bluuebunny/crossref_metadata_2025 huggingface dataset:
Aneurysmal Subarachnoid Hemorrhage After Cesarean Section Under Spinal Anesthesia: A Case Report
Authors: Eddin Adnan Saad , Shaikh Nissar
Published: October 2022

Background

The incidence of cerebral aneurysms in the pregnant population is similar to that of the non-pregnant population. Subarachnoid hemorrhage occurs in 5.8 per 100,000 deliveries among women between 15- and 44-year-old. Studies have found that the incidence of aneurysmal rupture is higher during the third trimester and lower during the first trimester. The risk of aneurysmal rupture and subarachnoid hemorrhage during general anesthesia or spinal anesthesia is unclear. We report a case of aneurysm rupture in the postpartum period.

Case

We describe a case of a 28-year-old woman, Gravida 3 Para 2, who went elective Cesarean delivery under spinal anesthesia at 39 weeks. She developed a headache, right-sided body weakness, and left-sided focal seizures postoperatively. Computed Tomography (CT) scan showed basal ganglia hemorrhage with intraventricular extension, subarachnoid hemorrhage, and midline shift to the right side. The World Federation of Neurological Surgeons (WFNS) grade was 4, and the modified Fischer grade was 4. A right frontal external ventricular drain was inserted, and the patient was admitted to the intensive care unit (ICU). Magnetic Resonance Angiography (MRA) and Magnetic Resonance Venography (MRV) showed a small left supraclinoid aneurysm, and the patient underwent balloon-assisted coiling. Seven days later, the Glasgow Coma Scale (GCS) dropped again, the Computed Tomography (CT) scan showed brain edema, and decompressive craniectomy was done. The patient subsequently improved, and later the external ventricular drain (EVD) was removed, and the patient was referred to a rehabilitation center. Cranioplasty was done three months later. Glasgow Outcome Scale (GOS-E) after six months was 6 (moderate disability).

Conclusion

The use of vasopressors and cerebrospinal fluid (CSF) leakage may increase the risk of cerebral aneurysm rupture after spinal anesthesia.
Predicting Rare Earth Elements Concentration in Coal Ashes with Multi-Task Neural Networks
Authors: Song Yu , Zhao Yifan , Ginella Alex , Gallagher Benjamin , Sant Gaurav , Bauchy Mathieu
Published: October 2022

The increasing demand for rare earth elements (REEs) makes them a scarce strategic resource for technical developments. In that regard, harvesting REEs from coal ashes—a waste byproduct from coal power plants—offers an alternative solution to conventional ore-based extraction. However, this approach is bottlenecked by our ability to screen coal ashes bearing large concentrations of REEs from feedstocks—since measuring the REE content in ashes is a time-consuming and costly task requiring advanced analytical tools. Here, we propose a machine learning approach to predict the REE contents based on the bulk composition of coal ashes (which is easily measurable under the current testing protocol). We introduce a multi-task neural network that simultaneously predicts the contents of different REEs and, importantly, exhibits notably improved accuracy than the single-task models. Further model analyses reveal key data patterns for screening coal ashes with high REE concentrations. Teaser: With machine learning, high-throughput screening of REE-bearing coal ashes can be fulfilled based on a simple measurement.
Development and Parameter Estimation of a Low Order Model for a Hyperelastic Cantilever Plate Exhibiting 2:1 Resonant Response
Authors: Jaber Nizar , Bilal Nasir , Bajaj A K
Published: October 2022

This work presents the results of an experimental investigation and a low-order model development for complex resonant dynamics of a cantilever macro-plate. The plate is fabricated from a material using 3D additive manufacturing technology and the material is assumed to be ‘hyperelastic’. The geometry of the plate with cut-outs is analytically optimized assuming a linear elastic material such that the second bending mode frequency 𝜔02 is approximately twice the first twisting mode frequency 𝜔11. Based on the observed ‘near’ 2:1 resonant response under harmonic excitation near 𝜔02, a low-order 2 DOF nonlinear dynamic model is developed to simulate the plate response. A unique and novel stepwise iterative approach is developed for the modal parameter extraction. The unknown modal parameters are extracted using Harmonic Balance solutions, constructing frequency response curves, and curve-fitting techniques. The results are then validated using long-time integration for the developed model. A good agreement is observed between the analytical and experimental results for the different excitation levels considered.
Prediction of stable radon fluoride molecules and geometry optimization using first-principle calculations
Authors: Kang Jaeeun , Park Ina , Shim Ji Hoon , Kim Duck Young , Um Wooyong
Published: October 2022

Noble gases possess extremely low reactivity because their valence shells are closed. However, previous studies have suggested that these gases can form molecules when they combine with other elements with high electron affinity, such as fluorine. Radon is a naturally occurring radioactive noble gas, and the formation of radon-fluorine molecules is of significant interest owing to its potential application in future technologies that address environmental radioactivity. Nevertheless, because all isotopes of radon are radioactive and the longest radon half-life is only 3.82 days, experiments on radon chemistry have been limited. Here, we study the formation of radon molecules using first-principles calculations; additionally, possible compositions of radon fluorides are predicted using a crystal structure prediction approach. Similar to xenon fluorides, di-, tetra-, and hexa-fluorides are found to be stabilized. Coupled-cluster calculations reveal that RnF6 stabilizes with Oh point symmetry, unlike XeF6 with C3V symmetry. Furthermore, relativistic effects are considered to calculate physical properties, such as bond length, bond angle, and vibrational spectra, and the results suggest that relativistic effects should be considered to describe properly many-electrons of Rn. The molecular stability of radon fluoride obtained through calculations may lead to advances in radon chemistry research.
Characterisation of Clostridioides difficile spore response to sodium hypochlorite using EM-imaging and Raman Spectroscopy
Authors: Malyshev Dmitry , jones Imogen , McKracken Matthew , Harper Glenn , Lovleen Tina Joshi , Andersson Magnus
Published: October 2022

