bluuebunny/crossref_metadata_2025 huggingface dataset:
Geo Statistical Tool for Soil Fertility Assessment in Pulses Growing Area of Melur Block, Madurai District, Tamil Nadu
Authors: Ramamoorthy P. , Mary P. Christy Nirmala , Saravanapandian P. , Gurusamy A. , Kumutha K.
Published: April 2022

Background: Soil fertility is a significant natural property which decides the health and quality of land resources. Pulse productivity diminishes nowadays under rain fed condition due to improper nutrient management practices. Hence the present study was carried out to assess the soil fertility status under major pulses growing area by using advanced geo statistical tool with ArcGIS. Methods: Soil survey was taken in 14 revenue villages in Melur block, Madurai district. Soil samples were collected and analysed for its nutrient properties. The Parker’s Nutrient Index and soil fertility maps were prepared by using ArcGIS. Result: Pulses growing soils were mostly neutral in pH and soluble salt content was low. The organic carbon and available nitrogen content was low to medium. The available phosphorus and potassium status were medium to high. Hence proper nutrient management practices are to be needed for augment pulse production in such area.
​​Evaluation of Cluster Bean [Cyamopsis tetragonoloba (L.) Taub] Genotypes for Drought Stress Adaptation and its Effects on Yield
Authors: Patel Samarth R. , Th Amarjeet Singh , Kumar Sushil , Fougat Ranbir S.
Published: April 2022

Background: Cluster bean is mostly grown in dry land arid zone areas for various purposes as vegetable, seed, fodder and other industrial uses because of its gum presence in endosperm. Methods: An experiment was conducted under the rain out shelter for the evaluation of drought adaptability of selected 10 genotypes of cluster bean. The physiological parameters were used to screen the drought resistance and also recorded various yield and yield attributing parameters at the time of harvesting. Result: Among the genotypes, Pusa Navbahar was observed well adaptability having adequate relative water content, maximum chlorophyll content, stomata per unit area and higher dry matter accumulation followed by genotype IC116866. Furthermore, yield and yield attributing parameters also showed significant differences; Pusa Navbahar was recorded maximum plant height (188.6 cm), leaves per plant (173.9), pods per plant (123.9), pod length (7.1 cm) and test weight (14.3 g) and well adaptability of primary and secondary root with deep in nature under the drought stress among the genotypes. Therefore, this study would be very helpful in the proper selection of genotypes as a source of drought resistance lines in future breeding and crop improvement programmes.
Peningkatan Pemahaman Mahasiswa Tentang Labeling Negatif melalui Bimbingan Kelompok Berbasis Al-Qur’an
Authors: Jannati Zhila
Published: April 2022

Negative labeling on children can have a negative impact on children. Children will feel isolated, sad, disappointed, and can even make negative behavior worse. The purpose of this study was to find out how to increase students' understanding of negative labeling through Al-Qur'an-based group guidance. The method used in this research is qualitative method. The data collection techniques are observation and interview techniques. The subjects of this study were 10 students of the Islamic Guidance and Extension Study Program, Raden Fatah State Islamic University Palembang. Data analysis in this study used descriptive qualitative data analysis. The results of this study are: (1) The implementation of Al-Qur'an-based group guidance through four stages, namely the formation stage, the transition stage, the activity stage (core), and the termination stage, and (2) Students' understanding of negative labeling has improved both in aspects of (a) an understanding of the meaning of negative labeling, (b) an understanding of the causes of negative labeling, (c) an understanding of the various types of labeling, (d) an understanding of the impact of negative labeling on individuals, and (e) an understanding of how to prevent negative labeling behavior towards others.
Keutamaan Bersedekah Sebagai Upaya Meningkatkan Kesehatan Mental
Authors: Jannati Zhila
Published: April 2022

Alms is one of the worship commanded by Allah swt. and recommended by the Messenger of Allah who by doing so humans will get a very beautiful reward from Him. The form of gratitude for all that Allah swt has given. Giving to humans can be realized by carrying out alms, both material and non-material alms. In addition, alms is one way that can be taken so that individuals can obtain a healthy mental. The purpose of this paper is to provide an understanding to each individual regarding the mental health of individuals in giving alms, with this understanding it is hoped that each individual will be happy and continue to give alms while Allah swt. breath to him on this earth. The results of this study are that in addition to obtaining rewards from Allah swt., alms can also make individuals mentally healthy where individuals can achieve happiness within themselves and can also create happiness for others. In addition, by giving charity, a person can achieve harmony of the functions of his soul, can create a sense of happiness and health, can avoid mental disorders, can face the challenges and trials of life well, can be positive with oneself and others and can accept what other people are
MENGAQIQAHKAN ORANG YANG SUDAH MENINGGAL MENURUT MADZHAB SYAFI’I DAN MADZHAB HANBALI
Authors: Gunawan Fauri , Purnomo Bitoh
Published: April 2022

Abstract
The  Law of Imparting People Who Have Died According to the Syafi'I School and the Hanbali School. According to the Shafi'i Madhhab, it is permissible to certify a person who has died, if there is a baby, it is sunnah to be aqiqah. If a parent dies, it is permissible if there is a will from the deceased person. Meanwhile, according to the Hanbali Madzhab, it is permissible to aqiqah a person who has died, be it a baby or an elderly person, as long as the aqiqah is performed in multiples of 7 (a week). And the similarities and differences between the Aqiqah of the Dead According to the Shafi'i and Hanbali schools, the similarities between the two are that they are both an expression of gratitude for the blessings that Allah has given in the form of the birth of a child. When a baby is born, Satan immediately meets him, embraces him, puts him in his hands and tries his best to make him his follower, while the difference between the two is in terms of the law. Meanwhile, in the Hanbali school of law, it is the sunnah of mu'akkad to aqiqah a person who has died. This research is a type of descriptive qualitative research, the method used in this thesis is library research
Keywords: Aqiqah, Madzhab Syafi‟i, Mazhab Hanbali
POLIGAMI DALAM KURUN WAKTU SATU HARI DITINJAU DARI UNDANG-UNDANG PERKAWINAN DAN HUKUM ISLAM
Authors: Wahyudi Amri
Published: April 2022

