bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPROVING THE DEVELOPMENT OF SPORTS IN THE CONDITIONS OF UKRAINE: A SOCIOLOGICAL STUDY
Authors:   Dnipro State Academy of Physical Culture and Sports, Dnipro, Ukraine, Prykhodko Volodymyr , Sheviakov Oleksii ,   Ukrainian State University of Science and Technology, Dnipro, Ukraine,, Dolbysheva Nina ,   Dnipro State Academy of Physical Culture and Sports, Dnipro, Ukraine, Cherednichenko Oleksii ,   Khortytsk’ National Educational and Rehabilitation Academy, Zaporizhzhia, Ukraine
Published: December 2023

The purpose of the article was to record and track, based on a set of indicators, the opinion of experts regarding the practice of using the "sports region" effect to improve the development of the field of sports in the conditions of a separate region and Ukraine. Methods. The main method of collecting empirical material is an expert survey using a questionnaire. The methods of extrapolation, exploratory and normative forecasting were used to analyze the obtained statistical material. The results. Taking into account the existence of "sports regions" should be an important part of the strategy for the development of Olympic and non-Olympic sports in Ukraine, as this is confirmed by the support of experts. To achieve this, sports organizations and authorities should develop plans aimed at supporting the development of sports in individual regions. Scientific novelty. The study revealed the peculiarities of the development of the sphere of sports in the conditions of Ukraine. The practical significance. In view of supporting the development of sports that already have long-term and steady success, it is important to provide financial support, infrastructural base and promote the popularization of these sports in the areas where they are most developed. To achieve faster results in sportsmanship, the allocation of resources and support to athletes and teams from regions that already have a high level of achievement should be promoted. Institutions of higher education in the regions of Ukraine should include in the planning of scientific research the analysis of "sports regions" to improve the scientific base and development of sports. Keywords: sport, improvement, development, psychotherapy, sociological research, regions of Ukraine
ESTABLISHMENT OF FISCAL POLICY OF CHINA AND UKRAINE AND PROSPECTS FOR THE DEVELOPMENT OF UKRAINIAN-CHINESE ECONOMIC ACTIVITIES
Authors:   Lviv Polytechnic National University, Lviv, Ukraine, Zhang Shu , Yastrubskyy Mykhailo ,   Lviv Polytechnic National University, Lviv, Ukraine
Published: December 2023

The article examines the formation of the fiscal policy of the People's Republic of China and the fiscal policy of Ukraine. The theoretical aspects of the formation of fiscal policy are highlighted, the stages of the formation of the fiscal policy of China and Ukraine in historical retrospect are given. The description of reforming the fiscal and tax system of China is carried out with reference to the achieved successes in the socio-economic development of the country. An overview of the trade and economic relations between Ukraine and China is provided. Based on the current state of the socio-economic situation of both countries, the prospects for the development of Ukrainian-Chinese economic activity are described and the need to harmonize the fiscal policies of the countries is substantiated. Keywords: Fiscal policy, Ukrainian-Chinese economic relations, fiscal policy reform, tax system.
ChatGPT for education and research: A review of benefits and risks
Authors: Sok Sarin , Heng Kimkong
Published: December 2023

Generative Pre-trained Transformer (ChatGPT) is an artificial intelligence (AI) tool that can quickly generate detailed responses to prompts and follow-up questions. This emerging AI tool was launched in November 2022 by an American AI research laboratory, called OpenAI, using large language models. In this article, the benefits and risks related to the use of ChatGPT in education and research are discussed. The article argues that ChatGPT has at least five main benefits, such as creating learning assessment, enhancing pedagogical practice, offering virtual personal tutoring, creating an essay or research article outline, and brainstorming ideas. However, there are risks related to academic integrity issues, unfair learning assessment, inaccurate information, and over-reliance on AI. The article offers a set of recommendations for effective use of ChatGPT for educational and research purposes.
Honorer la trajectoire et le vécu de mères innues
Authors: Croteau Karine
Published: December 2023

À partir d’une perspective constructiviste et de données empiriques recueillies auprès de neuf mères innues, dont au moins un enfant a fait l’objet d’une mesure de protection, l’auteure met en dialogue le contexte sociohistorique des services de protection, l’empreinte du colonialismebio-psycho-spirit-social1au Québec et les trajectoires de mères innues.Plus précisément, l’attention est portée sur les expériences singulières vécues par ces mères au contact des services de protection de la jeunesse, à leurs rapports aux travailleuses sociales et à l’institution ainsi qu’à trois pistes prometteuses permettant d’accroître la sécurisation culturelle dans les services. L’ancrage épistémologique privilégié valorise les expériences, apprentissages et savoirs desparticipantes-expertes.Des extraits de récits biographiques sont présentés. Placés à l’avant-scène du propos, ces extraits visent avant tout à honorer la parole des principales concernées et à respecter leurs conceptions du monde, leurs vécus et leurs valeurs.
Revelació, apoteosi i confirmació. El retaule de la Transfiguració de la Catedral de Tortosa
Authors: Gregori Rubén
Published: December 2023

