bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk-adapted combined therapy with arsenic trioxide and all-trans-retinoic acid for de novo acute promyelocytic leuкaemia
Authors: Troitskaya V. V. , Parovichnikova E. N. , Semenova A. A. , Fidarova Z. T. , Sokolov A. N. , Galstyan G. M. , Spirin M. V. , Gribanova E. O. , Sysoeva E. P. , Dvirnyk V. N. , Naumova I. N. , Obukhova T. N. , Glinshchikova O. A. , Klyasova G. A. , Chabaeva Yu. A. , Kulikov S. M. , Savchenko V. G.
Published: September 2021

Introduction. Non-chemotherapy for acute promyelocytic leukaemia (APL) with a combination of all-trans-retinoic acid (ATRA) and arsenic trioxide (ATO) provides for a high patient survival rate at lesser toxicity as effectively or superior to standard chemotherapy programmes.

Aim — assessment of the ATO–ATRA risk-adapted exposure protocol in management of de novo acute promyelocytic leucaemia.

Materials and methods. A prospective study included 51 primary APL patients aged 18–76 years. The program included remission induction (ATO 0.15 mg/kg intravenously, ATRA 45 mg/m2 orally) for 30–60 days in a low-risk (until remission) and 60 days — in a high-risk cohort that had idarubicin therapy added on days 2 and 4. Remission consolidation was attained with four (low-risk) or five (high-risk) courses. Minimal residual disease was monitored with real-time PCR at all phases.

Results. The high-risk cohort was assigned 15 (29.4 %), the low-risk cohort — 36 (70.6 %) patients. Therapy induction till APL morphological remission was performed in 48/51 (94 %) patients. Molecular APL remission was achieved in 47 (92 %) patients, 100 % in the low-risk and 80 % in high-risk cohort. Early mortality was 6 % (n = 3), death in remission — 2 % (n = 1). Differentiation syndrome (DS) occurred in 16 (31.7 %) patients, more frequently in the high-risk vs. low-risk cohort (53.3 % and 22.2 %, respectively, p = 0.05; odds ratio 4.0 [1.1–14.4]). DS developed on days 1–20 (3 days median) of therapy. DS risk factors: a high-risk status, haemorrhagic syndrome and infection at the disease onset. A median follow-up time in survivors was 12.9 months (2.5–34.3), a six-month overall survival — 92 % (95 % CI: 85–100 %). A six-month overall survival was 100 and 73 % in the low- and high-risk cohorts, respectively (95 % CI: 54–100 %, p = 0.001). APL relapse not registered, 47 (92 %) patients survived and achieved the first molecular remission.

Conclusion. A differentiated risk-adapted approach to APL therapy with cytostatic treatment added in high-risk patients only provided for a 100 % molecular remission and relapse-free survival. Therapy failures (early mortality and death in remission) affected high-risk patients due to a severe individual condition at the time of APL diagnosis.
Minimal residual disease and b-cell subpopulation monitoring in acute b-lymphoblastic leukaemia patients treated on rall-2016 protocol
Authors: Galtseva I. V. , Davydova Y. O. , Parovichnikova E. N. , Gavrilina O. A. , Troitskaya V. V. , Kapranov N. M. , Nikiforova K. A. , Isinova G. A. , Zarubina K. I. , Sokolov A. N. , Savchenko V. G.
Published: September 2021

Introduction. The Russian multicentre trial on treatment of Acute Lymphoblastic Leukaemia (ALL) in adults (RALL-2016) regulates a centralised detection of minimal residual disease (MRD) on days 70 (end of induction II), 133 (end of consolidation III) and 190 (end of consolidation V).

Aim — the assessment of tumour cell clearance and normal B-cell precursor, mature B-cell and plasma cell dynamics.

Materials and methods. The study period of December 2016 — August 2019 covered 59 B-ALL patients; the control cohort included four allogeneic blood stem cell donors. The MRD detection was performed with bone marrow samples in flow cytometry.

Results. The patient majority have reached MRD-negativity at control timepoints, 60.4, 75.6 and 91.2% on days 70, 133 and 190, respectively. No correlation was observed between MRD values and tumour cell immunophenotype. B-cell precursors were undetected in 54.4, 38.8 and 59.4% patients on days 70, 133 and 190, respectively. Mature B-cells were fewer compared to donors’ on days 133 and 190. The relative plasma cell count did not differ significantly over therapy and between patients and donors.

Conclusion. The RALL-2016 protocol facilitates MRD-negativity in the patient majority despite reduced cytostatic intensity.
Significance of TPMT and NUDT15 variants in 6-mercaptopurine metabolism in acute lymphoblastic leukaemia/lymphoma patients
Authors: Kotova E. S. , Gavrilina O. A. , Sudarikov A. B.
Published: September 2021

Introduction. Among main curative substances in acute lymphoblastic leukaemia/lymphoma (ALL/LBL) is 6-mercaptopurine (6-MP). However, the severity of adverse reactions (ADRs) to this drug varies considerably among patients, which is sometimes conditioned by individual single nucleotide polymorphisms in key 6-MP metabolism enzyme genes.

Aim — a literature review on the role of TPMT and NUDT15 gene variants in 6-MP metabolism in ALL/LBL.

