bluuebunny/crossref_metadata_2025 huggingface dataset:
Do we need delocalised wavefunctions for the excited state dynamics of 1,1-difluoroethylene?
Authors: Gómez Sandra , Singer Nadja K. , González Leticia , Worth Graham A.
Published: April 2023

In this work, we set up a model Hamiltonian to study the excited state quantum dynamics of 1,1-difluoroethylene, a molecule that has equivalent atoms exchanged by a torsional symmetry operation leading to equivalent minima on the potential energy surface. In systems with many degrees of freedom where the minimum energy geometry is not unique, the ground state wavefunction will be delocalised among multiple minima. In this small test system, we probe the excited state dynamics considering localised (in a single minimum) and delocalised (spread over among multiple minima) wavefunctions and check whether this choice would influence the final outcome of the quantum dynamics calculations. Our molecular Hamiltonian comprises seven electronic states, including valence and Rydberg states, computed with the MS-CASPT2 method and projected onto the vibrational coordinates of the twelve normal modes of 1,1-difluoroethylene in its vibrational ground state. This Hamiltonian has been symmetrised along the torsional degree of freedom to make both minima completely equivalent and the model is supported by the excellent agreement with the experimental absorption spectrum. Quantum dynamics results show that the different initial conditions studied do not appreciably affect the excited state populations or the absorption spectrum when the dynamics is simulated assuming a delta pulse excitation.
A reassessment of the Erie Interstade from field work in the Cayuga basin, central New York
Authors: Karig Daniel E.
Published: April 2023

The Erie Interstade is generally accepted to have been a relatively warm period associated with retreat of the Laurentian ice sheet into the Lake Ontario basin, followed by a readvance to the Valley Heads (Port Bruce Stade) ice front in central New York. Recent investigations in the Cayuga basin indicate that this ice front retreated only to the Ithaca area during the Erie Interstade. In the Cayuga trough, Erie glaciolacustrine strata underlie Valley Heads deposits. Plant assemblages in these strata indicate a sub-Arctic environment. Erie deposits also occur in the Fall Creek Valley, where a varved sequence below Valley Heads till and above Nissouri till indicate deposition close to a retreating ice front. Remanent magnetic declination in the varves is 357°, best correlated with lower Newport beds of the Middleville fm in the Mohawk Valley and suggests an age of 17.7 ± 0.1 ka cal for the peak of the Erie retreat. Retreat only to the Ithaca area is based on the lack of Erie deposits north of Ithaca, an oscillation of the ice front around the south end of Cayuga Lake, and the lack of a fluvial interval in the Cayuga trough that would have marked retreat into the Ontario basin. Ice core data from Greenland and sea level studies demonstrate that the Erie Interstade was neither a warm period nor a time of significant sea level rise. The Erie Interstade retreat/Valley Heads readvance appears instead to represent a minor reversal in the general, slow ice front retreat from the Last Glacial Maximum to the warm up at Melt Water Pulse 1.
Semiampleness for generalized pairs
Authors: Chaudhuri Priyankur
Published: April 2023

We prove that if [Formula: see text] is a generalized klt pair with [Formula: see text] nef and abundant, then [Formula: see text] is semiample.
Low-lying bound and resonance states in Λ61Ca and ΛΛ62Ca
Authors: Alam M. , Hasan M. , Mondal S. H. , Khan Md. A.
Published: April 2023

In this paper, the energy, and wavefunctions of the low-lying bound and resonance states of [Formula: see text]Ca and [Formula: see text]Ca are studied. For [Formula: see text]Ca we adopted [Formula: see text]Ca two-body cluster model while for [Formula: see text]Ca we adopted [Formula: see text]Ca three-body cluster model. Two models of potentials, namely SH: Hulthén type and WS: Woods–Saxon type potentials, each having a spin-orbit coupling term is chosen for the [Formula: see text]-nucleus pair while three-range Gaussian (TRG) Nijmegen hardcore and softcore potential models are chosen for [Formula: see text] pair. The resulting few-body (two- and three-body) Schrödinger equations are solved numerically to get the bound state energies and wavefunctions. For the three-body calculation, we used hyperspherical coordinates. The formalism of supersymmetric quantum mechanics is applied to construct a one-parameter family of isospectral potential to investigate the resonance states of the [Formula: see text]Ca ([Formula: see text]Ca) core-[Formula: see text] two-body system. To study the effect of replacement of the outer core valence nucleon(s) of [Formula: see text]Ca by [Formula: see text] hyperon(s), two- and three-body cluster model calculations for the bound states of [Formula: see text]Ca and [Formula: see text]Ca are also carried out using the same set of two-body potentials, as used for [Formula: see text]Ca and [Formula: see text]Ca respectively. And a clear enhancement in the one- and two-[Formula: see text] separation energies and a shrinking of the overall size of the nucleus is indicated. The computed results are compared with some of those found in the literature.
The Gálvez-Carrillo–Kock–Tonks conjecture for locally discrete decomposition spaces
Authors: Forero Wilson
Published: April 2023

Gálvez-Carrillo et al. [Decomposition spaces, incidence algebras and Möbius inversion III: The decomposition space of Möbius intervals, Adv. Math. 334 (2018) 544–584] constructed a decomposition space [Formula: see text] of all Möbius intervals, as a recipient of Lawvere’s interval construction for Möbius categories, and conjectured that [Formula: see text] enjoys a certain universal property: for every Möbius decomposition space [Formula: see text], the space of culf functors from [Formula: see text] to [Formula: see text] is contractible. In this paper, we work at the level of homotopy 1-types to prove the first case of the conjecture, namely for locally discrete decomposition spaces. This provides also the first substantial evidence for the general conjecture. This case is general enough to cover all locally finite posets, Cartier–Foata monoids, Möbius categories and strict (directed) restriction species. The proof is 2-categorical. First, we construct a local strict model of [Formula: see text], which is then used to show by hand that the Lawvere interval construction, considered as a natural transformation, does not admit other self-modifications than the identity.
An Evaluation of Fluorouracil plus Paclitaxel and Oxiliplatin as a First‐Line Treatment for Advanced Gastric Squamous Cell Carcinoma
Authors: Qin Jie , Shi Yingpeng , Zheng Xueli , Lan Ya , Zhang Mingxin , Liu Mi
Published: April 2023

