bluuebunny/crossref_metadata_2025 huggingface dataset:
ПОРЯДОК ФОРМИРОВАНИЯ БУХГАЛТЕРСКОЙ (ФИНАНСОВОЙ) ОТЧЕТНОСТИ В СЕЛЬСКОХОЗЯЙСТВЕННЫХ ОРГАНИЗАЦИЯХ
Authors: О.А. Зубарева
Published: November 2024

В статье рассматриваются вопросы формирования бухгалтерской (финансовой) отчетности сельскохозяйственных организаций, подробно раскрыты этапы формирования промежуточной и годовой бухгалтерской отчетности, описана процедура закрытия счетов перед составлением отчетности сельскохозяйственной организации. Описано формирование данных по отдельным статьям бухгалтерского баланса по каждому разделу актива и пассива. Рассмотрены существенные и несущественные ошибки при составлении бухгалтерской(финансовой) отчетности. Раскрывается заполнение формы отчета о финансовых результатах, отчета об изменениях капитала и отчета о движении денежных средств. Проведена взаимоувязка показателей бухгалтерского баланса и отчета о движении денежных средств. Раскрыта характеристика специализированных форм бухгалтерской (финансовой) отчетности сельскохозяйственных организаций. Затронуто нормативно-правовое регулирование формирования бухгалтерской (финансовой) отчетности организаций сельскохозяйственного производства.
ОСОБЕННОСТИ ПРИМЕНЕНИЯ ИНФОРМАЦИОННЫХ ТЕХНОЛОГИЙ ПРИ ПРОЕКТИРОВАНИИ ПРЕДПРИЯТИЙ ОБЩЕСТВЕННОГО ПИТАНИЯ
Authors: О.И. Немыкина , А.С. Немыкина
Published: November 2024

Исследуются вопросы организации автоматизированного проектирования предприятий общественного питания (кафе, рестораны и др.). Анализируется программное обеспечение, применяемое для проектирования и расчета технико-экономических характеристик предприятий общественного питания. Выявляется наиболее предпочтительное программное обеспечение, рекомендуемое для проектирования производственных процессов. Рассматриваются теоретические аспекты проведения технико-экономического обоснования проекта. Описанное в статье программное обеспечение может быть полезно руководителям при организации бизнеса, связанным с созданием предприятия общественного питания.
РОЛЬ ГОСУДАРСТВА В ОБЕСПЕЧЕНИИ СОЦИАЛЬНО-ЭКОНОМИЧЕСКОГО РАЗВИТИЯ: МИРОВОЙ ОПЫТ И РОССИЙСКАЯ ПРАКТИКА
Authors: И.В. Минакова , И.Г. Кузьмичева , В.И. Галигузов
Published: November 2024

Авторами проиллюстрировано, что практическая реализация либеральных и неолиберальных догм в России привела к катастрофическим последствиям. Произошло падение экономического роста, сопоставимое с потерями войны, революции и гражданской войны 1914-1922 гг., массовый отток капитала за рубеж. Выросла дифференциация населения по доходам, индекс Джини практически удвоился по сравнению с его значением в СССР. Опыт развитых стран мира убедительно доказал, что только при активном государственном регулировании экономика способна демонстрировать стабильное конкурентоспособное развитие. Сегодня государству вменяются контроль за ценами, содержание системы здравоохранения, обеспечение достойного уровня жизни пожилых людей и безработных, предоставление стипендий студентам как наиболее уязвимым слоям населения, сокращение разрыва между богатыми и бедными, реализация промышленной, инновационной, экологической политики, поддержка занятости. Основу современного социально-экономического развития России должны составить несырьевые сектора экономики. При этом их развитие возможно лишь при условии реализации протекционистской политики. Об этом убедительно свидетельствует исторический опыт России.
ТЕОРИЯ И МЕТОДОЛОГИЯ ОЦЕНКИ ФИНАНСОВОЙ СОСТОЯТЕЛЬНОСТИ ПРЕДПРИЯТИЯ (НА ПРИМЕРЕ ЗАОр «НП КОНФИЛ»)
Authors: В.С. Земцова , Е.Е. Харламова , С.П. Сазонов
Published: November 2024

В данной статье рассматриваются теоретические и методологические аспекты финансовой состоятельности предприятия. Приводятся методики оценки финансовой состоятельности, а также нормативные показатели, которые помогают выявить финансовую состоятельность предприятия. Проведен анализ финансовой состоятельности предприятия пищевой промышленности на примере ЗАОр «НП Конфил». Предложены пути улучшения финансового состояния предприятия пищевой промышленности.
СИСТЕМА ВНУТРЕННЕГО АУДИТА И ВНУТРЕННЕНОГО КОНТРОЛЯ КАК ИНСТРУМЕНТЫ КОРПОРАТИВНОГО УПРАВЛЕНИЯ
Authors: Т. С. Каргина
Published: November 2024

В настоящих реалиях для эффективного функционирования хозяйствующему субъекта необходимо осуществлять контроль в финансово-хозяйственной деятельности компании, в аспектах сохранности активов и обеспечении безопасности и точности ведения бухгалтерского учета и составления бухгалтерской (финансовой) отчетности. Эти аспекты позволяет контролировать системы внутреннего аудита и внутреннего контроля. Актуальность выбранной темы исследования обусловлена необходимостью определения места и текущего состояния внутреннего аудита и внутреннего контроля в структуре управления компаний, перспектив их развития, изучения механизмов взаимодействия внутреннего аудита со службами внутреннего контроля, а также определением перспектив и основных направлений совершенствования системы внутреннего аудита и внутреннего контроля для российских компаний с возможным привлечением опыта построения данной системы международного образца в практику отечественных предприятий.
ВЛИЯНИЕ РАЗВИТИЯ ЦИФРОВОЙ ЭКОНОМИКИ НА РЫНОК ТРУДА РЕГИОНОВ
Authors: М.В. Рыбкина , Н.А. Ананьева
Published: November 2024

