bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimizing Model of a Machine-Building Enterprise Output under Demand Uncertainty
Authors: Vorobev M. S. , Vakhrusheva E. N. , Vologdin S. V.
Published: April 2024

The article develops anoptimizing model for a machine-building enterpriseproduction plan, taking into account a combination of factors such as financial capabilities and production capacity of the enterprise, limited resources, as well as demand uncertainty of long-range planning for a period of more than three months. Product features of a machine-building plant is taken into account that produces equipment and spare parts for oil-extraction enterprises, as well as the peculiarities of its operations in the market, due to the capabilityof sales forecasting for 2-3-month periods ahead based on actual demand under tender agreements. And this will be the minimum plan that the production company needs to follow. It is proposed to solve the demand uncertainty by means of adaptive forecasting methods based on statistical data available from thesales enterprise indicatorsof the past periods. It is econometric models ARMA and ARIMA that are designed to analyze time series that do not contain a seasonal component, since the demand for the products of a machine-building enterprise has no seasonal fluctuations. The ARMA model uses a combination of past values and white noise to predict future values and assumes that time series data are stationary, which means their statistical properties will not change over time. The ARIMA model is an extension of ARMA for non-stationary time series and is used to build short-term forecasts in which the lead period ranges from one or several months to a year. The mathematical model is a nonlinear conditional optimization problem. To solve this problem, various methods are proposed, allowing determination the optimal production plan, the minimum loan amount and the resources needed to implement this plan.
To the Derivation of a Mathematical Model of a Chaotic System Using the Example of a Chua Circuit of Fractional Order
Authors: Knyazev I.V. , Ushakov P.A.
Published: April 2024

An analysis of existing mathematical models of a fractional order Chua circuit was carried out, which showed that in all models the fractional order is achieved by replacing the first order derivatives of the system of differential equations that describe the behavior of the classical Chua circuit with fractional order derivatives with some differences in taking into account the parameters and the nature of Chua diode nonlinearity. However, such a replacement has not been justified in any way. The paper considers an approach to form a fractional order Chua circuit, where capacitive elements of a Chua circuit are replaced with specific elements, which component equations represent differential relations of a fractional order (the so-called “elements with fractal impedance”). During preliminary assessment of chaos emergence conditions of the existing fractional order model in MATLAB and its analogue the OrCAD circuit modeling program using element models with fractal impedance, it turned out that the assessment results do not coincide. The hypothesis for the discrepancy between modeling results was the assumption that the mathematical model of a fractional order Chua circuit, obtained by formal replacing the derivative order, does not reflect features of fractal impedance elements and cannot serve as the basis for an analog implementation of a fractional order Chua circuit. A mathematical model of a chaotic system, built on the basis of a fractional-order Chua circuit containing elements with fractal impedance, is obtained. The result comparison of visual observation of chaotic behavior areas of the fractional order Chua system mathematical model described in literature and obtained in this work using the fde_pi12_pc tool in Matlab with a circuit model of the system in OrCAD has been made. It is shown that the percentage of coincidence of the chaos occurrence conditions in the mathematical model in comparison with the circuit model was: with the mathematical model described in the literature - 11.8 %, and with the mathematical model obtained in this work - 97 %. Consequently, the resulting mathematical model corresponds to the circuit model of a fractional-order Chua circuit more accurately.
STICKERS AS CREOLISED TEXT
Authors: Bralnin D. O.
Published: April 2024

The article is devoted to the study of creolised texts, which in recent decades have become, along with traditional texts, one of the key areas of modern linguistics and communication studies. Considerable attention is paid to the study of the ways of interaction between verbal and non-verbal components, as such semiotically complex texts arise in digital spheres and represent a complex unity of linguistic and non-linguistic elements. It is noted that the interaction of the text part, images and other elements creates a unique communicative environment, which can include a sticker as a special kind of creolised text, for the study of which it is effective to apply the methods of hermeneutic approach, which allows us to consider them as a form of expression of emotions and feelings. It is important to emphasise that in online user interaction, where non-verbal feedback is often absent, the study of stickers from the point of view of hermeneutics allows us to reveal how these symbols are used to convey emotional content and how they interact with verbal text to create a complete communicative act. The article considers different interpretations of the term “creolised text”, which allows us to identify their common features and characteristics, as well as to trace the evolution of such a phenomenon, and summarises the types of relationships between verbal and non-verbal codes in this kind of text presented in the works of various researchers. The article supplements the theoretical apparatus of research in the field of communication theory by highlighting a new type of component interaction, namely modal, in the structure of stickers along with complementary and interpretive on the example of the stickerpack for the anniversary of A.S. Pushkin, whichis relevant in the context of the peculiarities of sticker's functioning in modern communication.
Implementation of Third Eye for Blind People Using Ultrasonic Vibrator Glove
Authors: Chaube Damini
Published: April 2024

