bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

XLSX file - 10K, Clinical characteristics of patients analyzed by RNAseq.
Supplementary Figure 2 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: March 2023

PDF file - 766K, TaqMan validation of RNAseq data. Taqman Fold Change was calculated for three genes (PTN, SYNM, and TMSB10) and plotted against FPKM values.
Supplementary Figure 4 from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: March 2023

PDF file - 4341K, Incubation of B cells with anti-JAM-C antibodies does not affect expression of activation markers or adhesion molecules
Supplementary Figure 2 from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: March 2023

PDF file - 6982K, Analysis of human B cell migration to lymphoid organs of NOD/SCID mice
Supplementary Materials and Methods from Regulation of Lung Cancer Metastasis by Klf4-Numb–like Signaling
Authors: Vaira Valentina , Faversani Alice , Martin Nina M. , Garlick David S. , Ferrero Stefano , Nosotti Mario , Kissil Joseph L. , Bosari Silvano , Altieri Dario C.
Published: March 2023

PDF File - 4789K, REGULATION OF LUNG CANCER METASTASIS BY Klf4-Numb-like SIGNALING.
Supplementary Figure 4 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Authors: Russell Mike R. , Levin Kirill , Rader JulieAnn , Belcastro Lili , Li Yimei , Martinez Daniel , Pawel Bruce , Shumway Stuart D. , Maris John M. , Cole Kristina A.
Published: March 2023

PDF file - 126K, Dual inhibition of Chk1 and Wee1 significantly impairs tumor growth in vivo. Mice were treated with either 30 mg/kg of single agent MK-1775 (targeting Wee1), single-agent MK-8776 (targeting Chk1) or simultaneous MK-1775 and MK-8776. Mixed linear effects model was used to calculate the rate of tumor growth in each condition, and demonstrated that dual inhibition was efficacious in both SKNAS and NB1643 xenograft models. Mice harboring NB1643 xenografts were treated for 48h, tumors were resected and target engagement was validated by western blot analysis
Supplementary Figure 3 from Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
Authors: Russell Mike R. , Levin Kirill , Rader JulieAnn , Belcastro Lili , Li Yimei , Martinez Daniel , Pawel Bruce , Shumway Stuart D. , Maris John M. , Cole Kristina A.
Published: March 2023

PDF file - 128K, Target engagement was validated for several cell lines via western blot analyses. Here, RPE-1, SK-N-AS, KELLY and NB-1691 cells are shown following treatment with increasing concentrations of MK-8776 and MK-1775 for 16h. Inhibition of Chk1 (via MK-8776) and Cdc2 phosphorylation (via MK-1775) was observed in sensitive cell lines
Supplementary Movie 1 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: March 2023

MOV file - 1613K, Examples of a high quality (left) and a low quality (right) EB3-GFP movie (raw data), acquisition of 125 frames, 1.25 Hz, 10 fold accelerated.
Supplementary Table 1, Figures 1 - 2 from Imatinib Radiosensitizes Bladder Cancer by Targeting Homologous Recombination
Authors: Qiao Boling , Kerr Martin , Groselj Blaz , Teo Mark T.W. , Knowles Margaret A. , Bristow Robert G. , Phillips Roger M. , Kiltie Anne E.
Published: March 2023

PDF file - 287K, Supplementary Table 1. Target regions for Ku80 and RAD51 siRNA. Supplementary Figure 1. Western blots of Ku80 and RAD51 in RT112 stable shRNA clones. Supplementary Figure 2. Full length western blots.
Supplementary Figure 2 from Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer
Authors: Khalaileh Abed , Dreazen Avigail , Khatib Areej , Apel Roy , Swisa Avital , Kidess-Bassir Norma , Maitra Anirban , Meyuhas Oded , Dor Yuval , Zamir Gideon
Published: March 2023

PDF file - 47K, Mosaic phosphorylation of rpS6 in wild type islets.
Supplementary Figure 3 from RNA Trafficking by Acute Myelogenous Leukemia Exosomes
Authors: Huan Jianya , Hornick Noah I. , Shurtleff Matthew J. , Skinner Amy M. , Goloviznina Natalya A. , Roberts Charles T. , Kurre Peter
Published: March 2023

PDF file - 156K, AML exosomes can alter gene expression and protein secretion
Supplementary Materials and Methods from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: March 2023

PDF file - 136KB
Supplementary Methods and Figure Legends from PARI Overexpression Promotes Genomic Instability and Pancreatic Tumorigenesis
Authors: O'Connor Kevin W. , Dejsuphong Donniphat , Park Eunmi , Nicolae Claudia M. , Kimmelman Alec C. , D'Andrea Alan D. , Moldovan George-Lucian
Published: March 2023

