bluuebunny/crossref_metadata_2025 huggingface dataset:
Expansion and Valuation of Naproxen Sodium Fast Dissolving Tablet
Authors:   Department of Pharmaceutical Chemistry, DCS’s ARA College of Pharmacy, Nagaon, Dhule, University of KBC-NMU, Jalgaon, Maharashtra, India, Patil Shailesh B , More Jitendra D
Published: November 2024

The evaluation of Naproxen Sodium Fast Dissolving Tablets emphasizes the critical role of careful formulation design and thorough testing in pharmaceutical development. Among the formulations, F7 demonstrated outstanding properties, including excellent flow characteristics and optimal tablet hardness. Stability testing over a four-week period showed consistent performance, though minor variations in tablet attributes were observed. Continuous monitoring is advised to ensure sustained efficacy. The in-vitro release profile revealed rapid disintegration and dissolution, crucial for prompt drug release. These results highlight the necessity of stringent quality control measures and ongoing optimization to enhance patient outcomes and ensure the reliability of Naproxen Sodium Fast Dissolving Tablets. In a parallel evaluation, the stability and performance of Naproxen Sodium Fast Dissolving Tablets were assessed under various environmental conditions, showing that temperature and humidity significantly impacted Naproxen Sodium concentration and dissolution rates. Formulation F7 emerged as the most promising, offering superior flow properties, compressibility, and dosage consistency. In-vitro tests confirmed rapid disintegration and dissolution, aligning with Pharmacopoeial standards. Four-week stability studies indicated consistent tablet characteristics, with only slight changes in hardness, friability, and drug content. Continued monitoring is recommended to ensure long-term stability and product quality. These findings underscore the importance of rigorous formulation optimization and stability testing to ensure reliable drug release and sustained efficacy.

Keywords

Naproxen Sodium Fast Dissolving Tablets, UV, HPLC, DSC, FT­IR
Strategic Implication Of Globalization On ‘Brain Drain’ In Emerging Economies: South Africa
Authors: Alpheaus Litheko , Faan Pelser
Published: November 2024

The large increase in skilled professional migration between countries in recent years poses new challenges for policymakers. It is important to observe how this phenomenon impacts South Africa due to its unique socio-economic context. One may also reason that as much as globalization has resulted in the easy movement of labor, in the case of South Africa, most of the push factors driving brain drain are a combination of structural and socio-economic dynamics. The aim of the paper is to explore the factors that contribute to the migration of skilled professionals and, furthermore, the long-term implication of brain drain on the sustainable development of the South African economy by collecting pre-existing textual data. Evidence from reviews suggests that globalization has contributed to brain drain in emerging economies. Many emerging markets are experiencing significant human skill losses, which in turn has a negative impact on their development. Furthermore, the reviews have emphasized the contributing factors to the migration of highly skilled professionals to other countries. In addition, findings reveal that the migration of skilled professionals poses a threat to South Africa’s development objectives. To overcome this challenge, it is important to deter skilled professionals from leaving and encourage them to return by addressing concerns like safety and security.
CIRCULAÇÃO E LEGITIMAÇÃO DE SENTIDOS EM EDUCAÇÃO ESPECIAL NA PERSPECTIVA INCLUSIVA: implicações no Curso de Pedagogia (Educação Profissional e Tecnológica) ofertado em Rede por Institutos Federais
Authors: Duarte Neto Grigorio , Ribeiro Francisco Adelton Alves
Published: November 2024

Os conceitos de Formação Discursiva (FD), Formação Ideológica (FI) e Condições de Produção (CP) são apresentados com o intuito de detectar a disseminação e a validação de significados e efeitos de sentidos presentes no Projeto Pedagógico do Curso de Pedagogia - Educação Profissional e Tecnológica (EPT) oferecido em Rede pelo Instituto Federal de Educação, Ciência e Tecnologia do Maranhão (IFMA), em relação à Educação Especial sob a ótica da Inclusão. Para isso, foi realizado o levantamento de informações por meio da formação do Corpus Discursivo de arquivo, a fim de realizar a descrição inicial do dado empírico linguístico em sua profundidade semântica e posteriormente realizar a interpretação, uma vez que a análise começa já na formação do Corpus. Nesta etapa, são utilizados os conceitos da Análise de Discurso de orientação Francesa (AD) com o intuito de estabelecer um referencial teórico ao término da pesquisa. Através da individualizaçãode um referencial teórico-analítico, a Interdiscursividade, o Projeto Pedagógico é entendido como um espaço social de Memória Discursiva, a partir da produção dos sujeitos, como um lugar da linguagem do já mencionado e pré-construído, trazendo a importância da historicidade na formação de alguns dos diversos significados da Educação Especial na perspectiva Inclusiva. Ao analisar as Formações Discursivas (FD) e focar nos principais significados presentes nos textos dos conteúdos programáticos, foi possível identificar a presença de significados ora ligados às posições dominantes, ora às contrárias, através dos mecanismos de paráfrase e polissemia encontrados nos mesmos e em outras evidências linguísticas.
EL MAPA ACTUAL DE LOS HISPANISTAS SERBIOS
Authors: Kovačević Petrović Bojana , Maričić Mesarović Sanja
Published: November 2024

