bluuebunny/crossref_metadata_2025 huggingface dataset:
A scoping review of randomized trials assessing the impact of n-of-1 trials on clinical outcomes
Authors: Samuel Joyce P. , Wootton Susan H. , Holder Travis , Molony Donald
Published: June 2022

Background

The single patient (n-of-1) trial can be used to resolve therapeutic uncertainty for the individual patient. Treatment alternatives are systematically tested against each other, generating patient-specific data used to inform an individualized treatment plan. We hypothesize that clinical decisions informed by n-of-1 trials improve patient outcomes compared to usual care. Our objective was to provide an overview of the clinical trial evidence on the effect of n-of-1 trials on clinical outcomes.

Methods

A systematic search of medical databases, trial registries, and gray literature was performed to identify trials assessing clinical outcomes in a group of patients undergoing an n-of-1 trial compared to those receiving usual care for any clinical condition. We abstracted elements related to study design and results and assessed risk of bias for both the overall randomized trials and the n-of-1 trials. The review was registered on PROSPERO. (CRD: 42020166490).

Findings

Twelve randomized trials of the n-of-1 approach were identified in conditions spanning chronic pain, osteoarthritis, chronic irreversible airflow limitation, attention-deficit hyperactivity disorder, hyperlipidemia, atrial fibrillation, statin intolerance, and hypertension. One trial showed a statistically significant benefit in the primary outcome. Only one reached the pre-specified sample size target. Secondary outcomes showed modest benefits, including decreasing medication use, fewer atrial fibrillation episodes, and improved patient satisfaction.

Interpretation

Very few trials have been undertaken to assess the effectiveness of n-of-1 trials in improving clinical outcomes, and most trials were underpowered for the primary outcome. Barriers to enrollment and retention in these trials should be explored, as well-powered randomized trials are needed to clarify the clinical impact of n-of-1 trials and assess their utility in clinical practice.
Super high-resolution single-molecule sequence-based typing of HLA class I alleles in HIV-1 infected individuals in Ghana
Authors: Nii-Trebi Nicholas I. , Matsuoka Saori , Kawana-Tachikawa Ai , Bonney Evelyn Y. , Abana Christopher Z. , Ofori Sampson B. , Mizutani Taketoshi , Ishizaka Aya , Shiino Teiichiro , Ohashi Jun , Naruse Taeko K. , Kimura Akinori , Kiyono Hiroshi , Ishikawa Koichi , Ampofo William K. , Matano Tetsuro
Published: June 2022

Polymorphisms in human leukocyte antigen (HLA) class I loci are known to have a great impact on disease progression in HIV-1 infection. Prevailing HIV-1 subtypes and HLA genotype distribution are different all over the world, and the HIV-1 and host HLA interaction could be specific to individual areas. Data on the HIV-1 and HLA interaction have been accumulated in HIV-1 subtype B- and C-predominant populations but not fully obtained in West Africa where HIV-1 subtype CRF02_AG is predominant. In the present study, to obtain accurate HLA typing data for analysis of HLA association with disease progression in HIV-1 infection in West African populations, HLA class I (HLA-A,-B, and-C) four-digit allele typing was performed in treatment-naïve HIV-1 infected individuals in Ghana (n = 324) by a super high-resolution single-molecule sequence-based typing (SS-SBT) using next-generation sequencing. Comparison of the SS-SBT-based data with those obtained by a conventional sequencing-based typing (SBT) revealed incorrect assignment of several alleles by SBT. Indeed, HLA-A*23:17, HLA-B*07:06, HLA-C*07:18, and HLA-C*18:02 whose allele frequencies were 2.5%, 0.9%, 4.3%, and 3.7%, respectively, were not determined by SBT. Several HLA alleles were associated with clinical markers, viral load and CD4+T-cell count. Of note, the impact ofHLA-B*57:03andHLA-B*58:01, known as protective alleles against HIV-1 subtype B and C infection, on clinical markers was not observed in our cohort. This study for the first time presents SS-SBT-based four-digit typing data onHLA-A,-B, and-Calleles in Ghana, describing impact of HLA on viral load and CD4 count in HIV-1 infection. Accumulation of these data would facilitate high-resolution HLA genotyping, contributing to our understanding of the HIV-1 and host HLA interaction in Ghana, West Africa.
The small nonstructural protein NP1 of human bocavirus 1 directly interacts with Ku70 and RPA70 and facilitates viral DNA replication
Authors: Ning Kang , Wang Zekun , Cheng Fang , Yan Ziying , Qiu Jianming
Published: June 2022

Human bocavirus 1 (HBoV1), a member of the genusBocaparvovirusof the familyParvoviridae, causes acute respiratory tract infections in young children. Well-differentiated pseudostratified human airway epithelium cultured at an air-liquid interface (HAE-ALI) is an idealin vitroculture model to study HBoV1 infection. Unique to other parvoviruses, bocaparvoviruses express a small nonstructured protein NP1 of ~25 kDa from an open reading frame (ORF) in the center of the viral genome. NP1 plays an important role in viral DNA replication and pre-mRNA processing. In this study, we performed an affinity purification assay to identify HBoV1 NP1-inteacting proteins. We identified that Ku70 and RPA70 directly interact with the NP1 at a high binding affinity, characterized with an equilibrium dissociation constant (KD) of 95 nM and 122 nM, respectively. Furthermore, we mapped the key NP1-interacting domains of Ku70 at aa266-439 and of RPA70 at aa181-422. Following a dominant negative strategy, we revealed that the interactions of Ku70 and RPA70 with NP1 play a significant role in HBoV1 DNA replication not only in anin vitroviral DNA replication assay but also in HBoV1-infected HAE-ALI cultures. Collectively, our study revealed a novel mechanism by which HBoV1 NP1 enhances viral DNA replication through its direct interactions with Ku70 and RPA70.
The water industry and the decarbonisation of cities: A comprehensive review in the context of Cop26
Authors: Fisher Peter M. J. , Smith David
Published: June 2022

