bluuebunny/crossref_metadata_2025 huggingface dataset:
Kolon Poliplerinde WT1 Ekspresyonunun İncelenmesi
Authors: ASLAN Ali , ERDEM Havva , AKÇAY ÇELİK Mürüvvet , ŞAHİN Arzu , ÇANKAYA Soner
Published: February 2019

Amaç: WT1, ilk olarak Wilms tümörü gelişimini etkileyen tümör baskılayıcı bir gen olarak tespit edilmiş olsa da, kolon kanseri gibi bazı malignitelerde ekspresyonunun arttığı, dolayısıyla onkojenik özelliklerinin olduğu da bildirilmektedir. Bu çalışmanın amacı WT1 ekspresyonunun hastanın yaşına, cinsiyetine, örneğin alındığı bölgeye ve patolojik tanı türüne göre değişip değişmediğini tespit etmektir. Gereç ve Yöntemler: Patoloji anabilim dalına gönderilmiş kolon polipli 32 hastaya ait parafin blokların ve patoloji raporlarının retrospektif histopatolojik değerlendirilmesi yapılmıştır. İstatistiksel olarak p<0,05 anlamlı kabul edilmiştir. Bulgular: WT1 ekspresyonu ile hasta yaşı ortalaması, cinsiyet, lokalizasyon, çap, histopatolojik tanı parametreleri arasında istatistiksel olarak anlamlı ilişki izlenmedi (sırasıyla p=0,235; p=0,423; p=0,338; p=0,719; p=0,338). Bununla birlikte OR (odds ratio) değerleri dikkate alındığında ise klinik olarak anlamlı farklılıkların olduğu görüldü. Pozitif boyanma; adenomlarda (neoplastik grup) poliplere (non neoplastik grup) göre 4,308 kat (OR=4,308), transvers kolondan anüse kadar olan kısımda transvers kolona göre 4,308 kat (OR=4,308), ve kadınlarda erkeklere göre 2,333 kat (OR=2,333) daha yüksekti. Tartışma ve  Sonuç: Çalışmamızın bulguları poliplerde WT1 ekspresyonu ile cinsiyet, tanı ve biyopsinin alındığı yer arasında istatistiksel olarak anlamlı ilişki olmadığını, fakat OR değerleri dikkate alındığında klinik olarak anlamlı farklılıkların olduğunu düşündürmektedir. Rutin immünohistokimyasal inceleme ile WT1 ekspresyonu olan benign ve prekanseröz poliplerin tespiti, kolon tümörleri bakımından yüksek risk altındaki bireylerde WT1 immünoterapisinin ve aşı etkinliğinin daha iyi anlaşılmasına katkıda bulunabilir.
Malignant Melanoma Metastasizing to the Stomach
Authors: AKATA AKINCIOĞLU Talya , KÜÇÜK Ülkü , EKMEKÇİ Sümeyye , ABDULLAZADE Samir , YILDIZ Coşkun
Published: February 2019

Introduction:
Malignant melanoma (MM) can metastasise to nearly all organs of the human body.
Involvement of stomach is very rare.

Case report:
52-year-old female patient applied to our hospital with abdominal pain and
fatigue. Endoscopy revealed polypoid lesion in stomach.  Histopathologically, there were atypical
cells in lamina propria and brown pigment in some cells. These cells were
positive with Melan-A and HMB-45 and negative with Cytokeratin 7 and
Cytokeratin 20, immunohistochemically. This case was reported as “consistent
with MM”. We have reached to former pathology report of the enucleation
operation, with diagnosis of “MM with epithelioid features”. Tumor was
localised in the right bulbus oculi with pathological stage pT1a. Systemic scan
also revealed metastatic masses in liver.

Conclusion:
MM can simulate many other lesions clinically, endoscopically and
histopatholgically and must be keeped in mind all the time, especially in cases
with unknown primary. The patients should be screened for the primary tumor.
Gebelikte Beslenmenin Kordon Kanı Yağ Asidi Düzeylerine Etkisi
Authors: BÜYÜKUSLU Nihal , BİLGİ Zeynep Zehra , YOLDAŞ İLKTAÇ Havvanur , GARİPAĞAOĞLU Muazzez
Published: February 2019

Amaç: Çalışma
kordon kanı yağ asitleri üzerine gebelikte beslenmenin etkisini değerlendimek
amacıyla planlanmış ve yürütülmüştür. Gereç ve Yöntemler: 
Son trimesterin başında olan 33 gebeye ilişkin demografik özellikler ile
antropometrik ölçümler önceden hazırlanmış bir anket formu kullanırak alınmış,
24 saatlik besin tüketimleri kaydedilmiştir. Kordon kanlarının yağ asidi
içeriği, gaz kromatografisi yöntemiyle tespit edilmiştir. Günlük beslenme ile
alınan toplam yağ ve yağ asitleri, bilgisayarlı besin
analiz programı ile belirlenmiş, kordon kanı yüzde yağ asit düzeyleri
ile karşılaştırılmıştır. Bulgular: Gebelerin, günlük enerji alımları
ortalama 1894,37±590,46 kkal, enerjinin
karbonhidrat, protein ve yağ dağılımı sırasıyla; %40,7, %15,5, %43,8’tür.
Günlük beslenmedeki ve kordon kanındaki doymuş, tekli doymamış ve çoklu
doymamış yağ asitlerinin oranları sırasıyla: %39,7-%47,5, %38,6-%20,8,
%21,7-%32 olarak saptanmıştır. Sonuç: Beslenme ile alınan protein miktarının,
kordon kanı doymuş yağ asitleriyle ilişkili olduğu görülmüştür. Bu çalışmada
doymuş yağ ve protein içeriği yüksek beslenme alışkanlığının, kordon kanı
doymuş yağ asitleri düzeyini artırdığı görülmüştür. Gebe kadınların kendi sağlıklarını
korumak ve fetüsün normal gelişimini sağlamak için yeterli ve dengeli
beslenmeleri gerektiği ve bu konuda ileri çalışmalara ihtiyaç olduğu sonucuna
varılmıştır.
Efficacy of Extracorporeal Shock Wave Therapy in the Treatment of Achilles Tendinopathy: Clinical and Functional Outcomes
Authors: TURHAN Yalçın , ARICAN Mehmet , KARADUMAN Zekeriya Okan
Published: February 2019

