bluuebunny/crossref_metadata_2025 huggingface dataset:
Central effects of ex vivo caffeine-modulated immune cells in the mechanisms of editing depressive-like behavior
Authors: Markova E. V. , Knyazheva M. A.
Published: August 2024

Depression is a serious medical and social problem due to its high prevalence, involvement of people of working age and lack of highly effective therapy. Social stressors contribute to the prevalence of depression. The COVID-19 pandemic and the associated rules of social distancing, military clashes, and a deteriorating economic situation can lead to a painful “breakdown” of socio-biological adaptation mechanisms and contribute to an increase in the prevalence of depressive disorders, which, according to WHO forecasts, may take second place in the world by 2030, which leads to interest in studying this problem and finding new effective approaches to therapy. Decreased cognitive function in depressive disorders is caused by neuroinflammatory and neurodegenerative changes. The latter are predominantly recorded in the hippocampus, numerous changes in the plasticity of which have been observed both in patients with clinical depression and in rodent models of depression. There is also a sufficient amount of data on the significant role of immune cells and their cytokines in depression, including in the development of behavioral phenotype. We have previously shown that spleen cells of depressive-like mice after ex vivo treatment with caffeine, a psychoactive drug with a wide range of immunomodulatory properties, change their functional activity and, after intravenous administration to syngeneic depressive-like recipients, have editing depressive-like behavior effect. The purpose of this work was to investigate the central effects of caffeine-modulated spleen cells in the mechanisms of editing depressive-like behavior. It was found that in depressive-like recipients after transplantation of syngeneic caffeine-modulated splenocytes, there is an increase in the density of neurons in the CA1 and CA3 zones of the hippocampus, accompanied by BDNF level increase in the hippocampus and prefrontal cortex against the background of a decrease of a number of pro-inflammatory (IL-1β, IL-6, IFNγ and TNFα) and increased of anti-inflammatory (IL-10 and IL-4) cytokines in brain structures pathogenetically significant for the state of depression. The mechanisms of the identified structural and functional changes in the recipient’s brain after the caffeine-modulated splenocytes transplantation are discussed, including their possible direct influence, confirmed by visualization of transplanted cells in the brain parenchyma of depressed-like recipients.
Interrelations between iron content and immune dysfunctions in frequently ill children of the Aral Sea Region
Authors: Jiemuratova G. K. , Aripova T. U. , Kamalov Z. S. , Mambetkarimov G. A.
Published: August 2024

The widespread occurrence of immune-dependent diseases and disturbances in iron metabolism, as well as their co-occurrence and the impact of iron deficiency on the immune system, underscore the relevance of this study. Modern data also indicate the involvement of iron in regulating cytokine production and protein synthesis by lymphocytes. In addition to the age-related characteristics of the child’s immune system, a significant factor in the development of inadequate course of the infectious process is the disruption of immune system adaptation, which can be caused by frequent infections, other somatic diseases such as anemia, and environmental factors. The aim of this study is to assess the relationship between iron levels and immune dysfunction in children with frequent acute respiratory diseases living in the Aral Sea region. A total of 127 children, who are native residents living at the epicenter of the ecological crisis, were examined. The children’s ages ranged from 1 to 5 years old. Among them, there were 105 frequently ill children (with 6 or more episodes of acute respiratory infections per year) with iron-deficiency anemia (IDA), and 22 healthy children of the same age. All children underwent clinical examination and standard laboratory tests, including complete blood count, relative content and ratio of T and B lymphocytes, as well as the levels of pro- and anti-inflammatory cytokines (IL-2 and 4) and ferritin in the serum.
According to the results of the conducted research, it was found that among frequently ill children with iron-deficiency anemia (IDA), there is a moderate positive correlation between the relative quantity of T lymphocytes and the hemoglobin level (r = +0.62), as well as a strong positive correlation with the serum iron level (r = +0.78). This indicates a significant influence of iron deficiency on the level of cellular immunity. Clinical data also indicate a higher risk of respiratory infections development in children with IDA compared to the control group. Ferritin, hemoglobin, lymphocytes, and cytokines act as positive regulators of hematopoiesis in IDA conditions and contribute to the compensation of anemia during iron deficiency replenishment.
Analysis of rat jaw bone tissue elemental composition in a model of periodontitis
Authors: Sarkisyan N. G. , Kataeva N. N. , Khokhryakova D. A. , Melikyan A. H. , Оsipova I. M.
Published: August 2024

The elemental composition of jaw bone tissue depends on many external and internal factors affecting the body. The structure of bone tissue directly reflects its ability to restrain inflammation and regenerate after exposure to damaging factors.
The purpose of the study is to study the elemental composition of the rat jaw bone tissue during chronic periodontal inflammatory process. A month later, the individual was removed from the experiment by an overdose of ether to isolate the bone segment under study. Next, the bone tissue sample was studied using atomic emission spectroscopy.
In the studied segment of bone tissue, 67 chemical elements were identified in a quantitative range of up to 10-4 mass percent. The highest mass fraction belongs to the basic elements of bone tissue: calcium, phosphorus, magnesium, sodium, and sulfur. While during the experiment the animals received standard complete feed, which contained proteins, vitamin D close to normal, Ca, P and Se. In the bone tissue sample under study, the quantitative Ca/P ratio was 1.685, which slightly exceeds the optimal one. An increase in this indicator is associated with a decrease in phosphorus content in bone tissue, which can be explained by insufficient daily intake of this element from food, as well as a number of local factors. When the jaw is traumatized during the modeling of periodontitis, an inflammatory process occurs in this area, the experimental animal experiences stress, which leads to demineralization of the tissues of the alveolar process of the jaw, as evidenced by a decrease in the content of phosphorus and selenium in the bone tissue. In addition, elemental analysis showed the presence of foreign elements in the bone tissue, the amount of which corresponds to the range from 0.001% to 0.06%. Basically, these are elements that form simple substances - metals: bismuth, gallium, lead, iridium, titanium, zinc, mercury, molybdenum.
The results of the study can be taken into account when planning and conducting polyetiotropic therapy for inflammatory-dystrophic periodontal diseases in the early stages of their development.
Distribution of the T cell element of the immune system in post-COVID patients with first identified hyperglycemia
Authors: Savchuk K. S. , Ryabova L. V.
Published: August 2024

