bluuebunny/crossref_metadata_2025 huggingface dataset:
Fahrrad und öffentlichen Verkehr gemeinsam denken
Authors: Blechschmidt Andreas , Czowalla Lucas , Lanzendorf Martin
Published: November 2022

Die Förderung von Fahrradmobilität und öffentlichem Verkehr ist ein wesentlicher Baustein zur Gestaltung einer ökologisch nachhaltigeren, sozial verträglicheren und ökonomisch tragfähigen Verkehrs- und Siedlungsentwicklung in Deutschland. Mit einer verbesserten intermodalen Verknüpfung werden beide Verkehrsträger attraktiver und somit häufiger genutzt. Öffentliche Verkehrsunternehmen gewinnen dadurch vergrößerte Einzugsbereiche von Haltestellen, können Spitzenbelastungen abfedern und verbessern ihr Image. Fahrradfahrenden ermöglicht die Kombination mit öffentlichen Verkehrsmitteln größere Reichweiten, was gerade auch in randstädtischen, suburbanen oder ländlichen Regionen bedeutsam werden kann. Letztlich leistet die Verknüpfung der beiden Verkehrsträger einen Beitrag zur Daseinsvorsorge und für den Klimaschutz. Der Handlungsleitfaden wurde innerhalb des Forschungsprojektes „Verbesserte Integration des Fahrrads in den öffentlichen Verkehr – Systematische Erschließung von Handlungsoptionen und Bewertung von Best-Practices“ erarbeitet. Das Projekt wurde vom Bundesministerium für Verkehr und digitale Infrastruktur (BMVI) aus Mitteln zur Umsetzung des Nationalen Radverkehrsplans gefördert.
Methodenbericht zur Beschäftigtenbefragung der Goethe-Universität Frankfurt am Main zum hessischen Landesticket
Authors: Klinner Nora
Published: November 2022

Seit dem 1. Januar 2018 erhalten alle aktiven Beamt*innen, Richter*innen, Tarifbeschäftigte und Auszubildende des Landes Hessen eine Freifahrtberechtigung, sodass sie den öffentlichen Personennah- und Regionalverkehr im gesamten Bundesland kostenlos nutzen können. Diese Umstellung stellt den aktuellen Anlass für eine Fallstudie zum Thema Verkehrshandeln am Beispiel der Beschäftigten der Goethe-Universität Frankfurt a.M. dar. Im Frühjahr 2019 wurde eine quantitative Online-Befragung an der Goethe-Universität durchgeführt (n=1686). Als Grundlage und Vergleichsdatensatz diente eine Studie, die im Jahr 2015 an der Gothe-Universität durchgeführt worden ist. Ziel der Befragung war es, Informationen über die Verkehrsmittelnutzung sowie die Einstellungen zu unterschiedlichen Mobilitätsangeboten zu erhalten. Der Schwerpunkt der Befragung lag dabei auf der Nutzung des hessischen Landestickets. Das folgende Arbeitspapier befasst sich mit der Methodik der Online-Befragung und dokumentiert das Vorgehen von der Fragebogenerstellung, die Stichprobenauswahl, über die Durchführung bis zur Datenaufbereitung und reflektiert die Repräsentativität der Daten.
Does the Sustainable Urban Mobility Plan (SUMP) of the European Union guarantee successful citizen participation?
Authors: Kolb Eugenia
Published: November 2022

The Sustainable Urban Mobility Plan (SUMP) is a concept of the European Union. The non-binding guidelines formulated within this framework aim to help municipalities and cities to strategically define a local and long term transport and mobility plan. From the European Union's point of view, citizen participation plays a pivotal role during all phases – from the development of the plan until its implementation. This intends to achieve greater support and acceptance from the community for the plan, and to facilitate its implementation. This paper investigates whether the planning and political SUMP approach guarantees successful participatory processes, and what conclusions can be drawn to amend the SUMP process and general transport planning practice. It discusses how citizen participation is defined in the SUMP guidelines and how these elements are reflected in the SUMP guidelines of 2013 and 2019. In a second step, this paper shows how successful citizen participation is defined in an academic context and to what extent the SUMP reflects these findings. The findings derived from the academic context are then applied to the case studies of Ghent and Limburg in order to evaluate how successfully participation procedures were implemented in these SUMP processes. Finally, the question - what conclusions can be drawn from this to improve the SUMP process and general transport planning practice - is assessed.
Water reservoirs and the war in Ukraine: environmental problems
Authors: Ladyka Maryna , Starodubtsev Vladimir
Published: November 2022

The aim of this article is to analyze the consequences of the military invasion of the Russian Federation on February 24, 2022 on the water bodies of Ukraine. In particular, this article presents an analysis of the consequences of military operations on reservoirs.

In order to prevent the enemy from reaching the dam of the Kyiv Reservoir and to protect Kyiv from the aggressor in late February-early March of this year, the sluice of the pumping station on the Kozarovychi Dam was blown up. Because, the possible destruction of this dam could have enormous destructive consequences for the entire cascade of reservoirs and the territories adjacent to them. As a result, a huge area of about 2,500 hectares of the Irpin’ floodplain was flooded, fundamentally changing both the military and the environmental situation.

Also, Russian troops launched a missile attack on the dam of the Karachuniv Reservoir near the Kryvyi Rih city. The water level in the Ingulets River rose sharply by 2 meters, flooding the territories near the river, including part of the Kryvyi Rih city. The ecological condition of this territory was significantly damaged, private buildings were heavily flooded. Water quality in this river has deteriorated, the content of nitrogen and other elements has increased in it. The Oskol Reservoir in the east of Ukraine was also destroyed. As a result of the leakage of a significant amount of water, the muddy bottom has been exposed to water and is subject to wind erosion. The hydrological regime of the coastal area has changed. Rare species of flora and young fish population have been lost.

