bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Relationship of Image Formation on Tourist Satisfaction and Loyalty: Evidence From China
Authors: Jebbouri Abdelhamid , Zhang Heqing , Wang Lei , Bouchiba Nasser
Published: November 2021

Cultural heritage tourist destinations have emerged as a hot topic in tourism literature, but there have been relatively few studies that determine the role of the involvement of local participation in either tourism planning or the decision-making processes of tourists. The connection between local community participation (LCP), authenticity, access to local products, destination visit image, tourist satisfaction, and tourist loyalty is thus relatively unexplored in the literature. This study used a quantitative approach based on a survey with 406 respondents visiting the city of Kaiping in Guangdong, China. The proposed hypotheses were empirically tested with SPSS and Analysis of Moment Structures. The resulting outcomes indicated a positive correlation between LCP, authenticity, and access to local and destination visit image, which led to tourist satisfaction and ultimately resulted in tourist loyalty. Additional theoretical contributions, practical implications, and limitations were also discussed.
Role of Reputation in Sustainable Performance of Online Crowdsourcing Vendors: An Explanation From Transaction Cost Theory
Authors: Han Xiao , Xue Mengxiao , Song Wenhui
Published: November 2021

This study reveals a new finding on the impact of reputation growth on crowdsourcing vendors’ sustainable performance in different modes of markets using fixed-effect panel data regression models. To this end, we extract data from a large Chinese crowdsourcing platform namedzbj.comfor the period of 2012–2014, which was a key stage for the establishment of market diversification. Based on different transaction modes, the study divides the markets on the crowdsourcing platform into task-based market (TBM) and employment market (EPM). By applying the multiple framework, the empirical results exhibit a negative and significant effect of vendors’ reputation on participation rate (PR) in TBM and EPM. At the same time, reputation also has a consistent effect on vendors’ revenue share (RS) of each market. Moreover, this study shows that the significant reputation impact on PR and RS of EPM will be, respectively, weakened and strengthened in fixed-price mode and customized mode when vendors participate more in large-scale projects. The findings suggest that the growth of reputation will promote market transfer of vendors, that is, showing different sustainability in different markets, which will lead to uneven development of the crowdsourcing markets. By adopting the perspective of transaction cost theory (TCT), this study elaborates and analyses these phenomena and derives corresponding policy implications.
Mobile Phone Addiction and Academic Procrastination Negatively Impact Academic Achievement Among Chinese Medical Students
Authors: Tian Jing , Zhao Ji-yang , Xu Jia-ming , Li Qing-lin , Sun Tao , Zhao Chen-xi , Gao Rui , Zhu Li-yan , Guo Hai-chen , Yang Li-bin , Cao De-pin , Zhang Shu-e
Published: November 2021

The problem of mobile phone addiction and academic procrastination among medical students has been widely acknowledged. This study aimed to explore the influence of demographic factors on mobile phone addiction, academic procrastination, and academic achievement among medical students. Further, it investigated the association between mobile phone addiction, academic procrastination, and academic achievement. This cross-sectional study was conducted between May and June 2019. A total of 3 511 medical students participated in an online questionnaire survey (effective response rate = 81.7%). Demographic factors, the Scale of Academic Achievement, the short scale of the Mobile Phone Problem Use (MPPUS-10), and the Academic Procrastination Scale–Short (APS-S) were used. Hierarchical multiple regression analysis revealed that the average scores for academic procrastination, mobile phone addiction, and academic achievement were 2.66 ± 0.91, 5.13 ± 1.53, and 4.51 ± 0.71, respectively. Moreover, there were significant differences in gender, grade, leadership experience, and family monthly income across mobile phone addiction, academic procrastination, and academic achievement. Mobile phone addiction was negatively associated with learning dedication, learning performance, and relationship facilitation. Academic procrastination was negatively associated with learning dedication, learning performance, relationship facilitation, and objective achievement. Mobile phone addiction and academic procrastination was revealed as prevalent among Chinese medical students, and negatively influences their academic achievement. It is critical to establish a more efficient learning environment for Chinese medical students to minimize the negative impact of mobile phone addiction and academic procrastination.
Why Studies in the Effect of Positive Psychological Interventions Should Use Life-Satisfaction as an Outcome
Authors: Veenhoven Ruut
Published: November 2021

The effect of positive psychological interventions (PPIs) is mostly assessed using self-report measures of positive mental health. These measures are problematic because (1) the content addressed is often not clear, (2) different scales are used to assess different notions of positive mental health, which impedes comparability, (3) the concept of positive mental health involves objective capabilities which are not well measurable using subjective self-estimates, and (4) the concept behind the measures denotes presumed chances for adaptation to life rather than adaptation as such. Therefore, we should also measure the effect of PPIs using life-satisfaction, which is (a) a clear-cut concept and as such tells us what an intervention brings about, (b) is well measurable using self-reports, since it is a subjective concept, (c) it allows better comparability across studies, and (d) it indicates actual adaptation to life instead of strengthening of presumed of chances for adaptation.
Evaluation of the Virtual Economic Effect of Tourism Product Emotional Marketing Based on Virtual Reality
Authors: Talafubieke Manati , Mai Sheng , Xialifuhan Nuermila
Published: November 2021

