bluuebunny/crossref_metadata_2025 huggingface dataset:
Plasmatic Soluble Receptor for Advanced Glycation End Products as a New Oxidative Stress Biomarker in Patients with Prosthetic-Joint-Associated Infections?
Authors: Massaccesi Luca , Bonomelli Barbara , Marazzi Monica Gioia , Drago Lorenzo , Romanelli Massimiliano Marco Corsi , Erba Daniela , Papini Nadia , Barassi Alessandra , Goi Giancarlo , Galliera Emanuela
Published: December 2017

Prosthetic joint infection (PJI) is the most common cause of failure of total joint arthroplasty, but a gold standard for PJI diagnosis is still lacking. Advanced glycation end products (AGEs) are proinflammatory molecules inducing intracellular oxidative stress (OS) after binding to their cell membrane receptors (RAGE). The aim of this study was to evaluate plasmatic soluble receptor for advanced glycation end products (sRAGE), as a new OS and infection marker correlating sRAGE to the level of OS and antioxidant defenses, in PJI, in order to explore the possible application of this new biomarker in the early diagnosis of PJI. Plasmatic sRAGE levels (by ELISA assay), plasma antioxidant total defenses (by lag time method), plasma reactive oxygen species (ROS), and thiobarbituric acid reactive substance (TBARS) levels (by colorimetric assay) were evaluated in 11 PJI patients and in 30 matched controls. ROS and TBARS were significantly higher (p<0.001) while plasma total antioxidant capacity and sRAGE were significantly lower (p<0.01) in patients with PJI compared to controls. Our results confirm the OS in PJI and show a strong negative correlation between the level of sRAGE and oxidative status, suggesting the plasmatic sRAGE as a potential marker for improving PJI early diagnosis.
Effects of Intentional Weight Loss on Markers of Oxidative Stress, DNA Repair and Telomere Length - a Systematic Review
Authors: Himbert Caroline , Thompson Henry , Ulrich Cornelia M.
Published: December 2017

Background: Altered levels of markers of oxidative stress, DNA repair, and telomere integrity have been detected in obese individuals and may underlie the pathogenesis of obesity-related diseases. However, whether or not such effects are reversed by intentional weight loss has not been systematically reviewed. Methods: A literature search in PubMed/Medline identified 2,388 articles of which 21 studies (randomized controlled trial (RCT) (n = 10) and non-randomized intervention studies (n = 11)) were classified as testing the effects of intentional weight loss on i) oxidative stress (n = 15), ii) DNA repair (n = 2), and iii) telomere length (n = 4). Results: Across a broad range of intervention designs, diet-, exercise-, surgery-, balloon-induced weight loss regimens decreased oxidative stress measures. Studies investigating DNA repair capacity or telomere length as endpoints after weight loss were less common in number and yielded null or inconsistent results, respectively. Conclusion: While this systematic review supports a role for intentional weight loss in reducing obesity-associated oxidative stress, it is not clear whether the effects are primary outcomes or secondary to improvement in obesity-associated insulin resistance and/or chronic inflammation. Although the lack of effect of intentional weight loss on DNA repair capacity might be anticipated given that oxidative stress is reduced, additional studies are needed. The inconsistent effects of weight loss on telomere length or DNA repair suggest the need for a re-assessment of intervention designs and assay methodology to definitively address this topic.
Association of Antibodies to Citrullinated Protein Antigens with Blood Pressure in First-Degree Relatives of Rheumatoid Arthritis Patients: The Studies of the Etiology of Rheumatoid Arthritis
Authors: Hughes-Austin Jan M. , Gan Ryan W. , Deane Kevin D. , Weisman Michael H. , Demoruelle M. Kristen , Sokolove Jeremy , Robinson William H. , Holers V. Michael , Norris Jill M. , Ix Joachim H.
Published: December 2017

Background: Hypertension is more common in patients with rheumatoid arthritis (RA) than in the general population. It is unknown whether hypertension is due to RA-related medications or the disease itself. Therefore, we sought to investigate associations between RA-related autoantibodies, specifically antibodies to citrullinated protein antigens (ACPA) and systolic blood pressure (SBP) and diastolic blood pressure (DBP) in first-degree relatives of RA patients, who were free of RA and RA-related medications. We hypothesized that a greater number of detectable ACPA would be associated with high SBP and DBP, independent of other risk factors in these first-degree relatives. Methods: We evaluated associations between ACPA and SBP and DBP in a cross-sectional study of 72 first-degree relatives (defined as parent, child, or sibling) of RA patients. Fifteen ACPA were measured using a Bio-Plex bead-based assay; each was dichotomized as positive/negative based on pre-specified cut-points. Analysis of covariance was used to evaluate associations between ACPA positivity and SBP and DBP, adjusting for age, sex, race, body mass index (BMI), pack-years of smoking, high sensitivity C-reactive protein (hsCRP), and current use of anti-hypertensive medications. Results: Average age was 51 and 69% were women. Mean SBP was 119 ± 18 and DBP was 74 ± 9 mm Hg. Thirty-three (46%) first-degree relatives were positive for ≥1 ACPA; and were younger, had lower BMI, more pack-years of smoking, and higher hsCRP concentrations compared to ACPA negative first-degree relatives. For each additional positive ACPA, SBP was 0.98 ± 0.5 mm Hg (p = 0.05) higher, and DBP was 0.66 ± 0.3 mm Hg (p = 0.04) higher. Anti-cit-fibrinogen A (211–230) positive and anti-cit-filaggrin positive first-degree relatives had 11.5 and 13.9 mm Hg higher SBP (p = 0.02) respectively. Anti-cit-clusterin, cit-filaggrin, and cit-vimentin positive first-degree relatives had 7–8 mm Hg higher DBP (p = 0.03, 0.05, 0.05 respectively), compared to being negative for these individual ACPA. Consistent with associations between ACPA, SBP, and DBP, anti-cyclic citrullinated peptides (anti-CCP2) positive first-degree relatives had 16.4± (p = 0.03) higher SBP and 12.1± mm Hg (p = 0.01) higher DBP than anti-CCP2 negative first-degree relatives. Conclusion: In first-degree relatives without RA, ACPA positivity is associated with higher SBP and DBP. Subclinical autoimmune processes and ACPA may play a role in the vascular changes potentially leading to hypertension prior to RA onset.
A produção artística de Tom Zé na década de 1970: considerações sobre o projeto da música “operária” e o disco Estudando o samba
Authors: Freire Guilherme Araujo
Published: December 2017

