bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of prediction of water solubility and lipophilicity of coumarins by free cheminformatics tools
Authors:   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia, Bešlo Drago , Agić Dejan ,   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia, Rastija Vesna ,   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia, Karnaš Maja ,   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia, Šubarić Domagoj ,   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia, Lučić Bono ,   University J. J. Strossmayer in Osijek, Faculty of Agrobiotechnical Sciences Osijek, Croatia
Published: November 2023

Pharmacokinetics of drugs involves the study of the drug’s path through the body, from its introduction to its final excretion from the body (Absorption, Distribution, Metabolism, and Excretion (ADME)). The basis of pharmacokinetic tests provides insight into the behavior of the tested substance after it is introduced into the body. They include consideration of the physicochemical properties of the medicinal substance, as well as its biopharmaceutical properties. Experimental measurements are often demanding and take a long time to conclude the continuation of further research, whether it is a natural or synthesized substance that could be used as a medicine. In silico testing is resorted to because of the high cost of experimental testing. That is why today more and more research is done theoretically using different chemoinformatics tools. Using the results obtained theoretically or in silico related to key parameters such as solubility, degree of dissociation, and binding to plasma proteins, it is possible to successfully predict the fate of the drug in the body, i.e., its bioavailability. There is a large number of software that are free to obtain the desired information about solubility, metabolism, distribution, and excretion from the organism. In this work, we decided to examine the solubility and lipophilicity of coumarin with three chemoinformatics tools.
Interaction energy and decomposition of interaction energy of halo-substituted phthalimide with carbon nanotube
Authors:   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Zrilić Sonja S. , Živković Jelena M. ,   Innovative center of the Faculty of Chemistry in Belgrade, Serbia, Zarić Snežana D. ,   University of Belgrade, Faculty of Chemistry, Serbia
Published: November 2023

Interaction energy of phthalimide (ph) with carbon nanotube (CNT) calculated at SAPT0 level with a mixed basis set (6-31G* for CNT and 6-311G* for ph) is -19.51 kcal/mol. Halo-substitution of the phthalimide generally strengthens its interaction with the CNT and interaction energies are in the range from -21.02 kcal/mol to -22.62 kcal/mol going from ph-Cl to ph-I. However, interaction energy for phthalimide substituted with F atom (ph-F) is weaker (-18.81 kcal/mol) than for non-substituted phthalimide. For ph-Cl, ph-Br, ph-I, the total interaction energy increases with the higher halogen atomic number, because of the significant dispersion term and, less pronounced, electrostatic term increase. The smallest dispersion is calculated for ph-F/CNT (-28.72 kcal/mol), while the remaining systems range from -31.51 kcal/mol for ph/CNT to -35.78 kcal/mol for ph-I/CNT. Apart from dispersion, the system with fluorine has a less pronounced electrostatic term than other substituted phthalimides and does not follow trends observed for other systems.
Identification of small molecule binding sites using CmDock
Authors:   University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, Slovenia, Jukić Marko , Bren Urban ,   University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, Slovenia
Published: November 2023

Identification of binding sites for small molecules is critical in light of modern in silico and experimental methods for structure elucidation such as AlfaFold and CryoEM, respectively. The total number of entries in the PDB database is 208,702 through July 2023, and there are a large number of structural data without similar experimental entries and mechanistic or small molecule data. Herein, we report a simple, rapid, and efficient protocol for the identification of drug-like binding sites of small molecules using extended sampling with the self-developed molecular docking software CmDock. The protocol consists of preparing a docking receptor using the RbtProteinMapper method, which uses a full protein surface as a reference. Then, a series of drug-like interaction sampling probes are docked in an extended sampling of 1000 or more runs. The binding conformations calculated by the probes are analyzed using PacMAP reduction and DBSCAN density clustering to identify binding sites. The protocol is capable of identifying known binding sites of small molecules in a very short time frame. In addition, we demonstrate the application of the method to a known DNA Gyrase as well as to a STAT3 NTD domain system.
A comprehensive in silico protocol for fast automated mutagenesis and binding affinity scoring of protein-ligand complexes
Authors:   University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, Slovenia, Kralj Sebastjan , Hodošček Milan ,   National Institute of Chemistry, Theory Department, Slovenia, Jukić Marko ,   University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, Slovenia,   Institute of Environmental Protection and Sensors, Slovenia, Bren Urban ,   University of Maribor, Faculty of Chemistry and Chemical Engineering, Laboratory of Physical Chemistry and Chemical Thermodynamics, Slovenia
Published: November 2023

Protein-protein interactions (PPI) are critical for cellular functions, host-pathogen dynamics and are crucial with drug design efforts. The interaction of proteins is dependent on the amino acid sequence of a protein as it determines its binding affinity to various molecules, including drugs, DNA, RNA, and proteins. Polymorphisms, natural DNA variations, affect PPIs by altering protein structure and stability. Computational chemistry is vital for the prediction of ligand-protein interactions through techniques such as docking and molecular dynamics and can elucidate the changes in energy associated with such mutations. We present a user-friendly protocol that uses the INTE command of CHARMM to predict the effects of mutations on PPIs. This command-line tool automates mutation analysis and interaction energy estimation, is applicable to different ligand types (protein, DNA, RNA, ion, small molecule) and provides various other features. The energy values yield absolute and normalized heat maps that allow rapid identification of stabilizing and destabilizing mutations. Our protocol forms the basis for automated programs that facilitate studies of binding-altering mutations in host-pathogen, protein-protein, and drug-target interactions.
Investigating the potential inhibitory effect of the megaphone (molecule) on nasopharyngeal cancer growth factor receptors
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Milanović Žiko , Antonijević Marko ,   University of Kragujevac, Institute for Information Technologies, Serbia, Simijonović Dušica ,   University of Kragujevac, Institute for Information Technologies, Serbia, Đorović Jovanović Jelena ,   University of Kragujevac, Institute for Information Technologies, Serbia, Stanojević Pirković Marijana ,   University of Kragujevac, Faculty of Medical Sciences, Serbia
Published: November 2023

