bluuebunny/crossref_metadata_2025 huggingface dataset:
Análise do tempo e dimensão epistemológica do saber: limite de uma função real
Authors: Figueroa Teodora Pinheiro , Almouloud Saddo Ag
Published: February 2019

Este artigo apresenta o resultado de parte de uma pesquisa de pós-doutorado que se refere a construção de uma linha do tempo a respeito das primeiras ideias do objeto matemático Limites de Funções de uma Variável Real, do século V a.C. com os paradoxos de Zenão até o século XIX d.C. com Louis-Augustin Cauchy (1789-1857) e Karl Weierstrass (1815-1897), cujo período envolve um estágio inicial, intermediário e formal do conceito. A partir destes relatos, o objetivo específico é construir um mapa epistemológico deste saber, englobando aspectos históricos e filosóficos, a fim de responder algumas questões referentes a dimensão epistemológica: Qual a gênese do saber? Quais os conhecimentos envolvidos na construção deste saber? Acredita-se que as respostas a essas questões serão de fundamental importância tanto para o pesquisador em didática da matemática, como para o professor de matemática.
Natureza da ciência: o que os pesquisadores brasileiros discutem?
Authors: Krupczak Carla , Aires Joanez Aparecida
Published: February 2019

No ensino de Ciências é consenso que um tópico importante deste é a abordagem sobre a Natureza da Ciência (NdC), esta visa discutir sobre a construção do conhecimento científico, desmistificando estereótipos sobre a Ciência e o trabalho do cientista. Considera-se que um melhor entendimento sobre o desenvolvimento científico e tecnológico pode contribuir para a formação de cidadãos que tomam decisões mais fundamentadas sobre Ciência e Tecnologia. Tendo em vista a relevância do tema, estudos sobre NdC vêm aumentando, gerando trabalhos que analisam as tendências dessa temática em artigos, todavia, há carência de trabalhos que se debrucem sobre as teses e dissertações brasileiras. Nesse sentido, o objetivo desta pesquisa é mapear como estão distribuídos esses estudos sobre NdC no Brasil, bem como analisar as tendências destes, em relação aos objetivos das pesquisas. A investigação é do tipo estado do conhecimento, de natureza quantiqualitativa. A constituição dos dados foi realizada no Banco de Teses e Dissertações da CAPES e as análises se deram usando a Análise de Conteúdo. Foram encontrados 233 trabalhos, com maior produtividade a partir de 2008. As pesquisas concentram-se na região sudeste do país, em instituições públicas e os temas mais estudados foram estratégias didáticas e concepções sobre NdC.
Tradução de 5 Poemas de John Wieners
Authors: De Carvalho Age
Published: February 2019

Tradução de 5 poemas do poeta americano John Wieners, realizada por Age de Carvalho
Age de Carvalho e Benedito Nunes: um poeta e um crítico
Authors: Do Nascimento Maria de Fátima
Published: February 2019

O artigo examina a relação entre Benedito Nunes (1929-2011) e Age de Carvalho (1958-), respectivamente crítico e poeta paraenses. Em 1980, o poeta participa de um concurso de poesias e também o crítico avalia o certame. Age de Carvalho, um dos premiados, ganha a publicação de seu primeiro livro, Arquitetura dos ossos (1980). Constata-se então que Benedito Nunes passa a ser um leitor especializado de Age de Carvalho, cuja obra de estreia tem orelha escrita pelo crítico brasileiro. Os dois intelectuais mantêm contatos sobre arte poética e Benedito Nunes publica ainda, a respeito de Age de Carvalho, apresentações, orelhas e posfácios, como “Jogo marcado”, para A fala entre parêntesis (1982), livro produzido por seu autor e outro poeta paraense, Max Martins, além de fazer em alemão, para a obra Sangue-Gesang (2006), posfácio republicado em português em Do Marajó ao arquivo: breve panorama da cultura do Pará (2012), de Benedito Nunes.
Antevéspera, noite interior atravessar uma canção que me atravessa
Authors: Ribeiro Gustavo Silveira
Published: February 2019

leitura do poema “Segues a tua estrela”, de Age de Carvalho, ainda inédito, sob a perspectiva do desejo e da transformação do corpo feminino, desdobrando os motivos da criação e do nascimento, do sagrado e do cotidiano, destacando os expedientes poéticos usados na composição do poema: fragmentação de palavras, contrastes, elipses, colagens de fragmentos.
Viagem, poesia e morte em Age de Carvalho
Authors: Guimaraes Mayara Ribeiro
Published: February 2019

Análise dos poemas “Atravessando” e “Ele, o rico-de-sombras”, de Age de Carvalho (Ainda: em viagem, 2015), sob a perspectiva do topos da viagem como experiência-limite ligada à morte e à natureza da linguagem poética. A partir da reflexão em torno da figura de Odisseu enquanto signo literário que surge na Odisseia, de Homero, e se abre aos sistemas de signos que cada período literário lhe conferirá, pela perspectiva do crítico italiano Piero Boitani, busca-se discutir a trágica verdade que acompanha a poesia: a de que conhecer é perecer, e que o fenômeno poético se manifesta como ponto frágil entre duas margens.
Age de Carvalho: ex- sub, solitário
Authors: Ávila Myriam
Published: February 2019

Pela imagem do poeta solitário, este ensaio explora a presença da solidão e seu intercâmbio com a experiência de exílio, em poemas de Age de Carvalho que percorrem diferentes fases de sua poética. Dentre eles “No hotel”, “De viagem”, “48, no aeroporto”. O texto recupera ainda o diálogo de sua poesia com a de Max Martins e Mário Faustino.
Decomposição e degeneração em Arquitetura dos ossos. Cintilações do corpo sem órgãos em Age de Carvalho.
Authors: Sarmento-Pantoja Tânia
Published: February 2019

