bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of Retronasal Flavor Alterations in Smoke-Affected Wines and the Efficacy of Various Inter-Stimulus Rinse Protocols in Clearing Smoke-Related Attributes
Authors: Fryer Jenna A. , Tomasino Elizabeth
Published: April 2022

Wildfires produce smoke, which can then encounter wine grapes, causing the fruit to absorb smoke-related volatile organic compounds. These compounds impact the sensorial profiles of the resulting wines, introducing an uncharacteristic smokey flavor and ashy finish. Since these off-flavor attributes are observed to have longer-lasting perception, a proper inter-stimulus protocol is necessary to ensure an accurate sensory analysis. Previous work has indicated that a 1 g/L pectin rinse with 120 s of separation is effective for clearing the smoke flavor to mitigate potential carryover effects. The purpose of this work was to determine if there was a more efficient rinsing protocol to lessen the time taken between samples. By using wines with various levels of smoke exposure (high, moderate, and none), the efficacy of four different rinse systems were evaluated with a fixed-time-point evaluation system. These results indicate that a 4 g/L glucose solution is more efficient than pectin, requiring only 90 s of separation to clear smoke flavor perception. Additionally, this work identified appropriate references for the retronasal attributes associated with smoke taint in wine. These results can be used to guide a sensory analysis of wildfire-affected wines to ensure effective and accurate results.
Preliminary Studies on the Effects of Oyster Mushroom Spherical Virus China Strain on the Mycelial Growth and Fruiting Body Yield of the Edible Mushroom Pleurotus ostreatus
Authors: Hu Hai-Jing , Wang Jian-Rui , Cheng Xian-Hao , Liu Yu , Zhang Xiao-Yan
Published: April 2022

Oyster mushroom spherical virus (OMSV) is a positive-sense single-stranded RNA mycovirus which is associated with a devastating oyster mushroom die-back disease. However, little is known about its diversity, and the effects of OMSV infection on its fungal host are not well understood. In this study, we determined the nearly complete nucleotide sequence of OMSV isolated from cultivated oyster mushrooms in China. Sequence analysis suggested that the virus represents a new strain of OMSV (referred to here as OMSV-Ch). A GenBank BLAST search of the genomic sequences demonstrated that the OMSV-Ch had the highest identity (74.9%) with the OMSV from Korea (OMSV-Kr). At the amino acid–sequence level, these two strains shared 84.1% identity in putative replication protein (RP) and 94.1% identity in coat protein (CP). Phylogenetic analysis based on RP showed that OMSV-Ch clustered with OMSV-Kr, closely related to Tymoviridae. Phylogenetic analysis based on both the RP and CP showed that OMSV had a distant clade relationship with tymoviruses, marafiviruses, and maculaviruses. We obtained the OMSV-Ch-free Pleurotus ostreatus strain via single hyphal tip cultures combined with high-temperature treatment. Preliminary studies indicate that OMSV-Ch can significantly inhibit mycelial growth, cause malformations of the fruiting bodies, and reduce the yield of P. ostreatus. Co-cultivation resulted in horizontal transmission of the OMSV-Ch to a virus-cured strain. The findings of our study contribute to the prevention and control of mycoviral diseases in the future.
Toxic Effects of Endocrine Disruptor Exposure on Collagen-Induced Arthritis
Authors: D’Amico Ramona , Gugliandolo Enrico , Cordaro Marika , Fusco Roberta , Genovese Tiziana , Peritore Alessio Filippo , Crupi Rosalia , Interdonato Livia , Di Paola Davide , Cuzzocrea Salvatore , Impellizzeri Daniela , Siracusa Rosalba , Di Paola Rosanna
Published: April 2022

Endocrine disruptors (EDs) are chemical substances capable of affecting endocrine system functioning and interfering with organ morphogenesis and physiological functions. The development and regeneration of bone tissues have a complex hormonal regulation, and therefore, bone tissue cells can be considered potential targets for endocrine disruptors. In that regard, the aim of this research was to investigate the impact of ED exposure on the inflammatory response and oxidative stress in an experimental model of collagen-induced arthritis (CIA). Arthritis was induced by an emulsion of type II collagen (CII) and complete Freund’s adjuvant, which was administered intradermally on days 0 and 21. Mice from day 21 to day 35 received the following EDs by oral gavage: cypermethrin (CP), diethyl phthalate (DEP), vinclozolin (VCZ), 17α-ethinylestradiol (EE), perfluorooctanesulfonic acid (PFOS) and atrazine (ATR). ED exposure caused worsening of clinical signs (erythema and edema in the hind paws), histological and radiographic changes, as well as behavioral deficits, induced by CII injections. Furthermore, ED exposure significantly increased the degree of inflammation and oxidative damage induced by arthritis; this upregulation was more evident after exposure to ATR than to other EDs. The results from our study suggest that exposure to EDs may play a deleterious role in the progression of RA; therefore, exposure to EDs should be limited.
Strength Performance of the Connection between Brick and SPF Lumber
Authors: Ganbaatar Ariunaa , Mori Takuro , Inoue Ryo , Danzandorj Sunjidmaa
Published: April 2022