Post-COVID syndrome combines many adverse outcomes with often new-onset conditions, including type 2 diabetes mellitus (DM). The relevance of the study is the insufficient data on T cell immunity in patients with hyperglycemia after COVID-19. The purpose of this study was to identify the characteristics of T cell immunity in individuals with post-COVID syndrome and newly diagnosed carbohydrate metabolism disorders (CDM) in the post-COVID period. The study included 100 patients (32 men and 68 women) aged from 38 to 70 years (mean age (M±m) was 59.40±8.80 years) with a verified post-COVID-19 condition. All patients were divided into three groups: group 1 – patients with concomitant newly diagnosed impaired glucose tolerance (IGT) in the post-COVID period (prior to SARS-CoV-2 infection, no increase in glycemia was detected according to primary medical documentation) (n = 30), group 2 – patients with concomitant newly diagnosed type 2 diabetes mellitus (n = 30), and group 3 – patients with the development of post-COVID syndrome without hyperglycemia (n = 40). During the study, the following parameters were determined: CD45+, CD3+ (T lymphocytes), CD45+, CD3+, CD4+ (helper inducers), CD45+, CD3+, CD8+ (cytotoxic T lymphocytes), CD45+, CD3+, CD4+, CD25+, CD127- (T regulatory cells), CD45+, CD3+, CD4+, CD25+ (T lymphocytes – early activation), CD45+, CD3+, HLA-DR+ (T lymphocytes – late activation). Infection with SARS-CoV-2 with the subsequent development of post-COVID syndrome and persistent hyperglycemia (IGT, type 2 diabetes) in the post-COVID period was accompanied by a higher level of the total number of T lymphocytes. A study of the T lymphocyte population revealed changes in the subpopulation composition. In the group of patients with CDM, a significant increase in T cytotoxic and T regulatory cells was noted. More pronounced changes in the subpopulation composition were identified in the group of patients with newly diagnosed type 2 diabetes in the post-COVID period: an increase in the relative and absolute numbers of T helper cells and T cells of late activation of lymphocytes. Disorders of carbohydrate metabolism associated with COVID-19 are accompanied by changes in the subpopulation composition of T lymphocytes. In individuals with newly diagnosed type 2 diabetes in the post-COVID period, hyperactivation of the T cell component of the immune system was revealed. Heterogeneous data were obtained in individuals with newly diagnosed impaired glucose tolerance, which requires further study of this group of patients.
Effect of interval hypoxytherapy on the immune status of hypertensive patients
Authors: Borukaeva I. Kh. , Abazova Z. Kh. , Ivanov A. B. , Shkhagumov K. Yu. , Shavaeva F. V. , Molov A. A. , Tkhabisimova I. K. , Kipkeeva T. B. , Shokueva A. G. , Ashagre S. M. , Ligidova D. R. , Kugotov A. M.
Published: August 2024

In recent years, the role of sluggish nonspecific inflammation in the pathogenesis of hypertension has been proven. Oxidative stress that develops in hypertension leads to damage of endothelial glycocalyx with impaired barrier and adaptive functions of endothelium. Activation of transcription factor NF-kB leads to increased synthesis of free oxygen radicals, adhesion molecules (VCAM-1, ICAM-1, P-selectin, E-selectin) and proinflammatory cytokines (TNFα, IL-1, IL-6), triggering the inflammatory process in the endothelium. Modern antihypertensive drugs, affecting various pathogenetic mechanisms of arterial hypertension development, do not fully affect the immune component of arterial hypertension. Therefore, the search for various methods affecting the immunologic reactivity of hypertensive patients remains relevant in our time.
The aim of the study was to reveal the effect of interval hypoxytherapy on the state of immunologic reactivity of patients with hypertension stage I.
One hundred seventy male patients of 30-45 years old (mean age 38.36±1.64 years) with hypertension stage I (n = 170) who underwent combined treatment including drug therapy and normobaric interval hypoxic therapy in hypoxia-normoxia mode (oxygen content in hypoxic gas mixture was 20.9%) were examined. Indices of redox status and immunologic reactivity before and after interval hypoxytherapy were studied.
Having a significant antioxidant effect, interval hypoxytherapy led to the subsidence of oxidative stress, which was indicated by an increase in the activity of superoxide dismutase and glutathione peroxidase in blood erythrocytes and a decrease in the content of malonic dialdehyde in blood as a result of a decrease in the generation of free oxygen radicals and suppression of lipid peroxidation processes. Interval hypoxytherapy resulted in a statistically significant increase in the initially decreased content of CD3+T lymphocytes (p 0.05), CD3+CD4+T lymphocytes (p 0.02), CD3+CD8+T lymphocytes (p 0.02). Initially increased number of B-lymphocytes CD19+, CD16+ lymphocytes, CD95+ lymphocytes significantly decreased. An important result of interval hypoxytherapy was a pronounced anti-inflammatory effect: statistically significant decrease in the content of pro-inflammatory interleukins IL-1β (p 0.02), IL-6 (p 0.01) and increase in the content of anti-inflammatory cytokines IL-4 (p 0.005) and IL-10 (p 0.005), which led to the subsidence of sluggish nonspecific inflammation.
Suppression of oxidative stress and normalization of immunological reactivity of hypertensive patients after interval hypoxytherapy led to the subsidence of sluggish nonspecific inflammation, reduction of endothelial dysfunction and restoration of the structure and tone of the vascular wall with a decrease in blood pressure and improvement of the clinical course of hypertension.
Transfusion of allogenic cord blood to patients with multiple myeloma: safety analysis and influence on the immunophenotype of blood lymphocytes in the early period
Authors: Tyumina O. V. , Davydkin I. L. , Gritsenko T. A. , Trusova L. M. , Tyumin I. V. , Bogush V. V. , Sokolova V. V. , Gusarova E. A. , Chibashova A. V. , Limareva L. V.
Published: August 2024

