bluuebunny/crossref_metadata_2025 huggingface dataset:
Do the Activity Indices Used in Axial Spondyloarthritis Capture the Relationships Between Obesity, Smoking and Disease Activity in the Same Way?
Authors: Queiro Rubén , Alonso-Castro Sara , Braña Ignacio , Loredo Marta , Pardo Estefanía , Burger Stefanie , Chiminazzo Valentina , Alperi Mercedes
Published: November 2024

Background/Objectives: Obesity and smoking have been related to increased disease activity in axial spondyloarthritis (axSpA), but these associations might vary depending on the composite index chosen to assess disease activity. We aimed to check this possibility. Methods: Three hundred and thirty consecutive patients were recruited from the monographic axSpA unit of a university center. To assess disease activity, BASDAI and ASDAS-CRP measurements were collected. The factors associated with the different disease activity thresholds of these instruments were analyzed using univariate and multivariate logistic regression models. Results: This study included 127 women and 203 men, with a mean age of 47.6 (SD 12.9) years, median disease duration of 8 years [IQR: 4–16], and 63% on biologic therapies. Most patients met the therapeutic goals, with a BASDAI < 4 in 187 (56.7%) and ASDAS inactive/low category in 182 (55.2%). Being male was associated with BASDAI remission (OR 2.63), but smoking reduced this likelihood (OR 0.28). Similar findings were found for ASDAS inactive disease (male: OR 2.09; smoking: OR 0.39). The variables associated with BASDAI ≥ 4 in the multivariate logistic model were the male gender (OR 0.36), age (OR 1.02), smoking (OR 2.39), and obesity (OR 2.94), whereas those associated with active/very active ASDAS categories were the male gender (OR 0.49), age (OR 1.02), and smoking (OR 2.34). However, obesity was not associated with these higher ASDAS categories (p = 0.183). Conclusions: While the association between smoking and increased disease activity was consistent across all composite activity indices, the obesity–activity relationship was only apparent through the BASDAI.
Catheter Ablation for Ventricular Tachycardias: Current Status and Future Perspectives
Authors: Kataoka Naoya , Imamura Teruhiko
Published: November 2024

Catheter ablation for ventricular tachycardia (VT) in patients with systolic heart failure remains a critical yet challenging area of non-pharmacological therapy. Despite positive outcomes in atrial fibrillation, evidence for the efficacy of VT ablation in reducing cardiac mortality is inconclusive due to the absence of standardized ablation strategies. The primary challenges include difficulties in identifying suitable ablation targets and their deep locations within myocardial tissue. Current techniques, such as voltage mapping, provide valuable insights; however, they are limited by the presence of numerous bystander areas and the occurrence of incomplete transmural scarring. Recent advancements in functional substrate mapping have focused on identifying critical isthmuses without requiring hemodynamic stabilization during VT, thereby shifting the emphasis to the analysis of potentials during baseline rhythm. While methods like isochronal late activation mapping have improved target identification, they primarily address conduction abnormalities without adequately considering repolarization heterogeneity. This review highlights emerging technologies that utilize unipolar potentials to assess repolarization heterogeneities and identify VT isthmuses. Furthermore, novel ablation sources such as pulsed-field ablation, bipolar ablation, and ultra-low temperature cryoablation are being explored to create deeper and more durable lesions, addressing the limitations of traditional radiofrequency ablation. These advancements aim to reduce VT recurrence and improve overall treatment efficacy. Ultimately, understanding these innovative strategies is expected to optimize procedural outcomes and significantly enhance the management of patients with scar-related VT.
Curvature of Posterior Pole in Eyes with Retinitis Pigmentosa
Authors: Kakisu Masato , Miura Gen , Nagai Tatsuya , Akiba Ryutaro , Baba Takayuki
Published: November 2024

Background/Objectives: This study aimed to determine whether there is a significant change in eyeball curvature in eyes with retinitis pigmentosa (RP). Methods: The medical records of 35 eyes of 18 patients with RP and age- and axial-length-matched controls were reviewed. The curvature of the posterior pole was determined by approximating a second-order polynomial equation based on the optical coherence tomography (OCT) images. Associations among eyeball curvature, refractive error, and axial length were investigated. Results: The average age of patients with RP was 65.1 ± 13.8 years, and the average axial length of the eye was 23.90 mm. The curvature of the posterior eyeball was steeper in eyes with RP (p = 0.020), and the choroid was thinner in eyes with RP (p < 0.01). The curvature of eyes with RP significantly correlated with refractive error (p = 0.006, r = −0.46) and axial length (p = 0.004, r = −0.48). Conclusions: The significant correlation between eyeball curvature and axial length suggests that myopia affects eyeball shape even in eyes with RP. However, the curvature remained steep in the eyes with RP after matching for age and axial length. A thinner choroid was observed in eyes with RP and may play a role in the steeper posterior eyeball.
Structural Behavior of Full-Depth Deck Panels Having Developed Closure Strips Reinforced with GFRP Bars and Filled with UHPFRC
Authors: Sayed Ahmed Mahmoud , Sennah Khaled , Afefy Hamdy M.
Published: November 2024

