bluuebunny/crossref_metadata_2025 huggingface dataset:
Visual management system in organization: principles of construction and practical instruments of implementation
Authors: Semibratsky Maksim
Published: September 2020

The paper presents the results of the study of the visual control system in organizations. The enterprises of various sectors of the economy are selected as an object of the research. In modern economic realities, the efficiency of the organization's activities largely depends not only on the introduction of innovations in production, but also on the structural reform of the management model. Today the issues of growth of labor productivity are actively discussed at all levels of government. These issues are a priority task for the management of various companies, regardless of area of activity. It has been proved that the application of the principles and tools of lean manufacturing, many of which do not require high implementation costs, can be used for increasing the efficiency of the organization. The importance of study of visual management tools has been emphasized; the advantages of visual management tools (reduction of losses, reduction of the production cycle, ensuring the timely delivery of stocks to warehouses, etc.) have been listed. The rules for implementation of the visual management tools in the activities of any enterprise are discussed in detail. The visual management tools should reflect the requirements for safety, production or performance any standard operation; they should be simple and unambiguous in understanding and sufficiently illustrative and noticeable from afar. There has been taken an attempt to highlight a number of universal visual management tools using the scientific principles of building the system that can be applied in the work of many organizations, regardless of type of activity and form of ownership
Concepts, types and features of forming flow processes of sea port
Authors: Volynskiy Ilya Aleksandrovich
Published: September 2020

The article outlines the specific features of intensive development of the theory of logistics and supply chain management in modern Russia contributing to the widespread introduction of logistics management in enterprises and organizations in various sectors of the economy, which determines the need to clarify the conceptual framework, taking into account the industry characteristics of market entities. The study of the modern conceptual and terminological apparatus of logistics made it possible to clarify the concepts of cargo flow, ship flow, flow of logistics services, logistics flow of the seaport in relation to the seaport. The classification of these flows by a number of features is presented and their parameters are refined. Freight flows in the seaport are classified according to the following criteria: attitude to the port's logistics system, type of cargo, cargo compatibility, transshipment options. The parameters of the seaport's cargo traffic are considered: volume of cargo transshipment by type for a certain period of time, area of warehouses, capacity of tanks for storing cargo, overall, weight and physicochemical characteristics of the cargo. The traffic flows are characterized by such parameters as a number of calls, time horizons of loading or unloading, vessel idle time, laydays, average gross tonnage per call, gross tonnage of vessels, etc. Information and financial flows in relation to the seaport have been systematized. There are listed the functions of the seaport as a transport and logistics complex in accordance with the Merchant Shipping Code and the Statute of FSUE Rosmorport: production, organizing, innovation, environmental, planning and servicing. A business model of the cargo flow of a seaport is proposed, which details its structure and allows to regulate the interaction of subjects of the micrologistic system of the port. Logistics services provided by logistics intermediaries in the seaport are systematized, their content characteristics are specified; the place and role of logistics services in the management system of the seaport are determined.
Analysis, prospects and problems of autdoor advertising market development
Authors: Vinnik Alina Evgenievna , Tkhorikov Boris Aleksandrovich
Published: September 2020

The article focuses on the problems of the rapidly developing segment of the advertising line - outdoor advertising. The results of studying the dynamics and structure of the outdoor advertising market allowed to consider this segment promising, since outdoor advertising is the only media channel, in which sales have steadily increased over the past ten years. It has been stated that outdoor advertising irritates a relatively small number of respondents (14%); for comparison: TV advertising - 56%, Internet advertising - 67% of respondents. The structure of the advertising market of the Russian Federation from 2008 to 2019 has been analyzed. The analysis has illustrated that the most significant segment of the global outdoor advertising market is roadside billboards; second and third places are occupied by street furniture and transit advertising. Roadside billboards are being phased out in many markets due to tightening legislation; according to the experts, by 2021 the share of this segment will decrease by 4%. The research was carried out taking into account the data of such businesses as MAGNA and the Association of Communication Agencies of Russia. The US has the world's largest outdoor advertising market; Japan has the highest outdoor advertising spending. The key factors that ensure the priority of outdoor advertising in comparison with other advertising media are highlighted: wide audience coverage, largest advertising space, relatively low cost of advertising contact, variety of types and formats of advertising structures, etc. Topical problems are formulated that hinder the further growth of the studied segment: low level performance and quality of visual content, difficulties in assessing the effectiveness of outdoor advertising.
Estrutura financeira empresas ramo de calçados
Authors: Francisco Jose Roberto de Souza , Rocha Amauri Santos , Amaral Hudson Fernandes
Published: September 2020

