bluuebunny/crossref_metadata_2025 huggingface dataset:
Down‐regulation of cathepsin K in synovium leads to progression of osteoarthritis in rabbits
Authors: Takahashi Daisuke , Iwasaki Norimasa , Kon Shigeyuki , Matsui Yuichiro , Majima Tokifumi , Minami Akio , Uede Toshimitsu
Published: July 2009

Objective

The hypothesis of this study was that synovial factors playing a pivotal role in the pathogenesis of osteoarthritis (OA) and thus gene expression in the synovium would be altered at the initial stage of OA. The aims of this study were to identify the candidate genes in synovium related to OA initiation, to evaluate cartilage degeneration after knockdown of the gene using small interfering RNA (siRNA) gene silencing in the knee joints at the initial stage of OA, and to determine the potential role of the knocked‐down gene in OA initiation.

Methods

Genes overexpressed in synovium at the initial stage of disease in a rabbit model of anterior cruciate ligament transection (ACLT)–induced OA were identified using the suppression subtractive hybridization technique and differential screening. Candidate gene expression in the synovium of the knees of rabbits with OA was manipulated with electroporation‐assisted siRNA transduction 4 times before and after operation. Four weeks after surgery, histologic analysis was performed.

Results

Cathepsin K gene and protein expression was significantly up‐regulated in synovium at the initial stage of OA in rabbits. Down‐regulation of cathepsin K in synovium at the initial stage of OA significantly accelerated cartilage degeneration.

Conclusion

These results indicate that cathepsin K plays a protective role in cartilage degeneration at the initial stage of OA. We believe that the current results obtained from models of the early phase of OA will provide useful information for developing a novel strategy to prevent disease progression.
Comparing a rule‐based versus statistical system for automatic categorization of MEDLINE documents according to biomedical specialty
Authors: Humphrey Susanne M. , Névéol Aurélie , Browne Allen , Gobeil Julien , Ruch Patrick , Darmoni Stéfan J.
Published: July 2009

Automatic document categorization is an important research problem in Information Science and Natural Language Processing. Many applications, including, Word Sense Disambiguation and Information Retrieval in large collections, can benefit from such categorization. This paper focuses on automatic categorization of documents from the biomedical literature into broad discipline‐based categories. Two different systems are described and contrasted: CISMeF, which uses rules based on human indexing of the documents by the Medical Subject Headings (MeSH) controlled vocabulary in order to assign metaterms (MTs), and Journal Descriptor Indexing (JDI), based on human categorization of about 4,000 journals and statistical associations between journal descriptors (JDs) and textwords in the documents. We evaluate and compare the performance of these systems against a gold standard of humanly assigned categories for 100 MEDLINE documents, using six measures selected from trec_eval. The results show that for five of the measures performance is comparable, and for one measure JDI is superior. We conclude that these results favor JDI, given the significantly greater intellectual overhead involved in human indexing and maintaining a rule base for mapping MeSH terms to MTs. We also note a JDI method that associates JDs with MeSH indexing rather than textwords, and it may be worthwhile to investigate whether this JDI method (statistical) and CISMeF (rule‐based) might be combined and then evaluated showing they are complementary to one another.
When stopword lists make the difference
Authors: Dolamic Ljiljana , Savoy Jacques
Published: July 2009

In this brief communication, we evaluate the use of two stopword lists for the English language (one comprising 571 words and another with 9) and compare them with a search approach accounting for all word forms. We show that through implementing the original Okapi form or certain ones derived from the Divergence from Randomness (DFR) paradigm, significantly lower performance levels may result when using short or no stopword lists. For other DFR models and a revised Okapi implementation, performance differences between approaches using short or long stopword lists or no list at all are usually not statistically significant. Similar conclusions can be drawn when using other natural languages such as French, Hindi, or Persian.
Mechanisms responsible for the altered pharmacokinetics of Bosentan: analysis utilizing rats with bile duct ligation‐induced liver dysfunction
Authors: Horiuchi Isao , Mori Yun‐i , Taguchi Masato , Ichida Fukiko , Miyawaki Toshio , Hashimoto Yukiya
Published: July 2009

