bluuebunny/crossref_metadata_2025 huggingface dataset:
Penyuluhan tentang Pemeliharaan Bangunan dengan Metode Anti Rayap di Kelurahan Pulau Tidung - DKI Jakarta
Authors: Rilatupa James , Septiady Yophie , Siahaan Uras
Published: June 2022

Pulau Tidung Besar dipilih sebagai lokasi kegiatan pengabdian kepada masyarakat (PKM). karena Pulau Tidung Besar merupakan salah satu pulau yang memiliki jumlah penduduk tertinggi wilayah di Kabupaten Kepulauan Seribu. Tujuan kegiatan pengabdian kepada masyarakat (PKM) ini adalah untuk memberikan penyuliuhan tentang pemeliharaan bangunan rumah tinggal mereka yang umumnya bekerja sebagai nelayan.  Pelaksanaan PKM dilakukan dengan 2 (dua) tahap (kunjungan), yaitu tahap awal dan tahap akhir. Pelaksanaannya tahap awal yang dilakukan adalah kunjungan pertama untuk mendapatkan pemetaan lokasi sasaran PKM. Sementara itu, pada tahap kunjungan kedua akan dilakukan identifikasi kerusakan dan penyuluhan kepada masyarakat. Selain itu, tim PKM dibagi menjadi 2 (dua) kelompok kegiatan. Kelompok pertama bertugas untuk melakukan kegiatan penyuluhan door-to-door dan memberikan anti rayap, agar mereka dapat merawat rumahnya dengan baik. Sementara itu, kelompok kedua bertugas untuk menyelesaikan tugas administrasi yang terkait dengan PKM, termasuk mengumpulkan data statistik yang ada di kantor kelurahan, termasuk untuk mendapatkan nomor surat MOU yang telah ditandatangani oleh lurah.

Kata Kunci: penyuluhan, identifikasi, anti rayap
SOSIALISASI DAN PELATIHAN (WORKSHOP) PEMANFAATAN LIMBAH ATAU SAMPAH DAUR ULANG SEBAGAI DEKORASI RUANG DALAM (INTERIOR) RUMAH TINGGAL DI KELURAHAN KEBON PALA KOTA ADMINISTRASI JAKARTA TIMUR TAHUN 2021
Authors: Ulinata Ulinata
Published: June 2022

Kegiatan Pengabdian kepada Masyarakat yang dijalankan Program Studi Arsitektur Fakultas Teknik UKI mengangkat tema Green Action 25 dengan judul Sosialisasi dan Pelatihan (Workshop) Pemanfaatan Limbah atau Sampah Daur Ulang Sebagai Dekorasi Ruang Dalam (Interior) Rumah Tinggal di Kelurahan Kebon Pala Kota Administrasi Jakarta Timur Tahun 2021. Kegiatan ini merupakan lanjutan dari Kegiatan Pengabdian kepada Masyarakat sebelumnya yang bertujuan untuk mengedukasi masyakat mengenai limbah atau sampah daur ulang apa saja yang dapat dimanfaatkan sebagai dekorasi ruang dalam (interior) rumah tinggal. Metodenya adalah dengan mengadakan sosialisasi dan Pelatihan (Workshop) serta mengundang narasumber yang pakar di bidang pemanfaatan limbah atau sampah daur ulang sehingga para peserta memperoleh edukasi mengenai bagaimana cara memanfaatkan limbah atau sampah daur ulang agar bisa menjadi sebuah produk dekorasi ruang dalam (interior) rumah tinggal kemudian peserta dapat secara mandiri melakukannya di rumah tinggalnya serta menularkannya kepada tetangga di lingkungan sekitar, kerabat dan keluarganya yang belum pernah ikut serta dalam sosialisasi dan pelatihan (workshop) tersebut. Prosesnya yaitu peserta mempraktikkan langsung dengan membuat hiasan dinding dari tripleks dan bungkus kopi, deterjen dan lainnya dengan menggunakan pola yang memiliki nilai estetika. Pada pelatihan (workshop) ini juga diadakan sesi tanya jawab kepada para peserta. Hasilnya menunjukkan bahwa setiap perwakilan RW di Kelurahan Kebon Pala tersebut mengikuti Pelatihan (Workshop) secara keseluruhan sehingga materi yang disampaikan dapat dipahami dan berhasil menyelesaikan hiasan dinding dari deterjen dan bungkus kopi atau sampah lainnya dengan baik dan memiliki nilai estetika.
The UMKM Terhubung Platform Teknologi Digitalisasi Dapat Bertahan Terhadap Dampak Pandemic Covid-19 di Kecamatan Kramat Jati, Jakarta Timur
Authors: Sihite Edward Baringin Oloan
Published: June 2022

