bluuebunny/crossref_metadata_2025 huggingface dataset:
The mechanosensitive ion channel PIEZO1 promotes satellite cell function in muscle regeneration
Authors: Hirano Kotaro , Tsuchiya Masaki , Shiomi Akifumi , Takabayashi Seiji , Suzuki Miki , Ishikawa Yudai , Kawano Yuya , Takabayashi Yutaka , Nishikawa Kaori , Nagao Kohjiro , Umemoto Eiji , Kitajima Yasuo , Ono Yusuke , Nonomura Keiko , Shintaku Hirofumi , Mori Yasuo , Umeda Masato , Hara Yuji
Published: November 2022

Muscle satellite cells (MuSCs), myogenic stem cells in skeletal muscles, play an essential role in muscle regeneration. After skeletal muscle injury, quiescent MuSCs are activated to enter the cell cycle and proliferate, thereby initiating regeneration; however, the mechanisms that ensure successful MuSC division, including chromosome segregation, remain unclear. Here, we show that PIEZO1, a calcium ion (Ca2+)-permeable cation channel activated by membrane tension, mediates spontaneous Ca2+influx to control the regenerative function of MuSCs. Our genetic engineering approach in mice revealed that PIEZO1 is functionally expressed in MuSCs and thatPiezo1deletion in these cells delays myofibre regeneration after injury. These results are, at least in part, due to a mitotic defect in MuSCs. Mechanistically, this phenotype is caused by impaired PIEZO1-Rho signalling during myogenesis. Thus, we provide the first concrete evidence that PIEZO1, a bona fide mechanosensitive ion channel, promotes proliferation and regenerative functions of MuSCs through precise control of cell division.
Moral Disagreement and Practical Direction
Authors: Francén Ragnar
Published: November 2022

Whenever A judges that x-ing is morally wrong and B judges that x-ing is not morally wrong, we think that they disagree. The two standard types of accounts of such moral disagreements both presuppose that the class of moral wrong-judgments is uniform, though in different ways. According to the belief account, the disagreement is doxastic: A and B have beliefs with conflicting cognitive contents. This presupposes “belief-uniformity”: that the content of moral concepts is invariant in such a way that, whenever A believes that x-ing is morally wrong and B believes that x-ing is not morally wrong, their beliefs have mutually inconsistent contents. According to the attitude account, moral disagreements are non-doxastic: A and B have clashing practical attitudes. This presupposes “attitude-uniformity”: that moral judgments are always accompanied by, or consist of, desire-like attitudes. Consequently, neither account is available if both uniformity-claims are rejected – as e.g., various forms of content-relativism do. This paper presents a new non-doxastic account of deontic moral disagreement, consistent with the rejection of both uniformity-claims. I argue first, that even if deontic moral judgments are not desires, and are not always accompanied by desires, they have practical direction in the same sense as desires: they are attitudes that one can act in accordance or discordance with. Second: deontic moral disagreement can be understood as clashes in practical direction: roughly, A and B morally disagree if, and only if, some way of acting is in accordance with A’s judgment but in discordance with B’s.
The Rent Tax Is Too Damn Low
Authors: Matthew Jeffers
Published: November 2022

Economists and philosophers discuss taxation in the context of the prevailing tax base. This prevailing tax base primarily consists of levies on earned income, capital, and consumption. In the optimal tax literature, economists find that this tax base possesses a problematic tradeoff between equity and efficiency. This tax base is also controversial amongst moral philosophers because it diminishes the principle of labor ownership. I explore a tax base that does not possess these two drawbacks and hence sidesteps problems with the current tax base raised both by optimal tax theorists and moral philosophers. Even partial replacement of the current tax base with the proposed tax base would increase efficiency, improve equity, and preserve labor ownership.
Forgiving the Mote in Your Sister’s Eye
Authors: Lippert-Rasmussen Kasper
Published: November 2022

Many philosophers analyzing standing to blame have argued that a hypocrite can lack standing to blame someone even if what that person did is blameworthy, and that standingless, hypocritical blame is pro tanto morally wrongful. Philosophers have yet to address the issue of standing to forgive. In this article, I defend two main claims. I argue first that if these two claims about blame are true, then so are the two corresponding claims about forgiveness: a hypocritical forgiver can lack standing to forgive someone for an act even if there are reasons to hold that this act is forgivable, and standingless, hypocritical forgiveness is pro tanto morally wrongful. I then argue, separately, that these two claims about forgiveness are true.
Neurological, Cognitive, and Clinical Biomarkers of Lewy Body Dementia Subtypes: A Literature Review
Authors: Ansar Muhammad A. , Soni Tanveer S.
Published: November 2022

Introduction: Diagnosing the etiology underlying dementia symptoms can be difficult because of the broad nature of shared cognitive impairments across dementia subtypes. Therefore, we sought to differentiate the cognitive profiles of Alzheimer’s disease (AD) from vascular dementia (VaD) and Lewy body dementia (LBD).
Methods: PubMed, ScienceDirect, Web of Science, Google Scholar, and PsychINFO were searched for studies comparing the cognitive profile of AD to those of VaD and LBD along the domains of memory, language, and executive function.
Results: Short-term and episodic memory were more severely impaired in AD than VaD and LBD. Semantic memory was more impaired in AD than LBD, but it was similarly impaired in AD and VaD. Semantic fluency was worse in AD than in VaD, and phonemic fluency was worse in AD compared to VaD and LBD. Naming was more impaired in AD compared to VaD and LBD. Executive function impairments were similar or less severe in AD relative to VaD and LBD.
Discussion: Findings may be explained through neuropathological correlates of each disease. Tau proteins targeting the medial temporal lobes and synaptic loss in prefrontal cortices in AD may explain greater memory deficits in AD relative to VaD and LBD. In those with AD, the temporal lobes undergo greater atrophy than in those with VaD and LBD, possibly contributing to the greater semantic fluency impairments in AD. Greater white matter loss in frontal lobes in VaD may be a reason for a worse phonemic fluency in VaD relative to AD. Executive function impairments may be attributable to more deep white matter hyperintensities in those with VaD and more dopaminergic dysfunction of the basal ganglia in those with LBD relative to those with AD.
Conclusion: Understanding the cognitive profiles that differentiate AD from VaD and LBD would aid in more efficient and accurate diagnoses of dementia etiologies. Diagnoses could be further improved by using cognitive assessment in addition to neural and physiological measures. This knowledge may help identify individuals at risk of developing dementia, helping clinicians intervene early and prevent progression to severe stages.
Practical Logic and Optimization Path of the Effectiveness of Teaching Methods in Ideological and Political Theory Courses
Authors: Zhao Yu , Dai Yanjun
Published: November 2022

