bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery and Computational Analyses of Novel Small Molecule Zika Virus Inhibitors
Authors: Zhu Siyu , Zhang Chaozai , Huang Lina S. , Zhang Xing-Quan , Xu Yan , Fang Xiong , Zhou Jiao , Wu Meixian , Schooley Robert T. , Huang Ziwei , An Jing
Published: April 2019

Zika virus (ZIKV), one of the flaviviruses, has attracted worldwide attention since its large epidemics around Brazil. Association of ZIKV infection with microcephaly and neurological problems such as Guillain–Barré syndrome has prompted intensive pathological investigations. However, there is still a long way to go on the discovery of effective anti-ZIKV therapeutics. In this study, an in silico screening of the National Cancer Institute (NCI) diversity set based on ZIKV NS3 helicase was performed using a molecular docking approach. Selected compounds with drug-like properties were subjected to cell-based antiviral assays resulting in the identification of two novel lead compounds (named Compounds 1 and 2). They inhibited ZIKV infection with IC50 values at the micro-molar level (8.5 μM and 15.2 μM, respectively). Binding mode analysis, absolute binding free energy calculation, and structure–activity relationship studies of these two compounds revealed their possible interactions with ZIKV NS3 helicase, suggesting a mechanistic basis for further optimization. These two novel small molecules may represent new leads for the development of inhibitory drugs against ZIKV.
Oxytrodiflavanone A and Oxytrochalcoflavanones A,B: New Biflavonoids from Oxytropis chiliophylla
Authors: Liu Yang , Kelsang Norbo , Lu Jianghai , Zhang Yingtao , Liang Hong , Tu Pengfei , Kong Dexin , Zhang Qingying
Published: April 2019

Three previously undescribed biflavonoids, oxytrodiflavanone A (1), and oxytrochalcoflavanones A,B (2,3), were isolated from the aerial part of Oxytropis chiliophylla, together with their putative biosynthetic monomers, i.e., (2S)-5,7-dihydroxyflavanone (4), (2S)-7-hydroxyflavanone (5), and 2′,4′-dihydroxychalcone (6). The structures of these compounds were elucidated by a combination analysis of spectroscopic data. The cytotoxic activities of all the isolated compounds against PC-3 human prostate cancer cell line are also presented.
Formation of Ethyl Carbamate during the Production Process of Cantonese Soy Sauce
Authors: Zhou Kai , Siroli Lorenzo , Patrignani Francesca , Sun Yuanming , Lanciotti Rosalba , Xu Zhenlin
Published: April 2019

The aim of this work was to clarify the formation of ethyl carbamate (EC) and its influence factors throughout the production process of Cantonese soy sauce. The results showed that EC was not detected in the koji-making and early moromi fermentation stages, but started to be generated when pH of the moromi decreased to about 4.9—at the same time, the levels of ethanol, urea and citrulline increased significantly. Most EC was formed during raw soy sauce hot extraction (40.6%) and sterilization (42.9%) stages. The EC content exhibited the highest correlation with ethanol throughout the whole production process (R = 0.97). The simulation soy sauce produced in laboratory led the same conclusion—moreover, the contents of EC, ethanol and citrulline were higher in soy sauce fermented at 30 °C than in soy sauce fermented at 15 °C. Extraction of raw soy sauce by squeezing contributed little to EC formation. Further research showed that citrulline and ethanol led to significant increases in EC levels in raw soy sauce upon heating. These results indicate that ethanol and citrulline are two critical precursors of EC and that EC is mainly formed during the heat treatment stage of soy sauce.
Evaluation of Yeast Derivative Products Developed as an Alternative to Lees: The Effect on the Polysaccharide, Phenolic and Volatile Content, and Colour and Astringency of Red Wines
Authors: Del Barrio-Galán Rubén , Úbeda Cristina , Gil Mariona , Medel-Marabolí Marcela , Sieczkowski Nathalie , Peña-Neira Álvaro
Published: April 2019

Due to the increase of the use of yeast derivatives (YDs) in winemaking to improve the technological and sensory properties in wines, in this work we evaluated the effect of the post-fermentation application of different yeast derivative products on the physical and chemical properties and astringency of red wines during two consecutive harvests. A commercial and two experimental new yeast derivatives were applied at a medium‒high dosage (30 g/hL). The addition of different yeast derivatives in red wine increased the concentration of different polysaccharide fractions and, therefore, the total polysaccharide content, producing a decrease in the duration of the wine astringency perception over time. The use of yeast derivatives could produce an adsorption/clarification and/or protective effect on the phenolic compounds. However, it did not produce an important modification of the colour parameters. An intensification or a lower decrease of the most volatile compound groups was produced, but it depended on the YDs and yeast strain used in fermentation and post-fermentation processes.
Recovering Cucurbita pepo cv. ‘Lungo Fiorentino’ Wastes: UHPLC-HRMS/MS Metabolic Profile, the Basis for Establishing Their Nutra- and Cosmeceutical Valorisation
Authors: Piccolella Simona , Bianco Alessandro , Crescente Giuseppina , Santillo Alessandra , Chieffi Baccari Gabriella , Pacifico Severina
Published: April 2019