A indústria de calçados no mercado brasileiro é composta por 7,7 mil empresas, ocupa o terceiro lugar mundial em produção e o quarto lugar mundial como mercado consumidor. Neste contexto, esta pesquisa tem por objetivo analisar e avaliar os resultados financeiros de quatro organizações de capital aberto do ramo de calçados por meio dos balanços patrimoniais do período de 2012 a 2016 publicados no site da Comissão de Valores Mobiliários. O trabalho foi desenvolvido com base nos cálculos e análise de índices de liquidez do modelo tradicional e do modelo dinâmico. O modelo dinâmico exigiu primeiramente a reclassificação das contas do balanço patrimonial para que fossem calculados os índices base do modelo com os quais foi identificada a estrutura que representa o nível de risco financeiro de cada organização. Esta pesquisa buscou apresentar uma análise conjunta entre o modelo tradicional de liquidez e o modelo dinâmico para que sejam tomadas ações que busquem o equilíbrio financeiro das organizações tanto no curto como no longo prazo. A metodologia aplicada na pesquisa realizada foi caracterizada como do tipo descritiva, pois buscou descobrir a existência de associações e comportamentos dos índices financeiros calculados no período analisado, sendo análise de liquidez no método tradicional e no método dinâmico. De acordo com o resultado da pesquisa foram identificadas três estruturas e situações financeiras segundo a classificação proposta no modelo dinâmico, sendo elas: situação sólida, para a empresa Grendene, insatisfatória, para a empresa Alpargatas e péssima para as empresas Cambuci e Vulcabrás. Foi apresentado um quadro resumo para comparação da estrutura e situação financeira bem como o ranking considerando o índice que cada empresa utilizou de seus recursos de curto prazo para financiar seus investimentos de longo prazo.
Palavras-chaves: Estrutura Financeira. Ramo Calçados. Modelo Tradicional. Modelo Dinâmico.
Can oocytes repair fragmented DNA of spermatozoa?
Authors: Ješeta Michal , Myšková Markéta , Žáková Jana , Crha Igor , Crha Karel , Chmelikova Eva , Kistanova Elena , Ventruba Pavel
Published: September 2020

Approximately half of the cases of infertility are due to male factor. In many cases the underlying cause of male infertility is not discovered and, therefore, the condition is considered idiopathic. Examination of morphology, motility, concentration and total sperm count is very important but not sufficient for complex men fertility evaluation. Sperm DNA integrity is a very important one. Sperm DNA can be fragmented by several internal or external factors. In immature sperm cells, the DNA can be repaired by reparatory mechanisms of spermatogonia or spermatocytes. However, in a haploid mature sperm cell, these fragments can not be repaired by male and the fragmented DNA is transferred to oocyte. Oocytes are able to repair male fragmented DNA after their fertilization. A quality embryo can repair damaged sperm DNA and the repair system depends on cytoplasmic and genomic quality of the oocyte. The ability of oocyte to repair sperm DNA strong depend on quality of fertilized oocytes.

Running title: Oocyte and DNA repair
Cryptocurrencies as an asset class in portfolio optimisation
Authors: Holovatiuk Olha
Published: September 2020

In this paper, cryptocurrencies are analysed as investment instruments. The study aims to verify whether they can be classified as an asset class and what kind of benefits they may bring to the investor's portfolio. We used 6 indices as proxies for the major asset classes, including the cryptocurrency index CRIX, for all cryptographic assets.

Cryptocurrencies relatively fully satisfied 7 asset class requirements, namely stable aggregation, investability, internal homogeneity, external heterogeneity, expected utility, selection skill and cost-effective access. It was found that crypto assets have diversification properties. Portfolio optimisation with the Modern Portfolio Theory showed an increase in the Sharpe ratio of tangency portfolios with the inclusion of CRIX. However, the Post-Modern Portfolio Theory identified significant deterioration of the downside risk and the Sortino ratio.
Radar reflectivity signatures and possible lead times of warnings for very large hail in Poland based on data from 2007-2015
Authors: Pilorz Wojciech , Łupikasza Ewa
Published: September 2020

Hail involving very large hailstones (maximum diameter ≥ 5 cm), is a rare but very hazardous phenomenon in Poland, and can be forecast using reflectivity signatures. Every year, Poland experiences from one to over a dozen storms with such large hailstones. Despite the current recommendations regarding polarimetric techniques used in hail risk monitoring, Poland does not have a fully polarimetric radar network. Therefore it is essential to check hail detection capabilities using only reflectivity techniques based on individual radar systems involving hail detection algorithms such as Waldvogel et al. (1979) or Vertically Integrated Liquid thresholds connected with manual signature analysis to get better warning decisions. This study is aimed to determine the reflectivity features, thresholds and lead times for nowcasting of severe storms with very large hailstones in Poland, using data from the Polish radar system and from the European Severe Weather Database for the period 2007–2015. Most incidents involving very large hailstones were linked to supercell storms with distinctive reflectivity signatures, however, some storms with extremely large hailstones presented very poorly developed signatures. These signatures enabled the prediction of hail involving very large hailstones approximately 29 minutes before it fell. The Lemon (1980) criterion and WER were found to be the best hail predictors for Polish radar system conditions.
Functional traits of okra cultivars (Chinese green and Chinese red) under salt stress
Authors: Azeem Ahmad , Javed Qaiser , Sun Jianfan , Nawaz Muhammad I. , Ullah Ikram , Kama Rakhwe , Du Daolin
Published: September 2020

Two okra cultivars (Chinese green and Chinese red) were subjected to salt stress for 12 weeks. Salt stress treatments T1 (20.8 mM), T2 (103.3 mM), T3 (180.0 mM) and T4 (257.0 mM) were applied with equal proportions of NaCl and CaCl2 in Hoagland nutrient solution. Salt stress significantly affects photosynthesis, transpiration, stomatal conductance, water use efficiency, water potential, plant height, root length, fresh weight and dry weight of both okra cultivars in every salt stress treatment. At T2, T3 and T4, Chinese red plants maintained their physiological and growth traits up to Weeks 9, 6 and 3, respectively; beyond these salt-stress durations, growth reductions were found. Similarly, Chinese green plants maintained their growth up to Weeks 9, 5 and 3, respectively, at T2, T3 and T4 treatments. In comparison, Chinese red showed more tolerance than Chinese green. According to the results, the third and ninth weeks are the tolerance threshold limits for both cultivars to sustain their physiological traits and growth under T4 and T2 salinity treatments. Similarly, Chinese red has the threshold limit to bear T3 treatment up to the eighth week and Chinese green, up to the fifth week. Thus, this study provides a new method to determine the threshold value of crops with respect to duration under salt stress. This finding would be useful in the field of water saving and utilisation of saline water resources.
Intensity of heat stress in 2015 and 2018 summer seasons in the region of the Lower Silesia (Poland)
Authors: Miszuk Bartłomiej
Published: September 2020

