bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis of Bacterial Two-component System Inhibitors
Authors:   , Solomin Vitalii
Published: June 2023

The thesis is focused on the development of new histidine kinase two-component systems inhibitors in order to defeat antibiotic resistant bacteria. For the synthesis of perspective inhibitors, synthetic approach of assembling of 2-aminoquinazoline and indazole heterocyclic motifs were elaborated. As a result, a series of new 2-aminoquinazoline-based inhibitors of histidine kinases two-component systems was developed. In addition, perspective phenylazole-based antibacterials active against S. Aureus were studied and described.
Information modeling technologies in the practice of restoration works of architectural heritage monuments
Authors: Prokopenko Il'ya Vladimirovich , Teterina Kristina Sergeevna , Saenko Irina Aleksandrovna
Published: June 2023

The article is devoted to the consideration of the application of modeling technologies during the repair and restoration work of architectural heritage monuments. The author analyzes the methods of building a digital model, as well as the scope of its application. The subject of the article is the technology of information modeling. The purpose of the study was to identify the possibilities and means of using information modeling technologies (TIM) in the practice of carrying out restoration work on cultural heritage objects based on content analysis of available information resources devoted to this subject area, as well as information base, legislative acts and legislative projects regulating the use of information modeling technologies. The article presents the results of experiments and research confirming the effectiveness of the use of information modeling technologies in the practice of restoration work of architectural heritage monuments. The main conclusions confirm that information modeling technologies can significantly improve the accuracy and efficiency of restoration work, allowing more accurately recreate and preserve historical objects in their original form. The scientific novelty of this work lies in the analysis of existing methods used for the construction and further application of information modeling technology in the practice of restoration works of cultural heritage monuments. General summary data on the methods can be used in the work of specialists in restoration, digitalization and conservation of historically important objects.
M. RAVEL'S SPANISH RHAPSODY: TO THE QUESTION OF THE GENRE ORIGINALITY OF THE COMPOSITION
Authors: Cheremnykh Galina Aleksandrovna , Miagkova Svetlana Ivanovna
Published: June 2023

The subject of the study is Maurice Ravel's "Spanish Rhapsody" arranged for two pianos. The purpose of this article is to consider the genre features of the work, based on the refraction of the principles of rhapsody and suite. The performing means used by the composer in the implementation of the program idea of the work are also of research interest. The methodology of this study was made up of holistic and comparative approaches to the study of a musical composition. The novelty of the article lies in the fact that the study generalizes and concretizes the features of form formation in the work, which contributes to the study of the composer's creative method, the study of his peculiarities of working with cyclic forms. In the course of the study, the author comes to the conclusion that in M. Ravel's "Spanish Rhapsody" the features of directly rhapsody are reflected, expressed as a comparison of contrasting folklore layers in a single whole, features of suite, expressed in a generalized interpretation of Spanish imagery on the one hand and the composer's appeal to the genre models of a baroque dance suite, on the other. In addition, the suite principle in the structure of the form of the work is embodied in a specific impressionistic refraction of the genre features of Spanish dance folklore in each of the parts of the form. The obtained results of the work will contribute to the conscious interpretation of M. Ravel's "Spanish Rhapsody" arranged for two pianos from the point of view of the principles and laws of shaping and pianistic means of impressionistic expressiveness in the expression of Spanish images in music.
Coloristic of the film by Bernardo Bertolucci «The Last Emperor»
Authors: Bykova Natalia Ivanovna
Published: June 2023

The subject of the study is Bernardo Bertolucci's film "The Last Emperor", in particular, the coloristic of the film and the psychology of the image of the main character, which is largely revealed through the color palette and individual artistic details. The object of research is the language of cinematography, cinematographic artistic techniques. Despite the sometimes shocking images and plots, Bertolucci's films were highly appreciated by the international community and domestic film critics due to their artistic solution and topical issues affecting the problems of class struggle and anti-fascist themes. The author of the article examines the image of the main character of the film, Aisingero Pu Yi, the last emperor of China and Manchukuo. The film is based on real historical events taking place in the first half of the 20th century, so the dramatic collisions of the character are not perceived by the viewer as some kind of abstract problem. Against the backdrop of the complex historical changes that China has faced, many questions of the formation and self-determination of the individual are being raised. The image of Emperor Pu Yi is revealed gradually through a comparison of two storylines and the color scheme of the film, since it is the color palette that helps to subtly and meaningfully convey the psychological content of the character. The main research methods are analytical and comparative-historical. The composition of the film and the dynamics of the change in the color palette of individual episodes are analyzed, which makes it possible to trace the evolution of the image. The author comes to the conclusion that it was the coloristic solution of the film that allowed the creators to convey the national color and historical atmosphere of China of a certain historical period and show a vivid image of the protagonist on the screen.
Conflictos socioambientales y el rol del turismo: estudio de caso comparado en la Patagonia chilena
Authors: Inostroza-Villanueva Gabriel , Osorio-García Maribel , Farías Aldo
Published: June 2023

En un escenario global de crisis medioambiental, la naturaleza prístina del planeta se encuentra expuesta a presiones de uso intensivo por parte de distintos sectores productivos. En la Patagonia chilena, área reconocida por su valor ambiental, paisajístico y turístico, grandes proyectos energéticos han ocasionado conflictos socioambientales. El propósito de esta investigación es analizar el rol del sector turismo en tres conflictos socioambientales, a través de un estudio de caso comparado. Como hipótesis se plantea que el sector turismo tiene un discurso de oposición a los proyectos energéticos. Sin embargo, los resultados muestran que dicho sector se desenvuelve de manera ambivalente en los conflictos. Por un lado, participa activamente en la oposición a los grandes proyectos energéticos, debido al impacto que generan a la naturalidad del paisaje; y, por otro lado, los visualiza como una oportunidad de desarrollo, en términos de que contribuyen a una mayor turistificación del territorio.
Factores en la decisión de beber agua directamente de la red pública en tres Zonas Metropolitanas de México
Authors: Aguilar-Benitez Ismael
Published: June 2023

