bluuebunny/crossref_metadata_2025 huggingface dataset:
Recent Developments in Targeting Bromodomain and Extra Terminal
Domain Proteins for Cancer Therapeutics
Authors: Cai Maohua , Dong Jinyun , Li Haobin , Qin Jiang-Jiang
Published: February 2022

Bromodomain and extra-terminal domain (BET) proteins are a well-studied
family of proteins associated with a variety of diseases, including malignancy and chronic
inflammation. Currently, numerous pan BET inhibitors have exhibited potent efficacy
in several in vivo preclinical models and entered clinical trials but have largely stalled
due to their adverse events. Therefore, the development of new selective inhibitors and
PROTACs (Proteolysis Targeting Chimeras) targeting BET is urgently needed. In the present
review, we summarize the BET protein structure and the recent development in BET
inhibitors, focusing mainly on BRD4-selective inhibitors and PROTAC degraders.
The Complete Chloroplast Genome Sequence of Cicer bijugum, Genome
Organization, and Comparison with Related Species
Authors: Temel Melih , Kaymaz Yasin , Ateş Duygu , Kahraman Abdullah , Tanyolaç Muhammed Bahattin
Published: February 2022

Background:

Chickpea is one of the legumes that is very important for Turkey and is frequently preferred especially in human nourishment thanks to its rich nutritional content. Chloroplasts, which have their own genetic material, are organelles responsible for photosynthesis in plant cells and their genome contains non-trivial information about the molecular features and evolutionary process of plants.

Objective:

Current study aimed at revealing complete chloroplast genome sequence of one of the wild type Cicer species Cicer bijugum and comparing its genome with cultivated Cicer species Cicer arietinum by using bioinformatics analysis tools. There are no study about revealing chloroplast genome sequence of Cicer species except the cultivated one Cicer arietinum. Therefore, we targeted to reveal the complete chloroplast genome sequence of wild type Cicer species Cicer bijugum and compare the chloroplast genome of Cicer bijugum with the cultivated one Cicer arietinum.

Methods:

In this study, we sequenced the whole chloroplast genome of Cicer bijugum, one of the wild types of chickpea species, with the help Next Generation Sequencing platform and compared it with the chloroplast genome of the cultivated chickpea species, Cicer arietinum by using online bioinformatics analysis tools.

Results:

We determined the size of the chloroplast genome of C. bijugum as 124,804 bp and found that C. bijugum did not contain an inverted repeat region in its chloroplast genome. Comparative analysis of the C. bijugum chloroplast genome uncovered thirteen hotspot regions (psbA, matK, rpoB, rpoC1, rpoC2, psbI, psbK, accD, rps19, ycf2, ycf1, rps15 and ndhF) and seven of them (matK, accD, rps19, ycf1, ycf2, rps15 and ndhF) could potentially be used as strong molecular markers for species identification. It has been determined that C. bijugum was phylogenetically closer to cultivated chickpea as compared to the other species.

Conclusion:

It is aimed that the data obtained from this study, which is the first study in which whole chloroplast genomes of wild chickpea species were sequenced, will guide researchers in future molecular, evolutionary and genetic engineering studies with chickpea species.
Combined Marangoni and Buoyancy Convection in a Porous Annular Cavity Filled with Ag-MgO/Water Hybrid Nanofluid
Authors: Al-Mdallal Qasem M. , Kanimozhi B. , Muthtamilselvan M. , Abdalla Bahaaeldin
Published: February 2022

Background:

This article numerically examines the effect of buoyancy and Marangoni
convection in a porous enclosure formed by two concentric cylinders filled with Ag-MgO water hybrid
nanofluid. The inner wall of the cavity is maintained at a hot temperature, and the outer vertical
wall is considered to be cold. The adiabatic condition is assumed for the other two boundaries. The
effect of the magnetic field is considered in radial and axial directions. The Brinkman-extended Darcy
model has been adopted in the governing equations.

Methods:

The finite difference scheme is employed to work out the governing Navier-Stokes equations.
The numerically simulated outputs are deliberated in terms of isotherms, streamlines, velocityand
average Nusselt number profiles for numerous governing parameters.

Results:

Except for a greater magnitude of axial magnetic field, our results suggest that the rate of
thermal transport accelerates as the nanoparticle volume fraction grows. Also, it is observed that
there is an escalation in the profile of average Nusselt numberwith an enhancement in Marangoni
number.

Conclusion:

Furthermore, the suppression of heat and fluid flow in the tall annulus is mainly due to
the radial magnetic field whereas in the shallow annulus, the axial magnetic field profoundly affects
the flow field and thermal transfer.
Hematopoietic Stem Cells Characteristics: From Isolation to Transplantation
Authors: Fathi Ezzatollah , Ehsani Ali , Sanaat Zohreh , Vandghanooni Somayeh , Farahzadi Raheleh , Montazersaheb Soheila
Published: February 2022

Hematopoietic stem cells (HSCs) have self-renewal as well as pluripotency properties and are
responsible for producing all types of blood cells. These cells are generated during embryonic development
and transit through various anatomical niches (bone marrow microenvironment). Today, they are
easily enriched from some sources, including peripheral blood, bone marrow, and umbilical cord blood
(UCB). HSCs have been used for many years to treat a variety of cancers and blood disorders such as
various types of leukemia, lymphoma, myelodysplastic, myeloproliferative syndromes, etc. Although
almost 50 years have passed since the discovery of stem cells and numerous investigations on cell therapy
and regenerative medicine have been made, further studies need to be conducted in this regard. This manuscript
review the history, location, evolution, isolation, and therapeutic approaches of HSCs.
Electron Communications and Correlations in Subsystems
Authors: Nalewajski Roman F.
Published: February 2022

