bluuebunny/crossref_metadata_2025 huggingface dataset:
Study of adsorption mechanism of Congo Red on graphene oxide/PAMAM nanocomposite
Authors: Rafi Mohammad , Samiey Babak , Cheng Chil-Hung
Published: July 2021

Graphene oxide/poly(amidoamine) (GO/PAMAM) nanocomposite adsorbed high quantities of congo red (CR) anionic dye in 0.1 M NaCl solution, with the maximum adsorption capacity of 198 mg·g−1. The kinetics and thermodynamics of adsorption were investigated to elucidate the effects of pH, temperature, shaking rate, ionic strength, and contact time. Kinetic data were analyzed by the KASRA model and the KASRA, ISO, and pore-diffusion equations. Adsorption adsorption isotherms were studied by the ARIAN model and the Henry, Langmuir, and Temkin equations. It was shown that adsorption sites of GO/PAMAM at experimental conditions were phenolic hydroxyl groups of GO sheets and terminal amine groups of PAMAM dendrimer. Analysis of kinetic data indicated that amine sites were located on the surface, and that hydroxyl sites were placed in the pores of adsorbent. CR molecules interacted with the adsorption sites via hydrogen bonds. The molecules were adsorbed firstly on the amine sites, and then on the internal hydroxyl sites. Adsorption kinetic parameters indicated that the interaction of CR to the –NH3+ sites was the rate-controlling step of adsorption of CR on this site and adsorption activation energies calculated for different parts of this step. On the other hand, kinetic parameters showed that the intraparticle diffusion was the rate-controlling step during the interaction of CR molecules to –OH sites and activation energy of this step was not calculable. Finally, the used GO/PAMAM was completely regenerated by using ethylenediamine.
Synthesis of Fibrous Nanoparticle Aggregates by Femtosecond Laser Ablation in Air
Authors: Tan Bo , Venkatakrishnan Krishnan
Published: July 2021

In this article we report the synthesis of nanoparticles using femtosecond laser ablation with MHz pulse frequency at room temperature in air. Nanoparticles agglomerate by fusion, and form interweaving fibrous structures that show certain degree of self-assembly. It is found that there is a threshold-like pulse frequency at which fibrous nanoparticle aggregates start to form. The growth mechanism can be explained by existing theories regarding nanoparticle formation through femtosecond laser ablation. The threshold pulse frequency is in good agreement with the time to start nanoparticle formation, which has been derived numerically by previous analyses.
Characteristics of directly modulated ROF link for wireless access
Authors: Fernando Xavier , Sesay Abu B.
Published: July 2021

The radio-over-fiber (ROF) link is of much interest to
provide broadband wireless access. In this paper, we discuss some
characteristics of a directly modulated ROF link in CDMA and FDMA environments.
These RF measurement results show that, though the ROF link has adequate bandwidth
to support several radio channels, nonlinear distortion and power loss, mainly
due to electrical to optical conversion process and vice versa, limit the
performance. Especially, the AM-PM type nonlinearity that starts at low power
levels is a bigger concern. Furthermore, the spurious free dynamic range (SFDR)
decreases because the increases with the bandwidth of the RF signal.
Adaptive time-stepping using control theory for the Chemical Langevin Equation
Authors: Ilie Silvana , Morshed Monjur
Published: July 2021

Stochastic modeling of biochemical systems has been the subject of intense research in recent years due to the large number of important applications of these systems. A critical stochastic model of well-stirred biochemical systems in the regime of relatively large molecular numbers, far from the thermodynamic limit, is the chemical Langevin equation. This model is represented as a system of stochastic differential equations, with multiplicative and noncommutative noise. Often biochemical systems in applications evolve on multiple time-scales; examples include slow transcription and fast dimerization reactions. The existence of multiple time-scales leads to mathematical stiffness, which is a major challenge for the numerical simulation. Consequently, there is a demand for efficient and accurate numerical methods to approximate the solution of these models. In this paper, we design an adaptive time-stepping method, based on control theory, for the numerical solution of the chemical Langevin equation. The underlying approximation method is the Milstein scheme. The adaptive strategy is tested on several models of interest and is shown to have improved efficiency and accuracy compared with the existing variable and constant-step methods.
Degradation and Loss of Antibacterial Activity of Commercial Amoxicillin with TiO2/WO3-Assisted Solar Photocatalysis
Authors: Arce-Sarria Augusto , Machuca-Martínez Fiderman , Bustillo Lecompte Ciro , Hernández-Ramírez Aracely , Colina-Márquez José
Published: July 2021

