bluuebunny/crossref_metadata_2025 huggingface dataset:
Le droit suisse des sociétés en 2022 : Modifications législatives et jurisprudence partiellement commentée
Authors: Canapa Damiano , Grisoni Arthur , Antonoff Marine , Gherciu Daniela
Published: May 2024

Cette contribution propose un aperçu des principales modifications législatives et de la jurisprudence du Tribunal fédéral [TF] de l'année 2022 en droit suisse des sociétés. La section consacrée aux modifications législatives (chiffre I) revient sur l'entrée en vigueur des modifications du Code des obligations [CO], tandis que les résumés de jurisprudence font l'objet de la section suivante (chiffre II) ; les arrêts y sont classés par forme de société et les arrêts publiés au recueil des ATF précèdent les autres arrêts, qui sont classés par ordre chronologique.
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Dieser Beitrag bietet einen Überblick über die wichtigsten Gesetzesänderungen und die Rechtsprechung des Bundesgerichts für das Jahr 2022 im Schweizer Gesellschaftsrecht. Der Abschnitt über die Gesetzesänderungen (Ziffer I) geht auf das Inkrafttreten der Änderungen des OR und anderer handelsrechtlicher Gesetze ein, während die Zusammenfassungen der Rechtsprechung Gegenstand des darauffolgenden Abschnitts (Ziffer II) sind. Die Urteile sind dort nach Gesellschaftsform geordnet und die in der amtlichen Sammlung des Bundesgerichts publizierten Leitentscheide (BGE) gehen den anderen Urteilen, die chronologisch geordnet sind, voraus.
Descubriendo el poder del juego en el proceso educativo
Authors: Torres Tovar Marlin Dayana , Chaparro Parada Luis Felipe , Beltrán Rodríguez Carlos Alirio
Published: May 2024

Las actividades lúdicas son una herramienta fundamental en el proceso de enseñanza, ya que permiten que los estudiantes aprendan de forma más amena, participativa y memorable los ejes temáticos. Al incorporar juegos y dinámicas, se puede mejorar la atención, la motivación, la creatividad y la retención de conocimientos. Es por esto, que en la universidad Santo Tomas – Tunja se ha comenzado a implementar metodologías lúdicas que contribuyan al mejoramiento del proceso formativo de los estudiantes de ingeniería Industrial, a continuación se presenta el desarrollo de la lúdica “X y Y (NEGOCIANDO CON EL ENEMIGO)” la cual fue implementada en el 10ª Encuentro de la Red Iddeal; mediante la cual se desarrollan temas asociados a la negociación, comunicación, liderazgo, trabajo en equipo y ética profesional; y se evidencia que el egoísmo en un departamento o área de trabajo puede ocasionar conflictos y dificultades con otras áreas, impactando negativamente la productividad, calidad y eficiencia del trabajo en equipo. Al participar en estos escenarios simulados, los estudiantes pueden adquirir experiencia práctica y aprender a tomar decisiones efectivas en situaciones reales. Además, al tener estos acercamientos a situaciones laborales, los estudiantes pueden comprender mejor la relevancia y aplicabilidad de los conceptos teóricos que aprenden en clase.
Understanding the General Overview of Conflict Transformation and its Dynamics in the Savannah Region of Ghana
Authors: Kapori Abutu , Gbiel Benarkuu Gabriel
Published: May 2024

From creation, conflict has since lived with mankind in all facets of life. Conflict lives with man, his environment, groups or associations. In families or marriages, conflict is deeply experienced either in the form of simple or chronic. At the workplace or the institutional level, conflict plays a key role in work operations among or between employees and employers or core management. Conflict in itself comes with positive and negative development to society. In the sovereign country like Ghana, majority of the population hold the perception or proposition that the five regions of the North are deeply rooted into conflict engagements. This perception is done to some geo-conflict occurrences in the Northern part of Ghana. The question is - what really is the term conflict? Many have divergent conceptualized views, opinions or perceptions about conflict in society. Some find answers by saying it erupts when there is argument between two or more people, when there are interests to satisfy, misunderstanding, cheating, injustice among others. Even identical twins do have conflicts. Examples of conflicts include the Kusasi – Mamprusi conflict of Bawku, Konkomba – Dagomba conflict, the Abudu – Andani Dagbon Chieftaincy conflict all of Northern Ghana and the Eritrean – Ethiopia Civil War, Rwandan Genocide, Somali Civil War, Nigerian Civil War as well as the Russia – Ukraine War.
Unveiling the Potential of Open Strategy: An Exposé of Strategic Planning in the South African Mining Sector
Authors: Gray Robert Ward , Subadra S. , Sreekala S. P
Published: May 2024

The South African mining industry, despite being the world's fifth-largest mineral reserve, is facing various challenges that prevent it from contributing to the economy to its fullest potential. These challenges include inflationary pressure, extreme nationalism, political instability, civil unrest, poor infrastructure, and inefficient regulatory practices, which have discouraged foreign investments. Although the government has developed legal frameworks to address uncertain circumstances, the lack of follow-up and transparency are key drawbacks contributing to the persistence of these issues. The aim of this study was to investigate the potential of open strategy as a strategic management method in the South African mining industry can foster innovation and growth while showcasing how open strategy can benefit both established and emerging mining entities. The study highlights the importance of adopting a mutually beneficial approach, which can unlock the full potential of the mining industry and lead to more innovative and competitive business strategies. The study used a mixed methodology, which means both quantitative and qualitative data were collected. The research included interviews with 20 highly knowledgeable participants and a survey that received 205 responses. To identify the right individuals to participate in the research, the snowball research technique was used. It helped in creating a relevant chain sampling and selecting individuals based on their knowledge, relationships, and expertise regarding the research subject. According to the study's results, there is a favorable attitude toward open strategy, which is reinforced by the growing demand for inclusive communication as an effective means of engaging stakeholders. The results also revealed that the South African mining sector lacks formalized strategies and employee engagement methods. The research determined the value of the current strategic processes in South Africa's mining sector and generated an approach to how open strategy can be a successful process for mining companies.
The Ten Business Values System Theory: A Literature-based Analysis
Authors: Wamunyima Lindunda
Published: May 2024

