bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Relationship of Serum Cd163, Ykl40 and Vilip-1 Levels with Autism Severity and Language-Cognitive Development in Preschool Children with Autism
Authors: DEMİRCİ Samet Can , BARUN Süreyya , ÖZASLAN Ahmet , GÜLBAHAR Özlem , BULUT Tuba Saadet DEVECİ , ÇAMURDAN Aysu DUYAN , İŞERİ Elvan
Published: September 2023

This study aimed to compare serum levels of CD163, YKL-40, and VILIP-1 between children with autism spectrum disorder (ASD) and healthy controls, while also investigating their association with the severity of ASD and language development. The study included 40 ASD-diagnosed patients (aged 1–6 years) and 40 age-matched healthy controls. Childhood Autism Rating Scale (CARS), Preschool Language Scale-4 (PLS-4), and Ankara Development Screening İnventory (ADSI) were administered to children in the ASD group. Serum CD163, YKL-40 and VILIP-1 levels were measured with an enzyme-linked immunosorbent assay kit. In the ASD group compared to the control group, serum VILIP-1 levels were significantly higher (p = 0.046). No significant differences were observed in mean serum CD163 and YKL-40 levels between patients and controls (p = 0.613, p = 0.769). Interestingly, a positive correlation was observed between CD163 and YKL-40 levels and ASD severity (p < 0.001 for both). Additionally, CD163 and YKL-40 levels showed significant predictive value for ASD severity. While no significant associations were found between CD163 and YKL-40 levels and language development, a negative correlation was observed between VILIP-1 levels and language development (p < 0.001). Our findings highlight that the levels of CD163 and YKL-40 significantly predicted ASD severity, indicating a potential role of neuroinflammation in the development of ASD.
Utilization of Cross-Correlation Function for Assessment of Replication Quality in Ultrasonic Embossing of Microchannels on Polymethyl Methacrylate (PMMA)
Authors: Yildirim Ender , Ulku Mert Kerem , Arikan M.A. Sahir
Published: September 2023

Ultrasonic embossing is a promising method for fabricating microchannels on thermoplastics due to reduced cycle time and relatively low equipment cost. Replication quality in ultrasonic embossing has been investigated in the literature by primarily referring to the replication depth. However, this approach does not fully reflect the fidelity between the mold and the replicated feature, especially at the side walls, which are typically designed as vertical in microchannels. We propose to utilize cross-correlation between the gradients of the mold profile and the embossed profile as a figure of merit sensitive to the side wall’s fidelity. For testing purposes, we embossed straight microchannels on polymethyl methacrylate (PMMA) using a brass mold comprising 100, 300, and 1000 µm-wide protrusions of same designed height of 300 µm, resulting in aspect ratios (AR) of 3, 1, and 1/3, respectively. Cross-correlations between the gradients of the pofiles ranged between 0.50 and 1.00, while cross-correlations between the profiles were greater than 0.97 in all cases, showing the sensitivity imposed by utilizing the gradients. Setting average of all cross-correlation values (0.8) as the quality threshold, we observed that high AR (3) features were replicated at low quality, while low AR (1/3) features were replicated at high quality, regardless of the process parameters. In replicating unit AR features, the process parameters were observed to affect the quality, where the combination of vibration time and pressure was the most significant compared to individual effects of the parameters.
Comparing Video Laryngoscopy and Direct Laryngoscopy for Tracheal Intubation in Critically Ill Adults: A Comprehensive Updated Meta-Analysis and Systematic Review
Authors: Azam •	Saad , Kha •	Zainab Zaib , Siddiqui •	Aisha , Masood •	Natasha , •	Anum  , Ahmed •	Usman , Arif •	Yumna , Memon •	Zeenat Umair , Khawar •	Muhammad Hasnain , Siddiqui •	Farina Fatima
Published: September 2023

Background: Direct laryngoscopy was the modality used in successful trachea intubation. With the advancements in science, video laryngoscopy was introduced to conduct the same procedures with enhancements in viewing glottic views. In emergency settings, both laryngoscopes are commonly used for intubations. This study compares which is more successful in first-attempt tracheal intubation in critically ill patients.
Materials and methods: The PubMed database was thoroughly searched for this systematic review and meta-analysis. All RCTs and Observational studies until 2023 were included, whose primary outcome was the first attempt at successful tracheal intubation. The secondary outcomes were severe hypoxemia, severe hypotension, and cardiac arrest.
Results: In emergency situations, the success rate of intubation on the first attempt was significantly higher in video laryngoscopy than in direct laryngoscopy. The risk ratio was 1.19 (95% CI 1.10 to 1.29) with a heterogeneity of I2 = 75%. However, there was no significant correlation found between video laryngoscopy and severe hypoxemia, severe hypotension, or cardiac events. The risk ratio for severe hypoxemia was 0.99 (95% CI 0.74 to 1.33), for severe hypotension was 0.19 (95% CI 0.83 to 1.72), and for cardiac events, the risk ratio was 1.17 (95% CI 0.37 to 3.70). The P value was non-significant for these secondary outcomes, indicating that these complications were not associated with video laryngoscopy. The heterogeneity among the secondary outcomes was much lower than that of the primary outcome. It's important to note that there was substantial heterogeneity among the outcomes.
Conclusion; our updated meta-analysis has confirmed that video laryngoscopy (VL) has a higher success rate for first-pass intubation than direct laryngoscopy (DL). As a result, we recommend using VL over DL for critically ill patients. Furthermore, our analysis has shown no significant evidence linking VL to any adverse events.
Trends in Consumer Preferences for Product Customization and their Application in Product Design
Authors: Powell Carter , Yang Sheng
Published: September 2023

