bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling timing and tempo of adrenarche in a prospective cohort study
Authors: Dashti S. Ghazaleh , Mundy Lisa , Goddings Anne-Lise , Canterford Louise , Viner Russell M. , Carlin John B. , Patton George , Moreno-Betancur Margarita
Published: December 2022

To better understand how health risk processes are linked to adrenarche, measures of adrenarcheal timing and tempo are needed. Our objective was to describe and classify adrenal trajectories, in terms of timing and tempo, in a population of children transitioning to adolescence with repeated measurements of salivary dehydroepiandrosterone (DHEA), DHEA-sulphate, and testosterone. We analysed data from the Childhood to Adolescence Transition Study (CATS), a longitudinal study of 1239 participants, recruited at 8–9 years old and followed up annually. Saliva samples were assayed for adrenal hormones. Linear mixed-effect models with subject-specific random intercepts and slopes were used to model longitudinal hormone trajectories by sex and derive measures of adrenarcheal timing and tempo. The median values for all hormones were higher at each consecutive study wave for both sexes, and higher for females than males. For all hormones, between-individual variation in hormone levels at age 9 (timing) was moderately large and similar for females and males. Between-individual variation in hormone progression over time (tempo) was of moderate magnitude compared with the population average age-slope, which itself was small compared with overall hormone level at each age. This suggests that between-individual variation in tempo was less important for modelling hormone trajectories. Between-individual variation in timing was more important for determining relative adrenal hormonal level in childhood than tempo. This finding suggests that adrenal hormonal levels at age 8–9 years can be used to predict relative levels in early adolescence (up to 13 years).
Analyzing online public commentary responding to the announcement of deemed consent organ donation legislation in the Canadian province of Nova Scotia
Authors: Marcon Alessandro R. , Wagner Darren N. , Rachul Christen , Weiss Matthew J.
Published: December 2022

Background

The Canadian province of Nova Scotia recently became the first jurisdiction in North America to pass deemed consent organ donation legislation. The announcement of this legislation generated substantial online discussion, which we analyzed to provide insights on public perception.

Methods

We performed directed content analysis on 2663 user-generated comments appearing on two widely-shared Canadian Broadcasting Company (CBC) articles published online in April 2019. We determined levels of support and opposition in comments and described the specific rhetoric used for doing so. We also performed one-way ANOVA and Pearson chi-square tests to determine how the comments were being received and engaged by other users.

Results

A range of commentary was present in both support and opposition to the changes in legislation. There were more negative than positive comments, and negative commentary generated more replies. Positive comments were received more positively by other users while negative comments were received more negatively. The total sum of negative comments was greatly influenced by a small number of very active participants. Negative commentary focused more on broad concepts and principles related to government, power, and individual rights rather than specific issues in the Nova Scotian context. Substantial issues of trust in the government and healthcare system were evident.

Conclusions

There were strong positive and negative sentiments expressed in the comments, but the total sum of negativity in the comments was significantly influenced by a small number of commentators. Analysis on the presumed consent concerns can be helpful to inform public outreach efforts.
Development of a 3D simulator for training the mouse in utero electroporation
Authors: Nuber Maximilian , Gonzalez-Uarquin Fernando , Neufurth Meik , Brockmann Marc A. , Baumgart Jan , Baumgart Nadine
Published: December 2022

In utero electroporation (IUE) requires high-level training in microinjection through the mouse uterine wall into the lateral ventricle of the mouse brain. Training for IUE is currently being performed in live mice as no artificial models allow simulations yet. This study aimed to develop an anatomically realistic 3D printed simulator to train IUE in mice. To this end, we created embryo models containing lateral ventricles. We coupled them to uterus models in six steps: (1) computed tomography imaging, (2) 3D model segmentation, (3) 3D model refinement, (4) mold creation to cast the actual model, (5) 3D mold printing, and (6) mold casting the molds with a mix of soft silicones to ensure the hardness and consistency of the uterus and embryo. The results showed that the simulator assembly successfully recreated the IUE. The compression test did not differ in the mechanical properties of the real embryo or in the required load for uterus displacement. Furthermore, more than 90% of the users approved the simulator as an introduction to IUE and considered that the simulator could help reduce the number of animals for training. Despite current limitations, our 3D simulator enabled a realistic experience for initial approximations to the IUE and is a real alternative for implementing the 3Rs. We are currently working on refining the model.
Prognostic impact of catheter ablation in patients with asymptomatic atrial fibrillation
Authors: Kawaji Tetsuma , Shizuta Satoshi , Tanaka Munekazu , Nishiwaki Shushi , Aizawa Takanori , Yamagami Shintaro , Komasa Akihiro , Yoshizawa Takashi , Kato Masashi , Yokomatsu Takafumi , Miki Shinji , Ono Koh , Kimura Takeshi
Published: December 2022

Background

Catheter ablation for asymptomatic atrial fibrillation (AF) remains controversial. The aim of the present study was to explore the prognostic impact of catheter ablation in asymptomatic AF patients.

Methods

We performed a post-hoc analysis of 537 risk-matched pairs of AF patients receiving first-time catheter ablation or conservative management. The primary outcome measure was a composite of cardiovascular death, heart failure (HF) hospitalization, ischemic stroke, or major bleeding. The study patients were divided into asymptomatic and symptomatic patients, and were further divided according to the presence or absence of previous AF-related complications (ischemic stroke or HF hospitalization).

