bluuebunny/crossref_metadata_2025 huggingface dataset:
Authors: Soolany Christian
Published: June 2023

Water pumps generally use a source of electricity from fossil fuels to generate electricity, one example is using electricity from the National Electric Company, one of the obstacles is a power outage which results in the water pump not being able to operate. To overcome this problem, by utilizing energy derived from sunlight captured by using solar panels as alternative energy to drive water pumps. The purpose of this research is to produce a water pump powered by sunlight and to find out the resulting water discharge and the time effectiveness of using the water pump. The method used in this study is experimental by installing a wireless remote control switch on the water pump which acts as a breaker/connector for the pump flow so that it can turn on and off up to a distance of 100 meters. This pump is equipped with a Controller 30 A output of 12 V with a tolerance value of ± 10% which functions to find the maximum power point due to weather changes so that the panel's maximum power point is according to conditions and a 12 V 60 A panel battery to back up the 12 V 180 Watt water pump. The panel used is 200 WP with a max power voltage of 21.2V and a max power current of 12.2 Ampere, a low voltage of 10.9 V, and a low current of 11.1 A. Based on research the panel pump produces an average water discharge at night of 1,411.032 L/hour with a voltage of 10.9 V and a day of 1,404.48 L/hour with a voltage of 12.9 V while the effectiveness of using the water pump at 12.00 WIB with the highest voltage of 21.2 V.
HUBUNGAN PERILAKU PEMBERIAN MP-ASI DAN KEJADIAN DIARE DENGAN STATUS GIZI ANAK USIA 6-24 BULAN DI RSIA PKU MUHAMMADIYAH CIPONDOH
Authors: Susanti Tazkiyyah Khanifah , Dewanti Lintang Purwara , Sitoayu Laras , Nuzrina Rachmanida
Published: June 2023

Based on RISKESDAS 2018, diarrhea prevalence in Banten was 7.5%. While national prevalence was 6.8%. Diarrhea is the number one causal of inpatients at Indonesian hospitals. Incorrect breastfeeding and complementary feeding practices were some causal of nutritional problems. Complementary feeding practices need a proper delivery time, frequency, type, foods amount, and how to made. This was due to mothers’ ignorance of benefits and the correct way of giving complementary feeding so that it affects the mother's attitude. This study aimed to know the correlation of complementary feeding practices and diarrhea incidence toward nutrition status for infants at 6-24 months of age at RSIA PKU Muhammadiyah Cipondoh. This is a descriptive quantitative study with cross-sectional approach using primary data through interview with questionnaire and Recall 24-Hours. Total sample of infants (6-24 months of age) were 80. Statistical data processed using chi-square test. Data statistically showed that the age of complementary feeding had pValue=0.589, frequency with pValue=0.193, total energy intake pValue=0.22, OR=0.754, total protein intake p=0.016, OR=4.952, texture pValue=0.341, portion pValue=0.009, and the incidence of diarrhea had pValue=0.079. There was a correlation between total energy intake, protein intake, and portion of complementary foods toward nutrition status at RSIA PKU Muhammadiyah Cipondoh.

Keywords: complementary feeding practices, diarrhea, nutrition status
HUBUNGAN ANTARA TINGKAT STRES DAN ASUPAN MAGNESIUM DENGAN KEJADIAN DISMENORE PRIMER PADA REMAJA PUTRI DI SMA DAN SMK BATIK SURAKARTA
Authors: Hapsari Zulaiha Anggi , Widiyaningsih Endang Nur
Published: June 2023

This study aimed to determine the correlation between stress levels and magnesium intake with the incidence of primary dysmenorrhea in adolescent girls at Surakarta Batik High School and Vocational High School. The type of research used was observational with a cross-sectional approach. Sampling using simple random sampling technique with 192 research subjects. Data collection on stress levels was obtained through the Perceived Stress Scale questionnaire for the last 1 month. Magnesium intake data was obtained by filling out the SQ-FFQ form for the last 3 months. Data on the incidence of primary dysmenorrhea was obtained through the WaLIDD questionnaire for the past 1 month. The results showed that 91.7% of respondents experienced primary dysmenorrhea, 63.5% experienced moderate stress and 59.4% had good magnesium intake. Based on the chi-square test analysis, there is a correlation between stress levels and the incidence of primary dysmenorrhea (p-value 0.024), but there is no correlation between magnesium intake and the incidence of primary dysmenorrhea (p-value 0.184).
Koordinasi Mata-Tangan dengan Keterampilan Dribbling Bola Basket: Apakah Saling Berhubungan?
Authors: B Putra Sastaman
Published: June 2023

Bola basket merupakan olahraga masyarakat atau kelompok yang membutuhkan keterampilan, kebugaran fisik dan kecepatan yang baik agar dapat melakukan teknik dribbling dengan maksimal. Akan tetapi tidak menutup kemungkinan banyak faktor pendukung yang mempengaruhi kemampuan dribbling seorang pemain. Penelitian ini bertujuan untuk membuktikan hubungan koordinasi mata-tangan dengan kemampuan dribbling bola basket. Dalam penelitian ini menggunakan metode deskriptif dengan jenis penelitian korelasional dan pendekatan kuantitatif. Teknik sampling dalam penelitian ini menggunakan total sampling mengikutsertakan semua siswa putra kelas VIII berjumlah 48 siswa. Instrumen penelitian yang digunakan yaitu test pengukuran koordinasi mata dan tangan menggunakan test lempar tangkap dan kemampuan dribbling menggunakan bola basket. Kemudian analisis data melalui uji prasyarat normalitas dan uji linieritas dibantu menggunakan aplikasi SPSS 26. Berikutnya melakukan Uji korelasi product moment. Hasil perhitungan korelasi koordinasi mata-tangan dengan keterampilan dribbling bola basket rxy=0,895 > 0,228 yang menunjukan adanya hubungan yang signifikan. Kesimpulan penelitian yaitu koordinasi mata-tangan dengan keterampilan dribbling bola basket pada siswa putra kelas VIII Sekolah Menengah Pertama Santo Fransiskus Asisi Pontianak Utara memiliki hubungan yang signifikan. Hasil penelitian ini dapat memberikan referensi baru tentang faktor pendukung kemampuan dribbling dalam permainan bola basket. Rekomendasi penelitian selanjutnya mengungkap hubungan keseimbangan atau reaksi dengan kemampuan dribling bola basket
Identifikasi Tingkat Kebugaran Jasmani Siswa Sekolah Dasar di Kecamatan Sugihwaras
Authors: Priadana Benny Widya , Suwandi Edi
Published: June 2023

