bluuebunny/crossref_metadata_2025 huggingface dataset:
China's Legal Practices for Challenges of Artificial General Intelligence
Authors: Chen Bing , Chen Jiaying
Published: July 2024

The artificial general intelligence (AGI) industry, represented by ChatGPT, has impacted social order during its development, and also brought various risks and challenges such as ethical con-cerns in science and technology, attribution of liability, intellectual property monopolies, data se-curity, and algorithm manipulation. The development of AI is currently facing a crisis of trust. Therefore, the governance of AGI industry must be prioritized and the opportunity of the imple-mentation of the Interim Administrative Measures for Generative Artificial Intelligence Services should be taken. It is necessary to enhance the norms for the supervision and management of scien-tific and technological ethics within the framework of the rule of law. Additionally, it is also es-sential to continuously improve the regulatory system for liability, balance the dual values of fair competition and innovation encouragement, and strengthen data security protection systems in the field of AI. All of these will enable coordinated governance across multiple domains, stakeholders, systems, and tools.
FEATURES OF PHILOSOPHICAL METHODS IN THE STUDY OF CULTURE, SOCIETY, AND MAN
Authors: Vladlenova Iliana
Published: July 2024

Philosophical methods, which differ in their universality and focus on the search for fundamental principles, have been studied, which allows to complement scientific methods in the search for root causes and general patterns. It has been proven that philosophy not only intersects with other sciences and fields of knowledge, but also creates new fields of research. The creation of new methods within the framework of philosophy itself is considered. Philosophical methods are justified as more free and flexible compared to scientific methods, which allows philosophers to explore the nuances and complexities of concepts and ideas. The development of the philosophy of language, which gave a powerful impetus to the formation of universal translator programs based on artificial intelligence, is analyzed.
PHILOSOPHICAL ANALYSIS OF THE TRADITIONAL IMAGE OF NATURE IN ANCIENT CHINESE PHILOSOPHY
Authors: Zhang Hongwei
Published: July 2024

The article is devoted to the modern analysis of approaches to the image of nature in Ancient Chinese philosophy. In the research, the author focuses attention on the image of nature as an important element for research in ecological and philosophical discourses. The concept of understanding the concept of Nature in ancient Chinese philosophy is revealed. Attention is drawn to the peculiarity of Ancient Chinese philosophy as one of the oldest philosophies in the world, the specifics of its thinking and understanding of nature are revealed, which influenced the development of human civilization in general. The main question of this study is the analysis of approaches to the transcription of the image of nature in ancient Chinese philosophy and its significance for modern human civilization. By reviewing and analyzing the relevant literature, the evolution of this phenomenon is revealed.
GAP ANALYSIS IN PUBLIC MANAGEMENT OF SAFE ENVIRONMENT DEVELOPMENT IN RURAL TERRITORIAL COMMUNITIES OF UKRAINE
Authors: Bulba Volodymyr , Orobei Victor
Published: July 2024

The article rethinks the classical approach to using the GAP analysis method, examines the possibilities of its application in public management of rural areas, and evaluates innovative approaches in accordance with strategic directions for the development of the social sphere. Recommendations for improving existing innovative approaches have been developed and proposed. It has been proven that for the preservation of rural areas in Ukraine during the Russian-Ukrainian war and in the post-war period, an important strategic priority of public management is the development of a safe environment in the rural community ("Safe Community" concept, police stations, electronic services, Zero Waste concept, protecting the environment).
THE FORMATION OF GENDER HISTORY AND ITS SUBJECT
Authors: Malikov Vasyl
Published: July 2024

Thе article aims to highlight the foundation of gender history as a discipline and to reveal the process of formation and transformations of the subject of gender history in the research of American, European and Ukrainian historians. From the beginning it was connected with the development of the movement for human rights, feminism, the struggle for gender equality and non-discrimination. The pluralism of approaches to the study of gender history and the definition of its subject is shown regarding to the diversity of approaches to the essence of history and gender, their interaction with sexuality, body, identity, race, ethnicity and nationality, colonialism, power relations, dominance and subordination, and the meaning of gender in history.
THE VOLUNTEER MOVEMENT IN UKRAINE AND GERMANY IN THE LATE 20TH AND EARLY 21ST CENTURIES: COMPARATIVE ANALYSIS
Authors: Motenko Yaroslav , Shyshkina Yevheniia
Published: July 2024

The full-scale invasion of Russian troops into Ukraine in 2022 and the temporary occupation of a part of its territory made the issue of developing means of overcoming large-scale humanitarian disasters and ensuring the stability and security of the population of the European continent relevant for the world public. The authors of the proposed study consider the volunteer movement as a powerful tool of self-organization of society, capable of strengthening state structures in order to overcome crisis phenomena in the areas of ensuring the country’s defence capability, health protection of its population, and providing humanitarian aid to migrants.
Osmanlı’da Asayişi Sağlamaya Yönelik Bir Uygulama: Rumeli Çeteler Layihasının Tatbikine Dair Bir İnceleme [1909-1910]
Authors: Dağ Mustafa
Published: July 2024

