bluuebunny/crossref_metadata_2025 huggingface dataset:
Oil/water separation and functionality of smart carbon nanotube–titania nanotube composite
Authors: Morsy Mohamed , Abdel-Salam Ahmed I. , Rayan Diaa A. , Gomaa Islam , Elzwawy Amir
Published: November 2022

Water treatment applications are in high demand recently. In this work, the titania nanotube (TNT) was successfully grown onto the outer surface of the carbon nanotubes (CNTs) via the hydrothermal method. The resultant prepared composite was doped with different ratios of nitrogen. The structural and morphological merits of the composites displayed the successful composition of the matrices, as well as the particle size of the composite within the nanoscale. The optical specifications of the composites demonstrate successful direct and indirect transitions with a high energy gap (> 3 eV). The testing of different oils in the water/oil separation exhibited a high rate of success to split oil and water (> 95%). In this regard, CNT-TNT 1.0 sample reflects the highest efficiency. Compared to other researchers that demonstrate the highest efficiency of their proposed structure, our membrane offers a decent separation efficiency. The proposed composite might provide a feasible and cost-effective method for water/oil separation application in the nanotechnological fields.

Graphical abstract
The Effect of Thermal Misbalance on Slow Magnetoacoustic Waves in a Partially Ionized Prominence-Like Plasma
Authors: Ibañez M. H. , Ballester J. L.
Published: November 2022

Solar prominences are partially ionized plasma structures embedded in the solar corona. Ground- and space-based observations have confirmed the presence of oscillatory motions in prominences, which have been interpreted in terms of standing or propagating MHD waves. Some of these observations suggest that slow magnetoacoustic waves could be responsible for these oscillations and have provided us with evidence about their damping/amplification with very small ratios between damping/amplifying times and periods, which have been difficult to explain from a theoretical point of view. Here we investigate the temporal behavior of non-adiabatic, slow, magnetoacoustic waves when a heating–cooling misbalance is present. The influence of optically thin losses and of a general heating term, in which density and temperature dependence can be modified, as well as the effect of partial ionization have been considered. Furthermore, a tentative example of how, using observational data, the observed ratio between damping/amplifying times and periods could be matched with those theoretically obtained is shown. In summary, different combinations of radiative losses, heating mechanisms, and typical wavenumbers, together with the effect of partial ionization, could provide a theoretical tool able to reproduce observational results on small-amplitude oscillations in prominences.
The detection of African trypanosomes in goats reared in tsetse infested villages of Eastern Zambia
Authors: Mulenga Gloria M. , Gummow Bruce
Published: November 2022

Control programmes for African animal trypanosomiasis (AAT) in livestock have been mainly focused on cattle with very little focus on goats, an important reservoir for the disease. Using the polymerase chain reaction (PCR), this study investigated trypanosome infection in village goats in Mambwe, a rural District in Eastern Zambia. Filter paper blood spots were collected from 326 goats and tested for infection with Trypanosoma congolense, Trypanosoma vivax and Trypanosoma brucei s.l. using ribosomal RNA internal transcribed spacers (ITS)-PCR. The frequency of trypanosomes from the sampled goats was 4.6% (95% CI = 2.3–6.8). Results indicated significantly high infections with Trypanosoma vivax (4.0%; 95% CI = 1.9–6.1) than T. congolense (0.6%; 95% CI =  − 0.2 to 1.5), and T. brucei (0.0%), P = 0.04. Findings show the circulation of trypanosomes that causes AAT in goats and that they may pose serious threats to not only goats but also to other livestock reared alongside goats.
Co-infection patterns of vector-borne zoonotic pathogens in owned free-ranging dogs in central Chile
Authors: Cevidanes Aitor , Di Cataldo Sophia , Muñoz-San Martín Catalina , Latrofa Maria Stefania , Hernández Claudia , Cattan Pedro E. , Otranto Domenico , Millán Javier
Published: November 2022

We investigated the co-occurrence of the nine of the most relevant canine vector-borne pathogens (CVBP) using conventional and real-time PCR and evaluated risk factors and potential non-apparent haematological alterations associated with co-infection in 111 rural, owned, free-ranging dogs in the Metropolitan Region of Chile.

At least one pathogen was detected in 75% of the dogs. DNA of Anaplasma platys (Ap; 36%), Candidatus Mycoplasma haematoparvum (CMhp; 31%), Mycoplasma haemocanis (Mhc; 28%), Trypanosoma cruzi (17%), Leishmania spp. (4.5%), and Acanthocheilonema reconditum (1%) was detected. All dogs were negative for Ehrlichia spp., Rickettsia spp., Bartonella spp., Piroplasmida, and Hepatozoon spp. Thirty-eight dogs (34%) were coinfected. CMhp was involved in 71%, Mhc in 58%, and Ap in 50% of the co-infections. The most common co-infection pattern was CMhp–Mhc (37% of the cases). The prevalence of Ap was higher in juvenile than in adult dogs, whereas the opposite was found for CMhp and Mhc. Adult dogs were four times more likely of being co-infected than juveniles. Co-infected animals showed higher white blood cell count, segmented neutrophil count, and GGT levels than non-co-infected dogs. Clinically healthy but infected dogs may act as reservoirs of CVBP, and their free-ranging behavior would facilitate the spread of these pathogens to other dogs as well as human beings or wild carnivores.
Acellular bovine pericardium as a biological dressing for treatment of cutaneous wounds of the distal limb in donkeys (Equus Asinus)
Authors: Albahrawy Mohammed , Abouelnasr Khaled , Mosbah Esam , Zaghloul Adel , Abass Marwa
Published: November 2022

