bluuebunny/crossref_metadata_2025 huggingface dataset:
ПЕРСПЕКТИВЫ ЭКОНОМИЧЕСКОЙ ИНТЕГРАЦИИ АБХАЗИИ И РОССИИ
Authors: Сипаро Константин
Published: September 2021

Цель работы: целями данной статьи являются исследование экономики Абхазии после признания независимости, обзор формирования экономических отношений с Россией в условиях новых реалий, изучение имеющихся экономических тенденций. Метод или методология проведения работы: проводится сравнение экономики до и после признания независимости, анализируются торговые отношения, структура импорта и экспорта за последние годы. Выявляются существующие закономерности в развитии, перспективы развития и сотрудничества в разных сферах, а также озвучиваются существующие проблемы. Область применения результатов: результаты исследования важны для понимания дальнейших перспектив сотрудничества между Россией и Абхазией на государственном уровне, а также полезны для бизнеса и инвесторов. Выводы. На основании всего вышеизложенного сделаны выводы, отражающие позицию автора и его понимание текущей ситуации. Названы ключевые проблемы, определены возможные варианты их решения, а также обозначены перспективы дальнейшего развития.
Study of the residual imperfections using methods of probability theory
Authors: Kuzmin D. A.
Published: September 2021

Discontinuities in the products that occur during manufacture, mounting or upon operation can be missed during non-destructive testing which do not provide their complete detectability at a current level of the technology. Therefore, it is necessary to take into account that certain structural elements may have discontinuities of significant dimensions. We present the results of using the methods of probability theory in studying the residual imperfections that remains in the structure after non-destructive control and repair of the previously identified defects. We used the results of operational control of units carried out by ultrasonic and radiographic methods. We present a method for determining a multifactorial coefficient that takes into account the detectability of defects, the number of control procedures and the errors in the instrumentation and methodological support, as well as a generalized equation for the probability distribution of detecting discontinuities. The developed approach provides assessing of the level of damage to the studied objects, their classification proceeding from the quantitative data and determination of the values of postulated discontinuities for deterministic calculations. The results obtained can be used to improve the methods of monitoring NPP facilities.
mRNA vaccine effectiveness against COVID-19-related hospitalisations and deaths in older adults: a cohort study based on data linkage of national health registries in Portugal, February to August 2021
Authors: Nunes Baltazar , Rodrigues Ana Paula , Kislaya Irina , Cruz Camila , Peralta-Santos André , Lima João , Pinto Leite Pedro , Sequeira Duarte , Matias Dias Carlos , Machado Ausenda
Published: September 2021

Through deterministic data linkage of health registries, mRNA vaccine effectiveness (VE) against COVID-19-related hospitalisations and deaths was measured in 1,880,351 older adults. VE against hospitalisations was 94% (95% confidence interval (CI): 88–97) and 82% (95% CI: 72–89) for those 65–79 and ≥ 80 years old, with no evidence of waning 98 days after dose two. VE against mortality was 96% (95% CI: 92–98) and 81% (95% CI: 74–87) in these two age groups.
Portfolio Asset Allocation Decisions: A Meta-Analysis
Authors: Gusni Gusni , Nugraha Nugraha
Published: September 2021

Portfolio asset allocation decisions are not passive as mention in the modern portfolio theory, because many factors that can influence it. The purpose of this study is to explain the portfolio asset allocation decisions based on the results of previous research studies by using a meta-analysis approach. The meta-analysis was carried out from a systematic review of the literature review. This study uses secondary data gathered from the various reputable journal by using 14 relevance research that has been published for the period of 2005 – 2019. The result explains that various empirical evidence of many studies on portfolio asset allocation decisions systematically can provide an overview of research trends and types of research conducted by researchers. Most of the studies are quantitative research, use a more behavioral approach, and provide new insights related to factors that can influence investors in making portfolio asset allocation decisions
Breast-conserving treatment in oncoplastic times: indications, cosmesis, and quality of life
Authors: Oliveira-Junior Idam de , Haikel Raphael Luiz , Vieira René Aloísio da Costa
Published: September 2021

Breast-conserving treatment was established as an oncologically safe procedure for breast cancer. However, the cosmetic outcomes of breast-conserving treatments are often unsatisfactory. In this scenario, oncoplastic breast-conserving surgery incorporated plastic surgery concepts and techniques into the oncological treatment in order to ensure better cosmesis, thus increasing the indications for breast-conserving treatment. At the same time, oncoplastic breast-conserving surgery is usually presented as a generic term, which should be evaluated taking many aspects into account: indication, patient selection, the surgery itself, cosmetic quality, and quality of life — data that are still scarce in the literature.
ANALISIS KELAYAKAN USAHATANI SAYURAN HIDROPONIK DI KOTA MATARAM
Authors: Putri Ria Septiana Sasmita , Anwar Anwar , Yakin Addinul
Published: September 2021

Tujuan penelitian untuk menganalisis: (1) besar pendapatan petani berdasarkan analisis struktur biaya, produksi dan penerimaan di Kota Mataram, (2) kelayakan usahatani sayuran hidroponik di Kota Mataram dan (3) kendala-kendala yang dihadapi oleh petani sayuran hidroponik di Kota Mataram.

 

Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan unit analisis petani sayuran hidroponik di Kota Mataram. Lokasi penelitian ditetapkan secara “purposive sampling” atas pertimbangan bahwa kecamatan yang terpilih terdapat petani yang sudah memproduksi sayuran hidroponik dengan skala komersial. Jumlah responden ditetapkan secara “sensus” sebanyak 4 orang. Analisis yang digunakan adalah: analisis pendapatan, analisis break event point, analisis revenue cost ratio, analisis revenue on investment.

