bluuebunny/crossref_metadata_2025 huggingface dataset:
PENDAMPINGAN PROGRAM DESA MAKMUR PEDULI API DALAM PENINGKATAN EKONOMI MASYARAKAT DAN KONSERVASI HUTAN OLEH SINARMAS FORESTRY DI REGION JAMBI
Authors: Nugroho Canggih Rizki , Sugihardjo Sugihardjo , Ihsaniyati Hanifah
Published: July 2020

This study aims to find out about the assistance of the DMPA program in improving community economy and conservation of forest resources by Sinarmas Forestry in Jambi Region. Using a qualitative method with the EMIC approach described in a natural manner about the DMPA program in Jambi Region. The location of the study was conducted in Dataran Kempas Village (District I) and Sungai Rotan Village (District VIII) Jambi Province. The location was chosen based on data from PT Wirakarya Sakti that the two villages are villages with the recipients of the best DMPA program with two different assistance in the Jambi region. The study was conducted in April - June 2018 with snowballselected informants including SCD Manager Assistant, Dataran Kempas Village Head, District Secretary and Assistants of Dataran Kempas and Sungai Rotan Villages, DMPA program managers (chairman / member of farmer groups) and chairman of BUMDes Dataran Kempas. Data collection is done by interviews (independent interviews), observation, focus group discussions, and documentation. Data were analyzed using interactive analysis models. Based on the aspects studied, the results obtained were that the mentoring of the DMPA program in the study location villages had a positive influence on the community in raising awareness of forest conservation, but it still had no impact on improving the economy of the recipient community.
SIKAP PETANI TERHADAP PROGRAM GELAR LAPANG INOVASI PERTANIAN (GLIP) BERBASIS PADI DI KECAMATAN GULUK-GULUK, KABUPATEN SUMENEP
Authors: Susanta Sonia Aprilia , Wibowo Agung , Widiyanti Emi
Published: July 2020

This research was aimed to investigate the attitudes of farmers toward Agricultural Innovation Field Organizing Program Based on Paddy, to study farmer’s attitude toward program, to study the factors that form the attitude of farmers toward the program, and analyzing the relationship between factors influencing farmer’s attitude toward program. The basic method was quantitative research with survey technique. Location of research was determined purposivelywhere is District Guluk-Guluk Sumenep Regency. The sample was determined by random sampling technique, who are 43 rice farmers participated in the Agricultural Innovation Field Organizing Program Based on Paddy for the August-November period. In determining respondent’s number from each farmer group, it used proportional random sampling. The data used that for analysiswere primary data and secondary data. Data was analyzed by Rank Spearman correlation coefficient (rs)to know the relation of factors that formed attitude with farmer’s attitude toward Agricultural Innovation Field Organizing Program Based on Paddy. The factors that formed the farmers’ attitude in Guluk-Guluk Sub-district of Sumenep Regency were personal experience in very high category, non-formal education in very high category, cultural role in high category, the role of others that are considered important in medium category, media exposure in low category, and extension roles in very high categories.Based on rank spearman (rs), showed thatthere was a significant relationship between personal experience, non-formal education, the role of culture, and the role of investigator with farmer’s attitudes toward the program, while the roles of others that were considered important and mass media exposure had no significant relationship with farmers' attitudes toward the program
PARTISIPASI MASYARAKAT DALAM PENGEMBANGAN KAWASAN AGROPOLITAN PROGRAM PADAT KARYA TUNAI DI DESA TASIKMADU KECAMATAN PALANG KABUPATEN TUBAN
Authors: Lestari Winda Ayuning , Lestari Eny , Rusdiyana Eksa
Published: July 2020

This research aims to analyze the level of community participation in the development of the agropolitan area Cash for Works Program, analyzing internal factors and external factors that influence community participation; and analyze the relationship between internal factors and external factors of participation with the level of community participation in the development of the agropolitan area Cash for Works Program in Tasikmadu Village, Palang District, Tuban Regency. This study uses quantitative methods with survey techniques. The research location is in Tasikmadu Village, Palang District, Tuban Regency because there is an agropolitan area of star fruit plantation. The sampling technique by multistage cluster random sampling was 69 respondents. Data analysis using Spearman Rank correlation test. The results of the study showed: (1) Age of the community included in the category of age 36-55 years, with an average level of education graduating from high school / equivalent, land ownership area ≤ 0.3 ha, income level of the agricultural sector>2.1 million, length live on average>21 years, with the level of cosmopolitan including very low category and stakeholders including quite active category. (2) The level of community participation is included in the category of moderate participation and is on the consultation ladder. (3) Spearman's Rank correlation test shows that internal and external factors that are significantly related to community participation are the extent of land ownership, income level and the level of cosmopolitan, while age, education level, length of stay, and stakeholders are not significantly related.
PARTISIPASI PETANI DALAM KEGIATAN PENINGKATAN PRODUKSI SAYURAN DAN TANAMAN OBAT MELALUI KAWASAN ANEKA CABAI DI KECAMATAN KISMANTORO KABUPATEN WONOGIRI
Authors: Prasetyo Nurhudha Agung , Lestari Eny , Ihsaniyati Hanifah
Published: July 2020

