bluuebunny/crossref_metadata_2025 huggingface dataset:
Violência escolar e racionalidade comunicativa
Authors: Moura Adrielly Benigno de , Santos Júnior Francisco Ribeiro dos , Brennand Edna Gusmão de Góes
Published: December 2022

Compreender a violência na sociedade contemporânea requer o mapeamento dos fatores geradores de atos violentos bem como sua prevenção por meio de políticas públicas e de processos educacionais. Este artigo traz algumas reflexões sobre a racionalidade comunicativa e a violência escolar no contexto da crescente exclusão social e a crise de horizontes utópicos para a construção da educação e da formação de sujeitos de direitos. A abordagem metodológica está ancorada na perspectiva da análise de conteúdo de Laurence Bardin (2016), do documento ‘Violência escolar e bullying: relatório sobre a situação mundial’, publicado pela Organização das Nações Unidas para a Educação, a Ciência e a Cultura (UNESCO). São analisadas as pretensões de validade das informações e dos dados considerados relevantes por meio da elaboração de dois eixos principais para analisar a violência escolar apresentada no relatório: a) definições e amparos legais; b) impactos e principais desafios sobre a violência escolar e o bullying. Nessa perspectiva, recorreremos à Racionalidade Comunicativa, ponto central da Teoria do Agir Comunicativo, de Jürgen Habermas, para refletir sobre os achados e saber quais as bases consideradas relevantes para se construir uma educação para a paz alicerçada no diálogo e no entendimento.
teoria habermasiana em um movimento formativo realizado durante a pandemia de covid-19
Authors: Fernandes Letícia Soares , Prederigo Allana Ladislau , Almeida Mariangela Lima de
Published: December 2022

Considerando a importância dos processos de formação continuada de profissionais da educação, objetiva-se analisar um movimento formativo de Gestores de Educação Especial no ano de 2020, durante a pandemia de Covid-19, por meio das funções mediadoras da relação teoria e prática, sustentada no referencial teórico de Habermas e os autores Carr e Kemmis. Realiza-se uma análise documental de cunho qualitativo do Grupo de Estudo-Reflexão: Gestão de Educação Especial enquanto processo formativo. Os grupos de estudo-reflexão estão alicerçados na pesquisa-ação e se constituem como grupos autorreflexivos. Identifica-se a realização das funções por meio das ações formativas organizadas e implementadas em um movimento cíclico durante o período analisado, além disso, os dados apontam ganhos positivos quando se trata do desenvolvimento autorreflexivo e a emancipação dos sujeitos envolvidos foram vivenciadas as funções mediadoras da relação teoria e prática. A identificação das funções mediadoras se constitui como importante meio de averiguação das condições que tornam possíveis a geração de conhecimentos que sejam valorosos para as redes de ensino. Defende-se a necessidade de discutir, pensar e investir em formações críticas como forma de romper paradigmas instituídos no bojo de uma racionalidade instrumental.
QSAR of SARS-CoV-2 Main Protease Inhibitors Utilizing Theoretical Molecular
Descriptors
Authors: Nandi Sisir , Kumar Mohit , Saxena Anil Kumar
Published: December 2022

Background:

COVID-19 is caused by a novel strain of severe acute respiratory syndrome
coronaviruses (SARS-CoV-2). It has claimed casualties around the world since the end of 2019 due to its
high virulence and quick multiplicity in the human body. Hence, there has been a requirement to develop
effective remedial measures to mitigate the mortality. Scientists have been able to develop corona
vaccines to provide immunity, but there are no specific small-molecule chemotherapeutics to combat the
novel coronavirus which has spread to the whole world due to its contagiousness. In the viral genome
exploration, it has been found that the main protease, also known as chymotrypsin-like cysteine protease
([Mpro] or 3C-like protease [3CLpro]) is responsible for the novel coronavirus replication, transcription,
and host immunity destruction.

Objectives:

Therefore, the main protease has been selected as one of the major targets for the design of
new inhibitors. The protein crystallographic and molecular docking studies on SARS-CoV-2 Mpro inhibitors and some quantitative structure-activity relationship (QSAR) studies have been carried out on SARSCoV main protease inhibitors to get some lead molecules for SARS-CoV-2 inhibition. However, there is
hardly any QSAR done on the diverse data of SARS-CoV-2 main protease inhibitors. In view of it, QSAR
studies have been attempted on SARS-CoV-2 Mpro inhibitors utilizing theoretical molecular descriptors
solely computed from the structures of novel corona viral main protease inhibitors.

Methods:

Methods: As the number of structural descriptors is more than the observations, a genetic algorithm coupled with multiple linear methods has been applied for the development of QSAR models taking diverse
SARS-CoV-2 Mpro inhibitors.

Results:

The developed best QSAR model showing R2
, Q2
Loo, and R2
pred values of 0.7389, 0.6666, and
0.6453 respectively has been further validated on an external data set where a good correlation (r = 0.787)
has been found.

Conclusion:

Therefore, this model may be useful for the design of new SARS-CoV-2 main protease inhibitors.
Internet of Medical Things – The Future of Healthcare
Authors: Wal Pranay , Wal Ankita , Verma Neha , Karunakakaran Rohini , Kapoor Anupriya
Published: December 2022

Background:

The Internet of Medical Things (IoMT) is now being connected to medical equipment to make patients more comfortable, offer better and more affordable health care options, and make it easier for people to get good care in the comfort of their own homes.

Objective:

The primary purpose of this study is to highlight the architecture and use of IoMT (Internet of Medical Things) technology in the healthcare system.

Methods:

Several sources were used to acquire the material, including review articles published in various journals that had keywords such as, Internet of Medical Things, Wireless Fidelity, Remote Healthcare Monitoring (RHM), Point-of-care testing (POCT), and Sensors.