The purpose of this study was to evaluate the mechanisms responsible for the pharmacokinetic variability of bosentan utilizing rats with liver dysfunction induced by 7‐day bile duct ligation (BDL). Bosentan was administered intravenously at a constant infusion rate (I) of 24, 40 or 60 µg/min/kg. The blood bosentan concentration (BBC) following infusion was measured by HPLC, and apparent clearance (CL) of the drug was estimated asI/BBC. TheCLvalues in normal rats were 30.5 and 19.3 ml/min/kg at infusion rates of 24 and 60 µg/min/kg, respectively, suggesting non‐linear pharmacokinetics of bosentan. TheBBCin BDL rats was much higher than that in normal rats, and theCLvalues in BDL rats were 3.80 and 3.08 ml/min/kg at infusion rates of 24 and 60 µg/min/kg, respectively. TheCLvalue of bosentan at an infusion rate of 40 µg/min/kg in normal rats was decreased significantly by the coadministration of taurocholic acid or bilirubin. In addition, the hepatic mRNA expression of CYP2C6, CYP3A2, Oatp1a1, Oatp1a4 and Oatp1b2 in BDL rats decreased to 77.6%, 34.0%, 65.4%, 84.8% and 44.2% of that in normal rats, respectively. These results suggested that bile acids and/or bilirubin accumulated in BDL rat plasma inhibited the hepatic uptake of bosentan, and that the decreased bosentan clearance in BDL rats was caused at least partly by the impaired expression of hepatic drug‐metabolizing enzymes and uptake transporters. Moreover, because the pharmacokinetics of bosentan was non‐linear at the tested doses, the increasedBBCin BDL rats might further induce the saturation of hepatic uptake and/or metabolism of bosentan. Copyright © 2009 John Wiley & Sons, Ltd.
Genomic mutation rates: what high‐throughput methods can tell us
Authors: Nishant Koodali T. , Singh Nadia D. , Alani Eric
Published: July 2009

High‐throughput DNA analyses are increasingly being used to detect rare mutations in moderately sized genomes. These methods have yielded genome mutation rates that are markedly higher than those obtained using pre‐genomic strategies. Recent work in a variety of organisms has shown that mutation rate is strongly affected by sequence context and genome position. These observations suggest that high‐throughput DNA analyses will ultimately allow researchers to identify trans‐acting factors and cis sequences that underlie mutation rate variation. Such work should provide insights on how mutation rate variability can impact genome organization and disease progression.
Characterisation of normal and cancer stem cells: One experimental paradigm for two kinds of stem cells
Authors: Mayol Jean‐François , Loeuillet Corinne , Hérodin Francis , Wion Didier
Published: July 2009

The characterisation of normal stem cells and cancer stem cells uses the same paradigm. These cells are isolated by a fluorescence‐activated cell sorting step and their stemness is assayed following implantation into animals. However, differences exist between these two kinds of stem cells. Therefore, the translation of the experimental procedures used for normal stem cell isolation into the research field of cancer stem cells is a potential source of artefacts. In addition, normal stem cell therapy has the objective of regenerating a tissue, while cancer stem cell‐centred therapy seeks the destruction of the cancer tissue. Taking these differences into account is critical for anticipating problems that might arise in cancer stem cell‐centred therapy and for upgrading the cancer stem cell paradigm accordingly.
Incomplete penetrance and variable expressivity: is there a microRNA connection?
Authors: Ahluwalia Jasmine K. , Hariharan Manoj , Bargaje Rhishikesh , Pillai Beena , Brahmachari Vani
Published: July 2009

Incomplete penetrance and variable expressivity are non‐Mendelian phenomena resulting in the lack of correlation between genotype and phenotype. Not withstanding the diversity in mechanisms, differential expression of homologous alleles within cells manifests as variations in penetrance and expressivity of mutations between individuals of the same genotype. These phenomena are seen most often in dominantly inherited diseases, implying that they are sensitive to concentration of the gene product. In this framework and the advances in understanding the role of microRNA (miRNA) in fine‐tuning gene expression at translational level, we propose miRNA‐mediated regulation as a mechanism for incomplete penetrance and variable expressivity. The presence of miRNA binding sites at 3′ UTR, co‐expression of target gene–miRNA pairs for genes showing incomplete penetrance and variable expressivity derived from available data lend support to our hypothesis. Single nucleotide polymorphisms in the miRNA target site facilitate the implied differential targeting of the transcripts from homologous alleles.
Electron microscopy of helical filaments: rediscovering buried treasures in negative stain
Authors: Egelman Edward H. , Amos Linda A.
Published: July 2009