The adoption of prefabricated elements and systems (PBES) in accelerating bridge construction (ABC) and rapidly replacing aging infrastructure has attracted considerable attention from bridge authorities. These prefabricated components facilitate quick assembly, which diminishes the environmental footprint at the construction site, alleviates delays and lane closures, reduces disruption for the traveling public, and ultimately conserves both time and taxpayer resources. The current paper explores the structural behavior of a reinforced concrete (RC) precast full-depth deck panel (FDDP) having 175 mm projected glass-fiber-reinforced polymer (GFRP) bars embedded into a 200 mm wide closure strip filled with ultra-high-performance fiber-reinforced concrete (UHPFRC). Three joint details for moment-resisting connections (MRCs), named the angle joint, C-joint, and zigzag joint, were constructed and loaded to collapse. The controlled slabs and mid-span-connected precast FDDPs were statically loaded to collapse under concentric or eccentric wheel loading. The moment capacity of the controlled slab reinforced with GFRP bars compared with the concrete slab reinforced with steel reinforcing bars was less than 15% for the same reinforcement ratio. The precast FDDPs showed very similar results to those of the controlled slab reinforced with GFRP bars. The RC slab reinforced by steel reinforcing bars failed in the flexural mode, while the slab reinforced by GFRP bars failed in flexural-shear one.
Regional Body Composition and Strength, Not Total Body Composition, Are Determinants of Performance in Climbers
Authors: Carrasco Fernando , Arias-Tellez Maria Jose , Solar-Altamirano Ignacio , Inostroza Jorge , Carrasco Gabriela
Published: November 2024

Objective: To compare the body composition of Chilean climbers of different performance levels and to determine the relation between the forearm and upper-trunk lean mass and the handgrip and upper-body traction strength, respectively. Methods: A cross-sectional study was carried out on thirty Chilean male adult climbers (26.1 ± 4.9 y.): nine of intermediate level (L1), eleven advanced (L2), and ten elite (L3). Through dual-energy X-Ray absorptiometry (DXA; Lunar Prodigy®), fat mass percentage (FM%), total lean mass (LM), forearm lean mass (FLM), and upper-trunk lean mass (UTLM) were measured. Total muscle mass (TMM) was also estimated. Handgrip strength (HGS) was measured with a Jamar® dynamometer. Maximum upper-body traction strength (UBTS) was evaluated with a standardized movement. The level of climbing was assessed according to IRCRA rules. Results: No differences in FM%, total LM, UTLM, or TMM between the groups were found. Left and assistant FLM were significantly higher in L3 (p = 0.047 and 0.041, respectively). HGS absolute, relative, and adjusted by FLM were not different between groups. FLM was associated with HGS in all segments (p ≤ 0.001). UBTS absolute values, and as adjusted by TMM, were significantly higher in L3 (p = 0.047 and p = 0.049, respectively). Conclusions: Left and non-dominant forearm lean mass were significantly higher in elite climbers. Handgrip strength was not significantly higher in elite climbers; however, the upper-body traction strength was significantly higher in elite climbers, independent of total or regional muscle mass.
Study of Physiological Adaptations in Vertical Kilometer Runners: Focus on Cardiorespiratory and Local Muscle Demands
Authors: Bascuas Pablo Jesús , Gutiérrez Héctor , Piedrafita Eduardo , Bataller-Cervero Ana Vanessa , Berzosa César
Published: November 2024

Background: Research into key performance factors in trail running, particularly in vertical kilometer (VK) races, is crucial for effective training and periodization. However, recent studies on metabolic and cardiorespiratory responses during VK races, especially using field tests, are limited. Objectives: Therefore, the aim of this study is to evaluate the metabolic and cardiorespiratory responses during a VK field test, identifying differences based on sex and performance level, as well as key performance factors and their deterioration due to fatigue. Fifteen trained trail runners (ten males and five females, 19 to 38 years old) perform a VK race. Methods: The global physiological response is evaluated using the portable gas analyzer Cosmed K5 and the local response using near-infrared spectroscopy technology. Results: In gender comparisons, the ANCOVA test shows significant differences (p < 0.05) in the ventilation, tidal volume, expiratory time-to-inspiratory time ratio, inspiratory flow rate, end-tidal CO2 partial pressure, heart rate, oxygen pulse, and total hemoglobin. Additionally, the performance comparison reveals significant differences in the variables’ velocity, oxygen consumption, carbon dioxide production, ventilation, dead space-to-tidal volume ratio, total time of the breathing cycle, expiratory time-to-inspiratory time ratio, inspiratory duty cycle, expiratory fractions of CO2, quadriceps saturation index, and VE/VCO2 ratio. Finally, the correlation analysis shows oxygen consumption (r = −0.80 mean; r = −0.72 peak), carbon dioxide production (r = −0.91 mean; r = −0.75 peak), expiratory time-to-inspiratory time ratio (r = 0.68 peak), ventilation (r = −0.58 mean), and quadriceps saturation index (r = 0.54 mean; r = −0.76 coefficient of variation) as the key performance factors in the VK race. Conclusions: Overall, the physiological analysis indicates the importance of local muscular adaptations and respiratory system capacity in this type of short-duration race.
Clinical Benefits of Sustained Oral Nirmatrelvir/Ritonavir Use for the Outpatient Treatment of COVID-19: Findings from the Taiwanese Health Authority Perspective Using a Decision Tree Modeling Approach
Authors: Sussman Matthew , Benner Jennifer , Mugwagwa Tendai , Lee Jackie , Hung Sheng-Tzu , Yang Ya-Min , Chen Yixi
Published: November 2024