Since the Party Central Committee has explicitly requested the running of excellent ideological and political theory courses, the teaching methods of ideological and political theory courses have become a major topic of discussion in academic circles. A gap remains between the current teaching methods of ideological and political theory courses and those in the new era. In order to improve the nurturing effect of key courses, it is necessary to study the basic logic of its effectiveness enhancement from the perspective of practice. In the new era, it is essential to take the spirit from the series of important speeches of the Party and national leaders on ideological and political theory courses as guidance, draw on the effective teaching ideas of Comenius that reflect “fun,” “convenience,” and “thoroughness,” closely combine the teaching practice, as well as select and apply the teaching methods based on the concept of three “combinations” and two “innovations,” i.e., combining students, teachers’ teaching styles, and teaching contents; and innovating and practicing the integrated teaching method of diversified integration as well as the new teaching method of media technology-integrated smart classroom.
Applying Communicative Language Teaching in Classroom English Language Lesson Curriculum
Authors: Cui Jie
Published: November 2022

This article provides us a specific classroom English language lesson curriculum designed for CLT, attached with a brief lesson plan and some relevant teaching materials. In the introduction, this article first explains the different English teaching methods coming through the last century and the conception and burgeoning of the CLT approach in language teaching, followed by its primary principles as presented by different scholars. Thereafter, the rationales for each activity and the reasons for the choices within the lesson plan are elaborated in detail. Last but not least, the article further evaluates the strengths and weaknesses of the lesson plan, including the method used, activity types, choice of text, etc.
Practice and Exploration of Mixed Teaching of Microelectronics
Authors: Liu Jianqiao , Zhai Zhaoxia , Wei Haichao , Wang Yang , Jin Guohua , Fu Ce , Wang Xinnian , Bi Sheng
Published: November 2022

The mixed teaching mode plays an increasingly important role in stimulating students’ interest and autonomy in learning, and strengthening students’ learning ability. The full integration of mixed teaching mode and microelectronics teaching can not only achieve the teaching objectives smoothly, but also enable students to deepen their understanding and memory of relevant knowledge with the help of diversified and interesting teaching methods. Therefore, this paper takes the microelectronics course as an example to practice and explore the effective ways to carry out the mixed teaching mode. Teachers should not make full use of online and offline teaching resources, but also actively improve the traditional assessment systems. Through the continuous improvement of the practicality of online and offline teaching content, an easy-to-complex teaching method with a coherent content structure can be adopted to stimulate students’ learning motivation, improve their enthusiasm for participation, and lay a solid foundation for further improvements in the teaching of microelectronics technology.
Exploiting Influential Factors in Teaching Oriented Towards the Development of Learners’ Capacity
Authors: Tuan Le Khanh
Published: November 2022

The article focuses on teaching in the direction of developing learners’ competencies through the influence of four factors, namely knowledge, skills, attitudes, and situations. Previous studies have shown that properly exploiting these four factors will contribute to effectively reaching the teaching goals, that is, creating the best capacity for learners. Therefore, this study has selected an approach to the problem of improving teaching quality in the direction of developing learners’ capacity. This involved putting the elements of knowledge, skills, attitudes, and teaching situations in the same interactive relationship and to find ways to exploit them most effectively. Using this approach, educational managers should influence the construction of curriculum content (knowledge), create appropriate teaching conditions and environments (situations), establish a mechanism for academic freedom, and relate schooling to life to train learners in skills and attitudes. Teachers can exploit all four factors in the teaching process to improve teaching quality. Using such an approach, a questionnaire was designed to carry out an educational survey with 394 respondents (including 112 graduate students of educational management and 282 pedagogical students living and studying in 41/63 provinces of Vietnam). The survey results affirmed a number of observations and assessments about the current situation of teaching in the direction of developing the learners’ capacity in Vietnam. Solutions to improve the effectiveness of these activities are proposed.
Alternative Digital Credentials: UAE’s First Adopters’ Assessment and Evaluation Part (2)
Authors: Samar El-Farra
Published: November 2022

