bluuebunny/crossref_metadata_2025 huggingface dataset:
Finding the link from a surface adhesin to the actin motor for plasmodium merozoite invasion
Authors:   , Nie Hui , Bergman Lawrence W
Published: July 2024

Malaria parasite invasion involves the linkage between the host cell being invaded and the actin-myosin motor of the parasite that drives the invasion. In sporozoites, the hepatocyte invading stage of the parasite, this function is completed by Thrombospondin Related Anonymous Protein (TRAP), which links the host cell being invaded to the actin-myosin motor via an indirect linkage requiring parasite aldolase. However, the nature of the molecule(s) that perform(s) this function in the blood stage of the parasite is less studied. Based on previous research, Plasmodium TRAP has been characterized as a Type I transmemberane protein. Its extracellular domain contains the von Willebrand factor A (A domain) and thrombospondin type I (TSP1) domains, which are involved in the host cell binding function. TRAP has a short cytoplasmic tail, which is acidic in nature, and has a conserved tryptophan residue close to the carboxy-terminus. We have identified and characterized two additional molecules through a bioinformatic approach using the completed P. falciparum genome sequence and the sequence characteristics of TRAP. These molecules are denoted MTRAP (Merozoite TRAP-like molecule), and TLP (TRAP- Like Protein). To characterize these two molecules, we have performed aldolase binding assays, red blood cell (RBC) binding assays, gene knockout studies, and immunization/protection assays for both molecules. Also for MTRAP, we performed microarray studies and real-time PCR to compare the different gene expression mRNA patterns in the wild type (WT) and the MTRAP knockout (KO) parasites. In conclusion, we have found that both molecules bind to aldolase in vitro, but not to RBCs in vitro. Gene knockout studies have shown that both molecules were nonessential, although the invasion ability of the KO parasites was altered from that of the WT parasite. Immunization with either molecule has not generated a protective response in mice upon subsequent parasite challenge. Interestingly, for MTRAP, the microarray studies show that many invasion-related molecules were significantly upregulated in the MTRAP KO parasites.
Post-translational Modification of Brain Proteins with O-Linked N-Acetyl-D-Glucosamine
Authors:   , Skorobogatko Yuliya , Vosseller Keith
Published: July 2024

This work contributes to understanding how post-translational modifications of proteins modulate synaptic function. Modification of synaptic proteins with the regulatory intracellular carbohydrate 0-linked N-acetylglucosamine (0-G1cNAc) is the focus of this study, which resulted in mapping of the first 0-G1cNAc sites on human brain proteins and established that modification of the synaptic protein, synapsin I, with 0-G1cNAc modulates synaptic plasticity (a property of neurons to modulate the strength of communication between synapses which is indispensible for learning and memory). Previously we found that pharmacological elevation of 0-G1cNAc in mouse brain facilitates synaptic plasticity. This facilitation is in part due to a presynaptic mechanism. One of the important presynaptic mechanisms of synaptic plasticity is generation and mobilization of a so called "reserve pool" of synaptic vesicles, which is used in addition to a "readily releasable pool" to maintain neurotransmitter release during times of high neuronal activity. Synapsin I, which is extensively modified by 0-G1cNAc, is a key synaptic vesicle binding protein that regulates the size and release of the reserve pool. Disruption of synapsin I function compromises the reserve pool of synaptic vesicles, leading to epilepsy and memory deficits. We addressed the role of synapsin I 0- GIcNAcylation in synaptic plasticity using a combination of biochemical tools, molecular biology, and imaging in primary hippocampal neurons. Based on our findings we propose a model where O-GlcNAcylation of synapsin I disrupts its association with synaptic vesicles and promotes trafficking of synaptic vesicles from the reserve pool to the readily releasable pool, thus facilitating synaptic plasticity. A single 0-GleNAc site, Thr87 which is crucial for regulating synapsin I, is located within the amphipathic lipid-packing sensor (ALPS) motif, which is responsible for preferential association of synapsin I with synaptic vesicles vs. the cell membrane. Thus, Thr87 0-GIcNAcylation decreases the affinity of synapsin I to synaptic vesicles likely through the disruption of the ALPS motif function. Since we found that synapsin 0-GleNAcylation is increased during synapse maturation, we propose that the regulation of synapsin I by 0-GIcNAc is important during synaptogenesis. Meanwhile the regulation of synapsin I O-GlcNAcylation during neurotransmission remains to be investigated.
Arachidonic acid release by cPLA₂ and ceramide synthesis may be causally related to nitric oxide induced apoptosis in vascular smooth muscle cells
Authors:   , Pilane Cyril M. , Nickels Joseph T
Published: July 2024

