bluuebunny/crossref_metadata_2025 huggingface dataset:
AVALIAÇÃO DA APRENDIZAGEM: CONCEPÇÕES E ASPECTOS DE LICENCIANDOS DE UM CURSO DE CIÊNCIAS BIOLÓGICAS
Authors: Furtado Cristiane , Wirzbicki Sandra Maria
Published: March 2022

A avaliação da aprendizagem é um dos temas que está presente nas discussões atuais sobre ensino longe de estar esgotado, pois ainda há muito para explorar sobre a temática. Esta pesquisa teve como objetivo principal compreender quais as concepções sobre avaliação da aprendizagem dos licenciandos do curso de Ciências Biológicas da Universidade Federal da Fronteira Sul (UFFS) – Campus Realeza, PR. Na pesquisa foi proposto um questionário para dez licenciandos de cada uma das cinco fases do curso, com o intuito de identificar e analisar quais concepções sobre avaliação da aprendizagem são apresentadas pelos mesmos, posto que estes serão professores e deverão estar preparados para abordar a temática. Com os dados transcritos e analisados por meio da Análise Textual Discursiva, foram identificadas três categorias: I) O que é avaliação? Por que somos avaliados? II) Aspectos positivos e negativos em relação à avaliação e III) Sentimentos envolvidos nos processos avaliativos. Os resultados da pesquisa indicam que existem diferentes concepções da avaliação da aprendizagem dentro do curso, e que os licenciandos não possuem uma concepção fechada sobre o que é avaliação, pois, para muitos, essas questões ainda estão em construção.
Una propuesta interdisciplinar para trabajar la competencia digital docente en el Grado de Educación Infantil (UPV/EHU)
Authors: Álvarez Uría Amaia , López-de-Arana Prado Elena , Sáenz-del-Castillo Velasco Aritza
Published: March 2022

En la pandemia acontecida en este nuevo milenio ha quedado patente la presencia e importancia de las Tecnologías de la Información y la Comunicación en el día a día, incluso de la primera infancia. Es por ello que la formación inicial del profesorado debe tener en cuenta el desarrollo de la competencia digital docente (CDD). Por este motivo, en el segundo curso del Grado de Educación Infantil se plantea un módulo multidisciplinar denominado: “Influencia de las Pantallas en la Infancia”. En este estudio de caso se examina si esta propuesta facilita el desarrollo de la CDD. La muestra está constituida por 166 estudiantes universitarios. Se ha analizado el contenido de los mapas conceptuales digitales en relación con la reflexión del alumnado sobre la influencia de las pantallas. El análisis de las presentaciones orales de sus conclusiones se ha realizado a través de una escala de observación y otra de autoevaluación. Del análisis realizado se concluye que la CDD de los futuros docentes ha sido satisfactoriamente desarrollada. Aunque también queda claro que la posibilidad de transferir estos resultados dependerá de futuras investigaciones ubicadas en contextos diferentes, que utilizan otros interfaces, o relacionadas con otros Grados.
A governança do turismo religioso na pandemia da Covid-19:
Authors: Sartori Anderson
Published: March 2022

A pandemia provocada pela Covid-19 modificou as formas de conviver em sociedade, com a necessidade de protocolos o enfrentamento da doença. As restrições de deslocamentos e aglomerações trouxeram impactos pelo mundo com diferentes planejamentos, de acordo com as políticas implementadas em cada país. O turismo foi afetado diretamente com a pandemia, com consequências que serão mensuradas de forma adequada. O turismo religioso, por envolver elementos materiais e imateriais do sagrado, como também aglomerações devido aos rituais e cultos, teve seus destinos e atrativos restritos ao acesso de fiéis, turistas e peregrinos por meses no Brasil, dependendo o estado. Dentro desse quadro de limitações geradas a partir de 2020, o objetivo deste trabalho foi analisar as estratégias de governança do turismo religioso no contexto da pandemia da Covid-19 no município de Nova Trento, em Santa Catarina/Brasil. A pesquisa é caraterizada como qualitativa, exploratória, com delineamento de estudo de caso, com uso de referencial bibliográfico e documental como fontes e análise do discurso. Os resultados apresentam a ausência de articulação em rede na governança do destino, com as instituições religiosas definindo suas estratégias e medidas para manutenção do contato com os fiéis. O processo de retomada do turismo também não foi articulado com as instâncias de governança, com a manutenção das transmissões on-line das celebrações, mesmo com a presencialidade nos templos. A dificuldade de acesso a fontes é considerada uma fragilidade e o aprofundamento de pesquisas sobre a governança neste destino sobre o turismo religioso é uma das sugestões para novos trabalhos.
Turismo e Religiosidade:
Authors: Augusta Freitas Costa Canal Maria , Santos de Castro Milene de Cássia , Da Silva Palheta Hygo
Published: March 2022