Rumeli’de özellikle 20. yüzyılın başlarında çetecilik faaliyetlerinde artış yaşanmıştır. Bölgedeki çetecilik faaliyetleri etnik ve mezhepsel farklılık ile sosyo-ekonomik gerekçelerden dolayı zuhur etmiştir. Bu nedenle Osmanlı yönetimi çetecilikle mücadele çerçevesinde birçok nizamnameyi uygulamaya koymak zorunda kalmıştır. Bunlardan biri Rumeli Vilayetinde Şekâvet ve Müfsidatın Men’i ve Mütecassırların Takip Te’dibi Hakkında Kanun Layihasıdır. 1909 ile 1910 yılları arasında yürürlükte olan nizamnamenin tatbiki çalışmanın ana temasını oluşturmaktadır. Bu kapsamda elde edilen verilerin incelenmesiyle nizamnamede yer alan hükümlerin hangi bölgelerde ne şekilde tatbik edildiğini tespit etmek çalışmamızın temel amacını oluşturmaktadır. 1909 ile 1910 yılları arasında Rumeli vilayetleriyle İzmir ve Aydın bölgelerinde tatbik edilen nizamnamenin hükümlerine dair örnekler arşiv belgeleri ve telif eserlerden istifade edilerek incelenmiştir. Bu çerçevede nizamnamenin tatbik edildiği bölgeler ile oluşan tepkiler, İstitlâ’ Komisyonlarının yetki ve faaliyetleri, çetelerle mücadelede aktif olan görevliler ve Divan-ı Harp Mahkemeleri ile çetecilere verilen cezalar ayrı başlıklar halinde ele alınmıştır. Bu doğrultuda yürütülen çalışmayla layihanın hazırlanma sürecinin nasıl gerçekleştiği, layihada yer alan hükümlerin neler olduğu, layihanın Rumeli’de hangi vilayetlerde uygulanıp, uygulanmadığı, layihanın Anadolu’da hangi bölgelerde tatbik edildiği, tatbik sırasında karşılaşılan zorlukların neler olduğu, yakalanan çetecilere verilen cezaların neler olduğu ve son olarak layihada yer alan hükümlerin tatbiki karşısında ahalinin göstermiş olduğu tepkilerin neler olduğu tespit edilmeye çalışılmıştır.
Effect of Different Genetic Backgrounds on Rumen Microbiota and Serum Metabolic Phenotypes in Beef Cattle
Authors: Zhao Yaxing , Zhao Pengfei , Wu Yi , Li Xiaorui , Huangfu Mingke , Chen Zhimeng , Wang Chunjie , Liu Bo , Simujide Huasai , Chen Hao , Chen Aorigele , Zhang Chunhua , Sun Haizhou
Published: July 2024

Species with different genetic backgrounds exhibit distinct metabolic traits. Nine beef cattle were selected for the experiment to study changes in serum metabolic phenotypes, rumen microbiota diversity, and composition in beef cattle from different genetic backgrounds. Three groups were Chinese Simmental (S group), Simmental×Chinese Holstein (SH group), and Simmental × Mongolian (SM group) cattle. We used ELISA to detect serum biochemical indicators. The Short-chain fatty acids (SCFAs) in the rumen were examined, and a significant difference was observed in the acetic acid content of the three experimental groups (p < 0.01). The propionic acid content in the rumen of the S group was significantly higher than that of the SH and SM groups (p < 0.05). The A/P ratios of both the S and SM groups were significantly higher than that of the SH group (p < 0.05). We analyzed rumen microbiota composition and diversity in each group of cattle using 16S rRNA sequencing and found that their composition was generally similar in the three groups of crossbred fattening cattle; however, the f_Bacteroidales_RF16_group and g_norank_f_Bacteroidales_RF16_group were significantly enriched in the SH group, whereas Treponema and Spirochaetia were significantly enriched in the SM group. Spirochaetia was significantly enriched in the SM group. Differences in rumen bacterial enrichment indicated that starch, protein, and cellulolytic abilities differed among the S, SH, and SM groups. The results of Spearman correlation analysis confirmed the correlation between rumen genera and serum biochemical indices. Overall, differences in rumen microflora play an important role in influencing the serum metabolic phenotype.
Modification of zirconia with hydroxyapatite for bioactive enhancement as dental implants
Authors: Xing Zhongyuan , Pang Yongxin , Li Quan Bing Eric , Zhang Jian Yong , Xu Donglai
Published: July 2024

Zirconia is one of the best materials for making the crown in dental implant due to its excellent acid and base resistances and appearance close to natural teeth. In addition, its extraordinary mechanical properties render zirconia to be a potential candidate as dental implant, if its biocompatibility can be improved to promote adhesion to natural tissues. This study is to enhance the bioactivity of zirconia with the aim to improve its adhesion to the gingival when it is used as the crown of the implanted tooth.
Hydroxyapatite is the major component of natural bone and has very high bioactivity and thus is selected as the modifier to improve the bioactivity of zirconia. A series of zirconia/hydroxyapatite composites with varied compositions were prepared under different conditions in order to find out the optimal composites for the target application. Various analytical technologies and mechanical tests are employed to characterise structure and properties of resultant composites. Experimental results show that the component ratio and sintering temperature have significant influence on the composite properties. Increase in hydroxyapatite component tends to enhance bioactivity but decline mechanical strength. Experiments found that the composite containing 10% of hydroxyapatite retains sufficient mechanical strength as crown material whilst possesses excellent bioactivity. Sintering results suggest that the optimal mechanical strength is obtained at 1400°C for 2 hours for the composite containing 10% of hydroxyapatite.
Facile and efficient stereospecific deamination of aziridines using task-specific silica immobilized organosilane-based nitrite ionic liquid
Authors: Valizadeh Hassan , Vesali Esmaeil
Published: July 2024

