bluuebunny/crossref_metadata_2025 huggingface dataset:
PHYTOCHEMICAL ANALYSIS OF EXTRACTS FROM THE ATLANTIC FOREST SPECIES WOOD
Authors: Santos Hanna Lisa Leffever Ribeiro dos , Souza Natalia , Macedo Nathalia Rodrigues , Ramos João Paulo da Silva , Dias Júnior Ananias Francisco , Nascimento Alexandre
Published: August 2022

The extractives are responsible for some characteristics of wood, such as color, smell, natural resistance to rot, taste, and abrasive properties. In addition, its content and composition vary between species of wood. The objective of this work was to present a phytochemical analysis of wood extractives of native species of the Atlantic Forest, aiming at the characterization of some classes of secondary metabolites. The phytochemical tests for the detection of classes of metabolites present in Croton Urucurana Baill, Pelthoforum dubium (Spreng.) Taub., Jacaranda cuspidifolia Mart., and Hymenaea courbaril L were carried out with crude wood, hydrophilic extract (methanol), and lipophilic extract (cyclohexane). Phytochemical analysis detected the presence of alkaloids, phenolic compounds, and triterpenoids in all the hydrophilic extracts of the species studied. Saponins were only detected in P. dubium and J. cuspidifolia. Phytochemical analysis permitted the identification of several metabolites, suggesting possible pharmacological actions of the species studied.
Fitoquímica: potencialidades biológicas dos biomas brasileiros - Volume 2
Authors: Miranda Mayker Lazaro Dantas
Published: August 2022

Esta obra constituiu-se a partir de um processo colaborativo entre pesquisadores brasileiros da área de Produtos Naturais que se destacaram e apresentaram seus trabalhos de pesquisa neste espaço formativo. Resultou, também, da necessidade de haver em língua portuguesa um compêndio que atualizasse os conhecimentos e pesquisas desenvolvidas nesta área científica. Abordou-se desta maneira o rico estudo fitoquímico de diferentes espécies de plantas ocorrentes em todos os biomas brasileiros, incluindo seus potenciais biológicos. Alguns profissionais que atuam na farmacognosia, ciências farmacêuticas, biologia, farmácia, biotecnologia e química de produtos naturais contribuíram para construção deste livro. Agradecemos aos autores pelo empenho, disponibilidade e dedicação para o desenvolvimento e conclusão dessa obra. Esperamos também que a mesma sirva de instrumento didático-pedagógico para estudantes, professores dos diversos níveis de ensino e demais interessados pela temática.
“Não foram o ouro e a prata que seduziram o homem branco na Amazônia: foram as plantas” (Otto Gottlieb e Walter Mors, 1978).
МЕТОДОЛОГІЯ ДОСЛІДЖЕННЯ ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ФІЗИЧНОЇ КУЛЬТУРИ ДО ОРГАНІЗАЦІЇ ІНДИВІДУАЛЬНОЇ РОБОТИ З УЧНЯМИ
Authors: Алєксєєв О. О.
Published: August 2022

У статті проаналізовано питання конкретизації методологічних підходів у контексті професійної підготовки майбутніх учителів фізичної культури до організації індивідуальної роботи з учнями. Узагальнено, що методологія педагогічних досліджень розвивається з урахуванням і практичним застосуванням наукових підходів, що складають основу теорії педагогіки та сприяють розвитку й оновленню змісту освіти. Установлено, що сприйняття, засвоєння і використання засадничих основ методології освіти та педагогіки у процесі професійної підготовки майбутніх учителів фізичної культури до організації індивідуальної роботи з учнями дасть змогу викладачам і студентам поєднувати розуміння і пояснення структури освіти та освітньої діяльності зі структурою буття конкретної людини; прогнозувати сучасні напрями розвитку системи фізкультурної освіти в загальноосвітній школі; здійснювати проєктування й організацію освітнього процесу у вищій школі з метою розроблення, апробації, упровадження й удосконалення експериментальної системи на засадах реалізації окреслених методологічних підходів. Базуючись на власному досвіді професійної підготовки майбутніх учителів фізичної культури, апелюючи до напрацювань сучасних дослідників, котрі вивчали різноманітні аспекти підготовки студентів за спеціальностями 014.11 Середня освіта (Фізична культура) та 017 Фізична культура і спорт, визначено методологічні підходи, які відображають специфіку реалізації завдань дослідно-експериментальної роботи. До загальнонаукових методологічних підходів віднесено системний, синергетичний, діяльнісний, діалектичний, гуманістичний, процесуальний, компетентнісний, структурний. До конкретно-наукових методологічних платформ вивчення особливостей професійної підготовки майбутніх учителів фізичної культури до організації індивідуальної роботи з учнями віднесено: аксіологічний, акмеологічний, особистісний, нормативний, суб’єктний, контекстний.
Relación entre producción y las características fenotípicas en Coffea arabica L.
Authors: Unigarro Carlos Andrés , Medina-Rivera Rubén , Flórez Claudia Patricia
Published: August 2022

