bluuebunny/crossref_metadata_2025 huggingface dataset:
The hamstrings are more impacted than the quadriceps after severe ankle sprain
Authors: Grimandi Ronan , Tissier Florine , Andro Christophe , Tardy Dominique , Gunepin François-Xavier , Rannou Fabrice , Giroux-Metges Marie-Agnès
Published: September 2022

Ankle sprains (AS) are common in the military population, with a prevalence 5 to 8 times higher than that for civilians. The aim of this study was to evaluate in patients with severe AS the impact of disuse on thigh muscle induced by unloading and immobilization due to care. This study focused on muscle trophicity and dynamometric strength. In this observational prospective study, assessments were repeated at 3 visits: close to injury, 15 and 30 days following the sprain. The injured limb was compared to the contralateral limb. A dynamometer assessment was used to monitor changes in strength and fatigue of the thigh muscles of both limbs. Isometric and isokinetic concentric evaluation of peak torque (PTiso and PTdyn), total work (Wt), and peak torque time integral (IPT) of thigh muscles. Full follow-up was obtained in 30 subjects. The injured limbs showed significant deficits in the mean (SD). The quadriceps PTiso and IPT deficits were −12.6% ± 1.9% (P < .0001) and −13.27% ± 1.8% (P < .0001), respectively. The quadriceps PTdyn showed a significant deficit since V2 (−12.2.5% ± 2.0). The quadriceps Wt presented a significant deficit of −4.2% ± 2.4 (P < .0007) at 1 month. The hamstring PTdyn deficit presented a mean loss of −16.5% ± 2.4% (P < .0001). The hamstring Wt deficit was −13.7% ± 2.3% (P < .001). The analysis of variance showed that the grade of the sprain had a significant effect on the quadriceps PTq deficit (P < .016) but not the type of discharge. Our study showed that disuse leads to a significant deficit in the strength of knee muscles within 1 month. It is noteworthy that the hamstrings are more affected than the quadriceps. The rehabilitation protocol to prevent the risk of iterative ankle injuries and secondary knee injuries should incorporate early training of both quadriceps and hamstrings.
Epidermoid cyst in ureter: A case report
Authors: Jing Qiang , Wang Xin , Yuan Xiaobin , Liu Fan , Zhang Xuhui
Published: September 2022

Rationale:

Uro-originated epidermoid cysts, especially located in the upper urinary tract are rare and only 4 cases of epidermoid cyst occurring in the upper urinary tract have been reported worldwide so far. In the previous cases, the cysts were diagnosed as tumors and organs were removed.

Patient concerns and diagnosis:

We report a case of epidermoid cyst in ureter in a 48-year-old female patient admitted to the local hospital suffering from paroxysmal pain in the right hypochondriac for 8 years.

Interventions and outcomes:

She underwent right ureteroscopy in order to rule out the possibility of urinary epithelial carcinoma. The tumor was pathological diagnosed as a benign ureterocyst epidermoid. Postoperatively, the patient showed good recovery. During the 24-month follow-up period, the patient remained well and free of complications.

Conclusion:

This case illustrates that benign epidermoid cysts can appear in the ureter, although it is extremely rare. It also indicates that perioperative examinations must be exhaustive to avoid the further injury to the patients.
Efficacy of albumin with diuretics in mechanically ventilated patients with hypoalbuminemia: A systematic review and meta-analysis
Authors: Itagaki Yuki , Yoshida Naofumi , Banno Masahiro , Momosaki Ryo , Yamada Kohei , Hayakawa Mineji
Published: September 2022

Background:

Hypoalbuminemia is associated with fluid overload, the development of acute respiratory distress syndrome, and mortality. The co-administration of albumin and diuretics for the treatment of patients with hypoalbuminemia is expected to increase urine output, without hemodynamic instability, and improve pulmonary function; however, these effects have not been systematically investigated. Here, we aimed to clarify the benefits of the co-administration of albumin and diuretics in mechanically ventilated patients.

Methods:

We searched for randomized, placebo-controlled trials that investigated the effects of the co-administration of albumin and diuretics compared with placebo and diuretics, in mechanically ventilated patients with hypoalbuminemia. We searched these trials in the Cochrane Central Register of Controlled Trials (CENTRAL), MEDLINE via PubMed, and EMBASE databases. Primary outcomes were hypotensive events after the intervention, all-cause mortality, and the length of mechanical ventilation. Secondary outcomes were improvement in the ratio of partial pressure arterial oxygen and fraction of inspired oxygen (P/F ratio) at 24 hours, total urine output (mL/d), and the clinical requirement of renal replacement therapy (RRT).

Results:

From the 1574 records identified, we selected 3 studies for quantitative analysis. The results of albumin administration were as follows: hypotensive events (risk ratio [RR] 0.33 [95% CI: 0.15 -0.81]), all-cause mortality (RR 1.0 [95% CI: 0.45–2.23]), the length of mechanical ventilation in days (mean difference −0.34 [95% CI: −1.99 to 1.31]), and improvement in P/F ratio (RR 2.83 [95% CI: 1.42–5.67]). None of the randomized controlled trials reported the total urine output, and one reported that no participants required RRT. Adverse events were not reported during the trials. The certainty of evidence was low (in the hypotensive events after the intervention and all-cause mortality) to moderate (in the length of mechanical ventilation in days, improvement of P/F ratio, clinical requirement of RRT, and adverse events).