The main goal of this paper was to assess the intensity of heat stress in Lower Silesia, Poland, during selected weather events characterized by high air temperatures. The complex impact of weather on the thermal load of the human organism is presented using the Universal Thermal Climate Index (UTCI). The analysis was carried out for the 2015 and 2018 summer seasons and compared with the multiannual period of 1971–2018. It was based on meteorological data from the IMGW-PIB stations of Wrocław, Jelenia Góra and Śnieżka. In order to examine how heat conditions affect UTCI in different geographical regions, stations located at different altitudes and representing the lowlands, the lower mountain zone and the summit zone of the Sudetes Mountains were considered. The research showed that during the most extreme thermal events, UTCI values in the lowlands and the lower mountain zones can be among the highest heat stress classes. In the summit zone, the maximum UTCI values are usually classed as ‘no thermal stress’.
Effects of abiotic factors on co-occurring Carabus (Coleoptera: Carabidae) species
Authors: Fülöp Dávid , Bérces Sándor , Szabó Péter , Samu Ferenc
Published: September 2020

The members of the genus Carabus are among the most intensively studied beetle taxa, but many aspects of their autecology are still unexplored. We aimed to study the relationship between measured abiotic parameters and the spatial and temporal distribution of signature carabid species. Carabus assemblages were sampled by pitfalls at six sites belonging to two nearby locations, both forest habitats: in valley and in hill-top position. The sites showed variation in microclimatic and soil characteristics, to which the seven species caught showed specific spatial associations. Carabus scheidleri and C. coriaceus were ubiquitists, occurring at all sites. The habitat specialist C. violaceus germari indicated valley sites with high humidity, lower temperature, limy soil and higher pH, whereas the other specialists, C. nemoralis and C. convexus were strongly associated with the dry, warm, more acidic hill habitat. Remaining species were associated with specific sites and environmental features. The species also exhibited specific phenological patterns corresponding with their habitat preference. Hill habitat species exhibited peak activity density during the hottest summer period, whereas most other species had an activity depression during that period. The results suggest that although Carabus activity density patterns are species specific, they are largely affected by temperature both spatially and temporally.
PSICOLOGIA ORGANIZACIONAL: ANÁLISE DOS VALORES ORGANIZACIONAIS DE UMA ACADEMIA
Authors: BARBOSA Jordâna Parreira , OLIVEIRA Karem Sabrina da Cruz , FORESTO-DEL COL Denise Rossi
Published: September 2020

A identidade organizacional de uma empresa é composta de visão, missão e valores e é por meio deste conjunto que a organização apresenta para seus colaboradores o motivo de existir e onde pretende chegar. Os valores organizacionais são formas de conhecer a realidade organizacional e podem ser escolhidos na formação da empresa ou ao longo de sua história, recebendo influência dos fundadores e colaboradores. A partir do exposto, o objetivo deste trabalho foi identificar os valores organizacionais na concepção dos colaboradores e dos gestores dentro de uma academia. Este trabalho caracterizou-se por uma pesquisa quantitativa exploratória e os instrumentos utilizados foram: o Questionário Sociodemográfico, o Inventário de Perfil de Valores Organizacionais (IPVO) e a Escala de Clima Organizacional (ECO). Após análise de dados, foram identificados os valores organizacionais de colaboradores e gestores em duas percepções distintas, o que sugere que há fatores divergentes na concepção desses valores. Com efeito, é relevante ressaltar a necessidade de alinhar tais concepções para fortalecimento da cultura organizacional.

 

ORGANIZATIONAL PSYCHOLOGY: ORGANIZATIONAL CULTURE REVIEW AT A GYM

 

ABSTRACT

The organizational identity of a company comprises vision, mission, and values, through that set of principles the company provides its employees the reason to exist and where they aim to go. Organizational values are approaches the organizational reality and may be chosen during the creation of the company or even along its trajectory, being influenced either by founders and employees. Hence we see, this paper aims to identify organizational values from the administrators and employees’ views at a gym. This paper describes exploratory quantitative research using a Sociodemographic Questionnaire, Organizational Culture Profile Inventory (OCPI), and Organizational Climate Scale (OCS) as tools. After data analysis, administrators and employees’ values were identified in two different views, which suggest divergent factors in the conceptions of those values. Consequently, it is important to note the necessity to align such conceptions in order to strengthen the organizational culture. 

