bluuebunny/crossref_metadata_2025 huggingface dataset:
Market approach to provision of housing to low-income households in urban Malawi: a panacea or further dispossession?
Authors: Zuka Sane
Published: March 2024

Purpose

The purpose of this study is to examine the effects of market-based approach to provision of housing to low-income households in urban Malawi.

Design/methodology/approach

This study was conducted in Blantyre, Malawi, between 2019 and 2022 and used both quantitative (household survey) and qualitative (in-depth interviews and document study) methods of data collection. Interviews were conducted with key players and investors in the housing sector. Household survey data were analyzed through descriptive statistics, which allowed the generation of descriptive housing valuables, whereas qualitative data were analyzed through content analysis.

Findings

This paper demonstrates that, rather than ameliorating the housing problems facing low-income households, the market approach to provision of housing in Malawi has worsened the housing situation in the country. This is so because the market approach to the provision of housing in Malawi is not only enforcing the logic of capitalistic accumulation in the housing sector but also supporting mechanisms of exclusion based on economic stratification within the community.

Research limitations/implications

Completeness of data over time as there is no market data bank available in the country.

Practical implications

The findings from this study suggest that some degree of state intervention in addressing the housing problem in Malawi is required.

Social implications

The study findings suggest that a market approach to the provision of housing can increase social inequality as low-income households face challenges in accessing housing.

Originality/value

There is a paucity of research on the effects of the market approach on the provision of affordable housing to low-income households in Malawi. This paper assesses this important policy gap and provides significant policy directions.
Managing quality assurance at community colleges in Ontario, Canada: experiences and perspectives of front-line quality managers
Authors: Jarrell Laura , Kirby Dale
Published: March 2024

Purpose

This paper aims to examine the roles of quality managers at community colleges, their experiences balancing accountability and improvement and their insights into the future of quality assurance.

Design/methodology/approach

This phenomenological, qualitative study used semi-structured interviews with eight community college quality managers to investigate their roles, experiences and perspectives. A reflexive thematic approach was used to analyze the interview data.

Findings

Four themes were identified from participant responses: quality managers frame and enable program quality, quality managers drive program change, quality managers cultivate a culture of quality and quality managers seek system change. The findings illustrate the roles played by quality managers as they work to improve college education at program, institution and system-wide levels.

Research limitations/implications

The decision of participants to accept the recruitment invitation might reflect particular attitudes, perspectives or experiences.

Practical implications

Quality assurance has emerged as a key mechanism for ensuring postsecondary programs are current, relevant and meeting the evolving needs of students and employers. This study advances the understanding of how quality assurance processes play out at the operational level and explores the experiences of quality managers as they navigate various quality tensions.

Originality/value

Quality managers play key roles in leading, evaluating and influencing quality assurance processes in postsecondary education yet they are underrepresented in the literature. The findings of this study shed new light on the aspirational and influential roles they play in advancing quality assurance.
Deciding where to put them: Sensitivity tests and independent evaluation are critical when using species distribution models to inform conservation translocations
Authors: Finn Kaegan J. , Bergman Jayna C. , Lee‐Yaw Julie A.
Published: March 2024

Conservation translocations are an important tool for combating species declines and population losses. Species distribution models (SDMs) can facilitate the selection of suitable release sites for translocation programs. However, these models can be sensitive to several modelling decisions.

In this study, we explore the impacts of three key modelling decisions on Maxent models developed to inform reintroductions of the long‐toed salamander (Ambystoma macrodactylum) in southwestern Alberta. We specifically test the sensitivity of model predictions to (1) the type of environmental variables used to generate models, (2) whether the background points used to calibrate the models reflects the potential bias in the input locality records and (3) the choice of geographic study extent. We use independent presence‐absence data from an extensive field survey to test the accuracy of models based on different decisions.

Both model predictions and performance were sensitive to these modelling decisions. Models developed using local study extents were more accurate than those based on range‐wide extents. Both study extent and type of background points impacted model predictions and performance more than the set of environmental variables included in the models for this species.

We further demonstrate the impacts of these decisions on the ranking of potential release sites and present a final set of recommendations that accounts for this uncertainty under both current and future climatic conditions. We specifically identify three sites that are expected to be suitable in both present and future time periods as potential release sites for salamander reintroductions in southwestern Alberta.

Synthesis and applications: Our study adds to our understanding of how different modelling decisions impact SDMs and the downstream conclusions from these models while simultaneously demonstrating a rigorous approach for the use of SDMs in conservation translocation planning.
Working in the office or working from home: Where are employees most creative?
Authors: Rücker Marc , Pakos Oscar , Windschiegl Sophia , Voigt Kai‐Ingo
Published: March 2024

The COVID‐19 pandemic has fundamentally changed how we work. Even after the pandemic, many companies offer their employees the option of working from home. Although working from home may offer several benefits, our understanding of whether employees are more creative when working from home or in an office is limited. To address this research gap, we conducted an experimental study with a German company whose employees usually work in an activity‐based workspace consisting of open, closed and informal spaces that can be used by employees depending on the task at hand. Employees self‐assessed their creative performance for different creative tasks (individual vs. team) and in different work environments (office vs. home office). Our findings reveal that for individual creative tasks (e.g. creating a presentation), employees are more creative when working from home (vs. in the office) because they experience higher levels of perceived psychological freedom (mediating effect). By contrast, for team creative tasks (e.g. developing ideas for a new product), employees reported being more creative when working in the office (vs. from home) due to higher levels of perceived psychological safety (mediating effect). Taken together, these findings enhance our understanding of when and how working from home (vs. in the office) may be beneficial for employees' creativity.
Featured Cover
Authors: Li Xiaokai , Zeng Sha , Chen Li , Zhang Yu , Li Xuemin , Zhang Biwei , Su Duo , Du Qinjiao , Zhang Jiaman , Wang Haoming , Zhong Zhining , Zhang Jinwei , Li Penghao , Jiang Anan , Long Keren , Li Mingzhou , Ge Liangpeng
Published: March 2024