Although negative stain electron microscopy is a wonderfully simple way of directly visualizing protein complexes and other biological macromolecules, the images are not really comparable to those of objects seen in everyday life. The failure to appreciate this has recently led to an incorrect interpretation of RecA‐family filament structures.
Diverse modes of 5′‐[4‐(aminoiminomethyl)phenyl]‐[2,2′‐bifuran]‐5‐carboximidamide (DB832) interaction with multi‐stranded DNA structures
Authors: Kaluzhny Dmitry N. , Borisova Olga F. , Shchyolkina Anna K.
Published: July 2009

The modes of binding of 5′‐[4‐(aminoiminomethyl)phenyl]‐[2,2′‐Bifuran]‐5‐carboximidamide (DB832) to multi‐stranded DNAs: human telomere quadruplex, monomolecular R‐triplex, pyr/pur/pyr triplex consisting of 12 T*(T·A) triplets, and DNA double helical hairpin were studied. The optical adsorption of the ligand was used for monitoring the binding and for determination of the association constants and the numbers of binding sites. CD spectra of DB832 complexes with the oligonucleotides and the data on the energy transfer from DNA bases to the bound DB832 assisted in elucidating the binding modes. The affinity of DB832 to the studied multi‐stranded DNAs was found to be greater (Kass ≈ 107M−1) than to the duplex DNA (Kass ≈ 2 × 105M−1). A considerable stabilizing effect of DB832 binding on R‐triplex conformation was detected. The nature of the ligand tight binding differed for the studied multi‐stranded DNA depending on their specific conformational features: recombination‐type R‐triplex demonstrated the highest affinity for DB832 groove binding, while pyr/pur/pyr TTA triplex favored DB832 intercalation at the end stacking contacts and the human telomere quadruplex d[AG3(T2AG3)3] accommodated the ligand in a capping mode. Additionally, the pyr/pur/pyr TTA triplex and d[AG3(T2AG3)3] quadruplex bound DB832 into their grooves, though with a markedly lesser affinity. DB832 may be useful for discrimination of the multi‐sranded DNA conformations and for R‐triplex stabilization. © 2009 Wiley Periodicals, Inc. Biopolymers 93: 8–20, 2010.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Simultaneous determination of β2‐agonists in human urine by fast‐gas chromatography/mass spectrometry: method validation and clinical application
Authors: Di Corcia Daniele , Morra Veronica , Pazzi Marco , Vincenti Marco
Published: July 2009

A fast screening protocol was developed and validated for the simultaneous determination of 15 β2‐agonists in human urine (bambuterol, cimbuterol, clenbuterol, fenoterol, formoterol, isoproterenol, mapenterol, metaproterenol, procaterol, ractopamine, ritodrine, salbutamol, salmeterol, terbutaline, tulobuterol). The overall sample processing includes deconjugation with enzyme hydrolysis, liquid–liquid extraction, followed by derivatization of the extract and detection of β2‐agonists trimethylsilyl‐derivatives by fast‐gas chromatography/electron impact–mass spectrometry (fast‐GC/EI‐MS). Sample extraction and derivatization were optimized with the purpose of improving recoveries and reaction yields for a variety of analytes with different structures simultaneously, while keeping the procedure simple and reliable. Validation parameters were determined for each analyte under investigation, including selectivity, linearity, intra‐ and inter‐assay precision, extraction recoveries and signal to noise ratio (S/N) at the lowest calibration level. Fast‐GC/MS sequences, based on the use of short columns, high carrier‐gas velocity and fast temperature ramping, allow considerable reduction of the analysis time (7 min), while maintaining adequate chromatographic resolution. The overall GC cycle time was less than 9 min, allowing a processing rate of 6 samples/h. High MS‐sampling rate, using a benchtop quadrupole mass analyzer, resulted in accurate peak shape definition under both scan and selected ion monitoring modes, and high sensitivity in the latter mode. The method was successfully tested on real samples arising from clinical treatments. Copyright © 2009 John Wiley & Sons, Ltd.
Fetal topohistology of the mesocolon transversum with special reference to fusion with other mesenteries and fasciae
Authors: Jeong Yeon Jun , Cho Baik Hwan , Kinugasa Yusuke , Song Chang Ho , Hirai Ichiro , Kimura Wataru , Fujimiya Mineko , Murakami Gen
Published: July 2009