Results

Most baseline characteristics were well balanced between the catheter ablation versus conservative management groups. The median follow-up period was 5.3 years. Catheter ablation as compared to conservative management was associated with significantly lower incidence of the primary outcome measure in the asymptomatic AF patients (14.7% versus 25.4% at 8-year, log-rank P = 0.008). However, the advantage of catheter ablation was significant only in the high-risk subset of patients with the previous AF-related complications (19.2% versus 55.6% at 8-year, log-rank P = 0.006), but not in those without (13.9% and 17.3%, P = 0.08). On the other hand, among the symptomatic AF patients, catheter ablation was associated with significantly lower incidence of the primary outcome measure regardless of the previous AF-related complications.

Conclusions

In the post-hoc analysis of the matched AF cohort, catheter ablation as compared with conservative management was associated with better long-term clinical outcomes among asymptomatic AF patients only when the previous AF-related complications were present.
Cost-effectiveness of PARP inhibitors in malignancies: A systematic review
Authors: Ding Haiying , He Chaoneng , Tong Yinghui , Fang Qilu , Mi Xiufang , Chen Lingya , Xin Wenxiu , Fang Luo
Published: December 2022

Objectives

Poly (ADP-ribose) polymerase inhibitor (PARPi) have become a mainstay for the treatment of BRCA-mutant malignancies. PARPis are likely to be more effective but also bring an increase in costs. Thus, we aimed at evaluating the cost effectiveness of PARPis in the treatment of malignancies.

Methods

Studies of cost effectiveness of PARPis were searched from PubMed, Web of Science, and Cochrane Library. Key information was extracted from the identified studies and reviewed. Quality of the included studies was evaluated using Quality of Health Economic Studies (QHES) instrument. Modeling techniques, measurement of parameters and uncertainty analysis were analyzed across studies. Interventions and cost-effectiveness results were reported stratified by patient population.

Results

Among the 25 studies identified, we included 17 on ovarian cancer, 2 on breast cancer, 3 on pancreatic cancer, and 3 on prostate cancer that involved olaparib, niraparib, rucaparib, and talazoparib. All studies had a QHES score of above 75. In the maintenance therapy of ovarian cancer, additional administration of olaparib was cost-effective for newly diagnosed patients after first-line platinum-based chemotherapy but was not cost-effective for platinum-sensitive recurrent patients in majority studies. However, the economic value of other PARPis in ovarian cancer as well as all PARPis in other tumors remained controversial. Cost-effectiveness of PARPi was primarily impacted by the costs of PARPi, survival time, health utility and discount rate. Moreover, genetic testing improved the cost-effectiveness of PARPi treatment.

Conclusions

PARPi is potentially cost-effective for patients with ovarian, pancreatic, or prostate cancer. Genetic testing can improve the cost-effectiveness of PARPi.
Genome wide CRISPR screen for Pasteurella multocida toxin (PMT) binding proteins reveals LDL Receptor Related Protein 1 (LRP1) as crucial cellular receptor
Authors: Schoellkopf Julian , Mueller Thomas , Hippchen Lena , Mueller Teresa , Reuten Raphael , Backofen Rolf , Orth Joachim , Schmidt Gudula
Published: December 2022

PMT is a protein toxin produced by Pasteurella multocida serotypes A and D. As causative agent of atrophic rhinitis in swine, it leads to rapid degradation of the nasal turbinate bone. The toxin acts as a deamidase to modify a crucial glutamine in heterotrimeric G proteins, which results in constitutive activation of the G proteins and permanent stimulation of numerous downstream signaling pathways. Using a lentiviral based genome wide CRISPR knockout screen in combination with a lethal toxin chimera, consisting of full length inactive PMT and the catalytic domain of diphtheria toxin, we identified the LRP1 gene encoding the Low-Density Lipoprotein Receptor-related protein 1 as a critical host factor for PMT function. Loss of LRP1 reduced PMT binding and abolished the cellular response and deamidation of heterotrimeric G proteins, confirming LRP1 to be crucial for PMT uptake. Expression of LRP1 or cluster 4 of LRP1 restored intoxication of the knockout cells. In summary our data demonstrate LRP1 as crucial host entry factor for PMT intoxication by acting as its primary cell surface receptor.
Síndrome de boca ardiente, abordaje otorrinolaringológico. Revisión bibliográfica sistemática
Authors: San Millán-González María , Benito-Orejas José Ignacio , Duque-Holguera Victoria , Álvarez-Álvarez María , Losada-Campa Juan , Saboya-Romero Diana Milena
Published: December 2022

