bluuebunny/crossref_metadata_2025 huggingface dataset:
Differences in Electroencephalography Power Levels between Poor and Good Performance in Attentional Tasks
Authors: Matsuo Moemi , Higuchi Takashi , Ichibakase Taiyo , Suyama Hikaru , Takahara Runa , Nakamura Masatoshi
Published: May 2024

Decreased attentional function causes problems in daily life. However, a quick and easy evaluation method of attentional function has not yet been developed. Therefore, we are searching for a method to evaluate attentional function easily and quickly. This study aimed to collect basic data on the features of electroencephalography (EEG) during attention tasks to develop a new method for evaluating attentional function using EEG. Twenty healthy young adults participated; we examined cerebral activity during a Clinical Assessment for Attention using portable EEG devices. The Mann–Whitney U test was performed to assess differences in power levels of EEG during tasks between the low- and high-attention groups. The findings revealed that the high-attention group showed significantly higher EEG power levels in the δ wave of L-temporal and bilateral parietal lobes, as well as in the β and γ waves of the R-occipital lobe, than did the low-attention group during digit-forward, whereas the high-attention group showed significantly higher EEG power levels in the θ wave of R-frontal and the α wave of bilateral frontal lobes during digit-backward. Notably, lower θ, α, and β bands of the right hemisphere found in the low-attention group may be key elements to detect attentional deficit.
The Epistemic Limits of Impactful Dreams: Metacognition, Metaphoricity, and Sublime Feeling
Authors: Kuiken Don
Published: May 2024

Taxonomic studies of dreams that continue to influence the dreamer’s thoughts and feelings after awakening have distinguished three types of impactful dreams: nightmares, existential dreams, and transcendent dreams. Of these, existential dreams and transcendent dreams are characterized by recurrent metacognitive appraisal of the epistemic tension between complementary (a) metaphoric (A “is” B) assertions and (b) literal (A “is not” B) assertions. Metacognitive appraisal of such complementary metaphoric and literal assertions is detectable as the felt sense of inexpressible realizations. The poesy of such inexpressible realizations depends upon the juxtaposition of a metaphoric topic and vehicle that are both “semantically dense” but at an abstract level “distant” from each other. The result is “emergence” of attributes of the metaphoric vehicle that are sufficiently abstract to be attributes also of the metaphoric topic. The cumulative effect of successive metaphoric/literal categorical transformations produces a higher-level form of metacognition that is consistent with a neo-Kantian account of sublime feeling. Sublime feeling occurs as either sublime disquietude (existential dreams) or as sublime enthrallment (transcendent dreams). The aftereffects of these two dream types are thematically iterative “living metaphors” that have abstract (but not “totalizing”) ontological import.
Self-Determination Theory and Workplace Outcomes: A Conceptual Review and Future Research Directions
Authors: McAnally Kaylyn , Hagger Martin S.
Published: May 2024

Adaptive workplace outcomes, such as employee work engagement, job performance, and satisfaction are positively associated with physical and psychological well-being, while maladaptive workplace outcomes, including work-related disengagement, dissatisfaction, stress, boredom, fatigue, and burnout, are negatively associated with well-being. Researchers have applied self-determination theory to identify key motivational correlates of these adaptive work-related determinants and outcomes. Research applying the theory has consistently indicated that autonomous forms of motivation and basic psychological need satisfaction are related to better employee performance, satisfaction, and engagement, while controlled forms of motivation and need frustration are associated with increased employee burnout and turnover. Forms of motivation have also been shown to mediate relations between need satisfaction and adaptive workplace outcomes. Despite support for these associations, a number of limitations in research in the field have been identified, which place limits on the inferences that can be drawn. Noted limitations encompass an over-reliance on single-occasion, correlational data; few fit-for-purpose tests of theory mechanisms; and a lack of consideration of key moderating variables. In the current conceptual review, we discuss these limitations in turn, with specific reference to examples from the extant research applying the theory in workplace contexts, and provide a series of recommendations we expect will set the agenda for future studies applying the theory in the workplace. Based on our review, we make three key recommendations: we stress the need for studies adopting experimental and longitudinal designs to permit better inferences (i.e., causal and directional), highlight the need for intervention research to explicitly test mediation effects to provide evidence for theory mechanisms, and outline some candidate moderators of theory effects, including workplace context, job type, pay structure, and causality orientations. We expect these recommendations to set an agenda for future research applying self-determination theory in workplace contexts with a view to filling the current evidence gaps and improving evidential quality.
Effects of Developmental Timing on Cognitive and Behavioral Profiles in Fetal Alcohol Spectrum Disorder: Considerations for Education
Authors: Felgueras Nerea , López-Díaz José María , Garrote Inmaculada
Published: May 2024

Associations and families demand the need to raise awareness of the implications in the cognitive and behavioral development of children with Fetal Alcohol Spectrum Disorder (FASD) that affect their learning and school participation. This study aims to generate a profile of executive and behavioral functioning in children and adolescents diagnosed with FASD. A probabilistic sampling by clusters (associations for individuals with FASD) is applied. The sample is composed of 66 families from three associations. The BRIEF-2 and SENA tests were administered to assess executive and behavioral functioning domains. Data analysis found that the executive and behavioral functioning profile of individuals with FASD varies with age, with greater impairment in middle and late adolescence. Likewise, the domain of executive functioning most affected in any of the developmental stages is working memory. Finally, cognitive impairment in the executive functioning domains has a direct impact on the social and adaptive functioning of people with FASD.
Self-Esteem and Risk Behaviours in Adolescents: A Systematic Review
Authors: Martínez-Casanova Elena , Molero-Jurado María del Mar , Pérez-Fuentes María del Carmen
Published: May 2024