Nasopharyngeal cancer (NPC) is a type of cancer that originates in the nasopharynx, which is the upper part of the throat behind the nasal cavity. Like other cancers, the growth and progression of nasopharyngeal cancer are influenced by various proteins involved in cell signaling, growth regulation, and tumor development such as Epidermal Growth Factor Receptor (EGFR), Vascular Endothelial Growth Factor (VEGF), Fibroblast growth factor receptor (FGFR) and Cyclin D1 (CD1). Megaphone ((1′R,5′R,7R,8S)-7-Hydroxy-3,4,5,5′-methoxy-5′,6′-dihydro-2′H-8,1′-neolign-8′-en-2′-one, MG) is the main component of the alcohol extract of the ground root of Aniba megaphylla, which in vitro inhibits the growth of cells derived from human nasopharyngeal carcinoma. Due to the lack of literature data, the main goal of this study was to examine the first step of the mechanisms of anti-carcinogenic activity by examining the inhibitory potential of MG against the above-mentioned cancer cell growth factor receptors.
Chromeno-pyrimidine-type compounds (part II): in vitro evaluation of antioxidant potential
Authors:   University of Kragujevac, Institute for Information Technologies, Serbia, Avdović Edina , Simijonović Dušica ,   University of Kragujevac, Institute for Information Technologies, Serbia, Milanović Žiko ,   University of Kragujevac, Institute for Information Technologies, Serbia, Jovičić Milić Sandra ,   University of Kragujevac, Institute for Information Technologies, Serbia, Roca Sunčica ,   NMR Centre, Ruder Bošković Institute, Croatia, Vikić-Topić Dražen ,   Juraj Dobrila University of Pula, Department of Natural and Health Sciences, Croatia
Published: November 2023

The chromeno and pyrimidine classes compounds include a variety of hybrid molecules displaying diverse biological actions. Although they have been examined for many years, these compounds are still of interest due to their facile chemical transformations. The presence of chromeno and pyrimidine structural motifs in many drugs, prompted us to investigate the antioxidant features of compounds 5-(7-bromo-2,4-dioxo-1,3,4,5-tetrahydro-2H-chromeno[2,3-d]pyrimidin-5-yl) pyrimidine-2,4,6(1H,3H,5H)-tri-one (CP-1) and 8,9- ihydroxy-2H-chromeno[2,3-d]pyrimidine-2,4(3H)-dione (CP-2). In this paper, we investigated in vitro antioxidant properties of selected chromeno-pyrimidine derivatives. The percentage activity of the tested compounds CP-1 and CP-2, as well as the quercetin standard, NDGA, against the DPPH radical in concentrations of 25 M, 50 M and 100 M was tested. Compound CP-2 was found to have an exceptional efficacy of 92% at a concentration of 25 μM. In addition, the IC50 value confirms a high antiradical power against DPPH radicals for the compound CP-2 (IC50 = 3.5μM) and a moderate activity for the compound CP-1 (IC50 = 55.4 μM).
Elderly People and Discrimination: Prevention and Reaction
Authors:   , Faculty of Law of the University of the Business Academy in Novi Sad, Pavlović Zoran
Published: November 2023

This publication contains the contributions in which different disciplinary, theoretical, and methodological approaches were employed to analyse numerous problems and topics of importance for understanding the phenomenon of discrimination against the elderly and look for an adequate strategy for building resilience and empower the elderly. The papers in the publication are divided into the four sections each of them dealing with the different public domain. The first section of the collection is focused on legal aspect, the second on criminology and victimology, the third one deals with the human rights of the elderly and finally, the concluding section is dealing with social inclusion and digital aspects of ageing, but also includes one paper about social and professional status of senior female scholars in Serbia.
Financial Literacy Moderation on the Influence of E-Wallet Usage and Locus of Control on Consumtive Behavior of Generation Z in Denpasar City
Authors:   Lecturer of the Faculty of Economics, Warmadewa University, Bali-Indonesia, Niti Widari Dewa Ayu Putu , Pulawan I Made ,   Lecturer of the Faculty of Economics, Warmadewa University, Bali-Indonesia, Setini Made ,   Lecturer of the Faculty of Economics, Warmadewa University, Bali-Indonesia
Published: November 2023

