bluuebunny/crossref_metadata_2025 huggingface dataset:
STRATEGI PELAYANAN DALAM PENINGKATAN KEPUASAN JAMAAH UMRAH DISABILITAS PADA PT. DHIYAA EL HARAMAIN EL MUBARAKAH BEKASI JAWA BARAT
Authors: Sirin Khoiron , Soleha Maratus
Published: August 2024

Permasalahan jamaah haji dan umrah yang memiliki keterbatasan fisik dan keterbatasan kemampuan (disabilitas) merupakan permasalahan nasional yang membutuhkan perhatian khusus dari para stakeholder, utamanya perusahaan travel haji dan umrah. Penelitian ini membahas mengenai strategi pelayanan ibadah umrah bagi jamaah yang memiliki keterbatasan fisik (disabilitas) dalam rangka meningkatkan kepuasan bagi mereka. Penelitian ini menggunakan metode studi kasus pada PT Dhiyaa El Harmaian El Mubarakah Bekasi Jawa Barat tahun 2022. Hasil penelitian menunjukan bahwa strategi pelayanan dalam meningkatkan kepuasan jamaah disabilitas pada PT. Dhiyaa El Haramain El Mubarakah sudah tepat. Hal ini dilihat dari strategi pelayanan yang diterapkan mereka baik dari mulai penyambutan jamaah ketika bertanya-tanya, mendaftar, sampai pelaksanaan ibadah umroh diberikan pelayanan secara maksimal dan mereka memprioritaskan jamaah disabilitas baik ketika di tanah air maupun di tanah suci dan tidak membeda-bedakan jamaah disabilitas dengan jamaah normal lainnya. Adapun strategi pelayanan yang dimaksud meliputi pengenalan dan kebiasaan jamaah disablitias, pendampingan khusus bagi jamaah disabilitas, dan pemenuhan kebutuhan khusus bagia jamaah disabilitas.Kata Kunci : Strategi, Pelayanan, Kepuasan, Jamaah, Disabilitas ABSTRACT The problem of Hajj and Umrah pilgrims who have physical limitations or limited abilities (disabilities) is a national problem that requires special attention from stakeholders, especially Hajj and Umrah travel companies. This research discusses Umrah service strategies for pilgrims who have physical limitations or linited abilities (disabilities) in order to increase their satisfaction. This research uses a case study method at PT Dhiyaa El Harmaian El Mubarakah, Bekasi, West Java in 2022. The research results show that the service strategy in increasing the satisfaction of disabled pilgrims at PT. Dhiyaa El Haramain El Mubarakah is correct. This can be seen from the service strategy they implement, from welcoming pilgrims when asking questions, registering, to carrying out the Umrah pilgrimage, providing maximum service and they prioritize disabled pilgrims both in their homeland and in the holy land and do not discriminate against disabled pilgrims. with other normal pilgrims. The service strategy in question includes the introduction and habits of disabled pilgrims, special assistance for disabled pilgrims, and meeting the special needs of disabled pilgrims. Keywords: Strategy, Service, Satisfaction, Pilgrims, Disability
Pentingnya Sertifikasi Haji Untuk Kualitas Pembimbing Haji
Authors: Wulandari Retno
Published: August 2024

AbstractThe writing of this scientific article is intended to explain the importance of Hajj certification for the quality of the Hajj guide. To find out the importance of certification and quality what happens if the Hajj advisor approves.Certification is one of the points in determining the level of professionalism of a person and the assessment of the competence of pilgrims is expected to provide positive energy and the best guidance for pilgrims.Hajj Guidance is a person in the field of Hajj who masters the knowledge of Hajj rituals who have participated in the activities of controlling Hajj and Umrah guides and assigned to guide the pilgrims. To become a guide, the pilgrim must master various competencies and languages and be required to be professional and responsible so as not to question the quality.The quality of conformity with various requirements that have met the requirements to support the need to meet the needs, with the needs made totality formed good quality. Quality Hajj guides are Hajj guides who have received certification and have Hajj certificates.Keywords: Certification, Hajj Guidance, Quality
Ortobiológicos 2024: definición, elaboración y mecanismo de acción de las alternativas más utilizadas hoy en Ortopedia
Authors: Rossi Luciano , Levi Lorena
Published: August 2024

La ortobiología está emergiendo como una nueva subespecialidad de la Ortopedia, con una aceptación gradual. Si bien el primer impulso del uso masivo de las terapias biológicas en Ortopedia vino de la mano del plasma rico en plaquetas y el concentrado de médula ósea por su elaboración y aplicación fáciles; en la última década, se han producido avances importantes y ha surgido numerosa evidencia clínica sobre los resultados de otras terapias biológicas prometedoras, como el lisado plaquetario, las célulasmesenquimales derivadas del tejido adiposo y los cultivos celulares. Este artículo tiene como objetivo describir las terapias biológicas más utilizadas actualmente en Ortopedia, con especial énfasis en su proceso de elaboración, su composición y mecanismo de acción.
Mitral valve plastic surgery with an autopericardial strip: finite element modeling
Authors:   Nizhny Novgorod State Technical University, Mironov Anatoly , Ryazanov Mikhail ,   Specialized Cardiac Surgical Clinical Hospital, Kikeev Vasily , Zhilcov Dmitry
Published: August 2024

