bluuebunny/crossref_metadata_2025 huggingface dataset:
Fungal endophytic species Fusariumannulatum and Fusariumsolani: identification, molecular characterization, and study of plant growth promotion properties
Authors: Biswas Soma , Sarojini Suma
Published: December 2023

Research on endophytic fungi has gained significant interest due to their potential to enhance plant growth directly by producingphytohormones, solubilizing macronutrients, fixing nitrogen, or indirectly inhibiting phytopathogens growth by producing ammonia, siderophore, hydrogen cyanide, or extracellular enzymes, thereby acting as biocontrol agents. The present study aimed to isolate fungal endophytes from Alternantheraphiloxeroidesand evaluate their plant growth promotion and antimicrobial activity. In total, nine fungal endophytic strains were isolated from different parts of A. philoxeroides such as leaves, roots, and stems. The results demonstrate that the strains MEFAphS1 and MEFAphR3 exhibited positive plant growth promotion properties,including phosphate solubilization, and IAA (Indoleacetic acid) production, and ammonia production. The IAA production was highest for MEFAphS1, with a concentration of 46.635±1.04 µg/mL, while MEFAphR3 displayed the highest ammonia production (0.903±0.01 µg/mL). The phosphate solubilization index (PSI) is the maximum for MEFAphS1 (1.5±0.10). MEFAphS1 also exhibited antibacterial activity against Vibrio vulnificus, Streptococcus pneumoniae, and V.parahaemolyticus,with the most substantial inhibition zone observed against V.vulnificus(28±1 mm). In contrast, MEFAphR3 showed an inhibition zone of 8±1.53 mm against V. parahaemolyticus. Molecular identification revealed the identity of the isolates MEFAphS1 and MEFAphR3 as Fusariumsolaniand F.annulatum. These results thus confirm the possible applications of the fungal endophytes as plant biofertilizers and bio-enhancers to increase crop productivity.
Optimizing smart manufacturing systems using digital twin
Authors: Ojstersek R. , Javernik A. , Buchmeister B.
Published: December 2023

Presented paper investigates the application of digital twins for the optimisation of intelligent manufacturing systems and focuses on the comparison between simulation modelling results and real-world production conditions. A digital twin was created in the Simio software environment using a data-driven simulation model derived from a real-world production system. Running the digital twin in real time, which was displayed graphically, facilitated the analysis of key parameters, including the number of finished products, average flow time, workstation utilization and product quality. The discrepancies were attributed to the use of random distributions of input data in the dynamic digital twin, as opposed to the long-term measurements and averages in the real-world system. Despite the limitations in the case study, the results underline the financial justification and predictive capabilities of digital twins for optimising production systems. Real-time operation enables continuous evaluation and tracking of parameters and offers high benefits for intelligent production systems. The study emphasises the importance of accurate selection of input data and warns that even small deviations can lead to inaccurate results. Finally, the paper high-lights the role of digital twins in optimising production systems and argues for careful consideration of input data. It highlights the importance of analysing real-world production systems and creating efficient simulation models as a basis for digital twin solutions. The results encourage extending the research to different types of production, from job shop to mass production, in order to obtain a comprehensive optimisation perspective.
Landscapes of Movement Along the (Pre)Historical Libyan Sea: Keys for a Socio-Ecological History
Authors: Laguna-Palma David , Barruezo-Vaquero Pablo
Published: December 2023

This study examines the influence of Human Ecodynamics and Historical Ecology to understand the complexities of historical mobility. Based on Landscape Archaeology, this study considers some of these theoretical principles for studying and reconstructing the movements of past human populations. This discussion is grounded on the example of a research project focused on modelling movement and interaction patterns between the Aegean area (Crete) and northeastern African region (Marmarica) from the Late Bronze to Roman times. The project works with multivariate data representative of the routes and non-human factors that may interplay in biocultural processes. Three key aspects structure this article: (1) the emergence of Human Ecodynamics and Historical Ecology in archaeology, (2) their impact on the theoretical evolution of Landscape Archaeology, and (3) the methodological implementation of these principles through a case study. We specifically discuss the strengths of Human Ecodynamics and Historical Ecology to enhance the conceptualisation of mobility by considering the heterarchical interrelationships between human and non-human agents. Our methodological implementations showcase this by using computational approaches to model human pathways influenced by and in constant relationship with their environment. This research thus highlights the importance of transdisciplinary approaches to studying historical mobility from an archaeological and complex systems perspective.
An overview of retinal light damage models for preclinical studies on age-related macular degeneration: identifying molecular hallmarks and therapeutic targets
Authors: Carozza Giulia , Zerti Darin , Tisi Annamaria , Ciancaglini Marco , Maccarrone Mauro , Maccarone Rita
Published: December 2023

Age-related macular degeneration (AMD) is a complex, multifactorial disease leading to progressive and irreversible retinal degeneration, whose pathogenesis has not been fully elucidated yet. Due to the complexity and to the multiple features of the disease, many efforts have been made to develop animal models which faithfully reproduce the overall AMD hallmarks or that are able to mimic the different AMD stages. In this context, light damage (LD) rodent models of AMD represent a suitable and reliable approach to mimic the different AMD forms (dry, wet and geographic atrophy) while maintaining the time-dependent progression of the disease. In this review, we comprehensively reported how the LD paradigms reproduce the main features of human AMD. We discuss the capability of these models to broaden the knowledge in AMD research, with a focus on the mechanisms and the molecular hallmarks underlying the pathogenesis of the disease. We also critically revise the remaining challenges and future directions for the use of LD models.
Das Produktionssystem von Mercedes-Benz und die Digitalisierung der Produktion
Authors: Herlyn Wilmjakob J.
Published: December 2023