PDF file - 62K, Supplemental Materials and Methods, including: Antibodies, Gene knockdown by siRNA, and Histology.
Supplementary Figures 1 - 11 from PARI Overexpression Promotes Genomic Instability and Pancreatic Tumorigenesis
Authors: O'Connor Kevin W. , Dejsuphong Donniphat , Park Eunmi , Nicolae Claudia M. , Kimmelman Alec C. , D'Andrea Alan D. , Moldovan George-Lucian
Published: March 2023

PDF file - 2404K, Supplementary Figures 1-11; Supplementary Figure 1: Representative micrographs showing a decrease in IR-induced RAD51 foci in PARI-overexpressing 8988T and CAPAN2 cells. Supplementary Figure 2: PARI-overexpressing pancreatic cancer cell line 8988T is hypersensitive to PARP inhibitor ABT-888. Supplementary Figure 3: SupF-based mutagenesis assay showing increased point mutations in 293T cells overexpressing Myc-PARI at high levels. Supplementary Figure 4: Analysis of chromosome morphology in metaphase spreads of 8988T cells, showing that PARI knockdown reduces chromosomal aberrations following exposure to 20ng/ml MMC. Supplementary Figure 5: PARI depletion reduces viability of PARI-overexpressing cells (CAPAN2), but does not affect the cells that do not overexpress it (CAPAN1, HeLa, 293T). Supplementary Figure 6: PARI knockdown leads to a significant increase in the S-phase fraction. Supplementary Figure 7: FACS analysis of 8988T cells treated with HU, followed by release in fresh media. Supplementary Figure 8: PARI depletion in CAPAN2 (pancreatic cancer cells overexpressing PARI) results in HU sensitivity. Supplementary Figure 9: Depletion of PARI by shRNA decreases cellular proliferation when grown in the presence of 20μg/ml doxycyline. Supplementary Figure 10: H&E stain of paraffin-embedded slides showing increased necrosis in xenograft tumors originating from PARI-depleted 8988T cells. Supplementary Figure 11: Model of PARI-dependent DNA repair regulation in pancreatic cancer cells.
Supplementary Figure 6 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: March 2023

PDF file - 275KB, GDF15/MIC-1 serum levels correlate with "responder" tumor growth.
Supplementary Figure 1 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: March 2023

PDF file - 114KB, GDF15/MIC-1 expression in prostate tumor tissue.
Supplementary Table 1 from Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways
Authors: Sawant Anandi , Schafer Cara C. , Jin Tong Huan , Zmijewski Jaroslaw , Tse Hubert M. , Roth Justin , Sun Zhihuan , Siegal Gene P. , Thannickal Victor J. , Grant Stefan C. , Ponnazhagan Selvarangan , Deshane Jessy S.
Published: March 2023

PDF file - 18K, Antibodies used for characterization of Immune Cell Phenotypes.
Supplementary Figures 1 - 7 from Enhancement of Antitumor Immunity in Lung Cancer by Targeting Myeloid-Derived Suppressor Cell Pathways
Authors: Sawant Anandi , Schafer Cara C. , Jin Tong Huan , Zmijewski Jaroslaw , Tse Hubert M. , Roth Justin , Sun Zhihuan , Siegal Gene P. , Thannickal Victor J. , Grant Stefan C. , Ponnazhagan Selvarangan , Deshane Jessy S.
Published: March 2023

PDF file - 381K, The phenotype of MDSC in the lung and spleen from lung cancer challenged mice (S1); Reduced tumor burden in mice from Gem and SODmim+Gem therapy groups (S2); Combination therapy reduced infiltration of neutrophils but not macrophages in tumor (S3); Combination therapy was efficient in reducing tumor growth in catalase deficient mice by decreasing MDSC infiltration and improving the memory CD8+ T cell response (S4); Persistent memory CD8+ T cell subsets expand following re-encounter with i.v. challenged LLC cells (S5); Adoptively transferred memory cells persist and reduce MDSC infiltration and tumor burden in LLC-rechallenged recipient mice (S6); Adoptively transferred memory cells expand upon encounter with tumor cells (S7).
Supplementary Figure 7 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: March 2023

PDF File - 106K, Knockdown of SCD1 does not alter cholesterol homeostasis.
Supplementary Figure 6 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: March 2023

PDF File - 112K, Expression of mature SREBP1 alters the ratio of saturated to monounsaturated fatty acids.
Supplementary Figure 6 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: March 2023

PDF file - 106K, The expression of chemokine receptors by BM-derived macrophages
Supplementary Figure 4 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: March 2023

PDF file - 76K, Chemokines in the supernatant of tumor cell lines
Figure Legends from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: March 2023

PDF File - 118K, Legends for Supplementary Figures 1-8.
Supplementary Figure 4 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 85K, Pubertal development of the mammary gland is unaffected by Bcl3 deletion
Supplementary Figure 3 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 193K, Bcl3 deficiency has no effect on pre-neoplastic tissue homeostasis
Supplementary Figure 2 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: March 2023

