bluuebunny/crossref_metadata_2025 huggingface dataset:
Linha de Cuidado Integral sobre Saúde Mental
Authors: Gonçalves Laina Ramos Lau Dell Aquila , Moreira Viviane Pressi , Trench Maria Esther Ramos de Freitas , Rodrigues Simone Menezes , Oliveira Karen Moura Pires de , Gimenez Claudia Regina Monteiro , Simões Suzi Mary Silva , Nogueira Maria Carolina de Raphael , Silva Iza Sherolize Amaral , Oliveira Raquel Paula de , Lorena Allan Gomes de , Meneses Abel Silva de , Ramalho André
Published: April 2023

Objetivo: Apresentar uma proposta de linha de cuidado para saúde mental na rede de atenção à saúde de dois distritos da região sul paulistana. Método: Reuniu-se como um grupo único de trabalho, sete serviços, dentre eles quatro da atenção primária à saúde e três serviços da especialidade (atenção secundária). Foram realizados 18 encontros para discussão, leitura de conteúdo e alinhamentos sobre o tema, visando atender as necessidades de saúde mental do território. Resultados: Através da enunciação dos níveis de atenção à saúde, ações e intervenções de saúde, itinerário do paciente e articulação da rede de atenção à saúde mental na linha de cuidado integral, indicar a proposição de um documento técnico parametrizador e uma matriz para acompanhamento de indicadores de qualidade. Conclusão: A linha de cuidado foi criada considerando os aspectos assistenciais, epidemiológicos e gerenciais da saúde mental, especialmente no fortalecimento da promoção da saúde, prevenção e diagnóstico precoce.
Puasa dan demokrasi: menuju pemilu profetik
Authors: Abrar Abrar
Published: April 2023

Puasa merupakan salah satu ibadah yang sangat istimewa untuk mencapai tujuan muttaqin baik secara pribadi maupun social, termasuk kehidupan berbangsa dan bernegra terlebih khusus dalam context demokrasi oleh karena itu, penulis mengkaji  bagaimana hubungan antara ibadah puasa dengan demokrasi kita di Indonesia. Metode yang dipkai adalah adalah kajian pustaka refrensi berkaittan dengan puasa, demokrasi, profetik, dan pemilu.

Bedasarkan hasil kajian, bahawa puasa dan demokrasi merupakan suatu yang berhubungan erat karena puasa sebagaimana dikemukakan di atas adalah suatu sarana yang berupa serangkaian proses ibadah yang bertujuan untuk membentuk kesalihan individu dan sosial. Maka demokrasi merupakan sebuah sistem pemerintahan yang dilaksanakan dari rakyat, oleh rakyat dan untuk rakyat

tentu dalam hal kesempurnaan kualitas ibadah puasa, hanya meninggalkan makan, minum dan hubungan intim maka tidaklah cukup. Ada beberapa hal yang menjadi pantangan yang harus ditinggalkan untuk mendapatkan kesempurnaan pahala puasa yang dikaitkan dengan pemilu lima hal yang membatalkan puasa dengan istilah –istilah yang popular dalam pemilu seperti  gibah sama dengan kampanye hitam (black compaign), kemudian namimah berkaitan juga dengan kampanye hitam (black campaign), kizb dimaknakan dengan penyebaran berita hoax dan al-nazhru bishahwat  mengakibatkan akan menghalalkan cara apapun yang penting menang seperti money politics, black campaign, curang, dan lain-lain.
Eco Agri Revolution: Practical Lessons and The Way Ahead
Authors: Mehta M.H.
Published: April 2023