Rapid development of Internet technology has led to great changes in all fields of life. Tourism industry has also gone to the Internet with the change of the times. Regarding the application of Internet technology in tourism, in fact, virtual tourism products are directly used to promote economic development. Online tourism stores have all kinds of tourism information in the database, realize network roaming, provide convenient information services for both the supply and demand of tourism, and can realize the rapid and stable sustainable development of tourism. This article mainly studies the evaluation of the virtual economic effect of emotional marketing of tourism products based on virtual reality (VR), the meaning algorithm of VR, etc., analyzes the virtual economy of tourism products based on VR, and helps tourism enterprises to grasp the needs of tourism consumers more accurately, so as to design products and services that are more in line with the demands of tourism consumers, the process of ultimately improving the user value. This study mainly uses the VR method, VR platform eye map processing, VR eye map regional detection and feature extraction method, and VR tourism product emotional marketing related experiments, to study the evaluation of the virtual economic effect of tourism product emotional marketing based on VR. The economic performance information of the virtual tourism industry is equivalent to the amount of these indicators, and the impact of the comprehensive evaluation on the economic performance of virtual tourism is quite equal. The results show that from 2017 to 2020, the virtual economic revenue of VR tourism product emotional marketing increased from 50 million to 1 billion. However, people give more importance to the tourism experience brought by virtual tourism products, and the reasonable consumption structure of virtual tourism hinders the improvement of tourism economic benefits. To promote the rationalization of the consumption structure of virtual tourism, the basic industry of tourism consumption is developed and the necessary design and processing is increased, in order to increase the supply of tourism products and to enrich tourism consumption.
Sustainable Digital Economy Through Good Governance: Mediating Roles of Social Reforms and Economic Policies
Authors: Xianbin Tang , Qiong Wu
Published: November 2021

The most powerful and crucial concept today is a sustainable digital economy. This research is aimed to investigate the predictors of a sustainable digital economy in China. In addition, the mediating roles of social reforms and economic policies were investigated between good governance and a sustainable digital economy. This cross-sectional research considered partial least square–structural equational modeling (PLS-SEM) as an analysis technique. The data were collected from 317 managerial staff of the e-commerce industry in China via a self-structured questionnaire. A random sampling technique was applied in the data collection process. Results showed that good governance positively impacts the sustainable digital economy, social reforms, and economic policies. Additionally, an increase in social reforms and economic policies led to a sustainable digital economy in China. Social reforms and economic policies partially mediated the relationship between good governance and a sustainable digital economy. This research contributes to the body of knowledge by identifying components of a sustainable digital economy and examining whether good governance may aid in attaining a sustainable digital economy. Nowadays, research on the sustainable digital economy has got attention from policymakers and researchers around the globe. These outcomes suggest several ways to improve the sustainable digital economy in China. This research is not without limitations, such as cross-sectional and based on responses of the respondents. Several research avenues were discussed and can be influenced by many factors for future perspectives.
The Boss’s Long Arm: The Differential Impact of Authoritarian and Benevolent Leadership on Spousal Family Satisfaction
Authors: Yao Lei , Xu Minya , Pellegrini Ekin K.
Published: November 2021

The extant studies on leadership are replete with employee, coworker, and leader outcomes, however, research is still nascent on leadership’s crossover into employees’ family members’ lives. To examine leadership’s impact on the work–family interface, we draw on conservation of resources theory (COR) and crossover theory and investigate how authoritarian leadership and benevolent leadership affect spousal family satisfaction. We examine the mediating influence of work–family conflict (WFC) and work-family facilitation (WFF), and the moderating impact of spouses’ need for control. Our model was tested with multisource, mutiwave data from 207 Chinese married dyads. The results suggest that, as expected, the positive relationship between benevolent leadership and spousal family satisfaction is fully mediated by WFF, and the negative relationship between authoritarian leadership and spousal family satisfaction is fully mediated by WFC. Findings further suggest that the negative relationship between employee WFC and spousal family satisfaction is stronger for spouses with a higher need for control. Thus, authoritarian leadership, through its negative influence on WFC appears to be universally detrimental for spousal family satisfaction, however, even more so for spouses with a higher need for control. These results underscore the importance of acknowledging leadership’s impact at work reaching far beyond the job incumbent.
National Culture and Culinary Exploration: Japan Evidence of Heterogenous Moderating Roles of Social Facilitation
Authors: Liu Bin , Wang Yang , Katsumata Sotaro , Li Yulei , Gao Wei , Li Xi
Published: November 2021

This article explores the role of national culture in the culinary consumption behavior of international tourists and the moderating influence of different types of travel companions. Study 1 adopted a text-mining, topical modeling approach to process useful reviews (n = 7,803) posted at TripAdvisor by users from 86 countries. Study 2 develops and tests a conceptual model of the relationships between national culture and culinary choices including culinary types and range of culinary choices, based on a secondary dataset of large-scale surveys from the tourism authority of the destination containing 9,141 responses by tourists from over 60 countries or regions. The results reveal that both Uncertainty Avoidance and Individualism-Collectivism have significant effects on tourist food consumption categories and the range of culinary choices. The study also evaluated the role of the moderating effect of travel companions, and results supported the significant relationship on the range of culinary choices when the tourists were accompanied by different types of travel companions.
Does Exposure to General Anesthesia Increase Risk of ADHD for Children Before Age of Three?
Authors: Song Junjie , Li Huifang , Wang Ying , Niu Chenguang
Published: November 2021

Objective: The objective of the study was to evaluate the relationship between frequency of exposure to general anesthesia before the age of 3 and subsequent risk of diagnosis for attention-deficit hyperactivity disorder (ADHD).