The urban water industry is a very energy intensive industry. Higher water quality standards are driving a level of energy growth that is threatening to move it to the top rank. Climate change is further exacerbating this situation: Growing aridity is variously imposing an enhanced carbon burden through water recycling, trans-regional pipelines and desalination plants. Natural disasters too can often affect water quality, requiring energy hungry mitigations. There’s clear evidence that a failure to appropriately weight energy considerations in water infrastructure is commonplace and that this is an unsustainable position for the industry and is prejudicial to working towards zero carbon cities targeting net zero by 2030. Real time tracking of CO2e emissions is an important starting point in raising operator consciousness and introducing rivalry between utilities in attaining abatement. So too is reaching out to the resource and manufacturing sectors to form strategic alliances, as well as seeking to enter into closer relationships with the energy sector.
‘Moving to Heal’: A holistic approach to well-being through Nia dance
Authors: Oliver Sue , Small Karen
Published: June 2022

This narrative account of a Nia dance class describes its origin and application, highlighting the teacher’s experience of giving and receiving in the course of delivering a class and the participant’s perception of its effect on mind and body.

Firstly, the authors consider the neurological and physiological aspects of Nia and the link to social and emotional factors which constitute well-being. The teacher then explains how she became involved with Nia and the motivation behind her teaching – what she gives and what, in turn, she feels she gains. She then describes one application of Nia, ‘Moving to Heal’, explaining how it can increase dancers’ awareness of their own bodies and thoughts, and gives them permission to let go of these thoughts, which bind them and inhibit the exploration of movement in a guided and safe manner.

Following on from that, one dancer explores her experience of ‘Moving to Heal’. She explains how this holistic practice generates for her, feelings of well-being through physical, mental and spiritual engagement with the movement and music.

The article concludes by reflecting on how the practice of Nia links with the theory as it is experienced through ‘Moving to Heal’.
The reception of American and French film noir in post-war Greece, 1945–58
Authors: Papadopoulos Leonidas , Poupou Anna , Stefani Eva
Published: June 2022

The aim of this article is to examine the distribution, promotion and critical reception of American and French film noir in Greece from 1944 to 1958 and to shed light to the reasons of the belated appearance of Greek noir examples. It is based on archival research that was made in the framework of the project ‘Film noir in Greece: Reception, assimilation, and imitation of a US film genre, from the post-war period until today’ (National & Kapodistrian University of Athens), financed by the Operational Programme Human Resources Development, Education and Lifelong Learning, P.A. 2014–20. Crime thrillers that were retrospectively labelled as film noirs, were not only known and enjoyed by the Greek public from 1945 onwards, but also their conventions and imagery were used in the journalistic discourse, showing a wider diffusion to society that was not only limited to communities of cinephiles. From this perspective, we examine the vocabulary and terminology invented and established by Greek reviewers and distributors, in order to describe the key features of the films that today we classify as film noir. We discuss how emblematic films that today form the canon of film noir were received at that time, as well as the negative discourses that appear at the same time in the public sphere, especially around issues of ‘moral panic’, violence and delinquency. Furthermore, the distinction in the reception of French vs. American films enables us to apprehend the different ideological stances towards these films and to understand why French crime films were more influential in Greece than their American counterparts.
Antonia Cruseis y Antonius Ursianus: dos hermanos de leche en Augusta Emerita
Authors: Cidoncha Redondo Francisco
Published: June 2022

Los hermanos de leche o conlactei fueron figuras bastante frecuentes en la sociedad romana a juzgar por el importante número de testimonios escritos conservados. Las fuentes epigráficas, jurídicas o literarias, entre otras, nos ofrecen interesantes datos sobre las relaciones de estas personas que fueron alimentadas por una misma mujer durante sus primeros años de vida. El papel desempeñado por la nutrix fue fundamental en estos casos. A veces, las nodrizas eran esclavas que tenían sus propios hijos y, además, tuvieron que encargarse de la lactancia de los descendientes de sus propietarios o de los hijos de otros esclavos. De esa forma, nos encontramos con hermanos de leche que tenían diferentes orígenes sociales, algunos de ellos eran esclavos y otros libres. A lo largo de las siguientes páginas nos centraremos en el ejemplo documentado en la inscripción funeraria de Antonia Cruseis, procedente de Augusta Emerita (Lusitania). El presente caso de estudio nos proporciona una gran cantidad de información y nos demuestra que el fuerte vínculo que se forjó entre los hermanos de leche no se rompía cuando terminaba la infancia y superaba barreras sociales. Esos lazos casi fraternales entre Antonia Cruseis y Antonius Ursianus quedaron atestiguados como un dato digno de aparecer en el epitafio de la primera, fallecida ya siendo una mujer adulta. A continuación analizaremos las relaciones familiares existentes entre estos dos conlactei, el papel del viudo como dedicante del epígrafe y el estudio de la nutrix que constituyó el nexo de unión entre Cruseis y Ursianus.
Vértigo (1958) de Hitchcock: la utilización del cromatismo en la descripción de patologías médicas de los personajes
Authors: Ramón Fernández Francisca
Published: June 2022

