bluuebunny/crossref_metadata_2025 huggingface dataset:
Methodologies assessing digital technologies to assist “ageing in place”: a scoping review
Authors: Horne Francesca , Bailey Diane , Kenney Maggie
Published: September 2023

Purpose

Despite continuing workforce challenges over the last decade, the social care system is considered a key enabler in keeping older people out of hospital. In response to the workforce challenges, White Paper was released, which acknowledged the opportunities afforded by digital technology to assist older people ageing at home, often supported by informal caregivers. Given the policy emphasis on digital-enabled care, the most appropriate methods for evaluating its impact on social care outcomes have yet to be determined. The purpose this study was to review the current literature using a systematic approach to understand the methodological limitations to inform more robust evaluations in their use in future research.

Design/methodology/approach

This scoping review used a systematic approach adopting the framework of Arksey and O’Malley to examine studies examining the adoption of digital technologies to assist in older people’s ability to age in place.

Findings

The 21 relevant studies identified on digital technology to assist ageing-in-place are evolving. To date, it has focused on the efficacy and usability of the digital technologies themselves rather than investigating the impact of such technologies on re/enablement outcomes for older people. To rebalance this emphasis, there needs to be more research investigating the factors that enhance useability of digital technologies by older people and exploiting narrative data gained from qualitative research as they can provide valuable insights.

Originality/value

To the best of the authors’ knowledge, this is the first scoping review to consider qualitative methodological approaches for exploring ageing in place.
Comparing approaches to identify live births using the Transformed Medicaid Statistical Information System
Authors: Auty Samantha G. , Daw Jamie R. , Admon Lindsay K. , Gordon Sarah H.
Published: September 2023

Objective

To evaluate the performance of different approaches for identifying live births using Transformed Medicaid Statistical Information System Analytic Files (TAF).

Data Sources

The primary data source for this study were TAF inpatient (IP), other services (OT), and demographic and eligibility files. These data contain administrative claims for Medicaid enrollees in all 50 states and the District of Columbia from January 1, 2018 to December 31, 2018.

Study Design

We compared five approaches for identifying live birth counts obtained from the TAF IP and OT data with the Centers for Disease Control and Prevention (CDC) Natality data—the gold standard for birth counts at the state level.

Data Collection/Extraction Methods

The five approaches used varying combinations of diagnosis and procedure, revenue, and place of service codes to identify live births. Approaches 1 and 2 follow guidance developed by the Centers for Medicare and Medicaid Services (CMS). Approaches 3 and 4 build on the approaches developed by CMS by including all inpatient hospital claims in the OT file and excluding codes related to delivery services for infants, respectively. Approach 5 applied Approach 4 to only the IP file.

Principal Findings

Approach 4, which included all inpatient hospital claims in the OT file and excluded codes related to infants to identify deliveries, achieved the best match of birth counts relative to CDC birth record data, identifying 1,656,794 live births—a national overcount of 3.6%. Approaches 1 and 3 resulted in larger overcounts of births (20.5% and 4.5%), while Approaches 2 and 5 resulted in undercounts of births (−3.4% and −6.8%).

Conclusions

Including claims from both the IP and OT files, and excluding codes unrelated to the delivery episode and those specific to services rendered to infants improves accuracy of live birth identification in the TAF data.
Machine learning in clinical practice: Evaluation of an artificial intelligence tool after implementation
Authors: Akhlaghi Hamed , Freeman Sam , Vari Cynthia , McKenna Bede , Braitberg George , Karro Jonathan , Tahayori Bahman
Published: September 2023

Objective

Artificial intelligence (AI) has gradually found its way into healthcare, and its future integration into clinical practice is inevitable. In the present study, we evaluate the accuracy of a novel AI algorithm designed to predict admission based on a triage note after clinical implementation. This is the first of such studies to investigate real‐time AI performance in the emergency setting.

Methods

The novel AI algorithm that predicts admission using a triage note was translated into clinical practice and integrated within St Vincent's Hospital Melbourne's electronic emergency patient management system. The data were collected from 1 January 2021 to 17 August 2022 to evaluate the diagnostic accuracy of the AI system after implementation.

Results

A total of 77 125 ED presentations were included. The live AI algorithm has a sensitivity of 73.1% (95% confidence interval 72.5–73.8), specificity of 74.3% (73.9–74.7), positive predictive value of 50% (49.6–50.4) and negative predictive value of 88.7% (88.5–89) with a total accuracy of 74% (73.7–74.3). The accuracy of the system was at the lowest for admission to psychiatric units (34%) and at the highest for gastroenterology and medical admission (84% and 80%, respectively).

