bluuebunny/crossref_metadata_2025 huggingface dataset:
Strategic Decisions in Corporate Travel: Optimization Through Decision Trees
Authors: Zarate-Carbajal Jose-Mario , Ruiz-Cruz Riemann , Sánchez-Torres Juan Diego
Published: November 2024

Global corporations frequently grapple with a dilemma between fulfilling business needs and adhering to travel policies to mitigate excessive fare expenditures. This research examines the multifaceted nature of business travel, delving into its key characteristics and the inherent complexities faced by management in formulating effective policies. An optimal travel policy must both be practical to implement and contribute to budget optimization. The specific requirements of each company necessitate tailored policies; for instance, a manufacturing company with scheduled trips demands a distinct policy, unlike a consulting firm with unplanned travel. This study proposes a modified regression decision tree machine learning algorithm to incorporate the unique features of corporate travel policies. Our algorithm is designed to self-adjust based on the specific data of each individual company. The authors implement the proposed approach using travel data from a real-world company and conduct simulations in various scenarios, comparing the results with the industry standard. This research offers a machine-learning-based approach to determining the optimal advance booking policy for corporate travel.
Sliding Mode Control of Uncertain Switched Systems via Length-Limited Coding Dynamic Quantization
Authors: Xu Qinqi , Zhao Haijuan
Published: November 2024

This paper designs an online adjustment strategy for dynamic quantizer parameters and investigates the sliding mode control (SMC) problem for uncertain switched systems under a limited network communication bandwidth. Due to the limitation of the coding length in practical transmission, coding errors can significantly impact the system’s ideal performance. To address these issues, a dynamic quantizer is introduced to efficiently encode the system state while minimizing quantization error under the constraint of the finite code length. Additionally, a coding and decoding scheme based on dynamic quantization and a suitable sliding mode controller are designed to obtain a closed-loop switched system. Using Lyapunov functions and the average dwell time method, sufficient conditions are derived to guarantee the reachability of the sliding surface and the exponential ultimate bound (EUB) in the mean square for the closed-loop switched system, even in the presence of coding errors and data loss. The theoretical results are validated through numerical simulations, which demonstrate the effectiveness of the proposed approach.
Reliability Growth Method for Electromechanical Products Based on Organizational Reliability Capability Evaluation and Decision-Making
Authors: Mu Zongyi , Li Jian , Zhang Xiaogang , Zhang Genbao , Li Jinyuan , Wei Hao
Published: November 2024

The reliability growth of electromechanical products is a continuous process of addressing reliability defects, which is very important for manufacturing enterprises. At present, research on the reliability growth of electromechanical products mostly focuses on the reliability defects of the products themselves, ignoring the fact that manufacturing enterprises are the executors of product reliability related work. Improving the organizational reliability capability of manufacturing enterprises can enhance the reliability of electromechanical products. In order to understand the current situation of organizational reliability capability (ORC) in electromechanical product manufacturing enterprises and make improvements, this paper establishes an ORC evaluation indicator framework for electromechanical product manufacturing enterprises and evaluates it using the grey evaluation method. Firstly, an evaluation indicator framework for ORC is established based on enterprise research. Secondly, the ORC of electromechanical product manufacturing enterprises is evaluated by combining the three-parameter interval grey number and projection index function. Then, the evaluation results are analyzed from multiple perspectives to understand the current situation and shortcomings of ORC and guide its improvement. Finally, the evaluation indicator framework and method are explained through practical application in CNC machine tool manufacturing enterprises, and the effectiveness of the framework and method is demonstrated through the MTBF growth of CNC machine tools.
An Anonymous and Efficient Authentication Scheme with Conditional Privacy Preservation in Internet of Vehicles Networks
Authors: Kim Chaeeon , Kwon DeokKyu , Son Seunghwan , Yu Sungjin , Park Youngho
Published: November 2024

The Internet of Vehicles (IoV) is an emerging technology that enables vehicles to communicate with their surroundings, provide convenient services, and enhance transportation systems. However, IoV networks can be vulnerable to security attacks because vehicles communicate with other IoV components through an open wireless channel. The recent related work suggested a two-factor-based lightweight authentication scheme for IoV networks. Unfortunately, we prove that the related work cannot prevent various security attacks, such as insider and ephemeral secret leakage (ESL) attacks, and fails to ensure perfect forward secrecy. To address these security weaknesses, we propose an anonymous and efficient authentication scheme with conditional privacy-preserving capabilities in IoV networks. The proposed scheme can ensure robustness against various security attacks and provide essential security features. The proposed scheme ensures conditional privacy to revoke malicious behavior in IoV networks. Moreover, our scheme uses only one-way hash functions and XOR operations, which are low-cost cryptographic operations suitable for IoV. We also prove the security of our scheme using the “Burrows–Abadi–Needham (BAN) logic”, “Real-or-Random (ROR) model”, and “Automated Validation of Internet Security Protocols and Applications (AVISPA) simulation tool”. We evaluate and compare the performance and security features of the proposed scheme with existing methods. Consequently, our scheme provides improved security and efficiency and is suitable for practical IoV networks.
Development and Prevention of Biofilm on Cochlear Implants: A Systematic Review
Authors: Tsikopoulos Alexios , Tsikopoulos Konstantinos , Sidiropoulos Konstantinos , Meroni Gabriele , Triaridis Stefanos , Drago Lorenzo , Papaioannidou Paraskevi
Published: November 2024