En este artículo presentamos las informaciones fundamentales relacionadas con el desarrollo del hispanismo serbio, con el enfoque en la Facultad de Filosofía y Letras de la Universidad de Novi Sad como la anfitriona de la Tercera Conferencia Nacional de Hispanistas Serbios en 2022. Asimismo, comentamos las mesas redondas sobre las traducciones del español al serbio y los problemas docentes en los tiempos de pandemia. Por último, presentamos la producción científica entre las dos conferencias y proyectos hispánicos internacionales en los cuales participan los investigadores de Serbia. Nuestro texto tiene el objetivo de mostrar la calidad académica, la variedad de las investigaciones, la abundancia de la producción y los éxitos de los hispanistas serbios entre el 2018 y 2022.
A turizmus 1995 és 2021 közötti karbonhatékonyságának vizsgálata hazánkban az egyes üvegházhatású gázok szerinti bontásban
Authors: Kocsis Tímea , Magyar Norbert , Kovácsné Székely Ilona
Published: November 2024

Jelen kutatásban elemeztük az I nemzetgazdasági ág (Szálláshely-szolgáltatás, vendéglátás) karbonhatékonyságának magyarországi alakulását, levetítve azt az egyes üvegházhatású gázokra, amelyeket
a Kiotói Jegyzőkönyv nevesít. A karbonhatékonyság számításához az Eurostat Database-adatait
használtuk. Az egységnyi bruttó hozzáadott értékre fordítandó kibocsátás mennyisége (karbonhatékonyság) jelentősen csökkent a vizsgált időszakban (1995–2021) a szén-dioxid esetében, szignifikáns javulás figyelhető meg a metánkibocsátásra vonatkozóan is. A nitrózus gázok, a perfluorkarbonok, a kén-hexafluorid és a nitrogén-trifluorid nem mutattak szignifikáns változást, míg a fluorozott
szénhidrogének kibocsátását növekvő tendencia jellemezte. Ezek a gázok mint hűtőközegek váltották fel a korábbi, ózonkárosító anyagokat a Montreali Egyezményt követően.
A Covid19-járvány következményei és tanulságai az energiafelhasználás és a hazai termelő ágazatok karbonlábnyomának alakulása terén
Authors: Erőss Viktória , Pálvölgyi Tamás
Published: November 2024

Számos kutatás (Lamb et al., 2021; Le Queré et al., 2020, Liu et al., 2020) eredményei alapján tényként kezelhető, hogy az ipari ágazatok felelősek a globális üvegházhatásúgáz-kibocsátás döntő hányadáért, ebből is az energiatermelés, a feldolgozóipar, a cementgyártás és a mezőgazdaság központi
szerepét a leghangsúlyosabb a környezetterhelés vonatkozásában. Az éghajlatváltozás ütemének lassítását célzó javaslatok egy része a termelés és a fogyasztás mérséklését javasolja, egyetértve ugyanakkor abban, hogy a jelenlegi fogyasztási minták és termelési mozgatórugók egy fenntarthatóbb
irányba történő elmozdítása rendkívül komplex kihívásnak mutatkozik. A Covid19-világjárvány
olyan erőteljes és globális külső hatást jelentett mind a termelés, mind a fogyasztás számára, amely
jelentősen és a környezetterhelés szempontjából kedvező irányba terelte azok volumenét. Éppen ezen
tulajdonsága miatt a világjárvány jelenlétének időszaka nagyban alkalmas annak vizsgálatára, hogyan alakulnak a termelést és a fogyasztást, továbbá az ezekhez kapcsolódó emissziót leíró adatok
és indikátorok – valóban kézenfekvő és egyértelmű megoldást jelent-e a dekarbonizáció terén a termelés és a fogyasztás visszafogása? Tanulmányunk a fentiek tükrében a hazai energiafelhasználás
alakulásának és a termelő ágazatok karbonintenzitása tendenciáinak kvantitatív vizsgálatára irányul,
elsődlegesen a 2020. és a 2021. év változásait kiváltó hatások azonosításának céljával.
Prevalence of malocclusion and craniofacial morphological variations among 7-13-year-old children in Elementary School, Kediri
Authors: Triwardhani Ari , Winoto Ervina Restiwulan , Alida Alida , Pramusita Adya , Iskandar Regina Purnama Dewi , Jordana Jesslyn , Noor Tengku Natasha Eleena binti Tengku Ahmad
Published: November 2024

Background: Craniofacial morphological variations can influence malocclusion. Mesocephalic head tends to form mesoprosopic face and class I malocclusion. Dolicocephalic head tends to form leptoprosopic face and class II malocclusion. Brachycephalic head tends to form euryprosopic face and class III malocclusion. Emphasizing the importance of malocclusion early treatment, research on malocclusion prevalence and craniofacial morphology variations in growing children is needed. Purpose: To determine malocclusion prevalence and craniofacial morphological variations among 7-13-year-old children at Medowo III Elementary School, Kediri. Methods: This descriptive study used 44 samples of Medowo III Elementary School, Kediri students. Head and face length and width were measured using a spreading caliper. The cephalic and facial indices were then determined for the classification of head and facial types. Results: The dominant craniofacial morphological variations in the samples were hyper-brachycephalic head (39 samples) and euryprosopic face (14 samples). The highest prevalence of malocclusion among individuals with hyper-brachycephalic head type was Angle’s class I malocclusion. Class II malocclusion was found in 1 sample, and class III malocclusion in 3 samples. Among the samples with this head type, the most common malocclusion variations were anterior crowding (36 samples), followed by deep bite (15 samples). Conclusion: The highest prevalence of malocclusion among Medowo III Elementary School, Kediri students was Angle class I malocclusion, characterized by specific craniofacial morphological variations, namely hyper-brachycephalic head type and euryprosopic face.
THE EFFECT OF BOOKLET MEDIA HEALTH EDUCATION ON MOTHERS’ KNOWLEDGE ABOUT PICKY EATERS OF PRESCHOOL CHILDREN
Authors: Salsabila Putri Kirana Ajeng , Kusbiantoro Dadang , Aisyah Harnina Samantha
Published: November 2024