Introducción y objetivo: El síndrome de boca ardiente (SBA) es una afección crónica, que cursa con quemazón o dolor de la mucosa bucal, afectando predominantemente a mujeres de edad media. Puede aparecer como cuadro primario o bien de forma secundaria. La fisiopatología de esta entidad es bastante desconocida. Existe un amplio abanico terapéutico, pero por lo general precisa de un abordaje multidisciplinar. Nuestra intención es realizar una puesta al día de la enfermedad para poder hacerla frente en la consulta de otorrinolaringología. Método: Revisión bibliográfica de la literatura. Fecha de publicación limitada de 2012 a 2022. Resultados: El SBA presenta una etiopatogenia de carácter multifactorial. Para su diagnóstico es necesario realizar una exhaustiva anamnesis y exploración. Se diferencian 3 tipos distintos de SBA, siendo el tipo II el más frecuente y el más refractario a la terapia. El adecuado tratamiento se fundamenta en un correcto diagnóstico y debe ser multidisciplinar. Discusión: Es importante resaltar que es una entidad benigna. Los tratamientos son variados y no hay ninguno que destaque sobre el resto, lo que dificulta el manejo de estos pacientes. Aunque la bibliografía sobre este síndrome es abundante, no se han producido en los últimos años, importantes innovaciones en cuanto a la etiología y tratamiento. Conclusiones: La anamnesis y los estudios de laboratorio son fundamentales para descartar casusas secundarias de la enfermedad. La terapia es diversa y debe incluir derivación a salud mental como parte del manejo multidisciplinar.
Islamic Peace Centered Theology
Authors: Machasin Machasin
Published: December 2022

Although has been so far portrayed as religion of violence, the very essence of Islam is peace. The use of violence in such concepts of jihād (waging holy war) and shahīd (martyr) is actually only allowed in the last resort. Besides, it does not belong to the main precepts of Islam as presented in the arkān al-īmān (the pillars of belief) and the arkān al-islām (the pillars of obligations). This paper argues that peace constitutes the essential part of Islamic theology and that the mission of every human being in Islamic teaching is to be God’s vicegerent on the earth. This mission for a true believer may not be achieved unless he or she works with others in building peace, not by force. Violence can only be used to protect the freedom of as many as members of the community to live peacefully.
Religion and Tradition in Modern Turkey as Reflected in Orhan Pamuk’s Snow Novel: An Analysis of Social Deixis
Authors: Karimah Annisa Nur , Wahyudi Jarot
Published: December 2022

The current study is dedicated to analyse the types of social deixis in Orhan Pamuk’s Snow Novel.Snow is a novel translated from the original Turkish-language novel entitled Kar. The reseacher is interested in the novel because it is telling about the clash of traditions, religion and modernization happening in Turkey In analysing the object of the study, the researcher  applied deixis theory introduced by C.J. Fillmore which concerned with social types of deixis. This study uses a qualitative descriptive method, which describes the phenomena that occur in the novel through the language spoken by the participants based on the context. The researcher undertook three steps in collecting the data, (1)reading the whole chapters of the Snow novel thoroughly to find the data that spread out within the novel and also to fully understand the context of the story, (2)making a list of the deictic expressions that spread out throughout the novel, (3)the researcher collected the data into the table and classified the data based on the social deixis type. As a result, the researcher found 40 forms of deictic expression within five types of social deixis. The data that have been collected from the source of data will be analyzed in several stages as follows, (1)analyzing the deictic expressions in Snow  novel, (2)classifying the data based on each kind of social deixis, (3)explaining the meaning of each kind of social deixis, (4)concluding. Out of five, only one type of social deixis used frquently by the author, i.e., ‘polite’. This is due to most of the participants do not have close relationship with each other.
Tree Detection and Localization Approach for UAV-based Forest Inspection
Authors: Battseren Batbayar , Mohamed Salim Harras , Diego Alejandro Orjuela Aguirre , Saleh Shadi , Hardt Wolfram
Published: December 2022

This paper addressed an UAV-based solution for forest inspection from the aspect of data processing. Insect infected trees can be identified from aerial imagery. The forest inspection data processing divided into two main phases, which are tree detection and tree localization. For the tree detection task, the Deep Learning-based approach has been used. In this study, a conventional and active learning method have been used for the training. In order to map the detected trees from the video frame to geographical locations, a custom geo-localization algorithm has been developed. The proposed system loads the inspection video as an input and calculates and outputs the detected trees’ GPS coordinates. In the calculation Digital Elevation Model and camera parameters are used in addition to drone geo-data to calculate the tree positions.
Cranial Dislocation of Infrarenal Aortic Endoprostheses During Transcatheter Aortic Valve Replacement
Authors: Singla Atul , DeMaioribus Christopher , Bishu Kalkidan , Stam Marc D. , Schultz Jason
Published: December 2022

This report describes the complexity of transcatheter aortic valve replacement in which rare complications sometimes occur, even at experienced centers. This is a case of cranial migration of an infrarenal aortic aneurysm endograft while advancing the balloon-expandable prosthesis through the infrarenal aorta, which was subsequently successfully treated by deploying a thoracic endoprosthesis after deployment of the aortic valve bioprosthesis.
BELİRLİ SÜRELİ İŞ SÖZLEŞMESİNİN SONA ERMESİNİN İŞÇİ MENFAATLERİ AÇISINDAN DEĞERLENDİRİLMESİ
Authors: GÜRÜN KARATEPE Seçil
Published: December 2022