Resum: En aquest article es pretén posar de relleu la paradigmàtica iconografia del retaule de la Transfiguració de la Catedral de Tortosa atribuït a Rafael Vergós i Pere Alemany (ca. 1498). Primerament s’analitzarà el significat i l’empremta de l’episodi del Nou Testament i es posarà en relació amb les escenes escollides per al conjunt retablístic. D’igual manera, es destacarà el possible rol del context socioreligiós del moment com a eix articulador del programa visual de l’obra.Paraules clau: Transfiguració, Moisès, Elies, revelació, conciliacióAbstract: This article aims to highlight the paradigmatic iconography of the altarpiece of the Transfiguration of the Cathedral of Tortosa attributed to Rafael Vergós and Pere Alemany (ca. 1498). Firstly, the meaning and imprint of the episode of the New Testament will be analyzed and it will be put in relation to the scenes chosen for the altarpiece. In the same way, it will be highlighted the possible role of the socio-religious context of the moment as an articulating axis of the visual program of the artwork.Keywords: Transfiguration, Moses, Elijah, revelation, conciliation
Nèstor Luján e Joan Perucho, ‘gastrófogos’ al servizio della serenissima: racconti di cibi e spezie sulle rotte del Mediterraneo d’Oriente
Authors: Carol Geronès Lídia
Published: December 2023

Riassunto: Attraverso un approccio trasversale, in questo articolo si analizzano alcuni dei primi testi sulla gastronomia di Nèstor Luján e Joan Perucho, apparsi nella rivista Destino, in cui, seppur con differenti intenti, i due autori scrivono di cibo e interscambio di alimenti nella cucina mediterranea, con una attenzione speciale ad un possibile dialogo con il territorio italiano, osservando principalmente il caso Venezia, considerata porta d’Oriente e unicum urbano sulle rotte del Mediterraneo levantino e bizantino.Parole chiave: Nèstor Luján, Joan Perucho, letteratura e cibo, identità e gastronomia, VeneziaAbstract: Using a transversal approach, this article analyses some of the first texts on gastronomy by Nèstor Luján and Joan Perucho, which appeared in the magazine Destino, in which, although with different intentions, the two authors write about food and the exchange of foods in Mediterranean cuisine, with special attention to a possible dialogue with the Italian territory, mainly observing the case of Venice, considered the gateway to the East and an urban unicum on the Levantine and Byzantine Mediterranean routes.Keywords: Nèstor Luján, Joan Perucho, literature and food, identity and gastronomy, Venice
«Amb dits de rosa l’aurora»: versions catalanes d’Homer
Authors: Turull Crexells Isabel
Published: December 2023

Resum: El tema del XIII Congrés Internacional de l’AISC, «Històries d’un mar en comú. Alimentació, vida i mort a les rutes de la Mediterrània oriental», ens proporciona una ocasió per a passar revista a les traduccions de la Ilíada i l’Odissea. En el nostre paper ens fixem en les diverses traduccions al català d’aquests poemes que són la base de la nostra cultura europea i que mostren per una banda la vida i la mort davant l’alta ciutat de Troia i per l’altra el viatge d’Ulisses de retorn a la seva illa d’Ítaca. Les traduccions analitzades són les que considerem clàssiques, començant per les dues grans Odissees ribianes, però també les més modernes, com les dues Ilíades de 2019, una en prosa de Montserrat Ros per a Adesiara i una en vers per a la Bernat Metge Universal de Pau Sabaté. Per a la nostra anàlisi tenim en compte les decisions dels traductors respecte als colors, respecte a la mar amb tots els seus qualificatius i respecte als símils, especialment els símils llargs i per tant més complexos.Parole chiave: Traducció, Homer, epítets homèrics, símils   .Abstract: The theme of the XIII International Congress of the AISC, «Stories of a common sea. Food, life and death on the routes of the eastern Mediterranean», provides us with an opportunity to review the translations of the Iliad and the Odyssey. In our paper we examine the various translations into Catalan of these poems which are the basis of our European culture and which show on the one hand life and death before the high city of Troy, and on the other the journey of Odysseus’ return to his island of Ithaca. The translations analyzed are the ones we consider classics, starting with the two great Ribian Odysseys, but also the most modern ones, such as the two Iliads of 2019, one in prose by Montserrat Ros for Adesiara and one in verse for Bernat Metge Universal by Pau Sabaté. We take into account the translators’ decisions regarding colors, regarding the sea with all its qualifiers and regarding similes, especially the longest and more complex ones.Keywords: Translation, Homer, Homeric epithets, similes
Acostaments al Curial e Güelfa: literatura, llengua i traducció.
Authors: Garcia Sebastià Josep Vicent , Martines Peres Vicent
Published: December 2023

Presentació monogràfic
The Na+ leak channel NALCN controls spontaneous activity and mediates synaptic modulation by α2-adrenergic receptors in auditory neurons
Authors: Ngodup Tenzin , Irie Tomohiko , Elkins Sean , Trussell Laurence O.
Published: December 2023

Cartwheel interneurons of the dorsal cochlear nucleus (DCN) potently suppress multisensory signals that converge with primary auditory afferent input, and thus regulate auditory processing. Noradrenergic fibers from locus coeruleus project to the DCN, and α2-adrenergic receptors inhibit spontaneous spike activity but simultaneously enhance synaptic strength in cartwheel cells, a dual effect leading to enhanced signal- to-noise for inhibition. However, the ionic mechanism of this striking modulation is unknown. We generated a glycinergic neuron-specific knockout of the Na
+
leak channel NALCN, and found that its presence was required for spontaneous firing in cartwheel cells. Activation of α2-adrenergic receptors inhibited both NALCN and spike generation, and this modulation was absent in the NALCN knockout. Moreover, α2-dependent enhancement of synaptic strength was also absent in the knockout. GABA
B
receptors mediated inhibition through NALCN as well, acting on the same population of channels as α2 receptors, suggesting close apposition of both receptor subtypes with NALCN. Thus, multiple neuromodulatory systems determine the impact of synaptic inhibition by suppressing the excitatory leak channel, NALCN.
Homeodomain proteins hierarchically specify neuronal diversity and synaptic connectivity
Authors: Xu Chundi , Ramos Tyler B. , Rogers Edward M. , Reiser Michael B. , Doe Chris Q.
Published: December 2023