Background Clostridioides difficile is a spore forming bacterial species that is the major causative agent of serious infection in hospitals. C. difficile spores are highly resilient to disinfection methods and to prevent infection, common cleaning protocols use sodium hypochlorite solutions to decontaminate hospital surfaces and equipment. However, there is a balance between minimising the use of harmful chemicals to the environment and patients as well as the need to eliminate spores, which can have varying resistance properties between strains. In this work, we compare the effect of sodium hypochlorite on different C. difficile clinical isolates and the chemical's impact on spores' biochemical composition. Biochemical changes can, in turn, change spores' vibrational spectroscopic fingerprints, which can impact the possibility of detecting spores in a hospital using Raman based methods.
Results First, we found that the isolates show different susceptibility to hypochlorite, with the R20291 strain, in particular, showing less than 1 log reduction in viability for a 0.5 % hypochlorite treatment, far below typically reported values for C. difficile. Second, TEM and Raman spectra analysis of hypochlorite-treated spores revealed that some hypochlorite-exposed spores remained intact and not distinguishable to controls. Finally, we saw differences in the ultra-structure of C. difficile and B. thuringiensis spores in response to hypochlorite.
Conclusion This study highlights the ability of certain C. difficile spores to survive practical disinfection exposure as well as the changes in spore spectra that can be seen using Raman spectroscopy. These findings are important to consider to avoid a false-positive response when screening decontaminated areas.
An Efficient High-Order Two-Level Explicit/Implicit Numerical Scheme For Two-Dimensional Time Fractional Mobile/Immobile Advection-Dispersion Model
Authors: Ngondiep Eric
Published: October 2022

This paper constructs a new two-level explicit/implicit numerical scheme in an approximate solution for the two-dimensional time fractional mobile/immobile advection-dispersion problem. The stability and error estimates of the proposed technique are deeply analyzed in the $L^{\infty}(0,T;L^{2})$-norm. The developed approach is less time consuming, fourth-order in space and temporal accurate of order $O(k^{2-\frac{\lambda}{2}})$, where $k$ is the time step and $\lambda$ denotes a positive parameter less than $1$. This result shows that the two-level explicit/implicit formulation is fast and more efficient than a large class of numerical schemes widely discussed in the literature for the considered problem. Numerical experiments are performed to verify the theoretical studies and to demonstrate the efficiency of the new numerical method.
Oligogenic prediction of eye and hair colour in the Danish population
Authors: Cabrejas Amaia , Athanasiadis Georgios
Published: October 2022

Genetic predictions of external traits are commonplace in current research, but little is known about the performance of such predictions in Nordic populations. Here, we perform eye and hair colour prediction in a sample of 723 Danish high school students using the oligogenic HIrisPlex method. We analysed the genetic structure of the Danish population by use of principal component analysis. Hair and eye colour predictions were carried out with an R script that was based on the HIrisPlex method. We predicted brown, blue and green colour with an accuracy of 92.17%, 98.38% and 0.73%, respectively. We also obtained accuracies of 80.95% for black, 93.72% for blond, 6.16% for brown and 53.33% for red hair colour. Our predictions were overall less accurate than previously reported in the HirisPlex study. The dissimilarities might be explained by differences in genetic ancestry between training and target samples. Due to the complexity eye and hair colour present as traits, a polygenic risk model is more suitable for their prediction.
Sirt1 overexpression inhibits fibrous scar formation and improves outcome after cerebral ischemic injury by deacetylation of 14-3-3ζ
Authors: Chen Yue , Huang Jiagui , Liu Jie , Zhu Huimin , Li Xuemei , Wen Jun , Tian Mingfen , Ren Jiangxia , Zhou Li , Yang Qin
Published: October 2022

Fibrous scar is one of major factors for hindering synaptic regeneration after central neural system (CNS) injury. Silencing information regulator 2 related enzyme 1 (Sirt1) can regulate lung, liver, kidney and heart fibrosis. However, it is unclear how the fibrous scar forms and is regulated and it is unknown whether and how Sirt1 regulates formation of the fibrous scar after cerebral ischemic stroke. The present study tests whether and how Sirt1 affects formation of the fibrous scar following cerebral ischemic injury. Therefore, we examined the expression and localization and the effects of Sirt1 on the formation of the fibrotic scar after middle cerebral artery occlusion/reperfusion (MCAO/R) injury in vivoand transforming growth factor β1 (TGF-β1)-induced meningeal fibroblasts migration, proliferation, transdifferentiation and extracellular matrix (ECM) secretion. Finally, we explored the molecular mechanisms underlying the Sirt1-regulated fibrosis process in vitro. We found that MCAO/R injury induced fibrotic scar formation in the ischemic area accompanied with downregulation of Sirt1 expression. Overexpression of Sirt1 reduced the infarct volume in acute stage, alleviated loss of Nissl body and formation of fibrotic scar in middle and later periods, further promoted the synaptic plasticity and neurological function recovery. Similarly, Sirt1 expression is also downregulated during TGF-β1-induced fibrosis model. Sirt1 overexpression inhibited fibroblasts migration, proliferation, transdifferentiation into myofibroblasts and secretion of ECM by controlling deacetylation of lysine at K49 and K120 sites of 14-3-3ζ in vitro. Therefore, we believe Sirt1 can regulate fibrous scar formation and improve outcome after cerebral ischemic stroke through controlling deacetylation of 14-3-3ζ.
Study on Mechanical Properties and Energy Change of Rock Materials in Whole Splitting Process Based on peridynamics
Authors: Li Hewan , Liu Jian , Wang Laigui , Ren Tianjiao
Published: October 2022