In order to investigate the possible role of arachidonic acid in the apoptosis of smooth muscle, we induced apoptosis in cultured rat aortal smooth muscle cells by treatment with either LTV (Ultraviolet radiation, tumor necrosis factor-[alpha] (TNF-[alpha]) or nitric oxide (NO) donor drugs (sodium nitroprusside (NP), or S-nitroso-N-acetyl penicillamine, SNAP). Apoptosis was detected by either DNA fragmentation analysis of TUNEL analysis. UV radiation and NO were observed to stimulate apoptosis in the cells as well as arachidonic acid release from the cells. They also induced increased levels of cPLA₂ in the cells. These agents stimulated arachidonic acid release somewhat earlier than they stimulated apoptosis in the cells. UV radiation appeared to have a synergistic effect on NP induced cellular apoptosis and arachidonic acid release, when compared with effects of UV radiation, or NP individually. However, when NO levels were determined via Greiss reaction UV radiation was shown to stimulate NO release from either NP or SNAP, thereby greatly increasing the NO concentration in medium. The inhibition of cPLA₂ by arachidonyl trifluoromethyl ketone (AACOCF₃) also led to the inhibition of arachidonic acid release from the cells as well as inhibition of apoptosis. Furthermore, a PLA₂ specific activator peptide, PLAP, showed an increase in arachidonic acid release accompanied by an increase in apoptosis. The cPLA₂ specific inhibitor, AACOCF₃, blocked the PLAP induced effects in a concentration dependent manner. Additional evidence for the involvement of cPLA₂ in VSMC apoptosis was shown by use of the sense and the antisense oligonucleotides. The antisense oligonucleotide abolished cPLA₂ expression in the cells at the highest concentrations used. The effect was accompanied by decrease in arachidonic acid release and apoptosis as stimulated by NP. This observation was not seen with the sense oligonucleotide. These observations provide evidence that arachidonic acid may be involved in apoptosis in VSMCs. Another second messenger lipid investigated was ceramide. Ceramide has been implicated in apoptosis and appears to be involved in NO-induced apoptosis. NP increased the ceramide in smooth muscle cells in a time and NO concentration dependent manner. Addition of exogenous ceramide, in a form of C2-ceramide showed apoptosis, which was not seen with the C2-dihydroceramide analog. The NO-induced ceramide synthesis appears to be made from sphingomyelinase since an inhibitor desipramine decreases ceramide synthesis by NP treated cells. These observations indicated that ceramide is involved in NO induced apoptosis of VSMCs, perhaps as a mediator of apoptosis.
The impact of locus of control on the perceptions and interactions of mental health professionals with managed care organizations
Authors:   , Stein Lisa Merryl , Barakat Lamia
Published: July 2024

Managed care is a force that is invading every aspect of an individual's medical treatment and whose impact is felt by patients and the persons providing the services. In this study the role of managed care in the work lives of mental health professionals was investigated. The goals were to examine partial hospital employees' attitudes and opinions toward managed care involvement at their workplaces and explore the association of an employee's locus of control with his or her view of managed care organizations. Work stressors and coping techniques were also addressed. Three hundred employees from 60 partial hospital sites throughout Pennsylvania received surveys. One hundred thirteen surveys, a 33% return, were used for this research. The survey consisted of six forms which included demographics, Attitudes to Managed Care (developed by this author), Work Locus of Control Scale (Spector, 1988), Abbreviated Measure of Internal-External Locus of Control (Valecha & Ostrom, 1974), Daily Hassles Scale (Kanner, Coyne, Schaefer, & Lazarus, 1981) and the COPE (Carver, Scheier, & Weintraub, 1989). The study did not support the hypotheses that general locus of control and work locus of control would be significantly associated nor that either type of locus of control would significantly correlate with managed care attitudes. Attitudes to Managed Care did not significantly coffelate with employee demographic variables. There was also no significant association between coping techniques or work hassles with attitudes to managed care. However, a very specific measure of control, the question of whether the respondent has control over managed care, did correlate significantly with attitudes to managed care. This study also supported research regarding the tendency toward internality in mental health professionals, and that coping techniques, such as planning, are often used by Internals. Follow up research with more partial site employees is encouraged. Interestingly, the education levels, training, and work experience of the employees of partial hospitals may be quite different from other mental health settings, such as private practice, and thus these dynamics may be quite unique.
The timeless protein coordinates multiple pathways at the DNA replication fork to preserve genomic integrity
Authors:   , Leman Adam Robert , Noguchi Eishi
Published: July 2024

The DNA replication machinery is responsible for the high fidelity duplication of the human genome, containing over three billion nucleotides. Dysfunction of the replication processes lead to spontaneous, heritable genetic errors such as mutations, rearrangements, and breakage of genomic DNA. In humans, these can cause diseases or developmental abnormalities, such as cancer or birth defects. DNA replication is the process of DNA polymerase enzymes copying template DNA unwound by replicative helicases. Accessory proteins ensure that replication proceeds in a highly efficient and accurate manner in the eukaryotic cell. Timeless and Tipin proteins comprise the mammalian Fork Protection Complex (FPC). The FPC has been implicated in replication fork stability, DNA replication checkpoint activation, and proper sister chromatid pairing, mostly in fungal and nematode systems, although the mechanisms of action are still unclear. Human genome size and regulation add additional complexity to DNA transactions in mammalian cells; therefore it is important to characterize the mammalian FPC and determine its function in human DNA replication. We demonstrate that Timeless-Tipin complex in human cells preserves genome integrity during DNA replication. We establish localization of human FPC proteins specifically to the DNA replication fork on chromatin during S-phase. We show that Timeless-Tipin act to prevent DNA damage accumulation by allowing proper recovery from genotoxic insults. We also demonstrate that proper FPC function is important for the regulated pairing of sister chromatids during S-phase. We have linked FPC to cohesion establishment through interaction with cohesin proteins. We have uncovered a physical and functional interaction between Timeless and ChlR1, a helicase known to promote sister chromatid cohesion. Additionally, we have elucidated a role for Timeless in replication of telomeres. The replication of telomeres is substantially delayed after Timeless knockdown. In the absence of Timeless, telomeres shorten and accumulate DNA damage. We have shown that Timeless regulates telomere replication through interaction with telomere repeat binding proteins. Taken together, these data are consistent with a genome-wide role for Timeless in replication fork stabilization and DNA replication fork progression at difficult templates throughout the genome. Thus, we have established Timeless as an important coordinator of multiple processes with DNA replication.
Behavioral dissociation of orbital-medial and dorsolateral frontal lobe functioning in patients with intermittent explosive disorder
Authors:   , Best Mary Helen , Williams Joseph M
Published: July 2024