Aim: Chronic Achilles tendinopathy (AT) is one of the most common tendon pathologies, and conservative treatment often fails to produce satisfactory results. This study aimed to investigate the efficacy of extracorporeal shock wave therapy (ESWT) in chronic and refractory AT.Materials and Methods: A total of 195 patients who had undergone ESWT for AT refractory to standard conservative treatment were assessed retrospectively, and 64 patients (64 feet) who met our eligibility criteria were included. The patients underwent three sessions of ESWT, each with 2000 pulses at a dose of 0.06–0.12 mJ/mm2 (low-dose). Pain levels and clinical/functional scores were measured before the treatment (BT) and at the 3rd and 12th weeks of the last session, by using the Visual Analogue Scale (VAS) and the American Orthopedic Foot and Ankle Society (AOFAS) scoring system.Results: Of the 64 patients included, 48 were female and 16 were male. The mean patient age was 47.9 years. There was improvement in pain, the mean VAS scores changing from 7.4 (5–10) BT to 4 (2–7) at week 3 (p<0.001) and 1.5 (0–6) at week 12 (p<0.001). The mean AOFAS scores were also improved, changing from 60 (48–75) BT to 74.8 (62–90) at week 3 (p<0.001) and 86.6 (62–100) at week 12 (p<0.001). There was no statistically significant difference between male and female patients with respect to the improvement recorded in the VAS scores (p=0.163). Discussion and Conclusion: Low-dose ESWT can produce successful clinical results in the treatment of chronic AT refractory to standard conservative treatment.
Network Pharmacology and Reverse Molecular Docking-Based Prediction of the Molecular Targets and Pathways for Avicularin Against Cancer
Authors: Duan Chaohui , Li Yang , Dong Xiaorui , Xu Weibin , Ma Yingli
Published: February 2019

Aim and Objective:

Avicularin has been found to inhibit the proliferation of HepG-2 cells in vitro in the screening of our laboratory. We intended to explain the molecular mechanism of this effect. Therefore, the combined methods of reverse molecular docking and network pharmacology were used in order to illuminate the molecular mechanisms for Avicularin against cancer.

Materials and Methods:

Potential targets associated with anti-tumor effects of Avicularin were screened by reverse molecular docking, then a protein database was established through constructing the drugprotein network from literature mining data, and the protein-protein network was built through an in-depth exploration of the relationships between the proteins, and then the network topology analysis was performed. Additionally, gene function and signaling pathways were analyzed by Go bio-enrichment and KEGG Pathway.

Results:

The result showed that Avicularin was closely related to 16 targets associated with cancer, and it may significantly influence the pro-survival signals in MAPK signaling pathway that can activate and regulate a series of cellular activities and participate in the regulation of cell proliferation, differentiation, transformation and apoptosis.

Conclusion:

The network pharmacology strategy used herein provided a powerful means for the mechanisms of action for bioactive ingredients.
Combinatorial Inhibition of mTORC2 and Hsp90 Leads to a Distinctly Effective Therapeutic Strategy in Malignant Pheochromocytoma
Authors: Zhang Xiaohua , Gao Fengbin , Zhong Shan
Published: February 2019

Background:

Malignant pheochromocytoma (mPCC) is an uncommon tumor with poor
prognosis, and no effective therapeutic strategy exists as yet. Discovering new and effective therapeutic
strategies to improve prognosis is an urgent need.

Objective:

To investigate whether a combinatorial inhibition of both mTORC2 and Hsp90 in PC12
cells could lead to a distinct anti-tumor effect in vitro and in vivo that was greater than the inhibition
of mTORC2 or Hsp90 alone.

Methods:

Targeting mTORC2 was assessed by knockdown of Rictor using shRNA, and 17-AAG
was used to inhibit Hsp90 function.

Results:

Combinatorial inhibition of both mTORC2 and Hsp90 could lead to a distinct anti-tumor
effect in vitro that was greater than the inhibition of mTORC2 or Hsp90 alone. Inhibiting Hsp90
specifically could inhibit tumor growth of sh-Rictor cells in vivo, suggesting that the combinatorial
inhibition of both mTORC2 and Hsp90 could lead to a distinct anti-tumor effect in vivo. Western
blotting has shown that both p-Akt Ser473 and p-Akt Thr450 showed significantly decreased expression
after targeting mTORC2, while p-Akt Thr308 did not. However, all three different p-AKTs,
including p-Akt Ser473, p-Akt Thr450 and p-Akt Thr308, showed a significantly decreased expression
in combinatorial inhibition of both mTORC2 and Hsp90. Collectively, it revealed that combinatorial
inhibition of mTORC2 and Hsp90 could destabilize the Akt signaling.

