bluuebunny/crossref_metadata_2025 huggingface dataset:
Inversion of Gravity Anomalies by Cuckoo Search Algorithm
Authors: TURAN KARAOĞLAN Seçil , GÖKTÜRKLER Gökhan
Published: September 2022

Metasezgisel algoritmalar jeofizik ters çözüm çalışmalarında sıklıkla kullanılır duruma gelmiştir. Türev tabanlı en iyileme yöntemlerinin aksine, iyi bir başlangıç modeline ihtiyaç duymayan arama algoritmaları parametre uzayını kapsamlı tarama özelliğine sahip olduklarından jeofizikte model parametre kestirimleri için avantaj sağlamaktadır. Sunulan çalışmada, gravite anomalilerinin ters çözümünde guguk kuşu arama algoritması kullanılmıştır. Algoritmanın kullanıcı tanımlı parametre sayısının az olması ve yapılan literatür taramasında doğadan esinlenilerek oluşturulan birçok metasezgisel yönteme göre daha iyi sonuç vermesi, parametre kestirim çalışmasında guguk kuşu algoritmasının kullanılmasını teşvik etmektedir. Gravite belirtisine ait genlik katsayısı, kaynak derinliği, belirti izdüşümü ve şekil faktörleri kestirimi yapılan model parametreleridir. Algoritmaya ait kontrol parametreleri (popülasyon sayısı ve yumurtanın yuvadan atılma olasılığı) ise gürültüsüz kuramsal veri kümesi kullanılarak parametre belirleme çalışmaları (parameter tuning) ile detaylı bir şekilde irdelenmiştir. Sonrasında kontrol parametre çiftinin doğruluğu gürültü içeren veri kümesi üzerinde test edilmiştir. Ardından, Küba’da bir kromit yatağı üzerinde ölçülen arazi verisi ve Kanada’da yer alan bir sülfit cevheri üzerinde ölçülen arazi verisi değerlendirilerek, anomalilere ait model parametreleri kestirilmiştir. Kuramsal ve arazi veri kümelerine ait model parametrelerinin güvenilirliğinin belirlenmesi için, Metropolis-Hasting algoritması kullanılarak, kestirim parametreleri istatistiksel olarak da test edilmiştir. Doğası gereği iyi bir başlangıç modeline ve model parametrelerine göre kısmi türev hesabına ihtiyaç duymayan algoritma, kullanıcı tanımlı iki parametre içermesi sayesinde parametre kestirim çalışmalarında kolaylık sağlamıştır. Yapılan belirsizlik analizleri sonucunda da algoritmanın gravite verilerinin ters çözümünde uygulanabilir bir algoritma olduğu belirlenmiştir.
Corrosion Performance Investigation of Reinforcement Bars Coated with Cement and Mineral Admixture Slurry
Authors: YİĞİTER Hüseyin
Published: September 2022

Reinforcement corrosion is considered as one of the most important parameters determining the service life of reinforced concrete structures. In this study, an alternative method that protects reinforced concrete reinforcements against the effects of corrosion has been examined. Within the scope of the study, in addition to the traditionally produced reference reinforced concrete samples, reinforced concrete samples produced with mineral additive cement slurry coated reinforcements were prepared. In addition to silica fume at 30% of the cement amount by mass, blast furnace slag at 25% and 50% of the cement amount was used in mineral added cement slurries. According to the test results, it was determined that the slurry coating application decreased the corrosion potential values and the corrosion current density values of the reinforcements in the samples exposed to the wetting and drying cycles in the sodium chloride environment.
Investigation of Microstructure and Mechanical Properties of ETP Copper Deformed by Equal Channel Angular Pressing (ECAP)
Authors: ATAN Ebubekir
Published: September 2022

Severe plastic deformation (SPD), the plastic deformation of materials under high pressure, is used to improve the mechanical and structural properties of materials. Equal Channel Angular Pressing (ECAP) is one of these methods used to produce materials microstructure with submicron or nano-sized grains by applying high pressure to the sample passing through two angular intersecting channels with the same diameters. In recent years, studies on the production of nano-grained metallic materials have increased. The aim of this study is to examine the gradual change of the microstructure and mechanical properties of the material under high pressure and to determine the effect of ECAP on the improvement of these properties. This process is directly related to the internal structure and texture of the material. With the applied method, it is aimed to obtain a more durable material structure. Electrolytic Tough Pitch (ETP) copper material, which is one of the copper types commonly used in electrical applications, was chosen in the study. 12 mm diameter and 35 mm long ETP copper samples, which were not subjected to any heat treatment, processed on 2 mm/s pressing speed, 200°C mold temperature and Bc ECAP route using a 120 ton capacity hydraulic press, a precision machined mold which has 120° (Φ=120°, ψ=20°) channel angle. The changes in the crystal structure, microstructure and mechanical properties of the ECAP applied samples were investigated. According to the data obtained, it was observed that the 4 passes of ECAP application resulted in having finer grains in microstructure and improvement in mechanical properties.
Jant Tasarım Parametrizasyonu ve Parametrizasyonun Optimizasyona Etkisi
Authors: ÖZDEMİR Yusuf Burak , KARPUZCU Yalçın , ÇAM Serhat , GÜNPINAR Erkan
Published: September 2022

