bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Actions of Net Zone Approach in Padel: Validation of the NAPOA Instrument
Authors: Escudero-Tena Adrián , Muñoz Diego , García-Rubio Javier , Ibáñez Sergio J.
Published: February 2022

To carry out research that analyzes performance indicators through observational methodology, it is necessary to have validated tools. The purpose of this study was to design and validate a tool to ascertain the characteristics of the strokes that padel pairs use to reach the net and their consequences in the two subsequent shots of the game. Eleven experts, who had to meet four of the five inclusion criteria established by the researchers, participated in the process. Aiken’s V coefficient and confidence intervals were used to analyze content validity and Cronbach’s α coefficient to calculate reliability. The adequacy and wording of the sixteen variables initially designed were evaluated. Four variables were eliminated due to obtaining values <0.90 in Aiken’s V coefficient in adequacy. The rest of the variables were modified in their wording, according to the qualitative evaluations of the experts, or were considered correct. The reliability of the instrument was acceptable (α = 0.89). The NAPOA instrument is novel, as it is of interest to analyze the characteristics of the strokes that padel players use to achieve the offensive position.
Side Effects of Opioids Are Ameliorated by Regulating TRPV1 Receptors
Authors: Wang Xiaqing , Bao Chongyu , Li Zhenjiang , Yue Lupeng , Hu Li
Published: February 2022

Humans have used opioids to suppress moderate to severe pain for thousands of years. However, the long-term use of opioids has several adverse effects, such as opioid tolerance, opioid-induced hyperalgesia, and addiction. In addition, the low efficiency of opioids in controlling neuropathic pain limits their clinical applications. Combining nonopioid analgesics with opioids to target multiple sites along the nociceptive pathway may alleviate the side effects of opioids. This study reviews the feasibility of reducing opioid side effects by regulating the transient receptor potential vanilloid 1 (TRPV1) receptors and summarizes the possible underlying mechanisms. Blocking and activating TRPV1 receptors can improve the therapeutic profile of opioids in different manners. TRPV1 and μ-opioid receptors are bidirectionally regulated by β-arrestin2. Thus, drug combinations or developing dual-acting drugs simultaneously targeting μ-opioid and TRPV1 receptors may mitigate opioid tolerance and opioid-induced hyperalgesia. In addition, TRPV1 receptors, especially expressed in the dorsal striatum and nucleus accumbens, participate in mediating opioid reward, and its regulation can reduce the risk of opioid-induced addiction. Finally, co-administration of TRPV1 antagonists and opioids in the primary action sites of the periphery can significantly relieve neuropathic pain. In general, the regulation of TRPV1 may potentially ameliorate the side effects of opioids and enhance their analgesic efficacy in neuropathic pain.
Perceived Noise Pollution and Self-Reported Health Status among Adult Population of Bangladesh
Authors: Rahman Md. Mostafizur , Tasnim Farah , Quader Masrur Abdul , Bhuiyan Md. Nafee-Ul-Islam , Sakib Mohammed Sadman , Tabassum Rawnok , Shobuj Ifta Alam , Hasan Lamia , Chisty Musabber Ali , Rahman Farzana , Alam Edris , Islam Abu Reza Md. Towfiqul
Published: February 2022

Despite the public health concern, there is a dearth of research regarding perceived noise pollution and noise-related health status in Bangladesh. This study was carried out to evaluate the noise-related health status among Bangladesh’s adult population. 1386 adult Bangladeshis participated in an online survey. A linear regression model was used to evaluate overall noise-related health status determinants. 91% of the survey population reported noisy environments in their neighborhood, with the majority reporting two types (34%) of noise pollution sources. Road vehicles (38%) and construction activities (24%) were identified as significant source of noise pollution. The Bangladeshis are primarily exposed to noise during school and office hours. Socio-demographic information, perceived noise pollution and individual views towards noise pollution were examined as determinants of noise-related health problems. Females were found to be more impacted than males, and young people also expressed concern about noise pollution’s influence. Residents in mixed-unit buildings exhibited a significant level of noise-related health problems such as deafness, insomnia, heart disease, headache, stress, poor concentration, production loss, fatigue, irritability, heartburn, indigestion, ulcers, and high blood pressure. Noise pollution from road vehicles and industry has been shown to have a negative effect on people’s health. Individuals affected by noise were interested in noise reduction efforts. The findings of this research may aid in the improvement of international, national, and local noise control efforts.
Workaholism and the Enactment of Bullying Behavior at Work: A Prospective Analysis
Authors: Balducci Cristian , Menghini Luca , Conway Paul M. , Burr Hermann , Zaniboni Sara
Published: February 2022