Kegiatan PKM telah dilakukan tentang UMKM terhubung platform teknologi digitalisasi dapat bertahan terhadap dampak pandemic covid-19 di kecamatan Kramat Jati, Jakarta Timur. Tujuan PKM ini dilakukan untuk menarasikan UMKM yang tumbuh terhubung ke platform digitalisasi. Ide kejadian tersebut membangkitkan UMKM memanfaatkan platform teknologi digitalisasi jadi solusi ditengah pandemic covid-19 pada kecamatan Kramat Jati, Jakarta Timur. Metoda pelaksanaan PKM dilakukan berlokasi di daerah kecamatan Keramat Jati tempat pelaku UMKM berdagang. Peserta pelaku UMKM yang terpilih dibina untuk digitalisasi usaha seperti pembangunan aplikasi teknologi digitalisasi dan pembayaran transaksi digitalisasi. Instrumen yang digunakan adalah aplikasi website, pembayaran digitalisasi, dan aplikasi social media. Hasilnya dilakukan upaya dalam meningkatkan trafik pelanggan UMKM melalui promosi online di sosial media (FB dan IG) atau melalui Google dan platform pemasaran e-commerce. Upaya promosi telah dilakukan untuk menjaring calon pelanggan dan mengenalkan usaha UMKM tersebut kepada masyarakat luas secara online. Kesimpulan terbukti UMKM yang tumbuh terhubung ke platform digitalisasi ternyata tidak semua pelaku usaha mikro kecil dan menengah (UMKM) terkena dampak pandemic covid-19. UMKM yang berbisnis dengan memanfaatkan platform teknologi digitalisasi justru tumbuh signifikan.
PELATIHAN BAHASA MANDARIN DASAR DI SMP 163 JAKARTA
Authors: Elyana Elyana
Published: June 2022

Kegiatan Pengabdian Kepada Masyarakat ini bertempat di di sekolah SMP 163 yang beralamat di  Jl. Empang Tiga, RT.8/RW.2, Pejaten Timur,  Kec. Ps. Minggu, Kota Jakarta Selatan, Daerah Khusus Ibukota Jakarta 12510. Kegiatan ini dilaksanakan secara daring dengan menggunakan aplikasi Zoom dilakukan selama empat kali pertemuan dimulai tanggal pada 13 November sampai dengan 4 Desember 2021. Pelatihan ini berfokus pada pengenalan bahasa Mandarin dasar,yang bertujuan memperkenalkan bahasa Mandarin ke masyarakat luas, serta bertujuan memberikan pengetahuan  kepada peserta pelatihan tentang dasar bahasa Mandarin. Metode kegiatan ini yang dipergunakan adalah berbasis pada teori dan juga praktek dengan tahapan seperti penelitian tindakan kelas menggunakan 4 tahapan yaitu perencanaan, pelaksanaan, refleksi dan pelaporan . Hasil yang didapat dari kegiatan ini adalah para peserta didik dapat menganal bahasa Mandarin dasar, memahani kosakata dan percakaoan sederhana bahasa Mandarin, seperti memperkenalkan diri dengan menggunakan bahasa Mandarin. Dalam kegitan ini peserta sangat antusisas dan hasil yang didapat peserta mampu mengetahui apa itu vokal, konsonan dalam bahasa Mandarin, pengertian hanyu pinyin, mengenal kalimat dan sapaan sederhana dalam bahasa Mandarin serta memperkenalkan diri kedalam bahahasa Mandarin dengan lafal yang baik dan benar.
MERINTIS PELAYANAN KELOMPOK KECIL CARE CELL DAN GEREJA CABANG GEREJA BETHEL INDONESIA PASIR KOJA DI CIMAHI
Authors: Simanjuntak Ferry , Deo Jeremy , Patria Christi Joseph , Aristo Jonathan , Mulyadi Jeremy
Published: June 2022

Abstrak

Perkembangan kota Cimahi dalam bidang pendidikan, perdagangan dan industry memungkinkan terjadinya arus urbanisasi ke kota Cimahi dari berbagai daerah di Indonesia, termasuk dari kepulauan Nias dan provinsi Sumatera Utara yang berlatar belakang agama Kristen. Hal ini memungkinkan terbentuknya pelayanan pembinaan iman dalam kelompok kecil yang diberi nama Care Cell sekaligus merintis gereja cabang Gereja Bethel Indonesia Pasir Koja (GBI Pasko) Bandung sebagai tempat digembalakan. Mengingat Sekolah Tinggi Teologi Kharisma memiliki tujuan untuk mempersiapkan mahasiswa bagi tugas perintisan gereja, penggembalaan (Kependetaan) maka GBI Pasko dan STT Kharisma Bandung bekerja sama dalam merintis pelayanan care cell di Cimahi. Gereja merupakan organisme yang hidup dan didiami oleh Roh Kudus, sama seperti semua organisme yang lain yang selalu bertumbuh dan berkembang biak, demikianlah gereja sebagai organisema yang hidup terus bertumbuh baik dalam segi kualitas maupun kuantitasnya. Salah satu cara jemaat-jemaat dimuridkan adalah dengan menempatkan dan melayani mereka dalam pemuridan kelompok kecil dan dalam konteks GBI Pasko, pemuridan kelompok kecil ini diberi nama Care Cell.

Kata Kunci: Perintisan, pemuridan, gereja
Perintisan Pelayanan Kelompok Sel di Gereja Bandung City Blessing Petra
Authors: Hana Yolanda  , Ferry Simanjuntak  , Ana Ariesanita  , Hana Venturini  , Ernavina Pelmelay
Published: June 2022

Abstrak

Perintisan gereja tidak dapat dipisahkan dari misi, karena sebuah gereja dikatakan berkembang dan bertumbuh apabila gereja tersebut melakukan misi. Kegiatan gereja yang terhambat oleh karena pandemi yang terjadi tidak menghambat semangat gereja Tuhan sebagai "yang dipanggil keluar" untuk melakukan persekutuan orang-orang percaya. Dalam kesempatam ini komsel dibentuk dengan sasaran anak-anak muda usia sekolah yang diperlengkapi untuk menjangkau lingkungannya. Melalui zoom meeting diadakan beberapa kegiatan yang bertujuan untuk meningkatkan pemahaman peserta komsel akan firman Tuhan, pertumbuhan dan pendewasaan anggota juga merupakan sasaran daripada perintisan komsel ini.

