bluuebunny/crossref_metadata_2025 huggingface dataset:
AKADEMİK DİNLEME BECERİSİ YETERLİLİĞİ ÖLÇEĞİ: GEÇERLİK VE GÜVENİRLİK ÇALIŞMASI
Authors: Yıldız Sevilay
Published: March 2018

Bu çalışmanın amacı, bir "Akademik Dinleme Becerisi
Yeterliliği Ölçeği" (ADBYÖ) geliştirmektir. ADBYÖ’nin geliştirilmesi
sürecinde, ilgili literatürden yararlanılmıştır. Bu bağlamda, öğretmen
adaylarının akademik dinleme becerisi yeterlik düzeylerini tespit edebilmek
amacı ile “Aktif Dinleme Süreci”,
“Etkin Katılım”, “Dinleme Düzenlemesi” ve  “Dinleme
Kuralları” olmak üzere toplam 4 boyutlu 75 maddelik bir ölçek
oluşturulmuştur. Bu aşamadan sonra ölçek Eğitim Fakültesinde öğrenim gören
toplam 1009 öğrenciye tepkilerini almak üzere verilmiştir. Araştırma örnekleminin uygunluğu test etmek için
yapılan Kaiser-Meyer-Olkin
Değeri .87 olarak bulunmuştur. Oluşan boyutların açıklanan toplam varyans
miktarı % 44,95’dir. Ölçeğin 4 boyutunun toplam puanlar ile korelasyonu
istatistiksel açıdan .001 düzeyinde anlamlı bulunmuştur. Denemelik ölçeğin
geneli ve her boyutu için hesaplanan iç tutarlılık güvenirlikleri  (C. Alpha), 
Test-tekrar test güvenirliği yeterli bulunmuş ve üst % 27’lik ve alt %
27’lik gruplar arasında anlamlı bir fark olup olmadığını belirlemek için
yapılan bağımsız örneklem t-testi sonuçlarına göre ölçek toplam puanları ile
üst %27’lik ve alt %27’lik gruplar arasında anlamlı bir farklılık olduğu
görülmüştür.
Commentary: STS of the Underground
Authors: Birkenholtz Trevor
Published: March 2018

Geographer Trevor Birkenholtz draws out major themes across the articles in the thematic collection "Engaging the Underground: An STS Field in Formation," with reference to cartographic and model production and representation, particularly in the ways that they render the landscapes partially knowable and contestable.
Dephosphorylation using rSAP in Restriction Enzyme Reaction(M0371) v2
Authors: England Biolabs New
Published: March 2018

This protocol is for dephosphorylation of 5´-ends of DNA using rSAP in restriction enzyme reaction (M0371)
High Efficiency Transformation Protocol (C2987H) v2
Authors: England Biolabs New
Published: March 2018

This is the correct protocol if you are using the C2987H cells. If you are using the C2987I cells, please refer to this protocol.
High Efficiency Transformation Protocol using NEB 10-beta Competent E. coli (C3019H) v4
Authors: England Biolabs New
Published: March 2018

This is the correct protocol if you are using the C3019H cells. If you are using the C3019I cells, please refer to this protocol.
STUDENTS’ READING AND LISTENING COMPREHENSION BASED ON THEIR LEARNING STYLES
Authors: Magfirah Titing
Published: March 2018

This research aims to know whether there is significant difference of students’ reading and listening comprehension score based on their learning style; visual and auditory at 8th grade students of SMPN 4 Pallangga Gowa in academic year 2016-2017. This study used quantitative method and causal comparative as the design of the study. The instruments of this study were learning style questionnaire, reading comprehension test and listening comprehension test. Further, it used Independent Sample T-Test to analyze the data from learning styles questionnaire, reading and listening comprehension score. Findings of the result reveal that there is no significant difference of students’ reading and listening comprehension score based on two groups learning styles; visual and auditory. The result showed sig. value is 0.592 and 0.594 for the reading comprehension based on two learning styles; visual and auditory, are greater than p-value (0.05), (0.592 and 0.594 >0.05). Similarly, the sig. value of two learning style groups in listening comprehension performance are the same, it is 0.954. Meaning that both sig. values are greater than p-value (0.954> 0.05). Hence, it can be concluded that H0 is accepted and Ha is rejected. Clearly, from the result, it can be said that learning style was not the only one factor affecting students’ reading and listening comprehension score
PERCEPTIONS AND PRACTICES OF EFL TEACHERS IN IMPLEMENTING ACTIVE LEARNING IN ENGLISH CLASSES: THE CASE OF THREE SELECTED SECONDARY SCHOOLS IN DAWRO ZONE, SNNPRS, ETHIOPIA
Authors: Mulatu Mebratu , Bezabih Woldemariam
Published: March 2018