In this study, a TiO2 catalyst, modified with tungsten oxide (WO3), was synthesized to reduce its bandgap energy (Eg) and to improve its photocatalytic performance. For the catalyst evaluation, the effect of the calcination temperature on the solar photocatalytic degradation was analyzed. The experimental runs were carried out in a CPC (compound parabolic collector) pilot-scale solar reactor, following a multilevel factorial experimental design, which allowed analysis of the effect of the calcination temperature, the initial concentration of amoxicillin, and the catalyst load on the amoxicillin removal. The most favorable calcination temperature for the catalyst performance, concerning the removal of amoxicillin, was 700 °C; because it was the only sample that showed the rutile phase in its crystalline structure. Regarding the loss of the antibiotic activity, the inhibition tests showed that the treated solution of amoxicillin exhibited lower antibacterial activity. The highest amoxicillin removal achieved in these experiments was 64.4% with 100 ppm of amoxicillin concentration, 700 °C of calcination temperature, and 0.1 g L−1 of catalyst load. Nonetheless, the modified TiO2/WO3 underperformed compared to the commercial TiO2 P25, due to its low specific surface and the particles sintering during the sol-gel synthesis
Shift Work and Obesity among Canadian Women: A Cross-Sectional Study Using a Novel Exposure Assessment Tool
Authors: McGlynn Natalie , Kirsh Victoria  A. , Cotterchio Michelle , Harris M. Anne , Nadalin Victoria , Kreiger Nancy
Published: July 2021

Background/Objectives

It has been suggested that the association between shift work and chronic disease is mediated by an increase in obesity. However, investigations of the relationship between shift work and obesity reveal mixed findings. Using a recently developed exposure assessment tool, this study examined the association between shift work and obesity among Canadian women from two studies: a cohort of university alumni, and a population-based study.
Methods

Self-administered questionnaire data were used from healthy, currently employed females in a population-based study, the Ontario Women’s Diet and Health case-control study (n = 1611 controls), and from a subset of a of university alumni from the Canadian Study of Diet, Lifestyle, and Health (n = 1097) cohort study. Overweight was defined as BMI=25 to <30, and obesity as BMI=30. Reported occupation was converted to occupational codes and linked to a probability of shift work value derived from Survey of Labour and Income Dynamics data. Regular evenings, nights, or rotating work comprised shift work. Polytomous logistic regression estimated the association between probability of shift work, categorized as near nil, low, medium, and high probability of shift work, on overweight and obesity, controlling for detected confounders.
Results

In the population-based sample, high probability of shift work was associated with obesity (reference = near nil probability of shift work, OR: 1.88, 95% CI: 1.01–3.51, p = 0.047). In the alumni cohort, no significant association was detected between shift work and overweight or obesity.
Conclusions

As these analyses found a positive association between high probability of shift work exposure and obesity in a population-based sample, but not in an alumni cohort, it is suggested that the relationship between shift work and obesity is complex, and may be particularly susceptible to occupational and education-related factors within a given population.
Dominating Biological Networks
Authors: Bonato Anthony , Milenković Tijana , Pržulj Nataša , Memišević Vesna
Published: July 2021

Proteins are essential macromolecules of life that carry out most cellular processes. Since proteins aggregate to perform function, and since protein-protein interaction (PPI) networks model these aggregations, one would expect to uncover new biology from PPI network topology. Hence, using PPI networks to predict protein function and role of protein pathways in disease has received attention. A debate remains open about whether network properties of “biologically central (BC)” genes (i.e., their protein products), such as those involved in aging, cancer, infectious diseases, or signaling and drug-targeted pathways, exhibit some topological centrality compared to the rest of the proteins in the human PPI network.

To help resolve this debate, we design new network-based approaches and apply them to get new insight into biological function and disease. We hypothesize that BC genes have a topologically central (TC) role in the human PPI network. We propose two different concepts of topological centrality. We design a new centrality measure to capture complex wirings of proteins in the network that identifies as TC those proteins that reside in dense extended network neighborhoods. Also, we use the notion of domination and find dominating sets (DSs) in the PPI network, i.e., sets of proteins such that every protein is either in the DS or is a neighbor of the DS. Clearly, a DS has a TC role, as it enables efficient communication between different network parts.

We find statistically significant enrichment in BC genes of TC nodes and outperform the existing methods indicating that genes involved in key biological processes occupy topologically complex and dense regions of the network and correspond to its “spine” that connects all other network parts and can thus pass cellular signals efficiently throughout the network. To our knowledge, this is the first study that explores domination in the context of PPI networks.
Quantitative Ultrasound Characterization of Tumor Cell Death: Ultrasound-Stimulated Microbubbles for Radiation Enhancement
Authors: Karshafian Raffi , Kim Hyunjung Christina , Al-Mahrouki Azza , Gorjizadeh Alborz , Sadeghi-Naini Ali , Czarnota Gregory  J.
Published: July 2021