En cultivos perennes, como café, desarrollar una variedad comercial requiere de 20 a 25 años, motivo por el cual, el estudio de las relaciones entre producción y las características fenotípicas facilita los procesos de selección y avance generacional dentro del programa de mejoramiento genético. La correlación existente entre dos variables no implica necesariamente una relación causal, porque su efecto puede ser indirecto al depender de otras variables. La causalidad puede evaluarse mediante el análisis de sendero, al determinar los efectos de una correlación. En el presente estudio se determinó la relación y el efecto de algunas características fenotípicas con la producción de café cereza, durante el primer período productivo del cultivo. En la Estación Experimental Naranjal de Cenicafé (Chinchiná-Caldas-Colombia), se evaluó la asociación entre siete características fenotípicas y la producción de café cereza en 18 genotipos C. arabica. Las relaciones se analizaron mediante correlaciones genéticas, mientras que los efectos directos e indirectos se determinaron con el análisis de sendero. Los resultados mostraron que la cantidad de flores y el área foliar tienen una asociación directa y alta con la producción de café cereza por árbol, la cual se corroboró al evaluar los efectos directos con el análisis de sendero. La altura presentó una relación inversa y baja con la producción, con efecto directo. El número de nudos con flores y el peso promedio de un fruto presentaron un efecto indirecto sobre la producción. Estos resultados validan observaciones previas y confirman la importancia del área foliar como componente de producción.
Independent Evidence for Earlier Formation Epochs of Fossil Groups of Galaxies through the Intracluster Light: The Case for RX J100742.53+380046.6
Authors: Dupke Renato A. , Jimenez-Teja Yolanda , Su Yuanyuan , R. Carrasco Eleazar , M. Koekemoer Anton , M. Batalha Rebeca , Johnson Lucas , Irwin Jimmy , MIller Eric , Dimauro Paola , de Oliveira Nícolas O. L. , Vilchez Jose
Published: August 2022

Fossil groups (FG) of galaxies still present a puzzle to theories of structure formation. Despite the low number of bright galaxies, they have relatively high velocity dispersions and ICM temperatures often corresponding to cluster-like potential wells. Their measured concentrations are typically high, indicating early formation epochs as expected from the originally proposed scenario for their origin as being older undisturbed systems. This is, however, in contradiction with the typical lack of expected well developed cool cores. Here, we apply a cluster dynamical indicator recently discovered in the intracluster light fraction (ICLf) to a classic FG, RX J1000742.53+380046.6, to assess its dynamical state. We also refine that indicator to use as an independent age estimator. We find negative radial temperature and metal abundance gradients, the abundance achieving supersolar values at the hot core. The X-ray flux concentration is consistent with that of cool core systems. The ICLf analysis provides an independent probe of the system’s dynamical state and shows that the system is very relaxed, more than all clusters, where the same analysis has been performed. The specific ICLf is about 6 times higher, than any of the clusters previously analyzed, which is consistent with an older noninteractive galaxy system that had its last merging event within the last ∼5 Gyr. The specific ICLf is predicted to be an important new tool to identify fossil systems and to constrain the relative age of clusters.
GJ 3929: High-precision Photometric and Doppler Characterization of an Exo-Venus and Its Hot, Mini-Neptune-mass Companion
Authors: Beard Corey , Robertson Paul , Kanodia Shubham , Lubin Jack , Cañas Caleb I. , Gupta Arvind F. , Holcomb Rae , Jones Sinclaire , Libby-Roberts Jessica E. , Lin Andrea S. J. , Mahadevan Suvrath , Stefánsson Guđmundur , Bender Chad F. , Blake Cullen H. , Cochran William D. , Endl Michael , Everett Mark , Ford Eric B. , Fredrick Connor , Halverson Samuel , Hebb Leslie , Li Dan , Logsdon Sarah E. , Luhn Jacob , McElwain Michael W. , Metcalf Andrew J. , Ninan Joe P. , Rajagopal Jayadev , Roy Arpita , Schutte Maria , Schwab Christian , Terrien Ryan C. , Wisniewski John , Wright Jason T.
Published: August 2022

We detail the follow-up and characterization of a transiting exo-Venus identified by TESS, GJ 3929b (TOI-2013b), and its nontransiting companion planet, GJ 3929c (TOI-2013c). GJ 3929b is an Earth-sized exoplanet in its star’s Venus zone (P

b
= 2.616272 ± 0.000005 days; S
b
=

17.3

−
0.7

+
0.8

S
⊕) orbiting a nearby M dwarf. GJ 3929c is most likely a nontransiting sub-Neptune. Using the new, ultraprecise NEID spectrometer on the WIYN 3.5 m Telescope at Kitt Peak National Observatory, we are able to modify the mass constraints of planet b reported in previous works and consequently improve the significance of the mass measurement to almost 4σ confidence (M

b
= 1.75 ± 0.45 M
⊕). We further adjust the orbital period of planet c from its alias at 14.30 ± 0.03 days to the likely true period of 15.04 ± 0.03 days, and we adjust its minimum mass to

m
sin
i

= 5.71 ± 0.92 M
⊕. Using the diffuser-assisted ARCTIC imager on the ARC 3.5 m telescope at Apache Point Observatory, in addition to publicly available TESS and LCOGT photometry, we are able to constrain the radius of planet b to R

p
= 1.09 ± 0.04 R
⊕. GJ 3929b is a top candidate for transmission spectroscopy in its size regime (TSM = 14 ± 4), and future atmospheric studies of GJ 3929b stand to shed light on the nature of small planets orbiting M dwarfs.
The Effects of a Magnetar Engine on the Gamma-Ray Burst-associated Supernovae: Application to Double-peaked SN 2006aj
Authors: Zhang Zhen-Dong , Yu Yun-Wei , Liu Liang-Duan
Published: August 2022

