bluuebunny/crossref_metadata_2025 huggingface dataset:
Случай на вероятен Синдром на Joubert (мутации в СЕР 120 ген) с атипично протичане
Authors: Божков Антони , Пачева Илияна , Соткова Иглика , Панова Маргарита , Тимова Елена , Тодоров Тихомир
Published: March 2023

Синдромът на Joubert (JS) е рядко автозомно-рецесивно заболяване, което се характеризира с вродена цилиопатия, обуславяща церебро-ретино-ренален фенотип. Клинично се представя с атаксия, хипотония и изоставане в нервно-психическото развитие и един от следните симптоми: неонатални респираторни нарушения, неправилни очни движения, включващи нистагъм и ололомоторна апраксия. „Белег на моларен зъб“ на КТ или МРТ е характерна находка за JS. До момента в литературата са описани повече от 40 гена, които водят до JS.

Представя се случай на момче на 3 години и 8 месеца от нормално протекла бременност, недоносено, страдащо от перинатална асфиксия. Има долихоцефална конфигурация на главата и дискретни дисморфични черти. На 1 г. и 10 м. дебютират епилептичните пристъпи – един при фебрилитет и още четири в афебрилно състояние, някои до епилептичен статус. Момчето е с лека мускулна хипотония, дискоординационен синдром, изоставане в НПР с аутистични прояви и епилепсия. Фамилно обременен с гърчове в детска възраст. Без данни за малформация от проведената МРТ на главен мозък. Метаболитен скрининг установява завишен пролин. След проведено цялостно екзомно секвениране се открива двойна хетерозиготна мутация в CEP 120 гена и вероятно се подозира JS.

Случаят представлява интерес заради рядката причина за вероятен JS, без характерна МРТ находка. Изоставането в НПР с аутистични прояви и епилепсия са водещи и нов клиничен спектър на биалелна мутация в CEP 120 гена би могла да се добави в литературата. Цялостното екзомно секвениране при случаи с изоставане в НПР е важно за установяване на редки генетични диагнози и разширяване на фенотипния спектър на съответното заболяване, а също дава възможност за прогноза и за насочено проследяване на пациента.
La educación superior en la UNESCO: ¿avance o retroceso?
Authors: Didrikssonn Takayanagui Axel
Published: March 2023

En este trabajo se comparan las conferencias regionales y mundiales de la UNESCO sobre educación superior a partir de su organización y realización en América Latina y el Caribe. Se toma como punto de balance la más reciente, la tercera Conferencia Mundial de Educación Superior (CMES), celebrada en Barcelona durante mayo de 2022. La tesis de este trabajo es que el avance conceptual y el nivel de discusión y de enfoque presentado en la conferencia están muy por debajo de lo alcanzado en reuniones precedentes. Esta situación refleja circunstancias poco favorables para la misma UNESCO como espacio constructor de alternativas y de conducción de estrategias que puedan ser referentes en la definición de políticas de Estado de los gobiernos miembros. Del mismo modo, para las comunidades académicas y universitarias, la conferencia dista de reflejar el nivel de discusión alcanzado frente a los cambios que ocurren en los conocimientos, aprendizajes y orientación que deben emprenderse para cumplir con los Objetivos de Desarrollo Sustentable y las recomendaciones formuladas en conferencias anteriores en el seno de la misma UNESCO. La conclusión es que, frente a lo logrado a lo largo de más de dos décadas, la reciente CMES representa un verdadero retroceso, con excepción, como debe comprenderse, de los avances significativos y específicos que se presentaron durante la misma.
Universidade Tecnológica (UT) brasileira: virtudes, desafios e contradições
Authors: De Oliveira Schiefler Filho Marcos Flávio , Souza Maurini
Published: March 2023

Este artigo busca trazer à reflexão a dialética da Universidade Tecnológica Federal do Paraná (UTFPR), única UT brasileira, que se situa no questionamento entre a tendência histórica, que é a oferta de educação voltada à produção e ao imediatismo em um país pautado pela estratificação social, e a obrigação universitária de construir o cidadão emancipado, capaz de refletir e atuar nos diferentes espaços. A instituição derivou de seguidas transformações da Escola de Aprendizes Artífices do Paraná, criada em 1909, a fim de ensinar ofícios a meninos “desfavorecidos da fortuna” para afastá-los da “ociosidade” e do “crime”. Gozando do status de Universidade desde 2005, investe no fazer universitário de uma educação plena; essa dicotomia é trazida à tona por meio de literatura sobre o assunto e as experiências vivenciadas na UTFPR.
PENANAMAN PENGALAMAN LITERASI DINI MENURUT PEMIKIRAN TOMPKINS DAN HOSKISSON
Authors: Florianus Dus Arifian
Published: March 2023

Penanaman Pengalaman Literasi Dini menurut Pemikiran Tompkins dan Hoskisson. pengalaman literasi perlu ditanam sejak dini agar anak dapat menguasai dan mencintai bahasa tulis. namun, penanaman pengalaman literasi dini merupakan gagasan kompleks. oleh karena itu, perlu ada kajian eksplanatif atasnya. dari pemikiran tompkins dan hoskisson tampak bahwa ada tiga poin penting terkait penanaman pengalaman literasi dini, yakni konsep tentang bahasa tulis, munculnya anak dalam membaca, dan munculnya anak dalam menulis. Dalam konsep tentang bahasa tulis, anak membangun persepsi tentang fungsi bahasa tulis, teks, kata, dan alfabet dengan didasarkan pada konteks sekitar. sementara itu, munculnya kemampuan membaca dan menulis pada anak sangat membutuhkan konteks, pendekatan proses dan integratif, dan rancangan ruang belajar literasi yang kondusif.
THE ECONOMETRIC MODEL OF FACTORS AFFECTING POVERTY
Authors: Tariel Kikvadze Tariel Kikvadze , Temur Shakiashvili Temur Shakiashvili
Published: March 2023

