bluuebunny/crossref_metadata_2025 huggingface dataset:
What makes a simulation-based learning environment for preservice teachers authentic? The role of individual learning characteristics and context-related features
Authors: Stürmer Kathleen , Fütterer Tim , Kron Stephanie , Sommerhoff Daniel , Ufer Stefan
Published: May 2024

To support professional competence development in teacher education, learning environments should allow learners to engage with professional tasks. It is crucial for knowledge and skill transfer in such learning environments to real-life context that preservice teachers perceive the task as authentic. However, due to a lack of prior knowledge, novices may have difficulties in recognizing relevant elements of practice. It is thus assumed that different factors may guide their perception of task authenticity independently of the task that has to be mastered. Such factors could be, for example, overt design features of the learning environments on a physical level or the familiarity with the learning context and learning prerequisites, which act as important links for knowledge acquisition. In this study, preservice teachers’ perception of task authenticity is contrasted between two implementation types (video vs. role-play) of the same simulation aiming to foster diagnostic competence. The two types differ in approximating real-life practice concerning the professional task that has to be mastered. In an experimental, longitudinal study, N = 119 mathematics preservice teachers participated online in one type of the simulation four times during one semester (n = 66 video, n = 53 role-play). Perceived task authenticity was higher for the video simulation type and increased with repeated participation in the simulation independently of the implementation type. Further, preservice teachers’ task utility value positively influenced their perception of task authenticity. The results illustrate the role of learning prerequisites as well as familiarity with the task for novices’ perception. Also, they could be an initial indication that, depending on the level of learners’ professional development, the way of approximating real-life practice in simulations might influence the perception of task authenticity.
Robust Automated Tumour Segmentation Network Using 3D Direction-Wise Convolution and Transformer
Authors: Chu Ziping , Singh Sonit , Sowmya Arcot
Published: May 2024

Semantic segmentation of tumours plays a crucial role in fundamental medical image analysis and has a significant impact on cancer diagnosis and treatment planning. UNet and its variants have achieved state-of-the-art results on various 2D and 3D medical image segmentation tasks involving different imaging modalities. Recently, researchers have tried to merge the multi-head self-attention mechanism, as introduced by the Transformer, into U-shaped network structures to enhance the segmentation performance. However, both suffer from limitations that make networks under-perform on voxel-level classification tasks, the Transformer is unable to encode positional information and translation equivariance, while the Convolutional Neural Network lacks global features and dynamic attention. In this work, a new architecture named TCTNet Tumour Segmentation with 3D Direction-Wise Convolution and Transformer) is introduced, which comprises an encoder utilising a hybrid Transformer-Convolutional Neural Network (CNN) structure and a decoder that incorporates 3D Direction-Wise Convolution. Experimental results show that the proposed hybrid Transformer-CNN network structure obtains better performance than other 3D segmentation networks on the Brain Tumour Segmentation 2021 (BraTS21) dataset. Two more tumour datasets from Medical Segmentation Decathlon are also utilised to test the generalisation ability of the proposed network architecture. In addition, an ablation study was conducted to verify the effectiveness of the designed decoder for the tumour segmentation tasks. The proposed method maintains a competitive segmentation performance while reducing computational effort by 10% in terms of floating-point operations.
Estimating kill intervals for a specific prey species using location clusters from GPS-collared Eurasian lynx (Lynx lynx)
Authors: Vogt Kristina , Roth Tobias , Signer Sven , Willisch Christian Simon , Amrhein Valentin
Published: May 2024

An increasing number of GPS telemetry studies have helped to gain important insights into predator-prey relationships in recent years. However, considerable time and effort is needed to evaluate whether GPS location clusters (GLCs) reflect predation events. To reduce field effort, predictive models are being developed to calculate predator kill intervals, but few studies have attempted to do this for a specific species of prey. Between 2013 and 2018, we studied predation by 13 GPS-collared Eurasian lynx (Lynx lynx) on Alpine chamois (Rupicapra rupicapra) in the northwestern Swiss Alps. Our objectives were to predict the total number of killed chamois, including potential kills in unchecked GLCs, and to evaluate if model predictions were sufficiently accurate. We built a set of generalized linear models (GLM) predicting the occurrence of GLCs containing lynx-killed chamois (1) versus GLCs containing other prey types or no prey (0) and compared their predictive performance by means of k-fold cross-validation. We found that model performance was very similar for all candidate models, with the full model yielding the best cross-validation result (accuracy = 0.83, sensitivity = 0.43, specificity = 0.94). Female lynx killed on average one chamois every 11.9 days (10.6–13.0 days, 95% CI); male lynx killed one chamois every 7.2 days (6.7–7.6 days, 95% CI). Our model showed high specificity for detecting non-chamois GLCs, but sensitivity for detection of GLCs with actual chamois kills was low. We conclude that the sensitivity of the models should be further improved, but the results can be sufficient for practical application. Predictive modelling approaches do not replace extensive fieldwork but require large sets of field data, high individual variability and thorough knowledge of a predator’s ecology and prey community. Our approach may provide useful results for binary classifications in rather simple predator-prey systems, but extrapolations from one study system to another might be difficult.
Fermatean fuzzy sets and its extensions: a systematic literature review
Authors: Büyüközkan Gülçin , Uztürk Deniz , Ilıcak Öykü
Published: May 2024