Consumer preferences play an important role in the decision to customize a product. The collection of consumer preferences can be a challenging task and most methods require significant effort while only focusing on one specific product or product type. A popular method of collecting consumer preferences is a survey as it is easy to administer and can be tailored to gather specific desirable information. In this paper, a survey is developed to gather consumer preferences for product customization with a focus on identifying trends amongst these preferences. User preferences are correlated to factors of success in customization and categorical definitions of product attributes. Twenty-five products were evaluated, with one hundred total responses collected. The results show the existence of product clusters that represent trends amongst consumer preferences for customization. The trends and clusters identified have potential applications in the design of novel customized products by using categorical representations to generalize the findings. This method of generalization can provide cost and time savings in the product design cycle for future customized products by reducing the effort required to elicit consumer preferences.
Water and Nitrate‐Nitrogen Losses From a Small, Upland, Coastal Plain Watershed
Authors: Hubbard R. K. , Sheridan J. M.
Published: September 2023

Surface runoff (SRO) and shallow‐subsurface flow (SSF) from a small, upland, Coastal Plain watershed underlain by plinthite were monitored for a 10‐y period. Samples collected during surface runoff and subsurface‐flow events were analyzed for NO3‐N. The major water runoff loss from the system was found to be subsurface flow, accounting for 79% of total runoff loss, which occurred primarily from December through May. Nitrate‐N concentrations in surface runoff and subsurface flow were relatively uniform over the period, averaging 0.47 and 8.75 mg/L, respectively. The combination of high volume of subsurface flow and its relatively high NO3‐N content, resulted in 99% of total NO3‐N loss via subsurface flow. Predictive equations for monthly surface and subsurface water runoff losses from this watershed were developed using multiple linear regression. The equations contain seasonal and climatic parameters, including pan evaporation. Tests of the equations with observed results gave significant (P ≤ 0.01) correlation coefficients, r, of 0.82 and 0.85 for surface runoff and subsurface flow, respectively. Mean surface and subsurface NO3‐N concentrations were multiplied by predicted monthly flows to compute predicted monthly NO3‐N losses. Comparison of predicted and actual monthly NO3‐N losses gave significant (P ≤ 0.01) correlation coefficients, r, of 0.59 and 0.86 for surface and subsurface flows, respectively. The good fit of predicted and observed results can be partially attributed to the seasonal and climatic data base collected over a relatively long period of 10 y.
Risk Perception, Risk Communication, and Stakeholder Involvement for Biosolids Management and Research
Authors: Beecher Ned , Harrison Ellen , Goldstein Nora , McDaniel Mary , Field Patrick , Susskind Lawrence
Published: September 2023

An individual's perception of risk develops from his or her values, beliefs, and experiences. Social scientists have identified factors that affect perceptions of risk, such as whether the risk is knowable (uncertainty), voluntary (can the individual control exposure?), and equitable (how fairly is the risk distributed?). There are measurable differences in how technical experts and citizen stakeholders define and assess risk. Citizen knowledge and technical expertise are both relevant to assessing risk; thus, the 2002 National Research Council panel on biosolids recommended stakeholder involvement in biosolids risk assessments. A survey in 2002 identified some of the factors that influence an individual's perception of the risks involved in a neighbor's use of biosolids. Risk communication was developed to address the gap between experts and the public in knowledge of technical topics. Biosolids management and research may benefit from applications of current risk communication theory that emphasizes (i) two‐way communications (dialogue); (ii) that the public has useful knowledge and concerns that need to be acknowledged; and (iii) that what may matter most is the credibility of the purveyor of information and the levels of trustworthiness, fairness, and respect that he or she (or the organization) demonstrates, which can require cultural change. Initial experiences in applying the dialogue and cultural change stages of risk communication theory—as well as consensus‐building and joint fact‐finding—to biosolids research suggest that future research outcomes can be made more useful to decision‐makers and more credible to the broader public. Sharing control of the research process with diverse stakeholders can make research more focused, relevant, and widely understood.
Evaluating Livestock System Environmental Performance with Whole‐Farm Nutrient Balance
Authors: Koelsch Rick
Published: September 2023

