bluuebunny/crossref_metadata_2025 huggingface dataset:
PROPOSTAS DE MELHORIAS PARA AUMENTAR A CAPACIDADE PRODUTIVA E QUALIDADE DOS PRODUTOS EM UMA EMPRESA DE EMBALAGENS FLEXÍVEIS
Authors: Fernandes Cesar Augustus , Santos Monique Pozzi Cordeiro do , Rodrigues Karen Cristina Grilo , Faber Cleverson , Santis Sandra Helena da Silva de
Published: December 2024

O presente artigo propõe a análise de uma empresa de embalagens flexíveis, que não possui procedimentos de trabalho e controle da produção, fato prejudicial no julgamento de seus resultados. Ressalta a importância de realizar um gerenciamento utilizando métodos científicos, com auxílio de ferramentas e metodologias de gestão da qualidade, para a melhora no controle dos processos e auxílio nas tomadas de decisões. O desenvolvimento da pesquisa aborda a identificação dos problemas por meio de um estudo de caso na empresa, utilizando a ferramenta Diagrama de Ishikawa para definição de causas raízes, contando com o engajamento dos colaboradores e da alta gestão para criação de propostas de melhoria que auxiliem no melhor desempenho da empresa. Sustenta a relevância de promover uma estrutura gerenciada de forma organizada e simplificada com base na aplicação da ferramenta 5S no processo produtivo e a manutenção e controle dos resultados por meio do Ciclo PDCA. Por fim, destaca o quanto a aplicação das metodologias de gestão da qualidade pode promover avanços significativos nos processos da empresa, despertando uma cultura de crescimento contínuo, fortalecendo-se no mercado, evidenciando a importância dessas metodologias para a eficiência e competitividade.
ATUAÇÃO DO (A) ENFERMEIRO (A) NA DETECÇÃO PRECOCE DA HIPERTENSÃO GESTACIONAL E PRÉ-ECLAMPSIA NA ATENÇÃO PRIMÁRIA
Authors: Santana Adriele Santos de , Menezes Juliana Lopes
Published: December 2024

A hipertensão gestacional e a pré-eclâmpsia são causas significativas de morbimortalidade materno-infantil, podendo resultar em complicações graves se não forem detectadas precocemente. Este estudo aborda a atuação do enfermeiro na identificação precoce dessas condições durante o pré-natal. Objetivo: Analisar a atuação dos enfermeiros na Atenção Primária à Saúde (APS) na detecção precoce da hipertensão gestacional e pré-eclâmpsia, destacando estratégias para prevenir complicações materno-fetais. Metodologia: Trata-se de uma revisão integrativa de literatura realizada em bases como BVS, SciELO e LILACS. Foram analisados 26 artigos e diretrizes relevantes publicados nos últimos dez anos. Resultados: O estudo revelou que a assistência pré-natal sistematizada e humanizada permite identificar fatores de risco precocemente, melhorar os desfechos maternos e fetais e prevenir complicações graves. A consulta de enfermagem mostrou-se essencial para monitoramento clínico, exames complementares e orientação das gestantes.
The key role of atmospheric absorption in the Asian summer monsoon response to dust emissions in CMIP6 models
Authors: Zhao Alcide , Wilcox Laura J. , Ryder Claire L.
Published: December 2024

Abstract. We investigate the Asian summer monsoon (ASM) response to global dust emissions in the Coupled Model Intercomparison Project Phase 6 (CMIP6) models, which is the first CMIP to include an experiment with a doubling of global dust emissions relative to their preindustrial levels. Thus, for the first time, the inbuilt influence of dust on climate across a range of climate models being used to evaluate and predict Earth's climate can be quantified. We find that dust emissions cause a strong atmospheric heating over Asia that leads to a pronounced energy imbalance. This results in an enhanced Indian summer monsoon (ISM) and a southward shift of the western Pacific Intertropical Convergence Zone (ITCZ), consistent across models, with the strength of the ISM enhancement increasing with the magnitude of atmospheric dust shortwave absorption, driven by dust optical depth changes. However, the east Asian summer monsoon response shows large uncertainties across models, arising from the diversity in models' simulated dust emissions and in the dynamical response to these changes. Our results demonstrate the central role of dust absorption in influencing the ASM and the importance of accurate dust simulations for constraining the ASM and the ITCZ in climate models.
Multi-fold increase in rainforest tipping risk beyond 1.5–2 °C warming
Authors: Singh Chandrakant , van der Ent Ruud , Fetzer Ingo , Wang-Erlandsson Lan
Published: December 2024

Abstract. Tropical rainforests rely on their root systems to access moisture stored in soil during wet periods for use during dry periods. When this root zone soil moisture is inadequate to sustain a forest ecosystem, they transition to a savanna-like state, losing their native structure and functions. Yet the influence of climate change on ecosystem's root zone soil moisture storage and the impact on rainforest ecosystems remain uncertain. This study assesses the future state of rainforests and the risk of forest-to-savanna transitions in South America and Africa under four Shared Socioeconomic Pathways (SSP1-2.6, SSP2-4.5, SSP3-7.0, and SSP5-8.5). Using a mass-balance-based empirical understanding of root zone storage capacity (Sr), defined as the maximum volume of root zone soil moisture per unit area accessible to vegetation's roots for transpiration, we project how rainforest ecosystems will respond to future climate changes. We find that under the end-of-the-21st-century climate, nearly one-third of the total forest area will be influenced by climate change. As the climate warms, forests will require a larger Sr than they do under the current climate to sustain their ecosystem structure and functions, making them more susceptible to water limitations. Furthermore, warming beyond 1.5–2 °C will significantly elevate the risk of a forest–savanna transition. In the Amazon, the forest area at risk of such a transition grows by about 1.7–5.8 times in size compared to the immediate lower-warming scenario (e.g. SSP2-4.5 compared to SSP1-2.6). In contrast, the risk growth in the Congo is less substantial, ranging from 0.7–1.7 times. These insights underscore the urgent need to limit the rise in global surface temperature below the Paris Agreement to conserve rainforest ecosystems and associated ecosystem services.
Transient Attracting Profiles in the Great Pacific Garbage Patch
Authors: Kunz Luca , Griesel Alexa , Eden Carsten , Duran Rodrigo , Sainte-Rose Bruno
Published: December 2024