Abstract
In today's era the spread of information is very fast and wide, we can get information about events that occur in other parts of the world in Indonesia so quickly, this is the impact of advances in technology and information. Recently, we were shocked by the news about the marriage of a man with two women at the same time in Saling sub-district, Empat Lawang district, South Sumatra district. Judging from Law No. 1 of 1974 concerning marriage, of course polygamy in a period of less than one week is carried out, because there are conditions that polygamy must obtain permission from the Court, while the process to obtain such a permit would take a long time so it can be ascertained that polygamy that is carried out within one day cannot be done and if it is done then the polygamy is not recorded or illegal. Whereas in Islamic law polygamy can be done within one day and is valid with a record of the pillars and the conditions are met.
Keywords: Polygamy, Marriage, Islamic Law
Farklı Taşıyıcı Sistemlerin Gömülü Enerji ve Gömülü Karbon Değerlerinin Müstakil Konutlar Bağlamında Karşılaştırılması
Authors: Azkur Hatice Sena , Canan Fatih
Published: April 2022

Gömülü enerji, yapı malzemelerinin hammaddelerinin çıkarılması, üretimi, nakliyesi vb. süreçlerinde harcanan enerjinin toplamını ifade etmektedir. Gömülü karbon, malzemenin üretim süreci boyunca doğaya ne kadar sera gazı salındığının ölçüsüdür. Bu çalışmada yapının inşa öncesi evresine dikkat çekerek, bu süreçte tüketilen enerjinin ve doğaya yapılan karbon salınımının taşıyıcı sistemler bağlamında değerlendirilmesi amaçlanmıştır. Bu değerlendirme için gömülü karbon ve enerjiyi ölçen “Yaşam Döngüsü Değerlendirmesi (YDD)” yöntemi kullanılmıştır. Bu yöntem ile yapıda kullanılan malzemelerin gömülü karbon ve gömülü enerjileri sayısal veriler şeklinde elde edilebilmektedir. Konya’da ahşap müstakil bir konut alan çalışması için seçilmiş, bu yapının farklı taşıyıcı sistemlerle (betonarme ve çelik) alternatifleri üretilerek çevresel etkileri karşılaştırılmıştır. Ahşap yapı, bu üç yapım sistemi arasında en düşük karbon ve enerji değerlerini vermesi bakımından en çevre dostu alternatif olmuştur. Betonarme konut ve çelik konut sırasıyla onu izlemiştir. Hem düşük üretim enerjisi hem de düşük karbon salınımı avantajıyla müstakil konutlar bağlamında ahşap taşıyıcı sistemlerin en sürdürülebilir alternatif olduğu gözlemlenmiştir.
Şabazit Tipi Doğal Zeolit Kullanılarak Amonyak Gazının Uzaklaştırılması
Authors: Günal Aytaç , Erdoğan Burcu
Published: April 2022

Bu çalışmada, Bala'dan elde edilen şabazit (CHA) ve katyon (Na+, K+, Ca+2 ve Mg+2) değiştirilmiş ve hidroklorik asitle aktifleştirilmiş formları, ortamdan amonyak giderimindeki olası kullanılabilirliklerini göstermek amacıyla incelendi. Katyon değiştirilmiş ve asitle aktiflenmiş formlar sırasıyla, 1.0 M’lık KNO3, NaNO3, Mg(NO3)2, Ca(NO3)2 ve 0.1 M ve 1.0 M’lık HCl solüsyonları kullanılarak 90 oC'de 5 saat süreyle hazırlandı. Tüm numunelerin termal ve yapısal özellikleri TG-DTA, XRD ve XRF yöntemleri ile belirlendi. Şabazit numunelerinin BET yüzey alanları (231-448 m2 g-1), mikro gözenek yüzey alanları (216.2-421.3 m2 g-1) ve mikro gözenek hacimleri (0.086-0.169 cm3 g-1) 77 K'de elde edilen N2 adsorpsiyon izotermleri ile hesaplandı. Amonyak adsorpsiyon izotermleri 3Flex-Micromeritics cihazı ile 25 °C'de volumetrik olarak elde edildi. Şabazit numunelerinin amonyak adsorpsiyon kapasiteleri (5.699-8.931 mmol g-1), sırasıyla katyon değişimi ve asit aktivasyon işlemlerinin neden olduğu içeriksel ve yapısal değişiklikler açısından karşılaştırıldı.
Investigation of Photocatalytic Decolorization Parameters of Acid Violet 7 Dye With poly(ethylene glycol dimethacrylate-2-vinyl pyridine) -TiO2 Photocatalytic Polymer Microbeads
Authors: Yalçın Şeyma , Kara Ali
Published: April 2022