Este artigo trata da produção artística do compositor Tom Zé realizada durante o seu período de ostracismo e procura compreender melhor as especificidades de sua atuação e inserção no mercado musical brasileiro. Com base em discursos presentes em matérias publicadas em periódicos, pesquisamos o sentido da ação do compositor baiano ao desenvolver um projeto que designou como “música operária”: uma pesquisa experimental com ferramentas, máquinas de oficina e sons oriundos da execução de fitas magnéticas. Considerando que, na década de 1970, o gênero samba passava por uma fase de revitalização e ascensão de popularidade no mercado, realizamos um estudo sobre o disco Estudando o samba (1976), verificando de que maneira Tom Zé se posicionou artisticamente nos debates estét icos sobre o gênero.
A poesia erótica de Lucas José d’Alvarenga
Authors: Oliveira Gracinéa I.
Published: December 2017

O objetivo deste artigo é analisar a poesia erótica de Lucas José d’Alvarenga. Para execução desta análise, foi feita uma pesquisa monográfica, usando a técnica de pesquisa indireta, especificamente a bibliográfica, que consistiu em breve revisão da bibliografia já publicada referente ao livro de Lucas José d’Alvarenga, Poezias (1830), objeto desta pesquisa. A seleção e a análise dos poemas foram norteadas pelo conceito de erotismo, proposto por Octavio Paz. Foram identificados 13 poemas eróticos no livro, entre improvisos, quadras, sonetos e vilancetes. O erotismo foi representado nesses poemas através de antíteses e de metáforas, sendo as características eróticas mais recorrentes a imaginação, a percepção do sexo como recreação e a privacidade x o voyeurismo.
Philanthropy and Plutocracy
Authors: Fraser Andrea , Stone Eric Golo
Published: December 2017

Two texts by Andrea Fraser are reprinted as part of October's ongoing effort to publish contemporary documents of cultural activism that aims to create spaces of progressive resistance to threats of authoritarianism. Written as a speech delivered at the Museum Ludwig Cologne in 2017, Fraser's “Trusteeship in the Age of Trump,” demonstrates how the privatization of social services and the arts through philanthropy is part of a larger withdrawal of government responsibility for the welfare of its citizens. Accompanying the lecture is an open letter, drafted Andreas Fraser and Eric Golo Stone in late 2016 and signed by dozens of art world figures, demanding the resignation of now Treasury Secretary Steven T. Mnuchin from the Board of the Museum of Contemporary Art, Los Angeles.
Serendipity: Alchemy of Words: Abraham Abulafia, Dada, Lettrism Tel Aviv Museum of Art (16 June–19 November 2016)
Authors: Goldman-Ida Batsheva
Published: December 2017

“Museum Musings” relates to the exhibition Alchemy of Words: Abraham Abulafia, Dada Lettrism (Tel Aviv Museum of Art, 16 June–19 November 2016), discussing the connections made, discoveries, and considerations on what lay behind the unique constellation of the show.
Measurements of Directional Wave Spectra and Wind Stress from a Wave Glider Autonomous Surface Vehicle
Authors: Thomson Jim , Girton James B. , Jha Rajesh , Trapani Andrew
Published: December 2017

Methods for measuring waves and winds from a Wave Glider autonomous surface vehicle (ASV) are described and evaluated. The wave method utilizes the frequency spectra of orbital velocities measured by GPS, and the wind stress method utilizes the frequency spectra of turbulent wind fluctuations measured by an ultrasonic anemometer. Both methods evaluate contaminations from vehicle motion. The methods were evaluated with 68 days of data over a full range of open ocean conditions, in which wave heights varied from 1 to 8 m and wind speeds varied from 1 to 17 m s−1. Reference data were collected using additional sensors on board the vehicle. For the waves method, several additional datasets are included that use independently moored Datawell Waverider buoys as reference data. Bulk wave parameters are determined within 5% error with biases of less than 5%. Wind stress is determined within 4% error with 1% bias. Wave directional spectra also compare well, although the Wave Glider results have more spread at low frequencies.
Low-frequency electrical conductivity of aqueous kaolinite suspensions: surface conductance, electrokinetic potentials and counterion mobility
Authors: Weber Christian , Stanjek Helge
Published: December 2017

The low-frequency conductivity of aqueous kaolinite suspensions has been measured as a function of volume fraction and concentration of KCl, K2SO4and BaCl2, respectively. These measurements were interpreted with a theoretical model accounting for surface conductivity and particle shape. For the first time, an internally consistent data set was established by measuring all parameters necessary to solve the relevant equations. The simultaneous availability of surface conductivity, surface charge density and diffuse layer charge density permitted the estimation of counterion mobilities in the stagnant layer and a consistency check for the evaluation procedure of the conductivity experiments. In agreement with current literature results, monovalent counterions were found to have a Stern layer mobility similar to their bulk mobility, whereas the mobility of divalent counterions in this layer is reduced by a factor of ∼2.
Integrating Patient-Controlled Analgesia Using Implanted Intrathecal Pumps for Postoperative Pain Management: A Case Report
Authors: Peniche Alec , Poree Lawrence , Schumacher Mark , Yu Xiaobing
Published: December 2017