Despite the wealth of research on full credentials assessments, standardized approaches are still scarce. This is even more threatening to the acceptance of higher education alternative digital credentials. To address this threat, validated and transparent assessments and evaluation processes are of paramount importance. This study is a continuum to our previous review on the pedagogical program analysis, design, development, and implementation. This paper reviews, assesses and evaluates the alternative digital credential offering case study. We review the development and administration of seven requirements and assessment tools used to evaluate students’ performance and use Kirkpatrick’s model to evaluate the effectiveness of the alternative credential offered. The predominantly clinical-based assessment tools and assessment decision criteria are reviewed in detail in this paper, allowing educators to leverage the outcome of this work. Results: The reviewed alternative digital credential case study in the human thorax and extremities from medical imaging has achieved Kirkpatrick level three, as evident in results, particularly from clinical assessments and clinical site viva-voce. When introducing a new competency-based assessment, professional standards can be used as a reference point to develop Behavioral Marker System rubrics. The Ebel method in calculating the cut score, which reflects expert judgment, should be considered when developing competency-based rubrics. Standardization of at least the top common technical and NTS is possible when researchers consider international collaboration by publishing comprehensive methodologies, frameworks, and results. This paper is unique as we are unaware of any publication on alternative digital credentials combining medical imaging and technical and non-technical skills within entrustable professional task assessment, verification, and program evaluation.
Piedras Vivas, KARINA SKVIRSKY-AGUILERA N.A.S.A.L. / GUAYAQUIL / 11 AGOSTO - 25 SEPTIEMBRE
Authors: Kronfle Rodolfo
Published: November 2022

El trabajo de Karina Skvirsky-Aguilera pondera la particularidad y complejidad del individuo en oposición a los esencialismos con que se abordan los discursos étnicos y de raza. Partiendo de aquello el texto explora la idea de identidades dislocadas y fluctuantes que enarbola su obra frente a nociones homogeneizadoras y reductivas cada vez más inviables en el mundo contemporáneo. La artista invita a repensar conceptos como “filiación cultural” que hoy resultan problemáticos en sociedades progresivamente descalzadas de sus propios imaginarios de raíces, origen y procedencia, y que sin embargo son moneda corriente en la ideología y la arena política.
Quemar la Tierra, Rosell Messeguer y Fabiano Kueva
Authors: Cazar Katya
Published: November 2022

Rosell Messeguer:

Messeguer busca indagar en una arqueología minera, en la huella milenaria de las capas minerales que nos cuentan la historia subterránea, lo acontecido en la tierra, en las cenizas. Las obras de la artista seleccionadas en esta curaduría narran aquello que ha trascendido en la naturaleza soterrada– relatan la extracción minera desde un ángulo crítico y, a nivel poético, propone una arqueología de espacios abandonados; la postal desértica provocada por el hombre que atraviesa excavaciones de ansiada riqueza, donde el mito en busca de tesoros, genera una mitología desoladora.

Fabiano Kueva:

El fuego es desde siempre la vida, con su energía potente  y efímera; crea y destruye, hace y deshace, abriga y desaparece; el fuego en esta obra de Fabiano Kueva, es el instrumento de un acto performático, donde los resultados son de una impresión profunda, que deja vestigios en la memoria; es también un gesto poético y político, pues al quemar un texto no hay vacío, sino huella, el artista deconstruye la capa superficial del texto y su lingüística primaria, la deja caer y elabora una marca que denota otra semiótica de lo que no cambia y nos conduce a otro texto que demanda un punto de fuga, las imágenes del video son estáticas variables del tiempo en la urbe caótica y errante.
The Great Woman Singer: Gender and Music in Puerto Rican Music. By Licia Fiol-Matta. Durham and London: Duke University Press, 2017. 291 pages.
Authors: Calle-Poveda  Abstract Ana
Published: November 2022

Licia Fiol-Matta's book bridges psychoanalytic approaches to sound, a detailed listening to vocal performances (pitch, arrangements, silences, vocalization, range), and a particularly feminist archival acumen. In this way, she points to instances in which the thinking voice of these great women singer lures, appears and pushes their audience to think. The thinking voice sometimes hides a deep sense of psychoanalytic "nothingness", nada. By repositioning their stories and their voices, this unique and original contribution by Licia Fiol-Matta is itself a thinking voice that will surely resonate across fields.
SHARING INNOVATION – THE KEY TO SUCCESSFUL EDUCATION
Authors:   University of Plovdiv „Paisiy Hilendarski“, Plovdiv, Velcheva Ivelina , Shopova Vera ,   University of Plovdiv „Paisiy Hilendarski“, Plovdiv
Published: November 2022

The present work is dedicated to the presentation of good educational practices, including methods and means of implementing innovations in the educational process. Exemplary school projects are presented, which are based on the principles of the STEM approach, combined with the use of digital tools from various fields. These project activities are suitable for implementation in the learning process both in face-to-face and distance learning. The innovative practices presented are in line with a large part of the recommendations set out in the framework for the learning skills needed in the 21st century (Learning & Innovation Skills – 4Cs). They enable the development of communication and collaboration skills, the creation of digital content, the development of critical thinking and problem solving, as well as the development of creativity and innovation. The described methods and tools are used in the preparation of teachers in various qualification courses conducted by the Department for Qualification and Professional Development of Pedagogical Specialists at Paisiy Hilendarski Polytechnic, Plovdiv. The teaching practices presented are based on the results of a three-year study of already trained teachers, who try them daily in the learning process and notice their positive impact on students.
PRESENTATION OF COMPONENTS AND SEQUENCE OF THE INNOVATIVE METHODOLOGY „MAKEY MODULE“ TO THE CDL MODEL, IMPLEMENTED BY PROJECT-BASED WORK IN THE BULGARIAN LANGUAGE AND LITERATURE IN GRADE 4
Authors:   University of Plovdiv „Paisiy Hilendarski“, Plovdiv, Karadimitrova Rumyana
Published: November 2022