 

Kesimpulan dari penelitian ini yaitu; (1) Sayuran hidroponik di Kota Mataram yang diproduksi diantaranya basil 36,75 kg dengan pendapatan yang diperoleh sebesar Rp 511.848; selada keriting 37,25 kg dengan pendapatan yang diperoleh sebesar Rp 268.964; selada merah 86 kg dengan pendapatan sebesar Rp 2.143.914; pakcoy 150 kg dengan pendapatan sebesar Rp 256.297. (2) Kelayakan usahatani sayuran hidroponik di Kota Mataram berdasarkan BEP pada sayuran basil diperoleh BEP harga Rp 22.322/kg, BEP produksi 23 kg, nilai R/C 1,53, ROI 53,18 %; selada keriting dengan BEP harga Rp 19.030/kg, BEP produksi 27 kg, R/C 1,33 dan ROI 32,86 %; selada merah diperoleh BEP harga Rp 10.071/kg, BEP produksi 25 kg, R/C 3,48, ROI 247,54 %, pakcoy dengan nilai BEP harga Rp 8.291, BEP produksi 124 kg, R/C 1,21 dan ROI 20,61 %. Nilai BEP lebih kecil dari nilai rata-rata yang berlaku, nilai R/C > 1, nilai ROI > 3,00%. Artinya  bahwa usahatani sayuran hidroponik di Kota Mataram layak untuk diusahakan. (3) Kendala yang dihadapi dalam usahatani sayuran hidroponik ini terbagi menjadi 2 kriteria yaitu secara teknis (instalasi irigasi, hama dan penyakit) dan non teknis (pestisida, pengetahuan, pemasaran dan fluktuasi harga).
EVALUASI PELAKSANAAN PROGRAM KAWASAN RUMAH PANGAN LESTARI DI KECAMATAN GANGGA KABUPATEN LOMBOK UTARA
Authors: Hidayati Erni , Sjah Taslim , Tanaya I Gusti Lanang Parta
Published: September 2021

Tujuan penelitian ini adalah untuk mengevaluasi pelaksanaan program kawasan rumah pangan lestari di Kecamatan Gangga Kabupaten Lombok Utara dan menganalisis kendala-kendala yang dihadapi oleh pelaku usaha pekarangan. Metode yang digunakan dalam penelitian ini adalah metode deskriptif. Penentuan daerah penelitian ini ditentukan secara purposive sampling karena desa tersebut merupakan desa yang pertama kali menerapkan KRPL dengan memilih Kecamatan Gangga. Penentuan jumlah responden dilakukan secara quota sampling dengan menetapkan 30 responden dari pelaku usaha. Pelaku usaha pekarangan dipilih secara accidental sampling. Hasil penelitian menunjukkan bahwa pelaksanaan program KRPL di Kecamatan Gangga Kabupaten Lombok Utara dinilai berhasil, dan perlu diprogramkan di lokasi-lokasi lain.
ANALISIS NILAI TAMBAH DAN PENYERAPAN TENAGA KERJA PADA AGROINDUSTRI ABON BERBASIS IKAN DI KOTA MATARAM
Authors: Bintari Baiq , Dipokusumo Bambang , Hidayati Asri
Published: September 2021

Analisis Nilai Tambah dan Penyerapan Tenaga Kerja pada Agroindustri Abon Berbasis Ikan di Kota Mataram, bertujuan untuk : (1) Untuk menganalisis penyerapan tenaga kerja pada agroindustri berbagai jenis abon ikan di Kota Mataram, (2) Untuk mengkaji nilai tambah pada agroindustri dari berbagai jenis abon ikan di Kota Mataram, (3) Untuk mengetahui kendala apa saja yang di hadapi pelaku usaha agroindustri abon ikan di Kota Mataram. Penelitian ini menggunakan metode deskriftif dengan teknik survei. Hasil penilitian ini menunjukkan: (a) Penyerapan tenaga kerja (HKO) masing–masing jenis abon ikan yaitu abon ikan  marlin(1), abon ikan marlin(2), abon ikn tuna(1), abon ikan tuna(2), abon ikan gabus, abon ikan tenggiri, abon ikan tongkol, abon ikan asin, abon ikan cakalang dan abon ikan lele, diurutkan; 0,10 HKO/kg dan 2,571 HKO/pp; 0,10 HKO/kg dan 2,857 HKO/pp; 0,10 HKO/kg dan 2,571 HKO/pp; 0,10 HKO/kg dan 1,714 HKO/pp; 0,10 HKO/kg dan 2,714 HKO/pp;  0,10 HKO/kg dan 2,571 HKO/pp;  0,10 HKO/kg dan 2,571 HKO/pp; 0,10 HKO/kg dan 2,429 HK0/pp; 0,10 HKO/kg dan 2,143 HKO/pp;  0,10 HKO/kg dan 2,000 HKO/pp. (b) Nilai tambah untuk abon ikan marlin(1), abon ikan marlin(2) abon ikan tuna(1), abon ikan tuna(2), abon ikan gabus, abon ikan tengiri, abon ikan tongkol, abon ikan asin, abon ikan cakalang dan abon ikan lele, diurutkan :               Rp 21.417/kg bb; Rp 26.317/kg bb; Rp 20.725/kg bb; Rp 24.975/kg bb;                    Rp 31.900/kg bb; Rp 15.150/kg bb; Rp 24.675/kg bb; Rp 14.325/kg bb; Rp 8.900/kg bb dan Rp 26.200/kg bb. (c) Kendala yang dihadapi adalah mendapatkan bahan baku ikan gabus. Disarankan kepada pelaku usaha abon ikan untuk mencoba memasarkan produk melalui media sosial agar jangkauan pemasaran produknya menjadi lebih luas dan mengharapkan terjadinya peningkatan permintaan produk agar terjadi penambahan tenaga kerja pada usaha agroindustri. Diharapkan pemerintah dapat membantu dalam memenuhi bahan baku yang sulit ditemukan, agar pelaku usaha dapat memenuhi permintaan pasar.
KONTRIBUSI KEGIATAN PRODUKTIF PEREMPUAN TANI TERHADAP PENDAPATAN RUMAHTANGGA PETANI DI KECAMATAN PEMENANG KABUPATEN LOMBOK UTARA
Authors: Afriantini Afriantini , Supartiningsih Sri , H.Talib Anwar
Published: September 2021

Keragaan kegiatan ekonomi produktif perempuan tani dapat memberikan kontribusi yang sangat berarti bagi rumahtangga petani, berdasarkan alasan tersebut  penelitian ini bertujuab : (1) Untuk menganalisis pendapatan perempuan tani dari berbagai jenis kegiatan produktif, (2) Untuk menganalisis kontribusi pendapatan perempuan tani terhadap pendapatan rumah tangga petani di Kecamatan Pemenang Kabupaten Lombok Utara.