The aims of this research are to know the farmers’ internal factors related to farmer participation in activities to increase vegetable production and medicinal plants through various chili areas, analyze the level of farmer participation in activities to increase vegetable production and medicinal plants through various chili areas, and analyzing the relationship of farmers’ internal factors with the level of farmer participation in activities to increase vegetable production and medicinal plants through various chili areas. This research uses quantitative  methods  with  survey  techniques.  The research location was determined intentionally, namely Kismantoro Subdistrict, with the consideration that the sub-district was the district with the largest land area and production yield in Wonogiri Regency. The research population this time is farmers who are members of farmer groups that receive activities namely 197 farmers. The sampling method was carried out proportionally random sampling, with a sample size of 60 farmers. To test the relationship, rank spearman analysis was used with SPSS version 20. The results showed that the majority of farmers were of productive age, the most formal farmers were elementary school graduates, farmers in the low category, the largest farmer area was 0.51-0, 75 ha, the level of farmer risk taking in the high category, the activeness of farmer membership in the medium category. The level of farmer participation at the planning stage and at the implementation stage is classified as a moderate category, while the level of farmer participation at the utilization stage of the results is classified as high. The internal factors of the farmer who have a significant relationship with the level of farmer participation are age, non-formal education, risk-taking level and liveliness of farmer membership, while the farmers’ internal factors that have no relation to farmer participation level are formal education and land tenure.
PERSEPSI PETANI TERHADAP PROGRAM DEMONSTRASI AREA BUDIDAYA TANAMAN SEHAT PADI (STUDI KASUS DI KECAMATAN POLOKARTO KABUPATEN SUKOHARJO)
Authors: Ardhianta Luthfi Agung , Setyowati Retno , Wibowo Agung
Published: July 2020

The objectives of the study were to assess, the perception of farmers on the program for demonstration area of healthy rice cultivation, examine the characteristics of the factors forming the perception of farmers participating in the program for demonstration area of healthy rice cultivation, analyze of the correlation between the factors forming perceptions farmers to demonstration healthy rice cultivation area program. The study used the method of descriptive by using survey techniques. The location was in Polokarto, Sukoharjo, taking 2 villages implementing the program. The population was the member farmers of the Pilangrejo farmer group and the Kenteng Farmer Group. The study used a proportional random sampling technique and respondents were taken as many as 60 farmers. The data in this study were presented with a Likert scale and to test the correlation used Spearman rank analysis and t-test. The results showed that, the factors forming perceptions were age, formal education, non-formal education, land area, income, experience, and motivation,  Farmers’ perceptions of the understanding, goals, benefits, and activities contained in the program demonstration area of healthy rice crop cultivation were good, There was a significant correlation between income and experience of farmers to the program demonstration area of healthy rice cultivation. Whereas age, formal education, non-formal education, land area, and motivation were not significantly related to farmers’ perceptions of the program for the cultivation of healthy rice.
PARTISIPASI PETANI DALAM PROGRAM KLASTER PERTANIAN MODERN DI KECAMATAN TAWANGSARI, KABUPATEN SUKOHARJO
Authors: Adiarsi Atika , Anantanyu Sapja , Wijianto Arip
Published: July 2020

Farmers’participation is importantly studied to improve farmers’involvement of agricultural program. Objectives of this research were 1) to study about level of farmers’ participation of modern agricultural cluster program, 2) to study about factors which affected farmers’ participation, 3) to study about correlation between factors which affected the participation and level of farmers’participation. This research used quantitative method with technique of survey. The location that was chosen in Tawangsari district. The population of this research was farmers which were incorporated a combined farmers’ group, Tani Mandiri. This research used technique of proportional random sampling and the respondents were taken sixty farmers from each farmers’ group. The data on this research was shown with likert scale and testing the correlation used analysis of rank spearman. The result showed 1) farmers’ participation was included in high category. Planning, monitoring and evaluation and utilization of the result that included in high category, whereas for the implementation included in low category 2) the factors which consisted of education level and group communication’s behavior included in the lowest category. Number of family, cosmopolitan nature, time allocation, intensity of following the program socialization included in low category. Experience of farming business included in high category 3) the correlation test showed the factors which significantly related to farmers’ participation were education level, cosmopolitan nature, group communication’s behavior, and intensity of following the program socialization. The related factors which were not significant with farmers’participation were number of family, experience of farming business, and time allocation.

 
Independensi Media Massa Lokal Di Madura Selama Masa Kampanye Pemilihan Presiden 2019
Authors: Triandika Lulus Sugeng
Published: July 2020

Media massa memiliki peran penting selama masa kampanye Pemilihan Presiden dan Wakil Presiden. Sebagai alat komunikasi politik, media massa memiliki pengaruh kuat bagi publik. Fenomena tersebut menjadi komoditas pemberitaan pada media massa, baik lingkup nasional maupun daerah. Topik tentang pemilihan presiden menjadi tajuk berita utama di mayoritas media massa. Radar Madura, salah satu media cetak lokal di Madura, Bahkan beberapa kali menjadikan kampanye pemilihan presiden dan wakil presiden sebagai tajuk berita utama. Netralitas dan independensi media massa pada masa kampanye kemudian perlu dikaji kembali. Berdasarkan fakta bahwa redaksi media massa bisa menentukan sudut pemberitaannya. Maka perlu dikaji untuk mengetahui makna pembingkaian berita. Analisis framing dengan pendekatan teori milik Pan dan Kosicky digunakan untuk mengkajinya. Hasilnya adalah ditemukan fakta bahwa Radar Madura telah melakukan pembedaan tema dan konsep pemberitaan kampanye calon presiden dan wakil presiden. Fakta tersebut merupakan representasi kecondongan redaksi terhadap salah satu calon Presiden dan Wakil Presiden.
Analisis Semiotik Pesan Dakwah Dalam Film “Di Bawah Lindungan Ka’bah” Perspektif Roland Barthes
Authors: Zaini Ahmad
Published: July 2020