Abstract. A major challenge for cleanup operations in the Great Pacific Garbage Patch is the daily prediction of plastic concentrations that allows identifying hotspots of marine debris. Lagrangian simulations of large particle ensembles are the method in use and effectively reproduce observed particle distributions at synoptic scales 𝒪(1000 km). However, they lose accuracy at operational scales 𝒪(1–10 km), and operators regularly experience differences between predicted and encountered debris accumulations within the garbage patch. In Lagrangian methods, it would be common to ask this question: where do objects go as they follow the current? Here, we take a different approach and instead ask this question: which locations attract material? The recently developed concept of Transient Attracting Profiles (TRAPs) provides answers because TRAPs uncover the most attracting regions of the flow. TRAPs are the attracting form of hyperbolic Objective Eulerian Coherent Structures and are computable from the instantaneous strain field on the ocean surface. They describe flow features which attract drifting objects and could facilitate offshore cleanups that are currently taking place in the Great Pacific Garbage Patch. However, the concept remains unapplied since little is known about the persistence and attraction of these features, specifically within the Pacific. Therefore, we compute a 20-year dataset of daily TRAP detections from satellite-derived mesoscale velocities within the North Pacific subtropical gyre. We are the first to track these instantaneous flow features as they propagate through space and time. It allows us to study the life cycle of TRAPs, which can range from days to seasons and lasts an average of 6 d. We show how long-living TRAPs with lifetimes beyond 30 d intensify and weaken over their life cycle, and we demonstrate that the evolution stage of TRAPs affects the motion of nearby surface drifters. Our findings indicate that, at the mesoscale, operators in the Great Pacific Garbage Patch should search for long-living TRAPs that are at an advanced stage of their life cycle. These TRAPs are the most likely to induce a large-scale confluence of drifting objects and their streamlining into hyperbolic pathways. Such a streamlined bypass takes, on average, 5 d and creates an opportunity to filter the flow around TRAPs. But we also find TRAPs that retain material over multiple weeks where we suspect material clustering at the submesoscale. Prospective research could investigate this further by applying our algorithms to soon-available high-resolution observations of the flow. Our analysis contributes to a better understanding of TRAPs, which can even benefit other offshore operations besides ocean cleanups, such as optimal drifter deployment, oil spill containment, and humanitarian search and rescue.
PENGEMBANGAN E-MODUL KERAGAMAN BUDAYA INDONESIA BERBASIS TPACK TERINTEGRASI TRI N UNTUK MENINGKATKAN DIMENSI KREATIF SISWA
Authors: Sakti Dewanti Novita , Maria Zulfiati Heri , Wibawa Sutrisna
Published: December 2024

Penelitian pengembangan ini dilakukan berdasarkan hasil observasi dan wawancara yang dilakukan pada salah satu sekolah dasar di Kabupaten Sleman. Diketahui siswa kelas IV belum memahami berbagai macam keanekaragaman budaya yang ada di Indonesia, karena Indonesia mempunyai banyak sekali keanekaragaman budaya. Hal ini terjadi karena bahan ajar yang digunakan guru masih terbatas. Guru hanya fokus pada bahan ajar cetak, sehingga pembelajaran pun terkesan sedikit monoton atau hanya terbatas pada buku. Tujuan penelitian ini adalah menghasilkan bahan ajar praktis e-modul keragaman budaya Indonesia  berbasis TPACK Terintegrasi Tri N untuk meningkatkan dimensi kreatif siswa.  Model pengembangan yang digunakan adalah ADDIE yang terdiri dari lima tahap yaitu (1) Analisis, (2) Desain, (3) Pengembangan, (4) Implementasi dan (5) Evaluasi. Melalui tahap validasi media, materi dan bahasa diperoleh hasil sebesar 82,17% sehingga modul baru layak digunakan. sedangkan respon siswa sebesar 86,5% Keterterimaan pada tataran praktis dan dapat digunakan siswa dalam pembelajaran IPS maupun Pendidikan Pancasila yang didalamnya terdapat materi tentang keragaman budaya Indonesia.
Impacto do investimento estrangeiro no crescimento económico em Moçambique (2000-2020)
Authors: Sousa Yazalde Viana Serafina de , Nhabinde Simeão
Published: December 2024

O objectivo deste artigo é analisar detalhadamente o impacto do IDE no crescimento económico de Moçambique no período de 2000 a 2020, explorando tanto os aspectos positivos quanto as limitações desse investimento no contexto local. Durante essas duas décadas, Moçambique testemunhou uma transformação económica significativa, impulsionada principalmente pelos fluxos crescentes de IDE em sectores estratégicos, como a exploração de recursos naturais. Utilizando uma análise econométrica detalhada de dados de instituições como o Banco de Moçambique, FMI e UNCTAD, este estudo busca avaliar a contribuição do IDE para o crescimento do Produto Interno Bruto (PIB) do país. Os resultados indicam que, embora o IDE tenha impulsionado o crescimento económico, sua concentração em megaprojectos de capital intensivo e voltados para exportação limitou o impacto positivo sobre a criação de empregos e a melhoria das condições de vida. O estudo também discute a necessidade de diversificação económica, fortalecimento institucional e reformas que facilitem a maximização dos benefícios económicos do IDE para Moçambique.
Diversidad, alteridad y empatía en The Last of Us Part II. Análisis textual del videojuego desde la óptica feminista
Authors: Arrieta Castillo Carolina
Published: December 2024

