bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychological Intervention Improves Quality of Life, but Not Survival in Patients with Early-Stage Cancer: a Systematic Review and Meta-analysis of randomized clinical trials
Authors: Bognar Anna , Teutsch Brigitta , Bunduc Stefania , Veres Daniel , Szabo Bence , Fogarasi Beatrix , Zahariev Olga , Vorhendi Nora , Almog Omer , Hadani Yael , Gergo Dorottya , Mihaly Emese , Balint Eross , Marta Katalin , Hegyi Peter
Published: October 2023

The effectiveness of psychological interventions (PI) for malignant diseases is still controversial. Our aim was to investigate the effect of PI on survival and quality of life (QoL) in patients with cancer. We performed a systematic search of MEDLINE, Cochrane, and Embase databases to identify randomized controlled trials comparing PI to standard care (PROSPERO registration number CRD42021282327). Outcomes were overall survival (OS), recurrence-free survival (RFS), and different domains of QoL: global, emotional, social, and physical. A subgroup analysis was performed based on provider, type, environment, duration, and cancer stage of intervention. Pooled hazard ratios (HR) and standardized mean difference (SMD) with 95% confidence intervals (CI) were calculated using a random-effects model. We found 129 articles eligible for data analysis. The OS and RFS did not differ significantly between the PI and the standard care groups (OS: HR=1.01; CI: 0.95-1.07; RFS: HR=0.99; CI: 0.84-1.16). However, our analysis showed significant improvements in the intervention group in all the analyzed domains of QoL; in the global (SMD=0.84; CI: 0.37-1.31), emotional (SMD=0.52; CI: 0.20-0.83), physical (SMD=0.45; CI: 0.11-0.79) and social (SMD=0.34; CI: 0.08-0.60) domains. Importantly, the effect of PI on QoL was generally positive immediately, 12 and 24 weeks after intervention, but PI decreased over time, and was no longer found significant at 48 weeks. The results were better in early stages of cancer. Psychological interventions do not prolong survival, but they significantly improve the QoL of cancer patients. Our results suggest that PI should be standard of care for 3-4 times a year at least for patients especially with early-stage cancer.
Hierarchy of Design Needs for Enabling Reverse Logistics Activities: A Design for Reverse Logistics Approach
Authors: Costa Ana Luiza Cabral , Martins Vitor William Batista , Chaves Liliane Iten , Braga Antonio Erlindo , Melo André Cristiano Silva
Published: October 2023

In the current global context marked by rampant consumption, excessive waste disposal, and dwindling natural resources, Reverse Logistics emerges as a viable solution. This research adopts a Design for Reverse Logistics approach to identify essential Design Needs associated with Reverse Logistics, contributing to sustainable product development methodologies. Its primary objective is to enhance the efficiency of RL activities and processes. This exploratory research combines bibliographic analysis and surveys in a qualitative-quantitative approach, drawing insights from experts in Reverse Logistics, Circular Economy, and Sustainable Design. To ensure the reliability of our findings, we utilize Cronbach's Alpha coefficient and apply the TOPSIS multicriteria decision support analysis method for data processing. The outcome of expert analysis is a hierarchical arrangement of Design Needs, providing valuable recommendations for future research. In summary, this research delves into the intricacies of Reverse Logistics, aiming to address the pressing global issues of resource scarcity and unsustainable consumption. By identifying critical Design Needs, it offers a pathway towards more sustainable product development practices in an increasingly resource-constrained world.
Early Fluid is Less Fluid: Comparing Early Versus Late Resuscitation in Severely Injured Trauma Patients
Authors: Beni Catherine E. , Arbabi Saman , Robinson Bryce R.H. , O’Keefe Grant E.
Published: October 2023

Background: We aimed to characterize the temporal trends of crystalloid resuscitation in severely injured trauma patients after intensive care unit (ICU) admission. Using 500 mL/hr of crystalloid in the first 6 hours of ICU admission to distinguish early versus late resuscitation, we hypothesized early resuscitation was associated with less volume by 48 hours and better outcomes compared with late resuscitation.
Methods: We performed a retrospective review of the trauma registry of a high-volume level 1 academic trauma center to examine adult trauma patients admitted to the ICU (2016-2019) with: with initial serum lactate ≥ 4 mmol/dL, elevated lactate (≥ 2 mmol/L) at ICU admission, and lactate normalization within 48 hours. We analyzed patient and injury characteristics, and the first 48 hours of ICU course. The primary outcome was ICU length of stay (LOS); secondary outcomes included ventilator days, acute kidney injury (AKI), and in-hospital death. We compared subjects who received early resuscitation to those received late resuscitation using unadjusted methods and multivariable regression models.
Results: We analyzed 333 subjects. The late resuscitation group received less volume over the first 24 hours, but surpassed the early group by 48 hours (5.5 vs 4.1L, p ≤ 0.001). The late group had longer ICU LOS (9 vs 5 days, p ≤ 0.001) and ventilator days (5 vs 2 days, p ≤ 0.001), and higher incidence of AKI (38% vs 11%, p ≤ 0.001). On multivariable regression, late resuscitation remained associated with longer ICU LOS and ventilator days, and higher odds of AKI after adjusting for important confounders.
Conclusions: After hemostasis, crystalloid can play an important role in restoration of organ perfusion. Delaying resuscitation is associated with both receipt of higher volumes of crystalloid by 48 hours and worse outcomes compared to early resuscitation. Judicious crystalloid given early in ICU admission could improve outcomes in the severely injured.
Rational Design of Chiral Single-Benzene-Based Fluorophores via Enantioselective Twofold C−H Activation: Solid-State and Circular Polarization Luminescence, and Cellular Imaging Application
Authors: Hao Erhong , Li Zhongyuan , Liu Fang , Li Heng , Guo Xing , Wu Qinghua , Jiao Lijuan
Published: October 2023

