identified between 1999 and 2020. The AAMR from CVDs with comorbid breast cancer decreased from 2.57 (95% CI [2.50–2.65]) in 1999 to 1.20 (95% CI [1.15–1.24]) in 2020, with an average annual percent change (AAPC) of − 4.3. The three most common causes of CVDs were ischemic heart disease (47.8%), cerebrovascular disease (17.1%), and hypertensive disease (10.6%). Our analysis revealed a significant decrease in AAMR for all CVD subtypes, except for hypertensive diseases and arrhythmias. The decrease in annual percent change (APC) was more pronounced in individuals aged ≥ 65 years compared to those < 65 years (-4.4, 95%CI [-4.9, -3.9] vs. -2.9, 95%CI [-4.1, -1.7], respectively. Notably, non-Hispanic Blacks consistently exhibited the highest AAMR (1.95, 95%CI [1.90–1.99]), whereas Hispanic or Latina patients had the lowest AAMR (0.75, 95% CI [0.72–0.78]). The AAMR was also higher in rural regions than in urban areas (1.64, 95%CI [1.62–1.67] vs. 1.55, 95%CI [1.53–1.56]).

Conclusion

The study highlights a significant decline in CVD mortality among breast cancer patients over two decades, with persistent disparities by race and region. Exceptionally, hypertensive diseases and arrhythmias did not follow this declining trend.
Role of International Academy of Cytology Yokohama reporting system in breast lesions at tertiary care centre in Central India
Authors: Verma Deepshikha , Newaskar Vedanti , Balani Sharda , Malik Reeni , Khan Arshi
Published: December 2024

Background

The International Academy of Cytology (I.A.C.) Yokohama System to report breast cytopathology can effectively categorize breast diseases into different cytological groups. Fine needle aspiration (FNAC) from the lesions in the breast has been regarded as a major method of diagnosing breast cancer, particularly in rural settings. The major purpose of this study was to validate the diagnostic accuracy of breast FNA utilizing the IAC Yokohama system in future endurances. Histopathological examination is considered the gold standard for diagnosing benign as well as malignant breast lesions and is compared with FNA results.

Material and methods

Research on patients getting a core-needle, incisional, or excisional biopsy of breast lesions between January 1st, 2021, and December 31st, 2021, was conducted at a tertiary care center in central India. 216 breast FNAs were recorded utilizing the IAC Yokohama system, and the most appropriate category was assigned for every case and correlated with histopathology to evaluate the effectiveness of IAC system.

Results

The new "International Academy of Cytology (IAC) Yokohama system" was used to categorize 216 patients into five categories based on the cytologic diagnosis.

Those were C1: insufficient material (8.7%), C2: benign (65.7%), C3: atypical (1.8%), C4: suspicious of malignancy (2.7%), and C5: malignant (20.8%). FNACs were associated with ancillary testing and histological diagnosis to examine diagnostic accuracy. The overall Specificity, sensitivity, negative predictive value, positive predictive value, and accuracy were calculated with the risk of malignancy.

Conclusion

With high specificity and sensitivity for each type of situation, for all tumors, and for each analyzed BI-RADS category, the IAC Yokohama system provides excellent accuracy for breast FNA .
Triple coronary thrombosis: autopsy case and literature review
Authors: Gedich Ekaterina , Waters David M. , Gitto Lorenzo
Published: December 2024

Triple coronary artery thrombosis is a rare cause of acute myocardial infarction, and is associated with high mortality. Only a few cases of simultaneous multiple-vessel coronary thrombosis have been reported in the medical literature. This paper reports a unique case of sudden cardiac death in 36-year-old man without relevant risk factors who suffered from acute myocardial infarction due to simultaneous triple coronary artery thrombosis. Autopsy and histopathology examinations revealed near-total thrombotic occlusion in all three main coronary arteries. While the exact mechanism behind the simultaneous formation of these thrombi remains unclear, this paper discusses certain risk factors that may contribute to multiple coronary thrombosis. A review of previously reported cases of coronary thrombosis involving all three major coronary arteries in the literature is also provided to contribute to the understanding of this rare and potentially fatal condition. Obtaining a detailed medical and family history, collecting and saving blood samples for potential genetic analyses, and testing for Novel Coronavirus disease could be beneficial in cases of multiple coronary artery thrombosis to detect a potential underlying cause and provide prevention to family members at risk.
Alterations in the metabolic signature of full-term infants of diabetic mothers
Authors: Awad Hesham A. , Gad Ghada I. , Khalifa Ola A. , Ibrahim Amal A. , Shinkar Dina M.
Published: December 2024