A millisecond magnetar engine has been widely suggested to exist in gamma-ray burst (GRB) phenomena, in view of its substantial influences on the GRB afterglow emission. In this paper, we investigate the effects of the magnetar engine on the supernova (SN) emission, which is associated with long GRBs and, specifically, confront the model with the observational data of SN 2006aj/GRB 060218. SN 2006aj is featured by its remarkable double-peaked ultraviolet-optical (UV-opt) light curves. By fitting these light curves, we demonstrate that the first peak can be well accounted for by the breakout emission of the shock driven by the magnetar wind, while the primary supernova emission is also partly powered by the energy injection from the magnetar. The magnetic field strength of the magnetar is constrained to be ∼1015 G, which is in good agreement with the common results inferred from the afterglow emission of long GRBs. In more detail, it is further suggested that the UV excess in the late emission of the supernova could also be due to the leakage of the nonthermal emission of the pulsar wind nebula, if some ad hoc conditions can be satisfied. The consistency between the model and the SN 2006aj observation indicates that the magnetar engine is likely to be ubiquitous in the GRB phenomena and even further intensify their connection with the phenomena of superluminous supernovae.
Can Cooling and Heating Functions Be Modeled with Homogeneous Radiation Fields?
Authors: Robinson David , Avestruz Camille , Gnedin Nickolay Y.
Published: August 2022

Cooling and heating functions describe how radiative processes impact the thermal state of a gas as a function of its temperature and other physical properties. In a most general case the functions depend on the detailed distributions of ionic species and on the radiation spectrum. Hence, these functions may vary on a very wide range of spatial and temporal scales. In this paper, we explore cooling and heating functions between 5 ≤ z ≤ 10 in simulated galaxies from the Cosmic Reionization On Computers project. We compare three functions: (1) the actual cooling and heating rates of hydrodynamic cells as a function of cell temperature, (2) the median cooling and heating functions computed using median interstellar medium (ISM) properties (median ISM), and (3) the median of the cooling and heating functions of all gas cells (instantaneous). We find that the median ISM and instantaneous approaches to finding a median cooling and heating function give identical results within the spread due to cell-to-cell variation. However, the actual cooling (heating) rates experienced by the gas at different temperatures in the simulations do not correspond to either summarized cooling (heating) functions. In other words, the thermodynamics of the gas in the simulations cannot be described by a single set of a cooling plus a heating function with a spatially constant radiation field that could be computed with common tools, such as CLOUDY.
KIC 2857323: A Double-mode High-amplitude δ Scuti Star with Amplitude Decline of the First Overtone Mode
Authors: Yang Tao-Zhi , Zuo Zhao-Yu , Sun Xiao-Ya , Tang Rui-Xuan , Esamdin Ali
Published: August 2022

We investigate the pulsating behavior of KIC 2857323 using high-precision observations from the Kepler mission. Fourier analysis of 4 yr time-series data reveals five independent frequencies for the light variation. Among them, two strong frequencies f
1 and f
3 with a period ratio of 0.774 identify this star as a double-mode (i.e., the fundamental mode F0 and first overtone mode F1) high-amplitude δ Scuti star (HADS). Seismic modeling using the two radial modes F0 and F1 indicates that KIC 2857323 is a main-sequence star with mass M = 1.78 ± 0.02 M
⊙ and metallicity Z from 0.009 to 0.012. We analyze the phase and amplitude variations of F0 and F1 using the phase modulation method and find that the first overtone mode F1 shows a slow decline in amplitude. We discuss several possible causes for the amplitude variation and speculate that the amplitude decline in this star may be due to pulsation energy loss. We note that KIC 2857323 is the first double-mode HADS to show amplitude decline and warrants further study to ascertain its nature.
Two new species of Trichoglossum (Geoglossaceae, Ascomycota) from south Mexico
Authors: de la Fuente Javier Isaac , García-Jiménez Jesús , Raymundo Tania , Gohar Daniyal , Bahram Mohammad , Sánchez-Flores Marcos , Valenzuela Ricardo , Pinzón Juan P.
Published: August 2022

Two new species of Trichoglossum are described from south Mexico based on morphological and molecular evidence. Trichoglossum caespitosum is characterized by the caespitose ascomata, rough and coiled paraphyses and the ascospores with 9–11 septa. Trichoglossum tropicale is characterized by the capitate ascomata, clavate and straight paraphyses and the ascospores with 10–12 septa. Both species grow in the tropical forests of the Yucatán peninsula. Here we provide descriptions and photographs for these species, together with a phylogenetic analyses based on the DNA sequences of nuc rDNA (ITS region and 28S gene) and a comparative table for the species known for America.
Student Success Through Mastery Learning in a Nursing Health Assessment Course
Authors: Morgan Erin
Published: August 2022

Background:

A nurse's ability to assess a patient is foundational to practice. The educational theory of mastery learning can be applied to teach physical assessment in nursing to define standards, provide feedback, and encourage a baseline level of student competence required in the new
American Association of Colleges of Nursing's Essentials
.

Method:

A baccalaureate nursing health assessment course was redesigned in mastery learning to include detailed rubrics, faculty exemplar videos, and laboratory time for practice. Student-produced physical assessment videos served as formative assessments for each body system.

Results:

Six students did not reach the assigned mastery level on one of the formative assessments, allowing for quick identification and remediation. All of the students passed the end-of-course physical assessment examination, meeting the goal of the course redesign.

Conclusion:

Mastery Learning Theory allowed all students to practice skills, receive feedback, and gain confidence to master physical assessment.