The aim of this study was to assess the efficacy of quantitative ultrasound imaging in characterizing cancer cell death caused by enhanced radiation treatments. This investigation focused on developing this ultrasound modality as an imaging-based non-invasive method that can be used to monitor therapeutic ultrasound and radiation effects. High-frequency (25 MHz) ultrasound was used to image tumor responses caused by ultrasound-stimulated microbubbles in combination with radiation. Human prostate xenografts grown in severe combined immunodeficiency (SCID) mice were treated using 8, 80, or 1000 µL/kg of microbubbles stimulated with ultrasound at 250, 570, or 750 kPa, and exposed to 0, 2, or 8 Gy of radiation. Tumors were imaged prior to treatment and 24 hours after treatment. Spectral analysis of images acquired from treated tumors revealed overall increases in ultrasound backscatter intensity and the spectral intercept parameter. The increase in backscatter intensity compared to the control ranged from 1.9±1.6 dB for the clinical imaging dose of microbubbles (8 µL/kg, 250 kPa, 2 Gy) to 7.0±4.1 dB for the most extreme treatment condition (1000 µL/kg, 750 kPa, 8 Gy). In parallel, in situ end-labelling (ISEL) staining, ceramide, and cyclophilin A staining demonstrated increases in cell death due to DNA fragmentation, ceramide-mediated apoptosis, and release of cyclophilin A as a result of cell membrane permeabilization, respectively. Quantitative ultrasound results indicated changes that paralleled increases in cell death observed from histology analyses supporting its use for non-invasive monitoring of cancer treatment outcomes.
Risk of human papillomavirus-related cancers among kidney transplant recipients and patients receiving chronic dialysis - an observational cohort study
Authors: Dalgaard Lars Skov , Fassel Ulrik , Østergaard Lars Jørgen , Jespersen Bente , Søgaard Ole Schmeltz , Jensen-Fangel Søren
Published: July 2021

Background
Individuals with end-stage renal disease (ESRD) have excess risk of various cancer types. However, the total burden of human papillomavirus-related cancers remains unknown.

Methods
We performed a nationwide observational cohort study during 1994–2010.

For each person with ESRD, we sampled 19 population controls (without ESRD) matched on age, gender and municipality. Participants were followed until first diagnosis of human papillomavirus-related cancer, death, emigration, or 31 December 2010, whichever came first.

Human papillomavirus-related cancers were extracted from Danish medical administrative databases. We considered cancers of the cervix, vulva, vagina, penis, anus, and subsets of head and neck cancers as human papillomavirus-related. We calculated incidence rates of human papillomavirus-related cancer and used Poisson regression to identify risk factors for human papillomavirus-related cancer.

Results
Among 12,293 persons with ESRD and 229,524 population controls we identified 62 and 798 human papillomavirus-related cancers, respectively. Incidence rates of human papillomavirus-related- cancer were 102 per 100,000 person-years (95% confidence interval [CI]; 79.5-131) among persons with ESRD and 40.8 per 100,000 person-years (95% CI; 38.1-43.7) among population controls. ESRD patients had 4.54 (95% CI, 2.48-8.31) fold increased risk of anal cancer and 5.81 fold (95% CI; 3.36-10.1) increased risk of vulvovaginal cancer. Adjusted for age, comorbidity, and sex, ESRD patients had 2.41 (95% CI; 1.83-3.16) fold increased risk of any human papillomavirus-related cancer compared with population controls. Compared with dialysis patients renal transplant recipients had an age-adjusted non-significant 1.53 (95% CI, 0.91-2.58) fold higher risk of human papillomavirus-related cancer.

Conclusions
Persons with ESRD have excess risk of potentially vaccine-preventable human papillomavirus-related cancers.
Privacy concerns and self-disclosure in private and public uses of social media
Authors: Gruzd Anatoliy , Hernández-García Ángel
Published: July 2021

The study contributes to the ongoing debate about the ‘privacy paradox’ in the context of using social media. The presence of a privacy paradox is often declared if there is no relationship between users’ information privacy concerns and their online self-disclosure. However, prior research has produced conflicting results. The novel contribution of this study is that we consider public and private self-disclosure separately. The data came from a cross-national survey of 1,500 Canadians. For the purposes of the study, we only examined the subset of the 545 people who had at least one public account and one private account. Going beyond a single view of self-disclosure, we captured five dimensions of self-disclosure: Amount, Depth, Polarity, Accuracy, and Intent; and two aspects of privacy concerns : concerns about organizational and social threats. To examine the collected data, we used Partial Least Squares Structural Equation Modeling (PLS-SEM). Our research does not support the presence of a privacy paradox as we found a relationship between privacy concerns from organizational and social threats and most of the dimensions of self-disclosure (even if the relationship was weak). There was no difference between patterns of self-disclosure on private versus public accounts. Different privacy concerns may trigger different privacy protection responses and, thus, may interact with self-disclosure differently. Concerns about organizational threats increase awareness and accuracy while reducing amount and depth, while concerns about social threats reduce accuracy and awareness while increasing amount and depth.