Method: We searched PubMed, Embase, Web of Science, and Cochrane Library database for eligible inclusion in the meta-analysis. The indicated outcomes were extracted from the included studies, and the combined effects were calculated using the RevMan software 5.3.

Results: Compared with no exposure to general anesthesia, single exposure to general anesthesia did not increase the risk of ADHD for children before the age of 3 [hazard ratio (HR): 1.14, 95%; confidence intervals (CI): 0.97–1.35; p = 0.11; I2 = 0%], while multiple exposures to general anesthesia did increase the risk of ADHD (HR: 1.83; 95% CIs: 1.00–3.32; p = 0.05; I2 = 81%).

Conclusion: Multiple, but not single, exposures to general anesthesia in children before age of 3 increased the risk of ADHD.
Nutrition in Skin Picking Disorder and Trichotillomania
Authors: Grant Jon E. , Valle Stephanie , Chamberlain Samuel R.
Published: November 2021

Objective: Excessive calorie intake constitutes a global public health concern, due to its associated range of untoward outcomes. Impulsivity and compulsivity have been linked to dietary intake. However, nothing is known about dietary intake and body-focused repetitive behaviors, despite their classification as obsessive-compulsive related conditions, and high co-morbidity with impulsive and compulsive conditions.

Methods: One hundred and ninety six adults with trichotillomania or skin picking disorder were recruited. Dietary intake over the preceding year was quantified using the Dietary Fat and Free Sugar Short questionnaire. Relationships between dietary fat/sugar intake and behaviors were evaluated using regression modeling.

Results: Sugar intake was significantly related to higher trans-diagnostic compulsivity (p = 0.011) and higher non-planning impulsivity (p = 0.013) In terms of saturated fat intake, there was no significant relationship to the explanatory variables. A combination high fat/high sugar diet was significantly associated with higher motor impulsivity (p = 0.005).

Conclusions: Past-year nutrition appears to be significantly associated with trans-diagnostic impulsivity and compulsivity. The role of poor nutrition in these disorders and related conditions, and its link with impulsivity and compulsivity, requires longitudinal research attention; and clinical work should address not only psychiatric symptoms but also impact of lifestyle of overall health.
The Relationship Between Cognitive Dysfunction Through THINC-Integrated Tool (THINC-it) and Psychosocial Function in Chinese Patients With Major Depressive Disorder
Authors: Han Han , Hou Yanyan , Yao Shuqiao , Hu Shaohua , Zhou Qi , Yu Xin , McIntyre Roger S. , Shi Chuan
Published: November 2021

Background: Herein, we validate the psychometric properties of the Chinese version of the THINC-integrated tool (THINC-it) as a screening tool for cognitive deficits in patients with major depressive disorder. The primary aim of this study is to determine whether cognitive deficits as detected by the THINC-it tool in adults with major depressive disorder (MDD) are associated with workplace productivity and/or psychosocial function.

Methods: Subjects aged 18–65 (n = 91) with MDD were evaluated and compared to age-, sex- and education- matched healthy controls (n = 95). Symptoms of cognitive dysfunction, workplace productivity, and psychosocial function were measured using the THINC-it tool, Hamilton Depression Scale (HAMD), Sheehan Disability Scale (SDS), The Work Productivity and Activity Impairment questionnaire- Specific Health Problem (WPAI-SHP).

Results: There were significant differences in THINC-it scores (p < 0.01), the average of HAMD total score (p < 0.01) and all aspects of SDS (p < 0.01) between two groups. There were significant differences in the four aspects of WPAI between the two groups in the employed status (p <0.01). THINC-it subjective cognition and SDS total score, SDS work/school, SDS social, SDS family showed significantly correlation (r ranging from 0.255 to 0.386, p <0.01). SDS and THINC-it Objective cognition, THINC-it comprehensive cognition were no correlation between two groups. HAMD total score and SDS total score, SDS social, SDS family showed significantly correlation (r ranging
Impact of the COVID-19 Pandemic on Cancer Researchers in 2020: A Qualitative Study of Events to Inform Mitigation Strategies
Authors: Fox Louis , Beyer Katharina , Rammant Elke , Morcom Esme , Van Hemelrijck Mieke , Sullivan Richard , Vanderpuye Verna , Lombe Dorothy , Tsunoda Audrey Tieko , Kutluk Tezer , Bhoo-Pathy Nirmala , Pramesh Shanmugham C. , Yusuf Aasim , Booth Christopher M. , Shamieh Omar , Siesling Sabine , Mukherji Deborah
Published: November 2021

Introduction: The COVID-19 pandemic has had an unprecedented impact on global health systems and economies. With ongoing and future challenges posed to the field due to the pandemic, re-examining research priorities has emerged as a concern. As part of a wider project aiming to examine research priorities, here we aimed to qualitatively examine the documented impacts of the COVID-19 pandemic on cancer researchers.