Severe immune dysfunction occurs in the majority of cancer patients. One of the methods for overcoming immune disorders is transplantation of peripheral blood hematopoietic stem cells, both autologous and allogeneic, and transfusion of allogeneic natural killer cells (NK cells). Umbilical cord blood is a known source of not only hematopoietic stem cells (HSCs) but also NK cells, characterized by the rapid availability of blood samples from public cord blood banks. Purpose of the study: to analyze the safety of simultaneous transfusion of three allogeneic cord blood to patients with relapsed/refractory multiple myeloma in the early period (7 days after administration), and also to study the response of subpopulations of peripheral blood lymphocytes of patients to this intervention.
The pilot study included 10 patients (7 men and 3 women) with relapsed/refractory multiple myeloma who had previously received more than 3 lines of therapy. The age of the patients was 59.4±3.4 years; all of them received a single transfusion of three allogeneic samples of umbilical cord blood with an average dose of leukocytes of 60.50±8.2 × 108 (NK cells – 4.36±1.2 × 108) per one patient. A total of 30 samples of umbilical cord blood, alloreactive for KIR receptors of the receptor-ligand type, were transfused. The selection of HSCs concentrates was carried out in the umbilical cord blood bank of the Dynasty Medical Center. Before transfusion of umbilical cord blood, patients received cyclophosphamide 5 mg/kg. After transfusion, patients received five subcutaneous injections of IL-2 (roncoleukin) in the amount of 1 million units per day. Observation at the time of assessment of preliminary results: 7 days after transfusion. Analysis of the immunophenotype of patient lymphocytes was studied twice: on the day of transfusion before the start of the protocol and 7 days after transfusion of umbilical cord blood.
No early adverse reactions to transfusions were observed.
Simultaneous transfusion of three allogeneic cord blood to patients with relapsed/refractory multiple myeloma is a safe procedure. There are no adverse reactions, serious adverse events, or significant reactions/changes in the immunophenotype of patient lymphocytes in the early observation period within 7 days after the intervention.
DETERMINANTS OF TRANSFER PRICING FROM NON CYCLICAL'S AND INDUSTRIAL PERSPECTIVES
Authors: Lestari Alicia , Bwarleling Theresia Hesti
Published: August 2024

The aims examine the effect of bonus mechanism, effective tax rate, and debt covenant on transfer pricing in consumer non cyclicals and industrial sector companies on the Indonesia Stock Exchange in 2020-2022. The sample in this study used purposive sampling method and obtained 16 companies listed in 2020-2022 period. The analysis method used in quantitative method with multiple linear regression analysis and using SPSS 26 software. This study uses secondary data in the form of financial report obtained from www.idx.co.id. The result of multiple linear regression is that the variable of bonus mechanism and effective tax rate has no significant effect on transfer pricing, while debt covenant has positive and significant effect on transfer pricing. The variable of bonus mechanism and effective tax rate have not been proven to give significant influence. For this reason, it is expected that future research can provide result and use more appropriate proxies for each independent variable in this study.
Cover of Journal
Authors: Journal Cover
Published: August 2024

Cover of Journal
Table of Contents
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Published: August 2024

Table Of Contents
The Effect Of Adding Natural Ingredients To Artificial Feeding On The Level Of Color Brightness Of Carp (Cyprinus carpio Linn)
Authors: Manullang Helentina Mariance , Siregar Budiman , Gea Sadarman Kristian
Published: August 2024