[
J Nurs Educ
. 2022;61(12):720–723.]
Approximate solution for the nonlinear fractional order mathematical model
Authors: Mahreen Kahkashan , Ain Qura Tul , Rahman Gauhar , Abdalla Bahaaeldin , Shah Kamal , Abdeljawad Thabet
Published: August 2022

Health organizations are working to reduce the outbreak of infectious diseases with the help of several techniques so that exposure to infectious diseases can be minimized. Mathematics is also an important tool in the study of epidemiology. Mathematical modeling presents mathematical expressions and offers a clear view of how variables and interactions between variables affect the results. The objective of this work is to solve the mathematical model of MERS-CoV with the simplest, easiest and most proficient techniques considering the fractional Caputo derivative. To acquire the approximate solution, we apply the Adomian decomposition technique coupled with the Laplace transformation. Also, a convergence analysis of the method is conducted. For the comparison of the obtained results, we apply another semi-analytic technique called the homotopy perturbation method and compare the results. We also investigate the positivity and boundedness of the selected model. The dynamics and solution of the MERS-CoV compartmental mathematical fractional order model and its transmission between the human populace and the camels are investigated graphically for $ \theta = 0.5, \, 0.7, \, 0.9, \, 1.0 $. It is seen that the recommended schemes are proficient and powerful for the given model considering the fractional Caputo derivative.
Properties of PEDOT:PSS on Black Silicon and Hybrid Textured Surfaces
Authors: Abdulkadir Auwal , Abdul Aziz Azlan , Pakhuruddin Mohd Zamir
Published: August 2022

This work investigates properties of Poly (3,4-ethylenedioxythiophene)–poly (styrene sulfonate) (PEDOT:PSS) on black silicon (nanotextured) and hybrid textured (nanotextured/microtextured) surfaces. The black silicon (b-Si) surface is fabricated using two-step metal-assisted chemical etching (MACE) process on crystalline silicon (c-Si) while the hybrid textures are fabricated using two-step MACE process on microscale pyramids. With PEDOT:PSS, weighted average reflection (WAR) reduces from 9.2% to 7.7% for b-Si and from 7.2% to 5.2% for hybrid textures. This is due to the anti-reflective (AR) property of the polymer. Electrical characterizations of the PEDOT:PSS layer reveal higher sheet resistance (Rs), lower hole concentration (nh) and improved mobility (μh) with the presence of the surface textures on c-Si, in comparison to the results from planar c-Si reference.
Analysis of the Migration Process of Concrete Layers during Compaction
Authors: Trtík Tomáš , Chylík Roman , Fladr Josef , Vaskova Jitka
Published: August 2022

The article describes the behavior of a fresh concrete exposed to the effects of vibration. The individually deposited layers of concrete mix are able to migrate in the vertical and horizontal direction in the specimen or structure. This phenomenon is simulated using successively deposited layers of colored concrete of defined height. The specimens were exposed to vibrations of variable frequency and amplitude. The degree of interconnection between the layers is determined by using regular sections across the specimens to observe the differences in the movement and interconnection of the layers for different consistencies of the concrete mix. The results summarized in this paper present new results of continuous research aimed at a more detailed description of the vibration behaviour of fresh concrete, as this phenomenon is relatively marginally addressed in the current standards.
Thermal Degradation of Hybridize Doped Poly(Dioctylfluorene) Film with Polydimethylsiloxane
Authors: Abdul Hisam Nurfatin Syafiqah , Abdul Rahim Nor Azura , Abd Jalil Jalilah , Wei Chew Kang
Published: August 2022

The purpose of this study is to evaluate the thermal degradation of hybridize doped poly(dioctylfluorene) (PF8) film with polydimethylsiloxane (PDMS). The hybridized PF8/PDMS films were produced using solvent casting technique. The poly(dioctylfluorene) was dissolved using chloroform and subsequently polydimethylsiloxane was added prior mixing. Three different concentrations of PF8 were used to prepare the doped film. After casting, the samples were put in an oven at 100°C for 5 minutes for curing process. Later the thermal degradation test was conducted on the prepared sample for the duration of 1 hour, 2 hours, 3 hours and 24 hours to observe the effect of temperature on the photoluminescence properties of PF8. UV-visible spectroscopy was mainly used to measure the absorption intensity of the hybridized materials. It was configured that the optimum doped concentration for PF8 with PDMS is by using 5.0×10-3 mol of PF8. This is due to a good solubility of PF8 and easy to be casted.
Effect of Alkaline Environment on Mechanical Properties of Molded Composite Reinforcement
Authors: Lagin Juraj , Girgle Frantisek , Kostiha Vojtěch , Rozsypalová Iva , Stepanek Petr
Published: August 2022

Composite (FRP) reinforcement is used in the construction industry mainly because of its high resistance to aggressive environments. The production technology and design of straight FRP members is now very well understood. However, when designing concrete elements, it is usually necessary to adapt the reinforcement to the requirements of the construction and to design curved (bent) members. These then undergo structural changes in their cross-section during manufacture, which can have a major effect on their service life and load-bearing capacity. This paper describes the problem of degradation of shaped composite reinforcement in an aggressive alkaline environment and presents experimentally determined values of tensile strength.
An Empirical Study on the Effects of Sea Ice on Ship Tonnage per Centimeter and Cargo Operations
Authors: Turna İdris , Kara Gökhan , Danişman Devrim Bülent
Published: August 2022

Abstract Many ports around the world are threatened by sea ice. Access by merchant ships to these ports is ensured by ice-breaking services. For the sensitivity of calculations of the amount of cargo on vessels carrying out loading and discharging in waters covered with ice,
the calculations need to be modified. This study aims to investigate the effects of sea ice in different thicknesses on the calculations of the cargo amounts, especially the effects on the tonnage per centimeter (TPC) values of the vessels. There is a limited number of studies on ice resistance
of zero-speed vessels. An experimental study was performed to gauge the impact of ice on vessel draughts on a scale ship model. The scaled TPC weights were applied under two separate loading conditions on the scale model ship. Such processes were repeated for various ice thicknesses. The results
indicated that an increase in TPC values was in a linear relationship with ice thickness and was found under both loading conditions. In analyses based on the scale model according to the draft marks, the ice friction created an overloaded case. In the stability booklets, it is assumed that
adding the amount of increase in TPC value as a correction would resolve disputes over the amount of loaded cargo and can circumvent overloading cases.
Two Unique Deep Ocean Operations With the Mir Submersibles
Authors: Sagalevich Anatoly M.
Published: August 2022

