bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the diversity of Poaceae-infecting mastreviruses on Reunion Island using a viral metagenomics-based approach
Authors: Claverie Sohini , Ouattara Alassane , Hoareau Murielle , Filloux Denis , Varsani Arvind , Roumagnac Philippe , Martin Darren P. , Lett Jean-Michel , Lefeuvre Pierre
Published: September 2019

Mostly found in Africa and its surrounding islands, African streak viruses (AfSV) represent the largest group of known mastreviruses. Of the thirteen AfSV species that are known to infect either cultivated or wild Poaceae plant species, six have been identified on Reunion Island. To better characterize AfSV diversity on this island, we undertook a survey of a small agroecosystem using a new metagenomics-based approach involving rolling circle amplification with random PCR amplification tagging (RCA-RA-PCR), high-throughput sequencing (Illumina HiSeq) and the mastrevirus reads classification using phylogenetic placement. Mastreviruses that likely belong to three new species were discovered and full genome sequences of these were determined by Sanger sequencing. The geminivirus-focused metagenomics approach we applied in this study was useful in both the detection of known and novel mastreviruses. The results confirm that Reunion Island is indeed a hotspot of AfSV diversity and that many of the mastrevirus species have likely been introduced multiple times. Applying a similar approach in other natural and agricultural environments should yield sufficient detail on the composition and diversity of geminivirus communities to precipitate major advances in our understanding of the ecology and the evolutionary history of this important group of viruses.
Isotopic variations of copper at the protein fraction level in neuronal human cells exposed in vitro to uranium
Authors: Paredes Eduardo , Malard Véronique , Vidaud Claude , Avazeri Emilie , Ortega Richard , Nonell Anthony , Isnard Hélène , Chartier Frédéric , Bresson Carole
Published: August 2019

Accurate isotope ratio determination was downscaled to the level of metal-containing protein fractions obtained from cell line lysates.
Anticancer organorhodium and -iridium complexes with low toxicity in vivo but high potency in vitro: DNA damage, reactive oxygen species formation, and haemolytic activity
Authors: Parveen Shahida , Hanif Muhammad , Leung Euphemia , Tong Kelvin K. H. , Yang Annie , Astin Jonathan , De Zoysa Gayan H. , Steel Tasha R. , Goodman David , Movassaghi Sanam , Söhnel Tilo , Sarojini Vijayalekshmi , Jamieson Stephen M. F. , Hartinger Christian G.
Published: August 2019

Dinuclear RhIII(Cp*) and IrIII(Cp*) complexes demonstrated potent in vitro anticancer activity while exhibiting low toxicity in haemolysis studies and in vivo zebrafish models.
Growth of W18O49/WOx/W dendritic nanostructures by one-step thermal evaporation and their high-performance photocatalytic activities in methyl orange degradation
Authors: Tang Xiufeng , Huang Jingcheng , Liao Huizhen , Chen Guoxin , Mo Zhaopeng , Ma Dingbang , Zhan Runze , Li Yudong , Luo Jianyi
Published: August 2019

A W18O49/WOx/W dendritic nanostructure was fabricated via self-assembly and acted as an integrated system in the photocatalytic process of MO degradation.
Retraction: Insight into the reversible structural crystalline-state transformation from MIL-53(Al) to MIL-68(Al)
Authors: Perea-Cachero Adelaida , Romero Enrique , Téllez Carlos , Coronas Joaquín
Published: September 2019

Retraction of ‘Insight into the reversible structural crystalline-state transformation from MIL-53(Al) to MIL-68(Al)’ by Adelaida Perea-Cachero et al., CrystEngComm, 2018, 20, 402–406.
Modeling solubility of CO2 gas in room temperature ionic liquids using the COSMOSAC-LANL model: a first principles study
Authors: Karmakar Anwesa , Mukundan Rangachary
Published: August 2019

We present a thermodynamic model for asymmetric solutions emphasising solute–solvent interactions. Solubility and selectivity prediction of CO2 and CH4 in ionic liquids is improved using ADF-COSMOSAC-2013 and the new LANL activity coefficient model.
Zn-Doped Cu(100) facet with efficient catalytic ability for the CO2 electroreduction to ethylene
Authors: Zhang Yuefeng , Zhao Yong , Wang Caiyun , Wei Zengxi , Yang Junliang , Ma Jianmin
Published: August 2019

Theoretical calculations demonstrate that Zn-doped Cu(100) facet possesses efficient catalytic ability for the CO2-to-C2H4 conversion. This work provides deep insights into the formation mechanism of C2H4 on transition metal doped Cu surface.
An MOF-derived copper@nitrogen-doped carbon composite: the synergistic effects of N-types and copper on selective CO2 electroreduction
Authors: Cheng Yuan-Sheng , Chu Xin-Ping , Ling Min , Li Na , Wu Kong-Lin , Wu Fang-Hui , Li Hong , Yuan Guozan , Wei Xian-Wen
Published: September 2019

N-doping carbon and copper derived from benzimidazole-modified Cu-BTC MOFs have synergistic effects on selective CO2 electroreduction.
Can mineral growth by oriented attachment lead to incorporation of uranium(vi) into the structure of goethite?
Authors: Soltis Jennifer A. , McBriarty Martin E. , Qafoku Odeta , Kerisit Sebastien N. , Nakouzi Elias , De Yoreo James J. , Ilton Eugene S.
Published: August 2019

Atomic and bulk scale measurements demonstrate that goethite grown by oriented aggregation does not readily incorporate U(vi) into structural sites.
Insights into the facet-dependent adsorption of phenylarsonic acid on hematite nanocrystals
Authors: Cao Shiyu , Zhang Xin , Huang Xiaopeng , Wan Shuhao , An Xuezheng , Jia Falong , Zhang Lizhi
Published: September 2019