Conclusion:

Our results demonstrated that combinatorial inhibition of mTORC2 and Hsp90 could
increase their anti-tumor effect and destabilize the Akt signaling in PC12 cells, suggesting a combinatorial
inhibition of both mTORC2 and Hsp90 which might be an effective therapeutic strategy for
mPCC.
The Gut Microbiome, Lactobacillus acidophilus; Relation with Type 2 Diabetes Mellitus
Authors: Halawa Mohamed R. , El-Salam Mouchira Abd , Mostafa Bassem M. , Sallout Salma S.
Published: February 2019

Background:

Symbiotic interactions of microorganisms are widespread in nature, and support
fundamentally important processes linking health and disease to the bacterial ecology. Intestinal microbiota
is the largest source of microbial stimulation that exerts both harmful and beneficial effects on human
health. It participates in the development of the postnatal immune system as well as oral tolerance and
immunity. The recently explored impact of the microbiota on energy metabolism, gut hormone regulation
and the gut-brain axis was judged to be a fascinating topic and of great value in the future, and can have a
clinical role in the management of obesity and diabetes.

Objective:

To assess the impact of the gut microbe, Lactobacillus acidophilus, in patients with type 2
Diabetes Mellitus (controlled and uncontrolled) compared to healthy individuals, as a preliminary approach
to future treatment with probiotics, prebiotics or diet modulation.

Methods:

A case control study was conducted on 30 diabetic patients and 10 control individuals. All
patients were subjected to full history, thorough clinical examination, and laboratory measurement of
fasting blood sugar, 2 hours post prandial, Glycosylated Hemoglobin (HbA1C), CRP (C-Reactive Protein),
Lipid profile, and Identification of stool Lactobacillus acidophilus by PCR (polymerase chain reaction)
technique.

Results:

Significantly lower Stool Lactobacillus acidophilus PCR count among diabetic patients when
compared to healthy control individuals.

Conclusion:

Stool Lactobacillus acidophilus PCR count was lower among type 2 diabetic patients,
which may show relationship of lactobacillus with type 2 diabetes mellitus. However, further studies are
needed to determine correlation or causation of this relationship.
Structure-activity Relationship Study on Therapeutically Relevant EGFR Double Mutant Inhibitors
Authors: Fatima Shehnaz , Agarwal Subhash M.
Published: February 2019

Background:

EGFR is a clinically approved drug target in cancer. The first generation
tyrosine kinase inhibitors targeting L858R mutated EGFR are routinely used to treat non-small cell
lung cancer (NSCLC). However, the presence of a secondary mutation (T790M) tenders these inhibitors
ineffective and thus results in the relapse of the disease.

Objective:

New reversible inhibitors are required, which act against T790M/L858R (TMLR) double
mutants and overcome resistance.

Method:

In the present study, various Fragment based QSAR (G-QSAR) models along with
interaction terms have been studied for amino-pyrimidine derivatives having biological activity
against TMLR mutant enzyme.

Results:

The G-QSAR models developed using partial least squares regression via stepwise forward-
backward variable selection technique showed the best results. The model showed a high
correlation coefficient (r² = 0.86), cross-validation coefficient (q² = 0.81) and predicted correlation
(predicted r² = 0.62), which indicated that the model is robust and predictive. Based on the model,
it was revealed that at R1 position increasing saturated carbon (number of –CH atom connected
with 3 single bonds i.e. SsssCHcount) and retention index (chi3) is desired for the enhancement of
bioactivity. Additionally, at the R2 position, increasing lipophilic character (slogp) and at site R3,
the polarizability of compound need to be increased for better inhibitory activity. We further studied
the contribution of interactions among significant descriptors in enhancing the activity of the
compounds. It revealed that the presence of Sum((R1-SsssCHcount, R2-slogp) and Mult(R1-chi3,
R3-polarizabilityAHC) are the most significantly influencing descriptors. We further compared the
variation in the most and least active compounds which established that retention of the above
properties is essential for imparting significant inhibitory activity to these molecules.

Conclusion:

The study provides site specific information wherein chemical group variation
influences the inhibitory potency of TMLR amino-pyrimidine inhibitors, which can be used for
designing new molecules with the desired activity.
Design, Synthesis and Antiplasmodial Evaluation of Sulfoximine-triazole Hybrids as Potential Antimalarial Prototypes
Authors: Mabasa Tommy F. , Awe Babatunde , Laming Dustin , Kinfe Henok H.
Published: February 2019

Background:

Malaria, caused by the deadly Plasmodium falciparum strain, claims the lives of millions of people annually. The emergence of drug-resistant strains of P. falciparum to the artemisinin-based combination therapy (ACT), the last line of defense against malaria, is worrisome and urges for the development of new chemo-types with a new mode of action. In the search of new antimalarial agents, hybrids of triazoles and other known antimalarial drugs have been reported to possess better activity than either of the parent compounds administered individually. Despite their better activity, no hybrid antimalarial drugs have been developed so far.

Objective:

In the hope of developing new antimalarial prototypes, we propose the design, synthesis and antimalarial evaluation of novel sulfoximine-triazole hybrids owing to their interesting biological and physiological properties.

Methods:

The sulfoximine part of the hybrid will be synthesized via imidation of the corresponding sulfoxide. Propargylation of the NH moiety of the sulfoximine followed by copper-catalyzed click chemistry with benzyl azide was envisaged to provide the target sulfoximine-triazole hybrids.

Results:

Five novel sulfoximine-triazole hybrids possessing various substituents on the sulfoximine moiety have been successfully synthesized and evaluated for their antiplasmodial and cytotoxicity activities. The results revealed that the co-presence of the sulfoximine and triazole moieties along with a lipophilic alkyl substituent on the sulfur atom impart significant activity.

Conclusion:

Sulfoximine-triazole hybrids could be used as a prototype for the synthesis of new derivatives with better antiplasmodial activities.
Polyethylene Glycol Acts as a Mechanistic Stabilizer of L-asparaginase: A Computational Probing
Authors: Sindhu Rajashekar , Pradeep Hanumanthappa , Manonmani Haravey K.
Published: February 2019

Background:

L-asparaginase (L-ASN) is an anti-cancer enzyme therapeutic drug that
exerts cytotoxicity via inhibition of protein synthesis through depletion of L-asparagine in the tumor
microenvironment. The therapeutic performance of the native drug is partial due to the associated
instability, reduced half-life and immunogenic complications.