The article provides alternative definitions of poverty. The various and interrelated factors affecting it are analyzed, which are often random in nature. Accordingly, the necessity of using adequate statistical methods is emphasized. Several essential factors for calculating the poverty rate have been identified. The Cobb-Douglas neoclassical production function, which has been widely used in empirical research since the 20s of the last century, is used to construct the model. The theoretical justification of the model is based on Keynes' concept of the relationship between the employment rate, aggregate demand and total output. The absolute indicator is taken as the measure of poverty, and the volume of investments, Gini and freedom indices are the factors affecting it. In order to solve the model by the method of least squares, they were linearized by means of logarithms.
On the basis of the constructed, statistically significant econometric model, appropriate conclusions are drawn. The degree of adequacy of the model can be increased with the increase in the volume of statistical data and/or in case of highlighting any other essential factors affecting poverty.
Keywords: poverty, poverty line, aggregate demand, total output, production function, economic freedom index, Gini coefficient, investment rate, least squares method, econometric model.
Anesthetic support during total laryngectomy: current status and feasibility of optimization
Authors: Shkitak Inna , Kobelyatsky Yuriy
Published: March 2023

Topicality: Despite progress in global medicine, optimization of surgical treatment of laryngeal cancer remains an urgent task due to adverse postoperative consequences and poor patient survival. Anesthetic support during total laryngectomy needs to be improved due to the possible undesirable effect of the standard scheme of intraoperative management of patients.
Aim: to evaluate the effectiveness of anesthetic support during total laryngectomy using standard doses of opioids, the severity of side effects in the early postoperative period, and the feasibility of finding alternative pain relief schemes.
Materials and methods: 25 patients with T3-4N0-3M0 laryngeal cancer who underwent radical surgical treatment were examined. During total laryngectomy, patients were anesthetized using standard doses of opioids without the use of adjuvant components of anesthesia. Anesthesia control was carried out on the basis of monitoring the bispectral index (BIS) and changes in the index of analgesia and nociception (ANI). In dynamics, biochemical and immunological studies of the blood of patients were carried out. Assessment of pain syndrome was carried out according to VAS indicators.
Statistical analysis was carried out using classical methods of descriptive and analytical statistics using the software product STATISTICA v.6.1 (Statsoft Inc., USA, license number AGAR909E415822FA).
Results and discussion: An analysis of anesthetic support during total laryngectomy using standard doses of opioids showed that the condition of patients after surgery is characterized by a certain immunosuppression with lymphopenia, a decrease in the level of interleukin 2 and tumor necrosis factor alpha, which lasts 48 hours and is most pronounced at 2-day after surgery.
As a result of the study, the dependence of the pain syndrome in patients with total laryngectomy on the injected dose of opioids was revealed – the more opioids are used intraoperatively, the more patients needed them after the operation. This phenomenon is associated with the sensitization of opioid receptors and the development of tolerance, which further leads to hyperalgesia.
An increase in the dose of the painkiller also led to an immunosuppressive effect in the examined patients, which was manifested primarily in a decrease in the level of IL-2, which is a potentially unfavorable factor in the proliferation and subsequent invasion of cancer cells.
Conclusions: From the given data, it follows that the introduction of new anesthetic schemes using the principles of multimodal anesthesia and the principles of opioid-limiting anesthesia should be used in patients with laryngeal cancer during total laryngectomy.
Peculiarities of the acoustic reflex registration thresholds in relation to the parameters of the thresholds tone audiometry in patients with acute combat trauma
Authors: Shidlovskaya Tetiana A. , Shidlovskaya Tamara V. , Kureneva Kateryna Yu. , Kozak Nikolay S. , Shevtsova Tetiana V.
Published: March 2023

Aim: study of threshold ratios between indicators of acoustic impedance and threshold tonal audiometry in military personnel – participants in hostilities.
Materials and methods: the results of audiometric and impedancemetric examinations of 43 servicemen aged 18 to 42 years who received combat acute trauma in the period March-August 2022 and 20 patients with severe sensorineural deafness (2, 3, 4 stages according international classification) of non-acutraumatic genesis as a comparison group.
Results and their discussion: During the examination of 43 soldiers, it was found that with significant sensorineural hearing loss on both sides (3 and 4 stages according international classification), the patients registered a full-fledged acoustic reflex during ipsilateral and contralateral stimulation. When conducting an impedanceometric examination of patients in the comparison group, it was found that in most patients the acoustic reflex was not registered at all.
Conclusions:
1. In combat acute acoustic trauma, it is possible to register acoustic middle-ear-muscle reflex with severe hearing loss, which may be caused by damage to the receptor part of the auditory analyzer and the accompanying symptom of the phenomenon of accelerated loudness, by a central mechanism, or by a combination of central and peripheral mechanisms.
2. Dissociation of acoustic middle-ear-muscle reflex threshold values and threshold tonal audiometry is a characteristic feature of acutraumatic damage to the auditory analyzer.
3. Identified features, such as registration of acoustic middle-ear-muscle reflex in severe hearing loss, dissociation of acoustic reflex thresholds and tonal audiometry may be useful for further study of the pathogenesis of combat acute trauma, which, in turn, will contribute to improving the quality of diagnosis and finding ways to correct disorders of the auditory system in individuals, who suffered as a result of hostilities.
Subgraph Densities in $K_r$-Free Graphs
Authors: Grzesik Andrzej , Győri Ervin , Salia Nika , Tompkins Casey
Published: March 2023

In this paper we disprove a conjecture of Lidický and Murphy about the number of copies of a given graph in a $K_r$-free graph and give an alternative general conjecture. We also prove an asymptotically tight bound on the number of copies of any bipartite graph of radius at most~$2$ in a triangle-free graph.
Nonexistence of Almost Moore Digraphs of Degrees 4 and 5 with Self-Repeats
Authors: López Nacho , Messegué Arnau , Miret Josep M.
Published: March 2023