Objective. To investigate the efficacy of fluorouracil (FU) combined with paclitaxel (PTX) and oxaliplatin (OXA) as the first‐line treatment for advanced gastric signet ring cell carcinoma (SRCC) and its influence on human epidermal growth factor receptor 2 (HER‐2) expression. Methods. We collected one hundred and sixty‐eight patients with advanced gastric SRCC, including 87 patients treated with FU combined with PTX and OXA as the study group (SG) and 81 patients treated with FU combined with OXA as the control group (CG). We compared indicators such as efficacy and adverse reactions after treatment between the two groups and also detected serum HER‐2 expression pre‐ and post‐treatment. Results. The incidence of adverse reactions differed insignificantly between SG and CG (P > 0.05). SG presented a notably higher objective response rate (ORR) and disease control rate (DCR) than that of CG (P < 0.05). After treatment, the serum HER‐2 expression level of patients in both groups decreased significantly (P < 0.05), and that in SG was significantly declined compared to CG (P < 0.05). HER‐2 was negatively correlated with the efficacy of both SG and CG. The 1‐year survival rate in SG (29.89%) was significantly higher than that in CG (16.05%) (P < 0.05). The median OS and PFS were higher in DG than that in CG (P < 0.05). Conclusion. FU combined with PTX and OXA can effectively improve the efficacy of first‐line treatment for advanced gastric SRCC while reducing HER‐2 expression, without increasing the adverse reaction rate. This treatment is worthy of clinical promotion.
Investigating the Effect of Curing Activators on the Cure Kinetics of Acrylonitrile–Butadiene Rubber Filled with Graphene Oxide and Reduced Graphene Oxides Nanocomposites
Authors: Mensah Bismark , Onwona-Agyeman Boateng , Efavi Johnson Kwame , Ofor Ralph Abakah , Zigah Mawufemor , Koranteng Joyce , Karikari Maxwell , Nsaful Frank , Addo Daniel Akwei
Published: April 2023

For the first time, acrylonitrile–butadiene rubber (NBR)–graphene oxide (GO) and reduced graphene oxide (rGO) composites were prepared without cure activators: zinc oxide/stearic acid (ZnO/SA) and studied. The vulcanization characteristics of the compounds were systematically studied at 160–190°C, with the aid of rheometer and differential scanning calorimetry (DSC) techniques. NBR revealed rapid curing time (t90) with greater cure rate index compared with NBR–GO/rGO composites for the rheometer measurement. This results were in correspondence with the activation energies Ea (kJ/mol) calculated by Ozawa and Kissinger models of vulcanization kinetics. NBR–rGO obtained reduced t90 and Ea (kJ/mol) than NBR–GO, perhaps due to lower oxygenated groups: epoxide (–C–O–C–), carboxyl (–O–C=O), and hydroxyl (–OH) present. Although, the composites delayed in curing, they significantly recorded high tensile properties with high reinforcing factors than NBR. The order of increasing mechanical properties: NBR < NBR–rGO < NBR–GO followed the same order of increasing crosslinking density. In terms of tensile strength, NBR–GO-1 obtained 62.5% and 18.2% increment than NBR and NBR–rGO-1, respectively. The findings from this study indicate that the absence of ZnO/SA in rubber compounds may slow down curing of rubber–GO/rGO composites and lower networks compared with those containing activators ZnO/SA. However, optimization of ZnO/SA and with desired functional groups on graphene and derivative graphene sheets (GDS) including other proposed factors may enhance the curing speed of rubber–GDS based systems, without compromising their mechanical integrity for advanced applications.
Green’s Functions on Various Time Scales for the Time-Fractional Reaction-Diffusion Equation
Authors: Zhokh Alexey , Strizhak Peter
Published: April 2023

The time-fractional diffusion equation coupled with a first-order irreversible reaction is investigated by employing integral transforms. We derive Green’s functions for short and long times via approximations of the Mittag-Leffler function. The time value for which the crossover between short- and long-time asymptotic holds is presented in explicit form. Based on the developed Green’s functions, the exact analytic asymptotic solutions of the time-fractional reaction-diffusion equation are obtained. The applicability of the obtained solutions is demonstrated via quantification of the reaction-diffusion kinetics during heterogeneous catalytic chitin conversion to chitosan.
Molecular Mechanism of the Therapeutic Effect of Peach Blossom against Constipation: An Exploratory Study Based on Network Pharmacology Analysis and Molecular Docking Verification
Authors: Ma Bo , Ning Jinyu , Wang Fengyun , Zheng Huiling , Han Liang
Published: April 2023