PDF file - 269K, Primary tumour morphology and cell turnover kinetics are unaltered by Bcl3 deficiency
Supplementary Methods from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: March 2023

PDF file - 33K, SUPPLEMENTARY R SCRIPT: R script and code that can be employed to generate all results described in the manuscript.
Supplementary Figures 1 - 3 from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: March 2023

PDF file - 2863K, Impact of unevenly distributed resistance mechanisms between training and test sets on signature performance (S1); Impact of different distributions of resistance mechanisms in training and test sets on signature performance (S2); Impact of cohort sub-stratification on signature performance (S3).
Supplementary Methods from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Authors: Song Qiancheng , Xu Yuanfei , Yang Cuilan , Chen Zhenguo , Jia Chunhong , Chen Juan , Zhang Yue , Lai Pinglin , Fan Xiaorong , Zhou Xuan , Lin Jun , Li Ming , Ma Wenli , Luo Shenqiu , Bai Xiaochun
Published: March 2023

PDF file - 184KB
Supplementary Tables 1 - 4 from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: March 2023

PDF file - 516K, T1. Breast cell lines used in this study. T2. Summary of results for 45 breast cancer cell lines and 5 non-malignant cell lines. T3. Correlation of hTERT α/β splice variants, telomerase activity, telomere length and hTR in 50 breast cancer cell lines. T4. Sequences of primers used.
Supplementary Figures 1 - 7 from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: March 2023

PDF file - 579K, Supplemantary Figure 1: Bcl-2 and Bcl-xL determine sensitivity to PI3K/AKT/mTOR inhibition. Supplementary Figure 2: AKT modulates sensitivity to ABT-737. Supplementary Figure 3: BEZ235/ABT-737 results in time-dependent induction of apoptosis. Supplementary Figure 4: PI3K inhibitors markedly increase Bim binding to Bcl-2 and Bcl-xL. Supplementary Figure 5: Overexpression of Bcl-2 or Bcl-xL protects leukemia cells against BEZ235/ABT-737 lethality Supplementary Figure 6: GSK3 inhibitors protect cells against BEZ235/ABT-737 lethality Supplementary Figure 7: In vivo anti-leukemic activity of BEZ235/ABT-737.
Supplementary Methods from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: March 2023

PDF file - 56K
Supplementary Figures 1 - 9 from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: March 2023

PDF file - 236K, S1. hTERT and SRSF3 splice variant enrichment after cycloheximide treatment. S2. Total SRSF3 and hTERT splice variant mRNA abundance in ribosome-containing fractions. S3. Unaltered microscopy image shown in Figure 3. S4. SRSF11 and hnRNPH2 binding sites in pSpliceExpress-hTERT. S5. hTR 3' end co-immunoprecipitates with FLAG-WT-hTERT, FLAG-D868A-hTERT and FLAG-β-deletion. S6. hTERT detection by Western blot in UM-UC-3 lysates from experiment 5C. S7. hTR RNA expression levels in breast cancer cell lines. S8. Modal telomere length stayed relatively constant after 20 continues passages in randomly selected breast cell lines. S9. Telomerase activity and relative expression of hTERT α+β+ and β-deletion mRNAs in breast cancer cell line subtypes.
Supplementary Figure Legend from The Major Reverse Transcriptase–Incompetent Splice Variant of the Human Telomerase Protein Inhibits Telomerase Activity but Protects from Apoptosis
Authors: Listerman Imke , Sun Jie , Gazzaniga Francesca S. , Lukas Jason L. , Blackburn Elizabeth H.
Published: March 2023

PDF file - 45K
Supplementary Pairwise Interactions 1 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: March 2023

XLSX file - 5261K
Supplementary Figures 1 - 5, Table 1 from EGFR-TKI Resistance Due to BIM Polymorphism Can Be Circumvented in Combination with HDAC Inhibition
Authors: Nakagawa Takayuki , Takeuchi Shinji , Yamada Tadaaki , Ebi Hiromichi , Sano Takako , Nanjo Shigeki , Ishikawa Daisuke , Sato Mitsuo , Hasegawa Yoshinori , Sekido Yoshitaka , Yano Seiji
Published: March 2023

PDF file - 785K, Supplementary Figure 1. Expression of total BIM and ratio of BIM isoforms in NSCLC cell lines. Supplementary Figure 2. Flow cytometric analysis showing that EGFR mutated cell lines carrying the BIM polymorphism have low susceptibility to gefitinib-induced apoptosis. Supplementary Figure 3. Vorinostat-induced up-regulation of BIM enhances apoptosis in the HCC2279 cell line with the BIM polymorphism.Supplementary Figure 4. Knockdown or overexpression of BIM affects activation of caspase-3/7 induced by gefitinib and vorinostat in EGFR mutant cells with BIM polymorphism. Supplementary Figure 5. Detection of BIM polymorphism in human peripheral blood mononuclear cells (PBMC) and serum. Supplementary Table 1. Status of EGFR mutation and BIM polymorphism in NSCLC cell lines.
Supplementary Table 1 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: March 2023