Results:

IoMT has succeeded in lowering both the cost of digital healthcare systems and the amount of energy they use. Sensors are used to measure a wide range of things, from physiological to emotional responses. They can be used to predict illness before it happens.

Conclusion:

The term “Internet of Medical Things” refers to the broad adoption of healthcare solutions that may be provided in the home. Making such systems intelligent and efficient for timely prediction of important illnesses has the potential to save millions of lives while decreasing the burden on conventional healthcare institutions, such as hospitals. patients and physicians may now access real-time data due to advancements in IoM.
Alternative Building Materials – Road to Sustainability
Authors: Jeeva Chithambaram S. , Bishnoi Pardeep , Singh Abhijeet , Rampradheep G.S. , Ravichandran C.
Published: December 2022

The fundamental and most essential components in building construction are materials. Good design along with the properties of materials (chemical, physical and mechanical) are accountable for a building’s material strength. The concept of sustainability in building materials revolves around the development and use of ecofriendly materials that have the same or enhanced properties as compared to that of conventional building materials. However, in the recent past, the use of conventional building materials in building construction has resulted in environmental degradation. Sustainability can be achieved by using industrial waste materials (by-products) and/or recycling and reusing the materials in building construction. Cost (manufacturing and transportation) has been a predominant factor considered while comparing related materials for the same purpose. This chapter discusses the need for alternative sustainable building materials with regard to energy and environmental impact caused by traditional or conventional building materials. Also, this chapter discusses sustainable initiatives carried out by researchers to discover low technology construction techniques. Further, this chapter discusses how alternative building materials can lessen the impact of environmental degradation, resulting in a healthier, cost-effective, and sustainably safe living environment.
Smart Waste Management to Enrich Cleanliness and Reduce Pollution in the Environment
Authors: Shenbagavadivu N. , Bhuvaneswari M. , Jenilasree G.
Published: December 2022

The forecast of waste generation is an essential step for adequate waste
management planning since it involves various factors that can affect waste trends. Due
to over-population in urban areas, the rate of garbage production has been increasing
rapidly. To simplify the process, a proposed solution for a smart solid waste
management system has been implemented. The proposed smart bin has a faster and
more intelligent separation process of the waste material.
Industrial Biofilter Design for Removal of Hydrogen Sulphide (H2S) from Wastewater Treatment Plants
Authors: Shareefdeen Zarook
Published: December 2022

Hydrogen sulphide (H2S) is the main odor-causing, toxic, and corrosive
chemical found in wastewater treatment operations. Bio-oxidation based processes for
air pollutant removal have become more attractive to the industry and numerous
wastewater treatment facilities have replaced conventional air treatment technologies
such as adsorption and chemical scrubbing with bio-oxidation based processes such as
biofilters. Of the three main types of air phase bioreactors, biofilter is used more
commonly than the others due to its simple configuration, ease of operation, and
economic benefits. This chapter addresses challenges in the industrial biofilter design
for H2S removal from wastewater treatment facilities. Wastewater industry
professionals, biofilter customers, biofilter vendors, and researchers who work in the
field of odor and H2S emission control and biofilter design will find this chapter very
useful.
A New Method of Multistage Optimal Homotopy Asymptotic Method for Solution of Fractional Optimal Control Problem
Authors: Okundalaye Oluwaseun O. , Özdemir Necati , Othman Wan A. M.
Published: December 2022

This paper deals with a recent approximate analytical approach of the
multistage optimal homotopy asymptotic method (MOHAM) for fractional optimal
control problems (FOCPs). In this paper, FOCPs are developed in terms of a
conformable derivative operator (CDO) sense. It is validated that the right CDO
appears naturally in the formulation even when the system dynamics are described
with the left CDO only. The CDO is employed to enlarge the stability region of the
dynamical systems of the optimal control problems (OCPs). The necessary and
transversal conditions are achieved using a Hamiltonian technique. The results
demonstrated that as the fractional-order solution derivative tends to integer-order 1,
the formulations lead to integer-order system solutions. Numerical results and a
comparison with the exact solution and other approximate analytical solutions in
fractional order are given to validate the efficiency of the MOHAM. Some numerical
examples are included to demonstrate the effectiveness and applicability of the new
technique.
Fortalecimiento de la industria 4.0 en MiPymes: una vía para el desarrollo local
Authors:   Universidad Sergio Arboleda, Payares Ayola Marceliano Simón , Zapata Morán María Gabriela ,   Universidad Sergio Arboleda
Published: December 2022

Los beneficios que las micro, pequeñas y medianas empresas otorgan al desarrollo local resulta ser una pieza clave para el crecimiento económico. Con el paso del tiempo y con la evolución que las nuevas tecnologías continúan trayendo consigo, han surgido nuevas necesidades para mantenernos actualizados ante las crecientes exigencias. De esta manera, resulta fundamental analizar el desarrollo que deben adquirir las nuevas capacidades y conocer los procesos a los que las MiPymes se deben adaptar para conseguir un crecimiento local. Asimismo, es igual de importante conocer el contexto bajo el cual estas empresas se desenvuelven para conocer de primera mano las facilidades con las que cuentan o, por el contrario, las dificultades a las que se deben enfrentar, el objetivo del presente artículo es abordar desde la madurez digital de las empresas en una revisión de literatura y técnica de metodología cuantitativa. Se encontró que en las MiPymes del Magdalena hay un bajo nivel de digitalización lo que incide en el desarrollo local del departamento.
Influência dos anéis de crescimento nas propriedades mecânicas da madeira de Pinus
Authors: Mayard Raynord , Segundinho Pedro Gutemberg de Alcântara , Santos Lorenzo Lube dos , Gonçalves Fabricio Gomes , Silva João Gabriel Missia da
Published: December 2022

