Abstract PS13-02: Clinical Outcome and Patients’ Characteristics of Breast Cancer Diagnosed During Pregnancy: A Retrospective Single Institutional Study
Authors: Elshenawy Mahmoud A , Haque Emaan , Badran Ahmed , AlSayed Adhar , Twegieri Taher , Ajarim Dahish , Khayal Wafa , Malik Osama Al , Hefdhi Amal Al , Hassan Tusneem El , Akhtar Syed Saad , Zahrani Meshari Al , Aklabi Saba Al , Suleman Kausar 
Published: May 2024

Background:

Breast cancer (BC) is considered the second most common malignancy affecting pregnant women. Treatment of this condition is complex due to the potential risks it poses to both the fetus and mother. In this study, we report on the incidence, clinicopathological characteristics, management, and the outcomes of patients diagnosed with breast cancer during pregnancy in a tertiary care institution in Saudi Arabia.

Patients and methods:

This is a single-institution retrospective cohort analysis. We reviewed the medical records of all breast cancer cases in pregnant women that were diagnosed and treated at a a tertiary care center in Saudi Arabia, during the period from 2001 to 2017. We used Fisher’s exact test, chi-square, and Kaplan-Meier (KM) method for various analyses. Demographic data, treatment received, response, and prognostic factors were analyzed. The study was approved by the institutional review board at our center.

Results:

One hundred seventy-three patients met the search criteria. Median age at diagnosis was 34 (IQR: 30 – 38) years. Of these patients, 100 (58%) had invasive ductal carcinoma (IDC), 42 (24%) had IDC with ductal carcinoma in situ (DCIS), and 15 (20%) had other types. One hundred forty-two (82%) had pathological grades 2 and 3. Hormone receptors were positive in 90 (52%) patients, negative in 79 (45.7) patients and unknown in 4 (2.3%) patients. Her2/neu receptor status was positive in 67 (38.7%) patients and negative in 96(55.5%) patients. Forty five (26%) patients had triple negative disease.Stages I, II,III and IV were identified in 7(4%), 47 (27.2%), 54 (31.3%) and 51 (29.5%) patients respectively. Ninety (52%) and 75 (43%) patients received neoadjuvant and adjuvant anthracycline, platinum or taxane based chemotherapy. After being implemented in different international and our institutional guidelines, anti-Her2/neu therapies were given in 35 (20.2%) patients. The median overall survival (OS) was 127 months. Univariate analysis had shown statistically significant correlation between clinical stage, hormonal status, and overall survival.

Conclusion:

Breast cancer diagnosed during pregnancy is associated with poor outcomes. Breast cancer awareness and screening programs are essential for early detection and proper management thereby leading to better outcomes.

Citation Format: Mahmoud A Elshenawy, Emaan Haque, Ahmed Badran, Adhar AlSayed, Taher Twegieri, Dahish Ajarim, Wafa Khayal, Osama Al Malik, Amal Al Hefdhi, Tusneem El Hassan, Syed Saad Akhtar, Meshari Al Zahrani, Saba Al Aklabi, Kausar Suleman. Clinical Outcome and Patients’ Characteristics of Breast Cancer Diagnosed During Pregnancy: A Retrospective Single Institutional Study [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PS13-02.