bluuebunny/crossref_metadata_2025 huggingface dataset:
In silico analysis of the antisickling activity of curcuminoids and curcumin metabolites and their ADMET properties
Authors: Mbadiko Clément , Ngbolua Koto-te-Nyiwa , Bongo Gédéon , Matondo Aristote , Kilembe Jason , Tshibangu Damien , Tshilanda Dorothée , Mbemba Théophile , Mpiana Pius
Published: May 2024

The aim of this study was to demonstrate the in silico the potential of curcuminoids and curcumin metabolites to inhibit the polymerization of HbS. Ten molecules were analyzed, including curcuminoids (curcumin, bisdemethoxycurcumin, demethoxycurcumin and cyclocurcumin) and curcumin metabolites (dihydrocurcumin, glucuronocurcumin, hexahydrocurcumin, hexahydrocurcumin, curcumin sulphate and tetrahydrocurcumin). In silico screenings were carried out by molecular docking to determine the free enthalpies of complexation and the interactions between different ligands studied and HbS. Moreover, in silico screening using the ADMET test was carried out to determine the pharmacokinetic profile of various compounds studied. The findings revealed that all the ligands can form stable complexes with HbS. The binding energies of the complexes formed between the ligands and Hb S ranged from -5.8 Kcal/moL to -8.1 Kcal/moL. These bindings between curcumin glucuronide and cyclocurcumin with HbS were stable compared with the other compounds (-8.1 Kcal/moL and -8.0 Kcal/moL). The in silico toxicity screening showed that the majority of ligands fulfilled the Lipinski and Veber rules. Thus, we believe that curcuminoids can individually or synergistically inhibit HbS polymerization and sickle cell sickling.
Stochastic modeling for energy generation in Sub Saharan Africa (Case Study of NAWEC Power Plants-The Gambia)
Authors: Appiah Simon Kojo , Opoku Richard , Frempong Nana Kena , Cham Amadou
Published: May 2024

This study aims to enhance the operational efficiency of NAWEC thermal power stations through a comprehensive approach involving stochastic modeling, analysis, and forecasting of energy generation (EG) and fuel consumption (FC). The historical power plant monitoring data underwent rigorous examination using both the bivariate autoregressive moving average model BARMA and artificial neural networks (ANNs). The investigation revealed that KT1ENG8 demonstrated exceptional performance in univariate analysis, as evidenced by the autoregressive moving average model, which provides minimized Akaike information criterion (AIC) and Kulback information criterion (KIC) values. Consequently, the effectiveness of the bivariate ARMA (p,q) model extends the top prediction of fuel consumption and energy generation from thermal power plants, providing valuable insights for thermal health and maintenance scheduling. To help the reader grasp the inherent dynamic of each of these strategies and their performances, a comparative synopsis of the outcomes is provided. The ANN results further enrich the study by presenting R2 values for different engines, offering ranked perspectives on their respective predictive capabilities. BK1ENG1 and KT1ENG8 have higher r2 values of 99.6% and 97.3%, respectively, than do the other power plant engines.
Going beyond the Black-Scholes option pricing model: financial rogue waves in quantum mechanics
Authors: Li Lingfei , Zhu Minting , Wu Jingyu , Wang Mancang , Xie Yingying
Published: May 2024

This paper proposes a nonlinear alternative for the Black-Scholes option pricing model that is defined as the Gross-Pitaevskii equation. It models the controlled Brownian motion of the financial market and describes the option price wave function in terms of the compound price and time. Here, we analytically predict the existence of a family of financial rogue wave solutions of the Black-Scholes equation in the form of complex rational functions by introducing small perturbation and using symbolic computation. The obtained solutions compose of a single symmetric soliton or several solitary peaks. The existence of non-zero offset parameters provides nontrivial alterations to higher order solutions as they would decompose into first order ones that can be used to simulate the evolution of financial risks. Financial rogue wave demonstrates a condition that investors may face a huge risk or return in the financial market, which might be an actual theoretical basis for the existence of it. Our study is the first to give solid proof of the connection between option pricing and quantum mechanics. This finding opens a novel path for the excitation and control of financial waveforms of quantum mechanic footprint and extreme financial crisis.
Out of Pocket and Catastrophic Health Expenditure in Tanzania: Recent Evidence on the Incidence, Intensity and Distribution
Authors: Massito John Geofrey , Hinju Gabriel John
Published: May 2024

Background Health care in most of the low-income countries (LICs) is financed mainly by out-of-pocket (OOP) expenditures. However, it is contentious that this payment mechanism tends to cause a massive burden on poor households. This study investigates the catastrophic impact of out-of-pocket health expenditures in Tanzania. Specifically, the study estimates catastrophic health expenditure levels, intensity and distribution.Methods Using the panel dataset of 2020/2021, the study applied descriptive analytical methods such as frequencies, means, proportions and concentration indices to investigate the incidence, intensity and distribution of catastrophic health expenditure in Tanzania.Results The study found that 21.9% (19.1% from rural and 24.6% from urban) of the respondents reported visiting a healthcare facility within four weeks before the survey. Over 50% (53.5% from rural and 57.4% from urban) reported an incidence of illness or injury within the same period. The study also found that among those who utilized health care, about 7.1% (8.4% from rural and 5.7% from urban areas) experienced catastrophic health expenditures. The results of the concentration index indicate that poor households have a higher probability of incurring catastrophic health expenditures than rich households, which is evident in the context of Tanzania, where health insurance is in the embryo stage of development.Conclusion We conclude that out-of-pocket health expenditures tend to lead to financial catastrophe for poor households, thereby exposing them to more poverty and forcing them to resort to coping mechanisms that compromise their welfare. This calls for a need to explore new and strengthened existing mechanisms for shielding poor households against out-of-pocket and catastrophic health expenditures.
Impact of intellectual property rights on foreign direct investment in Africa
Authors: Tsaurai Kunofiwa
Published: May 2024