Materials and Methods: We conducted a literature review with the aim of identifying non-peer-reviewed journalistic sources and institutional blog posts which qualitatively documented the effects of the COVID-19 pandemic on cancer researchers. We searched on 12th January 2021 using the LexisNexis database and Google, using terms and filters to identify English-language media reports and blogs, containing references to both COVID-19 and cancer research. The targeted search returned 751 results, of which 215 articles met the inclusion criteria. These 215 articles were subjected to a conventional qualitative content analysis, to document the impacts of the pandemic on the field of cancer research.

Results: Our analysis yielded a high plurality of qualitatively documented impacts, from which seven categories of direct impacts emerged: (1) COVID measures halting cancer research activity entirely; (2) COVID measures limiting cancer research activity; (3) forced adaptation of research protocols; (4) impacts on cancer diagnosis, cases, and services; (5) availability of resources for cancer research; (6) disruption to the private sector; and (7) disruption to supply chains. Three categories of consequences from these impacts also emerged: (1) potential changes to future research practice; (2) delays to the progression of the field; and (3) potential new areas of research interest.

Discussion: The COVID-19 pandemic had extensive practical and economic effects on the field of cancer research in 2020 that were highly plural in nature. Appraisal of cancer research strategies in a post-COVID world should acknowledge the potential for substantial limitations (such as on financial resources, limited access to patients for research, decreased patient access to cancer care, staffing issues, administrative delays, or supply chain issues), exacerbated cancer disparities, advances in digital health, and new areas of research related to the intersection of cancer and COVID-19.
The Influencing Factors of Nutrition and Diet Health Knowledge Dissemination Using the WeChat Official Account in Health Promotion
Authors: Bian Dongsheng , Shi Yongmei , Tang Wenjia , Li Dong , Han Kangni , Shi Chenshu , Li Guohong , Zhu Fan
Published: November 2021

Background: The promotion of a healthy diet via health education is a component of the “Healthy China 2030” plan. However, few studies have reported whether health knowledge about nutrition and diet has gained public attention, and whether it is needed by the public.

Methods: The numbers of views, shares, and reads of articles published by the official WeChat account of a hospital in China were accessed. The influence index was obtained via the entropy analysis of these three indices. A questionnaire survey was developed based on the purpose of the study and the conclusion of the content analysis, which conducted to analyze users' requirements for health knowledge and their influencing factors. Moreover, risk factors were explored by logistic regression models.

Results: Of the 103 articles considered in this study, four articles in the Top 10 were related to nutrition and diet. The influence index of nutrition and diet knowledge was found to be the highest in the content analysis (p < 0.05). The higher degrees of humor (β = 0.224, p = 0.027), nutrition and diet articles (β = 0.776, p = 0.034), and cover articles (β = 0.312, p = 0.021) have significant influences on the influence index. In total, 581 questionnaires were obtained, and 78.1% of the respondents reported believing that the health knowledge of greatest concern was that related to nutrition and diet. Multivariate logistic regression analyses were conducted to explore the associations between the features of the articles and users reading nutrition and diet knowledge; it was found that gender (female, OR: 4.651, 95%Cl: 2.598, 8.325, and p < 0.001), age (young adult, OR: 0.358, 95%Cl: 0.266, 0.481, and p < 0.001), cancer precaution knowledge (OR: 4.333, 95%Cl: 2.262, 8.299, and p < 0.001), traditional Chinese medicine (OR: 2.121, 95%Cl: 1.064, 4.230, and p = 0.033), the knowledge acquisition approach [circle of friends (OR: 2.586, 95%Cl: 1.373, 4.868, and p = 0.003), social media (OR: 2.183, 95%Cl: 1.204, 3.960, and p = 0.010)), hospitals (OR: 3.194, 95%Cl: 1.793, 5.692, and p < 0.001), television media (OR: 4.348, 95%Cl: 2.341, 8.077, and p < 0.001)], and social media strategies [professionalism and authority (OR: 2.354, 95%Cl: 1.231, 4.505, and p = 0.006)] have statistically significant relationships with users reading nutrition and diet knowledge.

Conclusion: Nutrition and diet knowledge could contribute to WeChat user engagement of health information dissemination. Nutrition professionals should improve the scientific popularization ability and effectively use social media for health promotion.
Effects of SO2 Pollution on Household Insurance Purchasing in China: A Cross-Sectional Study
Authors: Wang Ren , Zhang Lizhi , Tang Ting , Yan Fei , Jiang Dawei
Published: November 2021

