bluuebunny/crossref_metadata_2025 huggingface dataset:
Streptomyces learnhanii sp. nov., unveiling a Mangrove-Derived Novel “Modern Actinobacteria” in Malaysia
Authors: Law Jodi Woan-Fei , Letchumanan Vengadesh , Hong Kar-Wai , Wong Sunny Hei , Ab Mutalib Nurul Syakima , He Ya-Wen , Chan Kok-Gan , Tan Loh Teng-Hern
Published: October 2023

Streptomyces learnhanii sp. nov. MUM 203JT was isolated from Malaysia mangrove soil. This Gram-positive bacterium produces pale greenish-yellow aerial and greyish-yellow substrate mycelia on ISP 2 agar. The taxonomy status of strain MUM 203JT was determined via a polyphasic approach comprising phenotypic observations, genomic and phylogenetic analyses, and chemotaxonomic analyses. The strain demonstrated typical Streptomyces features based on a series of phenotypic and chemotaxonomic evaluations. In particular, the cell wall peptidoglycan contained LL-diaminopimelic acid, and the predominant menaquinones detected include MK9(H8). Analysis of whole-cell sugars revealed the presence of glucose, ribose and mannose. The polar lipid profile of the strain comprised lipid, glycolipid, phospholipid, phosphatidylglycerol, phosphatidylinositol, phosphatidylethanolamine, phosphoglycolipid, and diphosphatidylglycerol. The major cellular fatty acids (>10.0 %) were anteiso-C15:0 (24.7 %), anteiso-C17:0 (16.4 %), iso-C16:0 (15.7 %), iso-C15:0 (11.5 %), and C16:0 (11.1 %). The closely related type strains for strain MUM 203JT, as determined by phylogenetic analysis, include Streptomyces coeruleorubidus JCM 4359T (98.8 %), Streptomyces coeruleoprunus JCM 6919T (98.5 %), Streptomyces thermocarboxydovorans NBRC 16324T (98.1 %). The DNA–DNA relatedness values between strain MUM 203JT and closely related type strains ranged from 10.7 ± 0.6 % to 23.3 ± 4.7 %. Strain MUM 203JT has a genome size of 6,446,886 bp, with DNA G + C content of 72.26 mol%. Based on the polyphasic study of strain MUM 203JT, it can be concluded that this strain represents a novel species, for which the name Streptomyces learnhanii sp. nov. is proposed. The type strain is MUM 203JT (= NBRC 114250T = MCCC 1K04200T).
A Panel of Three MicroRNA Signatures as a Potential Biomarker for CRC Screening Based on Stages and Functional Prediction Using Bioinformatic Analysis
Authors: Mohamed Syarah Syamimi , Ahmad Azmir , Ab Mutalib Nurul Syakima , Tengku Din Tengku Ahmad Damitri Al-Astani , Md Salleh Md Salzihan , Zakaria Andee Dzulkarnaen , Zakaria Zaidi
Published: October 2023

(1) Background: MicroRNA (miRNA) has been linked to colorectal cancer (CRC) tumorigenesis due to its post-transcriptional mechanism in targeting cancer-associated genes. Although miRNAs appear to be promising screening biomarkers, functional prediction analysis is required to shed light on their role in CRC tumorigenesis. Therefore, this study aims to identify the significantly deregulated miRNAs in CRC tumorigenesis. (2) Methods: Three upregulated miRNAs (hsa-miR-20a-5p, hsa-miR-21-5p, and hsa-miR210-3p) from 14 significant differentially expressed miRNAs (DEMs) were chosen from microarray profiling to be validated in plasma. Bioinformatics analyses showed that these miRNAs generally contributed to tumorigenesis, but only hsa-miR-20a-5p and hsa-miR-21-5p were specifically linked to CRC. Only two miRNAs showed a positive correlation when compared to their expression in plasma. However, further analysis showed that all three miRNAs in plasma were significantly difference between the early and advanced stages of CRC. ROC curve analysis was used to evaluate miRNAs’ diagnostic performance in the early and advanced stages. (3) Results: Collectively, hsa-miR-20a-5p showed the highest discriminative value (AUC= 0.82, sensitivity = 86%, and specificity= 88%) in discriminating early CRC, while both hsa-miR-21-5p and hsa-miR-210-3p give a perfect performance for advance CRC. In addition, the performance of all miRNAs’ combinations also gives a perfect performance for diagnosis in both early and advanced CRC, except the combination of hsa-miR-20a-5p and hsa-miR-210-3p. (4) Conclusions: A few potential miRNA panels as CRC biomarker is needed for better prediction of disease. The reflective circulating miRNAs can be contributed to by minimal invasive screening tools.
CYP Gene Expression and In Vivo Biological Effects of Khat Ethanol Extract, Cathinone and Cathine in Caenorhabditis elegans
Authors: Lim Sharoen Yu Ming , Alshawsh Mohammed Abdullah , Alshagga Mustafa , Kong Cin , Fang Chee-Mun , Pan Yan
Published: October 2023