As a part of the USEPA's concentrated animal feeding operation (CAFO) final rule, all CAFOs are required to develop and implement a nutrient management plan (NMP). The USEPA's emphasis on better management of nutrients appropriately targets a critical environmental issue associated with animal production. The concentration of animals in livestock feeding operations, often separate from feed grain production, requires importing of substantial quantities of feed nutrients. Due to the inefficiencies of nutrient utilization in livestock production, quantities of nitrogen (N) and phosphorus (P) in manure greater than can be utilized in local crop production often result. With the focus of the USEPA's NMP rules on internal farm manure management planning, nutrient concentrations resulting from animal concentration may not be adequately addressed by compliance with the USEPA rules alone. A review of two mandatory and two voluntary nutrient management strategies is made by comparing whole‐farm nutrient balance for a case‐study beef cattle feedlot. The results suggest that voluntary BMPs, such as modification to animal feeding program and exporting of manure, can have greater environmental benefits (30–60% reduction in P accumulation for case‐study farm) than mandatory NMPs and buffers (5–7% reduction in P accumulation for case‐study farm) for a typical beef cattle feedlot. Whole‐farm nutrient balance procedures can also be valuable for reviewing the nutrient performance of livestock systems.
Bacterial Diversity in Selenium Reduction of Agricultural Drainage Water Amended with Rice Straw
Authors: Siddique Tariq , Okeke Benedict C. , Zhang Yiqiang , Arshad Muhammad , Han Suk K. , Frankenberger William T.
Published: September 2023

Bacterial reduction of the Se oxyanions selenate [Se(VI)] and selenite [Se(IV)] to elemental selenium [Se(0)] is an important biological process in removing Se from drainage water. This study was conducted to characterize the molecular diversity of bacterial populations involved in Se reduction of drainage water amended with rice (Oryza sativa L.) straw and also to monitor the bacterial community shifts during the course of the study. Selenate was removed in the drainage water by the bacteria 5 to 6 d after addition of rice straw. Six Se(VI)‐ and 32 Se(IV)‐reducing bacteria were isolated from rice straw containing sterilized drainage water. Three Se(VI)‐ and two Se(IV)‐reducing bacteria were also isolated from the drainage water. Identification of Se(VI)‐ and Se(IV)‐reducing bacteria by 16S rDNA sequence analysis showed a broad phylogenetic diversity in Se‐reducing assemblages. Three major phyla (Proteobacteria, Actinobacteria, and Firmicutes) of bacterial domain with numerous classes, orders, and families constituted the Se‐reducing bacterial community. We documented changes in the composition of bacterial assemblages in the drainage water amended with rice straw using polymerase chain reaction (PCR)–denaturing gradient gel electrophoresis (DGGE) of 16S rDNA. The Shannon–Weaver index (H′) revealed higher bacterial diversity at Day 6 in the sterilized and Day 4 in the nonsterilized drainage water amended with rice straw. The results of this study suggest that rice straw, a good source of carbon and energy, harbors a wide range of bacteria useful in Se reduction and may be used in removing Se from drainage water.
Tillage Erosion and Its Effect on Soil Properties and Crop Yield in Denmark
Authors: Heckrath G. , Djurhuus J. , Quine T. A. , Van Oost K. , Govers G. , Zhang Y.
Published: September 2023

Tillage erosion had been identified as a major process of soil redistribution on sloping arable land. The objectives of our study were to investigate the extent of tillage erosion and its effect on soil quality and productivity under Danish conditions. Soil samples were collected to a 0.45‐m depth on a regular grid from a 1.9‐ha site and analyzed for137Cs inventories, as a measure of soil redistribution, soil texture, soil organic carbon (SOC) contents, and phosphorus (P) contents. Grain yield was determined at the same sampling points. Substantial soil redistribution had occurred during the past decades, mainly due to tillage. Average tillage erosion rates of 2.7 kg m−2yr−1occurred on the shoulderslopes, while deposition amounted to 1.2 kg m−2yr−1on foot‐ and toeslopes. The pattern of soil redistribution could not be explained by water erosion. Soil organic carbon and P contents in soil profiles increased from the shoulder‐ toward the toeslopes. Tillage translocation rates were strongly correlated with SOC contents, A‐horizon depth, and P contents. Thus, tillage erosion had led to truncated soils on shoulderslopes and deep, colluvial soils on the foot‐ and toeslopes, substantially affecting within‐field variability of soil properties. We concluded that tillage erosion has important implications for SOC dynamics on hummocky land and increases the risk for nutrient losses by overland flow and leaching. Despite the occurrence of deep soils across the study area, evidence suggested that crop productivity was affected by tillage‐induced soil redistribution. However, tillage erosion effects on crop yield were confounded by topography–yield relationships.
Atrazine Sorption–Desorption Hysteresis by Sugarcane Mulch Residue
Authors: Selim H. M. , Zhu H.
Published: September 2023