Conclusions:

Although this treatment combination reduced the number of days for which mechanical ventilation was required, it did not reduce the all-cause mortality at 30 days. In conclusion, the co-administration of albumin and diuretics may reduce hypotensive events and improve the P/F ratio at 24 hours.
Hub genes for early diagnosis and therapy of adamantinomatous craniopharyngioma
Authors: Zou Yang-Fan , Zhang Shu-Yuan , Li Li-Weng , Jing Kai , Xia Liang , Sun Cai-Xing , Wu Bin
Published: September 2022

Background:

Adamantinomatous craniopharyngioma (ACP) is a subtype of craniopharyngioma, a neoplastic disease with a benign pathological phenotype but a poor prognosis in the sellar region. The disease has been considered the most common congenital tumor in the skull. Therefore, this article aims to identify hub genes that might serve as genetic markers of diagnosis, treatment, and prognosis of ACP.

Methods:

The procedure of this research includes the acquisition of public data, identification and functional annotation of differentially expressed genes (DEGs), construction and analysis of protein-protein interaction network, and the mining and analysis of hub genes by Spearman-rho test, multivariable linear regression, and receiver operator characteristic curve analysis. Quantitative real-time polymerase chain reaction was used to detect the level of mRNA of relative genes.

Results:

Among 2 datasets, a total of 703 DEGs were identified, mainly enriched in chemical synaptic transmission, cell adhesion, odontogenesis of the dentin-containing tooth, cell junction, extracellular region, extracellular space, structural molecule activity, and structural constituent of cytoskeleton. The protein-protein interaction network was composed of 4379 edges and 589 nodes. Its significant module had 10 hub genes, and SYN1, SYP, and GRIA2 were significantly down-regulated with ACP.

Conclusion:

In a word, we find out the DEGs between ACP patients and standard samples, which are likely to play an essential role in the development of ACP. At the same time, these DEGs are of great value in tumors’ diagnosis and targeted therapy and could even be mined as biological molecular targets for diagnosing and treating ACP patients.
Serum albumin, cognitive function, motor impairment, and survival prognosis in Parkinson disease
Authors: Sun Shujun , Wen Yiyong , Li Yandeng
Published: September 2022

The role of albumin in Parkinson disease (PD) is not well understood, our study will investigate the association between the serum albumin level and risk of dementia, motor impairment, as well as survival outcome in PD. Data were obtained from the publicly available dataset in the DRYAD database (https://datadryad.org/). The original prospective study enrolled patients with PD from a single center in Japan between March 2004 and November 2007. Due to missing values, 242 and 274 participants were included in the study, in which we aimed to, respectively, analyze the relationship between serum albumin and cognitive function as well as motor impairment; additionally, 264 participants were included to assess the association between baseline serum albumin levels and risk of PD-related death with a median follow-up of 5.24 years. Compared to patients of the low tertile of albumin levels, Mini-Mental State Examination (MMSE) of patients of middle tertile increased 2.09 [95% confidence interval (CI) (0.45, 3.73), P = .013], independent of age, sex, PD duration, modified Hoehn-Yahr (mHY) stage, C-reactive protein (CRP) level, and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Further analysis revealed a positive curvilinear association between albumin and MMSE, with cutoff values of 3.9. As concentration serum albumin increased, the risk of severe motor impairment was grown [odds ratio (OR) 0.34 (95% CI 0.14,0.8), P = .013] after adjustment by age, sex, PD duration, MMSE scores, CRP level, and use of NSAIDs. Albumin levels increased per unit of mg/dL, and the risk of PD-related death reduced 0.74-fold with 95% CI (0.15, 0.86) (P = .021), independent of age, sex, PD disease duration, mHY stage, CRP levels, use of NSAIDs, and MMSE. Higher serum albumin levels were significantly association with the better cognitive function when albumin was <3.9 mg/dL, and played a protective role in severe motor impairment and PD-related death.
Extragastric recurrence in patients who underwent surgical resection of stage I gastric cancer: Incidence, risk factors, and value of abdominal computed tomography as a postoperative surveillance method
Authors: Jin Kim Su , Kim Tae Un , Woong Choi Cheol , Gon Ryu Dae
Published: September 2022

Extragastric recurrence after radical resection of stage I gastric cancer is very rare. We investigated the incidence of extragastric recurrence and risk factors in patients who underwent surgical resection of stage I gastric cancer and evaluated the value of abdominal CT as a surveillance tool. This retrospective study enrolled 914 patients with stage I gastric cancer who underwent surgical resection at a single tertiary hospital. We investigated extragastric recurrence during the follow-up period, and disease-free survival (DFS) was assessed. Over a median follow-up period of 39 months, the overall incidence of extragastric recurrence was 2.2% (20/914). Risk factors for extragastric recurrence included deep submucosal invasion (SM2-3), muscularis propria invasion, and lymph node metastasis (hazard ratio [HR]=10.37, 28.101, and 6.843; P = .028, .002, and .001, respectively). Based on the number of risk factors, patients were stratified into 3 subgroups: low-risk (pT1aN0, pT1b(SM1)N0, 496/914), moderate-risk (pT1aN1, pT1b(SM1)N1, pT1b(SM2-3)N0, pT2N0, 369/914), and high-risk (pT1b(SM2-3)N1, 49/914). DFS was significantly longer in the low-risk group, followed by the moderate-risk and high-risk groups. We propose that postoperative CT surveillance should be omitted for stage 1A cases involving the mucosa and SM1 because of the extreme rarity of extragastric recurrence.
Effect of enterovirus 71 vaccination on the epidemiological characteristics and etiology in hospitalized children with hand-foot-and-mouth disease: A retrospective study from a tertiary children’s hospital
Authors: Sun Jing , Li Yuanyuan , Yang Zhi , Fang Qingfeng , Chen Biquan
Published: September 2022