The cover image is based on the Original Article An intronic enhancer of Cebpa regulates adipocyte differentiation and adipose tissue development via long‐range loop formation by Xiaokai Li et al., https://doi.org/10.1111/cpr.13552.

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DHEA: a neglected biological signal that may affect fetal and child development
Authors: Bailey Natasha A. , Davis Elysia Poggi , Sandman Curt A. , Glynn Laura M.
Published: March 2024

Background

The stress‐sensitive maternal hypothalamic–pituitary–adrenal (HPA) axis through the end‐product cortisol, represents a primary pathway through which maternal experience shapes fetal development with long‐term consequences for child neurodevelopment. However, there is another HPA axis end‐product that has been widely ignored in the study of human pregnancy. The synthesis and release of dehydroepiandosterone (DHEA) is similar to cortisol, so it is a plausible, but neglected, biological signal that may influence fetal neurodevelopment. DHEA also may interact with cortisol to determine developmental outcomes. Surprisingly, there is virtually nothing known about human fetal exposure to prenatal maternal DHEA and offspring neurodevelopment. The current study examined, for the first time, the joint impact of fetal exposure to prenatal maternal DHEA and cortisol on infant emotional reactivity.

Methods

Participants were 124 mother–infant dyads. DHEA and cortisol were measured from maternal hair at 15 weeks (early gestation) and 35 weeks (late gestation). Observational assessments of positive and negative emotional reactivity were obtained in the laboratory when the infants were 6 months old. Pearson correlations were used to examine the associations between prenatal maternal cortisol, prenatal maternal DHEA, and infant positive and negative emotional reactivity. Moderation analyses were conducted to investigate whether DHEA might modify the association between cortisol and emotional reactivity.

Results

Higher levels of both early and late gestation maternal DHEA were linked to greater infant positive emotional reactivity. Elevated late gestation maternal cortisol was associated with greater negative emotional reactivity. Finally, the association between fetal cortisol exposure and infant emotional reactivity was only observed when DHEA was low.

Conclusions

These new observations indicate that DHEA is a potential maternal biological signal involved in prenatal programming. It appears to act both independently and jointly with cortisol to determine a child's emotional reactivity. Its role as a primary end‐product of the HPA axis, coupled with the newly documented associations with prenatal development shown here, strongly calls for the inclusion of DHEA in future investigations of fetal programming.
Social Learning and Monetary Policy at the Effective Lower Bound
Authors: ARIFOVIC JASMINA , GRIMAUD ALEX , SALLE ISABELLE , VERMANDEL GAUTHIER
Published: March 2024

This paper develops a model that jointly accounts for the missing disinflation in the wake of the Great Recession and the subsequently observed inflation‐less recovery. The key mechanism works through heterogeneous expectations that may durably lose their anchoring to the central bank (CB)'s target and coordinate on particularly persistent below‐target paths. The welfare cost associated with persistent low inflation may be reduced if the CB announces to the agents its target or its own inflation forecasts, as communication helps coordinate expectations. However, the CB may lose its credibility whenever its announcements become decoupled from actual inflation.
Artificial replication cohort: Leveraging AI‐fabricated data for genetic studies
Authors: Smyk Wiktor , Adrych Krystian , Krawczyk Marcin
Published: March 2024

Recent advancements in artificial intelligence (AI) present both opportunities and challenges within the scientific community. This study explores the capability of AI to replicate findings from genetic research, focusing on findings from prior work. Using an AI model without exposing any raw data, we created a dataset that closely mirrors the results of our original study, illustrating the ease of fabricating datasets with authenticity. This approach highlights the risks associated with AI misuse in scientific research. The study emphasizes the critical importance of maintaining the integrity of scientific inquiry in an era increasingly influenced by advanced AI technologies.
Factors associated with loss to follow‐up in patients with advanced age‐related macular degeneration: A telehealth recall initiative
Authors: Munzar Rachel , Roh Shiyoung , Ramsey David J.
Published: March 2024

Introduction

Patients with advanced age‐related macular degeneration (AMD) frequently experience loss to follow‐up (LTFU), heightening the risk of vision loss from treatment delays. This study aimed to identify factors contributing to LTFU in patients with advanced AMD and assess the effectiveness of telephone‐based outreach in reconnecting them with eye care.

Methods

A custom reporting tool identified patients with advanced AMD who had not returned for eye care between 31 October 2021 and 1 November 2022. Potentially LTFU patients were enrolled in a telephone outreach programme conducted by a telehealth extender to encourage their return for care. Linear regression analysis identified factors associated with being LTFU and likelihood of accepting care post‐outreach.