Food-waste is produced throughout all the food supply chain, with a large part already achieved at farm level. In fact, fruits and vegetables, which do not satisfy aesthetic demands, cannot be marketed, but their recovery could favour their valorisation for the obtainment of highly qualified goods. In this context, faulty zucchini fruits (cultivar ‘Lungo Fiorentino’), intended for disposal, were rescued as effective, inexpensive and bio-sustainable source for cosmeceutical purposes. Zucchini fruits underwent extraction and fractionation to obtain ZLF-O and ZLF-A extracts, which were chemically characterized by UHPLC-HRMS. ZLF-A extract, rich in flavonols and flavones, scavenged massively DPPH• and ABTS•+, and was not cytotoxic at doses up to 200 μ g/mL. Thus, ZLF-A was incorporated into a base cream formula. Zucchini-based emulsion was deeply screened for its antiradical properties and cytotoxicity towards human keratinocytes and fibroblasts. ZLF-A-enriched cream, whose chemical stability was assessed over time and mimicking different storage conditions, was further tested on reconstructed epidermis disks (EpiskinTM). The recovery of valuable chemical substances from zucchini agro-food waste, complying with the principles of valorisation and sustainable development, can represent a new market force for local farmers. Data acquired were eager to convey a suitable reuse of nutraceuticals rich zucchini waste.
Manufacture of Networks from Large Diameter Single-Walled Carbon Nanotubes of Particular Electrical Character
Authors: Turek Edyta , Kumanek Bogumila , Boncel Slawomir , Janas Dawid
Published: April 2019

We have demonstrated that the aqueous two-phase extraction (ATPE) can differentiate between large diameter single-walled carbon nanotubes (CNTs) by electrical character. Introduction of “hydration modulators” to the ATPE machinery has enabled us to isolate metallic and semiconducting CNTs with ease. We have also shown that often there is a trade-off between the purity of the obtained fractions and the ability to separate both metallic and semiconducting CNTs at the same time. To isolate the separated CNTs from the matrices, we have proposed a method based on precipitation and hydrolysis, which can eliminate the need to use lengthy dialysis routines. In the final step, we prepared thin free-standing films from the sorted material and probed how electrical charge is transported through such macroscopic ensembles.
Poor Bifidobacterial Colonization Is Associated with Late Provision of Colostrum and Improved with Probiotic Supplementation in Low Birth Weight Infants
Authors: Tanaka Katsunori , Nakamura Yoshitaka , Terahara Masaki , Yanagi Takahide , Nakahara Sayuri , Furukawa Ouki , Tsutsui Hidemi , Inoue Ryo , Tsukahara Takamitsu , Koshida Shigeki
Published: April 2019

This study aimed to evaluate the association between bifidobacterial colonization in low birth weight infants and perinatal factors, including the timing of initial colostrum and the effect of probiotics on this colonization. In this non-randomized controlled trial, we enrolled 98 low-birth-weight infants from a neonatal intensive care unit (NICU) in Japan. Infants were divided into three groups: group N (no intervention), group H (received non-live bifidobacteria), and group L (received live bifidobacteria). The number of bifidobacteria in the infants’ stools at 1 month of age was measured using real-time polymerase chain reaction (PCR). We divided infants into “rich bifidobacteria” (≥104.8 cells/g feces) and “poor bifidobacteria” (<104.8 cells/g feces) subgroups. The ratio of “rich bifidobacteria” infants was 20/31, 34/36, and 30/30 in groups N, H, and L, respectively. In group N, the “rich bifidobacteria” group received first colostrum significantly earlier than the “poor bifidobacteria” group (1 day vs. 4 days, P < 0.05). Compared with the N group, both groups H and L had a significantly high proportion of “rich bifidobacteria” infants (P < 0.05). Bifidobacterial colonization was poor in premature infants at 1 month compared with term infants, and the level of colonization was associated with the timing of initial provision of colostrum. Providing probiotics to premature infants can improve bifidobacterial colonization.
A Selective Role of Dietary Anthocyanins and Flavan-3-ols in Reducing the Risk of Type 2 Diabetes Mellitus: A Review of Recent Evidence
Authors: Burton-Freeman Britt , Brzeziński Michał , Park Eunyoung , Sandhu Amandeep , Xiao Di , Edirisinghe Indika
Published: April 2019

Type 2 diabetes mellitus (T2DM) is the most common form of DM and its prevalence is increasing worldwide. Because it is a progressive disease, prevention, early detection and disease course modification are possible. Diet plays a critical role in reducing T2DM risk. Therapeutic dietary approaches routinely recommend diets high in plant foods (i.e., vegetables, fruits, whole-grains). In addition to essential micronutrients and fiber, plant-based diets contain a wide-variety of polyphenols, specifically flavonoid compounds. Evidence suggests that flavonoids may confer specific benefits for T2DM risk reduction through pathways influencing glucose absorption and insulin sensitivity and/or secretion. The present review assesses the relationship between dietary flavonoids and diabetes risk reduction reviewing current epidemiology and clinical research. Collectively, the research indicates that certain flavonoids, explicitly anthocyanins and flavan-3-ols and foods rich in these compounds, may have an important role in dietary algorithms aimed to address diabetes risk factors and the development of T2DM.
Diet Supplemented with Antioxidant and Anti-Inflammatory Probiotics Improves Sperm Quality after Only One Spermatogenic Cycle in Zebrafish Model
Authors: Valcarce David G. , Riesco Marta F. , Martínez-Vázquez Juan M. , Robles Vanesa
Published: April 2019