Adolescence is recognised as a notoriously vulnerable period in the human life cycle. Influenced by a complex interplay of biological, psychological and social factors, adolescents show a marked propensity to engage in risk behaviours. A systematic review was conducted of studies published in the Web of Science, PsycInfo and MEDLINE databases over the last decade, with the aim of collecting studies on the relationship between self-esteem and risk behaviour in individuals aged 12–18 years. The aim was to confirm the role of high self-esteem as a consistent protective factor against risk behaviour. The results show that self-esteem is negatively related to risk behaviour. Our results also reflect the need for further research on how sociodemographic factors, among others, affect the relationship between self-esteem and risk behaviours. This review highlights the relevance of implementing specific educational interventions to strengthen self-esteem in adolescents, with the aim of preventing various risk behaviours that may emerge during adolescence and persist throughout life if not addressed early.
Tools and Techniques for Improving Maturity Partnering in Indonesian Construction Projects
Authors: Thohirin Antho , Wibowo Mochamad Agung , Mohamad Dadang , Sari Endah Murtiana , Tamin Rizal Zainuddin , Sulistio Hendrick
Published: May 2024

The construction industry is naturally complex and constantly changing, with various factors impacting project results. Among the different methods developed to navigate this complexity, partnering is believed to increase project value and performance. Therefore, this research aimed at analyzing and formulating elements as well as indicators at each phase of a partnership-based project life cycle, serving as tools and techniques for measuring the depth of partnering in construction projects. The methodology used included both qualitative and quantitative methods (mixed method). In the qualitative method, the literature from relevant journals, books, and previous research was reviewed. This process was followed by an expert assessment through a Focus Group Discussion (FGD) to define elements and indicators for measuring the depth of partnering in construction projects. Meanwhile, the quantitative method comprised analyzing secondary project data to compare projects with in-depth partnering in order to deliver better value. The result of this research was the development of Key Performance Indicators (KPIs) to measure maturity partnering in partnership-based projects. Typically, the tools were adjusted to different phases of the project life cycle, starting from project initiation, comprising all stakeholders. Consequently, the outcome of this research could be used by organizations in the construction industry to develop partnering in partnership projects in Indonesia.
Residents’ and Architects’ Perceptions of Apartments’ Spatial Characteristics—Identifying Differences in Opinion on a Case Study of Osijek, Croatia
Authors: Brkanić Mihić Ivana , Koški Danijela
Published: May 2024

People spend up to 45% of their time in their living space, which has a major impact on their physical and mental health, behaviour, happiness and overall life satisfaction. In these times of rapid change and new, modern demands on living, it is necessary to understand the needs of residents and current design trends in order to incorporate both into the design of new living spaces. The aim of this study is to use the views of residents and architects collected through surveys to rank apartments and identify differences in the definition of what a high-quality apartment would be based on their spatial characteristics. The previously developed Housing Quality Assessment Model was used to assess the 126 most represented apartment layouts in the city of Osijek, Croatia, built since 1930. Apartment layouts were further divided according to the time of their construction, location, and size for comparison purposes. The research shows that residents rated apartments with higher ratings than architects in all categories and that residents and architects gave different ratings on certain characteristics of the apartment, e.g., the existence of additional storage space, the existence of a bathroom window, the size and orientation of living rooms, the type of spatial organisation, etc.
Children’s Hospital Environment Design Based on AHP/QFD and Other Theoretical Models
Authors: Zheng Haohua , Liu Lingying , Zhang Qi , Wang Yihan , Wei Yangyang
Published: May 2024

Spatial environmental factors can effectively alleviate children’s fear of the medical environment when they seek medical treatment. This study focuses on the special environmental space of a children’s hospital, thoroughly considering the emotional needs of and the therapeutic effects on children as a unique group during medical treatment. By analyzing the existing design of children’s hospital environments, this research actively explores more suitable environmental design solutions for children’s healthcare settings. This study summarizes the user demand factors of children’s hospital environmental space design through field research and analysis interviews and calculates the weight indicators of user demand through AHP hierarchical analysis. On this basis, based on the QFD theoretical model, user needs are transformed into technical needs, and a house of quality is drawn to judge the conflicting needs through the positive and negative correlations between the factors. Finally, the forty invention principles of the TRIZ innovation theory are used to propose a solution to the environmental space program of children’s hospitals to obtain the optimal solution to the environmental space design effect. This study shows that incorporating theoretical models of AHP, QFD, and TRIZ into the environmental space design of children’s hospitals can improve and optimize the environmental space of children’s hospitals, and the example of a children’s hospital can be designed to meet children’s emotional needs according to this model. A series of interesting innovative practices, such as personalized digital information diagnosis and treatment, interesting visual guidance, and the implicit healing effect of color, can be realized. The aim is to create a modern, child-friendly medical environment that not only meets medical functional requirements but also effectively alleviates the stress of pediatric patients during diagnosis and treatment. This study preliminarily verifies the scientificity and rationality of the entire design process and provides a reference for the design practices of children’s hospital environments.
Internal Responsiveness of EQ-5D-5L and EORTC QLQ-C30 in Dutch Breast Cancer Patients during the First Year Post-Surgery: A Longitudinal Cohort Study
Authors: Vrancken Peeters Noëlle J. M. C. , van Til Janine A. , Huberts Anouk S. , Siesling Sabine , Husson Olga , Koppert Linetta B.
Published: May 2024