Enterovirus 71 (EV71) vaccine for hand-foot-and-mouth disease (HFMD) prevention has been available for several years. However, as a new vaccine, the impact of EV71 vaccination on the epidemiology and etiology of HFMD is currently unclear. The purpose of this study was to compare and analyze the changes of epidemiological characteristics and etiology of HFMD patients after the introduction of EV71 vaccine. The data of hospitalized children with HFMD from 2014 to 2020 were collected from the case record department of a tertiary children hospital of Anhui Province. The changes of epidemiological characteristics, time distribution, disease severity and enterovirus serotypes in hospitalized children were analyzed. A total of 7373 cases of HFMD were reported during 2014 to 2020, including 634 (8.6%) severe cases. The number of cases reached the peak in 2016 (n = 1783) and decreased gradually after EV71 vaccination. The results of etiological test showed the positive rate was 80.5%, in which EV71 accounted for 1599 (21.7%) and CV-A16 accounted for 1028 (13.9%) respectively. The number of patients showed a bimodal distribution throughout the year, which were April to June and October to November. The age distribution changed significantly following the introduction of EV71 vaccine. The proportion of 1-year-old group of post-vaccination was significantly higher than that of pre-vaccination (61.9% vs 50.8%, P < .001). The proportion of HFMD caused by EV71 and severe cases decreased significantly after the vaccination (P < .001 for both). While the comparison of epidemiological characteristics and enterovirus serotypes between unvaccinated and vaccinated cases during 2017 to 2020 showed no significant difference. The dominant enterovirus serotypes of hospitalized HFMD changed significantly after the introduction of EV71 vaccine. The proportion of severe cases decreased significantly after the vaccination, but EV71 was still a major pathogen in patients with severe HFMD. More age-appropriate children are recommended to get vaccinated to establish stronger herd immunity in the population.
New insight into the current study of high tibial osteotomy: A bibliometric analysis
Authors: Wei Cong , Xie Wenqing , Zhang Wenchao , Tang Ning , Su Yang , Jiang Buchan , Walschot Lucas H. , Xu Haijun , Li Yusheng , Huang Tianlong
Published: September 2022

Background:

To analyze global trends in focus and funding of research related to high tibial osteotomy (HTO) and to identify the 100 most cited articles in this field.

Methods:

A Web of Science search was used to identify HTO publications in English-language scientific journals from January 1967 till February 3th, 2021. Results were filtered to the 100 most cited articles by reading the abstract or full-text paper. Information of these articles was recorded for further analysis. The 10 top-cited articles during the last 5 years and the 10 top-cited articles about HTO ranked by average citations per year were selected to predict research trends.

Results:

In all, 48 out of the 100 top-cited articles were published between 2000 and 2010. The United States of America was the primary contributor (n = 29) followed by Germany (n = 17) and Japan (n = 11). The total number of citations per article ranged from 65 to 563, median 108, mean 135 (standard deviation = 84). The American Journal of Bone and Joint Surgery accounted for 23 out of the 100 top-cited articles. Koshino T was the most cited author (603 citations). The most frequently highlighted study theme was prognostic research. Patient-based clinical research was the dominant study design (85%). The majority of articles (48 out of 100) were level IV evidence with a mean of 141 (standard deviation = 97) citations. Top-cited articles in the last 5 years focused on open wedge osteotomy.

Conclusion:

Technical optimization of open wedge osteotomy has emerged as the main area of research in HTO. More specifically, recent publications focus on the surgical technology, cartilage repair and new fixation devices. Besides, papers with a high level of evidence are needed for the development of HTO.
Use of low molecular weight heparin and hemoglobin fall in COVID-19 patients: A STROBE-compliant study
Authors: Hong Ping-Yang , Huang Mao-Hong , Hu An-Ke , Lai Yan-Ting , Zeng Hui-Qing , Zhang Xiao-Bin
Published: September 2022

In patients with coronavirus disease 2019 (COVID-19), anticoagulation was suggested as a mitigating strategy. However, little research has been conducted on the adverse consequences of anticoagulant medication. This study aimed to investigate the adverse effect of low molecular weight heparin (LMWH) on hemoglobin fall in COVID-19 treatment. The electronic medical records of COVID-19 patients with pneumonia were collected (including clinical characteristics, vaccination status, complete blood count, coagulation profile, inflammatory cytokines, serum biochemical indicators, and computerized tomography imaging score). Whether they received LMWH, patients were divided into the LMWH group and the control group. Count data were represented as frequency distribution, and a 2-tailed test was used to compare the 2 groups. Spearman rank correlation was used to evaluate the interrelation between changes in hemoglobin and LMWH. The confounding factors were excluded by logistic regression analysis. A total of 179 COVID-19 pneumonia patients were enrolled (81 in the LMWH group and 98 in the control group). The change in hemoglobin was −6.0g/L (IQR −10.8 to 1.0) in the LMWH group and −2.0g/L (IQR −7.0 to 4.0) in the control group (P < .001, between-group difference, −5.0 g/L; 95% confidence interval, −7.0 to −3.0, calculated with the use of the Mann–Whitney U test and the Hodges–Lehmann estimate of confidence intervals for pseudo-medians). The results of multivariate regression analysis showed that after adjusting for confounding factors, LMWH use was not associated with a decrease in hemoglobin (P > .05). In nonsevere COVID-19 patients with pneumonia, the preventive use of LMWH did not lower hemoglobin.
Relationship between mental disorders, psychotropic drugs, and constipation in psychiatric outpatients
Authors: Akasaka Kuni , Akasaka Fumi , Akasaka Tadashi , Okada Kazutake , Sadahiro Sotaro
Published: September 2022