Infertility is a medical concern worldwide and could also have economic consequences in farmed animals. Developing an efficient diet supplement with immediate effects on sperm quality is a promising tool for human reproduction and for domesticated animal species. This study aims at elucidating the effect of a short-time probiotic supplementation consisting of a mixture of two probiotic bacteria with proven antioxidant and anti-inflammatory activities on zebrafish sperm quality and male behavior. For this purpose, three homogeneous groups of males in terms of motility (<60%) were established. The control group was fed with a normal standard diet. The other received supplements: One group (vehicle control) was fed with maltodextrin and the other received a probiotic preparation based on a mixture (1:1) of Lactobacillus rhamnosus CECT8361 and Bifidobacterium longum CECT7347. The feeding regime was 21 days corresponding with a single spermatogenesis in zebrafish. The preparation did not modify animal weight, positively affected the number of fluent males, increased sperm concentration, total motility, progressive motility, and fast spermatozoa subpopulations. Moreover, the animals fed with the supplement showed different behavior patterns compared to control groups. Our results suggest a diet-related modulation on the exploration activity indicating a lower stress-like conduct. The studied formulation described here should be considered as advantageous in male reproductive biotechnology.
A Slow-Digesting Carbohydrate Diet during Rat Pregnancy Protects Offspring from Non-Alcoholic Fatty Liver Disease Risk through the Modulation of the Carbohydrate-Response Element and Sterol Regulatory Element Binding Proteins
Authors: Salto Rafael , Manzano Manuel , Girón María Dolores , Cano Ainara , Castro Azucena , Vílchez José Dámaso , Cabrera Elena , López-Pedrosa José María
Published: April 2019

High-fat (HF) and rapid digestive (RD) carbohydrate diets during pregnancy promote excessive adipogenesis in offspring. This effect can be corrected by diets with similar glycemic loads, but low rates of carbohydrate digestion. However, the effects of these diets on metabolic programming in the livers of offspring, and the liver metabolism contributions to adipogenesis, remain to be addressed. In this study, pregnant insulin-resistant rats were fed high-fat diets with similar glycemic loads but different rates of carbohydrate digestion, High Fat-Rapid Digestive (HF–RD) diet or High Fat-Slow Digestive (HF–SD) diet. Offspring were fed a standard diet for 10 weeks, and the impact of these diets on the metabolic and signaling pathways involved in liver fat synthesis and storage of offspring were analyzed, including liver lipidomics, glycogen and carbohydrate and lipid metabolism key enzymes and signaling pathways. Livers from animals whose mothers were fed an HF–RD diet showed higher saturated triacylglycerol deposits with lower carbon numbers and double bond contents compared with the HF–SD group. Moreover, the HF–RD group exhibited enhanced glucose transporter 2, pyruvate kinase (PK), acetyl coenzyme A carboxylase (ACC) and fatty acid (FA) synthase expression, and a decrease in pyruvate carboxylase (PyC) expression leading to an altered liver lipid profile. These parameters were normalized in the HF–SD group. The changes in lipogenic enzyme expression were parallel to changes in AktPKB phosphorylation status and nuclear expression in carbohydrate-response element and sterol regulatory element binding proteins. In conclusion, an HF–RD diet during pregnancy translates to changes in liver signaling and metabolic pathways in offspring, enhancing liver lipid storage and synthesis, and therefore non-alcoholic fatty liver disease (NAFLD) risk. These changes can be corrected by feeding an HF–SD diet during pregnancy.
Synergistic Effects of DHA and Sucrose on Body Weight Gain in PUFA-Deficient Elovl2 -/- Mice
Authors: Pauter Anna M. , Fischer Alexander W. , Bengtsson Tore , Asadi Abolfazl , Talamonti Emanuela , Jacobsson Anders
Published: April 2019

The omega-3 polyunsaturated fatty acid docosahexaenoic acid (DHA) is implicated in the regulation of both lipid and carbohydrate metabolism. Thus, we questioned whether dietary DHA and low or high content of sucrose impact on metabolism in mice deficient for elongation of very long-chain fatty acids 2 (ELOVL2), an enzyme involved in the endogenous DHA synthesis. We found that Elovl2 -/- mice fed a high-sucrose DHA-enriched diet followed by the high sucrose, high fat challenge significantly increased body weight. This diet affected the triglyceride rich lipoprotein fraction of plasma lipoproteins and changed the expression of several genes involved in lipid metabolism in a white adipose tissue. Our findings suggest that lipogenesis in mammals is synergistically influenced by DHA dietary and sucrose content.
The Nature and Quality of Australian Supermarkets’ Policies That Can Impact Public Health Nutrition, and Evidence of Their Practical Application: A Cross-Sectional Study
Authors: Pulker Claire Elizabeth , Trapp Georgina S. A. , Scott Jane Anne , Pollard Christina Mary
Published: April 2019