In the city of Denpasar, Bali, generation Z is a group that is increasingly using digital technology in everyday life. One digital technology that is widely used by generation Z is e-wallet. Even though the use of e-wallets among generation Z is increasing, there are still problems in optimal financial management. This can be seen from the increase in consumer behaviour which has not been balanced with an adequate level of financial literacy. Therefore, knowledge in personal financial management is needed to help them make the right financial decisions. This research aims to analyse Financial Literacy Moderation on the influence of E Wallet Usage and Locus of Control on Generation Z's Consumptive Behaviour in Denpasar City. The subjects in this research are Generation Z in Denpasar City. Descriptive measurements and analysis were carried out to obtain an overview or portrait of the respondents. Data was collected through a questionnaire instrument (Likert Scale) which had been tested for validity and reliability. Meanwhile, the sample was determined as 105 people using incidental sampling technique. Next, the collected data was analysed using the SEM-PLS analysis technique. The research results state 1.Ewallet usage has a negative and significant effect on the consumptive behaviour of generation Z in the city of Denpasar. 2. Locus of control has a positive and significant effect on the consumptive behaviour of generation Z in the city of Denpasar. 3. Financial literacy has a negative and significant effect on the consumptive behaviour of generation Z in the city of Denpasar. 4 .Financial literacy moderates the influence of e-wallet usage on the consumptive behaviour of generation Z in the city of Denpasar 5. Financial literacy moderates the influence of locus of control on the consumptive behaviour of generation Z in the city of Denpasar.
Elaboration of Self-Compacting Concrete (SCC) for Reinforcing Reinforced Concrete Beams
Authors:   Department of Civil Engineering, Materials and durability of constructions laboratory, University of the Mentouri Brothers, Constantine1, Algeria, Chibani Nawel , Beroual Ahmed ,   Department of Civil Engineering, Materials and durability of constructions laboratory, University of the Mentouri Brothers, Constantine1, Algeria
Published: November 2023

This paper presents an experimental study of the four-point simple bending behaviour of low strength reinforced concrete beams, reinforced with self-compacting concrete (SCC) with two different strength classes (30 and 40MPa) and ordinary strength concrete (30MPa).And to compare the simple bending behaviour of beams reinforced with (SCC) to that of beams reinforced with ordinary concrete, is taken as a reference control concrete. The rheological properties of the materials used were determined using the slump-flow, L-box, V-funnel and sieve stability tests. The mechanical properties of studied concretes were evaluated at 7 and 28 days of cure. The results obtained have shown that self-compacting concrete (SCC) appears to be a very promising material for the reinforcement of concrete structures. The (SCC) offer increased stability, manoeuvrability and adequate filling capacity. This contributed to the improved performance of the self-compacting concrete (SCC) reinforcement configuration compared to ordinary concrete as a reinforcement material.
The Chemical Management Using Safety Theory for Farmers in Ubon Ratchathani Province
Authors:   Faculty of Public Health Ubon Ratchathani Rajabhat University., C. Yokpnonchanachai , Y., Paengprakhon ,   Faculty of Public Health Ubon Ratchathani Rajabhat University., J. Duangsri ,   Faculty of Public Health, Amphoe Mueang, Ubon Ratchathani, 34000, Thailand.
Published: November 2023

This is quasi-experimental research on the chemical management using the safety theory for farmers in Ubon Ratchathani Province. The population was the select 782 households voluntarily to participate in the research project. One person per household was selected. As a result, a total of 213 samples were obtained. The research was conducted by implementing a safety program based on the 3E principle for 3 consecutive months to the samples. The data were analyzed using descriptive statistics and inferential statistics (paired sample t-test). The results revealed that most of the farmers (94.8%) used liquid chemicals, especially herbicides, aphicides and insecticides with a high level of exposure to chemicals. After the safety program was implemented, the satisfaction also significantly increased compared to that of before the safety program was implemented (P-Value < 0.001In terms of Engineering, according to the design of a chemical fume hood, the air velocity was 0.31 m/s compared to the ACGIH standard that the air velocity must be between 0.25-0.5 m/s. Therefore, the chemical fume hood met the ACGIH standard. In terms of Enforcement, it gained a high level of satisfaction. In conclusion, the chemical management based on the 3E principle can appropriately manage safety in chemical use in the community by enhancing farmers’ knowledge and attitudes, leading to safety behaviors in chemical use in the community in a better direction. Therefore, it can be applied to safety management in other communities.
Critical Review of Digital Entrepreneurship and Performance of Insurance Companies in Nigeria
Authors:   Skyline University, Nigeria, Olufunke Jenyo, Bola , Oladeji Oladoke Sunday ,   Kwara State University, Malete, Adenika Abimbola Oluwasogo ,   Forestry Research Institute of Nigeria, Olasehinde Isaac Oladapo ,   Bingham University Karu, Nassarawa State, Otayokhe Esther Yemi ,   Institute of Finance and Management Studies Kwara State Polytechnic, Ilorin, Ajiboye Wale Thomas ,   Institute of Finance and Management Studies Kwara State Polytechnic, Ilorin
Published: November 2023