There are many ways to strengthen an unreinforced brick masonry wall. One of the strengthening methods applies timber, which is a lightweight and easy installation. The connection between the timber and the brick masonry wall plays an important role. In this study, the experimental and theoretical methods were investigated, and the pullout and shear strengths of the chemical anchor were employed as the connection between clay brick and SPF (spruce, pine, fir) lumber. Three bolt diameters (ø8, ø10, ø12 mm) were utilized in nine pullout tests and two types of eighteen shear tests. Four types of prediction models estimated the pullout strength of the chemical anchor. The European Yield Theory (EYT) expected the shear strength of the chemical anchor, involving six failure modes. The results of all experiments were discussed as failure mode, strength, and stiffness under monotonic load. Finally, the effective result of this study highlights A12 specimens using ø12 mm bolt and employing the epoxy resin in brick and lumber. The maximum pullout load of A12 specimens is 12.1 kN, and the yield shear load is 11.2 kN.
Clinical Phenotype and Management of Severe Neurotoxicity Observed in Patients with Neuroblastoma Treated with Dinutuximab Beta in Clinical Trials
Authors: Wieczorek Aleksandra , Manzitti Carla , Garaventa Alberto , Gray Juliet , Papadakis Vassilios , Valteau-Couanet Dominique , Zachwieja Katarzyna , Poetschger Ulrike , Pribill Ingrid , Fiedler Stefan , Ladenstein Ruth , Lode Holger N.
Published: April 2022

Neurotoxicity is an off-tumour, on-target side effect of GD2-directed immunotherapy with monoclonal antibodies. Here, we report the frequency, management and outcome of patients enrolled in two prospective clinical trials who experienced severe neurotoxicity during immunotherapy with the anti-GD2 antibody dinutuximab beta (DB) administered as short-term infusion (HR-NBL1/SIOPEN study, randomisation R2, EudraCT 2006-001489-17) or as long-term infusion (HR-NBL1/SIOPEN study, randomisation R4, EudraCT 2006-001489-17 and LTI/SIOPEN study, EudraCT 2009-018077-31), either alone or with subcutaneous interleukin-2 (scIL-2). The total number of patients included in this analysis was 1102. Overall, 44/1102 patients (4.0%) experienced Grade 3/4 neurotoxicities (HR-NBL1 R2, 21/406; HR-NBL1 R4, 8/408; LTI study, 15/288), including 27 patients with severe neurotoxicities (2.5%). Events occurred predominantly in patients receiving combined treatment with DB and scIL-2. Neurotoxicity was treated using dexamethasone, prednisolone, intravenous immunoglobulins and, in two patients, plasmapheresis, which was highly effective. While neurological recovery was observed in 16 of 21 patients with severe neurotoxicities, 5/1102 (0.45%) patients experienced persistent and severe neurological deficits. In conclusion, severe neurotoxicity is most commonly observed in patients receiving DB with scIL-2. Considering the lack of clinical benefit for IL-2 in clinical trials so far, the administration of IL-2 alongside DB is not recommended.
Fast Terminal Synergetic Control of PMVG-Based Wind Energy Conversion System for Enhancing the Power Extraction Efficiency
Authors: Mayilsamy Ganesh , Natesan Balasubramani , Joo Young Hoon , Lee Seong Ryong
Published: April 2022

This study presents a fast terminal synergetic control (FTSC) scheme to investigate the nonlinear control problem of permanent magnet vernier generator (PMVG)-based variable-speed wind energy conversion systems (WECSs). In wind turbines, better speed tracking and fast dynamic behavior is required to achieve the maximum power extraction. To do this, the FTSC method is firstly proposed to improve the dynamic performance of tracking the speedby, addressing the turbulent wind and uncertainties in the PMVG system, which improves the wind energy extraction efficiency and alleviates mechanical stress over the turbine. Next, the closed-loop FTSC with a macro variable and novel reaching law is presented to enhance the convergence of the speed error signal when it is far from equilibrium in finite time. At this time, the controller’s output is a zero chattering generator torque reference that can operate the system in both below- and above-rated wind conditions, in addition to pitch control. Then, the proposed control method is verified for its effectiveness in energy capture through numerical simulation and experimental verification of a 5 kW direct drive PMVG-based WECS. Finally, comparative results confirm the better performance of the proposed system under transients than other controllers considered in this analysis.
Synthetic Theft Attacks and Long Short Term Memory-Based Preprocessing for Electricity Theft Detection Using Gated Recurrent Unit
Authors: Pamir  , Javaid Nadeem , Javaid Saher , Asif Muhammad , Javed Muhammad Umar , Yahaya Adamu Sani , Aslam Sheraz
Published: April 2022