The quantum entanglement of molecular fragments in reactive systems is approached.
The "external" (inter-fragment) and “internal” (intra-fragment) correlation energies
are expressed in terms of the DFT average correlation holes resulting from the coupling
constant integration of the scaled electron repulsion terms in the electronic Hamiltonian. Information
networks in the local and configuration resolutions are examined, and their conditional
entropy (covalency) and mutual information (iconicity) descriptors are summarized.
The local channels in the single Slater determinant approximation of HF theory are explored
in some detail. The multisite events in the bond system for the specified molecular state are
tackled, cascade (bridge) propagations are examined, and the Fermi (exchange) correlation
of HF theory is discussed. The partial density matrices of interacting fragments are introduced,
and their role in shaping the ensemble averages of physical observables and effective
communications within reactants is examined.
Polyelectrolyte-Surfactant Mixtures as the Model for Understanding the Performance of 2-in-1 Shampoo Formulations
Authors: Guzmán Eduardo
Published: February 2022

Background:

2-in-1 shampoos are very complex multi-component mixtures used for the cleansing of the hair fibers and the modulation of their tribological properties, contrib-uting to the reduction of the negative charge of damaged hair fibers. This is the result of the combined action of the polyelectrolytes and surfactants that play a central role in the effec-tiveness of modern 2-in-1 shampoo formulations. Thus, surfactants contribute to the removal of the dust and fatty compounds during the washing process, whereas polyelectrolytes present a strong ability to be deposited on the surface of damaged fibers, and enhance their tribologi-cal properties. However, the lack of knowledge about the main forces driving the conditioning process has pushed the research and development strategy of the cosmetic industry towards the design of state-of-the-art experimental and theoretical methodologies for evaluating the behavior of mixtures formed by polyelectrolytes and surfactants in solution and adsorbed onto solid surfaces with a negative charge and contact angle for water similar to those appearing in the surface of damaged hair fibers, which have become a very promising tool for obtaining important insights that can be exploited for the optimization of new formulations for hair cleaning and conditioning.

Aims:

This work tries to provide an updated perspective of the current understanding of the behavior of mixtures containing polyelectrolytes and surfactants bearing opposite charges in relation to their performance in hair care and conditioning for providing a link between physi-co-chemical aspects and the performance of real 2-in-1 formulations.

Conclusions:

The study of polyelectrolyte-surfactant mixtures is a powerful tools for obtaining useful information for the optimization of cosmetic formulations for hair care and condition-ing. However, the rational design of this type of cosmetic products must be considered a mul-ti-disciplinary challenge, which requires the combined efforts of researchers with very differ-ent backgrounds.
IL-6, IL-1β, and MDA Correlate with Thrombolysis in Myocardial Infarction
(TIMI) Risk Score in Patients with Acute Coronary Syndrome
Authors: de Paula da Silva Marcus V. , Villar-Delfino Pedro Henrique , Nogueira-Machado José A. , Volpe Caroline M.O.
Published: February 2022

Background:

Inflammation plays a significant role in the pathophysiology of Acute
Coronary Syndrome (ACS) but is not included in current risk stratification.

Objective:

This study aimed at determining the association between thrombolysis in Myocardial Infarction
(TIMI) risk score and inflammatory biomarkers in the ACS, including unstable angina
(UA), non-ST segment elevation myocardial infarction (NSTEMI), and ST-segment elevation myocardial
infarction (STEMI). We hypothesized that inflammatory biomarkers could add prognostic
value to the TIMI risk score.

Methods:

In this cross-sectional study, serum levels of interleukins (IL)-6 and IL-1β and MDA
(malondialdehyde) were quantified by ELISA and colorimetry, respectively, of patients with ACS
(n = 48; 31.3 % with UA, 33.3 % with NSTEMI, and 35.4 % with STEMI) and healthy controls (n
= 43). We assessed the TIMI scores in the first 24 h after symptom onset.

Results:

The results showed that patients with ACS had significantly higher levels (p<0.05) of the
inflammatory biomarkers IL-6, IL-1β, and MDA than the control group. However, we found no significant
differences in IL-6, IL-1β, and MDA levels among the patients with ACS according to
their classification as UA, NSTEMI, and STEMI. Positive correlations were observed between TIMI
and IL-6 (r=0.68), IL-1β (r= 0.53), and MDA (r=0.58) in patients with UA and between TIMI
and IL-1β (r= 0.62) in STEMI patients.

Conclusion:

These data suggested the presence of a pro-inflammatory profile in patients with ACS
as well as positive correlations between TIMI scores and the inflammatory biomarkers IL-6, IL-1β,
and MDA in patients with UA and between TIMI scores and IL-1β in patients with STEMI. Combining
inflammatory biomarkers with the TIMI risk score could provide better insight into the processes
involved in ACS.
Creating Innovation of Public Value Through Management Information Systems
Authors: Rofi Aliyyu , Putra Fadillah , Sentanu I Gede
Published: February 2022

Abstract: The use of information technology cannot be escaped from everyday life in society. In the context of improving the public sector, the government is required to improve performance, responsibility, and public trust and focus more on providing better services by revitalizing public administration by increasing transparency and prioritizing service quality. The Bureau of Personnel uses the “SIMPEG” application in the form of digitizing the public sector which is considered an extraordinary opportunity to create public value. This research is focused on the approach of the SIMPEG pre and post-mobile SSO. The method adopted by this study was mixed methods. The implementation of SIMPEG mobile SSO at the Ministry of Home Affairs has fulfilled the three aspects of the public values ​​stated by Moore, namely legitimacy and support, operational capabilities, and public value. However, based on the findings within the field, some things are still not appropriate. For example, there is still the use of paper-based administration, so that the mobile SSO service has not been optimized. Based on the dimensions of system quality, information quality, and service quality, SIMPEG based on web-based are categorized as quite sustainable, whereas after using SIMPEG mobile SSO application was classified as very sustainable. When viewed from the results of stress and RSQ values, it can be said that the results of the MDS in this study describe a good model and can represent the problems being discussed and conclude that only SIMPEG mobile SSO application is recommended for sustainability.
A LINGUAGEM DO MATERIAL DIDÁTICO IMPRESSO DE CURSOS A DISTÂNCIA
Authors: Horn Vera
Published: February 2022