Constipation has been reported to be more common in patients with mental disorders than in the general population. However, its relationships with psychiatric diagnosis, medication, age, and sex have not been fully identified.

A total of 875 patients from the outpatient department were included in the study. As a retrospective observational study, the psychiatric diagnoses and psychotropic medications were examined based on the medical charts. Fecal conditions, including problems with defecation, abdominal pain, sense of incomplete evacuation, use of laxatives, frequency of defecation, and stool characteristics according to the Bristol Scale, were investigated.

The study included 368 males and 507 females, with median ages of 48 and 52 years, respectively. The most common psychiatric diagnoses were depressive disorders (33%), followed by anxiety disorders (19%). Females had significantly higher rates of problems with defecation and laxative use than males (P < .001, P < .0001, respectively). The frequency of laxative use increased significantly with age (P < .0001). The multivariate analyses revealed the close relationship between hypnotics and problems of defecation and that between hypnotics, antipsychotics, and laxative use.

In psychiatric outpatients, females had significantly higher rates of problems with defecation and laxative use than males. The use of laxatives significantly increased with age. Problems with defecation were significantly more common in patients taking hypnotics and laxative use was significantly more common in patients taking hypnotics and antipsychotics.
Bibliometric analysis of research relating to the use of herbal medicine for rheumatoid arthritis between 1991 to 2021
Authors: Kang Do-Young , Kim Hyungsuk , Kim Koh-Woon , Chung Won-Seok
Published: September 2022

Background:

Rheumatoid arthritis (RA) is an inflammatory autoimmune disease, which is well known for its poor symptoms, and the incidence is increasing worldwide. Although conventional medicines are practiced initially, patients often move or accompany to complementary and alternative medicines for better outcomes. Herbal medications, one of traditional medicinal approach, are widely used in clinical conditions. However, no research has broadly reviewed the current research trends regarding the scope of herbal medicines in RA. The aim of this study was to conduct a bibliometric analysis of applications of herbal medicine for RA from 1991 to the present

Methods:

We retrieved literature on herbal medicine for RA from the Web of Science database from 1991 to 2021. The VOSviewer program was used to analyze keywords, authors, countries, and organizations through visual knowledge mapping to assess the research hotspots and trends.

Results:

A total of 516 articles were included in the analysis, which showed an increasing trend in the number of publications over time. Four clusters were identified from the keyword analysis: complementary and alternative medicine cluster, mechanism of the pain cluster, control for the pain cluster, and recent research trend cluster. People’s Republic of China published 250 articles, which was the greatest number of publications, followed by the United States of America (82 articles) and South Korea (52 articles). Furthermore, Moudgil, KD of the University of Maryland published 15 articles about the mechanism of herbal medicine on autoimmune arthritis and their interaction with various drugs. Lu, AP of the Hong Kong Baptist University published 14 articles about herbal medicine interactions. On an institutional level, the China Academy of Chinese Medical Science published 33 articles, followed by the Hong Kong Baptist University and the University of Maryland with 27 and 20 articles, respectively. Clusters of organizations from the People’s Republic of China and the United States of America revealed higher average citations for earlier average publication years.

Conclusions:

This bibliometric study identified trends in herbal medicine for RA from 1991 to 2021, which may guide the hot topics and future directions in this research field.
Assessment of information on YouTube on the effect of acupuncture in patients with COVID-19: A cross-sectional study
Authors: Chang Min Cheol , Choo Yoo Jin
Published: September 2022

Medical-related information rapidly spreads throughout the internet. However, these types of information often contain inaccurate information, which can lead to harmful misconceptions. In this study, we evaluated the reliability, quality, and accuracy of videos uploaded on YouTube that harbor claims on the effects of acupuncture on COVID-19 treatment. This is a cross-sectional study. Videos uploaded on YouTube up to February 17, 2022, were searched, and the keywords used were as follows: “acupuncture,” “coronavirus,” “COVID 19,” “COVID-19,” “Corona,” “COVID,” and “SARSCoV2.” The top 50 videos in English were viewed and evaluated. The reliability of the videos was evaluated using the modified DISCERN scale, the content-quality was evaluated using the Global Quality Scale. The accuracy of the information in each video was evaluated as well. Of the 50 videos, only 8% were found to be reliable and 64% were of poor quality. Additionally, 98% of the videos were misleading. The mean modified DISCERN scores was 1.72 and the mean Global Quality Scale score was 2.06. Despite the videos being made by experts, their reliability, content-quality, and accuracy were found to be low. The spread of inaccurate information may result in the use of inappropriate and potentially harmful treatment methods for patients. Videos that contain medical information should be produced based on verified scientific evidence.
Portal vein aneurysm combined with intrahepatic portosystemic venous shunt diagnosed by multimodal imaging techniques: A case report
Authors: Liu Xin , Liu Bingmu , Guo Liqun
Published: September 2022

Introduction:

Portal vein aneurysms (PVA) and intrahepatic portosystemic venous shunts are rarely diagnosed clinically.