Background and Objectives: Biofilm formation on cochlear implants (CIs) poses a major problem for surgeons, leading to a high incidence of explantation and revision surgery. Therefore, developing appropriate and cost-effective biofilm detection and prevention techniques is of the essence. In this systematic review, we sought to investigate the development of biofilm formation on CIs. We also elaborated on experimental preventative biofilm measures. Materials and Methods: We conducted a systematic search of both in vitro and in vivo literature published in PubMed, Scopus, and ScienceDirect, until 15 June 2024, for published studies evaluating the biofilm formation and strategies for inhibiting biofilm formation on CIs. Depending on the type of the included study, we assessed quality with the modified Consolidated Standards of Reporting Trials tool, the Joanna Briggs Institute Case Reports Critical Appraisal Tool, a modified Delphi technique, and the ROBINS-I tool. We synthesized the available information on biofilm formation on CIs and the infection prevention capacity of the included antibiofilm agents. Results: A total of 26 studies were included in this systematic review. Biofilms in CIs are usually localized in their recesses such as their removable magnet pocket as opposed to their smooth surfaces. S. aureus and P. aeruginosa are the most commonly isolated microorganisms, and they tend to be strong biofilm producers. The optimal treatment strategy for a biofilm-infected CI is explantation. Most of the examined biofilm prevention methods in CIs present sufficient antibiofilm activity. Conclusions: Biofilm formation in CIs is considered one of the most dreadful complications. There have been no specific guidelines for the treatment of those cases, with removal and/or replacement of the CI being the treatment of choice. Various experimental prevention methods provide promising antibiofilm activity both in vivo and in vitro.
Inflammatory and Hemolytic Responses of Microaxial Flow Pump Temporary Ventricular Assist Devices via Axillary Access in Cardiogenic Shock
Authors: Schmack Leonie , Ali-Hasan-Al-Saegh Sadeq , Weymann Alexander , Pizanis Nikolaus , Akhyari Payam , Zubarevich Alina , Hanke Jasmin Sarah , Popov Aron-Frederik , Ruhparwar Arjang , Rassaf Tienush , Kamler Markus , Luedike Peter , Schmack Bastian
Published: November 2024

Background and Objectives: The use of temporary left ventricular assist devices (tLVADs) for patients suffering from cardiogenic shock (CS) is becoming more common. This study examines the indications and outcomes of microaxial flow pumps (Impella®, Abiomed Inc., Danvers, MA, USA) when cannulated through the axillary artery in patients with severe CS, with a particular focus on acute phase reactions and hemolytic responses. Materials and Methods: This single-center, retrospective cohort involved patients who received microaxial Impella implantation via the axillary artery from 2020 to 2022 (n = 47). Results: Among the patients, 66% (N = 31 cases) were treated with the Impella 5.5, 25.5% (N = 12 cases) with the Impella 5.0, and 8.5% (N = 4 cases) with the Impella CP. Additionally, 28% were managed using the ECMELLA concept. The mean length of time for Impella support was 8 days. The overall 30-day survival rate was 78%, with no significant differences observed between the ECMELLA group and the various Impella types. At 30 days post-therapy, 47% of survivors no longer required mechanical support, while 26% were upgraded to a durable LVAD. Interleukin-6 (IL-6) levels were significantly lower in patients receiving Impella 5.5 (n = 17 vs. 12) immediately following implantation (p = 0.03) compared with those with smaller devices. Haptoglobin levels were significantly higher in the Impella 5.5 group (n = 17 vs. 11, p = 0.02), with overall lower rates of hemolysis (45.1%, p < 0.01). Conclusions: The mortality rate in critical CS appears reduced with axillary artery implantation of Impella devices relative to existing literature. A full-flow microaxial pump (Impella 5.5) seems advantageous regarding systemic inflammatory response syndrome (SIRS) and acute hemolysis, indicated by lower IL-6 and higher haptoglobin levels, compared with smaller Impella devices. A tailored escalation/de-escalation concept using axillary access for different mAFP types appears feasible and safe.
System Dynamics Modeling of Scale Formation in Membrane Distillation Systems for Seawater and RO Brine Treatment
Authors: Shin Yonghyun , Koo Jaewuk , Lee Sangho
Published: November 2024

To overcome the limitations of traditional Reverse Osmosis (RO) desalination, Membrane Distillation (MD) has gained attention as an effective solution for improving the treatment of seawater and RO brine. Despite its potential, the formation of inorganic scales, particularly calcium sulfate (CaSO4), continues to pose a major challenge. This research aims to explore the scaling mechanisms in MD systems through a combination of experimental analysis and dynamic modeling. Using real seawater and RO brine as feed sources, the scaling behavior was examined under various operational conditions, such as temperature and feed concentration. Optical Coherence Tomography (OCT) was utilized to monitor the real-time development of fouling layers, offering valuable insights into surface crystal formation processes. A System Dynamics Model (SDM) was created based on the experimental data to predict flux decline trends with precision. The model correlated well with experimental observations, highlighting key factors that drive scaling severity. This integrated approach deepens our understanding of scaling dynamics and provides actionable strategies to mitigate fouling in MD systems, thereby enhancing the efficiency and stability of MD desalination operations. Ultimately, this study underscores the potential of combining OCT with system dynamics modeling as a powerful approach for visualizing and validating scaling processes, offering a practical framework for optimizing MD performance and contributing to more sustainable desalination practices.
Laser Powder Bed Fusion of Pure Titanium: Optimization of Processing Parameters by Means of Efficient Volumetric Energy Density Approach
Authors: Badini Claudio F. , Santero Tommaso , Rosito Michele , Padovano Elisa
Published: November 2024