The study investigated the impact of intellectual property rights on foreign direct investment (FDI) in selected African countries (Burkina Faso, Ivory Coast, Nigeria, Cameroon, Mali, Kenya, Burundi, Central African Republic, Rwanda, Senegal, Zimbabwe, and Tanzania). The purpose of the study is to develop property rights policies that encourages FDI in African countries. How FDI is influenced by the combination of trade openness and intellectual property rights was also examined using the same data set and econometric methods such as the dynamic generalized method of moments (GMM), fixed effects, and pooled ordinary least squares (OLS). Panel data ranging from 2005 to 2019 were used for the purposes of this study. A 1% increase in intellectual property rights led to a 22.73% increase in FDI inflows under the dynamic GMM and a 45.55% increase in FDI inflows under the random effects. These results show that intellectual property rights significantly enhanced FDI under the random effects and dynamic GMM. FDI was insignificantly enhanced by intellectual property rights under the pooled OLS and fixed effects methods. A 1% increase in complementarity between intellectual property rights and trade openness (complementarity term) pushed up FDI inflows by 17.78% under the dynamic GMM, whilst a 1% increase in the complementarity term increased FDI inflows by 16.72% under the fixed effects. In other words, dynamic GMM and fixed effects approaches show that the complementarity component significantly improved FDI inflows. The paper recommends implementing the best property rights strategies to improve FDI inflows into African countries.
AcknowledgmentThe author appreciates the moral support from the University of South Africa, his employer.
CHEMICAL CONSTITUENTS, ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF Pavonia glazioviana Gurke (Malvaceae)
Authors: Oliveira Micaelly , Chaves Otemberg , Teles Yanna , Fernandes Diégina , Macaúbas‑Silva Camila , Queiroz Wallace , Lima Jéssica , Mazzotti Maristela , Lima Edeltrudes , Fernandes Givanildo , Conceição Adilva , de Souza Maria
Published: May 2024

Species from Pavonia genus (Malvaceae) are traditionally used as antioxidant, n‑anti‑inflammatory and antimicrobial remedies. Previous studies have revealed their diversity of specialized metabolites widely used in the development of new medicines. This is the first study on Pavonia glazioviana Gurke, a Brazilian species known as “Malva‑da‑Chapada”. The research led to identify fifteen compounds: 132‑(S)‑hydroxy‑pheophytin a; and 132(S)‑hydroxy‑173‑ethoxyphaeophorbide, n‑decanol, cycloart‑23Z‑ene‑3β,25‑diol, cycloart‑24S‑25‑ene‑3β,24‑diol, sitosterol‑3‑O‑β‑D‑glucopyranoside, stigmasterol‑3‑O‑β‑D‑glucopyr anoside, quercetin, acacetin, kaempferol, tiliroside, 5‑hydroxy‑3,7,8,4’‑tetramethoxyflavone, 5,7‑dihydroxy‑3,8,4’‑trimethoxyflavone, 5,7‑dihydroxy‑4’‑methoxyflavone, 5,7,4’‑trihydroxy‑3,8‑dimethoxyflavone and 5,7,4’‑trihydroxy‑3‑methoxyflavone. The major flavonoids were tested for their antimicrobial activity, and the compound 5,7‑dihydroxy‑3,8,4’‑trimethoxyflavone showed strong activity against Escherichia coli (MIC = 512 μg mL‑1), Pseudomonas aeruginosa (MIC = 512 μg mL‑1), Candida albicans (MIC = 512 μg mL‑1), Candida tropicalis (MIC = 512 μg mL‑1), Candida parapsilosis (MIC = 512 μg mL‑1), Aspergillus flavus (MIC = 512 μg mL‑1) and A. fumigantus (MIC = 512 μg mL‑1). The total phenolic content, flavonoid content, and radical scavenging potential were determined showing its great production of phenolics and flavonoids, along with interesting radical scavenging potential (DPPH EC50 = 6.36 ± 0.029 mg mL‑1). Our findings contributed to characterize P. glazioviana as a source of methoxylated flavonoids with antimicrobial potential.
Notes, Resolutions, and States in the System of Normative Legal Acts of the Russian Empire in the Early XIX Century
Authors: Minnikes Irina
Published: May 2024

In the early XIX century, the legal practice of the Russian Empire used several forms of normative legal acts. The legalized forms were provided for by Article 53 of the Code of Laws of the Russian Empire. The list included manifestos, decrees, instructions, etc. The author matched normative legal acts with the legal prescriptions that implemented them, as well as identified the forms of normative acts that were not provided for by the Code of Laws. The Complete Collection of Laws of the Russian Empire also contained some other forms of normative acts, not mentioned in the Code. These other forms included timesheets, posters, plans, journals, etc., approved by the Emperor. States, resolutions, and notes were the most popular variants. States determined the composition of a specific business entity or element of a state mechanism, e.g., a ministry, an office, a police or military unit, etc. Sometimes, they indicated positions and corresponding salaries. Resolutions were Emperor’s written responses to an action (message or act) of a government representative. Notes were proposals of specific measures and actions sent to the Emperor by a government representative. The Emperor gave them legal force with certain formulas, e.g., To Execute or So Be It. These forms of acts were quite wide-spread during the reform period. The article describes the place of states, resolutions, and notes in the system of normative acts, as well as provides their quantitative analysis.
Potassium ferrate's disinfecting ability: a study on human adenovirus, Giardia duodenalis, and microbial indicators under varying pH and water temperature conditions
Authors: Boczek Laura A. , Ware Michael W. , Rodgers Mark R. , Ryu Hodon
Published: May 2024