Despite the fact that workaholism and workplace aggressive behavior share many correlates, such as neuroticism, hostility, and negative affectivity, little is known about their relationship, with most evidence on both phenomena coming from cross-sectional studies. In the present study, we contributed to a better understanding of the antecedents of enacted workplace bullying behavior (i.e., perpetration of bullying), and the potential interpersonal implications of workaholism, by investigating their cross-lagged relationship. Data from a two-wave one-year panel study conducted with 235 employees in a national healthcare service organization showed substantial cross-sectional and cross-lagged positive relationships between workaholism and enacted workplace bullying. Whereas Time 1 workaholism was a significant predictor of Time 2 enacted workplace bullying, reversed causation was not supported. To shed light on the role of a potential mechanism explaining the link between workaholism and enactment of bullying, we examined whether job-related negative affect (e.g., anger) mediated their longitudinal relationship. However, whereas increased negative affect from T1 to T2 was positively associated with T2 enacted workplace bullying, the relationship between T1 workaholism and increased job-related negative affect was not significant, contrary to the hypothesized mediation. Taken together, our findings suggest that workaholism may be an important antecedent of enacted workplace bullying. Study limitations and future perspectives are discussed.
The Effect of an After-School Physical Activity Program on Children’s Cognitive, Social, and Emotional Health during the COVID-19 Pandemic in Nova Scotia
Authors: Caldwell Hilary A. T. , Miller Matthew B. , Tweedie Constance , Zahavich Jeffery B. L. , Cockett Ella , Rehman Laurene
Published: February 2022

Children’s physical activity participation declined during the COVID-19 pandemic, and these negative changes could lead to longer-term impacts on children’s cognitive, social, and emotional health. Purpose: To determine parent/caregivers’ perceptions of their children’s cognitive function, peer and family relationships, life satisfaction, physical activity, sleep, positive affect, and global health, before and after participating in the Build Our Kids’ Success (BOKS) programming at after-school programs in Fall 2020. Methods: Parents of children participating in the BOKS programming at after-school programs in Nova Scotia, Canada, were recruited. At baseline, 159 parents completed the National Institutes of Health (NIH) Patient-Reported Outcomes Measures Information System (PROMIS) parent-proxy questionnaire, and 75 parents completed the measures at follow-up. Independent t-tests were used to determine if there were differences between baseline and follow-up Parent Proxy Questionnaire data. Results: All NIH PROMIS outcome variables at baseline and follow-up were within normal limits (Adjusted T-Scores: 46.67 ± 7.15 to 50.04 ± 7.13). There were no significant differences in life satisfaction (t(188) = −1.05, p = 0.30), family relationships (t(189) = 0.31, p = 0.76), cognitive function (t(199) = −1.16, p = 0.25), peer relationships (t(192) = −1.86, p = 0.06), positive affect (t(195) = 0.25, p = 0.81), global health (t(216) = −0.43, p = 0.67), physical activity (t(202) = 0.787, p = 0.732), sleep disturbance (t(193) = 1.72, p = 0.087), or psychological stress (t(196) = 1.896, p = 0.059), from baseline to follow-up. Conclusions: Parent-proxy questionnaires suggested that the BOKS programming had a protective effect on children’s health behaviours and cognitive, social, and emotional health as values remained within normal limits and were not impacted by the public health restrictions during the second wave of the COVID-19 pandemic in Nova Scotia.
Associations between Long-Term Air Pollution Exposure and Risk of Osteoporosis-Related Fracture in a Nationwide Cohort Study in South Korea
Authors: Heo Seulkee , Kim Honghyok , Kim Sera , Choe Seung-Ah , Byun Garam , Lee Jong-Tae , Bell Michelle L.
Published: February 2022

Bone health is a major concern for aging populations globally. Osteoporosis and bone mineral density are associated with air pollution, but less is known about the impacts of air pollution on osteoporotic fracture. We aimed to assess the associations between long-term air pollution exposure and risk of osteoporotic fracture in seven large Korean cities. We used Cox proportional hazard models to estimate hazard rations (HRs) of time-varying moving window of past exposures of particulate matter (PM10), sulfur dioxide (SO2), carbon monoxide (CO), nitrogen dioxide (NO2), and ozone (O3) for osteoporotic fracture in Korean adults (age ≥ 50 years) in the National Health Insurance Service-National Sample Cohort data, followed 2002 to 2015. HRs were calculated for an interquartile range (IQR) increase. Comorbidity and prescription associated with osteoporosis, age, sex, body mass index, health behaviors, and income were adjusted in the models. Effect modification by age, sex, exercise, and income was examined. We assessed 56,467 participants over 535,481 person-years of follow up. Linear and positive exposure-response associations were found for SO2, while PM10 and NO2 showed nonlinear associations. SO2 was associated with osteoporosis-related fracture with marginal significance (HR for an IQR [2 ppb] increase = 1.04, 95% CI: 1.00, 1.09). The SO2 HR estimates were robust in analyses applying various moving windows of exposure (from one to three years of past exposure) and two-pollutant models. The central HR estimate of O3 implied positive associations but was not significant (HR for 0.007 ppm increase = 1.01, 95% CI: 0.97, 1.06). PM10, CO, and NO2 did not show associations. Vulnerable groups by sex, age, exercise, and income varied across air pollutants and there was no evidence of effect modifications. Long-term exposure to SO2, but not PM10, CO, NO2 and O3, was associated with increased osteoporotic fracture risks in Korean adults.
Are Gyms a Feasible Setting for Exercise Training Interventions in Patients with Cardiovascular Risk Factors? An Italian 10-Years Cross-Sectional Survey Comparison
Authors: Vecchiato Marco , Quinto Giulia , Palermi Stefano , Foccardi Giulia , Mazzucato Barbara , Battista Francesca , Duregon Federica , Michieletto Federica , Neunhaeuserer Daniel , Ermolao Andrea
Published: February 2022