İş sözleşmesinin tarafları olan işçi ve işverenin istedikleri şekilde, sözleşme serbestisi prensibi çerçevesinde, sözleşme yapma özgürlüğüne sahip olmaları, Anayasa ve Kanunlarla güvence altına alınmıştır. Taraflar sözleşmenin türü ve içeriğini kendi iradeleriyle belirleyebilmektedirler. 4857 sayılı İş Kanunu’nun 9. maddesinde bu hak düzenlenmiş olup, kanundaki hükümlere aykırılık içermemesi şartıyla, taraflar ihtiyaçlarına ve isteklerine göre iş sözleşmelerini düzenleyebilmektedirler. İşçi menfaatleri bakımından önem arz eden; iş güvencesi hükümleri ile kıdem ve ihbar tazminatı alacakları, belirsiz süreli iş sözleşmesiyle çalışan işçilere kıyaslandığında, daha zayıf korumaları içeren belirli süreli iş sözleşmesiyle çalışan işçilerin, 4857 sayılı İş Kanunu ve 6098 sayılı Borçlar Kanunu çerçevesinde haklarını bilmeleri son derece önem arz etmektedir. Aksi takdirde çalışma hayatında işverenler tarafından haksızlıklar ve hakkın kötüye kullanılması durumlarıyla karşı karşıya kalabilmektedirler. Çalışmada belirli süreli iş sözleşmesinin ne olduğu, sözleşme yapabilmenin sınırları, sözleşmenin sonuçlarının işçilik menfaatleri açısından değerlendirilmesi hususlarında bilgiler yer almaktadır.
La belleza ante el reto de educar para la sostenibilidad
Authors: Puig Baguer Jordi , Casas Jericó María , Villarroya Ballarín Ana
Published: December 2022

El daño ambiental y la injusticia social son dos rasgos característicos del mundo contemporáneo. Ambos evidencian una falta de respeto hacia los valores naturales y humanos que la realidad, per se, posee. El descubrimiento de estos valores puede constituir una oportunidad para promover cambios de conducta que contribuyan a lograr una cultura más sostenible y justa. Tras examinar algunas posibles causas culturales de la insostenibilidad socio-ambiental, los autores plantean que la belleza que encierra la realidad puede desvelar a cada individuo valores naturales y humanos que antes no se percibían como tales. Este descubrimiento del valor interpela a la conducta personal e invita a la adopción libre de un compromiso de respeto hacia el mismo.
Sustainable Energy Management at KMUTT Thailand
Authors: Kanthamanon Prasert
Published: December 2022

King Mongkut’s University of Technology Thonburi (KMUTT) committed to be Sustainable University for SDGs 2030 since 2017 and committed to sustainability leadership in all of our activities from operations, teaching, to conducting research. Our commitments are to be a sustainable university providing a role model on Energy, Environment, Safety Management Systems and provide sustainability platform to promote sustainability leadership. Sustainable energy management system has been provided by top management policy since 2010 which focus on energy usage reduction, energy efficient appliances usage, renewable energy usage and carbon footprint reduction. To achieve the sustainable energy goal which comply to SDG 7: Affordable and Clean Energy and SDG13: Climate Action, KMUTT focus on student leadership which provide awareness raising, perception, and leading to implementation for all in KMUTT by using SEP for SDG concept. Moreover, KMUTT initiate sustainable strategy which provide the learning environment to make all campus as living lab, promote people participation and monitoring to make continual improvement with positive reinforcement. The sustainable energy goal achieved along with the expansion activities to community surround according to the student engagement. Keyword: energy management, sustainable energy, SEP for SDG, SDG 7, SDG 13
Implementation of Sustainable Transportation at Mahidol University, Salaya Campus, Thailand
Authors: Charmondusit Kitikorn , Wattanawinitchai Waratip , Mahisavariya Banchong
Published: December 2022

Mahidol University is one of the leading sustainable universities in Thailand, which recognizes the importance of combining actions to achieve the 17 Sustainable Development Goals of the United Nations (17 Sustainable Development Goals: 17 SDGs) and the concept of Sufficiency Economy Philosophy. The eco-university and sustainability policy was launched and implemented in 2021 in order to reach the 17 SDGs. Transportation is one of the important issues of campus development. In order to reduce the greenhouse gas emission from private fossil based fuel transportation, the public transportation both inside and outside the campus area is provided including electric tram, shuttle bus and public bicycle. An Electric cart with solar energy was initiated and used on campus. Walking and cycling as primary means for commuting on campus have been promoted by reduction of vehicle traffic. Cycling lanes are improved and bicycle racks are provided around the campus. Around more than 10,000 bicycles including more than 500 public bicycles were used on campus. The parking areas were constructed and adjusted into green open spaces. Many outdoor spaces are created to support various kinds of activities and gatherings enhancing liveliness and variety to campus lifeKeyword: Mahidol University, Mobility, Transportation, Green area, Sustainability campus
Powstawanie niedoborów kadrowych w szkolnictwie. Przegląd stanu badań oraz rekomendacje dla lokalnej polityki w zakresie usług edukacyjnych
Authors: Piróg Danuta
Published: December 2022

Niedobory kadrowe w szkolnictwie są w literaturze światowej ważnym przedmiotem badań nad usługami edukacyjnymi i rozwojem regionalnym. Problem ten, choć staje się ważki także w Polsce, dotąd nie był naukowo zgłębiany. Dlatego celemartykułu jest scharakteryzowanie procesów skutkujących niedoborami nauczycieli oraz działań sprzyjających obniżeniu ryzyka utraty płynności kadr w systemie edukacji jako ważnego zadania dla polityki regionalnej. W wyniku studiów literatury ustalono, że do niedoborów dochodzi przede wszystkim na skutek tzw. „wyciekania” z zawodu młodych nauczycieli, senioralizacji profesji oraz upowszechniania się alternatywnych modeli karier. Za działania skutecznie zapobiegające temu problemowi uznaje się m.in. „retencjonowanie kadr” i systemowe wspieranie integracji oraz socjalizacji młodych nauczycieli ze środowiskiem szkolnym.
Overconfidence and Public Intoxication Arrest: Evidence from a University Town Police Log
Authors: Hoffman Elizabeth , Kim Younjun
Published: December 2022

