bluuebunny/crossref_metadata_2025 huggingface dataset:
Special Issue: Landscape Urbanism and Green Infrastructure
Authors: Panagopoulos Thomas
Published: July 2019

With the notion of landscape urbanism long neglected, interlinkages between ecology and architecture in the built environment are becoming visible. Yet, the diversity in understandings of the interconnections between cities and nature is the starting point for our research interest. This volume contains nine thoroughly refereed contributions concerning a wide range of topics in landscape architecture and urban green infrastructure. While some papers attempt to conceptualize the relation further, others clearly have an empirical focus. Thereby, this special issue provides a rich body of work, and will act as a starting point for further studies on biophilic urbanism and integrative policies, such as the sustainable development goals of the United Nations.
Effects of a Short Heat Treatment Period on the Pullout Resistance of Shape Memory Alloy Fibers in Mortar
Authors: Kim Min Kyoung , Kim Dong Joo , Chung Young-Soo , Choi Eunsoo
Published: July 2019

The feasibility of the crack closure of cementitious composites reinforced with shape memory alloy (SMA) fibers was investigated by performing single-fiber pullout tests. To demonstrate the fast crack closing ability, in this study, a heat treatment (300 °C) was applied for a short time (10 min). A short heat treatment was applied for 10 min, after the slip reached 0.5 mm, to activate the shape memory effects of cold-drawn SMA fibers. Two types of alloys were investigated, NiTi and NiTiNb, with two geometries, either smooth or dog-bone-shaped. During the heat treatment, the pullout stress of the SMA fibers initially decreased due to thermal extension, and then increased after heating for 1–3 min, resulting from the shape memory effects. However, their pullout stress recovery during and after the heat treatment was different for the different alloys and fiber geometries. The NiTi fibers generally produced a higher and faster recovery in terms of their pullout stress than the NiTiNb fibers, while the dog-bone-shaped fibers showed a faster pullout stress recovery than the smooth fibers.
Tomographic Collection of Block-Based Sparse STEM Images: Practical Implementation and Impact on the Quality of the 3D Reconstructed Volume
Authors: Trépout Sylvain
Published: July 2019

The reduction of the electron dose in electron tomography of biological samples is of high significance to diminish radiation damages. Simulations have shown that sparse data collection can perform efficient electron dose reduction. Frameworks based on compressive-sensing or inpainting algorithms have been proposed to accurately reconstruct missing information in sparse data. The present work proposes a practical implementation to perform tomographic collection of block-based sparse images in scanning transmission electron microscopy. The method has been applied on sections of chemically-fixed and resin-embedded Trypanosoma brucei cells. There are 3D reconstructions obtained from various amounts of downsampling, which are compared and eventually the limits of electron dose reduction using this method are explored.
Process-Structure-Property Relationships of AISI H13 Tool Steel Processed with Selective Laser Melting
Authors: Narvan Morteza , Al-Rubaie Kassim S. , Elbestawi Mohamed
Published: July 2019

Due to a good combination of high hardness, wear resistance, toughness, resistance to high operating temperatures, and fairly low material cost, AISI H13 tool steel is commonly used in the manufacture of injection molds. Additive manufacturing (AM) such as selective laser melting (SLM), due to the layer-wise nature of the process, offers substantial geometric design freedom in comparison with conventional subtractive manufacturing methods, thereby enabling a construction of complex near-net shape parts with internal cavities like conformal cooling channels. The quality of SLM-manufactured parts mainly depends on the part geometry, build orientation and scanning strategy, and processing parameters. In this study, samples of H13 tool steel with a size of 10 × 10 × 15 mm3 were SLM-manufactured using a laser power of 100, 200, and 300 W; scanning speed of 200, 400, 600, 800, 1000, and 1200 mm/s; and hatch spacing of 80 and 120 µm. A constant layer thickness of 40 µm, 67° scanning rotation between subsequent layers, and a stripe scanning strategy were maintained during the process. The samples were built considering a preheating of 200 °C. The relative density, surface roughness, crack formation, microstructure, and hardness were evaluated. The relative density is shown to increase with increasing the volumetric energy density up to a value of about 60 J/mm3 and then no significant increase can be pointed out; the maximum relative density of 99.7% was obtained. A preheating of 200 °C generally aids to increase the relative density and eliminate the crack formation. The microstructure of built samples shows fine equiaxed cellular-dendritic structure with martensite and some retained austenite. The microhardness of the as-built samples was found to vary from 650 to 689 HV 0.2, which is comparable to a conventionally produced H13 tool steel.
HEMA Effects on Autophagy Mechanism in Human Dental Pulp Stem Cells
Authors: Diomede Francesca , Tripodi Domenico , Trubiani Oriana , Pizzicannella Jacopo
Published: July 2019