Background: Exercise training is a known important prevention and treatment modality in patients with cardiovascular (CV) diseases. However, the CV risk factors in gym users have been poorly studied. The aim of this study was to monitor CV risk factors of gym users over 10 years in order to investigate whether gyms are used settings for secondary disease prevention. Methods: In 2007 and 2017, a cross-sectional research survey was adopted to determine CV risk factors and habits in gym users (18–69 years) of the Veneto region. These data were analyzed and compared with those of PASSI, a national surveillance system of the Italian population. Results: During the last decade, there has been an increase in gym users over 50 years of age and in people with arterial hypertension and hypercholesterolemia. People attending the gym on medical referral are increasing, but they are still few (<10%). When comparing the collected data with PASSI surveillance, most of the CV risk factors are strongly underrepresented in gym users. Conclusion: The prevalence of gym users with CV risk factors is rather low, regardless of age. Physicians still need to encourage and prescribe physical exercise for secondary prevention and treatment of chronic diseases.
Microbial Electrochemical Technologies for Sustainable Nitrogen Removal in Marine and Coastal Environments
Authors: De La Fuente María José , Gallardo-Bustos Carlos , De la Iglesia Rodrigo , Vargas Ignacio T.
Published: February 2022

For many years, the world’s coastal marine ecosystems have received industrial waste with high nitrogen concentrations, generating the eutrophication of these ecosystems. Different physicochemical-biological technologies have been developed to remove the nitrogen present in wastewater. However, conventional technologies have high operating costs and excessive production of brines or sludge which compromise the sustainability of the treatment. Microbial electrochemical technologies (METs) have begun to gain attention due to their cost-efficiency in removing nitrogen and organic matter using the metabolic capacity of microorganisms. This article combines a critical review of the environmental problems associated with the discharge of the excess nitrogen and the biological processes involved in its biogeochemical cycle; with a comparative analysis of conventional treatment technologies and METs especially designed for nitrogen removal. Finally, current METs limitations and perspectives as a sustainable nitrogen treatment alternative and efficient microbial enrichment techniques are included.
A Predictive Analysis of Heart Rates Using Machine Learning Techniques
Authors: Oyeleye Matthew , Chen Tianhua , Titarenko Sofya , Antoniou Grigoris
Published: February 2022

Heart disease, caused by low heart rate, is one of the most significant causes of mortality in the world today. Therefore, it is critical to monitor heart health by identifying the deviation in the heart rate very early, which makes it easier to detect and manage the heart’s function irregularities at a very early stage. The fast-growing use of advanced technology such as the Internet of Things (IoT), wearable monitoring systems and artificial intelligence (AI) in the healthcare systems has continued to play a vital role in the analysis of huge amounts of health-based data for early and accurate disease detection and diagnosis for personalized treatment and prognosis evaluation. It is then important to analyze the effectiveness of using data analytics and machine learning to monitor and predict heart rates using wearable device (accelerometer)-generated data. Hence, in this study, we explored a number of powerful data-driven models including the autoregressive integrated moving average (ARIMA) model, linear regression, support vector regression (SVR), k-nearest neighbor (KNN) regressor, decision tree regressor, random forest regressor and long short-term memory (LSTM) recurrent neural network algorithm for the analysis of accelerometer data to make future HR predictions from the accelerometer’s univariant HR time-series data from healthy people. The performances of the models were evaluated under different durations. Evaluated on a very recently created data set, our experimental results demonstrate the effectiveness of using an ARIMA model with a walk-forward validation and linear regression for predicting heart rate under all durations and other models for durations longer than 1 min. The results of this study show that employing these data analytics techniques can be used to predict future HR more accurately using accelerometers.
Social Networking in Adolescents: Time, Type and Motives of Using, Social Desirability, and Communication Choices
Authors: Tremolada Marta , Silingardi Lucio , Taverna Livia
Published: February 2022

The evolution of digital media has changed the patterns and motives for its use among adolescents and has impacted their communication choices within their family and social networks. The objectives of this study are to understand whether peers communicate through a social network (SN) or by voice and their view of the relative social desirability of these alternatives. After the informant’s consent signature, adolescents completed a series of self-report questionnaires on the use of SN, communication preferences, and social desirability online. Most of the adolescents belonged to the 17–19 age group (83.6%) and were female (68.9%). Adolescents spent more than 3 h/day on Whatsapp and more than 2 h/day on Instagram, while the use of Facebook was on average only 35 min/day. Females used digital media longer than males. Adolescents aged 17–19 years choose more Facebook and voice modes compared to adolescents aged 14 and 16 years. Alternative modes of Whatsapp and voice were chosen more than social networks in their communication strategies, especially for negative topics. Motives for use were, in addition to boredom, related to maintaining one’s social sphere with peers. Some educative considerations were made based on these results.
Determinants of Changes in Women’s and Men’s Physical Activity and Sedentary Behavior across the Transition to Parenthood: A Focus Group Study
Authors: Versele Vickà , Stok Femke Marijn , Dieberger Anna , Deliens Tom , Aerenhouts Dirk , Deforche Benedicte , Bogaerts Annick , Devlieger Roland , Clarys Peter
Published: February 2022

