bluuebunny/crossref_metadata_2025 huggingface dataset:
Germinação e vigor de sementes de Mimosa tenuiflora após o armazenamento
Authors: Silva Joyce Naiara da , Silva Monalisa Alves Diniz da , Moura Débora Purcina de , Rodrigues Marília Batista Silva , Alves Rafael Mateus , Silva Elania Freire da
Published: October 2022

A Caatinga é um bioma exclusivo do Brasil em que cerca de 80% da sua área já foi modificada. Dessa forma há a necessidade de cada vez mais estudar as espécies vegetais que tenham potencial para a regeneração dessas áreas degradadas. Objetivou-se acompanhar o desempenho fisiológico de sementes de Mimosa tenuiflora, submetidas a tratamentos de superação de dormência após diferentes períodos e condições de armazenamento. Empregou-se o delineamento experimental inteiramente casualizado, com quatro tratamentos pré-germinativos de superação de dormência (testemunha, imersão em ácido sulfúrico por 10 e 13 min. e imersão em soda cáustica 20% por 30 min.), após quatro períodos de armazenamento (0; 50; 100; e 150 dias) em ambiente com e sem refrigeração, adotando-se um esquema fatorial 4 x 4 x 2. Determinou-se antes e após cada período de armazenamento as seguintes avaliações: teor de água, porcentagem, índice de velocidade e tempo médio de germinação, porcentagem, índice de velocidade e tempo médio de emergência, comprimento da parte aérea e do sistema radicular e condutividade elétrica das sementes. A utilização do ácido sulfúrico foi eficiente na superação da dormência das sementes de M. tenuiflora, mantendo os valores máximos ao longo dos períodos de armazenamento. A utilização da soda cáustica por 30 min. só é recomendada no início do armazenamento, sendo que a partir de 50 dias há redução do potencial fisiológico das sementes.
Justiça Multinível e a de Transição: Reparação Integral e a Revolução Legislativa da Lei de Anistia do Brasil
Authors: Amaral Maria Fernanda de Toledo Pennacchi Tibiriçá , Tibiriçá Amaral Sérgio
Published: October 2022

O presente trabalho tem o intuito de avaliar a responsabilidade civil do Estado brasileiro nos casos da Guerrilha do Araguaia e Vladmir Herzog. Embora em ambos os casos o Brasil tenha sido condenado tanto no âmbito interno, pelo STF, como em âmbito internacional, pela Corte Interamericana, essa sentença não se efetivou. Isso porque a Corte determinou a revogação da lei de anistia, o que não foi acatado pelo Estado brasileiro. Desse modo, todos os que cometeram crimes durante a ditadura militar foram “perdoados” em razão dessa lei, o que impede a reparação integral e efetiva dos danos.
Criação de valor compartilhado e impacto social: estudo de caso em instituição financeira
Authors: Lunkes Fernando , Lazzarotto Emerson
Published: October 2022

A criação de valor compartilhado pode ser definida como práticas e políticas operacionais que aumentam a competitividade de determinada empresa e ao mesmo tempo podem melhorar as condições socioeconômicas nas comunidades onde a empresa atua e opera gerando impacto social positivo. No segmento de instituições financeiras, as cooperativas de crédito se destacam por gerenciar atividades que alinham seus negócios ao atendimento de usuários, compartilhando valores para os cooperados. Assim, o objetivo deste estudo é analisar como uma instituição financeira promove a criação de valor compartilhado por meio de ações realizadas nos últimos três anos. Trata-se de uma pesquisa qualitativa e descritiva, abordada por meio de um estudo de caso único. Os resultados apontaram que a empresa analisada em questão tem conseguido alinhar a prática da criação de valor compartilhado às suas estratégias empresariais e que é possível promover a sustentabilidade e a perenidade dos negócios ao mesmo tempo em que é criado e compartilhado valor social e ambiental.
Avaliação de características morfométricas da bacia hidrográfica do Rio Peruípe (BA)
Authors: Santos Joice de Jesus , D'Esquivel Kelly Silva
Published: October 2022

O presente estudo tem como objetivo determinar as características morfométricas da bacia hidrográfica do rio Peruípe, usando o (SIG), por meio do software ArcGIS 10.8©. É de grande importância obter e avaliar as características fisiográficas da bacia para um gerenciamento dos recursos hídricos de forma eficiente. Assim, de posse da delimitação da bacia foram obtidas características morfométricas como a área de drenagem, o perímetro, o comprimento total dos cursos d’água e do rio principal, que foram obtidos por meio do ArcGIS©. Foram calculadas também a densidade de drenagem, o coeficiente de compacidade, o fator de forma, o índice de circularidade, o coeficiente de manutenção e a declividade média da bacia. Após a avaliação das características, apurou-se que a bacia do rio Peruípe é uma bacia alongada e em condições naturais; constatou-se que a mesma apresenta baixa susceptibilidade a enchentes.
Fatores associados ao tempo entre o diagnóstico e o início do tratamento do câncer infantojuvenil
Authors: Silva Victor Borges da , Lucena Nyellisonn Nando Nóbrega de , Pinto Rayssa Naftaly Muniz , Serpa Eliane Batista de Medeiros , Sousa Simone Alves de , Valença Ana Maria Gondim
Published: October 2022