Improving population diets is a public health priority, and calls have been made for corporations such as supermarkets to contribute. Supermarkets hold a powerful position within the food system, and one source of power is supermarket own brand foods (SOBFs). Many of the world’s largest supermarkets have corporate social responsibility (CSR) policies that can impact public health, but little is known about their quality or practical application. This study examines the nature and quality of Australian supermarkets’ CSR policies that can impact public health nutrition, and provides evidence of practical applications for SOBFs. A content analysis of CSR policies was conducted. Evidence of supermarkets putting CSR policies into practice was derived from observational audits of 3940 SOBFs in three large exemplar supermarkets (Coles, Woolworths, IGA) in Perth, Western Australia (WA). All supermarkets had some CSR policies that could impact public health nutrition; however, over half related to sustainability, and many lacked specificity. All supermarkets sold some nutritious SOBFs, using marketing techniques that made them visible. Findings suggest Australian supermarket CSR policies are not likely to adequately contribute to improving population diets or sustainability of food systems. Setting robust and meaningful targets, and improving transparency and specificity of CSR policies, would improve the nature and quality of supermarket CSR policies and increase the likelihood of a public health benefit.
Determinants of Adherence to Healthy Eating Patterns in a Population of Children and Adolescents: Evidence on the Mediterranean Diet in the City of Mataró (Catalonia, Spain)
Authors: Arcila-Agudelo Ana Maria , Ferrer-Svoboda Carmen , Torres-Fernàndez Teresa , Farran-Codina Andreu
Published: April 2019

Despite its benefits, the Mediterranean diet (MD) is being abandoned or not adopted by young generations in most Mediterranean countries. In Spain, up to 69% of the child and adolescent population has been found to have suboptimal adherence to the MD. The aim of this study was to analyze which factors are associated with an optimal adherence to the MD in school-age children and adolescents from Mataró, Spain. A cross-sectional study was performed on 1177 children and adolescents aged between 6 and 18 years from Mataró. The Mediterranean Diet Quality Index for Children and Adolescents (KIDMED index) was used to evaluate adherence to a MD. We found that over 59% of subjects showed suboptimal adherence to a MD, with this prevalence being higher for secondary school than for primary school children. The factors positively associated with following an optimal MD were the mother’s education level, children at the primary school level, the absence of distractions at breakfast, and regular physical activity. The availability of spending money was negatively associated with the likelihood of optimal adherence to a MD. Future research should study more in-depth the possible causality between the factors studied and adherence to a MD.
In Vivo Biocompatibility of Electrospun Biodegradable Dual Carrier (Antibiotic + Growth Factor) in a Mouse Model—Implications for Rapid Wound Healing
Authors: Dwivedi Charu , Pandey Himanshu , Pandey Avinash C. , Patil Sandip , Ramteke Pramod W. , Laux Peter , Luch Andreas , Singh Ajay Vikram
Published: April 2019

Tissue engineering technologies involving growth factors have produced one of the most advanced generations of diabetic wound healing solutions. Using this approach, a nanocomposite carrier was designed using Poly(d,l-lactide-co-glycolide) (PLGA)/Gelatin polymer solutions for the simultaneous release of recombinant human epidermal growth factor (rhEGF) and gentamicin sulfate at the wound site to hasten the process of diabetic wound healing and inactivation of bacterial growth. The physicochemical characterization of the fabricated scaffolds was carried out using scanning electron microscopy (SEM) and X-ay diffraction (XRD). The scaffolds were analyzed for thermal stability using thermogravimetric analysis and differential scanning calorimetry. The porosity, biodegradability, and swelling behavior of the scaffolds was also evaluated. Encapsulation efficiency, drug loading capacity, and in vitro drug release were also investigated. Further, the bacterial inhibition percentage and detailed in vivo biocompatibility for wound healing efficiency was performed on diabetic C57BL6 mice with dorsal wounds. The scaffolds exhibited excellent wound healing and continuous proliferation of cells for 12 days. These results support the applicability of such systems in rapid healing of diabetic wounds and ulcers.
Synthesis and Electrospinning of Polycaprolactone from an Aluminium-Based Catalyst: Influence of the Ancillary Ligand and Initiators on Catalytic Efficiency and Fibre Structure
Authors: Kouparitsas Ioannis K. , Mele Elisa , Ronca Sara
Published: April 2019

In the present study, we investigated the catalytic performance of a 2,2′-methylenebis(6-tert-butyl-4-methylphenol) (MDBP)–aluminium complex for the ring-opening polymerisation (ROP) of ε-caprolactone in combination with various alcohols as initiators. Three different alcohols were investigated: 1-adamantanemethanol (A), 1H,1H,2H,2H-perfluoro-1-octanol (F) and isopropanol (I). Samplings of polycaprolactone (PCL) at various reaction times showed a linear increase in the polymer molecular weight with time, with very narrow polydispersity, confirming the living nature of the catalytic system. Scanning electron microscope (SEM) images of electrospun PCL fibre mats produced from 30 wt % dichloromethane/dimethyl sulfoxide solutions showed a high level of surface porosity with a reasonable homogeneity of fibre diameters. The values of the liquid absorption and water contact angle were measured for the electrospun mats, with the F-capped PCL consistently showing absorption values up to three times higher than those of PCL samples capped with the other two alcohols, as well as increased hydrophobicity. The nature of the alcohol can influence the surface hydrophobicity and absorption ability of electrospun fibres, demonstrating the possibility of tailoring material properties through controlled polymerisation.
One-Pot Synthesis of Amide-Functional Main-Chain Polybenzoxazine Precursors
Authors: Durukan Canan , Kiskan Baris , Yagci Yusuf
Published: April 2019