The EuroQoL 5-Dimension 5-Level questionnaire (EQ-5D-5L) and the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 (EORTC QLQ-C30) are commonly used Patient-Reported Outcome Measures (PROMs) for breast cancer. This study assesses and compares the internal responsiveness of the EQ-5D-5L and EORTC QLQ-C30 in Dutch breast cancer patients during the first year post-surgery. Women diagnosed with breast cancer who completed the EQ-5D-5L and EORTC QLQ-C30 pre-operatively (T0), 6 months (T6), and 12 months post-surgery (T12) were included. Mean differences of the EQ-5D-5L and EORTC QLQ-C30 between baseline and 6 months (delta 1) and between baseline and 12 months post-surgery (delta 2) were calculated and compared against the respective minimal clinically important differences (MCIDs) of 0.08 and 5. Internal responsiveness was assessed using effect sizes (ES) and standardized response means (SRM) for both deltas. In total, 333 breast cancer patients were included. Delta 1 and delta 2 for the EQ-5D-5L index and most scales of the EORTC QLQ-C30 were below the MCID. The internal responsiveness for both PROMs was small (ES and SRM < 0.5), with greater internal responsiveness for delta 1 compared to delta 2. The EQ-5D-5L index showed greater internal responsiveness than the EORTC QLQ-C30 Global Quality of Life scale and summary score. These findings are valuable for the interpretation of both PROMs in Dutch breast cancer research and clinical care.
Radiotherapy for Recurrent Medulloblastoma in Children and Adolescents: Survival after Re-Irradiation and First-Time Irradiation
Authors: Adolph Jonas E. , Fleischhack Gudrun , Tschirner Sebastian , Rink Lydia , Dittes Christine , Mikasch Ruth , Dammann Philipp , Mynarek Martin , Obrecht-Sturm Denise , Rutkowski Stefan , Bison Brigitte , Warmuth-Metz Monika , Pietsch Torsten , Pfister Stefan M. , Pajtler Kristian W. , Milde Till , Kortmann Rolf-Dieter , Dietzsch Stefan , Timmermann Beate , Tippelt Stephan
Published: May 2024

Background: Radiotherapy (RT) involving craniospinal irradiation (CSI) is important in the initial treatment of medulloblastoma. At recurrence, the re-irradiation options are limited and associated with severe side-effects. Methods: For pre-irradiated patients, patients with re-irradiation (RT2) were matched by sex, histology, time to recurrence, disease status and treatment at recurrence to patients without RT2. Results: A total of 42 pre-irradiated patients with RT2 were matched to 42 pre-irradiated controls without RT2. RT2 improved the median PFS [21.0 (CI: 15.7–28.7) vs. 12.0 (CI: 8.1–21.0) months] and OS [31.5 (CI: 27.6–64.8) vs. 20.0 (CI: 14.0–36.7) months]. Concerning long-term survival after ten years, RT2 only lead to small improvements in OS [8% (CI: 1.4–45.3) vs. 0%]. RT2 improved survival most without (re)-resection [PFS: 17.5 (CI: 9.7–41.5) vs. 8.0 (CI: 6.6–12.2)/OS: 31.5 (CI: 27.6–NA) vs. 13.3 (CI: 8.1–20.1) months]. In the RT-naïve patients, CSI at recurrence improved their median PFS [25.0 (CI: 16.8–60.6) vs. 6.6 (CI: 1.5–NA) months] and OS [40.2 (CI: 18.7–NA) vs. 12.4 (CI: 4.4–NA) months]. Conclusions: RT2 could improve the median survival in a matched cohort but offered little benefit regarding long-term survival. In RT-naïve patients, CSI greatly improved their median and long-term survival.
Helicobacter pylori Infection in Patients with Gastric Cancer: A 2024 Update
Authors: Burz Claudia , Pop Vlad , Silaghi Ciprian , Lupan Iulia , Samasca Gabriel
Published: May 2024

Numerous studies have been performed on Helicobacter pylori infection because of the high death rate linked to this illness and gastric cancer. An update on the key developments in recent years in the investigation of Helicobacter pylori and gastric cancer is the goal of this review. Using the search term “Helicobacter pylori, gastric cancer”, the PubMed database was searched. Only papers published in 2024 fulfilled the inclusion criteria. Because case report papers were not part of our investigation, they satisfied the exclusion criteria. Most of the research on the variable genes of Helicobacter pylori is guided by genetics to determine potential treatments. Studies on clinical treatments for the eradication of H. pylori with promising therapeutic options are needed. We found the fewest studies related to the immunopathology of H. pylori infection, which is still unknown. In conclusion, priority should be given to this kind of research.
GAS-Luc2 Reporter Cell Lines for Immune Checkpoint Drug Screening in Solid Tumors
Authors: Chang Hyeyoun , Foulke John G. , Chen Luping , Tian Fang , Gu Zhizhan
Published: May 2024

