bluuebunny/crossref_metadata_2025 huggingface dataset:
Plan De Desarrollo Turístico Como Alternativa De Dinamismo Socio Economico En La Parroquia Nueva Loja, Cantón Lago Agrio, Provincia De Sucumbíos
Authors: Grefa Edith Jessica Cerda , Bernal Catalina Margarita Verdugo , Guerra Juan Hugo Rodríguez , Sampedro Otto Fernando Balseca , Moyota Paulina Beatriz Díaz , Paredes Oscar Iván Granizo , Layedra Jaime Robert Guevara
Published: April 2017

This paper elaborates a plan for tourist development in the county of Nueva Loja, canton Lago Agrio, province of Sucumbíos, Ecuador, which was based on bibliographic review, field trips and participatory workshops. These steps validated a diagnosis related to physical, cultural, socioeconomic, and political dimensions of the territory. The inventory of tourist attractions in Nueva Loja followed the methodology of the Ecuador Ministry of Tourism, 2004, resulting in identification of seven natural attractions, up to Level II, and seven intangible cultural attractions. To determine the profile of domestic and foreign tourists wishing to get to know the county, a concurrent market survey was conducted. A situational analysis was carried out, in which institutions associated with economic development in the county were identified, as well as policies, objectives and strategies that serve to strengthen tourism in the region. To ensure the sustainability of four programs and ten projects, an investment of USD 454,700 is required. The plan establishes a basis for improving tourism, under a scheme of sustainability, resulting in economic benefits that will be experienced by its inhabitants. The implementation of the plan is recommended, since it is designed according to the needs and the local reality for the sustainable development of tourism.
#VELHAPRAISSO: a representação da velhice feminina em campanha publicitária de natura
Authors: Castilhos de Araujo Denise
Published: April 2017

Este artigo tem por objetivo refletir acerca da representação social da velhice feminina em um filme publicitário da campanha #velhapraisso, da marca de cosméticos brasileira Natura. Esta marca, nos últimos anos, tem procurado valorizar a beleza das brasileiras, a partir da exaltação das diferenças das belezas presentes no Brasil. Na campanha selecionada, a Natura aborda uma temática relevante socialmente, a velhice, representando-a em uma peça publicitária e propondo, também, a discussão sobre o assunto em ações de interação com as consumidoras da marca em seu site. Na reflexão proposta neste estudo, trabalha-se com a teoria das representações sociais, a partir das propostas teóricas de Moscovici (1978) e Jodelet (2001). E, para esses autores, as representações sociais podem ser consideradas criações dos grupos sociais, as quais auxiliam os indivíduos a reconhecerem comportamentos mais adequados para um momento ou outro, bem como para identificarem e solucionarem certos problemas. O que se propõe, então, é a identificação da representação social da velhice no referido filme publicitário, ou seja, como a marca Natura apresenta a velhice para suas consumidoras. Ao final dessa reflexão, identificou-se que o tratamento dado à velhice abrange duas dimensões, a da idade propriamente dita, e a social, que se refere à adequação de comportamentos sociais, por parte das mulheres, em determinadas situações.
APROPRIAÇÕES MIDIÁTICAS DO FEMINISMO NEGRO NA CONTEMPORANEIDADE BRASILEIRA
Authors: Johnson Telma Sueli Pinto , Farnese Pedro Augusto , Ribeiro Marcela Xavier
Published: April 2017

Este artigo examina apropriações midiáticas pelo feminismo negro baseadas em reflexões teórico-conceituais sobre a problemática da comunicação em sociedades midiatizadas e suas relações com a literacia midiática. O Instituto da Mulher Negra Geledés, fundado em 1998 no período da redemocratização brasileira, constitui-se no objeto de investigação. O movimento Geledés foi observado e mapeado em sua página no site de rede social Facebook, durante um período consecutivo de oito semanas em 2016, com o propósito de identificar modalidades de interações entre seus visitantes. A análise dedica-se, para além das postagens do Geledés, a apreender e compreender o que acontece na esfera da recepção quando se trata de tipos de usos, apropriações e produções de sentidos. Um construto metodológico baseado na Cartografia de Controvérsias (CC) foi operacionalizado para analisar as interações dos actantes sociais do Geledés no Facebook, revelando predominância de interações passivas e elevado número de comentários participativos desqualificados sob a ótica do debate público racional.
A REPRESENTAÇÃO DAS MULHERES EM FOTOS JORNALÍSTICAS DE FAVELAS DO RIO DE JANEIRO
Authors: Barcelos Janaina Dias
Published: April 2017

Este artigo consiste em um desdobramento da análise realizada na tese de doutorado “Imagem e produção de sentido sobre favelas cariocas em fotos jornalísticas”, apresentada em janeiro de 2016. A partir do corpus desse estudo, constituído de 302 imagens de favelas do Rio de Janeiro, publicadas nos meses de setembro, outubro e novembro dos anos 2010, 2012 e 2014, fizemos um recorte com fotos que retratam mulheres adultas como protagonistas. O objetivo era verificar qual a representação social das mulheres situadas no espaço favela e quais imaginários sociodiscursivos esse modo de apresentá-las poderia engendrar, se reforçaria estereótipos negativos cristalizados ou se daria a ver alguma complexidade e diversidade. Tal discussão é fundamental uma vez que os meios de comunicação produzem subjetividades ao construir seus discursos.
JORNALISMO E DISCURSO: as representações sobre o leitor nas páginas de O Conciliador do Maranhão (1821-1823)
Authors: Pinheiro Roseane Arcanjo , Hohlfeldt Antonio
Published: April 2017