Introducción. The Last of Us: Part II es un videojuego de aventura, acción y terror aclamado por la crítica pero rechazado por gran parte del público debido fundamentalmente a la lectura en clave feminista que la comunidad gamer hizo del juego. Objetivos. En el estudio se pretende comprobar hasta qué punto rompe con la estereotipia sexista un videojuego de gran producción cuyo público potencial es mayoritariamente masculino. Asimismo, se trata de aportar un marco metodológico que tenga en cuenta los distintos planos del videojuego desde una perspectiva feminista. Metodología. Con este propósito se lleva a cabo un análisis de tipo cualitativo desde un enfoque de la teoría feminista a los planos narrativo, ludológico y enunciativo para relacionar las dimensiones formal y social de la obra Resultados. El análisis revela que a través de la representación de personajes femeninos diversos y el desarrollo de estrategias ludonarrativas que permiten experimentar la alteridad y la empatía en un universo caracterizado por la violencia, The Last of Us: Part II se erige en un producto cultural de interés para las prácticas de empoderamiento femenino posibilitando la construcción de imaginarios sociales más igualitarios; especialmente dentro de un sector, como es el triple A del videojuego, fuertemente masculinizado. Discusión y Conclusiones. La industria del videojuego ha sido un sector tradicionalmente masculino en el que las mujeres han sido concebidas conforme a estereotipos perniciosos. Para combatirlos, este estudio contribuye a reclamar el papel del videojuego como discurso capaz de fomentar procesos de reflexión valiosos respecto a temas de interés feminista.
INDUSTRY 4.0. VS. 5.0.: SYNTHESIS AND EVOLUTION OF THE CONNECTED INDUSTRY
Authors: Intxaurbe Iriondo Jatsu , ALBIZU GALLESTEGI ENEKA
Published: December 2024

This paper reviews the concept of Industry 4.0, a production paradigm that is becoming increasingly important in the manufacturing industry. Its main objective is to clarify this concept and establish the existing relations with the recently coined Industry 5.0. Initially, Industry 4.0 arose as a result of various governmental policies. Its materialization is understood through the integration of its enabling technologies, aimed at improving productivity and flexibility in industrial processes. This paper emphasizes the importance of understanding Industry 4.0 through the synergies generated between its technologies. In contrast to the efficiency focus of Industry 4.0, the Industry 5.0 paradigm emerged in 2021 as a European proposal aimed at creating a people-centered, resilient, and sustainable industry. It reflects on the enduring technologies from the 4.0 approach and those incorporated specifically to achieve renewed social and environmental goals. The paper concludes by differentiating between the two paradigms based on the Sustainable Development Goals (SDGs).
Konusu Taşınmaz Olan Ortaklığın Giderilmesi Uyuşmazlıklarına İlişkin Arabuluculukta İcra Edilebilirlik Şerhi Üzerine Düşünceler
Authors: Tiyek Fikret Sami , Zengin Hüseyin Kağan , Topal Önder
Published: December 2024

6325 sayılı Hukuk Uyuşmazlıklarında Arabuluculuk Kanunu (HUAK) ile birlikte dostane uyuşmazlık çözüm yöntemlerinden birisi olan arabuluculuk, yasal çerçevede hayatımıza girmiştir. Esasında ihtiyarî arabuluculuğa ilişkin hükümleri düzenleyen HUAK’a sonradan yapılan eklemelerle birlikte, belirli uyuşmazlık türleri için dava açılmasından önce arabulucuya başvuru zorunlu hale gelmiştir. Tarafların, arabulucu nezdinde bir araya gelip uyuşmazlıklarını kendilerinin çözmelerinin öngörüldüğü süreçte, zaman içinde hem uyuşmazlık türleri genişletilmiş hem de arabulucuya çözüm önerisi getirme imkânı tanınmıştır.
Gittikçe genişleme eğilimi gösteren dava şartı arabuluculuk uygulaması kapsamına, HUAK m.18/B ile taşınır ve taşınmazların paylaştırılmasına ve ortaklığın giderilmesine ilişkin uyuşmazlıklar dâhil edilmiştir. Özellikle taşınmazlar bakımından, kanunlarımızda yer alan çeşitli kısıtlayıcı hükümler çerçevesinde, dava şartı arabuluculuk uygulamasının tüm yönleriyle irdelenmesi gerekmektedir.
Bu çalışmada, ortaklığın giderilmesi uyuşmazlıklarının arabuluculuğa ne ölçüde elverişli olduğu ve özellikle arabuluculuk süreci sonunda taraflarca hazırlanacak anlaşma belgesinin hüküm ve sonuçları incelenmiştir. Nitekim kanun koyucu, tarafların anlaşması halinde hazırlanacak anlaşma belgesinin, taşınmazlar bakımından özel hükümlere uyularak hazırlanması gerektiğine işaret etmiştir. Buna ek olarak, anlaşma belgesinin icra edilebilmesi için sulh hukuk mahkemesinden icra edilebilirlik şerhinin alınması şart koşulmuştur. Çalışmamızda, tüm güncel gelişmeler gözetilerek, anlaşma belgesinin ne şekilde icra edilebileceği, bu sebeple alınması öngörülen icra edilebilirlik şerhi ile ilgili açıklamalar ve değerlendirmeler yapılmıştır. Ayrıca, anlaşma belgesiyle birlikte resmî daire ve kurumlarda yapılabilecek işlemler, icra edilebilirlik şerhi alınması süreciyle birlikte değerlendirilip uygulamada yaşanan sorunlara somut çözüm önerileri getirilmiştir.
Anonim Ortaklığın Çağrı Usulüne Uyulmadan Yapılan Genel Kurul Toplantısı İçin Bakanlık Temsilcisinin Görevlendirilmesi Talebi
Authors: Akbaş İsmail
Published: December 2024

