bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolución de la producción científica generada sobre la dehiscencia del canal semicircular posterior
Authors: Cisneros-Gimeno Ana Isabel , García-Barrios Alberto , Escuer-Albero Guillermo , Obón-Nogués Jesús , White-Orozco Jaime
Published: October 2023

Introducción:
La dehiscencia del canal semicircular posterior es una vestibulopatía rara, de baja prevalencia y cuya sintomatología se explica por el fenómeno de la tercera ventana. No fue hasta 2003 cuando Krombach describe los primeros casos.

Objetivo:
Evaluar mediante análisis bibliométrico y temático la producción científica sobre trabajos de dehiscencia del canal semicircular posterior (DCSP) y su incidencia a nivel de la comunidad científica mediante una revisión bibliográfica.

Método:
Se realiza búsqueda, revisión, selección y estudio a partir de ítems relacionados con DCSP indexados en la base de datos Pubmed, Web of Science, Alcorze y Scopus, desde el año 2003 hasta 2019, seleccionando 90 artículos.

Resultados:
Los 90 artículos han sido publicados en un total de 48 revistas, siendo 52% originales, 38% casos clínicos, 9% revisiones y 1% conferencias. La temática predominante fue la clínica (32%) y la etiología (27%). Los artículos estaban escritos en ocho idiomas diferentes, predominando el inglés (85%), y siendo Estados Unidos el país con más publicaciones (42%). Los índices de actividad institucional y autoría son bajos. La calidad de las revistas es alta, ya que el 70% de las publicaciones se encontraban en los cuartiles Q1-Q2. El área principal es Otorrinolaringología, con 66 trabajos, seguida por Radiología con 14. El número de descargas fue 6958, con una media de 77,31 por artículo, y las citaciones fueron 1193, equivalente a una media de 13,25.

Conclusión:
Los datos bibliométricos revelan cómo los trabajos sobre dehiscencia del canal semicircular posterior representan una pequeña producción científica, el tema está en fase de crecimiento sostenido, los índices de autoría, institucionalidad y colaboración son bajos y las publicaciones se concentran en pocas revistas, con una orientación claramente anglófona, pero de alta calidad e importante visualización.
Synthesis, Characterization, Antimicrobial and Cytotoxic Investigations of Some Transition Metal(II) Complexes with Tridentate Schiff Base Derived from Pyrrolopyrimidine
Authors: BAGUL ABHAY , GAIKWAD DIGAMBER , PATIL YOGESH , BHUSARI NILESH
Published: October 2023

A Schiff base pyrrolopyrimidine-hydrazide-m-chlorobenzaldehyde (HPPHmCB) was synthesized via condensation reaction between a pyrrolopyrimidinehydrazide and 3-chlorobenzaldehyde and its transition metal(II) complexes complexes followed by the characterization and electrochemical analysis. The magnetic susceptibility, electrolytic conductivity, elemental analysis, FT-IR, electronic absorption, ESR and PMR spectra were employed to elucidate the structural properties. The Schiff base HPPHmCB ligand acts as a tridentate N,N,N donor and produces complexes of type [M(PPHmCB)2], which exhibit a square planar geometry for Pd(II) complex, tetrahedral for Hg(II), Cd(II) and Zn(II) complexes and octahedral geometry for Mn(II), Cu(II), Fe(II), Co(II) and Ni(II) complexes. The minimum inhibitory concentration (MIC) approach was used to screen the in vitro antibacterial and antifungal activities of synthesized Schiff base HPPHmCB ligand and its metal(II) complexes. The results showed that the significant microbial activities by both ligand and its transition metal(II) complexes. Moreover, in vitro cytotoxicity properties of Schiff base HPPHmCB ligand and its metal(II) complexes were also investigated against Artemia salina using the brine shrimp bioassay.
Are there network differences between the ipsilateral and contralateral hemispheres of pain in patients with episodic migraine without aura?
Authors: Jang Junseok , Ryu Sungyeong , Lee Dong Ah , Park Kang Min
Published: October 2023

Background: We aimed to identify any differences in the structural covariance network based on structural volume and those in the functional network based on cerebral blood flow between the ipsilateral and contralateral hemispheres of pain in patients with episodic migraine without aura.Methods: We prospectively enrolled 27 patients with migraine without aura, all of whom had unilateral migraine pain. We defined the ipsilateral hemisphere as the side of migraine pain. We measured structural volumes on three-dimensional T1-weighted images and cerebral blood flow using arterial spin labeling magnetic resonance imaging. We then analyzed the structural covariance network based on structural volume and the functional network based on cerebral blood flow using graph theory. Results: There were no significant differences in structural volume or cerebral blood flow between the ipsilateral and contralateral hemispheres. However, there were significant differences between the hemispheres in the structural covariance network and the functional network. In the structural covariance network, the betweenness centrality of the thalamus was lower in the ipsilateral hemisphere than in the contralateral hemisphere. In the functional network, the betweenness centrality of the anterior cingulate and paracingulate gyrus was lower in the ipsilateral hemisphere than in the contralateral hemisphere, while that of the opercular part of the inferior frontal gyrus was higher in the former hemisphere.Conclusions: The present findings indicate that there are significant differences in the structural covariance network and the functional network between the ipsilateral and contralateral hemispheres of pain in patients with episodic migraine without aura.
Effect of aging on mechanical properties of 3D printed samples using stereolitography
Authors: Drechslerová Veronika , Falta Jan , Fíla Tomáš , Dvo˚řák Radim , Kytýř Daniel
Published: October 2023