A festa enquanto objeto de análise do turismo apresenta-se como evento compreendido como vetor multiplicador de negócios, capaz de atrair fluxo de turistas e impactar a dinâmica social. Numa dimensão mais abrangente, a festa permite evidenciar elementos vivenciados no fazer festivo que revelam dimensões das relações de territorialidades humanas, aspectos vinculantes da viagem turística como processo de descoberta e do encontro com o outro. Na Amazônia a festa aparece como expressão da religiosidade de suas territorialidades, oportunizando aos turistas e visitantes a possibilidade de realização de turismo religioso por meio da vivência da experiência turística através do fazer festivo. Objetivamos discutir a religiosidade devota do fazer festivo na Amazônia em espaços de turismo cultural religioso, refletindo sobre as modificações e adaptações desse fazer devido à pandemia de COVID-19. Assim, o     recorte da pesquisa se dimensiona pelas festas paraenses: do Sairé e da Marujada, tendo por base a metodologia qualitativa com: levantamento bibliográfico e documental, trabalhos de campo com observação dirigida e entrevistas semiestruturadas.
Palavras-chave: Festa. Religiosidade. Turismo Religioso. Covid-19. Pará.
THE BASQUE GUARANTEED LIVING INCOME AND SOCIAL INCLUSION SCHEME AS A MODEL FOR A UNIVERSAL LABOUR GUARANTEE
Authors:   Universidad de Deusto, Bilbao, España, Arrieta Idiakez Francisco Javier
Published: March 2022

This study first defines the scope of the concept of a Universal Labour Guarantee to include social protection. To do so, it considers the guidelines provided by both the International Labour Organisation and the European Union. The Basque Guaranteed Living Income and Social Inclusion Scheme is then analysed as a practical expression and illustration of the concept of a Universal Labour Guarantee.
Flavonoids: The Innocuous Agents Offering Protection against Alzheimer’s Disease Through Modulation of Proinflammatory and Apoptotic Pathways
Authors: Biswas Moumita , Das Aritrajoy , Basu Soumalee
Published: March 2022

Background:

Beginning from mild cognitive impairment in patients suffering from Alz-heimer’s disease (AD), dementia sets in with the progress of the disease. The pathological changes in the brain begin fifteen to twenty years before AD related dementia develops. Presence of senile plaques and neurofibrillary tangles are considered the hallmarks of AD brain. Chronic inflammation resulting from the disruption of the equilibrium between anti-inflammatory and pro-inflammatory signalling emerges as another important feature of AD and also other neurodegenerative diseases. Substantial studies demonstrate that this sustained immune response in the brain is associated with neuronal loss, along with facilitation and aggravation of Aβ and NFT pathologies. Although it is well accepted that neuroinflammation and oxidative stress have both detrimental and beneficial in-fluences on the brain tissues, the involvement of microglia and astrocytes in the onset and progress of the neurodegenerative process in AD is becoming increasingly recognized. Although the cause of neuronal loss is known to be apoptosis, the mechanism of promotion of neuronal death remains un-disclosed.

Objective:

Controlling the activation of the resident immune cells and/or the excessive production of pro-inflammatory and pro-oxidant factors could be effective as therapeutics. Among the phytonu-trients, the neuroprotective role of flavonoids is beyond doubt. This review is an exploration of the literature on the role of flavonoids in these aspects.

Conclusion:

Flavonoids are not only effective in ameliorating the adverse consequences of oxida-tive stress but also impede the development of late onset Alzheimer’s disease by modulating affect-ed signalling pathways and boosting signalling crosstalk.
Research Progress of Organic Carbon Nanotubes-Modified Metal-
Composite Photocatalytic Materials in Water Treatment
Authors: Xie Shiyu , Li Xiang , Zheng Hengwei , Feng Li , Khan Sarfaraz
Published: March 2022

In recent years, organic Carbon Nanotubes (CNTs) have attracted wide attention because
of their excellent and unique properties in electrical, optical, mechanical, and other fields, as well as
their potential application in the water treatment field. Metal-composite photocatalysts generally
have the problems of electron-hole recombination, which seriously affect their photo-catalytic performance.
It was found that the surface modification of metal-composite photocatalyst using organic
carbon nanotubes could effectively improve the photo-catalytic activity and stability of metalcomposite
photocatalyst materials. This paper aims to provide the current research progress of organic
carbon nanotubes-modified metal-composite photo-catalytic materials in water pollution control,
including the preparation methods of organic carbon nanotubes and their modified metal-composite
photocatalysis materials, as well as the applications of organic carbon nanotubes-modified metalcomposite
photocatalytic materials in water pollution control field. Concluding remarks and future
trends are also pointed out. This paper can provide guidance for designing high-performance carbon
nanotube metal-composite photo-catalytic materials.
Prediction of Drug Bioactivity in Alzheimer’s Disease Using Machine
Learning Techniques and Community Networks
Authors: S. Hemkiran , G. Sudha Sadasivam
Published: March 2022

Background:

The design of novel drugs is vital to combat fatal diseases such as Alzheimer’s.
With quantum advances in computational methods, artificial intelligence (AI) techniques have been
widely utilized in drug discovery. Since drug design is a protracted and resource-intensive process, extensive
research is necessary for building predictive in-silico models to discover new medications for
Alzheimer’s. A thorough analysis of models is, therefore, required to expedite the discovery of new
drugs.

Objective:

In this study, the performance of machine learning (ML) and deep learning (DL) models for
predicting the bioactivity of compounds for Alzheimer’s inhibition is assessed. Additionally, an interaction
network is constructed to visualize the clustered bioactivity networks.

Methods:

The dataset was initially prepared from a public repository of bioactive compounds and was
curated. Exploratory data analysis was performed to get insights into the gathered data. A bioactivity interaction
network was then constructed to detect communities and compute the network metrics. Next,
ML and DL models were built, and their hyperparameters were tuned to improve model performance.
Finally, the metrics of all the models were compared to identify the best-performing model for bioactivity
prediction.