Kata Kunci: perintisan gereja, komunitas sel, misi
EFEKTIVITAS PENGGUNAAN BAHASA ISYARAT DALAM PELAYANAN PELANGGAN DI COFFE SHOP OLEH KARYAWAN DENGAN PENYANDANG DISABILITAS TUNARUNGU
Authors: Stephanie Rosalind  , Siahaan Chontina
Published: June 2022

Coffee shops today are very easy to find in many places. Even small towns we can find cafes or coffee shops. But deaf coffee shop coffee shop has a different concept from most other coffee shops. This coffee shop has the uniqueness of its service that uses sign language as a way of their interaction. All employees who work in this coffee shop are deaf or disabled. The shortcomings they have are precisely what they use as the potential of the business they are currently running. That's why the author became interested in doing research on this coffee shop. The purpose of this study was to show how the communication process between hearing friends and deaf friends and their effectiveness in interacting with each other in the buying and selling process. In addition, this research also aims to find out what marketing strategies and goals this coffee shop wants to achieve. The research methods used in this study are literature studies, interviews, and data collection by conducting surveys about deaf coffee shops.
Influence of the Digestive Tract on Enzyme Activity
Authors: Ksenofontov D. A. , Ksenofontova A. A.
Published: June 2022

Enzyme activity at the digestive tract level was experimentally studied on rabbits and mini-pigs. The enzyme activity in the blood flow supplied to and from the rabbit stomach and intestines was assessed. In rabbits, the arteriovenous oxygen difference revealed a decrease in the lactate dehydrogenase and amylase activity under an increase in the alkaline phosphatase activity. A regular dependence in the dynamics of gamma-glutamyl transferase activity in the intestinal mucosa and chyme fractions was established. It was found that gamma-glutamyl transferase activity decreases in the distal direction in the mucosa of the small intestine wall. Its maximum activity was determined in the soluble fraction of the small intestine chyme, with a characteristic decrease in the distal direction. Due to the hydration of the cavitary mucus glycoproteins in the chyme and the existence of the latter in the form of an enteroplasm, the enzyme is assumed to localize in the enteric medium between the soluble and dense endogenous fraction with the purpose of displaying the maximum transport activity. A conclusion was made about the plasma-forming role of the digestive tract in terms of blood enzyme activity.
Method for Obtaining and Studying a Gel Agar-Based Medium to Preserve the Electrical Activity of Rat Brain Slices after their Long–Term Cryopreservation
Authors: Mokrushin A. A.
Published: June 2022

Cryopreservation biotechnology allows a long-term preservation makes it possible to preserve and subsequent recovery of biological objects for a long time. It This technology is used for creating is necessary to create a cryobanks. In this work, wWe have developeded a two-component freezing solution consisting of an artificial cerebrospinal fluid and agar in different concentrations. The effectiveness of the solution in terms offor long-term cryopreservation was investigated on surviving slices of the olfactory cortex of the brain of such non-hibernating animals – as rats. Changes Variations in the activities of AMPA and NMDA glutamatergic mechanisms in brain slices were studied as functional indicators of successful cryopreservation. The following agar Different concentrations of agar were used: 33%, 44% and 50%. At a concentration of 33% agar, AMPA hyperactivation and recovery of NMDA recovery mechanisms were observed. At a concentration of 44% agar, hyperactivation of both mechanisms occurred. A cComplete recovery of the activities of the AMPA and NMDA mechanisms after prolonged cryopreservation (–10°C, 52 days) was achieved at an agar concentration of 50%. The developed freezing agar-based freezing solution developed and studied by us does not contains no “heavy” protectors (DMSO), antibiotics, and cations, such as Ba2+ and Sr2+, which normally lead to an irreversible blockade of AMPA and NMDA mechanisms. Thus, an the agar-based freezingdeveloped solution solution helpscontributes to maintaining a high level of activity of AMPA and NMDA activity mechanisms in slices during their cryopreservation. The developed solution can be used to create a cryobank of nervous tissue.
Quercetin-Coating Promotes Osteogenic Differentiation, Osseointegration and Anti-Inflammatory Properties of Nano-Topographic Modificated 3D-Printed Ti6Al4V Implant
Authors: Liu Nian , Wang Hui , Fu Zeyu , Zhang Chuxi , Hui Wenyu , Wu Jinyang , Zhang Yong , Zhang Shilei
Published: June 2022

The capabilities of osseointegration and anti-inflammatory properties are of equal significance to the bio-inert titanium implant surface. Quercetin has proved its capacities of activating anti-inflammation through macrophage modulation and promoting osteogenic differentiation. Herein, we fabricated quercetin-coating on nano-topographic modificated 3D-printed Ti6Al4V implant surface. Subsequently the biological cells responses in vitro, anti-inflammatory and osseointegration performance in vivo were evaluated. In vitro studies indicated that quercetin-coating can enhance the adhesion and osteogenic differentiation of rBMSCs, while modulating the polarization of macrophages from M1 to M2 phase and improving the anti-inflammatory and vascular gene expression. Moreover, quercetin-loaded implants reduced the level of peri-implant inflammation and ameliorated new bone formation and rapid osseoinegration in vivo. Quercetin-coating might provide a feasible and favorable scheme for endowing 3D-printed titanium alloy implant surface with enhanced the rapid osseointegration and anti-inflammatory properties.
Carbon-Based Modification Materials for Lithium-ion Battery Cathodes: Advances and Perspectives
Authors: Zhou Luozeng , Yang Hu , Han Tingting , Song Yuanzhe , Yang Guiting , Li Linsen
Published: June 2022