The study sought to contribute to the general body of knowledge and research work in business value system (BVS). The research work also aimed to establish the most prominent types of values from the literature and ascertain how BVS elements are interconnected and influence business performance toward success. The concept of business values as a system is relatively new. However, this paper’s purpose is to bridge the various pieces of BVS knowledge in literature by systematically reviewing a collection of articles on the subject and drawing valuable conclusions relating to the various paradigms or schools of thought. The researcher, for this study, identified and critically reviewed a minimum of forty (40) old and recent articles on BVS that were gathered from highly recognized and profiled research databases, including Google Scholar, Research Gate and Elsevier (database), Persistent themes on the prevalent forms of BVS; their interconnectedness and their influence on business performance were observed. It became clear that defining BVS exists because of the systematic connectedness of the values. There is enough evidence from the literature that when implemented well, BVS yields successfulness to the companies and consequently, development of the respective local and national communities in a mutual manner.
Effect of Insurance Funds on Human Development Index in Nigeria
Authors: Nwabunike Anthony Iju
Published: May 2024

The main objective of this study was to evaluate the effect of insurance funds on human development index in Nigeria between 2012 and 2022. The design adopted for this study was ex-post-factor; data used for analysis were elicited from Central Bank Statistical Bulletin, World Bank Developmental Indicators Data base and National Insurance Commission Annual Reports. To achieve this objective, a model was formulated based on empirical and theoretical reviews. The model used human development index in Nigeria as the dependent variable, while life insurance funds, pension funds and deposit administration funds were the independent variables in the model. This study employed the Fully Modified Least Squares (FMOLS) Model to analyze data.The findings elicited from this study revealed that life insurance funds and pension funds recorded significant positive effect on human development index, while deposit administration funds had a significant negative effect on human development index in Nigeria. From the inferential result, the researcher concluded that insurance funds have significant effect on human development index in Nigeria. From the foregoing, the researcher recommended that the National Insurance Commission, in conjunction with the government should efficiently work together to ensure that the premium collected, and the income generated by the industry through pension funds and life insurance are diversified into economic and productive investment, in order to boost human development in Nigeria.
Análise do perfil bacteriológico de pacientes internados em terapia intensiva quanto a morbimortalidade: Estudo longitudinal
Authors: Henrique Danielle de Mendonça , De Carvalho Andreza Moreno , Camerini Flavia Giron , Fassarella Cintia Silva , Leão Robson Souza , De Almeida Luana Ferreira
Published: May 2024

Objetivo: Analisar o perfil bacteriológico de pacientes internados em uma unidade de terapia intensiva e sua associação com a morbimortalidade. Método: Estudo observacional, longitudinal com uma amostra de 180 pacientes internados em uma unidade de terapia intensiva. A coleta de dados ocorreu por consulta ao banco de dados do laboratório de bacteriologia clínica e prontuário eletrônico entre maio e julho de 2022. O método Kaplan-Meier foi utilizado para a análise de sobrevida. Resultados: Klebsiella pneumoniae (46,38%) foi o microrganismo mais prevalente, com taxas de resistência de cefepima (90,6%), cefotaxima (84,4%), ceftazidima (84,4%), ciprofloxacino (84,4%) e piperacilina + tazobactam (84,4%). O estudo evidenciou que a cada dia de internação a chance do paciente apresentar hemocultura positiva aumentou em 4,1% (p-valor <0,001). Quanto à mortalidade, 85 pacientes foram à óbito, 34 (62,96%) com hemocultura positiva. A presença de microrganismos nas hemoculturas aumentou a chance de óbito em 2,5 vezes (p-valor 0,006). A análise de sobrevivência evidenciou os pacientes com hemocultura positiva possuem um tempo de internação mais prolongado. Conclusão: O conhecimento adequado do perfil microbiológico e de resistência antimicrobiana por enfermeiros é fundamental para orientar o planejamento e implementação de estratégias assistenciais, gerenciais e educacionais, para enfermagem e toda equipe multiprofissional.
Conhecimento popular e tradição: Uso de plantas medicinais em um quilombo no nordeste do Brasil
Authors: Filgueira Dulcilene Maria , Nascimento Rafael Pedro de Souza , Santos Helisandra dos Reis , Do Nascimento Júnior Braz José
Published: May 2024