The purpose of this study was to investigate teachers’ perceptions and practices of active learning in EFL classrooms, in three selected secondary schools in Genna Bossa Woreda of Dawro Zone, SNNPRS. To conduct the study, descriptive survey design was employed. A total of 12 teachers and 60 students from high, medium and lower achievers were participated in the study through availability and purposive sampling technique. The study was complemented by mixed method approach that employed both qualitative and quantitative data collection tools such as observation checklists, questionnaires and interviews. The quantitative data was analyzed using frequency, percentage, mean and grand mean and the qualitative was analyzed thematically. The findings of the study revealed that most of the respondents have perceived active learning positively. In spite of their good perceptions, their practices of active learning were low/poor. The major factors affecting the effective implementation of active learning were large class size with fixed sitting arrangement, inadequate teacher training, tendency of focusing on teacher- centered method and time scarcity were among the most influential factors hindering its implementation. Finally, it is recommended that responsible bodies should rearrange the conditions and facilitate necessary inputs for the implementation.
DEVELOPING AL-QURAN INSTRUCTION MODEL THROUGH 3A (AJARI AKU AL-QURAN OR PLEASE TEACH ME AL-QURAN) TO IMPROVE STUDENTS’ ABILITY IN READING AL-QURAN AT BANDUNG ISLAMIC UNIVERSITY
Authors: Alhamuddin Alhamuddin , Hamdani Fahmi Fatwa Rosyadi Satria , Tandika Dikdik , Adwiyah Rabiatul
Published: March 2018

This research has the intention to develop the model of Quran learning which is creative and innovative to increase students’ ability in reading the Quran. This method is applied by the use of puzzle game, iqro bar, and monopoly game, so that the students can recognize the Quran letters well and correctly. This research applies the research and development approach. The trial is done to all students in every faculty at UNISBA. The number of the students who join this research is 519 students. The choosing of the samples is based on the group of students’ abilities in reading the Quran. Especially, the students who are in E group. The result of the research shows that the application of 3 A learning media for the group that hasn’t known Quran letters well correctly gives significant influence to help them recognize the Hijaiyyah letters easily. The process of learning is designed actively, creatively, effectively, innovatively and fun. This process of learning is also based on studentcentered. Based on the result, the researcher gives suggestion to do the further study as the part of the design’s development and correction of the learning Quran through 3 A media
Analysis of Policy Changing in the History of Chinese Teaching in the U.S.A.
Authors: Yanhua Meng
Published: March 2018

Based on the analysis of the language policy patterns of the U.S.A., the article combs on its history of Chinese teaching. It’s proposed that the 130 years of history can be divided into four periods according to different policy patterns. These are nonintervention policy before the Second World War, priority policy during the war, containment- priority- diversity policies after the war, and priority policy in the 21st century. Based on these analyses, a revised policy pattern mode is provided for analyzing foreign language policy.
Experience the Truth According to Heart: An Analysis of Kien Minagawa’s Reflection Sixth in the Abstract of Inquiry and Study
Authors: Heng Shen
Published: March 2018

Kien Minagawa is a Sinologist in Japanese Tokchon middle age. Abstract of Inquiry and Study is the learning principal of Kien Minagawa, which containing Six Clauses and Thirty Subclauses. Reflection is the last step of Six Clauses, and it is not only the end and summary of the article, but also the beginning of learning. Reflection contains three stages: observing, thinking and practise, which depend on each other. The three stages of Reflection are the study of the subtle relationship between knowledge and practice, and also the learning for oneself.
Black Educational Leadership: The State of the Art in Ontario Elementary Schools
Authors: Trought-Pitters Evra
Published: March 2018

The current educational system upholds principles and practices that covertly support institutionalized oppression while affirming and legitimizing privilege and entitlement for students, teachers, and administrators who emulate the cultural capital of the dominant Western culture. This systematic literature review, explored ways in which Black leaders have enacted social justice education in Ontario elementary schools from 1970 to 2017. I have searched six academic databases, peer reviewed journals, the media, academic and professional articles and used close reading and textual analysis to critique Social Justice Leadership discourses. Barriers still exist to Black students’ progress. More research is needed for meaningful social change
A Multicultural Education Praxis: Integrating Past and Present, Living Theories, and Practice
Authors: Shannon-Baker Peggy
Published: March 2018

In our current climate of heightened conservatism and criticism, multicultural education is as important as ever. This article argues for the need to reframe multicultural education as a praxis based on its social justice- oriented principles, values, and practices. Using practitioner action research, I examine my implementation of such a praxis in a college course. I discuss critical reflections on demonstrating the interconnections between current and historical social movements, theory and lived experiences, and the students’ and my learning. I conclude by arguing that reframing multicultural education as a praxis could encourage more coalitions within and beyond schools.
Ensino de língua inglesa: síntese ou invasão cultural?
Authors: Stocovichi Sandra Regina Cibin , Sousa Fabiana Rodrigues de
Published: March 2018

O ensino de língua inglesa como uma atividade neutra é reflexo de um discurso marcado pelo colonialismo, que traz em seu bojo uma hierarquização cultural que divide os seres humanos entre os falantes da língua inglesa (tidos como superiores) e aqueles que se expressam em sua língua (percebidos como inferiores). Com intenção de questionar essa abordagem que legitima o ensino de língua inglesa como forma de invasão cultural, este artigo apresenta reflexões tecidas ao longo de pesquisa de mestrado em Educação, cujo objetivo foi analisar a possibilidade de o ensino de língua inglesa se configurar como síntese cultural, isto é, como espaço para produção de contra discursos. Palavras-chave: Língua inglesa. Síntese cultural. Educação popular.Teaching english: synthesis or cultural AbstractTeaching English language as something neutral reflects a speech marked by colonialism that brings with it a cultural hierarchy that divides human beings among native speakers (taken as superior) and those that are expressed in their mother tongue (perceived as inferior). Intended to question this approach legitimizes the teaching of English as a form of cultural invasion, this article presents reflections done throughout master's research in education that aimed to analyze the possibility of English language teaching to set yourself up as a cultural synthesis that is, as a space for production counterdiscourses.Keywords: English language. Cultural synthesis. Popular education.
Juventude(s) negra e a reprodução das desigualdades raciais no Brasil: políticas públicas de igualdade?
Authors: De Ataide Marlene Almeida
Published: March 2018