Abstract: The “Third Eye for Blind People Using Ultrasonic Vibrator Glove”, is designed to help the blind to overcome the lack of visual sense, by using other senses like sound and touch. It uses audio and vibration signals to notify the user about upcoming hurdle. As the distance between glove and obstacle decreases, frequency of both audio and vibration signals increases, Thus the system helps to ease the navigation process for the needy. The system uses Atmega-328 microcontroller, which is a high performance 8-bit AVR RISC-based microcontroller. It has 32KB of ISP flash memory with read-while-write capabilities, as well as 1KB EEPROM, 2KB SRAM. It also has features like, 23 general purpose I/O lines, 32 general purpose working registers and three adjustable timer/counters with compare modes. For sensing the distance. the system uses a HC-SR04, a Ultrasonic Range Finder Distance Sensor Module. The sensor module is designed to measure the distance using the principle of SONAR or RADAR, of using ultrasonic wave to determine the distance of an object.
Efficiency Enhancement in Automotive Catalytic Converters: Recent Developments and Future Directions
Authors: Makwana Vishal
Published: April 2024

Abstract: Catalytic converters are pivotal components in vehicular exhaust systems, tasked with reducing harmful emissions to meet stringent environmental regulations. This paper offers an in-depth examination of the latest advancements and prospective trajectories for augmenting the efficiency of automotive catalytic converters. Through a survey of contemporary research and industry practices, we explore novel catalyst formulations, innovative design methodologies, and operational strategies aimed at bolstering conversion efficiency and curbing emissions of pollutants like nitrogen oxides (NOx), carbon monoxide (CO), and hydrocarbons (HC). Additionally, we scrutinize emerging technologies, including nanostructured catalysts and catalytic coatings, alongside advanced exhaust gas treatment systems, all poised to revolutionize catalytic converter performance. Furthermore, we address key challenges in efficiency optimization, such as catalyst durability, thermal management, and regulatory compliance, underscoring the need for comprehensive solutions. By synthesizing these insights, our paper not only encapsulates the current state-of-the-art in catalytic converter technology but also charts a course for future research endeavors, aiming for ever more efficient and environmentally sustainable automotive emissions control.
Python-Based Security Operations Center (SOC) and Forensics Analysis for Incident Cyber Threats
Authors: Muthusamy Dr. P. , V Shanmugam , R Kapilsurya , R Saran Kumar
Published: April 2024

Abstract: The increasing complexity and frequency of cyber threats demand robust solutions for incident detection, analysis, and response. Security Operations Centers (SOCs) play a pivotal role in safeguarding organizational assets by monitoring, detecting, and mitigating cyber threats. This paper presents a Python-based approach for enhancing SOC capabilities and conducting forensics analysis to counter incident cyber threats effectively. Leveraging Python's versatility and extensive libraries, this research proposes a comprehensive framework that integrates various cybersecurity tools and techniques for real-time threat monitoring, incident analysis, and forensic investigation. The proposed solution empowers SOCs to detect and respond to cyber threats promptly while facilitating in-depth forensic examination for post-incident analysis and remediation. Through case studies and evaluations, the effectiveness and efficiency of the Python-based SOC and forensics analysis approach are demonstrated, highlighting its potential to enhance organizational cyber resilience.
Carbon Accounting - An Overview
Authors: N Sukrutha. , Pramila Dr. A. C.
Published: April 2024

Abstract: The research study delves into the evolving field of carbon accounting, highlighting its growing importance in the global and Indian business landscapes for climate change mitigation and sustainable development. By conducting an extensive literature review encompassing empirical studies, case analyses, industry reports, and regulatory developments, the study examines carbon accounting practices among Indian companies, focusing on adoption challenges and the implications for sustainable growth. It outlines the evolution of carbon accounting, emphasizing the need for standardized guidelines and capacity building to improve practices in India. The research underscores carbon accounting's role in promoting environmental stewardship, resource efficiency, and climate change mitigation within the Indian business sector. It points to the opportunities and barriers Indian companies face in leveraging carbon credits, suggesting avenues for future research and improvement to foster sustainable business practices and contribute to global climate objectives. The study reflects on the significance of carbon accounting in navigating the complexities of climate change and sustainable development. It calls for enhanced transparency, standardization, and innovation in carbon accounting practices, advocating for a collaborative approach to drive sustainable transformation in India and beyond. This study on carbon accounting -overview offers valuable insights into the current state of carbon accounting in India, setting the stage for further research and dialogue on advancing sustainable and low-carbon business strategies.
Share Wheels
Authors: Chaudhari Prof. Arpit , Dabhade Vedanti , Deshmukh Vedant , Khapre Jay
Published: April 2024

Abstract: A husbandry a variety of issues comes associated with speedy-fireplace boom in populace one similar primary problem is commercial enterprise visitors and different troubles prompted due to it. It has come a chief problem in severa metropolitan regions. During height hour this visitors is commodity every person has to witness due to the way the current society operates. There are numerous outcomes to the problem but one powerful end result is proportion wheels. Sharewheels is a system wherein automobile possessors will share their in detail possessed vehicle to other tripper travelling on the same course. This will drop the empty seats which might affect in decrease buses on road. The cutting-edge cab sharing system isn't crucial swerved from hack gadget which is also not so effective. This carrier will significantly income folks that travel on identical routes on diurnal base comparable as working human beings, scholars. It'll additionally assist the owner with affordability of electricity cutting the price.
SUPORTE PSICOSSOCIAL EM SITUAÇÕES DE AUTOLESÃO E COMPORTAMENTO SUICIDA
Authors: Arraz Livia Souza , Botelho Aline Sousa , Sousa Wyslanne Melo de , Martins Michelle de Sousa Fontes , Diniz Dalciney Maximo
Published: April 2024

