bluuebunny/crossref_metadata_2025 huggingface dataset:
Metropolization and regional development in Czechia during the transformation period
Authors: Hampl Martin , Marada Miroslav
Published: February 2020

Roughly 60% of the population of the state and almost 70% of its economy are concentrated in metropolitan areas. Fundamental social changes after 1989 encouraged an increase in their development dynamism, but also deepened the differences in it. Significant polarity of the growth dynamism between the Prague metropolitan area on the one hand, and four metropolitan areas with a dominance of heavy industry (metropolitan areas of Ostrava, Ústí nad Labem, Most and Karlovy Vary) on the other, were typical of the first transformation decade (1991–2001). In the second decennium (2001–2011), the regional differentiation of development was smaller, but the total dynamism of territorial concentration of both the population and economy kept growing. The Prague area may have retained the fastest development, but not on such an extreme level as in the first decade. The main development polarisation shifted to the level “metropolitan areas – other non-metropolitan areas”.
Local economic impact of big sport events: the case study of the World championship in ice hockey 2011 in Bratislava
Authors: Rehák Štefan , Štofko Michal
Published: February 2020

Hosting major sporting events has become an important instrument that brings new impulses for urban and regional development. There is a range of positive and negative impacts in the economic, social, political, and cultural domains, as well as urban regeneration and infrastructure development. This article focuses on an analysis of short-term local impacts of the World Championship in Ice Hockey 2011 in Bratislava, which was based on an extensive survey of visitor expenditures followed by input/output modelling of indirect local effect. Our survey showed that approximately 83,000 non-local visitors spent almost 11 million euros during the event. We estimated that the direct economic impact of the World Championship was 7.5 million euros, of which the largest part was spent on the sphere of hotels and restaurants. The total (direct and indirect) economic impact of visitor spending was 13.6 million euros. Moreover, another 104 million euros was an additional economic impact of related local investments in the sports infrastructure.
BENTUK ZIKIR DAN FUNGSINYA DALAM KEHIDUPAN SEORANG MUSLIM
Authors: Muniruddin Muniruddin
Published: February 2020

Abstrak
Allah SWT telah menciptakan manusia sebaik-baik makhluk ciptaanNya yang dilengkapi dengan panca indera, namun sejauh mana manusia itu mampu memahami fungsi indrawi potensial kekhalifahan dalam mengemban bentuk yang paling baik (ahsani taqwim) dalam menjalani hidup dan kehidupan sehari-hari yang harus seimbang antara pemikiran dan zikir secara mahdhoh terhadap Ilahi. Karena jika tidak ada pikir dan zikir atau salah satu tidak ada, maka hidup seseorang akan mengalami kegoncangan yang dahsyat serta
pada gilirannya akan terpleset jatuh yang sangat menyakitkan. Zikir merupakan kata kunci dalam sebutan lidah secara kontiniu dan i’tiqad yang tidak putus di dalam hati serta direalisasikan dalam bentuk praktek hidup dan kehidupan.

Kata Kunci: Hati, hidup, zikir
STRATEGIC DIRECTIONS OF ORGANIZATION GARLIC BUSINESS IN UKRAINE
Authors: ZUBAR Ivan
Published: February 2020

The article considers the current state of the garlic market in the world. It is determined that garlic is one of the most widely used crops in the world and has a wide range of uses, which makes it a promising object of business interests.

An overview of the dominant trends in the production of garlic, the capacity of the world market, price aspects and formed the top 5 countries-exorcists of this product. The trend of gradual growth of volumes of deliveries and currency earnings has been recorded.

The tendencies of export-import circulation of garlic are analyzed, features of production and realization of this product in Ukraine are determined. The key problems of domestic garlic are outlined.

A description of the varietal conglomeration of domestic garlic selection was carried out. On the basis of author's data, the calculation of the efficiency of using different planting material and landing schemes was made. Also calculated the expediency of storing garlic in vegetable stores and selling it in winter. On the basis of which are summarized the main vectors of the organization of profitable garlic business in the countryside.

According to the results of the conducted research, a number of problematic factors that restrain the effective development of this industry in Ukraine are proposed and the key paradigmatic directions of their solution are proposed.
MANAGEMENT OF THE EXPENSES OF AGRICULTURAL ENTERPRISE IN THE CONTEXT OF EXPOSURE TO THE OPERATIONAL ARM
Authors: MAKOGON Vitaliy , GOROH Alexander
Published: February 2020

It has been established that the stronger is the price fluctuations on the sunflower and other agricultural products, the more powerful is their influence on the formation of financial results of the industries with the high capital intensity of production and with a larger share of the fixed costs in the total production costs. In its turn the better infrastructure support for the sunflower seed market and the use of the forward operations allow to level the negative multiplicative effect of the operational leverage on the formation of the financial results of this industry. The latter determines the necessity to accelerate the development of the infrastructural segments of the agrarian market which are not suitable for the forward operations. The results of the study are used in developing the recommendations regarding the management of the agricultural enterprises expenses.
METHODS OF COST ACCOUNTING IN THE ACCOUNTING POLICIES OF AGRICULTURAL ENTERPRISES
Authors: BURKO Kateryna
Published: February 2020

Modern enterprise production management is a complex, time-consuming and multifaceted process. It sets new requirements for the organization of cost accounting and needs to expand control over the formation of production cost by industries, cost centers, technological redistribution, types of products (works, services). There is also a need to determine the impact of costs on the implementation of the latest technologies and improve product quality.