O objetivo foi conhecer o perfil sociodemográfico e avaliar o uso de plantas medicinais na comunidade de Tijuaçu, semiárido baiano. Trata-se de uma pesquisa quantitativa, observacional, de caráter exploratório, realizada entre abril e junho de 2022. O projeto foi aprovado pelo CEP e cadastrado no SISGEN. Os dados foram coletados em questionário semiestruturado, contendo 17 perguntas. Os voluntários eram abordados nas residências e após a assinatura do TCLE, as informações eram coletadas. Os dados foram analisados por medias e frequências e a associação entre as variáveis, pelo teste qui-quadrado de Pearson. Participaram do estudo 104 informantes, dos quais 70,2% eram mulheres, 56,7% eram casados e 50% eram agricultores. 101 participantes relataram que usavam plantas medicinais. As plantas medicinais com maiores ocorrência foram: erva cidreira, capim santo e erva doce. A forma de preparo mais citada foi o chá e a parte da planta prevalentemente usada, a folha. Apesar da visível importância na manutenção da cultura identitária nesse quilombo, quanto ao uso ancestral da natureza, foram encontradas inconsistências, como o risco de interações ervas-drogas, preparos inadequados e indicações inconsistentes, colocando em risco a saúde dessas pessoas. Nesse sentido, uma capacitação para uso racional e seguro da flora na comunidade seria fundamental.
Estimating groundwater resources in an equatorial forested basin using geographic information system and remote sensing techniques (case of Nyong, South Cameroon)
Authors: Ebode Valentin Brice , Nnomo Bernadette Nka
Published: May 2024

This article aims to produce a groundwater potential zone (GWPZ) map of the Nyong basin using an integrated analytical hierarchy process driven in a geographic information system (GIS) environment. For this, seven parameters (rainfall, geology, slopes, drainage density, land use and land cover, lineament density, and soil) known to influence the availability of groundwater were considered. The results obtained show that the Eastern part of the basin holds the largest quantities of groundwater. The produced map shows that this region includes high and very high GWPZs (yield > 6 l/s). It is essentially characterized by abundant rainfall (on average 135–136 and 131–134 mm), low slopes, significant drainage and lineament densities, and significant forest cover. On the other hand, the opposite region (west), which includes the low and very low GWPZs, is characterized by less abundant precipitation (on average 121–125 and 125–128 mm), significant slopes, lower drainage and lineament densities, and greater impervious areas. With a success rate of 80%, confidence deserves to be placed in the GWPZs map produced. It can be considered in water supply projects in this basin. Such work has never been done in this basin before.
Simulation and prediction of precipitation and temperature under RCP scenarios
Authors: Chengcheng Xu , Kaixuan Guo , Jama Abdiqani Hussein , Chuiyu Lu , Qingyan Sun , Xu Li , Lingjia Yan
Published: May 2024

Climate change has an immense impact on the environment, ecology, agriculture, and economy. As the most influential climate prediction platform in the world, the Intergovernmental Panel on Climate Change provides important data on predicted future climate change trends. Based on 10 models under the RCP8.5 and RCP4.5 emission scenarios, in this study, we obtained 0.5 × 0.5° data through down-scaling data processing and predicted future rainfall and temperature changes in the Beijing–Tianjin–Hebei region of China. Combined with historical observed data of 198 meteorological stations in the region, the relationships between the predicted values of the model and the measured values were analyzed using the Taylor diagram method. The results show that (1) the future precipitation capacity assessed by the global climate system is generally higher than observed data; (2) for assessment of future temperatures, RCP8.5 shows a larger increase than RCP4.5; (3) for the Beijing–Tianjin–Hebei region, our results show that the Atmospheric Chemistry Coupled Version of Model for Interdisciplinary Research on Climate-Earth System (MIROC-ESM-CHEM) model is more consistent with the evaluation of future precipitation capacity, the Hadley Centre Global Environment Model, version 2-Earth System(HadGEM2-ES) model is more consistent with the future RCP4.5 scenario temperature evaluation, and the MIROC-ESM-CHEM model is more consistent with the future RCP8.5 scenario temperature evaluation.
Municipal sewage sludge dewatering performance enhancement by ultrasonic cavitation and advanced oxidation: A case study
Authors: Sen Tushar Kanti , Mesfin Yeneneh Anteneh , Jafary Tahereh , Al Balushi Khadija , Hong Eugene , Adewole Jimoh K. , Hamed Al Hinai Muna , Shinde Sanjay
Published: May 2024

The number of published literature on the effect of ultrasonic cavitation and advanced oxidation pretreatment on the dewatering performance of anaerobically digested sludge is very limited. This study aims at determining the optimum operating conditions of large-scale filtering centrifuges in wastewater treatment plants. The optimum dose of hydrogen peroxide, ultrasonic power, ultrasonic duration, ultrasonic pulse and particle size distribution for improved dewatering performance were determined in this study. In addition, shear stress–shear rate and viscosity–shear rate rheograms were developed to show the rheological flow properties for varying ultrasonic power and treatment duration. Optimum sonication power, time, pulse and amplitude were determined to be 14 W, 1 min, 55/5 and 20%, respectively. At a pH of 6.8, the optimum concentration of hydrogen peroxide was found to be 43.5 g/L. The optimum hydrogen peroxide dose in the combined conditioning experiments was determined to be 500 mg/L at a pH of 3. Under these optimum conditions, capillary suction time was reduced significantly by 71.1%. This study helps to reduce polymer consumption and provides the optimum pretreatment and dewatering operating conditions, and better monitoring and control in the dewatering unit has significant impact in the overall economy of wastewater treatment plants.
Microalgae cultivation trials in a membrane bioreactor operated in heterotrophic, mixotrophic, and phototrophic modes using ammonium-rich wastewater: The study of fouling
Authors: Shamskilani Mehrdad , Masojídek Jiří , Abbasiniasar Mahdi , Ganji Alireza , Shayegane Jalal , Babaei Azadeh
Published: May 2024