Intrathecal patient-controlled analgesia (IT-PCA) through implanted intrathecal infusion pumps has been increasingly utilized for severe cancer and chronic noncancer pain management. However, its application for acute postoperative pain management has not been reported to date. We present a case of a patient with an implanted intrathecal pump for chronic nonmalignant back pain who underwent an extensive spinal fusion surgery. The IT-PCA functionality of her intrathecal pump was successfully integrated into her postoperative multimodal pain regimen. Hence, IT-PCA can be safely incorporated into acute postoperative pain management with vigilant monitoring and close multidisciplinary collaboration.
Perfil epidemiológico e clínico de uma amostra populacional de pacientes com acromegalia no estado de Alagoas
Authors: Barboza Haiana Madeiro de Melo , Lopes Diandra Lourena de Oliveira , Ricardo Gustavo Piech , Suassuna de Albuquerque Camila , Mendonça Ferreira Thais de Alencar
Published: December 2017

Objetivo: determinar o perfil epidemiológico e clínico de pacientes com acromegalia no Estado de Alagoas. Métodos: trata-se de um estudo descritivo, observacional, que foi realizado na Farmácia de Medicamentos Excepcionais do Estado de Alagoas, abrangendo 12 pacientes com acromegalia dessa instituição, correspondendo a 85% dos acromegálicos do Estado de Alagoas. Resultados: dos 12 pacientes estudados, a média de idade foi de 50,8 +/- 12,1 anos e, no momento do diagnóstico, uma média de idade de 44,5 +/- 11,6 anos. Foram realizados exames de imagem em 91,6% dos pacientes, em que se evidenciou macroademona hipofisário no momento do diagnóstico. A octreotida foi o medicamento principal, utilizado em 92% dos pacientes. Conclusão: O estudo corrobora, em boa parte dos dados, a literatura atual e revela a necessidade de maior precocidade de diagnóstico e início de terapêutica adequada, evitando o surgimento de comorbidades e complicações típicas da doença.
Trinta anos de dengue no Ceará: história, contribuições para ciência e desafios no cenário atual com tripla circulação de arbovírus
Authors: De Góes Cavalcanti Luciano Pamplona , Almeida Barreto Francisca Kalline de , Alves Barbosa Oliveira Rhaquel de Morais , Pontes Canuto Ilana Frota , Bezerra Lima Antônio Afonso , Lima José Wellington Oliveira , Farias da Escóssia Kiliana Nogueira , Martins Victor Emanuel Pessoa , Alencar Carlos Henrique , Bezerra Perdigão Anne Caroline , Lima Daniele Malta , Cavalcante Ramalho Izabel Letícia , Carvalho Araújo Fernanda Montenegro de
Published: December 2017

Introdução: Embora os primeiros casos de dengue no estado do Ceará tenham ocorrido em 1986, há registros da presença do mosquito Aedes aegypti desde os anos de 1851/1852. Mesmo após 30 anos, a dengue permanece como um problema grave de saúde pública com epidemias cada vez mais frequentes. Objetivo: Resgatar, reunir e sintetizar a evidência científica produzida nos primeiros 30 anos de dengue no Ceará, contribuindo para melhorar sua compreensão e as intervenções de vigilância e controle. Métodos: Realizou-se uma revisão de literatura com busca de artigos (inglês, português e espanhol) nas bases de dados Pubmed, Scielo, Clinicalkey, Lilacs, Google Acadêmico e banco virtual de teses e dissertações da CAPES, além de livros. O período de 1986 a 2016 foi usado como limite de busca e a mesma foi realizada entre os meses de agosto a novembro de 2016. Utilizaram-se os descritores controlados: dengue, Ceará, Fortaleza e Aedes; com interposição do operador boleano “AND”. Resultados: Foram identificadas 574 publicações potencialmente elegíveis, sendo 461 artigos e 113 dissertações ou teses. Foram retirados 272 artigos duplicados ou que não atenderam aos critérios de inclusão. Foram lidos 114 artigos publicados em 60 revistas diferentes, sendo 72,8% artigos completos, 75,2% em inglês, 42,2% experimentais e 81,5% com abordagem quantitativa. Foi publicado apenas um artigo na década de 1980, já na década seguinte foram sete, número que cresceu bastante nos anos 2000, com 38 artigos. No entanto, já há 69 artigos publicados apenas na primeira metade da década de 2010. No período, o Ceará confirmou quase um milhão de casos de dengue, com a circulação dos quatro sorotipos (DENV1 - 1986, DENV2 - 1994, DENV3 - 2002 e DENV4 - 2011) e registrou pelo menos 14 epidemias. A partir de 2015, o Ceará passou a apresentar um cenário diferenciado de tripla epidemia, com a cocirculação autóctone de dois outros arbovírus: Chikungunya e Zika. Conclusão: Nesse período de 30 anos (1986-2016), o Ceará vivenciou várias epidemias de dengue, e, de certa forma, isto vem impulsionando a busca por respostas para o controle desta doença. Há claramente um crescimento em número de artigos publicados a cada ano, revelando a pujança dos grupos locais, que contribuiu de forma importante para a produção científica em diversos fatores relacionados à compreensão da epidemiologia e controle da dengue.
Qualidade de sono, qualidade de vida e rendimento escolar de crianças no litoral sul da Paraíba
Authors: Nascimento de Souza Lisânia Thais , Tomaz Renata Ramos
Published: December 2017