The significant influence of khat, cathinone, and cathine on appetite suppression, reproduction impairment, and inhibitory effects on CYPs enzyme activity is widely recognised, but much remains unknown about its mode of action. This study demonstrated that exposure to high doses of KEE, cathinone, cathine and sibutramine at 12.5, 1.8, 1.8 and 1.8 mg/ml showed the most visible reduction in pharyngeal pumping rate, respectively. C. elegans showed an anomalous dynamic of reproduction rate upon exposure to these compounds but overall, showed a reduced amount of progeny. KEE, cathinone, and cathine extended the lifespan of C. elegans as compared to sibutramine and control with survival rate increments of 59.5%, 43.3%, and 15%, respectively. Quantitative RT-PCR results were insignificant, but cyp-14A3, cyp-34A9, and cyp-35A2 across all treatments were upregulated, ranging from >1 to 3-fold as compared to control. cyp genes expression could be upregulated to enhance the metabolism of khat extract, cathinone, cathine, and sibutramine in C. elegans.
A Review of Herbal Treatment for Functional Gastrointestinal Disorders and Infection
Authors: B Krupavaram , Babu A Kishore , Pillay Santhiya Manickam , Siang Tan Ching , Menon Bama V. V. , Paneerselvam Ganesh Sritheran , Ming Long Chiau , Al-Worafi Yaser Mohammed , Chooi Wen Han
Published: October 2023

Functional dyspepsia (FD), a common gastrointestinal condition, poses significant burdens on both individuals and society. In this article, we conducted PubMed searches using specific keywords to review clinical trials focusing on conventional and herbal treatments for dyspepsia as well as the adverse effects of non-herbal treatments. Dyspepsia can be managed using proton pump inhibitors, H2 blockers, and antacids. Additionally, we explore Tegaserod, a partial agonist of the 5-HT4 receptor, in the context of prokinetic medications. We summarise the research supporting the effectiveness of non-herbal dyspepsia treatment, considering factors beyond acid reduction, such as the placebo effect and the variability of dyspepsia symptoms, as discussed in the section on proton pump inhibitor (PPI) medication. Unlike most pharmacotherapies targeting a single mechanism, herbal medications often contain multiple active ingredients that can address several signalling pathways simultaneously. Notable herbs like fennel, cumin, aloe vera, ginger, and licorice have documented uses in the literature. Whether derived from a single plant or a combination, herbal treatments hold promises for addressing multiple conditions simultaneously. Therefore, evaluating herbal therapy at all stages of development should adhere to the same scientific rigour applied to chemically specific therapies.
Stock market indices in the market capitalization management of corporate agricultural enterprises
Authors: Hutorov Andrii
Published: October 2023

In globalization and production intensification, corporate agricultural enterprises increasingly seek investment resources for their development. Given the lack of sufficient funds from domestic investors and the transnational nature of economic activity, agricultural corporations are entering international capital markets. On the other hand, implementing corporate strategies for market capitalization management also involves optimizing or constantly increasing the market value of the business, which makes issuers of securities dependent on the stock market, financial risks, and psychological moods of investors. Since general trends determine the market conditions on the stock exchange, the financial management of corporate agricultural enterprises should consider the dynamics of share prices of both the leading issuers on the stock exchange and their industry representatives. Therefore, stock exchange indices are generalized indicators of this. The article aims to study stock market indices in the market capitalization management of corporate agricultural enterprises. It has been shown that stock indices are an essential financial market instrument, allowing investors to analyze market dynamics, assess risks, and formulate investment strategies. With the development of technology and the informatization of securities trading, the role of indices is only growing, and they reflect the dynamics of the economy and the latest investment demands. In corporate market capitalization management, stock indices play a crucial role by providing information to financial analysts, underwriters, and top management about general stock market trends and industry investment expectations. We have provided a brief genesis of stock market indices and defined their primary functions and principles of construction. The methodology for calculating stock exchange indices of corporate agricultural enterprises has been proposed. The trends in the development of Ukrainian agro-corporations for 2012-2022 have been identified, and the prominent trends for 2023 have been forecast. It has been defined that in order to prevent the deepening of the crisis in the corporate agrarian sector in 2023, along with state strategies and targeted programs, strategies for managing the market capitalization of corporate agricultural enterprises should be developed and/or refined based on strategic risk management, crisis management, international investment management, and behavioral finance, taking into account stock exchange indices as one of the strategic indicators of development in a globalized turbulent world.
Keywords: stock indices, stock market, market capitalization, corporate agricultural enterprises, financial management
An Insight into Distance Language Teaching/Learning from Secondary School Teachers’ and Learners’ Perspectives during and post COVID-19 in Saudi Arabia
Authors: Alshamrani Dania , Alsuhaibani Yasser
Published: October 2023

The aim of the study is to discuss the situation of implementing distance education from the perspective of secondary school English language teachers and learners in Saudi Arabia. The shift to distance education was determined on the 9th March and started on 15th March, 2020 respectively. The study has implemented a mixed-methods approach using two instruments; semi-instructed interviews and questionnaires; 1149 students and 398 teachers from both genders responded to the questionnaires, 3 teachers and 4 learners participated in the interviews. Results showed an overall acceptance for distance English language teaching and learning. The findings also revealed the main challenges for different aspects. From the management aspects, the findings confirmed an increase in teachers’ workload and learners’ assignments in distance learning that negatively affects the learning process. Turning to the educational issues, results indicated concerns about assessment accuracy and learner participation in distance learning. This study has found that technical issues generally play a vital role in missing classes and losing concentration.
Identification of Diatom Genera at Different Ghats of Saryu River at Ayodhya Uttar Pradesh for Forensic Consideration
Authors: - Esha Shukla , - Pooja Rana , - Vetolu P Tunyi , - Munish Kumar Mishra
Published: October 2023