Одна из основных целей региональной политики ‒ вывести экономику региона на стабильный и оптимальный уровень за счет развития цифровой экономики. Цель исследования данной темы ‒ выявление основных тенденций влияния уровня цифровизации региональной экономики на рынок труда. Представлена динамика основных социально-экономических показателей. Проведен анализ численности населения по регионам. Рассмотрены ключевые проблемы развития рынка труда в условиях  формирования цифровой экономики, которая диктует всем  регионам схему  развития новых направлений в экономической сфере. Исследовано влияние цифровой экономики на состояние рынка труда и показан ряд его новых особенностей. Проведен сравнительный анализ Ульяновской, Пензенской, Самарской, Саратовской областей и Чувашской Республики. Показано, как изменения, связанные с цифровой экономикой, влияют на переподготовку и подготовку кадров. Обобщены существующие взгляды влияния цифровой экономики на развитие рынка труда и его направленность. Предлагаются меры по решению проблем, выявленных в результате исследования.
Цифровые технологии как стратегический приоритет развития пространственно-отраслевой структуры региона в современных условиях
Authors: А.Н. Пыткин
Published: November 2024

С принятием в 2019 году Стратегии пространственного развития Российской Федерации стал актуальным вопрос применения цифровых технологий в управлении развитием региональных пространственно-отраслевых структур. В этом аспекте в современных условиях построения в нашей стране информационного общества применение цифровых технологий заслуживает особого внимания, так как они становятся прочной опорой для развития многих видов хозяйственной деятельности и цифровизации отечественной экономики в целом. Определенные успехи в применении цифровых технологий обусловили актуальность данного направления исследования. Цель – разработка классификации цифровых технологий с выделением их назначения в разрезе видов деятельности и уточнение свойств цифровых технологий, обеспечивающих качественно новый уровень представления информации для принятия управленческих решений. В статье даются определения классификационного состава цифровых технологий и их назначения. Результаты исследования могут быть использованы для развития процессов цифровизации в отраслях экономики и усиления их направленности на рост конкурентных преимуществ и технологическое развитие региональных пространственно-отраслевых структур в современной конкурентной среде.
MARKET POWER, BANK-SPECIFIC FACTORS, AND MACROECONOMIC EFFECTS ON BANKING PROFITABILITY IN INDONESIA: BEFORE AND AFTER THE COVID-19 PANDEMIC
Authors: Hayet Hayet , Hanafi Syafiq Mahmadah , Afandi Mukhammad Yazid
Published: November 2024

This paper examines the impact of market power, bank-specific factors, and macroeconomic changes on profitability in conventional and Islamic banking in Indonesia before and after the COVID-19 pandemic. The data was collected quarterly from 6 conventional banks and 6 Islamic banks during the period from the second quarter of 2014 to 2023, and analyzed using a panel data regression model approach. The dependent variable is bank profitability, measured using the return on asset proxy (ROA) and net interest margin (NIM) / net operating margin (NOM); while the independent variables are concentration ratio (CR), third-party funding (TPF), capital adequacy ratio (CAR), non-performing loan (NPL), operating expenses to operating income (BOPO ratio), gross domestic product (GDP), inflation, exchange rate, and dummy variables. The findings demonstrate that the COVID-19 pandemic has had a detrimental impact on both types of banking, with Islamic banking experiencing a more significant impact than the conventional banking. Furthermore, the TPF, BOPO ratio, exchange rate, and inflation have a comparable impact on the profitability in both types of banking. Similarly, the market power, NPL, CAR, and GDP have distinct impact on the two types of banking, demonstrating disparities in operational features and industry competitiveness levels.JEL: L16, E32, G21.
Development of the First-in-Class Degrader of NLRP3
Authors: Keuler Tim , Ferber Dominic , Engelhardt Jonas , Steinebach Christian , Marleaux Michael , Weindl Günther , Geyer Matthias , Gütschow Michael
Published: November 2024

Targeted protein degradation, spearheaded by proteolysis targeting chimeras (PROTACs), has emerged as an auspicious avenue for drug discovery. NLRP3, a key player in innate immunity associated with several inflammatory diseases, has not yet been targeted by PROTACs. This study explores NLRP3 PROTACs as potential therapeutic candidates. We exploited the diaryl sulfonylurea pharmacophore and utilized a thiophene analog of the NLRP3 inhibitor MCC950 for PROTAC assembly. Using CuAAC chemistry, heterobifunctional degraders bearing various linkers and recruiting three different E3 ligases were synthesized. The compounds were evaluated in bidirectional thermal stability assays with NLRP3 and E3 ligases and their cellular activity was determined by assessing IL-1β release and protein abundance of NLRP3, respectively. PROTAC V2 induces a significant VHL-dependent degradation of NLRP3 and constitutes a valuable tool compound for future biomedical research to decipher the intricate details of the NLRP3 inflammasome.
Biocatalytic Synthesis of a Key Chiral Delamanid Precursor using an Engineered P450 Monooxygenase
Authors: Turner Nicholas , Harris Georgia , Taylor Christopher , Finnigan William , Zhao Fei , Ford Grayson , Hutton Amy , Rowles Ian , Green Anthony
Published: November 2024

We report the development of an engineered P450 monooxygenase that mediates a chemo- and stereo-selective alkene epoxidation to generate a key chiral precursor of the anti-tuberculosis drug delamanid. Screening of an in-house P450 monooxygenase panel led to the identification of a BM3 variant, containing five mutations, with activity for the target transformation. Over a single round of laboratory evolution and gene shuffling, three further beneficial mutations were introduced leading to an order of magnitude increase in the de-sired activity, with a total turnover number (TON) of >3000. This newly engineered enzyme generates a chiral epoxide intermediate from an alkene precursor in a single step with 98% e.e. and >97% conversion. Initial efforts to scale the biocatalytic transformation high-lights the potential of the engineered enzyme to provide a more efficient and sustainable route for the manufacture of delamanid.
Facile and Versatile Mechanochemical Synthesis of Indigoid Photoswitches
Authors: Llamosí Fornés Arturo , Danylyuk Oksana , Szumna Agnieszka
Published: November 2024