Introdução: O sono é um acontecimento fisiológico normal em todos os seres humanos. Quando há uma alteração durante esse processo, ocorrem também danos à saúde dos indivíduos, inclusive de crianças. Objetivo: Avaliar a qualidade de sono, a qualidade de vida e o rendimento escolar de crianças em um município no litoral sul da Paraíba. Método: A amostra do estudo foi constituída por 20 crianças saudáveis entre 5-10 anos, de ambos os sexos. Utilizou-se o questionário pediátrico sobre a qualidade de vida (PedsQL™ 4.0), a Escala de Distúrbios do Sono em Crianças (EDSC), e o rendimento escolar foi avaliado por meio das notas inseridas no Diário Escolar. A análise estatística foi por meio do software Statistical Package for the Social Science, versão 17.0. Foram usados o teste de Kolmogorov-Smirnov e o teste de correlação de Sperman. Resultados: Observou-se a prevalência da hiper-hidrose do sono (HS) em 15%, e o distúrbio respiratório do sono (DRS) em 10% das crianças. Foi identi-ficada uma moderada correlação positiva e significativa entre o rendimento escolar do primeiro e segundo bimestres (r= 0,6; p<0,01), entre dimensões emocionais e o rendimento escolar do primeiro bimestre (r= 0,4; p=0,03), ainda os DRS e o rendimento escolar do segundo bimestre (r= 0,4; p=0,03). Observou-se, ainda, uma moderada correlação negativa e significativa entre os distúrbios do despertar e as dimensões emocionais (r= -0,4; p=0,04). Conclusão: A má qualidade do sono foi capaz de causar danos à qualidade de vida e ao rendimento escolar das crianças avaliadas.
Φαγητό, άδειο στομάχι και χιουμοριστικές πτυχές της βρώσης στην παιδική λογοτεχνία. Η πείνα του Πινόκιο
Authors: Gavriilidis Sofia
Published: December 2017

Ο κλασικός ξύλινος ήρωας, ο Πινόκιο, είναι γνωστός για τη μύτη του που βλασταίνει και αυξομειώνεται ανεξέλεγκτα  και χωρίς την έγκρισή του κατόχου του - κάθε φορά που είτε ετοιμάζει μια σκανταλιά είτε λέει ψέματα. Παρά τις διάφορες ερμηνευτικές προσεγγίσεις και συμβολισμούς που μπορεί να προσλάβει μια ασύστολη μαρτυριάρα μύτη, αρκετά προκλητικό είναι και το θέμα της σχέσης του Πινόκιο με το φαγητό, ή μάλλον της έλλειψής του, και του διαρκούς αγώνα του για την αναζήτησή του. Θα μπορούσε ίσως το αριστούργημα του Κάρλο Κολόντι, Οι Περιπέτειες του Πινόκιο, να ερμηνευτεί βάσει της πείνας του Πινόκιο. Διότι ο Πινόκιο πεινάει, πεινάει συνέχεια, υποφέρει από αυτήν την «τρομερή αρρώστια που ονομάζεται πείνα».  «Κοντεύει να πεθάνει από την πείνα». Έχει μια πείνα που δεν λέει να ησυχάσει και είναι αυτή που τον ρίχνει σε κακοτυχίες και σε εφιαλτικές συναντήσεις με το σκληρό πρόσωπο της ζωής. Είναι μια πείνα που διαγράφεται με υπερβολές, που ξεφεύγει από τις ρεαλιστικές διαστάσεις της. Γίνεται κωμική και τραγική, όταν το ξύλινου αγόρι αναμετριέται μαζί της, μέσα από καρναβαλικά χιουμοριστικές ανατροπές και ματαιώσεις. Στις Περιπέτειες του Πινόκιο συνυπάρχουν γκροτέσκος ρεαλισμός και λεπτή ειρωνεία, εξ ορισμού αντιθετικές μορφές έκφρασης και τεχνικές πρόκλησης χιουμοριστικών γεγονότων. Αυτός ήταν και ο σημαντικότερος λόγος που προτείνεται μια εκ νέου ανάγνωσή του βιβλίου, εστιάζοντας στα ακραία γαστρονομικά και παράδοξα διατροφικά μυθοπλαστικά γεγονότα που συνδέουν μια πτυχή της ξύλινης υπόστασης του Πινόκιο με ένα κατεξοχήν ανθρώπινο ένστικτο: την πείνα.
EVOLUTION OF THE MICROSTRUCTURAL PARAMETERS OF COLD WORK Ti-6-Al-4V ALLOY
Authors: Mehdi Brahim , Kherrouba Nabil , Doufana Soumia , Badji Riad , Alili Baya
Published: December 2017

The aim of this work is to investigate cold worked Ti-6Al-4V (α+β) alloy. The alloy was examined by X-ray diffraction using Rietveld refinement method. MAUD software (Materials Analysis Using Diffraction) was used to analyze the microstructural parameters evolution (crystallite size, root mean square strain (r.m.s) and dislocation density. The Crystallite size is smaller in the β-phase compared to the α-phase. Microstrain and dislocation density are higher in the α-phase than those found in the β-phasefor the as received material. The microstructural parameters of Ti-6Al-4V alloy exhibit typical values of cold deformation state. The results show that the deformation process reducesthe crystallite size (coherent diffraction domains) from 520 to 210 Ȧ in the α-phase. Consequently, the r.m.s increases from 5 E-4 to 32 E-4 and the dislocation density increases from 2.92 E+10 to 4.6 E+11m-2after 85 % thickness reduction.
On-Farm Irrigation Reservoirs in Two Arkansas Critical Groundwater Regions: A Comparative Inventory
Authors: Yaeger Mary A , Reba Michele L , Massey Joseph H , Adviento-Borbe M Arlene A
Published: December 2017

Abstract. Arkansas, which ranks third in the nation in terms of irrigated cropland, relies heavily on the Mississippi River Valley alluvial aquifer for irrigation. Two critical groundwater areas have been identified, with one in the Grand Prairie in central Arkansas and the other along the Cache River in northeast Arkansas. Thus, there has been a call to develop surface water resources for irrigation, and as a result, on-farm irrigation reservoirs have been constructed to capture and store surface water. To assess the current state of surface water development, a remote-sensing survey using National Agricultural Imagery Program data was conducted to provide an inventory of the locations and surface area of on-farm reservoirs in the two critical groundwater areas. Expert consultation and on-site inspections were used to confirm the remote sensing results. In the larger Grand Prairie area, where aquifer decline was recognized earlier, 632 reservoirs were identified for a total surface area of 9,300 ha. In the Cache River area, 143 reservoirs were identified for a total surface area of 2,000 ha. Average reservoir size in both regions was 14.6 ± 20 ha and ranged from 1 to 265 ha. Reservoir area comprised approximately 3% and 1% of the areas of potentially-irrigated cropland in Grand Prairie and Cache River regions, respectively. Keywords: Aquifer depletion, Irrigation, On-farm reservoirs, Surface water.
A Study on the Effects of Harvester Off-Track Errors on Sugarcane Stubble Losses
Authors: Ma Shaochun , Karkee Manoj , Scharf Patrick A. , Zhang Qin , Tong, Junhua , Yu Long
Published: December 2017

Abstract.