Este artigo tem como objetivo demonstrar a relevância da linguagem na concepção de materiais didáticos impressos e seu papel mediador em cursos a distância. Descreve a necessidade, já apontada pelos Referenciais de Qualidade para a Educação Superior a Distância (BRASIL, 2007), de conceber um material didático impresso que detenha características próprias e não seja um apêndice dos cursos presenciais. Para isso, ele deverá ser dinâmico e apresentar-se como um diálogo com o aluno, de modo a promover a autonomia do educando e a responsabilização deste pelo processo de aprendizagem, fundamental em cursos desenvolvidos na modalidade a distância. Para refletir sobre a relevância da linguagem na concepção e elaboração de materiais didáticos impressos, usamos os conceitos bakhtinianos de dialogismo, interação verbal e gêneros do discurso a partir das obras Marxismo e filosofia da linguagem(BAKHTIN, 2006) e Estética da criação verbal(BAKHTIN, 1997). Através do desenvolvimento do presente estudo, foi possível observar que é preciso atentar para a importância da aproximação do discurso científico escrito às condições do discurso narrativo (oral), para a adoção de uma concepção de linguagem que conduza o educando à construção do conhecimento e para a utilização de recursos linguísticos que de fato favoreçam a interação.
Developing Reporting Guidelines for Social Media Research (RESOME) by Using a Modified Delphi Method: Protocol for Guideline Development
Authors: Kaushal Aradhna , Bravo Caroline , Duffy Stephen , Lewins Douglas , Möhler Ralph , Raine Rosalind , Vlaev Ivo , Waller Jo , von Wagner Christian
Published: February 2022

Background

Social media platforms, such as Facebook, Twitter, and Instagram, are being increasingly used to deliver public health interventions. Despite the high level of research interest, there is no consensus or guidance on how to report on social media interventions. Reporting guidelines that incorporate elements from behavior change theories and social media engagement frameworks could foster more robust evaluations that capture outcomes that have an impact on behavior change and engagement.

Objective

The aim of this project is to develop, publish, and promote a list of items for our Reporting Guidelines for Social Media Research (RESOME) checklist.

Methods

RESOME will be developed by using a modified Delphi approach wherein 2 rounds of questionnaires will be sent to experts and stakeholders. The questionnaires will ask them to rate their agreement with a series of statements until a level of consensus is reached. This will be followed by a web-based consensus meeting to finalize the reporting guidelines. After the consensus meeting, the reporting guidelines will be published in the form of a paper outlining the need for the new guidelines and how the guidelines were developed, along with the finalized checklist for reporting. Prior to publication, the guidelines will be piloted to check for understanding and simplify the language used, if necessary.

Results

The first draft of RESOME has been developed. Round 1 of the Delphi survey took place between July and December 2021. Round 2 is due to take place in February 2022, and the web-based consensus meeting will be scheduled for the spring of 2022.

Conclusions

Developing RESOME has the potential to contribute to improved reporting, and such guidelines will make it easier to assess the effectiveness of social media interventions. Future work will be needed to evaluate our guidelines’ usefulness and practicality.

International Registered Report Identifier (IRRID)

PRR1-10.2196/31739
Patient- and Provider-Reported Experiences of a Mobile Novel Digital Therapeutic in People With Opioid Use Disorder (reSET-O): Feasibility and Acceptability Study
Authors: Kawasaki Sarah , Mills-Huffnagle Sara , Aydinoglo Nicole , Maxin Halley , Nunes Edward
Published: February 2022

Background

Medications for the treatment of opioid use disorder, such as buprenorphine, are effective and essential for addressing the opioid epidemic. However, high dropout rates from medication remain a challenge. Behavioral treatment with contingency management and cognitive behavioral counseling has shown promise for improving the outcomes of buprenorphine treatment but is complicated to deliver. The delivery of behavioral treatment through technology-based platforms has the potential to make it more feasible for widespread dissemination.

Objective

reSET-O is a prescription digital therapeutic and a commercial adaptation of the Therapeutic Education System, an internet-based program with a Community Reinforcement Approach to cognitive behavioral therapy. It delivers cognitive behavioral therapy modules and contingency management rewards upon completion of modules and negative urine drug screens. This pilot study aims to assess the feasibility and acceptability of reSET-O in a community-based opioid treatment program with a Hub and Spoke model of care as part of a larger strategy to maintain individuals in treatment. Objective and qualitative results, as well as acceptability and likeability of reSET-O, were obtained from 15 individuals.

Methods

English-speaking individuals aged ≥18 years with a diagnosis of current opioid use disorder were recruited after being on buprenorphine for at least 1 week of treatment. Two 12-week prescriptions for reSET-O were written for the 24-week study. Patient reports of drug use and likeability scales of reSET-O were conducted at weeks 4, 8, 12, and 24 of the study. Qualitative interviews were also conducted. A total of 4 providers were recruited and provided feedback on the acceptability and feasibility of reSET-O.