Kebugaran jasmani merupakan salah satu indikator capaian pembelajaran pada mata pelajaran pendidikan jasmani yang juga berpengaruh terhadap tingkat kualitas hidup siswa. Tujuan penelitian ini adalah untuk mengetahui kondisi kebugaran jasmani siswa sekolah dasar di kecamatan Sugihwaras kabupaten Bojonegoro. Metode penelitian yang digunakan adalah survey. Sebanyak 112 (56 laki-laki dan 56 perempuan) menjadi subjek penelitian ini. Instrumen penelitian ini menggunakan Plank dan PACER Test. Analisis data menggunakan deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa kebugaran otot dan kardiovaskular siswa laki-laki lebih baik dibanding dengan siswa perempuan. Namun, kebugaran kardiovaskular baik siswa laki-laki dan siswa perempuan sebagian besar berada dalam tingkat pemula dan berkembang. Oleh karena itu, sekolah, stakeholder, dan guru pendidikan jasmani perlu lebih memfasilitas siswa agar dapat berkativitas jasmani di waktu luang atau ketika istirahat, melakukan pengukuran kebugaran jasmani secara berkala dan meciptakan pembelajaran meaningful dipadukan dengan permainan berorientasi kebugaran yang inovatif
Pengaruh Latihan Circuit Training Terhadap Kecepatan Lari Jarak Pendek 100 Meter
Authors: Anisa Yunda , Aryanti Silvi , Bayu Wahyu Indra
Published: June 2023

Kecepatan sangat dibutuhkan dalam cabang olahraga lari jarak penek 100 meter. Tujuan dari penelitian ini adalah untuk mengetahui pengaruh metode circuit training terhadap hasil lari jarak pendek 100m siswa putra peserta ekstrakurikuler olahraga di MAN 1 Ogan Ilir. Penelitian ini meliputi metodologi kuantitatif, pendekatan quasi-eksperimental, dan desain kelompok pretest-posttest. Tiga puluh siswa MAN 1 Ogan Ilir yang mengikuti ekstrakurikuler atletik menjadi sampel penelitian ini. Tes yang digunakan adalah tes sprint 100m. Setelah sesi pelatihan enam minggu, teknik pelatihan sirkuit digunakan sebagai pengobatan dalam penelitian ini. Temuan uji-t sampel berpasangan, yang dilakukan dengan menggunakan SPSS versi 26, dan menghasilkan nilai signifikan 0,00 dengan nilai 0,05, menunjukkan hal ini. Dengan demikian, berdasarkan temuan sig. 0,00 0,05, ditentukan menolak Ho dan menerima Ha. Dengan demikian dapat disimpulkan bahwa circuit training mempengaruhi seberapa baik kinerja siswa putra yang mengikuti kegiatan ekstrakurikuler di MAN 1 Ogan Ilir pada lari jarak pendek 100m
PELAFALAN BAHASA INGGRIS OLEH PEGAWAI CUSTOMER SERVICE BANDARA INTERNASIONAL ADI SOEMARMO SURAKARTA
Authors: Fajri Amalia Ramadhani , Hadiningrum Indriyati
Published: June 2023

This article is written based on a job training done at the international airport of Adi Soemarmo. The focus is to figure out the English pronunciation of the customer service staff when they help tourists find information. The data is collected by observation, interview, and literary study. The result shows that, in general, foreign tourists are happy when the customer service staff can communicate using the English language. However, the staff still find problems especially when tourists cannot speak English or when seeing unfriendly tourists. Thus, it is suggested that the customer service staff keep improving their English skills and behave in a pleasant way to tourists.
ENGLISH PROMOTION ON INSTAGRAM TO PROMOTE SERULINGMAS BANJARNEGARA INTERACTIVE ZOO
Authors: Amirawati Ika , Puspitasari Indah
Published: June 2023

The purposes of this study is to make English promotion content on Instagram account @serulingmas_zoo, to know the problem and to overcome the problems in making English promotion content on Serulingmas Banjarnegara Interactive Zoo’s official Instagram account. The data was collected through direct practice method, observation method, documentation method and interview method. There were five contents uploaded on Instagram, three photos in the feed, one video in the feed and one Insta story which includes bilingual promotion content. Several obstacles found in the making English promotion on Instagram such as writing short captions that include all the information needed, choosing the diction and writing bilingual captions. However, there are also solutions to overcome those problems such as writing effective sentences, looking for references and using conversational sentences. The engagement of English promotion on Instagram increased. It can be seen from the increasing number of likes in the posts.
PENERJEMAHAN BROSUR LAYANAN KEIMIGRASIAAN BERBAHASA MANDARIN DI KANTOR IMIGRASI KELAS I TPI YOGYAKARTA
Authors: Zain Adella Amira , Tjaturrini Dyah
Published: June 2023