This study critically reviewed digital entrepreneurship and the performance of Insurance companies in Nigeria. Digital products and mobile technology were used to explore their effects on innovation and public trust in insurance. The adoption of digital tools eliminates brokers paperwork and claims process, it has the capabilities to minimize fraud - leading to reduced time, effort, and costs. The scope of the study comprises all the InsurTech insurance companies in Nigeria. This study describes the desktop and structured research method used in attaining the stated research objectives. Findings revealed that the company’s product, digital services, and novel services influence the performance of insurance companies in Nigeria. Further, Mobile technology has a positive and significant influence on public trust in Nigerian insurance. Findings revealed that more effective and efficient, smooth communication influences the performance of insurance companies in Nigeria. This study concludes that digital products and mobile technology have a positive and significant influence on innovation and public trust in Nigerian insurance. This study recommends that more company products need to be designed to be digital according to client’s preferences. And mobile technology can be utilized to reach out to millions of insurance clients. It makes the insurance business more effective and efficient. Proper utilization of mobile technology can improve the communication between the insurer and the insured.
From Trainee to Adapter: A Mapping of Leadership Competencies of Adapter Cadet in the Air Force Academy
Authors:   Cadet Intendent of the 4º Squadron of the Air Force Academy in Brazil., Lima Natália Pim Lucas Costa , Leitão Raphael de Almeida ,   Infantry Captain. Master's Student of the Postgraduate Program in Aerospace Science at Air Force University, PPGCA-UNIFA, Brazil.
Published: November 2023

The beginning of military training of those who join the Armed Forces is one of the most important stages of their professional lives. At the Air Force Academy (AFA), this period is known as the Military Adaptation Internship (EAM), and demands a lot of dedication of the candidates, called trainees, and of the Officers of the Cadet Corps Command, who are responsible for adapting inexperienced young people to the new and strenuous routine. In order to carry out such a challenge, it is necessary that the Officers should be assisted by a group of cadets to conduct the various activities that will positively influence the trainees during their first days in the barracks. These cadets, now called as adapters, are chosen by their Squadron Command through a selection process that should occur as uniformly as possible. In order to provide such an important service, it is essential that the adapters are properly trained, as they will reflect on their subordinates the main attributes of an Air Force cadet and serve as a reference to them. However, it is noted that nowadays, the selection process for adapters is not formally standardized. In this sense, the objective of this work is to contribute to the mapping of the competencies that the adapter cadet needs to have developed by the beginning of the EAM, in order to better fulfill the tasks to which he/she will be assigned during this internship. The transactional leadership theory will serve as the basis for identifying knowledge, skills and attitudes in the cognitive, affective and psychomotor fields of the students, in order to explain the importance of each one. The methodology consists of an applied, descriptive and explanatory research, using a questionnaire with the Officers of the Squadron Commands of AFA, to analyze the sample of competencies to be suggested and implemented. In addition, it was done a bibliographic review of the most relevant articles, books and academic works on the subject, and paying special attention to the publications of the Air Force Command that deal with the issues at hand. At the end of this research, the main aspects of an adapter cadet were highlighted, emphasizing the meaning of each item and how it can assertively reflect on the career of a future officer of the Brazilian Air Force.
A Study on the Effects of Risk-taking Propensity and Entrepreneurship Education on Entrepreneurial Intention: Using Entrepreneurial Intention Model
Authors:   The Foodservice Management Society Of Korea, Hong Jung-Hwa
Published: November 2023

In accordance with the increasing attention in entrepreneurship among tourism industry, this study carried out with the aim of verifying factors affecting on tourism major students’ entrepreneurial intention using modified entrepreneurial intention model. Statistical analysis was conducted based on 216 valid questionnaire answers. SPSS 23.0 and AMOS 23.0 were used to analyze the collected data. Results show that risk-taking propensity had a significant positive effect on entrepreneurial attitude. And subjective norm(SN) had a significant positive relationship with entrepreneurial attitude, perceived behavioral control(PBC) and entrepreneurial intention as well. Both entrepreneurial attitude and PBC had a significant positive effect on entrepreneurial intention. The moderating effect of entrepreneurship education was found on the relationships between risk-taking propensity and entrepreneurial attitude, SN and entrepreneurial attitude, SN and PBC. Based on these findings, this study provide theoretical and practical implication for promoting entrepreneurial intention of tourism major students. It also suggests the improvement of entrepreneurial education at universities.
A Comparative Study on User Perception and Satisfaction According to Perceived Dietary Benefits After Using School Meal Voucher
Authors:   The Foodservice Management Society Of Korea, Lee Hyun-Woo , Chong Yu-Kyeong
Published: November 2023

This study analyzed the difference in perception and satisfaction of school meal vouchers according to perceived dietary benefits after using school meal vouchers. As a result of the study, satisfaction with alternative support is also high if the beneficiary thinks that the school meal voucher has benefited his or her diet, such as helping to pay for food. Therefore, satisfaction depends on how the beneficiary perceives alternative support for school meals, including school meal vouchers, which can be interpreted as a way to examine in-depth areas that show low satisfaction, such as voucher item nutrition standards, and reflect them in policies and systems. It is also expected to provide a foundation for preparing policy-making measures that reflect the opinions of those directly related to the policy, rather than policies based on the opinions or assumptions of policymakers.
Molecular identification and antifungal susceptibility of Candia tropicalis and Candida parapsilosis isolated from cancer patients
Authors: Wijendra W. A. Somalatha , Samarappulige Chathma Ganguli , Dasanayaka Nilanthi , Kaushalya Gaya , Ramesh R , Gunasekara Samanmalee
Published: November 2023