Results:

The bioactivity network revealed the formation of three communities. The ML models were
ranked based on lower error scores, and the best five models were hybridized to create a blended regressor.
Subsequently, two DL models, namely a deep neural network (DNN) and long short-term memory
with recurrent neural network architecture (LSTM-RNN), were built. The analysis revealed that the
LSTM-RNN outperformed all the models analysed in this study.

Conclusion:

In summary, this study illustrates a bioactivity network and proposes a DL technique to
build robust models for in-silico prediction of drug bioactivity against Alzheimer's.
Treatment of Primary Dysmenorrhea Affecting Menstruating Women
Using Herbs: A Review
Authors: Por Choo Shiuan , Rajagopal Mogana Sundari , Akowuah Gabriel Akyirem , Chinnappan Sasikala , Abdullah Nor Hayati
Published: March 2022

Primary dysmenorrhea is a common condition that affects menstruating women, especially
young women. Painful cramping in the lower abdominal area, nausea, vomiting, headache, and fatigue
is associated with primary dysmenorrhea, which restricts women from normal living life. The productivity
and work performance of women are heavily affected by the symptoms of primary dysmenorrhea.
Non-steroidal anti-inflammatory drugs (NSAIDs) and low dose oral contraceptive pills (OCPs)
are commonly prescribed for the treatment of primary dysmenorrhea. However, variability in individual
response to the drugs and their side effects hinder their long-term use among women. Complementary
medicine such as herbs is a promising alternative for the treatment of primary dysmenorrhea, but
it lacks scientific evidence. The pharmacological and clinical studies of 9 herbs were included in this
review. Although excellent analgesic effects of herbs were reported by clinical studies, the detailed
mechanism of action of most herbs remains unelucidated. Several studies discovered that herbs exert
analgesic effects through direct uterine muscle relaxation effect, inhibition of cyclooxygenase-2
(COX-2), inhibition of intracellular calcium level, and reduction of prostaglandin synthesis. Further
investigation of pharmacological action and the recommended dosages of the herbs for the optimal
analgesic effect is needed.
An Image-Based Information Hiding Approach with Chaotic Systems and
Optimized Security
Authors: Saliban Abdiqani A. , Song Yinglei
Published: March 2022

Background:

Recently, information hiding has become an important approach to securely
storing and transmitting important information in digital media.

Objectives:

This paper proposes a new approach to hide information in a color image with optimized
security.

Methods:

The approach performs the hiding in two phases. Firstly, the information that needs to be
hidden in an image is represented by a sequence of binary bits, and the sequence is shuffled and encrypted
with a set of three-dimensional chaotic systems. Secondly, the binary bits in the shuffled
and encrypted sequence are hidden into the R, G, and B components of the pixels in the given color
image with a dynamic programming approach.

Results:

Experimental results show that the proposed approach can securely hide information in a
color image without generating significant changes in the visual contents of a color image. The
analysis also shows that the proposed approach is robust against potential attacks.

Conclusion:

The proposed approach is thus practically useful for applications aimed at image-based
information hiding.
Implementing Gender Mainstreaming in Indonesian Local Government: The Case of Tangerang Regency
Authors:   Universitas Pembangunan Nasional Veteran Jakarta, Nurdin Nurdin
Published: March 2022

This research is about the implementation of gender mainstreaming policies in local governments in Indonesia since the enactment of Presidential Instruction No. 9 of 2000 on Gender Mainstreaming in National Development. After running for almost two decades, the implementation of gender mainstreaming has not succeeded in having a significant impact in realizing gender equality in Indonesia in general and Tangerang Regency in particular. Indicators of poverty, domestic violence, and unemployment are still experienced by women. The low index of gender empowerment and women's representation in politics is another indicator that shows the failure of gender mainstreaming in development. Gender inequality in development is caused by internal and external factors that directly impact the achievement of gender equality. Internal factors refer to the low political commitment of regional leaders in initiating the making and stipulation of local regulations on gender mainstreaming in development. Meanwhile, external factors refer to the strong patriarchal culture in Indonesian society which still views women as incapable of political leadership and policy making
A rare case of unilateral acute posterior multifocal placoid pigment epitheliopathy with features of Vogt-Koyanagi-Harada disease
Authors:   Department of Ophthalmology, Institute of Medical Sciences and SUM Hospital, Siksha O Anusandhan (Deemed to be University), Bhubaneswar, India, et al. Panigrahi
Published: March 2022

The purpose of this study is to report a rare case of unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with features of Vogt-Koyanagi-Harada (VKH) disease. Both the diseases have their own unique presentations and can lead to vision loss in the affected eye. Overlapping features of both diseases in the same eye is rare. A 28-year-old healthy female presented with loss of vision in her right eye for 10 days duration. Visual acuity in the affected eye was 20/200, N36. Fundus examination revealed numerous creamy yellow lesions overlying the posterior pole with subretinal fluid. Further investigations including fundus fluorescein angiography and optical coherence tomography were suggestive of overlapping features of both APMPPE and VKH disease. Baseline laboratory investigations and markers for Sarcoidosis, Tuberculosis, and Syphilis were normal. The patient was treated with tapering doses of oral steroids. One month following initiation of treatment, the vision had improved to 20/20, N6 with complete resolution of subretinal fluid in the right eye. The overlapping clinical and imaging features suggest that both diseases may be a part of a common inflammatory process that secondarily damages the outer retinal structures.
Root cause qualitative analysis of acute childhood poisonings as a study of sentinel surveillance
Authors: Modesto Mirella Machado Ortiz , Carvalho de Lima Paola Kallyana Guarneri , Gavioli Aroldo , Hungaro Anai Adari , Modesto Gabriel da Silva , Zani Adriana Valongo , Marcon Sônia Silva , De Oliveira Magda Lúcia Félix
Published: March 2022