Developing chiral materials remains highly challenging due to the limited synthetic approaches to achieve enantiopure molecules with harmoniously optoelectronic properties. Herein, a class of chiral single-benzene-based fluorophores with new backbone was demonstrated via Rh-catalyzed twofold and enantioselective C–H activation with chiral transient directing group strategy. It not only approaches an efficient protocol of enantioselective twofold C–H activation in one-pot with single catalytic system, but also achieves a class of novel chiral single-benzene-based fluorophores. The new chiral fluorophores showed favorable photophysical properties, including large Stokes shifts, good fluorescence quantum yields, aggregation-induced emission (AIE) in aqueous solution, and intense emission and circularly polarized luminescence (CPL) in the solid state, indicating great potential applications as chiral fluorescent probes or optoelectronic materials. Further examination of photophysical properties and computational calculation exhibited a crucial role of the rigidly five-membered ring to provide good fluorescence quantum yields. In addition, 3al and 3aowere also employed as representatives for the lipid droplet-targeting bioimaging in living cells.
The relationship between the number of chronic diseases and health-related quality of life among middle-aged and older adults in rural areas of Yunnan province, China: moderating effect of health lifestyle
Authors: Chen Jie , Xiao Yan , Yan Chaofang , Li Xiaoju , Zhang Yafang , Chen Ying , Huang Yuan , Deng Rui
Published: October 2023

Background Individuals residing in underdeveloped rural settings may have a higher prevalence of chronic non-communicable diseases (NCDs), lower level of health-related quality of life (HRQoL), and distinct lifestyles. However, this triadic association remains inadequately studied and understood, particularly regarding the role played by health lifestyle. Yunnan province, as a typical underdeveloped region in China, is also witnessing population aging, with NCDs emerging as primary factors influencing both health status and HRQoL among middle-aged and older adults. This study aims to examine the relationship between the number of NCDs and HRQoL while exploring the potential moderating effect of health lifestyle among middle-aged and older adults residing in resource-limited areas. Methods This cross-sectional study was conducted in Yunnan province from July to December 2022. Spearman’s correlation test and Pearson’s correlation test were employed to examine the pairwise correlations among the number of NCDs, HRQoL, and health lifestyle. Hierarchical linear regression analysis was performed to explore the relationship between the number of NCDs and HRQoL, as well as investigate the potential moderating effect of health lifestyle on this relationship. Results Out of the total 2,704 participants, 57.91% presented with at least one NCD. The mean score for health lifestyle and health utility value were calculated as 11.109 and 0.944 respectively. A significant negative association was observed between the number of NCDs and health utility value, while a positive correlation was found between the number of NCDs and health lifestyle score. Health lifestyle exerted a moderating effect on the relationship between the number of NCDs and HRQoL (β = 0.006,P < 0.001), which was also observed for specific health-related behaviors such as sleep duration (β = 0.013,P < 0.001), physical examination attendance (β = 0.006,P < 0.05) and physical activity (β = 0.013,P < 0.001). Conclusions The study highlights that a healthy lifestyle exerts a crucial role in moderating the association between the number of NCDs and HRQoL. Considering the high prevalence of NCDs and substantial decline in HRQoL among middle-aged and older adults, recognizing the potential influence of a healthy lifestyle as a moderator in this relationship could be pivotal for developing effective interventions for this population, even within resource-constrained rural settings.
Determine the status of soil physiochemical properties of the Hawa Moyi micro-watershed in Western highland of Ethiopia
Authors: Regasa Abu , Deressa Sime
Published: October 2023