Patient Concerns:

A 75-year-old female was admitted to our hospital for evaluation of significant weight loss, diabetes, and an irregularly shaped cystic lesion in the left lateral lobe of the liver.

Diagnosis:

The patient was diagnosed with a portal vein aneurysm combined with an intrahepatic portosystemic venous shunt using multiple imaging techniques.

Interventions:

The patient had no relevant clinical symptoms of PVA with concurrent intrahepatic portosystemic venous shunt; hence, no interventions were performed. Ultrasonography was suggested to be performed every 3 months.

Outcomes:

The patient did not visit the hospital after discharge; however, 4 telephonic follow-up evaluations showed that the patient was well.

Lessons:

Multimodal imaging techniques should be used to evaluate the source of blood flow, presence or absence of shunts, and the course, number, and location of the shunts to prevent misdiagnosis of this disease.
The usefulness, reliability, and quality of YouTube video clips on congenital muscular torticollis: A STROBE compliant study
Authors: Jeong Kil-Yong , Lee Hyun Jung , Yim Shin-Young
Published: September 2022

This study aimed to evaluate the usefulness, reliability, quality, and related characteristics of YouTube video clips on congenital muscular torticollis (CMT). This cross-sectional study analyzed 47 YouTube video clips on CMT. They were classified as either useful or misleading by 2 rehabilitation doctors. The modified DISCERN tool and the Global Quality Scale (GQS) were used to evaluate their reliability and quality. An analysis was conducted using the characteristics, such as presenters, ownership of YouTube channel accounts, countries, contents, and the video popularity. Of the 47 YouTube video clips, 8 (17%) were evaluated as misleading, which indicated that they included at least one scientifically unproven piece of information on CMT or more. They were less reliable and of lower quality than the useful video clips. The video clips presented by healthcare professionals were more useful compared to those presented by others (P = .015). However, the video popularity was not related to its usefulness. The reliability and quality (3.70 ± 0.82 vs 0.75 ± 0.50 and 2.95 ± 1.21 vs 1.50 ± 1.00) assessed by the modified DISCERN tool and GQS, respectively, were significantly higher in the video clips presented by healthcare professionals compared to those presented by others. There were misleading YouTube video clips on CMT. Video clips presented by healthcare professionals could be more useful, reliable, and of better quality. The popularity of the video clips does not indicate more usefulness, reliability, and better quality. YouTube viewers should be aware of these findings. We recommend that the viewers preferentially choose video clips on CMT presented by healthcare professionals, not by the video popularity.
Distinguishing pancreatic solid serous cystadenomas from nonfunctional pancreatic neuroendocrine tumors by computed tomography: A propensity score analysis
Authors: Fang Xu , Jiang Hui , Cao Kai , Li Jing , Liu Fang , Wang Li , Lu Jianping , Shao Chengwei , Bian Yun
Published: September 2022

This study aims to evaluate the utility of calculated computed tomography (CT) attenuation value ratio (AVR) and enhancement pattern in distinguishing pancreatic solid serous cystadenomas (SCAs) from nonfunctional pancreatic neuroendocrine tumors (NF-pNETs). A total of 142 consecutive patients with 22 solid SCAs and 120 NF-pNETs confirmed by pathology were included in this retrospective study. All patients underwent preoperative contrast-enhanced CT and were categorized into 2 groups, solid SCA and NF-pNET groups. Patients with NF-pNETs were matched to patients with solid SCAs via propensity scores. AVR was measured and defined as: attenuation value of tumor/attenuation value of normal pancreas. AVR and enhancement pattern performance were assessed according to the discriminative abilities of patients. After matching, 29 patients were allocated to the NF-pNET group. Before matching, sex, age, and the peak enhanced value phase were significantly different between solid SCA and NF-pNET patients (P < .05). After matching, no significant difference was observed between both groups (P > .05). Solid SCAs AVRs were significantly smaller than NF-pNETs AVRs in all unenhanced, arterial, portal venous, and delayed phases (P < .05). Solid SCAs showed significantly more wash-in and wash-out enhancement patterns than NF-pNETs (P < .05). For unenhanced, arterial, portal venous, and delayed phases, and enhancement pattern, the area under the curve (AUC) values were 0.96, 0.72, 0.80, 0.85, and 0.86, respectively. Low AVR on unenhanced CT and wash-in and wash-out enhancement patterns were useful for differentiating solid SCAs from NF-pNETs and may be useful for clinical decisions, a clearer opinion will be formed with further studies to be conducted with larger patient numbers.
Living liver donor hilar anatomical variations and impact of variant anatomy on transplant outcomes
Authors: Kirimker Elvan Onur , Kologlu Meltem , Celik Suleyman Utku , Ustuner Evren , Kul Melahat , Oz Digdem Kuru , Karayalcin Mehmet Kaan , Balci Deniz
Published: September 2022