 

Keywords: Organizational Culture. Organizational Psychology. Organizational Values.
Factors of development and introduction of clean coal-mining technologies in the world economy
Authors: Zhiznin S. Z. , Cherechukin A. V.
Published: September 2020

Despite the route lined out since the turn of the 21st century toward the use of renewable energy sources, as of today and for the nearest decades, the fossil energy resources represent the critical part in the world economy. Fossil fuels will keep prevailing in the energy budget of the most countries in 2020 according to the long-term forecasts of the International Energy Agency and by estimates of the other authoritative sources. In the electric energy production, the contribution of coal in 2020 is the largest worldwide and continues growing owing to high-level consumptions in China, India, developing countries in Southeastern Asia, as well as in the mature economies of Japan and Australia. The huge own reserves of coal provide the developing economies with relatively cheap and reliable source of energy, the underside of which is the increased environmental damage. It is critical to develop and investigate approaches to minimization of technological environmental impact at the preserved balance between the economic advance, social welfare and environmental conservation. In the coal-powered energy generation, such approach is application of clean mining technologies. In order to identify application features of such technologies in modern conditions and in the future, it is necessary to review the historical background of economically efficient solutions, the engineering capabilities and the global market conditions in terms of the United States of America as the top coal producer and consumer among the mature economies possessing the advanced coal mining technologies. The outcome of the review is also helpful in the analysis of economic efficiency of clean technologies to be introduced in the coal industry in Russia. Thus, the aim of this article is to examine development and introduction of clean coal technologies in terms of the U.S.A. for tracing promising trends in the conditions of a global economic system.
Factors Affecting Science Research Motivation of Lecturers of Hanoi University
Authors: Thuong Le Thi
Published: September 2020

By synthesizing domestic and foreign studies related to the scientific research motivation of lecturers, considering the factors of studies models, inheriting suitable research results to build model of factors influencing to the scientific research motivation of lecturers of Hanoi University. This study applied factor analysis (EFA) to explore the factors affecting the motivation of scientific research based on a dataset of 218 teacher responses. At the same time, the research conducted in-depth interviews with 09 lecturers at Hanoi University. The analysis results show that the proposed factors in the model have different influence on the scientific research motivation of Hanoi University lecturers including: Professional competence of lecturers, Lecturer's social issues, Research environment, School’s support for scientific research activities and Lecturers' awareness of scientific research. These factors explained 61.81% of the influence on the scientific research motivation of lecturers.
MODIFICACIÓN DE LA RIGIDEZ MENTAL Y DE CONDUCTAS DISRUPTIVAS ASOCIADAS EN UN NIÑO DIAGNOSTICADO CON TRASTORNO DEL ESPECTRO AUTISTA (TEA)
Authors: León Cruz Inmaculada
Published: September 2020

El Trastorno del Espectro Autista (TEA) es un trastorno del neurodesarrollo caracterizado por déficits en la comunicación e interacción social en diversos contextos, así como por patrones restrictivos y repetitivos de conducta, actividades e intereses. Los niños diagnosticados con TEA muestran una gran rigidez mental frente a los cambios, por lo que resulta necesaria la anticipación de las actividades que se van a llevar a cabo, así como la anticipación de los cambios que se van a realizar en su rutina. En el presente trabajo de fin de grado se desarrolla una propuesta de intervención para un alumno diagnosticado con TEA matriculado en el aula específica de autismo del colegio Lope de Vega (Almería), en concreto, se trabajará la modificación de la rigidez y de las conductas disruptivas asociadas que presenta el niño (pegar, pellizcar y decir “trompeta” y “coche”). Para ello, se utilizarán las técnicas de modificación de conducta conocidas como reforzamiento positivo y omisión, la economía de fichas y las historias sociales, todo ello a través de dibujos y pictogramas. Respecto a los resultados esperados, se prevé que la consecución de los objetivos propuestos se dé a lo largo de un trimestre escolar (70 días).
PROGRAMA DE INTERVENCIÓN DE LA FIGURA MATERNA PARA EL CUIDADO Y PREVENCIÓN DE LA OBESIDAD INFANTIL
Authors: Rojas-Ramirez Ana Teresa , Reséndiz-Gómez Erik Isai , García-Cortés José Manuel
Published: September 2020

De manera cultural la mujer ha tenido que desempeñarse en el hogar atribuyéndosele el rol de cuidadora de los hijos, siendo la encargada en gran medida de la alimentación de los niños. La presente investigación se interesó por el estudio de la obesidad infantil, considerando el papel que posee la figura materna y sus estereotipos sobre esta problemática. El alcance de la investigación fue de tipo correlacional, con un diseño no experimental-transversal y un enfoque cuantitativo. Se aplicó una batería de instrumentos que abarca las variables: depresión, alimentación emocional, creencias irracionales, figura materna, obesidad infantil y familia. Se aplicó a madres con un rango de edad de entre 25 y 49 años, con al menos un hijo estudiando los primeros años de educación básica de la región de Nezahualcóyotl y Otumba.Los resultados muestran correlaciones significativas entre las variables de saciedad, indiferencia creencias irracionales, alimentación como base del bienestar y emociones. Con estos resultados, se diseñó un programa de intervención, el cual fue aplicado a través de la página “Llenos de amor” en Facebook.
SOFIA BISI ALBINI, LUCHADORA ACTIVA Y SOLIDARIA DESDE UNA PERSPECTIVA FEMINISTA
Authors: Bartolotta Salvatore , Moreno Celeghin María Gracia
Published: September 2020

Sofia Bisi Albini fue una de las protagonistas más destacadas de la lucha por los derechos de las mujeres en el último cuarto del siglo XIX y en los primeros años del siglo XX. Su labor como escritora, colaboradora en revistas y fundadora de varias de las más importantes publicaciones de su época, contribuyó a asentar el nuevo papel que la mujer debía asumir en la sociedad: un rol participativo y solidario que se traduciría en una aportación práctica a la resolución de los problemas de la sociedad, en especial los relacionados con la educación femenina.
LAS BUENAS MUJERES DE FINALES DE LA EDAD MEDIA. RECONSTRUCCIÓN DE UN MODELO A PARTIR DE LAS FUENTES VASCAS
Authors: Castrillo Casado Janire
Published: September 2020