Aiming at the problem that the evolution process of rock internal deformation and fracture cannot be observed directly, this paper proposes that based on the bond-base peridynamic theory in peridynamics and the PMB model of brittle materials, combined with laboratory experiments, rock samples with different inclination angles are analyzed from the angle of energy. The method of analyzing the whole process of shearing, and the lammps software is used to simulate the internal energy change of rock-like materials under shear conditions, and the damage evolution law of samples with different dip angles is studied from macro and micro perspectives.The result shows that prefabricated cracks and the inclination of cracks are important factors for specimen damage, which has important theoretical value for rock mechanics research. The research results can reduce the occurrence of rock burst accidents or reduce the difficulty of mine support, reduce the cost of mining engineering, and improve the mine safety level.
Effects of a mixture of Iranian native probiotics on kidney oxidative injuries induced by cadmium chloride: A biochemical, anti-inflammatory, Antioxidative and antiapoptosis approach
Authors: salar shakiba , keshtmand zahra
Published: October 2022

Introduction: Cadmium(Cd)tends to produce severe oxidative stress triggering serious clinical problems and tissues damage.The purpose of the current investigation was to study the efficacy of native Iranian probioticsin protection against Cd-induced kidney damages at histopathological and biochemical levels.
Material and Methods: Twenty-one adult male Wistar rats were randomized into three groups of seven rats(control,receivingCd(3mg/kg) and Cd+mix probiotics(Cd+Pro) for 30 days).Histological changes were assessed using H&E,Trichrome Masson, and PAS staining, and qRT-PCR was used for evaluating apoptotic,and pro-inflammatory genes expression levels. Serum biochemical parameters and tissue antioxidant status were also evaluated.
Result:The histopathological results revealed that the probiotic strains recovered the tissue damage caused by Cd in kidneys.The results of qRT-PCR showed the up-regulation of Bax,p53,caspase3 and down-regulation of Bcl2,TNF-α,and IL-6 gene expressions in the kidneys of Cd+mix Pro treated rats compared with Cd-treated animals.Also,Cd+Pro treated rats displayed a reduction in MDA,high levels of SOD,catalase activities,reduced serum contents of Na+,Creatinine, urea, finally higher levels of K+and total protein compared toCd-treated animals.
Conclusion: Iranian native probiotics exhibited antioxidant, anti-inflammatory, and anti-apoptotic functions it is suggested to use them in pharmaceutical studies to further investigate their health benefits.
Inverse scattering transform and dynamics of soliton solutions for nonlocal focusing modified Korteweg-de Vries equation
Authors: Zhang Xiao-Fan , Tian Shou-Fu , Yang Jin-Jie , Zhang Tian-Tian
Published: October 2022

The Riemann-Hilbert (RH) problem is developed to study the general N-soliton solutions of the nonlocal modified Korteweg-de Vries (mKdV) equation in this work. For the initial value belonging to Schwarz space, we firstly obtain the corresponding eigenfunctions and scattering data in the direct scattering process. Then the suitable RH problem of the nonlocal mKdV equation is successfully established. The exact expression of the solution for the equation is derived via solving the RH problem. Utilizing the symmetry of scattering data, the abundant phenomena corresponding to different eigenvalues are analyzed, including bounded solutions, singular solutions, degenerate solution and kink solutions. Finally, the propagation behaviors of the solution (including one-, two-, and three soliton) are observed, and the characteristic lines are further used to analyze the continuity and other phenomena of the solution.
Mathematics Subject Classification (2010) 35Q15 · 35Q51 · 45Q05
A tuft cell - ILC2 signaling circuit provides therapeutic targets to inhibit gastric metaplasia and tumor development
Authors: O'Keefe Ryan , Carli Annalisa , Baloyan David , Chisanga David , Shi Wei , Afshar-Sterle Shoukat , Eissmann Moritz , Poh Ashleigh , Pal Bhupinder , Seillet Cyril , Locksley Richard , Ernst Matthias , Buchert Michael
Published: October 2022

Although gastric cancer is a leading cause of cancer-related deaths, systemic treatment strategies remain scarce. Here, we report the pro-tumorigenic properties of the crosstalk between intestinal tuft cells and type 2 innate lymphoid cells (ILC2) that is evolutionarily optimized for epithelial remodeling in response to helminth infection. We demonstrate that tuft cell-derived interleukin 25 (IL25) drives ILC2 activation, inducing the release of IL13 and promoting epithelial tuft cell hyperplasia. While the resulting tuft cell - ILC2 feed-forward circuit promotes gastric metaplasia and tumor formation, genetic depletion of tuft cells or ILC2s, or therapeutic targeting of IL13 or IL25 alleviates these pathologies in mice. In gastric cancer patients, tuft cell and ILC2 gene signatures predict worsening survival in intestinal-type gastric cancer where ~40% of the corresponding cancers show enriched co-existence of tuft cells and ILC2s. Our findings suggest novel roles for ILC2 and tuft cells, along with their associated cytokine IL13 and IL25 as gatekeepers and enablers of metaplastic transformation and gastric tumorigenesis, thereby providing novel therapeutic vulnerabilities of for the treatment of these pathologies.
Evaluation of Soil CO 2 Efflux and its Influence Factors in a Revegetated Area in Tengger Desert, NW China
Authors: Nan Yicong , Huang Lei , Yang Yonggang , Yang Guisen , Wang Zeqing
Published: October 2022