O presente artigo tem como objetivo refletir criticamente acerca da categoria juventude negra que vive em condições precárias e que permanece à margem da sociedade, pois encontra dificuldades para existir como sujeitos de direitos no que se refere à inclusão no âmbito das políticas públicas consagradas de direitos, pois essas atuam de costas para esses jovens. Parte-se do pressuposto de que o racismo e as desigualdades sociais se constituem nos principais fatores que influenciam e que atingem principalmente as juventudes negras e pobres expressas a partir da segregação sócio-espacial, da discriminação racial e da vivência de pobreza. Os jovens afrodescendentes, além de vivenciarem as dificuldades tradicionais impostas socialmente, encontram barreiras adicionais devido às relações sociorraciais brasileiras. Assim, neste artigo, busca-se um espaço de reflexão, partindo do princípio de que as políticas públicas de cunho universalista têm um papel importante na redução da pobreza, porém limitado no combate à desigualdade racial. Em decorrência disso, somente com a adoção de políticas específicas é que se logrará reverter o quadro da iniquidade racial. Um dos grandes desafios que se impõe ao Estado brasileiro é de criar condições mais igualitárias para a inclusão de jovens no âmbito das políticas públicas de direitos que se destinam a eles.Palavras chave: Juventude. Juventude negra. Desigualdades raciais. Políticas públicas.Black youth(s) and the reproduction of racial inequalities in Brazil: public policies for equality? AbstractThis article aims to reflect critically about black youth category living in poor conditions and remain on the margins of society, for they find it difficult to exist as subjects of rights with regard to the inclusion in the scope of the dedicated public rights policies because they operate with his back to these young people. This is on the assumption that racism and social inequality constitute the main factors that influence and primarily affects poor black youths expressed from the socio-spatial segregation, racial discrimination and poverty of experience The young African descent as well as experience traditional difficulties imposed socially; are additional barriers due to the Brazilian socio-racial relations. So in this article, we seek a space for reflection, assuming that public policies of universal nature play an important role in reducing poverty, but limited in combating racial inequality; as a result, only with the adoption of specific policies is that it will achieve reverse the situation of racial inequality. A major challenge that requires the Brazilian government is towards creating more equal conditions for the inclusion of young people within the public policy of rights that are meant to them.Keywords: Youth. Black youth. Racial inequalities. Public policy.
"Ciência Cover" em ciências humanas e ciências sociais na América Latina
Authors: Maerk Johannes
Published: March 2018

Este pequeno ensaio trata de analisar o porquê de haver uma longa tradição nas ciências humanas e sociais na América Latina de importar, indiscriminadamente, teorias e conceitos dos países do Norte. Chamamos “Ciência Cover” a atitude de copiar os conceitos estranhos à realidade social latino-americana. Ao mesmo tempo, há esforços importantes de elaboração própria, como a teoria da dependência, a sociologia da exploração e o conceito de "imperialismo interno", que apontam para uma autêntica construção latino-americana de conhecimento.Palavras-chave: Ciência Cover. América Latina. Teoria da independência. Sociologia da exploração. Imperialismo interno."Science Cover" in Humanities and social sciences in Latin AmericaAbstractThis small essay tries to analyze why there is a long tradition in Latin American humanities and social sciences to import theories and concepts from the countries of the North. I call “cover science” an attitude of importing ideas and concepts from other regions and of applying them indiscriminately to local social realities. At the same time, there are important efforts of authentic Latin American knowledge construction such as dependency theory, the sociology of exploitation or the concept of "internal imperialism”.Keywords: Science cover. Latin America. Theory of independence. Sociology of exploration. Internal imperialism.
Objetos de aprendizagem e alfabetização: uma proposta de uso de recursos lúdicos para crianças com dificuldades de aprendizagem
Authors: Fiscarelli Silvio Henrique , Morgado Camila Lourenço , Uehara Flavia Maria
Published: March 2018

Este trabalho apresenta os resultados parciais de uma pesquisa, em andamento, que tem por objetivo investigar o uso de Objetos de Aprendizagem (OA) como recursos de apoio a crianças com dificuldade no processo de alfabetização nos anos iniciais do Ensino Fundamental. A investigação busca verificar se o uso do referido recurso tecnológico pode ajudar na superação de dificuldades de aprendizagem diagnosticadas em sala de aula e que se referem ao processo de alfabetização. A pesquisa procura explorar algumas características dos OA, que possibilitam apresentar conteúdos curriculares de uma maneira lúdica e a partir de práticas educativas realizadas fora do ambiente escolar. Embora a investigação ainda esteja em andamento, os resultados obtidos até o momento apontam que os alunos que participaram das atividades com OA conseguiram superar algumas dificuldades de aprendizagem e obtiveram melhor desempenho nas avaliações diagnósticas.Palavras-chave: Objetos de aprendizagem. Alfabetização. Dificuldades de aprendizagem. Learning and literacy objects: a proposal to use playful resources for children with learning difficultiesThis paper presents the partial results of in progress research that aims to investigate the use of Learning Objects (LO) as resources to support students with difficulties in the literacy process in the initial years of Elementary Education. The goals of research is verify if the use of this technological resource, outside of school environment, can help the students to surpass difficulties in the literacy process diagnosed in the classroom. The research explore some characteristics of the technological resources, in this specific case, the characteristics of Learning Objects, that allow presenting curricular contents in a playful way and alternative practices for learning. Although the research is still in progress, the outcomes obtained at the moment indicate that students who participated in activities with LO have surpass some learning difficulties and obtained a better classification in the diagnostic evaluations.Keywords: Learning Objects. Literacy. Learning Disabilities.
Реализация инновационных проектов как основа экономического развития
Authors: Загидуллина Гульсина Мансуровна , Зайнуллина Диляра Рамилевна , Мавлютова Алина Равилевна , Сиразетдинова Эвелина Рустемовна
Published: March 2018

