bluuebunny/crossref_metadata_2025 huggingface dataset:
NKp46 enhances type 1 innate lymphoid cell proliferation and function and anti-acute myeloid leukemia activity
Authors: Ma Rui , Li Zhenlong , Tang Hejun , Wu Xiaojin , Tian Lei , Shah Zahir , Liu Ningyuan , Barr Tasha , Zhang Jianying , Wang Sean , Swaminathan Srividya , Marcucci Guido , Peng Yong , Caligiuri Michael A. , Yu Jianhua
Published: January 2025

NKp46 is a critical regulator of natural killer (NK) cell immunity, but its function in non-NK innate immune cells remains unclear. Here, we show that NKp46 is indispensable for expressing IL-2 receptor-α (IL-2Rα) by non-NK liver-resident type-1 innate lymphoid cells (ILC1s). Deletion of NKp46 reduces IL-2Rα on ILC1s by downregulating NF-κB signaling, thus impairing ILC1 proliferation and cytotoxicity in vitro and in vivo. The binding of anti-NKp46 antibody to NKp46 triggers the activation of NF-κB, the expression of IL-2Rα, interferon-γ (IFN-γ), tumor necrosis factor (TNF), proliferation, and cytotoxicity. Functionally, NKp46 expressed on mouse ILC1s interacts with tumor cells through cell–cell contact, increasing ILC1 production of IFN-γ and TNF, and enhancing cytotoxicity. In a mouse model of acute myeloid leukemia, deletion of NKp46 impairs the ability of ILC1s to control tumor growth and reduces survival. This can be reversed by injecting NKp46+ ILC1s into NKp46 knock-out mice. Human NKp46+ ILC1s exhibit stronger cytokine production and cytotoxicity than their NKp46− counterparts, suggesting that NKp46 plays a similar role in humans. These findings identify an NKp46–NF-κB–IL-2Rα axis and suggest that activating NKp46 with an anti-NKp46 antibody may provide a potential strategy for anti-tumor innate immunity.
Symbolic regression for strength prediction of eccentrically loaded concrete-filled steel tubular columns
Authors: Megahed Khaled
Published: January 2025

Concrete-filled steel tube (CFST) columns are widely employed in high-rise buildings, long-span bridges, and seismic-resistant structures due to their superior load-bearing capacity, structural efficiency, and resilience under extreme loading conditions. This study uses symbolic regression with structural design code provisions to predict the eccentric strength of concrete filled-steel tubular columns with circular shape (CCFST) and rectangular shape (RCFST). Previous studies have used two distinct approaches for estimating eccentric strength: explainable models based on theoretical derivations and black-box models derived from machine learning (ML) methods. This study proposes a hybrid model derived from the design code standards, with performance enhanced by the symbolic regression technique. This model is based on a comprehensive experimental database of 464 tests for CCFST columns and 313 tests for RCFST columns under eccentric loading from various research papers. The developed code-based symbolic regression (C-SR) displays both robust and interpretable, demonstrating high prediction accuracy with mean values of the prediction-to-actual ratios of 1.006 and 0.997 and coefficient of variation (CoV) values of 0.117 and 0.098 for CCFSTs and RCFSTs, respectively, while providing explainable mathematical expressions that align with the mechanical principles of code provisions. The developed C-SR model is benchmarked against EC4 and AISC360 standards and evaluated against the various ML techniques, demonstrating acceptable performance. The results highlight the C-SR model’s effectiveness in providing reliable predictions and valuable insights for practical engineering applications.
Segmental analysis of human hair reveals intra-annual variation in 25(OH)D3 concentrations in modern and archaeological individuals
Authors: Britton Kate , Czére Orsolya , Gutierrez Eléa , Reynard Linda M. , Laird Eamon , Duncan Gary , de Roos Baukje
Published: January 2025

Vitamin D is essential for healthy skeletal growth and is increasingly recognised for its role in chronic disease development, inflammation and immunity. 25-hydroxyvitamin D3 (25(OH)D3) concentrations are an indicator of vitamin D status and are normally analysed in plasma or serum samples in clinical settings, while archaeological studies rely on the identification of skeletal markers of vitamin D deficiency, such as rickets. Here, we determined 25(OH)D3 concentrations in hair specimens (‘locks’) that had been sampled close to the root, aligned by cut end, and sliced into sequential segments from participants (n = 16), from Aberdeen, Scotland, using a modified protocol designed to minimise sample size. Concentrations were above detectable levels in 14 of 16 individuals, generating a (~ monthly) time-series of 25(OH)D3 concentrations, with fluctuating intra-hair trends consistent with the bioaccumulation of 25(OH)D3. In three participants, fluctuations in intra-hair 25(OH)D3 appear linked to recent significant weight loss, potentially due to the release of stored 25(OH)D3 from adipose tissue and subsequent uptake in hair. For the remaining participants, no statistically-significant correlations were determined between mean hair 25(OH)D3 levels and self-reported data, including age, sex, BMI, vitamin D supplementation, frequency of oily fish consumption, and hours spent outside. For a subset of our cohort (n = 4) isotope analysis highlighted potential relationships between elevated δ
18O values (which can indicate season of hair growth) and 25(OH)D3 concentrations in some individuals, which may reflect seasonally-increased UVB exposure. We also present data from an archaeological individual from the same city, with the addition of further isotope analysis (carbon, nitrogen, sulphur) to characterise diet. Results suggest possible positive correspondence of 25(OH)D3 levels with season in this archaeological individual, and possibly with marine protein consumption, highlighting the potential use of this approach in characterising the relationship between past vitamin D levels and diet. While results are promising, we recognise the limits of this study in terms of sample size and use of self-reported data, and further work is needed to better understand the relationship between serum and hair 25(OH)D3 before this approach can further be developed as either a non-invasive medical test or an archaeo-investigative technique.
Preparation and characterization of SPE column with smart green molecularly imprinted polymers materials for selective determination of S-metolachlor herbicide
Authors: Rapacz Dominika , Smolińska-Kempisty Katarzyna , Wolska Joanna
Published: January 2025