Tulisan berjudul “Penerjemahan Brosur Layanan Keimigrasian Berbahasa Mandarin Di Kantor Imigrasi Kelas 1 TPI Yogyakarta”, merupakan hasil egiatan praktik kerja yang dilakukan di Kantor Imigrasi Kelas I TPI Yogyakarta, pada tanggal 11 Januari – 16 April 2021. Praktik kerja ini bertujuan untuk menerjemahkan brosur layanan keimigrasian dari bahasa Indonesia ke bahasa Mandarin. Metode pengumpulan data yang digunakan oleh penulis adalah metode observasi partisipan, studi pustaka,  jelajah internet, dan wawancara. Dalam proses penerjemahan penulis menggunakan metode adaptasi sebagai metode utama dan metode harfiah sebagai metode pendukung. Ada tiga tahap dalam melaksanakan penerjemahan yaitu tahap analisis, tahap transfer, dan tahap restrukturisasi. Hasil dari kegiatan praktik kerja ini penulis adalah berupa terjemahan brosur layanan keimigrasian dari bahasa Indonesia ke bahasa Mandarin di Kantor Imigrasi Kelas I TPI Yogyakarta . Penerjemahan brosur ini bertujuan sebagai upaya meningkatkan pelayanan wisatawan asing China.
PENGGUNAAN BAHASA INGGRIS DI BAGIAN IZIN TINGGAL DI KANTOR IMIGRASI CILACAP
Authors: Febriyanti Betriana , Puspitasari Indah , Sari Rosdiana Puspita
Published: June 2023

The purpose of this study were to find out the use of English in the stay permit section, and to find out the solution to deal with the obstacles of using English in the stay permit section to improve the quality of information services in the immigration office. The Author use several methods such as observation, literature studies, and interviews. The use of English in the stay permit information service is good enough but there are some additions so that the information to be conveyed can be fully conveyed by by giving information about stay permit requirements, immigration stay permit flow, and to fill out the forms. The obstacles and solutions such as limitations in international language, and information. The solution to this problem is to increase vocabulary, often practice listening to the accents of other countries, and using body language. The second is a limitation of information is by finding out in conveying information to provide good and clear information to visitors.
TRANSLATING ANIMATION BY EKI N. F., DEDDY OTARA, AND ZULFA ASLIHA ENTITLED “EYANG HABIBIE” ADIT AND SOPO JARWO
Authors: Cahyana Lanang Mahardhika , Setiawan Kristianto , Sudja’ie Mimien Aminah
Published: June 2023

This article is entitled Translating Animation by Eki N. F., Deddy Otara, and Zulfa Asliha entitled “Eyang Habibie” Adit Sopo Jarwo. The purpose of translates Adit Sopo Jarwo’s animation"Eyang Habibie" into English because it presents many cultures in Indonesia and the important aspect of this animation movie is how they respect each other’s differences in their cultures. Therefore, this animation is an interesting object to be translated so as to be enjoyed by foreign viewers. In the process of translating there were several obstacles which included, translator’s limited knowledge of vocabulary in the target language and source language, difficulty in determiningthe equivalent of words in the Target language to be communicative, and difficulty in using "aegisub" subtitle application to equate what the characters say with the subtitles. Anyway, they were solved by using a dictionary to find out words/vocabularies that were not understood, searching the equivalent in the Target Language and then consulting with the proofreader to determining the communicative equivalent then using it in the Target language and also learning about the features available in subtitle application called "aegisub".
DESIGNING ENGLISH VISITING BANYUMAS APPLICATION TO PROMOTE TOURIST DESTINATIONS
Authors: Aliyah Jannatin , Mariasari Septi , Dodiyanto Rosyid
Published: June 2023

This job training report was entitled “Designing English Visiting Banyumas Application to Promote Tourist Destinations”. The writer conducted job training started on Monday, February 1st, 2021, to Sunday, February 28th, 2021. The purpose of implementing the job training was to help the Banyumas Tourism, Sport, and Youth Office create a tourism promotion strategy in digital form. Banyumas has many beautiful tourist objects that were still not widely known by the public. Therefore, an application called Visiting Banyumas was created. This android-based application was created to make it easier for the public to get complete information about tourist attractions that are effective, massive, fast, and cheap.The method of making this application used the Waterfall method. This method could also be referred to as a linear sequential model or a classical life cycle. The approach used was a software approach sequentially starting from analysis, design, construction, testing, and maintenance. The implementation of this job training resulted in the Visiting Banyumas application, which could be downloaded for free on the Google Play Store. Six important aspects in the application are tourist objects and their history, tourist villages, culture, art, culinary, tourism, admin phone numbers, accommodation, and directions. All of these aspects contained titles, photos, and complete explanations. The latest news is contained in the application. The bookmark feature in the application could also help users to more easily access the application. This application is expected to help attract tourists to visit the Banyumas area. In addition, this application also uses English, which could be easily accessed and understood by foreign tourists. That is way, it could increase the number of foreign tourists who wanted to enjoy some of the beautiful places in Banyumas.
Analisis Beban Kerja Mental pada Marketing Menggunakan Metode NASA-TLX (Studi Kasus di Perusahaan XSMK)
Authors: Worldailmi Elanjati , Prabaswari Atyanti , Rojab Bagus Widianto
Published: June 2023