Diatoms are unicellular, photosynthetic (autotrophic), eukaryotic algae. They belong to class Bacillariophyceae. In this work, 18 water samples were collected (3 from each site) from 6 different Ghats of Ayodhya i.e. Guptar Ghat, Raj Ghat, Ram Ghat, Lakshman Ghat, Janki Ghat, Naya Ghat. Water samples were collected from the surface of water. Following research, a total of 27 genera of diatoms were found. These diatom genera had significant ecological importance and were also crucial to criminal investigations involving post-mortem or anti-mortem drowning. Apart from 27 genera identification few diatom genera were found as site specific, these are Cymbella, Gyrosigma, Surirella, Fragilaria virescens, Adalfia , Navicula, Brachysira, Anomoeoneis, Frauenfeldii.
Introducing Adaptive Multilevel Inverter as a PV Generator Interface to Power System
Authors: - D. MUNTHAZ , - K. CHANDRA SEKHAR
Published: October 2023

Inverters assume significant part in photovoltaic (PV) frameworks combination into power matrix. Inverter influence power quality (PQ), as well as strength of force network. PQ become conspicuous issue for the majority power organizations because of generally utilized nonlinear burdens . In this paper, a Versatile Staggered Inverter (MLI) is proposed to reaction PQ issues in PV frameworks coordinated into power network. The methodology of this proposed technique alludes to the Fourier investigation by following sine waveform with flight of stairs sythesis. By controlling θ_n as indicated by Fourier examination, the ouput voltage of the proposed MLI can gain a decent sinusoidal trademark and the voltage music can be counterbalanced. Come about reproductions show that absolute consonant twisting (THD) of Versatile MLI is far superior to traditional MLI.

All the above examination is completed SIMULINK and simpower framework in MATLAB Programming climate. This strategy is confirmed by building fifteen level Versatile staggered inverter drive with and without channel utilizing Simulink/MATLAB, the outcomes acquired are analyzed and results are introduced.
Bus Ticket Reservation And Seat Allocation System Using Blockchain Technology
Authors: - S.SUTHAN , - A.MAHESH M.E.,
Published: October 2023

The Bus Ticket Reservation System is an online platform that provides a user-friendly interface for booking and managing bus tickets. The system offers various features such as seat reservation, ticket booking, cancellations, and route inquiries. When all bus tickets are reserved, passengers receive a prompt to make a booking. When a admin accepts the passenger's request, the system automatically sends a notification through email and mobile number, informing the passenger that their request has been accepted. The passenger is then prompted to make the payment process to confirm the seat. Once the payment is completed, the ticket is confirmed, and the passenger is ready to embark on their journey. During boarding, passengers can choose luggage retrieval options: Ticket number input and image upload. For lost luggage, use the complaint section with a boarding day image. You can visualize historical passenger travel data using a bar chart to compare online and offline ticket bookings, while also showing the total number of passengers, total seats, and unbooked tickets.
Ludwig’s Angina – A Case Report
Authors: - Megalah Selvamani , - Prepageran Narayanan
Published: October 2023

Ludwing angina is defined as progressive cellulitis of the submandibular space. It is a deep neck space infection. The two compartments affected are the sublingual and sub mylohyoid space. It progresses rapidly and needs to be addressed urgently. Early identification and initiating treatment will aid in reducing morbidity and mortality.
Visualizing Kingship in a Time of Change
Authors: Schwerda Mira Xenia
Published: October 2023

Despite artistic engagement with photography in Iran almost immediately after the invention of the daguerreotype in 1839, the field of Islamic art history has had difficulty accepting the modern period and the medium of photography as part of its discipline. Studies on painted Iranian portraiture have often stopped before the introduction of photography, and only in more recent years has photographic portraiture and its influence on painting been examined. Due to this nascent state of the field, large gaps exist even on more traditional topics, such as the question of royal portraiture. This article presents the first examination of photographic royal portraiture and the visualization of kingship during the Iranian Constitutional Revolution (1905-1911). This topic, in comparison with earlier Iranian painted royal portraiture, has received considerably less attention. Photographic portraiture, together with printed and painted examples, from the reigns of the Qajar rulers Nasir al-Din Shah (r. 1848-1896), Muzaffar al-Din Shah (r. 1896-1907), Muhammad ʿAli Shah (r. 1907-1909), and Ahmad Shah (r. 1909-1925), will be analysed in connection with social and political developments in order to better understand the development of royal image making during a time of political turmoil.
Transforming Pharmacovigilance Using Gen AI: Innovations in Aggregate Reporting, Signal Detection, and Safety Surveillance
Authors: Praveen John , Kumar CM Krishna , Channappa Ajay Haralur
Published: October 2023