O trabalho tem como objetivo analisar o discurso do jornal O Conciliador do Maranhão sobre as intenções e a identidade do leitor da publicação através da seção “Correspondência”. O impresso, que circulou entre 1821 a 1823, por meio de iniciativa do governo da província, foi marco da constituição do campo jornalístico na cidade de São Luís em uma conjuntura de alianças locais e acomodação política frente às mudanças no regime absolutista português. Os sentidos produzidos sobre os leitores envolveram as questões políticas e as relações sociais da época, construídas em meio a um processo complexo de trocas entre o jornal e os leitores.
OS RECADOS DAS ELEIÇÕES MUNICIPAIS DE 2016: manutenção do status quo ou mudança?
Authors: Oliveira Adriano
Published: April 2017

Quais as conclusões que a eleição municipal de 2016 oferta? Este artigo tem o objetivo de responder tal indagação. Ela nasceu em virtude de um aparente consenso observado no espaço midiático de que os resultados do último pleito municipal mostrou que os eleitores estão decepcionados com os políticos e de que existe onda conservadora no Brasil. Encaro estas assertivas como hipótese. Por isto, as testo através da análise de diversos indicadores, quais sejam: (1) Percentuais da abstenção eleitoral e votos brancos e nulos; (2) Quantidade de prefeituras conquistadas pelos partidos políticos; (3) Número de competidores; (4) E taxa de penetração eleitoral por parte das agremiações partidárias. Cinco eleições municipais são analisadas.
AS DUAS FACES DO SEXISMO NA MÍDIA: como Marcela Temer e Dilma Rousseff (PT) são retratadas pela Veja e IstoÉ
Authors: Veloso Ana Maria Conceição , Vasconcelos Fabíola Mendonça de , Ferreira Laís
Published: April 2017

A forma como a mídia brasileira retrata a mulher no campo político é um dos aportes deste artigo, que analisa as reportagens de duas revistas semanais, a Veja e a IstoÉ: enquanto a primeira tenta mostrar uma vice-primeira-dama, Marcela Temer, como “bela, recatada e do lar”, a segunda traz uma presidenta da República, Dilma Rousseff, histérica, destemperada, cuja manchete de capa é “As explosões nervosas da presidente”. As duas edições são veiculadas no contexto da votação do impeachment da presidenta Dilma Rousseff (PT), votado na Câmara Federal em  abril de 2016 e, no Senado, em maio e em agosto do mesmo ano. Utilizando como referenciais teóricos a Economia Política da Comunicação, o trabalho mostra o caráter patriarcal, misógino e preconceituoso das publicações, que reproduzem valores consoantes a formações ideológicas sexistas.
INSTAGRAM E A DESQUALIFICAÇÃO DO FEMININO NAS ELEIÇÕES PRESIDENCIAIS BRASILEIRAS EM 2014
Authors: Panke Luciana , Lima Alice
Published: April 2017

Este artigo analisa a desqualificação do feminino nas eleições presidenciais brasileiras em 2014, tomando como exemplo os comentários contra a presidenta Dilma Rousseff (PT), durante o segundo turno da campanha presidencial em 2014, publicadas em seu perfil oficial no Instagram. Para isso, foram analisados os comentários dos sete posts com mais “curtidas”, de acordo com as categorias de desqualificação “mundo”, “partido” ou “candidato” (PANKE, 2012). A pesquisa aponta que as palavras direcionadas a Dilma apresentam críticas relacionadas ao gênero em detrimento do conteúdo político. Para interpretar os dados, foram utilizados autores como Luís Felipe Miguel e Flávia Biroli (2014), Marta Lamas (2013) e Luciana Panke (2015), que abordam questões de gênero. De acordo com os dados encontrados, 62% das desqualificações foram direcionadas à “candidata”, 22 a “mundo” e 16% a “partido”.
Sodium and Potassium Intake in Healthy Adults in Thessaloniki Greater Metropolitan Area—the SING (Salt Intake in Northern Greece) Study
Authors: Vasara Eleni , Marakis Georgios , Breda Joao , Skepastianos Petros , Hassapidou Maria , Kafatos Anthony , Rodopaios Nikolaos , Koulouri Alexandra A. , Cappuccio Francesco P.
Published: April 2017

A reduction in population sodium (as salt) consumption is one of the most cost-effective strategies to reduce the burden of cardiovascular disease and it is a global health priority. High potassium intake is also recommended to reduce cardiovascular disease. To establish effective policies for setting targets and monitoring effectiveness within each country, the current level of consumption should be known. Greece lacks data on actual sodium and potassium intakes. The aim of the present study was therefore to assess dietary salt (using sodium as biomarker) and potassium intakes in a sample of healthy adults in northern Greece and to determine whether adherence to a Mediterranean diet is related to different sodium intakes or sodium-to-potassium ratio. A cross-sectional survey was carried out in Thessaloniki greater metropolitan area (northern Greece) (n=252, aged 18-75 years, 45.2% males). Participants’ dietary sodium and potassium intakes were determined by 24h urinary sodium and potassium excretions. In addition, we estimated their adherence to Mediterranean diet by the use of an 11-item MedDietScore (range 0-55). The mean sodium excretion was 175 (SD 72) mmol/day, equivalent to 4,220 (1,745) mg of sodium or 10.7 (4.4) g of salt per day and potassium excretion was 65 (25) mmol/day, equivalent to 3,303 (1,247) mg/day. Men had higher sodium and potassium excretions compared to women. Only 5.6% of the sample had salt intake <5g/d, which is the target intake recommended by the WHO. Mean sodium-to-potassium excretion ratio was 2.82 (1.07). There was no significant difference in salt or potassium intake or their ratio across MedDietScore quartiles. No significant relationships were found between salt intake and adherence to Mediterranean diet, suggesting that the perception of the health benefits of the Mediterranean diet does not hold when referring to salt consumption. These results suggest the need for a larger nation-wide survey on salt intake in Greece and underline the importance of continuation of salt reduction initiatives in Greece.
Automatic Localization Algorithm for Ultrasound Breast Tumors Based on Human Visual Mechanism
Authors: Xie Yuting , Chen Ke , Lin Jiangli
Published: April 2017

Human visual system (HVM) can quickly localize the most salient object in scenes, which has been widely applied on natural image segmentation [15]-[19]. In ultrasound (US) breast images, compared with background areas, tumor is more salient because of its higher contrast. In this paper, we develop a novel automatic localization method based on HVM for automatic segmentation of ultrasound (US) breast tumors.