Objective: To analyze the root cause of occurrences of severe intoxication in children and adolescents from the perspective of sentinel events. Methods: Observational, retrospective, and qualitative study of a series of cases of seven children and young people with a confirmed clinical picture of intoxication by various agents, treated in a stabilization room of emergency care units or intensive care, and notified to toxicological information and assistance center from January to June 2019. The epidemiological surveillance of sentinel events was used based on a review of hospital documents and in-depth interviews with family members. The Root Cause Analysis (RCA) matrix was used to evaluate the cases and the systematic reconstruction of the cases' antecedents.Results: The age profile of the study population, the pattern of agents and substances involved - poisoning by intentional ingestion in five (71%) cases, indicated critical points and missed opportunities for prevention. The individual and family history analysis indicated as direct causal factors the deviations from norms for preventing poisoning at home or in the family context for all cases.The prevention and health promotion activities in the health services constituted the underlying causes of the occurrences.Conclusion: The root cause analysis identified a deficiency in public policies, but the interface between education, public security, social assistance, economy, and health policies would be preponderant for preventing childhood and youth poisoning.
Thermo-rechargeable Batteries Fabricated Using Low-cost Materials
Authors:   Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Japan, Widdhiarta Arnold Hendharto , Shimaura Yousuke ,   Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Japan, Nagai Ichiro ,   Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Japan, Shibata Takayuki ,   Faculty of Marine Technology, Tokyo University of Marine Science and Technology, Koto-ku, Japan, Moritomo Yutaka ,   Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Japan,   Graduate School of Pure and Applied Science, University of Tsukuba, Tsukuba, Japan,   Tsukuba Research Center for Energy Materials Science (TREMS), University of Tsukuba, Tsukuba, Japan
Published: March 2022

We fabricated three thermo-rechargeable batteries using low-cost transition metal hexacyanoferrate and determined the thermal voltage (Vcell) and discharge capacity (Qcell) per unit weight of the total active material in the cathode and anode. The obtained values were compared with the calculated values, which were determined by analyzing the temperature and capacity coefficients of the redox potential.
Remote Controlled Rover Using Rocker Bogie Mechanism
Authors: Badgujar Nilesh , Mahale Mohit , Dani Shreya , Bharati Tribhuvan , Mansuri Prof. Iqbal
Published: March 2022

Abstract: The rocker-bogie suspension system has robust capabilities to deal with uneven terrain becauseof it’s distributing the payload over its six wheels uniformly. Most of the cover designs have been developed for Mars and Moon surface in order to understand the geological history of thesoil and rocks. Exploration operations need high speed and long distance traversal in a short mission period due to environmental effects, climate and communication restrictions In this research, a new suspension mechanism has been designed and its kinematic analysis results were discussed. One of the major shortcomings of current Rocker-Bogie rovers is that they areslow. In our project, we have focused on six-wheeled rocker bogie suspension system design which has advantage of linear bogie motion in protecting the whole system from getting rollovers during high- speed operations. This has greatly increased the reliability of structure on rough terrains and also enables its higher speed exploration with same obstacle height capacity as twice the diameter of wheel. The project aims to improve some basic working so that it can perform in a better way.
Cooperation Prospects between the EAEU Member States in the Field of Information Security
Authors: Ilyina M. Yu.
Published: March 2022

ABSTRACT The article examines the global challenges facing the Eurasian Economic Union (EAEU) associated with significant progress in the development of information and communication technologies (ICT) and tools that form the international information space, and suggests directions for integration to overcome them. The rapid build-up by the countries of the world of their potential in the field of ICT predetermines the strategic nature of the advanced cooperation of the EAEU member states in the field of information security.

Aim. Determine the opportunities and prospects for cooperation between the EAEU Member States in the field of information security in the context of unprecedented digitalization of all spheres of life, due to the rapid development of ICT, while the Treaty on the EAEU of May 29, 2014 does not provide for information security issues.

Tasks. Consider the existing regulatory framework for bilateral and multilateral relations of the EAEU countries in the field of information security, determine the vector, priorities of the EAEU countries in building their national policies in the field of international information security with integration partners and the world community.

Methods. In this paper, using the methods of logical and deductive analysis, possible conditions for cooperation between the EAEU countries in the field of international information security are identified to overcome global challenges and threats and ensure the post-cuperation development of Eurasian integration.

Results. The study showed that today information security is not only a necessary condition for ensuring national sovereignty in the economic sphere, but these are issues of ensuring the independence of the state in the social, cognitive, military and political spheres. When considering the EAEU as one of the leading centers of power in the polycentric world, it is necessary to improve the existing paradigm for the development of Eurasian integration, laid down by the Treaty on the EAEU of May 29, 2014, in order not to be in conditions of unjustified expectations, providing for the involvement of issues of a new quality and character.