XLSX file - 170K, Supplementary Table 1: Results of the first siRNA screen aimed at identifying new EMT regulators among protein kinases Supplementary Table 2: Selected pro-MET genes from the first siRNA screen Supplementary Table 3: Selected pro-EMT genes from the first siRNA screen Supplementary Table 4: Selected pro-MET genes challenged with 2 additional siRNAs Supplementary Table 5: Selected pro-EMT genes challenged with 2 additional siRNAs
Supplementary Figure 4 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: March 2023

PDF file - 1195K, Supplementary Figure 4: RPTOR and mTOR silencing impair S6K phosphorylation.
Supplementary Figure 3 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: March 2023

PDF file - 6734K, Supplementary Figure 3: Consequences of mTOR inhibition on epithelial integrity.
Supplementary Figure 2 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: March 2023

PDF file - 848K, Supplementary Figure 2: Inhibition of mTORC1 activates EMT and reduces cell proliferation.
Suppl Table 2 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: March 2023

Suppl Table 2
Supplementary Figure 3 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: March 2023

PDF file - 89K, Knockdown of endogenous deltaNp63 in neuroblastoma and osteosarcoma cell lines reduces cell proliferation and colony formation.
Supplementary Figure 1 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: March 2023

PDF file - 158K, mRNA expression analysis of deltaNp63 isoforms in Childhood Tumors.
Supplementary Table 2 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: March 2023

PDF file - 65KB, Bacterial sequence homologies for IGFBP-2 C-terminus.
Supplementary Table 1 from Elimination of IL-10–Inducing T-Helper Epitopes from an IGFBP-2 Vaccine Ensures Potent Antitumor Activity
Authors: Cecil Denise L. , Holt Gregory E. , Park Kyong Hwa , Gad Ekram , Rastetter Lauren , Childs Jennifer , Higgins Doreen , Disis Mary L.
Published: March 2023

PDF file - 15KB, Primer sequences and PCR conditions for the indicated construct.
Supplementary Figure Legends from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Authors: Colbert Lauren E. , Petrova Aleksandra V. , Fisher Sarah B. , Pantazides Brooke G. , Madden Matthew Z. , Hardy Claire W. , Warren Matthew D. , Pan Yunfeng , Nagaraju Ganji P. , Liu Elaine A. , Saka Burcu , Hall William A. , Shelton Joseph W. , Gandhi Khanjan , Pauly Rini , Kowalski Jeanne , Kooby David A. , El-Rayes Bassel F. , Staley Charles A. , Adsay N. Volkan , Curran Walter J. , Landry Jerome C. , Maithel Shishir K. , Yu David S.
Published: March 2023

PDF file - 70KB
Supplementary Table 3 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: March 2023

XLSX file - 613K, Genes significantly downregulated in samples with either CUL3 or NRF2 mutations
Supplementary Figure 5 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: March 2023

PDF file - 718K, In vitro viability of NB4 and MDA-MB-231 cells � NTR � MTZ.
Supplementary Figure 2 from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: March 2023

PDF file - 36K, Blocking surface PD-1/PD-L1 did not effect the cytotoxic capacity of PD-1 negative, PD-L1 specific T cells
Supplementary Figure 1 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: March 2023

PDF file - 65K, A. Lysates from control (pLKO1) or PIP4k2B (shPIP4k2B) knockdown MCF10A cells were immunoblotted using the PIP4K2BP6 antibody. B. The PIP4K2BP6 antibody was immunodepleted by passing it through a column to which the P6 antigenic peptide was coupled. The antibody before or after, as indicated, was used to probe western blots of increasing levels of PIP4K2B .
Supplementary Figure 3 from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: March 2023

PDF file - 1482K, Supplementary Figure 3: A. Representative photographs showing histological evaluation of desmoplastic activity on orthotopic pancreatic cancer mouse models. B. Evaluation of the PCNA index (%). C. Representative photographs showing nodules of liver metastasis on the surface of the liver.
Supplementary Figure 5 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: March 2023

PDF file - 1099K, p-Trask immunostain of wounded mouse skin
Supplementary Figure 7 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: March 2023

PDF file - 372K, iNGR enhances tumor penetration of Evans Blue dye
Supplementary Movie 8 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

MOV file - 2608K, Motility S2-013.M.4A
Supplementary Figure 2 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