Destruction of reservoirs and damage to the environment will continue until the war ends. And it is necessary to do everything possible so that it ends as soon as possible
Effects of taro paste on physicochemical properties and nutritional components of bran pork sausage
Authors: Kryzhska Tanya , Shang Fei Fei
Published: November 2022

The research of adding plant materials to sausage is more popular. Taro paste is the plant raw material obtained by mashing taro after cooking. It contains rich small granules of starch, dietary fiber, and sweetened drinks are widely added. The natural flavor and the quality of glutinous taro paste are its unique characteristics. In this study, different proportions of taro paste were added to the pork sausage containing bran instead of starch, and the substitution amount was 0 %, 20 %, 40 %, 60 %, 80 %, and 100 % respectively. It is expected to improve the tissue structure, sensory quality, and nutritional composition of the sausage. This study analyzed cooking loss, emulsion stability, color, texture characteristics, moisture, sensory changes, and nutrient composition. The results showed that compared with the control group, the cooking loss, water loss and fat loss decreased significantly, and the brightness (L * value) of sausage increases, the yellowness (b * value) shows an unsTable fluctuation of decreasing and increasing, and the redness (a * value) has no obvious change; The hardness and viscosity of the sausages were significantly reduced, but the elasticity and resilience were not significantly altered; The relaxation time is shortened, and the internal semi bound moisture content is increased; Sensory evaluation results showed that all treatment groups achieved the best scores in terms of overall accepTable levels, especially for sausages with taro instead of 40 % starch; Protein, ash, water content and pH also gradually increased, while fat content decreased. By comprehensive comparison, the quality of the sausages is best when the amount of taro paste is 40 %
Algorithm for early diagnosis of hepatocellular carcinoma based on gene pair similarity
Authors: Jabrayilova Zarifa , Garayeva Lala
Published: November 2022

The article proposes an algorithm based on intelligent methods for the early diagnosis of hepatocellular carcinoma (HCC), known as liver cancer, which is rated third cause of cancer deaths in the world. Initial diagnosis of HСC is based on laboratory studies, computer tomography and X-ray examination. However, in some cases, identifying cancerous tissues as similar non-cancerous tissues (cirrhotic tissues and normal tissues) made it necessary to perform gene analysis for the diagnosis. To predict HCC based on such numerous, diverse and heterogeneous unstructured data, preference is given to the method of artificial intelligence, i.e., machine learning. It shows the possibility of applying machine learning methods to solve the problem of accurate identification of HCC due to the compatibility of HCC tissues with identical CwoHCC non-cancerous tissues. The technology of gene pair profiling using relevant peer databases is described and the Within-Sample Relative Expression Orderings (REO) technique is used to determine the gene pair’s similarity. The article also presents a new approach based on The Within-Sample Relative Expression Orderings technique for determining the gene pair’s similarity, Incremental feature selection method for feature selection, and Support Vector Machine methods for gene pair classification. The proposed approach constitutes the methodological basis of a decision support system for the early diagnosis of HCC, and the development of such a system may be beneficial for physician decision support in the relevant field
A conceptual model of the data ecosystem formation in the health 4.0
Authors: Mammadovа Masuma , Ahmadova Aytan Adil
Published: November 2022

Digitalization of health and medicine has become a global trend in recent years. The development of this trend is manifested in improving the quality of medical care, increasing access to medical services, and ensuring more effective health decisions. The global health trend is characterized by the transition from e-health to digital health, which is closely related to the formation and development of Industry 4.0. The projection of innovative approaches of Industry 4.0 into the health sector opens up great opportunities for creating a new healthcare paradigm (Health 4.0) by integrating modern technologies, analytical tools and smart medical devices.

This article highlights Industry 4.0 technologies, the integration of which into healthcare has led to the generation of a huge amount of various data. Data collected through new technologies on the Health 4.0 platform, their types, structure, sources and capabilities are examined. It is shown that for the collection, transmission, storage, processing of heterogeneous data of a large volume, the introduction of new approaches and methods is required. In the environment of technological transformation, the evolution of the healthcare system at the data level and the conceptual model of the chain of formation of the Healthcare 4.0 ecosystem are proposed. The content of the components included in the Healthcare 4.0 data ecosystem is determined. Some problems arising in the formation of the data ecosystem on the Healthcare 4.0 platform and the processing of large health data are studied
Scanning electron microscopy and X-ray microanalysis of the condition of concrete structures of a chemical enterprise with long-term corrosion in a sulfate environment
Authors: Ivchenko Viktoriia , Shkromada Oksana , Shvets Olha
Published: November 2022

Long-term operation of premises in aggressive environments of chemical enterprises affects the surfaces of concrete structures and leads to the formation of destructive processes.

The aim of the study was to determine changes in the structure and mineral composition of concrete during long-term operation in an aggressive sulfate environment at a chemical plant for the production of titanium dioxide using the sulfate method to predict the service life of concrete structures.

It has been established that during the production of TiO2 pigment by the sulfate method, the ore is decomposed by sulfate acid at high temperature, accompanied by the release of H2SO4 vapor, sulfur dioxide SO2, hydrogen sulfide H2S and elemental sulfur. Studies have established that sulfate corrosion leads to the formation of sulfur and iron oxides on the concrete surface. Studies have revealed vast areas of the surface covered with crystals of elemental sulfur, the contents of which are confirmed by the results of X-ray microanalysis. The sizes of sulfur crystals in the image range from 12 to 180 µm, the shape corresponds to the rhombic allotropic modification S8. The penetration depth of iron sulfates into the thickness of concrete is about 50 microns. The microstructure of the surface is loose, with signs of corrosion.

Exposure to a high concentration of sulphate acid vapors in the workshop of the enterprise led to the destruction of calcium carbonate and the formation of gypsum crystals in concrete. The formation of gypsum crystalline hydrates provokes sulfate corrosion of concrete, resulting in the formation of pores and microcracks in concrete with the formation of calcium hydrosulfoaluminate.