Aufgrund des weltweiten Erfolges von Toyota standen um die Jahrtausendwende unternehmensweite Produktionssysteme eine Zeit lang hoch im Kurs, vor allem in der Automobilindustrie. Danach trat dieses Thema in den Hintergrund, die Aufmerksamkeit galt immer mehr der zunehmenden Digitalisierung und vor allem der Industrie 4.0, die zu großen Veränderungen vor allem im technischen Bereich führte. Inzwischen erstreckt sich deren Einfluss zunehmend auch auf die Steuerung der Produktion und des Materialflusses auf der Shopfloor-Ebene, die durch das Management Execution System (MES) gesteuert wird. Der Mercedes-Benz Group ist es gelungen, diese Themen miteinander zu verknüpfen und erfolgreich in den über dreißig Fabriken weltweit einzusetzen.
Flächenproduktivität
Authors: Schneider Markus , Müller Christoph , Schnabel Stephan
Published: December 2023

Aufgrund der gestiegenen Bedeutung von Nachhaltigkeit wird diese als strategisches Unternehmensziel immer relevanter. Bisher genutzte Kennzahlen sind jedoch für die zur Zielerreichung notwendige Operationalisierung von Nachhaltigkeit im Sinne der in der Literatur definierten Anforderungen ungeeignet. Deshalb wird in diesem Beitrag die Annahme einer neuen Hilfskennzahl, der sogenannten Flächenproduktivität, vorgestellt, die sowohl Nachhaltigkeit valide und gesamtheitlich wiedergibt als auch die weiteren Anforderungen in Form von Benutzerfreundlichkeit und Wirtschaftlichkeit erfüllt und sich damit zur Verhaltenssteuerung in Unternehmen eignet.
Gendered Perceptions of East and South Asian Men
Authors: Goh Jin X. , Trofimchuk Vlada
Published: December 2023

Gendered race theory argues that in the United States, Asian men are perceived as more feminine and less masculine than Black and White men. However, extant research has focused predominantly on East Asians while overlooking South Asians. In five studies (N = 1,773 U.S. participants), we examined the perceived femininity-masculinity of East and South Asian men. East Asian men were perceived as more feminine and less masculine than South Asian, White, and Black men. South Asian men's perceived femininity-masculinity depends on whether they have facial hair or not. South Asian men with facial hair were perceived as less feminine, more masculine, and more threatening than men from other racial groups. This hyper-masculinization of South Asian men is likely due to alignment of the bearded terrorist stereotypes with facial hair cues. Results for South and East Asian women were inconsistent. This research highlights the importance of disaggregating Asian targets in social cognition theories.
Correlation between shear bond strength and degree of conversion of four orthodontic adhesives.
Authors:   Department of Pedodontics, Orthodontics and Preventive Dentistry, College of Dentistry, Hawler Medical University, Erbil, Iraqi Kurdistan Region., Ibrahim Hangaw Tariq , Hassan Bayan Abdulla
Published: December 2023

Background and objective: The study aims to assess the correlation between degree of monomer conversion (DC) and shear bond strength (SBS) of the different adhesives. The objective of the present study was to determine the efficiency of four orthodontic adhesives regarding shear bond strength (SBS), debonding characters and degree of conversion (DC) and to correlate SBS to the DC. Methods: Forty human upper first premolars, divided into four Groups (n = 10) were bonded with metal brackets using four different adhesives. Brackets were debonded in shear on an Instron universal testing machine with a crosshead speed of 1 mm per minute. The mode of bond failure was determined by the adhesive remnant index (ARI) index and the DC was determined by Fourier transform infrared spectroscopy (FTIR) analysis. Result: There was a statistically significant difference between the SBS of only Transbond XT and Orthobond plus color change adhesive while the two remaining adhesives showed no significant difference. All groups of adhesives showed a cohesive type of bond failure according to the ARI results. A statistically significant lower percentage of DC was noted for Orthobond plus (63 %) than Transbond XT (70.2 %) but it was within the accepted range reported in the literature (55-75%). Pearson’s correlation was significantly positive between SBS and DC for Smart Ortho, Heliosit Orthodontic and Orthobond Plus adhesives and insignificantly positive for Transbond XT. Conclusion: Within the limitations of this in vitro study it can be concluded that the Transbond plus color change has significantly higher fluoride release as well as recharge properties when compared to other ortho-adhesive materials. Keywords: Orthodontic Adhesive, Shear Bond Strength, Degree of conversion
Impact of diabetes mellitus on dental implants: A cross sectional controlled clinical study.
Authors:   Directorate of health-Erbil / Oral and maxillofacial surgery department- Rizgary teaching hospital- Erbil, Iraq., Hamad-Ameen Rezhna Muhammed , Omer Othman Abu-Bakr
Published: December 2023