Background

Maternal diabetes during pregnancy may alter the metabolomic profile of the offspring, increasing the risk of perinatal complications and potentially predisposing them to adverse metabolic consequences during later life. To assess this risk, we aimed to study the levels of amino acids and acylcarnitines in the cord blood of infants of diabetic mothers (IDMs).

Methods

Fifty term-IDMs were compared to 25 healthy newborns. Of the diabetic mothers, 37 had gestational diabetes mellitus (GDM), and 13 had pre-gestational diabetes mellitus (PGDM). Amino acid and acylcarnitine concentrations were measured in dried spot samples of cord blood using ultra-performance liquid chromatography–mass spectrometry (UPLC-MS).

Results

We observed significantly higher levels of valine, aspartic acid, the leucine-to-isoleucine (Leu:Ile), and leucine-to-phenylalanine (Leu:Phe), and decreased values of methionine and the phenylalanine-to-tyrosine (Phe:Tyr) in neonates in the GDM group compared to controls. Neonates of mothers with GDM showed higher levels of C2-carnitine, C5-carnitine, C5:1, and C4-OH (C3-DC) compared to controls. Neonates of mothers with PGDM also showed higher levels of C2-carnitine, C0-carnitine, and C5:1 compared to controls. There were no significant differences in amino acids or acylcarnitine levels between IDMs with GDMs and PGDMs. Principle component analysis (PCA) showed that principal component 1 (PC1) was responsible for the majority of differences between IDMs and controls. PC1 consisted of aspartic, valine, leu:lle, C4-OH(C3-DC), C2-carnitine, C0-carinitine, C5-carnitine, C18:1, and C16:1. Variable importance in projection (VIP) scores based on PLS-DA loadings showed high values for aspartic, valine, leu:lle, Leu:Phe, C4-OH(C3-DC), C2-carnitine, C0-carnitine, C5:1, C5-DC, C18:1, C16:1, C5-carnitine in IDMs, and high values for Met:Phe, methionine, and Phe:Tyr in controls.

Conclusion

Maternal diabetes leads to alterations in amino acid concentrations and the carnitine shuttle pathway of their offspring.
Long-Term Follow-Up and Overall Survival in NRG258, a Randomized Phase III Trial of Chemoradiation Versus Chemotherapy for Locally Advanced Endometrial Carcinoma
Authors: Matei Daniela E. , Enserro Danielle M. , Randall Marcus E. , Mutch David , Small William , DiSilvestro Paul A. , Spirtos Nick M. , O’Malley David M. , Cantuaria Guilherme H. , Michelin David , Waggoner Steven , Shahin Mark , Guntupalli Saketh , Lara Olivia , Ueland Frederick R. , Warshal David , Bonebrake Albert , Tewari Krishnansu S. , Tan Annie , Powell Matthew A. , Walker Joan L. , Santin Alessandro D. , Kim Jong Hyeok , Miller David S.
Published: December 2024

This randomized phase III trial aimed to determine whether treatment with cisplatin and volume-directed radiation followed by carboplatin and paclitaxel for four cycles (chemoradiotherapy [C-RT]) increased recurrence-free survival (RFS) and overall survival (OS) when compared with carboplatin and paclitaxel for six cycles (chemotherapy [CT]) in locally advanced endometrial cancer (UC). Previously reported results showed that C-RT did not improve RFS compared with CT. Here we report the final OS analysis. Patients with International Federation of Gynecology and Obstetrics (FIGO) 2009 stage III-IVA UC or stage I/II serous or clear cell UC and positive cytology were enrolled. The primary objective was RFS. Secondary objectives were OS, toxicity, and quality of life. Cumulative probabilities of OS were estimated using the Kaplan-Meier method. Subgroup analyses of treatment effect for FIGO stage, age, race, gross residual disease, histology, lymph-vascular space invasion, and body mass index were performed. In total, 813 patients were randomly assigned (407 C-RT and 406 CT). The median follow-up was 112 months. Median OS was not achieved in either arm. The stratified hazard ratio for death comparing C-RT versus CT was 1.05 (95% CI, 0.82 to 1.34, log-rank two-sided
P
value = .72). None of the factors analyzed predicted OS benefit from C-RT. Although C-RT reduced the rate of local recurrence compared with CT, it did not increase OS or RFS in stage III/IVA UC.
Bioanalytical Method Comparison Strategy for Clinical Anti-drug Antibody Immunoassays
Authors: Elliott R. J. , Pourmohamad T. , Webb-Vargas Y. , Yan W. , Nijem I. , Siguenza P. , Song Y.
Published: December 2024