Perusahaan XSMK merupakan salah satu perusahaan yang bergerak di bidang produksi furnitur. Departemen Marketing berperan penting dalam peningkatan penjualan produk pada perusahaan ini. Departemen Marketing pada saat PPKM diwajibkan untuk melakukan pekerjaan dari rumah kini diharuskan untuk kembali aktif bekerja di kantor ditambah dengan tuntutan harus memenuhi target penjualan di perusahaan, yaitu harus mendapatkan keuntungan lebih tinggi dari tahun sebelumnya.  Oleh karena itu, peneliti melakukan penelitian dengan menggunakan metode NASA-TLX agar dapat melakukan pengukuran beban kerja mental pada karyawan bagian departemen marketing sehingga dapat diberikan rekomendasi yang berkaitan dengan beban kerja mental agar dapat meningkat efektivitas kerja karyawan. Hasil penelitian menunjukkan bahwa seluruh operator memiliki tingkat beban kerja mental dengan klasifikasi cukup tinggi hingga tinggi yang disebabkan oleh beragam factor antara lain Temporal Demand (TD) pada operator 1, Effort (EF) pada operator 2, dan Mental Demand (MD) untuk operator 3 dan 4. Rekomendasi perbaikan pekerjaan antara lain menyesuaikan beban kerja mental dengan kapasitas kerja dan kemampuan operator yang bersangkutan, menyesuaikan jam kerja terhadap tuntuan target harian karena menimbang banyak juga tuntutan di luar pekerjaan, memberikan kesempatan pada operator untuk mengembangkan kemampuannya.
Biofilm Adhesion and Micromorphology Analysis After Professional Oral Hygiene Procedures on Cad/Cam Milled and Veneered Zirconia Restorations – In Vitro Study
Authors: Perić Mirjana , Čairović Aleksandra , Špadijer Gostović Aleksandra , Stanimirović Dragan , Kostić Marina , Ivanov Marija , Ćirić Ana , Glamocija Jasmina , Pavlovic Vladimir B.
Published: June 2023

Objective: The purpose of this study was to evaluate the surface texture and biofilm adhesion of veneered or CAD/CAM milled zirconia (partially stabilized with yttrium) after professional oral hygiene procedures.
Samples (4x4 mm, thickness 2 mm; n = 72) were separated from zirconia blanks (3Y-TZP-LA). One group was veenired with ceramics and the other group of samples was CAD/CAM milled. Each group had 2 subgroups: polished and glazed. The samples were subjected to simulated strokes of professional brushing using abrasive paste and ultrasonic scaling. Parameters of surface micromorphology and receptivity to biofilm were calculated before and after simulating the given methods of professional maintenance of oral hygiene. The characteristics of zirconia surface were evaluated by scanning electron microscopy (SEM). Microbial bacterial/fungal species (Staphylococcus aureus, Streptococcus sanguinis and Candida albicans) were used and cultured on the respective sterilized zirconia surfaces. The amount of biofilm formation on zirconia surface was quantified by colony forming unit (CFU) counts.
Results: SEM analysis showed the greatest change in surface microtopography after the use of ultrasonic scaling, in glazed zirconia samples. Less formation of colonies on the surface CAD/CAM milled zirconia restorations was observed.
Conclusion: Routine methods of professional maintenance of oral hygiene can damage the surface of glazed zirconia restorations.
Cellular Automata Modeling as Tool in The Corrosion Management
Authors: Reinoso-Burrows Juan C. , Cortés-Carmona Marcelo , Pineda Fabiola , Henriquez Mauro , Toro Norman , Galleguillos Madrid Felipe M.
Published: June 2023

Cellular automata (CA) models have emerged as a valuable tool in corrosion management. This manuscript provides an overview of the application of cellular automata models in corrosion research, highlighting their benefits and contributions to understanding the complex nature of corrosion processes. Cellular automata models offer a computational approach to simulate corrosion behavior at the microscale, capturing the intricate interactions between electrochemical reactions, material properties, and environmental factors generating a new vision of predictive maintenance. It discusses the key features of cellular automata, such as the grid-based representation of the material surface, the definition of state variables, and the rules governing cell-state transitions. The ability to model local interactions and emergent global behavior makes cellular automata particularly suitable for simulating corrosion processes. Finally, cellular automata models offer a powerful and versatile approach to studying corrosion processes, expanding models that can continue to enhance our understanding of corrosion and contribute to the development of effective corrosion prevention and control strategies.
Characteristics of Soto, an ethnic food that reflects Indonesian diversity: Based on ingredients
Authors: Cempaka Laras , Rizki Afifah Amalia , Asiah Nurul , David Wahyudi , Ramadhan Kurnia , Mukaromah Arnia Sari , Pramastya Hegar , Husain Fadly , Huda Nurul
Published: June 2023

Indonesia is highly diverse in culture, ethnicity, religion, and natural resources. The diversity is also obvious in its cuisine. Soto is an example of an iconic Indonesian dish found in many parts of the country. Despite sharing a similar name, the recipes vary according to their place of origin. Until now, how many variants of Soto are in Indonesia is not exactly known. This review aimed to discuss the characteristics of Soto based on ingredients. Soto is a soup composed of spices-flavored broth and various solid ingredients, such as vegetables and protein-and carbohydrate-rich foods. Every region in Indonesia has a different recipe of Soto; some use non-turmeric soup or coconut milk soup. The carbohydrate ingredients are mainly soun (cellophane noodle) and potato. The protein ingredients are mainly composed of chicken, egg, and beef. Vegetables consist of bean sprouts, tomatoes, and cabbage. Fried garlic, shallot, spring onion, and crackers are added as a garnish. The diversity of the ingredient makes the distinction among Soto: diversity of locality and diversity of ingredients. Approximately 46 types of Soto are reviewed in this article. Most of the Soto recipes use chicken, bean sprouts, soun, boiled egg, garlic, white pepper, red onion, ginger, and bay leaf as the main ingredients. Soto becomes an identity of its geographical origins and has distinction based on the main recipes.
Selamatan Bersih Desa sebagai Wujud Ucapan Syukur dalam Kontradiksi Budaya Jawa: Jaman Dahulu dan Sekarang
Authors: Nuraseh Sita
Published: June 2023