The Effect of Adding Natural Ingredients to Artificial Feed on the Color Brightness Level of Goldfish (Cyprinus carpio Linn). This research aims to determine the effect of adding natural ingredients to artificial feed on the level of color brightness of goldfish (Cyprinus carpio Linn), and the growth rate and survival rate of the test fish. The method used in this research is an experimental method using a Completely Randomized Design (CRD) consisting of 4 treatments and 3 replications with a feeding frequency of three times per day with a percentage of 5% of the body weight of the test fish, a natural ingredient used in making artificial feed. These are pumpkin flour (Cucurbita moschata), mangosteen rind flour (Garcinia mangostana L), and carrot flour (Daucus carota L) with the same dose in each treatment, namely 25% of 1 kg of feed. Based on the results of variance analysis, the brightness level of goldfish color has a very real influence. The highest increase in the color of the test fish was obtained in treatment A, pumpkin flour, amounting to (1.37) on the Toca color finder scale (from pale orange to dark orange), followed by the second highest in treatment C, carrot flour, amounting to (1.2), treatment B flour. Mangosteen peel was in third position with an increase in color of (0.94) and the lowest increase in color change occurred in treatment D (control = without the addition of natural ingredients) of 0.7. However, absolute weight and length growth did not have a real influence. The overall graduation rate is 87.49%. The average water quality parameters are temperature 26-29oC, pH 7.5-7.9 and ammonia 0.25 ppm.
The Influence Of Product Quality And Product Design On Consumer Purchasing Decisions On CV. New Jaya Blessings Medan
Authors: Fadhylla Ika , Harahap Ahmad Taufiq , Firah Al
Published: August 2024

This research aims to find outthe influence of product quality and product design on consumer purchasing decisions at CV. Thanks to Jaya Baru Medan.This type of research uses quantitative research. The population of this study was 100 employees with a sample of 50 employees. The sampling technique uses the Slovin formula. Data analysis using multiple linear regression, the following results were obtained. HThe results of this research illustrate that there is a significant influence between product quality on consumer purchasing decisions at CV. Thanks to Jaya Baru Medan where the value of t > t table is 1.678 (8.498 > 1.678) in the positive direction. So Ha is accepted and H0 is rejected so it can be concluded that the product quality variable partially has a positive and significant effect on consumer purchasing decisions at CV. Thanks to Jaya Baru Medan. There is a significant influence between product design on consumer purchasing decisions at CV. Thanks to Jaya Baru Medan where the calculated t value < t table 1.678 (-1.637 < 1.678). So Ha is rejected and H0 is accepted so it can be concluded that partial product design has no effect and is not significant with a negative value on consumer purchasing decisions on CV. Thanks to Jaya Baru Medan.There isproduct quality and product design on consumer purchasing decisions at CV. Thanks to Jaya Baru Medan.
The Influence Of Product Differentiation And Price Discounts On Purchasing Decisions At PT. Hindo Medan
Authors: Irawan Dhanni Delyan , Asnawi Muhammad , Firah Al
Published: August 2024

This study aims to determine and analyze the effect of product differentiation and price discounts on purchasing decisions at PT Hindo Medan. There are still people who think that this store is quite expensive for the price of each product. The product differentiation found in the company is considered to be less effective with other companies and does not have a significant difference. Price Discounts provided are still relatively low compared to discounts from other competing products and consumers cannot decide to shop at this store. This study uses quantitative data types and multiple regression analysis to obtain answers to the research hypothesis, the sample size is 71 respondents, with the sampling technique being a saturated sample. The results of the t test analysis show that there is an effect of product differentiation on purchasing decisions at PT. Hindo Medan can be seen from tcount> ttabel (2.384> 1.667) with a significance of 0.000 <0.05. Price Discount on Purchasing Decisions at PT Hindo Medan can be seen from tcount> ttabel (3,865>1,667) with a significance of 0.001 <0.05 F test together between the Effect of Product Differentiation and Price Discount on Purchasing Decisions at PT Hindo Medan. obtained the value of Fcount> Ftabel (13.365> 3.13) which shows simultaneously the Effect of Product Differentiation and Price Discount on Purchasing Decisions at PT. Hindo Medan It can be seen from the R-square result of 0.282 or 28.2% which indicates that around 28.2 Purchasing Decision variables (Y) can be explained by the Product Differentiation variables (X1 ) and Price Discount (X ).2
Analysis of Performance and Security in Modern Computer Networks
Authors: Satria Welnof
Published: August 2024

Computer networks have become the cornerstone of communication and data transfer in today's digital era. This article provides an in-depth examination of various critical aspects of computer networks, including network architecture, protocols, hardware, and the issues surrounding security and performance. Emphasizing the significance of robust network design, the study evaluates different topologies, such as star, bus, ring, and mesh, and their impact on network efficiency and reliability. Furthermore, it explores essential network protocols like TCP/IP, UDP, and HTTP/HTTPS, highlighting their roles in ensuring efficient and reliable data communication. The analysis extends to modern hardware components, such as routers, switches, and security devices like firewalls and IDS/IPS, which are integral to network management. Additionally, the article delves into the latest networking technologies, including 5G, the Internet of Things (IoT), and cloud computing, discussing their transformative potential and the associated challenges in their deployment and management. This comprehensive overview aims to provide valuable insights for practitioners and researchers in developing innovative and effective solutions for secure and high-performance networks.
Entropy and Stability in Fuzzy Control Systems-A Theoretical Analysis
Authors: N Yogeesh
Published: August 2024