Ferrate (Fe(VI): HFeO4− /FeO42−), a potent oxidant, has been investigated as an alternative chemical disinfectant in water treatment due to its reduced production of disinfection by-products. In this study, we assessed the disinfecting ability of potassium ferrate against a variety of microorganisms, including waterborne pathogens, under varying pH and water temperature conditions. We presented CT values, a metric of ferrate concentrations (C) and contact time (T), to quantify microbial inactivation rates. Among the tested microorganisms, human adenovirus was the least resistant to ferrate, followed by waterborne bacteria such as Escherichia coli and Vibrio cholerae, and finally, the protozoan parasite Giardia duodenalis. We further investigated the impact of two pH values (7 and 8) and two temperatures (5 and 25 °C) on microbial inactivation rates, observing that inactivation rates increased with lower pH and higher temperature. In addition to showcasing ferrate's capacity to effectively inactivate a range of the tested microorganisms, we offer a ferrate CT table to facilitate the comparison of the effectiveness of various disinfection methods.
Anthropogenic Gadolinium Anomalies in an Alluvial Plain with On-site Wastewater Treatment Systems in Campinas, SP, Brazil
Authors: Abreu Ana Elisa Silva , Enzweiler Jacinta , Yoshinaga-Pereira Sueli , Rupias Osvaldo Jorge Brito , Marques Adriana , Miguel Miriam Gonçalves , Alencar Joana de Miranda
Published: May 2024

Gadolinium anomalies have become a well-established marker for the pollution caused by wastewater, but there is not yet a standardized method to estimate the anomaly. Here, we compare four different published equations, distinct threshold values and reference normalizing values to estimate Gd anomalies by applying them to the results of a hydrochemical investigation in an alluvial aquifer with on-site sanitation systems. We measured traditional wastewater markers (such as electric conductivity, NO3_N, NH4–N, Cl-) and REE in groundwater samples collected from hand-dug wells in two seasons. The ratios of Gd normalized measured concentrations to Gd normalized geogenic concentrations (GdSN/Gd*) estimated with the various methods ranged from 0.7 to 2.8. It turned out that the choice of the equation and the threshold value can affect the decisions about anthropogenic pollution’s occurrence (or not). The normalizing values did not play a significant role in the decision. Based on measurement uncertainties and on the interpretation of hydrogeological conditions in the study area, a threshold value of 1.3 for defining anthropogenic Gd anomalies was deemed adequate for the study area. The occurrence of Gd anomalies higher than 1.8 in two wells, one in each season, reinforces the hypothesis that the groundwater is contaminated by the on-site sanitation systems in the study area, as intermittent detection of anthropogenic Gd is a characteristic of this pollution source.
Mining's legacy: Unraveling the impacts of acid mine drainage on the rivers and streams of the Santa Catarina coal region, Brazil
Authors: Cardoso Albert Teixeira , Fan Fernando Mainardi
Published: May 2024

Acid Mine Drainage (AMD) is a major environmental concern associated with coal mining activities, leading to the deterioration of water quality and posing significant risks to aquatic ecosystems and human health. In this study, we analyzed the physicochemical parameters of water samples collected from rivers and streams affected by mining in the Santa Catarina coal region, Brazil, to assess the extent and severity of AMD impact. Our findings reveal a substantial increase in element concentrations, including Fe, Mn, Al, and major cations (Na, Mg, Ca, and K), with some values exceeding background levels by several orders of magnitude. The majority of the samples exhibited acidic pH values, with only 24% and 34% within the limits established by the Ministry of Health and the geochemical background, respectively. Strong correlations between physicochemical parameters, such as pH and EH, and between acidity, sulfate, and metals, highlight the role of pyrite oxidation and mineral dissolution in generating AMD. Although most samples presented values within the established limits for toxic metals (Cu, Cd, Pb, As, and Hg), high concentrations of Zn were observed, exceeding regulatory and background limits. The results of this study emphasize the need for continuous monitoring and assessment of water quality in the region and contribute to a deeper understanding of the extent and severity of AMD in the Santa Catarina coal region.
Prevalence of Pulmonary Hypertension among Sudanese Patients with Sickle Cell Disease
Authors: Elfaki Yousif Ahmed , Ibrahim Ahmed Saadeldin , Merghani Tarig Hakim
Published: May 2024

Background

Sickle Cell Disease (SCD) is a hereditary condition characterized by aberrant red blood cell morphology, leading to persistent hemolytic anemia. The consequential impact of SCD on the pulmonary vasculature can result in pulmonary hypertension (PHT), a severe complication that detrimentally affects the well-being and survival of individuals with SCD. The prevalence and risk determinants of PHT in SCD patients exhibit variations across diverse geographical regions and populations. This study aims to ascertain the prevalence of PHT among Sudanese SCD patients and identify associated factors.

Methods

A cohort of thirty-one adult sickle cell disease (SCD) patients, as confirmed by hemoglobin electrophoresis, were recruited for participation in this cross-sectional study. Comprehensive data encompassing demographic, clinical, and laboratory parameters were collected. Doppler echocardiography was employed to quantify pulmonary arterial systolic pressure (PASP) and evaluate right ventricular size and function.