Conclusion

Our study showed the diagnostic evaluation of a real‐time AI clinical decision‐support tool became less accurate than the original. Although real‐time sensitivity and specificity of the AI tool was still acceptable as a decision‐support tool in the ED, we propose that continuous training and evaluation of AI‐enabled clinical support tools in healthcare are conducted to ensure consistent accuracy and performance to prevent inadvertent consequences.
Use of 16S rRNA gene sequences to identify cyanobacteria that can grow in far‐red light
Authors: Ko Jui‐Tse , Li Ying‐Yang , Chen Pa‐Yu , Liu Po‐Yu , Ho Ming‐Yang
Published: September 2023

Although most cyanobacteria use visible light (VL; λ = 400–700 nm) for photosynthesis, some have evolved strategies to use far‐red light (FRL; λ = 700–800 nm). These cyanobacteria are defined as far‐red light‐utilizing cyanobacteria (FRLCyano), including two groups: (1) chlorophyll d‐producing Acaryochloris spp. and (2) polyphyletic cyanobacteria that produce chlorophylls d and f in response to FRL. Numerous ecological studies examine pigments, such as chlorophylls d and f, to investigate the presence of FRLCyano in the environment. This method is not ideal because it can only detect FRLCyano that have made chlorophylls d or f. Here we develop a new method, far‐red cyanobacteria identification (FRCI), to identify FRLCyano based on 16S rRNA gene sequences. From public databases and published articles, 62 16S rRNA gene sequences of FRLCyano were extracted. Comparing with related lineages, we determined that 97% sequence identity is the optimal cut‐off for distinguishing FRLCyano from other cyanobacteria. To test the method experimentally, we collected samples from 17 sites in Taipei, Taiwan, and conducted VL and FRL enrichments. Our results demonstrate that FRCI can detect FRLCyano during FRL enrichments more sensitively than pigment analysis. FRCI can also resolve the composition of FRLCyano at the genus level, which pigment analysis cannot do. In addition, we applied FRCI to published datasets and discovered putative FRLCyano in diverse environments, including soils, hot springs and deserts. Overall, our results indicate that FRCI is a sensitive and high‐resolution method using 16S rRNA gene sequences to identify FRLCyano.
Clinical characteristics and prognostic impact of acute exacerbations in patients with interstitial lung disease and lung cancer: A single‐center, retrospective cohort study
Authors: Hyun Dong‐gon , Han Soo Jin , Ji Wonjun , Choi Chang‐Min , Lee Jae Cheol , Kim Ho Cheol
Published: September 2023

Background

Although acute exacerbation (AE) after treatment for lung cancer (LC) is a poor prognostic factor in patients with interstitial lung disease associated with lung cancer (ILD‐LC), the risk of AE according to cancer treatment type remains unclear. Therefore, in the present study, we aimed to investigate the association between AE and treatment received for LC in patients with ILD‐LC.

Methods

We conducted a retrospective study of patients with ILD‐LC who had undergone treatment for LC between January 2018 and December 2022. The primary study outcome was the incidence of AE within 12 months of treatment for LC according to treatment type. The association between AE and all‐cause mortality was evaluated as a secondary outcome.

Results

Among a total of 137 patients, 23 (16.8%) developed AE within 12 months of treatment for LC. The incidence of AE according to treatment type was 4.3% for surgery, 16.2% for radiotherapy, 15.6% for chemotherapy, and 54.5% for concurrent chemoradiation therapy (CCRT). Patients who received CCRT were more likely to develop AE, even after adjustment for covariables (hazard ratio [HR], 15.39; 95% confidence interval [CI]: 4.00–59.19; p < 0.001). In addition, AE within 12 months of treatment for LC was associated with an increased risk of all‐cause mortality (HR, 2.82; 95% CI: 1.13–7.04; p = 0.026).

Conclusion

Among treatment options for patients with ILD‐LC, CCRT was associated with an increased risk for AE. In addition, patients with AE had a higher mortality rate than patients without AE.
Evaluation of the inhibitory effect of azoles on pharmacokinetics of lenvatinib in rats both in vivo and in vitro by UPLC‐MS/MS
Authors: Xia Mengming , Song Xueyi , Lu Zebei , Wang Yu , Zhou Quan , Geng Peiwu , Wang Shuanghu , Zhou Yunfang , Wu Qingjun , Han Aixia
Published: September 2023

Background

Lenvatinib is a multitargeted tyrosine kinase inhibitor used in the treatment of a variety of solid tumors. This study aims to investigate the potential pharmacokinetic interactions between lenvatinib and various azoles (ketoconazole, voriconazole, isavuconazole and posaconazole) when orally administered to rats.

Methods

A total of 30 Sprague–Dawley rats were randomly allocated into five groups and administered 20 mg/kg of ketoconazole, voriconazole, isavuconazole and 30 mg/kg of posaconazole and 0.5% CMC‐Na, through gavage for a duration of 7 days prior to the commencement of the experiment. On the final day, the rats were given 10 mg/kg of lenvatinib. The blood concentration of lenvatinib was determined using UPLC‐MS–MS. In vitro lenvatinib were incubated with azoles and rat liver microsomes (RLMs) or human liver microsomes (HLMs). Molecular docking was lastly used to examine the binding strength of the enzymes and ligands with Autodock Vina.

Results

AUC and Cmax of lenvatinib significantly increased with each of the azoles (p < 0.05), whereas CLz/F decreased 0.83‐flod, 0.41‐fold (p < 0.05) and 0.72‐fold (p < 0.01) in voriconazole, isavuconazole and ketoconazole in rats. The IC50 of lenvatinib with the azoles were 0.237, 1.300, 0.355 and 2.403 μM in RLMs and 0.160, 1.933, 3.622 and 1.831 μM in HLMs. Molecular docking analysis suggested that azoles exhibited a strong binding ability towards the target enzymes.