The presence of traces of herbicides in ground and surface waters can have adverse impacts on humans and the environment. Therefore, developing a highly selective and reusable adsorbent for monitoring water quality has become important. This article describes smart green molecularly imprinted polymers (MIPs) as selective sorbents of S-metolachlor herbicide for solid phase extraction (SPE). Combining the MIP-SPE column with HPLC chromatography provided a quick and accurate method for determining the real concentration of S-metolachlor in water samples. The sorption capacity of the MIP-SPE column was almost twice that of the non-imprinted polymer column for SPE extraction. The bed can be regenerated up to three times before it loses its original sorption properties. A method has been developed whereby 6 ml of water can achieve an average recovery rate of 98% for sorbent. During the selectivity study from multicomponent solution, the calculate imprinting factor for MIPs was calculated to be 10, while MIPs sorb S-metolachlor 10 times better than atrazine, 12 times better than fenoxaprop-P-ethyl and 33 times better than glyphosate. The pseudo-second-order kinetic model was in good agreement with the experimental values obtained.
Molecular imaging of viral pathogenesis and opportunities for the future
Authors: Kelly Brianna , Boudreau Jeanette E. , Beyea Steven , Brewer Kimberly
Published: January 2025

Molecular imaging is used in clinical and research settings. Since tools to study viral pathogenesis longitudinally and systemically are limited, molecular imaging is an attractive and largely unexplored tool. This review discusses molecular imaging probes and techniques for studying viruses, particularly those currently used in oncology that are applicable to virology. Expanding the repertoire of probes to better detect viral disease may make imaging even more valuable in (pre-)clinical settings.
Multi-site enzymatic repairing amplification (MSERA) enables ultrasensitive detection of terminal deoxynucleotidyl transferase activity
Authors: Zhou Dianming , Meng Tao , Zhang Dalong , Zhang Jianyu , Fang Zhongze , Gong Xiaoqun , Qian Zhiyong , Zhang Mingyue
Published: January 2025

A novel multi-site enzymatic repairing amplification method was developed for Tdt activity analysis with simplified design and outstanding sensitivity.
Constructing a built-in electric field by grafting strong electronegative small molecules for photocatalytic H2 production
Authors: Li Mingtao , Yu Wenying , Tian Na , Zhang Yihe , Huang Hongwei
Published: January 2025

FCN with an asymmetric structure possesses spatially separated redox sites, which is attributed to the built-in electric field by grafting small molecules onto g-C3N4, resulting in excellent H2 production performance.
The need for robust model systems in the study of hybrid interfaces for photocatalysis and photoelectrocatalysis
Authors: Mohandas Mekha P. , Bruce Jared P.
Published: January 2025

Surface science studies on robust model systems, including small molecule adsorption, hold great promise in revealing critical structure and chemistry-function relationships for optimizing light-driven energy conversion technologies.
A physicochemical investigation of the complex formation by β-cyclodextrin with Triton X-100 and Triton X-114 and their aggregation behaviour in aqueous solution: an experimental approach
Authors: Banik Rajesh , Sardar Raju , Mondal Bipin Bihari , Ghosh Soumen
Published: January 2025

The complexation behavior and binding affinity of Triton X-100 (TX-100) and Triton X-114 (TX-114) with β-cyclodextrin (β-CD) were extensively studied in an aqueous medium using a comprehensive suite of experimental techniques.
Stability and superconductivity of hexagonal prism-structured polyhydrides X2MgH18 (X = Li, Na, K, Rb, Cs) under moderate pressure
Authors: Zha Liliang , Jiang Jiajun , Xue Yamin , Cheng Zebang , Yao Shunwei , Hu Wenjing , Peng Lin , Shi Tingting , Chen Jing , Liu Xiaolin , Lin Jia
Published: January 2025

We searched for compounds X2MgH18 (X = Li, Na, K, Rb, Cs) and identified Li2MgH18 as dynamically stable and superconducting at 20 GPa (110 K) and 235 GPa (122 K). The distortion of its hexagonal prism structure enhances the critical temperature (Tc).
Biophysics-guided uncertainty-aware deep learning uncovers high-affinity plastic-binding peptides
Authors: Alshehri Abdulelah S. , Bergman Michael T. , You Fengqi , Hall Carol K.
Published: January 2025

Evidential deep learning helps explore peptide sequences to identify those with high predicted affinity for plastic.
Low-cost electrochemical gas sensing of vertical differences in wintertime air composition (CO, NO, NO2, O3) in Fairbanks, Alaska
Authors: Roberts Tjarda , Cesler-Maloney Meeta , Simpson William
Published: January 2025