Introduction: Picky eating is a behavior that is difficult to eat in children with a strong tendency to be picky about food, consuming less varied food, limiting intake of certain foods, both familiar and new types of food to try. Good maternal knowledge is needed to be able to deal with picky eater behavior in children appropriately and prevent the picky eater problem from getting worse. Lack of knowledge causes limited information as a reference for action. Health education about picky eaters is carried out as an effort to increase mothers' knowledge about picky eaters. Carrying out health education using booklet media will help receive information about picky eaters more optimally. This research aims to analyze the effect of booklet media health education on mothers' knowledge about picky eaters in preschool children. Methods: This research design uses pre-experimental with one group pre-test and post-test. Using total sampling with a population of 40 respondents. The data collection method uses a questionnaire with 20 question items whose validity and reliability have been tested. The questionnaire is suitable to be used to measure mothers' knowledge about picky eaters in preschool children. Results: The results of the research using the Wilcoxon test obtained sig (0.000) <0.05) which means there is an influence on mothers' knowledge about picky eaters before and after health education. Conclusions: Booklet media health education has a significant effect on mothers' level of knowledge about picky eaters in preschool children.
THE EFFECT OF PROGRESSIVE MUSCLE RELAXATION TECHNIQUES ON REDUCING SYSTOLE BLOOD PRESSURE IN ELDERLY PEOPLE WITH HYPERTENSION
Authors: Fauziah Wardah , Mahayu Adiutama Novian , Krisna Teja
Published: November 2024

Introduction: Hypertension is a disease that is often not felt but can have serious consequences for health. One way to prevent and overcome hypertension is using non-pharmacological therapy, one of which is the progressive muscle relaxation technique which is useful for lowering blood pressure. This study aims to analyze the effect of progressive muscle relaxation techniques on reducing systolic blood pressure in elderly people with hypertension. Methods: The method used is quantitative research with a pre-post test quasi-experimental research design with a control group. Sampling using a simple random sampling technique with a total of 60 respondents divided into 2 groups, namely, 30 intervention groups and 30 control groups. Data analysis using the Independent Sample T-test parametric test. Results: The results showed the average value of pre-test blood pressure in the intervention group was 157 mmHg and the control group was 149 mmHg, while in the post-test the intervention group after being given the progressive muscle relaxation technique was 136 mmHg and the control group was 134 mmHg. Data analysis using the Independent Sample T-test test obtained a p-value of 0.000 which indicates the effect of progressive muscle relaxation techniques on the elderly with hypertension. Conclusions: Therefore, it can be concluded that progressive muscle relaxation techniques can have an effect on reducing systolic blood pressure in the elderly with hypertension and it is recommended that this study be used as a reference material and implementation in performing progressive muscle relaxation techniques to prevent and control hypertension.
RELATIONSHIP BETWEEN PATIENT FACTORS AND PSYCHOLOGICAL WELL-BEING IN TYPE 2 DIABETES MELLITUS PATIENTS
Authors: Umam Khotibul , Iswatun Iswatun , Susanto Joko , Sri Wijayanti Endah , Paramadita Yayuk
Published: November 2024

Introduction: Psychological well-being is an individual's feelings about everything from trauma to acceptance of life. Diabetes mellitus is a chronic disease that is a major problem in the world of health and a disease that has the most consequences on physical, psychological, and social. Every type 2 diabetes mellitus patient has a different psychological condition, some have high psychological well-being and some have low psychological well-being. This study aimed to analyze the relationship between patient factors and psychological well-being in type 2 diabetes mellitus patients at the Tikung Lamongan Health Center UPT. Methods: This research method is quantitative with a correlational research design. The sampling technique used consecutive sampling, samples were taken on March 24 - April 2, 2022 at the Tikung Lamongan Health Center UPT with a total of 57 respondents. The instruments used were the SPWB Ryff questionnaire (1995), demographic data, and religiosity questionnaire compiled by Kartika (2017), while the data analysis used the chi-square test from SPSS. Results: The results showed no relationship between patient factors based on age, gender, education, and psychological well-being in patients with type 2 diabetes mellitus because it had an Asymp. Sig. (2-sided) value > 0.05, while patient factors based on religiosity were related to psychological well-being because it had an Asymp. Sig. (2-sided) value of 0.000. Conclusions: This study is expected to increase information and knowledge about efforts to prevent and control type 2 diabetes mellitus so that the psychological well-being that is owned increases.
KNOWLEDGE AND READINESS OF ADOLESCENTS AS PROSPECTIVE BRIDES AND GROOMS IN STUNTING PREVENTION EFFORTS
Authors: Hartati Suryani , Mardhika Amellia , Dwi Retnani Ajeng
Published: November 2024