Conclusion

It is imperative to acknowledge the potential drug–drug interactions mediated by CYP3A4 between azoles and lenvatinib, as these interactions hold significant implications for their clinical utilization.
Oviposition by the oriental fruit fly, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), on five citrus types in a laboratory
Authors: Theron Charmaine D. , Kotzé Zanthé , Manrakhan Aruna , Weldon Christopher W.
Published: September 2023

Frugivorous insects use visual, chemical and tactile cues to find a suitable host for oviposition. However, these cues can vary greatly among fruit cultivars and condition, changing their susceptibility to fruit fly oviposition. The aims of this study were to (1) determine the effects of ripeness stage and damage on oviposition propensity by sexually mature, mated female oriental fruit flies, Bactrocera dorsalis (Hendel) (Diptera: Tephritidae), on five citrus types (species and cultivars) under choice and no‐choice conditions and (2) describe the oviposition behaviour of B. dorsalis on ripe fruit of the same five citrus types that were either damaged or undamaged under no‐choice conditions. All tests were conducted in the laboratory. The citrus types tested were Citrus sinensis (L.) Osbeck cv Delta Valencia orange, Citrus sinensis (L.) Osbeck cv Glen Ora Late navel orange, Citrus limon (L) (Burm.f.) cv Eureka lemon, Citrus paradisi (Macfad.) cv Star Ruby grapefruit and Citrus reticulata (Blanco) cv Nadorcott mandarin. Peel physical properties and essential oil composition were determined for each citrus type and stage. Oviposition propensity of B. dorsalis was significantly greater on damaged citrus but was not correlated with fruit diameter, peel thickness, oil gland density or oil gland size. A total of 45 aromatic compounds were found to be significant between the five cultivars investigated, and 6 of 11 compounds were significantly associated with over‐ripe fruits. Bactrocera dorsalis spent a significantly greater proportion of time ovipositing in damaged citrus and showed higher aggression when oviposition occurred in undamaged citrus. These results suggest that the removal of damaged and fallen fruit is important for controlling this pest in citrus orchards.
Racgap1 knockdown results in cells with multiple cilia due to cytokinesis failure
Authors: Basu Basudha , Lake Alice V. R. , China Becky , Szymanska Katarzyna , Wheway Gabrielle , Bell Sandra , Morrison Ewan , Bond Jacquelyn , Johnson Colin A.
Published: September 2023

Most mammalian cells have a single primary cilium that acts as a signalling hub in mediating cellular functions. However, little is known about the mechanisms that result in aberrant supernumerary primary cilia per cell. In this study, we re‐analysed a previously published whole‐genome siRNA‐based reverse genetic screen for genes mediating ciliogenesis to identify knockdowns that permit multi‐ciliation. We identified siRNA knockdowns that caused significant formation of supernumerary cilia, validated candidate hits in different cell‐lines and confirmed that RACGAP1, a component of the centralspindlin complex, was the strongest candidate hit at the whole‐genome level. Following loss of RACGAP1, mother centrioles were specified correctly prior to ciliogenesis and the cilia appeared normal. Live cell imaging revealed that increased cilia incidence was caused by cytokinesis failure which led to the formation of multinucleate cells with supernumerary cilia. This suggests that the signalling mechanisms for ciliogenesis are unable to identify supernumerary centrosomes and therefore allow ciliation of duplicated centrosomes as if they were in a new diploid daughter cell. These results, demonstrating that aberrant ciliogenesis is de‐coupled from cell cycle regulation, have functional implications in diseases marked by centrosomal amplification.
Adjuvant chemotherapy improves survival amongst octogenarians following resection of colorectal adenocarcinoma
Authors: Fernando Dhanushke , Hanna Joseph , Cohen Ryan , Ryan Jennifer
Published: September 2023

Background

The Australian population is ageing, with an increasing number of patients diagnosed with colorectal cancer in their eighth decade. This group represents a challenging cohort to deliver multidisciplinary care, with increased morbidity and mortality related to surgical and oncological therapies. This project aimed to compare surgical and oncological outcomes in octogenarian and non‐octogenarian patients with colorectal cancer.

Methods

A matched case–control retrospective review of a prospectively maintained institutional database of colorectal cancer patients treated between 2005 and 2021 was conducted. Patient demographics, treatment details, peri‐operative complications, and long‐term survival were reported. The primary outcome, cancer‐specific survival, was investigated using time‐to‐event analysis and interrogated with multivariate regression.

Results

There were 747 patients included in the study. There was no difference in five‐year cancer‐specific survival and recurrence‐free survival between cohorts. Multivariate analysis for octogenarians confirmed a significant hazard signal associated with worsening cancer stage and a survival benefit associated with the administration of adjuvant therapy. However, we noted that stage‐matched octogenarian patients received less adjuvant treatment compared to non‐octogenarians.