This paper focuses on stereolithography (an additive manufacturing technology working on the principle of curing liquid resins layer by layer using ultraviolet radiation) and the effect of aging on the mechanical properties of the material and printed samples. The aging of the material could be a problem for its subsequent use as the stability of the mechanical properties would not be maintained and unwanted deterioration of the material could occur. As part of the research, sets of samples were printed and subjected to different aging methods and subsequently subjected to quasi-static and dynamic uni-axial load tests. From the data obtained, the basic mechanical properties of the material were calculated and compared with each other. The aim of this paper was to investigate whether aging process causes significant changes in the mechanical properties of the materials used, which could have a consequential impact on their use in different industries.
Truth be told: a corpus-based study of the cross-linguistic colexification of representational and (inter)subjective meanings
Authors: Beekhuizen Barend , Blumenthal Maya , Jiang Lee , Pyrtchenkov Anna , Savevska Jana
Published: October 2023

The study of crosslinguistic variation in word meaning often focuses on representational and concrete meanings. We argue other kinds of word meanings (e.g., abstract and (inter)subjective meanings) can be fruitfully studied in translation corpora, and present a quantitative procedure for doing so. We focus on the cross-linguistic patterns for lemmas pertaining to truth and reality (English true and real), as these abstract meanings been found to frequently colexify with particular (inter)subjective meanings. Applying our method to a corpus of translated subtitles of TED talks, we show that (1) the abstract-representational meanings are colexified in patterned ways, that, however, are more complex than previously observed (some languages not splitting a ‘true’-like from ‘real’-like terms; many languages displaying further splits of representational meanings); (2) some non-representational meanings strongly colexify with representational meanings of ‘truth’ and ‘reality’, while others also often colexify with other fields.
A dimension expanded preconditioning technique for block two-by-two linear equations
Authors: Luo Wei-Hua , Carpentieri Bruno , Guo Jun
Published: October 2023

In this article, we introduce a novel block preconditioner for block two-by-two linear equations by expanding the dimension of the coefficient matrix. Theoretical results on the eigenvalues distribution of the preconditioned matrix are obtained, and a feasible implementation is discussed. Some numerical examples, including the solution of the Navier-Stokes equations, are presented to support the theoretical findings and demonstrate the preconditioner’s efficiency.
Macrophages and microglia in inflammation and neuroinflammation underlying different pain states
Authors: Chen Ouyang , Luo Xin , Ji Ru-Rong
Published: October 2023

Pain is a main symptom in inflammation, and inflammation induces pain via inflammatory mediators acting on nociceptive neurons. Macrophages and microglia are distinct cell types, representing immune cells and glial cells, respectively, but they share similar roles in pain regulation. Macrophages are key regulators of inflammation and pain. Macrophage polarization plays different roles in inducing and resolving pain. Notably, macrophage polarization and phagocytosis can be induced by specialized pro-resolution mediators (SPMs). SPMs also potently inhibit inflammatory and neuropathic pain via immunomodulation and neuromodulation. In this review, we discuss macrophage signaling involved in pain induction and resolution, as well as in maintaining physiological pain. Microglia are macrophage-like cells in the central nervous system (CNS) and drive neuroinflammation and pathological pain in various inflammatory and neurological disorders. Microglia-produced inflammatory cytokines can potently regulate excitatory and inhibitory synaptic transmission as neuromodulators. We also highlight sex differences in macrophage and microglial signaling in inflammatory and neuropathic pain. Thus, targeting macrophage and microglial signaling in distinct locations via pharmacological approaches, including immunotherapies, and non-pharmacological approaches will help to control chronic inflammation and chronic pain.
Crystal structure of bis(benzene-1 carboxylato-O 3,5-carboxyl-κ
1O)-[(5,5,7,12,12,14-hexamethyl-1,4,8,11-tetraazacyclotetradecane-κ
4
N,N′,N′′,N′′′)nickel(II) ─ benzene-1,3,5-tricarboxylic acid ─ water (1/2/4), C52H66N4NiO28
Authors: Chen Xiao-Ming , Ou Guang-Chuan
Published: October 2023

C52H66N4NiO28, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 11.292(6) Å, b = 11.670(6) Å, c = 12.165(6) Å, α = 81.872(6)°, β = 67.036(5)°, γ = 75.624(6)°, V = 1428.1(12) Å3, Z = 1, Rgt
(F) = 0.0439, wRref
(F
2) = 0.1216, T = 296(2) K.
The crystal structure of the salt: 4-((1,3-dioxoisoindolin-2-yl)carbamoyl)pyridine-1-ium 2-carboxybenzoate, C14H10N3O3·C8H5O4
Authors: Smith Mark G.
Published: October 2023

C14H10N3O3·C8H5O4, triclinic,

P

1
‾

$P\overline{1}$

(no. 2), a = 8.1312(3) Å, b = 10.5732(4) Å, c = 12.0961(4) Å, α = 

110.933

(
2
)

∘

$110.933{(2)}^{\circ }$

, β = 

101.603

(
2
)

∘

$101.603{(2)}^{\circ }$

, γ = 

91.295

(
2
)