Currently, one of the methods of treatment of ischemic mitral insufficiency, leading to blood regurgitation, is annuloplasty surgery. In medical practice, MitraClip procedures and the installation of various types of rings have become widespread, ensuring reliability, biocompatibility and high manufacturability of the operation. In this paper, a modified annuloplasty using a pericardial strip is considered. A common problem of performing such operations is predicting their results depending on the correction parameters. Finite element modeling is used to solve this problem. As part of the study, a finite element model of the mitral valve was developed in the environment of the LS-DYNA software product, which allows for imitation of plastic surgery with a pericardial strip. The model is constructed using shell elements and includes valve flaps, a fibrous ring and chords. The change in the tension forces of the chords and the dilation of the fibrous ring are carried out respectively by the imposition of kinematic and force boundary conditions, which persist even after the plastic surgery. The pericardial strip, sewn to the back of the fibrous ring, is modeled by elements of a flexible thread with the possibility of pre-tensioning. The mechanical properties of the pericardium used in computer modeling were obtained from the results of tensile testing of samples. The results of a computational experiment of the effect of the pericardial strip plasty procedure on the restoration of valve leaf co-optation in the presence of dilation of the posterior part of the fibrous ring are presented. After correction according to the diagnostic data of a particular patient, the model can be used to select the necessary strip sizes during mitral valve repair surgery.
(in)Vulnerable Masculinity: Men's Narration and Identity when Experiencing Violence from a Female Partner
Authors:   , Hansén Caroline
Published: August 2024

The complex realm of intimate partner violence (IPV) against men by female partners continues to be under-researched in Sweden. The lack of knowledge and recognition regarding the impacts and dimensions of violence that men face can severely affect their self-perception and masculinity. The thesis is anchored in the objective to describe and analyse men’s lived experiences of (diverse dimensions of) violence perpetrated by a female partner, the men’s reactions to their experiences, and what subsequent effects these experiences have on their sense of self and masculinity. Employing a narrative methodology, the study captures the experiences of 21 men to illuminate the complexities of male vulnerability and victimhood. Although no man explicitly voiced being a victim of IPV, the men’s narratives implicitly convey the essence of being subjected to something and indicate that the men’s experiences do not fit with the public and prevailing narratives of gender and IPV. The thesis employs a hermeneutical approach to delve into the men’s narratives, integrating theoretical frameworks on masculinity, liminality, possible self, and the concepts of epistemic injustice, definitional hegemony, and definitional dialogue. These concepts frame the men’s struggle for recognition and understanding within societal and authoritative contexts, where their experiences often clash with prevailing narratives of gender, IPV, and institutional biases. The findings portray the men’s efforts to reconcile traditional masculinity while they are in limbo and trying to (re)construct their sense of self. The intricate dance between outward perception and inner turmoil invites a critical re-evaluation of complicit masculinity within the realm of IPV, urging a departure from rigid masculine archetypes towards a more inclusive, empathetic understanding of masculinity that embraces the multifaceted realities of these men’s lives. Such findings have led to the development of the concept of piloting masculinity, which illustrates the men’s trajectory of entering and leaving liminality, while reconstructing their identities into a new possible self and embracing vulnerability. This thesis provides a comprehensive understanding of the men’s lived experiences, challenging conventional gender narratives and highlighting the need for a more inclusive discourse on IPV that acknowledges male victims. It emphasises the necessity for systemic changes in order to recognise and support men better through IPV and its aftermath.
Design and Simulation of Frequency-Hop for 2.4 GHz Wireless Communication System
Authors: Dubey Poornanand . , Shukla Nitesh
Published: August 2024

FHSS is a component of spread spectrum technology. FHSS uses Industrial, Scientific and Medical (ISM) waveband for communication which is license free [4]. FHSS Transceiver model provide secure communication over the trail of communication. Its robustness against third party interception is thanks to use of PN sequencegenerator.supportedtheintroductionof frequency-hopping communication system andits mathematic model, a simulation model was built using MATLAB. This paper researches the issues of a recurrence bouncing spread range (FHSS)and manages usage byndby.TheFHSS procedure is valuable for stifling obstruction, making capture attempt troublesome, obliging blurring and multipath channels, and giving a numerous entrance ability. The beneficiary demodulates the got signal by the transporter frequencies that change simultaneously depending on a similar recurrence bouncing arrangement and makes an identification of it.
Data Security in Foreign Computing: Cloud Solutions and their Impact on Cross-Border Data Integrity
Authors: Tiwari Shivam , Vishwakarma Abhishek , Patel Vivek , Jain Pragati
Published: August 2024

The rapid expansion of foreign computing environments and the increasing cross-border flow of data have intensified the challenges of maintaining data security, integrity, and confidentiality. Cloud computing has emerged as a viable solution to these challenges by offering scalable and cost-effective storage and processing capabilities. This study explores data security issues within foreign computing contexts and evaluates the effectiveness of cloud-based solutions. The proposed method leverages advanced security features, such as encryption, access controls, and zero-trust architecture, to enhance data protection. The evaluation of this method demonstrated an accuracy of 97.6%, a mean absolute error (MAE) of 0.403, and a root mean square error (RMSE) of 0.203, highlighting its effectiveness in mitigating data security risks. By examining case studies and recent advancements in cloud security technologies, this research provides actionable insights for organizations aiming to bolster their data security measures in an increasingly globalized digital landscape.
Assessing the Efficacy of Machine Learning
Models for Data Security in Public Cloud
Computing: Accuracy and Error Performance
Authors: Tiwari Shivam , Sharma Saurabh , Hasan Zohaib
Published: August 2024