This research was performed to determine the impact of repeated topical dressing with acellular bovine pericardium (ABP) on healing distal limb wounds in donkeys. Twelve male clinically healthy donkeys were subjected to general anesthesia, and full-thickness wounds of six cm2 (2 × 3 cm) were created on the middle dorsolateral surface of the metacarpi. Two defects were made on each donkey’s forelimbs; the right limb was considered a control wound, and the left one was considered a treated wound. Moreover, the control wounds were irrigated with saline every three days postoperatively and bandaged with a standard dressing. The treated wounds were covered with ABP dressings. The ABP dressing was reapplied thrice at 7-, 14- and 21-days post-wound induction. In addition, the wound healing process was monitored clinically, histopathologically, and immunohistochemically of tissue as growth factor-β1, epidermal growth factor receptor, and vascular endothelial growth factor. Besides, the gene expression profile of angiogenic and myofibroblastic genes was applied as vascular endothelial growth factor-A, collagen type 3α1, fibroblast growth factor 7, and the transforming growth factor-β1.

The results revealed that the wounds treated with ABP healed more quickly than the control wounds. Additionally, the mean days required for healing were significantly shorter in the ABP-treated wounds (p < 0.05; 69.5 ± 1.6) compared to control wounds (86.3 ± 3). Furthermore, immunohistochemical and gene expression analyses were significantly improved in ABP wounds than in control wounds. In conclusion, ABP is considered a natural biomaterial and promotes the healing of distal limb wounds in donkeys if applied weekly during the first three-week post-wound induction.
Repeatability of a piezoelectric force platform to measure impact metrics for a single model of football
Authors: Mills Katie L. , Billingham Johsan , Choppin Simon , Dunn Marcus , Senior Terry , Goodwill Simon
Published: November 2022

The visco-elastic properties of a football influence how it bounces and therefore its performance in a game. Previously, high-speed camera footage has been used to quantify deformation, coefficient of restitution and contact time for an impact between a football and a rigid surface but these systems do not provide any information on the forces acting on the football during the impact. The aim of this study was to determine the repeatability of measuring the peak impact force, impulse, rise time and loading rate for four samples of the same model of football using a commercial force platform (Kistler 9281EA). A football impacted the floor-mounted piezoelectric-type force platform at 6.04 and 19.4 m s−1. High absolute (coefficient of variation (CV) ≤ 10%) and relative (intraclass correlation coefficient (ICC) ≥ 0.94) repeatability was observed for repeated impacts at both velocities. The minimal detectable differences were calculated to evaluate the ability for the force platform to be used to make meaningful comparisons between footballs. For all metrics, the minimum detectable difference accounted for less than 5% of the mean value. Therefore, it can be concluded that provided the difference in impact metrics between football models exceeds the minimal detectable difference, the commercial force platform can be used to measure and detect differences in physical impact metrics between models of footballs.
Public wellbeing analytics framework using social media chatter data
Authors: Ismail Heba , Serhani M. Adel , Hussien Nada , Elabyad Rawan , Navaz Alramzana
Published: November 2022

Public wellbeing has always been crucial. Many governments around the globe prioritize the impact of their decisions on public wellbeing. In this paper, we propose an end-to-end public wellbeing analytics framework designed to predict the public’s wellbeing status and infer insights through the continuous analysis of social media content over several temporal events and across several locations. The proposed framework implements a novel distant supervision approach designed specifically to generate wellbeing-labeled datasets. In addition, it implements a wellbeing prediction model trained on contextualized sentence embeddings using BERT. Wellbeing predictions are visualized using several spatiotemporal analytics that can support decision-makers in gauging the impact of several government decisions and temporal events on the public, aiding in improving the decision-making process. Empirical experiments evaluate the effectiveness of the proposed distant supervision approach, the prediction model, and the utility of the produced analytics in gauging the public wellbeing status in a specific context.
Gruesome Looking Objects
Authors: Gaddis Elijah
Published: November 2022

The 1898 lynching of Tom Johnson and Joe Kizer is retold in this groundbreaking book. Unlike other histories of lynching that rely on conventional historical records, this study focuses on the objects associated with the lynching, including newspaper articles, fragments of the victims' clothing, photographs, and souvenirs such as sticks from the hanging tree. This material culture approach uncovers how people tried to integrate the meaning of the lynching into their everyday lives through objects. These seemingly ordinary items are repositories for the comprehension, interpretation, and commemoration of racial violence and white supremacy. Elijah Gaddis showcases an approach to objects as materials of history and memory, insisting that we live in a world suffused with the material traces of racial violence, past and present.
The Conduct of Hostilities under the Law of International Armed Conflict
Authors: Dinstein Yoram
Published: November 2022