Background and objective: After osseointegration the long-term success of dental implants is determined by the maintenance of the peri-implant soft tissue and bone level. This study evaluates the impact of Diabetes mellitus on dental implants in diabetic patients and compare it with that of nondiabetic patients. Patients and methods: Thirty diabetic patients and thirty controlled subjects rehabilitated with dental implants were included in this study. The duration of implant treatment is (1-7) years, and dental implant status between both groups was compared using Immunohistochemistry for analyzing Interleukin 6 in peri-implant crevicular fluid, bacteriology, radiology, and clinically by measuring gingival sulcus depth, bleeding on probing, gingival recession, presence of suppuration and mobility. The statistical package for the social sciences program (SPSS, version 28) was used for data analysis. Results: Diabetic patients show a Statistically significant difference to non diabetic subjects in the level of interleukin 6 with (P value 0.004), Culture and sensitivity with (P value 0.003), Peri -implant bone loss in mesial and distal sides of the implant with P values 0.006 and 0.002 respectively, and also, in gingival recession with (P value 0.017). while the difference was not significant in gingival sulcus depth P value0.220, bleeding on probing P value0.550, implant suppuration P value 0.999, and mobility P value 0.999. Keywords: Bacteriology, Diabetes mellitus, Interleukin 6, Osseointegration, Periimplantitis
Evaluating Accessibility of Street Network in Neighborhood by Space Syntax Method: The Case of Çankırı
Authors: Körmeçli Pelin Şahin
Published: December 2023

Designing inclusive cities by creating accessible neighborhoods in cities is one of the top agendas in urban planning and design. Therefore, it is important to examine settlements morphology to find out functional contributions to urban design. In this study, the aim is to find street characteristics that support accessibility by comparing street network of current and zoning plan in the neighborhood. The study was carried out in the Esentepe Neighborhood, which is far away from the city center of Çankırı. The fact that the neighborhood is one of the directions of urban development and is located in an area with low accessibility throughout the city requires the development of this area. The study area was evaluated by the space syntax method. The study was designed in three stages. First, the spatial accessibility of the street network in the Esentepe Neighborhood in its current state was analyzed by creating axial maps. Secondly, integration and connection maps were created to evaluate the accessibility of the street network based on the future development plan of the Esentepe Neighborhood. Finally, the current and master plan of the neighborhood was compared to understand the characteristic of accessible street network in the neighborhood. The study results revealed that integration and connectivity values increased compared to the current plan. The creation of simple, interconnected and intersected axes placed in a certain range increased accessibility of area. The long and continuous central axis providing access to the circular central area and the axes connected to this line have the highest integration value in the neighborhood. Space syntax will be a guiding tool on issues such as the selection, design and development of settlements in city plans. The transportation system, which promotes use of spaces around the residence in settlements planned far from cities, contributes to the evaluation of the social interaction areas for residents. The research develops a proposal method in terms of evaluating the future development of neighborhoods for creating a sustainable transportation system.
Ostrakinda: A Game-Based Learning Toolkit for Ancient Mediterranean Cities
Authors: Heyik Muhammet Ali , Erdoğan Meral , Tong Togan
Published: December 2023

The study develops the 'Ostrakinda' toolkit for teaching morphologies of ancient Mediterranean cities. The methodology consists of a triple structure involving design, play, and analysis phases. In the design phase, the level of interest and actual demands of students regarding game-based learning (GBL) and ancient cities were explored through pre-experiments. The play phase involved experimental studies conducted in courses and workshops, where both physical and digital toolkits were tested by a total of 331 students. The analysis phase aimed to evaluate the impact of the game by systematically addressing five research questions.
The results of the paired t-test confirm a significant difference in scores before and after playing the game, thus validating the effectiveness of the proposed strategy. Additionally, Chi-square (X2) tests revealed significant relationships between the form of play and the level of abstraction in the game outputs. Individual and group experiences during gameplay were associated with various interactions, and group experiences particularly fostered competitive and collaborative learning. The extensive analysis using the GBL Design Scale, comprising ten critical factors (GBL-Fn), showed that the challenge factor (F8) had the weakest values, while fantasy (F5) and narrative (F6) had the highest values in the correlation matrix.
Overall, the study contributes methodologically and contextually to the existing literature, offering valuable findings for the future development of similar strategies in architectural education. However, it is important to acknowledge the limitations of this interdisciplinary study, particularly with regards to technical, cognitive, and archaeological aspects. Nevertheless, the clear and effective structure of the game holds promise as a valuable tool for learning.
A családi életre nevelés realitásai.
Authors: Pusztai Gabriella , Pallay Katalin , Csók Cintia
Published: December 2023

Az utóbbi évtizedekben a családi élet alapvető változásokon ment keresztül, ami
hatással van a családi és felnőtt életre nevelés alapvető mintázataira is. Az
interjús kutatás során olyan települési és iskolai környezetekben dolgozók
(N = 53) tapasztalatait tártuk fel az ország három
leghátrányosabb helyzetű megyéjében, ahol a legmagasabb az alacsony státusú
tanulók aránya. A tanulmány egyik fontos megállapítása, hogy a családokban
megvalósuló spontán családi életre nevelésben társadalmi-területi szempontból
nagy eltérések jellemzők, ezért a felnőtt élet több területére való felkészítés
kihívást jelentő iskolai feladat, mely a pedagógusok és az iskolai segítő
szakemberek speciális felkészülését és többletmunkáját igényli.
Az „objektív” tudománymetria alkalmazásának hatásai és ellenhatásai a kutatói teljesítményértékelésben, tudományterületi megközelítésben
Authors: Dani Erzsébet
Published: December 2023