The evolution of public cloud computing has revolutionized data management by offering significant
benefits in scalability, flexibility, and cost-effectiveness. Despite these advantages, the shift to cloud-based solutions
has introduced considerable data security challenges, such as unauthorized access, breaches, and stringent regulatory
compliance. Conventional security measures often fall short in effectively addressing these dynamic threats. To
overcome these limitations, this study investigates the use of machine learning (ML) techniques to bolster data security
in public cloud environments.The proposed approach employs sophisticated ML algorithms to enhance security
measures, demonstrating notable performance improvements. The method achieved an accuracy of 97.6%, with a mean
absolute error (MAE) of 0.403 and a root mean square error (RMSE) of 0.203, reflecting its effectiveness and precision
in detecting and addressing security threats.This paper provides an in-depth analysis of the application of machine
learning for improving data security within cloud computing frameworks. It underscores the potential of ML to advance
current security practices and offers practical recommendations for the integration of these technologies to safeguard
data in public cloud settings.
Proactive Security Measures in Cloud Computing:
Enhancing Data Protection and Trust
Authors: Jain Prerna , Thakre Neha , Barman Shakshi , Yadav Mansi
Published: August 2024

Cloud computing has revolutionized the handling of data storage, management, and processing for
organizations, offering unparalleled scalability, flexibility, and cost-efficiency. With the increasing shift of businesses
and individuals to cloud-based solutions, the importance of robust security measures has become more pronounced.
However, the adoption of cloud computing also introduces unique security challenges, necessitating proactive strategies
to safeguard sensitive data and maintain trust in cloud services. The inherent characteristics of cloud environments—
shared resources, remote access, and multi-tenancy—heighten the risk of security breaches. Common threats in this
domain include data breaches, unauthorized access, and insider attacks. Traditional security measures often prove
inadequate in addressing these modern threats, underscoring the need for innovative and proactive security strategies.
This paper examines the proactive measures essential for enhancing security in cloud computing. It explores the
fundamental security challenges inherent in cloud environments, evaluates the effectiveness of current mitigation
strategies, and proposes advanced techniques to fortify cloud infrastructures against emerging threats. The proposed
method demonstrates an accuracy of 97.6%, a mean absolute error (MAE) of 0.403, and a root mean square error
(RMSE) of 0.203. By analyzing case studies and industry best practices, this research aims to provide a comprehensive
framework for organizations seeking to enhance their cloud security posture. The subsequent sections discuss the
evolution of cloud computing security, identify critical vulnerabilities, and present a detailed examination of proactive
measures such as encryption, identity and access management, continuous monitoring, and threat intelligence. The
objective is to contribute to the ongoing discourse on cloud security by offering practical insights and recommendations
for ensuring a secure cloud computing environment.
Comparative Study of Drying Shrinkage in Mortar with Different Cement-To-Fly Ash Ratios
Authors: Verma Parth , Tiwari Manish , Hoonka Vaibhav , Khare Arun Kumar , Mishra Gurusharan , Sirbaiya Bhupendra
Published: August 2024

The reduction in volume of concrete due to internal factors, unaffected by external forces, is termed as shrinkage. Drying shrinkage occurs after concrete hardens, often leading to cracks, which significantly impact the strength and durability of concrete by increasing its permeability and susceptibility to aggressive substances. Apart from chemical and autogenous shrinkage, drying shrinkage is particularly critical. This study examined how alternative cementitious materials like fly ash affect water absorption in concrete samples. Additionally, it explored the influence of factors such as water-cement ratio (w/c) and curing time on drying shrinkage in mortar specimens. The study also investigated the impact of cementitious materials on crack formation and propagation. Significant reductions in shrinkage were observed with optimized fly ash content, which also contributed to enhanced concrete strength.
Управління проєктами. Перспективи розвитку проєктного та нейроменеджменту, інформаційних технологій управління, технологій створення та використання об’єктів права інтелектуальної власності, трансфер технологій
Authors: Петренко В. О. , Молоканова В. М. , Дорожко Г. К.
Published: August 2024

У збірнику наукових праць наведені матеріали VI Міжнародної науково-практичної інтернет-конференції «Управління проєктами. Перспективи розвитку проєктного та нейроменеджменту, інформаційних технологій управління, технологій створення та використання об’єктів права інтелектуальної власності, трансферу технологій». Збірник наукових праць становить інтерес для наукових працівників, викладачів, фахівців з інтелектуальної власності та управління проєктами, а також студентів.
Metatheorizing Evolutionary Processes for Organisational Cybernetics
Authors: Osejo-Bucheli Camilo
Published: August 2024

This article revisits and expands the intersection of evolutionary processes and organizational cybernetics by developing a comprehensive metatheory. While traditional views within the Viable Systems Model (VSM) have often dismissed evolutionary paradigms as deterministic and incompatible with conscious organizational decision-making, this study challenges that notion by integrating key evolutionary concepts such as natural selection, autopoiesis, and symbiosis. Through theoretical synthesis and cybernetic modeling, the research illustrates how these dynamic processes underpin the evolution and adaptation of viable systems. The findings reveal that evolution in cybernetic systems is not merely a process of natural selection but also involves cooperative and symbiotic interactions that are crucial for organizational resilience and adaptability. This research offers a new perspective on evolutionary epistemology within organizational contexts, proposing that the future of organizational theory lies in understanding the complex interplay between competition, cooperation, and self-maintenance. The implications of this study are far-reaching, offering a foundation for future empirical research aimed at exploring the dynamics of organizational evolution and the development of more adaptable and sustainable systems.
INVESTIGATION OF THE EFFECT OF COMPRESSION RATIO AND DIFFERENT FUELS ON CO2 EMISSIONS
Authors: Doğan Hüseyin Emre , Demirci Abdurrahman , Kutlar Osman Akin
Published: August 2024

