bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Value of a Scientific Document. Part 2
Authors: Lazarev Vladimir
Published: March 2024

After a critical consideration – through the prism of unspecified concepts of the value and quality of a scientific document – of examples of terminological confusion about the designation of a property of a scientific document represented by its citedness and use (that was given in the first part of the article), further consideration of the issue of the property being represented is provided. The need to continue the in-depth analysis and appropriate polemics as well as to strengthen the argument that the citedness of scientific documents directly represents their use, which, in its turn, represents their value, is caused by the fact that a number of experts either do not associate citation rate with value, or are indifferent to the issue of the property of documents represented by their citedness, or confuse the value of a document with its quality. Moreover, there is an authoritative point of view according to which the use is only one of the factors that cause scientific documents to be cited; while just access to experts' documents is considered, on the contrary, as an undoubted evidence of their use – though in this case it remains unknown whether the full text of the requested document would be at least briefly browsed by the user. The author gives a critical consideration of these issues. An opinion is expressed that a certain misunderstanding of the concept “use of a document” is due to its involuntary confusion with the traditional library concept “use of a library stock”. It is also shown that taking the philosophical notion of value for consideration can add even more confusion to the terminology used to denote a property of a scientific document represented by its citedness par excellence. The author makes an attempt to clarify the concepts and content of the terms “value of a scientific document” and “use of a scientific document”.
Searching for the Foundations of the Sociology of Suffering: Between Existential and Social Experience
Authors: Popov Evgeniy
Published: March 2024

Sociology of suﬀering is a branch of sociological knowledge that has been activelydeveloping as of recently. There are certain difculties when it comes to conceptualizingthe problematic and object-subject feld of sociology of suﬀering. The aim of this articleis to analyze the specifcs pertaining to the search for the foundations of specializedsociology, to identify its theoretical and methodological orientation, to identify the key focal points of scientific discourse, and to touch on the history of its development. The search for the foundations of sociology of suffering is conducted not in the format of “fear- pain-suffering”. The article shows that it is through differentiating between two types of human experience that a more systematic understanding of the phenomenon of suffering is possible. At the same time, social experience is highlighted as a common cause, and the phenomenon of collective suffering is correlated with the alienation of individuals or their communities and groups from the common cause. The main conclusion of the article is that the search for the foundations of sociology of suffering should be conducted at the level of simultaneous assessment of the role of existential and social experience in the emergence and consolidation of suffering in human individual and collective existence. Solely putting emphasis on existence can steer sociology towards metaphysics or psychology. On the other hand, the systematization of only social experience within the framework of sociology of suffering can reduce social experience to that which is formally accumulated, and suffering itself to such that is “attributed” to communities and groups.
Analisis Pengukuran Kinerja Karyawan Berdasarkan Key Performance Indicator Dengan Pendekatan Human Resources Scorecard Pada Soerabaja45
Authors: Balqis Rosiana , B.P. Dwi Windradini , Sisbintari Ika
Published: March 2024

Pengukuran kinerja karyawan pada perusahaan Soerabaja45 belum cukup efektif untuk menjadi dasar pengambilan keputusan dalam penetapan strategi bisnis karena bersifat subjektif. Pengukuran kinerja karyawan yang dibutuhkan perlu menggunakan indikator yang lengkap, objektif dan dapat digunakan sebagai dasar strategi peningkatan kinerja karyawan. Metode yang digunakan dalam penelitian ini adalah human resources scorecard. Tujuan penelitian ini untuk mengukur kinerja karyawan berdasarkan key performance indicator dengan pendekatan human resources scorecard pada Soerabaja45. Pengukuran kinerja karyawan menggunakan teknik analytical hierarchy process atau pembobotan perbandingan berpasangan yang dilakukan oleh tim manajamen perusahaan berjumlah 4 orang selaku expert di bidang ini, selanjutnya menentukan skor terhadap key performance indicator yang telah ditentukan dengan traffic light system. Hasil wawancara dan olah data diketahui terdapat 16 key performance indicator pada Soerabaja45, dengan 6 key performance indicator mencapai kinerja yang baik, 8 key performance indicator mencapai kinerja cukup baik dan 2 key performance indicator dengan kinerja kurang baik.

Kata Kunci: Pengukuran Kinerja Karyawan, Human Resources Scorecard, Key Performance Indicator
Моделирование течения жидкости в трещиновато-пористой среде на основе модели дискретных сетей трещин и матрицы
Authors: Grigor'ev Fedor Vladimirovich
Published: March 2024

Приводится обзор подходов к моделированию фильтрации подземных вод в трещиновато-пористых средах, обсуждаются их достоинства и недостатки. Описывается DFM-модель, реализованная в программном комплексе GeRa. Данный подход позволяет явно учитывать геометрию трещин и водообмен между трещинами и пористой матрицей. Предлагается использование многоточечной аппроксимации потоков на трещине методом конечных объемов на основе О-схемы. Демонстрируется применение реализованной численной схемы к решению практической задачи оценки водопритока к подземным выработкам в трещиноватом горном массиве.
NEGOTIATING MODERN ISLAMIC IDENTITY: The Political and Sociological Dynamics of Niqabis in Indonesia and Egypt
Authors: Qibtiyah Alimatul , Dzuhayatin Siti Ruhaini , Bouras Naima , Noorkamilah Noorkamilah
Published: March 2024