Análise de poemas do livro Arquitetura dos ossos (1980), de Age de Carvalho, a partir das noções de tempo, e sua relação com a tradição, e corpo, em seus aspectos decompositivo e degenerativo, como elementos fundantes de sua poesia. Busca-se ler a maneira corrosiva como sua poesia trata das fragilidades do ser e sua condição perecível e material. O ensaio pensa a categoria de corpo sem órgãos como lugar de resistência contra as formas de ordenação, sob a ótica de Gilles Deleuze e Felix Guattari em intertxto com Antonin Artaud, e no intercâmbio com a cidade, a memória e a experiência de morte.
A nacionalidade como problema historiográfico: primeiros momentos da história literária brasileira
Authors: Matte Gustavo Arthur
Published: February 2019

Pensando a História enquanto prática social, reflito sobre como a busca por assertividade identitária no pós-independência pode revelar os projetos intelectuais/ideológicos que orientaram a formação do Estado Nacional brasileiro. A elite intelectual do século XIX iniciou um projeto em busca da cultura brasileira “original” (tanto de “origens” quanto de “originalidade”), mas a ausência da participação de grupos minoritários aponta para o caráter excludente do projeto que estava em curso. Foi se estabelecendo um paradigma da nação através das camadas privilegiadas e confundidas com as próprias instituições. Também, é através desse perfil bastante específico do sujeito enunciador que se constrói o perfil de um sujeito da nação (o cidadão). Através, então, da leitura de textos fundadores da história literária brasileira sob a ótica de reflexões recentes sobre memória nacional (ACHUGAR), cultura brasileira (FINAZZI-AGRÒ e ORTIZ) e representatividade cultural (DALCASTAGNÈ), pretendo fornecer algumas pistas para a seguinte questão: quem foi (e quem é), afinal, o “sujeito do discurso nacional”, que realiza a escrita da história e a construção da memória?
The effect of VR and traditional videos on learner retention and decision making
Authors: Yıldırım Gürkan , Yıldırım Serkan , Dolgunsoz Emrah
Published: February 2019

Virtual reality (VR) as computer-mediated 3-D environments including real-life situations presented via different tools in which users can interact effectively with visuals. This study is significant as it primarily aimed to investigate effects of VR on retention by comparing it with traditional 2-D videos. The main aim of this study is to compare the effect of VR and 2-D videos on learner retention and decision making. About 18 students from the Department of English language teaching in an age range of 18–20 (nine males and nine females) voluntarily participated in this study and took course credits. As all participants were tested under the same two conditions in different time periods; repeated measures were chosen for statistical analysis. It can be inferred that both technologies have similar effects on short-term retention and VR does not provide any extra retention performance. However, VR was found to have a significant effect on long-term retention.
STATUS HEMOGLOBIN, KEBIASAAN MEROKOK DAN DAYA TAHAN KARDIORESPIRASI (VO2 MAX) PADA ATLET UNIT KEGIATAN MAHASISWA BOLA BASKET
 [Haemoglobin Status, Smoking Habits and Cardiorespiratory Endurance (Vo2 max) among Basketball Student Activity Units]
Authors: Anggraeni Lidya , Wirjatmadi R. Bambang
Published: February 2019

Basketball athlete require maximum oxygen capacity to maintain their endurance during physical activity for long time. Good cardio respiratory endurance for athlete can slower fatigue so they can reach a peak performance optimally. Many factors affect cardio respiratory endurance such as haemoglobin status and smoking habits. The purpose of this study was to analyze the correlations between haemoglobin status and smoking habits with cardio respiratory endurance among basketball student activity unit. This research was an observational analytic with case control study design. The sample in this research were 50 people and divided into case (25 people) and control (25 people) groups. Data collections included cooper test, blood sampling with cyanmethemoglobin method and smoking habits. The result showed that there were correlation between haemoglobin status p=0.014 (OR = 6.78; 95% CI: 1.6-28.54), smoking habits p=0.020 (OR = 7.67; 95% CI: 1.47-39.98) with cardio respiratory endurance. Non anemia and non-smoking Athletes have a better cardio respiratory endurance than anemia and smoking athletes. It is recommend to maintain haemoglobin status in the normal range to avoids anemia and quit smoking to increase their optimal cardio respiratory endurance
RASA, PENAMPILAN, DAN SISA SAYURAN PASIEN ANAK DI RUMKITAL DR. RAMELAN SURABAYA
[Vegetables Taste, Appearance, and Waste in Pediatric Patients at Dr. Ramelan Naval Hospital Surabaya]
Authors: Armadita Padella Dian Julia , Primadona Suzanna , Mahmudiono Trias
Published: February 2019

Food waste should get the attention because it will contribute to recovery time during illness as fulfilling the energy and nutrients need. Meanwhile, many hospitals are having leftover food more than 20 percent. Internal and external factor have correlation with it. This study aimed to analyze the relation between vegetables taste, appearance and waste vegetables among pediatric patients in Dr Ramelan Naval Hospital, Surabaya. This research was a cross sectional study. The samples were 32 children aged 2-12 years old whom hospitalized in class II and III patient rooms. The primary data was collected by interview and observation. Vegetables waste measured by Comstock form. Chi square test was used to analyze the relation between the taste, appearance and waste of vegetables. The result showed that there was no correlation between vegetables waste with four aspects of taste and five aspect of appearance (p value>0.05). Nonetheless, taste, consistency, platting method, and portion tend to have a big difference on vegetables waste.
HUBUNGAN KECENDERUNGAN DEPRESI DENGAN STATUS GIZI PADA LANSIA DI UPTD GRIYA WERDHA SURABAYA
[Correlation of Depression Tendency and Nutritional Status of Elderly in UPTD Griya Werdha Surabaya]
Authors: Putri Hasna Rosida , Nindya Triska Susila
Published: February 2019