Conclusion. Considering that information policy issues are not regulated by the Treaty on the EAEU of May 29, 2014, seems justified and a very timely launch of the process of considering the possibility of creating a high-level working group on the formation of the Eurasian agenda in the field of international information security.
VIOLÊNCIA DE GÊNERO NUMA UNIVERSIDADE PÚBLICA BRASILEIRA: SAINDO DA INVISIBILIDADE
Authors: Garcia Montrone Aida Victoria , Cangiani Fabbro Marcia Regina , Martins Dias Teresa Cristina , Fusari Lívia Maria , Barboza Moreira Diogo
Published: March 2022

Pesquisa descritiva-transversal/inferencial em universidade pública do interior de São Paulo. Objetivo: mapear violência de gênero; verificar a probabilidade de um/a estudante a sofrer. Método: questionário on-line enviado para estudantes de cursos presencias, entre maio-outubro/2018. Análise utilizou frequência, correspondência múltipla e modelo de regressão logística. Resultados: 84% tinham menos de 26 anos, 70% se declararam brancos; 68% heterossexuais e 59% feminino cis. Há desconhecimento dos tipos de violência de gênero reconhecidos e poucos/as estudantes a reportaram por não saber como fazê-lo. Estudantes mulheres, negras e homossexuais têm probabilidade seis vezes maior de sofrer violência, em comparação a homens, brancos e heterossexuais.
A DIMENSÃO POLÍTICA DAS VESTES DE BABADO E AMOR: VIOLÊNCIAS E RESISTÊNCIAS
Authors: Souza Campos Baga de Bagaceira , Pitombo Cidreira Renata
Published: March 2022

Este trabalho traz inquietações que visam compreender a dimensão política das vestes de Babado e Amor, corpos queers. Na relação entre seus corpos vestimentados e as cidades de Cachoeira e São Félix, interior da Bahia, buscamos abordar aspectos sensivelmente políticos a partir de uma discussão em que imperam os processos de violência e resistência envolvidos em suas estéticas adornadamente desobedientes. A metodologia aplicada foi revisão bibliográfica dos estudos pós-estruturalistas e da produção de imagens enquanto ferramentas perceptivas da potência midiática do vestir
“TRISTE, LOUCA OU MÁ”: REFLEXÕES EM TORNO DE MULHERES TRANSGRESSORAS NA PÓS-GRADUAÇÃO
Authors: De Lima Neto Avelino Aldo , Xavier da Costa Maria Carolina
Published: March 2022

Este estudo objetivou compreender como determinados discursos classificam mulheres estudantes de pós-graduação como transgressoras de papéis de gênero. Trata-se de uma pesquisa qualitativa que se utilizou análise documental, apreciação de imagens e entrevistas para a construção dos dados. Estes foram interpretados de referencial teórico-metodológico foucaultiano. Os resultados apontaram que os discursos perpassam e se repetem ao longo da história, sendo as mulheres protagonistas de atos de transgressão das normas do patriarcado.
Pengembangan Multimedia Interaktif Menggunakan 3D Pageflip Professional pada Materi Penentuan Jenis Kelamin Serangga untuk Kelas XII SMA
Authors: Rahmi Yusar , Johari Asni , Sadikin Ali
Published: March 2022

This study aims to develop interactive multimedia-based learning media using 3D Pageflip Professional. The developed media discuss material about determining the sex of insects, this research belongs to the Research and Development (R & D) type using the ADDIE method. The research was conducted at SMA N 10 Jambi City in September 2021. The research data was obtained by distributing questionnaires via google form to students and teachers of biology subjects. Data analysis techniques were carried out qualitatively and quantitatively. The results of validation by material experts and media experts stated that this media was categorized as "very good". The test results on students (small groups and large groups) and teachers, stated that interactive multimedia-based learning media using 3D Pageflip Professional was categorized as "very good". Based on this, it can be concluded that the product is feasible to be used as a learning medium.
Key words: Learning media, 3D Pageflip Professional, insect sex determination, interactive multimedia
 
Abstrak. Penelitian ini berutujuan untuk mengembangkan media pembelajaran berbasis multimedia interaktif menggunakan 3D Pageflip Professional. Media yang dikembangkan membahas materi tentang penentuan jenis kelamin serangga, penelitian ini termasuk ke dalam jenis  Research and Development ( R & D ) menggunakan metode ADDIE. Penelitian dilakukan di SMA N 10 Kota Jambi pada September 2021. Data penelitian diperoleh dengan menyebarkan angket melalui google form kepada siswa dan guru mata pelajaran biologi. Teknik analisis data dilakukan secara kualitatif dan kuantitatif. Hasil validasi oleh ahli materi dan ahli media menyatakan bahwa media ini terkategori “sangat baik”. Hasil uji coba kepada siswa (kelompok kecil dan kelompok besar) dan guru, menyatakan bahwa media pembelajaran berbasis multimedia interaktif menggunakan 3D Pageflip Professional terkategori “sangat baik”. Berdasarkan hal itu dapat disimpulkan bahwa produk layak digunakan sebagai media pembelajaran.
Kata kunci: Media pembelajaran, 3D  Pageflip Professional, penentuan jenis kelamin serangga, multimedia interaktif
ANALISIS PREFERENSI KONSUMEN HOTEL DENGAN METODE KANO BERDASARKAN DIMENSI SERVQUAL
Authors: Soetaryo Endah Utami , Lawalata Rezki Fadhli
Published: March 2022