KM curve of 100 cell injection, quantization of Ki67 and Casp3 staining, and self-renewal of TICs.
Supplementary Figure 1 from Epigenetic States of Cells of Origin and Tumor Evolution Drive Tumor-Initiating Cell Phenotype and Tumor Heterogeneity
Authors: Chow Kin-Hoe , Shin Dong-Mi , Jenkins Molly H. , Miller Emily E. , Shih David J. , Choi Seungbum , Low Benjamin E. , Philip Vivek , Rybinski Brad , Bronson Roderick T. , Taylor Michael D. , Yun Kyuson
Published: March 2023

KM survival curve, quantitation of differentiated cells, and H&E of tumorsphere induced tumors.
Supplementary Methods from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

PDF file - 129K
Supplementary Figure 2 from Interactions between MUC1 and p120 Catenin Regulate Dynamic Features of Cell Adhesion, Motility, and Metastasis
Authors: Liu Xiang , Yi Chunhui , Wen Yunfei , Radhakrishnan Prakash , Tremayne Jarrod R. , Dao Thongtan , Johnson Keith R. , Hollingsworth Michael A.
Published: March 2023

PDF file - 126K, Expression levels of E-cadherin upon re-expression of different p120 catenin isoforms in the context of with/without MUC1 overexpression. Protein lysates for western blots were derived from S2-013.Neo (deficient in p120 catenin) and p120 catenin isoform re-expressing cells with/without MUC1 overexpression.
Supplemental Data from Auranofin Induces Lethal Oxidative and Endoplasmic Reticulum Stress and Exerts Potent Preclinical Activity against Chronic Lymphocytic Leukemia
Authors: Fiskus Warren , Saba Nakhle , Shen Min , Ghias Mondana , Liu Jinyun , Gupta Soumyasri Das , Chauhan Lata , Rao Rekha , Gunewardena Sumedha , Schorno Kevin , Austin Christopher P. , Maddocks Kami , Byrd John , Melnick Ari , Huang Peng , Wiestner Adrian , Bhalla Kapil N.
Published: March 2023

Supplemental Figure 1: Chemical structures of the molecules utilized in this study. Supplemental Table 1: Characteristics of the primary CLL cells utilized in these studies. Supplemental Figure 2: Apoptosis of CLL cells with AF and NAC. Supplemental Figure 3: AF effects on nurse-like cells (NLCs). Supplemental Table 2: Leukemia cell burden in TCL-1 mice pre and post treatment with AF. Supplemental Table 3: Gene expression changes in CLL cells after 8 hrs of AF treatment. Supplemental Table 4: Ingenuity Pathway Analysis of perturbed networks in Primary CLL cells after AF treatment. Supplemental Figure 4: IPA analysis of connected networks in CLL cells. Supplemental Figure 5: Synergy of AF with BSO or Zn-BG in CLL cells. Supplemental Figure 6: Hydrogen peroxide mediated effects on ROS, ER stress and apoptosis in CLL cells.
Supplementary Figure 6 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 243K, Supplemental Figure 6. ZEB1 mediates CUL4A-induced EMT, stemness and metastasis.
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Table S1. Comparison of fold change of gene expression in ADAM9 knockdown and brain-metastatic cell sublines (Bm2 and Bm7) with parental cells.
Supplementary Figure 4 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 275K, Supplemental Figure 4. Representative images of immunostaining and quantification of Ki67 positive cells in xenograft tumors formed from MDA-MB 468 CUL4 (A) and MDA-MB 231 shCUL4A (B) cells.
Supplementary Figure 2 from CUL4A Induces Epithelial–Mesenchymal Transition and Promotes Cancer Metastasis by Regulating ZEB1 Expression
Authors: Wang Yunshan , Wen Mingxin , Kwon Yongwon , Xu Yangyang , Liu Yueyong , Zhang Pengju , He Xiuquan , Wang Qin , Huang Yurong , Jen Kuang-Yu , LaBarge Mark A. , You Liang , Kogan Scott C. , Gray Joe W. , Mao Jian-Hua , Wei Guangwei
Published: March 2023

PDF file - 156K, Supplemental Figure 2. CUL4A regulates the transition between epithelial and mesenchymal phenotypes in human normal mammary and cancer cells.
Data Supplement from ADAM9 Promotes Lung Cancer Metastases to Brain by a Plasminogen Activator-Based Pathway
Authors: Lin Chen-Yuan , Chen Hung-Jen , Huang Cheng-Chung , Lai Liang-Chuan , Lu Tzu-Pin , Tseng Guan-Chin , Kuo Ting-Ting , Kuok Qian-Yu , Hsu Jennifer L. , Sung Shian-Ying , Hung Mien-Chie , Sher Yuh-Pyng
Published: March 2023

Supplementary Methods and References. Description of additional methods and procedures used in the study. Also includes supplementary references.
Supplementary Methods, Figure Legend from FGFR1–WNT–TGF-β Signaling in Prostate Cancer Mouse Models Recapitulates Human Reactive Stroma
Authors: Carstens Julienne L. , Shahi Payam , Van Tsang Susan , Smith Billie , Creighton Chad J. , Zhang Yiqun , Seamans Amber , Seethammagari Mamatha , Vedula Indira , Levitt Jonathan M. , Ittmann Michael M. , Rowley David R. , Spencer David M.
Published: March 2023