We show that overconfident individuals are likely to be arrested for public intoxication by using arrest records from a university town police log. This relationship is robust to various control variables such as risk aversion, time discounting, present bias, self-control, selfishness, loss aversion, and socializing with peers arrested for public intoxication. However, this relationship is no longer significant using only self-reported arrest data. We hypothesize that overconfident individuals are likely to underreport their arrests. This result has important implications for the use of self-reported data on public intoxication arrests rather than actual arrest records.
Attribution analysis of different driving forces on vegetation and streamflow variation in the Jialing River Basin, China
Authors: Li Qingsong , Gao Huishan , Chai Shan , He Zongyu , Ji Guangxing
Published: December 2022

As an important tributary of the Yangtze River basin, the Jialing River Basin (JRB) has a variable topography and fragile ecological environment. Under the influence of climate warming and human activities, the runoff and vegetation cover of the area are undergoing significant changes. For evaluating the impact of different factors on vegetation and streamflow variation in the JRB, the univariate linear regression method was employed to analyze the variation trend of streamflow and vegetation, and a heuristic segmentation algorithm was applied for identifying the mutation year of streamflow and NDVI time-series data in the JRB. Then, the influence degree of different factors on streamflow variation in the JRB was calculated by the Budyko equation and elastic coefficient method. Finally, the contribution rates of different factors to vegetation variation in the JRB were calculated by the multiple linear regression method. The results indicated that the mutation year of streamflow and NDVI time series data were 1985 and 2006, respectively. The contribution rates of climate factors and human activities to streamflow change in the JRB were 42.7 and 57.3%, respectively. The contribution rates to vegetation change were 28.89 and 71.11%, respectively. In general, human activities are the main driving force leading to runoff and vegetation changes in the JRB. This study can provide a theoretical basis for the ecological environment protection and water resources management of the JRB.
Book Review on Second Language Teaching and Learning through Virtual Exchange
Authors: Li Siying
Published: December 2022

This review briefly introduces an edited volume of recent empirical research on virtual exchange (VE) and second language education. It starts with a general introduction of VE and its potential to fulfil low-boundary interactions in pedagogical instructions, especially during the pandemic. Then it introduces the VE practices in the book from three dimensions: VE and language, VE and culture, as well as VE and teacher development. At last, it affirms the value of VE in improving the efficiency of foreign language education and teacher preparation, and provides suggestions for future studies.
Electrically controllable diffractive optical elements fabricated by direct laser writing on a carbon nanotube network film
Authors: Min Taeyol , Yim Jong Hyuk , Park Sungmin , Ha Seongju , Lee Soonil , Yeom Dong-Il
Published: December 2022

A randomly connected single-walled carbon nanotube (CNT) network film is suggested as an optically homogenous thin film to implement a tunable diffractive optical element with a subwavelength thickness. A Fresnel zone plate (FZP) as a thin-film lens is successfully realized by mask-free direct laser writing onto the CNT network film with a thickness of 450 nm. The fabricated FZP exhibits an intense three-dimensional focus having lateral and axial focal sizes of 0.95λ and 7.10λ, respectively, at the wavelength of 1550 nm. Furthermore, we show that the intensities at focal points of the first and second diffraction orders can be significantly modulated by 72% and 40% through ion-gel gating between +1.8 V and −1.8 V. These results may offer the potential for electro-optic tunability in multifocal diffraction flat optics and the like.
Nietzsches ästhetischer Umgang mit dem Politischen. Ein Versuch zu JGB VIII
Authors: Muniz Garcia André Luis
Published: December 2022

Nietzsche’s Aesthetic Approach to the Political. An Essay on BGE VIII. This article aims to present the aesthetic basis of Nietzsche’s dealings with politics in BGE VIII. In order to fulfill this task, the present text is divided into two parts: in the first part, I discuss how politics appears in BGE VIII as linked to a dispute over the concepts of “Völker” and “Vaterländer.” Understanding the meaning of these concepts requires an analysis of what I call the Nationenfrage. This question characterizes a theoretical effort in Europe to establish an authentic sense of personal and social identity. The contextualization of this theme is decisive for the second part of this article, in which I present Nietzsche’s strategies for carrying forth the debate concerning political phenomena, figures and events, based on purely aesthetic coordinates. The guiding theme will be the political phenomenon of democracy, which Nietzsche approaches both in BGE VIII and GS V. However, my goal is to make clear that Nietzsche’s interest in politics is conditioned by his interest in showing the aesthetic procedure of his philosophizing.
From relative proadverb to declarative complementizer: the evolution of the Hungarianhogyʻthatʼ
Authors: É. Kiss Katalin
Published: December 2022