First, the input image is smoothed by convolution with a linearly separable Gaussian filter and then subsampled into a 9-layer Gaussian pyramid. Then intensity, blackness ratio, and superpixel contrast features are combined to compute saliency map, in which Winner Take All algorithm is used to localize the most salient region, presenting with a circle on the localized target. Finally the circle is taken as the initial contour of CV level set to finish the extraction of breast tumor.

The localization method has been tested on 400 US beast images, among which 378 images have higher saliency than background areas and succeed in localization, with high accuracy 92.00%. The HVM localization method can be used to localize the tumors, combined with this method, CV level set can achieve the fully automatic segmentation of US breast tumors.

By combing intensity, blackness ratio and superpixel contrast features, the proposed localization method can successfully avoid the interference caused by background areas with low echo and high intensity. Moreover, multi-object localization of US breast images can be considered in future employment.
Full Spectrum Analytical Channel Design with the Capacity/Supply Ratio (CSR)
Authors: Stroth Travis R. , Bledsoe Brian P. , Nelson Peter A.
Published: April 2017

Analytical channel design tools have not advanced appreciably in the last decades, and continue to produce designs based upon a single representative discharge that may not lead to overall sediment continuity. It is beneficial for designers to know when a simplified design may be problematic and to efficiently produce alternative designs that approximate sediment balance over the entire flow regime. The Capacity/Supply Ratio (CSR) approach, an extension of the Copeland method of analytical channel design for sand channels, balances the sediment transport capacity of a design reach with the sediment supply of a stable upstream reach over the entire flow duration curve (FDC) rather than just a single discharge. Although CSR has a stronger physical basis than previous analytical channel design approaches, it has not been adopted in practice because it can be a cumbersome and time-consuming iterative analysis without the use of software. We investigate eighteen sand-bed rivers in a comparison of designs based on the CSR approach and five single-discharge metrics: the effective discharge (Qeff), the 1.5-year recurrence interval discharge (Q1.5), the bankfull discharge (Qbf), and the discharges associated with 50th (Qs50) and 75th (Qs75) percentiles of the cumulative sediment yield curve. To facilitate this analysis we developed a novel design tool using the Visual Basic for Applications (VBA) programming language in Excel® to produce stable channel slope-width combinations based on the CSR methodology for both sand- and gravel-bed streams. The CSR Stable Channel Design Tool’s (CSR Tool) code structure was based on Copeland’s method in SAM and HEC-RAS (Hydrologic Engineering Center’s River Analysis System) and was tested with a single discharge to verify outputs. The Qs50 and Qs75 single-discharge designs match the CSR output most closely, followed by the Qbf, Qeff, and Q1.5. The Qeff proved to be the most inconsistent design metric because it can be highly dependent on the binning procedure used in the effectiveness analysis. Furthermore, we found that the more rigorous physical basis of the CSR analysis is potentially most important in designing ‘labile’ channels with highly erodible substrate, high perennial flow ‘flashiness,’ low width-to-depth ratio, and high incoming sediment load. The CSR Tool provides a resource for river restoration practitioners to efficiently utilize in-depth design techniques that can promote sediment balance in dynamic fluvial systems.
Approximate Information and Accelerating for High-throughput Heterogeneous Data Analysis with Linear Mixed Models
Authors: Zhu Shengxin
Published: April 2017

Linear mixed models are frequently used for analysing heterogeneous data in a broad range of applications. The restricted maximum likelihood method is often preferred to estimate co-variance parameters in such models due to its unbiased estimation of the underlying variance parameters. The restricted log-likelihood function involves log determinants of a complicated co-variance matrix. An efficient statistical estimate of the underlying model parameters and quantifying the accuracy of the estimation requires the first derivatives and the second derivatives of the restricted log-likelihood function, i.e., the observed information. Standard approaches to compute the observed information and its expectation, the Fisher information, is computationally prohibitive for linear mixed models with thousands random and fixed effects. Customized algorithms are of highly demand to keep mixed models analysis scalable for increasing high-throughput heterogeneous data sets. In this paper, we explore how to leverage an averaged information splitting technique and dedicate matrix transform to significantly reduce computations and to accelerate computing. Together with a fill-in reducing multi-frontal sparse direct solver, the averaged information splitting approach improves the performance of the computation process.
Port Waste Management in the Baltic Sea Area: A Four Port Study on the Legal Requirements, Processes and Collaboration
Authors: Svaetichin Irina , Inkinen Tommi
Published: April 2017