Important elements of accounting policies are cost accounting methods. The correct choice and use of cost accounting methods contribute to a quick assessment of the appropriateness of spending. At present, the legislation of Ukraine does not specify a specific method of applying certain methods of cost accounting. The imperfection of modern domestic methods of cost accounting creates certain difficulties in their choice to solve the tasks set before the enterprise.

The purpose of the article is to reveal the essence of cost accounting methods and to determine the most effective ones for consolidation in the accounting policy of agricultural enterprises.

In the article the question of estimation of the role of registration policies is exposed in the process of the enterprise management. The component elements of registration politics are certainly connected with the account of spending. Different approaches of the researchers are considered in relation to the essence of methods of accounting costs and their classification. It is set that classification of methods of accounting of productive costs is the object of scientific discussions and generally accepted classification of methods has not been developed yet. The author gives general characteristics of the features of agricultural enterprises activities that have considerable influence on the process of administrative decision-making and directly determine the construction of the accounts of costs. Certainly, methods of cost accounting are the important element of registration policy of agricultural enterprises.

Systematization of branch and organizational factors that influence the choice of the methods for cost accounting at agricultural enterprises is carried out. The use of the combined methods for accounting the costs is suggested, that is conditioned by the branch features of agricultural enterprises activity and formation of registration policy concerning cost accounting.
THE STATE OF INNOVATION ACTIVITY IN UKRAINE IN COMPARISON WITH EU COUNTRIES
Authors: STOLYARCHUK Nadiya
Published: February 2020

The sources and amount of financing of internal expenses for carrying out scientific researches and developments are determined. It has been established that mainly scientific research is financed from the state budget, sources of foreign sources rank second, and the third place is occupied by the funds of organizations of the entrepreneurial sector. It was proved that the enterprises and organizations working in the sphere of education and science showed the greatest activity in the sphere of protection of intellectual property objects among the national applicants. Analysis of the innovation activity of the National Academy of Agrarian Sciences of Ukraine was carried out and it was defined that the general tendency of received security documents for the objects of intellectual property for 2015-2017 is negative. It was established that according to the report of the World Economic Forum on Global Competitiveness, "The Global Competitiveness Report 2016-2017," Ukraine ranked 85th among the 138 surveyed countries. It was determined that Ukraine's highest rating is based on the indicator "Higher, secondary and vocational education" – the 33d.

The share of innovative products in the balance sheets of the countries with developed innovation environment, such as the EU, USA, Japan, is 23,14 and 13,8% respectively was considered. However, the share of innovation in the balance of Ukrainian enterprises is only 2%. It has been established that the new era of the innovative economy necessitates the institutional correction of accounting by recognizing new intellectual assets, adopting sectoral accounting, assessment and internal audit, and creating specialized structures that will strengthen the role of accounting through the formation of an information field and reduce the uncertainty of economic environment.
INSTITUTIONAL FOUNDATIONS OF STATE SUPPORT FOR AGRICULTURAL SECTOR DEVELOPMENT
Authors: KALASHNIKOVA Tetiana , KALASHNIKOV Andrii
Published: February 2020

The article analyzes the transformational changes of the institutional foundations of state support of Ukraine’s agricultural sector. The analysis of the institutional foundations of the state support influence on indicators of the agricultural sector development in the conditions of changes in the state fiscal policy has been carried out. Based on the results of correlation-regression analysis, it has been determined that an increase in the state support amount creates preconditions for the sustainable development of the agricultural sector, while the increase of its administrative costs significantly slows down the parameters of its development. The analysis of the amount and structure of financing state support programs for the agricultural sector during the last three years has been carried out, what allowed characterizing the institutional foundations of their regulatory influence on the agricultural sector development. The main reasons for the low efficiency of institutionalization of certain programs of state support of the agricultural sector have been determined.
ACCOUNTING SUPPORT OF THE MARKETING STRATEGY MANAGEMENT OF AN ENTERPRISE
Authors: PRAVDIUK Nataliia
Published: February 2020

The article substantiates and develops organizational and economic mechanism for the formation of accounting support for the marketing strategy management at the enterprise.

The methodological basis of the research is the historical and logical method used to study the essence of the marketing strategy and its constituent elements in the overall hierarchy of enterprise development strategies. The dialectical method and comparative analysis are used to study the information support of the marketing strategy management at the enterprise and current practice of representing the costs of marketing activities of the enterprise in the accounting. The methods of scientific abstraction, induction and deduction, analysis and synthesis are used to improve the plan of accounts and financial reporting in terms of cost accounting for the marketing activities.

The structure of the information support of marketing strategy management, which includes information resources generated by the external and internal environment of the enterprise, is investigated based on the substantiation of the importance of developing and implementing the marketing strategy of the enterprise under conditions of modern business environment. It is established that the basis of information support of the marketing strategy management at the enterprise is the accounting system of the enterprise. To form a qualitative accounting and information support of the marketing strategy management at the enterprise, the classification of expenses for the marketing activity and the procedure of their documentary registration are generalized, and guidelines on the display of accounting information in the accounts and financial statements are provided, which will enable to assess the efficiency and cost effectiveness of implementation of the marketing strategy by the business entity, as well as to estimate the level of achievement of the target parameters of the activity.