Aggression can be defined as an intense, harmful, and hostile action taken against oneself, another person, or an object. Aggression can be expressed verbally, indirectly or directly to another person. The DSM-IV has only one disorder with aggressive behavior as a primary symptom, Intermittent Explosive Disorder (IED). Criteria for IED include several episodes of impulsive aggressive behavior out of proportion to provocation. To date no study has examined the neuropsychological profile of subjects with IED. Humans and animals with lesions to the orbital/medial prefrontal cortex and associated limbic brain areas display impulsive aggressive behavior. Associated cognitive and perceptual deficits include emotional misperception, disinhibition, and impaired smell identification. The goal of the present study was to test the hypothesis that subjects with IED would have a cognitive profile similar to patients with lesions to orbital/medial prefrontal cortex. Subjects with IED (N = 24) and age-, education-, and IQ-matched control subjects (N = 22) were given tests of facial expression identification, response inhibition, and smell identification. These tests have been linked to the integrity of the orbital/medial prefrontal cortex. To determine specificity of prefrontal dysfunction, subjects were given control tests of working memory linked to the dorsolateral prefrontal cortex. Subjects with IED performed significantly worse than controls on the three orbital/medial tasks. Subjects with IED were impaired at identifying negative facial expressions and showed a bias to label neutral faces with a negative expression. IED subjects had difficulty learning associations and correctly altering their behavior in response to punishment in a simulated gambling task. They were also impaired at identifying odors. Subjects with IED performed similar to controls on the dorsolateral control tasks of working memory. Subjects with IED showed a pattern of impairments that resembled impairments in patients with orbital/medial prefrontal cortex lesions. However, the degree of impairments in IED was milder than patients with lesions. This study provides evidence for a mild dysfunction in orbital/medial prefrontal cortex in IED. This study has implications for psychotherapeutic interventions in IED. Future studies could more directly test the orbital/medial hypothesis in IED by functional neuroimaging of prefrontal cortex while subjects perform tests investigated in this study.
Modulation doped field-effect photodetectors
Authors:   , Romero Murilo Araujo
Published: July 2024

The dissertation is concerned with the modeling and characterization of MODFETs (Modulation Doped Field-Effect Transistors) as photodetectors. Analytical derivation revealed that the dominant photodetection mechanism in the devices is the internal photovoltaic effect, caused by hole accumulation in the GaAs layer. The illumination acts as an additional terminal, producing a shift in the gate to source bias point, through which the device can be controlled. The MODFET photoresponse is characterized by a logarithmic dependence on light intensity and extremely high optical gain at low optical power levels. A responsivity in excess of 105 A/W was measured. The response speed of currently available devices is limited to the MHz range. Several device structures, designed to extend the electrical bandwidth while preserving gain over conventional photodiodes, are proposed. The experimentally observed negative photoresponse mechanism is explained and the optical control of a MODFET oscillator is demonstrated.
¿Tiene sentido que al tocarse dos frutos se genere una planta “mezcla” de ambos? Sensemaking en el análisis de Modelos de Reproducción Vegetal
Authors: Sánchez-Robles Jose Manuel , Martínez Pérez Leonardo Fabio , Martínez-Chico María
Published: July 2024

La existencia de concepciones alternativas y dificultades de aprendizaje asociadas a la reproducción vegetal pone de manifiesto la necesidad de revisar los procesos de enseñanza-aprendizaje y la formación docente que ofrecemos con el fin de promover su adecuada enseñanza. Una de las secuencias que diseñamos para formar maestros/as de Primaria a través de un enfoque de Indagación basada en Modelos, se centra en la reproducción sexual en plantas. En este trabajo se analiza una parte de la implementación de esta secuencia, centrándonos, por un lado, en los modelos iniciales identificados en las respuestas de 92 estudiantes a una pregunta contextualizada, y por otro, en el efecto que tiene una actividad colectiva orientada a la evaluación de modelos mediante el uso de analogías para identificar inconsistencias a través de "la búsqueda de sentido" o sensemaking con el fin de descartar las alternativas que carezcan de sentido.
Física del siglo XX en las pruebas de acceso a la Universidad. Un análisis comparativo entre comunidades autónomas
Authors: González García Francisco , García Sánchez Sergio
Published: July 2024