The article presents an in-depth study of literature related to modern digital technologies and methods that are used within the framework of the author’s innovative methodology „Module Makey“ — part of the CDL Model. The sequence of the methodology, which is intended for implementation through projectbased work in the Bulgarian language and literature classes in the fourth grade, is described in detail. Makey Makey technology, Scratch visual-block programming language, Easi-Speak Microphone digital microphones, Edublogs web-based platform, Flipped classroom method are used. An author’s web-based platform „Teacher’s Blog“ has been developed, the purpose of which is to support the learning process. Its content includes both information about the studied content and guidelines for the students’ work. The experimental work of the Makey Module in practice is not the subject of the current article, but its results show that it increases both students’motivation to learn and their basic digital, linguistic, and contextual competences.
LESSON „AN ANSWER TO THE BIG QUESTION: WHAT WILL HAPPEN TO PEOPLE IF GOOD WORDS DISAPPEAR?“
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Atanasov Valentin , Kalinova Maria ,   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Todorieva Vangelia ,   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Nikolova Dafina ,   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev
Published: November 2022

It is a real challenge to study in the future, not in the past trough Big Questions. Big Questions encourage students to suggest theories, to discuss, to work in a team and think critically. They are linked with big ideas, constantly rethinking, suggestions are made, answers are grounded, backed with evidence. They are aimed at deep reflection, meaningful discussion, long study, new understanding, personal experience, previous education as well as use of significant connections. They are often open and complex. They may not receive an answer while working on them. We, the Team for support of personal development in First Primary School „St. Cyril and St. Methodius“ have been faced in front of many unknowns. How to ask big questions? How to set our goals for a project with a big question? How to create a story to engage students? How to plan and organise group work? How to trace the progress? How to plan work with students?The article is based on a lesson in class 5 and it is only a small example of how we use big questions. With it we would like to promote the little-known pedagogical practice giving us another opportunity for innovative education. Our Big Question lesson was dedicated to kind words that we must not let go because they are vital and necessary in our everyday life. The appearance of this article is inspired by the National Kind Words Day held in Bulgaria on 14th April 2022.
OBESITY – A PANDEMIC THAT IS TALKED ABOUT QUIETLY
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Baneva Elena , Dinev Iliya ,   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev
Published: November 2022

In this report, Ms. Baneva and Mr. Dinev want to give voice to a problem that is spoken of quietly and present our practice for solving this problem to adolescents. Obesity is an official disease defined as such in 1998 by the WHO and is due to excessive accumulation of adipose tissue in a person’s body. This is a complex disease that leads to a number of other complications and diseases. The good practice we share with this report is a binary lesson on „Obesity – a pandemic that is talked about quietly“, conducted with students in 1bth grade and students from 2nd grade in an all-day form of training in St. Constantine and Helena Primary School. „Cyril and Methodius“, Gotse Delchev.
STIMULATING THE CREATIVE THINKING AND ACTIVITY OF STUDENTS DURING PRACTICAL TRAINING CLASSES AND EXTRACURRICULAR ACTIVIES
Authors:   „St. Cyril and St Methodius“ Secondary School, Sindel, Varna, Prashtilova Boryana
Published: November 2022

This article presents an author’s concept for teaching theoretical knowledge to students during mandatory practical classes and during extracurricular classes with the school’s culinary club „Eating and health“ in the years 2020/2021 and 2021/2022 by making a theoretical overview, covering topics that are not included in the curriculum for practical training: 1. Rules when selecting and combining main products and additional ingredients when preparing new bakery and culinary products; 2. Quality assessment and safety when preparing new bakery and culinary products; 3. Methods and stages of inventing a new product in bread production and culinary. Experimental work with students from 9th, 10th and 11th grade is described, carried out in the kitchen of „St. Cyril and St. Methodius“ Secondary School, Sindel, municipality Avren, region Varna. The process of creating three scientific projects on this topic by students in 9th and 10th grade is described. Conclusions have been drawn about the development of the future professionals’ creative potential and increasing their competitive value by improving multiple personal and professional qualities.
KNITTING A SCARF BY HANDS – A WAY FOR DEVELOPMENT OF CREATIVE THINKING AND STUDENTS’ IMAGINATION
Authors:   First Primary School „St. Cyril and St. Methodius“, Gotse Delchev, Materova Ana
Published: November 2022

If you capture all students ‘attention with something that activates all their sences, imagination and creative thinking-then they would be able to assimilate new skill better and follow the instructions more easily. The innovative method of knitting a scarf by hand allows students through their personal work to make something that can always be used. Knitting a scarf is a unique way to reduce emotional stress among students and stimulate the process of learning and creative thinking. Knitting develops patience and it is important for students during class work. Knitting a scarf allows students to be creative in solving problems, lets them improve their current ways of thinking and behaviour.
CHARACTERIZATION, CRYSTAL STRUCTURE, ANTICANCER AND ANTIOXIDANT ACTIVITY OF NOVEL N-(2-OXO-2-(10H-PHENOTHIAZIN-10-YL) ETHYL)PIPERIDINE-1-CARBOXAMIDE
Authors: Doddagaddavalli M.A. , Bhat S.S. , Seetharamappa J.
Published: November 2022

A new compound, N-(2-oxo-2-(10H-phenothiazin-10-yl)ethyl)piperidine-1-carboxamide (PTZ-PIP) was synthesized and characterized by Fourier transform infrared spectroscopy (FT-IR), nuclear magnetic resonance spectroscopy (1H and 13C NMR) and mass spectrometry. The molecular structure of the compound (PTZ-PIP) was confirmed by single-crystal X-ray crystallographic studies. The compound (PTZ-PIP) was crystallized in a monoclinic crystal system with a space group of C2. The anticancer and antioxidant activity of the compound was investigated.
Kualitas pengiriman dan loyalitas pelanggan GoFood: Peran mediasi kepuasan pelanggan
Authors: Hernando Hendrick , Nugroho Jati
Published: November 2022