The studies carried out using scanning electron microscopy and X-ray microanalysis make it possible to investigate the structural changes and mineral composition of concrete under the influence of long-term sulfate corrosion.
PREDICTORS OF LYMPHNODE METASTASIS IN SQAUMOUS CELL CARCINOMA TONGUE
Authors: Ayyappa Morla N.S , Arumulla Jahnavi
Published: November 2022

Back Ground:The most important prognostic factor for squamous cell carcinoma (SCC) of oral is the status of cervical lymph nodes. Cure rates drop by 50% with involvement of regional lymph nodes. Cure rates drop by 50% with involvement of regional lymph nodes.The rate of occult metastasis in clinically negative neck for oral tongue cancers ranges from <20% to >30% depending on many predictors. Methods:The relationship clinical and histologic features of the primary tumor of tongue and metastasis to neck nodes was investigated in 90 patients. Results:Histopathologic features of primary tumor showed significant differences in relation to metastasis to neck nodes Conclusion:Tumor stage ,grade. vascular and perineural invasion,morphology ,tumor thickness are important predictors in predicting metastasis to neck nodes.
DISTRIBUTION OF SCHISTOSOMIASIS IN THE DEPARTMENT OF AGBOVILLE IN SOUTH-EASTERN COTE D IVOIRE
Authors: Aya Nicaise Sp. Okoubo NGuessan , Konan Claude Sylvain Yoboue , Nana Rose Sp. NGoran Diakite , Niangoran Mathieu Orsot
Published: November 2022

Bilharzia and intestinal worms are public health problems in Cote dIvoire. The health authorities are trying to control these diseases. However, it is difficult to identify outbreaks. This study was therefore initiated for this purpose. The objective was to assess the prevalence of these parasites, to map outbreaks of bilharzia and to determine the nature of the biotopes in which these diseases develop. The study was carried out in the department of Agboville. It consisted of researching high-risk households by means of a questionnaire. Parasitological examinations of urine by filtration and of stools by Kato-katz were carried out on 50 pupils per school per locality in 30 localities to find out the real prevalence of the outbreaks. A questionnaire was used to detect the nature of potential transmission sites.A total of 16.740 pupils were interviewed. Of these, 4.377 reported having urinary bilharzia and 5.542 reported blood in the urine. The urine of 1.503 pupils were examined, 26.2% of pupils had Schistosoma haematobium and 40% of the schools were hyperendemic. Schools with moderate or low prevalence were less than 10. 3.084 reported intestinal bilharzia compared to 4.361 cases of blood in the stool. A total of 693 pupils had at least one parasite. The pupils were infected with five different intestinal parasites. Both urinary (26.16%) and intestinal (15.01%) bilharziasis were very important in the department, rivers and marigots were the most at risk environments as they were present in 61.5% of the localities with hyperendemic foci.
A DESCRIPTIVE STUDY TO ASSESS THE KNOWLEDGE AND PRACTICE REGARDING SELF-MEDICATION AMONG PATIENTS VISITING OUTPATIENT DEPARTMENT IN A SELECTED HOSPITAL OF DELHI
Authors:   Registered Nurse, Dr. RML Hospital, Delhi., Mill Suparna , P. Joseph Sheeba ,   Professor, St. Stephens Hospital College of Nursing, Delhi., Abraham Ashley ,   Registered Nurse., Jacob Jasmin ,   Registered Nurse., Akansha Singh Angel ,   Registered Nurse, Aakash Healthcare Private Limited, Delhi., Mariyam Philip Kesiya ,   Registered Nurse., Dominic Annie ,   Registered Nurse., Sebastian Sandra ,   Registered Nurse, Venkateshwar Hospital, Delhi.
Published: November 2022

A Descriptive study was conducted to assess the knowledge and practice regarding self-medication among patients visiting outpatient department in a selected hospital of Delhi. A sample of 100 patients was selected using convenient sampling technique. A structured knowledge questionnaire and self-expressed checklist was administered to assess the knowledge and practice regarding self-medication. The data analysis and interpretation were done using descriptive and inferential statistics. Most of the patients visiting outpatient department had average knowledge regarding self-medication and 99% of the patient considered self-medication as an acceptable practice. There was no correlation found between knowledge and practice regarding self-medication.
Facile Methods for the Assembly of Large-Area Perovskite Solar Cells and Mini‑Module: A Step-by-Step Description of Layers Processing
Authors: de Araújo Francineide , Nogueira Ana , de Freitas Jilian
Published: November 2022

Hybrid organic-inorganic perovskites have attracted interest in photovoltaic applications due to their excellent optoelectronic properties and low-temperature processability. From 2009 to 2021, lab-scale perovskite solar cells (PSC) reached a power conversion efficiency (PCE) of 25.7%, and a PCE of 17.9% for perovskite solar modules with an area of 800 cm2. Here, we present an investigation using three deposition techniques, spin-coating, blade-coating, and spraycoating, to process the charge transport layers and the active layer of perovskite solar cells onto 5 cm × 5 cm sized substrates, with device structure glass/fluorine-doped tin oxide (FTO)/c-TiO2/ meso-TiO2+Perovskite/2,2’,7,7’-tetrakis(N,N-di-p-methoxyphenyl-amine)9,9’-spirobifluorene (spiro-OMeTAD) or poly(3-hexylthiophene) (P3HT)/Au. Large-area PSC achieved an opencircuit voltage of around 1.1 V and PCE of 6%. The power generated was sufficient to start a fan. Furthermore, the connection in series of two large-area PSCs generated a voltage of 1.9 V. Then, we developed a simple method for manufacturing a monolithic perovskite mini-module containing two series-connected PSCs without using laser-scribing processes (usually named P1, P2, and P3 processes). This mini-module delivered a voltage of 1.52 V. Both voltages (1.9 and 1.52 V) were enough to turn on a red (or yellow) light-emitting diode (LED). To our knowledge, this is the first scientific report describing the assembly of a large-area n-i-p perovskite single cell and mini-module in Brazil.
Sufistic Approach in Understanding Hadith: Ḥakīm al-Tirmidhī’s Viewpoint
Authors: Arafat Ahmad Tajuddin , Mutma'inah Mutma'inah , Rosyida Hanik
Published: November 2022