Una de las películas más emblemáticas de la filmografía de Alfred Hitchcock es Vértigo (1958), y que junto con Psicosis (1960) su título se corresponde con una enfermedad, en concreto del sistema vestibular. Se trata de un adaptación cinematográfica de la novela de Sueurs froides: d´entre les morts, de Pierre Boileau y Thomas Narcejac. En esta película se utiliza el color como recurso cinematográfico para identificar a los personajes y también sus enfermedades. Colores primarios como el rojo, azul y amarillo se corresponden con el vértigo, el mareo la acrofobia, y la limerencia, así como trastornos del sueño; y los secundarios como el verde y el gris con los trastornos de la personalidad y conductas autodestructoras directas o conscientes. Nos proponemos analizar la asociación de colores, su fusión y combinación en las enfermedades que sufren los personajes y que se identifican por la percepción cromática que domina todo el filme.
Las múltiples dimensiones de la salud y enfermedad del ser ecobiopsicosocial en Un monstruo viene a verme (2016)
Authors: Ríos-Covián Molina Xavier , Canto-Costal Ana Cecilia , Romero-Moguel Andrea , Guillermo-Herrera Jorge Carlos , Cáceres-Castro Francisco Javier , Méndez-Domínguez Nina
Published: June 2022

Connor O’Malley es un chico de 12 años que padece del síndrome del cuidador debido a la enfermedad terminal de su madre; sus temores se materializan y cobran vida constituyendo de manera fantástica un temible monstruo que tiene como propósito sacar a la luz sus más profundos temores y sentimientos. Todo paciente con enfermedad terminal al dejar de ser independiente requiere atención de cuidadores que aseguren su bienestar y en muchas ocasiones los cuidadores son miembros de la familia. El síndrome del cuidador es una condición provocada por el cuidado extenuante de un familiar dependiente. Este síndrome se manifiesta en respuesta a un estrés emocional y se caracteriza por el agotamiento tanto físico como psicológico. Al constituirse como una entidad ecobiopsicosocial, la salud humana es resultado del bienestar en cada esfera, de modo que, cuando existe afectación de tan solo una de ellas, la salud de un individuo puede afectarse, como sucede en el síndrome del cuidador. El síndrome del cuidador en Connor es el tema del presente artículo, así como lo son los potenciales medios para su abordaje.
Murmullos en la ciudad. Humanización médica en clave de comedia romántica
Authors: D’Ottavio Callegari María Eugenia , D’Ottavio Callegari María Silvia , D’Ottavio Cattani Alberto Enrique
Published: June 2022

Este filme se enfoca en parte de la historia de un médico según se expresa inicialmente en un escrito sobrepuesto Tal profesional es fundador de una clínica donde se aborda a los pacientes humanizada e integralmente. Aunque carece del carácter épico de otras producciones cinematográficas sobre médicos y Medicina, lo humanitario sobrevuela de manera constante a lo largo de la trama. Además, siendo una comedia romántica dramática no evita trata algunos temas polémicos para el entonces vigente macartismo anticomunista.La susodicha humanización médica y este plus subyacente en una ficción apriorísticamente ligera estimuló y guio la redacción de este trabajo.
THE POTENTIAL FOR THE DEVELOPMENT OF CONSUMER COOPERATION IN DAIRY CATTLE BREEDING IN THE REGION
Authors: Vorobyov S. P. , Vorobyova V. V. , Titova O. V.
Published: June 2022

The article provides a literary review of the development of consumer cooperation in milk production, identifies municipalities of the Altai Territory with different potential for the development of cooperation of small forms of management in dairy cattle breeding. It is shown that in conditions of a decrease in the number of cows in all categories of management, the proportion of municipalities in the region with the highest and highest potential for the development of consumer cooperation increases. The activity of six agricultural consumer cooperatives in certain rural areas of the region does not allow for the coverage of consumer cooperation in most of the municipal districts with a high potential for the development of joint activities of small business entities in the field of milk production. It is noted that consumer cooperation in agriculture develops only with state support and the presence of initiative entrepreneurs, and in areas with a suitable agrarian structure for the formation of non-profit associations of milk producers, it is still necessary to develop the necessary infrastructure, conduct organizational and educational work.
ASSESSMENT OF PROFITABILITY AND TAX BURDEN OF AGRICULTURAL ENTERPRISES AS PART OF AGRICULTURAL HOLDINGS
Authors: Savchenko A. S.
Published: June 2022

The purpose of the study was to identify the differentiation of profitability and tax burden of legally independent agricultural organizations and organizations within agricultural holdings, as well as to determine the influence of a number of factors on the change in profitability and the level of tax burden. The article analyzes the dynamics of profitability and tax payments of agricultural organizations of the Altai Territory. During the research, data on the amount of taxes, fees and insurance payments paid by agricultural enterprises of the Altai Territory, depending on their membership in agricultural holdings, were summarized, and an assessment of the tax burden of these enterprises was given. It is established that the tax burden of agricultural organizations that are part of agricultural holdings is higher than the tax burden of legally autonomous organizations, which is primarily due to the specialization of economic entities. The profitability of agricultural enterprises’ production was also determined by the structure of their marketable products. It is noted that the revenue and the amount of taxes and fees to varying degrees have an impact on the tax burden of organizations that are part of agricultural holdings and legally autonomous enterprises.
ON THE CRISIS OF PAYMENT FOR TRAINERS OF SPORTS SCHOOLS: INVITATION TO DISCUSSION
Authors: Samsonov I. I. , Popova N. V.
Published: June 2022