In ancient times, the majority of Javanese people still carried out the culture or tradition of salvation. This research uses the tradition or clean culture of the village or also known as merti desa as the object of research. Village cleaning is an activity that is a symbol of public gratitude to God Almighty for all His gifts. This gift can be in the form of anything such as sustenance, safety, harmony and peace. However, along with the development of the era and cultural acculturation, there have been cultural changes in the present era, including changes in the culture of clean village salvation. Cultural changes in society are usually caused by the community itself, or come from immigrant communities. The purpose of this research is to provide information about Javanese society, Javanese culture, and the tradition of village clean salvation. This study used descriptive qualitative method. The results of this study indicate that there have been several changes in the implementation of the village clean salvation tradition. The implementation in ancient times is more complete when compared to the implementation today.
Nilai Pendidikan dalam Antologi Geguritan Piweling Karya Devika Herfianingtyas
Authors: Muhamad Hikmatun Nazilah , Saddhono Khundaru , Sulaksono Djoko
Published: June 2023

The purpose of this study is to describe and explain the educational value contained in  the  piweling geguritan anthology by Devika Herfianingtyas. This research is a qualitative descriptive research with a content analysis approach. The data in this study is in the form of words, phrases, or sentences in the  piweling geguritan anthology by Devika Herfianingtyas. The data sources are in the form of documents, namely piweling anthology books, reference books, and relevant journals. The sampling technique in this study uses purposive sampling which is carried out selectively by selecting words, phrases, or sentences in the  Piweling geguritan anthology  that can represent the answer to the problem formulation that has been made. The data collection technique in this study was carried out by analyzing the educational value in  the piweling geguritan  anthology by Devika Herfianingtyas. The data analysis technique used in this study is an interactive analysis consisting of data collection, data reduction, data presentation, and conclusion drawing. Based on the results of the analysis, the educational values found in  Devika Herfianingtyas' anthology of Piweling geguritan are religious values, moral values, social values, and cultural values.
Dehydroascorbic acid sensitizes cancer cells to system xc- inhibition-induced ferroptosis by promoting lipid droplet peroxidation.
Authors: Barahona María José , Vera Matías , Stockwell Brent , Nualart Francisco , Ferrada Luciano
Published: June 2023

Since the discovery of ferroptosis, it has been postulated that this type of cell death could be utilized in treatments for cancer. Unfortunately, several highly aggressive tumor models are resistant to the pharmacological induction of ferroptosis. However, with the use of combined therapies, it is possible to recover sensitivity to ferroptosis in certain cellular models. Here, we discovered that co-treatment with the metabolically stable ferroptosis inducer imidazole ketone erastin (IKE) and the oxidized form of vitamin C, dehydroascorbic acid (DHAA), is a powerful therapy that induces ferroptosis in tumor cells previously resistant to IKE-induced ferroptosis. We determined that DHAA and IKE + DHAA delocalize and deplete GPX4 in tumor cells, specifically inducing lipid droplet peroxidation, which leads to ferroptosis. Moreover, in vivo, IKE + DHAA has high efficacy with regard to the eradication of highly aggressive tumors such as glioblastomas. Thus, the use of IKE + DHAA could be an effective and safe therapy for the eradication of difficult-to-treat cancers.
SARS-Cov2 seasonality and adaptation are driven by solar activity.
Authors: Gonzalez-Lugo Octavio
Published: June 2023

Since its isolation in Wuhan SARS-Cov2 showed a high mutation rate hindering the ability to properly characterize. Also as a consequence of its size, traditional sequence analysis methods were computationally constrained. However, applying variational autoencoders (VAEs) to custom sequence representations results in a series of clusters sorted by the sunshine duration (SD) rate of change (SDRC) and other solar-derived features. The transition between clusters is characterized by changes in viral genome size, apparent deletions can be found throughout the SARS-Cov2 genome. This series of deletions might behave as an internal clock inside the genome. SDRC-derived features synchronize COVID-19 cases into a single period. Both SDRC-derived features and solar features correlate with COVID-19 cases pointing towards a solar-dependent seasonality. Atmospheric changes that affect solar radiation also showed a correlation with COVID-19 cases. Analyzing viral genome composition as time series displays an attractor-like behavior under different solar-derived time scales. While clustering them by environmental conditions shows a similar pattern as the one found by the VAE models. Further development of analysis techniques will help us to better understand the seasonality and adaptation of pathogenic organisms.
Multisensory Stimulation Bundles on Sleep and Neurobehavioral Development in the First Year After Birth in Very Preterm Infants: A Randomized Crossover Controlled Study Protocol
Authors: Tang Xiaoli XIAO , Sha Sha , Shen Nanping , Zhu Zhiyu , Qin Yanmin , Shen Junyi , Bei Fei
Published: June 2023

