bluuebunny/crossref_metadata_2025 huggingface dataset:
Ten Years' Experience with Free Tissue Grafts for Glottic Reconstruction
Authors: Quinn Harold J.
Published: April 2016

Thirty‐three cases of glottic reconstruction are presented. Free autogenous tissue transplants were used to reconstruct a pseudocord after extended frontolateral partial laryngectomy in which one arytenoid was excised. The observation period varied from 2 to 12 years. In 30 patients the reconstruction technique employed an autogenous free muscle transplant sutured into the endolaryngeal recipient muscle bed remaining after hemilaryngectomy. In three patients, free autogenous epiglottis was used instead of muscle. In every case the pseudocord tissue transplant was completely covered with advancement flaps of pyriform sinus mucosa. We believe this experience justifies the use of free autogenous tissue transplants into the endolarynx without fear of slough. Transplant shrinkage is fairly predictable and averages about one fourth of the original bulk of the implanted graft. Free tissue grafts for endolaryngeal reconstruction appear to possess the following advantages over extralaryngeal pedicles: (1) easy “tailoring” of the transplant; (2) easy positioning of the transplant directly opposite the retained functioning cord; (3) easy placement in the posterior commissure defect; (4) complete endolaryngeal relining by hypopharyngeal mucosa; (5) avoidance of stents or keels; (6) lack of distortion of extrinsic laryngeal motion and laryngeal tilt, which can be observed after pedicles are swung into the residual hemilarynx; (7) absence of contraction‐retraction vectors associated with various extralaryngeal pedicles which can distort extrinsic laryngeal motion; (8) assurance of complete “air‐tight” closure of the residual organ when pedicles are not placed into it.
Immunovirologic Assessment of American Patients with Nasopharyngeal Carcinoma and Occult Primary Tumors
Authors: Coates Harvey L. , Neel H. Bryan , Pearson Gary R.
Published: April 2016

The Epstein‐Barr virus (EBV) is closely associated with nasopharyngeal carcinoma, suggesting an etiologic relationship. We have undertaken studies (1) to quantitate the relationship between antibody titers to EBV‐associated antigens and nasopharyngeal carcinoma in American patients since most of the patients in previous studies were of either Asian or African descent and (2) to determine the relationship between antibody titers and the clinical course of disease. Sera from patients with primary or recurrent nasopharyngeal carcinoma and from patients in remission, from patients with various other head and neck tumors (including occult primary lesions and lymphomas), and from normal controls were titrated for IgG antibodies to viral capsid antigen (VCA) and early antigen and IgA antibodies to VCA, using indirect immunofluorescence procedures previously detailed. High titers of antibodies to EBV‐induced early antigen and VCA in the IgG fraction and VCA in the IgA fraction were frequently found in the sera of patients with nasopharyngeal carcinoma. A significant reduction in these titers was observed with clinical remission of the disease in treated patients. Preliminary findings suggest that EBV serology may be useful in the evaluation and treatment of patients with nasopharyngeal carcinoma and also in patients with cervical metastases from clinically occult primary sites in order to identify those with occult nasopharyngeal carcinoma.
Local Anesthesia in Facial Plastic Surgery
Authors: Dicker Ralph L. , Syracuse Victor R.
Published: April 2016

Although local anesthesia is ideal (or cosmetic facial surgery, it must be prepared and administered with at least as much care and attention to detail as with general anesthesia. Relegating the responsibility to ancillary help in both hospital and office operating rooms adds to the legal jeopardy to which the surgeon is exposed. The choice and dosage of local anesthetics and safety measures to be followed in their usage are discussed.
Eustachian Tube Bypass: Experimental Evidence for Total Eustachian Tube Substitution
Authors: Lapidot Abraham , Terrefe Dessaglegn , Rezvani Firooz , Hough Aubrey J.
Published: April 2016

Several preliminary reports have appeared in the medical literature in respect to eustachian tube substitution1–6 since Zollner7 first described his inability to open the obstructed eustachian tube. These procedures3,5,6 have the disadvantage that the distal end of the eustachian tube substitute is inaccessible by other than another operation.

This paper is a follow‐up report to our clinical experience.2 The purpose of the experiment was to determine whether the middle ear was ventilated by the tympano‐oropharyngeal substitute eustachian tube and whether ascending infection occurred.

Fourteen ears underwent eustachian tube substitution. The natural eustachian tubes of these ears were obliterated three to five months after eustachian tube substitution had been performed. The animals were killed three to four months after obliteration of the natural eustachian tubes. Studies of the decalcified sections showed an absence of infection in six of the ears, with mild to severe inflammation in the rest of the specimens.
Aspiration Cytology for Diagnosis of Head and Neck Masses
Authors: Meyers David S. , Templer Jerry , Davis William E. , Balch James A.
Published: April 2016

Most American clinicians have been reluctant to utilize aspiration biopsy due to poor interpretive skills by the pathologists in the past and a fear of tumor spread by the needle. Voluminous European series and recent American series have proved aspiration to be safe and reliable. In our series of 78 cases, both thin‐needle aspiration and conventional tissue biopsies were made. The diagnoses were compared and the overall agreement rate was 90%.
The use of diagnostic testing in asymmetric sensorineural hearing loss
Authors: Hendrix Robert A. , Dedio Robert M. , Sclafani Anthony P.
Published: April 2016

