bluuebunny/crossref_metadata_2025 huggingface dataset:
A “Superaerophobic” Se-Doped CoS2 Porous Nanowires Array for Cost-Saving Hydrogen Evolution
Authors: Tan Yan , Yin Yijun , Yin Xianhong , Lan Chenghao , Wang Yu , Hu Feilong , Huang Qin , Mi Yan
Published: January 2021

The pursuit of low-cost and high-efficiency catalyst is imperative for the development and utilization of hydrogen energy. Heteroatomic doping which is conducive to the redistribution of electric density is one of the promising strategies to improve catalytic activity. Herein, the Se-doped CoS2 porous nanowires array with a superaerophobic surface was constructed on carbon fiber. Due to the electronic modulation and the unique superaerophobic structure, it showed improved hydrogen evolution activity and stability in urea-containing electrolyte. At a current density of 10 mA cm−2, the overpotentials are 188 mV for hydrogen evolution reaction (HER) and 1.46 V for urea oxidation reaction (UOR). When it was set as a cell, the voltage is low as 1.44 V. Meanwhile, the current densities of HER and UOR, as well as of cell remained basically unchanged after a continuous operation for 48 h. This work opens up a new idea for designing of cost-saving hydrogen evolution electrocatalysts.
Cytokine-Coding Oncolytic Adenovirus TILT-123 Is Safe, Selective, and Effective as a Single Agent and in Combination with Immune Checkpoint Inhibitor Anti-PD-1
Authors: Havunen Riikka , Kalliokoski Riikka , Siurala Mikko , Sorsa Suvi , Santos João M. , Cervera-Carrascon Victor , Anttila Marjukka , Hemminki Akseli
Published: January 2021

Oncolytic viruses provide a biologically multi-faceted treatment option for patients who cannot be cured with currently available treatment options. We constructed an oncolytic adenovirus, TILT-123, to support T-cell therapies and immune checkpoint inhibitors in solid tumors. Adenoviruses are immunogenic by nature, are easy to produce in large quantities, and can carry relatively large transgenes. They are the most commonly used gene therapy vectors and are well tolerated in patients. TILT-123 expresses two potent cytokines, tumor necrosis factor alpha and interleukin-2, to stimulate especially the T-cell compartment in the tumor microenvironment. Before entering clinical studies, the safety and biodistribution of TILT-123 was studied in Syrian hamsters and in mice. The results show that TILT-123 is safe in animals as monotherapy and in combination with an immune checkpoint inhibitor anti-PD-1. The virus treatment induces acute changes in circulating immune cell compartments, but the levels return to normal by the middle of the treatment period. The virus is rapidly cleared from healthy tissues, and it does not cause damage to vital organs. The results support the initiation of a phase 1 dose-escalation trial, where melanoma patients receiving a tumor-infiltrating lymphocyte therapy are treated with TILT-123 (NCT04217473).
A Novel Multi-Ionophore Approach for Potentiometric Analysis of Lanthanide Mixtures
Authors: Ashina Julia , Babain Vasily , Kirsanov Dmitry , Legin Andrey
Published: January 2021

This work aims to discuss quantification of rare earth metals in a complex mixture using the novel multi-ionophore approach based on potentiometric sensor arrays. Three compounds previously tested as extracting agents in reprocessing of spent nuclear fuel were applied as ionophores in polyvinyl chloride (PVC)-plasticized membranes of potentiometric sensors. Seven types of sensors containing these ionophores were prepared and assembled into a sensor array. The multi-ionophore array performance was evaluated in the analysis of Ln3+ mixtures and compared to that of conventional monoionophore sensors. It was demonstrated that a multi-ionophore array can yield RMSEP (root mean-squared error of prediction) values not exceeding 0.15 logC for quantification of individual lanthanides in binary mixtures in a concentration range 5 to 3 pLn3+.
Combining Deroofing with LAight® Therapy for Long-Term Disease Control of Hurley Stage II Hidradenitis Suppurativa: Case Report
Authors: Schultheis Michael , Scheuern Margot , Radkov Ivan
Published: January 2021

There is an increasing consensus that the treatment of Hidradenitis suppurativa (HS) significantly varies with the degree of inflammation and that treatment according to guidelines is not always successful. Here, we report the case of a 31-year-old male with widespread, highly inflammatory Hurley Stage II HS in multiple locations who failed to respond to any kind of established medical treatment, including biologics. As an alternative approach, Ustekinumab was maintained, and additionally the patient was treated with LAight therapy, a combination of intense pulsed light and radiofrequency. After 10 sessions, deroofing of multiple lesions was performed in a two-step process. After a few weeks of healing time accompanied by specialized wound experts, the patient continued with LAight therapy to control and prevent recurrence. This case shows that the combination of LAight therapy and deroofing is a promising treatment plan for the long-term symptom control of mild and moderate HS.
Revisiting the Homogenized Lattice Boltzmann Method with Applications on Particulate Flows
Authors: Trunk Robin , Weckerle Timo , Hafen Nicolas , Thäter Gudrun , Nirschl Hermann , Krause Mathias J.
Published: January 2021