Introduction: Although suicide is a public health issue, preventive and welcoming actions are still little used, however, psychosocial support is essential in situations of self-harm and suicidal behavior. Objectives: The present study aims to present a study on psychological support in cases of suicidal behavior and LAI (intentional self-harm). Method: this is a systematic, descriptive literature review. The Scientific Electronic Library Online (SCIELO), Electronic Journals of Psychology (PEPSIC), LILACS and PubMed databases were used, based on the inclusion criteria: articles related to the topic, with a time limit of 5 years. Discussion: it was observed that psychological support is extremely necessary in cases of LAI, including suicidal behavior, not only for the attempter, but also for the family, who experience and deal with difficult moments like these. Final considerations: It is necessary to use universal, selective and indicated intervention strategies, recommended by governmental and non-governmental organizations as activities that aim to prevent and/or reduce the number of cases of self-harm and suicidal behavior.
Safety in Numbers or Lost in the Crowd? Litigation of Mass Claims and Access to Justice in Ontario
Authors: Chiodo Suzanne
Published: April 2024

Ontario’s Class Proceedings Act [CPA] is 30 years old. In the past three decades, it has inspired similar legislation across Canada and around the world, and its capacity for bringing about social change has been widely acknowledged. But, like all things that mature, some cracks are beginning to show. The certification test under section 5 of the CPA has been made more restrictive by recent legislative amendments. In addition, class action practitioners are starting to recognize that the CPA can be a blunt instrument and that some mass claims are better litigated outside of that context. While smaller claims may find safety in numbers in a class action, larger claims that require more individualized treatment may get lost in the crowd. Outside of the CPA, however, there is minimal guidance in this area, and this can lead to uncertainty and delay. This article proposes a set of informal guidelines for the litigation of mass claims in Ontario, informed by multidistrict litigation in the US and group litigation in England & Wales, as well as the theory and history of mass claims typology. This guidance will reduce uncertainty and delay by facilitating agreement between parties on procedural steps and provide much-needed direction for a growing phenomenon.
Planning Law and Accessibility: Third Party Permit Appeals by Persons with Disabilities
Authors: Chipeur Stephanie
Published: April 2024

A physical obstacle, such as a step at the entrance of a building, is the product of the interplay of regulations that govern what and we build. The human rights complaint process can provide a remedy to people with disabilities when they are excluded from public spaces. But there are limits to what can be accomplished by way of a human rights complaint. Human rights commissions and tribunals are not competent to mediate or adjudicate complaints about accessibility before construction commences, because any alleged discrimination is only hypothetical. But just because human rights law is limited in this way should not mean that people with disabilities must wait to encounter inaccessibility before they can influence what and how we build. Planning law legislation in Canada mandates public consultation and it also gives members of the public the right to contest planning decisions by way of an appeal. For people with disabilities, this would mean challenging development and building permits that have already been issued if the proposed development is not accessible. After a municipality issues a development permit, most jurisdictions in Canada allow for an appeal by a third party. There are also some jurisdictions that also allow for this type of appeal after the municipality issues a building permit. If successful in an appeal, members of the public who are opposed to a project, or some of its aspects, may block construction altogether or require modifications. These appeal processes could offer an opportunity for people with disabilities to have a direct impact on how we construct the built environment. An appeal at the permit stage is a promising complement to a human rights complaint, because it is prospective rather than retroactive.
The Nightingale Court Experiment: Lessons for Access to Justice in a Post-Pandemic World
Authors: Naidu Natasha
Published: April 2024

The literature is yet to consider the contribution of Nightingale Courts to access to justice in England and Wales during the COVID-19 pandemic. Nightingale Courts are courts that have been set up in repurposed buildings, such as town halls, hotels, and theatres, to facilitate socially distanced trials and hearings. I fill this gap by asking: to what extent have Nightingale Courts addressed access to justice concerns during the pandemic, and what lessons do Nightingale Courts hold for access to justice across jurisdictions and in the future? I argue that though costly and complex, Nightingale Courts have helped to prevent a further worsening of delay during the pandemic. Then, I explore the lessons of the Nightingale Court experiment for access to justice across jurisdictions and in a post-pandemic world. I consider Nightingale Courts as an experiment for legal architecture, informal justice, and adaptation and resilience. I conclude that Nightingale Courts have maintained and preserved access to the legal system during a time of crisis and thereby contributed to the resilience of the system.
PENGARUH FDR DAN NPF TERHADAP PROFITABILITAS (ROA) BANK SYARIAH YANG TERDAFTAR DI BURSA EFEK INDONESIA (PERIODE 2018-2022)
Authors: Kharazi Muhammad
Published: April 2024

Abstract: This study aims to determine the effect of Financing to Deposit Ratio (FDR) and Non Performing Financing (NPF) on Return on Assets (ROA) in Islamic banking listed on the Indonesia Stock Exchange (2018-2022 Period). This study uses a descriptive quantitative method with multiple linear regression analysis. The results of the study show that the ratio of FDR and NPF simultaneously influences the ROA of Islamic banking. While the partial results, FDR has a negative and insignificant effect on ROA, for the NPF ratio it has a negative and significant effect on ROA.

Keywords: Financing to Deposit Ratio (FDR), Non Performing Financing (NPF), Return on Asset (ROA).