Abstract The Mir-1 and Mir-2 submersibles (6,000 m) were built in 1987. In over 30 years of use, the submersibles were deployed in many deep ocean operations for scientific research; for filming with Hollywood, IMAX, BBC, etc.; as well as for dives to solve
special tasks in great depths. In this article, the author discusses two unique operations with Mirs: live broadcast from the Titanic (3,800 m) and the attempt to raise the safety capsule of the nuclear submarine Komsomolets in the Norwegian sea (1,700 m).
Research on Sampling System for Abyssal Sediment Based on Image Recognition Technology
Authors: Ruan Dongrui , Chen Jiawang , Jiang Jiqing , Peng Xiaoqing , Zhou Peng , Huang Yue
Published: August 2022

Abstract The pressure-holding sampling technology for deep-sea sediments has been identified as a prerequisite for studying the sedimentary environment with respect to the mechanical and biological characteristics of sediments. Thus, in this study, we designed a set of abyssal
sediment sampling systems based on image recognition technology. First, a system camera was used to obtain the movement trajectory of the sampling cone in the laboratory simulation scene. After collecting the data of the image including the sampler, we preprocessed the data using an underwater
image restoration method based on the dark channel prior. An image recognition unit was used to verify that the position of the sampling cone meets the requirement. The main control unit controlled the actuator of the sampling device to accurately control the position of the sampling cone.
Furthermore, we used the Mask R-convolutional neural network architecture to build the network framework for controlling the expansion and braking of the sampler. The experimental results showed that the system achieved a very high detection accuracy for the position of the sampling cone.
Expression analysis of HIF-3α as a potent prognostic biomarker in various types of human cancers
Authors: Yazdani Behnaz , Sirous Hajar
Published: August 2022

Background and purpose

Hypoxia-inducible factors (HIFs) are transcription factors that get activated and stabilized in the heterodimerized form under hypoxic conditions. many studies have reported the importance of the HIF-1α and HIF-2α activity in biological pathways of hypoxic cancer cells. However, the importance of HIF-3α in a variety of cancers remains unknown.

Experimental approach:

The expression profile of 13 different types of cancer samples from the Cancer Genome Atlas (TCGA) database were subjected to normalization, and differential gene expression analysis was performed using computational algorithms by R programming. Receiver operating characteristic tests and survival analyses were carried out for HIF-α subunits in different cancers.

Findings / Results:

The expression status of HIF-3α was notably less in all cancer samples in contrast to their adjacent normal tissues. The expression degree of HIF-1α varied among distinct types of cancer and the expression degree of HIF-2α was lower in nearly all types of cancers. HIF-3α had very weak diagnostic potential, while HIF-2α had better diagnostic potential in most types of cancers compared to HIF-1α. Patients who had a higher level of HIF-3α had better survival, while the higher expression level of HIF-1α and HIF-2α were associated with worse survival in many types of cancers.

Conclusion and implications:

Our findings showed that each HIF-α subunit had a unique heterogeneous expression pattern in different classes of cancers. The expression level of each HIF-α subunit correlated differently with the stages, tumor sizes, and survival rate of patients from different classes of TCGA cancers.
Cold agglutinin autoimmune haemolytic anaemia as an initial presentation of diffuse large B cell lymphoma
Authors: Ranjan Vivek , Dhingra Gaurav , Gupta Nitin , Khillan Kamini , Rana Rashmi
Published: August 2022

Cold agglutinin disease, commonly affecting females in the their seventh decade of life, is otherwise a rare entity and has an incidence of one case per million people per year. Cold reactive antibody is associated with autoimmune haemolytic anaemia (AIHA) in approximately 20% of the cases. Although the occurrence of AIHA in patients with non-Hodgkin's lymphomas is well known, aggressive lymphomas such as diffuse large B cell lymphoma (DLBCL) initially presenting as cold agglutinin AIHA is extremely rare. Here, we describe a case of DLBCL presenting few months before the diagnosis as cold antibody-AIHA.
Adding pre-emptive anticholinergics to antipsychotics
Authors: Chatterjee Kaushik , Dangi Ankit , Sharma Rachit , Yadav Prateek , Chauhan Vinay Singh , Prakash Jyoti
Published: August 2022

Anti-psychotics are the mainstay of treatment for Schizophrenia and psychotic disorders. Historically, anticholinergics have been prescribed to prevent or treat extrapyramidal side effects (EPS) associated with first-generation antipsychotics (FGAs). Even though newer antipsychotics are associated with markedly lower rates of EPS, concurrent anticholinergic use remains high. Use of these medications has potential for long-term side effects, worsening of EPS and poor adherence. We have briefly discussed the limited association between second-generation antipsychotics (SGAs) and EPS, the efficacy of anticholinergics for different types of EPS, and summarized various national and international guidelines on the subject. In conclusion, there is no evidence for prophylactic use of anticholinergics with antipsychotics. Clinicians need to guard against this tendency to be unduly cautious.
Integrating the Fairlight CVI into the video workflow
Authors: Nunn D.J.E.
Published: August 2022