The book serves as a companion to three other volumes published by Cambridge University Press, dealing respectively with the jus ad bellum, the law of belligerent occupation, and non-international armed conflicts. It is devoted to the core of the jus in bello - that is, the conduct of hostilities on land, at sea and in the air in inter-State armed conflicts - analyzed against the background of customary international law and treaties in force. The book deals with both means and methods of modern warfare. It addresses issues of general non-combatant protection, the principle of proportionality in collateral damage to civilians, and special protection, especially of the environment and cultural property. It also considers the relevant dimensions of international criminal law and deals with controversial matters such as unlawful combatancy, direct participation of civilians in hostilities and the use of 'human shields'. Case law and legal literature are cited throughout.
Modelling Turbulence in Engineering and the Environment
Authors: Hanjalić Kemal , Launder Brian
Published: November 2022

Modelling transport and mixing by turbulence in complex flows are huge challenges for computational fluid dynamics (CFD). This highly readable book introduces readers to modelling levels that respect the physical complexity of turbulent flows. It examines the hierarchy of Reynolds-averaged Navier-Stokes (RANS) closures in various situations ranging from fundamental flows to three-dimensional industrial and environmental applications. The general second-moment closure is simplified to linear eddy-viscosity models, demonstrating how to assess the applicability of simpler schemes and the conditions under which they give satisfactory predictions. The principal changes for the second edition reflect the impact of computing power: a new chapter devoted to unsteady RANS and another on how large-eddy simulation, LES, and RANS strategies can be effectively combined for particular applications. This book will remain the standard for those in industry and academia seeking expert guidance on the modelling options available, and for graduate students in physics, applied mathematics and engineering entering the world of turbulent flow CFD.
Prospect Utilitarianism and the Original Position
Authors: CHUNG HUN
Published: November 2022

Suppose we assume that the parties in the original position took Kahneman and Tversky's prospect theory as constituting their general knowledge of human psychology that survives through the veil of ignorance. How would this change the choice situation of the original position? In this paper, I present what I call ‘prospect utilitarianism’. Prospect utilitarianism combines the utilitarian social welfare function with individual utility functions characterized by Kahneman and Tversky's prospect theory. I will argue that, once prospect utilitarianism is on the table, Rawls's original arguments in support of justice as fairness as well as his arguments against utilitarianism are, at best, inconclusive. This shows that how implausible a choice for utilitarianism in the original position is heavily depends on what one assumes to be general knowledge of human psychology that the original contracting parties know.
A tractable mathematical model for rectified diffusion
Authors: Smith Warren R. , Wang Qianxi
Published: November 2022

A core unresolved challenge in rectified diffusion is the lack of predictive models, which allow accurate modelling of the growth of bubbles over millions of cycles of oscillation. The spherically symmetric problem involves two asymptotic regions in space for the convection and diffusion of the dissolved gas in the liquid, an inner region adjacent to the bubble and an outer region. It also involves three time scales: the shortest time scale associated with the bubble oscillation, the intermediate and the longest time scales for the mass transport across the bubble interface and the outer region, respectively. The problem is analysed systematically using matched asymptotic expansions in space and multi-scales in time, the large parameter being the Péclet number for mass transfer. A tractable mathematical model is formulated for rectified diffusion. It comprises the Rayleigh–Plesset equation for the spherical oscillations of the bubble on the shortest time scale, an ordinary differential equation for the mass of gas in the bubble on the intermediate time scale and a diffusion equation on the longest time scale and the long length scale. Predictions of this simplified model have excellent agreement with experimental results for a single spherical bubble in the bulk over millions of cycles of oscillation. A parametric study is undertaken with several new phenomena/features observed for acoustic frequencies in the range 12 to 62 kHz, acoustic field

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of the saturation concentration.
Configuration design and dimensional synthesis of an asymmetry 2R1T parallel mechanism
Authors: Peng Siyang , Cheng Zhihong , Che Linxian , Cui Song , Jin Zujin
Published: November 2022

This paper focuses on configuration design, dimensional synthesis, and engineering application of a novel asymmetric 2R1T parallel mechanism (PM) with zero-coupling degree. The analytical forward and inverse displacement solutions are deduced by the means of vector method. The mathematical models between Euler angles and the orientational parameters (i.e., azimuth and tilt angles) of the offset output axis are established. Using screw theory as mathematical tool, this paper worked out evaluation indices of motion/force transmissibility and presented the definitions and calculation methods of good transmission orientation workspace and good transmission orientation capacity (GTOC). Furthermore, a comparative example with respect to kinematic performance of asymmetric UPS-RPU-PU PM and planar symmetric 2UPS-PU PM is carried out, and the result demonstrates that UPS-RPU-PU significantly outperforms 2UPS-PU in terms of GTOC. The constrained optimization model is constructed to formulate optimal problem of dimensional parameters on the maximizing GTOC, which is then solved by differential evolution algorithm. Finally, an engineering case demonstrates that the optimized mechanism has a good application prospect in hydraulic support test bed.
The Seismicity of Mars Observed by the NASA InSight Mission
Authors: Giardini D. , Ceylan S. , Clinton J. , Lognonné PH. , Stähler S.
Published: November 2022

This Plenary Lecture summarizes the seismicity of Mars recorded by the NASA InSight mission, which landed on Elysium Planitia on 26 August 2018. Equipped with a highly sensitive seismometer, the lander has been successfully recording the seismicity of Mars for over three years. Different types of marsquakes have been identified, including low-frequency events with mantle-going phases and shallow high-frequency events characterized by crustal propagation. More recently, a few meteoric impacts have also been identified. Over a thousand events have been recorded, with magnitudes reaching up to MW 4.7. Here we review the techniques used by the MarsQuake Service to locate and characterize marsquakes and the active crustal processes in different areas of the red planet, and we discuss the different types of marsquakes.
3D Coseismic Surface Displacements From Historical Aerial Photographs of the 1987 Edgecumbe Earthquake, New Zealand
Authors: Delano J. E. , Howell A. , Stahl T. A. , Clark K.
Published: November 2022

