bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancement of post-market surveillance of medical devices leveraging artificial intelligence: Infusion pumps case study
Authors: Merdović Nejra , Spahić Lemana , Hundur Madžida , Pokvić Lejla Gurbeta , Badnjević Almir
Published: December 2024

Background

Analysis of data from incident registries such as MAUDE has identified the need to improve surveillance and maintenance strategies for infusion pumps to enhance patient and healthcare staff safety.

Objective

The ultimate goal is to enhance infusion pump management strategies in healthcare facilities, thus transforming the current reactive approach to infusion pump management into a proactive and predictive one.

Method

This study utilized real data collected from 2015 to 2021 through the inspection of infusion pumps in Bosnia and Herzegovina. Inspections were conducted by the national laboratory in accordance with the Legal Metrology Framework, accredited to ISO 17020 standard. Out of 988 samples, 790 were used for model training, while 198 samples were set aside for validation (20% of the dataset). Various machine learning algorithms for binary classification of samples (pass/fail status) were considered, including Logistic Regression, Decision Tree, Random Forest, Naive Bayes, and Support Vector Machine. These algorithms were chosen for their ability to handle large datasets and potential for high prediction accuracy.

Results

Through detailed analysis of the achieved results, it was found that all applied machine learning methods yielded satisfactory results, with accuracy ranging from 0.98% to 1.0%, precision from 0.99% to 1%, sensitivity from 0.98% to 1.0%, and specificity from 0.87% to 1.0%. However, Decision Tree and Random Forest methods proved to be the best, both due to their maximum achieved values of accuracy, precision, sensitivity, and specificity, and due to result interpretability.

Conclusion

It has been established that machine learning methods are capable of identifying potential issues before they become critical, thus playing a crucial role in predicting the performance of infusion pumps, potentially enhancing the safety, reliability, and efficiency of healthcare delivery. Further research is needed to explore the potential application of machine learning algorithms in various healthcare domains and to address practical issues related to the implementation of these algorithms in real clinical settings.
Forecasting of hospitalizations for COVID-19: A hybrid intelligence approach for Disease X research
Authors: Mu He , Zhu Hongbing
Published: December 2024

The COVID-19 pandemic underscores the necessity for proactive measures against emerging diseases, epitomized by WHO's “ Disease X.” Among the myriad of indicators tracking COVID-19 progression, the count of hospitalized patients assumes a pivotal role. This metric facilitates timely responses from government agencies, enabling proactive allocation and management of medical resources. In this study, we introduce a novel hybrid intelligent approach, the EMD&LSTM-ARIMA model. This model integrates three techniques: Empirical Mode Decomposition (EMD) to decompose the data into intrinsic mode functions, Long Short-Term Memory (LSTM) neural network for capturing long-term dependencies and nonlinear relationships, and the Auto-Regressive Integrated Moving Average (ARIMA) model for handling linear trends and time series forecasting. We verify its high predictive power and utility through training and forecasting COVID-19 hospitalizations in the UK, Canada, Italy, and Japan. Our analysis reveals that all forecasted error rates remain below 10%, with Mean Absolute Percentage Error (MAPE) values obtained for these four countries as 2.30%, 3.33%, 1.63%, and 2.89%, respectively.
Clinical characteristics and prognostic analysis of patients with SMARCA4-deficient lung cancer
Authors: Xu Lingling , Xu Xianquan , Wu Pengfei , Ye Wei , Zhao Jieting , Yang Jingwen , Yao Yuanyuan , Chen Maoxi , Wang Xiaoyan , Wang Anbang , Fan Yanbo
Published: December 2024

Background

SMARCA4-deficient NSCLC is a rare type of tumor, accounting for approximately 10% of all NSCLC. It exhibits a weak response to conventional chemotherapy and has a poor prognosis, and lacks alterations in EGFR (epidermal growth factor receptor), ALK (anaplastic lymphoma kinase), and ROS1 (ROS proto-oncogene 1) genes Therefore, the mechanisms of SMARCA4 in NSCLC development urgently need to be explored to identify novel biomarkers and precise therapeutic strategies for this subtype.

Objective

The aim of this study was to understand the clinical characteristics of this special type of tumor and its response to different treatments.

Methods

We collected clinical data from 42 patients with SMARCA4-deficient NSCLC from July 2022 to January 2024, and analyzed their clinical features and survival state.

Results

The study included a total of 42 patients diagnosed with NSCLC and harboring SMARCA4 mutation. The majority of these patients were male with a median age of 67 years. Most patients presented at stage IV upon diagnosis with highly aggressive tumors characterized by high Ki-67 proliferation index values resulting in poor overall prognosis. Genetic testing revealed TP53 gene mutations to be most prevalent (21%), followed by KRAS mutations (13%). Patients receiving immunotherapy exhibited significantly longer median overall survival compared to those treated solely with chemotherapy. Targeted drug therapy demonstrated favorable effects in some patients.