Various methods were used to study the facet-dependent adsorption of PhAs on two model hematite samples: nanocubes with {012} facet and nanoplates with {001} facet.
Glycation affects differently the main soybean Bowman–Birk isoinhibitors, IBB1 and IBBD2, altering their antiproliferative properties against HT29 colon cancer cells
Authors: Olías Raquel , Becerra-Rodríguez Carmen , Soliz-Rueda Jorge R. , Moreno F. Javier , Delgado-Andrade Cristina , Clemente Alfonso
Published: September 2019

Glycation pattern of Bowman–Birk inhibitors from soybean affects their functional properties.
Rhodium(iii)-catalysed cascade [3 + 2] annulation ofN-aryloxyacetamides with 3-(hetero)arylpropiolic acids: synthesis of benzofuran-2(3H)-ones
Authors: Pan Jin-Long , Liu Tuan-Qing , Chen Chao , Li Quan-Zhe , Jiang Wei , Ding Tong-Mei , Yan Zhi-Qiang , Zhu Guo-Dong
Published: August 2019

We first reported the rhodium(iii)-catalyzed cascade [3 + 2] annulation ofN-aryloxyacetamides with propiolic acids affording benzofuran-2(3H)-ones.
Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward isochromeno[3,4-c]isoquinolines
Authors: Xu Shengbo , Qiao Shanshan , Sun Song , Yu Jin-Tao , Cheng Jiang
Published: August 2019

Rhodium-catalyzed C–H activation/annulation of amidines with 4-diazoisochroman-3-imines toward 8-amino-5H-isochromeno[3,4-c]isoquinolines with good functional group tolerance.
Synthesis and environment-dependent fluorescence behavior of a biaryl-conjugated (diphenylmethylene)imidazolinone
Authors: Ikejiri Masahiro , Nishiguchi Ryouta , Kubota Chikoto , Fujisaka Aki , Miyashita Kazuyuki
Published: August 2019

A GFP chromophore analog, bar-DAIN, which equips 2-biaryl and 5-diphenylmethylene moieties, shows environment-dependent fluorescence behavior for viscous and aggregative conditions.
Advanced electrospun nanomaterials for highly efficient electrocatalysis
Authors: Lu Xiaofeng , Li Meixuan , Wang Huiyuan , Wang Ce
Published: August 2019

We highlight the recent developments of electrospun nanomaterials with controlled morphology, composition and architecture for highly efficient electrocatalysis.
A rough endoplasmic reticulum-like VSe2/rGO anode for superior sodium-ion capacitors
Authors: Wu Yuanke , Chen Hao , Zhang Longcheng , Li Qiulin , Xu Maowen , Bao Shu-juan
Published: August 2019

A rough endoplasmic reticulum-like VSe2/rGO were designed to tackle the sluggish sodium ion storage and severe volume expansion in a sodium ion capacitor.
Synthesis and application of Bi2WO6for the photocatalytic degradation of two typical fluoroquinolones under visible light irradiation
Authors: Huang Cong , Chen Leilei , Li Haipu , Mu Yanguang , Yang Zhaoguang
Published: September 2019

Bismuth tungstate was successfully synthesized in a shorter duration by a method combining ultrasonic solvothermal treatment and high-temperature calcination.
Structural complexities and sodium-ion diffusion in the intercalates NaxTiS2: move it, change it, re-diffract it
Authors: Wiedemann Dennis , Suard Emmanuelle , Lerch Martin
Published: September 2019

The structure of NaxTiS2-3R1was revised and honeycomb-like pathways with their barriers of sodium-ion migration were found based on high-temperature neutron diffraction.
Low-temperature selective catalytic dehydrogenation of methylcyclohexane by surface protonics
Authors: Takise Kent , Sato Ayaka , Ogo Shuhei , Seo Jeong Gil , Imagawa Ken-ichi , Kado Shigeru , Sekine Yasushi
Published: September 2019

Electric field facilitated MCH dehydrogenation at 423 K without methane and coke by-production over Pt/TiO2 catalyst by surface protonics.
Selective synthesis of formamides, 1,2-bis(N-heterocyclic)ethanes and methylamines from cyclic amines and CO2/H2 catalyzed by an ionic liquid–Pd/C system
Authors: Li Ruipeng , Zhao Yanfei , Wang Huan , Xiang Junfeng , Wu Yunyan , Yu Bo , Han Buxing , Liu Zhimin
Published: September 2019

The reduction of CO2 with amines and H2 generally produces N-formylated or N-methylated compounds over different catalysts.
Exploration of iron borides as electrochemical catalysts for the nitrogen reduction reaction
Authors: Li Qinye , Liu Chuangwei , Qiu Siyao , Zhou Fengling , He Lizhong , Zhang Xiwang , Sun Chenghua
Published: August 2019

Iron hypercoordinated with boron is a promising catalyst for the nitrogen reduction reaction.
A Co–Mo2N composite on a nitrogen-doped carbon matrix with hydrogen evolution activity comparable to that of Pt/C in alkaline media
Authors: Lang Xuewei , Qadeer Muhammad Abdul , Shen Guoqiang , Zhang Rongrong , Yang Sichao , An Jiayi , Pan Lun , Zou Ji-Jun
Published: August 2019

Co–Mo2N@NC exhibits comparable hydrogen evolution reaction activity with that of Pt/C because of the improvement of intrinsic activity and electrical conductivity.
Mesoporous amorphous Al2O3/crystalline WO3 heterophase hybrids for electrocatalysis and gas sensing applications
Authors: Zou Yidong , Xi Shibo , Bo Tao , Zhou Xinran , Ma Junhao , Yang Xuanyu , Diao Caozheng , Deng Yonghui
Published: September 2019

