bluuebunny/crossref_metadata_2025 huggingface dataset:
Sodium content of restaurant dishes in China: a cross-sectional survey
Authors: Du Wenwen , Wang Huijun , Zhang Jiguo , Zhang Xiaofan , Wei Nan , Li Yuan , Tan Monique , Zhang Puhong , He Feng J.
Published: February 2022

Background

Sodium intake in China is extremely high and eating in restaurants is increasingly popular. Little research has explored the sodium level of restaurant dishes. The present study aims to assess the content and sources of sodium in Chinese restaurants.

Methods

Cross-sectional data were obtained from the baseline survey of the Restaurant-based Intervention Study (RIS) in 2019. A total of 8131 best-selling restaurant dishes with detailed recipes from 192 restaurants in China were included. Sodium content per 100 g and per serving were calculated according to the Chinese Food Composition Table. The proportion of restaurant dishes exceeding the daily sodium reference intake level in a single serving and the major sources of sodium were determined.

Results

Median sodium content in restaurant dishes were 487.3 mg per 100 g, 3.4 mg per kcal, and 2543.7 mg per serving. For a single serving, 74.9% of the dishes exceeded the Chinese adults’ daily adequate intake for sodium (AI, 1500 mg per day), and 62.6% of dishes exceeded the proposed intake for preventing non-communicable chronic diseases (PI, 2000 mg per day). Cooking salt was the leading source of sodium in Chinese restaurant dishes (45.8%), followed by monosodium glutamate (17.5%), food ingredients (17.1%), soy sauce (9.4%), and other condiments/seasonings (10.2%). More types of salted condiments/seasonings use were related to higher sodium level.

Conclusions

The sodium levels in Chinese restaurant dishes are extremely high and variable. In addition to cooking salt, other salted condiments/seasonings also contribute a large proportion of sodium. Coordinated sodium reduction initiatives targeting the main sources of sodium in restaurant dishes are urgently needed.
Cocktail strategy based on a dual function nanoparticle and immune activator for effective tumor suppressive
Authors: Li Qian , Chen Qiubing , Yang Xue , Zhang Yuelan , Lv Linyue , Zhang Zhuyou , Zeng Shaowei , Lv Jiaxi , Liu Sijin , Fu Bishi
Published: February 2022

Background

Immune checkpoint inhibitor-mediated immunotherapy cannot be carried out on a large scale clinically due to its low universality. In recent years, cyclic guanosine monophosphate synthase/interferon gene stimulating factor (cGAS/STING)-mediated innate immune signaling pathway-mediated immunotherapy has attracted more and more attention. In addition, metabolic inhibitors also show good effects on tumor treatment, but their application is often limited because of their large first pass effect or difficult administration.

Methods

The particle size and potential parameters were measured by DLS. In order to determine the optimal ratio of the two drugs, we calculated the CI value of different nanoparticles through MTT experiment, and simulated their synergistic effect through Gaussian software. Then the morphology and crystal form of the best proportion of drugs were studied by TEM and XRD. The anti-tumor mechanism of composite nanoparticles was confirmed by the determination of metabolic related indexes, Q-PCR and WB. The antitumor effect and immune activation effect were comprehensively evaluated by in vivo and in vitro experiments.

Results

Here, we found and synthesized BCP nanoparticles ((BPA + CPI) @ PLGA NPs) which can effectively reduce the metabolism of tumor cells and inhibit cell proliferation. At the same time, the release of mitochondrial DNA (mtDNA) caused by mitochondrial metabolism disorder further activated the cGAS/STING signal pathway in Hepa1–6 cells. We found that the drug-treated Hepa1–6 cells had obvious TBK1 phosphorylation and STING dimerization. Combined with STING agonist, it could effectively promote the activation of CD8 T cells and enhanced the therapeutic effect on liver cancer.

Conclusion

Our results showed that PLGA nanocarrier can successfully improve the dosage forms of two metabolic inhibitors and show the effect of synergistic therapy. BCP nanoparticles can also activate the innate immunity of tumor cells and significantly enhance tumor inhibition after combined with STING agonists. This study has high reference and transformation value for the combined treatment of immunosuppression and metabolic inhibition.

Graphical Abstract
Measurement properties and responsiveness of the EQ-5D-Y-5L compared to the EQ-5D-Y-3L in children and adolescents receiving acute orthopaedic care
Authors: Verstraete Janine , Marthinus Zara , Dix-Peek Stewart , Scott Des
Published: February 2022

Objective

The aim of this study is a head-to-head comparison of the instrument performance and responsiveness of the EQ-5D-Y-3L and the expanded English version of the EQ-5D-Y-5L in children/adolescents receiving acute orthopaedic management in South Africa.

Methods

Children/adolescents aged 8–15 years completed the EQ-5D-Y-5L, EQ-5D-Y-3L, self-rated health (SRH) question and PedsQL at baseline. The EQ-5D-Y-5L, EQ-5D-Y-3L and SRH question were repeated after 24 and 48 h. Performance of the EQ-5D-Y-5L and EQ-5D-Y-3L was determined by comparing feasibility (missing responses), redistribution of dimensions responses, discriminatory power, concurrent validity, and responsiveness.