∘

$91.295{(2)}^{\circ }$

, V = 946.37(6) Å3, Z = 2,

R

g
t

${R}_{gt}$

(F) = 0.0493,

w

R

r
e
f

$w{R}_{ref}$

(F
2) = 0.1369, T = 173 K.
ICAP Taxonomy of Modes of Cognitive Engagement: A Learner-Centered Theory Focusing on Observable Engagement Behaviors
Authors: Cheng Xiaoqiao
Published: October 2023

Historically, there have been a number of impactful education theories that used the taxonomy as a classification device, such as the Bloom taxonomy of educational objectives and Gagne taxonomy of learning outcomes. The Bloom taxonomy of educational objectives was developed in the 1950s by the U.S. Committee of College and University Examiners under the leadership of Dr. Benjamin Bloom, which categorizes educational objectives into three domains: cognitive, affective, and psychomotor. Among them, the cognitive domain (the main concern of their research) contains six major classes: knowledge, comprehension, application, analysis, synthesis, evaluation. They are arranged in a hierarchical order with the objectives in one class built on the behaviors found in the preceding classes. Its primary purpose is to provide classification of goals of the educational system for all teachers, administrators, professional specialists, and research workers who deal with curricular and evaluation problems (Committee of College and University Examiners, 1956). Gagne’s theory approaches learning from the viewpoint of the instruction. Under his taxonomy, the five categories of learning outcomes are verbal information, intellectual skills, cognitive strategies, motor skills, and attitudes, each of which requires necessary conditions to achieve and corresponds to specific principles of instructional events (Gagne, 1984).
Significance of Assessment in Learning: The Role of Educational Assessment Tools
Authors: Zhou Ming
Published: October 2023

It has been widely acknowledged that assessment is an integral part of any effective educational system. It involves a wide variety of methods or tools that educators use to evaluate, measure, and document the academic readiness, learning progress, skill acquisition, and academic results of students. In his Dictionary of Education Evaluation, Tao (1998) defines educational assessment as a process in which educators make objective evaluation of educational activities, processes, and outcomes through systematic information collection and analysis by using practical, scientific methods, with the purpose of supporting students’ continuous improvement and providing evidence for educational decision-making.
Developing Comprehensive Competences of College Students through Sports: The Role of Slow Pitch Softball Training
Authors: Lin Chengnan
Published: October 2023

The cultivation of comprehensive competencies is crucial to college students’ development. It is a primary goal of higher education and a need for social development. Currently, issues such as unhealthy mental tendencies, insufficient social skills, and weak social adaptability exist among some Chinese college students. Against the backdrop of promoting college students’ holistic development through physical education, this study analyzed the roles of slow pitch softball in boosting college students’ key competencies based on the features of this sport and proposed suggestions for optimizing slow pitch softball training in college physical education.
Análisis de función y rendimiento de un banot como jabalina
Authors: Cejudo Ventura Juan Antonio
Published: October 2023

En este artículo se explorará el uso del banot como una jabalina en las sociedades prehispánicas de las Islas Canarias. Mediante la consulta de fuentes históricas de la conquista de las islas, recopiladas por autores como Juan Luis Cuscoy se intenta aclarar el uso de esta herramienta por estas sociedades. También se realiza una pequeña investigación etnográfica intentado buscar paralelismos entre la cultura canaria actual y la aborigen, para significar el uso del banot en el pasado. Con todas estas fuentes se recreará una réplica de un banot que se encuentra depositado en el Ayuntamiento de La Orotava con la finalidad de comprobar su utilidad como jabalina. Para comprobar esta funcionalidad se comparará con otras piezas similares como el soliferreum procedente de la península ibérica, ya que este presenta una tipología similar. Se realizará una experimentación en la que primero se buscará la forma óptima de lanzar la pieza, utilizando diferentes técnicas. Seguidamente se analizará la distancia máxima que es capaz de recorrer la pieza, y por último se discurrirá sobre qué papel juega el abultamiento en la pieza, para aclarar si se trata de un asidero o tiene algún otro tipo de utilidad. Además, se busca aclarar la importancia de estas piezas para los aborígenes canarios y si sería una herramienta común o algo reservado para personajes de prestigio, así como el número de piezas que portaría cada individuo.
La deforestación en el Neolítico y Calcolítico: El paso del hacha pulimentada al hacha de cobre
Authors: Calvo García Iván
Published: October 2023

En este trabajo se trata de estudiar como el desarrollo de la lítica y la metalurgia que vino con el incremento de la complejidad social y de las actividades socioeconómicas, conllevó a la deforestación y adaptación del medioambiente a sus necesidades. Para ello, se va a realizar y enmangar un hacha de sílex y un hacha de cobre al estilo de un hacha-azuela, y probarla sobre madera, pudiendo percibir sus huellas de uso de forma microscópica y macroscópica, todo ello con la intención de ver si el desarrollo tecnológico ayudó a la deforestación durante el Neolítico y el Calcolítico.
Hydrophobic microcrystalline cellulose/polyethyleneimine composite aerogel for effective sound absorption
Authors: Jia Xin , Tang Guijiang , Gao Jinming , Liao Yangmiao , Zhang Yu , Jiang Xueliang , Yang Huan , Wu Dan , You Feng , Yu Peng , Yao Chu
Published: October 2023