Lithium-ion batteries (LIBs) have attracted great attention as an advanced power source and energy-storage device for years due to their high energy densities. With rapid growing demands for large reversible capacity, high safety, and long-period stability of LIBs, more explorations have been focused on the development of high-performance cathode materials in recent decades. Carbon-based materials are one of the most promising cathode modification materials for LIBs due to their high electrical conductivity, large surface area, and structural mechanical stability. This feature review systematically outlines the significant advances of carbon-based materials for LIBs. The commonly used synthetic methods and recent research advances of cathode materials with carbon coatings are first represented. Then, the recent achievements and challenges of carbon-based materials in LiCoO2, LiNixCoyAl1-x-yO2, and LiFePO4 cathode materials are summarized. In addition, the influence of different carbon-based nanostructures, including CNT-based networks and graphene-based architectures, on the performance of cathode materials is also discussed. Finally, we summarize the challenges and perspectives of carbon-based materials on the cathode material design for LIBs.
Digital Therapeutics in Perspective: From Regulatory Challenges to Post-Marketing Surveillance
Authors: Crisafulli Salvatore , Santoro Eugenio , Recchia Giuseppe , Trifirò Gianluca
Published: June 2022

Digital therapeutics (DTx) are innovative therapeutic interventions, in which the therapeutic activity is carried out by algorithms and software. They represent a new opportunity especially for the treatment of chronic pathologies associated with dysfunctional lifestyles and behaviors, where conventional drug therapy is not fully effective. DTx are highly customizable therapeutic tools, allowing a better involvement of the patient in the management of the disease. To date, the clinical use of DTx in Europe is still generally limited. One of the main issues related to DTx is the general lack of education of healthcare professionals in this sector that leads to a knowledge gap between data scientists, and physicians, who should identify all those clinical needs that could be better addressed through the use of DTx. From a regulatory perspective, DTx are classified as Medical Devices. However, their research and development process is similar to that of conventional drugs, since they are tested in clinical trials and their approval refers to specific therapeutic indications. For this reason, precise criteria for marketing approval, for the health technology assessment and for the reimbursement of these therapies need to be defined. Moreover, as for conventional drugs, it is also fundamental to conduct post-marketing studies on DTx, aiming at re-evaluating the benefit-risk profile and collecting information related to large-scale use in real world setting. The aim of this review is to describe the main challenges for DTx development, regulation and widespread clinical use.
A New Conulariid (Cnidaria, Scyphozoa) From the Terminal Ediacaran of Brazil
Authors: Leme Juliana M. , Van Iten Heyo , Simões Marcello G.
Published: June 2022

Paraconularia ediacaran. sp., the oldest documented conulariid cnidarian, is described based on a compressed thin specimen from the terminal Ediacaran Tamengo Formation near Corumbá, Mato Grosso do Sul State, Brazil. The conulariid was collected from a laminated silty shale bed also containingCorumbella werneriand vendotaenid algae. The specimen consists of four partial faces, two of which are mostly covered, and one exposed corner sulcus. The two exposed faces exhibit 32 bell-curve-shaped, nodose transverse ribs, with some nodes preserving a short, adaperturally directed interspace ridge (spine). The transverse ribs bend adapertureward on the shoulders of the corner sulcus, within which the ribs terminate, with the end portions of the ribs from one face alternating with and slightly overlapping those from the adjoining face. This is the first Ediacaran body fossil showing compelling evidence of homology with a particular conulariid genus. However, unlike the periderm of Phanerozoic conulariids, the periderm ofP.ediacaralacks calcium phosphate, a difference which may be original or an artifact of diagenesis or weathering. The discovery ofP.ediacarain the Tamengo Formation corroborates the hypothesis, based in part on molecular clock studies, that cnidarians originated during mid-late Proterozoic times, and serves as a new internal calibration point, dating the split between scyphozoan and cubozoan cnidarians at no later than 542 Ma. Furthermore,P. ediacarareinforces the argument that the final phase of Ediacaran biotic evolution featured the advent of large-bodied eumetazoans, including, possibly, predators.
Identifying and Mapping Alteration Minerals Using HySpex Airborne Hyperspectral Data and Random Forest Algorithm
Authors: Wang Shanshan , Zhou Kefa , Wang Jinlin , Zhao Jie
Published: June 2022

Airborne hyperspectral remote sensing data provide rapid, non-destructive, and near laboratory quality reflectance spectra for mineral mapping and lithological discrimination, thereby ushering an innovative era of remote sensing. In this study, NEO HySpex cameras, which comprise 504 spectral channels in the spectral ranges of 0.4–1.0 μm and 1.0–2.5 μm, were mounted on a delta wing XT-912 aircraft. The designed flexibility and modular nature of the HySpex aircraft hyperspectral imaging system made it relatively easy to test, transport, install, and remove the system multiple times before the acquisition flights. According to the design fight plan, including the route distance, length, height, and flight speed, we acquired high spectral and spatial resolutions airborne hyperspectral images of Yudai porphyry Cu (Au, Mo) mineralization in Kalatag District, Eastern Tianshan terrane, Northwest China. By comparing the features of the HySpex hyperspectral data and standard spectra data from the United States Geological Survey database, endmember pixels of spectral signatures for most alteration mineral assemblages (goethite, hematite, jarosite, kaolinite, calcite, epidote, and chlorite) were extracted. After a HySpex data processing workflow, the distribution of alteration mineral assemblages (iron oxide/hydroxide, clay, and propylitic alterations) was mapped using the random forest (RF) algorithm. The experiments demonstrated that the workflow for processing data and RF algorithm is feasible and active, and show a good performance in classification accuracy. The overall classification accuracy and Kappa classification of alteration mineral identification were 73.08 and 65.73%, respectively. The main alteration mineral assemblages were primarily distributed around pits and grooves, consistent with field-measured data. Our results confirm that HySpex airborne hyperspectral data have potential application in basic geology survey and mineral exploration, which provide a viable alternative for mineral mapping and identifying lithological units at a high spatial resolution for large areas and inaccessible terrains.
Gas Bubble Dynamics During Methane Hydrate Formation and its Influence on Geophysical Properties of Sediment Using High-Resolution Synchrotron Imaging and Rock Physics Modeling
Authors: Madhusudhan B. N. , Sahoo S. K. , Alvarez-Borges F. , Ahmed S. , North L. J. , Best A. I.
Published: June 2022