In this work, microalgae cultivation trials were carried out in a membrane bioreactor to investigate fouling when the cultures of Chlorellavulgaris were grown under mixotrophic, heterotrophic, and phototrophic cultivation regimes. The Chlorella cultures were cultivated in wastewater as a source of nutrients that contained a high concentration of ammonium. In mixotrophic cultivation trials, the results showed that the elevated contents of carbohydrates in the soluble microbial product and proteins in extracellular polymeric substances probably initiated membrane fouling. In this case, the highest protein content was also found in extracellular polymeric substances due to the high nitrogen removal rate. Consequently, transmembrane pressure significantly increased compared to the phototrophic and heterotrophic regimes. The data indicated that cake resistance was the main cause of fouling in all cultivations. Higher protein content in the cake layer made the membrane surface more hydrophobic, while carbohydrates had the opposite effect. Compared to a mixotrophic culture, a phototrophic culture had a larger cell size and higher hydrophobicity, leading to less membrane fouling. Based on our previous data, the highest ammonia removal rate was reached in the mixotrophic cultures; nevertheless, membrane fouling appeared to be the fundamental problem.
A IMPORTÂNCIA DA ALIMENTAÇÃO E NUTRIÇÃO PARA INDIVÍDUOS COM ENXAQUECA
Authors: Silva Ellen Cristina , Araújo Daline  Fernandes de Souza , Cunha Manuela Alves da , Bezerra Danielle Soares , Oliveira Vanessa Teixeira de Lima
Published: May 2024

Introdução: As cefaleias são consideradas um importante problema de saúde pública e estima-se que são a segunda queixa mais comum de dor, sendo a enxaqueca uma das mais presentes. O tratamento da enxaqueca pode ser sintomático ou profilático, a fim de reduzir os sintomas em períodos de crise e evitar que novas crises se instalem, destacando a importância da adoção de hábitos saudáveis e uma alimentação equilibrada. Objetivo: O objetivo deste estudo foi realizar uma revisão integrativa da literatura, destacando os principais achados sobre a importância da alimentação e nutrição para indivíduos acometidos pela enxaqueca. Metodologia: foi realizado um levantamento de estudos nas bases de dados: Biblioteca Virtual em Saúde (BVS); Medline, LILACS, SciELO e Google Acadêmico, além de ter sido considerada a lista de referências dos trabalhos consultados, utilizando a estratégia PECO, onde P (population) indica a população, a letra E (exposure) exposição, C (comparison) comparação e a letra O (outcome) se refere aos desfechos esperados, assim gerou a pergunta norteadora do estudo: “Qual é a importância da alimentação e nutrição para indivíduos com enxaqueca?”. Resultados: Foram selecionados 10 estudos para a produção do presente trabalho e foi realizada uma síntese descritiva dos resultados obtidos da relação e influência de hábitos alimentares com a enxaqueca. Conclusões: Conclui-se que os hábitos alimentares e a nutrição adequada têm grande influência e importância para indivíduos com enxaqueca, pois dessa forma, podem reduzir os sintomas apresentados e crises, já que as substâncias presentes nos alimentos estão relacionadas com o início e intensificação das crises.
ALTERAÇÕES SISTÊMICAS E BUCAIS EM PACIENTES USUÁRIOS DE COCAÍNA: UMA REVISÃO INTEGRATIVA DA LITERATURA
Authors: Nogueira Pedro Henrique , Dantas Anderson Tomaz , Lima Isabela Pinheiro Cavalcanti
Published: May 2024

Introdução: A utilização de cocaína é bastante associada ao surgimento de algumas manifestações sistêmicas e também de algumas alterações orais. Objetivo: Identificar as alterações sistêmicas e bucais mais comuns a pacientes usuários de cocaína. Metodologia: Trata-se de uma revisão sistemática da literatura, considerando artigos com texto completo, com restrição de idioma em Português ou Inglês e que tenham sido publicados entre os anos de 2017 a 2022. Usou-se as bases de dados LiLaCS, MedLine e BBO, por via portal Biblioteca Virtual de Saúde, e SciELO. Os artigos excluídos foram aqueles que não apresentaram relação explícita do uso de cocaína com alguma manifestação sistêmica e/ou bucal. Resultados: Após o processo de triagem, 10 artigos foram salvos para serem analisados e 111 foram descartados por não atenderem aos critérios de inclusão. Dos 10 artigos selecionados, 40% deles (n=4) trouxeram informações identificando possíveis riscos de desenvolvimento de doenças cardiovasculares sofridas pelos usuários de cocaína, 10% (n=1) identificou problemas cognitivos associados ao uso da cocaína, 30% dos artigos (n=3) mostrou as alterações bucais associadas à utilização abusiva de cocaína. Conclusões: Houve a predominância de algumas manifestações sistêmicas e bucais nos indivíduos usuários de cocaína, como doenças cardiovasculares, xerostomia, perfurações no palato, etc. A partir disso, há algumas alterações sistêmicas e bucais provocadas por esse uso. Mediante o risco considerável, faz-se necessário que o Cirurgião-Dentista se atualize sobre essas alterações em pacientes usuários de cocaína visando promover um trabalho transdisciplinar e multiprofissional para atender adequadamente às suas necessidades.
Palavras-Chave: Odontologia; Cocaína; Usuários de drogas; Manifestações; Cirurgião-Dentista.
VIOLÊNCIA DOMÉSTICA: A PANDEMIA DE COVID-19 PROVOCOU SUBNOTIFICAÇÃO DE CASOS E/OU AUMENTO DE SUA OCORRÊNCIA?
Authors: Belchior Giselle de Melo , Evangelista Thalya Lima , Sousa Thais Vilela de , Cardoso Diego da Costa , Vilanova Jaiane de Melo , Carvalho Filha Francidalma Soares Sousa , Moraes Filho Iel Marciano de
Published: May 2024