Objetivou-se analisar a distribuição do câncer infantojuvenil e identificar fatores associados ao atraso no início do tratamento oncológico, na Paraíba, a partir dos Registros Hospitalares de Câncer, de 2010 a 2018. Estudo observacional, descritivo e analítico, com 896 registros de crianças e adolescentes (0-19 anos), identificando-se características epidemiológicas, clínicas e o cumprimento da Lei Federal 12.732/12 (lei dos 60 dias para início do tratamento). Os dados foram analisados pela regressão logística (α=5%). Constatou-se que 80,2% dos pacientes iniciaram o tratamento no tempo previsto por lei (≤ 60 dias). Observou-se que indivíduos de 10 a 19 anos, com tumores sólidos, submetidos à cirurgia e tratados em um dos quatro RHC’s da Paraíba apresentam maiores chances de terem a terapia antineoplásica iniciada em um tempo superior a 60 dias. Conclui-se que o atraso no início do tratamento contra o câncer infantojuvenil está associado a características epidemiológicas e clínicas dos pacientes oncológicos pediátricos.
Fatores relacionados ao risco de feridas em pacientes com Diabetes mellitus Tipo 2
Authors: Barbosa da Rocha Rebeca , Sales da Silva Cristiano , Dos Santos Cristiana Maria , Silveira Pedro Renan de Souza Lima da , Sousa Geice Pereira de , Fontenele Maria Karliane Arruda , Cardoso Vinicius Saura
Published: October 2022

Poucos estudos abordam as características sociodemográficas e o risco de feridas no nordeste brasileiro. O objetivo do estudo foi determinar a prevalência de risco de feridas e os fatores relacionados em pessoas com diabetes no município de Parnaíba, estado do Piauí, Brasil. Estudo transversal realizado com 300 pessoas com diabetes. Os voluntários foram avaliados por meio de questionário sociodemográfico, monofilamento de 10 g, diapasão de 128 Hz, martelo de reflexo e escala de classificação de risco de feridas. Sexo masculino (OR 2,33; IC 95% 1,22-4,42), idade (OR 1,03; IC 95% 1,01-1,05), inatividade física (OR 2,35; IC 95% 1,26-4,38) e duração maior de diabetes (OR 3,28; IC 95% 1,56-6,91) foram associados ao risco de feridas. Este estudo demonstrou um alto risco de feridas relacionado a idade, sexo feminino, duração da diabetes e inatividade física e alta prevalência de complicações como a neuropatia periférica diabética e amputações.
Genetic diversity of barley accessions from Mongolia for greenbug resistance
Authors: Radchenko Evgeny E. , Abdullaev Renat A. , Akimova Daria E. , Zajtseva Irina Yu.
Published: October 2022

BACKGROUND: Significant damage to barley crops in the southern regions of the Russian Federation is caused by the greenbug Schizaphis graminum Rondani. Cultivation of resistant varieties is a cheap, efficient and environmentally friendly way to combat the phytophage. The specificity of relations between S. graminum and barley is shown, that determines the need to broad the genetic diversity of cultivated varieties.
AIM: The study of effectiveness and genetic control of the greenbug resistance in barley accessions from Mongolia.
MATERIALS AND METHODS: We studied 175 barley landraces from Mongolia for resistance to the Krasnodar aphid population. We assessed damage to resistant lines selected from heterogeneous accessions k-3885, k-3904, and k-4080, as well as the variety Post (a carrier of the previously identified Rsg1 gene) by 86 aphid clones isolated from the population. Under laboratory conditions, the aphid resistance segregation of F2 hybrids was analyzed from crossing three accessions from Mongolia with a susceptible tester.
RESULTS: Five heterogeneous accessions were identified, in which plants with high resistance to the pest were found; in 28 accessions, damage to the leaf surface of the resistant component varied from 31% to 60%. As a result of the assessment of the resistance of four barley accessions to S. graminum clones, 15 virulence phenotypes were identified. Accessions k-3885, k-3904 and k-4080 each have one dominant resistance allele, which differ from each other and differ from Rsg1.
CONCLUSIONS: The genetic diversity of barley accessions from Mongolia in terms of greenbug resistance is low. The genotypes of S. graminum differentially interact not only with the major, but also with weakly manifested barley resistance genes.
Search for SNP markers of stress tolerance in the TaDREB1 and TaWRKY19 genes of bread wheat in the Cis-Ural steppe zone
Authors: Zaikina Evgeniya A. , Ismagilov Kamil R. , Kuluev Bulat R.
Published: October 2022

BACKGROUND: Under the conditions of the Cis-Ural steppe zone, abiotic stress factors such as winter conditions and drought have a negative impact on the yield of bread wheat (Triticum aestivum L.). However, the efficiency of breeding to these stress factors is limited by wide variations depending on the weather conditions in different years. To collect stress-resistant forms in the selected material, genomic selection can be used, however, SNP markers of drought tolerance and winter hardiness of bread wheat, unique to this region, are unknown.
AIM: The purpose of this study is to identify SNP markers in the genes of the key transcription factors of bread wheat TaDREB1 and TaWRKY19, which are involved in the regulation of plant resistance to abiotic stresses.
MATERIALS AND METHODS: 16 varieties and lines of bread wheat were analyzed, contrasting in terms of winter hardiness and drought tolerance. DNA from wheat leaves was isolated by the standard CTAB method. Primers were selected, fragments of open reading frames of the studied genes were amplified, and nucleotide sequences were determined by automatic capillary sequencing.
RESULTS: Among the analyzed bread wheat varieties and lines, 12 SNPs in the TaDREB1 gene and 5 SNPs in TaWRKY19 were found.
CONCLUSIONS: The results of statistical analysis showed that substitution 866 T/A in the TaDREB1 gene is associated with winter hardiness, while substitution 587 A/G in the TaWRKY19 gene is associated with winter hardiness and drought resistance.
The use of R-nj, B1, Pl1 genes to improve marker properties in the selection of maize haploinducers
Authors: Liu Xinfang , Ulyanov Alexey V. , Khatefov Eduard B.
Published: October 2022