Background: Becoming a parent may cohere with drastic changes in physical activity (PA) and sedentary behavior (SB). A clear understanding of determinants of changes in PA and SB during pregnancy and postpartum is needed to facilitate the development of tailored family-based interventions. Methods: Thirteen focus group discussions targeting determinants of changes in PA and SB behavior were conducted, involving a total of 74 expecting and first-time parents. A semi-structured question guide was used to facilitate the discussions. Results: Four main levels of determinants were identified: the individual (including psychological, situational and biological determinants), interpersonal, environmental and policy level. Some determinants were mentioned to be a barrier (e.g., “barriers to self-care”) while others were a facilitator (e.g., “weight control”). Determinants were related to both PA and SB and applicable during pregnancy as well as postpartum (e.g., “self-regulation”), or only related to one behavior and/or one period (e.g., “feeding baby”). Some were described by both parents (e.g., “parenthood perceptions”), whereas others were mentioned by women (e.g., “PA knowledge”) or men (e.g., “time opportunities”) only. Conclusions: Focus should be given to interventions aimed at improving parents’ self-regulation skills and support on how to cope with interpersonal and situational constraints as well as parenthood perceptions.
Thoron Interference on Performance of Continuous Radon Monitors: An Experimental Study on Four Devices and a Proposal of an Indirect Method to Estimate Thoron Concentration
Authors: Di Carlo Christian , Ampollini Marco , Antignani Sara , Caprio Mario , Carpentieri Carmela , Bochicchio Francesco
Published: February 2022

The performance of continuous radon monitors (CRMs) is usually evaluated under controlled conditions in a radon chamber during calibrations or intercomparison exercises. The impact of thoron on CRMs response is rarely evaluated; in case the evaluation is performed, it is carried out in a controlled atmosphere with relatively constant, homogeneous, and generally high thoron concentrations and very low radon levels. In a real indoor environment, both radon and thoron concentrations are extremely variable, so the thoron interference evaluations reported in the literature are generally not applicable to CRMs used to measure radon concentration indoors. For this reason, an experimental study was carried out with four different CRMs in an indoor environment (an office room) where medium-to-high concentrations of both radon and thoron were expected. Thoron concentration has been separately evaluated throughout two different active monitors. Three CRMs resulted in overestimations of radon concentration by about 10% due to thoron interference, whereas such interference results were negligible for the fourth CRM. However, the thoron interference can also be used to assess thoron concentration by using CRM not specifically designed to do so. Based on the results of this study, an indirect method to assess thoron concentration is indeed proposed, relying on the combination of two identical monitors (one placed right close to the wall and the other one far enough from there).
Loss of Happiness for Land-Expropriated, Urbanised Residents: A Comparison Based on Multiple Groups
Authors: Han Junhui , Huo Zenghui , Sun Xuejia
Published: February 2022

Are land-expropriated, urbanised residents living happily? This question is not only related to the quality of urbanisation but also has important reference for evaluating the reform of the land acquisition system. On the basis of the Chinese General Social Survey data in 2017 and 2018, the HeckProbit model, the ordered probit model and the mediating effect model were used to study the happiness and underlying mechanism of land-expropriated, urbanised residents. The results showed that the older the farmers are, the lower the probability of obtaining urban hukou through land acquisition, and women will be more likely to achieve household registration through land requisition. Education and party status have significant inhibitory effects on hukou conversion through land acquisition. A comparison among multiple groups indicated that the happiness level of each group is ranked as follows: residents who attained urban hukou through education and job recruitment > urban native residents > land-expropriated, urbanised residents > farmers; however, the happiness level of the latter two groups has no significant difference. The propensity score matching method was further used to reduce the endogeneity due to selection bias, and the results were still robust. The lower self-assessment of socioeconomic status indirectly caused the loss of happiness of land-expropriated, urbanised residents. However, the high living expectation ‘suppressed’ the negative effect of land acquisition on happiness to some extent.
Greenspace, Inflammation, Cardiovascular Health, and Cancer: A Review and Conceptual Framework for Greenspace in Cardio-Oncology Research
Authors: Bikomeye Jean C. , Beyer Andreas M. , Kwarteng Jamila L. , Beyer Kirsten M. M.
Published: February 2022

Cardiovascular disease (CVD) is a leading cause of global morbidity and mortality. Cancer survivors have significantly elevated risk of poor cardiovascular (CV) health outcomes due to close co-morbid linkages and shared risk factors between CVD and cancer, as well as adverse effects of cancer treatment-related cardiotoxicity. CVD and cancer-related outcomes are exacerbated by increased risk of inflammation. Results from different pharmacological interventions aimed at reducing inflammation and risk of major adverse cardiovascular events (MACEs) have been largely mixed to date. Greenspaces have been shown to reduce inflammation and have been associated with CV health benefits, including reduced CVD behavioral risk factors and overall improvement in CV outcomes. Greenspace may, thus, serve to alleviate the CVD burden among cancer survivors. To understand pathways through which greenspace can prevent or reduce adverse CV outcomes among cancer survivors, we review the state of knowledge on associations among inflammation, CVD, cancer, and existing pharmacological interventions. We then discuss greenspace benefits for CV health from ecological to multilevel studies and a few existing experimental studies. Furthermore, we review the relationship between greenspace and inflammation, and we highlight forest bathing in Asian-based studies while presenting existing research gaps in the US literature. Then, we use the socioecological model of health to present an expanded conceptual framework to help fill this US literature gap. Lastly, we present a way forward, including implications for translational science and a brief discussion on necessities for virtual nature and/or exposure to nature images due to the increasing human–nature disconnect; we also offer guidance for greenspace research in cardio-oncology to improve CV health outcomes among cancer survivors.
Clinical Manifestations, Diagnosis and Management of Synovial Fistula Associated Lateral Ankle Sprain or Instability: A Retrospective Study of 19 Surgically Confirmed Patients
Authors: Kim Jahyung , Shim Bum-Jin , Yang Jae-Shin , Bat-Ulzii Altanzul , Cho Jaeho
Published: February 2022