Conclusion

NSCLC patients harboring SMARCA4 deficiency exhibit poor overall survival rates with a median overall survival time of 5.4 months. Immunotherapy may provide benefits for NSCLC patients with SMARCA4 deficiency.
Predictive value of mNUTRIC score for chronic critical illness in patients of sepsis complicated with ARDS
Authors: Ji Mingxia , Zhu Linlin , Chen Mengyan , Wang Yi , Qiu Weiyong , Zhang Ning
Published: December 2024

Background

To explore the predictive value of the modified NUTrition Risk in the Critically ill (mNUTRIC) for patients with sepsis and acute respiratory distress syndrome (ARDS) developing into chronic critical illness (CCI).

Methods

A retrospective observational study was conducted on 118 patients admitted to the Intensive Care Unit (ICU) of Yiwu Central Hospital from January 2020 to May 2022. Patients were categorized into two groups: CCI and rapid recovery (RAP), based on the occurrence of CCI. Age, gender, white blood cell count, C-reactive protein, albumin, serum creatinine, sequential organ failure assessment (SOFA), acute physiology and chronic health evaluation II (APACHE II), mNUTRIC score, ICU length of stay, mechanical ventilation duration, and continuous renal replacement therapy (CRRT) were compared between the two groups. The association between mNUTRIC and CCI in patients with sepsis complicated by ARDS was further examined using three models and multivariate logistic regression.The receiver operating characteristic (ROC) curve was utilized to analyze the predictive values of mNUTRIC score, SOFA score, and APACHE II score for predicting the occurrence of CCI in patients with sepsis complicated by ARDS.

Results

The age, mNUTRIC score, SOFA score, APACHE II score, ICU length of stay, mechanical ventilation duration, and CRRT ratio were significantly higher in the CCI group compared to the RAP group (all P < 0.05). Conversely, there were no statistically significant differences in white blood cell count, C-reactive protein, and albumin levels between the two groups (all P > 0.05). Multivariate logistic regression analysis identified the mNUTRIC score as an independent risk factor for CCI in patients with sepsis complicated by ARDS. The constructed models showed that the mNUTRIC score remained significant, while the SOFA score and APACHE II score did not.The area under the ROC curve analysis demonstrated that the mNUTRIC score had the highest AUC of 0.880, 95% Confidence Interval (CI): 0.808–0.933. The AUC for the SOFA score was 0.864, and for the APACHE II score was 0.825, all of which were statistically significant.

Conclusions

The mNUTRIC score is valuable in predicting the progression of sepsis combined with ARDS to CCI, and may even be superior to the SOFA score and APACHE II score.
Developing a method for predicting DNA nucleosomal sequences using deep learning
Authors: Alshammry Nizal
Published: December 2024

Background

Deep learning excels at processing raw data because it automatically extracts and classifies high-level features. Despite biology's low popularity in data analysis, incorporating computer technology can improve biological research.

Objective

To create a deep learning model that can identify nucleosomes from nucleotide sequences and to show that simpler models outperform more complicated ones in solving biological challenges.

Methods

A classifier was created utilising deep learning and machine learning approaches. The final model consists of two convolutional layers, one max pooling layer, two fully connected layers, and a dropout regularisation layer. This structure was chosen on the basis of the ‘less is frequently more’ approach, which emphasises simple design without large hidden layers.

Results

Experimental results show that deep learning methods, specifically deep neural networks, outperform typical machine learning algorithms for recognising nucleosomes. The simplified network architecture proved suitable without the requirement for numerous hidden neurons, resulting in effective network performance.

Conclusion

This study demonstrates that machine learning and other computational techniques may streamline and expedite the resolution of biological issues. The model helps identify nucleosomes and can be used in future research or labs. This study discusses the challenges of understanding and addressing simple biological problems with sophisticated computer technology and offers practical solutions for academic and economic sectors.
Discrete-time low-computation spacecraft attitude tracking control algorithm design considering actuation stiff constraints
Authors: Homaeinezhad Mohammad Reza , Nesaeian Mahdi
Published: December 2024

In this paper, the attitude tracking control of spacecraft has been investigated by taking into account the input saturation constraint and an oscillatory dynamic model for the actuators. A dual-mode control scheme is presented, which has a low computational cost. The command signals are calculated by defining power reaching laws and reference filtering method. For this purpose, a new projection operator is used to determine the best possible references based on system and actuator dynamics and saturation constraints. The Lyapunov stability of the closed-loop system as well as the convergence of the filtered references to the desired references were analyzed. The dual-mode-based command signals have been determined based on minimizing the one-step predictive attitude error by combining the two controllers. The efficacy of the algorithm for tracking control has been demonstrated through numerical simulations.
Numerical simulation and experimental study of the flow heat transfer characteristics of rectangular micro-grooved ultra-thin flat plate heat pipes
Authors: Huashan Su , Hong Chen , Kui Chen , Gang Wang
Published: December 2024