Electricity theft is one of the challenging problems in smart grids. The power utilities around the globe face huge economic loss due to ET. The traditional electricity theft detection (ETD) models confront several challenges, such as highly imbalance distribution of electricity consumption data, curse of dimensionality and inevitable effects of non-malicious factors. To cope with the aforementioned concerns, this paper presents a novel ETD strategy for smart grids based on theft attacks, long short-term memory (LSTM) and gated recurrent unit (GRU) called TLGRU. It includes three subunits: (1) synthetic theft attacks based data balancing, (2) LSTM based feature extraction, and (3) GRU based theft classification. GRU is used for drift identification. It stores and extracts the long-term dependency in the power consumption data. It is beneficial for drift identification. In this way, a minimum false positive rate (FPR) is obtained. Moreover, dropout regularization and Adam optimizer are added in GRU for tackling overfitting and trapping model in the local minima, respectively. The proposed TLGRU model uses the realistic EC profiles of the Chinese power utility state grid corporation of China for analysis and to solve the ETD problem. From the simulation results, it is exhibited that 1% FPR, 97.96% precision, 91.56% accuracy, and 91.68% area under curve for ETD are obtained by the proposed model. The proposed model outperforms the existing models in terms of ETD.
Optimization of Solar/Fuel Cell Hybrid Energy System Using the Combinatorial Dynamic Encoding Algorithm for Searches (cDEAS)
Authors: Kim Jong-Wook , Ahn Heungju , Seo Hyeon Cheol , Lee Sang Cheol
Published: April 2022

This study proposes a computational design method for determining a hybrid power system’s sizing and ratio values that combines the national electric, solar cell, and fuel cell power sources. The inequality constraints associated with the ranges of power storage exchange and the stored energy are reflected as penalty functions in the overall cost function to be minimized. Using the energy hub model and the actual data for the solar cell power and the load of the residential sector in one Korean city for one hundred days, we optimize the ratio of fuel cell energy and solar cell energy to 0.46:0.54 through our proposed approach. We achieve an average cost-reduction effect of 19.35% compared to the cases in which the fuel-cell energy ratio is set from 0.1 to 0.9 in 0.1 steps. To optimize the sizing and the ratio of fuel-cell energy in the hybrid power system, we propose the modified version of the univariate dynamic encoding algorithm for searches (uDEAS) as a novel optimization method. The proposed novel approaches can be applied directly to any place to optimize an energy hub system model comprising three power sources, i.e., solar power, fuel cell, and power utility.
Dynamics and Kinematics of the EUV Wave Event on 6 May 2019
Authors: Chandra Ramesh , Chen P. F. , Devi Pooja , Joshi Reetika , Ni Y. W.
Published: April 2022

We present here the kinematics of the EUV wave associated with a GOES M1.0-class solar flare, which originates in NOAA AR 12740. The event is thoroughly observed with Atmospheric Imaging Assembly (AIA) onboard Solar Dynamics Observatory (SDO) with high spatio-temporal resolutions. This event displays many features of EUV waves, which are very decisive for the understanding of the nature of EUV waves. These features include: a fast-mode wave, a pseudo wave, a slow-mode wave and stationary fronts, probably due to mode conversion. One fast-mode wave also propagates towards the coronal hole situated close to the north pole and the wave speed does not change when it encounters the coronal hole. We intend to provide self-consistent interpretations for all these different features.
Analysis of Structural Characteristics and Psychometric Properties of the SarQoL® Questionnaire in Different Languages: A Systematic Review
Authors: Martínez-Fernández María Visitación , Sandoval-Hernández Irene , Galán-Mercant Alejandro , Gonzalez-Sanchez Manuel , Martínez-Cal Jesús , Molina-Torres Guadalupe
Published: April 2022

Background: Sarcopenia is the gradual and global loss of muscle and its functions. Primary sarcopenia is associated with the typical changes of advanced aging and affects approximately 5–10% of the population. The Sarcopenia and Quality of Life (SarQoL®) questionnaire is composed of 55 items, 22 questions, and is organized into seven domains of quality of life. The main objective of this systematic review was to analyze the structural characteristics and psychometric properties of it, as well as to classify its measurement properties, its methodological quality, and the criteria as good measurement properties of the adaptations and validations made on the SarQoL® questionnaire in different languages. Methods: A systematic review was carried out in the PUBMED, Web of Science, Cinahl, LatinIndex, and SCOPUS databases. The keywords used were: “SarQoL”, “assessment”, “sarcopenia”, “geriatric”, “PROM”, “quality of life”, and “questionnaire”, using the Boolean operator “AND”. All articles published up to 15 January 2022 were considered. Methodological quality and psychometric properties were assessed based on the COSMIN guidelines and the guidelines and general recommendations of PRISMA. Documents published in languages other than English were excluded, as well as versions of the SarQoL® published in the form abstracts for conferences when the full text was not available. Results: A total of 133 articles were identified, 14 of which were included. The evaluated questionnaires and the structural characteristics and psychometric properties of each of them were collected. Conclusion: The different cross-cultural versions of the questionnaire showed good basic structural and psychometric characteristics for the evaluation of patients with sarcopenia.
Effects of SARS-CoV-2 Inflammation on Selected Organ Systems of the Human Body
Authors: Kopańska Marta , Barnaś Edyta , Błajda Joanna , Kuduk Barbara , Łagowska Anna , Banaś-Ząbczyk Agnieszka
Published: April 2022