This paper studies the theoretical relationship between entropy and stability in fuzzy control systems. Fuzzy entropy is employed to measure the uncertainty or fuzziness in the system and its influence on unstable behaviour of systems. Accomplishing this through mathematics formulations and derivations, we prove that fuzzy control systems of lower entropy are more stable. This document is authenticated by a well-known practical example related to the temperature regulation system in which we calculate entropy values and determine stability using Lyapunov's direct method. This indicates that the reduction of entropy is critical to improving the stability and reliability in fuzzy control systems. This study brings a new guideline for stability analysis and suggests useful thoughts to design the higher stable fuzzy systems.
Transport support and prospects for the development of the freight frame on the Moscow Railway
Authors: Tanaev V. F.
Published: August 2024

Talking points for the speech by the Head of Moscow Railway V. F. Tanaev at the III Conference of the Association of Rectors of Transport Universities BRICS as part of the events of the BRICS Business Council Subgroup on Transport and Logistics. June 10, 20241.
LA APLICACIÓN ADMINISTRATIVA DIRECTA DEL DERECHO COMUNITARIO
Authors: BALLESTEROS MOFFA LUIS ÁNGEL
Published: August 2024

Pone de manifiesto una de las piezas básicas del Derecho Administrativo europeo, como es la teoría del acto administrativo. La presencia de esta teoría en el sistema comunitario desde un punto de vista más bien práctico, aporta a la actividad de las instituciones comunitarias una nueva dimensión, distinta de su función normativa con las clásicas fuentes de base o ejecución.
POLÍTICAS DE DESCENTRALIZACIÓN EN MARRUECOS: EL PROCESO DE REGIONALIZACIÓN
Authors: OJEDA GARCÍA RAQUEL
Published: August 2024

Análisis de la política de construcción de la región de Marruecos desde que alcanzó su independencia. En un primer bloque se ubica la región en las décadas de los sesenta, setenta y ochenta al lado de la política de planificación. Se pretende estudiar los precedentes de la región económica de 1971, las razones de su fracaso como institución, el impulso dado a la regionalización tras el discurso de Hassan II en 1984 y las propuestas que se plantearon para una futura región.
Zakat dan Pajak sebagai Lembaga Keuangan Publik
Authors: Fadhilah Fitri , Viky Muhammad , Sabrina Kelvin Putri , Septyani Sri Devi , Ridwan Mohammad , Salembudi P Altus
Published: August 2024

Integration of zakat and tax as public financial institutions. Zakat and tax have different purposes and functions, but both have an important role in national financial management. However, there are problems in the management of zakat and tax, such as inconsistency and lack of public understanding of the difference between zakat and tax. To overcome these problems, steps are needed such as raising public awareness about the difference between zakat and tax through education and awareness campaigns. In addition, it is also important to raise the awareness of the government and financial institutions about the difference between zakat and tax through training and education. Analysis of zakat and tax integration can be done through theoretical, empirical, and qualitative approaches. Through this analysis, effective solutions can be found to overcome the problems of zakat and tax integration, such as strengthening education and socialization, harmonizing regulations, and increasing transparency and accountability in the management of zakat and taxes. With the implementation of the right solution, it is expected that the integration of zakat and tax can provide benefits for individuals, society, and the state. Zakat can help improve the welfare of disadvantaged communities, while taxes can be a source of funding for national development. In order to realize effective integration, it is necessary to have cooperation and synergy between the government, zakat institutions, and the community.
Studi Efektivitas Penerapan Kurikulum Merdeka Belajar di SMA Islam Athirah 1 Makassar
Authors: Yusran Yusran , Markani Markani
Published: August 2024

This research aims to analyze and also develop the effectiveness of implementing the curriculum they study at SMA Islam Athirah 1 Makassar. The independent learning curriculum is a new policy in the world of education in Indonesia which gives freedom to each educational unit in managing and developing a curriculum that suits the needs and characteristics of students. By taking this approach, we will explore the opinions of each student teacher and also the school principal regarding the implementation of the independent learning curriculum at SMA Islam Athirah 1 Makassar. The data collected in this article was through observation and interviews. The independent learning curriculum at SMA Islam Athirah 1 Makassar will have a positive impact in increasing creativity, independence and interest in learning for students at SMA Islam Athirah 1 Makassar.
Tipos de contenções ortodônticas: revisão de literatura
Authors: Costa Fernanda Drielly Amorim
Published: August 2024

Contenções ortodônticas são importantes para a manutenção dos resultados pós conclusão do tratamento ortodôntico. O não uso das contenções ao final do tratamento convencional pode alterar os resultados desejados. Não usar as contenções, pode acarretar consequências negativas na arcada dentária, podendo causar abertura dos elementos dentários, movimentos e desalinhamentos dos dentes, afetando a estética, sistema funcional, sociais, psicológicos e financeiros ao paciente. Este trabalho tem o intuito de mostrar aos cirurgiões-dentistas os tipos de contenções disponíveis na odontologia, relatar todas as indicações e fatores negativos ao tratamento quando não se faz o uso. Esse trabalho é uma revisão de literatura baseada em pesquisas através de artigos em língua portuguesa e língua inglesa através dos sites PubMed, Google Acadêmico e SciELO, utilizando as palavras chaves: contenção fixa, contenção removível e ortodontia. Conclui-se que o mercado tem vários aparelhos ortodôntico e a escolha de qual aparelho ser utilizado, deve-se levar em consideração, necessidade estética do paciente, as limitações de higienização, a oclusão inicial do tratamento ortodôntico e a cooperação do paciente. Após a correta avaliação e escolha de qual tipo de contenção a ser utilizada esperamos uma boa estabilidade e resultado pós-ortodontia.
A utilização de mini-implantes com finalidade ortodôntica: revisão de literatura
Authors: Silva Adhara Roberta Campos Moreira da
Published: August 2024

