bluuebunny/crossref_metadata_2025 huggingface dataset:
Selection of Lentil (Lens culunaris L.) Lines Grown at Different Sowing Dates for Their Precocity and Their Agronomic Performance under Semi-arid Climate of Tunisia
Authors: Ouji A. , Mechri M. , Wassli S. , Shiv K. , Kharrat M.
Published: September 2021

Background: In Tunisia, water deficit and heat stress during the end of cycle are more frequent and causes significant yield losses. Selection of short cycle lines could be a good solution to escape the effect of heat and drought during the end of cycle. Furthermore, there is little published information on the effect of the sowing date on yield and its components in lentils. The aim of this study was to investigate the effect of the sowing date on yield and its components of some lentil lines. The best productive and early lines will be selected and therefore proposed for registration in the official catalog of plant varieties. The availability of these varieties to farmers could increase lentil production. Methods: Sixteen genotypes of lentil out of which 14 were advanced lines and 2 were checks varieties were used in this study. The field experiment was conducted during the 2017-2018 cropping season at Kef research station located in a semi-arid zone in north western Tunisia. Genotypes were sown on December 15th, 2017 and February, 7th, 2018. Seventeen agro-morphological parameters were recorded. Result: Based on agro-morphological analysis, lentil lines exhibited considerable genetic variability. Among the tested lines, L3 line seem to be the earliest lines. It showed high yield as well in timely and late sown dates. This line deserves more attention to develop short-cycle and high yielding variety.
Effect of Some Agronomic Practices on Ascochyta Blight Severity and Yield of Faba Bean (Vicia faba L.) in Tunisia
Authors: Ouji A. , Chekali S. , Rouaissi M.
Published: September 2021

Background: In Tunisia, faba bean (Vicia faba L.) is the first major food legume. The development of faba bean production is facing several biotic constraints. Faba bean Ascochyta blight caused by Ascochyta fabae is one of the most destructive diseases of faba bean and can cause significant yield loss under favorable conditions. As only incomplete resistance ABL varieties are available, some agronomic practices should be applied to control and reduce Ascochyta blight incidence wherever possible. Therefore, this work was undertaken to evaluate the effect of spacing row and seed rate on ABL severity, growth and yield of faba bean. Methods: A split-plot design with three replications was adopted to carry out this study during 2018 and 2019 cropping seasons. ‘Bachaar’ faba bean variety was sown at 40 and 60 cm row spacing and at three seed rates (100, 140 and 200 kg ha-1). ABL severity was assessed visually on a 0-9 scale and agro-morphological traits were measured. Analysis of variance was used to analyze the data. Correlations between agronomic traits, row spacing, seed rate and ABL severity were investigated. Result: Results showed that seed rate has a larger effect on yield than row spacing. In both cropping seasons, the highest grain yield was recorded in 60 cm row spacing and 140 kg ha-1 seed rate treatment. So, this treatment is recommended for obtaining high yield of faba bean. Most of the variation in disease severity was associated with seed rate (r=0.62). The highest ABL score severity was noted at 200 kg ha-1 rate. Over both years, wide row spacing and low seed rate reduced ABL severity. In this study, the small amounts of ABL disease (which reached a score of 5.3 and 4.7 in 2018 and 2019, respectively) had little or no effect on yield.
Paleozoic fossil plants of the north-east of the European part of Russia in the collections of the A. A. Chernov Geological museum
Authors:   Institute of Geology FRC Komi SC UB RAS, Zhdanova L. R.
Published: September 2021

The article is devoted to the history of the study of fossil algae and plants in the Paleozoic sedimentary deposits developed in the north-east of the European part of Russia. The main locations of the fossilized flora in this area are indicated. The history of the study shows that the remains of ancient plants and algae have been studied unevenly, which is due to the nature of the distribution of the remains and their preservation, as well as the lack of specialists. The generalization of the available information made it possible to present a collection of fossil algae and plant remains of the Paleozoic in the A. A. Chernov Geological Museum, which are of scientific and educational interest.
V. A. Dedeev and his role in the development of the resource base of the oil and gas industry of the Timan-Pechora province
Authors:   Institute of Geology FRC Komi SC UB RAS, Timonina N. N. , Maydl T. V. ,   Institute of Geology FRC Komi SC UB RAS, Khabarov A. B. ,   Timan-Pechora branch of State Commission on Reserves
Published: September 2021

The article analyzed organizational and scientific activities of the first head of the Department of Geology of Fuels of the Institute of Geology of the Komi Scientific Center of the Ural Branch of the Russian Academy of Sciences V. A. Dedeev, a well-known scientist in geotectonics and geology of mineral resources. He greatly contributed to the study of the formation conditions and distribution of oil and gas fields, solved problems of their geological, economic and forecasting assessment. His important practical result was the analysis of potential energy resources of the European North of Russia and the north of the Urals and their effective development. We showed V. A. Dedeev’s role in the postgraduate education of young scientists working on studying and expanding the resource base of the oil and gas industry of the Komi Republic and the Nenets Autonomous Okrug. The article summarized V. A. Dedeev’s published and collection materials in various areas.
ANTIMICROBIAL ACTIVITY STUDY OF NEW QUINAZOLIN-4(3H)-ONES AGAINST STAPHYLOCOCCUS AUREUS AND STREPTOCOCCUS PNEUMONIAE
Authors: Samotrueva M. A. , Ozerov A. A. , Starikova A. A. , Gabitova N. M. , Merezhkina D. V. , Tsibizova A. A. , Tyurenkov I. N.
Published: September 2021

Quinazolin-4(3H)-one derivatives exhibiting a wide spectrum of a pharmacological activity, represent a promising class of substances used to obtain antibacterial agents, which is especially important in the context of the emergence of pathogenic microorganisms’ resistance to drugs used in medicine. It has been proved that compounds having a naphthyl radical in the molecule, as well as an amide group bound to the benzene ring as quinazolinone substituents, are characterized by a pronounced antimicrobial activity againstStaphylococcus aureusandStreptococcus pneumoniae.