BACKGROUND: Studies were carried out on the creation of haploinductor lines using various methods for testing haploinductor and marker ability from the VIR maize genetic collection, adapted to the conditions of the Liaoning province in China and the South of Russia.
MATERIALS AND METHODS: On 22 maize testers, studies were carried out on the creation of haploinductor lines and testing the haploinductor and marker ability by the test-cross method. Sources of R1-nj, B1, Pl1 genes from the VIR maize genetic collection were used.
RESULTS: The lines of maize haploinducers Liaoyu No. 1, Liaoyu No. 2, Liaoyu No. 3 and Liaoyu No. 4 were created with a haploinduction frequency of 6.85%, 7.53%, 6.66% and 6.03%. respectively, with a high quality of labeling with the R1-nj, B1, Pl1 genes in test crosses.
CONCLUSIONS: In the process of selection of haploid maize on the basis of genes A, haploinductor lines with a high frequency of haploinduction and high efficiency of markers in test crosses, abundant pollen and grain productivity, resistance to late blight and lodging, and adaptation to the agroclimatic zone of Shenyang Province (China) were obtained and the North Caucasian Federal District (Russia).
Influence of air humidity on variability of morphological features of Vigna unguiculata (L.) Walp. in artificial conditions
Authors: Krylova Ekaterina A. , Khlestkina Elena K. , Burlyaeva Marina O.
Published: October 2022

Vigna unguiculata (cowpea) is a species widely cultivated in southern countries, it occupies the third place in the world in terms of cultivation area among leguminous crops. Cowpea is distinguished by its resistance to drought and infertile lands, productivity, nutritional value and excellent culinary qualities of pods and seeds. In recent years interest in vegetable varieties of cowpea has increased in Russia. It is necessary the creation of new varieties that adapted to cultivation in different regions and suitable for mechanized cultivation. The type of stem growth habit is one of important signs in the selection of modern cowpea varieties. Knowledge of variability and stability of this feature and its interrelationships with other morphological features is necessary for the effective implementation of culture breeding programs.
4 cowpea samples with different growth types were the material in this study. The plants were grown in contrast air humidity conditions at 60% and 90%. At total 14 morphological features were analyzed in 110 plants. The analysis revealed the significant influence of air humidity on the variability of the length and width of the first leaf. It was shown influence of humidity on the ability of plants to form a climbing shoot. The variability of length of the second internode, the pod length and the width of the middle leaflet was depended on the individual characteristics of the genotype. The variation in plant length was due to a complex of factors and it was interrelated with growth conditions and genotypic characteristics. In addition, an unidentifiable effect of air humidity on the growth habit type of different samples was revealed.
The efficiency of molecular markers of the SKr suppressor gene that determines the crossability of common wheat with rye
Authors: Porotnikov Igor V. , Puykkenen Valentina P. , Antonova Olga Yu. , Mitrofanova Olga P.
Published: October 2022

BACKGROUND: Among the genes involved in the control of crossing between common wheat and rye, the dominant suppressor SKr (Suppressor of crossability) having the major effect on inhibiting crossability is the most studied. DNA-markers have been developed for this gene. There are cases of successful application of some of them in wheat breeding, but there is practically no information about their diagnostic efficiency in screening of ex situ collections.
MATERIALS AND METHODS: To evaluate the effectiveness of SKr markers Xcfb341, TGlc2, gene12 и gene13 to identify forms with high crossability with rye, we studied 103 bread wheat accessions from the VIR collection with different seed set (093%) after pollinated with rye.
RESULTS: Efficiency in detection crossable forms (upper 15%) was demonstrated by markers Xcfb341, TGlc2 and gene12. No significant allele-trait association was found for gene13 marker. Ten haplotypes were identified based on four markers. Five haplotypes were revealed for accessions from China, while two of them were associated with high crossability. Eleven accessions including the line L6-HSR were heterogenic in markers. For this line the relationship of diagnostic fragments with the crossability level observed in the field has been experimentally confirmed.
CONCLUSIONS: The SKr gene markers studied can be used for accessions searching at ex situ collections that potentially have high crossability with rye, for controlling the retention of recessive skr alleles when regenerating seed accessions, as well as in breeding programs.
Modern investigations of plant genetic resources. Development of scientific schools and guidelines founded by N.I. Vavilov
Authors: Khlestkina Elena K.
Published: October 2022

The issue No. 3 of the journal Ecological Genetics is dedicated to the 135th anniversary of Academician Nikolai Ivanovich Vavilov, which is celebrated on November 25, 2022. N.I. Vavilov laid the foundations for systematic work with the world collections of cultivated plants and their wild relatives. To carry out large-scale work on the study of plant genetic resources, N.I. Vavilov attracted geneticists, biochemists, and physiologists to the institute he created. A distinctive feature of the extensive large-scale and complex studies of the VIR gene pool were the approaches that allowed generalizations of the observations made in the light of hereditary variability. The fundamental works of Vavilov and his associates in the direction of complex research of cultivated plants allowed to make cardinal transformations in the entire scientific and production chain collectionprebeedingbeedingseed productionproduction. This issue presents a cross-section of modern works in the field of the study of plant genetic resources, which demonstrates the continuity and development at a new level of the directions founded by N.I. Vavilov and his associates.
The effect of hydrochloric, malic and succinic salts of 2-ethyl-6-methyl-3-oxypyridine on ­self-­assessment of depression manifestations in women receiving radiotherapy after surgical ­treatment of uterine cancer
Authors: Volchegorskii Ilya A. , Vazhenin Andrey V. , Alekseeva Anna P.
Published: October 2022