The amount ofsugarcane stubble left in field is a major contributor to the total sugarcane loss in mechanical harvesting. Thus, reducing stubble height is an effective way to improve sugarcane recovery. The purpose of this study was to investigate how harvester off-track errors affect sugarcane stubble height and stubble loss. In this study, stubbles were sampled after harvesting, off-track errors and stubble weight were measured, and regression methods were used to model their relationships. Results showed an average stubble height as low as 0.16 m could be achieved if the harvester could track the crop row accurately. Based on the analysis of 33 randomly selected cane stools in the field, as the off-track error (the offset of actual harvester position from ideal position) increased from 0 to 1.46 m, the average stubble height increased from 0.13 to 1.41 m, which resulted in the average amount of stubble left in the field increasing from 0.07 to 0.80 kg. The results showed a strong positive correlation between stubble height (R2=0.91) or stubble weight (R2=0.89) and off-track errors. There were whole canes being completely left in the field either being missed or pushed down by the harvester when the off-track error was more than 0.76 m. Results suggest that improving the tracking accuracy during mechanical harvesting could substantially reduce stubble loss, leading to higher feedstock harvesting efficiency when using the existing sugarcane harvester. Keywords: Actual stubble height, Feedstock harvesting efficiency, Off-track error, Stubble loss, Sugarcane harvesting.
Prediction of basal glycaemia dynamics during treatment with 6-month lipid-lowering therapy in patients at high risk of cardiovascular disease
Authors: Koshelskaya Olga A. , Sushkova Anastasiya S. , Zhuravleva Olga A. , Vinnizkaya Irina V. , Brazovskaya Nataliya G. , Kravchenko Elena S. , Suslova Tatyana E. , Karpov Rostislav S.
Published: December 2017

Background. A major meta-analysis has confirmed the ability of statins to exert both diabetogenic and hyperglycaemic effects. To date, practical recommendations for predicting glucose dynamics during lipid-lowering therapy have not been developed.
Aims. Identify the combination of factors that can predict changes in basal glycaemia during 6-month lipid-lowering therapy in patients at high risk of cardiovascular disease.
Methods. This study reports on 50 patients with diabetes or impaired glucose tolerance, and 18 patients with coronary artery disease without disorders of carbohydrate metabolism. Of note, 29 of the 50 diabetic or glucose intolerant patients had documented ischaemic heart disease (stable angina). Patients were randomised into three groups: Gr.1 (n=33, atorvastatin therapy), Gr.2 (n=17, atorvastatin in combination with ezetimibe) and Gr.3 (n=18, rosuvastatin therapy). After treatment for 24 weeks, we assessed lipid profile dynamics, metabolism of glucose/insulin and the HOMA-IR index. Multivariate analysis was then performed to identify factors that predicted increases in basal glycaemia.
Results. All of the included patients completed 24 weeks of treatment (N=68). Lipid-lowering effect was significant in all three groups, and overall, target LDL cholesterol level was achieved in 50% of patients (n=34). In Gr.2, basal glucose level increased from 5.5(5.36.6) to 6.3(5.67.8) mmol/l (p=0.0014), which was accompanied by an increase in HOMA-IR (p=0.024). No significant change in basal glycaemia was observed in Grs.1 and 3. Moreover, an increase in the basal glycaemia was observed in 48.5% of patients in Gr.1, 70.6% in Gr.2 and 44.4% in Gr.3. Multivariate discriminant analysis across all patient groups revealed a canonical linear discriminant function that included the following factors: baseline basal glucose levels, total cholesterol levels, triglycerides and ratio of LDL/HDL cholesterol. Sensitivity and specificity of the model accounted for 75%; 51 out of the 68 cases were correctly classified when predicting the dynamics of basal glucose during lipid-lowering therapy.
Conclusions. Our data demonstrate the ability to predict the dynamics of the basal glycaemia during lipid-lowering therapy. This may allow for a new way to identify patients at high risk of statin-related increases in glycaemia.
Genetic parameters of wound healing in patients with neuropatic diabetic foot ulcers
Authors: Zaitseva Ekaterina L. , Tokmakova Alla Y. , Voronkova Iya A. , Petrov Vasily M. , Tiulpakov Anatoly N. , Shestakova Marina V.
Published: December 2017