A utilização de mini-implantes tem se tornado cada vez mais uma fácil indicação para obtenção de ancoragem em tratamentos ortodônticos, sendo consenso entre ortodontistas que sua utilização significou um dos avanços mais relevantes no que tange a ancoragem ortodôntica. Os mini-implantes vêm tornando os tratamentos mais simples e reduzindo de maneira considerável os riscos e efeitos indesejados em relação aos tratamentos convencionais, especialmente por seu tamanho e variedade que oferecem ao ortodontista diversas possibilidades de instalação, promovendo benefícios tanto para o paciente quanto para o profissional, até mesmo em relação ao custo-benefício. Portanto, este trabalho teve como objetivo a utilização dos mini-implantes ortodônticos, analisando: vantagens, desvantagens, aplicações clínicas e indicações. Para isto foi conduzida uma extensa busca textual em: livros, teses, dissertações, bem como; artigos indexados nas bases de dados como: PubMed, SciELO, Google Acadêmico, Medline, Lilacs e BBO. Concluiu-se que, os mini-implantes são eficientes como dispositivos de ancoragem esquelética permitindo mecânicas dentárias complexas, de maneira a minimizar efeitos indesejáveis nos elementos dentários adjacentes aos movimentos.
HUBUNGAN PENGETAHUAN, SIKAP DAN PERILAKU PERSONAL HYGIENE TERHADAP KEPUTIHAN PADA SISWI KELAS XII DI SEKOLAH MENENGAH ATAS SWASTA HARAPAN MEKAR MEDAN
Authors: Gustina Jessi , Apriani Riny , Syahna Syahfira Ananda , Shaimah Rahmi
Published: August 2024

Pemahaman tentang kesehatan reproduksi sangat penting bagi wanita, terutama dalam hal keputihan, agar mereka tahu bagaimana cara mengatasinya dan memahami dampaknya. Penelitian ini bertujuan untuk mengevaluasi hubungan antara pengetahuan, sikap, dan perilaku personal hygiene dengan kejadian keputihan pada siswi. Penelitian ini menggunakan metode kualitatif dan dilakukan di SMA Harapan Mekar Medan. Populasi penelitian mencakup seluruh siswi kelas XII,, teknik pengambilan sampel yang digunakan adalah Total Sampling sebanyak 33 orang. Data dianalisis menggunakan analisis univariat dan bivariat dengan uji chi-square, pada tingkat kepercayaan 95% α=0,05. Hasil penelitian mengungkapkan bahwa yang berhubungan dengan keputihan meliputi pengetahuan (p=0,005), sikap (p=0,016), dan perilaku (p=0,005). Disarankan kepada siswi agar membersihkan area genital dengan cara yang benar, yaitu dengan mengusap dari depan vagina ke arah belakang anus.
Analyzing the Strengths, Weaknesses, Opportunities, and Threats (SWOT) of Plastic Waste Management in Cameroon
Authors: NGEH Henry NGEH , TEMBO Florence MUTALE , WALDE Zakari
Published: August 2024

Over the years, there has been an increase in the production and consumption of plastic materials, basically due to population growth and urbanization. This has resulted in a plastic pollution crisis worldwide, especially in developing countries. In addressing this plastic pollution problem, a number of studies have so far been carried out in line with plastic waste management. However, very few studies, especially in Cameroon, have been published on the strengths, weaknesses, opportunities, and threats (SWOT) of plastic waste management systems. This study conducted a comprehensive SWOT analysis with the purpose of providing understanding into the current plastic waste management (PWM) situation in Cameroon, and to propose enhancement strategies. The data used for the analysis were obtained from a number of sources including government reports, relevant regulations, and policies, peered-reviewed literature, and questionnaires. The study revealed key strengths and opportunities which included available policies, the presence of recycling companies, circular economy potential, and research institutions as well as weaknesses and threats such as ineffective enforcement and implementation policies, absence of a separate collection system, inadequate waste management infrastructure, inadequate financial and technical capacity, the countries geographical position, lack of public interest and participation and population growth and urbanization. Based on the SWOT analysis, a number of strategies were proposed, that is, promulgate policies and ensure strict implementation, set up separate plastic waste collection systems and adopt a national circular economy action plan for plastics. These would be useful in enhancing the current PWM system in Cameroon.
Compacted Care Beyond the Clinic: Designing and Implementing a Portable Dental Unit (PDU) for Remote and Mobile Services
Authors: Taha Al-Taha Younus Jasim , Al-Bahar Karam Hussein Jasim , Al-Hatab Marwa Mawfaq Mohamedsheet
Published: August 2024

