bluuebunny/crossref_metadata_2025 huggingface dataset:
Corona-virus disease 2019 vaccination acceptance and associated factors among residents of Dire Dawa Administration, Eastern Ethiopia: a community-based cross-sectional study
Authors: Jidha Tafese Dejene , Degnet Endaye , Tefera Bereket , Amenu Demisew , Beressa Girma , Hailu Mickiale
Published: December 2023

Background: Corona virus disease 2019 (COVID-19) is an extremely contagious viral infection caused by the severe acute respiratory syndrome coronavirus 2. Scientific evidence on COVID-19 vaccine acceptance and predictors among residents in low-income countries like Ethiopia is sparse. Therefore, we aimed to assess level of the COVID-19 vaccine acceptance and associated factors among residents of Dire Dawa Administration, Eastern Ethiopia.
Methods: A community-based cross-sectional study was conducted among 840 residents in Dire Dawa Administration from May 18th to June 18th, 2021. Multistage cluster sampling followed by systematic random sampling was used to select respondents. A pretested interviewer-administered structured questionnaire was used to collect the data from respondents. Bivariable and multivariable logistic regression were used to identify predictors of the COVID-19 vaccine acceptance. The odds ratio (OR) along, with a 95% confidence interval (CI), was used to estimate the strength of the association.
Results: Out of 840 respondents recruited, the proportion of COVID-19 vaccine acceptance was found to be 54.4% (457/840); (95% CI: (51.0%, 57.7%)). Being males [AOR=1.85, 95% CI: (1.35, 2.54), P<0.001], not having a current habit of substance use [AOR=2.38, 95% CI: (1.73, 3.26), P<0.001], having a monthly income of less than 51.31USD [AOR=0.19, 95% CI: (0.04, 0.88), P=0.001]; and not having a prior history of vaccination experience [AOR=0.40, 95% CI: (0.29, 0.54), P<0.001] were significantly associated with COVID-19 vaccine acceptance.
Conclusion: This study reveals that the COVID-19 vaccine acceptance was low. Being male, having a lower income in the family, not having a current habit of substance use, and not having previous vaccination experience were factors associated with COVID-19 vaccine acceptance. Health information dissemination and economic empowerment are crucial to improving COVID-19 vaccine acceptance among the community. The study’s findings would have implications for policymakers.
Insights into RC time Curve fit analysis of pulmonary artery pressure decay
Authors: Manouras Aristomenis , Nagy Aniko Ilona , Lund Lars H , Johnson Jonas
Published: December 2023

The notion of a constant relationship between resistance and capacitance (RC time) in the pulmonary circulation has been challenged by more recent research. The RC time can be obtained using either a simplified empirical approach or a semilogarithmic equation. Although direct curve-fit analysis is a feasible and ostensibly reference approach for RC analysis, it remains largely unexplored. We aimed to study the relationship between various RC methods in different states of pulmonary hemodynamics.
Methods: In total, 182 patients underwent clinically indicated right heart catheterization. The pressure curves were exported and processed using the MATLAB software. We calculated the RC time using the empirical method (RCEST), semilogarithmic approach (RCSL), and direct measurement of curve fit (RCFIT).
Results: Among 182 patients, 137 had pulmonary hypertension due to left heart disease (PH-LHD), 35 had pulmonary arterial hypertension (PAH), and 10 demonstrated normal hemodynamics (non-PH). RCEST consistently overestimated the RCFIT and RCSL measurements by a mean of 75%. With all three methods, the RC values were longer in the PAH (RCFIT = 0.36±0.14 s) than in the PH-LHD (0.27±0.1 s) and non-PH (0.27±0.09 s) groups (p < 0.001). Although the RCSL and RCFIT values were similar among the three subgroups, they exhibited broad limits of agreement. Finally, the RCEST demonstrated a strong discriminatory ability (AUC = 0.86, p<0.001, CI = 0.79-0.93) in identifying PAH.
Conclusion: RC time in PAH patients was substantially prolonged compared to that in PH-LHD and non-PH patients. The use of the empirical formula yielded systematic RC overestimation. In contrast, the semilogarithmic analysis provided reliable RC estimates, particularly for group comparisons.
Prophecy and promise: Sociotechnical imaginaries in academic medicine strategic planning
Authors: Rowland Paula , Brydges Madison , Kulasegaram Kulamakan (Mahan)
Published: December 2023

Purpose
Along with other industries, healthcare is becoming increasingly digitized. Our study explores how the field of academic medicine is preparing for this digital future. We conducted an analysis of strategic plans from two organizational forms that shape the field of academic medicine: medical schools and academic health science centres.
Method
This study was conducted in 2023. Active strategic plans available in English were collected from faculties of medicine in Canada (n = 14), departments in medical schools (n = 17), academic health science centres (n = 23) and associated research institutes (n = 5). In total, 59 strategic plans were subjected to a practice-oriented form of document analysis, informed by the concept of sociotechnical imaginaries.
Results
While both organizational types are attending to the digital future of healthcare, this future seems to be under-specified in the strategic planning of medical schools. In contrast, academic health science centres are pursuing a robust sociotechnical future with transformative implications for how care is conducted, what forms of knowledge are prioritized, how patients and patienthood will be understood, and how data work will be distributed.
Conclusions
Looking through the lens of sociotechnical imaginaries, this study illuminates strategic plans as framing desirable futures, directing attention towards specific ways of understanding problems of healthcare, and mobilizing the resources to knit together social and technical systems in ways that bring these visions to fruition. There are bound to be tensions as these sociotechnical imaginaries are translated into material realities. Many of those tensions and their attempted resolutions will have direct implications for the expectations of health professional graduates, the nature of clinical learning environments, and future relationships with patients. Sociology of digital health and science and technology studies can provide useful insights to guide leaders in academic medicine shaping these digital futures.
Active Vibration Control and its application to a three-story building
Authors: Felahi Saci
Published: December 2023