Despite the observed clinical benefits of nirmatrelvir/ritonavir (NMV/r), it is uncertain whether Taiwan will continue covering NMV/r for high-risk individuals with mild-to-moderate coronavirus disease 2019 (COVID-19). This analysis assessed the impact of sustained utilization of NMV/r on COVID-19-associated healthcare resource utilization (HCRU) and mortality from the Taiwanese health authority perspective (THAP). A decision tree model estimated the incremental number of clinical events associated with NMV/r utilization over a 30-day period. Model results compared (1) a base case using current rates of NMV/r from the THAP, and (2) a hypothetical scenario assuming the current supply of NMV/r is not extended in Taiwan. NMV/r utilization rates included 80% and 0% in the base case and hypothetical scenario, respectively. Outcomes included the number of hospitalizations involving a general ward (GW) stay, intensive care unit (ICU) stay, and mechanical ventilation (MV) use, as well as the number of bed days, symptom days, and hospitalization deaths. Based on epidemiologic data, 150,255 patients with COVID-19 were eligible for treatment from the THAP. In the hypothetical scenario, HCRU increased by 175% compared to the base case, including increases in hospitalizations involving GW, ICU, and MV use (differences: 2067; 623; 591, respectively), bed days (difference: 51,521), symptom days (difference: 51,714), and deaths (difference: 480). Findings indicate that sustained utilization of NMV/r from the THAP reduces the clinical burden of mild-to-moderate COVID-19 through the reduced incidence of COVID-19-related HCRU and deaths.
Improving the Quality of Reshaped EoL Components by Means of Accurate Metamodels and Evolutionary Algorithms
Authors: Piccininni Antonio , Cusanno Angela , Palumbo Gianfranco , Ingarao Giuseppe , Fratini Livan
Published: November 2024

The reshaping of End-of-Life (EoL) components by means of the sheet metal forming process has been considered largely attractive, even from the social and economic point of view. At the same time, EoL parts can often be characterized by non-uniform thicknesses or alternation of work-hardened/undeformed zones as the result of the manufacturing process. Such heterogeneity can hinder a proper reshaping of the EoL part, and residual marks on the reformed blanks can still be present at the end of the reshaping step. In a previous analysis, the authors evaluated the effectiveness of reshaping a blank with a deep-drawn feature by means of the Sheet Hydroforming (SHF) process: it was demonstrated that residual marks were still present if the deep-drawn feature was located in a region not enough strained during the reshaping step. Starting from this condition and adopting a numerical approach, additional investigations were carried out, changing the profile of the load applied by the blank holder and the maximum oil pressure. Numerical results were collected in terms of overall strain severity and residual height of the residual marks from the deep-drawn feature at the end of the reshaping step. Data were then fitted by accurate Response Surfaces trained by means of interpolant Radial Basis Functions and anisotropic Kriging algorithms, subsequently used to carry out a virtual optimization managed by multi-objective evolutionary algorithms (MOGA-II and NSGA-II). Optimization results, subsequently validated via experimental trials, provided the optimal working conditions to achieve a remarkable reduction of the marks from the deep-drawn feature without the occurrence of rupture.
Managing Residual Heat Effects in Femtosecond Laser Material Processing by Pulse-on-Demand Operation
Authors: Petelin Jaka , Marš Matevž , Mur Jaka , Petkovšek Rok
Published: November 2024

Femtosecond laser processing combines highly accurate structuring with low residual heating of materials, low thermal damage, and nonlinear absorption processes, making it suitable for the machining of transparent brittle materials. However, with high average powers and laser pulse repetition rates, residual heating becomes relevant. Here, we present a study of the femtosecond laser pulse-on-demand operation regime, combined with regular scanners, aiming to improve throughput and quality of processing regardless of the scanner’s capabilities. We developed two methods to define the needed pulse-on-demand trigger sequences that compensate for the initial accelerating scanner movements. The effects of pulse-on-demand operation were studied in detail using direct process monitoring with a fast thermal camera and indirect process monitoring with optical and topographical surface imaging of final structures, both showing clear advantages of pulse-on-demand operation in precision, thermal effects, and structure shape control. The ability to compensate for irregular scanner movement is the basis for simplified, cheaper, and faster femtosecond laser processing of brittle and heat-susceptible materials.
An ADCP Attitude Dynamic Errors Correction Method Based on Angular Velocity Tensor and Radius Vector Estimation
Authors: Sun Zhaowen , Yao Shuai , Gao Ning , Zhang Ke
Published: November 2024

An acoustic Doppler current profiler (ADCP) installed on a platform produces rotational tangential velocity as a result of variations in the platform’s attitude, with both the tangential velocity and radial orientation varying between each pulse’s transmission and reception by the transducer. These factors introduce errors into the measurements of vessel velocity and flow velocity. In this study, we address the errors induced by dynamic factors related to variations in attitude and propose an ADCP attitude dynamic error correction method based on angular velocity tensor and radius vector estimation. This method utilizes a low-sampling-rate inclinometer and compass data and estimates the angular velocity tensor based on a physical model of vessel motion combined with nonlinear least-squares estimation. The angular velocity tensor is then used to estimate the transducers’ radius vectors. Finally, the radius vectors are employed to correct the instantaneous tangential velocity within the measured velocities of the vessel and flow. To verify the effectiveness of the proposed method, field tests were conducted in a water pool. The results demonstrate that the proposed method surpasses the attitude static correction approach. In comparison with the ASC method, the average relative error in vessel velocity during free-swaying movement decreased by 20.94%, while the relative standard deviation of the error was reduced by 17.38%.
A Comparison of the Capture Width and Interaction Factors of WEC Arrays That Are Co-Located with Semi-Submersible-, Spar- and Barge-Supported Floating Offshore Wind Turbines
Authors: Tay Zhi Yung , Htoo Nyan Lin , Konovessis Dimitrios
Published: November 2024