En este trabajo se realiza un análisis comparativo de las Pruebas de Acceso a la Universidad de la materia de Física de 2º de Bachillerato, entre los años 2010 y 2022, de las comunidades autónomas de Andalucía, Castilla-La Mancha, Extremadura y Murcia. El análisis se concreta en el bloque curricular de “Física del siglo XX” comparándose la estructura de la prueba, la presencia de contenidos y de los criterios de evaluación prescritos en la legislación educativa. Se analizaron 183 pruebas encontrándose 243 preguntas sobre dicho bloque. Se constata que no todos los contenidos y criterios están presentes y las diferencias existentes entre las comunidades en los diversos aspectos de las pruebas, sugiriéndose las implicaciones educativas que tales diferencias suponen para el sistema de acceso a los estudios universitarios en España.
Planificación y memoria de trabajo como variables predictoras del rendimiento académico en adolescentes de 12 a 17 años
Authors: Muchiut Álvaro Federico , Pietto Marcos Luis , Vaccaro Paola , Sánchez Belén
Published: July 2024

El objetivo principal de este trabajo fue analizar el valor predictivo de las funciones ejecutivas en relación con los cambios en el rendimiento académico entre adolescentes de secundaria a partir de la autoevaluación y de la evaluación de los padres. El estudio consistió en una investigación cuantitativa no experimental, descriptivo-correlacional de 265 adolescentes de entre 12 y 17 años. Los y las estudiantes evaluaron sus propias funciones ejecutivas utilizando la Escala de Autorreporte de Funciones Ejecutivas, mientras que sus padres/tutores las evaluaron con la Escala Parental de Funciones Ejecutivas. El estatus socioeconómico se obtuvo mediante la Encuesta de Nivel Socioeconómico, y el rendimiento académico se obtuvo a partir de los boletines de calificaciones. Los resultados mostraron una correlación positiva entre el rendimiento académico y las funciones ejecutivas, percibidas tanto por los adolescentes como por los padres; así como entre el rendimiento académico y el estatus socioeconómico. Además, el rendimiento académico fue significativamente explicado por el estatus socioeconómico y las actividades relacionadas con la memoria de trabajo y la planificación, percibidas tanto por los adolescentes como por los padres. Basándose en estos resultados, el estudio concluye que los adolescentes son capaces de reflexionar sobre la eficacia de sus funciones ejecutivas de forma relevante para su rendimiento académico, y que los cuidadores pueden proporcionar información relevante sobre las funciones ejecutivas de sus hijos. Además, los resultados destacan la importancia del estatus socioeconómico a la hora de examinar la relación entre las funciones ejecutivas y el rendimiento académico.
Determination of Nutrient Elements Content, Essential Oils Ratio and Biochemicals Composition of Origanum rotundifolium Boiss. and Origanum syriacum L.
Authors: Nohutçu Lütfi , Tunçtürk Murat , Şelem Ezelhan , Tunçtürk Rüveyde , Çınar Orçun
Published: July 2024

In the study, the biochemical composition of bioactive ingredients, essential oils ratio and compounds, mineral elements content, and antioxidant activities of two Origanum species (O.rotundifolium Boiss. and O. syriacum L.) were investigated. It has been observed that the total flavonoid and phenolic contents vary, with the amounts being 6.57 mg QE g-1 and 225.79 mg GAE g-1 for O. rotundifolium Boiss., and 184.65 mg QE g-1 and 114.46 mg GAE g-1 for O. syriacum L., respectively. The highest element contents have been determined for macroelement Calcium (Ca)> Potassium (K)> Magnesium (Mg); and for microelement Iron (Fe)> Manganese (Mn) > Zinc (Zn)> Copper (Cu)>, respectively. The essential oil yield was determined between 2.39% (O. rotundifolium Boiss) and 5.29% (O. syriacum L.). Essential oil compositions were determined by GC-MS (Gas Chromatography–Mass Spectrometry analysis). Besides, the major components found in two species were carvacrol, γ-terpinene and cymene. As a result of the study, O. rotundifolium Boiss. and O. syriacum L. species are rich in nutrients and biochemical content and can be used in many areas as an alternative food source.
Study of the prevalence of Hypopigmented Mycosis Fungoides among Patients Presenting Hypopigmented Lesions
Authors: Srisuttiyakorn Chutika , Bocam Patcharasiri
Published: July 2024

Background: Hypopigmented mycosis fungoides (MF) is a variant of primary cutaneous T-cell lymphoma. Although the prognosis of hypopigmented mycosis fungoides is excellent, the diagnosis is usually missed. Objective: The study aimed to identified the prevalence of patients with hypopigmented mycosis fungoides presenting hypopigmentation in Phramongkutklao Hospital, Bangkok, Thailand. We also reported the characteristic of hypopigmented mycosis fungoides among patients presenting hypopigmentation and compared clinical presentations between patients with a diagnosis of hypopigmented mycosis fungoides and patients with other diagnoses Materials and Methods: We conducted a retrospective among 56 patients presenting hypopigmentation and receiving skin biopsies at Division of Dermatology, Department of Medicine, Phramongkutklao Hospital, Bangkok, Thailand between January 2016 to December 2021. The data parameters including demographic data, clinical manifestations (symptoms, size and morphology of the lesions, e.g., scale, margin, erythema, atrophy, mottled hypopigmentation, involved body surface area and distribution, histopathologic reports, special stains, final diagnosis, further investigations, treatments, follow-up duration and result of the treatments were recorded. Results: The prevalence of hypopigmented mycosis fungoides among patient presenting with hypopigmentation was 16.1%. Compared with patients with other diagnoses, patients with hypopigmented mycosis fungoides usually had lesions with ill-defined margins (P-value=0.045) and presence of atrophy lesion (P-value=0.023). Conclusion: The prevalence of hypopigmented mycosis fungoides involved 16.1% of patients presenting hypopigmentation. The presence of ill-defined margins and atrophic lesions led to suspected hypopigmented MF in our study. This data could be useful in epidemiologic information and might be adapted when choosing lesions for biopsy to diagnose MF.
Challenges and Opportunities in Attention Deficit Hyperactivity Disorder in Developing Countries.
Authors: Fourie Pieter , Armstrong Julia
Published: July 2024