Sorption and desorption kinetics are essential components for modeling the movement and retention of applied agricultural chemicals in soils and the fraction of chemicals susceptible to runoff. In this study, we investigated the retention characteristics of sugarcane (Saccharum spp. hybrid) mulch residue for atrazine (2‐chloro‐4‐ethylamino‐6‐isopropylamino‐1,3,5‐triazine) based on studies of sorption–desorption kinetics. A sorption kinetic batch method was used to quantify retention of the mulch residue for a wide range of atrazine concentrations and reaction times. Desorption was performed following 504 h of sorption using successive dilutions, followed by methanol extraction. Atrazine retention by the mulch residue was well described using a linear model where the partitioning coefficient (Kd) increased with reaction time from 10.40 to 23.4 cm3 g−1 after 2 and 504 h, respectively. Values for mulch residue Kd were an order of magnitude higher than those found for Commerce silt loam (fine‐silty, mixed, superactive, nonacid, thermic Fluvaquentic Endoaquepts) where the sugarcane crop was grown. A kinetic multireaction model was successful in describing sorption behavior with reaction time. The model was equally successful in describing observed hysteretic atrazine behavior during desorption for all input concentrations. The model was concentration independent where one set of model parameters, which was derived from all batch results, was valid for the entire atrazine concentration range. Average atrazine recovery following six successive desorption steps were 63.67 ± 4.38% of the amount adsorbed. Moreover, a hysteresis coefficient based on the difference in the area between sorption and desorption isotherms was capable of quantifying hysteresis of desorption isotherms.
Phosphorus Leaching in Manure‐Amended Atlantic Coastal Plain Soils
Authors: Butler Jennifer S. , Coale Frank J.
Published: September 2023

Targeting the sources of phosphorus (P) and transport pathways of drainage from agricultural land will assist in the reduction of P loading to surface waters. Our research investigated the vertical movement of P from dairy manure and broiler litter through four Atlantic Coastal Plain soils. A randomized split‐plot design with two main‐plot tillage treatments (no tillage [NT] and chisel tillage [CH]) and five manure P rate split‐plot treatments was used at each location. The split‐plot P rates were 0, 100, 200, 300, and 400 kg P ha−1 yr−1 Four consecutive years of manure application began at all sites 5 yr before sampling. Soils were sampled to a depth of 150 cm from each split plot in seven depth increments and analyzed for soil test phosphorus (STP), water‐extractable soil phosphorus (WSP), and degree of phosphorus saturation (DPS). The DPS of the 0‐ to 15‐cm depths confirmed that at the 100 kg P ha−1 yr−1 application rate, all sites exceeded the threshold for P saturation (30%). At depths greater than 30 cm, DPS was typically below the 30% saturation threshold. The DPS change points ranged from 25 to 34% for the 0‐ to 90‐cm depths. Our research concluded that the risk of P leaching through the matrix of the Atlantic Coastal Plain soils studied was not high; however, P leaching via macropore bypass may contribute to P loss from these soils.
Co-creation experience in Indonesian mobile commerce: A self-determination theory perspective
Authors: Iqbal Firdaus Muhammad , A. Utama Cynthia , Gayatri Gita , Rofianto Whony
Published: September 2023

Understanding customer co-creation experience in mobile commerce helps business to tailor their offerings, improves customer engagement, and cultivates long-lasting brand relationships, ultimately leading to business success in the competitive digital marketplace. Anchoring in service-dominant logic and self-determination theory framework, this study aims to investigate customers’ internal stimuli as the antecedents of the co-creation experience and its impact on brand relationship behavior. An online survey was employed to gather data from 499 users of Shopee, Tokopedia, Bukalapak, and Lazada mobile commerce marketplaces in Indonesia. PLS-SEM is used to analyze the conceptual model. The results reveal that customers’ internal stimuli of enabling the self and gratifying the self positively influence the co-creation experience (t-value > 1.645, p-value < 0.001). At the same time, no significant effect was found on the relationship between enriching the self and the co-creation experience. This study also confirms the role of co-creation experience in motivating continuance intention and E-WOM (t-value > 1.645, p-value < 0.001). The findings contribute to developing and validating the co-creation experience concept by demonstrating the role of customer internal stimuli in influencing the co-creation experience, thus motivating customer continuance intention and E-WOM behavior. The findings suggest the importance of the focus given by mobile commerce marketplace managers in designing mobile commerce platforms that can also meet the inner needs of users. A positive co-creation experience can enhance customer commitment and thus encourage positive E-WOM. These factors contribute to the long-term success and growth of mobile commerce platforms in an increasingly competitive market.
Electro-erosion fault identification of motor bearing based on ASMOTE-CFR
Authors: Cheng Huan Ke
Published: September 2023

In view of the problem that the electro-erosion fault signal is rare and weak during motor operation, and the database is seriously imbalanced, this paper proposes an ASMOTE-CFR training model based on adaptive minority oversampling technology. Four bearing vibration acceleration signals in different states were collected through experiments, and each signal obtained 32 sets of energy features using wavelet packet decomposition. Then ASMOTE technology is used to balance the energy features of electro-erosion fault signal. And construct a vector matrix combined by energy features and bearing fault state features. Finally, the collaborative filter model of matrix decomposition is used to train and identify. The results show that the recognition rate of the ASMOTE-CFR model proposed in this paper is 98.46 %, which improves by 7 % compared with the traditional CFR, which verifies the effectiveness of this method.
Fault diagnosis method for hydro-power plants with Bi-LSTM knowledge graph aided by attention scheme
Authors: Guo Bilei , Wang Yining , Pan Weifeng , Sun Yanlin
Published: September 2023