The simulation of surface resolved particles is a valuable tool to gain more insights in the behaviour of particulate flows in engineering processes. In this work the homogenized lattice Boltzmann method as one approach for such direct numerical simulations is revisited and validated for different scenarios. Those include a 3D case of a settling sphere for various Reynolds numbers. On the basis of this dynamic case, different algorithms for the calculation of the momentum exchange between fluid and particle are evaluated along with different forcing schemes. The result is an updated version of the method, which is in good agreement with the benchmark values based on simulations and experiments. The method is then applied for the investigation of the tubular pinch effect discovered by Segré and Silberberg and the simulation of hindered settling. For the latter, the computational domain is equipped with periodic boundaries for both fluid and particles. The results are compared to the model by Richardson and Zaki and are found to be in good agreement. As no explicit contact treatment is applied, this leads to the assumption of sufficient momentum transfer between particles via the surrounding fluid. The implementations are based on the open-source C++ lattice Boltzmann library OpenLB.
Synthesis, Structure and In Vitro Anticancer Activity of Pd(II) Complex of Pyrazolyl-s-Triazine Ligand; A New Example of Metal-Mediated Hydrolysis of s-Triazine Pincer Ligand
Authors: Lasri Jamal , Haukka Matti , Al-Rasheed Hessa H. , Abutaha Nael , El-Faham Ayman , Soliman Saied M.
Published: January 2021

The square planar complex [Pd(PT)Cl(H2O)]*H2O (HPT: 6-(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine-2,4(1H,3H)-dione) was obtained by the reaction of 2-methoxy-4,6-bis(3,5-dimethyl-1H-pyrazol-1-yl)-1,3,5-triazine (MBPT) pincer ligand with PdCl2 in a molar ratio (1:1) under thermal conditions and using acetone as a solvent. The reaction proceeded via C-N cleavage of one C-N moiety that connects the pyrazole and s-triazine combined with the hydrolysis of the O-CH3 group. The reaction of the chloride salt of its higher congener (PtCl2) gave [Pt(3,5-dimethyl-1H-pyrazole)2Cl2]. The crystal structure of [Pd(PT)Cl(H2O)]*H2O complex is stabilized by inter- and intra-molecular hydrogen bonding interactions. Hirshfeld analysis revealed that the H...H (34.6%), O...H (23.6%), and Cl...H (7.8%) interactions are the major contacts in the crystal. The charges at Pd, H2O, Cl and PT are changed to 0.4995, 0.2216, −0.4294 and −0.2917 instead of +2, 0, −1 and −1, respectively, using the MPW1PW91 method. [Pd(PT)Cl(H2O)]*H2O complex has almost equal activities against MDA-MB-231 and MCF-7 cell lines with IC50 of 38.3 µg/mL.
Terahertz Optical Properties of KTiOPO4 Crystal in the Temperature Range of (−192)–150 °C
Authors: Rybak Alina , Antsygin Valery , Mamrashev Alexander , Nikolaev Nazar
Published: January 2021

This paper presents the results of an experimental study of the optical properties of highly resistive monocrystals of potassium titanyl phosphate (KTiOPO4, KTP) in the frequency range of 0.2–1 THz and the temperature range of (−192)–150 °C. The dispersion of the refractive indices is approximated in the form of Sellmeier equations. The results show that the temperature dependence of the Sellmeier coefficients for all three principal optical axes is close to linear and, most likely, does not experience an extremum in the vicinity of the activation temperatures of the cationic conductivity of the KTP crystal at (−73)–(−23) °C. Weak frequency dependence of an optical axis direction angle VZ in the range of 0.2–1 THz is confirmed. However, the change in VZ with temperature is three times higher than reported before.
Detection of Tumor-Specific PTPmu in Gynecological Cancer and Patient Derived Xenografts
Authors: Vincent Jason , Craig Sonya E. L. , Johansen Mette L. , Narla Jyosthna , Avril Stefanie , DiFeo Analisa , Brady-Kalnay Susann M.
Published: January 2021

Background: We developed a fluorophore-conjugated peptide agent, SBK4, that detects a tumor-specific proteolyzed form of the cell adhesion molecule, PTPmu, found in the tumor microenvironment. We previously demonstrated its tissue specific distribution in high-grade brain tumors. To extend those studies to other aggressive solid tumor types, we assessed the tissue distribution of PTPmu/SBK4 in a set of matched gynecologic cancer patient derived xenografts (PDXs) and primary patient tumors, as well as a limited cohort of tumors from gynecological cancer patients. PDXs isolated from the tissues of cancer patients have been shown to yield experimentally manipulatable models that replicate the clinical characteristics of individual patients’ tumors. In this study, gynecological cancer PDXs and patient biopsies were examined to determine if tumor-specific proteolyzed PTPmu was present. Methods: We used the peptide agent SBK4 conjugated to the fluorophore Texas Red (TR) to label tumor tissue microarrays (TMAs) containing patient and/or PDX samples from several high-grade gynecologic cancer types, and quantified the level of staining with Image J. In one TMA, we were able to directly compare the patient and the matched PDX tissue on the same slide. Results: While normal tissue had very little SBK4-TR staining, both primary tumor tissue and PDXs have higher labeling with SBK4-TR. Matched PDXs and patient samples from high-grade endometrial and ovarian cancers demonstrated higher levels of PTPmu by staining with SBK4 than normal tissue. Conclusion: In this sample set, all PDXs and high-grade ovarian cancer samples had increased labeling by SBK4-TR compared with the normal controls. Our results indicate that proteolyzed PTPmu and its novel peptide detection agent, SBK4, allow for the visualization of tumor-specific changes in cell adhesion molecules by tissue-based staining, providing a rationale for further development as an imaging agent in aggressive solid tumors, including gynecological cancers.
Entropy Generation for Negative Frictional Pressure Drop in Vertical Slug and Churn Flows
Authors: Liu Lei , Liu Dongxu , Huang Na
Published: January 2021