Information on soil is essential in sound land use planning which can enhance the production and productivity of the crops and improve the livelihood of communities. Detail assessments of the morphological, physical and chemical properties of the soil are essential in sustainable soil management. Therefore, this study was conducted to determine the status of soil physiochemical properties and identify the soil types of the Hawa-Moyi micro-watershed in the western highland of Ethiopia. Six representative soil pedons were opened along topographic positions on different land use types and described on each identified genetic horizon. The morphological properties were examined in the field while physiochemical properties were analyzed in the laboratory. Accordingly, the depth of soil was very deep for all pedons. The soil color of the study area ranged from red to very dark brown whereas the soil structure ranged from moderate granular to very strong angular blocky. Soil textural classes were clay loam to clay whereas bulk density ranged from 0.97-1.69gcm− 3in the watershed. The soil pH was rated as very strong acidic to moderately acidic whereas OM ranged from 0.22–6.23%. Total N contents ranged from 0.01–0.43% with Av. P ranged from 3.38-9.15mgkg− 1. The CEC varied from 19.42–38.5 cmolckg− 1 whereas PBS ranged from 22.47–41.82%. The soil of the study area is classified as Nitisols. Generally, the soil morphological and physiochemical properties of the study area varied along the topographic position, soil depth and land use types. In the case of its fertility status, the nutrient contents of surface soils almost ranged from low to medium with strong acid to moderate acid. Therefore, it is recommended that the soils in the study area be managed for soil fertility as well as for the removal of too many exchangeable bases and soil acidity using integrated soil fertility management methods.
The impact of continuous lenalidomide maintenance treatment on people living with Multiple Myeloma – a single-centre, qualitative evaluation study
Authors: Buck Caroline , Castillo Francisco Brenes , Bettio Elena , Land Joanne , McCourt Orla , Poole Helen , Tarling Rachel , Yong Kwee , Popat Rakesh , Lee Lydia , McMillan Annabel , Papanikolaou Xenofon , Xu Ke , Kyriakou Chara , Rabin Neil , Wechalekar Ashu , Fisher Abigail , Sive Jonathan
Published: October 2023

Purpose:
Continuous lenalidomide maintenance treatment after autologous stem cell transplantation delivers improvement in progression free and overall survival among newly diagnosed multiple myeloma patients and has been the standard of care in the UK since March 2021. However, there is scant information about its impact on patients’ day-to-day lives. This study aimed to qualitatively assess patients receiving lenalidomide treatment at a specialist cancer centre in London.
Methods:
We conducted 20 semi-structured interviews among purposively selected myeloma patients; 10 male & 10 female, median age 58 (range: 45–71) to gain insights into perspectives on lenalidomide. The median treatment duration was 11 months (range: 1–60 months). Reflexive thematic analysis was used for data analysis.
Results:
Four overarching themes were: i) Lenalidomide: understanding its role and rationale; ii) Reframing the loss of a treatment-free period to a return to normal life; iii) The reality of being on lenalidomide: balancing hopes with hurdles; iv) Gratitude and Grievances: exploring mixed perceptions of care and communication. Results will be used to enhance clinical services by tailoring communication to better meet patients' preferences when making treatment decisions.
Conclusion:
This study highlights that most patients feel gratitude for being offered continuous lenalidomide and perceive it as alleviating some fears concerning relapse. It reveals variations in side-effects on different age groups; younger patients reported no/negligible side-effects, while several older patients with comorbidities described significant symptom burden, occasionally leading to treatment discontinuation which caused distress at the perceived loss of prolonged remission. Future research should prioritise understanding the unique needs of younger patients living with multiple myeloma.
Efficacy and safety of Traditional Chinese medicine in the treatment of pulmonary nodules: protocol for a systematic review and meta-analysis
Authors: meng xingru , wen haihua , lian leshen
Published: October 2023

BACKGROUND The widespread use of chest CT has significantly enhanced the detection rate of pulmonary nodules (PN). Presently, standard treatments involve regular follow-ups and surgical interventions. Traditional Chinese medicine (TCM) represents a unique treatment method, and an increasing number of studies have shown that TCM treatment may be effective for pulmonary nodules. However, existing research lacks substantial supporting data. This study will be the first systematic review and meta-analysis that aims to evaluate the efficacy and safety of TCM treatment for pulmonary nodules.
METHODS We intend to meticulously search for randomized controlled trials (RCTs) related to Traditional Chinese Medicine (TCM) treatment for pulmonary nodules across seven comprehensive databases:PubMed,Web of Science,The Cochrane Library,Chinese National Knowledge Infrastructure (CNKI),Wanfang Database (Wangfang), Chinese Biomedical Literature Database (CBM), and Technology Periodical Database (VIP). Our primary focus will be on defining the size and characteristics of pulmonary nodules, malignancy risk score, and the overall effectiveness rate as the primary outcomes. Additionally, we will consider adverse events resulting from TCM treatment as secondary outcomes. To assess the risk of bias, we employed RevMan 5.4 software, and for conducting the meta-analysis, we utilized Stata V.15.0 software.
RESULTS From this study, we will determine the efficacy and safety of TCM in the treatment of pulmonary nodule.
CONCLUSION This study will provide preliminary evidence for the efficacy and safety of TCM in the treatment of pulmonary nodule.
Ethics and dissemination Ethical approval is not required because we will be extracting data from published articles and the findings will be published in peer-reviewed journals.
Trial registration PROSPERO registration number CRD42023465975.Registered on September 29, 2023
Identification of potentially actionable genetic variants in epithelial ovarian cancer: A retrospective cohort study
Authors: Claes Kathleen , Fieuws Charlotte , Meulen Joni Van der , Proesmans Kristiaan , De Jaeghere Emiel , Loontiens Siebe , Dorpe Jo Van , Tummers Phillipe , Denys Hannelore , de Vijver Koen Van
Published: October 2023