Main-chain polybenzoxazines containing amide linkages were successfully prepared in one pot. Three different polymers were synthesized by reacting 3,4-dihydrocoumarine (DHC) and paraformaldehyde with 1,3-diaminopropane or 1,6-diaminohexane or Jeffamine ED-900. The one-pot reaction proceeded through the combination of the ring-opening of DHC with amines, and subsequent Mannich and ring-closure reactions occurring in a cascading manner. The obtained polymer from Jeffamine exhibited good film-forming properties, and free-standing flexible films were easily solvent- casted on Teflon plates. All polymeric precursors were characterized by spectroscopic analysis, and their curing behavior and thermal stability were investigated by differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA).
Some Important Issues of the Commercial Production of 1-D Nano-PANI
Authors: Wu Ying , Wang Jixiao , Ou Bin , Zhao Song , Wang Zhi
Published: April 2019

One-dimensional polyaniline nano-materials (1-D nano-PANI) have great promise applications in supercapacitors, sensors and actuators, electrochromic devices, anticorrosive coatings, and other nanometer devices. Consequently, commercial production of 1-D nano-PANI at large-scale needs to be quickly developed to ensure widespread usage of this material. Until now, approaches—including hard template methods, soft template methods, interfacial polymerization, rapid mixing polymerization, dilute polymerization, and electrochemical polymerization—have been reported to be used to preparation of this material. Herein, some important issues dealing with commercial production of 1-D nano-PANI are proposed based on the complexity of the synthetic process, its characters, and the aspects of waste production and treatment in particular. In addition, potential solutions to these important issues are also proposed.
Evaluating Phthalate Contaminant Migration Using Thermal Desorption–Gas Chromatography–Mass Spectrometry (TD–GC–MS)
Authors: Ouchi Yukihiro , Yanagisawa Hiroyuki , Fujimaki Shigehiko
Published: April 2019

This study describes a methodology for evaluating regulatory levels of phthalate contamination. By collecting experimental data on short-term phthalate migration using thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS), the migration of di(2-ethylhexyl) phthalate (DEHP) from polyvinyl chloride (PVC) to polyethylene (PE) was found to be expressed by the Fickian approximation model, which was originally proposed for solid (PVC)/liquid (solvent) migration of phthalates. Consequently, good data correlation was obtained using the Fickian approximation model with a diffusion coefficient of 4.2 × 10−12 cm2/s for solid (PVC)/ solid (PE) migration of DEHP at 25 °C. Results showed that temporary contact with plasticized polymers under a normal, foreseeable condition may not pose an immediate risk of being contaminated by phthalates at regulatory levels. However, as phthalates are small organic molecules designed to be dispersed in a variety of polymers as plasticizers at a high compounding ratio, the risk of migration-related contamination can be high in comparison with other additives, especially under high temperatures. With these considerations in mind, the methodology for examining regulatory levels of phthalate contamination using TD–GC–MS has been successfully demonstrated from the viewpoint of its applicability to solid (PVC)/solid (PE) migration of phthalates.
Enhancement of Hydrotropic Fractionation of Poplar Wood Using Autohydrolysis and Disk Refining Pretreatment: Morphology and Overall Chemical Characterization
Authors: Gu Yanting , Bian Huiyang , Wei Liqing , Wang Ruibin
Published: April 2019

Solid acids have been proposed as a hydrolytic agent for wood biomass dissolution. In this work, we presented an environmentally friendly physicochemical treatment to leave behind cellulose, dissolve hemicellulose, and remove lignin from poplar wood. Several pretreatments, such as autohydrolysis and disk refining, were compared to optimize and modify the process. The p-toluenesulfonic acid could extract lignin from wood with a small amount of cellulose degradation. Disk refining with subsequent acid hydrolysis (so-called physicochemical treatment) doubled the delignification efficiency. A comprehensive morphology and overall chemical composition were provided. The crystallinity index (CrI) of treated poplar was increased and the chemical structure was changed after physicochemical treatment. Optical microscopy and scanning electron microscopy analysis demonstrated physicochemical treatment affected the morphology of poplar wood by removing lignin and generating fiberization. In general, this work demonstrated this physicochemical method could be a promising fractionation technology for lignocellulosic biomass due to its advantages, such as good selectivity, in removing lignin while preserving cellulose.
Impact of Soil Reflectance Variation Correction on Woody Cover Estimation in Kruger National Park Using MODIS Data
Authors: Ibrahim Sa’ad , Balzter Heiko , Tansey Kevin , Mathieu Renaud , Tsutsumida Narumasa
Published: April 2019

Time-series of imagery acquired by the Moderate Resolution Imaging Spectroradiometer (MODIS) has previously been used to estimate woody and herbaceous vegetation cover in savannas. However, this is challenging due to the mixture of woody and herbaceous plant functional types with specific contributions to the phenological signal and variations in soil background reflectance signatures observed from satellite. These factors cause variations in the accuracy and precision of woody cover estimates from different modelling approaches and datasets. Here, woody cover is estimated over Kruger National Park (KNP) from the MODIS 16-day composite time-series data using dry season NDVI/SAVI images and applying NDVIsoil determination methods. The woody cover estimates when NDVIsoil was ignored had R2 = 0.40, p < 0.01, slope = 1.01, RMSE (root mean square error) = 15.26% and R2 = 0.32, p < 0.03, slope = 0.79, RMSE = 16.39% for NDVIpixel and SAVIpixel, respectively, when compared to field plot data of plant functional type fractional cover. The woody cover estimated from the soil determination methods had a slope closer to 1 for both NDVI and SAVI but also a slightly higher RMSE. For a soil-invariant method, RMSE = 19.04% and RMSE = 17.34% were observed for NDVI and SAVI respectively, while for a soil-variant method, RMSE = 18.28% and RMSE = 19.17% were found for NDVI and SAVI. The woody cover estimated from all models had a high correlation and significant relationship with LiDAR/SAR based estimates and a woody cover map produced by Bucini. Woody cover maps are required for vegetation succession monitoring, grazing impact assessment, climate change mitigation and adaptation research and dynamic vegetation model validation.
Evaluation of the Potential of Convolutional Neural Networks and Random Forests for Multi-Class Segmentation of Sentinel-2 Imagery
Authors: Syrris Vasileios , Hasenohr Paul , Delipetrev Blagoj , Kotsev Alexander , Kempeneers Pieter , Soille Pierre
Published: April 2019