Per FDA guidance, method comparability should be established if an anti-drug antibody (ADA) assay is run by two or more independent laboratories during a study. Genentech, Inc. is evaluating an immunogenicity risk-based comparability approach consisting of both technical and clinical aspects. Technical comparability of the relative sensitivity (RS) is assessed using the Two One-Sided T-tests (TOST) statistical analysis which evaluates if the difference (in absolute value) of the RS means of the two laboratories is less than a pre-specified level of comparability, the practically significant difference (PSD). Clinical comparability is based on the molecule’s immunogenicity risk. A basic and in-depth assessment for low and high-risk molecules are used, respectively. An alternative strategy for molecules with limited incurred sample availability is to be used. In the basic assessment, samples are either unfortified or fortified with surrogate ADA positive control at method appropriate concentrations in a representative biological matrix. Acceptable comparability requires in both methods i) at least 80% of the unfortified samples screen and confirm negative, ii) at least 90% of the low concentration samples screen and confirm positive; and iii) 100% of the high concentration samples screen and confirm positive. The in-depth assessment uses at least 100 incurred samples from 30 or more ADA-positive and ADA-negative patients. The results are evaluated using a 2 by 2-confusion matrix and Cohen’s Kappa score where 1 indicates perfect agreement. Acceptable comparability requires a Cohen’s Kappa score of greater than 0.40. This strategy allows for a robust technical and clinical method comparability assessment.

Graphical Abstract
The Self-Fashioned Writer’s “Confession”
Authors: Stenstrom Ellen
Published: December 2024

This article brings together two literary icons of personal “confessional” writing, Sylvia Plath and Margery Kempe, to examine—among their other uncanny transhistorical similarities—the way in which both women consciously self-fashioned their personhoods and their afterlives as writers and public figures. It also examines the ethically and affectively complicated dynamics of archival engagement with such fraught figures, reflecting on the author’s own relationship to Plath and the way it has shaped her training as a literary academic. Ultimately, she sees Plath and Kempe as women who dared to “[think their] own story might be meaningful” by actively shaping themselves with the texts they were reading; this not only invites devoted readers to do the same but also suggests that a more confessional mode of criticism may actually be a more ethical way of encountering archives and ethically fraught writers.
No God but Man
Authors: Husain Atiya
Published: December 2024

Reconceptualizing the relationship between race and Islam in the United States, No God but Man theorizes race as an epistemology using the FBI’s post-9/11 Most Wanted Terrorist list and its posters as its starting point. Atiya Husain traces the origins of the FBI wanted poster form to the work of nineteenth-century social scientist Adolphe Quetelet, specifically his overvalued type of human called “average man.” Husain argues that this notion of the human continues to structure wanted posters, as well as much contemporary social scientific thinking about race. Focusing on the curious representations on the Most Wanted Terrorist list that range from Muslims who lack a race category on their posters to the 2013 addition of Black revolutionary Assata Shakur, Husain demonstrates the ongoing influence of the average man and its relevance even today, proposing a counterweight to the category by engaging Shakur’s turn to Islam in the 1970s in the legal context. In doing so, Husain shows the limitations of race as an analytical category altogether.
Monitoring spatiotemporal changes in global change drivers and their effects on semiarid woodlands and forests - fieldwork protocol
Authors: Branquinho Cristina , Rocha Bernardo , Ullah Sami , Oliveira Maria Alexandra , Vanguelova Elena , Serrano Helena , Nunes Alice , Principe Adriana , Pinho Pedro , Munzi Silvana , Monteiro Juliana , Alonso Rocío , Gharun Mana , Guerrieri Rossella
Published: December 2024