Autophagy is a complex mechanism that permits the degradation of cellular components in order to enhance cell homeostasis, recycling the damaged, dysfunctional, or unnecessary components. In restorative dentistry practice, free resin monomers of 2-hydroxyethyl methacrylate (HEMA) can be released. The aim of this study was to investigate the effect of HEMA on proliferation and autophagy in human dental pulp stem cells (hDPSCs). Human DPSCs were treated with different concentrations of HEMA (3 and 5 mmol L−1). To evaluate the proliferation rate, MTT and trypan blue assays were used. Autophagic markers such as microtubule-associated protein 1 light chain 3 (LC3-I/II) and ubiquitin-binding protein (p62) were analyzed through immunofluorescence observations. Beclin1, LC3-I/II, and p62 were evaluated by means of Western blotting detection. Considering that activity of extracellular signal–regulated kinase (ERK) and its phosphorylated form (pERK) mediates several cellular processes, such as apoptosis, autophagy, and senescence, the involvement of ERK/pERK signaling was also evaluated. Obtained results showed a decreased cell proliferation associated with morphological changes in HEMA-treated cells. The Western blot results showed that the expression levels of Beclin1, LC3-I/II, and ERK were significantly elevated in HEMA-treated cells and in cells co-treated with rapamycin, an autophagic promoter. The expression levels of p62 were significantly reduced compared to the untreated samples. Protein levels to the autophagic process, observed at confocal microscopy confirmed the data obtained from the Western blot. The up-regulation of ERK and pERK levels, associated with nuclear translocation, revealed that ERK pathway signaling could act as a promoter of autophagy in dental pulp stem cells treated with HEMA.
On q-Hermite-Hadamard Inequalities for Differentiable Convex Functions
Authors: Jhanthanam Seksan , Tariboon Jessada , Ntouyas Sotiris K. , Nonlaopon Kamsing
Published: July 2019

In this paper, we establish some new results on the left-hand side of the q-Hermite–Hadamard inequality for differentiable convex functions with a critical point. Our work extends the results of Alp et. al (q-Hermite Hadamard inequalities and quantum estimates for midpoint type inequalities via convex and quasi-convex functions, J. King Saud Univ. Sci., 2018, 30, 193-203), by considering the critical point-type inequalities.
Impact of Depression in Sickle Cell Disease Hospitalization-Related Outcomes: An Analysis of the National Inpatient Sample (NIS)
Authors: Onyeaka Henry K. , Queeneth Uwandu , Rashid Wahida , Ahmad Naveed , Kuduva Rajan Shanthini , Jaladi Paul Rahul , Patel Rikinkumar S.
Published: July 2019

Background and objectives: This study aimed to analyze and discern the differences in demographics and inpatient outcomes (length of stay (LOS), total charges, disease severity, and mortality) between depressed versus non-depressed sickle cell disease (SCD) patients. Materials and Methods: A retrospective analysis was conducted using the Nationwide Inpatient Sample (2010–2014). We identified 73,225 SCD hospitalizations and comorbid depression (6317, 8.6%) as the primary and the other diagnosis, respectively, using International Classification of Diseases (ICD)-9 codes. We used linear and logistic regression model to evaluate the changes in inpatient outcomes. Results: Comorbid depression was more prevalent among middle-aged adults (11.5%), females (10.63%), and whites (12.43%). We did not find any association between income and comorbid depression among SCD patients. After adjusting for the demographic covariates, comorbid depression remained a significant risk factor for longer LOS (mean difference −1.16 days, 95% CI −1.30 to −1.03) and higher total charges (mean difference −USD5058, 95% CI −6261 to −3855) during hospitalization. SCD with comorbid depression was also significantly associated with a higher number of chronic conditions (mean difference −2.08, 95% CI −2.13 to −2.03) and 1.5 times (95% CI 1.39 to 1.63) higher odds of major severity of illness. Conclusion: Comorbid depression was significantly associated with longer LOS, more severity of illness, and higher hospital charges. Healthcare providers caring for adults with SCD should consider screening for and treating comorbid depression to improve the health-related quality of life.
Elastic Parameters of Paramagnetic Fe–20Cr–20Ni-Based Alloys: A First-Principles Study
Authors: Al-Zoubi Noura
Published: July 2019

The single-crystal and polycrystalline elastic parameters of paramagnetic Fe0.6−xCr0.2Ni0.2Mx (M = Al, Co, Cu, Mo, Nb, Ti, V, and W; 0 ≤ x ≤ 0.08) alloys in the face-centered cubic (fcc) phase were derived by first-principles electronic structure calculations using the exact muffin-tin orbitals method. The disordered local magnetic moment approach was used to model the paramagnetic phase. The theoretical elastic parameters of the present Fe–Cr–Ni-based random alloys agree with the available experimental data. In general, we found that all alloying elements have a significant effect on the elastic properties of Fe–Cr–Ni alloy, and the most significant effect was found for Co. A correlation between the tetragonal shear elastic constant C′ and the structural energy difference ΔE between fcc and bcc lattices was demonstrated. For all alloys, small changes in the Poisson’s ratio were obtained. We investigated the brittle/ductile transitions formulated by the Pugh ratio. We demonstrate that Al, Cu, Mo, Nb, Ti, V, and W dopants enhance the ductility of the Fe–Cr–Ni system, while Co reduces it. The present theoretical data can be used as a starting point for modeling the mechanical properties of austenitic stainless steels at low temperatures.
MolNetEnhancer: Enhanced Molecular Networks by Integrating Metabolome Mining and Annotation Tools
Authors: Ernst Madeleine , Kang Kyo Bin , Caraballo-Rodríguez Andrés Mauricio , Nothias Louis-Felix , Wandy Joe , Chen Christopher , Wang Mingxun , Rogers Simon , Medema Marnix H. , Dorrestein Pieter C. , van der Hooft Justin J.J.
Published: July 2019