Background
This paper is a protocol for an evaluator-blinded, randomized crossover trial. It aims to assess the sleep efficiency of hospitalized very preterm infants (VPIs) by providing multisensory stimulation bundles. In addition, it will observe the intervention impacts on sleep during hospitalization and the sleep and neurodevelopmental outcomes during the first year of post-discharge follow-up.
Methods
The study will be conducted in the neonatology department of a tertiary pediatric teaching hospital. All eligible VPIs will undergo two types of care in random order: “standard care” (2 weeks) and “standard care plus multisensory stimulation bundles” (2 weeks). A generated list of random numbers will be used for case sequence allocation. Sleep outcomes will be evaluated using the Actiwatch-2 Actigraph. Moreover, the amplitude-integrated electroencephalography and the Griffiths Mental Development Scales will be used to measure the neurodevelopmental outcomes during hospitalization and in the first year of follow-up of VPIs.
Discussion
The intervention protocol of this study differs from other traditional interventions by producing precise and consistent supportive stimulations, similar to the maternal tactile, auditory, posture, and visual effects for hospitalized preterm infants. This protocol could be an effective measure to facilitate sleep and early neurodevelopment of VPIs. The expected outcomes will help confirm implementing and generalizing of the multisensory stimulation bundles care protocol in neonatology departments. We expect the study to positively impact hospitalized VPIs, specifically for their sleep and early neurodevelopmental outcomes. The study will also provide a new perspective regarding parent and infant interaction strategies, particularly for newborn intensive care units that limit visits due to the global spread of COVID-19.
Trial registration:
Chinese Clinical Trial Registry (Registry Number: ChiCTR 2200059099), Registered 25 April 2022, https://www.chictr.org.cn/showproj.html?proj=166980
PARP-inhibitors Improve Progression-Free Survival in Breast Cancer Patients with Previous Platinum Exposure – A Systematic Review and Meta-Analysis
Authors: Pessoa Beatriz , Brandao Gabriela , Silva Caroliny Da , Gatof Emily , Yadav Siddhartha , Ernst Brenda , Mina Lida , Couch Fergus , Wulf Gerburg , Tung Nadine , Batalini Felipe , Marinho Alice
Published: June 2023

Importance:
The poly-adenosine diphosphate–ribose polymerase (PARP) enzymes are important for DNA single-strand break repair and PARP inhibitors (PARPi) cause an accumulation of unresolved DNA damage in tumors with BRCA1/2 mutations, resulting in cell death. However, because platinum salts also ultimately cause double-strand DNA breaks and may have overlapping mechanisms of resistance with PARPi, the efficacy of PARPi in patients with prior platinum therapy is unknown.
Objective
We sought to evaluate the efficacy of PARPi in patients with BRCA1/2-related breast cancer and previous platinum exposure.
Data Sources:
PubMed, Embase, and Cochrane Central Register of Controlled Trials databases were searched for papers up to June 26, 2022.
Study Selection:
We performed a systematic review and meta-analysis of studies that evaluated the efficacy of PARPi in patients with advanced or metastatic breast cancer and germline BRCA1/2 mutations. Two independent investigators identified double-blind, randomized controlled trials (RCTs) that included the subgroup of previous exposure to platinum.
Data Extraction and Synthesis:
Data extraction from published reports and quality assessment were performed under Cochrane recommendations. The software Review Manager 5.3 was selected for conducting the statistical analyses.
Main Outcome(s) and Measure(s):
The primary endpoint of interest was progression-free survival (PFS). Hazard ratios (HRs) with a 95% confidence interval (CI) were pooled, and a p-value of < 0.05 was considered statistically significant.
Results
From 2,069 database results (487 on PubMed; 1,376 on Embase; and 206 on Cochrane), 42 studies were fully reviewed, and 4 RCTs (total of 249 patients) were included in the final investigation. The PARPi included were Olaparib, Talazoparib, Niraparib, and Veliparib. Pooled analysis showed that PARPi improved PFS in breast cancer patients with prior treatment with platinum-based therapy compared to the control group [HR = 0.72; 95% CI, 0.53–0.97; p = 0.03]. For comparison, the population without previous platinum exposure had a similar magnitude of benefit from PARPi [HR = 0.68; 95% CI, 0.52–0.89; p = 0.005].
Conclusions and Relevance:
Despite the concerns about cross-resistance between PARPi and platinum agents, patients with advanced breast cancer and previous exposure to platinum therapy have a longer PFS with PARPi when compared to standard chemotherapy.
Endothelial progenitor cell-derived exosomal miRNA-31 alleviates septic peritonitis by inhibiting E-selectin expression: an investigation on the mechanism of action
Authors: Liu Shaoguang , Zhang Shaotong , Wang Bo , Zhou Wence
Published: June 2023