Results

Out of 1269 patients with advanced AMD, 105 (8.3%) did not return for recommended eye care. Patients LTFU were generally older (89.2 ± 8.9 years vs. 87.2 ± 8.5 years, p = 0.02) and lived farther from the clinic (25 ± 43 miles vs. 17 ± 30 miles, p = 0.009). They also had a higher rate of advanced dry AMD (26.7% vs. 18.5%, p = 0.04) and experienced worse vision in both their better‐seeing (0.683 logMAR vs. 0.566 logMAR, p = 0.03) and worse‐seeing (1.388 logMAR vs. 1.235 logMAR, p = 0.04) eyes. Outreach by a telehealth extender reached 62 patients (59%), 43 through family members or healthcare proxies. Half of the cases where a proxy was contacted revealed that the patient in question had died. Among those contacted directly, one third expressed willingness to resume eye care (20 patients), with 11 scheduling appointments (55%). Despite only two patients returning for in‐person eye care through the intervention, the LTFU rate halved to 4.4% by accounting for those patients who no longer needed eye care at the practice.

Conclusions

There is a substantial risk that older patients with advanced AMD will become LTFU. Targeted telephone outreach can provide a pathway for vulnerable patients to return to care.
Getting what you expect: How civil servant stereotypes affect citizen satisfaction and perceived performance
Authors: Bertram Isa , Bouwman Robin , Tummers Lars
Published: March 2024

This study tests whether civil servant stereotypes affect how citizens experience public service delivery. Using a pre‐registered survey vignette experiment (n = 1130), we activate civil servant stereotypes (negative, positive, or control) and assess whether this affects subsequent perceptions and evaluations of public services. Results indicate that stereotypes shape experiences, with the activation of negative stereotypes leading to lower levels of satisfaction and perceived performance, compared to positive stereotype activation and control. These findings emphasize that negative civil servant stereotypes can have problematic consequences, and contribute to our understanding of the commonly used Expectancy Disconfirmation Model in citizen satisfaction research.
Invisible and indispensable: Using the lowly request for proposals to advance public value
Authors: Merrick Weston , Bernardy Pete , Carter Patrick
Published: March 2024

Requests for Proposals (RFP) may be the pinnacle of bureaucratic mundanity. Yet, hidden within this apparent monotony are powerful tools to advance public values. Federal, state, and local government grants deploy staggering sums, reaching into the hundreds of billions of dollars annually. With these distributions, the executive branch is often delegated substantial discretion. These are choices of consequence, but little support exists for public managers tasked with this work. This article examines the potential to improve administrative decision‐making by enhancing our understanding of how discretion is authorized and applied regarding RFPs. Drawing from professional experience, we create a framework to identify dimensions of discretion in these proposals and apply it to a Minnesota case. We end with a call for academics and practitioners to better partner on empirical inquiry that improves RFP administration; in doing so, there is immense potential to help civil servants to improve outcomes for the public.
Measuring the radiation of sound sources with the radiation mode method: Towards realistic problems
Authors: Sanalatii Maryna , Herzog Philippe , Melon Manuel , Guillermin Régine , Le Roux Jean-Christophe
Published: March 2024

The measurement of the pressure field radiated by a sound source has many applications in the fields of noise control and loudspeaker system design. In this paper, the radiation mode method is used to measure the field radiated by a complex acoustic source whose surface impedance is arbitrary and does not correspond to the Neumann boundary condition used for the calculation of radiation modes. The most effective radiation modes are used as test functions to calculate a pressure expansion around the source under test, an expansion that matches the measured pressure at a limited number of points close to the source. This expansion is then used to calculate the radiated pressure at a greater distance at unmeasured locations. In a first step, numerical simulations are performed to evaluate the method's most influential parameters. Then, measurements are performed in a semi-anechoic room on two real sources of increasing complexity. Obtained results show that the radiation mode method allows an accurate evaluation of the pressure field radiated by the test object over a fairly wide frequency band (between 100 Hz and 2 kHz) even for complex sources.
The FLRT3-UNC5B checkpoint pathway inhibits T cell–based cancer immunotherapies
Authors: Prajapati Kushal , Yan Chuan , Yang Qiqi , Arbitman Steven , Fitzgerald Daniel P. , Sharee Sasan , Shaik Jahangheer , Bosiacki Jason , Myers Kayla , Paucarmayta Ana , Johnson Dorothy M. , O’Neill Thomas , Kundu Subhadip , Cusumano Zachary , Langermann Solomon , Langenau David M. , Patel Shashank , Flies Dallas B.
Published: March 2024

Cancers exploit coinhibitory receptors on T cells to escape tumor immunity, and targeting such mechanisms has shown remarkable clinical benefit, but in a limited subset of patients. We hypothesized that cancer cells mimic noncanonical mechanisms of early development such as axon guidance pathways to evade T cell immunity. Using gain-of-function genetic screens, we profiled axon guidance proteins on human T cells and their cognate ligands and identified fibronectin leucine-rich transmembrane protein 3 (FLRT3) as a ligand that inhibits T cell activity. We demonstrated that FLRT3 inhibits T cells through UNC5B, an axon guidance receptor that is up-regulated on activated human T cells. FLRT3 expressed in human cancers favored tumor growth and inhibited CAR-T and BiTE + T cell killing and infiltration in humanized cancer models. An FLRT3 monoclonal antibody that blocked FLRT3-UNC5B interactions reversed these effects in an immune-dependent manner. This study supports the concept that axon guidance proteins mimic T cell checkpoints and can be targeted for cancer immunotherapy.
Early IGF-1 receptor inhibition in mice mimics preterm human brain disorders and reveals a therapeutic target
Authors: Potenzieri Alberto , Uccella Sara , Preiti Deborah , Pisoni Matteo , Rosati Silvia , Lavarello Chiara , Bartolucci Martina , Debellis Doriana , Catalano Federico , Petretto Andrea , Nobili Lino , Fellin Tommaso , Tucci Valter , Ramenghi Luca A. , Savardi Annalisa , Cancedda Laura
Published: March 2024