Results

Within our cohort, the prevalence of PHT was 29%. Active cigarette smoking demonstrated a significant association with PHT (P=0.042), while hydroxyurea therapy exhibited no noticeable impact on PHT (P=0.612).

Conclusion

Our investigation revealed a PHT prevalence of less than one-third in our SCD patient population, aligning with prior studies. Notably, independent of other factors, cigarette smoking emerged as a distinct risk factor for PHT in SCD patients. This highlights the potential utility of smoking cessation as an intervention to delay the onset of this condition. However, further research is imperative to elucidate the mechanisms through which smoking contributes to PHT development in individuals with SCD.
Corrigendum to: Review on Pyrazole Hybrids as Anti-microbial Agents
Authors: Goel Tanvi , Jain Naman , Bansode Deepali
Published: May 2024

Similar affiliation error appeared in the author's affiliation in the article entitled “Review on Pyrazole Hybrids as Anti-microbial
Agents”, published in Letters in Organic Chemistry, 2024, 21(4), 320-332 [1].

Details of the error and a correction are provided here.

Original:

Author Affiliation: 1Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be) University, Poona College
of Pharmacy, Pune, India; 2Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be) University, Poona
College of Pharmacy, Pune, India

Corrected:

Author Affiliation: 1Department of Pharmaceutical Chemistry, Bharati Vidyapeeth (Deemed to be) University, Poona
College of Pharmacy, Pune, India

We regret the error and apologize to readers.

The original article can be found online at https://www.eurekaselect.com/article/133287
Effects of Activation Energy and ThermoConvection of Nanofluid Flow
Authors: Chatterjee Sewli
Published: May 2024

Nonlinear mixed convection in magnetohydrodynamic thermo-convection nanofluid
flow is addressed. Flow is induced by a stretched surface. Chemical reaction effects on the
activation energy of the species concentration of Arrhenius are considered. The nonlinear
governing equations are converted to a dimensionless ordinary system through adequate
transformations. The solutions of nonlinear dimensionless expressions are computed by
employing the spectral quasilinearization method. A consequence of various parameters
involved such as velocity, concentration, and thermal field has been reported graphically.
Concentration has the reverse trend for both random motion and thermophoresis variables.
Effect of Casson Nanofluid's Outer Velocity with Melting Heat Transmission beyond a Stretching Sheet
Authors: Poply Vikas , Mondal Sabyasachi , Kumar Parveen
Published: May 2024

An analysis was conducted to observe the collective consequence of the melting
procedure across a stretching sheet in a Casson nanofluid with outer velocity. The outcomes of
melting heat parameter (M) and Casson parameter (β) are shown in this analysis. The leading
PDEs are moulded in ODE with similarity variables. The numerical results of moulded ODE
are given by the RKF scheme with shooting procedures. Important parameters of the nanofluid
are examined and graphically displayed. Tables are used to display the Sherwood number,
Nusselt number, and skin friction coefficient based on different nanofluid characteristics. The
development of cooling systems that raise the heat transmission belongings of nanofluids and
increase engineering potential will be greatly aided by this research.
A Pharmaceutical and Analytical Study on Palasha Kshara
Authors: Manju Pilania  , Aslam Khan  , Mahesh Dixit  , Hari Mohan Meena
Published: May 2024

Kshara is an important dose type stated in Ayurveda that is made from plant ash. Kshara has some similar qualities, such as an alkaline nature, water solubility, and a pale colour. Kshara has an advantage over all surgical and parasurgical measures since it can be used on skinny, frail individuals who are afraid of surgery. In classical writings, many herbs like as Apamarga, Snuhi, and Kadali Palasha are utilised to create Kshara, either individually or combined. The therapeutic usage of Kshara of different plants differs from one another, hence analytical research of each Kshara is required. Aims & Objectives The current study involves the preparation and analysis of Palasha (Butea monosperma) Kshara in order to better understand its properties. Material and Methods: Kshara preparation consists of several steps. In this study, Palasha Kshara is prepared using the general process described in the Sharangadhara Samhita. The prepared Kshara is submitted to several physicochemical evaluations, and the results are concluded. Results: The Palasha Kshara has physical features such as pale colour, strong odour, and softness to the touch. Chemically, it contains potassium, phosphorus, and sulphur, as well as trace amounts of other elements. The current study describes the methods and findings of Palasha Kshara's medicinal and analytical studies.
Critical review of Swetha Chandana (Santalum album l.) in Nighantus and Caraka Samhita
Authors: Vyshnavi Macharla  , Jagan lal Eslavath  , Swarupa Rani G  , Narasimha V  , Vijayalakshmi A
Published: May 2024

Chandana also known as Indian sandalwood, scientifically known as Santalum album Linn, is a medium sized tree belongs to the family Santalaceae. It is one of the oldest and most valuable sources of natural smell and has significant medical and commercial value. Chandana is used as a single drug and ingredient of numerous formulations for the betterment of lifestyle and treatment. Although, numerous studies regarding Chandana there still lies scope for evaluation and analysis on this topic.
A conceptual study on clinical application of Pratisaraniya Kshara Karma
Authors: Patel Vishva R  , Duragappa H
Published: May 2024