Training schools play a vital role in COST actions, particularly for young researchers, as they provide opportunities to visit international laboratories and learn new methodologies. In May 2024, CLEANFOREST organized its first training school, Monitoring Spatiotemporal Changes in Global Change Drivers and Their Effects on Semiarid Woodlands and Forests, held at the Faculty of Science of the Universidade de Lisboa. The training school included a field trip designed to explore global change drivers and their impacts on semiarid woodlands and forests. Participants engaged in hands-on activities to understand how forest ecosystems interact with key global change factors such as air quality and climate change. They were introduced to various monitoring techniques and parameters for assessing forest health, including ecosystem fluxes, tree physiology, mortality, and regeneration. Additionally, participants examined plant biodiversity and functional ecology, focusing on lichens and their connection to air quality. Soil-related topics, such as the characterization of forest soils and their physico-chemical properties, were also addressed. Participants applied these methodologies in real-world scenarios, conducting measurements in different grazing management settings to assess their effects on tree growth, biodiversity, and soil properties. They then processed and analyzed the collected data, synthesizing their results to develop recommendations for sustainable forest management in the context of global change. This paper presents the field trip protocol used at Companhia das Lezírias, where simplified versions of established methodologies for sampling various ecosystem components were employed. The protocol provides a valuable reference for replicating similar studies, ensuring consistency in methodologies for future training and monitoring efforts.
Formation of Ideas about Family Values in Primary Schoolchildren in the Lessons of the Surrounding World
Authors: Artyuhova I.
Published: December 2024

The article presents methodological developments of lessons on “The World Around Us” for the second grade. In the Year of the Family in Russia, lessons on the topic of continuity of generations and preservation of traditional family values are especially relevant: “Love and loyalty in the family: from the depths of centuries to the present day”; “What is a family? How many generations are there in a family?” The lessons are compiled in accordance with the Federal Educational Program of Primary General Education and are aimed at forming primary positive ideas about family values in younger schoolchildren.
Meta-Subject Achievements of Primary Schoolchildren and Teacher Competencies
Authors: Zemlyanskaya Elena , Rydze Oxana , Udras A.
Published: December 2024

The article discusses the problem of updating such an aspect of training a primary education teacher as the development of professional competence in the formation of meta-subject achievements of students. The main ideas of the new university discipline “Methodology for the formation of meta-subject educational results of students in primary school” are considered. The content of the discipline, the features of the organization of theoretical training and practice at school are characterized, individual methodological techniques of the teacher’s work are revealed. The results of approbation of the discipline in the process of implementing educational programs for training a primary education teacher at the university are analyzed, the range of competencies that can be mastered by students in the course of obtaining basic higher education is highlighted.
Theory of public administration
Authors: Ponkin Igor'
Published: December 2024

The innovative author's textbook of a new generation on the theory of public administration outlines and explains the theoretical and normative foundations, key axioms, concepts and paradigms of this theory, ontology, organization features, subject-object composition, tools and technologies, process, problems of legal support, planning and implementation of public administration. The level of presentation is difficult.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is intended for undergraduates in the areas of training 38.04.04 "State and Municipal Administration" and 40.04.01 "Jurisprudence", for relevant specialty programs, students of Master of Public Administration (MPA) programs, as well as for relevant specialties, for graduate students and doctoral students, lawyers, managers, management personnel.
Modeling the Process of Combined Irrigation Using Electrochemically Activated Water in Greenhouses
Authors: Gribanov A. , Mescheryakova Anna , Starikov Aleksandr
Published: December 2024