Besides recent advances in neonatal care, preterm newborns still develop sex-biased behavioral alterations. Preterms fail to receive placental insulin-like growth factor-1 (IGF-1), a major fetal growth hormone in utero, and low IGF-1 serum levels correlate with preterm poor neurodevelopmental outcomes. Here, we mimicked IGF-1 deficiency of preterm newborns in mice by perinatal administration of an IGF-1 receptor antagonist. This resulted in sex-biased brain microstructural, functional, and behavioral alterations, resembling those of ex-preterm children, which we characterized performing parallel mouse/human behavioral tests. Pharmacological enhancement of GABAergic tonic inhibition by the U.S. Food and Drug Administration–approved drug ganaxolone rescued functional/behavioral alterations in mice. Establishing an unprecedented mouse model of prematurity, our work dissects the mechanisms at the core of abnormal behaviors and identifies a readily translatable therapeutic strategy for preterm brain disorders.
Role of beta-hydroxybutyrate measurement in the evaluation of plasma glucose concentrations in newborn infants
Authors: Stanley Charles A , Weston Philip J , Harris Deborah L , De León Diva D , Harding Jane E
Published: March 2024

Objective

The Glucose in Well Babies (GLOW) Study showed that there are two phases of low glucose concentrations in healthy newborn infants: an initial phase in which plasma concentrations of ketones are low; and a second phase in which low glucose concentrations are accompanied by elevated concentrations of ketones. The implications of these two phases for the brain differ depending on whether ketones are available as alternative substrate for brain metabolism. The purpose of this study was to estimate the duration of these two phases of neonatal low glucose concentrations in 66 healthy breastfed newborns from the GLOW Study during the first 5 days of life.

Methods

The sum of glucose and beta-hydroxybutyrate (BOHB) was used as a proxy for the total concentrations of insulin-dependent fuels for the brain; a threshold value below 4 mmol/L was taken to indicate the presence of relative hyperinsulinism and a BOHB concentration above 0.5 mmol/L to indicate ketonaemia.

Results

The first phase of low glucose concentrations lasted a median of 40 hours and in 15% of infants, this persisted beyond 60 hours. Fifty (76%) of the 66 infants subsequently had ketonaemia, which resolved at a median age of 76 hours (range 41–>120 hours).

Conclusions

These data suggest that monitoring BOHB concentrations may be useful for interpreting glucose concentrations in newborns and screening for persistent hyperinsulinism.
Association of Endogenous Seminal L‐Carnitine Levels with Post‐Thaw Semen Parameters in Humans
Authors: Iliceto Mario , Andersen Jorunn M. , Stensen Mette Haug , Haugen Trine B. , Witczak Oliwia
Published: March 2024

Cryopreservation of semen is a useful tool for male fertility preservation. Some evidence for a beneficial effect of L‐carnitine supplementation of freezing media on cryopreserved semen samples has been reported. Here, we examined the association of endogenous levels of seminal L‐carnitine with post‐thaw semen parameters. We also investigated the effect of freezing medium supplemented with L‐carnitine on sperm characteristics, related to endogenous seminal L‐carnitine levels. Semen analyses were performed on 125 fresh samples, and after standard cryopreservation and with L‐carnitine as a supplement. Participants were categorized into two groups based on the median levels of endogenous seminal L‐carnitine: low L‐carnitine (≤38.8 µg/ml) and high L‐carnitine (>38.8 µg/ml). After standard cryopreservation, semen samples with high L‐carnitine levels showed higher rapid progressive, progressive and total sperm motility and a reduced seminal static oxidation–reduction potential (ORP) level than samples with low L‐carnitine levels. Only in post‐thaw samples with low L‐carnitine levels, there was an increase in the amount of sperm neck midpiece defects, compared to the fresh samples. Cryopreservation with L‐carnitine had the most beneficial effect on rapid progressive sperm motility in samples with high endogenous L‐carnitine levels. In conclusion, L‐carnitine has a beneficial impact on sperm characteristics in post‐thaw samples both as an endogenous component in seminal plasma and as a supplement in the freezing medium, by improving sperm motility and reducing seminal oxidative stress.
Unusual Coincidence: Concurrent Cast Nephropathy and Lymphoma Infiltration in an Influenza A-Associated Acute Kidney Injury
Authors: Lee Wan-Ching , Tsai Chun-Kuang , Li Szu-Yuan
Published: March 2024

Acute kidney injury (AKI) poses a substantial challenge in the management of lymphoma patients and is frequently associated with diverse causative factors. Herein, we report an illustrative case involving a 47-year-old male with influenza A infection who developed severe AKI, which was incongruent with his medical history. Laboratory investigations disclosed aberrant immunoglobulin levels and urinary protein excretion, prompting further evaluation. A renal biopsy revealed the presence of infiltrating lymphoid cells and cast nephropathy, raising suspicion of an underlying hematological disorder. A comprehensive diagnostic workup, including positron emission tomography imaging and bone marrow biopsy, culminated in the definitive diagnosis of splenic marginal zone lymphoma. This case highlights the crucial significance of including lymphoma-associated kidney disorders in the evaluation of unexplained AKI, particularly when encountering unconventional clinical and laboratory results. Swift and precise intervention is of utmost importance in attaining positive results in these rare and complex clinical situations. This study underscores the persistent concern of AKI in lymphoma patients, with lymphocytic infiltration and cast nephropathy as notable elements contributing to the intricate nature of this condition.
Effect of the AADE7 Self-Care Behaviors Framework on Diabetes Education Management in a Shared Care Model
Authors: Liu Yunxia , Liu Chenhui
Published: March 2024