This article studies al-Ḥakīm al-Tirmidhī’s viewpoints toward understanding hadith on his work “Nawādir al-Uṣūl fi Ma’rifat Aḥādīth al-Rasūl.” Using the content analysis approach, this study reveals that the primary purpose of transmitting hadith is that the hadith’s message is supposed to be practiced so that happiness in the hereafter can be achieved, not just transmitting hadith from one person to another without any practical implication. So, it not only orients on the chain of transmission but also profoundly understands the matan or its contents. He quotes some hadith in his works to expose the meaning and the essence contained in every hadith and hopes that it can be a guideline of sulūk for those who intend to get closer (taqarrub) to God. Hence, the Sufism viewpoint becomes his basic epistemology in understanding the hadith.Contribution: This article provides a new perspective of the hadith transmitter requirement according to al-Tirmidhī, namely, having a critical view towards everything that is heard and accepted. It also shows that understanding hadith is not just to reveal its meaning but a sulūk for those who want to get closer to Allah.
Adaptive and Compensatory Mechanisms of the Cardiovascular System and
Disease Risk Factors in Young Males and Females
Authors: Abdullah Marzoog Basheer
Published: November 2022

Background:

Cardiovascular disease (CVD) is increasing dramatically in young people and is the leading cause of death worldwide.

Aims:

This study aimed to evaluate differences in the adaptive and compensatory mechanisms of the cardiovascular system (CVS) in young men and women to determine the most significant risk factors and assess the stability of the non-invasive method used in the early detection of CVD risk factors in young people.

Objectives:

Currently, early evaluation of CVD risk factors is possible only through invasive methods, such as the Framingham risk score and the SCORE chart. Therefore, the development of a more flexible and non-invasive method is crucial in large populations.

Methods:

A cohort cross-sectional investigation examined 173 volunteers, divided into two groups according to gender (n1 female=83, n2 male=90), and their heart rate, blood pressure (SBP/DBP), height, weight, and waist and hip circumference were non-invasively measured. Then, the potential adaptation value (R.M. Baevsky et al., 1987), Martinet test (MT), body mass index (BMI), and waist/hip ratio were calculated. Moreover, we collected information on lifestyle risk factors, including tobacco smoking, alcohol consumption, factors related to unhealthy diet, lack of physical activity, sleep deprivation, and anxiety, through special in-person interviews using paper/online questionnaires. The T-test and the x2 tests were applied for statistical analysis.

Results:

Impaired/pathological cardiovascular adaptation was observed in 11.54% of the female group and 46.07% of the male group. In the female group, cardiovascular recovery abnormalities were observed in the SBP, DBP, and HR MT in 20.59%, 16.18%, and 44.12%, respectively, whereas in the male group, 32.50%, 21.25% and 36.25%, respectively. Despite gender, these deviations were accompanied by the prevalence of sympathetic influences in the regulation of CVS functions in 72.73% of the first group and 69.66% of the second group. BMI was violated in 47.19% of males and 29.49% of females. The test results were identical to that in the invasive methods of assessment of CVD risk factors.

Conclusion:

Abnormalities in cardiovascular adaptation mechanisms in young women are less pronounced. Gender-dependent risk factors have high yields, such as obesity, low physical activity, and hypertension, which are more pronounced in men. The usability of the test requires further investigation on a larger sample.
Recent Advances in Biological Active Sulfonamide based Hybrid
Compounds Part C: Multicomponent Sulfonamide Hybrids
Authors: Ghomashi Reihane , Ghomashi Shakila , Aghaei Hamidreza , Massah Samineh , Massah Ahmad Reza
Published: November 2022

Sulfonamides, with the general formula R-SO2NR1R2, have attracted great attention
since the early discovery of sulfonamide-containing antibacterial drugs. The combinations
of certain sulfonamides and other drug molecules to form sulfonamide hybrids
are being used to develop novel formulations with greater effectiveness and in a huge
range of therapeutic applications such as antimicrobial, antifungal, anti-inflammatory, antitubercular,
antiviral, antidiabetic, antiproliferative, carbonic anhydrase inhibitor, antimalarial,
anticancer and other medicinal agents. Part C of this review presents recent advances
in designing and developing multicomponent sulfonamide hybrids containing more
than one biologically active heterocycle, such as coumarin, indole, pyridine, pyrimidine,
pyrazole, triazole, oxazole, oxadiazole, triazine, quinazoline, and thiadiazol. This review
aims to highlight the status of the hybridization technique in synthesizing biological and
computational studies of novel sulfonamide hybrids that were designed and presented between
2016 and 2020.
Reduction of Electron-Rich Nitro Heteroarenes; A Comprehensive Review
Authors: Vengatesh Gopal , Nanjan Pandurangan
Published: November 2022

Amino heterocycles are important in drug design due to their unique intrinsic and
physicochemical properties. Though these molecules look simple, their selective reduction is
challenging because of their rich electron density in the ring. Additionally, reducing nitro
groups in heterocycles is crucial in designing different materials. With this in view, several
reduction methods have been developed and applied to various heterocyclic compounds.
However, there is no dedicated report on these special types of compounds. With careful
analysis, the studies are systematically summarized from conventional methods to advance
materials based on their catalytic activity, durability, recyclability, and stability. Further, detailed
insights are discussed to motivate chemists working in catalysts.
Maternally Expressed Gene 3 Negatively Regulated Decorin to
Supresse Angiogenesis, Proliferation and Migration of Endothelial
Cells
Authors: Dai Dongwei , Zhang Lei , Li Jin , Di Yunhai , Tian Chun‘ou , Liu Jianmin , Hong Bo
Published: November 2022

Background:

Angiogenesis of tumor cells is highly associated with tumor-secreted factors and matrix proteins. However, the underlying mechanism of tumor-secreted factors and matrix proteins during angiogenesis is rarely discussed.