Introduction: Stunting is currently happening and is a threat to Indonesia. Planning is needed starting from adolescence, having good knowledge and readiness regarding how to prevent having stunted offspring. The target of the Sustainable Development Goals (SDGs) in 2030 includes the second goal, eliminating hunger and all forms of malnutrition and achieving food security, reducing stunting rates by 40% by 2025. The purpose of this study is to analyze the level of knowledge and readiness of adolescents to become prospective brides in an efforts to prevent stunting. Methods: This study uses a survey research design with a sample size of 67 adolescents taken in two cities, DKI Jakarta and Surabaya in 2024. This sampling used purposive sampling. The research variables consist of the knowledge and readiness of adolescents as prospective brides and grooms in efforts to prevent stunting. The instrument used was a questionnaire distributed via Google form distributed by researchers in both areas. The data collected used Spearman rank correlation analysis. Results: There is a relationship between knowledge and the readiness of prospective adolescent brides in efforts to prevent stunting (p=0.001). Conclusions: Health education on stunting, nutritional status, and reproductive health during adolescence must be a mutually supportive program between the Ministry of Health and the Ministry of Education and Culture, both in schools and in integrated “posyandu” that also involve families.
Optimizing Late Blight Management in Ecuadorian Tomato Crops through Potassium Phosphite and Integrated Fungicide Strategies
Authors: Alvarez-Romero Pablo Israel , Román Robalino Daniel Arturo , Mantilla Cabrera Carmen Elena , Lindao Cordova Victor , Hinojosa Sánchez Leonardo Anibal
Published: November 2024

A Late blight is a devastating plant disease affecting solanaceous crops, and fungicides play a crucial role in its management. Nevertheless, the extensive use of fungicides has alowed to the development of fungicide-resistant strains of the causal agent, Phytophthora infestans. Phosphites, a group of innocuous products, have been shown to have direct and indirect results on the development of oomycetes, including P. infestans. This study evaluated the efficacy of different methods, including fungicide rotation and the fungicide mixture with potassium phosphite, in controlling late blight in tomato. Tomato plants were transplanted in the field and subjected to nine different treatments, including various combinations of fungicide rotation, potassium phosphite application, chlorine dioxide, and ozonized water. The results showed that the use of fungicide rotation combined with potassium phosphite applications, at both 7-day and 14-day intervals, significantly reduced the intensity of late blight and increased tomato productivity. The application of phosphites and fungicides with different modes of action, such as Benalaxyl-M, Dimethomorph, Fluazinam, and Propamocarb, was found to be an effective alternative for late blight control in Solanaceae crops. These findings suggest that the integration of fungicide rotation and phosphite application can be a valuable strategy for managing late blight in tomato and other solanaceous crops, potentially reducing the selection pressure for fungicide-resistant P. infestans strains. To enhance the efficacy and sustainability of these treatments, further research should focus on determining the optimal timing and application rates.
Temporal and Spatial Characteristic of Iron In-Use Stocks in Henan Province, China
Authors: Liu Yilei , Wang Shanshan , Li Yeke , Sun Huijie , Zhao Yingying , Zhang Ruiqin
Published: November 2024

With the acceleration of urbanization and industrialization in China, iron in-use stocks (IIUS) are accumulating rapidly. IIUS is potential reservoirs accessible for urban mining and a major source of future renewable energy. So this study used Henan Province as a case to assess IIUS and its spatial distribution at the provincial level in China. In this study, a bottom-up model was used to estimate the temporal characteristics of IIUS, and analyzed the prefecture-level spatial distribution of IIUS in 2021 based on the spatial autocorrelation model. Meanwhile, this study also explored the decoupling between IIUS and economic development using the constructed Tapio-LMDI model and identified the factors affecting the decoupling relationship. The results showed that, 1) Henan Province’s total IIUS reached 474.51 Mt in 2022, increasing by 7.89 times from 2000. The largest contributor of IIUS was building sector, which accounted for 66.89% of the total in 2022. 2) At prefecture-level cities, the density of IIUS varied from 1055.35 to 8855.35 t/km2 in 2021, indicating a signification imbalance in spatial distribution. 3) Moran’ I index for IIUS in Henan Province was 0.47 and the Z-value was 2.75 (P < 0.001), showing a significant spatial positive correlation. 4) There is a Weak-decoupling relationship between IIUS and economy, and technology factor is the main factor to promote decoupling. The government needs to improve the technology to realize the decoupling of IIUS.
Both-Bone Forearm Shaft Fractures Treated with Compression Plate Fixation in Adults
Authors: Vasara Henri , Stenroos Antti , Aspinen Samuli , Kosola Jussi , Anttila Turkka , Nordback Panu H.
Published: November 2024

Background:

Both-bone forearm shaft fractures (BBFFs) in adults carry a significant risk of adverse events (AEs). Based on the current literature, there is considerable variance in AE incidence reporting. We aimed to systematically review the literature on BBFFs in adults treated with compression plate fixation, assessing AEs and long-term outcomes.

Methods:

We performed a systematic review based on the PubMed database on the current literature on adult BBFFs treated with open reduction and internal fixation with compression plates. Two authors independently collected the data, and a third author resolved disagreements between the 2 reviewers. The primary outcome measure was postoperative AEs, whereas the secondary outcome was to review the long-term outcomes. We evaluated the methodological quality of the studies with a modified version of the Coleman Methodology Score.