The Fermatean Fuzzy Set (FFS) theory emerges as a crucial and prevalent tool in addressing uncertainty across diverse domains. Despite its recognized utility in managing ambiguous information, recent research lacks a comprehensive analysis of key FFS areas, applications, research gaps, and outcomes. This study, conducted through the Scientific Procedures and Rationales for Systematic Literature Reviews (SPAR-4-SLR) protocol, delves into an exploration of the FFS literature, reviewing 135 relevant articles. The documents are meticulously analyzed based on their integrated methodologies, Aggregation Operators (AOs), linguistic sets, and extensions. Additionally, a thematic analysis, facilitated by the Bibliometrix tool, is presented to provide nuanced insights into future research directions and crucial areas within the literature. The study unveils valuable findings, including the integration of linguistic variables with interval-valued FFS, fostering robust environments for dynamic decision-making—a mere glimpse of the potential directions for future research. The gaps and future directions section further articulates recommendations, offering a structured foundation for researchers to enhance their understanding of FFS and chart future studies confidently.
Long-term prospective outcome data using EndoPredict as risk stratification and chemotherapy decision biomarker in hormone receptor-positive, HER2-negative early breast cancer
Authors: Klein Evelyn , Kiechle Marion , Josipovic Adriana , Anders Sophie-Isabelle , Noske Aurelia , Mogler Carolin , Hapfelmeier Alexander , Ettl Johannes
Published: May 2024

Purpose

To report the prospective long-term outcome data of patients whose chemotherapy decision was guided by the EndoPredict test.

Methods

Patients with hormone receptor-positive HER2-negative early breast cancer with 0–3 positive lymph nodes were enrolled. The EndoPredict test was carried out on all tumor samples. Treatment compliance, local recurrence, distant metastases, and survival were evaluated. Associations of EPclin risk stratification with 5-year disease-free survival and distant metastasis-free survival were evaluated by time-to-event analysis.

Results

368 consecutive patients were included in the analysis. Median follow-up was 8.2 years. EndoPredict allocated 238 (65%) in the low-risk and 130 (35%) patients in the high-risk group. Risk for disease recurrence or death in EPclin high-risk patients was twofold higher than in EPclin low-risk patients (hazard ratio [HR] 2.08; 95% CI 1.26–3.44; p = 0.004). EPclin low-risk patients had a 5-year disease-free survival of 95.3% (95% CI 92.6–98.0%). EPclin high-risk patients were at higher risk of developing distant metastases or death (HR 2.21; 95% CI 1.27–3.88; p = 0.005). EPclin high-risk patients who underwent chemotherapy had a 5-year DFS of 89.1% (95% CI 82.7–96.1%) in contrast to high-risk patients without chemotherapy (68.9%; 95% CI 56.2–84.5%; HR 0.46; 95% CI 0.23–0.95; p = 0.036). EPclin high-risk patients were at higher risk of experiencing distant metastases or death than EPclin low-risk patients regardless of menopausal status (premenopausal: HR 3.55; 95% CI 1.17–12.32; p = 0.025; postmenopausal: HR 1.92; 95% CI 0.99–3.7; p = 0.054).

Conclusion

EndoPredict can guide decisions on adjuvant chemotherapy in early luminal breast cancer. EndoPredict risk stratification is also applicable in premenopausal women.
Liquid penetration in hydrophobised cellulose based sheets
Authors: Nicasy R. J. K. , Waldner C. , Erich S. J. F. , Adan O. C. G. , Hirn U. , Huinink H. P.
Published: May 2024

Controlling the liquid transport within cellulose-based materials is crucial for numerous applications, including printing, bio-assays, packaging, and cleaning. To control liquid transport and quality, post-processes such as calendering, a way of compressing and smoothen the paper using hard pressure rollers, and hydrophobisation, are commonly employed. To understand how these processes influence liquid uptake, this study uses an Ultra-Fast Imaging (UFI) NMR method to analyse moisture profiles during liquid uptake in various cellulose-based paper sheets with diverse levels of hydrophobisation and calendering. It is demonstrated that calendering decreases penetration speed and increases swelling. The reduction in penetration speed could be linked to a decrease in permeability upon calendering, as measured by the Gurley air permeance. Additionally, it is observed that hydrophobisation delayed and slowed down liquid uptake in the paper samples, and, in extreme cases, completely altered the liquid uptake phenomena. With substantial hydrophobisation, liquid penetration no longer proceeded with a well-defined liquid front but exhibited huge levels of fingering. Furthermore, is was observed that within highly hydrophobised paper, fibres were first prewetted, initiating a first swelling, before the pores between fibres could be filled. Subsequently, water could enter the pores between, allowing fibre bonds to be broken, leading to a second swelling of the paper sheet. The improved understanding will contribute to better control of the flow within cellulose-based materials, benefiting applications such as printing, packaging and microfluidics.
Parental Stress and Quality of Life in Parents of Young Children with Autism
Authors: Dijkstra-de Neijs Leanne , Boeke Daphne B. , van Berckelaer-Onnes Ina A. , Swaab Hanna , Ester Wietske A.
Published: May 2024