Tulisan ini bertujuanuntuk mengetahui lambang-lambang (signs) pesan dakwah yang dimunculkan dalam film Di Bawah Lindungan Ka’bah dan untuk mengetahui pesan-pesan dakwah yang terkandung dalam film Di Bawah Lindungan Ka’bah. Hasil penelitian menunjukkan bahwa film tersebut memuat masalah akidah, syariah dan akhlak. Materi akidah tercermin pada keimanan Hamid dan ibunya kepada Allah swt. yang sudah tertanam pada dirinya sejak kecil. Hamid mengatakan kepada ibunya bahwa dalam kehidupan ini janganlah mengukur segala sesuatu dengan yang kelihatan saja, karena pada dasarnya apa yang kelihatan berasal dari yang tidak terlihat. Dan yang tidak terlihat itu adalah Allah swt. Materi syariah (ibadah dan muamalah) tampak dalam ilustrasi Zainab yang sedang membaca al-Quran, Hamid, ibunya serta Zainab yang sedang salat dan ibadah haji yang diilustrasikan bahwa Hamid sedang melaksanakan rangkaian manasiknya. Sedang materi akhlak tampat ketika Hamid beserta ibunya mengucapkan salam saat berkunjung ke rumah Engku Ja’far dan Hamid yang sedang menolong seorang ibu yang jatuh barang bawaannya.
Masjid Sebagai Pusat Dakwah Islam di Kampung (Studi Masjid Darus Sa’adah Desa Hadipolo Kec. Jekulo Kab. Kudus)
Authors: Zaman Wahyu Khoiruz
Published: July 2020

Masjid menjadi salah satu simbol penting bagi agama Islam, baik sejak masa awal perjalanan dakwah Nabi Muhammad SAW maupun masa kini. Meskipun masjid menjadi simbol terpenting, namun pengelolaan dan karakter masjid memiliki gambaran yang berbeda-beda sesuai dengan kondisi dan situasi keberadaan masjid tanpa mengurangi fungi utama masjid sebagai tempat ibadah. Artikel ini mendiskripsikan tentang masjid Darus Sa’adah yang terletak di Desa Hadipolo Kecamatan Jekulo Kabupaten Kudus. Masjid tersebut memiliki karakter tersendiri yang tidak lepas dari perjalanan sejarah dan letak masjid yang berada di sebuah kampung di kota kretek. Selain sebagai tempat ibadah, masjid tersebut menjadi pusat dakwah bagi pendirinya yakni KH Zainal Khafidzin.
Keterampilan Berpikir (Mind Skills) Pada Proses Konseling: Kajian Dalam Perkembangan Kognitif Neurosains
Authors: Azmi Khilman Rofi
Published: July 2020

Perkembangan dalam keilmuan psikologi dan bimbingan konseling adalah indikator berkembangnya kajian keilmuan yang signifikan. Salah satu issue/ problem konselor terbesar adalah praktik konseling. Konseling sebagai “jantung” dari tugas dan tanggungjawab konselor memiliki tiga keterampilan dasar kebutuhan, yaitu keterampilan komunikasi, keterampilan bertindak, dan keterampilan berpikir. Keterampilan berpikir adalah proses mental sentral dengan enam aspek yang menciptakan: (1) aturan; (2) persepsi; (3) Self Talk; (4) gambar visual; (5) penjelasan; (6) harapan. Keterampilan berpikir dibuktikan oleh peneliti untuk meningkatkan kualitas konseling dan fokus untuk mengelola pikiran superconscious. Tulisan ini mencoba menghubungkan antara keterampilan berpikir dengan aktivitas otak dalam perspektif ilmu saraf. Proses keterampilan berpikir berhubungan dengan neuroscientific notions dari kontrol kognitif kemudian melewati sintesis di mana subfraksi kortikal prefrontal dorsolateral dan anterior berinteraksi dengan korteks interoceptive (cingulate dan insula) untuk meningkatkan kecakapan berpikir.   Artikel ini  menggunakan kajian studi literatur sebagai metode penelitian dengan mengeksplorasi dan mengkaji beberapa literatur: buku, jurnal, disertasi, e-book, dan beberapa kasus yang terjadi di masyarakat.

Kata kunci: keterampilan berpikir, cognitive neuroscience, development
Islam, Etika Dan Spiritualitas: Perannya Dalam Dunia Konseling Dan Keperawatan yang Multikultur
Authors: Isnawati Zakiyah , Nurhayati Sri
Published: July 2020

Dunia profesi keperawatan dan konseling merupakan kegiatan yang banyak menggunakan komunikasi dan tatap muka antar manusia. Objek dan subjek yang berkomunikasi bisa saja memiliki perbedaan –perbedaan yang mendasar seperti ras, budaya, agama, dan lain-lain. Dalam tulisan ini menekankan pada aspek spiritualitas dan etika, khususnya dalam ajaran agama Islam dalam memecahkan permasalahan multikultural dan perbedaan di dunia keperawatan dan konseling. Islam sebagai agama dengan pemeluk yang besar di dunia ini pastinya diikuti oleh tumbuhnya budaya di masing-masing wilayah. Tujuan tulisan ini adalah untuk menemunkan relevansi ajaran Islam dalam dunia keperawatan dan konseling, khususnya aspek spiritualitas dan etis.