Ovarian cancer is the most lethal gynecologic malignancy, mainly due to late-stage diagnosis, frequent recurrences, and eventually therapy resistance. To identify potentially actionable genetic variants, sequencing data of 351 Belgian ovarian cancer patients were retrospectively captured from electronic health records. The cohort included 286 (81%) patients with high-grade serous ovarian cancer, 17 (5%) with low-grade serous ovarian cancer, and 48 (14%) with other histotypes. Firstly, an overview of the prevalence and spectrum of the BRCA1/2 variants highlighted germline variants in 4% (11/250) and somatic variants in 11% (39/348) of patients. Secondly, application of a multi-gene panel in 168 tumors revealed a total of 214 variants in 28 genes beyond BRCA1/2 with a median of 1 (IQR, 1 to 2) genetic variant per patient. The ten most often altered genes were (in descending order): TP53, BRCA1, PIK3CA, BRCA2, KRAS, TERT promotor, RB1, PIK3R1, PTEN, and ERBB2 (HER2). Of note, the genetic landscape vastly differed between the studied histotypes. Finally, using ESCAT the clinical evidence of utility for every genetic variant was scored. Only BRCA1/2 pathogenic variants were classified as tier-I. Nearly all patients (151/168; 90%) had an ESCAT
tier-II variant, most frequently in TP53 (74%), PIK3CA (9%) and KRAS (7%). In conclusion, our findings imply that although only a small proportion of genetic variants currently have direct impact on ovarian cancer treatment decisions, other variants could help to identify novel (personalized) treatment options to address the poor prognosis of ovarian cancer, particularly in rare histotypes.
AutoCleanDeepFood: Auto-cleaning and Data Balancing Transfer Learning for Regional Gastronomy Food Computing
Authors: Gilal Nauman Ullah , Qaraqe Marwa , Schneider Jens , Agus Marco
Published: October 2023

Food computing has emerged as a promising research field, employing artificial intelligence, deep learning, and data science methodologies to enhance various stages of food production pipelines. To this end, the food computing community has compiled a variety of data sets and developed various deep learning architectures to perform automatic classification. However, automated food classification presents a significant challenge, particularly when it comes to local and regional cuisines, which are often underrepresented in available public domain data sets. Nevertheless, obtaining high-quality, well-labeled, and well-balanced real-world labeled images is a challenging task since the manual curation of data requires significant human effort and is time-consuming. In contrast, the web has a potentially unlimited source of food data but tapping into this resource has a good chance of corrupted and wrongly labeled images. In addition, the uneven distribution among food categories may lead to data imbalance problems. All these issues make it challenging to create clean data sets for food from web data. To address this issue, we present AutoCleanDeepFood, a novel end-to-end food computing framework for regional gastronomy that contains the following components: (i) a fully automated pre-processing pipeline for custom data sets creation related to specific regional gastronomy, (ii) a transfer learning-based training paradigm to filter out noisy labels through loss ranking, incorporating a Russian Roulette probabilistic approach to mitigate data imbalance problems, and (iii) a method for deploying the resulting model on smartphones for real-time inferences. We assess the performance of our framework on a novel, web-collected data set and the ETH Food-101 real-world noisy data set. We demonstrate the filtering capabilities of our proposed method through embedding visualization of the feature space using the t-SNE dimension reduction scheme. Our filtering scheme is efficient and effectively improves accuracy in all cases, boosting performance by 0.1% for curated data sets and 0.61% for noisy data set like ETH Food-101. Additionally, we introduce MENA-150, a large-scale image data set that we created from scratch with the proposed framework. MENA-150 features 150 unique traditional dishes from the Middle East and North Africa (MENA) region.
My virtual home: Needs of patients in palliative cancer care and content effects of individualized virtual reality – a mixed methods study protocol
Authors: Gerlach Christina , Greinacher Anja , Alt-Epping Bernd , Wrzus Cornelia
Published: October 2023

Background: The desire to be at home is one of the most important needs of patients with advanced, incurable cancers. However, palliative cancer patients may require inpatient hospital care for medical reasons. Virtual reality (VR) could provide an approximation to the individuals’ home environment. Methods: The project consists of 3 parts. All parts are supported by the patient advisory board. In the 1st part of the project, we interview patients, relatives, and the patient advisory board about their wishes and concerns regarding the project. In the 2nd part of the project, patients are offered to view VR videos of their choice (their home, relatives, others if applicable). Effects and side-effects of the intervention are assessed with validated instruments (MIDOS, MDBF, SSQ, SPES). Diagnosis, treatment adherence, medication, and vegetative functionality is determined from the medical records of the patients. In the 3rd part of the project, the results of the study will be discussed with patients, relatives, health care professionals and the patient advisory board regarding implementation.
Discussion: This study is the first to investigate whether individualized VR videos have additional benefits over generic VR nature videos on symptom relief, well-being, treatment satisfaction, and adherence in patients with palliative cancer care. A strength of the study is that we can incorporate the results of each part of the project into the subsequent project parts. However, the generalizability might be limited as this is a single-centred study.
Trial registration: Registered at German Clinical Trials Register (Deutsches Register Klinischer Studien; DRKS); registration number: DRKS00032172; registration date: 11/07/2023
Dynamics and concordance alterations of regional brain function indices in vestibular migraine: a restingstate fMRI study
Authors: Xiong Xing , Dai Lingling , Chen Wen , Lu Jiajie , Hu Chunhong , Zhao Hongru , Ke Jun
Published: October 2023