In summary, a comprehensive understanding of the dynamic interaction between the Active Mass Driver and the three-story structure, coupled with careful experimental validation, is essential for the success of vibration isolation and earthquake protection efforts. Given that you are working with an Active Mass Driver (AMD) control system for vibration isolation in a three-story experimental structure, it's essential to understand how the AMD interacts with the structure to attenuate ground disturbances during earthquakes.
The mediation effect of Systemic Immunity Inflammation Index between urinary metals and TOFAT among adults in the NHANES dataset
Authors: Nie Junfeng , Lu Dengqiu , Zhang Cong , Hu Zhumin , Xian Cuiyao , He Minxing , Zhang Weipeng
Published: December 2023

Background: Systemic Immune Inflammatory Index (SII) is a novel indicator of inflammation. However, no studies have reported the effect of SII on the association between metals and total fat (TOFAT). We aim to investigate the mediated effect of SII on the relationship between urinary metals and TOFAT in a US adult population.
Methods: This cross-sectional study was conducted among adults with complete information on SII, urine metal concentrations, and TOFAT from the 2011-2018 National Health and Nutrition Examination Survey (NHANES). Multifactorial logistic regression and restricted cubic splines were used to explore the association between urine metal levels and TOFAT. Furthermore, serial mediation analyses were used to investigate the mediating effect of SII on metals and TOFAT. Results: A total of 3324 subjects were included in this study. After adjusting for covariates, arsenic (As), cadmium (Cd), cobalt (Co), cesium (Cs), inorganic mercury (Hg), molybdenum (Mo), manganese (Mn), lead (Pb), and antimony (Sb) had negative and significant decreased trends of odds ratios for TOFAT (all P for trend < 0.05). In the total population, we found that Cd, Co, and Tu had a significant positive association with SII [β = 34.67 (95%CI: 1.65, 67.70); β = 54.49 (95%CI: 12.20, 96.78); β = 29.46 (95%CI: 1.67, 57.24)], whereas As and Hg had a negative association with SII. The results of mediation analysis showed that SII had significant mediated effects on the associations of Co with TOFAT, and the beta coefficient of mediating effect was 0.8% (95%CI: 0.2, 0.5%; P= 0.020). The mediating effects of SII were not statistically significant on the associations of As, Cd, and Hg with TOFAT (all P > 0.05).
Conclusions: Our findings suggested that exposure to As, Cd, and Hg would directly decrease the level of TOFAT. However, Co would increase TOFAT, completely mediated by SII, which was mainly exerted in females rather than males.
Chmp1A regulates pancreatic cancer cell growth via SIM-medicated SUMOylation and UIM-mediated ubiquitination, opposed through NLS-mediated signaling activities
Authors: Park Maiyon , Cai Mei , Thacker Austin Tyler , Roberts Carson , Qin Tiantian , Sakamoto Devin
Published: December 2023

Background Chmp1A is a member of ESCRT-III family that functions in the lysosomal degradation of proteins via the formation of MVBs at the final stage of lysosomal degradation. ESCRT-0, -I, and –II were shown to contain UIM for interaction with ubiquitinated cargo proteins destined for MVBs. However, Chmp1A of ESCRT-III has not previously been reported to contain UIM. The purpose of this study is to examine if Chmp1A contains motifs such as UIM through which it is modified and to examine the effect of these modifications on pancreatic cancer cell growth.Methods Protein database search was employed to investigate whether Chmp1A contains UIM or similar motif. Immunoprecipitation assays were used for examining posttranslational modifications, WB for protein expression, microscopy for subcellular localization, MTT assays for proliferation, transfection method for overexpression of various Chmp1A constructs in pancreatic cancer cells, and in vitro Ubiquitination assays for ubiquitination of rhChmp1A.Results We found that Chmp1A contains putative SIMs and a UIM. We observed that Chmp1A is slightly SUMOylated in normal pancreatic epithelial cells, which increases as pancreatic cancer progresses towards malignancy. In pancreatic cancer cells, full-length Chmp1A protein is significantly multi-SUMOylated but slightly mono-ubiquitinated. The NLS-deleted Chmp1A eliminated the PTMs by Sumo and ubiquitin, which were verified by SIM and UIM mutants. When overexpressed, Chmp1A was detected at the nucleus and the cytoplasm of which overlaps with late endosomal protein Lamp1. However, both mutants had no expression in the nucleus. SIM mutant showed spotty cytoplasm expression that overlaps with Lamp1. UIM mutant exhibited uniform cytoplasmic expression with little overlap with Lamp1. Both mutants of Chmp1A inhibited cell growth significantly, demonstrating that PTMs of Chmp1A are required for cancer cell growth.Conclusion We identified SIMs and a UIM of Chmp1A and verified its PTM by Sumo and ubiquitin. Based on our data, we conclude that SUMOylation and/or ubiquitination is essential for the nuclear signaling mediated cancer inhibitory functions of Chmp1A. We also conclude that the excess PTM of Chmp1A by Sumo and/or ubiquitin could lead to cancer promotion either by inhibiting tumor suppressors such as ATM or p53 or by activating oncogenic activities.
Nomogram for assistant diagnosing acute suppurative cholangitis: a case-control study
Authors: He Yu-qi , Han Wang , Zhao Yi-hang , Lv Guan-ting , Liu Zi-jun
Published: December 2023