Results

Of the 15 participants who participated in this pilot study, 7 (47%) completed 24 weeks, and 8 (53%) were unable to complete because of dropout after enrollment, attrition in treatment, or incarceration. An average of US $96 in contingency management rewards were earned by participants for the completion of modules for the duration of the pilot study. Participants’ subjective feedback revealed that reSET-O was easy to use, enjoyable, and helped provide a safe space to admit recurring substance use.

Conclusions

reSET-O was well accepted based on patient and provider feedback in this pilot study; however, adherence and retention in treatment remain areas for improvement. Randomized control trials are needed to assess whether retention of community-based buprenorphine treatment is enhanced through the use of technology-based behavioral interventions such as reSET-O.
Attentional Harms and Digital Inequalities (Preprint)
Authors: Hartford Anna , Stein Dan J
Published: February 2022

UNSTRUCTURED

Recent years have seen growing public concern about the effects of persuasive digital technologies on public mental health and well-being. As the draws on our attention reach such staggering scales and as our ability to focus our attention on our own considered ends erodes ever further, the need to understand and articulate what is at stake has become pressing. In this ethical viewpoint, we explore the concept of attentional harms and emphasize their potential seriousness. We further argue that the acknowledgment of these harms has relevance for evolving debates on digital inequalities. An underdiscussed aspect of web-based inequality concerns the persuasions, and even the manipulations, that help to generate sustained attentional loss. These inequalities are poised to grow, and as they do, so will concerns about justice with regard to the psychological and self-regulatory burdens of web-based participation for different internet users. In line with calls for multidimensional approaches to digital inequalities, it is important to recognize these potential harms as well as to empower internet users against them even while expanding high-quality access.
Dengue Fever Outbreak in Al-Garrahi District, Al-Hudaydah Governorate, Yemen, 2019 (Preprint)
Authors: Al-Jamrah Khaled Mohammed , Nassar Abdulkareem , Mohathab Ibrahim , Al Amad Mohammed
Published: February 2022

BACKGROUND

Dengue fever (DF) has re-emerged in Yemen with a higher frequency during the last years. On November 6, 2019, an increased number of suspected DF cases in Al-Garrahi district was reported. On November 7, 2019, a team was sent to investigate.

OBJECTIVE

This study aims to confirm the existence of an outbreak, describe the outbreak characteristics, and recommend suitable intervention for control.

METHODS

A descriptive study was conducted. The World Health Organization case definition was used to identify patients. An active search from house to house, along with entomological investigation and health education, was conducted. A line list was used to collect data. Blood specimens were collected and tested by enzyme-linked immunosorbent assay for dengue IgM. Frequency, percentage, and rates were calculated, and the population from the central statistical organization was used.

RESULTS

A total of 2067 cases met the case definition. Of them, 51% were males and 32% were aged <10 years. All patients complained of fever, headache, and arthralgia (100%), followed by myalgia and retro-orbital pain (67% and 39%, respectively). The first case patient was in week 41, and the peak was reached with 1058 patients in week 46. The overall attack rate was 16 of 1000, significantly higher among patients aged 10 years to <50 years and ≥50 years compared with patients aged <10 years (17 and 19/1000 vs 14/1000; P<.001). Of 20 tested blood samples, 12 (60%) were IgM positive. The house index was 70%, the container index was 50%, and the Breteau index was 140. Vector control measures with community participation were intensified in week 46, and patient cases decreased to 140 in week 48.

CONCLUSIONS

A dengue outbreak was confirmed in Al-Garrahi district. The spread of infection was facilitated by storing water and the presence of indoor larvae. The findings emphasize the importance of health awareness and community participation for containing DF outbreaks.
Molecular interactions of Andrographis paniculata Burm. f. Active Compound with Nuclear Receptor (CAR and PXR): An In Silico Assessment Approach
Authors: Sundhani Elza , Nugroho Agung Endro , Nurrochmad Arief , Lukitaningsih Endang
Published: February 2022

The study aims to analyze the potential Herb-Drug Interactions (HDIs) of the chemical compound in Andrographis paniculate Burm. f. against Constitutive Androstane Receptor (CAR) and Pregnane X Receptor (PXR). The 1XVP and 1SKX obtained from the Protein Data Bank (PDB) were used as the targeted protein. The molecular docking analysis was done using the Molecular Operating Environment (MOE) and molecular dynamics simulation using Gromacs. The results of the docking analysis showed that 14-Deoxy-11,12-didehydroandrographolide had the strongest binding energy (1XVP-21.0998 Å) with the Arene-H binding type on Tyr326 and Andrographidine A had the strongest binding energy (1SKX-24.7363 Å) with the Arene-H binding type on Trp299. While Andrographolide is the major component, it also has a high affinity for the two PDB IDs (1XVP-17.4044 Å and 1SKX-21.8881 Å). Based on the RMSD value, the radius of gyration (Rg), and MM/PBSA on molecular dynamic simulations, it shows that the ligand and protein complex as a whole can bind strongly to amino acid residues at the active site. The complex also has sufficient stability and good affinity. Therefore, this study can predict the mechanism in HDIs, especially in CYP 450 expression through the activation pathways of CAR and PXR receptors.
Comparison of the Adsorption Ability of MgAl-HC, CaAl-HC, and ZaAl-HC Composite Materials Based on Duku Peel Hydrochar in Adsorption of Direct Green Anionic Dyes
Authors: Juleanti Novie , Normah Normah , Siregar Patimah Mega Syah Bahar Nur , Wijaya Alfan , Palapa Neza Rahayu , Taher Tamizi , Hidayati Nurlisa , Mohadi Risfidian , Lesbani Aldes
Published: February 2022