Soil profile CO2 transport and production are vital in the carbon stock in desert artificial vegetation ecosystem. In this study, the soil profile CO2 concentration, soil water content and temperature at depths of 0–40 cm were measured at four revegetated sites (1956, 1964, 1981 and 1987), located in the southeastern edge of Tengger desert, China. The gradient method was applied to simulated soil gas diffusion coefficient and soil profile CO2 efflux. We found that the soil profile CO2 concentration increased with depths, while the soil CO2 diffusion coefficient, soil CO2 efflux and production in upper layers were significantly higher than those in bottom layers. The CO2 diffusion coefficient decreased at first and then increased with revegetation age. The soil profile CO2 concentration, CO2 efflux and production increased with revegetation age. The simulated soil surface CO2 efflux were 0.54 µmol·m− 2·s− 1, 0.49 µmol·m− 2·s− 1, 0.44 µmol·m− 2·s− 1 and 0.25 µmol·m− 2·s− 1 at 1956, 1964, 1981 and 1987 revegetated sites, respectively. The soil surface CO2 efflux mainly came from the layers of 0–10 cm, which contributed to 76.4% − 94.9% of the total. The structural equation modeling (SEM) explained 97.0% of the variations in soil surface CO2 efflux (F0). The effects of soil CO2 concentration, temperature and water content in the layers of 10 cm, and plant properties on soil surface CO2 efflux were 0.977, 0.516, -0.358 and − 0.156, respectively, and the interaction between soil temperature and water content was 0.439, which meant that the soil temperature and water content significantly influenced soil CO2 efflux.
Study on magnetic pulse crimping process for joining large diameter aluminum alloy tube/magnesium alloy shaft
Authors: Chen Chang , Han Zichuan , Cui Junjia , Li Guangyao , Jiang Hao
Published: October 2022

A structure for joining 6061T6 aluminum alloy tube and AZ31B magnesium alloy shaft via the magnetic pulse crimping process was proposed. The forming process, mechanical properties, failure modes, corrosion behaviors of the joint were studied. The results showed that the enormous Lorentz force drove the wall of aluminum alloy tube to move towards the groove of magnesium alloy shaft at high-velocity, thus realized mechanical locking and formed joint. Through torsion tests, it was found that the mechanical properties of the joint with different process parameters varied. There were two failure modes for joint: torsional separation and torsional crack. Specifically, discharge time, groove angle and discharge energy for torsional crack was respectively 1, 90°, 28 kJ and 3, 90°, 25kJ. The maximum torque was up to 961.99N·m under discharged twice, 90° groove angle and 25kJ discharge energy. Through neutral salt spray corrosion tests, it was found that the maximum torque only decreased by 28.03% after corrosion for 192h. It indicated that the corrosion resistance of joint was good relatively.
The angular gyrus serves as an interface between the non-lexical reading network and the semantic system - evidence from dynamic causal modeling
Authors: Junker Frederick Benjamin , Schlaffke Lara , Lange Joachim , Schmidt-Wilcke Tobias
Published: October 2022

Understanding encoded language, such as written words, requires multiple cognitive processes that act in a parallel and interactive fashion. These processes and their interactions, however, are not fully understood. Various conceptual and methodical approaches including computational modeling and neuroimaging have been applied to better understand the neural underpinnings of these complex processes in the human brain. In this study, we tested different predictions of cortical interactions that derived from computational models for reading using dynamic causal modeling. Morse code was used as a model for non-lexical decoding followed by a lexical-decision during an MR examination. Our results suggest that individual letters are first converted into phonemes within the left parietal lobe, followed by a phoneme assembly to reconstruct word phonology, involving the left inferior frontal cortex. To allow the identification and comprehension of known words, the inferior frontal cortex then interacts with the semantic system via the left angular gyrus. As such, the left angular gyrus is likely to host phonological and semantic representations and serves as a bidirectional interface between the networks involved in language perception and word comprehension.
Are aluminum and iron resorbed from old leaves?
Authors: Hu Nan , Mao Qinggong , Sun Xibin , Xu Qianhao , Li Meimei , Chen Hao
Published: October 2022

Purpose
Leaf resorption is an important mechanism for plant nutrient conservation, but not all elements are resorbed by plants. It is generally believed that aluminum (Al) and iron (Fe) are not resorbed from old leaves due to their toxic effects. However, the fact is that positive Al and Fe resorptions have been found in some specific cases. To date, no one has addressed these specific cases and the mechanisms underlying.
Methods
Here, a data synthesis was conducted to explore the patterns and controls on leaf resorption efficiency of Al and Fe, based on 34 published studies with 272 data points. We aimed to answer whether and why Al and Fe can be resorbed from old leaves.
Results
The resorption efficiency of Al was positive in conifer plants (11.3%), but was negative in deciduous and evergreen plants (-94.2% and − 111.2%, respectively). The resorption efficiency of Fe was positive in nitrogen-fixing plants (39.2%), but was negative in non-nitrogen-fixing plants (-37.0%). Lower soil pH favored leaf Al resorption, but limited leaf Fe resorption. Higher precipitation inhibited leaf Fe resorption.
Conclusions
In contrast to the general belief, our study highlights that Al and Fe can be resorbed from old leaves, depending mainly on plant functional group and soil environment. This knowledge is an important supplement for understanding leaf resorption process, and helpful for modeling global biogeochemical cycles.
Hadamard bent sequences-survey and new results
Authors: Shi Minjia , Xiao Xianglin , Sole Patrick
Published: October 2022