Results

Eighty-three children/adolescents completed baseline measures and seventy-one at all three time-points. Reporting of 11111 decreased by 20% from the EQ-5D-Y-3L to the EQ-5D-Y-5L. Informativity of dimensions improved on average by 0.267 on the EQ-5D-Y-5L with similar evenness. There was a range of 11–27% inconsistent responses when moving from the EQ-5D-Y-3L to the EQ-5D-Y-5L. There was a low to moderate and significant association on the EQ-5D-Y-3L and EQ-5D-Y-5L to similar items on the PedsQL and SRH scores. Percentage change over time was greater for the EQ-5D-Y-5L (range 0–182%) than EQ-5D-Y-3L (range 0–100%) with the largest reduction for both measures between 0 and 48 h. For those who respondents who showed an improved SRH the EQ-5D-Y-5L and EQ-5D-Y-3L showed significant paired differences.

Conclusion

The English version of the EQ-5D-Y-5L appears to be a valid and responsive extension of the EQ-5D-Y-3L for children receiving acute orthopaedic management. The expanded levels notably reduce the ceiling effect and has greater discriminatory power. Concurrent validity of the EQ-5D-Y-3L and EQ-5D-Y-5L was low to moderate with similar PedsQL items and SRH. The EQ-5D-Y-5L generally showed greater change than the EQ-5D-Y-3L across all dimensions with the greatest change observed for 0–48 h. Responsiveness was comparable across the EQ-5D-Y-3L and EQ-5D-Y-5L for those with improved SRH. Greater sensitivity to change may be observed on comparison of utility scores, once preference-based value sets are available for the EQ-5D-Y-5L.
Opportunities and challenges of patient-derived models in cancer research: patient-derived xenografts, patient-derived organoid and patient-derived cells
Authors: Hou Xiaoying , Du Cong , Lu Ligong , Yuan Shengtao , Zhan Meixiao , You Pengtao , Du Hongzhi
Published: February 2022

Background

As reported, preclinical animal models differ greatly from the human body. The evaluation model may be the colossal obstacle for scientific research and anticancer drug development. Therefore, it is essential to propose efficient evaluation systems similar to clinical practice for cancer research.

Main body

While it has emerged for decades, the development of patient-derived xenografts, patient-derived organoid and patient-derived cell used to be limited. As the requirements for anticancer drug evaluation increases, patient-derived models developed rapidly recently, which is widely applied in basic research, drug development, and clinical application and achieved remarkable progress. However, there still lack systematic comparison and summarize reports for patient-derived models. In the current review, the development, applications, strengths, and challenges of patient-derived models in cancer research were characterized.

Conclusion

Patient-derived models are an indispensable approach for cancer research and human health.
Differences in tumor-infiltrating lymphocyte density and prognostic factors for breast cancer by patient age
Authors: Takada Koji , Kashiwagi Shinichiro , Asano Yuka , Goto Wataru , Morisaki Tamami , Shibutani Masatsune , Tanaka Hiroaki , Hirakawa Kosei , Ohira Masaichi
Published: February 2022

Background

Lymphocytes that surround cancer participate in tumor-related immune responses and are called tumor-infiltrating lymphocytes (TILs). Several recent reports suggest TILs index the tumor microenvironment and predict the therapeutic effect of chemotherapy. However, only few studies have studied the relationship between age and TILs. Aging reduces host immunity, and we predict that it may also affect TILs. Thus, we hypothesized that older breast cancer (BC) patients may have low TIL density than younger BC patients. Here, we retrospectively analyzed the differences in TILs by age and the therapeutic effects of preoperative chemotherapy (POC) in BC patients who were aged either less than 45 years or more than 60 years.

Methods

We retrospectively examined the data of 356 breast cancer patients who underwent POC, including 75 patients aged ≤ 45 years and 116 patients aged > 60 years. Using pre-treatment needle biopsy specimens, TIL density was compared for each age group by Student’st-test. After analyzing different factors that affect TIL density, prognostic factors were also examined.

Results

Older patients with triple-negative BC had significantly lower TIL density than younger patients, while in human epidermal growth factor receptor 2 (HER2)-enriched BC, TIL density was significantly higher in the younger age group than that in the older age group. In addition, younger patients with HER2-rich breast cancer showed significantly higher complete pathological response rates than older patients with HER2-rich BC. In addition, significant differences in overall survival were observed among these patients with triple-negative BC.

Conclusions

Our study suggests that younger BC patients possess significantly higher TIL density than older patients. These differences may influence the therapeutic efficacy in highly immunogenic subtypes.
The neuroprotective mechanism of sevoflurane in rats with traumatic brain injury via FGF2
Authors: Wang Zhongyu , Wang Zhaoyang , Wang Anqi , Li Juan , Wang Junmin , Yuan Jingjing , Wei Xin , Xing Fei , Zhang Wei , Xing Na
Published: February 2022

Background

Traumatic brain injury (TBI) is a kind of acquired brain injury, which is caused by external mechanical forces. Moreover, the neuroprotective role of sevoflurane (Sevo) has been identified in TBI. Therefore, this research was conducted to figure out the mechanism of Sevo in TBI via FGF2.