Various cis and trans-aziridine derivatives were deaminated via the reaction with task-specific silica immobilized organosilane-based nitrite ionic liquid. Corresponding cis or trans-alkenes were produced as a stereospecific products in good to excellent yields. The advantages of this method include the one-pot procedure, operational simplicity, solvent-free and very short reaction times. Simple handling of this nitrite anione sourse nanoparticles and thus lowering the risks and hazards of a chemical process can offer other important advantages.
The Comparison of Compression and Conversion Performance for Real-time Volumetric Video Streaming by Using Dynamic Point Cloud and Mesh Coding
Authors: Choi Yihyun , Ryu Eun-Seok
Published: July 2024

In volumetric video content, dynamic 3D objects containing frame information, akin to a video, are utilized to depict the movement of 3D objects. Due to their larger data size compared to static 3D objects, efficient compression techniques are imperative for dynamic 3D objects. Consequently, the moving picture experts group (MPEG) has undertaken research on video-based dynamic mesh coding (V-DMC) for compressing dynamic mesh, and video-based point cloud compression (V-PCC) for compressing dynamic point cloud. Moreover, mesh and point cloud serve as data structures representing 3D object in virtual reality, each with distinct advantages and disadvantages. Hence, advancements in volumetric video can be anticipated through the conversion of dynamic point cloud obtained from real world into dynamic meshes, which offer rendering advantages. Enabling real-time streaming of volumetric video using dynamic mesh necessitates not only the conversion between dynamic point cloud and dynamic mesh but also efficient compression techniques tailored for dynamic point cloud or dynamic mesh. This paper conducts experiments involving conversion and compression from dynamic point cloud to dynamic mesh using a poisson surface reconstruction (PSR) based converter and international compression standards for dynamic mesh and dynamic point cloud. Furthermore, subjective performance evaluations are conducted on the experimental results, comparing the dynamic meshes generated using V-DMC and V-PCC.
‘More than a pill’: A qualitative co-exploration of the things that matter in young women's stories of adherence to antiretroviral treatment in South Africa
Authors: Hendricks Lynn , Young Taryn , Julies Robin , Dollie Rizqah , Dollie Reshaan , Hannes Karin
Published: July 2024

Background: Young women living with perinatal infections of the Human Immunodeficiency Virus (YWLPHIV) in low- and middle-income countries are more likely to be challenged by social and health inequities, which can make adherence to life-long treatment difficult. We aimed to learn more about how YWLPHIV in Cape Town negotiated their adherence to antiretroviral treatment (ART) within their material environments.
Methods: We adopted a multisensory arts-based community participatory approach and used visual and digital mediums for data-collection and analytical purposes. We developed an Adherence Assemblage model to guide our study. The co-research team consisted of three academics, seven YWLPHIV (although they approved the study they could not be named as authors to protect their identities), one counsellor and two visual ethnographers.
Results: We co-creatively synthesised our findings into one research documentary and five co-creative artworks. We synthesised four storylines: ‘living with a (un)exposed HIV secret’, ‘multisensory experience of adherence’, ‘things that matter in adherence’, and ‘engaging spaces and places’. Things such as the pill itself were perceived as triggers for associated memories and evoked emotional responses, impacting the adherence behaviours of YWLPHIV. At times, non-adherence was used as an act of control, with young women claiming power by rejecting the pills. Besides the more obvious lines of argument on power dynamics, the findings suggest that materiality influences adherence too. However, it is seldom used as an analytical concept to investigate challenges related to ART.
Conclusions: In conclusion, understanding the material environment's role in adherence is crucial for developing more effective support systems for YWLPHIV. Further research that prioritises the specific needs of YWLPHIV emotional, cognitive, and psychosocial development, while paying attention to the material environment is needed.
IMmuneCite: an integrated workflow for analysis of immune enriched spatial proteomic data
Authors: Barbetta Arianna , Bangerth Sarah , Lee Jason T.C. , Rocque Brittany , Torres Evanthia T Roussos , Kohli Rohit , Akbari Omid , Emamaullee Juliet
Published: July 2024

Spatial proteomics enable detailed analysis of tissue at single cell resolution. However, creating reliable segmentation masks and assigning accurate cell phenotypes to discrete cellular phenotypes can be challenging. We introduce IMmuneCite, a computational framework for comprehensive image pre-processing and single-cell dataset creation, focused on defining complex immune landscapes when using spatial proteomics platforms. We demonstrate that IMmuneCite facilitates the identification of 32 discrete immune cell phenotypes using data from human liver samples while substantially reducing nonbiological cell clusters arising from co-localization of markers for different cell lineages. We established its versatility and ability to accommodate any antibody panel and different species by applying IMmuneCite to data from murine liver tissue. This approach enabled deep characterization of different functional states in each immune compartment, uncovering key features of the immune microenvironment in clinical liver transplantation and murine hepatocellular carcinoma. In conclusion, we demonstrated that IMmuneCite is a user-friendly, integrated computational platform that facilitates investigation of the immune microenvironment across species, while ensuring the creation of an immune focused, spatially resolved single-cell proteomic dataset to provide high fidelity, biologically relevant analyses.
Boron-Deficient Molecules Tailored Inorganic-rich Cathode/Electrolyte Interphaces for Stable Li||LiFe 0.2 Mn 0.8 PO 4 Battery
Authors: Fang Guihuang , Liu Ying , Pan Ying , Yang Hongwei , Wu Maoxiang
Published: July 2024