Keywords: social media, privacy paradox, private vs public, information privacy, self-disclosure
Synchrony in Broadband Fluctuation and the 2008 Financial Crisis
Authors: Lin Der Chyan
Published: July 2021

We propose phase-like characteristics in scale-free broadband processes and consider fluctuation synchrony based on the temporal signature of significant amplitude fluctuation. Using wavelet transform, successful captures of similar fluctuation pattern between such broadband processes are demonstrated. The application to the financial data leading to the 2008 financial crisis reveals the transition towards a qualitatively different dynamical regime with many equity price in fluctuation synchrony. Further analysis suggests an underlying scale free “price fluctuation network” with large clustering coefficient.
The Role of Visibility in Pursuit/Evasion Games
Authors: Kehagias Athanasios , Mitsche Dieter , Prałat Paweł
Published: July 2021

The cops-and-robber (CR) game has been used in mobile robotics as a discretized model (played on a graph G) of pursuit/evasion problems. The “classic” CR version is a perfect information game: the cops’ (pursuer’s) location is always known to the robber (evader) and vice versa. Many variants of the classic game can be defined: the robber can be invisible and also the robber can be either adversarial (tries to avoid capture) or drunk (performs a random walk). Furthermore, the cops and robber can reside in either nodes or edges of G. Several of these variants are relevant as models or robotic pursuit/evasion. In this paper, we first define carefully several of the variants mentioned above and related quantities such as the cop number and the capture time. Then we introduce and study the cost of visibility (COV), a quantitative measure of the increase in difficulty (from the cops’ point of view) when the robber is invisible. In addition to our theoretical results, we present algorithms which can be used to compute capture times and COV of graphs which are analytically intractable. Finally, we present the results of applying these algorithms to the numerical computation of COV.
AMP-Activated Protein Kinase Regulates the Cell Surface Proteome and Integrin Membrane Traffic
Authors: Antonescu Costin , Ross Eden , Ata Rehman , Thavarajah Thanusi , Medvedev Sergei , Bowden Peter , Marshall John G.
Published: July 2021

The cell surface proteome controls numerous cellular functions including cell migration and adhesion, intercellular communication and nutrient uptake. Cell surface proteins are controlled by acute changes in protein abundance at the plasma membrane through regulation of endocytosis and recycling (endomembrane traffic). Many cellular signals regulate endomembrane traffic, including metabolic signaling; however, the extent to which the cell surface proteome is controlled by acute regulation of endomembrane traffic under various conditions remains incompletely understood. AMP-activated protein kinase (AMPK) is a key metabolic sensor that is activated upon reduced cellular energy availability. AMPK activation alters the endomembrane traffic of a few specific proteins, as part of an adaptive response to increase energy intake and reduce energy expenditure. How increased AMPK activity during energy stress may globally regulate the cell surface proteome is not well understood. To study how AMPK may regulate the cell surface proteome, we used cell-impermeable biotinylation to selectively purify cell surface proteins under various conditions. Using ESI-MS/MS, we found that acute (90 min) treatment with the AMPK activator A-769662 elicits broad control of the cell surface abundance of diverse proteins. In particular, A-769662 treatment depleted from the cell surface proteins with functions in cell migration and adhesion. To complement our mass spectrometry results, we used other methods to show that A-769662 treatment results in impaired cell migration. Further, A-769662 treatment reduced the cell surface abundance of β1-integrin, a key cell migration protein, and AMPK gene silencing prevented this effect. While the control of the cell surface abundance of various proteins by A-769662 treatment was broad, it was also selective, as this treatment did not change the cell surface abundance of the transferrin receptor. Hence, the cell surface proteome is subject to acute regulation by treatment with A-769662, at least some of which is mediated by the metabolic sensor AMPK.
Information seeking behaviors, attitudes, and choices of academic mathematicians
Authors: Gordon Ian D. , Cameron Brian , Chaves Debbie , Hutchinson Rebecca
Published: July 2021

Mathematicians in academic institutions utilize a variety of resources and strategies to seek, find, and use scholarly information and news. Using a sample of mathematicians, researchers surveyed 112 students and faculty at four Canadian university institutions to explore self-perceived success rates, resources consulted, databases used, use of social media, and citation management systems. Further, 12 follow-up interviews were completed with mathematicians to better interpret survey results, resulting information-seeking behaviors, choices, strategies, and feelings on keeping up to date with information needs. According to survey results, a minority of mathematicians (12.5 percent) acknowledged that they were successfully keeping up to date. However, a significant number of mathematicians (28.6 percent) indicated that they were unsuccessful and could do better in remaining current with information needs. Co-investigators, using qualitative analyses, identified four emergent themes related to remaining current: (1) The “slower pace of math” pervades all aspects of this discipline;” (2) There are “too many papers – and not enough time” to effectively search, evaluate, and read scholarly papers of interest; (3) Mathematicians collectively acknowledge that they are open to strategies and technologies where they “could do better” keeping up to date; and (4) Mathematicians have divided loyalties using databases when searching for information by means of “MathSciNet in a Google world.” Additional insights document how mathematicians are guided by mathematical peculiarities and discipline-specific practices. This study helps to shed light on opportunities for academic librarians to identify and meet mathematicians’ evolving information needs.
Keywords: Mathematicians, information-seeking behaviors, information needs, information sources, graduate students, faculty, academic (university) libraries, knowledge management
Automatic landmark point detection and tracking for human facial expressions
Authors: Tie Yun , Guan Ling
Published: July 2021