Background Prior MRI studies on vestibular migraine (VM) have revealed abnormalities in static regional intrinsic brain activity (iBA) and dynamic functional connectivity between brain regions or networks. However, the temporal variation and concordance of regional iBA measures remain to be explored.
Methods 57 VM patients during the interictal period were compared to 88 healthy controls (HC) in this resting-state functional magnetic resonance imaging (fMRI) study. The dynamics and concordance of regional iBA indices, including amplitude of low-frequency fluctuations (ALFF) and regional homogeneity (ReHo), were examined by utilizing sliding time-window analysis. Partial correlation analyses were performed between clinical parameters and resting-state fMRI indices in brain areas showing significant group differences.
Results The VM group showed increased ALFF and ReHo dynamics, as well as increased temporal concordance between ALFF and ReHo in the bilateral paracentral lobule and supplementary motor area relative to the HC group. We also found decreased ReHo dynamics in the right temporal pole, and decreased ALFF dynamics in the right cerebellum posterior lobe, bilateral angular gyrus and middle occipital gyrus (MOG) in the VM group compared with the HC group. Moreover, a positive correlation was observed between ALFF dynamics in the left MOG and vertigo disease duration across all VM patients.
Conclusion Temporal dynamics and concordance of regional iBA indices were altered in the motor cortex, cerebellum, occipital and temporoparietal cortex, which may contribute to disrupted multisensory processing and vestibular control in patients with VM. ALFF dynamics in the left MOG may be useful biomarker for evaluating vertigo burden in this disorder.
A Deep Learning approach for Transportation Mode Identification using a transformation of Global Positioning System trajectory data into image representations
Authors: Ribeiro Ricardo , Trifan Alina , Neves António J. R.
Published: October 2023

Global Positioning System data plays a crucial role in comprehending an individual's life due to its ability to provide geographic positions and timestamps. However, the large amount of spatio-temporal data generated, and the distinct spatial characteristics exhibited by different modes, poses challenges for learning transportation modes from the Global Positioning System trajectories. This paper introduces a novel approach for transportation mode identification by transforming Global Positioning System trajectory data into image representations and employing these images to train a neural network based on Vision Transformers architectures. The proposed method avoids segmenting or changing trajectories and directly extracts a set of features from the Global Positioning System trajectories. By mapping the trajectory features into pixel location generated using a dimensionality reduction technique, images are created for training a deep learning model to predict five transport modes. Experimental results demonstrate the approach effectiveness, achieving a state-of-the-art accuracy of 92.96\% on the Microsoft GeoLife dataset. Moreover, it highlights the differences in the experiments conducted in each study. Additionally, a comparative analysis was performed regarding our proposal, contrasting a machine learning approach and other neural network architectures with this approach. The proposed method offers accurate and reliable transport mode detection applicable in real-world scenarios, facilitating a comprehensive understanding of individual's mobility.
Enhancing Sentiment Analysis via Fusion of Multiple Embeddings using Attention Encoder with LSTM
Authors: Soni Jitendra , Mathur Kirti
Published: October 2023

Different embeddings capture various linguistic aspects, such as syntactic, semantic, and contextual information. Taking into account the diverse linguistic facets we propose a novel hybrid model. This model hinges on the amalgamation of multiple embeddings through an attention encoder, subsequently channeled into an LSTM framework for sentiment classification. Our approach entails the fusion of Paragraph2vec, ELMo, and BERT embeddings to extract contextual information, while FastText is adeptly employed to capture syntactic characteristics. Subsequently these embeddings were fused with the embeddings obtained from the attention encoder which forms the final embeddings. LSTM model is used for predicting the final classification. We conducted experiments utilizing both the Twitter Sentiment140 and Twitter US Airline Sentiment datasets. Our fusion model's performance was evaluated and compared against established models such as LSTM, Bi-directional LSTM, ,BERT and Att-Coder. The test results clearly demonstrate that our approach surpasses the baseline models in terms of performance.
Perspectives of primary care physicians in Spain on malaria: a cross-sectional survey and retrospective review of cases
Authors: Linares-Rufo Manuel , Bermudez-Marval Harold , García-Bertolín Carlos , Santos-Galilea Joaquín , Vázquez Javier Balsa , Pérez-Tanoira Ramón , Santos-Larrégola Laura , Cuadros-González Juan , Rojo-Marcos Gerardo , Ramos-Rincón José-Manuel
Published: October 2023