Gas bubble in aquatic sediments has a significant effect on its geophysical and geomechanical properties. Recent studies have shown that methane gas and hydrate can coexist in gas hydrate–bearing sediments. Accurate calibration and understanding of the fundamental processes regarding such coexisting gas bubble dynamics is essential for geophysical characterization and hazard mitigation. We conducted high-resolution synchrotron imaging of methane hydrate formation from methane gas in water-saturated sand. While previous hydrate synchrotron imaging has focused on hydrate evolution, here we focus on the gas bubble dynamics. We used a novel semantic segmentation technique based on convolutional neural networks to observe bubble dynamics before and during hydrate formation. Our results show that bubbles change shape and size even before hydrate formation. Hydrate forms on the outer surface of the bubbles, leading to reduction in bubble size, connectivity of bubbles, and the development of nano-to micro-sized bubbles. Interestingly, methane gas bubble size does not monotonously decrease with hydrate formation; rather, we observe some bubbles being completely used up during hydrate formation, while bubbles originate from hydrates in other parts. This indicates the dynamic nature of gas and hydrate formation. We also used an effective medium model including gas bubble resonance effects to study how these bubble sizes affect the geophysical properties. Gas bubble resonance modeling for field or experimental data generally considers an average or equivalent bubble size. We use synchrotron imaging data to extract individual gas bubble volumes and equivalent spherical radii from the segmented images and implement this into the rock physics model. Our modeling results show that using actual bubble size distribution has a different effect on the geophysical properties compared to the using mean and median bubble size distributions. Our imaging and modeling studies show that the existence of these small gas bubbles of a specific size range, compared to a bigger bubble of equivalent volume, may give rise to significant uncertainties in the geophysical inversion of gas quantification.
Reproducible and Repeatable Generation of 4-He, γ-rays, and Heat in Light and Heavy Waters at Room Temperature
Authors: Torabi-Monfared Hossein , Doroodmand Mohammad Mahdi
Published: June 2022

The extraordinary claim of observing nuclear fusion products and excess heat during heavy water electrolysis at room temperature was sensationalized in 1989. Unfortunately, it was rejected quickly by scientific communities. At the last attempt to access the accuracy of the previous works in this field, a Google-funded team tried to examine all reported works with their corresponding conditions to confirm the claimed results. Finally, they found that there was no reasonable proof of nuclear fusion reactions under the reported conditions. Here, we introduced a method to apply a unique triggering potential waveform to a simple two micro-shaft system in both heavy and light concentrated salinity waters which resulted in detecting 4-helium, gamma rays, and heat repeatedly and reproducibly. In this work, two types of nuclear fusion reactions were observed: 1) A D + D fusion reaction in potassium halide salt solutions in heavy water and 2) a new type of fusion reaction in carbon-containing salt solutions in both light and heavy waters. In the latter type, it was proved that the existence of carbon atoms in an anion structure is critical to observe the 4-helium, gamma rays, and heat.
A Comparison of Direct and Indirect Flexibilities on the Self-Consumption of an Office Building: The Case of Predis-MHI, a Smart Office Building
Authors: Twum-Duah Nana Kofi , Amayri Manar , Ploix Stéphane , Wurtz Frédéric
Published: June 2022

The purpose of this paper is to provide a method for assessing the impact of direct and indirect flexibilities on the self-consumption of office buildings. The goal is to assess how both the human actors and technical interventions can affect or mitigate deviations in the self-consumption level of a building from its optimal. This paper considers the Predis-MHi platform (a living lab) as a representative case study and applies a Mixed Integer Linear Programming optimization to manage both the direct (stationary battery charging) and indirect flexibilities (Electric Vehicle charging when users plug and unplug their vehicles). Our results indicate that the potential for a building’s self-consumption improvement using indirect flexibilities does exist and can be quantified. However, this type of flexibility is highly dependent on human actors which presents a high level of uncertainty and is difficult to account for in all stages of a building’s development and use. Direct flexibilities such as stationary battery storage can be used to mitigate the undesired effects of having significant levels of indirect flexibilities on a tertiary sector building’s energy performance. The results from this study could potentially be modeled into an indicator, which would serve to influence occupant behavior towards a desired optimal.
Transportability Improvement of a Gas–Liquid Rotodynamic Pump Using the Two-Step Multi-Objective Optimization Strategy
Authors: Zhang Wenwu , Zhu Baoshan , Zi Dan , Ma Zhe , Wang Fujun
Published: June 2022