This paper focuses on optimizing the process parameters for manufacturing commercially pure titanium grade 2 using Laser Powder Bed Fusion (L-PBF) technology. The most common approach involves trial-and-error builds with varying parameter combinations, followed by characterizing the bulk samples for defects and the microstructure. This method, typically based on Volumetric Energy Density (VED), is time-consuming and overlooks key powder properties. An alternative approach involves the use of efficient Volumetric Energy Density (VEDeff), which represents the energy density effectively available for the L-PBF process, considering both the process parameters and powder properties such as absorptivity and thermal diffusivity. In this study, VEDeff was applied and compared to a work window defined by thermodynamic data, with limits corresponding to the energy needed for titanium melting and evaporation. Forty-two tests were performed with different combinations of laser powers and scanning speeds; the samples were then characterized in terms of porosity, microstructure, and hardness. The findings showed no correlation between VED and the work window while VEDeff aligned with the work window, although the highest relative densities (>99%) and hardness values were achieved in a narrower range. Despite this, the VEDeff approach proved to be a useful starting point for optimizing the process parameters.
Effects of Ti Addition on Microstructure, Mechanical Properties and Corrosion Resistance of the Cu-Zn-Ni Alloy
Authors: Sun Xinglong , Wang Yulian , Jie Jinchuan , Li Tingju , Yuan Zhigang , Cui Haitao , Liu Jinsong
Published: November 2024

The effects of Ti addition on the microstructure, mechanical properties and corrosion resistance of the Cu-30Zn-6Ni-1.5Ti (wt.%) alloy were investigated in the present study. Microstructure analysis confirms that the Ni3Ti and NiTi phases are formed in the Cu-Zn-Ni-Ti alloy. Most of the Ni3Ti particles dissolve into the matrix, whereas NiTi particles remained after the solution treatment. Moreover, nano-sized Ni3Ti and Cu2NiZn phases are precipitated from the matrix during the aging process. The yield strength improvement of the studied alloy is attributed to the Orowan strengthening (accounting for 42.5% of the total yield strength), then the grain boundary strengthening (31.1%), the dislocation strengthening (16.9%), the twin boundary strengthening (5.0%) and the solid solution strengthening (0.5%). After cold rolling with 90% deformation and aging at 440 °C for 1 h, the designed alloy has a hardness of 327.1 HV, a yield strength of 1192 MPa, an ultimate tensile strength of 1297 MPa, an elongation of 1.8%, an electrical conductivity of 11.2% IACS and a corrosion rate of 2.8 μm/month in 3.5% NaCl solution.
Laser Fabrication and Performance of Flexible Pressure Sensors with Ridge-Mimicking Spatially Ordered Microstructures
Authors: Wu Linjing , Gao Chao , Wang Jincheng , Zhang Chen , Ke Yuzhi
Published: November 2024

The proliferation of flexible pressure sensors has generated new demands for high-sensitivity and low-cost sensors. Here, we propose an elegant strategy to address this challenge by taking a ridge-mimicking, gradient-varying, spatially ordered microstructure as the sensing layer, with laser processing and interdigitated electrodes as the upper and lower electrode layers. Simultaneously, the entire structure is encapsulated with polyimide (PI) tape for protection, and the fabrication process is relatively feasible, facilitating easy scaling. The presented results show that the flexible pressure sensor exhibits a sensitivity of 1.65 kPa−1 across a pressure range of 0 to 1100 kPa. Furthermore, the sensor displays low hysteresis, as well as rapid response and recovery times of 62 ms and 83 ms, respectively. Finally, we demonstrate the application potential of the sensor for monitoring joint movements, especially for detecting pressure and direction in finger joints. This technology shows great potential for applications in smart robotics, wearable devices, health monitoring, and other emerging technologies.
Multilocus Sequence Typing and Antimicrobial Susceptibility of Listeria monocytogenes Isolated from Foods Surveyed in Kosovo
Authors: Jashari Besart , Stessl Beatrix , Félix Benjamin , Cana Armend , Bisha Bledar , Jankuloski Dean , Blagoevska Katerina , Kayode Adeoye J.
Published: November 2024

