bluuebunny/crossref_metadata_2025 huggingface dataset:
Chikungunya fever in the Emilia Romagna region: what is the public health message?
Authors: La Torre Giuseppe , Gliubizzi Maria Daniela , Marano Cinzia , Solimini Angelo G. , Boccia Antonio
Published: June 2024

Introduction Chikungunya virus (CHIKV) is a mosquitoborne alphavirus indigenous to African countries, the Indian Subcontinent, and Southeast Asia, where it causes endemic and epidemic chikungunya (CHIK) fever [1]. Chikungunya infection is transmitted by biting mosquitoes belonging to the genus Aedes. Since the identification of the virus in the 1950s [2] in Africa, transmission to humans has been usually associated with bites of A. aegypti mosquitoes. In recent outbreaks occurring in the South-eastern islands of the Indian Ocean, transmission has also been associated with A. albopictus, also known as the “tiger mosquito.” This species is indigenous to Southeast Asia, the Western Pacific, and the Indian Ocean, but has recently spread to Africa, the Middle East, Europe, and the Americas. [3]. Although tropical forests are considered to be their original habitat, A. aegypti and A. albopictus have developed the capacity to exploit artificial environments [4]. Besides the natural habitat consisting of tree holes filled with water and other small natural pools, they are capable of breeding in any artificial habitat with small reservoirs of stagnant water, such as vases, buckets, tires and other containers found around houses in urban and periurban areas.
Effects of oral intoxication by lead acetate on pituitary-testicular axis in the pubertal rat
Authors: Lamia Hachfi , Mounir Trimèche , Adel Chekir , Abdelhamid Kerkeni , Fadhel Najjar Mohamed , Rachid Sakly
Published: June 2024

Background: The aim of this work is to study the effects of lead on pituitary-testicular axis. It is about a direct toxicity on testicular cells or an indirect toxicity via abnormalities of the hypothalamic-pituitary axis?
Methods: Forty male rats were divided equitably into four groups. One of these groups received tap water containing 0.3% lead acetate for one month. A second group was assigned to the same protocol but the intoxication was conducted for two months. The third and the fourth groups were used as reference. At the end of the experiment, the rats were anaesthetized and blood was collected for the proportioning of the FSH, the LH, testosterone and lead. The testes and epididymides were removed quickly and weighed. For the determination of testosterone in testicular fluids, a cruciate incision was made in the tunica albuginea of each right testis and centrifuged at 54xg for the extraction of interstitial fluid. Thereafter, the seminiferous tubules were extruded and centrifuged at 6000xg to collect seminiferous tubule fluid. The left testis of each animal was cut in two halves, one half was used for the histological examination and the other was suitably treated for the determination of the lead concentration. The epididymides were homogenized in solution containing Triton X-100 and spermatozoa were counted using Malessez cells. The plasma FSH and LH were determined by RIA using reagents from a commercial kit (BioInternational, France), while testosterone was determined by electrochemiluminescence (Elecsys, rochediagnostics). The lead concentration in blood and Tissues was measured by flameless atomic absorption spectrophotometry with the Zeeman effect background (Hitachi Z- 9000).
Results: In the rats poisoned for one month, no notable effect was noted in spite of a blood lead concentration of 0.721 μg/ml. On the contrary, in animals exposed to lead acetate for two months, the blood level passed to 2.721 μg/ml and plasma testosterone, FSH and LH dropped by about 45%. In parallel, the secretion of testosterone by the Leydig cells fell by 35% and epididymal sperm count dropped by 14%. The histological examination showed lead deposits in the walls of the seminiferous tubules.
Conclusions: Although we do not exclude a directly toxic action of lead on the interstitial cells and on the Sertoli cells, it seems that the hypothalamic-pituitary axis is the major target of lead since the decrease in the plasmatic LH and FSH was associated with a reduction in testosterone secretion and with a reduction in the number of the epididymal spermatozoa
The Decalogue on the future of Public Health in Europe
Authors: La Torre Giuseppe , Fadda Giovanni , Fara Gaetano Maria , Gasparini Roberto , Panà Augusto , Ricciardi Walter
Published: June 2024

The following initiative is being made available to a wider national audience via the document entitled "10 Statements on the Future of Public Health in Europe". This document has been published in several European editions in their respective local languages. The aim of the 10 Statements is to allow a national audience to share the findings of a process of discussions, cultural and scientific exchanges. This process, focusing on the future of public health, began in 2002 within the European Public Health Association (EUPHA). EUPHA is an organization comprised of various public health associations in Europe. EUPHA currently consists of 48 members from 38 different nations and has the participation of more than 10,000 Public Health experts in Europe. This national society network is a tool that helps expand general knowledge about public health problems in Europe, as well as providing an analysis of the different policies and strategies adopted by different countries to address these problems. The Decalogue on the Future of Public Health in Europe is offered simultaneously in English and in Italian on the following journals of Hygiene and Public Health: Annals of Hygiene, Preventive Medicine and Community; - Modern Hygiene - Hygiene and Public Health, - Journal of Preventive Medicine and Hygiene - Italian Journal of Public Health.
Life expectancy: complex measures of the length and the health related quality of life
Authors: Egidi Viviana , Spizzichino Daniele
Published: June 2024