Ayurveda indeed delves deep into various therapeutic procedures, including Shastrakarma and Anushstra Karma. Kshara, considered one of the prime therapies, is classified into Paneeya and Pratisarneeya, with the latter further divided into Mridu, Madhyama and Teekshana.[1] Pratisaraniya Kshara involves diverse applications like Kshara application, Kshara Sutra, Kshara Varti, Kshara Plota, Kshara Taila infiltration and intralesional injection of Ksharodaka. Its primary applications encompass treating conditions such as Arsha (hemorrhoids), Bhagandara (fistula-in-ano), Nadivrana (sinus), Vidradhi (abscess), Dustavrana (non healing ulcer) and Charmakeela (warts). In the Sushruta Samhita, Acharya Sushruta elaborates on Kshara's multifaceted actions, attributing qualities like Chedana (cutting), Bhedana (penetrating), Lekhana (scraping), Dahana (caustic action), Pachana (digestive), Darana (breaking down), Vilayana (dissolving), Sodhana (purifying), Ropana (healing) and Stambhana (arresting).[2] Kshara's caustic nature plays a pivotal role in eliminating necrosed and infected tissues by inducing controlled tissue destruction.
Concept of Ahara Parinaman in view of Agni - A Physiological and Anatomical Review
Authors: Swati Gajanan Vedpathak  , Sayali Ramdas Walunj
Published: May 2024

Dosha, Dhatu and Mala are the basic elements of the body whose Source is Ahar Dravya i.e., Food is the basic source of energy for humans. Ayurveda states that our body gets it’s nutrition by Aahar Rasa. All the thirteen types of Agnis works on the four types of Ahar (Ashit, Peet, Leedh, Khadit) we take and are responsible in the formation of this Aahar Rasa. The process of Ahar Parinaman is continuing from birth until death at very minute level by Jatharagni, Bhutagni and Dhatwagni. The role of Agni is of immense importance for a healthy living because when the Agni is in normal state and if the individual consumes Matravat Ahar there will be proper digestion of food which forms Dhatusamyawastha ultimately leading to longevity. Impaired Agni is the root cause of all disease.
Role of Ayurveda medicine in the management of Amashaya Arbhuda w.s.r. to Carcinoma of Stomach
Authors: Shripathi Acharya G.  , Niranjan S  , Swapna Swayamprabha  , Rajeshwari S. Acharya
Published: May 2024

Due to faulty lifestyle, altered food habits and chronic psychological stress and mental depression, the incidence of Malignancy has been raised. Carcinoma of stomach is one such disorder which is commonly seen in Indian population. Symptoms like pain abdomen, burning sensation of the stomach, malena, weight loss, loss of appetite and anaemia are the common clinical features of this disease. Ayurveda medicine is beneficial in the cases with early diagnosis. After radical excision of the active lesion, palliative treatment can be given by using Ayurveda medicine. In Ayurveda, Vyadhi Pratyanika Aushadhi Prayoga, Yogasana and Pranayama, Assurance, changes in food and life style and Pathapathya Prayoga are advised. Medicines having actions like Anticancer, cytotoxic, Shoolahara, Antacid, antispasmodics, antidepressant, anxiolytic, antistress, adaptogenic, CNS depressant, Balya, Brimhala, Ojaskara, immunomodulator and cytoprotective actions are used as palliative measures. In this paper, the role of Ayurveda medicines in the management of Amashaya Arbhuda w.s.r. to carcinoma of stomach is discussed elaborately.
Preconceptional and Antenatal Care through Life Style with special reference to Sadvritta: A Scoping Review
Authors: Archana Dhananjay Inchekar  , Yogita Shrotriya  , Mrunal A. Tiwari
Published: May 2024

Sadvritta is a group of good conducts indicated to practice throughout life for everyone. Sadvritta plays significant role in prevention of all kind of diseases and in promotion of health. Female reproductive health is responsible for proper outcomes related to maternal and child health. There are guidelines in Ayurveda which consists of concepts of preconceptional, antenatal and post-natal health care of a mother and child. Wholesome life style with physical, psychological and verbal acts along with required medication and Panchakarma are mentioned. Special guidelines are mentioned for a couple as a Garbhadhan Vidhi (method of impregnation) which is supposed to follow at the time of preconception. Wholesome regimens at physical, mental and verbal level in life style of pregnant woman and a father at the time of conception is advised to maintain. Many factors described in Garbhini Paricharya and Sadvritta other than nutrition and medication are important for prevention. Emotional health of a mother is associated with the health of a child. Sadvritta and Ayurvedic life style consists guidelines which can reduce health issues due to stress. Many countries have developed national level health programmes for mother and child health. Goals of mother and child health programme emphases on antenatal, intra-natal and post- natal health care. Objectives of MCH programme are reduction of mortality and morbidity rates of mother and child. For it, care can be started at preconceptional phase. There may be a scope to advise Sadvritta guidelines to currently established MCH with Ayurveda health care. This article is an effort to view scope in MCH through Ayurveda and Sadvritta.
Female Menstrual Cycle and its relation to Tridosha and Sapta Dhatu - A Literary Review
Authors: Garima Malik  , Jitesh Kumar Panda  , Suniti Tanwar
Published: May 2024