There have been considerable concerns regarding the effects of air pollution on health and economy over the past decades across the world. As insurance coverage has been closely related to household welfare, we aim to investigate the influence of air pollution, in particular, the sulfur dioxide (SO2) pollution on household purchases of commercial health insurance using data from the 2017 China Household Financial Survey (CHFS). The results show that the rise in SO2emission has a significant positive association with tendency of residents to participate in commercial health insurance. The possibility of household commercial health insurance purchasing increases by 4% per 1,000 tons of SO2emission. In addition, the proportion of commercial health insurance expenditure in household annual income increases by 29% per 1,000 tons of SO2emission. The effects are also found to differ among resident groups. Residents in eastern parts of China are more likely to buy commercial health insurance facing SO2pollution compared to those in western parts of China; people with higher income are more likely to be affected compared to those with lower income; families with the household head being female are more likely to be affected compared to those with the household head being male. This research provides baseline information on the formulation and implementation of future operation strategy in commercial health insurance companies of China.
Assessing the Role of Collective Efficacy Beliefs During Participative Occupational Health Interventions
Authors: Kuchenbaur Marco , Peter Richard
Published: November 2021

Background: For group-based participatory interventions in the context of occupational health, no questionnaires exist to assess the participants' active engagement in the interventions. On the basis of the construct of collective efficacy beliefs, this study has developed a questionnaire with which the group-related efficacy beliefs can be assessed as a precondition for participants actively engaging in participative interventions.

Methods: Participants were drawn from a two-arm cluster-randomized intervention study to fill out the questionnaire. A Factor analysis and an initial psychometric calibration were performed. In a second step, the group-related properties of the questionnaire were validated using a Multilevel analysis.

Results: The factorial structure of the questionnaire is consistent with the theory of efficacy beliefs according to A. Bandura. Furthermore, the collective efficacy expectations of the interventions' participants are lowered in the absence of appreciation and support in the psychosocial environment of the worksite.

Conclusions: Assessing participant's quality of interventional activity in participatory interventions by collective efficacy can be valuable in understanding the amount of interventional activity. In addition, it is recommended to consider the influence of the worksite's psychosocial environment on collective efficacy beliefs when implementing participatory interventions.

Clinical Trial Registration: Registration trial DRKS00021138 on the German Registry of Clinical Studies (DRKS), retrospectively registered on 25 March, 2020.
Creative AI and Musicking Robots
Authors: Vear Craig
Published: November 2021

This article discusses the creative and technical approaches in a performative robot project called “Embodied Musicking Robots” (2018–present). The core approach of this project is human-centered AI (HC-AI) which focuses on the design, development, and deployment of intelligent systems that cooperate with humans in real time in a “deep and meaningful way.”1 This project applies this goal as a central philosophy from which the concepts of creative AI and experiential learning are developed. At the center of this discussion is the articulation of a shift in thinking of what constitutes creative AI and new HC-AI forms of computational learning from inside the flow of the shared experience between robots and humans. The central case study (EMRv1) investigates the technical solutions and artistic potential of AI-driven robots co-creating with an improvising human musician (the author) in real time. This project is ongoing, currently at v4, with limited conclusions; other than this, the approach can be felt to be cooperative but requires further investigation.
Characterization of Sustainable Robotic Materials and Finite Element Analysis of Soft Actuators Under Biodegradation
Authors: Nagai Toshiaki , Kurita Ashitaka , Shintake Jun
Published: November 2021

Biodegradability is an important property for soft robots that makes them environmentally friendly. Many biodegradable materials have natural origins, and creating robots using these materials ensures sustainability. Hence, researchers have fabricated biodegradable soft actuators of various materials. During microbial degradation, the mechanical properties of biodegradable materials change; these cause changes in the behaviors of the actuators depending on the progression of degradation, where the outputs do not always remain the same against identical inputs. Therefore, to achieve appropriate operation with biodegradable soft actuators and robots, it is necessary to reflect the changes in the material properties in their design and control. However, there is a lack of insight on how biodegradable actuators change their actuation characteristics and how to identify them. In this study, we build and validate a framework that clarifies changes in the mechanical properties of biodegradable materials; further, it allows prediction of the actuation characteristics of degraded soft actuators through simulations incorporating the properties of the materials as functions of the degradation rates. As a biodegradable material, we use a mixture of gelatin and glycerol, which is fabricated in the form of a pneumatic soft actuator. The experimental results show that the actuation performance of the physical actuator reduces with the progression of biodegradation. The experimental data and simulations are in good agreement (R2value up to 0.997), thus illustrating the applicability of our framework for designing and controlling biodegradable soft actuators and robots.
Design of Sustainable Renewable-Based Utility Plants in the Face of Uncertainty
Authors: Pérez-Uresti Salvador I. , Martín Mariano , Jiménez-Gutiérrez Arturo
Published: November 2021

This work presents the formulation of a two-stage stochastic mixed-integer linear programming (MILP) model to include uncertainty in the design of renewable-based utility plants. The model is based on a superstructure that integrates technologies to process biomass, waste, solar radiation, and wind and considers uncertainty in availability of the renewable resources and on the utility demands. The uncertain parameter space is calculated based on a monthly probability density function for each uncertain parameter and discretized into different levels. It is shown that as uncertainty is considered in the model formulation, design flexibility improves with respect to the deterministic-based designs, although the flexibility is achieved at the expense of higher underused facilities and therefore unused investment cost.
Treatment Outcomes and the Safety of Chemoradiotherapy With High-Dose CDDP for Elderly Patients With Head and Neck Squamous Cell Carcinoma: A Propensity Score Matching Study
Authors: Omata Jo , Ueki Yushi , Takahashi Takeshi , Shodo Ryusuke , Yamazaki Keisuke , Saijo Kohei , Ota Hisayuki , Togashi Takafumi , Sato Yuichiro , Horii Arata
Published: November 2021

Objective: We aimed to compare the outcomes and safety of chemoradiotherapy (CRT) between elderly and non-elderly patients with head and neck squamous cell carcinoma (HNSCC). It is difficult to assess the causal effect of age because of possible differences in general conditions among individuals. Therefore, we adjusted the background factors of elderly and non-elderly patients using propensity score matching (PSM).