Parents of children with ASD are at risk for chronic stress due to challenging parenting. It is unknown whether stress is already present in early parenthood, similar for mothers and fathers and if this impacts quality of life (QoL). Parental stress and QoL were assessed in 56 mothers and 51 fathers of young children (aged 3 to 7) with autism. Associations between parental stress (OBVL) and QoL (WHOQoL-BREF) were examined. Parents of young children with ASD appear to have high parental stress from conflicting feelings towards their child and from difficulties with parenting. Mothers have higher stress from feeling confined in their motherly role than fathers compared to the OBVL norm population. Both mothers and fathers have a low QoL. Increased maternal conflicting feelings towards the child associated with lower psychological QoL, while high maternal feelings of role confinement associated with low physical QoL. Increased paternal conflicting feelings towards their child related to lower physical and social QoL, while fathers with more parenting difficulties reported less satisfaction with their psychological and environmental wellbeing. Thus, already at young age, parenting children with ASD is a major challenge for both mothers and fathers.
Occupational Therapy in Psychiatric Short-Term Hospitalization Units: Scoping Review
Authors: García-Gestal Uxia , Talavera-Valverde Miguel-Ángel , Souto-Gómez Ana-Isabel
Published: May 2024

Given the context, the overarching aim is to identify scientific publications on occupational therapy in Psychiatric-Short-Term-Hospitalization-Units. Specific objectives include: (a) Analyzing the historical development of this research area; (b) Synthesizing existing evidence on the nature of documentary sources on occupational therapy in in Psychiatric-Short-Term-Hospitalization-Units; (c) Detailing the volume of scientific literature on occupational therapy in these units; (e) Evaluating available evidence on occupational therapy interventions to improve functionality, quality of life, and recovery in individuals admitted to in Psychiatric-Short-Term-Hospitalization-Units. A scoping review method was employed to conduct a historical mapping of research on in Psychiatric-Short-Term-Hospitalization-Units. The review proceeded in five stages following PRISMA guidelines. After applying selection criteria, the search identified 446 references. Findings are presented under three headings: (a) Historical trends in the scientific literature on occupational therapy and in Psychiatric-Short-Term-Hospitalization-Units; (b) Nature and volume of articles included in the occupational therapy synthesis in Psychiatric Short-Term Hospitalization Units; (c) Data extraction on methodological variables in the research of occupational therapy articles in in Psychiatric-Short-Term-Hospitalization-Units; and (d) Data extraction on research outcome variables of occupational therapy articles in Psychiatric Short-Term Hospitalization Units. The growth of occupational therapy in in Psychiatric-Short-Term-Hospitalization-Units is emphasized, with an increase in qualitative studies. Occupational therapy is underscored as an integral part of care, supporting the diversity and effectiveness of interventions. Common diagnoses include schizophrenia and depressive disorders. Group interventions and the spiritual dimension positively influence the quality of care and meaningful routines for recovery in in Psychiatric-Short-Term-Hospitalization-Units.
Effects of Low Emission Zones on Air Quality, New Vehicle Registrations, and Birthweights: Evidence from Japan
Authors: Nishitateno Shuhei , Burke Paul J.
Published: May 2024

In October 2003 four contiguous prefectures in Greater Tokyo introduced Low Emission Zones (LEZs) from which diesel trucks and buses without particulate filters have been banned from entering. This paper analyzes the effects of this large-scale intervention on air quality, new vehicle registrations, and birthweights. We use a matching approach to construct a control group comparable to the designated areas in terms of propensity scores based on municipality characteristics during the pre-intervention period and apply a difference-in-differences design. We find evidence that the intervention led to reductions in hourly particulate matter concentrations and the incidence of low birthweights in the Greater Tokyo LEZ relative to the control group. We also find that the LEZs led to increases in registrations of new trucks and buses. This is not the case for passenger cars, which were exempt from the regulations. Our paper provides the first evidence of a significant link between LEZs and reduced incidence of low birthweights.
There’s power in the community: a sociomaterial analysis of university learning spaces
Authors: Griffiths Teri-Lisa , Dickinson Jill
Published: May 2024