Wintertime Fairbanks, Alaska, experiences episodes of severely poor air quality, when local emissions (e.g. from home-heating, vehicular) are enhanced by cold conditions and are trapped by temperature inversions. Monitoring of...
A supported Fe/Ru catalyzed three-component relay reaction through a hydrogen borrowing strategy: conversion of crude α-hydroxy acids into valuable N-heterocycles
Authors: Liu Shanshan , Wan Jia , Zhang Yaoyao , Luo Wen-Yu , Dong Weiwei , Wang Chao , Jiao Lin-Yu
Published: January 2025

An efficient Fe–Ru/γ-Al2O3 relay catalyst was developed to promote the three-component reaction of biomass derived α-hydroxy acids and 2,5-dimethoxytetrahydrofuran with 2-nitroaromatic amines.
Reaction mechanism of atomic layer deposition of zirconium oxide using tris(dimethylamino)cyclopentadienyl zirconium: experimental and theoretical study
Authors: Kim Hye-Lee , Kim Okhyeon , Sriwijaya Yong Richard , Khumaini Khabib , Hidayat Romel , Lee Won-Jun
Published: January 2025

The reaction mechanism of ALD of ZrO2 using CpZr(NMe2)3 was investigated through the integration of QCM analysis and DFT calculations.
Engineering porous poly-ionic liquids via a soft template approach: novel carrier for robust incorporation of phosphomolybdic acid for oxidative desulfurization
Authors: Tong Shuang , Gao Yongkang , Huang Tianqi , Chen Mengyue , Zhu Zidan , Li Hongping , Wang Chao , Li Huaming , Zhang Ming
Published: January 2025

Construction of PIL(P123)-PMA with robust and uniform loading of catalytic active centers for improved oxidative desulfurization performance.
Ligand-enabled enantio- and site-selective remote C–H arylation of 2-(2-phenpropyl)pyridine derivatives
Authors: Li Dai-Yu , Li Jin-Ping , Yabu Shunsuke , Wang Li-Sheng , Sato Hirofumi , Higashi Masahiro , Kuninobu Yoichiro , Li Hong-Liang
Published: January 2025

A ligand-enabled enantio- and site-selective functionalization of remote C–H bonds (γ-C(sp3)–H and δ-C(sp2)–H bonds) of 2-(2-phenylpropyl)pyridine derivatives via six- and seven-membered palladacycles was developed.
Cu/Cu2O/NH2-MIL-88B (Fe) heterojunction as the photocatalyst to remove hexavalent chromium heavy metal ions in water
Authors: Xu Chunhua
Published: January 2025

Cu/Cu2O/NH2-MIL-88B (Fe) heterojunction material under the condition of pH = 2, ethanol as a sacrificial agent, dark adsorption for 60 min, photocatalytic reduction for 150 min, the photocatalytic adsorption reduction rate of Cr(vi) was 96.3%.
Eliminating water molecules through tailored crystal orientation to enhance the lithium storage capacity of iron oxalate
Authors: Gao Geng , Tang Jian , Zhang Shaoze , Jin Bo , Yuan Yajie , Zeng Yixing , Xu Yanqiu , Zhao Qing , Zhang Keyu , Hu Junxian , Li Yin , Yao Yaochun
Published: January 2025

Iron oxalate, a coordination polymer known for its sustainability, is a potential candidate for high-capacity and high-rate anode materials for lithium-ion batteries.
Artificial interface engineering to achieve high-performance garnet-based solid-state lithium metal batteries
Authors: Yuan Yingyi , Liu Qiwei , Ji Chuang , Xiang Zhifeng , Feng Shihao , Xiong Xunhui
Published: January 2025

LLZTO@Li–Sn/LiCl-assembled symmetric cells can operate over 6000 h at 0.2 mA cm−2.
Morphology and doping engineering of sulfur-doped g-C3N4 hollow nanovesicles for boosting photocatalytic hydrogen production
Authors: Zhang Zifan , Song Changhui , Fan Jipeng , Fang Zhijie , Wang Haitao , Zou Jing
Published: January 2025

Based on a supramolecular self-assembly strategy, an advanced sulfur-doped hollow g-C3N4 nanovesicle (HV-SCN) is developed successfully for efficient photocatalytic H2 evolution.
Value Added by Assessing Nonspoken Vocabulary in Minimally Speaking Autistic Children
Authors: MacDonald-Prégent Angela , McGuinness Lauren , Nadig Aparna
Published: January 2025

Purpose:

There is a scarcity of language assessment tools properly adapted for use with minimally speaking autistic children. As these children often use nonspoken methods of communication (i.e., augmentative and alternative communication [AAC]), modification of traditional assessment tools is needed to capture the full range of their communicative repertoires. We modified the MacArthur–Bates Communicative Development Inventories (CDI) to explore how vocabulary size and composition are impacted by considering nonspoken, as well as spoken, expressive vocabulary (AAC-modified CDI: Words and Gestures).

Method:

Our initial sample consisted of 16 minimally speaking autistic children, 3–9 years old, whose caregivers completed our modified CDI after taking part in an AAC intervention. Our final sample included 15 participants, after removing an outlier.

Results:

Accounting for both spoken and nonspoken communication significantly increased participants' reported expressive vocabulary by an average of 14 words (
z =
−2.61,
p
= .009,
r
= .75). Verbs made up a sizable portion (13.3%) of vocabulary when accounting for all modalities, while nouns made up the majority (51.5%).