Objective. The aim of the study is to verify the active ingredients of peach blossom and to explore the molecular mechanisms of their therapeutic effects against constipation through network pharmacology and molecular docking analysis. Methods. The potential active ingredients of peach blossom were identified from published literature and the BAT‐TCM database, and their potential targets were predicted using the SwissTargetPrediction and PharmMapper platforms. In addition, targets related to constipation were retrieved using OMIM, DrugBank, GeneCards, TTD, and DisGeNET databases. The intersection of drug targets and disease targets was considered as the potential targets of peach blossom in the treatment of constipation. The STRING platform was used to construct a protein interaction network. Gene ontology (GO) functional analysis and KEGG pathway enrichment analysis were performed on key targets using the DAVID database. Molecular docking verification between the active ingredients of peach blossom and the targets was conducted using AutoDock software. Results. A total of 33 active ingredients of peach blossom and 185 corresponding targets were identified, and 88 intersection targets were obtained after Venny mapping. These 33 active ingredients (including naringenin, aromadendrin, and cordycepin) in peach blossom may play a role in the treatment of constipation by regulating signaling pathways through targets such as EGFR, VEGFA, ESR1, GSTP1, and PTGS2. Conclusion. A variety of active ingredients of peach blossom regulate multiple signaling pathways by acting on targets, which reflects the characteristic of “multiple ingredients‐multiple targets‐multiple pathways,” thereby playing a role in the treatment of constipation.
An Improved Quantum-Behaved Particle Swarm Optimization Algorithm Combined with Reinforcement Learning for AUV Path Planning
Authors: Zhang HanBin , Shi XianPeng
Published: April 2023

In order to solve the problem of fast path planning and effective obstacle avoidance for autonomous underwater vehicles (AUVs) in two-dimensional underwater environment, a path planning algorithm based on deep Q-network and Quantum particle swarm optimization (DQN-QPSO) was proposed. Five actions are defined first: normal, exploration, particle explode, random mutation, and fine-tuning operation. After that, the five actions are selected by DQN decision thinking, and the position information of particles is dynamically updated in each iteration according to the selected actions. Finally, considering the complexity of underwater environment, the fitness function is designed, and the route length, deflection angle, and the influence of ocean current are considered comprehensively, so that the algorithm can find the solution path with the shortest energy consumption in underwater environment. Experimental results show that DQN-QPSO algorithm is an effective algorithm, and its performance is better than traditional methods.
Figure 3 from Novel Oncogenic Transcription Factor Cooperation in RB-Deficient Cancer
Authors: Mandigo Amy C. , Shafi Ayesha A. , McCann Jennifer J. , Yuan Wei , Laufer Talya S. , Bogdan Denisa , Gallagher Lewis , Dylgjeri Emanuela , Semenova Galina , Vasilevskaya Irina A. , Schiewer Matthew J. , McNair Chris M. , de Bono Johann S. , Knudsen Karen E.
Published: April 2023

Supplemental Figure 3
Supplementary Materials and Methods from Risk and Protective Factors for Cancer Mortality among United States Service Members and Veterans (2001–2018)
Authors: Sharifian Neika , Carey Felicia R. , Seay Julia S. , Castañeda Sheila F. , Boyko Edward J. , Rull Rudolph P.
Published: April 2023

Supplementary Materials and Methods
Data from Risk and Protective Factors for Cancer Mortality among United States Service Members and Veterans (2001–2018)
Authors: Sharifian Neika , Carey Felicia R. , Seay Julia S. , Castañeda Sheila F. , Boyko Edward J. , Rull Rudolph P.
Published: April 2023

AbstractBackground:
Prior research linking military factors with cancer-specific mortality has shown inconsistent findings, with few studies examining these associations among U.S. service members and veterans who served in Operation Iraqi Freedom/Operation Enduring Freedom conflicts.
Methods:
Cancer mortality between 2001 and 2018 was ascertained from the Department of Defense Medical Mortality Registry and National Death Index for 194,689 Millennium Cohort Study participants. Cause-specific Cox proportional hazard models were used to examine links between military characteristics and cancer mortality [overall, early (<45 years), and lung].
Results:
Compared with individuals who deployed with no combat experiences, non-deployers had a greater risk of overall [HR = 1.34; 95% confidence interval (CI) = 1.01–1.77] and early cancer mortality (HR = 1.80; 95% CI = 1.06–3.04). Enlisted individuals had a greater risk of lung cancer mortality compared with officers (HR = 2.65; 95% CI = 1.27–5.53). No associations by service component, branch, or military occupation and cancer mortality were observed. Higher education was associated with reduced overall, early and lung cancer mortality risk and smoking and life stressors were associated with elevated overall and lung cancer mortality risk.
Conclusions:
These findings are consistent with the healthy deployer effect in which military personnel who were deployed tend to be healthier than those who did not deploy. Further, these findings highlight the importance of considering socioeconomic factors, such as military rank, that may have long-term implications for health.
Impact:
These findings highlight military occupational factors that may predict long-term health outcomes. Additional work is necessary to investigate more nuanced environmental and occupational military exposures and cancer mortality.
Supplementary Methods S1 from Ultra High-Plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles
Authors: Bonnett Shilah A , Rosenbloom Alyssa B , Ong Giang T , Conner Mark , Rininger Aric BE , Newhouse Daniel , New Felicia , Phan Chi Q. , Ilcisin Saskia , Sato Hiromi , Lyssand John S , Geiss Gary , Beechem Joseph M.
Published: April 2023