A hydrophobic and ultralight cellulose aerogel (CA) was reinforced by polyethyleneimine (PEI) and functionalized by methyltrimethoxysilane (MTMS). Adding PEI improved the mechanical strength and the elastic resilience of the resulting material due to the flexibility enhancement of the cellulose chains, which prevented the collapse of the pore structure and contributed to the uniform pore size distribution. The hydrophobic property of the aerogels with the functionalization of MTMS was improved, which can prevent the pore structure from collapsing due to the absorption of water. The maximum compression modulus of aerogel reached 1.1 MPa at the strain of 80%, and its hydrophobic water contact angle was up to 112°. The hydrophobic composite aerogels exhibited ultrahigh efficiency in sound absorption across a wide frequency range from 500 to 6300 Hz, and their average absorption coefficient was greater than 0.74. The light weight, high porosity, and environmentally friendly aerogels presented in this work are promising for efficient sound absorption. They have potential applications in noise pollution treatment.
Evaluation and production of high-strength wood composite panels with polyethylene terephthalate (PET)
Authors: Campos Pedro H. S. , Santos Junior Antonio J. , de Souza Matheus V. , Herradon Marjorie P. , Libera Vitória B. L. , Dezen Lucas. E. , da Silva Élen V. , Silva Ananda G. B. P. , Rodrigues Felipe R. , Bispo Rodrigo A. , Cazella Pedro H.S. , da Silva Sérgio A.M. , Christoforo André L.
Published: October 2023

To reduce dependence on wood and deforestation, alternative materials have been considered. This research evaluated particleboards panels of Pinus elliotti mixed with residues of polyethylene terephthalate (PET) in flakes with 50% of each material, glued with 10% of castor oil-based polyurethane resin (PUR). The temperature during board production was varied to evaluate its influence on the physical and mechanical properties of the boards. The study concludes that the increase in temperature did not result in a significant improvement in the particleboard properties, but their results showed application potential according to the normative standards.
Postnatal Corticosteroids To Prevent Bronchopulmonary Dysplasia
Authors: Jensen Erik A. , Watterberg Kristi L.
Published: October 2023

Bronchopulmonary dysplasia (BPD) is a common, severe chronic respiratory disease that affects very preterm infants. In utero and postnatal exposure to proinflammatory stimuli contribute to the pathophysiology of BPD. Corticosteroids, because of their potent anti-inflammatory properties, may decrease respiratory morbidity and reduce the risk of BPD in very preterm infants. However, these medications can have adverse effects on the developing brain and other organ systems. This review examines current evidence on the risks and benefits of postnatal corticosteroids used to prevent BPD in preterm infants.
CPT 2024: Coding Changes for Cardiac Imaging Services
Authors:   American Academy of Pediatrics
Published: October 2023

New codes will be implemented for services performed on and after January 1, 2024, for imaging performed to evaluate congenital cardiac abnormalities. Changes to codes for cardiac imaging in Current Procedural Terminology (CPT®) in 2024 include the following:

Diagnostic intraoperative epicardial cardiac ultrasound (eg, echocardiography) for congenital heart disease Venography for congenital heart defect(s)

This article provides an overview of the new codes and reporting instructions. Please see your CPT 2024 reference for more information.
Comunicação interna como encruzilhada biopolítica
Authors: Mafra Rennan Lanna Martins
Published: October 2023

Este texto, de caráter ensaístico e imbuído de uma abordagem afetiva, busca narrar a comunicação interna como um conjunto de interações vinculadas de modo imediato à gestão organizacional e atravessado pela materialização da ideologia do progresso, nos ambientes relacionais das organizações modernas. A partir disso, o texto vislumbra a comunicação interna como encruzilhada biopolítica, tonalizada pela intensificação de passados (historicidades), por diferenças desatualizadas (latências) e por atmosferas de melancolia, frente a futuros falidos e a emergências furtivas de uma biopotência.
Predicate Abstraction Refinement in Thread-Modular Analysis
Authors: Rudenchik Veronika Pavlovna , Andrianov Pavel Sergeevich
Published: October 2023

Thread-modular approach over predicate abstraction is an efficient technique for software verification of complicated real-world source code. One of the main problems in the technique is a predicate abstraction refinement in a multithreaded case. A default predicate refiner considers only a path related to one thread, and does not refine the thread-modular environment. For instance, if we have applied an effect from the second thread to the current one, then the path in the second thread to the applied effect is not refined. Our goal was to develop a more precise refinement procedure, reusing a default predicate refiner to refine both: a path in a current thread and a path to an effect in the environment. The idea is to construct a joined boolean formula from these two paths. Since some variables may be common, a key challenge is to correctly rename and equate variables in two parts of the formula to accurately represent the way threads interact. It is essential to get reliable predicates that can potentially prove spuriousness of the path. The proposed approach is implemented on top of CPAchecker framework. It is evaluated on standard SV-COMP benchmark set, and the results show some benefit. Evaluation on the real-world software does not demonstrate significant accuracy increase, as the described flaw of predicate refinement is not the only reason of false positive results. While the proposed approach can successfully prove some specific paths to be spurious, it is not enough to fully prove correctness of some programs. However, the approach has further potential for improvements.
Debugger for Declarative DSL for Telecommunication
Authors: Skazhenik Taras Mikhailovich , Koznov Dmitry Vladimirovich
Published: October 2023