Ultra-thin flat heat pipes (UTFPs) effectively address the heat dissipation challenges of contemporary compact electronic devices, owing to their superior thermal conductivity and high stability in confined places. This paper established the VOF vapor-liquid two-phase flow model of the rectangular micro-grooved ultra-thin flat heat pipe (M-UTFP) and constructed a test platform for evaluating the heat transfer performance of heat pipes, incorporating various filling rates (30%, 35%, 40%, 45%) and heat fluxes (0.375 × 106 W/m2, 0.5 × 106 W/m2, 1 × 106 W/m2, 1.25 × 106 W/m2, 1.67 × 106 W/m2). The findings indicated that the phase transition initially transpires on the heating surface of the evaporation section, while the vapor on the wall of the condensing section generates a liquid film after condensation. The optimal liquid filling rate for the M-UTFP was 35%. A heat flux of 1 × 106 W/m2 maintained a stable temperature fluctuation in the evaporation section of the heat pipe, thereby enhancing heat transfer efficiency. These findings align with simulation results, offering data references and design principles for the development of ultra-thin electronic cooling systems, such as those used in chips, and extending the application scope of UTFPs.
Book review: Ethan Mollick. 2024. Co-intelligence: Living and Working with AI
Authors: Gautam Chitra
Published: December 2024

Ethan Mollick. 2024. Co-intelligence: Living and Working with AI. Portfolio/Penguin, ₹1,880; ISBN: 9780593716717
Stress, Resilience, Sexual Functioning and Quality of Life in Patients Undergoing Arthroplasty and Arthroscopy
Authors: V Sheshagiri , Thoralakki Ravitej Manjunath , P C Pradeep Kumar , J Shivananda Manohar
Published: December 2024

Background

In India, the incidence of orthopaedic conditions is significantly increasing, with 63 million people suffering from various orthopaedic issues, causing considerable distress to patients. This study aims to assess stress, resilience, sexual functioning, and quality of life in participants who underwent arthroplasty and arthroscopy surgery at baseline, one month, and three months.

Method

This comparative study utilised the Perceived Stress Scale (PSS), Connor-Davidson Resilience Scale, Sexual Function Scale, and the WHO Quality of Life Scale.

Results

The comparison between arthroscopy and arthroplasty reveals distinct patterns in stress, resilience, sexual functioning, and quality of life. For both procedures, stress levels were higher at baseline and one-month post-surgery but decreased by three months. Resilience scores improved consistently over time in both groups. However, sexual functioning and quality of life showed different trends: while sexual functioning initially decreased post-arthroscopy but improved by three months, arthroplasty participants generally experienced a more consistent improvement in both sexual functioning and quality of life from baseline through the follow-up periods.

Conclusion

The study showed that stress was significantly higher at baseline and one-month post-surgery. However, the trends in sexual functioning and quality of life differed between the two types of surgery. These findings highlight the need for tailored patient support and interventions based on the type of orthopaedic procedure performed.
Trends in access to clinical mental healthcare by very old people in Australia since ‘Better Access’ commenced in 2006
Authors: McKay Roderick , Morgan Shirlony , Lawn Sharon , McMahon OAM Janne
Published: December 2024

Objectives

To examine trends in access to mental healthcare by old and very old people since the commencement of Australia’s Better Access Initiative in 2006.

Methods

Descriptive analysis of changes in access by people aged 75–84 and over 85 using data analysed and published by the AIHW.

Results

Since the introduction of Better Access, rates of access to specialist inpatient and community mental healthcare have reduced for those aged 75 years and older. The reduction is greatest for those aged 85 and over; with a 21% fall in community care access, 54% fall in inpatient access, and Medicare-funded psychologists and clinical psychologists access failing to rise above 1%. Rates of admissions by those 85 and older to inpatient care without specialised mental healthcare have increased by 92%, with emergency department presentations with mental health problems increasing by 33% since 2014–2015.

Conclusions

The oldest people in Australia have missed most benefits from mental healthcare reforms. The contribution of these changes to high rates of mental illness on entering residential aged care, persistent high suicide rates in older men, and increased use of emergency departments and general hospital beds demands further inquiry and action.
Enhancing Rigor, Quality, and Patient Engagement in Qualitative Research: A Step-By-Step Guide to Applying Reflexive Thematic Analysis to the Experience-Based Co-Design Methodology
Authors: Wright Rebecca , Chapla Kavita , Booth Ashley , Nelson Katie E. , Peeler Anna , Swain Christy , Won Sarah , Wu David S.
Published: December 2024

Experience-based co-design (EBCD) is a qualitative form of participatory action research supported by a toolkit providing guidance and recommendations. The toolkit is intentionally non-prescriptive, allowing EBCD practitioners the freedom to flex the approach to cater to the needs of their specific populations and contexts. For less experienced researchers, the lack of specificity can be a challenge when navigating activities such as data analysis, particularly as wider literature provides limited insights to methods, processes, methodological critique, and lessons learned. Despite increasing use of EBCD, few practitioners publish details of their methods, processes, or decision-making for how they adapt EBCD for their studies, focusing more often on findings and outcomes. This can impact understanding and development of rigor in EBCD literature. In this methodology paper, we respond to this gap by providing a case example and step-by-step guide for application of reflexive thematic analysis to EBCD, with consideration of reflexivity, a conceptual framing for interpreting experiences, opportunities for greater participant involvement, and strengths and challenges of using reflexive thematic analysis within EBCD.
Enhancing Disability Research Through Participatory Video: Reflections on a Brazilian Study
Authors: Reichenberger Veronika , Penn-Kekana Loveday , Hameed Shaffa , Shakespeare Tom , Kuper Hannah
Published: December 2024