Elements of scientific novelty consists in the organizational and methodical mechanism of formation of the accounting and information support of the marketing strategy management at the enterprise in accordance with the components of the marketing complex (commodity, sales, price and communication policy), which enables to generate information flows in necessary analytical terms according to the needs and specifics of management, is suggested.

Proposals on the cost accounting of marketing activities of the enterprise are suggested, which meet the requirements of the current legislation, which regulates accounting and financial reporting in Ukraine, and they may be used in the accounting practice of domestic enterprises.
Unpublished art works of Volodymyr Sichynskyi. Systematization issues and prospects for research
Authors: Patyk Roksolana
Published: February 2020

Volodymyr Sichynskyi's art studies have been researched, which remain under-researched and little-known in the scientific community, some of which have not yet been published. First of all, we know about the works «Fine Arts (Industrial, Historical and Folk Art)», «Dictionary of Ukrainian Artists», «Methodological Scheme of Art Studies», «History of Ukrainian Art». The work of the scientist is characterized by a European approach to the study, research and art of generalizing scientific material. His scientific and creative achievements are presented to the world community by the greatness of Ukrainian culture and art.
ROLE OF CELLS OF INNATE IMMUNITY IN THE DEVELOPMENT OF MALIGNANT TUMORS OF THE BRAIN
Authors: Lysіаniy Mykola , Belskaya Lyudmila , Gnіdkova Irina , Palamaryova Nastya
Published: February 2020

This review presents data on changes in the activity of cells of innate and acquired immunity, namely leukocytes, neutrophils, platelets and lymphocytes in various malignant human tumors, including brain tumors. It was shown that against the background of immunosuppression of specific immunity, especially antitumor reactions, which are caused by factors such as prostaglandin E2, TGF-β, indolamine-2,3-dioxigenase (IDO) and interleukin (IL) -10, which leads to a decrease the sensitivity of T cells to proinflammatory signals and the ineffectiveness of the presentation of tumor antigens to immune cells, activation and polarization of innate immunity cells, namely neutrophils, macrophages and platelets, occurs.

Macrophages are important immune cells of the microenvironment in a tumor site that change their phenotype from M1 cells with antitumor activity to M2, which enhance tumor growth. The release of metalloprotheasis from platelet α -granules destroys the components of the extracellular matrix, increases the ability of cancer cells to pass through the endothelial barrier, penetrate the parenchyma and create metastatic tissue damage. Previously, neutrophils were mainly considered as cells of the body’s first line of defense, mainly with antimicrobial functions, but now they are regarded as cells with tumor-stimulating, “protumorogenic” activity, since in many types of cancer an increased level of neutron is determined with a reduced content of lymphocytes in the peripheral blood and this is associated with a poor prognosis of the disease. The review analyzes the hypothesis that there are three subpopulations of neutrophils in cancer: normal high density neutrophils, immature low density neutrophils (G-MDSC) and large mature low density neutrophils. These types of cells have different functions, for example, neutrophils with high density are antitumor, and with low density - cells that can stimulate tumor growth. ]. Neutrophils realize their activity through molecules such as neutrophilic elastase (NE), cathepsin, arginase 1 (ARG1), matrix metalloproteinase-9 (MMP-9). Multidirectional changes in the parts of the immune system depend on the histogenesis and degree of malignancy of the tumors and indicate differentiated use immunotropic drugs in cancer patients, some should suppress the activity of innate immunity cells, others stimulate the acquired immune response.
SEROPREVALENCE OF ANTI-MEASLES IGG IN THE POPULATION OF KHARKIV REGION IN 2018-2019
Authors: Yudin Igor , Kuchma Irina , Voliansky Andriy
Published: February 2020

Aim. The aim of this study was to evaluate herd immunity against measles in different age groups of the Kharkiv region of Ukraine’s population.

Materials and methods. Seroprevalence of specific IgG antibodies was studied among different age groups of the Kharkiv region population from February 2018 to July 2019 by ELISA method.

Results. A number of 6564 sera samples were processed. The overall seropositivity level was 91.3%; negative results were 5.3% and 3.3% equivocal. The highest seropositivity for IgG (> 98%) was in people aged 50 years and older. The lowest seropositivity rates were observed in the cohorts of 20-29 years (87.2%), 30-39 years (86.9%), and 40-49 years (91.1%).

Conclusions. Measles-susceptible populations were identified for which new prevention strategies should be applied in the form of personalized vaccination campaigns to increase herd immunity.
THE STATE OF THE MUCOSAL IMMUNITY OF THE ROGENITAL TRACT IN PATIENTS WITH VARIOUS VARIANTS OF CLINICAL COURSE OF ACUTE UNCOMPLICATED PYELONEPHRITIS
Authors: Rudenko Adel , Pasechnikov Serhii , Mitchenko Mykola , Kornilina Olena
Published: February 2020

The purpose of the work was to investigate the state of mucosal immunity of the urinary and genital tract in patients with acute uncomplicated pyelonephritis (AUP), depending on the severity of the disease.