In the developing country a physician is faced with many challenges when seeing patients on the neurodiverse spectrum. Despite many well-known tools available, time restraints and lack of resources often results in sub-par diagnoses and continuation of care. Fortunately, with modern technology and the ever growing fields of machine learning and artificial intelligence, new developments have the possibility to ensure wider access to simplified and efficient tools with decreased need for specialist referral, helping to facilitate diagnosis, to reduce consultation time and costs and to simplify follow-up and monitoring.
Projection of Bipolarity to Mitochondria: GABA Shunt is related with Self pathology and Medical Comorbidity in Bipolar Disorder
Authors: Kesebir Sermin
Published: July 2024

The nature of the relationship with the self-object is the source of mental energy. At this point, the self is a spatiotemporal formation. The self has been found to be associated with the GAD enzyme activity responsible for GABA production at the molecular level. GABA is a metabolite of Krebs. Bipolar disorder is a biphasic state of energy dysregulation as a circadian rithms. Phasic nature of mitochondria to produce ATP may be crucial to the switching of affective states in bipolar disorder. The GABA shunt is an alternative energy production pathway that is activated in response to stress. The GABA shunt plays an important role in preventing the accumulation of reactive oxygen intermediates and cell death. On the other hand, GABA shunt impairs phosphorylation processes. Mitochondrial dysfunction is reflected in glucose, lipid and protein metabolism. A bipolar spectrum is possible at this point, including physical illnesses. A classification of mood disorders based on entropy levels is framed by medical comorbidity.
The Influence of Love for Work, Servant Leadership, and Perceived Organizational Support in the Happiness Level among Muhammadiyah Teachers
Authors: Aulia Aulia , Diawita Milenia , Riska Ahmad , Elisa Lia , Wafa Zaenal
Published: July 2024

Happiness is important in maintaining the stability of human resources, including in the educational sector. However, studies on the happiness at work are still neglected. In the organizational scale, the discussion on happiness is compelling as it relates to work achievement or productivity. Moreover, studies on factors affecting happiness at work are still limited, especially in teachers who work under the auspices of Muhammadiyah. The present study determines the influence of work passion, servant leadership, and perceived organizational support on teachers' happiness levels in the workplace. The study used quantitative research with a correlation method. The research population is teachers of 54 Muhammadiyah schools in Yogyakarta. The sample was determined using proportional cluster random sampling with 28 schools and 263 teachers. The instruments evaluated were the work passion (α=0.975), servant leadership (α=0.952), perceived organizational support (α=0.869), and happiness at work scales (α=0.877). The data was analyzed using multiple regression analysis. The results showed that work passion, perceived organizational support, and servant leadership influence Muhammadiyah teachers' happiness at work in Yogyakarta. The teachers' personal (work passion) and organizational (principal leadership style) factors at work are essential to pay attention to in order to increase teacher happiness.
Implications of Islamic Theology on The Psychoanalysis of The Character Ember from The Film Elemental: Forces of Nature
Authors: Haryanto Sri , El Syam Robingun Suyud , Munawaroh Hidayatu
Published: July 2024

Apart from being an entertainment source, movies can have a deep meaning that benefits life. Some films offer a multidimensional perspective that can be viewed from various aspects. This research explores the psychological condition of Ember, the main character in the film "Elemental: Forces of Nature," through the lens of Sigmund Freud's psychoanalysis and the implications of Islamic theology. The study employs a descriptive qualitative method and analyzes data collected from the film's script and related writings, focusing on Ember's personality and defense mechanisms. At the beginning of the movie, Ember exhibits an unbalanced interplay between her id, ego, and superego, manifesting in her struggle to control her emotions, particularly anger. Freud's psychoanalysis is a comprehensive method but heavily critiqued within Islamic theology for not addressing the aesthetic values of the soul, leading to a perceived dryness. The film portrays Ember as outwardly stable and obedient to her parents, yet internally, she harbors unresolved complaints. Her interaction with Wade, a character embodying the water element who is talkative and enjoys life, aids in stabilizing and enriching her character. The study underscores the Islamic belief that everyone is created in pairs, with diversity as a divine strategy for fostering complementary relationships. The findings highlight the significance of maintaining a balanced lifestyle and adhering to divine guidance for human well-being in the 21st century.
Pengungkapan Enterprise Risk Management Terhadap Nilai Perusahaan yang Dimoderasi Good Corporate Governance
Authors: Wibisono Bambang , Prabowo Tri Jatmiko Wahyu
Published: July 2024