Abstrak: Penelitian ini bertujuan untuk mengetahui pengaruh Financing to Deposit Ratio (FDR) dan Non Performing Financing (NPF) terhadap Return on Asset (ROA) pada perbankan Syariah yang terdaftar di Bursa Efek Indonesia (Periode 2018-2022). Penelitian ini menggunakan metode Kuantitatif deskriptif dengan alat analisis regresi linier berganda. Hasil penelitian menunjukkan Rasio FDR dan NPF secara simultan berpengaruh terhadap ROA Perbankan Syariah. Sedangkan Hasil secara parsial, FDR berpengaruh negatif dan tidak signifikan terhadap ROA, untuk rasio NPF berpengaruh Negatif dan signifikan ter terhadap ROA.

Kata Kunci: Financing to Deposit Ratio (FDR), Non Performing Financing (NPF), Return on Asset (ROA).
Axiological and Ideological Meaning of the Constitutional Reform that Began in 2020 in Russia
Authors: Baburin S. N.
Published: April 2024

The article discusses the issues of constructing a multipolar world, which can successfully exist only in conditions of harmony of the spiritual meanings of the legal traditions of its constituent peoples. The decisive role of spiritual and moral values that underlie the civilizational cultural and historical self-identification of existing states, and the need to find ways to build moral states of various civilizations are argued. International development can only be built on a solid legal basis that combines the organic constitutional development of national states and the formation of international law on the traditional spiritual and moral principles.
Law and Order at the Junction of the Modern and Postmodern Eras: Review of the Speeches of the International Scientific Conference Fifth Baskin Readings (Saint Petersburg, November 2–3, 2023)
Authors: Razuvaev N. V. , Tarkinskaya A. V.
Published: April 2024

This article provides an overview of the sessions of the sections of the International Scientific Conference Fifth Baskin Readings. It was devoted to the role of law in the era of transition from modernity to postmodernity and modern trends in the development of law and order.
EFFECTS OF VITAMIN E ON COLORECTAL CANCER: A SYSTEMATIC REVIEW OF THE RECENT IN VITRO AND IN VIVO EXPERIMENTAL STUDIES
Authors: Shams Hashim Norul Hasliza , Md Yusoff Nor Adlin , Mohamad Sharlina , Shahpudin Siti Nurfatimah Mohd , Silvaragi Thayvee Geetha Bharathi , Saifuddin Siti Nazmin
Published: April 2024

Colorectal cancer (CRC) is the second leading cause of cancer death worldwide. Although with advanced medical insight and care, patients with late-stage CRC have a poor prognosis due to a lack of efficient therapy. Numerous scientific studies on the effects of vitamin E on cancer have been undertaken over the last few decades, with mixed findings. Thus, the goal of this review was to compile and summarize the data on vitamin E in vivo and in vitro experimental trials. PubMed, Scopus, and Science Direct databases were used for automated search of the literature spanning the period from 2010 to February 2021 using the following keywords: vitamin E or tocopherol or tocotrienol; and colorectal cancer or colorectal carcinogenesis or colorectal tumorigenesis. The findings obtained from the ten selected papers on vitamin E, in both in vitro and in vivo models, exhibited the positive effects of vitamin E on colorectal carcinogenesis, thus, necessitating further research on the notable isomers and metabolites of this compound.
CHEMOPREVENTIVE ACTIVITY OF TWO VARIETIES OF FREEZE-DRIED COCONUT WATER AGAINST CERVICAL CANCER CELLS, HELA.
Authors: Mohamad Ansor Nurhuda , Liyana Ramlee Siti Nur , Mail Mohd Hafiz , Saifuddin Siti Nazmin , Das Murtey Mogana , Che Ahmad Ahmad Munir , Singh Rabindarjeet , Sapuan Sarah , Mohamed Md Azman Bin PKM Seeni
Published: April 2024

Coconut water is considered to be nature’s elixir. It is a refreshing beverage that can quench thirst, and it is consumed as a health tonic, especially by people living in the tropics. As cancer prevalence increases, novel anticancer therapies are urgently needed, and the chemoprevention approach using natural products is gaining research attention. The goal of this study was to evaluate the potential chemopreventive effects of two varieties of freeze dried coconut water (FDCW) against cervical cancer (HeLa) cells. Both the MATAG FDCW and the Aromatic Dwarf (AD) FDCW varieties exerted anti-proliferative activity against HeLa cells with a inhibitory concentration of 100 µg/ml. After 72 h of treatment, observation under an inverted microscope showed typical apoptotic morphological alteration in HeLa cells exposed to MATAG FDCW, and features of both apoptosis and autophagy were observed in HeLa cells treated with AD FDCW. Fluorescence microscopy revealed the presence of condensed chromatin and apoptotic bodies in HeLa cells from both treatments. To evaluate the anti-proliferative activity over a prolonged treatment period, HeLa cells treated with each type of FDCW were incubated for 8 d. MATAG FDCW was able to continuously suppress HeLa cell proliferation for the entire experiment, whereas the effect of AD FDCW was not stable and the suppression effect decreased over time. These results suggest that MATAG FDCW has a better anti-proliferative effect than AD FDCW. However, both FDCW varieties demonstrated positive chemopreventive activity and should be considered as potential novel anticancer therapies.
IONIC DISSOLUTION PROFILES OF COMBINED GONIOTHALAMIN AND BIOACTIVE GLASS 45S5 IN CULTURE MEDIUM OF HUMAN OSTEOSARCOMA SAOS-2 CELLS
Authors: Abu Bakar Siti Aishah , Azhar Nur Asna , Muzamil Mohamad Noor , Zainuddin Rokiah , Nordin Ira Maya Sophia , Manaf Ali Abdul , Sahul Hamid Shahrul Bariyah , Mohd Noor Siti Noor Fazliah , Ahmad Nor Hazwani
Published: April 2024