Background:
Acute suppurative cholangitis (ASC) lacks sensitive and specific preoperative diagnostic criteria. This study aimed to investigate the relationship between the grading system of acute cholangitis (AC) according to the Tokyo Guidelines 2018 (TG18) and the diagnosis of acute suppurative cholangitis (ASC), searching for independent risk factors of ASC and develop a nomogram to discriminate ASC from acute nonsuppurative cholangitis (ANSC) accurately.
Methods:
After applying the inclusion and exclusion criteria, 401 patients with acute cholangitis (AC) were retrospectively analyzed at Nanjing First Hospital between January 2015 and July 2023. Based on the presence of suppurative bile, the patients were divided into two groups. SPSS version 27.0 and R studio software were used to analyze data obtained from medical records.
Results:
Among the 401 patients, 102 had suppurative bile (the ASC group; AC grade I: 40 [39.2%], AC grade II: 27 [26.5%], AC grade III: 35 [34.3%]), whereas 299 did not have (the ANSC group; AC grade I: 157 [52.5%], AC grade II: 92 [30.8%], AC grade III: 50 [16.7%]). Multivariate logistic regression analysis identified concurrent cholecystitis, CRP, PCT, TBA, and bile duct diameter as independent risk factors for suppurative bile, and all of these factors were included in the nomogram. The calibration curve exhibited consistency between the nomogram and the actual observation, and the area under the curve was 0.875 (95% confidence interval: 0.835–0.915), sensitivity was 86.6%, and specificity was 75.5%.
Conclusion:
The nomogram demonstrated excellent predictive performance in assisting in diagnosing ASC.
Chemotherapy-induced febrile neutropenia (FN) in the US: healthcare resource utilization (HCRU) and costs
Authors: Flanigan Jeanine A. , Yasuda Marie , Chen Chi-Chang , Li Edward C.
Published: December 2023

Purpose
Febrile neutropenia (FN) is a known side effect of chemotherapy, often requiring hospitalization. Economic burden increases with an FN episode and estimates of cost per episode should be updated from real-world data.
Methods
A retrospective claims analysis of FN episodes in patients with non-myeloid malignancies from 2014 to 2021 was performed in IQVIA PharMetrics® Plus database. FN episodes were defined as having same-day claims for neutropenia and fever or infection, plus antibiotic in outpatient settings, following a claim for chemotherapy; index date was defined as the first claim for neutropenia/fever/infection. Patients receiving bone marrow/stem cell transplant and CAR-T therapy were excluded, as were select hematologic malignancies or COVID-19. Healthcare utilization and costs were evaluated and described overall, by episode type (w/wo hospitalization), index year, malignancy type, NCI comorbidity score, and age group.
Results
7,033 FN episodes were identified from 6,825 patients. Most episodes had a hospitalization (91.2%) and 86% of patients had ≥ 1 risk factor for FN. Overall, FN episodes had a mean (SD) FN-related cost of $25,176 ($39,943). Episodes with hospitalization had higher average FN-related costs versus those without hospitalization ($26,868 vs $7,738), and costs increased with comorbidity score (NCI = 0: $23,095; NCI > 0–2: $26,084; NCI ≥ 2: $26,851).
Conclusions
FN continues to be associated with significant economic burden, and varied by cancer type, comorbidity burden, and age. In this analysis, most FN episodes were not preceded by GCSF prophylaxis. The results of this study highlight the opportunity to utilize GCSF in appropriate oncology scenarios.
Time required for psychological testing of dementia is useful for predicting asymptomatic brain lesions: validation using CADi2
Authors: Iwasa Kenichi , Takamura Masahiro , Kuroda Yoko , Asayama Kosuke , Aritake Shun , Abe Satoshi , Nagai Atsushi
Published: December 2023

Cognitive test duration is related to brain lesions. However, few studies have addressed automated timing. CADi2 is a cognitive evaluation software. This study aimed to evaluate the use of automatically calculating the time required to answer questions in a 10-item in CADi2, in addition to the questionnaire score, to assess cognitive function and estimate asymptomatic brain lesions. Among 556 patients who underwent a brain scan at the Shimane Institute of Health Science between March 28, 2019 and March 24, 2021 and interacted with CADi2, we enrolled 429 patients aged ≥ 50 years with paraventricular and deep subcortical white matter hyperintensity scores of ≥ 2 as per the Fazekas classification, microbleeds, and asymptomatic brain lesions. CADi2 total time was more accurate at predicting the presence of a silent brain infarction (SBI) than the Mini-Mental State Examination Particularly, the time required to answer questions 2, 7, and 8 was related to the presence of SBI. The odds ratio of having SBI was 3.75 (2.00–7.05) when using the summed time to answer these three questions. The time required for cognitive testing using CADi2 is useful for predicting the presence of asymptomatic lesions and could be used as a non-invasive, prehospital stroke risk screening tool.
Non-malignant pathological results from CT-guided biopsy for pulmonary nodules: A predictive model for identifying false-negative results
Authors: Wang Xu-Zhou , Wang Jing-Ya , Meng Tao , Shi Yi-Bing , Sun Jin-Jun
Published: December 2023

