bluuebunny/crossref_metadata_2025 huggingface dataset:
11β-HSD1 Modulates the Set Point of Brown Adipose Tissue Response to Glucocorticoids in Male Mice
Authors: Doig Craig L. , Fletcher Rachel S. , Morgan Stuart A. , McCabe Emma L. , Larner Dean P. , Tomlinson Jeremy W. , Stewart Paul M. , Philp Andrew , Lavery Gareth G.
Published: June 2017

Glucocorticoids (GCs) are potent regulators of energy metabolism. Chronic GC exposure suppresses brown adipose tissue (BAT) thermogenic capacity in mice, with evidence for a similar effect in humans. Intracellular GC levels are regulated by 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) activity, which can amplify circulating GC concentrations. Therefore, 11β-HSD1 could modulate the impact of GCs on BAT function. This study investigated how 11β-HSD1 regulates the molecular architecture of BAT in the context of GC excess and aging. Circulating GC excess was induced in 11β-HSD1 knockout (KO) and wild-type mice by supplementing drinking water with 100 μg/mL corticosterone, and the effects on molecular markers of BAT function and mitochondrial activity were assessed. Brown adipocyte primary cultures were used to examine cell autonomous consequences of 11β-HSD1 deficiency. Molecular markers of BAT function were also examined in aged 11β-HSD1 KO mice to model lifetime GC exposure. BAT 11β-HSD1 expression and activity were elevated in response to GC excess and with aging. 11β-HSD1 KO BAT resisted the suppression of uncoupling protein 1 (UCP1) and mitochondrial respiratory chain subunit proteins normally imposed by GC excess. Furthermore, brown adipocytes from 11β-HSD1 KO mice had elevated basal mitochondrial function and were able to resist GC-mediated repression of activity. BAT from aged 11β-HSD1 KO mice showed elevated UCP1 protein and mitochondrial content, and a favorable profile of BAT function. These data reveal a novel mechanism in which increased 11β-HSD1 expression, in the context of GC excess and aging, impairs the molecular and metabolic function of BAT.
Remembering the Elizabeth Bay Reclamation and the Holocene Sunset in Sydney Harbour
Authors: Byrne Denis
Published: June 2017

Projects of coastal reclamation have allowed humanity to expand its terrestrial foothold, often quite dramatically, although the act of extension may be forgotten as we come to naturalize these new lands as timeless terra firma. Against this possibility, my investigation of the 1880s reclamation of the Elizabeth Bay foreshore on Sydney Harbour, Australia, is a work of recall or recovery. The introduction by British colonists in the late 1700s of the notion of “capital in land” both underwrote the dispossession of the bay’s indigenous inhabitants and stimulated a thirst for land that led colonists and their descendants to want to push the shoreline out into the sea. As my inquiry deepens, other temporalities come into view alongside this colonial narrative. Formed around 300 million years ago in the Sydney area, the sandstone that was used to construct the seawall is found to be eroding in a manner that allows the sea to advance inland a millimeter at a time, back toward where it was prior to the reclamation. In doing so, the sandstone appears to be at least as amenable to the sea’s impetus as it is to the human intention for it to defend the reclamation against the sea. Meanwhile, earthworms active in the “artificial earth” of the reclamation undermine and bury objects such as lost coins and cigarette butts, causing them to subside into the earth at a rate of a few millimeters a year. Haunting the essay are the specters of rising and falling sea levels and my personal history with this reclamation in the year 1980. On bringing together these diverse temporal threads and processes, this article argues that archaeology has a particular role to play in bringing reclamations and other things of the Anthropocene into view.
Legalidade administrativa de carne e osso: uma reflexão diante do processo político brasileiro
Authors: Cyrino André
Published: June 2017

Para o entendimento convencional do direito administrativo brasileiro, o princípio da legalidade é repositório das mais elevadas expectativas democráticas e de contenção do poder. Nessa linha, é por meio da legalidade que será atendida a tão sonhada e revolucionária vontade geral, o que se desdobrou na defesa do direito administrativo da aplicação da lei de ofício. O objetivo deste artigo é discutir o equívoco dessa visão tradicional por meio das lentes da realidade política brasileira, conforme apresentada pela ciência política descritiva. Defendemos que o princípio da legalidade continua sendo elemento estruturante do direito administrativo, tal como determina o art. 37 da Constituição. Todavia, ele precisa ser apreendido de maneira realista, como uma legalidade de carne e osso, aqui entendida como mecanismo capaz de conter o arbítrio por meio da criação de custos de transação no processo político. For the conventional wisdom in Brazilian administrative law, the legality principle is a repository of the highest democratic expectations and restraint of power. According to this view, legality is the way to achieve the dream of a revolutionary general will, which was unfolded in the defense of an administrative law in which administrative action must be understood as something strictly and formally bounded to a legislative statute. The purpose of this article is to discuss the misconception of the traditional view through the lens of the Brazilian political reality as presented by positive political science. We argue that the principle of legality remains as a structuring element of administrative law, as stated in article 37 of the Constitution. Nevertheless, it must be perceived realistically, as a legality of flesh and blood, here understood as a mechanism capable of constrain arbitrariness through the creation of transaction costs in the political process.
Using spectral decomposition of the signals from laurdan-derived probes to evaluate the physical state of membranes in live cells
Authors: Mazeres Serge , Fereidouni Farzad , Joly Etienne
Published: June 2017

Background:We wanted to investigate the physical state of biological membranes in live cells under the most physiological conditions possible.