The declarative complementizer has been claimed to have grammaticalized from a relative pronoun in various Indo-European languages. The source construction is assumed to have been the correlative sentence.The initial phase of the hypothesized process, however, has remained unclear; in the explicative clause to which e.g. the Germanicthat-type complementizers can be traced back(Mary knows that, that Peter is lying), thatis already a complementizer base-generated in C rather than a relative pronoun in Spec,CP. This paper analyzes a similar developmental path, that ofhogy‘that’, the Hungarian general complementizer cognate with the relative proadverbhogy‘how’, the early stages of which can be reconstructed more completely. It traceshogyback to a canonical correlative construction, and documents the subsequent stages of its evolution from a relative operator binding a variable in a correlative sentence, via a linker introducing an adjunct clause, to a complementizer subordinating a clausal argument to a matrix predicate.
Residual Stress Evaluation Using Finite Element Modeling in Turning of Ti-6Al-4V and Its Optimization Using RSM
Authors: Kant Vashisht , Kartheek Gamidi , Vamsi Krishna Pasam , Sukjamsri Chamaiporn
Published: December 2022

Residual stresses play a crucial role in the functional life of the component. Stresses develop because of mechanical and thermal loads during machining. Usually, compressive residual stresses are desirable for an improved fatigue life of the component. This study focuses on the effects of machining parameters on residual stresses while machining Ti-6Al-4V. A finite element model was developed and validated with experimental results. Different levels of cutting speed, feed rate, and depth of cut are used for evaluating residual stress, cutting force, and cutting temperature. Statistical modeling and optimization are carried out using response surface methodology. From the results it is observed that a machining speed of 45 m/min, a feed of 0.1 mm/rev, and a depth of cut of 1.84 mm help attain better responses. The feed and speed directly influence the residual stresses developed in machining. However, feed was found to be a more dominating parameter than speed.
A Comparative Analysis of Classification Algorithms for Cyberbullying Crime Detection: An Experimental Study of Twitter Social Media in Indonesia
Authors: Muzakir Ari , Syaputra Hadi , Panjaitan Febriyanti
Published: December 2022

Purpose: This research aims to identify content that contains cyberbullying on Twitter. We also conducted a comparative study of several classification algorithms, namely NB, DT, LR, and SVM. The dataset we use comes from Twitter data which is then manually labeled and validated by language experts. This study used 1065 data with a label distribution, namely 638 data with a non-bullying label and 427 with a bullying label.Methods: The weighting process for each word uses the bag of word (BOW) method, which uses three weighting features. The three-word vector weighting features used include unigram, bigram, and trigram. The experiment was conducted with two scenarios, namely testing to find the best accuracy value with the three features. The following scenario looks at the overall comparison of the algorithm's performance against all the features used.Result: The experimental results show that for the measurement of accuracy weighting based on features and algorithms, the SVM classification algorithm outperformed other algorithms with a percentage of 76%. Then for the weighting based on the average recall, the DT classification algorithm outperformed the other algorithms by an average of 76%. Another test for measuring overall performance (F-measure) based on accuracy and precision, the SVM classification algorithm, managed to outperform other algorithms with an F-measure of 82%.Value: Based on several experiments conducted, the SVM classification algorithm can detect words containing cyberbullying on social media.
Removal of copper ions from wastewater by adsorption onto a green adsorbent from winemaking wastes
Authors: Alcaraz Lorena , García-Díaz Irene , Alguacil Francisco J. , López Felix A.
Published: December 2022

Copper ion adsorption was studied using an activated carbon from winemaking wastes. The pH, temperature, activated carbon amount, and initial copper concentration were varied based on a full factorial 2k experimental design. Kinetic and thermodynamic studies were also performed. The adsorption kinetics followed a pseudo-second-order model. The adsorption data fit best to the Langmuir isotherm, compared with the Freundlich and Temkin models. The analysis of variance demonstrated that the pH and the activated carbon dosage had the greatest influences on the copper adsorption. The obtained activation energy suggested that the copper adsorption was physisorption. The best fit to a linear correlation was the moving boundary equation, which controls the kinetics of the adsorption of copper ions onto the activated carbon. X-ray photoelectron spectroscopy revealed the existence of different copper species (Cu2+, and Cu+ and/or Cu0) on the surface of the carbonaceous adsorbent after the adsorption, which could suggest a simultaneous reduction process.
The impact of the COVID-19 Pandemic on Language Teaching in Higher Education, CercleS survey
Authors: Schaffner Sabina , Stefanutti Isabella
Published: December 2022

In March 2020, the COVID-19 pandemic forced a move online of language teaching in Higher Education (HE). The CercleS survey on the impact of the COVID-19 Pandemic on language teaching in HE aimed to study teachers’ reflections on teaching during the pandemic and on the future of foreign language instruction. Data was collected between March and May 2021, and the answers reflect the voices of 725 teachers from CercleS member institutions of both national associations and associate members. The survey was written using a mixed method approach, based on a pragmatic epistemology. The findings indicate that the teachers moved flexibly into the online mode of teaching despite limitations in technological resources and the absence of training. Learning outcomes were met, and language skills were effectively taught, except for speaking skills. Generally, the respondents see the benefits of a blended/hybrid mode of instruction. Implications for teaching practices and stakeholders are as follows: develop guidelines and training for sustainable online and hybrid teaching; negotiate conditions needed to carry out efficient and sustainable language teaching with university management; and develop international collaboration between LCs in HE.
DETERMINATION OF THE FORCE IMPACT OF AN ION THRUSTER PLUME ON AN ORBITAL OBJECT VIA DEEP LEARNING
Authors:   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine, REDKA M. O. , KHOROSHYLOV S. V. ,   Institute of Technical Mechanics of the National Academy of Sciences of Ukraine and the State Space Agency of Ukraine
Published: December 2022