This research paper explores an approach to enhancing the economic viability of the heaving wave energy converters (WECs) of both cylinder-shaped and torus-shaped devices, by integrating them with four established, floating offshore wind turbines (FOWTs). Specifically, the approach focused on the wave power performance matrix. This integration of WECs and FOWTs not only offers the potential for shared construction and maintenance costs but also presents synergistic advantages in terms of power generation and platform stability. The study began by conducting a comprehensive review of the current State-of-the-Art in co-locating different types of WECs with various foundation platforms for FOWTs, taking into consideration the semi-submersible, spar and barge platforms commonly employed in the offshore wind industry. The research took a unified approach to investigate more and new WEC arrays, totaling 20 configurations across four distinct FOWTs. The scope of this study’s assumption primarily focused on the hydrodynamic wave power performance matrix, without the inclusion of aerodynamic loads. It then compared their outcomes to determine which array demonstrated superior wave energy under the key metrics of total absorbed power, capture width, and interaction factor. Additionally, the investigation could serve to reinforce the ongoing research and development efforts in the allocation of renewable energy resources.
Comparative Study of Different Alternative Fuel Options for Shipowners Based on Carbon Intensity Index Model Under the Background of Green Shipping Development
Authors: Zhang Jin , Zhang Zhonghao , Liu Ding
Published: November 2024

The International Maritime Organization (IMO)’s annual operational carbon intensity index (CII) rating requires that from 1 January 2023, all applicable ships meet both technical and operational energy efficiency requirements. In this paper, we conduct a comparative study of different alternative fuel options based on a CII model from the perspective of shipowners. The advantages and disadvantages of alternative fuel options, such as liquefied natural gas (LNG), methanol, ammonia, and hydrogen, are presented. A numerical example using data from three China Ocean Shipping (Group) shipping lines is analyzed. It was found that the overall attained CII of different ship types showed a decreasing trend with the increase of the ship’s deadweight tonnage. A larger ship size choice can obtain better carbon emission reduction for the carbon emission reduction investment program using alternative fuels. The recommended options of using LNG fuel and zero-carbon fuel (ammonia and hydrogen) on Route 1 and Route 3 during the study period were analyzed for the shipowners. Carbon reduction scenarios using low-carbon fuels (LNG and methanol) and zero-carbon fuels (ammonia and hydrogen) on Route 2 are in line with IMO requirements for CII.
Level of Service Evaluation Method for Waterway Intersections
Authors: Liu Yihua , Guo Xin , Lin Fei , Liu Nian , Ni Daiheng
Published: November 2024

Waterway intersections pose significant risks for vessel navigation due to the complexities of operational conditions in these areas. The lack of clear collision avoidance rules, combined with ineffective communication, exacerbates these dangers. To address this issue, transportation authorities will typically employ flow organization strategies to optimize operations at these intersections. However, effective methods for traffic management, both before and after implementation, are still lacking. This paper proposes a methodology to determine the level of service (LOS) needed for waterway intersections by using the degree of conflict during vessel navigation as a performance measure, while also considering the unique characteristics of vessel encounters in these areas. The methodology was applied to analyze the Yuxingnao waterway, and the results demonstrate its effectiveness in assessing operational conditions and providing a clear classification of service levels over specific time periods. Consequently, this methodology not only enables transportation authorities to evaluate the effectiveness of traffic management strategies, such as route planning and traffic organization, but also helps predict the impact of potential improvement countermeasures.
Quantitative Monitoring of Cyclic Glycine–Proline in Marine Mangrove-Derived Fungal Metabolites
Authors: Lin Jing , Qin Fei , Lin Zeye , Lin Weijian , You Minxin , Xu Li , Hu Lei , Chen Yung-Husan
Published: November 2024

This study developed and validated a robust UPLC-MS/MS method for quantifying cyclic glycine–proline (cGP) in mangrove-derived Penicillium and Aspergillus strains. The method demonstrated excellent linearity, precision, and recovery, with detection limits as low as 4.8 ng/mL. Penicillium pedernalense extract achieved a cGP content of 67.45 ± 1.11 ng/mL, with a corresponding fermentation yield of 29.31 ± 0.61 mg/L. This surpassed Penicillium steckii, which reached a content of 31.71 ± 0.31 ng/mL, with a yield of 8.51 ± 0.15 mg/L. This quantitative approach for metabolite analysis provides a viable method for screening these fungal strains, highlighting their potential for sustainable production of cyclic glycine–proline (cGP).
An Algerian Soil-Living Streptomyces alboflavus Strain as Source of Antifungal Compounds for the Management of the Pea Pathogen Fusarium oxysporum f. sp. pisi
Authors: Masi Marco , Nedjar Dorsaf , Bani Moustafa , Staiano Ivana , Salvatore Maria Michela , Khenaka Karima , Castaldi Stefany , Zorrilla Jesus Garcia , Andolfi Anna , Isticato Rachele , Cimmino Alessio
Published: November 2024