Objective:

In this study, we attempted the modification of recombinant L-asparaginase with PEG
and an integrated computational strategy to probe the PEGylation in the protein to understand the
biological stability/activity imparted by PEG.

Methods:

In vitro PEGylation of recombinant L-ASN was carried out and further evaluated in
silico.

Results:

PEGylation enhanced thermal and pH activities with extended serum half-life and resistance
to proteases compared to the native enzyme. The molecular dynamics analysis revealed intricate
interactions required in the coupling of PEG to L-asparaginase to bestow stronger binding affinity
of L-asparagine moiety towards L-asparaginase. PEG-asparagine complex ensured stable
conformation over both the native protein and asparagine-protein complex thus elucidating the
PEG-induced stable conformation in the protein. PEG mechanistically stabilized L-asparaginase
through inducing pocket modification at the receptor to adapt to the cavity.

Conclusion:

The study provides the rationale of PEGylation in imparting the stability towards Lasparaginase
which would expand the potential application of L-asparaginase enzyme for the effective
treatment of cancer.
Target Based Virtual Screening of New Leads Inhibitor against Bacterial Cell Division Protein FtsZ for the Discovery of Antibacterial Agents
Authors: Mishra Ratish C. , Kumari Rosy , Yadav Shivani , Yadav Jaya P.
Published: February 2019

Background:

Staphylococus epidermidis coagulase negative and gram positive streptococci have emerged as major nosocomial pathogens associated with the infection of implanted medical devices and dandruff on human scalp. S. epidermidis filamenting temperature-sensitive mutant Z (FtsZ) gene encoded FtsZ protein that assembles at future bacterial cell division site that forms Z-ring structure. FtsZ is a tubulin homolog protein with low sequence similarity; this makes it possible to inhibit bacterial FtsZ protein without affecting the eukaryote cell division.

Objective:

In the present study, phytochemicals of Cinnamomum zeylanicum, Punica granatum and Glycyrrhiza glabra were virtually screened for their antibacterial activity against Staphylococcus epidermidis cell division protein, FtsZ.

Methods:

Molecular docking method was used to investigate new lead inhibitor against bacterial cell division protein FtsZ. SwissADME and ProTox tool were used to evaluate the toxicity of the lead molecule.

Results:

Molecular docking based screening confirmed that among 122 phytochemicals, β- sitosterol and glabrol showed the highest inhibitory activity against FtsZ. SwissADME tool showed β-sitosterol and glabrol as the ideal antibacterial agents.

Conclusion:

Structure based drug design strategy has been broadly used to optimize antimicrobial activity of small molecule/ligand against large protein receptor of disease, causing pathogens which gives a major breakthrough in pharmaceuticals industries. The molecular docking and SwissADME tool showed that β-sitosterol and glabrol may be developed to be potential topical and sublingual antibacterial agents, respectively.
Novel 1,3,4-Triaryl Pyrazoles: Synthesis, QSAR Studies and Cytotoxicity against Breast Cancer
Authors: Ismail Magda M.F. , Farrag Amel M. , Harras Marwa F.
Published: February 2019

Background:

The existence of drug-resistance and lack of selectivity encourages scientists to search for novel and more selective cytotoxic agents.

Objective:

In this work, novel 1,3,4-triarylpyrazole derivatives were synthesized to study their cytotoxicity on MCF7 (human breast Cell Line). In addition, QSAR studies were performed to show the relation between the cytotoxic activity and the structural features of our new synthesized pyrazole derivatives.

Methods:

Pyrazole-4-carbaldehyde derivative 3 was utilized as a starting material for the preparation of the new pyarazole derivatives. These target compounds were screened for their cytotoxic activity against MCF-7 followed by study cell cycle of the most active compounds. Finally, pharmacophore modeling and QSAR Studies was carried out.

Results:

Among these compounds; 5d and 8b showed the highest anti-proliferative activity (IC50 = 4.9 and 2.11 µM, respectively). Flow cytometric analysis showed that, compounds 5d and 8b arrested the cell cycle in addition to induction of apoptosis in MCF7 cells. Moreover, their stimulation effect on caspases 3/7 was examined to explore their mechanism of induction of apoptosis and the results showed that their proapoptotic activity could be due to the activation of caspases 3/7.

Conclusion:

Pyrazole derivatives 5d and 8b displayed potent bioactivities, indicating that these compounds could be considered as a new lead for more investigation in the future
Biomarkers of Osteoporosis: An Update
Authors: Parveen Bushra , Parveen Abida , Vohora Divya
Published: February 2019

Background:

Osteoporosis, characterized by compromised bone quality and strength is
associated with bone fragility and fracture risk. Biomarkers are crucial for the diagnosis or prognosis
of a disease as well as elucidating the mechanism of drug action and improve decision making.

Objective:

An exhaustive description of traditional markers including bone mineral density, vitamin D,
alkaline phosphatase, along with potential markers such as microarchitectural determination, trabecular
bone score, osteocalcin, etc. is provided in the current piece of work. This review provides insight into
novel pathways such as the Wnt signaling pathway, neuro-osseous control, adipogenic hormonal imbalance,
gut-bone axis, genetic markers and the role of inflammation that has been recently implicated
in osteoporosis.

Methods:

We extensively reviewed articles from the following databases: PubMed, Medline and Science
direct. The primary search was conducted using a combination of the following keywords: osteoporosis,
bone, biomarkers, bone turnover markers, diagnosis, density, architecture, genetics, inflammation.