Egy korábbi tanulmányban a Glänzel-mítoszok kontextusában próbáltuk értelmezni
azokat a hiteket-tévhiteket, utakat és tévutakat, melyeket a tudománymetria
„objektív mérőszámainak” összes tudományterületre történő, a területi
sajátosságokkal mit sem törődő, egységes alkalmazása generált. A közelmúltban
lezajlott egyetemi modellváltás és az oktatói teljesítményértékelés bevezetése
még inkább előtérbe helyezte a tudománymetriát, különösen pedig a
tudományterületi anomáliákat. Jelen diszkusszióban arra teszünk kísérletet, hogy
megvizsgáljuk: a Q-minősítésű folyóiratok előnyben részesítése milyen hatással
van a humán tudományok oktatóinak-kutatóinak teljesítményére; illetve, ennek
következtében hogyan szorulnak háttérbe a Magyar Tudományos Akadémia
szakosztályai által minősítettnek tekintett magyar folyóiratok; hogyan mond
ellent egymásnak a tudományos teljesítményértékelési pontrendszer és a
tudományos előmeneteli szempontrendszer; mit jelent az, hogy a magyar kutató
ezek kettős szorításában dolgozik; és ezeknek milyen hosszú távú hatásait lehet
prognosztizálni?
СИСТЕМА ТЕХНОЛОГІЙ АДРЕСНОЇ ДОСТАВКИ ЕНЕРГІЇ ДО ЕЛЕМЕНТІВ ХАРЧОВОЇ СИРОВИНИ
Authors: Бурдо Олег Григорович , Терзієв Сергій Георгійович , Сиротюк Ілля Вадимович , Молчанов Михайло Юрійович , Бурдо Алла Костянтинівна
Published: December 2023

Аналізуються глобальні прогнозні моделі розвитку людства: цикли Кондратьєва, індустріального революційного розвитку, концепція моделі «Римського клубу». Наведено шляхи виходу із сучасної кризи – конвергенція біо- нано та інформаційних технологій. Обґрунтовано пріоритетні напрямки розвитку: енергія, екологія, їжа. Обговорюються проблеми ключових процесів харчових технологій – екстрагування та дегідратації. Показано, що ефективним інструментом рішення основних проблем є електродинамічні технології. Формулюється гіпотеза можливості використання електромагнітних джерел енергії для адресної доставки енергії безпосередньо до елементів рослинної сировини для ініціювання гібридного процесу. Реалізація такого процесу може на порядки інтенсифікувати дифузійні процеси. В статті вирішується задача візуально підтвердити існування гібридного процесу, вивчити механізми його формування, отримати кількісні залежності впливу ключових факторів на енергетику та кінетику процесу. Наведено опис експериментального стенду та результати досліджень, які визначають наукову новизну роботи. Отримані дані були використані при організації процесу екстрагування в інноваційних мікрохвильових апаратах. Показано, що циркуляційні апарати мають вищу продуктивність по зрівнянню із традиційними. Цей факт є основним прикладним результатом роботи. Крім цього, наведена на принципова технологічна лінія, яка базується на системі інноваційних технологій, що розроблена на кафедрі процесів, обладнання те енергетичного менеджменту.
ЕКСПЕРИМЕНТАЛЬНЕ МОДЕЛЮВАННЯ ПРОЦЕСІВ ЕКСТРАГУВАННЯ ЕФІРНИХ ОЛІЙ У МІКРОХВИЛЬОВОМУ ПОЛІ
Authors: Коваленко Олег Анатолійович , Славинський Руслан Леонiдович , Федосов Яків Сергійович , Славинська Вікторія Олександрiвна , Аль-Хамад Ілля Малекович
Published: December 2023

Тенденції зростання світового ринку ефірних олій та попит на натуральні речовини є драйверами поширення використання ефірних олій в різноманітних галузях народного господарства. Існує багато методів отримання ефірних олій, у статті описані і порівняні традиційні та інноваційні методи, які уповільнюють ризик втрати основних термолабільних компонентів рослинної сировини, зберігають якість, зменшують час екстракції, діють екологічно безпечно та збільшують відсоток виходу ефірних олій. У зв'язку з тим, що традиційні методи отримання ефірних олій мають багато недоліків основний з яких — це термостабільність ефірних олій за високих температур існує необхідність у інноваційних методах, які зменшать вплив цих факторів.
В статті приведені експериментальні данні дослідів на різних зразках квітів лаванди та гісопу сорту «Маркіз».  Проілюстрован експериментальний стенд для проведення екстракції ефірної олії з лаванди та гісопу за допомогою інноваційного методу — мікрохвильової дистиляції парою.
Цей процес є поєднанням традиційних технологій, а саме, парової дистиляції та інноваційної технології, мікрохвильового нагріву. Нагрівання мікрохвилями допомогло ініціювати та створити передачу маси та тепла в середині рослинних матриць назовні, що призвело до значного скорочення часу екстракції, за допомогою впливу механодифузії. На підставі аналізу методів та на основі експериментальних даних робимо висновок про те, що електродинамічні системи мають значні перспективи у широкому використанні. Тому, ставиться завдання залучити їх до процесів отримання екстрактів ефірних олій. Проведено дослідження кінетики екстракції та вплив гідромодуля на процес екстрагування. Визначено, що циклічне екстрагування вилучає більше цільових компонентів, ніж одноразове.
Вплив гідромодуля на інтенсивність масоперенесення характеризує науково-технічне протиріччя між факторами підвищення значення рушійної сили та концентрацією екстракту. Розглянуто вплив схеми обробки на інтенсивність масоперенесення на прикладі гісопу сорту «Маркіз». Отримані результати є базою для організації  енергоефективних режимів екстрагування із квітів лаванди та гісопу.
ФОРМАЛІЗАЦІЯ ПРОЦЕСУ ПЕРЕРОБКИ СИРОВИННИХ ПОТОКІВ КОВБАСНОГО ВИРОБНИЦТВА
Authors: Ощипок Ігор Миколайович
Published: December 2023