Internationally, the significance of the relationship between the university environment and the student experience is well-documented. In response, UK university leaders have driven forward policies that focus on estates’ expansion and regeneration. The restrictions necessitated by the COVID-19 pandemic presented an opportunity to explore questions around the importance of the materiality of campus and its impact on the student experience. This case study examines students’ experiences over time within a post-1992 UK university during the 2020/2021 academic year and makes a tri-fold contribution. First, it explores how restrictions placed on learning spaces can foreground the relationship(s) between space and learning practice. Second, through adopting a sociomateriality perspective, the paper examines students’ reactions to the top-down approach taken to Higher Education (HE) policymaking, and the potential for exposing manifestations of power within the student experience. Third, the paper illustrates how photovoice methodology can encourage reflections on the impact of materiality on the student experience. The findings reveal two principal themes: power dynamics and community participation. The authors make recommendations for university leaders to adopt a community-first, co-creation approach towards future policymaking that enables meaningful dialogue with students and educators and drives forward sustainable, inclusive change.
Environment, intraspecific lineages and geographic range jointly shape the high morphological variability of Dikerogammarus villosus (Sowinsky, 1894) (Crustacea, Amphipoda): a successful aquatic invader across Europe
Authors: Podwysocki Krzysztof , Bącela-Spychalska Karolina , Desiderato Andrea , Rewicz Tomasz , Copilaş-Ciocianu Denis
Published: May 2024

Phenotypic variability is a key factor promoting the establishment and spread of invasive populations in new environments. The Ponto-Caspian region contains a diverse endemic fauna known for its exceptional environmental plasticity, with many species invading European waters. However, the extent to which the environment shapes the phenotypic variability of these successful invaders remains poorly understood. We test to what extent the environment, intraspecific lineage affinity and geographic range interact and shape the variability of ecologically relevant functional morphological traits of the amphipod, Dikerogammarus villosus. Our results show the highest differentiation among environments, with an enhancement of predation-related traits in brackish waters relative to freshwaters. Differentiation among lineages and ranges (native/invaded) was smaller, occurring in traits related to locomotion and food processing. Although we uncovered an overall increase in variability outside the native range, the dynamics of morphological change were lineage-specific: the Western Lineage (invading via the River Danube) underwent a shift towards increased appendage length, while the Eastern Lineage (invading via the River Dnieper) underwent a significant overall morphospace expansion. We conclude that D. villosus exhibits a remarkable morphological variability across Europe that is influenced by the interplay between the environment as well as its evolutionary and invasion history.
Exploring Digital Competencies: Validation and Reliability of an Instrument for the Educational Community and for all Educational Stages
Authors: Soriano-Alcantara Jesús Manuel , Guillén-Gámez Francisco D. , Ruiz-Palmero Julio
Published: May 2024

Digital competencies are very significant in terms of integrating digital resources into educational processes. This study presents the validity and reliability of an instrument created by Carrera et al. (2011), in order to evaluate the basic digital competence of the three main educational agents of the educational community (teachers, students, and parents) for all educational stages (Early Childhood Education, Primary Education, Secondary Education and Higher Education), making use of digital resources to (1) Skills in management and transfer of technological data, (2) Software and hardware skills, (3) Web navigation skills, (4) Skills in using word processors, (5) Data processing and management skills, y (6) Multimedia presentation design skills. The application of the instrument was carried out with a sample of 1,149 participants from all educational stages, coming from the entire territory of the Dominican Republic. Reliability was assessed using various measures, including Cronbach’s Alpha, Spearman-Brown Coefficient, Guttman’s Two Halves, McDonald’s Omega, and composite reliability. To validate the instrument, exploratory factor analysis (EFA) and confirmatory factor analysis (CFA) were carried out with the purpose of understanding the validity and dimensionality of the scale (comprehension validity, construct validity, convergent, discriminant and invariance validity). The results demonstrated highly satisfactory reliability, and in terms of construct validity, a good fit of the model was observed, valid for any educational agent and for any educational stage. The final version of the instrument consists of 20 items classified into six latent factors.
Potential factors-embedding group recommendation for online education
Authors: Yang Qing , Wang Yifeng , Wu Zezheng , Zhang Jingai , Liu Lianhai , Zhang Jingwei
Published: May 2024

Online education platform urgently needs recommendation methods to service learning groups. The existing group recommendation methods rely on member preference aggregation. However, potential factors such as teachers and schools have an important impact on the decision-making of learning groups. Due to the different ways in which potential factors operate, it is very challenging to model the impact these potential factors have on groups. In this paper, we propose a group recommendation method for online education (GEMst) that innovatively designs two modules to capture different types of potential factor embedding. In the subjective guidance module, we construct a heterogeneous information network based on the relationship between guiders (teacher, leader, etc.) and groups, analyze the influence of the guider on the group, and obtain the group representation from this perspective. In the objective environment hypergraph module, we consider the influence mode of the environment (school, platform, etc.) on the group, and propose the objective relationship hypergraph convolution. Compared with hypergraph convolution, it directly learns the influence between groups in the same environment. We provide information fusion strategies that GEMst can collaboratively consider group members’ opinions and the impact of potential factors. In addition, to enhance the learning effect of the model, we design a pre-training strategy based on the user grouping relationship that obtains more accurate user embedding representations. We test GEMst on two real-world datasets, and the results show that GEMst outperforms the current baseline group recommendation method.
Fucoidans from Laminaria hyperborea demonstrate bactericidal activity against diverse bacteria
Authors: Beagan Michael L. C. , Bang Line L , Pettersen Jens S. , Grønnemose Rasmus B. , Foertsch Sebastian , Andersen Thomas E. , Ding Ming
Published: May 2024