Pharmacovigilance, the science of monitoring and evaluating drug safety, plays a crucial role in ensuring patient well-being and public health. With the advent of artificial intelligence (AI), specifically Gen AI, pharmacovigilance has witnessed a transformative shift. Gen AI's advanced capabilities in real-time signal detection, automated reporting, and data integration have significantly enhanced the efficiency and accuracy of drug safety monitoring and surveillance.
This article explores the role of Gen AI in pharmacovigilance, emphasizing its potential to revolutionize aggregate reporting, signal detection, risk assessment, and safety surveillance. It delves into the challenges and considerations that come with adopting AI in pharmacovigilance, such as ethical and regulatory implications, data privacy and security concerns, and the need for algorithm transparency and interpretability.
The article also discusses the future directions and opportunities for Gen AI in pharmacovigilance which include enhanced signal detection algorithms, personalized safety assessments, and predictive risk modelling and incorporation of emerging technologies like blockchain and IoT that can complement Gen AI and improve data security and real-time monitoring.
Collaborative efforts and data sharing among stakeholders are essential for maximizing Gen AI's potential in pharmacovigilance. Public-private partnerships and global pharmacovigilance networks can accelerate the adoption of AI technologies and drive innovation in drug safety monitoring.
In conclusion, Gen AI presents a transformative opportunity for pharmacovigilance, promising safer medications and improved patient outcomes. Embracing responsible AI adoption, addressing ethical considerations, and encouraging further research are key to unlocking the full potential of Gen AI in advancing drug safety and public health.
PROFILING OF CLINICAL DYNAMICS OF TYPE 2 DIABETES MELLITUS IN PATIENTS: A PERSPECTIVE REVIEW
Authors: Ikwuka Aloysius Obinna , Omoju Daniel Inioluwa , Mahanera Ousainou K
Published: October 2023

Type 2 diabetes mellitus (T2DM), also known as Non-Insulin Dependent Diabetes Mellitus (NIDDM) is one of the common metabolic disorders in the world. T2DM accounts for around 90% of all cases of diabetes mellitus, afflicting millions worldwide. It is a significant global health burden with a steadily increasing prevalence.  In T2DM, the response to insulin is diminished, and this is defined as insulin resistance. Risk factors for T2DM are diverse. Some are modifiable, and others are not. Modifiable risk factors include overweight/obesity, lack of exercise or physical inactivity, poor nutrition, etc. Non-modifiable risk factors include age, ethnicity/race, family history, history of gestational diabetes mellitus, etc. The starting points and mainstays of treatment for T2DM are diet and lifestyle modifications such as increased physical activity and stoppage of smoking. In addition to the diet and lifestyle modifications, drugs are also used in the management of T2DM. This study aimed to profile the clinical dynamics of type 2 diabetes mellitus in patients. Current literatures from different databases including MEDLINE, PubMed, EMBASE, CINAHL, Google Scholar, etc. on the topic were searched online and reviewed.
CLUSTERING AND MULTINOMIAL LOGIT ANALYSIS OF FACTORS INFLUENCING HOUSEHOLD RESIDENTIAL LOCATION CHOICE IN THE WASHINGTON METROPOLITAN AREA
Authors: MIRZAHOSSEIN Hamid , BAKHTIARI Ali , NOSRATI Mahdi , JIN Xia
Published: October 2023

The vast range of location alternatives and the preference heterogeneity have made it challenging to model, analyse, and predict the location choice process. In this study, we propose a two-step analytical model to focus on lowering the magnitude of these choices. The Transportation Planning Board's 2007-2008 household survey was used in the Washington metropolitan area, consisting of 3722 Traffic Analysis Zones (TAZ). First, location choice alternatives were clustered based on TAZs into homogeneous groups. These TAZs were categorized based on accessibility to public transport, population density, and employment density. Then, the Multinomial Logit (MNL) model was employed to allow the interpretation of the relationship between the clustered areas and the socio-economic characteristics. Four clustering algorithms were compared in terms of efficiency, and the mini-batch k-means performed the best based on the silhouette coefficient. Overall, households tend to prefer suburban areas as household size and the number of owned vehicles increase. Urban areas were selected with an increase in income, number of household workers, number of unemployed looking for a job, number of part-time employees, number of retirees, and the presence of university students. This paper contributes to the current trend of using unsupervised algorithms in the urban planning literature.
DEMOGRAPHIC AND PHYSICAL ASPECTS OF GENTRIFICATION IN RELATION TO RESILIENCE OF URBAN LOCALITIES: CASE STUDY OF THE RENOVATED DISTRICT IN THE CITY OF PRAGUE
Authors: KOURILOVA Jana , ALBERTOVA Denisa , PELUCHA Martin
Published: October 2023

Gentrification is a complex process taking place in major cities around the world. This process varies from city to city and it is influenced by the specific conditions of each country. Both positive and negative impacts of gentrification can affect a city’s resilience. The aim of this paper is to assess and verify how residential and commercial gentrification is taking place in two selected locations of the municipal district Holešovice in the City of Prague. Both locations are attractive due to their proximity to the city centre. The paper focuses on two aspects of gentrification, i.e., the outcomes of demographic changes and its physical dimension, assessed by the visual complexity of building appearance. The results show the relationship and temporal continuity of residential and commercial gentrification. With its findings, the paper contributes to the knowledge base of urban studies following the identified growing need for commercial facilities in urban districts as a result of demographic changes.
Characterization of biomaterials with reference to biocompatibility dedicated for patient-specific finger implants
Authors: Byrski Adam , Kopernik Magdalena , Major Łukasz , Kasperkiewicz Katarzyna , Dyner Marcin , Lackner Juergen M. , Lumenta David , Major Roman
Published: October 2023

Purpose

The research was focused on determining basic mechanical properties, surface and phase structure taking into consideration basic cytotoxicity analysis towards human cells.