The developing mesocolon transversum was investigated using hematoxylin and eosin‐stained semiserial sections derived from 17 human fetuses between 12 and 30 weeks of gestation. The mesocolon was attached to the mesoduodenum and greater omentum until 12 weeks. However, the fetal duodenal attachment appeared not to correspond to the right colic flexure in adults. The greater omentum and mesocolon were likely to be irregularly folded at the attachment site possibly because the developing transverse colon “ran into” and pushed up the greater omentum and pancreatic head. Lymphatic vessels invaded the indistinct fusion plane to destroy the primary configuration. Moreover, the mesocolon seemed to “seize” or take‐over some parts of the splenic side of the greater omentum, but the thick gastric side containing the right gastroepiploic artery and vein remained along the greater curvature. Until 20 weeks, the left colic flexure was fixed to the pancreatic tail, and near the flexure the mesocolon also fused with the renal fascia. The left splenic end of the greater omentum was folded and fused together to form a thick ligament‐like structure, i.e., the gastrocolic ligament. In addition, near the duodenojejunal junction, a peritoneal bridge was often seen containing the inferior mesenteric artery or vein. Although surgeons generally believe that the mesocolon can be gently detached from the greater omentum, the fusion plane in adults appears to be the result of secondary modification and simplification by vascular development. Clin. Anat. 22:716–729, 2009. © 2009 Wiley‐Liss, Inc.
ChemInform Abstract: The Chemical Stability and Conductivity of BaCe0.9‐xYxSn0.1O3‐ δ Solid Proton Conductor for SOFC.
Authors: Xie Kui , Yan Ruiqiang , Liu Xingqin
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis, Structure and Charge Transport Properties of Yb5Al2Sb6: A Zintl Phase with Incomplete Electron Transfer.
Authors: Todorov Iliya , Chung Duck Young , Ye Linhui , Freeman Arthur J. , Kanatzidis Mercouri G.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Catalytic atropo‐Enantioselective Preparation of Axially Chiral Biaryl Compounds.
Authors: Ashizawa Tomoko , Yamada Tohru
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Convenient Synthesis of Chlorohydrins from Epoxides Using Zinc Oxide: Application to 5,6‐Epoxysitosterol (X).
Authors: Moghaddam Firouz Matloubi , Saeidian Hamdollah , Mirjafary Zohreh , Javan Marjan Jebeli , Farimani Mehdi Moridi , Seirafi Marjan
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient and Chemoselective Acetalization of Carbonyl Compounds Catalyzed by New and Reusable Zirconyl Triflate, ZrO(OTf)2.
Authors: Moghadam Majid , Mohammadpoor‐Baltork Iraj , Tangestaninejad Shahram , Mirkhani Valiollah , Yazdani Parvin , Ghorjipoor Saeedeh
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Conjugate Addition of 1‐Bromonitroalkanes to α,β‐Unsaturated Aldehydes Catalyzed by Chiral Secondary Amines.
Authors: Zhang Jun‐min , Hu Zhi‐peng , Dong Li‐ting , Xuan Yi‐ning , Lou Chun‐Liang , Yan Ming
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iron‐Catalyzed Carbolithiation of Alkynes Having no Heteroatoms.
Authors: Shirakawa Eiji , Ikeda Daiji , Ozawa Tsubasa , Watanabe Shogo , Hayashi Tamio
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Highly α‐Regioselective In(OTf)3‐Catalyzed N‐Nucleophilic Substitution of Cyclic Baylis—Hillman Adducts with Aromatic Amines.
Authors: Liu Yu‐Liang , Liu Li , Wang Dong , Chen Yong‐Jun
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of Allylic Phosphoranes with Iron Porphyrin Carbenoids: Efficient, Selective, and Catalytic Intermolecular Formal Carbenoid Insertion into Olefinic C—H Bonds.
Authors: Wang Sunewang R. , Zhu Chun‐Yin , Sun Xiu‐Li , Tang Yong
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Desymmetrization of meso‐N‐Acylaziridines with Benzenethiols Promoted by α,α‐Diaryl‐L‐prolinols.
Authors: Lattanzi Alessandra , Della Sala Giorgio
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Complete Regio‐ and Stereoselectivity Control in the Halohydroxylation of Non‐Activated Allenes Mediated by a Remote Sulfinyl Group.
Authors: Garcia Ruano Jose Luis , Marcos Vanesa , Aleman Jose
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: New Chiral Schiff Bases Derived from (+)‐ and (‐)‐α‐Pinenes in the Metal Complex Catalyzed Asymmetric Oxidation of Sulfides.
Authors: Koneva E. A. , Volcho K. P. , Korchagina D. V. , Komarova N. I. , Kochnev A. I. , Salakhutdinov N. F. , Tolstikov A. G.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chiral Broensted Acid Catalyzed Enantioselective α‐Hydroxylation of β‐Dicarbonyl Compounds.
Authors: Lu Min , Zhu Di , Lu Yunpeng , Zeng Xiaofei , Tan Bin , Xu Zhenjiang , Zhong Guofu
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Regioselective Synthesis of Benz[a]anthracene Derivatives via a Pd‐Catalyzed Tandem C—H Activation/Biscyclization Reaction.
Authors: Ren Zhi‐Hui , Guan Zheng‐Hui , Liang Yong‐Min
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Simple and Efficient Oxidation Procedure for the Synthesis of Acid‐Sensitive Epoxides.
Authors: Bortolini Olga , Fantin Giancarlo , Fogagnolo Marco
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: One‐Pot [1 + 1 + 1] Synthesis of Dithieno[2,3‐b:3′,2′‐d]thiophene (DTT) and Their Functionalized Derivatives for Organic Thin‐Film Transistors.
Authors: Chen Ming‐Chou , et al. et al.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Direct Approach to Multi‐Substituted Pyrroles from 2‐Propynylamine and 1,3‐Diketone or β‐Keto Ester Using Bi(OTf)3 Catalyst.