Объектом исследования настоящей статьи является инновационное проектирование. В качестве цели исследования выступает изучение теоретических основ экономического развития за счёт реализации инновационных проектов, для достижения которой применялся теоретический анализ, в частности рассмотрение терминов. В результате была разработана схема процесса инновационного проектирования, дополнены известные отличия инвестиционных и инновационных проектов, сформулированы теоретические предпосылки инновационного развития хозяйствующих субъектов.
Особенности оценки рыночной стоимости объектов культурного наследия
Authors: Сиразетдинов Рустем Маратович , Пукита Алеся Геннадьевна
Published: March 2018

Объекты культурного наследия выделяются среди прочих объектов недвижимости и обладают целым рядом особенностей. Поэтому при оценке таких объектов следует особое внимание уделить построению методики расчета.
Целью исследования является выявление существующих методик, их преимуществ и недостатков, анализ их применимости и соответствия рыночной практике.
Данное исследование построено на сопоставлении рыночных и расчетных данных вклада нематериального фактора, отличающего объекты культурного наследия от обычных объектов недвижимости и приводящего к увеличению стоимости.
Результаты исследования показали ряд несоответствий расчетных и реальных рыночных данных. Часть коэффициентов нематериального фактора помимо увеличения стоимости также приводят к увеличению обременения для собственника.
Поэтому при использовании существующих методик необходим их анализ на соответствие рыночным данным и применимости к оцениваемому объекту.
Оценка деловой репутации компании
Authors: Устинова Лилия Нурулловна , Рожков Вадим Львович
Published: March 2018

В настоящее время среди руководителей высшего уровня все чаще стала возникать необходимость учета и оценки активов, которые не обладают материально- вещественной формой, но также как и материальный активы способные приносить благо компании. Поэтому, очевидно, что неимущественные активы также существенно могут влиять на стоимость компании, рост стоимости ценных бумаг, уровень доверия инвесторов. Деловая репутация компании является ее нематериальным активом, она может оказывать значительное влияние на устойчивость и благоприятное развитие компании в том случае, если ею правильно управлять.
В статье использовались инструменты комплексного анализа: компилятивный, системный, статистический, критический и аналитический подходы.
Результатом проведенного исследования стал комплексный подход к оценке деловой репутации.
Ценностью представленной статьи в практическом применении является использования предложенного подхода к оценке деловой репутации для возможности повышения стоимости предприятия в целом в ряде отдельных случаев.
Инновационный потенциал предприятия: сущность, структура, оценка
Authors: Устинова Лилия Нурулловна , Сиразетдинов Рустем Маратович
Published: March 2018

Тенденции формирования постиндустриального пространства диктуют необходимость поиска путей развития и роста ресурсной составляющей производства. Многие исследователи вопроса управления и развития инновационного потенциала рассматривают его как ключевой элемент построения многогранной сложной и устойчивой структуры. Инновация как понятие активно развивается как среди экономистов, теоретиков, исследователей, так и среди производственников, политиков, представителей бизнес - элиты, это термин, который получил широкую огласку с конца 19 века и посей день, является актуальным.
В статье использовались методы и инструменты, позволяющие проводить комплексный анализ на основе систематизации и структурирования тематического материала: компилятивный, системный, а также избирательный, статистический, критический и аналитический подходы.
Результатом проведенного исследования стали выводы относительно сущности и особенностей инновационного потенциала предприятия, которые представляют собой результат систематизации и обобщения ранее исследуемых параметров и критериев оценки инновационного потенциала.
Ценностью представленной статьи в практическом применении является возможность выбора наиболее объективного метода оценки инновационного потенциала предприятия, из представленных в статье.
Применение высокоэффективных теплоизоляционных материалов как основа энерго- и ресурсосбережения на всех стадиях жизненного цикла объекта недвижимости: тенденции, анализ, расчеты
Authors: Крашенинникова Алина Равилевна , Масленников Даниил Ниязович
Published: March 2018