The Sustainable Development Goals endorsed by the United Nations, put great emphasis on moving away from heavy input agricultural system to more eco-friendly and balanced farming. Eco Agriculture or Agro Ecology is the approach capable of producing enough food and accessible food without harming the environment. This book is about moving from 'Know How' to 'Do How' and brings about rich experience in industrial research and farm scale demonstrations in different parts of the world to show the practical aspects of Eco Agriculture. Theory and practice and recent developments in the areas of Bio Fertilizers, Bio Pesticides, and Bio Composts and agro-waste management form important base for Eco Agriculture practices. The global scenario of industrial development and future trends are discussed with much authority because of the extensive experience of the Author. Encouraged by field studies and success stories, the Author - who is President of a leading NGO - The Science Ashram and Chairman of a well-known Agri Bio Tech Company, Gujarat Life Sciences - has discussed the global scenario and emerging trends. His now famous 20:20 model of Eco Agriculture (20% more farm production with more than 20% reduction in input costs in a sustainable manner) emerges out of this. Developments and field experiences in Bio shield, Water use efficiencies, ICT, Rehabilitation post disasters like Earth Quake and Tsunami, Saline Water Agriculture and River Revival Projects, Urban agriculture and their common link for Eco Agriculture Revolution makes the book especially significant. Finally, the Author describes the 'Way Ahead' for Eco Agri Revolution including aspects of Soil and Waters and COP 22. The conviction about the coming Eco Agri Revolution and planning and implementation for a sustainable future are the final thoughts that makes this book extremely valuable the current and future generations.
Cucurbits: Biotic and Abiotic Stresses
Authors: Laskar Nripendra
Published: April 2023

“The present book "Current Trends in Global Environment" deals with each and every important and recent issue of environment with clear-cut facts in a lucid manner of presentation, which are likely to be come across by its readers, irrespective of their discipline. An attempt has been made to present the matter in a perceptible and comprehensible manner which would be equally important to a beginner and specialist. Worthy for a reference for its up-to-date content that satisfy its user in a minimum of time. By far majority of books are from the mainstream with heavy a textual load. It has s on present day burning topics like The Greenhouse Effect, Natural Disasters i.e., Tsunami, Earthquake, Continental Drift, Sustainable Environment, Space Ecology, The Glossary will be useful for an individual new to the subject and anyone inexperienced in dealing with some aspects of the subjects. The index has been designed with upper most principle that it should be as complete as possible, of words and short phrases as they naturally appear in related species. We hope that his Global publication by a global famed personality will fit the subject gap for the readers and above all institutional libraries.
Diseases of Field Crops and Their Integrated Management
Authors: Kumar Sanjeev
Published: April 2023

o Each chapter has further been divided into sub-heads such as introduction and economic importance, symptoms on different parts, causal organism, disease cycle and favorable conditions. o Symptoms of important diseases have been illustrated with colored photographs which will help in their correct and easy diagnosis. o Management practices including, cultural, physical, biological, host resistance leading to integrated disease management. o This book will serve immensely for teachers and students in the field of plant pathology.
Drying Technologies for Foods: Fundamentals & Applications: Part Iii (Co-Published With Crc Press,Uk)
Authors: Mujumdar Arun
Published: April 2023

This book is an effort to present in a progressive and systematic form the basic knowledge required both for selection and technical design of appropriate drying systems. This book consists of 15 s; the first is dedicated to fundamental principles and basic terminology of drying followed by s offering a detailed description of different drying techniques and their applications. The challenge of developing advanced drying techniques for the food industry is followed in line with the demand for enhanced food quality and safety. Therefore, further s cover a comprehensive review of the latest developments in different drying technologies and locating the trends in future research and development. These s are written in a very easy to read and understandable language containing clear explanation of every concept and aspect of the same which can be used by undergraduate and graduate students as well as by faculty for teaching purposes. Recent literature is also compiled and discussed to assist researchers and scientists for clear understanding of the concepts in greater detail behind different types of drying techniques. The contributors in this book have worked extensively in respective areas of drying technology and their strong experience will greatly benefit the readers.
Diseases of Horticultural Crops Identification and Management: With Colour Illustrations
Authors: Kumar Sanjeev
Published: April 2023

The book has been written as Text Book for Undergraduate as well as Post Graduate students covering major aspect of horticultural diseases.
Crop Physiology: A Terminology Book
Authors: Boominathan P.
Published: April 2023

There are many textbooks available for plant physiology, difficulty in understanding the terminologies in crop physiology become a hindrance to fully utilizing the textbooks of crop physiology.This book has most of the terminology which is commonly used mainly in Crop physiology  and  also  from  biochemistry,  plant  breeding  &  genetics,  Agronomy, soil  science.  Besides, few statistical terms that are commonly used in biological research also included. This book will be of immense use to the undergraduates and postgraduates'  students  of  agriculture,  biochemistry,  and  botany  and  would  also helpful in various competitive exams including UPSC, TNPSC, Agricultural officers, Horticultural officers  and other exams.
Diseases of Fruit Crops and Their Integrated Management
Authors: Bahadur Amar , Dutta Pranab
Published: April 2023