Donor anatomy is an essential part of donor selection and operative planning in living donor liver transplantation. In this study, variations of hilar structures, and the effects of variant anatomy on donor and recipient outcomes were evaluated. Living donor liver transplantations in a single center between January 2013 and December 2020 were retrospectively reviewed. In total, 203 liver transplantations were analyzed. Type 1 arterial anatomy, type 1 portal vein anatomy and type 1 bile duct anatomy were observed in 144 (70.9%), 173 (85.2%), and 129 (63.5%) donors, respectively. Variant biliary anatomy was observed more frequent in donors with variant portal vein branching than in those with type 1 portal anatomy (60.0% vs 32.3%, P = .004). The overall survival rates calculated for each hilar structure were similar between recipients receiving grafts with type 1 anatomy and those receiving grafts with variant anatomy. When donors with variant anatomy and donors with type 1 anatomy were compared in terms of hilar structure, no significant difference was observed in the frequency of complications and the frequency of serious complications. Biliary variations are more common in individuals with variant portal vein anatomy. Donor anatomic variations are not risk factors for inferior results of recipient survival or donor morbidity.
Effects of high-quality nursing care on quality of life, survival, and recurrence in patients with advanced nonsmall cell lung cancer
Authors: Wang Minghuan , Sun Yang , Zhang Meihui , Yu Renzhi , Fu Jing
Published: September 2022

Background:

Postoperative nursing can improve the quality of life (QoL) and functional prognosis for lung cancer patients. The purpose of this study was to evaluate the effects of high-quality nursing on inflammation and prognosis in postoperative patients with advanced nonsmall cell lung cancer (NSCLC).

Methods:

A total of 372 patients with NSCLC were enrolled between the May 2014 and June 2016. Patients were randomly received high-quality nursing (n = 192) or normal nursing (n = 180). Symptom management, QoL, hospital stay, inflammatory score, survival time, recurrence rate, symptoms, anxiety, depression scale and psychological distress were assessed at baseline and 5-year follow up.

Results:

High-quality nursing significantly shortened hospital stay, improved postoperative inflammation, symptom management, QoL compared to patients received normal nursing. Compare with normal nursing, high-quality nursing decreased anxiety, depression scale and psychological distress for postoperative patients with advanced NSCLC. Outcomes showed that high-quality nursing increased the survival time and decreased recurrence rate for postoperative patients with advanced NSCLC.

Conclusion:

In conclusion, data in the current study indicate that high-quality nursing can decrease inflammation and improve prognosis for the postoperative patients with NSCLC.
Genetic polymorphism of pleiotrophin is associated with pain experience in Japanese adults: Case-control study
Authors: Saita Kosuke , Sumitani Masahiko , Nishizawa Daisuke , Tamura Takashi , Ikeda Kazutaka , Wakai Kenji , Sudo Yoshika , Abe Hiroaki , Otonari Jun , Ikezaki Hiroaki , Takeuchi Kenji , Hishida Asahi , Tanaka Keitaro , Shimanoe Chisato , Takezaki Toshiro , Ibusuki Rie , Oze Isao , Ito Hidemi , Ozaki Etsuko , Matsui Daisuke , Nakamura Yohko , Kusakabe Miho , Suzuki Sadao , Nakagawa-Senda Hiroko , Arisawa Kokichi , Katsuura-Kamano Sakurako , Kuriki Kiyonori , Kita Yoshikuni , Nakamura Yasuyuki , Momozawa Yukihide , Uchida Kanji
Published: September 2022

Genetic factors play a role in individual differences in pain experience. Here, we performed a genome-wide association study (GWAS) to identify novel loci regulating pain processing. We conducted a 2-stage GWAS and the candidate single-nucleotide polymorphisms (SNPs) association study on pain experience using an exploratory cohort of patients with cancer pain. The confirmatory cohort comprised of participants from the general population with and without habitual use of analgesic medication. In the exploratory cohort, we evaluated pain intensity using a numerical rating scale, recorded daily opioid dosages, and calculated pain reduction rate. In the confirmatory cohort, pain experience was defined as habitual nonsteroidal anti-inflammatory drug usage. Using linear regression models, we identified candidate SNP in the exploratory samples, and tested the association between phenotype and experienced pain in the confirmatory samples. We found 1 novel SNP (rs11764598)—located on the gene encoding for pleiotrophin on chromosome 7—that passed the genome-wide suggestive significance at 20% false discovery rate (FDR) correction in the exploratory samples of patients with cancer pain (P = 1.31 × 10-7, FDR = 0.101). We confirmed its significant association with daily analgesic usage in the confirmatory cohort (P = .028), although the minor allele affected pain experience in an opposite manner. We identified a novel genetic variant associated with pain experience. Further studies are required to validate the role of pleiotrophin in pain processing.
Radiation dose and image quality of CT coronary angiography in patients with high heart rate or irregular heart rhythm using a 16-cm wide detector CT scanner
Authors: Ondrejkovic Marian , Salat Dusan , Cambal Daniel , Klepanec Andrej
Published: September 2022