The article discusses the modeling of the combined irrigation process using electrochemically activated water in greenhouses. It is proposed to maintain the greenhouse microclimate using an automated control system, which includes a programmable logic controller and specialized sensors for measuring pH levels, soil moisture and temperature, as well as air temperature and humidity. Drip irrigation and misting systems are used for watering. Electrochemically activated water, containing catholyte and anolyte, is used as irrigation water. To assess the influence of catholyte on soil pH, an experiment was conducted in which the pH level was measured in various soil layers (0-10 cm, 10-25 cm, 25-40 cm, 40-55 cm) over a period of 144 hours. The obtained data were analyzed, and a computer program was developed based on them, simulating the changes in soil pH levels in the greenhouse using a second-order aperiodic model with delay and a neural network model. Both models demonstrated high accuracy in predicting soil pH changes, which was confirmed by the calculated determination coefficient R². The irrigation model using catholyte, developed in MatLab/Simulink, reproduced the transient process of soil pH changes, confirming the adequacy of the experimental data. The research results showed that the use of catholyte significantly affects soil acidity, while not significantly altering soil moisture and the air humidity levels in the greenhouse
Developing Educational Environment: Concept and Basic Principles
Authors: Strokova E.
Published: December 2024

The article analyzes the features of the formation of a developing educational environment in the context of digital transformation. The importance of this process is determined by a number of factors, the most important of which is the rapid development of information technologies and their introduction into all spheres of society, including the educational process. A key role in this process is played by the formation of a developing educational environment capable of adapting to the individual characteristics and needs of each student, while ensuring his comprehensive development and preparation for effective functioning in a changing world. One of the key characteristics of such an environment is its focus on the individual needs and interests of each student. It is important that the educational environment takes into account different learning styles, which allows each child to reach their potential. The developing educational environment plays a key role in shaping the personality and ability of students to adapt and self-development. It creates conditions for active cognition, stimulating curiosity and critical thinking. The importance of such an environment lies in its ability to integrate theoretical knowledge with practical experience, which contributes to a deep understanding of the educational material. Another feature of the educational environment is the active involvement of students in the learning process. This includes a variety of activities: game techniques, project tasks and research that contribute not only to the assimilation of knowledge, but also to the formation of critical thinking. In a developing educational environment, students become not just passive listeners, but active participants in the learning process. In addition, a developing educational environment should be supportive and inspiring. This means creating an atmosphere of trust where students feel comfortable experimenting and making mistakes. Interaction with teachers and peers also plays an important role, contributing to social and emotional development. Thus, the developing educational environment is a multifaceted system aimed at the comprehensive development of personality and successful socialization of children. Creating such an environment requires teachers to apply innovative methods and approaches aimed at involving all students, regardless of their level of training.
Moths (Lepidoptera: Heterocera) collected with light attractant in Serra de Itabaiana National Park, Sergipe, Brazil
Authors: Dantas José Oliveira , Pereira Arivania Santos , Souto Leandro Sousa , Marques Ana Paula Coelho
Published: December 2024

Lepidoptera includes the butterflies and moths, being considered the second largest order of Insecta, with about 16% of all of the known species in this class. Few lists of Lepidoptera exist for the Northeast of Brazil, a poorly inventoried geographical area. This work had as main objective to accomplish a preliminary study of the moths collected with attractive light at the Parque Nacional Serra de Itabaina, Sergipe, Brazil, verifying the taxonomic diversity and abundance in the study area and analyzing some ecological aspects of the group. A total of 1,450 samples was collected, of which 447 were identified in 19 families. The remaining of the material consisted of 794 microlepidopterous and another 209 not identified specimens. The richness and abundance of lepidopterous did not vary significantly among the dry and rainy seasons (p> 0.05). However, the composition analysis (NMDS) separated the species in two distinct assemblages, but the similarity analysis indicated that this arrangement does not differ significantly (ANOSIM; p = 0.09; R = 0.22), indicating that the nocturnal lepidopterofauna of Serra de Itabaiana stays constant along the year. The time which has a larger number of collected lepidopterous, was from 18:00 to 21:00h. This is a preliminary study, but that serves as reference for other studies with Lepidoptera in Sergipe.
Association between Rosacea and Risk Factors - A Literature Review
Authors: Furgalska-Kudła Julia , Suława Adrian , Targoński Oskar , Targońska Marta , Fedorowicz Sebastian , Basiak Aneta , Ptasiński Aleksander , Niekurzak Rafał , Buczek Agnieszka
Published: December 2024