How our brain generates diverse neuron types that assemble into precise neural circuits remains unclear. Using
Drosophila
lamina neuron types (L1-L5), we show that the primary homeodomain transcription factor (HDTF) Brain-specific homeobox (Bsh) is initiated in progenitors and maintained in L4/L5 neurons to adulthood. Bsh activates secondary HDTFs Ap (L4) and Pdm3 (L5) and specifies L4/L5 neuronal fates while repressing the HDTF Zfh1 to prevent ectopic L1/L3 fates (control: L1-L5; Bsh-knockdown: L1-L3), thereby generating lamina neuronal diversity for normal visual sensitivity. Subsequently, in L4 neurons, Bsh and Ap function in a feed-forward loop to activate the synapse recognition molecule DIP-β, thereby bridging neuronal fate decision to synaptic connectivity. Expression of a Bsh:Dam, specifically in L4, reveals Bsh binding to the
DIP-β
locus and additional candidate L4 functional identity genes. We propose that HDTFs function hierarchically to coordinate neuronal molecular identity, circuit formation, and function. Hierarchical HDTFs may represent a conserved mechanism for linking neuronal diversity to circuit assembly and function.
The reuniens nucleus of the thalamus facilitates hippocampo-cortical dialogue during sleep
Authors: Basha Diellor , Azarmehri Amirmohammad , Proulx Eliane , Chauvette Sylvain , Ghorbani Maryam , Timofeev Igor
Published: December 2023

Memory consolidation during sleep depends on the interregional coupling of slow waves, spindles, and sharp wave-ripples (SWRs), across the cortex, thalamus, and hippocampus. The reuniens nucleus of the thalamus, linking the medial prefrontal cortex (mPFC) and the hippocampus, may facilitate interregional coupling during sleep. To test this, electrophysiological recordings were obtained in vivo from the cat reuniens nucleus, prefrontal cortex and hippocampus. Interregional synchrony was measured using phase-amplitude coupling and interregional time delays between SWRs, spindles and slow waves together with reuniens spiking and local field potential (LFP) activity. Electrical stimulation of the reuniens evoked intracellular mPFC responses, consistent with bidirectional functional connectivity between mPFC-reuniens and hippocampus. Cortical slow waves preceded reuniens slow waves and hippocampal SWRs. Hippocampal SWRs and REM sleep theta modulated reuniens activities and reuniens spindles preceded cortical spindles. The neural mass model of this network demonstrates that the strength of bidirectional hippocampo-thalamic connections determines the coupling of oscillations, suggesting a mechanistic link between synaptic weights and the propensity for interregional synchrony.The nucleus reuniens of the thalamus play a central role in synchronizing the mPFC-hippocampal network during sleep and integrates converging activity from hippocampal and mPFC oscillations.
Respiratory and Cardiac Interoceptive Sensitivity in the First Two Years of Life
Authors: Tünte Markus R , Hoehl Stefanie , Wunderwald Moritz , Bullinger Johannes , Boyadziheva Asena , Maister Lara , Elsner Birgit , Tsakiris Manos , Kayhan Ezgi
Published: December 2023

Several recent theoretical accounts have posited that interoception, the perception of internal bodily signals, plays a vital role in early human development. Yet, empirical evidence of cardiac interoceptive sensitivity in infants to date has been mixed. Furthermore, existing evidence does not go beyond the perception of cardiac signals and focuses only on the age of 5–7 months, limiting the generalizability of the results. Here, we used a modified version of the cardiac interoceptive sensitivity paradigm introduced by Maister et al. (2017) in 3-, 9-, and 18-month-old infants using cross-sectional and longitudinal approaches. Going beyond, we introduce a novel experimental paradigm, namely the iBREATH, to investigate respiratory interoceptive sensitivity in infants. Overall, for cardiac interoceptive sensitivity (
total n
= 135) we find rather stable evidence across ages with infants on average preferring stimuli presented synchronously to their heartbeat. For respiratory interoceptive sensitivity (
total n
= 120) our results show a similar pattern in the first year of life, but not at 18 months. We did not observe a strong relationship between cardiac and respiratory interoceptive sensitivity at 3 and 9 months but found some evidence for a relationship at 18 months. We validated our results using specification curve- and mega analytic approaches. By examining early cardiac and respiratory interoceptive processing, we provide evidence that infants are sensitive to their interoceptive signals.
Respiratory and Cardiac Interoceptive Sensitivity in the First Two Years of Life
Authors: Tünte Markus R. , Höhl Stefanie , Wunderwald Moritz , Bullinger Johannes , Boyadziheva Asena , Maister Lara , Elsner Birgit , Tsakiris Manos , Kayhan Ezgi
Published: December 2023