The Fairlight Computer Video Instrument (CVI) is one of the earliest video synthesisers, released in 1984. Over time the aesthetic of its effects has evolved from revolutionary to retro. Although MIDI was developed at around the same time, the CVI is controllable via RS232 rather than MIDI. This paper reviews its history and applications in live and studio-based video production environments. A method is outlined for controlling the CVI that allows sequencing of control data, effect automation, and integration with a digital audio workstation. Results are presented from a system using Logic Pro X for sequencing and Processing for MIDI-serial conversion.
Federal Policy Related to Antidepressant Medications
Authors: Baldwin Paul
Published: August 2022

For more than 20 years, the Centers for Medicare & Medicaid Services (CMS) has shown an interest in the use of psychoactive medications in the nursing facility environment. While the US government's primary target has been the atypical antipsychotic drugs, antidepressants were grouped with other psychoactive medications as subjects of scrutiny.
Influence of mycophenolate mofetil dosage and plasma levels on the occurrence of chronic lung allograft dysfunction in lung transplants: a retrospective cohort analysis
Authors: Steinack Carolin , Saurer Philipp , Gautschi Fiorenza , Hage René , Ortmanns Gernot , Schuurmans Macé M. , Gaisl Thomas
Published: August 2022

INTRODUCTION: Development of chronic lung allograft dysfunction is a limiting factor for post-lung transplant survival. We evaluated whether the dose of the immunosuppressant mycophenolate mofetil or plasma concentrations of the active metabolite mycophenolic acid affect the development of chronic lung allograft dysfunction.
METHODS: In this retrospective cohort study we recruited 71 patients with a lung transplant between 2010 and 2014 which survived the first year after transplantation up to 1 July 2021. An event-time-analytical Cox proportional-hazards regression model with time-varying-covariates (18,431 measurements for MPA, mycophenolate mofetil dosage, lymphocytes) was used to predict chronic lung allograft dysfunction, with adjustment for sociodemographic factors and lung function at baseline.
RESULTS: 37 patients did not develop chronic lung allograft dysfunction (age 41.3 ± 15.6 years, baseline FEV1 95.5 ± 19.1% predicted) and 34 patients developed chronic lung allograft dysfunction (age 50.9 ± 13.3 years, baseline FEV1 102.2 ± 25.4% predicted). Mean mycophenolic acid did not differ significantly between the groups (2.8 ± 1.7 and 3.0 ± 2.3 mg/l; p = 0.724). In the first 4 post-transplant years the death rate was 25%. A total of 50% of the patients died by the ninth post-transplant year. There was a dose-effect relationship between mycophenolate mofetil dosage, mycophenolic acid (r2 = 0.02, p <0.001), as well as lymphocyte levels (r2 = –0.007, p <0.001), but only the traditional risk factor age predicted chronic lung allograft dysfunction. Continuously measured mycophenolic acid did not predict chronic lung allograft dysfunction (hazard ratio 0.98, 95% confidence interval 0.90–1.06, p = 0.64 over a period of 382.97 patient-years).
CONCLUSION: Mycophenolate mofetil dosage and mycophenolic acid were not associated with chronic lung allograft dysfunction development. Thus, the mycophenolate mofetil dose or mycophenolic acid plasma concentration are not a primary factor related to organ rejection, but chronic lung allograft dysfunction may be influenced by other components of immunosuppression or other factors.
Cover Jurnal
Authors: Jurnal Cover
Published: August 2022

Cover Jurnal
PERLINDUNGAN HUKUM PADA ANAK KORBAN PENCABULAN DALAM PROSES PENYIDIKAN (Studi Kasus Laporan Polisi No. LP/222/XI/2019/SU/Res.Tapteng, Tertanggal 18 November 2019)
Authors: Simaremare Elysa Sani Merynda , Kalo Syafrudin , Hamdan M. , Marlina Marlina
Published: August 2022

ABSTRAKPenyelidikan dan penyidikan terhadap Anak Korban tindak pidana pencabulan pada keluarga sulit untuk dilaksanakan karena sering mendapat perlawanan dalam keluarga. Sebagaimana contoh kasus dalam penelitian ini, pencabulan yang dilakukan oleh Ayah Kandung terhadap anaknya, dimana saudara kandungnya ikut dalam pencabulan. Mengangkat topik penelitian terhadap Laporan Polisi No. 222/XI/SU/2019/Res.Tapteng tentang tindak pidana pencabulan dengan permasalahan yang dikaji pengaturan hukum tentang perlindungan hukum bagi Anak Korban tindak pidana pencabulan dalam tahap penyelidikan dan penyidikannya; Proses penyelidikan dan penyidikan Laporan Polisi tersebut; dan upaya yang dilakukan Penyidik Satreskrim Polres Tapteng dan instansi-instansi terkait. Penelitian merupakan penelitian hukum normatif bersifat deskriptif, selanjutnya dianalisis dengan metode analisis kualitatif. Disimpulkan dalam penyelidikan dan penyidikan terhadap tindak pidana pencabulan terhadap Anak Korban oleh keluarga kerap mengalami kendala, salah satunya kendala biaya dan sulitnya mengumpulkan bukti-bukti dan saksi-saksi karena keluarga sulit untuk dimintai keteranga. Upaya yang dilakukan oleh penyidik yakni Polres Tapteng berdasarkan kebijakan kriminal dengan pendekatan represif jugan mempercepat pemberkasan perkara guna mampu dilimpahkan ke Kejaksaan Negeri Sibolga. Disamping itu juga melakukan pendekatan dengan konsep kebijakan non-penal berupa memberikan pendidikan seks usia dini dan pengenalan pentingnya menjaga alat reproduksi serta penyuluhan hukum untuk memotivasi anak-anak di sekolah-sekolah dalam memberikan informasi mengenai kejadian-kejadian tindak pidana yang dialaminya.Kata Kunci: perlindungan hukum; anak korban pencabulan; dan ayah kandung
PERLINDUNGAN HUKUM TERHADAP JAMINAN AGUNAN DALAM PERJANJIAN KREDIT MODAL KERJA (KMK) (Studi Kasus Putusan No.466/Pdt.G/2020/PT.Mdn)
Authors: Ita Ita , Dewi Ayu Trisna , Sitompul Rina Melati
Published: August 2022