Kata kunci: Islam, Keperawatan dan konseling, Spiritualitas, Etika, Multikultur
Kepribadiaan Konselor Dan Proses Konseling Melalui Pendekatan Kearifan Budaya Lokal Applekelebbireng Pada Masyarakat Bugis Bone
Authors: Nurmawati Nurmawati
Published: July 2020

Konselor profesional merupakan figur yang dapat menampilkan dirinya sebagai teladan. Di antara kompetensi konselor, yang paling penting adalah kualitas pribadi konselor karena konselor sebagai pribadi harus mampu menampilkan jati diri secara utuh, tepat, dan berarti, serta membangun hubungan interpersonal yang baik sehingga menjadi motor penggerak keberhasilan layanan. Pribadi konselor merupakan ‘instrumen’ yang menentukan hasil positif dalam proses konseling, sebab inti dari proses terapeutik dalam konseling yaitu hubungan yang dibangun antara konselor dan konseli, sehingga kualitas pribadi konselor merupakan hal yang esensial bagi konselor untuk mencapai tujuan dalam proses konseling. Proses konseling tidak terlepas dari etnis budaya salah-satunya adalah budaya masyarakat Bugis Bone mappakalebbi sesama manusia dengan mendahulukan nilai-nilai appekelebbireng lempu’, macca, mappassalama’, Siri’. Nilai-nilai inilah yang harus diterapkan dalam proses konseling Bugis Bone dengan melihat kepribadian konselor dengan bertutur kata, cara berprilaku (Mappatabe’, Berdiri jika ada tamu yang berkunjung, posisi duduk dan tidak memanggil orang tua dengan namanya).

Kata Kunci : Pribadi Konselor, Konseling, Appakalebbireng.
Cross Cultural and Cultural Counseling: Komunikasi Konseling Lintas Budaya Jawa dan Madura di Madrasah Aliyah Negeri 1 Jember
Authors: Suryadi Suryadi
Published: July 2020

Penelitian ini bertujuan untuk menemukan model komunikasi efektif antara peserta didik yang berlatar belakang budaya Madura dengan peserta didik yang berlatar belakang budaya jawa. Penelitian ini menggunakan metodologi kualitatif dengan menyusun, memahami dan menganalisis model komunikasi peserta didik yang berlatar belakang budaya Madura dengan peserta didik yang berlatar belakang budaya jawa di Madrasah Aliyan Negeri (MAN) 1 Jember. Model komunikasi peserta didik dari budaya Madura dengan Jawa dipengaruhi oleh kultur bahasa dari atmosfer lingkungan yang berbeda. Dari sini terlihat bagaimana proses layanan konseling yang inklusif dan ramah berjalan melalui pendekatan transcultural menjadi langkah yang dilakukan oleh guru BK atau konselor Madrasah guna meminimalisir adanya gesekan sosila yang pernah terjadi pada peserta didik beretnis Jawa dengan peserta didik beretnis Madura.

Kata Kunci: Cross Cultural, Cultural Counseling, Komunikasi, Lintas Budaya, Siswa, Madrasah

 
Intervensi Program Bimbingan dan Konseling dalam Mengatasi Bullying Siswa Madrasah Aliyah Negeri Salatiga
Authors: Nurlatifah Andar Ifazatul
Published: July 2020

The Intervention Of Guidance And Counseling Program to Overcome The Bullying Of MAN Salatiga Students. This article a mixed method research with concurrent triangulation design to examine (1) the phenomenon of bullying at MAN Salatiga, (2) the guidance and counseling intervention to deal with bullying at MAN Salatiga, and (3) the ideal guidance and counseling program to overcome bullying at MAN Salatiga. Scale delivered to 157 respondents to measure students’ understanding and involvement in bullying. Interviews with students, guidance and counseling teachers, and FGD followed by lecturers and counselors used to collect information about bullying and bullying intervention. The results of the study revealed that students’ understanding of the concept of bullying is 73.41%, 44.76% students involved in bullying as witness; 34.13% as victim; and 34.25% as bully. There are differences between men and women in understanding of bullying concept and the involvement in bullying. The guidance and counseling teachers’ interventions in dealing with bullying are focused on guidance and counseling responsive services in the form of curative efforts to the victim and bully. Therefore, the ideal program in dealing with bullying is carried out evenly in the frame of guidance and counseling basic services, responsive services, individual planning services, and system support to the victim, the bully, and the witness.
MENYOAL KEWENANGAN PENGADILAN NEGERI DALAM MENYELESAIKAN PERKARA WARIS MASYARAKAT MUSLIM PASCA LAHIRNYA UNDANGUNDANG NO. 3 TAHUN 2006 TENTANG PERADILAN AGAMA (Studi Kasus di Kabupaten Jombang Jawa Timur)
Authors: Tohari Ilham
Published: July 2020

The title of this article is: Questioning the Authority of the
District Court in Resolving Inheritance Cases of Muslim
Community after The Enactment of Law No. 3 Year 2006 on the
Religious Court (A Case Study in Jombang District Court, East
Java). The focus of this article includes (1) The reasons Jombang
Muslim community chose the District Court in resolving their
inheritance case; (2) The reasons the District Court receive,
examine and make decisions on inheritance case of Muslim Society.
These points are analyzed descriptively, qualitatively, and
phenomenologically, using the approach of law sociology and law
politics.
MODERASI PEMIKIRAN HUKUM ISLAM IMAM SYAFI’I
Authors: Naim Abdul Haris
Published: July 2020

Almost every life is always characterized by motion and dynamics.
Starting from the movement and dynamics of change and
development of thought with a variety of variants, always occur
continuously without knowing the limits. Likewise in religion, the
existence of a religion will be judged to have a function for a life, if
religion in practice opens a wide space for the demands of motion
and the dynamics of life as intended. The same thing happens also
in Islam, on the one hand it is considered a value system that is
able to provide guidance and direction for human life, but on the
other hand it requires dynamic space constructed from the basics
of norms that have the essence of universal truth, because in life
always requires constant movement and change from situation to
situation and from conditions to other conditions.
 