Facial landmarks are a set of salient points, usually located on the corners, tips or mid points of the facial components. Reliable facial landmarks and their associated detection and tracking algorithms can be widely used for representing the important visual features for face registration and expression recognition. In this paper we propose an efficient and robust method for facial landmark detection and tracking from video sequences. We select 26 landmark points on the facial region to facilitate the analysis of human facial expressions. They are detected in the first input frame by the scale invariant feature based detectors. Multiple Differential Evolution-Markov Chain (DE-MC) particle filters are applied for tracking these points through the video sequences. A kernel correlation analysis approach is proposed to find the detection likelihood by maximizing a similarity criterion between the target points and the candidate points. The detection likelihood is then integrated into the tracker’s observation likelihood. Sampling efficiency is improved and minimal amount of computation is achieved by using the intermediate results obtained in particle allocations. Three public databases are used for experiments and the results demonstrate the effectiveness of our method.
Differential impact of parental region of birth on negative parenting behavior and its effects on child mental health: Results from a large sample of 6 to 11 year old school children in France
Authors: Kovess-Masfety Viviane , Husky Mathilde , Pitrou Isabelle , Fermanian Christophe , Shojaei Taraneh , Chee Christine Chan , Siddiqi Arjumand , Beiser Morton
Published: July 2021

In France, one in 10 residents has immigrated mainly from North Africa, West Africa or the Caribbean including the French West Indies. However little is known about how parents from these regions behave when they migrate to countries that have different cultural norms. It is therefore important to determine how ethno-cultural background affects parental behavior and subsequent child mental health in the context of immigration. The objectives are: 1) to compare negative parenting behaviors of French residents from diverse ethno-cultural backgrounds 2) to examine the relationship between parental region of origin and child mental health, and 3) to investigate the extent to which ethno-cultural context moderates the effect of parenting styles on child mental health.

Methods
A cross-sectional study was conducted in 2005 in 100 schools in South-East France. The Dominic Interactive and the parent-reported Strengths and Difficulties Questionnaire were used to assess child psychopathology. The Parent Behavior and Attitude Questionnaire was used to assess parenting styles. The final sample included data on 1,106 mother and child dyads.

Results
Caring and punitive attitudes were significantly different across mothers as a function of region of origin. This association was stronger for punitive attitudes with the highest prevalence in the Caribbean/African group, while mothers from Maghreb were more similar to French natives. Differences in caring behaviors were similar though less pronounced. Among children of Maghrebian descent, punitive parenting was associated with an increased risk of internalizing disorders while this association was weaker among children of African and Afro-Caribbean descent.

Conclusions
Parental region of origin is an important component of both parenting styles and their effect on child mental health. Interventions on parenting should consider both the region of origin and the differential impact of origin on the effect of parenting styles, thus allowing for a finer-grained focus on high-risk groups.
The Influence of Telepathology on Coordination Practices
Authors: Meyer Julien , Paré Guy
Published: July 2021

Background: Coordination between physicians and allied professionals is essential to the effective delivery of care services and is associated with positive patient outcomes. As information technology can radically transform how professionals collaborate, both researchers and health care accreditation bodies are devoting a growing interest to the means of achieving better coordination.
Introduction: The primary aim of this study is to explain the extent to which and how coordination practices between pathologists, technologists, and surgeons are transformed when telepathology is being implemented.
Materials and Methods: An interpretive case study was conducted. A total of 60 semi-structured interviews with key participants were conducted, in addition to several days of direct observation of telepathology-based intraoperative consultations (IOC).
Results: Three major kinds of transformation of coordination practices were observed. First, the telepathology system itself constrains and disrupts coordination routines, such as the presentation of slides. Second, anticipating IOC, proactively performed by the laboratory personnel in traditional settings, requires more formal requests in a telepathology context. Third, local technologists become more autonomous in performing complex macroscopy manipulations and managing the laboratory, tasks traditionally performed by pathologists.
Conclusions: Successful coordination of work in a telepathology-based IOC context requires that significant transformations be anticipated and accounted for. Project managers need to formalize new work processes, support the transformations in professional roles and mitigate the major hindrances that small material changes may have on work routines.
Incorporating Germanium Oxide into the Glass Phase of Novel Zinc/Magnesium-Based GPCs Designed for Bone Void Filling: Evaluating Their Physical and Mechanical Properties
Authors: Khader Basel A. , Rodríguez Omar , Towler Mark R.
Published: July 2021