Background: Life expectancy is one of the most frequently used indicators to assess mortality and the healthof a population. It is a synthetic measure of mortality, which has the advantage of allowing for comparisonsover time and between different groups, while eliminating the influence of the age structure of the population.Life expectancy has the advantage of being very easy to understand, although it needs to be interpretedwithin the context of the complex system of hypothesis that generates it. This is even more important forhealth expectancies and health gap measures, which are synthetic indicators that take into account bothsurvival and health condition of a population.Methods: It is given a description of the most frequently used methods to calculate life expectancy, healthexpectancies and health gap measures. Measures of health expectancy are disability free life expectancy andhealthy life expectancy. As health gap measures, frequently are used DALYs (Disability Adjusted Life Years).Discussion: There are various bodies and central government agencies that either have management data orcarry out statistical systematic surveys and disability surveys. Statistically speaking, the worst aspect of thisscenario is that it creates confusion and uncertainty among the end users of this data, namely the policy makers.At an international level the statistical data on disability is scarcely comparable among countries, despite hugeefforts on the part of international organisations to harmonize classifications and definitions of disability.Results and Conclusions: There are several methods to compute life expectancy, each of these has someadvantages and some disadvantages. Usually life expectancy is used also to account for the health status ofpopulation. Actually with the growing role of chronic and degenerative diseases, the increased number ofyears lived are potentially independent from increase in health status of the population. Quantity and qualityof live are not anymore strictly related, then a higher quantity of life does not equate to a better quality of life.For this reason are used health expectancies measures that are very useful morbidity-mortality indicatorsable to summarize information on quantity and quality of the years lived
Is there a relationship between health care models and their performance assessment? The results of an extensive review
Authors: Pelone Ferruccio , De Belvis Antonio Giulio , Volpe Massimo , Ricciardi Walter
Published: June 2024

Background: Health system performance is a multi-dimensional concept related to the achievement of severalobjectives such as effectiveness, efficiency and equity. The aim of this study is to investigate the relationshipbetween models of health care systems (Beveridge, Bismarck and voluntary health insurance) andperformance frameworks available in the scientific literature.Methods: An extensive literature search in several electronic databases was carried out. According to apreliminary classification of performance domains and dimensions, we analysed, among the selected articles,the relationship between domains/dimensions and the three main models of health care systems.Results:12.6% of the children were obese and 26.3% overweight, with the percentage of obesity nearly double inthose who do not practice organized sports activities at least once a week, in those who don’t have breakfastin the morning and in those who don’t spend their free time in movement games.From a multiple logistic regression it results that the risk of being obese is twice and three times higher forthe children living respectively in medium and small towns than for the ones living in large towns.Results: From 540 references found, 17 papers were considered relevant for the purposes of this research.A total of 39 frameworks were identified: 41% referred to the “Beveridge model, 10% to the “Bismarck model”,and 23% to the “Voluntary health insurance” model and 26% to “Umbrella organizations” (e.g. OECD).Domains of effectiveness and responsiveness were covered by all of the frameworks while fewer coveredequity and efficiency.The most frequent dimensions in all the models were effectiveness and technical efficiency, but relevantdifferences exist among the healthcare system models about dimensions of performance considered.Conclusions: Although the need of evaluate health care systems performance is recognized, there is notagreement on what concepts and dimensions of performance should be measured. Our study underlines aninteresting link between the domains/dimensions of performance assessment and models of health care systems
Focus on the activity of local ethic committees in Italy
Authors: Barbadoro Pamela , Frascarello Massimo , Fanesi Marco , Prospero Emilia , D’Errico Marcello Mario
Published: June 2024

Background: The continuing evolution of medical treatments and the loss of neutrality of medicine withrespect to morality of human values have represented the major tracking elements towards settings ofsharing of choices between society and medicine. Several concerns have been raised upon links betweenpharmaceutical corporations and researchers. Moreover, being in a learning environment, we must pay evenmore attention to these items because students appear to be at risk for unrecognized influence by marketingefforts. The aim of this study is to focus on the activities of a local ethics committee (LEC) and thecharacteristics of the protocols discussed in an Italian LEC during a three year period (2001-2003).Methods: Three years of activity of a LEC were analysed by a questionnaire registering: main sponsorship,setting, technical characteristics of trials, outcome of the submission to the LEC, state of progress. Approvedtrials were followed-up until April 30th, 2005.Results: A total of 345 protocols were discussed. 67.8% (n = 198) of approved protocols were submitted by apharmaceutical corporation. 72.6% (n = 212) of studies approved in 2001 were still in progress in 2005. 91.3%(n = 73) of closed trials had a pharmaceutical corporation as their main sponsor. None of the submittedstudies focused on prevention strategies.Conclusions: These results show how important grants offered by pharmaceutical industries are, the effortsspent on therapy and the lack of investors in prevention.
Public health genomics – Relevance of genomics for individual health information management, health policy development and effective health services
Authors: Brand Angela , Brand Helmut
Published: June 2024