Background. Tissue repair processes are impaired in diabetic foot ulcers (DFUs). Previous research has shown that glycaemic control, cytokines and growth factors play an important role in wound healing. Emerging evidence also suggests that genes play a role via their regulation of cell proliferation, collagen synthesis and granulation tissue formation.
Aim. To evaluate collagen genes expression in different stages of wound healing in patients with DFUs.
Materials and methods. Prospective study included four patients with neuropathic DFUs after surgical debridement. Tissue samples were taken for morphological and genetic tests on days 0, 10 and 15 of local treatment to evaluate expression of collagen genes (i.e. COL1A1, COL1A2, COL3A1) and to perform morphological tests.
Results. The present study confirmed that the size of wounds decreased by 8.8 7% after 10 days of local treatment and by 18.3 8% after 15 days of local treatment. According to histological examination of wound biopsies at day 10, all patients showed a tendency for lower levels of inflammatory infiltrate, increased number of fibroblast-like cells, presence of maturing granulation tissue and emergence of connective tissue fibres. After 15 days, we detected inflammatory infiltration in the wounds, despite the formation of mature granulation tissue. According to results of genetic analysis on day 10 of local wound treatment, we found a tendency for increased expression of collagen genes relative to the baseline: COL1A1 increased by 3.2 1.3 times, COL1A2 by 2.0 1.0 times and COL3A1 by 1.25 1.1 times. On day 15 of local treatment, in contrast, we found a tendency for decreased expression of COL1A1, COL1A2 and COL3A1 relative to the baseline (1.7 0.6, 2.5 2 and 20.0 3 times, respectively).
Conclusions. The expression of collagen genes (COL1A1, COL1A2, COL3A1) is more pronounced in proliferation phase and is subsequently reduced towards the end. These data were confirmed by morphological study and clinical pictures.
Prevalence of anemia in patients with type 1 and type 2 diabetes mellitus with chronic renal disease
Authors: Martynov Sergey A. , Shestakova Marina V. , Shilov Evgeniy M. , Shamkhalova Minara Sh. , Vikulova Olga K. , Sukhareva Olga Yu. , Trubitsyna Natalya P. , Egorova Darya N. , Bondarenko Olga N. , Dedov Ivan I.
Published: December 2017

Background. Diabetes mellitus (DM) is a non-infectious disease with a high prevalence worldwide and is one of the most common causes of diabetic kidney disease (DKD). Anaemia is a well-known complication of chronic kidney disease (CKD) and has been estimated to affect one in three adults with DM.
Aims. To evaluate the prevalence and severity of anaemia among patients with DKD and to compare the distribution of anaemia among patients with diabetic and non-diabetic CKD.
Methods. A total of 2,015 patients with DM [n = 807 with type 1 DM (T1DM); n = 1,208 with type 2 DM (T2DM)] and 244 patients with biopsy-proven chronic glomerulonephritis (CGN) were selected. Patients with glomerular filtration rate (GFR) of 15 ml/min/1,73 m2 (stage 5 CKD) and treated by erythropoietin-stimulating agents and/or iron medication were not included. The presence of anaemia was defined as haemoglobin (Hb) of 130 g/l in men and 120 g/l in woman. GFR was calculated using the MDRD formula. CKD stages were defined based on stages 14 of CKD by KDOQI and KDIGO guidelines: stage 1 (GFR 90 ml/min/1.73 m2); stage 2 (GFR 6089 ml/min/1.73 m2); stage 3 (GFR 3059 ml/min/1.73 m2); stage 3a (4559 ml/min/1.73 m2); stage 3b (GFR 3044 ml/min/1.73 m2); stage 4 (GFR 1529 ml/min/1.73 m2).
Results. Rates of anaemia were higher among patients with DM and DKD (38.8% and 22.6% for T1DM and T2DM, respectively) than diabetic patients without DKD (16.6% and 11.5%, respectively. Prevalence of anaemia by CKD stage increased from 23.3% in stage 1 to 80% in stage 4 among patients with T1DM, and from 16.9% to 81 % among patients with T2DM. The prevalence of anaemia was also higher among protoeinuric patients (53.9% and 34.4% for T1DM and T2DM, respectively) relative to microalbuminuric patients (29.4% and 17.6%, respectively). Anaemia prevalence was significantly greater in DKD due to T1DM (53.9%) than in CGN (19.7), and the rates did not differ based on stages of CKD.
Conclusions. We found a two-fold higher rate of anaemia among patients with DM and CKD than patients with DM and non-DKD. In addition, we found that the frequency of anaemia depends on renal function (i.e., stage of CKD) and degree of albuminuria. Taken together, anaemia is highly prevalent among patients with T1DM and DKD compared with patients with chronic CGN, without differences in its severity.
Physical restraint practice in psychiatric settings and psychiatric nursing approach
Psikiyatri kliniklerinde fiziksel tespit uygulaması ve psikiyatri hemşireliği yaklaşımı
Authors: Göktaş Ahmet , Buldukoğlu Kadriye
Published: December 2017

In psychiatric settings, physical restraint is used to control patients who are behaving in a way that harms themselves and their environment. Physical restraint negatively affects the patient physically, psychologically and socially. For these reasons, alternative methods can be used instead of physical restraint should be used before physical restraint used. The use of alternative methods also plays an important role in reducing the number of physical restraints. In the use of physical restraint, the characteristics of the patients in the setting should be considered and physical restraint should not be used in contraindicated situations. A physical restraint practice guide should be prepared by the health institutions taking into account the ethical and legal dimension of physical restraint. In this guide, the conditions that the nurse should pay attention to must be clearly stated together with the reasons. Such guidance is important in terms of protecting the health care institution, the nurse and the patient from legal problems. Intensive nursing care should be applied to the restrained patient. In particular, frequent checks should be made and regular records kept.The aim of this review is to give general information about physical restraint, to examine the legal and ethical dimension, to provide a physical restraint practice guide and to give information about the psychiatric nursing approach to the restrained patient.Extended English abstract is in the end of Full Text PDF (TURKISH) file. ÖzetPsikiyatri kliniklerinde kendisine ve çevresine zarar verme davranışında bulunan hastaları kontrol etmek için fiziksel tespit kullanılır. Fiziksel tespit hastayı fiziksel, psikolojik ve sosyal yönden olumsuz etkilemektedir. Bu nedenle fiziksel tespit uygulanmadan önce fiziksel tespit yerine kullanılabilecek alternatif yöntemler kullanılmalıdır. Alternatif yöntemlerin kullanılması fiziksel tespit sayısının azaltılmasında da önemli rol oynamaktadır. Fiziksel tespit kullanımında klinikteki hastaların özellikleri dikkate alınmalı ve kontrendike durumlarda fiziksel tespit uygulanmamalıdır. Sağlık kurumları tarafından fiziksel tespitin etik ve yasal boyutu dikkate alınarak, fiziksel tespit uygulama rehberi hazırlanmalıdır. Bu rehberde uygulamada dikkat edilmesi gereken durumlar, gerekçeleri ile birlikte belirtilmelidir. Böyle bir rehber sağlık kurumunu, hemşireyi ve hastayı yasal problemlere karşı korumak açısından önemlidir. Tespit edilen hasta için yoğun hemşirelik bakımı uygulanmalı, sık sık kontrol edilmeli ve sürece ilişkin düzenli kayıt tutulmalıdır.Bu derlemenin amacı, fiziksel tespite ilişkin genel bilgi vermek, yasal ve etik boyutunu incelemek, kullanılabilecek örnek bir fiziksel tespit uygulama rehberi sunmak ve tespit altındaki hastaya psikiyatri hemşireliği yaklaşımı hakkında bilgi vermektir.
Comparative analysis of coaxial magnetocumulative generators
Authors: Wołoszyn Mirosław , Jakubiuk Kazimierz , Zimny Pawel , Kowalak Daniel
Published: December 2017