The structural role of Germanium (Ge), when substituting for Zinc (Zn) up to 8 mol % in the 0.48SiO2–0.12CaO–0.36ZnO–0.04MgO glass series, was investigated with respect to both the glass chemistry and also the properties of glass polyalkenoate cements (GPCs) manufactured from them. The Network connectivity (NC) of the glass was calculated to increase from 1.83 to 2.42 with the addition of GeO2 (0–8 mol %). Differential thermal analysis (DTA) results confirmed an increase in the glass transition temperature (Tg) of the glass series with GeO2 content. X-ray photoelectron spectroscopy (XPS) showed an increase in the ratio of bridging oxygens (BO) to non-bridging oxygens (NBO) with the addition of GeO2, supporting the NC and DTA results. 29Si magic angle spinning nuclear magnetic resonance spectroscopy (29Si MAS-NMR) determined a chemical shift from −80.3 to −83.7 ppm as the GeO2 concentration increased. These ionomeric glasses were subsequently used as the basic components in a series of GPCs by mixing them with aqueous polyacrylic acid (PAA). The handling properties of the GPCs resulting were evaluated with respect to the increasing concentration of GeO2 in the glass phase. It was found that the working times of these GPCs increased from 3 to 15 min, while their setting times increased from 4 to 18 min, facilitating the injectability of the Zn/Mg-GPCs through a 16-gauge needle. These Ge-Zn/Mg-GPCs were found to be injectable up to 96% within 12 min. Zn/Mg-GPCs containing GeO2 show promise as injectable cements for use in bone void filling.
Effects of wake shapes on high-lift system aerodynamic predictions
Authors: Bissonnette William , Bramesfeld Götz
Published: July 2021

High-lift devices are commonly modelled using potential flow methods at the conceptual design stage. Often, these analyses require the use of prescribed wake shapes in order to avoid numerical stability issues. The wake type used, however, has an impact on the absolute aerodynamic load predictions, which is why, in general, these methods are used to assess performance changes due to configuration variations. Therefore, a study was completed that compared the predicted aerodynamic performance changes of such variations of high-lift configurations using different wake types. Lift and induced drag results are compared with the results that were obtained using relaxed wakes and various prescribed wake shapes. Specific attention is given to predictions of performance changes due to changes in geometry. It was found that models with wakes that are prescribed below the freestream direction yield the best results when investigating performance changes due to flap deflections and flap-span changes. The effect of flap-gap sizes is best evaluated using a fully-relaxed model. The numerically most stable approach of wakes that are prescribed leaving the trailing edge upwards seems to be least reliable in predicting performance changes.

Keywords: potential flow; wake model; high-lift
Interventions to Address Social Connectedness and Loneliness for Older Adults: A Scoping Review
Authors: O’Rourke Hannah M. , Collins Laura , Sidani Souraya
Published: July 2021

Background
Older adults are at risk for loneliness, and interventions to promote social connectedness are needed to directly address this problem. The nature of interventions aimed to affect the distinct, subjective concepts of loneliness/social connectedness has not been clearly described. The purpose of this review was to map the literature on interventions and strategies to affect loneliness/social connectedness for older adults.
Cross-Country Differences in Basal and Stress-Induced Cortisol Secretion in Older Adults
Authors: Fiocco Alexandra , Souza-Talarico Juliana  N. , Plusquellec Pierrich , Lupien Sonia  J. , Suchecki Deborah
Published: July 2021

Objective: Several studies have emphasized the association between socioeconomic status (SES) and inadequate response of the biological stress system. However, other factors related to SES are rarely considered, such as cultural values, social norms, organization, language and communication skills, which raises the need to investigate cross-country differences in stress response. Although some studies have shown differences in cortisol levels between immigrants and natives, there is no cross-country evidence regarding cortisol levels in country-native elders. This is particularly important given the high prevalence of stress-related disorders across nations during aging. The current study examined basal diurnal and reactive cortisol levels in healthy older adults living in two different countries.
Methods: Salivary cortisol of 260 older adults from Canada and Brazil were nalyzed. Diurnal cortisol was measured in saliva samples collected at home throughout two working days at awakening, 30 min after waking, 1400 h, 1600 h and before bedtime. Cortisol reactivity was assessed in response to the Trier Social Stress Test (TSST) in both populations.
Results

Our results showed that even under similar health status, psychological and cognitive characteristics, Brazilian elders exhibited higher basal and stress-induced cortisol secretion compared to the Canadian participants.
Conclusion: These findings suggest that country context may modulate cortisol secretion and could impact the population health.
Hereditary Cancer in Clinical Practice
Authors: Lubiński Jan , Sijmons Rolf H , Scott Rodney J
Published: July 2021

We are proud to announce the re-launch of Hereditary Cancer in Clinical Practice (HCCP). Moving from a classical printed journal, first published in 2003, to the open access, online format of BioMed Central will allow for a quicker and much wider distribution of published articles. Further improving exposure of articles, the journal has also been accepted for indexing by PubMed, and is now on track to receive it's first Impact Factor in 2010 after being accepted for inclusion in Thomson Reuters' Science Citation Index Expanded and the Journal Citation Reports. In addition, the Editorial Board of the journal has been expanded in acknowledgement of the continuing growth of the field of clinical cancer genetics.

Much has changed since December 2003 when the first paper issue of HCCP was published. New genes and syndromes have been identified, more molecular pathways have been unraveled, and new knowledge on therapeutic and preventive options has been gained. However, the reasons for publishing HCCP remain unchanged: to contribute to the improvement of care for individuals and families who are genetically predisposed to develop cancer. As before, this journal will try to cover relevant topics from multiple perspectives, including those of researchers and medical practitioners from different parts of the world who may have different scientific interests and medical priorities. We also remain dedicated to support the international discussion on important topics by sending out questionnaires to the field and publishing their results.