Preparation of composite material from layered double hydroxide (LDH) with hydrochar (HC) from duku peel produces CaAl-HC, MgAl-HC, and ZnAl-HC have shown the success of the preparation process as evidenced by characterizations such as XRD and FT-IR. The XRD characterization data evidenced the typical diffraction of the hydrochar around 2θ = 20° in the composite material. FTIR analysis is a characterization that supports the success of composite materials, which showed the presence of typical vibrations of HC at 3245, 2931, and 1635 cm–1 contained in the composite spectrum. The application of MgAl-HC, CaAl-HC, and ZnAl-HC composites as adsorbents showed Qmax (adsorption ability) values of 94.340 mg/g, 128.205 mg/g, and 89.286 mg/g. Overall the adsorption process is endothermic with a positive enthalpy value, and a negative Gibbs free energy value indicates a spontaneous adsorption process. The isotherm model of MgAl-HC, CaAl-HC, and ZnAl-HC show that the Langmuir isotherm model is more dominant, as indicated by the R2 value closer to 1 which indicates that the adsorption process takes place in a monolayer.
¿Populismo o lealtad racional hacia el presidente Andrés Manuel López Obrador (AMLO)? (El perfil del partidario de la 4T y las elecciones intermedias 2021)
Authors: Gómez Vilchis Ricardo Román
Published: February 2022

¿Cuál es el perfil de los partidarios de los gobiernos catalogados como populistas? En específico como estudio de caso: ¿quiénes apoyan a la 4T (Cuarta Transformación)? A partir de un análisis econométrico, modelos ordered probit, este trabajo es uno de los primeros que —con datos duros y actuales— argumenta, ofreciendo evidencia empírica sólida, que el perfil del partidario de la 4T obedece a una mezcla de un cierto populismo y una lealtad racional del votante. Si bien es cierto, los menos ilustrados y de escasos recursos económicos son quienes más apoyan una concentración del poder de líder carismático, posturas y políticas con rasgos clientelares (características del populismo) al mismo tiempo existen variables, consideradas tradicionalmente propias de un perfil racional del votante (evaluación de la economía del país y del bolsillo del ciudadano), que poseen un fuerte impacto en el apoyo hacia la 4T. Esto se verifica con una encuesta realizada en 2019, enfocada en el perfil del partidario de la 4T y con los resultados de una encuesta nacional de salida, exit polls, de 2021, concentrada en el perfil del votante que apoyó a morena (Movimiento de Regeneración Nacional) en las elecciones intermedias de 2021.
La ideología de los independientes y su decisión de voto en la elección de diputados federales de 2021
Authors: Cisneros Yescas Gerardo Isaac
Published: February 2022

Se analiza el papel de los electores sin identidad partidaria en la elección de Diputados Federales de 2021, acentuando de manera novedosa que las características ideológicas de los independientes repercutieron en el apoyo y rechazo a cada una de las principales opciones. Los resultados muestran que los independientes sin ubicación ideológica y los independientes de izquierda apoyaron a la coalición Juntos Hacemos Historia, mientras que los independientes de derecha a la coalición Va por México. Los independientes de centro dividieron su apoyo entre ambas coaliciones. En la decisión de voto, los independientes de derecha y de centro dieron mayor importancia a la evaluación de la economía y de la seguridad, mientras que, los independientes de izquierda y sin ubicación ideológica a la evaluación sobre la vacunación contra Covid-19. Esto representa una contribución teórica y empírica al estudio de la independencia partidista en México.
Calidad de vida relacionada con la salud en adultos con normopeso, sobrepeso y obesidad
Authors: Arzate Hernández Giovanny
Published: February 2022

El sobrepeso y la obesidad actualmente presentan una alta prevalencia a nivel mundial, se encuentran relacionadas con enfermedades de tipo crónico degenerativas, mortalidad prematura y con la disminución de la calidad de vida. El propósito de la presente investigación fue comparar la calidad de vida relacionada con la salud (CVRS) entre grupos por su estado de nutrición y por sexo. Se contó con una muestra de 202 participantes (84 hombres y 118 mujeres) distribuidos por su estado de nutrición en: normopeso, sobrepeso y obesidad, a los cuales se les administró el cuestionario SF-36. En la muestra general predomino la dimensión de Función Física (FF) siendo considerada como muy buena, las puntuaciones obtenidas en las dimensiones de Rol Emocional (RE), Rol Físico (RF), Vitalidad (VT) y Salud Mental (SM) se ubicaron en un rango estimado como bueno y solamente la dimensión de Salud General (SG) se consideró regular. En el caso de la comparación realizada entre los grupos por estado de nutrición no se encontró diferencias estadísticamente significativas entre estos, sin embargo, en la comparación realizada por sexo se encontraron diferencias estadísticamente significativas en los factores de FF, SM, VT y RE a favor del grupo de los hombres.
Niveles de consanguinidad y sus efectos sobre la expresión fenotípica en ganado Holstein
Authors: García-Ruiz Adriana , Martínez-Marín Gustavo Javier , Cortes-Hernández José , Ruiz-López Felipe De Jesús
Published: February 2022