Fucoidans are a heterogenous class of fucose-rich sulfated carbohydrates which have attracted increasing attention in cancer and inflammation research due to their bioactive properties. There are reports that fucoidans may have direct antibacterial effects and synergy with antibiotics. However, the literature is conflicting, potentially due to the limited reporting of origin, characteristics, and extraction methods of the fucoidans tested. Here we report the results of 18 defined fucoidans screened for direct, indirect, and synergistic antibacterial effects. 15 distinct fucoidan fractions, isolated from Laminaria hyperborea using a solvent-free extraction process, were characterised for molecular weight, pH, viscosity, and sulfur content. These, together with three commercially available crude fractions, were assessed at concentrations from 0.03125-24 mg mL-1 for minimum inhibitory concentration against Staphylococcus aureus, Streptococcus mutans and Streptococcus sanguinis. Furthermore, we tested a selection of fucoidans for antibacterial synergy with vancomycin and indirect antibacterial effects in whole blood survival assays. Reverse-transcription quantitative polymerase chain reaction (RT-qPCR) was performed to assess the stress response in fucoidan-treated S. aureus cultures. We have identified one fucoidan fraction with bactericidal activity against diverse bacteria. This effect is dose-, fucoidan fraction- and bacteria-specific, and furthermore, not related to osmotic stress. No synergistic effects were observed with fucoidan in combination vancomycin. Fucoidans have exciting potential as antimicrobial agents. Further analysis is required to establish the precise molecular characteristics responsible for their potent bactericidal activity.
Mealtime Skill Independence: from Pouch-to-Spoon Fading to Using Chopsticks
Authors: Taylor Tessa
Published: May 2024

Compared to solids, less paediatric feeding research has targeted liquids, medication, and teaching independence skills (e.g., fork, chopsticks). No research to our knowledge has reported transitioning from spout squeeze ‘baby food’ pouches, increasing finger-feeding, and teaching steps in scooping, sipping, and biting off portions. We detail a clinical case and depict data teaching comprehensive mealtime independence using multi-element and multiple-baseline designs. A 3-year-old male with paediatric feeding disorder, avoidant/restrictive food intake disorder (ARFID), and autism spectrum disorder (level 3) had only one independent skill (yogurt pouch via spout). He did not finger-feed, self-spoon-feed, self-drink, or cup-drink. He participated in a home-based intensive 2-week behaviour-analytic treatment programme. We conducted an assessment comparing novel pouch transition apparatuses, then used pouch-to-spoon fading to teach spoon self-feeding. We taught independence in finger-feeding, open-cup drinking, and four methods of medication administration, then open-cup bolus sipping, self-scooping, biting off portions, fork, and chopsticks (11 skills). He met 100% of goals. Caregivers reported high social validity and relevant culturally significant information, and gains generalised and maintained in follow-up.
Use of a Modified Threshold Function in Fuzzy Cognitive Maps for Improved Failure Mode Identification
Authors: Augustine Manu , Yadav Om Prakash , Nayyar Ashish , Joshi Dheeraj
Published: May 2024

Fuzzy cognitive maps (FCMs) provide a rapid and efficient approach for system modeling and simulation. The literature demonstrates numerous successful applications of FCMs in identifying failure modes. The standard process of failure mode identification using FCMs involves monitoring crucial concept/node values for excesses. Threshold functions are used to limit the value of nodes within a pre-specified range, which is usually [0, 1] or [-1, + 1]. However, traditional FCMs using the tanh threshold function possess two crucial drawbacks for this particular.Purpose(i) a tendency to reduce the values of state vector components, and (ii) the potential inability to reach a limit state with clearly identifiable failure states. The reason for this is the inherent mathematical nature of the tanh function in being asymptotic to the horizontal line demarcating the edge of the specified range. To overcome these limitations, this paper introduces a novel modified tanh threshold function that effectively addresses both issues.
A comparison of global flood models using Sentinel-1 and a change detection approach
Authors: Risling Axel , Lindersson Sara , Brandimarte Luigia
Published: May 2024

Advances in numerical algorithms, improvement of computational power and progress in remote sensing have led to the development of global flood models (GFMs), which promise to be a useful tool for large-scale flood risk management. However, performance and reliability of GFMs, especially in data-scarce regions, is still uncertain, as they are difficult to validate. Here we aim at contributing to develop alternative, more flexible, and consistent methods for GFM validation by applying a change detection analysis on synthetic aperture radar (CD-SAR) imagery obtained from the Sentinel-1 imagery, on a cloud-based geospatial analysis platform. The study addresses two main objectives. First, to validate four widely adopted GFMs with flood maps generated through the proposed CD-SAR approach. This exercise was conducted for eight different large river basins on four continents, to account for a diverse range of hydro-climatic environments. Second, to compare CD-SAR-derived flood maps with those obtained from alternative remote sensing sources. These comparative results offer valuable insights into the reliability of CD-SAR data as a validation tool, more specifically how it stacks up against flood maps generated by other remote sensing techniques.
Scintillation analysis of gaussian beams in anisotropic and uniaxial media
Authors: Basdemir Husnu Deniz , Elmabruk Kholoud
Published: May 2024