Candida species cause  systemic Candidiasis in immunocompromised cancer patients. Currently, a large proportion of bloodstream infections are due to non-Candida albicans Candida spp. (Candida species other than C. albicans), with Candida tropicalis and Candida parapsilosis being the most isolated Candida species from cancer patients. In this study, 52 Candida isolates collected from cancer patient at the Apeksha Hospital, Maharagama, Sri Lanka. Molecular identification of isolated Candida samples employed a multiplex PCR technique utilizing specific primer pairs for two strains of both Candida tropicalis and Candida parapsilosis. Furthermore, to determine the susceptibility of the identified isolates, antifungal susceptibility testing was conducted using the disk diffusion method on Mueller-Hinton agar medium. Six antifungal drugs, including Fluconazole, Itraconazole, Clotrimazole, Miconazole, Ketoconazole, and Amphotericin B, were utilized in the susceptibility testing. In this study 38% was identified as Candida tropicalis II  while, 31% was  identified  as  Candida parapsilosis II. According to this study Fluconazole was the most susceptible drug against both species and Amphotericin B was the least susceptible drug. Ketoconazole, Clotrimazole, Itraconazole and Miconazole showed varying degrees of susceptibility patterns. The study concludes that multiplex PCR is a better approach for the identification of both Candida tropicalis and Candida parapsilosis for clinical and diagnostic purposes and Fluconazole is the best antifungal drug against Candida parapsilosis, while caution is advised when using Amphotericin B as a treatment option since its’ low susceptible rates.
Effects of Osmo-priming Duration on Rice (Oryza sativa L.) Seed Germination and Seedling Parameters
Authors: Ekeruo Godspower , Iyorkaa Nater , Kortse Peter , Dughdugh Paul , Ugbaa Macsamuel , Ochoche Okoh John
Published: November 2023

The study was conducted to determine the effects of osmo-priming duration on the germination and seedling parameters of rice seeds. Two rice varieties FARO 44 and FARO 59 were used for the study. Three osmo-priming chemicals (Calcium chloride CaCl, Potassium nitrate KN03 and Polyethylene glycol PEG6000) and four priming duration's (Control, 12, 24 and 36 hours in the above chemical solutions) as treatments in the study. Data were collected on the following parameters; final germination percentage, germination rate index, mean germination time, coefficient of velocity of germination, seedling height, seedling fresh weight and seedling dry weight. For most of the parameters, osmo-priming duration was statistically significant. The results showed that chemical priming treatments had significant effect on final germination percentage, mean germination time, germination rate index, coefficient of velocity of germination, seedling height and seedling weight of rice seeds. Primed with KNO3, PEG6000 and CaCl solution for a period of 24 - 36 hours is a remarkable technique for improving seed germination and seedling growth of rice. The no priming treatment showed the lowest final germination percentage, mean germination time, germination rate index, coefficient of velocity of germination, seedling height and seedling weight of rice seeds. Therefore, the present study concludes that improvement of germination capacity and rapidity of germination of rice seed could be possible by employing osmo-priming duration treatments.
Validation of the Measures for Activities of Daily Living Function: the Korean Version of the University of California San Diego Performance-Based Skills Assessment
Authors:   Korean Association For Geriatric Psychiatry, Joo Chaelin , Kim Kayoung , Lee Won Hye , Han Joo Hyun , Noh Eunjung , Yim Seon Jin
Published: November 2023

Objective: The study’s aim was to evaluate the validity of the Korean version of the University of California San Diego Performance- based Skills Assessment, Validation of Intermediate Measures (K-UPSA-2-VIM) in patients with dementia (D), mild cognitive impairment (MCI), and cognitive normal control group (CN).
Methods: Study participants were 25 patients with D, 43 patients with MCI, and 111 controls with CN group, respectively. For cognitive assessment, Mini Mental State Examination, Consortium to Establish a Registry for Alzheimer’s Disease neuropsychological battery, and Clinical Dementia Rating were used. For functional assessment, Barthel-Activities of Daily Living, Instrumental Activities of Daily Living, Dementia Screening questionnaire, and K-UPSA-2-VIM were used.
Results: Statistically significant differences were observed in all subdomains and total score of the K-UPSA-2-VIM among three cognitive groups. K-UPSA-2-VIM demonstrated 75.7% of sensitivity and 65.1% of specificity, with an area under the curve (AUC) of 0.731 (95% confidence interval [CI]: 0.641-0.821, p<0.001) in discriminating between CN and MCI groups. In discriminating between MCI and D groups, 76.7% of sensitivity and 64.0% of specificity, with an AUC of 0.706 (95% CI: 0.580-0.833, p=0.005) were demonstrated.
Conclusion: The K-UPSA-2-VIM is useful to evaluate activities of daily living function in Korean patients with D and MCI.
The Effectiveness of Computerized Cognitive Training Program for Older Adults With Mild Cognitive Impairment: Preliminary Study
Authors:   Korean Association For Geriatric Psychiatry, Kim Hyun , Lee Kang Joon
Published: November 2023