Tributyl borate (TBB) is among the widely used film-forming electrolyte additives in lithium-ion batteries (LIBs). It possesses the capability to produce an inorganic solid electrolyte interphase with abundant polar boron-containing compounds, functioning as a solid electrolyte interlayer (or cathode electrolyte interlayer), thus effectively isolating the electrode material from the electrolyte and averting parasitic reactions. Herein, the TBB could contribute to the formation of an inorganic solid electrolyte interphase rich in polar B-F and B-O bonds, thus enhancing the stability of the interface between the electrolyte and cathode materials. The findings demonstrate that the inclusion of 0.5 wt% TBB significantly enhances the stability of the electrode/electrolyte interface in Li‖LiMn0.8Fe0.2PO4 batteries. After 600 cycles, the specific capacity reaches 107.9 mAh g− 1 with a capacity retention of 86.45%. This indicates outstanding electrochemical performance and excellent cycling stability. Consequently, TBB exhibits potential as an electrolyte additive for future high-energy density lithium batteries.
Enhancing Wheat Resilience to Salinity: The Role of Penicillium chrysogenum as a Biological Agent for Improved Crop Performance
Authors: Dargiri Soheila Aghaei , Naeimi Shahram , Nekouei Mojtaba Khayam , Kadkhodaei Saeid
Published: July 2024

Background and Aims
Salinity significantly impairs wheat (Triticum aestivum L.) growth and yield, posing a major challenge to agriculture. This study investigates the effectiveness of the fungal endophyte Penicillium chrysogenum in mitigating the adverse effects of salinity on wheat growth.
Methods
In this study, the effect of fungal endophyte P. chrysogenum on the improvement of morphophysiological and biochemical traits of wheat plant under salt stress (0, 50, 100 and 150 mM NaCl) was factorially conducted in the form of a completely randomized design with three replications in vitro and greenhouse conditions.
Results
Treatment of wheat seeds with P. chrysogenum resulted in superior germination rates under 150 mM saline stress compare to untreated control. Notably, the endophyte treatment led to enhancements in shoot and root lengths, as well as total fresh and dry weights, with increases of 57.52%, 169.23%, 10.65%, and 76.20%, respectively. The endophytes presence was associated with increased levels of hydrogen peroxide, malondialdehyde, proline, and soluble carbohydrates by 29.34%, 36.17%, 36.13%, and 76.54%, respectively. Enhanced concentrations of phenolic compounds, flavonoids, anthocyanins, and overall antioxidant activity were observed in treated plants, alongside elevated activities of antioxidant enzymes (CAT, POD, PPO, APX). These adaptations contributed to improved stress tolerance and a reduction in reactive oxygen species (ROS).
Conclusion
The results highlight P. chrysogenum as an effective biological agent for enhancing wheat resilience to salinity, offering a promising strategy for improving crop performance in saline areas. Further studies are needed to understand the complex interactions and practical agricultural uses.
Model-based characterization of metabolism of the recombinant adeno-associated virus (rAAV) production via Human Embryonic Kidney (HEK293) cells
Authors: Karimvand Somaiyeh Khodadadi , Cuperlovic-Culf Miroslava , Kamen Amine A. , Bolic Miodrag
Published: July 2024

In this study, we present a kinetic-metabolic model describing adeno-associated virus (AAV) production via Hek293 cells, encompassing the main metabolic pathways, namely glycolysis, tricarboxylic acid cycle (TCA), pyruvate fates, the pentose phosphate pathway, anaplerotic reaction, amino acid metabolism, nucleotides synthesis, biomass synthesis and the metabolic pathways of protein synthesis of AAV (capsid and Rep proteins). For the modelling, Michaelis-Menten kinetic is assumed to define the metabolic model. A dataset from bioreactor cultures containing metabolite profiles of adeno-associated virus 6 (AAV6) production via triple transient transfection at low cell density culture, including concentration profiles of glutamine, glutamic acid, glucose, lactate, and ammonium, is utilized for fitting and computing the model parameters. The model resulting from the adjusted parameters well defines the experimental data. Subsequently, a Sobol-based global sensitivity analysis procedure is applied to determine the most sensitive parameters in the final model.
Keep It Secret, Keep It Safe: Teaching Quantum Key Distribution in High School
Authors: WEISSMAN Efraim Yehuda , MERZEL Avraham , KATZ Nadav , GALILI Igal
Published: July 2024

Quantum Key Distribution (QKD) is a cryptography protocol based on the fundamental principles of quantum physics (QP). Teaching this subject does not require extensive knowledge beyond these principles, making it suitable for inclusion in high school curricula. Despite its relevance, teaching QKD in high schools is yet understudied. In this study, we collected responses from 12th -grade students from various schools that adopted and applied the Discipline-Culture vision of the physics curriculum. We assessed their understanding through conceptual and quantitative problems and examined their attitudes regarding the motivation to study this subject. We analyzed the responses using content analysis, identifying the challenges and affordances of teaching QKD. The challenges faced by students have been categorized into three themes: difficulties with QP, difficulties with the QKD protocol, and difficulties with the mathematics involved in this context. This work enhances educators’ ability to address the challenges of teaching QP and suggests that teaching QKD in high school strengthens students’ motivation to study QP.
Identification of soil erosion‑susceptible areas using fuzzy logic and sediment transport index aided by mineralogical-granulometric analysis in Subansiri basin, Assam, India
Authors: Dutta Borneeta , Srivast Pankaj , Boruah Annapurna
Published: July 2024