An almost Moore $(d,k)$-digraph is a regular digraph of degree $d>1$, diameter $k>1$ and order $N(d,k)=d+d^2+\cdots +d^k$. So far, their existence has only been shown for $k=2$, whilst it is known that there are no such digraphs for $k=3$, $4$ and for $d=2$, $3$ when $k\geq 3$. Furthermore, under certain assumptions, the nonexistence for the remaining cases has also been shown. In this paper, we prove that $(4,k)$ and $(5,k)$-almost Moore digraphs with self-repeats do not exist for $k\geq 5$.
Small Graphs and Hypergraphs of Given Degree and Girth
Authors: Erskine Grahame , Tuite James
Published: March 2023

The search for the smallest possible $d$-regular graph of girth $g$ has a long history, and is usually known as the cage problem. This problem has a natural extension to hypergraphs, where we may ask for the smallest number of vertices in a $d$-regular, $r$-uniform hypergraph of given (Berge) girth $g$. We show that these two problems are in fact very closely linked. By extending the ideas of Cayley graphs to the hypergraph context, we find smallest known hypergraphs for various parameter sets. Because of the close link to the cage problem from graph theory, we are able to use these techniques to find new record smallest cubic graphs of girths 23, 24, 28, 29, 30, 31 and 32.
PENGARUH RADIASI MATAHARI DAN JENIS MATERIAL COIL PADA PV-MODULE SOLAR ELECTRIC COOKER
Authors: Asrori Asrori , Harie S. Jaya
Published: March 2023

Global energy needs are increasing, while world energy reserves derived from fossils are dwindling. Therefore, a breakthrough is needed to develop green technology based on renewable energy, especially in the household sector. Indonesia is located on the equator so it has great potential to explore solar energy sources. This study aims to analyze the effect of the type of coil heater material and the level of solar radiation on the PV module solar electric cooker. Testing carried out in the Solar Energy Lab., Mechanical Engineering, State Polytechnic of Malang (7°56ʼ36.4ˮS ; 112°36ʼ49.6ˮE). The method used is true experimental using three material types based on their thermal conductivity, namely copper, aluminum, and nickel as well as the change in solar radiation on the heat of solar electric cooker generated by the PV module. The results showed that there was an effect of the parameters of thermal conductivity and changes in solar radiation on the heat generated by the PV module solar electric cooker. In the nickel coil test, it can reach a temperature of 769°C at a solar radiation of 875.9 W/m2. Testing the aluminum coil obtained a temperature of 191°C at a solar radiation level of 931.4 W/m2, and a copper coil could produce a temperature of 169°C at a solar radiation level of 855.6 W/m2
MINYAK ATSIRI BERBAHAN KULIT JERUK DAN BUNGA KENANGA SEBAGAI AROMA TERAPI PADA MATA KULIAH PERAWATAN BADAN
Authors: Nuraini Iut , Fitria Hansyah Fatmasari  , Ria Andriani Mukti
Published: March 2023

Aromatherapy is a material used by students in body care courses to improve fitness and is an important aspect so that the activities carried out can be optimal, but students often complain that the use of aramotherapy is expensive and wasteful. This needs efforts to overcome it with non-pharmacological therapies such as aromatherapy of essential oils made from orange peel and ylang flowers. The purpose of this study was to analyze the use of essential oil aromatherapy made from orange peel and ylang flowers from the aspect of cost efficiency in PVKK students, Faculty of Engineering, PGRI Adi Buana University, Surabaya. The method used in this study is making aromatherapy with organoleptic tests and conducting analysis conclusions. The results of research that has been carried out experiments and tested that the essential oils of orange peel and ylang flowers can be used as aromatherapy. The conclusion is that the essential oils from orange peel and ylang flowers have a good aroma, and are very affordable from an economical point of view when compared to other aromatherapy treatments
KONTRIBUSI PERSEPSI LINGKUNGAN, KOMPETENSI KERJA, DAN K3 TERHADAP KINERJA PEGAWAI
Authors: Pramudibyo Sugeng , Yayi Febdia Pradani  , Cornelia Tjiptady Bella
Published: March 2023

The high number of work accidents that occur in Indonesia causes many economic losses for both employees and companies. The aims of this study included knowing the effect of OSH implementation on performance, the influence of the work environment on performance, the influence of competence on performance, and the effect of OSH implementation, work environment, and competence on the performance of SMK alumni employees in the AHASS workshop in Malang City. The population in this study were all AHASS workshop mechanics in the city of Malang. Sampling was carried out by proportional random sampling and obtained as many as 118 people. The research design uses a correlational quantitative design. The results showed that there was a significant contribution between K3, work environment, and competency on the performance of SMK alumni employees in the AHASS workshop in Malang City. This is indicated by the contribution value of 63.4%. Partially, the application of OSH contributed 30.22%, perceptions of the work environment contributed 15.12%, and competence contributed 17.8%. So the conclusion from this study is that OSH, work environment, and competence each have an influence on the performance of SMK alumni employees. All three simultaneously have a significant contribution to performance. So it is hoped that the AHASS workshop can create a comfortable and safe work environment for employees, besides that mechanics are also expected to always improve the application of K3 at work.
Self-Compassion dan Self-Esteem pada Narapidana
Authors: Amita Nindy , Siregar Juliarni , Listyani Nilla , Assyfa Laras
Published: March 2023

The purpose of the researchers was to find out whether self-compassion and self-esteem among inmates at Detention X. Researchers compared and identified the levels of self-compassion and self-esteem according to demographic data. The research sample was 145 male prisoners in prison. The sampling technique used purposive sampling method. The results of this study show that 18.7% of the sample is in low self-compassion and 30.35% of the sample is in the low self-esteem category. The results of the correlation analysis carried out in knowing the relationship of the two research variables is that there is a negative relationship between self-compassion and self-esteem. Self-compassion and self-esteem in prisoners with different forms of study so that the components seen correspond to the aspects in these variables. This study concluded that research respondents showed self-compassion and self-esteem had a negative relationship. In practical terms, the implications of this research can be used as an initial process to find out the description of the situation of prisoners in prisons.
Implementasi Bantuan Pembangunan Program Air dan Sanitasi USAID IUWASH PLUS di Indonesia Tahun 2021
Authors: Farid Ramadhan Andi Muhammad , Zahidi M. Syaprin
Published: March 2023