Purpose: The critical role played by miRNAs in sepsis-induced acute peritonitis has been repeatedly validated. This research focuses on elucidating the influence of endothelial progenitor cells (EPC)-derived exosomal miRNA-31 (exo-miR-31) on septic peritonitis (SP) and the role of E-selectin (SELE) in this process.
Methods: Differences in serum miRNA-31 and soluble SELE (sSELE) expression between SP cases and healthy controls (HCs) were identified. Additionally, we built a mouse colon ascendens stent peritonitis (CASP) model and an in vitro sepsis model via lipopolysaccharide (LPS) stimulation of mouse venous endothelial cells to verify the specific mechanism of EPC-derived exo-miR-31 on SP in vitro and in vivo.
Results: As indicated by enzyme-linked immunosorbent assay (ELISA) and quantitative real-time polymerase chain reaction (qRT-PCR) results, SP cases showed markedly reduced serum miR-31 levels and evidently elevated sSELE expression than HCs, with the expression of both genes altered more significantly as the condition worsened. Correlation analysis suggested a strong association between serum miRNA-31 and sSELE levels and sepsis severity. miR-31 in the peritoneal lavage fluid (PLF) of CASP model mice was down-regulated, while sSELE and inflammatory factors (IFs) TNF-α, IL-6 and IL-10 were notably increased. Gimsa staining revealed the massive recruitment and aggregation of nucleated cells in the abdominal cavity of CASP mice, and HE staining showed extensive neutrophilic infiltration in lung, liver and colon tissues, with obvious inflammatory tissue destruction. Besides, large numbers of bacteria were detected in the peripheral blood and PLF of CASP mice, with many CASP mice dying within 48 hours, as indicated by the bacterial smears and culture tests. EPC-derived exo-miR-31 was effective in elevating PLF miR-31 expression in CASP mice while suppressing sSELE, TNF-α, IL-6 and IL-10 levels. In EPCs-ExosmiR-31 group, significant reductions in nucleated cell counts in the mouse PLF, neutrophil infiltration in lung, liver and colon tissues, and peripheral blood and PLF bacterial loads were observed, as well as an obvious extension in survival. In addition, in vitro experimental results of cell sepsis showed that miR-31 could obviously block the inhibitory effect of LPS stimulation on the proliferation level of mouse venous endothelial cells and inhibit the level of apoptosis. SELE, Caspase-3 and Bax protein levels were markedly lower in LPS+miR-31 group as compared to LPS and LPS-miR-NC groups, while Bcl-2 was increased (P<0.05). Dual luciferase reporter gene assay identified the role of miR-31 as the direct target of SELE.
Conclusions: EPC-derived exo-miR-31 can effectively alleviate SP, possibly through targeted inhibition of SELE, providing a potential new direction for future prevention and treatment of SP.
Improved KW entropy: a complexity measurement technique for time-series and its application in feature extraction of quay crane gearbox
Authors: Gu Chunxia , Bi Juan , Wang Bing
Published: June 2023

The working environment of the quay crane is harsh and special. As an important transmission equipment of hoisting mechanism, health condition of gearbox is very important for reliable operation. In order to extract degradation features from complex vibration monitoring signals, an improved KW symbol entropy feature extraction technique is proposed. Considering the unity of symbol standard, the method takes the root mean square of the normal condition signal as the symbol standard and combines the symbol coefficient to construct a unified symbol scale. At the same time, symbols number variable is introduced to expand symbols set and improve the information expressing ability. On this basis, combining with information entropy theory, complexity of symbol sequence in symbol sequence and symbol distribution is calculated respectively, and two features named improved symbol sequence entropy (IKSE) and improved symbol distribution entropy (IKDE) are obtained. The Logistic chaotic sequence and the lifetime signal of the hoisting gearbox are used for analysis respectively. The result show that the proposed features are able to characterize the complexity of nonlinear time series, so as to describe the whole process of the performance degradation of the hoisting gearbox sensitively. The parameters have little influence and the technique have a good stability.
A controlled clinical study on efficacy and safety of periocular triamcinolone acetonide injection for treating ocular myasthenia gravis
Authors: Shi Minghua , Lu Zhuneng , Qin Aijiao , Cheng Jing , Chen Simin , Xing Yiqiao
Published: June 2023

OBJECTIVE
To evaluate the efficacy and safety of peribulbar triamcinolone acetonide injection for treating ocular myasthenia gravis (OMG), with a comparison of traditional oral drug therapy.
METHODS
A total of 22 patients with OMG who received periocular triamcinolone acetonide injection (initially 20mg weekly, then once per month later if symptoms were improved) from July 2019 to July 2022 were evaluated by a comparison of symptom degree before and after treatment. Adverse reactions were also monitored during the period of treatment. The period of follow-up was more than 6 months. Additionally, a comparison of the treatment efficacy between this periocular injection and traditional oral administration was performed in OMG patients.
RESULTS
After 4 weeks of treatment, the degree of ptosis in OMG patients decreased to -3.00 ± 0.69, compared to the value (-0.86 ± 1.32) before treatment. The degree of ophthalmoplegia also decreased from 3.12 ± 0.72 to 0.86 ± 0.88 (P<0.001) after treatment. The achievement rates of minimal manifestations status (MMS)for ptosis and ophthalmoplegia after 4 week-treatment were 86.3% and 75%, respectively, while they were 50% and 30% in patients with traditional oral administration. There was statistically significant difference only in MMS (rather than symptom relief rate and generalization conversion rate)between two groups. Noserious complications (except for intraorbital hematoma) were found in OMG patients during the treatment period.
CONCLUSION
Repeated peribulbar injection of triamcinolone acetonide can effectively alleviate the initial symptoms of OMG patients. However, the evaluation of its long-term efficacy is still needed.
This study has been clinically registered by Chinese Clinical Trial Registry (ChiCTR), first trial registration date:05/07/2019, registration number: ChiCTR1900024285.
Eosinophilic Meningitis After Bovine Graft Duraplasty:a Case Report and Literature Review
Authors: Xu Yuxin , Zha Jian , Che Yuanyuna , Yi Zhaoshi , Wang Ruiyan , Yu Xiongying , Zhong Jianmin , Chen Yong
Published: June 2023