Motivated by the increasing availability of open and free Earth observation data through the Copernicus Sentinel missions, this study investigates the capacity of advanced computational models to automatically generate thematic layers, which in turn contribute to and facilitate the creation of land cover products. In concrete terms, we assess the practical and computational aspects of multi-class Sentinel-2 image segmentation based on a convolutional neural network and random forest approaches. The annotated learning set derives from data that is made available as result of the implementation of European Union’s INSPIRE Directive. Since this network of data sets remains incomplete in regard to some geographic areas, another objective of this work was to provide consistent and reproducible ways for machine-driven mapping of these gaps and a potential update of the existing ones. Finally, the performance analysis identifies the most important hyper-parameters, and provides hints on the models’ deployment and their transferability.
GIS-based Landform Classification of Eneolithic Archaeological Sites in the Plateau-plain Transition Zone (NE Romania): Habitation Practices vs. Flood Hazard Perception
Authors: Mihu-Pintilie Alin , Nicu Ionut Cristi
Published: April 2019

The landforms of the Earth’s surface ranging from large-scale features to local topography are factors that influence human behavior in terms of habitation practices. The ability to extract geomorphological settings using geoinformatic techniques is an important aspect of any environmental analysis and archaeological landscape approach. Morphological data derived from DEMs with high accuracies (e.g., LiDAR data), can provide valuable information related to landscape modelling and landform classification processes. This study applies the first landform classification and flood hazard vulnerability of 730 Eneolithic (ca. 5000–3500 BCE) settlement locations within the plateau-plain transition zone of NE Romania. The classification was done using the SD (standard deviation) of TPI (Topographic Position Index) for the mean elevation (DEV) around each archaeological site, and HEC-RAS flood hazard pattern generated for 0.1% (1000 year) discharge insurance. The results indicate that prehistoric communities preferred to place their settlements for defensive purposes on hilltops, or in the close proximity of a steep slope. Based on flood hazard pattern, 8.2% out of the total sites had been placed in highly vulnerable areas. The results indicate an eco-cultural niche connected with habitation practices and flood hazard perception during the Eneolithic period in the plateau-plain transition zone of NE Romania and contribute to archaeological predictive modelling.
A Possible Synergy between Culture and Religion for the Sustainability of Tourism of Pompeii
Authors: Cortese Flora , D’Ambrosio Ida , Petracca Miriam
Published: April 2019

Tourism scholars and players of the sector alike are very interested in the motivations for the tourist’s journey, as they influence the demand—with regard to the choice of the destination and the organization of the trip—and the offer—with regard to the definition of the tourism product. Religious tourism is an important area of the scientific debate on the motivation to travel; part of the literature clearly distinguishes the cultural and laical motivation of tourists (which can be considered religious tourism) from the desire to live an experience of faith (pilgrimage), while today, the orientation of scholars is to bring back under the label “religious” spiritual, religious, and cultural motivations. This study analyzes the case of the city of Pompeii, and it aims to investigate the possible synergy that could be created between the historical-cultural and religious interests of the city, identifying possible strategies for sustainable tourism. The study develops a quali-quantitative analysis of the reviews of the “Pontifical Sanctuary of the Blessed Virgin Mary of the Holy Rosary of Pompeii” on TripAdvisor and presents a content analysis on the most frequent words utilized by users to describe their touristic experience.
Demand Uncertainty, Cost Behavior, and the Asian Financial Crisis: Evidence from Korea
Authors: Kwon Dae-Hyun
Published: April 2019

The mix of fixed and variable costs in response to environmental changes is important for the sustainability of a firm. This study examines how demand uncertainty affects managers’ cost structure decisions. Using data on Korean firms from 1982 to 2015, my study provides evidence that cost rigidity increases in demand uncertainty. This finding implies that managers under higher uncertainty will increase the committed capacity to reduce congestion costs, resulting in a more rigid (less elastic) cost structure with higher fixed and lower variable costs in the short term. I also investigate the effect of the 1997 Asian financial crisis on cost rigidity. I predict that the massive structural changes entailed by the crisis, such as the deteriorated access to external funds, increase in the tendency of loss aversion, and expansion of outsourcing and temporary job positions, will reduce the magnitude of cost rigidity following greater demand uncertainty. Consistent with the prediction, the positive relation between demand uncertainty and cost rigidity becomes weaker in the period following the crisis, compared to the pre-crisis period.
Exploring the Effects of Government Policies on Economic Performance: Evidence Using Panel Data for Korean Renewable Energy Technology Firms
Authors: Sung Bongsuk , Choi Myoung Shik , Song Woo-Yong
Published: April 2019