For the sake of all those who need dental care in various places, this article presents the rationale for designing and implementing a portable dental unit and finding new and more modern ways to manufacture and evaluate it as well. This device gives priority to durability, portability of the device in different work environments, infection control, and safety. The basic components include, but are not limited to, the air pressure system, the water tank, the Arduino microcontroller to control and manage the pressure, the electrical valves and filters that are subject to international standards, the foot switch, and the device’s control panel. The handpiece assembly in this dental unit, which includes the electric motor handle, the triple syringe, the high-speed turbine, and the low-speed turbine, allows for a variety of dental treatments. The effectiveness of the dental unit was confirmed through its experiment by specialists at Al Noor University in May 2023. Dr. Al Qubais Al Assaf, who supervised the examination, confirmed the effectiveness of the unit in delivering water and compressed air, in addition to its successful design, the ease of carrying and transporting the device, and the ease of its installation, in addition to its durability and resistance to aging Infection and protective functions. Dr. Al-Assaf also spoke about the importance of the mobile dental unit to provide dental care in remote areas or in cases where individuals cannot reach scientific clinics.
Analisis Prediksi Kelulusan Mahasiswa Universitas Sultan Ageng Tirtayasa Menggunakan Algoritma Machine Learning dan Feature Selection
Authors: Sukarna Royan Habibie , Holilah Holilah , Damyati Fitri , Hilman Mohamad
Published: August 2024

The KNN algorithm with feature selection achieved the highest accuracy of 74.44% and an Area Under the Curve (AUC) of 0.8212. This model showed a balanced accuracy improvement compared to its performance using the dataset with complete features, which had an accuracy of 72.83% and an AUC of 0.8071. Similarly, the Random Forest model with feature selection showed an accuracy of 72.00% and an AUC of 0.7741, compared to an accuracy of 70.52% and an AUC of 0.7672 with all features. The SVM model with feature selection also improved, reaching an accuracy of 72.28% and an AUC of 0.7812, compared to an accuracy of 69.80% and an AUC of 0.774 with all features. Logistic Regression showed minimal change, with an accuracy of 69.14% and an AUC of 0.7644 after feature selection, compared to an accuracy of 69.25% and an AUC of 0.7645 with all features.
LA TRIBUTACIÓN DE LAS PLUSVALÍAS INMOBILIARIAS: PRINCIPIO DE CAPACIDAD ECONÓMICA E INFLACIÓN
Authors:   Universidad de Alicante, Martínez Muñoz Yolanda
Published: August 2024

La tributación de las plusvalías inmobiliarias ha sido objeto de un diverso tratamiento jurisprudencial dependiendo del tributo de que se trate y de su posición en el conjunto del sistema tributario. El Tribunal Constitucional exige que se graven plusvalías reales y no monetarias en el Impuesto sobre el Incremento de Valor de los Terrenos de Naturaleza Urbana, e ignora posteriormente los efectos de la inflación sobre las plusvalías inmobiliarias en el Impuesto sobre la Renta de las Personas Físicas. La cuestión es si el principio constitucional de capacidad económica debe interpretarse como capacidad económica real o nominal para garantizar la justicia tributaria. Este trabajo aborda dicha problemática y propone que el legislador tributario contemple el problema de la inflación con el objetivo de salvaguardar el principio de capacidad económica.
Responsivitas Aparatur Dalam Pengelolaan Pengaduan Pelayanan Publik Di Dinas Pekerjaan Umum Dan Penataan Ruang Kabupaten Bungo Provinsi Jambi
Authors: Afrilla Zilfaa , Alhadi Zikri
Published: August 2024

Penelitian bertujuan guna mengkaji lebih lanjut responsivitas aparatur dalam pengelolaan pengaduan pelayanan publik di Dinass Pekerjaan Umum dan Penataan Ruang Kabupaten Bungo Provinsi Jambi. Penelitian ini menggunakan motode kulitatif dengan pendekatan deskriptif. Lokasi penelitian adalah di Jl. RM Thaher No 1 ,kantor Dinas Pekerjaan Umum dan Penataan Ruang Kabupaten Bungo Provinsi Jambi. Informan ditentuan dengan teknik purpossive sampling. Data di kumpulkan melalui observasi, wawancara, dan dokumentasi. Hasil menunjukan bahwa responsivitas Dinas Pekerjaan Umum dan Penataan Ruang Kabupaten Bungo Provinsi Jambi sudah baik ini terlihat dari teori responsivitas oleh Zeithaml yaitu dengan indikator kemampuan merespon masyarakat, kecepatan melayani, ketepatan melayani, kecermatan melayani, dan ketepatan waktu pelayanan serta hasil penilaian sangat baik yang diberikan oleh Inspektorat Kabupaten Bungo.
Implementasi Program Nagari Bersekolah Di Kabupaten Pesisir Selatan (Studi Komparatif Nagari Painan dan Nagari Pancung Taba)
Authors: Aurel Regil , Mubarak Adil
Published: August 2024

Penelitian ini bertujuan untuk menganalisis implementasi Program Nagari Bersekolah (Pronasa) di Kabupaten Pesisir Selatan dengan membandingkan implementasi di Nagari Painan dan Nagari Pancung Taba. Latar belakang penelitian ini adalah perbedaan hasil implementasi Pronasa antara nagari yang terletak di ibu kota kabupaten yaitu Nagari Painan dan nagari yang jauh dari ibu kota kabupaten yaitu Nagari Pancung Taba. Metode penelitian yang digunakan yaitu penelitian deskriptif dengan pendekatan kualitatif melalui studi komparatif. Data-data yang diperoleh dikumpulkan melalui proses wawancara dan observasi serta dokumentasi. Hasil penelitian menunjukkan bahwa implementasi Pronasa di nagari yang berada di ibu kota kabupaten dan nagari yang jauh dari ibu kota kabupaten sama-sama belum berjalan dengan optimal karena komunikasi dari pembuat kebijakan belum menjangkau semua pihak yang terlibat dalam implementasi Pronasa yang berakibat pada tidak adanya kolaborasi antara sekolah dengan pemerintah nagari.
Effectiveness Of Land and Building Tax Collection by Villages in Sukaraja Sub-District
Authors: Arsyu Muhammad Ilham Effendi , Purwanti Dian , Nur Tuah
Published: August 2024