Recent studies highlight the integral role of the interferon gamma receptor (IFNγR) pathway in T cell–mediated cytotoxicity against solid but not liquid tumors. IFNγ not only directly facilitates tumor cell death by T cells but also indirectly promotes cytotoxicity via myeloid phagocytosis in the tumor microenvironment. Meanwhile, full human ex vivo immune checkpoint drug screening remains challenging. We hypothesized that an engineered gamma interferon activation site response element luciferase reporter (GAS-Luc2) can be utilized for immune checkpoint drug screening in diverse ex vivo T cell–solid tumor cell co-culture systems. We comprehensively profiled cell surface proteins in ATCC’s extensive collection of human tumor and immune cell lines, identifying those with endogenously high expression of established and novel immune checkpoint molecules and binding ligands. We then engineered three GAS-Luc2 reporter tumor cell lines expressing immune checkpoints PD-L1, CD155, or B7-H3/CD276. Luciferase expression was suppressed upon relevant immune checkpoint–ligand engagement. In the presence of an immune checkpoint inhibitor, T cells released IFNγ, activating the JAK-STAT pathway in GAS-Luc2 cells, and generating a quantifiable bioluminescent signal for inhibitor evaluation. These reporter lines also detected paracrine IFNγ signaling for immune checkpoint-targeted ADCC drug screening. Further development into an artificial antigen-presenting cell line (aAPC) significantly enhanced T cell signaling for superior performance in these ex vivo immune checkpoint drug screening platforms.
Construction of a Novel Ternary GQDs/g-C3N4/ZIF-67 Photocatalyst for Enhanced Photocatalytic Carbon Dioxide Reduction
Authors: Zhao Zhiyuan , Wang Jingjing , Xu Congnian , Du Zhao , Yu Rongrong , Zhao Yongqi , Han Jiayi , Zuo Jingtao , Guo Zhonglu , Tang Chengchun , Fang Yi
Published: May 2024

In this study, graphene quantum dots (GQDs) have been incorporated into the g-C3N4/ZIF-67 heterojunction system as a photosensitizer to enhance photocatalytic conversion of CO2-to-CO. The GQDs are deposited onto the surface of g-C3N4/ZIF-67 using a simple water bath procedure. As expected, GQDs/g-C3N4/ZIF-67 presents outstanding performance in CO2 photoreduction. Among the GQDs/g-C3N4/ZIF-67 ternary photocatalysts, 7 GQDs-CN/ZIF-67 exhibits the best photocatalytic CO2 reduction ability with a CO yield of 51.71 μmol g−1, which is 5.05 and 1.87 times more than pristine g-C3N4 (10.24 μmol g−1) and g-C3N4/ZIF-67 (27.65 μmol g−1), respectively. This result shows that upon combination of GQDs with ZIF-67/g-C3N4, GQDs can be used as photosensitizers to improve the optical absorption capacity of the photocatalyst. Furthermore, GQDs serve as electron channels, facilitating the transport of photo-induced electrons from ZIF-67 to g-C3N4, which promotes photogenerated carrier separation efficiency. This study innovatively adds GQDs to the heterojunction and applies the prepared ternary composite to the CO2 photoreduction, which inspires a novel direction for the design of non-noble metal photocatalysts.
Na2SO3-Promoted Heck Coupling and Homo-Coupling of Arylhydrazines at Room Temperature
Authors: Du Jianxiong , Wang Wanhe , Liu Jin-Biao , Luo Nianhua
Published: May 2024

A novel protocol facilitated by Na2SO3 that enhances the efficiency of palladium-catalyzed Heck coupling and the homo-coupling reactions of arylhydrazines. This innovative method enables the effective construction of a diverse array of cinnamate derivatives and biphenyl compounds. Notably, these transformative reactions proceed smoothly at room temperature, leveraging the activation of C-N bonds. This technique not only streamlines the synthesis process but also expands our understanding and expertise in the realm of coupling reactions.
Updates on Disease Mechanisms and Therapeutics for Amyotrophic Lateral Sclerosis
Authors: Nguyen Lien
Published: May 2024

Amyotrophic lateral sclerosis (ALS), or Lou Gehrig’s disease, is a motor neuron disease. In ALS, upper and lower motor neurons in the brain and spinal cord progressively degenerate during the course of the disease, leading to the loss of the voluntary movement of the arms and legs. Since its first description in 1869 by a French neurologist Jean-Martin Charcot, the scientific discoveries on ALS have increased our understanding of ALS genetics, pathology and mechanisms and provided novel therapeutic strategies. The goal of this review article is to provide a comprehensive summary of the recent findings on ALS mechanisms and related therapeutic strategies to the scientific audience. Several highlighted ALS research topics discussed in this article include the 2023 FDA approved drug for SOD1 ALS, the updated C9orf72 GGGGCC repeat-expansion-related mechanisms and therapeutic targets, TDP-43-mediated cryptic splicing and disease markers and diagnostic and therapeutic options offered by these recent discoveries.
A Focus on the Pathophysiology of Adrenomedullin Expression: Endothelitis and Organ Damage in Severe Viral and Bacterial Infections
Authors: Spoto Silvia , Basili Stefania , Cangemi Roberto , Yuste José Ramón , Lucena Felipe , Romiti Giulio Francesco , Raparelli Valeria , Argemi Josepmaria , D’Avanzo Giorgio , Locorriere Luciana , Masini Francesco , Calarco Rodolfo , Testorio Giulia , Spiezia Serenella , Ciccozzi Massimo , Angeletti Silvia
Published: May 2024