The development of multiphase pumps is restricted because of low efficiency and poor mixing transportation capacity. In this study, a two-step multi-objective optimization design system for a multiphase pump is constructed using a three-dimensional (3D) design theory and multi-objective optimization techniques. The transportability improvement for the pump impeller is achieved by implementing the optimization variables of its geometry and blade loading and the optimization objectives containing the pump efficiency and gas uniformity. The optimal results of impeller geometry show that the blade wrap angle and control parameters of the hub have remarkable effects on the pump efficiency and gas uniformity. The optimal results of impeller blade loading show that the pump efficiency is improved if the impeller with large loading at the leading edge, large slope at the middle part, and large negative high-pressure edge angle. The gas uniformity is improved if the hub loading at the middle and trailing parts is larger than the shroud loading. Compared to the original test impeller, the pump efficiency with the impeller T-Opt1 and the gas uniformity at the impeller outlet are improved by 10.81% and 6.91%, respectively. The maximum fluctuation amplitudes in T-Opt1 and its corresponding guide vane are reduced by 0.61% and 67.76%, respectively.
Vulnerability Assessment and Spatio-Temporal Dynamics Analysis of Agricultural Flood in China
Authors: Liu Yinong , Zheng Jiaxi , Lu Honggang , Li Xijian
Published: June 2022

Flood is one of the main problems faced by agricultural production in China. The research of agriculture’s floods vulnerability is the premise of scientifically dealing with floods. Based on the vulnerability assessment framework of “sensitivity-exposure-adaptability,” this paper selects 14 evaluation indicators from three aspects: sensitivity, exposure, adaptability, and the index weights which are determined by the entropy weight method to evaluate the sensitivity, resilience, and vulnerability of flood In terms of time, China’s overall flood vulnerability shows a trend of increasing first and then decreasing. From a spatial point of view, the number of highly vulnerable areas is relatively small which are mainly concentrated in Henan, Hubei, Anhui and other provinces, and most areas of the country are at low and mild levels. From the factor analysis model, the main contributing factors of agricultural flood exposure, sensitivity and adaptability are soil erosion control area, forest coverage rate, total reservoir capacity and total power of agricultural machinery. Therefore, controlling soil erosion, increasing forest coverage, further improving water conservancy facilities and strengthening agricultural mechanization level are the keys to reduce vulnerability of agricultural floods.
Comparative Analysis of the Mitochondrial Genome of Galatheanthemum sp. MT-2020 (Actiniaria Galatheanthemidae) From a Depth of 9,462 m at the Mariana Trench
Authors: Shi Mengke , Qi Li , He Li-Sheng
Published: June 2022

The hadal zone, which represents the deepest marine habitat on Earth (6,000–11,000 m), is a harsh environment mainly characterized by extremely high hydrostatic pressure, and this habitat is believed to have a high degree of endemism. The deep-sea anemone family Galatheanthemidae comprises two valid species exclusively from the hadal; however, no other information about this family is currently available. In the present study, a sea anemone was collected from a depth of 9,462 m at the Mariana Trench and was defined as Galatheanthemum sp. MT-2020 (Actiniaria Galatheanthemidae). The mitochondrial genome of Galatheanthemum sp. MT-2020 was circular, was 16,633 bp in length, and contained two ribosomal RNA genes, 13 protein-coding genes and two transfer RNA genes. The order of the genes of Galatheanthemum sp. MT-2020 was identical to that of the majority of the species of the order Actiniaria. The value of the AT-skew was the lowest in the whole mitochondrial genome, with a positive GC skew value for the atp8 gene, while other species, except Antholoba achates, had the negative values of the GC skew. Galatheanthemum sp. MT-2020 was clustered with another abyssal species, Paraphelliactis xishaensis, in the phylogenetic tree, and these species diverged in the early Jurassic approximately 200 Mya from the shallow-sea species. The usage ratio of valine, which is one of the five amino acids with the strongest barophilic properties, in the mitochondrial genomes of the two abyssal species was significantly higher than that in other species with habitats above the depth of 3,000 m. The ω (dN/dS) ratio of the genomes was 2.45-fold higher than that of the shallow-sea species, indicating a slower evolutionary rate. Overall, the present study is the first to provide a complete mitogenome of sea anemones from the hadal and reveal some characteristics that may be associated with adaptation to an extreme environment.
The Crosstalk Between Immune Infiltration, Circulating Tumor Cells, and Metastasis in Pancreatic Cancer: Identification of HMGB3 From a Multiple Omics Analysis
Authors: Tang Hao-dong , Wang Yang , Xie Peng , Tan Si-yuan , Li Hai-feng , Shen Hao , Zhang Zheng , Lei Zheng-qing , Zhou Jia-hua
Published: June 2022

Metastasis is the major cause of death in patients with pancreatic ductal adenocarcinoma (PDAC), and circulating tumor cells (CTCs) play an important role in the development of metastasis. However, few studies have uncovered the metastasis mechanism of PDAC based on CTCs. In this study, the existing bulk RNA-sequencing (bulk RNA-seq) and single-cell sequencing (scRNA-seq) data for CTCs in pancreatic cancer were obtained from the Gene Expression Omnibus (GEO) database. Analysis of tumor-infiltrating immune cells (TIICs) by CIBERSORT showed that the CTCs enriched from the peripheral blood of metastatic PDAC were found to contain a high proportion of T cell regulators (Tregs) and macrophages, while the proportion of dendritic cells (DCs) was lower than that enriched from localized PDAC. Through weighted gene co-expression network analysis (WGCNA) and the result of scRNA-seq, we identified the hub module (265 genes) and 87 marker genes, respectively, which were highly associated with metastasis. The results of functional enrichment analysis indicated that the two gene sets mentioned above are mainly involved in cell adhesion and cytoskeleton and epithelial–mesenchymal transition (EMT). Finally, we found that HMGB3 was the hub gene according to the Venn diagram. The expression of HMGB3 in PDAC was significantly higher than that in normal tissues (protein and mRNA levels). HMGB3 expression was significantly positively correlated with both EMT-related molecules and CTC cluster–related markers. Furthermore, it was also found that HMGB3 mutations were favorably related to tumor-associated immune cells through the TIMER2.0 online tool. We further demonstrated that PDAC patients with higher HMGB3 expression had significantly worse overall survival (OS) in multiple datasets. In summary, our study suggests that HMGB3 is a hub gene associated with EMT in CTCs, the formation of CTC clusters, and infiltration patterns of immune cells favorable for tumor progression and metastasis to distant organs.
Digital Polarization Programmable Metasurface for Continuous Polarization Angle Rotation and Radar Applications
Authors: Wang Yidan , Shi Hongyu , Chen Juan , Yi Jianjia , Dong Liang , Zhang Anxue , Liu Haiwen
Published: June 2022