Erosion poses a significant challenge along the river Subansiri in Assam, India impacting river banks and sediment breakdown. This paper presents a comprehensive study on the identification of soil erosion-susceptible areas in the Subansiri Basin using fuzzy logic modeling and sediment transport index (STI) analysis with emphasis on X-Ray Diffraction (XRD) and grain size analysis. The soil erosion map's overall findings showed that the areas it covered were vulnerable to erosion in severe, very high, high, moderate, and low levels. Slope gradients and flow accumulation were used to calculate the STI on the Raster Calculator in ArcGIS. The Sediment Transport Index ranges from 0 to 2770. This study also aims to elucidate the mineral composition and grain size distributions of sediments sourced from the Subansiri river in Assam. Examination of 12 soil samples facilitated the assessment of their mineral composition and size distribution. Sieve analysis unveiled that a predominant 80% of the soil along the Subansiri river constitutes sand, with lesser percentages attributed to silt and clay, following USDA primary classification guidelines. Utilizing XRD methodology, the major crystalline minerals identified in these sands encompassed Quartz, Montmorillonite, Illite, Calcite, and Plagioclase Feldspar Albite. Skewness and kurtosis is also studied to determine the shape and distribution of the soil samples and the values range from 0.25 to 0.70 signifying a fine skewed to very fine skewed and from − 1.16 to -1.93 showing a very platykurtic distribution. Thus, for a thorough investigation of soil erosion, this research provides a novel hybrid methodology that integrates fuzzy logic, STI, XRD and grain size analysis.
Radiographic Evaluation of Arthritis Conditions
Authors: Khattab Khalid , Altounian Hrag , Zahra Sufian
Published: July 2024

Objective: To provide a comprehensive analysis of arthritis, with the aim of identifying its underlying causes, developing effective strategies for early diagnosis, and providing treatment recommendations aimed at reducing the impact of these diseases on patients.
Methods and materials: Diagnostic methods used included magnetic resonance imaging (MRI), X-rays, and clinical examinations to determine the progress of diseases and their response to treatment.
Results: Signs Radiological signs seen on plain radiographs of cases of degenerative arthritis: narrowing of joint spaces 65%, formation of peripheral bone spurs 35%, subchondral sclerosis 64%, formation of subchondral cysts 15%, formation of bony beaks 25%, joint effusion 2 %.
Conclusion: The results showed that early diagnosis using MRI and X-rays can help identify diseases in their early stages.
The Combination Effect of Daphne Extract and Imatinib on the Antiproliferative Activity of the K562 Cell Line
Authors: Khorshid Alireza , Nojadeh Jafar Nouri , Takanlu Javid Sabour
Published: July 2024

Background: Herbal medicine is well known among the ancient medical sciences. Healing properties have been observed in some species of Daphne. The effect of Daphne plant extract on the K562 cell line has been previously studied, and Gleevec is a well-known and effective drug for the treatment of chronic myelogenous leukemia.
Material and Methods: In this study, the simultaneous effects of using herbal medicine and a targeted therapy drug on the K562 cell line were investigated. The presence of some species of Daphne in Iran motivated us to evaluate the cytotoxic effect of Daphne mucronata on human leukemia cancer cells. The antiproliferative activity of the dichloromethane extract of daphne mucronate (Thymelaeaceae), a new anticancer medicinal plant, was evaluated. Cell viability was quantitated by MTT assay. Apoptotic and necrotic changes in the cell membrane were examined using flow cytometry. Changes in Bax and Bcl2 gene expression were investigated using real-time PCR. The MIC and the IC50 of the crude extract were calculated, and the MIC and IC50 of the combination of the Daphne extract and imatinib were tested in the K-562 cell line.
Results: K-562 cells responded to the extract treatments in a dose-dependent manner, and the increase in the expression of Bcl2 and decrease in the expression of the Bax gene increased with increasing extract concentration. Flow cytometry revealedthat most of the cells underwent apoptosis.
Conclusion: Daphne extract effectively decreased the viability of the cell line. The necrotic effect of the Daphne extract was evaluated, and an increase in the gene expression of Bcl2 was observed in cells exposed to the Daphne extract. The combination of Daphne extracts with imatinib enhances the cytotoxic effect of imatinib.
Physicochemical and Heavy Metal Analysis of River Water for Agricultural Sustainability
Authors: Tadesse Haile Belachew , Ali Nasir , Makuria Megersa Chali , Dinka Waktola Fite
Published: July 2024

Water is essential for human life, agriculture, and the environment. This study examines the physicochemical characteristics and heavy metal levels in the Metti River, located in Dambi Dollo town, Kellem Zone, Ethiopia. Water samples were collected from three sites (upstream, midstream, and downstream) during both dry and rainy seasons. The findings revealed that key parameters were within acceptable limits for drinking and irrigation: temperature (24.8°C – 25.6°C), pH (6.93 – 8.01), electrical conductivity (157.6 μS/cm – 421.3 μS/cm), turbidity (63.8-194.35 NTU), TDS (98.6-146.3 mg/L), DO (8.6-10.2 mg/L), sulfate (39.29-91.64 mg/L), alkalinity (101-120 mg CaCO3/L), nitrate (0.49-1.09 mg/L), nitrite (0.01-0.03 mg/L), chloride (2.83-35.62 mg/L), ammonia (0.95-4.4 mg/L), and phosphate (0.11-0.41 mg/L). However, elevated levels of iron, lead, and manganese may indicate sewage contamination. Despite this, the water quality remains suitable for irrigation and drinking according to WHO/FAO standards. This study underscores the need for continuous monitoring and addressing pollution sources to ensure the river's sustainability for agriculture in the Kellem Wollega Zone.
Statistical Real-time Power Consumption Analysis of Wi-Fi and BLE Scan Operation: A Comparative Study
Authors: Chakraborty Avinanda , Sadhukhan Pampa , Das Pradip K. , Roy Nirmalya
Published: July 2024