Background In Spain, the risk of imported malaria has increased in recent years due to the rise in international travel and migration. Little is known about the knowledge, information sources, clinical practice, and specific needs of primary care physicians (PCPs) concerning malaria despite the pivotal role played by these professionals in managing the health of tourists. The objective of this study was to assess the knowledge, attitudes, and practices of PCPs in Spain regarding malaria.
Methods This research analyzes data from (1) a cross-sectional nationwide survey assessing the knowledge and attitudes of PCPs regarding malaria and (2) a retrospective review of 373 malaria cases appearing in primary care medical records (PCMRs) in the Madrid area over the past 15 years to determine how cases were documented, managed, or characterized in the primary care setting.
Results The survey findings reveal a modest level of self-perceived familiarity with malaria (221/360, 57.6%), even though 32.8% of the practitioners reported having delivered care for confirmed or suspected cases of the disease. Ten percent of the survey participants did not know the name of the mosquito that transmits malaria, and only 40.7% would promptly request malaria testing for a traveler with symptoms after a trip to an endemic area. Responses provided by younger PCPs varied to a greater extent than those of their more experienced colleagues regarding prevention practices and patient management. A review of PCMRs showed that only 65% of all patients were recorded as such. Among those registered, only 40.3% had a documented malaria episode, and of those, only 16.6% received proper follow-up. Only 23.7% of the patients with a PCMR had a record that specifically indicated travel to an endemic country or travel classified as visiting friends and relatives (VFR).
Conclusions The findings of this study underscore the critical role of PCPs in the field of travel medicine, particularly given the increase in imported malaria cases. These results highlight the need for targeted training in travel medicine and the need to ensure optimal patient education in care settings.
Modern forms of iodine-containing food components
Authors: Dydykin A. S. , Zubarev Yu. N. , Logunova E. I. , Kuzlyakina Yu. A.
Published: October 2023

The article presents the statistics of iodine deficiency disorders and the possible causes of their occurrence. The methods of iodine deficiency correction on the basis of state programs are reviewed. The recommendations from the World Health Organization on the amount of iodine added to iodized salt are given. A review of scientific databases on the topic of iodine-containing food components of various nature and their classification are given based on the form of the components (organic or inorganic). The analysis of iodine preservation in foods incorporating iodine-containing components under various conditions of technological processing and storage has been carried out.
Investigation of the chemical composition, physicochemical properties, and microstructure of meat patties with amaranth flour
Authors: Suychinov A. K. , Zhumanova G. T. , Mironova I. V. , Akhmadullina E. T. , Kadirov N. N. , Galiyeva Z. A. , Neverova O. V.
Published: October 2023

This study aimed to investigate the effect of adding amaranth flour to meat patties on their chemical composition. Four different variations of meat patties were prepared, with amaranth flour added at concentrations of 5%, 10%, and 15% in place of beef. The control sample was prepared without any addition. The results of the study showed that the addition of amaranth flour led to a significant decrease in the moisture content of the meat patties, while the proportions of carbohydrates, fat, and ash increased. Specifically, the patties with the highest concentration of amaranth flour (15%) had the highest proportions of carbohydrates and fat with the lowest proportion of moisture. The control sample had the highest moisture content and the lowest proportion of carbohydrates, fat, and ash. The addition of amaranth flour increased the water-holding capacity of the meat patties, with the highest increase observed in the sample with 15% amaranth flour (82.21%). The overall score of sensory evaluation of the meat patties did not significantly decrease with the addition of up to 10% amaranth flour, according to the sensory evaluation. The study provides evidence that up to 10% amaranth flour can be used as a substitute for beef in meat patties, which can lead to an increase in the fat and carbohydrate content and mineral composition and improvement of the water-holding capacity of the final product.
The effect of magnetic and electric fields on the processes of food freezing
Authors: Belozerov G. A. , Belozerov A. G. , Konnov A. V.
Published: October 2023

The article summarizes the results of studies based on scientific publications on the effect of magnetic fields (MF) and electric fields (EF) on the kinetics of freezing processes applied onto biological tissue and on their properties. The processes of freezing food media on installations equipped with the Cells Alive System (CAS) magnetic system manufactured by ABI Co., Ltd., Japan are considered in this article. It is shown that the majority of researchers did not confirm the benefits claimed by the CAS system developers in comparison with the processes of fast freezing in the chambers without the magnetic field. In the case of using the alternating magnetic fields (AMF) with high field induction values, the effect is more pronounced. The application of strong static or alternating EF contributes to the creation of a fine-grained structure of ice, reduces the freezing duration and decreases mass loss during the food thawing.
Solving 3d gravity with Virasoro TQFT
Authors: Collier Scott , Eberhardt Lorenz , Zhang Mengyang
Published: October 2023

We propose a precise reformulation of 3d quantum gravity with negative cosmological constant in terms of a topological quantum field theory based on the quantization of the Teichmüller space of Riemann surfaces that we refer to as “Virasoro TQFT”. This TQFT is similar, but importantly not equivalent, to SL(2, \mathbb{R}ℝ) Chern-Simons theory. This sharpens the folklore that 3d gravity is related to SL(2, \mathbb{R}ℝ) Chern-Simons theory into a precise correspondence, and resolves some well-known issues with this lore at the quantum level. Our proposal is computationally very useful and provides a powerful tool for the further study of 3d gravity. In particular, we explain how together with standard TQFT surgery techniques this leads to a fully algorithmic procedure for the computation of the gravity partition function on a fixed topology exactly in the central charge. Mathematically, the relation leads to many nontrivial conjectures for hyperbolic 3-manifolds, Virasoro conformal blocks and crossing kernels.
A Chern-Simons theory for dipole symmetry
Authors: Huang Xiaoyang
Published: October 2023