Malnutrition is one of the causes of health problems in the elderly. Nutritional status of the elderly can be affected by many factors, such as food intake, comorbidities, drugs consumption, physical activity, and depression. Depression status has a relationship with the nutritional status of the elderly by influencing the intake of the elderly. The purpose of this study was analyze the correlation and the risk of depression tendency with elderly nutritional status at UPTD Griya Werdha Surabaya. This study was a case-control design. The number of respondents were 30 elderly consist of 15 elderly in each case and control groups. The case group was elderly who had MNA score <24 points, while the control group was elderly who had MNA score of ≥24 points. Depression were measured by Short Geriatric Depression Scale (GDS). Spearman correlation test was used to analyze the data. Most of the elderly do not experience depression (GDS<5). There was a correlation between depression with nutritional status of the elderly (p=0.007). Depression elderly were 9.75 times more likely to malnourished than nutritional status [OR=9.75, 95% CI =`1.63 (1.45-1.81)]. Nutritional status was correlated with the tendency of depression in the elderly. It is necessary to increase more activities at the UPTD Griya Werdha Surabaya to reduce the risk of depression among elderly.
BODY IMAGE, TINGKAT KECUKUPAN ZAT GIZI, DAN FAD DIETS PADA MODEL REMAJA PUTRI DI SURABAYA
[Body Image, Nutritional Adequacy Level, and Fad Diets among Female Adolescent Models in Surabaya]
Authors: Jannah Imas Nur , Muniroh Lailatul
Published: February 2019

Female adolescent models are required to look attractive which could trigger a negative body image and rapid weight loss by involving fad diets. This study was aimed to analyze the relationship between body image and nutritional adequacy level with fad diets among female adolescent models in Surabaya. This study was a cross sectional on 60 female adolescent models aged 14-20 who were selected by accidental sampling technique. Nutritional adequacy level was assesed using food recall 2x24 hours, body image and fad diets were evaluated using modified Body Shape Questionnaire (BSQ-16a) and fad diets questionnaire. Data were analyzed by chi square test. The results showed that most female adolescent models had negative body image (58.3%); energy adequacy level (80.0%), carbohydrate (86.7%), protein (56.7%), and fat (56.7%) were categorized deficient; doing fad diets (70,0%). There were moderate correlation between body image and fad diets (r=0.484) and there was a weak correlation between energy adequacy level (r=0.054), carbohydrate (r=0.188), protein (r=0.090), and fat (r=0.232) with fad diets. It was concluded female adolescent models who had a negative body image tend to do fad diets. Female adolescent models are expected to have a healthy diet and balanced nutrition, also consult to nutritionist in order to achieve an ideal body weight.
Michael Reese Hospital and the Campaign to Warn the US Public of the Long-Term Health Effects of Ionizing Radiation, 1973–1977
Authors: Bavli Itai , Shvarts Shifra
Published: February 2019

In July 1973, a study at the University of Chicago linked radiation treatment during childhood to a variety of diseases, including thyroid cancer. A few months later, a worker at Michael Reese Hospital in Chicago, Illinois found a registry of 5266 former patients who had been treated with radiation during the 1950s and 1960s. Hospital officials decided to contact these patients and arrange for follow-up medical examinations. Media coverage of the hospital’s campaign had a snowball effect that prompted more medical institutions to follow suit, resulting in the National Cancer Institute (NCI) launching a nationwide campaign to warn the public and medical community about the late health effects of ionizing radiation. This study describes how the single action of a hospital in Chicago and the media attention it attracted led to a national campaign to warn those who underwent radiation treatment during childhood.
Логические идеи Феодора Продрома: «О великом и малом»
Authors: Гончарко О. Ю. , Слинин Я. А. , Черноглазов Д. А.
Published: February 2019

В данной статье второй в историко-философском цикле статей о логических трудах Феодора Продрома, византийского автора XII века, рассматривается трактат Феодора Продрома «О великом и малом», адресованный Михаилу Италику и написанный в лучших традициях неоплатонического комментария к «Категориям» Аристотеля. Цель статьи познакомить современного читателя с логическими идеями Феодора Продрома, а также оценить оригинальность его комментария. Этот небольшой трактат посвящен вопросу отнесения понятий «великого» и «малого», а также «многого» и «немногого» к какой-либо из десяти категорий Аристотеля. Однако аристотелевское решение не устраивает Феодора Продрома по той причине, что Аристотель не относит эти понятия к какой-то отдельной категории, но допускает возможность их отнесения к разным категориям (количества и отношения) с разных точек зрения. В статье приводится ряд аргументов Феодора Продрома, с помощью которых он пытается показать, что понятия «великого» и «малого» не относятся к категории отношения. Аргументация Феодора Продрома довольно подробна и разнообразна: он приводит контрпримеры аристотелевским рассуждениям, критикует сами критерии отнесения понятий к категориям, анализирует практику словоупотребления понятий и их сравнительных степеней, практику использования падежей в греческом языке, порядок категорий, выстраивает вполне оригинальную последовательность аргументов против аристотелевского решения, изящно прибегая к тексту самого Аристотеля. Однако, как мы попытались показать в статье, этот небольшой текст Феодора Продрома близок по содержанию к некоторым фрагментам «Комментария к “Категориям”» Порфирия, в которых также затрагивается проблема отнесения понятий «великого» и «малого» к той или иной категории. Несмотря на то, что Феодор Продром приходит к несколько другим выводам, чем Порфирий, использование фрагментов его текста очевидно, и даже складывается впечатление, что Феодор Продром спорит скорее с Порфирием, чем с Аристотелем. DOI: 10.21146/2074-1472-2018-24-2-11-35
Бесконечнозначная логика Лукасевича и ряды Фарея
Authors: Преловский Н. Н.
Published: February 2019