We invite you and your colleagues to submit your manuscripts to HCCP, ranging from small but illustrative case reports to larger scientific studies. In addition to these types of articles, the reader may expect to see meeting reports, reviews and commentaries to highlight new developments and existing controversies in the field.

We hope you will enjoy reading the new Hereditary Cancer in Clinical Practice.
The Survival Effect in Memory: Does It Hold into Old Age and Non-Ancestral Scenarios?
Authors: Yang Lixia , Lau Karen  P.L. , Truong Linda
Published: July 2021

The survival effect in memory refers to the memory enhancement for materials encoded in reference to a survival scenario compared to those encoded in reference to a control scenario or with other encoding strategies [1]. The current study examined whether this effect is well maintained in old age by testing young (ages 18–29) and older adults (ages 65–87) on the survival effect in memory for words encoded in ancestral and/or non-ancestral modern survival scenarios relative to a non-survival control scenario. A pilot study was conducted to select the best matched comparison scenarios based on potential confounding variables, such as valence and arousal. Experiment 1 assessed the survival effect with a well-matched negative control scenario in both young and older adults. The results showed an age-equivalent survival effect across an ancestral and a non-ancestral modern survival scenario. Experiment 2 replicated the survival effect in both age groups with a positive control scenario. Taken together, the data suggest a robust survival effect that is well preserved in old age across ancestral and non-ancestral survival scenarios.
Context and Cardiovascular Risk Modification in Two Regions of Ontario, Canada: A Photo Elicitation Study
Authors: Angus Jan E. , Rukholm Ellen , Michel Isabelle , Larocque Sylvie , Seto Lisa , Lapum Jennifer L. , Timmermans Katherine , Chevrier-Lamoureux Renée , Nolan Robert P.
Published: July 2021

Cardiovascular diseases, which include coronary heart diseases (CHD), remain the leading cause of death in Canada and other industrialized countries. This qualitative study used photo-elicitation, focus groups and in-depth interviews to understand health behaviour change from the perspectives of 38 people who were aware of their high risk for CHD and had received information about cardiovascular risk modification while participating in a larger intervention study. Participants were drawn from two selected regions: Sudbury and District (northern Ontario) and the Greater Toronto Area (southern Ontario). Analysis drew on concepts of place and space to capture the complex interplay between geographic location, sociodemographic position, and people‟s efforts to understand and modify their risk for CHD. Three major sites of difference and ambiguity emerged: 1) place and access to health resources; 2) time and food culture; and 3) itineraries or travels through multiple locations. All participants reported difficulties in learning and adhering to new lifestyle patterns, but access to supportive health resources was different in the two regions. Even within regions, subgroups experienced different patterns of constraint and advantage. In each region, “fast” food and traditional foods were entrenched within different temporal and social meanings. Finally, different and shifting strategies for risk modification were required at various points during daily and seasonal travels through neighbourhoods, to workplaces, or on vacation. Thus health education for CHD risk modification should be place-specific and tailored to the needs and resources of specific communities.
Externalism, Memory, and Self-Knowledge
Authors: Kraay Klaas
Published: July 2021

Externalism holds that the individuation of mental content depends on factors external to the subject. This doctrine appears to undermine both the claim that there is a priori self-knowledge, and the view that individuals have privileged access to their thoughts. Tyler Burge’s influential inclusion theory of self-knowledge purports to reconcile externalism with authoritative self-knowledge. I first consider Paul Boghossian’s claim that the inclusion theory is internally inconsistent. I reject one line of response to this charge, but I endorse another. I next suggest, however, that the inclusion theory has little explanatory value.
Exploring differences in Canadian adult men and women with Diabetes management: results from the Canadian Community Health Survey
Authors: De Melo Margaret , de Sa Eric , Gucciardi Enza
Published: July 2021

Background
Over two million Canadians are known to have diabetes. In addition to the economic burden placed on the healthcare system, the human cost associated with diabetes poses a heavy burden on those living with diabetes. The literature shows that apparent differences exist in diabetes complications and diabetes management between men and women. How self-care management and utilization of health services differ by sex is not clearly understood.

The purpose of this study was to explore sex differences in diabetes self-care and medical management in the Canadian population, using a nationally representative sample.

Methods
Data collected from the cross-sectional, population-based Canadian Community Health Survey (2007–2008) were used in these analyses. A bootstrap variance estimation method and bootstrap weights provided by Statistics Canada were used to calculate 95% confidence intervals. Bivariate analyses identified variables of interest between females and males that were used in subsequent multivariate analyses.