This study aims to analyze the implementation of the USAID IUWASH PLUS 2021 water and sanitation program development assistance in Indonesia. Due to the clean water and sanitation problems in Indonesia, the United States government, through USAID, distributes aid in the form of grants. This research applies a qualitative research method with a case study approach. The collected data were analyzed using the concepts of foreign aid and aid effectiveness. The results of this study found that the authors linked the principles contained in the Paris Declaration such as the principle of ownership, the principle of local harmony, the principle of harmonization, the principle of management and the principle of shared responsibility. The USAID IUWASH PLUS program is effective in improving water and sanitation services in Indonesia, referring to the results published by USAID in the February 2022 Final Report.
Optimization of Non-Convex Economic Dispatch Problem Using Hybrid Approach Based on Bacterial Foraging and Genetic Algorithm
Authors: Shakoor Abdul
Published: March 2023

Fulfillment of consumer demand is a foremost challenge for all electrical power utilities. An electrical power system consists of several generating units and each of these units owns a distinct operating set of operating parameters. A fundamental challenges lies in a fact that there may not be a correlation between operating costs of these machines and their generated output. Major reason for lack of the correlation includes the ramp-rate limits, transmission losses and manipulation due to valve-points in the generation units cost function, and thus, it becomes a non-linear optimization problem. In view of this fact, it creates a rigorous need to devise a robust solution to cater for such a non-linear optimization scenario. In this paper, bacterial foraging and genetic algorithms based hybrid technique is used to effectively tackle the economic dispatch problem. The presented technique incorporates two modifications in the original bacterial foraging algorithm including differential evolution inspired bacterial movement and genetic algorithm based bacterial reproduction. Where inspired bacterial movement involves modification in the directional movement for each bacterium in such a manner that every bacterium tries to improve its direction and position based on differential evolution. The proposed technique is applied to non-convex dynamic economic dispatch (DED) problem in order to obtain optimal solution within feasible functional limits while satisfying the load demand at the same time. The obtained results demonstrate that the proposed hybrid approach outperform the other techniques in term of optimal solution and significant reduction of computational time in the given scenarios.
On a six-dimensional Artificial Neural Network Model
Authors: Samuilik Inna
Published: March 2023

This work introduces a new six-dimensional system with chaotic and periodic solutions. For special values of parameters, we calculate the Kaplan-Yorke dimension and we show the dynamics of Lyapunov exponents. Some definitions and propositions are given. Visualizations where possible, are provided.
Dictamen 1/19 del TJUE sobre el Convenio de Estambul sobre la Prevención y Lucha contra la Violencia contra la Mujer y la Violencia Doméstica: entre el rigor y el pragmatismo
Authors: Castillo de la Torre Fernando
Published: March 2023

El proceso de celebración del Convenio de Estambul sobre la Prevención y Lucha contra la Violencia contra la Mujer y la Violencia Doméstica por parte de la UE y los Estados miembros ha estado plagado de tensiones políticas y jurídicas. Esta contribución examina el Dictamen 1/19, en el que el Tribunal de Justicia abordó la base jurídica y varias cuestiones de procedimiento que son fundamentales para el funcionamiento de los acuerdos mixtos. El análisis expone las soluciones que aporta el Tribunal de Justicia, que combinan el rigor y un cierto pragmatismo, y reflexiona sobre la reticencia del Tribunal de Justicia a tratar determinadas cuestiones relativas al encaje de los acuerdos mixtos en el Derecho internacional.
Fiscalía europea versus Olaf. Una propuesta en torno a la peculiar atribución de competencia sobre investigaciones contra personas jurídicas
Authors: Vicario Pérez Ana María
Published: March 2023

El presente trabajo tiene por objeto estudiar la competencia de la Fiscalía Europea en la investigación de conductas de fraude contra los intereses financieros comunitarios cometidas por personas jurídicas, al tiempo que efectuar una comparación con las funciones investigadoras correspondientes a la OLAF. Así, comenzaremos analizando la posible inclusión de las entidades en el ámbito de aplicación personal del nuevo órgano europeo de instrucción. Partiendo de ello, nos centraremos en examinar su competencia material, distinguiendo su alcance en función de si la conducta cometida por la entidad tiene la consideración de delito o de infracción administrativa, por haberse dado en un Estado defensor o no del principio societas delinquere potest. Se abordarán así las diferencias entre las investigaciones efectuadas por la Fiscalía Europea en causas delictivas y las acometidas por la OLAF en caso de infracciones administrativas. Finalizaremos con unas reflexiones en torno al obstáculo que supone para la conformación del Espacio Judicial Europeo la diferente atribución de competencias investigadoras a uno u otro órgano en función del país donde la persona jurídica haya desarrollado su actuación.
A vueltas con la responsabilidad por leyes contrarias al Derecho de la Unión Europea
Authors: Guichot Reina Emilio
Published: March 2023

La aplicación del principio de responsabilidad del Legislador por infracciones del Derecho de la Unión Europea ha estado sometida en nuestro Derecho a grandes vaivenes. El Tribunal Supremo consideró inicialmente que estas reclamaciones no eran equivalentes a las relativas a la responsabilidad del Legislador por leyes inconstitucionales y, por ello, que no se requería aplicar los mismos requisitos procesales ni sustantivos. Este planteamiento fue rechazado en la Sentencia del Tribunal de Justicia de la Unión Europea Transportes Urbanos, a partir de la cual el Tribunal Supremo comenzó a “igualar a la baja” el régimen procesal, sin unificar, sin embargo, el régimen de fondo. El Legislador de las Leyes 39 y 40/2015 procedió a una regulación de la responsabilidad del Legislador la aplicación de leyes contrarias a la Constitución y al Derecho de la Unión europea similar en sus requisitos procesales, esta vez “igualando al alza”, y mantuvo un régimen sustantivo dispar, más generoso en el primer caso y alineado con el requisito de ilegalidad grave sustantiva establecido como mínimo por el Tribunal de Justicia de la Unión Europea. La Sentencia Comisión contra Reino de España de 28 de junio de 2022 ha enjuiciado el régimen legal español, detectando las contradicciones con el Derecho de la Unión de sus determinaciones procesales desde la perspectiva del principio de efectividad. Además, en cuanto a los requisitos de fondo, ha optado por una novedosa interpretación de la articulación del estándar europeo y las regulaciones nacionales. En el trabajo se lleva a cabo una valoración de esta jurisprudencia y se añaden unas reflexiones para el debate entre la diferencia entre requisitos de fondo y procesales, la relación entre la tutela primaria” y la acción de responsabilidad o sobre el carácter objetivo o culposo de la responsabilidad del Legislador.
Nėštumų baigtys po pagalbinio apvaisinimo procedūrų ne moters kūne. Literatūros apžvalga
Authors: Vankevičienė Karolina , Vaigauskaitė Brigita , Paliulytė Virginija , Ramašauskaitė Diana
Published: March 2023