Fusarium wilt caused by Fusarium oxysporum f. sp. pisi (Fop) poses significant threats to pea cultivation worldwide. Controlling this disease is mainly achieved through the integration of various disease management procedures, among which biological control has proven to be a safe and effective approach. This study aims to extract and identify antifungal secondary metabolites from Streptomyces alboflavus KRO3 strain and assess their effectiveness in inhibiting the in vitro growth of Fop. This bacterial strain exerts in vitro antagonistic activity against Fop, achieving highly significant inhibition over one week. The ethyl acetate extract, obtained from its ISP2 agar medium culture, also exhibited strong antifungal activity, maintaining an inhibition rate of approximately 90% at concentrations up to 250 µg/plug compared to the control. Thus, the organic extract has been fractionated using chromatographic techniques and its bioguided purification allowed us to isolate the main bioactive compound. This latter was identified as metacycloprodigiosin using nuclear magnetic resonance (NMR) spectroscopy, electrospray ionization mass spectrometry (ESI-MS), and specific optical rotation data. Metacycloprodigiosin demonstrates dose-dependent inhibitory activity against the phytopathogen with an effective concentration of 125 µg/plug. The other secondary metabolites present in the ethyl acetate extract were also identified by gas chromatography–mass spectrometry (GC-MS) and nuclear magnetic resonance (NMR). This study highlighted the potential of S. alboflavus KRO3 strain and its antimicrobial compounds for the management of the pea pathogen Fusarium oxysporum f. sp. pisi.
The Unusual Presentation of Non-ST Elevation Myocardial Infarction Following Acute Carbon Monoxide Poisoning in an Elderly Female: A Case Report
Authors: Al-Busaidi Salim , Al Shandoudi Leena , Al-Ghafri Manal , Shoaib Muhammad
Published: November 2024

Carbon monoxide (CO) poisoning is a leading cause of poisoning-related deaths, particularly affecting organs with high oxygen demands such as the heart and brain. Cardiac complications, including non-ST elevation myocardial infarction (NSTEMI), can occur due to CO poisoning but are not frequently reported in the elderly. We present the case of an 82-year-old female with a medical history of diabetes, hypertension, dyslipidemia, and previous ischemic heart disease. She was brought to the emergency department after being found drowsy in a closed room with a burning charcoal heater. The initial assessment revealed a carboxyhemoglobin level of 33.5%, which decreased to 9.3% after high-flow oxygen therapy and hyperbaric oxygen therapy (HBOT). Laboratory tests indicated elevated troponin levels, and an ECG showed asymmetrical T-wave inversion and ST depression. Despite the improvement in carboxyhemoglobin, the patient experienced persistent chest pain and rising troponin levels. She was treated with dual antiplatelet therapy and low molecular weight heparin as per acute coronary syndrome protocol, leading to a gradual improvement and a subsequent discharge in a stable condition. This case highlights the potential for CO poisoning to induce NSTEMI in elderly patients. A prompt diagnosis and appropriate management, including the use of HBOT, were crucial for the patient’s recovery.
Impact of Legacy Perfluorooctane Sulfonate (PFOS) and Perfluorooctanoate (PFOA) on GABA Receptor-Mediated Currents in Neuron-Like Neuroblastoma Cells: Insights into Neurotoxic Mechanisms and Health Implications
Authors: Lagostena Laura , Rotondo Davide , Gualandris Davide , Calisi Antonio , Lorusso Candida , Magnelli Valeria , Dondero Francesco
Published: November 2024

Perfluorooctane sulfonate (PFOS) and perfluorooctanoic acid (PFOA) are persistent environmental pollutants, raising concerns due to their widespread presence and disruptive biological effects. These compounds are highly stable, allowing them to bioaccumulate in the environment and living organisms, potentially impacting critical physiological functions such as hormonal balance, immune response, and increasing cancer risk. Despite regulatory restrictions, their pervasive nature necessitates further research into their potential effects on cellular and neuronal function. This study first evaluated the cytotoxic effects of PFOS and PFOA on S1 neuroblastoma cells; a dose-dependent reduction in cell viability was revealed for PFOS, while PFOA exhibited minimal toxicity until millimolar concentrations. We further investigated their potential to modulate GABAergic neurotransmission using patch-clamp electrophysiology. Both PFOS and PFOA caused a significant but reversible reduction in GABA receptor-mediated currents following one-minute pre-treatment. These findings suggest that PFOS and PFOA can interfere with both cellular viability and GABAergic signaling, providing critical insights into their functional impacts and highlighting the need for further investigation into the long-term consequences of PFAS exposure on nervous system health.
The Effects of Regulated Auditor Tenure on Opinion Shopping: Evidence from the Korean Market
Authors: Lee Beu , Gamble George , Noland Thomas , Zhao Yuping
Published: November 2024

We examine the impact of regulated auditor tenure on the shopping for favorable audit reports. We predict that these regulations may affect auditors’ willingness to acquiesce and clients’ incentives to engage in opinion shopping. We draw from the unique Korean setting where both mandatory audit firm retention and mandatory rotation were implemented for all public firms in a staggered manner. Based on hand-collected audit reports, we identify harmful language in explanatory paragraphs. We define favorable audit reports as those with unqualified opinions and without any harmful explanatory language. We find that opinion shopping for favorable audit reports appears to subside after mandatory retention but increases after mandatory rotation, with the positive impact of mandatory retention offset by the negative impact of mandatory rotation. We add to the literature by examining the impact of regulated auditor tenure on opinion shopping and highlighting the potential unintended consequences of these regulatory attempts.
The GARCH-EVT-Copula Approach to Investigating Dependence and Quantifying Risk in a Portfolio of Bitcoin and the South African Rand
Authors: Ndlovu Thabani , Chikobvu Delson
Published: November 2024