Adrenomedullin (ADM) is a peptide hormone produced primarily in the adrenal glands, playing a crucial role in various physiological processes. As well as improving vascular integrity and decreasing vascular permeability, ADM acts as a vasodilator, positive inotrope, diuretic, natriuretic and bronchodilator, antagonizing angiotensin II by inhibiting aldosterone secretion. ADM also has antihypertrophic, anti-apoptotic, antifibrotic, antioxidant, angiogenic and immunoregulatory effects and antimicrobial properties. ADM expression is upregulated by hypoxia, inflammation-inducing cytokines, viral or bacterial substances, strength of shear stress, and leakage of blood vessels. These pathological conditions are established during systemic inflammation that can result from infections, surgery, trauma/accidents or burns. The ability to rapidly identify infections and the prognostic, predictive power makes it a valuable tool in severe viral and bacterial infections burdened by high incidence and mortality. This review sheds light on the pathophysiological processes that in severe viral or bacterial infections cause endothelitis up to the development of organ damage, the resulting increase in ADM levels dosed through its more stable peptide mid-regional proadrenomedullin (MR-proADM), the most significant studies that attest to its diagnostic and prognostic accuracy in highlighting the severity of viral or bacterial infections and appropriate therapeutic insights.
Cell-Based Therapy for Fibrosing Interstitial Lung Diseases, Current Status, and Potential Applications of iPSC-Derived Cells
Authors: Nakamura Yusuke , Niho Seiji , Shimizu Yasuo
Published: May 2024

Fibrosing interstitial lung diseases (FILDs), e.g., due to idiopathic pulmonary fibrosis (IPF), are chronic progressive diseases with a poor prognosis. The management of these diseases is challenging and focuses mainly on the suppression of progression with anti-fibrotic drugs. Therefore, novel FILD treatments are needed. In recent years, cell-based therapy with various stem cells has been investigated for FILD, and the use of mesenchymal stem cells (MSCs) has been widely reported and clinical studies are also ongoing. Induced pluripotent stem cells (iPSCs) have also been reported to have an anti-fibrotic effect in FILD; however, these have not been as well studied as MSCs in terms of the mechanisms and side effects. While MSCs show a potent anti-fibrotic effect, the possibility of quality differences between donors and a stable supply in the case of donor shortage or reduced proliferative capacity after cell passaging needs to be considered. The application of iPSC-derived cells has the potential to overcome these problems and may lead to consistent quality of the cell product and stable product supply. This review provides an overview of iPSCs and FILD, followed by the current status of cell-based therapy for FILD, and then discusses the possibilities and perspectives of FILD therapy with iPSC-derived cells.
Associations between Motor Competence, Physical Activity and Sedentary Behaviour among Early School-Aged Children in the SELMA Cohort Study
Authors: Delvert Johanna , Wadensjö Heléne V. , Bornehag Carl-Gustaf , Wikström Sverre
Published: May 2024

Low motor competence (MC) has been associated with lower physical activity (PA) and long-term health risks in children. Less is known about sex-specific patterns and associations during early school age. The aim of this study was to explore how motor difficulties are associated with PA levels, screen time, and organised sports participation (OSP). Data from 479 children, seven years of age, participating in the Swedish Environmental, Longitudinal, Mother and child, Asthma, and allergy (SELMA) pregnancy cohort study were used. MC and activity-related outcomes were assessed with questionnaires answered by parents. Associations between MC and outcomes were evaluated using logistic regression models adjusted for sex, overweight, and parental education level. Sex differences were investigated with interaction analyses and in stratified models. Children with motor difficulties had the same level of PA as their peers, but more screen time and lower OSP. Compared with children with normal MC, boys with motor difficulties had lower rates of OSP, but girls did not. This indicates that the identification and compensatory support for motor difficulties for boys at an early age, as well as the development of inclusive leisure time activities, are of importance to facilitate health-promoting activities on equal terms.
Mediator Role of Dissociative Experiences in the Effect of Childhood Traumas on Emotion Regulation Difficulty and Parental Child-Containing Function
Authors: Yöyen Elif , Bal Fatih , Barış Tülay Güneri , Arslan Meryem Selva , Çokluk Gülşen Filazoğlu
Published: May 2024

The aim of this study is to examine the mediating role of dissociation in emotional regulation and parental child-containing function skills of mothers exposed to childhood trauma. The research was conducted with 400 mothers between the ages of 20–60 who had childhood trauma and currently have children between the ages of 0–18. The relational screening model, one of the general screening models, was used in the research. The sample of the research was selected using the convenient sampling method and the simple random method. Research data were collected with the Sociodemographic Information Form, Childhood Trauma Scale (CTS), Parental Child-Containing Function Scale (PCCFS), Emotion Regulation Difficulty Scale (ERDS), and Dissociative Experiences Scale (DES). According to the results obtained in the study, physical abuse (β = 0.197; 95% CI [0.124; 0.268]), physical neglect (β = 0.232; 95% CI [0.161; 0.306]), emotional abuse (β = 0.238; 95% CI [0.169; 0.309]), emotional neglect (β = 0.210; 95% CI [0.150; 0.275]), and sexual abuse (β = 0.139; 95% CI [0.058; 0.220]) were found to have a significant indirect effect on emotion regulation difficulties through dissociative experiences. In addition, physical abuse (β = 0.122; 95% CI [0.071; 0.181]), physical neglect (β = 0.151; 95% CI [0.084; 0.228]), emotional abuse (β = 0.158; 95% CI [0.086; 0.238]), emotional neglect (β = 0.159; 95% CI [0.093; 0.235]), and sexual abuse (β = 0.086; 95% CI [0.039; 0.150] was found to have a significant indirect effect on parental child-containing function skills through dissociative experiences.
Potential Application of MicroRNAs and Some Other Molecular Biomarkers in Alzheimer’s Disease
Authors: Paprzycka Olga , Wieczorek Jan , Nowak Ilona , Madej Marcel , Strzalka-Mrozik Barbara
Published: May 2024