Results
A total of 131,959 respondents were surveyed for the years of 2007 and 2008, inclusive. Fully adjusted multinomial and logistic regression analyses revealed sex differences for those living with diabetes. Compared to men with diabetes, women were more likely to be in the lowest income quintiles than the highest (OR: 1.8, 95% CI: 1.3-2.6) and were more likely not to have a job in the previous week (OR: 1.8, 95% CI: 1.4-2.4). Women were also more likely to avoid foods with fats or high calories (OR: 2.1, 95% CI: 1.4-3.0 and OR: 2.2, 95% CI: 1.6-3.0, respectively), to be concerned about heart disease (OR: 1.6, 95% CI: 1.1-2.2), and to be non-smokers (OR: 2.2, 95% CI: 1.6-3.0). However, despite their increased concern, women checked their blood-glucose less frequently on a daily basis than men (μwomen = 1.7, 95% CI: 1.7-1.8; μmen = 3.1, 95% CI: 2.9-3.2). Women were more likely to have an anxiety disorder (OR: 2.3, 95% CI: 1.7-3.2) and a mood disorder (OR: 2.4, 95% CI: 1.8-3.1), and more likely to be physically inactive (OR: 1.5, 95% CI: 1.2-1.8).

Conclusions
Our findings underscore the importance of addressing sex differences which may interfere with diabetes self-care. In women, addressing socioeconomic and psychological barriers, as well as limitations to active living are important; in men, the benefit of more effective nutrition therapy and smoking cessation interventions are suggested. The results for this study highlight the need to further investigate and eliminate disparities between the sexes in order to optimize health outcomes among Canadians with diabetes.
Caught between a rock and a hard place: mental health of migrant live-in caregivers in Canada
Authors: Vahabi Mandana , Wong Josephine
Published: July 2021

Background
Canada depends on Temporary Foreign Workers (TFWs), also known as migrant workers, to fill labour shortage in agriculture, hospitality, construction, child/senior care, and other low-skilled occupations. Evidence shows that TFWs, especially women live-in caregivers (LC), constitute a vulnerable population. Their health is compromised by the precarious and harsh working and living conditions they encounter. There is a paucity of research on the mental health of LCs, their support systems and access to mental health services.
Method
In this community-based exploratory study, we used mixed methods of survey and focus groups to explore the work related experiences and mental health of migrant live-in caregivers in the Greater Toronto Area in Ontario, Canada. Convenience and snowball sampling were used to recruit participants. The inclusion criteria were: being 18 years or older, initially migrated to Canada as TFWs under LC program, resided in the Greater Toronto Area, and able to understand and converse in English based on self-report. This paper reports on the focus group results derived from inductive thematic analysis.
Results
A total of 30 women LCs participated in the study. Most of them were from the Philippines. A number of key themes emerged from the participants’ narratives: (1) precarious migration-employment status (re)produces exploitation; (2) deskilling and downward social mobility reinforce alienation; (3) endurance of hardship for family back home; (4) double lives of public cheerfulness and private anguish; and (4) unrecognized mental health needs. The study results reflected gross injustices experienced by these women.
Conclusion
A multi-faceted approach is required to improve the working and living conditions of this vulnerable group and ultimately their health outcomes. We recommend the following: government inspection to ensure employer compliance with the labour standards and provision of safe working and living conditions; change immigration policy to allow migrant caregivers to apply for permanent residence upon arrival; the TFWs Program to establish fair wages and subsidized housing so that caregivers can truly access the live-out option; and local ethno-specific, settlement and faith organizations be leveraged to provide TFWs with social support as well as information about their rights and how to access health and social care.
Investigation of the influencing factors in odor emission from wet-end white water
Authors: HUANG SHANCONG , DOU SHENG , DING MINGQI , XIA XINXING
Published: July 2021

Emission of malodorous gases, such as volatile organic compounds (VOCs), hydrogen sulfide (H2S), and ammonia (NH3) during pulping and papermaking has caused certain harm to the air environment and human health. This paper investigated the influencing factors of odor emission from wet-end white water during the pro-duction of bobbin paper in a papermaking mill using old corrugated containers (OCC) as raw material.
The concentration of malodorous gases emitted from wet-end white water was determined with pump-suction gas detectors. The results indicated that low temperature could limit the release of malodorous gases from white water.
Specifically, no total volatile organic compounds (TVOC), H2S, and NH3 was detected at a temperature of 15°C. The concentrations of malodorous gases were slightly increased when temperature increased to 25°C. When temperature
was 55°C, the released concentrations of TVOC, H2S, and NH3 were 22.3 mg/m3, 5.91 mg/m3, and 2.78 mg/m3, respectively. Therefore, the content of malodorous gases significantly increased with the temperature increase. The stirring of white water accelerated the release of malodorous gases, and the release rate sped up as the stirring speed increased. However, the total amount of malodorous gases released were basically the same as the static state. Furthermore, the higher the concentration of white water, the greater the amount of malodorous gases released. The pH had little influence on the TVOC release, whereas it significantly affected the release of H2S and NH3. With the increase of pH value, the released amount of H2S and NH3 gradually decreased. When pH reached 9.0, the release amount of H2S and NH3 was almost zero, proving that an alkaline condition inhibits the release of H2S and NH3.