В статье будет рассказано о связи между критерием Мак-Нотона для бесконечнозначной логики Лукасевича, простыми числами и рядами Фарея. Дано определение простого числа в терминах бесконечнозначной логики Лукасевича. В соответствии с критерием Мак-Нотона, множество функций бесконечнозначной логики Лукасевича совпадает с множеством непрерывных кусочно-линейных функций особого вида. В докладе показано, что простота числа $n$ зависит от существования таких функций бесконечнозначной логики Лукасевича, что ограничение каждой из них на соответствующую конечнозначную логику Лукасевича совпадает со значением функций $N_{1/n}(x)$. При этом каждая такая функция имеет кусочно-линейные эквиваленты, линейные коэффициенты которых могут быть найдены с помощью подходящих рядов Фарея. А именно, возникает возможность охарактеризовать все линейные функции, проходящие через точку с координатами $(\frac{i}{n},\frac{1}{n})$. Действительно, все такие функции описываются уравнениями вида $f(x)=b+kx$ с целыми коэффициентами $b$ и $k$, что $\frac{1}{n}=b+k\frac{i}{n}$, что позволяет отыскать данные коэффициенты в подходящих рядах Фарея. DOI: 10.21146/2074-1472-2018-24-2-123-128
«Онтологический квадрат» и теоретико-типовая семантика
Authors: Долгоруков В. В. , Копылова А. О.
Published: February 2019

Настоящая статья посвящена конкретному эпизоду в большой дискуссии о соотношении семантики и онтологии: а именно, поиску адекватной семантической интерпретации для набора сущностей, постулируемых так называемым «онтологическим квадратом» или «четырех-категорными онтологиями».

Онтологическим квадратом называется теория, восходящая к работам Аристотеля (в частности, ко второй главе трактата «Категории») и утверждающая необходимость различения между четырьмя типами сущностей: субстанциальными универсалиями, субстанциальными партикуляриями, акцидентальными универсалиями, акцидентальными партикуляриями.

В программной статье «Против Фантологии» Б. Смит пытается продемонстрировать, что онтологический квадрат не может быть адекватно описан в рамках логики предикатов. Б. Смит упрекает Г. Фреге в том, что тот, будучи отцом современной логики, стал одновременно и отцом «фантологии», теории, в рамках которой все разнообразие сущностей сводится к объектам («$a$») и предикатам(«$F$»).

Избавление логики от «фантологии», с точки зрения Б. Смита, возможно благодаря обогащению логики предикатов целым набором отношений, которые соответствуют допущениям «онтологического квадрата» и тем самым обогащают постулируемую логическими теориями систему онтологических допущений. С нашей точки зрения, подход Б. Смита обладает рядом недостатков: формулируемая им теория рассматривает в качестве универсалий только предикаты разного типа. То есть, богатая система отношений, которая предлагается в рассматриваемом подходе, не лишена «фантологических» черт: все рассматриваемые Б. Смитом отношения на уровне метаязыка соответствуют множеству кортежей.

В настоящей статье мы предлагаем другой вариант формализации сущностей, постулируемых «онтологическим квадратом» вариант, который базируется на теоретико-типовой семантике и обладает рядом преимуществ перед подходом Б. Смита.

Мы оставляем за скобками вопрос об истинности или адекватности «онтологического квадрата» в качестве метафизической теории. Наш тезис носит более слабый характер: мы постарались продемонстрировать, что теоретико-типовая семантика может рассматриваться как релевантный инструмент для формализации сущностей, которые различаются в «онтологическом квадрате». DOI: 10.21146/2074-1472-2018-24-2-36-58
Model checking for coalition announcement logic
Authors: Алешина Н.А.
Published: February 2019

This talk is based on joint work with Rustam Galimullin and Hans van Ditmarsh, published in the German Conference on Artificial Intelligence (KI 2018). First I will introduce background and motivation for the work. I will introduce multi-agent Epistemic Logic (EL) for representing knowledge of (idealised) agents, Public Announcement Logic (PAL) for modelling knowledge change after truthful announcements, Group Announcement Logic (GAL) for modelling what kinds of changes in other agents’ knowledge a group of agents can effect, and Coalition Announcement Logic (CAL) which is the main subject of the talk. CAL studies how a group of agents can enforce a certain outcome by making a joint announcement, regardless of any announcements made simultaneously by the opponents. The logic is useful to model imperfect information games with simultaneous moves. It is also useful for devising protocols of announcements that will increase some knowledge of some agents, but also preserve other agents’ ignorance with respect to some information (in other words, preserve privacy of the announcers). The main new technical result in the talk is a model checking algorithm for CAL, that is, an algorithm for evaluating a CAL formula in a given finite model. The model-checking problem for CAL is PSPACE-complete, and the protocol requires polynomial space (but exponential time). DOI: 10.21146/2074-1472-2018-24-2-59-69
Wormhole Formation During Acidizing of Calcite-Cemented Fractures in Gas-Bearing Shales
Authors: Szymczak Piotr , Kwiatkowski Kamil , Jarosinskí Marek , Kwiatkowski Tomasz , Osselin Florian
Published: February 2019