Scintillation of Gaussian beams both in anisotropic and uniaxial media is examined numerically utilizing the split step approach. Both the point-like and the power scintillation indices of Gaussian beams that propagate for a 5 Km in anisotropic and uniaxial media are investigated. The effect of turbulence strength on the scintillation level is also studied. In this regard, the scintillation level of the three components of Gaussian beam both the anisotropic and the uniaxial are analysed and compared with the scintillation of the fundamental Gaussian beam. The provided results show that the x-component of the Gaussian beam as propagate in both the anisotropic and the uniaxial media has the lowest scintillation. In addition, in uniaxial medium, the three components of the Gaussian beam have a power scintillation level less than the fundamental Gaussian.
A news-based economic policy uncertainty index for Nigeria
Authors: Salisu Afees , Salisu Sulaiman , Salisu Subair
Published: May 2024

In this study, we develop the first daily news-based Economic Policy Uncertainty (EPU) index for Nigeria, which was previously not covered in recent EPU indices. The need to track economic uncertainties in Nigeria becomes crucial for investment and policy, especially with the renewed interest in the country as an important investment destination. To construct the EPU index, we use relevant keywords from articles in prominent newspapers in the country, covering the aftermath of the global financial crisis and the COVID pandemic, with a data scope of January 2010 to November 2022. We evaluate the predictability of the index by examining its connection with economic and financial variables like exchange rates, stock prices, and inflation in Nigeria. The results are robust to alternative model specifications, data frequencies, and multiple forecast horizons. We hope to extend this exercise to other useful indices, including Geopolitical Risk, Financial Stress Indicators, and Monetary Policy Uncertainty, which are not readily available for Africa, including Nigeria.
Biochar from co-pyrolysis of biological sludge and woody waste followed by chemical and thermal activation: end-of-waste procedure for sludge management and biochar sorption efficiency for anionic and cationic dyes
Authors: Bakari Zaineb , Fichera Michelangelo , El Ghadraoui Ayoub , Renai Lapo , Giurlani Walter , Santianni Daniela , Fibbi Donatella , Bruzzoniti Maria Concetta , Del Bubba Massimo
Published: May 2024

Nine biochars were produced by co-pyrolysis of sawdust and biological sludge following the “design of experiment” approach. Two kinds of sludge (both deriving from the treatment of mixed industrial-municipal wastewater) and two types of woody waste were selected as categorical predicting variables, while contact time, pyrolysis temperature, and sludge percentage were used as quantitative variables. Biochars were analysed for their product characteristics and environmental compatibility based on the European Standards (EN 12915–1:2009) for materials intended for water treatment (i.e. ash content, water leachable polycyclic aromatic hydrocarbons (PAHs) and elements), as well as for specific surface area (SSA), using them as response variables of a multivariate partial least square multiple regression, whose results provided interesting insights on the relationships between pyrolysis conditions and biochar characteristics. Biochars produced with sludge and/or providing the highest SSA values (258–370 m2 g−1) were selected to undergo a sustainable chemical treatment using a by-product of the gasification of woody biomass, complying in all cases with European Standards and achieving therefore the end-of-waste status for sewage sludge. The biochar deriving from the highest percentage of sludge (30% by weight) and with the highest SSA (390 m2 g−1) was thermally activated achieving SSA of 460 m2 g−1 and then tested for the sorption of direct yellow 50 and methylene blue in ultrapure water and real wastewater, compared to a commercial activated carbon (AC). The biochar showed Langmuir sorption maxima (Qm) 2–9 times lower than AC, thus highlighting promising sorption performances. Qm for methylene blue in wastewater (28 mg‧g−1) was confirmed by column breakthrough experiments.
Intensive antihypertensive treatment does not lower cerebral blood flow or cause orthostatic hypotension in frail older adults
Authors: Weijs Ralf W. J. , de Roos Bente M. , Thijssen Dick H. J. , Claassen Jurgen A. H. R.
Published: May 2024

This study aimed to examine the effects of intensive antihypertensive treatment (AHT), i.e., systolic blood pressure target ≤ 140 mmHg, on cerebral blood flow, cerebral autoregulation, and orthostatic hypotension, in a representative population of frail older adults. Fourteen frail hypertensive patients (six females; age 80.3 ± 5.2 years; Clinical Frailty Scale 4–7; unattended SBP ≥ 150 mmHg) underwent measurements before and after a median 7-week AHT targeting SBP ≤ 140 mmHg. Transcranial Doppler measurements of middle cerebral artery velocity (MCAv), reflecting changes in cerebral blood flow (CBF), were combined with finger plethysmography recordings of continuous BP. Transfer function analysis assessed cerebral autoregulation (CA). ANCOVA analysed AHT-induced changes in CBF and CA and evaluated non-inferiority of the relative change in CBF (margin: -10%; covariates: pre-AHT values and AHT-induced relative mean BP change). McNemar-tests analysed whether the prevalence of OH and initial OH, assessed by sit/supine-to-stand challenges, increased with AHT. Unattended mean arterial pressure decreased by 15 mmHg following AHT. Ten (71%) participants had good quality TCD assessments. Non-inferiority was confirmed for the relative change in MCAv (95%CI: -2.7, 30.4). CA remained normal following AHT (P > 0.05), and the prevalence of OH and initial OH did not increase (P ≥ 0.655). We found that AHT in frail, older patients does not reduce CBF, impair autoregulation, or increase (initial) OH prevalence. These observations may open doors for more intensive AHT targets upon individualized evaluation and monitoring of hypertensive frail patients.