В статті розглянуто питання розробки процесу формалізації надходження м’ясної сировини на переробку при виготовленні ковбасних виробів. Оскільки м’ясо — перш за все, основне джерело тваринного білка завдяки своїм багатством незамінних амінокислот, що відносить його до повноцінних білків, важливо в технології його переробки зберегти притаманні  йому властивості. найбільше в Європейській частині споживається свинячого м’яса і яловичини, менше овець. завдяки високому виходу туші, вважається, що тварини відіграють важливу роль у виробництві м'яса в країні. Наявність значної кількості води в м’ясі, високої біологічної цінності білків робить його цінною сировиною для збалансованого харчування. Щоб забезпечити ефективність процесу переробки в сучасних умовах різного за своїм походженням, фізико-хімічними властивостями м’ясної сировини, слід застосовувати методи з комп'ютерним моделюванням та розробленням належного забезпечення програмами. В процесі розроблення програмних продуктів, які щільно пов'язані з областю управління проєктами, отримане програмне забезпечення вважається оригінальним результатом. організація цього процесу впливає на основні показники передбачені в проєкті - строки виконання, розрахований бюджет, якість розробки. Але вміле управління проєктами не може гарантувати досягнення зазначених показників. Значну роль у цьому відіграє архітектура розроблених програм, досвід і кваліфікація членів команди яка приймала участь в розробці, а також регулярну фіксацію всіх етапів в процесі розробки таких програм. Тут враховані різні українські та міжнародні стандарти, що регламентують організацію процесу розробки, документування окремих послідовних етапів призначених для застосування фахівцями і дослідниками з розробки і проєктування комп'ютерних моделей і програмного забезпечення виготовлення коибасних виробів. Ще один тип знань, якого так не вистачає сьогодні на підприємствах, стосується кінетики явищ, і зокрема їх залежності від умов виробництва (температури, активності вода, рН тощо). Однак кінетика є важливою інформацією для високоефективного ведення процесу переробки яку важливо враховувати. Запропоновано ефективність ковбасного виробництва досягти шляхом формалізації потоку різної м’ясної сировини за допомогою методів математичного програмування і застосуванням комп’ютерних технологій з врахуванням нестабільної якості використовуваної м'ясної сировини при виробництві ковбасних виробів.
Artificial Intelligence (AI) for Research Lifecycle: Challenges and Opportunities
Authors: YAROSHENKO T. O. , IAROSHENKO O. I.
Published: December 2023

Objective. This article aims to review the progress of AI technologies concerning their potential impact on academia, research processes, scientific communication, and libraries. Methods. AI  tools for research lifecycle and their potential impact on academia and libraries were identified from various sources, mostly from the most influential recent scientific publications. Results. AI has become a driving force nowadays, creating both opportunities and challenges. Transformative AI-powered tools, exemplified by advanced models like ChatGPT, Llama-2, Google Bard, Microsoft Bing, and Jasper Chat, among others, find versatile utility across a broad spectrum of contexts, extending their impact to research process and publishing, as well as to librarianship. The enthusiastic embrace of AI in research is tempered by a pervasive concern over the potential for data fabrication, which can significantly compromise ethical standards and academic integrity. There is an urgent need to understand corresponding opportunities, challenges, and dangers. Some aspects of the use of AI tools for different stages of the research lifecycle are considered, and the main advantages and risks are analyzed. Conclusions. AI  has the potential to drive innovation and progress in a wide range of fields and possesses significant potential to propel academia and librarianship into both exhilarating and challenging new frontiers. While AI-powered tools represent major advancements and potential to significantly impact academia,  scholarly research, publishing, and university libraries. Privacy and bias are just two examples of the ethical considerations that need to be made.
A compromise based adaptation strategy for business structure management in crisis
Authors:   Plekhanov Russian University of Economics (Perm Branch), Oborin Matvey S. ,   Perm State University,   Perm State Agro-Technological University
Published: December 2023