Previous studies have investigated how government policies on renewable energy technology (RET) affect economic performance at the industrial level. However, each firm in the RET industry is heterogeneous in terms of their capacities, resources, and the amount of public subsidies they receive. Considering the context in which public subsidies are provided to firms, this study econometrically investigates the effects of government policies on firms’ financial performance using panel data from the Korean RET industry. We consider the results of various panel framework tests; establish a panel vector autoregressive model in first differences; and test the dynamic relationships between firms’ financial performance, government subsidies (R&D- and non-R&D-related), firm size and age, and organizational slack, using a bias-corrected least squares dummy variable estimator. We find that R&D- and non-R&D-related subsidies positively affect firms’ financial performance in the long run. In the short run, there are bidirectional positive causal relationships between firms’ financial performance and organizational slack (and non-R&D-related subsidy), and firm size and non-R&D-related subsidy. A positive short-run relationship runs from R&D-related subsidy to firms’ financial performance, from firm age to non-R&D-related subsidy, and from firm size to firm age. Further, there are dynamic effects in all estimations, demonstrating that the dependent variables of the previous period enhance their values in the current period. The results provide some policy and strategic implications.
Agent-Based Modeling of Sustainable Ecological Consumption for Grasslands: A Case Study of Inner Mongolia, China
Authors: Yan Huimin , Pan Lihu , Xue Zhichao , Zhen Lin , Bai Xuehong , Hu Yunfeng , Huang He-Qing
Published: April 2019

Sustainable ecosystem services consumption is of vital importance to the survival and development of human society. How to balance the conflicts between ecosystem protection and ecosystem services consumption by local residents has been a serious challenge, especially in ecologically vulnerable areas. To explore the reasonable ecosystem services consumption approaches of grassland ecosystems for sustainable land system management, this study takes Hulun Buir of the Inner Mongolia Autonomous Region as a case study region and develops an EcoC-G (ecological consumption of grassland) model based on herders’ livelihood behaviors using the agent-based model technique to simulate the dynamics of ecosystem pressure, livestock production, and living quality of herders under different grassland management scenarios over the next 30 years. The EcoC-G model links the supply and consumption of grassland ecosystem services by calculating the ecosystem net primary productivity (NPP) supply and household NPP consumption. The model includes three sub-models, namely, the individual status transferring sub-model, the households’ grassland-use decision sub-model, and the ecosystem pressure sub-model. In accordance with multi-objective grassland management practices, the following four land management scenarios were simulated: (1) baseline scenario, (2) increasing household’s living standard, (3) ecosystem protection, and (4) balancing living standard improvement with the protection of the ecosystem. The result indicates that by focusing on the NPP supply and consumption of the grassland ecosystem, the EcoC-G is capable of simulating the impacts of herders’ livelihood behaviors on grassland ecosystems. If timely grassland management strategies are implemented, it is possible to relieve the ecosystem pressure and improve the livelihood of local herders. The specific scenario simulation results are: (1) Under the current grassland management mode, the pasture could never be overgrazed, and herders could achieve the basic living standard, but the accumulated wealth decreased due to the decline of livestock. (2) With grazing control, herders can accumulate wealth by increasing the breeding amount and reducing the marketing rate, but the ecosystem consumption pressure can reach a maximum of 2.3 times. (3) With strict restrictions on the livestock number, the pressure on the ecosystem decreases; however, herders might not achieve basic living standards. (4) Modest regulation leads to rational ecological consumption intervals, meaning the ecosystem pressure will become stable and herders can gradually accumulate wealth with the achievement of basic living standards in advance.
Advanced IT-Based Future Sustainable Computing (2017–2018)
Authors: Park Jong Hyuk
Published: April 2019

Future Sustainability Computing (FSC) is an emerging concept that holds various types of paradigms, rules, procedures, and policies to support breadth and length of the deployment of Information Technology (IT) for abundant life. However, advanced IT-based FCS is facing several sustainability problems in different information processing and computing environments. Solutions to these problems can call upon various computational and algorithmic frameworks that employ optimization, integration, generation, and utilization technique within cloud, mobile, and cluster computing, such as meta-heuristics, decision support systems, prediction and control, dynamical systems, machine learning, and so on. Therefore, this special issue deals with various software and hardware design, novel architectures and frameworks, specific mathematical models, and efficient modeling-simulation for advance IT-based FCS. We accepted eighteen articles in the six different IT dimensions: machine learning, blockchain, optimized resource provision, communication network, IT governance, and information security. All accepted articles contribute to the applications and research in the FCS, such as software and information processing, cloud storage organization, smart devices, efficient algorithmic information processing and distribution.
On Ω Class of Mappings in a p-Cyclic Complete Metric Space
Authors: Karapınar Erdal , Karpagam Saravanan , Magadevan Prabavathy , Zlatanov Boyan
Published: April 2019

In this manuscript, we introduce the concept of Ω -class of self mappings on a metric space and a notion of p-cyclic complete metric space for a natural number ( p ≥ 2 ) . We not only give sufficient conditions for the existence of best proximity points for the Ω -class self-mappings that are defined on p-cyclic complete metric space, but also discuss the convergence of best proximity points for those mappings.
A Note on the Truncated-Exponential Based Apostol-Type Polynomials
Authors: Srivastava H. M. , Araci Serkan , Khan Waseem A. , Acikgöz Mehmet
Published: April 2019