The book covers different topics of nationally economic importance of diseases of fruits and their management. There is a record of huge losses of fruits in terms of yield and quality, which is caused by different plant pathogens. This edited book will be helpful for the students pursuing their degree in agricultural sciences, growers, teachers, extension personnel's and fellow researchers in their respective fields. This book will also helpful as a ready reckoner on the diseases of fruits.
Doubling Farmers Income Through Animal Husbandry
Authors: Surinder K. Gupta , Amrutkar Suraj , Gupta Vinod
Published: April 2023

The book is written as per requirement of farmers, students of veterinary science and animal husbandry. The book includes updated information on topics highlighted in precise manner, with personal communication touch of authors out of their enriched experience in profession, for considerable long time.This book will serve as handy material for farmers and students as well as to the teachers dealing with undergraduate students in animal science discipline and those appearing for various competitive examinations in animal science, will also find this book equally useful.
Anatomical studies and nutritional analysis of the leaf extract of Plukenetia conophora
Authors: C.E.C. Ugwoke  , SPG Anze  , A.E. Nweze
Published: April 2023

Background and aim: Plukenetia conophora Mull. Arg. (African walnut) belongs to the Euphorbiaceae family. Thesignificance of wood anatomy in relation to taxonomy is by no means new or recent. Aim: The work evaluates theanatomy of the leaf, stem, root and the nutritional values of the leaves of Plukenetia conophora. Methodology: Leafepidermal strips were made by Impression technique and all sectionings (TS, TLS and RLS) were made with Reichertsliding microtome. Standard stains were used to differentiate the tissues. The proximate and mineral analyses werecarried out using standard methods. Results: Anatomical studies showed hypostomatic leaves with anomocyticstomata and no trichomes. Concentric vascular bundles were observed in the transverse sections of the leaf andpetiole. The various sections of the stem anatomy revealed diffuse-in-aggregate vessels with scanty axial parenchymain the transverse section, both uniseriate and biseriate rays in the transverse longitudinal section, and procumbent raysin the radial longitudinal section. Nutritional analysis showed presence of all the tested proximate and minerals. Theleaves contained proximate: carbohydrates (25.57 ± 0.05), protein (18.02 ± 0.02), ash (29.36 ± 0.33), moisture (18.06± 0.03), crude fibre (9.83 ± 0.17) and fat (7.41 ± 0.11) and minerals: calcium (19.18 ± 0.00), potassium (14.01 ± 0.00)and sodium (7.97 ± 0.03), Zinc (0.70 ± 0.01), magnesium (1.91 ± 0.01), iron (4.93 ± 0.04) and manganese (0.91 ±0.00). Conclusion: The anatomical results are quite useful in the delimitation of this species and nutritional resultssuggest the use of the leaves as a healthy food.
GC-MS analysis of methanolic extract of stem and root bark of Kirganelia reticulata for bioactive components
Authors: R. A. Reddy  , V. Krishna  , S. Usha  , R. Bharathi  , V. K. Murthy
Published: April 2023

Objective: To identify the bioactive components present in the stem and root bark extracts of Kirganelia reticulata.Methods: The soxhlet extracted crude methanolic extracts of stem and root bark of Kirganelia reticulata wereanalysed by GC-MS. Results: GC-MS analysis revealed the presence of 27 and 24 potential bioactive components instem and root bark extract of Kirganelia reticulata respectively. These components were mostly esters, phenols,flavonoids, aldehydes, alkaloids, sterols and terpenoids with biological activity. Conclusion: Many of the bioactivecomponents identified in the study are multifunctional in nature with potent antioxidant, antimicrobial, antifungal,antiviral, candidicide, hypocholesterolemic, anti-inflammatory, anti-cancer, anti-androgenic, antiasthma, diuretic andhepatoprotective in nature justifying the use of this plant in traditional medicine for treating various ailments and alsoproviding an opportunity for identification of potential drug candidates
In silico designing of DASM with Pyrazofurin, a possible drug candidate for Anthrax
Authors: Prashantha Karunakar  , K V Shiva Kumar  , C Sunil Kumar  , V Krishna Murthy  , C R Girija
Published: April 2023