We aimed to investigate the preoperative history, clinical manifestations, imaging findings, and postoperative clinical outcomes for patients with surgically confirmed synovial fistula around the ankle joint. 19 consecutive patients who were confirmed to have synovial fistula in the surgical field were enrolled in this study. Medical records of all patients in terms of preoperative details, operative findings, and postoperative outcomes at 1 year after the surgery were retrieved. As a diagnostic modality, the normal saline test or MRI was used. Intraoperatively, the synovial fistula was repaired with the capsuloligamentous repair or additional periosteal augmentation. All patients had a history of ankle sprain prior to symptoms and showed positive results in the saline load test. One patient had recurred symptom after the surgery, so needed a revisional periosteal augmentation. At 1 year follow-up period, the average Foot ankle outcome score was 87.65 and no surgery-related complication was detected. Synovial fistula of the ankle joint needs to be taken into consideration as a possible complication in patients with ankle sprain history and recurrent joint swelling. The saline load test would be useful for its diagnosis, and treatment should be focused on the complete closure of capsular opening along with restoration of its surrounding pathologic conditions.
The Cost-Effectiveness Analysis of the Productivity Measurement and Enhancement System Intervention to Reduce Employee Work-Related Stress and Enhance Work Performance
Authors: Jensen Irene , Arapovic-Johansson Zana , Aboagye Emmanuel
Published: February 2022

Background: The study evaluates the cost-effectiveness of the Productivity Measurement and Enhancement System (ProMes) intervention to reduce employee work-related stress and enhance work performance. Methods: A prospective cohort study was used to undertake the evaluation from a business perspective. Objective workload data and stress were gathered repeatedly over a 17-month period (i.e., before and after intervention). Independent t-test and an interrupted time series (ITS) analysis were used in the analysis. The average cost-effectiveness ratio (ACER) was calculated as a ratio of the average cost of the intervention and the effect sizes of the different outcomes to reflect the average cost per clinician for each unit change in outcome. Results: Based on the results of the ITS analysis, an expenditure of EUR 41,487 was linked with no change in stress levels, according to the ACER for stress. In addition, the expenditures associated with each unit change were EUR 3319 for overall tasks per hour worked, EUR 2761 for visits per hour worked, EUR 2880 for administrative tasks, but EUR 9123 for answering phone calls. Conclusions: ProMes is not cost–effective in terms of work-related stress levels, but the intervention seemed to have increased efficiency in some objective work performance measures, albeit at a relatively high extra cost.
Infant Developmental Outcomes: Influence of Prenatal Maternal–Fetal Attachment, Adult Attachment, Maternal Well-Being, and Perinatal Loss
Authors: Branjerdporn Grace , Meredith Pamela , Wilson Trish , Strong Jennifer
Published: February 2022

Identification of prenatal characteristics that predict later infant development may afford opportunities for early intervention, potentially optimizing childhood development outcomes. The aim of the present study was to examine the effects of selected prenatal factors (maternal–fetal attachment, maternal adult attachment, maternal well-being, and previous perinatal loss) on later infant development. Pregnant women were recruited from two antenatal clinics at one tertiary hospital and asked to complete self-report questionnaires. The Bayley’s Scales of Infant and Toddler Development were then completed one to two years after their baby’s birth. Independent samples t-tests, correlational analyses, and multivariate linear regression models were conducted. Results from 40 dyads revealed that more favorable maternal–fetal attachment, more secure/less anxious maternal attachment, and higher maternal well-being predicted maternal reports of infant adaptive behavior regardless of previous perinatal loss. Infants of women without perinatal loss scored higher in external observer-rated cognitive development compared to infants of women with previous perinatal loss. While further research is required, findings indicate that a mother’s well-being and her relationship with her baby during pregnancy contributes to positive perceptions of her infant’s daily living skills. Supporting the parenting of women with perinatal loss is required to, in turn, promote optimal cognitive development in infants.
The Longevity-Frailty Hypothesis: Evidence from COVID-19 Death Rates in Europe
Authors: Zahran Sammy , Altringer Levi , Prasad Ashok
Published: February 2022