EFEKTIVITAS SISTEM INFORMASI MANAJEMEN NIKAH (SIMKAH) DALAM IMPLEMENTASI UNDANG-UNDANG NOMOR 24 TAHUN 2013 DI KUA KECAMATAN MEJOBO KUDUS
Authors: Riyadi Fuad
Published: July 2020

Manajeman Marriage Information System (SIMKAH) is a aplication
progam based on windows computer that is useful for collecting
marriage data from all Religious Affairs Offices (KUA) in the Republic
of Indonesia online and offline, the data will be stored safely at the
local KUA, in the Regency in Provincial Regional Offices and in
Islamic Community Development. These data are useful for making
various analyzes and reports according to various needs. The SIMKAH
aims to help implement Law no 24 of 2013 Concerning Amendments to
Law no 23 of 2006 Concerning Population Administration. Although
this effort has not gone well
Las redes sociales como fuentes de información para ampliar la agenda temática de los cibermedios
Authors:   Universidad del País Vasco, Argiñano José Luis
Published: July 2020

Las redes sociales son un caladero de información de fácil acceso. Este trabajo examina el impacto de las redes sociales en el contenido y en las fuentes de información de 20 Minutos, el primer diario en España que acometió la fusión de la redacción de papel y sweb. Se trata de conocer si la información que extrae de Facebokk o Twitter se diferencia de la obtenida en los caladeros clásico y si, por consiguiente, ha servido para ensanchar la agenda mediática en las versiones online. La metodología elegida es la entrevista en profundidad a siete profesionales de 20 Minutos, incluido su fundador y director Arsenio Escolar. Las primeras conclusiones apuntan a que las redes proporcionan una más fácil interacción con los lectores que redunda en una mayor presencia de voces sociales en los medios, pero su efecto no es la inclusión de temas de alto valor informativo sino una mayor espectacularización del contenido periodístico. Por el contrario, las instituciones conocen y manejan las redes para poner en bandeja a los medios contenidos que terminan por homogeneizar el mensaje de los cibermedios, incluido un producto concebido genuino como 20 Minutos.
Tiempo y Medio Ambiente como ejes noticiosos en los informativos de TVE, Antena 3 y Telecinco
Authors:   Universidad de Sevilla, Alonso González Marián
Published: July 2020

Si hasta hace apenas una década, el tiempo y la previsión meteorológica ocupaban un espacio propio al final de los informativos, desde hace unos años forman parte indiscutible del conjunto de las informaciones diarias, llegando a tener un lugar destacado cuando adquiere dimensiones de catástrofes y desastres naturales. Inundaciones, olas de calor o temporales de viento y lluvia son causas evidentes del cambio climático, uno de los mayores motivos de preocupación para los españoles, por delante, incluso, de los conflictos armados. El presente estudio cuantifica el peso específico que este tipo de información posee dentro de los informativos televisivos de TVE1, Antena 3 y Telecinco, en su franja de mediodía, poniendo de manifiesto la importancia que las tres cadenas otorgan a este tipo de noticias, sobre todo en su vertiente amarillista y catastrofista, aunque, bien es cierto, que se aprecia una incipiente, y aún débil tendencia, a transmitir estas noticias desde un punto de vista pedagógico que permita concienciar a los españoles en la necesidad de tomar medidas para paliar las consecuencias del cambio climático
Leaf to panicle ratio (LPR): a new physiological trait indicative of source and sink relation in japonica rice based on deep learning
Authors: Yang Zongfeng , Gao Shang , Xiao Feng , Li Ganghua , Ding Yangfeng , Guo Qinghua , Paul Matthew J. , Liu Zhenghui
Published: July 2020

Background : Identification and characterization of new traits with a sound physiological foundation is essential for crop breeding and management. Deep learning has been widely used in image data analysis to explore spatial and temporal information on crop growth and development, thus strengthening the power of the identification of physiological traits. This study aims to develop a novel trait that indicates source and sink relation in japonica rice based on deep learning.Results : We applied a deep learning approach to accurately segment leaf and panicle and subsequently developed the procedure of GvCrop to calculate the leaf to panicle ratio (LPR) of rice populations during grain filling. Images of the training dataset were captured in the field experiments, with large variations in camera shooting angle, the elevation angle and the azimuth angle of the sun, rice genotype, and plant phenological stages. Accurately labeled by manually annotating all the panicle and leaf regions, the resulting dataset were used to train FPN-Mask (Feature Pyramid Network Mask) models, consisting of a backbone network and a task-specific sub-network. The model with the highest accuracy is then selected to study the variations in LPR among 192 rice germplasms and among agronomical practices. Despite the challenging field conditions, FPN-Mask models achieved a high detection accuracy, with Pixel Accuracy being 0.99 for panicles and 0.98 for leaves. The calculated LPRs showed large spatial and temporal variations as well as genotypic differences.Conclusion : Deep learning techniques can achieve high accuracy in simultaneously detecting panicle and leaf data from complex rice field images. The proposed FPN-Mask model is applicable for detecting and quantifying crop performance under field conditions. The newly identified trait of LPR should provide a high throughput protocol for breeders to select superior rice cultivars as well as for agronomists to precisely manage field crops that have a good balance of source and sink.
Effective treatment with tacrolimus for patients with non-severe aplastic anemia refractory/ intolerant to cyclosporine A: a retrospective study
Authors: Du Yali , Huang Yuzhou , Zhou Wenzhe , Liu Xinjian , Chen Fangfei , Yang Chen , Chen Miao , Ruan Jing , Han Bing
Published: July 2020