Metabolomics has started to embrace computational approaches for chemical interpretation of large data sets. Yet, metabolite annotation remains a key challenge. Recently, molecular networking and MS2LDA emerged as molecular mining tools that find molecular families and substructures in mass spectrometry fragmentation data. Moreover, in silico annotation tools obtain and rank candidate molecules for fragmentation spectra. Ideally, all structural information obtained and inferred from these computational tools could be combined to increase the resulting chemical insight one can obtain from a data set. However, integration is currently hampered as each tool has its own output format and efficient matching of data across these tools is lacking. Here, we introduce MolNetEnhancer, a workflow that combines the outputs from molecular networking, MS2LDA, in silico annotation tools (such as Network Annotation Propagation or DEREPLICATOR), and the automated chemical classification through ClassyFire to provide a more comprehensive chemical overview of metabolomics data whilst at the same time illuminating structural details for each fragmentation spectrum. We present examples from four plant and bacterial case studies and show how MolNetEnhancer enables the chemical annotation, visualization, and discovery of the subtle substructural diversity within molecular families. We conclude that MolNetEnhancer is a useful tool that greatly assists the metabolomics researcher in deciphering the metabolome through combination of multiple independent in silico pipelines.
Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS)
Authors: Playdon Mary C. , Joshi Amit D. , Tabung Fred K. , Cheng Susan , Henglin Mir , Kim Andy , Lin Tengda , van Roekel Eline H. , Huang Jiaqi , Krumsiek Jan , Wang Ying , Mathé Ewy , Temprosa Marinella , Moore Steven , Chawes Bo , Eliassen A. Heather , Gsur Andrea , Gunter Marc J. , Harada Sei , Langenberg Claudia , Oresic Matej , Perng Wei , Seow Wei Jie , Zeleznik Oana A.
Published: July 2019

The application of metabolomics technology to epidemiological studies is emerging as a new approach to elucidate disease etiology and for biomarker discovery. However, analysis of metabolomics data is complex and there is an urgent need for the standardization of analysis workflow and reporting of study findings. To inform the development of such guidelines, we conducted a survey of 47 cohort representatives from the Consortium of Metabolomics Studies (COMETS) to gain insights into the current strategies and procedures used for analyzing metabolomics data in epidemiological studies worldwide. The results indicated a variety of applied analytical strategies, from biospecimen and data pre-processing and quality control to statistical analysis and reporting of study findings. These strategies included methods commonly used within the metabolomics community and applied in epidemiological research, as well as novel approaches to pre-processing pipelines and data analysis. To help with these discrepancies, we propose use of open-source initiatives such as the online web-based tool COMETS Analytics, which includes helpful tools to guide analytical workflow and the standardized reporting of findings from metabolomics analyses within epidemiological studies. Ultimately, this will improve the quality of statistical analyses, research findings, and study reproducibility.
Fabrication of Microwave Devices Based on Magnetic Nanowires Using a Laser-Assisted Process
Authors: Van Kerckhoven Vivien , Piraux Luc , Huynen Isabelle
Published: July 2019

This paper compares two laser-assisted processes developed by the authors for the fabrication of microwave devices based on nanowire arrays loaded inside porous alumina templates. Pros and cons of each process are discussed in terms of accuracy, reproducibility and ease of fabrication. A comparison with lithography technique is also provided. The efficiency of the laser-assisted process is demonstrated through the realization of substrate integrated waveguide (SIW) based devices. A Nanowired SIW line is firstly presented. It operates between 8.5 and 17 GHz, corresponding to the first and second cut-off frequency of the waveguide, respectively. Next, a Nanowired SIW isolator is demonstrated. It shows a nonreciprocal isolation of 12 dB (corresponding to 4.4 dB/cm), observed in absence of a DC magnetic field, and achieved through an adequate positioning of ferromagnetic nanowires inside the waveguide cavity.
Analysis on Machining Performance of Nickel-Base Superalloy by Electrochemical Micro-milling with High-Speed Spiral Electrode
Authors: Liu Yong , Xu Xiaodong , Guo Chunsheng , Kong Huanghai
Published: July 2019

As one of the most promising micro-machining methods, electrochemical micro-machining is widely used in the field of metal micro-structures. The electrochemical micro-milling on Nickel-base superalloy by using high-speed spiral electrode was studied in detail. Firstly, the electric field and flow field models of micro-electrochemical milling are established and analyzed by the finite element method. Then, the milling profile was predicted and the effect of high-speed rotation of electrodes on electrolyte promotion and secondary electrolysis prevention were analyzed. Secondly, the influence of the main machining parameters, such as rotating speed, electrical parameters, and feed rate on machining precision and efficiency was analyzed experimentally. Finally, by optimizing the machining parameters, a series of micro-graphic structures with a width of about 150 μm were obtained on Nickel-base superalloy 718 by using the spiral electrode with a diameter of 100 μm. The experimental and simulation results show that the high-speed rotation of electrodes can greatly improve the machining efficiency and stability. It was proved that micro-electrochemical milling with the high-speed rotating electrode technique is an effective method for machining micro-metal parts.
The Applications of 3D Printing for Craniofacial Tissue Engineering
Authors: Tao Owen , Kort-Mascort Jacqueline , Lin Yi , Pham Hieu , Charbonneau André , ElKashty Osama , Kinsella Joseph , Tran Simon
Published: July 2019