Objective: As the elderly population increases, the proportion of neurocognitive disorder is increasing. Accordingly, research on cognitive intervention therapy to prevent neurocognitive disorder is also becoming active. In particular, this study attempted to evaluate changes in cognitive function before and after training and verify their effectiveness by implementing a computerized cognitive training program for patients with mild cognitive impairment.
Methods: A computerized cognitive training program was conducted for 15 patients with mild cognitive impairment. It was conducted twice a week, 30 minutes, and 16 times for 8 weeks, and neurocognitive function was evaluated before and after training. The neurocognitive function tests are as follows; Seoul Neuropsychological Screening Battery, Korean version of Montreal Cognitive Assessment (K-MoCA), Clinical Dementia Rating (CDR), Korean Instrumental Activity of Daily Living (K-IADL), Korean Neuropsychiatric Inventory (K-NPI), and Memory Age-associated Complaint Questionnaire (MAC-Q).
Results: There was a statistically significant improvement in memory domain after the implementation of the computerized cognitive training program, but no significant changes in attention, language ability, visuospatial function, and frontal lobe executive function. Among the memory areas, the Seoul Verbal Learning Test: Delayed Recall, Rey Complex Figure Test: Delayed Recall, and Rey Complex Figure Test: Recognition are showed significant improvement. In addition, there was a significant improvement in CDR (sum of box) and K-MoCA scores. There was no statistically significant difference in K-IADL and K-NPI.
Conclusion: Computerized cognitive training programs have been effective in improving memory in patients with mild cognitive impairment. In order to verify the effectiveness of dementia prevention, a long-term study of a larger number is needed. The results of this preliminary study will help develop and apply cognitive training contents in the future.
Influence of Anesthesia on Incidence of Dementias: 8-Year Follow-Up Study
Authors:   Korean Association For Geriatric Psychiatry, Seo Surin , Hyung Won Seok William , Lee Seung-Hoon , Kim Junhyung , Choi Kwang-Yeon , Youn HyunChul , Jeong Hyun-Ghang
Published: November 2023

Objective: Cognitive dysfunction is frequently reported after surgery and anesthesia in elderly patients. This study aims to investigate the incidence of dementia for eight years after anesthesia.
Methods: We extracted the data between 2007 and 2020 from the Health Insurance Review and Assessment Service Database. We analyzed risk of developing dementia after anesthesia using Cox proportional hazard models.
Results: Data were collected from 62,541 patient. Among them, subjects with and without anesthesia were 15,857 and 46,684, respectively. Subjects with anesthesia had more hypertension, diabetes mellitus and hyperlipemia than those without anesthesia. The risk of dementia incidence was found to increase 1.7 times in subjects with anesthesia (hazard ratio=1.751, 95% confidence interval=1.596-1.921). Even after the correction for gender, age, and comorbidity, the statistical significance of this risk remained (hazard ratio=1.662, 95% confidence interval=1.512-1.827).
Conclusion: Our findings suggest that anesthesia possibly contribute on cognitive impairment. Clinician might need closed observation on cognitive function in patients after surgery and anesthesia.
ПРЕСТУПЛЕНИЯ ПРОТИВ МИРА И БЕЗОПАСНОСТИ ЧЕЛОВЕЧЕСТВА
Authors: Г. Т. Шагиева
Published: November 2023

"Статья «Преступления против мира и безопасности человечества представляют серьезную угрозу глобальному порядку и благополучию людей» исследует различные формы преступлений, которые сегодня существуют и представляют серьезную угрозу для международной безопасности, порядка и благополучия человечества. Автор обращает внимание на то, что эти преступления нарушают основные принципы справедливости, уважения прав человека и стабильности международных отношений. В статье рассматриваются несколько ключевых форм преступлений против мира и безопасности человечества. Одной из них является геноцид, который охватывает массовые уничтожения людей на основе их национальности, расы, религии или принадлежности к определенной группе. Это крайне серьезное преступление, имеющее глубокие последствия для пострадавших и международного сообщества в целом. Другая форма преступлений, рассмотренная в статье, – преступления против человечности. Они включают систематическое нарушение прав человека, совершаемое в рамках широкомасштабных атак на гражданское население, таких как массовые убийства, изнасилования, принудительные депортации и пытки. Эти преступления создают глубокие страдания и вызывают разрушение в обществе. Агрессия и терроризм также являются частыми формами преступлений против мира и безопасности человечества. Агрессия представляет собой незаконное использование силы одним государством против другого, что нарушает принципы международного права и мирные отношения. Ключевые слова: Преступление, безопасность, международное право, терроризм, конфликты, военные преступления, киберпреступность, нарушение прав человека. "
Pre-verb reactivation of arguments in sentence processing
Authors: Isono Shinnosuke , Hirose Yuki
Published: November 2023

Major models of sentence comprehension assume that a verb triggers retrieval of preceding thematic arguments from memory to establish argument-verb dependencies. If so, longer argument-verb distance should lead to higher processing load at the verb (a locality effect),since the representation of the argument should suffer from decay and/or interference.However, verb-final languages have often failed to show the expected argument-verb locality effect. A possible account of the lack of the effect is that arguments and adjuncts before the verb reactivate each other, counteracting memory degradation. In a pair of self-paced reading experiments in Japanese, a verb-final language, we found evidence of such pre-verb reactivation.Specifically, there was a locality effect and a similarity-based interference effect at the head of the adverbial that follows the subject, both of which suggest the retrieval of the subject at that point. The results are difficult to accommodate with other accounts of the lack of locality effect, such as a confounding effect of expectation and the inherent locality-insensitivity of verb-final languages. It is further argued that the constructivist analysis of verbal argument structure, which has been developed in generative syntax, provides an explanation for why such pre-verb reactivation takes place. 
PENYULUHAN MP- ASI PADA IBU BALITA DI KELURAHAN LEMBAH LUBUK MANIK KOTA PADANGSIDIMPUAN TAHUN 2022
Authors: NASUTION KHOIRUNNISA , Trisna Ayu
Published: November 2023