Type the Arab Springs and the rise of Daesh in Syria and Iraq gave the niqabi women a   special stand and visibility they never had before. Some niqabis women became visible sharing during the demonstrations calling for justice and social changes, others who believe in the Salafi jihadi trend were intensely mediatised due to their implication, next to Daesh, in tortures and bomb attacks. The civil societies in Egypt and Indonesia started to shape new calls to ban niqâb and presented it as a danger for the country. In both countries’ controversy has raised among Islamic mass organizations and universities. The Salafi doctrine which control women to cover the body including the face have increased in Egypt by the 70’ and in Indonesia during the 90’. It has entailed deep socio-religious norms’ transformations in both countries, with different impacts. This research focuses on how niqabis negotiate their modern identities in Indonesia and Egypt. It employs mixed method and uses surveys, in-depth interview (life stories), and focus group discussion. This paper would like to expose some results of those investigations happened in Indonesia and Egypt from June to November 2018.
Reaching A Million Barrels in an Abu Dhabi Field by Focusing on Operations Efficiency
Authors: Akhtar Masud J , Alhashmi Salem , Ofodile Azubuike , Al harthi Ghassan , Ali Naqbi Majid , Mishra Ashutosh , Senaini Amer , Al Shehhi Ease
Published: March 2024

In November 2021, the overall injection in this ADNOC Onshore field had dropped to its lowest ever level at 506 mbd. As production growth was expected over the next 5 years drastic steps needed to be taken to not only increase the water injection (WI) capacity but also improve the operations efficiency. This paper will provide details of how the asset achieved this as well as ended up doubling the injection volumes within 24 months.

There were 3 different methods where injection capacity could not only be increased but also sustained. These were adding new WI clusters (WIC), enhancing the capacity of existing clusters and improving the operational efficiency (OE). New WICs were already planned through existing ongoing Projects. Following close coordination between the Subsurface and Field Electrical Submersible Pumps (ESP) teams it was decided to do a proactive changeout of existing ESPs in water supply wells (WSW). Lastly OE was tackled through enhanced surface level agreement (SLA) with Drilling for well shut-in requirements, efficient replacement of failed ESPs in WSW's as well as quick repairs of flowline leaks, surface pumps and other operational issues.

7 new WICs were added between 2021 and 2023 through existing projects which added approximately ~175 mbd of capacity. Out of these all 7 WIC's have been commissioned and currently 6 are online. 2 WSW ESPs were proactively changed out by adding new ESP with higher capacity and more stages and this added ~20 mbd of capacity. The entire SLA was renegotiated with Drilling and was based on simulation modeling, interference testing followed by trials in pilot wells, and this added approximately ~20 mbd to overall OE. Previously, it would take 4-6 weeks to replace a failed ESP, and this was seen as an improvement opportunity and following close coordination between Subsurface, Operations and ESP team this time was reduced by 50% to 2-3 weeks. Lastly, the Operations team helped to deliver the largest OE improvement through effective management of repairs of flowline leaks, surface pump failures as well as other repairs. Overall, these changes resulted in the Field injecting over 1,000,000 bwpd with 24 months of record lows.

On average, one WIC was down every day due to flowline leaks. This was not sustainable, and a Leak detection task force was established to manage this. Instead of doing sectional flowline repairs, entire lengths were replaced. "Quick leak repair" methodology was developed and utilized in the Field. Lastly, successful pilots of using reinforced thermoplastic (RTP) flowlines were started in the Field and these are currently in evaluation phase with full field deployment expected soon. As a result of these changes flowlines leaks were reduced by over 50% and helped improve OE significantly.
Circularity & Decarbonization at A Seawater Injection System in the Oil & Gas Industry
Authors: Baatiyyah Hani M. , Abbas Ridha H. , Banna Rakan W.
Published: March 2024

The sea water injection department has a clear mission, which can be summarized in four main items: treat, transport, inject, and sustain. Let's take a closer look at each of these items to understand what they mean and why they are important.

Item 1: Treat The first item is "Treat". This refers to the process of treating sea water to make it suitable for injection into oil reservoirs. By treating sea water, we can ensure that it is safe and effective for use in oil recovery operations.

Item 2: Transport The second item is "Transport". This refers to the process of transporting the treated sea water from the treatment facility to the injection site. Efficient and reliable transportation is essential to ensure that the sea water is delivered to the injection site on time and in the right quantity.

Item 3: Inject The third item is "Inject". This refers to the process of injecting the treated sea water into oil reservoirs to enhance oil recovery. This is a key step in the oil recovery process, as the injected water helps to displace oil from the reservoir and push it towards the production well.

Item 4: Sustain The fourth and final item is "Sustain". This refers to the goal of sustaining oil recovery operations over the long time by using sustainable practices. This includes optimizing the use of water resources, minimizing waste and emissions, and reducing the environmental impact of oil recovery operations.
Challenges and Lesson Learned of Water Shut-Off Campaigns in Umm-Gudair Field in Kuwait
Authors: Al-Azmi Ali Abdullah , Abdul-Aziz Wejdan Jassem , Al-Yaqout Thanyan Ahmed
Published: March 2024

Umm Gudair field, West Kuwait onshore field has been on production for more than 60 years. MN-Oolite is an upper cretaceous carbonate reservoir, and it is the main reservoir in Umm Gudair Field. After a lengthy period of production, water production began to constrain and restrict oil production, and as a result, water production drastically raised the total operating costs of the field and overburdened the surface facility. In addition to this excess artificial lift horsepower demand for lifting fluids, corrosion-related concerns and well completion damage are on the rise.