Supplementary Methods S1: Protocol for proteogenomic workflow
Supplementary Table S1 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Table 1: Global proportional hazards test for exposure and covariates included in the model
Supplementary Figure S5 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 5: Race/ethnicity specific associations between Any T2D and BCA, with censorship of BCA cases that occurred
within 2 years of incident T2D as non-cases. Models adjusted for pack-years smoked (0, 1-10, 11-20, 21-30, 31-40, >40), alcohol
consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), number of cigarettes smoked per day among smokers
(5 cigarettes or less, 6-10 cigarettes, 11-20, 21-30, 31 or more), race/ethnicity (European American, African American, Japanese
American, Latin American, Native Hawaiian), and reproductive factors among females. Body mass index (BMI, kg/m3
) and smoking
status (ever, never, current) were included as strata variables due to their proportional hazard violation. Categorical birthyear was also
included as a strata variable to adjust for possible cohort effects. CI: Confidence Interval; HR: Hazard Ratio; P het: P- heterogeneity
for likelihood ratio test for difference in association across race/ethnicity groups.
Supplementary Figure S2 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 2: Surveillance, Epidemiology, and End Results Program stage distribution of bladder cancer cases by
race/ethnicity. 0: In situ: noninvasive, intraepithelial; 1: Localized only; 2: Regional by direct extension only; 3: Regional lymph node(s)
involved only; 4: Regional by BOTH direct extension AND regional lymph node(s) involved; 5: Regional, NOS; 7: Distant site(s)/lymph
node(s) involved; 8: Unknown if extension or metastasis; M: Missing.
Supplementary Figure S11 from Interethnic Differences in Bladder Cancer Incidence and the Association Between Type 2 Diabetes and Bladder Cancer in the Multiethnic Cohort Study
Authors: Bogumil David , Cortessis Victoria K. , Wilkens Lynne R , Le Marchand Loic , Haiman Christopher A , Maskarinec Gertraud , Setiawan Veronica Wendy
Published: April 2023

Supplementary Figure 11: Associations between Any T2D and BCA by race/ethnicity among never smokers. Models adjusted for
alcohol consumption (<1 drinks/month, ≤1 drinks/day, >1 drinks/day), sex (male, female), race/ethnicity (European American, African
American, Japanese American, Latin American, Native Hawaiian), and reproductive factors among females. Body mass index (BMI,
kg/m3
) was included as a strata variable due to a proportional hazard violation. Categorical birthyear was also included as a strata
variable to adjust for possible cohort effects. CI: Confidence Interval; HR: Hazard Ratio; P het: P- heterogeneity for likelihood ratio test
for difference in association across covariate levels.
Supplemental Figure 5 from Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer
Authors: Badesha Jasleen K. , Zhou Marilyn , Arif Arif A. , Gill Sharlene , Speers Caroline , Peacock Michael , De Vera Mary A. , Stuart Heather C. , Brown Carl J. , Donellan Fergal , Loree Jonathan M.
Published: April 2023

Supplemental Figure 5. Overall survival, disease-specific survival and disease-free survival by age group and treatment type in early-stage rectal cancers.
Supplemental Figure 4 from Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer
Authors: Badesha Jasleen K. , Zhou Marilyn , Arif Arif A. , Gill Sharlene , Speers Caroline , Peacock Michael , De Vera Mary A. , Stuart Heather C. , Brown Carl J. , Donellan Fergal , Loree Jonathan M.
Published: April 2023

Supplemental Figure 4. Disease-free survival (DFS) by age in early-stage rectal cancers. The Kaplan-Meier survival curves are shown for a period of 10 years. The survival curves begin to separate towards the end of the routine follow-up period of 5 years.
Supplemental Figure 1 from Treatment Patterns and Outcomes of Preoperative Neoadjuvant Radiotherapy in Patients with Early-onset Rectal Cancer
Authors: Badesha Jasleen K. , Zhou Marilyn , Arif Arif A. , Gill Sharlene , Speers Caroline , Peacock Michael , De Vera Mary A. , Stuart Heather C. , Brown Carl J. , Donellan Fergal , Loree Jonathan M.
Published: April 2023

Supplemental Figure 1. Consort diagram showing patient inclusion at each stage of analysis. Patient groups used in each stage of analysis are adjacent to the indicated analyses. Patients excluded at each stage of analysis are also indicated.
Data from Ultra High-Plex Spatial Proteogenomic Investigation of Giant Cell Glioblastoma Multiforme Immune Infiltrates Reveals Distinct Protein and RNA Expression Profiles
Authors: Bonnett Shilah A , Rosenbloom Alyssa B , Ong Giang T , Conner Mark , Rininger Aric BE , Newhouse Daniel , New Felicia , Phan Chi Q. , Ilcisin Saskia , Sato Hiromi , Lyssand John S , Geiss Gary , Beechem Joseph M.
Published: April 2023

Abstract
A deeper understanding of complex biological processes, including tumor development and immune response, requires ultra high-plex, spatial interrogation of multiple “omes”. Here we present the development and implementation of a novel spatial proteogenomic (SPG) assay on the GeoMx® Digital Spatial Profiler platform with NGS readout that enables ultra high-plex digital quantitation of proteins (> 100-plex) and RNA (whole transcriptome, > 18,000-plex) from a single FFPE sample. This study highlighted the high concordance, R > 0.85, and <11% change in sensitivity between SPG assay and the single analyte assays on various cell lines and tissues from human and mouse. Furthermore, we demonstrate that the SPG assay was reproducible across multiple users. When used in conjunction with advanced cellular neighborhood segmentation, distinct immune or tumor RNA and protein targets were spatially resolved within individual cell subpopulations in human colorectal cancer and non-small cell lung cancer. We used the SPG assay to interrogate 23 different glioblastoma multiforme samples across 4 pathologies. The study revealed distinct clustering of both RNA and protein based on pathology and anatomic location. The in-depth investigation of giant cell glioblastoma multiforme revealed distinct protein and RNA expression profiles compared to that of the more common glioblastoma multiforme. More importantly, the use of spatial proteogenomics allowed simultaneous interrogation of critical protein post-translational modifications alongside whole transcriptomic profiles within the same distinct cellular neighborhoods.
Psychotherapy for Chronic In- and Outpatients with Common Mental Disorders: The “Choose Change” Effectiveness Trial
Authors: Gloster Andrew T. , Haller Elisa , Villanueva Jeanette , Block Victoria , Benoy Charles , Meyer Andrea H. , Brogli Sandra , Kuhweide Veronika , Karekla Maria , Bader Klaus , Walter Marc , Lang Undine
Published: April 2023