By the end of spring (31 May), the COVID-19 death rate was remarkably unevenly distributed across the countries in Europe. While the risk of COVID-19 mortality is known to increase with age, age-specific COVID-19 death rates across Europe were similarly unevenly distributed. To explain these mortality distributions, we present a simple model where more favorable survival environments promote longevity and the accumulation of health frailty among the elderly while less favorable survival environments induce a mortality selection process that results in lower health frailty. Because the age-related conditions of frailty render the elderly less resistant to SARS-CoV-2, pre-existing survival environments may be non-obviously positively related to the COVID-19 death rate. To quantify the survival environment parameter of our model, we leveraged historic cohort- and period-based age-specific probabilities of death and life expectancies at age 65 across Europe. All variables are significantly correlated with indicators of frailty like elderly dependence on others for personal and household care for a subset of European countries. With respect to COVID-19 death rates, we find significant positive relationships between our survival indicators and COVID-19 death rates across Europe, a result that is robust to statistical control for the capacity of a healthcare system to treat and survive infected persons, the timing and stringency of non-pharmaceutical interventions, population density, age structure, case rates and the volume of inbound international travelers, among other factors. To address possible concerns over reporting heterogeneity across countries, we show that results are robust to the substitution of our response variable for a measure of cumulative excess mortality. Also consistent with the intuition of our model, we also show a strong negative association between age-specific COVID-19 death rates and pre-existing all-cause age-specific mortality rates for a subset of European countries. Overall, results support the notion that variation in pre-existing frailty, resulting from heterogeneous survival environments, partially accounts for striking differences in COVID-19 death during the first wave of the pandemic.
Empathy through the Pandemic: Changes of Different Emphatic Dimensions during the COVID-19 Outbreak
Authors: Baiano Chiara , Raimo Gennaro , Zappullo Isa , Marra Marialaura , Cecere Roberta , Trojano Luigi , Conson Massimiliano
Published: February 2022

Growing evidence suggests that empathy is a relevant psychological trait to face the challenges imposed by the COVID-19 pandemic, but at the present very little is known on whether this multi-dimensional construct has been affected by the pandemic outbreak differently in its separate components. Here, we aimed at filling this gap by capitalizing on the opportunity of having collected data from different self-report measures and cognitive tasks assessing the main dimensions of empathy immediately before the beginning of the global pandemic and about one year later. The results showed a detrimental impact of the pandemic outbreak on empathic social skills but not on both cognitive (perspective-taking) and emotional empathy that instead significantly improved. Thus, reduced empathic social skills could be a weakness to be targeted in psychological interventions to help people cope with the mental health challenges related to COVID-19 pandemic, whereas the ability of understanding another’s mental states and emotions could represent a strength in dealing with the current long-lasting crisis.
Psychometric Qualities of the McMaster Family Assessment Device–General Functioning Subscale for Malaysian Samples
Authors: Cong Chin Wen , Tan Soon Aun , Nainee Sarvarubini , Tan Chee-Seng
Published: February 2022

Family functioning has been associated with psychological well-being and physical health. The 12-item McMaster Family Assessment Device–General Functioning Subscale (FAD-GF) has been widely used to assess individuals’ overall level of family functioning. However, it has shown an inconsistent factor structure across various studies. The present study investigated its psychometric qualities in two studies with two different adult samples in Malaysia. In Study 1 (N = 417, 55.3% females, 19 to 26 years old), exploratory factor analyses were conducted, and four models were found: a three-factor model with 11 items, a two-factor model with 12 items, and one-factor models with six negatively worded items and six positively worded items, respectively. Study 2 (N = 358, 65.1% females, 18 to 60 years old) compared models found in past studies and those found in Study 1 through confirmatory factor analyses on another sample of adults. Among the six competing models, the two-factor model with three positively worded and three negatively worded items (i.e., FAD-GF-SF) is preferable because it did not require modification and showed a clear-cut result of goodness of fit. The subscales demonstrated satisfactory internal consistency. In conclusion, the FAD-GF-SF is a useful instrument for measuring family functioning in the Malaysian context.
HOMA Index, Vitamin D Levels, Body Composition and Cardiorespiratory Fitness in Juvenile Obesity: Data from the CHILT III Programme, Cologne
Authors: Fraemke Annika , Ferrari Nina , Friesen David , Haas Fabiola , Klaudius Marlen , Mahabir Esther , Schmidt Lisa , Joisten Christine
Published: February 2022

Juvenile obesity is associated with insulin resistance, among other comorbidities. In the pathogenesis of insulin-resistance-related diseases, including obesity and diabetes, Vitamin D deficiency is very common. Therefore, the relationship between insulin resistance, body composition, vitamin D level, and cardiorespiratory fitness in obese children and youth were analyzed based on the Children’s Health InterventionaL Trial III project, Germany. Data on vitamin D levels and homeostatic model assessment (HOMA) indices were available from 147 participants (52.4% female; 90.5% obese; 12.3 ± 2.3 years, BMI: 30.5 ± 5.2 kg/m2, BMI standard deviation score (BMI-SDS): 2.52 ± 0.46). Vitamin D levels correlated negatively with the HOMA index, BMI, BMI-SDS, abdominal circumference, and body fat percentage but positively with relative cardiorespiratory fitness (p < 0.05 in each case). In the backward stepwise linear regression analysis, body fat (in kg; β = 0.403) and vitamin D levels (β = −0.154) explained 21.0% of the variance in the HOMA index. In summary, increased body fat and lower vitamin D levels are associated with increased HOMA indices in overweight and obese children and adolescents. In order to prevent potential negative consequences, including the development of manifest Type 2 diabetes, a healthy lifestyle with a vitamin-D-enriched diet and more time spent outdoors should be promoted.
Changes in Bone Mineral Density and Trabecular Bone Score over Time between Vegetarian and Non-Vegetarian Middle-Aged and Older Women: A Three-Year Retrospective Medical Record Review
Authors: Chuang Tzyy-Ling , Koo Malcolm , Chuang Mei-Hua , Lin Chun-Hung , Huang Chin-Huan , Wang Yuh-Feng
Published: February 2022