Conclusion

Octogenarians undergoing treatment for colorectal cancer have similar cancer‐specific survival and recurrence‐free survival to non‐octogenarians. Our study demonstrates a survival benefit when adjuvant therapy is provided to octogenarians, despite only half of this cohort receiving therapy compared to their younger peers. Further research into adjuvant therapy with surgical resection for CRC in older Australians is required.
Hard tissue stability outside the buccal bone arch contour after guided bone regeneration in the anterior maxilla: A retrospective cohort radiographic study
Authors: Gao Yang , Gao Shaojingya , Yao Yangxue , Cai Xiaoxiao
Published: September 2023

Objectives

To radiographically evaluate the stability of the bone substitute augmented outside the buccal bony arch contour in the maxillary esthetic zone.

Materials and Methods

Patients who missed a single anterior tooth and received simultaneous GBR in implant surgery were included. The contralateral homonymous area of the implant site was horizontally mirrored as the individual bone arch contour. According to the relative position of the postoperative buccal grafts and bone arch contour at the implant shoulder, 62 patients were allocated into the outside‐contour (OC) and inside‐contour (IC) groups. Cone‐beam computed tomography was performed before surgery, after implant insertion, before re‐entry surgery, and at follow‐up. The profilometric changes of the buccal bone plate were analyzed via the bone distance to the mirrored bony contour.

Results

At the implant shoulder, the bone distance in the OC group was higher than that in the IC group, with statistically significant differences at re‐entry surgery and follow‐up. However, the bone grafts outside the bone arch contour were reduced into the contour after remodeling and showed more bone resorption than the IC group. At other vertical levels below the implant shoulder, bony grafting of overcontour 1–2 mm range was favorable to regenerate stable bone plates reaching the individual contour at follow‐up.

Conclusions

The overaugmented bone outside the buccal bone arch contour tended to remodel into the original contour, which indicates that the anterior bone arch contour is worthy of careful observation for deciding buccolingual implant position and bone augmentation width.
A semantically enhanced text retrieval framework with abstractive summarization
Authors: Pan Min , Li Teng , Liu Yu , Pei Quanli , Huang Ellen Anne , Huang Jimmy X.
Published: September 2023

Recently, large pretrained language models (PLMs) have led a revolution in the information retrieval community. In most PLMs‐based retrieval frameworks, the ranking performance broadly depends on the model structure and the semantic complexity of the input text. Sequence‐to‐sequence generative models for question answering or text generation have proven to be competitive, so we wonder whether these models can improve ranking effectiveness by enhancing input semantics. This article introduces SE‐BERT, a semantically enhanced bidirectional encoder representation from transformers (BERT) based ranking framework that captures more semantic information by modifying the input text. SE‐BERT utilizes a pretrained generative language model to summarize both sides of the candidate passage and concatenate them into a new input sequence, allowing BERT to acquire more semantic information within the constraints of the input sequence's length. Experimental results from two Text Retrieval Conference datasets demonstrate that our approach's effectiveness increasing as the length of the input text increases.
Classic biphasic pulmonary blastoma: A case report and review of the literature from 2000 to 2022
Authors: Yao Hui , Jiang Xin , Zeng Ying , Wang Xue , Tang Xuefeng
Published: September 2023

Classic biphasic pulmonary blastoma (CBPB), a distinct type of lung cancer, is a dual‐phasic tumor characterized by the co‐existence of low‐grade fetal adenocarcinoma and primitive mesenchymal stroma. Accounting for less than 0.1% of surgically removed lung cancers, CBPB commonly presents in individuals during their fourth to fifth decades of life, with smoking as a significant risk factor. The optimal management strategy entails surgical resection, supplemented by chemotherapy to improve prognosis. The frontline chemotherapeutic agents typically include platinum agents and etoposide, with preoperative neoadjuvant chemotherapy potentially enabling operability for initially inoperable cases. In recent years, targeted therapies, such as antiangiogenic agents, have emerged as promising new treatment strategies for CBPB. For patients exhibiting brain metastases or deemed inoperable, radiation therapy proves to be a crucial therapeutic component. CBPB prognosis is adversely affected by factors such as early metastasis, tumor size exceeding 5 cm, and tumor recurrence. In this regard, serological markers have been identified as valuable prognostic indicators. To exemplify, we recount the case of a 44‐year‐old female patient with CBPB, wherein serum lactate dehydrogenase levels showed significant diagnostic value. This report further incorporates a comprehensive review of CBPB literature from the past 22 years.
Neoplastic or inflammatory? A case report of Sweet syndrome with CD30+ cells in a patient with B‐lymphoblastic leukemia
Authors: Ehyaee Vida , Reddy Vijaya , Ahmed Aadil
Published: September 2023

CD30+ cells are typically part of lymphoproliferative disorders but can also be seen in inflammatory dermatoses. We present a case of 47‐year‐old man with a history of B‐lymphoblastic leukemia (B‐ALL) who presented with fever, leukocytosis, and papulonodular skin lesions, involving the extremities and trunk. A punch biopsy specimen demonstrated papillary dermal edema with a neutrophilic and histiocytic infiltrate extending into the subcutis. The infiltrate also harbored scattered large cells that were positive for CD30 and demonstrated the immunohistochemical profile of monocytes. A diagnosis of histiocytoid Sweet syndrome with CD30+ cells was made. The case is unique, demonstrating a combination of Sweet syndrome variants with subcutis involvement, histiocytoid morphology, and large CD30+ cells. A prior history of B‐ALL and immunohistochemical profile of monocytes with immature morphology broadened the differential diagnosis and added to the diagnostic challenge.
Construction and application of dental virtual reality simulation teaching system in China: Necessity and strategies
Authors: Lu Junzhuo , Zhang Linglin , Ye Ling
Published: September 2023

Introduction

Following worldwide progress in digital technology, the utilization of advanced technology to update the concept and mode of education has become an important way to improve the quality and scale of talent training. Adoption of virtual reality technology has a positive effect on dental education. Virtual reality technology has been introduced into Chinese dental education nearly 10 years ago, and a holistic teaching system that employs virtual simulation technology to assist instructors in teaching and students in learning has gradually been formed.