Latar Belakang: Naik turun harga saham di tahun 2019 dan bersamaan dengan terjadinya pandemi, tentu memiliki dampak terhadap nilai Perusahaan.Turunnya harga batubara dan minyak mentah secara continue menjadikan penjualan juga ikut menurun yang berdampak turunnya nilai kepercayaan masyarakat terhadap nilai perusahaan.Tujuan: Penelitian ini bertujuan untuk mendeskripsikan dan menganalisis peran good corporate governance dalam memoderasi hubungan pengungkapan enterprise risk management terhadap nilai perusahaan.Metode Penelitian: Teknik pengambilan sampel yang digunakan adalah purposive sampling dan diperoleh sampel sejumlah 48 data yang berasal dari sampel perusahaan manufaktur sektor pertambangan yang terdaftar di BEI (Bursa Efek Indonesia) tahun 2019 hingga 2022. Data diperoleh dari annual report yang didapat melalui website www.idx.co.id dan Bloomberg. Pengujian hipotesis dalam penelitian ini menggunakan Satistical Package for Social Science (SPSS) versi 25 dengan model regresi linear berganda dan Uji moderasi.Hasil Penelitian: Hasil pengujian menunjukkan bahwa Enterprise Risk Management Disclosure berpengaruh positif signifikan terhadap nilai Perusahaan. Good corporate governance dengan menggunakan proksi dewan komisaris independen mampu memoderasi Enterprise Risk Management Disclosure terhadap nilai perusahaan. Keaslian/keterbaruan penelitian: Penelitian ini menambahkan variabel good corporate governance yang menggunakan proksi dewan komisaris independen. Riset dilakukan pada industri tambang yang terdaftar pada Bursa Efek Indonesia selama 3 periode dari tahun 2019 sampai 2022.
Wykorzystanie metody studium przypadku w badaniach szkoły
Authors: Tołwińska Bożena
Published: July 2024

Celem artykułu jest pokazanie różnych ujęć studium przypadku oraz różnych możliwości projektowania procesu badawczego z jego zastosowaniem, jako jednej z metod służących pozyskiwaniu wiedzy o rzeczywistości, m.in. o szkole. Analiza literatury ukazuje, że studium przypadku ma bardzo silną pozycję w metodologii badań społecznych i jest powszechnie stosowane przez przedstawicieli różnych nauk, co powoduje odmienności w jego rozumieniu. Stanowi to uzasadnienie dla poszerzania pola dyskusji i refleksji nad tą kwestią. W artykule zostaną przedstawione wybrane definicje studium przypadku, podstawowe założenia metodologiczne zastosowane w badaniach własnych w odniesieniu do reguł tej metody oraz dwa przykłady badań innych autorów, jako ilustracja możliwości różnorodnych ujęć procesu badawczego w jej ramach.
The Performances of Sorting Algorithms by Using Assembly Language
Authors: Balutoiu Victor Deian , Mafteiu-Scai Liviu Octavian
Published: July 2024

In many programs the data have to be sorted according to one or more criteria. Algorithmics offers us specific algorithms classified according to the order of complexity. But from this point to the realization of a concrete and efficient program for a specific set of data there is a long way. The choice between performance and flexibility of an application is not easy. This paper presents an experimental study that tracks the time performance of assembly language implementations in relation to C and Rust in cases of Bubble Sort, Insertion Sort and Quick Sort algorithms. Conclusions as well as future research directions are also included.
An Evaluation of the Concepts of Well-Being in Architecture and Design: A Theoretical and Conceptual Approach
Authors: Banu Burkut Emine , Yılmaz Nazende
Published: July 2024

This article aims to evaluate design approaches and publications related to well-being in architecture, interior architecture, and design. What is well-being for this purpose? What methodologies have been used in studies investigating the relationship between architecture, design, and well-being? Where have studies on the relationships between architecture, design, and well-being been conducted globally? Research data on well-being, including architecture and interior design, was searched in databases using keywords; architecture categories well-being and architecture, interior architecture, architectural design, design. The research utilized scientific mapping methods for analysis. This data analysis on architecture and well-being serves as an essential foundation for future research. According to the results of this research the most effective publications and keywords on well-being are revealed. In addition, this research provides an up-to-date perspective on the subject.
Exploring the Narrative Account of Vascular Dementia: Prequels, Sequels, Parasequels and Consequels in Neurodegenerative Development
Authors: Hwee Chia Kok
Published: July 2024

This paper explores the narrative account of vascular dementia, using prequels, sequels, parasequels and consequels to illustrate its neurodegenerative development. It analyzes vascular aphasia, lethologica, prosopagnosia, and Charles Bonnet’s Syndrome, unravelling the progression of vascular dementia. Drawing from literature and clinical observations, it examines the condition's narrative arc, showcasing diverse manifestations and trajectories. By conceptualizing vascular dementia narratively, the paper offers insights into cognitive impairment's evolving nature and the interplay of neurological symptoms. Understanding this narrative framework enhances clinical comprehension and promotes holistic approaches to diagnosis, treatment, and caregiver support.
Chaotic generation in a crossflow laser with spatial nonuniform excitation
Authors: Loskutov Aleksandr ,   Lomonosov Moscow State University, Mushenkov Andrei , Odintsov Anatoly , Fedoseev Anatoly ,   Lomonosov Moscow State University,   Lomonosov Moscow State University,   Lomonosov Moscow State University
Published: July 2024