Este trabajo analiza las características que conformaban el arquetipo de buenas mujeres en las postrimerías de la Edad Media. Su reconstrucción se realiza a través de datos extraídos de fuentes vascas de diversa tipología, que van desde fueros territoriales y ordenanzas municipales de varias villas, hasta documentos notariales custodiados en archivos municipales, principalmente testamentos, y juicios librados en la Chancillería, junto a citas extraídas de algunas crónicas. A partir del estudio de dicho conjunto documental, se esboza una imagen de las principales cualidades que se atribuían a las mujeres virtuosas: la castidad, la asistencia parental y vecinal, la devoción y la caridad, el recato y el comedimiento.
RESEÑA: BUIO. DACIA MARAINI
Authors: González Rodríguez Begoña
Published: September 2020

Los doce relatos que Dacia Maraini expone en Buio muestran a través de sus protagonistas crudas realidades a las que mujeres o niños se exponen. La escritora busca denunciar una serie de violencias que, como es habitual afectan a los más desamparados.
WHITE WHALE
Authors: Kell Katrina
Published: September 2020

White Whale. A short Story by Katrina Kell.
LITERASI VISUAL DALAM PROSES BERKARYA MAHASISWA DESAIN
Authors: Khamadi Khamadi , Setiawan Agus
Published: September 2020

Abstrak: Kemampuan literasi visual mahasiswa desain yang kurang menjadikan karya yang dihasilkan kurang komunikatif. Mahasiswa cenderung mengejar sisi teknis dan estetis dalam proses kreasi visualnya dan cenderung kurang menguasai konsep komunikasi pesan yang ingin disampaikan. Hal ini terjadi akibat karena kurangnya pemahaman terhadap proses literasi visual. Melalui model literasi visual oleh Hattwigg, dkk yang membagi literasi visual dalam tujuh komponen kemampuan literasi, fenomena literasi visual mahasiswa desain saat ini akan dianalisis untuk mendapatkan gambaran dan strategi penguatan kemampuan literasi visual selanjutnya. Sebagai hasilnya, mahasiswa desain masih kesulitan dalam menelusuri informasi visual dan menggunakan image visual yang ada dalam menghasilkan karya visual yang bermakna.

Kata Kunci: Desain, Kreasi Visual, Literasi Visual

Abstract: The lack of visual literacy skills of design students makes the resulting work less communicative. Students tend to pursue the technical and aesthetic side in the process of visual creation and tend to lack the mastery of the concept of communication of the message to be conveyed. This happens due to a lack of understanding of the visual literacy process. Through the visual literacy model by Hattwigg, et al., Who shares visual literacy in seven components of literacy ability, the phenomenon of visual literacy of current design students will be analyzed to obtain an overview and strategy for strengthening visual literacy skills further. As a result, design students still have difficulties in tracing visual information and using existing visual images in producing meaningful visual works.

Keywords: Design, Visual Creation, Visual Literacy
Once-Daily Oral Sarecycline 1.5 mg/kg/day is Effective for Moderate to Severe Acne Vulgaris: Results from Two 12-Week, Phase 3, Randomized, Double-Blind Clinical Trials
Authors: Moore Angela , Bruce Suzanne , Sadick Neil , Tschen Eduardo , Werschler Philip , Dhawan Sunil , Farsha Douglas , Gold Michael , Guenthner Scott , Kempers Steve , Kircik Leon , Parish Jennifer , Rendon Marta , Rich Phoebe , Stein-Gold Linda , Tyring Stephen , Weiss Robert , Nasir Adnan , Schmitz Carsten , Boodhoo Terry , Kaoukhov Alexandre , Berk David , Cook-Bolden Fran , Grada Ayman
Published: September 2020

Abstract not available.
Molecular Optimization by Capturing Chemist’s Intuition Using Deep Neural Networks
Authors: He Jiazhen , you huifang , Sandström Emil , nittinger eva , Bjerrum Esben Jannik , Tyrchan Christian , Czechtizky Werngard , Engkvist Ola
Published: September 2020

A main challenge in drug discovery is finding molecules with a desirable balance of multiple properties. Here, we focus on the task of molecular optimization, where the goal is to optimize a given starting molecule towards desirable properties. This task can be framed as a machine translation problem in natural language processing, where in our case, a molecule is translated into a molecule with optimized properties based on the SMILES representation. Typically, chemists would use their intuition to suggest chemical transformations for the starting molecule being optimized. A widely used strategy is the concept of matched molecular pairs where two molecules differ by a single transformation. We seek to capture the chemist's intuition from matched molecular pairs using machine translation models. Specifically, the sequence-to-sequence model with attention mechanism, and the Transformer model are employed to generate molecules with desirable properties. As a proof of concept, three ADMET properties are optimized simultaneously: logD, solubility, and clearance, which are important properties of a drug. Since desirable properties often vary from project to project, the user-specified desirable property changes are incorporated into the input as an additional condition together with the starting molecules being optimized. Thus, the models can be guided to generate molecules satisfying the desirable properties. Additionally, we compare the two machine translation models based on the SMILES representation, with a graph-to-graph translation model HierG2G, which has shown the state-of-the-art performance in molecular optimization. Our results show that the Transformer can generate more molecules with desirable properties by making small modifications to the given starting molecules, which can be intuitive to chemists. A further enrichment of diverse molecules can be achieved by using an ensemble of models.
Ultra-Low Molecular Weight Photoswitchable Hydrogelators
Authors: Larik Fayaz , Fillbrook Lucy , Nurttila Sandra , Martin Adam D , Kuchel Rhiannon P. , Taief Karrar Al , Bhadbhade Mohan , Beves Jonathon , Thordarson Pall
Published: September 2020