Introduction and purpose of the study: SARS-CoV-2 virus does not only affect the respiratory system. It may cause damage to many organ systems with long-term effects. The latest scientific reports inform that this virus leaves a long-term trace in the nervous, circulatory, respiratory, urinary and reproductive systems. It manifests itself in disturbances in the functioning of the organs of these systems, causing serious health problems. The aim of the study was to review the latest research into the long-term effects of COVID-19 and determine how common these symptoms are and who is most at risk. Based on a literature review using the electronic scientific databases of PubMed and Web of Science on the long-term effects of SARS-CoV-2 infection, 88 studies were included in the analysis. The information contained in the analyzed literature shows that the SARS-CoV-2 virus can cause multi-organ damage, causing a number of long-term negative health complications. Conclusions: There is evidence that the virus can cause long-term complications lasting more than six months. They mainly concern disturbances in the functioning of the nervous, circulatory and respiratory systems. However, these studies are small or short-lasting, and many are speculative.
Time Course of Changes in the Neurovascular Unit after Hypoxic-Ischemic Injury in Neonatal Rats
Authors: Hatayama Kazuki , Riddick Sydney , Awa Fares , Chen Xiaodi , Virgintino Daniela , Stonestreet Barbara
Published: April 2022

Exposure to hypoxic-ischemic (HI) insults in newborns can predispose them to severe neurological sequela. The mechanisms underlying HI-related brain injury have not been completely elucidated. The neurovascular unit (NVU) is a composite of structures that protect the brain from the influx of detrimental molecules. Changes in the NVU after HI are important because they could reveal endogenous neuroprotective pathways in the cerebral microvasculature. Furthermore, the time course of changes in the NVU after exposure to HI in the newborn remains to be determined. In this study, we examined the effects of severe HI on the time course of changes in the NVU in neonatal rats. Brains were collected from rats exposed to right carotid artery ligation and 2 h of hypoxia on postnatal day 7 with recovery for 6 or 48 h after exposure to sham treatment (Sham) or HI. The right HI and left hypoxic alone sides of the brains were examined by quantitative immunohistochemistry for vascular density (laminin), pericyte vascular coverage (PDGFRβ), astrocyte vascular coverage (GFAP), and claudin-5 expression in the microvasculature of the cerebral cortex, white matter, and hippocampus. HI-related brain injury in neonatal rats was associated with increases in vascular density in the cortex and hippocampus 48 h after HI as well as neurovascular remodeling, including loss of pericyte coverage in the cortex and increases in claudin-5 in the hippocampus 6 h after HI. Astrocyte coverage was not affected by HI injury. The time course of the responses in the different components of the NVU varied after exposure to HI. There were also differential regional responses in the elements of the NVU in response to HI and hypoxia alone.
Contractile Behavior of Right Atrial Myocardium of Healthy Rats and Rats with the Experimental Model of Pulmonary Hypertension
Authors: Lookin Oleg , Mukhlynina Elena , Protsenko Yuri
Published: April 2022

There is a lack of data about the contractile behavior of the right atrial myocardium in chronic pulmonary heart disease. We thoroughly characterized the contractility and Ca transient of isolated right atrial strips of healthy rats (CONT) and rats with the experimental model of monocrotaline-induced pulmonary hypertension (MCT) in steady state at different preloads (isometric force-length), during slow force response to stretch (SFR), and during post-rest potentiation after a period of absence of electrical stimulation (PRP). The preload-dependent changes in the isometric twitch and Ca transient did not differ between CONT and MCT rats while the kinetics of the twitch and Ca transient were noticeably slowed down in the MCT rats. The magnitude of SFR was significantly elevated in the MCT right atrial strips and this was accompanied by the significantly higher elevation of the Ca transient relative amplitude at the end of SFR. The slow changes in the contractility and Ca transient in the PRP protocol did not differ between CONT and MCT. In conclusion, the alterations in the contractility and Ca transient of the right atrial myocardium of monocrotaline-treated rats with pulmonary hypertension mostly concern the elevation in SFR. We hypothesize that this positive inotropic effect in the atrial myocardium may (partly) compensate the systolic deficiency of the right ventricular failing myocardium.
GelMA Hydrogel Reinforced with 3D Printed PEGT/PBT Scaffolds for Supporting Epigenetically-Activated Human Bone Marrow Stromal Cells for Bone Repair
Authors: Man Kenny , Alcala Cesar , Mekhileri Naveen V. , Lim Khoon S. , Jiang Lin-Hua , Woodfield Tim B. F. , Yang Xuebin B.
Published: April 2022

Epigenetic approaches using the histone deacetylase 2 and 3 inhibitor-MI192 have been reported to accelerate stem cells to form mineralised tissues. Gelatine methacryloyl (GelMA) hydrogels provide a favourable microenvironment to facilitate cell delivery and support tissue formation. However, their application for bone repair is limited due to their low mechanical strength. This study aimed to investigate a GelMA hydrogel reinforced with a 3D printed scaffold to support MI192-induced human bone marrow stromal cells (hBMSCs) for bone formation. Cell culture: The GelMA (5 wt%) hydrogel supported the proliferation of MI192-pre-treated hBMSCs. MI192-pre-treated hBMSCs within the GelMA in osteogenic culture significantly increased alkaline phosphatase activity (p ≤ 0.001) compared to control. Histology: The MI192-pre-treated group enhanced osteoblast-related extracellular matrix deposition and mineralisation (p ≤ 0.001) compared to control. Mechanical testing: GelMA hydrogels reinforced with 3D printed poly(ethylene glycol)-terephthalate/poly(butylene terephthalate) (PEGT/PBT) scaffolds exhibited a 1000-fold increase in the compressive modulus compared to the GelMA alone. MI192-pre-treated hBMSCs within the GelMA–PEGT/PBT constructs significantly enhanced extracellular matrix collagen production and mineralisation compared to control (p ≤ 0.001). These findings demonstrate that the GelMA–PEGT/PBT construct provides enhanced mechanical strength and facilitates the delivery of epigenetically-activated MSCs for bone augmentation strategies.
Effects of Drought on the Growth of Lespedeza davurica through the Alteration of Soil Microbial Communities and Nutrient Availability
Authors: Duan Dongdong , Jiang Feifei , Lin Weihu , Tian Zhen , Wu Nana , Feng Xiaoxuan , Chen Tao , Nan Zhibiao
Published: April 2022