Aim of the study was to evaluate the effect of high and irregular heart rate on the image quality and on the radiation exposure using a 256-row, 16-cm wide detector computed tomography (CT) system. Between March and December 2019, 349 patients undergoing CT coronary angiography (CTCA) were prospectively enrolled. Patients were divided into 2 study groups; Group 1 included patients with a regular heart rate of ≤70 bpm, while Group 2 included patients with an irregular heart rhythm or heart rate of >70 bpm. In all patients, image quality score and radiation dose were analyzed and recorded. In Group 1, there were a total of 195 patients, while in Group 2, there were 154 patients. Of the 349 patients, 299 of them had a regular heart rhythm (85.7%) and 50 (14.3%) had an irregular heart rhythm. Mean heart rate during scanning was 59 ± 7 bpm in Group 1 and 80 ± 12 bpm in Group 2. Mean effective dose of CTCA in Group 1 (1.2 ± 0.8 mSv) was lower than in Group 2 (1.9 ± 1.2 mSv, P < .001). Mean image quality (Likert score) of Group 1 was significantly higher than in Group 2 (4.1 vs 3.4, P < .001). CT scanner with 16-cm wide detector enables low-radiation exposure during CTCA even at high heart rate or irregular heart rhythm. Good CTCA image quality and low dose are related to low heart rate.
Identification of a novel ubiquitination related gene signature for patients with breast cancer
Authors: Zheng Yuan , Lu Wenliang , Chen Bo , Zhao Kankan
Published: September 2022

Ubiquitination related genes (URGs) are important biomarkers and therapeutic targets in cancer. However, URG prognostic prediction models have not been established in breast cancer (BC) before. Our study aimed to identify URGs to serve as potential prognostic indicators in patients with BC.The URGs were downloaded from the ubiquitin and ubiquitin-like conjugation database. GSE42568 and The Cancer Genome Atlas were exploited to screen differentially expressed URGs in BC. The univariate Cox proportional hazards regression analysis, least absolute shrinkage and selection operator analysis, and multivariate Cox proportional hazards regression analysis were employed to construct multi-URG signature in the training set (GSE42568). Kaplan–Meier curve and log-rank method analysis, and ROC curve were applied to validate the predictive ability of the multi-URG signature in BC. Next, we validated the signature in test set (GSE20685). Finally, we performed GSEA analysis to explore the mechanism.We developed a 4-URG (CDC20, PCGF2, UBE2S, and SOCS2) signature with good performance for patients with BC. According to this signature, BC patients can be classified into a high-risk and a low-risk group with significantly different overall survival. The predictive ability of this signature was favorable in the test set. Univariate and multivariate Cox regression analysis showed that the 4-URG signature was independent risk factor for BC patients. GSEA analysis showed that the 4-URG signature may related to the function of DNA replication, DNA repair, and cell cycle.Our study developed a novel 4-URG signature as a potential indicator for BC.
Outcomes between non-IVF and IVF treatment after laparoscopic conservative surgery of advanced endometriosis with Endometriosis Fertility Index score >3
Authors: Demir Emine , Soyman Zeynep , Kelekci Sefa
Published: September 2022

Surgical excision of advanced endometriosis has been demonstrated to improve women’s pain symptoms and quality of life in women in randomized placebo-controlled trials, but there is no strong evidence regarding the live birth rate. The revised American Fertility Society (r-AFS) classification for endometriosis has a limited predictive ability for fertility outcomes after surgery; therefore, EFI scoring has been advised for predicting conception after endometriosis surgery. No randomized controlled trials have investigated fertility outcomes in patients with advanced endometriosis after surgery. This study aimed to determine the outcomes of in vitro fertilization (IVF) or non-IVF treatments after conservative surgery for advanced endometriosis in patients with good prognosis Endometriosis Fertility Index (EFI) scores (>3). This prospective cohort study was conducted between April 2014 and April 2019 at a tertiary research hospital. In total, 113 women with suspected preoperative advanced endometriosis were enrolled in this study. A total of 90 women with advanced endometriosis underwent laparoscopic surgery. Fourteen patients with EFI score of ≤3 and 3 of them who had bilateral tubal occlusion were also excluded. Seventy-three women were included in this study. The remaining 30 women in the non-IVF group and 32 women in the IVF group were analyzed. The main outcome measures were cumulative pregnancy rates and live birth rates in both groups. Women who underwent IVF treatment were older than women (30 ± 3.41) who had non-IVF treatment (26.5 ± 3.07) after laparoscopic surgery (P < .001). The remaining baseline characteristics of the patients in both groups were similar. Clinical pregnancy, abortion, and live birth rates were similar in both the groups after 36 months of follow-up. This study demonstrated that cumulative pregnancy and live birth rates were similar to those of non-IVF or IVF treatments after conservative surgery for advanced endometriosis, if patients had good prognosis EFI scores. Furthermore, non-IVF treatments resulted in nearly the same clinical pregnancy results as IVF treatment within 1 year after surgery.
Effects of carotid artery stenting on cognitive impairment in patients with severe symptomatic carotid artery stenosis
Authors: Gao Hui-Li , Han Bing-Sha , Zhang Kun , Wang Zi-Liang , Gao Bu-Lang , Li Tian-Xiao , Zhu Liang-Fu
Published: September 2022