In hydro-power systems, the fault of equipment is an important potential threat for the safe production of electricity. Therefore, the automation and intelligence of fault diagnosis becomes the popular issue in the research on hydro-power system. In this paper, a knowledge graph-based method is put forth to diagnose faults occurred in hydro-power systems, since the knowledge graph can store structured and unstructured data for better fault diagnosis and intelligently search the reasons of the faults. First, we model the knowledge graph for hydro-power plants, where the rational path for the fault reason is formulated. Then, the bi-directional long short-term memory (Bi-LSTM) with conditional random field (CRF) is used to extract the entities and relations to the given documents, which record the phenomenon and reasons for the occurred faults. Moreover, the attention scheme is employed in the Bi-LSTM to weigh the closer relationships to improve the diagnosis accuracy. An automatic diagnosis algorithm is developed to improve the diagnosing efficiency by constructing rational paths, with which directive and in-directive factors for occurring faults can be traced. Simulation results reveal that the intelligent search method with a knowledge graph can effectively find the reason, locate the position, and provide useful suggestions for the occurred faults.
SEMANTIC AND PRAGMATIC FEATURES OF OBVIOUSLY AND APPARENTLY
Authors: Šajinović Novaković Jelena , Muhić Emir Z.
Published: September 2023

In this paper we are going to show how disjuncts obviously and apparently from the same category of truth-orientated disjuncts behave in different contexts. We are also going to measure the frequency of their occurrence, determine the meanings they convey and observe the position they take. Both disjuncts ‘present comment on the truth value of what is said, expressing the extent to which, and the conditions under which, the speaker believes that what is saying is true' (Quirk et al, 1985:p.620). The primary function of these two is to modify the whole sentence, but they can also highlight the meaning of the modal expression they are used with. The comment expressed by obviously does not intend to convince the interlocutor to trust the speaker's judgement but to act as an eye-opener for interlocutors to discern the truth themselves based on the evidence given. The comment expressed by apparently relies either on speaker's perception of things or someone else's perception which is not to be believed blindly without questioning. In other words, apparently ’qualifies claims based on reported information and inference' (Rozumko, 2019). Hence conviction expressed by it drifts from the truth conveying a certain degree of doubt.
FORSTER’S ITALIAN NOVELS AS A TESTGROUND FOR A PASSAGE TO INDIA
Authors: Crnogorac Branko Č.
Published: September 2023

M. Forster is one of the authors whose auto-referentiality manifests itself on several levels, from the choice of themes regarding his novels and short stories, over his styllistic features, leitmotifs, symbols, and clear social engagement with concern to major global issues, to the transtextuality of his characters as, probably, the most outstanding one.

Through the prism of some key notions of colonial/postcolonial discourse, the paper deals with Forster's 'Italian novels' (A Room with a View and Where Angels Fear to Tread) as a testground for some of the themes and motifs elaborated in A Passage to India.
LANGUAGE AND GENDER – MALE AND FEMALE LANGUAGE PATTERNS IN THE GREEK SERIES MHN APXIZEIΣ THN MOYPMOYPA
Authors: Baćić Ćosić Maja G.
Published: September 2023

Television is a dominant medium that can influence one’s attitude and social ideologies formation since it reflects sociolinguistic reality and maintains language ideologies and existing social stereotypes. For that reason, we can mention so-called female and male language patterns and their main characteristics, which are to a great extent associated with social power, i.e. the role that an individual has in his social community or community of practice. This paper aims to examine whether the Greek media and more specifically, the Greek TV series promote so-called male and female language patterns, as well as social stereotypes directed towards women. In this paper, we analysed the linguistic behaviour of the protagonists of the Greek series Mην αρχίζεις την μουρμούρα. Qualitative non-experimental research based on the analysis of linguistic behaviour at the level of the characters‘ lexical choice, Vaso and Charis showed that their choice of language patterns is proportional to their social or professional status. In addition, we noticed the presence of certain social stereotypes, while it is evident that the use of stereotypical-female language patterns is associated with a hierarchically lower social position.
CHRONICLES OF HARDSHIPS OF THE SERBIAN LANGUAGE ON THE TERRITORY OF KOSOVO AND METOHIJA: A LIVING TESTIMONY OF SUFFERING AND FAITH
Authors: Црњак Дијана
Published: September 2023

Приказ
ON THE BOOK OF PROCEEDINGS IN HONOUR OF PROF. MIRKO SKAKIĆ, PHD
Authors: Раца Јелена Д.
Published: September 2023

Приказ
Liuwei Dihuang Prevents Human Umbilical Vein Endothelial Cells Senescence via the JPX-STING-IRF3 Pathway
Authors: Xu Chao , Cai Tiantian , Du Xinghai
Published: September 2023

Background:

Cellular senescence plays a crucial role in age-related diseases. Endothelial senescence is closely associated with age-related vascular disorders. This study aimed to reveal the role of traditional Chinese medicine Liuwei Dihuang (LWDH) in anti-endothelial cell senescence.