Objectives:

This study investigated the relationship between the maternally expressed gene 3 (MEG3), a tumor-secreted growth factor, and Decorin, a tumor-secreted matrix protein, and evaluated their derivate roles in human endothelial cell development.

Methods:

Human endothelial cells were transiently transfected with a plasmid expressing antisense of Decorin mRNA (shDecorin) and silencing mRNA of MEG3 (siMEG3) or MEG3 over-expressive vectors. A series of qPCR and Western blot analysis was applied to characterize the expressions of MEG3 and Decorin in all transfected cells. Moreover, scratch, Transwell, and Matrigel neovascularization assays were performed to examine three key processes of endothelial cells' angiogenesis, including tubulogenesis, proliferation, and migratory levels. In addition, the cell viability was evaluated at each step via the MTT test.

Results:

The overexpression of MEG3 inhibited angiogenesis and migration of endothelial cells by preventing the expression of Decorin. At the same time, the inhibition of MEG3 via siRNA resulted in an increased expression of Decorin, enhanced tube formation levels, and promoted endothelial cell proliferation and migration. Furthermore, Decorin's knockdown suppressed the angiogenesis and migration of endothelial cells without affecting the expression of MEG3. Importantly, the stimulation of HUVEC cells with exogenous Decorin protein alleviated most phenotypes induced by the upregulation of MEG3.

Conclusion:

Our study demonstrated the anti-growth effects of MEG3 on vasculogenesis and migration of endothelial cells. Thus, by blocking the expression of Decorin in HUVECs, the overexpression of MEG3 repressed their development and might potentially alleviate the ischemic stroke.
Children and Adolescents with Irritable Bowel Syndrome: Treatment and
Management
Authors: Wal Ankita , Wal Pranay , Verma Neha , Pandey Shiv Shanker , Krishnan Karthickeyan , Bhowmick Mithun
Published: November 2022

Background:

Irritable bowel syndrome (IBS) is a disorder that causes stomach pain in children and adolescents. It may also impact one's quality of life. IBS is linked to gastrointestinal issues such as diarrhoea and constipation. Despite the identification of several potential pathophysi-ological pathways, the aetiology of IBS remained unknown

Objective:

The aim of this paper is to discuss the diagnosis, pathogenesis, case studies and treatment of Irritable bowel syndrome in children and adolescents.

Methods:

This systematic review covered relevant papers from the previous ten years that were accessible in Science Direct, Elsevier, NCBI, and Web of Science related to the pathophysiology and function of pharmacological drugs such as antidepressants, antispasmodics, prokinetics, and antibiotics in children with irritable bowel syndrome.

Results:

those have been demonstrated to be effective. This article presents case studies including 50-59 children, which demonstrate a favourable acceptable impact that is more effective than a pla-cebo in terms of reducing symptoms and improving the overall quality of life in children who have irritable bowel syndrome. Furthermore, the majority of the pathophysiological explanations and treatment options discussed are based on adult studies. These major issues arose when treating paediatric IBS, and they must be addressed in order to properly treat children with IBS. Trials that focus on many combinations of pharmacological and non-pharmacological therapies seem to be more helpful.

Discussion:

In recent years, a number of systematic reviews have been conducted to evaluate the efficacy of medication treatments in children for IBS; however, the dependability of these systemat-ic reviews needs to be further investigated owing to the various experimental designs and levels of evidence used. This article highlights paediatric therapy options, including pharmaceutical medica-tions such as antidepressants, antispasmodics, prokinetics, and antibiotics. The goal is to alleviate IBS symptoms while also enhancing the quality of life for children with this illness.
The effects of Tyrosine Kinase Inhibitors (TKIs) in monotherapy and with add-on treatments on Health-related Quality of Life of People with Chronic Myeloid Leukemia: a systematic review of Randomized-Controlled Trials.
Authors: Nardi Antonio E , Sancassiani Federica , Barrui Vanessa , Kalcev Goce , Uras Veronica , Meloni Giulia , Marongiu Luigi , Tamburini Giorgio , Maleci Alberto , Quagliato Laiana A , La Nasa Giorgio , Carta Mauro Giovanni
Published: November 2022

Background:

The era of establishing tyrosine kinase inhibitors (TKIs) in the treatment of chronic myeloid leukemia (CML) changed the outcome and the course of this life-threatening malignancy. People suffering from CML have now a better prognosis and a longer life expectancy by the development of TKIs, even if it requires long term—often lifelong— treatments that are nonetheless associated with improved Health-related Quality of life (HRQoL). However, data on the effects of TKIs on HRQoL are not always systematic: sometimes they were obtained by studies different from RCTs, or without a clear definition of what HRQoL is. The main purpose of this systematic review is to summarize all randomized-controlled trials (RCTs) including HRQoL as main or secondary outcome in patients with CML treated with TKIs or with TKIs plus an add-on treatment.

Methods:

Systematic review by searching for relevant papers in PubMed/Medline and Web of Science with the following keywords: “quality of life” OR “health-related quality of life” OR “QoL” OR “HRQoL” OR “H-QoL” AND “chronic myeloid leukemia”. Interval was set from January 2000 to December 2020.

Results:

40 papers were identified through the search. Out of them, 7 RCTs were included. All the studies used standardized measures to assess HRQoL, even not always specific for CML. 5 RCTs randomized subjects to 2 or 3 arms to evaluate the effects of TKIs of the first, second and third generation in monotherapy. 2 RCTs randomized subjects to TKI therapy plus an add-on treatment versus TKI therapy as usual. The results of all these trials were examined and discussed.