A relatively large number of calcite-cemented fractures are present in gas-bearing shale formations. During hydraulic fracturing, some of these fractures will be reactivated and may become important flow paths in the resulting stimulated fracture network. On the other hand, the presence of carbonate lamina on fracture surfaces will have a hindering effect on the transport of shale gas from the matrix toward the wellbore. We investigate numerically the effect of low-pH reactive fluids on such fractures, and show that dissolution of the cement proceeds in a highly nonuniform manner. The morphology of the emerging flow paths (“wormholes”) strongly depends on the thickness of the calcite layer. For thick carbonate layers, a hierarchical, fractal pattern appears, with highly branched wormhole-like channels competing for an available flow. For thin layers, the pattern is much more diffuse, with less-pronounced wormholes that merge easily with each other. Finally, for intermediate thicknesses, we observe a strong attraction between shorter and longer wormholes, which leads to the formation of islands of carbonate lamina surrounded by the dissolved regions. We argue that the wormhole-formation processes are not only important for the increase of shale-gas recovery, but also can be used for retaining the fracture permeability, even in the absence of proppant.
Anesthetic management of gigantic pheochromocytoma resection with inferior vena cava and right atrium tumor thrombosis: A case report
Authors: Chen Jingli , Liu Caihua , Liu Chang , Fu Quanyuan , Peng Dingwei , Ren Linyun , Yan Hong
Published: February 2019

Background: This report describes one case of anesthetic management about surgical resection of a malignant phaeochromocytoma with tumor extension into vena cava and right atrium in a patient. Report for anesthetic management is limited in these patients under surgical resection until now.
Case presentation: In September 2015, a 24-year-old male presented to the department of cardiology with right flank pain and hypertensive urgency in our hospital. Contrast-enhanced CT abdomen and MRI abdomen revealed right adrenal mass suspicious of malignancy with invasion and compression to the right IVC wall along with IVC thrombus extending from the level of renal veins to the level of confluence with hepatic veins. Echocardiography shown no abnormal detection. Finally, this patient gave up the surgical resection of phaeochromocytoma and chose the expectant treatment. In April 2018, this patient once again presented to the emergence department with a persistent cough and intermittent wheezing character for 5 hour. Contrast-enhanced CT and echocardiography shown existing IVC thrombus had extended into the right atrium. After the careful preoperative preparation, adrenalectomy with complete thrombus excision by inferior vena cava exploration and right atriotomy were performed successfully by a multidisciplinary team. After one month post-operation care, the patient healthily leave our hospital.
Conclusion: To the best of our knowledge, the occurrence of pheochromocytoma in IVC and right atrium thrombosis has not been reported so far from mainland China. This clinical case may supply a rare reference experience for surgical treatment and anesthetic management in the group of phaeochromocytoma patient with distance vascular extension.
Keywords: Adrenal tumor; Malignant phaeochromocytoma; Inferior vena cava; Right atrium; Tumor thrombus.
Neurogenic pulmonary edema after subarachnoid hemorrhage: a case report
Authors: Chen Xiaoxiang , Chen Maohua , Lu Chuan , Sun Jun , Ba Huajun
Published: February 2019

Background: Neurogenic pulmonary edema is a relatively rare and severe complication of acute central neurologic injury, particularly aneurysmal subarachnoid hemorrhage. It has been rather neglected and even misdiagnosed in clinical practice due to its non-specific manifestation.
Case presentation: We describe a 44‑year‑old woman suffering from the life-threatening pulmonary edema with a aneurysmal subarachnoid hemorrhage. She was successfully treated with positive end-expiratory pressure and coil embolization at acute stage. The patient was discharged without neurological deficits.
Conclusions: Early endovascular intervention and proper timely management of neurogenic pulmonary edema is critical for improving
outcomes after aneurysmal subarachnoid hemorrhage.
Keywords: Neurogenic pulmonary edema, subarachnoid hemorrhage, aneurysmal rupture.
THE DESIGN OF EXPERT SYSTEM FOR DETERMINING THE INITIAL DIAGNOSIS OF TROPICAL INFECTIOUS DISEASES IN INDONESIA WITH NAIVE BAYES METHOD-BASED ANDROID
Authors: Permana Andrew Dwi , Suyadnya I Made Arsa , Khrisne Duman Care
Published: February 2019

Tropical infectious diseases are frequent, serious and concerning for the people in Indonesia. Tropical infectious diseases can be fatal and cause death. But if we diagnose them earlier and get proper treatment, the story can be changed. In this research will make a mobile application using Naive Bayes and Forward Chaining methods for early diagnosing tropical infectious diseases including typhoid fever, dengue fever, tuberculosis, malaria, and measles. The process of this application will start with input of the symptoms felt by users, after the data collected, system will calculate the data with Naive Bayes formula. This application using 147 data training from interviewed with the experts. Based on the tests by System Usability Scale method shows above average users rating 73.875 %, which means the results of the application are acceptable. And Confusion Matrix method shows performance of the application as high as 76.74 %.
Coexistence of valence-bond formation and topological order in the Frustrated Ferromagnetic $J_1$-$J_2$ Chain
Authors: Agrapidis Cliò Efthimia , Drechsler Stefan-Ludwig , van den Brink Jeroen , Nishimoto Satoshi
Published: February 2019