Poly(ethylene glycol dimethacrylate-2-vinyl pyridine)-TiO2 [poly (EGDMA-2-VP)] - TiO2 microbeads were synthesized by suspension polymerization method for photocatalytic decolorization of textile dyes from aqueous solution. The synthesized cross-linked [poly (EGDMA-2-VP)] - TiO2 microbeads were characterized by scanning electron microscopy (SEM), X-ray Diffraction (XRD) and fourier transform infrared spectroscopy (FTIR). To investigate the usability of the obtained microbeads in dye decolorization, the paramreters such as pH, polymer amount, time, and dye concentration were examined both under sunlight and 366 nm UV light. Optimum conditions under which maximum photocatalytic decolorization of the dye were pH 3, polymer amount 0.05 g, dye concentration 30 mg /L and time 5 hours.
ÖZEL GEREKSİNİMLİ ÇOCUĞU OLAN AİLELERİN GÖZÜNDEN KENT YOKSULLUĞU
Authors: KİZİR Mine , SEZER Sergender , HOŞGÖRÜR Tuğba , KAHYA Orhan , YILDIRIM Kasım , KORKUT Perihan , KARACA EVREN Mirace , YEŞİL Eda , HOSGORUR Vural
Published: April 2022

Bu çalışmanın amacı, özel gereksinimli (ÖG) çocuğu olan ailelerin deneyim ve görüşlerine dayanarak, kent yoksulluğunun profilini ortaya koymak ve deneyimledikleri yoksulluğun özel eğitime yansımalarını irdelemektir. Araştırma modeli olarak fenomenoloji deseni kullanılmıştır. Araştırmanın katılımcıları Muğla il merkezinde yaşayan ve özel gereksinimli çocuğu olan sekizi anne, dördü baba toplam 12 ebeveynden oluşan sekiz aile olmaktadır. Araştırmanın verileri yarı-yapılandırılmış görüşme tekniği ile toplanmıştır. Elde edilen veriler içerik analizi tekniğiyle analiz edilmiştir. Araştırma bulgularına göre, ÖG çocuğa sahip olan aileler olmayanlara göre, kent yoksulluğunu daha derinden hissetmektedirler. Aileler çocukları için sunulan özel eğitim hizmetlerini nitelik ve nicelik açısından yetersiz bulmakta ve yoksulluğun sonucu olarak çocuklarına ek özel eğitim hizmeti aldıramamaktadırlar. Ek olarak hem ÖG çocuğu olan bir aile olma hem de maddi yetersizliklerden dolayı kent hayatının sunduğu olanaklardan neredeyse hiç yararlanamamaktadırlar.
Rota Bioceânica Brasil-Paraguai-Argentina-Chile: desafios pela frente sob a ótica do Desenvolvimento Local
Authors: Asato Thiago Andrade , Dorsa Arlinda Cantero
Published: April 2022

A presente pesquisa explora os desafios futuros e já presentes de ordem social, ambiental e econômica sob a ótica do Desenvolvimento Local a partir da implantação da Rota Bioceânica, formada por Brasil, Paraguai, Argentina e Chile. O objetivo recai sobre a análise dos impactos e enfrentamentos em função da abertura de uma rota voltada para o desenvolvimento econômico produtivo (escoamento de grãos) e para o desenvolvimento turístico. A pesquisa realizou-se por meio de levantamento bibliográfico e documental. Os resultados revelam uma dependência política na viabilidade da rota em questão. Em caso de superação dos gargalos que envolvem a dinâmica da construção infraestrutural da rota, há um enorme potencial de integração comercial e turística, para os países do Corredor, ainda que não esteja clara qual atividade terá mais protagonismo, se a logística ou a turística.
Perfil dos usuários do Programa Melhor em Casa em um município do centro-oeste do Paraná
Authors: Castellani Lucivaldo José , Magni Cristiana
Published: April 2022

O Programa Melhor em Casa (PMC) é um dos dispositivos de atenção à saúde que visa proporcionar um tratamento humanizado aos usuários em domicílio, mediante a assistência contínua a pacientes com dificuldades ou impossibilidades de locomoção. Este estudo tem por objetivo apresentar o perfil dos usuários PMC em um município de médio porte do centro-oeste do Paraná. Realizou-se um estudo documental, exploratório-descritivo. A coleta de dados foi realizada entre os meses de abril e setembro de 2018. Os resultados apontaram que, no período pesquisado, a maioria dos usuários acompanhados apresentou idade igual ou superior a 60 anos; predomínio do atendimento a usuários do sexo feminino, com doenças crônicas, entre elas, as neoplasias. Como conclusão, percebeu-se que o conhecimento do perfil dos usuários é relevante para a elaboração de planos de ação e estratégias mais específicas à realidade local, visando à melhoria da assistência domiciliar no município.
Formação discente na graduação: um despertar para pesquisa e autoria
Authors: Barreto Marliton Rocha , Prata de Lima Dias Marieta
Published: April 2022

A educação superior é responsável em educar e servir à sociedade, e a orientação encontra-se entre as competências de uma instituição de ensino superior. Perante a obrigatoriedade para executar uma atividade de pesquisa ou extensão, o aluno depara-se com uma realidade − como a necessidade de ler e escrever − para a qual, muitas vezes, não tenha sido estimulado em etapas anteriores de sua educação formal. As atividades inerentes ao trabalho científico viabilizam situações de reflexão sobre o conhecimento acadêmico e sua ampliação em nível de pesquisa. Devido a tal constatação, em atividades de TCC e IC, tanto no Laboratório de Entomologia da Universidade Federal de Mato Grosso (UFMT) quanto em pesquisas interdisciplinares com Língua Portuguesa, os acadêmicos são convidados a exercitarem a habilidade de autoria e de criticidade diante de reflexões e do que se produz. Os acadêmicos aprendem a participar e valorizar eventos científicos e a retextualizar monografia para artigo científico.
Research on the impact of environmental information disclosure on foreign direct investment based on the “new normal” in China
Authors: Wu Chunxia , Wu Xianhua , Chen Xinze , Xu Xiaohui
Published: April 2022