Anonim ortaklığın temel organlarından biri genel kuruldur. Genel kurul esasen pay sahiplerinin toplanması ile meydana gelir. Genel kurulda alınan kararlar anonim ortaklığın iradesini oluşturur. Bu önemi dolayısıyla genel kurul çeşitli prosedürlere göre çağrılır, toplanır ve karar alır. Bu prosedürler bir yandan ortaklığın, diğer yandan pay sahiplerinin menfaatine hizmet eder.
Bazı genel kurul toplantılarında Ticaret Bakanlığı temsilcisinin bulunması kanun koyucu tarafından şart tutulmuştur. Bu temsilcinin atanmasına dair ayrıntılı hükümler yönetmelik ile düzenlenmiştir. Ancak yönetmelik uygulamada sorun çıkarabilecek hükümler içermektedir.
İşbu çalışmada genel kurulun çağrı usulüne uyulmaksızın toplanması durumunda Bakanlık temsilcisinin atanmasına yönelik özel durumlar yönetmelik hükümleri çerçevesinde ele alınacaktır.
Motivational Antecedents in Call Center Industry
Authors: Saeed Hamid , Rajan Thanachelvan a/I , Butar-Butar Herry Fernades , Sameem MAM
Published: December 2024

To make the employees perform their task in the most efficient manner has always been tough for the management. To achieve this goal, management is required to have proper understanding of various factors that encourage motivation in employees. Since the last decade, there is rapid increase in a trend of call center industry in Pakistan. Nowadays, numerous foreigner businesses have outsourced their customer services and tele sales in developing countries like Pakistan. This study is intended to highlight all those factors that play an important role for encouraging motivation level of employees in Call Center Industry of Lahore. This research discusses the effect of Autonomy, Justice, Rewards and Recognition and Training on Employees motivation in the selected industry. To conduct the study, primary data is collected, and statistical tests are applied to measure the relationship between our supposed dependent and independent variables.
Makanan Khas Bali Di Desa Wisata Bakas Berpotensi Besar Dikembangkan Menjadi Wisata Gastronomi
Authors: Sutiarso Moh Agus , I Nyoman Arto Suprapto  , Ni Ketut Alit Sujarmini
Published: December 2024

Bakas Village is one of the tourist villages in Klungkung Regency, Bali, which has begun to offer gastronomic tourism attractions based on traditions that are still maintained by the local community, namely the tradition of cooking traditional Balinese cuisine. This study was conducted to produce a study that explains how Balinese cuisine can become gastronomic tourism in Bakas Tourism Village. This study was conducted using a primary survey method, namely field observation and interviews with key informants from Bakas Tourism Village. Data collection was supported by a checklist instrument consisting of 7 variables with 28 indicators based on qualitative descriptions from the Guidelines for the Development of Gastronomy Tourism book published by the United Nation World Tourism Organization (UNWTO). It was filled in using the Likert scale method with a score range of 1-5. Furthermore, the results of this checklist were described using quantitative and qualitative descriptive analysis methods. Based on observations and data processing, it was found that Bakas Tourism Village has great potential in developing gastronomic tourism. It's just that there are still several sectors that need to be fixed or developed again by Bakas Tourism Village in order to improve gastronomy in this village.
Biochemical and Histological Improvements in Alloxan-Intoxicated Diabetic Rats via Administration of Vitex agnus-cactus Seed Extract
Authors: El Kamari Fatima , Ousaaid Driss , Laaroussi Hassan , Bouchyoua Abdelaghani , Chlouchi Amina , Harmouzi Anjoud , El Hamzaoui Najia , El Amrani Jihane , Lyoussi Badiaa
Published: December 2024

Natural resources constitute an exhaustible source of bioactive compounds well-known for their antidiabetic properties. This study investigated the antioxidant and antidiabetic activities of Vitex agnus citratus extract against alloxan-induced metabolic disorders in an animal model. The antioxidant ability of the extract was evaluated using three complementary assays (TAC, DPPH, and FRAP), and its total phenolic and flavonoid contents were determined calorimetrically. The in vivo experiment included five groups: group 1 received distilled water (10ml), group 2 received alloxan (150 mg/kg) and distilled water (10ml), group 3 received alloxan (150 mg/kg) and V. agnus cactus aqueous extract (200mg/kg bw), group 4 received alloxan (150 mg/kg) and VAC aqueous extract (300mg/kg bw), and group 5 received alloxan (150 mg/kg) and glibenclamide. The doses were administered once daily via gavage for four weeks. Blood glucose levels, hepatic enzymes, uric acid, urea, creatinine, and electrolytes were analyzed after four weeks of treatment. The antioxidant profile of VAC extract revealed considerable phenolic and flavonoid contents and an impressive antioxidant ability (37.6 ± 0 .73 mg EAA/g, 0.54±0.46 mg/mL, and 0.7±0.03 mg/mL for TAC, DPPH-IC50, and FRAP, respectively). Treatment of rats with V. agnus cactus extract significantly improved all changes induced by alloxan injection by controlling hyperglycemia, liver and kidney disorders, and serum electrolyte levels. Therefore, using V. agnus cactus would have pleiotropic effects in preventing metabolic disorders induced by alloxan.
Anti-Epileptic Indian Medicinal Plants: A Comprehensive Review on their Ethnopharmacological Perspectives of Recent Advancement
Authors: Sinoriya Pooja , . Gaurav
Published: December 2024