Frustrated one-dimensional (1D) magnets are known as ideal
playgrounds for new exotic quantum phenomena to emerge. We consider an
elementary frustrated 1D system: the spin-\frac{1}{2}12
ferromagnetic (J_1J1)
Heisenberg chain with next-nearest-neighbor antiferromagnetic
(J_2J2)
interactions. On the basis of density-matrix renormalization group
calculations we show the existence of a finite spin gap at
J_2/|J_1|>1/4J2/|J1|>1/4
and we find the ground state in this region to be a valence bond solid
(VBS) with spin-singlet dimerization between third-neighbor sites. The
VBS is the consequence of spontaneous symmetry breaking through order by
disorder. Quite interestingly, this VBS state has a
Affleck-Kennedy-Lieb-Tasaki-type topological order. This is the first
example of a frustrated spin chain in which quantum fluctuations induce
gapped topological order.
Corporate governance and risk taking of Jordanian listed corporations: the impact of board of directors
Authors: O. Al-Smadi Mohammad
Published: February 2019

The aim of this study is to evaluate the compliance level of corporate governance rules and examine the impact of this compliance on risk taking of corporations in Jordan. This study used panel data of the listed corporations in Amman Stock Exchange from 2013 to 2017. Corporate governance index was constructed to gauge the compliance level of corporate governance rules. The results show a good level of overall compliance of corporate governance rules. As for the compliance of the categories of corporate governance rules, rules of transparency and disclosure are ranked first, while rules of general meeting assembly are ranked fourth. The regression results report a negative influence of corporate governance and corporate risk taking. In addition, four governance variables concerning the features of the board of directors are used in the study. The results reveal a negative impact of the size of the board of directors, independence of the board, and committees of the board on corporate risk taking. It is expected that the outcomes of the study can be used by management of the corporations in addition to the Jordanian Securities Commission that seek to enhance confidence in the Jordanian capital market.
A AUSÊNCIA DE QUALIDADE DO ENSINO E A CONSEQUENTE OFENSA AOS DIREITOS DA CRIANÇA E DO ADOLESCENTE EM FACE DO FRACASSO ESCOLAR
Authors: Costa Fabricio Veiga , Da Motta Ivan Dias , Dante Caroline Rodrigues Celloto
Published: February 2019

O objetivo da pesquisa consistiu em demonstrar que a educação tem previsão constitucional, sendo um direito fundamental, público subjetivo e da personalidade, ressaltando-se a importância de uma oferta com qualidade. Na problemática proposta, enfatizou-se o fracasso escolar, que consiste em não ofertar da educação com qualidade, no caso da educação básica. A metodologia empregada consistiu na pesquisa bibliográfica e documental acerca do tema, visando o estado da arte, utilizando-se em especial o método dedutivo. Embora haja previsão constitucional e legal sobre o direito à educação, assegurando-se, inclusive, o padrão de qualidade no ensino ofertado, referida realidade não abrange todas as crianças e adolescentes, ocorrendo o fracasso escolar. Impõe-se uma atuação efetiva por parte do Estado, com a participação da família e da sociedade para o aludido cenário, visando o pleno desenvolvimento por intermédio da educação.
CENTRALISMO, CORRUPÇÃO E CULTURA DO JEITO NA REPÚBLICA FEDERATIVA DO BRASIL
Authors: Cimadon Aristides
Published: February 2019

O presente artigo discorre sobre o aviltamento dos princípios do federalismo, cuja maioria de competências do Estado se centraliza na União. Apresenta argumentos a respeito da ilusão da Democracia, da participação popular e alerta para a formação de uma consciência forjada pelos meios de comunicação e pela retórica de marketing. Por fim, procura demonstrar que o federalismo brasileiro não cumpre o princípio da autonomia de competência do Estado Federado. Apresenta argumentos sobre a ilusão da Democracia, da participação popular e alerta para a formação de uma consciência manipulada pelos meios de comunicação e pela retórica de marketing. Enfim, procura demonstrar que o federalismo brasileiro não cumpre o princípio de autonomia de competência do Estado Federado.
ON SOCIOLOGY: NUMBERS, NARRATIVES, AND THE INTEGRATION OF RESEARCH AND THEORY
Authors: Asensi Felipe Dutra
Published: February 2019

On Sociology busca promover uma reflexão que unifique ou, ao menos, aproxime a relação entre teoria e pesquisa. A estratégia de Goldthorpe consiste em combinar a pesquisa quantitativa em larga escala (large-scale) e o poder explicativo da teoria da ação social. Nesta resenha, o objeto de discussão será o primeiro volume de On Sociology, com um enfoque menos expressivo na terceira parte do livro. O autor desdobra o livro em quatro partes. A primeira parte estabelece críticas a algumas abordagens sociológicas. A segunda parte do livro diz respeito ao programa de pesquisa de Goldthorpe, que combina a análise quantitativa à teoria da ação racional. Na terceira parte, Goldthorpe busca ilustrar seu programa através de exemplos concretos de sua aplicação no que concerne à estratificação social. Na última parte do livro, Goldthorpe realiza um breve exame histórico e intelectual sobre o motivo pelo qual o pensamento probabilístico, o método estatístico e o individualismo metodológico não obtiveram amplo sucesso na sociologia americana e européia. De fato, Goldthorpe busca constituir uma abordagem teórica que articule o “micro” e o “macro”, relacionando a análise quantitativa e a teoria da ação racional. Conclui-se que o autor busca introduzir uma microteoria no interior das reflexões estatísticas. De fato, a associação entre análise quantitativa e ação racional pode ser útil, mas apresenta limitações. Todavia, trata-se de uma obra exemplar pela sua originalidade e pela sua ampla articulação entre teoria e prática.
A RESPONSABILIDADE DO PROFISSIONAL NA DEFESA DO MEIO AMBIENTE
Authors: Iasbik Thaís Aldred , Gomes Magno Federici
Published: February 2019