Dynamics of a model of the continuously pumped crossflow laser with the unstable cavity is investigated. Depending on the control parameter characteristics of the chaotic lasing and onset of chaos are described. Projection of the corresponding attractors, Poincare maps, correlation and embedding dimensions are presented. It is shown that the chaotic lasing appears via destruction of а quasiperiodic behaviour with two incommensurate frequencies. By calculation of е attractor dimension qualitative changing in the corresponding chaotic regimes is described.
On the theory of the quasi-optical resonators with periodical structures
Authors: Bogomolov Genrih ,   P.L. Kapitza Institute for Physical Problems of Russian Academy of Sciences, Kleev Andrej ,   P.L. Kapitza Institute for Physical Problems of Russian Academy of Sciences
Published: July 2024

In the present paper we discuss the results of а numerical investigation of the quasi-optical resonator with a periodical structure (a grating) used at the relativistic orotron. To obtain its operation in the sub-millimeter wavelength range (the wavelengths from 20-30 microns to 1 mm) it is possible to use an electron beam with several MeV energy. A periodic structure with the period close to the wavelength must be used for the relativistic electron beams. A method for numerical analysis of the quasi-optical resonator with а corrugated mirror are presented. The method under consideration is applied to the case when the period of the structure is close to the wavelength. It has been found that there were some resonance effects which took place when the period of the corrugation was close to the wavelength. For instance, it has been shown that for a specific value of the corrugation depth, the Gaussian beam was reflected from the structure without distortion. The calculations demonstrate that when the depth is close to this specific value, the quasi-optical resonator losses are being changed drastically. The optimal grating parameters which provide maximum field-beam interaction and minimal losses have been obtained.
To the History of the Formation of Russian-Mountain Trade in the North
Caucasus at the End of the 18th - Beginning of the 19th Century
Authors: Anufrienko Maksim S.
Published: July 2024

The article reveals the features of the formation of trade in the
conditions of the North Caucasus, when many unfavorable circumstances
complicated this process. In addition to the landscape obstacles that
prevented the construction of an extensive network of roads in mountainous
areas, the epidemiological threat posed a significant danger. To stop the
spread of infectious diseases, quarantine lines were erected, where it was
necessary to maintain the isolation periods necessary to detect a possible
infection. The funds spent on such measures, as well as the loss of time by
merchants, affected the final price of the goods, making them more
expensive. For the authorities, trade was a tool of political influence over
local peoples. Hence the desire to monopolize contacts between the
mountaineers and residents of the settlements bordering them. This approach
could influence the range of goods offered, determine the equivalent of
their value, limiting the use of money in trade transactions. Gradually, a
model of interaction was developed on the established trading platforms
(exchange yards, salt stores, fairs). Efforts were made to prevent
conflicts, and if they occurred, mechanisms were created to resolve mutual
claims. Commodity-money relations replaced natural exchange.
Análise de Soluções Integradas de Geração Distribuída, Armazenamento de Energia e Veículos Elétricos no Contexto da Tarifa Branca
Authors: Rodrigues Aline , Rampinelli Giuliano Arns , Bremermann Leonardo Elizeire
Published: July 2024

A mitigação das emissões de gases de efeito estufa e de poluentes ambientais é essencial para a conservação e preservação do meio ambiente. Isso requer uma redução urgente na dependência de recursos fósseis em energia e transporte. Nesse contexto, visando o desenvolvimento sustentável, este artigo propõe a integração de sistemas fotovoltaicos de geração distribuída, armazenamento de energia e veículos elétricos como uma alternativa para reduzir a demanda na rede elétrica durante os horários de pico. O estudo almeja simular e analisar as variações de consumo e faturamento de energia elétrica de cinco classes de consumidores atendidos em tensão monofásica, considerando tanto a tarifa branca quanto a convencional. Dois cenários foram considerados: o primeiro consiste na classe de consumidores apenas conectada à rede elétrica, com sistema fotovoltaico conectado à rede (SFCR), e com SFCR com bateria integrada ao inversor com capacidade de 2, 4 e 10 kWh. O segundo cenário contempla o veículo elétrico como carga para o sistema, mas também como mecanismo de armazenamento e gerador de energia nos horários de ponta, como proposto na tecnologia veículo para a rede. Os resultados apresentaram o menor valor de fatura das classes de consumidores 1, 2, 3 e 4 com SFCR e bateria de 10 kWh no âmbito da tarifa branca no primeiro cenário. No segundo cenário, a tarifa branca foi viável para todas as configurações propostas. Isso ressalta a viabilidade da tarifa branca quando ocorre uma redução significativa do consumo noturno, nos horários de ponta e intermediários, em conformidade com as tarifas mais elevadas aplicadas nessa modalidade.
Exploration of the Impact of the COVID-19 Pandemic on Allied Health Students; Practice Placement Experiences
Authors: Tan Garret
Published: July 2024