Peneltian ini bertujuan untuk mengetahui preferensi konsumen terhadap layanan suatu Hotel di kawasan Malioboro Yogyakarta. Berawal dari permasalahan terjadinya penurunan tingkat hunian yang terjadi selama tiga tahun berturut-turut serta adanya beberapa keluhan konsumen yang diperoeleh dari kotak saran dan aplikasi pemesanan hotel maka penelitian ini perlu dilakukan. Adapun metode yang digunakan adalah Metode Kano. Pengumpulan data dengan menggunakan kuesioner Kano yang terdiri dari kuesioner Functional dan kuesioner Dysfunctional. Jumlah sampel dalam penelitian ini sebanyak 120 responden dan teknik sampling dengan Purposive Sampling. Berdasarkan hasil penelitian, atribut layanan yang termasuk kategori Must Be yaitu hotel memiliki Swimming Pool, CaféBar bersih dan nyaman, karyawan berpakaian rapi, mampu menjaga privasi, bersedia menanggapi kritik dan saran, proses reservasi mudah, petugas parkir selalu dapat membantu. Atribut yang termasuk kategori One Dimensional yaitu interior menarik dan instagrammble, kamar dilengkapi lemari es, kondisi kamar dan Bathroom bersih dan nyaman. Atribut kategori Attractive adalah hotel tersedia fasilitas gym.
Paisagens do vinho e enoturismo: experiências de alto valor
Authors: Valduga Vander , Gabardo Wagner Otavio , Sperandio Garcia Gimenes Minasse Maria Henriqueta
Published: March 2022

O objetivo deste trabalho é discutir o caráter multidimensional da experiência em enoturismo e compará-lo com depoimentos de enoturistas sobre experiências memoráveis em paisagens do vinho. A pesquisa qualitativa foi realizada por meio de análise de conteúdo de depoimentos de 21 enoturistas que narraram uma experiência inesquecível de visita a uma vinícola. Os dados revelaram que, para um enoturista experiente, as dimensões do prazer e do saber coexistem. Os valores de uma experiência dita autêntica são marcados pela convivialidade com os atores da vitivinicultura; pela aquisição de novos conhecimentos interagindo com um enólogo; pela oportunidade de provar um vinho em processo de elaboração; e pelo prazer estético (visual e gustativo) emanado pelo vinho e seu entorno produtivo. Conclui-se ainda que a paisagem do vinho é portadora de sentimentos, capazes de impactar e emocionar o sujeito que as vivencia.
Ethanol Extract of Miana Leaf (Coleus atropurpureus Benth) As Analgetic Antiinflamation in Rats (Rattus novergicus)
Authors: Sukmawati  , Santi Irma , Wati Aulia , Aulya Riska
Published: March 2022

Background: Inflammation is a normal protective response to tissue injury caused by physical trauma, chemicals, or microbiological substances. The manifestation clinic of inflammation is pain. Miana leaves (Coleus atropurpureus Benth.) have chemical contents such as essential oils, phenols, flavonoids, and polyphenols. Flavonoids can protect lipid membranes from damage and inhibit cyclooxygenase, which is the first pathway for the synthesis of pain mediators such as prostaglandins. Objectives: This study aims to determine the effectiveness of ethanol extract of Miana leaves (Coleus atropurpureus Benth) (EEML) as analgesic and anti-inflammatory in rats (Rattus novergicus). Material and Methods: This study used The Pre-Posttest-Only Control Group Design,  twenty male rats were divided into 5 groups namely negative control, positive control was given diclofenac sodium, treatment with EEML dose of 150 mg/kgBW, 300 mg/kgBW, and 600 mg/kgBW. Test of Antiinflammatory uses the Rat Hind Paw Edema method where the condition of inflammation in rats is induced with 5% egg white by subplantar. The measurement of edema in rat feet used a caliper every 30 minutes for 5 hours. While The measurement of analgesic testing used the method of nociception test which evaluates pain responses such as Staggering Gait, Vocalization, and Writhing. Results: The results of the measurement of the inflammatory parameters were analyzed with the One Way Anova test for the width of edema foot and Kruskal Walis for the thickness of edema foot. While the results of observing the pain response were analyzed with the Kruskal Walis test. Conclusions: This study concluded that the ethanol extract of Miana leaves has anti-inflammatory analgesic especially at a dose of 600 mg/kg BW which results are non-significant (p> 0.05) with a positive control group (sodium diclofenac).
Metástasis pulmonar y pleural en cáncer de pene, una patología infrecuente
Authors: Reyes Peña Sonia Elizabeth , Vargas Rodríguez Ledmar Jovanny , Rozo Ortiz Edwar Jassir , Arias Duarte Miguel Leonardo
Published: March 2022

Introducción: El carcinoma de pene es un tumor infrecuente en nuestro medio con menos del 1% de muertes en el hombre. Se define como el proceso proliferativo y desordenado de las células epiteliales escamosas del pene.

Objetivo: Presentar el caso de un paciente que presentó cáncer de pene con metástasis a pulmón.

Caso clínico: Paciente de 85 años ingreso por cuadro clínico de 24 horas de evolución consistente en hematuria asociado a tos no productiva, lumbalgia, astenia y adinamia. Tenían antecedentes de carcinoma escamosos de pene, fumador pesado hasta hace dos años, exposición crónica a humo de leña. Al examen físico con regular estado general, ruidos respiratorios sugestivos de hipoventilación izquierda, ausencia de pene por antecedentes y sonda vesical salida de orina hematúrica, ganglios en región inguinal, edema en miembros inferiores con formación de flictenas en cara dorsal de los pies. Los estudios imagenológicos confirmaron la presencia de masa a región pulmonar junto con fracturas patológicas a nivel torácico, por lo que se dio manejo paliativo con egreso hospitalario.