Background. Diabetes self-management education (DSME) provides diabetic patients with knowledge of diabetes, requires attention and recording of dietary habits, and increases the frequency and accuracy of blood glucose monitoring. DSME also achieves better blood glucose control, thus benefiting diabetic patients and reducing the risk of diabetes complications. However, few studies have systematically examined whether DSME follows AADE 7 Self-Care Behaviors (AADE7™). Therefore, this study aimed to investigate the control effect of AADE7™-based management on laboratory test indicators of diabetic patients. Methods. The patients with diabetes who received shared care management in our hospital between June 2014 and April 2022 were analyzed retrospectively. According to the process of outpatient consultation, each patient received health education provided by diabetes education nurses and dietitians after consultation. Health education was a process from assessment to health guidance. The basic information of all patients was recorded, and AADE7™ behavior assessment and health education session were conducted through interviews. A total of 13,650 were given shared care management, requiring more than 6 follow-up visits per year, as well as health education. It was reassessed annually according to AADE standards. The impact of the patients’ behavior change after the AADE7™-based management on the relevant test indicators was observed. Results. After eight years of intervention, a total of 8319 samples were obtained after excluding the outliers. Stepwise regression analysis was performed, and the results showed that, with other conditions held constant, a greater number of days per week to follow a healthy diet, to take hypoglycemic medication as prescribed, to monitor blood glucose, and to exercise and higher education level were associated with lower levels of glycosylated hemoglobin. The change from drinking to nondrinking was associated with lower triglycerides. If low blood glucose was monitored, patients who reviewed and took immediate action showed lower levels of low-density lipoprotein, urine microalbumin, and urine microalbumin/creatinine ratio compared with those without review and immediate action. Significance tests for each term showed P value <0.05. Conclusions. The AADE7™ framework is a tool supporting patient-centered self-management and education. In the AADE7™ standards, successful self-management is considered as a key outcome in the care of patients with diabetes and related diseases. This tool can effectively improve patient compliance and increase the rate of blood glucose compliance rates in patients with diabetes and therefore is worthy of clinical promotion.
Semisupervised Vector Quantization in Visual SLAM Using HGCN
Authors: Zarringhalam Amir , Shiry Ghidary Saeid , Mohades Ali , Sadegh-Zadeh Seyed-Ali
Published: March 2024

We present a novel vector quantization (VQ) module for the two state-of-the-art long-range simultaneous localization and mapping (SLAM) algorithms. The VQ task in SLAM is generally performed using unsupervised methods. We provide an alternative approach trough embedding a semisupervised hyperbolic graph convolutional neural network (HGCN) in the VQ step of the SLAM processes. The SLAM platforms we have utilized for this purpose are fast appearance-based mapping (FABMAP) and oriented fast and rotated short (ORB), both of which rely on extracting the features of the captured images in their loop closure detection (LCD) module. For the first time, we have considered the space formed by these SURF features, robust image descriptors, as a graph, enabling us to apply an HGCN in the VQ section which results in an improved LCD performance. The HGCN vector quantizes the SURF feature space, leading to a bag-of-word (BoW) representation construction of the images. This representation is subsequently used to determine LCD accuracy and recall. Our approaches in this study are referred to as HGCN-FABMAP and HGCN-ORB. The main advantage of using HGCN in the LCD section is that it scales linearly when the features are accumulated. The benchmarking experiments show the superiority of our methods in terms of both trajectory generation accuracy in small-scale paths and LCD accuracy and recall for large-scale problems.
Supplementary Table S3 from Maternal Prenatal Use of Alcohol, Tobacco, and Illicit Drugs and Associations with Childhood Cancer Subtypes
Authors: Wimberly Courtney E. , Gulrajani Natalie B. , Russ Jeffrey B. , Landi Daniel , Wiemels Joseph L. , Towry Lisa , Wiencke John K. , Walsh Kyle M.
Published: March 2024

Associations between prenatal substance use and childhood cancer subtype in subset of biological mother respondents
Supplementary Materials and Methods from Maternal Prenatal Use of Alcohol, Tobacco, and Illicit Drugs and Associations with Childhood Cancer Subtypes
Authors: Wimberly Courtney E. , Gulrajani Natalie B. , Russ Jeffrey B. , Landi Daniel , Wiemels Joseph L. , Towry Lisa , Wiencke John K. , Walsh Kyle M.
Published: March 2024