Conclusions:

We demonstrated the value of including both spoken and nonspoken modalities of communication when assessing the expressive vocabulary of minimally speaking autistic children. Prior work has shown that minimally speaking autistic children's spoken vocabulary was prominent in verbs (i.e., contained proportionally more verbs than that of vocabulary-matched typically developing children). In our sample, which used a broader definition of minimally speaking, we found that the proportions of verbs and nouns were consistent with what has been reported for typically developing children with similar-sized productive vocabularies.
Statistical approach to deadband estimation to inform TESS energy specification
Authors: Hu Yiheng , Schofield Nigel , Zhao Nan
Published: January 2025

The increasing use of renewable energy and decreasing inertia from large generators necessitate studying transient energy storage systems (TESSs) for better frequency stability. This paper examines UK National Grid data from 2014 to 2022 to propose initial design requirements for a TESS power‐train. It assesses second‐by‐second historical frequency data across various time frames to explore the impact on TESS sizing and strategies using the enhanced frequency response service 1 approach. The results establish an approach for determining the suitable battery energy capacity of TESSs offering frequency control services, contributing to the reduction of power demand and energy losses in the distribution grid. Moreover, the study presents a suitable deadband strategy for the enhanced frequency response service. The findings provide insights into the design and operational needs of TESSs in supporting grid frequency response, utilizing a statistical methodology driven by frequency data from the UK transmission network managed by National Grid Electricity Transmission. The primary aims of the paper are (a) to develop a suitable power and energy management philosophy for TESSs and thus inform future control objectives, and (b) assess the system energy specification requirements.
Dual-component stellar assembly histories in local elliptical galaxies via MUSE
Authors: Jegatheesan Keerthana , Johnston Evelyn J. , Häußler Boris , Lassen Augusto E. , Riffel Rogério , Chies-Santos Ana L.
Published: January 2025

Elliptical galaxies often exhibit complex assembly histories, and are presumed to typically form through a combination of rapid, early star formation and the subsequent accretion of material, often resulting from mergers with other galaxies. To investigate theories of spheroidal galaxy formation, the objective of this work is to analyse the star formation histories (SFHs) of a sample of three isolated elliptical galaxies in the local Universe observed with MUSE at z < 0.06. With BUDDI, we decompose the integral field unit (IFU) datacubes into two components with Sérsic profiles, which roughly correspond to the two phases of in situ and ex situ star formation. To constrain the mode of growth in these galaxies, we derived the mass and light-weighted stellar ages and metallicities, and created 2D stellar population maps of each component using pPXF. We reconstructed the mass and light-weighted SFHs to constrain the contribution of different stellar populations to the mass and luminosity of the components through cosmic time. Our results show that the ellipticals in this sample have experienced an early and rapid phase of star formation, either through a rapid dissipative collapse or gas-rich major mergers concentrated in the inner component, which contributes to ∼50% of the galaxy stellar mass. The co-dominant outer component, however, had assembled the bulk of its stellar mass shortly after the inner component did, through accretion via dry mergers and possible gas accretion. This premise is supported by our observations of the inner component being primarily composed of old and metal-rich stars. The outer component has a combination of old and intermediate-age stars, with a moderate spread in metallicities. These results are analysed through the lens of the two-phase scenario, a framework developed over the years to explain the formation histories of elliptical galaxies.
ASTRAEUS
Authors: Hutter Anne , Cueto Elie R. , Dayal Pratika , Gottlöber Stefan , Trebitsch Maxime , Yepes Gustavo
Published: January 2025

Context. The James Webb Space Telescope (JWST) has uncovered an abundance of z > 10 galaxies bright in the ultraviolet (UV), whose presence poses a challenge to traditional theoretical models at high redshifts. Various new models have recently emerged to address this discrepancy by refining their description of star formation.

Aims. Here, we investigate whether modifications to the stellar initial mass function (IMF) alone can reproduce the z > 10 UV luminosity functions (UV LFs) when the star formation rate is used as a proxy for the fraction of massive stars.

Methods. We incorporated an evolving IMF into the ASTRAEUS galaxy evolution and reionisation simulation framework, which becomes increasingly top-heavy as the gas density in a galaxy rises above a given threshold. Our implementation accounts for the IMF’s effects on supernova (SN) feedback and metal enrichment, as well as UV and ionising emissivities.

Results. For this evolving IMF model, we find that (i) the maximum UV luminosity enhancement is twice as large in massive galaxies (ΔMUV ≃ 2.6) than those where star formation is strongly limited by SN feedback (ΔMUV ≃ 1.3); (ii) it successfully reproduces the observed UV LFs at z = 5 − 15; (iii) galaxies with top-heavy IMFs exhibit the highest star formation rates, driven by their location in local density peaks, which facilitates higher gas accretion rates; (iv) the 1σ variances in the UV luminosity are only slightly higher compared to when assuming a Salpeter IMF, but the 2σ variances are significantly increased by a factor of 1.4 − 2 boosting the abundance of UV-bright galaxies at z > 10; and (v) reionisation begins earlier with more extended large ionised regions and fewer smaller ones during its initial stages, although these differences diminish at lower redshifts, leading to a similar end of reionisation at z ≃ 5.6.
Exploration and morphological characterization of
Trichoderma spp from organic waste at TPST Rempoah-Baturraden, Banyumas Regency
Authors: Muljowati Juni Safitri , Oedjijono Oedjijono , Dewi Ratna Stia , Mariana Afifah , Chemeltorit Philip
Published: January 2025