Conclusiones: El cáncer de pene es una patología de baja prevalencia a nivel mundial. Aproximadamente el 95% de estos canceres son carcinomas de células escamosas que fácilmente pueden diseminarse localmente a través de canales linfáticos o vasculares, a pesar de ello, la probabilidad de enfermedad metastásica es rara, y afecta principalmente a órganos como el hígado, los huesos y al cerebro, sin embargo, se han reportado pocos casos de metástasis a columna dorsal, corazón, retroperitoneo, tejido mamario masculino, pulmón y metástasis cutáneas.
Effect of phosphorylation on the structural dynamics and thermal stability of human Dopamine Transporter: a simulation study using Normal Modes, Molecular Dynamics and Markov State Model
Authors: Quiroz Roberto , EA Philot, , Perahia David , SCOTT ANA LÍGIA
Published: March 2022

The Human Dopamine Transporter (hDAT) plays an essential role in
modulating the Influx/Efflux of dopamine, and it is involved in the
mechanism of certain neurodegenerative diseases such as Parkinson’s
disease. Macromolecules adopt many conformations in solution depending
on their structure and shape, which determine their dynamics and
function. In this context, several studies have reported important
meta-states for Dopamine transport: outward-facing open state (OFo), the
outward-facing closed state (OFc), the holo-occluded state closed
(holo), and the inward-facing open state (IFo). Furthermore,
experimental assays have shown that different phosphorylation conditions
can affect the rate of dopamine absorption. This work presents a
protocol using hybrid simulation methods to study the conformational
dynamics and stability of meta-states of hDAT under different
phosphorylation states. With this protocol, we explored the
conformational space of hDAT, identified the meta-states, and evaluated
the free energy differences and the transition probabilities between
them in each of the phosphorylation cases. We also presented the
conformational changes and correlated them with those described in the
literature. The results suggest that the phosphorylation corresponding
to NP-333, where (all sites
[Ser/Thr](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4380854/)
from residue 2 to 62 and residue 254 to 613 are phosphorylated, except
residue 333) is the one that would affect dopamine transport the most,
corroborating the experimental results. Furthermore, our results showed
that just single phosphorylation/dephosphorylation could alter intrinsic
protein motions affecting the sampling of one or more meta-states
necessary for dopamine transport. In this sense, the modification of
phosphorylation influences protein movements and conformational
preferences, affecting the stability of meta-states and the transition
between them and, therefore, the transport.
Novel predictor for new-onset atrial high-rate episode in patients with dual-chamber implantable cardiac devices
Authors: Nishinarita Ryo , Niwano Shinichi , Oikawa Jun , Saito Daiki , Sato Tetsuro , Matsuura Gen , Arakawa Yuki , Kobayashi Shuhei , Shirakawa Yuki , Horiguchi Ai , Nakamura Hironori , Ishizue Naruya , Kishihara Jun , Fukaya Hidehira , Ako Junya
Published: March 2022

Introduction The incidence of new-onset atrial high-rate episode (AHRE)
is higher among patients with cardiac implantable electronic devices
(CIEDs) than in the general population. We sought to elucidate the
clinical factors including P-wave dispersion (PWD) in sinus rhythm
associated with AHRE in CIED patients. Methods and results One hundred
one patients with newly implanted CIEDs from 2010 to 2014 at our
institute were included. PWD was measured at the time of device
implantation via a body-surface electrocardiogram. AHRE was defined as
any episode of sustained atrial tachyarrhythmia (>170 bpm)
recorded in the device’s memory. Patients were divided into an AHRE
group (n=34) and non-AHRE group (n=67) in accordance with the presence
or absence of AHRE within one year of device implantation and compared.
The mean age was 75 ± 11 years old. A greater incidence of sick sinus
syndrome (p=0.05) and longer PWD (62.6 ± 13.1 vs. 38.2 ± 13.9 ms;
p<0.0001) were apparent in the AHRE group. Multivariate
analysis revealed that PWD was an independent predicting factor for
new-onset AHRE (odds ratio: 1.11; 95% confidence interval: 1.06–1.17;
p<0.0001). In the logistic regression analysis, the
receiver-operating characteristic curve (area under the curve: 0.90;
p<0.001) suggested the best cutoff value for PWD was 48 mm,
achieving a sensitivity of 73.8% and specificity of 77.9%. Conclusion
PWD is a simple but feasible predictor for new-onset AHRE in patients
with cardiac implantable electronic devices.
Blow-up result for a semilinear double-wave equation with a nonlinear term
Authors: Ouyang Baiping , Liu Yan
Published: March 2022

In this paper, we study the blow-up of solutions to a semilinear
double-wave equation with a power nonlinear term. By establishing an
auxiliary function and using iteration methods associated with a
differential inequality technique, the estimates of lifespan and blow-up
of solutions are obtained.
ASSOCIATION BETWEEN BLOOD GLUCOSE LEVEL AT THE TIME OF BLOOD CULTURE SAMPLING AND CULTURE POSITIVITY IN A MEDICAL INTENSIVE CARE UNIT: A PROSPECTIVE OBSERVATIONAL STUDY
Authors: yildirim suleyman , Yilmaz Huseyin O. , Durmaz Yusuf , Kirakli Cenk
Published: March 2022