Methods:

Human umbilical vein endothelial cells (HUVECs) were exposed to LPS treatment to induce senescence. Senescence-associated β-galactosidase (SA-β-gal) positive staining, p53 and p16 expression, BrdU staining, and relative telomere length (RTL) experiments were conducted to estimate LPS-induced cellular senescence of HUVECs. Real-time qPCR analysis was performed to identify differentially expressed lncRNAs in LPS-induced senescent HUVECs before and after treatment with LWDH. Bioinformatics analysis and ChIP assay were conducted to explore the mechanism of JPX in the anti-endothelial cell aging effect of LWDH.

Results:

We first discovered that lncRNA JPX and STING-IRF3 pathways are involved in the process of anti-endothelial senescence of LWDH. Mechanistically, LWDH could reverse abnormally elevated JPX induced by LPS and inhibit the activation of STING, as well as the interaction between JPX and STING.

Conclusion:

Overall, our study explores the potential therapeutic value of LWDH and provides key insights into the potential avenues for preventing and treating HUVECs senescence.
WITHDRAWN: Extraction, Characterization and Controlled Release Application of Pectin-like/chitosan Hydrogels System loaded Ciprofloxacin
Authors: Hameed Amer Rashid , Mzoughi Zeineb , Dammak Mariem Itaimi , Jabrail Fawzi Habeeb , Le Cerf Didier , Majdoub Hatem
Published: September 2023

Since the authors are not responding to the editor’s requests to fulfill the editorial requirement, therefore, the article has been
withdrawn.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

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Naphthoquinone Derivatives Targeting Melanoma
Authors: Nunes Jéssica Alves , da Silva Nunes Adrielle Firmino , da Paz Lima Dimas José , da Silva-Júnior Edeildo Ferreira
Published: September 2023

Cancer is responsible for high mortality rates worldwide, representing a serious health
problem. In this sense, melanoma corresponds to the most aggressive type of skin cancer, being the
cause of the highest death rates. Therapeutic strategies for the treatment of melanoma remain limited,
with problems associated with toxicity, serious side effects, and mechanisms of resistance. The
potential of natural products for the prevention and treatment of melanoma has been reported in different
studies. Among these compounds, naphthoquinones (1,2-naphthoquinones and 1,4-naphthoquinones)
stand out for their diverse pharmacological properties, including their antitumor activity.
Thus, this review covers different studies found in the literature on the application of natural naphthoquinones
targeting melanoma, providing information regarding the mechanisms of action investigated
for these compounds. Finally, we believe that this review provides a comprehensive basis
for the use of natural naphthoquinones against melanoma and that it may contribute to the discovery
of promising compounds, specifically naphthoquinones, aimed at the treatment of this cancer.
Role of Vitamin D in Management of Diabetes and Unresolved Cardiovascular
Diseases
Authors: Upadhyay Prabhat Kumar , Thakur Navneet , Vishwakarma Vishal Kumar , Srivastav Ritesh Kumar , Ansari Tarique Mahmood
Published: September 2023

Background:

Vitamin D deficiency is becoming a widely recognized global health issue.
Serum values of 25(OH) vitamin D (<20 ng/ml) are used to identify vitamin D deficiency. By
prompting vascular endothelial cells to activate their nuclear receptor in cardio-myocytes, Vitamin
D regulates obesity, Renin-angiotensin system (RAS), energy consumption, and pancreatic cell
function. Vitamin D deficiency has been associated with diabetes, asthma, hyperlipidaemia, and
pulmonary hypertension in humans.

Methods:

PubMed and Google Scholar databases were utilised to search the literature on vitamin
D and related diseases.

Result:

It is also linked to an elevated risk of death and heart disease. On the other hand, metaanalyses
of vitamin D intervention and trials have found no substantial changes in insulin sensitivity,
lipid markers, or blood pressure, which result in the association between deficiency of vitamin
D and cardiovascular disease.

Conclusion:

In this review, we present the most recent research on the effects of Vitamin D therapy
on various cardiovascular diseases and diabetes, and explain the underlying mechanisms.
The Intersection between Alcohol use and Sexual Activity among Young Adult Male U.S. Service Members
Authors: Orchowski Lindsay M. , Meerhaeghe Bryce M , Lane Amber R. , Kazemi Donna M. , Borsari Brian , Berry-Cabán Cristóbal S.
Published: September 2023

Aims:

The current study explores drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior among young adult male active duty service members in the United States.

Background:

Hazardous alcohol use is a significant problem among United States military service members. Whereas the association between alcohol use and sexual assault is well documented in civilian samples, less is known regarding the intersection of alcohol use and sexual activity among soldiers.

Objective:

Descriptive statistics were utilized to summarize drinking habits, preferences for alcohol use before sexual activity, and alcohol-related sexual behavior.

Methods:

A sample of 338 active-duty male service members between the ages of 18 and 24 were recruited from a large military post in the Southeastern United States. Constructs were assessed using self-report surveys.

Results:

Participants reported consuming alcohol, on average, 5.6 times over the prior month. Average alcohol consumption was reported to be 7.8 beverages per drinking occasion. Participants reported engaging in heavy drinking an average of 2.9 times over the past 30 days. On average, service members reported a preference for 1.3 drinks before sexual activity. Furthermore, 75.2% of participants preferred to be sober during sex, and 82.1% preferred to engage in sexual activity with a sober partner. Approximately 14% of the sample reported using alcohol to improve their chances of having sex.