Pagalbinis apvaisinimas – tai procedūros, kurios pasitelkiamos nevaisingumui gydyti. Procedūrų metu atliekamos manipuliacijos su kiaušialąstėmis ir spermatozoidais ne žmogaus organizme, kurių tikslas – moters nėštumas. Šiuo metu tiek Europoje, tiek JAV daugiau nei 2 proc. naujagimių gimsta po pagalbinio apvaisinimo procedūrų. Skaičiuojama, jog kasmet Lietuvoje tokiu būdu gimsta daugiau nei 300 naujagimių. Nėštumo po pagalbinio apvaisinimo perinatalinė baigtis laikoma gera, jei naujagimis gimsta laiku ir normalios kūno masės. Stebint didėjantį tokių nėštumų dažnį, atliekama vis daugiau tyrimų, kuriuose vertinamas pagalbinio apvaisinimo procedūrų saugumas, su motinos ir vaisiaus sveikata susijusi rizika. Atliktuose moksliniuose tyrimuose aprašomos tiek ankstyvosios, tiek vėlyvosios perinatalinės komplikacijos. Vis dėlto mokslinius tyrimus šioje srityje atlikti sudė- tinga, nes nelengva atskirti, ar komplikacijos yra susijusios su pagalbinio apvaisinimo procedūrų metu atliekamomis manipuliacijomis, ar susijusios su tokiais veiksniais, kaip tėvų amžius, aplinkos veiksniai ir kt. Šiame straipsnyje apžvelgiama mokslinė literatūra apie nėštumų baigtis po pagalbinio apvaisinimo procedūrų ne moters kūne.
Vėmimas nėštumo metu. Klinikinis atvejis
Authors: Kržčonavičiūtė Saulė , Vaitkevičiūtė Marija , Ramonienė Gitana
Published: March 2023

Pykinimas ir vėmimas nėštumo laikotarpiu yra būklė, kuri, nenustačius priežasties ir neskyrus adekvataus patogenetinio arba simptominio gydymo, gali turėti poveikį nėščiosios ir vaisiaus sveikatai bei sąlygoti gyvybei pavojingas komplikacijas. Šiame straipsnyje pateikiama 1 tipo cukriniu diabetu sergančios bei nerimo sutrikimą turinčios nėščiosios vėmimo viso nėštumo laikotarpiu atvejis, nustatytas 2021 m. Lietuvos sveikatos mokslų universiteto ligoninės Kauno klinikų Akušerijos ir ginekologijos klinikoje.
Žmogaus papilomos viruso infekcijos įtaka priešlaikiniam gimdymui. Mokslinės literatūros apžvalga
Authors: Žilinskaitė Gintarė , Radavičiūtė Ieva , Bužinskienė Diana
Published: March 2023

Priešlaikinis gimdymas – tai pagrindinė naujagimių sergamumo ir mirtingumo priežastis visame pasaulyje. Su priešlaikiniu gimdymu yra susiję maždaug 75 proc. naujagimių mirčių. Neretai lyties organų virusinės infekcijos sutrikdo gimdos kaklelio epitelio apsauginį barjerą ir sukelia priešlaikinį gimdymą. Žmogaus papilomos virusas (ŽPV) yra dažniausia lytinių takų virusinė infekcija. ŽPV gali daugintis trofoblasto ląstelėse bei sąlygoti placentos disfunkciją ir spontaninį priešlaikinį gimdymą. Literatūroje vis dažniau keliami klausimai, ar ŽPV infekcija yra susijusi su priešlaikiniu gimdymu, savaiminiu persileidimu, priešlaikiniu neišnešioto vaisiaus dangalų plyšimu, vaisiaus intrauterinio augimo sulėtėjimu, mažu naujagimių gimimo svoriu, netgi su vaisiaus mirtimi. Nustatyta, kad didelės rizikos ŽPV infekcija – savaiminio priešlaikinio gimdymo rizikos veiksnys. ŽPV sukelta gimdos kaklelio displazija, teigiami ŽPV 16 arba ŽPV 18 tipai tarp pirmo ir trečio nėštumo trečdalių bei gydymas nuo didelio laipsnio gimdos kaklelio intraepitelinės neoplazijos eksciziniais metodais taip pat yra susiję su didesne priešlaikinio gimdymo rizika. Profilaktinė vakcina nuo ŽPV bei moterų gimdos kaklelio vėžio patikros programa gali sumažinti priešlaikinio gimdymo riziką. Tačiau reikalingi kokybiškesni, didelės imties moksliniai tyrimai, kad būtų sukurtos patikimesnės rekomendacijos, padedančios sumažinti nėštumo komplikacijas, susijusias su didelės rizikos ŽPV infekcija.
Moterų psichologiniai sunkumai po gimdymo
Authors: Grigaliūnienė Viktorija , Karaliūnaitė-Skrickienė Vaiva , Jarienė Kristina , Jaras Algirdas
Published: March 2023