Jantlar arabanın önemli bir parçasıdır ve tekerlekler ile birlikte arabanın ve yolcularının yükünü taşırlar. Bu yükü taşımak ve olası bir kazada can kaybını önlemek için jantın sağlam olması gerekli ve önemlidir. Diğer taraftan estetik açıdan da göze hitap etmelidir. Bu çalışmada öncelikle araba jantının sınır koşulları belirlenmiştir. Bu sınırlar içerisinde farklı jant tasarımları elde edebilmek için bir kullanıcı çalışması gerçekleştirilmiştir. Kullanıcı çalışmasındaki her bir katılımcı bir model tasarlamış ve parametrize etmiştir. Jant telinin sayısı, şekli ve göbek kalınlığı gibi tasarım parametreleri kullanıcı tarafından belirtilmiştir. Sonrasında kullanıcılardan bu parametreler kullanarak jeneratif tasarım yoluyla birbirinden farklı 20 tane jant modeli elde etmeleri istenmiştir. Durağan arabanın etki ettiği kuvvetler altında (parametrik olarak elde edilen) jantlar modellerinin gerilme ve yer değiştirme dağılımını bulmak için sonlu elemanlar yöntemi (FEM) kullanılmıştır. FEM kullanırken, ağ elemanlarının sayısına ve analiz edilen jantın yönüne dikkat edilmiştir. Jantlar tasarım kabiliyetine sahip gönüllü birisinin verdiği estetik puanlara ve FEM testlerinden elde edilen stres ve yer değiştirme değerlerine göre sıralanmıştır. Sıralamanın ardından genetik algoritma (GA) kullanılarak farklı ve estetik modeller elde edilip, kullanıcıya sunulmuş ve seçimi ile en uygun jant tasarım(lar)ı elde edilmiştir. Bu optimizasyon çalışması parametrizasyonu yapılmış iki farklı jant modeli kullanılarak yapılmıştır. Sonuçlar incelendiğinde parametrizasyon optimizasyon sonrası elde edilen modellerin performanslarını etkilemektedir.
Değişken Çevrimli Mikro Turbofan Jet Motoru için Bütünleşik Düşük Basınç Kompresor Sisteminin Aerodinamik Analizleri
Authors: GÜRBÜZ Muhammet Tayyip , ACARER Sercan
Published: September 2022

Unmanned Aerial Vehicles (UAVs) are commonly propeller-driven and low-speed. The concept of cost-efficient, much higher speed and longer range applications of micro jet engines was previously addressed such that an existing basic turbojet engine was converted into a single spool turbofan without using additional components of booster and low pressure turbine. Normally, this situation emerges matching problems since two spools are required to adjust the fan speed independently. A simple solution was to use a Continuously Variable Transmission (CVT) gearbox to adjust optimal speed for the fan. As a result, missing of the positive functionality of the booster would lump into the fan root to form a unified low pressure compression system (unified-LPC). Such a unified-LPC demands unique characteristics of having an extreme twist, very high pressure ratio and mass flux at the root section than at the tip section, despite the exact opposite is being enforced due to the wheel speed rise with radius. In light of these challenges, this work aims to investigate detailed aerodynamics of an existing design previously made and reported by the authors. It is shown that, despite the aerodynamic loading contrast throughout the span, the unified-LPC can still have a wide operating range and acceptable off-design aerodynamics. Complementing the previous design-oriented work, this paper aims to provide guidelines for such unified compression systems.
Akut Lenfositik Löseminin Makine Öğrenimi Yöntemleriyle Otomatik Tespitine İlişkin Karşılaştırmalı Bir Çalışma
Authors: KOCATÜRK Canan , CANDEMİR Cemre , KOCABAŞ İlker
Published: September 2022

Acute Lymphocytic Leukemia (ALL) is one of the most prevalent types of leukemia which has the risk of death of children is relatively higher than adults. The early diagnosis of this disease is crucial and it can be detected by examining the morphological changes of the blood cells. In this study, we exhibit a comparative study on the automatic classification and identification of the ALL with machine learning methodologies. Acute Lymphoblastic Challange Database (ALL-CDB) served by the Cancer Imaging Archive, which consists of 6500 digital microscopic pathology images from 118 subjects, is used. As the first step, the geometric features are extracted and after, the feature selection was performed with Principal Component Analysis (PCA). Finally, the classification process on the selected features was carried out by using Naive Bayes, k-Nearest Neighbor (k-NN), Linear Discriminant Analysis (LDA), Decision Tree (DT), Random Forest (RF), Support Vector Machine (SVM), and Multilayer Perceptron (MLP) neural network methods. The results between the methodologies have been analyzed in terms of accuracy, precision, recall, and F1-score metrics. According to the results, MLP gives the both highest accuracy and F1-score with 97% to classify the ALL cells for leukemia.
Study on microstructure and mechanical performance of copper/brass brazing joint with Ag brazing fillers
Authors: ŞAFAK Gökhan , İRİZALP Simge , KÖROĞLU Burçak Kardelen
Published: September 2022