Methods:For this we have been using laurdan, C-laurdan or M-laurdan to label a variety of cells, and a biphoton microscope equipped with both a thermostatic chamber and a spectral analyser. We also used a flow cytometer to quantify the 450/530 nm ratio of fluorescence emissions by whole cells.

Results:We find that using all the information provided by spectral analysis to perform spectral decomposition dramatically improves the imaging resolution compared to using just two channels, as commonly used to calculate generalized polarisation (GP). Coupled to a new plugin called Fraction Mapper, developed to represent the fraction of light intensity in the first component in a stack of two images, we obtain very clear pictures of both the intra-cellular distribution of the probes, and the polarity of the cellular environments where the lipid probes are localised.

Our results lead us to conclude that, in live cells kept at 37°C, laurdan, and M-laurdan to a lesser extent, have a strong tendency to accumulate in the very apolar environment of intra-cytoplasmic lipid droplets, but label the plasma membrane (PM) of mammalian cells ineffectively. On the other hand, C-laurdan labels the PM very quickly and effectively, and does not detectably accumulate in lipid droplets.

Conclusions:From using these probes on a variety of mammalian cell lines, as well as on cells fromDrosophilaandDictyostelium discoideum, we conclude that, apart from the lipid droplets, which are very apolar, probes in intracellular membranes reveal a relatively polar and hydrated environment, suggesting a very marked dominance of liquid disordered states. PMs, on the other hand, are much more apolar, suggesting a strong dominance of liquid ordered state, which fits with their high sterol contents.
CALCULATION OF THE INTENSE DEFORMED CONDITION OF SOIL FOR TAMPER WITH CHANGEABLE GEOMETRY OF THE CASE
Authors: Моргунов Владимир , Morgunov Vladimir
Published: June 2017

The paper describes a new design for foundation compaction in vytrambovannyh pits, which allows to reduce material shell rammer on construction sites with a variety of engineering and geological conditions, as well as consider the problem of finding the parameters of the stress-strain state of subgrade compaction around this
Numerical research of horizontally weighted bases from hollow circular piles with the reduced step
Authors: Ямаева Светлана , Yamaeva Svetlana , Денисов Олег , Denisov Oleg
Published: June 2017

The results of numerical investigation of the stress-strain state of subgrade groups of hollow circular piles with diameters of less than three step under the action of horizontal loads. Shows the effect of pitch on piles move horizontally loaded the bases and a comparative analysis of the nature of their work with full-scale tests and numerical simulations. Pseudoplane used computational model of the foundation for the theory of local deformations and linearly deformable half.
Introduction to Philosophy
Authors: Платонова Светлана , Platonova Svetlana
Published: June 2017

The tutorial discusses the main parts of philosophy: theory of being and matter, theory of conscious and the unconscious, philosophy of knowledge, the problem of person and his being in the world, the nature and dynamics of society, global problems. The author presents philosophical questions, based on the history of philosophy and modern science. The essence of society is analyzed in accordance with the modern social-philosophical theories. The book combines the actual tutorial, issues, topics abstracts, bibliography to each chapter, philosophical dictionary.
The book is recommended for students of higher educational institutions, as well as all interested readers.
Technical monitoring of bridge constructions on a network of regional highways
Authors: Крахмальная Марина , Krakhmalnaya Marina , Евтушенко Сергей , Evtushenko Sergey , Крахмальный Тимофей , Krakhmalnyy Timofey
Published: June 2017

Authors reflected modern problems of technical condition of bridge constructions in a network of roads of regional appointment. In article the review and the analysis of the existing devices and systems of measurement of width of disclosure of cracks of bridge constructions is made, and also the description of the system of monitoring of a condition of cracks of bridge constructions developed by authors allowing to take in real time measurements and to automate process of data transmission by means of a wireless communication is provided.
Reconstruction of the stadium “Ermak” and Jubilee Square in the city of Novocherkassk
Authors: Кибалова Татьяна , Kibalova Tatyana , Тумасов Александр , Tumasov Aleksandr , Петренко Яна , Petrenko Yana
Published: June 2017

Reconstruction of the stadium “Ermak” in the city of Novocherkassk associated with the preparation for the World Cup in 2018. Analysis of existing buildings detects the variety (diversity) and disharmony in the artistic and compositional (art and composite) decision of the area. The structure of the objects forming the area included buildings of meliorative academy, cinema “Kosmos”, hotel “Novocherkassk” and a 14-storeyed house. The southern part of the square is finished now by the entrance group of premises of stadium which isn’t meeting the requirements of further development of the sporting object.