Results:

Fifteen studies (12 retrospective case series and 3 randomized controlled trials) met the set inclusion criteria. In total, there were 944 patients, of whom 24% (n = 224) experienced some AEs, and 14% had major AEs requiring secondary operations or remaining persistent. The most common AEs were postoperative nerve injuries (incidence 7%, n = 64/944) and fracture nonunion (incidence 5%, n = 45/944). Disabilities of the Arm, Shoulder, and Hand scores were available for 135 patients (5 studies), with a mean score of 12.5 (range 0-61). According to the modified Coleman Methodology Scores, there were 2 good-, 1 fair-, and 12 poor-quality studies among the included studies.

Conclusion:

BBFF compression plate fixation in adults poses a relatively high AE risk (24%). According to available patient-reported outcomes and range of motion measurements, the average postoperative outcomes are good, although a minor disability typically persists to some extent. There is a need for high-quality prospective trials assessing the treatment and outcomes of BBFFs in adults to improve forearm fracture treatment.

Level of Evidence:

Level III. See Instructions for Authors for a complete description of levels of evidence.
Resistencia a antimicrobianos: Causas
Authors: Ruiz Joaquim
Published: November 2024

La resistencia a antimicrobianos es un problema creciente a nivel mundial, con previsiones que hablan de hasta 10 millones de muertes por su causa en el año 2050. Este problema se ve agravado por la escasez de nuevos antimicrobianos, que de manera mayoritaria son miembros de familias ya establecidas, y por tanto frente a los que ya existen mecanismos de resistencia. El desarrollo o selección de resistencia a antimicrobianos, aunque directamente asociado al nivel de uso de los mismos, no es un fenómeno unidimensional. En esta revisión se repasan algunas de las principales causas subyacentes tras este problema.
Pain assessment and treatment in patients with mucopolysaccharidoses: a French multicentric pediatric study
Authors: Blin Mélanie , Tardieu Marine , Lacombe Didier , Gorce Magali , Damaj Léna , Barth Magalie , Genevaz Delphine , Vibet Sophie , LABARTHE Francois
Published: November 2024

Background: Mucopolysaccharidoses (MPS) are a group of rare genetic lysosomal storage disorders with a wide spectrum of clinical severities. Chronic pain is frequent but difficult to assess. The aim of this study was to evaluate the detection and management of pain in pediatric MPS patients.
Methods:Pain-related data were retrospectively collected from the medical records of pediatric MPS patients from five French centers for inborn metabolic disorders. A national online survey was also conducted about the feelingsof patients and/or their families and of healthcare professionals about the detection and management of pain in pediatricMPS patients.
Results: The medical records of 48 patients with all subtypes of MPS were analyzed. Painwas frequent and recurrent in MPS patients (pain was reported in 94% of the patients), but it was undoubtedly difficult to assess. We observed important differences between (1) medical records demonstrating frequent assessment and treatment of pain, (2) feelings of patients or their families (53 questionnaires) reporting frequent pain, and (3) feelings of healthcare professionals (21 questionnaires) who were quite satisfied with their own practices, suggesting that the majority of patients were unpainful. We recommend a more systematic evaluation of pain, particularly for outpatients, with the use of adapted tools, notably in children with disabilities,and with a multidimensional approach to pain assessment and management. Caregiver training is also needed,and close collaboration with pain centers is encouraged.
Conclusion: A routine pain assessment protocol for MPS patients is required that covers the entire spectrum of pain and canbe adapted for every type of patient, including those with neurocognitive and motor impairments.
Education and Music Intervention to Reduce Anxiety (EMIRA) in Cardiac Catheterization: Intervention Development
Authors: Batista Letícia de Carvalho , Salvetti Marina de Góes , Butcher Rita de Cássia Gengo e Silva
Published: November 2024

BACKGROUND Anxiety related to cardiac catheterization (ARCC) is highly prevalent and most severe in the immediate pre-operative period. ARCC is associated with increased myocardial oxygen consumption, blood pressure variability, and increased risk of arrhythmias, leading to higher rates of intraoperative complications and worse physical, emotional, and cognitive functioning.OBJECTIVE To describe a nurse-led complex intervention (CI) designed to reduce ARCC in adults before a cardiac catheterization (CC).METHODS To design the intervention, a concept analysis yielded the identification of ARCC antecedents and attributes, based on which CI components and objectives were determined. For each component, CI procedures, mode of delivery, and dose were established based on empirical evidence. The CI was reported according to the Template for Intervention Description and Replication Checklist.RESULTS The Education and Music Intervention to Reduce Anxiety (EMIRA) consists of two components. The educational component provides the essential information regarding CC purpose, catheterization laboratory features, and what to expect before, during, and after the procedure. The musical component provides individuals with a feeling of comfort and relaxation. EMIRA is delivered in one 30-minute session using an audio-visual format. EMIRA’s expected primary outcome is a decreased state anxiety level. Additionally, EMIRA might reduce blood pressure, heart and respiratory rates, and chest pain.CONCLUSIONS EMIRA is a CI developed with methodological rigor. Future studies should evaluate the acceptability, feasibility, and efficacy of EMIRA.
Regional Differences and Spatial Evolutionary Characteristics of Common Prosperity of Rural Areas and Residents in China
Authors: Huang Yewei , Qiu Junqin
Published: November 2024