Development of telecommunication product lines is still a very labor-intensive task, involving a great amount of human resources and producing a large number of development artifacts — code, models, tests, etc. Declarative domain-specific languages (DSLs) may reasonably simplify this process by increasing the level of abstraction. We use the term “declarative” implying that such a DSL does not enable the development of a closed software application, but rather supports creation, generation and maintenance of various kind of software assets — product database, events and event handlers, target code data structures, etc. At the same time, such a DSL may have some executable semantic, but it could be very specific and have many environment-wise requirements. Thus, execution and debugging of such DSL specifications is a meaningful task, which has no common solution due to the unique executable semantic. Consequently, it is not possible to use debug facilities of known DSL environments, such as xtext, MPS, etc. for such a case. In the current paper, we present a debugger for DevM — a declarative DSL intended for support device management in software development in the context of a router product line by a large telecommunication company. We clarify executable semantic for DevM, making it possible to execute DevM specifications in an isolated environment, i.e. in simulation mode, without generation of target code. We use a graphic model-based notation to depict every step of execution. Finally, we implement and integrate the debugger in the DevM IDE, using Debug Adapter Protocol and language server architecture combined with the Eclipse xText/EMF tool chain.
Jugaad Authorities
Authors: Parciack Ronie
Published: October 2023

This article analyzes the figures of four contemporary Sufi peers who have established a formally unrecognized yet authoritative position despite their lack of ties to established Sufi transmission lineages or access to either symbolic or concrete capital. These peers operate in the lower strata of Delhi's urban society, in ‘economies of despair’, composed of concentric circles of unfavourable life circumstances, limited resources, under-recognition and the deepening communal divide.

Through a methodological combination ­of ethnography, participatory observation and textual analysis I examine their life trajectories to better understand the ways in which  hyperlocal peers craft jugaad (improvised) authorities­­­­­; the issue of space–the aspiration to exert power over a shrine and the transformation of the space, in some cases, from concrete to virtual. Finally, I address the transformations in peer-mureedi relations in the neoliberal era through the prism of the consumer society.
Juan R. VÉLEZ (ed.), A Guide to John Henry Newman. His Life and Thought, Washington: The Catholic University of America Press, 2022, 448 pp., 16,5 x 23,5, ISBN 978-08-1323-585-1.
Authors: Izquierdo César
Published: October 2023

Book Review
Eduardo PIRE MAYOL, El Domingo de Ramos en la liturgia Hispano-Mozárabe. Estudio comparado de liturgias occidentales, Barcelona: Ateneu Universitari San Pacià, Institut de Litúrgia ad instar Facultatis, Facultat de Teologia de Catalunya, 2022, 509 pp., 17 x 24, ISBN 978-84-126103-2-1.
Authors: Arocena Félix-María
Published: October 2023

Book Review
MicroRNA-99b Regulates Bacillus Calmette-Guerin-Infected Immature Dendritic Cell-Induced CD4+ T Cell Differentiation by Targeting mTOR Signaling
Authors: Zhen Libo , Chen Yuanyuan , Gao Juwei , Li Boying , Jia Yangmin
Published: October 2023

This study aimed to elucidate the mechanisms by which microRNA-99b (miR-99b) regulates CD4+ T cell differentiation induced by Bacillus Calmette-Guerin (BCG)-infected immature dendritic cells (imDCs). Levels of miR-99b, interferon-gamma (IFN-γ), Foxp3, interleukin (IL)-10, IL-17, IL-23, and ROR-γt were assessed. Effects of miR-99b inhibition and mechanistic target of rapamycin (mTOR) agonist on Th17/Treg cell ratio and cytokine levels (IL-6, IL-17, IL-23) were studied. Expression of mTOR, S6K1, and 4E-BP1 related to miR-99b was analyzed. BCG-infected imDCs led to CD4+ T cell differentiation and altered levels of IFN-γ, Foxp3, IL-10, miR-99b, IL-17, IL-23, and ROR-γt. Inhibition of miR-99b increased the Th17/Treg cell ratio in CD4+ T cells co-cultured with BCG-infected imDCs, and this effect was further enhanced by the mTOR agonist. Additionally, the miR-99b inhibitor elevated the levels of IL-6, IL-17, and IL-23 when CD4+ T cells were co-cultured with BCG-infected imDCs, and the mTOR agonist further amplified this increase. Notably, miR-99b negatively regulated mTOR signaling, as the miR-99b inhibitor upregulated the expression levels of mTOR, S6K1, and 4E-BP1 while decreasing miR-99b. It was concluded that miR-99b modulates CD4+ T cell differentiation via mTOR pathway in response to BCG-infected im-DCs. Inhibiting miR-99b affects Th17/Treg ratio and pro-inflammatory cytokines, potentially impacting tuberculosis immunotherapies.
ПРОБЛЕМА АВТОРСТВА ПРИ ИСПОЛЬЗОВАНИИ СИСТЕМ ИСКУССТВЕННОГО ИНТЕЛЛЕКТА ДЛЯ СОЗДАНИЯ РИД
Authors: ЧЕРНОУСОВ Дмитрий Анатольевич
Published: October 2023