Supplementary File 1 - contains MCC Diagnosis Survey
Supplementary Table S7 from Lung Cancer in Ever- and Never-Smokers: Findings from Multi-Population GWAS Studies
Authors: Li Yafang , Xiao Xiangjun , Li Jianrong , Han Younghun , Cheng Chao , Fernandes Gail F. , Slewitzke Shannon E. , Rosenberg Susan M. , Zhu Meng , Byun Jinyoung , Bossé Yohan , McKay James D. , Albanes Demetrios , Lam Stephen , Tardon Adonina , Chen Chu , Bojesen Stig E. , Landi Maria T. , Johansson Mattias , Risch Angela , Bickeböller Heike , Wichmann H-Erich , Christiani David C. , Rennert Gad , Arnold Susanne M. , Goodman Gary E. , Field John K. , Davies Michael P.A. , Shete Sanjay , Marchand Loïc Le , Liu Geoffrey , Hung Rayjean J. , Andrew Angeline S. , Kiemeney Lambertus A. , Sun Ryan , Zienolddiny Shanbeh , Grankvist Kjell , Johansson Mikael , Caporaso Neil E. , Cox Angela , Hong Yun-Chul , Lazarus Philip , Schabath Matthew B. , Aldrich Melinda C. , Schwartz Ann G. , Gorlov Ivan , Purrington Kristen S. , Yang Ping , Liu Yanhong , Bailey-Wilson Joan E. , Pinney Susan M. , Mandal Diptasri , Willey James C. , Gaba Colette , Brennan Paul , Xia Jun , Shen Hongbing , Amos Christopher I.
Published: March 2024

Supplementary Table S7 shows the signals from interaction with smoking status for the identified variants in lung cancer.
Supplementary Table 2 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk
Authors: Stern Mariana C. , Sanchez Mendez Joel , Kim Andre E. , Obón-Santacana Mireia , Moratalla-Navarro Ferran , Martín Vicente , Moreno Victor , Lin Yi , Bien Stephanie A. , Qu Conghui , Su Yu-Ru , White Emily , Harrison Tabitha A. , Huyghe Jeroen R. , Tangen Catherine M. , Newcomb Polly A. , Phipps Amanda I. , Thomas Claire E. , Kawaguchi Eric S. , Lewinger Juan Pablo , Morrison John L. , Conti David V. , Wang Jun , Thomas Duncan C. , Platz Elizabeth A. , Visvanathan Kala , Keku Temitope O. , Newton Christina C. , Um Caroline Y. , Kundaje Anshul , Shcherbina Anna , Murphy Neil , Gunter Marc J. , Dimou Niki , Papadimitriou Nikos , Bézieau Stéphane , van Duijnhoven Franzel J.B. , Männistö Satu , Rennert Gad , Wolk Alicja , Hoffmeister Michael , Brenner Hermann , Chang-Claude Jenny , Tian Yu , Le Marchand Loïc , Cotterchio Michelle , Tsilidis Konstantinos K. , Bishop D. Timothy , Melaku Yohannes Adama , Lynch Brigid M. , Buchanan Daniel D. , Ulrich Cornelia M. , Ose Jennifer , Peoples Anita R. , Pellatt Andrew J. , Li Li , Devall Matthew A.M. , Campbell Peter T. , Albanes Demetrius , Weinstein Stephanie J. , Berndt Sonja I. , Gruber Stephen B. , Ruiz-Narvaez Edward , Song Mingyang , Joshi Amit D. , Drew David A. , Petrick Jessica L. , Chan Andrew T. , Giannakis Marios , Peters Ulrike , Hsu Li , Gauderman W. James
Published: March 2024

Sensitivity analysis from genome-wide interaction scans to evaluate the potential impact of adjusting for the variable body mass index in the significance of the two SNPs that we reported.
Supplementary Figure 4 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk
Authors: Stern Mariana C. , Sanchez Mendez Joel , Kim Andre E. , Obón-Santacana Mireia , Moratalla-Navarro Ferran , Martín Vicente , Moreno Victor , Lin Yi , Bien Stephanie A. , Qu Conghui , Su Yu-Ru , White Emily , Harrison Tabitha A. , Huyghe Jeroen R. , Tangen Catherine M. , Newcomb Polly A. , Phipps Amanda I. , Thomas Claire E. , Kawaguchi Eric S. , Lewinger Juan Pablo , Morrison John L. , Conti David V. , Wang Jun , Thomas Duncan C. , Platz Elizabeth A. , Visvanathan Kala , Keku Temitope O. , Newton Christina C. , Um Caroline Y. , Kundaje Anshul , Shcherbina Anna , Murphy Neil , Gunter Marc J. , Dimou Niki , Papadimitriou Nikos , Bézieau Stéphane , van Duijnhoven Franzel J.B. , Männistö Satu , Rennert Gad , Wolk Alicja , Hoffmeister Michael , Brenner Hermann , Chang-Claude Jenny , Tian Yu , Le Marchand Loïc , Cotterchio Michelle , Tsilidis Konstantinos K. , Bishop D. Timothy , Melaku Yohannes Adama , Lynch Brigid M. , Buchanan Daniel D. , Ulrich Cornelia M. , Ose Jennifer , Peoples Anita R. , Pellatt Andrew J. , Li Li , Devall Matthew A.M. , Campbell Peter T. , Albanes Demetrius , Weinstein Stephanie J. , Berndt Sonja I. , Gruber Stephen B. , Ruiz-Narvaez Edward , Song Mingyang , Joshi Amit D. , Drew David A. , Petrick Jessica L. , Chan Andrew T. , Giannakis Marios , Peters Ulrike , Hsu Li , Gauderman W. James
Published: March 2024