Methods. 124 women with AUP and with concomitant chronic inflammatory diseases of the pelvic organs (CIDPO) and 23 clinically healthy women were examined. To assess the clinical picture of AUP was used a division into 3 variants of the clinical course (VCC): mild (n = 105), moderate severity (n = 90) and severe (n = 51). Humoral indicators of mucosal immunity were determined in 64 urine samples and 121 vaginal washings by enzymelinked immunosorbent assay. The levels of immunoglobulins (Ig) A, M, G, secretory IgA (sIgA), lactoferrin (LF) myeloperoxidase (MPO) and lysozyme, C3-component of complement (C3), secretory component, tumor necrosis factor-α (TNF-α) were determined. The concentration of β -defensin-2 was determined in vaginal washings, and the levels of interleukins 10 and 15 – in urine.

Results. A significant increase of the concentration of C3, LF, lysozyme, MPO, sIgA, and TNF-α relative to their reference values was found in the urine of patients with different variants of clinical course of AUP. The smallest median values for LF, lysozyme and MPO were recorded in patients with severe VCC AUP. An increase of TNF-α level was more characteristic for patients with moderate severity and severe VCT. The highest increase of IgA, IgM, IgG levels was found in patients with mild VCT. Significantly elevated levels of MPO, IgA, IgG and TNF-α were detected in vaginal washings in women of all groups relative to reference indicators. The highest (p<0.05) increase in the level of non-specific immunity factors (lysozyme and MPO) was observed in vaginal washings in patients with severe VCT, and specific (IgA, IgM and IgG) – in patients with mild VCT.

Conclusions. In patients with various clinical course of AUP, a significant increase of the humoral factors of nonspecific and specific immunity and cytokines in urine was established relative to reference indicators; to a lesser extent for non-specific indicators of immunity and to a greater extent for TNF-α in patients with severe VCT. Concomitant CIDPO contributed to the greatest increase in washings of MPO and lysozyme levels in patients with severe VCT, and the level of immunoglobulins of all classes – in patients with mild.
Phytotoxic Effect and Bioaccumulation of Chromium in White Mustard (Sinapis alba L.) Seedlings
Authors: Popoviciu Dan Razvan , Pirjol Ticuta Negreanu , Miclaus Lucian Stefan
Published: February 2020

The chromium bioaccumulation potential in Sinapis alba L. was studied in experimental hydroponic conditions. Mustard seedlings were grown in nutrient solution containing 50, 100, 250 and 500 ppm Cr. After 10 days, seedlings were analyzed for shoot length, biomass, leaf pigment (chlorophylls and carotenoids) and tissular Cr concentration. The Biological Accumulation Coefficients (BAC) were also determined. Cr content in S. alba dry mass reached 415-2,064 ppm, depending on ambient Cr concentration. BAC ranged between 8.30 to 4.13, with a peak at 100 ppm and lowest values at higher concentrations. Shoot length, biomass and pigment concentration values showed an average decrease at high Cr concentrations (mostly, at 500 ppm), without a definite statistical significance. Results indicate that S. alba is tolerant to high Cr levels and has hyperaccumulative abilities.
Water Quality and Self-purification Capacity Assessment of Snagov Lake
Authors: Stefan Daniela Simina , Neacsu Nicoleta , Pincovschi Irina , Stefan Mircea
Published: February 2020

The aim of this paper is to identify the spatial and temporal distribution of chemical and physical parameters that characterize the water quality, the trophic state and the self-purification capacity assessment of Snagov Lake. The Snagov Lake is a natural lake located at 25-30 km North from Romania�s capital, Bucharest. The study was conducted during a five years period, from April 2010 until October 2014. The measurements used (temperature, pH, dissolved oxygen, transparency, chlorophyll-a, total phosphorus, TN/TP ratio) are presented in the form of spatial and temporal evolutions. For self-purification identification the aerobic mineralization degree, biological depuration factor and TN/TP ratio were used. The trophic stage of Snagov Lake in the range and in all the points of sampling is eutrophic�hipereutrophic for all the parameters used for assessment, excepting several short periods of time (fall of 2010, spring and fall of 2011) when the lake was in mesotrophic state.
Improving the Corrosion Behaviour of 6061 Aluminum Alloy by Controlled Anodic Formed Oxide Layer
Authors: Dumitrascu Valentin Marian , Benea Lidia
Published: February 2020

This research work investigates the influence of anodic oxide film obtained in sulphuric electrolyte on the corrosion behavior of 6061 aluminum alloy in natural sea water. Corrosion behavior of untreated and anodized 6061 aluminum alloy was studied using electrochemical methods such as: open circuit potential and electrochemical impedance spectroscopy. All the tests were performed in an aerate sea water with pH=7.63 at room temperature (25oC). The electrochemical results are in good agreement with optical microscopy images. The polarization resistance of aluminum oxide film increases as compared with the untreated aluminum alloy this showing an improving of corrosion resistance after anodic oxidation. These results demonstrate the advantages of the as-fabricated anodic oxide layer as a barrier thin film to marine corrosion.
Numerical Approach for Catalytic Conversion of CO2 to Methane over Nickel Base Catalysts
Authors: Marinoiu Adriana , Carcadea Elena , Cobzaru Claudia , Cernatescu Corina
Published: February 2020