The COVID-19 pandemic was an unexpected event, significantly impacting global populations. Due to its sudden occurrence, it has affected pillars of world stability, namely, healthcare. Not only has it stretched healthcare systems beyond their capacity, but it has disrupted its daily protocols and activities. As a result, adaptations to tackle this pandemic have been implemented, putting healthcare education, specifically, practice placements as a lesser priority; affecting students in a myriad of ways. Nevertheless, guidance has now been provided to allow clinical placements to continue. However, these changes have potentially limited students in their learning, posing the question of clinical sufficiency and competency. Hence, this qualitative study aims to understand the specific changes to Trusts and how students adapted to fulfil their module criteria and learning outcomes. A convenience sample of physiotherapy and occupational therapy students was recruited; from it, 18 interviews were then conducted. Transcriptions, coding and thematic analysis identified four main themes of learning opportunities, organisational changes, adaptations and mental wellbeing, thus providing clarity regarding how students successfully completed and met their placement learning outcomes despite organisational changes. However, as a result of these changes, mental and physical wellbeing has also been affected. The findings did shed light on which changes were helpful and which needed modification. Hence, future research was suggested to gain a more holistic understanding of the needs of students and other effective coping mechanisms, providing a more balanced placement experience during these uncertain times.
The Effect of Self-esteem on Stress and Coping Mechanisms among Nursing Students during Clinical Training in Palestinian Universities
Authors: Dreidi Mutaz , Abed Duaa , Salameh Haya , Abu Sbeih Inas , Asmar Saja , Salameh Sewar , Asmar Imad , Yaseen Khalid , Al-Mahmoud Omar
Published: July 2024

Nursing students are exposed to a variety of stressors during their clinical training. The impact of stress must be considered as an important factor that may have negative impact on clinical performance and patient care. The purpose of this study was to identify the relationship between self-esteem and stress and coping mechanisms among nursing students during clinical practice. A descriptive-correlational study was used in the study; a self-reported questionnaire was used to collect the data. A convenience sample of 300 baccalaureate-nursing students from Palestinian universities and had clinical training in governmental and/or private hospitals participated in the study. The most common type of stressors perceived was stress from taking care of patients (Mean= 9.8), followed by stress from instructors and nursing staff (Mean= 8). Problem solving was the most prevalent coping strategy used by the participants (Mean= 14.2), followed by staying optimistic (Mean= 9). The results showed that avoidance, and transference have significant positive correlations with all stressors (p < 0.05), while self-esteem has significant negative correlation with all stressors. The findings of this study revealed that nursing students experienced mild to moderate stress, and the most prevalent form of stresses experienced was stress from taking care of patients, followed by stress from instructors and nursing staff. Students commonly used problem solving followed by staying optimistic to cope with their stress, and they found these methods to be effective.
Promoting the Wellbeing of Physiotherapy Students on Placement:
Authors: Rhodes Jenna , Gill Louise , Thoms Alicia
Published: July 2024

The current healthcare workforce crisis in the United Kingdom has highlighted the need to equip graduates with the skills to maintain their personal wellbeing whilst working in increasingly pressurised environments. The Placement Wellbeing Project (PWP) is an intervention designed to support the wellbeing of physiotherapy students during studies, while on placement and as they enter the workforce.
This action research project used a single group, repeated measures design. Ethical approval was gained from the [redacted] ethics committee. On recruitment, participants were given the Placement Wellbeing Toolkit [toolkit link available but redacted as not anonymous to author or organisation] and took part in a pre-placement peer group discussion and a post-placement de-briefing session. Outcomes were measured using the Placement Coping Scale (PCS) and the General Self-Efficacy Scale.
Significant improvements were observed in the total PCS score (Friedman's test χ2(2) = 19.75, p = 0.000) and all individual items of the PCS from baseline to post-placement. Post hoc analysis detected significant improvements between baseline and pre-placement total PCS scores (p = 0.005). Total GSE scores improved significantly from baseline to final measure (Wilcoxon sum-rank test Z = 2.105, p =.035). 
To develop a resilient future workforce we need to ensure that students are well prepared for challenges and supported to maintain their wellbeing on placement. The results of this study indicate that physiotherapy students may benefit from interventions to develop positive coping strategies for placement.
Career motivation of 1st year nursing and midwifery students
Authors: Wareing Dr Mark , Newberry-Baker Ria , Sharples Dr Adrienne , Pye Sarah
Published: July 2024

This paper presents findings from a cross-sectional study into the motivational factors of students who chose nursing and midwifery as a career.
189 students from the University of Bedfordshire (UoB) and 223 students from Canterbury Christ Church University (CCCU) completed a questionnaire at the start of their studies in 2018. The findings are generated from the first stage of the Placement, Impact, Experience and Destination (PIED) study into student belongingness on placement and the influence of practice on the first career destination of newly qualified nurses and midwives.
An in-class questionnaire was administered to 1st year pre-registration adult, child and mental health nursing and midwifery students to identify the intrinsic and extrinsic factors that influenced their motivation to choose nursing or midwifery as a career.
A mix methods study design was adopted for the PIED study where participants completed a survey that collected quantitative and qualitative data and administered during the course induction period.
Motivation scores were found to be high in both cohorts, with students at both sites endorsing intrinsic motivational factors over extrinsic at statistically significant levels. The strongest intrinsic factors appeared to be a desire to help and care for people and play a useful role in society, whereas the strongest extrinsic factors were career stability and the ability to work in different regions and countries.
The study suggests that the influence of family and friends continues to exert a strong intrinsic motivational influence on the career choices of students, particularly those under the age of 25. Identifying the motivational factors of first year nursing and midwifery students presents employers with an opportunity to tailor strategies to recruit apprentices, enable placement partners to enculturate prospective employees into the workforce and understand the relationship between extrinsic factors and practice learning to successfully recruit graduates.