This study aimed to investigate the combined effects of goniothalamin and bioactive glass (GTN-BG) on human osteosarcoma Saos-2 cells that emphasise the extracellular changes in the cells' growth medium, including pH and ion release profile. The MTT assay was used to examine the effect of a combination dose of GTN-BG on Saos-2 cells in comparison to untreated and treated Saos-2 with bioactive glass (BG), goniothalamin (GTN), and doxorubicin (DOX). The pH of the culture media for Saos-2 cells was recorded using a pH meter. The release profile of several selected ions such as Ca2+, Na+, Mg2+, K+ and PO43- in the complete culture media of Saos-2 cells was measured by ICP-OES. This study demonstrated that the combination of GTN-BG is more potent than GTN in inhibiting the proliferation of Saos-2 cells while leaving the viability of HMSC as a control normal cell unaffected. The presence of BG significantly increased the pH values in the culture medium of Saos-2. The BG and GTN-BG culture medium exposed to Saos-2 cells showed a significant increment of Ca2+ and Na+ ions concentration after 1 to 24 hours of incubation time compared to UT and GTN. The inhibitory effects of GTN in Saos-2 cells were improved when combined with BG, which may result from a better microenvironment. The release of ionic dissolution products from the BG allowed the rise of pHe, which minimised the pHe/pHi ratio, and subsequently affected the progression of the Saos-2 cells.
MOLECULAR TARGETS OF MORINGA OLEIFERA IN CANCERS (IN VITRO AND IN VIVO): A SYSTEMATIC REVIEW
Authors: Sharif Salhab Heba Akram , Ziyad Mustafa Al Shalabi Rolla , Joseph Julia , Abdul Samad Nozlena
Published: April 2024

Cancer is unquestionably the greatest worldwide threat to humanity. With fewer side effects, natural anticancer medicines are the most prevalent. Anticancer benefits of dietary polyphenols could be achieved through carcinogen elimination, cancer cell signalling alteration, antioxidant enzymatic activities, and apoptosis-inducing substances, according to the likely approach to anticancer effects of dietary polyphenols research. This study aims to investigate the apoptosis induction mediated by Moringa oleifera in in vitro and other molecular targets in vivo in all types of cancer studies, as well as to describe the most recent and comprehensive research on antioxidant and anticancer characteristics. The terms "molecular target", "signalling pathway", "apoptosis", "Moringa oleifera extract", "mechanism of action", "cancer", "tumour", "carcinoma", and "melanoma" were used to search four online databases, PubMed, Scopus, ScienceDirect, and Google Scholar, for relevant articles published between 2009 and 2019.
RECENT UPDATE ON ANTI-CANCER ACTIVITY OF GYNURA PROCUMBENS (LOUR.) MERR.
Authors: Mohamed Rafeezul , Vuanghao Lim , Yusmaidie Aziz Mohd
Published: April 2024

Gynura procumbens (Lour.) Merr. is a traditional medicinal herb that is utilised to treat a wide range of illnesses, such as kidney disease, hypertension, eruptive fever, snake bites, migraines, diabetes, and rheumatism. Gynura procumbens was also found to exhibit anti-cancer effects, especially related to cervical, breast, leukemia, and osteosarcoma cancers. Nevertheless, the exact mechanisms of its anti-cancer effects are still under investigation. The aim of this study is to provide updated information on ongoing studies which focused on the benefits of Gynura procumbens herb in preventing various types of cancers. Google and PubMed were explored using the keywords “Gynura procumbens and cancer” by selecting published journals on the anti-cancer effects of Gynura procumbens. This review has highlighted the botanical aspects, chemical constituents, and anti-cancer effects of Gynura procumbens on selected types of cancers as have been reported by previous studies. The study findings have implications on future research which pave way for future clinical usage, either alone or in combination with the currently available medicines in treating cancers.
La lectura y la escritura en la formación de maestros: impacto de un acompañamiento transversal y metodológico en la Universidad Tecnológica de Pereira
Authors: Agudelo Gil María Gladis , Giraldo Henao Leandro Arbey , Correa Aristizábal Gloria Inés , Martínez Botero Sebastián
Published: April 2024