Background: Computed tomography (CT)-guided biopsy (CTB) procedures are commonly used to aid in the diagnosis of pulmonary nodules (PNs). When CTB findings indicate a non-malignant lesion, however, it is vital that false-negative results are accurately identified. Accordingly, the present study was designed with the goal of identifying relevant predictors for the construction of a model capable of predicting false-negative cases among patients undergoing CTB for PNs who receive non-malignant results.
Materials and Methods: Consecutive patients from two centers who received CTB-based non-malignant pathological results when undergoing evaluation for PNs from January 2016 to December 2020 were retrospectively evaluated. A training cohort was used to identify factors that were predictive of false negative results, enabling the establishment of a predictive model. The remaining patients were used to establish a testing cohort that served to validate predictive model accuracy.
Results: The training cohort enrolled 102 patients with PNs exhibiting CTB-based non-malignant pathological findings, each of whom underwent CTB for a single nodule. Of these patients, 85 and 17 respectively exhibited true negative and false negative PNs. Through univariate and multivariate analyses, higher standardized maximum uptake values (SUVmax, P = 0.001) and CTB-based findings of suspected malignant cells (P = 0.043) were identified as being predictive of false negative results. These two predictors were then combined to establish a predictive model. The area under the receiver operating characteristic curve (AUC) for this model was 0.945, with corresponding sensitivity and specificity values of 88.2% and 87.1%. The testing cohort included 62 patients, each of whom had a single PN. When the developed model was used to evaluate this testing cohort, this yielded an AUC value of 0.851.
Conclusions: The predictive model developed herein exhibited good diagnostic utility when identifying false-negative CTB-based non-malignant pathological results among patients with PNs.
Clinical characteristics of severe influenza and molecular epidemiology of influenza viruses
Authors: Bo Yan , Miao Chuhan , Li Beilei , Yang Yumeng , He Jianxun
Published: December 2023

Background
The protocol aims to investigate the clinical features of severe cases of influenza and the genetic diversity and transmission patterns of influenza viruses.
Methods
The study collects clinical data from patients with severe flu, including symptoms, disease progression, and outcomes. Additionally, molecular analysis will be conducted to identify and characterise the influenza viruses circulating in the population.
Discussion
The findings from this study will provide valuable insights into the clinical manifestations of severe influenza and the genetic variations of influenza viruses, which can contribute to the development of effective prevention and control strategies.
• Guiding significance for improving the understanding of recent influenza epidemic patterns and diagnosis and treatment capabilities.
• Provide practical biological evidence for influenza diagnosis and prevention.
Trial registration
retrospectively registered.
Strengthening initial teacher education programs to deliver confident, effective, classroom-ready graduates: A feasibility study
Authors: Riley Nicholas , Leahy Angus A. , Eather Narelle , Verswijveren Simone J.J.M. , Lander Natalie
Published: December 2023

Purpose TransformEd is an evidence-based program that targets initial teacher education to equip future teachers with innovative strategies that increase the health, wellbeing and education outcomes of school children. Feasibility, effectiveness and implementation research demonstrate that TransformEd significantly enhances pre-service teachers’ confidence and competence to deliver such strategies. However, to date, the program has only been tested in undergraduate teaching degrees. It is important to gather more evidence for the feasibility and efficacy of the program at all levels of initial teacher education, including at postgraduate level.
Methods A pilot feasibility study was conducted to examine the feasibility of embedding TransformEd in a Master of Teaching degree at one Australian university. Preliminary efficacy was measured by pre- and post-program surveys completed by Master of Teaching pre-service teachers who received the 12-week TransformEd program. Implementation was measured by adherence checklists completed by lecturers who delivered TransformEd. Post-program focus groups and interviews with senior academics and lecturers, respectively, explored perceptions of all eight domains of feasibility.
Results Survey results demonstrated that the TransformEd program was positively received by pre-service teachers (n=21), resulting in improvements in several measures of teaching confidence and competence in regard to delivering strategies to improve school children’s health, wellbeing and learning. The TransformEd strategies were well adopted by lecturers (n=3) and implementation increased over time. Both lecturers and senior academics (n=2) had positive perceptions of the program, highlighting its feasibility in postgraduate initial teacher education.
Conclusion This pilot study provides support for the feasibility TransformEd program in the context of postgraduate initial teacher education. The findings have direct implications for the progression of TransformEd from pilot feasibility to a future definitive trial in postgraduate initial teacher education, which may provide a population –level impact on the health, wellbeing and education outcomes of all Australian children.
A study on the causes of chronic obstructive pulmonary disease
Authors: Jebbeh Omar Al , Khalil Mohammed Abdulbasset , Ali Diaa Haj , Al-Bardan Hussam
Published: December 2023

Background: The importance of the research lies in that it sheds light on an important medical issue, which is the causes leading to chronic obstructive pulmonary disease, and shows the extent of its danger to the individual and its negative role in exacerbating the disease.
Materials and methods: A retrospective cohort study, was conducted in Damascus Hospital in the Syrian Arab Republic in the city of Damascus from April 2020 to November 2023. The study included patients with chronic obstructive pulmonary disease (COPD)
Results: a sample of 200 patients with COPD who participated in the study, the largest percentage were from the group of 61 years and over with a percentage of 68%, and the largest percentage were from males with 78%. 98% of the sample were smokers. 21% suffered from asthma, 20% used firewood, and the dominant symptom was dyspnea, at a rate of 91%, followed by cough, at a rate of 88%, and 94.3 % of those who had a cough were productive, not dry. 51.9% had mucous sputum.
48.3% of patients had dyspnea of the fourth degree, and 90% of patients had performed chest X-ray.
Conclusion: It is necessary to give special importance to the causes leading to chronic obstructive pulmonary disease in terms of management and limiting its spread, as it effectively contributes to reducing the severity of the disease and preserving the organ.
Effect of Gamma-Irradiated Ceramic Wastewater Sludge on Photosynthetic Pigments of Phaseolus Vulgaris L. (Cv. Valentino and Cv. Nebraska) Plants
Authors: Sasi Ghada Salem , El-Araby Magda M
Published: December 2023