To complete the ensemble, its connection with the natural environment, selected the architectural and stylistic concept, expressed in the new object. The multifunctional (multipurpose) complex of the ‘Ermak’ stadium including premises of hotel, administration and trade can become such object. This object is a program in the preparation of all stadium for the forthcoming World Cup.
Optimization of Warehouse Processing Technology on the Basis of Economic Criteria
Authors: Пересветов  , Peresvetov Yu. , Вдовин  , Vdovin D. , Качалин  , Kachalin I.
Published: June 2017

Th e article considers the organization of the technology of warehouse cargo handling, the ABC (Activity based costing) method is researched, which is used to estimate the unit cost of technological operations, the analysis of existing

options for technological operations of processing the cargo fl ow of the warehouse with the allocation of cost objects is given.
Modern Energy Efficient Lighting Technologies
Authors: Байнева  , Bayneva I.
Published: June 2017

The article deals with modern energy efficient lighting technology. The relevance of energy issues in the modern world is considered. The areas of optimization and improvement of energy efficiency of lighting systems to the specification of the model events are identified. The tool of intensification of development of the market — energy efficient lighting technology with the use of led lamps-retrofit is described.
Relationship with Consumer: Approach of Quality Management
Authors: Баурина  , Baurina Svetlana
Published: June 2017

This article is devoted to research of features of customer relationship management from the standpoint of quality management. The main stages of the process of attracting and retaining consumers are identified. The article presents the basics of building a full relationship with consumers. Implementation of the requirements and recommendations of ISO 9000 series in terms of processes associated with the consumers is considered. The comparative characteristic of existing methods of customer relationship management is given.
Quality of Workplaces As One of the Basic Conditions for Effective Employment of the One-Industry Town Population
Authors: Одегов  , Odyegov YUriy , Павлова  , Pavlova V.
Published: June 2017

In the article the problem of development of one-industry towns is considered. As a result of the global financial crisis, which led to partial or absolute suspension of the core enterprises in 2008-2009, was disrupted the livelihoods of many company towns, in which the currently focused 24% of the urban population. Single-industry cities make up 14% of all cities in the country, which is home to about 35 million people [1]. To overcome the negative effects of the crisis on the life of single-industry towns of Russia is possible, according to the authors, the implementation of structural changes in the economy and in the provision of services to the population. This cannot be achieved without improving the employment structure of the population. In this regard the employment policy of single-industry towns should consider measures for the development of new forms of labor organization, small and medium business, creation of new jobs.
INFLUENCE OF NUTRITION BACKGROUND AND SURFACE IMPROVEMENT METHODS ON PRODUCTIVITY OF FLOODPLAIN MEADOWS OF MIDDLE VOLGA STEPPE REGION
Authors: Хисматуллин  , Khismatullin Marsel , Сафиоллин  , Safiollin Faik , Миннуллин  , Minnullin Gennadiy , Хисматуллин  , Khismatullin Mars
Published: June 2017

Low-cost technologies to improve floodplain meadows, based on maximum use of renewable factors, combined with a moderate inclusion in the manufacturing process non-renewable sources of anthropogenic energy are relevant. The purpose of the study – development of technology of surface improvement of flood meadows in combination with optimization of the backgrounds of mineral nutrition. Studies conducted in the last 5 years in the Republic of Tatarstan in the Central part of the floodplain of the river IK. Production test results of research carried out in 2015-2016 in the area of 60 hectares. The studies were carried out with guns (factor a): BD-4 (disc header), the Communist party and 5.4 (universal cultivator-cultivator with pin harrows, and spring rollers). As control was carried out direct reseeding of perennial grasses in single-disc sod seeder Sz-3,6. The field experiment was conducted on 4 backgrounds of mineral nutrition (Factor B): control (without fertilizers), the estimated dose NPK of 25, 30 and 35 t/ha of green mass. The developed technology of surface improvement of flood plains of, increase the productivity of floodplain meadows in 1.5-2.0 times, due to the improvement of water-physical soil properties, enhance biological processes, increasing density of the sward (in 1,3-1,4 times in comparison with direct sowing of grass seeds in sod without tillage), improvement of participation of alfalfa (from 8-16 to 26-28%) and improving levels of nutrition herbs. Consumption of phosphorus is increasing 1.4-1.5%, potassium 1.5-1.7 times and calcium is 2.1-2.3 times due to both mineralization of organic matter in the sod, and application of mineral fertilizers on the planned yield of green mass of 25-30 t/ha. However, because of the high cost of major nutrients (20-25 thousand RUB./t) variant on the planned yield of biomass improved flood meadows 35 t/ha return on investment is drastically reduced.
STATE REGULATION OF SOCIAL AND LABOR RELATIONS IN THE CONDITIONS OF SOCIALLY-ORIENTED ECONOMY
Authors: Мусаева  , Musaeva Gulshat , Файзрахманов  , Fayzrakhmanov Dzhaudat
Published: June 2017