Polarization angle manipulation has been a vital technic in radar applications. This paper proposes and demonstrates a digital polarization programmable metasurface for continuous polarization angle rotation and radar applications. By coding “0” and “1” elements with the two orthogonally polarized waves having 180° phase difference, the polarization angle of electromagnetic (EM) waves can be continually and arbitrarily manipulated. The designed metasurface adopts a patch-transmission and line-patch structure and integrates two polarization channels to carry out 1-bit coding. By rotating the azimuth angle of the designed metasurface mechanically, a continuous rotation of the polarization angle of the transmitted wave can be achieved. Moreover, the transmission around 9.4 GHz can reach higher than 95%. The metasurface sample with optimized structure parameters has been fabricated and tested, where the measurement agrees well with the simulation results. In addition, a radar detection experiment was implemented with an anisotropic target, demonstrating the practical use of the proposed metasurface for polarimetric radar.
A Review of the Advancements in the in-vitro Modelling of Acute Ischemic Stroke and Its Treatment
Authors: Johnson Sarah , Dwivedi Anushree , Mirza Mahmood , McCarthy Ray , Gilvarry Michael
Published: June 2022

In-vitro neurovascular models of large vessel occlusions (LVOs) causing acute ischemic stroke (AIS) are used extensively for pre-clinical testing of new treatment devices. They enable physicians and engineers to examine device performance and the response of the occlusion to further advance design solutions for current unmet clinical needs. These models also enable physicians to train on basic skills, to try out new devices and new procedural approaches, and for the stroke team to practice workflows together in the comfort of a controlled environment in a non-clinical setting. Removal of the occlusive clot in its entirety is the primary goal of the endovascular treatment of LVOs via mechanical thrombectomy (MT) and the medical treatment via thrombolysis. In MT, recanalization after just one pass is associated with better clinical outcomes than procedures that take multiple passes to achieve the same level of recanalization, commonly known as first pass effect (FPE). To achieve this, physicians and engineers are continually investigating new devices and treatment approaches. To distinguish between treatment devices in the pre-clinical setting, test models must also be optimized and expanded become more nuanced and to represent challenging patient cohorts that could be improved through new technology or better techniques. The aim of this paper is to provide a perspective review of the recent advancements in the in-vitro modeling of stroke and to outline how these models need to advance further in future. This review provides an overview of the various in-vitro models used for the modeling of AIS and compares the advantages and limitations of each. In-vitro models remain an extremely useful tool in the evaluation and design of treatment devices, and great strides have been made to improve replication of physiological conditions. However, further advancement is still required to represent the expanding indications for thrombectomy and thrombolysis, and the generation of new thrombectomy devices, to ensure that smaller treatment effects are captured.
In Search for the Retrievable Memory Trace in an Insect Brain
Authors: Menzel Randolf
Published: June 2022

The search strategy for the memory trace and its semantics is exemplified for the case of olfactory learning in the honeybee brain. The logic of associative learning is used to guide the experimental approach into the brain by identifying the anatomical and functional convergence sites of the conditioned stimulus and unconditioned stimulus pathways. Two of the several convergence sites are examined in detail, the antennal lobe as the first-order sensory coding area, and the input region of the mushroom body as a higher order integration center. The memory trace is identified as the pattern of associative changes on the level of synapses. The synapses are recruited, drop out, and change the transmission properties for both specifically associated stimulus and the non-associated stimulus. Several rules extracted from behavioral studies are found to be mirrored in the patterns of synaptic change. The strengths and the weaknesses of the honeybee as a model for the search for the memory trace are addressed in a comparison with Drosophila. The question is discussed whether the memory trace exists as a hidden pattern of change if it is not retrieved and whether an external reading of the content of the memory trace may ever be possible. Doubts are raised on the basis that the retrieval circuits are part of the memory trace. The concept of a memory trace existing beyond retrieval is defended by referring to two well-documented processes also in the honeybee, memory consolidation during sleep, and transfer of memory across brain areas.
Molecular Characterization of a First-in-Human Clinical Response to Nimesulide in Acute Myeloid Leukemia
Authors: Tomaz Victória , Griesi-Oliveira Karina , Puga Renato D. , Conti Bruno J. , Santos Fabio P. S. , Hamerschlak Nelson , Campregher Paulo V.
Published: June 2022