Pembahasan mengenai kualitas pengiriman masih jarang dilakukan dalam studi layanan pesan antar makanan online. Studi ini menguji pengaruh langsung kualitas pengiriman terhadap loyalitas dan pengaruh tidak langsungnya melalui peran mediasi kepuasan pelanggan. Sejumlah 125 orang pelanggan GoFood di Madiun ikut terlibat. Teknik Partial Least Squares (PLS) diaplikasikan dalam proses evaluasi model konseptual dan diperoleh signifikansi atas pengaruh tidak langsung kualitas pengiriman terhadap loyalitas, namun tidak untuk pengaruh langsungnya. Hasil PLS mengindikasikan peran mediasi penuh kepuasan pelanggan pada hubungan kualitas pengiriman dan loyalitas. Studi sebelumnya berfokus pada kualitas aplikasi pemesanan, sementara studi ini memberikan pemahaman mengenai peran kualitas pengiriman dalam studi pesan antar makanan online terkini. Akhirnya, studi ini menyarankan kepada penyedia layanan untuk membangun loyalitas pelanggan melalui ketepatan waktu pengiriman.
Geleneksel et üretimi ve tüketimine alternatif: Et analogları
Authors: KÜNİLİ İbrahim Ender , DİNÇ Selin , ÇOLAKOĞLU Fatma
Published: November 2022

Son yıllarda popülaritesi artan ve yeni ürün grupları arasında yer alan et analogları, çoğunlukla bitkisel proteinlerin hammadde olarak kullanıldığı ve son ürüne eti andıran formun kazandırılmasına dayalı ürünlerdir. Et analogları üretiminde baklagillerden yağlı tohumlara, buğdaydan alglere kadar birçok bitkisel kaynak hammadde olarak kullanılabilmekte, hammadde özelliklerine göre aroma arttırıcı ve renk verici gibi katkı ilavesi yapılarak ürüne istenilen özellikler kazandırılabilmektedir. Nihai ürün formunda et benzeri özellikler elde etmek için tüm hammaddeler ve katkı maddeleri geleneksel ve/veya modern işleme teknikleri ile işlenir. Bu işleme teknikleri arasında ekstrüzyon, yaygın olarak kullanılan ve kabul edilen bir yöntem olarak bilinmektedir. Et analoglarının hayvansal ürünlere ikame olarak tüketici tarafındaki kabul edilebilirliği, hammadde ve katkılar ile kullanılan üretim tekniğinin ürüne kazandırdığı kalite özelliklerine göre şekillenmektedir. Yakın gelecekte et analoglarının tüketim alışkanlıklarında yaygın yer bulacağı öngörülmektedir. Bu nedenle, üretime katılan bileşenler üzerine araştırmaların artması, üretim teknolojilerinin kullanımının yaygınlaşması ve geliştirilmesi ile üretime yönelik yasal düzenlemelerin yapılması kaçınılmaz olacaktır. Bu çalışmada yeni bir gıda olarak et analoğu ve kavramı, üretimin başlangıcından tüketici kabulüne kadar geniş bir perspektiften ele alınmıştır.
Is heart-type fatty acid binding protein (H-FABP) a valid marker of arterial stiffness in patients with systemic sclerosis?
Authors: Öztürk Ercüment , Yılmaz Sema , Tuncez Abdullah , Aygül Nazif , Ünlü Ali , Vatansev Hüsamettin
Published: November 2022

Background/Aim: Both micro- and macro-vascular involvement has been researched in systemic sclerosis (SSc) for many years. In this study, the relationship of arterial stiffness with heart-type fatty acid binding protein (h-FABP), which is well-accepted as a cardiac marker, was investigated for the first time.

Methods: In this case-control study, 40 patients diagnosed with SSc between the ages of 18 and 65 were included. Thirty healthy individuals of similar age and gender were included as the control group. Patients were excluded from the study if they had cardiovascular risk factors, active infections, and/or malignancies. Along with detecting biochemical markers in the blood, results from methods, such as 24-h blood pressure Holter recordings, pulse-wave velocities (PWV), and echocardiograms (ECHO) were obtained from patients.

Results: The homocysteine mean level was higher in the patient group than in the control group (P < 0.001). H-FABP and asymmetric dimethylarginine (ADMA) means were similar between the two groups (P = 0.286 and P = 0.340, respectively). Vascular parameters, including mean arterial pressure (MAP), augmentation index normalized to the 75 /min heart rate (AIx @ 75), and PWV were also similar between the two groups (P = 0.498, P = 0.382 and P = 0.180, respectively).

Conclusion: It can be concluded that no ongoing myocardial damage occurs based on normotensive Holter findings, normal h-FABP levels, and ECHO findings in our patients. It is suggested that vasodilatory treatments, such as pentoxifylline and calcium channel blockers, which the patients receive for SSc treatment due to Raynaud Syndrome, may protect them from hypertension and therefore offer protection from myocardial damage.
On connection of asymptotic formulas for the counting function and for the characteristic numbers of a compact positive operator
Authors: Voytickiy V.
Published: November 2022

Let operator G be compact positive operator acting in separable Hilbert space. According with theorem of Hilbert-Schmidt its characteristic numbers μn are positive finite multiple with unique limit point at infinity. In spectral problems of mathematical physics such numbers, as a rule, have power (Weyl’s) asymptotic. Sometimes it is more convenient to use asymptotic of counting function N(r) that is equal to number (taking into account the multiplicity) of characteristic numbers μn in the interval (0; r). For single eigenvalues recalculation of asymptotic formulas is a simple exercise. We prove several theorems on connection between asymptotic of μn and N(r) for an arbitrary compact positive operator G.
On periodic solutions of linear parabolic problems with nonlocal boundary conditions
Authors: Solonukha O.
Published: November 2022

A linear parabolic equation with nonlocal boundary conditions of the BitsadzeSamarsky type is considered. The existence and uniqueness theorem of the periodic solution is proved.
Is there an association between 30-day mortality and adrenaline infusion rates in post-ROSC patients? A retrospective observational analysis
Authors: Owen Peter , Sherriff Martyn
Published: November 2022