Esta publicación presenta los resultados de una investigación aplicada en la Facultad de Ciencias de la Educación de la Universidad Tecnológica de Pereira, con la pretensión de mejorar la lectura y la escritura de sus estudiantes de licenciatura, en su proceso académico de cuatro años. Se inicia respondiendo la pregunta ¿cómo diagnosticar las competencias en lectura y escritura de estudiantes que ingresan a un programa de licenciatura? Se presentan dos pruebas diseñadas y aplicadas durante la ejecución del proyecto, se comparan entre sí; la segunda actualiza la primera. También se mencionan procedimientos que hicieron posible la evaluación de estas pruebas. Luego se presenta el desempeño, tanto en lectura (niveles de comprensión) como en escritura (cohesión, coherencia y corrección), de los estudiantes que ingresaron en el semestre 2018-1 para empezar su formación. Se hace alusión detallada de las dos estrategias, como apuestas de acompañamiento a los estudiantes en sus procesos y productos de lectura y de escritura: una al interior de las asignaturas, abanderada por su profesor titular correspondiente, y la otra, compuesta por talleres, enfocados a atender las dificultades de los estudiantes en este sentido; sus encargados fueron profesores del área de lenguaje, con vasta experiencia docente en la materia. Posteriormente, se revisa el impacto obtenido, lo cual implicó la comparación de dos diagnósticos de desempeño en lectura y escritura: el obtenido por los estudiantes al ingresar a la Facultad para comenzar sus estudios, y el obtenido por ellos mismos en su último semestre de formación. Por último, se presenta la percepción de docentes y directivos docentes, de cara a la propuesta de acompañamiento en general, lo mismo que su participación a lo largo de su implementación, y por supuesto, sus aportes, recomendaciones y sugerencias para un proyecto de similares condiciones, que pretenda aplicarse en el futuro.
Research progress on meningeal metastasis of lung cancer
Authors: Liang Peiqiang
Published: April 2024

Meningeal metastases (LM) are a common complication of malignant tumors
that progress rapidly and have a poor prognosis. Meningeal metastasis
may be a combination of intracellular and extracellular factors. The
linkage between the C3 signaling pathway and the EGFR ligand regulatory
protein pathway may be one of the reasons why NSCLC patients with EGFR
mutations are prone to brain/meningeal metastasis. Cerebrospinal fluid
cytology is the gold standard for diagnosing meningeal metastases. There
are various clinical treatment options, including chemotherapy,
radiation therapy, immunotherapy, targeted therapy, and so on. The
incidence rate of meningeal metastatic carcinoma is increasing year by
year. This article reviews the research progress in pathogenesis,
diagnosis and treatment of meningeal metastatic carcinoma of lung
cancer.
Long-term Exposure to Methyl Jasmonate Increases Myrosinases TGG1 and TGG2 in Arabidopsis coi1 and myc2,3,4 Mutants
Authors: Yamada Kenji , Mirzaei Mohamadreza , Poormassalehgoo Andisheh , Endo Kaichiro , Dubas Ewa
Published: April 2024

Myrosinase is an enzyme that activates a group of metabolites, namely
glucosinolates, which are involved in the defense against herbivores and
pathogens. In Arabidopsis thaliana, THIOGLUCOSIDE GLUCOHYDROLASE
1 (TGG1) and TGG2 are two myrosinases that accumulate in specialized
myrosin cells of rosette leaves. Here, we show that prolonged exposure
to the wounding hormone methyl jasmonate (MeJA) enhances TGG1 and
TGG2 expression independent of the canonical jasmonic acid (JA)
signaling pathway. We found that airborne MeJA treatment for up to
5-days enhanced both TGG1 and TGG2 gene expression and
their protein levels in Arabidopsis leaves. TGG1 and TGG2
gene expression did not stop in two JA signaling pathway mutants, namely
coi1-16 and myc2,3,4, after 5-days of MeJA treatment,
although other typical JA responses were completely stopped in these two
mutants. FAMA is a transcription factor that participates in the
specification of myrosin cell development, but it does not appear to be
involved in TGG1 and TGG2 gene expression regulation in
the 5-day MeJA treatment, as its expression did not increase. Taken
together, our results suggest the existence of an alternative JA
signaling pathway that is activated by long-term exposure to MeJA.
Ovarian Sertoli-Leydig cell tumor with hyperestrogenism in a postmenopausal woman: A case report and review of the literature
Authors: Lu Yujuan , Wang Yu , Yang Yunpeng , Chen Jing
Published: April 2024

【Abstract】Ovarian Sertoli-Leydig cell tumors (SLCTs) are extremely
rare ovarian sex cord-stromal tumors, predominantly secreting
testosterone and occasionally manifesting with elevated estrogen levels,
such as abnormal uterine or postmenopausal bleeding. This report details
a 57-year-old postmenopausal woman with vaginal bleeding. Laboratory
findings indicated mildly suppressed follicle-stimulating hormone and
elevated estradiol. Female tumor markers showed no abnormalities. The
transvaginal ultrasound revealed thickened endometrial lining
accompanied by cystic echoes, cystic echoes in the left ovary, and no
definitive mass observed in the right ovary. Postoperative pathology
revealed atypical endometrial hyperplasia, a serous cystadenoma in the
left ovary, and a moderately differentiated SLCT in the right ovary.
Surgical approach: Total hysterectomy, bilateral adnexectomy, and
omentectomy were performed laparoscopically. Five months
postoperatively, the patient’s follicle-stimulating hormone levels were
significantly elevated, and estradiol levels markedly decreased.
Transvaginal ultrasound showed no occupying lesions in the pelvic
cavity. This case underlines the importance of recognizing elevated
hormone levels as potential indicators of SLCTs when imaging is
inconclusive, highlighting the need for early detection and treatment.
The Impact of Learning rate on Backpropagation Algorithm in Matlab
Authors: Shaikh Abdul Ghafoor , Shaikh Wajid Ali
Published: April 2024