Unprecedented mesoporous amorphous–crystalline Al2O3/WO3 exhibit superior HER activity with addition of Al2O3 (>2%) while lower contents (<2%) show excellent sensing performance owing to hetero-interface and lattice distortion of the octahedron crystal.
Correction: Interplay between H2O and CO2 coadsorption and space-charge on Y-doped BaZrO3 surfaces
Authors: Polfus Jonathan M. , Yang Jing , Yildiz Bilge
Published: August 2019

Correction for ‘Interplay between H2O and CO2 coadsorption and space-charge on Y-doped BaZrO3 surfaces’ by Jonathan M. Polfus et al., J. Mater. Chem. A, 2018, 6, 24823–24830.
In situ-forming, mechanically resilient hydrogels for cell delivery
Authors: Young Stuart A. , Riahinezhad Hossein , Amsden Brian G.
Published: September 2019

Injectable, in situ-forming hydrogels can improve cell delivery in tissue engineering applications by facilitating minimally invasive delivery to irregular defect sites and improving cell retention and survival.
Three dimensional graphene-supported nitrogen-doped carbon nanotube architectures for attenuation of electromagnetic energy
Authors: Zhang Xiao , Zhang Xinci , Wang Deting , Yuan Haoran , Zhang Shen , Zhu Chunling , Zhang Xitian , Chen Yujin
Published: September 2019

Three dimensional graphene-supported nitrogen-doped carbon nanotube architectures with high electrical conductivities, abundant defects, multiple interfaces and nitrogen dopants exhibited excellent attenuation properties of electromagnetic energy.
Analysis of Amount and Style of Oral Interaction Related to Language Outcomes in Children With Hearing Loss: A Systematic Review (2006–2016)
Authors: Sultana Nuzhat , Wong Lena L. N. , Purdy Suzanne C.
Published: September 2019

Purpose

This systematic review summarizes the evidence for differences in the amount of language input between children with and without hearing loss (HL). Of interest to this review is evaluating the associations between language input and language outcomes (receptive and expressive) in children with HL in order to enhance insight regarding what oral language input is associated with good communication outcomes.

Method

A systematic review was conducted using keywords in 3 electronic databases: Scopus, PubMed, and Google Scholar. Keywords were related to language input, language outcomes, and HL. Titles and abstracts were screened independently, and full-text manuscripts meeting inclusion criteria were extracted. An appraisal checklist was used to evaluate the methodological quality of studies as poor, good, or excellent.

Results

After removing duplicates, 1,545 study results were extracted, with 27 eligible for full-text review. After the appraisal, 8 studies were included in this systematic review. Differences in the amount of language input between children with and without HL were noted. Conversational exchanges, open-ended questions, expansions, recast, and parallel talk were positively associated with stronger receptive and expressive language scores. The quality of evidence was not assessed as excellent for any of the included studies.

Conclusions

This systematic review reveals low-level evidence from 8 studies that specific language inputs (amount and style) are optimal for oral language outcomes in children with HL. Limitations were identified as sample selection bias, lack of information on control of confounders and assessment protocols, and limited duration of observation/recordings. Future research should address these limitations.
Energy storage solution for wireless sensor network used in bridge surface corrosion monitoring
Authors: Fujimoto T. , Uto S. , Ishizuka Y. , Fujishima T. , Guan C.‐E. , Okumatsu T. , Sugimoto S. , Iwasaki S.
Published: August 2019

This Letter presents a radio‐frequency energy storage solution for monitoring corrosion on bridge in wireless sensor network system. In this monitoring system, wireless terminals and sensors are installed on the bridges to monitor surface corrosion remotely. The proposed energy storage module to supply power to the sensors consists of a rectifier, a supercapacitor, and a DC–DC boost converter. The rectifier circuit is designed to convert 920 MHz RF energy to DC source. Experimental results demonstrate that the harvested energy can power up the sensor nodes for several times in a week, at input power density of 0.81 μW/cm2.
Demonstration of modulating retro‐reflection free‐space optical transmission using 80 Gb/s Pol‐MUX QPSK signal in simulated atmosphere environment
Authors: Feng Xianglian , Jiang Hexin , Wu Zhihang , Wang Tianshu , Jiang Huilin , Gao Shiming
Published: August 2019

The authors experimentally demonstrate a modulating retro‐reflector based on electro‐optical in‐phase quadrature modulator and test it in an atmospheric cell simulated atmosphere environment by using 80 Gb/s polarisation‐multiplexing quadrature phase‐shift keying (Pol‐MUX QPSK) signals. At the BER of 1 × 10−3, the power penalties of the x‐ and y‐polarisation signals are both <1.1 dB when the temperature difference in the atmospheric cell is <250°C.
Improved sufficient condition of ℓ1–2‐minimisation for robust signal recovery
Authors: Wang Wendong , Wang Jianjun
Published: August 2019

By means of the restricted isometry property of order k and the restricted orthogonality property of order (k,k), this Letter mainly establishes an improved sufficient condition for a recently emerged ‐minimisation to guarantee the robust signal recovery. The obtained condition is proved to be much better than the state‐of‐the‐art ones for almost all parameters k.
High‐selective triple‐mode bandpass filter using a new capacitive‐loaded patch resonator
Authors: Liu Qing , Zhou Dongfang , Zhang Dewei , Wang Xian
Published: August 2019

This Letter proposes a novel high‐selective triple‐mode bandpass filter based on a patch resonator. The new triple‐mode patch resonator is realised by the traditional dual‐mode square patch with a floating capacitive‐loaded metal patch. The resonance of one higher‐order mode can be independently shifted to that of two fundamental modes to form a passband. Based on the proposed filter, three finite‐transmission zeros can be produced, and two of them can be controlled well. For the demonstration, a triple‐mode patch filter with the centre frequency of 3.5 GHz was designed, fabricated and measured.
Directional mobile charging method for mine Internet of things
Authors: Hu Qingsong , Cheng Yong , Li Binghao , Wang Yajun , Li Shiyin
Published: August 2019