The study evaluates the performances of the Ni/Al2O3-SiO2 base catalysts prepared by impregnation technique by catalytic hydrogenation of CO2 to methane on temperature range of 350-550oC under atmospheric pressure. We take into account the important parameters namely reaction temperature, H2/CO2 molar ratio. Targeting a very high conversion rate of CO2 and almost total methane selectivity at up to 400oC catalysts like Ni/Al2O3-SiO2 were proposed. The performances of these catalysts were analysed by table Curve software. The mathematical model corresponding to the characteristic equation provides a good arrangement of the experimental points on the responding surface, simplicity of the characteristic equation and a good determination coefficient that is near unity.
Mesoionic 4-(2-Dialkylamino-1,3-dithiol-2-ylium-4-yl)phenolates
Authors: Chirita Paul , Asaftei Iuliean Vasile , Sandu Ion , Sarbu Laura Gabriela , Lupu Vasile Valeriu
Published: February 2020

New mesoionic 4-(2-dialkylamino-1,3-dithiol-2-ylium-4-yl)phenolates have been obtained from the corresponding 1,3-dithiolium salts under weak basic conditions. The 1,3-dithiolium salts have been synthesized by the cyclocondensation of 1-(4-hydroxyphenyl)-1-oxaethan-2-yl dithiocarbamates. The latter compounds have been obtained from the reaction of the 2-bromo-1-(4-hydroxyphenyl)ethan-1-one with various salts of dithiocarbamic acids. UV-Vis investigations proved the intramolecular charge transfer for the mesoionic 1,3-dithiolium phenolates.
Invertase Production by Fungi, Characterization of Enzyme Activity and Kinetic Parameters
Authors: Matei Gabi Mirela , Matei Sorin , Pele Maria , Dumitrescu Flavia , Matei Adrian
Published: February 2020

The present paper presents the results of research carried out on 14 fungal isolates of various origins aiming to select new efficient sources for invertase production for further biotechnological application. Aspergillus flavus presented the highest protein content and Aspergillus niger, the most intense invertase activity. The relationship between enzyme concentration and enzymatic activity at 0.25 mM mL-1sucrose as substrate assayed for successive decimal dilutions of Aspergillus niger enzyme ranging from 0.1 to 1mlLrevealed a linear correspondence between 0.1 and 0.5mL. The kinetic parameters Michaelis-Menten constant (Km) and maximal velocity (Vmax) for invertase activity of Aspergillus niger, Penicillium aurantiogriseum, Aspergillus wentii and Rhizopus stolonifer were calculated. The determination coefficients R2 calculated from Lineweaver-Burk plots presented values very close or equal to 1.
Ozone Concentration Prediction using Artificial Neural Networks
Authors: Gavrila Camelia
Published: February 2020

The aim of this paper is to determine a mathematical model which establishes the relationship between ozone levels together with other meteorological data and air quality. The model is valid for any season and for any area and is based on real-time data measured in Bucharest and its surroundings. This study is based on research using artificial neural networks to model nonlinear relationships between the concentration of immission of ozone and the meteorological factors: relative humidity (RH), global solar radiation (SR), air temperature (TEMP). The ozone concentration depends on following primary pollutants: nitrogen oxides (NO, NO2), carbon monoxide (CO). To achieve this, the Levenberg-Marquardt algorithm was implemented in Scilab, a numerical computation software. Performed sensitivity tests proved the robustness of the model and its applicability in predicting the ozone on short-term.
PRF to Enhance the Esthetic Outcome of Surgical Treatment of Cutaneous Chronic Fistula
Authors: Di Lauro Alessandro Espedito , Calniceanu Horia , Scotto Fabio , Stratul Stefan , Rusu Darian , Boariu Marius , Rusu Laura Cristina , Siciliano Vicenzo Iorio
Published: February 2020

Cutaneous odontogenic fistulas or sinus tracts are uncommon manifestations of chronic dental infections that typically begin at the apex and discharge the suppurative material through the skin. They usually respond to conventional endodontic treatment or to removal of the causative tooth, leaving often very unesthetic retractile scars. For esthetic reasons, surgical treatment is sometimes necessary to remove the sinus tract. Platelet-Rich Fibrin (PRF) is an autologous source of growth factors obtained from the centrifugated blood of the patient, supporting collagen synthesis, tissue repair and accelerating the wound healing. This is the first to demonstrate the surgical technique using membrane-shaped PRF after resective surgery of a cutaneous sinus tract, simultaneous with the removal of the causative tooth, in comparison with a case treated only with removal of the dental starting point of the infection. The benefic role of this technique in the esthetic post-surgical healing is suggested.
The Impact of Ozone Therapy on Antioxidant Status and Quality of Life in Palliative Care - Exploratory Study
Authors: Totolici Irinel Petru , Pascu Alina Mihaela , Poroch Vladimir , Mosoiu Daniela
Published: February 2020