Bacillus anthracis is a notorious occupational zoonotic agent causing anthrax to veterinarians.In this study, for the purpose of lead development, Dehydro Andrographolide Succinic acid Monoester (DASM) inhibitor of Furin was selected as a template.Anthrax infection is highly lethal in its most virulent form and produces a combination of three endotoxins namely Protective antigen, Lethal factor and Edema factor.Furin is involved in other diseases, DASM was modified by adding anti-cancer, anti-inflammatory, anti-tuberculosis and anti-viral groups.
Comparative analysis on the quality characteristics of commercially important mango cultivars for canning
Authors: Pratibha Ramdasappa  , Shivashankar Mallaiah
Published: April 2023

Fourteen important mango cultivars (Alphonso, Amarapalli, Banganapalli, Bombay green, Dushri, Kesar, Langra, Malgoba, Mallika, Neelam, Padari,Rumani,Sindhura and Totapuri) grown in Karnataka were selected and their physico-chemical properties were characterized and compared.

Of all fourteen cultivars, Banganpalli mango exhibited significantly (p< 0.05) higher individual weight followed by Bombay Green and Totapuri mangoes respectively. Bombay Green mango presented significantly (p< 0.05) higher content of TSS, pH and total sugars. Alphonso mango had highest pulp content followed by Malgoba and Bombay Green mangoes. The study allowed the fourteen mango cultivars to be differentiated clearly based on all the physico-chemical properties and to use unexploited mango varieties for commercial purpose.
Occupational Ionizing Radiation Effects on Blood Cell Counts among workers engaged in a few Radio-Diagnostic Centers
Authors: Krishnamurthy V  , Vanishree R  , Uma M V
Published: April 2023

Ionizing radiation is being used widely for diagnostic and therapeutic purposes. Continuous and intermittent exposure of technicians to low doses of ionizing radiation can exert measurable changes at the level of cell and chromosomes.In this study, the ionizing radiation prevalent in the work environment at diagnostic labs and the background radiation in general environment of Bengaluru, India was measured using hand-held dosimeter.The blood samples from the normal population and the occupants were also collected and investigated for cellular changes induced by exposure to ionizing radiation. The number of lymphocytes was measured and the CD4+/CD8+ ratio was checked to find any difference between the two groups (control group and the occupants group) of blood samples collected.It was seen that there was no significant difference between the change in the lymphocyte number and also the CD4+/CD8+ ratio among these groups. Conclusion: The study indicates that the prevalent ionizing radiation was at a quite low degree to induce changes at cellular levels; also the exposure was intermittent and not continuous which is also a reason for not noticing cellular changes.
Nanorobots: A Developmental Tool for the Treatment of Cancer
Authors: Ankit Kumar Dubey  , Ligi Milesh
Published: April 2023

This review paper aims at presenting the overall scenario of the present trends and advancements in development in the treatment of cancer. Nanorobots help us in bridging the technological gap between the different fields of sciences on the nanoscale. According to the World Health Organisation, the leading cause of the death in the present scenario is the Cancer. Currently there are two types of treatment processes used for cancer treatment: chemotherapy and radiotherapy. But with the advancement in technology, the nanotechnology has come up with an excellent idea of introducing Nanorobots that use cadherin signals and chemicals along with body heat as their fuel to target and kill the tumour cells. This is a revolution in the field of medical technology and also an alternative to the chemo and radio-therapy, therefore finding a solution to one of the most challenging problems without any side effects.
Phytochemical and histochemical studies on Solanum diphyllum L.- An exotic potent weed
Authors: Raman Verma  , Sharmistha Dutta
Published: April 2023

Plant-based substances are seeking attention due to their substantial medical benefits. Medicinally, as well as in terms of poisoning and psychotropic effects, members of the family Solanaceae have been of great importance and used throughout history. The present study mainly focuses on the identification and location ofan important exotic plant speciesSolanumdiphyllum L. proven to be a potentially fast-spreading weed being reported from various states of South India and the detection of important biologically active chemical compounds in the same to look into the discovery of new herbal formulations and their curative properties for treatment of common ailments.
BOKO HARAM AND TERRORISM IN NIGERIA: REFLECTIONS ON THE ORIGINS, IMPACT AND GOVERNMENT RESPONSE
Authors: YAYLA Mustafa , YAHAYA Aboubakar
Published: April 2023