We demonstrate the application of mechanochemistry in the synthesis of indolone-based photoswitches (hemiindigos, hemithioindigos, and oxindoles) via Knoevenagel condensation reactions. Utilizing ball-milling and an organic base (piperidine) acting as catalyst and solvent for liquid assisted grinding (LAG) conditions, we achieve rapid, solvent-free transformations, obtaining a set of known and previously unreported photoswitches, including highly functional amino acid–based photoswitches, multichromophoric derivatives and photoswitchable cavitands based on resorcin[4]arenes. The reaction under mechanochemical conditions gives moderate-to-high yields and is highly stereoselective leading to Z-isomers of hemiindigos and hemithioindigos and E-isomers of oxindoles. For selected examples, reversible visible-light photoswiching properties have been demonstrated.
Exact entanglement correlation complements the chemical bond description
Authors: Spałek Józef , Hendzel Maciej , Kuterba Piotr
Published: November 2024

We analyze the properties of the exact solution obtained by us recently for the extended Heitler-London model of the chemical bonding in an analytic form. The emphasis, put on defining the two-particle entanglement correlation, and expressing it by the von Neumann entropy, which provides the complementary characterization of the chemical bond and is directly related to the partial atomicity and the true covalency. The newly introduced concepts refine the standard analysis of covalency based solely on the wave-function and related energy description of the bond as a pure state. We show that a gradual evolution of the system with the increasing interatomic distance of the indistinguishable two electrons composing the bond into their distinguishable correspondents in the atomic (dissociation) limit can be traced out systematically. In particular, only by taking into account the atomicity the true covalency vanishes in the latter limit.
EFEKTIVITAS MODEL PEMBELAJARAN CONNECTING, EXTENDING, REVIEW (CER) TERHADAP KEMAMPUAN BERPIKIR KRITIS MATEMATIS SISWA
Authors: Junaede Harisma , Paronda Naimah , Asfar Andi Muhammad Irfan Taufan , Aisyah Aisyah , Nursyam Aisyah
Published: November 2024

Penelitian bertujuan mengetahui efektivitas model pembelajaran Connecting, Extending, Review (CER) terhadap kemampuan berpikir kritis matematis siswa. Metode yang digunakan adalah quasi experiment desain nonequivalent control group desaign dengan populasi seluruh siswa kelas XI MIPA MA As’adiyah Mattirowalie Kabupaten Bone dan sampel terdiri dari kelas XI MIPA 1 dan kelas  XI MIPA 2 ditentukan dengan teknik sampling jenuh. Instrumen yang digunakan yaitu tes soal kemampuan berpikir kritis, lembar observasi keterlaksanaan pembelajaran, lembar observasi aktifitas siswa dan angket respons siswa. Tes kemampuan berpikir kritis dilakukan dengan tahap pre-test dan post-test, baik pada kelas eksperimen maupun kelas kontrol. Dari hasil penelitian diperoleh nilai rata-rata untuk hasil pre-test dan post-test kelas eksperimen adalah 40,68 dan 82,95. Sedangkan nilai rata-rata untuk hasil pre-test dan post-test kelas kontrol adalah 40,91 dan 72,50. Pengolahan data dianalisis menggunakan alat bantu SPSS dengan uji Mann-Whitney pada α (0,05) diperoleh nilai Asymp.sig (2-tailed) post-test 0,05 yaitu sebesar 0,000 yang berarti H0 ditolak dan Ha diterima. Hasil penelitian menunjukkan bahwa model pembelajaran Connecting, Extending. Review (CER) efektif terhadap kemampuan berpikir kritis matematis siswa. Selanjutnya diperoleh hasil uji effect size sebesar 1,12 yang artinya termasuk dalam kategori besar, rata-rata hasil analisis keterlaksanaan pembelajaran sebesar 95,98% (Kategori Sangat Baik) dan rata-rata hasil analisis aktivitas siswa sebesar 96,02% (Kategori Sangat Baik), serta persentase respons siswa terhadap model pembelajaran CER diperoleh hasil sebesar 82,09% (Kategori Sangat Efektif). Berdasakan penelitian dapat disimpulkan bahwa penerapan model pembelajaran Connecting, Extending. Review (CER) efektif terhadap kemampuan berpikir kritis matematis siswa kelas XI MIPA MA As’adiyah Mattirowalie Kabupaten Bone.
ANALISIS PERSEPSI GURU MATEMATIKA TINGKAT SMP -SMA SEDERAJAT DI KECAMATAN SOCAH TERHADAP PENGGUNAAN TIK UNTUK PEMBELAJARAN MATEMATIKA
Authors: Priandini Erlina Sulis , Faulina Ria
Published: November 2024

Teknologi Informasi dan Teknologi (TIK) berperan penting bagi guru dalam segala aspek. Berbagai media TIK dapat digunakan untuk meningkatkan kemampuan, merangsang proses belajar siswa, dan memberikan peluang kepada peserta didik untuk mempelajari konsep secara lebih mendalam terhadap materi yang susah dipahami khususnya matematika. Sehingga peneliti ingin mengetahui persepsi guru matematika dalam penggunaan TIK, guna memberikan gambaran pentingnya TIK dalam proses pebelajaran. Jenis penelitian ini berupa mixed method dengan subjek penelitian 10 guru Matematika tingkat SMP dan 5 guru Matematika tingkat SMA sederajat di kecamatan Socah mengenai persepsi guru matematika dalam penggunaan TIK. Teknik pengumpulan data dimulai dari observasi, lalu penyebaran keisioner, dan pelaksanaan wawancara. Instrumen dalam penelitian ini berupa lembar angket dengan teknik analisis data menggunakan statistika deskriptif. Dari hasil penelitian diketahui bahwa persepsi guru terkait pemahaman TIK masuk dalam kategori cukup tinggi dengan rentang skor 75% -  100%. Hal ini dikuatkan pula dengan hasil wawancara dimana guru mampu menggunakan LCD serta membuat media pembelajaran digital sendiri. Namun kendala yang dialami yaitu sarana dan prasarana di sekolah belum memenuhi, seperti kurangnya LCD, komputer, serta didorong faktor siswa kurang paham dalam penggunaan TIK. Dapat disimpulkan bahwa persepsi guru matematika terhadap TIK dalam pembelajaran sangat penting untuk meningkatkan minat belajar siswa.
KEEFEKTIFAN COMPUTATIONAL THINKING DALAM MENINGKATKAN KEMAMPUAN PEMECAHAN MASALAH MATEMATIKA SISWA
Authors: Kaswar Andi Baso , Nurjannah Nurjannah
Published: November 2024