We present effective field theories for dipole symmetric topological matters that can be described by the Chern-Simons theory. Unlike most studies using higher-rank gauge theory, we develop a framework with both U(1)U(1) and dipole gauge fields. As a result, only the highest multipole symmetry can support the ’t Hooft anomaly. We show that with appropriate point group symmetries, the dipolar Chern-Simons theory can exist in any dimension and, moreover, the bulk-edge correspondence can depend on the boundary. As two applications, we draw an analogy between the dipole anomaly and the torsional anomaly and generalize particle-vortex duality to dipole phase transitions. All of the above are in the flat spacetime limit, but our framework is able to systematically couple dipole symmetry to curved spacetime. Based on that, we give a proposal about anomalous dipole hydrodynamics. Moreover, we show that the fracton-elasticity duality arises naturally from a non-abelian Chern-Simons theory in 3D.
Major food-borne zoonotic bacterial pathogens of livestock origin: Review
Authors: Zenu Fuad , Bekele Tesfaye
Published: October 2023

Animal food-borne microbes are pathogens that jeopardize food safety and cause illness in humans via natural infection or contamination. Most of those microbes are bacteria that have considerable impacts on public health. Their survival and pathogenicity are due to toxin production, biofilm development, spore formation, disinfection resistance, and other traits. However, detailed information about them is scattered across scientific literature. We aimed to compile information about major zoonotic bacteria linked with human food of livestock origin and describe their typical features, transmission modes, detection, and preventative approaches. In particular, we addressed the following pathogens that cause food-borne disease worldwide: Campylobacter, Salmonella, Listeria, Staphylococcus, Brucella, Clostridium, Mycobacterium, Colibacilus, and some others. Many of those bacteria have substantial reservoirs in food animals, and food products of animal origin are the primary vehicles of their transmission. Human beings become affected by food-borne zoonotic bacteria if they consume raw animal products or foods produced by using unstandardized slaughtering methods or unsanitary preparation and handling procedures. These zoonotic bacteria and their toxins can be detected in food by culturing, serological, and molecular diagnostic methods. They are effectively controlled and prevented by good hygiene, good management practices, cooking, and pasteurization protocols. In addition, there is a need for a centralized surveillance and monitoring system, as well as higher awareness in society of the occurrence, prevention, and control of bacterial pathogens related to food animals.
The Influence of Information Types and Search Intention in Using Branded Or Generic Search Query
Authors: Pinem Ave , Handayani Putu Wuri , Winona Clarissa Martalin
Published: October 2023

This study aims to analyze the effect of each type of information and search intention on the use of branded or generic search queries on search engines. This is done because of the emergence of the phenomenon of information overload or explosion of information. The types of tourism information studied are transportation, accommodation, restaurants, shopping places, and tourist attractions with two types of intention, namely purchase intention and intention to search. This study used a quantitative approach by distributing online questionnaires to users who had searched using a search engine and managed to collect 1,256 respondents. Data were analyzed using binary logistic regression. We found that intention influences the use of branded or generic search queries and several types of information influence the use of search queries. Transportation and shopping information could influence users in choosing to use generic or branded search queries.
Research on concept regulation and typification of licensed magazines
Authors:   The Korean Publishing Science Society, Kwon Oh-Hyun , Lee Yong Jun , Cho Hang Min , Kim Chan-Won
Published: October 2023

This study aims to define and categorize the concept of independent magazines in detail. To this end, in-depth interviews were conducted with independent magazine publishers, and 300 cases of independent magazines that were in currently circulation or closed were analyzed. First, the research results cannot single-concept independent magazines with complex characteristics, but the concept of independent magazines can be explained cross-sectionally by subject, publisher type, publishing cycle, content content, production method, advertisement, circulation, distribution method, and magazine edition. Second, the types of independent magazines can be largely divided into publishers and topics. The publisher could be categorized into one person, group, minority group, magazine, publication, and complex, and the subject type could be subdivided into total class, art, literature, photography, design, illustration, cartoon, lifestyle, social culture, and subculture. Finally, it was revealed that independent magazine publishers are publishing magazines in a complex trend. The significance of this study is to reveal the empirical concepts and types of independent magazines that have not yet been conducted in Korea, and to present related basic data and evidence.
Research on the Future Model of Literature Utilizing ICT : Focusing on Case Studies and Scenario Methods
Authors:   The Korean Publishing Science Society, Kong Byoung Hun
Published: October 2023

This study analyzed the main factors affecting literature and the literary ecosystem in the ICT environment and what kind of future model of literature will be formed. As a result of the analysis, the literary ecosystem forms a future model in which 'literary content as IP' is traded and distributed based on platforms in a rapidly changing technological and policy environment in which literary content creators and producers and literary content users interact through ICT factors such as artificial intelligence, VR and AR, blockchain, digital publishing, and platforms. In this model, authors and communities of authors, creative users, copyright agencies, and artificial intelligence agencies are the agents of creation and production. The areas of 'creation/production' and 'reading/use' will be converged based on platforms, and the phenomenon of mutual conversion will become commonplace. Literature will evolve into an IP-centered activity model that creates transmedia content that crosses media and genres, centered on technology-based platforms.
The Impact of ABCB1 SNPs on Tacrolimus Pharmacokinetics in Liver or Kidney
Transplant Recipients: A Meta-analysis
Authors: Li Ze , Wang Xiaozhen , Li Dandan , Cheng Sheng , Dong Yiwen , Yang Hongge , Li Xingang
Published: October 2023

Purpose:

We aimed to investigate the association between ATP Binding Cassette Subfamily B
Member 1 (ABCB1) single nucleotide polymorphisms (SNPs) and the pharmacokinetics of tacrolimus.