Introduction: Treatment non-response occurs regularly, but psychotherapy is seldom examined for such patients. Existing studies targeted single diagnoses, were relatively small, and paid little attention to treatment under real-world conditions. Objective: The Choose Change trial tested whether psychotherapy was effective in treating chronic patients with treatment non-response in a transdiagnostic sample of common mental disorders across two variants of treatment delivery (inpatient and outpatient). Methods: The controlled nonrandomized effectiveness trial was conducted between May 2016 and May 2021. The study took place in two psychiatric clinics with N = 200 patients (n = 108 inpatients and n = 92 outpatients). Treatment variants were integrated inpatient care versus outpatient care based on acceptance and commitment therapy (ACT) for approximately 12 weeks. Therapists delivered individualized and non-manualized ACT. Main outcome measures were symptoms (Brief Symptom Checklist [BSCL]); well-being (Mental Health Continuum-Short Form [MHC-SF]), and functioning (WHO Disability Assessment Schedule [WHO-DAS]). Results: Both inpatients and outpatients showed decreases in symptomatology (i.e., BSCL: d = 0.68) and increases in well-being and functioning (MHC-SF: d = 0.60 and WHO-DAS: d = 0.70), with more improvement in the inpatients during treatment. Both groups maintained gains 1 year following treatment, and the groups did not significantly differ from each other at this timepoint. Psychological flexibility moderated impact of stress on outcomes. Conclusions: Psychotherapy as practiced under routine conditions is effective for a sample of patients with common mental disorders, a long history of treatment experience and burden of disease, in both inpatient and outpatient settings. Trial registration: This study was registered in the ISRCTN registry on May 20, 2016, with the registration number ISRCTN11209732.
Nutrition and Physical Activity in Cancer Patients
Authors: Papadopoulou Sousana
Published: April 2023

The diagnosis and treatment of cancer are associated with impairment at the physical and at psychological level. In addition, side effects are a potentially treatment-limiting factor that may necessitate dose reduction, delay, or even discontinuation of therapy, with negative consequences for outcome and mean survival. Numerous studies have shown that physical activity and sports and exercise therapy programs are not only practicable but also recommendable for oncologic patients during the acute phase and in the aftercare. Furthermore, nutrition plays an important role in all stages of tumor therapy. A timely integration of a nutrition therapy and physical activity in the form of physiotherapy and sports therapy serves to prevent and reduce treatment-associated side effects. Evidence-based recommendations on cancer prevention through nutrition therapy, physical activity, and sports and exercise therapy should be integrated into treatment plans for oncology patients as well as in health care services for the general population. Individual counselling by trained nutrition and exercise specialists may be advisable to receive concrete recommendations on the respective tumor entity or specific side effects. This mini review is based on a selective literature search in the PubMed database and Cochrane Central Register of Controlled Trials on the subjects of healthy diet and physical activity in primary prevention and follow-up about cancer.
Influence of Surgical Experience and Risk Factors for Surgical Failure in Primary Retinal Detachment Surgery
Authors: Kim Min Seok , Park Jun Young , Jin Ki Won , Park Kyu Hyung , Park Sang Jun , Joo Kwangsic , Woo Se Joon
Published: April 2023

Introduction: The aim of this study was to report surgical outcomes and risk factors for primary surgical failure following rhegmatogenous retinal detachment (RRD) repair. Methods: In this retrospective cohort study, RRD patients who underwent primary surgery at a tertiary center between January 1, 2006, and December 31, 2020, were enrolled. Surgical failure was defined as reoperation within 60 days postoperatively due to retinal re-detachment and putative risk factors for surgical failure were analyzed. Results: Of 2,383 eyes (2,335 patients), 1,342 (56.3%) underwent vitrectomy and 1,041 (43.7%) underwent scleral buckling. The surgical failure rate was 9.1% overall, and 6.0% and 13.1% for the vitrectomy and scleral buckling groups, respectively. In the multivariate logistic regression analysis, surgical failure was associated with surgical experience (first-year fellow vs. senior professor) (odds ratio [OR]: 1.66; p = 0.018), scleral buckling (OR: 2.33; p < 0.001), and longer axial length (AL; ≥26.5 mm) (OR: 1.49; p = 0.017). In each surgical approach, age <40 years (OR: 2.11; p = 0.029) in the vitrectomy group and age >40 years (OR, 1.84; p = 0.004), male sex (OR: 1.65; p = 0.015), and first-year fellows compared to senior professors (OR: 1.95; p = 0.013) in the scleral buckling group were associated with surgical failure. Lens status were not associated with the surgical failure rate. Conclusion: In this large retrospective study using data from Korea, vitrectomy was superior to scleral buckling in terms of primary anatomical outcomes in the management of RRD. First-year fellows were a risk factor for surgical failure, especially for scleral buckling. Longer AL was a significant parameter for predicting the success rates.
Setor elétrico: mimetismo, fragmentação e suas sequelas
Authors: D Araujo Roberto Pereira
Published: April 2023

This article attempts to show that the current crisis experienced by the Brazilian electrical sector is not only related to unexpected hydrological droughts. Although one needs to take into account the relatively severe hydric constraints, the critical signs had already been evidenced about four years ago. Despite the enormous differences of the Brazilian case, several misguided policies have been implemented here under strong inspiration of the type of market model adopted, influenced by a mimicry of thermal-based systems. This adaptation modeling generates a highly volatile market where paltry and priceless values come one after another. The crisis is far from being over, since the structural basis of the model is not being questioned.
Moral e ética no mundo contemporâneo
Authors: La Taille Yves de
Published: April 2023