Ag is used as a useful alloying element in brazing filler metals. It is clear that the addition of Ag has a positive effect on the melting temperature, wettability, conductivity and mechanical property of the filler metals. For this reason, although Ag is very expensive, it is still widely used in many research and production. In this study, it was focused on obtaining both high strength and cost-effective brazing joints by using filler metals containing different levels of Ag. Melting-solidification temperatures, mechanical properties and microstructures of brazing joints obtained with filler metals containing different levels of Ag-Cu-Zn and Cd were investigated. In this study, the appropriate Ag content in brazing processes of pipes and caps used as copper-brass material pairing in cooling-heating devices in the air conditioning system was investigated in detail. When the typical microstructure of the joints was examined, it was observed that it mainly consisted of solid solutions and eutectic phases. The interfaces in the copper and brass regions were affected by both Ag content and melting temperatures. As a result of the burst test, the maximum stress value at which the brazed material pairs were damaged was found to be 345 MPa, and the damage was reported to occur in the copper pipe. In addition, it has been reported that the final product is damaged from the brazed zone when Ag-free solder wire is used. It was found that 5%Ag content provides sufficient performance in the final product due to the fact that the strength of the braze joint with low-Ag content is higher than the copper tube. The results also showed that the micro-hardness increased with the increase of Ag-addition, the hardness of the joint with the filler metal containing 5%Ag increased by 21%. The joint hardness obtained with filler metal containing 40% Ag showed an increase of up to 57%. This showed that the addition of Ag improves the strength, but its 5% Ag content provides sufficient performance in the brazing joint.
Moskovalainen. Ruotsi, Suomi ja Venäjä 1478–1721
Authors: Tarkiainen Kari
Published: September 2022

The Muscovite. Sweden, Finland and Russia 1478–1721 The great change in European relations with Russia took place in 1478 when Muscovy replaced the trading Republic of Novgorod as a neighbor of Sweden, Livonia and Lithuania. Western Europe was since that year bordering to a bellicose great power with large resources causing dread. The feelings of dread caused by Russia with Czars like Ivan the Terrible became a standing theme in printed matter as well as politics and the image of Russia became very much similar to the image of Turkey, which threatened Europe from South-East. Various, usually rather negative, stereotype expressions characterized the vocabulary of the 16th century. The Peace of Stolbova in 1617 started a period of successive change. The era of Sweden as a Great Power led to growing knowledge about Russia in almost every respect, but it was still based on the already accepted stereotypes. They started, however, typically to seem more diluted and thin with time. The image of Russia as a threat was to a growing extent replaced by an image of a possibility. The perhaps most remarkable but rather unoriginal printed Swedish description of Russia of the era was Regni Muschovotici Sciographia, published by Petrus Petrejus. At the final stage of Sweden’s era as a great power there was a substantial widening but also polarization of the information on Russia. The Russian reform process during Tsar Peter I also began to influence the minds after the turn of the century in 1700. One of the principal describers of this process was Lars Johan Malm (Ehrenmalm), whose large manuscript about the power of the Russian Empire of that time, Några Anmärkningar Angående det Ryska Rijkets Nuvarande Macht from 1714, never reached the printers due to intervention from censors.
A relação entre o ensino técnico e o propedêutico nas reformas e contrarreformas da educação brasileira
Authors: Dorneles Minuzzi Evelize , Regina de Souza Machado Lucília , Xavier Coutinho Renato
Published: September 2022

Este artigo tem como objetivo realizar uma retrospectiva histórica dos dispositivos legais, pertinentes à educação, surgidos entre 1909 e 2021, os quais são reveladores dos avanços e retrocessos quanto à articulação entre a educação profissional e a propedêutica. Com base em informações obtidas por meio de pesquisas bibliográficas e documentais e mediante a análise de conteúdo desses dispositivos, foram identificados cinco ciclos de política educacional, demarcações importantes para a compreensão dos limites interpostos à efetivação, no Brasil, da educação profissional pública, democrática, unitária, politécnica, omnilateral e emancipatória. Constatou-se não ter havido nenhuma articulação da educação profissional com a educação propedêutica no primeiro ciclo. No segundo foram identificadas equiparações, mas sem a efetiva integração entre essas ofertas educacionais. No terceiro observou-se o restabelecimento da lógica da separação. No quarto ciclo constatou-se avanços a favor da integração da educação profissional com a educação básica e na perspectiva da escola unitária e da formação politécnica e omnilateral. No quinto ciclo, em curso, assiste-se a uma contrarreforma educacional voltada à reafirmação da lógica da dualidade estrutural do ensino. Esses cinco ciclos evidenciaram como as contradições entre capital e trabalho se reproduzem na esfera da legislação educacional e imprimem movimento à história das políticas educacionais, desvelando seus avanços e recuos e a força do Estado como uma instância reguladora dos conflitos.
Escolhas ou escolhidos? Estudantes de camadas populares em uma escola técnica federal
Authors: Piotto Debora Cristina , Tetzlaff Iris Maria Bosco
Published: September 2022

O presente artigo discute o processo de escolha por uma escola de Ensino Médio Técnico Federal por parte das camadas populares. Partindo de estudos sobre a escolha do estabelecimento de ensino e acesso ao Ensino Superior em meios populares, foram realizadas entrevistas em profundidade com dez estudantes, pertencentes às camadas populares, do Instituto Federal de Educação, Ciência e Tecnologia de São Paulo (IFSP). Os resultados apontam que todos os estudantes entrevistados podem ser considerados “bons alunos” e que houve participação notadamente dos professores no processo de escolha pela escola, ao fornecer informações e incentivar o ingresso desses estudantes no IFSP. Revela-se que a escolha pela instituição federal por parte das camadas populares ocorreu por meio de um processo socialmente construído, sobretudo no âmbito escolar, no decorrer da escolarização dos estudantes.
Institutos federais e arte: mapeamento de uma relação
Authors: Fonseca do Amaral Carla Giane
Published: September 2022