It is widely accepted that the frictional pressure drop is impossible to be negative for pipe flow. However, the negative frictional pressure drops were observed for some cases of two-phase slug and churn flows in pipes, challenging the general sense of thermodynamic irreversibility. In order to solve this puzzling problem, theoretical investigations were performed for the entropy generation in slug and churn flows. It is found that the frictional pressure drop along with a buoyancy-like term contributes to the entropy generation due to mechanical energy loss for steady, incompressible slug and churn flows in vertical and inclined pipes. Experiments were conducted in a vertical pipe with diameter as 0.04 m for slug and churn flows. Most of the experimental data obtained for frictional pressure drop are negative at high gas–liquid ratios from 100 to 10,000. Entropy generation rates were calculated from experimental data. The results show that the buoyancy-like term is positive and responsible for a major part of entropy generation rate while the frictional pressure drop is responsible for a little part of entropy generation rate, because of which the overall entropy generation due to mechanical energy loss is still positive even if the frictional pressure drop is negative in vertical slug and churn flows. It is clear that the negative frictional pressure drops observed in slug and churn flows are not against the thermodynamics irreversibility.
Reference Power Supply Connection Scheme for Low-Power CMOS Image Sensors Based on Incremental Sigma-Delta Converters
Authors: Carvalho Freitas Luis Miguel , Morgado-Dias Fernando
Published: January 2021

Modern Complementary Metal-Oxide-Semiconductor (CMOS) image sensors, aimed to target low-noise and fast digital outputs, are fundamentally based on column-parallel structures, jointly designed with oversampling column converters. The typical choice for the employed column converters is the incremental sigma-delta structures, which intrinsically perform the correlated multiple sampling, creating an averaging effect over the system thermal noise when used in conjunction with 4T-pinned pixels. However, these types of column converters are known to be power-hungry, especially if the imaging device needs to target high frame rate levels as well. In this sense, the aim of this paper was to address the excess of power dissipation problem that arises from image sensors while employing oversampling high-order incremental converters, by means of using a different connection scheme to supply and to drive the required reference signals across the image sensor on-chip column converters. The proposed connection scheme revealed to be fully functional with no unwanted artifacts in the imager output response, allowing it to avoid 20% to 50% of the power dissipation, relative to the classical on-chip references generation and driving method. Furthermore, this solution allows for a much less complicated and less crowded printed circuit board (PCB) system.
Constructing Emotional Machines: A Case of a Smartphone-Based Emotion System
Authors: Lin Hao-Chiang Koong , Ma Yu-Chun , Lee Min
Published: January 2021

In this study, an emotion system was developed and installed on smartphones to enable them to exhibit emotions. The objective of this study was to explore factors that developers should focus on when developing emotional machines. This study also examined user attitudes and emotions toward emotional messages sent by machines and the effects of emotion systems on user behavior. According to the results of this study, the degree of attention paid to emotional messages determines the quality of the emotion system, and an emotion system triggers certain behaviors in users. This study recruited 124 individuals with more than one year of smartphone use experience. The experiment lasted for two weeks, during which time participants were allowed to operate the system freely and interact with the system agent. The majority of the participants took interest in emotional messages, were influenced by emotional messages and were convinced that the developed system enabled their smartphone to exhibit emotions. The smartphones generated 11,264 crucial notifications in total, among which 76% were viewed by the participants and 68.1% enabled the participants to resolve unfavorable smartphone conditions in a timely manner and allowed the system agent to provide users with positive emotional feedback.
The Assessment of Autoignition of Modified Jet Fuels
Authors: Merkisz Jerzy , Pielecha Ireneusz , Łęgowik Anna
Published: January 2021

The condition of the natural environment, including breathable air, indicates that actions are to be taken related to the reduction of exhaust emissions from transport. One of the sectors of transport is aviation. The reduction of emissions is tightly related to the types of fuels in this sector of transport. In the paper, the authors propose the application of a new generation of jet fuels. A full exploration of the physicochemical properties of these fuels requires research under actual engine operation. The conducted research pertains to the autoignition of modified jet fuels in terms of the thermodynamic indicators and optical analyses of the early phase of flame development. The investigations were conducted using a Rapid Compression Expansion Machine with a simultaneous recording of images using a high-speed camera. Owing to this technique, the authors could assess the thermodynamic properties and analyze the early flame development processes. The investigations enabled the assessment of fuel properties indicating an increased delay of the autoignition process compared to the reference fuel (diesel fuel). The performed analyses have confirmed a huge role of modern fuels (including HEFA in particular) in contemporary aviation–significant delay of autoignition at a simultaneous significant formation of autoignition spots and high intensification of combustion.
Impact of the COVID-19 Lockdown on the Electricity System of Great Britain: A Study on Energy Demand, Generation, Pricing and Grid Stability
Authors: Kirli Desen , Parzen Maximilian , Kiprakis Aristides
Published: January 2021