The article is devoted to the study of the procedure for the formation of standard costs for the remuneration of the coaching staff in relation to the applied systems of remuneration of their labor. The authors, having studied the issue of the systems of remuneration used, come to the conclusion about the enormous popularity of the “group” system, but the partial use of the “hourly”, “capitation”, “rating” system of remuneration. The study of the procedure for the formation of standard costs for the wages fund indicates a devaluation of the standard costs for wages of trainers to 72.5%, which is explained by insufficient consideration of the conditions of the external and (or) internal environment of the organization. In the context of the harmonization of legislation carried out in the country, the authors proposed to restructure the procedure for determining the normative costs, taking into account the identified contradictions, taking into account: 1) revision of the allocation of independent work as a mandatory form of organizing the training process, 2) unification of the duration of the lesson regardless of the type of economic activity of the program being implemented, 3) special the nature of the work of coaches, 4) the peculiarities of recruiting groups of sports training, 5) the need to revise the classification of sports training services.
Efficacy and Safety of Infliximab Retreatment in Crohn's Disease: A Multicentre, Prospective, Observational Cohort (REGAIN) Study from the GETAID
Authors: Boschetti Gilles , Nachury Maria , Laharie David , Roblin Xavier , Gilletta Cyrielle , Aubourg Alexandre , Bourreille Arnaud , Zallot Camille , Hebuterne Xavier , Buisson Anthony , Grimaud Jean-Charles , Bouhnik Yoram , Allez Matthieu , Altwegg Romain , Viennot Stéphanie , Vuitton Lucine , Carbonnel Franck , Paul Stéphane , Desseaux Kristell , Lambert Jérome , Peyrin-Biroulet Laurent
Published: June 2022

INTRODUCTION:

The objective of this study was to describe the efficacy and safety of infliximab (IFX) reintroduction in Crohn's disease (CD) after stopping for loss of response or intolerance.

METHODS:

We conducted a prospective multicenter observational cohort study including adult patients with clinically (CD Activity Index >150) and objectively active luminal CD in whom IFX was reintroduced after at least 6 months of discontinuation. The reasons for the initial discontinuation could be a secondary loss of response or IFX intolerance. The reintroduction schedule included 3 IFX infusions at weeks 0, 4, and 8, after a systematic premedication. The primary end point was the efficacy of IFX retreatment at week 26 defined by a CD Activity Index of <150 in the absence of IFX discontinuation or use of corticosteroids, surgery, or other biologic.

RESULTS:

At week 26, 24 patients (35%) among the 69 analyzed reached the primary end point. No significant difference was observed between rates of clinical remission at week 26 in patients with prior LOR (n = 48) and those with IFX intolerance (n = 21) (35% and 33%, P = 0.87, respectively). Thirty-two acute infusion reactions were recorded in 27 patients, leading to withdrawal of IFX in 20 patients. No pharmacokinetic characteristic at baseline but detection of positive anti-drug antibodies at week 4 was predictive of IFX failure or infusion reaction at week 26.

DISCUSSION:

In this first prospective cohort study, IFX retreatment was safe and effective in one-third of the patients with CD, regardless the reason of prior discontinuation. Early detection of anti-drug antibodies can predict subsequent IFX reintroduction failure and infusion reactions.
Extração da Informação Posicional de Pontos de Projeção Cartográfica Geradas em Rotinas de Processamento para Geração de Ortofotos
Authors: Alves Junior Agostinho Prado , Gomes Luciano Nardini
Published: June 2022

As aeronaves remotamente pilotada (RPA) têm sido amplamente utilizadas na geração de ortofotos e modelos digitais de elevação (MDE), que subsidiam as análises geoespaciais. Ocasionalmente, estas análises requerem levantamentos rápidos, o que inviabiliza o uso de RPA associado a pontos de apoio para a correção da posição, ajuste e avaliação da qualidade dos ortofotos e MDE. Atualmente é possível a geração automatizada destes produtos por meio do uso de rotinas preestabelecidas disponíveis em programas especializados na manipulação das imagens obtidas com RPA. Dessa forma, a presente pesquisa se justifica pela carência de análises efetivas do processamento de imagens coletadas com RPA, em que poderá contribuir metodologicamente com a qualidade do mapeamento. Portanto, o objetivo deste trabalho foi extrair a informação posicional de pontos de projeção cartográfica geradas em rotinas de processamento para a geração de ortofotos no software Agisoft Metashape. Após o processamento das imagens, os resultados com ambas rotinas se mostraram satisfatórias para extração das informações geográficas, porém apenas as rotinas de alto rigor de qualidade se mostram como uma importante ferramenta no auxílio na atualização cadastral. Contudo, para o mapeamento de áreas rurais o processamento pode ser realizado nas cinco rotinas de processamento (Lowest, Low, Medium, High e UltraHigh).
Modelagem Dinâmica Espacial das Mudanças de Uso e Cobertura da Terra na Região Hidrográfica da Baía da Ilha Grande-RJ: um Enfoque Sobre Comunidades Tradicionais e Unidades de Conservação
Authors: Branco Teule Lemos , Almeida Cláudia Maria de , Francisco Cristiane Nunes
Published: June 2022