The aimof the research is a primary microbiological screening of thein vitroantimicrobial activity of new quinazolin-4(3H)-one derivatives againstStaphylococcus aureusandStreptococcus pneumoniae, as well as the assessment of the relationship between the pharmacological effect and the structural transformation of the substance molecule, lipophilicity and the possibility of forming resistance to them.

Materials and methods.The experimental studies have been carried out using well-known nosocomial pathogens of infectious and inflammatory diseasesStaphylococcus aureusandStreptococcus pneumoniaeby a serial dilution method.

Results.A compound containing a naphthyl radical in its structure, which contributes to an increase in the hydrophobicity of the substance and its solubility in the membrane of a bacterial cell, has a bacteriostatic effect against bothStaphylococcus aureusandStreptococcus pneumoniae.A similar pharmacological effect is exhibited by a derivative with an amide group as a substituent of the quinazolinone nucleus linked to a phenyl radical, which probably contributes to an increase in the degree of binding to active sites of enzymes involved in the DNA replication, and protein synthesis. Obviously, the increased lipophilicity, which promotes better binding to the efflux protein, cannot serve as objective characteristics of the emergence possibility of the pathogen’s resistance to this substance.

Conclusion.Among the synthesized compounds, the leading substances that exhibit an antimicrobial activity againstStaphylococcus aureusandStreptococcus pneumonia,have been identified.The assessment of the chemical structure made it possible to substantiate their pharmacological action and draw conclusions about the possibility of developing resistance to it in microbial cells.
Liver transplantation in hepatic cirrhosis: the experience of work of the Federal Siberian research clinical centre
Authors:   Federal Siberian Scientifi c and Clinical Center FMBA of Russia, Kuchkarov M.F. , Dunaevskaya S.S. ,   Krasnoyarsk State Medical University named aft er Professor V. F. Voino-Yasenetsky, Kartashkov E.V. ,   Federal Siberian Scientifi c and Clinical Center FMBA of Russia, Kosik A.A. ,   Krasnoyarsk State Medical University named aft er Professor V. F. Voino-Yasenetsky
Published: September 2021

Prevalence and mortality in terminal stages of diffuse liver diseases amount to 60 %. Foremost, liver transplantation is required by hepatic cirrhosis patients with life expectancy below one year or low quality of life conditioned by the disease. Over the past decade, it has become apparent that only orthotropic liver transplantation is a radical, eff ective and life-saving treatment for hepatic cirrhosis patients. Th is article reports our own results of operative treatment provided for 13 patients using orthotropic liver transplantation advised in relation to diff erent reasons. Th e patients underwent surgery at the surgical department of the Federal Siberian Research Clinical Centre under FMBA of Russia. The earliest outcomes observed during the postoperative period and the structure of complications have been analysed. A clinical case of successful orthotropic liver transplantation is presented. It is postulated that development of this fi eld leads to correction of indications to transplantation and the number of absolute contraindications decreases. Consequently, a possible increase in the number of patients advised to undergo transplantation is to be expected.
Assessment of cytokine and humoral status children with primary Epstein-Barr viral infection, recurrent respiratory infections and adenoviral infection
Authors:   M. Gorki Donetsk national medical university, Makhmutov R.F.
Published: September 2021

Aim of study. To assess the humoral and cytokine status in children with infectious mononucleosis (induced by Epstein-Barr virus), recurrent respiratory infections and adenoviral infection. Material and methods. Indices of humoral (IgА, IgМ and IgG immunoglobulins) and cytokine (IFN-α and IFN-γ interferons, IL-1β and IL-6 interleukins) immunity were evaluated in 93 children with infectious mononucleosis (induced by Epstein-Barr virus (EBV)), 167 children with recurrent respiratory infections of the upper respiratory tract (RRI) and 76 children with adenoviral infection (AI) aged 1 to 18 years as well as 90 children of the same age without diseases associated with lymphoproliferative syndrome and with no medical illnesses exacerbating at the moment of study. Results. A decrease in virus resistance of children with viral infections combined with the lymphoproliferative syndrome was manifested by a 1.5 to 2-fold decrease of IFN-α and IFN-γ. Signifi cantly elevated levels of IL-1β and IL-6 anti-infl ammatory interleukins in children with viral infections combined with the lymphoproliferative syndrome attested to severe progression of the pathological process, predominantly in infectious mononucleosis (induced by EpsteinBarr virus). Results of analysis of cytokines in peripheral blood during infectious diseases may be considered as additional laboratory criteria for differential diagnosis of diseases accompanied by the lymphoproliferative syndrome. Conclusion. While interferons suppress viral replication, investigation of the cytokine status of children with infectious mononucleosis (induced by EpsteinBarr virus), recurrent respiratory infections and adenoviral infection is especially relevant for practical healthcare.
Selection of the optimal type of the stapler cassette for distal pancreas resection
Authors:   Tomsk Regional Oncology Hospital, Drozdov E.S. , Baranov A.I. ,   Russian Medical Academy of Continuing Professional Education, Shkatov D.A. ,   The medical center of G. K. Zherlov, Klokov S.S. ,   The medical center of G. K. Zherlov
Published: September 2021