Photoswitchable arylazopyrozoles 2 and 3 form hydrogels at a concentration of 1.2% (w/v). With a molecular weight of 258.11 g/mol, these are the lowest known molecular weight hydrogelators that respond reversibly to light. Single-crystal X-ray structures show anisotropic aggregation of 2 and 3 is driven by in-plane hydrogen bonding interactions and 𝝅 - 𝝅 stacking. Photoswitching of 2 and 3 from the E- to the Z-form by 365 nm light results in a macrocopic gel→sol transition; nearly an order of magnitude reduction in the measured elastic and loss moduli. Cryogenic transmission electron macroscopy suggests that the 29±7 nm wide sheets in the E-2 gel state narrow to 13±2 nm upon photoswitching to the predominantly Z-2 solution state. In the case of 2, photoswitching is reversible through cycles of 365 nm and 520 nm excitation with little fatigue. The release of a Rhodamine B dye encapsulated in gels formed from 2 and 3 can be accelerated more than 20-fold upon photoswitching with 365 nm light, demonstrating these materials are suitable for light-controlled cargo release.
Procesos de interacción en Instagramers latinoamericanas. El caso de Perú y Colombia durante el 2019
Authors: Gonzalez-Carrion Erika-Lucia , Aguaded Ignacio
Published: September 2020

Con el objetivo de evaluar las formas de interacción en las principales Instagramers de Perú y Colombia, se efectuó un análisis exploratorio de sus perfiles en la plataforma audiovisual Instagram durante el año 2019. Por esta razón, primeramente, se recurre a la herramienta Heepsy para establecer las influenciadoras con mayor injerencia dentro de la plataforma en ambos países y posteriormente, a través de las herramientas de monitoreo Fan Page Karma y Social Blade, determinar un conjunto de variables y parámetros respecto a su interacción. Los resultados visibilizan que el índice de audiencia es mayor para las Instagramers de Colombia que para Perú. Además, se observa una clara tendencia por parte de los públicos digitales en valorar el contenido a través de “me gusta” como muestra de una interacción con él, pero en contraparte, se demuestra una disminución representativa en expresar con palabras y en comentarios sus impresiones respecto a lo que observan; esto queda establecido también en los bajos niveles de compromiso que registran la mayoría de Instagramers.
Analysis of morbidity and mortality of cervical cancer in Zabaikalskii krai
Authors: Bogomazova Tatyana V. , Chimitdorzhieva Tatyana N.
Published: September 2020

Relevance. Currently, noncommunicable diseases are responsible for the majority of deaths worldwide. Cervical cancer (СС) is actual medical and social problem. Comparative analysis of morbidity, mortality and state of oncological care in Zabaikalskii krai and Russian Federation was purpose of this study.

Aim. Estimation of morbidity and mortality from cervical cancer in the Zabaikalskii krai in dynamics over 10 years.

Materials and methods. The assessment was carried out on the basis of an analysis of statistical data concerning the burden of morbidity and mortality from cancer in the territory of the Zabaikalskii krai and the Russian Federation. Statistical analysis was performed using the Statistica 10 software. Standardized indicators were used to analyze morbidity and mortality. Differences were considered statistically significant at an error level of p0.05.

Results. Analysis cervical cancer incidence of the Zabaikalskii krai and the Russian Federation in dynamics from 20072017 (100 000 female population) demonstrates a significant increase in the incidence of cervical cancer. On the territory of the Russian Federation, there is a steady increase on average by 2.26% annually, the growth dynamics over this period amounted to 25.81%, and in 2017 amounted to 15.76. In the Zabaikalskii krai in 2017, the incidence of cervical cancer was 41.54. In dynamics over the past 10 years, this indicator increased by 46.42%, which is significantly higher than in the Russian Federation (p0.01). The analysis of standardized indicators of mortality from cervical cancer in the structure of mortality from cancer in Russia in 2017 amounted to 5.18%, which corresponds to 10th place. Mortality in the first year since diagnosis was 14.6%. In the group of women of reproductive age 3039 years, mortality from cervical cancer was also maximum (23.6%) compared with other age groups. Mortality from cervical cancer in the Zabaikalskii krai was 7.17 in 2017. This indicator is higher than the all-Russian values by 38.41% (p0.01). In dynamics over 10 years, a decrease in mortality in the Zabaikalskii krai by 6.39% is noted.