Several recent theoretical accounts have posited that interoception, the perception of internal bodily signals, plays a vital role in early human development. Yet, empirical evidence of cardiac interoceptive sensitivity in infants to date has been mixed. Furthermore, existing evidence does not go beyond the perception of cardiac signals and focuses only on the age of 5-7 months, limiting the generalizability of the results. Here, we replicated the cardiac interoceptive sensitivity paradigm introduced by Maister et al. (2017) in 3-, 9-, and 18-month-old infants using cross-sectional and longitudinal approaches. Going beyond, we introduce a novel experimental paradigm, namely the iBREATH, to investigate respiratory interoceptive sensitivity in infants. Overall, for cardiac interoceptive sensitivity (total n = 146) we find rather stable evidence across ages with infants on average preferring stimuli presented synchronously to their heartbeat. For respiratory interoceptive sensitivity (total n = 126) our results show a similar pattern in the first year of life, but not at 18 months. We did not observe a strong relationship between cardiac and respiratory interoceptive sensitivity at 3 and 9 months but found some evidence for a relationship at 18 months. We validated our results using specification curve- and mega analytic approaches. By examining early cardiac and respiratory interoceptive processing, we provide compelling evidence that infants are sensitive to their interoceptive signals.
A genome-wide nucleosome-resolution map of promoter-centered interactions in human cells corroborates the enhancer-promoter looping model
Authors: Golov Arkadiy K. , Gavrilov Alexey A. , Kaplan Noam , Razin Sergey V.
Published: December 2023

The enhancer-promoter looping model, in which enhancers activate their target genes via physical contact, has long dominated the field of gene regulation. However, the ubiquity of this model has been questioned due to evidence of alternative mechanisms and the lack of its systematic validation, primarily owing to the absence of suitable experimental techniques. In this study, we present a new MNase-based proximity ligation method called MChIP-C, allowing for the measurement of protein-mediated chromatin interactions at single-nucleosome resolution on a genome-wide scale. By applying MChIP-C to study H3K4me3 promoter-centered interactions in K562 cells, we found that it had greatly improved resolution and sensitivity compared to restriction endonuclease-based C-methods. This allowed us to identify EP300 histone acetyltransferase and the SWI/SNF remodeling complex as potential candidates for establishing and/or maintaining enhancer-promoter interactions. Finally, leveraging data from published CRISPRi screens, we found that most functionally-verified enhancers do physically interact with their cognate promoters, supporting the enhancer-promoter looping model.
The influence of diet on gut microbiome and body mass dynamics in a capital-breeding migratory bird
Authors: Jones Isabelle , Marsh Kirsty , Handby Tess M. , Hopkins Kevin , Slezacek Julia , Bearhop Stuart , Harrison Xavier A.
Published: December 2023

Gut-associated microbial communities are known to play a vital role in the health and fitness of their hosts. Though studies investigating the factors associated with among-individual variation in microbiome structure in wild animal species are increasing, knowledge of this variation at the individual level is scarce, despite the clear link between microbiome and nutritional status uncovered in humans and model organisms. Here, we combine detailed observational data on life history and foraging preference with 16S rRNA profiling of the faecal microbiome to investigate the relationship between diet, microbiome stability and rates of body mass gain in a migratory capital-breeding bird, the light-bellied Brent goose (Branta bernicla hrota). Our findings suggest that generalist feeders have microbiomes that are intermediate in diversity and composition between two foraging specialisms, and also show higher within-individual plasticity. We also suggest a link between foraging phenotype and the rates of mass gain during the spring staging of a capital breeder. This study offers rare insight into individual-level temporal dynamics of the gut microbiome of a wild host. Further work is needed to uncover the functional link between individual dietary choices, gut microbiome structure and stability, and the implications this has for the reproductive success of this capital breeder.
Cyclin-dependent kinase inhibitor 1 plays a more prominent role than activating transcription factor 4 or the p53 tumour suppressor in thapsigargin-induced G1 arrest
Authors: van Zyl Erin , Peneycad Claire , Perehiniak Evan , McKay Bruce C.
Published: December 2023

Background

Thapsigargin (Tg) is a compound that inhibits the SERCA calcium transporter leading to decreased endoplasmic reticulum (ER) Ca2+ levels. Many ER chaperones are required for proper folding of membrane-associated and secreted proteins, and they are Ca2+ dependent. Therefore, Tg leads to the accumulation of misfolded proteins in the ER, activating the unfolded protein response (UPR) to help restore homeostasis. Tg reportedly induces cell cycle arrest and apoptosis in many cell types but how these changes are linked to the UPR remains unclear. The activating transcription factor 4 (ATF4) plays a key role in regulating ER stress-induced gene expression so we sought to determine if ATF4 is required for Tg-induced cell cycle arrest and apoptosis using ATF4-deficient cells.

Methods

Two-parameter flow cytometric analysis of DNA replication and DNA content was used to assess the effects of Tg on cell cycle distribution in isogenic HCT116-derived cell lines either expressing or lacking ATF4. For comparison, we similarly assessed the Tg response in isogenic cell lines deleted of the p53 tumour suppressor and the p53-regulated p21WAF1 cyclin-dependent kinase inhibitor important in G1 and G2 arrests induced by DNA damage.