O objetivo deste trabalho é analisar a influência das Unidades de Conservação (UCs) e das comunidades tradicionais no processo de mudança de uso e cobertura da terra na Baía da Ilha Grande ao longo dos anos de 2013 a 2018, por meio de modelagem dinâmica espacial. Para realizar a modelagem, foi utilizada a plataforma Dinamica EGO, que realiza simulação do uso e cobertura da terra com o método de pesos de evidência e é baseada no paradigma de autômatos celulares. Foi realizada a simulação espacial para doze unidades hidrológicas de planejamento, dando-se ênfase à observação das taxas de transição e aos pesos atribuídos para as variáveis de UCs e comunidades tradicionais. Nas UCs de Proteção Integral, foi observado um padrão de pesos negativos para as transições de desflorestamento e urbanização, ao passo que as UCs de Uso Sustentável indicam pressão antrópica sobre os ambientes naturais costeiros. As comunidades tradicionais apresentam dinâmicas próprias em seus territórios, sendo observado que os mesmos desfavorecem a urbanização no interior de seus limites. O modelo de Bayes foi capaz de simular os processos de mudança de uso e cobertura na área de estudo, e os resultados por ele produzidos podem ajudar na gestão da mesma. Os pesos atribuídos para as variáveis categóricas de UCs revelam como estas se comportam para determinadas transições, e as simulações por eles ajustadas produziram Índices de Similaridade Fuzzy satisfatórios. Este trabalho permitiu o entendimento das dinâmicas que ocorrem no interior de UCs e comunidades tradicionais, o que poderá auxiliar na elaboração de diretrizes para o planejamento territorial e ambiental.
Implantação de uma Base de Classificação da Componente Angular de Estações Totais e Teodolitos em Laboratório com Uso de Colimadores
Authors: Silva Josevando Sousa , Faggion Pedro Luis , Soria Medina Alex
Published: June 2022

É cada vez mais necessário que processos usados em instrumentação geodésica sejam automatizados, visando a eficiência e redução de tempo de execução. No Brasil e no mundo há diversas normativas que se atém a esta temática, estabelecendo os procedimentos em campo e laboratório para a classificação da componente angular de instrumentos geodésicos. É neste contexto que esta pesquisa projetou e implantou um sistema de classificação da componente angular horizontal de teodolitos e estações totais em laboratório, conjuntamente com a automação do processo de cálculo e emissão de certificado de classificação. Para viabilizar essa proposta, foi reproduzida a mesma condição estabelecida pela NBR 13133/1994 (atualizada em 2021), para uma base de classificação de campo, porém em laboratório, utilizando colimadores para a definição de pontos que serão ocupados pelos alvos (visados). Estes colimadores foram instalados em uma plataforma de concreto, todos no mesmo plano horizontal, de forma que o ângulo horizontal formado entre o primeiro colimador e o último, foi maior que noventa graus. Para garantia da manutenção do mesmo plano horizontal utilizou-se um nível geodésico N3 da Wild. Ao final do processo de coleta de dados (após leituras/medições), estes dados foram inseridos de forma manual pelo operador ou por meio de upload de arquivo com extensão .txt, realizando por meio do MATLAB® (MATrix LABoratory), os cálculos oriundos da Norma e que resultou na emissão automática de um certificado de classificação da componente angular horizontal do instrumento.
Análise Comparativa da Acurácia Posicional Proporcionada por Plataformas de Processamento de Dados GPS no Posicionamento Relativo e por Ponto Preciso
Authors: Ferreira Raissa Cruz , Carvalho Alessandro Salles , Cioce Victor Jose , Fonseca Junior Edvaldo Simões da
Published: June 2022

Vários serviços de processamento de dados GPS (Global Positioning System) estão disponíveis em plataformas on-line para determinação posicional com uso dos métodos relativo e por ponto preciso (PPP). Devido à gratuidade, facilidade de manuseio e fornecimento de resultados robustos, muitos usuários têm submetido dados GPS coletados em campo para o cálculo das coordenadas geodésicas dos pontos de interesse. O Software Bernese GNSS v.5.2 (BSW) e os serviços/plataformas AUSPOS, IBGE-PPP, CSRS-PPP (SPARK) e OPUS foram utilizados para o processamento das observáveis GPS coletadas em 30 marcos geodésicos, com sessões de observação de 5h, para determinação das coordenadas. Uma análise comparativa da qualidade posicional proporcionada por cada estratégia foi realizada. As discrepâncias posicionais foram calculadas tomando como referência as coordenadas obtidas com uso do Software Bernese no modo Relativo. Os resultados indicam acurácia posicional centimétrica (0,016 m a 0,073 m) para as componentes altimétrica, planimétrica e tridimensional para uso do AUSPOS, BSW-PPP, IBGE-PPP, CSRS-PPP e decimétrica (0,100 m a 0,180 m) para o OPUS, indicando deste modo, potencialidades dos serviços. A plataforma que proporcionou maior concordância posicional em relação aos resultados obtidos pelo BSW- relativo foi o CSRS-PPP (SPARK), seguido pelo AUSPOS, BSW-PPP, IBGE-PPP e OPUS.
Towards a Robust Approach for Multitemporal Landcover Dataset: 3 Decades of Landcover Changes in Piauí, Brazil
Authors: Lopes Danilo de Sousa , Nóbrega Rodrigo Affonso de Albuquerque , Macedo Diego Rodrigues
Published: June 2022