Healthcare delivery systems are facing fundamental challenges. New ways of organising theses systemsbased on the different needs of stakeholders’ are required to meet these challenges.While medicine is currently undergoing remarkable developments from its morphological and phenotypeorientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction,the discussion about the relevance of genome-based information and technologies for the health caresystem as a whole and especially for public health is still in its infancy. The following article discusses therelevance of genome-based information and technologies for individual health information management,health policy development and effective health services.
Governance in genomics: a conceptual challenge for public health genomics law
Authors: Schulte in den Bäumen Tobias
Published: June 2024

Increasing levels of genomic knowledge has led to awareness that new governance issues need to be takeninto consideration. While some countries have created new statutory laws in the last 10 years, sciencesupports the idea that genomic data should be treated like other medical data. In this article we discuss thethree core models of governance in medical law on a conceptual level. The three models, the Medical, PublicHealth and Fundamental Rights Model stress different values, or in legal terms serve different principles. TheMedical Model stands for expert knowledge and the standardisation of quality in healthcare. The PublicHealth Model fosters a social point of view as it advocates distribution justice in healthcare and anawareness of healthcare as a broader concept. The Fundamental Rights Model focuses on individual rightssuch as the right to privacy and autonomy. We argue that none of the models can be used in a purist fashionas governance in genomics should enable society and individuals to protect individual rights, to strive for adistribution justice and to ensure the quality of genomic services in one coherent process. Thus, genomicgovernance in genomics requires procedural law and a set of applicable principles. The principle whichunderlies all three models is the principle of medical beneficence. Therefore genomic governance shouldrefer to it as a key principle when conflicting rights of individuals or communities need to be balanced.
Symptom reporting and body-related subjectivity among women and men
Authors: Nykvist Karin , Kjellberg Anders , Bildt Carina
Published: June 2024

The main purpose of this paper is to explore whether there are differences between men and women in bod-ily consciousness, bodily dissatisfaction and state of affect and if these differences contribute to gender dif-ferences in the reporting of symptoms. A questionnaire was sent out to a randomly selected sample of 1500persons, between the ages of 25-55 years in Sweden. The results showed that women in this sample weremore dissatisfied with their bodies, had higher body awareness and scored higher on the measure of nega-tive affect than men. When considering body consciousness and body esteem in combination with negativeaffect, the difference between men and women in symptom reporting was reduced, although a considerablegender difference in symptom reporting remained unexplained.
Public and private in italian health care: trends and market quotas
Authors: Gianino Maria Michela , Russo Roberto , Siliquini Roberta , Icardi Gian Piero , Fora Roberto , Renga Giovanni
Published: June 2024

Background: The Italian healthcare system has two components: public and private healthcare providers.Both deliver services on behalf of and payable by the national health care service. This study explores therelationships between public and private healthcare providers.Methods: The number of hospital admissions and length of stay or number of times the service was accessedstratified by year 2000, 2001, 2002; DRG; type of hospital admission (ordinary or day hospital/surgery); healthprovider category: public institutions without a specific reference territory, public institutions with a specificreference territory and accredited private institutions and medical or surgery DRGs. A distinction is madebetween those DRGs defined as belonging to the private sector and those falling within the public sector,assuming there is a majority market portion for services primarily supplied by the private sector. Case-mixindex was utelised as the indicator for the complexity of the cases treated and the comparative performanceindex was used as the indicator for efficiency. Lastly in order to evaluate the services delivered with aninappropriate organizational profile reference is made the rulings defining Essential Level of assistance.Results: The results showed a shift in the reallocation of service volumes for ordinary admissions towardsthe private sector; the reallocation relates to the volumes but not to the types of cases treated, since the DRGmix remained substantially unchanged over the 3-year period and those DRG that absorb 51% of serviceswere essentially constant. The private sector never achieved a market majority quota but rather controlledmarket niches with minority quotas. The private institutions treated less complex cases and worked withlower efficiency levels than the public sector. There was also a shift in the distribution of admissions fromordinary admissions to day hospital/day surgery regimes with a growth in the proportion of the latter.Conclusions: The study confirmed the predominance of public healthcare providers in the Italian healthcaresystem as well as their higher complexity and efficiency levels.
Evaluating the effect of stress management programmes at the work-site on absenteeism reduction: a systematic review
Authors: Damiani Gianfranco , Federico Bruno , Pinnarelli Luigi , Sammarco Annalisa , Ricciardi Walter
Published: June 2024

Background: In the European Union, work-related stress affects about one in four workers, and it may beresponsible for the loss of productivity, healthcare consumption and absenteeism. The objective of our studywas to estimate whether stress programmes aimed at managing and preventing work-related stress reducedthe rate of absenteeism.Methods: We searched electronic databases for relevant articles assisted by hand searching for references.We included studies that had an experimental or quasi-experimental design, describing an interventionfocused either on the work organisation or on workers’ characteristics as well as reporting a measure ofabsenteeism.Results: The search identified 2520 articles: among these, nine met our inclusion criteria. Stressmanagement programmes reduced absenteeism shortly after the intervention however in the long termthere was no evidence to support this.Conclusion: Future studies should evaluate stress management programmes that consist of repeatedinterventions over longer periods of time, focusing on effectiveness and relative costs.
Public Health Genetics – Challenging “Public Health at the Crossroads”
Authors: Brand Angela , Brand Helmut
Published: June 2024