Исследуется проблема авторства при использовании систем искусственного интеллекта для создания результатов интеллектуальной деятельности. Цель исследования — выявление существующего состояния правового регулирования исследуемых правоотношений и видение его развития. Выделено существующее правовое положение систем искусственного интеллекта в праве Российской Федерации, включая обобщение судебной практики на исследуемую тему. Используя концептуальный подход к работе искусственного интеллекта, автор выявил существо феномена и обратил внимание на прогнозируемое развитие систем искусственного интеллекта. Исследован вопрос о «сознании» систем искусственного интеллекта, применен подход с точки зрения квантовой механики и ее интерпретаций. Выдвинуто предположение о возможности существования у искусственного интеллекта своего «сознания». Выделено несколько видов взаимодействия человека и феномена при создании результатов интеллектуальной деятельности (РИД), охраняемых законом. Рассмотрено явление с точки зрения подражания человеческому мозгу, через призму его характеристики как нелинейной динамической системы, подверженной влиянию хаоса. Приведен пример роста скорости развития систем искусственного интеллекта и высказано убеждение о необходимости учета данного фактора при правовом регулировании. Предложен инструмент для отнесения видов взаимодействия человека и систем искусственного интеллекта (СИИ) для определения объема охраняемых прав и авторства на РИД: проведение экспертизы работы систем на предмет охраны результата их работы как РИД в зависимости от объема взаимодействия для предоставления таким результатам статуса охраняемых. В результате таких экспертиз возможно выделение для охраны результатов не как РИД, а как специального субъекта авторского права.
What Are the Current Status and Educational Needs of Global Health Education in Medical Schools? A Nationwide Survey in Korea
Authors: Kim Songrim , Kyung Sun Young , Park Ie Byung , Park Kwi Hwa
Published: October 2023

This study investigated the current status and educational needs of global health education (GHE) at medical schools in Korea. Among the 40 medical schools nationwide, 32 schools that agreed to participate in the study collected data through a survey in 2022, and the results were examined by frequency analysis and content analysis. In total, 87.5% of medical schools included global health-related graduation outcomes. In the curriculum, global health lessons within courses were present at 71.9% of medical schools. Regarding extracurricular activities, 66.7% and 63.0% of medical schools offered overseas clerkships and overseas volunteer work, respectively. Although there were not many medical schools with a global health-related educational environment, 96.9% of schools agreed with the necessity of GHE in medical education. The prevailing opinion was that it was appropriate to continuously cover GHE as lessons within courses throughout all years of the program in medical education. The main opinions regarding the improvement of GHE related to curriculum development, personnel expansion, and awareness improvement at medical schools. These findings are expected to serve as a basis for identifying the current status of GHE at Korean medical schools and specifying future directions of GHE.
Instructional Design for Systems Thinking Education in Health Systems Science
Authors: Kim Sejin , Lee Sangmi T , Lee Danbi , Yoon Bo Young
Published: October 2023

Systems thinking, a linking domain of health systems science (HSS), is an approach that investigates specific problems from a holistic perspective. It supports improving patients’ health, fulfilling their health needs, and anticipating issues that threaten patient safety within the healthcare system. It also helps solve problems through critical thinking and reflection. This study aimed to develop an curriculum on systems thinking, explore the effectiveness of the course, and investigate the applicability of HSS education at individual universities. In this study, the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) model was utilized to design, develop, implement, and evaluate an elective course on systems thinking. In the design process, learning outcomes and goals were developed, and educational content, teaching-learning methods, and student evaluation methods were linked. In the development process, class materials and evaluation materials were prepared. In the implementation process, the course was implemented, and the evaluation process analyzed the results of learning performance and curriculum assessments. The evaluation found the following results. First, the students in the study realized the importance of systems thinking and experienced the need for systems thinking through non-medical and medical situations. Second, the students were very satisfied with the learning activities in the course (mean=4.84), and the results of the self-competence evaluation, conducted before and after the course, also showed a significant improvement. This study confirmed the effectiveness of the elective course, and its results can serve as a reference for developing an HSS curriculum .
DNA extraction - Zooplankton - 96 wells v2
Authors: not provided coline.royaux
Published: October 2023

This protocol was used to extract DNA from whole or parts of zooplanktonic freshwater crustaceans (Copepoda, Branchiopoda, ...) from New Caledonia.
Together, but Alone: A Thematic Analysis of the Athletes’ and Their Partners’ Experience of Physical Separation in Romantic Relationships
Authors: Waligórska Daria , Frydrychowicz Monika , Adamczyk Katarzyna , Rogowski Wojciech , Ochnik Dominika
Published: October 2023

Athletes and their romantic partners may experience physical separation as a result of the frequent athletes’ training camps. Little is known about how such couples experience this separation. To fill this gap, the current interview-based research examined how three pairs of Polish athletes aged 22-30 (M = 23.50, SD = 25.17) experience separation in their relationships. The thematic analysis identified four themes: 1) Perception of separation as an element of the relationship; 2) Emotions during separation; 3) Maintaining contact during separation; and 4) Coping with separation. The findings revealed that athletes and their partners perceived separation as a stage, opportunity, necessity, and natural part of their relationships. Emotions related to separation ranged from negative through mixed to positive. Partners maintained regular contact, which provided closeness and continuity in their relationships despite the distance. Finally, partners coped with separation by accepting its necessity, enhanced by the awareness of the realities of sport life. They also coped with separation through mutual support, self-realization, distraction and being among other people and seeking support from them. This study suggests that physical separation in romantic relationships may be an essential and multifaceted part of the participants’ experiences in the romantic functioning and sports careers.
Causes and consequences of changes in the values of hydraulic characteristics of metal water supply and sanitation networks during their operation
Authors: Prodous Oleg A. , Shlychkov Dmitry I. , Yakubchik Petr P.
Published: October 2023

Purpose: It consists in carrying out a comparative analysis of the values of the characteristics of the hydraulic potential of metal pipelines used in assessing the energy consumption of pumping units installed on pipelines with different thickness of the layer of internal deposits.