In Um Gudair field, several mechanical and chemical water shut-off procedures were applied. Some of them were quite efficient and commendable in terms of increasing oil potential and decreasing water cut. However, this is not the case for all wells in the field; certain wells did not respond adequately to the mechanical water shutoff, primarily due to the conning effect, and required a different water shutoff strategy. In such situations, limiting water output by lowering the influence of water coning necessitates the use of a chemical polymer to form a chemical barrier.

This paper discusses the lessons gathered from more than 30 polymers water shut-off projects undertaken in Umm Gudair field during the past three decades. A rigorous research was undertaken with a precise diagnosis, information integration, and historical well work-over and completion, production, and reservoir data integration. All data is centralized, processed, and reviewed prior to and after water shut-off treatments in order to extract lessons learned for future projects.

The study indicates that the crosslinked polymer treatment is beneficial for a period of time in reducing water generation. In certain circumstances, the water cut may progressively increase, and in some cases, it will reach the pre-treatment level. In addition, the results indicate that the cross-linked polymer can improve well integrity by obstructing tiny cement channels. With high production rates, a high oil viscosity ratio, and high vertical to horizontal permeability in the reservoir, the severity of the water cone influences the polymer, and it is increasing. The success of the treatment is contingent on a number of factors, including the depth of polymer penetration in the formation, rock petrophysics, formation heterogeneity, polymer characteristics, and the correct operation techniques and implementation.
Harnessing Data Science for Produced Water Estimation: Unleashing the Power of Data-Driven Techniques
Authors: Sumarto B. A. , Nugroho B. H. , Joenaedy M. A. , Akbar B. H. , Al-Aradi H. J. , Achmad P.
Published: March 2024

In the oil and gas industry, monitoring the percentage of water content in produced hydrocarbons is crucial to ensure optimal production quality control and prevent equipment damage. The accurate estimation of the water cut, representing the proportion of water produced relative to the total fluid volume extracted from oil and gas wells, is crucial for effective reservoir management and production optimization. It allows the Kuwait Oil Company (KOC) to come up with an optimized production strategy to minimize water production while maximizing oil recovery.

Management of water has a direct impact on the economic factor of oil field operations. Unwarranted water production can raise the lifting cost and efforts to manage, process, and dispose of the produced water. Having a system to monitor the water cut with an accurate estimation helps optimize the cost, utilizes the resources effectively, allows planning and design of facility ahead of time to provide sufficient capacity and efficient processes and equipment, helps KOC to comply with the environmental regulations on disposing of the produced water, and enable informed decision making for reservoir management and development.

The water cut from production tests such as Portable Gas Oil Ratio (PGOR) is considered the most accurate. It is acquired approximately 3-4 times a year for each producing well and therefore cannot provide continuous water cut monitoring. Downhole sensor data including pressure discharge provide real-time data on reservoir dynamics and fluid behavior within the well. By strategically deploying, an array of these sensors along the wellbore, valuable insights into liquid composition can be obtained, offering the potential for accurate water cut estimation.
Effect of Different Activation Techniques of Calcium Silicate-Based Sealer on Root Canal Filling Quality and Sealer Extrusion Using Single-Cone Obturation Technique
Authors: Mohamed Mohamed Samir , El-Asfouri Assoc. Prof. Dr. Heba , El-Sayed Yassmin
Published: March 2024

Aim of the study:
The purpose of this study is to evaluate the effect of sealer activation by direct, indirect ultrasonic and XP-Endo Finisher file activation on the filling quality and sealer extrusion of the single-cone obturation technique in single rooted premolars with oval canals and compare it to no activation.
PICO approach
P: Population:
Single rooted premolars with oval canal.
I: Intervention:
I1 Indirect ultrasonic activation of sealer
I2 Direct activation of sealer by ultrasonic tip
I3 Direct activation of sealer by XP-Endo Finisher file
C: Control:
Single-cone obturation without sealer activation
O: Outcome:
Primary outcome: Quality of filling (presence of voids)
Secondary outcome: Weight of extruded sealer
Engineered Extracellular Vesicles from LncEEF1G Overexpressing Mesenchymal Stem Cells Promote Fibrotic Liver Regeneration by Upregulating HGF Release of Hepatic Stellate Cells
Authors: Zheng Jun , Zhang Jiebin , Lei Yunguo , Liu Xiaoquan , Qiu Xiaotong , Chen Haitian , Li Rong , Wang Tingting , Sui Xin , Xiao Jiaqi , Jiang Chenhao , Zhang Huayao , Liu Yasong , Zhang Yingcai , Yao Jia , Che Xu , Lin Ye , Pan Zihao
Published: March 2024