O objetivo deste artigo é trazer um panorama de algumas relações possíveis entre o ensino de arte e a Educação Profissional oferecida nos Institutos Federais de Educação, Ciência e Tecnologia, problematizando a dualidade entre formação geral e formação profissional, diante da perspectiva da educação integrada. São apresentados dados analisados com o método da bricolagem em uma pesquisa qualitativa sobre a presença de docentes e cursos de Artes Visuais, Teatro, Dança e Música nos IFs, que aliados a uma discussão teórica sobre arte, poder e resistência baseada em Foucault, indicam que o ensino de arte pode se configurar como uma estratégia de resistência contra o modelo performativo neoliberal vigente nesse sistema de ensino.
Mast Cells Released Inflammatory Markers Play a Vital Role in Mandibular Remodeling of Odontogenic Keratocyst Patients
Authors: Malik Zulaikha , Mirza Armaghan Israr , Akram Muhammad Adnan , Arshad Adnan , Kiyani Amber
Published: September 2022

Background: Odontogenic Keratocyst (OKC) falls among the distinctive and rare odontogenic developmental cyst which is derivative of the dental lamina and contains clear fluid along with a cheesy material which resembles keratin debris.  Treatment strategies for OKC are for the most part classified as conservative or aggressive. Mast Cells play an important role in the pathogenesis of inflammatory conditions. Objective: The goal of our study was to observe the participation of inflammatory mediators (RANKL, TNF-α, TGF-β and MMP-9) in the pathogenesis as well as the recovery process of OKC. Methods: Enrolled patients were divided into three groups while a fourth group was formed of the control individuals. Sampling of all groups was done once after required data collection. Blood samples were taken, mRNA extraction and cDNA was then subjected to qRT-PCR. IHC for mast cells was done on patient samples. Results: qRT-PCR showed higher expressions of inflammatory markers in patients undergoing treatment as compared to individuals with completed treatment procedure. Levels of RANKL were high in patients that were currently undergoing bone development as compared to other patients. The levels of TNF-α were comparatively higher in patients who  showed visible signs of inflammation like swelling and pain. TGF-β and MMP-9 expression levels showed correlation with each other in all three groups. Both these cytokines were also found to be in association with mast cells. The results of histochemical staining of mast cells suggested the involvement of these cells in the pathogenesis of the cystic lesion via inflammation. Conclusions: The findings of the study suggest that the expressions of inflammatory mediators correlate with the presence of mast cells, therefore, application of mast cells stabilizers in addition to marsupialization in the treatment of OKC can be a prospective treatment strategy in future clinical settings.
Association of Attitude Towards Mental Illness with Exposure to Psychiatry in Medical Students
Authors: Azad Nadia , Mansoor Sawera , Abbas Nadeem , Ul Ain Qurrat
Published: September 2022

Background: Society's attitude towards patients with mental illness has been evolving over the past century and the speed of this evolution has particularly accelerated since the advent of modern ways of communication and media. As with other areas of development, attitude change may be expected to be slow-paced in our country but local evidence is lacking in this regard. Objective: To measure the level of stigma towards mental illness in medical students along with its association with their prior exposure to Psychiatry. Method: This is across-sectional study conducted between May to August 2019 at a private medical college. Consecutive sampling was used to include a total of 247 (71% female and 29% male) students of the fourth and final year MBBS after written informed consent. A specially designed form was used to collect relevant socio-demographic details along with data regarding exposure to Psychiatry. The scores from self-reported Mental Illness: Clinicians' Attitudes scale (MICA)were also recorded. Chi-Square test was used to assess the association of exposure to psychiatry to stigmatizing attitudes. Data were analyzed using SPSS20. Results: Prior exposure to mental illness in family or friend was reported by 60.5% of the students, 70% described an exposure through media and only 32% had undergone a clinical psychiatry rotation. Average stigma scores on MICA were found in 41% of our sample, while 32% had above-average scores and 27% had lower than average stigma. Pearson' schisquare test showed that the previous exposure to mental illness via media sources was found to be significantly associated with lower levels of stigma in medical students (p=
Histological Spectrums in Transurethral Resection of Bladder Tissue
Authors: Javaid Qurat ul Ain , Kamal Farrukh , Iqbal Munazza , Naz Asima , Iqbal Madiha , Kalsoom Farah
Published: September 2022

Background: Urinary bladder carcinoma is more common in elderly males than females. Urothelial (Transitional cell) carcinoma is the most common histological subtype. Objective: The purpose of present study was to describe the different histological features observed in transurethral resection of bladder tissue and to determine the association of tumor grade with stage and also of the age with grade and stage of tumor. Methods: An analytical Cross sectional study, conducted in the Department of Pathology Fatima Jinnah Medical University Lahore, Pakistan from August 2019 – April 2021. Total 80 specimens of transurethral resection of bladder tissue (TURBT)
were included. All the specimens were fixed in 10% formalin and stained with Hemotoxylin Eosin stain and studied under the light microscope. urinary bladder malignancies were classified, staged and graded according to the WHO/ISUP guidelines. Results: Total n=80 cases were included in the study. Mean age of the male patients was 59± 1.13 years and 50±1.1 years in females. N=76(95%) were malignant and only 4 (5%) were benign cases. Out of 76(95%) malignant cases, 48 (63.1%) were high grade urothelial carcinoma and 28 (36.8%) were low grade carcinoma. N=33 (43.4%) were invading the lamina propria (T1) and 43 (56.5%) were invading the detrusor muscle (T2).Low grade tumors showed lamina propria invasion (T1) in 18 (64.2%) cases and muscular invasion (T2) was seen in only 10(35.7%) cases. N=33(68.7%) of high grade tumor were invading the deep muscle (T2) and 15 (31.2%) were limited to lamina propria (T1). Tumor with high grade morphology were diagnosed at advanced stage and was observed more frequent in elderly patients. Statistically significant association of tumor histological grade with stage and also of patient's age with tumor grade and stage was observed p
A Case Report of Fibrolamellar Hepatocellular Carcinoma in a Young Adult
Authors: Atiq Muhammad , Haroon Muhammad , Khan Muhammad Imran , Ammar Ahmed Siddique , Khalid Warda , Hanif Faisal
Published: September 2022