Artificial Neural Networks (ANNs) are highly interconnected. Backpropagation is a common method for training artificial neural networks to minimize the objective function. This study describes the implementation of the backpropagation algorithm. The different errors generated at the output are fed back to the input, and the weights of the neurons are updated by different supervised learning rates, which is a generalization of the delta rule. A sigmoid function was used as the activation function. The design was simulated using MATLAB R2018a. The maximum accuracy was achieved 0.9988 with four hidden layers
Use of an internal loop airlift bioreactor to produce polyhydroxyalkanoates by Stenotrophomonas rhizophila
Authors: Clifton-García Berenice , Villafaña-Rojas Juan , González-Reynoso Orfil , Robledo-Ortiz Jorge , Manríquez-González Ricardo , Gutiérrez-González Porfirio , González-García Yolanda
Published: April 2024

Airlift-type bioreactors present advantages over conventional systems such as
efficient mass transfer, simplicity of construction and low energy
consumption. Thus, they are a good alternative for the production of
polyhydroxyalkanoates (PHAs) nevertheless, their use for that purpose has
been barely studied. This work addresses the design, construction and
hydrodynamic characterization of a 2.4 L internal loop airlift bioreactor,
evaluating the effect of the air flow, liquid volume, and disperser
position, on the interfacial area and the mixing time. Then, it was used for
the fed-batch production of PHB by Stenotrophomonas rhizophila from sugar
cane molasses. It was found that the conditions to increase the interfacial
area and and minimize the mixing time were: airflow, 1.5 vvm; liquid volume,
2400 mL; and disperser position, 5 mm (distance between the air disperser
and the drag tube). Under that configuration, the maximum biomass
concentration, PHB production, and PHB accumulation achieved (54 h of
culture) were: 65.4 g/L, 39.9 g/L, and 60.2 % (g of PHB/100 g dry biomass).
The polymer was poli-3-hydroxybutyrate, with a melting temperature of 170?C,
crystallinity of 56.4 %, and a Mw of 735 kDa.
Costs of Public Auditor Oversight: Real Earnings Management and Innovation Loss
Authors: Lamoreaux Phillip T. , Myers Noah M. , Snow Mason C.
Published: April 2024

Prior research documents positive effects of PCAOB oversight on reporting and audit quality. However, to have a clear understanding of the net benefits of regulation, it is important to also investigate corresponding costs. To this end, we investigate the relation between PCAOB inspection oversight and real earnings management, a potentially value-destroying activity. We exploit the staggered timing of foreign governments’ allowance of PCAOB inspections in a generalized difference-in-differences design and find that companies engage in greater REM after the introduction of PCAOB inspection oversight. This relation is stronger for companies with a reduced ability to manage earnings via accruals. Lastly, we find a negative association between PCAOB oversight and innovation, particularly for firms making larger discretionary cuts to R&D expenditures. Collectively, our findings document unintended consequences of auditor regulatory oversight.

JEL Classifications: G38; M41; M42; M48.
Leveraging Emerging Cybersecurity Reporting Regulations: The Effect of Industry Driven Expectations for Voluntary Assurance
Authors: Navarro Patricia , Sutton Steve G.
Published: April 2024

SYNOPSIS

As the associated costs, business impacts, and high variability of cybersecurity disclosures capture the attention of regulators, we are witnessing a rapid emergence of proposals for new reporting requirements, such as recent SEC proposed disclosure guidelines and legislation being passed in both the EU and U.S. Within the context of cyber-breach disclosure, this study investigates how voluntary assurance provided by professional accounting firms affects nonprofessional investors’ judgments and decisions after the disclosure of a cybersecurity breach—an inevitable event. The study also examines how value relevance of voluntary assurance is altered when having such assurance is expected/unexpected given the company’s industry. We find expectancy violations, based on industry norms and investors’ perceived benefits of voluntary assurance, significantly influence investors’ judgments. This study begins to address questions on whether demand exists for voluntary assurance provided by professional accounting firms, particularly given lingering concerns over the viability of new forms of assurance.

Data Availability: Data are available from the authors upon request.

JEL Classifications: M41; M42; O31; O33.
Actuales tendencias globales sobre estrategias para el fomento de habilidades de emprendimiento en estudiantes de educación secundaria y superior
Authors: Arias Camarena Juan Alberto , Colque Quispe Lucio Wilfredo
Published: April 2024

La promoción de habilidades emprendedoras desde la etapa estudiantil es crucial para el desarrollo económico, ya que garantiza el crecimiento del tejido empresarial del país. Por esta razón, varios Estados de la región han destinado recursos educativos para cultivar estas habilidades en estudiantes universitarios y de secundaria con el propósito de integrarlos en el progreso nacional. En otras palabras, la educación emprendedora fomenta actitudes y comportamientos creativos entre los estudiantes, lo que sirve para optimizar su capacidad para desenvolverse en un entorno empresarial. Explicado lo anterior, el objetivo de este estudio es investigar las estrategias utilizadas para promover dichas prácticas en estudiantes de educación secundaria y superior. Para ello, se realizó una revisión sistemática utilizando la base de datos Scopus. Tras aplicar criterios de inclusión y exclusión, se identificaron 19 artículos publicados entre 2015 y 2023. Los resultados indican que el 52.6 % de las estrategias para fomentar habilidades emprendedoras se basan en el currículo regular, mientras que el 15.8 % se apoya en actividades extracurriculares. Asimismo, se observa una tendencia en la educación secundaria hacia el desarrollo de actividades extracurriculares como centros escolares de negocios, talleres de emprendimiento y prácticas preprofesionales, mientras que en la educación superior las estrategias incluyen incubadoras de emprendimiento y voluntariados.
Enhancing Mini Greenhouse Design: A CFD Analysis of Temperature, Humidity, and Wind Flow Distribution
Authors: Putri Irriwad , Aldi Rahmah Tasya , Hasan Ashadi
Published: April 2024