Background. The detection of cancer and its subsequent treatment contribute to the development of depression. This circumstance illustrates the need for proactive prevention of affective status disorders in cancer patients, its dynamic control and timely correction.
Aim. Comparative analysis of the effect of hydrochloric, malic and succinic salts of 2-ethyl-6-methyl-3-oxypyridine (methylethylpyridinol, ethylmethylhydroxypyridine malate, ethylmethylhydroxypyridine succinate) on the dynamics of self-assessment of depression manifestations in women recieving radiation therapy after surgical treatment of uterine cancer.
Material and methods. A short-term, prospective, simple blind, placebo-controlled, randomized study of the effect of methylethylpyridinol, ethylmethylhydroxypyridine malate and ethylmethylhydroxypyridine succinate on the severity of depression symptoms in patients receiving radiation therapy after extended extirpation of the uterus with appendages was performed. The study was completed by 96 patients. Course two-week administration of drugs in almost equimolar single doses (0.830.88 mmol) was started simultaneously with radiation therapy. The treatment effectiveness was assessed using the Beck Depression Inventory 2 and 4 weeks after the start of the study. Statistical comparison of related samples was carried out using the Friedman test and post hoc analysis using the paired Wilcoxon test with the Bonferroni correction. Independent samples were compared using the KruskalWallis test with a post hoc analysis using the DanBonferroni test.
Results. Radiation therapy was found to cause a clinically significant increase in the severity of depressive symptoms in 14 and 28 days after the start of the study (p 0.010). Two-week administration of methylethylpyridinol, ethylmethylhydroxypyridine malate, and ethylmethylhydroxypyridine succinate reduced the severity of depressive symptoms to the normal level (p 0.001), mainly due to a decrease in the severity of symptoms of the cognitive-affective cluster (p 0.001). The studied drugs with equal severity prevented the escalation of depression symptoms according to the Beck Depression Inventory (p ˃0.05).
Conclusion. Hydrochloric, malic and succinic salts of 2-ethyl-6-methyl-3-oxypyridine are equally effective in preventing the development of depression during postoperative radiation treatment of patients with ute-rine cancer.
Features of hemodynamic and structural parameters of the heart in young people with varying stages of cardiometabolic risk
Authors: Parve Swapnil D. , Sineglazova Albina V.
Published: October 2022

Background. Cardiometabolic diseases are one of the leading causes of disability and mortality worldwide, which justifies the relevance of studying their early manifestations.
Aim. To analyze the hemodynamic and structural echocardiographic parameters of the heart in relation to cardiometabolic risk factors and its staging according to the Cardiometabolic Disease Staging (CMDS) scale in young patients.
Material and methods. 109 patients were examined: 57 males (52.3%) and 52 females (47.7%) aged with a median of 36.1 [32.639.2] years without cardiometabolic diseases. The design of the study was a cross-sectional case-control study. The parameters of cardiometabolic risk were assessed with its calculation and assessment taking into account the stage according to the CMDS scale. Echocardiography was performed in M- and B-modes. The data were processed using the SPSS Statistics 23 program. The MannWhitney U test, the KruskalWallis test, and the Pearson and Fisher 2 tests were used. Correlation analysis according to Spearman was carried out.
Results. The first stage of cardiometabolic risk was established in 17 examined patients (15.6%), the rest had stage 2 (n=57; 52.3%) or stage 3 (n=35; 32.1%) of cardiometabolic risk. Deviations from the normal values of hemodynamic echocardiographic parameters were not revealed. The frequency of increase in the index of relative thickness, the thickness of the posterior wall of the left ventricle, the interventricular septum thickness, the myocardium mass of the left ventricle did not differ (p=0.1980.983). A direct correlation between the left atrial, end-systolic and diastolic volumes, left ventricle wall thickness, and an inverse relationship between the left ventricular ejection fraction and cardiometabolic risk factors was established. At the 3rd stage of cardiometabolic risk, higher values of the left atrial volume (47 [4649] ml; p=0.005), end-systolic (30.42 [29.2332.04] ml; p=0.001) and diastolic (79 [7881] ml; p=0.003) volumes of the left ventricle and lower left ventricular ejection fraction (61 [60.3562.65] ml; p=0.004) than on the 1st and 2nd stages were diagnosed.
Conclusion. An increase in the cardiometabolic risk is associated with an increase in preload and afterload on the left heart.
The effect of the surgical treatment in the complex management on life expectancy of thymic Hodgkin's lymphoma
Authors: Fokeev Sergey D. , Lazarev Alexander F. , Kapitulin Stanislav Yu. , Kazantseva Elena S. , Kapitulina Elina K.
Published: October 2022

The result of treatment of primary Hodgkin's lymphoma lesion of the thymus gland of a 26-year-old patient is presented. At the preoperative stage of examination, tumor maligna cells were obtained during puncture of mediastinal formation. The diagnosis is malignant tumor of the mediastinum. Considering this, a surgical treatment was performed-radical removal of the mediastinal tumor. After the study of the postoperative drug, a clinical diagnosis was made: lymphogranulomatosis, a massive (bulky) tumor lesion of the mediastinum, stage IIХ, after surgical treatment. First course of ABVD chemotherapy was performed 28 days after the operation. When performing the second course of chemotherapy according to the same scheme, the patient developed complications in the form of moderate leukocytopenia (leukocytes, 0.9109/l) and stomatitis. Special treatment was discontinued, and the patient was observed by an oncologist in the polyclinic of an oncological dispensary.
At the next examination, which was performed 11 months later, a relapse of the disease was identified. Considering the preservation of persistent leukopenia (leukocytes, 3.0109/l), it was decided to conduct six courses of ABVD polychemotherapy with prednisone, against the background of G-CSF. At this stage of oncology, the main method of treating Hodgkin's lymphoma is chemo-hormone therapy in combination with radiation therapy. The performed non-standard complex treatment is radical surgical removal of a mediastinal tumor followed by polychemotherapy. It allowed 4 years after the completion of treatment to know motherhood, which did not affect the patient's health. As indicated by the long relapse, free period of the disease is 16 years, and life expectancy is 18 years.
Исторические аспекты нормативно-правового регулирования работы аптек как структурных подразделений медицинских организаций
Authors: Perelygin Vladimir V. , Pokhvalenko Elisaveta V. , Zolotareva Natalia G. , Zharikov Mikhail V.
Published: October 2022