Among the four histopathological variants of hepatocellular carcinoma, Fibrolamellar hepatocellular carcinoma (FLHCC) is a rare variant of hepatocellular carcinoma (HCC). It occurs in less than 1 % cases of hepatocellular carcinoma with distinct features as compared to classical HCC. It differs from typical HCC in terms of epidemiology, etiology, clinical presentation and prognosis. In this case report we are going to present a case of fibrolamellar variety of HCC in a 20-year young male with no history of previous liver disease and no characteristics features on Computed Tomography (CT) scan when compared with typical HCC. After discussing in multidisciplinary meeting, he underwent non anatomical liver resection which remained uneventful. Histopathology of the biopsy sample revealed FLHCC. No neoadjuvant therapy was given. Patient was kept on 1 year follow-up and no recurrence or metastasis occurred.
The Sehat Ghar: An Innovation to Improve Primary Healthcare in Rural Punjab
Authors: Bhatti Muhammad Ajmal , Asad Azhar Muhammad , Hassan Zohaib , Agha Muhammad Ammar , Fahad Qadir Bukhari Syed , Aftab Wajdan
Published: September 2022

An effective healthcare sector essentially relies on a strong primary healthcare system. The primary healthcare system governs all major aspects of preventive healthcare and family planning services including immunization, hygiene, communicable disease prevention, sanitation, etc. In addition to this, a major bottleneck limiting the quality of healthcare at secondary and tertiary health facilities is the very high patient footfall that these hospitals. The primary healthcare facilities are designed to be the first tier of facility that a patient falls onto, and hence is either treated there or referred to higher level facilities by screening and limiting patient flow to next levels. Supporting this tier hence helps reduce burden on secondary and tertiary facilities of patients that could have been treated at primary facilities and hence exponentially improve the quality of health services in these lager hospitals. The document discusses some of the major issues faced by the primary healthcare sector in Punjab. These issues were studied and analyzed in detail at South Punjab Health Department, which is an arm of the provincial health department governing 11 districts of Southern Punjab – districts where socio-economic conditions are generally much poorer than the rest of Punjab. This document discusses the initiative of Sehat Ghar, its model, potential to ensure basic health services delivery to the local population and its direct & indirect contribution to tackle major issues of primary healthcare in Punjab.
Superstición y fantasía en «Gubi Amaya», de Juana Manuela Gorriti
Authors: Anchante Arias Jim Alexander
Published: September 2022

El presente artículo es un análisis del relato «Gubi Amaya», de la escritora argentina Juana Manuela Gorriti. Dicho análisis se basa en la estructuración externa del relato, así como en la configuración de su mundo representado, vinculado con el contexto de la literatura gótica y el romanticismo. A partir de dicho vínculo, se busca demostrar que el relato en cuestión se identifica con una tendencia fantástica a partir de la categoría de superstición. El marco teórico empleado destaca la caracterización de lo fantástico como estrategia para la revelación del pensamiento supersticioso. Así, un elemento clave para entender esta propuesta estético-ideológica es la recuperación del mundo perdido de la infancia por parte de la narradora. Dicha recuperación, y el efecto fantástico que ello conlleva, se logra a través de un viaje espacio-temporal como posible llave del enigma en el relato. Ahora bien, se expresa a su vez un desdoblamiento del personaje que da título al texto, lo que conduce a la noción del doble como prototipo de la literatura fantástica. Para esclarecer este fenómeno paranormal, se emplea el concepto freudiano de lo siniestro, a partir de lo cual se busca aclarar si el accionar de la narradora en su búsqueda del pasado forma parte de la realidad o del mundo del sueño.
Comparative Combinatorial Implications and Theranostics of Immunotherapy in
the Impediment of Alveolar Soft Part Sarcoma
Authors: Fan Ruitai , Yang Ya , Beeraka Narasimha M. , Liu Junqi , Zuo Xiaoxiao , Wang Xin , Li Tingxuan
Published: September 2022

Background:

Immune checkpoint inhibitors (ICIs), specifically programmed cell death receptor-1/ligand 1 (PD-1/L1) inhibitors, have shown potential pharmacological efficacy in several cancers. Nonetheless, data pertinent to their therapeutic efficacy in alveolar soft-part sarcoma (ASPS) are limited.

Objective:

The retrospective aspects of ICIs (anti-PD1/PD-L1 blockers) to target ASPS comparatively analyzed for clinical outcomes with other targeted immunotherapy modalities.