The study explores the potential of Indian medicinal plants as botanical treasures for managing epilepsy. Epilepsy, a neurological disorder characterized by recurrent seizures, poses a significant global health challenge. Traditional medicinal practices in India have a rich history of incorporating various plant-based remedies for neurological ailments, including epilepsy. The data was collected from various scientific databases like Google Scholar, Science Direct, Elsevier, Springer and Pubmed. The collected data includes the following details - Plant part used, dose and type of extract, reference and inducing drug used and the mechanism of actions. The article thoroughly examines the phytochemical constituents found in Indian medicinal plants, elucidating their neuroprotective and anticonvulsant properties and their scrutinized bioactive compounds and therapeutic potential. The review integrates findings from preclinical and clinical studies, shedding light on the mechanisms of action and safety profiles of these plant-derived compounds. The conclusion of the manuscript emphasizes the promising role of Indian medicinal plants in epilepsy management. The identified botanical treasures offer a holistic and potentially sustainable approach to complement existing antiepileptic medications. The reviewed evidence underscores the need for further research, clinical trials, and integration of traditional knowledge into mainstream healthcare for the development of effective and accessible treatments for epilepsy. By recognizing the botanical wealth embedded in Indian traditional medicine, this review advocates for a paradigm shift toward harnessing nature's gifts in the pursuit of enhanced epilepsy care.
Effects of Different Doses of Probiotic Supplementation to Diet on Performance, Organ Weight and Some Blood Parameters in Broilers
Authors: Zengin Muhittin , Eseceli Hüseyin , Kalaydzhiev Georgi , Sur Aslıhan , Demir Ergün , Azman Mehmet Ali
Published: December 2024

Probiotics are live microorganisms such as bacteria, fungi, or yeast that supports the gastrointestinal flora and promote growth performance when administered in sufficient amounts. The current study was conducted to examine the impact of different doses of probiotic mix (Lactobacillus delbrueckii subsp. bulgaricus, Streptococcus thermophiles, Lactobacillus acidophilus, Lactococcus lactis, Propionibacterium) on performance, organ weights, and some blood parameters in broilers. For this aim, a total of 360 two-day-old Ross-308 mixed-sex broiler chickens were randomly divided into 5 groups with 6 replicates containing 12 chicks per replicate. All of them were fed with 5 different dietary intakes for 40 days as follows: Control (Con; basal diet), Trial I (TI; 0.05% adding probiotics), TII (0.075% adding probiotics), TIII (0.10% adding probiotics), and TIV (0.125% adding probiotics). After the treatments, performance parameters and organ weights were evaluated. Also, blood specimens were collected for sero biochemical analysis. Data showed that the highest body weight (BW), average daily weight gain (ADWG), and feed conversion rate (FCR) were determined in the TII group (P
Analisis Strategi Komunikasi Politik Ridwan Kamil di Media Sosial Instagram dalam Membangun Citra Diri Menuju PILGUB DKI Jakarta 2024
Authors: Ahmad Naila , Pohan Khalifa , Alfira Salwa , Aufia Kanina , Paripurna Clarissa , Aji Muhammad
Published: December 2024

Penelitian ini menganalisis strategi komunikasi politik Ridwan Kamil di media sosial Instagram dalam membangun citra dirinya menjelang Pilgub DKI Jakarta 2024. Dengan meningkatnya penggunaan media sosial sebagai alat kampanye politik, Instagram menjadi salah satu platform penting bagi politisi untuk menyampaikan pesan dan berinteraksi dengan pemilih. Ridwan Kamil memanfaatkan fitur visual dan interaktif Instagram untuk menjangkau audiens, terutama generasi muda, dengan konten yang menarik dan relevan. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif analitis, mengumpulkan data dari studi pustaka, dan analisis konten media sosial Instagram. Hasilnya menunjukkan bahwa Ridwan Kamil memanfaatkan strategi komunikasi yang meliputi interaksi dua arah, penggunaan konten visual yang menarik, serta responsif terhadap isu-isu lokal. Melalui unggahan yang menampilkan kedekatannya dengan masyarakat, ia berhasil menciptakan citra positif sebagai calon pemimpin yang inovatif dan peduli. Namun, tantangan seperti penyebaran berita hoaks menjadi faktor penting yang harus diatasi. Temuan ini diharapkan dapat memberikan wawasan bagi kandidat lain dalam memanfaatkan media sosial Instagram, untuk membangun citra diri dan meningkatkan interaksi dengan pemilih dalam konteks politik kontemporer.
New Horizons in Health and Metabolism Research
Authors: Lin Donghai , Hu Shen , Huang Peng , Wan Jianbo , Wang Yulan
Published: December 2024

Editorial
New Horizons in Health and Metabolism Research

Donghai Lin 1, *, Shen Hu 2, Peng Huang 3, Jianbo Wan 4 and Yulan Wang 5

1 Department of Chemical Biology, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen, China.
2 School of Dentistry, University of Capfornia, Los Angeles, CA, USA; shenhu@ucla.edu.
3 State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; huangpeng@sysucc.org.cn
4 State Key Laboratory of Quapty Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China; jbwan@um.edu.mo.
5 Lee Kong Chian School of Medicine,Nanyang Technological University, Singapore; wang@ntu.edu.sg.
* Correspondence: dhlin@xmu.edu.cn;

Received: 30 September 2024; Accepted: 8 October 2024; Published: 16 October 2024
A Simple Phthalocyanine-Peptide Conjugate as Targeting Photosensitizer and Its Broad Applications in Health
Authors: Chen Zheng , Chen Jincan , Liu Dafeng , Chen Jingyi , Li Linlin , Chen Dan , Chen Naisheng , Huang Jinling , Chen Zhuo , Xu Peng , Jiang Longguang , Yuan Cai , Jiang Yunbin , Huang Mingdong
Published: December 2024

Review
A Simple Phthalocyanine-Peptide Conjugate as Targeting Photosensitizer and Its Broad Applications in Health

Zheng Chen 1, Jincan Chen 2, Dafeng Liu 3, Jingyi Chen 1, Linlin Li 1, Dan Chen 1, Naisheng Chen 1, Jinling Huang 1, Zhuo Chen 2, Peng Xu 4, Longguang Jiang 1, Cai Yuan 4,*, Yunbin Jiang 5,* and Mingdong Huang 1,*

1 National & Local Joint Biomedical Engineering Research Center on Photodynamic Technologies, College of Chemistry, Fuzhou University, Fuzhou 350108, China
2 State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fujian College, University of Chinese Academy of Sciences, Fuzhou 350002, China
3 College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China
4 College of Biological Science and Engineering, Fuzhou University, Fuzhou 350108, China
5 School of Biological Science and Biotechnology, Minnan Normal University, Zhangzhou 363000, China
* Correspondence: cyuan@fzu.edu.cn (C.Y.); jyb1972@mnnu.edu.cn (Y.J.); HMD_lab@fzu.edu.cn (M.H.)