Along with the development and improvement of the structure of medical organizations, much attention is paid to the drug provision of the therapeutic and diagnostic process in them, which contributes to improving the quality of medical care.
Our theoretical research is based on a practical analysis of empirical data of regulatory and legal acts and documents regulating the issues of drug provision of medical organizations in Russia and abroad. Structural and functional analysis by the authors was used in the study of abstract and full-text databases published in digital online resources with materials of drug provision for medical and diagnostic work; infographics and scientific articles.
The study has revealed that a number of requirements for pharmaceutical activities of pharmacy organizations and modern requirements for drug provision for the implementation of therapeutic and diagnostic activities do not correspond to the dynamic development of drug provision for patients of medical organizations.
We came to the conclusion that, in modern conditions of the development of medical care to the population, in general, there are enough regulatory legal acts and documents for the organization of the work of pharmacy organizations as structural divisions of medical organizations. But, if we take into account the diversity of medical organizations, their profile, the possibility of changing the structure of medical departments, directions of medical care, then this may require changing the nomenclature of ready-made and manufactured medicines in specific conditions.
As the results of the study have shown, joint efforts of all stakeholders in pharmacy and healthcare, as well as regulators of pharmaceutical and medical activities are needed to develop standard organizational and methodological recommendations for medical organizations carrying out medical and diagnostic activities based on the best traditions of Good Pharmacy Practice (GPP) and the International Pharmaceutical Federation (FIP). At the heart of this work, in our opinion, it is necessary to organize experimental studies using functional mathematical models of pharmacy activity in a number of therapeutic and preventive medical organizations to digitalize the organization of drug provision in them with expert evaluation of the results by specialists of all interested parties.
Immediate results of micropulse cyclophotocoagulation in glaucoma in children
Authors: Panova Anna Yu. , Katargina Lyudmila A. , Denisova Ekaterina V. , Sorokin Aleхаndеr  A.
Published: October 2022

AIM: This study aimed to investigate the efficacy and safety of micropulse cyclophotocoagulation (MP-CPC) in the treatment of various types of glaucoma in children.
MATERIAL AND METHODS: The study included 14 children (15 eyes) with uncompensated glaucoma of various etiologies, who underwent MP-CPC using the Cyclo G6 laser system (IRIDEX, USA). The intervention was considered absolutely effective when IOP reached 8 to 25 mm Hg without medications and without signs of progression of glaucoma, relatively effective, when the same criteria are achieved with hypotensive medications.
RESULTS: The average age of children at the time of intervention was 8.51.5 yr (from 7 months to 17 yr). The average level of IOP before surgery was 28.51.1 mm Hg, 3 days after MP-CPC (18.871.04 mm Hg), while the absolute efficiency was 14.3%, relative 100%. By the end of the observation period (16 months; on average, 2.50.4 months), the average IOP was 24.41.31 mm Hg (average decrease, 14.3%), with absolute efficiency of 0% and relative of 66.7%. The average number of hypotensive medications received in instillations did not change significantly before and after MP-CPC and amounted to 3.450.22 and 2.910.39, respectively (p=0.167). Complications after MP-CPC were detected in six eyes (40%); in all cases, the appearance or increase of the inflammatory reaction in the anterior chamber was observed. In addition, in two eyes (13.3%). In addition, a slight mydriasis (45 mm) developed.
CONCLUSION: MP-CPC is a safe and effective treatment for glaucoma in children with various etiologies. Further research is needed to evaluate the effectiveness of intervention in the long term and the safety of repeated procedures to achieve normal IOP and to develop individual schemes of MP-CPC.
A clinical case of choroidal detachment as choroidal effusion in a child with Sturge-Weber-Crabbe syndrome
Authors: Shilov Alexander I. , Pravosudova Marina M. , Shefer Kristina K.
Published: October 2022

Choroidal effusion syndrome is a rare idiopathic condition that occurs predominantly in middle-aged man with hyperopia and is characterized by ciliochoroidal detachment (CD), followed by exudative retinal detachment. To present a clinical case of postoperative choroidal detachment in a child with SturgeWeberCrabbe syndrome after microinvasive non-penetrating glaucoma surgery.
RESULTS: This article presents the clinical case of postoperative choroidal detachment in a child with SturgeWeberCrabbe syndrome after microinvasive non-penetrating glaucoma surgery. Against the background of the existing anomalies in the development of an optic disc after antiglaucomatous intervention for decompensated glaucoma, after the normalization of IOP, the patient developed choroid detachment with exudative retinal detachment the next day of operation. After conservative therapy involving bed rest and double instillation of mydriatics for 1 month, the situation was completely resolved and his vision was restored to 1.0.
DISCUSSION: The atypicality of our clinical case of CD lies in the overly pronounced exudative component. In addition to the classic CD vesicles, we observed high exudative retinal detachment as well as high retinoschisis, which is extremely atypical for classical CD. Considering the characteristics of congenital syndrome, it is necessary to accurately differentiate atypical CCA from the rare choroidal effusion syndrome, which also includes CCA with retinal detachment, but does not present with retinoschisis. Against the background of conservative therapy with bed rest and two instillations of mydriatics for 1 month, the situation was completely resolved, and the patients vision was restored to 1.0. In the treatment of such patients, it is always necessary to consider their individual anatomical features as well as to understand the detailed pathogenesis of the complications that arise before rushing to repeat surgery.
The content of matrix metalloproteinase-9 in aqueous humor of the eyes in children with endogenous uveitis
Authors: Katargina Lyudmila A. , Chesnokova Natalya  B. , Denisova Ekaterina V. , Khrabrova Maria  A. , Beznos Olga V.
Published: October 2022