The etiology of an asymmetric sensorineural hearing loss can often be difficult to determine. Because a wide variety of pathologic processes may be responsible for the hearing loss, numerous diagnostic tests are usually used in the initial evaluation, including pure‐tone audiometry, acoustic reflex testing, imaging, serologic testing, and auditory brainstem response testing. The diagnostic evaluations of 225 consecutive cases of asymmetric sensorineural hearing loss are reviewed. A cochlear slte‐of‐lesion was demonstrated in the majority (194) of patients. Because all retrocochlear lesions (31) were associated with an abnormal auditory brainstem response, imaging should be performed in that group of patients. Magnetic resonance imaging offers greater specificity than computed tomography. Reflex decay, acoustic reflex testing, and rollover were all associated with a high false‐negative rate. Whereas serologic testing for syphilis yielded several cases of otosyphilis, thyroid function testing was of little value. A diagnostic protocol for asymmetric sensorineural hearing loss is presented.
The difficult dilation: A method for dilation of severe esophageal strictures in children
Authors: Gianoli Gerald J. , Guarisco J. Lindhe , Falterman Kenneth W.
Published: April 2016

Occasionally severe esophageal strictures will develop in children that will not allow the passage of standard Jackson or bougie dilators. These small strictures can be successfully treated using a standard intubating laryngoscope for visualization and Rush urethral Filiform dilators.
Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6
Authors: Uras Iris Z. , Walter Gina J. , Scheicher Ruth , Bellutti Florian , Prchal-Murphy Michaela , Tigan Anca S. , Valent Peter , Heidel Florian H. , Kubicek Stefan , Scholl Claudia , Fröhling Stefan , Sexl Veronika
Published: April 2016

Key Points

CDK6 directly regulates transcription of FLT3 and PIM1 in a kinase-dependent manner. CDK6 kinase inhibition impairs not only FLT3-dependent cell growth in vitro but also FLT3-driven leukemogenesis in vivo.
Histone Deacetylase 6–Controlled Hsp90 Acetylation Significantly Alters Mineralocorticoid Receptor Subcellular Dynamics But Not its Transcriptional Activity
Authors: Jiménez-Canino Rubén , Lorenzo-Díaz Fabián , Jaisser Frederic , Farman Nicolette , Giraldez Teresa , Alvarez de la Rosa Diego
Published: April 2016

The mineralocorticoid receptor (MR) is a member of the nuclear receptor superfamily that transduces the biological effects of corticosteroids. Its best-characterized role is to enhance transepithelial sodium reabsorption in response to increased aldosterone levels. In addition, MR participates in other aldosterone- or glucocorticoid-controlled processes such as cardiovascular homeostasis, adipocyte differentiation or neurogenesis, and regulation of neuronal activity in the hippocampus. Like other steroid receptors, MR forms cytosolic heterocomplexes with heat shock protein (Hsp) 90), Hsp70, and other proteins such as immunophilins. Interaction with Hsp90 is thought to maintain MR in a ligand-binding competent conformation and to regulate ligand-dependent and -independent nucleocytoplasmatic shuttling. It has previously been shown that acetylation of residue K295 in Hsp90 regulates its interaction with the androgen receptor and glucocorticoid receptor (GR). In this work we hypothesized that Hsp90 acetylation provides a regulatory step to modulate MR cellular dynamics and activity. We used Hsp90 acetylation mimic mutant K295Q or nonacetylatable mutant K295R to examine whether MR nucleocytoplasmatic shuttling and gene transactivation are affected. Furthermore, we manipulated endogenous Hsp90 acetylation levels by controlling expression or activity of histone deacetylase 6 (HDAC6), the enzyme responsible for deacetylation of Hsp90-K295. Our data demonstrates that HDAC6-mediated Hsp90 acetylation regulates MR cellular dynamics but it does not alter its function. This stands in contrast with the down-regulation of GR by HDAC6, suggesting that Hsp90 acetylation may play a role in balancing relative MR and GR activity when both factors are co-expressed in the same cell.
Αι φρυκτωρίαι
Authors: ΑΡΧΙΕΠΙΣΚΟΠΟΣ ΙΟΡΔΑΝΟΥ ΤΙΜΟΘΕΟΣ
Published: April 2016

no abstract
Γεύμα του Συμβουλίου της Χριστιανικής Αρχαιολογικής Εταιρείας επί τη τεσσαρακονταετηρίδι αυτής
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Αρχαί της Χριστιανικής Αρχαιολογικής Εταιρείας κατά το έτος 1901
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Μουσείον της Αρχαιολογικής Εταιρείας. Έκθεσις περί των του Μουσείου και Περιηγήσεις του έτους 1902
Authors: ΛΑΜΠΑΚΗΣ Γεώργιος
Published: April 2016

no abstract
Έκθεσις των εργασιών του Διοικητικού Συμβουλίου από 1 Ιανουαρίου - 31 Δεκεμβρίου 1903
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Μουσείον της Χριστιανικής Αρχαιολογικής Εταιρείας. Έκθεσις περί των του Μουσείου και Περιηγήσεις του έτους 1904
Authors: ΛΑΜΠΑΚΗΣ Γεώργιος
Published: April 2016

no absract
Εργασίαι του Διοικητικού Συμβουλίου κατά το 1905
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Δωρεαί εις το Χριστιανικόν Αρχαιολογικόν Μουσείον κατά το έτος 1905
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Πόλεις, μοναί και τόποι, ους τέως επεσκέφθημεν και εξητάσαμεν υπό χριστιανικήν αρχαιολογικήν έποψιν
Authors: ΛΑΜΠΑΚΗΣ Γεώργιος
Published: April 2016

no abstract
Δωρεαί εις το Χριστιανικόν Αρχαιολογικόν Μουσείον κατά το έτος 1908
Authors: ΧΡΙΣΤΙΑΝΙΚΗ ΑΡΧΑΙΟΛΟΓΙΚΗ ΕΤΑΙΡΕΙΑ (ΧΑΕ)
Published: April 2016

no abstract
Time to step up to the plate
Authors: Rawstrone Annette
Published: April 2016

