bluuebunny/crossref_metadata_2025 huggingface dataset:
Generalizing Productivity and Service Stake. A Heterodox Widened Approach
Authors: Jivan Alexandru , Năchescu Miruna-Lucia
Published: February 2020

The aim of the present paper is to put together, point out and underline the core characteristics of a generalized concept of productivity built on a heterodox outlook. The analysis is conducted under the assumption that the developing knowledge in nowadays society and the concern for basing the economy on it require a reviewed approach on productivity. Relevant moments from the economic thought and literature are invoked(certain approaches on productivity from the most representative Romanian economic thought here included); the research finds reason and main conceptual grounds in the genuine liberalism and in the service economy, by a critical view on the concern for productivity growth as commonly seen and calculated. The paper also aims to bring to the current attention some pioneer work, less known but very important for the productivity mark. The paper develops the service stake as defining value creation and reveals the most important differences between common productivity (usually calculated productivity) and the new approach that takes into account the generalized service approach consistent with nowadays society.

This paper is a theoretical presentation designed to serve as an improved context for reconsidering the researches focused on – or connected with – productivity.
Theoretical and Methodological Context of (Post)-Modern Econometrics and Competing Philosophical Discourses for Policy Prescription
Authors: Jackson Emerson Abraham
Published: February 2020

This research article was championed as a way of providing discourses pertaining to the concept of “Critical Realism (CR)” approach, which is amongst many other forms of competing postmodern philosophical concepts for the engagement of dialogical discourses in the area of established econometric methodologies for effective policy prescription in the economic science discipline. On the whole, there is no doubt surrounding the value of empirical endeavours in econometrics to address real world economic problems, but equally so, the heavy weighted use and reliance on mathematical contents as a way of justifying its scientific base seemed to be losing traction on the intended focus of economics when it comes to confronting real world problems in the domain of social interaction. In this vein, the construction of mixed methods discourse(s), which favour that of CR philosophy is hereby suggested in this article as a way forward in confronting with issues raised by critics of mainstream economics and other professionals in the postmodern era.
Comparison of strain and dyssynchrony measurements in fetal two-dimensional speckle tracking echocardiography using Philips and TomTec
Authors: Köster Helen Ann , Hammer Kerstin , Braun Janina , Oelmeier de Murcia Kathrin , Möllers Mareike , Klockenbusch Walter , Schmitz Ralf
Published: February 2020

Background

The aim of this study was to compare Philips and TomTec two-dimensional speckle tracking echocardiography (2D-STE) software measurements of strain and dyssynchrony values in healthy fetuses.

Methods

This was an explorative observational study in which the echocardiographic data of 93 healthy fetuses between the 20thand 38thweek of gestation were determined from a four-chamber view using 2D speckle tracking. The global and segmental longitudinal strain values of both ventricles, inter-ventricular and left intra-ventricular dyssynchrony were analyzed using QLab version 10.8 (Philips Medical Systems, Andover, MA, USA) and TomTec-Arena version 2.30 (TomTec, Unterschleißheim, Germany).

Results

TomTec showed persistently lower values for all of the assessed strain and dyssynchrony variables. For all variables, the bias between vendors tended to increase with gestational age, though not to a significant extent. Left ventricular dyssynchrony and longitudinal strain within the mid segment of the septum correlated best between vendors; however, the limits of agreement were wide in both cases. None of the variables assessed in the two-chamber view compared well between QLAB and TomTec.

Conclusion

Speckle tracking software cannot be used interchangeably between vendors. Further investigations are necessary to standardize fetal 2D-STE.
Photonic spin Hall effect on the surfaces of type-I and type-II Weyl semimetals
Authors: Jia Guang Yi , Huang Zhen Xian , Ma Qiao Yun , Li Geng
Published: February 2020

Topological optics is an emerging research area in which various topological and geometrical ideas are being proposed to design and manipulate the behaviors of photons. Here, the photonic spin Hall effect on the surfaces of topological Weyl semimetal (WSM) films was studied. Our results show that the spin-dependent splitting (i.e. photonic spin Hall shifts) induced by the spin-orbit interaction is little sensitive to the tilt αt
of Weyl nodes and the chemical potential μ in type-I WSM film. In contrast, photonic spin Hall shifts in both the in-plane and transverse directions present versatile dependent behaviors on the αt
and μ in type-II WSM film. In particular, the largest in-plane and transverse spin Hall shifts appear at the tilts between −2 and −3, which are ~40 and ~10 times of the incident wavelength, respectively. Nevertheless, the largest spin Hall shifts for type-II WSM film with positive αt
are only several times of incident wavelength. Moreover, the photonic spin Hall shifts also exhibit different variation trends with decreasing the chemical potential for different signs of αt
in type-II WSM films. This dependence of photonic spin Hall shifts on tilt orientation in type-II WSM films has been explained by time-reversal-symmetry-breaking Hall conductivities in WSMs.
Monolayer MoS2 for nanoscale photonics
Authors: Yang Xianguang , Li Baojun
Published: February 2020