Conclusion:

These findings highlight high rates of alcohol use among soldiers. Nonetheless, young adult male soldiers report a preference for sexual activity while sober. Understanding the co-occurrence of alcohol use and sexual activity has the potential to inform the development of integrated alcohol and sexual assault prevention programs for service members.
Latex Allergy – From Discovery to Component-resolved Diagnosis
Authors: Loverre Teresa , Casella Rossella , Miniello Andrea , Di Bona Danilo , Nettis Eustachio
Published: September 2023

Latex allergy is a hypersensitivity response to natural rubber latex (NRL) proteins or rubber chemicals used in the manufacture of latex products. An accurate diagnosis is the first step in the effective management of individuals with latex allergy, especially in high-risk groups, such as healthcare workers and those affected by spina bifida. Diagnosis is based on the clinical history and an accurate allergological evaluation. In the case of type I IgE-mediated hypersensitivity reac-tions, which can manifest urticaria, angioedema, rhinoconjunctivitis, asthma and anaphylaxis after latex exposure, skin prick tests or latex-specific IgE (sIgE) antibody detection using serological assays can be performed to confirm sensitization. Instead, in the case of contact dermatitis, a patch test can be applied to confirm the presence of a type IV T cell-mediated hypersensitivity reaction to rubber accelerators or additives. Basophils activation tests or challenge tests may be performed if there’s an incongruity between the clinical history and the results of in vivo and in vitro tests. The aim of this review is to analyze the current state of the art of diagnostic techniques for latex allergy and algorithms employed in clinical practice and possible future developments in this field.
Terpenoids in Diabetic Nephropathy: Advances and Therapeutic
Opportunities
Authors: Kaushik Manish , Kaushik Aditi , Chaudhary Jasmine , Jain Akash
Published: September 2023

Diabetic nephropathy (DN) is the foremost ailment resulting in end-stage renal damage. Chronic hyperglycaemia and hyperlipidaemia are the foremost reason for disease progression. The dis-ease is characterized by the severity of albuminuria and cardiovascular disorders. Approximately 20 to 40% of the global prevalence of DN is mostly reported to occur in individuals with diabetes, and nearly 28% of DN occurs in individuals with other renal disorders. The pathological mechanism is very com-plex, involving innumerable targets and leading to multiple pharmacological effects. Thus, the scien-tific community is forced to work in search of safe and potent therapeutics that can tackle the complex pathology of DN effectively. The secondary plant metabolites categorized as terpenoids gained atten-tion as potential therapeutics contrary to others for the management of diabetic nephropathy and other associated syndromes by their strong antioxidant activity and inhibition of advanced glycation and its associated products. This review focused on herbal therapeutics for the management of diabetic nephropathy. Moreover, different types of terpenoids, their biological sources, and proposed mecha-nisms of action are explored for the development of a novel pharmacophore for diabetic nephropathy.
An Overview of Metallic Nanoparticles: Classification, Synthesis,
Applications, and their Patents
Authors: Dhir Sarika , Bhatt Shailendra , Chauhan Mahima , Garg Vandana , Dutt Rohit , Verma Ravinder
Published: September 2023

Background:

Nanotechnology has gained enormous attention in pharmaceutical research.
Nanotechnology is used in the development of nanoparticles with sizes ranging from 1-100 nm, with
several extraordinary features. Metallic nanoparticles (MNPs) are used in various areas, such as molecular
biology, biosensors, bio imaging, biomedical devices, diagnosis, pharmaceuticals, etc., for their specific
applications.

Methodology:

For this study, we have performed a systematic search and screening of the literature and
identified the articles and patents focusing on various physical, chemical, and biological methods for the
synthesis of metal nanoparticles and their pharmaceutical applications.

Results:

A total of 174 references have been included in this present review, of which 23 references for
recent patents were included. Then, 29 papers were shortlisted to describe the advantages, disadvantages,
and physical and chemical methods for their synthesis, and 28 articles were selected to provide
the data for biological methods for the formulation of metal NPs from bacteria, algae, fungi, and
plants with their extensive synthetic procedures. Moreover, 27 articles outlined various clinical applications
of metal NPs due to their antimicrobial and anticancer activities and their use in drug delivery.

Conclusion:

Several reviews are available on the synthesis of metal nanoparticles and their pharmaceutical
applications. However, this review provides updated research data along with the various methods
employed for their development. It also summarizes their various advantages and clinical applications
(anticancer, antimicrobial drug delivery, and many others) for various phytoconstituents. The overview
of earlier patents by several scientists in the arena of metallic nanoparticle preparation and formulation
is also presented. This review will be helpful in increasing the current knowledge and will also inspire
to innovation of nanoparticles for the precise and targeted delivery of phytoconstituents for the treatment
of several diseases.
Comparing the Effectiveness and Safety of Anterior Cervical Discectomy and Fusion with Four Different Fixation Systems: A Systematic Review and Network Meta-analysis
Authors: Xiao Jin , Yu Hui , Sun Jianfeng , Deng Yuxuan , Zhao Yang , Gao Rui , Li Xian
Published: September 2023

Background:

Anterior cervical discectomy and fusion (ACDF) is the classic procedure for the treatment of degenerative cervical myelopathy (DCM). Cage with plate (CP), polyetheretherketone cage alone (PCA), ROI-C and Zero-P are the most widely used fixation systems in ACDF. However, there is insufficient evidence to determine the optimal system for ACDF.