Aim of study. Investigation of risk factors in development of postoperative pancreatic fi stula (POPF) in patients aft er distal pancreatectomy (DP) involving application of a cutting stapler device (CS) as well as determination of the criteria for selection of the optimal cassette type for such devices making it possible to reduce the POPF development frequency. Material and methods. A two-centre retrospective/prospective controlled study was performed. A total of 46 patients (19 (41.3 %) male and 27 (58.7 %) female) were enrolled. All patients included in the study underwent DP surgery using CS for excision of the pancreas with closure of its stump. In all cases, measurement of the pancreas thickness in the resection area based on the data of preoperative computed tomography and calculation of the difference between the pancreatic parenchymal thickness in the resection area and the staple closure height (SCH). Th e patients were distributed between two groups: 1) without POPF of with biochemical leakage (BL); 2) with clinically relevant POPF (CR-POPF). Results. CR-POPF developed in 15 (32.6 %) cases (type-B POPF: 14 (93.3 %) cases, type-С: 1 (6.7 %) case). Statistically signifi cant diff erence in mean pancreatic parenchymal thickness in the resection area as well as mean SCH between the group without POPF or with BL and the group with CR-POPF (15.4±4.3mm versus 12.3±3.5mm, р=0.01 and 12.8±2.3mm versus 16.4±3.1mm, р<0.01, respectively). Th e frequency of CR-POPF development was reliably lower at the SCH varying from 8 to 14mm (9.5 %) as compared to cases with SCH below 8mm (55.6 %, p<0.01) and above 14mm (50.0 %, p<0.01). Conclusion. Upon analysis of risk factors in POPF development aft er DP, it has been established that a greater pancreatic parenchymal thickness in the resection area as well as SCH are statistically significant risk factors for this complication. Th e optimal SCH making it possible to achieve the minimal frequency of POPF aft er pancreatic stump closure using a CS is within the range of 8-14mm.
Nationwide Access to Endovascular Treatment for Acute Ischemic Stroke in Portugal
Authors: Dias Mariana Carvalho , Dos Reis Ricardo Soares , Santos João Vasco , Nunes Ana Paiva , Ferreira Patricia , Maia Bruno , Fragata Isabel , Reis Joao , Lopes Joana Ramos , Cruz Luis , Santo Gustavo , Machado Egidio , Gabriel Denis , Felgueiras Rui , Dória Hugo Mota , Carneiro Angelo , Correia Manuel , Veloso Luis Miguel , Barros Pedro , Gregorio Tiago , Carvalho Andreia , Ribeiro Manuel , Teotonio Pedro , Neto Lia , E Melo Teresa Pinho , Canhao Patricia , Filipe João Pedro , Moreira Goreti , Azevedo Elsa , Silva Maria Luis , Costa Elisa Campos , Oliveira Guilherme , Pereira Liliana , Neves Ligia , Rodrigues Miguel , Marto João Pedro , Calado Sofia , Grenho Fatima , Branco Gabriel , Baptista Tiago , Rocha Jaime , Ferreira Carla , Pinho Joao , Amorim José Manuel , Araujo José Manuel , Neiva Rui Manuel , Viana João , Lobo Mariana , Freitas Alberto , Cruz Vitor Tedim , Sargento-Freitas João , Lopes José Castro
Published: September 2021

Introduction: Since the publication of endovascular treatment trials and European Stroke Guidelines, Portugal has re-organized stroke healthcare. The nine centers performing endovascular treatment are not equally distributed within the country, which may lead to differential access to endovascular treatment. Our main aim was to perform a descriptive analysis of the main treatment metrics regarding endovascular treatment in mainland Portugal and its administrative districts.Material and Methods: A retrospective national multicentric cohort study was conducted, including all ischemic stroke patients treated with endovascular treatment in mainland Portugal over two years (July 2015 to June 2017). All endovascular treatment centers contributed to an anonymized database. Demographic, stroke-related and procedure-related variables were collected. Crude endovascular treatment rates were calculated per 100 000 inhabitants for mainland Portugal, and each district and endovascular treatment standardized ratios (indirect age-sex standardization) were also calculated. Patient time metrics were computed as the median time between stroke onset, first-door, and puncture.Results: A total of 1625 endovascular treatment procedures were registered. The endovascular treatment rate was 8.27/100 000 inhabitants/year. We found regional heterogeneity in endovascular treatment rates (1.58 to 16.53/100 000/year), with higher rates in districts closer to endovascular treatment centers. When analyzed by district, the median time from stroke onset to puncture ranged from 212 to 432 minutes, reflecting regional heterogeneity.Conclusion: The overall national rate of EVT in the first two years after the organization of EVT-capable centers is one of the highest among European countries, however, significant regional disparities were documented. Moreover, stroke-onset-to-first-door times and in-hospital procedural times in the EVT centers were comparable to those reported in the randomized controlled trials performed in high-volume tertiary hospitals.
Karakteristik Penagihan Secara Bertanggung Jawab Yang Dilakukan Oleh Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi
Authors: Suseno Brahmantyo Aryo
Published: September 2021