Dėl atsiradusių pokyčių gyvenime laikotarpis po gimdymo yra žinomas kaip padidėjusio pažeidžiamumo bei rizikos naujai arba pakartotinai atsirasti moterų psichikos sutrikimams. Ankstyvas perinatalinių psichikos sutrikimų nustatymas ir veiksmingas valdymas yra labai svarbūs moterų ir jų vaikų gerovei. Straipsnyje apžvelgiami galimi pogimdyminių nuotaikos sutrikimų tipai bei pateikiamos rekomendacijos, kaip laiku juos atpažinti.
Impact of Tender Price Variability on Economic Sustainability of Construction Sector in Developing Countries
Authors: Tembo Moffat , Mwanaumo Erastus Misheng'u , Kahanji Charles
Published: March 2023

Economic sustainability in the construction sector is increasingly important in developing countries, and threats from construction tender price variability and inflation require immediate action. While global trends emphasize sustainable construction practices triggered by rapid economic growth and augmented environmental impact considerations, this paper underscores the significance of adopting tender-price practices that focus on attaining economic sustainability for enhancing sustainable development in developing countries. The study predicates how construction tender price variability accentuates sustainable construction practices. The study identified respondents through purposive sampling for better insights and a more thorough investigation of the construction tender-price phenomena. The adopted method presented the study with information-rich participants and cases regarding issues of central significance to the inquiry. In addition, the study utilized snowball sampling in which existing respondents recruited or referred other respondents from among their professional acquaintances. The study findings 13 factors requiring immediate consideration to address construction tender price variability and inflation. These include material costs; interest rates; equipment costs; labor costs; delayed payments; exchange rates; and the nature and type of project. The results categorize four specific areas significantly affected by high construction tender prices. The harmful impacts were immediate and more severe to stakeholders like the government (client). The effect on projects is equally devastating; however, contractors appear to experience more positive-impact though in the short term. The long-term effects of high construction tender-price variability inflation were detrimental to all stakeholders by observation. Thus, the article recommends strategies that address tender price sustainability challenges faced in the construction sector.
Uso de datamining y analisis de clúster para mejorar la productividad de Mipymes de la Ciudad de Pilar
Authors: Ríos Vargas Alberto Luis , Rios Nicoli Brian Marin
Published: March 2023

El objetivo de este trabajo es proporcionar a los usuarios empresariales conocimientos de las características operativas y de rendimiento en los aspectos de producción del negocio. El mismo presenta un enfoque metodológico para desarrollar una métrica práctica de recopilación de datos para la productividad basada en factores de influencia establecidos en los emprendimientos de carácter industrial.

Este estudio se realizará utilizando una técnica de Datamining denominada “Clúster Analysis” o análisis de clústeres, que permite identificar dentro de un conjunto de datos, un determinado grupo de usuarios según características comunes
Üniversite Öğrencilerinde Akıllı Telefon Bağımlılığı ile Fiziksel Aktivite, Yorgunluk ve Uyku Kalitesinin İlişkisinin İncelenmesi
Authors: BASKAN Özden , ÇORUM Muammer , BÜYÜKYILMAZ Güler
Published: March 2023

Çalışmanın amacı üniversite öğrencilerinde akıllı telefon bağımlılığı ile fiziksel aktivite, yorgunluk düzeyi ve uyku kalitesi arasındaki ilişkinin incelenmesidir. Çalışmaya 140 üniversite öğrencisi dahil edildi. Katılımcıların demografik verileri kaydedilmiştir. Bunun yanında akıllı telefon bağımlılığı ölçeği kısa formu, uluslararası fiziksel aktivite anketi kısa formu, yorgunluk şiddet ölçeği ve Pittsburg uyku kalitesi indeksi kullanılmıştır. Çalışmamızın yaş aralığı 18-32 olup yaş ortalaması 20,88±2,43 ve vücut kitle indeksi (VKİ) ise 22,19±4,16 olan 140 öğrenci dahil edilmiştir. Katılımcılarda akıllı telefon bağımlılığı ölçeği ile yorgunluk şiddet ölçeği arasında pozitif yönde ‘orta’ düzeyde bir ilişkinin olduğu belirlendi (r=0,422, p0,05). Fiziksel aktivite anketi ile yorgunluk şiddeti ölçeği arasında negatif yönde ‘zayıf’ düzeyde bir ilişkinin olduğu belirlendi (r=-0,208, p
Clinical, Demographic and Prognostic Evaluation of Patients Admitted the Emergency Department with Mushroom Poisoning
Authors: YILDIRIM Sinan , VARIŞLI Behçet , AKMAN Canan , ATAÇ Kenan , ÇAKIR Okan
Published: March 2023

Fungal intoxications can lead to a variety of conditions ranging from simple gastroenteritis to severe neurological manifestations, and even fatal liver and kidney failure. In this study, we aimed to evaluate the diagnosis, treatment, prognosis and demographic data of patients admitted to the emergency department due to fungal intoxication. The aim of this study was to conduct a retrospective evaluation of examination findings, laboratory investigations, duration of treatments, hospitalization rates, and mortality rates in patients admitted to our emergency department due to fungal intoxication between October 01, 2017 and October 01, 2018. Of the 40 patients included in the study, 25 (62.5%) were female, with a mean age of 44.83 ± 17.00 years and a range of 18 to 82 years. Nausea and vomiting had the highest frequency (28 patients) among the presenting complaints of the patients. Only 11 (27.5%) patients underwent gastric lavage and decontamination with activated charcoal, whereas 29 (72.5%) patients had no gastric decontamination. The highest frequency of admissions was recorded in November. The highest frequency of patient admissions was between 01:00 and 02:00. It was concluded that there was a low rate of the administration of gastric decontamination in patients admitted to the emergency department, especially those admitted to the ward. In our study, the majority of patients with fungal intoxication had early-onset mild symptoms. Particular attention should be paid to early diagnosis and adherence to appropriate treatment algorithms in emergency departments, particularly in patients presenting with late-onset symptoms that may result in mortality.
Sağlık Hizmetleri Finansmanı ve Geri Ödeme Yöntemleri: Teşhis İlişkili Gruplar Uygulama Örneği
Authors: SAYAR Burak , AĞIRBAŞ İsmail
Published: March 2023