Earthquake surface deformation provides key constraints on the geometry, kinematics, and displacements of fault rupture. However, deriving these characteristics from past earthquakes is complicated by insufficient knowledge of the pre‐event landscape and its post‐event modification. The 1987 Mw 6.5 Edgecumbe earthquake in the northern Taupō volcanic zone (TVZ) in New Zealand represents a moderate‐magnitude earthquake with distributed surface rupture that occurred before widespread high‐resolution topographic data were available. We use historical aerial photos to build pre‐ and post‐earthquake digital surface models (DSMs) using structure‐from‐motion techniques. We measured discrete and distributed deformation from differenced DSMs and compared the effectiveness of the technique to traditional field‐ and lidar‐based studies. We identified most fault traces recognized by 1987 field mapping, mapped newly identified traces, and made dense remote slip measurements with a vertical separation resolution of ∼0.3 m. Our maximum and average vertical separation measurements on the Edgecumbe fault trace (2.5 ± 0.3 and 1.2 m, respectively), are similar to field‐based values of 2.4 and 1.1 m, respectively. Importantly, this technique can discern between new and pre‐existing fault scarps better than field techniques or post‐earthquake lidar‐based measurements alone. Our surface displacement results are used to refine subsurface fault geometries and slip distributions at depth, which are further used to investigate potential magmatic‐tectonic stress interactions in the northern TVZ. Our results suggest the Edgecumbe fault dips more gently at depth than at the surface, hosted shallow slip in 1987, and may be advanced toward failure by interactions with nearby magma bodies.
Structural disconnection-based prediction of poststroke depression
Authors: Pan Chensheng , Li Guo , Jing Ping , Chen Guohua , Sun Wenzhe , Miao Jinfeng , Wang Yanyan , Lan Yan , Qiu Xiuli , Zhao Xin , Mei Junhua , Huang Shanshan , Lian Lifei , Wang He , Zhu Zhou , Zhu Suiqiang
Published: November 2022

Poststroke depression (PSD) is a common complication of stroke. Brain network disruptions caused by stroke are potential biological determinants of PSD but their conclusive roles are unavailable. Our study aimed to identify the strategic structural disconnection (SDC) pattern for PSD at three months poststroke and assess the predictive value of SDC information. Our prospective cohort of 697 first-ever acute ischemic stroke patients were recruited from three hospitals in central China. Sociodemographic, clinical, psychological and neuroimaging data were collected at baseline and depression status was assessed at three months poststroke. Voxel-based disconnection-symptom mapping found that SDCs involving bilateral temporal white matter and posterior corpus callosum, as well as white matter next to bilateral prefrontal cortex and posterior parietal cortex, were associated with PSD. This PSD-specific SDC pattern was used to derive SDC scores for all participants. SDC score was an independent predictor of PSD after adjusting for all imaging and clinical-sociodemographic-psychological covariates (odds ratio, 1.25; 95% confidence interval, 1.07, 1.48; P = 0.006). Split-half replication showed the stability and generalizability of above results. When added to the clinical-sociodemographic-psychological prediction model, SDC score significantly improved the model performance and ranked the highest in terms of predictor importance. In conclusion, a strategic SDC pattern involving multiple lobes bilaterally is identified for PSD at 3 months poststroke. The SDC score is an independent predictor of PSD and may improve the predictive performance of the clinical-sociodemographic-psychological prediction model, providing new evidence for the brain-behavior mechanism and biopsychosocial theory of PSD.
Updated cost-effectiveness analysis of lung cancer screening for Australia, capturing differences in the health economic impact of NELSON and NLST outcomes
Authors: Behar Harpaz Silvia , Weber Marianne F. , Wade Stephen , Ngo Preston J. , Vaneckova Pavla , Sarich Peter E. A. , Cressman Sonya , Tammemagi Martin C. , Fong Kwun , Marshall Henry , McWilliams Annette , Zalcberg John R. , Caruana Michael , Canfell Karen
Published: November 2022

Background

A national, lung cancer screening programme is under consideration in Australia, and we assessed cost-effectiveness using updated data and assumptions.

Methods

We estimated the cost-effectiveness of lung screening by applying screening parameters and outcomes from either the National Lung Screening Trial (NLST) or the NEderlands–Leuvens Longkanker Screenings ONderzoek (NELSON) to Australian data on lung cancer risk, mortality, health-system costs, and smoking trends using a deterministic, multi-cohort model. Incremental cost-effectiveness ratios (ICERs) were calculated for a lifetime horizon.

Results

The ICER for lung screening compared to usual care in the NELSON-based scenario was AU$39,250 (95% CI $18,150–108,300) per quality-adjusted life year (QALY); lower than the NLST-based estimate (ICER = $76,300, 95% CI $41,750–236,500). In probabilistic sensitivity analyses, lung screening was cost-effective in 15%/60% of NELSON-like simulations, assuming a willingness-to-pay threshold of $30,000/$50,000 per QALY, respectively, compared to 0.5%/6.7% for the NLST. ICERs were most sensitive to assumptions regarding the screening-related lung cancer mortality benefit and duration of benefit over time. The cost of screening had a larger impact on ICERs than the cost of treatment, even after quadrupling the 2006–2016 healthcare costs of stage IV lung cancer.