Results

Tg led to a large depletion of the S phase population with a prominent increase in the proportion of HCT116 cells in the G1 phase of the cell cycle. Importantly, this effect was largely independent of ATF4. We found that loss of p21WAF1 but not p53 permitted Tg treated cells to enter S phase and synthesize DNA. Therefore, p21WAF1plays an important role in these Tg-induced cell cycle alterations while ATF4 and p53 do not. Remarkably, the ATF4-, p53-and p21WAF1-deficient cell lines were all more sensitive to Tg-induced apoptosis. Taken together, p21WAF1 plays a larger role in regulating Tg-induced G1 and G2 arrests than ATF4 or p53 but these proteins similarly contribute to protection from Tg-induced apoptosis. This work highlights the complex network of stress responses that are activated in response to ER stress.
EFFICACY OF UNANI FORMULATION MARHAM KAFOOR IN THE MANAGEMENT OF IRRITANT CONTACT DERMATITIS (NAR FARSI): A CASE REPORT
Authors: Tehseen Ayesha , Wani Khalid Rahim , Ali Hamid
Published: December 2023

Background: Irritant contact dermatitis (ICD) is the most typical kind of occupational skin disease and is an inflammatory cutaneous disorder. Objective: This case report aims to provide insight into the effects of Marham Kafoor in ICD. Intervention: A 50-year-old male presented with lesions on his left foot, accompanied by serous discharge, severe itching, and a burning sensation. For a period of 45 days, Marham Kafoor was topically applied twice a day at a dose of 6-8 gm. The patient was assessed on the 0th day, 15th day, 30th day, and 45th day on the basis of the EASI, POEM, and VAS. Results: After the intervention, significant improvement was observed in all scales from baseline to 45th day. EASI changes from 21 (moderate) to 4 (mild), POEM changes from 23 (severe) to 5(mild), and VAS from 9 (severe) to 3 (mild). Skin lesions began to improve on the 15th day and almost resolved after the 45th day. Conclusion: Marham Kafoor has been proven beneficial in treating ICD and enhancing patients' quality of life. To determine the effectiveness of Marham Kafoor in the management of eczema, rigorous, controlled, randomized, blinded, and long-term follow-up studies on high sample sizes are required.
Effects of an Inclined Cente red Conductor on MHD Natural and Forced Convection Within a Heated Wavy Chamber
Authors: Juma S. O. , Sigey J. K. , Abonyo J. O. , Maritim S. K.
Published: December 2023

The study of the effect of hall and ion slip on an inclined conductor on MHD natural and forced convection in a heated wavy chamber with a constant transversal magnetic field applied. The governing momentum and energy equation were solved by applying finite central scheme approximation and the resulting partial difference equations were solved by MATLAB software.  The study showed that an increase heat absorption coefficient lowers the surface heat transfer thus lowering flow rate. An increase in Rayleigh number increases the flow rate while an increase in the angle of inclination of the conductor increases the buoyancy force component thereby increasing the flow rate. The results further showed that flow rate became higher at an inclination angle of 90º. In addition, the results also showed that an increase in Hartmann increases the flow rate. The Hartmann number, Rayleigh number and Absorption coefficient are analytically discussed and represented in tables and graphical profiles with respect to flow velocity and temperature profile due to engineering demand. This current study a direct application in the development of MHD propelled vessels in the marine and space-craft department.
Secondary Erythrocytosis, a Predominant Cause of Polycythemia- Clinical and Laboratory Evaluation of Polycythemia in a Tertiary Care Center
Authors: Aamir Zunaira , Mushtaq Mamona , Sheikh Sumera
Published: December 2023

Aims: Polycythemia refers to an increased production of red blood cells from bone marrow. It is one of the frequent reasons for a hematology consultation. The present work aimed to examine the causes, clinical manifestations, prevalence, and diverse patterns in laboratory and clinical parameters among patients with polycythemia attending our outpatient clinics at the Indus Hospital and Health Network.

Study Design: The present work is retrospective observational study which included all cases of polycythemia.

Place and Duration of the Study: The study was conducted at a tertiary health care center in Karachi, Pakistan during October 2019 to July 2021.

Methodology: The data from the patient diagnosed with polycythemia was entered and analyzed by using SPSS version 24.0. Descriptive statistics as per the Gaussian Normality distribution (Sapiro-Wilk) were computed along with frequencies. The association where applicable was calculated via standard statistical methods with the chi square test for categorical while independent sample t-test for the continuous variables. The level of statistical significance will be set at P < 0.05.

Results: During the investigated period, a total of 33 patients were diagnosed with polycythemia demonstrating a notable male predominance (82%). The majority of the patients exhibited secondary erythrocytosis (85%) with only a minority (15%) diagnosed with polycythemia vera. Of the identified cases of secondary erythrocytosis a significant proportion (46%) was observed in individuals who were smokers while other were found with hypoxic pulmonary disease, hepatitis, and chronic kidney disease. In secondary erythrocytosis 21 patients (75%) required venesection for symptom reduction, while 7 (25%) were closely monitored due to their asymptomatic status. On the contrary all cases of polycythemia vera required a comprehensive treatment approach including venesections, cytoreduction with hydroxyurea and low dose aspirin.
Comparative Field Efficacy of Certain Insecticides against Paddy Leaf Folder Infestation
Authors: Reddy L. P. V. , Rao S. R. K. , Krishna T. M. , Rao C. H. S.
Published: December 2023

A field experiment which was conducted during rabi, 2016-17 and 2017-18 in the wetland farm of S.V. Agricultural College, Tirupati to evaluate the efficacy of certain insecticides against rice leaf folder in paddy variety, BPT-5204 revealed that, all the tested ten insecticides had significantly affected the larvae of C. medinalis and reduced the leaf damage over untreated control. The chlorantraniliprole proved as the most effective insecticide with the percentage of leaf damage as 4.95 followed by flubendiamide and monocrotophos with the damage percentage of 5.44 and 5.53. The least effective insecticides were cartap hydrochloride 4 G (7.39%)   followed by cartap hydrochloride 50 SP (7.33%) and acephate (7.19%) against paddy leaf folder damage.
Effect of Integrated Use of Poultry Manure with Fertilizer Urea for Sustainable Nitrogen Management in Rice (cv. BRRI Dhan 29) under Two Water Management Systems
Authors: Chadny Dulary Najnin , Onik Jakaria Chowdhury , Sarkar Drishti , Ahmed Foysal
Published: December 2023