Methods: A total of 146 patients with HNSCC who received CRT were divided into an elderly (≥70 years, n = 35) and non-elderly group (<70 years, n = 111). Pre-treatment characteristics, including the performance status, Charlson comorbidity index, body mass index, primary site, and TNM stage were adjusted by PSM. We compared the outcomes and safety of CRT with high-dose single-agent cisplatin (CDDP) as well as outcomes following recurrence between the groups, before and after PSM.

Results: The total dose of CDDP administered during CRT was significantly lower in the elderly group before PSM. However, it became comparable to the non-elderly group and adverse events did not differ between the groups following PSM, resulting in a comparable CRT completion rate. Overall-, disease specific-, and progression-free survivals of elderly patients were comparable to those of non-elderly patients following PSM. In contrast, elderly patients with recurrence could receive fewer salvage treatments than their non-elderly counterparts, resulting in worse survival.

Conclusions: CRT with high-dose CDDP is safe and effective for the treatment of elderly patients with HNSCC. However, salvage treatments can be rarely conducted for elderly patients with a recurrence, considering a deterioration of their general condition.
Multivariate Analysis and Validation of the Prognostic Factors for Skull Base Chordoma
Authors: Teng Chubei , Yang Qi , Xiong Zujian , Ye Ningrong , Li Xuejun
Published: November 2021

Background: Skull base chordoma is a rare tumor with low-grade malignancy and a high recurrence rate, the factors affecting the prognosis of patients need to be further studied. For that, we investigated prognostic factors of skull base chordoma through the database of the Surveillance, Epidemiology, and End Results (SEER) program, and validated in an independent data set from the Xiangya Hospital.

Methods: Six hundred and forty-three patients diagnosed with skull base chordoma were obtained from the SEER database (606 patients) and the Xiangya Hospital (37 patients). Categorical variables were selected by Chi-square test with a statistical difference. Survival curves were constructed by Kaplan–Meier analysis and compared by log-rank test. Univariate and multivariate Cox regression analyses were used to explore the prognostic factors. Propensity score matching (PSM) analysis was undertaken to reduce the substantial bias between gross total resection (GTR) and subtotal resection (STR) groups. Furthermore, clinical data of 37 patients from the Xiangya Hospital were used as validation cohorts to check the survival impacts of the extent of resection and adjuvant radiotherapy on prognosis.

Results: We found that age at diagnosis, primary site, disease stage, surgical treatment, and tumor size was significantly associated with the prognosis of skull base chordoma. PSM analysis revealed that there was no significant difference in the OS between GTR and STR (p = 0.157). Independent data set from the Xiangya Hospital proved no statistical difference in OS between GTR and STR groups (p = 0.16), but the GTR group was superior to the STR group for progression-free survival (PFS) (p = 0.048). Postoperative radiotherapy does not improve OS (p = 0.28), but it can prolong PFS (p = 0.0037). Nomograms predicting 5- and 10-year OS and DSS were constructed based on statistically significant factors identified by multivariate Cox analysis. Age, primary site, tumor size, surgical treatment, and disease stage were included as prognostic predictors in the nomograms with good performance.

Conclusions: We identified age, tumor size, surgery, primary site, and tumor stage as main factors affecting the prognosis of the skull base chordoma. Resection of the tumor as much as possible while ensuring safety, combined with postoperative radiotherapy may be the optimum treatment for skull base chordoma.
Intravesical Chemohyperthermia vs. Bacillus Calmette-Guerin Instillation for Intermediate- and High-Risk Non-muscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis
Authors: Zhao Hongda , Chan Vinson Wai-Shun , Castellani Daniele , Chan Erica On-Ting , Ong William Lay Keat , Peng Qiang , Moschini Marco , Krajewski Wojciech , Pradere Benjamin , Ng Chi-Fai , Enikeev Dmitry , Vasdev Nikhil , Ekin Gokhan , Sousa Alejandro , Leon Juan , Guerrero-Ramos Felix , Tan Wei-Shen , Kelly John , Shariat Shahrokh F. , Witjes J. Alfred , Teoh Jeremy Yuen-Chun
Published: November 2021

Background: The efficacy of intravesical chemotherapy maintenance for patients with non-muscle invasive bladder cancer (NMIBC) is inferior compared to intravesical bacillus Calmette–Guerin (BCG). How intravesical chemohyperthermia (CHT) compares with BCG is under investigation.

Objective: To compare the oncological outcomes and safety profile between intravesical CHT and BCG treatment for intermediate- and high-risk NMIBC.