ABSTRACTThe thing which is the most disadvantaged party is the debtor, but it is possible that the bank as the creditor will also suffer losses from these problems.The problem in this research is how to regulate the law regardingthe debtor in the working capital credit agreement, how is the settlement process if the debtor is in default and how is the Judge's Consideration in Decision No. 466/Pdt/2020/PT MDN. This research method uses normative legal research and analytical descriptive research.The results of this study, legal arrangements regarding debtors in credit agreementsworking capital based on the provisions of Article 1338 of the Civil Code. The process of settling debtors with outstanding performance in a credit agreement can be carried out by saving credit through rescheduling, reconditioning and restructuring. Furthermore,settlement of credit by means of the execution of the executive title by the creditor, sale of objects to be objects of collateral through auctions, sales of collateral in underhand. The judge's consideration in the decision no. 466/2020/PT.MDN, namely the plaintiff or defendant I, must comply with the agreement that has been agreed uponincluding the existence of the plaintiff's bad credit, which should be Defendant I submitting a default suit to the Binjai District Court or submitting a request for execution to the Binjai District Court or other courts anywhere within the territory of the Republic of Indonesia, instead of submitting it to another institution, namely to Defendant II to resolve legal issues between the plaintiff and Defendant I.It is recommended that the creditor must be able to anticipate things that are done to the debtor due to default by conducting deliberation to find the best solution, moreover the debtor has good faith to pay the pending debt in accordance with the agreement that has been made.Keywords: Legal Protection, Guarantee, Credit Agreement
TANGGUNG JAWAB PPAT ATAS BEA PEROLEHAN HAK ATAS TANAH DAN BANGUNAN (BPHTB) PADA AKTA JUAL BELI TANAH DAN BANGUNAN DI KOTA MEDAN
Authors: Limbong Tania Mayshara , Dewi Ayu Trisna , Sitompul Rina Melati
Published: August 2022

ABSTRACTPPAT in making the deed is to ensure that the payment of BPHTB the debt has been paid by the taxpayer. For this reason, it is necessary to study the role of PPAT in the imposition of BPHTB in the transfer of land rights and building, the legal consequences of the imposition of BPHTB in the deed of sale and purchase of land and buildings and the mechanism for imposing BPHTB in the deed of sale and purchase. Type The research used in writing this thesis is juridical normative empirical, which is descriptive analysis. The data collection techniques used used is literature study and field research. The role of PPAT in The imposition of BPHTB in the Transfer of Land and Building Rights, namely convey the necessary information related to the imposition process BPHTB in the imposition of BPHTB tax on the transfer of land rights and building. The legal consequences of the imposition of BPHTB in the Deed of Sale and Purchase of Land and The building, namely the Sale and Purchase Deed, cannot be carried out before the BPHTB is signed the sale and purchase transfer transaction has not been paid by the taxpayer, which also result in legal certainty in the transition. In addition there are The sanctions imposed by Article 91 paragraph (1) are in the form of paying fines 7,500,000.00 (seven million five hundred thousand rupiah) for each commit a violation if the signing of the Sale and Purchase Deed is done before PPAT before the parties pay the BPHTB tax. Imposition mechanism BPHTB in the Deed of Sale and Purchase, namely preparing complete documents and data tax object, the taxpayer fills in the information on the tax object and the value of the BPHTB payable into the Tax Deposit Form (SSPD) BPHTB, then calculate the value of BPHTB payable. Next is the Taxpayer and PPAT/Notary sign the SSPD form. The payment process is carried out when the documents SSPD BPHTB which is verified as complete and declared correct. Then payment is made through the beneficiary treasurer or through a bank and must tax receipt of proof of deposit/SSPD BPHTB as proof of payment of BPHTBlegal debt.Keywords: PPAT, Imposition of BPHTB, Deed of Sale and Purchase
GSM and CDMA Based Communication System
Authors: Panday Sarika , Sardey Saurabh
Published: August 2022

Cellular mobile services have been around for a while and are continuously developing today. Numerous communication services, including CDMA and GSM, developed alongside these services. The two most significant technical standards for mobile communication are CDMA and GSM. The GSM and CDMA both transform mobile phone data into radio waves. However, these technologies differ in terms of how calls and data transfer occur through a network. One of the primary distinctions between CDMA and GSM is that CDMA doesn't require a SIM card and instead relies on ESNs to link a mobile phone to its network (Electronic Serial Number).
IR Underwater Wireless Communication: A Review
Authors: Yadav Himani , Seth Sanjeev , Mehra Rekha
Published: August 2022