The experiment was conducted at the Agronomy Field Laboratory, Bangladesh Agricultural University, Mymensingh. The experiment's objectives were to evaluate the performance of integrated management of poultry manure with chemical fertilizer urea and to seek water-saving technology that will allow rice (BRRI dhan 29) production to be maintained or increased in the face of declining water availability. The experiment comprised seven treatments viz. T1:100% N from poultry manure, T2:100% N recommended doses of prilled urea, T3:90% N from PU + 10% N from PM, T4:80% N from PU + 20% N from PM, T5: 70% N from PU + 30% N from PM, T6: 60% N from PU + 40% N from PM, T7: 50% N from PU + 50% N from PM. It was laid out in a split-plot design with three replications. The main plots were allocated for irrigation treatments (alternate wetting and dying and continuous flooding) and sub-plots for nitrogen treatments. Altogether, 42 unit plots were conducted, each measuring 2.5mx2.5m. The application of different nitrogen levels significantly influenced all the growth parameters. Irrigation levels significantly affected all the yield and yield contributing characters except plant height, number of ineffective tillers, panicle length, unfilled grain per panicle, 1000 grain weight and harvest index. The highest value of total tiller/hill (11.01), number of effective tillers per hill (9.72), filled grain per panicle (132.23), grain yield (4.80), straw yield (6.68), biological yield (11.47) was observed in the two-irrigation system while height value of non-effective tiller/hill (1.29). The effect of nitrogen treatment was found to be significant. On the other hand, the interaction effect of irrigation management and treatments significantly influenced all the yield parameters except plant height, No. of tiller/ hill, no. of non-effective tiller/hill, panicle length, unfilled grain/panicle and 1000 grain weight. The height value of all those parameters was recorded at the I1×T2 (continuous flooding ×100% N recommended doses of prilled urea). The lowest value of all these parameters was recorded at the I2×T1 (AWDI × 100% N from poultry manure) and I1×T1 (continuous flooding × 100% N from poultry manure). The integrated use of 90% N from PU + 10% N from PM appeared as the better practice because of reducing the considerable amount of prilled urea in Boro rice (cv. BRRI dhan 29) cultivation in terms of grain yield. Moreover, the best promising practice was obtained using 100% N recommended doses of prilled urea applied with continuous flooding (CF).
Management of Sesame Phyllody: A Destructive Disease of East- Central Rajasthan, India
Authors: Yadav Pinki Devi , Yadav Pinki Devi , Rathore G. S. , Choudhary Sunita , Sharma R. S. , Meena Ranjana
Published: December 2023

Sesame (Sesamum indicum L.) is one of the important annual oldest oil seed crop grown in tropical to temperate zones in India. It belongs to family Pedaliaceae is native of India and plays an important role in the oilseed economy throughout the world. The sesame crop suffers from phyllody disease caused by phytoplasma. The effect of different treatments on “percent” disease incidence. The results obtained revealed that all the treatments reduced the disease significantly compared to unsprayed control. Seed treatment with imidachlorprid 70 % WG + spraying of imidachlorprid 17.8% SL+ spraying of tetracycline hydrochloride recorded the least disease incidence (7.27 %), minimum leaf hopper population and maximum “percent” disease control (65.59 %) and while seed treatment with imidachlorprid 70 % WG was least effective in which disease incidence of 15.46  “percent” and maximum leaf hopper population was recorded. The disease incidence in untreated check was 21.13 “percent” was recorded. Out of 22 germplasms/varieties screened against sesame phyllody 1 genotype was susceptible, 10 were moderately susceptible, 7 were moderately resistant and 4 genotypes were found resistant against phyllody of sesame.
Erysipelothrix rhusiopathiae: An Emerging Organism Causing Pleural Effusion in an Immunocompetent Child
Authors: Kapat Aritra , Roy Mrinmoy , Konar Jayashree , Mandal Asok Kumar , Bala Ashok Kumar
Published: December 2023

Aims: Erysipelothrix rhusiopathiae is a Gram-positive bacillus attributed to zoonotic infections primarily. In humans they usually cause localized cutaneous infections namely erysipeloid, occasionally becomes diffuse and may lead to septicemia and endocarditis in opportunistic immunocompromised individuals. The growing and evolving disease spectrum of this organism in human beings is a potential future threat. This case report addresses a common disease manifestation with this unusual organism which is needs to be highlighted.

Presentation of Case: Herein we report a case of 1year 9month old immunocompetent male child belonging to a shepherd family who presented with long standing left sided pleural effusion. Pleural fluid culture yielded Erysipelothrix rhusiopathiae. Despite a culture sensitive antibiotic therapy a sequelae of residual effusion with subpleural collapse and fibrous septations developed, hence left lateral thoracotomy along with decortication surgery was performed.

Discussion: This case report highlights the drug sensitivity and resistance pattern in detail and also points out the prognosis and possible sequelae of the disease which in turn can increase treatment awareness regarding the organism.