ABSTRAK
 
           Bertambahnya umur bayi, bartambah pula kebutuhan gizinya, sebab  itu sejak umur 6 bulan bayi mulai diberi makanan pendamping ASI (MP-ASI). Pemberian MP-ASI yang tidak sesuai akan menimbulkan masalah dalam status gizi anak salah satunya masalah gizi kurang dan gizi buruk.
Tujuan penyuluhan ini adalah: Meningkatkan pengetahuan dan ketrampilan ibu balita dalam pembuatan MP-ASI yang berkualitas, padat gizi dan bervolume kecil dengan memanfaatkan Bahan makanan dari bahan local di di Kelurahan Lembah Lubuk Manik Kota padangsidimpuanTahun 2022.
Bahan dan metode yang digunakan: Menggunakan leaflet dengan metode ceramah dan Tanya jawab.
Hasil Pengabdian  masyarakat ini dari terdapat peningkatan pengetahuan ibu-ibu yang memiliki balita tentang cara membuat MP-ASI dengan  bahan-bahan lokal berkualitas yang ada di sekitar lingkungan, yaitu:  skor pengetahuannya sebelum penyuluhan 50 % (kurang) menjadi 95 % (baik).setelah penyuluhan.
Kesimpulan: Masyarakat membutuhkan informasi tentang bagaimana cara membuat dan menyajikan MP-ASI yang berkualitas dan padat gizi terutama ibu Balita di Kelurahan Lembah Lubuk Manik.
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Kata kunci : Penyuluhan, MP-ASI, Ibu
PEMBERIAN EDUKASI KESEHATAN PADA IBU HAMIL MELALUI MEDIA E-BOOKLET TENTANG PENCEGAHAN STUNTING
Authors: Utaminingtyas Farida , Wahyuni Iin , Maria Atik , Mufidaturrosida Ana
Published: November 2023

ABSTRAK
Stunting adalah kondisi kurang gizi kronis yang dialami seseorang sejak dalam masa kandungan dan awal kelahiran anak, yang dapat meningkatkan angka kematian pada bayi, anak mudah sakit, dan menghambat pertumbuhan motorik maupun mental. Pencegahan stunting dapat dilakukan dengan pemberian edukasi kesehatan pada ibu hamil melalui media E-Booklet, karena mampu menyebarkan informasi lebih ringkas, mudah dimengerti, dan menarik berbasis elektronik. Tujuan pengabdian, memberikan edukasi kesehatan pada ibu hamil melalui media E-Booklet tentang pencegahan stunting. Kegiatan pengabdian dilaksanakan di Desa Kadirejo, Kecamatan Pabelan, Kabupaten Semarang pada bulan Maret-April 2023. Bentuk kegiatan yang  dilakukan, mengumpulkan seluruh ibu hamil dalam whatshapp group untuk diberikan edukasi kesehatan dengan E-Booklet yang telah disusun oleh tim, diskusi dan tanya jawab, kuis, dan pemberian reward bagi ibu hamil. Pengabdian dilaksanakan pada 15 ibu hamil. Hasil menunjukkan bahwa, setelah diberikan edukasi kesehatan, terdapat peningkatan pengetahuan ibu hamil tentang pencegahan stunting melalui pemberian E-Booklet.
Projected changes in land carbon store over the 21st century: what contributions from land-use change and atmospheric nitrogen deposition?
Authors: Riano Sanchez Jaime Andres , Vuichard Nicolas , Peylin Philippe
Published: November 2023

Abstract. Earth System Models (ESM) represent the time evolution of the biophysical (energy, water cycles) and biogeochemical (carbon cycle) components of the Earth. When used for near-future projections in the context of the Coupled Model Intercomparison Project (CMIP), they use as forcings the evolution of greenhouse gas and other pollutant concentrations and land-use changes simulated by an ensemble of Integrated Assessment Models (IAMs) for a combination of socio-economic pathways and mitigation targets (SSPs). More precisely, only one IAM output is used as representative of a single SSP while the inter-IAM spread is large for ammonia emissions and land-use changes, for instance. This makes the comparison of key ESM diagnostics among SSPs significantly noisy, without the capacity of disentangling SSP-driven and IAM-driven factors. In this paper, we quantify the projected change in land carbon store (CLCS) for the different SSPs with an advanced version of a land surface model embedded into IPSL-CM6 ESM. Through a set of land-only factorial simulations, we specifically aim at estimating the CLCS uncertainties associated with land-use change and nitrogen deposition trajectories. We showed that the spread of the simulated change in global land carbon store induced by the uncertainty on land-use changes is slightly larger than the one associated with the uncertainty on atmospheric CO2. Globally, uncertainty associated with N depositions is responsible for a spread in CLCS lower by a factor three, than the one driven by atmospheric CO2 or land-use changes. Our study calls for making available additional IAM scenarios for each SSP to be used in the next CMIP exercise, in order to specifically assess the IAM-related uncertainty impacts on the carbon cycle and the climate system.
Pseudo-Chilblains in Adult Patients with Confirmed COVID-19: A Systematic Review
Authors: Hayles Seon , Williams Kelsey , Thomas Nidhi , Morgan Jabari , Braham Donna , Gossell Williams Maxine , Ho Jonathan D.
Published: November 2023