For over a decade, Boko Haram has emerged as one of the biggest security threats facing not only Nigeria, but the larger Sahel and Lake Chad Basin. Government efforts to counter the group are yet to prove successful in eliminating this threat. This article examines the emergence of Boko Haram from a historical perspective that draws attention to old patterns of political resistance dissimilar to other parts of the country from the colonial era. The study highlights the deep social, economic and political impacts of the organization and reflects on the nature of government response. This article argues that while the emergence of the group has strong attachment to economic and political grievances such as poverty, underdevelopment and political marginalization, it is the framing of these grievances into a radical ideology sustained by entrenched ethnoreligious prisms that sustains Boko Haram terror activities in Nigeria. While the article appreciates the counterterrorism, measures adopted the by government, it also provides a critic of those measures and attempts to offer recommendations on how they can be strengthened to be more effective.
The Mediating Role of Organizational Commitment Between Transformational Leadership, Job Satisfaction, and Turnover Intention among Call Center Agents in Metro Manila
Authors: Tocle Redmund Joseph
Published: April 2023

This study looked at the relationship of transformational leadership and job satisfaction to turnover intention, including the mediating factor of organizational commitment among 87 call center agents in Metro Manila, Philippines. This study used a quantitative-cross-sectional and explanatory design and involved online survey of call center employees as a research method. Respondents were selected through a non-probability sampling technique specifically through snowball sampling or referral method. The results of this research showed a high level of transformational leadership exhibited in call center companies, high level of job satisfaction among call center agents, high organizational commitment but only average turnover intention. Most importantly, this research highlights the important role that organizational commitment as a mediator as the results of this study showed that organizational commitment fully mediates the relationship of transformational leadership and job satisfaction to turnover intention.
“Transporte aos quadradinhos”: O chão como espaço de montagem nos trabalhos de Armanda Duarte
Authors:   Universidade Federal do Espírito Santo, Dias Aline Maria
Published: April 2023

O artigo aborda um conjunto de cinco instalações da artista Armanda Duarte. A reflexão explora o modo como a artista contrapõe o caráter efêmero dos trabalhos e a precariedade de seus materiais com um rigor geométrico ou matemático. As operações de medição e deslocamento articuladas no trabalho, assim como a adoção do chão como espaço de apresentação são questões abordadas no texto, destacando sua vulnerabilidade e a adesão a uma montagem reversível e aberta. O artigo situa o pertencimento deste conjunto de instalações a uma coleção particular em comodato no Museu de Arte Contemporânea da Fundação de Serralves, em Portugal e as diferentes situações de exposição realizadas.
As imediações da paixão na pesquisa: do amor latente ao desejo potente
Authors:   Universidade do Estado de Santa Catarina, Nunes Carolina Ramos
Published: April 2023

Este artigo trata de articulações entre a paixão cega e o amor consolidado dian- te de um problema de pesquisa desde a abordagem metodológica até a delimitação conceitual e de trajetória da pesquisa. Tramando a metodologia com a delimitação de um problema e visibilidade de percursos fortuitos ou não a serem trabalhados no período de dois anos do mestrado, o desejo de pesquisar vincula-se á necessidade de escrever aquilo que foi escrito só que por um viés outro, criando um universo para deleite enamorado.
Pesquisa e Escrita
Authors:   Universidade do Estado de Santa Catarina, Siqueira Juliano Reis
Published: April 2023

Este trabalho, realizado na disciplina Seminário de Pesquisa I, apresenta reflexões referentes à escrita de uma tese de doutorado, articulando as contribuições de Miklos (2011), Freitas (2006), Alves-Mazzotti (2006) e Duras (1994). A partir das discussões em aula e dos textos busca-se pensar a elaboração da tese como um processo de criação, que investiga aquilo que nos fascina e tem a ver conosco, para se chegar além do que somos. O caminho depende de onde queremos chegar.
ESCREVER: UM DESAFIO AOS ALUNOS DA/NA PÓS-GRADUAÇÃO
Authors:   Universidade do Estado de Santa Catarina, Machado Elisete Moccelin
Published: April 2023