Sukaraja Sub-district is still less effective in carrying out the collection of PBB, this is in accordance with what is conveyed by Duncan who explains that, effectiveness comes from the word effective, namely a job is said to be effective if the job can achieve the goals or objectives that have been determined and can be completed on time in accordance with the plan that has been set. The research method used in this research is qualitative research method, which aims to reveal qualitative information so that it emphasises more on process and meaning issues by describing a problem. The achievement of taxpayer goals is measured by the achievement of tax assessment, the obedience of the community to pay taxes and the timeliness of the community to pay taxes. Both according to the agency and the community, the achievement of taxpayer goals by the Village in Sukaraja Sub-district, Sukabumi District is still less effective. Adaptation in Sukaraja Sub-district is still not effective because adaptation by developing strategies is just in process.
Uso de las tecnologías de la información y la comunicación para reducir el desperdicio de alimentos
Authors: Calzada Gento María , Alonso Esteban Jose Ignacio , Mesias Garcia Marta
Published: August 2024

La cadena de suministro de alimentos ha mostrado ciertas deficiencias en cuanto al control y prevención del desperdicio de alimentos, debido principalmente a la sobreproducción, la falta de conciencia y compromiso social y la mala coordinación entre los diferentes niveles de la cadena alimentaria. Este hecho está provocando múltiples problemas ambientales relacionados con la emisión de gases de efecto invernadero y pérdidas económicas y sociales. El desarrollo de las Tecnologías de la Información y la Comunicación (TIC) en la actual era digital (Industria 4.0) contribuye a una mayor trazabilidad de los productos alimentarios, a la obtención de alimentos más seguros y de mayor calidad y de sistemas alimentarios sostenibles y altamente productivos. El uso de las TIC, junto con los cambios en los hábitos de consumo, la gestión de residuos y las nuevas leyes gubernamentales, son clave para abordar de manera integral la prevención de las pérdidas y el desperdicio de alimentos. El objetivo de este trabajo es realizar una revisión bibliográfica sobre el uso de las TIC como mejora tecnológica aplicada en el sector alimentario para ayudar a solucionar el problema del desperdicio en todas las etapas de la cadena alimentaria, “de la granja a la mesa”.
Interferencias lingüísticas en el aprendizaje de portugués como segunda lengua: Un estudio exploratorio con hablantes de español
Authors: Briceño Nuñez Chess Emmanuel
Published: August 2024

Este estudio explora las interferencias lingüísticas que experimentan los hablantes de español al aprender portugués como segunda lengua. Se realizó un estudio exploratorio con 50 estudiantes de portugués como segunda lengua. Se utilizó un cuestionario y entrevistas para recopilar datos sobre cinco categorías de interferencias: transferencia de la lengua materna, falsos amigos, diferencias gramaticales, fonética y pronunciación, y aspectos culturales y contextuales. Se encontraron interferencias significativas en todas las categorías analizadas. La transferencia de la lengua materna fue la interferencia más prevalente, seguida por los falsos amigos y las diferencias gramaticales. Las diferencias fonéticas y de pronunciación también fueron un desafío para los estudiantes, al igual que las diferencias culturales y contextuales. Las interferencias lingüísticas tienen un impacto significativo en el aprendizaje del portugués como segunda lengua para hablantes de español. Los profesores deben ser conscientes de estas interferencias y adaptar sus estrategias de enseñanza para abordarlas de manera efectiva. Se necesitan más investigaciones para comprender mejor las interferencias lingüísticas en este contexto y desarrollar estrategias de enseñanza más efectivas.
Consumo de drogas y la personalidad de los adolescentes en una comunidad terapéutica
Authors: Tubay Máximo , Reategui Zambrano Yomira Katiuska , Vásconez Mejía Yessenia Jakeline , Córdova Valencia Shirley Vanessa , Moran Jiménez Jenniffer Lisbeth
Published: August 2024

El consumo de sustancias perjudiciales es un problema para las familias y sociedad en general, ya que esta adicción es la causante de problemas que desembocan en disfunciones familiares, con las respectivas consecuencias como: violencia, pérdida deaños escolares, suicidios, accidentes de tránsito y un correcto desarrollo de la personalidad de los adolescentes. En esta investigación se identificó la incidencia de la drogodependencia en el desarrollo de la personalidad de los pacientes jóvenes de la “Comunidad Terapéutica Amor al Prójimo”, relacionando las consecuencias del consumo de drogas en el desarrollo de la personalidad en los adolescentes. El presente trabajo investigativo es de tipo cuali-cuantitativo transversal: cuantitativo porque se obtuvo datosde cantidad mediante la aplicación de encuesta hacia los pacientes, familiares y profesionales investigados y cualitativos debido a que se compara la importancia de la participación familiar en el proceso de rehabilitación de la salud mental de los pacientes.La mayor parte de encuestados corroboraron que el consumo de sustancias psicoactivas limita el fortalecimiento de las relaciones con sus familiares, disminuyendo su razonamiento lógico al estar bajo los efectos de este tipo de sustancias, perdiendo el control y el acto de voluntad.