Lespedeza davurica (Laxm.) is highly important for reducing soil erosion and maintaining the distinctive natural scenery of semiarid grasslands in northwest China. In this study, a pot experiment was conducted to investigate the effects of drought (20% water-holding capacity) on biomass and its allocation, root characteristics, plant hormones, and soil microbial communities and nutrients after L. davurica was grown in a greenhouse. Drought reduced the total biomass of L. davurica but increased the root:shoot biomass ratio. In addition, drought altered the composition and structure of microbial communities by limiting the mobility of nutrients in non-rhizosphere soils. In particular, drought increased the relative abundances of Basidiomycota, Acidobacteria, Actinobacteria, Coprinellus, Humicola and Rubrobacter, which were closely positively related to the soil organic carbon, pH, available phosphorus, ammonia nitrogen (N) and nitrate N under drought conditions. Furthermore, soil fungi could play a more potentially significant role than that of bacteria in the response of L. davurica to drought. Consequently, our study uncovered the effects of drought on the growth of L. davurica by altering soil microbial communities and/or soil nutrients, thus providing new insights for forage production and natural grassland restoration on the Loess Plateau of China.
Barriers Affecting Women’s Access to Urban Green Spaces during the COVID-19 Pandemic
Authors: Mayen Huerta Carolina , Utomo Ariane
Published: April 2022

During the COVID-19 pandemic, urban green spaces (UGS) have gained relevance as a resilience tool that can sustain or increase well-being and public health in cities. However, several cities in Latin America have seen a decrease in their UGS use rates during the health emergency, particularly among vulnerable groups such as women. Using Mexico City as a case study, this research examines the main barriers affecting women’s access to UGS during the COVID-19 pandemic in Latin America. We applied a sequential mixed-methods approach in which the results of a survey distributed via social media in June 2020 to women aged 18 and older were used to develop semi-structured interviews with 12 women during October 2020. One year later, in November 2021, the continuity of the themes was evaluated through focus groups with the same group of women who participated in the interviews. Our results suggest that (1) prohibiting access to some UGS during the first months of the pandemic negatively impacted UGS access for women in marginalized neighborhoods; (2) for women, the concept of UGS quality and safety are intertwined, including the security level of the surrounding streets; and (3) women who live in socially cohesive neighborhoods indicated using UGS to a greater extent. Our findings highlight that while design interventions can affect women’s willingness to use UGS by improving their perceived safety and comfort, they remain insufficient to fully achieve equity in access to UGS.
Agroecological Efficiency Evaluation Based on Multi-Source Remote Sensing Data in a Typical County of the Tibetan Plateau
Authors: Wang Qizhi , Gao Maofang , Zhang Huijie
Published: April 2022

Evaluating agricultural ecology can help us to understand regional environmental status and contribute to the sustainable development of agricultural ecosystems. Furthermore, the results of eco-environmental assessment can provide data support for policy-making and agricultural production. The application of multi-source remote-sensing technology has the advantages of being fast, accurate and wide ranging. It can reveal the status of regional ecological environments, and is of great significance to monitoring their quality. In this paper, an agroecological efficiency evaluation model was constructed by combining remote sensing data and ecological index (EI). Multi-source remote-sensing data were used to obtain the evaluation index. Indicators collected from satellites, such as biological richness, vegetation cover, water network density, land stress, and pollution load, were used to quantitatively evaluate the agroecological efficiency of Rangtang County in the Tibetan Plateau. The results showed that the EI of Rangtang County increased from 61.77 to 65.10 during 2000–2020, which means that the eco-environmental quality of this area was good, and it has shown an obviously improving trend over the past 20 years. Rangtang County has converted more than 30 km²of grassland into woodland over the past 20 years. Climate change and human activities have had combined effects on the ecological environment of this area. The change in ecological environment quality is greatly affected by human disturbance. Policymakers should continue setting up nature reserves and should implement the policy of returning farmland to forests. Unreasonable grazing and rational allocation of land resources are still critical points of concern for future ecological environment construction. EI, combined with remote sensing and statistical data, is proven to be able to reasonably represent changes in ecological environment in Rangtang County, thus providing more possibilities for ecological evaluation on the Tibetan Plateau, and even the whole world.
Effects of Heat Reflux on Two-Phase Flow Characteristics in a Capillary of the ADN-Based Thruster
Authors: Yan Zhuan , Liu Xuhui , Yu Yusong , Cao Jie , Liu Xiaodan , Zhang Shurui
Published: April 2022