This study uses a hybrid model of the exponential generalised auto-regressive conditional heteroscedasticity (eGARCH)-extreme value theory (EVT)-Gumbel copula model to investigate the dependence structure between Bitcoin and the South African Rand, and quantify the portfolio risk of an equally weighted portfolio. The Gumbel copula, an extreme value copula, is preferred due to its versatile ability to capture various tail dependence structures. To model marginals, firstly, the eGARCH(1, 1) model is fitted to the growth rate data. Secondly, a mixture model featuring the generalised Pareto distribution (GPD) and the Gaussian kernel is fitted to the standardised residuals from an eGARCH(1, 1) model. The GPD is fitted to the tails while the Gaussian kernel is used in the central parts of the data set. The Gumbel copula parameter is estimated to be α=1.007, implying that the two currencies are independent. At 90%, 95%, and 99% levels of confidence, the portfolio’s diversification effects (DE) quantities using value at risk (VaR) and expected shortfall (ES) show that there is evidence of a reduction in losses (diversification benefits) in the portfolio compared to the risk of the simple sum of single assets. These results can be used by fund managers, risk practitioners, and investors to decide on diversification strategies that reduce their risk exposure.
Evolution of Green Finance: Mapping Its Role as a Catalyst for Economic Growth and Innovation
Authors: Marín-Rodríguez Nini Johana , González-Ruiz Juan David , Botero Sergio
Published: November 2024

This scientometric study analyzes the evolving landscape and outlook of green finance as a driver of economic innovation and growth, highlighting key trends and influential research within this critical field. A dataset of 371 publications was compiled from the Scopus and Web of Science databases and analyzed using VOSviewer, Bibliometrix, and Voyant tools to map the research landscape. By systematically reviewing the scientific literature, this research tracks the development of green finance’s role as a catalyst for economic innovation and growth, identifying trending topics, key studies, and major contributors through bibliometric and scientometric methods. The analysis reveals a growing interdisciplinary approach, integrating environmental, social, and political dimensions into green finance research. Keyword analysis identified three primary thematic clusters: (1) green finance and innovation, (2) economic growth, carbon neutrality, and fintech, and (3) renewable energy and urbanization. This study provides a comprehensive overview of the field and aims to guide future research while contributing to ongoing debates on the role of green finance in fostering economic innovation and sustainable growth.
Sustainable Soil Management in Alkaline Soils: The Role of Biochar and Organic Nitrogen in Enhancing Soil Fertility
Authors: Khan Mushtaq Ahmad , Basir Abdul , Shah Syed Tanveer , Rehman Monsif Ur , Hassan Mehmood ul , Zheng Hongbing , Basit Abdul , Székely Árpád , Jamal Aftab , Radicetti Emanuele , Dewir Yaser Hassan , Mancinelli Roberto
Published: November 2024

Biochar (BC) serves a vital function in sequestering carbon, improving nutrient cycles, and boosting overall soil quality. This research explored the enhancement of the chemical and physical properties of soil (alkaline) using nitrogen and biochar (from organic and inorganic sources) in a semi-arid climate during the autumn seasons of 2015–2016 and 2016–2017. The study involved applying biochar at various rates (0, 10, 20, and 30 t ha⁻1) and nitrogen at different levels (0, 90, 120, and 150 kg ha⁻1) using urea, poultry manure (PM), and farmyard manure (FYM) as nitrogen sources, which were applied to the field in a randomized complete block design with split-plot arrangement. The application of biochar at the highest rate (30 t ha⁻1) resulted in a significant increase of over 120% in soil organic matter (SOM), soil organic carbon (SOC), and soil moisture content (SMC). Additionally, it increased total soil nitrogen (STN) by 14.16% and mineral nitrogen (SMN) by 9.09%. In contrast, applying biochar at this rate reduced soil bulk density (SBD), pH, and electrical conductivity (EC) by 28.52%, 3.38%, and 2.27%, respectively, compared to the control. Similarly, applying nitrogen at 150 kg ha⁻1 using FYM significantly improved SOC, SOM, SMC, and SBD. At the same rate, using PM as a nitrogen source enhanced STN and SMN while reducing soil pH and EC. In conclusion, this study shows that applying biochar at 30 t ha⁻1 combined with nitrogen at 150 kg ha⁻1, sourced from either PM or FYM, offers great potential for improving soil fertility and promoting carbon sequestration in alkaline soils of semi-arid regions. These findings highlight the value of integrating BC and organic N sources for enhancing agroecosystem sustainability. Thus, this study provides a promising pathway to enhance soil quality, improve crop productivity, and support sustainable agricultural practices in challenging environments.
Salinity Monitoring and Modelling at Different Scales: An Editorial Overview
Authors: Farzamian Mohammad , Gonçalves Maria Conceição , Ramos Tiago B.
Published: November 2024

Soil salinization is a significant abiotic process affecting arid, semi-arid, and sub-humid regions worldwide [...]
The Impact of High-Standard Scenic Areas Construction on County-Level Carbon Emissions and Its Spatial Spillover Effects: Evidence from a Quasi-Natural Experiment
Authors: Xu Ke , Zhang Rui , Tong Yun
Published: November 2024