In May 2014, China mentioned the concept of the “new normal” for the first time. The “new normal” economy promotes growth through development, replacing GDP growth with the all-round development of society and attaching greater importance to the sustainable development of society. China is a large recipient of foreign direct investment (FDI). Under the background of the “new normal”, it is worth exploring the impact of increased environmental supervision in China on FDI. This paper introduces the Pollution Information Transparency Index, which has been published in China since 2008, to quantify environmental information disclosure. The study also collects data about the Pollution Information Transparency Index and the FDI of all provinces and cities in China from 2014 to 2018. Finally, a regression analysis and a difference-in-difference model are constructed to analyze the impact of environmental information disclosure on FDI. The results show that, under the “new normal” economy, highly-disclosed environmental information has a significant impact on FDI inflow in China. The impact is different in terms of population density, investment in pollution control, and GDP in different regions. This paper ovides new ideas for environmental governance and the further utilization of foreign investment under the “new normal”.
Endotoxins Induced ECM-Receptor Interaction Pathway Signal Effect on the Function of MUC2 in Caco2/HT29 Co-Culture Cells
Authors: Wu Chenchen Wu , zhang Mingming , Hu Wenxiang , Tian Tian
Published: April 2022

Endotoxins are toxic substances that widely exist in the environment and can enter the intestine with food and other substances. Intestinal epithelial cells are protected by a mucus layer that contains MUC2 as its main structural component. However, a detailed understanding of the mechanisms involved in the function of the mucus barrier in endotoxin penetration is lacking. Here, we established the most suitable proportion of Caco-2/HT-29 co-culture cells as a powerful tool to evaluate the intestinal mucus layer. Our findings significantly advance current knowledge as focal adhesion and ECM-receptor interaction were identified as the two most significantly implicated pathways in MUC2 small interfering RNA (siRNA)-transfected Caco-2/HT-29 co-culture cells after 24 h of LPS stimulation. When the mucus layer was not intact, LPS was found to damage the tight junctions of Caco-2/HT29 co-cultured cells. Furthermore, LPS was demonstrated to inhibit the integrin-mediated focal adhesion structure and damage the matrix network structure of the extracellular and actin microfilament skeletons. Ultimately, LPS inhibited the interactive communication between the extracellular matrix and the cytoskeleton for 24 h in the siMUC2 group compared with the LPS(+) and LPS(-) groups. Overall, we recognized the potential of MUC2 as a tool for barrier function in several intestinal bacterial diseases.
COVID-19’un Türkiye’nin Dış Ticaretine Etkisi
Authors: PELİT İrem , IRMAK Esma
Published: April 2022

2019 Aralık ayında Çin'in Wuhan eyaletinde görülen, Dünya Sağlık Örgütü’nün pandemi olarak adlandırdığı COVİD-19 dünyayı etkisi altına almış ve ülke ekonomilerini zarara uğratmıştır. Salgının solum yoluyla bulaşması nedeniyle; insan sağlığına olumsuz etkilerini azaltmak için, hükümetlerce alınan yasaklar ve önlemler, dış ticaretinde negatif yönde ilerlemesine yol açmıştır. Küresel çapta arz-talep dengesizliği yaratarak üretim ve tüketimin daralmasına neden olmuş, ithalat ve ihracat durma noktasına gelmiştir. Bu olumsuzluklar neticesinde de küresel tedarik zinciri sekteye uğramıştır. Ülkelerin gelişmişlik seviyelerinin önemi kalmamıştır. Bu sürecin ne kadar devam edeceği belirsizliğini korumaktadır. Bu çalışmada, 2020 yılının mart ayında Türkiye de ortaya çıkarak etkisini göstermeye başlayan Covid-19'un, Türkiye’nin dış ticaret hacmine (2018-2021) etkisinin tespit edilmesi ve geleceğe yönelik politika önerileri yapılmıştır.
Validación del Modelo de Aceptación Tecnológica (TAM) para medir la competencia digital en estudiantes de educación primaria
Authors: Pino Varela Julio José
Published: April 2022

La legislación educativa española establece que el alumnado de Educación Primaria ha de adquirir la Competencia Digital como una de las Competencias Claves recomendadas por la Unión Europea en el European Framework for Key Competences for Lifelong Learning. La evaluación de las Competencias Clave supone un reto para el profesorado, pues en el proceso de aprendizaje se suele restringir el desarrollo competencial, lo que dificulta su medición. Este trabajo tiene como objetivo validar un instrumento eficaz para medir la competencia digital del alumnado de 5º y de 6º de educación primaria. En esta investigación han participado 170 alumnos de dos centros de Córdoba, con una edad media de 11.05 (DT=.775). Como instrumento de recogida de datos se utilizó el Technology Acceptance Model (TAM) para comprobar el nivel de la adquisición de la Competencia Digital. Los resultados nos muestran que el instrumento se divide en dos dimensiones: utilidad y disfrute, siendo estas dos escalas similares a las que Davis (1989) estableció en el inicio del TAM: utilidad y facilidad de uso. Teniendo en cuenta los resultados, se puede concluir que el TAM se muestra como herramienta válida y fiable para medir la competencia digital de los alumnos de primaria.
El uso de herramientas y recursos digitales (“SATÉLITES EDUCATIVOS DIGITALES”) como ayuda en la planificación, motivación y autorregulación del aprendizaje en Educación Superior
Authors: Jiménez Rodríguez Virginia , Calaforra Faubel Patricia Jara , Martínez Picazo Alejandro
Published: April 2022