La mayoría de la población urbana en México no bebe agua directamente de la red pública, a pesar de contar con este servicio en su vivienda. En este trabajo se analizan algunos aspectos clave que explican esa decisión en tres zonas metropolitanas: Valle de México; Monterrey, estado de Nuevo León; y Villahermosa, estado de Tabasco. Utilizando un modelo econométrico, se estima el efecto de la satisfacción con la calidad del agua y el servicio, y aspectos socioeconómicos y locales que inciden en la decisión de beber agua de la red pública. Los resultados permiten concluir: uno, que promover la ingesta de agua de la llave proveniente de la red pública requiere implementar una regulación efectiva de la calidad del agua suministrada e incentivar un mejor desempeño; y dos, que asegurar la calidad de este servicio debe ser una prioridad de política social, dado que la población con menores ingresos tiene una mayor probabilidad de beber agua de la red pública.
Resiliencia urbana multidimensional en contextos de riesgo: estrategias para el Programa “Quiero Mi Barrio” desde el caso “Barrio Olga Leiva” en Peñalolén
Authors: Insunza Jorge , Jiménez Andrés , Cerda Constanza
Published: June 2023

La resiliencia, un concepto basal en el marco de los actuales enfoques de riesgo de desastre en contextos urbanos, aporta a dichos estudios con perspectivas que incluyen las dimensiones sociológica, económica y medioambiental. La presente investigación ofrece una mirada crítica tanto al concepto de resiliencia urbana, como a su aplicación en el Programa “Quiero Mi Barrio” en un contexto de riesgo de desastre, de manera de formular estrategias que aporten al desarrollo barrial integrado. Para ilustrar este Programa se elige el caso del barrio Olga Leiva, en Peñalolén, conjunto habitacional expuesto al riesgo de la Falla San Ramón. El objetivo es el análisis de la resiliencia social, física y medioambiental de dicho entorno, estudio realizado a partir de entrevistas semiestructuradas y focus groups dirigidos a profesionales y académicos expertos. Se concluye que el conocimiento situado del riesgo con un foco específico en la Falla San Ramón, es instructivo para avanzar en una política pública con enfoque de resiliencia urbana desde una mirada multidimensional.
Migración y vida barrial. Prácticas de apropiación espacial de migrantes haitianos en barrios céntricos y periféricos de Santiago
Authors: Pérez Francisca , Vicencio Tamara
Published: June 2023

El siguiente artículo propone abordar las prácticas espaciales de apropiación del entorno barrial de migrantes haitianos residentes en las comunas de Estación Central y Quilicura de la ciudad de Santiago, Chile. Se plantea indagar, desde una metodología etnográfica que combina biografías migrantes y mapas cognitivos, sobre los posibles conflictos y/o tensiones en relación con los usos del espacio barrial derivados de las prácticas espaciales desplegadas por migrantes que habitan barrios centrales ubicados en las inmediaciones de la comuna de Estación Central, así como de aquellos que durante los últimos años han poblado comunas periféricas de la ciudad de Santiago, como es el caso de la comuna de Quilicura. Los principales resultados apuntan a la relevancia de las adscripciones religiosas y vida sociocultural en el entorno barrial como estrategias de adscripción barrial, en un contexto en el que se ponen en juego las tensiones asociadas a los procesos de desterritorialización y reterritorialización asociados al fenómeno migratorio.
Hydrolysis and Analysis of Agricultural Wastes Using Mineral Acids for Possible Glucose Synthesis
Authors: J. U. Bethel-Wali , Blessing Ohaga , Ifeyinwa Ogbu , Asadu Christian O.
Published: June 2023

This work focuses on conversion of agricultural wastes into fermentable sugar via acid hydrolysis. Proximate and ultimate analysis was carried out to ascertain the physiochemical properties of the biomass feedstock and fermentable sugar. Mineral acid such as hydrochloric acid (HCl) and sulfuric acid (H2SO4) was used as the media for the conversion of plantain peels and water yam peels into fermentable sugar. Concentration of glucose was analyzed using DNS techniques. Modelling of the process was done using three established kinetic models to determine the rate determining step. Results showed that untreated plantain peels and water yam peels contained 30.1% and 6.4% cellulose but increased significantly to 55.1% and 10.03% after hydrolysis indicating increase in fermentable sugar. In comparing the same conditions of plantain-HCl, plantain-HS, water yam-HCl and water yam-HS at 80°C with acid concentration/sample ratio of 0.5:2 at time 90 mins, plantain peels with HCl yield highest concentration of 4.09mg/l fermentable sugar while at the same condition water yam produced 2.031mg/l. Second order kinetic model appears to be the best fit for the process with better correlation coefficient R2 >99% with HCl and plantain peels at a reaction temperature of 60oC conforming to the rate determining step. The model demonstrated an increasing rate constant with increase in temperature which agrees with the magnitude of the hydrolysis process. This work will help in solving the energy need of our society if commercialized. Also, it can serve as a viable alternative to environmental cleanliness because wastes will become raw materials. Plantain peels and water yam peels demonstrated good potential as a source of fermentable sugar but plantain peels performed better.
Constraints and Suggestions Regarding Entrepreneurial Behavior of SHGs Member under National Rural Livelihood Mission (NRLM) in Khanpur Block of Samastipur District in Bihar
Authors: Kumari Jyoti , Jahanara Ms.
Published: June 2023