This study investigated for the first time the tourism–carbon emissions nexus based on the destination construction perspective, using the China’s national scenic areas (CNSA) construction as a vehicle for concretization. A multi-source county panel dataset of 29,628 samples was constructed. The staggered Difference-in-Differences (DID) model and spatial DID model were further formulated. The findings show that: (1) the CNSA resulted in a 0.1024% reduction in carbon emission intensity (CEI) in treatment counties relative to non-treatment counties, and although the effect exhibits a delay, it persists and intensifies over time; (2) our heterogeneity results indicate that the inhibiting effect is significantly more pronounced in the western, eastern, and county subsamples; and (3) the spatial DID analysis reveals that the CNSA exerts a negative spatial spillover effect on CEI. This work enhances comprehension of the tourism–carbon emissions nexus, with implications for advancing regional carbon emission reduction policy strategies.
Artificial Intelligence in Breast Cancer Diagnosis and Treatment: Advances in Imaging, Pathology, and Personalized Care
Authors: Uchikov Petar , Khalid Usman , Dedaj-Salad Granit Harris , Ghale Dibya , Rajadurai Harney , Kraeva Maria , Kraev Krasimir , Hristov Bozhidar , Doykov Mladen , Mitova Vanya , Bozhkova Maria , Markov Stoyan , Stanchev Pavel
Published: November 2024

Breast cancer is the most prevalent cancer worldwide, affecting both low- and middle-income countries, with a growing number of cases. In 2024, about 310,720 women in the U.S. are projected to receive an invasive breast cancer diagnosis, alongside 56,500 cases of ductal carcinoma in situ (DCIS). Breast cancer occurs in every country of the world in women at any age after puberty but with increasing rates in later life. About 65% of women with the BRCA1 and 45% with the BRCA2 gene variants develop breast cancer by age 70. While these genes account for 5% of breast cancers, their prevalence is higher in certain populations. Advances in early detection, personalised medicine, and AI-driven diagnostics are improving outcomes by enabling a more precise analysis, reducing recurrence, and minimising treatment side effects. Our paper aims to explore the vast applications of artificial intelligence within the diagnosis and treatment of breast cancer and how these advancements can contribute to elevating patient care as well as discussing the potential drawbacks of such integrations into modern medicine. We structured our paper as a non-systematic review and utilised Google Scholar and PubMed databases to review literature regarding the incorporation of AI in the diagnosis and treatment of non-palpable breast masses. AI is revolutionising breast cancer management by enhancing imaging, pathology, and personalised treatment. In imaging, AI can improve the detection of cancer in mammography, MRIs, and ultrasounds, rivalling expert radiologists in accuracy. In pathology, AI enhances biomarker detection, improving HER2 and Ki67 assessments. Personalised medicine benefits from AI’s predictive power, aiding risk stratification and treatment response. AI also shows promise in triple-negative breast cancer management, offering better prognosis and subtype classification. However, challenges include data variability, ethical concerns, and real-world validation. Despite limitations, AI integration offers significant potential in improving breast cancer diagnosis, prognosis, and treatment outcomes.
Characterization of Novel Species of Potassium-Dissolving Purple Nonsulfur Bacteria Isolated from In-Dyked Alluvial Upland Soil for Maize Cultivation
Authors: Thu Le Thi My , Xuan Ly Ngoc Thanh , Nhan Tran Chi , Quang Le Thanh , Trong Nguyen Duc , Thuan Vo Minh , Nguyen Tran Trong Khoi , Nguyen Phan Chi , Thuc Le Vinh , Khuong Nguyen Quoc
Published: November 2024

Potassium (K) is immobilized within the clay minerals, making it unavailable for plant use. Therefore, the current study aimed to (i) select isolates of purple nonsulfur bacteria that can dissolve K (K-PNSB) and (ii) evaluate the production of plant-growth-promoting substances by the K-PNSB isolates. The results revealed that from in-dyked alluvial soils in hybrid maize fields, 61 K-PNSB isolates were obtained under the pH 5.50 conditions. The total dissolved K content (Kdis) by the 61 K-PNSB isolates fluctuated from 56.2 to 98.6 mg L−1. Therein, three isolates, including M-Sl-09, M-So-11, and M-So-14 had Kdis of 48.1–48.8 mg L−1 under aerobic dark condition (ADC) and 47.6–49.7 mg L−1 under microaerobic light condition (MLC). Moreover, these three isolates can also fix nitrogen (19.1–21.5 mg L−1 and 2.64–7.24 mg L−1), solubilize Ca-P (44.3–46.8 mg L−1 and 0.737–6.965 mg L−1), produce indole-3-acetic acid (5.34–7.13 and 2.40–3.23 mg L−1), 5-aminolevulinic acid (1.85–2.39 and 1.53–2.47 mg L−1), siderophores (1.06–1.52 and 0.92–1.26 mg L−1), and exopolymeric substances (18.1–18.8 and 52.0–56.0%), respectively, under ADC and MLC. The bacteria were identified according to their 16S rDNA as Cereibacter sphaeroides M-Sl-09, Rhodopseudomonas thermotolerans M-So-11, and Rhodospeudomonas palustris M-So-14. These potential bacteria should be further investigated as a plant-growth-promoting biofertilizer.
In Vitro Cholesterol Uptake by the Microflora of Selected Kefir Starter Cultures
Authors: Ziarno Małgorzata , Zaręba Dorota , Ścibisz Iwona , Kozłowska Mariola
Published: November 2024