Предлагаемая статья посвящена актуальной теме развития ресурсосберегающих технологий и повышения показателей энергоэффективности и энергосбережения строительного комплекса современной России, разумного, экономически обоснованного использования всех видов энергоресурсов, сокращения отходов и выбросов в процессе проектирования, строительства, эксплуатации строительных объектов в течение всего жизненного цикла их существования.
В работе произведен краткий анализ этапов жизненного цикла здания с позиции инвестирования в энергосбережение, и определены его энергетические взаимосвязи в воспроизводственном процессе в соответствии со спецификой каждого этапа. Рассмотрены основные пути достижения энергоэффективности будущего здания на стадии проектирования, подробно рассмотрены особенности вариантного проектирования энергосбережения в части повышения теплозащитных свойств наружных ограждающих конструкций (на примере утепления наружных стен жилого здания с применением двух вариантов утеплителей - стекловолокнистых и базальтовых). По результатам расчетов и по совокупности характеристик выбран наиболее эффективный утеплитель.
Результаты работы могут быть полезны инженерам-проектировщикам, девелоперам и другим специалистам строительного комплекса, а также потенциальным правообладателям различных объектов недвижимости.
Комплексное развитие территорий: цели, ресурсы и показатели эффективности
Authors: Гареев Ильнур Фаилович , Мухаметова Наиля Назыймовна
Published: March 2018

Статья раскрывает проблемы, препятствующие развитию сельских территорий, в контексте соответствия причин их возникновения и предпринимаемых действий для устранения данных негативных тенденций. В результате проведенного исследования первичная гипотеза о необходимости определения владельцев процесса развития сельских территорий и наделения их необходимыми полномочиями трансформировалась в новую гипотезу о потенциале сельских сообществ стать новым владельцем процесса развития сельских территорий.
Christ Would Break Your Tongue
Authors: Stewart Sheila
Published: March 2018

“Christ Would Break Your Tongue” is part of my on-going exploration of growing up as a United Church minister’s daughter in small-town Ontario. In the title poem, I inquire into the interstices of gender, voice, and authority. In “Dominion” I grapple with how the Christian underpinnings of Western culture place humans above other creatures and lifeforms to the detriment of all living beings. In “Billy Stewart’s Geography” I begin to explore the church’s role in political oppression, colonialism, and residential schools, building on my poetic interests in family dynamics and place (Stewart, 2003; 2012). I use poetic inquiry (Butler-Kisber, Guiney Yallop, Stewart, & Wiebe, 2017; Faulkner, 2009; Galvin & Prendergast, 2016; Prendergast, Leggo, & Sameshima, 2009; Thomas, Cole, & Stewart, 2012) as a research method to reflect on and through language, letting the poems be the plumb-line of the research process. Poetry’s use of the associative, the particular, and the unconscious allow me to explore terrain which may have been previously un-worded. This is needed to write through shame and grief. I believe with Orr (2002) that “the more of our own stories that we can tell, the richer and more complex our selves become. The richer a use we make of our past experience, the more open we are to present experience” (p. 102). This openness is crucial in the search for word and action. Educator Maxine Greene (1977) calls us to be open or “awake.” How can poets be awake to this complex social/political moment and use their craft to speak? Poetry works with stories and lyric which are once personal, ideological and often shaped by religion. As a white settler Canadian, I strive to uncover the complicity of my religious and Northern Irish background in hierarchical and oppressive relations. My hope is to provoke.
In Endothelial Cells, the Activation or Stimulation of Soluble Guanylyl Cyclase Induces the Nitric Oxide Production by a Mechanism Dependent of Nitric Oxide Synthase Activation
Authors: Martinelli Ariane Migliato , Rodrigues Carla Nascimento dos Santos , Moraes Thiago Francisco de , Rodrigues Gerson Jhonatan
Published: March 2018

Purpose. In endothelial cells, investigate if the soluble guanylate cyclase (sGC) activation or stimulation is able to potentiate the relaxation in vessels. Methods. Aortic and coronary rings with and without endothelium were placed in a myograph and cumulative concentration-effect curves for DETA-NO or ataciguat were performed. Nitric oxide (NO) were measured by fluorescence or by selective electrode in human umbilical endothelial cells (HUVECs) in response to some treatments, including ataciguat, 8-Br-cGMP and A23187. Results. The presence of the endothelium potentiated the relaxation induced by DETA-NO in aortic and coronary rings. In addition, in aortic rings the endothelium potentiated the relaxation induced by ataciguat. In the presence of nitric oxide synthase (NOS) inhibitor, the endothelium effect was abolished to DETA-NO or ataciguat, in both vessels. Ataciguat, 8-Br-cGMP and A23187 were able to induce NO production in HUVECs cells. In the presence of NOS inhibitor, the NO production induced by ataciguat and 8-Br-cGMP was abolished. Conclusions. Our results suggest that in aortic and coronary rings the endothelium potentiates the relaxation induced by activation or stimulation of sGC through a mechanism dependent of NOS activation. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Microneedles as Enhancer of Drug Absorption Through the Skin and Applications in Medicine and Cosmetology
Authors: Serrano-Castañeda Pablo , Escobar-Chavez Jose Juan , Rodriguez-cruz Isabel Marlen , Melgoza Luz Maria , Martinez-Hernandez Jessica
Published: March 2018

The microneedles technology has found applications in many health-related fields. For example, their application in drugs and vaccines delivery as well, as the determination of biomarkers, has been reported. They also have a place in the dermatology and cosmetic areas such as the treatment of wounds from burns, scars, acne, depigmentation, and alopecia will be shown. Microneedles are used in therapeutic applications and are manufactured using materials such as metal (steel, titanium, nickel), polymer (oly-glycolic acid (PGA), poly-lactide-co-glycolide acid (PLGA), poly-L-lactic acid (PLA), chitosan), glass, silicon, ceramic, carbohydrates (trehalose, sucrose, mannitol). Examples of application of microneedles and their advantages and disadvantages are discussed. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Analysis of patients with hypomagnesemia using the Japanese Adverse Drug Event Report database (JADER)
Authors: Tanaka Hiroyuki , Yoshiba Yuka , Watanabe Tomoko , Satoh Mitsutoshi , Ishii Toshihiro
Published: March 2018