Fibrosis is a critical cause for negatively affecting liver regeneration resulting in severe complications after liver surgery. However, there is still no effective treatment for promoting fibrotic liver regeneration adapting to clinical translation due to the ambiguous mechanism. Through miRNA microarray combined with the application of AAV6, we found the high expression of miR-181a-5p in the activated hepatic stellate cells (HSCs) to suppress the expression of hepatic growth factor (HGF) partially contributed to impaired the potential of regeneration in mice with hepatic fibrosis receiving a two-thirds partial hepatectomy (PHx). As a nanotherapeutic, mesenchymal stem cell-derived extracellular vesicles (MSC-EVs) have been verified as an effective treatment for liver regeneration. We revealed that MSC-EVs could also promote fibrotic liver regeneration via enriched lncEEF1G that acted as a competing endogenous RNA (ceRNA) to directly sponge miR-181a-5p leading to the upregulated expression of HGF of HSCs. Finally, the engineered MSC-EVs with high expression of lncEEF1G (lncEEF1GOE-EVs) were constructed exhibiting more potential for this model. In summary, our findings present that lncEEF1GOE-EVs exert nanotherapeutic capacity in promoting regeneration of fibrotic liver by modulating miR-181a-5p/HGF pathway of HSCs, which also highlights the available of EV-engineering technology for the population of hepatic fibrosis receiving hepatic surgery.
Association between triglyceride-glucose index and mortality in patients with cirrhosis: a retrospective cohort study
Authors: Ma Xin-Yi
Published: March 2024

Background
Insulin resistance is common in patients with end-stage chronic liver diseases, especially cirrhosis. The association between the triglyceride glucose (TyG) index, a reliable measure for surrogate marker for insulin resistance, and mortality among cirrhotic patients remains unclear.
Methods
This retrospective cohort study was based on the MIMIC-IV database. Adult cirrhotic patients were categorized into two groups based on the TyG index: the Q1 group (TyG index < 8.8) and the Q2 group (TyG index ≥ 8.8). The primary outcome was 28-day mortality, and the secondary outcome was in-hospital mortality. COX proportional hazards model analyses were used to investigate the association between TyG index and mortality.
Results
The study included 1322 patients. The 28-day mortality was 17.9% in the Q1 group and 23.3% in the Q2 group. As categorical variable, elevated TyG index was associated with higher 28-day mortality (HR 1.422, 95% CI 1.098–1.841, P = 0.008) and in-hospital mortality (HR 1.442, 95% CI 1.118–1.859, P = 0.005). As continuous variable, every 1 unit increase in the TyG index was associated with increased 28-day mortality (HR 1.301, 95% CI 1.105–1.531, P = 0.002) and in-hospital mortality (HR 1.345, 95% CI 1.105–1.531, P < 0.001).
Conclusions
The TyG index was associated with increased mortality among patients with cirrhosis.
A study on the actor-partner effects between positive psychological capital and dyadic coping in breast cancer patients and their spouses
Authors: Zhang Shan , Liang Xin-hui , Wang Xin-yi , Ji Jin-rui , Bao Yu , Gao Fang-ning , Zhao Jie , Cao Bao-hua
Published: March 2024

Background As a protective factor, positive psychological capital is closely related to physical and mental health. However, existing studies lack analysis from the perspective of patient-spouse interactions. This study aims to explore the effects of positive psychological capital and dyadic coping in breast cancer patients and their spouses by constructing an actor-partner interdependence model.
Methods Using a convenient sampling method, 249 couples with breast cancer who were admitted to three tertiary hospitals in Xi 'an from October to December 2023 were recruited for investigation. The Chinese version of the Positive Psychological Capital Questionnaire and Dyadic Coping Inventory were used to measure the positive psychological capital and dyadic coping of breast cancer patients and their spouses. An actor–partner interdependence model was constructed to identify the interaction between positive psychological capital and dyadic coping of patients and spouses.
Results The positive psychological capital scores of breast cancer patients and their spouses were (122.59±15.98) and (130.01±15.53), respectively. Patients' positive psychological capital scores were lower than their spouses (P＜0.001). The tenacity dimension score of the patients was (3.93±0.89), which was no significant difference from the theoretical median value of the scale (t=1.324, P=0.188).The dyadic coping scores were (121.09±15.66) and (123.47±14.10), respectively, between the cut-off points of 111 and 145. The score of the spouses’ stress communication was lower than that of their spouses（P＜0.05）, and there was no significant difference between the other dimensions (P > 0.05). Regarding the actor–partner effect, patients and their spouse's positive psychological capital can positively predict their own and their spouses' dyadic coping (P < 0.05).
Conclusion We found that the positive psychological capital and dyadic coping scores of breast cancer patients and their spouses were both at a moderate level, and the tenacity dimension scores were the lowest in the positive psychological capital of patients. The findings highlight that the dyadic coping of couples is affected by individuals and their spouses' positive psychological capital.
Predictors of weight and waist gain in US South Asians: Findings from the Mediators of Atherosclerosis in South Asians Living in America (MASALA) Study
Authors: Seetharaman Sujatha , Allen Isabel , Gadgil Meghana , Sriniva Shylaja , Topor Lisa , Kanaya Alka
Published: March 2024