The cruise ship industry has become a well-implemented industry in the Baltic Sea area, and each year, the number of cruise ship passengers rises steadily. Efficient waste management in cruising ports around the Baltic Sea is a crucial element in minimizing environmental impacts. This research involves the four selected ports of Copenhagen, Helsinki, Stockholm and Tallinn. The study applies statistics and interview data to the analysis of waste management systems for cruise ship-generated waste. The interview data involves 14 executives and professionals responsible for environmental issues and decision making in their respective ports. The interviews highlighted the need for standardized environmental legislation and related procedures, which would result in coherent measurement systems. These systems would enable transparent environmental monitoring, thus maintaining the ports’ competitiveness. A common environmental legislation would support the emerging waste management system for the whole Baltic Sea area. We suggest that ports should focus on handling specific types of wastes and collaborate as a spatial network. Specialization to allow discharge of certain fractions of waste is essential. The paper concludes by addressing demands for future research, particularly vessel- and customer behavior focused studies.
Multistage DC-DC Step-Up Self Balanced and Magnetic Component Free Converter for Photovoltaic Applications – Hardware Implementation
Authors: Bhaskar Mahajan Sagar , Padmanaban Sanjeevikumar , Blaabjerg Frede
Published: April 2017

This article presents a self balanced multistage DC-DC step-up converter for photovoltaic applications. Proposed converter topology is designed for unidirectional power transfer and provides a doable solution for photovoltaic applications where voltage is required to be stepped up without magnetic components. The output voltage obtained from renewable sources will be low and must be stepped up by using a DC-DC converter for photovoltaic applications. (2K-2) diodes and (2K-2) capacitors along with two semiconductor switch are used in the proposed converter to obtain an output voltage which is (K+1) times the input voltage. The conspicuous features of proposed topology are i) Magnetic components free ii) Continuous input current iii) Low voltage rating semiconductor devices and capacitors iv) Modularity v) Easy to add a higher number of levels to increase voltage gain vi) Only two control switches with alternating operation and simple control. The proposed converter has been designed with rated power of 60W, input voltage is 24V, output voltage is 100V and switching frequency is 100 kHz. The performance of the converter is verified through experimental and simulation results.
Polyamine Application Effects on Gibberellic Acid Content in Creeping Bentgrass during Drought Stress
Authors: Krishnan Sanalkumar , Merewitz Emily B.
Published: April 2017

Polyamines (PAs), spermine (Spm), and spermidine (Spd) may enhance the abiotic stress tolerance and growth of creeping bentgrass (Agrostis stolonifera). Growth chamber studies were conducted to investigate the effect of PA application on the physiological response and hormone content in creeping bentgrass ‘Penn-G2’ under drought. Spm (1 mm) and Spd (5 mm) were applied exogenously under drought or well-watered conditions. PA-treated plants maintained significantly higher turf quality (TQ), relative water content (RWC), photochemical efficiency, and membrane health while maintaining lower canopy temperature. Spm at the 1-mm rate had a 2.46-fold higher osmotic adjustment (OA) at 10 d compared with control plants. A greater content of gibberellic acid (GA) isoforms (GA1, GA4, and GA20) were observed compared with controls during both studies for PA-treated plants under drought. After 7 days of drought stress in Expt.1, GA1 levels were 3.26 higher for Spm 1-mm-treated plants compared with drought controls. GA4 contents were 69% and 65% higher compared with drought-stressed-untreated plants for Spd 5-mm application after 9 and 11 days. Higher levels of GA20 were observed at 10 days (Spd 5 mm, 108.9% higher) due to PA treatment compared with drought controls. In addition to differential regulation of GA isoforms, we observed enhanced abscisic acid (ABA) due to PA application; however, not on a consistent basis. This study showed that PA application may play a role in GA1, GA4, and ABA accumulation in creeping bentgrass ‘Penn G-2’ under drought stress.
Development and Characterization of Molecular Markers Associated with Female Plants in Muscadine Grape
Authors: Conner Patrick , Conner Joann , Catotti Paige , Lewter Jennifer , Clark John R. , Biasi Luiz A.
Published: April 2017

Muscadine (Vitis rotundifolia Michx.) vines may be male (M), female (F), or hermaphroditic (H). Male flowers have only filaments and anthers, whereas female and hermaphroditic flowers are morphologically perfect. Female flowers are distinguished from hermaphroditic flowers by their reflexed stamens (as opposed to upright) and nonfunctional pollen. Primers derived from previously identified candidate genes located at the sex locus of Vitis vinifera L. were used to generate amplicons from M, F, and H muscadine cultivars. Sequence analysis of the amplicons revealed insertion/deletion (indel) polymorphisms in a trehalose-6-phosphate phosphatase (TPP) gene (VR006) and a WRKY transcription factor 21 gene (VR009). Primers were designed to create diagnostic markers for each indel polymorphism. Associations between the marker alleles and the plant sex trait were examined in a wide range of muscadine germplasm and in segregating populations derived from F × H, F × M, and H × H crosses. VR006 produced a codominant marker that was able to differentiate the female-associated allele from the male- and hermaphroditic-associated alleles. The marker was able to detect female plants and will be suitable for screening breeding program progenies. VR009 was able to detect the presence of the female allele in most germplasm, but a crossover event appears to have separated the marker from the sex locus in some germplasm. As shown in previous muscadine genetic studies, H × H-derived populations produced male seedlings. Marker analysis of these populations indicates that male flowers only occur in seedlings which are heterozygous for F- and H-associated marker alleles and inheritance of flower type in muscadine remains unclear.
Inhibition of Ethylene Biosynthesis and Perception by 1-Methylcyclopropene and Its Consequences on Chlorophyll Catabolism and Storage Quality of ‘Bosc’ Pears
Authors: Xie Xingbin , Fang Congbing , Wang Yan
Published: April 2017