Methods:

We have conducted a systematic review without statistical analysis or comprehensive meta-analysis by collecting the articles published between 1952 and Sep 10th, 2020 by searching the following words: alveolar soft part sarcoma and immunotherapy including immune checkpoint, immune checkpoint inhibitors, and PD-1, PD-L1. We performed a pooled analysis of case reports, conferences, clinical trials, and other research reports pertinent to the efficacy of a PD-1 or PD-L1 antagonist in patients diagnosed with metastatic ASPS.

Results:

The effective studies include 10 case reports, 2 conference reports, 5 clinical trials, and 2 additional research reports. Total 110 patients were reported to be enrolled in the pooled analysis; among them, 87 (78.38%) received a PD-1/PD-L1 antagonist. Patients who received anti-PD-1/PD-L1as monotherapy, then their clinical response rates (CRR) were 63.22% whereas the patients who received targeted therapy and immunotherapy, their CRR was 78.95% (15/19). The patients treated with double immunotherapy, their CRR was 100% (4/4). Tumor mutational burden and mismatch repair status have significant implications to predict the prognosis of ASPS.

Conclusion:

Alveolar soft-part sarcoma patients with distant metastases can exhibit better clinical outcomes with immunotherapy, particularly toripalimab, atezolizumab, and axitinib combinatorial regimen with pembrolizumab. In addition, this review describes the therapeutic implications to guide personalized medicine depending on the expression patterns of PD-1/PD-L1 during the immunotherapy with ASPS.
Involvement of Metabolites and Non-coding RNAs in Diseases
Authors: Coskun Kubra A. , Kıyak Bercem Yeman , Cifci Kezban Ucar , Kadioglu Elif , Yurekli Nazlican , Tutar Yusuf
Published: September 2022

Non-coding RNAs have a role in gene regulation and cellular metabolism control. Metabolism
produces metabolites which are small molecules formed during the metabolic process. So
far, a direct relationship between metabolites and genes is not fully established; however, pseudogenes
and their progenitor genes regulate health and disease states. Other non-coding RNAs also
contribute to this regulation at different cellular processes. Accumulation and depletion of metabolites
accompany the dynamic equilibrium of health and disease state. In this study, metabolites, their
roles in the cell, and the link between metabolites and non-coding RNAs are discussed.
Bidirectional Relations Between Anxiety, Depression, and Cancer: A Review
Authors: Montazersaheb Soheila , Soofiyani Saiedeh Razi , Nakhlband Ailar , Farahzadi Raheleh , Saeedi Nazli , Barzegar Habibeh
Published: September 2022

Epidemiological evidence continues to accumulate on the effect of stress and depression on cancer initiation and progression. Depression has been introduced as an independent predictor of increased cancer mortality. At the same time, early intervention for depression increases the surviv-al rate. Even some evidence has given prognostic value for depression to predict cancer recurrence and mortality. This article presents current evidence on the correlations of molecular mechanisms of cancer and depression through; I. The evidence shows the role of pre-existing depression and anxie-ty in the development and progression of cancer. II. The Immune system performs a crucial role in stress, depression, and cancer. III. The role of stress and depression-induced inflammation. IV. The evidence has proposed that cancer may result in depression and the effect of depression on cancer outcomes. In conclusion, the importance of preventive interventions to monitor patients’ mental health during cancer treatment is very significant and should not be underestimated. In other words, the initial interventions can improve depressive symptoms and increase cancer survival. On the oth-er hand, by identifying key biomarkers of depression, physicians can identify cancer patients at risk for depression or those who may not respond to routine treatments. Revealing the molecular mecha-nism of the cancer microenvironment in the development of comorbidities promises innovative therapeutic options for cancer. Identifying these mechanisms opens a new avenue in identifying cancer patients at risk for depression and can also provide considerable potential in identifying de-pressive patients prone to cancer.
Familial Hypercholesterolaemia in Children and Adolescents: Current and
Future Perspectives
Authors: Bassareo Pier Paolo , Martino Francesco , Barilla Francesco , Martino Eliana , Calcaterra Giuseppe , Fanos Vassilios
Published: September 2022

Familial hypercholesterolemia (FH) is a genetic disease, the underlying cause of which is represented by mutations capable of influencing the metabolism of low-density lipoproteins (LDL). The distinguishing characteristic of FH is increased LDL cholesterol blood levels since birth which trigger early development of atherosclerosis-related diseases. Diagnosis of FH is frequently either missed or made with a considerable delay. Prompt identification of the disease is pivotal in implementing early prevention measures. Safe and effective drugs have been approved for use in children and adolescents, with statins, with or without ezetimibe, representing first-line therapy. At times, however, these medications may not be sufficient to achieve the therapeutic target, particularly in homozygous FH patients. In such cases, lipoprotein apheresis, which has proved to be safe and efficient, is strongly suggested. New drugs still at the investigational stage may represent a promising and personalised therapy. The lowering of cholesterol levels in childhood hampers the formation of arterial atherosclerotic plaques, thus reducing cardiovascular events later in life. Accordingly, early detection, diagnosis, and therapy in FH subjects are priority aims.
Rodent Gingival Tissue Culture in an Aging Experimental Model: A Pilot Study
Authors: Mutiara Arrum , Sulijaya Benso , Masulili Sri Lelyati C. , Bachtiar Boy M. , Sumbayak Ines A. , Tadjoedin Fatimah Maria , Wati Permana , Kartika Devi
Published: September 2022

Background:

Gingiva acts as a barrier to prevent further invasion of pathogens in periodontitis. The gingival structure consists of epithelial tissue and connective tissue. As the aging process continues, there are several changes in the periodontium. Previous studies have tried to investigate the complex interaction between the host immune system and bacteria by using animal models, especially rodents.