Dear public health professionals, Honestly, isn’t it time to ask whether or not we are doing “the right things”in public health? Are our present public health strategies evidence-based? The public health agenda demands a vision that reaches beyond research to the application of public health and the determination of it’s impact. In this scenario what is the role of genomics? In the past twenty years, advances in genome research have revolutionised what is known about the role of inheritance in health and disease.[1]
Nowadays,we know that our DNA determines not only the cause of single-gene disorders, but also determines our predisposition to common diseases.Whereas medicine is currently undergoing extraordinary developments from its morphological and phenotype orientation to a molecular and genotype orientation, promoting the importance of prognosis and prediction, public health practice has to date concerned itself with environmental determinants of health and disease and has paid scant attention to genetic variations within the population.
 The advances brought about by genomics is changing these perceptions.[2,3] Many predict, that this knowledge will enable health promotion messages and disease prevention programmes to be specifically directed at susceptible individuals or at subgroups of the population, based on their genetic profile.[4,5]
The new technologies will allow researchers to examine genetic mutations at the functional genomic unit level, and to better understand the significance of environmental factors such as noxious agents, nutrition and personal behaviour in relation to the causation of diseases such as cardiovascular diseases, psychiatric disorders and infectious diseases.
Renewal of Pancasila Based Banking Law in The Framework of Structuring Rural Bank to Face The Challenges of Globalization
Authors: Sinaga Pidari , Yusriyadi  , Silviana Ana
Published: June 2024

Objective: This study aims to analyze the dynamics of the regulation of Rural Credit Banks in Indonesia, the urgency of legal reform for Rural Credit Banks in order to face the challenges of globalization, and legal reform for Rural Credit Banks based on Pancasila Values.
 
Theoretical Reference: Legal reform considers: The moral relationship between citizens and the law; and the ability of the legal and political systems to meet the needs and demands of the people for justice.
 
Method: Normative Juridical Method, referring to laws and regulations as rules or norms, thus this study does not use the term data but rather legal materials.
 
Results and Conclusions: Referring to Law Number 10 of 1998 concerning amendments to Law Number 7 of 1992 concerning Banking, that BPR is limited to ownership only by Indonesian Citizens, Indonesian Legal Entities and Regional Governments. However, Rural Credit Banks in facing globalization, Rural Credit Banks requires funding and capital, especially to issue shares through the stock exchange. This requires a renewal of Banking Law in Indonesia related to the Arrangement of BPR based on Pancasila values ​​in facing the challenges of globalization by guaranteeing the sovereignty of the people's economy without discrimination.
 
Implications: Can foster new needs including in the ease of transactions that can be realized by Rural Credit Banks through banking digitalization or the provision of electronic banking facilities.
 
Originality: Efforts to reform the law on Rural Credit Banks in developing its business require funding and capital carried out through stock issuance on the stock exchange based on Pancasila values.
National Solid Waste Policy: An Analysis in the Municipalities that Make Core of Vale do Jaguari – RS
Authors: Leal Neto Heitor Soares , Lorenzi Júnior David , Viega Geise Loreto Laus , Traverso Luciana Davi
Published: June 2024

Purpose: this study aims to identify how solid waste management occurs in the municipalities that make up Corede Vale do Jaguari - RS, in light of Law 12,305/2010 (PNRS).   Methods: the research adopts a qualitative, descriptive and exploratory approach, conducted through structured interviews with those responsible for solid waste management or the environmental area of ​​the nine municipalities that make up Corede Vale do Jaguari - RS.   Results and discussion: the results reveal significant challenges for the implementation of the PNRS, such as lack of knowledge of the legislation and lack of interest on the part of municipal governments in implementing programs and actions. Although some cities have successful programs, demonstrating an effective understanding of the shared responsibility recommended by the PNRS, only solid waste collection was universally identified among the nine municipalities investigated.   Implications of the research: just as all field research carried out in different locations, with participants from different realities, tends to become a vast and multifaceted object of study, this study also is, as it addresses a Federal Law that, despite not being fully fulfilled, it reveals both controversies and failures as well as concrete examples of success.   Originality/value: the knowledge acquired in this research offers important information about the National Solid Waste Policy (PNRS), enacted in December 2010 and represents a milestone in environmental management in Brazil, aiming to improve the quality of urban life. In this sense, this study highlights the need for advances in solid waste management in the municipalities of Vale do Jaguari, indicating that there is much to be done to achieve the objectives established by PNRS.
Policy Implementation Special Economic Zones Sorong in Analytical Hierarchy Process (AHP) Perspective
Authors: Oktaviana Maria Gorreti , Sjamsuddin Sjamsiar , Sarwono  , Noor Irwan
Published: June 2024

Introduction: This study aims to determine the strategy for implementing policies for the Sorong Special Economic Zone, which is located in the Province of Southwest Papua-Indonesia, through a science-based public policy approach using the perspective of experts' opinions.
 