A inspeção visual é o primeiro parâmetro de qualidade de dois materiais, principalmente, no que se refere à madeira, que apresenta defeitos naturais, a um exemplo de madeira de Pinus . O objetivo deste estudo é avaliar a relação entre dois anes de crescimento e as características físico-mecânicas da madeira de Pinus taeda e Pinus elliottii . Foram utilizados 1.600 corpos de prova de madeira ,com dimensões, aproximadamente, de 89 × 39 × 90 [mm³]. Os corpos da prova foram fixados para melhor visualização de dois anis de crescimento e quantificados por polegada. A densidade aparente foi endossada de acordo com instrumento normativo. Para a determinação da proporção da área e espessura do lenho tardio, temos uma análise do crescimento, das faces de dois corpos do foram prova escaneados, e a proporção da área do lenho tardio / inicial quantificada por meio de um software analisador . Os corpos da prova foram separados pelo número do ânus de crescimento e sua forma de aparência no plano não transverso, totalizando cinco tratamentos. Em seguida, foram realizados testes de resistência à compressão normal às fibras por meio de quatro métodos diferentes (ABNT - F c, 90 , ISO - F c, 90, ASTM-F c, 90 , ABNT-E c, 90 ). Como resultado, uma diferença significativa foi encontrada entre a média de dois cinco tratamentos usados ​​para resistência à compressão normal às fibras. Embora sejam necessários mais pesquisas com maior amplitude e corpos de prova com maiores dimensões, madeiras com anis de crescimento denso se mostraram mais resistentes.
АНДРОГЕННИЙ СТАТУС, ВМІСТ ВІТАМІНУ D В КРОВІ ТА СТАН ЕРЕКТИЛЬНОЇ ФУНКЦІЇ У ЧОЛОВІКІВ, ХВОРИХ НА ЦУКРОВИЙ ДІАБЕТ
Authors: Бондаренко Володимир , Хижняк Оксана , Саніна Євгенія , Скорняков Євгеній , Мінухін Андрій , Ніколаєв Роман , Червенко Олена
Published: December 2022

Існують дані, що дефіцит вітаміну D (Vit D) може сприяти розвитку андрогенодефіциту та еректильної дисфункції (ЕД) у чоловіків, у тому числі й хворих на цукровий діабет (ЦД). Мета дослідження. Встановити особливості змін еректильної функції та андрогенного статусу в залежності від вмісту вітаміну D в крові у чоловіків з цукровим діабетом 1 та 2 типів.
Матеріали та методи. Обстежено 65 чоловіків, хворих на ЦД віком 23-63 роки. У 28 пацієнтів був встановлений ЦД 1 типу (ЦД1) та у 37 чоловіків ЦД 2 типу (ЦД2). Аналізували індекс маси тіла (ІМТ), рівні тестостерону (Т), естрадіолу (Е2), їх співвідношення (Т/Е2), вміст Vit D в крові. Визначали стан еректильної функції (ЕФ) за допомогою Міжнародного Індексу Еректильної Функції (МІЕФ-5).
Результати. Аналіз рівнів Vit D в крові встановив, що їх середні значення у хворих на ЦД1 та ЦД2 суттєво не відрізняються між собою. При цьому середні величини вмісту Т в крові та Т/Е2 у чоловіків з ЦД1 були вірогідно більші. Показано, що формування D-гіповітамінозу у хворих на ЦД2 асоційоване зі зростанням ІМТ та частоти ожиріння, чого не відмічається за ЦД1. Не виявлено кореляційної залежності між рівнями Vit D та Т в крові в обох групах хворих, однак існує позитивна кореляція між вмістом Vit D в крові та величинами співвідношення Т/Е2 у хворих на ЦД2. У пацієнтів обох груп відсутня кореляція між рівнем Vit D та величинами МІЕФ-5. Між тим встановлена позитивна кореляція між величинами андрогенізації (рівень Т, величини Т/Е2) та величинами МІЕФ-5 у хворих на ЦД2.
Висновки. У чоловіків, хворих на цукровий діабет, незалежно від його типу, існує зниження вмісту в крові вітаміну D. У пацієнтів з цукровим діабетом 2 типу D-гіповітаміноз асоційований зі зростанням індексу маси тіла та частоти ожиріння. Ці фактори є передумовою у даного контингенту хворих як абсолютної, так і відносної гіпоандрогенемії. D-гіповітаміноз не призводить до формуванню андрогенодефіцита у чоловіків, хворих на цукровий діабет 1 типу. Предиктором розвитку еректильної дисфункції у хворих на цукровий діабет 2 типу є зниження рівня тестостерону в крові на тлі D-гіповітамінозу.
"Why must fireflies die so young?" The Picturesque of Caution in the Works of Studio Ghibli
Authors: Roy Samragngi
Published: December 2022

As opposed to most contemporary usage of the word “picturesque” – which is generally taken to mean visually attractive in a quaint or charming way, or else something that resembles a picture –  William Gilpin introduced this term to the English cultural debate in 1792. Gilpin used “picturesque” to typify an aesthetic ideal wherein roughness, raggedness, and ruins would be privileged over smoothness, symmetry and perfection. Over time, his conceptualization of “the picturesque” led to a celebration of disorder, decay, and ruin, a kind of glorification of violence also familiar to the Gothic romances of the late eighteenth and early nineteenth centuries. However, following the unimaginable havoc and mass destruction caused by the two world wars, ruins and images of ruins started to be viewed very differently. This paper seeks to explore how the picturesque mode has been used as an instrument of caution in the works of Studio Ghibli, spearheaded by two creative artists and directors, Hayao Miyazaki and Takahata Isao, who have experienced the horrors of WWII firsthand in their own childhoods. This paper specifically looks at two famous anime feature films produced by Studio Ghibli – Grave of the Fireflies (1988) and Howl's Moving Castle (2004) – that deal with the impacts of war and convey strong anti-war messages by uniquely employing the picturesque mode of representation.
Anime Convention Attendance in Response to Covid-19
Authors: Alberto Maria , Tringali Billy
Published: December 2022