Methods

The key factors of neuroprotective effects of Sevo in TBI rats were predicted by bioinformatics analysis. A TBI model was induced on rats that then inhaled Sevo for 1 h and grouped via lentivirus injection. Modified Neurological Severity Score was adopted to evaluate neuronal damage in rats, followed by motor function and brain water content measurement. FGF2, EZH2, and HES1 expression in brain tissues was evaluated by immunofluorescence staining, and expression of related genes and autophagy factors by RT-qPCR and Western blot analysis. Methylation-specific PCR was performed to assess HES1 promoter methylation level, and ChIP assay to detect the enrichment of EZH2 in the HES1 promoter. Neuronal damage was assessed by cell immunofluorescence staining, and neuronal apoptosis by Nissl staining, TUNEL staining, and flow cytometry.

Results

Sevo diminished brain edema, improved neurological scores, and decreased neuronal apoptosis and autophagy in TBI rats. Sevo preconditioning could upregulate FGF2 that elevated EZH2 expression, and EZH2 bound to the HES1 promoter to downregulate HES1 in TBI rats. Also, FGF2 or EZH2 overexpression or HES silencing decreased brain edema, neurological deficits, and neuronal autophagy and apoptosis in Sevo-treated TBI rats.

Conclusions

Our results provided a novel insight to the neuroprotective mechanism of Sevo in TBI rats by downregulating HES1 via FGF2/EZH2 axis activation.
The STAT6 inhibitor AS1517499 reduces the risk of asthma in mice with 2,4-dinitrochlorobenzene-induced atopic dermatitis by blocking the STAT6 signaling pathway
Authors: Li Xueying , Han Zhaoqing , Wang Feng , Qiao Jianou
Published: February 2022

Background

Epidemiological studies have revealed a link between atopic dermatitis (AD) and asthma. AS1517499, a selective signal transducer and activation of transcription 6 (STAT6) inhibitor, has been shown to effectively block this connection. In this study, we further explored the underlying mechanism by constructing an AD mouse model.

Methods

Female BALB/c mice were randomly divided into four groups (n = 10/group). The AD mouse model was established by 2,4-dinitrochlorobenzene induction with repeated ovalbumin challenge. AS1517499 and corn oil were used as treatment interventions. The features of airway inflammation, remodeling, and hyperactivity were analyzed.

Results

Active use of AS1517499 in AD mice effectively reduced Th2-related cytokine levels, alleviated airway eosinophil and lymphocyte infiltration, and regulated GATA3/Foxp3 levels and subepithelial collagen deposition. These changes might be due to specific blockade of the STAT6 signaling pathway.

Conclusion

AS1517499 could partially block the association between AD and asthma by specifically inhibiting the STAT6 signaling pathway.
Observation on dromedary (Camelus dromedarius) welfare and husbandry practices among nomadic pastoralists
Authors: Dioli Maurizio
Published: February 2022

Animal welfare is an important topic for consideration within every livestock husbandry sector. Welfare frameworks have recently been developed for intensively and semi-intensively husbanded dromedaries. These do not fit the reality of dromedaries under pastoral husbandry, and no specific analysis exists on dromedary welfare when reared under pastoral nomadic conditions. This article examines the existing husbandry practices utilised by nomadic pastoralists with the aim of improving the understanding of dromedary welfare in a nomadic pastoral husbandry system.
The global environmental agenda urgently needs a semantic web of knowledge
Authors: Balbi Stefano , Bagstad Kenneth J. , Magrach Ainhoa , Sanz Maria Jose , Aguilar-Amuchastegui Naikoa , Giupponi Carlo , Villa Ferdinando
Published: February 2022

Progress in key social-ecological challenges of the global environmental agenda (e.g., climate change, biodiversity conservation, Sustainable Development Goals) is hampered by a lack of integration and synthesis of existing scientific evidence. Facing a fast-increasing volume of data, information remains compartmentalized to pre-defined scales and fields, rarely building its way up to collective knowledge. Today's distributed corpus of human intelligence, including the scientific publication system, cannot be exploited with the efficiency needed to meet current evidence synthesis challenges; computer-based intelligence could assist this task. Artificial Intelligence (AI)-based approaches underlain by semantics and machine reasoning offer a constructive way forward, but depend on greater understanding of these technologies by the science and policy communities and coordination of their use. By labelling web-based scientific information to become readable by both humans and computers, machines can search, organize, reuse, combine and synthesize information quickly and in novel ways. Modern open science infrastructure—i.e., public data and model repositories—is a useful starting point, but without shared semantics and common standards for machine actionable data and models, our collective ability to build, grow, and share a collective knowledge base will remain limited. The application of semantic and machine reasoning technologies by a broad community of scientists and decision makers will favour open synthesis to contribute and reuse knowledge and apply it toward decision making.
Effectiveness and sustainability of the WHO multimodal hand hygiene improvement strategy in the University Hospital Bouaké, Republic of Côte d'Ivoire in the context of the COVID-19 pandemic
Authors: Müller Sophie Alice , N’Guessan Micheline , Wood Rebekah , Landsmann Lena , Rocha Carlos , Kouame Bléoué Jean , Djadji Dominique , Abrokwa Seth Kofi , Eckmanns Tim , Arvand Mardjan , Diané Bamourou , Borchert Matthias
Published: February 2022

Introduction

The most frequent adverse events in healthcare are healthcare-associated infections, whose burden is highest in resource-limited settings. In addition, low resource settings often lack Hand Hygiene (HH) knowledge and reliable supply to disinfectant, a necessity emphasized by the past West African Ebola Epidemic and the ongoing COVID-19 pandemic. PASQUALE aims to increase patient safety by introducing the WHO multimodal HH strategy in the University Hospital Bouaké, Côte d’Ivoire.