Three-dimensional (3D) printing is an emerging technology in the field of dentistry. It uses a layer-by-layer manufacturing technique to create scaffolds that can be used for dental tissue engineering applications. While several 3D printing methodologies exist, such as selective laser sintering or fused deposition modeling, this paper will review the applications of 3D printing for craniofacial tissue engineering; in particular for the periodontal complex, dental pulp, alveolar bone, and cartilage. For the periodontal complex, a 3D printed scaffold was attempted to treat a periodontal defect; for dental pulp, hydrogels were created that can support an odontoblastic cell line; for bone and cartilage, a polycaprolactone scaffold with microspheres induced the formation of multiphase fibrocartilaginous tissues. While the current research highlights the development and potential of 3D printing, more research is required to fully understand this technology and for its incorporation into the dental field.
Morphology of Detrital Zircon as a Fingerprint to Trace Sediment Provenance: Case Study of the Yangtze Delta
Authors: Yue Wei , Yue Xiyuan , Zhang Lingmin , Liu Xianbin , Song Jian
Published: July 2019

Deltaic areas and marginal seas are important archives that document information on regional tectonic movement, sea level rise, river evolution, and climate change. Here, sediment samples from boreholes of the Yangtze Delta and the modern Yangtze drainage were collected. A quantitative analysis of detrital zircon morphology was used to discuss the provenance evolution of the Yangtze Delta. This research demonstrated that a dramatic change in sediment provenance occurred in the transition from the Pliocene to Quaternary. Zircon grains in the Pliocene sediments featured euhedral crystals with large elongation (>3 accounted for 13.2%) and were closely matched to tributary samples in the Lower Yangtze (>3 accounted for 11.3%), suggesting sediment provenance from the proximal river basin. However, most detrital zircon grains of the Quaternary samples exhibited lower values of elongation and increased roundness (rounded grains were 9.4%), which was similar to those found in the modern Yangtze mainstream (rounded grains were 12.5%) and the middle tributaries (rounded grains were 7.0%). The decrease in zircon elongation and improvement of its roundness in the Quaternary strata implied that the Yangtze Delta received sediments of different provenance that originated from the Middle-Upper Yangtze basin due to the uplift of the Tibetan Plateau. Statistical analysis of detrital zircon morphology has proven useful for studying the source-to-sink of sediments.
Hydrogenetic, Diagenetic and Hydrothermal Processes Forming Ferromanganese Crusts in the Canary Island Seamounts and Their Influence in the Metal Recovery Rate with Hydrometallurgical Methods
Authors: Marino Egidio , González Francisco Javier , Kuhn Thomas , Madureira Pedro , Wegorzewski Anna V. , Mirao Jose , Medialdea Teresa , Oeser Martin , Miguel Catarina , Reyes Jesús , Somoza Luis , Lunar Rosario
Published: July 2019

Four pure hydrogenetic, mixed hydrogenetic-diagenetic and hydrogenetic-hydrothermal Fe-Mn Crusts from the Canary Islands Seamount Province have been studied by Micro X-Ray Diffraction, Raman and Fourier-transform infrared spectroscopy together with high resolution Electron Probe Micro Analyzer and Laser Ablation Inductively Coupled Plasma Mass Spectrometry in order to find the correlation of mineralogy and geochemistry with the three genetic processes and their influence in the metal recovery rate using an hydrometallurgical method. The main mineralogy and geochemistry affect the contents of the different critical metals, diagenetic influenced crusts show high Ni and Cu (up to 6 and 2 wt. %, respectively) (and less Co and REY) enriched in very bright laminae. Hydrogenetic crusts on the contrary show High Co and REY (up to 1 and 0.5 wt. %) with also high contents of Ni, Mo and V (average 2500, 600 and 1300 μg/g). Finally, the hydrothermal microlayers from crust 107-11H show their enrichment in Fe (up to 50 wt. %) and depletion in almost all the critical elements. One hydrometallurgical method has been used in Canary Islands Seamount Province crusts in order to quantify the recovery rate of valuable elements in all the studied crusts except the 107-11H, whose hydrothermal critical metals’ poor lamina were too thin to separate from the whole crust. Digestion treatment with hydrochloric acid and ethanol show a high recovery rate for Mn (between 75% and 81%) with respect to Fe (49% to 58%). The total recovery rate on valuable elements (Co, Ni, Cu, V, Mo and rare earth elements plus yttrium (REY)) for the studied crusts range between 67 and 92% with the best results for Co, Ni and V (up to 80%). The genetic process and the associated mineralogy seem to influence the recovery rate. Mixed diagenetic/hydrogenetic crust show the lower recovery rate for Mn (75%) and Ni (52.5%) both enriched in diagenetic minerals (respectively up to 40 wt. % and up to 6 wt. %). On the other hand, the presence of high contents of undigested Fe minerals (i.e., Mn-feroxyhyte) in hydrogenetic crusts give back low recovery rate for Co (63%) and Mo (42%). Finally, REY as by-product elements, are enriched in the hydrometallurgical solution with a recovery rate of 70–90% for all the studied crusts.
Low-Cost Localized Surface Plasmon Resonance Biosensing Platform with a Response Enhancement for Protein Detection
Authors: Liu Yun , Zhang Ning , Li Ping , Yu Li , Chen Shimeng , Zhang Yang , Jing Zhenguo , Peng Wei
Published: July 2019