Background: For the symptomatic non-severe aplastic anemia (NSAA) patients who cannot afford anti-thymocyte globulin (ATG) or allogeneic hematopoietic stem cell transplantation (HSCT), tacrolimus (FK) was occasionally reported to be an option if they were not response or tolerant to the cyclosporine A (CsA). Method: We collected and analyzed respectively 101 NSAA patients refractory or intolerant to CsA with no chance of HSCT or ATG, and treated them with tacrolimus for at least 6 months and followed up for at least one year. Results: The overall response (ORR) was 38.6% (complete response: 9.9%; partial response: 28.7%) and the median time to optimal response was 6 (3～10) months. 32 (31.7%) cases had elevated creatinine level. 8 (7.9%) cases had elevation of AST/ALT. 25.6% (10/39) of patients relapsed at the end of follow-up. Age (P=0.0005), FK concentration (4.0~12ng/ml, P=0.0005) and intolerance to CsA (P=0.012) were the independent risk factors for ORR. Treg cells level pre-FK treatment was much lower than healthy controls (3.7±0.6% vs 6.8±0.7%, P=0.0004), but increased significantly after FK treatment (3.7±0.6% vs. 7.1±0.8%, P=0.0039). Conclusion: Our data provide a possibility of tacrolimus as a salvage treatment for patients with NSAA refractory or intolerant to CsA.
Efficacy and safety of novel treatments in chemotherapy-naïve castration-resistant prostate cancer
Authors: Min ZhiChao
Published: July 2020

Background: Currently, novel treatment methods for chemotherapy-naïve castration-resistant prostate cancer (CRPC) patients have been applied in clinical practice. Since the optimum regimen remains inconclusive, this study compares the efficacy and safety of these treatments by network meta-analysis. Methods: The PubMed and ClinicalTrials.gov database and review articles before January 30, 2020 were searched and date were extracted. A total of 29908 patients with CRPC from 23 randomized controlled trials were included. Relative hazard ratios (HR) had been used to assess the effects on overall survival (OS), progression-free survival (PFS) or radiographic PFS (rPFS), and adverse events (AEs). We then pooled the data and used Bayesian and frequentist random-effects model to identify the best treatment strategy. Results: Compared with the placebo, both Bayesian and frequentist random-effects network meta-analyses found that only enzalutamide and abiraterone had a significant effect in OS. Similar results were observed in PFS/rPFS. Bicalutamide, tasquinimod and orteronel could also improve rPFS. Enzalutamide only could improve rPFS more effectively than abiraterone with no significant differences in OS/PFS/AEs. In any subgroups of patients with age <75, ≥75 or ECOG score = 0,1 or Gleason score ≤7, ≥8, enzalutamide could improve the OS significantly. Nevertheless, the significant benefit of abiraterone was only found in patients with age <75 and ECOG score = 0.Conclusions: Our network analysis suggested that both enzalutamide and abiraterone are optimal treatment for chemotherapy-naïve CRPC patients with age <75 and ECOG score = 0 for great improvement on OS and PFS. In addition, enzalutamide is also an optimum therapy for chemotherapy-naïve CRPC patients with age ≥75 and ECOG score = 1.
Cost of Implementing Complex Community Intervention for Healthier Lifestyle at Five Health Clinics in Malaysia
Authors: HALIM NUR HIDAYATI ABDUL , Bakar Nurul Salwana Abu , Zainuddin Nur Azmiah
Published: July 2020

BackgroundA complex community intervention for behavioural change through the use of behaviour change counselling provided by community health promoters (CHPs) and utilisation of an E-health platform was designed to address an increasing number of obese and overweight women entering pregnancy. This paper describes a cost analysis of this novel intervention.MethodsThe analysis was performed from a provider’s perspective, and calculated in Malaysian ringgit (RM). Included were costs for purchase of clients’ progress monitoring equipment, including anthropometric measurement and information technology (IT) equipment; training and education of the CHPs and other healthcare personnel; and cost of contact between the clients and the providers; excluding costs for intervention planning and resource development; and research costs.ResultsAssuming that the intervention is running at a steady state; utilising existing facilities; and does not require additional time; total cost was RM 445,725.51 and average cost per intervention per person RM 3,073.97. About 50% of the total cost was for the purchase of IT equipment, 17% for the maintenance of the system and the remainder for consumables, emoluments and utilities.ConclusionsFindings of this study suggests that implementation of the intervention requires the provider to invest heavily in IT hardware and maintenance of the E-health platform. However, this analysis is likely an under-estimate of the actual cost as it was conducted from a provider’s perspective only and the intervention was assumed to have matured and running at a steady state; which may not be the case as changes were undertaken during its implementation to allow for maximum outcome.Trial registration number: NMRR-15-2333-28679Date of registration: 22 March 2016
Clinical Severity and CT Features of the COVID-19 Pneumonia: Focus on CT Score and Laboratory Parameters
Authors: Duan Jianghui , Su Kunsong , Sun Hongliang , Xu Yanyan , Liu Liangying
Published: July 2020