Conclusion. It should be noted that a significant increase in the incidence of cervical cancer, and a decrease in mortality from this pathology, may indicate some success in the diagnosis and treatment of this pathology. In this regard, the search for new diagnostic, prognostic and predictive markers at this stage is relevant in solving this all-Russian medical and social problem.
Strategi Luar Negeri Dubai Menjadi Sebuah Peradaban Modern (Melalui Kebijakan Luar Negerinya)
Authors: Setiawan Nindyo
Published: September 2020

Located in the Middle East region, Dubai has to face the reality to compete with other countries in a business that only consists of the oil market. However, it was predicted that in the year of 2005, Dubai’s oil resources will be run out. After the establishment of United Arab Emirates (UAE), Dubai has slowly shown its progress significantly. Started as a desert civilization who didn’t have anything into a metropolitan country with all of the majesties which is considered as a world class level, often called as the Singapore of the Middle East. However, the success of Dubai can't be separated from the foreign policy created by its leader, Sheik Mohammed bin Rashid Al Maktoum who is often called as the CEO of Dubai. After pointed as the leader of Dubai Defense Force by his father, Sheikh Rashid, Sheikh Mohammed began to help his father. He finally took the position as Emir of Dubai in 2006 after his brother Maktoum bin Rashid Al Maktoum died. Through this paper, the writer is going explore the foreign policy created by Sheikh Mohammed bin Rashid al Maktoum. The analysis itself is going to use Idiosyncratic Theory created by Margareth Hermann as a theoretical framework.
Fetishism and Sexual Objectification towards African (Black) Women in Modern Society: Analyzing the Portrayal of African Women in the Media
Authors: Bianca Fransisca
Published: September 2020

In the perspective of multicultural feminism, beside society needs to end the subordination of women to men, it also needs to end the subordination of women to fellow women depending on her race, religion, education, etc. Multicultural feminism also emphasizes the acknowledgement of the difference between each woman’s background to understand their issues. Even so, the fact remains that women of color; African women in the case of this paper, still face objectification by society. While considered as possessing the ideal physique to fit men’s sexual desires, African women are still considered subordinate than Caucasian women. This does not only emphasize the portrayal of women as objects to men, but also emphasizes the consideration of women of color being in lower class than Caucasian women. Thus, with consideration to the way African women are portrayed in the media as exemplified by the case analysis in this paper, it could be concluded that African women (and other women of color) are still more often objectified in modern society.
Pengabaian Suku Asli dalam Proses Perdamaian di Kolombia
Authors: Siregar Farhan Helmi
Published: September 2020

Peace talks between the Goverment of Republic of Colombia with Fuerzas Armadas Revolucionarias de Colombia—Ejército del Pueblo (FARC-EP) started from 2011 to 2016, and followed by disarmament and transition phase until 2017. The talks and process have resulted peace agreement between the conflicting sides in 2016, FARC-EP disarmament process, and transitioning the rebels into civilians’ life. Considered as a success by some observers, the peace process is not yet solving the problem about indigenous people affected by an half-century conflict between the goverment and FARC-EP. This paper will examine discourses from perspective of community security which is originated from the concept of human security that involves violent action, and other threats towards indigenous people in Colombia, the Awa, and Wounaan People between 2011 to 2017. The goal of discursive practices on violent action towards indigenous ''people during the peace process in Colombia is to explain the threat to community security in Colombia due to the problem occured in indigenous community
Human Security di Papua pada Masa Pemerintahan Jokowi: Tinjauan terhadap Political Security di Papua
Authors: Yonatan Ignatius
Published: September 2020

The continuing conflict in Papua is a problem that should be given more attention by the current Indonesian government. The problem is not merely a matter of integrity, and economy. However, it is also about human security’s matter, especially, political security in Papua. Until now, Papuans still face different treatment than those in other parts of Indonesia. Violence and abuse of human rights, also other form of cruelty still happen there. As president of Indonesia, Jokowi is expected to be able to solve the political security’s matter in Papua. However, it should be admitted that solving political security’s matter in Papua is not that easy. Nevertheless, Jokowi has shown good intentions to restore Indonesia’s relations with Papua through economic approach. This research will discuss about how human security in Papua under Jokowi with focus on the review of political security in Papua.
Hegemony and Regionalism: Brazil’s Subordination of Argentina through the Formation of Mercosur
Authors: Pratama Aditya
Published: September 2020

Rivalitas strategis antara Brazil dan Argentina di masa Perang Dingin membuat kawasan Amerika Latin relatif tidak kohesif dan tidak terintegrasi. Ketidakbersatuan ini dimanfaatkan oleh Amerika Serikat (AS) dalam rangka mengimplementasikan doktrin Monroe-nya di mana AS perlu fokus atas situasi di Amerika Latin. Sehingga AS pada masa itu dapat membangun hegemoninya di kawasan tersebut misalnya dengan adanya otoritas moral AS atas junta-junta militer di Brazil, Argentina, dan Bolivia. Namun demikian, pasca Perang Dingin AS disibukkan dengan situasi di Timur-Tengah dan Indo-Pasifik, oleh sebab itu prioritasnya terhadap Amerika Latin relatif berkurang. Peristiwa ini dimanfaatkan oleh Brazil dalam rangka mengaktualisasikan keinginannya menjadi kekuatan regional di kawasan tersebut melalui pendirian Mercosur dan memarginalkan kekuatan regional berpotensi lainnya seperti Meksiko dari sebuah kawasan baru yang bernama Amerika Selatan. Penelitian ini berpendapat bahwa tujuan Brazil dibalik pendirian Mercosur adalah tidak hanya untuk kepentingan ekonomi tetapi juga guna menenangkan Argentina dan memasukkan Argentina ke dalam hegemoninya. Dengan menggunakan metode kualitatif, tulisan ini menganalisis upaya-upaya Brazil melalui perspektif sub-sistem regional di mana harus terdapat sebuah pemimpin kawasan dalam proses membangun suatu kawasan baru.
India, Indonesia, Australia ke Tiongkok: Sebuah Studi Mengenai Konsep Sphere of Influence di Era Kontemporer
Authors: Karunia Lazarus Andja
Published: September 2020