The nodes of the mine Internet of things (MIoT) are powered by batteries, for which the wireless charging is essential for their continuous and stable operation. This study proposed a method of directional mobile charging for the MIoT based on smart antenna, in which the mobile chargers charge the nodes need power not only when stationary, but also when moving. The theoretical calculation method of the charged energy is studied and established its approximate calculation algorithm, which can greatly reduce the computational complexity, based on the discretised model of effective charging distance of smart antenna. Then, the method for estimating the residual energy of the nodes was designed, and the upper bound of the transmitting power of the mobile charger was determined. The results of the simulation experiments indicated that this method has high charging efficiency and can meet the power demand of MIoT nodes.
ZF detectors for uplink distributed massive MIMO systems over Rayleigh‐inverse Gaussian composite fading channels
Authors: Pradhan Bibhuti Bhusan , Roy Lakshi Prosad
Published: August 2019

Massive multiple‐input multiple‐output (MIMO), together with distributed antenna systems has emerged as a promising technology in modern wireless networks because of their remarkable capacity potential and link reliability. The combined architecture, that is distributed massive MIMO (DM‐MIMO) comprises of arbitrarily located multiple radio ports (RPs) each having more than one antennas and a base station containing asymptotically large number of antennas. At the outset, the instantaneous output signal to noise ratio (SNR) corresponding to individual subchannel is obtained for ZF detector. Subsequently, closed form expression of exact and high SNR approximated ergodic capacity are obtained in the context of DM‐MIMO. The lower bound of ergodic capacity are then derived using a generalized approach, which may be applicable to all composite fading channels. Moreover, lower bound over all users are formulated in closed form considering large number of RPs located in a circular topology. In subsequent analysis, SER and OP characterization of the ZF detector over DM‐MIMO channel is presented with tractable mathematical expressions. In addition to the per subchannel based SER, the global average SER is also evaluated for the considered configurations. Finally, the implications of model parameters on ZF detectors are analysed through a set of Monte‐Carlo simulations.
Adaptive back‐stepping cancer control using Legendre polynomials
Authors: Khorashadizadeh Saeed , Akbarzadeh Kalat Ali
Published: August 2019

Here, a model‐free controller for cancer treatment is presented. The treatment objective is to find a proper drug dosage that can reduce the population of tumour cells. Recently, some solutions have been proposed according to the control theory. In these approaches, based on the mathematical description of the number of effector cells, tumour cells, and concentration of the interleukin‐2 (IL‐2), a non‐linear controller is designed. Here, based on the back‐stepping design procedure and function approximation property of Legendre polynomials, a novel controller for MIMO cancer immunotherapy is presented. In fact, Legendre polynomials play the role of uncertainty estimation and compensation. In comparison with other uncertainty estimators such as neural networks, Legendre polynomials have simpler structure. Thus, the contribution of this study is simplifying the design procedure and reducing the controller computational load in comparison with Neuro‐Fuzzy controllers. The resulting closed‐loop system is capable of overcoming various uncertainties. Simulation results verify the efficiency of the proposed method in the fast reduction of tumour cells. Moreover, a comparison between the performance of Legendre polynomials and a radial basis functions neural network (RBFN) is presented.
Indoor non‐rhythmic human motion classification using a frequency‐modulated continuous‐wave radar
Authors: Zou Yu , Ding Chuanwei , Hong Hong , Li Changzhi , Zhu Xiaohua
Published: September 2019

Human motion classification is widely used in intelligent house, surveillance, search and rescue operation, intelligent house, and elder monitoring. In this study, a frequency‐modulated continuous‐wave radar is utilised to classify non‐rhythmic human motion in an indoor scenario. Both the range and Doppler features are extracted from echo signals for a machine learning classifier subspace K ‐nearest neighbour. Extensive experiments demonstrate its feasibility, and an accuracy rate of 94.2% was achieved in recognition of eight typical non‐rhythmic motions.
Systematic search for stellar pulsators in the eclipsing binaries observed byKepler
Authors: Gaulme Patrick , Guzik Joyce A.
Published: August 2019

Eclipsing binaries (EBs) are unique targets for measuring precise stellar properties and can be used to constrain stellar evolution models. In particular, it is possible to measure masses and radii of both components of a double-lined spectroscopic EB at the percent level. Since the advent of high-precision photometric space missions (MOST, CoRoT,Kepler, BRITE, TESS), the use of stellar pulsation properties to infer stellar interiors and dynamics constitutes a revolution for studies of low-mass stars. TheKeplermission has led to the discovery of thousands of classical pulsators such asδScuti and solar-like oscillators (main sequence and evolved), but also almost 3000 EBs with orbital periods shorter than 1100 days. We report the first systematic search for stellar pulsators in the entireKeplerEB catalog. The focus is mainly aimed at discoveringδScuti,γDoradus, red giant, and tidally excited pulsators. We developed a data inspection tool (DIT) that automatically produces a series of plots from theKeplerlight curves that allows us to visually identify whether stellar oscillations are present in a given time series. We applied the DIT to the wholeKeplerEB database and identified 303 systems whose light curves display oscillations, including 163 new discoveries. A total of 149 stars are flagged asδScuti (100 from this paper), 115 asγDoradus (69 new), 85 as red giants (27 new), and 59 as tidally excited oscillators (29 new). There is some overlap among these groups, as some display several types of oscillations. Despite the likelihood that many of these systems are false positives, for example, when an EB light curve is blended with a pulsator, this catalog gathers a vast sample of systems that are valuable for a better understanding of stellar evolution.
Narzissmus und Macht in Politik und Gesellschaft
Authors: Wirth Hans-Jürgen
Published: September 2019