Objective:

The aim of the study was to evaluate the effectiveness of collecting gingival tissue from the palate and retromolar pad.

Materials and Methods:

The aging experimental model had two age categories of male rodents of 18 and 58 weeks. Tissue was collected from the mandible retromolar pad and palate with full-thickness excision. Tissues were transferred to a complete medium at 4°C. Gingival tissue was cultured in a 37°C culture incubator at 5% CO2. Tissue proliferation was observed on the first, third, and fifth days using the hemocytometer. The cell metabolism rate between the two age categories was checked using the MTT Assay. Two-way ANOVA was used for statistical analysis.

Results:

Gingival tissues obtained from the experimental models of two age categories were alive, and proliferation was observed. The old rodent group showed no significant result in terms of cell morphology on the first vs. third day (p>0.05), but significant results were found on the first vs. fifth day and third day vs. the fifth day (p<0.05). The young rodent group showed the most significant morphology changes between days. In both young and old categories, no significant difference was observed in the cell metabolism.

Conclusion:

Rodent gingival tissue collection from the retromolar pad and palate was found suitable for tissue culture in the aging experimental study.
Justice and Guanxi in Hiring: Fairness Reactions of US and Chinese Students
Authors: Lilly Juliana D. , Virick Meghna , Simmons Aneika L. , Liao Weiwen
Published: September 2022

This study investigated cross-cultural perceptions of justice between U.S. and Chinese students. The experimental design included four allocation rules (equity, equality, need, and guanxi) along with conditions of hired/not hired and most qualified/least qualified. Hofstede’s cultural dimensions and organizational justice are used for hypothesis development, with procedural and distributive justice as dependent variables. Results show U.S. students perceiving equity as fairer than Chinese students and Chinese students perceiving guanxi as fairer than U.S. students under certain conditions. Surprisingly, U.S. students rated equality and need allocation as more fair than Chinese students in some conditions, contrary to what was hypothesized.
The effect of maritime English vocabulary for beginners module on the vocabulary learning outcomes
Authors: Abduh Mochamad , Hasnur Juliandri , Siska Syafni Yelvi
Published: September 2022

This research started from the problem of the current covid-19 pandemic condition and situation, which makes cadets have to study online and most by themselves. In addition, it is based on the fact that there has been no specific module discussing basic terms or Maritime English vocabulary specifically for each department. The purpose of this study is to reveal whether there is an effect of using the maritime English vocabulary for beginners module on the vocabulary learning outcomes and how effective the use of the module is for cadets of Batch V Nautical Department, Shipping Polytechnic, West Sumatra. This type of research is experimental with the one-group pretest posttest design (pre-experimental design). This research was carried out in all classes of the nautical department Batch V, which consisted of 3 categories; Nautical A, Nautical B, and Nautical C. The sample used purposive sampling in this research, so the writer only took cadets in nautical majors, with a total sample of 60 persons. Based on the results, it was found that there was an effect of using the maritime English vocabulary for beginners module on the learning outcomes of maritime English vocabulary for Nautical Department cadets Batch V. Furthermore, from the results of questionnaire data processing, it can be concluded that the use of maritime English vocabulary for beginners module in maritime English vocabulary learning is effective for Nautical Department cadets Batch V in West Sumatra Merchant Marine Polytechnic in 2021.
Internal factors that are influencing in determining the selction of expertise programs in vocational high school
Authors: Rahdiyanta Dwi , Syauqi Khusni , Arifin Achmad
Published: September 2022

This study aims to examine the effect of students' internal factors (information literacy, self-understanding, and attitude) on their decision to enroll in the mechanical engineering program of vocational high school. It is ex-post facto correlation research using a sample of 300 out of a total of 1,086 students. The sample was established using the proportional random sampling technique by means of the Krejcie and Morgan formula. The data were collected by means of questionnaires, observation sheets, and documents. The findings reveal that (1) There is a significant and positive correlation between the internal factors and the student's decision to enroll in the mechanical engineering program of vocational high school (VHS); and (2) All internal factors have a significant effect on both directly and indirectly on the students' preference for mechanical engineering program of vocational high school (VHS).
Impact and Perceived Value of iGeriCare e-Learning Among Dementia Care Partners and Others: Pilot Evaluation Using the IAM4all Questionnaire
Authors: Scott Andrew F , Ayers Stephanie , Pluye Pierre , Grad Roland , Sztramko Richard , Marr Sharon , Papaioannou Alexandra , Clark Sandra , Gerantonis Patricia , Levinson Anthony J
Published: September 2022

Background

Care partners of people living with dementia may benefit from web-based education. We developed iGeriCare, an award-winning internet-based platform with 12 multimedia e-learning lessons about dementia.

Objective

Our objective was to evaluate users’ perceptions of impact.

Methods

From March 17, 2021 to May 16, 2022, data were collected upon lesson completion. We used the content-validated Information Assessment Method for all (IAM4all) for patients and the public adapted for dementia care partners. The IAM4all questionnaire assesses outcomes of web-based consumer health information. Responses were collected using SurveyMonkey, and data were analyzed using IBM SPSS Statistics (version 28).