During the working process of the ADN-based thruster, continuously, heat generated by the chemical reaction in the combustion chamber will transfer along the upstream capillary, the propellant in the capillary continuously absorbs heat under the effect of heat transfer from the wall and undergoes a phase change when the saturation temperature is reached. In this study, effects of the downstream heating temperature (623 K to 923 K) on mass flow rate and pressure change in the capillary were investigated based on the established test platform. Simultaneously, the VOF (volume of fraction) model, and the Lee phase transition model coupled with the Navier–Stokes method was utilized to simulate the spatial distribution of the gas-liquid propellant in the capillary. The results show that the ADN-based propellant firstly formed bubbles on the inner wall surface near the exit of the capillary, and these vapor bubbles moved and grew upstream along the capillary. Due to the cooling effect of the ADN-based propellant inflow, the temperature distribution of the front chamber and capillary gradually reached equilibrium. Bubbles were constantly generated in the capillary, and as the heat reflux intensified, the total volume of bubbles in the capillary continued increasing. Single-phase flow, annular flow, wave flow, and segment plug flow appeared sequentially along the axial direction of the capillary, and the proportion of gas phase volume fraction at the capillary outlet section gradually increased.
Rock Mass and Pore Fluid Response in Deep Mining: A Field Monitoring Study at Inclined Longwalls
Authors: Qu Qingdong , Guo Hua , Yuan Liang , Shen Baotang , Yu Guofeng , Qin Johnny
Published: April 2022

The dynamics of stress, deformation and pore pressure in the surrounding strata of underground mines are of fundamental importance to groundwater and gas emission management. Compared to numerous studies on the overlying strata, there are significantly fewer investigations concerning the underlying strata, particularly involving large-scale field monitoring. This paper presents a comprehensive field monitoring study conducted at two longwall panels with a depth of around 800 m and an inclination angle of 21°. The monitoring program focused on the floor strata within 50 m below the mining operation, but also covered the roof strata close to the longwall roadway. The purpose was to characterise the favourable zone for gas extraction from the floor coal seams. A combination of stressmeters, extensometers and piezometers were deployed and installed underground. The monitored results demonstrated that the stress change exhibited a three-stage variation—increase, decrease and recovery—during which the strata deformed and the pore pressure changed correspondingly. Strata expansion in the floor occurred primarily in the region 0–35 m behind the longwall face and vertically to at least 42 m below. Some predictive methods of the depth of the failure zone used in shallow mines were analysed to determine if they were still applicable for mining at a depth of around 800 m.
Effect of Aqueous Cinnamon Extract on the Postprandial Glycemia Levels in Patients with Type 2 Diabetes Mellitus: A Randomized Controlled Trial
Authors: Rachid Ana Paula , Moncada Margarida , Mesquita Maria Fernanda de , Brito José , Bernardo Maria Alexandra , Silva Maria Leonor
Published: April 2022

Cinnamon is a spice used in traditional cuisine that has been investigated due to hypoglycemic properties. The objective of this study was to investigate the effect of aqueous cinnamon extract on postprandial glycemia levels in type 2 diabetes mellitus (DM2) adults. This clinical trial enrolled 36 adults with DM2, randomly allocated in two groups: the control group (n = 18) took only an oral glucose tolerance test (OGTT) and the intervention group (n = 18) took OGTT immediately followed by aqueous cinnamon extract (6 g/100 mL) ingestion. Blood glucose levels were measured on fasting and after 30, 60, 90 and 120 min in both groups. The chemical analysis of the aqueous cinnamon extract included total phenols content determination and antioxidant activity assessment through FRAP and DPPH methods. The data reveal that aqueous cinnamon extract ingestion did not show a significant difference in the incremental area under the curve (p = 0.834), maximum glucose concentration (p = 0.527) and glucose concentration variation (p = 0.873) compared with the control group. Cinnamon extract possess a total phenol content of 1554.9 mg/L gallic acid equivalent and a strong antioxidant capacity, revealed by the DPPH (5125.0 µmol Trolox/L) and FRAP (3658.8 µmol Trolox/L) tests. Aqueous cinnamon extract did not significantly influence postprandial glucose response in diabetic patients during an OGTT.
Nutrition Education Programs for Adults with Neurological Diseases Are Lacking: A Scoping Review
Authors: Russell Rebecca D. , Black Lucinda J. , Begley Andrea
Published: April 2022

The nutrition recommendation for most common neurological diseases is to follow national dietary guidelines. This is to mitigate malnutrition, reduce the risk of diet-related diseases, and to help manage some common symptoms, including constipation. Nutrition education programs can support people in adhering to guidelines; hence the aim of this scoping review was to explore what programs have been implemented for adults with neurological diseases. We conducted this review according to a published a priori protocol. From 2555 articles screened, 13 were included (dementia n = 6; multiple sclerosis n = 4; stroke survivors n = 2; Parkinson’s n = 1). There were no programs for epilepsy, Huntington’s, and motor neurone disease. Program duration and number of sessions varied widely; however, weekly delivery was most common. Just over half were delivered by dietitians. Most did not report using a behavior change theory. Commonly used behavior change techniques were instruction on how to perform a behavior, credible source, and behavioral practice/rehearsal. Evidence of nutrition education programs for adults with neurological diseases is lacking. Of those that are published, many do not meet best practice principles for nutrition education regarding delivery, educator characteristics, and evaluation. More programs aligning with best practice principles are needed to assess characteristics that lead to behavior change.
Towards Selective Binding to the GLUT5 Transporter: Synthesis, Molecular Dynamics and In Vitro Evaluation of Novel C-3-Modified 2,5-Anhydro-D-mannitol Analogs
Authors: Rana Natasha , Aziz Marwa A. , Oraby Ahmed K. , Wuest Melinda , Dufour Jennifer , Abouzid Khaled A. M. , Wuest Frank , West F. G.
Published: April 2022