Methods:

A search was conducted in Cochrane Central Register of Controlled Trials (CENTRAL), Web of
Science (SCI), MEDLINE, and Embase from inception to November 2022. Outcomes included weightadjusted
daily dose (DD) and dose-adjusted trough concentration (C0/Dose).

Results:

A total of 1059 liver or kidney transplant recipients from 14 publications were included. For adult
liver transplantation recipients, DD of ABCB1 3435C>T CC carriers was 0.03 mg/kg/day (WMD = 0.03, 95%
CI: 0.01 to 0.05, I2 = 0%) higher than ABCB1 3435C>T T carriers at post-transplantation ≤ 7 days; C0/dose of
ABCB1 3435C>T CC carriers were 31.88 (WMD = -31.88, 95% CI: -62.32 to -1.45, I2 = 83.5%) or 34.61
(ng/ml)/(mg/kg/day) (WMD = -34.61, 95% CI: -65.26 to -3.97, I2 = 55.3%) lower than ABCB1 3435C>T T
carriers at post-transplantation ≤ 7 or 14 days, respectively. No difference in C0/dose was observed for
ABCB1 2677G>T/A or ABCB1 1236C>T SNPs in both liver and kidney transplant recipients.

Conclusion:

ABCB1 3435C>T SNP might have a potential impact on tacrolimus pharmacokinetics in the early
stage after liver transplantation, indicating the probability of individualized immunosuppressive therapy
based on genetic polymorphism. Given some limitations, further well-designed prospective studies are warranted
to validate these conclusions.
The Potential of Cannabidiol for Acute Respiratory Distress Syndrome in
COVID-19
Authors: Azimi Saeid , Saghafi Fatemeh , Mohammadi Mohammad Hossein , Moghimi Mohammad Hossein , Akhavan Seyed Ali , Khataminia Masoud , Shirvani Maria , Sohrevardi Seyed Mojtaba , Jamialahmadi Tannaz , Sahebnasagh Adeleh , Sahebkar Amirhossein
Published: October 2023

COVID-19 disease manifests itself in a wide range of signs and symptoms, beginning with mild
symptoms, such as fever, cough, and dyspnea, progressing to acute respiratory distress syndrome (ARDS) and
death in some cases. The cytokine storm, or an excess of cytokines released locally, is assumed to be the primary
cause of ARDS and mortality in COVID-19 patients. To enhance the survival rate of COVID-19 patients,
early management of the cytokine storm with immunomodulators is crucial. Although the effectiveness
of some immunosuppressants, such as corticosteroids and tocilizumab, has been studied in clinical trials, the
administration of these drugs should be exercised cautiously. Cannabidiol (CBD) is a non-psychotropic phytocannabinoid
from Cannabis sativa extracts with anti-inflammatory properties. This review is intended to discuss
the possible utility of CBD for the management of COVID-19 patients, particularly those with ARDS.
A Comprehensive Review on Imperative Role of Ionic Liquids in Pharmaceutical
Sciences
Authors: Uniyal Prerna , Das Shibam , Panwar Surbhi , Kukreti Neelima , Nainwal Pankaj , Bhatia Rohit
Published: October 2023

Ionic liquids (ILs) are poorly-coordinated ionic salts that can exist as a liquid at room temperatures
(or <100 °C). ILs are also referred to as "designer solvents" because so many of them have
been created to solve particular synthetic issues. ILs are regarded as "green solvents" because they
have several distinctive qualities, including better ionic conduction, recyclability, improved solvation
ability, low volatility, and thermal stability. These have been at the forefront of the most innovative
fields of science and technology during the past few years. ILs may be employed in new drug formulation
development and drug design in the field of pharmacy for various functions such as improvement
of solubility, targeted drug delivery, stabilizer, permeability enhancer, or improvement of bioavailability
in the development of pharmaceutical or vaccine dosage formulations. Ionic liquids have
become a key component in various areas such as synthetic and catalytic chemistry, extraction, analytics,
biotechnology, etc., due to their superior abilities along with highly modifiable potential. This
study concentrates on the usage of ILs in various pharmaceutical applications enlisting their numerous
purposes from the delivery of drugs to pharmaceutical synthesis. To better comprehend cuttingedge
technologies in IL-based drug delivery systems, highly focused mechanistic studies regarding
the synthesis/preparation of ILs and their biocompatibility along with the ecotoxicological and biological
effects need to be studied. The use of IL techniques can address key issues regarding pharmaceutical
preparations such as lower solubility and bioavailability which plays a key role in the lack of
effectiveness of significant commercially available drugs.