Conclusion: Erysipelothrix rhusiopathiae is an unusual organism which was found in our patient causing pleural effusion is a very unlikely coalition and needs a separate mention as this emerging microbe can be a cause of concern due to its novelty and scarce medical evidence.
The Impact of Social Media on Academic Performance, Health and Social Interaction of Students in University of Technology and Applied Sciences, Nizwa, Sultanate of Oman
Authors: Renjith Kumar R.  , Al-Rahbi Zainab Mohammad Nasser , Al-Daraai Najoud Salim Abdallah
Published: December 2023

The research aimed to contribute to investigate the impact of social networking media on academic performance, health and social interactions in Oman. It is a causal study as it studied the impact of social media usage on academics, social interactions and health. The study area was University of Technology and Applied sciences, Nizwa. The period of study was from February 2023 to May 2023. The total population of students studying in University of Technology and Applied Sciences, Nizwa is 5692 A sample of 242 students were selected for the study from four departments. Samples were designed from students in each department by using proportionate stratified sampling. Primary data was collected online using Google form, with the help of a structured questionnaire in English and Arabic. The findings of the study revealed that the correlation between social media usage and health issues is 0.174. There is a significant relationship between social media usage and its impact on health. Social media usage contributes only 3% to health issues on the students. The correlation between social media usage and social interactions and behaviour is 0.264. 7% of the variation in social behaviour can be predicted due to usage of social media. It is proved that there is a significant relationship between social media usage and its impact on social interactions and behavior of students. The correlation between social media usage and academic performance is 0.271. Social media usage contributes only 7% to academic performance of the students. It is proved that there is a significant relationship between social media usage and its impact on academic performance of students, their health and behaviour. There is no significant relationship between gender, department, level of study and grade with the usage of social media.
A Study of Language and Identity as Neocolonial Means in Firoozeh Dumas’ Funny in Farsi
Authors: Rezaeinejad Hamed , Sasani Samira
Published: December 2023

The phenomenon of migration, whether by choice or necessity, has shaped various spheres, giving rise to a corpus referred to as migrant literature. Many authors of this genre explore the sociopolitical contrasts between their current and native lands, sharing their experiences while sometimes allegedly concealing some aspects of the immigration process. This has sparked contentious debates that extend beyond the literary realm. Firoozeh Dumas’ well-known memoir, Funny in Farsi, humorously portrays the Iranian-American family’s journey through cultural disparities. In an attempt to reappraise this light-hearted approach to Dumas’ work, this research utilizes Ngugi wa Thiong’o’s language studies and Milton Gordon’s analysis of identity in diaspora. This study concludes that the Englishness of Dumas’ memoir and its narrative’s normalization of assimilation in the host country, align with the neo-colonial politics of the West theorized by Kwame Nkrumah. These neo-colonial dynamics of power in turn can potentially disrupt the ongoing decolonization process.
Red Badge of Courage and Jalan Tak Ada Ujung: Comparing Indonesia’s and America’s National Masculinity
Authors: Hidayatullah Danial
Published: December 2023

Masculinity linked to conflict or war is often seen as hegemonic. This research offers two literary texts from two different countries:  Stephen Crane’s The Red Badge of Courage (2005) and Muchtar Lubis’ Jalan Tak Ada Ujung (The Endless Road) (1952). By comparing and contrasting both countries in terms of non-hegemonic masculinities of the protagonist characters, the pattern of masculinities of each nation, which is often overlooked,  can be explainable. We can identify variations of masculinities in classic fiction, which reflect the national discourses. By utilizing the notion of focalization, the method of narratology can locate the power relation and agency in the story. Post-war anxiety as well as the ideology of fatherism and momism constructs the national gendered discoures. Indonesia’s masculinity resists the legitimate and privileged as well as the status-quo concept of national masculinity. The resistance implies that Indonesia’s national masculinity is more diverse and progressive than America’s is.
Identificação de áreas quentes de desmatamento no cerrado por meio do estimador de densidade kernel
Authors: Silva Yan Breno Azeredo Gomes da
Published: December 2023

A expansão do agronegócio no Brasil, embora crucial para a economia, pode ter consequências ambientais significativas. Esse impacto é evidente em MATOPIBA, uma região que se destaca como a nova fronteira agrícola do Cerrado, caracterizada por altas taxas de desmatamento. Nesse contexto, o objetivo deste estudo foi o de identificar e analisar os registros de desmatamento nas microrregiões de Gerais das Balsas e Barreiras, em MATOPIBA. Para isso, foram utilizados dados do PRODES do Cerrado e do TerraClass, submetidos a etapas de pré-processamento e geoprocessamento. A técnica de interpolação da nuvem de pontos com o estimador de densidade kernel foi empregada para gerar mapas de calor. Os resultados revelaram um aumento progressivo tanto na quantidade de pontos de desmatamento quanto na área desmatada ao longo dos anos analisados. Gerais das Balsas foi a microrregião com maior número de pontos, enquanto Barreiras registrou as maiores áreas desmatadas. As áreas quentes identificadas estão associadas a regiões de vegetação natural, pastagens e áreas próximas a centros urbanos. A intensidade do desmatamento está diretamente relacionada ao uso da terra.
No paraíso terrestre, entre representações e práticas
Authors: Barthe-Deloizy Francine
Published: December 2023

Este trabalho procura mostrar que a observação de lugares e territórios específicos permite uma boa compreensão do sentido da nudez. Nós vamos mostrar como o corpo e a nudez contribuem para definir lugares e territórios, como as representações são a origem destes territórios. O artigo está organizado em três seções: 1. O que é o naturismo e os naturistas? 2. Os valores naturistas estão no centro de um imaginário geográfico. 3. Os lugares para viver uma utopia: uma maneira de se “aposentar” do mundo.
Estimated Savings After Stopping Tyrosine Kinase Inhibitor Treatment Among Patients With Chronic Myeloid Leukemia
Authors: Winn Aaron N. , Atallah Ehab , Cortes Jorge , Deininger Michael W. N. , Kota Vamsi , Larson Richard A. , Moore Joseph O. , Mauro Michael J. , Oehler Vivian G. , Pinilla-Ibarz Javier , Radich Jerald P. , Shah Neil P. , Thompson James E. , Flynn Kathryn E.
Published: December 2023

Importance

Patients with chronic myeloid leukemia (CML) who have a sustained deep molecular response using tyrosine kinase inhibitors (TKIs) can safely attempt to stop their use. As these medications are very costly, this change in treatment protocols may result in large savings.