Conclusion:

Early diagnosis and intervention delay the development of disease and improve treatment
outcome. Therefore, probing for novel biomarkers that are able to recognize people at high risk for
developing osteoporosis is an effective way to improve the quality of life of patients and to understand
the pathomechanism of the disease in a better way.
Elucidation of the Chemopreventive Role of Stigmasterol Against Jab1 in Gall Bladder Carcinoma
Authors: Pandey Pratibha , Bajpai Preeti , Siddiqui Mohammad H. , Sayyed Uzma , Tiwari Rohit , Shekh Rafia , Mishra Kumudesh , Kapoor V.K.
Published: February 2019

Background:

Plant sterols have proven a potent anti-proliferative and apoptosis inducing agent against several carcinomas including breast and prostate cancers. Jab1 has been reported to be involved in the progression of numerous carcinomas. However, antiproliferative effects of sterols against Jab1 in gall bladder cancer have not been explored yet.

Objective:

In the current study, we elucidated the mechanism of action of stigmasterol regarding apoptosis induction mediated via downregulation of Jab1 protein in human gall bladder cancer cells.

Methods:

In our study, we performed MTT and Trypan blue assay to assess the effect of stigmasterol on cell proliferation. In addition, RT-PCR and western blotting were performed to identify the effect of stigmasterol on Jab1 and p27 expression in human gall bladder cancer cells. We further performed cell cycle, Caspase-3, Hoechst and FITC-Annexin V analysis, to confirm the apoptosis induction in stigmasterol treated human gall bladder cancer cells.

Results:

Our results clearly indicated that stigmasterol has up-regulated the p27 expression and down-regulated Jab1 gene. These modulations of genes might occur via mitochondrial apoptosis signaling pathway. Caspase-3 gets activated with the apoptotic induction. Increase in apoptotic cells and DNA were confirmed through annexin V staining, Hoechst staining, and cell cycle analysis.

Conclusion:

Thus, these results strongly suggest that stigmasterol has the potential to be considered as an anticancerous therapeutic agent against Jab1 in gall bladder cancer.
Pengiriman Tenaga Perawat dan Careworker Indonesia ke Jepang dalam Kerangka Indonesia - Japan Economic Partnership Agreement (IJ-EPA)
Authors: Aminah Shobichatul , Wardoyo Stedi , Pangastoeti Sri
Published: February 2019

Due to the shortage of professional workers in various felds, Japan began to open up a wide opportunity for the entry of foreign workers by opening various cooperation with other countries to invite the workers to their country. One of them is with Indonesia through a cooperation scheme called IJ-EPA (Indonesia - Japan Economic Partnership Agreement) which includes cooperation in the procurement of manpower feld of nursing. Delivery of nursing workers to Japan certainly has some obstacles, especially related to the complicated requirements to become a nursing staﬀ in Japan, the abilitym to master Japanese and Japanese culture. Terefore, a team of a community engagement of Prodi Jepang, FIB, UGM seeks to help reduce these obstacles through the Socialization of Nurse Competency Standards in the IJ-EPA Framework. Te event was held on 22 November 2017 at Bahrul Ulum Medical School (STIKES), Tambakberas, Jombang, East Java. Te materials given are information about competency standards as required in IJ-EPA, Japanese social and cultural conditions, as well as gemba nihongo or Japanese language used in the nursing profession.
Tanduk Alit
Authors: Budaya Bakti
Published: February 2019

Rubrik suplemen yang berisi ringkasan laporan dan output hasil kegiatan pengabdiankepada masyarakat .
Hubungan antara Kecerdasan Emosi dengan Koping pada Gamer
Authors: Tahali Ummaimah Insyirah , Purnamaningsih Esti Hayu
Published: February 2019

There are numerous studies about the relationship between emotional intelligence and coping stress. However, there’s still a few studies that examined the relationship of those two in gamer. Hence, the aimed of this study is to empirically examined the relationship between emotional intelligence and coping stress in gamer. The hypothesis of this study stated that there was a relationship between emotional intelligence and coping stress. Participants of the study were 101 college students who is played video game with age range from 17 to 25. Product moment technique was used to analyze the data. The result of the study showed that there is a significant and positive relationship between emotional intelligence and coping stress (p < 0,001; r = 0,586). Based on this result, the hypothesis was accepted.
PHARMACOGNOSTICAL AND PHYSICOCHEMICAL ANALYSIS OF TODDALIA ASIATICA (L.) LAM. RUTACEAE
Authors: Bangajavalli S.
Published: February 2019