Methods

Biological tests were performed on human C-12302 fibroblasts cells using 3D-printed Ti6Al4V alloy (Ti64), produced by laser-based powder bed fusion (LB-PBF) and Alumina Toughened Zirconia 20 (ATZ20), produced by lithography-based ceramic manufacturing (LCM). Surface modifications included electropolishing, and hydroxyapatite or hydroxyapatite/zinc coating. Structure analysis was carried out using a variety of techniques such as X-Ray diffraction, scanning electron microscopy (SEM), transmission electron microscopy (TEM), and confocal laser scanning microscopy (CLSM), followed by mechanical properties evaluation using nanoindentation testing.

Results

Samples subjected to surface modifications showed diversity among surface and phase structure and mechanical properties. However, the cytotoxicity towards tested cells was not significantly higher than the control. Though, a trend was noted among the materials analysed, indicating that HAp/Zn coating on Ti64 and ATZ20 resulted in the best biological performance

Conclusions

Hydroxyapatite coating on Ti64 and ATZ20 resulted in the best biological properties. Tested materials are suitable for in vivo toxicity testing.
Quantitative evaluation of stereoscopic augmented reality visualization using an optical see-through head-mounted display
Authors: Żuk Magdalena , Majak Marcin , Szczur Izabela , Popek Michał , Świątek-Najwer Ewelina
Published: October 2023

Purpose

The objectives of the current study were to propose a calibration method for accurate augmented reality visualisation using an optical see-through head-mounted display, and to qualitatively evaluate visualisation accuracy for the application in computer assisted surgery.

Methods

An adaptation of stereo single-point active alignment method was proposed as the calibration procedure together with verification Three tests were performed: display of points in 3D space, on the plane, and on the surface of a skull phantom on inexperience users ( 5 participants) and experienced users ( 17 participants).

Results

The highest accuracy of visualization was obtained for skull phantom visualisation for an inexperienced user (3.00 mm, std 0.75 mm), while the lowest accuracy was obtained in a 3D visualisation test for an inexperienced user (22.95 mm, std 18.04 mm). The largest error was related to the depth component and amounted to 18.49 mm, std 18.10 mm for an inexperienced user.

Conclusions

It is possible to achieve relatively high visualisation accuracy (less than 5 mm for visualisation in space) for selected users but providing it for the group of inexperienced users seems to remain a major challenge. The accuracy of point indication can be substantially and statistically significantly increased by visualising objects on surfaces. The proposed methods and obtained results can serve as a basis for further implementation of augmented reality visualisation on an optical see-through head-mounted display in applications requiring high-quality augmented reality guidance of manual tasks.
Elements Of Child Law In The Commonwealth Caribbean
Authors: McDowell Zanifa
Published: October 2023

Elements of Child Law is a comprehensive study of legitimacy, status of children legislation, parental rights, maintenance, family provision and succession to property, custody, adoption and care and protection issues. The book includes a thorough discussion of the Convention on the Rights of the Child adopted by the United Nations in 1989 and its ramifications for the region in the last ten years. All relevant Caribbean statutes and their relationships to current case law are examined.
Natural Honey (Raw Honey): Insights on Quality, Composition, Economic and Health Effects: A Comprehensive Review
Authors: Edo Great Iruoghene , Onoharigho Favour Ogheneoruese , Akpoghelie Patrick Othuke , Akpoghelie Emmanuel Oghenekome , Agbo Joy Johnson , Agoh Endurance , Lawal Rashidat Adelola
Published: October 2023

Natural honey is one of the most significant foods produced and consumed globally, it has pleasing sensory characteristics such a light colour, as well as a recognizable flavor and aroma. In addition, natural honey has been associated with potential biological properties since it contains organic acids, sugars, minerals, enzymes, phenolic, volatile compounds, methylglyoxal, amino acids, and vitamins. All of these features make this viscous substance extremely desirable by consumers for health and wellness purposes and likewise by manufacturing industries for production purposes thus increasing its market value. Since honey plays a vital role in balancing human nutrition being a better alternative to sugar, and further serves as a natural raw material in most industrial products the world over, its socio-economic importance to human development and industrial output cannot be overemphasized. The income generating and job creating capacity of the honey industry has been beneficial both to corporate organizations and various governments of the world. It is therefore the aim of this study to provide information on the quality, composition, health effects and economics of this high value viscous liquid.
Designing the CLAIO 2022 Conference Program With Combinatorial Optimization Techniques
Authors: Marenco Javier
Published: October 2023