Introdução: O cenário pandêmico trouxe à tona e de forma potencializada alguns indicadores preocupantes acerca da violência doméstica contra a mulher. Dessa maneira, questiona-se: a pandemia de COVID-19 provocou diferença no número de ocorrências de casos de Violência Doméstica? Objetivo: Comparar a ocorrência de casos de violência doméstica contra mulheres em um estado brasileiro nos períodos de 2015 a 2018 e 2019 a 2021 segundo dados da Polícia Civil do estado. Metodologia: Trata-se de um estudo documental e descritivo, realizado com dados secundários. As informações foram colhidas através da ouvidoria da Polícia Civil em 11 de março de 2021, a partir dos registros de boletins de ocorrências policiais sobre violência doméstica contra a mulher dos anos de 2015 a 2021. Resultados: Durante os anos de 2015 a 2021 foram registrados um total de 26.671 boletins de ocorrência por violência contra a mulher. De 2015 a 2018, a média mensal foi de 360,1 ocorrências e durante a pandemia, de 2019 a 2021, a média mensal foi de 360,9 ocorrências. Notou-se um discreto aumento na quantidade de boletins de ocorrência feito durante a pandemia de COVID-19, com destaque para 2020, que apresentou média mensal de 387,4 ocorrências, período mais recrudescido da pandemia. A principal violência perpetrada foi a lesão corporal dolosa principalmente contra mulheres de 18 a 24 anos, que trabalhavam em casa ou estavam desempregadas. Conclusão: Apesar da falta de diferenças expressivas entre os anos pré e pós-pandemia, a análise reforça a urgência de discutir os fatores subjacentes à violência contra a mulher, especialmente a violência doméstica. Destaca-se a importância de medidas preventivas e de apoio às vítimas para enfrentar esse problema social. É essencial promover políticas visando uma sociedade mais segura e igualitária para todas as mulheres.
Palavras-Chave: Violência contra a mulher; Feminicídio; Violência doméstica; COVID-19.
INFILTRAÇÃO RESINOSA EM LESÕES BRANCAS CARIOSAS E NÃO CARIOSAS: RELATO DE CASOS
Authors: Araújo Isabela Dantas Torres de , Câmara Anna Cecília de Medeiros Lira , Assunção Isauremi Vieira de
Published: May 2024

Introdução: O processo de desmineralização proveniente da cárie leva à formação de manchas brancas que são a primeira manifestação visível da doença. Os infiltrantes resinosos surgem como uma alternativa para o tratamento dessas lesões não cavitadas, pois são resinas de baixa viscosidade e faz parte dos procedimentos que visam uma odontologia menos invasiva. Objetivo: Este estudo objetiva relatar a experiência clínica no uso de infiltrante resinoso (Icon) em lesões de mancha branca de etiologias cariosa e não cariosa em dois pacientes distintos, insatisfeitos com a estética do seu sorriso. Descrição do caso: Ao exame clínico foi observado nos pacientes lesões brancas. No primeiro paciente (14 anos) verificou-se a presença da atividade de cárie e micro cavitações. Dessa forma, o plano de tratamento perpassou orientação de higiene oral supervisionada, aplicação de verniz fluoretado (Enamelast) semanal, adequação do meio com restaurações em resina, e só então o uso do infiltrante. A segunda paciente (11 anos) já possuía saúde bucal adequada e tinha queixa estética devido à lesão branca não cariosa (hipoplasia), cujo plano de tratamento foi à utilização do Icon apenas. Conclusões: Nos dois casos obteve-se melhoria estética considerável com este procedimento microinvasivo. Melhoria na saúde bucal, aliado à devolução da estética, pode ser observada com o uso de infiltrantes resinosos.
ANSIEDADE, QUALIDADE DO SONO E SONOLÊNCIA DIURNA EM ESTUDANTES DE ENFERMAGEM DE UMA INSTITUIÇÃO PRIVADA
Authors: Graça José Mateus Bezerra da , Silva Filho José Adelmo da , Costa Tarciana Sampaio , Camboim Francisca Elidivânia de Farias , Rivera Giovani Amado , Oliveira Silvia Ximenes
Published: May 2024

Objetivo: Avaliar a correlação entre a ansiedade com qualidade do sono e sonolência diurna dos estudantes universitários em curso de graduação em enfermagem, assim como caracterizar o perfil sociodemográfico dos estudantes. Metodologia: Estudo descritivo transversal com abordagem quantitativa envolvendo 255 acadêmicos do curso de Enfermagem de uma instituição privada. A coleta dos dados ocorreu em Outubro de 2022 em salas de aula. Os instrumentos utilizados na coleta dos dados foram o Inventário de Ansiedade de Beck, Índice de Qualidade do Sono de Pittsburgh, Escala de Sonolência de Epwort-th e um questionário sociodemográfico. Utilizou-se o software estatístico R versão 4.0.2 e foram feitas suas correlações. Resultados: Foram encontrados padrões de ansiedade grave, com níveis de sonolência diurna anormal. A correlação entre o Inventário de Ansiedade de BECK com a Escala de Sonolência de Epworth e o Índice de Qualidade de sono de Pittsburgh, que embora tenha sido considerada fraca a moderada, por sua vez mostrou-se significativa (r=0,29; p=0,01). Ademais, temos que, a relação entre o BAI e o Índice de qualidade de sono de Pittsburgh mostrou-se também com valor de significância (r=0,35; p=0,01). Conclusões: Foi possível compreender que a ansiedade pode interferir na qualidade do sono e sonolência diurna do público de estudantes de Enfermagem.
AÇÃO DE PREVENÇÃO E COMBATE À HIPERTENSÃO ARTERIAL: UM RELATO DE EXPERIÊNCIA EM UMA LIGA ACADÊMICA DE MEDICINA
Authors: Heidemann Helena Meurer , Rosa Heitor  Fernandes
Published: May 2024