In the absence of data on the reporting of L. monocytogenes resistance to antibiotics, we sought to determine which clonal complexes (CCs)/sequence types (STs) circulate in the food chain in Kosovo and to determine their antibiogram profiles to a panel of 18 antibiotics. From a total of 114 isolates, 21 different typical STs were identified by multilocus sequence typing (MLST). Each isolate derived from the food categories was subjected to tests to verify its susceptibility to the selected antibiotics according to the designed Sensititre GPN3F panel. Among the different STs that were identified, CC9-ST9 was more abundant in meat products (38.75%) while CC29-ST29 was more abundant (24.0%) in dairy products. Moreover, these isolates showed marked resistance against levofloxacin (22.8%), gentamicin and rifampicin (17.5%), quinupristin/dalfopristin (14.9%), erythromycin (11.4%), penicillin (7.89%), tetracycline (1.75%), and streptomycin (0.88%). A total of 27 multiple antibiotic resistance (MAR) phenotypes were observed amongst the isolates, which ranged from 3 to 12. The ARI of the food category including meat and meat products (MMP, 0.22) and fish meat products (FMP, 0.26) were >0.2, the permissible Krumperman threshold. The number of strains with MAR values >0.2 was 34, (29.8%). The identification of typical multidrug-resistant STs among L. monocytogenes isolates in Kosovo constitutes a potential threat to food safety and public health, which requires a continuous and expanded surveillance system to prevent the further spread of antimicrobial resistant (AMR) isolates.
Macrogenomic Analysis Reveals Soil Microbial Diversity in Different Regions of the Antarctic Peninsula
Authors: Qu Jiangyong , Lu Xiaofei , Liu Tianyi , Qu Ying , Xing Zhikai , Wang Shuang , Jing Siluo , Zheng Li , Wang Lijun , Wang Xumin
Published: November 2024

(1) Background: The unique geographical and climatic conditions of the Antarctic Peninsula contribute to distinct regional ecosystems. Microorganisms are crucial for sustaining the local ecological equilibrium. However, the variability in soil microbial community diversity across different regions of the Antarctic Peninsula remains underexplored. (2) Methods: We utilized metagenome sequencing to investigate the composition and functionality of soil microbial communities in four locations: Devil Island, King George Island, Marambio Station, and Seymour Island. (3) Results: In the KGI region, we observed increased abundance of bacteria linked to plant growth promotion and the degradation of pollutants, including PAHs. Conversely, Marambio Station exhibited a significant reduction in bacterial abundance associated with iron and sulfur oxidation/reduction. Notably, we identified 94 antibiotic resistance genes (ARGs) across 15 classes of antibiotics in Antarctic soils, with those related to aminoglycosides, β-lactamase, ribosomal RNA methyltransferase, antibiotic efflux, gene regulatory resistance, and ABC transporters showing a marked influence from anthropogenic activities. (4) Conclusions: This study carries substantial implications for the sustainable use, advancement, and conservation of microbial resources in Antarctic soils.
Concomitant Potentially Contagious Factors Detected in Poland and Regarding Acanthamoeba Strains, Etiological Agents of Keratitis in Humans
Authors: Chomicz Lidia , Szaflik Jacek P. , Kuligowska Agnieszka , Conn David Bruce , Baltaza Wanda , Szostakowska Beata , Zawadzki Paweł J. , Dybicz Monika , Machalińska Anna , Perkowski Konrad , Bajer Anna , Szaflik Jerzy
Published: November 2024

Background: Diseases in humans caused by amphizoic amoebae that can result in visual impairment and even blindness, have recently been identified more frequently worldwide. Etiologically complex incidents of keratitis, including those connected with Acanthamoeba strains detected in Poland, were evaluated in this study. Methods: Corneal samples from cases resistant to antimicrobial therapy assessed for epidemiological, microbiological and parasitological aspects were investigated by phase-contrast microscope, slit lamp and by confocal microscopy. In vitro techniques were applied for detection of bacteria and fungi, and corneal isolates cultured under axenic condition using BSC medium—for detection of Acanthamoeba spp.; molecular techniques were applied for amoeba species identification. Results: Most etiologically complicated keratitis cases, detected in ~84% of incidents, was due to exposure of contact lenses to tap water or pool water; trophozoites and cysts of Acanthamoeba, concomitant bacteriae, e.g., Pseudomonas aeruginosa, fungi and microfilariae were identified in contact lens users. Conclusions: In samples from contact lens wearers where microbial keratitis is identified along with some connection with the patient’s exposure to contaminated water environments, a risk of Acanthamoeba spp. infections should be considered. Understanding the complicated relationship between Acanthamoeba spp., co-occurring pathogens including associated endosymbionts is needed. In vivo confocal microscopy and in vitro cultivation were necessary to identify potentially contagious concomitant factors affecting the complex course of the keratitis.
Mercury and Arctic Char Gill Microbiota Correlation in Canadian Arctic Communities
Authors: Amill Flora , Couture Patrice , Derome Nicolas
Published: November 2024

Arctic char is a top predator in Arctic waters and is threatened by mercury pollution in the context of changing climate. Gill microbiota is directly exposed to environmental xenobiotics and play a central role in immunity and fitness. Surprisingly, there is a lack of literature studying the effect of mercury on gill microbiota. To fill this knowledge gap, our primary goal was to measure to what extent gill exposure to mercury may alter gill microbiota activity in Arctic char. Specifically, we calculated the correlation between the taxonomic distribution of gill-associated bacterial symbiont activity and total mercury concentration in livers and muscles in wild populations of Arctic char in the Canadian Arctic. Our results showed that total mercury concentrations in tissues were higher in Ekaluktutiak (Nunavut) than in the other sites in Nunavik. Proteobacteria was the main phylum correlated to mercury concentration in both tissues, followed by Bacteroidetes and Cyanobacteria. In the most contaminated sites, Aeromonas and Pseudomonas (Proteobacteria) were predominant, while mercury concentration negatively correlated with Photobacterium (Proteobacteria) or Cerasicoccus (Verrucomicrobia). In summary, we found that mercury contamination correlates with active gill microbiota composition, with potential implications of strains in modulating mercury toxicity, making them interesting for future biomarker studies.
The Tick Microbiome: The “Other Bacterial Players” in Tick Biocontrol
Authors: Maldonado-Ruiz Paulina
Published: November 2024