The outbreak of SARS-COV-2 disease 2019 (COVID-19) abruptly changed the patterns in electricity consumption, challenging the system operations of forecasting and balancing supply and demand. This is mainly due to the mitigation measures that include lockdown and work from home (WFH), which decreased the aggregated demand and remarkably altered its profile. Here, we characterise these changes with various quantitative markers and compare it with pre-lockdown business-as-usual data using Great Britain (GB) as a case study. The ripple effects on the generation portfolio, system frequency, forecasting accuracy and imbalance pricing are also analysed. An energy data extraction and pre-processing pipeline that can be used in a variety of similar studies is also presented. Analysis of the GB demand data during the March 2020 lockdown indicates that a shift to WFH will result in a net benefit for flexible stakeholders, such as consumers on variable tariffs. Furthermore, the analysis illustrates a need for faster and more frequent balancing actions, as a result of the increased share of renewable energy in the generation mix. This new equilibrium of energy demand and supply will require a redesign of the existing balancing mechanisms as well as the longer-term power system planning strategies.
An eDrive-Based Estimation Method of the Laundry Unbalance and Laundry Inertia for Washing Machine Applications
Authors: Martinello Daniele , Rubino Sandro , Bojoi Radu
Published: January 2021

The estimation of the laundry unbalance and laundry inertia is fundamental in washing machine applications. On the one hand, the estimation and management of the laundry unbalance play a pivotal role in reducing mechanical stress and noise during the spinning phase. On the other hand, the laundry inertia’s estimation, performed at the beginning of the washing cycle, allows for the determination of the proper amounts of water and detergent, the water temperature, and the tumbling time. In this way, good washing performance is obtained, avoiding the waste of energy and resources. Moreover, at the end of the washing cycle, the laundry inertia’s accurate estimation is needed to properly manage the spinning phase. With the aim of optimizing the washing performance, this paper proposes a novel method to estimate the laundry unbalance and laundry inertia. The proposed approach does not require additional sensors, since it uses the already implemented motor control scheme, enhanced by a dedicated position-tracking observer. Experimental results have been carried out on a commercial horizontal-axis direct-drive washer, demonstrating the validity of the proposed solution.
A Computational Fluid Dynamics Model for a Water Vortex Power Plant as Platform for Etho- and Ecohydraulic Research
Authors: Powalla Dennis , Hoerner Stefan , Cleynen Olivier , Müller Nadine , Stamm Jürgen , Thévenin Dominique
Published: January 2021

The objective of the present paper is to develop a validated numerical model of a water vortex power plant that serves as a digital twin for further studies such as assessments of the ethohydraulic characteristics or the performance of such devices. The reference for the validation process is a large-scale hydraulic installation equipped with a full-scale water vortex power plant prototype installed in Dresden (Germany), where flow field measurements were carried out using three-dimensional Acoustic Doppler Velocimetry. The numerical model was implemented within the software package Star-CCM+. The unsteady, two-phase flow was solved with the Reynolds-Averaged Navier–Stokes equations in a Eulerian Multiphase approach, deploying a Volume of Fluid method to describe the free-surface flow. Water level and flow velocities were systematically compared in key areas of the device, demonstrating that the simulation is in good agreement with experimental observations. Relative differences are limited to at most 4% regarding water height in the system, and even the much more challenging velocity fields are reproduced with typical relative errors of roughly 10%. This validates the ability of the model to model the challenging flow conditions found in a water vortex power plant, enabling subsequent studies of the characteristics of this power plant concerning fish migration.
An Investigation of the Potential Adoption of Anaerobic Digestion for Energy Production in Irish Farms
Authors: O’Connor Sean , Ehimen Ehiaze , Pillai Suresh , Power Niamh , Lyons Gary , Bartlett John
Published: January 2021

Anaerobic digestion (AD) has been recognised as an effective means of simultaneously producing energy while reducing greenhouse gas (GHG) emissions. Despite having a large agriculture sector, Ireland has experienced little uptake of the technology, ranking 20th within the EU-28. It is, therefore, necessary to understand the general opinions, willingness to adopt, and perceived obstacles of potential adopters of the technology. As likely primary users of this technology, a survey of Irish cattle farmers was conducted to assess the potential of on-farm AD for energy production in Ireland. The study seeks to understand farmers’ motivations, perceived barriers, and preferred business model. The study found that approximately 41% of the 91 respondents were interested in installing AD on their farming enterprise within the next five years. These Likely Adopters tended to have a higher level of education attainment, and together, currently hold 4379 cattle, potentially providing 37,122 t year−1 of wastes as feedstock, resulting in a potential CO2 reduction of 800.65 t CO2-eq. year−1. Moreover, the results indicated that the primary consideration preventing the implementation of AD is a lack of information regarding the technology and high investment costs. Of the Likely Adopters and Possible Adopters, a self-owned and operated plant was the preferred ownership structure, while 58% expressed an interest in joining a co-operative scheme. The findings generated provide valuable insights into the willingness of farmers to implement AD and guidance for its potential widespread adoption.
Physiological and Regenerative Plant Traits Explain Vegetation Regeneration under Different Severity Levels in Mediterranean Fire-Prone Ecosystems
Authors: Huerta Sara , Fernández-García Víctor , Marcos Elena , Suárez-Seoane Susana , Calvo Leonor
Published: January 2021