There is a constant concern about finding new or alternative therapeutical approaches for symptom control and quality of life that are essential in palliative care. Ozone therapy has been studied for over a century, since the development of the first medical ozone-generator able to ensure a correct titration of the ozone-oxygen mixture. When used in precise therapeutic doses O3 prove many consistent and safe therapeutic benefits, with minimal and preventable side actions. Our prospective exploratory study aimed to analyze the effects of ozone therapy administration on palliative care patients, by dynamically monitoring the antioxidant status (superoxide-dismutase and glutathione-peroxidase serum levels), pain perception, and quality of life. The results confirm ozone therapy as a promising alternative adjuvant therapy for increasing the quality of life in palliative care services.
Copper, Manganese and Zinc Bioaccumulation in Some Common Poaceae Species Along Romanian Black Sea Coast
Authors: Pirjol Bogdan Stefan Negreanu , Pirjol Ticuta Negreanu , Popoviciu Dan Razvan
Published: February 2020

Copper, manganese and zinc bioaccumulation potential was screened for three common Poaceae species, Hordeum murinum ssp. murinum L., Leymus racemosus ssp. sabulosus (M. Bieb.) Tzvelev and Lollium perenne L., abundantly growing along the Romanian Black Sea Coastal area, Constanta County. The concentration of the selected heavy metals was analyzed though atomic absorption spectrometry in samples of aboveground plant organs and soils. To assess the potential for phytoaccumulation, the Biological Accumulation Coefficients (BAC) were calculated. Considering the minimal thresholds widely accepted in literature for Cu, Mn and Zn hyperaccumulators, none of the selected species can fit in this category. The highest average copper concentration was found in Hordeum murinum ssp. murinum L. (5.45 mg/kg). For manganese, the highest value was found in Lollium perenne L. (104.08 mg/kg), while for zinc, the maximum was reached in Leymus racemosus ssp. sabulosus (M. Bieb.) Tzvelev, tissue (62.95 mg/kg). BAC values showed that all species are manganese excluders, with a remarkable maximum value of 0.55 in Lollium perenne. L. All species had average BAC above 1 for Cu and Zn, with a maximum in Leymus racemosus ssp. sabulosus (M. Bieb.) Tzvelev (4.85 and 2.98, respectively). However, there was a significant variation among individuals, usually, a high metal content in plant tissue being associated with low metal concentration in soil. The exception was Lollium perenne L., with BAC constantly above 1 (average BAC of 2.27 for Cu and 1.69 for Zn). These results emphasize a significant potential for phytostabilization of copper- and zinc-rich soils and open the way for heavy metals phytoextraction capacity studies of the Poaceae species along Romanian littoral.
Study Regarding the Bahaviour of an Insulating Vegetable Oil Exposed to Accelerated Thermal Aging
Authors: Budrugeac Petru , Lingvay Iosif , Pica Alexandra , Sbarcea Beatrice Gabriela
Published: February 2020

The simultaneous thermal analysis method (thermogravimetry/derivative thermogravimetry + differential thermal analysis (TG/DTG+DTA) and determination of iodine index have been used for characterization of an experimental vegetable insulating oil exposed to thermal cyclic and isothermal accelerated aging in pure state and in contact with red copper. The results obtained by thermal analyses show that three main successive processes of thermo-oxidation occur at progressive heating of initial (un-aged) and thermal aged oil samples. The accelerated thermal aging determines the change of composition and thermal properties of oil, which involves the formation of sites with an oxidative reactivity greater than those from initial (un-aged) oil. It has been put in evidence the catalytic role of red copper in the process of oil oxidation. The change of composition of oil as result of thermal aging also results from the decrease of iodine index. The general mechanism of auto-oxidation of vegetable oils gives a qualitative explanation of obtained results.
Modeling an Energy Storage System Based on a Hybrid Renewable Energy System in Stand-alone Applications
Authors: Ciocan Alexandru , Balan Ovidiu Mihai , Buga Mihaela Ramona , Prisecaru Tudor , Tazerout Mohand
Published: February 2020

The current paper presents an energy storage system that stores the excessive energy, provided by a hybrid system of renewable energy sources, in the form of compressed air and thermal heat. Using energy storage systems together with renewable energy sources represents a major challenge that could ensure the transition to a viable economic future and a decarbonized economy. Thermodynamic calculations are conducted to investigate the performance of such systems by using Matlab simulation tools. The results indicate the values of primary and global efficiencies for various operating scenarios for the energy storage systems which use compressed air as medium storage, and shows that these could be very effective systems, proving the possibility to supply to the final user three types of energy: electricity, heat and cold function of his needs.
Relatii de estimare a conversiei etanolului si randamentului in hidrogen utilizand reteaua neuronala pentru reformarea cu abur a etanolului pe catalizator de Co/Al2O3
Authors: Doicin Bogdan , Ezeanu Dorin Stanica , Cursaru Diana
Published: February 2020

An artificial neural network has been developed for estimation of ethanol conversion and hydrogen yield function of reaction conditions in ethanol steam reforming process based on Co/Al2O3. Ethanol (8% and 10% vol) was considered as raw material for hydrogen production by steam reforming. For this investigation, we have created an artificial neural network to describe the complex relationship between ethanol steam reforming and the Co/Al2O3 catalyst used in the process. To test the estimation accuracy of the created neural network, a set of input data, whose outputs are already known was used. For these input data, the output data are calculated and then compared with the known outputs.
Technological Solution for the Treatment of Wastewater Resulting from Autochthonous Aquacultures in Order to Protect the Marine Water Quality
Authors: Tociu Carmen , Zaharia Tania , Diacu Elena , Maria Cristina , Marinescu Florica , Ilie Mihaela
Published: February 2020