Air pollution caused by the exhaust gases of internal combustion engines threatens the future of these machines. CO2, which is normally non-polluting but causes global warming, has necessitated limiting the emission of this gas. Therefore, reducing CO2 production at its source is the most effective method. In particular, the use of fuels with a high H/C ratio, such as compressed natural gas (CNG), significantly reduces CO2 emission. In this study, the contribution of different mechanisms to CO2 reduction was examined by combining both thermal efficiency and fuel types. Experiments were conducted with gasoline and CNG fuels at different compression ratios and mixtures. When CNG was used instead of gasoline in stoichiometric mixture, CO2 emission was reduced by 23% at a brake mean effective pression (BMEP) of 5 bar. Approximately 8% less CO2 was produced when operating with a lean mixture (λ = 1.6) instead of a stoichiometric mixture for both fuels. In the experiments conducted with CNG, CO2 emission decreased by 1.5% when compression ratio was changed from 10.5 to 14. However, as the compression ratio increased, the volumetric efficiency decreased at constant BMEP. Therefore, the efficiency coefficient, which takes into account the effect of volumetric efficiency, was defined and it was observed that thermal efficiency could increase up to 7% by increasing the compression ratio from 10.5 to 14. Finally, when comparing CNG fuel with a high compression ratio (ε = 14) and ultra-lean mixture, and gasoline fuel with a low compression ratio (ε = 10.5) and stoichiometric mixture, it was observed that CO2 emission decreased by around 33%.
Briefing: How long-term monitoring of SuDS will inform next-generation guidance and modelling tools
Authors: De-Ville Simon , Wilson Fran , Stovin Virginia
Published: August 2024

Sustainable drainage systems (SuDS) are becoming more commonplace in urban environments due to the additional benefits they can provide alongside their core stormwater management function. In Mansfield, UK, Severn Trent Water is investing £76 million in retrofitting hundreds of SuDS to provide flood risk reduction to 90 000 people while simultaneously creating 5 ha of biodiversity-rich habitat. However, there is continued uncertainty about the long-term performance of these nature-based assets in comparison to traditional grey infrastructure. Through a new industrial–academic partnership, a long-term evaluation of SuDS performance across Mansfield will be used to inform the next generation of design guidance and modelling tools.
Android-based framework for condition assessment of existing RC hospital buildings
Authors: Khan Rashid A. , Mohammad Aslam F. , Haseeb Abdul , Hammad Muhammad , Siddiqui Muhammad Afnan , Lodi Sarosh H.
Published: August 2024

Rapid visual screening (RVS) is a practically viable tool implemented all over the world to rank structures based on their seismic vulnerability. Seismic assessment of hospital buildings is essential in seismic-prone regions to ensure their structural integrity and readiness to provide emergency care and medical treatment after significant seismic events. Therefore, in the current study, an approach is developed that is similar to the proven methodologies reported in the literature, for the seismic evaluation of structural and non-structural elements of hospital buildings in a metropolitan city like Karachi. Karachi is located in the southwest of Pakistan and is vulnerable to earthquake and tsunami hazards. To this end, an android-based RVS system has been developed for large-scale seismic risk mapping of hospital buildings. The proposed system acquires the physical status of the building features in real time and identifies the building performance obtained from the calculated seismic risk index. Moreover, three case study hospital buildings were employed and analysed through the proposed RVS system. Results illustrate the performance of case study hospital buildings at organisational, structural and non-structural levels based on seismic risk indices.
CONTEXT BETWEEN UNIVERSITY EXTENSION AND CONTINUING TEACHER TRAINING: CHALLENGES AND POSSIBILITIES
Authors: Brito Renato de Oliveira , Chesini Cláudia , Lucena José Ivaldo Araújo de , Rocha Rândala Maria de Morais Nogueira y
Published: August 2024

The challenges posed to the Brazilian university are directly linked to legislation and the understanding of the social function of higher education, explained through teaching, research, and extension. In its history, the university seeks to balance these three pillars, strengthening each other according to reality. Since 2018, with resolution nº 07/2018, of the National Education Council (CNE), university extension began to be assumed by universities with the same relevance as teaching and research, consolidating the balance between the pillars based on inseparability. This configuration has required a new approach, that is, the training of teachers for extension, through three dimensions: the production of consciousness – personal dimension, the production of knowledge – epistemological dimension, and the production of an integrated world – social commitment. Seeking to analyze the challenges and possibilities of continuing teacher training for university extension work, this study used qualitative methodology, through bibliographical research and the application of a questionnaire to collect data on the perception of teachers at a university in the Federal District, regarding the challenges and possibilities of university extension for continuing teacher training. The results highlighted the need for specific continuing education for teachers who consider university extension as a space-time commitment to the social transformation of the communities served.
A Challenging Extubation Caused by the Inability to Deflate the Cuff of an Endotracheal Tube
Authors: V Abraham , Ria Ria , M Singh
Published: August 2024

Background: Extubation is considered a critical event in general anesthesia. A smooth endotracheal intubation or an uneventful intra-operative period can still lead to a difficult extubation. This is a case report of an eventful and unanticipated difficult elective extubation in a post coronary artery bypass grafting patient. Observations: A knot was found on the pilot balloon tubing during extubation of the patient which made deflation of the endotracheal tube cuff almost impossible. After several minutes of troubleshooting, we were able to extubate the patient with stable hemodynamics without any evidence of sore throat. Significance: Rare cases and difficulties like these, challenge a healthcare provider to think beyond common knowledge and this serves as an example for other anaesthesiologists that how minute malfunctions in our common devices/instruments can lead to disastrous outcomes and hence vigilance is important.
Human Dorsal Root Ganglion spatial ATAC-seq protocol v1
Authors: Franco-Enzástiga Úrzula , Price Theodore
Published: August 2024