The process of labor market regulation by the state involves a conscious and systematic actions, that minimize the negative aspects of the market mechanism. This is due to the fact that in Kazakhstan in the system of relations between employers and employees is always present state which, in turn, is also a major employer. In particular, a significant proportion of the working population is employed in the public sector, the state regulates conditions of employment and dismissal of workers in the private sector, in addition, between the state and the people there are relations concerning employment, training, transition, social security. An impact on reproduction and use of labor resources occurs through special institutions (ministries and departments), that are endowed functions of regulation and the right to control by the executive power, in addition, dispose of certain financial and material resources. The research of social and labor sphere in the foreground puts forward the study of the relations system, reflecting the social and economic interests of the people in the course of employment, namely the social and labor relations. Becoming of a socially oriented market economy in Kazakhstan and to ensure its normal functioning is possible provided its full integration into the world economy, which involves arrangements of social and labor relations in the country, development of a mechanism for effective regulation and embeddedness of the system of social and labor relations in the system, recognized by the international community.
RESULTS OF MULTIVARIATE EXPERIMENT TO DETERMINE DEPENDENCE OF THE MAXIMUM PRESSURE OF TRACTOR WHEELS ON THE SOIL FROM TRACTOR’S PARAMETERS AND PHYSICAL AND MECHANICAL PROPERTIES OF SOIL. ANALYSIS OF THE EQUATIONS
Authors: Хафизов  , Khafizov Kamil , Хафизов  , Khafizov Ramil
Published: June 2017

During statistical processing of proceeding of several variants of experiments the equation of maximum pressure of tractor wheels on the soil were obtained, depending on the tractor parameters and physical and mechanical properties of the soil. This paper analyzes the influence of the main factors on the maximum amount of wheels pressure on the ground. We revealed performance of equations beyond the experimental values of the factors. With an increase in the width of the wheel profile, its diameter, the speed of the tractor, the maximum pressure of wheel on the ground is reduced, and with increasing tractor’s weight on one wheel, the soil hardness, the pressure in wheel tire the maximum pressure of wheel on ground increases. Comparison with the data, available in the domestic and foreign journals, showed that the most stable prediction results of maximum pressure value of tractor wheels on the ground are obtained by using the first equation in the article. The prediction error of wheels maximum pressure values is in the range of 3 to 15%, depending on the brand of tractor and its working conditions.
Management of long-term conditions and dementia: The role of the Admiral Nurse
Authors: Knight Cathy , Dening Karen Harrison
Published: June 2017

As life expectancy increases so people often develop a range of conditions and disabilities in the years before death. Multimorbidity represents the most common ‘disease pattern’ found among the elderly and is characterised by complex interactions of co-existing diseases where a medical approach focused on a single disease does not suffice. People with dementia who also have other comorbidities do not always have their comorbid conditions managed as those without dementia which often lead to a high number of hospital admissions with longer lengths of stay and greater treatment costs. This case study presents the case management approach taken by Admiral Nursing in managing the complexities where there is comorbidity of a long-term condition and a diagnosis of dementia. By empowering the person and their carer with information and choices and through good case management and communication, people can be supported to live well and avoid inappropriate hospital admissions.
Análise do encaminhamento de atividades para a prática de análise linguística em livro didático do Ensino Fundamental
Authors: Bottega Rita Maria Decarli , Mattei Isabel
Published: June 2017

O livro didático distribuído gratuitamente aos alunos de escolas públicas do país constitui-se, em grande parte das vezes, como o principal material de apoio utilizado pelos professores da Educação Básica. Diante dessa realidade, a proposta deste artigo é analisar algumas atividades voltadas para o ensino de leitura, especificamente no que se refere à proposta da prática de análise linguística em gêneros textuais do livro do 9º ano do Ensino Fundamental intitulado Jornadas.port, das autoras Dileta Delmanto e Laiz B. de Carvalho (2012), buscando estabelecer relações com a concepção de linguagem apresentada no Manual do Professor. A análise das seções selecionadas – Recursos linguísticos; Reflexão sobre a língua; e Fique atento... – tiveram como foco, além do conteúdo apresentado no Manual do Professor, os contrastes entre o ensino normativo e o ensino reflexivo (análise linguística). Constatou-se, a partir das análises, que o livro em questão privilegia encaminhamentos e atividades condizentes com a proposta de análise linguística, na seção Recursos linguísticos, e com o ensino de regras gramaticais, nas seções Reflexão sobre a língua e Fique atento..., estabelecendo, portanto, na maior parte dos encaminhamentos, um direcionamento voltado para o ensino normativo.
Estudos das ausências nas artes da cena
Authors: Muniz Mariana Lima , Nunes Alexandre Silva , Berton Paulo Ricardo
Published: June 2017

Este artigo pretende discutir os binômios ausência/presença e real/virtual a partir da análise de espetáculos, dramaturgias e teorias acerca da interpretação teatral produzidos no final do século XX e início do século XXI. Na oposição ausência/presença, a característica lacunar do texto, da interpretação e da encenação, que se expandiu neste período histórico, ao lado de estéticas mais fechadas, passou a exigir a contribuição do espectador para a construção do sentido. Na oposição real/virtual, desde os conceitos clássicos da relação presença-ausência do ator-personagem até a difusão das tecnologias de transmissão remota de presença vem-se discutindo cada vez mais as condições de presença concretas e virtuais e o modo como agem sobre a cena.