Main findings. The TPMT and NUDT15 genes encode enzymes mediating key steps of the 6-MP metabolism. The metabolites determine the 6-MP therapeutic and toxic properties, with ADRs emerging when their concentrations alter. A number of TPMT and NUDT15 single nucleotide polymorphisms are associated with varied activities of the encoded enzymes, and their allelic combinations condition functional and non-functional phenotypes. Non-functional variant carriers more likely develop toxicity on 6-MP treatment compared to functional phenotypes. Non-functional TPMT/NUDT15 carriers should have the 6-MP dosage reduced to minimise emerging ADRs.
Environmental Effects on Squatter Settlement: A Case of Alagbede Village, Lagos, Nigeria
Authors: Adeoye D. O
Published: September 2021

Healthy housing is a function of provision of adequate physical, social and mental conditions for healthy environment. It is a function of both intrinsic and extrinsic attributes of housing that can influence human health. Environment and human activities are omen to development. The effects are manifested in generating land use problems such as congestion, sprawl development, incompatible land uses, building alterations and change of uses, the menace of temporary structures, alteration of land use functions, conversion of open and future spaces, and land degradation. Alagbede village is one of the areas that require such development drive. The study is required to facilitate this need. This research effort is to examine the environmental effect of squatter settlements in Alagbede village, Ikeja, Lagos State Nigeria. The paper examined housing conditions in terms of privacy, adequate space, physical accessibility, adequate security, security of tenure, structural stability and durability, adequate lighting, and ventilation, and basic infrastructure (such as water supply, sanitation, and waste management facilities including suitable environmental quality and health related factors and its influence on the residents of Alagbede area, Ikeja Lagos State. Approach includes the development of database and choice of appropriate data source (primary and secondary data sources). From the methodology, there were questionnaire administration, direct interview of respondents, collection and updating of the base maps, and the use of necessary field instrument for the study. The data gathered were analysed using descriptive method. The end result has revealed a number of environmental problems due to the existence of these settlements (Alagbede village). These problems are poor drainage system, noise pollution, illegal refuse dump sites, slum situations etc. Appropriate recommendations in form of short time and long term solutions were suggested to conclude the research work.
Comparative Study of Mechanical and Microstructural Properties of Interlocking Concrete Blocks Reinforced with Chicken Feather Fiber and blend of Chicken Feather Fiber/Synthetic Hair Fibers
Authors: Adetola S. O. , Akinyemi S. A.
Published: September 2021

Concrete reinforcement with fibers is undergoing findings in order to manufacture concrete with low cost but improve mechanical and microstructural properties. Chicken feather fiber(CFF) possesses characteristics, which can improve the mechanical and microstructural properties of the concrete. Concrete is a brittle material with no tension. In this study, samples A (control sample), B1 and C1 constitute of 0%, 1% and 3% by weight of CFF while B and C constitute of 0.5% and 1.5% equal proportion of CFF and Synthetic hair fiber(SHF) respectively. Concrete with CFF and CFF/SHF composites were tested to determine water absorption (WA), thickness swelling (TS), compressive strength (CS) and splitting tensile strength (STS) between 7 to 28 days of curing. Results of WA of concrete increased after 28 days to 10.01%, 12.52% and 23.11% for samples A, B1, C1 and 11.83% and 17.67% for samples B and C respectively. Similarly, TS increased after 28 days to 0.13%, 0.22% and 0.32% for samples A, B1and C1 and for samples B and C it remains stable at 0.25%., respectively. CS of samples A and B1 increased with curing days to values of 20.66 MPa and 9.36 MPa, respectively. However, for samples C1, B and C it decreased to 3.74 MPa, 9.98 MPa and 4.29 MPa. STS of A, B1 and C1 increased with curing days with values of 13.94 MPa, 8.91 MPa and 2.26 MPa respectively while samples B and C decreased with curing days with values of 5.43 MPa and 2.39 MPa respectively, after 7 days. Results of SEM deduced that CFF improves the ductility of ICBs but increased in the proportion resulted in reduction of the STS of the concrete. Similarly, SHF offers higher CS but also serves the purpose of reduction in micro cracking and increasing structural stability.
Sustainable Facilities Management for Smart Buildings: A Case Study of the Heritage Place, Lagos
Authors: Faremi J. O.
Published: September 2021

A recent development within the metropolis of Lagos State, Nigeria is the emergence of smart buildings aimed at providing safer, more secure, productive and comfortable business environment. A major challenge to the sustenance of such edifice is the delivery of strategic facilities management services to maximise the building’s efficiency and achieve expected return on investment. This study investigates sustainable facilities management practices in smart buildings using the Heritage Place as a case study. A cross-sectional survey was conducted on 19 facilities management personnel and 68 users of the facility. chart, mean score and Spearman’s Correlation were used as the descriptive and inferential statistical tools, respectively. The results show the most frequently practiced sustainable facilities management practice to include: compliance to the preventive maintenance schedules for Heating Ventilation and Air Conditioning (HVAC) systems and prompt response to repairs and corrective work activities in the facility with mean scores of 5.00 and 4.90, respectively. The results further show that the facility users were dissatisfied with the level of implementation of sustainable facilities management practices, except in integrated pest management and optimised waste management where marginal satisfaction were recorded, respectively. The study recommends a sustained effort by smart buildings stakeholders at implementing sustainable facilities management practices in order to significantly and continually improve operations and maintenance activities in the buildings. And that the efforts of facilities managers for smart buildings should be geared at the delivery of strategic facilities management services that meet the expectations of users of the facilities.
Multi-UE Multi-AP Beam Alignment in User-Centric Cell-Free Massive MIMO Systems Operating at mmWave
Authors: Buzzi Stefano , D'Andrea Carmen , Fresia Maria , Wu Xiaofeng
Published: September 2021