Discussion

Lung screening could be cost-effective in Australia, contingent on translating trial-like lung cancer mortality benefits to the clinic.
Low levels of sibship encourage use of larvae in western Atlantic bluefin tuna abundance estimation by close-kin mark-recapture
Authors: McDowell Jan R. , Bravington Mark , Grewe Peter M. , Lauretta Matthew , Walter John F. , Baylis Shane M. , Gosselin Thierry , Malca Estrella , Gerard Trika , Shiroza Akihiro , Lamkin John T. , Biesack Ellen E. , Zapfe Glenn , Ingram Walter , Davies Campbell , Porch Clay
Published: November 2022

Globally, tunas are among the most valuable fish stocks, but are also inherently difficult to monitor and assess. Samples of larvae of Western Atlantic bluefin tuna Thunnus thynnus (Linnaeus, 1758) from standardized annual surveys in the northern Gulf of Mexico provide a potential source of “offspring” for close-kin mark-recapture (CKMR) estimates of abundance. However, the spatial patchiness and highly skewed numbers of larvae per tow suggest sampled larvae may come from a small number of parents, compromising the precision of CKMR. We used high throughput genomic profiling to study sibship within and among larval tows from the 2016 standardized Gulf-wide survey compared to targeted sampling carried out in 2017. Full- and half-siblings were found within both years, with 12% of 156 samples in 2016 and 56% of 317 samples in 2017 having at least one sibling. There were also two pairs of cross cohort half-siblings. Targeted sampling increased the number of larvae collected per sampling event but resulted in a higher proportion of siblings. The combined effective sample size across both years was about 75% of the nominal size, indicating that Gulf of Mexico larval collections could be a suitable source of juveniles for CKMR in Western Atlantic bluefin tuna.
Hyperglycemia and cancer in human lung carcinoma by means of Raman spectroscopy and imaging
Authors: Kopeć M. , Beton K. , Jarczewska K. , Abramczyk H.
Published: November 2022

Raman spectroscopy and Raman imaging were used to identify the biochemical and structural features of human cancer lung cells (CCL-185) and the cancer cells supplemented with glucose and deuterated glucose at normal and hyperglycemia conditions. We found that isotope substitution of glucose by deuterated glucose allows to separate de novo lipid synthesis from exogenous uptake of lipids obtained from the diet. We demonstrated that glucose is largely utilized for de novo lipid synthesis. Our results provide a direct evidence that high level of glucose decreases the metabolism via oxidative phosphorylation in mitochondria in cancer cells and shifts the metabolism to glycolysis via Warburg effect. It suggests that hyperglycemia is a factor that may contribute to a more malignant phenotype of cancer cells by inhibition of oxidative phosphorylation and apoptosis.
The inverted U-shaped relationship between knowledge diversity of researchers and societal impact
Authors: Wang Gaofeng , Gan Yetong , Yang Haodong
Published: November 2022

With the increasing importance of interdisciplinary research, some studies have focused on the role of reference diversity by analysing reference lists of published papers. However, the relationship between the knowledge diversity of collaborating team members and research performance has been overlooked. In this study, we measured knowledge diversity through the disciplinary attributes of collaborating authors and research performance (understood as societal impact) through altmetric data. The major findings are: (1) The relationship between interdisciplinary collaboration diversity and societal impact is not a simple linear one, showing an inverted U-shaped pattern; and (2) As the number of collaborative disciplines increases, the marginal effects diminish or even become outweighed by the costs, showing a predominance of negative influences. Hence, diversity in interdisciplinary collaboration does not always have a positive impact. Research collaborations need to take into account the cost issues associated with the diversity of member disciplines.
Excess all-cause mortality in the USA and Europe during the COVID-19 pandemic, 2020 and 2021
Authors: Rossen Lauren M. , Nørgaard Sarah K. , Sutton Paul D. , Krause Tyra G. , Ahmad Farida B. , Vestergaard Lasse S. , Mølbak Kåre , Anderson Robert N. , Nielsen Jens
Published: November 2022

Both the USA and Europe experienced substantial excess mortality in 2020 and 2021 related to the COVID-19 pandemic. Methods used to estimate excess mortality vary, making comparisons difficult. This retrospective observational study included data on deaths from all causes occurring in the USA and 25 European countries or subnational areas participating in the network for European monitoring of excess mortality for public health action (EuroMOMO). We applied the EuroMOMO algorithm to estimate excess all-cause mortality in the USA and Europe during the first two years of the COVID-19 pandemic, 2020–2021, and compared excess mortality by age group and time periods reflecting three primary waves. During 2020–2021, the USA experienced 154.5 (95% Uncertainty Interval [UI]: 154.2–154.9) cumulative age-standardized excess all-cause deaths per 100,000 person years, compared with 110.4 (95% UI: 109.9–111.0) for the European countries. Excess all-cause mortality in the USA was higher than in Europe for nearly all age groups, with an additional 44.1 excess deaths per 100,000 person years overall from 2020–2021. If the USA had experienced an excess mortality rate similar to Europe, there would have been approximately 391 thousand (36%) fewer excess deaths in the USA.
Optic radiation atrophy in Lewy body disease with visual hallucination on phase difference enhanced magnetic resonance images
Authors: Miyata Mari , Kakeda Shingo , Yoneda Tetsuya , Ide Satoru , Okada Kazumasa , Adachi Hiroaki , Korogi Yukunori
Published: November 2022