Transition metal dichalcogenides are two-dimensional semiconductors with strong in-plane covalent and weak out-of-plane interactions, resulting in exfoliation into monolayers with atomically thin thickness. This creates a new era for the exploration of two-dimensional physics and device applications. Among them, MoS2 is stable in air and easily available from molybdenite, showing tunable band-gaps in the visible and near-infrared waveband and strong light-matter interactions due to the planar exciton confinement effect. In the single-layer limit, monolayer MoS2 exhibits direct band-gaps and bound excitons, which are fundamentally intriguing for achieving the nanophotonic and optoelectronic applications. In this review, we start from the characterization of monolayer MoS2 in our group and understand the exciton modes, then explore thermal excitons and band renormalization in monolayer MoS2. For nanophotonic applications, the recent progress of nanoscale laser source, exciton-plasmon coupling, photoluminescence manipulation, and the MoS2 integration with nanowires or metasurfaces are overviewed. Because of the benefits brought by the unique electronic and mechanical properties, we also introduce the state of the art of the optoelectronic applications, including photoelectric memory, excitonic transistor, flexible photodetector, and solar cell. The critical applications focused on in this review indicate that MoS2 is a promising material for nanophotonics and optoelectronics.
Three new amidophosphoric acid esters with a P(O)[OCH2C(CH3)2CH2O] segment: X-ray diffraction, DFT, AIM and Hirshfeld surface investigations of bi- and tri-furcated (three and four-center) hydrogen bond interactions
Authors: Bozorgvar Marjan Sadat , Tarahhomi Atekeh , van der Lee Arie
Published: February 2020

Structural and packing features of three new amidophosphoric acid esters having a common partXP(O)[OCH2C(CH3)2CH2O], withX = [(CH3)3CNH] (1), [(CH3)2HCNH] (2) and [C6H11(CH3)N] (3), are investigated by single crystal X-ray diffraction. The results illustrate that the compounds1and3crystallize with one independent molecule in the asymmetric unit; whereas, for2, the compound crystallizes with three independent molecules in the asymmetric unit. The crystal structures are mostly stabilizedviatri-furcated hydrogen bond interactions (C–H · · ·)2(N–H · · ·)O=P in1and (C–H · · ·)3O=P in3, while the stability is given by bi-furcated hydrogen bond interactions (C–H · · ·)(N–H · · ·)O=P in2. For a better understanding of the nature, strength and energetics associated with the formation of the quoted multi-center hydrogen bond interactions, the Natural Bond Order (NBO) method from Density Functional Theory (DFT) and a topological analysis by means of Atoms In Molecules (AIM) and Hirshfeld surface procedures were performed. These studies reveal that the studied multi-center hydrogen bond interactions of the type O · · · H are favoured in the crystal packing displaying enrichment ratios larger than unity. The detailed nature of the different interactions in these multi-center interactions is studied for the first time in such compounds. It is shown that the N–H · · · O interaction is rather non-covalent closed-shell whereas the C–H · · · O interaction is more van der Waals closed-shell. Stronger hydrogen bond interactions are observed for a lower multiple H-atom acceptor oxygen in three-center hydrogen bond interactions (C–H · · ·)(N–H · · ·)O=P of2than for four-center interactions in1[i.e. (C–H · · ·)2(N–H · · ·)O=P] and3[i.e. (C–H · · ·)3O=P]. The better H-atom acceptability of the O atom of P=O compared with the esteric O atom is explained by the richers-character of the hybrid orbital of the O atom acceptor of P=O coupled with enhance of the polarization and charge. The obtained results are also confirmed by Molecular Electrostatic Potential (MEP).
Evaluation of genetic diversity and relationships among eight Russian and Ukrainian cattle breeds based on microsatellite markers
Authors: Snegin E. A. , Kramarenko A. S. , Snegina E. A. , Kramarenko S. S.
Published: February 2020

In recent years, special attention has been paid both to the preservation of the genetic diversity of cattle breeds in the Russian Federation and Ukraine, and to the evaluation of the breeds’ ‘purity’, especially in relation to undesirable recessive lethal mutations. The main goal of our work was to assess the genetic diversity of the main cattle breeds bred in the Russian Federation and Ukraine using microsatellite DNA loci, as well as to evaluate the phylogenetic relationships between them. An analysis of molecular genetic diversity was carried out in different cattle breeds represented both in the Russian Federation and Ukraine. A total of 752 individuals, which belonged to eight breeds of the dairy and meat productivity directions were studied. Ten microsatellite loci recommended by ISAG-FAO and arranged in one multiplex panel (ETH3, INRA023, TGLA227, BM1818, TGLA122, SPS115, TGLA53, BM2113, BM1824 and ETH10) were used as DNA markers. Some alleles were found with a very high frequency in most of the studied cattle breeds and, thus, they can be considered as species-specific for the species Bos taurus as a whole. These were alleles 262 and 266 bp (for BM1818), 180 and 188 bp (for BM1824), 125-127 and 133-135 bp (for BM2113), 217-219 bp (for ETH10), 248 and 252 bp (for SPS115). All breeds included in the analysis are characterized by a very high genetic uniqueness based on microsatellite loci; the accuracy of assigning the studied individuals to their own population varied within the range of 95–100%. In general, all breeds studied are grouped into two clusters. Cluster No. 1 contains genetic groups originating from Holstein, and cluster No. 2 contains the remaining breeds. Three breeds (Ayrshire, Simmental and Russian Red Pied) are characterized by very low estimates of the effective population size (less than 50 animals), which may lead to the loss of their genetic uniqueness in the future. In the study of eight dairy and meat cattle breeds that are bred in the Russian Federation and Ukraine, we found that the breeds differ significantly in the genetic polymorphism indicators over ten MS-DNA loci used. Moreover, the level of allelic diversity for the studied breeds was determined, primarily, by the presence and number of rare (and/or “private”) alleles. This may be due to the manifestation of different mechanisms of the formation and maintenance of genetic polymorphism in breeds, based on productivity direction.
Microscopic changes in the digestive organs of domestic canaries poisoned with canthaxanthin
Authors: Serdioucov J. K. , Zabudskyi S. M. , Kruchynenko O. V. , Mykhailiutenko S. M.
Published: February 2020