Clinical Trial Registration: This study is registered at ClinicalTrials.gov (NCT05529147; September 1, 2022) and EudraCT (2022-001283-10; June 28, 2022).
Genome integrity as a potential index of longevity in Ashkenazi Centenarian’s families
Authors: Andrawus Mariana , David Gil Ben , Terziyska Ivana , Sharvit Lital , Bergman Aviv , Barzilai Nir , Raj Srilakshmi M. , Govindaraju Diddahally R. , Atzmon Gil
Published: May 2024

The aging process, or senescence, is characterized by age-specific decline in physical and physiological function, and increased frailty and genomic changes, including mutation accumulation. However, the mechanisms through which changes in genomic architecture influence human longevity have remained obscure. Copy number variants (CNVs), an abundant class of genomic variants, offer unique opportunities for understanding age-related genomic changes. Here we report the spectrum of CNVs in a cohort of 670 Ashkenazi Jewish centenarians, their progeny, and unrelated controls. The average ages of these groups were 97.4 ± 2.8, 69.2 ± 9.2, and 66.5 ± 7.0 respectively. For the first time, we compared different size classes of CNVs, from 1 kB to 100 MB in size. Using a high-resolution custom Affymetrix array, targeting 44,639 genomic regions, we identified a total of 12,166, 22,188, and 10,285 CNVs in centenarians, their progeny, and control groups, respectively. Interestingly, the offspring group showed the highest number of unique CNVs, followed by control and centenarians. While both gains and losses were found in all three groups, centenarians showed a significantly higher average number of both total gains and losses relative to their controls (p < 0.0327, 0.0182, respectively). Moreover, centenarians showed a lower total length of genomic material lost, suggesting that they may maintain superior genomic integrity over time. We also observe a significance fold increase of CNVs among the offspring, implying greater genomic integrity and a putative mechanism for longevity preservation. Genomic regions that experienced loss or gains appear to be distributed across many sites in the genome and contain genes involved in DNA transcription, cellular transport, developmental pathways, and metabolic functions. Our findings suggest that the exceptional longevity observed in centenarians may be attributed to the prolonged maintenance of functionally important genes. These genes are intrinsic to specific genomic regions as well as to the overall integrity of the genomic architecture. Additionally, a strong association between longer CNVs and differential gene expression observed in this study supports the notion that genomic integrity could positively influence longevity.
Spanish Adaptation and Psychometric Properties of the Protective Behavioral Strategies for Marijuana Scale: The Protective Behavioral Strategies for Cannabis Scale (S-PBSC)
Authors: Sanchez-Garcia Manuel , Carmona-Márquez José , Bravo Adrian J. , Fernández-Calderón Fermín
Published: May 2024

The Protective Behavioral Strategies for Marijuana scale (PBSM) was initially developed using samples of university students in USA. A community sample of Spanish young adults was recruited to provide the Spanish full-length and short versions of the Protective Behavioral Strategies for Cannabis use (S-PBSC; S-PBSC-SF). We followed a rigorous item-selection process to select the most relevant items from the original 50-item pool developed by Pedersen et al. (2016), on the basis of evidence of reliability, evidence of validity according to the internal structure (factor loadings, invariance across genders and university status, and differential item functioning [DIF]), and evidence of validity based on the relationships between S-PBSC scores and cannabis outcomes. Our findings support a 31-item unidimensional measure and a 13-item short form with excellent fit and internal consistency, invariant across genders and college status and free of DIF. Both the S-PBSC and S-PBSC-SF scores were associated with reduced cannabis use and consequences.
PSFHSP-Net: an efficient lightweight network for identifying pubic symphysis-fetal head standard plane from intrapartum ultrasound images
Authors: Qiu Ruiyu , Zhou Mengqiang , Bai Jieyun , Lu Yaosheng , Wang Huijin
Published: May 2024