Methods

Assessment of HH knowledge, perception and compliance was performed 12 months before, right after the intervention and at a ten months interval using questionnaires for knowledge and perception and direct observation for compliance. The intervention consisted of a HH training and the introduction of local production of alcohol-based hand-rub. In the absence of a control group, the effectiveness of the intervention was assessed by a before-and-after study.

Results

Baseline knowledge score was 14/25, increased significantly to 17/25 (p < 0.001) upon first and decreased to 13/25 in second follow-up. Compliance showed a significant increase from 12.7% to 36.8% (p < 0.001) in first and remained at 36.4% in second follow-up. Alcohol-based hand-rub production and consumption almost doubled after first confirmed COVID-19 case in Côte d’Ivoire.

Conclusion

The WHO HH improvement strategy is an effective and pandemic-adaptable method to increase long-term HH compliance. This study emphasizes that the implementation of the strategy to build a robust system is of utmost importance.
Genetic, clinical, and biochemical aspects of patients with Alzheimer disease
Authors: El-Tallawy Hamdy Nageeb , Saadeldin Heba Mohamed , Ezzeldin Azza Mohamed , Tohamy Amal Mohamed , Eltellawy Sara , Bathalath Ali Mabrouk , Shehab Mohamed Mostafa
Published: February 2022

Background

The most common form of dementia is Alzheimer’s disease (AD). The clinical manifestations of AD are loss of memory that is progressive and deterioration in cognitive function. The objective of this study is to find patterns of AD among patients regarding clinical aspects, psychological aspects, and laboratory aspects, as well as to determine the role of some genes (APOE1, APOE2, and TMEM106B) in the pathogenesis of AD. In this case–control study, 40 patients with AD were recruited from the inpatient neurology departments and outpatient neurology clinics of the university hospitals in the period of January 1 to December 31, 2017. Furthermore, 40 cross-matched control patients underwent a complete history taking, neurological examination, brain MRI or CT, psychometric tests, thyroid function, and lipid profile measurements. Extracted DNA was quantified using a nanodrop analyzer (ND-1OOO) spectrophotometer for TMEM106B (rs1990622), APOE2 (rs429358), and APOE1 (rs7412).

Results

All subtypes of lipid profiles were significantly higher in patients with AD than the controls. There was a significant difference between the two groups regarding TMEM106B. There was an insignificant difference regarding thyroid hormones T3, T4, and TSH between patients and controls. There was no significant difference between AD patients and the control group regarding APOE-1 and APOE-2. Patients were worse than controls in tests of cognition, such as The Cognitive Abilities Screening Instrument (CASI) and auditory number and letter span test. In addition, AD patients had more depression than controls.

Conclusion

There may be a significant role of a high lipid profile and TMEM106B expression in the pathogenesis of AD.
Adherence to COVID-19 preventive measures among male medical students, Egypt
Authors: Ahmed Haytham Mahmoud
Published: February 2022

Background

Adherence to COVID-19 preventive measures is essential for disease control especially given the lack of effective treatment at the time of data collection. Medical students’ adherence to COVID-19 preventive measures is highly important because they are at a higher risk of infection as they spend considerable time at hospitals for training. In addition, they will be responsible for disease fighting in the future. This study aimed to identify the adherence to COVID-19 preventive measures among the studied male students of Al-Azhar Faculty of Medicine, Egypt.

Methods

An online survey was conducted on a convenience sample of 537 male medical students of Al-Azhar University at the Cairo branch between March 2 and April 15, 2021, using an Arabic questionnaire constructed by Google form with link sharing to students’ groups on WhatsApp and face book applications.

Results

A total of 537 students voluntarily submitted their responses. Most of these students were aged between 18 and 20 years (62.4%), rural residents (62.9%), having family income of 5000 LE or less/month (64.2%), studying at the first, second, and sixth years (79.2%). The prevalence of adherence to COVID-19 preventive measures among studied students was 28.1% without significant difference in the students’ adherence status regarding age, residence, family income, studying year, or academic score. Wearing a face mask outside the house was practiced by 58% of students, avoiding hugging or kissing others (41.3%), and keeping a distance from others (20.7%).

Conclusion

Students showed a low level of adherence to COVID-19 preventive measures among students. Also, there is no significant difference between students’ adherence status in relation to their socio-economic or academic variables. This unhealthy behavior increases the risk of infection among students. Also, students become a source of infection for their vulnerable contacts. More studies are needed to identify the real cause of this low level of adherence.
Diagnostic accuracy of endoscopic ultrasound in evaluation of patients with obstructive jaundice: single-center experience
Authors: Abou Bakr Shereen , Elessawy Hagar , Ghaly Sameh , Elezz Muhammed Abo , Farahat Ahmed , Zaghloul Mariam Salah
Published: February 2022

Background/aims

We prospectively evaluated the role of endoscopic ultrasound (EUS) in detecting the cause of common bile duct (CBD) dilatation in patients in whom trans-abdominal ultrasound (TUS) could not demonstrate the cause of dilation as a proper second step in the diagnostic workup of patients with obstructive jaundice compared to magnetic resonance cholangiopancreatography (MRCP).