The present study was undertaken to assess the constraints and suggestions regarding entrepreneurial behaviour of SHG members under the National Rural Livelihood Mission in Khanpur block of Samastipur district in Bihar during the year 2022. The data were collected through a pre-tested schedule from 120 respondents who were selected randomly. The collected data were tabulated, analysed, and interpreted with the help of appropriate statistical tools. The descriptive research design was followed for the current study. It was found that more than half of the respondents, i.e., 48.33 percent, were middle-aged, a large proportion of the members (83.33 percent) were literate, and in the case of size of family, the majority of respondents of small families (up to 4 members) (55.83% and 86.67%) had a nuclear family, and a higher percentage (40.00%) of the respondents had semi-cemented houses. The majority of the respondents depend on agriculture for their livelihood. The major constraints faced by the respondents were the low price of products (67.5%), ranked I, followed by a lack of knowledge about the market trend of SHG products (65.83%), ranked II. The major suggestions given by the respondents were the increase in the price of products (68.34%), ranked I, followed by organising various types of entrepreneurial development programmes (65.83%), ranked II.
Evaluation of Anti-diabetic Activity of Aqueous and Methanolic Extracts of C. tinctorius L. (Safflower Florets)
Authors: Sultana Ayesha , Anwar S. Y. , Hussain Md. Manazzir
Published: June 2023

Alloxan was one of the usual substances used for the induction of diabetes mellitus. It has a destructive effect on the β cells of the pancreas. Glibenclamide was an oral sulphonylurea antidiabetic preparation and widely used as standard drug in antidiabetic study. In the hypoglycaemic study of C. tinctorius L. petals extract in alloxan induced diabetic rats, significant increase in serum fasting blood glucose level with decrease in body weight were observed. On the other hand, petals extract treatment to animals produced a dose related hypoglycaemic effects. The increased blood glucose level was brought down and gain in body weight was seen.

Alloxan effectively induced diabetes in normal rats that are reflected by elevated levels of blood glucose, glycosylated Hb and reduced levels of body weight, liver, pancreas and kidney glycogen, insulin of the injected animals. Treatment with standard drug glibenclamide and methanolic and aqueous extracts of C. tinctorius L. petals reversed these conditions. While comparing plant extracts for antidiabetic study, aqueous extract of C. tinctorius L. petals showed better activity than the methanolic extract. Decrease in glycogen content of liver, pancreas and kidney were in diabetic control rats were due to the leakage of insulin in diabetic state. Prevention of glycogen depletion in the liver following administration of petals extract and standard drug could have been achieved by stimulation of insulin release. The highest improvement was recorded in 600 mg/kg b.w. dosage of C. tinctorius L. (petals).
Inheritance Studies in Segregating Population of Bread Wheat (Triticum aestivum L.)
Authors: Santhoshini A. , Dubey Nidhi , Avinashe Harshal Ashok , Thonta Raju , Kumar Rajneesh
Published: June 2023

The experimental material of present study comprised of 127 treatments and 4 check varieties in augmented design conducted during rabi season (2022) in research field of Genetics and Plant Breeding, Lovely Professional University, Phagwara, India. Observations were recorded for days to 50% heading, days to maturity, plant height, number of productive tillers per plant, ear length, number of spikelets per ear, ear weight, number of grains per ear, test weight, biological yield per plant, harvest index, chlorophyll content and grain yield per plant.  Analysis of variance disclosed that treatments and check varieties are highly significant for all the characters. Phenotypic coefficient of variation noted higher magnitude than genotypic coefficient of variation for all the traits. Heritability combined with genetic advance as percent of mean is noted high for grain yield per plant, biological yield per plant, number of productive tillers per plant, ear weight, harvest index, test weight, ear length, number of spikelets per ear, number of grains per ear and plant height. The correlation coefficient assessed positive and highly significant for biological yield per plant, number of productive tillers per plant, harvest index, ear weight, plant height, test weight and ear length. Grain yield per plant recorded positive significant association with biological yield per plant (0.7816), number of productive tillers per plant (0.7051), harvest index (0.527), ear weight (0.4076), plant height (0.3632), test weight (0.3222), and ear length (0.2439), whereas negatively significantly associated with days to 50% heading (-0.4019) and days to maturity (-0.4019). The findings from path analysis unveiled that the maximum direct effect was noted for biological yield per plant, harvest index, number of spikelets per ear, number of productive tillers per plant, ear weight, days to 50% heading, test weight and days to maturity. Out of thirteen traits, eight traits exhibited direct positive effect on grain yield such as biological yield per plant (0.8282), harvest index (0.6061), number of spikelets per ear (0.107), number of productive tillers per plant (0.0191), ear weight (0.0138), days to 50% heading (0.011), test weight (0.0088), and days to maturity (0.0001).
Performance of Wheat (Triticum aestivum L.) Influenced by the Application of Nano-fertilizers
Authors: Singh Y. K. , Ram Net , Tiwari Vivek Kumar , Singh Balveer , Sharma Uma , Supriya  , Katiyar Drishty
Published: June 2023