Hard ticks (family Ixodidae) are one of the most predominant arthropod disease vectors worldwide, second only to mosquitoes. In addition to harboring animal and human pathogens, ticks are known to carry a microbial community constituted of non-pathogenic organisms, which includes maternally inherited intracellular endosymbionts and other environmentally acquired extracellular microorganisms. These microbial communities, which include bacteria, viruses, protozoans, and fungi—with often commensal, mutualistic, or parasitic associations with the tick—comprise the tick microbiome, bacteria being the most studied community. Many bacterial taxa frequently reported in ticks include soil, plant, and animal-associated microbes, suggesting many are environmentally acquired, including members with known entomopathogenic potential, such as Bacillus thuringiensis, Bacillus spp., and Pseudomonas spp. It has been reported that microbial community composition can impact pathogen persistence, dissemination, and fitness in ticks. In the United States, Ixodes scapularis (northeast) and I. pacificus (west) are the predominant vectors of Borrelia burgdorferi, the causal agent of Lyme disease. Amblyomma americanum is another important tick vector in the U.S. and is becoming an increasing concern as it is the leading cause of alpha-gal syndrome (AGS, or red meat allergy). This condition is caused by tick bites containing the galactose alpha 1,3 galactose (alpha-gal) epitope in their saliva. In this paper, we present a summary of the tick microbiome, including the endosymbiotic bacteria and the environmentally acquired (here referred to as the non-endosymbiotic community). We will focus on the non-endosymbiotic bacteria from Ixodes spp. and Amblyomma americanum and discuss their potential for novel biocontrol strategies.
Experimental Study on the Preparation of Cementitious Materials Through the Activation of Lead—Zinc Tailings
Authors: Wu Xu , Xu Xiuping , Li Shuqin , Li Xiangmei , Pei Dejian , Yang Xiaojun , Yu Xiankun , Zhu Xiaoman
Published: November 2024

The pozzolanic activity of lead–zinc tailings (LZTs) was enhanced through mechanical grinding, enabling the preparation of a lead–zinc tailing based composite cementitious material (LZTCC) by combining LZTs with ground granulated blast furnace slag (GGBS), steel slag (SS), and desulfurized gypsum (DG). The compressive strength of LZTCC was evaluated under varying water–cement ratios (W/C) and LZTs dosages. The hydration mechanism was studied via phase composition and microstructural analyses of hydration products. The results revealed that the 28-day pozzolanic activity of LZTs improved to 76% after 2 h of mechanical grinding. LZTCC formulated with 60% LZTs, 22% GGBS, 8% SS, and 10% DG achieved compressive strengths of 13.8 MPa at 7 days and 15.7 MPa at 28 days under a W/C ratio of 0.4. XRD and SEM characterization demonstrated that AFt and amorphous C-S-H gel, along with the unreacted LZT particles, contributed to the overall microstructure, while the former two phases played a significant role in the strength development of LZTCC mortar due to their cementitious reactivity. Heavy metal pollution levels were minimized throughout the process, and the research results could provide a scientific basis for the harmless treatment and resource utilization of LZTs.
Shedding Light on Calcium Dynamics in the Budding Yeast: A Review on Calcium Monitoring with Recombinant Aequorin
Authors: Gogianu Larisa Ioana , Ruta Lavinia Liliana , Farcasanu Ileana Cornelia
Published: November 2024

Recombinant aequorin has been extensively used in mammalian and plant systems as a powerful tool for calcium monitoring. While aequorin has also been widely applied in yeast research, a notable gap exists in the literature regarding comprehensive reviews of these applications. This review aims to address that gap by providing an overview of how aequorin has been used to explore calcium homeostasis, signaling pathways, and responses to stressors, heavy metals, and toxic compounds in Saccharomyces cerevisiae. We also discuss strategies for further developing the aequorin system in yeast, with particular emphasis on its use as a model for human calcium signaling studies, such as the reproduction of the mitochondrial calcium uniporter. By highlighting previous research and pinpointing potential future applications, we discuss the untapped potential of aequorin in yeast for drug screening, environmental toxicity testing, and disease-related studies.
Vibrational Spectrum of Magnesium Monochalcogenide Nanoparticles
Authors: Aravantinos-Zafiris Nikos , Michos Fotios I. , Sigalas Michail M.
Published: November 2024

In this work, the vibrational spectra of magnesium monochalcogenide nanoparticles were examined numerically. The calculations were performed with Density Functional Theory and the examined magnesium monochalcogenide nanoparticles were formed from an initial cubic-like unit with type Mg4Y4, where Y=S,Se,Te, after elongating this unit along one, two, and three vertical directions. Therefore, beyond the initial building block, different groups of magnesium monochalcogenide nanoparticles were examined in the form MgxYx, where x=8,16,24. Especially for the case where the chalcogen part of the nanoparticle was sulfur, another group of nanoparticles was examined where x=32. For this group of the examined nanostructures, an exotic case was also included in the calculations. Among the findings of this research was the existence of stable structures, of the examined morphologies. The calculations of this research led to the identification of both common characteristics and differences among these nanostructures. These characteristics regarding their vibrational modes could be a very useful tool, especially for experimentalists. The relevant phonon spectrum that was extracted from the calculations also provided very useful information regarding the examined nanoparticles and their potential uses in several technological applications.
Anorexia Nervosa in Polish Children and Adolescents in the Context of the COVID-19 Pandemic—An Observational Single Centre Study
Authors: Dyląg Katarzyna Anna , Skowron Kamil Paweł , Kurnik-Łucka Magdalena , Drzewiecki Łukasz , Przybyszewska Katarzyna , Król-Dykas Magdalena , Dumnicka Paulina , Gawlik Zuzanna , Gawlik Jakub , Sikora Sebastian , Gil Krzysztof
Published: November 2024