In this protocol, we describe how to perform spatial ATAC-seq on fresh-frozen human dorsal root ganglion.
USDA LTAR Common Experiment measurement: Infiltration and percolation v1
Authors: Saha Amartya
Published: August 2024

Infiltration refers to water entering the soil from precipitation, condensation, irrigation, and surface flow (runoff). It is typically used to quantify water arriving at the root zone of plants (example application: plant water availability). Percolation, while verbally synonymous with infiltration, is typically used to quantify water leaving the root zone for deeper soil horizons (example application: agrochemical leachate). Both processes occur when the soil is near saturation, relying on the continuity of the water column for the downward movement of water.
Brain Data Alchemy Project: Meta-Analysis of Re-Analyzed Public Transcriptional Profiling Data in the Gemma Database v1
Authors: Hagenauer Megan , Rhoads Cosette , Xiong Jinglin , Manh Nguyen Duy , Saffron Annaka , Kondur Amrita , Flandreau Elizabeth
Published: August 2024

Over the past two decades, transcriptional profiling has become an increasingly common tool for investigating the effects of diseases and experimental manipulations on the nervous system. Within transcriptional profiling experiments, microarray or sequencing technologies are used to measure the relative amount of RNA transcript for each of the thousands of genes expressed in a sample. The primary objective of these experiments is to identify genes that are differentially expressed in response to conditions of interest. However, transcriptional profiling experiments have traditionally been conducted with small sample sizes due to expense (e.g., n=3-10/group), resulting in low statistical power. Due to low power, these experiments are prone to capturing large technical artifacts and false positives rather than smaller biological effects of interest. To address this issue, we developed a 10-week summer research program (The Brain Data Alchemy Project) that guides participants through the process of performing a meta-analysis of differential expression effect sizes (Log2 Fold Change or Log2FC) extracted from publicly available transcriptional profiling datasets. To conduct our meta-analyses, we leverage the efforts of the Gemma project, which has curated, preprocessed, and re-analyzed over 19,000 publicly available datasets (https://gemma.msl.ubc.ca/home.html). Participants learn the fundamental principles of systematic review and R programming to conduct the dataset search, result extraction, and whole transcriptome meta-analysis. This protocol outlines the methods used during the first pilot year of the program in 2022.
Potensi Antivirus daripada Ekstrak Fermentasi Daun Nangka (Artocarpus heterophyllus) terhadap Virus Herpes Simpleks Jenis 1 (HSV-1)
Authors: Aziz Norhazniza , Md Nor Norefrina Shafinaz , S.P. Koh
Published: August 2024

Kewujudan virus rintang dadah dan mutasi virus baharu telah mendorong saintis untuk mengkaji terapi alternatif berasaskan produk semula jadi yang kaya dengan sumber bioaktif untuk merawat dan mengurangkan simptom jangkitan dengan lebih cekap. Dalam kajian ini, daun nangka telah difermentasi (JL) menggunakan kultur simbiotik gabungan bakteria asid asetik dan yis untuk menghasilkan ekstrak yang berpotensi sebagai agen antivirus terhadap virus herpes simpleks jenis 1 (HSV-1). Ujian ketoksikan ekstrak telah ditentukan melalui asai MTT (3-[4,5dimethylthiazol-2-yl]-2,5-diphenyl tetrazolium bromide) ke atas sel Vero bagi menentukan nilai CC50 dan hasil ujian ini mendapati kepekatan maksimum ekstrak yang tidak toksik untuk kajian antivirus ialah 15.17%. Kajian anti HSV-1 secara in-vitro, telah dinilai melalui tiga mod berbeza iaitu pasca rawatan, pra-rawatan dan virusid. Ekstrak JL didapati lebih berkesan sebagai antivirus secara pasca rawatan dan virusid dengan pendedahan terus ekstrak kepada HSV-1 selama 15 dan 30 minit telah merencat 100% aktiviti virus tersebut pada semua kepekatan ekstrak yang digunakan. Melalui analisis penjerapan dan pelakuran yang dijalankan, ekstrak JL dengan kepekatan 7.5% dan 15% didapati dapat menghalang virus memasuki sel. Hasil cerapan zarah virus menggunakan mikroskop transmisi elektron (TEM) mendapati interaksi JL secara terus pada zarah virus dapat memusnahkan sampul virus seterusnya merencat proses jangkitan. Hasil kajian ini menunjukkan ekstrak JL mempunyai potensi yang baik untuk dibangunkan sebagai agen anti-herpes yang berasaskan sumber semula jadi.
Kandungan Fitokimia, Aktiviti Antioksidan, Antihiperglisemia dan Antikegemukan Ekstrak Daun Annona muricata dengan Kekutuban Berbeza
Authors: Cheng Ai Nee , Hassan Noorhadi Najihah , Sofian-Seng Noor-Soffalina , Mediani Ahmed , Lim Seng Joe , Abdul Rahman Hafeedza
Published: August 2024