Intoxication of canaries with canthaxanthin has been recorded more and more often since the late 1990s. This problem is related to active use of this substance for changing or increasing the colouration of this species of bird. For determining morphological changes during canthaxanthin toxicosis, we formed one control and three experimental groups of domestic canaries, which were given canthaxanthin in different doses. The material for microscopic surveys was isolated from the digestive organs of the examined birds; from this material, histological sections were prepared and stained with hematoxylin and eosin. According to the results of microscopic analysis, we determined that the intoxication of the organism of canaries with canthaxanthin causes a certain complex of changes at the tissue level. We found that canthaxanthin intoxication leads to chronic pathological processes in the digestive organs, both the digestive canal and digestive glands (pancreas, liver). In the organs of the digestive tract (glandular stomach or proventriculus, muscular stomach or gizzard, and the intestine) we found chronic catarrhal inflammation, and also proliferative processes – cellular infiltration of the stroma, overgrowth of the connective tissue. In some cases we also found distrophic processes such as keratinization of the epithelium of the mucous membrane of the glandular stomach. In the pancreas, except for edema of the stroma, no pathological processes were observed. In the liver, we found different types of dystrophy – protein (granular, hydropic) and fatty (infiltrational). With introduction of the highest doses of canthaxanthin used in the experiment, we determined a tendency towards exacerbation of pathological processes, because, apart from the already mentioned changes, we recorded manifestations of alteration (necrotic processes, disorders in blood circulation). Therefore, we proved that irrational use of canthaxanthin in canary-keeping is a factor that can negatively influence the health of these animals. Using the data we obtained, use of canthaxanthin in the diet of canaries can be correlated with their diet, thus avoiding risk of bird diseases. There is scope for further studies on the impact of canthaxanthin on other organs and the systems of the organs at microscopic level, as well as conducting biochemical and morphological analyses of blood, which would allow the creation of a new complete clinical-anatomical description of this pathology.
Assessment of phenotypic and storage protein diversity in exotic barley cultivated in District Dir (Pakistan)
Authors: Ali M. , Nisar M. , Khan W. , Naz T. , Zaman S. U. , Hussain M.
Published: February 2020

A total of 198 exotic barley genotypes were collected from the Gene Bank of the Plant Genetic Resource Institute (PGRI), National Agriculture Research Center (NARC), Islamabad, Pakistan, for the assessment of genetic diversity based on morphological and seed storage proteins. Qualitative and quantitative traits were noted as per IPGRI, 1994 descriptor. Among the quantitative parameters, a high level of genetic variability index was noted in seeds per spike at 79.9% of coefficient of variance followed by biomass per plant which shows 37.4% variance, while minimum variance in quantitative traits was noted in days to germination at 5.4% followed by days to maturity at 3.1% with average mean genetic variation in all quantitative traits at 97.6%. Assay of total seed protein in these exotic accessions was analogue through polyacrylamide gel electrophoresis. A high level of variation was noted in loci (bands) B26 (0.98%) followed by B25 (0.89%), B24 (0.78%),B23 (0.69%) and B01 (0.52%). A similarly low level of variation was detected in B03 (0.16%) followed by B06 (0.18%), B13 (0.19%), B12 (0.21%), B11 (0.23%), B05 (0.24%), B07 (0.25%), B21 (0.34%), B20 (0.35%), B17 (0.39%). The results indicate that the mean value of variation in these accessions is 97.6%. Further assessments and exploration were suggested for these genotypes in multi-climatic zones to satisfy farmers’ need, breeders’ interest and malt-industrial requirements.
Effects of drought at different periods of wheat development on the leaf photosynthetic apparatus and productivity
Authors: Morgun V. V. , Stasik O. O. , Kiriziy D. A. , Sokolovska-Sergiienko O. G. , Makharynska N. M.
Published: February 2020

The problem of drought impact on crop productivity is especially relevant for the leading cereal – wheat, since significant cultivation areas of this crop are located in risky farming zones. The aim of our studies was to compare the peculiarities of drought impact during the period of vegetative growth and reproductive development on the chlorophyll content, activity of chloroplast antioxidant enzymes, the rate of carbon dioxide gas exchange and transpiration as well as productivity of the wheat plants. The studies were carried out on bread winter wheat plants (Triticum aestivum L.) of the Astarta and Natalka varieties grown in a pot experiment. The plants were watered daily to maintain the soil moisture level in the pots in the range 70–60% of field capacity. Drought treatment involving decrease in soil moisture to 30% of the field capacity was applied to some of the plants at late stem elongation stage (BBCH 37-45) and to other plants at heading-anthesis (BBCH 59-65) while control plants were watered as usual. After 7 days of drought, the watering of treated plants was resumed to maintain the soil moisture at the level of control plants until the harvest. The penultimate leaf at the late stem elongation stage and flag leaf at the heading–anthesis period were used for measurements of photosynthetic apparatus response to drought. Plants of both varieties treated at stem elongation stage showed lower decline in the photosynthetic activity, chlorophyll content and grain productivity than those treated at heading-anthesis. The results obtained indicated that photosynthetic apparatus of wheat has a higher drought tolerance at the stem elongation stage than during the heading-anthesis stage. Furthermore, plants stressed at the stem elongation stage revealed better compensatory growth of lateral productive shoots due to superior supply of plants with assimilates after drought termination. Astarta variety had a more drought-tolerant photosynthetic apparatus and higher grain productivity in both well-watered and drought conditions as compared to Natalka variety. The differences between varieties were more contrasting when drought was applied at heading-anthesis.
Peculiarities of microstructure of the suprarenal glands of rabbits with different types of autonomic tone
Authors: Zakrevska M. V. , Tybinka A. M.
Published: February 2020