Computational Thinking merupakan kemampuan dasar berpikir untuk siswa serta guru dimana kemampuan tersebut dapat memberikan pola pikir yang baru untuk memperoleh pemecahan masalah serta untuk mengembangkan peluang. Tujuan dari penelitian ini adalah untuk mengetahui efektifitas computational thinking terhadap kemampuan pemecahan masalah siswa. Penelitian ini merupakan penelitian kuantitatif dengan pretest postest control grup desain. Instrumen dalam penelitian ini adalah tes kemampuan pemecahan masalah yang diperoleh berdasarkan soal-soal computational thinking yang dikembangkan oleh Bebras. Teknik analisis data dilakukan dengan uji paired sample t test. Berdasarkan hasil analisis data dengan paired sample t-test diperoleh nilai probabilitas 0,000. Karena nilai probabilitas lebih kecil dibanding  maka dapat dikatakan bahwa computational thinking efektif digunakan untuk meningkatkan kemampuan pemecahan masalah matematika siswa. Dengan demikian, kemampuan computational thinking tidak hanya meningkatkan kemampuan pemecahan masalah siswa, tetapi juga mempersiapkan mereka untuk menghadapi tantangan dalam berbagai bidang studi dan situasi kehidupan nyata yang memerlukan pemikiran kritis, kreatif, dan terstruktur.
PENINGKATAN KEMAMPUAN PENALARAN MATEMATIKA SISWA MELALUI MODEL PROBLEM BASED LEARNING
Authors: Manalu Elsadday Br , Nurdalilah Nurdalilah , Wardani Hizmi , Hasanah Wilda , Hasugian Grace Stela Lely
Published: November 2024

Penelitiaan ini bertujuan untuk meningkatkan kemampuan penalaran matematis peserta didik menggunakan model pendekatan problem based learning. Subjek  penelitian ini adalah seluruh siswa kelas X AKL 1  SMK Negeri 7 Medan yang berjumlah 36 siswa. Penelitian dilaksanakan dalam tiga siklus, yaitu siklus pertama terdiri dari dua pertemuan, siklus kedua terdiri dari dua pertemuan, dan siklus ketiga terdiri dari dua pertemuan. Instrumen yang digunakan dalam penelitian ini adalah pedoman observasi, tes siklus, angket respon siswa, pedoman wawancara, dan dokumentasi. Hasil penelitian menunjukkan bahwa kemampuan berpikir matematis siswa kelas X AKL 1  SMK Negri 7 Medan meningkat dibandingkan pada Siklus I, Siklus II dan Siklus III. Hal ini ditunjukkan oleh 32 siswa atau 89% mengalami peningkatan kemampuan berpikir matematis berdasarkan total skor setiap dimensi kemampuan berpikir matematis. Rata-rata persentase hasil tes meningkat dari 45,95% pada Siklus I menjadi 73,41% pada Siklus II dan  89,52% pada  kategori tinggi pada Siklus III. Berdasarkan observasi, pelaksanaan pembelajaran dengan menggunakan model PBL sudah baik dan sesuai dengan karakteristik PBL. Hal ini tercermin dari peningkatan  rata-rata tingkat keterlaksanaan dari 71,43% pada Siklus I menjadi 85,71% pada Siklus II dan  100% pada Siklus III. Berdasarkan data wawancara dan angket, respon siswa terhadap pembelajaran matematika ditinjau dari kemampuan berpikir matematis tercatat mengalami peningkatan dari Siklus I, Siklus II, dan Siklus III. Model PBL menunjukkan respon positif pembelajaran matematika pada siswa sehingga berdampak pada peningkatan kemampuan penalaran matematis.
PROTOTYPE E-MODUL: MEDIA PEMBELAJARAN BERBASIS REALISTIC MATHEMATICS EDUCATION (RME) BERNUANSA ISLAMI DAN LINGKUNGAN PADA MATERI KOORDINAT KARTESIUS
Authors: Nasution Sri Purwanti , Alda Trilisa , Andriani Siska , Alhaq Arini , JL Ana Risqa
Published: November 2024

Pelaksanaan penelitian ditujukan untuk mengembangkan media pembelajaran berbentuk modul elektronik berbasis Realistic Mathematics Education (RME) yang bernuansa islami dan lingkungan pada materi koordinat kartesius. Pengembangan e-modul dilaksanakan untuk mengetahui kelayakan produk, kemenarikan produk, dan keefektifan produk yang dirancang sebagai media pembelajaran untuk peserta didik. Jenis penelitian ini menggunakan jenis Research and Development (R D) dengan model pengembangan Analysis, Design, Development, Implementation, and Evaluation (ADDIE). Penelitian dilaksanakan dengan menggunakan peserta didik kelas VIII MTs yang dikelompokkan menjadi dua kelompok yaitu kelompok kecil sebanyak 26 peserta didik dan kelompok besar sebanyak 56 peserta didik. Hasil validasi oleh ahli materi mendapatkan nilai sebesar 3,56, selanjutnya hasil validasi ahli media mendapatkan nilai sebesar 3,50. Hasil validasi ahli agama pada e-modul ini mendapatkan nilai sebesar 3,50, adapun hasil implementasi pada kelompok kecil mendapatkan hasil sebesar 3,46 sementara pada kelompok besar mendapatkan hasil sebesar 3,27. Uji efektivitas menggunakan effect size mendapatkan hasil sebesar 0,67 dengan kategori “sedang”.
THE ROLE OF STRATEGIC VIGILANCE IN ACHIEVING COMPETITIVE ADVANTAGE IN THE INSTITUTION - CASE STUDY OF EL SEWEDY CABLES, AIN DEFLA
Authors: Zouarqui Imane , Mouzaoui Abdelkader
Published: November 2024

Objective: This study aims to explore the role of strategic vigilance in achieving competitive advantage for economic institutions by analyzing its ability to provide strategic information about opportunities and threats in the competitive environment.
 