The widespread prevalence of Wi-Fi and Bluetooth or its low-power version, Bluetooth low energy (BLE), in modern society has significantly increased their use for setting up wireless connectivity in various Internet-of Things (IoT)-based applications, such as patient monitoring, indoor localization and environment monitoring. The growing demand for integrating efficient power management solutions into these IoT applications has motivated us to focus on the measurement and analysis of power consumption during wireless scan activities using Wi-Fi and BLE since these are crucial for the connection establishment. Although a few research exists on the measurement and analysis of power consumed by wireless technologies like Wi-Fi, BLE and Zigbee in the literature, none have paid attention to the accurate measurement and analysis of real-time power consumption during wireless scan operations at the application level.
To address this gap, we have designed a novel mobile application for the accurate measurement of real-time power consumption during wireless scan operations in order to assess the energy efficiency of various IoT applications involving those wireless technologies. Extensive experimentation was carried out in this study to measure real-time power consumption during Wi-Fi and BLE scans as well as operations without any scans (i.e., no scan) at varying durations and distances of the measuring device from the beacon. Additionally, a comparative statistical analysis of the collected power measurements under three different cases (Wi-Fi scan, BLE scan and no scan) using mean, median and standard deviation was performed to demonstrate the real-time power consumption usage patterns of these operations. This is followed by an insightful discussion on the influence of duration and distance on such power consumption patterns. Furthermore, several avenues for future research based on the findings of this study are also presented here.
Identifying Consumer Preferences for New Generation Vehicles Using Multidimensional Preference Analysis
Authors: Alkan Nesrin , Koksal Can Deniz
Published: July 2024

In recent years, developments in the automotive sector have impacted consumer preferences in transportation, creating more options for consumer needs in this area. Changing consumer needs raises a number of complex issues, such as how automotive companies should develop their products and what actions should be taken to ensure that their brands are popular with consumers and increase their loyalty. It is necessary to investigate the preferences of consumers regarding electric cars, which are expected to be among the types of vehicles that will become increasingly popular in the near future in terms of efficiency and utility. The aim of this study is to investigate consumers’ purchasing processes, to determine the preferred brands and car features in this process and to determine consumers’ expectations of new car models. At the same time, this study aimed to assess car users’ perspectives on electric vehicles and examine participants’ preferences for traditional fuel types such as gasoline, diesel and LPG, as well as electric and hybrid vehicles. The study used a questionnaire to collect data from customers of an automotive company to identify the factors that influence consumer preferences in the automotive sector. As part of the study, a 16-question questionnaire was randomly distributed to 405 respondents. In analysing the data, descriptive statistics were used to determine the demographic characteristics of the participants, chi-square tests were used to examine the relationships between demographic characteristics and factors influencing consumers’ purchasing decisions, and multidimensional preference analysis methods were used to determine the most important and most preferred characteristics of customers when purchasing. The multidimensional preference analysis method, a multivariate statistical method, provides valuable information about the factors that determine consumers’ preferences and decisions. Multidimensional preference analysis provides companies with an important perspective on both competition and the identification of gaps in the market. According to the results of the data analysis, participants indicated that a new generation car should have low fuel consumption and a good safety system. While the environmental friendliness of electric vehicles and the increase in diesel and gasoline prices were the main reasons for their preference, the reasons for nonpreference were problems with recharging.
Combined extraction of manganese during water purification of technogenic solutions
Authors: Dudarev V. I. , Filatova E. G. , Kulkov V. N.
Published: July 2024

A method for demanganization of technogenic aqueous solutions is presented. This method involves electrocoagulation purification of aqueous systems from high metal contents and extraction of manganese (II) ions by carbon sorbent adsorption. A coagulation technology based on electrogenerated aluminum hydroxide was used. According to diffraction analysis, such a hydroxide exhibits an amorphous porous hydrogel structure with a developed sorbing surface. The micellar structure of the as-generated aluminum hydroxide, which was attributed to a modification of gibbsite, is represented by the following colloidal particle: {[m Al(OH)3] nAl(OH)2+ (n-x) OH-}x+ xOH-. The associative process of sorption on gibbsite occurs by dispersion interaction, which is governed by the force of electrostatic attraction of instantaneous and induced dipoles of electrically neutral sorbent molecules and the [Mn (OH2)2(OH)2]0 manganese hydroxo-aquo complex. The adsorption limiting value of manganese ions amounted to 4.9 mmol/g at 298 K and pH 5.8, with  the adsorption equilibrium constant reaching 1.36 . 104. The electricity consumption corresponded to 12.0 А.h at an optimal electrocoagulation duration of 15 min and a current density of 1.6 мА/сm2. The final purification of aqueous solutions using carbon sorbents was conducted in a slightly alkaline medium at pH 7.5. The manganese sorption value reached 1.68 mmol/g. Therefore, the resource-saving effect of processing of technogenic hydro-mineral solution is manifested in a significant reduction of heavy metal salts and in obtaining of demanded mixed coagulants of aluminum and iron sulfates from water purification wastes. Another positive effect of electrochemical water purification consist in water disinfection and its improved ogranoleptic parameters.
On fire risk reduction when operating individual households
Authors: Naumov I. V. , Yamshchikova I. V.
Published: July 2024