Visual hallucinations (VH) occur commonly in Lewy body disease (LBD), including Parkinson’s disease (PD), PD with dementia, and dementia with Lewy bodies. We aimed to use phase difference enhanced imaging (PADRE) to assess structural abnormalities of optic radiation (OR) in patients with Lewy body disease (LBD) concomitant with VH. Firstly, two radiologists reviewed the OR appearances in healthy subjects (HS) on PADRE. Next, based on the OR abnormalities, two reviewers assessed the PADRE images from 18 HS and 38 and 110 patients with LBD, with and without VH, respectively, in a blinded manner. Finally, all patients with LBD without VH were eventually followed up for at least 5 years after magnetic resonance imaging to determine the appearance of VH. The radiologists identified three layers, namely external sagittal stratum, internal sagittal stratum, and tapetum, in OR on the PADRE in HS. Moreover, they were able to consensually define the OR as abnormal when the layers were obscured and the disappearance of the cranial side. The sensitivity/specificity of abnormal OR for each case was 68%/81% (LBD with VH vs. LBD without VH). Furthermore, VH appeared in 12 of the 21 (57%) patients with LBD and abnormal OR during the follow-up period. However, no patients without abnormal OR reported VH. Patients with LBD and VH demonstrated the abnormal OR. This, in turn, might be a useful marker to distinguish the patients with VH from those without VH and HS. Moreover, abnormal OR on PADRE may precede the appearance of VH in LBD.
Expansion of fibroblast cell sheets using a modified MEEK micrografting technique for wound healing applications
Authors: Benchaprathanphorn Kanokaon , Sakulaue Phongphot , Siriwatwechakul Wanwipa , Muangman Pornprom , Chinaroonchai Kusuma , Namviriyachote Nantaporn , Viravaidya-Pasuwat Kwanchanok
Published: November 2022

Cell sheet engineering, a scaffold-free approach to fabricate functional tissue constructs from several cell monolayers, has shown promise in tissue regeneration and wound healing. Unfortunately, these cell sheets are often too small to provide sufficient wound area coverage. In this study, we describe a process to enlarge cell sheets using MEEK micrografting, a technique extensively used to expand skin autografts for large burn treatments. Human dermal fibroblast cell sheets were placed on MEEK’s prefolded gauze without any use of adhesive, cut along the premarked lines and stretched out at various expansion ratios (1:3, 1:6 and 1:9), resulting in regular distribution of many square islands of fibroblasts at a much larger surface area. The cellular processes essential for wound healing, including reattachment, proliferation, and migration, of the fibroblasts on expanded MEEK gauze were superior to those on nylon dressing which served as a control. The optimal expansion ratio with the highest migration rate was 1:6, possibly due to the activation of chemical signals caused by mechanical stretching and an effective intercellular communication distance. Therefore, the combination of cell sheet engineering with the MEEK micrografting technique could provide high quality cells with a large coverage area, which would be particularly beneficial in wound care applications.
Experimental evaluation of the effect of positioning and operating parameters on the performance of a surface-piercing propeller
Authors: Kamran Maryam , Nouri Norouz Mohammad , Goudarzi Hossein , Golrokhifar Saeed
Published: November 2022

Today, surface-piercing propellers have been recognized as a suitable choice for higher speeds. Yet, the development of design algorithms for such has been challenged by insufficient knowledge about the parameters affecting their performance. For this reason, developing experimental data and studying the influence of various parameters on their performance is crucial. Aiming to develop experimental knowledge of these propellers, this study investigates the impact of position parameters and Froude Number on model test results of a custom-designed propeller. Moreover, ventilation wake development at different Froude numbers was studied. The experimental results pointed to the favorable impact of increased immersion ratio on propeller's thrust, a positive impact of increasing the inclination angle by 6° on higher thrust and efficiency in the advance direction, and a slight increase of thrust with higher yaw angles up to 10°. The propeller's lateral forces were also extracted in different positions and operational conditions to identify the propeller's behavior and design the required shaft and supports. Finally, regression equations for projecting hydrodynamic coefficients used at the design phase were compared and verified by the experimental results. The results pointed to the insufficient precision of this model for estimating the hydrodynamic coefficients affecting the propeller.
Inflammation mediates approximately one quarter of excess relative all-cause mortality in persons with rheumatoid arthritis: the Trøndelag Health Study
Authors: Videm Vibeke , Houge Ingrid Sæther , Liff Marthe Halsan , Hoff Mari
Published: November 2022