Members of the Trichoderma genera are able to adapt to various habitats including organic waste, with a fairly high population density. This study aimed to determine the differences in the morphological characteristics of Trichoderma spp isolated from the Rempoah Integrated Waste Processing Facility (TPST), Baturraden District, Banyumas Regency. The experiment was conducted at the Mycology and Phytopathology Laboratory, Faculty of Biology, Jenderal Soedirman University. The results of the exploration of the Trichoderma genera obtained three isolates. The characteristics observed were macroscopic characteristics including the colour and shape of the colonies, and microscopic characteristics including the shape of conidiophores, phialides, and conidia. The results showed that the three Trichoderma isolates from Rempoah TPST had different morphological characteristics. The species of Trichoderma spp obtained were T. koningii, T. asperellum, and T. harzianum.
The NaBH4 Reduction and pH Effects on the Optical Property of Bismuth Vanadate
Authors: Riapanitra Anung , Julian Haryanto Michael , Setyaningtyas Tien , Riyani Kapti , Nur Handayani Santi
Published: January 2025

In this study, oxygen vacancies were created on the surface of BiVO4 nanoparticles using the NaBH4 reduction technique, resulting in BiVO4−x samples that are oxygen-deficient. Optical absorption data using a UV-visible diffuse reflectance spectrophotometer showed that the reduction process increases the maximum absorption edge to 575 nm and reduces the band gap energy to 2.78 eV at high pH. Furthermore, modulating pH during synthesis allowed tuning of the electronic structure and surface states of BiVO₄, which significantly impacts the photocatalytic efficiency. Higher pH levels during reduction led to narrower band gaps and enhanced visible-light responsiveness. These vacancies should serve as charge traps and adsorption sites, improving the charge transport within the BiVO₄ matrix by limiting electron-hole recombination. This improves photogenerated electron availability, enabling better pollutant photodegradation and water oxidation potential in environmental applications. The study highlights the role of NaBH₄ as a reduction, effectively creating oxygen vacancies and optimizing photocatalytic performance. This research underscores the potential of engineered BiVO₄ nanoparticles with tailored oxygen vacancies for advanced photocatalytic applications, especially in environmental remediation.
Fruit Leather Melon Formulation with Supplementation of Pineapple Puree, Carrageenan and Sorbitol
Authors: Aini Nur , Nurfadilah Azzahra Salma , Setyawati Retno , Sustriawan Budi , Eko Kusuma Kurniawan Ruly , Sabila Arsyistawa Hadana , Putri Roro Arianti Embun
Published: January 2025

Melon is a fruit with high water content so that processing is needed to increase its economic value and shelf life. An alternative that can be done is to process it into fruit leather. The characteristics of fruit leather are influenced by pectin, sugar, and acid. The purpose of this study was to determine the optimum formula based on the addition of pineapple puree, carrageenan, and sorbitol to the chemical and sensory characteristics of melon fruit leather. The study used Response Surface Methodology with a Central Composite Design. The factors studied were pineapple puree, carrageenan, and sorbitol. The research stages carried out included preliminary research, formulation optimization, data analysis, verification and validation, and characterization of the optimum product. The results showed that increasing the concentration of pineapple puree caused an increase in water content, total sugar, titrated acid, and a decrease in texture sensory, while preferences tended to be stable. Increasing the carrageenan concentration caused an increase in total sugar and texture, but decrease in water content, titrated acid, and preference. Increasing the sorbitol concentration caused an increase in texture and preference, but a decrease in water content, total sugar and titrated acid. The optimum formula obtained of melon fruit leather based on 15% pineapple puree, 0.6% carrageenan, and 8% sorbitol with a desirability level of 0.723. The optimum formula had a water content of 17.9%; total sugar 20.0%; titratable acid 1.6%, which was lower compared to the control. Vitamin C content 52.2 mg/100 g; soluble solids of 83.2 oBrix, colour of 3.9; taste of 3.6, texture of 3.7; and preference 3.8; which were higher compared to the control. While the aroma sensory 3.044 was the same as the control.
Effects of Local Chicken Strain and Phytobiotics Supplementation on Body Weight and the Percentage of Lymphoid Organ Weight
Authors: Ismoyowati  , Tugiyanti Elly , Suswoyo Imam , Darmanto Agus , Agus Santosa Setya
Published: January 2025

Phytobiotics consist of various herbs and their derivatives which are widely used as growth promoters, antimicrobial, anti-oxidative, and other properties. The purpose of this study was to ascertain how the strain of local chickens and phytobiotics interacted with body weight and the percentage of weight in lymphoid organs. A total of 480 birds, comprising Kampung chicken, Kampung unggul Balitbangtan (KUB) chicken, and Kedu chickens, made up the research material. The phytobiotics and basal diet included 1% sambiloto, 1% garlic, and 1% kalimun. A completely randomized design factorial pattern was employed in the experiment. The analysis of variance was used to examine the data. The analysis of variance revealed that there was no significant (p>0.05) impact on the body weight and percentage of lymphoid organ weight of local chickens from the interaction between phytobiotics feeds and local chicken lines. The proportion of thymus and bursa of fabricius weights, as well as body weight, were significantly (p<0.05) impacted by the chicken strain. The local chicken's body weight was significantly affected (p<0.01) by a 1% phytobiotic supplement. Local chickens' body weight and percentage of lymphoid organ weight were not significantly impacted (p>0.05) by the interaction between local chicken strain and phytobiotics diets, according to the analysis of variance results. KUB chickens have a higher lymphoid organ than Kampung and Kedu chickens. Supplementation with 1% sambiloto reduced the body weight of local chickens.
Whole space case for solution formula of Korteweg type fluid motion in R3
Authors: Bagus Suhada Dede , Maryani Sri , Renny Renny , Triyani Triyani , Hendriya Guswanto Bambang , Kartiwi Mira
Published: January 2025