A new notion of bent sequence related to Hadamard matrices was introduced recently, motivated by a security application (Solé et al, 2021). The subclass of self-dual bent sequences was studied from the standpoint of generation and symmetry (Shi et al., 2022). An analogous study was led for complex Hadamard matrices (Shi et al., submitted). We survey these recent results, and add some new results (asymptotics, Mutually Unbiased Hadamard matrices).
MSC (2020): 05B20, 94D10, 94B25
Development and validation of a diagnostic prediction model reminiscent of systemic inflammation and organ interaction in heart failure preserved ejection fraction (HFpEF) patients
Authors: Zhou Rong , Xia Yi-Yuan , Li Zheng , Wu Li-Da , Shi Yi , Ling Zhi-Yu , Zhang Jun-Xia
Published: October 2022

Purpose
Systemic inflammation and reciprocal organ interactions are associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF). Herein, we proposed a simple diagnostic model with markers from complete routine blood test as well as liver and renal dysfunction for HFpEF.
Patients and methods:
This is a hospital-based single-center, cross-sectional observation study. 1808 eligible patients with documented cardiovascular diseases were enrolled. HFpEF was diagnosed independently by two expert cardiologists according to the clinical manifestation, echocardiography and the N-Terminal pro B-type natriuretic peptide. A diagnostic model for HFpEF was developed by logistic regression and assessed by ROC and Brier score. Then, the model was validated by the 10-fold cross-validation and presented as nomogram and a web-based online risk calculator as well.
Results
Patients with HFpEF account for 47.23% in development data. Univariate, multivariate and LASSO regression analysis revealed that age, Hb, NLR, AST/ALT ratio, Cr, UA, atrial fibrillation, and pulmonary arterial hypertension were associated with HFpEF. The predictive model exhibited reasonably accurate discrimination (ROC, 0.753, 95% CI, 0.732 to 0.772) and calibration (Brier score was 0.200). Subsequent internal validation showed good discrimination and calibration (AUC = 0.750, Brier score was 0.202).
Conclusion
Our new diagnostic model incorporating markers of inflammation, liver-heart and kidney-heart interactions has the predictive ability for HFpEF, and may be helpful for timely diagnosis of patients with HFpEF.
WITHDRAWN: Investigation of regenerative effects of Theranekron ® and Misoprostol after partial hepatectomy in rats
Authors: YILMAZ İsmet , KANAT Burhan Hakan , YILDIZ Azibe , BİLGİÇ Yılmaz , BERK Ahmet , UYUMLU Ayşe Burçin , Burak Muhammet
Published: October 2022

Background/Aims:
In the present study we were aimed to investigate/compare regenerative effects of Theranekron® (TC) and Misoprostol (MS) after Partial Hepatectomy (PH) in rats.
Material and Methods:
This study was conducted in 38 rats, they were divided in to 5 groups and 14 days study periot.
Results, and Conclusions:
When considering biochemical and histopathological results; we were seen that before and after PH 7 days duration and used dozes of both drugs was not sufficient and also higher dozes and at least 10 days periot may be necessary. Althought some literatures were reported about positive effects of TC and MS on epithelial growing, we have not seen that they have not any positive effect on liver regeneration. For future research -at higher dozes and durations- may be found effective.
Antioxidant vitamin attenuated the carcinogenesis effect of HPV16E7 by inactivating PI3K/AKT/TERT axis
Authors: Wang Hongyan , Wang Hao , Wen Jinglin , Wang Meihan , Guo Liyuan
Published: October 2022

Objectives: The aim of this study is to explore the effect of β-carotenoids on the HPV related cervical cancer.
Methods: Western blot was used to detect the protein expression. CCK8 and transwell assays were used to determine proliferation and metastasis ability of cancer cell.
Results: In this study, we found HPV16E7 promoted the development of cervical cancer by elevating the expression of TERT. TERT was upregulated in tumor tissue and positively associated with the progression of cervical cancer. The patient with higher expression of TERT predicted to have poorer prognosis. HPV16E7 enhanced the expression of TERT by activating PI3K/AKT signaling pathway.
Conclusions: Antioxidant vitamin β-carotenoids could inhibit the effect of HPV16E7 on the expression of TERT by inactivating the PI3K/AKT signaling pathway and suppressed the cervical cancer progression induced by HPV16E7.
Brief Ornithology of Blue-throated Barbet (Psilopogon asiaticus)
Authors: SAHA SANJIT , SAHA RINKI
Published: October 2022

Last year in India lockdown started on 23rd March, 2020 due to pandemic situation of COVID-19 for the outbreak of SARS-CoV-2 at first for 18 days and then extended for phase by phase with the imposition of strong restrictions for movement. During that time lockdown was already there in several countries of the World. So, all the people of Global village faced the situation like house arrest. All the social, official, commercial and institutional activities were prohibited for the people. Apart from the household work most of the people got themselves busy in the unproductive work like watching TV and using mobile phone. For morning and evening work we were compelled to use only the lawn and backyard premises of the household. During our walk we have interacted with 35 species of birds. We became fond of Blue-throated Barbets (Psilopogon asiaticus) during our walk and documented the roosting, nesting, foraging behaviour of the Blue-throated Barbets. We have found great camouflage adaptation of Blue-throated Barbets and several times only bird call/song helped us to sight the bird. We have recorded bird calls/songs and all the data related to sighting and audio were submitted to ebird platform. Spectrograms of audios were analyzed to decipher the bird call/song. Lockdown helped us to explore fundamental lessons of ornithology.
Mass-Energy Equivalence in Bound Three-Nucleon Systems
Authors: Filikhin Igor , Suslov Vladimir , Vlahovic Branislav
Published: October 2022