El objetivo del presente estudio fue calcular los niveles de consanguinidad en la población Holstein de México y evaluar su efecto sobre la producción de leche, grasa, proteína y puntos finales de conformación. La información de pedigrí constó de 326,238 animales, a los cuales se les calculó la consanguinidad a través del algoritmo recursivo modificado (INBUPGF90). Se obtuvieron tendencias de consanguinidad de animales nacidos de 1990 a 2018 a través de un análisis de regresión, y se evaluó el efecto de la consanguinidad sobre caracteres productivos con un análisis de varianzas, para lo cual se incluyó información fenotípica de 68,779 animales. Se formaron seis grupos de acuerdo al nivel de consanguinidad (1= <1%, 2= ≥1 y <2%, 3= ≥2 y <3%, 4= ≥3 y <4%, 5= ≥4 y <5%, y 6= ≥5%). Los resultados mostraron que, por cada punto porcentual de aumento en la consanguinidad, se disminuye la producción de leche, grasa y proteína en 88, 3.16 y 2.57 kg (P<0.0001). A niveles bajos de consanguinidad (<5%), no se detectó ningún efecto sobre la producción de grasa y proteína. Sin embargo, cuando la consanguinidad aumentó a más de 5%, la pérdida en producción fue de 12 kg de grasa y de 9 kg en proteína. También se observó que los animales con menor promedio de conformación, presentan bajos niveles de consanguinidad (<1%) y los niveles más elevados, no mostraron diferencias significativas entre ellos; lo que ratifica que la conformación funcional es menos sensible a los efectos de la consanguinidad que otras características de interés económico. Se recomienda promover programas de selección basados en contribuciones óptimas para maximizar las ganancias genéticas y controlar los niveles de consanguinidad.
Detección del virus del síndrome reproductivo y respiratorio en piaras porcinas de Baja California, México
Authors: Gómez-Gómez Sergio Daniel , López-Valencia Gilberto , Herrera-Ramírez José Carlomán , Trasviña-Muñoz Enrique , Monge-Navarro Francisco Javier , Moreno-Torres Kattya , García-Reynoso Issa Carolina , Medina-Basulto Gerardo Enrique , Cabanillas-Gámez Miguel Arturo
Published: February 2022

The objective of this study was to assess the presence of genotype 2 porcine reproductive and respiratory syndrome virus (PRRSV-2) in Baja California (Baja), as well as the standardization of the qRT-PCR technique. A cross-sectional study was conducted from 2016 to 2017 in farms from Baja. It was obtained 97 blood samples from clinically healthy, not-vaccinated boars and sows. Primers were designed and standardize, in order to perform qRT-PCR tests from the buffy coat. Every positive results were confirmed by sequence studies. It was found that 9.3 % of the samples were positive. The positive samples came from 66.6 % of the sampled regions. This study demonstrates the presence of PRRSV-2 in Baja, therefore, it is necessary to conduct epidemiological studies in order to identify the magnitude of the problem and to establish preventive and control measures.
Relaciones entre estacionalidad, características corporales y leptina en el inicio de la pubertad en vaquillas Bos taurus taurus y Bos taurus indicus en el trópico mexicano
Authors: Hernández-López Carlos , Calderón-Robles René Carlos , Villa-Godoy Alejandro , Ríos-Utrera Ángel , Román-Ponce Sergio Iván , González-Padilla Everardo
Published: February 2022

El estudio analizó, en dos años, los efectos de raza [Brahman (BHM; n= 65); Suizo Europeo (SE; n= 56)], suplementación con Zilpaterol® (ZIL; tratadas o testigo), estación de nacimiento (primavera u otoño) y sus interacciones, sobre superficie corporal (SC), edad (EPB), peso corporal (PPB), condición corporal (CC), profundidad del músculo largo dorsal (MD), grosor de grasa dorsal (GD) y concentración sérica de leptina (LEP) a la pubertad (PB) de 121 vaquillas. A la PB, las BHM fueron más pesadas y tuvieron más edad que las SE (376.8 ± 7.4 vs 302.0 ± 6.6 kg; 588.1 ± 14.7 vs 445.5 ± 12.5 días). ZIL aumentó EPB, PPB, CC y MD, pero no afectó GD y LEP. Las BHM tuvieron 18 % más SC que las SE. Sin embargo, la diferencia en PPB/SC fue sólo de 6.4 %. Cuando se usó peso metabólico (PM) como proporción de la SC (PM/SC) en lugar de PPB, la diferencia entre BHM y SE desapareció (P>0.05). El GD fue 63.7 % mayor en BHM que en SE. Las nacidas en primavera iniciaron la PB con 24.4 % menos GD que las nacidas en otoño. La mayoría de las vaquillas BHM (73.8 %) inició la PB en los meses en que las horas luz iban en aumento (P<0.05), mientras que en las SE el inicio de la PB estuvo uniformemente distribuido a través del año, independientemente de la duración de las horas luz; este efecto se mostró en los dos años de estudio. Se concluye que el establecimiento de la pubertad es un fenómeno multifactorial; la estacionalidad afecta a BHM y SE de manera diferenciada y, aparentemente, la SC es un factor importante, probablemente asociado con la eficiencia en la utilización de energía. Este trabajo reitera la importancia de la grasa dorsal y documenta, por primera vez PM/SC y su asociación con el establecimiento de la pubertad.
Analisis Kejenuhan dan Minat Belajar Siswa dalam Pembelajaran Daring pada Pelajaran Biologi di SMAN 1 Unggulan Muara Enim
Authors: Rulita Meta , Wardhani Sri , W.S. Sumah Astrid
Published: February 2022