The subject of research is the process of creating a neural network model (NNM) for determining the force impact of an ion thruster (IT) plume on an orbital object during non-contact space debris removal. The work aims to develop NNMs and study the influence of various factors on the accuracy of determining the force transmitted by the ion plume of the thruster to a space debris object (SDO). The tasks to resolve are to choose the structures of the NNMs, form a data set and use this data to train and validate the NNMs, and to explore the influence of the model structure and optimizer parameters on the accuracy of force determination. The methods used are plasma physics, computer simulation, deep learning, and optimization using an improved version of stochastic gradient descent. As a result of research, three NNMs have been developed, which differ in the number of hidden layers and neurons in hidden layers. For training and validation of the NNMs, a data set was generated for an SDO approximated by a cylinder using an autosimilar description of the ion plasma propagation. The data set was obtained for various relative positions and orientations of the object in the process of its removal from an orbit. Using this data set, the NNM parameters were optimized with the supervised learning method. The optimizer and its parameters are selected, providing a small error at the stage of validating learning outcomes. It was found that the accuracy of determining the force depends on the relative position and orientation of the SDO, as well as the architecture of the NNM, and the features of this influence were identified. The approach applied allows us to obtain the possibility of using methods of deep learning to determine the force impact of the IT plume on the SDO. The proposed models provide the accuracy of the force impact determination, which is sufficient for solving the considered class of problems. At the same time, NNM makes it possible to obtain results much faster in comparison with the methods used previously. This fact makes the NNMs promising to use both on-board and in mathematical modeling of missions to remove space debris.
The Contributions of Asian Muslims’ Local Wisdom in the Seloko Adat Jambi for Empowering Social Tolerance
Authors: Badarussyamsi Badarussyamsi , Ermawati Ermawati
Published: December 2022

This article discusses the tolerance values in Seloko Adat Jambi as one of the treasures ofJambi society. Jambi is known as free conflict area and is classified as a plural societyconsisting of various beliefs, ethnic, cultural, and religious schools of thought. The toleranceof the society is inspired by tolerance values in Seloko Adat Jambi. The aims of this study areto explore the values of tolerance in Seloko Adat Jambi and to show that these values areactualized in their social life. This study uses a content analysis method that explores tolerancevalues in Seloko Adat Jambi texts. The findings show that empathy, friendliness, and respectothers are derivative values of tolerance in Seloko Adat Jambi. In addition, the actualization ofthe values of tolerance is manifested in the ethical awareness of people who tend to respectothers, try to prevent conflicts, resolve conflicts appropriately and thoroughly, and obey therules that exist in society. In conclusion, the Jambi people are accustomed to the values oflocal wisdom which are full of values of tolerance and respect for others. All of these thoughtshave shaped them into a society that avoid fanatical, extreme, and hostile attitudes.
Computational Study of 1-(3-Nitrobenzoyloxymethyl)-5-Fluorouracyl Derivatives as Colorectal Cancer Agents
Authors: Mardianingrum Richa , Susilawati Delis , Ruswanto Ruswanto
Published: December 2022

Cancer is one of the chronic diseases with a reasonably high increase at this time. One type of cancer with the highest mortality rate is colorectal cancer. Colorectal cancer is cancer that occurs in the colon and rectum. Based on GLOBOCAN data (2018), cases of colorectal cancer in Indonesia reached 8.6% or 30,017 people and were the second most common cause of death in men and the third in women. The development of cancer drugs to obtain drugs with better activity, lower toxicity, and working more selectively through structural modifications is still being carried out until now. This study aims to determine the pharmacokinetic properties and stable interactions between the thymidylate synthase and one of the 78 derivatives of 1-(3-nitrobenzoiloximethyl)-5-fluorouracyl (NB5FU) by in silico, namely molecular docking, and molecular dynamics simulations. The result shows that the NB5FU78 derivative compounds have better pharmacokinetic properties than NB5FU. Lipinski's rules of five criteria that fill the requirements have a smaller free bond energy value than NB5FU. Based on the results of molecular dynamics simulations carried out for 5 ns, the NB5FU78 derivative has a stable interaction with the thymidylate synthase (TS) receptor with total bond energy of -36.36 kcal/mol.
The Performance and Characterization of Polymeric Inclusion Membranes (PIMs) Containing 2-Nitro Phenyl Octyl Ether as Plasticizer on Phosphate Transport
Authors: Aini Hanifah Nur , Rumhayati Barlah , Fardiyah Qonitah , Wiryawan Adam , Andayani Ulfa , Azzah Anisah Nabilah
Published: December 2022