This paper explores the use of participatory video (PV) in a case study conducted in Arcoverde, Brazil, to address the call for greater participation of individuals with disabilities in health and social care planning and research. PV is grounded in similar concepts to the Disability Rights Movement’s principle of “Nothing About Us, Without Us” and serves as a potential collaborative tool for individuals with disabilities to shape their narratives and contribute to research. The study was part of a multi-methods research project on healthcare access, with the PV research focusing on primary healthcare in Arcoverde. The researcher emphasizes the action-oriented and community-based approach, to foster an inclusive environment through workshops, story circles, and video-making. Ethical considerations prioritize informed consent and identity protection. The results underscore the potential empowering impact of PV, fostering community awareness and practical awareness among participants. The discussion emphasizes the ethical considerations, challenges, and the need for reflexivity in participatory video research.
Access to Healthcare for Black Women in Alberta: An Interpersonal-Level Analysis of Barriers and Facilitators
Authors: Olukotun Mary , Karanja Lucy , Maduforo Aloysius , Renzaho Andre , Ospina Maria-Beatriz , Richter Solina , Tunde-Byass Modupe , Amodu Oluwakemi , Salami Bukola
Published: December 2024

Alberta is home to one of Canada’s fastest growing populations of Black people, driven by an influx of African immigrants to major metropolitan areas such as Edmonton and Calgary. As the Black population in Alberta continues to grow, it is crucial to the well-being of these communities that we understand their health service needs. Black women are a vulnerable group within the Black population due to inequities in social determinants of health such as access to healthcare. In Canada, little is known about the healthcare access experiences of Black women despite reported disparities in their health outcomes. As such, we undertook a qualitative study to examine access to health services for Black women in Alberta. Semi-structured interviews were completed with 30 Black women from Edmonton and Calgary. We applied intersectionality as an analytical framework to guide our understanding of how interconnected social processes shape Black women’s experiences of accessing healthcare. Following our thematic analysis, we identified two major barriers to healthcare access: patient–provider discordance and negative healthcare encounters. We identified two key facilitators: positive patient–provider dynamics and individual and social network strengths. Our findings suggest that Black women have distinct experiences of accessing the healthcare system which are best understood as a confluence of their race, gender, and other aspects of their personhood.
Assessing implications of occupational heat stress on the physiological and productive attributes of small-scale foundry workers in Northern India
Authors: Sharma Milap , Alam Md Sarfaraz , Sharma Kriti , Kataria Krishan Kumar
Published: December 2024

Background: Work operations involving intensive physical activities under hot stressful workplaces may impose substantial heat stress on the employed workforce, particularly in underdeveloped countries. Objective: The present study analysed occupational heat stress and its effect on workers’ well-being and productivity under distinct work environments in small-scale foundries in Northern India. Methods: Several dominant heat indices were used for evaluating the occupational heat risk exposure among foundry workers. The workers’ thermal perception was examined using the Heat Strain Score Index (HSSI) subjective assessment. Further, physiological parameters were recorded to evaluate the heat strain endured by workers. Work productivity losses under thermal work conditions were also estimated. Results: Higher occupational heat risk exposures were associated with furnace (Wet Bulb Globe Temperature (WBGT): 33.54°C (0.784), Tropical Summer Index (TSI): 38.82°C (3.273)) and metal pouring (WBGT: 32.93°C (0.663), TSI: 38.47°C (1.441)) sections, with indices exceeding permissible limits. From subjective assessment, 90% and 86.7% of workers in furnace and metal pouring section perceived higher thermal discomfort. A rise in workers’ physiological attributes was observed under sections involving high radiant heat exposure and intensive physical workload. Strong relations were observed among WBGT and HSSI indices (r = 0.831), indicating good agreement between quantitative and subjective assessments. With the exception of systolic and diastolic blood pressure, positive associations were seen among WBGT and monitored physiological variables (core body temperature (r = 0.705), skin temperature (r = 0.670), and heart rate (r = 0.353)). The productivity model estimated work performance losses associated with metal pouring (53%), furnace (43.24%), and fettling (37.61%) work sections under these foundry industries. Conclusion: Research findings indicated the need for sanative control measures based on ameliorating prevalent thermal work conditions found in this study. This study suggests that industrial/occupational health practitioners should analyse small-scale foundry industries for prevalent heat stress issues and develop new guidelines/standards to improve existing thermal work conditions in these industries.
Accommodation requests among older workers: The role of disability acceptance and other psychosocial factors
Authors: Dong Shengli , Zhou Kaiqi , Wu Jinlin
Published: December 2024

Background

With an aging workforce becoming increasingly prevalent in the United States, the intersection of older age and disability presents significant challenges for employment, particularly in the context of workplace accommodations.

Objective

This study aimed to elucidate the psychosocial factors influencing older workers’ requests and receipts of job accommodations, focusing on the pivotal role of disability acceptance.

Methods

Employing a quantitative approach, we included 217 older workers (50 years and older) across various employment sectors, analyzing their experiences with accommodation requests, workplace support, knowledge of the Americans with Disabilities Act (ADA), and levels of disability acceptance.