Mapping the changes of land use and cover through the classification of satellite images is one of the essential sources to investigate and monitor the Earth´s surface. When performed in a multitemporal perspective, this approach requires specific procedures to match the images used. Considering that parkland/grassland savanna patches could increase over time due to different uses, this research aims to present a suitable method for processing Landsat-like images to investigate land cover dynamics. The study area covers seven municipalities in the Brazilian state of Piauí, Cerrado biome, which has been substantially affected by deforestation due to extensive agricultural projects in the past decades. The semi-automatic satellite imaging georegistration and the object-oriented classification of Landsat 5 and 8 satellites over the last 30 years in decadal periods are among the methodological procedures used. Findings demonstrate the semi-automatic image registration process as an effective method for the geometric correction of Landsat scenes, and the object-based classification procedures are appropriate for multitemporal studies allowing comparative metrics of landcover class changes by period. Regarding the remaining natural landcover within the study area, the results showed a substantial decrease of woodland savanna patches from 73% in 1986 to 43% in 2016, while agricultural fields increased from 4% to 25% in 30 years.
A Incerteza no Mapeamento dos Limites Espaciais das Feições Geográficas
Authors: Silva Willian Alves da , Deus Leandro Andrei Beser de
Published: June 2022

Com a avanço das resoluções espaciais e temporais das imagens de satélite, ocorre aumento da demanda por produtos cartográficos com escala maiores. Para a cartografia, o aumento de resolução significa a possibilidade de se detectar os limites dos objetos que se quer mapear com maior precisão. Quando se observa um produto cartográfico vetorial, todas as feições representadas, são regiões que apresentam alguma característica que as diferenciam do “continuum” ao seu redor. Porém, várias das feições com as quais os cartógrafos trabalham no dia a dia, carecem de limites geométricos bem definidos, nítidos. Linhas litorâneas, Biomas em geral, Zonas de Risco, Frente Frias, Zonas de Criminalidade etc., são exemplos de feições que necessitam ser mapeadas, mas devido a suas características, apresentam desafios para serem modeladas geometricamente. Neste trabalho será apresentada uma revisão bibliográfica, apoiada por diversos exercício conceituais, com o objetivo de mostrar como a incerteza posicional dos limites das feições geográficas afeta o processo cartográfico (da coleta à representação), e como uma classificação destes limites e também dos tipos de incertezas associadas, pode ajudar no melhor entendimento e tratamento da informação geoespacial.
Métodos de Planejamento de Rotas para RPAs: uma Revisão da Literatura
Authors: Simões Débora Paula , Oliveira Henrique Candido de , Lima Júnior Orlando Fontes , Costa Diogenes Cortijo
Published: June 2022

Nos dias atuais, as aeronaves remotamente pilotadas (RPAs), popularmente conhecidas como drones, atuam em aplicações de diversas áreas, aumentando em número de aeronaves e compartilhando do espaço aéreo. Nesse cenário, a segurança é fator crucial e, portanto, planejar rotas confiáveis se torna essencial. Múltiplos são os algoritmos baseados em inteligência computacional, bem como as funções heurísticas, adotados para a roteirização de RPAs. No entanto, para bem aplicá-los, dependendo da finalidade do voo, é fundamental conhecer os diversos métodos de planejamento de rotas para RPAs. Diante disso, o presente estudo tem por objetivo apresentar, por meio de uma revisão de literatura, os diferentes métodos de roteirização de RPAs, enfatizando suas principais características e apresentando estudos que os envolvam. Trinta e nove artigos publicados entre 2002 e 2020, disponíveis em diferentes bases de dados, foram estudados, os quais possibilitaram classificar os métodos de planejamento em três grupos: baseados no domínio do tempo (online ou offline), em função do modelo de ambiente (2D ou 3D) e com relação às características da aeronave (asa fixa, rotativa, oscilante ou modelo híbrido). Ademais, destacam-se estudos envolvendo algoritmos e funções heurísticas aplicados a cada método de roteirização identificado. Com base nas referências revisadas, evidencia-se que as pesquisas tendem para a roteirização tridimensional e online, uma vez que abordam condições e ambientes mais realistas de voo, cujas características principais são enfatizadas ao final desse estudo.
School Nurses’ Perspectives of Bullying Involvement of Adolescents with Chronic Health Conditions
Authors: Cohen Sally , Grunin Laura , Guetterman Timothy
Published: June 2022

Objective: Our primary objective was to understand bullying as it pertains to middle school students with chronic physical or behavioral health conditions by examining it through the lens of school nurses. A second objective was to understand issues pertaining to implementation of New York’s bullying prevention law with a focus on these same students. Methods: We employed a qualitative descriptive design with purposive sampling to explore perspectives of school nurses in New York State who worked in public middle schools. Using a semi-structured protocol, we conducted audio-recorded telephone interviews that were transcribed for subsequent thematic analysis. Results: Twelve nurses agreed to be interviewed. Results revealed participants’ understanding of bullying as related to students with chronic health conditions, especially those with behavioral health issues. Results also showed nurses’ limited understanding of New York’s bullying prevention law and missed opportunities for school nurses as champions of students with chronic health conditions who are bullied. Conclusions: Education and health care professionals should collaborate to disseminate information to school personnel about the risks of bullying for students with chronic health conditions and operationalize plans for prevention.
Student Concerns Regarding School-based Weight Measurement: Implications for Policy
Authors: Igler Eva , Everhart Samantha , Austin Jillian , Lang Amy , Hobart Davies William
Published: June 2022