Summary – Purpose. In order to clarify the occurrence of hypomagnesemia in Japan, we conducted a database search and analysis using the Japanese Adverse Drug Event Report database (JADER). Methods. Among the cases recorded in JADER between April 2004 and December 2015, we targeted “hypomagnesemia” and analyzed the patients’ backgrounds, drug involvement, other adverse events reported with hypomagnesemia, the time of hypomagnesemia onset, outcomes, and year when reported. For drugs with three or more reports, the signal index was calculated using the Reporting Odds Ratio (ROR) method. In addition, the association between hypomagnesemia onset and other adverse events was investigated using association analysis. Results. The total number of reported hypomagnesemia cases was 201. Males accounted for 62.7%, and patients in their sixties formed a large peak. Three or more cases were reported for 23 causative drugs, among which anti-EGFR antibody, calcineurin inhibitor, platinum antitumor agent and proton pump inhibitor accounted for the majority. ROR analysis detected signals for 18 drugs, and an association was found between hypomagnesemia and other electrolyte abnormalities for those drugs. The median time until onset of hypomagnesemia was classified into three patterns: around 10 days, around 30 days, and longer. Analysis of the report year revealed an increasing tendency in recent years, although increases/decreases were evident depending on fiscal years. Conclusion. Our survey was able to reveal the factors associated with the occurrence of hypomagnesemia.
Evaluation of the Benefits of De-Escalation for Patients with Sepsis in the Emergency Intensive Care Unit
Authors: Niimura Takahiro , Zamami Yoshito , Imai Toru , Nagao Kanako , Kayano Masafumi , Sagara Hidenori , Goda Mitsuhiro , Okada Naoto , Chuma Masayuki , Takechi Kenshi , Imanishi Masaki , Koyama Toshihiro , Koga Tadashi , Nakura Hironori , Sendo Toshiaki , Ishizawa Keisuke
Published: March 2018

Purpose. Although the 2016 Japanese guidelines for the management of sepsis recommend de-escalation of treatment after identification of the causative pathogen, adherence to this practice remain unknown. The objective of this study was to evaluate the benefits of de-escalating treatment for sepsis patients at an advanced critical care and emergency medical centre. Methods. Based on electronic patient information, 85 patients who were transported to the centre by ambulance, and diagnosed with sepsis between January 2008 and September 2013 were enrolled and evaluated. Patients were divided into two groups with and without de-escalation, and comparisons were conducted for several variables, including length of hospital stay, and length of antibiotic administration. Two types of subgroup analysis were conducted between patients with septic shock or positive blood cultures. Statistical analysis was conducted using chi-square and Mann-Whitney U tests. Results. The length of hospital stay after diagnosis was significantly shorter for the de-escalation group than for the non-de-escalation group. In the subgroup analysis, de-escalation for blood culture-positive patients was beneficial in terms of the length of hospital stay and length of antibiotic administration. Conclusions. The findings of this study suggest that sepsis treatment de-escalation is beneficial for treatment efficacy and appropriate use of antibiotics. This article is open to POST-PUBLICATION REVIEW. Registered readers (see “For Readers”) may comment by clicking on ABSTRACT on the issue’s contents page.
Türkiye Muhasebe ve Finansal Raporlama Standartları Konusunda Üniversite Öğrencilerinin Algı Düzeylerinin Ölçülmesi: Bilecik Şeyh Edebali Üniversitesi Örneği
Authors: Fidan Meral Erol , Uysal Taner
Published: March 2018

Küreselleşen günümüz ortamında, işletmelerin varlıklarını sürdürebilmeleri için aynı dili konuşmaları gerekmektedir. Aynı dili konuşmanın yolu ise Uluslararası Muhasebe Standartları’nı uygulamakla sağlanabilmektedir. Ülkemizde standartlara uyumlaştırma çalışmaları sonucu muhasebe uygulamaları ile mevcut muhasebe uygulamaları arasında farklılıklar oluşmaktadır. Meslek adaylarının bu farklılıklar hakkında bilinçlendirilmesi gerekmektedir. Bu nedenle, muhasebe meslek adaylarının söz konusu standartlar hakkında bilgi sahibi olmaları önem arz etmektedir. Yapılan araştırma sonucunda, 20 yaş ve altı ile 21 yaş ve üstü üniversite öğrencileri arasında; işletme, uygulamalı bilimler ve muhasebe ve vergi uygulamaları bölümleri arasında; 2. sınıflarla 3. ve 4. sınıflar arasında; staj yapmış ve yapmamış öğrenciler arasında muhasebe standartlarını algılamaları bakımından istatistiki açıdan anlamlı farklılıklar olduğu tespit edilmiştir. Öğrenciler aldıkları muhasebe derslerinde TMS/TFRS’lerden az da olsa bahsedildiğini belirtmekle beraber, genel muhasebe dersini almış öğrencilerin kendi çabalarıyla muhasebe standartlarını öğrenebileceklerine katılmadıkları tespit edilmiştir. Ayrıca öğrencilerin derslerde TMS/TFRS’ler hakkında daha fazla uygulama yapılması gerektiği düşüncesinde oldukları tespit edilmiştir.
Osmaniye, Düziçi Ağzından Derleme Sözlüğü'ne Katkılar-2
Authors: Demirci Metin
Published: March 2018