Results

Logistic regression models revealed that perceived workplace support significantly predicted the likelihood of requesting and receiving accommodations, whereas disability acceptance, despite its hypothesized importance, did not emerge as a significant predictor in our models. Results highlight the critical role of workplace support in facilitating accommodation processes for older workers and suggest that interventions to increase ADA awareness and foster supportive work environments may enhance accommodation outcomes.

Conclusion

This study contributes to a nuanced understanding of the dynamics surrounding accommodation requests among the aging workforce, emphasizing the need for inclusive workplace practices and policies.
Effect of traditional Chinese exercises on knee osteoarthritis: A network meta-analysis
Authors: Lv Meiling , Wang Jie , Chu Xin , Zeng Weisi , Wen Xiaoting
Published: December 2024

Background

Osteoarthritis is the third leading risk factor for disability in older adults.

Objective

To compare the efficacy of different traditional Chinese exercises on knee osteoarthritis by network meta-analysis, and to provide a reference basis for patients to choose the best method.

Methods

Seven databases, including Pubmed, Embase, The Cochrane Library, Web of Science, China National Knowledge Infrastructure, WanFang, and China Science and Technology Journal Database were searched for literature on traditional Chinese exercise to improve the symptoms of patients with knee osteoarthritis. The search period was from inception of the database until February 14, 2024. Literature screening and data extraction were carried out independently by 2 investigators, and the quality of the included studies was evaluated using the Cochrane Risk of Bias 2.0 assessment tool. R4.2.3 and Stata 15.0 were used for analysis.

Results

Forty-two studies involving 2843 patients were ultimately included, encompassing 4 kinds of traditional Chinese exercise. The surface under the cumulative ranking curve (SUCRA) showed that Baduanjin was the best traditional Chinese exercises for Western Ontario and McMaster University Osteoarthritis Index scores including pain score (SUCRA = 0.85), stiffness score (SUCRA = 0.87), physical function score (SUCRA = 0.88) and overall score (SUCRA = 0.83). For Visual Analog Scale pain score, the most effective traditional Chinese exercise was Tai Chi (SUCRA = 0.93).

Conclusion

The efficacy of Tai Chi, Baduanjin, Yijinjing, and Wuqinxi on knee osteoarthritis patients is superior to that of usual care. Baduanjin had the best effect in improving stiffness, physical function and overall score, and both Baduanjin and Tai Chi were the best options for improving pain.
Patients’ Experiences of Person-Centered Care in the Context of Allogenic Stem Cell Transplantation
Authors: O’Sullivan Anna , Lundh Hagelin Carina , Holmberg Katarina , Bergkvist Karin , Bala Sidona-Valentina , Wengström Yvonne , Malmborg Kisch Annika , Winterling Jeanette
Published: December 2024

Studies addressing patients’ experiences of person-centered care (PCC) in the context of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are scarce; hence, this study aimed to explore patients’ experiences of PCC, and its associations with individual characteristics and health-related quality of life, in the context of allogeneic stem cell transplantation. It is a cross-sectional survey study, in patients who had undergone an allo-HSCT at one center in Sweden. The PCC instrument for outpatient care in rheumatology (PCCoc/rheum) was used. Descriptive and analytical statistics were employed. The study had 126 participants, evenly distributed males and females, 18–79 years old (>60% were 50–69 years old), and most were (>70%) married or cohabiting. The sum score for all items on PCCoc/rheum ranged from 20 to 72 (higher score = higher degree of PCC), with a mean value of 62.67 (SD: 9.863). Most participants (87–99%) agreed with the level of person-centeredness for 22 of the 24 items. Of the participants, 83.3% agreed that they had undisturbed conversations, that their problems had been taken seriously (79.0%), that they had an opportunity to tell their story (77.8%), and collaboration with the nurse was good (77.6%). A sizeable proportion disagreed that the care environment was welcoming (11.9%), family members’ involvement (13.7%), and the possibility to influence the care (15.5%). The fulfillment of PCC was rated as high, but the results indicate that there is room for improvement regarding the possibility of influencing the care and family members’ involvement.
Intraarticular Nodular Fasciitis of the Elbow Confirmed by UPS6::MYH9 Gene Fusion
Authors: Adachi Shiro , Kukita Yoji , Nakamura Harumi , Tamura Hiromi , Doi Reiko , Kuriyama Kohji
Published: December 2024

Nodular fasciitis is a benign, usually self-limiting myofibroblastic proliferation with a predilection for the upper extremities, trunk, and head and neck, and almost all of which harbor the USP6::MYH9 fusion. Since nodular fasciitis is not widely recognized to arise within the joints, it may therefore cause diagnostic confusion in this uncommon setting. We report an unusual tumor of an 11-year-old patient who presented with a 6-month history of right elbow swelling and pain. Histology revealed that the tumor was composed solely of proliferating bland spindle cells with osteoclast-like giant cells and scattered foam cells. There was only a focal area of immature granulation-like myxoid change, which suggested nodular fasciitis. Molecular analysis using next-generation sequencing revealed gene rearrangement involving USP6 and MYH9, supporting the diagnosis of nodular fasciitis within the elbow joint. This is the first of intraarticular nodular fasciitis within the elbow joint in which USP6::MYH9 gene fusion was identified by molecular analysis.
Combined Ganglioneuroma-Schwannoma of the Retroperitoneum: An Exceedingly Rare Hybrid Nerve Sheath-Ganglioneural Tumor
Authors: Oon Ming Liang , Tan Hui Min , Tang Sarah S , Wijerathne Sujith , Pang Ning Qi , Ganpathi Iyer Shridhar , Ngiam Kee Yuan , Parameswaran Rajeev , Nga Min En
Published: December 2024