AIM: This study aimed to determine the content of matrix metalloproteinase-9 (MMP-9) in the aqueous humor (AH) of the eyes in children with uveitis and its role during the disease.
MATERIAL AND METHODS: Twenty children (20 eyes with uveitis) aged from 3 to 16 yr (11.253.43 yr on average) and three children with congenital cataract from the control group were examined. The concentration of MMP-9 was determined by enzyme-linked immunosorbent assay (ELISA) using the ELISA kit for MMP-9 (Cloud-Clone Corp, USA). The optical density of the samples was measured using a multifunctional photometer for Synergy microplates (BioTek, USA).
RESULTS: Children with uveitis had a higher content of MMP-9 in the AH than children in the control group (p=0.006). An increase in the content of MMP-9 in the AH of the eyes was correlated with an increase in the degree of proliferative changes in the eye.
CONCLUSION: The concentration of MMP-9 in the AH of the eyes correlates with the severity of proliferation, and its measurement can be used to assess the severity of the inflammatory process in the eye.
The role of clinical metabolomics in the diagnosis of bladder cancer
Authors: Zamyatnin Sergey A. , Malushko Anton V. , Gonchar Irina S.
Published: October 2022

BACKGROUND: Bladder cancer is a widespread disease characterized by high cancer-specific mortality and high cost of treatment. The search for available and reliable biological markers for the early diagnosis of urothelial carcinomas is an urgent task of oncourology. One of the promising ways to improve the efficiency of bladder cancer diagnostics is the use of the possibility of the clinical metabolomics.
AIM: Was to study the possibility of assessing the content of various amino acids and their metabolites in blood serum for the diagnosis of bladder cancer.
MATERIALS AND METHODS: Serum concentrations of 28 amino acids and their metabolites were studied in 18 patients with urothelial cancer and 20 representatives of the control group without an oncological history. History taking, routine oncological screening, and blood sampling for laboratory tests were performed.
RESULTS: Four metabolomes (glycine, phenylalanine, asparagine, and threonine) were identified, the blood serum concentration of which significantly changes in patients with urothelial cancer. These metabolomes can be considered as potential biomarkers of urothelial cancer.
CONCLUSIONS: The study of the serum content of these four amino acids seems to be the most promising for the isolation of a potential biomarker of urothelial cancer.
Post-COVID syndrome in urological practice
Authors: Kuzmenko Andrey V. , Petrova Daria A. , Gyaurgiev Timur А.
Published: October 2022

This review article examines the impact of the SARS-CoV-2 coronavirus on the urinary system, as well as on mens health. Data on aspects of pathogenesis and features of the course of a new coronavirus infection are presented. Possible risk factors for contracting a new coronavirus infection associated with an abundance of angiotensin-converting enzyme-2 (ACE2) receptors in the kidneys and urinary tract, to which SARS-CoV-2 has an affinity, are considered. The article provides an extensive range of studies that provide convincing evidence for the presence of changes in the spermogram of patients who have undergone COVID-19. Works demonstrating gender differences in the incidence of COVID-19 and concomitant diseases are presented. The literature review considers both direct and indirect factors (oxidative stress, cytokine storm, decreased libido), through which coronavirus infection negatively affects male sexual health.
Muhammadiyah dan Moderatisme Islam Indonesia
Authors: Lorinda Rosa
Published: October 2022

Muhammadiyah adalah salah satu organisasi Islam terbesar di Indonesia. Dengan maraknya perkembangan pemikiran dan kelompok ektremis dan radikal yang menyebabkan intolerasansi antar umat beragama berkembang dan membuat situasi memanas. Muhammadiyah sebagai organisasi dakwah hadir dengan Islam moderat dan berkemajuannya. Islam moderat yang diusung oleh Muhammadiyah adalah Islam yang berada di tengah artinya tidak ekstrim ke kanan (Islam radikal/konservativ) dan juga tidak ke kiri yaitu Islam liberal. Tokoh-tokoh muhamadiyah banyak menyerukan Islam moderat seperti Buya Syafii Maarif, KH. Din Syamsuddin, dan KH. Haedar Nashir. Majlis tarjih sebagai lembaga yang mengeluarkan fatwa di Muhammadiyah adalah wajah dari organisasi muhammadiyah. Fatwa-fatwa yang dikeluarkan oleh Majlis Tarjih adalah fatwa yang dapat menentukan apakah masyarakat akan memandang Muhammadiyah sebagai Islam moderat dan berkemajuan seperti yang diserukan atau tidak.
PEMBENTUKAN REGULASI DESA TENTANG PRINSIP, PROSEDUR, DAN KODE ETIK PENYELESAIAN SENGKETA PERTANAHAN
Authors: Sunarno Sunarno , Ahmad Yulianto
Published: October 2022

Karakter tanah dalam kehidupan manusia akan semakin selalu menjadi epicentrum komplek sengketa kemanusiaan seiring dengan kompleknya kepentingan kemanusiaan diatasnya. Sementara itu, kesadaran masyarakat dan ketrampilannya tidak tumbuh seiring dengan itu. Oleh karena itu pengabdian PPDM ini bermitra dengan segenap Perangkat Pemerintahan Desa Wates untuk mencapai tujuan pengabdian berupa tuntutan peningkatan kapasitas untuk menyelesaian sengketa berupa: 1. memperkuat pemahaman makna tanah dan faktor fundamental adanya sengketa; 2. memberian pelatihan untuk mencapai skill penyelesaian sengketa melalui ADR; dan 3. Pengembangan sistem Kerja kelembagaan penyelesaian sengketa tanah. Dan 4. Jabaran dari no 3 itu yaitu dengan memperkuat sistem kelembagaan dengan regulasi kode etik penyelesaian sengketa bagi tokok masyarakat tersebut. Metode yang dipakai adalah pemberian konsultasi, workshop dan simulasi. Hasilnya bahwa pembuatan regulasi desa berjalan dengan hasil pemahalan yang baik dari tokoh dan Perangkat desa tentang arti pening dan format regulasi, worshop menghasilkan rancangan regulasi kode etik yang sistemais yang disesuaikan dengan tuntutan masyarakat. Simulasi menghasilkan skil peran tokoh yang standar sesuai regulasi yang ada. Implikasi dari regulasi ini maka terdapat konsesus bersama antar tokoh dan warga tentang kedudukan regulasi sebagai kontrak sosial bersama. Simpulan dari pengabdian ini adalah diterapkan iptek berupa pembuatan regulasi kode etik penyelesaian sengketa sebagai bagian dari tata kelola tupoksi kelembagaan di desa mitra oleh Perangkat desa dan tokoh masyarakat berupa kemampun menyelesaian sengketa yang timbul dengan upaya damai dan harmonis ditingkat masyarakat setempat. Penguatan kelembagaan mediasi di desa wates beserta norma dan standar serta kode etik penyelesaian sengketa menjadi tumpuan untuk terwujudnya sistem pencegahan dan penanggulangan  penyelesaian sengketa
PEMANFATAAN MEDIA ONLINE UNTUK KOMUNIKASI DAN KONSULTASI PROGRAM PENDIDIKAN KESEHATAN REPRODUKSI REMAJA
Authors: Ishak Aswad , Sumaryani Sri
Published: October 2022