Methods: We performed a systematic review and meta-analysis of clinical studies comparing CHT with BCG for intermediate- and high-risk NMIBC patients. A comprehensive literature search on OVID MEDLINE, EMBASE, and Cochrane Library was conducted. Risk of bias was assessed by the Cochrane RoB tool and ROBINS-I. Certainty of evidence was rated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) methodology.

Results: A total of 2,375 articles were identified and five studies were finally included. Among them, four randomised trials comprising 327 patients (CHT group: 156 patients; BCG group: 171 patients) were included in the meta-analysis. There were no significant differences in the 24–36 months recurrence rates (CHT: 29.5%, BCG: 37.4%; RR: 0.83, 95% CI 0.61–1.13; moderate certainty of evidence) and the 24–36 months progression rates (CHT: 4.4%, BCG: 7.6%, RR = 0.62, 95% CI 0.26–1.49; low certainty of evidence). There were also no significant differences in grade 1–2 adverse events (CHT group: 59.9%, BCG group 54.5%; RR = 1.10, 95% CI 0.93–1.30; moderate certainty of evidence) and grade 3 or above adverse events (CHT group: 23.2%, BCG group 22.5%; RR = 0.99, 95% CI 0.69–1.43; low certainty of evidence).

Conclusions: Intravesical CHT had equivalent oncological outcomes and similar safety profile when compared to BCG maintenance therapy for patients with intermediate- and high-risk NMIBC. CHT is a possible alternative treatment in the times of BCG shortage.
In vitro and in vivo Effects of a Single Dose of Bupivacaine 5% on Donkey Chondrocytes
Authors: Hussein Kamal , Abdelbaset Abdelbaset Eweda , Sadek Ahmed Abdelrahiem , Noreldin Ahmed
Published: November 2021

Single intra-articular (IA) injection of long-acting local anesthetics such as bupivacaine is commonly used clinically for postoperative analgesia, in particular, after arthroscopic surgery. Despite their widespread use, the side effects of IA bupivacaine on joint cartilage as well as hepatotoxic and nephrotoxic effects remain to be elucidated. The aim of this study is to assess the in vitro effect of bupivacaine 5% on donkey chondrocytes at different time points, in addition to the in vivo effects of a single IA bupivacaine injection on the middle carpal joint in a group of 10 clinically healthy adult male donkeys. In phase I, the effect of in vitro treatment with bupivacaine 5% or saline 0.9% on freshly isolated donkey chondrocytes for 30, 60 min, 24, 48, and 96 h was investigated using MTT and LIVE/DEAD assay. In phase II, in vivo effects of single injection of bupivacaine on the middle carpal joint of the donkey were evaluated compared with saline 0.9%. Biochemical analysis of collected serum and synovia was performed. Additionally, articular cartilage damage was evaluated using radiography, computed tomography (CT), catabolic marker expression via quantitative polymerase chain reaction (qPCR), and histopathological examination 96 h after injection. Our results showed that after a 30-min exposure to bupivacaine 5%, the viability of donkey chondrocytes was 97.3 ± 4.4% and was not significantly affected at the indicated time points (n = 8, p < 0.05). No significant changes in biochemical analytes of serum and synovial fluid following IA bupivacaine injection were observed, compared with saline injection (n = 5 for each group, p < 0.05). Furthermore, in vivo IA injection of bupivacaine revealed no significant differences in radiography, CT scan, gene expression of cartilage catabolic biomarkers, and histopathological examination. These results provide an evidence for the safety of bupivacaine on the donkey cartilage.
Path Planning for Automatic Guided Vehicles (AGVs) Fusing MH-RRT with Improved TEB
Authors: Wang Jiayi , Luo Yonghu , Tan Xiaojun
Published: November 2021

In this paper, an AGV path planning method fusing multiple heuristics rapidly exploring random tree (MH-RRT) with an improved two-step Timed Elastic Band (TEB) is proposed. The modified RRT integrating multiple heuristics can search a safer, optimal and faster converge global path within a short time, and the improved TEB can optimize both path smoothness and path length. The method is composed of a global path planning procedure and a local path planning procedure, and the Receding Horizon Planning (RHP) strategy is adopted to fuse these two modules. Firstly, the MH-RRT is utilized to generate a state tree structure as prior knowledge, as well as the global path. Then, a receding horizon window is established to select the local goal point. On this basis, an improved two-step TEB is designed to optimize the local path if the current global path is feasible. Various simulations both on static and dynamic environments are conducted to clarify the performance of the proposed MH-RRT and the improved two-step TEB. Furthermore, real applicative experiments verified the effectiveness of the proposed approach.
Evaluation of Injection Strategies in Supersonic Nozzle Flow
Authors: Semlitsch Bernhard , Mihăescu Mihai
Published: November 2021