Combined ganglioneuroma-schwannoma is an exceedingly rare tumor that has only been described in isolated case reports. We document a 64-year-old man with an incidentally discovered combined ganglioneuroma-schwannoma of the retroperitoneum that was intimately associated with sympathetic ganglia. We highlight the morphological and immunohistochemical findings of this rare tumor, and show evidence of its origin from sympathetic ganglia.
Metatarsal Aneurysmal Bone Cysts Treated With En Bloc Resection and Reconstruction With Fibular Allograft
Authors: Hajialiloo Sami Sam , Toloue Ghamari Babak , Kargar Shooroki Khalil , Mohammadi Aniloo Fateme , Ammar Wael , Rikhtehgar Masih , Mohammadi Mohammad , Dehghani Firoozabadi Seyed Reza , Nahvizadeh Shima
Published: December 2024

Background:

Treatment of Primary metatarsal aneurysmal bone cyst (ABC) with curettage and bone grafting unfortunately has a high recurrence rate, particularly in short tubular bones. This study presents a 16-year experience treating ABCs in the bones of the foot at an orthopaedic oncology referral center. Treatment involved en bloc resection and reconstruction of the defect with fibular allograft in all cases. Retrospectively collected data were used to document the outcomes.

Methods:

This retrospective review includes patients with primary metatarsal ABC treated en bloc resection at a single center between 2004 and 2020. Information on the diagnosis, treatment, complications, and outcomes was collected from our database for all eligible patients. Radiologic healing was used as our primary outcome measure. The patient’s function was assessed using the Toronto Extremity Salvage Score (TESS) and Musculoskeletal Tumor Society (MSTS) score.

Results:

The study included 19 subjects (11 women, 8 men) with a mean age of 18 years (SD 11-35). The average resected length was 4.24 cm (3-6 cm). The mean follow-up time was 79.26 months (28-160 months). The mean TESS score and MSTS were 94.52 and 28.42, respectively. The average healing time was 10.2 weeks. No patient had local recurrence. Arthrodesis was performed in 3 patients because of joint involvement. Repeat surgery was performed for 2 patients, debridement for one because of infection and bone graft for another because of nonunion. One patient had experienced an allograft fracture.

Conclusion:

Based on the Enneking classification, our experience has shown that a reasonable surgical approach for primary active and invasive metatarsal ABC is en bloc resection and reconstruction with fibula allograft. This method has a low risk of recurrence and does not result in significant functional impairment.
Robust preview tracking control for LPV/LFR continuous-time systems
Authors: Li Li , Yu Xiao , Ye Hui
Published: December 2024

This study proposes a novel preview control method for linear parameter-varying (LPV) continuous-time systems (CTS) utilizing linear fractional representation (LFR). First, a formal system equivalent to the LFR of the LPV continuous system, which includes the preview compensation and tracking error, was developed to use the available reference signal values. In order to give innovative preview controller designs, the suggested conditions then depend on the utilization of decision matrices and slack variables related to the LFR technique. To provide minimal conservative synthesis criteria to the LPV/LFR continuous-time system, parameter-dependent Lyapunov functions and full-block multipliers were also taken into consideration. To create reliable state-feedback and output-feedback tracking controllers with preview actions, the design conditions were modeled as linear matrix inequalities (LMIs). Two scenarios were simulated to show how effective the suggested control strategy is.
Complicit in the Catastrophe: Practical Progress With Deleuze and Guattari
Authors: Robson Ian
Published: December 2024

Taking the starting point that working with the concepts of Deleuze and Guattari requires relentless experimentation, this article builds on recent scholarship and (anti) methodological experiments to advance the boundaries of that work in qualitative research. Through a new and experimental encounter with one of their qualitative studies, the author grapples with the experience of embracing Deleuze and Guattari’s key concepts and what they mean—in this case—for their research practices. Their events, insights, and breakthroughs are presented through an imagined art exhibition and catalog entries dealing with the process.
Rheological, microbiological, and in vitro digestive properties of Kefir produced with different Kefir grains and commercial starter cultures
Authors: Comak Gocer Emine Mine , Ergin Zeren Firuze , Ozen Küçükcetin İkbal , Kucukcetin Ahmet
Published: December 2024