The article aims to elaborate a technical means for reducing fire occurrence in internal electrical networks of individual households. General scientific methods of numerical analysis, electric circuit theory, and prediction theory were used. It was determined that the operating mode of the electric network under study is characterized by a significant unbalanced power consumption due to the asymmetry and non-sinusoidality of phase currents caused by the occurrence of additional symmetrical components of forward, reverse, and zero sequences. Additional heat losses increase significantly and lead to overheating of the neutral conductor, thus intensifying fire risks. On the basis of measurements and the authors’ software, a simulation modeling of integration of the developed balancing device into the investigated network was carried out. The conducted analysis found that the developed device can reduce additional heat losses and fire risks by over 90%. Using statistical methods of forecasting, regression analysis in particular, a preventive long-term assessment of the level of additional power losses was conducted. Autoregressive equations for predicting the parameter of additional power losses at a certain probability level were derived. MATLAB graphic editor technologies and Excel software were used to visualize changes in the studied indicators. The results can be used by construction companies when designing the internal electrical network of individual households, as well as for researchers developing approaches to reducing additional losses of electrical energy.
Estudo comparativo da capacidade antioxidante do hidrolisado enzimático das proteínas do Inhame da Costa (Dioscorea cayennensis) e Cará-Moela (Dioscorea bulbifera)
Authors: Silva Raquel Bezerra da , Freitas Maria Eugênia Gouveia de , Gadelha Carlos Alberto de Almeida
Published: July 2024

Os tubérculos do gênero Dioscorea tem relevante importância socioeconômica para a região Nordeste do Brasil, o inhame da costa (Dioscorea cayennensis) é uma hortaliça que apresenta ótimos valores nutricionais e energéticos, importante na dieta da população, já o cará-moela (Dioscorea bulbifera) é uma espécie de limitada comercialização e de pouco conhecimento pelos brasileiros, com familiarização entre curandeiros e donas de casa, que o usam para fins medicinais. Há várias pesquisas envolvendo o gênero que evidenciam os interesses em explorar seus potenciais, por isso, o objetivo deste trabalho é comparar a atividade antioxidantes os hidrolisados obtidos por ação da enzima pepsina, das proteínas biologicamente ativas presentes em tubérculos de D. cayannensis e D. bulbifera e caracterizar o perfil de seus peptídeos bioativos. Assim, fez-se necessário produzir uma farinha fina que foi submetida a extração das proteínas em tampão glicina 0,1 mol/L e em água ultra pura, ambos em pH 9. Determinado o teor de proteínas solúveis pelo método de Bradford (1976) que demonstrou que as proteínas de D. bulbifera se solubiliza melhor em solução tampão de Gly e D. cayannensis em H2O. Os concentrados proteícos foram submetidos à hidrólise com pepsina, e os peptídeos formados foram confirmados em eletroforese de poliacrilamida (Tris-Tricina). A atividade antioxidante foi realizada com o radical de ABTS+ e os resultados constataram que houve relevância do grau de hidrólise das proteínas pela enzima pepsina em relação aos concentrados proteicos, em algumas amostras, e o inhame teve maior capacidade de sequestro do radical se comparado ao cará-moela. Pesquisas como essas agregam valores e contribui para valorização e expansão do conhecimento destas espécies de tubérculos cultivadas e consumidas na região.
Business intelligence competencies and their impact on organizational ambidexterity
Authors: Alabaddi Zaid , Alshweesh Rukana , Almohtaseb Ahmad , Aldehayyat Jehad
Published: July 2024

In Jordan’s banking sector, organizations face the dual challenge of stability and innovation. Achieving this balance requires a deep grasp of leveraging capabilities for existing opportunities and exploring new ones. The key lies at the intersection of business intelligence and organizational ambidexterity. Therefore, this study has investigated the relationship between business intelligence and organizational ambidexterity within the Jordanian banking sector. It examined the impact of managerial, technical, and cultural competencies of business intelligence on organizational ambidexterity in Jordanian commercial banks listed on the Amman Stock Exchange. The quantitative study involved 449 bank employees. The data were gathered via a questionnaire, and the responses were analyzed using R language version 4.2.2. The results indicated that managerial competencies (z = 8.26, p = 0.000) and technical competencies (z = 4.09, p = 0.000) exhibit statistically significant positive direct effects on organizational ambidexterity. Additionally, cultural competencies were found to have a statistically significant direct effect on organizational ambidexterity (z = 2.083, p = 0.037). Managerial, technical, and cultural business intelligence competencies play crucial roles in the adoption of organizational ambidexterity among Jordanian commercial banks. Achieving organizational ambidexterity necessitates integrating these competencies with organizational capabilities.
“Mi trabajo propio”
Authors: Calderón Cisneros Araceli , Escobar Colmenares Sandra
Published: July 2024