Methods: The reasons for changing the values of hydraulic characteristics of metal pipelines during their operation are developed in tabular form. A concrete example shows the change in the values of the characteristics of the hydraulic potential of pipes with different thickness of the layer of internal deposits included in the calculated dependence for determining the actual energy consumption of pumping units.

Results: It is proposed to develop for the entire range of manufactured steel pipes and pipes made of gray cast iron, a scale of maximum permissible values of the thickness of the layer of internal deposits, according to which a decision should be made to continue or stop the operation of pipe wires.Conclusion: To recommend, based on the hydraulic calculation of the characteristics of the hydraulic potential of pipes for the given example, minimizing the use of steel and cast iron pipes made of gray cast iron in projects of water supply and drainage networks. When operating metal pipelines, take into account the dynamics of changes in the energy consumption of pumping units with different thickness of the layer of internal deposits.
Analysis of the operating conditions of contactless seals during reciprocating motion of plunger pairs of drives of construction machines
Authors: Krestin Evgeny A. , Serebryakov Grigoriy V.
Published: October 2023

Hydraulic drive of construction machines and mechanisms used in technological construction processes is increasingly being used in the construction industry. This is due to the small weight and small overall dimensions per unit of drive power, insignificant inertia of moving parts, good dynamic characteristics, ease of reversing, smooth running, durability of mechanisms due to self-lubricity, simplicity and reliability of operation. The reliability of the hydraulic drive of construction machines is largely determined by the effectiveness of the lubrication system of contactless seals of movable joints. The stability of characteristics, efficiency and safety of operation of mechanisms and hydraulic drive, in particular, depends on the quality of lubrication of sliding surfaces. In order to improve the quality and durability of the hydraulic drive for a certain range of plunger diameters and pressure drops in hydraulic units, the most rational means of combating dry friction forces is a slit non-contact seal.
TRANSFORMATIONS OF URBAN SPACE IN LVIV IN THE CONTEXT OF CREATING GREEN INFRASTRUCTURE IN RIASNE MICRO-DISTRICT
Authors:   Ivan Franko National University of Lviv, Ukraine, POLIANSKYI Yurii , SHCHURYK Khrystyna ,   Taras Shevchenko National University of Kyiv, Ukraine
Published: October 2023

Understanding the many interrelationships between humans and natural environment is increasingly important in light of significant socio-ecological challenges such as large-scale biodiversity loss and global climate change. How people conceptualize, evaluate, and embody human-nature interactions is largely the result of diverse disciplinary, theoretical, sociocultural, and political contexts. Over the past five years, the city of Lviv has become a platform for implementing the modern practices in the field of spatial planning and urban development. The introduction of separate public transport lanes, convenient and inclusive public spaces and comfortable green zones steadily increases the city's ranking position. At the same time, not all districts and neighbourhoods of the city have developed plans and projects that could locally improve the standard of living and comfort of city residents. The article presents the development of the Green Line project for one of the most remote micro-districts in the city of Lviv – Riasne. Taking into account global trends and international practices, it is concluded that green connections, which can connect several important areas within the neighbourhood and provide fast and comfortable routes for pedestrians and cyclists, will be a significant addition to the neighborhood's architectural landscape. The implementation of the Green Line project will help address several issues, including the division of the micro-district into Riasne-1 and Riasne-2, a lack of recreational areas, green public spaces, and underdeveloped pedestrian and bicycle accessibility. An analysis of the historical context, socio-economic development, and current transformations has allowed the development of a project that can be used in the future to create new green areas and connections in this research neighbourhood. An essential aspect of this article is the dissemination of practices for transforming urban spaces and green areas in remote areas and micro-districts of the city, which require fundamental changes in spatial planning and the creation of new spaces for the leisure and recreation of local residents.
DO REAL AO MANIPULADO
Authors: Viero Daniel Mota , Rauber Luis Henrique , Barth Mauricio
Published: October 2023

This article addresses the relationship between photography and advertising, its processes in an advertising photo production, deepening studies on image manipulation and its real impacts within advertising. Considering that advertising photos are artificially manipulated, bringing a positive impact through visual aspects in ads and thus making a more attractive brand, however, it contemplates negative impacts through social behaviors that may arise from this. Therefore, this work aimed to understand how image manipulation can influence consumers. Based on an applied research methodology, an online questionnaire was developed, obtaining results by verifying that, currently, people perceive when there is manipulation, resulting in behavioral changes in society, however, they continue to consume brands that use this technique in their advertisements
Role of Aahar and Panchakarma on restoration of euglycemia in known type II diabetes mellitus
Authors: Revandkar Vaidehi , Gond Bipin , Mandole Rahul , Amin Gurudatta , Ghadigaonkar Pravin
Published: October 2023