In this paper, we propose to investigate the truncated-exponential-based Apostol-type polynomials and derive their various properties. In particular, we establish the operational correspondence between this new family of polynomials and the familiar Apostol-type polynomials. We also obtain some implicit summation formulas and symmetric identities by using their generating functions. The results, which we have derived here, provide generalizations of the corresponding known formulas including identities involving generalized Hermite-Bernoulli polynomials.
Neutrosophic Optimization Model and Computational Algorithm for Optimal Shale Gas Water Management under Uncertainty
Authors: Ahmad Firoz , Adhami Ahmad Yusuf , Smarandache Florentin
Published: April 2019

Shale gas energy is the most prominent and dominating source of power across the globe. The processes for the extraction of shale gas from shale rocks are very complex. In this study, a multiobjective optimization framework is presented for an overall water management system that includes the allocation of freshwater for hydraulic fracturing and optimal management of the resulting wastewater with different techniques. The generated wastewater from the shale fracking process contains highly toxic chemicals. The optimal control of a massive amount of contaminated water is quite a challenging task. Therefore, an on-site treatment plant, underground disposal facility, and treatment plant with expansion capacity were designed to overcome environmental issues. A multiobjective trade-off between socio-economic and environmental concerns was established under a set of conflicting constraints. A solution method—the neutrosophic goal programming approach—is suggested, inspired by independent, neutral/indeterminacy thoughts of the decision-maker(s). A theoretical computational study is presented to show the validity and applicability of the proposed multiobjective shale gas water management optimization model and solution procedure. The obtained results and conclusions, along with the significant contributions, are discussed in the context of shale gas supply chain planning policies over different time horizons.
Development and Validation of a Liquid Chromatography High-Resolution Mass Spectrometry Method for the Simultaneous Determination of Mycotoxins and Phytoestrogens in Plant-Based Fish Feed and Exposed Fish
Authors: Johny Amritha , Fæste Christiane Kruse , Bogevik André S. , Berge Gerd Marit , Fernandes Jorge M.O. , Ivanova Lada
Published: April 2019

New protein sources in fish feed require the assessment of the carry-over potential of contaminants and anti-nutrients from feed ingredients into the fish, and the assessment of possible health risks for consumers. Presently, plant materials including wheat and legumes make up the largest part of aquafeeds, so evaluation of the transfer capabilities of typical toxic metabolites from plant-infesting fungi and of vegetable phytoestrogens into fish products is of great importance. With the aim of facilitating surveillance of relevant mycotoxins and isoflavones, we have developed and validated a multi-analyte LC-HRMS/MS method that can be used to ensure compliance to set maximum levels in feed and fish. The method performance characteristics were determined, showing high specificity for all 25 targeted analytes, which included 19 mycotoxins and three isoflavones and their corresponding aglycons with sufficient to excellent sensitivities and uniform analytical linearity in different matrices. Depending on the availability of matching stable isotope-labelled derivates or similar-structure homologues, calibration curves were generated either by using internal standards or by matrix-matched external standards. Precision and recovery data were in the accepted range, although they varied between the different analytes. This new method was considered as fit-for-purpose and applied for the analysis of customised fish feed containing wheat gluten, soy, or pea protein concentrate as well as salmon and zebrafish fed on diets with these ingredients for a period of up to eight weeks. Only mycotoxin enniatin B, at a level near the limit of detection, and low levels of isoflavones were detected in the feed, demonstrating the effectiveness of maximum level recommendations and modern feed processing technologies in the Norwegian aquaculture industry. Consequently, carry-over into fish muscle was not observed, confirming that fillets from plant-fed salmon were safe for human consumption.
Production of Cyanotoxins by Microcystis aeruginosa Mediates Interactions with the Mixotrophic Flagellate Cryptomonas
Authors: Princiotta Sarah DeVaul , Hendricks Susan P. , White David S.
Published: April 2019

Eutrophication of inland waters is expected to increase the frequency and severity of harmful algal blooms (HABs). Toxin-production associated with HABs has negative effects on human health and aquatic ecosystem functioning. Despite evidence that flagellates can ingest toxin-producing cyanobacteria, interactions between members of the microbial loop are underestimated in our understanding of the food web and algal bloom dynamics. Physical and allelopathic interactions between a mixotrophic flagellate (Cryptomonas sp.) and two strains of a cyanobacteria (Microcystis aeruginosa) were investigated in a full-factorial experiment in culture. The maximum population growth rate of the mixotroph (0.25 day−1) occurred during incubation with filtrate from toxic M. aeruginosa. Cryptomonas was able to ingest toxic and non-toxic M. aeruginosa at maximal rates of 0.5 and 0.3 cells day−1, respectively. The results establish that although Cryptomonas does not derive benefits from co-incubation with M. aeruginosa, it may obtain nutritional supplement from filtrate. We also provide evidence of a reduction in cyanotoxin concentration (microcystin-LR) when toxic M. aeruginosa is incubated with the mixotroph. Our work has implications for “trophic upgrading” within the microbial food web, where cyanobacterivory by nanoflagellates may improve food quality for higher trophic levels and detoxify secondary compounds.