Materials and Methods

Based on the work of the West China School of Stomatology, Sichuan University, we introduced the necessity and advantages of the application of virtual simulation technology in talent training in dentistry and the status of this teaching system.

Results

A virtual dental simulation teaching system was constructed and applied in China. Virtual reality technology was incorporated into the four elements of the teaching system. This reformed system carried out educational informatization in terms of the construction of a virtual simulation teaching platform, development of virtual simulation teaching resources, improvement of the student training model, and upgrading of teaching management.

Conclusion

The holistic teaching system implemented at the West China School of Stomatology, Sichuan University, highlights the successful incorporation of virtual reality technology into various aspects of dental education. The construction of this system reflects the deep integration of modern information technology and dental education, with the aim of helping dental educators promote teaching methods and management model in the future.
Effects of invasive clam (Corbicula fluminea) die‐offs on the structure and functioning of freshwater ecosystems
Authors: Novais Adriana , Batista Daniela , Cássio Fernanda , Pascoal Cláudia , Sousa Ronaldo
Published: September 2023

Freshwater ecosystems are highly susceptible to the impacts of global climate change, including extreme events such as floods and droughts. These impacts may be influenced by the presence of widespread invasive alien species, such as the Asian clam Corbicula fluminea (Cyrenidae).

The high density and biomass attained by C. fluminea in the Minho River (NW Iberian Peninsula) are responsible for several ecological impacts. By using a manipulative experiment under natural conditions, we assessed the effects of C. fluminea die‐offs on the structure of microbial (fungi and bacteria) and invertebrate communities and leaf‐litter breakdown.

Results suggested that C. fluminea die‐offs did not affect the structure of microbial and invertebrate communities nor litter breakdown rate. However, differences in temporal dynamics were detected and followed an ecological succession during the experiment.

Our study revealed that the presence of live C. fluminea stimulated fungal biomass and leaf mass loss, probably due to an increased availability of nutrients via production of faeces and pseudofaeces.
Size‐based interactions and trophic transfer efficiency are modified by fish predation and cyanobacteria blooms in Lake Mývatn, Iceland
Authors: Ersoy Zeynep , Jeppesen Erik , Sgarzi Serena , Arranz Ignasi , Cañedo‐Argüelles Miguel , Quintana Xavier D. , Landkildehus Frank , Lauridsen Torben L. , Bartrons Mireia , Brucet Sandra
Published: September 2023

Trophic cascade studies have so far mostly focused on changes in the abundance, biomass, or average size of prey and predators. In contrast, individual size‐based interactions, playing a key role in the trophic structure and functioning of aquatic ecosystems, have been less explored.

We conducted a 3‐month in situ experiment in Lake Mývatn, Iceland, with two fish treatments (with and without fish, Gasterosteus aculeatus). After the first month of the experiment, Anabaena blooms appeared in the lake. We studied the effects of fish predation and occurrence of cyanobacteria blooms on the individual size structure (i.e. the distribution of the number of organisms over a size range) of zooplankton and phytoplankton. We also assessed the potential consequences for trophic transfer efficiency (TTE) (measured as the predator to prey biomass ratio) in the planktonic food web.

Our results showed that fish predation and cyanobacteria bloom had a negative relationship with size diversity of zooplankton, which became dominated by small‐sized individuals in both cases. The phytoplankton size diversity changed over time particularly due to the blooming of large‐sized Anabaena, and its increase was apparently mainly driven by changes in resources.

Low zooplankton size diversity related to fish predation reduced TTE, particularly in the enclosures with fish. This may be because low zooplankton size diversity represents a lower partition of resources among consumers, thereby decreasing the trophic energy transfer. With the occurrence of Anabaena bloom, high phytoplankton size diversity coincided with a lower energy transfer in all enclosures likely due to reduced zooplankton grazing when large‐sized colony‐forming Anabaena dominated.