Inflammation may contribute to excess mortality in rheumatoid arthritis (RA) patients. We investigated associations to all-cause mortality of the inflammation markers high-sensitivity C-reactive protein (CRP), lactoferrin (neutrophil activation marker), and neopterin (monocyte activation marker). From the population-based Trøndelag Health Study (3rd wave 2006–2008), 316 RA patients and 43,579 controls were included. Lactoferrin and neopterin were quantified in a nested cohort (n = 283 RA patients, n = 3698 controls). Follow-up was until death found by linkage to the Norwegian Cause of Death Registry or 31.12.2018. All-cause mortality was analyzed using Cox regression and Cox regression-based mediation analysis. Having RA (hazard ratio (HR): 1.25, 95%CI: 1.00, 1.56, p = 0.048), and CRP ≥ 3 mg/L (HR: 1.50, 95%CI: 1.41, 1.60, p < 0.001) were associated with all-cause mortality. The overall excess relative mortality risk of having RA was 38%. CRP ≥ 3 mg/L mediated approximately 1/4 of this risk (p < 0.001). In the nested cohort, CRP ≥ 3 mg/L (HR: 1.51, 95%CI: 1.26, 1.80, p < 0.001) and neopterin (HR: 1.17, 95%CI: 1.01, 1.36, p = 0.031) were associated with all-cause mortality. In conclusion, CRP levels ≥ 3 mg/L mediated approximately a quarter of the 38% excess relative all-cause mortality risk associated with RA. Using definitions of RA remission with emphasis both on joint status and the level of general inflammation may help guide the most efficient treatment regimens.
A computational account of how individuals resolve the dilemma of dirty money
Authors: Siegel Jenifer Z. , van der Plas Elisa , Heise Felix , Clithero John A. , Crockett M. J.
Published: November 2022

Money can be tainted when it is associated with direct or indirect harm to others. Deciding whether to accept “dirty money” poses a dilemma because money can be used to help others, but accepting dirty money has moral costs. How people resolve the dilemma of dirty money remains unknown. One theory casts the dilemma as a valuation conflict that can be resolved by integrating the costs and benefits of accepting dirty money. Here, we use behavioral experiments and computational modeling to test the valuation conflict account and unveil the cognitive computations employed when deciding whether to accept or reject morally tainted cash. In Study 1, British participants decided whether to accept “dirty” money obtained by inflicting electric shocks on another person (versus “clean” money obtained by shocking oneself). Computational models showed that the source of the money (dirty versus clean) impacted decisions by shifting the relative valuation of the money’s positive and negative attributes, rather than imposing a uniform bias on decision-making. Studies 2 and 3 replicate this finding and show that participants were more willing to accept dirty money when the money was directed towards a good cause, and observers judged such decisions to be more praiseworthy than accepting dirty money for one’s own profit. Our findings suggest that dirty money can be psychologically “laundered” through charitable activities and have implications for understanding and preventing the social norms that can justify corrupt behavior.
Zebras of all stripes repel biting flies at close range
Authors: Tombak Kaia J. , Gersick Andrew S. , Reisinger Lily V. , Larison Brenda , Rubenstein Daniel I.
Published: November 2022

The best-supported hypothesis for why zebras have stripes is that stripes repel biting flies. While this effect is well-established, the mechanism behind it remains elusive. Myriad hypotheses have been suggested, but few experiments have helped narrow the field of possible explanations. In addition, the complex visual features of real zebra pelage and the natural range of stripe widths have been largely left out of experimental designs. In paired-choice field experiments in a Kenyan savannah, we found that hungry Stomoxys flies released in an enclosure strongly preferred to land on uniform tan impala pelts over striped zebra pelts but exhibited no preference between the pelts of the zebra species with the widest stripes and the narrowest stripes. Our findings confirm that zebra stripes repel biting flies under naturalistic conditions and do so at close range (suggesting that several of the mechanisms hypothesized to operate at a distance are unnecessary for the fly-repulsion effect) but indicate that interspecific variation in stripe width is associated with selection pressures other than biting flies.
A case study of a real-time internet of things system for site-specific potato crop management in El-Salhia Area-Egypt
Authors: Mohammad EL-Basioni Basma M. , Mohamed Elsayed Said , Belal AA. , Jalhoum Mohamed E. M. , Abd EL-Kader Sherine M. , Zahran Mohamed B.
Published: November 2022

The site-specific management is the technology that considers the natural variability within the same field of factors related to crop growth to improve its management practices such that the agricultural treatments are varied for field's small production zones saving resources and environment, and improving crop quality and size. Since site-specific decisions are not far from the Fourth Industrial Revolution and the concept of processes automation, this work addresses improving the process of spatial variability analysis and thus supporting management decisions by developing a system—entitled EGYPADS—based on the Internet of Things and its enabling technologies. EGYPADS automates data collection, zones delineation according to their land suitability evaluation, and maps generation. The paper addresses a case study of potato crop in a specific area in Egypt, El-Salhia, in which eighty-five sites were chosen as main dataset for the modeling process during different stages of crop growth. Three management zones were recognized of the selected field based on the differentiation in their land suitability characteristics, representing about 5%, 65%, and 30% of the total area, respectively. The structure, screens, and services of EGYPADS are described in this paper. EGYPADS offered services include: management zones delineation using absolute and virtual coordinates, Land Suitability Assessment (LSA), data entry from field in real-time as well as from excel sheets, saving maps in suitable format for variable rate application, real-time and historical data processing, centralized management, and flexible formulation of events and related actions. The implementation of EGYPADS was verified. The system dynamically produces non-contiguous isobands, each representing a specific range of parameter values, and can be properly exported for use by other programs or smart machinery. It was proven that EGYPADS supports more than one land with different geometry, area, location, and number of nodes. EGYPADS was compared with the traditional LSA method, and was found to produce similar management zones.
DeepFake knee osteoarthritis X-rays from generative adversarial neural networks deceive medical experts and offer augmentation potential to automatic classification
Authors: Prezja Fabi , Paloneva Juha , Pölönen Ilkka , Niinimäki Esko , Äyrämö Sami
Published: November 2022