Sağlık hizmetlerinin finansmanı, bir sağlık sisteminin sürdürülebilirliğini, etkililiğini ve performansını etkileyen temel unsurudur. Uygun bir geri ödeme yöntemi sağlık hizmetlerinin finansman sorununu ortadan kaldırarak sağlık hizmetlerinin sunulmasını sürdürülebilir kılacaktır. Bu çalışmanın amacı, Sağlık Bakanlığı’na bağlı 235 yataklı B grubu genel bir hastanenin Teşhis İlişkili Gruplar verisi ışığında 2019 yılına ait Vaka Karması İndeksini (VKİ) hesaplayıp hizmet sunulan hasta grubunun kompleksliğini saptamaktır. Hastanenin 2019 yılına ait, ortalama hastane yatış gün sayısı, taburcu sayısı, yoğun bakım yatış gün sayısı, hastane yatış gün sayısı ve TİG verileri değerlendirmeye alınmıştır. Hastanenin toplam bağıl değeri vaka sayısına bölünerek aylık Vaka Karması İndeksi hesaplanmıştır. Aylık olarak TİG verileri incelenip hastanenin hangi aylarda daha komplike, hangi aylarda daha az komplike vakalara bakıldığı saptanmıştır. Aylık VKİ değerlerinin ortalaması hesaplanarak hastaneye ait 2019 yılına ait VKİ hesaplanmıştır. Verilerin düzenlenmesinde ve analizinde M. S. Excel programı kullanılmıştır. Hastanede 2019 yılında 2039 kodda 15.571 hastaya hizmet sunumu gerçekleştirilmiştir. 2019 yılına ait vaka karması indeksi 0,81 olarak bulunmuştur. VKİ en yüksek mart (0,88) ayında gerçekleşmiştir. Sağlık kurumlarının sağlık hizmetini talebini karşılamaları mevcut kaynakların hakkaniyet çerçevesinde kullanılmasıyla mümkündür. Kaynakların hakkaniyete uygun dağılmasının yanı sıra geri ödeme yöntemleri de önem arz eden bir diğer husustur.
Estetik Liderlik Ölçeğinin Sağlık Çalışanları İçin Uyarlanması
Authors: FİLİZ Mustafa , GÜNGÖR Sümeyye
Published: March 2023

Bu çalışmada “Estetik Liderlik Ölçeğinin” sağlık alanına uyarlanması amaçlanmıştır. Çalışma Türkiye geneli 464 sağlık çalışanın katılımıyla gerçekleştirilmiştir. Estetik liderlik ölçeği ve kişisel bilgi formu ile veriler toplanmıştır. Verilerin analizinde tanımlayıcı istatistiki analizler, keşfedici ve doğrulayıcı faktör analizi, güvenilirlik analizi ve boyutlar arasında korelasyon analizi kullanılmıştır. Analizler, Excel, SPSS 25 ve AMOS paket programları yardımıyla gerçekleştirilmiştir. Elde edilen bulgulara göre, ölçeğin alt boyutlarından estetik görünümün ortalama değerde en yüksek ortalamaya sahip ve estetik yaklaşımın ise en az ortalamaya sahip boyut olduğu görülmüştür. Ölçeğin 7 faktör altında toplandığı ve ölçekte toplam varyans %72,133 olarak saptanmıştır. Ölçeğin faktör yapısıyla uyum içerisinde olduğu görülmüştür. Eğitim alanda geliştirilen ‘‘Estetik Liderlik Ölçeğinin’’ sağlık alanında da geçerli ve güvenilir bir ölçek olduğu görülmüştür.
Üniversite Öğrencilerinin Ruh Sağlığı Okuryazarlığı ve Psikolojik Sağlamlık Düzeylerinin Değerlendirilmesi
Authors: POLAT Sibel
Published: March 2023

Ruh Sağlığı Okuryazarlığı (RSO), ruhsal bozukluklarla ilgili bilgi ve inançları tanımayı, ruhsal bozuklukları önleme ve yönetmeyi, aynı zamanda ruhsal bozukluklarda yardım arama davranışını sağlayan, sağlık okuryazarlığının bir alt kümesidir. Araştırma, sağlık temalı bir vakıf üniversitesinin lisans bölümlerine kayıtlı 268 öğrenci ile yürütülmüştür. Bu araştırmada; üniversite öğrencilerinin ruh sağlığı okuryazarlığı ve psikolojik sağlamlık düzeylerini değerlendirmek ve bunlar arasındaki ilişkiyi belirlemek amaçlanmıştır. Araştırmada veriler; Kişisel Veri Toplama Formu, Ruh Sağlığı Okuryazarlığı Ölçeği (RSOY) ve Kısa Psikolojik Sağlamlık Ölçeği (KPSÖ) aracılığıyla toplanmıştır. Öğrencilerin KPSÖ puan ortalaması 15,29±4,00; RSOY puan ortalaması 16,60±2,80’dir. Stresli bir olay yaşayan ve antidepresan kullanan öğrencilerin KPSÖ puan ortalamalarının daha düşük olduğu belirlenmiştir (p
Behaviors and Attitudes towards Personal Protective Equipment Use: A Cross-Sectional Study among Physiotherapy Interns during COVID-19
Authors: BİRİNCİ Tansu , ARSLANTÜRK Ayça , SEVİNÇ GÜNDÜZ Merve , ŞEN Meltem , KAYA MUTLU Ebru
Published: March 2023

Internships are vital for preparing young healthcare workers for the working life. Examining the behaviors and attitudes of interns about the use of personal protective equipment (PPE) and raising their awareness will contribute to the fight against contagious diseases. This study aimed to investigate the behaviors and attitudes towards PPEs in the physiotherapy interns during the COVID-19 pandemic. Two hundred twenty-three physiotherapy interns (mean age, 22.55±1.80 years; 162 female) were included into study. The health-related characteristics, vaccination status, use of PPE against the COVID-19, behaviors and attitudes towards PPEs use, and the physical complaints related to the PPEs were questioned. A total of %43.2 interns have tested positive for COVID-19 during the internship. All participants preferred to wear the mask, while %95.1 used protective gloves in case of COVID-19 risk, and %66.4 of the participants stated that they were worried about finding new equipment while removing the PPEs. The most frequently reported physical complaints were dryness, irritation, and scar in the hands. PPEs are essential in protecting against epidemics and infectious diseases that threaten public health; therefore, healthcare systems must prioritize the procurement and distribution of PPEs, and provide adequate training to interns in its use.
A Study on the Evaluation of Nutritional Status of University Students in Şırnak Province
Authors: YILDIZ Anıl , ALPHAN Müveddet Emel
Published: March 2023