Einerseits streben narzisstische Persönlichkeiten häufig nach Macht, andererseits fördert Macht die Entwicklung narzisstischer Persönlichkeitseigenschaften.
Beides begünstigt den Missbrauch von Macht. Macht hat aber auch eine Struktur schaffende und damit elementare gesellschaftliche Funktion. Rationale und
sachbezogene Machtausübung ist auf der psychologischen Ebene der Persönlichkeitsentwicklung häufig mit konstruktiven Eigenschaften wie Selbstwirksamkeit,
Selbstbewusstsein, gesundem Narzissmus und Führungsqualitäten verbunden.
Diagnostische Verfahren zur Messung des Narzissmus
Authors: Bierhoff Hans-Werner , Brailovskaia Julia , Rohmann Elke
Published: September 2019

Die Bedeutung des Persönlichkeitsmerkmals Narzissmus in der modernen Gesellschaft nimmt zu. Dabei spielt die Einbeziehung narzisstischer Inhalte in den Medien
eine wesentliche Rolle. Die Erfassung des Narzissmus ist mit verschiedenen Methoden möglich: So wurde beispielsweise festgestellt, dass Aktivitäten auf
Facebook Rückschlüsse auf den Narzissmus der Nutzer ermöglichen 1. Wir stellen hier die Fragebogenmethode in den
Mittelpunkt, die es ermöglicht, 2 Subtypen des Narzissmus – Grandiosität und Vulnerabilität – zu messen.
Update Mammakarzinom 2019 Teil 1 – Implementierung der Ergebnisse neuer Studienkonzepte beim frühen Mammakarzinom in die klinische Praxis
Authors: Hartkopf Andreas D. , Müller Volkmar , Wöckel Achim , Lux Michael P. , Janni Wolfgang , Nabieva Naiba , Taran Florin-Andrei , Ettl Johannes , Lüftner Diana , Belleville Erik , Schütz Florian , Fasching Peter A. , Fehm Tanja N. , Kolberg Hans-Christian , Overkamp Friedrich , Schneeweiss Andreas , Tesch Hans
Published: August 2019

In der Prävention und Behandlung des frühen Mammakarzinoms sind über die Jahre immer wieder kleine, aber bedeutsame Fortschritte gemacht worden. In der Prävention gewinnen die sogenannten Panel-Gen-Analysen immer mehr an Bedeutung, da das durch die getesteten Gene bedingte Risiko immer besser verstanden wird und somit Konzepte für die Integration in die Krankenversorgung erarbeitet werden können. In der adjuvanten Situation konnte die erste Studie in der sogenannten post-neoadjuvanten Situation bei fehlender pathologischer Komplettremission nach Trastuzumab oder Pertuzumab + Trastuzumab eine deutliche Verbesserung der Prognose zeigen. Weitere Studien mit diesem post-neoadjuvanten Therapiekonzept werden zurzeit noch durchgeführt. Die CDK4/6-Inhibitoren, die in der metastasierten Situation eine deutliche Verbesserung des progressionsfreien Überlebens gezeigt hatten, werden zurzeit in der adjuvanten Situation in großen Therapiestudien getestet. Diese und weitere neue Daten zur Behandlung oder Prävention des primären Mammakarzinoms werden in dieser Übersichtsarbeit vor dem Hintergrund aktueller Studien vorgestellt.
Update Mammakarzinom 2019 Teil 2 – Implementierung neuer Diagnostika und Therapien bei Patientinnen mit fortgeschrittenem Brustkrebs in der klinischen Praxis
Authors: Janni Wolfgang , Schneeweiss Andreas , Müller Volkmar , Wöckel Achim , Lux Michael P. , Hartkopf Andreas D. , Nabieva Naiba , Taran Florin-Andrei , Tesch Hans , Overkamp Friedrich , Lüftner Diana , Belleville Erik , Schütz Florian , Fasching Peter A. , Fehm Tanja N. , Kolberg Hans-Christian , Ettl Johannes
Published: August 2019

Die Behandlung von Patientinnen mit fortgeschrittenem Mammakarzinom hat sich in den letzten Jahren weiterentwickelt. Zusätzlich zum Therapiefortschritt in den etablierten Subgruppen (Hormonrezeptor- und HER2-Status) gibt es nun Therapien, die sich an einzelnen molekularen Charakteristika orientieren, wie zum Beispiel die PARP-Inhibitor-Therapie bei BRCA-mutierten Patientinnen. Zusätzlich dazu sind Tests in der Entwicklung, die innerhalb von Subgruppen weitere Marker etablieren sollen, um die Wirksamkeit einer Therapie vorherzusagen. Die PI3K-Mutationstestung bei HER2-negativen, hormonrezeptorpositiven Tumoren und die PD‑L1-Testung von Immunzellen bei triple-negativen Tumoren werden voraussichtlich in der klinischen Praxis etabliert, um Patientinnen für die jeweiligen Therapien auszuwählen. Mit neuen Therapieansätzen treten auch neue Nebenwirkungen auf. Das Management dieser Nebenwirkungen ebenso wie die der klassischen Therapien (supportive Therapie) ist mit der Einführung neuer Behandlungen essenziell, um die Lebensqualität der Patientinnen zu erhalten. Das Wissen über Maßnahmen zur Erhaltung und Verbesserung der Lebensqualität hat in den letzten Jahren deutlich zugenommen. Lifestyle-Faktoren sollten dabei ebenso Berücksichtigung finden wie moderne Therapieverfahren. Diese Übersichtsarbeit fasst die neuesten Studien und Veröffentlichungen zusammen und bewertet sie in Bezug auf die Relevanz für die klinische Praxis.
Evolution of Blepharoplasty
Authors: Hicks Katherine , Sclafani Anthony P. , Thomas James Regan
Published: August 2019