Metode yang digunakan dalam penelitian ini adalah metode deskriptif dengan unit analisis adalah rumah tangga petani. Daerah penelitian ini ditentukan secara purposive sampling, yaitu: Desa Pemenang Barat dan Desa Pemenang Timur. Penentuan  jumlah  responden  ditetapkan dengan metode quota sampling

Hasil penelitian menunjukkan bahwa: (1) Kegiatan produktif perempuan tani meliputi: kegiatan pada usahatani sendiri sebanyak 20 orang (47,5 %), dengan rata-rata pendapatan per bulan Rp. 169.465;  berdagang sebanyak 11 orang (27,5 %) dengan rata-rata pendapatan Rp. 3.609.500; pengolahan VCO sebanyak 9 orang          (22,5%),  rata-rata pendapatannya Rp. 803.121; dan jasa 3 orang (7,5%), dengan rata- rata pedapatan per bulan Rp. 1.600.000. (2) Kontribusi pendapatan perempuan tani terhadap pendapatan rumah tangga petani sebesar 52,85%, kontribusi terbesar bersumber dari kegiatan berdagang.
ANALISIS TINGKAT KETAHANAN PANGAN RUMAH TANGGA PETANI SAWAH IRIGASI DI DESA CENDI MANIK KECAMATAN SEKOTONG KABUPATEN LOMBOK BARAT
Authors: Sumarni Sumarni , Ayu Candra , Tajidan Tajidan
Published: September 2021

Kecamatan Sekotong merupakan daerah terluas di Kabupaten Lombok Barat. Berdasarkan data Badan Pusat Statistik (BPS) Kabupaten Lombok Barat bahwa produksi padi Kecamatan Sekotong berada pada urutan ke-6 terbanyak. Guna meningkatkan produksi pertanian di wilayah ini, pemerintah membangun beberapa irigasi (embung). Penelitian dilakukan di Desa Cendi Manik Kecamatan Sekotong dengan metode purposive sampling. Pengumpulan data dilakukan melalui wawancara dan dari dinas terkait. Hasil penelitian menunjukkan bahwa rata-rata total pendapatan rumahtangga petani sawah irigasi sebesar Rp 17.734.644/tahun, sedangkan rata-rata pengeluaran rumah tangga petani sawah irigasi sebesar Rp 14.208.012/ tahun; kondisi ketahanan pangan rumah tangga petani sawah irigasi tergolong rawan pangan sebanyak 15 responden (75%), kurang pangan sebanyak 2 responden (10%), rentan pangan  sebanyak 3 responden (15%), dan tidak ada responden yang tergolong tahan pangan; masalah yang dirasakan oleh petani sawah irigasi dalam mewujudkan ketahanan pangan rumah tangga yaitu pada aspek lingkungan fisik saja berupa ketersediaan air sebanyak 9 responden (45%), kesuburan tanah (40%), dan hama penyakit sebanyak 3 orang (15%). Disarankan kepada pemerintah, memberikan sosialisasi dan bimbingan secara berkelanjutan mengenai pentingnya mewujudkan ketahanan pangan rumah tangga dengan mengkonsumsi makanan yang mengandung kalori dan protein cukup.
Inovasi Pelayanan Publik Dinas Penanaman Modal dan Pelayanan Terpadu Satu Pintu Kabupaten Pandeglang
Authors: Suryana Sifa , Agustino Leo , Arenawati Arenawati
Published: September 2021

This Paper about public service Innovation of the investment Office and One Stop Integrated Service of Pandeglang Regency (Case Study of the Public Service Mall in Pandeglang) the purpose of the Public Service Mall This is for the realization of public services that are fast, easy, cheap, transparent by involving vertical agencies, State-Owned Enterprises / Regional-Owned Enterprises, and the private sector in one place. This study uses the theory of Rogers (in Nurdin, 2019: 30) five variables: relative advantage, compatibility, complexity, trialability, and observability. Approach The research used is a qualitative approach with a case study method. The findings of the research field concluded that the Public Service Innovation of the Investment Office and One Stop Integrated Service of Pandeglang Regency at the Public Service Mall in Pandeglang was not optimal because there were several problems such as the location of the Public Service Mall which was less strategic; the facilities and infrastructure provided are not adequate; service users are not yet fully technology literate; officers still lack discipline in punctuality of service hours, and absenteeism; and the less than optimal efforts of the Office of Investment and One Stop Services in Pandeglang Regency in socializing the Public Service Mall to the public.

Keywords: Innovation, Public Service, Public Service Mall
The Role of BRAF Gene in Cancer: Literature Review and Future Directions
Authors: Ricardo Hsieh
Published: September 2021