In this study, it was aimed to determine the daily nutrient consumption amounts and nutritional diversity in the diets of Şırnak University students using the Healthy Eating Index (HEI-05). It was conducted by applying a face-to-face questionnaire on 148 students selected by random sampling method from among the students studying at Şırnak University Silopi Vocational School and accepting to participate in the study. 24 hours food consumption records of the students were taken and nutrients were analyzed using the BEBIS program. The majority of the students participating in the survey were male students (58.8%). The Healthy Eating Index score average of female students was higher than that of male students and it was determined as 65.74 ±11.45 for females and 63.56 ± 11.53 for males. A significant difference was found between the genders of the students and energy, cholesterol and sodium score averages that they consumpted daily by diet. According to the results of this research, Healthy Eating Index scale scores show that students' nutritional habits should be improved. Determining the food consumption and nutritional habits of higher education students can be beneficial for the prevention of nutrition related diseases.
Sosyal Medya Bağımlılığının Sosyal Kaygı Üzerindeki Etkisinin İncelenmesi
Authors: ARSLAN Kübra , ABRA Dilek , ERBAŞ Duygu , YÜCELOĞLU Seçil , ERDUGAN Sevilcan
Published: March 2023

Teknoloji, dünyanın her noktasına ulaşan bireylerin hayatlarını kolaylaştırarak önemini giderek arttıran bir olgu halini almıştır. Gelişen teknoloji ile birlikte artan internet kullanımı bireylere iş, eğitim ve sosyal açılardan fayda sağlasa da zamanla olumsuz etkilerini de beraberinde getirmiştir. Bu olumsuzluklar arasında sosyal medya kullanımının artması sonucu gelişen sosyal medya bağımlılığı da sayılmaktadır. Bu çalışmada; sosyal medya bağımlılığının sosyal kaygı düzeyleri üzerindeki etkisinin incelenmesi amaçlanmıştır. Bu araştırma, nicel metot ile ilişkisel tarama türünde yapılmıştır Çalışmaya 263 kadın ve 68 erkek olmak üzere 331 üniversite öğrencisi katılmıştır. Araştırmada “Sosyal Medya Bağımlılığı Ölçeği-Yetişkin Formu”, “Sosyal Medya Kullanıcıları İçin Sosyal Kaygı Ölçeği”, “Başa Çıkma Tutumlarını Değerlendirme Ölçeği COPE-R” ve “Kişisel Bilgi Formu” kullanılmıştır. Elde edilen bulgulara göre öğrencilerden her birinin en az bir sosyal medya uygulamasına sahip olduğu, günde ortalama 1-3 saat vakit geçirdikleri belirlenmiştir. Öğrencilerin önemli bir çoğunluğunun hiç Facebook kullanmadıkları; önemli oranda Instagram ve YouTube kullanıcısı oldukları tespit edilmiştir. Cinsiyet ile Sosyal Medya Kullanıcıları İçin Sosyal Kaygı Ölçeği ve alt ölçekleri arasında yer alan Gizlilik Endişesi ve Madde Etkileşim arasındaki ilişkinin anlamlı olduğu sonucuna varılmıştır. Kadınların sosyal kaygı düzeyleri erkeklere göre daha yüksektir. Öğrencilerin sosyal kaygı düzeyi ile sosyal medya bağımlılığı arasında pozitif yönde anlamlı bir ilişki olduğu belirlenmiştir.
Hippoterapinin Terapatik Yararları: Ergoterapi Bakış Açısı
Authors: KOÇ Polat , ALTINKAYA Neyran , İNANÇ Gonca
Published: March 2023

Bu derleme makalede, Ergoterapi bakış açısı ile atların ritmik salınımları ve vücut sıcaklığının binicinin lökomotor ve duyusal faaliyetlerini etkilemesi esasına göre çalışan bir rehabilitasyon yaklaşımı olan hippoterapinin terapatik yararlarının ortaya konulması amaçlanmıştır. Son yıllarda hippoterapi ile ilgili yapılan araştırmaların çoğu, özellikle postür, denge, kuvvet, koordinasyon ve sensorimotor programlamayı içeren fiziksel engellere uygulanan rehabilitasyon faydaları üzerine olmuştur. Fiziksel hedeflere ulaşma sırasında hippoterapi uygulamalarının benzersiz yaklaşımı beraberinde sosyal, billişsel, akademik, davranışsal, psikolojik ve iletişim alanındaki sonuçları da etkilemektedir. Hippoterapi uygulamaları sırasındaki tedavi yaklaşımı çok yönlü olup, tüm vücut sistemlerinde olağanüstü etkiler göstermektedir. Hippoterapide doğru yöntem, doğru at ve profesyonel bir ekip ile birçok hastalığın tedavisi ve problemlerinin giderilmesinin mümkün olabileceği görülmektedir. Hippoterapi uygulamalarında profesyonel ekibin içerisinde yer alan Ergoterapistler sağlığı ve refahı aktiviteler yoluyla geliştirirler. Ergoterapistler günlük aktivitelerde motor kontrolü, koordinasyonu, dengeyi, dikkati, duyusal süreçleri ve performansı iyileştirmeyi hedeflemektedir. Bu hedeflerine atın ritmik ve dinamik hareketinden, dokusundan ve sıcaklığından yararlanarak ulaşırlar. Ülkemizde hippoterapinin önemi hekimler ve terapistler tarafından daha derinden anlaşıldıkça daha fazla hasta ve ailelerinin bu tedaviden fayda göreceği öngörülmektedir.