The effect of carotid artery stenting and medication on improvement of cognitive function in patients with severe symptomatic carotid artery stenosis is unknown. To investigate the effect of stenting compared with medication alone for severe carotid atherosclerotic stenosis on cognitive impairment. Patients with carotid stenosis and cognitive impairment were prospectively randomly divided into 2 groups of stenting or medication alone. Cognitive function was evaluated with the Montreal cognitive assessment (MoCA), Mini-Mental State Examination, and Barthel Index of Activities of Daily Living (BI). Continuous data in normal distribution were tested with the t-test but with the Mann-Whitney U test if not in normal distribution. Categorical data were presented as frequency and percentages and tested with the Fisher exact test. A P value < .05 was regarded as statistical significant. Carotid artery stenting was successfully performed in all patients (100%) in the stenting group. Compared with before treatment, the Mini-Mental State Examination, MoCA and BI scores at 6 months in the medication alone group and at 1, 3, and 6 months in the stenting group were significantly (P < .005) improved. The stenting group had significantly (P < .05) better scores than the medication alone group at the same time. At 6-month follow-up, the visuospatial/executive functions (3.69 ± 1.42 vs 2.42 ± 1.23), attention (5.24 ± 1.52 vs 3.63 ± 1.47), and language (2.64 ± 0.71 vs 1.96 ± 0.69) were significantly (P < .05) improved in the stenting group compared with the medication alone group. Carotid artery stenting may significantly improve cognitive impairment and neurological function compared with medication alone in patients with severe carotid atherosclerotic stenosis concurrent with cognitive impairment.
Serologic versus molecular testing for screening for hepatitis C virus infection in patients with hematologic malignancies
Authors: Torres Harrys A. , Angelidakis Georgios , Jiang Ying , Economides Minas , Mustafayev Khalis , Yibirin Marcel , Orlowski Robert , Champlin Richard , Verstovsek Srdan , Raad Issam
Published: September 2022

Testing for antibody against hepatitis C virus (anti-HCV) is a low-cost diagnostic method worldwide; however, an optimal screening test for HCV in patients with cancer has not been established. We sought to identify an appropriate screening test for HCV infection in patients with hematologic malignancies and/or hematopoietic cell transplants (HCT). Patients in our center were simultaneously screened using serological (anti-HCV) and molecular (HCV RNA) assays (February 2019–November 2019).

In total, 214 patients were enrolled in this study. Three patients (1.4%) were positive for anti-HCV, and 2 (0.9%) were positive for HCV RNA. The overall percentage agreement was 99.5% (95% CI: 97.4–99.9). There were no cases of seronegative HCV virus infection. The positive percentage agreement was 66.7% (95% CI: 20.8–93.9), and the negative percentage agreement was 100.0% (95% CI: 98.2–100.0). Cohen kappa coefficient was 0.80 (95% CI: 0.41–1.00, P < .0001).

The diagnostic yield of screening for chronic HCV infection in patients with cancer is similar for serologic and molecular testing.
Designing with relaxed skin tension line in perforator-based island flap for sacral sore reconstruction: A STROBE-compliant observational study
Authors: Kwon Hyeokdong , Ahn Chang Hwan , Kim Sunje , Kim Joo-Hak , Kyung Hyun Woo , Song Seung Han , Oh Sang-Ha , Yang Ho Jik , Ha Yooseok
Published: September 2022

Many various types of operative techniques have been performed used to treat make-up for sacral defects. Perforator-based flaps with flap transposition, but achieving an optimal flap design and tension-free flap closure without skeletonizing the perforator requires a great deal of clinical experience. In this study, we demonstrate perforator selection based on considerations of the relaxed skin tension line (RSTL), which has proven to be a suitable method of achieving an efficient flap design that enables primary closure.

Twenty-five perforator-based flap procedures were performed on 25 patients at a single institution from February 2018 to January 2021. The medical records of patients were retrospectively reviewed.

Twenty-three flaps survived completely. Two flaps developed partial tip necrosis but recovered after secondary healing, and 1 patient developed temporary congestion, which resolved spontaneously. No recipient or donor site recurrence or dehiscence was identified during follow-up.

We report our clinical experiences of perforator-based flap use in the sacral region. When selecting an appropriate perforating vessel, 2 important points should be considered, that is, a flap long axis parallel to RSTLs and defect shape. According to the method presented in this paper, perforator-based flaps can be transposed safely and easily with few complications and serve as useful practice models to cover sacral defects.
Radiological osteoarthritic knee joint changes in high school and collegiate sumo wrestlers: The observational study
Authors: Nakagawa Yasuaki , Mukai Shogo , Minami Kazufumi , Hattori Yuji , Yamagishi Hiroya , Nakamura Ryota
Published: September 2022

We examined the effects of sumo on their knee joints, and investigated the relationship between radiological changes and knee joints symptoms, and the relationship between knee radiological changes and the physical characteristics of the wrestlers. Fifty-six high-school and 128 college freshman sumo wrestlers who belonged to the Japanese Sumo Federation. To evaluate radiological changes in the knee joints of high-school and college freshmen sumo wrestlers. They underwent routine radiographic examination of their knee joints and were instructed to answer a questionnaire regarding their knee symptoms as a medical check. The mean height, weight, body mass index (BMI), and sumo career/experience of the participants were 174.1 cm, 106.9 kg, 35.1 kg/m2, and 7.9 years, respectively. Twenty-five high-school (44.6%) and 54 collegiate (42.2%) sumo wrestlers had some knee symptoms, which was significantly associated with sumo career as a risk factor. Five high-school (8.9 %) and 18 collegiate (14.1 %) sumo wrestlers had joint space narrowing. Considering the relationship between knee symptoms and radiological changes, significant correlations between osteophyte formation and bony sclerosis and knee symptoms were observed. According to the Kellgren-Laurence (KL) classification, 7 high-school (12.5%) and 26 collegiate (20.3%) sumo wrestlers were grade 2, 3, or 4. The risk factors of degenerative radiographic changes in the knee joints of the participants were heavyweight, large BMI, and older age. The knee osteoarthritic changes had already appeared in 12.5% high-school sumo wrestlers at the admission.