In this paper we consider the solution formula of linearized diffusive capillary model of Korteweg type without surface tension in three-dimensional Euclidean space ℝ3 using Fourier transform. Firstly, we construct the matrix of differential operators from the model problem. Then, we apply Fourier transform to the matrix. In the third step, we consider the resolvent problem of model problem. Finally, we find the solution formula of velocity and density by using inverse Fourier transform. For the further research we can consider not only estimating the solution operator families of the Korteweg theory of capillarity but also estimating the optimal decay for solution to the non-linear problem.
Usability test of the “Denia-IS” mobile application for sustainability high-risk pregnancy early detection in rural areas
Authors: Dwi Anggraeni Mekar , Triyanto Endang , Iskandar Asep , Fatoni Amin , Niyomdecha Najwa
Published: January 2025

Maternal Mortality Rate is one of the Sustainable Development Goals (SDGs) indicators and a major health problem in South East Asia. The majority of maternal mortality cases could be prevented through early detection. The objectives of this study were to examine the usability of Denia-IS. This study used a descriptive research design with respondents from pregnant women in Indonesia rural areas. The inclusion criteria in this study were pregnant women, gestational age 25-38 weeks, having an Android-based smartphone, and being willing to be respondents. The exclusion criteria in this study were a history of chronic hypertension, chronic bleeding, thalassemia, and suffering from malaria. For usability evaluation, 120 respondents were recruited from the outpatient clinic. This study used System Usability Scale (SUS). The response rate was 95% and respondents reported that the app had an excellent usability (mean= 88.73; SD= 0.4). Most of the respondents found that Denia-IS easy to use and would like to use it again. The respondents reported that the system helped them feel in control, and the information was useful. This App has reasonably good usability to asses and communicate high risk during pregnancy in a typically hard-to-reach population and personalized distance obstetrical care in rural areas.
Hepatoprotective effect anti-inflammatory and antioxidant
Ganoderma lucidum ethanol extract on rats exposed to Plumbum acetate
Authors: Hernayanti  , Laksana Agung , Saryono  , Jehloh Latifah
Published: January 2025

Plumbum (Pb) is a toxic heavy metal that pollutes the environment and endangers human health. Pb exposure also induces a hepatic inflammatory response characterized by an increase in TNFα. The purpose of the study was to obtain natural anti-hepatotoxic compounds due to Pb exposure from Ganoderma extract in terms of GST, SOD, GPx, and TNF α levels. This research was conducted experimentally with a Completely Randomized Design consisting of 6 treatments with 4 replications. Twenty-four rats were used in this study and divided into six groups with four replications. Group 1 was the healthy control, and group 2 was the sick control induced by a Pb acetate dose of 0.5 mg/kgBB. Groups 3, 4, and 5 were induced by Pb acetate and given ethanol extract of
G.lucidum at a dose of 250 mg/kgBW, 500 mg/kgBW, and 750 mg/kgBW for 14 days. The parameters studied include GST, TNFα, SOD, and GPx levels. Data were analyzed by the ANOVA test and continued with Duncan's test.
Ganoderma lucidum is anti-hepatotoxic in terms of GST levels, anti-inflammatory in terms of TNF alpha levels, and antioxidant in terms of SOD and GPx levels. A dose of 500 mg/kgBW is a dose that can overcome the inflammatory effects of free radicals and hepatotoxic effects due to Pb exposure.
Analysis of the Effectiveness of Hydrogel Based on Patikan Kebo Leaf Extract and Honey in Therapy of II Degree Burns
Authors: Winda Puji Lestari Roro , Khorinnisa Hayatul , Nurtiara Alma , Lita Septiana Enggel , Yuliyanti Dwi , Nur Handayani Santi
Published: January 2025

Treatment of burns such as using toothpaste, butter, oil, and ice is less effective in treating burns. A safer and more effective alternative is needed as a dressing for burn wounds. The use of burn wound coverings with the moist wound healing principle is recommended because they are flexible, elastic, and support the burn wound healing process. Patikan kebo leaves contain flavonoids, tannins, alkaloids, saponins, and terpenoids which function as antibacterial and anti-inflammatory in the healing process of second-degree burns. This research aims to make a hydrogel from patikan kebo leaf extract with honey and tests its antibacterial and anti-inflammatory effectiveness as a treatment for second-degree burns. The method used is synthesis hydrogel, antibacterial and anti-inflammatory tests, and continued testing using histopathology tests. The antibacterial test results showed that the extract didn’t show better activity than the positive control on
Escherichia coli bacteria, while the F4 sample showed the best antibacterial effect on
Streptococcus aureus bacteria. Anti-inflammatory and burn healing test seen from the results of histopathology tests produced the best percentage of burn wound healing in sample F4.
Valuing Banyumas Cultural Heritage Tourism: A Comparative Analysis in Support of SDG’s 11 for Sustainable Cities and Communities
Authors: Suharno Suharno , Aziz Ahmad Abdul , Lestari Unik , Eltayeb Elfaki Khalid
Published: January 2025