Methods: The methodology consists of qualitative research and uses the Analytical Hierarchy Process (AHP) method in the analysis process. Qualitative analysis is used to identify factors and sub-factors that influence policy implementation through a synthesis of several policy implementation theories. Meanwhile, the AHP method was used to determine the experts' choices regarding alternative strategies for implementing SEZ policies in Sorong.
 
Result and Discussion: The results of the research show that communication and the level of technical difficulty of problems are factors and sub-factors that greatly influence the SEZ policy implementation process in Sorong.
 
Conclusion:  The best strategy for implementing the SEZ policy in Sorong is to use optimistic alternatives implemented through a different approach, considering cultural factors in the implementation process and having an adaptation strategy to face changes in the situation and conditions of the global economy in the future to maintain the sustainability of the policy.
Strategies For The Generation of New Knowledge Products and Social Appropriation of Knowledge, in Occupational Health and Safety And Environmental Management
Authors: Bourdon-García Rubén Danilo , Villamizar Saudhy Anais Miranda , Oviedo Katherine Montaña , Mariosa Duarcides Ferreira , Falsarella Orandi Mina , Conti Diego de Melo
Published: June 2024

Objective: The aim of this study was to propose and test strategies for the publication of products resulting from knowledge generation and social appropriation activities in the fields of Environmental Management, and Occupational Health and Safety (OHS).
 
Theoretical Framework: This study is grounded in Hessen's general theory of knowledge (2007), which explains relevant aspects of knowledge such as its origin, essence, forms, and criteria of truth.
 
Method: Starting from the theory of knowledge, a strategy was devised with planning, execution, and control stages for the development of a knowledge management system, and from there, strategies for generating and appropriating new knowledge in Environmental Management, and OHS were created.
 
Results and Discussion: The results obtained confirmed the effectiveness of the strategies generated for knowledge generation and social appropriation, identifying actions and limitations. Some guidelines for the knowledge management system that will incorporate these strategies were proposed, aiming for them not to be loose or isolated but within a system designed exclusively for research.
 
Research Implications: The research presents strategies for the publication of products resulting from knowledge generation activities and products resulting from social appropriation activities, which are also applicable to the publication of articles, books, and book chapters on environmental management, occupational health, and safety.
 
Originality/Value: This study contributes to the scientific literature on knowledge management. The relevance and value of this research are evidenced by the originality of the study, as well as by defining strategies and processes for knowledge generation and social appropriation in OHS and environmental management.
Penanggulangan Limbah Ubi Kayu dengan Menggunakan Katalis TiO2/Zeolit Alam Clinoptilolit-Ca secara Sinergi Fotokatalis dan Adsorpsi
Authors: Zilfa Z. , Yusuf Yulizar , Putri Alsa Sepia
Published: June 2024

Cassava waste containing cyanogenic glycosides is very dangerous for the environment because there is cyanide bound to organic compounds. Cyanide bound to organic compounds is degraded by photolysis using TiO2 catalyst/Clinoptilolite-Ca natural zeolite to break the bond between HCN and organic compounds so that it is no longer harmful to the environment, besides that cassava waste also contains suspended solids and organic compounds that affect water quality, resulting in high COD, BOD, TOC, and TSS values in waters. Therefore, the values of COD, BOD, TOC, and TSS were determined before and after degradation. In addition, the effect of time, mass, and type of catalyst (TiO2, Zeolite, and TiO2/Zeolite) on the percentage of cassava waste degradation was also determined. CN- analysis was performed with a UV-VIS spectrophotometer, where maximum absorption occurred at a wavelength of 573 nm. The optimum time of degradation without catalyst is 75 minutes with a degradation percentage of 20.52%, the optimum mass of TiO2/Zeolite catalyst is 0.8 grams with a degradation percentage of 79.97% at 60 minutes, the percentage of degradation using 0.03 grams of TiO2 is 58.65% at 75 minutes, the percentage of degradation using 0.77 zeolite is 35.43% at 75 minutes. COD value before degradation 1406 mg/L and after degradation 465 mg/L. BOD value before degradation 226 mg/L and after degradation 95.4 mg/L. TSS value before degradation 400 mg/L and after degradation 220 mg/L. While the TOC value before degradation was 546 mg/L and after degradation was 670 mg/L. FTIR analysis of cassava waste shows a peak shift indicating degradation, the 750-1000 cm-1 and 1250-1500 cm-1. While the characterization of the TiO2/zeolite catalyst in FTIR and XRD showed no change in the structure of the TiO2/zeolite catalyst before and after degradation.
Development and Implementation of the D-Pace Ion Source Automation System for the VITA Accelerator
Authors: Koshkarev A. M. , Shchudlo I. M. , Taskaev S. Yu.
Published: June 2024

The VITA accelerator neutron source based on a vacuum insulated tandem accelerator operates at the Institute of Nuclear Physics SB RAS. The development of a separate compact facility for the generation of fast neutrons is an actual task, it will allow the treatment of malignant tumors via boron-neutron capture therapy with fast neutrons and a number of other applications. To control the facility, store and analyze data, the author has previously created an automation system that allows the operator to provide long-term stable proton or deuteron beam production in a wide range of energy and current variations, and scientific staff to obtain experimental data and process them in real time.