Bosc is a winter cultivar of european pear (Pyrus communis) that has a relatively short storage life partially due to a high ethylene production rate (EPR) during cold storage. ‘Bosc’ pears were harvested at commercial maturity and treated with gas 1-methylcyclopropene (1-MCP) at 0, 0.15, and 0.3 µL·L−1 and stored at −1.1 °C for 8 months. Results indicated that all 1-MCP treatments inhibited EPR and respiration rate (RR), retarded the degradation of chlorophyll and titratable acidity (TA), and extended storage quality; but inhibited ripening capacity. 1-MCP at 0.15 and 0.3 µL·L−1 had the same efficacy on keeping fruit quality although its higher rate was more efficient on inhibiting EPR and RR. The expression of ethylene synthesis genes (PcACS1, PcACS2, PcACS4, PcACS5, and PcACO1) and receptor genes (PcETR1, PcETR2, and PcERS1) was upregulated in control fruit during storage and they were downregulated significantly by 1-MCP treatments. In contrast, the ethylene receptor genes of PcETR5 and PcCTR1 were downregulated in control fruit during storage and were unaffected by 1-MCP treatments. Although the transcription levels of chlorophyll degradation genes PcPPH, PcNOL, PcSGR, PcRCCR, PcNYC, and PcPAO were all upregulated in control fruit during storage and downregulated by 1-MCP; only PcCHL was downregulated in the control and 1-MCP had no consistent effect on it. The relationship of ethylene biosynthesis/perception with chlorophyll degradation and storage quality in european pears was discussed.
Loss of CD20 Expression in Follicular Lymphoma after Program Anti-Tumor Therapy Including Rituximab: Literature Data and Case Report
Authors: Volodina Ol'ga Mikhailovna , Kupryshina N.A. , Falaleeva N.A. , Doronin V.A. , Mozhenkova A.V. , Frenkel' M.A. , Sorokin E.N. , Kokosadze N.V. , Tupitsyn N.N. , Tumyan G.S. , Osmanov E.A.
Published: April 2017

It is the first description of a case of follicular lymphoma with a loss of CD20 antigen expression during the anti-tumor treatment including rituximab in the NN Blokhin Russian Cancer Research Center. The article discusses the tactics of further management of such patients and the effect of the CD20-negative status of follicular lymphoma tumor cells acquired during immunochemotherapy.
Effect of Patients’ Endocrine Status on Effectiveness of Treatment with Rituximab: State of the Art
Authors: Komoza Yuliya Valer'evna , Komoza V.A. , Chernavskii S.V. , Rukavitsyn O.A.
Published: April 2017

The non-Hodgkin’s lymphoma morbidity rate is gradually increasing, and its peak is registered in patients aged 4560 years. At the same time, the world population steadily becomes older. Monoclonal antibodies (Rituximab) have been used in the treatment of patients with CD20-positive lymphomas for more than 20 years. The use of this drug enhanced the effectiveness of the therapy significantly. However, when patients were divided into groups by age and sex, better results were obtained in the group of women over 60 years. The review presents the results of several studies which have analyzed the effectiveness of rituximab-based schemes in patients depending on their sex and age, using different dosages and administration regimens. The article also presents our personal conclusions about the possible causes of the differences in efficacy of the drug in some patient populations. Identification of the causes contributing to the improvement of the effectiveness of rituximab in elderly women may significantly change approaches to the treatment of lymphomas in patients of both sexes.
Dasatinib in Firstand Second-Line Therapy of Chronic Myeloid Leukemia: Efficacy, Safety and Quality of Life
Authors: Ionova Tat'yana Ivanovna , Bulieva N.B. , Vinogradova O.Yu. , Gritsenko T.A. , Kozlova L.K. , Kuchma G.B. , Lomaia E.G. , Machyulaitene E.R. , Nikitina T.P. , Novitskaya N.V. , Rodionova A.Yu. , Usacheva E.I. , Shneider T.V.
Published: April 2017

Background & Aims. The article presents results of two observational, prospective, multicenter studies “Quality of Life, Symptom Profile, and Adherence to Treatment in Adult Patients with Newly Diagnosed Chronic Phase Chronic Myeloid Leukemia Receiving Dasatinib” (20122015) and “Quality of Life and Symptom Profile in Imatinib-Resistant or Intolerant Patients with Chronic Myeloid Leukemia” (2011-2014). Methods. Data of 107 patients with chronic myeloid leukemia in chronic phase were involved in the real-world analysis - 32 newly diagnosed patients on first-line treatment with dasatinib or after yearly switch to dasatinib after ima-tinib treatment failure and 75 imatinib-resistant or intolerant patients on second-line treatment with dasatinib. Treatment effectiveness and safety of dasatinib were assessed during first- and second-line dasatinib treatment using clinical outcomes as well as quality of life and symptom profile assessment. Results. The real-world data obtained during observational study in limited population of CML patients conform the results of clinical trials devoted to evaluation of treatment efficacy and safety of dasatinib treatment in first- and second-line treatment and demonstrate the importance of patient-reported outcomes. Patient's quality of life improved within 12 months of the first-line dasatinib therapy according to the following scales: role physical functioning, pain, vitality, social functioning and role emotional functioning. The most pronounced and clinically significant improvement was observed for the role emotional functioning (51.1 vs. 68.9). During the second-line dasatinib treatment, stabilization of quality of life parameters was registered for the following scales: vitality, social functioning, mental health, and pain. Significant improvement of the Integral Quality of Life Index was observed (p < 0.05). Positive dynamics of relevant symptoms was registered. The symptom severity decreased during both the first- and second-line therapy. Conclusion. Quality of life and symptom assessment in CML patients contribute to a better disease control in accordance with the principles of risk-adaptive therapy.
A Case Report of Myeloid Sarcoma in a Child
Authors: Valiev Timur Teimurazovich , Kovrigina A.M. , Panferova T.R. , Ushakova T.L. , Serebryakova I.N. , Tupitsyn N.N. , Grivtsova L.Yu. , Matveeva I.I. , Mikhailova E.V. , Popa A.V. , Menkevich G.L.
Published: April 2017