The eyes and periorbital region are central components of facial beauty and harmony, but the periorbital region is also one of the earliest to show signs of aging. Over the past few decades, significant progress has been made in our understanding of the anatomy in this area, as well as the deleterious effects of aging in this region. In turn, surgical philosophy and techniques have evolved to better combat changes in this area to achieve a more youthful, natural appearance.
Once Upon a Rhinoplasty: The History of the “Queen” of Facial Plastic Surgery
Authors: Adamson Peter A. , Gantous Andres
Published: August 2019

The history of rhinoplasty is absolutely fascinating. It is replete with mysterious practices, intrigue, and imaginative thoughts. If necessity is the mother of invention, then sex, crimes, and punishment lay a legitimate claim to being the mother of rhinoplasty. The history of rhinoplasty is a global saga spanning the millennia. Practitioners of the art and science have included those demonstrating the most admirable traits espoused in the Hippocratic Oath, as well as those to whom the word “charlatan” might more aptly be applied. The truth of a story is illustrated in its telling, and we have attempted to be true historians. We recognize that observers and narrators, now well past (sic), have determined many of today's truths, and therefore their stories become our truths whether they were so or not. We have attempted to reference many who have contributed to the advance of this amazing surgical procedure, recognizing that we may have included some who have demonstrated marginal merit to be so. Assuredly, we have also unintentionally omitted some whom we should have included. From them we ask forbearance. Let the story begin, “Once upon a time…”
Return to Play after Anterior Cruciate Ligament Reconstruction among Amateur Soccer Players
Authors: Alonso Julián , Malig Samuel , Fontboté Cristián , Azar Camilo , Vergara Francisco , Yáñez Roberto
Published: September 2019

Objective The aim of the present study is to assess the return to play among amateur soccer league players after anterior cruciate ligament (ACL) reconstruction.

Materials and Method The surgical protocols of ACL reconstruction surgeries performed in a sports medicine clinic from July 1st, 2013, to June 30th, 2014, were included in the study. Only the charts of amateur soccer league players who played once or twice a week were selected. The follow-up time was calculated as the number of months between surgery and the telephone survey. At the follow-up, the current status of the soccer playing was recorded. Those patients who were no longer playing in a team were asked what kind of sport they were currently practicing, as well as the main reason for not returning to team playing.

Results A total of 61 (25.6%) patients met the inclusion criteria. The mean follow-up time was of 22.4 ± 3.4 months. At the follow-up, 30 (49.1%) patients were playing in amateur soccer teams. Among the patients who were no longer playing in a team, 19 (61.2%) were playing soccer occasionally, 11 (35.4%) were practicing other sports, and 1 developed a sedentary life style. The reasons for not returning to team playing were: fear of reinjury in 26%; knee symptoms in 26%; lack of confidence in the knee in 23%, family or job commitments in 23%; and not being eligible to participate in competitive sports in 2%.

Conclusion After an average of two years of ACL reconstruction, only half of the amateur soccer league players return to play.
Patellar Impingement on Tibial Polyethylene after Primary Total Knee Arthroplasty without Patellar Resurfacing
Authors: Hwang Bo-Hyun , Jung Kwang-Am , Ong Alvin , Ahn Hye-Sun , Moon Seong-Hwan , Lee Su-Chan
Published: August 2019

Patellar impingement on tibial polyethylene (PIP) is one potential complication of total knee arthroplasty (TKA). When PIP occurs, it is often related to inaccurate restoration of the joint line or due to soft-tissue contracture. We investigated the prevalence and etiology of PIP in Asian patients with deeply flexed knees following posterior stabilized (PS)-TKA. We retrospectively reviewed 54 patients (65 knees) with PIP after primary PS-TKAs without patellar resurfacing performed between 2008 and 2011. These patients were compared with a group of 124 patients (130 knees) without PIP matched for age, sex, and body mass index (BMI). The minimum follow-up was 5 years (range, 5–8.1 years). Patients were evaluated by blinded, independent observers using the Oxford knee score, the Waters score, and radiographic parameters. Impingement between the patella and the tibial polyethylene had a mean onset of 13.5 months after PS-TKA. The development of PIP was significantly associated with change in patellar tendon length (odds ratio [OR] = 11.4, 95% confidence interval [CI]: 11.2–11.6%), shorter postoperative patellar tendon length (OR = 2.1, 95% CI: 1.8–2.5%), change in the Insall–Salvati ratio (OR = 0.9, 95% CI: 0.8–1.0%), and joint line elevation (OR = 5.3, 95% CI: 4.8–5.8%) on multiple logistic regression analysis. Our findings reinforce the importance of accurate joint line restoration and the avoidance of iatrogenic injury to the patellar tendon, which can lead to shortening of the patellar tendon. This is a retrospective comparative study and its level of evidence is III.
Prone versus Supine Position for Lung Ultrasound in Neonates with Respiratory Distress
Authors: Louis Deepak , Belen Karen , Farooqui Mansoor , Idiong Nnanake , Amer Reem , Hussain Abrar , ElSayed Yasser
Published: September 2019

Objective To study the feasibility of lung ultrasound (LUS) in prone position and to compare it with supine position in neonates with respiratory distress.

Study Design Neonates ≥ 29 weeks of gestational age with respiratory distress requiring respiratory support within first 12 hours of life were enrolled prospectively. First LUS (fLUS) was done in the position infant was nursed (supine or prone), infant’s position changed, a second LUS (sLUS) was performed immediately and a third LUS (tLUS) was done 1 to 2 hours later. Primary outcome was the comparison of LUS scores (LUSsc) between fLUS and sLUS.