Background
Eosinophilic meningitis after bovine graft duraplastyis is extremely rare, and cerebrospinal fluid cytology is of great significance for the diagnosis of this disease.Conventional anti-infective treatment was ineffective in most patients, and symptoms were relieved after the use of steroids or removal of the artificial dura.
Case presentation:
We report the first case of eosinophilic meningitis after bovine graft duraplastyis in China.A 7-year-old girl underwent cerebellar tumor resection and duraplasty in our hospital, using bovine dura mater.After 13 days, she developed fever, poor mental state, and cervical resistance. The cerebrospinal fluid(CSF) examination showed increased white blood cells, low glucose, and high protein. The Cerebrospinal fluid cytology revealed an eosinophil-reactive type. Metagenomic next-generation sequencing of cerebrospinal fluid was negative and no tumor cells were found in CSF. Vancomycin and meropenem were ineffective in treatment, but symptoms disappeared after dexamethasone administration.Cerebrospinal fluid improved after immunotherapy.Symptoms did not recur after discontinuation of antibiotics.
Conclusion
Eosinophilic meningitis after bovine graft duraplastyis is extremely rare, and cerebrospinal fluid cytology is of great significance for the diagnosis of this disease.Conventional anti-infective treatment was ineffective in most patients, and symptoms were relieved after the use of steroids or removal of the artificial dura
Trace elements and arsenic speciation in Paracentrotus lividus from North-West Mediterranean Sea
Authors: LEUFROY Axelle , Bouchoucha Marc , Rivière Gilles , Guérin Thierry , Jitaru Petru
Published: June 2023

Levels of 14 trace elements (Al, Ti, V, Cr, Mn, Co, Ni, Zn, As, Se, Cd, Sn, Hg and Pb) and 5 arsenic species (arsenite/As(III), arsenate/As(V), monomethylarsonic acid/MA, dimethylarsinic acid/DMA and arsenobetaine/AsB) were assessed in the gonads of sea urchin samples (Paracentrotus lividus) from North-West Mediterranean Sea (French coast). The samples were collected from 13 sites characterized by different types and levels of chemical contamination. Trace elements levels were measured by inductively coupled plasma-mass spectrometry (ICP-MS) following microwave (acid) digestion in a closed system, whereas As speciation analysis was carried out by ion-exchange liquid chromatography coupled with ICP-MS after microwave assisted extraction. High levels of trace elements were found in sea urchins sampled from Corsica whereas the samples from Théoule were found to be the least contaminated. From all the analyzed urchin samples, none showed Cd, Hg or Pb concentrations above the regulatory levels set by the European Community (EC) No. 1881/2006 for seafood or bivalve mollusks. Regardin arsenic specation, AsB was confirmed to be the predominant species. Inorganic As (As(III) + As(V)) was mainly constituted by As(III), which was quantified in all samples. Methylated As forms (MA and DMA) represent 9 to 23% of the total As.
Correcting for the nonuniform boron distribution in a tumor for BNCT dose calculation
Authors: Teng Yi-Chiao , Chen Jiang , Zhong Wan-Bing , Liu Yuan-Hao
Published: June 2023

Most BNCT treatment planning systems perform dose calculations based on the assumption of a homogeneous BPA distribution in tumors, which leads to dose distortion due to the difference between the TNR range measured in PET images and the target delineation in CT images of the treatment plan. The heterogeneous BPA distribution in the target of the treatment plan can be obtained by image fusion. This study provides a way to quantify a heterogeneous BPA distribution based on PET images. Theoretically, the same mean TNR for dose calculation by homogeneous or heterogeneous BPA distribution should get almost the same mean dose. However, slightly different mean doses are found due to the partial volume effect for a small target volume. The wider the BPA distribution is, the higher the impact on the DVH distribution is. Dose distribution with homogeneous boron distribution may be overestimated in low boron uptake regions by wrong boron concentration and neutron flux depression. To accurately give the tumor prescription dose and achieve better tumor control, for low dose regions of the tumor should be considered more BNCT treatments or combined with other treatment modalities. The heterogeneous boron distribution must be taken into consideration to have an accurate dose estimation. Therefore, the way how medical physicists and clinicians process the TNR in GTV should be refined, and the method demonstrated in the work provides a good reference.
Beneficial effects of Angiotensin II Receptor Blockers on Mortality in Patients with COVID-19: a Retrospective Study from 2019 to 2020 in China
Authors: Xu Ke , He Wu , Yu Bo , Zhong Kaineng , Zhou Da , Wang Dao Wen
Published: June 2023

Background
COVID-19 pandemic has become a serious global public health problem. Although the use of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II receptor type 1 blockers (ARBs) has been recommended in patients with COVID-19 and cardiovascular diseases (CVDs), according to the results of some small-sample retrospective analyses; however, there is still a lack of sufficient evidence to validate their efficacy. This multicenter retrospective study investigated whether ACEI/ARB administration was beneficial in patients with COVID-19 and CVDs.
Methods
A total of 11,231 patients with confirmed COVID-19 and CVDs, from 138 hospitals in Hubei Province, were included in this multicenter retrospective study. We compared the clinical characteristics and outcomes between the ARB and non-ARB groups and analyzed the risk factors for in-hospital death using univariate and multivariate Cox regression analyses and Kaplan–Meier curves.
Results
In the multivariate Cox regression model, after adjusting for age, gender, comorbidities, and in-hospital medications, ARB use was associated with lower all-cause mortality (adjusted HR, 0.53; 95% CI, 0.38–0.73; P < 0.001). After propensity score-matched analysis, the adjusted HR for the use of ARB associated with all-cause mortality was 0.62 (95% CI, 0.40–0.88; P = 0.02). Further subgroup analyses found that the adjusted HRs for the use of ARB associated with all-cause mortality were 0.52 (95% CI, 0.30–0.89; P = 0.016), 0.37 (95% CI, 0.21–0.64; P < 0.001), 0.42 (95% CI, 0.28–0.64; P < 0.001), and 0.55 (95% CI, 0.37–0.84; P = 0.005) in patients with heart failure, diabetes, and hypercholesterolemia, and severe COVID-19, respectively.
Conclusions
ARB administration was significantly associated with a lower risk of all-cause mortality in patients with COVID-19 and CVDs.
Trial registration
ClinicalTrials.gov NCT05615792.