Nasyiatul Aisyiyah Daerah Bantul hadir untuk membantu para remaja mencapai hidup sehat dengan mengadakan program Pelayanan Remaja Sehat Milik Nasyiyatul Aisyiyah (PASHMINA). Pada situasi normal, program PASHMINA dijalankan dengan mengadakan pertemuan tatap muka secara langsung. Situasi berubah sejak SARCOV-19 melanda Indonesia sejak Februari 2020 hingga kini. Keadaan pandemi covid masih belum dapat diprediksikan waktu akan berakhirnya. Banyak persoalan baru yang dihadapi remaja pada masa pandemi. Sehingga diperlukan konseling bagi persoalan remaja terkait  kesehatan reproduksi (kespro)  yang  dihadapi  selama masa pandemi. Media komunikasi tatap muka yang selama ini berjalan tidak lagi terlaksana. Hingga saat ini Pimpinan Daerah Nasyiyatul Aisyiyah (PDNA) Bantul belum memiliki media online yang dapat digunakan sebagai sarana komunikasi konseling. Program ini bertujuan untuk membuat media online yang diperlukan dan memberikan pelatihan teknik komunikasi. konseling virtual, dan penggunaan media edukasi online untuk meningkatkan kualitas pelayanan PASHMINA. Dengan meningkatkan kemampuan petugas terkait skills komunikasi khususnya melalui media online dan konseling pada pos kesehatan reproduksi dan gizi, serta tersedianya media edukasi online dapat membantu petugas untuk memberikan konseling yang efektif dalam situasi pandemi covid. Hasil akhir menunjukkan media komunikasi yang dipilih untuk layanan konsultasi online adalah instragram karena banyak diakses oleh remaja. Keterampilan komunikasi menggunakan media online bagi petugas perlu ditingkatkan untuk membantu remaja menyelesaian persolan kesehatan reproduksi yang dialami.
PEMBERDAYAAN IBU RUMAH TANGGA PADA PENANGANAN NYERI DI RUMAH BERBASIS SOSIAL MEDIA
Authors: Arianti Arianti , Hidayati Ari Budiarti Sri
Published: October 2022

Nyeri merupakan akibat langsung maupun tidak langsung pada beberapa penyakit. Namun pada kenyataannya pada pasien dengan nyeri sedang dan berat banyak yang tidak mendapatkan akses langsung pada obat anti nyeri. Ibu rumah tangga sebagai orang yang paling bertanggungjawab dan berperan saat ada anggota keluarga yang sakit, terkadang bingung dengan kondisi anggota keluarganya yang mengalami rasa nyeri. Beberapa terapi mengurangi nyeri terbukti efektif dan bisa dilakukan di rumah sambil menunggu obat nyeri atau tindakan dari medis. Tujuan: Pengabdian masyarakat ini bertujuan untuk mengajarkan ibu rumah tangga dalam manajemen nyeri di rumah. Metode: Metode yang digunakan adalah pelatihan manajemen nyeri rumah tangga berbasis sosial media (Whatsapp Group) dan edukasi online (meeting zoom). IPTEK yang digunakan adalah pemanfaatan media social dan video edukasi untuk mengajarkan ibu rumah tangga cara mengenal nyeri dan penanganan nyeri di rumah. Hasil: 10 orang ibu rumah tangga mengikuti pelatihan ini, terdapat peningkatan pengetahuan berdasarkan rata-rata nilai pre tes 56.4% menjadi 75% pada post tes. Mitra juga menghasilkan tiga video mengenal dan menangani nyeri di rumah sebagai evaluasi keterampilan.. Implikasi: Peningkatan pengetahuan dan keterampilan yang diperoleh selama pelatihan nyeri diharapkan akan ditindaklanjuti dan bermanfaat untuk keluarga maupun masyarakat di Baturetno. Kesimpulan: Ibu rumah tangga ada manajer kenyamanan bagi seluruh anggota keluarganya, dan pelatihan nyeri diakui sangat bermanfaat bagi mereka
RANCANG APLIKASI E-KPI PLUS PENILAIAN KINERJA KARYAWAN RUMAH SAKIT
Authors: Aini Qurratul , Hidayah Nur
Published: October 2022