Objective: To characterize macroscopical and microscopical features of the leaf and stem of Toddalia asiatica (L.) Lam. RUTACEAE. Explore and establish the micro-morphology and quality control methods for this plant.Methods: leaves and stem ofÂ Toddalia asiatica (L.) Lam. wereÂ collected for Pharmacognostic studies involving macros, microscopic evaluation and physicochemical parameters analysis like Ash value, Moisture content, Fluorescence analysis and phytochemicals.Results: The leaf even and smooth on the adaxial side and highly undulate and densely hairy on the abaxial side. The midrib is very thick projecting much below the lower side of the leaf. The midrib is slightly revised above the adaxial side. It is thick and semicircular on the abaxial side. It is 950 Âµm thick and 900 Âµm wide. The lateral vein hangs from the abaxial surface of the lamina. It is thick and prominent. There is no distinct differentiation of palisade and spongy mesophyll tissue. The lamina is 100 Âµm thick. In the region of lateral veins, it is 160 Âµm thick. Calcium oxalate crystals are fairly abundant in the secondary xylem parenchyma cells of the stem. Prismatic crystals also sparsly seen in the parenchyma cells outside the gelatinous fibre. The powder was also treated with different chemical reagents and changes in colour were studied in ordinary light and UV light. These fluorescence characters were determined according to the methods of Chase and Pratt. The total moisture content of the Toddalia asiatica was 46%. The total ash content of the whole plant was found 96%, the acid insoluble ash content of the whole plant was found 5%, the water-soluble ash content of the whole plant was found 2%, and the sulphated ash content of the whole plant was found 85%. The extractive values obtained from different solvents were found in the Toddalia asiatica among all the extracts chloroform showed the highest percentage (81%) followed by Ethanol (45%) and Benzene (44%). The distribution of different phytochemical constitutes in ethanol, benzene, chloroform acetone, petroleum ether and water of whole plant powder was evaluated qualitatively. The phytochemical such as carbohydrates, saponins, flavonoid, alkaloids, cardiac glycosides, phenols, coumarins, and steroids have been confirmed in the all the above extracts of the selected plant. Moreover, phytochemicals such as alkaloids, flavonoid, cardiac glycosides, courmarins, and steroids are also present in the sample and absence of, anthraquinone, steroid, terpenoid and fixed oil.Conclusion: The observations confirmed thatÂ Toddalia asiatica obvious Pharmacognostic characteristics, which will be useful towards providing a reliable basis for identification, purity, quality, and classification of the plant. Results shall pave a way in the standardization of the drug.
COMPARISON OF AMINO ACIDS IN 8 DIFFERENT BOILED TROPICAL FRUITS
Authors: Palaniswamy Radha , Selvaraj Dhanyasri , Renganathan Sandhiya
Published: February 2019

Objective: To determine the protein quality, especially the amino acid content of 8 tropical fruits both raw and boiled samples. Eight different tropical fruits were used in the study (Apricot, Jamun, Dragonfruit, Pomegranate, Mangustan, Litchi, Jackfruit, and Kiwi.Methods: Ninhydrin method was used for the estimation of the concentration of amino acids present in the above fruits. Raw and boiled fruits were used for the study.Results: Both raw and boiled forms which showed thats Jamun and Mangustan contained highest concentration amino acids whereas apricot shows the lowest concentration of amino acids except in Jamun which showed higher values in the raw fruit whereas in others the boiled samples showed higher values.Conclusion: It was evident that tropical fruits have a good balance of the essential amino acids (both raw and boiled fomr) which provide significant sources of protein in our diet.
Los dispositivos móviles como apoyo al proceso de enseñanza-aprendizaje
Authors: Díaz Barahona María Edith , Tec Montañezz Idalia Jisela
Published: February 2019

En el siguiente trabajo, se describe a m-learning como una metodología que permite utilizar la tecnología móvil para el aprendizaje ubicuo mediante el uso, tanto de aplicaciones diseñadas expresamente para la educación como de aquéllas que este ámbito puede emplear en aras de un mejor proceso de enseñanza-aprendizaje; además, se analizan las ventajas y desventajas de su implementación; también se describe las competencias que debe desarrollar el docente y el rol que debe asumir para trabajar con las generaciones actuales que demandan dinámicas de aprendizaje diferentes; se destaca al constructivismo como punto de partida para explicar el aprendizaje mediante el uso de tecnología móvil y la autonomía que adquiere el estudiante bajo esta metodología; por último, se analizan algunas oportunidades del uso de dispositivos móviles en el Bachillerato en Línea de la UADY.
Atención a deportistas de alto rendimiento: la experiencia de acompañamiento en Cantera-Pumas UNAM
Authors: Carranza Georgina G.
Published: February 2019

En el Bachillerato a Distancia de la UNAM se ha trabajado por incluir a diversas poblaciones para que tengan la oportunidad de continuar sus estudios de educación media superior de manera simultánea con su proyecto de vida deportivo. Por ello, de abril de 2017 a junio de 2018, se han abierto tres generaciones en Cantera Pumas. Estos jóvenes enfrentan retos que implican los tiempos de dedicación, ya que viajan constantemente a torneos y entrenan varias horas del día; al respecto, las intervenciones de tutoría representan un papel fundamental, así como lo es también el trabajo interdisciplinario con las figuras que son parte de este proyecto. Durante el tiempo que se ha realizado esta atención se ha percibido que los jóvenes son entusiastas, optimistas y perseverantes; además, permiten que se les apoye y han logrado desarrollar habilidades como la organización de tiempo y la autorregulación.
Estrategia de enseñanza para profesores con discapacidad auditiva en la modalidad en línea
Authors: Gaillard Rivero Iván
Published: February 2019

El presente documento tiene como objetivo dar a conocer una serie de contenidos y herramientas que faciliten el proceso de enseñanza-aprendizaje entre el profesor con discapacidad auditiva y el alumnado en la educación virtual, teniendo en cuenta la heterogeneidad de sus necesidades. Lo anterior conlleva una adaptación continua a las estrategias de enseñanza.

La comunicación, ya sea verbal o no, es la herramienta fundamental para relacionarnos. En el caso del profesor con discapacidad auditiva, resulta importante que se emplee un sistema comunicativo adecuado y se faciliten espacios de relación, así como la adquisición de un código de comunicación útil en línea.
En este artículo se recogen las diferentes estrategias de comunicación que los profesores con discapacidad auditiva pueden aportar como ejercicio en el aula virtual, además de los recursos didácticos y una lista de conocimientos útiles, sencillos y prácticos para no dificultar su labor con los alumnos. Asimismo, se pretende recoger la diversidad de necesidades y características de los profesores con discapacidad auditiva en la educación virtual, partiendo de un rasgo común: las barreras de comunicación.
Edición de la RMBD, allende el trabajo de publicación
Authors: Vilchis Ortega Natzi
Published: February 2019