Annona muricata atau durian belanda adalah sejenis tumbuhan yang berada daripada famili Annonaceae, sering digunakan sebagai ubat tradisi untuk merawat pelbagai penyakit termasuk kanser, artritis dan malaria. Tumbuhan herba ini mengandungi sebatian bioaktif yang berpolar dan tidak berpolar. Penggunaan pelarut yang sesuai amat penting untuk mengekstrak sebatian bioaktif yang diinginkan dan juga mempengaruhi bioaktiviti ekstrak tersebut. Oleh itu, penyelidikan ini dijalankan untuk menentukan kesan pengekstrakan menggunakan pelarut berbeza polariti iaitu 70% metanol, etil asetat dan n-heksana terhadap aktiviti antioksidan, anti-lipase serta perencatan α-glukosidase ekstrak A. muricata. Selain itu, sebatian bioaktif yang menyumbang kepada bioaktiviti yang dikaji dikenal pasti menggunakan kromatografi cecair-spektrometer jisim (LC-MS). Dalam kajian ini, penentuan jumlah kandungan fenolik dalam ekstrak daun A. muricata dilakukan. Aktiviti antioksidan ekstrak daun A. muricata dinilai dengan ujian penyingkiran radikal bebas 2,2-difenil-2-pikrilhidrazil (DPPH) manakala aktiviti antihiperglisemik dan aktiviti anti-lipase dikaji dengan ujian perencatan α-glukosidase dan ujian perencatan lipase pankreas. Sampel yang diekstrak dengan etil asetat menunjukkan nilai IC50 terendah secara signifikan (p<0.05) pada aktiviti antioksidan (35.31 ± 2.74 µg/mL), aktiviti anti-hiperglisemik (32.11 ± 4.62 µg/mL) serta anti-lipase (215.92 ± 13.25 µg/mL) berbanding dengan ekstrak 70% metanol dan n-heksana. Sampel tersebut juga menunjukkan kandungan fenolik yang tinggi iaitu sebanyak 46.40 ± 1.95 mg GAE/g ekstrak. Korelasi negatif antara TPC dengan nilai IC50 DPPH dan anti-hiperglisemik menunjukkan sebatian fenolik bertanggungjawab terhadap aktiviti antioksidan dan anti-hiperglisemik. Sebanyak 13 sebatian bioaktif termasuk kaemferol, kuersetin-3-O-glikosida dan kuersetin telah dikenal pasti melalui analisis LC-MS. Berdasarkan kepada kajian, etil asetat adalah pelarut yang paling baik untuk melarutkan sebatian aktif pada daun A. muricata berbanding dengan 70% metanol dan n-heksana. Hasil kajian juga menunjukkan keupayaan daun A. muricata untuk dibangunkan sebagai makanan fungsian atau ubat-ubatan bagi mencegah atau mengubati diabetes dan mengawal obesiti.
Knowledge, Attitude, Practice and Associated Factors Regarding Vision Screening among Preschool Teachers in Malaysia
Authors:   Faculty of Health Sciences, Centre for Community Health Studies (ReaCH), University Kebangsaan Malaysia, Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia.
Published: August 2024

Preschool vision screening is carried out by optometrist in Malaysia. However, inadequate manpower limits the ability of this screening to be conducted nationwide. Teachers’ involvement in the screening team could be beneficial to overcome this issue. Therefore, it is important to understand teachers’ knowledge, attitude, and practice (KAP) on vision screening. This study aimed to assess preschool teachers’ level of KAP and identify the contributing factors. A cross-sectional study was conducted among public and private preschool teachers in Malaysia. A self-administered online questionnaire was used as the data collection tool. The contributing factors affecting the KAP level were determined using binary logistic regression analysis. The majority of the preschool teachers were in the high-level category for knowledge (74.1%), attitude (75.0%), and practice (81.2%). Factors contributing to the level of knowledge were teachers from private preschools and serving at preschools conducting vision screening. Being female, teachers with a non-education field of study and without a history of eye problems/diseases were associated with attitude level. Meanwhile, factors contributing to the practice level were age, Malay teachers, involvement in vision screening training, and serving at preschools conducting vision screening. Training and exposure to vision screening can increase teachers’ KAP levels regarding vision screening.
İlkokul 4. Sınıf Fen Bilimleri Öğretim Programı ‘‘Basit Elektrik Devreleri’’ Ünitesinin Tyler’ın Hedefe Dayalı Program Değerlendirme Modeline Göre İncelenmesi
Authors: Yıldırım Nazife Tuğba , İflazoğlu Saban Ayten
Published: August 2024

Bu çalışma İlkokul 4. Sınıf Fen Bilimleri Öğretim Programında yer alan Basit Elektrik Devreleri ünitesinin Tyler’ın Hedefe Dayalı Program Değerlendirme Modeline göre değerlendirilmesidir. Araştırmada iç içe karma yöntem kullanılmış. Araştırmanın çalışma grubu, 2021-2022 eğitim öğretim yılında Gaziantep ili Şahinbey ilçesinde bulunan bir ilkokulun 4. sınıfında öğrenim gören 238 öğrenci ve Şahinbey ilçesinde bulunan 7 farklı ilkokulda görevli, dördüncü sınıfı okutan 41 sınıf öğretmeninden oluşmaktadır. Araştırma tüm aşamaları ile birlikte toplamda 6 haftalık bir süreçte tamamlanmıştır. Veri toplama aracı olarak araştırmacılar tarafından geliştirilen başarı testi, öğretmen anketi, gözlem formu ve yarı yapılandırılmış görüşme formu kullanılmıştır. Elde edilen nicel verilerin analizinde betimsel istatistikler, bağımlı gruplar t-testi, Cohen’s d testi; nitel verilerin analizi için ise içerik analizi kullanılmıştır. Araştırmada, öğrencilerin ünite ile ilgili olarak yüksek hazır bulunuşluk düzeyine sahip oldukları, ön-test ve son-test puanları arasında son-test puanları lehine anlamlı bir farkın oluştuğu; sonuç olarak da öğrencilerin ünitedeki kazanımların tümüne ulaştıkları sonucuna ulaşılmıştır. Benzer şekilde öğretmenlere uygulanan anket sonucunda da, öğretmenlerin ünitenin kazanımları ve bu kazanımların programın diğer ögeleriyle ilgili olumlu bir bakış açısına sahip oldukları tespit edilmişse de ders gözlemleri esnasında öğretmen ve öğrencilerin ünite ile ilgili bazı kavram yanılgılarına sahip oldukları belirlenmiştir.
Öğretim Elemanlarının Bakış Açısından Yükseköğretimde Sınıf Yönetimi
Authors: Özşahin Büyükaşık Sinem , Balcı Karaboğa Ayşe
Published: August 2024