Introduction: Revised guidelines for the management of cardiac arrest have placed greater emphasis on early defibrillation and closed chest compressions; subsequently there has been a significant rise in the number of patients gaining a return of spontaneous circulation (ROSC).
As a consequence, emergency medical services have realised the importance of therapies delivered during this phase of care. In some Trusts this includes the use of inotropic agents to augment the cardiovascular system and maintain adequate cerebral and coronary perfusion pressures to mitigate
the effects of post-cardiac arrest syndrome. Currently, limited evidence exists with regards to the efficacy of such treatments in the pre-hospital phase.Methods: Retrospective observational analysis of out-of-hospital cardiac arrest patients who received an adrenaline infusion
by critical care paramedics. Infusion rates, time of call (ToC) to ROSC and 30-day mortality were compared.Results: Over a 2-year period, 202 patients were recorded as having an adrenaline infusion commenced. Of these, 25 were excluded as they did not meet criteria or had incomplete
data and 22 were excluded as the infusion was stopped at scene; 155 patients were admitted to hospital. There were no survivors in the non-shockable group and three survivors in the shockable group at 30 days. A rare events analysis found no relationship between infusion rate, ToC to ROSC
and 30-day mortality (Wald chi2, 1.37).Conclusion: Commencement of adrenaline infusions in post-ROSC was associated with significant 30-day mortality, especially in non-shockable rhythms. Further research is needed to elucidate whether this intervention has any benefit in the post-ROSC
patient.
Permissive hypotension compared to fluid therapy for the management of traumatic haemorrhage: a rapid review
Authors: Clarke Rebecca , Dippenaar Enrico
Published: November 2022

Background: Haemorrhage and subsequent hypovolemia from traumatic injury is a potentially reversible cause of cardiac arrest, as interventions can be made to increase circulatory volume and organ perfusion. Traditionally, intravenous (IV) fluid therapy is recommended for all
patients who have experienced a haemorrhagic emergency. There has been some argument, however, that this may not be the most effective treatment as isotonic fluids can dilute coagulation factors and further stimulate bleeding. Permissive hypotension, also known as hypotensive resuscitation
within the context of damage control resuscitation, is a method of managing haemorrhagic trauma patients by restricting IV fluid administration to allow for a reduced blood pressure. It is important to evaluate and compare current research literature on the effects of both permissive hypotension
and fluid therapy on patients suffering from traumatic haemorrhage.Methods: A rapid review was conducted by systematically searching and identifying literature to narratively compare permissive hypotension and fluid therapy. Searches were carried out across two databases to find
relevant primary research containing quantitative data that provide contextual and statistical evidence to achieve the aim of this review. Papers were narratively synthesised to produce key themes for discussion.Results: The database searches identified 125 records, 78 from PubMed
and 47 from ScienceDirect. Eleven duplicates were removed, and 114 titles screened. Ninety-four records were initially excluded and nine more after abstract review. Eleven papers were critiqued using Benton and Cormack's framework, with eight articles included in the final review.Conclusion:
Permissive hypotension may have a positive impact on 30-day mortality, when compared with fluid resuscitation methods, however there is evidence to suggest that hypotensive resuscitation may be more effective for blunt force injuries. Some studies even suggest a reduction in the treatment
cost when reducing fluid volumes. Penetrating injuries are usually more likely to be a compressible source of haemorrhage within which haemorrhage control can be gained much more easily. There are recommendations for the use of permissive hypotension in both compressible and non-compressible
injuries. It is difficult at this time to draw definitive conclusions for the treatment of every case related to traumatic haemorrhage given the variability and unpredictability of trauma.
Creating virtual communities of practice for ambulance paramedics: a qualitative evaluation of the use of Project ECHO in end-of-life care
Authors: Hodge Andrew , Manson Jane , McTague Laura , Kyeremateng Sam , Taylor Paul
Published: November 2022

Introduction: Ambulance services play a key role in the recognition and care of patients nearing their end of life, yet are expected to recognise and manage these complex presentations often with limited education. Paramedics operate across large geographical areas, meaning education
delivery is challenging. Yorkshire Ambulance Service implemented Project Extension for Community Healthcare Outcomes (ECHO), which is the creation of virtual communities of practice to address this problem and increase access to specialist supervision, education and sharing of practice. We
undertook a service evaluation of the programme and interviewed paramedics about their experiences with ECHO.Methods: Semi-structured interviews were conducted with eight ambulance clinicians who took part in the end-of-life care (EoLC) ECHO programme. Thematic analysis and coding
was undertaken to identify and develop the emerging themes.Results: This study identified three key themes: programme structure, factors influencing engagement and professional impact. The provision of a virtual community of practice through Project ECHO was a unique and highly
valued experience, which was accessible and allowed for networking, peer support and sharing of practice. The concept of a ripple effect was reported in disseminating learning across the wider team.Conclusion: The development of virtual communities of practice as a novel educational
intervention has the potential to transform clinical supervision and ongoing education for ambulance clinicians who are often isolated by the nature of ambulance services that cover large regions.
TANGGUNG JAWAB NAFKAH KELUARGA DARI ISTRI YANG BEKERJA MENURUT KOMPILASI HUKUM ISLAM (KHI) DAN HUKUM ADAT (Studi Penelitian di Kota Lhokseumawe)
Authors: Syafitri Nadya , Hamdani Hamdani , Ramziati Ramziati
Published: November 2022