El objetivo de este artículo es hacer un acercamiento cualitativo al trabajo de cuidados realizado por mujeres cultivadoras de Chiapas vinculadas a procesos agroecológicos. Se parte del contexto de invisibilización de las mujeres en el ámbito agrícola, donde el trabajo de éstas no se reconoce, se ve sólo como complementario o no se valora lo suficiente. A partir de entrevistas en profundidad a catorce mujeres, se describe su amplia jornada laboral definida por los trabajos de cuidados centrados en la alimentación (entendida de forma amplia, que abarca la producción y la comercialización agrícola, además de la preparación diaria de alimentos), que les deja poco tiempo para su organización o para las actividades de autocuidado. No obstante, las mujeres dotan su trabajo de significados que reivindican el esfuerzo y el aporte para la subsistencia familiar, su contribución al cuidado de la naturaleza y la madre tierra, y como una apuesta política por sus derechos y a favor de la alimentación saludable.
Estudios comparativos entre órdenes religiosas
Authors: González Tristán Juan Bosco
Published: July 2024

El texto analiza el texto editado por José Refugio de La Torre Curiel y Gilberto López Castillo, "Jesuitas y franciscanos en las fronteras de Nueva España, siglos XVI-XIX" y propone a su vez, con base en los ensayos del libro, un acercamiento de tipo comparativo para futuros análisis entre ambas órdenes religiosas o entre corporaciones religiosas en general para la epoca virreinal.
Andrographis paniculata Ethanolic Extract Improved Doxorubicin-induced Cardiac Inflammation, Alterations in Liver Function Parameters and Anemia
Authors: Eziefule Oluebube Magnificient , Arozal Wawaimuli , Wanandi Septelia Inawati , Louisa Melva , Wuyung Puspita Eka , Dewi Syarifah , Nafrialdi Nafrialdi , Dewi Yulia Ratna , Nabillah Deya Adiby
Published: July 2024

Background: Doxorubicin (DOX), an efficacious chemotherapy drug is compromised by cardiotoxicity, myelosuppression, and hepatotoxicity. Due to the limited success of current treatments for DOX toxicity, there is a pressing need to explore alternative medical interventions, particularly from plant sources. This study was conducted to investigate the potential protective effect of ethanolic extract of Andrographis paniculata leaves (EEAP) against DOX-induced cardiac inflammation, liver toxicity, and anemia.Materials and methods: Sprague-Dawley rats were intraperitoneally injected with DOX at a total dose of 16 mg/kgBW. EEAP was administered orally for 4 weeks at doses of 125, 250, and 500 mg/kgBW/day according to the assigned treatment groups. The mRNA expression levels of interleukin-1β (IL-1β) and nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 (NLRP3) in the heart tissue, along with the concentrations of nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) and calcium level were examined. Additionally, the hematological parameters (including hematocrit, hemoglobin and red blood cells (RBCs)), aspartate aminotransferase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), and malondialdehyde (MDA) levels in blood were also analyzed.Results: EEAP dose-dependently decreased the mRNA expressions of IL-1β (p<0.05), tended to decrease mRNA expression of NLRP3 and the concentrations of NFκB and calcium in heart tissue compared with the DOX-only group. Additionally, EEAP dose-dependently decreased ALP values (p<0.0001) and tended to improve hematological parameters, as well as AST and MDA levels in serum.Conclusion: This extract may prevent DOX-induced cardiac inflammation, anemia, and hepatotoxicity. However, further studies are needed to confirm these findings, including the efficacy profile of the extract in cancer rats treated with DOX.Keywords: doxorubicin, Andrographis paniculata, inflammation, anemia, hepatotoxicity, herbal medicine
Metodologia comparativa-culturalista em direito constitucional: modelos de abordagens com México e Colômbia
Authors: Tavares Fernandes dos Santos Beatriz , Lima Jairo , Paschoalini Paiva Leonardo
Published: July 2024

A progressiva demanda por internacionalização da pesquisa científica no Brasil passa, no campo do direito, dentre outras estratégias, também pela utilização de pesquisas comparativas, pois são instrumentos de intercâmbio entre diferentes países. Esse modo de fazer pesquisa jurídica não é novo e, por essa razão, tem sido objeto de aperfeiçoamento do ponto de vista metodológico com o objetivo de ultrapassar as descrições direcionadas exclusivamente aos aspectos formais dos institutos. Por essa razão, buscamos responder à seguinte pergunta/problema: como é possível extrair as maiores potencialidades da pesquisa em direito constitucional comparado? A resposta a essa pergunta se encontra no aparato teórico de Pierre Legrand, o qual indica que a pesquisa comparativa alcança melhores resultados quando é praticada a partir do viés culturalista. Para atingir esse objetivo, apresentamos duas pesquisas que aplicaram as orientações metodológicas de Legrand: uma de análise da transmissão de julgamentos da Suprema Corte do México e outra para o controle prévio de atos de reforma da Constituição na Colômbia. Em conclusão, esses dois casos contribuíram para a demonstração de modelos para a abordagem culturalista em direito constitucional da América Latina.
Bilateral simultaneous partial nephrectomy
Authors: AlTawil M.
Published: July 2024

Introduction. Partial nephrectomy is the treatment of choice for small renal tumors. There are other indications include tumors in a solitary kidney, multiple and bilateral tumors.

Сase presentation. A 67-year-old male presented with left flank pain and lower urinary tract symptoms. Computed tomography for abdominal and pelvis showed bilateral renal masses. After doing the essential laboratory tests and investigations, he underwent bilateral open simultaneous partial nephrectomies. After two days, he was discharged with no complains. Follow-up after three months showed no recurrence and acceptable renal function.

Discussion. Partial nephrectomy is increasingly used for the management of renal masses. The preservation of renal function with reduced morbidity and equivalent oncologic outcomes led to a paradigm shift away from radical nephrectomy.

Conclusion. Bilateral partial nephrectomy is feasible with both clinical and oncological good results.