Results Sixty-four neonates were enrolled. Common respiratory diagnoses were transient tachypnea of newborn (TTN; 53%) and respiratory distress syndrome (RDS; 41%). LUSsc was different between fLUS and sLUS (fLUSsc 6 [interquatile range: 4, 7] vs. sLUSsc 7 [4, 10], p < 0.001), while there was no difference between the fLUS and tLUS (fLUSsc 6 [4, 7] vs. tLUSsc 5 [3, 7], p = 0.43). Subgroup analysis confirmed similar findings in neonates with TTN, while in babies with RDS, all the three LUSsc were similar.

Conclusion LUS is feasible in prone position in neonates. LUS scores were higher immediately after a change in position but were similar to baseline 1 hour after the change in position.
Vibration-modified torsional potentials and vibration-torsion (“vibtor”) levels in the m-fluorotoluene cation
Authors: Kemp David J. , Fryer Elizabeth F. , Davies Alexander R. , Wright Timothy G.
Published: August 2019

Zero-kinetic-energy (ZEKE) spectra are presented for m-fluorotoluene, employing different low-lying (<350 cm−1) intermediate torsional and vibration-torsional (“vibtor”) levels of the S1 state. The adiabatic ionization energy (AIE) is found to be 71 997 ± 5 cm−1 (8.9265 ± 0.0006 eV). It is found that the activity in the ZEKE spectra varies greatly for different levels and is consistent with the assignments of the S1 levels deduced in the recent fluorescence study of Stewart et al. [J. Chem. Phys. 150, 174303 (2019)]. For cation torsional levels, the most intense band corresponds to changes in the torsional quantum number, in line with the known change in the phase of the torsional potential upon ionization. This leads to the observation of an unprecedented number of torsions and vibtor levels, with the pronounced vibtor activity involving out-of-plane vibrations. Interactions between levels involving torsions are discussed, with evidence presented, for the first time it is believed, for modification of a torsional potential induced by a vibration. Also, we discuss the possibility of distortion of the methyl group leading to a change from G6 molecular symmetry to Cs point group symmetry.
Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments
Authors: Shen Yaoqing , Grisdale Cameron J. , Islam Sumaiya A. , Bose Pinaki , Lever Jake , Zhao Eric Y. , Grinshtein Natalie , Ma Yussanne , Mungall Andrew J. , Moore Richard A. , Lun Xueqing , Senger Donna L. , Robbins Stephen M. , Wang Alice Yijun , MacIsaac Julia L. , Kobor Michael S. , Luchman H. Artee , Weiss Samuel , Chan Jennifer A. , Blough Michael D. , Kaplan David R. , Cairncross J. Gregory , Marra Marco A. , Jones Steven J. M.
Published: August 2019

Glioblastoma multiforme (GBM) is the most deadly brain tumor, and currently lacks effective treatment options. Brain tumor-initiating cells (BTICs) and orthotopic xenografts are widely used in investigating GBM biology and new therapies for this aggressive disease. However, the genomic characteristics and molecular resemblance of these models to GBM tumors remain undetermined. We used massively parallel sequencing technology to decode the genomes and transcriptomes of BTICs and xenografts and their matched tumors in order to delineate the potential impacts of the distinct growth environments. Using data generated from whole-genome sequencing of 201 samples and RNA sequencing of 118 samples, we show that BTICs and xenografts resemble their parental tumor at the genomic level but differ at the mRNA expression and epigenomic levels, likely due to the different growth environment for each sample type. These findings suggest that a comprehensive genomic understanding of in vitro and in vivo GBM model systems is crucial for interpreting data from drug screens, and can help control for biases introduced by cell-culture conditions and the microenvironment in mouse models. We also found that lack of
MGMT
expression in pretreated GBM is linked to hypermutation, which in turn contributes to increased genomic heterogeneity and requires new strategies for GBM treatment.
Historical records reveal the distinctive associations of human disturbance and extreme climate change with local extinction of mammals
Authors: Wan Xinru , Jiang Guangshun , Yan Chuan , He Fangliang , Wen Rongsheng , Gu Jiayin , Li Xinhai , Ma Jianzhang , Stenseth Nils Chr. , Zhang Zhibin
Published: September 2019

Significance

Human impacts and climatic changes are widely considered to be responsible for rapid species extinction. However, determining their effects is challenging owing to the lack of long-term spatial–temporal data. In this study, we quantified the distinctive associations of anthropogenic and climatic stressors with the local extinction of 11 medium- or large-sized mammals using historical records over the past 3 centuries. We found that the increased local extinction of mammals was associated with intensified human disturbance (particularly for large-sized mammals) and with extreme temperature change (both cooling and warming). Our results provide insight into biodiversity conservation during the Anthropocene.
Statistical inference of body representation in the macaque brain
Authors: Fang Wen , Li Junru , Qi Guangyao , Li Shenghao , Sigman Mariano , Wang Liping
Published: September 2019

Significance

How humans and potentially other animals construct the experience of ”being a self" remains one of the most intriguing questions in neuroscience. Over the past years, substantial advances have been made in understanding psychological mechanisms of bodily self through experimental manipulations in humans, such as rubber-hand illusion in which arbitrary objects may be ascribed with ownership and perceived as part of the self. The present study provides a demonstration in macaque monkeys and establishes objective and quantitative signatures of body representation at a single-trial level. Furthermore, we show that neural signals in macaque’s premotor cortex reflect the strength of illusion and the likelihood of misattributing the illusory arm to oneself, thus, revealing a cortical representation of bodily self-consciousness.
Widespread male sex bias in mammal fossil and museum collections
Authors: Gower Graham , Fenderson Lindsey E. , Salis Alexander T. , Helgen Kristofer M. , van Loenen Ayla L. , Heiniger Holly , Hofman-Kamińska Emilia , Kowalczyk Rafał , Mitchell Kieren J. , Llamas Bastien , Cooper Alan
Published: September 2019