The common bean plant is a highly polymorphic species, annual herb, erect and bushy, 20–60 cm tall, or twining with stems 2–3 m long, with a taproot and nitrogen nodules which the bacteria could convert nitrogen gas and stores it in the common bean plant roots. Leaves are alternate, green, or purple, trifoliolate, stipulate, petiolate, markedly pulvinus at base; leaflets ovate, entire; acuminate, 6–15 cm long, 3–11 cm wide. Many soils have been contaminated with several pollutants, mostly arising from wastes of human activities such as the use of pesticides, sewer sludge, mining and smelting sources, radioactive substances, and industrial dischargers. These different contaminants can degrade the soil and cause a negative impact on the plant due to disturbing nutrient cycling within ecosystems and subsequently human health. This study aimed to elucidate the mechanism by which the plant may cope with heavy metals stress represented in this study in the form of industrial ceramic wastewater sludge. And, evaluating the role of gamma radiation on ceramic wastewater sludge, could reduce the percentage of the endogenous levels of heavy metals in ceramic sludge. This study investigates the influence of Photosynthetic pigments of the two common bean cultivars Valentino and Nebraska which are grown in light soil clay/sand (1:1) incorporated with ceramic-wastewater sludge (CWWS) non-irradiated (1% and 2%) and gamma-irradiated (2.5 kGy and 10 kGy) for 30 days. The application of non-irradiated CWWS induced an elevation in the contents of chlorophylls a, b, and carotenoids in the two cultivars while a reverse trend was observed in the leaves of both cultivars treated with gamma irradiated CWWS.
The Unrest of the Enlightened Self: The Scope of Human Action in Spinoza
Authors: Charpenel Eduardo
Published: December 2023

My aim in this paper is to examine some of the distinctive facets of human action in Spinoza’s philosophy and show their intrinsic connection with each other. By analyzing in detail how Spinoza addresses different aspects of human action in his main work, the Ethics, it is possible to notice that for him free human agency implies two interrelated features: on the one hand, the adequate knowledge of the causes that determine it, and, on the other hand, a growing capacity to impact with greater power the scenarios in which it takes place. Thus, in contrast with quietist and passive readings, I show in the following that the two aforementioned characteristics are part of the Spinozian philosophical conception of agency as such. By pursuing this line of thought, it is also possible to establish a link—not always noticed in the secondary literature—with some of the central lines of thought contained in the Theological-Political Treatise. In discussing these theses, I advance the idea that the Spinozian conception of human agency involves a serious readjustment of the metaphysical vision of the agent, a change in her conduct and ethical practices, and an altogether different conception of politics and religion.
Spinoza, Leibniz y el debate acerca de la posibilidad de que dos substancias compartan un mismo atributo. Un aporte a la historia de la lógica y de la metafísica del siglo XVII
Authors: Cortés Juan Vicente
Published: December 2023

El presente trabajo se propone examinar la objeción de Leibniz a E1p2 y E1p5 y responder a ella. La objeción es conocida: es falso, según Leibniz, que dos substancias de atributos diversos no tengan nada en común (i. e., E1p2) y, por consiguiente, que en la naturaleza no puedan darse dos o más substancias de mismo atributo (i. e., E1p5). Defiendo que E1p2 y, por tanto, E1p5 resisten a la objeción de Leibniz. Para ello, abordo, primero, el sentido y la función de E1p2 a fin de determinar dos posibles contextos en que la demostración es válida: el contexto delimitado por la doctrina cartesiana del atributo principal y el contexto escolástico de la doctrina lógica de la diversidad esencial. Segundo, examino la objeción de Leibniz, con lo que determino de manera más precisa el marco epistémico tanto de E1p2d como de la objeción de Leibniz. Tercero, propongo un análisis crítico de la objeción de Leibniz a fin de mostrar que, si bien esta objeción tiene cierta apariencia de validez, si consideramos únicamente lo enunciado por Spinoza en las definiciones y axiomas anteriores a E1p2, esta entraña una contradicción. Por último, indico el punto de mayor dificultad en la demostración de E1p2 para proponer una pequeña rectificación a fin de volverla inmune a la objeción de Leibniz.
Algunas notas sobre la cuestión de la temporalidad en Descartes
Authors: Sibilia Guillermo
Published: December 2023

La cuestión de la temporalidad atraviesa toda la filosofía de Descartes. Es relevante para la geometrización de la física que se propone llevar a cabo, así como también en la misma lógica argumentativa que pone en marcha la duda metódica cartesiana. Sin embargo, Descartes es muchas veces ambiguo en la utilización de los términos “duración”, “tiempo” y “eternidad”. En este artículo estudiamos el estatuto ontológico que tienen esos conceptos e interrogamos el papel que cumplen en la filosofía de Descartes, sobre todo en relación con la física, cuyo fundamento Descartes pretende colocar en la metafísica.
Signum scientis est quod possit docere. L’enseignement de la science selon Thomas d’Aquin
Authors: Valdivia Fuenzalida José Antonio
Published: December 2023

Thomas d’Aquin défend, contre saint Augustin, la thèse selon laquelle l’homme peut enseigner sa propre science à quelqu’un d’autre. Sa théorie sur l’enseignement de la science est développée dans la Somme de théologie, I, q. 117, a. 1 et dans les Questions disputées sur la vérité, q. 11, a. 1. À la lumière de cette doctrine, la présente étude explique pourquoi saint Thomas admet la thèse aristotélicienne du livre I de la Métaphysique selon laquelle la marque distinctive de la science est qu’elle peut être enseignée. On soutient que, selon Thomas, la science peut être enseignée, d’une part, à cause de son caractère dérivatif et, d’autre part, parce qu’elle est fondée sur des principes vrais, évidents et certains.
Clasicismo: génesis y estructura de una idea romántica
Authors: Ruiz de Vergara Olmos Ekaitz
Published: December 2023