The diagnosis of myeloid tumors is based on a complex approach and causes significant difficulties especially in young children. Morphologic, immunologic, cytogenetic, molecular and biologic data on myeloid sarcoma are presented based on the literature data and own clinical case. Treatment results of myeloid sarcoma (especially in the high risk group) are unsatisfactory and should be improved.
Cytogenetic and Molecular Genetic Prognostic Factors of Acute Myeloid Leukemia
Authors: Misyurin Andrei Vital'evich
Published: April 2017

The review presents data on the diagnostic and prognostic value of cytogenetic and molecular genetic markers ol acute myeloid leukemia (AML). It demonstrates that some cases, different types of AML subdivided on the basis ol clinical and morphological characteristics earlier may be distinguished based on identification of specific genetic and chromosomal defects. However, some repeated chromosomal abnormalities may be detected in AML patients that may be assigned to different variants based in clinical and morphocytochemical signs. At present, it is widely accepted that changes in the karyotype are the key prognostic factors which are more important than criteria based on morphological and cytochemical signs. Therefore, the risk-adaptive therapy of AML should be chosen based on the cytogenetic test findings. The review contains a section discussing gene mutations known to date that may affect the AML treatment outcome.
MEMORIA Y OLVIDO EN GUADALUPE AÑOS SIN CUENTA
Authors: Fonnegra Osorio Claudia Patricia
Published: April 2017

El texto dramático Guadalupe años sin cuenta del grupo teatral La Candelaria de Bogotá, se inscribe enuna propuesta estética brechtiana y a partir de ella recrea la forma en que el campesino del Llano recuerdala muerte de Guadalupe Salcedo Unda. Sin embargo, no se trata de mostrar un escueto fragmento históricoque se reduce a la denuncia panfletaria, magistralmente la compañía teatral reconstruye testimoniosignorados sobre las luchas y frustraciones de los campesinos de los años cincuenta. A partir de una interpretaciónde los planos sintagmático y paradigmático, este texto busca mostrar cómo en Guadalupe añossin cuenta se apuesta a la configuración de una memoria colectiva plural, la cual pretende superar visionesparciales y homogéneas de la historia nacional colombiana.
APROXIMACIÓN A LA NOCIÓN DE POSMODERNIDAD EN TERAPIA FAMILIAR SISTÉMICA
Authors: Marín Rosa Alejandra , Ramírez Giraldo Natalia María , Valderrama Vélez Katterin
Published: April 2017

El presente artículo surge de la revisión documental, frente a la noción de posmodernidad y su relación con la Terapia Familiar Sistémica. Partiendo de artículos de investigación documental, biblioteca y demás medios de información.  La revisión documental arrojó dos categorías principales que fueron Razón vs Lenguaje, y enfoques de la terapia posmoderna, evidenciando así la necesidad de mostrar la heterogeneidad de la posmodernidad a partir de la negación de los metarrelatos modernos, pero reconociendo el interés de no abandonar la modernidad desde la objetividad y la razón.
LA MUJER COMO DISCÍPULA Y APÓSTOL EN LAS PRÁCTICAS EVANGELIZADORAS DE LA IGLESIA, DESDE JESÚS HASTA NUESTROS DÍAS
Authors: Fernández Terrones Gloria Maribel
Published: April 2017

Este trabajo intenta profundizar en la actuación evangelizadora de la mujer a lo largo de la historia de la Iglesia hasta nuestros días, en la cual ella ha encarnado y llevado a la práctica su ser de discípula y enviada de Jesucristo.  La apostolicidad femenina hasta hoy discutida y negada por el Magisterio de la Iglesia católica, hunde sus raíces en la persona de Jesús, el Dios encarnado en nuestra historia; pero su no reconocimiento influye en la restricción de la mujer al acceso al sacerdocio ministerial.       No obstante el Pueblo de Dios interpelado por la realidad actual y guiado por el Espíritu, hace un llamado de volver a las fuentes para desde ahí avivar el mensaje evangélico y resinificar las costumbres culturales revestidas de Tradición que perduran en él. El propósito es construir para nuestros días una Iglesia universal al servicio del Reino, centrada en Jesucristo y cimentada en los Apóstoles, una Iglesia llamada a dar testimonio del amor de Dios entre los hombres.      En nuestros días, la evangelización nos exige salir del círculo habitual para ir al encuentro de los hermanos como lo hizo Jesús. En todos los rincones de la tierra muchas personas están deseosas de Dios y sedientas de la presencia sacramental de Jesucristo; a estos lugares llega la presencia femenina como testimonio del Dios humanado que se abaja para mirarnos, amarnos en nuestras miserias, alimentarnos y reconciliarnos con nosotros mismos, con el Creador y con los otros.        La fidelidad al evangelio requiere una constante búsqueda de la voluntad de Dios; dejemos de obstaculizarnos y unamos fuerzas en la construcción del Reino; varón y mujer juntos formamos la imagen de Dios, ambos compartimos la misma dignidad y capacidad para asumir el llamado del Creador a la vida consagrada ministerial o laical dentro de la Iglesia.
Leer para creer
Authors: Fernández Márquez Fredy De jesus
Published: April 2017