Received: 28 August 2024; Revised: 9 October 2024; Accepted: 17 October 2024; Published: 25 October 2024

Abstract: Photodynamic therapy is a novel clinical treatment for malignant tumors, and has recently been extended to anti-bacteria and anti-virus applications. Phthalocyanine photosensitizers possess good photosensitization properties, but their high hydrophobicity and lack of targeting capabilities limit their application. By conjugating a pentalysine peptidyl moiety to hydrophobic phthalocyanine, a novel photosensitizer (ZnPc(Lys)5) was synthesized. This review systematically summarizes the design, development, safety and characterization of ZnPc(Lys)5, and describes its applications and mechanisms in anti-tumor, anti-bacterial and anti-viral areas, as well as exploring its prospects for applications beyond photodynamic therapy. This review demonstrates that the peptide conjugation is an effective strategy for enhancing water solubility and broadens the applications of phthalocyanine-type photosensitizers. Furthermore, the importance of dynamic balance between the monomeric and aggregate conformations of phthalocyanine underlying its photodynamic effect is highlighted, providing a fresh perspective for the design and application of photosensitizers.
Endoplasmic Reticulum Unfolded Protein Responses: Molecular Mechanism and Role in Pathophysiology
Authors: Wu Miankun , Feng Fen , Cao Jiangang , Chen Linxi
Published: December 2024

Review
Endoplasmic Reticulum Unfolded Protein Responses: Molecular Mechanism and Role in Pathophysiology

Miankun Wu 1,†, Fen Feng 2,†, Jiangang Cao 3,* and Linxi Chen 1,*

1 Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, School of Pharmaceutical Science, Hengyang Medical College, University of South China, Hengyang 421001, China
2 The School of Pharmacy, Shaoyang University, Shaoyang 422000, China
3 The Affiliated Nanhua Hospital, Clinical Pharmacy Research Institute, Hengyang Medical School, University of South China, Hengyang 421001, China
* Correspondence: jgcao66@whu.edu.cn (J.C.); 1995001765@usc.edu.cn (L.C.)
† These authors contributed equally to this work.

Received: 29 July 2024; Revised: 29 September 2024; Accepted: 15 October 2024; Published: 30 October 2024

Abstract: To alleviate ER stress, Endoplasmic reticulum unfolded protein responses (ER UPR) is a set of defensive mechanisms that induce the nucleus to decrease protein synthesis due to incorrect protein aggregation in the ER triggered by different pathogenic causes. Overactivation of ER UPR has been linked to a multitude of human disorders, such as autoimmune diseases, malignancies, hypertension, and retinopathy, according to an increasing number of studies. In addition, ER UPR activity prolongs cell life and delays the aging process by preserving the equilibrium of proteins in the endoplasmic reticulum lumen. Furthermore, as described in the literature recently, adaptive activation of ER UPR improves hypertension, obesity, cardiovascular disease, and neurodegenerative illnesses. Targeting ER UPR pathways may be a useful therapeutic approach for treating diabetes, obesity, fatty liver, and neurodegenerative illnesses given the diversity of ER UPR.
Evaluation of nutritional status and salivary markers of cardiometabolic risk in schoolchildren
Authors: Moura Veronica Rangel de , Lopes Carlos Eduardo Vaz , Reis Raman Alves dos , Cunha Gabriel Boaventura da , Nunes Rodolfo de Alkmim Moreira , Kallembach Anna , Bentes Cláudio Melibeu , Lisboa Patrícia Cristina , Lopes Gustavo Casimiro
Published: December 2024

Obesity is caracterized as an excessive accumulation of body fat that can adversely affect individual health. In this study, we recruited 69 schoolchildren (33 boys and 36 girls; age: 11.5±2.5) from different school locations, that were classified according to body mass for age in: underweight (UW), eutrophic (E) or overweight/obese (Ow/Ob). We assessed anthropometry parameters, physical fitness tests, and conducted biochemical analysis of some salivary markers. Our analysis revealed that girls had higher body weight and subcutaneous fat, but with lower levels of muscular and aerobic endurance, compared to boys (p<0.05). Interestingly, obese boys demonstrated a decline in aerobic fitness capacity during a walk-run test relative to their eutrophic peers. This decline in aerobic capacity was also positively associated with elevated triglyceride levels in saliva. Salivary uric acid were positively associated with physical fitness. The lower levels of this parameter in Ow/Ob group could be due to loss of antioxidant status induced by this condition. In conclusion, this study highlights the relevant effect of physical activity on body composition and biochemical markers. It suggests that chronic exercise among schoolchildren could be a relevant strategy to mitigate the metabolic and redox imbalances associated with overweight and obesity.
Tecnologias digitais e educação: reflexões sobre a saúde emocional dos estudantes no contexto do ensino remoto
Authors: Uchôa Ana Lúcia Muniz Baptista , Alves Maria Regina Menezes , Monteiro Patrícia Ortiz
Published: December 2024