Objective

To estimate future savings from attempting to stop TKI use among patients with CML who have deep molecular response.

Design, Setting, and Participants

A microsimulation model was developed for this decision analytical modeling study to estimate costs for US adults moving from using a TKI, to attempting discontinuation and then reinitiating TKI therapy, if clinically appropriate. Estimates were calculated for US patients who currently have CML and simulated newly diagnosed cohorts of patients over the next 30 years.

Exposure

Attempting to stop using a TKI.

Main Outcomes and Measures

Estimated savings after attempted discontinuation of TKI use.

Results

A simulated population of individuals with CML in 2018 and future populations were created using estimates from the SEER*Explorer website. The median age at diagnosis was 66 years for men and 65 years for women. Between 2022 and 2052, the savings associated with eligible patients attempting discontinuation of TKI therapy was estimated at more than $30 billion among those currently diagnosed and over $15 billion among those who will develop CML in the future, for a total savings of over $54 billion by 2052 for drug treatment and polymerase chain reaction testing. The estimate is conservative as it does not account for complications and other health care–associated costs for patients continuing TKI therapy.

Conclusions and Relevance

The findings of this decision analytical modeling study of patients with CML suggest that attempting discontinuation of TKI therapy could save over $54 billion during the next 30 years. Further education for patients and physicians is needed to safely increase the number of patients who can successfully attain treatment-free remission.
Trends by Acuity for Emergency Department Visits and Hospital Admissions in California, 2012 to 2022
Authors: Ruxin Talia , Feldmeier Madeline , Addo Newton , Hsia Renee Y.
Published: December 2023

This cohort study investigates trends in emergency department (ED) visits and hospital admissions from EDs in California by visit acuity from 2012 to 2022.
Direct to Consumer Biomarker Testing for Alzheimer Disease—Are We Ready for the Insurance Consequences?
Authors: Arias Jalayne J. , Manchester Margaret , Lah James
Published: December 2023

This Viewpoint discusses direct-to-consumer biomarker tests for Alzheimer disease and their implications on future insurance coverage.
Associations Between Thiazolidinediones Use and Incidence of Rheumatoid Arthritis: A Retrospective Population‐Based Cohort Study
Authors: Zhao Houyu , Chen Xiaowei , Sun Yexiang , Shen Peng , Lin Hongbo , Sun Feng , Zhan Siyan
Published: December 2023

Objective

Preclinical studies suggest that thiazolidinediones (TZDs) may have a protective effect on rheumatoid arthritis (RA), but evidence from population‐based studies is scarce. This study aimed to assess the association between use of TZDs and incidence of RA in a retrospective cohort of patients with type 2 diabetes mellitus (T2DM).

Methods

A retrospective cohort of patients with T2DM who were new users of TZDs or alpha glucosidase inhibitors (AGIs) was assembled. We applied the inverse probability of treatment weighted Cox model to estimate the hazard ratio (HR) of RA incidence associated with the use of TZDs compared with AGIs.

Results

The final analysis included 56,796 new users of AGIs and 14,892 new users of TZDs. The incidence of RA was 187.4 and 135.2 per 100,000 person‐years in AGI users and TZD users, respectively. Compared with use of AGIs, TZD use was associated with a reduction in RA incidence, with an HR of 0.72 (95% confidence interval [95% CI] 0.59–0.89). HRs for cumulative use of TZDs for 0.51 to 4.0 years and more than 4 years with incidence of RA were 0.55 (95% CI 0.35–0.88) and 0.74 (95% CI 0.57–0.98), respectively. Various subgroup analyses and sensitivity analyses were consistent with the primary analysis.

Conclusion

Use of TZDs is associated with a decreased risk of incident RA in patients with T2DM.
Top‐Down Electrochemical Synthesis of Nanoporous Metal Nanosheets from Nonlayered Alloy Precursors
Authors: Chatterjee Swarnendu , Gawas Ramchandra , Snyder Joshua
Published: December 2023

Two‐dimensional (2D) nanomaterials are an attractive class of multifunctional materials owing to their unique chemical, electronic, and structural properties. Bottom‐up formation of 2D nanomaterials (solution processing, atomic‐layer deposition, chemical vapor deposition, etc.) affords direct control of material morphology and chemistry, tailoring their exhibited physicochemical properties. These methodologies, however, have limited throughput. The reduced output and expense of these bottom‐up methodologies limit their economic viability for mass production of multifunctional 2D nanomaterials. Top‐down approaches, through either exfoliation/delamination of a layered material or initiated targeted removal of a sacrificial component, are much more amenable to high production rates. Herein a unique electrochemical dealloying protocol is presented and analyzed for the synthesis of nanoporous iridium nanosheets (npIrx‐NS) from nonlayered, homogeneous alloy precursors. Through observations of combinatory effects of dealloying electrolyte and precursor alloy compositions, insights into the mechanism of formation and evolution of nanoporosity in free‐standing 2D flakes are gained.