Conclusion:

All the included RCTs pointed out significant findings about the positive effects of TKIs on HRQoL of people with CML, both when they were used in monotherapy or, notably, with an add-on treatment to enhance TKIs effects.
Relationship Between Procrastination and Stress Responses
Authors: Zhang Li Yang , Kato Chieko , Aoki Koichiro , Otsuka Yoshiomi
Published: November 2022

Introduction:

Procrastination is a maladaptive behavior that leads to failure of tasks, and a decrease in self-esteem and negative emotions; this behavior, however, becomes a habit. If procrastination becomes a habit, it will have a negative impact on your body and mind. Previous studies have divided participants by gender, age, etc., and relationships between procrastination and stress have been examined. However, a general relationship between procrastination and stress has not been clarified. This study examined the relationship between procrastination and stress through a questionnaire survey.

Methods:

This study also examined the effects of passive or active procrastination on stress responses through a survey on active procrastination tendency. In addition, surveys were conducted on Japanese and Chinese people, and their answers were analyzed and compared between them. Hypotheses in this study are as follows: there are relationships between the participants’ general procrastination tendency and stress responses (Hypothesis 1); participants with higher general procrastination tendency show higher stress responses than those with higher active procrastination tendency (Hypothesis 2). There are differences in relationships between procrastination tendencies and stress responses between Japanese and Chinese participants (Hypothesis 3). The results of the analysis have been discussed based on differences in cultural and social backgrounds.

Results:

These results showed a positive correlation between general procrastination and stress response in both Japanese and Chinese populations. Active procrastination was found to be positively correlated with stress response in Japanese and negatively correlated in Chinese.

Conclusion:

The results suggest that the relationship between procrastination and stress response is influenced by the subject's cultural background.
Pertumbuhan Dan Hasil Selada (Lactuca sativa L.) Pada Metode Hidroponik Sistem Sumbu Dengan Kerapatan Naungan Dan Konsentrasi Nutrisi Yang Berbeda
Authors: Wijaya Agmey , Fajriani Sisca
Published: November 2022

Selada merupakan sayuran yang dimakan bagian daunnya. Selada memiliki mineral dan vitamin yang baik bagi kesehatan. Selada membutuhkan lingkungan yang sejuk dengan suhu 15-25°C dan cukup air. Cahaya yang terik dapat menurunkan kelembaban dan meningkatkan suhu udara sehingga tanaman selada melakukan transpirasi dengan cepat pada siang hari. Penanaman secara hidroponik tidak membutuhkan tanah dan nutrisi dapat diatur sesuai kebutuhan. Penelitian bertujuan untuk menentukan kerapatan naungan dan konsentrasi nutrisi yang tepat pada pertumbuhan dan hasil tanaman selada metode hidroponik sistem sumbu serta mempelajari lingkungan mikro yang terbentuk dari perlakuan kerapatan naungan yang berbeda. Penelitian dilakukan di Desa Bringin, Kecamatan Badas, Kabupaten Kediri. Penelitian menggunakan Rancangan petak terbagi yang disusun secara faktorial. Petak utama adalah perlakuan kerapatan naungan yang terdiri atas 4 taraf yaitu kerapatan naungan, 0%, 25%, 50% dan 75%. Anak petak adalah perlakuan konsentrasi nutrisi yang terdiri atas 2 taraf yaitu konsentrasi nutrisi 750 ppm dan 1000 ppm. Kombinasi perlakuan menghasilkan 8 kombinasi diulang 3 kali. Perlakuan kerapatan naungan 0% memberikan peningkatan bobot segar pertanaman 9,3%, jumlah daun 9,2% dan panjang akar 3,7% dibandingkan kerapatan naungan 25%. Konsentrasi nutrisi 1000 ppm meningkatkan bobot segar pertanaman 9,1%, jumlah daun 6,3% dan panjang akar 9,6% dibandingkan konsentrasi nutrisi 750 ppm. Perlakuan kerapatan naungan 25% menurunkan intensitas radiasi matahari sebesar 12% dan suhu udara 0,7% sedangkan kelembaban udara meningkat sebesar 1,7% dibandingkan kerapatan naungan 0%.
Respon Pertumbuhan dan Hasil Tanaman Seledri (Apium graveolens L.) pada Pemberian Dosis Nitrogen dan Bahan Organik
Authors: Lesmanasari Maydya , Barunawati Nunun
Published: November 2022

Pemanfaatan seledri selain sebagai sayuranpelengkap atau penyedap rasa juga bermanfaatdi bidang kesehatan. Perbaikan budidaya pada seledri pada lahan dengan kondisi C-organikdan N-tersedia dalam kategori sedang dapatdilakukan dengan pemupukan. Kebutuhanunsur nitrogen pada seledri dapat dipenuhidengan pupuk nitrogen. Pengoptimalanserapan hara pada tanaman dilakukan denganpenambahan bahan organik. Selainmeningkatkan ketersediaan unsur hara, bahanorganik dapat memperbaiki kualitas tanahsehingga penyerapan unsur hara optimal.Penelitian dilakukan untuk mempelajariinteraksi dosis nitrogen dan bahan organikserta mendapatkan dosis nitrogen dan bahanorganik yang tepat terhadap pertumbuhan dan hasil tanaman seledri. Penelitian dilaksanakandi Desa Sumberejo, Kota Batu pada bulan Mei hingga Juli 2022. Penelitian merupakanpercobaan faktorial yang di rancangmenggunakan Rancangan Acak Kelompok(RAK) dengan 3 ulangan terdiri 2 faktor. Faktorpertama, dosis nitrogen terdiri dari 4 taraf yakni25 kg ha-1, 75 kg ha-1, 125 kg ha-1 dan 175 kg ha-1. Faktor kedua, dosis bahan organik berupakotoran kambing terdiri dari 3 taraf meliputi 0 ton ha-1, 15 ton ha-1, dan 30 ton ha-1. Variabelpengamatan meliputi panjang tanaman, jumlahdaun, jumlah anakan, bobot segar, dan shoot:root rasio. Analisa data menggunakan uji F pada taraf 5%. Hasil yang berbeda nyatadilanjutkan dengan uji BNJ 5%. Hasil penelitiantidak menunjukkan interaksi antara pemberiandosis nitrogen dan bahan organik terhadappertumbuhan dan hasil pada tanaman seledri. Pemberian dosis nitrogen 125 kg ha-1 dan 175 kg ha-1 meningkatkan pertumbuhan panjangtanaman, jumlah anakan, dan jumlah daunmasing-masing sebesar 18,5%; 40,3%; dan 16,57%. Pada komponen hasil, pemberiandosis nitrogen 125 kg ha-1 dan 175 kg ha-1meningkatkan bobot segar konsumsi sertashoot:root rasio masing-masing sebesar82,44%; dan 118%. Sedangkan pemberianbahan organik tidak berpengaruh nyataterhadap pertumbuhan dan komponen hasiltanaman seledri.
Pengaruh Jenis dan Konsentrasi Pupuk Organik Cair (POC) terhadap Pertumbuhan dan Hasil Tanaman Bunga Kol (Brassica oleracea var. botrytis L.)
Authors: Anastasya Allisa , Sudiarso Sudiarso
Published: November 2022