In conclusion, our results indicate that both top‐down and bottom‐up forces significantly influence the size structure of planktonic communities. The changes in size structure were related to shifts in the energy transfer efficiency of the Lake Mývatn food web. Thus, our study underpins the importance of taking into account size‐based interactions in the study of trophic cascades, particularly in a warming climate where strong planktivorous fish predation and frequent cyanobacteria blooms may occur.
ETHNIC SEGREGATION DURING PUBLIC AND NATIONAL HOLIDAYS: A STUDY USING MOBILE PHONE DATA
Authors: Mooses Veronika , Silm Siiri , Ahas Rein
Published: September 2023

This paper contains an analysis of ethnic differences in activity locations during public and national holidays. Holidays relate to identity, and the celebration of holidays can be a very important part of acculturation processes and are therefore relevant to ethnic integration policies. We study the out‐of‐home nonemployment activity locations of 12,500 respondents in Estonia, using mobile phone positioning data. The results show that during holidays, ethnic segregation, measured using an index of dissimilarity, is significantly higher than it is on regular days, especially outside the capital city. The type of holiday, such as whether it is a national or international holiday, has a particular effect on people's spatial behaviour. On Estonian public holidays, Estonians are more likely to leave Tallinn than Russian speakers. There are 77 per cent more Estonians and 33 per cent more Russian speakers outside the capital than on non‐holidays. The paper depicts different temporal layers of segregation, which also indicates different integration potential in leisure spaces under various time frames.
A new, all‐encompassing aetiology of type 1 diabetes
Authors: de Groen Piet C.
Published: September 2023

The aetiology of type 1 diabetes (T1D) is considered multifactorial with the contribution of the MHC on chromosome 6 being most important. Multiple factors also contribute to the aetiology of colorectal neoplasia, but the final event causing the change from normal mucosa to polyp and from polyp to cancer is due to a single somatic mutation event. Repeated formation of colorectal neoplasia within an at‐risk population results in a predictable, tapering, exponential neoplasia distribution. Critical mutations driving colorectal neoplasia formation occur in mutation‐prone DNA. These observations led to three hypotheses related to T1D. First, a single somatic mutation within the MHC of antigen presenting cells results in a change in phenotype from normal to T1D. Second, the distribution of additional autoimmune diseases (AAIDs) among persons with T1D adheres to a predictable, tapering, exponential distribution. And third, critical mutations driving development of T1D occur in mutation‐prone DNA. To address the hypotheses in an orderly fashion, a new analytical method called genome‐wide aetiology analysis (GWEA) consisting of nine steps is presented. All data required for GWEA of T1D are obtained from peer‐reviewed publications or publicly available genome and proteome databases. Critical GWEA steps include AAID distribution among persons with T1D, analysis of at‐risk HLA loci for mutation‐prone DNA, determination of the role of non‐MHC genes on GWAS, and verification of human data by cell culture or animal experiments. GWEA results show that distribution of AAID among persons with T1D adheres to a predictable, tapering, exponential distribution. A single, critical, somatic mutation within the epitope‐binding groove of at‐risk HLA loci alters HLA‐insulin‐peptide‐T‐cell‐receptor (TCR) complex binding affinity and creates a new pathway that leads to loss of self‐tolerance. The at‐risk HLA loci, in particular binding pockets P1, P4 and P9, are encoded by mutation‐prone DNA: GC‐rich DNA sequence and somatic hypermutation hotspots. All other genes on GWAS can but do not have to amplify the new autoimmune pathway by facilitating DNA mutations, changing peptide binding affinity, reducing signal inhibition or augmenting signal intensity. Animal experiments agree with human studies. In conclusion, T1D is caused by a somatic mutation within the epitope‐binding groove of an at‐risk HLA gene that affects HLA‐insulin‐peptide‐TCR complex binding affinity and initiates an autoimmune pathway. The nature of the peptide that binds to a mutated epitope‐binding groove of an at‐risk HLA gene determines the type of autoimmune disease that develops, that is, one at‐risk HLA locus, multiple autoimmune diseases. Thus, T1D and AAIDs, and therefore common autoimmune diseases, share a similar somatic mutation‐based aetiology.
Still part of the game—corporatism and political exchanges in two small states
Authors: Mailand Mikkel
Published: September 2023

This study of Danish and Dutch work and welfare policies since the Great Recession questions the dominant picture of trade unions as being too weak and irrelevant for tripartite regulation. The frequency of tripartite agreements has not decreased, and social partners are still able to obtain important concessions. In addition to well‐described resources, the article shows that trade unions and employers' organizations offer governments financial resources and access to workplaces in political exchanges, which helps explain corporatist resilience. Only limited support was found for well‐known drivers other than economic crises as explanations for changes over time in tripartism.
Model transferability and predicted response of a dryland anuran to climate change in the Southwest United States
Authors: de Albuquerque Fabio Suzart , Bateman Heather L. , Ryan Mason J. , Montgomery Brett
Published: September 2023

Aim

We propose a combined approach to explore the model transferability and the effect of climate change on habitat suitability.

Location

Southwest United States.

Taxon

Amphibians; Anura; Bufonidae; Anaxyrus microscaphus.

Methods

To assess the impacts of climate change on A. microscaphus, we obtained 3162 records from the Arizona Game and Fish Department. We classified occurrence records data into six historical groups (from 1960 to 2018) and a contemporary group (from 2019 to 2022). We investigated the ability of historical data to generate accurate predictions of the species' contemporary distribution. We used species distribution modelling to compute habitat suitability values and identified spatial clusters of high suitability values (using hotspot analyses).

Results

We show that historical occurrences successfully predicted the contemporary distribution of A. microscaphus. We demonstrate that the geographical distribution of contemporary hotspots is strongly related to precipitation of the wettest quarter. This research provides evidence that climate change will likely affect the distribution of hotspots and the habitat suitability of A. microscaphus. Losses of 37%–48% contraction are expected at the margins of the range both in the north and south of the geographic limits.