There are many potential applications for biosensors that can provide real-time analysis, such as environmental monitoring and disease prevention. In this study, we investigated a simple strategy for real-time protein detection, which had the advantages of affordability, fast response, portability, and ease of use. A robust quantification of protein interaction was achieved by combining capillary localized surface plasmon resonance (LSPR) sensors and complementary metal–oxide–semiconductor (CMOS) image sensors. Gold nanoparticles were modified on the inner wall of the capillary, which was used as a microfluidic channel and sensing surface. We functionalized one of the LSPR sensors using ligand bound to gold nanoparticle. Our proposed biosensing platform could be easily multiplexed to achieve high throughput screening of biomolecular interactions, and it has the potential for use in disposable sensors. Moreover, the sensing signal was enhanced by the extinction effect of gold nanoparticles. The experimental results showed that our device could achieve qualitative identification and quantitative measurement of transferrin and immunoglobulin G (IgG). As a field-portable and low-cost optical platform, the proposed LSPR biosensing device is broadly applicable to various protein binding tests via a similar self-assembly of organic ultrathin films.
Synthesis of Porous Organic Polymers with Tunable Amine Loadings for CO2 Capture: Balanced Physisorption and Chemisorption
Authors: Kong Xueying , Li Shangsiying , Strømme Maria , Xu Chao
Published: July 2019

The cross-coupling reaction of 1,3,5-triethynylbenzene with terephthaloyl chloride gives a novel ynone-linked porous organic polymer. Tethering alkyl amine species on the polymer induces chemisorption of CO2 as revealed by the studies of ex situ infrared spectroscopy. By tuning the amine loading content on the polymer, relatively high CO2 adsorption capacities, high CO2-over-N2 selectivity, and moderate isosteric heat (Qst) of adsorption of CO2 can be achieved. Such amine-modified polymers with balanced physisorption and chemisorption of CO2 are ideal sorbents for post-combustion capture of CO2 offering both high separation and high energy efficiencies.
Facile Synthesis of Well-Dispersed Ni2P on N-Doped Nanomesh Carbon Matrix as a High-Efficiency Electrocatalyst for Alkaline Hydrogen Evolution Reaction
Authors: Yang Fan , Huang Shuo , Zhang Bing , Hou Liqiang , Ding Yi , Bao Weijie , Xu Chunming , Yang Wang , Li Yongfeng
Published: July 2019

The development of non-noble metal hydrogen evolution catalysts that can replace Pt is crucial for efficient hydrogen production. Herein, we develop a type of well-dispersed Ni2P on N-doped nanomesh carbon (NC) electrocatalyst by a facile pyrolysis method, which shows excellent hydrogen evolution reaction (HER) catalytic performance. It is rather remarkable that the overpotential of Ni2P/NC prepared under optimal proportion is 108 mV at 10 mA·cm−2 current density in 1 M KOH solution with the tafel slope of 67.3 mV·dec−1, the catalytic activity has no significant attenuation after 1000 cycles of cyclic voltammetry (CV)method. The hydrogen evolution performance of the electrocatalytic is better than most similar catalysts in alkaline media. The unique mesh structure of the carbon component in the catalyst facilitates the exposure of the active site and reduces the impedance, which improves the efficiency of electron transport as well as ensuring the stability of the hydrogen evolution reaction. In addition, we prove that nitrogen doping and pore structure are also important factors affecting catalytic activity by control experiments. Our results show that N-doped nanomesh carbon, as an efficient support, combined with Ni2P nanoparticles is of great significance for the development of efficient hydrogen evolution electrodes.
Manifestation of the Purcell Effect in Current Transport through a Dot–Cavity–QED System
Authors: Abdullah Nzar Rauf , Tang Chi-Shung , Manolescu Andrei , Gudmundsson Vidar
Published: July 2019

We study the transport properties of a wire-dot system coupled to a cavity and a photon reservoir. The system is considered to be microstructured from a two-dimensional electron gas in a GaAs heterostructure. The 3D photon cavity is active in the far-infrared or the terahertz regime. Tuning the photon energy, Rabi-resonant states emerge and in turn resonant current peaks are observed. We demonstrate the effects of the cavity–photon reservoir coupling, the mean photon number in the reservoir, the electron–photon coupling and the photon polarization on the intraband transitions occurring between the Rabi-resonant states, and on the corresponding resonant current peaks. The Rabi-splitting can be controlled by the photon polarization and the electron–photon coupling strength. In the selected range of the parameters, the electron–photon coupling and the cavity-environment coupling strengths, we observe the results of the Purcell effect enhancing the current peaks through the cavity by increasing the cavity–reservoir coupling, while they decrease with increasing electron–photon coupling. In addition, the resonant current peaks are also sensitive to the mean number of photons in the reservoir.
Influence of Environmental Conditions on the Fusion of Cationic Liposomes with Living Mammalian Cells
Authors: Kolašinac Rejhana , Jaksch Sebastian , Dreissen Georg , Braeutigam Andrea , Merkel Rudolf , Csiszár Agnes
Published: July 2019