Introdução: A hipertensão arterial sistêmica (HAS) é uma das doenças crônicas de maior prevalência no Brasil, sendo essa, junto a outras doenças crônicas, o focoda atenção das unidades primárias de saúde.  Desta maneira atividades de educação em saúde relacionadas à prevenção e combate à HAS são de grande importância para reduzir a incidência dessa doença na população. Objetivo: Nesse sentido, o presente relato possui uma abordagem qualitativa descritiva exploratória, de uma experiência dos membros de uma liga acadêmica de medicina de uma universidade no Sul de Santa Catarina. Metodologia: A abordagem do público se deu através de um projeto social no ambulatório de especialidades médicas da universidade. Nesse projeto, foram distribuídos folders com informações importantes sobre hipertensão além de outras ações, como: esclarecimento de duvidas, distribuição de mudas frutíferas e frutas, aferições de pressão arterial, encaminhamentos para consultas com clínico geral e nutricionista. Resultados: A maioria das pressões arteriais aferidas estava dentro da normalidade, no entanto foram identificados alguns casos de pré-hipertensão e hipertensão ainda não diagnosticados, além de casos em que a pressão arterial estava descompensada mesmo com tratamento farmacológico, incluindo um caso de crise hipertensiva. Conclusões: Conclui-se então, que é necessária a conscientização e educação em saúde das pessoas a respeito do que é a HAS e principalmente como ter uma rotina adequada para a manutenção de uma vida saudável.
Exosomes in Atherosclerosis: Role in the Pathogenesis and Targets for Therapy
Authors: Dabravolski Siarhei , Sukhorukov Vasily N. , Glanz Victor , Pleshko Elizaveta , Orekhov Nikolay , Sobenin Igor
Published: May 2024

Atherosclerotic cardiovascular disease (ASCVD) is an advanced chronic inflammatory
disease and the leading cause of death worldwide. The pathological development
of ASCVD begins with atherosclerosis, characterised by a pathological remodelling
of the arterial wall, lipid accumulation and build-up of atheromatous plaque. As
the disease advances, it narrows the vascular lumen and limits the blood, leading to
ischaemic necrosis in coronary arteries. Exosomes are nano-sized lipid vesicles of different
origins that can carry many bioactive molecules from their parental cells, thus playing
an important role in intercellular communication. The roles of exosomes in atherosclerosis
have recently been intensively studied, advancing our understanding of the underlying
molecular mechanisms. In this review, we briefly introduce exosome biology
and then focus on the roles of exosomes of different cellular origins in atherosclerosis development
and progression, functional significance of their cargoes and physiological
impact on recipient cells. Studies have demonstrated that exosomes originating from endothelial
cells, vascular smooth muscle cells, macrophages, dendritic cells, platelets,
stem cells, adipose tissue and other sources play an important role in the atherosclerosis
development and progression by affecting cholesterol transport, inflammatory, apoptotic
and other aspects of the recipient cells' metabolism. MicroRNAs are considered the
most significant type of bioactive molecules transported by exosomes and involved in
ASCVD development. Finally, we review the current achievements and limitations associated
with the use of exosomes for the diagnosis and treatment of ASCVD.
Recent Advancement in Novel Wound Healing Therapies by Using
Antimicrobial Peptides Derived from Humans and Amphibians
Authors: Satapathy Trilochan , Kishore Yugal , Pandey Ravindra Kumar , Shukla Shiv Shankar , Bhardwaj Shiv Kumar , Gidwani Beena
Published: May 2024

The skin is the biggest organ in the human body. It is the first line of protection against
invading pathogens and the starting point for the immune system. The focus of this review is on
the use of amphibian-derived peptides and antimicrobial peptides (AMPs) in the treatment of
wound healing. When skin is injured, a chain reaction begins that includes inflammation, the formation
of new tissue, and remodelling of existing tissue to aid in the healing process. Collaborating
with non-immune cells, resident and recruited immune cells in the skin remove foreign invaders
and debris, then direct the repair and regeneration of injured host tissues. Restoration of
normal structure and function requires the healing of damaged tissues. However, a major issue
that slows wound healing is infection. AMPs are just one type of host-defense chemicals that have
developed in multicellular animals to regulate the immune response and limit microbial proliferation
in response to various types of biological or physical stress. Therefore, peptides isolated from
amphibians represent novel therapeutic tools and approaches for regenerating damaged skin. Peptides
that speed up the healing process could be used as therapeutic lead molecules in future research
into novel drugs. AMPs and amphibian-derived peptides may be endogenous mediators of
wound healing and treat non-life-threatening skin and epithelial lesions. Hence, this article describes
different peptides used in wound healing, theirmethods of preparation, and their routes of
administration.
Structural Insights of PD-1/PD-L1 Axis: An In silico Approach
Authors: Rohit Shishir , Patel Mehul , Jagtap Yogesh , Shah Umang , Patel Ashish , Patel Swayamprakash , Solanki Nilay
Published: May 2024

Background:

Interaction of PD-1 protein (present on immune T-cell) with its ligand
PD-L1 (over-expressed on cancerous cell) makes the cancerous cell survive and thrive. The association of PD-1/PD-L1 represents a classical protein-protein interaction (PPI), where receptor and ligand binding through a large flat surface. Blocking the PD-1/PDL-1 complex formation can restore the normal immune mechanism, thereby destroying cancerous cells. However, the PD-1/PDL1 interactions are only partially characterized.