This research was motivated by several statements by students who felt boredom in learning and reduced interest in learning in online learning. The purpose of this study was to analyze and determine the factors that cause student boredom and interest in online learning in biology lessons at SMAN 1 Unggulan Muara Enim. The research method used is descriptive qualitative. The subjects of this study were students of class XI MIPA and biology teachers. Data were collected by direct observation, open questionnaires to students via google form, direct biology teacher interviews and student interviews via google form. Data analysis was carried out using the Miles & Huberman interactive analysis technique. The results showed that the learning saturation factor showed thad students experienced boredom in the learning process because the learning method provided by the teacher was not interesting. Meanwhile, the results of the study showed that students' interest in learning factors showed that all students did the assignments given by the teacher. This shows that the condition of learning boredom felt by students does not reduce students' interest in learning in participating in online learning at SMAN 1 Unggulan Muara Enim.
Abstrak. Penelitian ini dilatar belakangi oleh beberapa pernyataan siswa yang merasakan kejenuhan belajar dan minat belajar berkurang dalam pembelajaran daring. Tujuan dari penelitian ini adalah untuk menganalisis dan mengetahui faktor yang menyebabkan kejenuhan dan minat belajar siswa dalam pembelajaran daring pada pelajaran biologi di SMAN 1 Unggulan Muara Enim. Metode penelitian yang digunakan adalah deskriptif kualitatif. Subjek penelitian ini adalah siswa kelas XI MIPA dan guru biologi. Data dikumpulkan dengan observasi melalui secara langsung, kuesioner terbuka kepada siswa melalui google form, wawancara guru biologi secara langsung dan wawancara siswa melalui google form. Analisis data dilakukan menggunakan teknik analisis interaktif Miles & Huberman. Hasil penelitian menunjukkan bahwa faktor kejenuhan belajar siswa menunjukkan jika siswa mengalami kejenuhan dalam proses pembelajaran dikarenakan metode pembelajaran yang diberikan oleh guru tidak menarik. Sedangkan pada hasil penelitian faktor minat belajar siswa menunjukkan jika seluruh siswa mengerjakan tugas yang diberikan oleh guru. Hal ini menunjukkan jika kondisi kejenuhan belajar yang dirasakan oleh siswa tidak menurunkan minat belajar siswa dalam mengikuti pembelajaran daring di SMAN 1 Unggulan Muara Enim.
The association of chiral characteristic with drug withdrawal due to safety: a comparative analysis
Authors: Bahar Ayfer , Aydin Volkan , Vizdiklar Caner , Akici Ahmet
Published: February 2022

Aim: Chirality of drugs might be associated with safety issues through
pharmacokinetic or pharmacodynamic variations, interactions, or direct
toxicological responses. This study aimed to examine chiral status of
the drugs withdrawn from the market. Methods: We searched the literature
regarding withdrawn drugs between 1950-2020 due to safety-related issues
and identified 395 drugs. We examined their chirality and assigned into
one of three categories: achiral compound, chiral mixture, and pure
enantiomer. We compared their distribution at ATC-1 level, duration on
the market, and adverse drug reactions leading to their withdrawal.
Results: We identified that 52.4% (n=207) of withdrawn drugs were
achiral, whereas 27.6% (n=109) were chiral mixtures and 20.0% (n=79)
were pure enantiomers. The mean duration on the market was 24.6±27.5
years. The groups did not differ in terms of mean duration on the
market. Chiral mixtures were significantly more withdrawn than were
achirals in cardiovascular system drugs (17.4% vs. 7.7%, p=0.01). In
musculoskeletal system drugs, pure enantiomers were significantly less
withdrawn (2.5%) compared to achirals (12.6%, p=0.01) and chiral
mixtures (11.9%, p=0.03). Hepatotoxicity was significantly less common
in pure enantiomers (5.4%) compared to chiral mixtures (12.7%, p=0.04)
and achirals (17.0%, p<0.01). Cardiovascular toxicity was
significantly more common in chiral mixtures (14.5%) compared to that
in achiral drugs (7.5%, p=0.02). Conclusion: Our study showed slightly
higher representation of chiral mixtures among withdrawn drugs over pure
enantiomers. The assessment of withdrawal reasons further indicates
higher tendency of chiral mixtures towards hepatotoxicity and
cardiovascular toxicity.
Motor learning and working memory in children: The role of cognitive-motor and motor-motor dual-task training
Authors: Hoshyari Masoumeh , Saemi Esmaeel , Doustan Mohammadreza
Published: February 2022

The present study aims to examine the effects of two dual-task training methods (motor-motor and cognitive-motor) as well as a single task method on static and dynamic balance and also on the working memory in children. Forty-five children (all male; mean age 8.82 ? 0.83 years) were selected and randomly assigned into three experimental groups. In the pretest, posttest, and retention stages, the participants took static, and dynamic balance tests, as well as an n-back task. In the training stage, the participants practiced selected balance training tasks under dual-task motor-motor and motor-cognitive conditions as well as a single task over a period of four weeks at two sessions per week. The results of the paired samples t-test indicated that children in all groups improved their balance performance and working memory (p ? .05). The results of ANCOVA showed that the balance training group under motor-motor dual-task conditions outperformed the other two groups in terms of the dynamic balance scores (p ? .05). An improved performance was also observed for the cognitive-motor dual-task conditions compared to the single-task group (p ? .01). In terms of static balance and working memory, both dual-task groups, regardless of the types of their tasks, outperformed the single task group (p ? .05).
Basal Cell Carcinoma Arising within a Bacillus Calmette-Guerin Scar: Case Report and Literature Review
Authors: Tyczyńska Kinga , Szepietowska Marta , Krajewski Piotr K. , Szepietowski Jacek C.
Published: February 2022

Abstract is missing (Short communication)
Validación del diseño de un ambiente virtual de aprendizaje ava para el curso de ética y filosofía política del programa de ciencias políticas bajo las características del aprendizaje significativo de la Universidad del Tolima.
Authors: Montes Mora John Fredy , Nañez Rodr´íguez José Julián
Published: February 2022