Designing the scientific program of a technical conference is a nontrivial task, in particular when there are many parallel sessions to be scheduled. In this setting, each session must be composed by a thematically coherent set of presentations, whereas sessions attracting a similar
audience should not be scheduled simultaneously. In this work we explore this issue, by proposing a combinatorial optimization model representing this situation and by presenting computational techniques that allow to obtain good-quality solutions for this problem. We illustrate the application
of these techniques to the scientific program of the XXI Latin-Iberoamerican Conference in Operations Research, which took place in December 2022. We present experiments assessing the general contribution of the computational machinery proposed in this work, concluding that these techniques
allow to automatically design the scientific program of a mid- to large-sized conference while taking into account the mentioned criteria.
Developing child-friendly cities: Young children’s participation in urban planning
Authors: Wilhelmsen Terese , Øvreås Steinar , Roll-Hansen Hege , Bjerknes Anne-Line , Thorrud Simen
Published: October 2023

This article is based on a collaborative project between a municipality and a research team, aiming to investigate participatory methods that promote young children’s interest and participation in, and access to express their views in connection with, urban planning processes. The research question was: What characterizes a child-friendly city for young children and their families? The article is framed within the perspective of children’s rights, affordance and child-friendly outdoor environments. The project has employed multiple research methods. The participants were children (aged 3-6) and parents from three early childhood education and care institutions. The children (n=16) participated in guided tours, field conversations, drawing and constructive play using Lego. The parents (n=14) participated by identifying the locations that they preferred to frequent with their children, and a structured survey was used to identify what the parents liked and disliked about the places they identified. Our findings indicate that there are four important features that characterise a child-friendly city: 1) The availability of ‘green lungs’, 2) Creative and challenging play opportunities, 3) Places for the whole family, and 4) Safe playgrounds and walking routes. We discuss how better knowledge of what characterizes a child-friendly city can contribute to planning processes.
Diabetes and substance use: a perspective within drug rehabilitation
Authors: Alhassan Abuelgasim Elrasheed A. , Elrashid Weaam , Alshehhi Aref , Al Mamari Samya , Abu Raddaha Mahmoud , Assaf Mansour , Elliott Simon
Published: October 2023

Diabetes mellitus has become increasingly more common and diagnosed within the global population. Coupled with the continued prevalence of substance use, there are some distinct considerations for users suffering (knowingly or unknowingly) from type 1 or type 2 diabetes. The various different types of drugs of abuse including central nervous system stimulants, depressants, and hallucinogens present varying direct and indirect complications for diabetes based on their physiological and psychological effects ranging from non-compliance with medication to an increased risk of hypoglycaemia, hyperglycaemia, and/or ketoacidosis. This perspective highlights these issues supported by the drug history and toxicological findings in patients undergoing drug rehabilitation in the United Arab Emirates (UAE) demonstrating the use of alcohol, amphetamines, benzodiazepines, cannabis, opiates/opioids (especially tramadol), pregabalin, and synthetic cannabinoids. Physicians and drug clinic professionals should be aware of the contraindications of substance use and diabetes with a view to educating patients and healthcare professionals within such clinical settings.
Quantile Loss Function Empowered Machine Learning Models for Predicting Carotid Arterial Blood Flow Characteristics
Authors: Rani T. Raja , Srimal Woshan , Al Shibli Abdullah , Al Bakri Nooh Zayid Suwaid , Siraj Mohamed , Radhika T. S. L.
Published: October 2023

This research presents a novel approach using machine learning models with the quantile loss function to predict blood flow characteristics, specifically the wall shear stress, in the common carotid artery and its bifurcated segments, the internal and external carotid arteries. The dataset for training these models was generated through a numerical model developed for the idealized artery. This model represented blood as an incompressible Newtonian fluid and the artery as an elastic pipe with varying material properties, simulating different flow conditions. The findings of this study revealed that the quantile linear regression model is the most reliable in predicting the target variable, i.e., wall shear stress in the common carotid artery. On the other hand, the quantile gradient boosting algorithm demonstrated exceptional performance in predicting wall shear stress in the bifurcated segments. Through this study, the blood velocity and the wall shear stress in the common carotid artery are identified as the most important features affecting the wall shear stress in the internal carotid artery, while the blood velocity and the blood pressure affected the same in the external carotid artery the most. Furthermore, for a given record of the feature dataset, the study revealed the efficacy of the quantile linear-regression model in capturing a possible prevalence of atherosclerotic conditions in the internal carotid artery. But then, it was not very successful in identifying the same in the external carotid artery. However, due to the use of idealized conditions in the study, these findings need comprehensive clinical verification.
Legal Consequences of Dual and Multiple Nationality: Practice of International Legal Regulation
Authors:   Kokoc Group, Moscow, Russian Federation, Adzhba Diana D.
Published: October 2023

Introduction. The article dwells on the international legal cooperation on resolution of the consequences of dual and multiple nationality concerning extradition of bi- and polypatrids, resolution of investment disputes with their participation and provision of diplomatic protection. Theoretical Basis. Methods. The theoretical basis of the present study was based on doctrinal and legal sources, as well as legal precedents in the field of extradition of persons with dual and multiple nationality, resolution of investment disputes, and diplomatic protection. Formal-legal, comparative-legal, historical, and predictive methods were used in the research. Results. Dual and multiple nationality appear more and more widespread phenomena which is caused by the tendencies of modern interstate communication. In the absence of effective international legal regulation, in particular treaty regulation, a large number of disputes arises in connection with the legal status of bi- and polypatrids, among which the most urgent are those in the field of extradition, resolution of investment disputes and provision of diplomatic protection. The well-established approach in the area of bi- and polipatrizm implies the application of the principle of “effective nationality” in cases involving such persons. Discussion and Conclusion. The admissibility and conditions for application of effective nationality principle are frequently not stipulated in the international treaties (on extradition, on protection of investments, on dual nationality), therefore it seems advisable to supplement this kind of treaties with appropriate provisions on the procedure of effective nationality principle application.
Actual Issues of Realization of the Right to Defense at the Stage of Initiation of a Criminal Case
Authors:   Russian State University of Justice, Moscow, Russia, Lunina Natalia N.
Published: October 2023