Tanaman bunga kol banyak digemari oleh masyarakat Indonesia. Penggunaan pupuk kimia dapat mengancam keseimbangan ekosistem dan menurunkan kesuburan tanah. Upaya dalam mengurangi penggunaan pupuk kimia yaitu dengan menggunakan pupuk organik cair. Penelitian ini untuk mengetahui, mengukur dan menganalisis pemberian jenis dan konsentrasi pupuk organik cair yang berbeda untuk meningkatkan pertumbuhan dan hasil bunga kol. Bahan yang digunakan yaitu pupuk ZA, pupuk SP-36, pupuk KCl, air, benih bunga kol varietas PM 126 F1, pupuk kandang kambing, POC Nasa, POC Green Tonik dan POC Bio Sugih. Penelitian ini menggunakan rancangan acak kelompok (RAK) dengan kombinasi perlakuan P1: POC Nasa 1 ml/l Air, P2: POC Nasa 2 ml/l Air, P3: POC Nasa 3 ml/l Air, P4: POC Green Tonik 1 ml/l Air, P5: POC Green Tonik 2 ml/l Air, P6: POC Green Tonik 3 ml/l Air, P7: POC Bio Sugih 1 ml/l Air, P8: POC Bio Sugih 2 ml/l Air, P9: POC Bio Sugih 3 ml/l Air. Penelitian dilaksanakan pada bulan Februari hingga April 2022 di Lahan Percobaan Fakultas Pertanian Universitas Brawijaya, Kelurahan Jatimulyo, Jawa Timur. Hasil penelitian menunjukkan bahwa Jenis dan konsentrasi POC Green Tonik 3 ml/l memberikan hasil terbaik terhadap pertumbuhan dan hasil tanaman bunga kol. Pemberian POC Green Tonik 3 ml/l menghasilkan panen bunga kol per hektar sebesar 15,67 t ha-1 atau lebih tinggi 56,7% dibandingkan POC Green Tonik 1 ml/l.
Pengaruh Pengendalian Gulma Terhadap Pertumbuhan dan Hasil Tanaman Bawang Putih (Allium sativum L.)
Authors: Rozaqi Ahmad , Sebayang Husni Thamrin
Published: November 2022

Bawang putih (Allium sativum L.) merupakan jenis tumbuhan umbi-umbian yang dapat hidup di daerah dataran tinggi dan dataran rendah. Penelitian yang telah dilakukan bertujuan untuk mendapatkan cara pengendalian gulma yang tepat pada pertumbuhan dan hasil tanaman bawang putih. Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) dengan 9 perlakuan dan 3 ulangan. Perlakuan yang digunakan yaitu tanpa pengendalian gulma (P0), penyiangan setiap 7 hari (P1), penyiangan 20, 30, dan 45 hst (P2), herbisida oksifluorfen 240 EC (P3), herbisida oksifluorfen 240EC + penyiangan 30 hst (P4), mulsa jerami (P5), mulsa jerami + penyiangan 30 hst (P6), mulsa plastik hitam perak (P7), mulsa plastik hitam perak + penyiangan 30 hst (P8). Alat yang digunakan dalam penelitian ini antara lain cangkul, meteran, alat tugal, pipa air, ember, penggaris, timbangan analitik, alat tulis, papan penanda, sprayer dan kamera. Bahan yang digunakan dalam penelitian ini adalah benih bawang putih varietas lumbu hijau, pupuk kandang, pupuk urea, SP-36 dan KCl, mulsa jerami, mulsa plastik hitam perak, herbisida oksifluorfen 240 EC. Penelitian ini dilaksanakan mulai 18 Januari 2021 sampai dengan 3 Mei 2021, yang bertempat di Desa Tawangsari, Kecamatan Pujon, Kabupaten Malang, Provinsi Jawa Timur. Pengamatan meliputi pengamatan pertumbuhan, hasil, dan pengamatan gulma. Hasil penelitian menunjukkan terdapat pengaruh nyata antara perlakuan berbagai macam pengendalian gulma terhadap jumlah daun, panjang tanaman, bobot segar, bobot kering umbi, diameter umbi, dan hasil panen tanaman bawang putih (ton ha-1). Penyiangan setiap 7 hari dan aplikasi mulsa plastik hitam perak + penyiangan 30 hst efektif mengendalikan gulma tanaman bawang putih.
The Use and Structure of Emergency Nurses’ Triage Narrative Data: Scoping Review
Authors: Picard Christopher , Kleib Manal , Norris Colleen , O'Rourke Hannah M , Montgomery Carmel , Douma Matthew
Published: November 2022

Background

Emergency departments use triage to ensure that patients with the highest level of acuity receive care quickly and safely. Triage is typically a nursing process that is documented as structured and unstructured (free text) data. Free-text triage narratives have been studied for specific conditions but never reviewed in a comprehensive manner.