Este artigo é um recorte de uma pesquisa mais ampla que examina os impactos da pandemia de COVID-19 no sistema educacional brasileiro. A pesquisa, conduzida pela autora com foco nas Tecnologias Digitais da Informação e Comunicação (TDIC) no Ensino Remoto Emergencial (ERE), analisa também a saúde emocional dos alunos. A pandemia forçou professores e alunos a se adaptarem rapidamente ao ensino à distância, destacando a necessidade de entender como as TDIC foram utilizadas para garantir a continuidade educacional em tempos de crise. Embora muitos alunos já tivessem alguma familiaridade com as TDIC, a transição para seu uso diário e disciplinado apresentou desafios significativos. O estudo buscou analisar a saúde emocional dos alunos durante o ensino remoto emergencial. A metodologia incluiu desenhos (iconografia) e questionários. Os resultados mostraram que os alunos enfrentaram dificuldades de adaptação, mas conseguiram continuar seus estudos, ainda que de forma secundária. A pesquisa destaca a importância de compreender o processo de ensino-aprendizagem e contribuir para práticas pedagógicas mais eficazes, levando em consideração as narrativas dos alunos, fatores essenciais para a continuidade da educação no cenário pós-pandemia.
Politica delle traduzioni e metodi della traduzione giuridica nel periodo napoleonico
Authors: Schreiber Michael
Published: December 2024

Il presente contributo tratta gli aspetti seguenti: La politica delle traduzioni durante la Rivoluzione francese e il periodo napoleonico in Francia, Belgio, Italia e Germania; i profili tipici di traduttori giuridici in questo periodo; i metodi della traduzione giuridica (letterale/straniante vs. libera/naturalizzante). I dati provengono da progetti di ricerca finanziati dalla Deutsche Forschungsgemeinschaft. Secondo l’autore di questo studio, la politica delle traduzioni non è una fase effimera della Rivoluzione francese, ma riguarda l’intera epoca fino alla fine del periodo napoleonico. Il metodo di traduzione predominante è la traduzione (più o meno) letterale, con solo alcuni adattamenti alla lingua e cultura d’arrivo.
Enhancing Decision-Making in Uncertain Environments: The Role of Neutrosophic Cognitive Maps in Analyzing Complex Systems
Authors:   Regional Autonomy University of Los Andes (UNIANDES), Ecuador, Jose Jose ,   Regional Autonomy University of Los Andes (UNIANDES), Ecuador,   Regional Autonomy University of Los Andes (UNIANDES), Ecuador,   Brigham Young University–Idaho, USA,   Research and Innovations Department, Tashkent State University of Economics, Uzbekistan, Pijal Sheila Belen Esparza , Verdezoto Mónica Isabel Mora , Cevallos-Torres Lorenzo Cevallos , Mirzaliev Sanjar
Published: December 2024

Using Neutrosophic Cognitive Maps (NCM), this research tackles the very core of one of the main problems that exist in the analysis of complex structures and systems: how to represent and model decision making in situations of uncertainty, or where there is contradiction and ambiguity. This problem gets even worse in the areas of knowledge management, strategic evaluation, or design of public policies since orthodox methods do not always possess required versatility for combining partially available or contradicting information. To address this challenge, the researchers recommend Neutrosophic Cognitive Maps (NCM) as a more appropriate technique considering that the neutrosophic logic can depict and study more intricate relationships in the presence of indeterminacy. There is an iterative learning of cognitive maps which is coupled with neutrosophic analysis techniques enabling the construction of a comprehensive model capturing both certainties and the undefined and disputed areas of the evaluated systems. The findings obtained in this research demonstrate how effective NCMs are in the spatial and analytic representation of complex and multifactorial situations providing features that go beyond the conventional structure models. Apart from broadening theorization on decision-making processes in an uncertain situation, this research provides practical tools applicable in sectors such as strategic planning, complex problem solving and organizational management. In short, the study shows that neutrosophic, used as a methodological catalyst, not only expands the possibilities of analysis but also transforms how complex systems are conceptualized and managed in the academic and practical fields.
The role of TGF- receptor mutations in epithelial-mesenchymal transition and metastasis in lung cancer
Authors: Huang Bohan
Published: December 2024

Lung cancer is one of the leading causes of cancer mortality around the world. The progression of lung cancer is often marked by the metastasis, which is a progress where the lung cancer cells start to spread out to other organs and systems in our human body. This progression is always marked by the scientists as the sign of the mortality of the patient. Epithelial-mesenchymal transition (EMT) is a critical process in the development of lung cancer, contributing to metastasis and resistance to therapy. EMT facilitates the invasion of the cancer cell, and prevents the apoptosis. EMT also enhances tumor cell survival, and resistance to the conventional chemotherapy or target treatment. It is an important process that leads to the spread of cancer cell and cause death. This essay focuses on the molecule transforming growth factor-beta (TGF-), which plays a central role in regulating EMT. In particular, mutations in TGF- receptors significantly impact this process. This essay examines the effects of TGF- receptor mutations on EMT in lung cancer, analyzing common and emerging mutations, their functional consequences, and the potential therapeutic implications. By exploring the altered signaling pathways and their effects on EMT markers, this study provides insights into the role of TGF- receptor mutations in lung cancer metastasis and prognosis.
Exploring the antitumor mechanisms of quercetin and kaempferol from Traditional Chinese Medicine against lung cancer through network pharmacology and molecular docking
Authors: Song Haibing , Li Guangzhen
Published: December 2024

Although the two compounds quercetin and kaempferol components of TCM were verified as useful anticancer compounds, their molecular mechanisms are not well discussed. The present work aims to demystify the antitumor mechanisms of TCM compounds. Therefore, network pharmacology and pharmacophore screening were adopted with molecular docking to identify the bioactive compounds possessing excellent oral bioavailability and drug-likeness. The method of pharmacophore screening was then employed to examine molecular interactions occurred between the compounds and targets. The gene-disease associations were collected from the DisGeNET database. The STRING database was utilized to cluster overlapping targets. The key targets were identified, and molecular docking with quercetin and kaempferol was performed against these targets to further characterize drug binding affinities, which verified strong binding affinities comparable with the known anticancer drugs. The multitarget inhibitor was identified and exerted a powerful inhibitory effect on tumor cells, as demonstrated by the CCK-8 assay. Quercetin and kaempferol components derived from TCM with good oral bioavailability and drug-likeness held promise for effective antitumor treatment, especially for tumors resistant to other treatment.
Epigenetic regulation of skeletal muscle satellite cells in exercise-induced injury repair
Authors: Hu Qinyuan
Published: December 2024