The article is devoted to the implementation of the right to protection by increasing the effectiveness of the consideration of complaints by courts in accordance with Article 125 of the Code of Criminal Procedure at the stage of initiation of a criminal case. Based on the analysis of the norms of Articles 6.1, 29, 144 of the Code of Criminal Procedure of the Russian Federation, the positions of the Constitutional Court of the Russian Federation, the Supreme Court of the Russian Federation, attention is drawn to the problems that arise when considering complaints about decisions to initiate criminal proceedings and refusal to initiate criminal proceedings on reporting a crime. It is noted that the existing means of protecting the violated right are insufficient. The purpose of the study is the theoretical and practical justification of the need to improve the criminal procedure legislation and the practice of its application.
Termination Indemnity is a Universal Way of Cease of Obligations in Russian Civil Law
Authors:   Sevastopol’ State University, Sevastopol, Russia, Monastyrsky Yuri Е.
Published: October 2023

The obligatory claim is the most important mass property value in contemporary civil turnover. It has unlike choses its intangible nature and special regime of its emergency and termination. Stability of commercial ties is also dependent on universal tool of discontinuance of obligation in line with subsequent agreements or legally designated events. Termination indemnity can be considered as such. In accordance with article 409 of RF Civil Code it can be established by an agreement. Due to authors opinion that should not be interpreted contra legem.
Emocreatividad o el corazón emocional de la creatividad
Authors: Rodríguez Hernández Antonio
Published: October 2023

What is the relationship between the emotions that we human beings experience and the creative potential that exclusively characterizes us as a species? Is competent emotionality connected to our divergent capacities? Is there an emotional dimension of the creative construct? Can we use, from a scientific perspective, the concept of emotional creativity? What do we understand by emotional creativity? This article, of a theoretical nature, seeks to provide answers to these questions, in an effort to transcend the dissociation between the emotional and the creative. Traditionally our emotions have been relegated to the sphere of the impulsive and the non-cognitive dimension and, therefore, to the lower thought processes; not only at the evaluative level but also neuropsychologically, given its subcortical nature. For its part, creativity belongs to the category of higher processes, both in the cognitive productivity continuum and because of its neocortical location. The reflection provided here is based on the idea that emotionality, from a competency perspective, and creativity are not disjointed sets, but intersected and that, therefore, we can establish an emotional dimension of the creative construct, which authors prior to conceptualized as emotional creativity. We will start on this journey of theoretical synthesis of the antecedent concept that divergent affectivity supposed, to connect with the milestone that implied the implantation of the curricular area “Emotional Education and for Creativity”, which will serve as a bridge to connect with the concept of emotional creativity and from this, conclude in our conception of emocreative synthesis and its methodological concretion.
Study on acute poisoning cases brought for Medico Legal Autopsy in Gandhi Medical College, Secunderabad
Authors: G.Mahender  , D.Laxmi  , K.Sudhakar Suresh  , T.Nagendra Babu
Published: October 2023

Background: Regular epidemiological investigations are essential for gaining insights into the incidence ofpoisoning in various geographical areas. The purpose of this study was to assess the characteristics and trendsof deaths due to poisoning in Gandhi Medical College, Secunderabad.Methods: Hospital records, inquest reports, post-mortem reports and toxicological analysis reports were analysedamong various age groups, sex, type and manner of poisoning. Snake bite poisoning cases were excluded.Results: Out of 318 cases, we got positive toxicological analysis report for 287 (90.2%) cases. In our studypredominance of male cases 259(81.45%) compared to female cases 59(18.55%) reported. In the age group mostinvolved was 21-30 yrs 107 cases (34%) followed by 31-40 yrs 82 (26%), 41-50 yrs 49 (15%). Organophosphatepoisoning reported in high number of cases 189(65.85%) followed by paraquat poisoning 44(15.33%), tabletpoisoning 23(2.01%), Sulphuric acid poisoning 22(7.67%) and others 9 (3.14%) (Rodenticide, phenol, pyrethroid,nitrite). In manner of death suicidal cases 311(97.80%) reported more followed by accidental cases 7 (2.20%). Insuicidal cases, economic constraints as a reason were outnumbered 209 cases (67.20%) followed by health issues52(16.72%), academic failure 35(11.25%), love failure 15(4.82%). In region wise, rural areas reported more cases244(76.73%) when compared to urban area 74 (23.27%). In season wise, more cases reported in April to July 148cases (46.50%) followed by December to March 97 cases (30.5%), August to November 73 (23%). Zero homicidalpoisoning noted.Conclusion: Organophosphate poisoning in active male population of rural areas with economic constraintswere reported to be predominant.
Post Mortem analysis of electrolytes in vitreous humour to determine time since death
Authors: Ganesh .D. Niturkar  , Shruti .G. Saraf
Published: October 2023