Alzheimer’s disease (AD) is the world’s most common neurodegenerative disease, expected to affect up to one-third of the elderly population in the near future. Among the major challenges in combating AD are the inability to reverse the damage caused by the disease, expensive diagnostic tools, and the lack of specific markers for the early detection of AD. This paper highlights promising research directions for molecular markers in AD diagnosis, including the diagnostic potential of microRNAs. The latest molecular methods for diagnosing AD are discussed, with particular emphasis on diagnostic techniques prior to the appearance of full AD symptoms and markers detectable in human body fluids. A collection of recent studies demonstrates the promising potential of molecular methods in AD diagnosis, using miRNAs as biomarkers. Up- or downregulation in neurodegenerative diseases may not only provide a new diagnostic tool but also serve as a marker for differentiating neurodegenerative diseases. However, further research in this direction is needed.
Efficacy of Non-Surgical Periodontal Therapy with Adjunctive Methylene Blue and Toluidine Blue O Mediated Photodynamic in Treatment of Periodontitis: A Randomized Clinical Trial
Authors: Najm Kashan Kamal , Gul Sarhang Sarwat , Abdulkareem Ali Abbas
Published: May 2024

Background: This study aimed to examine the efficacy of methylene blue (MB) and toluidine blue O (TBO) photodynamic therapy (PDT) as adjuncts to root surface debridement (RSD). Methods: This split-mouth, randomized, controlled clinical trial included eighteen patients, and a total of 332 sites (control = 102, MB = 124 and TBO = 106) were examined. Two sessions of PDT were completed at baseline and two weeks after RSD. Clinical parameters of bleeding on probing (BOP), plaque index (PI), probing pocket depth (PPD), and clinical attachment level (CAL) were measured pre- and post-treatment. Results: PPD and BOP reductions in sites treated by RSD with adjunctive photosensitizers (MB and TBO) were significantly higher than in control sites. RSD with MB showed higher efficacy in improving moderately deep pockets (OR 3.350), while adjunctive TBO showed better results in treating deeper pockets (OR 4.643). Conclusions: Results suggested that adjunctive use of MB and TBO to RSD could significantly improve periodontal pocket closure and reduce signs of inflammation. In addition, TBO seems to be more efficient in treating deep periodontal pockets than MB, which is more effective in resolving shallower pockets.
Preparation of Toddalia asiatica (L.) Lam. Extract Microcapsules and Their Effect on Optical, Mechanical and Antibacterial Performance of Waterborne Topcoat Paint Films
Authors: Wang Ying , Yan Xiaoxing
Published: May 2024

The antibacterial microcapsules were prepared by encapsulating Toddalia asiatica (L.) Lam. extracts with urea–formaldehyde resin. The orthogonal test was designed to investigate the effects of the mass ratio of core and wall materials (Wcore:Wwall), emulsifier concentration, reaction temperature and reaction time on the yield rate and coverage rate of microcapsules, and to obtain the best preparation technology for microcapsules. The single-factor results indicated that the maximum influence factor was the Wcore:Wwall of the microcapsules; the larger the Wcore:Wwall, the easier the microcapsules were to agglomerate; and when the Wcore:Wwall was 0.8:1, the coverage rate reached the maximum value of 11.0%. The waterborne topcoat paint film was prepared by adding the microcapsules in the same content. The yield rate, coverage rate, and microscopic morphology of Toddalia asiatica (L.) Lam. extract microcapsules were analyzed, as well as the effects of microcapsules on the microscopic morphology, optical properties, cold liquid resistance, mechanical properties and antibacterial properties of a waterborne topcoat paint film. Combining the optical properties, cold liquid resistance, physical properties, and antibacterial properties of the waterborne topcoat paint film, the comprehensive performance of the waterborne topcoat paint film with the Wcore:Wwall of 0.8:1 was superior. The gloss was 8.07 GU, color difference ΔE was 9.21, visible light transmittance was 82.90%, resistance to citric acid, ethanol and detergent were grade 1, 2 and 2, respectively, elongation at break was 15.68%, and roughness was 3.407 µm. The antibacterial activity against Escherichia coli and Staphylococcus aureus were 42.82% and 46.05%, respectively. In this study, a waterborne topcoat paint film with a microcapsule-coated plant-derived antibacterial agent as the core was prepared, expanding the application prospect of plant-derived antibacterial microcapsules.
Corrosion Resistance of Atomically Thin Graphene Coatings on Single Crystal Copper
Authors: Hasan Md Mahmudul , Devadig Ramesh , Sigdel Pawan , Lipatov Alexey , Avci Recep , Jasthi Bharat K. , Gadhamshetty Venkataramana
Published: May 2024