Ayurveda is the life science which specifies its two purposes very clearly, first maintenance of one’s health and second curing the diseased condition. Concepts of Ayurveda are based on Tridoshas, Sapta Dhatus and Trimala. Their balanced state is said to be the characteristic feature of a healthy individual. Beside the Doshas and Sapta Dhatus, Upadhatu also mentioned which plays a major role in individual health. Artava, the foremost of its category is the Upadhatu of Rasa Dhatu plays a significant role in reproductive health and conception. The word Artava is used for menstrual blood in Ayurveda classics. The menstrual cycle in Ayurveda is known as Rituchakra, consisting three phases which are Rajashravakala, the Ritukala and the Rituvyatita Kala and shows a time period of 28 days. The normal characteristics of Shudh Artava has been mentioned in Ayurveda classics and deviation from this characteristic are shown due to Tridosha imbalance leading to further problems in Menstrual cycle and reproduction. This abnormality has been described as Artavdushti, Yonivyapad in Ayurveda classics where they are classified on the basis of the three Doshas (Vata, Pitta, Kapha). Considering the normal physiology of menstrual cycle, the bleeding phase is facilitated by Vata dosha, whereas the time period during ovulatory/proliferative phase shows the predominance of Kapha dosha. During the luteal phase, the Pitta Dosha comes into action. Most of the discomforts, abnormalities during menstruation are the outcomes of the Doshas imbalances.
Scientific applicability in day-to-day practice on Granthokta Garbhini Paricharya
Authors: Sakshi  , Jitesh Kumar Panda  , Suniti Tanwar
Published: May 2024

Achievement of motherhood is the cherished desire of every woman, as fetus depends upon mother for its nourishment, so health of pregnant women is most important as motherhood represents the bearing capacity of fetus inside the womb and delivery in a healthy status. There are many physiological and psychological changes occur in different stages of pregnancy in which some of them may ends up in discomfort and trouble. Acharyas have described Masanumasika Garbhini Paricharya in classical texts of Ayurveda for pregnant women that help in the development of fetus, healthy growth of fetus and care to mother. Garbhini Paricharya is nothing but the care given to pregnant women mostly through Ahara and Vihara. It is the daily regimen one should have to follow in the most delicate days of their life. The nine monthly diets are singularly unique in Ayurveda. This Paricharya changes in accordance to the growth of fetus in the womb and at the same time ensures health of mother. One can find remnants of dietetics (Paricharya) with older women and midwives but detailed and comprehensive diet plan as Paricharya is being practiced only by Acharyas. The main intension of advising Garbhini Paricharya is Paripurnatya (providing growth to fetus and mother), Anupaghata (pregnancy without complications) and Sukhaprasava (for normal delivery and healthy progeny). In this paper we are giving a broad expanse of the month wise diet as Garbhini Paricharya which can be modified according to the season, age, place, and digestive fire of pregnant woman.
Evaluation of the effect of Bala Tailam Nasya and Baladi Kwatha Pana in the management of Avabahuka - A Pilot Study
Authors: Tarendra Singh Songara  , Babita Dash
Published: May 2024

Avabahuka is a disease mainly affects the Amsa Sandhi (shoulder joint) which is painful, affecting the normal routine life style of an individual. The sedentary and restless lifestyles of people, and lack of priority to physical exercise, have an effect on the body that can cause disease. The main Dosha involved Avabahuka is Vatadosha and the treatment adopted for this are like Snayu-Sandhi-Asthi-Gata-Vata treatment. In Frozen Shoulder synovial inflammation occurs followed by capsular fibrosis. The shoulder joint becomes gradually painful and stiff with a reduction in range of motion. The current pilot study aim is to investigate the impact of Nasya with Baladi Taila and Baladi Kwath in Avabahuka. There are references for Nasya Karma in Avabahuka. Acharya Sushruta and others have considered it as Vataja Vikara. Amsa Shosha can be considered a pre-disease stage in which loss or dryness of the Shleshaka Kapha is found, as well as other symptoms like Shula during movement of shoulder joint.
Management of Dushtavrana (Non-Healing Ulcer) through Ayurveda - A Case Report
Authors: Priyanka Biradar  , Prasadshakti G. Gannur  , A. M. Madni
Published: May 2024

Shalyatantra is one among the Astang Ayurveda, the branch of Shalyatantra refers to surgical and parasurgical procedures in Ayurveda. Dusthavrana (non healing ulcer) are a frequently encountered problem in present era produced commonly as a complication of trauma or pathologic insult and it causes long term agony to the patient. The issue of non-healing ulcers management with Ayurvedic remedy is one of the major areas of the research and has come under increased study. This is a case report of 40-year-old female, who had an episode of Dushtavrana (non healing ulcer) and presented to the outpatient department with complaints of severe pain, itching and ulcer over right ankle region. The first line of management for Dushtavrana is Shodhana. Kalka is the specific treatment for Dusthavrana which is mentioned under Shodhana and Ropana Kriya of Saptopakrama. Yavadi Kalka is one of the formulations mentioned in Dwivraniya Chikitsa Adhyaya. Yavadi Kalka is simple, very cost-effective procedure. In the present case, Yavadi Kalka after Jaloukavacharana has shown assuring results in the management of Dushtavrana.
Role of Ayurvedic medicines with Panchakarma therapy in SLE w.s.r. to Aamvata
Authors: Veenu Yadav  , Shraddha Sharma  , Rajesh Meshram
Published: May 2024