The following report is meant to be paired with the dataset collected through the “Anime Conventions and COVID-19” survey. Designed by Maria K. Alberto and Billy Tringali,  this survey collected participants’ thoughts about their involvement in and perception of anime conventions before, during, and after the Covid-19 pandemic lockdowns. Both the dataset and associated survey questions can be found in the supplemental files paired with this report, or downloaded through the Hive, the University of Utah’s Research Data Repository. See: “Dataset for: Survey of Anime Convention Attendance in Response to Covid-19” at https://hive.utah.edu/concern/datasets/qj72p722r
Serological detection of Cytomegalovirus in blood samples from infected women in Misan province, Iraq
Authors: H. Alrashedi Hasan S. , Hassoon Hind J.
Published: December 2022

Cytomegalovirus is a species of Herpesviridae can that infect humans and cause latent and severe infections. Severe human infection caused by Human Cytomegalovirus (HCMV) usually occurs in humans who suffer from immunodeficiency. This research aims to detect antibodies IgM as a primary infection and IgG as a secondary infection in women suffering from repeated abortion and determines the more ages susceptible to HCMV infection. Blood sera were taken from females of different ages, from 15-45 years, based on clinical manifestation and abortion. The sample sizes in this study were taken from 150 patients, of which 100 cases were positive for HCMV. We recorded a high percentage of CMV infection (25%) and a high abortion rate (27.5%) in patients at age 20-24 years with a high rate of IgG, and we noticed a low rate of CMV infection (10%) in the age group 35-39 years with a low rate of IgG, we also reported a high abortion rate (27.27%) related with present IgM. The percentage of abortion was (26.66%) reported in patients ages 15-19 and 40-45 years, with (a 33.33%) rate of IgM and IgG.

Keywords: Human Cytomegalovirus HCMV; abortion; IgM; IgG.
Якість життя як мотиваційний показник ефективності реабілітаційного процесу. Оригінальний опитувальник якості життя пацієнта відділення нейрореабілітації
Authors: Sidelkovskiy O. , Rybalka O. , Savchuk M.
Published: December 2022

У реабілітології, особливо в неврологічній практиці, якості життя хворого завжди надається велике значення. Якість життя — один із головних показників, що характеризує духовний, емоційний, економічний стан людини, у центрі якого завжди знаходиться здоров’я індивідуума. Якщо один з її маркерів не відповідає очікуванням, людина може не тільки втратити емоційну забарвленість і зовнішню привабливість якості життя, але й мати значно серйозніші наслідки — втрату сенсу життя. На наш погляд, аналіз якості життя пацієнта й визначення ставлення хворого до порушених функцій організму й запропонованого курсу лікування (комплаєнс) є альфою та омегою всієї реабілітаційної допомоги. Наведений варіант оригінального орієнтовного опитувальника якості життя пацієнта дає можливість фахівцю (особливо в неврологічній практиці) скласти базове уявлення про його основні постулати. Якщо на один з пунктів опитувальника відповідь «так», у висновку зазначається: якість життя порушена. Коли в процесі проведення опитування виявляється критичне ставлення хворого до запропонованого лікування, цілі й задачі реабілітації можуть бути докорінно переглянуті.
Osteoarthritis and intestinal microbiota: pathogenetic significance of the joint — gut — microbiome axis
Authors: Golovach I.Yu. , Rekalov D.G.
Published: December 2022

Introduction. Osteoarthritis (ОА) is a disease leading to joint degeneration, accompanied by constant pain, inflammation, and functional failure of the joints. Although many factors contribute to the development of ОА, the gut microbiome has recently emerged as an important pathogenic factor in ОА initiation and progression. The purpose of the study was to analyze modern literature data regarding the link between the gut microbiome and ОА. Materials and methods. The available data of clinical studies and scientific reviews were analyzed, and modern meta-analyses on the influence of gut microbiota on the development and progression of ОА were evaluated. Results. Gut microbiota is responsible for a number of metabolic, immunological, and structural and neurological functions, potentially elucidating the heterogeneity of OA phenotypes and formation of individual features of the course of the disease. Numerous studies support the hypothesis of the existence of a gut – joint axis and the interaction between gut microbiota and OA-relevant risk factors. The proposed concept begins with intestinal disruption and dysbacteriosis, disruption of microbiota homeostasis, continuous changes in microbial composition and genomic plasticity for optimal adaptation of bacteria to the host environment, accompanied by both adaptive and innate immune responses due to translocation of bacteria and bacterial products into the bloodstream to the joint. This cascade ultimately leads to inflammation in the joint and contributes to the development and progression of OA. Interpretion of the potential mechanisms of OA pathogenesis is essential for the development of new preventive and disease-modifying therapeutic interventions. In addition, gut microbiota is also a potential biomarker related to inflammation and gut dysbiosis to predict the progression of ОА and monitor the effectiveness of therapeutic interventions. Conclusions. In this review, we summarized research data that are supporting the hypothesis of a “joint – gut – microbiota axis” and the interaction between gut microbiota and the OA-relevant factors, including age, gender, metabolism, obesity.
Arterial stiffness, vascular calcification and osteoporosis — common mechanisms of interaction (literature review)
Authors: Nishkumay O.I. , Mostbauer H.V. , Alekseenko O.O. , Moskalenko K.I. , Lazarev P.O. , Shevchuk M.I.
Published: December 2022