This paper depicts the research conducted at a micro-pilot scale on autochthonous cultures in order to develop adequate technological solutions for the treatment of wastewater resulting from shrimp cultures (Palaemonidae) that would ensure the protection of the Black Sea ecosystem and constitute an applicable tool for the development of aquaculture in Romania. The proposed objectives were attained by adopting an integrated system of marine cultures shrimps-mussels-macrophyte algae, followed by a conventional chemical treatment step using aluminium sulphate recovered from metallurgical slags. This system together with wastewater treatment ensures an optimum development of species and a minimum load of pollutants in the aquatic environment.
Adherence and Biofilm Formation in Candida albicans Strains Isolated from Different Infection Sites in Hospitalized Patients
Authors: Sadik Omar , Ditu Lia Mara , Gheorghe Irina , Gradisteanu Pircalabioru Gratiela , Bleotu Coralia , Banu Otilia , Merezeanu Nicoleta , Lupu Andrei Cristian , Lazar Veronica , Chifiriuc Mariana Carmen
Published: February 2020

Adherence of Candida albicans to the cellular and inert substratum contributes to its commensal status, but also plays an essential role in the development of fungal infections, particularly in hospitalized and immunodepressed patients. This study evaluated the adherence capacity and biofilm formation of 109 C. albicans strains isolated from upper respiratory tract secretions, wound secretions, urine culture, blood culture and stool culture taken from patients hospitalized for cardiovascular surgery. The strains were originally identified as C. albicans, based on their morphological characteristics and then confirmed by the Vitek II automatic system. All tested strains adhered to the cellular substratum, the isolates from stool culture, urine and thrush secretion exhibiting the most intensive adhesion capacity, the predominant adherence pattern being the aggregative one. Patient age and gender did not exhibit a significant influence on the adhesion process. The strains with the highest biofilm production capacity were the ones isolated from respiratory tract secretions and urine cultures. Statistically significant correlations could be established among a high number of yeast cells adhered to HeLa cells and i) the aggregative adherence pattern and ii) the moderate to high capacity to form biofilms on the inert substratum. These results could suggest the implication of common fungal structures in the colonization of inert and cellular substrata, while the elucidation of the molecular mechanisms involved in these processes could bring an important benefit to the appropriate management of fungal infections, depending on the isolation source.
Drug Delivery Systems for Lymphatic Uptake
Authors: Marti Daniela , Coricovac Dorina , Pinzaru Iulia , Isaia Anca , Susan Razvan , Ionescu Daniela , Suciu Oana , Susan Monica , Lazureanu Voichita
Published: February 2020

The lymphatic system is considered to be the second circulatory system within the body, responsible for the maintenance of fluid homeostasis and immune protection. Among the aforementioned roles, it was proved that lymphatics are involved in dissemination of cancer and infections. This review offers a short description of the physiological features of lymphatic network, the lymphatic transport and the main drug delivery systems for lymphatic uptake.
Behavior of Doped Hydroxyapatites During the Heat Treatment
Authors: Goga Firuta , Forizs Edit , Borodi George , Tomoaia Gheorghe , Avram Alexandra , Balint Reka , Mocanu Aurora , Horovitz Ossi , Tomoaia Cotisel Maria
Published: February 2020

The goal of this investigation is related to the development of nanostructured biomaterials based on hydroxyapatite (HAP) and multi-doped hydroxyapatites (HAPs), with essential physiological elements, like Mg, Zn, Sr, and Si, for bone repair and regeneration. Nano hydroxyapatites pastes and powders were obtained by wet chemical method using innovative nanotechnology and advanced processing of biomaterials at various temperatures to control the crystallite size and crystallinity degree. The prepared HAPs were analysed by various physical and chemical methods, like SEM, SEM-EDX, AFM, XRD, TG and DSC analysis. The results showed that these biomaterials both in pastes and in powders contained a unique phase, characterized by the HAP structure, which was substantially preserved even at 1000 oC, indicating a high thermal stability of these biomaterials. To enhance their usage, we have prepared HAP and multi-doped HAPs in the form of pastes with controlled humidity (moisture) and powders with controlled crystallinity, which were lyophilized or lyophilized calcined at 300 oC for 1 h. Preliminary biological tests showed that the adhesion and proliferation of human osteoblasts depended on the heat treatment of HAPs used for building the scaffolds. The findings suggest that these biomaterials based on HAPs may have a wide range of medical applications as bone substitute and coatings on metallic implants.
Correlation Between the Salivary Level of Alpha-amylase and the Risk for Dental Caries in Young Permanent Teeth
Authors: Sitaru Alexandru , Tohati Adrian , Pop Anca Maria , Bica Cristina
Published: February 2020