Sumber daya manusia yang berkualitas sangat dibutuhkan dalam bidang pelayanan pada masyarakat, khususnya bidang pelayanan kesehatan. Pada bidang  kesehatan banyak pihak yang akan terlibat baik tenaga medis maupun tenaga non medis. Kualitas SDM harus diperhatikan untuk memenuhi standar pelayanan maksimal. Pengawasan terhadap kualitas SDM sering kali tidak diperhatikan karena tertutup oleh fokus hanya pada kualitas fasilitas dan mutu secara umum pada rumah sakit. Penilaian kinerja karyawan menjadi salah satu alternative untuk mengukur kualitas kerja sekaligus mengawasi kinerja karyawan selama periode tertentu. Pelaksanan penilaian kinerja masih dilakukan secara manual sehingga tidak jarang ditemukan kendala pada pengumpulan dan pengelolaan data. Penilaian kinerja selain untuk mengukur kualitas pelayanan karyawan digunakankan untuk peningkatan produktivitas lembaga yang berkaitan dengan kebijaksanaan terhadap pegawai. Tujuan dirancangnya aplikasi e-KPI plus kinerja karyawan untuk memberikan inovasi baru dalam penilaian dengan memanfaatkan teknologi sehingga waktu untuk pengelolaan data lebih efisien, pengumpulan data yang efektif. Menggunakan mixed methode yang dilaksanakan pada Rumah Sakit Islam Aisyiyah Klaten. Sistem Penilaian memperhatikan visi, misi dan tujuan dari lembaga yang melaksakan sehingga tidak menyimpang dengan standar pelayanan rumah sakit. Desain penilaian dikembangkan dengan menginput data berupa checklist, essay maupun pencatatan kegiatan yang dilaksanakan. Karyawan dapat melaksanakan penelitian kinerja diwaktu luang tanpa mengurangi jam produktif.
PEMANFAATAN QR CODE SEBAGAI MEDIA PEMBUATAN INSTRUMEN EVALUASI BAHASA JEPANG
Authors: Rahayu Poppy , Rachman Fadhil Ghufran Anwari , Arafat Muhamad Zulfikar , Rifqiaulian Tegar
Published: October 2022

Kapasitas kemitraan perlu ditingkatkan melalui keterlibatan setiap individu maupun kelompok yang akan menjadi penggerak perubahan pada pembangunan berkelanjutan sebagai sarana dalam mencapai seluruh tujuan dan target SDGs. Dalam kaitannya dengan bidang pembelajaran, instrumen evaluasi memiliki peranan yang sangat penting. Banyak media yang dapat digunakan untuk membuat instrumen evaluasi pembelajaran bahasa Jepang, salah satunya adalah kode QR. Kondisi ini mendorong penulis untuk menjadikan QR code sebagai media evaluasi bahasa Jepang, dan mensosialisasikannya dalam kegiatan pengabdian masyarakat bagi guru-guru SMA. Metode pengabdian yang digunakan berupa pelatihan kepada guru-guru bahasa asing di SMA Negeri 15 Bekasi, dalam bentuk training of trainers. Metode pelaksanaan pelatihan ini dimulai dengan pembuatan media panduan. Setelah itu, dilaksanakan workshop secara luring dengan memperhatikan protokol kesehatan, serta disiapkan sebagai training of trainers. Melalui strategi training of trainers ini, diharapkan dapat tersosialisasi dengan baik dan banyak digunakan dalam pembelajaran. Dari kegiatan pengabdian ini dapat disimpulkan bahwa kegiatan ini mendapat respon yang positif. Para guru diharapkan dapat menerapkannya dalam kegiatan belajar mengajar di kelas secara efektif serta menanamkan jiwa kreativitas dalam pembuatan media untuk evaluasi. Jika kode QR dimanfaatkan sebagai media instrumen evaluasi bahasa Jepang, maka dapat memperkaya media instrumen dan meningkatkan kemampuan guru di bidang teknologi.
PENINGKATAN KUALITAS KESEHATAN MELAUI EDUKASI PENGGUNAAN OBAT DAN HERBAL BAGI BINAAN RUMAH ZAKAT
Authors: Winanta Aji , Widada Hari , Febriansah Rifki , Rizqi Muhammad Arif
Published: October 2022

Informasi pengunaan obat-obat alternatif yang dapat berkhasiat untuk mengobati covid-19 yang tidak pasti membuat kepanikan di masyarakat. Pemanfaatan obat tradisional di era pandemi Covid-19 sangat bermanfaat sebagai pencegahan yaitu untuk meningkatkan daya tahan tubuh, atau sebagai pelengkap (komplemen) obat konvesional yang diberikan pada pasien Covid-19 sehingga daya tahan tubuh seseorang menjadi semakin bagus. Rumah zakat yang merupakan lembaga filantropi yang mengelola zakat, infak sedekah, serta dana sosial lainnya melalui program Senyum Sehat (kesehatan) berupaya dapat bermanfaat di bidang kesehatan. Program pengabdian masyarakat yang akan dilakukan bertujuan untuk meningkatkan kualitas kesehatan melalui edukasi penggunaan obat dan herbal yang benar bagi binaan rumah RUMAH ZAKAT Sleman, DIY. Metode pelaksanaan program didahului dengan observasi lingkungan, kemudian pelaksanaan program menggunakan metode ceramah/diskusi. Pelaksanaan ceramah/diskusi tentang penggunaan obat dengan metode CBIA (Cara Belajar Insan Aktif) yang dilaksanakan secara luring dan daring sebanyak 3 kali pertemuan. Selain ceramah juga dilaksanakan praktek budidaya tanaman herbal dan pemanfaatannya. Diakhir pelaksanaan dilakukan evaluasi terkait pelaksanaan program. Khalayak sasaran untuk kegiatan ini yaitu remaja dan orang tua binaan rumah zakat Sleman, Yogyakarta. Luaran yang akan dicapai diharapkan dapat memberikan pengetahuan dan bekal bagi binaan rumah zakat mengenai penggunaan obat yang benar serta pemanfaat budidaya tanaman herbal. Hasil program pengabdian menunjukan peningkatan pemahaman masyarakat tentang penggunaan obat yang ditunjukkan dengan peningkatan nilai pada tahap post-test. Pemberian edukasi dapat meberikan efek positif terkait kualitas kesehatan masyarakat. Hasil kegiatan ini juga akan dimuat dalam suatu artikel ilmiah yang akan dipublikasikan dalam jurnal ber ISSN.