Theoretical Framework: The research is based on theories of competitive advantage, emphasizing strategic vigilance as a modern tool for monitoring, observing, and analyzing the external environment to enhance competitiveness.
 
Method: A descriptive-analytical approach was used, with data collected from a sample of economic institution stakeholders to examine the impact of strategic vigilance across demographic variables such as gender, age, and educational level.
 
Results and Discussion: The findings confirm that strategic vigilance is essential for achieving competitive advantage. No statistically significant differences were found in responses based on gender, age, or educational level, except for significant differences linked to the variable of professional experience.
 
Research Implications: The study highlights the importance of training managers and decision-makers in strategic vigilance, recommending regular workshops and practical applications to improve competitiveness in economic institutions.
 
Originality/Value: This research provides valuable insights into the significance of strategic vigilance as a foundational tool for competitive advantage, offering practical recommendations for its effective implementation in economic institutions.
Exploring the Role of Liver Cancer Stem Cells in Hepatocellular Carcinoma Metastasis
Authors: Fatima Maria , Riaz Maria , Amjad Muhammad , Waqas Muhammad , Raza Muhammad Hashim
Published: November 2024

Metastasis refers to disseminating cancerous tumors from their primary site to distant locations inside the body. Cancer cells must go through a sequence of events called the “metastatic cascade” to develop metastases. Each stage necessitates a unique functional alteration. Cancer stem cells (CSCs) play a crucial role in tumor metastasis, but understanding their dynamic behavior and regulating mechanisms remains incomplete. This review explores the influence of liver CSCs on the biological processes that drive the spread and growth of cancer cells, as described by the “metastatic cascade” concept. Liver CSCs can spread to other organs by undergoing epithelial-mesenchymal transition (EMT). This alteration in the microenvironment facilitates cellular dissemination, immune surveillance evasion, dormancy induction, and subsequent reactivation. To effectively prevent and treat advanced hepatocellular carcinoma (HCC) metastases, it is crucial to understand the heterogeneity and features of liver CSCs involved in these processes.
Real-world Efficacy Analysis of Combined Chinese and Western Medicine in the Treatment of Extensive-stage Small Cell Lung Cancer
Authors: Tan Kai , Zhang Changhui , Zeng Puhua
Published: November 2024

Objective: To explore the efficacy of integrated traditional Chinese and Western medicine in the treatment of extensive-stage small cell lung cancer (ES-SCLC). Methods: Patients who were hospitalized and outpatients in the Affiliated Hospital of Hunan Academy of Traditional Chinese Medicine from April 1, 2018, to April 1, 2023, were selected and screened according to the inclusion and exclusion criteria. A total of 161 patients were included, of which the control group was chemotherapy combined with traditional Chinese medicine (TCM), and the experimental group was chemotherapy + immunotherapy combined with TCM. The primary endpoint of this study was overall survival (OS), and secondary endpoints included progression-free survival (PFS), objective remission rate (ORR), and disease control rate (DCR). SPSS 25.0 statistical software and R software (version 4.2.1) were used for processing and data analysis. Results: The prognosis of patients treated with chemotherapy + immunotherapy combined with TCM was significantly better than that of the chemotherapy combined with TCM group, with median OS (15.07 months vs. 13.3 months, P = 0.02) and median PFS (6.87 months vs. 5.97 months, P = 0.04). Conclusion: Based on adjuvant therapy with TCM, chemotherapy combined with immunotherapy has more advantages than chemotherapy alone in prolonging the median OS and PFS. It can improve the general condition of patients after treatment, enhance their tolerance, and provide basic guarantees for subsequent treatment.
Peran Penyuluh Pertanian Lapang Dalam Keberhasilan Program Pekarangan Pangan Lestari Kelompok Wanita Tani Berkah Wanita Kalurahan Gedangrejo Karangmojo Gunungkidul
Authors: Audria Anggun Melvana , Suwarto Suwarto , Anantanyu Sapja
Published: November 2024

Berjalannya program Pekarangan Pangan Lestari (P2L) didukung oleh peran Penyuluh Pertanian Lapangan (PPL) dalam pelaksanaannya. Kelompok Wanita Tani (KWT) Berkah Wanita telah menjalankan program P2L dari tahun 2021-sekarang dan telah mencapai tahap mandiri. Kendala air menjadi masalah yang dialami oleh kelompok pada saat musim kemarau, namun KWT Berkah Wanita tetap melaksanakan program P2L. Penelitian ini dilakukan untuk mengkaji peran Penyuluh Pertanian Lapangan (PPL) dan dampak keberhasilan program P2L yang dilaksanakan oleh KWT Berkah Wanita. Penelitian ini dilakukan dengan menggunakan metode deskriptif kualitatif, dengan lokasi penelitian yang dipilih secara sengaja di KWT Berkah Wanita, Dukuh Banjardowo, Desa Gedangrejo, Kecamatan Karangmojo, Kabupaten Gunungkidul. Informan dalam penelitian ini adalah tiga orang PPL, Dinas Ketahanan Pangan Kabupaten Gunungkidul yang membawahi program P2L, Kepala Dukuh Banjardowo, dan 12 orang anggota KWT Berkah Wanita. Data dikumpulkan dari bulan September-November 2023 dan dianalisis menggunakan teknik Miles dan Huberman (1984) dengan keabsahan data menggunakan triangulasi. Hasil penelitian menunjukkan bahwa PPL pada tahap penumbuhan dan pengembangan berperan sebagai pembimbing, organisator, teknisi dan konsultan. Peran PPL pada tahap kemandirian adalah sebagai pembimbing dan konsultan, serta sebagai teknisi dan organisator.
Autochthonous dengue outbreak in Marche Region, Central Italy, August to October 2024
Authors: Sacco Chiara , Liverani Augusto , Venturi Giulietta , Gavaudan Stefano , Riccardo Flavia , Salvoni Giovanna , Fortuna Claudia , Marinelli Katia , Marsili Giulia , Pesaresi Alessia , Grané Carla Molina , Mercuri Irene , Manica Mattia , Caucci Sara , Morelli Daniela , Sebastianelli Lolita , Marcacci Maurilia , Ferraro Federica , Di Luca Marco , Pascucci Ilaria , Merakou Christina , Duranti Anna , Pati Ilaria , Lombardini Letizia , Fiacchini Daniel , Filipponi Giorgio , Maraglino Francesco , Palamara Anna Teresa , Poletti Piero , Pezzotti Patrizio , Filippetti Fabio , Merler Stefano , Del Manso Martina , Menzo Stefano ,   Marche dengue outbreak group
Published: November 2024