The accurate selection of the ultrasound plane for the fetal head and pubic symphysis is critical for precisely measuring the angle of progression. The traditional method depends heavily on sonographers manually selecting the imaging plane. This process is not only time-intensive and laborious but also prone to variability based on the clinicians’ expertise. Consequently, there is a significant need for an automated method driven by artificial intelligence. To enhance the efficiency and accuracy of identifying the pubic symphysis-fetal head standard plane (PSFHSP), we proposed a streamlined neural network, PSFHSP-Net, based on a modified version of ResNet-18. This network comprises a single convolutional layer and three residual blocks designed to mitigate noise interference and bolster feature extraction capabilities. The model’s adaptability was further refined by expanding the shared feature layer into task-specific layers. We assessed its performance against both traditional heavyweight and other lightweight models by evaluating metrics such as F1-score, accuracy (ACC), recall, precision, area under the ROC curve (AUC), model parameter count, and frames per second (FPS). The PSFHSP-Net recorded an ACC of 0.8995, an F1-score of 0.9075, a recall of 0.9191, and a precision of 0.9022. This model surpassed other heavyweight and lightweight models in these metrics. Notably, it featured the smallest model size (1.48 MB) and the highest processing speed (65.7909 FPS), meeting the real-time processing criterion of over 24 images per second. While the AUC of our model was 0.930, slightly lower than that of ResNet34 (0.935), it showed a marked improvement over ResNet-18 in testing, with increases in ACC and F1-score of 0.0435 and 0.0306, respectively. However, precision saw a slight decrease from 0.9184 to 0.9022, a reduction of 0.0162. Despite these trade-offs, the compression of the model significantly reduced its size from 42.64 to 1.48 MB and increased its inference speed by 4.4753 to 65.7909 FPS. The results confirm that the PSFHSP-Net is capable of swiftly and effectively identifying the PSFHSP, thereby facilitating accurate measurements of the angle of progression. This development represents a significant advancement in automating fetal imaging analysis, promising enhanced consistency and reduced operator dependency in clinical settings.

Graphical abstract
Growth of Community Outpatient Care in the Veterans Affairs System After the MISSION Act
Authors: Yoon Jean , Gujral Kritee , Dismuke-Greer Clara , Scott Jennifer Y. , Jiang Hao
Published: May 2024

Background

The Maintaining Internal Systems and Strengthening Integrated Outside Networks (MISSION) Act of 2018 authorized a major expansion of purchased care in the community for Veterans experiencing access barriers in the Veterans Affairs (VA) health care system.

Objective

To estimate changes in primary care, mental health, and emergency/urgent care visits in the VA and community fiscal years (FY) 2018–2021 and differences between rural and urban clinics.

Design

A national, longitudinal study of VA clinics and outpatient utilization. Clinic-level analysis was conducted to estimate changes in number and proportion of clinic visits provided in the community associated with the MISSION Act adjusting for clinic characteristics and underlying time trends.

Participants

In total, 1050 VA clinics and 6.6 million Veterans assigned to primary care.

Main Measures

Number of primary care, mental health, and emergency/urgent care visits provided in the VA and community and the proportion provided in the community.

Key Results

Nationally, community primary care visits increased by 107% (50,611 to 104,923), community mental health visits increased by 167% (100,701 to 268,976), and community emergency/urgent care visits increased by 129% (142,262 to 325,407) from the first quarter of 2018 to last quarter of 2021. In adjusted analysis, after MISSION Act implementation, there was an increase in community visits as a proportion of total clinic visits for emergency/urgent care and mental health but not primary care. Rural clinics had larger increases in the proportion of community visits for primary care and emergency/urgent care than urban clinics.

Conclusions

After the MISSION Act, more outpatient care shifted to the community for emergency/urgent care and mental health care but not primary care. Community care utilization increased more in rural compared to urban clinics for primary care and emergency/urgent care. These findings highlight the challenges and importance of maintaining provider networks in rural areas to ensure access to care.
Aqueous removal of Cr(VI) by Citrus sinensis juice-coated multi-walled carbon nanotubes
Authors: Amaku James Friday , Taziwa Raymond
Published: May 2024

A novel adsorbent was prepared from multi-wall carbon nanotubes (MWCNTs) and Citrus sinensis juice extract-modified MWCNTs (OJMW) and characterized using scanning electron microscopy (SEM), Fourier transform infrared spectra (FTIR), X-ray diffractometer (XRD), BET and thermogravimetric analysis. The results showed that the nanotubes exhibited good surface area, pore size, functional groups, and robust stability at elevated temperatures (308 and 313 K). The adsorbent was applied in water for the sequestration of Cr(VI). The adsorption of Cr(VI) on MWCNTs and OJMW was influenced by factors of adsorption. Optimum removal of Cr(VI) was attained at 180 min contact time, 0.05 g adsorbent dose, and solution pH 2 for MWCNTs and OJMW. The kinetic behaviour of the Cr(VI) adsorption onto MWCNTs and OJMW was governed by the pseudo-first-order and pseudo-second-order kinetic model, respectively. The equilibrium data obtained for the uptake of Cr(VI) onto MWCNTs and OJMW fitted satisfactorily with Freundlich and Langmuir isotherm models, respectively. Meanwhile, MWCNTs and OJMW exhibited monolayer adsorption capacities (qmax) of 44.72 and 12.26 g g−1, respectively, at 298 K. The adsorption process was spontaneous and feasible. The direction of energy flow in the uptake of Cr(VI) onto OJMW and MWCNTs followed endothermic and exothermic adsorption processes, respectively. The adsorption–desorption experiments showed that OJMW had good regenerative abilities.