AbstractOver time, information technology-based lending and borrowing services emerged. This technology-based money lending and borrowing service is not much different from banks, both of which provide money lending and borrowing services. The difference is the emergence of legal subjects and new legal relationships. To find out the legal subject and legal relations in information technology based lending and borrowing services, researchers conducted legal research with Normative research type. Namely by examining and analyzing applicable laws and regulations, explaining and predicting future developments. This research results in the finding that information technology based lending and borrowing services differ from banks due to new parties called Organizers. In addition, the precautionary principle applied to technology-based lending and borrowing services is not the same. This is because the structure of banks with lending and borrowing services based on information technology is not the same.Keywords: Information Technology-Based Lending and Borrowing Services; Billing; Legal Relationship, Principles in Billing.AbstrakSeiring dengan berjalannya waktu muncul layanan pinjam meminjam uang berbasis teknologi informasi. Layanan pinjam meminjam uang berbasis teknologi ini tidak jauh berbeda dengan bank, dimana keduanya menyediakan jasa pinjam meminjam uang. Hal yang menjadi pembeda ialah munculnya subjek hukum dan hubungan hukum baru. Untuk mengetahui subjek hukum dan hubungan hukum dalam layanan pinjam meminjam uang berbasis teknologi informasi, peneliti melakukan penelitian hukum dengan tipe penelitian Normatif. Yaitu dengan menelaah dan menganalisis peraturan perundang-undangan yang berlaku, menjelaskan dan memprediksi perkembangan yang akan datang. Penelitian ini menghasilkan penemuan bahwa layanan pinjam meminjam uang berbasis teknologi informasi berbeda dari bank dikarenakan adanya pihak baru yang disebut dengan Penyelenggara. Selain itu, prinsip kehati-hatian yang diterapkan pada layanan pinjam meminjam uang berbasis teknologi tidaklah sama. Hal ini dikarenakan struktur bank dangan layanan pinjam meminjam uang berbasis teknologi informasi tidaklah sama. Kata Kunci: Layanan Pinjam Meminjam Uang Berbasis Teknologi Informasi; Penagihan; Hubungan Hukum; Prinsip Dalam Penagihan.
Teachers as a panopticon for smart class students during distance learning
Authors: Rahmawati Eka Rizki , Budirahayu Tuti
Published: September 2021

The education sector is experiencing the impact of the COVID-19 pandemic, resulting in the implementation of the distance learning (PJJ) system to reduce the risk of virus transmission. This system, however, has several obstacles, including the internet network, social inequality, uncertainty in choosing the appropriate learning method, and the decline in student achievement. This problem is also faced by smart class students at Hang Tuah Senior High School 2 of Sidoarjo, forcing its teachers to be able to create innovative learning and act actively to discipline their students. This study aimed to determine the teachers’ role as a panopticon for smart class students during distance learning. The qualitative research method was implemented using Foucault’s genealogical approach and the research informants were determined using the snowball technique. The results of this study reveal that the teachers’ role as a panopticon for the students is carried out with a hierarchical observation, giving reward and punishment, and repeated test system. This study concludes that the role of the teachers as a panopticon during distance learning at Hang Tuah Senior High School 2 of Sidoarjo is particularly useful for disciplining smart class students to carry out their obligations and prevent a decline in academic achievement even though the activities are done virtually.
A Basidiomycete Fungus Responsible for Fresh Mushroom Off-Flavour in Wines: Crustomyces subabruptus, (Bourdot & Galzin) Jülich 1978
Authors: Meistermann Eric , Villaumé Stéphanie , Goffette Delphine , Trarieux Corinne , Coarer Morvan , Roulland Claudie , Dupont Joëlle
Published: September 2021

Grape rot can cause organoleptic deviations in wines, including the aroma of fresh mushrooms; one of the molecules responsible for this is 1-octen-3-one. The bunches affected by this defect are often contaminated by Botrytis cinerea; however, they may also contain a whitish mycelium that cannot be attributed to B. cinerea. This additional fungal growth is the subject of this study.  Several isolations of this fungus were carried out on grape bunches from different vineyards in the French Alsace and Champagne regions using a culture medium containing an anti-Botrytis fungicide (Boscalid). The sequencing of the ITS regions showed that most isolations corresponded to Crustomyces subabruptus (Bourdot & Galzin; Jülich 1978), an endophyte basidiomycete. Contamination tests carried out on bunches and grape juice with this fungus confirmed its responsibility for the appearance of fresh mushroom defects in wines, and showed that it has the capacity to produce large quantities of 1-octen-3-one in a wet and warm environment. The results of this study suggest that this basidiomycete is responsible for fresh mushroom aromas in wines.
LA COLONIZACIÓN TECNOLÓGICA DE LO COTIDIANO
Authors: Muntadas Borja
Published: September 2021