Peran wanita saat ini memang terus mengalami perkembangan, tidak hanya dalam ruang lingkup keluarga tapi juga di bidang sosial, politik bahkan juga di bidang ketenagakerjaan. Bagaimana perbandingan terhadap tanggung jawab nafkah keluarga dari istri yang bekerja menurut Kompilasi Hukum Islam (KHI) dan Hukum Adat di Kota Lhokseumawe? Bagaimana akibat hukum yang ditimbulkan tanggung jawab nafkah keluarga dari istri bekerja? Metode pendekatan yang digunakan dalam penelitian ini adalah pendekatan yuridis sosiologis. Perbandingan terhadap tanggung jawab nafkah keluarga dari istri yang bekerja. Menurut Kompilasi Hukum Islam (KHI) pemberian nafkah keluarga dari istri tetap diperbolehkan dengan tujuan untuk membantu suami mencari nafkah. Dalam hukum adat, selama istri masih bekerja untuk membantu suami tidak pernah dilarang. Perbandingan Kedua hukum ini di Kota Lhokseumawe, yaitu pengaturan peran suami wajib memberi nafkah kepada keluarga sedangkan peran istri sunnah, dan akibat hukum yang ditimbulkan yaitu hilangnya peran sebagai suami dan hilangnya peran istri untuk tunduk kepada suami serta hilangnya tanggungjawab Istri. Akibat hukum yang ditimbulkan tanggung jawab nafkah keluarga dari istri bekerja menurut Kompilasi Hukum Islam (KHI) yaitu hukumnya sunnah jika membantu suami, makruh jika kebutuhannya telah dipenuhi oleh suaminya,Haram hukumnya jika mencari nafkah bagi dirinya sendiri. Akibat hukum yang ditimbulkan menurut hukum adat yaitu Kebutuhan wanita di wilayah kerja, ketaatan kepada suami berkurang kurangnya menjaga kehormatan diri dan Intensitas dalam mengurus rumah tangga berkurang.
PENERAPAN PENGGUNAAN HAK ATAS TANAH UNTUK INDUSTRI DI PROPINSI SULAWESI TENGAH
Authors: Sahlan Sahlan , Ayyub Rusli , K Armin , Bekka Abraham
Published: November 2022

Penguasaan atas tanah, baik oleh perorangan, secara bersama ataupun penguasaan oleh negara, hanya dilakukan dan hanya boleh dilakukan, apabila tujuannya adalah bagi sebesar-besarnya kemakmuran dan keadilan rakyat atau bagi sebanyak-banyaknya kesejahteraan bangsa dan negara. Penelitian hukum yang diselenggarakan, telah dilakukan dengan pendekatan yuridis normatif dan bersifat deskriptif analitis. Dan disoroti terutama dari segi teknik perundang-undangan. Pengumpulan data dilakukan lebih menitikberatkan pada studi dokumentasi di perpustakaan. Kunjungan ke lapangan lebih ditujukan untuk pengecekan penerapan hukum positif dan untuk menemukan persoalan-persoalan dalam implikasinya. Temuan hasil penelitian menunjukkan adanya persoalan yang berkaitan dengan belum  tuntasnya penyusunan konseptual dalam tahap perencanaan, penyusunan kebijakan dan pengaturan, yang disebabkan faktor kelemahan kualitas para perencana dan pejabat hukum. Kelemahan termaksud telah menimbulkan persoalan kesalahfahaman dan ketidaktepatan dalam  menerapkan konsepsi, sehingga kebijakan pengaturan yang disusunnya serta pelaksanaannya banyak menyimpang dari yang diharapkan dan bahkan telah menimbulkan disharmonisasi dalam masyarakat. Produk yang dicapai adalah sedemikian rupa kurang baiknya, sehingga akan memerlukan upaya keras yang sulit dan memerlukan waktu yang panjang untuk menserasikannya kembali. Kondisi dan persoalan semacam itu  terjadi dan ditemukan baik dalam masalah ‘penguasaan tanah oleh negara dalam Hukum Pertahanan Nasional, maupun dalam masalah ‘penguasaan tanah di kawasan industri’. Di bidang pembangunan industri, pemilihan pendekatan dilakukan dengan lebih mengutamakan kepentingan perusahaan kecil, menengah dan koperasi di bidang agro bisnis dan agro industri, tanpa mengabaikan kehadiran dan peranan para pengusaha besar. Dan dalam program pengadaan tanah untuk pengembangan suatu kawasan, seyogyanya dikembangkan pendekatan kemitraan, sedemikian rupa sehingga kepentingan rakyat banyak dan perlindungan baik hak-hak rakyat atas tanah dapat lebih terperhatikan.
EFEKTIVITAS PENANGGULANGAN PENGGUNAAN KNALPOT RACING BAGI PENGENDARA KENDARAAN BERMOTOR
Authors: Firmansyah Tedy , Puspitosari Hervina
Published: November 2022