Authors: Komeyama Kimihiro , Miyagi Motoyoshi , Takaki Ken
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formation of 1,2‐Dioxolanes Using Mn(III)‐Based Reaction of Various Arylacetylenes with 2,4‐Pentanedione and Related Reaction.
Authors: Tsubusaki Takuma , Nishino Hiroshi
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple and Quick Preparation of α‐Thiocyanate Ketones in Hydroalcoholic Media. Access to 5‐Aryl‐2‐imino‐1,3‐oxathiolanes.
Authors: Bisogno Fabricio R. , Cuetos Anibal , Lavandera Ivan , Gotor Vicente
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Synthesis of Some 2,4‐Thiazolidinedione Derivatives.
Authors: Mahalle Shital , Ligampalle Dinesh , Mane Ramrao
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Copper Nanoparticles in Click Chemistry: An Alternative Catalytic System for the Cycloaddition of Terminal Alkynes and Azides.
Authors: Alonso Francisco , Moglie Yanina , Radivoy Gabriel , Yus Miguel
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Evaluation of Benzophenone Oximes Derivatized with Sydnone as Inhibitors of Secretory Phospholipase A2 with Antiinflammatory Activity.
Authors: Kamble Ravindra Ramappa , Belgur Sudha Sathyanarayanrao , Aladkatti Ravindranath , Khazi Imthiyaz Ahmed
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Fully Substituted Pyrano[2,3‐c]pyrazole Derivatives via a Multicomponent Reaction of Isocyanides.
Authors: Shaabani Ahmad , Sarvary Afshin , Rezayan Ali Hossein , Keshipour Sajjad
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of Novel 3‐(Aryl)benzothieno[2,3‐c]pyran‐1‐ones from Sonogashira Products and Intramolecular Cyclization: Antitumoral Activity Evaluation.
Authors: Queiroz Maria‐Joao R. P. , Calhelha Ricardo C. , Vale‐Silva Luis A. , Pinto Eugenia , Nascimento M. Sao‐Jose
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Cyclization of 2′‐Aminochalcones Using Silica‐Supported Yb(OTf)3 under Solvent‐Free Conditions.
Authors: Li Jianjun , Jin Linyong , Yu Chuanming , Su Weike
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis of [1,2,4]Triazolo[1,5‐a]pyridines of Potential PGE2 Inhibitory Properties.
Authors: Girgis Adel S. , Barsoum Flora F.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Substituted Quinolinyl Chalcones and Quinolinyl Pyrimidines as a New Class of Antiinfective Agents.
Authors: Sharma Moni , Chaturvedi Vinita , Manju Y. K. , Bhatnagar Shalini , Srivastava Kumkum , Puri S. K. , Chauhan Prem M. S.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Organoiodine(III)‐Mediated Synthesis of 3‐Aryl/Heteroaryl‐5,7‐dimethyl‐1,2,4‐triazolo[4,3‐c]pyrimidines as Antibacterial Agents.
Authors: Kumar Ravi , Nair Reshmi R. , Dhiman Saurabh Sudha , Sharma Jitender , Prakash Om
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Benzothiazines in Synthesis. Eight‐Membered Ring Formation in an Intramolecular Friedel—Crafts Reaction.
Authors: Harmata Michael , Ying Weijiang , Barnes Charles L.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Reaction of 2‐Chloro‐4,5‐dihydroimidazole with 1‐Aminobenzimidazoles: Synthesis of Novel Fused Heterocyclic Ring System (III).
Authors: Kornicka A. , Bednarski P. J.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Synthesis and Functionalization of Selenolopyrimidines.
Authors: Hesse Stephanie , Chenet Celia , Thomae David , Kirsch Gilbert
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The First Total Synthesis of Galloyl Tyramine.
Authors: Ullah Nisar
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Photoinduced Cross‐Linking Reactions of 4,5′‐8‐Trimethylpsoralen‐incorporated Oligodeoxyribonucleotide.
Authors: Kobori Akio , Takaya Kazutaka , Higuchi Maiko , Yamayoshi Asako , Murakami Akira
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Magnetic Phases of Bismuth Ferrite
Authors: Scott J. F.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Silicon, Germanium, Tin and Lead
Authors: Layfield Richard A.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Scandium, Yttrium and the Lanthanides
Authors: Brennan John G. , Sella Andrea
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Recent Advances in the Chemistry, Biosynthesis and Pharmacology of Rapamycin Analogues
Authors: Graziani Edmund I.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Rhodium‐Catalyzed Tandem Transformations with Organoboron Reagents: Sequential Multiple C—C Bond Formations.
Authors: Youn So Won
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Why Are Ionic Liquids Attractive for CO2 Absorption? An Overview
Authors: Huang Junhua , Ruether Thomas
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Chemical Glycobiology of Glycosphingolipids
Authors: Xia Chengfeng , Zhang Yalong , Zhang Wenpeng , Chen Wenlan , Song Jing , Yao Qingjia , Liu Yang , Zhou Dapeng , De Libero Gennaro , Wang Peng George
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Uracil as a Target for Nucleophilic and Electrophilic Reagents
Authors: Boncel Slawomir , Gondela Andrzej , Walczak Krzysztof
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Arthropod Alkaloids in Poison Frogs: A Review of the “Dietary Hypothesis”.
Authors: Saporita Ralph A. , Spande Thomas F. , Garraffo H. Martin , Donnelly Maureen A.
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Separation of Nanocarbons by Molecular Recognition
Authors: Komatsu Naoki
Published: July 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
Mit ArgusLab Chromophore betrachten
Authors: Peichert Rasmus
Published: July 2009