ABSTRACT
The panel Absence Studies in the Performing Arts promotes a debate about the absence/presence and actual/virtual binaries through the analysis of XXIth Century plays and productions. In the first pair, the characteristic gaps found in drama and scene, very widespread in theatrical productions of the period, besides other more traditional styles, demanded the contribution of the spectator for the construction of meaning. The second opposition, with the spreading of the remote transmission technologies of presence brought the issue of the intromission of the virtuality onto the stage.
Keywords: absence/presence; actual/virtual; performing arts; XXIth century Theatre
Planetary Boundaries
Authors: Keppner Benno , Weiss Daniel , Kahlenborn Walter
Published: June 2017

Ein menschliches Wirken innerhalb der globalen Belastungsgrenzen ist ein Grundbaustein einer nachhaltigen Wirtschaftsweise. Der Ansatz der Planetary Boundaries gibt dazu den Rahmen vor. Doch vor welchen Herausforderungen stehen Unternehmen, die das Konzept umsetzen?
The determination of mimetic isomorphism levels on strategic plans of primary schools (Van province sample)
Authors: Arslan Mehmet , Altınışık Songül
Published: June 2017

Turkish public administration has been having a changing process both in public structure and legal infrastructure and this process called "restructured period". In parallel with this transformation in Turkish Public Administration, inspection activities have been also living the same process. In this term, institutions were asked to prepare their strategic plans according to the law, no 5018. The main problem of this study is to determinate the mimetic isomorphism levels according to new approach on strategic plans that prepared at primary schools. In this research, the strategic plans of the 32 primary schools in Van province were examined. Mimetic Isomorphism has been identified among these strategic plans.
Investigation of the relevance between democratic tendencies and classroom management perceptions of preservice physical education and classroom teachers
Authors: Inan Mehmet , Dervent Fatih
Published: June 2017

The main aim of this study is to determine the relevance between democracy tendencies and classroom management perceptions of preservice physical education and homeroom teachers who will teach in primary schools at 1-4 classes. The sample of the research was comprised of 4th grade students of Marmara University Atatürk Faculty Department of Primary Education and Department of Classroom Teaching (n=108) and School of Physical Education and Sport, Department of Teaching of Physical Education (n=30). In order to obtain the data Lutfu Ilgar's Classroom Management Skills Scale (r=0,809 and 0,790) and Democratic Tendency Scale which is composed by Akbaşlı, Yelken and Sünbül (r=0,74) were used. Correlation, t-test and variance analysis statistical techniques were used to analyze the collected data. Researh results show that there is a significantly positive correlation between democracy tendencies and classroom management perception of the preservice teachers (r=,414). Also it is determined that there is no significant difference between democracy tendencies and
Analysis of approaches to learning preferences and perceptions of learning of students in faculty of education
Authors: Ozan Ceyhun , Çiftçi Muhammed
Published: June 2017

Purpose of this study is to determine preference levels of approaches to learning and whether there is a significant difference as regards department, gender and class rank of preference levels of students in faculty of education. The research is a survey model. Universe of this research is comprised of students studying in Kazım Karabekir Education Faculty of Atatürk University in fall term 2011-2012 education year. Sample of the research is comprised of 393 candidate teachers that were selected randomly. Approaches and Study Skills Inventory for Students ' ASSIT has been employed to obtain research data. According to research results each of three approaches to learning is preferred with a percentage of over fifty nine out of a hundred. No significant difference was found between approach to learning preferences of candidate teachers in faculty of education according to field of the study, gender and class rank variables. Students stated to the term "learning" as to " Being able to use the information you've acquired".
Strategy, Performance Evaluation and Process Management in Higher Education Institutions
Authors: Da Silva Sabrina Letícia Couto , Vieira Letícia Canal , Da Silva Everson Pinto
Published: June 2017

The processes of Strategic Planning (SP), Performance Evaluation (PE) and Process Management (PM) for Higher Education Institutions (HEI) are considered more than ever, urgent and necessary, acting as the factors of motivation, awareness and exploratory data collection. The objective of this paper is to identify positive and negative aspects involved in realization of SP, PE and PM in HEI, through a literature review. The study was exploratory and descriptive, accomplished through a bibliographic review in online data bases. It was possible to identify that HEI are considered complex systems which results in implications on execution of the SP, PE and PM. Apart from that, it was identified barriers in the literature, being the main ones: decentralization, autonomy of departments, heterogeneity in the operation of departments, data stored in places that cannot be accessed by everybody, bureaucracy, resistance to change, dissociation between planning and management, lack of participation of university community in the process of planning. It was also found ways to overcome these barriers being the main ones: commitment of high management, clear strategy, wide communication and participation of all people involved.
The quasi experimental study of the influence of advertising creativity and exposure intensity toward buying action with aida approach
Authors: Budiawan Ramdan Dede , Satria Arif , Simanjuntak Megawati
Published: June 2017