An experiment into the "Performance of wheat (Triticum aestivum L.) on application of nano-fertilizers" was conducted on well-drained sandy soil in response to concerns about food and nutritional security as well as second-generation post-green revolution problems, such as increasing input use with declining efficiency trends, deteriorating soil health, depleting water resources, pollution and narrowing farmer profits. On the wheat variety DBW187 in RBD with three replications, 12 twelve treatments containing control, basal administrations of the required 100% NPK (150:60:40), 75% NPK (112.5:45:30), and Nano N and Nano P in various combinations were tried. The study's findings showed that wheat sprayed with 75% NPK + Nano N and Nano P at 30 and 45 days of growth experienced significantly better growth as evidenced by taller plants (91.23 cm), more tillers per square metre (322.5), higher LAI (0.83), and higher dry matter accumulation per square metre (1532.7), all of which were measured at harvest.
Effect of Different Crop Establishment Methods and Weed Management Practices on Growth Indices and Yield of Rice (Oryza sativa L.)
Authors: Maurya Shivanand , Kumar Rajesh , Verma Ravi , Baboo Kaptan , Prakash Ram , Singh A. K.
Published: June 2023

The field experiment was conducted on Agronomy research farm of Acharya Narendra Deva University of Agriculture and Technology Kumarganj Ayodhya (Uttar Pradesh, India) during Kharif season 2021 and 2022. The experiment was laid out in split-plot-design with three replications. Four establishment methods viz., Direct seeded rice, Drum seeder technique, Transplanted rice and System of rice intensification (SRI) were taken in main plot, and six weed management practices viz., Penoxsulam 22.5 g ha-1 at 2-3 leaf stage of weeds DAS/DAT, Penoxsulam 22.5 g ha-1 at 2-3 leaf stage of weeds fb one hand weeding at 35 DAS/DAT, Bispyribac sodium (10%) 25 g a.i. ha-1 at 15 DAS/DAT, Bispyribac sodium (10%) 25 g a.i. ha-1 at 15 DAS/DAT fb one hand weeding at 35 DAS/DAT, Weed free (Two hand weeding) and Weedy check in sub plot. Result revealed that significantly higher crop growth rate, relative growth rate, absolute growth rate, net assimilation rate and grain yield was recorded in system of rice intensification (SRI) during both the years of investigation. Among the weed management practices, higher value recorded with spray of Bispyribac sodium (10%) 25 g a.i. ha-1 at 15 days after sowing/days after transplanting fb one hand weeding at 35 DAS/DAT.
The Effect of Visual Merchandise and Store Atmosphere on Purchase Decision with Hedonic Orientation as Moderator
Authors: Susanto Giovani Anggasta , Adiwijaya Michael
Published: June 2023

The development of the retail industry in Indonesia has been affected by the covid-19 pandemic that has entered Indonesia since 2019. To restore the situation, retail business players must find ways to increase their turnover through increased sales which can be achieved by purchasing decisions by consumers. This study examines the effect of visual merchandise and store atmosphere on purchase decisions moderated by hedonic orientation. This research uses customers of the KKV store in Surabaya as objects, and there are 110 valid samples obtained from the data collection using a questionnaire. The results showed that visual merchandise, store atmosphere, and hedonic orientation significantly affect purchase decisions. In addition, hedonic orientation as a moderator does not significantly affect purchase decisions.
The effect of COVID-19, Non-performing Loans, and Non-Interest Income on Bank Performance
Authors: Indah Christina , Rokhim Rofikoh
Published: June 2023

The COVID-19 pandemic that has hit the entire world has also had a major impact on the banking industry at the global level. Therefore, this study aims to examine the effects of the COVID- 19 pandemic, non-performing loans, and non-interest income in ASEAN-5 countries from the first quarter of 2020 to the fourth quarter of 2021. The sample consists of 86 banks listed in the capital markets of Indonesia, Malaysia, Thailand, Singapore, and Philippines. The research method used is panel regression estimated using fixed effect model and random effect model. The results showed that COVID-19 had a significant positive effect on net income after taxes, while non-performing loans also had a significant and negative effect on banking performance. However, there is no significant role in non-interest income in banking in ASEAN-5.
Dimensions of Interest in Using E-Wallets in Online Transportation Service
Authors: Purnamawati I Gusti Ayu , Yuniarta Gede Adi , Herliyani Elly
Published: June 2023

There are still many MSME actors who have not used e-wallets, especially in using online transportation. This paper examines the Utilitarianism, trust, risk perception, reputation, and costs of e-wallet users' interest in online transportation. This research uses quantitative methods. A questionnaire was used to collect data from 110 small and medium-scale entrepreneurs in Bali Province. Multiple linear regression analysis tests are used to test the interest of e-wallet users. The results show that the utilitarian variables, trust, and reputation, positively and significantly affect e-wallet user interest. At the same time, risk perceptions and cost do not affect e-wallet user interest. These costs are burdensome for consumers to purchase mobile devices to take advantage of digital payment services, so it takes time and effort to consider adopting new technology. Inclusive finance is an important entry point for inclusive growth; e-wallets also help Micro, Small, and Medium Enterprises currently being promoted by the government to support the economy. TAM is a model that theoretically helps predict and explain user acceptance of information technology. Digital payment solutions allow consumers and merchants to use social media to buy and sell goods and services to create new economic opportunities.
Inteligência Artificial e Direitos Autorais: um mapeamento da produção científica
Authors: Valente Catherine , Sartori Rejane , Marin João Paulo
Published: June 2023