Background: Diabetes mellitus, in particular, has emerged as a significant health concern, affecting millions of individuals and placing a considerable strain on the healthcare system. Promoting remission of diabetes, wherein patients achieve a state of sustained blood sugar control without the need for ongoing medication or with a reduced reliance on medication, can yield remarkable benefits. This study sought to understand the role of Aahar and Panchakarma on restoration of euglycemia in known type 2 diabetes patients.
Methods: A retrospective, observational, cohort study was conducted at Madhavbaug Cardiac Care Clinic between April 2021 and April 2022 in Maharashtra, India. Patients aged 18 years and older with a diagnosis of type 2 diabetes mellitus with glycated haemoglobin level (HbA1c) >7% and had participated in the Comprehensive Diabetes Care (CDC) program were included in this study. Parameters such as HbA1c, body weight, body mass index (BMI), and dependence on conventional allopathic medication were assessed at the end of the CDC program. Follow-up was conducted at 90 days. Day 1 and day 90 data were compared.
Results: Of the 45 patients, 17 (40.5%) patients had a negative glucose tolerance and 14 (33.3%) patients had impaired glucose tolerance. HbA1c, body weight, and BMI improved at the end of CDC program. Dependency on conventional allopathic medications was also reduced.
Conclusions: Restoration of euglycemia in patients with type 2 diabetes mellitus is possible, however, further studies to understand the affecting factors are warranted.
Fitz Hugh Curtis syndrome as a cause of acute abdomen: case report
Authors: Gutiérrez Carlos Durán , Rojas Andres Felipe Alvarez , Muñoz Braulio Rios
Published: October 2023

The case of a young adult woman who came to the emergency room with acute surgical abdomen is presented. As part of her treatment, laboratory studies were performed, highlighting leukocytosis at the expense of neutrophilia. An abdominal CT study with contrast was also performed, which showed free fluid in the abdominal cavity without diagnostic confirmation, so a diagnostic laparoscopy was performed where perihepatic adhesions were evident on violin strings suggestive of Fitz Hugh Curtis syndrome. Fitz Hugh Curtis syndrome is an entity little reported in the surgical literature. Its manifestations are nonspecific with generalized abdominal pain, nausea, vomiting, and fever. It is a diagnostic challenge since it can be confused with other surgical gastrointestinal pathologies such as appendicitis or cholecystitis, occurs in both genders, although it is more common in women of reproductive age, its diagnosis is usually a postoperative finding, the prognosis will depend on the postoperative findings and non-surgical management. We present a review of the literature and a reported case.
Ball valving laryngeal masses: a difficult “ball” in the anaesthetists’ court
Authors: Verma Ankur , Biswas Shubhashish , Singh Pooja , Tyagi Tarun , Khatri Pankaj , Gupta Tushar , Dabas Surender Kumar
Published: October 2023

Dynamic airway obstruction (also called ball-valve effect) is a serious condition often seen in glottic lesions. This is an anesthetic challenge as total airway obstruction can occur after the induction of general anesthesia. We present a case of a middle aged female who had a large laryngeal mass which was showing ball-valve effect. The patient had refused for tracheostomy despite it being the safest procedure in the circumstances. We then performed videolaryngoscopy and managed to intubate the patient with the help of some improvisation. The patient underwent a succesful and uneventful surgery.
A rare case of serologically diagnosed overlap syndrome presents as an idiopathic inflammatory myositis without any overlapping features
Authors: Patel Disha , Patel Darsh , Parikh Prachi , Patel Parth
Published: October 2023

Overlap syndrome is a rare inflammatory rheumatic condition that shares features suggestive of at least two distinct autoimmune diseases with a reported prevalence of less than 34/100,000 persons and an incidence of less than 20/million/year. One example of an overlap syndrome is the presence of dermatomyositis or polymyositis with other autoimmune afflictions such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), or Sjogren’s syndrome. We present a case report of a 22-year-old male presented with progressive weakness in both upper and lower limbs without any other significant complaints. On investigation, serology revealed antibodies suggestive of overlap syndrome, which on further investigations, categorized as idiopathic inflammatory myositis (IIM). This shows that overlap syndrome, as an IIM, is one of the differential diagnoses in patients presenting with progressive extremity weakness involving both extremities even if there is no involvement of any sensory function.
A qualitative study to assess dynamics of major injuries in children and adolescents of a rural area of Delhi
Authors: Banerjee Bratati
Published: October 2023

Background: Childhood injury constitutes a grave public health problem. Most of the unintentional injuries and their consequences are preventable. Present study highlights the dynamics related to major injuries in children.
Methods: This is part of a prospective research conducted over 16 months, on 397 children and adolescents of rural Delhi. Present report includes those with major injuries. Data was collected by in-depth interview of subjects with major injuries, and their guardians.
Results: Five major injuries occurred during study period. Thus incidence of major injuries was 1.26/100 children/year and proportion of major injuries out of total injury events was 2.89%. There was no fatality or disability. Socio-demographic risk score was high for 4 out of the 5 children. All subjects were adolescents, of whom 3 were boys and 2 girls. All injuries were of locomotor system, with two cases having multiple glass-cut injuries in addition. All injury events had occurred when subjects were away from home, of which three occurred on road, due to unclean surroundings in one case and two by motor vehicle accidents due to inexperienced drivers, of less than legal age for driving, and on alcohol. Treatment was taken from secondary care hospitals by all injured subjects. Mean cost of treatment was Rs.5,009/-, with total out-of-pocket expenditure being Rs.7,212/- (mean=Rs.2,404/-). Mean time to recovery was a little over 1 month (32 days).
Conclusions: All the major injuries that occurred in the study population could have been prevented by taking responsibility at various levels.