Methods

This study was conducted on patients with obstructive jaundice admitted to the inpatient ward or the outpatient endoscopy unit of Theodor Bilharz Research Institute (TBRI) during the period between January 2019 and August 2019. A patient with obstructive jaundice and TUS showed CBD dilatation with internal diameter ≥ 7 mm and biliary stricture.

Results

During the period between January 2019 and August 2019, 136 were recruited; 8 patients who were pregnant and 3 patients who had gastric bypass surgery were excluded. Sixty-five patients were diagnosed confidently by TUS as biliary stones and were excluded from the analysis. Sixty patients with obstructive jaundice and indefinite etiology on TUS were included in the final analysis. The final diagnosis of patients was 38 patients (63.33%) of malignant etiology [26 pancreatic cancer (43.33%), 4 cholangiocarcinoma (6.66%), and 8 with ampullary cancer (13.33%)] and 22 patients (36.67%) of benign etiology [10 calcular obstruction (16.66%), 8 benign stricture (13.33%), and 4 pancreatitis (6.66%)]. The sensitivity and specificity values for malignant stricture detected by EUS were 100% and 86.36%, respectively, with positive predictive value of 92.68%, negative predictive value of 100%, and accuracy of 95%, while MRI showed 82.14% sensitivity and 25% specificity with positive predictive value of 79.31 and accuracy of 69.4%. EUS supported correct diagnosis in 57 patients (95%: CI 86.08 to 98.96%) while MRI did it in 36 patients (69.44%: CI 51.89% to 83.65%).Only 43 (71.7%) patients needed endoscopic retrograde cholangiopancreatography (ERCP) for management of obstructive jaundice, sparing 17 patients (28.3%) unnecessary invasive procedures.

Conclusions

EUS is a minimally invasive method with low incidence of complications with high diagnostic accuracy in patients with dilated CBD and normal MRCP.
Impact of COVID-19 on mental health research: is this the breaking point?
Authors: Sparasci Oli , Bhui Kamaldeep , Biswas Asit , Chamberlain Samuel , Dubicka Bernadka , Dudas Robert , Farooq Saeed , Ford Tamsin , Husain Nusrat , Jones Ian , Killaspy Helen , Lee William , Lingford-Hughes Anne , Mulholland Ciaran , Rubinsztein Judy , Shankar Rohit , Sharma Aditya , Sinclair Lindsey , Stone James , Young Allan
Published: February 2022

There are many structural problems facing the UK at present, from a weakened National Health Service to deeply ingrained inequality. These challenges extend through society to clinical practice and have an impact on current mental health research, which was in a perilous state even before the coronavirus pandemic hit. In this editorial, a group of psychiatric researchers who currently sit on the Academic Faculty of the Royal College of Psychiatrists and represent the breadth of research in mental health from across the UK discuss the challenges faced in academic mental health research. They reflect on the need for additional investment in the specialty and ask whether this is a turning point for the future of mental health research.
K-Ras and p53 mouse model with molecular characteristics of human rhabdomyosarcoma and translational applications
Authors: Nakahata Kengo , Simons Brian W. , Pozzo Enrico , Shuck Ryan , Kurenbekova Lyazat , Prudowsky Zachary , Dholakia Kshiti , Coarfa Cristian , Patel Tajhal D. , Donehower Lawrence A. , Yustein Jason T.
Published: February 2022

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children, with overall long-term survival rates of ∼65-70%. Thus, additional molecular insights and representative models are critical for identifying and evaluating new treatment modalities. Using MyoD-Cre-mediated introduction of mutant K-RasG12D and perturbations in p53, we developed a novel genetically engineered mouse model (GEMM) for RMS. The anatomic sites of primary RMS development recapitulated human disease, including tumors in the head, neck, extremities and abdomen. We confirmed RMS histology and diagnosis through Hematoxylin and Eosin staining, and positive immunohistochemical staining for desmin, myogenin, and phosphotungstic acid–Hematoxylin. Cell lines from GEMM tumors were established with the ability to engraft in immunocompetent mice with comparable histological and staining features as the primary tumors. Tail vein injection of cell lines had high metastatic potential to the lungs. Transcriptomic analyses of p53R172H/K-RasG12D GEMM-derived tumors showed evidence of high molecular homology with human RMS. Finally, pre-clinical use of these murine RMS lines showed similar therapeutic responsiveness to chemotherapy and targeted therapies as human RMS cell lines.
Cross-sectional assessment of cardiovascular risk factors in patients with knee osteoarthritis
Authors: Goel Sagar , Kamath Surendra Umesh , Annappa Rajendra , Krishnamurthy Sunil Lakshmipura , Jain Manesh , Thakkar Samarth , Damsas Lulu , Banerjee Sayak , Divakar Prajwal Madapura
Published: February 2022

Background:Osteoarthritis (OA) and cardiovascular disease (CVD) are prevalent in India. However, there is dearth of literature among Indians studying the relationship between the two. This study was carried out to assess various cardiovascular (CV) risk factors in patients with knee OA with an objective to investigate their association, screening and management. 