Kann man sich eine Abiturprüfung oder eine Lehramtsprüfung im Fach Chemie vorstellen, bei der das Thema Farbstoffe nicht mehr vorkommen darf, weil es aus dem SII‐Kanon gestrichen wurde? Wohl kaum, hieße das doch, unseren Schülern hätte man eine der ergiebigsten Quellen für den Erwerb anwendbaren Wissens, für neue, interessante Erkenntnisse und schließlich auch für Freude an unserem Fach verschlossen.

Den Vorwurf, das Thema Farbstoffe sei schwierig und würde oft zu theorielastig behandelt, sollte man ernst nehmen und sich um eine weitestgehende Vereinfachung bemühen. Dennoch steht fest: Um ein Minimum von Fachbegriffen kommt man nicht herum. Darüber allerdings, welche das sein sollten, gehen die Lehrmeinungen noch immer auseinander und die Diskussion verschiedener historisch gewachsener Konzepte hält an. Neuerdings lässt sich nun eine Entscheidung pro und kontra durch ein jedermann zugängliches Medium untermauern, das „molecular modeling”︁. Wie es mit dem Programm ArgusLab möglich ist, die Lichtabsorption eines konjugierten Systems zu erläutern, ohne auf MO‐theoretische oder mathematische Hintergründe näher einzugehen, will der folgende Beitrag zeigen.
Das an Schülervorstellungen orientierte Unterrichtsverfahren: Beispiel Neutralisation
Authors: Dörfler Tobias , Barke Hans‐Dieter
Published: July 2009