Designing minimally invasive, defect-free coatings based on conformal graphene layers to shield metals from both abiotic and biotic forms of corrosion is a persistent challenge. Single-layer graphene (SLG) grown on polycrystalline copper (PC-Cu) surfaces often have inherent defects, particularly at Cu grain boundaries, which weaken their barrier properties and worsen corrosion through grain-dependent mechanisms. Here, we report that an SLG grown via chemical vapor deposition (CVD) on Cu (111) single crystal serves as a high-performance coating to lower corrosion by nearly 4–6 times (lower than bare Cu (111)) in abiotic (sulfuric acid) and microbiologically influenced corrosion (MIC) environments. For example, the charge transfer resistance for SLG/Cu (111) (3.95 kΩ cm2) was 2.5-fold higher than for bare Cu (111) (1.71 kΩ cm2). Tafel analysis corroborated a reduced corrosion current (42 ± 3 µA cm−2) for SLG/Cu (111) compared to bare Cu (111) (115 ± 7 µA cm−2). These findings are consistent with the results based on biofilm measurements. The SLG/Cu (111) reduced biofilm formation by 3-fold compared to bare Cu (111), increasing corrosion resistance, and effectively mitigating pitting corrosion. The average depths of the pits (3.4 ± 0.6 µm) for SLG/Cu (111) were notably shallower than those of bare Cu (111) (6.5 ± 1.2 µm). Surface analysis of the corrosion products corroborated these findings, with copper sulfide identified as a major component across both surfaces. The absence of grain boundaries in Cu (111) resulted in high-quality SLG manifesting higher barrier properties compared to SLG on PC-Cu. Our findings show promise for using the presented strategy for developing durable graphene coatings against diverse forms of corrosion.
New Mitigation Strategies for Cement Prehydration
Authors: Ozersky Alexander , Khomyakov Alexander , Zhao Pengfei , Herzog Bromerchenkel Lucas , Chernoloz Oleksiy , Peterson Karl
Published: May 2024

Portland cement has a limited shelf life because of the prehydration that can occur during storage. One approach to mitigating strength losses observed for concrete is to pretreat cement with a protective coating to slow the advance of prehydration. This study compared cement pretreatments with alkyl ketene dimer (AKD) wax and a combination of AKD + paraffin wax to a more traditional pretreatment approach using oleic acid. After exposing the treated cements to elevated temperature and humidity conditions, paste and mortar calorimetry tests showed improved resistance to prehydration reactions. The cements aged up to 12 weeks under the accelerated regime showed strength improvement for the mortars made with AKD and AKD + paraffin-treated cements relative to the mortars made with oleic acid-treated cement and mortars made with untreated cement. The wax can be added during clinker milling and additionally functions as a grinding aid.
Synthesis and Mechanism Study of Carbon Nanowires, Carbon Nanotubes, and Carbon Pompons on Single-Crystal Diamonds
Authors: Wu Shuai , Wang Qiang , Guo Kesheng , Liu Lei , Bai Jie , Yang Zhenhuai , Li Xin , Liu Hong
Published: May 2024

Carbon nanomaterials are in high demand owing to their exceptional physical and chemical properties. This study employed a mixture of CH4, H2, and N2 to create carbon nanostructures on a single-crystal diamond using microwave plasma chemical vapor deposition (MPCVD) under high-power conditions. By controlling the substrate surface and nitrogen flow rate, carbon nanowires, carbon nanotubes, and carbon pompons could be selectively deposited. The results obtained from OES, SEM, TEM, and Raman spectroscopy revealed that the nitrogen flow rate and substrate surface conditions were crucial for the growth of carbon nanostructures. The changes in the plasma shape enhanced the etching effect, promoting the growth of carbon pompons. The CN and C2 groups play vital catalytic roles in the formation of carbon nanotubes and nanowires, guiding the precipitation and composite growth of carbon atoms at the interface between the Mo metal catalysts and diamond. This study demonstrated that heterostructures of diamond–carbon nanomaterials could be produced under high-power conditions, offering a new approach to integrating diamond and carbon nanomaterials.
Enhanced Supercapacitor Performance by Harnessing Carbon Nanoparticles and Colloidal SnO2 Quantum Dots
Authors: Salunkhe Tejaswi Tanaji , Bathula Babu , Kim Il Tae , Thirumal Vediyappan , Yoo Kisoo
Published: May 2024

The creation of effective supercapacitor materials is still a priority in the quest to improve energy storage technology. Herein, we present a novel nanocomposite composed of carbon nanoparticles (CNPs) and colloidal SnO2 quantum dots (c-SQDs) or colloidal SnO2 ultrasmall nanoparticles, synthesized through a facile sonochemical-assisted hydrothermal approach. The XRD and XPS analyses confirmed the successful synthesis and composition of the CNP/c-SQD nanocomposite. Morphology studies revealed a well-dispersed morphology with intimate interfacial interactions between the CNPs and c-SQDs. Specifically, the nanocomposite exhibited a high specific capacitance of 569 F/g at a current density of 1 A/g, surpassing conventional carbon-based supercapacitors. Furthermore, the nanocomposite displayed excellent stability with 99% capacity retention after 5000 cycles, indicative of its superior cyclability. These results underscore the potential of the CNP/c-SQD nanocomposite as a promising electrode material for high-performance supercapacitor applications, offering enhanced charge storage capacity, stability, and cyclability. This study contributes to the advancement of energy storage technologies, paving the way for the development of efficient and sustainable electrochemical energy storage devices.
Solid Forms and β-Cyclodextrin Complexation of Oxymetholone and Crystal Structure of Metribolone
Authors: Borodi Gheorghe , Miclaus Maria Olimpia , Muresan-Pop Marieta , Turza Alexandru
Published: May 2024