This paper considers the problem of beam alignment in a cell-free massive MIMO deployment with multiple access points (APs) and multiple user equipments (UEs) simultaneously operating in the same millimeter wave frequency band. Assuming the availability of a control channel at sub-6 GHz frequencies, a protocol is developed that permits estimating, for each UE, the strongest propagation path from each of the surrounding APs, and to perform user-centric association between the UEs and the APs. Estimation of the strongest paths from nearby APs is realized at the UE in a one-phase procedure, during which all the APs simultaneously transmit on pseudo-randomly selected channels with pseudo-random transmit beamformers. An algorithm for orthogonal channels assignment to the APs is also proposed, with the aim of minimizing the mutual interference between APs that transmit on the same channels. The performance of the proposed strategy is evaluated both in terms of probability of correct detection of the directions of arrival and of departure associated to the strongest beam from nearby APs, and in terms of downlink and uplink signal-to-interference-plus-noise ratio. Numerical results show that the proposed approach is effective and capable of efficiently realizing beam alignment in a multi-UE multi-AP wireless scenario.
Derecho penal del enemigo
Authors: Cruz López Midzon Rigoberto
Published: September 2021

OBJETIVO: establecer si las normativas implementadas con el tiempo han permitido observar cambios profundos en el actuar de los individuos y que esta teoría no solo permita incrementar penas, quedando a la par de muchas otras que lo único que conllevan es la creación de más cuerpos normativos y la creación de más figuras delictivas. MÉTODO: analítico, sintético, inductivo, bibliográfico, jurídicos, documentales y de observación. RESULTADO: el Derecho Penal, es un derecho que permitió regular las conductas de los seres humanos dentro de una sociedad, restringiendo determinadas garantías constitucionales y  derechos con la imposición de una pena contundente, actos que vienen regulados desde épocas antiguas cuando a los delincuentes se les imponían sanciones severas, que y su  castigo consistía en quitarles la vida, sin embargo este derecho ha venido evolucionando desde con el pasar del tiempo, surgiendo diferentes teorías y ponientes, pero en la época actual se le ha dado mayor auge a una supuesta Teoría propuesta por el Filósofo Gunter Jakobs en lo que se refiere al Derecho Penal de Enemigo, que con la realización de actos terroristas en todo el mundo, da lugar que este gran filósofo forme una clasificación sobre los individuos en dos grupos siendo estos: personas y enemigos. En la antigüedad se consideraba a las personas enemigas, como un mal grave, comparado con un tumor canceroso, al cual había que eliminar de un cuerpo, es decir de la sociedad, es por esa razón que se proponen métodos de castigo para las personas que se consideren enemigos, a los que han sido castigados y no cumplen se les proponen que sean expulsados de las ciudades y en otros casos que se le de muerte como si fuera un incurable. CONCLUSIÓN: el derecho penal del enemigo es una manifestación empírica de la sociedad que su principal exponente observo en la sociedad a grupos delincuenciales capaces de conmover las bases fundamentales de la sociedad como lo son el bien común y la seguridad ciudadana, siendo necesaria la implementación de normas penales especiales con sanciones contundentes, para poder contrarrestar la delincuencia organizada.
Universidad autónoma venezolana: expectativas de las autoridades rectorales
Authors: Caira Tovar Norma M. , Sánchez Morles José G.
Published: September 2021

La tendencia de este milenio a observar la realidad desde un enfoque integral y humanista no ha obviado la actualidad universitaria, la cual ha manifestado limitaciones en su desenvolvimiento institucional. Este escenario conllevó a realizar un estudio que describiera las expectativas sobre la universidad autónoma venezolana desde la perspectiva de su gerencia, considerando para ello a las autoridades rectorales elegidas para el período 2008-2012 y que se han mantenido en sus cargos por más de diez años. La investigación fue enmarcada en el paradigma interpretativo, siguiendo los pasos del enfoque cualitativo, el método hermenéutico y el análisis de contenido, a través del uso de documentos institucionales de acceso público, emitidos por las autoridades de las universidades autónomas nacionales durante eventos realizados en fechas de relevancia (actos de grado, aniversarios institucionales y consejos universitarios extraordinarios), así como referencias teóricas de Albornoz (2013), Bolman y Deal (2017), Chiavenato (2017), Lussier y Achua (2016), Newstrom (2011), Robbins y Coulter (2018). Del análisis realizado emergieron las categorías construcción del futuro, incertidumbre y proyecto de país. Para la fiabilidad del estudio se realizó una triangulación de datos y de teoría (se contrastaron los contenidos de los documentos entre sí y con los referentes teóricos). Los hallazgos revelan que para las autoridades rectorales las expectativas constituyen un estado de esperanza, el cual requiere de unidad para encaminar esfuerzos en el proceso de recuperación de la universidad y de la reconstrucción del país. Se concluye que, desde la perspectiva rectoral, la gerencia de estas organizaciones cuenta con herramientas para superar su crisis institucional (anterior a la aparición del Covid-19), recomendándose fortalecer su comunicación con la comunidad interna y externa a ellas, para lograr que la transparencia y fluidez informativa de sus planes les permitan conseguir el apoyo y la unificación de voluntades necesarios para recuperar su prestigio.
Typical mistakes in the writing speech of bilingual students
Authors: Dinevich Irina Aleksandrovna
Published: September 2021