Umberto Eco afirmó: «nadie acabará con los libros», en una época en la cual las nuevas tecnologías aparentemente extinguirán esa vieja usanza de la lectura del  papel, y de la lectura silenciosa como lo había enseñado San Ambrosio a uno de sus grandes discípulos como lo fue San Agustín. Por su lado, Santo Tomas de Aquino, otro  de los grandes baluartes de la iglesia en la filosofía del medioevo, afirmó: «Ver para creer», sentencia que deja claro que solo se debe dar crédito a lo que se ve directamente. Valga decir, dejar constancia de lo visible. Pero existen otras maneras de ver las cosas, como aquella de la lectura, en tanto que permite interpretar o deconstruir el cuerpo, la palabra, lo aparente, visibilizar lo oculto, mostrar lo posible, reconocer lo abstracto, filosofar sobre la vida, sentir las pasiones y los deseos, diría Spinoza a través del libro. A lo anterior,
Biomedical Applications of Nanomaterials as Therapeutics
Authors: Ng Cheng-Teng , Baeg Gyeong-Hun , Yu Liya E. , Ong Choon-Nam , Bay Boon-Huat
Published: April 2017

Background:

As nanomaterials possess attractive physicochemical properties, immense
research efforts have been channeled towards their development for biological and
biomedical applications. In particular, zinc nanomaterials (nZnOs) have shown great potential
for use in in the medical and pharmaceutical fields, and as tools for novel antimicrobial treatment,
thereby capitalizing on their unique antimicrobial effects.

Methods:

We conducted a literature search using databases to retrieve the relevant articles
related to the synthesis, properties and current applications of nZnOs in the diagnosis and
treatment of diseases. A total of 86 publications were selected for inclusion in this review.

Results:

Besides studies on the properties and the methodology for the synthesis of nZnOs,
many studies have focused on the application of nZnOs as delivery agents, biosensors and antimicrobial
agents, as well as in bioimaging.

Conclusion:

This review gives an overview of the current development of nZnOs for their
potential use as theranostic agents. However, more comprehensive studies are needed to better
assess the valuable contributions and the safety of nZnOs in nanomedicine.
Redes sociales de apoyo a la crianza de los menores en etapa escolar primaria
Authors: Roldán Ramírez Elvia Lucía , Ayala Carreño María Consuelo , Pérez Pineda Diana Patricia , Romero Dimaté Nancy Yolima
Published: April 2017

El estudio tuvo como propósito identificar la estructura y funcionalidad de las redes sociales de apoyo que tienen las familias para la crianza de sus hijos en etapa escolar primaria, a través de la caracterización de las familias y de las redes que les brindan algún tipo de soporte. Participaron 24 personas, 7 niños y niñas, entre los 7 y 11 años; 7 padres, madres y/o cuidadores entre los 20 y 60 años; 3 docentes; 2 orientadores escolares del Colegio Pablo de Tarso IED y 5 representantes de las instituciones que prestan servicios sociales a la comunidad en la localidad de Bosa. El enfoque de la investigación fue de tipo cualitativo y se aplicó a la muestra poblacional una entrevista semiestructurada. Los resultados muestran que existe un alto desconocimiento por parte de las familias acerca de los beneficios que ofrecen las instituciones, lo que impide que se generen interacciones, relaciones y una sinergia entre los nodos, es decir, la familia, el colegio y las instituciones que integran una red social de apoyo.
Características morfofuncionales y motoras de los seleccionados deportivos de la Universidad del Valle
Authors: Leiva Deantonio Jaime Humberto , Amú-Ruiz Francisco Antonio
Published: April 2017

Estamos convencidos de que el Sistema Nacional del Deporte estudiantil debe convertirse en el mejor instrumento para promover y articular la detección temprana de talentos, especializar la práctica y focalizar y priorizar la intervención estatal y privada en esta materia; igualmente, las decisiones de política deben privilegiar los procesos de perfeccionamiento, cualificación y competición de los mejores deportistas, hasta hacerlos parte del deporte asociado y de los calendarios deportivos, regionales, nacionales e internacionales. En tal sentido, se establecieron las características morfológicas, funcionales y motoras de los seleccionados de la Universidad del Valle, por deporte y sexo, como criterio para la selección, planeación de las cargas de trabajo y control del proceso de entrenamiento, de tal forma que se pueda garantizar la vinculación de los deportistas mejor dotados al sistema del deporte universitario y, por ende, al deporte asociado, con lo que se espera lograr una verdadera conexión que el país deportivo desconoce. Para el efecto, fueron valorados 125 deportistas de ambos géneros, 62,4 % hombres y 37,6 % mujeres, seleccionados al azar y pertenecientes a 12 modalidades que forman parte de los seleccionados de la universidad, según registro del Centro Deportivo Universitario (CDU). Los métodos empleados para el estudio fueron: las medidas antropométricas se establecieron mediante el método de ISAK, el porcentaje de grasa y el tejido magro estuvieron determinados por bioimpedancia, con el empleo de una báscula Tanita TBF-310, el tiempo de desplazamiento se midió mediante la carrera de 30 m salida parada, la potencia de miembros inferiores, con el test de Abalakov (ABK), la potencia aeróbica máxima, con el empleo del test de Leger y la agilidad, con el test de Illinois. En el análisis de componentes principales, cuatro factores explican el 89 % del total de la dispersión en mujeres, donde el primer factor se encuentra conformado por el porcentaje de grasa, el porcentaje de músculo y el tiempo para la distancia de 30 m; el segundo factor se relaciona con las longitudes y la masa corporal; el tercer factor, por la agilidad y el IMC; y el cuarto, por la potencia aeróbica máxima y la potencia anaeróbica aláctica. En el caso de los hombres se observa una mejor asociación entre los factores y las modalidades deportivas. El primer factor representa la masa y el porcentaje de músculo, asociados con deportes como atletismo, futsal y fútbol; un segundo factor recoge la potencia anaeróbica aláctica y la estatura y, finalmente, el tercer factor se asocia con la potencia aeróbica, la agilidad y el IMC. El análisis de medias no mostró diferencias significativas entre los deportes, excepto en la carrera de 30 m, motivo por el cual, se elaboraron tablas de calificación para las variables antropométricas y de condición física por género, uniendo en una sola las clasificaciones de los deportes individuales y colectivos.
Saneamiento básico: análisis de la relación entre gasto público y servicios a la población en ciudades brasileñas y peruanas
Authors: Silva da Rosa Fabricia , Díaz-Becerra Oscar A. , Lunkes Rogério João
Published: April 2017