Penelitian ini bertujuan untuk menjelaskan kenapa masih banyak penggunaan knalpot racing dan menjelaskan tentang bagaimana efektivitas penanggulangan di Satuan Lalu Lintas Polisi Resort Jombang. Hal ini dilatar belakangi oleh hasil observasi penulis di lapangan serta didukung data penindakan knalpot racing di wilayah jombang selama 3 tahun  terakhir terjadi peningkatan dari tahun 2019 sampai 2020 mengenai pelanggaran penggunaan knalpot racing yang melebihi batas decibel yang telah ditentukan serta tidak memenuhi kelayakan teknis dan layak jalan. Dengan mengkaji salah satunya Undang-Undang Nomor 22 Tahun 2009 tentang Lalu Lintas dan Angkutan Jalan. Inti dari adanya Undang -Undang Lalu Lintas dan Angkutan Jalan ialah terciptanya kondisi lalu lintas yang aman,tertib dan taat ketika berkendara. Metode Penelitian yang penulis gunakan dalam penulisan ini yaitu penelitian yuridis empiris yakni jenis penelitian hukum sosiologis yang juga dapat disebut sebagai penelitian lapangan, dengan menyebarkan kuesioner dalam bentuk google form yang dibagikan pada grup Facebook komunitas racing selain itu didukung dengan wawancara langsung dengan tokoh masyarakat. Mengkaji tentang ketentuan hukum yang berlaku serta apa yang terjadi dalam kenyataan di masyarakat. Hasil dari penelitian ini adalah Terdapat kendala internal yang dialami polisi Satuan Lalu Lintas Polisi Resort Jombang, diantaranya kurangnya sosialisasi kepada masyarakat, Selain kendala internal, juga terdapat kendala eksternal rendahnya tingkat kesadaran hukum pengemudi kendaraan bermotor roda dua yang menggunakan knalpot racing, dan terdapat upaya preventif maupun upaya represif yang dilakukan pihak kepolisian.
ANALISIS YURIDIS TERHADAP BUDAYA HUKUM MASYARAKAT TERHADAP PEMBAGIAN HARTA WARISAN DI KABUPATEN PIDIE
Authors: Nidal Ahmad
Published: November 2022

Salah satu permasalahan yang sering terjadi di dalam masyarakat bahkan diperdebatkan adalah berkaitan dengan waktu pelaksanaan pembagian harta waris atau kapan waktunya pembagian harta waris tersebut dapat dilaksanakan. Padahal di dalam hukum Islam dikenal dengan sebuah asas yang disebut dengana asas Ijbari.  Asas ini menggariskan sebuah panduan bahwa pembagian harta warisan dapat dibagi manakala si pewaris meninggal dunia. Dan dengan meninggalnya pewaris, maka harta warisan tersebut secara otomatis telah beralih kepada ahli waris yang ditinggalkannya. Hasil penelitian menunjukkan bahwa budaya hukum yang dijalankan oleh masyarakat di Kabupaten Pidie adalah melakukan pembagian harta warisan dengan hukum adat atau musayawarah.
Analisis Putusan Mahkamah Syariah Takengon Nomor 19/Jn/2020/Ms-Tkn Tentang Zina Dalam Qanun Aceh Nomor 6 Tahun 2014 Hukum Jinayat
Authors: Tamarsah Tamarsah , Faisal Faisal , Hamdani Hamdani
Published: November 2022

Menurut Pasal 1 Ayat (26) Qanun Aceh Nomor 6 Tahun 2014 tentang Hukum Jinayat, zina adalah persetubuhan antara laki-laki dengan perempuan tanpa ikatan perkawinan dengan kerelaan kedua belah pihak. Terdapat satu kasus tentang jarimah zina yang dilakukan oleh terdakwa I dan terdakwa II yang mereka sudah ada ikatan perkawinan (menikah) namun terhadap terdakwa tersebut Jaksa Penuntut Umum menuntut terdakwa tersebut melanggar Pasal 33 ayat (1) Jo Pasal 37 ayat (1) Qanun Hukum Jinayat karena telah melakukan jarimah zina. Dan terhadap kasus tersebut dalam Perkara Nomor 19/JN/2020/Ms.Tkn Majelis Hakim menjatuhkan amar putusan bahwa terdakwa I dan terdakwa II terbukti bersalah melakukan jarimah Khalwat.Tujuan dari penelitian Tesis ini yaitu untuk mengetahui dan menganalisis ketentuan hukum terhadap jarimah zina dan jarimah khalwat menurut hukum Islam dan qanun Aceh nomor 6 tahun  2014 tentang hukum jinayat, penerapan hukum pada putusan perkara nomor 19/JN/2020/MS/Takengon, dan pertimbangan hakim dalam menjatuhkan putusan perkara nomor 19/JN/2020/Ms/Takengon.Metode penelitian yang digunakan dalam penelitian ini adalah yuridis normatif, dengan pendekatan Kasus dan Pendekatan Perundang-Undangan. Sumber data dalam penelitian ini terbagi menjadi 3 (tiga), yaitu bahan hukum primer, bahan hukum sekunder, dan bahan hukum tersier, serta penelitian ini bersifat prespektif.            Berdasarkan hasil penelitian, dalam hukum Islam terdapat perbedaan hukuman yaitu pezina yang sudah menikah di cambuk sebanyak seratus kali dan dirajam dengan batu sedangkan pezina yang masih lajang dihukum dengan dicambuk sebanyak seratus kali dan diasingkan selama satu tahun. Sedangkan menurut Qanun Aceh tidak membedakan antara pezina yang menikah dengan yang lajang dan hanya mendapat hukuman seratus kali cambukan. Penerapan hukum oleh Majelis Hakim pada perkara nomor 19/JN/2020/MS.Tkn tidak sesuai dengan fakta dipersidangan. Pertimbangan Hakim dalam menjatuhkan putusan nomor 19/JN/2020/MS.Tkn terdapat kekeliruan karena Majelis Hakim tidak menerapkan mekanisme yang diatur dalam Pasal 37  ayat (1) Qanun Aceh Nomor 6 Tahun 2014 tentang Hukum Jinayat.Disarankan agar dalam Qanun Aceh Hukum Jinayat juga perlu dibuat perbedaan hukuman antar pelaku jarimah yang sudah menikah dengan pelaku jarimah yang belum menikah. Disarankan agar Majelis Hakim lebih teliti dalam menerapkan pasal yang sesuai dengan fakta di persidangan. Disarankan agar Majelis Hakim dalam mempertimbangkan fakta dipersidangan harus dengan ketelitian dan tidak mengenyampingkan ketentuan yang khusus yang terdapat dalam Qanun Aceh.