PDF file - 122K
Supplementary Methods from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 115KB
Supplementary Figure Legend from Cell Fate Factor DACH1 Represses YB-1–Mediated Oncogenic Transcription and Translation
Authors: Wu Kongming , Chen Ke , Wang Chenguang , Jiao Xuanmao , Wang Liping , Zhou Jie , Wang Jing , Li Zhiping , Addya Sankar , Sorensen Poul H. , Lisanti Michael P. , Quong Andrew , Ertel Adam , Pestell Richard G.
Published: March 2023

PDF file - 86K
Supplementary Figure 4 from Activated ERBB2/HER2 Licenses Sensitivity to Apoptosis upon Endoplasmic Reticulum Stress through a PERK-Dependent Pathway
Authors: Martín-Pérez Rosa , Palacios Carmen , Yerbes Rosario , Cano-González Ana , Iglesias-Serret Daniel , Gil Joan , Reginato Mauricio J. , López-Rivas Abelardo
Published: March 2023

PDF file - 82KB, Role of CHOP in the regulation of TRAIL-R2 expression by thapsigargin in NeuT cells.
Supplementary Table 1 from Histone Chaperone CHAF1A Inhibits Differentiation and Promotes Aggressive Neuroblastoma
Authors: Barbieri Eveline , De Preter Katleen , Capasso Mario , Chen Zaowen , Hsu Danielle M. , Tonini Gian Paolo , Lefever Steve , Hicks John , Versteeg Rogier , Pession Andrea , Speleman Frank , Kim Eugene S. , Shohet Jason M.
Published: March 2023

XLSX file - 17K, Gene Ontology (GO) analysis of gene sets regulated by Cyclin D1 and CDK4 silencing.
Supplementary Figure 1 from p16INK4a Impairs Homologous Recombination–Mediated DNA Repair in Human Papillomavirus–Positive Head and Neck Tumors
Authors: Dok Rüveyda , Kalev Peter , Van Limbergen Evert Jan , Asbagh Layka Abbasi , Vázquez Iria , Hauben Esther , Sablina Anna , Nuyts Sandra
Published: March 2023

PDF file - 43KB, Effect of p16/INK4A on plating efficiency.
Supplementary Tables 1 - 5 from p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Authors: Shi Lei , Jackstadt Rene , Siemens Helge , Li Huihui , Kirchner Thomas , Hermeking Heiko
Published: March 2023

PDF file - 43K, Supplementary Table 1. Oligonucleotides used for cloning and site-directed mutagenesis Supplementary Table 2. Oligonucleotides used for qChIP analyses Supplementary Table 3. Antibodies used for Western blot (WB) and immunofluorescence (IF) analysis Supplementary Table 4. Oligonucleotides used for qPCR analyses Supplementary Table 5. Sub-analysis using cases with the most prominent miR-15a expression levels.
Supplementary Figure Legend from Unbiased Compound Screening Identifies Unexpected Drug Sensitivities and Novel Treatment Options for Gastrointestinal Stromal Tumors
Authors: Boichuk Sergei , Lee Derek J. , Mehalek Keith R. , Makielski Kathleen R. , Wozniak Agnieszka , Seneviratne Danushka S. , Korzeniewski Nina , Cuevas Rolando , Parry Joshua A. , Brown Matthew F. , Zewe James , Taguchi Takahiro , Kuan Shin-Fan , Schöffski Patrick , Debiec-Rychter Maria , Duensing Anette
Published: March 2023

PDF - 83K, Legend for Supplementary Figures S1-S3 and Supplementary Table S1.
Supplementary Figures 1 - 8 from IGF-I Regulates Redox Status in Breast Cancer Cells by Activating the Amino Acid Transport Molecule xC−
Authors: Yang Yuzhe , Yee Douglas
Published: March 2023

PDF file - 669KB, Supplemental Figures 1-8 with annotation S1. siRNA titration in MCF-7 cells. S2. IGF-I induced xCT mRNA and protein expression specifically through IRS-1 in T47D and ZR-75-1 cells. S3. Inhibition of IGF- signaling. S4. Effect of SASP, BSO, and NAC concentration on growth. S5. IGF-I regulated intracellular ROS level via xC- transporter in MCF-7 and T47D cells but not in MDA-MB-231 cells. S6. xCT shRNA downregulation in MCF-7 cells. S7. Ligands of the insulin/IGF system stimulated xCT mRNA expression but not CD44v mRNA expression in MCF-7 cells. S8. BSO mediated cellular behaviors assays in MCF-7 cells.
Supplementary Figure 4 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
Authors: Allen Michael D. , Luong Phuong , Hudson Chantelle , Leyton Julius , Delage Barbara , Ghazaly Essam , Cutts Rosalind , Yuan Ming , Syed Nelofer , Lo Nigro Cristiana , Lattanzio Laura , Chmielewska-Kassassir Malgorzata , Tomlinson Ian , Roylance Rebecca , Whitaker Hayley C. , Warren Anne Y. , Neal David , Frezza Christian , Beltran Luis , Jones Louise J. , Chelala Claude , Wu Bor-Wen , Bomalaski John S. , Jackson Robert C. , Lu Yong-Jie , Crook Tim , Lemoine Nicholas R. , Mather Stephen , Foster Julie , Sosabowski Jane , Avril Norbert , Li Chien-Feng , Szlosarek Peter W.
Published: March 2023