Currently, the BINP SB RAS is manufacturing the accelerating neutron source VITA for the National Medical Research Center for Oncology named after N. N. Blokhina in Moscow. It is planned to put it into operation in 2025. In contrast to the operating experimental installation of the BINP SB RAS, an ion source from the D-Pace company (Canada) will be used.

This paper presents the automation procedure for the new ion source, control algorithms, PID controller coefficients and operating parameters, which made it possible to obtain a maximum average beam current on the Faraday cup of 13 mA with a stability of 0.14%.
Analysis of a Modifi ed Pierce Electrode Implementation
Authors: Li R. V. , Devyataikina T. A. , Nikiforov D. A.
Published: June 2024

The study provides a comparative analysis of some approximate and exact solutions for a modified forming electrode in a Pierce gun with a thermal gap. Using numerical simulation, the degree of equivalence of different solutions is shown from the point of view of practical implementation and beam quality. Finally, a specific shape of the modified Pierce electrode is presented, taking into account realistic constraints on the design freedom.
A Prospective, Open-Label, Nonrandomized Clinical Trial Using Polyvinyl Alcohol Antibacterial Foam for Debridement of Diabetic Foot Ulcers
Authors: Lullove Eric
Published: June 2024

Background. Diabetic foot ulcers (DFUs) pose significant challenges for patients, often leading to chronic inflammation, reduced mobility, and chronic pain. Despite being less prevalent in the United States compared to other nations, the economic burden of DFUs remains substantial, with an estimated annual cost ranging from $9 billion to $13 billion. Furthermore, DFUs are a leading cause of nontraumatic lower extremity amputations and significantly impact health care systems and work productivity. Objective. This study aimed to evaluate the effectiveness of a polyvinyl alcohol (PVA) foam dressing containing gentian violet/methylene blue (GV/MB) in managing chronic DFUs. Materials and Methods. A single-center study was conducted involving 20 patients with full-thickness chronic lower extremity wounds, including DFUs. Patients received treatment with a PVA foam dressing with GV/MB applied in an outpatient setting over a period of 4 weeks. Wound size, bacterial presence, and healing progress were assessed using fluorescence imaging and wound measurements. Results. The study included 13 males and 7 females with an average age of 64.2 years. After 4 weeks of treatment, the average DFU size decreased by 53%, with 4 patients achieving complete wound closure. Reduction in ulcer size was strongly correlated with the use of surgical debridement and PVA GV/MB foam. Fluorescence imaging demonstrated a significant reduction in bacterial presence in all patients by the end of the study. Follow-up at 3 and 6 months showed no recurrent ulcerations, indicating the potential for long-term efficacy. Conclusion. The findings suggest that PVA GV/MB foam dressings, when combined with surgical debridement, are effective in promoting the healing of chronic DFUs. Further research with larger, controlled studies is warranted to confirm these findings and assess cost-effectiveness.
The Utility of Negative Pressure Wound Therapy in the Management of Complex Deep Cardiothoracic Surgical Site Infections
Authors: Aljehani Yasser , Alrashaid Farouk , El-bawab Hatem , Alkhaldi Naif , Alsadery Hmood , Alayyaf Norah , AlSaikhan Jana , AlShamekh Sumiyah
Published: June 2024

Background. Complex deep surgical site infection in the cardiothoracic surgery patient that reaches the sternum and even the mediastinum, causing osteomyelitis and mediastinitis, is associated with high rates of morbidity and mortality. Negative pressure wound therapy (NPWT) can aid in achieving favorable outcomes in patients with complex surgical site infections by promoting wound healing and shortening the hospital stay. NPWT is widely recognized for its advantages and has recently been used in both cardiothoracic and non-cardiothoracic settings. Objective. To evaluate the efficacy of NPWT in the management of complex deep surgical site infection after cardiothoracic surgery. Materials and Methods. A retrospective chart review of all complex cardiothoracic cases admitted to the cardiac and thoracic surgery divisions for surgical intervention to treat postoperative surgical wound infections. Results. A total of 18 patients were included, with a male-to-female ratio of 5:4. The mean (SD) age was 48.7 (16.5) years. The cases reviewed were complex, and the duration of the NPWT application ranged from 4 days to 120 days, with an average hospital stay of 62.8 days. Seventy-eight percent of patients required antibiotics (or had positive wound cultures); in 55.6% of these patients, polymicrobial infection was detected. No major complications were related to NPWT. Conclusion. The study findings show that using NPWT in complex deep sternal and thoracic infections can enhance wound healing, shorten the hospital stay, and decrease morbidity and mortality secondary to wound infection in cardiothoracic patients.
Circuit resistance training strategy on maximal strength, rate of force development and power: A random model meta-analysis
Authors: Kahraman Yeliz , Hocalar Aykut
Published: June 2024