A Política Nacional do Meio Ambiente (PNMA) estabelece, dentre outros instrumentos, a Avaliação de Impactos Ambientais (AIA) e o Cadastro Técnico Federal de Atividades e Instrumentos de Defesa Ambiental (CTF/AIDA) voltados para a promoção do desenvolvimento sustentável. A investigação pretendida neste artigo avalia os níveis da responsabilização administrativa dos profissionais envolvidos nessas atividades, questionando sua extensão, para apontar a incidência de penalidades administrativo-ambientais, além do regime ético disciplinar estabelecido pelos respectivos conselhos de classe. O método utilizado foi o jurídico propositivo além do hipotético dedutivo.
Os DIREITOS HUMANOS E O ACESSO À JUSTIÇA: UMA ANÁLISE HISTÓRICO-CONCEITUAL DE UM DIREITO FUNDAMENTAL PARA A CONVIVÊNCIA HUMANA PACÍFICA
Authors: Bedin Gilmar Antonio , Schonardie Elenise Felzke
Published: February 2019

O presente artigo busca contextualizar a temática do direito de acesso à justiça sob a ótica dos direitos humanos. A análise inicia-se pela trajetória histórica de evolução dos direitos humanos nas sociedades ocidentais e sua apresentação em gerações. Na sequência, demonstra-se a significativa expansão do direito de acesso à justiça no mundo moderno, sua importância e preocupação no âmbito legislativo nacional e internacional. Por fim, conclui que o direito de acesso à justiça é uma forma de mediação democrática dos conflitos e constitui-se num instrumento de pacificação social e de educação para a convivência humana pacífica e voltada ao fortalecimento do Estado de Direito e ao respeito à dignidade humana.
Mass Spectrometry for Proteomics and Recent Developments in ESI, MALDI and other Ionization Methodologies
Authors: Farooq Qurat ul Ain , Haq Noor ul , Aziz Abdul , Aimen Sara , Inam ul Haq Muhammad
Published: February 2019

Background:

Mass spectrometry is a tool used in analytical chemistry to identify components
in a chemical compound and it is of tremendous importance in the field of biology for high
throughput analysis of biomolecules, among which protein is of great interest.

Objective:

Advancement in proteomics based on mass spectrometry has led the way to quantify multiple
protein complexes, and proteins interactions with DNA/RNA or other chemical compounds which
is a breakthrough in the field of bioinformatics.

Methods:

Many new technologies have been introduced in electrospray ionization (ESI) and Matrixassisted
Laser Desorption/Ionization (MALDI) techniques which have enhanced sensitivity, resolution
and many other key features for the characterization of proteins.

Results:

The advent of ambient mass spectrometry and its different versions like Desorption Electrospray
Ionization (DESI), DART and ELDI has brought a huge revolution in proteomics research.
Different imaging techniques are also introduced in MS to map proteins and other significant biomolecules.
These drastic developments have paved the way to analyze large proteins of >200kDa easily.

Conclusion:

Here, we discuss the recent advancement in mass spectrometry, which is of great importance
and it could lead us to further deep analysis of the molecules from different perspectives and
further advancement in these techniques will enable us to find better ways for prediction of molecules
and their behavioral properties.
Proteomics Study of Mesenchymal Stem Cell-Like Cells Isolated from Cerebrospinal Fluid of Patients with Meningioma
Authors: Saffarian Arash , Tarokh Amir , Reza Haghshenas Mohammad , Taghipour Mousa , Chenari Nooshafarin , Ghaderi Abbas , Razmkhah Mahboobeh
Published: February 2019

Background:

Cerebrospinal fluid (CSF) contains pro-growth factors that can affect proliferation, migration and differentiation of Mesenchymal Stem Cells (MSCs).

Objective:

This study aimed to isolate MSC like cells from CSF of patients with meningioma and psudotumorcerebri (PTC) and identify differentially expressed proteins in these cells.

Methods:

Five patients with newly diagnosed intracranial meningioma and five patients with PTC were recruited in this comparative proteomics study. MSCs were isolated from CSF and validated by mesenchyml and non-mesenchyml fluorochrome antibodies, and flow cytometer analysis. Two- Dimensional Gel Electrophoresis (2-DE) coupled with Mass Spectrometry (MS) was performed to identify differentially expressed proteins.

Results:

Microscopic views of the isolated cells as well as flow cytometer analysis were found to be compatible with MSC-like cells. Eight distinct protein spots were differentially and reproducibly expressed among the stained gels of two studied groups. The identified proteins were Phosphoglycerate Mutase 1 (PGAM1), LIM and SH3 domain protein (LASP1), peroxiredoxin-6 (PRDX-6), type I cytoskeletal 9 (KRT9), Superoxide Dismutase (SOD), endoplasmin, Stathmin 1 (STMN1), and glutathione S-transferase (GST).