The effect of a vegetarian diet on bone health remains controversial. This retrospective medical record review compared changes in bone mineral density (BMD) and trabecular bone score (TBS) between vegetarian and non-vegetarian middle-aged and older women who underwent two general health examinations (T1 and T2) that were approximately three years apart. Generalized estimating equations were used to compare the change in lumbar spine and bilateral hip BMD and TBS over time. At T1, the mean age of the patients was 56.6 years (standard deviation 9.7 years) and the mean interval between T1 and T2 was 2.7 years. For women aged 40–55 years, compared with non-vegetarians, vegetarians were significantly associated with a larger reduction in lumbar spine BMD (p < 0.001) and left hip femoral neck BMD (p = 0.015) over the three-year interval. On the contrary, changes in BMD were not significant at any site in women aged ≥ 56 years. Moreover, the changes in BMD and TBS over the three-year interval did not significantly differ between vegetarian and non-vegetarian women aged 65–90 years. In conclusion, for women aged 40–55 years, vegetarian diets reduced bone quantity, as measured by BMD, but not bone quality, as measured by TBS.
Risk Assessment of Indoor Air Quality and Its Association with Subjective Symptoms among Office Workers in Korea
Authors: Jung Dayoung , Choe Youngtae , Shin Jihun , Kim Eunche , Min Gihong , Kim Dongjun , Cho Mansu , Lee Chaekwan , Choi Kilyong , Woo Byung Lyul , Yang Wonho
Published: February 2022

The 2014 Time-Use Survey of Statistics Korea revealed that office workers are increasingly spending more than eight hours at work. This study conducted an exposure assessment for office workers in Korea. Indoor and outdoor air pollutants were measured in offices. A self-administered questionnaire was employed to determine work information, indoor air quality (IAQ) awareness, and subjective symptoms for 328 workers. Indoor air concentrations for measured air pollutants were below IAQ guideline values. The average concentrations of target air pollutants did not show significant differences except for benzene, which had relatively a higher concentration in national industrial complexes. The indoor benzene, ethylbenzene, and acetaldehyde concentrations were higher in offices where workers were having dry eye, ophthalmitis, and headache symptoms. This study provides reference values to manage IAQ in offices, suggesting that if the benzene concentration exceeds 4.23 μg/m3 in offices, it could cause dry eye symptoms. Considering the increasing working hours for office workers and health effects, workers’ exposure to indoor pollutants should be reduced. In addition, the IAQ was heavily influenced by outdoor air levels and various indoor sources. Therefore, in areas with relatively high air pollution, greater monitoring and management is required considering the influence of outdoor air quality.
Occurrence, Distribution, and Risk of Organophosphate Flame Retardants in Sediments from Jiulong River Estuary and Adjacent Western Taiwan Strait, China
Authors: Cai Ling , Shi Yuwei , Pan Chenyuan , Zhu Feng , Wang Siqi , Dai Juanjuan , Yang Ming , Ma Jing
Published: February 2022

Organophosphate ester flame retardants (OPFRs) are widely prevalent in the environment and are of significant concern because of their potential toxicity to human health and wildlife. In this study, the concentration, frequency, spatial distribution, potential sources, and ecological risks of OPFRs in sediments from the Jiulong River estuary and the adjacent western Taiwan Strait were investigated. Concentrations of four of the five studied OPFRs were between <LOD and 36.6 ng/g. The distribution of all OPFRs, except 2-Ethylhexyl diphenyl phosphate (EHDPP), remained highly consistent with hydrological (salinity) trends. Furthermore, a significantly positive correlation between EHDPP and total concentrations suggested that it may be the dominant contaminant at both sites. Principal element analysis indicated multiple sources of OPFRs, which were categorized as emissions from road runoff and surface traffic, effects of atmospheric deposition and hydrologic conditions, and a combination of industrial and population effects. Ecological risk indicates that tris (chloroethyl) phosphate (TCEP) and triphosphate ester (2,3-dibromopropyl) (TDBPP) have almost no risk, tris (clorisopropyl) phosphate (TCPP) generally has low risk, while EHDPP has moderate risk with the highest value of 0.487 in the sediments from both sites. Meanwhile, TCPP and TCEP exhibit lower theoretical health risks but are still not negligible. Overall, this work provides data to support global pollutant studies and facilitate the implementation of pollutant control strategies.
Novel Loss of Function Variant in BCKDK Causes a Treatable Developmental and Epileptic Encephalopathy
Authors: Boemer François , Josse Claire , Luis Géraldine , Di Valentin Emmanuel , Thiry Jérôme , Cello Christophe , Caberg Jean-Hubert , Dadoumont Caroline , Harvengt Julie , Lumaka Aimé , Bours Vincent , Debray François-Guillaume
Published: February 2022