Acute myeloid leukemia (AML) is a hematologic malignancy associated with high morbidity and mortality. Here we describe a case of a patient with AML who presented a partial response after utilization of the non-steroidal anti-inflammatory drug nimesulide. The response was characterized by complete clearance of peripheral blood blasts and an 82% decrease of bone marrow blasts associated with myeloblast differentiation. We have then shown that nimesulide induces in vitro cell death and cell cycle arrest in all AML cell lines (HL-60, THP-1, OCI-AML2, and OCI-AML3). Weighted Correlation Network Analysis (WGCNA) of serial whole-transcriptome data of cell lines treated with nimesulide revealed that the sets of genes upregulated after treatment with nimesulide were enriched for genes associated with autophagy and apoptosis, and on the other hand, the sets of downregulated genes were associated with cell cycle and RNA splicing. Serial transcriptome of bone marrow patient sample confirmed the upregulation of genes associated with autophagy after the response to nimesulide. Lastly, we demonstrated that nimesulide potentiates the cytotoxic in vitro effect of several Food and Drug Administration (FDA)-approved chemotherapy drugs used in AML, including cytarabine.
Racial Disparities in Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy: Does Aggressive Surgical Treatment Overcome Cancer Health Inequities?
Authors: Freudenberger Devon C. , Deng Xiaoyan , Vudatha Vignesh , Riner Andrea N. , Herremans Kelly M. , Bandyopadhyay Dipankar , Fernandez Leopoldo J. , Trevino Jose G.
Published: June 2022

Background

Advanced cancer states perpetuate health-related disparities. Peritoneal-based cancers are clinically advanced cancers that present a significant clinical dilemma. Peritoneal cancers are managed aggressively with cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC). While racial and ethnic disparities are prevalent in cancer, there are no studies investigating if racial disparities exist in patients with peritoneal carcinomatosis managed with CRS and HIPEC. We hypothesized that this advanced disease state further delineates racial disparities.

Methods

A retrospective chart review was conducted on patients with peritoneal carcinomatosis receiving CRS and HIPEC at a single institution from January 1, 2017-October 4, 2021. Descriptive statistics were used to compare racial groups. The Cox Proportional Hazards Model and Log Rank Test were used for multivariate and overall survival analysis.

Results

In total, 67 patients underwent CRS and HIPEC, of which 41 (61.2%) were White, 20 (29.8%) were Black, 3 (4.5%) were Asian, and 3 (4.5%) were Other race. When compared to White patients, Black patients had lower income (p=0.0011), higher incidence of hypertension (p=0.0231), and lower performance status (p=0.0441). Cancer type, including colorectal, appendiceal, ovarian, etc., was similar between groups (p=0.8703). Despite these differences in sociodemographic and morbidity factors, when comparing Black patients to White patients, there were no differences in peritoneal cancer index score (13.2 vs. 12.3, p=0.6932), estimated blood loss (748 vs. 655 mL, p=0.6332), minor/major complication rates (1.1 vs. 1.2, p=0.7281; 0.4 vs. 0.7, p=0.3470, respectively), 30-day readmission rates (25.0% vs. 17.1%, p=0.6210), disease recurrence (40.0% vs. 51.2%, p=0.3667), or 30-day mortality (0.0% vs. 2.4%, p=1.0000). Overall survival was similar for Black and White patients (p=0.2693). The occurrence of a major complication was the only factor associated with overall survival (HR 2.188 [1.502, 3.188], p< 0.0001).

Conclusions

Despite differences in patient socioeconomic factors and comorbid conditions, outcomes were similar between Black and White patients receiving CRS and HIPEC at our institution. While larger studies with more diverse patient populations are needed to confirm these findings, our data provide evidence that aggressive surgical management across diverse patient populations allows for equitable outcomes.
Radiotherapy in Oligometastatic, Oligorecurrent and Oligoprogressive Prostate Cancer: A Mini-Review
Authors: Yaney Alexander , Stevens Andrew , Monk Paul , Martin Douglas , Diaz Dayssy A. , Wang Shang-Jui
Published: June 2022

Globally, prostate cancer is one of the most common malignancies affecting men. With the advent of advanced molecular imaging, an increasing number of men are found to have oligometastatic disease (OD) either at primary diagnosis or at the time of biochemical failure. No strict definition exists for OD, with historical and ongoing studies utilizing diverse criteria. There is mounting evidence from many different malignancies that patients with OD have improved outcomes compared to their widely metastatic counterparts. As such, treatment intensification of those with OD or oligoprogressive disease has become an area of intense interest and study. This article will review the biology, evidence and controversy behind the treatment of de novo oligometastatic, oligorecurrent and oligoprogressive prostate cancer.
Research Progress of Traditional Chinese Medicine in Treatment of Myocardial fibrosis
Authors: Ren Chunzhen , Liu Kai , Zhao Xinke , Guo Huan , Luo Yali , Chang Juan , Gao Xiang , Lv Xinfang , Zhi Xiaodong , Wu Xue , Jiang Hugang , Chen Qilin , Li Yingdong
Published: June 2022

Effective drugs for the treatment of myocardial fibrosis (MF) are lacking. Traditional Chinese medicine (TCM) has garnered increasing attention in recent years for the prevention and treatment of myocardial fibrosis. This Article describes the pathogenesis of myocardial fibrosis from the modern medicine, along with the research progress. Reports suggest that Chinese medicine may play a role in ameliorating myocardial fibrosis through different regulatory mechanisms such as reduction of inflammatory reaction and oxidative stress, inhibition of cardiac fibroblast activation, reduction in extracellular matrix, renin-angiotensin-aldosterone system regulation, transforming growth Factor-β1 (TGF-β1) expression downregulation, TGF-β1/Smad signalling pathway regulation, and microRNA expression regulation. Therefore, traditional Chinese medicine serves as a valuable source of candidate drugs for exploration of the mechanism of occurrence and development, along with clinical prevention and treatment of MF.