El hecho de pensar la tecnología bajo el prisma de la reticularidad, esto es, de los dispositivos técnicos integrados, nos permite abandonar el paradigma aristotélico del hilemorfismo; es decir, abandonar la idea altamente extendida de que las tecnologías digitales deben entenderse como poco más que simples herramientas que permiten intercambiar datos y coordinar la interacción humana. Cuando uno no se adapta a los procedimientos establecidos y no sigue las reglas de juego, simplemente no está jugando. Dicho así, el tiempo es un dispositivo que conecta uno y otro sistema de acuerdo con un grado de tensión configurando un ecosistema que los integra. Esta extensión temporal toma la forma de la aceleración y la inmediatez. Esta problemática será abordada en este artículo, que se basará en una investigación bibliográfica realizada por el método deductivo.
A CONVENÇÃO SOBRE A PROTEÇÃO E PROMOÇÃO DA DIVERSIDADE DAS EXPRESSÕES CULTURAIS
Authors: Freire Cylviane Maria Cavalcante de Brito Pinheiro , Bessa Leandro
Published: September 2021

Após décadas de discussão sobre como formar um consenso no sentido de derrubar barreiras à legitimação e difusão das diversas manifestações culturais existentes em um mundo multifacetado, surgiu, em nível internacional, no âmbito da UNESCO, um entendimento preponderante reconhecendo a diversidade cultural como característica essencial da humanidade. Tal compreensão foi materializada por meio da Convenção sobre a Proteção e Promoção da Diversidade das Expressões Culturais, ratificada pelo Brasil pelo Decreto Legislativo 485/2006. Objetivou-se, por meio deste artigo, apresentar estudo sobre a concepção da citada Convenção e sua razão de ser, além de expor seus princípios norteadores para, ao final, relatar os reflexos desse instrumento na promoção e proteção da diversidade das expressões culturais no Brasil. A pesquisa foi do tipo bibliográfica e documental, de abordagem qualitativa e finalidade explicativa e descritiva. O método utilizado foi o dedutivo. Os resultados deste trabalho denotam que o Brasil tem muito a contribuir no mosaico de culturas mundial, cuja Convenção serve como uma poderosa ferramenta para um exercício de resistência em oposição à massificação da cultura ditada pelos países desenvolvidos.
Development of a strategy induction AOX1 promoter methylotrophic yeast Komagataella phaffii
Authors: Bytyak D. S. , Korneeva O. S. , Motina E. A.
Published: September 2021

Currently, there is a significant increase in interest in the industrial production of enzyme preparations (and other recombinant proteins) using various microorganisms, including methylotrophic yeasts such as Komagataella phaffii. At the same time, the most significant productivity of the target proteins is achieved by methanol induction of heterologous genes cloned under the control of the AOX1 promoter. Thus, the efficiency of biosynthesis is largely determined by the metabolism of methanol. In this connection, the aim of the work is to develop an optimal strategy for methanol induction of the AOX1 promoter of Komagataella phaffii. The object of the study is the culture of the recombinant phospholipase A2 producing strain Komagataella phaffii. The studies were carried out in a laboratory fermenter Infors Minifors (Switzerland) on a liquid nutrient medium BSM (Basal Salt Medium) We used the generally accepted methods of studying the characteristics of metabolic activity, including the calculation of specific characteristics and productivity of the strain. The result of the study is the determination of the specific rate of consumption of methanol used as a carbon source, which was 19.2±1.8 mg/g*h. Also, the specific growth rate of Komagataella phaffii was determined and amounted to 0.24 h-1.Based on the data obtained during the research, a strategy for the induction of the AOX1 promoter in the cultivation of the methylotrophic yeast Komagataella phaffii was developed by maintaining the methanol concentration in the range of 0.6 to 2% based on the concentration of dissolved oxygen in the medium. The developed strategy of induction of the AOX1 promoter made it possible to obtain at least 1.87 g / l of recombinant protein (phospholipase A2) during cultivation of Komagataella phaffii for 96 h, which is 3.7 times higher than the known results.
Scientific approaches to the application of red-and-white cows milk in the production of combined composition soft cheeses
Authors: Derkanosova A. A. , Kurchaeva E. E. , Vostroilov A. V. , Bazhenova E. V. , Popova Y. A. , Matvienko N. A.
Published: September 2021

The demand for natural products is constantly growing in the current environmental situation. This encourages manufacturers to increase the production of these goods. However, almost all branches of the food industry use nowadays a large number of biologically active additives, mainly of synthetic origin. In this regard, the introduction of natural vegetable supplements in the composition of a traditional food product will contribute not only to an increase in the nutritional and biological value of the product, but also to expand the range of healthy food products. The possibility of using dietary fiber from root crops of scorzonera, immobilized on biopolymers, and chickpea flour obtained from chickpea beans bioactivated by germination in the amount of 5% and 15%, respectively, was studied in the work. Scientific substantiation of the effectiveness of the use of vegetable filler in the production of combined soft cheese was given. The cheese product produced has a mass fraction of fat in dry matter of 4.5%, a mass fraction of moisture not more than 64%, a mass fraction of salt not more than 2.0%. The use of dietary fiber as a food additive in cheese production gives the product a functional value. Dietary fiber, introduced in an amount of 5.0%, increases the yield of the finished product by 11-11.5%. Thus, applying the proposed technology for the production of a soft cheese product, it becomes possible to solve a number of technological, environmental and economic problems, including an increase in the nutritional value of a soft cheese product, due to enrichment with dietary fiber, macro- and micronutrients, as well as an increase in the biological value of the developed product by balancing the amino acid composition
Modern assessment of bakery properties of Russian wheat
Authors: Meleshkina E. P. , Kolomiets S. N. , Zhiltsova N. S. , Bundina O. I.
Published: September 2021