Introduction Sepsis is one of the major causes of death in intensive
care unit (ICU). One of the most important treatment for sepsis is
antibiotic treatment. At the beginning antibiotics is chosen empirically
after that is changed according to culture results or response to
initial treatment. Nevertheless, only small number of culture positivity
can be detected. The factors associated culture positivity are of
interest in the critically ill patients. Therefore, we aim in our study
to explore the factors associated with blood culture positivity
especially blood glucose levels at the time blood culture sampling.
Methods We perform this prospective observational study at the Intensive
Care Unit of Dr. Suat Seren Chest Disease and Chest Surgery Training and
Research Hospital between August 1, 2016 and January 1, 2017, in İzmir,
Turkey. Two separate samples from opposite sides of each patient were
obtained, and blood glucose was measured simultaneously with bed-side
blood glucose measurement device by using the blood drawn for blood
culture for each vial. The average of the two measurements was
considered as the simultaneous blood glucose level of the patient.
Results 174 patients were enrolled into the study, blood culture
positivity was detected in 53 (30%) patients. In univariate analyzes,
blood glucose levels, presence of central venous catheter, antibiotic
treatment, vasoactive drug infusion and diabetes mellitus (DM) were
associated with culture positivity. In multivariate analyze only DM was
associated culture positivity (OR 5.63 [95% CI 1.99-15.91]
p=0,001). Conclusion DM increase possibility of blood culture
positivity. It stems from uncontrolled DM. Further studies are needed to
evaluate this condition stems from uncontrolled DM or both uncontrolled
and well-controlled DM.
Correlation Analysis and Text Classification of Chemical Accident Cases Based on Word Embedding
Authors: Jing Sifeng , Bi Rong , Liu Xiwei , Gong Xiaoyan , Tang Ying , Sun Xiaoyang
Published: March 2022

Word embedding and deep learning methods have shown to be very effective
in automated text information mining. In this work, a chemical accident
case analysis method is proposed and tested based on the methods.
Firstly, word vectors for the text corpus of chemical accident cases
were produced based on word2vec. And then Bidirectional LSTM model with
attention mechanism for text classification was constructed. Finally,
case studies on the correlation analysis of the common trends of
chemical accidents and automated text classification of chemical
accident cases documents were performed respectively. The results
revealed that the proposed method can identify common principles of
chemical accidents and classify chemical accident cases. These findings
highlight the feasibility of chemical accident case information mining
based on word embedding through case studies. Compared with rule-based
information mining, our method improves the efficiency, automation, and
intelligence of information mining from chemical accident cases
documents.
Genomic evidence reveals intraspecific divergence in the Hot-spring snake Thermophis baileyi, an endemic reptile of the Qinghai-Tibet Plateau
Authors: Yan Chaochao , Song Meng-Huan , Jiang Dechun , Ren Jin-Long , Lv Yunyun , Zaher Hussam , Li Jiatang
Published: March 2022

Understanding how and why species evolve often requires knowledge of
intraspecific divergence. In this study, we examine intraspecific
divergence in the endangered hot spring snake Thermophis baileyi, an
endemic species of the Qinghai-Tibet Plateau. Genomic analyses using a
hybrid assembly strategy resulted in a revised, high-quality genome.
Whole-genome re-sequencing of 31 sampled individuals from 15 sites
served to identify drivers of intraspecific divergence, and explore the
potential role gene selection plays in divergence. Our analyses resolved
three groups, with inter-group admixture occurring in regions of
contact. Divergence seems to have occurred during the Pleistocene
because of glacial climatic oscillations and geomorphological changes.
Highly diverged regions (HDRs) that distinguish the groups most likely
owe to gene sorting. Inter-group HDRs involve genes under positive
selection that putatively relate functionally to ecological divergence,
and especially reproduction. Our findings reveal the need to integrate
multiple aspects to distinguish evolutionary processes potentially
involved in speciation.
The effect of different pacing modes on LV global and regional longitudinal systolic strain by 2-D speckle tracking echocardiography
Authors: Yaseen Rehab , farid walaa , katta aza , soliman ahmed
Published: March 2022

Background Inspite of the fact that the life quality improved for most
patients with a cardiac pacemaker implant, the pacing induced left
bundle branch block pattern can result in changes of the structure,
function and hemodynamic of the heart. Methods: This study was performed
on 30 patients with history of dual chamber pacemaker implantation more
than 6 months duration and 30 healthy volunteers as controls.
Conventional and 2-D speckle tracking echocardiography were performed to
evaluate the LV global and regional systolic longitudinal strain in
different pacing modes. Results: Pacemaker programming from atrial
sensed-ventricular paced mode (AS-VP mode) to atrial paced-ventricular
paced mode (AP-VP) showed a significant decrease in global LV
longitudinal systolic strain (P value <0.05). Moreover,
programming to asynchronous ventricular pacing (VVI mode) demonstrated a
further significant reduction of global LV LSS when compared to other
pacing modes (P value <0.05). Conclusion: Permanent RV apical
pacing leads to marked changes of LV systolic function. Moreover, atrial
pacing and asynchronous ventricular pacing may cause more deterioration
of LV global and regional systolic longitudinal strain detected by 2-D
speckle tracking echocardiography.