Oxymetholone [C21H32O3] and metribolone [C19H24O2] are synthetic anabolic-androgenic agents which are included in the steroid class. Their ability to form new solid forms and their possibility to be included in host-guest β-cyclodextrin complexes was explored. The recrystallization of the compounds in a wide variety of solvents was accomplished. Two oxymetholone polymorphs and one oxymetholone acetic acid solvate were obtained:, while metribolone is reported only in the starting form. Their crystal structures were elucidated using single-crystal X-ray diffraction and the energies of intermolecular interactions were analyzed. Moreover, oxymetholone also showed the ability to be complexed in a new form of oxymetholone-β-cyclodextrin complex. The materials were also investigated by powder X-ray diffraction, DSC/DTA/TGA analysis, and FT-IR spectroscopy.
Prediction of Seropositivity in Suspected Autoimmune Encephalitis by Use of Radiomics: A Radiological Proof-of-Concept Study
Authors: Stake Jacob , Spiekers Christine , Akkurt Burak Han , Heindel Walter , Brix Tobias , Mannil Manoj , Musigmann Manfred
Published: May 2024

In this study, we sought to evaluate the capabilities of radiomics and machine learning in predicting seropositivity in patients with suspected autoimmune encephalitis (AE) from MR images obtained at symptom onset. In 83 patients diagnosed with AE between 2011 and 2022, manual bilateral segmentation of the amygdala was performed on pre-contrast T2 images using 3D Slicer open-source software. Our sample of 83 patients contained 43 seropositive and 40 seronegative AE cases. Images were obtained at our tertiary care center and at various secondary care centers in North Rhine-Westphalia, Germany. The sample was randomly split into training data and independent test data. A total of 107 radiomic features were extracted from bilateral regions of interest (ROIs). Automated machine learning (AutoML) was used to identify the most promising machine learning algorithms. Feature selection was performed using recursive feature elimination (RFE) and based on the determination of the most important features. Selected features were used to train various machine learning algorithms on 100 different data partitions. Performance was subsequently evaluated on independent test data. Our radiomics approach was able to predict the presence of autoantibodies in the independent test samples with a mean AUC of 0.90, a mean accuracy of 0.83, a mean sensitivity of 0.84 and a mean specificity of 0.82, with Lasso regression models yielding the most promising results. These results indicate that radiomics-based machine learning could be a promising tool in predicting the presence of autoantibodies in suspected AE patients. Given the implications of seropositivity for definitive diagnosis of suspected AE cases, this may expedite diagnostic workup even before results from specialized laboratory testing can be obtained. Furthermore, in conjunction with recent publications, our results indicate that characterization of AE subtypes by use of radiomics may become possible in the future, potentially allowing physicians to tailor treatment in the spirit of personalized medicine even before laboratory workup is completed.
Evaluating Diagnostic Clarity: The Comparative Efficacy of BlueStain in Serous Effusion Cytology under the International System for Reporting Serous Fluid Cytopathology Reporting Framework
Authors: Alves Paula Melo , Azevedo Maria Teresa , Ferreira Fernando , Tastekin Ebru , Canberk Sule , Schmitt Fernando C.
Published: May 2024

Serous effusion cytology is a pivotal diagnostic and staging tool in clinical pathology, valued for its simplicity and cost-effectiveness. Staining techniques such as Giemsa and Papanicolaou are foundational, yet the search for rapid and efficient alternatives continues. Our study assesses the efficacy of an in-house-developed BlueStain, a toluidine blue variant, within the International System for Reporting Serous Fluid Cytopathology (TIS), aiming to optimize diagnostic clarity and resource use. Materials and Methods: This section provides details on the cohort of 237 patients with serous effusions, the ethical approval process, sample collection, and staining procedures with BlueStain, Papanicolaou, and Giemsa. It also describes the microscopic evaluation criteria, scoring system, and statistical methods used to compare the stains. Results: BlueStain demonstrated notable performance, particularly in identifying malignant cells, presenting a competitive alternative to the Papanicolaou stain, which, despite higher quality indices in other categories, requires more resources and time. The study revealed that BlueStain might offer a valuable balance between quality and efficiency, especially in cases where rapid diagnostic turnaround is essential. Conclusions: Our findings suggest that BlueStain is a viable staining method in the context of serous effusions, capable of providing detailed cytomorphological analysis. While traditional stains hold their place for their established diagnostic clarity, BlueStain offers a rapid and resource-optimized alternative. The absence of definitive diagnostic criteria in the atypical category and the inherent sample heterogeneity underscores the necessity for adaptable staining methods like BlueStain. The study highlights the potential trade-offs between detail and practicality in staining techniques, advocating for further research into innovative methods that do not compromise diagnostic precision for cost and time efficiency.