The paper presents an analysis of the quality of soft wheat grown in different soil and climatic conditions of the Russian Federation and having a wide range of quality indicators (the amount of gluten - from 15.3 to 29.4%, the quality of gluten - from 29 to 84 units. IIR, falling number - from 134 to 475 sec). Revealed significant differences in the quality of modern Russian wheat from the wheat of the late XX century. The interrelationships of indicators of quality of grain, flour obtained from it, rheological properties of dough with indicators of quality of bread on a modern instrument base using an alveograph, valorigraph and mixolab have been established. The study of the rheological properties of the dough on the mixolab was carried out in the classical "Chopin Wheat +" mode. According to the profiler parameters (radial diagram), it was found that the analyze grain was characterized by increased rates of starch retrogradation, which characterizes the carbohydrate-amylase complex of flour, a high water absorption index, and increased amylolytic activity; low viscosity and gluten +. To differentiate the strength of wheat, a test laboratory baking of bread was carried out using two methods - the remix method and the reduced-remix method, which showed that the most stable relationships were revealed when baking bread with the remix method. When baking with the abbreviated method, higher indicators of bread quality were obtained, but there are fewer stable relationships, moreover, both for wheat containing less than 25% gluten and more than 25%.
Study of the structural and mechanical properties of biopolymers in order to obtain a capsule-type product
Authors: Sokolov A. Y. , Shishkina D. I.
Published: September 2021

The article presents some theoretical and experimental data on promising technologies, namely, the processes of obtaining artificial food materials such as spheres or "caviar". They are derived from molecular processes: solubilization, spherification, etc. Possible applications are the food industry, the food service industry, biotechnology, and others. There are different features of obtaining artificial products based on alginates. The peculiarities of the alginate structuring are that it is possible to form a gel layer-encapsulation and gel formation over the entire thickness of the product due to the special chemical properties of the fixing salt. Based on the theory of the molecular structure of biopolymers, molecular technologies for the synthesis of artificial food products were developed, using the example of molecular "caviar". As a result of our own experiments, we obtained a satisfactory encapsulated product from a biopolymer crosslinked with Ca2+ salts in terms of organoleptic and physico-chemical properties. The colloidal biopolymer solution for forming "eggs" was characterized using the method of rotational viscometry, which showed the features of the sodium alginate solution as a structured thixotropic material, which is characterized by" difficulty " of shear at low speeds of rotation of the viscometer rotor. Further on the rheogram, such material exhibits a predicted relatively stable flow. As a result, it can be used to produce semi-finished products of a given shape and texture as a food semi-finished product or product. If the technology is refined, it is possible to use colloidal systems based on alginates and other biopolymers in biotechnology, including the cultivation of microorganisms of various taxonomic groups.
The effect of starter on amino acid composition of fermented milk
Authors: Zandanova T. N. , Ivanova K. V. , Myryuanova T. P.
Published: September 2021

The experimental studies of the amino acid composition of the skimmed cow milk fermented with kefir corns, natural kurunga symbiotic starter and bacterial concentrate of the microbial consortium (BСMC) have been carried out. The bacterial concentrate of the microbial consortium is intended for the preparation of a fermented milk beverage of mixed fermentation – kurunga. The microbial consortium obtained by autoselection of population of kefir corn starter and thermophilic lactobacteriums Lactobacillus bulgaricus and Lactobacillus acidophilum has been used to prepare BCMC. The amino acid analysis of the samples has been carried out by IC method with postcolumn derivatization of amino acids ninhydrin in the acid hydrolyzate of the sample on INGOSAAA-400 amino acid analyzer. The most of essential amino acids has been found in kefir – 434 mg/g of protein. In the samples prepared with natural starter and bacterial concentrate, the total amount of essential amino acids has been 401.84 and 403.8 mg/g of protein, respectively. Exogenous amino acids are essential for the growth of lactics and yeast. The difference in the total amount of the essential amino acids in the samples, probably, caused by the proteolytic activity of the starters and the growth requirements of the microorganisms. The assessment of the bioavailability has been carried out by the method of I.A. Rogov and N.N. Lipatov according to the coefficients of differences between the amino-acid score (CDAS) and bioavailability. The amino-acid scoring studies have shown that the protein in the studied samples is characterized by a complete composition. According to bioavailability, the kurunga samples exceeded kefir by 0.55-0.75%. The obtained results indicate that according to the biochemical activity, the bacterial concentrate of the microbial consortium is practically identical to kurunga prepared with natural starter. It makes possible to obtain a product bioavailably identical to a traditional beverage.
Social security of the region and directions of its provision
Authors: Gorkovenko E. V. , Platonova I. V.
Published: September 2021