As questões que envolvem o estudo de Direitos Autorais e Inteligência Artificial despertam acalorados debates e pouco consenso. Contudo, inafastável o aprofundamento de tal estudo para tentar regular a rápida evolução da sociedade informacional. Nesse contexto, o objetivo deste artigo é mapear a produção científica sobre Inteligência Artificial e Direitos Autorais, a fim de compor um portfólio bibliográfico consistente que permita estabelecer uma revisão da literatura aprofundada sobre o tema no futuro. Este estudo é de natureza descritiva e exploratória. O procedimento técnico utilizado é a pesquisa bibliográfica, instrumentalizada pelo Knowledge Development Process-Constructivist (ProKnow-C). Os resultados revelam que os artigos selecionados para compor o portfólio bibliográfico desta pesquisa se apresentam como um bom parâmetro do estado da arte, bem como demonstram a relevância do tema a nível mundial. O estudo proporciona a continuidade da pesquisa no futuro por meio de uma análise tanto qualitativa quanto quantitativa.
Indicação Geográfica da Região do Jalapão: estudo de caso da atuação do substituto processual após a concessão da indicação de procedência
Authors: Silva Fernando Melo da , Sales Marcos Augusto  Oliveira , Santos Junior Elias Lira dos , Assis Luis Paulo Castro de
Published: June 2023

A Região do Jalapão no Estado do Tocantins é tradicional pelo artesanato em capim dourado, reconhecido como Indicação de Procedência pelo Instituto Nacional da Propriedade Industrial (INPI). Com o reconhecimento da Indicação Geográfica surge a questão da atuação do substituto processual na gestão dos direitos e interesses a ela referentes, sendo o objetivo deste artigo analisar a atuação da Associação dos Artesãos em Capim Dourado da Região do Estado de Tocantins, de modo a identificar os reflexos na proteção dos produtos do artesanato em capim dourado. Utilizou-se do método de abordagem hipotético-dedutivo, com procedimento de estudo de caso pautado em revisão bibliográfica e documental, cujos resultados são a verificação da ausência de controle e a defesa do artesanato em capim dourado, pela falta de representatividade e de participação dos artesãos locais na formação e gestão do substituto processual, já que sua criação decorreu de incentivo estatal que, inclusive, a situou fora da área da Região do Jalapão.
Nanocompósitos para a Adsorção de Fármacos: estudo e monitoramento tecnológico
Authors: Rodrigues Meiry Gláucia Freire , Silva Francisco Alex de Sousa , Segundo Valdirio Alexandre Gadelha , Villarim Priscila Rodrigues Moreira
Published: June 2023

A presença de compostos farmacêuticos tem sido amplamente detectada em águas e efluentes devido, principalmente, ao aumento na sua produção e no consumo. A grande demanda mundial por baixo impacto ambiental, combinada à necessidade crescente de processos de água e esgoto mais eficientes e competitivos, uma vez que os tratamentos convencionais não são capazes de remover totalmente esses microcontaminantes, tem motivado a busca de tecnologias mais eficientes, como adsorção, além da utilização da nanotecnologia, por exemplo, os nanoadsorventes. Este artigo aborda um estudo e monitoramento tecnológico da produção de nanocompósitos para a adsorção de fármacos, usando patentes como fontes de informação. Para levantamento dos dados foi utilizada a plataforma Questel Orbit®, aplicando como entrada as palavras-chave para as buscas “composite”, “adsorption”, “drugs”. Os resultados da prospecção de patentes indicaram que as universidades e as instituições de pesquisa chinesas possuem a maior parcela de patentes depositadas e entre as tecnologias relacionadas aos nanocompósitos os métodos de síntese e sua aplicação em membranas e na catálise foram as que mais se destacaram.
Propriedade Intelectual e Ativos Intangíveis: um estudo em companhias nordestinas de capital aberto
Authors: Farias Edilma Correia de , Silva Patricia Brandao Barbosa da , Santos Cristiano da Silva
Published: June 2023

A ideia de tratar a inovação, os ativos intangíveis e a propriedade intelectual como capital intelectual surgiu da necessidade de reestruturar os modelos de gestão, de reconhecimento e a avaliação do conhecimento nas empresas. O objetivo deste artigo foi verificar em que nível os ativos intangíveis estão protegidos por direitos de propriedade intelectual nas empresas nordestinas listadas na bolsa de valores Brasil, Bolsa, Balcão-B3. Para verificar a existência de ativos intangíveis e sua proteção nas companhias selecionadas, foram analisados os relatórios e demonstrativos financeiros publicados na bolsa de valores B3 juntamente com informações fornecidas pelo Instituto Nacional da Propriedade Industrial (INPI). A análise foi realizada usando estatística descritiva e análise exploratória de dados, por meio de gráficos e tabelas. Foram analisadas 31 companhias, 28 delas possuem ativo intangível e 26 possuem algum tipo de propriedade intelectual. Apenas 5% dos ativos intangíveis são protegidos por direitos de propriedade intelectual. Os softwares, seguido das marcas, e depois marcas e patentes, são as principais propriedades intelectuais usadas pelas empresas nordestinas.
REFLEXÕES SOBRE O DIREITO AO TRABALHO NO BRASIL SOB A ÓTICA DA TEORIA CRÍTICA DOS DIREITOS HUMANOS E DA INTERSECCIONALIDADE
Authors: Oliveira Damaris de
Published: June 2023

Este estudo apresenta uma reflexão sobre como as relações de trabalho produzem hierarquias e opressões e como as categorias gênero, raça e classe influenciam na dinâmica das desigualdades sociais. Para tanto, o objetivo geral é aproximar as discussões da teoria da interseccionalidade (CRENSHAW, 2002; COLLINS; BILGE, 2020) e o conceito de dignidade humana (FLORES, 2009) a fim de compreender quais são os impactos da intersecção daquelas categorias sociais no direito ao trabalho. Como procedimentos metodológicos, destacam-se a pesquisa qualitativa bibliográfica e documental.
The gender principle in law as a guarantee of equality in legal regulation
Authors: Protosavitska Liudmyla , Omelchenko Nataliia L. , Kuderska Nadiia I. , Samilyk Liudmyla O. , Andrusiak Iryna
Published: June 2023