It is vitally important that you provide a balanced diet for your children, in accordance with current guidelines. Writing a food policy is the place to start, and there is plenty of advice available, says Annette Rawstrone.
Fritters hit the spot
Authors: Chapman Ailsa
Published: April 2016

Sweetcorn is generally a favourite and these fritters can be enjoyed hot or cold, says Ailsa Chapman.
How to get it right
Authors: Soar Susan
Published: April 2016

Susan Soar, from the Early Childhood Unit at the National Children's Bureau, reports on what is being learnt from local areas which have implemented the Integrated Review for two-year-olds, and assesses the benefits.
Come into our den
Authors: White Hilary
Published: April 2016

Save the Children's annual Den Day event provides a fantastic opportunity to explore the potential of dens for learning, and develop ideas and discussions around them, says Hilary White.
Ready for Euro 16
Authors: Cruikshank Sarah
Published: April 2016

Children as young as two will be attuned to football through enthusiastic parents and siblings, and by focusing on the European Championships you can give them the opportunity to enjoy new challenges.
On the Principal Permanent Rank Characteristic Sequences of Graphs and Digraphs
Authors: Hassani Monfared Keivan , Horn Paul , Kenter Franklin , Nowak Kathleen , Sinkovic John , Tobin Josh
Published: April 2016

The principal permanent rank characteristic sequence is a binary sequence r_0 r_1 Â· Â· Â· r_n, where r_k = 1 if there exists a principal square submatrix of size k with nonzero permanent and r_k = 0 otherwise, and r_0 = 1 if there is a zero diagonal entry. A characterization is provided for all principal permanent rank sequences obtainable by the family of nonnegative matrices as well as the family of nonnegative symmetric matrices. Constructions for all realizable sequences are provided. Results for skew-symmetric matrices are also included.
Principal Pivot Transforms of Quasidefinite Matrices and Semidefinite Lagrangian Subspaces
Authors: Poloni Federico , StrabiÄ NataÅ¡a
Published: April 2016

Lagrangian subspaces are linear subspaces that appear naturally in control theory applications, and especially in the context of algebraic Riccati equations. We introduce a class of semidefinite Lagrangian subspaces and show that these subspaces can be represented by a subset I â {1, 2, . . . , n} and a Hermitian matrix X â C nÃn with the property that the submatrix X II is negative semidefinite and the submatrix X I c I c is positive semidefinite. A matrix X with these definiteness properties is called I-semidefinite and it is a generalization of a quasidefinite matrix. Under mild hypotheses which hold true in most applications, the Lagrangian subspace associated to the stabilizing solution of an algebraic Riccati equation is semidefinite, and in addition we show that there is a bijection between Hamiltonian and symplectic pencils and semidefinite Lagrangian subspaces; hence this structure is ubiquitous in control theory. The (symmetric) principal pivot transform (PPT) is a map used by Mehrmann and Poloni [SIAM J. Matrix Anal. Appl., 33(2012), pp. 780â805] to convert between two different pairs (I, X) and (J , X 0 ) representing the same Lagrangian subspace. For a semidefinite Lagrangian subspace, we prove that the symmetric PPT of an I-semidefinite matrix X is a J -semidefinite matrix X 0 , and we derive an implementation of the transformation X 7â X 0 that both makes use of the definiteness properties of X and guarantees the definiteness of the submatrices of X 0 in finite arithmetic. We use the resulting formulas to obtain a semidefiniteness-preserving version of an optimization algorithm introduced by Mehrmann and Poloni to compute a pair (I opt , X opt ) with M = max i,j |(X opt ) ij | as small as possible. Using semidefiniteness allows one to obtain a stronger inequality on M with respect to the general case.
ANALYTIC HIERARCHY PROCESS APPLIED TO INDUSTRIAL LOCATION: A BRAZILIAN PERSPECTIVE ON JEANS MANUFACTURING
Authors: Serra Costa Jose Fabiano , Borges Aline Ramos , Machado Thaís Dos Santos
Published: April 2016

The textile sector is one of the most important among all industrial branches. It is important in world commerce because it is a highlight both in the economy of developed countries and in emergent countries. The purpose of this study is to help a Brazilian textile company, which specializes in jeans production, to study the conditions for installing a plant in three possible regions where the most important textile companies of the country are located. In the study, the Analytic Hierarchy Process (AHP), a multicriteria methodology for decision support, is used and results show a slight tendency toward the Rio de Janeiro state when compared to the Santa Catarina state, with both presenting a significant advantage over the Rio Grande do Norte state.
CRITICAL FACTORS IMPORTANT FOR EFFECTIVE INDUSTRY- INSTITUTE INTERACTIONS (III): AN INDIAN PERSPECTIVE
Authors: Kumar Sanjay , Luthra Sunil , Haleem Abid
Published: April 2016

The management of Industry-Institute Interactions (III) has been found to be an important aspect in today’s market. In this paper an attempt has been made to identify Critical Factors (CFs) and rank these for effective III from an Indian perspective. The present paper is based on two research stages. Initially, an extensive literature review was conducted to identify CFs of III. Forty three CFs for effective III were identified and categorized into nine dimensions based on input from experts. In the second stage, the Analytical Hierarchy Process (AHP) was utilized to rank these dimensions and CFs for effective III from an Indian perspective. Paired comparisons in AHP were based on the opinions of experts (selected from academia and industry). The proposed decision framework may offer some valuable guidelines for policy makers to develop their plan of action in terms of design of short and long term policies and strategies to promote effective III in India. A sensitivity analysis was also performed to investigate the robustness and priority ranking stability of CFs in the proposed framework. This paper may help India to achieve and manage effective III leading to potential economic, social, political, cultural and environmental advantages.
Four newly recorded Amanita taxa from India
Authors: SINGH YADWINDER , KAUR MUNRUCHI
Published: April 2016