Objective: Many schools implement health screening programs that include weight measurement. The potential negative consequences and effectiveness of these programs in improving adolescent health remains unclear. The purpose of this study was to examine perceptions of weight measurement practices among emerging adults, some of whom (64%) had previously had their weight measured in a school setting. Methods: Altogether, 239 primarily white (75%) and female (66%) emerging adults provided their opinion regarding school weight measurement policies and experiences being weighed in middle and/or high school. Results: Overall, 37% of the total sample, regardless of personal experience, reported a negative reaction to school weight measurement policy, and 19% described course requirements for weight measurement as unhelpful. Of participants who reported being weighed in a school setting, 31% indicated a negative reaction, 57% rated the process as inappropriate, and 40% rated the process as uncomfortable. Conclusions: Many students may respond negatively to being weighed in the school setting. If schools implement a weight measurement policy, it is essential they mitigate risks and follow the American Academy of Pediatrics (AAP) criteria for general health screening programs in schools. We provide suggestions for implementing AAP criteria.
Endometriosis at all ages: diagnostic ultrasound
Authors: Bäumler Marcel , Heiss Niko , Druckmann Rene
Published: June 2022

Endometriosis is a gynecological disease affecting about 10% of the female population. The multifactorial hormonal, inflammatory, genetic, mental and behavior pathogenesis can result in chronic pelvic pain, blooding disorders and infertility causing disruption of quality of life. Correct diagnosis of the extension and topography is substantial in defining the adequate therapeutic strategy. In an increasing proportion of the cases, endometriosis is being managed medically and para-medically; diagnostic or therapeutic surgery can often be avoided or delayed. Transvaginal sonography is considered being the first-line imaging method in the diagnosis of pelvic endometriosis. The paradigm shift from the belief that endometriosis only affects women of reproductive age has drawn attention to endometriosis in both premenarchal and postmenopausal patients. This review resumes the actually recommended ultrasound signs in the case of patients in menstrual age. Specific diagnostic approaches in adolescent and menopausal patients are highlighted.
Punishment in Tort: The Context of Ideas in Rookes v. Barnard
Authors: Sinanis Nicholas
Published: June 2022

Modern corrective justice theorists of tort law remain critical of the Anglo-American common law doctrine that allows a plaintiff to be awarded damages beyond compensation, and for the distinct purpose of punishing a defendant in a civil tort action. From the corrective justice standpoint, punishment is an illegitimate remedial purpose of the law of tort. So much so, that the historical doctrine of civil damages that continues to allow for it – exemplary (or punitive) damages – should be totally abolished. This article revisits a historical tort case that modern corrective justice tort theorists have praised for very nearly abolishing the exemplary damages doctrine in one leading common law jurisdiction: it critically explores the 1964 decision of the Appellate Committee of the United Kingdom House of Lords in Rookes v. Barnard. In doing so, it strives to set this theoretically significant reform of the English law of civil tortious recovery more vividly in the historical context in which it was undertaken. It contends that a deeper appreciation of Rookes’ theoretical significance requires taking fuller account of the context of ideas in which Lord Devlin – the Law Lord to whom the House’s decision on damages is ascribed – undertook it.
“Tales from the Trail”: Oratory and Affect among Alaska Dog Mushers
Authors: Shoaps Robin A. , Plattet Patrick
Published: June 2022

This paper draws from linguistic anthropological and ethnographic fieldwork to illustrate the role of award ceremonies in maintaining and creating affective orientations toward rivalry among Alaska dog mushers. It focuses on award speeches given by dog mushers and others involved in the Alaska dog mushing community and reveals a “need for narrative” that has characterized sled dog racing since its origin as an (inter)national sport. Mushing “stories” are constitutive of public talk about wins and losses in the sport, as well as about race events that take place far from view on distant trails. Specifically, “accounts,” a humorous narrative genre that pivots upon unpredictable “instinct-driven” characteristics of canine athletes, serve as an important idiom for evoking chance in describing wins and losses. The performance and appreciation of these narratives constitute the intangible heritage of Alaska dog mushers, and accounts emerge as a semiotic resource for negotiating and downplaying rivalry through orchestration of embodied intersubjective sentiments, i.e. affect.
Tellurium-induced functional group activation
Authors: Ray Devalina , Das Aparna , Mazumdar Suman , Banik Bimal K.
Published: June 2022

Tellurium-chemistry comprises of vibrant and innovative prospects in major area of research and development. The function of Tellurium in organic synthesis remained underexplored till date. Moreover, the reactivity of Tellurium as Lewis acid or electrophilic reagents to activate functional group conceptually remains as an ever-demanding area to be investigated extensively. In this context, the present compilation portrays a detailed study on the reactivity of organotellurium compounds as catalyst, reagent, and sensors to explore the reactions occurring specifically through functional group activation.
Control of the single-order harmonic generation by changing the laser parameters of two-color pulse
Authors: Liu Hang , Feng Liqiang
Published: June 2022

We theoretically investigate the control of the single-order harmonic generation by changing the laser parameters of two-color pulse. Four important results have been found. For instance, (1) as the controlling chirp changes from the down-chirp to the up-chirp, the generation of the single-order harmonic can move to the lower harmonic order. (2) As the main pulse duration increases, the larger order single harmonic can be found. While, as the controlling pulse duration increases, the multi-orders harmonic enhancements can be found instead of the single-order harmonic enhancement. (3) As the main laser intensity increases, the larger order single harmonic can be obtained. While, as the controlling laser intensity increases, the multi-orders harmonic enhancements are obtained. (4) With the increase of the wavelength of the main pulse, the lower order single harmonic can be found. While, as the controlling laser wavelength increases, the single-order harmonic is disappeared. Finally, through analyzing the harmonic emission process, the reasonable explanation of the single-order harmonic control is given.
Effect of Taurine Supplement on Aerobic and Anaerobic Outcomes: Meta-Analysis of Randomized Controlled Trials
Authors: Buzdağlı Yusuf , Eyipınar Cemre Didem , Tekin Aslıhan , Şıktar Erdinç , Zydecka Karolina Skonieczna
Published: June 2022