Background: Although CT characteristics of Coronavirus Disease 2019 (COVID-19) pneumonia between patients with mild and severe forms of the disease have already been reported in the literature, there was little attention to the correlation of imaging features and laboratory testing. We aimed to compare the laboratory and chest CT imaging features in patients with COVID-19 pneumonia between non-severe cases and severe cases, and to analyze the correlation of CT score and laboratory testing.Methods: This study consecutively included 54 patients with COVID-19 pneumonia (26 males and 28 females, 26 to 92 years of age, 43 cases with non-severe and 11 cases with severe group). Clinical, laboratory and image data were collected between two subgroups. A CT score system was used to evaluate the extent of disease. Correlation between the CT score and laboratory data were estimated. Receiver operating characteristic (ROC) analysis was used to evaluate the diagnostic performance of CT score and laboratory tests.Results: Compared with non-severe patients, severe patients had showed increased white blood cell count, neutrophil count, neutrophil percentage, the neutrophil-to-lymphocyte ratio (NLR) and decreased lymphocyte percentage (all p < 0.05). Architectural distortion, pleural effusion, air bronchogram and consolidation-dominant pattern were more common in the severe group (all p < 0.05). CT score of the severe group was higher than the non-severe group (p < 0.001). For distribution characters of the lesions, diffuse pattern in the transverse distribution was more often seen in the severe group (p < 0.001). CT score was positively correlated with the white blood cell counts, neutrophil counts, the percent of neutrophil, NLR, alanine aminotransferase, lactate dehydrogenase and C-reactive protein, and was inversely related to the lymphocyte, the percent of lymphocyte. ROC analysis showed that when the optimal threshold of CT score was 13, the area under the curve was the largest, which was 0.855, and the sensitivity and specificity were 100% and 60% respectively for the diagnosis of the severe patients.Conclusion: CT score showed significant correlations with laboratory inflammatory markers, suggesting that chest CT and laboratory examination maybe provide a better reference for clinicians to judge the severity of diseases.
Analysis of the Histological Effect of the Shock Waves on the Integrated Musculature of the Quadriceps of Wistar Rats
Authors: Almeida Rodrigo Santos , Ferreira Raquel Ida , Galdino Daniel Antero de Almeida , Mariano Ítalo Guilherme Giarola de Freitas , Silveira Newton Fonseca da , Andrade Marco Antônio Percope de
Published: July 2020

Objective: Shock waves are high-energy, high-pressure mechanical sound pulses used in medicine since 1980 with lithotripsy in urolithiasis. In addition, studies have demonstrated the osteogenic effect of shock waves indicating their use in skeletal diseases. Although several articles describe the benefits of shock waves in muscle diseases, assessments of its histological effect on the process of cell regeneration are lacking. Therefore, the objetive of this study is evaluate the histological effect of extracorporeal shock wave therapy on the intact musculature of Wistar rats. Materials and Methods: Twelve Wistar rats, with a mean age of 8 weeks, were studied for a period of 21 days. The quadriceps muscle of the right paws was submitted to 3 sessions of extracorporeal shock wave therapy at weekly intervals. The left legs were used as a control. Subsequently, the animals were euthanized and the quadriceps muscles were biopsied for histological study using histological slides stained in hematoxylin-eosin and Gomori's trichomium. Muscle fiber size, morphology and number of nuclei, existence of inflammatory infiltration, satellite cell count, and number of vessels were evaluated. Statistical calculations were performed using software R version 3.5.2 using non-parametric methods. Continuous variables relating to the legs of the same animal were compared using the Wilcoxon paired test (signed-rank). Discrete variables were compared using Fisher's exact test with mid-p correction. Results were considered statistically significant when p <0.05. Result: In the musculature of the right paws, there was an increase in fibrovascular and satellite cells proliferation with a statistically significant difference (p <0.005). Conclusion: The demonstration of the angiogenic power and the proliferation of satellite cells induced by extracorporeal shock waves, it is possible to affirm that this constitutes promising therapy for several muscle injuries. The acceleration of muscle recovery in athletes stands out as a example, by minimizing the impact on the competitor's performance, reducing muscle pain and spasticity, and improving muscle strength in tendinopathies.
Salvianolic acid B ameliorates hepatocyte lipid droplet accumulation via stimulation of autophagy
Authors: Shi Yanan , Yuan Jihong , Yan Lihui , Liu Yajin , Pan Da , Mu Biao
Published: July 2020

Salvianolic acid B (Sal B) the most abundant bioactive member in Salvia miltiorrhiza and has been reported lots of benefits on the treatment of cardio-cerebral vascular diseases and metabolic diseases. Lipid droplets are dynamic organelles, excessive lipid droplets accumulation in liver caused fatty liver disease. In this study, we are interested in the effect of Sal B on hepatic lipid accumulation and its possible mechanism. We found Sal B treatment significantly decreased lipid accumulation and TG level in primary hepatocytes. Meanwhile, we discovered Sal B significantly stimulated hepatic autophagy. Then we used autophagy inhibitor 3-MA and reveled that Sal B showed little effect on improving hepatic lipid accumulation when autophagy was inhibited, which indicated Sal B reduced cellular lipid accumulation through activating autophagy. This study demonstrates Sal B ameliorate hepatic lipid accumulation through activation of autophagy. These findings contribute to its benefit on liver disease related to hepatic lipid accumulation and hepatic autophagy.
XAGE-1b Promotes the Proliferation, Invasion and Metastasis of Gastric Cancer
Authors: Men Hui , Zhang Zhi-wei , Lu Gui-feng , Tan Shun , Hu Wen-Hui , Yang Xin , Geng Fei
Published: July 2020