Advertisement is one of marketing communication forms made by companies to reach sales goal of certain product. Advertising creativity is one of important factors that determines the success of television advertisement, beside that the exposure intensity also be determining factor to make the television advertisement get attention from spectators. To measure the spectators response toward advertisement in this research, the researcher used AIDA model. AIDA (attention, interest, desire, action) model is one of popular response hierarchy models for marketer as guidance to implement the marketing communication activities. The thesis analyzes the influence of advertising creativity and exposure intensity toward the buying action as the final stage of consumer in deciding the decision to buy product. The research used quasi experimental study to 80 respondents as the target market of the advertised, that is ice cream of Haan brand. The experiment as done in 2 treatments, treatment 1: one advertising exposure and treatment 2: three advertising exposures. The Mann Whitney difference test with SPSS program showed no significant differences between treatment of 1 exposure and 3 exposures. The SEM PLS analysis showed that advertising creativity influenced significantly to attention, interest, desire and action in buying product.
Mobile and cloud based systems proposal for a centralized management of educational institutions
Authors: Machado Leandro Medeiros de Almeida , Rita Felipe José Lopes , Santos Carlos Henrique da Silva
Published: June 2017

The computational technological efforts towards a centralized data storage and processing have contributed to provide more sustainable solutions under the environmental, administrative and business perspectives. However, it is not yet worldwide adopted by public institutions, specially, in the Brazilian educational systems, where these technological models are still under constant discussions and development. In this sense, this work presents a brief survey about cloud and mobile integrated technologies and their possible contributions to support a centralized data management in educational systems, relating improvements in governance, data security, mobility, economic viability and environmental impact. Therefore, this work also present a list of already free and private technologies and their advantages and disadvantages in the Brazilian scenario. In this sense, the herein technological aspects considers the integration between cloud and mobile technologies as essential alternative to suppress the online requirements, which a limitation for a large number of public institutions that have problems to be effectively connected on the Internet.
Digital manufacturing, industry 4.0, clould computing and thing internet: Brazilian contextualization and reality
Authors: Cardoso Wagner , Azzolini Junior Walther , Bertosse Jéssica Fernanda , Bassi Edson , Ponciano Emanuel Soares
Published: June 2017

The digital era represents significant changes in the design of IT projects with an emphasis on digital infrastructure, especially in terms of investment and professional qualification, which requires, in Brazil, the creation of specific lines of financing by government development agencies. The creation of demonstration platforms could be an effective initiative to stimulate the dissemination of the concept and the establishment of partnerships between customers and suppliers of new technologies. On the other hand, and particularly for the consumer market, corporations can create new business models and modify their relationships with their consumers, users and even competitors. In fact, today, "Thing Internet" has come to significantly modify the paradigms of perception, production and distribution of the capitalist world. This article discusses, covering and understanding the main reasons for the existence of this gap between theory and practice regarding digital manufacturing and adjacencies, the perspectives of technological innovations in the digital era specifically in Brazil. Its content is the result of a bibliographical review carried out from April to June 2016.
Functional Performance and Balance in the Oldest-Old
Authors: Kafri Michal , Hutzler Yeshayahu , Korsensky Olga , Laufer Yocheved
Published: June 2017

Background and Purpose:

The group of individuals 85 years and over (termed oldest-old) is the fastest-growing population in the Western world. Although daily functional abilities and balance capabilities are known to decrease as an individual grows older, little is known about the balance and functional characteristics of the oldest-old population. The aims of this study were to characterize balance control, functional abilities, and balance self-efficacy in the oldest-old, to test the correlations between these constructs, and to explore differences between fallers and nonfallers in this age group.

Methods:

Forty-five individuals living in an assisted living facility who ambulated independently participated in the study. The mean age was 90.3 (3.7) years. Function was tested using the Late-Life Function and Disability Instrument (LLFDI). Balance was tested with the mini-Balance Evaluation System Test (mini-BESTest) and the Timed Up and Go (TUG) test. Balance self-efficacy was tested with the Activities-Specific Balance Confidence (ABC) scale.

Results:

The mean total function LLFDI score was 63.2 (11.4). The mean mini-BESTest score was 69.8% (18.6%) and the mean TUG time was 12.6 (6.9) seconds. The mean ABC score was 80.2% (14.2%). Good correlation (r> 0.7) was observed between the ABC and the function component of the LLFDI, as well as with the lower extremity domains. Correlations between the mini-BESTest scores and the LLFDI were fair to moderate (r's range: 0.38-0.62). Age and ABC scores were significant independent explanators of LLFDI score (P= .0141 andP= .0009, respectively). Fallers and nonfallers differed significantly across all outcome measures scores, except for TUG and for the “Reactive Postural Control” and “Sensory Orientation” domains of the mini-BESTest.