Objective:

We aim to comprehend the time-dependent behavior of PD-1 upon its binding with
PD-L1.

Methods:

The current work focuses on a molecular dynamics simulation (MDs) simulation study
of apo and ligand bound PD-1.

Results:

Our simulation reveals the flexible nature of the PD-1, both in apo and bound form.
Moreover, the current study also differentiates the type of strong and weak interactions which
could be targeted to overcome the complex formation.

Conclusion:

The current article could provide a valuable structural insight about the target protein
(PD-1) and its ligand (PD-L1) which could open new opportunities in developing small molecule
inhibitors (SMIs) targeting either PD-1 or PD-L1.
Recent Trends in the Detection of Alkaloids through Analytical,
Bioanalytical, and Electrochemical Techniques
Authors: Sharma Bharat , Bhatia Rohit , Ganti Subrahmanya S , Rangra Naresh K.
Published: May 2024

Alkaloids provide significant health benefits in moderation, but excessive levels can
pose health hazards. They play an important role in the creation of numerous pharmacological
medications, acting as potent antispasmodics, analgesics, and even anti-cancer medicines. A detailed
review of sensitive and accurate alkaloid analytical techniques can be used as a guide for future
analyses of alkaloids in pertinent research. The main aim of this manuscript is to review the
literature on the detection and separation of alkaloids by using various methods like analytical, bioanalytical,
and electrochemical techniques, published during 2018-2023. An in-depth review of
the literature was carried out using a variety of databases, including Web of Knowledge, PubMed,
and Google Scholar. Consulting relevant published materials, including books, was another aspect
of this research. The keywords used in the search were alkaloids, analytical techniques, bio-analytical
techniques, electrochemical techniques, and biosensors. These were carefully examined in
more detail, and significant data and findings were collected and presented using tables. The publication
highlights the significance of advanced chromatographic techniques in the separation and
isolation of alkaloids. It discusses several analytical, bio-analytical, and electrochemical analytical
techniques, which include sensors and biosensors, and adds to the extensive review of alkaloid detection
techniques. Recent advancements and methodologies for improving the knowledge of the
detection and separation of alkaloids are presented in this article, which is beneficial for the researcher
involved in developing analytical methods for alkaloid detection. Current efforts and advanced
analytical approaches for alkaloid detection are given in this manuscript, which is crucial
in favor of improving the health and wellness of society.
Suspected Cutaneous Allergic Reactions with Ayurveda Medicine
Punaranava Mandura: A Case Report
Authors: Roseleena Suhitha , Kholiya Poonam , N Chandan , Barvaliya Manish , Siddhapur Chandrashekhar , Roy Subarna
Published: May 2024

Introduction:

With the increasing use of traditional medicine, there is a need to be
vigilant in identifying and reporting adverse reactions associated with them. Punarnava Mandura
is a commonly used Ayurvedic medicine for the treatment of anemia. It is well tolerated by the
patients. To our knowledge, allergic reactions to Punarnava Mandura have not been reported in
the literature. We reported a case of adverse cutaneous reaction, which was probably associated
with Purnarnava Mandura.

Case Presentation:

A 60-year-old female patient developed skin rashes over her neck region
after taking Punarnava Mandura and other drugs for osteoarthritis. She recovered upon
withdrawal of all the medicines and treatment with anti-allergic drugs. The patient re-initiated
treatment for joint pain except for Punarnava Mandura and completed the course without a
recurrence of the event making the Punarnava Mandura the culprit drug.

Conclusion:

Punarnava Mandura may cause allergic reactions, and clinicians should keep such
adverse reactions in mind when using traditional medicine and report them to increase the scientific literature in this area.
Differential Effects in the Subsystems of the Salience Network in Schizophrenia
Authors: Mantonakis Leonidas , Karavasilis Efstratios , Dimitrakopoulos Stefanos , Poulou Loukia S , Velonakis Georgios , Kelekis Nikolaos , Smyrnis Nikolaos
Published: May 2024

Background

Recent studies have identified links between schizophrenia and abnormalities in the brain's salience network, a crucial system with primary hubs in the anterior insula and anterior cingulate cortex. This network is divided into two subsystems: the dorsal salience network, which processes sensory information and allocates attention to self-generated or external sensory stimuli, and the ventral salience network, associated with processing the emotional valence of stimuli sensations.

Methods

This pilot study analyzed the resting state functional magnetic resonance imaging (fMRI) data from 14 schizophrenia patients and 16 healthy controls. We focused on the functional connectivity within the salience network's dorsal and ventral subsystems, particularly between the dorsal anterior insula and frontoparietal areas, and the ventral anterior insula and the subgenual anterior cingulate cortex.

Results

The analysis revealed that schizophrenia patients displayed weaker connectivity within the dorsal salience network, notably between the dorsal anterior insula and frontoparietal areas. In contrast, these patients demonstrated increased connectivity within the ventral salience system, especially between the ventral anterior insula and the subgenual anterior cingulate cortex.