Introduction. The problem of cardiovascular morbidity and mortality remains an urgent issue of modern medicine, and arterial stiffness is its independent predictor. Lively discussions about the correct approach to the prevention and treatment of comorbid conditions – increased vascular stiffness as an influential factor of the cardiovascular events and decreased bone mineral density (osteoporosis), primarily arise against the background of the need and safety of calcium and vitamin D supplements. The purpose was to search for literature data as for possible common pathogenetic links in the progression of arterial stiffness and the development of osteoporosis in order to assess the safety of the use of drugs to prevent osteoporotic fractures. Results. Analysis of literature sourses had showed that possible osteogenic factors affecting arterial stiffness may be: secondary hyperparathyroidism, disbalance of the RANK/RANKL/OPG system, inhibition of vitamin K-dependent matrix proteins (Gla-protein), osteopontin, etc. Conclusions. Today, there are many hypotheses confirming the possible influence of osteogenic factors on vascular stiffness and arterial calcification. Therefore, the search for sensitive markers and the development of screening protocols for the patients with risk factors for both osteoporosis and vascular changes are extremely relevant. A special issue is the possibility of using monotherapy for these comorbid pathologies, which can safely and efficiently influence the prevention of complications – both low-energy osteoporotic fractures and cardiovascular catastrophes. This will be the focus of our further research.
Marketing strategy: The Influence of Corporate Social Responsibility on Brand Awareness
Authors: Ismael Zain Noori
Published: December 2022

The concept of corporate social responsibility (CSR) has gained extensive consideration in recent years. Nowadays firms are using CSR to gain competitive advantage and to establish long lasting relations with its stakeholders. Although CSR is much popular in the developed world but the potential benefits of CSR are less highlighted in the developing markets like Kurdistan. A quantitative approach was applied for data analysis in this study. Researcher employed a random sampling technique to obtain data from participants so that their study would be representative of the entire population of interest. The researchers gathered data from a wide range of shops in the Sulaimaniah area. Only 268 of the city of Sulaimaniah's 300 questionnaires were returned with all the required fields filled out. The findings of this research aim to shed light on the correlation between CSR and brand awareness. In the study, brand awareness was measured by looking at the environment, the community, and the workplace, which are all dimensions of corporate social responsibility.
Regionalizando la larga Guerra Fría en México
Authors: Kloppe-Santamaría Gema
Published: December 2022

Este artículo tiene como objetivo analizar el impacto que el ámbito regional tuvo en la manera en la que las personas vivieron los discursos, las prácticas y los conflictos que caracterizaron el periodo de la larga Guerra Fría en México. El artículo se centra en la historia regional de Puebla, un estado marcado por la prevalencia de ideologías anticomunistas y conservadoras, así como por una relación estrecha entre la iglesia católica, la élite económica y los grupos políticos dominantes. Con base en literatura secundaria y el análisis de fuentes archivísticas y publicaciones periódicas correspondientes al periodo de 1930 a 1979, el artículo busca ir más allá de una visión que subsume la historia de la Guerra Fría en el país dentro del juego de fuerzas protagonizado por las dos grandes potencias —Unión Soviética y Estados Unidos— y subrayar la importancia de lo local en las ideas y prácticas que definieron este periodo.
The Position of Islamic Education According to the National Educational System in Indonesia
Authors: Mansir Firman
Published: December 2022

Education is a part of the region that requires state participation to be properly optimized. Meanwhile, educational meetings with state power always end in the use of education in the name of the interests of power. Islamic Education as a subsystem of National Education in Indonesia is an important part that cannot be separated. The linkage between education and state power can be seen as well as the linkage between institutions in society and state organizers. Educational institutions in their form in the form of schools, madrasahs, and pesantren eventually intersect with state power. The implementation of Islamic education concerns education management so that system changes can undergo changes and determine the direction of Indonesia's education policy. This research uses qualitative methods. In collecting data through literature study studies, by collecting various literature spread from various journals and research books, which are then analyzed descriptively analytically. Thus, Islamic education has become the axis of state power in the field of education, it can even determine whether the country is progressing or not resting on the quality of Islamic education represented by madrasahs and Islamic boarding schools, and other Islamic educational institutions.
A Review on Herbal Cosmetics and Cosmeceuticals
Authors: Jain Sameeksha , Trivedi Mahima , Raikwar Manoj , Lodhi Maniram , Ali Meer Yousuf , Purohit Arpana , Nema Prakhar
Published: December 2022

Human beings have been using herbs for different purpose like food, medicine, beautifying. The word cosmetic was derived from the Greek word “kosm tikos” meaning having the power, arrange, skill in decorating. The natural herbs and their products when used for their aromatic value in cosmetic preparation are termed as herbal cosmetics. The increased demand for the natural product has created new avenues in cosmeceuticals market. The herbal Cosmetics have been the first choice of the customers, for being more potent, easily available and thought to be less side effective. Herbal cosmetics are Fastest growing field of personal care products. Cosmeceuticals is the fastest growing segment of the personal care products these are cosmetic preparations which contain biologically active principles or ingredients of plant origin. In recent years there is an increased demand for the use of herbs in cosmetics due to their mild action and less toxic in nature and they are found to be more effective. The desire of good looking and to be beautiful gave a huge market for the herbal cosmetics. Now a days desire to be look younger than original age, to be look beautiful, fresh, charming and fair have directly increased the demand of herbal cosmetics as well as of the Cosmeceuticals in the market. Hence the review overlooks on the use of herbal cosmetics and cosmeceuticals. It also describes about herbs as cosmetics. Numerous herbal plants are available naturally; they having different chemical constituents used in cosmetics preparations. This review is based on focusing on the cosmeceuticals intended to enhance the health and beauty of skin.
Keywords: Herbal cosmetics, cosmeceuticals, herbs, skin care, skin cosmetics, tooth cosmetics, hair cosmetics.
Immunostimulants: Concepts, Types and Functions
Authors: Jain Prince , Darji Pratik , Thakur Bhupendra Singh , Jain Anushree , Jain Prateek Kumar , Khare Basant
Published: December 2022