Introduction and purpose: Rosacea is a common chronic inflammatory disease with four clinical subtypes based on the predominant signs and symptoms. The majority of patients present skin problems like reddening, papules or pustules, swelling of the face and nose, and eye symptoms like dryness, tearing, and redness. Anxiety and depression associated with rosacea deeply affect the quality of patients' lives. Yet, the pathogenesis of rosacea remains poorly understood, with suggestions of involvement from various complex factors like immune dysregulation, genetic factors, neurovascular dysregulation, micro-organisms, and environmental factors as promoting features of rosacea.
Aim of the study: The purpose of this article is to investigate the association between factors like alcohol intake, Helicobacter pylori infection, and cardiovascular diseases and the risk of developing rosacea.
Material and methods: An analysis of papers available in PubMed, Google Scholar, and Springer Link was performed. 
Conclusion: The knowledge presented in this review suggests the existence of links between rosacea and various risk factors like alcohol intake, infection of H.pylori, and Cardiovascular diseases. Considering the clinical and pathological differences among rosacea subtypes, it is essential to explore the role of alcohol in each subtype separately. While rosacea may not be directly associated with IHD, stroke, or diabetes, it does show correlations with hypertension and dyslipidemia. Rosacea is significantly associated with a higher prevalence of HP infection, but high-quality prospective studies are needed to ascertain if Helicobacter Pylori is a risk factor for rosacea. Further investigations are warranted to validate these findings and explore underlying mechanisms. The predisposing factors revealed in this study could help us gain insights into rosacea pathophysiology and develop interventions especially targeting modifiable risk factors.
The Role of Vitamin D in Acne Vulgaris: A Comprehensive Review of Recent Advances
Authors: Kwaśna Julia , Bychowski Mateusz , Górski Mateusz , Załęska Adrianna , Kaźmierczyk Izabela , Lenart Kacper , Homza Michał , Zakrzewska Natalia , Bednarek Szymon , Kulicka Joanna
Published: December 2024

Acne vulgaris is a common dermatological condition affecting millions worldwide, particularly adolescents and young adults. Recent research suggests a potential link between vitamin D levels and acne severity, highlighting the role of vitamin D in immune regulation and inflammation. This review analyzes studies published from 2020 onward, focusing on the relationship between vitamin D deficiency and acne, as well as the therapeutic potential of vitamin D supplementation.
A systematic search on PubMed identified 10 significant studies, including 7 original research articles and 3 systematic reviews or meta-analyses. The findings indicate a notable prevalence of vitamin D deficiency among acne patients, with several studies showing significantly lower serum 25-hydroxyvitamin D levels compared to healthy controls. Furthermore, clinical trials demonstrated that topical vitamin D can effectively reduce inflammatory markers, suggesting its therapeutic potential.
Despite these findings, the relationship between vitamin D levels and acne severity is complex, with some studies showing no significant correlation. This inconsistency underscores the need for further investigation into the mechanisms linking vitamin D deficiency to acne. Overall, this review emphasizes the potential of vitamin D as a therapeutic target in acne management and calls for more robust studies to clarify its role in mitigating acne-related inflammation and improving patient outcomes.
Lemierre's syndrome: a forgotten disease
Authors: Pilarz Anna , Sosin Julia , Salamon Dariusz , Stachowiak Julia , Zwierzchowska Maria , Sojka Aleksandra , Domagała Wojciech
Published: December 2024

Lemierre's syndrome or Lemierre's disease is septicemia in the course of angina. It is a rare disease that occurs during or after pharyngitis and appears as inflammation of the internal jugular vein and subsequent embolic abscesses in the lungs or viscera. It is most commonly seen in teenagers and young adults. Lemierre's syndrome has long been treated as a forgotten disease, but its incidence is now rising again.
Aim of the study:
Due to the high prevalence of benign oral and pharyngeal infections in adolescents, the diagnosis of Lemierre's syndrome is often difficult to catch initially. This can result in delays in treatment. This work describes the diverse presentation of Lemierre's syndrome, diagnostic options, and highlights the role of the interdisciplinary team in the care of these patients.
Materials and methods:
A systematic review of scientific and medical literature from the PubMed and Google Scholar databases was conducted.
Results:
Given the potential catastrophic consequences, including septicemia, multiple organ failure and death, it is imperative to quickly recognize Lemierre's syndrome based on the clinical picture, followed by targeted diagnostic testing and immediate initiation of broad-spectrum antibiotics. Increasing awareness of Lemierre's syndrome among physicians is key to facilitating rapid diagnosis and life-saving treatment.
Variasi Klorofil-a di Perairan Sekitar Laut Jawa, Laut Flores, dan Selat Makassar
Authors: Handoko Eko Yuli , Syariz Muhammad Aldila , Hanansyah Megivareza Putri
Published: December 2024