The development of modern Ukraine on the basis of the new forms of social relations between the sexes must be carried out in accordance with world universal standards of human rights and equality between the sexes. The article defines the need for a more specific view of gender equality. Using the historical approach and different theoretical methods, the article attempts to systematize knowledge about feminism, gender, transgender, human rights and opportunities of people. The article contains an analysis of gender discrimination and violence and defines ways of overcoming them. The study focuses on the legal aspects of equal rights and opportunities in both international legal acts and Ukrainian legislation. The paper studied how a gender approach in politics, economics and social spheres was being developed. Measures taken to ensure the equal distribution of family responsibilities, ensuring a reduction in the gender pay gap, were analyzed. The main areas of gender equality guaranteed by international and domestic law were identified as follows: equal access to management positions, access to labor market participation, elimination of occupational segregation, violence and discrimination based on gender, unpaid time off, etc. The priorities of the state gender policy for the last 5 years were investigated.
Agresiones sexuales múltiples en España. Un estudio a partir del crime scripting
Authors: Mesa María José Rodríguez
Published: June 2023

Mediante este estudio, de naturaleza exploratoria, se proporciona un análisis teórico del proceso de comisión del crimen en los supuestos de agresiones sexuales múltiples utilizando la metodología del Crime Script a partir de los datos obtenidos en una muestra de sentencias condenatorias. Los resultados permiten una mejor comprensión del proceso de comisión del delito de agresión sexual múltiple a mujeres en los casos resueltos y condenados, de modo que pueda servir de base para el establecimiento de estrategias policiales y de prevención situacional del delito que puedan disuadir este tipo de crímenes sexuales ya en las primeras etapas del proceso.
AS NOVAS DIRETRIZES PARA O NOME E SEXO/GÊNERO NO ORDENAMENTO JURÍDICO PÁTRIO
Authors: Cunha Leandro Reinaldo da
Published: June 2023

Uma visão panorâmica das alterações normativas com relação ao nome e ao sexo/gênero nos documentos.
ATLETAS TRANSGÊNERO E ESPORTES DE ELITE
Authors: Cunha Leandro Reinaldo da
Published: June 2023

Tradução do sumário executivo “ATLETAS TRANSGÊNERO E ESPORTES DE ELITE: UMA REVISÃO CIENTÍFICA“, uma importante pesquisa realizada pelo Canadian Centre for Ethics in Sports que compilou anos de estudos sobre o impacto da participação de mulheres transgênero nos esportes de elite e constatou, ao fim e ao cabo, que não há evidencias de que a sua presença competindo com mulheres cisgênero traria alguma vantagem competitiva injusta.
Skin Lesions, Foot Drop, and Hand Contractures
Authors: Filley Aidan R. , Saad Saadeddine , Altman Kirstin
Published: June 2023

A previously healthy individual in his 20s had 3 months of annular skin lesions, with numbness and paresthesia in the affected areas. Physical examination revealed multiple tattoos, bilateral palpable thickened auricular and ulnar nerves, and claw-hand deformity; test results for rapid plasma reagin, antinuclear antibodies, rheumatoid factor, acid-fast bacilli, mycobacteria, and fungi were negative, and biopsy did not identify Mycobacterium leprae. What is the diagnosis and what would you do next?
Estimating Patient-Specific Relative Benefit of Adding Biologics to Conventional Rheumatoid Arthritis Treatment
Authors: Luo Yan , Chalkou Konstantina , Funada Satoshi , Salanti Georgia , Furukawa Toshi A.
Published: June 2023

Importance

Current evidence remains ambiguous regarding whether biologics should be added to conventional treatment of rheumatoid arthritis for specific patients, which may cause potential overuse or treatment delay.

Objectives

To estimate the benefit of adding biologics to conventional antirheumatic drugs for the treatment of rheumatoid arthritis given baseline characteristics.

Data Sources

Cochrane CENTRAL, Scopus, MEDLINE, and the World Health Organization International Clinical Trials Registry Platform were searched for articles published from database inception to March 2, 2022.

Study Selection

Randomized clinical trials comparing certolizumab plus conventional antirheumatic drugs with placebo plus conventional drugs were selected.

Data Extraction and Synthesis

Individual participant data of the prespecified outcomes and covariates were acquired from the Vivli database. A 2-stage model was fitted to estimate patient-specific relative outcomes of adding certolizumab vs conventional drugs only. Stage 1 was a penalized logistic regression model to estimate the baseline expected probability of the outcome regardless of treatment using baseline characteristics. Stage 2 was a bayesian individual participant data meta-regression model to estimate the relative outcomes for a particular baseline expected probability. Patient-specific results were displayed interactively on an application based on a 2-stage model.

Main Outcomes and Measures

The primary outcome was low disease activity or remission at 3 months, defined by 3 disease activity indexes (ie, Disease Activity Score based on the evaluation of 28 joints, Clinical Disease Activity Index, or Simplified Disease Activity Index).