Purpose:

A comprehensive analysis to show which of the CP, PCA, ROI-C and Zero-P after ACDF has the best clinical efficacy and the most reliable safety.

Methods:

We searched the Embase, Pubmed, and Cochrane library up to the date of February 13th, 2021. Studies included relevant randomized controlled trials (RCTs) and cohort studies with a comparison of different fixation systems among CP, PCA, ROI-C and Zero-P were identified.

Results:

We screened 43 trials eligible, including 3045 patients. No significant differences were found in the NDI score. PCA has shown a significantly less recovery of cervical lordosis than CP and Zero-P. For the non-fusion rate, PCA was significantly higher than CP. PCA had a significantly higher subsidence rate than CP and Zero-P, and ROI-C was also significantly higher than CP. For the incidence of complications, CP was significantly higher than the others. The surface under the cumulative ranking curves (SUCRA) for NDI score improvement was: SSC, PCA, and CP. ROI-C, Zero-P, PCA, and CP; for cervical lordosis recovery: CP, Zero-P, ROI-C, and PCA; for non-fusion rate: PCA, Zero-P, ROI-C, and CP; for subsidence rate: PCA, ROI-C, Zero-P, and CP; for complications: CP, PCA, ROI-C, and Zero-P.

Conclusion:

Despite the third-ranking spectrums of fusion rate, Zero-P still could be recommended for its second-ranking spectrums of the NDI score improvement efficacy, cervical lordosis recovery, and reduction of subsidence rate, with the least ranking of complications.

Registration:

The number of PROSPERO is CRD42021230735 (www.crd.york.ac.uk/PROSPERO).
Investigation into Factors Affecting Penetration Rate and Favorable Ground Types of Pipe Jacking
Authors: Hosny Suad , El-Demerdash Ahmed , El-Kelesh Adel M.
Published: September 2023

Introduction:

Improper assessment of the penetration rate (PR) of pipe jacking (PJ) may lead to serious schedule delays and cost overruns. In the current practice, PR is estimated on the basis of the experience of practitioners. This has resulted in predicted PR values that are not consistent with the actual ones. A guideline that can be used to reliably predict PR and account for the effects of the significantly controlling factors is not available. This negatively affects the estimated project time and cost. The problems stem from the many factors that affect PR such as the ground conditions, installation depth, machine type, operator experience, and pipe diameter. Little research has been made in this regard. So this research will focus on two main objectives; the first is to identify, categorize and rank the factors that affect PR, and the second is to investigate the common types of ground and PJ machines in Egypt and the Middle East to determine the favorable ground types for PJ machines.

Methods:

To determine the factors that affect the PR of PJ and their relative importance, interviews were made with 17 PJ experts in Egypt. Then, a questionnaire was sent to 149 PJ experts in Egypt and the Middle East. The obtained responses were analyzed and the relative importance of all factors was determined. Based on the interviews with experts and the questionnaire survey, the favorability of ground types for the slurry and auger machines was determined.

Results:

The responses and analysis results of the interviews and questionnaire are weighted using the relative importance method and then ranked. The analysis reveals that 20 factors significantly affect PR. The top 5 factors that affect PR are 'ground type', 'ground condition', 'geotechnical investigation', 'crew/operator experience', and 'pipe lubrication'.

Conclusion:

Among the ten new factors which are introduced in this study, the four factors 'ground type', 'ground settlement', 'bentonite water ratio', and 'feed flow rate' are assessed as significant and ranked as the 1st, 7th, 16th, and 20th most important, respectively. It is also concluded that sand and silty sand are very highly favorable for the slurry machines, while silty clay is very highly favorable for the auger machines.
Mining Roles Based on User Dynamic Operation Logs
Authors: Ma Xiaopu , Qi Qinglei , Zhao Li , Ning Fei , Li He
Published: September 2023

Background:

If we rely solely on whether to assign permissions together to determine roles, the roles we generate may not necessarily reflect the needs of the system. Therefore, the role generation process can be done based on user-to-permission dynamic relationships, such as user dynamic operation logs, thus providing the motivation for this work.

Methods:

In our paper, we introduce a special generalization process and a frequent set-based analysis method to generate roles based on the particular data type of user dynamic operation logs so that the time factor of permissions used is considered before the process of role generation to generate the roles such also as auth_perms(r)={p_1,p_2,p_3}.

Results:

Our algorithm is less time consuming and generates less roles than traditional algorithm. Furthermore, the roles generated by the algorithm can better describe the real needs of the system and have better interpretability.

Conclusion:

The results show that the algorithm has superior performance and useful role generation compared to traditional algorithm.