Bu araştırmanın amacı, yükseköğretimde sınıf yönetiminin kendine has özelliklerini öğretim elemanlarının görüşlerinden hareketle ortaya koymaktır. Bu kapsamda nitel araştırma desenlerinden fenomenolojik desen kullanılmış ve görüşme tekniğiyle öğretim elemanlarının görüşleri alınmıştır. Çalışma grubunu; farklı bölümlerde görev yapan Mersin Üniversitesi Eğitim Fakültesinden 9, Fen Edebiyat Fakültesinden 11 olmak üzere toplam 20 öğretim elemanı oluşturmaktadır. Kavramsal çeşitliliğe ve farklı bakış açılarına ulaşabilmek amacıyla maksimum çeşitlilik örneklem tekniği kullanılmıştır. Araştırmanın verileri betimsel analiz basamaklarına göre değerlendirilmiştir. Çalışmanın bulgularının değerlendirilmesi sonucunda yükseköğretimde sınıf yönetiminde “öğrenci davranışlarının yönetimi”, “öğretimin yönetimi”, “öğrenci sayıları/sınıf büyüklüğü”, “mekân”, “iletişim”, “teknoloji” ve “motivasyon” olmak üzere 7 boyut ortaya konmuştur. Yükseköğretimde sınıf yönetiminin boyutlarının farklı üniversitelerde ve bölümlerde görev yapan öğretim elemanlarının ve farklı yaş gruplarında olan ve farklı üniversitelerde/bölümlerde öğrenim gören öğrencilerin katılımlarıyla daha geniş bir örnekleme ulaşılarak çalışılması önerilmektedir.
The Democratization of Systematic Biology
Authors: Kearney Maureen , Dittmar Katharina
Published: August 2024

Science, like other sectors of society, is currently in a period of rapid social and cultural change. Demands for the decolonization and democratization of research culture and scientific data are prevalent. Systematic biology, as the research community that focuses on the existentially important issue of understanding global biodiversity, and as the standard-bearer for a field deeply rooted in colonialist approaches, has a unique opportunity to develop and model a meaningful and actionable vision for systemic change. Because systematics research requires sampling and analyzing planetary biodiversity, it operates within a global arena in which undoing exclusionary norms and practices, and reimagining a new kind of science that builds knowledge collectively, is both possible and potentially hugely impactful. Because of its history, the discipline has the potential to become a powerful model of intentional transformation. Professional systematists work and conduct research across natural history museums, academic institutions, federal agencies, national laboratories, international organizations, and the private sector and they serve as leaders throughout the disciplinary ecosystem; as a result, they are well-positioned to shape cultural transformation. We highlight just one example of a change lever (peer review of proposals) to illustrate this. Beneficial outcomes of such a new era of systematics will be extensive for continued research advances in biodiversity and phylogenetics, and for critical challenges that lie at the science-society-policy intersection.
Tolerability of the first inhaled mannitol dose in children with cystic fibrosis
Authors: Shadrina V. V. , Zhekaite E. K. , Voronkova A. Yu. , Sherman V. D. , Kondakova Yu. A. , Pinegina Yu. S. , Poloyko A. A. , Furman E. G. , Kondratyeva E. I.
Published: August 2024

Mannitol for inhalation is recommended for the treatment of cystic fibrosis in children over 6 years of age and adults. Because of the risk of bronchospasm, a challenge test to assess the drug tolerability should be performed prior to prescribing inhalation mannitol. Aim. Tо evaluate the tolerability of the first dose of inhaled mannitol in children with cystic fibrosis. Methods. The mannitol challenge test (according to the instructions for use of the Bronchitol (inhaled mannitol), Pharmaxis Ltd, Australia) was assessed in 81 children aged 6 to 18 years (11.6 ± 3.2 years). The patients were observed in the centers of the Novosibirsk region, the Moscow region, and the Perm region. The patient’s general state, forced expiratory volume in the first second (FEV1), and SpO2 were monitored. Results. Baseline FEV1 data in patients ranged from 30 % to 146 % (87.8 ± 25.7%), and SpO2 was 94 – 99% (97.7 ± 1.3%). 73 (90.1%) patients passed the test. In 8 (9.9%) patients, the following symptoms were observed: bronchospasm (6), laryngospasm (1), and vomiting (1). Bronchial obstruction was treated by inhalation of a bronchodilator, and the children were under observation until the restoration of FEV1. In patients who passed the test, FEV1 ranged from 33 to 149 % (85.4 ± 24.5%), and SpO2 spanned from 95 to 99% (96.7 ± 1.7%). The children who did not pass the test were monitored. One patient passed the test later when targeted therapy was added. Two children did not tolerate other mucolytic drugs (one child – NaCl solution in various dilutions, and the second patient suffering from asthma – dornase alfa). During follow-up, one patient was diagnosed with allergic bronchopulmonary aspergillosis at 12 years of age and with asthma at 13 years of age, which may have influenced the decrease in mannitol tolerability through formation of bronchial hyperreactivity. Thus, true adverse drug reaction in the form of bronchospasm occurred in three children out of 81 (3.7%). Conclusion. 90.1% of patients passed the inhalation mannitol challenge test, and 9.9% of patients did not pass the test. Analysis of adverse drug reactions revealed that only 3.7% of patients experienced true adverse reactions in the form of bronchospasm. During the test, patients were taught the correct technique for inhaling the drug. All the supplies to relieve bronchospasm should be readily available during the test.
Lung lesions in lymphoproliferative diseases
Authors: Gainitdinova V. V. , Avdeev S. N.
Published: August 2024