This paper presents the results of a computer simulation of coaxial magnetocumulative current generators (MCGs). The simulation tests were carried out for different values of the internal diameter, length and speed of the deformation of the MGP element.
A photovoltaic source I/U model suitable for hardware in the loop application
Authors: Stala Robert , Penczek Adam , Mondzik Andrzej , Stawiarski Łukasz
Published: December 2017

This paper presents a novel, low-complexity method of simulating PV source characteristics suitable for real-time modeling and hardware implementation. The application of the suitable model of the PV source as well as the model of all the PV system components in a real-time hardware gives a safe, fast and low cost method of testing PV systems. The paper demonstrates the concept of the PV array model and the hardware implementation in FPGAs of the system which combines two PV arrays. The obtained results confirm that the proposed model is of low complexity and can be suitable for hardware in the loop (HIL) tests of the complex PV system control, with various arrays operating under different conditions.
Torque characteristics of double-stator permanent magnet synchronous machines
Authors: Awah Chukwuemeka Chijioke , Okoro Ogbonnaya Inya
Published: December 2017

The torque profile of a double-stator permanent magnet (PM) synchronous machine of 90 mm stator diameter having different rotor pole numbers as well as dual excitation is investigated in this paper. The analysis includes a comparative study of the machine’s torque and power-speed curves, static torque and inductance characteristics, losses and unbalanced magnetic force. The most promising flux-weakening potential is revealed in 13- and 7-rotor pole machines. Moreover, the machines having different rotor/stator (Nr/Ns) pole combinations of the form Nr = Ns ± 1 have balanced and symmetric static torque waveforms variation with the rotor position in contrast to the machines having Nr = Ns ± 2. Further, the inductance results of the analyzed machines reveal that the machines with odd rotor pole numbers have better fault-tolerant capability than their even rotor pole equivalents. A prototype of the developed double-stator machine having a 13-pole rotor is manufactured and tested for verification.
On autocommutators and the autocommutator subgroup in infinite abelian groups
Authors: Kappe Luise-Charlotte , Longobardi Patrizia , Maj Mercede
Published: December 2017

It is well known that the set of commutators in a group usually does not form a subgroup. A similar phenomenon occurs for the set of autocommutators. There exists a group of order 64 and nilpotency class 2, where the set of autocommutators does not form a subgroup, and this group is of minimal order with this property. However, for finite abelian groups, the set of autocommutators is always a subgroup. We will show in this paper that this is no longer true for infinite abelian groups. We characterize finitely generated infinite abelian groups in which the set of autocommutators does not form a subgroup and show that in an infinite abelian torsion group the set of commutators is a subgroup. Lastly, we investigate torsion-free abelian groups with finite automorphism group and we study whether the set of autocommutators
forms a subgroup in those groups.
Characterization of the essential oil from cone-berries of Juniperus communis L. (Cupressaceae)
Authors: Majewska Ewa , Kozłowska Mariola , Kowalska Dorota , Gruczyńska Eliza
Published: December 2017

Juniperus communis L. (Cupressaceae) is a plant widely cultivated in the Northern hemisphere. Juniper berries, the fruit of Juniperus communis L. are a highly valued, essential oil-rich plant material used traditionally in folk medicine as antiseptic, diuretic, antirheumatic, anti-inflammatory, antibacterial and antifungicidal agent. This paper reviews information on extraction methods of the essential oil from the juniper berries, its chemical composition and antimicrobial as well as antioxidant properties.
On Thermal Instability of Kuvshiniski Fluid with Suspended Particles Saturated in a Porous Medium in the Presence of a Magnetic Field June 13, 2017
Authors: Singh M.
Published: December 2017

The thermal instability of a Kuvshiniski viscoelastic fluid is considered to include the effects of a uniform horizontal magnetic field, suspended particles saturated in a porous medium. The analysis is carried out within the framework of the linear stability theory and normal mode technique. For the case of stationary convection, the Kuvshiniski viscoelastic fluid behaves like a Newtonian fluid and the magnetic field has a stabilizing effect, whereas medium permeability and suspended particles are found to have a destabilizing effect on the system, oscillatory modes are introduced in the system, in the absence of these the principle of exchange of stabilities is valid. Graphs in each case have been plotted by giving numerical values to the parameters, depicting the stability characteristics. Sufficient conditions for the avoidance of overstability are also obtained.
The legal discourse in respect of the status of deserted Jewish wives-Agunot in light of Halachic-Jewish Law Responsa of Rabbi Yaakov Moshe Toledano
Authors: Ovadia Moshe
Published: December 2017