Research has been carried out on simulating the distribution of temperature, humidity and wind direction in a mini greenhouse using CFD ansys with several fan speed variations. This study aims to simulate the microclimate in a mini greenhouse, namely in the form of temperature, humidity and wind direction with variations in fan speed, namely with speeds of 1.7 m/s, 2.0 m/s and 2.2 m/s. Field measurement data regarding temperature, humidity (RH) in the tunnel-type mini greenhouse that has been carried out is used as input or input to the boundary conditions in the CFD mini greenhouse simulation. The results of the mini greenhouse CFD simulation using Ansys FLUENT are shown in the form of contour images of each condition. Temperature distribution contour, the humidity distribution contour (RH) and the airflow velocity distribution contour indicated by the vector will be used as the focus of this research. The numerical simulation shows quite good results when compared with the results of measurements in the field with the maximum error value obtained, which is 4.04%. Keywords: Computational Fluid Dynamics, Humidity, Simulation, Temperature, Wind direction.
Optimization of the upgrading process of bio-oil from palm fronds: The effect of temperature, catalyst mass ratio, and reaction time
Authors: Sihombing Junifa Layla , Pulungan Ahmad Nasir , Simanjuntak Janter Pangaduan , Hasibuan Muhammad Irvan , Efiyanti Lisna , Rahayu Rahayu , Audi Ajeng Asri , Hadi Muhammad
Published: April 2024

The lignocellulosic component contained in palm frond waste has potential as an alternative fuel by converting it into bio-oil through a pyrolysis process. However, bio-oil has poor quality when compared to conventional fuels. Therefore, the Hydrodeoxygenation (HDO) process has been widely developed as a promising way to improve the poor physicochemical properties of bio-oil. In this study, a bimetallic CuO-ZnO catalyst loaded on mordenite zeolite was used as a catalyst for HDO bio-oil from palm fronds. Optimization efforts were made on several parameters that affect the reaction including temperature, catalyst mass, and reaction time. This study aims to improve the quality of bio-oil and determine the effect of variations in reaction parameters on the physicochemical properties of upgraded bio-oil. The optimum condition found was the HDO process with a catalyst mass of 3.5 wt% at 325 °C for 120 min. The physicochemical properties of bio-oil after the upgrading process were successfully improved from those of raw bio-oil. The result is a decrease in water content and total acid number, an increase in C and H content accompanied by a reduction in oxygen content with a degree of deoxygenation reaching 72.9%, and an increase in higher heating value (HHV).
Enhancing the thermal properties of paraffin wax as latent heat storage material using hybrid nanomaterials
Authors: El-Sebaii A. A. , Aboul-Enein S. , Ramadan M. R. I. , Samy N. , El-Sayed A. R. , Shalaby S. M.
Published: April 2024

Paraffin wax is the most common phase change material (PCM) that has been broadly studied, leading to a reliable optimal for thermal energy storage in solar energy applications. The main advantages of paraffin are its high latent heat of fusion and low melting point that appropriate solar thermal energy application. In addition to its accessibility, ease of use, and ability to be stored at room temperature for extended periods of time, Nevertheless, improving its low thermal conductivity is still a big, noticeable challenge in recently published work. In this work, the effect of adding nano-Cu2O, nano-Al2O3 and hybrid nano-Cu2O-Al2O3 (1:1) at different mass concentrations (1, 3, and 5 wt%) on the thermal characteristics of paraffin wax is investigated. The measured results showed that the peak values of thermal conductivity and diffusivity are achieved at a wight concentration of 3% when nano-Cu2O and nano-Al2O3 are added to paraffin wax with significant superiority for nano-Cu2O. While both of those thermal properties are negatively affected by increasing the concentration beyond this value. The results also showed the excellence of the proposed hybrid nanoparticles compared to nano-Cu2O and nano-Al2O3 as they achieve the highest values of thermal conductivity and diffusivity at a weight concentration of 5.0 wt%.
Pompan: A bread production alternative using apple pomace
Authors: Coelho Beatriz , Oliveira Inês , Mota Isabel , Nunes João , Coelho Sofia , Mendes Tiago
Published: April 2024

This work consists of developing a product that uses apple leftovers. The product selected was bread baked with a flour mixture of 5% (by mass) apple flour to wheat flour. Besides providing an easy-to-use solution for leftovers, this mixture also provides a higher fiber content to the food. After the process was designed, it was concluded that producing 5.4 million breads per year with about 23 tons of apple pomace was possible. In the end, the economic analysis was done, and the process should return a profit at the beginning of the second year, having an NPV of 0.88 M€, an IRR of 27.8% and a payback time of almost 4 years.