Introduction: Anorexia nervosa (AN) is a psychiatric disorder with a high mortality rate and significant prevalence in the paediatric population. Preliminary reports during the COVID-19 pandemic suggested an increased incidence of AN among children and adolescents. The objective of this study was to analyse new cases of AN before, during, and after the pandemic, with a particular focus on the physical manifestations of the disease. Methods: This single-centre, retrospective study included new AN cases from the hospital database of a regional paediatric hospital (a reference centre for AN) between 2013 and 2023. Data analysed included the duration of the disease, body mass index (BMI), weight loss, length of hospitalisation, laboratory markers (leukopenia, anaemia, hypoproteinaemia, hyperferritinaemia, hypophosphataemia, dyslipidaemia, and hypothyroxinaemia) and clinical features of malnutrition (such as amenorrhea bradycardia, pericardial effusion, and cortical/subcortical atrophy). Results: This study was conducted in a Polish regional hospital. We analysed 228 hospitalized female patients aged 10 to 18 years diagnosed with AN, focusing on clinical characteristics, biochemical markers, and the impact of the COVID-19 pandemic. The COVID-19 pandemic was shown to have a significant impact, with longer hospitalisations observed during and after the pandemic and a lower BMI on admission post-pandemic compared to pre-pandemic. In addition, nutritional treatment became more prevalent over time while biochemical markers such as anaemia, hypothyroidism, hypophosphataemia, and dyslipidaemia were statistically more common post-pandemic. Conclusions: This study demonstrates a significant impact of the COVID-19 pandemic on the clinical course and hospitalisation patterns of paediatric patients with AN. These findings suggest that the pandemic may have exacerbated disease severity and altered treatment approaches, emphasizing the need for enhanced clinical management and follow-up strategies for AN in the paediatric population during such health crises.
An Exploration of Clinical Characteristics and Treatment Outcomes Associated with Dietetic Intervention in Adolescent Anorexia Nervosa
Authors: Brennan Cliona , Felemban Lara , McAdams Ellen , Walsh Kevin , Baudinet Julian
Published: November 2024

Background: Although dietitians possess expert knowledge on the interplay between nutrition and health, their specific role in family therapy for anorexia nervosa (FT-AN) remains a topic of debate. Some of the literature indicates insufficient evidence to affirm the impact of dietetic interventions, emphasising variability in outcomes and a need for standardised research. This study aimed to identify the clinical characteristics of adolescents requiring dietetic intervention during FT-AN and to assess differences in clinical outcomes between those receiving dietetic support and those who did not. Methods: A retrospective cohort study was conducted at the Maudsley Centre for Child and Adolescent Eating Disorders in London. Patients were selected from electronic records. Inclusion criteria were ICD-10 diagnosis of AN and completion of FT-AN treatment between January 2020 and December 2022. Collected data included weight (kg and %mBMI), eating disorder symptom severity, pre-assessment anxiety (patient and parent), and details of FT-AN sessions (i.e., frequency and amount). The sample was divided into two groups: those who received dietetic input and those who did not. Statistical analyses included Mann–Whitney U tests, χ2 tests, independent t-tests, and a logistic regression to examine differences at baseline, 4–6 weeks post-assessment, and discharge. Results: The study included 92 participants (dietetic group = 33 participants; non-dietetic group = 59 participants). Baseline characteristics were comparable between groups. The logistic regression showed no significant predictors for dietetic input. At 4–6 weeks, those requiring dietetic input exhibited lower %mBMI (83.3% vs. 87.3%, p = 0.027) and poorer weight gain (+2.3 kg vs. +3.1 kg, p = 0.04). By discharge, weight restoration was similar (92% vs. 93% mBMI, p = 0.64), although the dietetic group had more therapeutic treatment sessions (24 vs. 19, p = 0.04). Discussion: This study found no specific predictors for prioritising dietetic input in young people during FT-AN treatment. While those receiving dietetic support struggled with weight gain early and attended more sessions, both groups achieved similar weight outcomes by the end of treatment. Future research should focus on the timing and content of dietetic interventions, as well as perspectives from patients and caregivers, to better understand their role and impact on cognitive and emotional recovery aspects.
Perceived Worries in the Adoption of Artificial Intelligence Among Healthcare Professionals in Saudi Arabia: A Cross-Sectional Survey Study
Authors: Alsaedi Abdulaziz , Alneami Nada , Almajnoni Fahad , Alamri Ohoud , Aljohni Khulud , Alrwaily Maha , Eid Meshal , Budayr Abdulaziz , Alrehaili Maram , Alghamdi Marha , Almutairi Eqab , Eid Mohammed
Published: November 2024