Discussion and Conclusions:

The results of this study provide normative data regarding the balance and functional abilities of the oldest-old, and indicate a strong association between self-efficacy and function. These results emphasize the importance of incorporating strategies that maintain and improve balance self-efficacy in interventions aimed at enhancing the functional level of this cohort.
Effects of a 6-Week Upper Extremity Low-Volume, High-Intensity Interval Training Program on Oxygen Uptake, Peak Power Output, and Total Exercise Time
Authors: Pinto Nicole , Salassi James W. , Donlin Ayla , Schroeder Jan , Rozenek Ralph
Published: June 2017

Pinto, N, Salassi III, JW, Donlin, A, Schroeder, J, and Rozenek, R. Effects of a 6-week upper extremity low-volume, high-intensity interval training program on oxygen uptake, peak power output, and total exercise time. J Strength Cond Res 33(5): 1295–1304, 2019—The purpose of this study was to compare the effects of upper extremity (UE) high-intensity interval training (HIIT) to UE continuous training (CT) when training at a similar intensity. Twenty participants (mean age = 23 ± 3 years) were randomly assigned to either a HIIT (n = 10) or CT (n = 10) group. Participants completed a graded exercise test (GXT) utilizing arm cranking before and after 6 weeks (2 sessions per week) of UE training. During sessions, HIIT performed 10 repetitions of 60 seconds of work at 92.3 ± 1.0% of the arm HRpeak (%aHRpeak) and 60 seconds of passive recovery (%aHRpeak = 73.0 ± 4.0%) yielding an average training intensity of 82.6 ± 1.5 %aHRpeak. CT exercised for 20 minutes at an average intensity of 81.9 ± 2.2 %aHRpeak. After training, HIIT showed greater improvement in VO2peak compared with CT (Δ = 4.1 ml·min−1·kg−1, 95% confidence interval [CI]: 1.3–6.9 m·min−1·kg−1, p = 0.007). Total exercise time during the posttest GXT was also improved as a result of HIIT (Δ = 1.4 minutes, 95% CI: 0.4–2.3 minutes, p = 0.008). Both groups improved peak power output, but no difference was observed between them (Δ = 3.3 W, 95% CI: −3.3 to 9.9 W, p = 0.305). For a similar time investment, HIIT seemed to improve measures of cardiopulmonary capacity and exercise time to a greater extent than CT and may be a time-efficient alternative for those who incorporate UE aerobic activity into a training program.
Optical and chemical discoveries recognized for impact on biology and psychiatry
Authors: Deisseroth Karl
Published: June 2017

Karl Deisseroth was awarded the 2017 quadrennial 4 million euro Else Kröner Fresenius Prize today for the “discoveries of optogenetics and of hydrogel‐tissue chemistry, and for developing circuit‐level insight into depression”. In this opinion, he was invited to discuss the impact of optogenetics and hydrogel‐tissue chemistry on understanding the structure and function of the brain in health and disease.
CDK4 phosphorylation status and a linked gene expression profile predict sensitivity to palbociclib
Authors: Raspé Eric , Coulonval Katia , Pita Jaime M , Paternot Sabine , Rothé Françoise , Twyffels Laure , Brohée Sylvain , Craciun Ligia , Larsimont Denis , Kruys Véronique , Sandras Flavienne , Salmon Isabelle , Van Laere Steven , Piccart Martine , Ignatiadis Michail , Sotiriou Christos , Roger Pierre P
Published: June 2017

Cyclin D‐CDK4/6 are the first CDK complexes to be activated in the G1 phase in response to oncogenic pathways. The specific CDK4/6 inhibitor PD0332991 (palbociclib) was recently approved by the FDA and EMA for treatment of advanced ER‐positive breast tumors. Unfortunately, no reliable predictive tools are available for identifying potentially responsive or insensitive tumors. We had shown that the activating T172 phosphorylation of CDK4 is the central rate‐limiting event that initiates the cell cycle decision and signals the presence of active CDK4. Here, we report that the profile of post‐translational modification including T172 phosphorylation of CDK4 differs among breast tumors and associates with their subtypes and risk. A gene expression signature faithfully predicted CDK4 modification profiles in tumors and cell lines. Moreover, in breast cancer cell lines, the CDK4 T172 phosphorylation best correlated with sensitivity to PD0332991. This gene expression signature identifies tumors that are unlikely to respond to CDK4/6 inhibitors and could help to select a subset of patients with HER2‐positive and basal‐like tumors for clinical studies on this class of drugs.
Long-acting PEGylated recombinant human growth hormone (Jintrolong) for children with growth hormone deficiency: phase II and phase III multicenter, randomized studies
Authors: Luo Xiaoping , Hou Ling , Liang Li , Dong Guanping , Shen Shuixian , Zhao Zhuhui , Gong Chun Xiu , Li Yuchuan , Du Min-lian , Su Zhe , Du Hongwei , Yan Chaoying
Published: June 2017

Objective

We assessed the efficacy and safety of a weekly pegylated human growth hormone (PEG-rhGH) (Jintrolong) vs daily rhGH for children with growth hormone deficiency (GHD).

Design

Phase II and III, multicenter, open-label, randomized controlled trials.

Methods

108 and 343 children with treatment-naive GHD from 6 hospitals in China were enrolled in the phase II and III studies respectively. Patients in the phase II study were randomized 1:1:1 to weekly Jintrolong (0.1 mg/kg/week PEG-rhGH complex), weekly Jintrolong (0.2 mg/kg/week PEG-rhGH complex) or daily rhGH (0.25 mg/kg/week) for 25 weeks. Patients in the phase III study were randomized in a 2:1 ratio to weekly Jintrolong (0.2 mg/kg/week) or daily rhGH (0.25 mg/kg/week) for 25 weeks. The primary endpoint for both studies was height velocity (HV) increase at the end of treatment. Other growth-related parameters, safety and compliance were also monitored.