The proper functioning of human immune system is essential for organism survival against infectious, toxic and oncogenic agents. The concept of immunomodulation was proposed by Edward Jenner, while working on polio vaccine in 1796. A brawny, fine-functioning immune system is the keystone of excellent health. Immune replies are the consequence of an effectual interaction among innate (natural and non-specific) and acquired (adaptive and specific) components of the immune system. Inequity or failure of the immune systems is connected with a variety of chronic illness counting allergies, autoimmune diseases, cancers and furthers. Immunomodulators are natural or synthetic materials that regulate the immune system and induce innate and adaptive defense mechanisms. These substances are classified into two types, immunostimulants and immunosuppressants. Immunostimulants can enhance body's resistance against various infections through increasing the basal levels of immune response. These agents could increase the oxidative activity of neutrophils, augment engulfment activity of phagocytic cells and stimulate cytotoxic cells as necessary defense mechanisms. The researchers classified the immunostimulants using their origin and mode of action such as bacterial products, complex carbohydrates, vaccines (antigens and adjuvants), cytokines, immunoenhancing drugs, nutritional factors, animal extracts, and plant extracts. The link between immune system with diet, exercise, sleep, stress, microbial exposure, alcohol, water, hygiene are found to influence the immune response to a greater extent. Immunostimulants and some immunity enhancing nutrients improve the functioning of the immune system. In addition, some preventive measures such as healthy diet or proper nutrition, moderate exercise, sound sleep, drinking adequate water, subclinical exposure to microbes and managing stress, good hygiene, are altogether capable of boosting the immune system. In this review, the concepts, types and functions of immunostimulants will be described as a therapeutic approach against different diseases.
Keywords: Immunomodulators, Immunostimulants, Adjuvant, Mechanism, Immune system.
Contemporary Trends in Dental Implants
Authors: Jain Sanyam , Soni Sani , Lodhi Shivani , Khan Rubeena , Jain Anushree , Khare Basant , Thakur Bhupendra Singh , Jain Prateek Kumar
Published: December 2022

A high number of patients have one or more missing tooth and it is estimated that one in four world subjects over the age of 74 have lost all their natural teeth. Many options exist to replace missing teeth but dental implants have become one of the most used biomaterial to replace one (or more) missing tooth over the last decades. Therefore, the use of dental implants is also a common practice. Although research on dental implant de­signs, materials and techniques has increased in the past few years and is expected to expand in the future, there is still a lot of work involved in the use of better biomaterials, implant design, surface modification and functionalization of surfaces to improve the long-term outcomes of the treatment. This paper provides a brief history and evolution of dental implants. It also describes the types of implants that have been developed, and the parameters that are presently used in the design of dental implants. Finally, it describes the trends that are employed to improve dental implant surfaces, and current technologies used for the analysis and design of the implants.
Keywords:  Dental implants, History, Design, Surfaces, Osseointegration, Biopolymers.
Gluten free product tepung singkong sebagai alternatif pembuatan dessert box pandan
Authors: Anggareta Putu Cintia
Published: December 2022

Hidangan penutup telah menjadi menu yang sangat populer, semua orang bisa menikmati makananpenutup dimanapun dan kapanpun salah satunyagulten free product: tepung singkong sebagai alternatif pembuatan dessert box pandan. Tujuan dari penelitian ini adalah untuk memperkenalkan masyarakat khususnya para penderita penyakit celiac dengan memanfaatkan tepung singkong sebagai alternatifdalam pembuatan gluten free desert box pandan. Metode penelitian ini menggunakan teknik pengumpulan data berupa observasi, dokumentasi, dan kuesioner untuk mengetahui kualitas produk. Teknik analisis data yang digunakan adalah data kuantitatif, berbasis organoleptik dan uji pasar dengan menggunakan 25 panelis. Hasil penelitian ini merupakan hasil dari uji kuesioner yang di sebarkan kepada 20 masyarakat umum dan 5 kepada panelis yang ahli di bidang tata boga. Kesimpulan dari penelitian ini adalah gluten free product: tepung singkong sebagai alternatif pembuatan dessert boxpandan ini memiliki kualitas rasa, warna, tekstur, aroma yang baik. Dari hasil uji pasar presentase konsumen yang berminat membeli gluten free product:tepung singkong sebagai alternatif pembuatan dessert box pandan sangat baik yaitu 92% dan menyetujui jikaproduk ini menjadi trobosan baru di dunia bisnis kuliner yang menyehatkan. Dari hasil analisis biaya dalam pembuatan 1 kali resep pembuatan gluten free product: tepung singkong sebagai alternatif pembuatan dessert box pandan membutuhkan biaya sebesar Rp 39.500.
Kualitas selai berbahan dasar salak pondoh dengan sari bunga telang (clitoria ternatea)
Authors: Kristiani Ni Komang
Published: December 2022