Objective

The objective of this paper was to identify and map the academic literature that examines triage narratives. The paper described the types of research conducted, identified gaps in the research, and determined where additional review may be warranted.

Methods

We conducted a scoping review of unstructured triage narratives. We mapped the literature, described the use of triage narrative data, examined the information available on the form and structure of narratives, highlighted similarities among publications, and identified opportunities for future research.

Results

We screened 18,074 studies published between 1990 and 2022 in CINAHL, MEDLINE, Embase, Cochrane, and ProQuest Central. We identified 0.53% (96/18,074) of studies that directly examined the use of triage nurses’ narratives. More than 12 million visits were made to 2438 emergency departments included in the review. In total, 82% (79/96) of these studies were conducted in the United States (43/96, 45%), Australia (31/96, 32%), or Canada (5/96, 5%). Triage narratives were used for research and case identification, as input variables for predictive modeling, and for quality improvement. Overall, 31% (30/96) of the studies offered a description of the triage narrative, including a list of the keywords used (27/96, 28%) or more fulsome descriptions (such as word counts, character counts, abbreviation, etc; 7/96, 7%). We found limited use of reporting guidelines (8/96, 8%).

Conclusions

The breadth of the identified studies suggests that there is widespread routine collection and research use of triage narrative data. Despite the use of triage narratives as a source of data in studies, the narratives and nurses who generate them are poorly described in the literature, and data reporting is inconsistent. Additional research is needed to describe the structure of triage narratives, determine the best use of triage narratives, and improve the consistent use of triage-specific data reporting guidelines.

International Registered Report Identifier (IRRID)

RR2-10.1136/bmjopen-2021-055132
Pengaruh Jenis Bubur Buah dan Pemanis terhadap Karakteristik Fisik, Kandungan Gizi, dan Aktivitas Antioksidan Selai Kersen (Muntingia calabura L.) Lembaran
Authors: Pratiwi Tiara Firstianty , Setiawan Budi , Marliyati Sri Anna
Published: November 2022

Kersen (Muntingia calabura L.) merupakan buah yang mengandung antioksidan dan serat yang bermanfaat bagi kesehatan. Buah kersen masih belum banyak dimanfaatkan menjadi suatu produk makanan olahan. Oleh karena itu, dikembangkan produk makanan berbahan dasar kersen seperti selai kersen lembaran. Penelitian ini bertujuan untuk mengetahui pengaruh bubur buah yang disaring/tidak disaring serta menggunakan fruktosa cair/fruktosa cair+stevia pada selai lembaran, menganalisis karakteristik fisik, kandungan gizi, aktivitas antioksidan, dan kontribusi energi dan zat gizi per takaran saji selai kersen lembaran. Penelitian ini didesain secara eksperimental dengan menggunakan Rancangan Acak Lengkap (RAL) Faktorial. Faktor pertama yaitu penyaringan bubur buah meliputi A1 (disaring) dan A2 (tidak disaring), sedangkan faktor kedua yaitu jenis gula meliputi B1 (fruktosa cair) dan B2 (fruktosa cair + stevia). Keempat formula selai lembaran dilakukan analisis karakteristik fisik (total padatan terlarut, warna L, a+, b+, hue, dan chroma), kandungan gizi (kadar proksimat, serat pangan, dan total gula), aktivitas antioksidan, serta kontribusi energi dan zat gizi per takaran saji. Data dianalisis menggunakan uji Two-way Anova dan uji lanjut Duncan pada taraf 5%. Hasil penelitian menunjukkan tidak ada perbedaan yang signifikan pada hasil analisis total padatan terlarut, warna L, b+, chroma, hue, kadar proksimat, serat pangan, dan aktivitas antioksidan pada formula selai kersen lembaran, tetapi terdapat perbedaan yang signifikan untuk hasil warna a+ dan total gula. Formula selai kersen lembaran dengan penyaringan dan penggunaan fruktosa cair + stevia memiliki kandungan energi lebih rendah 30,15-37,9% dan kandungan gula lebih rendah 41,25-47,78% dibandingkan dengan selai buah komersil, sehingga dapat dijadikan sebagai alternatif selingan bagi seseorang yang mengurangi kalori dan asupan gula. Formula ini juga memiliki kandungan serat yang tinggi yaitu sebesar 7,77% atau 2,72 g/35 g.
Preparation of Material for Adsorption Ag(I) in the Solution
Authors: Gao Liwei , Luo Wenxiang , Zhang Yikun , Shen Hanfang , Lang Chunyan
Published: November 2022

The application of silver in electronics, jewelry, catalytic and other industries often produces a large amount of silver-containing wastewater, which causes serious impact to the surrounding environment and human health, while silver has a certain economic value attached to it. Therefore, how to effectively treat and recover Ag(?) from the silver-containing wastewater is a hot topic of concern at present. In order to seek an efficient and environmentally friendly adsorbent, this paper compared the adsorption efficiency of purified, thermally modified, acid modified and thermally-acid modified Bentonite on silver, selected an economical and reasonable purified clay as a carrier, and then completed the preparation of modified Bentonite as well as the optimization of conditions with sodium silicate as a surfactant and 3-mercaptopropyltrimethoxysilane as a modifier. The experiments showed that under the conditions of sodium silicate dosage of 15% of Bentonite, Bentonite and modifier dosage of 1:1, solution pH of 9, temperature of 45 °C and modification time of 5 h, the synthesized sulfhydryl modified Bentonite has good adsorption performance on Ag(?), and its adsorption capacity can reach 293.7 mg·g-1.