One of the biggest difficulties in the realm of technology is underwater wireless communication. Due to the increase in the number of vehicles and other equipment being used underwater, which need high bandwidth and consequently large capacity for information transfer, underwater wireless information transfer is of great importance. It was put forth and has gotten the most attention in the past 10 years. Although this field has made successive advancements, there has also been a concurrent constraint, which led to the replacement of acoustics with infrared waves (IR). The light emitting diode that delivers pulsed bursts of IR radiation to the light sending diode inside the second communication module receives the pulsed signal after it has passed through the modulation circuit. A suitable strategy is then chosen for the communication with the least amount of loss and the greatest amount of distance. In this paper, a secure underwater communication method is proposed.
DEEP PECTORAL MYOPATHY IN BROILER CHICKEN OBTAINED FROM SUPERMARKET - CASE REPORT, LITERATURE REVIEW AND PREVENTIVE MEASURES
Authors: Ljubojević Pelić Dragana , Pelić Miloš , Vranešević Jelena , Vidaković Knežević Suzana , Prunić Bojana , Novakov Nikolina , Živkov Baloš Milica
Published: August 2022

The fast growth rates in commercially reared chickens could lead to the changes in their muscle tissue structure and cause breast muscle myopathies, including deep pectoral myopathy (DPM). The incidence of DPM depends on various factors including rearing conditions, age, sex, weight and genetic strain. The aims of the present paper were to report a case of DPM in broiler chickens bought in a supermarket and review important information regarding this disease from the available literature, especially its effect on meat quality parameters and consumer preferences.
THE GLOBAL SPREAD AND EPIDEMIOLOGICAL CHARACTERISTICS OF SALMONELLA SPP, ESCHERICHIA COLI AND METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS (MRSA):RELATED RESEARACH STUDIES IN SERBIA
Authors: Velhner Maja , Milanov Dubravka , Aleksić Nevenka
Published: August 2022

It has been established that some clones of pathogenic bacteria such as Salmonella spp., Escherichia coli ST131, and methicillin-resistant Staphylococcus aureus (MRSA) tend to spread worldwide. Therefore, epidemiological surveys have been conducted to identify the source of infection and to break the chain of infection. In this article, it was pointed out that common international clones of Salmonella are represented with the serotypes Typhimurium, Kentucky, Infantis and Enteritidis. Serovars Typhimurium and Kentucky display multidrug-resistant phenotypes more frequently. Several sequence types of E. coli and the international clone ST131 are described, including clades C1 and C2 with the extended-spectrum cephalosporin-resistance genes (blaCTX-M-15 or blaCTX-M-27). These pathogens are often found in both humans and animals. It is noted that Staphylococcus aureus became resistant to methicillin almost instantly after its introduction into clinical practice. Soon afterwards, MRSA found its way to farm animals and wildlife. The cycles of infection are bidirectional: humans can disseminate MRSA in the environment but animals may also be sources of infection for humans. Comprehensive work has been done by epidemiologists to introduce all necessary measures to eliminate MRSA from hospitals. Also, much effort has been made in MRSA control to prevent infections on animal farms and contamination in the primary food production chain. As the struggle with pathogenic bacteria continues, we face the incessant threat of new resistance and virulence mechanisms, which bacteria use to resist the hostile environment and enhance their survival in their natural habitats including humans and animals. Therefore, the capacity of certain bacteria to spread due to their virulence mechanisms and resistance phenotypes is presented, and a brief description of the research conducted in Serbia is included.
ISOLATION, IDENTIFICATION AND ANTIMICROBIAL PROFILE OF CORYNEBACTERIUM BOVIS FROM SELECTED DAIRY FARM IN BISHOFTU, CENTRAL ETHIOPIA
Authors: Yimana Muhabaw , Bekele Juhar
Published: August 2022

From January to May 2018, a cross-sectional study was undertaken on lactating dairy cows in Bishoftu town to isolate Corynebacterium bovis, determine the prevalence and risk factors, and evaluate the effectiveness of several antibiotics in lactating dairy farms. Study animals were selected randomly from selected dairy farms in the area. Collecting milk samples from mastitic cows, cultivating, and then performing an antibiotic sensitivity test were the procedures followed. A total of 384 lactating dairy cows were examined with inspection and California Mastitis Test (CMT), in which 86 of them were found to be CMT positive. Accordingly, prevalence was 3.9% and 18.5% for cows affected by clinical and subclinical mastitis respectively. The prevalence of mastitis showed statistically significant difference between, lactation stage, breed, age and washing (p > 0.05). However, there was no statistically significant difference noted in animal husbandry practice (p > 0.05). A total of 384 lactating dairy cows were examined with inspection and CMT, in which 86 of them were found to be CMT positive. Out of the 86 mastitis positive samples (sample indicates milk from one cow) sent to microbiology laboratory for microbiological examination, 7 bacterial isolates were identified as Corynebacterium bovis. The biochemical and morphological characteristics of 7 (1.8%) C. bovis isolated from bovine milk samples and the C. bovis reference strains were found to be uniform. Valuable criteria for identification were presence of catalase and oxidase, production of acid from glucose and a requirement for enriched basal media. C. bovis isolates have revealed a higher sensitivity to the kanamycin and streptomycin (71.4% each). A certain resistance has been noted to oxytetracycline (71.4%) and nalidixic acid (42.8%). Higher number of isolates showed moderate sensitivity or resistance to amoxicillin (51.1%). Regarding to multidrug resistance, the study reflects that only one isolate (14.3%) shows multidrug resistance to four drugs namely kanamycin, amoxicillin, nalidixic acid and oxytetracycline. This study demonstrated that mastitis due to C. bovis is rare in lactating dairy farms in Bishoftu. Some of the risk factors for mastitis can be addressed by practical management of dairy cows. Farm owners should selectively use the antibiotics to which the bacteria do not show resistance, such as streptomycin and kanamycin.