Laut Jawa, Flores, dan Selat Makassar merupakan daerah pertemuan massa air dan juga merupakan salah satu titik masuk Arus Lintas Indonesia. Massa air tawar dari Samudera Pasifik masuk ke perairan Indonesia melalui Selat Makassar. Tidak hanya itu, wilayah maritim Indonesia dipengaruhi oleh Muson Asia-Australia yang mempengaruhi produktivitas primer di perairan, ditunjukkan dengan variasi klorofil-a. Maka dari itu, perlunya pemahaman tentang dinamika klorofil-a untuk penentuan strategi pengelolaan ekosistem laut yang lebih baik. Tujuan dari penelitian ini adalah untuk menganalisis variasi klorofil-a di perairan sekitar Laut Jawa, Flores, dan Selat Makassar, serta hubungannya dengan suhu dan salinitas dari tahun 2016-2023. Penelitian ini menggunakan data klorofil-a yang dikumpulkan dari sensor Ocean and Land Color Instrument dari Sentinel-3. Data klorofil-a berasal dari perhitungan algoritma Ocean Color 4 for MERIS untuk jenis perairan case-1. Dari penelitian ini, didapatkan hasil bahwa konsentrasi klorofil-a cenderung tinggi saat periode muson barat bersamaan dengan datangnya musim hujan yang meningkatkan limpasan air sungai. Sebaliknya, konsentrasi klorofil-a di perairan Selatan Jawa hingga Nusa Tenggara cenderung tinggi saat muson timur diikuti dengan penurunan Suhu Permukaan Laut dan kenaikan salinitas permukaan. Pada tahun 2018 dan 2019, terjadinya fenomena El Niño bersamaan dengan fase positif Indian Ocean Dipole mendorong peningkatan klorofil-a. Rata-rata klorofil-a sepanjang tahun 2018 hingga 2019 mencapai 0,71  di Laut Flores dan Selat Makassar, serta 0,73  di Laut Jawa. Penelitian lebih lanjut dengan rentang temporal klorofil-a yang lebih panjang diperlukan agar pengaruh fenomena global dapat terlihat lebih jelas.
Analisis Perbandingan Polarisasi VV dan VH Citra SAR Sentinel-1 untuk Identifikasi Area Genangan Banjir di Kec. Masamba, Kab. Luwu Utara Dengan Metode Water-S1
Authors: Palgunadi Imam Rosyid Priska , Bioresita Filsa
Published: December 2024

Peristiwa banjir merupakan salah satu peristiwa yang sering terjadi di berbagai wilayah Indonesia, salah satunya Kecamatan Masamba, Kabupaten Luwu Utara. Pemanfaatan teknologi penginderaan jauh berupa citra satelit dapat digunakan dalam melakukan identifikasi genangan banjir sebagai upaya melakukan pemantauan kejadian banjir yang terjadi di suatu wilayah. Citra SAR merupakan salah satu citra yang dapat dimanfaatkan dikarenakan citra jenis ini dapat memperoleh data dalam kondisi cuaca apapun, dimana salah satunya adalah citra Sentinel-1. Pada penelitian ini akan dilakukan identifikasi genangan banjir menggunakan dua jenis polarisasi citra satelit Sentinel-1 yaitu VV (Vertikal-Vertikal) dan VH (Vertikal-Horizontal), dimana pada umumnya dalam identifikasi banjir hanya menggunakan salah satu diantara dua jenis polarisasi tersebut. Metode yang akan digunakan yaitu Water-S1 dimana metode ini merupakan metode identifikasi air permukaan secara otomatis. Untuk menguji akurasi hasil identifikasi banjir, dalam penelitian ini akan menggunakan peta dampak genangan banjir ICube SERTIT pada peristiwa banjir Masamba tahun 2020. Hasil akhir yang diperoleh pada penelitian ini adalah area yang teridentifikasi sebagai genangan banjir adalah 649,469 ha (VH) dan 336,567 ha (VV). Nilai akurasi keseluruhan identifikasi genangan banjir pada polarisasi VV sebesar 90 % dengan nilai koefisien kappa 0,8 dan pada polarisasi VH diperoleh sebesar 96% dan nilai koefisien kappa 0,92. Berdasarkan hasil tersebut diketahui bahwa citra SAR Sentinel-1 Polarisasi VH lebih baik untuk digunakan dalam mengidentifikasi area genangan banjir pada studi area.
Pemanfaatan Data Citra Satelit Sentinel-2 untuk Estimasi Kandungan Nitrogen Pada Tanaman Jagung (Studi Kasus : Desa Jadi, Kecamatan Semanding, Kabupaten Tuban)
Authors: Azmi Rahajeng Aulia , Jaelani Lalu Muhamad , Sumargana Lena
Published: December 2024