Kefir, a fermented milk beverage, is recognized for its potential health benefits, including its cholesterol-lowering properties. This study demonstrated that selected kefir starter cultures, including Lactococcus strains and yeasts, significantly reduce cholesterol-binding capacity under simulated gastrointestinal conditions, underscoring the challenges of probiotic delivery. We compared the performance of these cultures under laboratory conditions (growth broths) and simulated digestive juice models. Lactococcus strains showed significant differences in cholesterol binding between the two environments, highlighting the limitations of relying solely on laboratory testing. Yeast cultures also exhibited greater cholesterol binding in their native broths, but their survival was limited in digestive models. Our findings suggest that effective probiotic formulations should prioritize strains with high cholesterol-binding capacity and robust survival rates throughout the digestive tract. This study provides valuable insights for future research on the mechanisms behind these functionalities and the potential of kefir yeast strains for use in human digestive models. Our results can be used to inform the development of improved probiotic formulations for cholesterol management.
Ectopic Kidney, a Challenging First Trimester Diagnosis—Case Report and Literature Review
Authors: Poenaru Mircea-Octavian , Augustin Fernanda-Ecaterina , Vâlcea Ionuț-Didel , Sima Romina-Marina , Amza Mihaela , Bălălău Oana Denisa , Pleș Liana
Published: November 2024

(1) Background: Crossed fused renal ectopia is a rare migration and fusion renal anomaly, more frequently affecting males, with an incidence of between 1:2000 and 1:7500 observed at autopsy. (2) Case presentation: This paper presents the case of a 34-year-old woman, IIIG IIIP, who presented to our clinic for a first-trimester screening evaluation. The risk calculation was performed using the Fetal Medicine Foundation’s first-trimester screening software, version 2.8.1. The screening indicated a low risk for aneuploidies, but the ultrasound scan revealed an empty right renal fossa in the standard coronal section. A more detailed axial examination raised the suspicion of crossed fused renal ectopia. No other anomalies were detected. The morphological scans conducted in the second and third trimesters confirmed and upheld the diagnosis initially established in the first trimester. The fetus did not develop any potential antepartum complications. The patient gave birth via caesarean section at 36 weeks to a live female infant, weighing 3000 g, with an APGAR score of 9 at 1 min. Postnatally, the first trimester diagnosis of the renal malformation was confirmed. (3) Conclusions: Crossed fused renal ectopia, probably the rarest renal migration anomaly, can be diagnosed as early as the first trimester of pregnancy.
Effects of Intra-Articular Stromal Vascular Fraction Injection on Clinical Symptoms and Cartilage Health in Osteoarthritic Knees: A Single-Center Pilot Study
Authors: Lin Chun-Ru , Lin Chia-Nan , Lee Chung-Chen , Chen Yong-Chen , Chen Yu-Jen , Chen Ming-Hao , Lin Yu-Chih , Chang Shu-Hao
Published: November 2024

Osteoarthritis (OA) is a prevalent form of arthritis worldwide. Intra-articular stromal vascular fraction (SVF) injections are a potential therapeutic option for patients with OA. This study aims to assess the effects of intra-articular SVF injections on knee OA. Ten patients with knee OA participated in this study. After administering them with intra-articular SVF injections, their outcomes were evaluated using various questionnaires. MRI T2 mapping was conducted and compared before the intervention and 6 months after. All the data underwent analysis using various tests. Significant differences were observed in the change of Western Ontario and McMaster Universities Arthritis Index, VAS, and Knee Injury and Osteoarthritis Outcome Score between pre-intervention and 6 months post-intervention. The T2 values were significantly lower in the anterior superficial layer of the medial femoral cartilage and middle superficial layer of the lateral femoral cartilage. However, no positive effects were observed in any other regions of the knee cartilage. This study revealed significant differences between the pre- and 6-month post-intervention questionnaires. However, the T2 values did not show consistent changes across all regions of the knee cartilage. Despite positive effects in two regions, the degenerative process appeared to continue in other regions during the tracking period.
Effects of Inspiratory Muscle Training in People with Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis
Authors: Han Bing , Chen Zhuying , Ruan Bing , Chen Yongjie , Lv Yuanyuan , Li Cui , Yu Laikang
Published: November 2024

This study aimed to investigate the effects of inspiratory muscle training (IMT) on inspiratory muscle strength, dyspnea, and quality of life (QOL) in COPD patients. A comprehensive search was undertaken on the Web of Science, Scopus, Embase, Cochrane, and PubMed databases, encompassing data published up to 31 March 2024. A meta-analysis was subsequently conducted to quantify the standardized mean difference (SMD) and 95% confidence interval (CI) for the effects of IMT in COPD patients. Sixteen studies met the inclusion criteria. IMT significantly improved inspiratory muscle strength (SMD, 0.86, p < 0.00001), dyspnea (SMD = −0.50, p < 0.00001), and QOL (SMD = 0.48, p = 0.0006). Subgroup analysis showed that <60% maximal inspiratory muscle pressure (PImax) IMT (inspiratory muscle strength, SMD = 1.22, p = 0.005; dyspnea, SMD = −0.92, p < 0.0001), IMT conducted for ≤20 min (inspiratory muscle strength, SMD = 0.97, p = 0.008; dyspnea, SMD = −0.63, p = 0.007; QOL, SMD = 1.66, p = 0.007), and IMT conducted >3 times per week (inspiratory muscle strength, SMD = 1.06, p < 0.00001; dyspnea, SMD = −0.54, p < 0.00001; QOL, SMD = 0.48, p = 0.0009) had greater effects. This meta-analysis provides clinicians with evidence supporting the recommendation that COPD patients engage in IMT at <60% PImax for more than 3 times per week, with each session lasting no more than 20 min, to improve inspiratory muscle strength, dyspnea, and QOL.