In Mediterranean fire-prone ecosystems, plant functional traits and burn severity have decisive roles in post-fire vegetation recovery. These traits may reflect plant fitness to fire regimes in the Mediterranean Basin. The aim of this study was to evaluate the effect of burn severity on post-fire vegetation regeneration through plant functional (physiological and regenerative) traits in two Mediterranean ecosystems: one more humid and colder (Cabrera in León province, NW Spain), and another characterized by a longer summer drought (Gátova in Valencia province, SE Spain). A total of 384 and 80 field plots (2 m × 2 m) were fixed in Cabrera and Gátova, respectively. In each burned plot, we quantified burn severity by means of the composite burn index (CBI), differentiating three severity levels (low, moderate, and high), and evaluated post-fire vegetation regeneration one and two years after wildfires. We measured the percentage cover of each species and classified them according to physiological (specific leaf area and N2-fixing capacity) and regenerative traits (reproductive strategy, bud bank location, and heat-stimulated germination). The main results showed that in Cabrera, burn severity had significant effects on vegetation cover independently of plant functional traits. In Gátova, burn severity effects differed among functional traits. In this site, the cover of plants with low specific leaf area and without heat-stimulation and N2-fixing capacity was negatively related to burn severity. On the contrary, the cover of N2-fixers and species with resprouting ability and heat-stimulated germination rose with increasing burn severity. In general, vegetation cover showed a more pronounced increased over time in the more humid area, mainly under the effect of high severity. The results of this research highlighted the importance of the use of plant functional traits as a driver to understand the response of different ecosystems to current fire regimes, which could be relevant for pre- and post-fire management.
Evaluating the Effect of Lignocellulose-Derived Microbial Inhibitors on the Growth and Lactic Acid Production by Bacillus coagulans Azu-10
Authors: Abdel-Rahman Mohamed Ali , Hassan Saad El-Din , Fouda Amr , Radwan Ahmed A. , Barghoth Mohammed G. , Desouky Salha G.
Published: January 2021

Effective lactic acid (LA) production from lignocellulosic biomass materials is challenged by several limitations related to pentose sugar utilization, inhibitory compounds, and/or fermentation conditions. In this study, a newly isolated Bacillus coagulans strain Azu-10 was obtained and showed homofermentative LA production from xylose with optimal fermentation conditions at 50 °C and pH 7.0. Growth of strain Azu-10 and LA-fermentation efficiency were evaluated in the presence of various lignocellulose-derived inhibitors (furans, carboxylic acids, and phenols) at different concentrations. Furanic lignocellulosic-derived inhibitors were completely detoxified. The strain has exhibited high biomass, complete xylose consumption, and high LA production in the presence of 1.0–4.0 g/L furfural and 1.0–5.0 g/L of hydroxymethyl furfural, separately. Moreover, strain Azu-10 exhibited high LA production in the presence of 5.0–15.0 g/L acetic acid, 5.0 g/L of formic acid, and up to 7.0 g/L of levulinic acid, separately. Besides, for phenolic compounds, p-coumaric acid was most toxic at 1.0 g/L, while syringaldehyde or p-hydroxybenzaldehyde, and vanillin at 1.0 g/L did not inhibit LA fermentation. The present study provides an interesting potential candidate for the thermophilic LA fermentation from lignocellulose-derived substrates at the industrial biorefinery level.
The Application of Pureed Butter Beans and a Combination of Inulin and Rebaudioside A for the Replacement of Fat and Sucrose in Sponge Cake: Sensory and Physicochemical Analysis
Authors: Richardson Aislinn M. , Tyuftin Andrey A. , Kilcawley Kieran N. , Gallagher Eimear , O’Sullivan Maurice G. , Kerry Joseph P.
Published: January 2021

Determining minimum levels of fat and sucrose needed for the sensory acceptance of sponge cake while increasing the nutritional quality was the main objective of this study. Sponge cakes with 0, 25, 50 and 75% sucrose replacement (SR) using a combination of inulin and Rebaudioside A (Reb A) were prepared. Sensory acceptance testing (SAT) was carried out on samples. Following experimental results, four more samples were prepared where fat was replaced sequentially (0, 25, 50 and 75%) in sucrose-replaced sponge cakes using pureed butter beans (Pbb) as a replacer. Fat-replaced samples were investigated using sensory (hedonic and intensity) and physicochemical analysis. Texture liking and overall acceptability (OA) were the only hedonic sensory parameters significantly affected after a 50% SR in sponge cake (p < 0.05). A 25% SR had no significant impact on any hedonic sensory properties and samples were just as accepted as the control sucrose sample. A 30% SR was chosen for further experiments. After a 50% fat replacement (FR), no significant differences were found between 30% sucrose-replaced sponge cake samples in relation to all sensory (hedonic and intensity) parameters investigated. Flavour and aroma intensity attributes such as buttery and sweet and, subsequently, liking and OA of samples were negatively affected after a 75% FR (p < 0.05). Instrumental texture properties (hardness and chewiness (N)) did not discriminate between samples with increasing levels of FR using Pbb. Moisture content increased significantly with FR (p < 0.05). A simultaneous reduction in fat (42%) and sucrose was achieved (28%) in sponge cake samples without negatively affecting OA. Optimised samples contained significantly more dietary fibre (p < 0.05).
Enriched Fresh Pasta with a Sea Bass By-Product, a Novel Food: Fatty Acid Stability and Sensory Properties throughout Shelf Life
Authors: Ainsa Andrea , Marquina Pedro L. , Roncalés Pedro , Beltrán José Antonio , Calanche M. Juan B.
Published: January 2021