Backround Problems: Circuit resistance training is a type of strength and power training mode according to short-term strength, rate of force development, and power strategy; however, priority maximises performance outcomes and is not used on trained and untrained resistance populations. Research Objectives: Increased performance on developing high-intensity resistance sessions and short time intervals was investigated with systematic review and meta-analysis methodology. This meta-analysis methodologic approach aimed to report popular circuit resistance training on maximal strength, rate of force development, and power able to short-time interval set-up micro-periodization. Methods: By following this way, a high-intensity resistance combination short-time interval strategy was provided between 2008 and 2023. A study using keywords of circuit resistance training, dynamic strength, explosive power, and rate of force development was conducted to explore SportDiscus, PubMed, and the and the Web of Science databases investigated in a random model meta-analysis. Findings and Results: Exploration of circuit resistance training contributed to clarifying maximise strength and power performance under probable report outcomes detected to analysis of metadologic quality risk of bias, effect size, and mean difference. Conclusion: In conclusion, circuit resistance training strategy resulted in maximising strength and power regimes, but sufficient research has not yet been carried out as a proper periodic session adapted to detect rate of force development and power combination in the literature. In addition, circuit resistance training strategic approach may be re-performed to plan strength and power.
A Carrier-free Peptide Co-assembled System with Synergistic Antitumor Effect Combines Immunotherapy and Sonodynamic Therapy
Authors: Wang Weizhi , Zhang Limin
Published: June 2024

Blocking programmed cell death ligand 1 (PD-L1) in tumor cells is an effective therapy strategy to achieve immune system activation for tumor therapy, however only a few patients can benefit from it. Development of synergistic therapy with checkpoint PD-L1 blockade immunotherapy is beneficial to enhance antitumor effect. Herein, we constructed a carrier-free system EH@Ag2S co-assembled by peptide nanofiber and Ag2S nsanoparticles to achieve a superadditive (1 + 1 > 2) antitumor effect. EH nanofiber can block PD-L1, and Ag2S can produce reactive oxygen species (ROS) under ultrasound irradiation and induce cell apoptosis. Further, in vivo mice experiment also confirmed the high efficiency of this carrier-free co-assembled system in successfully inducing anti-tumor response while inhibiting tumor growth. We believe that this highly bioavailable and multifunctional therapeutic system may become a promising nanoplatform for tumor therapy.
Microfluidic platform for screening the activity of immobilized photocatalysts for degradation of organic water pollutants
Authors: Roibu Anca , Udroiu Razvan , Dinu Alexandru , Andronic Luminita
Published: June 2024

Photochemistry screening platforms have the potential to accelerate the discovery and development of new photocatalysts. This study presents the design and characterization of a novel activity screening platform of immobilized photocatalytic films for degrading water pollutants. The compact testing system is engineered with four 3D-printed microreactors and a rotative multi-wavelength LED light source, which is capable of emitting at the 395, 409, 413, and 443 nm. Despite the different LEDs being placed in a compact space, 95% of the light that reaches the photocatalytic films is emitted by the LEDs directly opposite them. Therefore, the design allows for a minimum of 16 distinct testing conditions by simply rotating the light source. The performance of the microfluidic platform was characterized using the photocatalytic degradation of a pesticide, imidacloprid, in the presence of P25 TiO2, immobilized as thin film on glass plates. The results demonstrated a consistent degradation efficiency of around 35 % at 395 nm, with negligible variation across the four microreactors and no influence of the testing order at 395, 409, 413 and 443 nm. Notably, the photocatalytic film activity did not decrease after 6 hours of operation and under five successive illumination conditions. The screening conditions were optimized using the dynamic water infusion which increased the degradation efficiency of the imidacloprid to 71 %. In addition, the dynamic illumination allowed the sequential operation of the 4 types of LEDs, and led to a halved degradation efficiency despite the LEDs were lighted up for only a quarter of the time. This microfluidic platform diminishes the manual labor and the quantities of photocatalyst and polluted water required per test compared to the batch screening, consequently, it emerging as an efficient and sustainable tool that is suitable for the automated screening of immobilized photocatalysts.
Tailoring the dynamics of DUT-5 nanocrystals: from rigid nanoparticles to flexible nanowires
Authors: Saad Ali , Gobeaux Frédéric , Bon Volodymyr , Plana-Ruiz Sergi , Sicard Clémence , Frégnaux Mathieu , Dasgupta Sanchari , Biswas Subharanjan , Dassouki Khaled , Baptiste Benoît , Canossa Stefano , Kaskel Stefan , Menguy Nicolas , Guillou Nathalie , STEUNOU Nathalie
Published: June 2024