This article is devoted to considering of the phenomenon of bilingualism from the point of view of linguistic, psycholinguistic, psychological, and pedagogical aspects, the characteristics of typical mistakes that bilingual students make in writing when studying the lexical and grammatical norms of the modern Russian literary language. The article discusses scientific approaches to describing the problem of bilingualism by Russian and foreign authors (Avrorin, 1972; Shcherba, 1974; Vereshchagin, 2014; Weinreich, 1972; Agar, 1994; Breton, 1991; Lambert, 1963). The methodological basis of the research is made up of general scientific methods: the method of complex theoretical analysis of the problem under study, logical methods of analysis of scientific concepts, methodological analysis of 16 written works of bilingual students 1st year in the discipline "Business communications and speech culture". The result of the research is a description of typical lexical and grammatical errors in the written language of bilingual students, and the presentation of practical recommendations for increasing the effectiveness of students' mastering of the norms of the Russian literary language. It is concluded that deep involvement in the language content plan, modern knowledge of the lexical and grammatical norms of the modern Russian literary language will help bilingual students competently express their thoughts in oral and written speech form and be active participants in effective intercultural communication.
Open innovation from the university to local enterprises: conditions, complexities, and challenges
Authors: Álvarez-Castañón Lorena del Carmen , Palacios-Bustamante Rafael
Published: September 2021

The paper aimed to analyze the open innovation model from the Latin-American public university and the main factors that influence it. The interaction between the university with its ecosystem, its innovation and technology management, the profile of the academic community, and innovation policies were studied. The research methodology had a qualitative approach. And the process was integrated into three phases to identify the categories of open innovation, categorized the interaction between the university with the innovation ecosystem in four Mexican public universities, and triangulate the Latin-American behavior through semi-structured interviews to six academics. The main findings showed that open innovation is a feasible platform to link the Latin-American University with local enterprises despite the peculiar heterogeneous and unequal context of the ecosystem; furthermore, four collaborative flows between the university and the ecosystem were identified –inside, outside, mixed and hybrid-. In conclusion, the interdisciplinary approach, the techno-institutional networks, and the institutional policy influence open innovation from the university to the ecosystem, where the academic community is a mediator variable. Finally, it is highlighted that new re-institutionalization of innovation policies based on digital transformation and environmental sustainability are required; thus, Latin-American Schools of Innovation Taught are needed to encourage them.
Financiamiento para investigaciones en innovación social de la academia latinoamericana: retos y desafíos
Authors: Vargas Sáenz Mario Enrique , Escudero Cristina
Published: September 2021

Reflexionar sobre los retos y desafíos que un tema tan actual pero tan complejo como la innovación social encuentra en las decisiones y financiamientos de investigación en las Universidades Latinoamericanas se constituye en propósito a la vez que en una oportunidad para convocar la reflexión y el compromiso de las partes interesadas. Si bien las innovaciones pueden tener un impacto en la forma en que las personas se relacionan entre sí, autores como Putnam resaltan que se involucran en la sociedad y construyen capital social y el valor social refleja efectos positivos para los individuos, las comunidades y para sociedad. Este valor social a nivel micro, como en el beneficio que una persona obtiene al comprar una nueva tecnología, un medicamento o incluso un viaje a la tienda de comestibles, y a nivel individual, es lo que una persona valora más que el dinero pagado, como una computadora o una receta por lo que puede ser verdaderamente transformador. Metodológicamente, en la revisión documental y con las respuestas obtenidas frente a la encuesta aplicada sobre el financiamiento de la investigación en innovación social en algunas Universidades Colombianas, Mexicanas y Peruanas, se evidencia la dificultad que enfrentan los investigadores en esta materia y la deuda que en aporte al conocimiento en Innovación Social aún tiene la academia latinoamericana pues la innovación social sigue habitando solamente los ámbitos de la extensión universitaria más no en el de la investigación, impidiendo una mayor creación de valor social y un mayor impacto en la transformación de su entorno desde el conocimiento con propósito. Al concluir, se señalará frente al momento actual de pandemia que enfrenta nuestra sociedad latinoamericana, cuáles podrán ser los retos y desafíos más urgentes para que nuestras universidades sigan siendo forjadoras de humanidad y sociedad.
Effect of population dynamics on Livelihood Security in rural Sri Lanka
Authors: Abeywardana Thanuksha
Published: September 2021

Out of 20.82 million total population of Sri Lanka, 81.70% of the population lives in rural areas (Quandl, 2015). From 2005 to 2016 government expenditure for agriculture based actions shows the trend of decreasing while the development policy gradually changes the path from agricultural based economy to an industrial based economy over last few decades. However, poverty head count measures in 2006/2007 of Sri Lanka indicate that the percentage of people living in poverty in the rural sector is significant and the percentage of underweight children in rural areas is 38.3%, which is considerably higher than that of urban areas (29.9%). Thus, this status brought about the primary research question of how does the country achieve livelihood security. Thus, the objectives of this research are, to examine the factors affecting livelihood security and to understand the view of rural communities’ population dynamics on livelihood security. The research was carried out in mixed research design. The results show that access to livelihood resources also was not affected by gender, age, education and household income. However, in the analysis, both males and females were dissatisfied with the access to livelihood resources. Thus, in forming and implementation of development policies Sri Lanka needs to ensure community livelihood security.
Society's Diversity in Influencing Education (Kudus Tower Case Study in Influencing Islamic Education)
Authors: Nugroho Muhammad Arief , Az Zafi Ashif
Published: September 2021