The use of AI in the healthcare sector is facing some formidable concerns raised by the practitioners themselves. This study aimed to establish the concerns that surround the adoption of AI among Saudi Arabian healthcare professionals. Materials and methods: This was a cross-sectional study using stratified convenience sampling from September to November 2024 across health facilities. This study included all licensed healthcare professionals practicing for at least one year, whereas interns and administrative staff were excluded from the research. Data collection was conducted through a 33-item validated questionnaire that was provided in paper form and online. The questionnaire measured AI awareness with eight items, past experience with five items, and concerns in four domains represented by 20 items. Four hundred questionnaires were distributed, and the response rate was 78.5% (n = 314). The majority of the participants were females (52.5%), Saudis (89.2%), and employees of MOH (77.1%). The mean age for the participants was 35.6 ± 7.8 years. Quantitative analysis revealed high AI awareness scores with a mean of 3.96 ± 0.167, p < 0.001, and low previous experience scores with a mean of 2.65 ± 0.292. Data management-related worries came out as the top worry, with a mean of 3.78 ± 0.259, while the poor data entry impact topped with a mean of 4.15 ± 0.801; healthcare provider-related worries with a mean of 3.71 ± 0.182; and regulation/ethics-related worries with a mean of 3.67 ± 0.145. Health professionals’ main concerns about AI adoption were related to data reliability and impacts on clinical decision-making, which significantly hindered successful AI integration in healthcare. These are the particular concerns that, if addressed through robust data management protocols and enhanced processes for clinical validation, will afford the best implementation of AI technology in an optimized way to bring better quality and safety to healthcare. Quantitative validation of AI outcomes and the development of standardized integration frameworks are subjects for future research.
A New Generation of Porous Polymer Materials from Polystyrene Waste: Synthesis and Adsorption of Nitrate Anions in Aqueous Media
Authors: Anannaz Mohamed , Tafraout Fatiha , Laghlimi Charaf , Ouaabou Rachida , Isaad Jalal
Published: November 2024

A simple approach was developed to efficiently graft diethylene triamine onto polystyrene waste using succinic anhydride as a tracer to remove nitrate anions from aqueous solutions. Infrared spectroscopic data showed characteristic signs at 3395 cm−1 and 1695 cm−1 corresponding to N-H and C=O (ester and amide), confirming the grafting of DETA onto PS. The zeta potential study showed that the PS-Succ-DETA adsorbent had a pHiep of 8.2, and its charge was positive when the pH was lower than the pHiep. Parameters affecting nitrate adsorption, such as dosage, initial concentration, pH, and contact time, were studied. The adsorption data corresponded well to the Langmuir isotherm with an R2 correlation coefficient of 0.998, and the adsorption capacity was found to be 195.65 mg/g. The adsorption kinetics of NO3− ions by PS-Succ-DETA corresponded perfectly to the PS-II model, with an R2 coefficient of 0.999. The negative value of ΔG (−10.02 kJ/mol), ΔH (−18.76 kJ/mol), and ΔS (−28.83 J/K/mol) indicates that NO3- adsorption is spontaneous exothermic and suggests a decrease in randomness at the solid-liquid interface during the adsorption. The mechanism of adsorption of nitrate ions onto PS-Succ-DETA occurs via electrostatic interactions and hydrogen bonds between the NO3− ions and the -NH2 and NH functions of PS-Succ-DETA.
Phenotypic and Genotypic Analysis of Antimicrobial Resistance in Mycoplasma hyopneumoniae Isolated from Pigs with Enzootic Pneumonia in Australia
Authors: Jafari Jozani Raziallah , Khallawi Mauida F. Hasoon Al , Nguyen Hanh Thi Hong , Mohammed Majed H. , Petrovski Kiro , Ren Yan , Trott Darren , Hemmatzadeh Farhid , Low Wai Yee
Published: November 2024

Mycoplasma hyopneumoniae, an important cause of enzootic pneumonia in pigs in many countries, has recently been shown to exhibit reduced susceptibility to several antimicrobial classes. In the present study, a total of 185 pig lung tissue samples were collected from abattoirs in Australia, from which 21 isolates of M. hyopneumoniae were obtained. The antimicrobial resistance profile of the isolates was determined for 12 antimicrobials using minimum inhibitory concentration (MIC) testing, and a subset (n = 14) underwent whole-genome sequence analysis. MIC testing revealed uniformly low values for enrofloxacin (≤1 μg/mL), florfenicol (≤8 μg/mL), lincomycin (≤4 μg/mL), spectinomycin (≤4 μg/mL), tetracycline (≤0.5 μg/mL), tiamulin (≤2 μg/mL), tildipirosin (≤4 μg/mL), tilmicosin (≤16 μg/mL) tulathromycin (≤2 μg/mL), and tylosin (≤2 μg/mL). Higher MICs were observed for erythromycin (MIC range: 16–32 μg/mL), gamithromycin, and tilmicosin (MIC range of both: 32–64 μg/mL). Whole-genome sequencing of the isolates and additional screening using mismatch amplification mutation assay PCR did not identify any known genetic resistance markers within 23S rRNA (macrolides), DNA gyrase A, and topoisomerase IV genes (fluoroquinolones). The WGS data also indicated that the Australian M. hyopneumoniae isolates exhibited limited genetic diversity and formed a distinct monophylectic clade when compared to isolates from other countries. These findings indicate that Australian M. hyopneumoniae likely remains susceptible to the major antimicrobials used to treat enzootic pneumonia in pigs and have evolved in isolation from strains identified in other pig-producing countries.
Systematic Review of the Occurrence and Antimicrobial Resistance Profile of Foodborne Pathogens from Enterobacteriaceae in Wild Ungulates Within the European Countries
Authors: Pătrînjan Răzvan-Tudor , Morar Adriana , Ban-Cucerzan Alexandra , Popa Sebastian Alexandru , Imre Mirela , Morar Doru , Imre Kálmán
Published: November 2024