The BRAF gene encodes a protein belonging to the RAF family of serine/threonine protein kinases. This protein plays an important role in regulating the MAP kinase signaling pathway, which is involved in cellular development, differentiation, division, proliferation, secretion, inflammatory responses and apoptosis in mammalian cells. Since 2002, the mutation of valine 600 to glutamic acid (V600E) is the most prevalent, and it is found to be recurrent in many cancer types. It is frequently identified cancer-causing mutation in melanoma, colorectal cancer, thyroid carcinoma, non-small cell lung carcinoma, hairy cell leukemia, non-Hodgkin lymphoma, glioneuronal tumors, hepatocellular carcinoma, adenocarcinoma of lung, ovarian cancer, and also others malignancies and some cancer metastasis. In the early 1990s, some researchers began studying MAP kinase signaling pathway involved in controlling cell growth and its role in cancer, and it helped identify targets for new classes of cancer therapy. Later BRAF mutation was found in over 50% of melanomas. The overactive BRAF protein expression looked like an attractive drug target. Elucidating the detailed molecular structure of the mutant protein helped pharmaceutical companies developed selective inhibitors of mutated BRAF, including Vemurafenib and Dabrafenib, which have been approved to treat melanoma by the Food and Drug Administration (FDA). In addition, there is a growing number of targeted agents that are being evaluated to treat various BRAF-mutant advanced cancer (especially melanoma, lung, thyroid and colorectal cancer), including other RAF kinase inhibitors and/or MEK inhibitors. The standard therapy of inhibition of BRAF mutation in advanced melanoma and/or others malignancies, improved clinical benefit compared to chemotherapy. In the meantime, intrinsic and acquired resistances are still key challenges by using these drugs. The future research is heading to understand the mechanisms of the resistance, therefore it will help us to understand diseases biology and continuously bringing new therapeutic strategies for melanoma and/or others malignancies, including other drugs combination and next-generation of BRAF inhibitors.
Penerapan User-Based Collaborative Filtering Algorithm
Authors: Khusna Arfiani Nur , Delasano Krisvan Patra , Saputra Dimas Chaerul Ekty
Published: September 2021

Sistem online memanfaatkan website sebagai media pemasaran. Namun dengan perkembangan teknologi, pemasaran dilakukan dengan online terdapat kendala yaitu banyaknya produk yang tersedia dalam pemilihan produk. Sistem rekomendasi adalah sistem yang menyarankan informasi berguna atau menduga yang akan dilakukan user untuk mencapai tujuannya, seperti mencari teknik yang terbaik dalam memberikan rekomendasi bagi user. Menurut hasil survey yang telah dilakukan terhadap 17 orang pemakai website pemasaran produk Gadget Shield didapatkan 88,20% mengharapkan adanya penilaian user terhadap produk. Penelitian ini akan melakukan pengembangan sistem rekomendasi produk Gadget Shield pada toko Jackskins menggunakan metode User-Based Collaborative Filtering serta menggunakan Euclidean Distance untuk mengukur jarak kemiripan antar User dan Weighted Sum digunakan untuk mencari rekomendasi produk. Diharapkan dengan adanya sistem dapat memudahkan User dalam pencarian produk Gadget Shield terbaik. Guna menghasilkan produk rekomendasi,hasil nilai kemiripaan dilakukan perhitungan dengan algoritma Weighted Sum. Sistem rekomendasi Collaborative Filtering telah diuji menggunakan metode pengujian akurasi Root Mean Square Error (RMSE) dan pengujian User Acceptance Test (UAT). Hasil uji RMSE menunjukkan nilai 0,496 atau akurasinya 90,08%. Hasil pengujian UAT didapatkan 86,86% diterima. Informasi dari proses tersebutlah yang nantinya diharapkan akan bermanfaat sebagai dasar sumber rekomendasi yang akurat.
Developing Application in Anticipating DDoS Attacks on Server Computer Machines
Authors: Anggrawan Anthony , Azhar Raisul , Triwijoyo Bambang Krismono , Mayadi Mayadi
Published: September 2021

The use of server computer machines in companies is primarily a web hosting server that is very easy to experience threats, especially external security threats such as attempts to infiltrate, hacking, viruses, and other malicious attacks. Having a secure server is indispensable for working online and especially if involved in business-related network transactions. The Server's realization to be safe from threats is to protect the server machine's security on the hardware and software side and pay attention to network security that goes to the server machine. Generally, firewall applications on router devices have configuration limitations in securing the network, namely non-integrated applications. In other words, it is necessary to manage the perfect firewall configuration to anticipate Distributed Daniel attacks of Service (DDoS) attacks. Therefore, this study aims to integrate existing firewall applications for router devices into an integrated program to secure the network. The methodology used is the Network Development Life Cycle (NDLC). The research results on this developed application program can overcome DDoS attacks without setting up a firewall on the router device and can automatically monitor DDoS attack activities from outside the Server. Securing servers from DDoS attacks without setting up a firewall on the router device and automating the monitoring of DDoS attack activity from outside the Server are the novelties of this study that have not been available in previous studies.
Tractor Transmission Design With KISSsys Model
Authors: ERSARI Müjdat , SARI Selahattin , TUĞRU Ali İlker , ERKEK Hüseyin
Published: September 2021

A tractor transmission is usually very complex with a lot of gear pairs, shafts and bearings in it. Modern transmissions have also several functionalities like shifting without clutch, 4WD/2WD forward/reverse shuttle and PTOs. They must work smoothly and quietly like an automotive transmission, but usually working condi-tions are much more severe. They must also be reliable in different kind of working conditions and fields of applications. Due to the wide variety of gears and speeds that can be chosen, calculations for safety factors and lifetime of components are typically very complicated, time consuming and difficult to manage. It is laborious, unproductive and error-prone to administer the many calculations that occur in a tractor transmission due to its complexity. The use of a calculation model, that sim-ultaneously administrates all the calculations, brings many advantages for the man-ufacturing process, planning of tests and sales support. A very complex and modern transmission was modeled in this project in order to be able to simultaneously meas-ure the entire tractor transmission driveline. Tractor with 12x12 driveline shifting system and power flow variations can be calculated the whole system’s gears, shafts, bearings with a load spectrum.
Contributions of Productivity and Relative Price Changes to Wheat Profitability Changes in China
Authors: Xiu-Shuang Li , Kang Yu
Published: September 2021