El presente artículo de investigación muestra avances significativos del trabajo de grado para optar el título de Magister en E-learning por la Universidad Autónoma de Bucaramanga - UNAB.  El proyecto dispone de un Ambiente Virtual de Aprendizaje – AVA, que dio respuesta a las necesidades pedagógicas de los estudiantes del curso de Ética y Filosofía Política del programa de Ciencias Políticas de la Universidad del Tolima; brindando herramientas tecnológicas y comunicativas que permitieron la discusión y reflexión en torno a la incorporación de las TIC como ejes fundamentales en la educación superior, lo anterior amplió la visión de estar a la vanguardia en cuanto a las estrategias pedagógicas implementadas para la formación de los futuros profesionales del programa.  El enfoque de investigación utilizada fue la Investigación Acción, que se ajustó a las necesidades del proyecto, posibilitó el abordaje de forma simultánea de procesos de orden práctico y teórico, a la vez implementó la observación, planificación y reflexión.
Efektivitas Metode Latihan Aerobik dan Anaerobik untuk Menurunkan Tingkat Overweight dan Obesitas
Authors: Hita I Putu Agus Dharma
Published: February 2022

Overweight dan obesitas merupakan salah satu faktor resiko dari penyakit tidak menular yang bersifat kronis. Penyebab mendasar dari terjadinya overweight dan obesitas pada umumnya adalah ketidakseimbangan antara kalori yang dikonsumsi dan kalori yang dikeluarkan. Tujuan dari penelitian ini adalah untuk mengetahui perbedaan efektivitas antara metode latihan aerob dan metode latihan anaerob untuk menurunkan tingkat overweight dan obesitas. Metode yang digunakan dalam penelitian ini menggunakan metode studi literatur. Data dikumpulkan dengan metode studi pustaka, kemudian data yang diperoleh akan dikompulasi, dianalisis, dan disimpulkan sehingga mendapatkan sebuah kesimpulan. Setiap metode latihan yang akan diberikan kepada individu sebaiknya harus mempertimbangkan beberapa faktor, seperti kondisi individu itu sendiri dan tujuan dari metode latihan tersebut. Dalam suatu proses latihan harus mempertimbangkan kriteria FITT (frequency, intensity, time, type). Sumber energi utama yang digunakan oleh tubuh dalam melaksanakan aktivitas sangat tergantung dari intensitas dan durasi latihan yang dilakukan. Pada umumnya energi yang digunakan dalam latihan terdiri dari karbohidrat, lemak, dan phosphocreatine (PCr). PCr digunakan oleh tubuh saat melakukan durasi latihan yang relatif singkat, yaitu sekitar 1-10 detik. Sedangkan jika terjadi peningkatan pada durasi latihan, maka lemak didalam tubuh akan dijadikan sebagai sumber energi utama. Hal ini dapat terjadi dikarenakan adanya perubahan hormonal yang mengakibatkan perubahan penggunaan karbohidrat menjadi lemak yang digunakan sebagai sumber energi oleh tubuh selama proses latihan tersebut. Perubahan ini akan terjadi jika durasi latihan yang dilakukan berlangsung lebih dari 20 menit. Jadi, metode latihan aerobik lebih cocok diterapkan untuk individu yang ingin menurunkan berat badan, dikarenakan pelaksanaan dari metode latihan ini dilaksanakan dengan intensitas rendah namun durasi yang relatif lama. Sedangkan metode latihan anaerob lebih cocok diterapkan pada atlet atau individu yang ingin meningkatkan VO2max dikarenakan metode latihan ini dilaksanakan dengan intensitas tinggi namun durasi yang relatif lebih pendek.
3D-Position Determination using GNSS Techniques – A Comparative Analysis
Authors: Adeseye Temitayo A. , Suara Gafar
Published: February 2022

This study was carried out to determine 3D-position of selected points within Obafemi Awolowo University. The points were located at Africa Regional Institute for Geospatial Information Science and Technology (AFRIGST), Central Technological and Laboratory Workshops (CTLW), main Bus Stop, Religion ground, New Environmental Design and Management (New EDM), and Spider building. China HuaCe Corporation (CHC) GPS and Promark 3 GPS were used to carry out observation on the selected points. The data gotten were post processed using GNSS solution software for Promark3, Compass software for CHC GPS and the result gotten were compared with the known coordinates of those points. The data was analyzed using Statistical Package for Social Sciences (SPSS) to determine the most accurate instrument between the two. The occupation time for the two instruments on each station was 45 minutes. Analysis of Variance (ANOVA) and Chi square Variance analysis were conducted, the result showed that there is no significant difference between the observations of the two instruments in comparison with the adjusted coordinate. It can be concluded that any of the two instruments can be used for 3D point positioning to obtain accurate result.
Investigations of Decoupled Trigonometric Saturated and Fuzzy Logic Techniques for the Automatic Frequency Control of Islanded Microgrid
Authors: Alshehri Mohammed Ali , Kumar R. Sreerama
Published: February 2022

This paper involves the investigation of new techniques for the automatic load frequency control of islanded Microgrids. Microgrids are being established as a part of smart grid environment. In modern power systems, smart grid represents the solution for many of traditional power system problems such as frequency fluctuations. Frequency fluctuations have negative consequences in terms of electrical equipment life, production cost and production losses relative to costumers and electricity producers. So, the frequency of power system must be kept in acceptable range. In order to operate a power system with fixed frequency, it is necessary to always maintain a balance between the generation and the consumption of active power. The frequency droop control methods are widely used to control active power and frequency of the parallel synchronous generators in the traditional power grid. At present, this method has also been applied to the control of parallel inverters to share the load demand in proportion to their ratings. In order to improve the frequency control of traditional droop control technique applied in islanded microgrid, It is proposed to investigate the Decoupled Trigonometric Saturated (DTS) and fuzzy droop control techniques on islanded microgrids which uses meshed parallel inverter systems. To verify the performance of the proposed ALFC based on Decupled trigonometric saturated controller, fuzzy PI controller the MATLAB/SIMULINK environment is used.