Game meat is derived from non-domesticated, free-ranging wild animals and plays an important role in human nutrition, but it is recognized as a source of food-borne and drug-resistant pathogens impacting food safety. The present review aimed to provide a comprehensive analysis of the frequency of isolation and antimicrobial resistance (AMR) profiles of major foodborne pathogens from the Enterobacteriaceae, including Salmonella, Escherichia, and Yersinia genera, in wild ungulates, across Europe in the 21st century. A systematic search was conducted via the Google Scholar database using the PRISMA guidelines. In this regard, the content of a total of 52 relevant scientific publications from both European Union (n = 10) and non-European Union countries (n = 3) was processed, highlighting the main scientific achievements and indicating knowledge gaps and future perspectives. The studies highlighted that Salmonella spp. was the most commonly encountered pathogen, and significant AMR levels were noticed for the isolated strains, especially against penicillin (32.8%) and amoxicillin (32.1%). This review underscores the importance of monitoring the presence of food-borne pathogens and their AMR in wildlife as important public health and food safety concerns.
And Child Makes Four: The Impact of a New Child on Dog-Owning Families
Authors: Kogan Lori R. , Currin-McCulloch Jennifer , Bussolari Cori , Packman Wendy
Published: November 2024

Pets are often an integral part of the family structure, with many people viewing their pets as children and thinking of themselves as “pet parents”. Pets have been shown to provide an array of psychological and physical health benefits, but some research suggests that the effects of pet ownership are more nuanced than once thought. One common negative aspect of pet ownership is guilt. Drawing from research pertaining to the transition to siblinghood, this study explored pet owner guilt as a result of adding a child to a dog-owning family. It also measured changes in dogs’ behaviors and their impact on owners’ depression and anxiety levels. Results suggest that many parents feel dog-related guilt and struggle with the resultant changes in household dynamics with the arrival of a child. Suggestions to help improve the chances of a successful transition include awareness, preparation, and self-compassion. Planning and preparing can help minimize negative dog behaviors and, as a result, levels of parental depression and anxiety. Parents are encouraged to help their dogs succeed by taking the time to prepare beforehand, thereby minimizing their own guilt and decreasing the potential of a severed human–dog bond.
Transcranial Magnetic Stimulation Enhances the Therapeutic Effect of IGF-Trap in Intracerebral Glioma Models
Authors: Perrino Stephanie , Vazana Udi , Prager Ofer , Schori Lior , Ben-Arie Gal , Minarik Anna , Chen Yinhsuan Michely , Haçariz Orçun , Hashimoto Masakazu , Roth Yiftach , Pell Gabriel S. , Friedman Alon , Brodt Pnina
Published: November 2024

Background: Glioblastoma multiforme is an aggressive malignancy with a dismal 5-year survival rate of 5–10%. Current therapeutic options are limited, due in part to drug exclusion by the blood–brain barrier (BBB). We have previously shown that high-amplitude repetitive transcranial magnetic stimulation (rTMS) in rats allowed the delivery across the BBB of an IGF signaling inhibitor—IGF-Trap. The objective of this study was to assess the therapeutic effect of IGF-Trap when delivered in conjunction with rTMS on the intracerebral growth of glioma. Results: We found that systemic administration of IGF-Trap without rTMS had a minimal effect on the growth of orthotopically injected glioma cells in rats and mice, compared to control animals injected with vehicle only or treated with sham rTMS. In rats treated with a combination of rTMS and IGF-Trap, we observed a growth retardation of C6 tumors for up to 14 days post-tumor cell injection, although tumors eventually progressed. In mice, tumors were detectable in all control groups by 14–17 days post-injection of glioma GL261 cells and progressed rapidly thereafter. In mice treated with rTMS prior to IGF-Trap administration, tumor growth was inhibited or delayed, although the tumors also eventually progressed. Conclusion: The results showed that rTMS could increase the anti-tumor effect of IGF-Trap during the early phases of tumor growth. Further optimization of the rTMS protocol is required to improve survival outcomes.
Precision and Stability of a Space Laser Ranging Technology Based on Time-Frequency Co-Transfer
Authors: Li Shaobo , Zhang Lei , Wang Dongjie , Hu Yuhan , Lv Mingyang , Li Zhe , Li Yihan
Published: November 2024

This paper presents an innovative space laser ranging technology that utilizes time-frequency co-transfer, effectively meeting the critical demand for precision in space laser ranging applications. The aim is to achieve high-precision ranging by calculating the transfer time using a bidirectional comparison scheme for clock synchronization and an active compensation technique for frequency transfer. Experimental results indicate that, over a 500 m optical path, an impressive ranging accuracy of 0.0005 m is achieved, reflecting significant improvements in precision, stability, and resistance to interference. By integrating time synchronization, frequency transfer, and free-space laser ranging into a cohesive system, this technology demonstrates substantial potential for a wide range of applications.