Using the provincial panel data of wheat from 1998 to 2018, based on the total price and quantity framework proposed by O'Donnell(2010), and using Färe-Primont productivity index, this artical decomposes the change of wheat profitability into the change of input-output relative price (TT) and the change of total factor productivity (TFP), and further decomposes the change of TFP into technological progress and efficiency change based on input orientation. The results showed that the overall profitability of wheat decreased by 24.9% compared with 1998, which was attributed to the decrease of TT by 32.6% and the increase of TFP by 11.4%. Results indicate that profitability change is mainly driven by TT change, and the impact of TT change on wheat profitability was alleviated by the compensatory change of TFP. The main driving factor of wheat TFP growth is technical progress, Compared with the growth of technical progress, the technical efficiency grows slowly.
Influence of Wetting Additive Based on C12 - C14 Alkyl Ester Sulphate with Essential Oils on the Quality of Nickel Coating
Authors: Šestan Indira , Ogri? Demira Bedak , Odobaši? Amra , Bratov?i? Amra , Obrali? Ema
Published: September 2021

The influence of wetting additive based on C12 - C14 alkyl ester sulfate with essential oils on the quality of nickel coatings is examined in the paper. The additive was tested at different concentrations added to the base electrolyte, taking the following concentrations: the concentration recommended twice lower (C1); lower recommended concentration (C2); upper recommended concentration (C3); the concentration twice higher compared to the lower recommended (C4) and the concentration twice higher compared to the upper recommended (C5). The value of the surface tension of the solution was determined, and the corrosion resistance in the salt chamber was examined. In addition, what is important in the production itself is the visual appearance of the coating, which was determined using the Hull cell test.

The additive has been proven to be effective in reducing the surface solutions, which directly affects the production of nickel coatings of better quality and aesthetic appearance.
Investigation of Some Immunological Markers in Covid-19 Vaccinated Individuals: A Review Article
Authors: Hasan Sulaiman M.
Published: September 2021

The COVID 19 pandemic has caused great havoc amongst the people in society across the globe. It has affected people both physically and emotionally. The epicentre of the virus has been attributed to Wuhan, from where it spread in the different parts of the globe. Vaccination emerged as one of the best solutions to deal with the proliferation of the virus. It also helped people to protect themselves against hospitalization and reduced death rates. The researcher has used Secondary sources to gather information and data related to the immunological markers in Covid-19 vaccinated population. A major immune marker is the manufacturing of neutralizing antibodies. However, the further implication in this aspect is still under research by scientists.
Mixed anxiety-depressive adaptation disorders in the presence of the COVID-19 epidemic
Authors:   Republican national enterprise on the right of economic jurisdiction “Republican scientific and practical center of mental health” of the Ministry of Health of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan, Negai Nikolay , Raspopova Natalya ,   Kazakh Medical University of Continuing Education JSC, Almaty, Republic of Kazakhstan, Altynbekov Kuanysh ,   Republican national enterprise on the right of economic jurisdiction “Republican scientific and practical center of mental health” of the Ministry of Health of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan, Dzhamantayeva Maria ,   Kazakh-Russian Medical University non-profit educational institution, Almaty, Republic of Kazakhstan, Logacheva Natalya ,   Republican national enterprise on the right of economic jurisdiction “Republican scientific and practical center of mental health” of the Ministry of Health of the Republic of Kazakhstan, Almaty, Republic of Kazakhstan
Published: September 2021

In the presence of the COVID-19 epidemic, due to quarantine measures, millions of people around the world are under the stress of infection and have to adapt to new conditions of social functioning. The high risk of developing of mixed anxiety-depressive adaptation disorders in the presence of COVID-19 quarantine measures determines the relevance of this study. Study purpose. To study the prevalence and clinical level of mixed anxiety-depressive disorders in medical personnel under the COVID-19 quarantine regime. Material and methods. 51 employees of the Republican national enterprise on the right of economic jurisdiction “Republican scientific and practical center of mental health” (RSPCMH) were examined: doctors, junior and medium-level medical personnel. The main study method is psychometric (Hospital Anxiety and Depression Score – HADS). Results and discussion. The work presents an analytical review of literature data on the problem of adaptation disorders and current international studies on mental disorders in medical workers under the COVID-19 quarantine regime. According to the results of this study, affective disorders in the form of depressive and anxiety-depressive reactions within the framework of adaptation disorders were detected in 37.3% of the medical staff of the RSPCMH. Conclusions. It was found that the higher the risk of COVID-19 infection, the more often depression is detected and in departments with a lower risk of infection, more often mixed anxiety-depressive disorders are detected. Preventive measures aimed at increasing the stress tolerance of medical workers are recommended. Key words: COVID-19, stress, adaptation disorders, anxiety, depression, stress protectors, tranquilizers.
Structural choroidaid changes in diabetic retinopathy
Authors:   Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Magazova Aizhan , Balmukhanova Aigul ,   Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan, Kanafyanova Elmira ,   Kazakh Scientific Research Institute of Eye Diseases, Almaty, Republic of Kazakhstan, Shargorodskaya Irina ,   National Medical Academy of Postgraduate Education n.a. P.L. Shupic, Kiev, Ukraine, Sharipov Kamalidin ,   M. Aitkhozhin Institute of Molecular Biology and Biochemistry, Almaty, Republic of Kazakhstan
Published: September 2021

Blindness and low vision, as a social medical problem, occupy one of the leading places in both healthcare and the state economy. Diabetic retinopathy (DR) is a vision-threatening microvascular disease, the most common diabetes complication that affects the retina, causing blindness among working-age adults in developed countries. Difficulties in determining the starting, key pathogenetic links and early diagnosis of this disease do not allow to accurately determine the initial moment of occurrence, and known treatment methods are aimed, as a rule, at slowing down the pathological process. Purpose. Analysis of literature data on the clinical and diagnostic features of diabetic retinopathy. Material and methods. To analyze the literature, information was searched on this problem up to 10 years deep in PubMed / MEDLINE, PMC, Web of Since. For the search, the following terms were used individually or in combination: "diabetes mellitus", "diabetic retinopathy", "diabetic vasculopathy", "optical coherence tomography", "fluorescence angiography", "complications". The search criteria were key studies related to diabetic retinopathy, vasculopathy: meta-analyzes, original studies, retrospective and cohort studies. Results and discussions. Oxygen from the capillary layer of the choroid through the Bruch membrane and retinal pigment epithelium (RPE) gets to the outer retinal layers. Due to complications in the bloodstream, nutrition is impaired which leads to diabetic retinal changes. It is advisable and necessary to study changes in the structures of the choroid in large samples using angio-OCT, since changes in the choroid can be the primary prognostic markers of the development of diabetes in the absence of clinical manifestations of diabetic retinopathy. Conclusion. Changes in the structure of the choroid can become a marker for predicting the development of DR in patients with type 2 diabetes, more accurately and quickly establish a diagnosis in the early stages of the disease, and prescribe appropriate therapy in a timely manner. As a result, patients receive timely care and treatment costs will decrease. Keywords: diabetes mellitus, diabetic retinopathy, choroid, diabetic choriopathy, OCT angiography, choroid structures.
Acceptance and adherence to COVID-19 preventive measures are shaped predominantly by conspiracy beliefs, mistrust in science and fear - A comparison of more than 20 psychological variables
Authors: Hartmann Matthias , Mueller Petra
Published: September 2021