La idea de “clasicismo” es una de las categorías más usadas en el mundo de las artes y de la estética filosófica. Sin embargo, la variedad de sus usos ha ocasionado que el término presente dificultades de interpretación y ambigüedades a quienes estudian el arte o la literatura clasicistas. El presente artículo se propone introducir algo de claridad y distinción en la discusión sobre la idea de “clasicismo”. Para ello, nos ocupamos, en primer lugar, de las cuestiones que conciernen a su génesis histórica, disociándolo del concepto parejo, pero esencialmente diferente, de lo clásico. En segundo lugar, ofrecemos una caracterización de su estructura mediante una sistematización de sus cuatro sentidos principales tal y como se usan habitualmente en la bibliografía sobre el tema. De esta forma, el clasicismo se nos presenta como el problema de articular las diferentes conceptualizaciones filosóficas que se han adoptado sobre lo clásico.
Interações entre professor, profissional de apoio escolar e aluno com deficiência intelectual
Authors: Martins Mônica Menin , Dragone Maria Lúcia Oliveira Suzigan
Published: December 2023

Este artigo originou-se de uma pesquisa caracterizada como estudo de caso, locada em uma rede municipal de ensino do interior do estado de São Paulo, desenvolvida em nível de Mestrado na área da Educação. Buscou-se compreender as interações entre professor regente e profissional de apoio escolar do aluno com deficiência intelectual, objetivando identificar como ambos os profissionais descrevem seus papéis e como se relacionam para consolidar o aprendizado do aluno. A pesquisa foi desenvolvida entre 2020 e 2021, com dados coletados através de questionários respondidos remotamente. Os resultados foram analisados de forma qualitativa, contendo relevantes informações do professor sobre sua prática docente e do profissional de apoio escolar sobre sua atuação, indicando dificuldades e fatores que auxiliaram no direcionamento de formações mais específicas sobre uma coparticipação dos profissionais em benefício das necessidades educacionais de alunos com deficiência intelectual.
Desafios e possibilidades da formação de professores para atuar em escolas do campo
Authors: Antunes-Rocha Maria Isabel , Alves Leila de Cássia Faria , Hunziker Adriane Cristina de Melo
Published: December 2023

O artigo apresenta discussões sobre os resultados de nove pesquisas realizadas com estudantes e egressos dos cursos de Licenciatura em Educação do Campo da Universidade Federal de Minas Gerais e da Universidade Federal do Vale do Jequitinhonha e Mucuri. A produção de conhecimentos nestes contextos torna-se relevante tendo em vista que os cursos se constituem como experiência pioneira no atendimento às demandas dos movimentos sociais e sindicais campesinos. Foram selecionados trechos de entrevistas que contêm elementos indicadores da repercussão do processo formativo vivenciado nos cursos em tela. Os dados obtidos foram analisados na perspectiva dos três princípios da Educação do Campo: protagonismo dos sujeitos, a luta pela educação como direito; projeto de escola vinculado a um projeto de campo numa perspectiva sustentável e emancipatória. Os resultados demonstram que os estudantes e egressos estão construindo uma compreensão de si mesmos como sujeitos que lutam para conquistar direitos.
Stress and Coping Strategies among Medical Students in Dubai, United Arab
Emirates, in 2020: A Cross-Sectional Study
Authors: Boushehri Yas K. , Jeyaseelan Lakshmanan , Sultan Meshal A.
Published: December 2023

Background::

Studies conducted worldwide have found that medical students have higher levels of stress than students in other fields. Chronic stress can result in
increased rates of fatigue, depression, and impairment in function. Although this phenomenon has been studied globally, there has been limited
attention in our region. Therefore, the purpose of this study is to assess stress levels in medical students in Dubai and evaluate their coping
strategies to highlight the importance of shedding light on the psychological well-being of this population.

Methods::

A cross-sectional design was utilized for this study. The target population consisted of all medical students enrolled at a local university for the
2020-2021 academic year. The participants completed a survey that collected information on stress and coping strategies. The Perceived Stress
Scale (PSS-10) and the Brief COPE inventory were utilized to gather the data.

Results::

The total of 97 individuals completed the study questionnaire. The rates of high stress levels according to the Perceived Stress Scale (PSS-10) were
higher among medical students in the first to the third year (43.6%), when compared to medical students in the fourth and fifth years (7.7%).
Results of the Brief COPE inventory indicated that the average score for a Problem Focused coping style among medical students fell in the
medium to high range (22 out of 32).

Conclusion::

Levels of stress are elevated among medical students. Coping responses reflect the individual’s psychological adjustment and well-being. Our
study sample revealed a medium to high rate of engagement in healthy coping strategies. Future research that evaluates the psychological impact of
stress in-depth and explores effective strategies to enhance coping is highly warranted.
One-Dimensional Topological Insulators
Authors: Rizwan M.
Published: December 2023

One-dimensional topological insulators have garnered quite a lot of attention in recent times. These topological insulators (TIs) are crucial in the comprehension of topological properties. This chapter provides a very detailed and comprehensive overview of these astonishing materials. From history, classification based on symmetry, Dirac points, and dimensions, generations such as 1st, 2nd, and higher order TIs, synthesis techniques such as physical vapor deposition, chemical vapor deposition, 2D, 3D Tis and future models of these topological insulators, all are deliberated in detail. Future aspects are discussed as well, this chapter is composed to fully enlighten the reader on these 1D topological insulators.
Topological Superconductor
Authors: Rizwan M.
Published: December 2023

In the scientific community, in topological materials superconductivity has attracted scientists significantly as Majorana fermions as observed in these materials perceived from zero-biased conduction peak, quantized thermal conductivity, and AJE (Anomalous Josephson Effect). In this chapter recent advancements in the field of TSCs have been discussed. Role Majorana fermions in TSCs has been discussed briefly. Few materials that show topological superconductivity under specific conditions have also been considered. Unconventional doping-based sed superconductors showed topological superconductivity having topological invariant states in the form of bulk from under certain conditions.
Topological Insulators for Mode-Locked Fiber Lasers
Authors: Urossha S.
Published: December 2023