Jagung (Zea mays L.) adalah tanaman semusim dengan beberapa varietas, termasuk NK 6172 (Perkasa), NK 212 (Wirosableng), dan NK 7328 (Sumo). Identifikasi varietas jagung dilakukan menggunakan metode Linear Spectral Unmixing yang menghasilkan peta sebaran varietas, dimana NK 6172 (Perkasa) mendominasi dengan 80,97%, diikuti oleh NK 7328 (Sumo) dengan 15,15%, dan NK 212 (Wirosableng) dengan 3,48%. Untuk mengidentifikasi fase pertumbuhan jagung ditentukan menggunakan citra MODIS dan algoritma NDVI serta NDWI. Pada penelitian ini lahan jagung diklasifikasikan dengan metode Support Vector Machine dan menghasilkan nilai overall accuracy sebesar 89,29% dan nilai kappa sebesar 86,42%. Nitrogen (N) adalah salah satu nutrisi penting untuk pertumbuhan jagung. Salah satu metode untuk memperkirakan kandungan nitrogen dapat melalui penginderaan jauh yaitu dengan melakukan pengolahan spektrum cahaya yang dipantulkan oleh daun. Dilakukan dengan citra satelit Sentinel-2 serta menggunakan indeks vegetasi OSAVI, GNDVI, dan SRRE. Hasil penelitian menunjukkan bahwa ketiga indeks ini memiliki korelasi positif dengan kandungan nitrogen pada varietas NK 6172 (Perkasa). Lalu indeks SRRE memiliki koefisien determinasi tertinggi (0,3874), diikuti oleh OSAVI (0,3751) dan GNDVI (0,3537). Model estimasi kandungan nitrogen dibuat dari regresi linier antara data kandungan nitrogen berbasis SPAD dengan indeks SRRE. Lalu dihasilkan peta yang menunjukkan kandungan nitrogen, dimana kandungan nitrogen dominan pada lahan eksisting dengan rentang 2% - 2,5%.
Pipeline Modeling using UAV LiDAR Technology
Authors: Himawan Iwan Qodar , Fitri Listiyo , Widjajanti Nurrohmat , Azizi Iqbal Hanun
Published: December 2024

Pipelines play an important role in operations in energy supply companies, whether geothermal, gas, or petroleum. Pipeline damage, such as corrosion, dents, and leaks caused by natural or human factors, must be detected. Problems with pipeline assets will indirectly impact high production prices. Pipeline asset mapping must be carried out precisely, quickly, and quietly, considering that the existence of pipelines often causes social unrest. This research analyzed the capabilities of UAV LiDAR for mapping pipelines and support in a three km-long pipeline area. The study concluded that UAV LiDAR can map the position of the pipeline, its position to the ground, the position of the support, and the height of the support on a pipeline network with a diameter of 1 m. This capability applies not only to segments in open areas but also to those covered by vegetation. When orthophoto cannot display the pipeline's existence, the LiDAR point cloud can identify it. This main pipeline, which has a 1 m diameter, 3-D mesh, and 3-D models, can also be formed well. The accuracy of the resulting map is 11.5 cm at a confidence level of 90%. The length of time required from preparation to the presentation of the pipeline longitudinal profile map is eight calendar days with ten manpower.