The purpose of this article is to find out how Islamic education in the area around the Kudus Tower is influenced religious community, as well as to find out the influence in Islamic education. The process of compiling this study used a qualitative approach. The data collection was done by conducting a literature study. It is known that the influence of a religious community for Islamic education in the area around the Kudus tower includes making students more familiar with Islam, as well as the special attitude of Islamic education institutions in educating their students. The results obtained from this study are Islamic educational institutions around the Kudus tower are growing rapidly and these educational institutions form students who excel in academics and have noble character. The main factor in the formation of the noble character of students is caused by the kiai who become teachers in educational institutions, a religious community environment, upholding the teachings of Islam and also side by side with the tomb of Sunan Kudus which is its own value.
Nahdlatul Ulama dan Perannya dalam Menyebarkan Nilai-Nilai Pendidikan Aswaja An-Nahdliyah pada Masyarakat Plural
Authors: Kharismatunisa' Ilma , Darwis Mohammad
Published: September 2021

Artikel ini hendak menjelaskan tentang penanaman nilai-nilai pendidikan Aswaja untuk melihat tumbuh kembangnya kehidupan keberagamaan. Proses penanaman nilai-nilai pendidikan Islam Aswaja sejatinya tidak hanya terjadi di lingkungan pendidikan formal saja. Lebih dari itu, nilai-nilai pendididikan aswaja sudah menjadi tradisi kuat yang terus dipertahankan masyarakat Nahdlatul Ulama. Artikel ini ditulis dengan menggunakan pendekatan kualitatif dengan lokasi penelitian di Kecamatan Senduro Lumajang. Kesimpulan menunjukkan bahwa nilai-nilai pendidikan Aswaja An-nahdliyyah yang ditanamkan pada masyarakat plural di Kecamatan Senduro mencakup beberapa aspek yaitu tawasuth, tasamuh, i'tidal dan tawazun. Peran Nahdlatul Ulama dalam proses penanaman nilai-nilai tawasuth dilakukan dengan metode pemahaman dan metode pembiasaan. Sedangkan penanaman nilai-nilai tasamuh dilakukan melalui program-program kegiatan MWCNU Senduro dengan metode pemahaman. Untuk penanaman nilai-nilai i’tidal dilakukan dengan metode pemahaman dan metode pembiasaan dan nilai-nilai tawazun dikemas dengan metode pemahaman dan metode pembiasaan.
The Metode Pendidikan Keteladanan Relevansi antara Qasidah Burdah dengan Teori Belajar Sosial Albert Bandura
Authors: Putri Intan Budiana , Muhid Abdul
Published: September 2021

Dalam pendidikan Islam, keteladanan  merupakan metode yang paling banyak terlihat hasilnya dan terbukti bersifat influentif di dalam membentuk moral, spiritual maupun sosial seorang anak. Qashidah Burdah melalui sya’ir-sya’ir nya yang begitu indah, yang menceritakan kisah Rasulullah yang terpilih, ditulis oleh seorang penyair yang alim. Merujuk pada  teori social learning, perilaku dibentuk oleh hubungan interaksi klien dengan lingkungannya. Teknik modeling adalah salah satu teknik yang disusun oleh Albert Bandura. Tujuan dari penelitian ini adalah untuk menganalisis nilai-nilai pendidikan keteladanan dalam syair-syair qasidah burdah dan relevansinya terhadap teori belajar sosial Albert Bandura. Harapan dari penelitian ini adalah agar dapat dijadikan sebagai gagasan pendekatan dalam proses pembelajaran untuk mengembangkan kapasitas belajar dengan metode keteladanan. Bentuk penelitian ini adalah penelitian kualitatif yang menggunakan prosedur penelitian pustaka (Library Research). Di dalam penelitian ini ditemukan bahwa di dalam qasidah burdah terdapat kisah-kisah Rasulullah yang dapat kita jadikan sebagai salah satu metode pembelajaran, yaitu metode keteladanan.
On the creation of databases to assess the impact of chemicals on the organoleptic and general sanitary limiting signs of the harmfulness in the water of water bodies
Authors: Sinitsyna Okana O. , Pivneva Ol’ga S. , Turbinsky Viktor V. , Morozova Lyubov F. , Kozyreva O. N. , Ryashentseva T. M. , Kirillova E. A.
Published: September 2021

Introduction. Information on the MPC (TAC) value and the limiting hazard sign is important for the analysis of the hazard of chemicals in the water of water bodies for the health of the population, serves as the basis for the development of preventive measures to ensure safe conditions for water use by the population. For the purpose of specifying the possible adverse effects of the influence of chemicals on the hygienic conditions of water use of the population, information is needed on the entire spectrum of the effects of chemicals on water quality indicators. Materials and methods. The object of the study was indicators characterizing the effect of chemicals on the organoleptic properties of water and the general sanitary regime of water bodies, algorithms for analyzing primary data to determine threshold concentrations for the effect on odor, color, turbidity, foaming, pH, general sanitary regime of water bodies - biochemical oxygen consumption, concentration of nitrogenous connections. To organize the databases, the standard apparatus of the Excel subBD electronic tables was used. The mathematical apparatus of data analysis, grouping and selection of critical indicators of limiting signs is presented. Conclusion. It is concluded that the use of databases allows to study the relationship “concentration - effect”, increases the reliability and accuracy of substantiating the threshold concentration of pollutants in water by the influence of limiting signs of harmfulness.
Prática docente com a robótica educativa: ensino de elementos da geometria plana
Authors: Provin Sara , Tonezer da Silva Juliano , Ferraz Pereira Luiz Henrique
Published: September 2021