Petermann, Friedrich und Oetken stellten vor kurzem „Das an Schülervorstellungen orientierte Unterrichtsverfahren”︁ vor ([1], für frühere Aufsätze siehe auch [19, 20]]. Gemeinsam mit dem Arbeitskreis der PH Freiburg arbeitet der Arbeitskreis Barke der Universität Münster im „Kooperationsteam Schülervorstellungen”︁. Erklärte Aufgabe ist die konkrete Einbindung von empirisch erhobenen Schülervorstellungen in den naturwissenschaftlichen Unterricht. Die Freiburger widmen sich vermehrt den Präkonzepten, also jenen vorläufigen Vorstellungen, die Lernende in der Lebenswelt entwickeln und in den Unterricht mitbringen. Neben solchen Präkonzepten unterscheidet man in der fachdidaktischen Forschung „hausgemachte Fehlvorstellungen”︁, die nicht in den Unterricht mitgebracht werden, sondern erst dort entstehen [2]. So bringen Schüler im Allgemeinen nur oberflächliche Vorkenntnisse zur Thematik Säuren und Laugen mit in den Unterricht: den Lehrpersonen muss es deshalb vor allem um die Prävention hausgemachter Fehlvorstellungen zu dieser Problematik gehen. Dazu gehört eine reflektierte Unterrichtsplanung und Durchführung, die bei Kenntnis der bekannten Fehlvorstellungen eben diese Vorstellungen im Chemieunterricht erst gar nicht entstehen lassen. Diesbezüglich wurde eine Unterrichtssequenz zum Thema „Neutralisation”︁ entwickelt und evaluiert. Die Evaluation ergibt, dass Schüler den eingesetzten Fragebogen nach jedem Unterrichtsabschnitt erfolgreicher beantworten, insbesondere korrigieren sie erfolgreich die mitgeteilten, möglichen Fehlvorstellungen durch ihre im Unterricht neu erworbene wissenschaftliche Vorstellung.
Risk score for outcome after allogeneic hematopoietic stem cell transplantation
Authors: Gratwohl Alois , Stern Martin , Brand Ronald , Apperley Jane , Baldomero Helen , de Witte Theo , Dini Giorgio , Rocha Vanderson , Passweg Jakob , Sureda Anna , Tichelli André , Niederwieser Dietger ,   for the European Group for Blood and Marrow Transplantation and the European Leukemia Net
Published: July 2009

BACKGROUND:

It was investigated whether the European Group for Blood and Marrow Transplantation risk score, previously established for chronic myeloid leukemia, could be used to predict outcome after allogeneic hematopoietic stem cell transplantation (HSCT) for hematological disease in general.

METHODS:

Age of patient, disease stage, time interval from diagnosis to transplant, donor type, and donor‐recipient sex combination were used to establish a score from 0 to 7 points. Its validity was tested in 56,505 patients, 33,113 (58%) male, 23,392 female, median age 33 years (range, 0.5‐77 years), with an allogeneic HSCT for a hematological disorder between 1980 and 2005.

RESULTS:

Survival probability at 5 years decreased from 71% (95% confidence interval [CI], 69%‐73%) for risk score 0 for the whole cohort (75%, 95% CI, 72%‐78% for the most recent time cohort) to 24% (95% CI, 21%‐27% for risk score 6 and 7; 25%, 95% CI, 22%‐29% most recent cohort). Transplant‐related mortality increased from 15% (95% CI, 14%‐17%) for risk score 0 (11%, 95% CI, 9%‐13%, most recent cohort) to 47% with risk score 6 and 7 (95% CI, 44%‐50%) for the whole cohort (45%, 95% CI, 42%‐48%, most recent cohort). The risk score was predictive in all disease categories, over all time periods, and was not altered by transplant techniques.