The article investigates the structure of the suprarenal (adrenal) glands of male rabbits (Oryctolagus cuniculus), in which, on the basis of electrocardiographic and variational-pulsometric studies, different types of autonomic tone were observed. This allowed the animals to be divided into three groups: 1) sympathicotonic rabbits; 2) normotonic rabbits; 3) parasympathicotonic rabbits. The animals of the first two groups were characterized by almost the same body weight, while weight of the rabbits of the third group was slightly higher. After euthanasia, the suprarenal glands were extracted for histological and histochemical analyses. Morphometric study of histopreparations revealed that in the normotonic rabbits the thickness of the zona glomerulosa and zona fasciculata of the suprarenal glands were of average sizes, and the area of the medulla was the smallest. The parasympathicotonic rabbits had the thickest zona glomerulosa and greatest area of the medulla, but the thinnest zona fasciculata. The sympathicotonic rabbits were observed to have the greatest thickness of the zona fasciculata of the suprarenal glands, the area of the medulla was of average values, and the thickness of the zona glumerulosa was of minimum value. The type of autonomic tone also manifests in the saturation of each of the zones with cells. The normotonic rabbits were observed to have the highest number of cells per area of 1,000 µm² in the zona fasciculata and the medulla, sympathicotonic rabbits – in the zona glomerulosa and zona reticularis, and in parasympathicotonic rabbits this parameter had average or lowest values in all the zones. The sizes of cells and their structural parts were characterized on the basis of nuclear-cytoplasmic ratio. In the zona fasciculata and medulla this parameter was highest among parasympathicotonic rabbits, and lowest in sympathicotonic rabbits. In the zona glomerulosa, almost equal values were observed in the normotonic and parasympathicotonic rabbits, while being reliably lower in sympathicotonic rabbits. By the value of nuclear-cytoplasmic ratio in the zona reticularis, the normotonic rabbits dominated, followed by the sympathicotonic animals, and the parasympathicotonic rabbits had the lowest parameters.
Synergistic activity of filtrates of Lactobacillus rhamnosus and Saccharomyces boulardii and antibacterial preparations against Corynebacterium spp.
Authors: Isayenko O. Y.
Published: February 2020

We present the results of the first study of the combined influence of the biologically active substances Lactobacillus rhamnosus GG ATCC 53103 and Saccharomyces boulardii, obtained by the author’s method, and antibacterial agents on Corynebacterium spp. The first area of research was the study of increasing the sensitivity of toxigenic microorganisms to antimicrobial drugs due to the consecutive effects of the structural components and metabolites of L. rhamnosus GG and S. boulardii and antibacterial drugs on Corynebacterium spp. tox+. The greatest increase in the sensitivity of test-cultures of corynebacteria to penicillin (by 19.4 mm), imipenem (by 15.0 mm), vancomycin (by 12.0 mm), gentamicin (by 11.0 mm), ciprofloxacin (by 9.8 mm), erythromycin (by 9.6 mm), cefotaxime (by 9.5 mm) occurred due to the products of lactobacteria and a combination of metabolites of lactobacteria and saccharomycetes. The second area of research was the study of the synergic activity of substances L. rhamnosus GG and S. boulardii and traditional antibacterial drugs manifested by their simultaneous effect on Corynebacterium spp. Maximum potentiation of azithromycin (by 4.6 mm), erythromycin (by 4.5 mm), cefotaxime (by 2.2 mm), ceftriaxone (by 1.6 mm) and ampicillin (by 1.0 mm) relative to corynebacteria was also observed under the influence of lactobacteria metabolites and a combination of lactobacteria and saccharomycetes metabolites. Different degrees of manifestation of the combined action of biologically active substances L. rhamnosus GG and S. boulardii with antibiotics were determined, which depended on the selected combinations, the method of influence on the microorganism, the individual sensitivity of the test-cultures, the activity of the test filtrates and the initial concentration of the producers used to obtain the products of vital activity of lactobacteria and saccharomyces. The presented complexes of structural components and metabolites of L. rhamnosus GG and S. boulardii, obtained without the use of traditional nutrient media, by increasing the bioavailability of pathogenic pathogens can reduce the required concentration of the antibiotic, continuing their use, and suspend the likelihood of pathogens developing resistance to microorganisms. This makes them promising candidates both for the development of "accompaniment-preparations" for antibiotics for the additional therapy of infectious diseases of different etiology, and for the creation of a new direction of antimicrobial agents with multifunctional capabilities. Synergistic activity of filtrates L. rhamnosus GG and S. boulardii and antibacterial preparations against Corynebacterium spp.
Features of Dictamnus albus (Rutaceae) in the pregenerative period of ontogeny in M. M. Gryshko National Botanical Garden in Ukraine
Authors: Gnatiuk А. М.
Published: February 2020