Deregulation and changes in energy metabolism are emergent and important biomarkers of cancer cells. The uptake of hexoses in cancer cells is mediated by a family of facilitative hexose membrane-transporter proteins known as Glucose Transporters (GLUTs). In the clinic, numerous breast cancers do not show elevated glucose metabolism (which is mediated mainly through the GLUT1 transporter) and may use fructose as an alternative energy source. The principal fructose transporter in most cancer cells is GLUT5, and its mRNA was shown to be elevated in human breast cancer. This offers an alternative strategy for early detection using fructose analogs. In order to selectively scout GLUT5 binding-pocket requirements, we designed, synthesized and screened a new class of fructose mimics based upon the 2,5-anhydromannitol scaffold. Several of these compounds display low millimolar IC50 values against the known high-affinity 18F-labeled fructose-based probe 6-deoxy-6-fluoro-D-fructose (6-FDF) in murine EMT6 breast cancer cells. In addition, this work used molecular docking and molecular dynamics simulations (MD) with previously reported GLUT5 structures to gain better insight into hexose–GLUT interactions with selected ligands governing their preference for GLUT5 compared to other GLUTs. The improved inhibition of these compounds, and the refined model for their binding, set the stage for the development of high-affinity molecular imaging probes targeting cancers that express the GLUT5 biomarker.
Sequential Application of Column Leaching and Plant Uptake Tests to Assess the Effect of Various Commercial Amendments on Cu Immobilization in Ultra-High Cu-Contaminated Soil
Authors: Quoc Tuan-Nguyen , Jung Myung-Chae
Published: April 2022

The presence of copper (Cu)-contaminated soil has increased recently due to agricultural and industrial activities. Immobilization techniques using soil amendments have attracted significant research because of their cost-effectiveness, eco-friendliness, and community acceptance. This study used various commercial amendments, including magnetite (M), talc (T), activated carbon (AC), and cornstarch (CS), to immobilize Cu in soil contaminated by acidic waste materials with Cu in Korea (9546 ± 5 mg/kg). To evaluate the immobilizing effect of these amendments, this study applied a sequential process of column leaching and plant uptake tests to observe the ability of Cu to remain in soil with and without amendments through the Cu removal rate. The amendments were characterized by SEM, XRD, and specific surface area and applied to the soil at a rate of 2% (w/w). The first stage of evaluation, i.e., the column leaching test, was conducted by continuously pumping distilled water (DW) for 28 days, and the second stage of evaluation, i.e., the plant uptake test, was started immediately after by planting 10-day-old lettuce seedlings for 28 days. The experimental results showed that all of the amendments had a significant effect on Cu immobilization Cu in soil (p < 0.05), and the T treatment showed the highest efficiency in Cu immobilization, with only 47.0% Cu loss compared to 73.5% in the control soil when assessed by sequential column leaching and plant uptake tests. In conclusion, this study provides an effective assessment method to evaluate the effect of amendments on Cu immobilization in soil, as well as providing feasible options to immobilize Cu using commercial amendments.
Young people who have fallen through the mental health transition gap: a qualitative study on primary care support
Authors: Appleton Rebecca , Loew Joelle , Mughal Faraz
Published: April 2022

Background

Owing to poor continuity of care between child and adult mental health services, young people are often discharged to their GP when they reach the upper boundary of child and adolescent mental health services (CAMHS). This handover is poorly managed, and GPs can struggle to support young people without input from specialist services. Little is known about young people’s experiences of accessing mental health support from their GP after leaving CAMHS.

Aim

To explore the experiences and perspectives of young people and the parents/carers of young people receiving primary care support after CAMHS and to identify barriers and facilitators to accessing primary care.

Design and setting

Qualitative study with young people and parents in two English counties: London and West Midlands.

Method

Narrative interviews were conducted with 14 young people and 13 parents who had experienced poor continuity of care after reaching CAMHS transition boundary. Data were analysed using reflexive thematic analysis.

Results

Three themes were identified: unmet mental health needs, disjointed care, and taking responsibility for the young person’s mental health care. Barriers included the perception that GPs couldn’t prescribe certain medication, anxiety caused by the general practice environment, and having to move to a new practice at university. Young people’s positive experiences were more likely to include having a long-term relationship with their GP and finding that their GP made time to understand their needs and experiences.

Conclusion

GPs could help to meet the unmet needs of young people unable to access specialist mental health services after leaving CAMHS. There is a need for comprehensive handover of care from CAMHS to GPs, which could include a joint meeting with the young person and a member of the CAMHS team. Future research should focus on interventions which improve continuity of care for young people after leaving CAMHS, and collaborative working across community mental health services.
Non-speculum clinician-taken samples for human papillomavirus testing: a cross-sectional study in older women
Authors: Landy Rebecca , Hollingworth Tony , Waller Jo , Marlow Laura AV , Rigney Jane , Round Thomas , Sasieni Peter D , Lim Anita WW
Published: April 2022

Background

Cervical cancer incidence and mortality are high in women aged ≥65 years, despite the disease being preventable by screening. Speculum-based screening can become more uncomfortable after the menopause.