Results

Individual participant data were obtained from 3790 patients (2996 female [79.1%] and 794 male [20.9%]; mean [SD] age, 52.7 [12.3] years) from 5 large randomized clinical trials for moderate to high activity rheumatoid arthritis with usable data for 22 prespecified baseline covariates. Overall, adding certolizumab was associated with a higher probability of reaching low disease activity. The odds ratio for patients with an average baseline expected probability of the outcome was 6.31 (95% credible interval, 2.22-15.25). However, the benefits differed in patients with different baseline characteristics. For example, the estimated risk difference was smaller than 10% for patients with either low or high baseline expected probability.

Conclusions and Relevance

In this individual participant data meta-analysis, adding certolizumab was associated with more effectiveness for rheumatoid arthritis in general. However, the benefit was uncertain for patients with low or high baseline expected probability, for whom other evaluations were necessary. The interactive application displaying individual estimates may help with treatment selection.
Design Parameters for Injectable Biopolymeric Hydrogels with Dynamic Covalent Chemistry Crosslinks
Authors: de Paiva Narciso Narelli , Navarro Renato S. , Gilchrist Aidan E. , Trigo Miriam L. M. , Aviles Rodriguez Giselle , Heilshorn Sarah C.
Published: June 2023

Dynamic covalent chemistry (DCC) crosslinks can form hydrogels with tunable mechanical properties permissive to injectability and self‐healing. However, not all hydrogels with transient crosslinks are easily extrudable. For this reason, two additional design parameters must be considered when formulating DCC‐crosslinked hydrogels: 1) degree of functionalization (DoF) and 2) polymer molecular weight (MW). To investigate these parameters, hydrogels comprised of two recombinant biopolymers: 1) a hyaluronic acid (HA) modified with benzaldehyde and 2) an elastin‐like protein (ELP) modified with hydrazine (ELP‐HYD), are formulated. Several hydrogel families are synthesized with distinct HA MW and DoF while keeping the ELP‐HYD component constant. The resulting hydrogels have a range of stiffnesses,G′ ≈ 10–1000 Pa, and extrudability, which is attributed to the combined effects of DCC crosslinks and polymer entanglements. In general, lower MW formulations require lower forces for injectability, regardless of stiffness. Higher DoF formulations exhibit more rapid self‐healing. Gel extrusion through a cannula (2 m length, 0.25 mm diameter) demonstrates the potential for minimally invasive delivery for future biomedical applications. In summary, this work highlights additional parameters that influence the injectability and network formation of DCC‐crosslinked hydrogels and aims to guide future design of injectable hydrogels.
Mechanochemical Degradation of Poly(vinyl chloride) into Nontoxic Water‐Soluble Products via Sequential Dechlorination, Heterolytic Oxirane Ring‐Opening, and Hydrolysis
Authors: Choudhury Neha , Kim Ahyun , Kim Minseong , Kim Byeong‐Su
Published: June 2023

As one of the most widely used commodity plastics, poly(vinyl chloride) (PVC) is extensively used worldwide, yet is difficult to recycle and is often discarded immediately after use. Its end‐of‐life treatment often generates toxic hydrogen chloride and dioxins that pose a critical threat to ecosystems. To address this challenge, the mechanochemical degradation of PVC into water‐soluble biocompatible products is presented herein. Oxirane mechanophores are strategically introduced into the polymeric backbone via sequential dechlorination followed by epoxidation. The oxirane mechanophore in the polymer backbone undergoes a force‐induced heterolytic ring‐opening to carbonyl ylide intermediates, which eventually generates acetals during the course of the reaction. The subsequent hydrolysis of the backbone acetals affords the scission of the polymeric chain into water‐soluble low‐molecular‐weight fragments. Combined with its low cytotoxicity and phytotoxicity, this solvent‐free mechanochemical degradation process offers a green alternative for the degradation of PVC.
Arbitrary Optical Wavefront Shaping with Holographic Plasmonic Gap Waveguides
Authors: Zhou Guang Zhu , Chen Bao‐Jie , Wu Geng‐Bo , Qu Shi‐Wei , Chan Chi Hou
Published: June 2023

Manipulations of free‐space light are usually achieved through various metasurfaces and spatial light modulators. However, an external light source is required to excite these devices, making complete on‐chip integrations difficult. Integrated photonics enables the miniaturization and multi‐functionalization of optical systems by densely packing numerous optical components on a single chip. Particularly, plasmons have recently attracted extensive attention due to their unique abilities to enable the routing and manipulation of light at the nanoscale. Here optical wavefront shaping achieved by holographic metal‐insulator‐metal plasmonic gap waveguides is reported. An arbitrary free‐space wave's amplitude and phase information can be recorded in the waveguide by the amplitude variation of the guided wave. By elaborately designing the plasmonic gap waveguide, the guided waves can be molded into any desired free‐space light field, thus enabling complex free‐space functions including highly directional beams, dual beams with arbitrarily tailorable power ratio and radiation angles, focusing beams, and Airy beam generation. This study opens a new route for optical wavefront shaping via modulating guided waves. It paves the way for optical interconnects across multifunctional photonic integrated devices and free space, holding potential in optical communications, light detection and ranging, imaging, and displays.
A Route to Ultra‐Fast Amplitude‐Only Spatial Light Modulation using Phase‐Change Materials
Authors: Shields Joe , De Galarreta Carlota Ruiz , Penketh Harry , Au Yat‐Yin , Bertolotti Jacopo , Wright C. David
Published: June 2023