Results

A total of 409 responses were collected, with 389 (95.1%) survey respondents completing the survey. Of 409 respondents, 179 (43.8%) identified as a family or friend care partner, 84 (20.5%) identified as an individual concerned they may have mild cognitive impairment or dementia, 380 (92.9%) identified the lesson as relevant or very relevant, and 403 (98.5%) understood the lesson well or very well. Over half of respondents felt they were motivated to learn more, they were taught something new, or they felt validated in what they do, while some felt reassured or felt that the lesson refreshed their memory. Of 409 respondents, 401 (98%) said they would use the information, in particular, to better understand something, discuss the information with someone else, do things differently, or do something.

Conclusions

Users identified iGeriCare as relevant and beneficial and said that they would use the information. To our knowledge, this is the first time the IAM4all questionnaire has been used to assess patient and caregiver feedback on internet-based dementia education resources. A randomized controlled trial to study feasibility and impact on caregiver knowledge, self-efficacy, and burden is in progress.
Review of Hermans, Theo. Translation and History: A Textbook. Routledge, 2022. 162 pp.
Authors: Malena Anne
Published: September 2022

Review
Research and Application of Best Practices for Water Saving in Industry
Authors: M’Baye Abaubakry
Published: September 2022

Water is a crucial resource for the earth and therefore for all living beings on earth such human. This article is focused on how to optimize water usage (saving) in industrial environment. This sector has a huge impact on water: usage, pollution, etc. The first step was to define and apply a water management and the second step to make research on each opportunity identified and to implement it. All those actions have been carried out in a pharmaceutical manufacturing site. Water saving have been done on different application: washing machine, heat pump on chiller system, osmosis inverses system on purified water and continuous measurement device of water quality. The site’s water consumption has been reduced by 40% in less than 6 years.
Affirmative actions for people inserted in the socio-territorial space of the countryside in the Bachelor's Degree in Agroecology at UFRPE
Authors: Gois Pamela Karina de Melo , Alves Ângelo Giuseppe Chaves , Lira Wagner Lins
Published: September 2022

Affirmative action policies for access to higher education in Brazil has been, in recent decades, a theme widely discussed by the agendas of social movements, because the struggle for the democratization of access to Higher Education, linked to the perspective of social justice, demands actions and policies aimed at minorities historically excluded from society and, as a result, higher education levels. Therefore, this article aims to describe and analyze the affirmative action policy - which guarantees the access and permanence of people inserted in the socioterritorial space of the field - directed to the Bachelor's Degree in Agroecology at UFRPE. For this, we developed a case study anchored in the historical-organizational perspective, based empirically on documentary research. The results reveal that, of the 40 annual vacancies offered by the Course, most of it is reserved for rural students and that, as much as it is a recent affirmative action, starting in 2019, this is promising in the inclusion of peasant subjects in higher education, in a context beyond insertion, but for interdisciplinary, joint and participatory construction from theory and practice, respecting the knowledge-making of the rural environment and committed to peasant experiences.
Reflexiones sobre el Centro de Innovación del Ministerio de Educación de Chile
Authors: Marambio Sebastián
Published: September 2022

En este video, Sebastián Marambio presenta reflexiones derivadas de su trabajo en el Centro de Innovación del Ministerio de Chile relacionadas con las oportunidades para innovar, los tiempos fuera de la escuela en que se puede enriquecer el aprendizaje y el aprovechamiento de la tecnología en la educación.
Centro de Talentos de la Universidad Virtual del Estado de Guanajuato
Authors: Nieto Rangel Ana Edith , Sánchez Lemus Luis Francisco
Published: September 2022

La Universidad Virtual del Estado de Guanajuato (UVEG) creó el Centro de Talentos como una estrategia para la promoción y desarrollo de las habilidades blandas, mediante una plataforma educativa en modalidad virtual. Este proyecto se constituye para contribuir al desarrollo académico y profesionalización del estudiantado, egresados y personas inmersas en el mercado laboral. El Centro surgió en 2020 gracias a una colaboración interdisciplinaria entre académicos, directivos y consultores externos, proporcionando así la oferta de un programa flexible e innovador que responde a las necesidades del entorno.
Coursera como apoyo al nivel medio superior
Authors: Kikushima Juan
Published: September 2022

El artículo presenta el origen y desarrollo de Coursera como proveedor de cursos abiertos masivos en línea (MOOC) y su uso dentro del nivel medio superior. Se destaca la utilidad de estos cursos sin costo tanto para estudiantes (apoyo para el aprendizaje en sus asignaturas, opción de orientación vocacional) como para docentes (para enriquecer su práctica). Adicionalmente, se abordan las posibilidades que la plataforma ofrece para validar habilidades que el mercado laboral solicita en la actualidad y para explorar áreas de desarrollo en el cambiante contexto del trabajo.
El fin de la constitución autoritaria de Pinochet
Authors: Cárdenas Gracia Jaime
Published: September 2022

En este ensayo damos cuenta de la Convención Constitucional Chilena en curso que pondrá fin a la Constitución neoliberal y autoritaria de Pinochet. Sostenemos que el diseño institucional de 1980 y sus reformas de 1989 y 2005 prohijaron movimientos sociales que desembocaron en el proceso constituyente que vive el país sudamericano porque esa estructura jurídica formuló y materializó los fundamentos del neoliberalismo y del autoritarismo. Consideramos que cuando las Constituciones se conciben desde parámetros de desigualdad social y de reducción del pluralismo político, las derivas concluyen en procesos constituyentes originarios para transformar el statu quo.