Aim

To examine test performance and acceptability of human papillomavirus (HPV) testing on clinician-collected vaginal samples without a speculum (non-speculum).

Design and setting

Cross-sectional study in 11 GP practices and four colposcopy clinics in London, UK, between August 2017 and January 2019.

Method

Non-speculum and conventional (speculum) samples were collected from women aged ≥50 years attending for a colposcopy (following a speculum HPV-positive screening result) or women aged ≥35 years (with confirmed cervical intraepithelial neoplasia (CIN) 2+), and women aged 50–64 years attending routine screening. Sensitivity to CIN2+ was assessed among women with confirmed CIN2+ (colposcopy). Specificity to HPV relative to speculum sampling and overall concordance was assessed among women with negative cytology (routine screening).

Results

The sensitivity of non-speculum sampling for detecting CIN2+ was 83.3% (95% confidence interval [CI] = 60.8 to 94.2) (n = 15/18). There was complete concordance among women with positive CIN2+ who had a speculum sample ≤91 days prior to the non-speculum sample (n = 12). Among 204 women with negative cytology, the specificity to HPV was 96.4% (95% CI = 92.7 to 98.5), with 96.6% concordant results (κ 72.4%). Seventy-one percent (n = 120/170) of women preferred a non-speculum sample for their next screen.

Conclusion

HPV testing on non-speculum clinician-taken samples is a viable approach that warrants further exploration in larger studies. Overall test performance was broadly comparable with that of self-sampling.
RESISTANCE OF SHORT CONCRETE ELEMENTS TO OFF-CENTER COMPRESSION WITH LARGE ECCENTRITIES
Authors: Donchenko Oleg
Published: April 2022

The paper considers the methodology of calculation of short concrete elements under eccentric compression with large eccentricities. The analysis of normative methods of calculation of eccentrically-compressed elements has been carried out and the reasons of discrepancy of calculated values with experimental ones for concretes of class B15-B60 have been established. The equations of equilibrium conditions, deformations, physical laws and geometrical relations developed by the author on the basis of the results analysis of numerous experimental laboratory researches of concrete and reinforced concrete elements under central and eccentric compression and bending are presented. The numerical investigation of the bearing capacity of eccentrically compressed elements with large eccentricities (from 0.167 to 0.45h) and of concrete strength from B15 to B60 MPa has been made in comparison with the data of other researches and with the normative procedure. The results showed that the bearing capacity of the majority of calculated elements compared to the normative method turned out to be 20-25 % higher, and transverse stiffness by 30-35 %. It has been established that the developed solution gives qualitatively more correct and quantitatively more exact results in the whole range of eccentricities and concrete strength than those obtained by means of normative literature, realizing a differentiated approach to different concrete strengths. The analytical dependences of the developed method, obtained in closed form, can be recommended for use in design practice.
Pretransplant Dialysis and Preemptive Transplant in Living Donor Kidney Recipients
Authors: Lai Mason , Gao Ying , Tavakol Mehdi , Freise Chris , Lee Brian K. , Park Meyeon
Published: April 2022

Key Points

Peritoneal dialysis and multimodal dialysis were the most prevalent access modalities among living donor transplant recipients.

Living donor transplant recipients may benefit from a case-by-case approach for dialysis access given shorter time to transplant.

Background

The optimal timing of dialysis access placement in individuals with stage 5 CKD is challenging to estimate. Preemptive living donor kidney transplant (LDKT) is the gold-standard treatment for ESKD due to superior graft survival and mortality, but dialysis initiation is often required. Among LDKT recipients, we sought to determine which clinical characteristics were associated with preemptive transplant. Among non–preemptive LDKT recipients, we sought to determine what dialysis access was used, and their duration of use before receipt of living donor transplant.

Methods

We retrospectively extracted data on 569 LDKT recipients, >18 years old, who were transplanted between January 2014 and July 2019 at UCSF, including dialysis access type (arteriovenous fistula [AVF], arteriovenous graft [AVG], peritoneal dialysis catheter [PD], and venous catheter), duration of dialysis, and clinical characteristics.

Results

Preemptive LDKT recipients constituted 30% of our cohort and were older, more likely to be White, more likely to have ESKD from polycystic kidney disease, and less likely to have ESKD from type 2 diabetes. Of the non–preemptive patients, 26% used AVF, 0.5% used AVG, 32% used peritoneal catheter, 11% used venous catheter, and 31% used more than one access type. Median (IQR) time on dialysis for AVF/AVG use was 1.86 (0.85–3.32) years; for PD catheters, 1.12 (0.55–1.92) years; for venous catheters, 0.66 (0.23–1.69) years; and for multimodal access, 2.15 (1.37–3.72) years.

Conclusions

We characterized the dialysis access landscape in LDKT recipients. Venous catheter and PD were the most popular modality in the first quartile of dialysis, and patients using these modalities had shorter times on dialysis compared with those with an AVF. Venous catheter or PD can be considered a viable bridge therapy in patients with living donor availability given their shorter waitlist times. Earlier referral of patients with living donor prospects might further minimize dialysis need.