Selai adalah salah satu jenis makanan awetan berupa sari buah-buahan yang sudah dihancurkan, ditambah gula dan dimasak hingga kental. Jenis salak yang di pakai pada penelitian ini adalah Salak Pondoh, karena jenis salak ini memiliki rasa yang manis dan tidak sepat sehingga cocok di jadikan selai. Pada penelitian kali ini penulis memanfaatkan sari bunga telang sebagai bahan pewarna alami. Tujuan penelitian ini untuk mengetahui kualitas selai berbahan dasar salak pondoh dengan sari bunga telang dari segi rasa, aroma, tekstur, warna, daya tahan dan biaya produksi. Metode yang digunakan adalah metode kuantitatif dan kualitatif. Metode kuantitatif dalam penelitian ini yaitu uji organoleptik yang diambil dari 30 responden dan analisis biaya produksi sedangkan metode kualitatif yaitu dengan uji daya tahan. Dari hasil penelitian ini menunjukan bahwa rasa dari selai tergolong enak dengan skor 123, tekstur dari selai tergolong cukup kental dengan skor 100, aroma tergolong harum dengan skor 111, dan warna tergolong terang dengan skor 112. Selai ini memiliki daya tahan sampai 5 hari dengan biaya produksi sebesar Rp. 14,076 per-jar.
Uji organoleptis perbedaan kualitas selai berbahan dasar selai lidah buaya (aloe vera) berdasarkan kandungan gula
Authors: Prakoso Eko
Published: December 2022

Selai adalah salah satu bahan makanan yang terbuat dari buah-buahan yang dihaluskan dan dimasak bersama gula hingga dan agak padat,Tujuan penelitian ini untuk mengetahui kualitas Selai Lidah Buaya berdasarkan berbagai kandungan gula dengan penelitian P0: 10%, P1: 20%, P3: 30% kandungan gula. Tempat penelitian di Denpasar,Waktu penelitian Bulan Januari- Juli 2021. Jenis penelitian adalah eksperimen dengan 3 perlakuan yaitu P0: selai berbahan dasar lidah buaya dengan 10% kandungan gula, P1: selai berbahan dasar lidah buaya dengan 20% kandungan gula, P2: selai berbahan dasar lidah buaya dengan 30% kandungan gula . dengan 15 kali ulangan untuk setiap perlakuan sehingga terdapat 45 buah sampel dengan menggunakan 15 orang panelis. Analisis data dari uji organoleptis yaitu warna, rasa, tekstur, aroma yang digunakan. Uji Kruskal Wallis dan dilanjutkan dengan uji antar perlakuan menggunakan Mann Whitney. Hasil penelitan menunjukan adanya perbedaan perbedaan yang nyata (p<0,05) warna dan rasa. antara P0, P1 dan P2. dan tidak ada perbedaan yang nyata p>0,05) tekstur dan aroma. Untuk mengetahui perbedaan antar perlakuan pada warna, ada perbedaan yang nyata (p<0,05) P0 dengan P1, warna tidak ada perbedaan yang nyata (p.>0,05) antara P0 dengan P2, tidak ada perbedaan yang nyata (p>0,05) antara P1 dengan P2, Pada Rasa, ada perbedaan yang nyata (p<0,05) P0 dengan P1, ada perbedaan yang nyata (p<0.05) P1 dengan P2, ada perbedaan yang nyata (p<0,05) P1 dengan P2.Selanjutnya pada pengujian aroma dan tekstur tidak ada peredaan nyata (P>0.5) P0, P1, P2.
Pengaruh motivasi dan pelatihan terhadap kinerja karyawan di the one legian hotel
Authors: Ali Furqhan Arief Suda Wiweka
Published: December 2022

Penelitian ini dilakukan oleh peneliti dengan tujuan untuk mengetahui Pengaruh Motivasi dan Pelatihan Terhadap Kinerja Karyawan. Penelitian ini dilakukan di The One Legian Hotel. Penelitian ini dimulai pada bulan Agustus 2020 sampai bulan November 2020. Metode pengumpulan data yang dilakukan dalam penelitian ini adalah dengan penyebaran kuesioner. Metode analisis data yang digunakan dalam penelitian ini adalah analisis regresi linier berganda yang kemudian digunakan untuk mengetahui pengaruh Motivasi (X1) dan Pelatihan (X2) terhadap Kinerja Karyawan (Y). Sampel pada penelitian ini berjumlah 98 orang karyawan dengan menggunakan kuesioner sebagai sebagai teknik pengumpulan data dan menggunakan teknik sampling Simple Random Sampling yaitu teknik pengambilan sampel dari anggota populasi yang dilakukan secara acak tanpa memperhatikan strata yang ada dalam populasi itu. Pengujian hipotesis pada penelitian ini dilakukan menggunakan SPSS versi 25 for Windows. Hasil penelitian ini menunjukkan bahwa, variabel Motivasi (X1) berpengaruh positif dan signifikan (0,000 < 0,05) terhadap Kinerja Karyawan dan variabel Pelatihan (X2) berpengaruh positif dan signfikan (0,019 < 0,05) terhadap Kinerja Karyawan (Y)
Entrevista com Marcos Natali: a literatura em questão
Authors: Natali Marcos , Martins Rodrigues de Moraes Anita
Published: December 2022

Entrevista
Aktivitas Seismisitas Di Wilayah Sumatera Bagian Utara Menggunakan Arc-GIS Periode 2020-2021
Authors: Anti Ayundita Arwi , Husna Lubis Lailatul , Wardono Wisnu
Published: December 2022