O artigo descreve uma experiência pedagógica que analisou o potencial de uma sequência de atividades com a robótica educativa no ensino na aprendizagem de elementos básicos da geometria plana com, 11 estudantes de 6º e 7º anos do Ensino Fundamental, de uma escola pública municipal. Com as interfaces da robótica educativa, foi possível interagir e engajar os aprendizes, estimulando-os a pensar e criar situações que favoreceram suas aprendizagens sob a luz da teoria Construcionista. Além de potencializar o desenvolvimento de habilidades e competências, os resultados apontaram a necessidade de novas abordagens no uso dos recursos tecnológicos, inovando o ensino dos objetos do conhecimento propostos pela Base Nacional Comum Curricular para a componente Matemática. Conclui-se que a robótica educativa propicia o envolvimento ativo dos estudantes, por proporcionar um ambiente lúdico e favorável à pesquisa, aliando a capacidade em resolver situações-problema, em desenvolver o raciocínio lógico, a criatividade e o trabalho em equipe.
Sistem Pakar dalam Menganalisis Penyakit Kelenjar Getah Bening Menggunakan Metode Certainty Factor
Authors: Fajri Sri Layli , Nurcahyo Gunadi Widi
Published: September 2021

In general, a person is difficult do dermine whether a lump or swelling of the lymph nodes in the body, is just a normal lump or whether it has become cancer. If the lumph does not go away whitin a few days, the patient is required to immediately consult a doctor to get detailed information about the disease and how to treat it. Lymph nodes scattered in the human body are round and are part of the lymphatic system that plays a role in fighting viruses that enter the body. The cause of these enlarged lymph nodes can be due to the type of food consumed, congenital disease in the patient’s body (comorbid), infection to lymph node cancer (lymphoma). For this reason, an Expert System is needed by applying the Certainty Factor method in order to assist the public in analyzing lymph node disease by answering several questions regarding the symptoms experienced. This system is implementad using the PHP programming language and MySQL database. The result of this study show that the Certainty Factor method can work well in the Expert System analysis process. From the result of system trials with several patient data, the disease accuracy rate in the patient named S is 63% and the disease accuracy rate in the patient named MR is 68%. Besides being useful for an expert, this Expert System can help patients to find out the type of disease they are suffering from, the accuracy of disease, the method of treatment and a guide for making decisions.
Teachers as First Responders
Authors: Gouwens Judith
Published: September 2021

While there is much in the press about refugee and migrant children’s movements around the world and their status in the countries where they ultimately (or even temporarily) settle, how these children experience schooling and education is critical in mitigating the effects of the trauma they experience in their home countries, in the process of leaving their home communities or countries, in traveling to their new communities and countries and getting settled in those new communities and countries. This paper presents the stories of three teachers who work with migrant children in the United States Midwest. Interviews with these teachers show that they actively work to mitigate the trauma the migrant children have experienced by creating classrooms that welcome the children and their families, help them to have a sense of belonging in their schools and communities, and help the children develop feelings of confidence and competence, critical to overcoming toxic stress.
Role of Using iPad Technology in Enhancing Students' Motivation toward Learning the English Language
Authors: Tarazi Ayat , Arafat Suzan
Published: September 2021

This study aimed to find out the role of the iPad in enhancing students' motivation towards learning the English Language. The findings of the study showed that there were improvements in the level of student's performance during English classes. It also showed that there were positive attitudes towards using iPad in learning English from the parents' perspectives. The results also showed that the total degree of teachers’ attitudes towards the use of iPad in motivating students towards learning the English language is dramatically increasing. Based on these results, the researchers recommended the Ministry of Education, and teachers of English to adopt the iPad as an educational tool in their teaching.
Self-Reported Adherence to the Use of Clinical Practice Guidelines of Hypertensive Disorders of Pregnancy in Jordanian Hospitals
Authors: Sarah M. Alja’freh  , Lubna Abu-Shaikha
Published: September 2021

Background: Hypertensive Disorders of Pregnancy (HDP) represents a life-threatening event for womenand their families. A number of national and international Clinical Practice Guidelines (CPGs) of HDPhave been published, however their use in clinical practice is still not well documented as it is complex.Suboptimal adherence to CPGs may lead to unfavorable maternal and perinatal outcomes. The purpose ofthis study is to assess the level of adherence of Healthcare Providers (HCPs) including obstetricians, nurses,and midwives to the HDP CPG based on Health System Strengthening (HSS II) recommendations in Jordan.Methods: A cross-sectional study design is used. 270 HCPs are recruited from different healthcare sectorsthat provide maternal health care services to women who are at risk of developing HDP. Data is collectedthrough self-reported questionnaire.Conclusion: HCPs showed a suboptimal adherence of to evidence-based recommendations of HDP’sguidelines; particularly in the antepartum and postpartum period. The results of this study can be used byguideline developers to raise acceptance and applicability of the guideline recommendations. Also, it mayhelp healthcare stakeholders and policy makers in designing tailored strategies to ensure successful andsustainable guideline adoption and its implementation in evidence-based maternity care.
Partnering Public and School Librarians for School Readiness Programming
Authors: Bloomer Bridget Alexis
Published: September 2021

Partnerships from public and school librarians for programming can prove to be beneficial for connecting with the community. When collaborating for school readiness programs, such as a school readiness fair, the expertise can bring about the best resources and services that both the public and school librarians have to offer, alongside the other community leaders in early childhood education. The paper discusses how to create a school readiness fair based on a collaboration between public and school librarians. Covering aspects of networking, programs such as Every Child Ready to Read, and school curriculum standards, it brings about the best parts of collaborating for a community event.