Human saliva is a complex mixture of fluids considered to have a real potential in maintaining the dental health, carrying out important functions in the local modulation of inflammatory reactions and immune response. The biologic properties of salivary alpha-amylase are a subject of intense debate in the scientific literature, regarding its use as a biomarker for local and systemic diseases, including caries lesions. The purpose of our study was to measure the correlation between the salivary level of alpha-amylase and the incidence of caries in a group of children with young permanent teeth. A total of 128 participants were included in four study groups according to presence or absence of dental caries, based on specific inclusion/exclusion criteria and a scoring system between 0-5, depending on gender and the number of caries lesions. From each patient, 10 mL of saliva was collected and examined with a spectrophotometer in order to determine the level of salivary alpha-amylase. The collected data were statistically analyzed with the GraphPad Prism 7.03 and Mann-Whitneytest, a value of p [0.05 being considered statistically significant. Our results showed that caries active children had higher levels of salivary enzyme compared to caries free groups (p=0.001). Therefore, we concluded that salivary alpha-amylase can be considered a biomarker for the prognosis of dental caries development, offering new perspectives for preventive dentistry.
Polylactic Acid 3D Printed Drill Guide for Dental Implants Using CBCT
Authors: David Ovidiu Tiberiu , Szuhanek Camelia , Tuce Robert Angelo , David Andra Patricia , Leretter Marius
Published: February 2020

The aim of the present study is to describe a method for setting up a polylactic acid (PLA) 3D printed surgical guide for the minimally invasive insertion of dental implants using the CBCT (cone beam computed tomography) acquisition without occlusal contact and CAD � CAM (computer-aided design/computer assisted manufacture) software for its design, production and testing.
Variation of Phytochemicals Content in Pulp and Skin of Seven Romanian Apple Cultivars
Authors: Oprica Lacramioara , Atofanei Doina , Poroch Vladimir
Published: February 2020

The amounts of anthocyanins, flavonoids, total polyphenol and ascorbic acid in seven apple cultivars from Romania were investigated. The amounts of polyphenol and flavonoids in pulp and skin of apple cultivars ranged between 17.18�7.52 mg GAE/g DW and 20.10�11.06 mg CE/g DW as well as 3.64�1.18 mg GAE/g DW and 10.31�5.57 mg CE/g DW, respectively. The highest and smallest values of ascorbic acid both in the skin and the pulp were observed in the cultivars Mutsu and Starkrimson. The anthocyanin content is positively correlated with the colour intensity of the apple epicarp, being about three-fold higher in Prima than Golden Delicious cultivar. The better antioxidant activity provided by the content of polyphenol, ascorbic acid and flavonoids was in apple fruits of Mutsu cultivar and for this reason it should be regarded as a valuable source of antioxidants.
The Fatty Acids Composition and Antioxidant Activity of Walnut Cold Press Oil
Authors: Copolovici Dana , Bungau Simona , Boscencu Rica , Tit Delia Mirela , Copolovici Lucian
Published: February 2020

The fatty acids composition and antioxidant activity have been determinate for cold press walnut oil. It has been found that the total saturated fatty acids have been 8.8 % while poly unsaturated fatty acids have been 72.84 %. The ratio between omega-6 and omega-3 has been determined as 5.06 which could help in human healthy diet. On the same side, the antioxidant activity of the oil is very high at a level of 3.65 mmol L-1 and a ratio between lipophilic and hydrophilic fractions of 9.45.
Three-dimensional Marginal Evaluation of Two Pressed Materials Using Micro-CT Technology
Authors: Baciu Sorana , Berece Cristian , Florea Adrian , Burde Alexandru Victor , Munteanu Anda , Cigu Toni Andor , Hosszu Tiberiu , Szuhanek Camelia , Manole Marius , Sinescu Cosmin
Published: February 2020

The main goal of the present study is to compare the marginal fit of two different kind of pressed materials: a partially crystalline thermoplastic resin reinforced with ceramic particles (BioHPP) and lithium disilicate (EMax), through the use of the microCT technique. After extraction of four caries-free mandibular first molars, first class inlay cavities were prepared. For each tooth two inlays were manufactured- one by using BioHPP thermoplastic resin (n=4) and one by using Emax Press lithium disilicate (n=4). The marginal gap was analyzed circumferentially at the occlusal margin using a Bruker micro CT, by measuring the distance at the occlusal limit of the cavities, between the restoration and the tooth in several points for every surface of each tooth before cementing. Data were analyzed statistically using the Mann-Whitney U test and the Pearson�s correlation coefficient (a=0.05). A significant statistical difference was found between the marginal gap size obtained for BioHPP and Emax inlays (p[0.001). For the Emax inlays the marginal gap had an average of 72mm, while for BioHPP the average was 94 �m. Both types of used materials offer a good marginal adaptation. By summing up the gathered data we can conclude that the pressed ceramics shows a better marginal fit than the pressed resin, probably because of the different processing methods: sintering versus polymerizing with different shrinkage values.
Study on the Influence of the Treatment in Magnetic Field on the Nitrided Layer in Plasma
Authors: Papadatu Carmen Penelopi , Sandu Andrei Victor , Bordei Marian , Sandu Ioan Gabriel
Published: February 2020

These researches have been made in order to improve the mechanical properties of a Chromium�Molybdenum alloyed steel non-conventionally treated in a magnetic field. Through the thermo-magnetic treatments, applied before thermo-chemical treatment, the mechanical properties of this material have been improved, especially in the case of a great content of chromium. The hardness values of the superficial layers which have been obtained after a complex system of thermo-magnetic treatments followed by a thermo-chemical treatment, the superficial layers content and the behaviour of the steel at the wear through dry friction tests were used as criterion. The paper is a review of the researches from the last few years.