The mass defect formula reflects the equivalence of mass and energy for bound nuclear systems. We consider the three-nucleon systems 3H and 3He assuming the neutron and proton to be indistinguishable particles (AAA model) or taking into account realistic masses for neutrons and protons (AAB model). We discuss the disagreement between the AAA model and the mass defect formula, which is related naturally to the AAB model. Also, we demonstrate that ignoring the neutron-proton mass difference leads to the uncertainty for AAA calculations of several keV that overlap the realistic calculations accuracy estimated before in the literature. To show another manifestation of the mass-energy equivalence, we perform AAA realistic calculations varying nucleon mass and scaling the depth of pair potential to show the mass-energy compensation effect. Comparing the results of different authors, we show that the contribution of attractive three-body potential to the Hamiltonian can be compensated by increasing the nucleon mass. For the binding energy calculations, we apply the differential Faddeev equations.
A Novel Fusion Technique for GeoEye-1 Satellite Imagery
Authors: Elshora Mohamed
Published: October 2022

Color distortion is the main weakness of the current fusion techniques, which occurs because of radiometric differences between panchromatic (PAN) and multispectral (MS) images. In this study, a novel fusion technique was developed to merge the PAN and MS images of the GeoEye-1 satellite and produce superior fused images without color distortion. This technique proposes reducing the difference in radiometry between the PAN band and the MS bands by using only the parts of the MS bands inside the area of the PAN band. Therefore, modification coefficients were used for the MS bands in the definition of the intensity (I) equation based on their overlapping areas with the PAN band. As the reflectance of vegetation is high in the NIR band and low in the RGB bands, this technique suggests using an additional coefficient for the NIR band in the definition of the I equation to add the correct effect of vegetation. This coefficient is variable for all types of land cover based on the percentage of the agricultural areas within the image, which leads to significant and stable performance for all types of land cover. This study aims to evaluate the performance of this technique by a comparison with five standard fusion techniques: fast-intensity-hue-saturation, principal component analysis, Gram Schmidt fusion, hyper-spherical color space, and Ehlers fusion. Three datasets of GeoEye-1 satellite PAN and MS images in Tanta City, Egypt, with different land cover classes (agricultural, urban, and mixed areas), were used in this study. The output fused images were compared with the original PAN and MS images by statistical analysis and visual inspection. The proposed fusion technique demonstrated great efficiency in producing fused images of superior spatial and spectral quality for all types of land cover.
Leniency Policies and Cartel Success: An Experiment
Authors: Kim Jeong Yeol , Noussair Charles
Published: October 2022

Cartels are often fought by granting leniency, in the form of forgiveness of penalties, to whistle-blowers. This study employs a laboratory experiment to compare leniency programs that differ with respect to fine size and whether a second whistle-blower may apply for leniency. The results show that leniency does not affect the probability that a cartel forms, but is effective in exposing cartels and thereby inhibiting cartel success. Higher fines are more effective, but allowing leniency to a second whistle-blower is no more effective than granting leniency to only one whistle-blower.
Regulating Antimicrobial usage in Livestock Farming: Innovative and interdisciplinary solutions
Authors: NATHAN MUGENYI , PRIZE NINSIIMA , Byakika-Kibwika Pauline , Clarke Rose Nanyonga
Published: October 2022

Antimicrobials have been used extensively in Livestock production. The overuse and misuse of antimicrobials has resulted in the development of drug resistant pathogens that is Antimicrobial Resistance (AMR). The emergence and spread of drug resistant pathogens has resulted into AMR and has continued to threaten our veterinary and health care systems. The most alarming situations include the rapid global spread of multi-and pan-resistant bacteria which have been referred to as “superbugs”. These have caused infections that are un-treatable with the available medicines in our health care and veterinary settings.AMR is one of the top ten global health and development threats facing humans and animals according to the World Health Organization hence the need for urgent multisectoral action. Antimicrobials are medicines used for prophylaxis, treatment and prevention of infections in animals, humans and plants. They comprise of antibiotics, antiviral, antifungal and antiparasitics. Antibiotics are increasingly losing their effectiveness as drug-resistance spreads globally resulting into difficulty in treating infections, death of animals and humans. In this paper, we addressed some of the innovative solutions based on an interdisciplinary perspective. We discussed the fundamental concerns for defining policies and strategies to mitigate AMR in Livestock farming, structured a basis for AMR policies and strategies and the key actors in Antimicrobial decision systems.
Titanium (IV) μ-Oxo Complex Supported by Phenoxyimine Ligand: Synthesis, Crystal Structure Characterization, DFT and Molecular Docking Studies
Authors: Sajjan Vinodkumar P. , Gurubasavaraj Prabhuodeyara M , Pujari Vikram , Inamdar Sanjeev , Mukerjee Nobendu
Published: October 2022