Introduction. The current macroeconomic instability contributes to the development of scientific and theoretical foundations for the notion of business structure adaptation to external challenges. An entity of economic activity should be considered both as an element of a multi-faceted regional and industry production system and as a relatively isolated structure with its own organizational behavior and associations with other various entities. Business structure adaptation means behavioral changes determined by the ongoing qualitative systemic changes that significantly affect the key performance parameters. Purpose. The purpose of the study is to develop the conceptual framework for a compromise based adaptation strategy. Materials and Methods. Methodologically, the study refers to scientific and theoretical approaches to management adaptation for regional economic systems and business structures. Modeling of economic and managerial processes and statistics analysis are the key methods of this study. Rosstat’s official data was used as the information database for the study. Results. The paper describes various types of government support in large cities. These measures were aimed at reducing the number of closed down small and medium-sized companies and compensating for the damage they suffered. The study also looked at the factors and conditions that specify the interaction of large and small businesses in the regional economic system, as well as the features of their organizational behavior in regulating financial and economic obligations with the authorities. Conclusion. The research is academically novel in the development of the notion of a compromise based adaptation strategy for business structures in crisis, taking into account the trends in organizational behavior of large, small and medium-sized businesses, authorities, and industry management, which are being driven by joint activities typical for the current events in Russia.
812.1 Lung FFPE OMAP Multiplexed Immunofluorescence Phenocycler-Fusion® Antibody Validation Protocol v1
Authors: Purkerson Jeffrey , S Pryhuber Gloria , Huyck Heidie , not provided gail.deutsch
Published: December 2023

This protocol describes validation of a 34-antibody panel used for multiplexed immunofluorescent (MxF) staining and imaging of FFPE lung tissue sections utilizing the Phenocycler-Fusion® platform (Akoya Biosciences). The validation strategy involves staining two serial lung sections, one with cocktail of custom barcode-conjugated antibodies plus antibody-barcoded conjugates sourced from Akoya Biosciences and the second with the respective unconjugated, carrier-free control antibodies and omitting the Akoya antibodies. In addition, a tonsil section was exposed to the all-conjugated antibody cocktail to confirm specificity of antibodies directed against lung specific markers, and specificity of pan-epithelial, endothelial, megakaryocyte, and immune cell markers in 2 different tissues (e.g. lung, tonsil). The protocol includes sections describing 1) Tissue sections, 2) Labeling with barcode-conjugated or unconjugated Ab, 3) Reporter Plate and Experimental Design, 4) Multiplexed Imaging and Image Upload to OMERO for review, and 5) Review criteria. Detailed descriptions of staining and imaging procedures can be found in a companion protocol dx.doi.org/10.17504/protocols.io.6qpvr38dpvmk/v2.
Characterization and potential use of olive pies from different extractions and industries in ruminant feeding
Authors: Rizzo F. A. , Schafhäuser Jr. J. , Fluck A. C. , Scheibler R. B. , Nörnberg J. L. , Vargas D. P. , Costa O. A. D. , Lourenço L. A. , Suzin G. O.
Published: December 2023

This work aimed to characterize coproducts from extra virgin olive oil extraction, its chemical composition and nutritive value of two olive cultivars (Arbequina and Koroneiki) in industries in Brazil Southern region. Sampling from cultivar Arbequina was done at two moments (time 0 and 48h post processing) and from cultivar Koroneiki, only at time zero was sampled.  The composition of the two cultivars was different, as expected. Higher levels of carbohydrates (CHO) and lower levels of neutral detergent fiber (NDF) contributed to improve in situ degradability (61.0 vs 43.5% ) of  Koroneiki cultivar. Both co-products obtained on the day of processing showed high levels of lignin, which led to a lower level of in situ degradability of the NDF (21.1%). High levels of EE (19.4% DM), total phenols (FT; 1.8% DM), total tannins (TT; 1.11% DM) and TDN (72.7% DM) were also observed. These results demonstrate that the byproduct represents a potential source of lipids and phenolic compounds that can be used to adjust diets as well as the aggregation of functional molecules in meat and milk products. The care in obtaining and preserving the product is important because the material obtained 48 hours after the processing showed losses in the contents of CHO, CNF, FT and TT, which can impair its nutritional value and the potential of use.
Internet of Things (IoT) Based Air Conditioner Monitoring System for Intelligent Facility Maintenance
Authors:   Department of Mechanical and Manufacturing Engineering,  Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Zheng Yew Yap , Md Saad Mohamad Hanif ,   Department of Mechanical and Manufacturing Engineering,  Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Sahrani Shafrida ,   Institute of IR4.0 (IIR4.0), Universiti Kebangsaan Malaysia, Malaysia, Habib Kaiser ,   Department Electrical, Electronic and Systems Engineering, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia, Hussain Aini ,   Department Electrical, Electronic and Systems Engineering,  Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Malaysia
Published: December 2023