PDF file - 177K, Kaplan-Meier plot and log-rank test for disease-specific and metastasis-free survival.
Supplementary Figure 3 from Prognostic and Therapeutic Impact of Argininosuccinate Synthetase 1 Control in Bladder Cancer as Monitored Longitudinally by PET Imaging
Authors: Allen Michael D. , Luong Phuong , Hudson Chantelle , Leyton Julius , Delage Barbara , Ghazaly Essam , Cutts Rosalind , Yuan Ming , Syed Nelofer , Lo Nigro Cristiana , Lattanzio Laura , Chmielewska-Kassassir Malgorzata , Tomlinson Ian , Roylance Rebecca , Whitaker Hayley C. , Warren Anne Y. , Neal David , Frezza Christian , Beltran Luis , Jones Louise J. , Chelala Claude , Wu Bor-Wen , Bomalaski John S. , Jackson Robert C. , Lu Yong-Jie , Crook Tim , Lemoine Nicholas R. , Mather Stephen , Foster Julie , Sosabowski Jane , Avril Norbert , Li Chien-Feng , Szlosarek Peter W.
Published: March 2023

PDF file - 315K, Immunostaining of ASS1, TS, and DHFR in representative urothelial carcinomas.
Supplementary Figure 6 from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 128KB, Correlation between p300 and phosphorylated AKT (AKT-p) in human PCa specimens.
Supplementary Figure 1 from p300 Acetyltransferase Regulates Androgen Receptor Degradation and PTEN-Deficient Prostate Tumorigenesis
Authors: Zhong Jian , Ding Liya , Bohrer Laura R. , Pan Yunqian , Liu Ping , Zhang Jun , Sebo Thomas J. , Karnes R. Jeffrey , Tindall Donald J. , van Deursen Jan , Huang Haojie
Published: March 2023

PDF file - 200KB, Generation of prostate-specific p300 deletion mice.
Supplementary Table 2 from Small Molecule Agonists of PPAR-γ Exert Therapeutic Effects in Esophageal Cancer
Authors: Sawayama Hiroshi , Ishimoto Takatsugu , Watanabe Masayuki , Yoshida Naoya , Sugihara Hidetaka , Kurashige Junji , Hirashima Kotaro , Iwatsuki Masaaki , Baba Yoshifumi , Oki Eiji , Morita Masaru , Shiose Yoshinobu , Baba Hideo
Published: March 2023

PDF file - 112K, PPARγ status in ESCC and patient mortality.
Supplementary Figure Legend from Small Molecule Agonists of PPAR-γ Exert Therapeutic Effects in Esophageal Cancer
Authors: Sawayama Hiroshi , Ishimoto Takatsugu , Watanabe Masayuki , Yoshida Naoya , Sugihara Hidetaka , Kurashige Junji , Hirashima Kotaro , Iwatsuki Masaaki , Baba Yoshifumi , Oki Eiji , Morita Masaru , Shiose Yoshinobu , Baba Hideo
Published: March 2023

PDF file - 107K
Supplementary Figure S1 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: March 2023

Both aLIMD2 (rAb) and aLIMD2 (mAb) detected the exogenous and endogenous LIMD2 protein in cell lines and human cancer specimens.
Supplementary Figures 1 - 6, Table 1 from Endothelial-Specific Notch Blockade Inhibits Vascular Function and Tumor Growth through an eNOS-Dependent Mechanism
Authors: Patenaude Alexandre , Fuller Megan , Chang Linda , Wong Fred , Paliouras Grigorios , Shaw Rebecca , Kyle Alastair H. , Umlandt Patricia , Baker Jennifer H.E. , Diaz Erika , Tong Jade , Minchinton Andrew I. , Karsan Aly
Published: March 2023