Singh Y, Kaur M. 2016. Four newly recorded Amanita taxa from India. Biodiversitas 17: 342-348. During the fungal foraysin district Himachal Pradesh of North Western India, four unrecorded taxa of Amanita were collected. They are Amanita flavoconia var.flavoconia, A. flavoconia var. inquinata, A. pilosella f. pilosella and A. porphyria. A. flavoconia var. flavoconia is distinctive in having abrilliant yellow to yellow orange cap, with white lamellae and a stipe base turning light brownish on injury. Whereas. A. flavoconia var.inquinata possesses brownish orange to yellowish orange to orange yellow, subvicid pileus, having white to pastel yellow stipe, annulusgrayish yellow, superior and volva forming broken rings of yellow patches around the bulb. A. pilosella f. pilosella unique in possessinggrayish brown or brownish beige pileus having thick irregular warts and white lamellae edges. A. porphyria is represented by nonstriatepileus margin, off white stipe, decorated with grayish squamules, with violaceous tinge and has a marginate bulb, annulus is persistent,off white above and light grey below and volva is friable, as grey, cottony mass at the margin of the bulb.
The effects of colloids or crystalloids on acute respiratory distress syndrome in swine (Sus scrofa) models with severe sepsis: analysis on extravascular lung water, IL-8, and VCAM-1
Authors: Dewi Rismala , Supriyatno Bambang , Madjid Amir S. , Gunanti Gunanti , Lubis Munar
Published: April 2016

Background: Acute respiratory distress syndrome (ARDS) is a fatal complication of severe sepsis. Due to its higher molecular weight, the use of colloids in fluid resuscitation may be associated with fewer cases of ARDS compared to crystalloids. Extravascular lung water (EVLW) elevation and levels of interleukin-8 (IL-8) and vascular cell adhesion molecule-1 (VCAM-1) have been studied as indicators playing a role in the pathogenesis of ARDS. The aim of the study was to determine the effects of colloid or crystalloid on the incidence of ARDS, elevation of EVLW, and levels of IL-8 and VCAM-1, in swine models with severe sepsis.Methods: This was a randomized trial conducted at the Laboratory of Experimental Surgery, School of Veterinary Medicine, IPB, using 22 healthy swine models with a body weight of 8 to 12 kg. Subjects were randomly allocated to receive either colloid or crystalloid fluid resuscitation. After administration of endotoxin, clinical signs of ARDS, EVLW, IL-8, and VCAM-1 were monitored during sepsis, severe sepsis, and one- and three hours after fluid resuscitation. Analysis of data using the Wilcoxon test , Kolmogorov-Smirnov test, Mann-Whitney test, unpaired t test.Results: Mild ARDS was more prevalent in the colloid group, while moderate ARDS was more frequent in the crystalloid group. EVLW elevation was lower in the colloid compared to the crystalloid group. There was no significant difference in IL-8 and VCAM-1 levels between the two groups.Conclusion: The use of colloids in fluid resuscitation does not decrease the probability of ARDS events compared to crystalloids. Compared to crystalloids, colloids are associated with a lower increase in EVLWI, but not with IL-8 or VCAM-1 levels.
Expression and specific activities of carbamoyl phosphate synthetase 1 in chronic hypoxic rats
Authors: Nikmah Uly A. , Prijanti Ani R. , Jusman Sri W.A. , Sadikin Mohamad
Published: April 2016

Background: Urea biosynthesis is a very important process in the liver which needs ATP, CO2 and functional mitochondria or aerobic condition. Liver can adapt to hypoxic condition, generally and locally. This study aimed to analyze the effect of chronic hypoxia on liver urea biosynthesis as indicated by the level and specific activity of mRNA of carbamoyl phosphate synthetase 1 (CPS1), a key enzyme in urea biosynthesis in hypoxic rats.Methods: 20 male Sprague-Dawley rats were placed in hypoxic chamber supplied by a mixture of 10% O2 and 90% N2. Five rats were sacrificed at 1, 3, 5, and 7 days after exposure. Liver homogenates were analyzed for HIF-1 (hypoxia inducible factor-1) by ELISA, CPS1 mRNA by real time RT-PCR and CPS1 enzymatic specific activities by Pierson method. Data were analyzed by ANOVA test and Pearson correlation.Results: The HIF-1 in liver increased significantly, as well as CPS1 mRNA and CPS1 enzymatic activities (p<0.05). There was a strong correlation (r=0.618; p<0.01) between the level of CPS1 mRNA and CPS1 enzymatic activities, moderate correlation between HIF-1 and CPS1 mRNA (r=0.419; p<0.05) but no correlation between HIF-1 and CPS1 enzymatic activities. The study indicated that urea biosynthesis in liver was affected by hypoxia and partially under HIF-1 regulation. The study also found increase of urea and NH3 biosynthesis related to proteolysis as indicated by the decrease of total body weight and liver weight.Conclusion: There was an increase in the expression and specific activities of CPS1 in urea biosynthesis as a result of increasing proteolysis  in chronic hypoxic condition.
Basal follicle stimulating hormone and leptin on the day of hCG administration predict successful fertilization in in vitro fertilization
Authors: Hestiantoro Andon , Wiweko Budi , Purwaka Robert H.
Published: April 2016