Lipid-based nanoparticles, also called vesicles or liposomes, can be used as carriers for drugs or many types of biological macromolecules, including DNA and proteins. Efficiency and speed of cargo delivery are especially high for carrier vesicles that fuse with the cellular plasma membrane. This occurs for lipid mixture containing equal amounts of the cationic lipid DOTAP and a neutral lipid with an additional few percents of an aromatic substance. The fusion ability of such particles depends on lipid composition with phosphoethanolamine (PE) lipids favoring fusion and phosphatidyl-choline (PC) lipids endocytosis. Here, we examined the effects of temperature, ionic strength, osmolality, and pH on fusion efficiency of cationic liposomes with Chinese hamster ovary (CHO) cells. The phase state of liposomes was analyzed by small angle neutron scattering (SANS). Our results showed that PC containing lipid membranes were organized in the lamellar phase. Here, fusion efficiency depended on buffer conditions and remained vanishingly small at physiological conditions. In contrast, SANS indicated the coexistence of very small (~50 nm) objects with larger, most likely lamellar structures for PE containing lipid particles. The fusion of such particles to cell membranes occurred with very high efficiency at all buffer conditions. We hypothesize that the altered phase state resulted in a highly reduced energetic barrier against fusion.
Nutraceutical Potential of Carica papaya in Metabolic Syndrome
Authors: Santana Lidiani F. , Inada Aline C. , Espirito Santo Bruna Larissa Spontoni do , Filiú Wander F. O. , Pott Arnildo , Alves Flávio M. , Guimarães Rita de Cássia A. , Freitas Karine de Cássia , Hiane Priscila A.
Published: July 2019

Carica papaya L. is a well-known fruit worldwide, and its highest production occurs in tropical and subtropical regions. The pulp contains vitamins A, C, and E, B complex vitamins, such as pantothenic acid and folate, and minerals, such as magnesium and potassium, as well as food fibers. Phenolic compounds, such as benzyl isothiocyanate, glucosinolates, tocopherols (α and δ), β-cryptoxanthin, β-carotene and carotenoids, are found in the seeds. The oil extracted from the seed principally presents oleic fatty acid followed by palmitic, linoleic and stearic acids, whereas the leaves have high contents of food fibers and polyphenolic compounds, flavonoids, saponins, pro-anthocyanins, tocopherol, and benzyl isothiocyanate. Studies demonstrated that the nutrients present in its composition have beneficial effects on the cardiovascular system, protecting it against cardiovascular illnesses and preventing harm caused by free radicals. It has also been reported that it aids in the treatment of diabetes mellitus and in the reduction of cholesterol levels. Thus, both the pulp and the other parts of the plant (leaves and seeds) present antioxidant, anti-hypertensive, hypoglycemic, and hypolipidemic actions, which, in turn, can contribute to the prevention and treatment of obesity and associated metabolic disorders.
Determinants of Exclusive Breastfeeding Cessation in the Early Postnatal Period among Culturally and Linguistically Diverse (CALD) Australian Mothers
Authors: Ogbo Felix Akpojene , Ezeh Osita Kingsley , Khanlari Sarah , Naz Sabrina , Senanayake Praween , Ahmed Kedir Y. , McKenzie Anne , Ogunsiji Olayide , Agho Kingsley , Page Andrew , Ussher Jane , Perz Janette , Barnett AM Bryanne , Eastwood John
Published: July 2019

There are limited epidemiological data on exclusive breastfeeding (EBF) among culturally and linguistically diverse (CALD) Australian mothers to advocate for targeted and/or culturally-appropriate interventions. This study investigated the determinants of EBF cessation in the early postnatal period among CALD Australian mothers in Sydney, Australia. The study used linked maternal and child health data from two local health districts in Australia (N = 25,407). Prevalence of maternal breastfeeding intention, skin-to-skin contact, EBF at birth, discharge, and the early postnatal period (1–4 weeks postnatal), were estimated. Multivariate logistic regression models were used to investigate determinants of EBF cessation in the early postnatal period. Most CALD Australian mothers had the intention to breastfeed (94.7%). Skin-to-skin contact (81.0%), EBF at delivery (91.0%), and at discharge (93.0%) were high. EBF remained high in the early postnatal period (91.4%). A lack of prenatal breastfeeding intention was the strongest determinant of EBF cessation (adjusted odds ratio [aOR] = 23.76, 95% CI: 18.63–30.30, for mothers with no prenatal breastfeeding intention and aOR = 6.15, 95% CI: 4.74–7.98, for those undecided). Other significant determinants of EBF cessation included a lack of partner support, antenatal and postnatal depression, intimate partner violence, low socioeconomic status, caesarean birth, and young maternal age (<20 years). Efforts to improve breastfeeding among women of CALD backgrounds in Australia should focus on women with vulnerabilities to maximise the benefits of EBF.
Dairy Product Consumption and Prostate Cancer Risk in the United States
Authors: Preble Isabella , Zhang Zhenzhen , Kopp Ryan , Garzotto Mark , Bobe Gerd , Shannon Jackilen , Takata Yumie
Published: July 2019

An ongoing controversy exists regarding the effect of dairy products on prostate cancer risk in observational studies. We prospectively investigated the associations between dairy product consumption and prostate cancer risk among men in the United States. After calculating pre-diagnostic intake of individual or subgroups of dairy products using a validated food frequency questionnaire, we estimated hazard ratios (HR) and 95% confidence intervals (CI) for pathologically-verified cases of incident prostate cancer among men, overall, or stratified by severity. Among 49,472 men, 4134 were diagnosed with prostate cancer during an average follow-up period of 11.2 years. The median total dairy intake was 101 g/1000 kcal. Consumption of total, individual, or subgroups of dairy products was not statistically significantly associated with prostate cancer risk overall (HR = 1.05, 95% CI = 0.96–1.15 comparing the highest with lowest quartile) or stratified by severity, except for regular-fat dairy product intake with late-stage prostate cancer risk (HR = 1.37, 95% CI = 1.04–1.82 comparing the highest with lowest quartile) and 2%-fat milk intake with advanced prostate cancer risk (HR = 1.14, 95% CI = 1.02–1.28 comparing the higher than median intake with no intake group). Our findings do not support the previously reported harmful impact of dairy consumption on overall prostate cancer risk among men in the United States.
Omega-3 Fatty Acids Survey in Men under Active Surveillance for Prostate Cancer: from Intake to Prostate Tissue Level
Authors: Moussa Hanane , Nguile-Makao Molière , Robitaille Karine , Guertin Marie-Hélène , Allaire Janie , Pelletier Jean-François , Moreel Xavier , Gevariya Nikunj , Diorio Caroline , Desmeules Patrice , Têtu Bernard , Lamarche Benoît , Julien Pierre , Fradet Vincent
Published: July 2019