A by-product from the filleting of sea bass (Dicentrachus labrax) was used to manufacture enriched pasta. The research aimed at achieving an increase of protein and unsaturated fatty acid contents, making innovative and healthy pasta products that are able to step up fish consumption. Two different kind of cereals were used to make fresh pasta, which were subjected to frozen storage with the addition or not of a rosemary antioxidant. The developed pastas were analyzed by physicochemical methods. Proximal analysis demonstrated an improvement of nutritional values on those of a common pasta. Fatty acid profiles, acidity indices, and TBARS (Thiobarbituric acid reactive substances) index confirmed the stability of fat and effective protection against oxidation, especially in pasta with added antioxidant. The cooking time for pasta was set at 90 s, and color parameters were modified due to the incorporation of fish in the pasta-making process. An enrichment in fatty acids ω-3 and ω-6 was also confirmed. The conversion of α-linolenic acid (ALA) in eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) in frozen storage was detected, which remained stable during 90 days. Finally, sensory profiles of enriched pasta were found to be adequate and improved following the addition of an antioxidant due to a decrease of negative attributes associated with oxidation.
Calcium Chelation by Phosphate Ions and Its Influence on Fouling Mechanisms of Whey Protein Solutions in a Plate Heat Exchanger
Authors: Scudeller Luisa A. , Blanpain-Avet Pascal , Six Thierry , Bellayer Séverine , Jimenez Maude , Croguennec Thomas , André Christophe , Delaplace Guillaume
Published: January 2021

Fouling of plate heat exchangers (PHEs) is a recurring problem when pasteurizing whey protein solutions. As Ca2+ is involved in denaturation/aggregation mechanisms of whey proteins, the use of calcium chelators seems to be a way to reduce the fouling of PHEs. Unfortunately, in depth studies investigating the changes of the whey protein fouling mechanism in the presence of calcium chelators are scarce. To improve our knowledge, reconstituted whey protein isolate (WPI) solutions were prepared with increasing amounts of phosphate, expressed in phosphorus (P). The fouling experiments were performed on a pilot-scale PHE, while monitoring the evolution of the pressure drop and heat transfer coefficient. The final deposit mass distribution and structure of the fouling layers were investigated, as well as the whey protein denaturation kinetics. Results suggest the existence of two different fouling mechanisms taking place, depending on the added P concentration in WPI solutions. For added P concentrations lower or equal to 20 mg/L, a spongy fouling layer consists of unfolded protein strands bound by available Ca2+. When the added P concentration is higher than 20 mg/L, a heterogeneously distributed fouling layer formed of calcium phosphate clusters covered by proteins in an arborescence structure is observed.
Methods for Testing the Quality Attributes of Plant-Based Foods: Meat- and Processed-Meat Analogs
Authors: McClements David Julian , Weiss Jochen , Kinchla Amanda J. , Nolden Alissa A. , Grossmann Lutz
Published: January 2021

The modern food system is seeing a change in consumption patterns provoked by several drivers—including ethical, health, and environmental concerns—that are increasing the sales of meat analog foods. This change is accompanied by increased research and development activities in the area of plant-based meats. The aim of the present review is to describe methods that are being employed by scientists to analyze and characterize the properties of meat alternatives and to propose standardized methods that could be utilized in the future. In particular, methods to determine the proximate composition, microstructure, appearance, textural properties, water-holding properties, cooking resilience, and sensory attributes, of plant-based meat are given. The principles behind these methods are presented, their utility is critically assessed, and practical examples will be discussed. This article will help to guide further studies and to choose appropriate methods to assess raw materials, processes, products, and consumption behavior of meat analogs.
Children’s Fruit and Vegetable Preferences Are Associated with Their Mothers’ and Fathers’ Preferences
Authors: Kähkönen Kaisa , Sandell Mari , Rönkä Anna , Hujo Mika , Nuutinen Outi
Published: January 2021

Children’s preference for fruit and vegetables must emerge during childhood. At children’s homes, mothers and fathers influence children’s developing food preferences with their own preferences and actions. The purpose of the study was to reveal the association parents have with their children’s fruit and vegetable preferences. The study was conducted in a sample of Finnish mothers and fathers of 3–5-year-old children. The participants were recruited, and questionnaires distributed through early childhood education and care centers in 2014 and 2015. The results showed considerable variance in the children’s preferences, and were more similar with their father’s, than their mother’s preference. There was an association between mother’s and children’s preference for “strong-tasting vegetables and berries“ (p = 0.005), “sweet-tasting fruit“ (p < 0.001) and “common vegetables“ (p = 0.037). Fathers preferences associated with children’s preferences for “strong-tasting vegetables and berries“ (p = 0.003). Food neophobia decreased children’s “strong-tasting vegetables and berries“ (p < 0.001) and “sweet-tasting fruit“ (p < 0.001) preferences. The father’s more relaxed attitude towards eating decreased children’s preferences for “strong-tasting vegetables and berries“ (p = 0.031) and “sweet-tasting fruit“ (p = 0.003). These findings indicate a need for more targeted strategies for increasing children’s preferences for fruit and vegetables and highlight the importance of taking both parents equally into account.
Quality of Dabai Pulp Oil Extracted by Supercritical Carbon Dioxide and Supplementation in Hypercholesterolemic Rat—A New Alternative Fat
Authors: Kadir Noor Atiqah Aizan Abdul , Azlan Azrina , Abas Faridah , Ismail Intan Safinar
Published: January 2021