Taurine is a well-known free amino acid that has gained prominence in recent years despite its little or no role in protein formation. Few studies on the ergogenic effect of taurine exist with inconsistent results. The answer to the question of whether performance markers demonstrate the benefit of taurine remains unclear. This study aimed to reach a consensus about whether taurine supplementation is effective on aerobic (time to exhaustion [TTE], maximal oxygen uptake [V̇o
2max], and rating of perceived exertion) and anaerobic (power outputs, fatigue index, jumping, and blood lactate level) performance outputs. Google Scholar, PubMed databases, clinical trial websites, and gray literature were reviewed until November 2021. Mean differences (MDs) were pooled using random or fixed-effects models according to the heterogeneity degree of the related output. Although 18 studies were detected for the meta-analysis between 2001 and 2021, 16 studies were grouped. Only randomized controlled trials (single or double-blind) were considered. Taurine supplementation had a significant effect on vertical (MD = 3.60; 95% confidence interval [CI] [2.32 to 4.89], p < 0.00001) and countermovement (MD = 8.50; 95% CI [4.78 to 12.22], p < 0.00001) jump performance when compared with a placebo group. Taurine supplementation had no significant effect on the V̇o
2max level and rate of perceived exertion (respectively, MD = −0.54 mL/kg/min; 95% CI [−6.84 to 5.75], p = 0.87; MD = −0.24; 95% CI [−0.74 to 0.27], p = 0.35) when compared with a placebo group. Overall, it looks to be effective for jumping performance and TTE. Taurine supplementation may be useful for people who want to improve these performance outputs.
Sistem Cerdas Penghitung Jumlah Mobil untuk Mengetahui Ketersediaan Lahan Parkir berbasis Python dan YOLO v4
Authors: Rizkatama Getsa Novandra , Nugroho Anan , Suni Alfa Faridh
Published: June 2022

Perkembangan teknologi pada era digital semakin cepat, mulai dari bidang hardware maupun software. Software atau perangkat lunak sering digunakan pada sebuah sistem, baik untuk otomatisasi sistem itu sendiri, maupun digunakan untuk membantu manusia dalam kehidupan sehari-hari. Pencarian sebuah lahan parkir yang tersedia menjadi sebuah permasalahan yang dihadapi oleh manusia pada saat hendak memasuki sebuah lahan parkir. Pembayaran biaya masuk lahan parkir menjadi kendala saat lahan parkir tidak ditemukan. Maka dari itu pengembangan sebuah sistem yang digunakan sebagai pendeteksi ketersediaan lahan parkir menjadi salah satu solusinya. Sistem atau perangkat lunak dikembangkan menggunakan bahasa pemrograman Python dan YOLO v4. Ketersediaan lahan parkir dihitung dengan membandingkan hasil deteksi mobil dengan ketersediaan lahan parkir. Deteksi dilakukan dengan menggunakan algoritma YOLO v4 dengan dataset COCO yang ditandai dengan bounding box dan confidence level. Berdasarkan hasil pengujian pada beberapa video, didapatkan tingkat akurasi program sebesar 72,8%.
Pengembangan Media dan Bahan Ajar Interaktif â€œScan Itâ€ Berbasis Geogebra
Authors: Apriliani Laely Rohmatin , Irham Muhammad , Darojat Latifah
Published: June 2022

Penelitian ini bertujuan untuk mendeskripsikan proses pengembangan media dan bahan ajar interaktif â€œScan Itâ€ berbasis Geogebra. Penelitian ini merupakan penelitian pengembangan. Model pengembangan yang digunakan adalah model pengembangan ADDIE. Subjek penelitian ini adalah peserta didik kelas XI SMK. Penelitian ini menggunakan tiga kelas Â yaitu untuk uji coba, eksperimen, dan kontrol. Desain penelitian ini adalah Desain penelitian Nonrandomized Control Group, Pretest-Postest Desain. Hasil dari penelitian ini adalah media dan bahan ajar interaktif â€œScan Itâ€ berbasis geogebra valid, praktis, dan efektif. Peserta didik yang menunjukkan respon positif adalah sebanyak 96%. Sebanyak 58,3% peserta didik mengalami peningkatan kemampuan keruangan sedang dan 33,3% peserta didik mengalami peningkatan kemampuan keruangan tinggi.The research aims was to describe the process of developing media and interactive teaching materials "Scan It" based on Geogebra. This research was a development research. The development model used is the ADDIE development model. The subjects of this study were students of class XI SMK. This study used three classes, namely for trials, experiments, and controls. The research design was a nonrandomized control group research design, pretest-posttest design. The results of this research were media and interactive teaching materials "Scan It" based on geogebra, which were valid, practical, and effective. Students who showed a positive response were 96%. As many as 58.3% of students experienced an increase in moderate spatial abilities and 33.3% of students experienced an increase in high spatial abilities.
[Editorial Review] Ethnomathematics in Educational Research Circles
Authors: Prabowo Ardhi , Amidi Amidi , Munahefi Detalia Noriza
Published: June 2022

The development of ethnomathematical research is currently experiencing a fairly rapid increase in interest. This can be seen in the many ethnomathematical researches in the inaugural issue of Kreano, a creative-innovative mathematics journal, in English.Perkembangan riset etnomatematika saat ini mengalami peningkatan minat yang cukup pesat. Hal ini dapat dilihat pada banyaknya riset etnomatematika pada terbitan perdana Kreano, jurnal matematika kreatif-inovatif, dalam Bahasa inggris.