Debido a la pandemia que se está viviendo mundialmente, el sistema educativo se ha visto forzado a virar hacia una metodología combinada de presencialidad reducida en las aulas con enseñanza online incrementando enormemente el uso de la tecnología de la información y la comunicación (TIC). Este estudio pretende, a partir de esta situación, analizar recursos y herramientas digitales (a las que se les ha llamado “Satélites Educativos Digitales”, por sus siglas SED) que se han puesto en marcha en la Educación Superior presentando los resultados obtenidos después de utilizarlos. Estas herramientas ayudan a la planificación y autorregulación del aprendizaje teniendo en cuenta la motivación. Concretamente, ha participado una muestra de 179 estudiantes (mayoritariamente identificada como femenina) de primero de grado de Trabajo Social de la Universidad Complutense de Madrid, en la asignatura de Psicología Básica. Se han comparado los resultados pretest con los obtenidos postest y muestran que el esfuerzo (variable incluida en las expectativas basadas en la percepción del control personal) está relacionado tanto con el autocontrol como con la planificación. Se han diferenciado diversos recursos digitales, la potencia motivacional que poseen alguno de ellos y se han visto las preferencias del alumnado por incluir este tipo de herramientas en las aulas.
Study on the Stimulation Effectiveness Evaluation of Large-Scale Hydraulic Fracturing Simulation Experiment Based on Optical Scanning Technology
Authors: Yang Hanzhi , Guo Yintong , Wang Lei , Bi Zhenhui , Guo Wuhao , Zhao Guokai , Yang Chunhe
Published: April 2022

Unconventional reservoirs such as gas shales and tight gas sands require technology-based solutions for optimum development because of the undeveloped matrix pores and poor permeability. Hydraulic fracturing is one of the most critical technologies. The quantitative characterization of hydraulic fractures is of great significance to the stimulation evaluation of the reservoir, but there is still a lack of fine, effective and systematic evaluation methods. 3D optical scanning technology is widely used in the quantitative characterization of rock fracture morphology for its advantages of high speed, convenience, high precision, and nondestructive testing. In this study, after the indoor hydraulic-fracturing simulation experiments, 3D optical scanning was used to visualize the fracture network. On this basis, two aspects of quantitative evaluation methods for stimulation effectiveness were established, including: (1) evaluating the local conductivity (permeability) of different fractures by cutting hydraulic-fracturing samples. Then combining local conductivity of different fractures with the overall stimulated reservoir area, which could be more reasonable to evaluate the stimulation scope of the reservoir; (2) calculating the fractal dimension (FD) of the 3D spatial structure based on the point-cloud processing, which could directly reflect the complexity of the fracture network. Finally, a new evaluation index for stimulation (Es) was established to comprehensively assess the stimulation effectiveness of the reservoir, which was applied and verified through the indoor fracturing simulation experiments of tight sandstone from the Ordos Basin, China.
Notch1-CD22-Dependent Immune Dysregulation in the SARS-CoV2-Associated Multisystem Inflammatory Syndrome in Children
Authors: Chatila Talal A. , Benamar Mehdi , Chen Qian , Chou Janet , Julé Amelie , Boudra Rafik , Contini Paola , Crestani Elena , Wang Muyun , Fong Jason , Lai Peggy , Rockwitz Shira , Lee Pui , Chan Tsz Man Fion , Altun Ekin Zeynep , Kepenekli Eda , Karakoc-Aydiner Elif , Ozen Ahmet , Boran Perran , Aygun Fatih , Onal Pinar , Sakalli Ayse Ayzit Kilinc , Cokugras Haluk , Gelmez Metin , Öktelik Fatma , Cetin Esin Aktaş , Zhong Yuelin , Taylor Maria , Irby Katherine , Halasa Natasha , Signa Sara , Prigione Ignazia , Gattorno Marco , Cotugno Nicola , Amodio Donato , Geha Raif , Son Mary Beth , Newburger Jane , Agrawal Pankaj , Volpi Stefano , Palma Paolo , Kiykim Ayca , Randolph Adrienne , Deniz Gunnur , Baris Safa , De Palma Raffaele , Schmitz-Abe Klaus , Charbonnier Louis-Marie , Henderson Lauren
Published: April 2022

Multisystem inflammatory syndrome in children (MIS-C) evolves in some pediatric patients following acute infection with SARS-CoV-2 by hitherto unknown mechanisms. Whereas acute-COVID-19 severity and outcome were previously correlated with Notch4 expression on regulatory T (Treg) cells, here we show that the Treg cells in MIS-C are destabilized in association with increased Notch1 expression. Genetic analysis revealed that MIS-C patients were enriched in rare deleterious variant impacting inflammation and autoimmunity pathways, including dominant negative mutations in the Notch1 regulators NUMB and NUMBL. Notch1 signaling in Treg cells induced CD22, leading to their destabilization in an mTORC1 dependent manner and to the promotion of systemic inflammation. These results establish a Notch1-CD22 signaling axis that disrupts Treg cell function in MIS-C and point to distinct immune checkpoints controlled by individual Treg cell Notch receptors that shape the inflammatory outcome in SARS-CoV-2 infection.
All-optical noise spectroscopy of a solid-state spin
Authors: Farfurnik Demitry , Singh Harjot , Luo Zhouchen , Bracker Allan , Carter Sam , Pettit Robert , Waks Edo
Published: April 2022

Noise spectroscopy elucidates the fundamental noise sources in spin systems, which is essential for developing spin qubits with long coherence times for quantum information processing, communication, and sensing. But noise spectroscopy typically relies on microwave coherent spin control to extract the noise spectrum, which becomes infeasible when there are high-frequency noise components stronger than the available microwave power. Here, we demonstrate an alternative all-optical approach to performing noise spectroscopy. Our approach utilises coherent Raman rotations of the spin state with controlled timing and phase to implement Carr-Purcell-Meiboom-Gill (CPMG) pulse sequences. Analysing the spin dynamics under these sequences enables us to extract the noise spectrum of a dense ensemble of nuclear spins interacting with a single spin in a quantum dot, which has thus far only been modelled theoretically. By providing large spectral bandwidths of over 100 MHz, our Raman-based approach could serve as an important tool to study spin dynamics and decoherence mechanisms for a broad range of solid-state spin qubits.
Some new results on stability and input to state stability of fuzzy differential equations
Authors: GHANMI Boulbaba
Published: April 2022