As the gap between urban and rural areas in China continues to widen, the government has proposed the goal of bringing common prosperity to rural areas and residents according to Marxist humanitarian ideals. The common prosperity proposed by China is the overall prosperity of material and spiritual life. This study constructs a comprehensive index system to measure and evaluate the level of common prosperity of rural areas and residents in 30 provinces in China using the combined methods of entropy and principal component analysis. The data covered the national and provincial levels. Furthermore, this study uses the natural break and Terrell index decomposition methods to comprehensively evaluate the level of common prosperity of rural areas and residents in the seven major economic regions of China in 2020. To demonstrate the changing trends, this study analyses the dynamic evolution process and regional disparities in the common prosperity of rural areas and residents from 2011 to 2020. Using spatial econometric analyses, this study explores the overall clustering trends of the common prosperity of rural areas and residents in seven major economic regions in China. The results show that the overall level of common prosperity of rural areas and residents is rising at the national level; however, marked differences between provinces remain. Inequality between rural Chinese areas and rural residents is more acute in less economically developed regions. The problem is shifting from interregional to intraregional inequality, with obvious spatial differences. There is a clear positive spatial autocorrelation among most provinces in the seven economic regions and a significant spatial spillover effect in the Yangtze River Delta region.
Extracellular phase separation mediates storage and release of thyroglobulin in the thyroid follicular lumen
Authors: Knowles Tuomas , Yao Yihan , Erkamp Nadia , Sneideris Tomas , Yang Xiqiao , Scrutton Rob , Schneider Matthias , Fischer Charlotte , Schoenmakers Erik , Schoenmakers Nadia
Published: November 2024

Thyroid hormones are produced by the thyroid gland and are essential for regulating metabolism, growth and development. Maintenance of circulating thyroid hormone levels within an appropriate range is thus a prerequisite for health. In vivo, this objective is, at least in part, facilitated through an extracellular storage depot of thyroglobulin, the glycoprotein precursor for thyroid hormones, in the thyroid follicular lumen. The molecular basis for how soluble thyroglobulin molecules form such dense depot assemblies remains elusive. Here, we describe in vitro biophysical analysis of thyroglobulin phase behaviour, suggesting that thyroglobulin is prone to undergoing ionic strength-dependent phase separation, leading to the formation of liquid-like condensates. Fluorescence photobleaching measurements further show that these condensates age as a function of time to form reversible gel-like high density storage depots of thyroglobulin. Immunofluorescence experiments on mouse and human thyroid follicles ex vivo reveal that spherical globules of Tg protein dense phase are present in the follicular lumen, consistent with the idea that Tg undergoes phase separation. These findings reveal a molecular mechanism for the last-come-first-served process of thyroglobulin storage and release, suggesting a role for extracellular phase separation in thyroid hormone homeostasis by providing organizational and architectural specificity without requiring membrane-mediated confinement.
Exploring the Impact of CO2 Sequestration on Plastic Properties, Mechanical Performance, and Microstructure of Concrete
Authors: Pereira Clinton , Gupta Rishi
Published: November 2024

In view of global warming, carbon sequestration techniques are being employed across the globe to minimize the damaging impact of greenhouse gases on the environment. Findings of ongoing research have shown that adding CO2 during the mixing or curing stage of concrete enhances its mechanical properties. The purpose of this study is to examine the effect of CO2 addition during the mixing stage on the initial hydration and mechanical properties of concrete. Various CO₂ dosages, ranging from 0.1–1%, were injected during mixing to analyze fresh and hardened properties of concrete, and the test results were compared with the control mix. CO2 primarily reacts with calcium hydroxide in concrete to form calcium carbonate, thereby densifying its microstructure and improving its compressive strength by 10–20%. Thermal Pyrolysis tests, microscopy and infrared spectroscopy analysis indicated the presence of CaCO₃, thereby confirming the carbonation process. However, CO2 dosages above 0.5% by weight of cement resulted in a drop in the workability of fresh concrete, which was rectified by an additional dose of superplasticizer. The present research attempts to create a simplified CO2 sequestration process in concrete, develop a predictive model to estimate the compressive strength and use basic characterization techniques to identify the mineralization process. Findings from this research will provide simplified solutions to the construction industry that plans to implement CO2 sequestration in concrete.
Structural Dynamic Response of Simply Supported Beam Bridge of High-Speed Railway Based on Time-Dependency Deterioration of Concrete
Authors: Jia Baoxin , Xie Haiyang , Zhou Zhiyang , Yuan Wenya
Published: November 2024

To investigate the dynamic characteristics of simply-supported beam bridges in high-speed railways under long-term deterioration, the deterioration law of concrete strength, considering the combined effects of carbonation and freeze-thaw cycles, is analyzed based on time-varying concrete strength theory. The accuracy of the finite element model is validated by measuring and comparing the vibration signals of a two-lane simply-supported beam bridge on the Beijing-Shenyang high-speed railway. Subsequently, the frequency variability of mid-span box girder vibration signals and vibration energy is analyzed using local maximum synchrosqueezing transform, and the multifractal characteristics of the box girder vibration signals are further examined. The results indicate that vertical acceleration of the box girder and the top of the pier increased by 31.2% and 67.6%, respectively, as deterioration intensified. Additionally, the vibration frequency of the box girder decreased from 28 Hz to 25 Hz, suggesting a marked decline in structural stiffness. Simultaneously, the energy of the self-oscillating frequency near 8 Hz dispersed progressively over time. The width (Δα) of the multifractal spectrum increases gradually, reflecting more pronounced multifractal characteristics, while the waveform of the box girder vibration signals shifts from small to large wave peaks. These findings provide valuable insights for performance evaluation, safety monitoring, and maintenance of simply-supported beam bridges.
Synergistic Photocatalytic Remediation Using Fe 2 O 3 /BiVO 4 Nanocomposites: A Sustainable Solution
Authors: Chomkitichai Weerasak , Ubolsook Putthadee , Jansanthea Pongthep
Published: November 2024