Background: Successful pregnancy in in vitro fertilization (IVF) program depends on multiple factors. This study aimed to determine whether age, body mass index (BMI), basal follicle stimulating hormone (FSH), estradiol, and leptin on the day of trigger ovulation with human chorionic gonadotropin (hCG) might be used as predictor for successful oocyte fertilization in in vitro fertilization (IVF) program.Methods: This is a cross sectional study conducted in Yasmin Fertility Clinic, Cipto Mangunkusumo Hospital, Jakarta, Indonesia. Forty participating patients underwent IVF program, excluding smokers, patients with diabetic, morbid obesity, and severe oligospermia or azoospermia. Age, BMI, basal FSH, estradiol, leptin on the day of hCG administration, oocyte count on oocyte retrieval, the number of mature oocyte, and fertility rate were analyzed using bivariate and multivariate analysis to determine which eligible factors play role in predicting the successful of fertilization.Results: Significant correlation was found between basal FSH level and serum leptin/oocyte ratio on the day of hCG administration with successful fertilization. We found probability formula as follows: 1/(1+exp –(6.2 - 0.4(leptin serum/oocyte ratio) - 0.8(basal FSH)), with 77.8% sensitivity, 77.8% specificity, and AUC levels of 85.6% indicating strong predictability. Probability of successful fertilization related to basal FSH level of 5.90 mIU/mL and leptin serum/oocyte ratio of 3.98.Conclusion: The formula consisting of basal FSH and leptin serum/oocyte ratio on the day of trigger ovulation was capable in predicting the probability of successful fertilization in IVF procedure.
Genetic risk factor APOEε4 associates with plasma amyloid beta in amnestic mild cognitive impairment and alzheimer’s disease
Authors: Situmeang Rocksy F.V. , Wahjoepramono Eka J. , Kaelan Cahyono , Purba Jan S. , Suhadi Budhianto , As'ad Suryani , Aliah Amiruddin , Patellongi Ilham J. , Wahid Syarifuddin
Published: April 2016

Background: APOEε4 is a strong genetic risk factor for Alzheimer’s disease (AD). AD itself has been associated with reduced Aβ clearance from the brain and plasma. Understanding the potential pathogenic link between APOEε4 and plasma Aβ might allow for earlier identification of people at risk of developing AD. The aim of this study is to find out the correlation between APOEε4 and plasma Aβ in amnestic mild cognitive impairment (aMCI) and AD patients.Methods: This is a comparative cross-sectional study of patients attending a memory clinic in Siloam Hospital Lippo Karawaci, Tangerang, during the period of 2013-2014. Subjects were categorized into three categories: normal aging, aMCI, and AD. We performed blood test to examine APOEε4, plasma Aβ4o level, and plasma Aβ42 level. All data analyses were performed using correlation test and logistic regression.Results: Sixty subjects (normal aging = 23, aMCI = 17, AD = 20) were included. There were 19 (31.7%) subjects with APOEε4 positive. Subjects carrying ε4 allele were more likely to have AD by 3.9-fold than subjects with APOE ε4 allele negative. There is a significant difference between the mean of plasma Aβ40 in aMCI group and AD group. We also found correlation between APOEε4 (+) and higher plasma Aβ42 (p<0.05).Conclusion: There is a correlation between APOEε4 and plasma Aβ42 level, which supports the hypothesis that this genetic isoform accelerates the rate and progression of AD through Aβ-dependent pathways.
Avidin inhibits PHA-induced human peripheral blood mononuclear cell proliferation
Authors: Firakania Cicia , Mansur Indra G. , Jusman Sri W.A. , Sadikin Mohamad
Published: April 2016

Background: Cell proliferation occurs not only in normal but also in cancer cells. Most of cell proliferation inhibition can be done by inhibiting the DNA synthesis, notably by intervening the formation of purine or pyrimidine. In purine de novo synthesis, it was assumed that biotin plays a role as a coenzyme in carboxylation reaction, one of the pivotal steps in the purine de novo pathways. The aim of this study was to see the avidin potency to bind biotin and inhibit mitosis.Methods: Peripheral blood mononuclear cell (PBMC) was cultured in RPMI-1640 medium and stimulated by phytohemagglutinin (PHA) in the presence or absence of interleukin-2 (IL-2), with or without avidin. The effect of avidin addition was observed at 24, 48, and 72 hours for cell proliferation, viability, and cell cycle. Statistical analysis was done by one-way ANOVA.Results: Avidin inhibited cell proliferation and viability in culture under stimulation by PHA with and without IL-2. Cell cycle analysis showed that avidin arrested the progression of PBMC after 72 hours of culture. Most cells were found in G0/G1 phase.Conclusion: Inhibition of biotin utilization by avidin binding can halt cell proliferation.
The effect of moderate-intensity acute aerobic exercise duration on the percentage of circulating CD31+ cells in lymphocyte population
Authors: Santosa Mariani , Ilyas Ermita I.I. , Antarianto Radiana D.
Published: April 2016

Background: The increasing number of circulating CD31+ endothelial progenitor cells is one of the important factors for maintaining vascular homeostasis. Exercise will effectively increase the number of circulating CD31+ endothelial progenitor cells. This study aims to determine the effect of moderate-intensity acute aerobic exercise duration on the percentage of circulating CD31+ cells in untrained healthy young adult subjects.Methods: This study was an experimental study. Untrained healthy volunteers (n=20) performed ergocycle at moderate-intensity (64–74% maximum heart rate) for 10 minutes or 30 minutes. Immediately before and 10 minutes after exercise, venous blood samples were drawn. The percentage of CD31+ cells in peripheral blood was analyzed using flow cytometry. Data was statistically analyzed using student t-test.Results: There were no significant differences in the mean percentage of circulating CD31+ cells before and after exercise for 10 minutes and 30 minutes (p>0.05). However, there was a different trend in the percentage of circulating CD31+ cells after exercise for 10 minutes and 30 minutes. In the 10 minutes duration, 50% of subjects showed increase. Whereas in the 30 minutes duration, 80% of subjects showed increase.Conclusion: The percentage of circulating CD31+ cells before and after exercise for 10 minutes was not different compared to 30 minutes. However, data analysis shows that majority of subjects (80%) had increased in the percentage of circulating CD31+ cells after 30 minutes exercise.
A tale of the broken heart: peripartum cardiomyopathy, a case report
Authors: Hariyanto Hori , Yahya Corry Q. , Wibowo Primartanto , Tampubolon Oloan E.
Published: April 2016