Methods: In total, 225 patients were included in this cross-sectional study. Participants were diagnosed with knee OA on the basis of the Kellgren and Lawrence (K-L) classification of their radiograph. Participants were also assessed for CV risk factors; age, body mass index, systolic blood pressure, diabetes mellitus, total cholesterol, high-density lipoprotein, smoking. Joint British Society QRisk3 calculator (JBS3) a comprehensive risk score calculator as well as a screening tool, which produces three more variables, namely 10-years risk of developing CVD, physiological heart age and life expectancy, was used. Chi Square, Fishers exact test and one-way ANOVA tests were used to compare the categorical and quantitative variables, respectively.. Multiple regression analysis was done to adjust the multiple con-founders and determine their significance.

Results: Patients with severe knee OA had a statistically significantly higher prevalence of CV risk factors (p<0.05). Grade 4 knee OA patients were found to have a mean JBS3 risk of 38%, heart age of 82 years and life expectancy of 77 years as compared to grade 2 patients who had a mean JBS3 risk of 11%, heart age of 63 years and life expectancy of 82 years. 

Conclusions: Our study concluded that there is a strong relation between knee OA and CVD, with CV risk score being positively correlated to the severity of OA.
Numerical model for enhancing stimulated Brillouin scattering in optical microfibers
Authors: Yeap Soon Heng , Emami Siamak Dawazdah , Abdul-Rashid Hairul Azhar
Published: February 2022

Stimulated Brillouin scattering (SBS) is useful, among others for generating slow light, sensing and amplification. SBS was previously viewed as a poor method due to the limitation on optical power in high-powered photonic applications. However, considering the many possible applications using SBS, it is now of interest to enhance SBS in areas of Brillouin frequency shift together with Brillouin Gain. A numerical model, using a fully vectorial approach, by employing the finite element method, was developed to investigate methods for enhancing SBS in optical fiber. This paper describes the method related to the numerical model and discusses the analysis between the interactions of longitudinal, shear and hybrid acoustic modes; and optical modes in optical fiber. Two case studies were used to demonstrate this. Based on this numerical model, we report the influence of core radius, clad radius and effective refractive index on the Brillouin frequency shift and gain. We observe the difference of Brillouin shift frequency between a normal silica optical fiber and that of a microfiber - a uniformed silica fiber of a much smaller core and cladding dimensions where nonlinearities are higher. Also observed, the different core radii used and their respective Brillouin shift. For future work, the COMSOL model can also be used for the following areas of research, including simulating “surface Brillouin shift” and also to provide in-sights to the Brillouin shift frequency vB of various structures of waveguides, e.g circular, and triangular, and also to examine specialty fibers, e.g. Thulium and Chalcogenide doped fibers, and their effects on Brillouin shift frequency.
Face off – a semiotic technology study of software for making deepfakes
Authors: Poulsen Søren Vigild
Published: February 2022

Deepfakes, an algorithm that transposes the face of one person onto the face of another person in images and film, is a digital technology that may fundamentally alter our belief in visual modality and thus presents alarming consequences for an image-centric culture. Not only are these face-translations now so advanced that it is virtually impossible for people to tell that they are fake – this technology is also becoming accessible to laypersons who, with little or no computer skills, can use them for all kinds of purposes, including criminal intentions like revenge porn and identity theft. It is therefore timely and crucial to explore the semiotic potential of deepfakes.

This paper presents a semiotic technology perspective, i.e., the study of technology for meaning- making that is an emergent field in social semiotics, to report on findings from an ongoing study of how deepfake software is designed and used as a semiotic resource in erotic and political contexts. The paper advances the argument that the software is able to appropriate all signifiers of the face and their cultural history. Consequently, the semiotic operations of this technology prepare the ground for the problematic perspectives of synthetic facial imagery.

On this basis, the paper calls for a critical awareness of taking visual representations of current events at face value and considers how deepfake technology is embedded in unsound sharing practices of visual artefacts that tamper with the rich meaning potential of the face.
Gotta face ‘em all: Pokémon, Japanese animated characters, and the emergence of playful visual animism
Authors: Idone Cassone Vincenzo
Published: February 2022

As a result of technological innovations and new cultural practices, the contemporary mediasphere is increasingly populated by digital(ized) faces. The phenomenon is not limited to human faces, but includes a vast universe of fictional animated faces, variously called ‘characters’, ‘mascots’ or ‘kyara’. In Japan, while certainly not new, kyara have been spreading thanks to globalization, digitalization and media-mix strategies. Through the connection between visual design, fictional narratives and socio-cultural consumption, kyara can be considered semiotic figures of in-betweenness, key symbolic mediators in the Japanese mediascape. Their anthropomorphic face design mediates the cultural boundaries between the human and the non-human, the animate and the inanimate, nature and culture. Furthermore, their post-modern narratives mix inspiration from the past and the present, from myths to science fiction. Lastly, they involve an encyclopedic reworking between fiction and reality, mythical references and secularization, between the domains of seriousness and playful make-believe. The article aims to explore the semiotic dimensions of kyara in contemporary Japan, with emphasis on their logic of representation and cultural outcomes. These will be investigated through the analysis of the Pokémon franchise, which will make it possible to describe the emergence of new semiotic patterns of ‘playful visual animism’ in the process of media facialization of everyday life.
Fatal portraits: The selfie as agent of radicalization
Authors: Mantello Peter
Published: February 2022