Locus Zoom plots for the two polymorphisms reported in the genome-wide gene-interaction main results.
Table S6 from Mitochondrial DNA Haplogroups and SNPs: Risk Factors in Multiple Cancers Based on a Cross-Tumor Analysis in Chinese Population
Authors: Chen Dongbo , Yan Zeyu , Yuan Qing , Xie Fanfan , Liu Yang , Feng Zehui , Wang Zhenni , Zhou Feng , Xing Jinliang , Zhang Zhaohui , Wang Fuli , Guo Xu
Published: March 2024

Stratified and interaction analysis of mtSNPs-based risk score in multiple types of cancer of public external validation set.
Supplementary Figure 3 from Genome-Wide Gene–Environment Interaction Analyses to Understand the Relationship between Red Meat and Processed Meat Intake and Colorectal Cancer Risk
Authors: Stern Mariana C. , Sanchez Mendez Joel , Kim Andre E. , Obón-Santacana Mireia , Moratalla-Navarro Ferran , Martín Vicente , Moreno Victor , Lin Yi , Bien Stephanie A. , Qu Conghui , Su Yu-Ru , White Emily , Harrison Tabitha A. , Huyghe Jeroen R. , Tangen Catherine M. , Newcomb Polly A. , Phipps Amanda I. , Thomas Claire E. , Kawaguchi Eric S. , Lewinger Juan Pablo , Morrison John L. , Conti David V. , Wang Jun , Thomas Duncan C. , Platz Elizabeth A. , Visvanathan Kala , Keku Temitope O. , Newton Christina C. , Um Caroline Y. , Kundaje Anshul , Shcherbina Anna , Murphy Neil , Gunter Marc J. , Dimou Niki , Papadimitriou Nikos , Bézieau Stéphane , van Duijnhoven Franzel J.B. , Männistö Satu , Rennert Gad , Wolk Alicja , Hoffmeister Michael , Brenner Hermann , Chang-Claude Jenny , Tian Yu , Le Marchand Loïc , Cotterchio Michelle , Tsilidis Konstantinos K. , Bishop D. Timothy , Melaku Yohannes Adama , Lynch Brigid M. , Buchanan Daniel D. , Ulrich Cornelia M. , Ose Jennifer , Peoples Anita R. , Pellatt Andrew J. , Li Li , Devall Matthew A.M. , Campbell Peter T. , Albanes Demetrius , Weinstein Stephanie J. , Berndt Sonja I. , Gruber Stephen B. , Ruiz-Narvaez Edward , Song Mingyang , Joshi Amit D. , Drew David A. , Petrick Jessica L. , Chan Andrew T. , Giannakis Marios , Peters Ulrike , Hsu Li , Gauderman W. James
Published: March 2024

Plots for the association of red meat intake and colorectal cancer risk stratified by the genotypes of the two SNPs obtained from genome-wide interaction analysis.
Table S2 from Mitochondrial DNA Haplogroups and SNPs: Risk Factors in Multiple Cancers Based on a Cross-Tumor Analysis in Chinese Population
Authors: Chen Dongbo , Yan Zeyu , Yuan Qing , Xie Fanfan , Liu Yang , Feng Zehui , Wang Zhenni , Zhou Feng , Xing Jinliang , Zhang Zhaohui , Wang Fuli , Guo Xu
Published: March 2024

Analysis of association between mtDNA haplogroups and occurrence risk in multiple types of cancer when referring to haplogroup D.
Figure S2 from Mitochondrial DNA Haplogroups and SNPs: Risk Factors in Multiple Cancers Based on a Cross-Tumor Analysis in Chinese Population
Authors: Chen Dongbo , Yan Zeyu , Yuan Qing , Xie Fanfan , Liu Yang , Feng Zehui , Wang Zhenni , Zhou Feng , Xing Jinliang , Zhang Zhaohui , Wang Fuli , Guo Xu
Published: March 2024

The frequencies of mtDNA haplogroups among public data HC and in-house data HC are shown in Table S1. The PCA plot revealed that the combined frequency of components 1 and 2 was 81.7%. In component 1, in-house data HC and in-house data sup HC are more closely associated with public data HC (Shaanxi). In component 2, in-house data HC and in-house data sup HC are more closely related to public data HC (Guangzhou).
Table S1 from Hematocrit Is Associated with Cancer-Related Fatigue in Colorectal Cancer Survivors: A Longitudinal Analysis
Authors: Kiebach Joann , de Vries-ten Have Judith , van Duijnhoven Fränzel J.B. , Kok Dieuwertje E. , van Lanen Anne-Sophie , Kouwenhoven Ewout A. , de Wilt Johannes H.W. , Schrauwen Ruud W.M. , Kampman Ellen , Winkels Renate M. , Wesselink Evertine
Published: March 2024

: Baseline characteristics of included CRC survivors (n=1,506) and excluded survivors (n=624)
Supplementary Table 1 from Physical Activity and Mammographic Density in Japanese Women
Authors: Lee Mihye , Kotake Rina , Yamauchi Hideko
Published: March 2024

Supplementary Table S1. Comparison of Correlation Structures.
Data from Marital Status, Living Arrangement, and Survival among Individuals with Advanced Prostate Cancer in the International Registry for Men with Advanced Prostate Cancer
Authors: Chen Naiyu , McGrath Colleen B. , Ericsson Caroline I. , Vaselkiv Jane B. , Rencsok Emily M. , Stopsack Konrad H. , Guard Hannah E. , Autio Karen A. , Rathkopf Dana E. , Enting Deborah , Bitting Rhonda L. , Mateo Joaquin , Githiaka Charles W. , Chi Kim N. , Cheng Heather H. , Davis Ian D. , Anderson Simon G. , Badal Simone Ann Marie , Bjartell Anders , Russnes Kjell M. , Heath Elisabeth I. , Pomerantz Mark M. , Henegan John C. , Hyslop Terry , Esteban Emilio , Omlin Aurelius , McDermott Ray , Fay Andre P. , Popoola Ademola Alabi , Ragin Camille , Nowak Joel , Gerke Travis , Kantoff Philip W. , George Daniel J. , Penney Kathryn L. , Mucci Lorelei A.
Published: March 2024