Dietary omega-3 fatty acids (ω3), particularly long-chain ω3 (LCω3), have protective effects against prostate cancer (PCa) in experimental studies. Observational studies are conflicting, possibly because of the biomarker used. This study aimed at evaluating associations between grade reclassification and ω3 levels assessed in prostatic tissue, red blood cells (RBC), and diet. We conducted a validation cross-sectional study nested within a phase II clinical trial. We identified 157 men diagnosed with low-risk PCa who underwent a first active surveillance repeat prostate biopsy session. Fatty acid (FA) intake was assessed using a food frequency questionnaire and their levels measured in prostate tissue and RBC. Associations were evaluated using logistic regression. At first repeat biopsy session, 39 (25%) men had high-grade PCa (grade group ≥2). We found that high LCω3-eicosapentaenoic acid (EPA) level in prostate tissue (odds ratio (OR) 0.25; 95% (confidence interval (CI) 0.08–0.79; p-trend = 0.03) was associated with lower odds of high-grade PCa. Similar results were observed for LCω3 dietary intake (OR 0.30; 95% CI 0.11-0.83; p-trend = 0.02) but no association for RBC. LCω3-EPA levels in the target prostate tissue are inversely associated with high-grade PCa in men with low-risk PCa, supporting that prostate tissue FA, but not RBC FA, is a reliable biomarker of PCa risk.
Coffee Abundant in Chlorogenic Acids Reduces Abdominal Fat in Overweight Adults: A Randomized, Double-Blind, Controlled Trial
Authors: Watanabe Takuya , Kobayashi Shinichi , Yamaguchi Tohru , Hibi Masanobu , Fukuhara Ikuo , Osaki Noriko
Published: July 2019

The components of roasted or green coffee beans that promote abdominal fat reduction are not clear. We investigated the effects of daily consumption of coffee enriched in chlorogenic acids (CGA) on abdominal fat area in a randomized, double-blind, parallel controlled trial. Healthy, overweight men and women (n = 150, body mass index (BMI) ≥25 to <30 kg/m2) were randomly allocated to high-CGA (369 mg CGA/serving) or control (35 mg CGA/serving) coffee groups. Instant coffee was consumed once daily for 12 weeks, with four-week pre- and post-observation periods. Abdominal fat area and anthropometric measurements were analyzed at baseline and at four, eight, and 12 weeks, and 142 subjects completed the trial. Visceral fat area (VFA), total abdominal fat area (TFA), body weight, and waist circumference significantly decreased in the CGA group compared with the control group, with a group × time interaction (p < 0.001, p = 0.001, p = 0.025, and p = 0.001, respectively). Changes in VFA and TFA from baseline to 12 weeks were significantly greater in the CGA group than in the control group (−9.0 ± 13.9 cm2 vs. −1.0 ± 14.3 cm2, p < 0.001; −13.8 ± 22.9 cm2 vs. −2.0 ± 16.2 cm2, p < 0.001). No severe adverse events occurred. Consumption of high-CGA coffee for 12 weeks by overweight adults might lower VFA, TFA, BMI, and waist circumference.
Dietary Diversity of an Adult Solomon Islands Population
Authors: Horsey Bridget , Swanepoel Libby , Underhill Steven , Aliakbari Judith , Burkhart Sarah
Published: July 2019

Ongoing dietary transitions in the Solomon Islands has resulted in an over-reliance on commercially sourced foods, leading to food insecurity, and a subsequent rise in multiple forms of malnutrition. The aim of this study was to investigate the individual dietary diversity and food preferences of the adult population living in Auki, Solomon Islands. A cross-sectional study involving 133 adults was undertaken in the Auki district via an interviewer-administered questionnaire. Individual dietary diversity scores (DDS) were determined based on the results of a 24-h recall method. Overall mean DDS was 7.27 (range 2–12). Females and participants who lived outside the Auki town center had significantly higher dietary diversity scores. Low consumption of a variety of nutritious foods within food groups and high consumption of energy dense processed foods, indicates that diet quality is likely limited in some of this population. Participants desire for a diverse diet including local foods suggests that current dietary diversity status in this population may be influenced by food security rather than food preference.
Prospective Study of Attachment as a Predictor of Binge Eating, Emotional Eating and Weight Loss Two Years after Bariatric Surgery
Authors: Leung Samantha E. , Wnuk Susan , Jackson Timothy , Cassin Stephanie E. , Hawa Raed , Sockalingam Sanjeev
Published: July 2019