Dil çalışmalarının önemli bir alanı da ağız çalışmalarıdır. Türkiye Türkçesiyle ilgili ilk ağız çalışmaları hemen hemen 19. yüzyılın ikinci yarısına kadar gitmektedir. O zamandan bu zamana ağız çalışmaları hem nicelik olarak hem de nitelik olarak belli bir safhaya gelmiştir ancak çalışılan ağızların yanında henüz tam olarak çalışılmamış, özellikleri belirlenmemiş, diğer ağızlarla benzerlikleri ve farklılıkları tespit edilmemiş ya da çalışılan ağız içinde asıl yeri belirtilmemiş yöreler de vardır. Bu kabil yerlerden biri de Düziçi'dir. Bu çalışmada Osmaniye Düziçi ağzından Derleme Sözlüğü'ne katkı sağlanacaktır. Bu çalışmada değerlendirilen söz varlıkları Osmaniye, Düziçi ilçesinden yaklaşık on yıldır çeşitli zaman ve mekȃnlarda sohbet esnasında not alınan, anlamları sorulan ve kaydedilen kelimelerdir. Burada verilen kelimelerin çoğu aynı zamanda makale yazarı tarafından da bilinen, birçoğu da çevresindeki insanlar tarafından hȃlȃ konuşma dilinde canlı bir şekilde kullanılan sözlerdir. Ancak elde edilen kelimeler sayıca fazla olduğu için iki yayın şeklinde değerlendirilmesi uygun görülmüştür. Önceki çalışmada "I"ya kadar olan kelimeler ve anlamları verilmiştir. Bu çalışmada ise "I-Z" ve arası söz varlıkları değerlendirilmiştir. Bu çalışmada Derleme Sözlüğü'nde de olan ancak farklı anlam ifade eden kelimeler italik olarak verilmiştir.
Atatürk İlkeleri Türk Milletine Neler Kazandırdı?
Authors: Uca Alaattin
Published: March 2018

Atatürk ilkeleri Türk milletinin birlik ve beraberliğini sağlayan en önemli unsurlardan biridir. Cumhuriyetçilik, Milliyetçilik, Halkçılık, Laiklik, Devletçilik ve İnkılâpçılık olarak nitelendirilen bu kavramların hepsi Türk milletinin çimentosu ve harcıdır. Bunların her biri Türk milletinin dünyada saygın toplumlar arasında yer almasına katkıda bulunmuştur. Atatürk ilkeleri sayesinde Türk milleti çağdaş bir toplum olmuştur. Bu ilkeler doğrultusunda yeni bir devlet kurulmuştur. Türkiye Cumhuriyeti adıyla kurulan bu devlet çağdaş, demokratik, laik ve sosyal bir hukuk devletidir. Türkiye’de millet kendi kendini yönetmektedir. Irkçılık yoktur. Türk milleti sınıfsızdır. Dini inançlardan dolayı insanlar arasında ayrım yapılmaz. Devlet ekonomik faaliyetlere katılır ve özel sektörü de korur. Türk milleti yeniliklere açıktır. Bu ülkenin sınırları içinde yaşayan bütün insanlar hür ve eşittir. Bunları Atatürk ilkeleri sağlamıştır. 
Licenciatura em matemática e o percurso de estudo e pesquisa: uma proposta do modelo epistemológico de referência para o ensino e aprendizagem do conceito de função
Authors: Rodrigues Rochelande Felipe , Menezes Marcus Bessa de , Santos Marcelo Câmara dos
Published: March 2018

O referido trabalho é sobre o Percurso de Estudo e Pesquisa (PEP), um dispositivo didático que pode ser utilizado como metodologia para o ensino e aprendizagem dos conceitos matemáticos nas licenciaturas em Matemática. O PEP tem como base teórica a Teoria Antropológica do Didático (TAD), tendo Yves Chevallard como o seu principal representante. Também utilizamos a noção de Contrato Didático (CD) de Guy Brousseau, que traz elementos importantes de análise dos encaminhamentos do PEP, ressaltando as rupturas no processo. A proposta de aplicação do PEP será por meio do conteúdo de Função, um importante conteúdo da Educação Básica e da Educação Superior. O trabalho apresenta alguns pontos de ligação entre o CD e o PEP, que podem identificar algumas dificuldades na implementação do dispositivo didático, principalmente na mudança de contrato didático já estabelecido para um novo contrato, dificultando as possíveis rupturas e ocasionando outras dificuldades. Outro ponto é a utilização do PEP para apresentar outra maneira de trabalhar os conceitos matemáticos nas licenciaturas em Matemática.
Percepções de professores de Química do nível médio sobre problema e exercício
Authors: Freitas Amanda Pereira de , Campos Angela Fernandes
Published: March 2018