Background X antigen family member 1B (XAGE-1b), a member of XAGE subfamily and GAGE family, is upregulated in some malignant tumors and has been associated with the proliferation, invasion and metastasis of tumors. However, the biological roles of XAGE-1b in gastric cancer (GC) still remain unclear. Methods We detected the expression of XAGE-1b in 60 paired fresh tissues of GC patients by real-time RT-PCR. Kaplan-Meier survival curve was explored to analyze 5-year survival time of GC patients. Function experiments were performed to estimate the role of XAGE-1b on the proliferation, invasion and metastasis of GC cells. Informatic analysis was applied to investigate the potential mechanisms. Results XAGE-1b was obviously upregulated in GC tissues. XAGE-1b was correlated significantly with poor prognosis of GC patients. XAGE-1b markedly promoted the proliferation and invasion in GC cell lines in vitro. Knockdown of XAGE-1b promoted the pulmonary metastatic ability in nude mice. Moreover, XAGE-1b was positively or negatively correlated with the expression of CLDN6 and CHGA, which regulated the progression of GC. Conclusions XAGE-1b could act as an oncogene in GC, which provides a potential biological marker or treatment target for GC.
RetroSPECT: Gallium-67 As A Theranostic Imaging Agent
Authors: Bailey Dale L , Sabanathan Dhanusha , Aslani Alireza , Campbell Douglas H. , Walsh Bradley J. , Lengkeek Nigel A.
Published: July 2020

Gallium-67 has been in use in nuclear medicine for over 50 years. However, the tremendous interest in gallium imaging in theranostics in recent times has focused on the PET radionuclide gallium-68. In this article it is suggested that the longer-lived gallium-67, which has desirable characteristics for imaging with the gamma camera and a suitably long half-life to match biological timescales for drug uptake and turnover, has been overlooked, in particular, for treatment planning with radionuclide therapy. Gallium-67 could also allow non-PET facilities to participate in theranostic imaging prior to treatment or for monitoring response after therapy. Gallium-67 could play a niche role in the future development of personalised medicine with theranostics.
Mechanism underlying the role of Miaoyao Fanggan sachet in up-regulating respiratory tract immunity through TLR-MyD88-NFκB signaling pathway
Authors: Zhu Mingjie , Jia Guoquan , Zhang Quan , Li Guojun , Li Hong , Zhang Xiaofen , Li Lijun , Zhang Baofang , Xin Changqin , Cheng Mingliang
Published: July 2020

Background To elucidate the mechanism underlying the role of Miaoyao Fanggan sachet (MFS) in improving respiratory immunity through the TLR-MyD88-NFκB signaling pathway in MyD88 knockout mouse models and human normal lung epithelial cell line (BEAS-2B).Methods Sixteen male C57BL/6J mice (SPF grade) were randomly divided into the control (n = 8) and MFS groups (n = 8) and 16 male MyD88 knockout mice were randomly assigned into the MyD88 knockout (MyD88-KO group, n = 8) and MyD88 KO + MFS groups (n = 8). Mice in the MFS intervention group were continuously treated with MFS inhalation from 8:00 am to 8:00 pm for 30 d and the sachets were replaced every 6 d. Hematoxylin-eosin (H.E.) staining was used to observe the pathological changes of lung tissues. The expression levels of TAK1, NFκB p65, IκB and IL6 in mouse lung tissues were detected by immunohistochemical staining, immunofluorescent staining, Western blot and qRT-PCR, respectively.Results Mikawa’s lung injury score did not significantly differ between the control and MFS groups (both P > 0.05). The parameters related to liver and kidney function did not significantly differ among four groups (all P > 0.05). The TAK1, NFκB p65, IκB and IL6 mRNA and protein in the MFS group were significantly up-regulated than those in the other groups (all P < 0.05). Compared with the MyD88-KO group, they were significantly up-regulated in the MyD88-KO + MFS group (P < 0.05).Conclusion HFS can improve the respiratory immunity probably by up-regulating the expression level of MyD88, activating the TLR-MyD88-NFκB signaling pathway and stimulating the release of cytokines in the downstream pathway.
Formononetin Suppresses Interleukin-6 Production in Lipopolysaccharide-Stimulated Macrophages Via Activation of the AMP-Activated Protein Kinase
Authors: Zhang Lanfang , Zhang Xiaoyan , Wang Liying , Yang Wanxia , Qiao Yuanbiao , Li Qingshan
Published: July 2020

Background: Interleukin-6 (IL-6), an inflammatory cytokine, plays a majoy role in the pathogenesis of inflammation and serves as a key marker in the diagnosis and treatment of inflammation and related diseases. Formononetin (FMN), an isoflavone ingredient in various Chinese herbal medicines, inhibits the production of IL-6 in some cells. However, its mechanism of action has not been clearly established. In this study, we aimed to identify whether FMN inhibits IL-6 production in Lipopolysaccharide (LPS)-stimulated macrophages via AMPK activation.Methods: In the current study, the anti-IL-6 mechanism of FMN was evaluated using a macrophage model with LPS stimulation. An inverted microscope was utilized to obtain images of cells. Nuclear staining assay and CCK-8 assay were used to identify the viability of ANA-1 cells. The expression of IL-6 in cells was investigated by Enzyme-linked immunosorbent (ELISA) and Western blotting. The expression of AMP-activated protein kinase (AMPK) was determined by Western blotting and phosphorylation of AMPK was determined by Western blotting and Immunofluorescence assay. Bioinformatic analysis was used to predict potential targets of FMN. Results: we found that FMN reduced the expression of IL-6 in ANA-1 cells and increased the phosphorylation of AMPK. The effect of FMN was similar to that of acadesine, an AMPK activator, which also reduced IL-6 expression in LPS-induced ANA-1 cells and increased AMPK phosphorylation. Its combination with dorsomorphin (an AMPK inhibitor), however, reversed the effects of FMN on AMPK phosphorylation and IL-6 expression. The target of FMN was identified as the cAMP-dependent protein kinase inhibitor alpha, as searched in Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform and further verified with the STRING database. Conclusions: In conclusion, our findings suggest that FMN effectively inhibits IL-6 production by activating AMPK in LPS-stimulated macrophages.