We have chosen to give different and complementary definitions for the concepts of ethics and morals, for the sake of convention. The ethical question concerns “how to live” whereas the moral question regards “how we should act”. Thus, ethics concerns what makes up a “good life” while morals relates to one’s duties. That being said, here we analyse some ethical and moral characteristics of the contemporary world, in the light of a psychological framework, and reached the following two conclusions, among others: 1) that which we call “culture of vanity” weakens the construction of ethical personalities, a necessary condition for moral action; 2) that which we call “culture of boredom” jeopardizes the genuine pursuit of a “good life”; therefore, it also compromises the construction of ethical personalities
Impacto da correção cirúrgica dos membros inferiores na qualidade de vida de pacientes com a doença de Charcot-Marie-Tooth
Authors: Costacurta Maria Lucia Goffi , Sousa Pedro Paulo , Zuccon Alexandre , Morais Filho Mauro César de , Rocco Fernanda Moraes , Gaspar Alexandra Passos
Published: April 2023

Há poucos estudos sobre a reabilitação de pacientes com a doença de Charcot Marie. Estes pacientes apresentam sintomas da doença precocemente e têm sobrevida longa o que determina alterações biomecânicas que afetam a qualidade de vida dos mesmos e por esta razão o estudo de possíveis tratamentos para estes pacientes são de grande importância. A intervenção cirúrgica das extremidades inferiores é uma destas possibilidades. Apesar de não haver conclusões ainda sobre qual a técnica cirúrgica e se a mesma é o melhor tratamento, a mesma é realizada para melhorar a qualidade de marcha e qualidade de vida destes pacientes. O estudo tem então o objetivo de avaliar o impacto do procedimento cirúrgico na qualidade de vida dos pacientes com doença de Charcot Marie Tooth. Foram avaliados 9 pacientes antes e após procedimento cirúrgico através de análise do laboratório de marcha, questionário MFM e SF 36. Houve diferença significativa nas avaliações pré e pós operatórias no MFM e SF36. Neste estudo, a cirurgia corretiva de membros inferiores mostrou ter um impacto positivo na qualidade de vida dos pacientes com a doença de CMT, principalmente através da melhora do desempenho motor e da dor.
Confiabilidade do limiar de lactato identificada pelo método visual
Authors: Fonseca Sueli Ferreira da , Amorim Mateus Ramos , Arrieiro Arthur Nascimento , Peixoto Marco Fabrício Dias , Lopes Fernando Joaquim Gripp , Avelar Núbia Carelli Pereira , Lacerda Ana Cristina Rodrigues
Published: April 2023

Limiar de lactato (LL) tem sido utilizado como medidor de condicionamento físico, indicador sensível do estado do treinamento aeróbico em sujeitos saudáveis e doentes, além disso, auxilia na identificação do estímulo de treinamento ideal e na prescrição da intensidade de treinamento. O objetivo do presente estudo foi avaliar a confiabilidade intra e interexaminadores das medidas do LL obtidas através do método de detecção visual. Para isso, 31 voluntárias do sexo feminino (67,50 ± 4,41 anos; 1,52 ± 0,07 m; 64,55 ± 11,46 kg), aparentemente saudáveis e no período pós-menopausa, participaram do estudo. O LL foi determinado a partir de um teste realizado na esteira ergométrica até a fadiga, que consistiu de estágios com carga progressiva (variação da velocidade e/ou inclinação). Amostras de sangue foram coletadas por meio de uma punção na polpa digital do dedo médio a cada 3 minutos durante o teste. Em seguida, foram construídos os gráficos do método de detecção visual (software Prisma5) a partir da concentração de lactato sanguíneo coletado a cada estágio do exercício (intervalo de 3 minutos) em função da taxa de trabalho correspondente ao consumo de oxigênio (VO2) estimado durante o teste na esteira. A análise estatística foi realizada através do Coeficiente de Correlação Intraclasse (CCI). A confiabilidade intraexaminador foi excelente (0,950 - 0,952) e a confiabilidade interexaminadores foi boa (0,789 - 0,770). Dessa forma, sugere-se que o método de detecção visual é uma forma segura e confiável para detectar o LL na prática clínica e em pesquisas.
Efeitos da plataforma vibratória no equilíbrio em idosos
Authors: Silva Patrícia Zambone da , Schneider Rodolfo Herberto
Published: April 2023

O envelhecimento determina uma série de alterações fisiológicas, dentre elas, perda da massa muscular, diminuição do equilíbrio e dos reflexos posturais. Como conseqüência destas transformações, o risco de quedas aumenta, o que é um evento marcante, podendo instituir início do declínio da saúde no idoso. Diversas abordagens têm sido utilizadas na prevenção das quedas, sendo que, mais recentemente, a plataforma vibratória, tem sido avaliada para aumentar o equilíbrio e controle postural nos idosos, portanto reduzindo os riscos de quedas e suas conseqüências. Esta revisão bibliográfica tem como foco os artigos mais relevantes sobre o tema. Os resultados obtidos indicaram melhora do equilíbrio e controle postural nesta população quando comparada com exercícios, fisioterapia ou sedentarismo. No entanto, há inúmeros protocolos de treinamento diferentes, o que dificulta a comparação de resultados. Esta revisão demonstra que a plataforma vibratória é uma promissora intervenção na prevenção de quedas em idosos, porém são necessários mais estudos para determinar o protocolo mais adequado de tratamento para melhorar o equilíbrio.
Acompanhamento das funções respiratória e motora de crianças com atrofia muscular espinhal e distrofia muscular de Duchenne: um estudo longitudinal
Authors: Santos Cristina Maria , Wamosy Renata Maba Gonçalves , Sanada Luciana Sayuri , Schivinski Camila Isabel Santos
Published: April 2023