Dabai pulp oil (DPO) is new oil extracted from the pulp of Canarium odontophyllum. The quality and efficacy of DPO are needed to promote its potential as a new alternative fat. Therefore, we investigate the quality of DPO, which includes moisture and volatile content (MVC), free fatty acid content (FFA), iodine value (IV), and peroxide value (PV). Furthermore, we evaluate the efficacy of DPO against hypercholesterolemia elicited by a high-cholesterol diet in rats. The MVC of DPO was <0.001 ± 0.00%. Next, the FFA in DPO was 2.57 ± 0.03%, and the IV of DPO was 53.74 ± 0.08 g iodine/100 g oil. Meanwhile, the PV of DPO was 4.97 ± 0.00 mEq/kg. Supplementation of DPO in hypercholesterolemic rats for 30 days revealed the hypocholesterolemic effect (significant reduction of total cholesterol, triglyceride, and 3-hydroxy-3-methylglutaryl-CoA reductase) accompanied by a significant reduction of inflammatory markers (C-reactive protein, interleukin-6 and tumour necrosis factor-α), and lipid peroxidation (MDA). We also observed a significant improvement of lipoprotein lipase (LPL) and antioxidant capacities (total antioxidant status, superoxide dismutase, glutathione peroxidase, and catalase) of the rats. The results on the quality and efficacy of locally made DPO suggest its potential use as a healthy alternative fat in the future.
Genes and SNPs Involved with Scrotal and Umbilical Hernia in Pigs
Authors: Rodrigues Ariene Fernanda Grando , Ibelli Adriana Mércia Guaratini , Peixoto Jane de Oliveira , Cantão Maurício Egídio , Oliveira Haniel Cedraz de , Savoldi Igor Ricardo , Souza Mayla Regina , Mores Marcos Antônio Zanella , Carreño Luis Orlando Duitama , Ledur Mônica Corrêa
Published: January 2021

Hernia is one of the most common defects in pigs. The most prevalent are the scrotal (SH), inguinal (IH) and umbilical (UH) hernias. We compared the inguinal ring transcriptome of normal and SH-affected pigs with the umbilical ring transcriptome of normal and UH-affected pigs to discover genes and pathways involved with the development of both types of hernia. A total of 13,307 transcripts was expressed in the inguinal and 13,302 in the umbilical ring tissues with 94.91% of them present in both tissues. From those, 35 genes were differentially expressed in both groups, participating in 108 biological processes. A total of 67 polymorphisms was identified in the inguinal ring and 76 in the umbilical ring tissue, of which 11 and 14 were novel, respectively. A single nucleotide polymorphism (SNP) with deleterious function was identified in the integrin α M (ITGAM) gene. The microtubule associated protein 1 light chain 3 γ (MAP1LC3C), vitrin (VIT), aggrecan (ACAN), alkaline ceramidase 2 (ACER2), potassium calcium-activated channel subfamily M α 1 (KCNMA1) and synaptopodin 2 (SYNPO2) genes are highlighted as candidates to trigger both types of hernia. We generated the first comparative study of the pig umbilical and inguinal ring transcriptomes, contributing to the understanding of the genetic mechanism involved with these two types of hernia in pigs and probably in other mammals.
Autoimmune Polyendocrinopathy–Candidiasis–Ectodermal Dystrophy in Two Siblings: Same Mutations but Very Different Phenotypes
Authors: Carpino Andrea , Buganza Raffaele , Matarazzo Patrizia , Tuli Gerdi , Pinon Michele , Calvo Pier Luigi , Montin Davide , Licciardi Francesco , De Sanctis Luisa
Published: January 2021

Autoimmune polyendocrinopathy–candidiasis–ectodermal dystrophy (APECED), caused by mutations in the AIRE gene, is mainly characterized by the triad of hypoparathyroidism, primary adrenocortical insufficiency and chronic mucocutaneous candidiasis, but can include many other manifestations, with no currently clear genotype–phenotype correlation. We present the clinical features of two siblings, a male and a female, with the same mutations in the AIRE gene associated with two very different phenotypes. Interestingly, the brother recently experienced COVID-19 infection with pneumonia, complicated by hypertension, hypokalemia and hypercalcemia. Although APECED is a monogenic disease, its expressiveness can be extremely different. In addition to the genetic basis, epigenetic and environmental factors might influence the phenotypic expression, although their exact role remains to be elucidated.
Feasibility of Objective Seabed Mapping Techniques in a Coastal Tidal Environment (Wadden Sea, Germany)
Authors: Mascioli Francesco , Piattelli Valerio , Cerrone Francesco , Gasprino Davide , Kunde Tina , Miccadei Enrico
Published: January 2021