Background. Weight and waist gain are significant concerns in adulthood. Both weight and waist gain are particularly important among South Asians, a high-risk group known to develop chronic cardiometabolic complications at any body mass index compared to other racial and ethnic groups.
Objective. The aim of this study was to investigate factors predicting weight and waist gain in a longitudinal cohort of US South Asians, a high-risk group for developing obesity-related complications.
Methods. We used data from Mediators of Atherosclerosis in South Asians Living in America study (MASALA) exam 1 (2010-2013) and exam 2 (2015-2018), with a mean 4.8 years of follow-up.
Results. Of 634 participants studied (42.7% women, mean age 55 years, BMI 25.7 kg/m2, weight 70.4 kg at exam 1), 34.7% had gained ≥5% weight and 32.3% gained ≥5% waist at exam 2. In the adjusted models, older age, higher number of years of US residence, and having diabetes were associated with lower odds of weight gain; being female and having higher adiponectin were associated with higher odds of weight gain. Being female, employed full or part time, or retired were associated with lower odds of waist gain. Being single, separated/divorced, having a higher leptin and a higher C-reactive protein level were associated with higher odds of waist gain.
Conclusions. South Asian subgroups with higher risk of weight and/or waist gain may benefit from targeted interventions to improve health outcomes.
Conditional survival after radiofrequency ablation for early-stage hepatocellular carcinoma
Authors: Yen Yi-Hao , Moi Sin‑Hua , Kee Kwong-Ming , Hung Chao-Hung , Chen Chien-Hung , Hu Tsung-Hui , Wang Jing-Houng , Lin Chih-Yun
Published: March 2024

We analyzed how conditional survival (CS) after radiofrequency ablation (RFA) for early-stage hepatocellular carcinoma (HCC) predicts survival estimates over time.
We enrolled 791 patients with newly diagnosed early‐stage HCC (i.e., within Milan criteria) and Child–Pugh class A liver disease undergoing RFA. Three-year CS, calculated as CS = S(x+3)/S(x), was the probability of surviving an additional three years, given that the patient had already survived x years. One-, three-, and five-year overall survival rates were 96.3%, 72.3%, and 59.7%, respectively, and were lower for patients with a MELD score of >9, BCLC stage A disease, and AFP level of ≥20 ng/ml. However, three-year CS showed that patients ablated for BCLC stage A or AFP ≥20 ng/ml had the same survival probabilities as patients with BCLC stage 0 or AFP <20 ng/ml from the third year onward after RFA. In contrast, the three-year CS of patients with a MELD score of ≤9 was always better than that of patients with a MELD score of >9. We concluded that CS showed that the impact of different variables on survival after RFA is not linear over time. Information derived from CS can be used to dynamically predict the prognosis of patients with HCC.
The Influence of Climatic and Edaphic Factors on Growth of Farm Grown Teak in Tamil Nadu, India
Authors: Rajah R Ashick , Radhakrishnan S. , Balasubramanian A. , Balamurugan J. , Ravi R. , Sivakumar B. , Hariprasath C.N. , Swathiga G. , Navaneethakrishnan S. , Abbas Ghazanfer , Vasanth V , Bora Nilav , Patil Pragati
Published: March 2024

Teak (Tectona grandis, Linn.f) is a prized hardwood species with remarkable properties that make it a favored material in various industries. In current trend, the cultivation of teak in farmlands is considered as a promising and viable option. But the documentation and research on growth attributes and the studies on influence of climatic and edaphic factors on growth of teak raised in farmland condition is lacking. In this regard, the present investigation on farm grown teak was perpetrated in three agroclimatic zones viz., High Rainfall Zone (HRZ), Southern Zone (SZ) and Cauvery Delta Zone (CDZ) of Tamil Nadu in four different age classes (0-5, 5-10, 10-15 and 15-20 years). The study was carried forward with the prime motive of determining growth attributes and analyzing the impact of climatic and edaphic parameters on growth biometry of farm raised teak, both in block and boundary plantations. The soil physico-chemical parameters were analyzed both in surface (0-15 cm) and subsurface (15-30 cm) of farm grown teak plantations and the outcomes exposed that maximum organic carbon (0.62%), available nitrogen (197 Kg ha-1), available phosphorous (22 Kg ha-1) and available potassium (340 Kg ha-1) were observed in surface soils of high rainfall zone. Meanwhile maximum pH (8.30) and electrical conductivity (0.24 dS/m) were observed in southern zone. The follow-up of correlation studies between growth and climatic variables brought to light that tree volume positively correlated with climatic parameters viz., annual rainfall, mean maximum temperature, mean minimum temperature and mean relative humidity in both boundary and block plantations. Harmoniously, the correlation analysis between growth and edaphic parameters showed positive correlation with edaphic variables viz., organic carbon, available nitrogen, available phosphorous and available potassium, whereas growth depicted negative correlation with pH and electrical conductivity in both boundary and block plantations.
APOLLO: A Proximity-Oriented Low-Level Orchestration Algorithm for Performance Optimization in Mist Computing
Authors: Babaghayou Messaoud , Chaib Noureddine , Maglaras Leandros , Yigit Yagmur , Ferrag Mohamed Amine , Marsh Carol , Moradpoor Naghmeh
Published: March 2024