Branched-chain amino acids (BCAA) are essential amino acids playing crucial roles in protein synthesis and brain neurotransmission. Branched-chain ketoacid dehydrogenase (BCKDH), the flux-generating step of BCAA catabolism, is tightly regulated by reversible phosphorylation of its E1α-subunit. BCKDK is the kinase responsible for the phosphorylation-mediated inactivation of BCKDH. In three siblings with severe developmental delays, microcephaly, autism spectrum disorder and epileptic encephalopathy, we identified a new homozygous in-frame deletion (c.999_1001delCAC; p.Thr334del) of BCKDK. Plasma and cerebrospinal fluid concentrations of BCAA were markedly reduced. Hyperactivity of BCKDH and over-consumption of BCAA were demonstrated by functional tests in cells transfected with the mutant BCKDK. Treatment with pharmacological doses of BCAA allowed the restoring of BCAA concentrations and greatly improved seizure control. Behavioral and developmental skills of the patients improved to a lesser extent. Importantly, a retrospective review of the newborn screening results allowed the identification of a strong decrease in BCAA concentrations on dried blood spots, suggesting that BCKDK is a new treatable metabolic disorder probably amenable to newborn screening programs.
Vaccines for Human Schistosomiasis: Recent Progress, New Developments and Future Prospects
Authors: Molehin Adebayo J. , McManus Donald P. , You Hong
Published: February 2022

Schistosomiasis, caused by human trematode blood flukes (schistosomes), remains one of the most prevalent and serious of the neglected tropical parasitic diseases. Currently, treatment of schistosomiasis relies solely on a single drug, the anthelmintic praziquantel, and with increased usage in mass drug administration control programs for the disease, the specter of drug resistance developing is a constant threat. Vaccination is recognized as one of the most sustainable options for the control of any pathogen, but despite the discovery and reporting of numerous potentially promising schistosome vaccine antigens, to date, no schistosomiasis vaccine for human or animal deployment is available. This is despite the fact that Science ranked such an intervention as one of the top 10 vaccines that need to be urgently developed to improve public health globally. This review summarizes current progress of schistosomiasis vaccines under clinical development and advocates the urgent need for the establishment of a revolutionary and effective anti-schistosome vaccine pipeline utilizing cutting-edge technologies (including developing mRNA vaccines and exploiting CRISPR-based technologies) to provide novel insight into future vaccine discovery, design, manufacture and deployment.
Biopolymer Composites: Synthesis, Properties, and Applications
Authors: Díez-Pascual Ana M.
Published: February 2022

Petroleum-based plastics can be found everywhere in our habitual life in diverse applications such as automobiles, aerospace, and medical science [...]
Clinical Application Perspectives of Lung Cancers 3D Tumor Microenvironment Models for In Vitro Cultures
Authors: Wieleba Irena , Wojas-Krawczyk Kamila , Krawczyk Paweł , Milanowski Janusz
Published: February 2022

Despite the enormous progress and development of modern therapies, lung cancer remains one of the most common causes of death among men and women. The key element in the development of new anti-cancer drugs is proper planning of the preclinical research phase. The most adequate basic research exemplary for cancer study are 3D tumor microenvironment in vitro models, which allow us to avoid the use of animal models and ensure replicable culture condition. However, the question tormenting the scientist is how to choose the best tool for tumor microenvironment research, especially for extremely heterogenous lung cancer cases. In the presented review we are focused to explain the key factors of lung cancer biology, its microenvironment, and clinical gaps related to different therapies. The review summarized the most important strategies for in vitro culture models mimicking the tumor–tumor microenvironmental interaction, as well as all advantages and disadvantages were depicted. This knowledge could facilitate the right decision to designate proper pre-clinical in vitro study, based on available analytical tools and technical capabilities, to obtain more reliable and personalized results for faster introduction them into the future clinical trials.
Cytokine-Induced JAK2-STAT3 Activates Tissue Regeneration under Systemic or Local Inflammation
Authors: Kim Young Kyu , Lee Ju Young , Suh Han Na
Published: February 2022

We investigated the immune response mechanisms under systemic and local inflammation using mouse models whereby lipopolysaccharide (LPS) was administered intraperitoneally to induce systemic inflammation, and epicutaneous sensitization with ovalbumin was used to induce local inflammation. LPS increased the immune cell infiltration in the cardiac muscle near the aorta, alveoli, hepatic sinusoid, renal interstitium, and the submucosal layer of the duodenum. Similarly, ovalbumin increased the abundance of macrophages in the skin. Both LPS and ovalbumin induced NF-κB p65 and IκBα phosphorylation, as well as the expression of NF-κB target genes (TLR4, IL6, and TNFα). Additionally, both LPS and ovalbumin led to an increase in the absolute IL-1β, IL-6, and TNFα serum levels and cytokine-related janus kinase 2 (JAK2)/signal transducer and activator of transcription 3 (STAT3) phosphorylation. Moreover, the activated JAK2/STAT3 signaling increased the number of Ki67-positive cells (proliferating cells) and development pathway target gene expression (regeneration) in the inflammation models. In conclusion, LPS and ovalbumin increase immune cell infiltration in tissues, NF-κB activation, cytokine levels in serum, cytokine-stimulated JAK2/STAT3 signaling, and tissue regeneration.