The study of the economic valuation of cultural heritage tourism has a long history and has gained renewed interest in recent years. This paper poses a methodological challenge in using alternative scales to monetary ranges for cultural heritage valuation. A famous Banyumas cultural tourism site is taken as a case study, and the site's utility is estimated through the method of travel cost (monetary value) and time spent visiting the site (non-monetary scale). According to consumption theory, this study finds an inverse relationship between the two scales and demand intensity. While the monetary approach mainly reflects the cost of accessing cultural heritage tourism –
ceteris paribus preference– the time spent approach shows that those who invest more time in the visit are fanatics, avid enthusiasts, fascinated visitors, engagement visitors, and educated adults. These results provide more efficient policy implications in cultural tourism management and market valuation. This aligns with Sustainable Development Goal (SDG) 11's objectives, which encourage making cities and human settlements inclusive, safe, resilient, and sustainable. By evaluating cultural heritage through monetary and non-monetary methods, this study supports the development of tourism policies that enhance visitor satisfaction and prioritise the sustainable management and preservation of cultural sites for future generations.
The Role of Resource Management on MSMEs Financial Performance: Supporting SDG 8 - Decent Work and Economic Growth
Authors: Shaferi Intan , Nawarini Alisa Tri , Setyanto Refius Pradipta
Published: January 2025

This research examines that resource management is an element of MSMEs financial performance, closely tied to achieving sustainable economic growth as outlined in SDG 8. Economic performance is the center of MSMEs' success, and to contribute to the broader goals of decent work and economic growth, entities need to explore and maximize the function of resource management to generate income. Research was conducted on a hundred MSMEs in the Banyumas and Purbalingga areas. Data was collected using questionnaires, and the analytical tool used is SEM-PLS. The research results show that resource management positively affects MSMEs' financial performance. In other words, the support of the internal system within the entity will guide MSMEs to have better income in dynamic economic conditions, thus contributing to the achievement of SDG 8 by promoting sustainable and inclusive growth.
Policy recommendations for community empowerment in climate change adaptation: A study of the Go Green Pandawara Group campaign in Support of SDG 13 Climate Action
Authors: Harmono Fendi , Nurhamzah Fachrizal
Published: January 2025

This research aims to formulate policy recommendations for community empowerment in facing climate change through a case study of the Go Green campaign conducted by the Pandawara Group in alignment with SDG 13: Climate Action. This campaign focuses on raising public awareness about the importance of climate change adaptation efforts through concrete actions such as reforestation, waste management, and carbon footprint reduction. The method used in this research is a qualitative approach with case study analysis. Data were collected through interviews, observations, and documentation of campaign activities. The study results show that the Go Green campaign by the Pandawara Group successfully encouraged active community participation in various environmentally friendly programs. However, there are challenges to the program's sustainability, particularly related to long-term commitment and more robust policy support from the government. Therefore, this research provides several policy recommendations, including strengthening collaboration between the government, communities, non-governmental organisations, and the private sector and integrating climate change adaptation programs into regional development plans. Implementing these policies is expected to strengthen the community’s capacity to face the impacts of climate change.
SDG 5 and Local Action Plan Challenges on Protection and Empowerment of Women and Children in Central Java’s Social Conflicts
Authors: Sabhita Kusuma Ayusia , Adi Setyorini Fitri , Ramadhanti Wita , Murniati Tri , Huda Marwan Nurul
Published: January 2025

The 2000 UN Security Council Resolution 1325 on Women, Peace, and Security was adopted in Indonesia through the National Action Plan for the Protection and Empowerment of Women and Children in Social Conflict (NAP P3AKS). At a local level, RAN P3AKS was adopted through Local Action Plan (LAP) P3AKS issued by six regions in Indonesia, namely Lampung, Aceh, Central Sulawesi, East Java, DIY, and Central Java. Central Java Province has issued LAP P3AKS through Central Java Governor Regulation Number 51c of 2023 concerning the Action Plan for the Protection and Empowerment of Women and Children in Social Conflict in Central Java 2023-2027. Through this research, the team intends to elaborate on the challenges in formulating and implementing the LAP to protect and empower women and children in Central Java. This research uses a qualitative research type with a case study approach. Data were collected through observation, in-depth interviews, and literature studies. This study's findings show several challenges in formulating and implementing LAP P3AKS in Central Java. Namely, there were differences in perception by local apparatus organisations, no disaggregated data on social conflicts, lack of budgeting and coordination of local government, and inactive participation.
Susceptibility of German Cockroach,
Blattella germanica to Organic Insecticides Based on The Entomopathogenic Fungi
Beauveria bassiana
Authors: Lidiya Putri Siti , Mumpuni Aris , Basar Ida Simanjuntak Sorta , Muflihah Yulianti Dwiana , Abdalla Mohammed , Budi Ambarningrum Trisnowati
Published: January 2025