Results

The phase II study established the preliminary efficacy, safety and recommended dose of Jintrolong PEG-rhGH. In the phase III study, we demonstrated significantly greater HV increases in patients receiving Jintrolong treatment (from 2.26 ± 0.87 cm/year to 13.41 ± 3.72 cm/year) vs daily rhGH (from 2.25 ± 0.82 cm/year to 12.55 ± 2.99 cm/year) at the end of treatment (P < 0.05). Additionally, significantly greater improvement in the height standard deviation scores was associated with Jintrolong throughout the treatment (P < 0.05). Adverse event rates and treatment compliance were comparable between the two groups.

Conclusion

Jintrolong PEG-rhGH at a dose of 0.2 mg/kg/week for 25 weeks is effective and safe for GHD treatment and is non-inferior to daily rhGH.
Enhanced self-efficacy after a self-management programme in pituitary disease: a randomized controlled trial
Authors: Andela Cornelie D , Repping-Wuts Han , Stikkelbroeck Nike M M L , Pronk Mathilde C , Tiemensma Jitske , Hermus Ad R , Kaptein Adrian A , Pereira Alberto M , Kamminga Noelle G A , Biermasz Nienke R
Published: June 2017

Context

Patients with pituitary disease report impairments in Quality of Life (QoL) despite optimal biomedical care. Until now, the effects of a self-management intervention (SMI) addressing psychological and social issues for these patients and their partners have not been studied.

Objective

To examine the effects of a SMI i.e. Patient and Partner Education Programme for Pituitary disease (PPEP-Pituitary).

Design and subjects

A multicentre randomized controlled trial included 174 patients with pituitary disease, and 63 partners were allocated to either PPEP-Pituitary or a control group. PPEP-Pituitary included eight weekly sessions (90 min). Self-efficacy, bother and needs for support, illness perceptions, coping and QoL were assessed before the intervention (T0), directly after (T1) and after six months (T2). Mood was assessed before and after each session.

Results

Patients in PPEP-Pituitary reported improved mood after each session (except for session 1). In partners, mood only improved after the last three sessions. Patients reported higher self-efficacy at T1 (P = 0.016) which persisted up to T2 (P = 0.033), and less bother by mood problems directly after PPEP-Pituitary (P = 0.01), but more bother after six months (P = 0.001), although this increase was not different from baseline (P = 0.346). Partners in PPEP-Pituitary reported more vitality (P = 0.008) which persisted up to T2 (P = 0.034). At T2, partners also reported less anxiety and depressive symptoms (P ≤ 0.014).

Conclusion

This first study evaluating the effects of a SMI targeting psychosocial issues in patients with pituitary disease and their partners demonstrated promising positive results. Future research should focus on the refinement and implementation of this SMI into clinical practice.
Receiving Providers’ Perceptions on Information Transmission During Interfacility Transfers to General Pediatric Floors
Authors: Rosenthal Jennifer L. , Romano Patrick S. , Kokroko Jolene , Gu Wendi , Okumura Megumi J.
Published: June 2017

BACKGROUND:

Pediatric patients can present to a medical facility and subsequently be transferred to a different hospital for definitive care. Interfacility transfers require a provider handoff across facilities, posing risks that may affect patient outcomes.

OBJECTIVES:

The goal of this study was to describe the thoroughness of information transmission between providers during interfacility transfers, to describe perceived errors in care at the posttransfer facility, and to identify potential associations between thoroughness of information transmission and perceived errors in care.

METHODS:

We performed an exploratory prospective cohort study on communication practices and patient outcomes during interfacility transfers to general pediatric floors. Data were collected from provider surveys and chart review. Descriptive statistics were used to summarize survey responses. Logistic regression was used to analyze the association of communication deficits with odds of having a perceived error in care.

RESULTS:

A total of 633 patient transfers were reviewed; 218 transport command physician surveys and 217 frontline provider surveys were completed. Transport command physicians reported higher proportions of key elements being included in the verbal handoff compared with frontline providers. The written key element transmitted with the lowest frequency was a summary document (65.2%), and 13% of transfers had at least 1 perceived error in care. Transfers with many deficits were associated with higher odds of having a perceived error in care.

CONCLUSIONS:

Information transmission during pediatric transfers is perceived to be inconsistently complete. Deficits in the verbal and written information transmission are associated with odds of having a perceived error in care.
Neonatal Hypertension
Authors: Mistry Kirtida , Gupta Charu
Published: June 2017

In the past few decades, as neonatal intensive care technology has advanced, so has identification and awareness of hypertension in this population. As in older children, the definition of normal blood pressure and accordingly, hypertension, remains a statistical definition rather than based on outcomes. Although the overall incidence of hypertension in neonatal nurseries is low, certain groups of neonates are at higher risk and should be monitored more closely. This article reviews the parameters defining normal and elevated blood pressures in neonates using current available data, etiology and risk factors, approach to investigation, and management of neonatal hypertension.