Regional social policy often acts as the activity of the subject in the person of federal authorities and public organizations. The main goal of such a policy is to achieve equal living conditions, developed infrastructure and social structures of the region. And the general coordination of state, regional and local interests is actually implemented with great difficulty and is very often replaced by centralized management. Since regions and subjects become targeted objects of federal authorities, regions are not always able to realize their own interests. To avoid this situation, the regions need to establish their independence in solving social problems. Currently, the social and economic development of the state directly depends on the level of development of the regions. The concept of "economic security" and "social security" are closely related to each other, since the economic security of both the country and the regions mainly consists of socio-economic indicators. In other words, the economic security of the state and its subjects depends on the level of their social security. As a result of the conducted research, threats to the economic (including social) security of the region were identified. The assessment of the level of social security of the regions that are part of the Central Black Earth Economic Region was carried out using the methodology of Gaifullin A. Yu.and Gaifullina M.M. (Institute of Socio-Economic Research), which showed a fairly high level of social security of the object under study – the Voronezh Region. Determined the effectiveness of regional social policy and the ways and measures to improve the social policy of the region, in particular, it is recommended to pay attention to demographic component of the social security, living standards of the population, education and culture, and strengthen the rule of law.
Comprehensive integral assessment of resource availability of an industrial enterprise at different stages of its life cycle
Authors: Krivtsova N. N. , Salikov Y. A. , Reznikova E. A. , Karpovich M. A.
Published: September 2021

The need to assess the resource availability of the industrial enterprise at each stage of the life cycle is due to the limited resources available and the increase of their effective and rational use. The development of a methodical approach to assess the resource availability of the industrial enterprise will allow not only to diagnose the problems that have arisen or may arise at a particular stage of its life cycle, but also to anticipate changes in the market situation and respond in a timely manner. Resource provision is a set of necessary types of resources that an industrial enterprise has and uses them rationally in order to extend or restore the appropriate stage of the life cycle and further development. For industrial enterprises, the highest priority are such components of the resource provision of activities by stages of the life cycle as: "Financial and information-intellectual resources" at the stage of birth, "Personnel and production and sales resources" at the stage of growth, "Image resources and resources of economic security" at the stage of maturity and "Resources of economic security and information-intellectual resources" at the stage of crisis. On the basis of the presented priority components of the resource provision of the industrial enterprise the system of indicators, allowing to measure and control the process of its development at each stage of the life cycle, was formed. The developed methodology of assessing the resource availability of the industrial enterprise at various stages of its life cycle includes 7 stages. According to the presented methodological approach, the assessment of resource availability of actually operating industrial enterprise at various stages of its life cycle was carried out. The meat-processing enterprise of the Voronezh region (LLC "X") was chosen as the one under study. The resulting value of the integrated integral indicator of resource availability of the industrial enterprise under study at the stage of birth corresponds to a very high level, at the stage of growth - to the average and at the stage of maturity - very low, which indicates the lack of priority components of resource provision to overcome the growth stage and the transition to the stage of maturity. Based on the assessment of resource availability the possible directions for the further development of "X" LLC were proposed.
Simulation of the growth of sucrose crystals in a sugar-containing solution
Authors: Semenov E. V. , Slavyansky A. A. , Gribkova V. A. , Мitroshina D. P. , Antipov S. T.
Published: September 2021

Crystallization is one of the most important steps in the technological flow of commodity sugar. By its nature, it develops in a fairly wide temperature range, conditions of varying concentration of the solution, its peptization and other mass-exchange process of formation and growth of sugar crystals in a sugar solution by diffusion transfer in it sucrose molecules. To this it is necessary to add such complicating physical and mathematical formalization phenomena, affecting crystallization, such as the shape of the crystal, purity, viscous properties and surface tension of the solution, the presence of non-sugars, etc. Therefore, among the factors that determine the whole process, the factors usually take place, keeping among them only priority and most important from the point of view of the study. The article, unlike known analogues, provides justification and quantitative analysis of the kinetics of the sucrose crystallization process, taking into account the features of the crystal shape and diffusion properties of the solution. From the point of view of classical diffusion theory, the phenomenon of crystallization is interpreted as molecular with infinite rate of perilation from the source of diffusion transfer in the solution of sucrose molecules, so that the concentration in the sugar-containing liquid system is also supposed to change instantly at each point. However, since in the real world this effect is not observed, in order to resolve this contradiction, introduce the concepts of the indignant and unperturbed, separated by the diffusion front of the concentration of the regions of these phase states. Using the kinematic characteristics of the front, determine the time of the crystallization process in general in both phases. This allows us to calculate the processing period of the solution with greater accuracy than the results obtained on the basis of classical theory.
On Tribonacci Functions and Gaussian Tribonacci Functions
Authors: Soykan Yüksel , Göcen Melih , Okumuş İnci
Published: September 2021