Individuals, ranging from the average person to athletes, face potential risks of exercise-related injuries. To explore the mechanisms of repair, it is imperative to focus on skeletal muscle, whose regeneration depends on a resident population of muscle stem cells known as satellite cells. Through meticulous experimentation and research, it has been revealed that epigenetic regulatory mechanisms, such as DNA methylation, histone modifications, and non-coding RNAs, play a pivotal role in governing gene expression within skeletal muscle satellite cells. These findings underscore the significant impact of these regulatory processes in addressing exercise-induced injuries.
O ensino de Geografia pela perspectiva de alunos da rede básica de ensino
Authors: Souza Silva Maria Liziane , Barros Pereira Paulo Cesar
Published: December 2024

O espaço geográfico caminha em constante transformação e nos últimos tempos encontra-se mergulhado em um complexo globalizado e dinâmico imbróglio, exigindo maior compreensão de suas relações sociogeográficas. A disciplina de Geografia entra como ferramenta importante, tanto para analisar essa dinâmica, como para desenvolver no sujeito seu senso crítico e reflexivo. Ao meditar sobre sua realidade ele também poderá identificar as dicotomias deste processo fazendo relação entre o local e o global. O objetivo deste artigo foi identificar o interesse de alunos da rede básica de ensino de Rio Branco Acre pela ciência geográfica. Como método, adotamos a Dialética para análise da realidade escolar e seu contexto social. Quanto a técnica foi aplicada um questionário em sala de aula e realizado uma pesquisa documental. Esta pesquisa revelou boa disposição e interesse dos alunos pela ciência geográfica; não possuem grandes problemas quanto ao seu aprendizado e gostam da forma como os professores abordam os conteúdos.
Editorial - v. 9 n. 1 (2023)
Authors: Fraga Nilson Cesar , Martins da Silva Matheus Oliveira
Published: December 2024

Editorial
Shoulder Arthroplasty Patients Are Underscreened for Osteoporosis
Authors: Malyavko Alisa , Agarwal Amil R. , Mikula Jacob D. , Best Matthew J. , Srikumaran Uma
Published: December 2024

Introduction:

Osteoporosis screening and subsequent treatment has been shown to be efficacious in decreasing the rates of fragility fractures and periprosthetic fractures (PPF). However, current screening and treatment rates are low. This study aims to determine (1) the prevalence of total shoulder arthroplasty (TSA) patients who meet criteria for osteoporosis screening, (2) the prevalence of those screened, and (3) the 5-year cumulative incidence of fragility fracture (FF) and periprosthetic fractures (PPF).

Methods:

The PearlDiver database was used to identify all patients older than 50 years who underwent TSA. Guidelines from the American Association of Clinical Endocrinologists were used to stratify patients into “high risk” and “low risk” of osteoporosis cohorts using International Classification of Disease codes for various risk factors. The prevalence of osteoporosis screening using dual-energy x-ray absorptiometry (DXA) scan was analyzed, and the 5-year cumulative incidence of FF and PPF was calculated between the “low-risk” and “high-risk” groups using Kaplan-Meier analysis.

Results:

In total, 66,140 (65.5%) who underwent TSA were considered “high risk” for osteoporosis. Of the “high-risk” patients, 11.7% patients received routine osteoporosis screening preoperatively. Within 5 years, “high-risk” TSA patients had markedly higher cumulative incidence for PPF (HR: 1.4; 95% CI: 1.0-1.9; P = 0.037) and FF (HR: 2.42; 95% CI: 2.1-2.8; P < 0.001) when compared with those at “low risk”.

Discussion:

There is a high prevalence of osteoporosis among patients undergoing TSA but a low rate of routine osteoporosis screening in this cohort. Patients with osteoporosis who are categorized as “high risk” have an increased rate of fragility fractures and PPF. Therefore, there is an opportunity to increase appropriate osteoporosis screening and management in this cohort, which may affect future risk of FF and periprosthetic fracture.

Level of evidence:

III
Inovasi Pembelajaran untuk Generasi Bermoral
Authors: Kusumawati Tri Indah , Pulungan Enny Nazrah , Wati Amilia Sanggar
Published: December 2024

Penelitian ini dilatarbelakangi oleh fenomena yang terjadi di UIN SU sebagian mahasiswa kehilangan arah dan kurang memiliki moral. Inovasi pembelajaran yang dibuat dosen membuat kesadaran diri bagi mahasiswa pentingnya memiliki moral yang baik. Penelitian ini bertujuan untuk menganalisis seperti apa inovasi pembelajaran membuat mahasiswa memiliki moral. Jenis penelitian ini adalah deskriptif kualitatif, subjek penelitian yaitu satu orang dosen UIN SU Tadris Bahasa Indonesia. Pengumpulan data dilakukan dengan observasi, wawancara dan dokumentasi. Analisis data menggunakan pendekatan deskriptif kualitatif. Hasil penelitian ini menunjukkan inovasi pembelajaran untuk membuat generasi menjadi bermoral membuat mahasiswa memahami pentingnya memiliki moral yang baik. Dosen memberikan pendekatan yang menyeluruh dan integratif dalam pengajarannya, dan menutup perkuliahan dengan memberikan perumpamaan. Dosen memainkan peran penting dalam membentuk karakter mahasiswa, serta mengajarkan nilai-nilai moral melalui berbagai metode pembelajaran melalui diskusi. Penelitian ini dapat menjadi acuan bagi institusi pendidikan untuk melakukan inovasi dalam pembelajaran membuat generasi yang tidak hanya cerdas tetapi juga bermoral.