 

Keywords: School Readiness, school libraries, public libraries, programming, kindergarten readiness
Lagniappe: Open Educational Resources Initiatives among North Carolina’s Community Colleges
Authors: Thomas William Joseph
Published: September 2021

This article describes early cooperative efforts among North Carolina's Community Colleges to provide open educational resources for campus programs and encourage their adoption.
G7 Ülkelerinde Sağlığın Yakınsaması Hipotezinin Geçerliliği: Panel Birim Kök Testlerinden Kanıtlar
Authors: ATILGAN Dilek , ÖZBEK Sefa
Published: September 2021

Yakınsama hipotezi, Neoklasik (Solow) büyüme teorilerine dayanmaktadır. Dünyada özellikle de COVİD-19 salgını sonrası artan sağlık harcamaları ile yakınsama hipotezinin geçerliliği temel sağlık göstergeleri üzerinde de tartışılmaya başlanmıştır. Söz konusu tartışmaların uzun süre güncelliğini koruyacağı değerlendirilmektedir. Küreselleşme sürecinde ekonomik, sosyokültürel ve teknolojik faktörlerin sağlık harcamalarını artırdığı ve ülke ekonomilerinin bu doğrultuda sağlık harcamalarını şekillendirdiği bilinmektedir. Bu çalışmada G7 (ABD, Birleşik Krallık, Almanya, Fransa, İtalya, Japonya ve Kanada) ülkelerinde 1995-2018 dönemi kişi başı sağlık harcaması, bebek ölüm oranı ve doğuşta yaşam beklentisi değişkenleri kullanılarak, yakınsama hipotezinin geçerliliği araştırılmaktadır. Ekonometrik yöntem olarak Nazlıoğlu ve Karul (2017) tarafından geliştirilen, kesitler arası bağımlılığı ve yapısal kırılmaları dikkate alan Fourier yaklaşımına dayanan Panel LM birim kök testi ve yapısal kırılmaları dikkate almayan Reese &Westerlund (2016) tarafından geliştirilen PANICCA testi kullanılmıştır. Bulgular, analize dâhil edilen sağlık göstergelerinde yakınsama hipotezinin geçersiz olduğunu ortaya koymaktadır.
KÖK HÜCRE ÜRETİMİ, İZOLASYONU VE TEDAVİDE KULLANIMI
Authors: KAYA Muhammet Mükerrem , TUTUN Hidayet
Published: September 2021

Kök hücreler, çok hücreli canlıların bütün doku ve organlarını oluşturan temel hücrelerdir. Mitoz bölünme ile farklı hücre ve doku tiplerine farklılaşma ve çoğalma yeteneğine sahiplerdir. Kök hücrelerin hasarlı hücreleri değiştirme veya organları yenileme yetenekleri bazı hastalıkların tedavisinde alternatif bir tedavi seçeneği olmasını sağlamıştır. Kök hücre biyolojisinin anlaşılması ve hastalıkların tedavisinde klinik uygulamalar üzerine yoğun çalışmalar yapılmaktadır. Son yıllarda özellikle kişiye özel tedavi seçeneklerinin ön plana çıktığı çalışmalar göze çarpmaktadır. Kök hücre biyolojisinde önemli ilerlemelere rağmen, embriyonik kök hücrelerle etik tartışmalar, tümör oluşumu ve doku reddi gibi konular bunların kullanımını sınırlandırmaktadır. Kök hücre teknolojisinin gelişmesiyle yakın gelecekte farklı alanlarda kullanılabilen kök hücrelerle elde edilen doku bankalarının oluşturulması ve kişiye özel tedavi stratejisine katkı sağlaması beklenmektedir. Bu derleme, kök hücre tanımı, kökeni ve sınıflandırılması ile bu hücrelerin rejeneratif tıptaki uygulamaları üzerine odaklanır.
Coronal Microjets in Quiet-Sun Regions Observed with the Extreme Ultraviolet Imager on Board the Solar Orbiter
Authors: Hou Zhenyong , Tian Hui , Berghmans David , Chen Hechao , Teriaca Luca , Schühle Udo , Gao Yuhang , Chen Yajie , He Jiansen , Wang Linghua , Bai Xianyong
Published: September 2021

We report the smallest coronal jets ever observed in the quiet Sun with recent high-resolution observations from the High Resolution Telescopes (HRIEUV and HRILyα
) of the Extreme Ultraviolet Imager on board the Solar Orbiter (SO). In the HRIEUV (174 Å) images, these microjets usually appear as nearly collimated structures with brightenings at their footpoints. Their average lifetime, projected speed, width, and maximum length are 4.6 minutes, 62 km s−1, 1.0 Mm, and 7.7 Mm, respectively. Inverted-Y shaped structures and moving blobs can be identified in some events. A subset of these events also reveal signatures in the HRILyα
(H i Lyα at 1216 Å) images and the extreme ultraviolet images taken by the Atmospheric Imaging Assembly (AIA) on board the Solar Dynamics Observatory (SDO). Our differential emission-measure (EM) analysis suggests a multithermal nature and an average density of ∼1.4 × 109 cm−3 for these microjets. Their thermal and kinetic energies were estimated to be ∼3.9 × 1024 erg and ∼2.9 × 1023 erg, respectively, which are of the same order of the released energy predicted by the nanoflare theory. Most events appear to be located at the edges of network lanes and magnetic flux concentrations, suggesting that these coronal microjets are likely generated by magnetic reconnection between small-scale magnetic loops and the adjacent network field.
Hyperfractionated radiotherapy for re-irradiation of recurrent esophageal cancer
Authors: Takeda Kazuya , Matsushita Haruo , Umezawa Rei , Yamamoto Takaya , Ishikawa Yojiro , Takahashi Noriyoshi , Suzuki Yu , Jingu Keiichi
Published: September 2021