Office buildings often consume high energy to sustain building operations such as HVAC systems. A lack of proper decision-making approaches and a lack of maintenance planning will cause higher operational costs. This paper proposes data analytics for air conditioner’s performance in laboratory by using Internet of Things (IoT)-based monitoring system to improve efficiency in facility maintenance. It provides a monitoring system, notification system and performance dashboard to enable data analytics. The data analytics methods used here are i) condition-based maintenance which includes thermal analysis and electrical analysis; and ii) Overall Equipment Effectiveness (OEE) approach. The pre-maintenance performance measured for AC-1 is adequate while AC-2 does not meet the requirement. After the reactive maintenance was performed on AC-2; there was a performance increment of 63.15%. Based on sensors data, it seems to correlate between current draw and low refrigerant. It aids facility maintenance for early failure detection, which helps in decision-making. The result from the OEE approach also suggested the same decision-making to schedule maintenance. Performance needs to balance out to leverage power consumption without hefty operational costs for maintenance strategies. In conclusion, the data analytics provide insight for the maintenance management to monitor and schedule preventive maintenance before air conditioner (AC) faults happen. Meanwhile, the modified OEE approach for ACs to measure performance takes into consideration speed to cool down air and cost to run the AC which has not been explored yet elsewhere.
Examining Large-Scale Solar (LSS) Photovoltaic (PV) Operating Utilities by using Environmental Impact Screening (EIS)
Authors:   Civil Engineering Studies, College of Engineering, Universiti Teknologi MARA, Cawangan Pulau Pinang, Permatang Pauh  Campus, Malaysia, Hani Ismail Siti Isma , Mohd Norman Nur Syaza Syazwiena ,   Civil Engineering Studies, College of Engineering, Universiti Teknologi MARA, Cawangan Pulau Pinang, Permatang Pauh  Campus, Malaysia, Md Nor Noorsuhada ,   Civil Engineering Studies, College of Engineering, Universiti Teknologi MARA, Cawangan Pulau Pinang, Permatang Pauh  Campus, Malaysia, Zakaria Zulfairul ,   Civil Engineering Studies, College of Engineering, Universiti Teknologi MARA, Cawangan Pulau Pinang, Permatang Pauh  Campus, Malaysia, Hassan Siti Hafizan
Published: December 2023

For Malaysia’s future energy needs, solar photovoltaic (PV) technology and farming is becoming a more costeffective option and technology in achieving Malaysia’s goal of having 31% renewable energy in its power mix by year 2025. Malaysia’s global climate commitment is to reduce its economy-wide carbon intensity (as a percentage of GDP) by 45% by 2030 compared to 2005 levels. Realizing the government’s vision is critical to assisting the country in meeting its Nationally Determined Contributions (NDC) targets (SEDA, 2022). Hence, this paper highlights the evaluation of an existing solar farm located at Seberang Perai Pulau Pinang, Malaysia as a case study to examine the potential environmental impact arising from of large-scale solar (LSS) PV development utilising the Analytic Hierarchy Process (AHP) under the Multi-Criteria Decision Making (MCDM) technique. The approach for this study was conducting in depth interviews with 16 people, including academics, authorities, and experts in the field. Large projects need to be evaluated to make sure that any potential problems are found and resolved early in the planning and design phases. This study considers the effects on the environment and chemicals (EC), as well as occupational safety (OSH) and economic impact (EI). AHP is then used to assess the data and utilized to produce the final component rankings. By showing the outcomes, the bar chart will aid in improved decision-making. The bar chart’s ability to display the results will help in the decision-making. From the results, LSS PV farm were conducive to achieving strong sustainability however in term of environmental degradation, mitigation action must be implemented on site to tackle the arising issues.
Determining Efficiency of 15 OECD Countries Coping with Covid-19 using Data Envelopment Analysis after 2 Years of Pandemic
Authors: Polat Esra
Published: December 2023

Covid-19, emerged in Wuhan, a city of China, at the date of December 2019, it spread to the entire world soon and then by the World Health Organization (WHO) accepted as a pandemic. Today, still the coping with Covid-19 is the one of the significant topics of countries. In this study, the relative efficiencies of 15 OECD countries for coping with the pandemic is analyzed with Data Envelopment Analysis (DEA). Current health expenditure (% of GDP), Nurses and midwives (per 1 thousand people), Hospital beds (per 1 thousand people), Physicians (per 1 thousand people) variables used as inputs; Number of Total Cases (per 1 million people), Number of Deaths (per 1 million people) and Number of Tests (per 1 million people) variables used as outputs. Output oriented Charnes, Cooper and Rhodes (CCR) and Banker, Charnes and Cooper (BCC) DEA models are used, scale efficiency values are determined and potential improvement suggestions are given for inefficient countries. Austria, Mexico, South Korea, Spain and Türkiye are found to be both relative technical, total and scale efficient. It is also concluded that inefficient countries must use their input variables efficiently and number of Covid-19 tests is important for a country’s efficiency against Covid-19.
Simultaneously HPLC Analysis of B1, B9 and B12 Vitamins at Trace Levels via Cloud Point Extraction
Authors: Ulusoy Halil İbrahim , Yiğit İpek Nur , Polat Ümmügülsüm , Durgun Esra , Gürbüzer Aslıhan , Ulusoy Songül
Published: December 2023