PDF file - 3357K, Figure S1. DnMAML-mediated EC-specific Notch blockade inhibits larger vessel function. Figure S2. Flow cytometry analysis of PDGFRβ in LLC-VEGFA tumors of control and double Tg. Figure S3. NO production in the microvasculature of LLC-VEGFA tumors in response to EC-specific Notch inhibition. Figure S4 Effect of the NO-independent soluble guanylyl cyclase agonist BAY41-2272 on tumor growth in EC-specific Notch-inhibited mice. Figure S3. NO production in the microvasculature of LLC-VEGFA tumors in response to EC-specific Notch inhibition. Figure S5. dnMAML-mediated EC Notch blockade inhibits growth, functional blood vessels and eNOS activation of B16F10-VEGFA tumors. Figure S6. Expression analysis of vasodilatory genes Nts and Adm in response to EC-specific Notch inhibition in tumors. Table S1. RT-PCR analysis of Ace2, Edn2, Agt and Ednra in bulk and sorted endothelial cells (EC) from LLC-VEGFA tumors grown in control and double Tg VE-cadherin-tTA x TetOS-dnMAML-GFP.
Supplementary Tables S1-S3 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Tables S1-S3. Table S1. Patient characteristics Table S2. Distribution of ETBR expression according to patient characteristics Table S3. Univariate and multivariate analysis of clinico-pathological parameters as prognostic factors in ovarian cancer patients
Supplementary Figure S2 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S2. Analysis of ÃŽÂ²-arr1 or ÃŽÂ²-catenin knockdown and effects of ETAR-driven ÃŽÂ²-arr1/ÃŽÂ²-catenin nuclear complexes on ET-1 expression.
Supplementary Figure S1 from Endothelin A Receptor/β-Arrestin Signaling to the Wnt Pathway Renders Ovarian Cancer Cells Resistant to Chemotherapy
Authors: Rosanò Laura , Cianfrocca Roberta , Tocci Piera , Spinella Francesca , Di Castro Valeriana , Caprara Valentina , Semprucci Elisa , Ferrandina Gabriella , Natali Pier Giorgio , Bagnato Anna
Published: March 2023

Supplementary Figure S1. Expression of ETAR and ETBR, and ETAR-driven ÃŽÂ²-arr1/ÃŽÂ²-catenin interaction in chemoresistant EOC cells.
Supplementary Figure 3 from Maintaining Glycogen Synthase Kinase-3 Activity Is Critical for mTOR Kinase Inhibitors to Inhibit Cancer Cell Growth
Authors: Koo Junghui , Yue Ping , Gal Anthony A. , Khuri Fadlo R. , Sun Shi-Yong
Published: March 2023

PDF file - 174KB, INK128 and other TORKinibs decrease cyclin D1 levels.
Supplementary Figure 1 from Cysteine Catabolism: A Novel Metabolic Pathway Contributing to Glioblastoma Growth
Authors: Prabhu Antony , Sarcar Bhaswati , Kahali Soumen , Yuan Zhigang , Johnson Joseph J. , Adam Klaus-Peter , Kensicki Elizabeth , Chinnaiyan Prakash
Published: March 2023

PDF file - 124K, CSA concentrations in GBM. (A) CSA was quantified in GBM using targeted UHPLC-MS/MS and levels were correlated with relative CSA levels obtained from global metabolomic studies. (B) Representative chromatograph of a tissue sample (10.3 ng CSA/mg tissue).
Supplementary Text from Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells
Authors: Wang Bin , Wang Qiang , Wang Zhe , Jiang Jun , Yu Shi-Cang , Ping Yi-Fang , Yang Jing , Xu Sen-Lin , Ye Xian-Zong , Xu Chuan , Yang Lang , Qian Cheng , Wang Ji Ming , Cui You-Hong , Zhang Xia , Bian Xiu-Wu
Published: March 2023

Supplementary Text including Supplementary Methods and Supplementary Figure Legends
Supplementary Figure Legend from FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
Authors: Guillemette Shawna , Branagan Amy , Peng Min , Dhruva Aashana , Schärer Orlando D. , Cantor Sharon B.
Published: March 2023

PDF file - 103K
Supplementary Figure 3 from Metastatic Consequences of Immune Escape from NK Cell Cytotoxicity by Human Breast Cancer Stem Cells
Authors: Wang Bin , Wang Qiang , Wang Zhe , Jiang Jun , Yu Shi-Cang , Ping Yi-Fang , Yang Jing , Xu Sen-Lin , Ye Xian-Zong , Xu Chuan , Yang Lang , Qian Cheng , Wang Ji Ming , Cui You-Hong , Zhang Xia , Bian Xiu-Wu
Published: March 2023

Preferential evasion of BCSCs from NK cell clearance in vivo.
Supplementary Figure 5 from FANCJ Localization by Mismatch Repair Is Vital to Maintain Genomic Integrity after UV Irradiation
Authors: Guillemette Shawna , Branagan Amy , Peng Min , Dhruva Aashana , Schärer Orlando D. , Cantor Sharon B.
Published: March 2023

PDF file - 29K, Supplemental Figure 5. FANCJ precipitates with UV modified PCNA and CPD from chromatin extracts.