In this paper, we introduce a new notion of stability, namely generalized practical h −stability. Both generalized practical h −stability and generalized input-to-state practical h −stability are considered. Under Lyapunov techniques, some sufficient conditions are given which guarantee generalized practical h −stability of fuzzy differential equations. The generalized practical h −stability analysis is also accomplished with the help of the scalar h −stable functions.
Effects of supplementation with Shiitake powder, Lentinula edodes, on anti-oxidative activities and energy/ lipid metabolism in healthy dogs
Authors: Kusaba Akio , Okada Yuki , Ueno Hiromichi , Yamamoto Ichiro , Mori Yuichiro , Tanaka Norio , Arai Toshiro , Kawasumi Koh
Published: April 2022

Obesity is the number one health problem pets face. Effective food and supplement should be developed to improve anti-oxidative activities and energy /lipid metabolism in obese animals. In this study, we measured metabolites and hormone concentrations and enzymes activities related to anti-oxidant activities and energy /lipid metabolism in plasma of healthy dogs supplemented with shiitake powder to investigate effects of its supplementation on anti-oxidative function and energy /lipid metabolism in healthy dogs. Shiitake powder was supplemented with healthy dog at the high dose (800mg/kg body weights/day) and low dose (100mg/kg/day) for 4 weeks. In dogs supplemented with shiitake powder at the high dose, plasma SOD activities increased significantly and total cholesterol concentrations decreased and sirtuin1 mRNA expression increased in peripheral leukocytes. Plasma ALP and LDH activities tended to decrease in the high dose group. These reactions seemed to reflect of improvement of energy metabolism and hepatic function. Shiitake powder may ameliorate lipid metabolism in canine liver, and may improve anti-oxidative function and energy/lipid metabolisms in healthy dogs. To evaluate the usefulness of shiitake powder for obese dogs, further studies using overweight and obese dogs are needed. (186 words)
Factors influencing the improvement in external contracture following anterolateral total hip arthroplasty: A prospective study
Authors: Ohmori Takaaki , Kabata Tamon , Kajino Yoshitomo , Inoue Daisuke , Yamamuro Yuki , Taninaka Atsushi , Kataoka Tomoyuki , Saiki Yoshitomo , Yanagi Yu , Kato Satoshi , Yahata Tetsutaro , Tsuchiya Hiroyuki
Published: April 2022

Background External contracture of the hip joint occurs with the progression of hip osteoarthritis. It can be easily imagined that improvement of the external contracture can be expected with the posterior approach as it dissociates the short external rotator muscle group and the posterior tissue. However, improvement of external contracture with the anterior approach, which does not dissociate the posterior tissue, is unclear.　In this study, we examined the degree of external contracture improvement after anterolateral approach THA, its influencing factors, and the effect on lower limb function. Methods We prospectively examined 73 patients who underwent THA using an anterolateral approach for hip osteoarthritis of Crowe type 1 and 2. Lower limb rotation, leg lengthening, and various offsets in the natural position were measured using three-dimensional templating software based on computed tomography before and two weeks after surgery; factors related to lower limb rotation were investigated by multiple regression analysis. A functional evaluation, which are gait speed, knee extensor strength, functional reach test, and the Japanese Orthopaedic Association hip score, was performed one year after surgery. Results All functional outcomes significantly improved after THA. As for the setting of implants, the acetabular offset became shorter with the medialization of the cup as planned; the stem side could be compensated accordingly, and the global offset could be almost reproduced. The stem was inserted almost along the original anteversion. There were no postoperative dislocation cases. External contracture was improved by 4.7° ± 8.3° after anterolateral THA. Age and preoperative femoral external contracture were significant factors for the amount of improvement in femoral external contracture (adjusted R2: 0.492) and for the postoperative remaining external contracture (adjusted R2: 0.577), but they were not significantly correlated with lower limb function and the Japanese Orthopaedic Association hip score 1 year after surgery (p > 0.05). Conclusion Even anterolateral approach THA, which does not dissociate the posterior tissue, improved postoperative external contracture of the hip joint by about five degrees, and the stronger the preoperative external contracture, the greater the improvement. However, there was no significant correlation with lower limb function one year after surgery.
Triiodothyronine Regulates the Number and Morphological Development of Supporting Cells of organ of Corti During Critical Periods of Cochlear Development
Authors: Bai Xue , Xu Kai , Chen Sen , Xie Le , Qiu Yue , Sun Yu
Published: April 2022

Thyroid hormones are essential for cochlear development and normal auditory function. Previous studies reported that excessive triiodothyronine (T3) accelerates the development of cochlear morphology and causes deafness in rodents. However, the pathophysiologic mechanism of T3-induced hearing loss and its effect on the remodeling of the organ of Corti (OC) remains unclear. In this study, neonatal wild-type (WT) mice were given T3 at different postnatal time points, and then auditory brainstem responses (ABR) and morphological changes of the OC were analyzed. Mice treated with T3 at postnatal day 0 (P0 group) or P1 (P1 group) showed severe deafness with disordered stereocilia of the outer hair cells (OHCs), and impaired mechanoelectrical transduction function of OHCs. In addition, administration of T3 at P0 or P1 resulted in the overproduction of Deiter-like cells (Deiter’s cells, DCs, are supporting cells in the OC). These extra cells have phalangeal process structures similar to DCs, and are coupled with normal DCs by gap junctions. Furthermore, Sox2-haploinsufficient mice treated with T3 not only showed excess numbers of Deiter-like cells but also a large number of ectopic outer pillar cells (OPCs). In particular, these ectopic OPCs resulted in a great change in the morphology of the OC, forming double tunnels of Corti structures. Together, our study provides new evidence for the dual roles of T3 in regulating both hair cell and supporting cell development, suggesting that it is possible to increase the reserve of supporting cells.
Warming and predation risk only weakly shape size-mediated priority effects in a cannibalistic damselfly
Authors: Raczyński Mateusz , Stoks Robby , Sniegula Szymon
Published: April 2022