The ability to manipulate shock patterns in a supersonic nozzle flow with fluidic injection is investigated numerically using Large Eddy Simulations. Various injector configurations in the proximity of the nozzle throat are screened for numerous injection pressures. We demonstrate that fluidic injection can split the original, single shock pattern into two weaker shock patterns. For intermediate injection pressures, a permanent shock structure in the exhaust can be avoided. The nozzle flow can be manipulated beneficially to increase thrust or match the static pressure at the discharge. The shock pattern evolution of injected stream is described over various pressure ratios. We find that the penetration depth into the supersonic crossflow is deeper with subsonic injection. The tight arrangement of the injectors can provoke additional counter-rotating vortex pairs in between the injection.
Growth and Bone Development in the Horse: When Is a Horse Skeletally Mature?
Authors: Rogers Chris W. , Gee Erica K. , Dittmer Keren E.
Published: November 2021

Within the lay literature, and social media in particular, there is often debate about the age at which a horse should be started and introduced to racing or sport. To optimize the welfare and longevity of horses in racing and sport, it is important to match exercise with musculoskeletal development and the ability of the musculoskeletal system to respond to loading. The justification for not exercising horses at a certain age is often in contrast to the scientific literature and framed, with incorrect generalizations, with human growth. This review provides a relative comparison of the growth and development of the horse to the descriptors used to define growth and development in humans. Measures of physeal closure and somatic growth demonstrate that the horse completes the equivalent of rapid infant growth by weaning (4–6 months old). At approximately 11 months old, the horse completes the equivalent of the childhood phase of growth and enters puberty. At 2 years old, the horse has achieved most measures of maturity used within the human literature, including the plateauing of vertical height, closure of growth plates, and adult ratios of back length:wither height and limb length:wither height. These data support the hypothesis that the horse evolved to be a precocious cursorial grazer and is capable of athletic activity, and use in sport, relatively early in life.
Growth Performance, Antioxidant Activity, Immune Status, Meat Quality, Liver Fat Content, and Liver Histomorphology of Broiler Chickens Fed Rice Bran Oil
Authors: Selim Shaimaa , Hussein Eman , Abdel-Megeid Nazema S. , Melebary Sahar J. , AL-Harbi Mohammad S. , Saleh Ahmed A.
Published: November 2021

This trial was performed to determine the effect of rice bran oil (RBO) inclusion in diets of broiler chickens on performance, carcass characteristics, blood parameters, meat quality, antioxidant activity, liver lipid content, and liver histological structure. The 35-day feeding trial was conducted on 240 one-day-old Ross 308 broiler chickens, allocated to four treatment groups with six replicates each. RBO was examined at different inclusion levels, 0% (control), 1% (RBO1%), 1.5% (RBO1.5%), and 2% (RBO2%) in a completely randomized design. The results showed that at the end of the trial (35 days) the RBO supplementation had positive effects (p < 0.001) on the productivity parameters, but the feed intake was linearly decreased due to RBO inclusion. In addition, RBO supplementation linearly improved (p < 0.05) the dressing percentage, breast yield, immune organs relative weights, and meat glutathione concentration, while it decreased (p < 0.01) the abdominal fat yield and meat crude fat, triglycerides, cholesterol, and Malondialdehyde (MDA) contents in broiler’s meat. Moreover, serum total protein, globulin, and high-density lipoprotein contents improved noticeably (p < 0.01) due to offering an RBO-supplemented diet, but serum total lipids, total cholesterol, triglyceride, low-density lipoprotein, and aspartate aminotransferase concentrations linearly reduced (p < 0.01). The RBO supplementation augmented (p < 0.05) the phagocytic index, phagocytic activity, and antibody titer compared to control. On the other hand, RBO inclusion had no effect on the breast, thigh, or abdominal fat color parameters. Moreover, RBO supplementation reduced (p < 0.01) the content of total saturated FA (SFA), but increased (p < 0.01) the content of total monounsaturated FA (MUFA), and polyunsaturated FA in both breast and thigh meat. Chemical analysis of the liver tissue samples revealed that the inclusion of RBO linearly reduced (p < 0.05) hepatic cholesterol, triglyceride, and MDA contents. Histologically, the lipid percentage and number of lipid droplets (p < 0.01) were markedly lessened in the RBO-supplemented groups. The histological structure of the liver asses by light and electron microscope were normal in all groups without any pathological lesions. It is concluded that RBO could be used as a valuable ingredient in broiler chickens’ diets to stimulate the growing performance and immune status, enhance the antioxidant activity and blood lipid profile, augment liver function, and improve the nutritive value of the meat.
Diag-Skills: A Diagnosis System Using Belief Functions and Semantic Models in ITS
Authors: Rahmouni Nesrine , Lourdeaux Domitile , Benabbou Azzeddine , Bensebaa Tahar
Published: November 2021

This work is related to the diagnosis process in intelligent tutoring systems (ITS). This process is usually a complex task that relies on imperfect data. Indeed, learning data may suffer from imprecision, uncertainty, and sometimes contradictions. In this paper, we propose Diag-Skills a diagnosis model that uses the theory of belief functions to capture these imperfections. The objective of this work is twofold: first, a dynamic diagnosis of the evaluated skills, then, the prediction of the state of the non-evaluated ones. We conducted two studies to evaluate the prediction precision of Diag-Skills. The evaluations showed good precision in predictions and almost perfect agreement with the instructor when the model failed to predict the effective state of the skill. Our main premise is that these results will serve as a support to the remediation and the feedbacks given to the learners by providing them a proper personalization.