Primary lymphomas are classified according to the WHO general classification system. Despite the fact that more than half of patients with nodular lymphomas have lung lesions, primary pulmonary lymphomas account for less than 0.5% of all primary lung neoplasms. In addition, the most common primary lung lymphoma, non-Hodgkin’s B-cell marginal zone lymphoma (MALT lymphoma), accounts for less than 10% of extranodal lymphomas. Hodgkin’s lymphomas (LH) are only rarely considered primary lung lymphomas, even if the lungs are the main affected organ. Moreover, in most cases of primary pulmonary MALT lymphoma, in-depth examination reveals other extranodal sites (for example, stomach, colon, thyroid gland, bone marrow) that can be identified as sites of subclinical clonal lymphoid proliferation. Secondary lung damage in lymphomas is found in half of the cases and is more common than primary pulmonary lymphoma. However, it is difficult to morphologically determine the difference between primary pulmonary lymphoma and secondary lung damage in malignant lymphoproliferative diseases (LPDs). The aim was to present an overview of the clinical and diagnostic features of primary and secondary lung lesions in malignant lymphoproliferative diseases. Conclusion. Lung lesions in lymphoproliferative diseases can be primary and secondary. Primary lung and pleural lesions in LPDs are rare, while lymphomas that secondary lung lesions are identified in 20% of the cases during autopsy. In most patients, the diagnosis is based on the results of light microscopy, immunohistochemical and molecular assays.
Intellectual Property Protection on E-Commerce Platforms: New Legal Initiatives
Authors: Xue Hong
Published: August 2024

E-commerce platforms that provide the virtual marketplace play a crucial role in digital trade. They can not only cultivate new brands in trade but also provide effective protection for intellectual property rights. Legal reforms are happening in multiple dimensions to optimize platform intellectual property measures. The Chinese law requires that platform operators proactively engage with intellectual property right holders in the development of platform rules and cooperate with all the stakeholders in enforcement of these rules. EU laws, on the other hand, delegate very large platforms to affirmatively decide whether right holders’ notices against on-platform operators’ infringing activities are sufficiently substantiated and whether to act upon them. The notice-and-takedown model that had been integrated into the platform liability system is shifting gradually to a progressive and comprehensive platform governance mechanism that may keep appropriate balance among different stakeholder groups. Platforms are legally required to conduct due process to protect the legitimate interests of both intellectual property right holders and businesses on the platform. The legal reforms strengthen platform’s legal obligations and intensify legal review of platform governance. Platform alternative dispute resolution (ADR) mechanisms that provide on-platform operators an appeal process against the platforms’ measures taken against them also provide an important safeguard to the legitimate rights and interests of on-platform operators.
Evolución de la literatura sobre estructura de capital
Authors: Agudelo Aguirre Alberto Antonio , Toro Echeverri Sergio
Published: August 2024

El estudio de la estructura financiera de una compañía es valioso para la generación de modelos que busquen la conformación de una estructura de capital adecuada que resulte en el uso eficiente de recursos y en una relación equilibrada entre el nivel de endeudamiento, el riesgo financiero y el costo de capital. Este estudio identifica las publicaciones más influyentes en la evolución del campo de estructura de capital, las publicaciones más citadas, focos del conocimiento y sus temáticas de disgregación. Adicionalmente, proporcionar una estructura categorizando las publicaciones de acuerdo con su contribución seminal, estructural o reciente. La metodología estuvo compuesta por una búsqueda bibliográfica en las bases de datos académicas Scopus y Web of Science (WoS), el análisis estructural de la red bilibliográfica mediante el software Tree of Science (ToS) y el análisis de clústeres con el software GephiÒ. Los resultados muestran que si bien los postulados de la teoría de Modigliani y Miller representan la base de estudio fundamental, no existe una hipótesis universal válida para la formulación de una estructura de capital. Por otro lado, se identificó la temática riesgo corporativo como la de mayor debate científico en las últimas décadas, con el mayor y más creciente número de publicaciones y análisis de diversos tipos, con segundo lugar de importancia para los determinantes de la estructura de capital. El desarrollo del estudio permitió conocer que las tendencias investigativas actuales se orientan hacia el análisis del riesgo respecto a la estructura de capital, considerado tanto desde la perspectiva de la incidencia de aspectos macroeconómicos, geopolíticos y del entorno en general sobre la estructura de capital, como el efecto que tiene la estructura de capital en el riesgo financiero y de liquidez de la compañía.