Progressive dyspnea following childbirth warrants a prompt suspicion into the diagnosis of peripartum cardiomyopathy, PPCM. Pump failure causes an inadequate cardiac output which ultimately contributes to PPCM high mortality rate; however early airway control, vigilant fluid balance and vasoactive support will substantially reduce the incidence of patients falling into decompensated heart failure. More importantly, it is imperative that these patients are cared in a setting where continuous hemodynamic monitoring is available. This case report serves as a reminder not to focus end-point therapy solely on blood pressure readings, but to observe signs and symptoms of hypoperfusion such as cold clammy skin, cool extremities, decreased urine output and mental status.
Dissolution of large intracardiac thrombus, potential role of the emerging oral fibrinolytic agent
Authors: Candrasatria Rony M. , Kasim Manoefris
Published: April 2016

Intracardiac thrombus may persist in some cases even after anticoagulant therapy. This opens a possibility to add a potent thrombolytic agent into therapeutic regimen without increasing bleeding risk any further. Increasing evidence showed a promising efficacy and safety of oral fibrin specific lumbrokinase as a thrombolytic agent. To the best of our knowledge, report of the use of lumbrokinase on intracardiac thrombus is limited. We reported two cases of intracardiac thrombi. In first patient, after two-month therapy with lumbrokinase, the previous 8 cm2 left atrial thrombus was completely disappeared. Second patient had left ventricular thrombus due to low left ventricular ejection fraction caused by coronary artery disease. A significant dissolution in thrombus size on repeated follow-up was found. Both patients did not experience any significant adverse effect. This case series aims to present the potential use of lumbrokinase as as oral antithrombotic therapy in intracardiac thrombus.
Renal evaluation in patients with type 2 diabetes mellitus and its association with diastolic blood pressure
Authors: Anna Fokine D. , Hugo Mendieta Z. , Ruth Mendieta A.M.
Published: April 2016

Background: HbA1c is correlated with the estimated glomerular filtration rate (eGFR) and diastolic blood pressure (DBP). Our main objective was to evaluate the trend of biochemical and clinical variables, in relation to the eGFR in patients with type 2 diabetes mellitus (T2DM).
Methods: This was a retrospective, longitudinal, and descriptive study, including patients with T2DM, who were cared for from January 2014 until December 2014, at the Clínica de Diabetes, Hospital Regional “Gral. Ignacio Zaragoza", ISSSTE, Mexico City, Mexico. eGFR was calculated using three formulas: the chronic kidney disease – epidemiology collaboration (CKD-EPI), Cockcroft-Gault, and modification of diet in renal disease (MDRD), during two periods of observation, 3 and 6 months. The results were compared by Student t tests or Wilcoxon-Mann-Whitney test depending on the variable distribution. Pearson correlation was employed to determine the relation between the eGFR determined with each formula and the analyzed variables.
Results: The mean age was 56.5±11.3 years in the group of 3 months’ follow-up (n=110) and 57.1±13.8 years in the group of 6 months’ follow-up (n=47). In both groups, the formula with the lowest percentages of cases of CKD was CKD-EPI and the difference of this formula had a basal and final significant positive correlation with the DBP.
Conclusion: The CKD-EPI formula showed the lowest percentages of cases of CKD in a short follow-up period, and its difference is consistently associated with the DBP, confirming the importance of controlling the later to mitigate the evolution to CKD.
X-ray radiation effect of C-arm on adipose tissue-mesenchymal stem cell viability and population doubling time
Authors: Rahyussalim Ahmad J. , Pawitan Jeanne A. , Kusnadi Alam R. , Kurniawati Tri
Published: April 2016

Background: Adipose tissue derived mesenchymal stem cells (AT-MSCs) are relatively easy in isolation procedure compared to bone marrow-derived. Minimally invasive MSC injections need C-arm as guidance that potentially influence the cell viability and doubling time. This study aimsed to determine the effect of C-arm X-ray exposure on AT-MSC viability and population doubling time (PDT).Methods: This experimental study used cryopreserved adipose tissue derived MSCs stored in Stem Cell Medical Technology Integrated Service Unit Cipto Mangunkusumo Hospital. Cells were thawed, propagated, and exposed to varying doses of C-arm X-ray radiation. Stem cell viability was measured, and then the cells were cultured to assess their PDT. Generalized linear models test was used to compare cell viability between post-thaw, post-propagation, post-radiation, post-culture post-radiation, and control and between radiation dose groups. Kruskal-Wallis test assessed PDT between various radiation doses in post-radiation groups. Wilcoxon test was used to assess PDT between pre-radiation and post-radiation groups.Results: Mean confluence period of adipose MSCs post- irradiation was 4.33 days. There was no statistically significant difference in MSC viability after X-ray exposure between pre- and post-irradiation groups (p=0.831). There was no correlation between post-irradiation viability and radiation dose (p=0.138, r=0.503). There were no significant differences in PDT between pre- and post-culture post-irradiation groups and between various radiation doses in post-irradiation groups (p=0.792).  Conclusion: MSC viability and PDT were not influenced by radiation exposure up to 32.34 mgray.
The dream comes true–start for the new beginning
Authors: Nafrialdi Nafrialdi , Widjaja Felix F.
Published: April 2016