Between August and 28 October 2024, 199 autochthonous cases of dengue virus serotype 2 were notified in the city of Fano, central Italy. We describe the ongoing epidemiological and microbiological investigation and public health measures implemented to contain the outbreak. The high transmissibility and the extension of the outbreak suggest that dengue should be expected in temperate regions during favourable seasons, highlighting the need for heightened awareness among healthcare providers and the public to ensure timely detection and response.
BATTLING THE DARKNESS: COMBATING CHILD SEXUAL ABUSE IN INDIA
Authors: Sharma Bablu Kumar , Kumar Saurabh
Published: November 2024

Child sexual abuse (CSA) continues to remain a widespread and deeply disturbing issue in India, masked by societal taboos, lack of awareness, and gaps in preventing and delivering justice systemically. This doctrinal study explores the legal, social, and policy frameworks addressing CSA in India, examining their efficacy in combating this silent epidemic. The present mechanism under the POCSO Act, 2012, along with traditional legal provisions, is critiqued with respect to both strengths and shortcomings. Their approach needs to be multi-faceted: legal reforms, victim support systems, education for the community, and strictness while enforcing all these measures to bring about a protective environment for children. Addressing cultural stigmas, enhanced reporting systems, and power to survivors are emphasized as the strong steps ahead in lighting the darkness of CSA and putting perpetrators in check for justice and rehabilitation.
ECOLOGICAL AWARENESS IN THE 21ST CENTURY HINDI STORIES
Authors: A.K Bindhu
Published: November 2024

20% of the population of developed countries consumes 80% of the earth's resources and 80% of the rest of the world lives on 20% of the resources. The more resources are consumed, the more pollution will spread. To produce industrial products, man has started exploiting nature and creating a new culture by separating from it. Environmental destruction is its dangerous consequence. When the exploitation of nature started questioning the existence of humans, its response started reflecting through literature. The capitalist mentality that takes away the right to live by unfairly exploiting nature is visible in the literature of the twenty-first century. A culture moving towards development versus destruction shows the decline of the entire human race. The stories of the twenty-first century draw our attention to this horrific reality. Mangosil is proof of this.
AN OUTLOOK OF FEMINISM MOVEMENT IN THE SELECT NOVELS OF ANITA DESAI AND SHASHI DESHPANDE
Authors: P. Sakthivel  , N. K. Vivekanandhan
Published: November 2024

Male is scripted as the head of the family, the guide, the provider, the protector and the moral supporter followed from the ancestry to the present days. The woman is taking decision to handle the responsibility being independently when man is started to lose their own duties. Twenty-first centuries shows the major difference of Indian women. There is no threat of doormats or a damsel in distress is erased in patriarchal norms. Based on this insight, the article discusses about the renowned authors who have achieved worldwide recognition by their outstanding contribution to world literature in the last hundred and fifty-years by the Indian novel Anita Desai’s and Shashi Deshpande’s. On their ideology, the term ‘feminism’ refers global and revolutionary ideology. The aim of socio-cultural of feminism perspective shows the liberation of women from male domination in the patriarchal society shows importance in the modern and postmodern literature. The desire of feminist, women to become self-assertion and self-affirmation through their voice of their writing highlight her position in different aspects. These incidents make them to write with inspirational ideologies, social, political or moral, economic. The authors Anita Desai’s and Shashi Deshpande’s critics the class, gender political and psychosexual conflicts is reduce oppression, suppression in the hands of men related women.
ENHANCING STOCK MARKET AWARENESS IN RURAL AND SEMI-URBAN AREAS: A CASE STUDY OF CHICKBALLAPUR AND CHITRADURGA
Authors: Pasha Mujammil , K Leelavathi
Published: November 2024

The stock market is a cornerstone of economic growth and individual wealth generation. However, in rural and semi-urban areas such as Chickballapur and Chitradurga, awareness and participation in the stock market remain low. This study explores the current state of stock market awareness in these regions, identifies barriers to participation, and proposes solutions to enhance financial literacy. Using a mixed-method approach, the study highlights the need for community-based interventions, digital inclusion, and policy support to bridge the awareness gap.
TUNA FISHERIES IN NORTH SULAWESI: PORTRAIT OF FRESH TUNA DIRECT EXPORT
Authors: Posundu Ronald S A , Nurani Tri Wiji , Baskoro Mulyono S , Solihin Iin , Mustaruddin Mustaruddin
Published: November 2024