Background: Autoimmune disorders occur when the body’s immune system is working hard to defend against potentially precarious substances our bodies such as allergens, toxins, infection or food but does not identify the difference between the invaders and own body cells. SLE is an autoimmune disease in which organs, tissues and cells undergo damage, mediated by tissues binding auto antibodies and immune complexes. SLE affects heart, joints, skin, lungs, blood vessels, liver, kidney and nervous system. Due to Piita Pradhantwa in SLE it can be correlated with Pitta Anubandhi Amavata as both are systemic autoimmune disease having involvement of mainly Pitta Dosha. Materials and Methods: A male patient with complaints of pain in multiple joints with swelling, recurrent mouth ulcers, weakness all over the body and erythematous rashes on both hands with some discharge came to OPD of PTKLS Hospital and diagnosed as Amavata and admitted in IPD of the Hospital and treated according to Ayurveda Protocol including oral medications and Panchakarma therapy. Result: Patient got symptomatic relief. Details of this will be discussed in full paper. Discussion: In Ayurveda, symptoms of Vata Kapha Anubandhi Amavata can be correlated with RA and symptoms of Pitta Anubandhi Amavata can be correlated with SLE as there is involvement of Pitta Dosha and Rakta Dhatu in SLE.
Management of PCOS Infertility then implementation of Garbhini Parichaya till Full Term by Ayurveda - Case Study
Authors: Ankita Pandey  , Anjana Saxena  , Sushil Mishra
Published: May 2024

Primary Infertility associated with recurrent pregnancy loss because of Viral infections like TORCH and Polycystic Ovarian Syndrome (PCOS) is a worrisome issue nowadays. In modern medicine, antiviral drugs are the main treatment for TORCH, causing various side effects. Ayurveda being preventive and curative medicinal branch, has good positive outcome in the treatment of TORCH induced BOH and infertility. The Garbhini Paricharya refers to the care given to pregnant lady. It has to be started as soon as the signs and symptoms of pregnancy are seen. The rate of abortions can be prevented by following proper antenatal care detailed in Ayurveda. Presenting a case report of 32-year-old female came to Govt. Ayurvedic college and hospital, Varanasi with 11 years of married life and history of two consecutive spontaneous abortions and wasn’t able to conceive since then. She was detected with PCOS and Positive TORCH infection. Her last USG findings dated 17/01/2023 was right ovarian- PCOS morphology & left ovarian- hemorrhagic cyst 54x60mm + subserosal uterine fibroid 20x27mm in fundal region with complaints of inability to conceive with complaints of delayed menses at interval of 2-6 months with prolonged bleeding with clots for 10-15 days for 7 years (after last abortion). Treatment protocol was based upon Samprapti Vighatan & focused on Prakriti of patient, Dosha Pradhanya Lakshana & Dosha Dushya Sammurchana. She was treated with Jalkumbhi Kshar with Varunadi Kwath for her fibroid and Pushpadhanva Rasa, Kanchanar Guggulu, Ashokarishta etc along with Nasya, Matra Basti and Uttar Basti. After 4 months of treatment, patient was treated successfully with Ayurvedic intervention and Garbhini paricharya with conception and delivery of a full-term healthy baby boy.
Efficacy of Marma Chikitsa in the management of Avabahuka (frozen shoulder) - A Single Case Study
Authors: Aayushi Chouhan  , Rita Marwaha  , Nisha Bhalerao  , Swatantra Kumar Chourasia
Published: May 2024

Avabahuka (frozen shoulder) is a type of Vata Vyadhi caused by vitiated Vata Dosha with Anubhandha of Kapha Dosha. The symptoms of Avabahuka can be correlated with the symptoms of adhesive capsulitis, which is commonly known as frozen shoulder. Being a disease of shoulder joint, which has the greatest range of motion, it seriously affects routine day-to-day activities. A 56-year-old female came to the OPD of Pt. Khushilal Sharma Government Ayurvedic College and Hospital, Bhopal (MP) with pain and restricted movement in the right shoulder since 6 months, having undergone conventional treatment without any significant improvement. In this case study effect of Marma Chikitsa in the management of Avabahuka (frozen shoulder) is evaluated. The patient was treated with Marma Chikitsa for 10 days. The range of movements improved gradually from 45 to 123° for abduction, 102° to 165° for flexion, 53 to 65 for external rotation, and 30° to 45° for extension. VAS score for pain in the right shoulder was 7 before treatment, which came down to 4 after first course of the treatment regimen and gradually to 3 after completion of the treatment. The study suggested that Marma Chikitsa may be used for relieving symptoms of Avabahuka; however, study on large population was suggested.
Opioid overdose response and health information complexities: A pilot study on Naloxone kit design
Authors: Harvey Gillian S , Knox Michelle , Hyshka Elaine , Rowe Aidan , Lefsrud Lianne , Sommerfeldt Susan , Forhan Mary
Published: May 2024

Between 2016 and 2018, more than 11,000 Canadians and 136,000 Americans died from accidental opioid overdoses—triple the number of deaths caused by motor vehicle accidents. This public health crisis is so severe that by 2017, Canadian life expectancy stopped increasing for the first time in four decades. The distribution of Naloxone kits (emergency first aid for opioid overdoses) has revealed the need for alternative ways to get training, kits, and education to audiences who are at risk of overdose. We report on an interdisciplinary study designed to better understand the barriers to adopting and using Naloxone kits for opioid overdoses. Data from the pilot phase of our research suggest that several opportunities exist in which design methods can help identify and address these barriers.
Mistrust in health care as a potential motivator for vaccine uptake: A patient perspective
Authors: Montgomery Charisse
Published: May 2024