A new crystalline complex [Ti{La}] has been synthesized in the reaction of titanium butoxide with a phenoxyimine ligand in a 1:1 stoichiometry in toluene at room temperature under a nitrogen atmosphere. The complex has been characterized by various spectroscopic and analytic techniques. A suitable crystal analysed by X-ray diffraction establishes the formation of a stable binuclear μ-oxo-complex with a hexacoordinate titanium centre. The crystal shows a monoclinic system with space group C 1 2/c 1. X-ray crystal structure analysis reveals that this complex has a rhomboidal Ti-O-Ti core and exhibits a C2 symmetric conformation with distorted octahedral geometry. Density functional theory (DFT) calculations using B3LYP with the basis set of 6-31+G have been performed on the activated species, giving insights into the frontier orbitals and mulliken charge analysis, which showed good correlation with the experimental findings. Additionally, in silico molecular docking of ligand and complex was carried out against HER2 inhibitor kinase. The complex exhibits high binding energy of ΔGb = -19.7 kcal/mol with the active pocket of HER2 (PDB:7JXH) than the ligand ΔGb = -8.5 kcal/mol.
Correlation between red blood cell distribution width (RDW) and disease activity in patients with Rheumatoid arthritis
Authors: kudsi Maysoun , baydoun Bassam , almoallem Moataz
Published: October 2022

Background:
Rheumatoid arthritis is a systemic disease. The active and chronic forms of the disease can cause articular deformities. A lot of clinical and laboratory indicators were used to assess its remission or/and flare. A higher value of red cell distribution width was found in some autoimmune diseases like Rheumatoid arthritis, so it may be used to evaluate the disease activity in these patients.
Objective:
To assess the relationship between elevated RDW and the activity of Rheumatoid arthritis in Rheumatoid arhtritis patients compared with healthy control.
Methods:
A cross-sectional/case-control study was conducted on 84 rheumatoid arthritis patients,diagnosed according to the 2010 American College of Rheumatology/European League Against Rheumatism criteria, attending Damascus Hospital and 84 healthy population, matched in age and gender. Red cell distribution width was compared between the two groups, and between patient groups, according to the presence of anemia.Red cell distribution width value was also compared between the patient group itself, according to the presence of anemia, and the disease activity by using the disease activity 28 score/erythrocyte sedimentation rate. Demographic Data include:age and gender were collected, and data of the disease include: disease durations, disease activity were only collected from the patients. Laboratory tests such as complete blood count reactive protein and erythrocyte sedimentation rate were all measured.
Results:
The age of the patients was 42 ± 8  yr., while it was41.10 ±10  yr., in the control group (P= ).0.274 % were females 85.7% and were males 14.3% in patients group, while, in the control group were female78.58% and were males21.42%.
Higher red cell width value was found in patients when compared with controls, and a positive correlation between it and the activity of the disease was also found in patients.
Discussion
Red blood cell distribution width (RDW) is a test that measures the difference in the volume and size of red blood cells and is routinely used to diagnose anemia.
In our study that included 84 patients and span over a year, we found a statistical relationship between RDW measures and rheumatoid arthritis activity (DAS28-ESR)
Other studies have shown that inflammatory diseases including rheumatoid arthritis affected the hematopoiesis process, as these studies have shown that high levels of inflammatory cytokines such as IL-1, IL-6, and TNF-alpha inhibit the activity of erythropoietin by eliminating the sensitivity of erythroid progenitors towards erythropoietin thus causing immature blood cells to flow into the bloodstream resulting in high RDW.
Chronic inflammation also causes red blood cell life by increasing its degradation thus causing differences in red blood cell sizes.
Conclusions:
In patients with rheumatoid arthritis, the elevation of red cell distribution width may express the disease activity in Rheumatoid arthritis patients.
Effect of renewable energy on the technical efficiency of manufacturing firms in Cameroon
Authors: Koumou Etienne Landry
Published: October 2022

The objective of this paper is to investigate the effect of renewable energy on the technical efficiency of manufacturing firms in Cameroon. The data for the study comes from the Annual Enterprise Surveys (AES) of the National Institute of Statistics (INS) for the period 2012–2019. The method used is the one-step Stochastic Frontier. The results show that the effect of renewable energy on the technical efficiency of manufacturing firms in Cameroon is negative in some cases and positive in others. Renewable energy has a negative effect on the technical efficiency of agro-food and chemical firms. The effect is, on the contrary, positive in the printing and textile sectors, as well as in the wood sector. On the other hand, the technical efficiency of manufacturing firms is around 40.57%. This last result means that manufacturing firms in Cameroon can increase their production by 59.43%, while keeping the same level of production factors.
Population Genetic Structure of Culex quinquefasciatus in Osogbo Metropolis, Nigeria inferred from Mitochondrial COI sequences
Authors: Aremu Harun K. , Adediji Adedapo , Iyoha Alex , Ajayi Ebenezer , Oyafajo Lateefah , Adekale Idris , Musa Dickson , Azeez Luqmon , Adeleke Monsuru
Published: October 2022