The North Sulawesi Regional Government implemented a policy breakthrough to enhance the competitiveness of tuna fisheries by facilitating the direct export of fresh tuna from Manado to Japan. However, export operations have not run optimally, as the cargo quota of 20 tons per trip per week has not been achieved which threatens the continuation of the operation. This study aims to describe the current state of direct export of tuna to Japan and to identify the causes of the failure to meet the cargo quota target for direct export of fresh tuna to Japan. The data used in this study were obtained through in-depth interviews with respondents selected using purposive and accidental sampling, as well as direct observation at the research location. The data were processed qualitatively and quantitatively, and then analyzed descriptively. The results of the study revealed a reduction in the export quota from 20 tons per trip per week to 3 tons per trip per week. In 2023, the export reached the average delivery target was only met in three months: March, April, and December, with 3.35 tons, 3.04 tons, and 7.34 tons, respectively. The cause of the issue is the shortage of high-quality tuna raw materials (grade A), which results from fishermen failing to implement proper fish handling methods during fishing operations. Furthermore, the dependence on tuna supplies from PPS Bitung. The solution is to enhance the ability of fishermen according to good fish-handling standards and to diversify the supply chain of fresh tuna by sourcing from both within and outside the North Sulawesi region.
Keywords:       direct export, fresh tuna, North Sulawesi
EFFECTIVENESS OF THE OIL TO GAS FUEL CONVERSION PROGRAM FOR FISHERMEN IN PALEMBANG CITY
Authors: Shelia Shelia , Sriati Sriati , Priyanto Gatot , Widiastuti Indah , Fariani Armina
Published: November 2024

The Oil to Gas Fuel Conversion Program aims to make it easier for fishermen to obtain fuel at affordable prices, hence they can increase their income. Program implementation is declared effective if it runs smoothly and produces the expected results. This research aims to analyze the effectiveness of the program, analyze the income of program recipients and non-program recipients, and analyze the relationship between program effectiveness and income. Interviews using questionnaires were conducted with research subjects, namely 51 members of the Joint Business Group who received the program and 30 members who did not receive the program. Data in the form of attitudes or opinions of program recipient respondents are analyzed based on the achievement of effectiveness scores, income data from two groups of respondents were analyzed based on the difference between two means tests, and the relationship between effectiveness and income was analyzed based on the Spearman rank correlation test.  The research results showed that the program's effectiveness was 94.20% (very high). The t-count value of 4.816 is greater than the t-table of 1.994, indicating that there is a significant difference between the income of program recipients and non-program recipients. The relationship between program effectiveness and income is very weak and not significant, with a coefficient value of 0.032. The effectiveness of the program does not directly affect income, but the existence of the program increases fishing efforts and the income of program recipients.
Keywords: Conversion; effectiveness; fishermen; gas fuel; Spearman Rank Correlation Test
Trabajo cooperativo en educación física: un enfoque para mejorar las
relaciones sociales en adolescente
Authors:   Universidad CEU
                        Cardenal Herrera de Elche, Aracil Alcocer Rafael , Nestor Alonso Villodre
Published: November 2024

La finalidad de este estudio es investigar si el trabajo cooperativo en
las clases de educación física ayuda a mejorar las relaciones sociales en
adolescentes. Para eso dos grupos de estudiantes de secundaria realizaron
diversas preguntas de la batería de socialización – autoevaluación BAS-3. El
grupo control tuvo las clases de educación física con un enfoque
competitivo, mientras que el grupo experimental utilizó el trabajo
cooperativo en las clases de educación física. Los alumnos realizaron el
cuestionario después de terminar la intervención didáctica. Tras los
resultados obtenidos se concluye que el trabajo cooperativo sí que mejora el
retraimiento social, pero no la ansiedad social, timidez y autocontrol en
las relaciones sociales.
La iconografía musical como contexto para la formación organológica de
maestros de música: una experiencia desde el patrimonio artístico
sevillano
Authors:   Centro Cardenal Spínola
                        CEU, Mondéjar Muñoz Laura , Soria-Vílchez Alejandro ,   CEU Cardenal
                        Spínola
Published: November 2024

Esta propuesta implica la unión entre el arte y el patrimonio pictórico
sevillano como herramienta para la adquisición de contenidos didácticos
específicos de dos asignaturas enmarcadas en la mención en Educación
musical. A través de la iconografía musical como recurso, y mediante una
metodología de observación y análisis guiada por el docente, se propone un
esquema para la comprensión de conceptos organológicos, históricos e
interpretativos desde la colección permanente del Museo de Bellas Artes de
Sevilla.
PEMANFAATAN APLIKASI DIGITAL DALAM PENGENDALIAN BARANG PERSEDIAAN PADA UMKM
Authors: Handajani Lilik , Husnan Lalu Hamdani , Sokarina Ayudia , Fitriani Baiq Titin
Published: November 2024

UMKM Art interior merupakan salah satu bentuk usaha dalam memenuhi kebutuhan masyarakat terhadap produk-produk art interior dan home decoration. UMKM ini mengelola jumlah produk yang banyak dengan ragam jenis persediaan barang yang dikelola secara manual melalui pencatatan pembukuan dan kartu stok.  Kesalahan perhitungan persediaan akhir, lambatnya perputaran persediaan, tidak tersedianya data persediaan real-time maupun kerugian atas persediaan usang merupakan permasalahan yang sering kali terjadi dalam mengelola barang persediaan. Tujuan kegiatan pengabdian masyarakat ini adalah melakukan introduksi manajemen persediaan melalui penggunaan aplikasi digital barang dan persediaan kepada pelaku usaha sehingga dapat memberikan kemudahan dalam pengawasan dan pengendalian terhadap persediaan barang. Kegiatan dilakukan dalam bentuk edukasi dan pendampingan penggunaan aplikasi barang dan persediaan kepada pelaku usaha.  Hasil kegiatan pengabdian masyarakat ini menunjukkan bahwa dengan mampu memanfaatkan aplikasi digital barang dan persediaan pelaku usaha dapat mengidentifikasi persediaan jumlah dan jenis barang dagangan yang beragam, memantau mutasi barang dagangan serta pengawasan internal dan evaluasi terhadap pengendalian persediaan. Dengan pemahaman dan pengetahuan tentang pemanfaatan aplikasi digital barang dan persediaan, pengelola usaha dapat mengoptimalkan penggunaan secara mandiri.
The Relationship Between Students' Self-Confidence and Their Motivation to Speak English (An Investigation at 11th Grade Students at MA Banat Thohir Yasin)
Authors: Kamilia Kamilia , Prasetyaningrum Ari , Arfah Hajriana , Usuluddin Usuluddin
Published: November 2024