Main Conclusions

We show that recent past data can be used to predict contemporary species distribution accurately. We highlight that habitat suitability values of A. microscaphus are strongly related to climate, topography and distance to streams. This study provides clear evidence of the negative impacts of climate change on habitat suitability in the Southwest United States drylands. Our approach has applied utility to managers to target survey areas, monitor habitat changes, plan for conservation mitigation measures, conserve stream flows across the species' range and inform recovery if needed. Thus, managers could use previously collected data to predict contemporary species distribution when their occurrence accurately characterizes the species' ecological niche.
The oncogenic role of SAMMSON lncRNA in tumorigenesis: A comprehensive review with especial focus on melanoma
Authors: Ghasemian Majid , Babaahmadi‐Rezaei Hossein , Khedri Azam , Selvaraj Chandrabose
Published: September 2023

LncRNA Survival Associated Mitochondrial Melanoma Specific Oncogenic Non‐coding RNA (SAMMSON) is located on human chromosome 3p13, and its expression is upregulated in several tumours, including melanoma, breast cancer, glioblastoma and liver cancer and has an oncogenic role in malignancy disorders. It has been reported that SAMMSON impacts metabolic regulation, cell proliferation, apoptosis, EMT, drug resistance, invasion and migration. Also, SAMMSON is involved in regulating several pathways such as Wnt, MAPK, PI3K, Akt, ERK and p53. SAMMSON is considered a potential diagnostic and prognostic biomarker in several types of cancer and a suitable therapeutic target. In addition, the highly expressed SAMMSON is closely associated with clinicopathological features of various cancers. SAMMSON has a significant role in regulating epigenetic processes by regulating histone protein or the status of DNA methylation. Herein for the first time, we comprehensively summarized the currently available SAMMSON, molecular regulatory pathways, and clinical significance. We believe that clarifying all the molecular aspects of this lncRNA can be a good guide for cancer studies in the future.
Non‐directed (altruistic) kidney donation: Altruism or insurance policy?
Authors: Armitage Richard C.
Published: September 2023

Introduction

Since non‐directed (altruistic) kidney donors do not stand to benefit from the lengthening and strengthening of a relationship that they intrinsically value, their donations are considered to constitute the most altruistic variety of living kidney donation.

Methodology

This paper uses publicly‐available data to assess the expected value that accrues to the donor of altruistic kidney donation.

Findings

Compared to healthy non‐donors, living kidney donors experience only marginally increased absolute risks of poor physical health outcomes, and no difference in important psychosocial health outcomes. Crucially, the chance of requiring a kidney donation is only marginally increased by becoming a living kidney donor. In the United Kingdom, previous living kidney donors that subsequently become in need of any organ donation (not only kidneys) themselves are considered priority patients for these donations. They consequently experience shorter waiting times for these organs and reduced exposure to the inherently harmful effects of dialysis therapy (if a kidney donation is required) compared to non‐donors in need of organ donation. As such, while key data points required to compute an accurate and complete expected value calculation are unavailable, it is likely that the additional risk incurred by becoming a living kidney donor is outweighed by the benefit of being considered a priority patient for the donation of any type of organ in the event that this is needed.

Conclusion

Accordingly, the expected value of becoming a living kidney donor is likely to be positive, meaning the act of doing so may be considered akin to the taking out of an insurance policy. In the context of non‐directed (altruistic) kidney donation, this may diminish the extent to which such a donation is considered altruistic.
Measuring urban waterlogging depths from video images based on reference objects
Authors: Gao Kai , Yang Zhiyong , Gao Xichao , Shao Weiwei , Wei Haokun , Xu Tianyin
Published: September 2023

Camera surveillance systems can record urban waterlogging processes. Objects with regular shapes and fixed sizes captured by the camera can be utilized to calculate urban waterlogging depths based on geometric principles. In this study, we propose a machine learning‐based method to measure urban waterlogging depths using wheels and traffic buckets captured in video images as reference objects. This method is validated through laboratory experiments and observed data. The results demonstrate that: (1) the urban waterlogging depths calculated using urban reference objects show high consistency with the observed water level data; (2) in the laboratory scenario, the probability of error within 3 cm for measurements based on the hub, tire, and traffic bucket are 99.07%, 99.38%, and 81.55%, respectively; (3) in the real‐world scenario, the probability of error within 3 cm for measurements based on car hubs and pickup truck hubs are 97.30% and 95.14%, respectively. In conclusion, urban waterlogging depths can be accurately measured using reference objects with regular shapes. The proposed method can help obtain waterlogging data with higher temporal and spatial resolution at lower economic costs, which is of great significance for urban flood control.
Risk of recurrent advanced colorectal neoplasia in individuals with baseline non‐advanced neoplasia followed up at 5 vs 7–10 years
Authors: Wong Martin C. S. , Leung Eman Yee‐man , Chun Sam C. C. , Deng Yunyang , Lam Thomas , Tang Raymond S. Y. , Huang Junjie
Published: September 2023

Background and Aim

Colorectal cancer (CRC) is one of the commonest cancers, especially among the Asian populations. We compared the recurrence rate of advanced colorectal neoplasia (ACN) at 5 year vs 7–10 years among individuals with non‐advanced adenoma (NAA) detected and polypectomized at baseline colonoscopy in a large Chinese population.