En este artículo, describo los aprendizajes obtenidos en materia de educación a distancia a partir de mi experiencia como editora de la RMBD. De igual forma, reflexiono sobre la importancia de cada uno de los actores de este sistema educativo y cómo es que los avances logrados durante los últimos diez años han quedado registrados en los veinte números de la revista. De manera paralela, se describe el trabajo de edición en cada una de las etapas que conforman el proceso editorial de la RMBD: recepción de materiales, dictaminación, cuidado editorial, diseño y publicación.
La RMBD como un diálogo entre los teóricos de la educación a distancia en tres de sus secciones: “Presencia de la IRRODL en la RMBD”, “Artículo por invitación” y “Visión internacional”: una reseña
Authors: González Villatoro María Teresa
Published: February 2019

La RMBD ofrece la oportunidad de compartir tanto experiencias de los programas educativos en México como los resultados y reflexiones generadas en otros ámbitos, siendo su foco la búsqueda constante de mejora en la calidad de la educación a distancia. El presente trabajo pretende, a través de tres temas (recursos de apoyo al aprendizaje, docentes en ambientes virtuales y reflexiones teóricas), generar un diálogo entre los autores participantes en tres secciones de la revista. Las diferencias y similitudes encontradas en los trabajos permitieron profundizar en las aportaciones de cada uno, además de que se constituyeron como el punto de partida para dar cuenta de algunas tendencias de las temáticas abordadas.
Introducción a los fenómenos ópticos de nanopartículas metálicas a través simulaciones computacionales en línea
Authors: Garate Octavio Federico
Published: February 2019

Al introducir las propiedades dependientes del tamaño de los nanomateriales, uno de los tópicos más atractivos lo constituyen las propiedades ópticas de las nanopartículas, debido al impacto inmediato que generan sobre el observador. No obstante, por lo general no resulta posible introducir un tratamiento riguroso de los fenómenos de absorción y dispersión de luz, debido al complejo marco teórico asociado a las interacciones entre la radiación electromagnética y las nanopartículas. Utilizando una herramienta de simulación en línea como Nmie-Nanohub, se propone una secuencia pedagógica que permita analizar la dependencia de estos fenómenos ópticos con los parámetros relevantes, tales como la longitud de onda de la radiación incidente, el tamaño y material de las nanopartículas, y el medio en el cual se encuentran inmersas.
La Industria Nacional Químico-Farmacéutica, S.A. de C.V. y P.E. (1949-1964). Un modelo sobresaliente de organización científica y empresarial.
Authors: Godínez Reséndiz Rogelio , Aceves Pastrana Patricia , Schifter Aceves Liliana
Published: February 2019

En 1949, fue fundada la primera empresa mexicana de participación estatal dedicada a la fabricación de medicamentos, la Industria Nacional Químico-Farmacéutica, S.A. de C.V. y P.E. (INQFA). Constituida a partir de compañías extranjeras confiscadas durante la Segunda Guerra Mundial, la INQFA fue una de las primeras corporaciones en realizar síntesis orgánica de moléculas terapéuticas en territorio nacional. De igual forma, en ella trabajaron químicos mexicanos y extranjeros de renombre dedicados a diferentes ramas, convirtiéndola en una de las empresas farmacéuticas más importantes de la época. El objetivo de este artículo es analizar los factores que intervinieron en la creación, desarrollo y desmantelamiento de la INQFA, como un modelo sobresaliente de organización empresarial y científica dirigido a estudiantes y profesionales de las ciencias químico-farmacéuticas.
Extracción de ADN con material cotidiano: diseño, implementación y validación de una intervención activa interdisciplinar
Authors: Gómez Ochoa de Alda Jesús , Esteban Gallego Rocío , Marcos-Merino José María
Published: February 2019

Las prácticas tradicionales de ciencias, basadas en seguir instrucciones cerradas, no proporcionan resultados de aprendizaje satisfactorios. Esto se debe, en parte, a que no tienen una aplicación inmediata, carecen de una perspectiva interdisciplinar y el alumno no desarrolla un papel activo en su resolución. Una alternativa es su planteamiento como pequeñas investigaciones en las que los alumnos desarrollan su propio guion a través de preguntas elaboradas por el docente. Con el fin de aumentar el número de propuestas de prácticas activas, en este trabajo se describe y valida una intervención didáctica, la extracción de ADN con material cotidiano, centrada en el aprendizaje activo interdisciplinar. Esta práctica es muy atractiva para los alumnos de educación secundaria, bachiller o maestros en formación ya que, al desarrollarse bajo investigación dirigida, hace que los estudiantes participen en la búsqueda, interpretación y utilización de algunos fundamentos científicos de Química, Física y Biología. El análisis de la efectividad de la implementación de esta intervención durante 3 cursos académicos muestra que esta favorece el aprendizaje interdisciplinar. 
Editorial
Authors: Martínez Vázquez Ana María
Published: February 2019

Comenzamos el año con el entusiasmo acostumbrado, y celebrando como es la tradición al premio Nobel de Química recién otorgado. En esta ocasión los galardonados fueron dos hombres y una mujer. Para platicarnos sobre la importancia del tema contamos con la participación de la Dra. Gloria Saab, investigadora del Instituto de Biotecnología de la Universidad Nacional Autónoma de México. Ella sabe muy bien el trabajo de Frances Arnold, e incluso la conoce a ella en persona porque vivió una estancia sabática en su laboratorio.
Allen E. Buchanan y Dan W. Brock, Decidir por otros. Ética de la toma de decisiones subrogada
Authors: Álvarez del Río Asunción
Published: February 2019

Las reseñas no incluyen resumen.
Roflumilast does not decrease COPD exacerbations in adequately treated patients, but subgroup analysis allows for shared decision making
Authors: Sanchez Nathanael
Published: February 2019