This study explores the synthesis, characterization, and photocatalytic efficiency of Fe₂O₃/BiVO₄ nanocomposites for sustainable environmental remediation. Fe₂O₃ and BiVO₄, both semiconductor materials, exhibit complementary properties, making them promising candidates for synergistic photocatalysis. The nanocomposites were synthesized by varying the Fe ratio using a hydrothermal method followed by calcination. Several techniques, including X-ray diffraction (XRD), scanning electron microscopy (SEM), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDS), Brunauer-Emmett-Teller (BET) surface area analysis, UV-visible diffuse reflectance spectroscopy (UV-DRS), and photoluminescence (PL) analysis, were employed for characterization. XRD confirmed the rhombohedral structure of Fe₂O₃ and the monoclinic structure of BiVO₄. SEM and TEM images revealed uniform particle dispersion, with ~ 500 nm BiVO₄ particles surrounded by ~ 50 nm Fe₂O₃ aggregates. BET analysis showed that the surface area increased with Fe content. UV-DRS demonstrated visible light absorption with bandgap energies from 2.27 to 2.47 eV, suitable for photocatalytic applications. PL analysis indicated efficient charge separation due to reduced photoluminescence. Photocatalytic degradation of methylene blue (MB) revealed that the 2Fe/8Bi nanocomposite achieved the highest degradation efficiency (98.74%) with a rate constant of 0.0270 min⁻¹, outperforming individual Fe₂O₃ and BiVO₄. These results demonstrate the potential of Fe₂O₃/BiVO₄ nanocomposites as sustainable photocatalysts for environmental remediation, with promising prospects for addressing environmental challenges.
Development and Validation of a Prediction Model for Coronary Artery Disease in Chest Pain Patients: A Real-World Multicenter Study Based on Machine Learning
Authors: He Songtao , Jian Jie , Liu Gaiqin , Huang Yuxuan , Chen Longcong
Published: November 2024

Coronary artery disease (CAD) is a prevalent condition among chest pain patients, and accurate prediction of the disease is crucial to ensure timely interventions and improve patient outcomes. We aim to elaborate a prediction model for CAD in chest pain patients using machine learning approaches. A retrospective analysis was performed using electronic health records of patients who presented with chest pain at seven hospitals. A total of 8474 patients were included in the study, where 63.25% were diagnosed with CAD. The data included demographic information, medical history, and laboratory results. Machine learning algorithms, including Random Forest, CatBoost, XGBoosting, Gradient Boosting, Light Gradient, AdaBoost, Ridge Classifier, Linear Discriminant, Logistic Regression, Decision Tree, SVM, Quadratic Discriminant, K Neighbors, Naive Bayes, and Dummy Classifier were trained and evaluated to predict the presence of CAD.The prediction model achieved an overall accuracy of 0.766 in identifying CAD in chest pain patients. The sensitivity and precision were 0.938 and 0.746, respectively. Important predictors for CAD included age, pulse rate, monocyte, and red cell distribution width SD. The eXtreme Gradient Boosting showed the best performance (area under the receiver operating characteristics, AUROC, 0.820, and 95% CI, 0.801–0.839) Additionally, the model demonstrated robust performance in the validation group. This study successfully developed and validated a prediction model for CAD in chest pain patients using machine learning techniques. The model exhibited good predictive ability and could aid in the early identification of CAD in clinical practice, potentially leading to appropriate interventions and improved patient outcomes.
Subareolar Breast abscess in Males:Brief Communication
Authors: Wani Imtiaz , Wani Rauf , Wani Munir
Published: November 2024

Introduction
Subareolar breast abscess is extremely rare in males .Only a few cases of male breast abscess are reported in the literature till date. The clinical presentation of male breast include pain, periareolar swelling, tenderness and rarely nipple discharge.
Aim
To study occurrence of subareolar abscess in males
Patient and Methods
A retrospective study of 11 patients from April 2014 –July 2024 is reported who presented with subareolar breast abscess. Four had uncomplicated abscess and one has underlying carcinoma breast. Incision drainage was done in 7 cases and one who has underlying carcinoma was managed by local toilet and antibiotics for abscess whereas rest two had needle aspiration for pus and one has conservative treatment by antibiotics.
Conclusion
Subareolar breast abscess is rare in males. Incision and drainage is treatment of choice in an uncomplicated cases.
Loss of helpful bacteria within Tribolium castaneum that aid in coping with UVA and UVB stress
Authors: Wang Fei-Feng , Li Min-Er , Dong Lu-Lu , Liu Zhao-Kang , Xia Yu-Die , Yu Lin , Qiu Bao-Li , Sang Wen
Published: November 2024