In this chapter, topological insulator materials such as graphene and bismuth telluride (Bi2Te3) as saturable absorbers (SA) are discussed experimentally in erbium and ytterbium-doped mode-lock fiber lasers. Ultra-short pulses at various wavelengths can be produced by modifying the crystal structures of topological insulators (TIs). This chapter provides a detailed explanation of how TIs can be created and incorporated as effective passive saturable absorbers with different fiber mode-lock lasers capable of providing basic to high-harmonic pulse production. The function of mode-locking in Er and Yb-doped fiber lasers is described experimentally by making use of various fabrication methods and optical characterizations are also discussed. The findings show that fiber-laser saturable absorbers comprised of Bi2Te3 and graphene have the potential to be utilized in powerful mode-locked fiber laser technologies.
Applications of MXenes in Supercapacitors
Authors: Buragohain A.
Published: December 2023

In search of eco-friendly, low-cost, highly efficient energy materials to fulfil the global energy need, the research community from all over the world has explored a novel two-dimensional material called MXene. The term 'MXene’ refers to a class of materials with very unique features including large surface area, high conductivity, etc., that could be used as the electrode material to fabricate highly efficient supercapacitors with high power density. Moreover, the composites made of MXene with some metal oxides, conducting polymers, and carbon-based materials exhibit very good electrochemical properties as electrode materials of supercapacitors.
Człowiek sformatowany
Authors: Kois Magdalena
Published: December 2023

Współczesna inżynieria społeczna wykorzystuje wszelkie dostępne narzędzia do stworzenia nowego modelu człowieka. Jest nim jednostka zrelatywizowana moralnie, podlegająca prawom rynku i znakomicie przystająca do narzuconych globalnie reguł życia. Kompresja czasu i przestrzeni jako wynik gwałtownego rozwoju technologii prowadzi do zatracenia się w teraźniejszości. Pomysł stworzenia człowieka ,,na teraz” dostosowanego do aktualnej rzeczywistości zawiera w sobie jednak także perspektywę przyszłości. Człowiek sformatowany będzie mógł wpasować się zawsze w to, co nowe. Bez moralnych zasad, odniesienia do jakiekolwiek tradycji będzie w stanie wtopić się w każde środowisko życia i funkcjonować według panujących w nim reguł.
Teologiczna ocena moralna cywilizacji naukowo-technicznej w świetle nauki Jana Pawła II
Authors: Rel Małgorzata
Published: December 2023

„Człowiek dzisiejszy zdaje się być stale zagrożony przez to, co jest jego własnym wytworem, co jest wynikiem pracy jego rąk, a zarazem – i bardziej jeszcze – pracy jego umysłu, dążeń jego woli. Owoce tej wielorakiej działalności człowieka (…), w jakimś pochodnym i pośrednim zakresie skutków – skierowują się przeciw człowiekowi.” (Jan Paweł II). Papieski postulat domagający się proporcjonalnego do rozwoju cywilizacji naukowo – technicznej, rozwoju moralności i etyki, wskazuje na możliwe postawy współczesnego człowieka inspirowane antropologią chrześcijańską. Na przykładzie encyklik Redemptor Hominis i Fides et Ratio Jana Pawła II, chciałabym przedstawić rozważania dotyczące relacji człowieka wobec rozwoju cywilizacji naukowo – technicznej oraz zastanowić się: „czy człowiek jako człowiek, w kontekście tego postępu staje się lepszy, (…) bardziej gotowy świadczyć i nieść pomoc wszystkim?”.
Conocimiento en salud sexual y reproductiva en estudiantes de la Unidad Educativa “Roberto Arregui” Guaranda. 2023.
Authors: Mas Camacho María Rosa , López Paredes Silvana Ximena , Camacho Suárez Marcelo Sebastián , Galarza Lara Bryan Joel
Published: December 2023

La educación sexual es de vital importancia como prevención a conductas de riesgo, siendo la adolescencia una etapa crucial de la vida respcto al conocimiento de enfermedades por transmisión sexual y planificación familiar, que le aporta madurez y responsabilidad como ser social. Se expone en la presente el Proyecto de Vinculación efectuado en una Unidad Educativa de Guaranda, Bolívar, la cual tuvo por objetivo desarrollar acciones educativas sobre salud sexual y reproductiva con los estudiantes. Es un estudio cuantitativo trasversal, con una muestra intencionada de 140 alumnos de 14 años de edad, o superior. Se identifica a partir de la encuesta aplicada, el predominio en el criterio de la preferencia a la familia como fuente para la orientación e información sobre la sexualidad y la existencia de un conocimiento medio sobre métodos anticonceptivos y de infecciones de trasmisión sexual. Los proyectos educacionales que promuevan estilos de vida saludables sobre la educación sexual y reproductiva, se fortalecen con la integración del personal docente, profesionales de la salud y las familias.