This pre-print-version reports the results of survey-data (n = 374). Information regarding methodology can be found in the document. Abstract:
Konut ve Çevresi Kavramına Yaşam Kalitesi Bağlamındaki Yaklaşımların Değerlendirilmesi
Authors: HATİPOĞLU ŞAHİN Betül , TERECİ Ayşegül
Published: September 2021

İnsanlar ve yaşadıkları çevreyi değerlendiren yaşam kalitesi kavramının kökeni çok eskilere dayanmasına rağmen yapılan araştırmalar öncelikli olarak kavramın uzlaşılan net bir tanımının olmadığını ortaya koymaktadır. Birçok kaynakta yaşam doyumu, genel refah, yaşam memnuniyeti olarak ifade edilen kavramın, farklı kaynaklarda 100’den fazla tanımı kaydedilmiştir. Yaşam kalitesi araştırmaları; bireylerin refah hissini oluşturan etmenlerin nedenlerini araştırma ve etkilerini ortaya koyma, memnuniyet ve memnuniyetsizliğin toplumsal ve mekânsal dağılımına ilişkin bilgi sağlama, araştırma sonuçlarına bağlı etkin politikalar ortaya koyup bu politikaların mekânsal etkilerini takip etme gibi amaçlar taşımaktadır. Tanımlar dışında özellikle farklı ülkelerde ve birçok akademik çalışmada yaşam kalitesi ölçümleri için farklı göstergelerin kullanıldığı görülmektedir. Bu noktada yaşam kalitesi araştırmalarında, kişinin yaşam kalitesinin sosyal çevre ve fiziksel çevre olmak üzere iki temel faktöre bağlı olduğunu ortaya çıkmıştır. Özellikle bireyin mekân ve çevresiyle olan ilişkisi, araştırmaların temel noktasını oluşturmuştur. Bu çalışma kapsamında yapılan literatür araştırmasıyla konut ve çevresi için kullanıcıların memnuniyet düzeylerini ve buna bağlı olarak yaşam kalitesi ölçme amacı taşıyan modeller irdelenmiştir.
Merkeziyetçi Temayüller ve Trabzon’da Modern Kamusal Yapıların İnşası (1937-1944)
Authors: DÜZENLİ Evrim
Published: September 2021

Trabzon, 1930-1940 yılları arasında, geniş kapsamlı bir modernleşme hareketinin içinde yerini alır. Bu, gerek “su işi”, “plan işi” ve diğer altyapı çalışmaları, gerekse kamusal yapıların inşası ile bir biçimselliğe kavuşur. 1940’lara kadar, çıkarılan yasalar, vilayet ve umumi müfettişlik gibi kurumlar tarafından yapılan yönlendirmelerin yanı sıra, belediyenin iç koşulları, şehirdeki bu faaliyetler üzerinde merkeziyetçi bir vurgunun oluşmasında etkilidir. Bununla beraber 1930-1940 tarihleri arasında tutulan Trabzon Belediye Meclisi Zabıtları’na göre, faaliyetlerin bütünüyle bu çizgide sürdürüldüğünden bahsetmek zordur. Nitekim bu dönemde şehrin ihtiyaçlarını karşılamaya dönük Numune Hastanesi (1938), Trabzon Lisesi (1938), Stadyum (1942), Erkek Sanat Okulu (1944) yapılarının inşasına dönük çalışmalar başlarken, inşai koşullar, şehirde “bir başka” modernlik deneyiminden daha bahsetmeyi mümkün kılar.
Çalışmada öncelikli olarak, şehirde bu merkeziyetçi koşullar ve bu koşulların kamusal alandaki bayındırlık faaliyetleri üzerindeki etkisi üzerinde durulmuştur. İkinci olarak; söz konusu kamusal yapılar, aynı dönemlerde şehirde büyük dönüşümler ön gören Lambert planı ile ilişkisi üzerinden değerlendirilmiştir. Son olarak, inşai süreç, her bir yapı için ayrı ayrı ele alınmıştır. Bu şekilde, mimarlığın ve kentin görünür simgelerinin yerel bir bağlamı nasıl ürettiğinin ortaya çıkarılması hedeflenmektedir.
Penerapan M-Banking Dalam Meningkatkan Jasa Dan Layanan Perbankan Di PT. Bank Pembangunan Daerah Sumatera Barat Cabang Pembantu Simpang Haru
Authors: Wardani Okta Via , Dona Elva
Published: September 2021

This study aims to determine how the application of m-banking in improving banking service at PT. Bank Pembangunan Daerah Sumatera Barat Cabang Pembantu Simpang Haru. This study uses as descriptive method in collecting data by interview the Bank. The results of study prove that there is an increas in customers using the m-bnking feature, because it makes it easier and saves customers time in conducting banking transactions
Penyembuhan Jiwa Perspektif Ibnu 'Athaillah as-Sakandari
Authors: Ardiana Rahmah Mega
Published: September 2021