This research investigates the production of kefir using Turkish and Kazakh kefir grains and commercial starter cultures, followed by storage at 4 °C for 30 days. The study monitors the rheological properties and microbiological characteristics of kefir on the 1st, 15th, and 30th days of storage, as well as during dynamic in vitro gastrointestinal digestion. Kefir samples were passed through a dynamic in vitro gastrointestinal model simulating the digestive processes of the mouth, stomach, and small intestine which was designed in laboratory conditions. Kefir from Turkish kefir grain exhibited the lowest average titratable acidity, apparent viscosity, and flow behavior index, while kefir from Kazakh kefir grain had the highest average pH. Over the storage period, pH and flow behavior index decreased, while titratable acidity, viscosity, and consistency coefficient increased. The kefir samples showed non-Newtonian pseudoplastic flow characteristics. The acetic acid bacteria and Leuconostoc counts of kefir samples produced with commercial starter cultures were higher than those produced with kefir grains, while yeast counts were higher in kefir samples produced with kefir grains. During storage and in vitro gastrointestinal digestion, the number of microorganisms in kefir samples decreased. Turkish kefir grain resulted in the lowest reduction (%) of microorganism counts during in vitro gastrointestinal digestion. These findings shed light on the rheological, microbiological, and in vitro digestive properties of kefir during storage, which may contribute to improving the quality and health benefits of kefir products. The present study revealed that the kefir produced with kefir grains had a lower decrease in the viability of microorganisms compared to the kefir produced with starter culture after passage through the gastrointestinal model, so kefir produced with kefir grains may be more preferred due to its possible health benefits.
Arteriovenous access creation for hemodialysis patients with superior vena cava occlusion
Authors: Qiuping Luo , Lizhu Jin , Zhiqiang Duan , Jia Hu , Tianlei Cui
Published: December 2024

Background:

The feasibility of creating arteriovenous (AV) access in hemodialysis patients with superior vena cava occlusion (SVCO) is debated due to impaired blood return to the right atrium. However, collateral venous networks may offer an alternative solution, allowing for the creation of peripheral AV access. This study evaluates the outcomes of AV access construction in hemodialysis patients with SVCO.

Methods:

A retrospective review of 18 patients with SVCO and patent azygous veins was conducted between August 2021 and June 2023. These patients underwent peripheral AV access creation, including fistulas and grafts. Collected data included baseline demographics, preoperative 3D CT reconstruction of thoracic vessels, central venography, vascular access types, surgical details, postoperative complications, and the timing and methods of interventions.

Results:

AV access was successfully created in all patients, including 15 AV fistulas and 3 AV grafts. The average brachial blood flow rate before cannulation was 848.67 ± 132.03 mL/min. The median follow-up period was 18.5 months (range: 10–32 months). During follow-up, six patients required interventions, such as flow reduction or percutaneous transluminal angioplasty, to optimize blood flow or resolve venous obstruction. Two cases were classified as failed access at 10 and 18 months post-creation. One patient transitioned to peritoneal dialysis due to AVG dysfunction, while the other underwent bypass surgery for chylothorax.

Conclusion:

AV access can be successfully created and maintained in patients with SVCO and a patent azygous vein. Although mild venous obstruction symptoms may develop during follow-up, timely intervention can preserve access patency. For patients with limited vascular resources and challenging catheterization, this approach represents a viable option for establishing effective access.
Development and validation of a tool for ambulatory monitoring of peripherally inserted central catheter-associated complications
Authors: Sofie Segers , Jodie Langbeen , Stijn Blot , Wim Terryn , Mieke Debrauwere , Dirk Vogelaers
Published: December 2024

Introduction:

Peripherally inserted central catheters (PICC) are the preferred vascular access for Outpatient Parenteral Antimicrobial Therapy (OPAT) due to user-friendliness and high safety level. Nevertheless, the lack of a validated tool hampers the yet ill-charted epidemiology and monitoring of PICC related complications in ambulatory care.

Methods:

A sequential exploratory mixed-method three phase research design was used to develop and validate a monitoring tool for PICC complications in OPAT. A literature review and co-design approach allowed its development, followed by Delphi panel content validation. In a third phase, the tool was piloted and implemented for further evaluation, including adherence.

Results:

Twelve and nine experts respectively participated in the first and second Delphi round (response rate: 92% resp. 69%). Scale-level Content Validity Index based on the Average Method was 0.99 and 0.90 in the first and the second Delphi round respectively. After the Delphi procedure, the tool consisted of the following relevant items: (1) functionality (injection and aspiration), (2) insertion site, (3) catheter fixation, (4) infection and (5) thrombosis. After positive pilot testing, the tool was implemented in 17 participants with outcomes measured in 15 participants. Two participants were readmitted and three experienced PICC complications. As for adherence, the monitoring tool was partially or fully completed 285 times (74,8%); external catheter length was rarely or never reported and systematic follow-up of the temperature scored poorly.