The fusion of satellite technologies with the Internet of Things (IoT) has propelled the evolution of mobile computing, ushering in novel communication paradigms and data management strategies. Within this landscape, the efficient management of computationally intensive tasks in satellite-enabled mist computing environments emerges as a critical challenge. These tasks, spanning from optimizing satellite communication to facilitating blockchain-based IoT processes, necessitate substantial computational resources and timely execution. To address this challenge, we introduce APOLLO, a novel low-layer orchestration algorithm explicitly tailored for satellite mist computing environments. APOLLO leverages proximity-driven decision-making and load balancing to optimize task deployment and performance. We assess APOLLO's efficacy across various configurations of mist layer devices while employing a round-robin principle for equitable task distribution among the close low-layer satellites. Our findings underscore APOLLO's promising outcomes in terms of reduced energy consumption, minimized end-to-end delay, and optimized network resource utilization, particularly in targeted scenarios. However, the evaluation also reveals avenues for refinement, notably in CPU utilization and slightly low tasks success rates. Our work contributes substantial insights into advancing task orchestration in satellite-enabled mist computing with more focus on energy and end-to-end sensitive applications, paving the way for more efficient, reliable, and sustainable satellite communication systems.
A RS-BOLGBM Algorithm Based on LightGBM for Supercomputing Center Job Running Status Prediction
Authors: Cao Ronghui , Tang Xiaoyong , Shi Cheng , Wu Yiming , Tan Deng , Liu Wenzheng , Huang Mingfeng
Published: March 2024

In recent years, more and more large-scale high-performance applications have been submitted to the Supercomputing Center for processing. These jobs often require intensive computations, and any running failure will lead to a lot of wasted costs. Therefore, the effective prediction of job running status will help to improve the resource management efficiency of the Supercomputing Center. In this paper, we first propose a combinatorial feature selection method combining ReliefF and SelectKBest, which can effectively obtain job running state features. Then, an improved LightGBM algorithm based on Bayesian hyperparameter optimization is proposed. This approach can further enhance the prediction accuracy and tuning efficiency. Thirdly, we achieve a RS-BOLGBM algorithm based on LightGBM for the Supercomputing Center job running status prediction on Spark. The experimental results show that our proposed RS-BOLGBM algorithm has good prediction accuracy on the common SWF (standard workloads format) dataset of the Supercomputing Center. Our proposed RS-BOLGBM also has good running efficiency on the Spark cluster.
Effect of pH and calcium chloride on the thermal inactivation kinetics and stability of chlorophyllase in mulberry leaves
Authors: Zhao Yali , Qian Shenye , Lu Jinwen , Liu Xintong , Cai Yingyu , Cao Xiamin , Liu Xunwen , Cai Chunfang
Published: March 2024

This study assessed the effect of pH (5.7, 6.8, and 8.0, adjusted using phosphate buffer) and calcium chloride (0.2 g/kg, 0.6 g/kg, and 1.0 g/kg) on the chlorophyllase (Chlase) activity and thermal inactivation in mulberry leaves at temperatures ranging from 75 ℃ to 100 ℃. The overall lethality was calculated, and the subsequent data were described using a two-fraction kinetics model. The results showed that the Chlase activity displayed an initial increase at a higher pH level and calcium chloride concentration, followed by a decline. Furthermore, the pH and calcium chloride also affected the Chlase inactivation kinetics. Weak acidity (pH 5.7) distinctly promoted Chlase inactivation during thermal treatment, while weakly alkaline conditions (pH 8.0) enhanced heat stability. The presence of calcium chloride increased the Chlase thermal stability, while the response to thermal processing (TP) varied depending on the calcium chloride concentration.
Analysis of solar energetic particle (SEP) event on the geomagnetic environment during 24th solar cycle
Authors: R Nirmal Kumar , C Ranjith Dev Inbaseelan , E Karthikeyan , M Nithyasree , H Johnson Jeyakumar
Published: March 2024

We report a study of major solar energetic particle (SEP) and ground level enhancement (GLE) events that occurred during the first 62 months of the rising phase of 24th solar cycle. Our objective is to comprehend the key factors that influence the severity and occurrence of such events. Coronal mass ejection (CME) speed (serves as or is) a reliable indicator of SEP and GLE events, as it consistently supports the shock acceleration mechanism. Some very fast CMEs, which likely have accelerated particles upto GeV energies, they may not result in a GLE event due to poor latitudinal connectivity. We have emphasized that the CME speed, magnetic connectivity to Earth, and ambient conditions as the main or primary factors that contribute to the lack of high-energy particle events during cycle 24. Furthermore, we observed that even well-connected fast CMEs that did not seem to have accelerated high-energy particles due to potentially unfavorable prevailing conditions such as high Alfven speed and overall reduction in acceleration efficiency in cycle 24. These conclusions are generally supported by insights gleaned from the observation of the time series of SW-IMF parameters on the flare day.
Next Generation Sequencing Panel as an Effective Approach to Genetic Testing in Patients with a Highly Variable Phenotype of Neuromuscular Disorders
Authors: Radziwonik-Fraczyk Wiktoria , Elert-Dobkowska Ewelina , Karpinski Marek , Pilch Jacek , Ziora-Jakutowicz Karolina , Kubalska Jolanta , Szczesniak Dominika , Stepniak Iwona , Zaremba Jacek , Sulek Anna
Published: March 2024