Arus modernisasi merupakan suatu kenyataan yang tidak dapat ditolak. Di era ini, umat manusia banyak dihadapkan dengan berbagai macam problem, seperti gelisah, cemas, stress dan sebagainya. Hal tersebut juga diakibat adanya dorongan pribadi pada diri manusia. Berbagai cara akhirnya di tempuh untuk mengatasi masalah serta mengembalikan kepada kehidupan yang sehat dan tenang. Ternyata, tasawuf memiliki pola tersendiri dalam mengembalikan kesehatan jiwanya. Artikel ini, mendiskusikan mengenai penyembuhan jiwa yang diambil dari distingsi tasawuf Ibnu ‘Athaillah. Metode penelitian yang digunakan dalam kajian literature ini adalah motode kepustakaan dan pengumpulan data. Hasil studi akan menunjukkan bahwa sejatinya Ibnu ‘Athaillah memiliki cara tersendiri dalam menyembuhkan penyakit jiwa. Menurut Ibnu ‘Athaillah, makrifatullah merupakan pencapaian tertinggi dalam penentuan jiwa yang sehat. Sehingga, Ibnu ‘Athaillah memperkenalkan beberapa amalan-amalan yang harus dikerjakan serta ditinggalkan dalam melalui beberapa maqam tasawuf. Tasawuf Ibnu ‘Athaillah dirasa dapat membantu seseorang dalam menngembalikan kesehatan jiwanya. Tulisan ini mencoba mengintegrasikan hubungan tasawuf Ibnu ‘Athaillah dengan psikologi yang dirasa mampu memberikan solusi atas problematika tersebut.
Incorporating Ensembled stacked approach into Automated Machine Learning in an attempt to predict acute ischemic heart disease in patients with atypical chest pain: Secondary analysis of a single-center retrospective cohort study
Authors: Haider Bangash Ali , Fatima Arshiya , Zehra Saiqa , Shah Ali Haider , Abbas Syed Mohammad Mehmood , Khawaja Hashir Fahim
Published: September 2021

Automated Machine Learning is explored to predict AIHD in patients presenting with atypical chest pain with an ensembled stacked approach incorporated.
Intеrnеt Аccеss fоr Childrеn’s Оnlinе Schооling during thе CОVID-19 Pаndеmic аnd Pаrеntаl Mеntаl Hеаlth
Authors: Nguyen My
Published: September 2021

Thе оutbrеаk оf thе cоrоnаvirus disеаsе 2019 (CОVID-19) cаusing milliоns оf pеоplе tо bе infеctеd hаs pоsеd mаjоr public hеаlth аnd gоvеrnаncе chаllеngеs. This study еvаluаtеs thе еxtеnt tо which thе unаvаilаbility оf intеrnеt fоr childrеn tо lеаrn оnlinе during thе pаndеmic аffеcts pаrеntаl psychоlоgicаl wеllbеing. Wе find thаt pаrеnts hаving nо intеrnеt fоr thеir childrеn tо lеаrn оnlinе during tо thе pаndеmic аrе 40.37, 47.22, 43.68, аnd 46.90 pеrcеntаgе pоints mоrе likеly tо fееl аnxiоus, wоrriеd, displеаsеd, аnd dеprеssеd еvеry dаy. Thе study cаlls fоr thе еxpаnsiоn оf suppоrts fоr childrеn аnd fаmiliеs during thе pаndеmic, еspеciаlly fоr disprоpоrtiоnаtеly аffеctеd cоmmunitiеs.
Characterizing psychiatric hypersomnia on campus: contributions of chronotype, insomnia, and tiredness
Authors: Beattie Louise , Rigas Georgios , Biello Stephany
Published: September 2021

Study Objectives: The sleep of students contains several features rendering it worthy of independent investigation. Sleep duration is an important aspect of sleep health and wellbeing, however the assessment of psychiatric hypersomnia has been hampered by the absence of a single unitary scale of this construct. With the recent publication of the Hypersomnia Severity Index, research can now examine this condition in greater detail.Methods: Here we consider how the candidate variables of sleep propensity, fatigue, chronotype and insomnia may be associated with hypersomnia scores in a sample of 140 students. Results suggest that hypersomnia was significantly predicted by these measures, but not age or gender. We then model a pathway from chronotype to hypersomnia, including these factors as potential mediators.Results: Results suggest that hypersomnia was significantly predicted by these measures, but not age or gender. The proposed pathway from chronotype to hypersomnia warrants further study.Conclusions: Future studies should expand upon this preliminary report and consider longitudinally and prospectively how hypersomnia is linked to poor mental health in well-characterized samples of students and other young adults.
Extraction and evaluation of action expression related to person perception using correlational analyses
Authors: Okamoto Masahiro , Eifuku Satoshi
Published: September 2021

Identifying how social knowledge is organized and structured is essential to understanding how we form impressions of other people, store and retrieve memories about others, infer other people’s personalities, or predict their behavior. Along this line, social knowledge is modeled in semantic networks, where traits are linked to multiple behaviors. Although previous research has uncovered fundamental knowledge structures and important cognitive aspects, many findings rely on cognitive tasks that involve researchers’ selecting and pretesting stimuli to ensure that they elicit the desired response in most people. Another way to uncover the knowledge structure that underlies our naturally occurring everyday thoughts is to analyze free responses to open-ended questions. This could allow researchers to objectively evaluate the free-response words and phrases based on co-occurrence. However, few methodological principles are available to adequately guide stimuli selection and semantic association evaluation. This study examined whether a correlational analysis of free responses to open-ended questions reveals our social knowledge structure. First, we used correspondence analysis to extract behavior-descriptive words that exemplify trait concepts (Study 1). Then, we examined associations between the extracted words and several traits using psychological experiments (Studies 2 and 3). We found that extracted verbs were associated with specific traits, suggesting that a correlational approach reveals the structure of social knowledge.
Pemanfaatan Dance Theraphy Dalam Konseling
Authors: Megarina Yulietha
Published: September 2021