AbstractBackground:
Studies have shown improved survival among individuals with cancer with higher levels of social support. Few studies have investigated social support and overall survival (OS) in individuals with advanced prostate cancer in an international cohort. We investigated the associations of marital status and living arrangements with OS among individuals with advanced prostate cancer in the International Registry for Men with Advanced Prostate Cancer (IRONMAN).
Methods:
IRONMAN is enrolling participants diagnosed with advanced prostate cancer (metastatic hormone-sensitive prostate cancer, mHSPC; castration-resistant prostate cancer, CRPC) from 16 countries. Participants in this analysis were recruited between July 2017 and January 2023. Adjusting for demographics and tumor characteristics, the associations were estimated using Cox regression and stratified by disease state (mHSPC, CRPC), age (<70, ≥70 years), and continent of enrollment (North America, Europe, Other).
Results:
We included 2,119 participants with advanced prostate cancer, of whom 427 died during up to 5 years of follow-up (median 6 months). Two-thirds had mHSPC. Most were married/in a civil partnership (79%) and 6% were widowed. Very few married participants were living alone (1%), while most unmarried participants were living alone (70%). Married participants had better OS than unmarried participants [adjusted HR: 1.44; 95% confidence interval (CI): 1.02–2.02]. Widowed participants had the worst survival compared with married individuals (adjusted HR: 1.89; 95% CI: 1.22–2.94).
Conclusions:
Among those with advanced prostate cancer, unmarried and widowed participants had worse OS compared with married participants.
Impact:
This research highlighted the importance of social support in OS within this vulnerable population.
Data from Physical Activity and Mammographic Density in Japanese Women
Authors: Lee Mihye , Kotake Rina , Yamauchi Hideko
Published: March 2024

AbstractBackground:
Dense breast is one of the strong risk factors for breast cancer among women. While it has been established that physical activity is associated with decreased risk for breast cancer, results have been inconsistent in terms of mammographic density. Thus, we examined physical activity in relation to mammographic density among Japanese women in Tokyo.
Methods:
We used 123,026 records from 33,698 Japanese women without a history of breast cancer who got mammograms at St. Luke's International Hospital in Tokyo, Japan from 2004 to 2019. Mammographic density was classified according to the Breast Imaging Reporting and Data System (BI-RADS), and women self-reported their physical activity level over the past year. ORs were estimated using logistic generalized estimating equations after adjusting for age, body mass index, menopausal status, parity, family history of breast or ovarian cancer, hormone therapy use, smoking status, alcohol consumption, and year.
Results:
We observed inverse associations of physical activity with dense breasts. Adjusted ORs were 0.96 (95% confidence interval: 0.91–1.00) for women with physical exercise for 1–2 days per week, 0.94 (0.88–0.99) for those with physical exercise for 3–5 days per week, and 0.91 (0.84–0.99) for those with daily physical exercise when compared with those reported seldom physical exercise.
Conclusions:
Higher levels of physical activity may be associated with decreased mammographic density levels in Japanese women.
Impact:
Increasing physical activity may serve as a reasonable intervention to reduce mammographic density, and thereby, to mitigate the risk of breast cancer in Asian women.
Supplementary Table S2 from GATA-3–dependent Gene Transcription is Impaired upon HDAC Inhibition
Authors: Geng Xiangrong , Wang Chenguang , Abdelrahman Suhaib , Perera Thilini , Saed Badeia , Hu Ying S. , Wolfe Ashley , Reneau John , Murga-Zamalloa Carlos , Wilcox Ryan A.
Published: March 2024

List of HDACi regulated pathways
Supplementary Figure S5 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

Expression of known EwS surface proteins in cell line models and publicly available data.
Supplementary Figure S4 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

Correlation between surfaceome and global proteome datasets.
Supplementary Figure S11 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

ENPP1 and CDH11 have high EwS dependency.
Supplementary Data S4 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

Relative abundance values for proteins identified by proteomics.
Supplementary Data S3 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

Scoring schema to prioritize candidate immunotherapy targets.
Supplementary Data S2 from Surface and Global Proteome Analyses Identify ENPP1 and Other Surface Proteins as Actionable Immunotherapeutic Targets in Ewing Sarcoma
Authors: Mooney Brian , Negri Gian Luca , Shyp Taras , Delaidelli Alberto , Zhang Hai-Feng , Spencer Miko Sandra E. , Weiner Amber K. , Radaoui Alexander B. , Shraim Rawan , Lizardo Michael M. , Hughes Christopher S. , Li Amy , El-Naggar Amal M. , Rouleau Melanie , Li Wei , Dimitrov Dimiter S. , Kurmasheva Raushan T. , Houghton Peter J. , Diskin Sharon J. , Maris John M. , Morin Gregg B. , Sorensen Poul H.
Published: March 2024

Statistical analysis (DEqMS) of proteins, EwS vs SuperMix