Bariatric surgery remains the most effective treatment for severe obesity, though post-surgical outcomes are variable with respect to long-term weight loss and eating-related psychopathology. Attachment style is an important variable affecting eating psychopathology among individuals with obesity. To date, studies examining eating psychopathology and attachment style in bariatric surgery populations have been limited to pre-surgery samples and cross-sectional study design. The current prospective study sought to determine whether attachment insecurity is associated with binge eating, emotional eating, and weight loss outcomes at 2-years post-surgery. Patients (n = 108) completed questionnaires on attachment style (ECR-16), binge eating (BES), emotional eating (EES), depression (PHQ-9), and anxiety (GAD-7). Multivariate linear regression analyses were conducted to examine the association between attachment insecurity and 2-years post-surgery disordered eating and percent total weight loss. Female gender was found to be a significant predictor of binge eating (p = 0.007) and emotional eating (p = 0.023) at 2-years post-surgery. Avoidant attachment (p = 0.009) was also found to be a significant predictor of binge eating at 2-years post-surgery. To our knowledge, this study is the first to explore attachment style as a predictor of long-term post-operative eating pathology and weight outcomes in bariatric surgery patients.
Evaluation of Athletes’ Food Choices during Competition with Use of Digital Images
Authors: Pelly Fiona E. , Thurecht Rachael
Published: July 2019

The selection of foods made by athletes during competition can impact performance, yet to date, the quality of their food choices has not been investigated. The aim of this study was to describe the food selection of athletes in a buffet-style dining hall setting in terms of diet quality, food variety, and volume of food and compare to their self-rating of their meal, reasons for the choosing the food items, access to previous nutrition advice, and use of nutrition labelling. A total of 81 athletes (42 females, 39 males) from 24 sports across 58 countries at the 2018 Commonwealth Games (Qld, Australia) participated in this study. A digital photograph was taken of the athletes’ meal after selection from the buffet and prior to consumption. Each participant was asked a series of questions in relation to their food selection. The photographs were coded into recommended serves of food groups based on the Australian Guide to Healthy Eating. The nutritional analysis and photograph of a standard serve size were used to quantify the energy and nutrients for the meal. Most athletes chose adequate quantities of macronutrients, which agreed with their reasons for the food choice, but the majority did not include fruit (80.2%) or dairy (65.4%) in their food selection, while 54% of males included discretionary foods (0.25–7.0 serves). The median self-rating for food choice was 8/10. Most reasons for food choices were nutritional attributes, sensory factors, performance, usual eating practices and physiological factors (e.g., satiety, gut comfort). This suggests that athletes may need more education on the quality of food selected from buffet settings.
Predictors of Dietary Diversity of Indigenous Food-Producing Households in Rural Fiji
Authors: O’Meara Lydia , Williams Susan L. , Hickes David , Brown Philip
Published: July 2019

Fiji, like other Pacific Islands, are undergoing economic and nutrition transitions that increase the risk of noncommunicable diseases (NCDs) due to changes of the food supply and dietary intake. This study aimed to examine dietary diversity (DD) in indigenous food-producing households in rural Fiji. Surveys were conducted with households from the Nadroga-Navosa, Namosi and Ba Provinces of Western Fiji in August 2018. Participants reported on foods consumed in the previous 24 h per the Household Dietary Diversity Score. Data was analysed using multinomial logistic regression. Of the 161 households, most exhibited medium DD (66%; M = 7.8 ± 1.5). Commonly consumed foods included sweets (98%), refined grains (97%) and roots/tubers (94%). The least consumed foods were orange-fleshed fruits (23%) and vegetables (35%), eggs (25%), legumes (32%) and dairy (32%). Households with medium DD were more likely to be unemployed (OR 3.2, p = 0.017) but less likely to have ≥6 occupants (OR = 0.4, p = 0.024) or purchase food ≥2 times/week (OR = 0.2, p = 0.023). Households with low DD were more likely to have low farm diversity (OR = 5.1, p = 0.017) or be unemployed (OR = 3.7, p = 0.047) but less likely to have ≥6 occupants (OR = 0.1, p = 0.001). During nutrition transitions, there is a need for public health initiatives to promote traditional diets high in vegetables, fruits and lean protein and agricultural initiatives to promote farm diversity.
Basal Diet Determined Long-Term Composition of the Gut Microbiome and Mouse Phenotype to a Greater Extent than Fecal Microbiome Transfer from Lean or Obese Human Donors
Authors: Rodriguez Daphne M. , Benninghoff Abby D. , Aardema Niklas D.J. , Phatak Sumira , Hintze Korry J.
Published: July 2019

The Western dietary pattern can alter the gut microbiome and cause obesity and metabolic disorders. To examine the interactions between diet, the microbiome, and obesity, we transplanted gut microbiota from lean or obese human donors into mice fed one of three diets for 22 weeks: (1) a control AIN93G diet; (2) the total Western diet (TWD), which mimics the American diet; or (3) a 45% high-fat diet-induced obesity (DIO) diet. We hypothesized that a fecal microbiome transfer (FMT) from obese donors would lead to an obese phenotype and aberrant glucose metabolism in recipient mice that would be exacerbated by consumption of the TWD or DIO diets. Prior to the FMT, the native microbiome was depleted using an established broad-spectrum antibiotic protocol. Interestingly, the human donor body type microbiome did not significantly affect final body weight or body composition in mice fed any of the experimental diets. Beta diversity analysis and linear discriminant analysis with effect size (LEfSe) showed that mice that received an FMT from obese donors had a significantly different microbiome compared to mice that received an FMT from lean donors. However, after 22 weeks, diet influenced the microbiome composition irrespective of donor body type, suggesting that diet is a key variable in the shaping of the gut microbiome after FMT.