Pulau Sumatera merupakan daerah yang tinggi akan tingkat kegempaannya yang disebabkan karena berada pada daerah pertemuan antara dua lempeng yaitu Indo-Australia dibagian selatan dan lempeng Eurasia dibagian utara. Sumatera bagian Utara terletak pada koordinat 0o – 5o LU dan 96o – 101o BT. Tujuan dari penelitian ini untuk mengetahui aktivitas gempa bumi di wilayah Sumatera bagian Utara berdasarkan magnitudo dan kedalamannya pada tahun 2020 – 2021. Data yang digunakan berasal dari katalog gempa bumi BMKG Deli Serdang. Metode yang digunakan adalah metode kuantitatif dan deskriptif dan pemetaannya menggunakan aplikasi Arc-GIS 10.3. Hasil penelitian menunjukkan bahwa wilayah Sumatera bagian Utara pada tahun 2020 sampai 2021 memiliki tingkat kegempaan yang tinggi. Pada tahun 2020,gempa bumi yang terjadi sebanyak 1.352 kejadian dengan rentang magnitudo M1,2 hingga M4,9 dan rentang kedalaman 1 km hingga 750 km. Sedangkan pada tahun 2021, gempa bumi yang terjadi sebanyak 2.994 kejadian dengan rentang magnitudo M1,1 hingga M4,9 dan rentang kedalaman 1 km hingga 276 km.
Clinical value of ultrasound in diagnosis and classification of common arterial trunk
Authors: Su Xiao-rong , Li Tian-gang , Ma Bin , Wang Ai-lin , Wei Chuan-min , Tie Hong-xia , Guo Wenjing
Published: December 2022

Objectives: This study aims to explore the clinical value of
prenatal ultrasonography in the diagnosis of the common arterial trunk
(CAT) classification and associated deformities. Materials and
methods: The two-dimensional ultrasound images spatiotemporal image
correlations (STICs) and clinical data of 108 foetuses diagnosed with
CAT malformations were retrospectively analysed, their CAT types were
classified, and the correlations between these different types and
foetal malformations and pregnancy outcomes were analysed.
Results: Among the 108 foetuses, there were 47 cases (43.5%)
of type A1, 51 cases (47.3%) of type A2, 9 cases (8.3%) of type A3 and
1 case of type A4 (0.9%), of which 22 cases (20.4%) were isolated CAT,
56 cases (51.8%) had complex intra-cardiac structural abnormalities, 30
cases (27.8%) had intra-cardiac or extra-cardiac structural
abnormalities, 17 cases had 1 other system abnormality, and 5 cases had
2 other system abnormalities. Four cases were combined with 3 other
system abnormalities, while 4 cases were combined with 4 other system
abnormalities, among which the facial and physical abnormalities had the
highest incidence (40.0%). The STIC images were completely displayed in
88 cases (81.5%). Isolated CAT and CAT combined with other
malformations were significantly correlated with foetal pregnancy
outcomes ( P < 0.05). Conclusions: Prenatal
ultrasonography had a high clinical application value for classifying
CAT. Pregnancy outcomes were highly correlated with the classification
and combined intra-cardiac and extra-cardiac structural malformations.
The early assessment of foetal prognosis before birth has great value
for clinical intervention.
Physiologically-based pharmacokinetics modelling of Semaglutide in children and adolescents with healthy and obese body weights
Authors: Machado Thayná , Honorio Thiago , Domingos Thaisa , Paula Dailane Candido de , Cabral Lúcio , Rodrigues Carlos , Souza Alessandra , Abrahim-Vieira Bárbara
Published: December 2022

Aim: Develop PBPK models of semaglutide to estimate the pharmacokinetic
profile for subcutaneous (SC) injections in children and adolescents
with healthy and obese body weights. Methods: Pharmacokinetic modeling
and simulations of semaglutide SC injections were performed using the
Transdermal Compartmental Absorption & Transit (TCAT™) model
implemented in GastroPlus™ v.9.5 modules. A PBPK model of semaglutide
was developed and verified in the adult population, by comparing the
simulated plasma exposure with the observed data, and further scaled to
the pediatric populations with normal and obese body weight. Results:
The Semaglutide PBPK model was successfully developed in adults and
scaled to the pediatric population. Our P-PBPK simulations indicated a
significant increase in Cmax values for the 10-14 years pediatric
population with healthy body weights, which was higher than the observed
values in adults at the reference dose. Since gastrointestinal adverse
events are related to increased semaglutide exposure, peak
concentrations outside the target range may represent a safety risk for
this pediatric age group. Besides, PBPK models indicated that body
weight was inversely related to semaglutide exposure in children and
adolescents, which is in line with the results observed in population
pharmacokinetic studies in adults. Conclusion: Due to the absence of
semaglutide pharmacokinetic data for the pediatric population, these
PBPK models will aid in the development of dosing regimens and sampling
times. Thus, increasing the efficiency of future pediatric clinical
trial studies which can be replaced or improved by PBPK models.
Integrated multiomic study on the evolution and natural variation of flavonoid biosynthesis in Apocynum venetum and Apocynum hendersonii
Authors: Gao Gang , Abubakar Aminu Shehu , Chen Jikang , Chen P , Chen K , Yu Chunming , Wang Xiaofei , Qiu Xiaojun , Huang Xiaoyu , Shao Deyi , Wang Yue , Chen Yu , Zhu Aiguo
Published: December 2022

The genus Apocynum contains perennial bast fiber plants that are spread
worldwide. Apocynum species have great application prospect in
salt-alkali regions, are rich in flavonoids, and possess medicinal
significance. Here, we report the draft genomes of two species, Apocynum
venetum and Apocynum hendersonii, and elucidate their evolutionary
relationship. The high synteny and collinearity between A. venetum and
A. hendersonii suggested that the two species experienced the same WDG
event, indicating that divergence might be more recent. Comparative
analysis revealed that ApF3H and differentially evolved ApUFGT genes are
critical for determining natural variation in flavonoid biosynthesis
between relatives. ApF3H-1 enhanced the total flavonoid content and
promoted the antioxidant capacity of transformed plants compared to the
wild-type plant. ApUFGT5 and 6 explained the diversification of
flavonoids or their derivatives. These data provide biochemical insight
and knowledge on the genetic regulation of flavonoid biosynthesis,
supporting the adoption of these genes in breeding programs aimed at the
multipurpose use of plants.