Neuromuscular disorders (NMDs) include a wide-range of diseases affecting the peripheral nervous system. The genetic diagnoses are increasingly obtained with using the next generation sequencing (NGS). We applied the custom-design targeted NGS panel including 89 genes, together with genotyping and multiplex ligation-dependent probe amplification (MLPA) to identify a genetic spectrum of NMDs in 52 Polish patients. As a result, the genetic diagnosis was determined by NGS panel in 29 patients so its diagnostic utility is estimated at 55.8%. The most pathogenic variants were found in CLCN1, followed by CAPN3, SCN4A, and SGCA genes. Genotyping of myotonic dystrophy type 1 and 2 (DM1 and DM2) as a secondary approach has been performed. The co-occurrence of CAPN3 and CNBP mutations in one patient as well as DYSF and CNBP mutations in another suggests the ‘’double-trouble’’ diagnosis. In 7 individuals with single nucleotide variant found in NGS testing, the MLPA of the CAPN3 gene was performed detecting the deletion encompassing exons 2–8 in the CAPN3 gene in one patient, confirming recessive limb-girdle muscular dystrophy type 1 (LGMDR1). Thirty patients obtained a genetic diagnosis (57.7%) after using NGS testing, genotyping and MLPA analysis. The study allowed for the identification of 27 known and 4 novel pathogenic/likely pathogenic variants and variants of uncertain significance (VUS) associated with NMDs. In conclusion, the diagnostic approach with diverse molecular techniques enables to broaden the mutational spectrum and maximizes the diagnostic yield. Furthermore, the co-occurrence of DM2 and LGMD has been detected in 2 individuals.
Complete thrombosis of a bioprosthetic mitral valve and left atrium in a patient on venoarterial extracorporeal membrane oxygenation with favorable outcome
Authors: Hall James , Khilkin Michael , Abrol Sunil
Published: March 2024

Intra-cardiac thrombosis is a potentially devastating complication of extracorporeal membrane oxygenation (ECMO) mechanical circulatory support. We present here a patient who suffered complete thrombosis of a fresh mitral prosthesis and left atrium in the setting of ECMO with aortic insufficiency who was treated with repeat valve replacement and thrombectomy. To our knowledge, she is the only patient in the reported to have survived this complication.
Exploring Lifestyle Activities as Possible Protective Factors for Life Satisfaction: A Cross-sectional Study
Authors: Sakimoto Fumio , Doi Takehiko , Katayama Osamu , Matsuda Soichiro , Makino Keitaro , Shimada Hiroyuki
Published: March 2024

Background and objective:
Life satisfaction is an important factor in maintaining or increasing healthy life expectancy. However, as it is unclear what activities are associated with life satisfaction in older adults, we investigated whether lifestyle activity engagement contributes to higher life satisfaction levels.
Methods
The study participants were 4,167 community-dwelling older adults aged 60 years or above in a cross-sectional survey. Life satisfaction was assessed using the Life Satisfaction Scale, which contains 13 questions, each comprising four levels. A 36-item Lifestyle Activities Questionnaire was used to assess participants’ lifestyle activities, with 12 items each covering physical, cognitive, and social activities. The results of each activity were categorized into high-, moderate-, or low-activity tertiles to determine their association with life satisfaction. The relationship between life satisfaction and each activity type was also examined by stratifying the associated characteristics (i.e., living alone, gender, and age).
Results
The logistic regression analysis adjusted for covariates showed that physical, cognitive, and social activities had protective effects on life satisfaction. The high activity group had a lower odds ratio (OR) for low life satisfaction compared with the low-activity group (physical activity: moderate group OR 0.87, 95% confidence intervals (CI) 0.73–1.03, high group OR 0.78, 95% CI 0.65–0.92; cognitive activity: moderate group OR 0.88, 95% CI 0.74–1.04, high group OR 0.67, 95% CI 0.56–0.81; social activity: moderate group OR 0.74, 95% CI 0.62–0.88, high group OR 0.63, 95% CI 0.52–0.75). The stratified analysis revealed different associations under each stratum, with only social activities demonstrating a protective effect on life satisfaction across all strata.
Conclusion
High engagement in lifestyle activities had a protective effect on life satisfaction. The differences in the relationship between each activity type and life satisfaction varied based on participants’ characteristics. To maintain life satisfaction, it is necessary to understand the contribution of different activity types and the individual characteristics of the target population.
Genome-wide association studies and mapping of ROH identifies candidate genes for growth traits in hybrid rabbits
Authors: Jia Xianbo , Xiao Zhanjun , Li Yuchao , Yang Li , Sun Wenqiang , Wang Jie , Chen Shiyi , Lai Songjia
Published: March 2024

Screening and identifying genes related to growth traits are critically important for the production of meat rabbits. Genome-wide association studies is an effective method for large-scale screening of genetic markers related to target traits. However, the performance of whole-genome association studies in meat rabbits candidate genes associated with the heterosis remains largely unknown. In this study, after quality control and filtering of genotype data, a total of 380 F2 hybrid rabbits (205 male rabbits, 175 female rabbits) with 78579 SNPs and 42018 ROH on the autosome were obtained. The phenotypic values and heterosis of 380 F2 hybrid rabbits at seven growth stages were compared and analyzed. The fitting of the Logistic growth curve model indicated that the rabbit at 49 days of age was a growth inflection point. At this time, the correlation between weight heterosis and ROH was − 0.1267 to 0.07436. Ultimately, we conducted a genome-wide association studies of genotypes and growth trait heterosis after quality control using a mixed linear model. A total of 10 significant SNP-sites were significantly associated with weight at 84 days of age, and 7 candidate genes associated with growth traits were identified in meat rabbits. Additionally, we also uncovering the functional roles and positions of 20 candidate genes associated with economic traits of meat rabbits in high-frequency ROH regions. This study identified potential genes related to meat rabbit growth, development and adaptability in high-frequency ROH regions. These research findings will provide a genomic reference and new insights for the selection and improvement of hybrid meat rabbits, as well as useful genetic markers for breeding important economic traits in domestic rabbits.
Protective Effects of Lemon Leaf and Limonene against Indomethacin-Induced Gastric Ulcers in Rats: An In Vivo and In Silico Study
Authors: Aggul Ahmet Gokhan , Duysak Lale , Gulaboglu Mine , Parlar Seyma Gozde , Kutlu Zerrin , Albayrak Ali Ihsan
Published: March 2024