The prevalence of conversations about trust in health care seems to have increased since the onset of the COVID-19 global pandemic. Frequently, the discussion focuses on vaccine hesitancy among people of colour in the US and historical reasons for their mistrust in the healthcare system. The premise has been that increasing trust in health care will increase the likelihood that African Americans will take the COVID-19 vaccine. Conversely, focusing on the anxieties and realities caused by persistent disparate outcomes might offer an honest and transparent way to promote vaccine uptake, while acknowledging the systemic issues that erode trust.
User-Centered Framework for Implementation of Technology (UFIT): Development of an Integrated Framework for Designing Clinical Decision Support Tools Packaged With Tailored Implementation Strategies
Authors: Ray Jessica , Finn Emily Benjamin , Tyrrell Hollyce , Aloe Carlin F , Perrin Eliana M , Wood Charles T , Miner Dean S , Grout Randall , Michel Jeremy J , Damschroder Laura J , Sharifi Mona
Published: May 2024

Background

Electronic health record–based clinical decision support (CDS) tools can facilitate the adoption of evidence into practice. Yet, the impact of CDS beyond single-site implementation is often limited by dissemination and implementation barriers related to site- and user-specific variation in workflows and behaviors. The translation of evidence-based CDS from initial development to implementation in heterogeneous environments requires a framework that assures careful balancing of fidelity to core functional elements with adaptations to ensure compatibility with new contexts.

Objective

This study aims to develop and apply a framework to guide tailoring and implementing CDS across diverse clinical settings.

Methods

In preparation for a multisite trial implementing CDS for pediatric overweight or obesity in primary care, we developed the User-Centered Framework for Implementation of Technology (UFIT), a framework that integrates principles from user-centered design (UCD), human factors/ergonomics theories, and implementation science to guide both CDS adaptation and tailoring of related implementation strategies. Our transdisciplinary study team conducted semistructured interviews with pediatric primary care clinicians and a diverse group of stakeholders from 3 health systems in the northeastern, midwestern, and southeastern United States to inform and apply the framework for our formative evaluation.

Results

We conducted 41 qualitative interviews with primary care clinicians (n=21) and other stakeholders (n=20). Our workflow analysis found 3 primary ways in which clinicians interact with the electronic health record during primary care well-child visits identifying opportunities for decision support. Additionally, we identified differences in practice patterns across contexts necessitating a multiprong design approach to support a variety of workflows, user needs, preferences, and implementation strategies.

Conclusions

UFIT integrates theories and guidance from UCD, human factors/ergonomics, and implementation science to promote fit with local contexts for optimal outcomes. The components of UFIT were used to guide the development of Improving Pediatric Obesity Practice Using Prompts, an integrated package comprising CDS for obesity or overweight treatment with tailored implementation strategies.

Trial Registration

ClinicalTrials.gov NCT05627011; https://clinicaltrials.gov/study/NCT05627011
U-Shaped Relationship Between Fibrinogen Level and 10-year Mortality in Patients With Acute Coronary Syndrome: Prospective Cohort Study
Authors: Li Yi ming , Jia Yuheng , Bai Lin , Yang Bosen , Chen Mao , Peng Yong
Published: May 2024

This study demonstrated that fibrinogen is an independent risk factor for 10-year mortality in patients with acute coronary syndrome (ACS), with a U-shaped nonlinear relationship observed between the two. These findings underscore the importance of monitoring fibrinogen levels and the consideration of long-term anti-inflammatory treatment in the clinical management of patients with ACS.
Gender Inequalities of Health and Quality of Life in Informal Caregivers in Spain: Protocol for the Longitudinal and Multicenter CUIDAR-SE Study
Authors: Garcia-Calvente María del Mar , Mora Diana Juanita , Del Río-Lozano María
Published: May 2024

Background

The aging population and increased disability prevalence in Spain have heightened the demand for long-term care. Informal caregiving, primarily performed by women, plays a crucial role in this scenario. This protocol outlines the CUIDAR-SE study, focusing on the gender-specific impact of informal caregiving on health and quality of life among caregivers in Andalusia and the Basque Country from 2013 to 2024.

Objective

This study aims to analyze the gender differences in health and quality of life indicators of informal caregivers residing in 2 Spanish autonomous communities (Granada, Andalusia, and Gipuzkoa; Basque Country) and their evolution over time, in relation to the characteristics of caregivers, the caregiving situation, and support received.

Methods

The CUIDAR-SE study uses a longitudinal, multicenter design across 3 phases, tracking health and quality of life indicators among informal caregivers. Using a questionnaire adapted to the Spanish context that uses validated scales and multilevel analysis, the research captures changes in caregivers’ experiences amid societal crises, notably the 2008 economic crisis and the COVID-19 pandemic. A multistage randomized cluster sampling technique is used to minimize study design effects.

Results

Funding for the CUIDAR-SE study was in 3 phases starting in January 2013, 2017, and 2021, spanning a 10-year period. Data collection commenced in 2013 and continued annually, except for 2016 and 2020 due to financial and pandemic-related challenges. As of March 2024, a total of 1294 participants have been enrolled, with data collection ongoing for 2023. Initial data analysis focused on gender disparities in caregiver health, quality of life, burden, perceived needs, and received support, with results from phase I published. Currently, analysis is ongoing for phases II and III, as well as longitudinal analysis across all phases.

Conclusions

This protocol aims to provide comprehensive insights into caregiving dynamics and caregivers’ experiences over time, as well as understand the role of caregiving on gender inequality in health, considering regional variations. Despite limitations in participant recruitment, focusing on registered caregivers, the study offers a detailed exploration of the health impacts of caregiving in Spain. The incorporation of a gender perspective and the examination of diverse contextual factors enrich the study’s depth, contributing significantly to the discourse on caregiving health complexities in Spain.

International Registered Report Identifier (IRRID)

DERR1-10.2196/58440