CONCLUSIONS:

Five well‐defined pretransplant patient and donor characteristics give a reasonable risk estimate of allogeneic HSCT. This risk score can provide a basis for the decision between transplant and nontransplant strategies. Cancer 2009. © 2009 American Cancer Society.
Adenosine diphosphate‐ribosylation factor 6 is required for epidermal growth factor‐induced glioblastoma cell proliferation
Authors: Li Ming , Wang Jide , Ng Samuel S. M. , Chan Chu‐yan , He Ming‐liang , Yu Fang , Lai Lihui , Shi Chao , Chen Yangchao , Yew David T. , Kung Hsiang‐fu , Lin Marie Chia‐mi
Published: July 2009

BACKGROUND:

Epidermal growth factor (EGF) signaling plays a pivotal role in gliomagenesis. The authors previously demonstrated that adenosine diphospate‐ribosylation factor 6 (ARF6), a member of the Ras‐related small guanosine‐5′‐triphospate‐binding protein family, is required for EFA6A‐induced glioma cell migration and invasion. However, the role of ARF6 in EGF signaling is unknown.

METHODS:

The authors analyzed messenger RNA (mRNA) levels of ARF6 and EGF receptor (EGFR) in 16 high‐grade glioma samples and in 6 low‐grade glioma samples by reverse transcriptase‐polymerase chain reaction analysis. To determine whether EGF induces ARF6 expression in human glioblastoma U87 cells through transcriptional regulation and EGFR activation, the levels of ARF6 were assayed in EGF‐treated U87 cells that were preincubated with a transcriptional inhibitor (actinomycin D) and an EGFR tyrosine kinase inhibitor (PD153035), respectively. The downstream signaling of EGFR‐mediated ARF6 up‐regulation also was investigated using specific inhibitors of mitogen‐activated protein kinase (MEK), phosphatidylinositol 3′ kinase (PI3K), and Janus kinase 2. The involvement of SP1 in the downstream signaling was studied by using an SP1 inhibitor (mithramycin A). Small‐interfering RNAs (siRNAs) targeting ARF6 were used to investigate the effects of ARF6 on EGF‐mediated glioma cell proliferation.

RESULTS:

The results demonstrated that ARF6 and EGFR mRNA levels were elevated in glioma tissues. Furthermore, EGF stimulated ARF6 expression in U87 cells in a dose‐dependent and time‐dependant manner. This stimulation was caused by increased transcription of ARF6 and by activation of the MEK/extracellular signal‐regulated kinase 1 and 2 (ERK1/2) and PI3K signaling pathways. It is noteworthy that SP1 was essential for EGF‐induced ARF6 up‐regulation. Finally, EGF‐induced glioblastoma cell proliferation depended on ARF6, because the suppression of ARF6 by siRNA or by a dominant‐negative mutant significantly inhibited EGF‐induced cell proliferation.

CONCLUSIONS:

The results of the current study suggested that EGF‐induced ARF6 expression plays a significant role in glioma cell proliferation. Cancer 2009. © 2009 American Cancer Society.
Emotion‐focused therapy in a case of anorexia nervosa
Authors: Dolhanty Joanne , Greenberg Leslie S.
Published: July 2009

An emotion‐focused approach to the treatment of eating disorders and to case formulation is described in an individual with anorexia nervosa (AN). The basic theory of emotion‐focused therapy (EFT), the steps of case formulation and an outline of the tasks and course of treatment of an individual recently hospitalized on an inpatient unit for eating disorders highlight key aspects of the approach. The transformation in this individual, in terms of gaining access to her internal experience, understanding and tolerating her emotions, and working through her core themes of insecure attachment and worthlessness, is described. Weight and scores on self‐report measures at the outset of treatment and at 18 months are provided. Copyright © 2009 John Wiley & Sons, Ltd.

Key Practitioner Message:

Guidelines for treating eating disorders are tenuous and new approaches showing promise must be developed.

Emotion‐focused therapy (EFT) shows promise in the treatment of eating disorders.

Description of the case shows the application of EFT to anorexia nervosa and illustrates the change in the individual in terms of recognizing and coping with emotional experience.