The growing interest in monitoring the marine environment has strongly encouraged governmental agencies and research institutes to undertake seabed mapping programs and stimulated scientific interest in innovative mapping methods and tools. In this study, object-based image analysis was used to map a very shallow tidal inlet, characterized by high sediment variability and intense morphodynamic processes. The aim was to test the feasibility of reproducible mapping approaches within extended mapping programs of complex coastal areas. The study is based on full-coverage, high-resolution bathymetry and reflectivity, calibrated by means of sediment samples. Seafloor segmentation and classification were based on a cluster analysis performed on reflectivity, slope, and ruggedness. Statistics of clusters were extracted and analysed to identify the optimal number of clusters and evaluate the suitability of the clustering process to differentiate different seabed types. Clusters and samples data were joined to create a training and validation dataset for characterizing the seabed and carrying out an accuracy assessment. Misclassifications were explored and referred to three main reasons: (i) The not-perfect correspondence between sediment boundaries of classification systems and boundaries derived from the clustering process; (ii) the geomorphological features of the seabed; and (iii) the position accuracy of samples. The study contributes to testing of the feasibility of objective methods and highlights the importance of joining acoustic, lithological, and geomorphological analysis. It highlights issues and the need to critically analyse the mapping results and improve the accuracy of collected data.
Irpinia Earthquake and History: A Nexus as a Problem
Authors: Lombardi Giovanni
Published: January 2021

Forty years from the 23 November 1980, Irpinia-Basilicata earthquake date represents much more than a commemoration. It has been a fracture for the history of Italy. Important for many reasons, this earthquake has been a watershed for the studies and the public role of research. Historians have been solicited to work on the topic by scholars of the geological and seismological sciences: in the face of the repetition of disastrous seismic events in Italy, earthquakes remained ‘outside the history’. However, the real difficulty of socio-historical science is not neglecting seismic events and their consequences, but rather the reluctance to think of ‘earthquake’ as a specific interpretative context. This means to deal with the discipline ‘statute’ as well as the public commitment of scholars. In this way, the circle earthquake-history-memory requires broad interdisciplinarity, which offers insights to work on historical consciousness and cultural memory: important aspects to understand the past as well as to favour a seismic risk awareness.
An Adaptive Inverse-Distance Weighting Interpolation Method Considering Spatial Differentiation in 3D Geological Modeling
Authors: Liu Zhen , Zhang Zhilong , Zhou Cuiying , Ming Weihua , Du Zichun
Published: January 2021

The inverse-distance weighting interpolation is widely used in 3D geological modeling and directly affects the accuracy of models. With the development of “smart” or “intelligent” geology, classical inverse-distance weighting interpolation cannot meet the accuracy, reliability, and efficiency requirements of large-scale 3D geological models in these fields. Although the improved inverse-distance weighting interpolation can basically meet the requirements of accuracy and reliability, it cannot meet the requirements of efficiency at the same time. In response to these limitations, the adaptive inverse-distance weighting interpolation method based on geological attribute spatial differentiation and geological attribute feature adaptation was proposed. This method takes into account the spatial differentiation of geological attributes to improve the accuracy and considers the first-order neighborhood selection strategy to adaptively improve efficiency to meet above requirements of large-scale geological modeling. The proposed method was applied to an area in eastern China, and the results of the proposed method, compared to the results of classical inverse-distance weighting interpolation and improved inverse-distance weighting interpolation, suggest that the problems encountered above in large-scale geological modeling can be solved with the proposed method. The method can provide effective support for large-scale 3D geological modeling in smart geology.
Polydatin Beneficial Effects in Zebrafish Larvae Undergoing Multiple Stress Types
Authors: Pessina Andrea , Di Vincenzo Mariangela , Maradonna Francesca , Marchegiani Francesca , Olivieri Fabiola , Randazzo Basilio , Gioacchini Giorgia , Carnevali Oliana
Published: January 2021

Polydatin is a polyphenol, whose beneficial properties, including anti-inflammatory and antioxidant activity, have been largely demonstrated. At the same time, copper has an important role in the correct organism homeostasis and alteration of its concentration can induce oxidative stress. In this study, the efficacy of polydatin to counteract the stress induced by CuSO4 exposure or by caudal fin amputation was investigated in zebrafish larvae. The study revealed that polydatin can reduced the stress induced by a 2 h exposure to 10 µM CuSO4 by lowering the levels of il1b and cxcl8b.1 and reducing neutrophils migration in the head and along the lateral line. Similarly, polydatin administration reduced the number of neutrophils in the area of fin cut. In addition, polydatin upregulates the expression of sod1 mRNA and CAT activity, both involved in the antioxidant response. Most of the results obtained in this study support the working hypothesis that polydatin administration can modulate stress response and its action is more effective in mitigating the effects rather than in preventing chemical damages.
Machine and Deep Learning towards COVID-19 Diagnosis and Treatment: Survey, Challenges, and Future Directions
Authors: Alafif Tarik , Tehame Abdul Muneeim , Bajaba Saleh , Barnawi Ahmed , Zia Saad
Published: January 2021

With many successful stories, machine learning (ML) and deep learning (DL) have been widely used in our everyday lives in a number of ways. They have also been instrumental in tackling the outbreak of Coronavirus (COVID-19), which has been happening around the world. The SARS-CoV-2 virus-induced COVID-19 epidemic has spread rapidly across the world, leading to international outbreaks. The COVID-19 fight to curb the spread of the disease involves most states, companies, and scientific research institutions. In this research, we look at the Artificial Intelligence (AI)-based ML and DL methods for COVID-19 diagnosis and treatment. Furthermore, in the battle against COVID-19, we summarize the AI-based ML and DL methods and the available datasets, tools, and performance. This survey offers a detailed overview of the existing state-of-the-art methodologies for ML and DL researchers and the wider health community with descriptions of how ML and DL and data can improve the status of COVID-19, and more studies in order to avoid the outbreak of COVID-19. Details of challenges and future directions are also provided.