O exercício da escrita é um desafio ao pesquisador e ao estudante acadêmico, exige leitura, base teórica, fundamentação, num fazer solitário e perseverante. A pesquisa traz desconforto, desacomodação, entristece, exige muito até chegar ao caminho, ao diálogo - documento, teoria, afetos explicativos, plausibilidades - potências e desejos. A paixão pelo tema e pelo objeto de pesquisa minimizam as dificuldades e facilitam o exercício da escrita, especialmente no quesito disserta- ção ou tese. Escrever é uma construção amorosa, um ponto de partida, de resiliência e de apaixonamento.
MARINELA GARCÍA SEMPERE, ANTONI MAS I MIRALLES, JOAN M. PERUJO MELGAR (edd.), Flos Sanctorum o Vides dels Sants Pares. Legenda aurea en català, Barcelona, Publicacions de l’Abadia de Montserrat, 2022, 304 pp. [ISBN 978-84-9191-211-8]
Authors: Redondo Jordi
Published: April 2023

MARINELA GARCÍA SEMPERE, ANTONI MAS I MIRALLES, JOAN M. PERUJO MELGAR (edd.), Flos Sanctorum o Vides dels Sants Pares. Legenda aurea en català, Barcelona, Publicacions de l’Abadia de Montserrat, 2022, 304 pp. ISBN 978-84-9191-211-8.
‘Haec, quae non vidistis oculis, animis cernere potestis’ . Poggio Bracciolini contro Lorenzo Valla fra performance retorica e self-definition.
Authors: Sasso Ludovica
Published: April 2023

Poggio Bracciolini (1380-1459), segretario apostolico e poi Cancelliere della Repubblica di Firenze, fu indiscusso protagonista del movimento umanistico italiano, distinguendosi anche come maestro d’invettiva. Nell’obiettivo comune di far rivivere l’eredità antica, anche nelle invettive gli Umanisti offrirono numerose rappresentazioni erudite, attraverso ad esempio l’agonale tentativo di aemulatio dei modelli del passato, ma anche l’ostentazione di un significativo virtuosismo retorico. Il presente contributo analizza un episodio della seconda oratio in Laurentium Vallam (c. 1452) del Bracciolini, ove il ricorso alla trattatistica retorica antica in ambito di scrittura figurativa emerge più evidente che in altri loca delle sue invettive e insieme alla riscrittura ‘artistica’ di un famoso passo ciceroniano si staglia come strumento di rappresentazione e distinzione personale per l’umanista di Terranuova.
Early myelination involves the dynamic and repetitive ensheathment of axons which resolves through a low and consistent stabilization rate
Authors: Almeida Adam R , Macklin Wendy B
Published: April 2023

Oligodendrocytes in the central nervous system exhibit significant variability in the number of myelin sheaths that are supported by each cell, ranging from 1 to 50 (1-8). Myelin production during development is dynamic and involves both sheath formation and loss (3, 9-13). However, how these parameters are balanced to generate this heterogeneity in sheath number has not been thoroughly investigated. To explore this question, we combined extensive time-lapse and longitudinal imaging of oligodendrocytes in the developing zebrafish spinal cord to quantify sheath initiation and loss. Surprisingly, we found that oligodendrocytes repetitively ensheathed the same axons multiple times before any stable sheaths were formed. Importantly, this repetitive ensheathment was independent of neuronal activity. At the level of individual oligodendrocytes, each cell initiated a highly variable number of total ensheathments. However, ~80–90% of these ensheathments always disappeared, an unexpectedly high, but consistent rate of loss. The dynamics of this process indicated rapid membrane turnover as ensheathments were formed and lost repetitively on each axon. To better understand how these sheath initiation dynamics contribute to sheath accumulation and stabilization, we disrupted membrane recycling by expressing a dominant-negative mutant form of Rab5. Oligodendrocytes over-expressing this mutant did not show a change in early sheath initiation dynamics but did lose a higher percentage of ensheathments in the later stabilization phase. Overall, oligodendrocyte sheath number is heterogeneous because each cell repetitively initiates a variable number of total ensheathments that are resolved through a consistent stabilization rate.
Shear and hydrostatic stress regulate fetal heart valve remodeling through YAP-mediated mechanotransduction
Authors: Wang Mingkun , Lin Belle Yanyu , Sun Shuofei , Dai Charles , Long Feifei , Butcher Jonathan T
Published: April 2023