Conclusion:

This study provides new insights into the plausible role of CSF derived MSCs in cancer progression, and reveals a promising therapeutic opportunity for targeting of MSC proteins in patients with meningioma.
Single-molecule Real-time (SMRT) Isoform Sequencing (Iso-Seq) in Plants: The Status of the Bioinformatics Tools to Unravel the Transcriptome Complexity
Authors: Gao Yubang , Xi Feihu , zhang Hangxiao , Liu Xuqing , Wang Huiyuan , zhao Liangzhen , Reddy Anireddy S.N. , Gu Lianfeng
Published: February 2019

Background:

The advent of the Single-Molecule Real-time (SMRT) Isoform Sequencing
(Iso-Seq) has paved the way to obtain longer full-length transcripts. This method was found to
be much superior in identifying full-length splice variants and other post-transcriptional events as
compared to the Next Generation Sequencing (NGS)-based short read sequencing (RNA-Seq).
Several different bioinformatics tools to analyze the Iso-Seq data have been developed and some
of them are still being refined to address different aspects of transcriptome complexity. However, a
comprehensive summary of the available tools and their utility is still lacking.

Objective:

Here, we summarized the existing Iso-Seq analysis tools and presented an integrated
bioinformatics pipeline for Iso-Seq analysis, which overcomes the limitations of NGS and generates
long contiguous Full-Length Non-Chimeric (FLNC) reads for the analysis of posttranscriptional
events.

Results:

In this review, we summarized recent applications of Iso-Seq in plants, which include improved
genome annotations, identification of novel genes and lncRNAs, identification of fulllength
splice isoforms, detection of novel Alternative Splicing (AS) and Alternative Polyadenylation
(APA) events. In addition, we also discussed the bioinformatics pipeline for comprehensive
Iso-Seq data analysis, including how to reduce the error rate in the reads and how to identify and
quantify post-transcriptional events. Furthermore, the visualization approach of Iso-Seq was discussed
as well. Finally, we discussed methods to combine Iso-Seq data with RNA-Seq for transcriptome
quantification.

Conclusion:

Overall, this review demonstrates that the Iso-Seq is pivotal for analyzing transcriptome
complexity and this new method offers unprecedented opportunities to comprehensively understand
transcripts diversity.
Biomolecular-Level Event Detection: A New Representation of Generating Short Sentence and Sample Selection Strategy
Authors: Lu Yang , Ma Xiaolei , Lu Yinan , Pei Zhili
Published: February 2019

Background:

Biomolecular-level event extraction is one of the most important branches
of information extraction. With the rapid growth of biomedical literature, it is difficult for researchers
to manually obtain information of interest, e.g. unknown information of threatening human
disease or some biological processes. Therefore, researchers are interested in automatically
acquiring information of biomolecular-level events. However, the annotated biomolecular-level
event corpus is limited and highly imbalanced, which affects the performance of the classification
algorithms and can even lead to over-fitting.
associations while known disease-lncRNA associations are required only.

Method:

In this paper, a new approach using the Pairwise model and convolutional neural network
for biomolecular-level event extraction is introduced. The method can identify more accurate positive
instances from unlabeled data to enlarge the labeled data. First, unlabeled samples are categorized
using the Pairwise model. Then, the shortest dependency path with additional information is
generated. Furthermore, two input forms with a new representation of the convolutional neural
network model, which are dependency word sequence and dependency relation sequence are presented.
Finally, with the sample selection strategy, the expanded labeled samples from unlabeled
domain corpus incrementally enlarge the training data to improve the performance of the classifier.

Result & Conclusion: Our proposed method achieved better performance than other excellent systems.
This is due to our new representation of generated short sentence and proposed sample selection
strategy, which greatly improved the accuracy of classification. The extensive experimental
results indicate that the new method can effectively inculcate unlabeled data to improve the performance
of classifier for biomolecular-level events extraction.
Partnership Efforts – Their Potential to Reduce the Challenges that Confront Regulators and Pharmaceutical Industry
Authors: Dhiman Sandeep Kumar , Gummadi Vikram , Dureja Harish
Published: February 2019

Background:

The healthcare is a highly regulated sector as it serves billions of population
globally. The two imperative pillars of this sector are pharmaceutical industry and health
regulatory authorities. While the industry acts as a supplier in this sector, regulators provide governance
to ensure quality, safety and efficacy of the healthcare products. Even though organizational
objectives of these two stakeholders are different, the by and large goal is to improve health
outcomes for populations. Both these entities are confronted by an assortment of challenges.

Objectives:

This study aims to draw attention towards such pain points and the potential of collaboration
and coordination efforts between these entities to mitigate these challenges. The industry
faces challenges that are driven by business needs and regulations. The major challenges faced
by the regulators are driven by the needs to ensure the safety, quality and efficacy of health care
products. Some of these challenges may have an overlap. Market scenario, patent/
exclusivities/return on investment issues, development costs, cost containment, quality and
GMP, scientific discovery productivity, novel therapies and technology, regulatory framework,
counterfeiting, supply chain challenges, Product life cycle management (PLM), patient centricity
approach, resources and financial constraints, process issues, protection of the public health, contemporizing
and growth of regulatory framework, political scenario in the country/region, unethical
clinical trials and research, healthcare policies, citizen participation, pharmacovigilance and
safety measures comprise a non-exhaustive list of challenges that confront industry and regulators.
Health authorities need to partner amongst them and with Pharmaceutical industry and continue to
innovate for novel ways of working to conquer these challenges. Organizations of international/
regional repute are known for their unique contribution in regulating the healthcare sector.
These bodies have helped to improve access to safe medicines more widely by harmonization of
drug quality, safety, and efficacy standards. These coordinated efforts have the potential to reduce
the numbers of challenges that confront the healthcare sector.

Conclusion:

The pharmaceutical industry and health regulators need to partner to achieve common
goal of healthcare. There is a growing need for these parties to come together on common
platforms and collaborate. The success of the strategies and approaches intended to deal with these
challenges depends upon strategic-level leadership and new ways of collaborative working, which
creates a room for potential synergies.