In this work, Gaussian Tribonacci functions are defined and investigated on the set of real numbers $\mathbb{R},$ \textit{i.e}., functions $f_{G}$ $:$ $\mathbb{R}\rightarrow \mathbb{C}$ such that for all $% x\in \mathbb{R},$ $n\in \mathbb{Z},$ $f_{G}(x+n)=f(x+n)+if(x+n-1)$ where $f$ $:$ $\mathbb{R}\rightarrow \mathbb{R}$ is a Tribonacci function which is given as $f(x+3)=f(x+2)+f(x+1)+f(x)$ for all $x\in \mathbb{R}$. Then the concept of Gaussian Tribonacci functions by using the concept of $f$-even and $f$-odd functions is developed. Also, we present linear sum formulas of Gaussian Tribonacci functions. Moreover, it is showed that if $f_{G}$ is a Gaussian Tribonacci function with Tribonacci function $f$, then $% \lim\limits_{x\rightarrow \infty }\frac{f_{G}(x+1)}{f_{G}(x)}=\alpha \ $and\ $\lim\limits_{x\rightarrow \infty }\frac{f_{G}(x)}{f(x)}=\alpha +i,$ where $% \alpha $ is the positive real root of equation $x^{3}-x^{2}-x-1=0$ for which $\alpha >1$. Finally, matrix formulations of Tribonacci functions and Gaussian Tribonacci functions are given. In the literature, there are several studies on the functions of linear recurrent sequences such as Fibonacci functions and Tribonacci functions. However, there are no study on Gaussian functions of linear recurrent sequences such as Gaussian Tribonacci and Gaussian Tetranacci functions and they are waiting for the investigating. We also present linear sum formulas and matrix formulations of Tribonacci functions which have not been studied in the literature.
Analisis Hubungan Laba Akuntansi dan Komponen Arus Kas Dengan Harga Saham
Authors: Fitri Nurani  , Andrianto
Published: September 2021

This study aims to examine the relationship between accounting profit, operating cash flow, investment cash flow and financing cash flow with stock prices. This study uses data from the financial statements of companies listed in LQ 45 on the Indonesian Stock Exchange from 2014- 2019. And the company sampling technique using purposive sampling a number of 34 companies LQ45 in 2014-2019. The research sample was tested using Pearson Correlations analysis and normality test and linearity test. The results of the Pearson Correlations correlation analysis show that the variables of accounting earnings and funding cash flows have a relationship with stock prices with a significance value of <0.05. And the operating cash flow and investment cash flow variables have no relationship with stock prices with a significance value of ≥ 0.05
The Activities Of Combination Citrus hystrix Peel Extract and Carica papaya Leaves Extract Against Candida albicans and Escherichia coli
Authors: Anitasari Septarini Dian , Sari Dwi Nur Rikhma
Published: September 2021

Citrus hystrix Peel Extract and Carica papaya Leaves Extract contain several active components that can be used as antimicrobial compounds. The aim was to test a mixture of extracts from Citrus hystrix peel and Carica papaya leaves as growth inhibiting compounds for Candida albicans and Escherichia coli. This study used 4 levels of treatment, namely a combination of papaya leaves extract and orange fruit peel at concentrations of 0%, 25%, 50%, 75% and 100%. The research data were in the form of the diameter of the growth inhibition of Escherichia coli and Candida fungi, which were analyzed using the Kruskall-Wallis test at 5% confidence level and 5% Duncan's test. showed a significant difference between treatments, but the concentration of 100% showed better results to inhibit Escherichia coli (1.58 ± 0.28 d) and the growth of Candida albicans (1.53 ± 0.57b) compared to controls and other concentrations.
Phytochemical Screening of White Turi (Sesbania grandiflora (L.) Pers.) Leaves Extract in Various Extraction Methods
Authors: Rohmah Jamilatur , Saidi Ida Agustini , Rofidah Luthfiyah , Novitasari Fia , Margareta Frida Amelia
Published: September 2021

One of the Fabaceae family that has potential as medicinal plant is the white Turi plant (Sesbania grandiflora (L.) Pers.).The purpose of this study was to determine the content of secondary metabolites which can be extracted using a various extraction methods.The extraction method used are digestion, percolation, reflux, soxhlet, infusion, and decoction extraction. The Turi plants used come from Mojosari, Mojokerto.The results of the initial phytochemical screening of white Turi leaf extract (Sesbania grandiflora (L.) Pers.) Were extracts in six extraction methods containing alkaloids, saponins and tannins.In extracts using the digestion, soxhlet, and reflux method containing steroids.Meanwhile, the four extracts from the digestion, percolation, soxhlet, and reflux methods contain phenolic.And the infusion and decoction method extracts containing flavonoids and triterpenoids. The similarity of the phytochemical test results for each extract but with different intensity results.
Efficacy of Aloe vera Gel on the Excision Wound Healing in Sprague dawley Rats
Authors: Palgunadi Bagus Uda , Rahayu Asih , Prakoso Yos Adi
Published: September 2021

Wound is a pathological processes in all living things. Wound includes the overlapping mechanisms. The failure in wound healing causes infection. This study aimed to analyze the efficacy of Aloe vera gel in excisionwound on the rat’s back. This study used 18 male, Sprague Dawley rats, and they were induced excision wound on the back. The rats were separated into 3 groups, K1 = control, K2 = treated with betadin gel, K3 = treated with Aloe vera gel. The therapy was given twice a day for 7 days. The wound measurement was observed in day 3 and 7. The data were analyzed using SPSS. The result showed that Aloe vera gel potentially promote wound healing through the decrease microscopical condition of wound, re-epithelialization, and deposition of collagen better than in group K1 and K2 (p≤0.05). In conclusion, Aloe vera gel promote excision wound healing in Sprague Dawley rats.