For the modern-day jihadist, the digital self-portrait or, more specifically, battlefield selfie is a popular tool for identity building. Similarly to the selfies taken by non-violent practitioners of self-capture culture, the jihadist selfie represents an alternative to the Cartesian formulation of a unitary and indivisible self. Rather, it is a product of social relations and performative actions, constituted in dialogue with others through very specific socio-cultural frameworks and expectations. However, unlike its non-violent Doppelgänger, the expectations of this dialogue are centred around a larger political agenda which actively seeks to reformat collective memories of imperial Islamic conquests and co-opt religion as a way to impose a moral order on its violence. Importantly, the battlefield selfie allows the jihadist easily to traverse the boundaries between two seemingly opposing belief systems. Although there exists a wealth of scholarship of self-capture culture, image sharing sites and micro-celebritism, their pervasive influence and practice on battlefield is understudied. This article draws from the personal histories of key Islamic extremists who were both lionized and demonized as a result of their battlefield micro-influencer practices. Today, however, the same individuals can achieve internet fame by participating in self-capture culture – posting selfies, videos or blogging. In other words, never before has a soldier’s public communication been so personal yet collective.
Jaan Kaplinski and his contacts with the Tartu-Moscow School of Semiotics
Authors: Velmezova Ekaterina , Kull Kalevi , Soovik Ene-Reet
Published: February 2022

Jaan Kaplinski (1941–2021), Estonian poet, essayist and public intellectual, sadly passed away earlier this year. To commemorate him, we publish some excerpts from a conversation with him that was recorded in 2018 and in which, among other topics, we also talked about Kaplinski’s relationship with semiotics and his personal contacts with eminent scholars of the Tartu-Moscow School.
Pan Tadeusz i Kresy: Studia językoznawcze
Authors: Szpiczakowska Monika
Published: February 2022

PAN TADEUSZ AND THE BORDERLANDS: LINGUISTIC STUDIES The book presents chosen articles of Monika Szpiczakowska, habilitated doctor and professor of the Jagiellonian University in the years 1993–2018. This material had been already published in scientific journals and collective volumes. It consists of two parts: From the past and present of the Polish language in the Northern Borderlands and About the language of Pan Tadeusz. Altogether, it contains fourteen texts.
Lemko Spatial Expressions in the System and in the Text
Authors: Fontański Henryk
Published: February 2022

Lemko Spatial Expressions in the System and in the TextThe study attempts to describe Lemko grammatical and syntactic linguistic means used to express spatial meanings: syntactems (elementary syntactic units) and types of sentences with the meaning of spatial relations and their use in texts.
Convex Maximization via Adjustable Robust Optimization
Authors: Selvi Aras , Ben-Tal Aharon , Brekelmans Ruud , den Hertog Dick
Published: February 2022

Maximizing a convex function over convex constraints is an NP-hard problem in general. We prove that such a problem can be reformulated as an adjustable robust optimization (ARO) problem in which each adjustable variable corresponds to a unique constraint of the original problem. We use ARO techniques to obtain approximate solutions to the convex maximization problem. In order to demonstrate the complete approximation scheme, we distinguish the cases in which we have just one nonlinear constraint and multiple linear constraints. Concerning the first case, we give three examples in which one can analytically eliminate the adjustable variable and approximately solve the resulting static robust optimization problem efficiently. More specifically, we show that the norm constrained log-sum-exp (geometric) maximization problem can be approximated by (convex) exponential cone optimization techniques. Concerning the second case of multiple linear constraints, the equivalent ARO problem can be represented as an adjustable robust linear optimization problem. Using linear decision rules then returns a safe approximation of the constraints. The resulting problem is a convex optimization problem, and solving this problem gives an upper bound on the global optimum value of the original problem. By using the optimal linear decision rule, we obtain a lower bound solution as well. We derive the approximation problems explicitly for quadratic maximization, geometric maximization, and sum-of-max-linear-terms maximization problems with multiple linear constraints. Numerical experiments show that, contrary to the state-of-the-art solvers, we can approximate large-scale problems swiftly with tight bounds. In several cases, we have equal upper and lower bounds, which concludes that we have global optimality guarantees in these cases.

Summary of Contribution: Maximizing a convex function over a convex set is a hard optimization problem. We reformulate this problem as an optimization problem under uncertainty, which allows us to transfer the hardness of this problem from its nonconvexity to the uncertainty of the new problem. The equivalent uncertain optimization problem can be relaxed tightly by using adjustable robust optimization techniques. In addition to building a new bridge between convex maximization and robust optimization, this approach also gives us strong algorithms that improve the state-of-the-art optimization solvers both in solution time and quality for various convex maximization problems.
Good Names Beget Favors: The Impact of Country Image on Trade Flows and Welfare
Authors: Chang Pao-Li , Fujii Tomoki , Jin Wei
Published: February 2022

This paper estimates the effects of time-varying consumer preference bias on trade flows and welfare. We use a unique data set from the BBC World Service Poll, which surveys (annually during 2005–2017 with some gaps) the populations of a wide array of countries on their views of whether an evaluated country is having a mainly positive or negative influence in the world. We identify the effects on consumer preference parameters due to shifts in these country image perceptions and quantify their general equilibrium effects on bilateral exports and welfare (each time for an evaluated exporting country, holding the exporting country’s own preference parameters constant). We consider five important shifts in country image: the George W. Bush effect, the Donald Trump effect, the Senkaku Islands Dispute effect, the Brexit effect, and the Good-Boy Canadian effect. We find that such changes in bilateral country image perceptions have quantitatively important trade and welfare effects. The negative impact of Donald Trump’s “America First” campaign rhetoric on the U.S.’s country image might have cost the United States 4%–5% of its total exports and welfare gains from trade. In contrast, the consistent improvement of Canada’s country image between 2010 and 2017 has amounted to more than 8% of its total welfare gains from trade.