Here we describe the synthesis of a series of 1D anisotropic DUT-5(Al) nanostructures differing by their crystal dimensions and aspect ratio. Very long and monodisperse DUT-5(Al) nanowires (NWs) with length exceeding 6 µm were designed by using graphene oxide (GO) nanoscrolls as structure directing agents while shorter DUT-5(Al) nanorods 50 nm in length or polydisperse DUT-5(Al) samples with a broad size distribution were prepared without any GO. Remarkably, these materials were also differing by their dynamic properties upon guest molecules adsorption. While DUT-5(Al) nanorods exhibited a rigid large pore (lp) phase, it was revealed that DUT-5(Al) NWs could present a gating behaviour upon guest adsorption involving a structural transition from a highly disordered narrow pore (np) phase to the lp phase. The structure of DUT-5(Al) NWs as well as their guest-responsive structural flexibility were fully characterized by coupling high resolution TEM, 3D electron diffraction, high resolution synchrotron PXRD and PDF, adsorption isotherms and in situ PXRD. To the best of our knowledge, this study delivers an unprecedented design of flexible DUT-5(Al) NWs whereas this MOF was previously regarded as a rigid porous hybrid material. Moreover, it demonstrates that tuning the aspect ratio of MOF particles can influence their structural flexibility.
Integración de sistemas de gestión en empresas de la industria alimentaria de Aguascalientes-México
Authors: Castañeda Fernández Dulce Inés , Mejía Reyes Juan Gerardo , Carlos Ornelas Carmen Estela , Castillo Corral Daniel , Reséndiz Serrano Héctor Manuel
Published: June 2024

En este artículo se reportan los niveles de integración y los beneficios obtenidos por diecisiete empresas de la industria alimentaria de Aguascalientes-México que han integrado dos o más sistemas de gestión. Se consideraron como niveles de integración a la armonización documental, a la integración parcial y a la integración completa; y como beneficios a la fuerza laboral, a la organización y al desempeño. El 92 % cumplía con la armonización documental; el 80 %, con integración parcial; el 73,5%, con la integración completa. Los mayores beneficios fueron los beneficios de desempeño en la mejora de la calidad de los productos o servicios en un 65 % de las empresas.
Application of the Beauty of Meaning in Chinese Sculpture Art
Authors: Lu Xingjian , Pan Chang
Published: June 2024

Chinese sculpturing is a significant form of expression in traditional Chinese art. Like other traditional art forms, Chinese sculpture art is also deeply influenced by the philosophical ideas of its predecessors, striving for the beauty of subtle and implicit meaning in artistic expression. This article provides a brief interpretation of the beauty of meaning in Chinese sculpture art, with a focus on analyzing its application in Chinese sculpture art. This article analyzes the role of the beauty of meaning in the development of Chinese sculpture art from the fields of lines, blocks, surfaces, spatial patterns, and freehand brushwork, to provide reference and inspiration for relevant artists and sculpture designers.
The Impact of Air Pollution Regulations on High-Quality Economic Development
Authors: Lou Fangyuan
Published: June 2024

The pursuit of high-quality economic development is a critical challenge in the context of increasing environmental concerns, particularly air pollution. This study delves into the efficacy of environmental regulations in fostering economic growth that is both sustainable and of high quality. Utilizing the entropy weight method, an index system for high-quality economic development is established, and a comprehensive analysis of panel data from 30 provinces in China, spanning from 2008 to 2020, is conducted through a two-way fixed differential model. The study examines the regional heterogeneity in the impact of policy and explores the mediating roles of industrial structure upgrading and technological innovation in advancing high-quality economic development within regions prioritized by policy. The findings reveal that regulatory policies can indeed enhance high-quality economic development, albeit with regional disparities observed between the eastern and central regions. The paper concludes with a set of targeted recommendations for policy implementation.
A Study on the Self-presentation of Ethnic Minority Youth on Short Videos
Authors: Fu Qingyi
Published: June 2024

This study conducts an in-depth study on the self-presentation behavior of ethnic minority youth on the short video platform, and aims to reveal the characteristics and values behind it. As an important participant of the short video platform, the self-presentation behavior of ethnic minority youth has an important social value. This study analyzes the self-presentation behavior of ethnic minority youth on the short video platform from the perspectives of impression management and background and also notes the possible negative effects of the short video platform. It is expected to further promote social attention to and respect for ethnic minority cultures to build a harmonious and diversified social environment.
Microbial Chaff Reinforcement: Preparation and Performance Study of a Soil Stabilizer
Authors: Cui Shuhe , Wang Mengrui , Fan Donghui
Published: June 2024

The fungus bran is the waste of the fruiting body of edible fungi, which is rich in a variety of protein and fiber, amino acids, polysaccharides, enzymes, and other nutrients, and has high reuse value. In this study, the fungus bran produced by desert Tremella was used as the raw material to prepare the fungus bran which could provide plant nutrients and water retention function. After 7 days of experiments, it was found that the sand fixation material had good water retention performance and significantly increased the aggregate performance of the sand. The results of FTIR and SEM analysis showed that the sand chaff was involved in the agglomeration process of sand, and the sand and the chaff were well combined, with a better spatial network structure and surface morphology. Therefore, it is a great prospect to explore the reuse of solid waste of fungal bran in desert afforestation.