Recent developments in deep learning have impacted medical science. However, new privacy issues and regulatory frameworks have hindered medical data sharing and collection. Deep learning is a very data-intensive process for which such regulatory limitations limit the potential for new breakthroughs and collaborations. However, generating medically accurate synthetic data can alleviate privacy issues and potentially augment deep learning pipelines. This study presents generative adversarial neural networks capable of generating realistic images of knee joint X-rays with varying osteoarthritis severity. We offer 320,000 synthetic (DeepFake) X-ray images from training with 5,556 real images. We validated our models regarding medical accuracy with 15 medical experts and for augmentation effects with an osteoarthritis severity classification task. We devised a survey of 30 real and 30 DeepFake images for medical experts. The result showed that on average, more DeepFakes were mistaken for real than the reverse. The result signified sufficient DeepFake realism for deceiving the medical experts. Finally, our DeepFakes improved classification accuracy in an osteoarthritis severity classification task with scarce real data and transfer learning. In addition, in the same classification task, we replaced all real training data with DeepFakes and suffered only a$$3.79\%$$3.79%loss from baseline accuracy in classifying real osteoarthritis X-rays.
Precision gynecologic oncology: circulating cell free DNA epigenomic analysis, artificial intelligence and the accurate detection of ovarian cancer
Authors: Bahado-Singh Ray O. , Ibrahim Amin , Al-Wahab Zaid , Aydas Buket , Radhakrishna Uppala , Yilmaz Ali , Vishweswaraiah Sangeetha
Published: November 2022

Ovarian cancer (OC) is the most lethal gynecologic cancer due primarily to its asymptomatic nature and late stage at diagnosis. The development of non-invasive markers is an urgent priority. We report the accurate detection of epithelial OC using Artificial Intelligence (AI) and genome-wide epigenetic analysis of circulating cell free tumor DNA (cfTDNA). In a prospective study, we performed genome-wide DNA methylation profiling of cytosine (CpG) markers. Both conventional logistic regression and six AI platforms were used for OC detection. Further, we performed Gene Set Enrichment Analysis (GSEA) analysis to elucidate the molecular pathogenesis of OC. A total of 179,238 CpGs were significantly differentially methylated (FDR p-value < 0.05) genome-wide in OC. High OC diagnostic accuracies were achieved. Conventional logistic regression achieved an area under the ROC curve (AUC) [95% CI] 0.99 [± 0.1] with 95% sensitivity and 100% specificity. Multiple AI platforms each achieved high diagnostic accuracies (AUC = 0.99–1.00). For example, for Deep Learning (DL)/AI AUC = 1.00, sensitivity = 100% and 88% specificity. In terms of OC pathogenesis: GSEA analysis identified ‘Adipogenesis’ and ‘retinoblastoma gene in cancer’ as the top perturbed molecular pathway in OC. This finding of epigenomic dysregulation of molecular pathways that have been previously linked to cancer adds biological plausibility to our results.
Gapped electron liquid state in the symmetric Anderson lattice, Kondo insulator state
Authors: Karnaukhov Igor N.
Published: November 2022

The Kondo insulator state (KIS) realized in the symmetric Anderson model at half filling is studied in the framework of a mean field approach. It is shown that the state of the Kondo insulator is realized in a lattice with a double cell and a gapped electron liquid behaves like a gapless Majorana spin liquid. The local moments of d-electrons form a static $$Z_2$$

Z
2

-field in which band electrons move. The gap value in the quasi-particle excitations spectrum decreases with increasing an external magnetic field and closes at its critical value. The behavior of an electron liquid is studied for an arbitrary dimension of the model. The proposed approach leads to the description of KIS without the need to resort to artificial symmetry breaking to alternative understanding of the physical nature of this phase state.
Phenome-wide analysis of Taiwan Biobank reveals novel glycemia-related loci and genetic risks for diabetes
Authors: Lee Chia-Jung , Chen Ting-Huei , Lim Aylwin Ming Wee , Chang Chien-Ching , Sie Jia-Jyun , Chen Pei-Lung , Chang Su-Wei , Wu Shang-Jung , Hsu Chia-Lin , Hsieh Ai-Ru , Yang Wei-Shiung , Fann Cathy S. J.
Published: November 2022

To explore the complex genetic architecture of common diseases and traits, we conducted comprehensive PheWAS of ten diseases and 34 quantitative traits in the community-based Taiwan Biobank (TWB). We identified 995 significantly associated loci with 135 novel loci specific to Taiwanese population. Further analyses highlighted the genetic pleiotropy of loci related to complex disease and associated quantitative traits. Extensive analysis on glycaemic phenotypes (T2D, fasting glucose and HbA1c) was performed and identified 115 significant loci with four novel genetic variants (HACL1,RAD21,ASH1LandGAK). Transcriptomics data also strengthen the relevancy of the findings to metabolic disorders, thus contributing to better understanding of pathogenesis. In addition, genetic risk scores are constructed and validated for absolute risks prediction of T2D in Taiwanese population. In conclusion, our data-driven approach without a priori hypothesis is useful for novel gene discovery and validation on top of disease risk prediction for unique non-European population.