Investigation of plant ontogenetic peculiarities and establishment of boundaries of ontogenetic states of individuals is a necessary basis for studying their populations. The minimal amount of data on morphology of plants in the pregenerative period of ontogenesis complicates plant identification in natural and cultural populations. Such information is especially important for rare species of plants. Dictamnus albus L. is a perennial rare plant listed in the Red Book of Ukraine.The objective of this research is to analyze the peculiarities of ontomorphogenesis of D. albus, to establish diagnostic signs of age stages and the sequence of their passage for identification of the multivariance of development. The results of the study on D. albus ontomorphogeny in the latent and pregenerative period at the M. M. Gryshko National Botanical Garden оf the National Academy of Sciences of Ukraine are represented in this article. Diagnostic features of age stages: seeds, seedlings, juvenile, immature, virginile are established. The study shows a multivariate development that reveals different sequences of passing ontogenesis states by individuals and, accordingly, the rate of their aging and life expectancy. To describe the variation of the passage by individuals of ontogeny stages, we divided the stages into ontomorphs, which determined the degree of development-degradation of plants. The research showed that every age stage lasts for one growing season or longer. The first bloom in plants does not come earlier than the sixth year of vegetation. Seedlings and juvenile plants vary in leaf number and phyllotaxy. The development of immature plants takes place from the third year of vegetation. Seedlings, juvenile and young immature plants have a tap-root system. In individuals older than 4 years a root system forms which becomes similar to the fibrous root system due to the presence of several thickened roots. In immature and virginile plants, we observed the formation of adventitious roots on the caudex. It has been found that D. albus is characterized by heterophylly and morphological variability of leaves, which is developed during ontogeny and shoot formation. The variety of the architecture of individuals in the early stages of ontogenesis and the multi-variation of their development indicate the variation of the reaction rate.The data may be used for evaluate age (ontogenetic) structure of D. albus populations.
Experimental study of tropism in cultivated canine coronavirus in the small intestine of puppies
Authors: Goralskii L. , Radzіkhovsky N. , Dyshkant О. , Dunaievska O. , Sokulskiy I.
Published: February 2020

The varying extents of natural disease induced by coronavirus in dogs are not completely clear because the pathogenesis of coronavirus enteritis is not studied sufficiently. In this study, based on the results of clinical, virological, morphological and histochemical studies, we determined the pathogenic role of coronavirus in infected dogs using experimental infection, per os, of isolated canine coronavirus (Nick) with titer of infectious activity equaling 4.8 ± 0.04 lg TCID50/cm, cultivated on heterologous cell cultures. This allowed us to determine, supplement, and generalize the data on pathogenesis of the disease and determine the histological changes in the small intestine, where the initial replication of the pathogen takes place. It was found that lesions and the pattern of the pathomorphological changes (destruction, necrosis and edema of the stroma of the villi, lysis of the cytoplasm, deformation of the enterocyte nuclei) in the small intestine of experimentally infected dogs depend on the development of the pathological process related not only to the changes in histoarchitectonics of the wall of the intestine, but also to tension of the histochemical statics, and obviously the dynamic of the cells (accumulation of the main and acidic proteins in enterocytes’ cytoplasm, hypersecretion of the mucus by goblet cells, decrease of Schiff iodine acid-positive substances in the enterocytes’ cytoplasm, formation of basophilous inclusion bodies), which leads to disorders in metabolic processes in the organism of infected dogs as a response to the virus infection. The examined dogs were found to have morphological changes in the small intestine similar to those in spontaneously infected animals. During the action of coronavirus, the contacts between the enterocytes become damaged, which leads to inhibition of the protective functions of the intestine. At the same time, the pathological process in the experimentally infected animals developed rapidly and had an acute course. Thus, coronavirus enteritis as a separate disease is practically unobserved in field conditions, which makes microscopic survey of the pathogenic impact of the latter on the organism of dogs impossible. Therefore, experimental mono-infection allows a detailed study to be conducted of pathomorphological changes of the initial place of the reproduction of the virus – the small intestine affected by coronavirus enteritis.
Effect of alcohol tincture of Aralia elata on the organism of rats and their gut microbiota against the background of excessive fat diet
Authors: Brygadyrenko V. V. , Lieshchova M. A. , Bilan M. V. , Tishkina N. M. , Horchanok A. V.
Published: February 2020