Conclusion:

A tool for ambulatory monitoring of PICC-associated complications with a solid content validity was obtained. Future research should consist of a multicentric larger size assessment and digitalization.
A meta-analytic review of cognitive behavior therapy and motivational interviewing for adolescent and young adult sleep concerns
Authors: Vrabec Alison , Milligan Megan A , Antshel Kevin M , Kidwell Katherine M
Published: December 2024

Cognitive behavioral therapy (CBT) is an evidenced-based treatment for sleep concerns but may be insufficient on its own to resolve adolescent sleep problems – combining this treatment with motivational interviewing may result in more robust improvements to sleep in adolescents and young adults (AYA). This study aimed to conduct the first meta-analysis of integrated CBT and motivational interviewing (MI) for AYA sleep concerns. Following PRISMA guidelines, PsycINFO, PubMed, and Google Scholar were searched through January 2024. Cohen’s d was computed for effect sizes. Eligible articles included AYA utilized an integration of CBT and MI, reported quantitative outcomes related to sleep, and were published in peer-reviewed journals and available in English. Four studies were eligible for the meta-analysis ( N = 435). Results showed a small-medium effect size for reduced daytime sleepiness ( d = 0.39, p = .001) and increased total sleep time ( d = 0.25, p = .008) following integrated CBT and MI. Risk of bias was assessed using CMA. The findings suggest integrated CBT and MI is beneficial for AYA daytime sleepiness and sleep duration, more effective than CBT alone and other control groups. These findings contribute to the understanding of effective interventions for AYA sleep concerns, offer practical insights for practitioners, and highlight the need for further investigation into the integration of CBT and MI.
Introduction to the special issue “Mobilising queer joy: Establishing queer joy studies”
Authors: Wright JJ , Burkholder Casey
Published: December 2024

Our introduction to the special issue “Mobilising Queer Joy” reflects an urgent need for queer joy studies amidst a sociopolitical climate that feels increasingly ruinous. We reject the ‘joy deficit’ in sociological research that fixates on homogenous, misery-filled visions of 2SLGBTQIA+ existence, and which is severed from the profound beauty of queer love, queer and trans joy, gender euphoria, and the strength and depth of 2SLGBTQIA+ community care and chosen families. In addition to introducing the six articles in the special issue from authors in Canada, the Philippines, Australia, and the US, we aim to establish queer joy studies by articulating the affective power of queer joy for collective resistance and social transformation. Queer joy is more than a kitschy slogan on a tote bag or splashed on the side of a big bank’s Pride float; it is a collective experience that allows us to feel more alive and connected to our personal capacities and power. The queer joy we are interested in is dangerous to empire and colonial powers. It does not deny the relationship with ambivalence, rage, and grief, and instead mobilises these affects to confront injustices in our existing social order. Some of the questions we ask include: How does queer joy act as world-making and dream mapping of new, more sustainable futures? How might we further theorize and mobilise queer joy as a disruption to settler colonial, carceral logics? How might the transformative power of queer joy be amplified to fragment and challenge the rise of fascism and populism that seeks to exterminate it?
Unmet need for and barriers to receiving health care and social welfare services in Finland
Authors: Ilmarinen Katja M. , Aalto Anna-Mari , Muuri Anu L.
Published: December 2024

Aim:

Need-based access to health care and social welfare services is an element of health promotion, and it endorses equity and the principles of universalism in society. To explore access to services, this study analyses unmet need for services, barriers that impede access and whether individual characteristics are associated with service access. The study period coincided with the COVID-19-pandemic and health and social services reform in Finland.

Method:

The prevalence of subjective unmet need was used as an indicator of service access. Inconvenient opening hours, a difficult journey to the service unit and high user fees were barriers to receiving services. A nationally representative FinSote survey 2018 and 2020 was used in the analyses. Data were examined with multivariate logistic regression models using SPSS.

Results:

A high prevalence of unmet need for health care and especially for social welfare services was observed. The prevalence of unmet need increased from 2018 to 2020, but in health care only, and access to social welfare services deteriorated. In particular, women, younger people, those who need income support and those with poor health or quality of life forgo care.

Conclusions:

A considerable share of the Finnish population do not receive essential services according to need and face barriers in accessing services. Individual characteristics are associated with perceived unmet need and access barriers despite the ethos of equal opportunities. COVID-19 measures are likely to have worsened the situation. Actions to improve access must urgently be implemented to achieve the policy goals of health promotion, equity in health and universalism.
Formulating and Prioritizing CSR Strategies: A Marketing Strategy-Informed Approach
Authors: Wetzel Hauke A. , Hammerschmidt Maik , Lenz Isabell
Published: December 2024

A major challenge for CSR managers is the lack of strategic guidance for their decisions. No prior research has offered a framework that clarifies when which CSR initiative is advised. To address this gap, the authors argue that capitalizing on insights from marketing strategy empowers CSR decisions that cater to the demands of stakeholders and in turn pay off for the firm. The first marketing strategy principle—strategy formulation—leads to the distinction of four unique CSR strategies that link different relational approaches to the needs of different stakeholder groups (market stakeholder promotion, institutional stakeholder promotion, market stakeholder protection, and institutional stakeholder protection). The second marketing strategy principle—strategy prioritization—informs how to effectively deploy CSR strategies by matching them with marketing’s relative strategic emphasis (on value appropriation vs. value creation). The novel framework is tested with panel data from 3,572 firms over 19 years. The study reveals that the alignment of CSR strategies with marketing’s relative strategic emphasis is key for CSR’s effect on firm performance. Institutional stakeholder promotion fits best when value appropriation is the dominant marketing emphasis while market stakeholder protection matches best with an emphasis on value creation. A major implication of the study is that bringing marketing strategists to the CSR table helps firms to identify those CSR initiatives that also yield a business case for the firm.