A presente pesquisa relata uma investigação com professores de Química do ensino médio das escolas públicas de Recife-PE,que teve por objetivo identificar e analisar as percepções desses docentes acerca dos termos problema e exercício. Para tanto, foi realizada uma entrevista semiestruturada com cada docente, a qual mediada por um questionário. O tratamento dos dados foi realizado à luz da Análise de conteúdo proposta por Bardin. Os resultados mostraram que a maioria dos professores tem uma visão simplista acerca de problema não levando em consideração alguns aspectos que são inerentes a um problema. Apenas dois docentes apresentaram uma visão mais ampla sobre problema, considerando o seu ponto de vista metodológico. Além disto, os sujeitos possuem uma percepção inadequada sobre problema e exercício apresentando confusão em relação a distinção destes termos.  Em contrapartida, a percepção apresentada pela maior parte dos sujeitos sobre exercício corrobora com as ideias de autores da área de resolução de problemas. O estudo sugere proposição de formação continuada que envolva reflexões sobre o ensino e aprendizagem baseado na resolução de problemas.
The experience of anesthesia during kidney transplantation with robot assisted laparoscopic surgery
Authors: Tekdöş Şeker Yasemin , Saygı Emir Nalan , Hergünsel Oya , Tülübaş Evrim , Öztürk Figen , Mandacı Derya
Published: March 2018

Objective: Renal transplantation is the most commonly
used method to improve the quality of life of patients with end-stage renal
failure. Kidney transplantation began in our hospital in 2016 with
robot-assisted laparoscopic surgery (RALS). Here, we retrospectively compared
the RALS technique and open surgery with respect to anesthesia management
during kidney transplant operations done in our clinic. Methods: Anesthesia
management, the duration of the operation and of vascular anastomosis, the
amount of fluid delivered perioperatively, amount of urine, and diuretic
requirements were investigated retrospectively in cases of renal
transplantation (Group O, open surgical technique, n = 22; Group R, RALS technique, n = 14). Blood gas values, and lactate, bicarbonate,
glucose, and electrolyte levels, were examined preoperatively after extubation.
Results:
The durations of surgery and vascular anastomosis were significantly longer in
Group R than in Group O (p < 0.05).
Perioperative liquid volume was not significantly different between Groups R
and A. Postoperative systolic arterial pressure was significantly higher in
Group R than in Group O. As venous blood samples were obtained in Group O and
arterial blood samples were obtained in Group R, blood gas parameters were
evaluated within, but not between, groups. The pH and HCO3 values at
the end of the operation were significantly lower, while the lactate level was
significantly higher, in Group O compared to Group R (p < 0.001). There was a significant decrease in calcium level at
the end of the operation versus pre-anesthesia induction in Group O, but no
significant increase in the glucose level was found. There were no significant
differences in sodium or potassium levels within or between the groups (p > 0.05). Conclusions: The surgical superiority of RALS technique is known.
However, anesthesia management in this patient group is difficult due to the
risk of the Trendelenburg position and pneumoperitoneum.
Synchronisation of Price Cycles in European Housing Markets
Authors: Żelazowski Konrad
Published: March 2018

The housing market plays a crucial role in every economy. Its importance is determined not only by the size of the housing sector but also by the number of socio‑economic functions of residential properties. Just as any other market or economy in general, the housing sector develops cyclically. Housing cycles were traditionally considered to be driven by domestic factors. However Economic integration among the countries of the European Union has fostered a general tendency towards synchronisation of national housing cycles. The aim of the research was to identify the properties of housing cycles in selected European countries as well as to verify the degree of their synchronisation. The study covered residential markets in Belgium, France, Holland, Germany, Great Britain, and Italy in the years 1971–2014. The Christiano‑Fitzgerald filter was used to isolate price cycles, while correlation coefficients and the concordance index were used to assess synchronisation. The obtained results confirmed the occurrence of the phenomenon of synchronisation of housing cycles. Its intensity increased at the end of the 1990s, and one of the main causes for this increase was the introduction of a single European currency and the accompanying convergence of financial markets.
Capital Market Union – Perspectives on Changes in the Financial System Model in the European Union
Authors: Janicka Małgorzata Anna
Published: March 2018

Currently the EU is working on the building of the so‑called Capital Markets Union. The undertaken restructuring of the financing model is designed to make a shift in the main channel through which enterprises raise investment funds, from loans to capital, and – as a result – contribute to more dynamic growth in the EU Member States. So far, the key problem with insufficient dynamics of Economic growth in the EU seems to stem not so much from the structure of investment financing but from mechanisms of the euro zone, which economically polarise its members. The European Union should, first and foremost, thoroughly analyse and reformulate the constituting principles of the euro zone, instead of making another attempt to deepen capital markets integration and changing the financing model dominant in the EU Member States. The objective of the paper is to analyse conditions and rationale of the shift in the role which the banking sector plays in transferring investment resources for the benefit of the European Union capital markets (intensification of disintermediation). Conclusions from the analysis were formulated based on qualitative studies and analyses of source materials prepared by the EU, as well as research and financial institutions (surveys, reports, recommendations), and on the basis of available data.
Implementation of KLEMS Economic Productivity Accounts in Poland
Authors: Kotlewski Dariusz Cezary , Błażej Mirosław
Published: March 2018

The aim of the article is to demonstrate how the KLEMS economic productivity accounts for Poland have been performed. The main research problem was to find solutions to certain country‑specific data insufficiencies. On this basis, a hypothesis was put forward that by using some innovative but acceptable missing data assessment techniques, it is possible to supply sufficient data for Poland for the mentioned accounts. After an overview of KLEMS economic productivity accounts and the relevant fundamental methodology, the article presents further how specific data problems that have arisen have been solved.