Pharmacological effects of the medicinal plant Aralia elata (Miq.) Seem. 1868 (Araliaceae) are related to presence of over 150 secondary metabolites, including flavonoids, sterols, polysaccharides, terpenoid saponins and terpenoid acids, though the main biologically active substances of A. elata are saponins and flavonoids. Some clinical tests and experimental studies have proved the influence of A. elata on the organism through increase in physical work capacity, exerting an anti-stress effect against a broad range of harmful factors, including stress from cold, immobilization, ultraviolet radiation and low pressure. The literature also reports the anti-ulcer, anti-secretory, antifungal, anti-tumour, and antimicrobial activity of preparations from this plant. In our laboratory experiment, we determined that ethanolic tincture of A. elata has no effect on the intensity of growth of body weight of young rats against the background of excessive content of fat in their diet. Excessive fat-feeding of male rats leads mostly to disorders in the functioning of the liver and development of steatosis. This was accompanied by reduction in relative mass of the liver, increase in activity of hepatic enzymes, dysproteinemia, increase in the level of bilirubin and decrease in the level of urea. Additional use of 0.1% ethanol led to impaired functioning of the kidneys, reduction of their relative mass, signs of dehydration, increase in the level of creatinine and total calcium in the blood. Use of ethanolic tincture of A. elata mitigates negative excess of fat, is accompanied by normalization of indices of mass of the organs, less notable dysproteinemia, impairment in the level of creatinine, glucose, urea, cholesterol, bilirubin and total calcium. Ethanolic tincture of A. elata has a low immunosuppressive action, against the background of a high fat diet it leads to increase in the amount of typical Escherichia сoli, decrease in Еnterococcus spp. and Enterobacter spp., significant decrease and in high concentrations (0.1% ethanolic tincture of A. elata) elimination of bacteria of Clostridium and Klebsiella genera, and also various yeast fungi in the intestine. In the examined male rats, against the background of excess of fat in the diet, no serious changes in the composition of the normal gut microbiota (Bifidobacterium spp., Lactobacillus spp., Proteus spp., Staphylococcus spp., Candida spp.) was observed, nor were any lactose-negative enterobacteria (Citrobacter genus) found. Perspectives of further research include determining histological, histochemical and immune-histological changes in the organs of laboratory animals under the effect of ethanolic tincture of A. elata following excessive accumulation of fat.
Pathogenetic role of Staphylococcus aureus in purulent keratoconjunctivitis in cats
Authors: Maslikov S. N. , Bely D. D. , Samoiliuk V. V. , Vakulik V. V. , Spitsyna T. L.
Published: February 2020

The research was carried out in the Department of Surgery and Obstetrics of Agricultural Animals of Dnipro State Agrarian and Economic University on clinically healthy outbred cats of different ages with purulent keratoconjunctivitis. Hematological, biochemical and immunological parameters were determined in the animals, and microbiological and virological research was conducted on them. According to the data obtained, more than half of cases of ophthalmopathology in cats were conjunctivitis and keratoconjunctivitis, and they were more often registered in the cold season. The main causes of eye diseases in the cats were mechanical injuries, coccal and chlamydial infection, allergy and development of disease against the background of primary lesions of the ears and paranasal sinuses. Among the detected microorganisms, the vast majority (81.9%) were staphylococci, including S. albus, S. aureus and S. epidermidis. All types of microorganisms except O-forms of Bacillus sp. exhibited high and medium sensitivity to antibiotics. Immunoblotting revealed polypeptides that responded to specific S. aureus antigens in samples of conjunctiva, cornea, intraocular fluid, and blood of cats suffering from purulent (staphylococcal) keratoconjunctivitis. The highest antigen concentration was detected in the cornea and conjunctiva. In the absence of expressive shifts of the investigated hematological and biochemical parameters, the dynamics of immunological markers were shown by a significant increase in the content of immunoglobulins and circulating immune complexes, as well as by a distinct activation of the complement system by the classical route. The results showed a clear gradual activation of phagocytosis, namely: the number of phagocytic neutrophils increased, reaching its maximum value by the seventh day of development of purulent keratoconjunctivitis. The phagocytic index in the first three days of observation tended to decrease, and by the seventh day it had already significantly exceeded the initial value. Despite the ambiguous dynamics of the phagocytic index, in the course of the development of the inflammatory process in the blood of sick cats, we observed a clear increase in the index of complete phagocytosis. Thus, the development of purulent keratoconjunctivitis in cats occurs against the background of clear cellular and humoral responses to the infectious agent.
Fatty acids of lipids of blood serum and liver of rats with tetracyclin-induced hepatosis and at correction
Authors: Gryshchenko V. , Sуsoliatin S. , Midyk S.
Published: February 2020

Irrational pharmacotherapy with tetracyclines can cause mitochondrial cytopathies of liver cells and the development of toxic dystrophy. The issue of violation of the qualitative and quantitative composition of fatty acids and their functional role in the development of liver dystrophy has not been studied enough. Therefore, the aim of the work was to determine the features of changes in the fatty acid composition of blood serum and liver lipids in rats with tetracycline-induced hepatosis and the corrective efficacy of the phospholipid-acceptable dietary supplement “FLP-MD”. It was experimentally established that, in the composition of blood serum lipids and liver tissue, key changes in modeling tetracycline-induced hepatosis in rats (250 mg/kg for 7 days) are primarily tested for polyene fatty acids (PUFAs). In blood serum this is manifested by a decrease in the level of docosadiienoic (22:2ω6) and docosahexaenoic acid (22:6ω3), as well as the total PUFA content due to representatives of the ω3 family, respectively, by 1.3 times. At the same time, a decrease in the content of eicosapentenoic (20:5ω3), docosapentaenoic (22:5ω3), docosahexaenoic (22:6ω3) acids and the saturated/unsaturated fatty acid (SFA/UFA) and ω3/ω6 PUFA ratios, respectively, are noted in the lipid fraction of the liver, respectively by 1.3 times. In contrast to these animals, the use of reparative action of a phospholipid-acceptable dietary supplement “FLP-MD” (13.5 mg/kg) in sick rats provides a significant increase in the level of these fatty acids both in blood serum and in the liver and the restoration of their profile for other representatives. Thus, the components of the “FLP-MD” dietary supplement show a corrective effect on the fatty acid composition of the lipid component of blood serum and liver tissue of animals with tetracycline-induced hepatosis. Indicators have been experimentally established for the diagnosis of toxic liver damage and preclinical trials of the hepatoprotective efficacy of new drugs, which is a promising area of research in veterinary hepatopathology.
Evaluation of effects of selenium nanoparticles on Bacillus subtilis
Authors: Tymoshok N. O. , Kharchuk M. S. , Kaplunenko V. G. , Bityutskyy V. S. , Tsekhmistrenko S. I. , Tsekhmistrenko O. S. , Spivak M. Y. , Melnichenko О. М.
Published: February 2020