1. Differences in hatching dates can shape intraspecific interactions through size-mediated priority effects (SMPE), a phenomenon where bigger, early hatched individuals gain advantage over smaller, late hatched ones. While SMPE may be important for population dynamics, to what extent and how these are affected by key environmental factors such as warming and predation risk imposed by top predators remains unclear.2. In a laboratory experiment, we studied effects of warming (low and high temperature) and predation risk (presence and absence of predator cues of perch) on SMPE in life history and physiological traits in the cannibalistic damselfly Ischnura elegans. We induced SMPE by manipulating hatching dates, thereby creating four groups: non-mixed phenology early (E) and late (L) hatchers, and mixed phenology early (E+L) and late (L+E) hatchers. 3. We found strong SMPE for survival and emergence success, with the highest values in E+L larvae and the lowest values in L+E larvae. Neither temperature nor predator cues affected SMPE for these two life history traits. The other life history traits (development rate and mass at emergence) did not show SMPE, but were affected by temperature and predator cues.4. SMPE was found for protein content, but only in the high temperature treatment. The other physiological traits (immune function measured as phenoloxidase activity and fat content) showed fixed expressions across treatments, indicating decoupling between physiology and life history. 5. The results underline that SMPEs are trait-dependent, and only weakly affected by temperature and predation risk.
mRNA vaccine induces cytotoxic CD8+ T-cell cross-reactivity against SARS-CoV-2 Omicron variant and regulates COVID-19 severity
Authors: Nogimori Takuto , Suzuki Koichiro , Masuta Yuji , Yagoto Mika , Ikeda Mami , Katayama Yuki , Washizaki Ayaka , Kanda Hidenori , Takada Minoru , Minami Shohei , Kobayashi Takeshi , Takahama Shokichi , Yoshioka Yasuo , Yamamoto Takuya
Published: April 2022

Understanding the T-cell responses involved in inhibiting COVID-19 severity is crucial for developing new therapeutic and vaccine strategies. Here, we characterized SARS-CoV-2 spike-specific CD8+ T cells interacting with overlapping peptides on peripheral blood mononuclear cells from acute-phase COVID-19 patients. Relative to severe COVID-19, patients with mild COVID-19 had more frequent antigen-specific CD8+ T cells, and significantly increased SARS-CoV-2 spike-specific CD8+ T cells simultaneously expressing granzyme A, granzyme B, and perforin, suggesting that inducing highly cytotoxic CD8+ T cells during early infection suppresses COVID-19 severity. The BNT162b2 mRNA vaccine induced these antigen-specific CD8+ T cells in healthy donors, although lesser than in infected patients, and the induced subpopulation was not maintained long-term after second vaccination. Importantly, these CD8+ T cells showed cross-reactivity with the Delta and Omicron strains of SARS-CoV-2. Incorporating factors that efficiently induce CD8+ T cells with polyfunctional cytotoxic activity may improve future vaccine efficacy against such variants.
Impact of 1-week preoperative auto-CPAP treatment on postoperative outcomes in patients undergoing heart valve replacement surgery: a prospective randomized controlled trial
Authors: Ding Ning , Su Mei , Qi Xu , Ni Buqing , Zhang Shijiang , Zhang Xilong
Published: April 2022

Whether preoperative continuous positive airway pressure (CPAP) treatment improves postoperative outcomes in patients undergoing cardiac valve replacement (CVR) remains unknown. This tudy was to evaluate the effects of 1-week perioperative auto-continuous positive airway pressure (CPAP) treatment on postoperative heart and pulmonary outcomes in patients with obstructive sleep apnea (OSA) and valvular heart disease. Thirty-two patients with OSA and valvular heart disease were randomly assigned to 1-week CPAP (n = 15) group and non-CPAP treatments (n = 17) group. After the treatment, all patients underwent CVR surgery. The length of ICU and hospital stays, postoperative cardiac and respiratory complications were assessed and compared between the two groups. The results showed there was no significant difference in the baseline characteristics between the CPAP and non-CPAP treatment groups. The length of postoperative ICU and hospital stays, as well as the duration of mechanical ventilation were significantly reduced in the CPAP treatment group compared to the non-CPAP treatment group; however, there were no significant differences in cardiac complications (postoperative arrhythmias, pacemaker use, first dose of dopamine in the ICU, and first dose of dobutamine in the ICU), and respiratory complications (reintubation and pneumonia). We conclused that in patients underwent CVR, preoperative use of auto-CPAP for OSA significantly decreased the duration of mechanical ventilation, and postoperative stays in the ICU and hospital, but did not have an association with postoperative arrhythmias, pacemaker use, reintubation, or pneumonia.
Transient population dynamics drive the spread of invasive wild pigs in North America
Authors: Miller Ryan S , Tabak Michael A , Wolfson David W , Burdett Christopher L
Published: April 2022