Background: Pseudo-chilblains have been associated with COVID-19. Many reports, however, lack confirmation of COVID-19 infection. While likely associated, all chilblains/chilblain-like lesions during this time should not be assumed to be COVID-19 related. This study examines the characteristics of adults with pseudo-chilblains and confirmed COVID-19.
Methods: A systematic review of PubMed/MEDLINE database was performed using the PRISMA guidelines. Adults (>18 years) with confirmed COVID-19 were included. De-identified registries were excluded to avoid duplication. We extracted study design, age, sex, race, geographic location, relationship of COVID-19 diagnosis to chilblains onset, confirmatory testing, hospitalization status, anatomical location, cold/damp exposure, presence/absence/description of pseudo-chilblains symptoms, presence/absence of biopsies/histopathologic findings, tissue IHC/PCR, presence/absence/details of extracutaneous COVID-19 disease, pre-existing chilblains, treatment and resolution timeline. The search was completed in July 2022.
Results: We identified 13 studies (29 patients). In COVID-19-infected adults, pseudo-chilblains were reported primarily from North America and Europe, occurring in both sexes over a wide age-range, affected well and ill patients, favored the hands and feet and could be symptomatic or asymptomatic. Most patients had extracutaneous symptoms. Resolution time ranged from <1 week to >50 days. There was marked variation in treatment strategies and appearance of pseudo-chilblains relative to entire disease course. Biopsies were infrequently performed but findings similar to classical chilblains were described.
Conclusions: Many patients reported as pseudo-chilblains of COVID-19 lack confirmed infection. Infection confirmation, photographic documentation and histopathology are critical to establish homogeneity in reported pseudo-chilblains during this global pandemic. Further work clarifying the relationship of acral eruptions and COVID-19 is necessary.
Początki Akademii Wileńskiej (1569-1600)
Authors: Piechnik Ludwik
Published: November 2023

Przedmiotem niniejszej pracy jest zaprezentowanie początków Akademii Wileńskiej przede wszystkim w oparciu o źródła Rzymskiego Archiwum Towarzystwa Jezusowego dotychczas nie wykorzystanego przez historyków. Wyczerpująco zostało przedstawione stopniowe rodzenie się uczelni wileńskiej począwszy od prywatnych lekcji udzielanych krewnym biskupa, poprzez otwarcie kolegium, utworzenie wydziału filozoficznego i teologicznego, aż do erekcji uniwersytetu. Obszernie również zostało omówione zagadnienie profesorów. W pracy wyraźnie podkreślono ścisłe związki między scholastyką wileńską a scholastyką hiszpańską. Do artykułu dołączono dokumenty, które mają istotne znaczenie dla poznania najstarszych dziejów Akademii Wileńskiej oraz szkolnictwa jezuickiego w XVI wieku.
Inovações expressivas no cancioneiro de amigo do trovador Joam Soares Coelho
Authors: Correia Ângela
Published: November 2023

Este artigo ocupa-se da interpretação de algumas inovações com que o trovador português do séc. XIII, Joam Soares Coelho, marca o tecido verbal das suas cantigas de amigo, surpreendendo o público. Trata-se de expressões muito pouco ou nada usadas na lírica galego-portuguesa, como «tan cruamente o vedar», «meter en ventura», «saia per u Deus quiser», «ter en coita».
Bladder jackstone induced by prostate cancer
Authors:   Galilee Medical Center, Nahariya 22100, Israel., Zbidat Mohamad
Published: November 2023

A 73- years-old man was referred to emergency department with bilateral flank pain and new-onset hematuria. He had a history of prostatic cancer and recurrent urinary tract infections
Megalencephalic leucoencephalopathy with subcortical cysts: A cause of early seizures after trivial head trauma
Authors:   Unit of Neurology, IRCCS Istituto delle Scienze Neurologiche Via Altura, 3 Bologna, Italy, Pasini Elena
Published: November 2023

Megalencephalic Leucoencephalopathy with subcortical Cysts (MLC) is a rare autosomal recessive disease with onset in infancy. Typically, the first symptom is macrocephaly which becomes evident in the first year of life [1-3].
Art for Advanced Radiation Oncology – Synchronizing the Past and the Future for a Better Patient Care
Authors:   Clinical Development Department, MVision AI, Helsinki, Finland, Chirilă Monica-Emilia , Gambacorta Maria Antonietta ,   Università Cattolica del Sacro Cuore, Radiation Oncology Department, Rome, Italy
Published: November 2023

"Professor Maria Antonietta Gambacorta is a specialist in Radiation Oncology with a PhD in Brachytherapy. She is responsible for the Radiotherapy Oncology hospitalizations and the Interventional Oncology Center and the coordinator of the Multidisciplinary Group for the treatment of rectal tumors within the Comprehensive Cancer Centre of the Fondazione Policlinico Agostino Gemelli, Rome. Due to her level of expertise, she was elected member of the Board of Directors of the Italian Association of Radiation Oncology (AIRO); and member of the board for the drafting of the Guidelines on rectal cancer of the Italian Association of Medical Oncology. Professor Gambacorta is a member of European Society of Radiation Oncology (ESTRO) where she carries out teaching activities in international courses of the ESTRO school. She has published more than 170 scientific publications in peer-reviewed journals, including the International consensus guidelines for Clinical Target Volume delineation in rectal cancer. In this interview, Professor Gambacorta shares some insights about the Art for ART project, implemented in the Radiotherapy department of Policinico Agostino Gemelli, Rome."