The present study was performed to characterize of selenium nanoparticles (Nano-Se) which were synthesized by pulsed laser ablation in liquids to obtain the aqueous selenium citrate solution. The study was conducted using bacteriological and electronic-microscopic methods. Transmission electron microscopy (TEM) and spectroscopy analyses demonstrated that nano-selenium particles obtained by the method of selenium ablation had the size of 4–8 nm. UV-Visible Spectrum colloidal solution Nano-Se exhibited absorption maxima at 210 nm. To clarify some effects of the action of Nano-Se on Bacillus subtilis, we investigated the interaction of Nano-Se with B. subtilis IMV B-7392 before and after incubation with Nano-Se, examining TEM images. It has been shown that exposure to B. subtilis IMV B-7392 in the presence of Nano-Se is accompanied by the rapid uptake of Nano-Se by bacterial culture. TEM analysis found that the electron-dense Nano-Se particles were located in the intracellular spaces of B. subtilis IMV B-7392. That does not lead to changes in cultural and morphological characteristics of B. subtilis IMV B-7392. Using TEM, it has been shown that penetration of nanoparticles in the internal compartments is accompanied with transient porosity of the cell membrane of B. subtilis IMV B-7392 without rupturing it. The effective concentration of Nano-Se 0.2 × 10–3 mg/mL was found to increase the yield of biologically active substances of B. subtilis. In order to create probiotic nano-selenium containing products, the nutrient medium of B. subtilis IMV B-7392 was enriched with Nano-Se at 0.2 × 10–3 mg/mL. It was found that particles Nano-Se are non-toxic to the culture and did not exhibit bactericidal or bacteriostatic effects. The experimentally demonstrated ability of B. subtilis to absorb selenium nanoparticles has opened up the possibility of using Nano-Se as suitable drug carriers.
Update of Hyperbaric Oxygen Therapy in the Management of Chronic Wound
Authors: Albrethen Ibrahim A , Alshehri Turki M , Albraithen Khalid A , Alenezi Abdullah I , Alkahtani Hussein M , Albalawi Ahmad Y
Published: February 2020

Hyperbaric oxygen therapy (HBOT) is a type of therapy for wound management that employs pressurized oxygen, which patients breathe for a set period. The aim is to increase the amount of oxygen in a person's body, which should aid the process of wound healing, which is especially crucial for chronic wounds. Multiple evidence from clinical trials and studies suggest that HBOT is more effective when compared to traditional therapies in treating chronic wounds, and especially when managing wounds that develop as a result of diabetes. Additionally, two studies conducted on rats with diabetes and patients with foot ulcers suggest that HBOT can address these complex cases, which can aid in reducing the amputation risk. This paper reviews evidence, which proves that HBOT is an effective chronic wound management strategy.
A fizikai aktivitás hatása a nem alkoholos eredetű zsírmájra
Authors: Werling Klára , Langó Anikó
Published: February 2020

Absztrakt:

A nem alkoholos eredetű zsírmáj a leggyakoribb májbetegség világszerte.
Kialakulásában szerepet játszik az egészségtelen táplálkozás, a túlzott kalória-
és szénhidrátbevitel, valamint az inaktív életmód. Az egészséges életmódnak, a
fokozott fizikai aktivitásnak jelentős szerepe van a betegek gyógyításában. Több
vizsgálat igazolta, hogy a rendszeres testmozgásnak kedvező hatása van a máj
szövettani eltéréseire, javul az inzulinnal szembeni érzékenység, nő a
lipogenezis, javul a szénhidrát-anyagcsere, csökken a steatosis és a fibrosis. A
testmozgás hatására csökken a visceralis zsírszövet, melynek fontos szerepe van
a májban zajló gyulladásban és kötőszövet-átépülésben. A bélbaktériumok
összetételének változása szintén hozzájárulhat a kedvező szövettani
változásokhoz. Az emberek mindennapi élete sok esetben nem kedvez a rendszeres
fizikai aktivitásnak, sokan nem tudják és nem is akarják ezt elfogadni. A
kezelés első és legfontosabb része a betegek meggyőzése a változtatás
szükségességéről. A megfelelő fizikai aktivitás önmagában, diéta nélkül képes a
májbetegség javítására. Orv Hetil. 2020; 161(6): 203–207.
Jóindulatú pajzsmirigygöbök perkután alkoholinjekciós kezelésének hosszú távú eredményessége. 254 beteg 10 éves követésével szerzett tapasztalatok
Authors: Solymosi Tamás
Published: February 2020

Absztrakt:

Bevezetés és célkitűzés: A perkután etanolinjekciós (PEI)
kezelést ugyan 30 éve alkalmazzák a pajzsmirigy jóindulatú göbeinél, a legalább
5 évet elérő átlagos követési időt felölelő tanulmány pajzsmirigycisztáknál
(PMCI) és autonóm adenomáknál (AUAD) 2-2 akad, míg nem autonóm működésű, szolid
göböknél (NASZ) egy sincs. Munkánkban jóindulatú pajzsmirigygöbök
PEI-kezelésével szerzett hosszú távú tapasztalatainkról számolunk be.
Módszer: 254, legalább 10 éve PEI-kezelt betegnél
vizsgáltuk a kezelés hosszú távú sikerességét. Ennek feltétele, hogy a göb
térfogata az eredeti 50%-a alatt maradjon, AUAD esetében emellett a betegeknek
kezelés nélkül is euthyreoidnak kellett maradniuk. Eredmények:
79 PMCI esetében 79,4%, 100 AUAD-nál 37,1%, 75 NASZ-nél 69,4% volt a sikerességi
arány 10 évvel a PEI után. Az összes sikertelennek bizonyult kezelés 23,3%-ában
csak több mint 5 év követési idő után derült fény a kezelés sikertelenségére. A
göbök térfogata a követési idő végén a kezelés előtti térfogat 29,8%-a lett
PMCI, 39,6%-a NASZ és 48,9%-a AUAD esetében. PMCI esetében szignifikánsan
eredményesebb volt a kezelés idősebbeknél, más paraméter (göbtérfogat, a beadott
alkohol mennyisége, ezek aránya) nem mutatott szignifikáns kapcsolatot az
eredményességgel. Következtetés: Mindhárom jóindulatú göb
esetében az eddigi leghosszabb követési időt felölelő tanulmányunk megerősíti,
hogy AUAD esetében csak kivételes esetekben, PMCI esetében általában ajánlható a
PEI. NASZ esetében a módszernek szintén van létjogosultsága. A PEI hatásossága
az idő előrehaladtával tovább csökken, ami a hosszú távú követés fontosságára
hívja fel a figyelmet. Orv Hetil. 2020; 161(6): 224–231.
Generalization of $z$-ideals in right duo rings
Authors: MASOUDİ-ARANİ Maryam , JAHANİ-NEZHAD Reza
Published: February 2020

The aim of this paper is to generalize the notion of $z$-ideals to arbitrary noncommutative rings. A left (right) ideal $I$ of a ring $R$ is called a left (right) $z$-ideal if $M_a \subseteq I$, for each $a\in I$, where $M_a$ is the intersection of all maximal ideals containing $a$. For every two left ideals $I$ and $J$ of a ring $R$, we call $I$ a left $z_J$-ideal if $M_a \cap J \subseteq I$, for every $a\in I$, whenever $ J \nsubseteq I$ and $I$ is a $z_J$-ideal, we say that $I$ is a left relative $z$-ideal. We characterize the structure of them in right duo rings. It is proved that a duo ring $R$ is von Neumann regular ring if and only if every ideal of $R$ is a $z$-ideal. Also, every one sided ideal of a semisimple right duo ring is a $z$-ideal. We have shown that if $I$ is a left $z_J$-ideal of a $p$-right duo ring, then every minimal prime ideal of $I$ is a left $z_J$-ideal. Moreover, if every proper ideal of a $p$-right duo ring $R$ is a left relative $z$-ideal,then every ideal of $R$ is a $z$-ideal.
New trends in the study of post-transplant acute kidney injury after liver transplantation
Authors: Iljinsky I. M. , Tsirulnikova O. M.
Published: February 2020

Acute kidney injury (AKI) after liver transplantation (LT) is a pressing issue and remains the focus of many researchers. The etiology of AKI is multifactorial, but the main one is ischemia-reperfusion injury to the liver transplant. Numerous preoperative, intraoperative and postoperative risk factors contribute to the development of AKI. The use of standard classifications, such as AKIN, RIFLE and KDIGO, has improved post-transplant AKI diagnosis. However, determination of creatinine levels in the blood enables AKI diagnosis only in the later stages of this syndrome. Therefore, studies are currently underway to find ways of early diagnosis of AKI using biomarkers. Transition to a molecular level not only improves accuracy but also facilitates early diagnosis of AKI. Currently, the diagnostic capabilities of neutrophil gelatinase-associated lipocalin (NGAL) are the most investigated. To date, there are no known measures of preventing post-transplant AKI. Moreover, treatment of this condition cannot be considered satisfactory. Even a mild post-transplant AKI can be fatal. In severe AKI, where renal replacement therapy is used, there is a risk of death in the intensive care unit. More than half of AKI patients develop chronic kidney disease requiring chronic hemodialysis.
Possible use of spermatogonial stem cells in the treatment of male infertility
Authors: Skaletsky N. N. , Skaletskaya G. N. , Sevastianov V. I.
Published: February 2020

Spermatogonial stem cells, which are already present at birth in the testicles, are the progenitors of male gametes. These cells cannot produce mature sperm before puberty due to their dependence on hormonal stimuli. This feature of the reproductive system limits preservation of fertility only to males who can produce an ejaculate. Therefore, the use of cancer treatment which can lead to fertility loss has made sperm cryopreservation a standard practice. Prepubertal cancer boys – who are prescribed chemotherapy that is toxic to their reproductive system – are deprived of this fertility management procedure. This review focuses on the problem of obtaining and preserving spermatogonial stem cells for future transplantation to restore spermatogenesis. Development of these methods is becoming increasingly urgent due to higher survival rates in childhood cancer over the past decades thanks to improvements in diagnosis and effective treatment. Restoring and preserving fertility using spermatogonial stem cells may be the only option for such patients.