Culexmosquito is a major vector of some deadly and debilitating diseases that include lymphatic filariasis and West Nile fever. Understanding the population genetics structure plays a crucial role in unravelling the epidemiological pattern of mosquito-borne disease and facilitating effective vector control measures. Hence, this study investigated the population genetic structure ofCulexmosquitoes within selected urban areas in Osogbo, Osun State, Nigeria using the mitochondrial cytochrome c oxidase subunit I (mtCOI) DNA region. Mosquito samples were collected from twelve (12) sampling sites in different locations in Osogbo, Osun State and identified on the basis of morphological characteristics followed by mtCOIgene amplification and sequencing.Cx. quinquefasciatuswere observed to be significantly distributed in sampling locations. The results of sequence alignment showed stable genetic structure and a shared inter-spatial haplotype owing to the significantly low haplotype diversity (Hd= 0.154; π = 0.112). The TCS network revealed that the dominant haplotype H1 shares a connection with haplotype H19. Tajima’s D values were negative for the sequence datasets with p > 0.05; implying genetic equilibrium of theCOIsequences in all populations. Phylogenetic tree analysis showed sharedCOIsequences and are present in the same subclusters. Intra and interspecies were observed to have varying nucleotide and haplotype diversities. High percentage similarities of theCOIregion may be linked to human activities that have enhanced gene flow and conferred beneficial mutation attributes. Thus, continuation of this trend could be disadvantageous to the vector control mechanisms forCx. quinquefasciatusin the selected population.
Quantitative assessment of resilience engineering in process industries through a novel multi-attribute group decision-making algorithm using interval type-2 fuzzy sets
Authors: Bamdad Shahrooz
Published: October 2022

Nowadays, the promotion of technology has increased the complexity of socio-technical systems, which has led to severe disasters. Human errors and defects in components of a system have previously been recognized as the most important causes of accidents. Still, recent studies have emphasized that the causes of accidents, especially in complex socio-technical systems (CSS), depend on organizational factors, functional changes, and combining a set of unexpected events. With the transition from the traditional static approach to systems, and due to the two features of high interconnectivity and the complexity of modern systems, a new approach called resilience engineering (RE) has been introduced. On the other hand, sophisticated socio-technical systems have a high level of uncertainty that its modeling requires considering tools for dealing with this kind of intricate uncertainty, such as interval type-2 fuzzy sets (IT2FS). In this paper, focusing on process industries, a new algorithm based on multi-criteria group decision-making for evaluating departments of a process industry from RE using the concept of type-2 fuzzy sets is presented. To do this, by introducing the RE criteria in process industries, their weights are calculated as incomplete information received from the decision-makers (DMs). The incompleteness of information is due to the uncertainties in the evaluation of criteria. Then different alternatives are ranked using IT2FS. It is shown that the presented algorithm is relatively consistent with other approaches, and besides simplicity, it has good stability for dealing with different weights for the criteria.
ANKARA ETNOGRAFYA MÜZESİ’NDEKİ İKİ GÜMÜŞ KİTAP KAPAĞI ÜZERİNE GÖRÜŞLER
Authors: YAŞAR Fatma , MİMİROĞLU İlker Mete
Published: October 2022

Altın, gümüş ve bakır levhalar üzerine yapılan süslemelerle zenginleştirilen kitap kapakları ökaristi ayininin vazgeçilmez bir parçası olarak karşımıza çıkar. Erken Hıristiyan toplumların fildişi diptiklerden etkilenerek üretilen kitap kapakları zaman içinde gelişim göstererek farklı tasarımlarla geliştirilmiştir. Değerli taşlarla ve zarif işçilikle süslenen kitap muhafazaları sanatsal bakımından değerlidir. Bu özel kitap kapakları kütüphanelerde kullanılmasından ziyade kiliselerde düzenlenen ayinlerde liturjik bir parçası olarak kullanılmıştır. Farklı dönemlerde yeni tasarımlarla karşımıza çıkan kitap kapakları gerek malzeme gerek üzerinde taşıdığı ikonografi bakımından farklı dönemler içerisinde gelişmiştir. Lakin hiçbir zaman amacının dışında kullanılmamış, her zaman ökaristi ayininin vazgeçilmez bir parçası olarak kullanılmıştır. Eski ve Yeni Ahitten alınan konularla biçimlendirilen kapaklarda çoğunlukla İsa’nın çarmıha gerilmesi ve diriliş sahneleri işlenmiştir.

Araştırma konumuz olan Lola Törenhan Hanım’ın tarihi eser hazinelerinden çıkan kitap kapakları 1984 yılında Ankara Etnografya Müzesi’ne devredilmiştir. Müze deposunda yer alan iki gümüş kitap kapaklardan biri kitabeli olup Post-Bizans dönemine aittir, diğerinde ise herhangi bir kitabe bulunmamasına karşın eserin üslupsal özellikleri benzer örneklerle karşılaştırıldığında Ermeni kitap kapaklarını andırdığı düşünülmektedir. Çalışmadaki amacımız, bu gününe kadar çeşitli yayınlarda ve müze koleksiyonlarında ayrıntılı olarak incelenmemiş olan kitap kapaklarının gelişimini saptamak ve elde edilen sonuçlar ışığında Ankara Etnografya Müzesi’ndeki gümüş kitap kapaklarını tanıtmak sanat tarihi alanına bir parça da olsa katkı sağlayabilmektir.
The Impact of Geopolitics Risks on Macroeconomic Indicators: Evidence from Turkey
Authors: TUNA Fatih , ÇALIŞKAN Hande
Published: October 2022

The study aims to examine the effect of geopolitical risks on macroeconomic variables in Turkey using monthly data for the period from 1994 January to 2022 April. The global index calculated by Caldara and Iacoviello (2022) was used as an indicator of geopolitical risk. The industrial production index, inflation rate and real effective exchange rate were used as macroeconomic indicators. The relationships between the variables were researched with the frequency domain causality test developed by Breitung and Candelon (2009). The results of the analysis show that the inflation rate and the real effective exchange rate are affected by geopolitical risks in the medium and long term.