Objetivo: Realizar o acompanhamento de crianças e adolescentes com Atrofia Muscular Espinhal (AME) e Distrofia Muscular de Duchenne (DMD) em um centro de referência, por meio de avaliações de parâmetros respiratórios e motores. Métodos: Conduziu-se 3 avaliações em um período de 24 meses, em pacientes até 15 anos, com DMD e AME. Avaliações respiratórias incluíram: parâmetros cardiorrespiratórios, força muscular respiratória, pico de fluxo de tosse e espirometria. Analisou-se a função motora por meio de escalas especificas: 1) Children’s Hospital of Philadelphia Infant Test of Neuromuscular Disorders (CHOP INTEND) para crianças até 2 anos; 2) Medida da Função Motora (MFM-32) acima de 6 anos; 3) versão reduzida (MFM-20) para 2 a 6 anos. A análise estatística incluiu o teste de Shapiro-Wilk e utilizou-se ANOVA com Post Hoc de Bonferroni ou Friedman, e aplicou-se os coeficientes de Spearman ou Pearson. Resultados: Participaram 16 pacientes com mediana de idade de 6,5 anos, 12 com AME e 4 DMD. Houve diferença entre dados antropométricos, a frequência de crianças que não realizava fisioterapia reduziu (12,5%X6,3%) e houve aumento na adesão para técnica de empilhamento de ar (37,5%X43,8%). Uso de ventilação não invasiva se manteve igual, assim como parâmetros respiratórios e escalas motoras. Verificou-se forte correlação entre valor predito da capacidade vital forçada e escores MFM-20 e MFM-32. Conclusão: O acompanhamento ambulatorial de crianças com AME e DMD evidenciou relativa manutenção em parâmetros respiratórios e de função motora, o que pode ser atribuído a melhora na adesão de rotinas terapêuticas e aos cuidados em um centro de referência.
The concurrent validity of the Stroke Self-Efficacy Questionnaire Brazil (SSEQ-B) in brazilian stroke survivors
Authors: Deon Pedro Henrique , Loss Bianca Pacheco , Jaques Eliana da Silva , Urbanetto Janete de Souza , Makhoul Marina Portugal , Torriani-Pasin Camila , Mestriner Régis Gemerasca
Published: April 2023

The Stroke Self-Efficacy Questionnaire Brazil (SSEQ-B) is designed to assess the self-efficacy of functional performance after stroke. Objective: To evaluate the concurrent validity of the SSEQ-B in Brazilian stroke survivors in relation to gold-standard measures of instrumental and basic daily living activities as well as quality of life after stroke. Methods: The concurrent validity of the SSEQ-B was tested using the Frenchay Activity Index (FAI), Barthel Index (BI) and Stroke Specific Quality of Life Scale (SS-QOL). Descriptive statistics, the Spearman’s coefficient index, Intraclass correlation coefficient (ICC), Cronbach alpha and achieved post-hoc power (1-ß) analyses were conducted. Results: Seventy-five stroke survivors aged 66.64 ± 12.97 years were included in this study. Total scores from the SSEQ-B were strongly correlated with the FAI (ICC= 0.8 / r= 0.72 / 1-ß= 1.0) and BI (ICC= 0.68 / r= 0.68 / 1-ß= 0.99), but weakly correlated with SS-QOL (ICC= 0.46 / r= 0.65 / 1-ß= 0.94), which suggests stroke self-efficacy is more closely associated with instrumental and daily living activities than the quality of life. Conclusion: The SSEQ-B exhibits good concurrent validity with instrumental and daily living activities and could be useful when assessing stroke self-efficacy in Brazilians.
Permanent health education in the context of obesity: a scoping review
Authors: Magalhães Carolina Gusmão , Ceccim Ricardo Burg , Silva Lígia Amparo Santos da , Santos Verena Macedo , Pereira Emile Miranda , Santos Ana Artur Francisco Mussa , Júnior Gesner Franscisco Xavier , Martins Poliana Cardoso , Santana Mônica Leila Portela de
Published: April 2023

OBJETIVE: To map the international literature on Permanent Health Education initiatives to care for people with obesity. METHODS: In total, six databases were searched without any language or publication period restriction according to the Joana Briggs Institute manual for evidence synthesis and the Prisma extension for scoping reviews (Prisma-ScR). Articles were independently analyzed by four reviewers and data, by two authors, which were then analyzed and discussed with our research team. RESULTS: After screening 8,780 titles/abstracts and 26 full texts, 10studies met our eligibility criteria. We extracted data on methodologies, themes, definitions of obesity, outcomes, and gaps. Most initiatives came from North American countries without free or universal health systems and lasted a short period of time (70%), had multidisciplinary teams (70%), and addressed sub-themes on obesity approaches (90%). Results included changes in participants’ understanding, attitude, and procedures (80%) and gaps which pointed to the sustainability of these changes (80%). CONCLUSION: This review shows the scarce research in the area and a general design of poorly effective initiatives, with traditional teaching methodologies based on information transmission techniques, the understanding of obesity as a disease and a public health problem, punctual actions, disciplinary fragmentation alien to the daily work centrality, and failure to recognize problems and territory as knowledge triggers and to focus on health care networks, line of care, the integrality of care, and food and body cultures.
Importância da vacinação contra o papilomavírus humano em um assentamento rural em Terenos, Mato Grosso do Sul
Authors: Souza Zilda Alves de , Puga Marco Antonio Moreira , Tozetti Inês Aparecida , Lima Marcella Naglis de Oliveira , Souza Milena Sonchine de , Farias Marisa de Fátima Lomba de , Scandola Estela Márcia Rondina , Padovani Cacilda Tezelli Junqueira
Published: April 2023