This paper aims to assess the possible protective effects of the lemon leaves and its main component, limonene, which is known for its active principles and health benefits, against indomethacin-induced oxidative stress in the rats. In this study, the rats were given the ethanol extract from the lemon (Citrus L.) leaf and famotidine, a medication used for treating duodenal and gastric ulcers. The extracts (0.25, 0.5, and 1 g/kg) and/or famotidine (20 mg/kg) were administered to the treated rats via oral gavage at the doses determined for each group. Five minutes later, the rats were orally given a single dose of indomethacin (25 mg/kg). After six hours, the stomach tissues of the rats were collected for biochemical analysis. The treatment significantly improved gastric ulcer conditions by reducing oxidative stress, a key contributor to ulcer formation. Notably, the rats that received the highest dose of the extract exhibited significantly reduced MDA levels, an indicator of oxidative stress, in comparison to the control group. Furthermore, these rats showed a significant increase in SOD activities and GSH levels. The present study also focused on the mechanism underlying the gastroprotective action of limonene, a primary component of Citrus L., against PGE2, Na+/K+-ATPase, and H+/K+-ATPase under in silico conditions. The findings from this study might have significant implications for treating numerous global health disorders due to the antioxidant properties of the ethanol extract from the lemon leaf.
Prevalence and influencing factors of sleep disorders in medical students after the COVID-19 pandemic
Authors: Liu Jiao , Li Baozhu , Zhang Ran , Luo Guoshuai , Sun Daliang
Published: March 2024

Background
The prevalence of sleep disorders among medical students was high during the COVID-19 pandemic. However, there are fewer studies of sleep disorders in medical students after the COVID-19 pandemic. This study aimed to investigate the prevalence and factors influencing sleep disorders among Chinese medical students after COVID-19.
Methods
We enrolled 1194 medical students. The Self-administered scale was used to collect the demographic characteristics. The Self-rating Depression Scale (SDS), the Self-rating Anxiety Scale (SAS), and the Pittsburgh Sleep Quality Index (PSQI) were used to assess subjects' depression, anxiety, and sleep disorders, respectively. The chi-square test and binary logistic regression were used to identify factors that influence sleep disorders. The receiver operating characteristic (ROC) curve was used to assess the predictive value of relevant variables for sleep disorders.
Results
We found that the prevalence of sleep disorders among medical students after COVID-19 was 82.3%. According to logistic regression results, medical students with depression were 1.151 times more likely to have sleep disorders than those without depression (OR = 1.151, 95% CI 1.114 to 1.188). Doctoral students were 1.908 times more likely to have sleep disorders than graduate and undergraduate students (OR = 1.908, 95% CI 1.264 to 2.880). In addition, the area under the ROC curve for depression is 0.689.
Conclusion
The prevalence of sleep disorders among medical students is high after COVID-19. In addition, high academic level and depression are risk factors for sleep disorders. Therefore, medical colleges and administrators should pay more attention to sleep disorders in medical students after the COVID-19 pandemic. Regular assessment of sleep disorders and depression is extremely necessary.
Development and Validation of Stability Indicating HPTLC Method for Simultaneous Estimation of Dapagliflozin and Linagliptin
Authors: Shukla Anchal , Chhalotiya Usmangani K. , Shah Dimal , Tandel Jinal , Kachhiya Heta , Parmar Mital
Published: March 2024

For the treatment of Type 2 Diabetes Mellitus, Dapagliflozin selectively inhibits the sodium-glucose co-transporter-2, while Linagliptin competitively and reversibly inhibits dipeptidyl peptidase-4 in a fixed dose combination (1:1). Dapagliflozin and Linagliptin estimation in bulk and tablet formulation was accomplished by the development and validation of a precise and accurate HPTLC method. The procedure used Toluene: Chloroform: Methanol: Triethylamine (7:2:1:0.2 v/v/v) as the mobile phase and HPTLC aluminum plates pre-coated with silica gel 60 F254 as the stationary phase used. Dapagliflozin and Linagliptin were determined to have Rf values of 0.23 and 0.40 correspondingly. At 224 nm, densitometric analysis was performed in the absorbance mode. For Dapagliflozin and Linagliptin 200–1200 ng/band were the linear ranges in which the procedure produced results. Forced degradation studies were performed on both Dapagliflozin and Linagliptin active pharmaceutical ingredients like acid hydrolysis, base hydrolysis, chemical oxidation, dry heat and photodegradation studies. Dapagliflozin and Linagliptin are susceptible to acid hydrolysis, base hydrolysis, chemical oxidation while both the chemical substances are stable to dry heat and photolytic studies.