Significance

The extent to which the fossil record provides an accurate picture of past life is an important issue that is often difficult to assess. We genetically sexed 277 mammalian subfossils using high-throughput sequencing of ancient DNA, and found a strong male bias (∼75%) in Pleistocene bison (
n
= 186) and brown bears (
n
= 91), matching signals previously reported for mammoth. Similarly, a male bias was also found in species of nearly all mammal orders in 4 large museum collections. For mammals, we suggest both male behavior and appearance can lead to increased chances of representation in fossil and museum collections, and this previously unrecognized sex bias could have substantial implications for views of past population and ecological processes.
Overproduction of H
2
S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome
Authors: Panagaki Theodora , Randi Elisa B. , Augsburger Fiona , Szabo Csaba
Published: September 2019

Down syndrome (DS) is associated with significant perturbances in mitochondrial function. Here we tested the hypothesis that the suppression of mitochondrial electron transport in DS cells is due to high expression of cystathionine-β-synthase (CBS) and subsequent overproduction of the gaseous transmitter hydrogen sulfide (H
2
S). Fibroblasts from DS individuals showed higher CBS expression than control cells; CBS localization was both cytosolic and mitochondrial. DS cells produced significantly more H
2
S and polysulfide and exhibited a profound suppression of mitochondrial electron transport, oxygen consumption, and ATP generation. DS cells also exhibited slower proliferation rates. In DS cells, pharmacological inhibition of CBS activity with aminooxyacetate or siRNA-mediated silencing of CBS normalized cellular H
2
S levels, restored Complex IV activity, improved mitochondrial electron transport and ATP synthesis, and restored cell proliferation. Thus, CBS-derived H
2
S is responsible for the suppression of mitochondrial function in DS cells. When H
2
S overproduction is corrected, the tonic suppression of Complex IV is lifted, and mitochondrial electron transport is restored. CBS inhibition offers a potential approach for the pharmacological correction of DS-associated mitochondrial dysfunction.
Textäquivalenz in der serbischen Übersetzung von Georg Trakls Spätlyrik
Authors: Zobenica Nikolina
Published: August 2019

According to functional theories, the translation process is a specific and receiver-dependent action, the Skopos
of which, however, does not always have to correspond to that of the source text. According to functionalism, the communicative
function of a text can be different in the target culture, and the translation should be adapted accordingly to the new Skopos. In
translating, the focus is no longer on equivalence but on the adequacy of the translation, although in the best case equivalence
or consistency of function should be sought. Since this is rarely entirely feasible, the translators themselves should decide in
the course of the translation process which text dimension they would give priority to: semantic (content), syntactic (form) or
pragmatic (meaning). A text grammatical and text semantic analysis of the coherence and isotope in the translation of Georg
Trakl’s poems into Serbian aims to determine which dimension the translator Branimir Živojinović preferred. The study has shown
that he almost completely achieves text equivalence, with few deviations in favour of form, which, however, do not disturb the
coherence of the selected corpus.
Islamic motivation for tourism and contradictions of the American tradition.
Authors: Korstanje M. E.
Published: August 2019

This chapter debates the nature of Islamic tourism and the limitations and contradictions of the American tradition, a new emerging academic school that dates back tourism as a direct result of the Industrial Revolution. The chapter puts the American tradition and its development of secularization versus religion under scrutiny.
Introduction.
Authors: Laksono N. D. , Setiawati U. , Nur F. , Rahmaningsih M. , Anwar Y. , Rusfiandi H. , Forster B. P. , Sembiring E. H. , Subbarao A. S. , Zahara H.
Published: August 2019

The performance of oil palm plantations is determined from an early stage by the quality of the planting materials. These are mainly seedlings, but ramets (usually produced from tissue culture cloning) are also used. Raising seedlings and ramets is performed in a nursery. The aim of oil palm plantations is to produce high yields, and a basic necessity is the provision of good quality planting materials. This in turn requires good nursery practices. Direct planting of oil palm seed is possible, but it cannot produce uniform materials. Nursery-grown seedlings or ramets provide healthy, strong and uniform planting materials at a suitable stage for field planting, which results in good seedling/ramet establishment and thus a high yield potential. Nursery practices are therefore a critical component of the oil palm plantation industry. In addition to commercial young plant production, seedlings and ramets are also needed for trialling (young plant screening and mature palm field performance testing) to assess progenies and breeding lines for selection and breeding and materials for pest and disease resistance or tolerance to abiotic stresses and responses to, and suitability for, changing agronomic practices and new planting materials.
Pre-nursery activities.
Authors: Laksono N. D. , Setiawati U. , Nur F. , Rahmaningsih M. , Anwar Y. , Rusfiandi H. , Forster B. P. , Sembiring E. H. , Subbarao A. S. , Zahara H.
Published: August 2019

The pre-nursery is a key part of the double-stage nursery and is the major difference between single- and double-stage nurseries. The activities involve the preparation of small planting bags, which are close-packed (no spacing). Thus, the area needed is minimal. Abnormal palms are easily observed and discarded, so only good quality palms are grown on. This chapter describes the bed preparation for small planting bags, the layout to assist watering and fertiliser treatments, how to avoid flooding, how to fill the planting bags with soil, pre-treatments of seeds and ramets, how to sow germinated seed and plant ramets, how to provide and construct shading and, once established, how to pot-on into large planting bags. The tools, equipment and materials needed are also listed.
Watering.
Authors: Laksono N. D. , Setiawati U. , Nur F. , Rahmaningsih M. , Anwar Y. , Rusfiandi H. , Forster B. P. , Sembiring E. H. , Subbarao A. S. , Zahara H.
Published: August 2019

Correct watering is essential for healthy plant production. Deficient or excessive water will result in poor plant growth. Watering should avoid plant disturbance as this can lead to plant stress. This chapter describes guidelines and methods in watering application.