Tari adalah salah satu metode yang paling banyak digunakan untuk menyampaikan cerita dan ide dari satu generasi ke generasi berikutnya, Gladding (2016). Tari bisa diterapkan dalam proses konseling, konseling merupakan kegiatan yang dilakukan oleh konselor dan konseli, yang dimana konselor membantu secara optimal mengenai masalah yang dihadapi konseli. Tari dalam proses konseling disebut dengan Terapi tari (Dance Therapy) . Marian Chace (1896–1970) dianggap sebagai pendiri terapi tari dan gerakan modern (Sandel, Chaiklin, & Lohn, 1993 dalam Gladding, 2016) ia memulai pekerjaan terapi tarinya pada awal 1940-an di Rumah Sakit St. Elizabeths di Washington, DC dan menjadi seorang penari profesional sebelum memulai pekerjaannya sebagai terapis tari. Gladding, (2016) berpendapat mengenai penggunaan tarian dan gerakan dalam pengaturan konseling dan terapeutik telah ditemukan bermanfaat bagi klien. Terapi tari dan gerak merupakan bentuk refleks gerak seseorang berasal dari pikiran dan perasaan. Melalui pengetahuan dan dukungan klien, perawat membantu perkembangan dan pengintegrasian pola gerak adaptif baru bersama dengan pengalaman emosional yang diiringi beberapa perubahan.
A General Monte Carlo Method for Sample Size Analysis in the Context of Network Models
Authors: Constantin Mihai Alexandru , Schuurman Noémi Katalin , Vermunt Jeroen
Published: September 2021

We introduce a general method for sample size computations in the context of cross-sectional network models. The method takes the form of an automated Monte Carlo algorithm, designed to find an optimal sample size while iteratively concentrating the computations on the sample sizes that seem most relevant. The method requires three inputs: 1) a hypothesized network structure or desired characteristics of that structure, 2) an estimation performance measure and its corresponding target value (e.g., a sensitivity of 0.6), and 3) a statistic and its corresponding target value that determines how the target value for the performance measure be reached (e.g., reaching a sensitivity of 0.6 with a probability of 0.8). The method consists of a Monte Carlo simulation step for computing the performance measure and the statistic for several sample sizes selected from an initial candidate sample size range, a curve-fitting step for interpolating the statistic across the entire candidate range, and a stratified bootstrapping step to quantify the uncertainty around the recommendation provided. We evaluated the performance of the method for the Gaussian Graphical Model, but it can easily extend to other models. The method displayed good performance, providing sample size recommendations that were, on average, within three observations of a benchmark sample size, with the highest standard deviation of 25.87 observations. The method discussed is implemented in the form of an R package called powerly, available on GitHub and CRAN.
What influences whether parents recognise COVID-19 symptoms, request a test and self-isolate: A qualitative study
Authors: Woodland Lisa , Mowbray Fiona , Smith Louise E , Webster Rebecca , Amlôt Richard , Rubin James
Published: September 2021

BackgroundUsing test, trace and isolate systems can help reduce the spread of COVID-19. Parents have the additional responsibility of using these systems for themselves and acting on behalf of their children to help control COVID-19. We explored factors associated with the use of England’s NHS Test and Trace service among parents of school-aged children. MethodsOne-to-one telephone interviews with parents (n = 18) of school-aged (4 to 18 years) children living in England between 30 November to 11 December 2020. Data were explored using thematic analysis. ResultsThree themes and eight sub-themes emerged. In terms of recognising symptoms of COVID-19, parents needed prompting before recalling the main symptoms described by the NHS. Parents suggested several factors relating to the nature of the symptom(s) and contextual information that might lead to or prevent them from seeking a test. Although parents supported symptomatic testing, described trusting official sources of information (e.g., Government and NHS websites) and commonly reported no major concerns, minor concerns were raised regarding the accuracy of test results, safety at testing centres and logistics of testing. Parents perceived adherence to testing and self-isolation as pro-social behaviour, although family resources and circumstances impacted their ability to adhere fully. ConclusionsOur study identified several barriers to parents using NHS Test and Trace as needed. Information about the eligibility of testing (main symptoms of COVID-19 and the age of eligibility) needs to be more precise and resources provided to enable families to adhere to self-isolation if the efficiency of test, trace and isolate systems is to be optimised.
Investigation of anti-arthritic activity (in-vitro models) of Hibiscus hispidissimus Griffith
Authors: Shilpa K , Chacko Nimmy , Shetty Prerana , A Sandhya Savithri
Published: September 2021

Aim of the experiment: The present study was designed to investigate the anti-arthritic potential of the plant Hibiscus hispidissimus. Materials and Methods: The aerial parts of the plant was collected, dried and extracted (maceration) with ethanol. Preliminary phytochemical studies were carried out. All the in-vitro models i.e. inhibition of protein denaturation, membrane stabilization and proteinase inhibition were carried out with standard reference drug diclofenac sodium. Result: Dose dependent and significant (p<0.05) anti arthritic activity in in-vitro models were found. Conclusion: The results reveal promising anti arthritic potential of the plant. However further pharmacological investigation using isolated active ingredients can be carried out to confirm its efficacy and mechanism of action.
Cuminum cyminum methanolic extract prevents oxidative modification of low density lipoproteins: Preliminary evidence on its anti-atherosclerotic potential
Authors: Devkar Ranjitsinh , Lagu Kiran , Thadani Jaymesh , Shirsath Kavita
Published: September 2021

The significance of oxidative modification of LDL in the pathogenesis of atherosclerosis and the lack of efficient treatment intervention has led researchers to develop an effective therapy based on natural antioxidants. The present study provides preliminary evidence in support of the anti-atherosclerotic potential of methanolic extract of Cuminum cyminum L. (CC). We found that CC inhibited Cu2+ -mediated LDL oxidation as demonstrated by the ex vivo LDL oxidation kinetic study, the LDL oxidation products (malondialdehyde, lipid hydroperoxide and protein carbonyl), and ApoB fragmentation assay. It can be concluded that, CC efficiently alleviates experimentally induced oxidative changes and modifications of LDL. Since oxidative changes in LDL are prerequisite to onset of atherogenic changes, this study provides preliminary evidence on anti-atherosclerotic potential of CC.