This paper was accepted by Matthew Shum, marketing.
Pseudoaneurysm of a Bronchial Artery: An Unusual Cause of Chest Pain
Authors: Van Hove Pepijn , Jardinet Thomas
Published: February 2022

We report a case of a bronchial artery pseudoaneurysm presenting as acute retrosternal pain. We want to discuss and to announce the extremely rare finding of a bronchial artery pseudoaneurysm. Bronchial artery aneurysms and pseudoaneurysms are uncommon; however, missing this diagnosis is associated with significant morbidity and mortality. When suspecting this pathology urgent CT angiography and selective angiography (DSA) are crucial. Urgent treatment with transarterial embolization is preferred.
A Afirmação da Dignidade: Direitos Humanos e Paz como Valores Constituintes da Nova Ordem Mundial após 1945 | The Affirmation of Dignity: Human Rights and Peace as Constituent Values of the New World Order After 1945
Authors: Machado Gomes Daniel , Gavião Leandro
Published: February 2022

Este artigo visa analisar a relação entre as duas Grandes Guerras e a emergência dos direitos humanos e da paz como valores constituintes da nova ordem mundial forjada após 1945. Para entender a construção dos princípios que nortearam as sociedades na segunda metade do século XX, torna-se necessário retornar ao período da “Era da catástrofe” (1914-1945), observando de que modo o choque dos dois grandes conflitos foi traduzido em esforços para adequar Estados e cidadãos às novas normas de convivência estabelecidas, cujo epicentro ético alicerça-se na defesa dos direitos humanos e na valorização da paz.Palavras-chave: Direitos Humanos; Paz; Ordem Mundial.ABSTRACTThis article aims to analyze the relationship between the two World Wars and the emergence of human rights and peace as constituent values of the new world order forged after 1945. If necessary, return to the period of the “Age of catastrophe” (1914-1945), observing how the clash of the two great conflicts was translated into efforts to adapt States and citizens to the new established norms of coexistence, whose ethical epicenter is based on the defense of human rights and the promotion of peace.Keywords: Human Rights; Peace; World Order. Recebido em: 22/11/2021 | Aceito em: 29/01/2022.
ECG of the month
Authors: Bloe Charles
Published: February 2022

In this issue's ECG of the month, Charles Bloe presents the case of a 26-year-old woman with no relevant medical history who was experiencing intense chest pain and numbness of the left arm.
Recommendations for the optimal use of mesalazine in the management of patients with mild to moderate ulcerative colitis
Authors: Akbar Ayesha , Arnott Ian , Kennedy Nicholas A , Nolan Jonathan , Peake Simon , Whiteoak Simon R , Probert Chris , Fraser Aileen , Cheshire Alex , Lewis Allyson , Sugrue Kathleen , Laird Susan , Scott Glyn
Published: February 2022

The 2021 National report from IBD UK included responses from over 10 000 patients with inflammatory bowel disease, over 70% of whom reported having at least one flare in the last 12 months. As the first-line treatment for patients with mild and moderate ulcerative colitis, the action and delivery mechanisms of mesalazine are crucial for successful management of the disease. The choice of the most appropriate formulation of mesalazine and securing patient concordance and adherence to treatment remains a challenge for healthcare professionals. This article details the outcome of a roundtable discussion involving a group of gastroenterology consultants and specialist nurses which considered the importance of ensuring that patients have individualised mesalazine therapy before escalation to other treatments and gives recommendations for the management of patients with mild or moderate ulcerative colitis.
The challenges of nurse endoscopist training during the COVID-19 pandemic: trainee and trainer perspectives
Authors: Hamilton Conor , Mackle Oonagh , Donnelly Claire
Published: February 2022

Making the transition from band 5 nurse to band 7 nurse endoscopist can be quite stressful. This has been made more difficult because of reduced or cancelled endoscopy lists, as well as redeployment of trainee and qualified endoscopists to other areas, due to the COVID-19 pandemic. A 2020 multinational survey study by Pawlek et al, spanning 63 countries, reported a reduction of endoscopy volume by up to 93.8%, with colonoscopy being affected the most. Electronic resources have been employed to fill this gap in training, including video recording, simulation labs and increasing involvement in low-risk procedures; however, not every endoscopy unit is equipped with these facilities. Due to the reduced numbers of patients on endoscopy lists and lists being populated with only the most urgent cases, this introduces further challenges for trainee nurse endoscopists. Trainee nurse endoscopists have been adversely affected through the pandemic, by a lack of availability of hands-on training and practice. The targets to be met for qualification remain the same, while the time taken to reach those targets will more than likely be extended due to uncontrollable factors.