Invasion of nonindigenous species is considered one of the most urgent problems affecting native ecosystems and agricultural systems. Mechanistic models that account for short-term population dynamics can improve prediction because they incorporate differing demographic processes that link the environmental conditions of a spatial location explicitly with the invasion process. Yet short-term population dynamics are rarely accounted for in spatial models of invasive species spread.Accounting for transient population dynamics, we predict the population growth rate and establishment probability of wild pigs following introduction into any location in North America. We compared predicted population growth rate with observed geographic rates of spread and found significant relationships between the annual rate of spread and population growth rates.We used geospatial data on the distribution of mast producing tree species (a principle forage resource of wild pigs) and agricultural crops that can replace mast in their diets to predict population dynamics using transient population simulations. We simulated populations under different initial population sizes (i.e. number of introduced individuals, often termed propagule size) and for different amounts of time following introduction. By varying the initial population size and simulation time, we were able to identify areas in North America with high probability for establishment of wild pigs if introduced. Our findings can be used to inform surveillance and removal efforts to reduce the potential for establishment and spread of wild pigs.
Two step anaerobic co-digestion of sesame oil cake and sewage sludge for sludge reduction and biogas production
Authors: Choi Hee-Jeong
Published: April 2022

The aim of this study was to investigate sewage sludge reduction and biogas production using two-stage anaerobic co-digestion of sesame oil cake and sewage sludge. In the first stage (acidogenic fermentation), sesame oil cake (SOC) was acid fermented to produce fermented sesame oil cake (FSOC). In the second step (anaerobic co-digestion), sewage sludge and FSOC were mixed in various ratios of (100:0 (R1), 70:30 (R2), 50:50 (R3), and 30:70 (R4)) and observed for 30 days at a mesophilization temperature of 25 ± 2 °C. In the anaerobic co-digestion using FSOC as a co-feedstock, the VS and TS removal were in the range of 53.7 - 64.9% and 42.6 - 53.2% for R2 and R3, respectively. The highest cumulative biogas production (1740.43 mL) and methane production (1253.11 mL) were achieved with the R3. In addition, R3 had the shortest reaction delay time (λ), and stabilization of the process was the fastest of all samples. The co-digestion performance index (CPI) was determined to be 1.29, 1.39, and 1.10 for R2, R3, and R4, respectively. The highest value for R3 confirmed the highest synergistic effect. This suggests the possibility of biogas production using sesame oil cake.
The effect of music interventions on fatigue in patients with hematological cancers: A systematic review and meta-analysis of randomized controlled trials
Authors: Sezgi̇n Merve Gozde , Bektas Hicran
Published: April 2022

PurposeTo systematically synthesize the effect of music interventions applied to patients with hematological cancer on fatigue.MethodsThe searches were conducted on PubMed, Web of Science, EBSCOhost/CINAHL Complete, Science Direct, Scopus, Cochrane Library, Ovid, ProQuest, and Springer Link databases until August 2021 without any year limitation. Comprehensive Meta-Analysis 3 software was used in the analysis of meta-analysis data. The meta-analysis was carried out following the PRISMA checklist. Risks of bias were examined by two independent researchers using the Cochrane Collaboration tool.ResultsSix randomized controlled trials consisting of 279 participants were included in the systematic review and meta-analysis. The count of music interventions in the included studies ranged between 1 and 8 sessions, each of which was 20 to 45 min long. The music interventions applied to patients with hematological cancers were found to be effective in reducing the severity of fatigue (95% Cl= 0.10~0.57; Hedge’s g=0.03; p=0.006).ConclusionsThe findings of the meta-analysis indicated that music interventions made important and positive contributions to reducing fatigue in patients with hematological cancer. Music interventions are a convenient method to reduce fatigue because they are comfortable and noninvasive. It will be beneficial to increase the awareness of nurses about the implementation of music interventions. It is recommended that music interventions applied to patients with a diagnosis of hematological cancer should be considered interventions that can be used together with other non-pharmacological or pharmacological methods to reduce fatigue.
Risk factors for oral mucositis in patients with solid tumors under treatment with cetuximab: a retrospective cross-sectional study.
Authors: Martins Joyce Ohana de Lima , Borges Marcela , Malta Cássia Emmanuela Nóbrega , Guerra Janaina Motta , Ribeiro Reverton Soares , Coelho Bruna Carolina , Silva Lúcio Flávio Gonzaga , Silva Paulo Goberlânio de Barros
Published: April 2022

Background
This study retrospectively analyzed the risk factors for oral mucositis (OM) during cetuximab treatment.
Methods
We screened patients using cetuximab and retrospectively evaluated the presence of OM based on medical records. We collected information from 2 years of evaluations. Patient medical records were reviewed to obtain data on chemotherapy cycle and dose, sex, age, primary tumor, TNM stage, and head and neck radiotherapy (HNR) history. The X2 test and multinomial logistic regression were used for statistical analysis (SPSS 20.0, p < 0.05).
Results
Among 1831 patients, OM was showed in 750 in any grade (41%), during cetuximab treatment. Most patients were female (n = 944, 51.6%), < 70years-old (n = 1149, 62.8%), had larynx cancer (n = 789, 43.1%) in T4 (n = 579, 47.7%), N0 (n = 509, 52.6%) stages. Primary tumor surgery was performed in 1476 (80.6%) patients, radiotherapy in 606 (33.1%) patients and cetuximab protocols most used involved up to four cycles (n = 1072, 58.5%) of < 400mg (n = 996, 54.4%) cetuximab doses. Female (OR [odds ratio] = 2.17, CI95% = 1.26–3.75), > 70 years-old patients (OR = 16.02, CI95% = 11.99–21.41), with HHNR (OR = 1.84, 1.41–2.40), treated with > 4 cycles (OR = 1.52, CI95% = 1.16–2.01) and high doses of cetuximab (OR = 3.80, CI95% = 2.52–5.71) are the greatest risk factors for OM.
Conclusion
Since the clinical benefit of cetuximab in the treatment of older patients is limited and there is a high OM, especially in women with head and neck treated with radiotherapy, high doses and a high number of cetuximab cycles must be administered with caution.