Abad ke-21 mendekati akhir dekade keduanya. Polaritas dunia masih terlihat condong ke Washington walaupun banyak yang merasa kekuatan Beijing akan menandinginya. Di lain pihak, kita tidak bisa melupakan reaksi dan strategi para regional power di jalur ekspansi Belt and Road Initiative Tiongkok. New Delhi, Jakarta dan Canberra sudah mulai menunjukkan keinginan mereka untuk bersatu menangkal ekspansi Beijing setidaknya setahun terakhir ini. Pembahasan yang dibawa akan sesekali berfokus pada bagaimana konsep regional hegemony, structural realism, dan sphere of influence pada saat ini sedang digunakan oleh ketiga regionalpower terutama dalam menangkal ekspansi Tiongkok di Laut Natuna Utara. Regional hegemony akan menjelaskan pada kadar tertentu ‘kedaulatan regional’ ketiga negara, structural realism akan menjelaskan alasan realis ketiga negara untuk bersatu, dan sphere of influence akan menjelaskan mengapa proyeksi regionalisme ketiga negara dieksekusi secara terbatas. Riset ini akan mengupas tiga pertanyaan. Mengapa ketiga negara mau bekerja sama? Apakah tiap negara memiliki kontribusi efektif terhadap tujuan mereka bersam
Drug trafficking in the Golden Triangle: The Myanmar problem and ASEAN effectiveness
Authors: Harper Nathan , Tempra Nathan
Published: September 2020

This essay explores the issue of drug trafficking and production in Myanmar to understand the extent of damage this problematic situation has on the South East Asian region and to discuss what steps are being taken by institutions to stem the proliferation of narcotics such as heroin and amphetamines. Myanmar’s turbulent political history and unique geographical position have been explained to garner knowledge on why drug trafficking and production are so closely associated with the nation. The policymaking efforts of the Association of South East Asian Nations (ASEAN) to combat drug trafficking and production in the region have so far been plagued by obstructions such as internal corruption, a lack of multilateral cooperation and insufficient resources. These barriers combine to create policy that it is aligned closer to empty rhetoric than actual physical implementation. The ASEAN and China Cooperative Operations in Response to Dangerous Drugs (ACCORD) agreement has shown signs of a changing tide toward effective policymaking, due mainly to China stepping up to the plate of regional leadership. This essay recommends that in order to successfully fight drug trafficking and production, ASEAN need to establish more realistic and achievable goals with an emphasis on rehabilitation rather than punishment. Furthermore, compliance mechanisms should be put in place by ASEAN so that countries such as Myanmar, who often deviate from the status quo of drug policy, will be reprimanded for doing so in the future. Thus, creating an environment of multilateral cooperation, togetherness and consistency in relation to combatting the illegal drug trafficking and production trade
ASEAN Maritime Security Cooperation to Combat Piracy within Malacca Strait: A Constructivist Perspective and Extra-Regional Actor’s Interests
Authors: Mauludy Raihan Zahirah
Published: September 2020

Sejalan dengan posisi geografis Asia Tenggara yang strategis untuk rute perdagangan, Asia Tenggara dijadikan sebagai target operasi pembajakan. Selat Malaka adalah tempat pembajakan paling berbahaya di Asia Tenggara. Terdapat sejumlah tragedi pembajakan yang terjadi setiap tahun, karena selat ini merupakan wilayah sepertiga aktivitas perdagangan dunia dilakukan dan dilalui oleh ribuan kapal setiap tahunnya. Makalah ini ingin menjawab bagaimana kerjasama keamanan maritim ASEAN memerangi pembajakan di Selat Malaka dengan melibatkan proses sosialisasi dan persuasi. Makalah ini bertujuan untuk mengeksplorasi kerjasama keamanan maritim ASEAN dalam memerangi pembajakan di Selat Malaka, serta membahas proses lengkap terkait interaksi, mekanisme dan kerangka kerja. Makalah ini juga akan membahas tentang peluang aktor luar di ASEAN, dalam menjalankan kepentingan mereka dalam kerjasama keamanan maritim ASEAN. Makalah ini menggunakan teori sosialisasi dan persuasi yang diprakarsai oleh Johnston Checkel, atau dengan kata lain teori mikro dari teori konstruktivisme untuk menghubungkan kerjasama keamanan maritim ASEAN di Selat Malaka dan prosesnya dalam memerangi pembajakan.
Di Balik Ketergantungan Zimbabwe terhadap Investasi Tiongkok Pasca Nasionalisasi Yuan sebagai Mata Uang Zimbabwe
Authors: Rakhman Reza Aulia
Published: September 2020

On December 22nd 2015, President Zimbabwe Robert Mugabe officially declared that Zimbabwe will nationalize Yuan as official national currency. This policy is being done in order to solve default against Zimbabwe's debt to China. In return, China will pay off Zimbabwe's debt. By having this policy, foreign direct investment (FDI) as a foreign aid given by China will impact the economy development of Zimbabwe. This paper will examine Zimbabwe’s interdependence to China’s investment after nationalize Yuan as Zimbabwe’s currency with Theory of Foreign Capital Dependence and Development: A New Direction by Jeffrey Kentor and Terry Boswell