Conclusion

Our findings highlight that disruptions in the salience network in schizophrenia vary depending on the type of information being processed. This variance underscores the complexity of the disorder and the specific challenges it poses to the brain's ability to process and prioritize information.
Smart Seizure Detection System: Machine Learning Based Model in Healthcare IoT
Authors: Rana Naresh , Thakur Tanishk , Jain Shruti
Published: May 2024

Background:

Epilepsy, the tendency to have recurrent seizures, can have various
causes, including brain tumors, genetics, stroke, brain injury, infections, and developmental disorders.
Epileptic seizures are usually transient events. They normally leave no trace after the postictal
recovery period has passed.

Aims:

An electroencephalogram (EEG) can only detect brain activity during the recording. It
will be detected if an epileptogenic focus or generalized abnormality is active during the recording.

Objective:

This work demonstrated a smart seizure detection system for Healthcare IoT, which is
a challenging problem of EEG data analysis.

Method:

The study suggested an integrated methodology in recognition of the drawbacks of
manual identification and the significant negative effects of uncontrollable seizures on patients'
lives.

Result:

The research shows remarkable accuracy, up to 100% in some experiments, by combining
classifier ensembles like Decision Trees, Logistic Regression, and Support Vector Machine
with different signal processing techniques like Discrete Wavelet Transform, Hjorth Parameters,
and statistical features. The results were compared using the kNN classifier, other datasets and
other state-of-the-art techniques.

Conclusion:

Healthcare IoT is further utilized by the methodology, which takes a comprehensive
approach using classifier ensembles and signal processing approaches resulting in real-time data
to help them make better decisions. This demonstrates how well the suggested method works for
smart seizure detection, which is a crucial development for better patient outcomes.
Laboratory, Clinical, and Para-clinical Symptoms of Children with Covid-19: A Gender-based Cross-Sectional Study
Authors: Nazari Javad , Kahbazi Manijeh , Taherahmadi Hassan , Amini Saeed , Zamanian Maryam , Sattari Kosar , Chazani-Sharahi Nahid , Ghafoury Roya , Naghshbandi Mobin
Published: May 2024

Background

Children show milder symptoms of COVID-19 with lower mortality rates. The manifestation of COVID-19 in the pediatric population is an understudied topic. Our aim was to investigate the clinical and para-clinical manifestations of SARS-CoV-2 in children in the Central province of Iran.

Materials and Methods

We investigated the clinical and para-clinical manifestations of children referred to all hospitals in the Central Province of Iran from March 2019 to June 2020.

Results

We surveyed 96 pediatric patients hospitalized in hospitals in the Central Province of Iran. The average age of the patients was 110 months. 53% of patients (51 people) were male. The analysis did not show a significant relationship between the laboratory results and the gender of the patients.

Conclusion

Male and female pediatric patients had the same condition in terms of clinical manifestations, laboratory results and antibiotic use.
A Brief Overview on Luminescent Recognition and Chemosensing of Carbonate
Ion
Authors: Pandey Abhilash , Banjara Dishen Kumar , Dutta Srishti , Sahu Devanand , Sharma Vanshika , Patra Goutam Kumar
Published: May 2024

Aim::

Despite the recent development of chromatographic and fluorogenic anions sensors, the hydrolysis of carbon dioxide into carbonic acid and
subsequent transformation into carbonates and bicarbonate are harmful to the environment and the health of living creatures. This is why
luminescence-based detection techniques are getting a lot of interest right now.

Background::

Despite the recent intention to create a naphthalene and triazole hybrid probe, ortho phenyl diamine (O-PDA) and two different aldehyeds have
been used in the present to successfully synthesize new fluorescent and colorimetric derivatives (AB). Aqueous solutions include colorimetrically
detectable carbonate ions. Additionally, we describe the creation and characterization of DHMC (7,8-dihydroxy-3-(4-methylphenyl)coumarin), a
new coumarin-based molecule that responds to the carbonate ion in water and acetonitrile in terms of emission turn-on and naked-eye
observability.

Object::

As part of current research, a 2:1 condensate of benzildihydrazone and syringaldehyde is being processed for the detection of carbonate ions in
aqueous solution.

Methods::

A luminescent lanthanide MOF-based thin film [{[Eu(HBPTC)(H2O)2]·2DMF}n ] (BPTC = benzophenone-3,3',4,4'-tetracarboxylate) is
successfully fabricated by electrodepositing in an anhydride system and new receptors as PDZ-1, PDZ-2, PDZ- 3 based on 2-(aryldenehydrazinyl)
pyridine have been designed and for the detection of biologically and environmentally important ions. Moreover, fluorescent-colorimetric
chemosensor which is based on a Schiff base for visual detection of CO3
2- in an aqueous solution

Results::

Many experiments were done to detect carbonate ions through various methods by using chemosensors like novel bis Schiff base, All these
methods are eco-friendly, easy to synthesize, cost-effective, naked eye detectors, and have response towards absorbance and fluorescence intensity.
It has a high binding association with carbonates. It has reversibility property. On the basis of the study and results, receptors may be useful as a
valuable practical sensor for environmental analyses of carbonate.

Conclusion::

Detection of carbonate ions through various methods by using chemosensor like novel bis Schiff base is important for product quantity control and
widely used in many daily basis products like cosmetics, glass, rayon, rubber, plastic, paper, printing ink, toothpaste and food. It has applications in
therapeutic settings as well as in the fields of soil science, hydrology, and geology. Due to the hazardous effects of these, which might include
death, collapse, vomiting, diarrhea, and stomach discomfort, it is also necessary to discover them. All of these techniques respond to absorbance
and fluorescence intensity, are cost-effective, easy to synthesize, and visible to the naked eye.