A phase‐change material based, thin‐film, amplitude‐only spatial light modulator is presented. The modulator operates in reflection and modulates the amplitude of light incident on its surface with no effect on optical phase when the phase‐change material is switched between its amorphous and crystalline states. This is achieved using a thin‐film device with an embedded, switchable, GeTe phase‐change layer. Test modulation patterns are written to the device using laser scans, and the amplitude and phase response measured, using optical spectroscopy and off‐axis digital holography. Experimental results reveal reflected intensity to be modulated by up to 38%, with an averaged phase difference of less than ≈π/50. Since phase‐change materials such as GeTe can be switched on sub‐microsecond timescales, this approach maps out a route for ultra‐fast amplitude spatial light modulators with widespread applications in fields such as wavefront shaping, communications, sensing, and imaging.
Near‐IR Electrochromic Dihydroindolo(2,3a)carbazole‐Based Macrocycles and Their [b]‐Annulated BODIPY Complexes
Authors: Spergen Aswini , Kalaiselvan Arumugam , Gokulnath Sabapathi
Published: June 2023

A new class of redox‐active dihydroindolo(2,3a)carbazole(InC)‐based porphyrin‐like macrocycles (thiophene embedded: InCT and p–phenylene embedded: InCB) and the corresponding [b]‐annulated BODIPY complexes (InCTBF2 and InCBBF2) are reported. A facile synthetic methodology is adopted to accomplish the new expanded‐porphyrin‐like macrocyclic systems using the key precursor 11 based on 11,12‐dihydroindolo(2,3a)carbazole building block 4. In these macrocyclic systems, the subunit 4 is deemed to be a donor and an azafulvene‐extended with π‐conjugated fragment (thiophene or p‐phenylene) acts as an acceptor. Single crystal X‐ray structures are obtained for both InCT and InCB. Spectroelectrochemical studies on these macrocycles and their BF2 complexes display intriguing near‐IR electrochromic properties with reversible multi‐color switching upon cathodic scans at room temperature. InCTBF2 shows high stability with a radical comproportionation constant (Kc) of 1.22 × 106. Thiophene and p‐phenylene subunits in InCT and InCB exhibit ring rotation at room temperature as evident from NMR studies. Such ring rotation is restricted upon BF2 complexation, and they show unusual stability in acidic conditions.
Autophagosomes Defeat Ferroptosis by Decreasing Generation and Increasing Discharge of Free Fe2+ in Skin Repair Cells to Accelerate Diabetic Wound Healing
Authors: Cui Shengnan , Liu Xi , Liu Yong , Hu Wenzhi , Ma Kui , Huang Qilin , Chu Ziqiang , Tian Lige , Meng Sheng , Su Jianlong , Zhang Wenhua , Li Haihong , Fu Xiaobing , Zhang Cuiping
Published: June 2023

Ferroptosis plays an essential role in the development of diabetes and its complications, suggesting potential therapeutic strategies targeting ferroptosis. Secretory autophagosomes (SAPs) carrying cytoplasmic cargoes have been recognized as novel nano‐warrior to defeat diseases. Here, it is hypothesized that SAPs derived from human umbilical vein endothelial cells (HUVECs) can restore the function of skin repair cells by inhibiting ferroptosis to promote diabetic wound healing. High glucose (HG)‐caused ferroptosis in human dermal fibroblasts (HDFs) is observed in vitro, which results in impaired cellular function. SAPs successfully inhibit ferroptosis in HG‐HDFs, thereby improving their proliferation and migration. Further research show that the inhibitory effect of SAPs on ferroptosis resulted from a decrease in endoplasmic reticulum (ER) stress‐regulated generation of free ferrous ions (Fe2+) in HG‐HDFs and an increase in exosome release to discharge free Fe2+ from HG‐HDFs. Additionally, SAPs promote the proliferation, migration, and tube formation of HG‐HUVECs. Then the SAPs are loaded into gelatin‐methacryloyl (GelMA) hydrogels to fabricate functional wound dressings. The results demonstrate the therapeutic effect of Gel‐SAPs on diabetic wounds by restoring the normal behavior of skin repair cells. These findings suggest a promising SAP‐based strategy for the treatment of ferroptosis‐associated diseases.
Gibbs Adsorption and Zener Pinning Enable Mechanically Robust High‐Performance Bi2Te3‐Based Thermoelectric Devices
Authors: Zhang Chaohua , Lai Qiangwen , Wang Wu , Zhou Xuyang , Lan Kailiang , Hu Lipeng , Cai Bowen , Wuttig Matthias , He Jiaqing , Liu Fusheng , Yu Yuan
Published: June 2023

Bi2Te3‐based alloys have great market demand in miniaturized thermoelectric (TE) devices for solid‐state refrigeration and power generation. However, their poor mechanical properties increase the fabrication cost and decrease the service durability. Here, this work reports on strengthened mechanical robustness in Bi2Te3‐based alloys due to thermodynamic Gibbs adsorption and kinetic Zener pinning at grain boundaries enabled by MgB2 decomposition. These effects result in much‐refined grain size and twofold enhancement of the compressive strength and Vickers hardness in (Bi0.5Sb1.5Te3)0.97(MgB2)0.03 compared with that of traditional powder‐metallurgy‐derived Bi0.5Sb1.5Te3. High mechanical properties enable excellent cutting machinability in the MgB2‐added samples, showing no missing corners or cracks. Moreover, adding MgB2 facilitates the simultaneous optimization of electron and phonon transport for enhancing the TE figure of merit (ZT). By further optimizing the Bi/Sb ratio, the sample (Bi0.4Sb1.6Te3)0.97(MgB2)0.03 shows a maximum ZT of ≈1.3 at 350 K and an average ZT of 1.1 within 300–473 K. As a consequence, robust TE devices with an energy conversion efficiency of 4.2% at a temperature difference of 215 K are fabricated. This work paves a new way for enhancing the machinability and durability of TE materials, which is especially promising for miniature devices.