OBJETIVO: Compreender as percepções dos profissionais de saúde acerca da vacinação contra o papilomavírus humano (HPV) no Complexo de assentamentos Santa Mônica, em Terenos, Mato Grosso do Sul. MÉTODOS: Foram utilizadas metodologias quanti-qualitativas, consultas em cartões vacinais, registros de agente comunitários de saúde e a técnica de grupo focal. Foram analisados os principais fatores de hesitação e recusa vacinal, bem como as estratégias da equipe de saúde para o processo de imunização contra o HPV, de junho a agosto de 2018. RESULTADOS: De 121 crianças e adolescentes, 81 (66,94%) receberam o esquema vacinal completo. A cobertura vacinal completa feminina foi de 73,17% (60/82) e a masculina de 53,8% (21/39). Observou-se que, embora sejam adotadas estratégias para a promoção da vacina, como ações volantes, o público encontra-se resistente devido ao conhecimento superficial sobre a vacina e sua utilização em faixa etária precoce, mostrando-se suscetível à influência negativa da mídia e aos tabus da sociedade. Além disso, dificuldades quanto ao uso do cartão do Sistema Único de Saúde e a escassez de profissionais também foram observadas. CONCLUSÃO: Os resultados justificam a cobertura vacinal abaixo da meta e reforçam a necessidade de fortalecimento da estratégia de saúde da família, bem como da educação permanente e continuada dos profissionais, a fim de aumentar a confiança dos pais e a adesão à vacinação.
DOCK2 Deficiency Attenuates Abdominal Aortic Aneurysm Formation—Brief Report
Authors: Guo Xia , Cai Dunpeng , Dong Kun , Li Chenxiao , Xu Zaiyan , Chen Shi-You
Published: April 2023

Background:

Abdominal aortic aneurysm (AAA) is a potentially lethal disease that lacks pharmacological treatment. Degradation of extracellular matrix proteins, especially elastin laminae, is the hallmark for AAA development. DOCK2 (dedicator of cytokinesis 2) has shown proinflammatory effects in several inflammatory diseases and acts as a novel mediator for vascular remodeling. However, the role of DOCK2 in AAA formation remains unknown.

Methods:

Ang II (angiotensin II) infusion of ApoE
−/−
(apolipoprotein E deficient) mouse and topical elastase-induced AAA combined with DOCK2
−/−
(DOCK2 knockout) mouse models were used to study DOCK2 function in AAA formation/dissection. The relevance of DOCK2 to human AAA was examined using human aneurysm specimens. Elastin fragmentation in AAA lesion was observed by elastin staining. Elastin-degrading enzyme MMP (matrix metalloproteinase) activity was measured by in situ zymography.

Results:

DOCK2 was robustly upregulated in AAA lesion of Ang II–infused ApoE
−/−
mice, elastase-treated mice, as well as human AAA lesions. DOCK2
−/−
significantly attenuated the Ang II–induced AAA formation/dissection or rupture in mice along with reduction of MCP-1 (monocyte chemoattractant protein-1) and MMP expression and activity. Accordingly, the elastin fragmentation observed in ApoE
−/−
mouse aorta infused with Ang II and elastase-treated aorta was significantly attenuated by DOCK2 deficiency. Moreover, DOCK2
−/−
decreased the prevalence and severity of aneurysm formation, as well as the elastin degradation observed in the topical elastase model.

Conclusions:

Our results indicate that DOCK2 is a novel regulator for AAA formation. DOCK2 regulates AAA development by promoting MCP-1 and MMP2 expression to incite vascular inflammation and elastin degradation.
Sleep Deprivation Promotes Endothelial Inflammation and Atherogenesis by Reducing Exosomal miR-182-5p
Authors: Li Xiao , Cao Ying , Xu Xinxin , Wang Chongyue , Ni Qingbin , Lv Xiang , Yang Chao , Zhang Zhaoqiang , Qi Xufeng , Song Guohua
Published: April 2023

Background:

Insufficient or disrupted sleep increases the risk of cardiovascular disease, including atherosclerosis. However, we know little about the molecular mechanisms by which sleep modulates atherogenesis. This study aimed to explore the potential role of circulating exosomes in endothelial inflammation and atherogenesis under sleep deprivation status and the molecular mechanisms involved.

Methods:

Circulating exosomes were isolated from the plasma of volunteers with or without sleep deprivation and mice subjected to 12-week sleep deprivation or control littermates. miRNA array was performed to determine changes in miRNA expression in circulating exosomes.

Results:

Although the total circulating exosome levels did not change significantly, the isolated plasma exosomes from sleep-deprived mice or human were a potent inducer of endothelial inflammation and atherogenesis. Through profiling and functional analysis of the global microRNA in the exosomes, we found miR-182-5p is a key exosomal cargo that mediates the proinflammatory effects of exosomes by upregulation of MYD88 (myeloid differentiation factor 88) and activation of NF-ĸB (nuclear factor kappa-B)/NLRP3 pathway in endothelial cells. Moreover, sleep deprivation or the reduction of melatonin directly decreased the synthesis of miR-182-5p and led to the accumulation of reactive oxygen species in small intestinal epithelium.

Conclusions:

The findings illustrate an important role for circulating exosomes in distant communications, suggesting a new mechanism underlying the link between sleep disorder and cardiovascular disease.