Tribolium castaneum (Herbst), which resides in shaded areas avoiding daylight, has developed various adaptation strategies to cope with ultraviolet (UV) stress. In this study, we utilized 16S rRNA amplicon sequencing to assess the diversity of the bacterial communities within T. castaneum following exposure to ultraviolet-A and ultraviolet-B for different durations, and to elucidate the role of microbiome in host response to UV stress. This study revealed that UV irradiation affected the relative abundance of bacterial community within T. castaneum, rather than its species richness. The significant differences were observed in the relative abundance of Proteobacteria and Cyanobacteria, among the comparison of UV irradiation groups at phylum level. Most genes coded by bacteria were annotated on membrane transport, replication and repair, amino acid metabolism, energy metabolism and carbohydrate metabolism with reference to Kyoto Encyclopedia of Genes and Genomes database. However, the significant differences identified in this study were limited, making it challenging to establish a clear relationship between UV irradiation and the bacteria within T. castaneum larvae. Consequently, we propose the viewpoint that the role of bacteria in contributing T. castaneum against UV stress may have been diminished during their development due to the low-UV rearing conditions.
Application of 3-dimensional reconstruction via modified pulmonary artery computed tomography angiography in anatomic pulmonary segmentectomy
Authors: Min Weiwei , zhang jianbin , Zhu Yilv , Jin Lili
Published: November 2024

Background
This retrospective study aimed to summarize the application of 3-dimensional(3D) reconstruction via modified pulmonary artery computed tomography angiography(CTA), as well as to compare the surgical outcomes of 3D versus high resolution CT(HRCT) in anatomic pulmonary segmentectomy(APS).
Methods
A total of 93 patients who underwent thoracoscopic APS were enrolled in the study. They were divided into 3D group (n = 30) and HRCT group (n = 63), and than matched at 1:1 ratio using the propensity score matching (PSM) method. Clinical characteristics, surgical status, and postoperative recovery were compared between two groups, additionally, variations of segmental structures were summarized.
Results
60 cases were matched by PSM with 30 cases in each group. There were no significant differences between two groups in clinical characteristics, intraoperative blood loss and postoperative recovery (including total chest drainage, length of postoperative hospital stay)(P > 0.05 for all). 8(26.7%) patients in 3D group manifesting unique variations of segmental structures underwent anatomical segmentectomy accurately. Despite the 3D group exhibited higher anatomic variations compared to the HRCT group, it demonstrated shorter operation times and lower incidence of pulmonary infection. (P < 0.05 for all).
Conclusion
Preoperative 3D reconstruction has advantages in APS, particularly for patients with complex anatomic variations. Reconstruction via modified pulmonary artery CTA is also feasible for preoperative planning and intraoperative navigation in thoracoscopic APS.
Implementation of a cardiovascular toolkit in primary care increased women Veterans’ engagement in behavior change programs: results from a non-randomized stepped wedge trial
Authors: Farmer Melissa M , Hamilton Alison B , Finley Erin P , Lee Martin , Chanfreau Catherine , Than Clarie , Brunner Julian , Schweizer C. Amanda , Huynh Alexis K , Moin Tannaz , Bean-Mayberry Bevanne
Published: November 2024

Background
Cardiovascular (CV) disease is the leading cause of death among U.S. women, yet women have a limited understanding of their CV-related morbidity and mortality risks. Provider-, system-, and patient-level barriers point to a need for multi-level evidence-based strategies to facilitate CV risk reduction. Guided by the Replicating Effective Programs framework and complexity theory, we implemented a CV Toolkit in primary care clinics for women Veterans. The objective was to evaluate the effect of implementation of CV toolkit on participation in behavior change programs that target CV risk reduction.
Methods
In partnership with the Veterans Health Administration (VA) Office of Women’s Health and National Center for Health Promotion and Disease Prevention, we developed and implemented a CV Toolkit at five geographically diverse VA sites between March 2017-March 2020. Using a non-randomized stepped wedge design, we evaluated the effect of the implementation of toolkit on participation in the VA MOVE! weight management program, and on participation in health promotion and disease prevention (HPDP) programs (coaching, facilitated groups, etc.) and/or complementary integrative health (CIH) programs (yoga, meditation, etc.). We utilized a three-level (patient, site, time) non-linear fixed effect model with stratification by age (65 and older versus younger). Patient participation, utilization, and demographics were extracted from VA administrative data for all women with at least one primary care visit at a participating site from December 2016-March 2020 (n = 6009).
Results
Women were on average 45 years old; 38% were white, 31% Black, 17% Hispanic; and over a third had CV risk factors and/or mental health diagnoses. For women 65 years and older (n = 540), active toolkit implementation resulted in increased odds of MOVE! participation (OR = 1.09; 95% CI:1.030–1.152) compared to when the toolkit was not active either within or between sites. Women younger than 65 (n = 5469) had increased odds of using HPDP/CIH programs during active toolkit implementation (OR = 1.01; 95% CI:1.002–1.022).
Conclusions
Active implementation of the CV Toolkit intervention was significantly associated with increasing participation in behavior change programs. Variation in program participation by age suggests that the diversity of behavior change programs available to women Veterans may facilitate participation across the lifespan.
Trial registration:
Clinical Trials.gov, NCT02991534. Registered 12-09-2016, https://clinicaltrials.gov/study/NCT02991534?cond=NCT02991534&rank=1