A critical appraisal and clinical application of Martinez FJ, Rabe KF, Sethi S, et al. Effect of Roflumilast and Inhaled Corticosteroid/Long-Acting beta2-Agonist on Chronic Obstructive Pulmonary Disease Exacerbations (RE(2)SPOND). A Randomized Clinical Trial. Am J Respir Crit Care Med. Sep 1 2016;194(5):559-567. doi: 10.1164/rccm.201607-1349OC.
NPO or AMA? Patients allowed clear liquids up to 2 hours pre-procedure have equivalent aspiration risk and increased patient satisfaction
Authors: Smith Erich
Published: February 2019

A critical appraisal and clinical application of Itou K, Fukuyama T, Sasabuchi Y, et al. Safety and efficacy of oral rehydration therapy until 2 h before surgery: a multicenter randomized controlled trial. Journal of Anesthesia. 2012;26(1):20-27. doi: 10.1007/s00540-011-1261-x.
Gentrification, creative class and problems of conflict of interest in contemporary urban development
Authors: Kostic Vladimir , Kostic Aleksandar , Dinic-Brankovic Milena
Published: February 2019

This paper considers modern city territories and analyzes neoliberal spatial
city planning which is, among other things, mostly realized through
gentrification. While explaining the modern transformation tendencies of
cities the authors seek to find the link between the gentrification
phenomenon and the rise of city inequality. In this context, marginality is
not the result of economic underdevelopment but economic progress. The paper
explores the reasons why contemporary urban politics leads to class
segregation. The authors investigate a genetic connection of the capital and
urbanization confirming Harvey?s paradigm that ?capitalism is forced to
urbanize in order to renew itself?. Furthermore, the paper investigates the
relationship between creative class-creative city and to what extent it is
reality and to what ?a utopia for the chosen ones.?
Development of a computer program for the design of laterally unrestrained steel beams
Authors: Olalusi Oladimeji , Dirisu Tony , Arum Chinwuba
Published: February 2019

This study presents the design results of a C-sharp based computer program
developed for the design of laterally unrestrained I-section steel beams.
The program was developed based on the stipulations of BS 5950 and Eurocode
3 (EC3) design standards. Several sets of steel beam models having the same
cross-sectional dimensions but different laterally unrestrained span
lengths, were designed using the developed program, and the results were
validated using an established software, Staad Pro. The design results
obtained were found similar to the results obtained using Staad Pro. For a
specific beam section with constant loadings, as the span length of the
laterally unrestrained compression flange increases the buckling capacity
reduces, thus the longer the beam, the more it is susceptible to lateral
torsional buckling. Comparison of the results obtained using BS 5950 to
those of EC 3 at different laterally unrestrained span lengths revealed that
the areas of design sections obtained for BS 5950 are 21.5%, on the average,
higher than those of EC3. Thus, beams with laterally unrestrained
compression flange designed according to the requirements of EC 3 are more
economical. The difference in results is because of the differences in the
principles of design and measures used between the two standards.
Curing: The easiest and cheapest method to increase the durability and strength of concrete
Authors: Rath Badrinarayan , Deo Shirish , Ramtekkar Gangadhar
Published: February 2019

Curing is a process which follows immediately after placing and finishing of
concrete. It maintains a satisfactory moisture content and temperature in
concrete for a period of time so that the desired properties may develop.
Curing has a strong influence on the properties of hardened concrete. With
proper curing concrete becomes stronger, more impermeable, and more
resistant to stress, abrasion, and freezing and thawing. Using of fiber in
concrete may improve these properties but it increases the cost of concrete.
This paper reports the results of a study conducted to assess the effect of
ages of curing on durability and strength of fiber and non fiber reinforced
concrete. Also a comparative study of cost per unit strength and cost per
unit service life period is done in between fiber reinforced concrete and
non fiber reinforced concrete with proper curing. The concrete cubes were
prepared by varying three water cement ratios and by curing them for a
different number of curing days. Bulk electrical resistivity test,
ultrasonic pulse velocity test, compressive strength test, flexural strength
test and carbonation depth test of the cured cubes were performed. From the
test results it is found that proper curing of traditional concrete is more
economical than fiber reinforced concrete in achieving the same strength and
durability.
Electrophoretic deposition as an effective and simple processing technique for fabrication of magnesium silicate hydrate (M-S-H) coatings onto stainless steel substrates
Authors: Randjelovic Marjan , Covic Jelena , Zarubica Aleksandra , Bojic Aleksandar
Published: February 2019

Magnesium silicate hydrate (M-S-H) was prepared via one-pot hydrothermal
synthesis and electrophoretically deposited (EPD) onto stainless steel
substrate (Type 304), varying different process parameters. The optimal
conditions for the EPD process were found to be as follows. A stable
suspension of material was achieved using isopropanol containing 1% water as
dispersing medium and Mg-nitrate as charging additive. The best coating was
obtained after three successively repeated EPD processes at a voltage of 30
V, accompanied by drying at room temperature between each EPD cycle. The
coating showed a thickness of 31 ?m and very smooth surface. After
calcination at 900?C coating retains its adherence to the substrate but
undergoes a structural transformation from poorly crystallized M-S-H to
well-crystallized clinoenstatite phase which is known for its
biocompatibility. As a result, it densifies and shrinks giving grainy and
slightly rough surface. Structural properties and parameters of the
magnesium silicate hydrate (M-S-H) and clinoenstatite were acquired by XRD
technique, while morphology was examined by the analysis of SEM micrographs.
This study demonstrates that: i) M-S-H can be synthesized through simple
hydrothermal route starting from simple, low-cost precursors, ii) EPD
process is an effective technique for deposition of M-S-H materials onto
stainless steel and iii) inosilicate mineral (clinoenstatite) can be
successfully obtained from M-S-H by calcination at 900?C.