German cockroaches have been reported to have developed resistance to 42 active insecticide ingredients. An effort to minimize the development of resistance in German cockroaches is to use organic insecticides, one of which is a secondary metabolite from the entomopathogenic fungus Beauveria bassiana (B10). The purpose of this study was to determine the susceptibility of German cockroaches to the organic insecticide B10, which contains secondary metabolites of B. bassiana. This study used an experimental method with a completely randomized design consisting of ten treatments, namely concentrations of 0, 0.1, 0.5, 1, 5, 10, 20, 30, 40, and 50% (v / w). Each treatment unit used ten male German cockroaches which were repeated three times. Mortality data were analyzed using ANOVA followed by Duncan's test at a significance level of p <0.05. The results showed that the application of organic insecticide B. bassiana B10 was quite effective in controlling German cockroaches as indicated by the mortality of German cockroaches. The application of B. bassiana B10 secondary metabolites causing the mortality of German cockroaches with a concentration of 40 % with a mortality percentage of 50%.
Environmental Contribution to the Effectiveness of Food Security Policy Implementation as A Rehabilitation Effort for Stunting Treatment in Rokan Hilir Regency
Authors: Yuliani Febri , Sulistyani Andri , Yusrizal Firdaus
Published: January 2025

According to SDGs 2030, food security must have 3 principles, namely; Availability, Affordability; and Benefits, hereinafter referred to as food security aspects. Rokan Hilir is an area with a high level of stunting. Referring to the problem formulation, the objectives of this research are: 1) to analyze and describe the effectiveness of the implementation of the Food Security Policy; 2) to analyze and describe the factors which constrain the effectiveness implementation the Food Security Policy in Rehabilitation Efforts to Handle Stunting in Rokan Hilir. A qualitative approach is taken by using descriptive analysis methods. Informants are including people and parties who are dealing to the food security policy innovations in handling stunting including local government staff, the community and non-government organization (NGOs). The research results show that stunting in children will have an impact on metabolic disorders, low immunity, and suboptimal physical body size. A good coordination and communication among the parties is a key of success to prevent higher cases and develop community awareness of stunting.
The Impact of Peatland Damage and Its Influence on Food Security Policy in Sungai Apit Sub-District in 2023
Authors: Albintani Muchid , Susanto Agus , Zebua Ben Hansel Notatema , Wasillah Asiah , Harirah Zulfa
Published: January 2025

The deterioration of peatlands will have a considerable impact on food security, which is of strategic importance with regard to social resilience, economic stability, political stability, national resilience, and national independence. This research project has the following objectives: (1) to identify food security policies and peat management policies in the Sungai Apit District; (2) to analyze the impact of peatland damage on food sustainability in the Sungai Apit District; and (3) to analyze the relationship between food security policies and peat management in the Sungai Apit District. This research employs the “Triple Helix” theory, as proposed by Etzkowitz and Leydersdorff (1995). The triple helix model is a qualitative research method that describes social behavior in society aimed at creating cooperative synergies between three key actors: academia (A), business (B), and government (G). The findings of this study indicate that the degradation of peatlands in Sungai Apit District has a detrimental impact on agricultural productivity, the incidence of environmental disasters, the quality of water sources, soil degradation, biodiversity loss, climate change, and socio-economic consequences. By implementing a triple helix collaboration policy, it is possible to achieve food sovereignty, which entails engaging the academic, business, and government sectors, particularly to enhance the accessibility, affordability, consumption, and nutritional value of food in Sungai Apit District.
Community Social Capital and Farmer Development: Key Drivers of Welfare and Business Productivity in Farmer Groups
Authors: Suryalena Suryalena , Andri Seno , Karneli Okta , Andini Frini Karina , Febrian Achmad Fajri
Published: January 2025

Community Social Capital and farmer characteristic development are seen as important factors that can influence farmer welfare and farming productivity in farmer groups. This study aims to analyze the influence of Community Social Capital and farmer characteristic development on farmer group welfare and business productivity. This study uses a quantitative method with a survey approach, with 35 respondents who are members of farmer groups in Dayun District, Riau Province. Data were collected using a questionnaire that includes the variables Community Social Capital, farmer welfare, farmer characteristic development, and farming productivity. Data analysis was carried out using path analysis through Structural Equation Modeling-Partial Least Square (SEM-PLS). The results showed that Community Social Capital and farmer characteristic development have a significant positive influence on farmer welfare and farming productivity in farmer groups. This indicates that increasing community social capital and developing farmer characteristics, such as knowledge, skills, and innovation, can contribute to improving welfare and agricultural production. This study highlights the importance of the role of Community Social Capital and the development of farmer characteristics in improving welfare and productivity of farming businesses.
Empowering communities through social learning: Enhancing engagement in waste management at Mandiri Kasturi
Authors: Fajri Hidayatul , Saputra Boni , Pegi Andre Lofika , Renaldi Irfan , Halawa Historis Soterman , Wahyuni Nila
Published: January 2025

A clean and healthy environment is a crucial element in the well-being of society. However, waste management in many areas, including Mandiri Kesturi, remains a significant challenge, especially amid rapid urbanization and population increase. This research explores how community-based approaches and “social learning” can improve community engagement in waste management. By involving the community in sorting to recycling, this approach improves waste management efficiency and creates sustainable environmental awareness. This case study uses a descriptive qualitative method in the Mandiri Kesturi community, with participants from community members and local leaders actively participating in the waste management program. The results showed that social learning within the community could optimize participation and create a sense of collective responsibility in maintaining environmental cleanliness. This empowerment model is expected to be applied in other communities facing similar challenges.