[no abstract available]
Representações da Violência por Professores
Authors: Carvalho Maria Das Graças de , Oliveira Gislene Farias de , Carita Ana
Published: April 2016

A violência no espaço escolar tem sido motivo de  preocupação em todo o mundo. O objetivo foi  analisar a violência no espaço escolar, à partir da percepção dos professores no município de Simões-PI. Fizeram parte da amostra, 49 docentes, sendo 77,6%  mulheres e 22,4% homens.   Desses, 98,0% observaram episódios de violência na escola, sendo o tipo mais comum, a patrimonial 28,5%, seguida da física 27,2%; da negligência 22,8% e da psicológica em 21,0% dos casos. Dentre as modalidades mais citadas estiveram presentes nas respostas, a Intimidação (40,8%); a Difamação (16,3%); o Assédio moral (12,2%); a Injúria (4,1%) e, outras (26,5%). Com relação ao local onde foram observadas as violências, Foram citados: Dentro da Escola 40 (81,6%); Na rua 3 (6,1%); Outro lugar 2 (4,1%); Não responderam a esta questão 4 (8,2%). Quanto às Representações sociais de Violência, sobressaiu-se uma única categoria: Ação maléfica. O estudo concluiu que a violência no ambiente escolar ainda necessita ser mais discutida, para que se possa conhecer aspectos associados às diversas variáveis implicadas, não demonstradas no presente estudo. Nesse sentido evidencia-se a importância que se deva dar para a identificação dos possíveis casos de problemas acadêmicos, visando prevenir-se a tempo, as situações de risco.
A Importância do Fator Motivacional no Trabalho
Authors: Soares Vanusa Bezerra dos Santos , Queiroz Luiz Alberto Benevides de , Caffé Filho Hesler Piedade
Published: April 2016

Este artigo objetivou analisar a importância do fator motivacional no ambiente de trabalho, se tratando de uma abordagem critica tratando das relevâncias para o contexto organizacional, na percepção de enxergar os problemas de forma que se possa busque solução deles. Assim propomos um estudo com elementos teórico para responder questionamentos sobre a importância do fator motivacional e como melhor aplicá-los na administração pública observando ainda conflitos entre os objetivos individuais e os objetivos organizacionais. A pesquisa de campo alencou uma maior importância para administração pública, objeto desse estudo, introduza estratégias no contexto que facilitem, dentre outros, o reconhecimento profissional despertando o crescimento profissional através de bons canais de comunicação e plano de cargos e salários bem como o bem estar, pois não se busca máxima eficiência e eficácia nas operações sem a garantia desses fatores influenciadores da motivação. A principal conclusão do trabalho que a desmotivação e apatia dos colaboradores é o resultado da falta de um plano Estratégico dentro da administração pública voltado para gestão de pessoas.
Esgotamento Psicológico no Trabalho: uma análise sob a ótica da Síndrome de Burnout em Professores do Ensino Fundamental
Authors: Silva Quenia Lanusse da , Menezes Thiago Félix De Almeida , Cassundé Fernanda Roda de Souza Araújo
Published: April 2016

Este artigo teve como finalidade avaliar a ocorrência da síndrome de Burnout nos Professores do Ensino Fundamental, do Colégio da Polícia Militar (CPM) no Vale do São Francisco. Foi realizada uma pesquisa quantitativa e empregado o questionário MBI-ED-Maslash Burnout Inventory - Educators Survey (MASLACH; JACKON; LEITER, 1996), versão para professores, com adaptação para uso no Brasil. A pesquisa foi realizada no CPM Alfredo Vianna, localizado em Juazeiro-Bahia. Foi identificado que todos os professores apresentaram indícios de Burnout, devido principalmente à alta carga horária de trabalho e o estresse diário em sala de aula. Este resultado é preocupante, visto que os professores têm no máximo 10 anos de serviço e ainda terão muitos anos de trabalho. É imprescindível a necessidade de transformação na rotina desses profissionais, como diminuição na carga horária e incentivo para capacitações para diminuição do nível de tensão e estresse. Ao mesmo tempo é importante que cada professor procure profissionais capacitados para auxiliarem a prevenir o agravamento dos sintomas, aprimorando a qualidade no seu desempenho profissional e a sua qualidade de vida.
A Gestão de Contratos na Administração Pública
Authors: Gomes Ataniela Rogéria Gonçalves
Published: April 2016

A Gestão de Contratos Administrativos é atualmente uma atividade muito complexa, se considerarmos que operacionalizar a aquisição de um bem é mais simples que se deparar com as etapas burocráticas que lhe antecede ou lhe sucede. Fosse exemplar a etapa preliminar e preparatória (na qual incluímos a elaboração do Termo de Referência e/ou do Projeto Básico, Editais, entre outros) certamente teríamos menos problemas no tocante à gestão e fiscalização dos contratos administrativos em geral. Neste artigo abordamos a importância da atuação de fiscalização e controle do Núcleo de Gestão de Contratos – NGC da Empresa Baiana de Águas e Saneamento S.A. – EMBASA para o aprimoramento da abordagem que faremos em torno da busca pela celebração da melhor aquisição para a melhor consecução dos fins públicos.
Processo de Representação e Participação Social: uma análise crítica
Authors: Nascimento Paulo Sérgio Silvino do , Uchôa Hewelanya De Souza
Published: April 2016