This article addresses The legal discourse in respect of the status of deserted Jewish Wives-Agunot in light of Halachic-Jewish Law Responsa of Rabbi Yaakov Moshe Toledano [Jewish legal] work Hayam Hagadol (Cairo, 1931) and Bat Ami (Tel Aviv 1947), which belongs to the category of Rabbinic Responsa. From these sources we learn of the legal discourse and his halachic approach in matters related to legal status of deserted Jewish wives (“Agunot”). From his responsa we learn of his use of the legal discourse, how he combined fully spelled out words and acronyms in Hebrew, the main language of his writings. He also used Aramaic, and foreign words written in Hebrew letters, as well as technical terms. We learn of his approach after he had meticulously studied halachic problems and issues, and combined halacha with historical events that impacted on the Jews over the centuries. Using these he issued halachic rulings. He used common sense, and did not rule out modern inputs, but rather addressed them and reached a halachic decision in order to provide his petitioners an adequate response. This article examines whether he was a strict rabbinic adjudicator or tended towards leniency.
Effect of Propolis Oral Intake on Physiological Condition of Young Worker Honey Bees, Apis Mellifera L.
Authors: Damiani Natalia , Porrini Martín P. , Lancia Juan P. , Álvarez Estefanía , Garrido Paula M. , Domínguez Enzo , Gende Liesel B. , Eguaras Martín J.
Published: December 2017

Honey bees collect resin from various plant species and transform it into propolis that is incorporated into the nest. The role of resins in the bee health field is poorly understood. The aim was to evaluate the effects of forced consumption of propolis on the physiological condition and short-term survival of Apis mellifera worker bees. It was tested if the number of circulating hemocytes in hemolymph, the abdominal fat bodies and the hypopharyngeal glands development were affected by the feeding with propolis extracts in laboratory conditions during the warm and the cold seasons. Propolis added to sugar candy was consumed by workers for fourteen days without affecting the bee survival. The number of circulating hemocytes in hemolymph remained constant despite the differential diet during the experiment. However, the development of fat bodies and hypopharyngeal glands was altered by propolis ingestion. The abdominal fat body development in winter bees diminished after fourteen days of propolis consumption, while it increased in summer bees. The hypopharyngeal gland development decreased for the assayed period in workers from both seasons. Our results encourage us to continue exploring this research field and learn how long-term forced ingestion of a plant-derived compound, a non-nutritive substance, can modify physiological bee parameters. A broader understanding of the multiple roles of propolis in the health of the honey bee colonies could be obtained by studying the ways in which it is processed and metabolized and the effect that generates in another physiological responses.
T- and B-cell response analysis following calf immunisation with experimental Mycoplasma bovis vaccine containing saponin and lysozyme dimer
Authors: Dudek Katarzyna , Bednarek Dariusz
Published: December 2017

Introduction:
Mycoplasma bovis is a well-known cause of various disorders in cattle, such as pneumonia, arthritis, mastitis kerato-conjunctivitis, pharyngitis, laryngitis, otitis media, meningitis, and reproductive disorders. There are no commercial vaccines against M. bovis in Europe, therefore, experimental ones are still under investigation. The aim of this study was to evaluate the effect of experimental M. bovis vaccine, containing the Polish field M. bovis strain as well as saponin and lysozyme dimer adjuvants, on the T- and B-cell response in calves.

Material and Methods: The study was carried out on 12 calves divided into two equal groups: experimental and control. The experimental group was subcutaneously injected with the vaccine composed of the field M. bovis strain as well as saponin and lysozyme dimer as adjuvants, whereas the control one received phosphate buffered saline (PBS). The blood samples were collected prior to the study (day 0), then in 24 h intervals up to day 7 and then each 7 days until day 84 post immunisation. The T- and B-cell response as CD2+ (T-cells), CD4+ (T-helper cells), CD8+ (T-cytotoxic cells), and WC4+ (B-cells) markers was analysed using flow cytometry.

Results: In response to the immunisation, the general stimulation of T-cell was observed, the most seen in an increase in CD8+ subpopulation. Similarly, a visible rise in the percentage of WC4+ cells was registered in the vaccinated calves when compared to the control animals.

Conclusion: This study demonstrated that the novel experimental M. bovis vaccine containing saponin and lysozyme dimer effectively stimulated the cell-mediated immunity in the calves.
Kant on the Necessity of Causal Relations
Authors: Kannisto Toni
Published: December 2017

There are two traditional ways to read Kant’s claim that every event necessarily has a cause: the weaker
Thoughts on the origin, progress, and pronominal status of reciprocal forms in Germanic, occasioned by those of Bavarian
Authors: Plank Frans
Published: December 2017

Grammaticalised reciprocal markers in Germanic derive from combinations of a quantifier and the alterity word ‘other’, elaborating on a minimalist strategy of identical NP repetition suggesting rather than expressing reciprocity (‘earl[s] hated earl[s]’). Subserved by quantifier floating, they develop fromfree to tighter syntactic combinations and eventually intomorphological units, tending towards complete inflectional deactivation. Sooner or later in all Germanic languages, the quantifier part of the reciprocal gets inside prepositional phrases (‘earls fought each/one with other’> ‘earls fought with each/one other’). German continues this fusional theme by combining the reciprocal with prepositions in compounds; and in Bavarian it eventually gets reduced further to a bound stem limited to (partly lexicalised) combinations with a preposition, thus being barred from the direct object relation, unlike the reflexive. In tracing this overall diachronic scenario, the question is raised of the pronominality (or pro-NP-hood) of reciprocals in Germanic. It is argued that, regardless of their nominal and referential source, reciprocals here strongly incline towards becoming adverbs of attenuated, situational rather than personal reference, highlighting the relational (role reversal) rather than the (co-)referential component of reciprocity, as is common also elsewhere.
Potential Valuation of Route Prague – Trutnov after D11 Completion
Authors: Hašek Jakub , Hruška Roman , Vasiliauskas Aidas Vasilis
Published: December 2017

In the Czech Republic, there are many regions with unbalanced competition between bus and rail transport on main transport routes. This is due to differences in the quality of transport infrastructure, the attractiveness of the region, routing traffic routes or economic attractiveness for new investors and industry. The aim of this article is to evaluate the potential for bus operators on the route from Prague to Trutnov after completion of D11 highway project.