Background: It has been found that so many biochemical materials, including electrolytes, remain remarkablystable after death while others show varying degrees of change; hence, the analysis of electrolytes in vitreoushumour has great medico-legal importance.Method: 95 autopsies were studied by making a puncture 5–6 mm away from the limbus by using a 10 ml sterilesyringe and 20 gauze needles. Aspirated vitreous was poured into a rubber stopped vial. The collected fluid wassent to the biochemistry department for electrolyte analysis. The analysis was carried out using the iron selectiveelectrode method, and the results were noted and compared.Results: The PM interval for 27 cases (28.4%) was < 12 hours, 32 cases (33.6%) was between 12-24 hours, and36 cases (37.8%) was >24 hours. In the study of different electrolytes, the sodium chloride value remainedinsignificant, but the potassium value had a highly significant p value (p<0.001). The highest mean value ofpotassium 10.62 (±1.90) in accidental falls and least in snake bite deaths was 6.7 (±0.23).Conclusion: The present pragmatic study has proved that vitreous potassium is the single best parameter toestimate and predict post mortem death accurately.
Implicancia jurídica de la garantía mobiliaria en la transferencia de propiedad vehicular a tercero en Lima, 2022 (Caso Res. 1778-2022-SUNARP-TR)
Authors:   Universidad Privada Norbert Wiener, del Villar Reymundo Pedro Moisés , Ramírez Peña Isabel ,   Universidad Privada Norbert Wiener
Published: October 2023

Introducción: La Superintendencia Nacional de los Registros Públicos limita las transferencias de vehículos con gravámenes en garantía mobiliaria, lo que genera problemas a nivel notarial. Objetivo: Analizar la implicancia jurídica de la garantía mobiliaria en la transferencia de propiedad vehicular a tercero en Lima, 2022. Metodología: Se utilizó el enfoque cualitativo, método hermenéutico, técnica análisis documental, con un diseño basado en el estudio de caso. Resultado: Se identificó que las teorías son relevantes en el aspecto económico y la libre circulación de los bienes, y se invoca al llamamiento a un Pleno Casatorio Civil sobre garantías. Conclusión: Se analizó que existe implicancia jurídica de la garantía mobiliaria en la transferencia de propiedad vehicular a tercero en Lima, 2022. Lo más relevante es la interrelación entre la garantía mobiliaria y la transferencia de propiedad vehicular a tercero, en consonancia con los principios de la teoría del título, el modo y el principio de erga omnes. Lo que más nos ayudó fue mantener comunicación directa con las autoridades competentes para obtener datos exactos y actualizados, aunque encontramos limitaciones en el acceso a fuentes doctrinarias y el plazo establecido ha dificultado el desarrollo de este caso de estudio.
Desarrollo de la Competencia Comunicativa Discursiva en Estudiantes de tercer grado de primaria a través de Mapas Conceptuales y Libros Digitales
Authors: Inagán Campaña Amilbia Inés
Published: October 2023

En esta investigación se validó el uso del software Cmap Tools y libros digitales como recursos tecnológicos para el desarrollo de la competencia comunicativa discursiva en estudiantes de grado tercero de primaria de la Institución Educativa Leopoldo Pizarro González sede La Pola 1 y 2 del municipio de Miranda Cauca. Se diseñó, implementó y evaluó una propuesta pedagógica la cual contó con 10 actividades agrupadas en cuatro categorías: exploratorio o de reconocimiento, de fundamentación, de interdisciplinariedad y de proyección. Además, se caracterizó por interactuar con la tecnología, reconocer el software Cmap Tools, buscar literatura infantil digital, estructurar pensamiento oral, comunicarse con asertividad, ser el protagonista, comunicándose con recursos tecnológicos, articulando saberes, recomendando literatura infantil y proyectando lo aprehendido en la feria del libro infantil. En ésta se obtuvo los siguientes resultados: mejoría en sus desempeños, comunicación clara, puntual, con buen tono de voz y vocalización, gestos y ayuda visual, fluidez y argumentación, captando la atención de auditorio partícipe, dando coherencia al discurso, con vocabulario afín y justificación, finalmente, haciendo uso de esquemas gráficos o mapas cognitivos con los cuales proyectaron asertivamente un mejor discurso oral. Al final se dará a conocer las conclusiones y recomendaciones del proceso implementado. Así que, este trabajo de grado nació del interés pedagógico que surge por transformar los procesos didácticos en clase, donde los recursos tecnológicos se usaron como herramienta para desarrollar la competencia comunicativa discursiva haciendo uso de las herramientas tecnológicas (portátiles) y otras tecnologías que favorecieron la comunicación asertiva de los estudiantes de grado tercero. Entonces, se generó el siguiente interrogante ¿Qué efecto tiene la implementación de una propuesta pedagógica mediada por los recursos tecnológicos Cmap Tools y libros digitales, para desarrollar la competencia comunicativa discursiva en los estudiantes de tercer grado de la institución educativa Leopoldo Pizarro González? Ahora bien, la respuesta al interrogante sería haciendo uso de estrategias innovadoras donde se utilice como herramienta principal las tecnologías, puesto que los recursos tecnológicos logran hacer significativos los aprendizajes.