Esta investigación tiene como objetivo analizar la relación entre gasto público y servicios a la población de saneamiento en ciudades brasileñas y peruanas. Para realizar el estudio se recogieron datos sobre agua, aguas residuales y residuos, en sus relaciones con el gasto público de 185 ciudades de Brasil y Perú, en el año 2014. Los datos fueron procesados mediante Data Envelopment Analysis (DEA), utilizando como datos de entrada el gasto en saneamiento y como datos de salida información sobre abastecimiento de agua potable, recolección de residuos y tratamiento de aguas residuales. Los resultados mostraron una falta de atención a la población de los tres elementos analizados, que pueden conducir a problemas sociales y ambientales. Por otra parte, no fue posible relacionar el gasto en saneamiento y servicios a la población, ya que las ciudades que gastan más (gasto per cápita) no revelan un alto nivel de servicio a la población. La falta de saneamiento puede estar relacionado con deficiencias en las políticas públicas y puede tener efectos externos negativos, como el trastorno de los entornos urbanos, temas de salud pública, la contaminación del Océano Atlántico (Brasil) y del Pacífico (Perú), la contaminación de las aguas subterráneas y de ríos que afectan tanto al medio ambiente como la población.
Marco general de análisis de la formación logística en Colombia
Authors: Ospina Díaz Milton Ricardo , Sanabria Rangel Pedro Emilio
Published: April 2017

Aquí se pretende realizar una revisión sobre la logística en Colombia que permita caracterizar su historia y desarrollo, entender su contexto actual y comprender la demanda formativa generada. También se hace un análisis de la oferta logística existente en el país en los diferentes niveles de formación. Se estudia la correspondencia entre los requerimientos sociales y las condiciones de la oferta académica en el campo. Con este fin se hace una revisión de la literatura internacional sobre el tema, para entender el estado global del campo que sirve de base para la discusión, y de la literatura nacional, con el fin de comprender la situación y contexto de Colombia, especialmente en el marco del posconflicto. Se revisaron documentos de organismos nacionales e internacionales, relacionados con el campo logístico, que alimentan la discusión al respecto. Posteriormente se realizaron síntesis y comparativos que permitieron construir el marco general para el estudio. Basado en ellos, se llevó a cabo una caracterización general de la logística, con énfasis en el caso colombiano, y un análisis del estado actual de la formación logística en el país. En general se encuentra que existe un sinnúmero de estudios nacionales e internacionales sobre el tema logístico, lo cual evidencia una preocupación creciente sobre este, y que tal interés se ha visto acompañado, en Colombia, por un crecimiento en el número de programas académicos en el campo, en los diferentes niveles de formación. No obstante, existen aspectos por revisar para las diferentes regiones y nuevos retos para la oferta formativa.
Análisis envolvente de datos para la medición de la eficiencia en instituciones de educación superior: una revisión del estado del arte
Authors: Buitrago Suescú Oscar Yecid , Espitia Cubillos Anny Astrid , Molano García Lisbeth
Published: April 2017

Este trabajo analiza los estudios más significativos a nivel mundial sobre medición de la eficiencia en instituciones de educación superior (IES), que para tal fin utilizan Análisis Envolvente de Datos. Para cada estudio se consideran las siguientes características: modelo seleccionado, orientación del modelo, entradas y salidas, resultados principales, conclusiones y empleo de algún método complementario. Se analizan estadísticamente los modelos y características estudiadas en las investigaciones citadas, destacando las pautas más usadas. Se espera que los resultados sean útiles para brindar una base a futuros investigadores sobre la forma de realizar la medición de eficiencia y el cálculo de índices de productividad, usando esta metodología según sus necesidades y requerimientos específicos. Se concluye que DEA se ha utilizado ampliamente para medir la eficiencia de la educación a nivel mundial, identificando 254 entradas y 230 salidas que para el análisis se agruparon en cuatro y tres categorías, respectivamente.
Alcances de los TLC firmados con Estados Unidos y Corea para las pequeñas y medianas empresas (pymes) en Colombia: un análisis del discurso
Authors: Yepes Lugo Cristian Armando , Ruiz Morato Natalia
Published: April 2017

El presente artículo analiza los diferentes discursos e identifica las posibles oportunidades y limitaciones que podrían enfrentar las pequeñas y medianas empresas (pymes) exportadoras colombianas en su dinámica de gestión organizacional en el contexto de liberalización económica a través de los TLC firmados por Colombia con Estados Unidos y con Corea del Sur. Además, se identifican los requisitos generales para exportar e importar bienes y servicios en esos intercambios comerciales con el objeto de determinar las posibilidades de acceso de Colombia a esos nuevos mercados. Los resultados surgen de un proceso de análisis del discurso de reportes de prensa y de agencias de gobierno relacionados con el contexto de estos tratados. Se encuentran amplias posibilidades a partir de los productos que se exportan tanto a Estados Unidos como a Corea del Sur; sin embargo, el panorama más difícil se observa en las pymes, las cuales, a pesar de haberse beneficiado de los grandes capitales que se movieron desde las grandes empresas dada la crisis de 1999, enfrentan enormes dificultades debido a su baja capacidad de gestión organizacional.