A gestão de bacias hidrográficas assume uma crescente importância no Brasil à medida que aumentam os efeitos de degradação ambiental sobre a disponibilidade de recursos hídricos. Nas regiões hidrográficas, podemos observar tensões entre representação e participação. A participação social se enquadra no processo de redefinição entre o público e o privado, dentro da perspectiva de redistribuir o poder em favor dos sujeitos sociais que geralmente não tem acesso a informação. Desta forma se propõe neste trabalho como objetivo central analisar o processo de representação e participação dos diversos segmentos sociais na gestão do Comitê da Sub-Bacia Hidrográfica do Alto Jaguaribe (CSBHAJ). Como procedimentos metodológicos para a realização da pesquisa, foram utilizados, além dos levantamentos bibliográficos e documentais, a aplicação de entrevistas semiestruturadas e observações sistemáticas. Os resultados demonstraram um elevado grau de concentração da representatividade entre os municípios da sub-bacia, porém, apontando para uma redução desta concentração a partir das alterações nos critérios de eleição para a renovação de nova composição no ano de 2015.
Uma Discussão Teórica sobre a Importância da Gestão do Conhecimento na Administração Pública
Authors: Bezerra Flávia Souza , Souza Ricardo Dos Santos , Cassundé Fernanda Roda de Souza Araújo
Published: April 2016

Na sociedade contemporânea, a gestão pró-ativa dos recursos de conhecimento passou a ser condição sine qua non para a sobrevivência de qualquer entidade. O foco fundamental não é mais o armazenamento e o acesso à informação, mas sim, uma gestão voltada para o conhecimento que reflita na qualidade e resultados dos serviços prestados pela organização. Este trabalho tem como objetivos: discutir questões pertinentes a Gestão do Conhecimento, bem como, averiguar se essa gestão pode contribuir para a geração de resultados positivos na Administração Pública que resulte em benéficios para o cidadão. Conclui-se que a gestão de conhecimento é de suma importância para o desenvolvimento de qualquer empresa, e no que se refere ao nosso objeto de estudo, a administração pública, sua importância se potencializa em decorrência da abrangência que tais instituições possuem para o desenvolvimento de um país; sendo muitas vezes, importante fonte de desenvolvimento interno. Neste sentido, a gestão do conhecimento enriquece a capacidade da administração pública. Todavia, para que tal intento possa ser alcançado, ações precisam ser feitas, onde se deve investir no desenvolvimento e no compartilhamento do conhecimento, seja ele intrínseco ou extrínseco, de tal modo que tal ação torne esse conhecimento fluido, dinâmico, e em movimento.
Poesia e letramento Literário no Ensino Fundamental
Authors: Nunes Ginete Cavalcante
Published: April 2016

O presente trabalho tem como objetivo apresentar algumas considerações a respeito do trabalho em sala de aula com a poesia e quão significativo pode ser o trabalho com esse gênero, pois, na maioria das vezes o poema acaba sendo trabalhado , como pretexto para análise gramatical ou questionamentos sobre seu aspecto formal .Para discorremos sobre o tema temos como base teórica os trabalhos de Bosi (1977 e 1996), Bakhtin (1997), Barthes(1988),Cosson(2006 e 2014) Cunha (2012), Eagleton (2006), Jouve (2012), Lajolo (1982 e 2000), Pinheiro(2002), Sorrenti (2007), Todorov(2009), Zilberman (1988 e 2003), Zumthor (2007), entre outros,na perspectiva de promover estratégias que aprimorem o ensino da Literatura e de propor livros que despertem o interesse dos alunos pela leitura, este texto justifica-se por tornar possíveis percepções sobre questões do ensino do poema  e práticas docentes em literatura mais precisamente com o trabalho com o texto literário, pois este transgride normas, desconstrói a própria linguagem e inaugura mundos possíveis, por meio da transfiguração do real e que desta maneira nos inagamos:Como o uso dos poemas pode influenciar e promover a leitura literária dos alunos do 9º ano do ensino fundamental? Nosso interesse em investigar o referido assunto também justifica-se pela tentativa de contribuir com os debates a respeito do uso de textos literários e dos livros didáticos de Português no ensino de literatura, promovendo assim o letramento literário, práticas estas norteadas por relações muito complexas, que carecem de estudos, reflexões e discussões.
Análise dos Conceitos de poder Disciplinar e Biopoder em Foucault
Authors: Sobral Maria do Socorro Cecílio , Oliveira Sidney Medeiros de
Published: April 2016

O presente trabalho é uma resenha  da obra “Foucault, para além do poder disciplinar e do biopoder” de Thamy Pogrebinschi. Escreve sobre um dos maiores filósofos contemporâneos, sobre as categorias do poder disciplinar e do biopoder, cujo argumento  versa sobre a diferenciação do poder da idéia de repressão , de lei, aproximando-o de algo mais produtivo,  positivo e emancipatório.
Reflexão da Prática Pedagógica na perspectiva de uma Formação Docente Contextualizada
Authors: Alves Maria Aparecida Oliveira , Oliveira Gislene Farias de
Published: April 2016

A formação docente constitui-se um processo contínuo e inacabado, portanto, o professor deve está inserido no processo permanente de desenvolvimento profissional no qual a reflexão seja uma exigência para o fazer docente, uma vez que, uma prática reflexiva é profícua na construção de novos conhecimentos e, influencia positivamente na qualidade da ação pedagógica de um professor.  O presente artigo é resultado de uma pesquisa bibliográfica integrativa da literatura. Enfatiza a formação docente como um fator-chave para a realização de um ensino com qualidade. Tem como objetivo refletir sobre a importância do professor se adequar e atender às novas exigências da sociedade contemporânea que requer profissionais críticos, reflexivos e investigadores capazes de realizar ações criativas e contextualizadas. Nessa perspectiva, é preciso a implementação de políticas educacionais que valorizem o magistério, que incidam em melhores investimentos de modo que os discursos nesse sentido sejam transformados em ações mais efetivas.