Palabras clave: adolescente; comportamiento sexual; educación sexual; salud sexual
Respons Pertumbuhan dan Hasil Produksi Pegagan pada Pemberian Pupuk Organik Cair dan Pupuk Kandang Sapi
Authors: Firgiyanto Refa , Antika Hermin , Elfina Vera , Kusparwanti Tri Rini , Rohman Hanif Fatur , Siswadi Edi , Sukri M. Zayin
Published: December 2023

Tanaman pegagan merupakan tanaman yang memiliki banyak manfaat untuk kesehatan sebagai tanaman obat, sehingga diperlukan upaya untuk meningkatkan produktivitas tanaman. Salah satu upaya yang dilakukan antara lain perbaikan teknik budidaya melalui penambahan pupuk organik. Tujuan penelitian yaitu untuk mengetahui pengaruh tunggal dan interaksi pemberian konsentrasi pupuk organik cair bonggol pisang dan dosis pupuk kandang sapi. Penelitian dilakukan di Screen house Laboratorium Tanaman, Politeknik Negeri Jember (89 mdpl).  Penelitian ini menggunakan Rancangan Acak Kelompok (RAK) Faktorial. Faktor pertama adalah konsentrasi pupuk organik cair 0, 50, dan 100 ml/l dan faktor kedua yaitu dosis pupuk kandang 0, 200, dan 400 g/polybag. Variabel pengamatan pada penelitian ini antara lain jumlah daun, jumlah stolon, jumlah anakan, panjang stolon terpanjang, panjang tangkai terpanjang, berat basah tanaman, berat kering tanaman, berat akar tanaman, kandungan klorofil tanaman, dan kandungan flavonoid tanaman pegagan. Hasil penelitian menunjukkan bahwa faktor tunggal pemberian POC belum berpengaruh secara nyata pada seluruh variabel pengamatan sedangkan pemberian pupuk kandang sapi mampu meningkatkan secara nyata panjang tangkai tanaman pegagan dengan dosis terbaik pada perlakuan 200 dan 400 g/polybag. Interaksi pemberian konsentrasi POC dan pupuk kandang berpengaruh nyata pada variabel jumlah daun 2 dan 4 MST, panjang stolon, dan berat akar tanaman. Pemberian terbaik didapatkan pada perlakuan pemberian POC 100 ml/l dan dosis pupuk kandang sapi 200 g/polybag.
Analisis Pektin dan Vitamin C untuk Evaluasi Sifat Tahan Simpan pada Generasi F2 Buah Cabai LB
Authors: Izi Muhammad Nur , Chairunisa Chairunisa , Wahyuni Wahyuni , Herliana Lina , Seftiono Hermawan
Published: December 2023

Cabai (Capsicum annuum L.)  merupakan salah satu komoditas sayuran terpenting dan strategis di Indonesia. Sebagai salah satu komoditas terpenting, cabai memiliki masa simpan pascapanen yang relatif singkat yang seringkali menjadi penyebab kerugian ekonomi. Ketahanan daya simpan cabai dapat ditingkatkan melalui upaya persilangan. Persilangan antara dua varietas cabai, Laris (daya hasil tinggi) dan SSP (tahan simpan) telah menghasilkan generasi kedua (F2) cabai LB. Buah cabai F2 LB matang merah telah dikelompokkan berdasarkan daya simpannya, dilihat dari susut bobot buah pascapanen. Pada studi ini, dilakukan pengukuran kandungan pektin dan vitamin C pada buah cabai F2 LB matang merah. Pektin dan vitamin C merupakan bagian komponen struktural dan antioksidan penjaga keutuhan dinding sel yang penting untuk ketahanan simpan buah. Tujuan penelitian adalah menyelidiki korelasi antara kandungan pektin atau vitamin C dengan sifat ketahanan simpan buah cabai. Analisis juga dilakukan pada buah cabai tetua Laris dan SSP sebagai kontrol. Pengukuran pektin dilakukan menggunakan Pectin Identification Kit (Megazyme) dengan dua protokol tambahan. Kandungan pektin dan vitamin C diukur secara semi kuantitatif menggunakan spektrofotometer. Hasil menunjukkan bahwa kandungan pektin dan vitamin C pada buah cabai F2 LB tidak berbeda signifikan antara yang tahan simpan dengan yang tidak tahan simpan, maupun dengan kedua tetuanya. Hasil ini mengindikasikan bahwa variasi ketahanan simpan yang teramati pada sampel buah cabai tidak bergantung pada kandungan pektin maupun vitamin C. Kami menduga bahwa aktivitas enzimatik, terutama yang terlibat dalam proses degradasi komponen dinding sel, lebih berperan dalam menentukan sifat ketahanan simpan cabai.
Pemupukan Silikon dalam Meningkatkan Pertumbuhan dan Hasil Tanaman Sorgum
Authors: Amin Mirawanty , Mulyawan Ronny , Santari Putri Tria , Manwan Sri Wahyuni , Prasetyo Rahadian Adi
Published: December 2023

Penggunaan Silikon (Si) secara terus-menerus tanpa adanya input pemupukan dapat menyebabkan Si tersedia di dalam tanah semakin menurun. Kandungan Si yang rendah dapat menjadi faktor pembatas suatu tanaman terhadap penurunan hasil. Silikon merupakan beneficial element yang sangat dibutuhkan oleh sorgum terhadap pertumbuhannya. Sorgum merupakan tanaman alternatif yang baik terutama di daerah kering, sehingga sorgum sering mengalami cekaman defisit air. Penggunaan Si dapat menurunkan efek bahaya dari cekaman biotik seperti hama dan penyakit, dan cekaman abiotik seperti salinitas, kekeringan, defisiensi hara, dan logam berat. Pentingnya Si pada tanaman menjadi perhatian bagi para peneliti untuk menghasilkan penelitian tentang pemupukan Si pada tanaman. Nanoteknologi merupakan teknik pemupukan ramah lingkungan yang saat ini dikembangkan karena sifatnya yang efisien, ramah lingkungan, dan berkelanjutan. Akan tetapi, masih banyak yang belum mengetahui tentang peran Si pada tanaman, sumber Si, dan pemupukan Si pada sorgum. Sehingga diperlukan informasi secara menyeluruh terkait peran Si hingga pemupukan pada sorgum.