Polymer Inclusion Membranes (PIMs) have been fabricated for diffusive passive sample layers. A study of various concentrations of plasticizers and characterization of PIM performance on phosphate transport has been carried out. The composition of PIM consisted of cellulose triacetate (CTA) as the base polymer, Aliquot 336-Cl as a carrier, and 2-Nitro phenyl octyl ether (2-NPOE) as a plasticizer. The plasticizer concentration varied between 0 and 10% (w/w). The performance of PIM on phosphate transport was studied with a passive sampler filled with 15 mL 0.1 M NaCl as the internal phase. The passive samplers were deployed into the bulk phase of a phosphate solution of 0.6 mg/L for 0-48 hours. The phosphate concentration in the passive sampler was determined using the visible spectrophotometry method at 691 nm (in the bulk phase) and 710 nm (in the internal phase). PIMs were characterized for stress-strain, contact angle, surface morphology, and cross-section. The sampling rate of phosphate, phosphate time-weighted concentration (CTWA), and accuracy of phosphate measurement was also determined. The results showed that PIM A (0% w/w 2-NPOE) resulted in a sampling rate of 0.0005±0.0002 (L/hour), CTWA 0.09 mg/L, and an accuracy of 28.38%. PIMs B (10% w/w 2-NPOE) resulted in a sampling rate of 0.0003±0.0001 (L/hour), CTWA 0.18 mg/L, and an accuracy of 52.15%. PIMs A and B have a contact angle of 17.02⁰ and 18.71⁰, respectively. It means that these PIMs are hydrophilic membranes. In addition, PIMs B was more elastic than PIMs A, showed by the tensile strength of PIMs B was 31.05 MPa compared with PIMs A's tensile strength (29.01 MPa). PIMs A and B have no pores, as shown by surface morphology using SEM. However, based on the cross-section area, PIMs A showed a break section instead of PIMs B, which indicates that PIMs B is more elastic than PIMs A.
ACOG Bulletin No. 756: Optimizing Support for Breastfeeding as Part of Obstetric Practice
Authors:   Breastfeeding Expert Work Group Committee on Obstetric Practice
Published: December 2022

As reproductive health experts and advocates for women’s health who work in conjunction with other obstetric and pediatric health care providers, obstetrician–gynecologists are uniquely positioned to enable women to achieve their infant feeding goals. Maternity care policies and practices that support breastfeeding are improving nationally; however, more work is needed to ensure all women receive optimal breastfeeding support during prenatal care, during their maternity stay, and after the birth occurs. Enabling women to breastfeed is a public health priority because, on a population level, interruption of lactation is associated with adverse health outcomes for the woman and her child, including higher maternal risks of breast cancer, ovarian cancer, diabetes, hypertension, and heart disease, and greater infant risks of infectious disease, sudden infant death syndrome, and metabolic disease. Contraindications to breastfeeding are few. Most medications and vaccinations are safe for use during breastfeeding, with few exceptions. Breastfeeding confers medical, economic, societal, and environmental advantages; however, each woman is uniquely qualified to make an informed decision surrounding infant feeding. Obstetrician–gynecologists and other obstetric care providers should discuss the medical and nonmedical benefits of breastfeeding with women and families. Because lactation is an integral part of reproductive physiology, all obstetrician–gynecologists and other obstetric care providers should develop and maintain skills in anticipatory guidance, support for normal breastfeeding physiology, and management of common complications of lactation. Obstetrician–gynecologists and other obstetric care providers should support women and encourage policies that enable women to integrate breastfeeding into their daily lives and in the workplace. This Committee Opinion has been revised to include additional guidance for obstetrician–gynecologists and other obstetric care providers to better enable women in unique circumstances to achieve their breastfeeding goals.
Prácticas inclusivas en la educación indígena, el caso de una escuela primaria en Ensenada, Baja California, México
Authors: Solis del Moral Sharon Stephanie , Tinajero Villavicencio María Guadalupe , Cárdenas Juan Páez
Published: December 2022

Hace más de tres décadas, diversos países asumieron el compromiso de desarrollar sistemas educativos inclusivos a partir de los postulados de una “Educación para Todos”, promovidos por organismos internacionales. México no fue la excepción, y aunque sus políticas han sido graduales, la construcción de escuelas inclusivas ha adquirido centralidad; lo cual es un reto, sobre todo, para las escuelas indígenas marcadas por ubicarse en contextos de marginación. Desde un paradigma interpretativo y un enfoque cualitativo, se realizó un estudio de caso etnográfico con el objetivo de construir colectivamente las prácticas inclusivas impulsadas por las 8 personas que conforman el colectivo docente de una escuela indígena de Ensenada, Baja California, México, para poder documentarlas y comprenderlas en su cotidianidad. Para ello, se utilizaron dos técnicas etnográficas, la entrevista al profesorado y la observación in situ en la escuela y en las aulas; se recolectaron los datos durante ocho meses, (agosto de 2019 a marzo de 2020). A través de la técnica de análisis cualitativo de contenido se identificó que el colectivo docente desarrolla prácticas inclusivas demarcadas por sus posibilidades de actuación, que adquieren sentido en su contexto. Los hallazgos refieren acciones como prevenir el ausentismo y procurar la permanencia, sobre todo del alumnado en riesgo de exclusión social; atención del estudiantado con alguna discapacidad y/o necesidades educativas específicas; y adecuaciones en la trayectoria escolar. En las aulas, el profesorado realiza adecuaciones curriculares y ajustes en sus clases en función de sus características individuales, grupales, económicas y de salud. En las conclusiones destaca cómo las prácticas son consideradas como inclusivas en tanto responden a las características y necesidades del contexto situado del estudiantado.