An enrichment and determination method based on liquid chromatographically analysis and cloud point extraction (CPE) has been developed for trace levels of B vitamins (B1, B9 and B12) in the proposed study. Vitamin molecules were drawn into the non-ionic surfactant phase of Polyethylene Glycol (PEG-6000) in the presence of pH 9.0 medium. The surfactant-rich phase separated by centrifugation and then dissolved with 700 µL of ethanol. The obtained ethanol phase was filtered by 0.45-micron filter prior to the HPLC analysis. All parameters affecting the CPE method such as pH, buffer volume, incubation time, surfactant and electrolyte concentration, solvent for the surfactant-rich phase and its amount have been individually studied and optimized step by step. After the optimization of all parameters of the CPE process, the detection limits of the developed method for B1, B9 and B12 vitamins were calculated as 1.42 ng mL-1, 7.14 ng mL-1 and 14.28 ng mL-1 , respectively. The linear working ranges for three vitamin molecules was obtained in the range of 5.0-500.0 ng mL-1. After CPE procedure, determination of vitamin molecules was carried out by using HPLC system with diode array detector(DAD) at 244 nm for vitamin B1, 285 nm for vitamin B9, and 361 nm for vitamin B12, respectively
Evaluation of the Antitumor Activity of Omipalisib, a PI3K/AKT/MTOR Pathway Inhibitor, on Burkitt Lymphoma Cell Line
Authors: Keskin Zekeriya , Yulak Fatih , Terzi Hatice , İnanır Merve
Published: December 2023

There are many challenges in the treatment of Burkitt lymphoma, especially in immunocompromised individuals, elderly patients, and patients with relapsed or refractory disease. Therefore, there is a need for new and less toxic therapeutic agents. The aim of this study was to determine the antitumoral activity of omipalisib, a PI3K/AKT/mTOR pathway inhibitor, in the Burkitt lymphoma. Raji cell line was used in the study. Omipalisib was administered to the cell line and then the cytotoxic effect of omipalisib on Raji cells was evaluated by the XTT test. The IC50 value was calculated according to the results of the XTT test. Apoptosis and cell cycle experiments were studied with the calculated IC50 value. The flow cytometric method was used to determine the effect of omipalisib on apoptosis and cell death. The results of the study showed a statistically significant cytotoxic effect of increasing concentrations of omipalisib on Raji cells. The apoptosis experiment performed revealed that omipalisib strongly induced apoptosis. The cell cycle experiment showed that omipalisib stimulated the cell cycle arrest at the G0/G1 phase. It was concluded that omipalisib exhibited antitumoral activity on Burkitt lymphoma cells with its cytotoxic effect and induced apoptosis and cell cycle arrest. Considering this effect, targeting the PI3K/AKT/mTOR pathway with omipalisib can be a new treatment option.
Study on Electrical, Thermal, Magnetic Properties and Microstructure for - Al, -Al2Cu, ω-Al7Cu2Fe Phases in Al-32.5 wt. % Cu-1 wt. % Fe Ternary Alloy
Authors: Alper Billur Canan , Saatçi Buket
Published: December 2023

The electrical properties of the Al-32.5 wt. % Cu-1 wt. % Fe ternary alloy were examined, it was observed that the electrical resistivity increased depending on the temperature and it was found as 6.8546x10-8 Ωm - 5.7780x10-7Ωm in the temperature range of 298-810K. The thermal conductivity was calculated using electrical measurement results and it was observed that it decreased depending on the temperature. The ternary alloy (cubic -Al, Fm-3m, 225 a = 4.0480 Å, -tetragonal Al2Cu, I4mcm, 140, a=6.0654 Å c=4.8732 Å, ω-tetragonal Al7Cu2Fe, P4 /mnc, 128, a = 6.3360 Å, m and c = 14.87 Å) phases were obtained. In this ternary alloy, phases were clearly seen in XRD studies and EDAX analyzes at room temperature. Magnetic properties such as magnetic transition temperature and magnetization curves of the alloy were determined.
Osteonecrosis of the Femoral Head: Another Legacy of COVID-19?
Authors: Myasoedov Alexey A. , Shubnyakov Igor I. , Sereda Andrei P. , Karelkin Vitaliy V. , Yunkina Elizaveta A. , Berezin Georgiy V.
Published: December 2023

Background. Recovery from COVID-19 does not always proceed without complications, especially in patients who have suffered severe forms of the disease. Most researchers confirm a significant increase in the incidence of osteonecrosis of the femoral head (ONFH) after COVID-19. However, there is no clear opinion on the individual aspects of the development and course of the disease. This is an extremely important issue that allows us to identify the main risk groups for the development of post-COVID-19 osteonecrosis and, consequently, to perform the earliest possible screening of this complication.
Aims of the study: 1) To evaluate the impact of the past COVID-19 on epidemiologic parameters and clinical course of osteonecrosis of the femoral head in patients; 2) to study the causes of its development.
Methods. We have analyzed the data of medical histories of 674 patients diagnosed with osteonecrosis of the femoral head who sought medical care in 2018 and in 2022. Patients were divided into 4 groups according to the presumed causes of development of the disease. The first group enrolled 183 patients who underwent COVID-19 and received steroid therapy (ST). The second group included 78 patients who underwent COVID-19 without ST therapy. The third group consisted of 103 patients with ONFH that manifested in 2022 without COVID-19 in the previous medical history. The comparison group was made up of 310 patients who developed ONFH in 2018 before the appearance of the SARS-CoV-2 virus.
Results. The sample of patients with COVID-19-associated osteonecrosis differed significantly from patients without COVID-19, in terms of gender, age, time of disease onset, extent of the femoral head damage, and disease progression rate (p0.001). The level of early ONFH diagnosis was extremely low, not differing from that in the pre-pandemic period.
Conclusion. The COVID-19 pandemic has increased the incidence of ONFH, significantly modifying both its epidemiology and clinical picture. Nevertheless, the vigilance of practitioners remains extremely low, which affects the timely diagnosis of the disease.