Methods

We extracted data of a large Chinese population with NAA polypectomized who received surveillance colonoscopy after 5 or 7–10 years from a large database (2008–2018). The outcome variable included recurrence of ACN at surveillance colonoscopy. We examined the association between length of surveillance and the outcome variable, whilst controlling for risk factors of colorectal cancer.

Results

We include 109 768 subjects who have received a baseline colonoscopy from our dataset. They were aged 67.35 (SD 9.84) years, and 60.9% of them were male subjects. The crude 5‐year and 10‐year recurrence rate of ACN was 1.50% and 2.42%, respectively (crude odds ratio = 1.629, 95% CI 1.362 to 1.949, P < 0.001). From the binary logistic regression model, individuals with surveillance colonoscopy performed at 10 years had a statistically higher recurrence rate of ACN than those followed‐up at 5 year (adjusted odds ratio [aOR] = 1.544, 95% CI 1.266 to 1.877, P < 0.001), but the effect size of aOR is small.

Conclusions

There is a small difference in recurrence of ACN between individuals who received colonoscopy workup at 5 years vs 7–10 years. These findings support a 7–10 years surveillance period after baseline NAA was polypectomized.
Impact of vitamin D deficiency on mortality in patients with hip fracture: A meta‐analysis
Authors: Llombart Rafael , Mariscal Gonzalo , Barrios Carlos , de la Rubia Ortí Jose Enrique , Llombart‐Ais Rafael
Published: September 2023

Background

Vitamin D deficiency has been linked to numerous health issues, including an increased risk of hip fractures. This meta‐analysis aimed to investigate the relationship between vitamin D deficiency and mortality in patients with hip fracture. To assess the impact of different levels of vitamin D deficiency on mortality in patients with hip fractures and examine the influence of potential confounding factors.

Methods

A systematic search of PubMed, EMBASE, Scopus, and Cochrane Collaboration Library was conducted, resulting in nine eligible cohort studies (n = 4409). Patients with hip fractures were categorized based on their vitamin D levels as severe, moderate, or insufficient. Mortality was the primary outcome measure in this study. Subgroup analyses were performed according to the follow‐up time. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using a random‐effects model in Review Manager 5.4.

Results

Nine studies, with a pool of 4409 patients, were included. Vitamin D insufficiency was significantly associated with increased mortality (OR 1.24, 95% CI 1.05–1.46; I2 = 4%). Severe deficiency also led to a significant increase in mortality (OR 2.08, 95% CI 1.09–3.97; I2 = 42%), whereas moderate deficiency did not show a significant effect (OR 1.06, 95% CI 0.79–1.44; I2 = 0%). Subgroup analysis revealed significant associations between vitamin D insufficiency and increased mortality at 1‐year (OR 1.37, 95% CI 1.06–1.77) and 2‐year follow‐ups (OR 1.78, 95% CI 1.01–3.15). After adjusting for potential confounders, no significant increase in the mortality rate was observed.

Conclusions

This meta‐analysis suggests that vitamin D insufficiency and severe deficiency are associated with increased mortality in patients with hip fracture. However, after adjusting for confounding factors, this association was not statistically significant. Further research is necessary to understand the role of vitamin D deficiency in this population.
Recurrence and survival in dogs with excised colorectal polyps: A retrospective study of 58 cases
Authors: Méric Tristan , Issard Julien , Maufras Thomas , Hugonnard Marine , Senecat Odile , Lecoindre Alexis , Leal Rodolfo Oliveira , Bertolani Coralie , Toulza Olivier , Lecoindre Patrick , Brisebard Elise , Ledevin Mireille , Larcher Thibaut , Drut Amandine , Darnis Elodie , Hernandez Juan
Published: September 2023

Background

Compared to humans, colorectal polyps are relatively rare in dogs. Epidemiological and prognostic data remain accordingly sparse, although they could help veterinary clinicians in the management of these cases.

Objectives

To report the epidemiological data of dogs with colorectal polyps and identify factors associated with recurrence and survival.

Animals

Fifty‐eight client‐owned dogs with colorectal polyps admitted to 7 veterinary hospitals (53 dogs from France, 5 dogs from Spain, and 4 dogs from Portugal) were included.

Methods

Retrospective multicentric cohort study. Medical records and long‐term outcome of the dogs were reviewed. When available, histological samples were reassessed by 2 board‐certified pathologists according to the revised Vienna classification (RVC).

Results

The West Highland White Terrier (WHWT) breed was significantly associated with the presence of colorectal polyps (OR: 20; 95% CI: 7.5‐52; P < .001). The overall median time to recurrence was not reached after 2000 days. The overall estimated median survival time was 1640 days. WHWT breed and larger polyps were significantly associated with a shorter time of polyp recurrence after surgical removal (respectively, P = .05 and P = .01).

Conclusions and Clinical Importance

The probability of recurrence of colorectal polyps in dogs is low, but increased in WHWTs and larger polyps, which might benefit from routine screening after removal. No effective predictors of polyp recurrence and survival were identified using the RVC.