This study aimed to find out wheter there was any correlation between students’ self-confidence and their motivation to speak English. This research methode was quantitative with the correlational research design. The research took 20 students of the eleventh-grade students at MA Banat Thohir Yasin as the sample. The instruments used to collect the data were questionnaire and speaking test. The questionnaire to assess students’ self-confidence and motivation, while speaking test to assess students in speaking English. To analyze the data, the researcher used correlations Pearson Product Moment to find out the correlation between students’ self-confidence and their motivation to speak English. The research used SPSS 25 programs as the statistical program to analyze the data. The data found that (1) there was correlation between students’ self-confidence and speaking with the signifcant value was 0.001 < 0.005 and the correlation coefficient r = 0.666. (2) there was correlation between students’ motivation and speaking with the significant value was 0.000 < 0.005 and the correlation coefficient r = 0.904. From the result of the research, it can be concluded that there was a significant correlation between self-confidence and their motivation to speak English.
A transformação da China: autofortalecimento, modernização e crise
Authors: Santos Marco Aurélio dos
Published: November 2024

Em seus esforços para teorizar a Modernidade como um período historicamente distinguível, Reinhart Koselleck – uma das principais referências do arsenal teórico discutido pelo Lab-Mundi – sugere que duas de suas principais características seriam a temporalização e a politização do vocabulário político-social.
A Guerra de Sessenta Anos. A região-mundo platina e as causas do conflito de 1864
Authors: Soares Rodrigo Goyena
Published: November 2024

Pouco afeito a grandes demonstrações de força, d. Pedro II, num gesto portanto raro para seu comedimento natural, não manifestou compaixão qual quer por Solano López quando as tropas brasileiras tomaram Assunção em janeiro de 1869.
Esquemas, recursos e agência em Sewell Jr.: uma proposta teórico-metodológica para a pesquisa biográfica
Authors: Guelli Camilla Cristina
Published: November 2024

Com o alargamento dos objetos de pesquisa centrados em biografias e/ou personagens históricas desde a década de 1980, a consolidação de sua possibilidade, validade e proficuidade na historiografia é latente.
OLHARES INTERDISCIPLINARES EM DIMENSÃO HUMANA
Authors: MARQUES HEITOR ROMERO , BORGES PEDRO PEREIRA , CAPIBARIBE ALINE RIBEIRO DA SILVA , GUTIERRES ETNA MARZOLLA
Published: November 2024

A obra que ora se descortina diante dos leitores nasce de um trabalho coletivo, coordenado com zelo e dedicação por profissionais cujas trajetórias acadêmicas e práticas são marcadas por um comprometimento inabalável com a promoção da dignidade humana e o desenvolvimento integral das comunidades. Cada capítulo aqui apresentado reflete, por meio de uma análise criteriosa e científica, as muitas facetas e desafios que envolvem a construção de uma sociedade mais justa e equânime, na qual as questões sociais, jurídicas, educacionais e ambientais são abordadas de maneira integrada, respeitando as particularidades e necessidades de cada contexto.

Prof. Dr. Vladmir Oliveira da Silveira
Estudos limnológicos da Bacia do Médio Mearim em Bacabal e São Luís Gonzaga no Estado do Maranhão, Brasil
Authors: Durans Érika Luana Lima , Chagas Silva Maria Raimunda
Published: November 2024

sta dissertação, desenvolvida no âmbito do Programa de Pós-Graduação em Meio Ambiente da Universidade Ceuma, destaca-se como uma contribuição significativa para o campo da limnologia e da gestão ambiental. Ao investigar os parâmetros físico-químicos e biológicos das águas da bacia do Médio Mearim, o trabalho revela a complexidade e as particularidades de um dos mais importantes sistemas hídricos do estado do Maranhão. Os resultados aqui apresentados não apenas ampliam o conhecimento científico sobre a bacia do Médio Mearim, como também oferecem subsídios relevantes para políticas públicas de conservação ambiental e gestão sustentável dos recursos hídricos. A escolha das áreas de estudo – os municípios de Bacabal e São Luís Gonzaga – reflete uma abordagem criteriosa e sensível às questões locais, promovendo um diálogo entre ciência, sociedade e sustentabilidade.
Tareas prácticas de información cuántica mediante el uso de fotones correlacionados en polarización.
Authors:   , Quinteros Moro Felipe
Published: November 2024

La tesis titulada “Tareas Prácticas de Información Cuántica Mediante el Uso de Fotones Correlacionados en Polarización” se centra en la implementación experimental y el análisis teórico de tareas de información cuántica utilizando fotones correlacionados en polarización. El estudio investiga principalmente la estimación de la matriz de proceso de un 4C-FBS (Divisor de Haz de Cuatro Caminos) y la adaptación de los Códigos de Acceso Aleatorio Cuántico (QRAC) a entornos ruidosos. Aspectos clave incluyen:

1. Estimación de la Matriz de Proceso: La tesis explora diferentes bases de medición, como las matrices de Pauli, las matrices de Gell-Mann y las Bases Mutuamente No Sesgadas (MUBs), para estimar la matriz de Choi de los canales cuánticos. El enfoque aprovecha el isomorfismo de Choi-Jamiolkowski para recuperar la matriz de proceso del 4C-FBS.

2. QRAC en Entornos Ruidosos: Se diseñó un montaje experimental que incluye una fuente de fotones entrelazados, un interferómetro sagnac que implementa un canal amplitud damping y filtros estocásticos para mitigar los efectos de este canal en un protocolo de QRAC. Esta investigación contribuye a la comprensión y aplicación práctica del procesamiento de información cuántica, ofreciendo perspectivas que podrían ser útiles para futuros desarrollos en comunicación cuánticas.