Purpose: Re-irradiation is a treatment option for recurrent esophageal cancer patients with a history of radiotherapy, but there is a risk of severe late adverse effects. This study focused on the efficacy and safety of re-irradiation using hyperfractionated radiotherapy. Materials and Methods: Twenty-six patients who underwent re-irradiation by the hyperfraction technique using twice-daily irradiation of 1.2 Gy per fraction for recurrent esophageal cancer were retrospectively included in this study. The overall survival period after the start of secondary radiotherapy and the occurrence of late adverse effects were investigated. Results: Of 26 patients, 21 (81%) received re-irradiation with definitive intention and 21 (81%) underwent concurrent chemotherapy. The median re-irradiation dose was 60 Gy in 50 fractions in 25 treatment days, and the median accumulated irradiation dose in equivalent dose in 2 Gy per fraction was 85.4 Gy with an α/β value of 3. The median interval between two courses of radiotherapy was 21.0 months. The median overall survival period was 15.8 months and the 1-year and 3-year overall survival rates were 64.3% and 28.3%, respectively. Higher dose of re-irradiation and concurrent chemotherapy significantly improved survival (p < 0.001 and p = 0.019, respectively). Severe late adverse effects with the Common Terminology Criteria for Adverse Events grade 3 or higher were observed in 5 (19.2%) patients, and 2 (7.7%) of them developed a grade 5 late adverse effect. Conclusion: High-dose re-irradiation using a hyperfractionated schedule with concurrent chemotherapy might be related to good prognosis, while the rate of late severe adverse effects is not high compared with the rates in past reports.
Effect of Family Empowerment on Self Care of Patients with Type-2 Diabetes Mellitus: A Systematic Review
Authors: Pramita Rianti , Nasution Siti Saidah , Marlindawani Jenny
Published: September 2021

Introduction: Diabetes Mellitus Type 2 (T2DM) is a chronic disease that will be suffered for life, so it is necessary to provide education to patients and families so that it is easy to understand the course of the disease, prevention and obstacles in the management of T2DM. Family empowerment can be started by optimizing family functions to help patients with T2DM to adapt and comply with self-care actions through four dimensions, empathic (emotional), encouragement (reward), facilitative (instrumental), and participatory (participation). This systematic review aims to identify and evaluate the effect of family empowerment interventions on self-care for T2DM patients.
Methods: The database used for article searches consisted of EBSCO, PubMed and ProQuest using relevant keywords based on the topic and title of the study. The selection of articles used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) diagram method, the overall results were 2,635 articles and 8 articles that fit the inclusion criteria and were analyzed descriptively narrative and had met the methodological quality study according to JBI guidelines (Joanna Briggs Critical Appraising Methodology).
Results: 8 articles with the Family Empowerment Process Model intervention program and the Diabetes Mellitus Education Program which is a family-oriented program that includes education classes, group discussions, home visits, and telephone follow-up. Education is provided to families through direct discussion and through telephone calls with a duration of each call of approximately 15 to 20 minutes scheduled for 9 am to 12 noon. Follow-up was done by telephone in the intervention group for approximately 3 months to 12 months.
Conclusion: The findings of this systematic review indicate that family empowerment interventions based on health education can have a good effect on improving self-care for patients with type 2 diabetes mellitus
A Literature Review on the Vaccination of COVID-19 in Pregnant and Breastfeeding Women: Effectiveness and Safety
Authors: Damayanti Fitriani Nur , Riafisari Alfina Aprilia , Ngestiningrum Ayesha Hendriana
Published: September 2021

Background: Pregnant women and breastfeeding women who are infected with the COVID-19 virus have a high risk, but pregnant women and women who breastfeed are not included in the initial vaccine trial for coronavirus 19 (COVID-19). There are currently no clinical data on the use of the COVID-19 mRNA vaccine in pregnant and lactating women. Aim: This study aims to get a picture about nurse’s knowledge, attitude and supervision, and its relationship to the implementation of pain reassessment. Methods: The method used in this paper is the Literature Review study. The data based used in the source search were Google Scholar, PubMed, JAMA, and AJOG which aimed to collect themes regarding the discussion of COVID-19 Vaccination in Pregnant and Breastfeeding Women. The COVID-19 mRNA vaccine creates immunity in pregnant and lactating women. Results: IgG immunoglobulin after vaccination in pregnant, lactating and non-pregnant women increased significantly and was stronger than pregnant women who were previously infected with SARS-CoV-2 Conclusion: Pregnant and lactating women have a stronger immune response after being vaccinated than pregnant women who were previously infected with SARS-CoV-2. Immune transfer to neonates occurs through placenta and breast milk, antibodies are formed after vaccination in the third trimester of pregnancy. Immunogenicity and reactogenicity reactions after the vaccine are the same as for nonpregnant women. Therefore, education is needed by health workers to patients about the risks and benefits of vaccines for pregnant and lactating women.