Clinically serious congenital heart valve defects arise from improper growth and remodeling of endocardial cushions into leaflets. Genetic mutations have been extensively studied but explain less than 20% of cases. Mechanical forces generated by beating hearts drive valve development, but how these forces collectively determine valve growth and remodeling remains incompletely understood. Here, we decouple the influence of those forces on valve size and shape, and study the role of YAP pathway in determining the size and shape. The low oscillatory shear stress promotes YAP nuclear translocation in valvular endothelial cells (VEC), while the high unidirectional shear stress restricts YAP in cytoplasm. The hydrostatic compressive stress activated YAP in valvular interstitial cells (VIC), whereas the tensile stress deactivated YAP. YAP activation by small molecules promoted VIC proliferation and increased valve size. Whereas YAP inhibition enhanced the expression of cell-cell adhesions in VEC and affected valve shape. Finally, left atrial ligation was performed in chick embryonic hearts to manipulate the shear and hydrostatic stress in vivo. The restricted flow in the left ventricle induced a globular and hypoplastic left atrioventricular (AV) valves with an inhibited YAP expression. By contrast, the right AV valves with sustained YAP expression grew and elongated normally. This study establishes a simple yet elegant mechanobiological system by which transduction of local stresses regulates valve growth and remodeling. This system guides leaflets to grow into proper sizes and shapes with the ventricular development, without the need of a genetically prescribed timing mechanism.
LazyFox: fast and parallelized overlapping community detection in large graphs
Authors: Garrels Tim , Khodabakhsh Athar , Renard Bernhard Y. , Baum Katharina
Published: April 2023

The detection of communities in graph datasets provides insight about a graph’s underlying structure and is an important tool for various domains such as social sciences, marketing, traffic forecast, and drug discovery. While most existing algorithms provide fast approaches for community detection, their results usually contain strictly separated communities. However, most datasets would semantically allow for or even require overlapping communities that can only be determined at much higher computational cost. We build on an efficient algorithm, Fox, that detects such overlapping communities. Fox measures the closeness of a node to a community by approximating the count of triangles which that node forms with that community. We propose LazyFox, a multi-threaded adaptation of the Fox algorithm, which provides even faster detection without an impact on community quality. This allows for the analyses of significantly larger and more complex datasets. LazyFox enables overlapping community detection on complex graph datasets with millions of nodes and billions of edges in days instead of weeks. As part of this work, LazyFox’s implementation was published and is available as a tool under an MIT licence at https://github.com/TimGarrels/LazyFox.
Antropofagia organizacional ou adoção cerimonial? Um estudo de caso em uma estatal de Minas Gerais
Authors: Secco Dany Andrey , Fonseca Simone Evangelista , De Souza Antônio Artur , Xavier Daniele Oliveira
Published: April 2023

A adoção de novas tecnologias gerenciais acarreta mudanças na cultura organizacional, independentemente de ser produto de pressões externas ou internas à organização. A reação organizacional diante da inovação impacta diretamente na apropriação da tecnologia e pode resultar em frustração pelo fracasso do projeto, em uma adoção formal com pouco impacto nos resultados, ou na adaptação criativa do modelo para atender às necessidades e peculiaridades do negócio e da cultura da organização. Com a Lei nº 13.303, de 2016, as estatais federais, estaduais, distritais e municipais se viram na necessidade de adotar práticas de governança corporativa e de gestão de riscos. Práticas com objetivos como transformar a gestão das empresas estatais em uma gestão transparente, definir melhores bases para a responsabilização dos gestores, em caso de desvios, desperdícios ou de não atingimento de resultados, e promover uma cultura de integridade. Assim, é necessário avaliar como as estatais reagiram frente aos ditames da Lei nº 13.303, de 2016, e se essas reações carregam características da adoção cerimonial, de cunho formal, ou de antropofagia organizacional, método de adaptação criativa. Esse estudo propõe verificar a comunicação formal da alta administração da Companhia de Saneamento de Minas Gerais, Copasa, no período entre 2014 e 2018, e analisar as respostas dos empregados a questionário sobre gestão de riscos. Os resultados indicaram antropofagia organizacional na internalização da governança corporativa e adoção cerimonial para a gestão de riscos da empresa.
Ultrasound Versus Magnetic Resonance Imaging for the Detection of Early Rheumatoid Arthritis in A Sub-Himalayan Region of North India: A Cross-sectional Study
Authors: Chowalta Shiwani , Aggarwal Neeti , Kapila Sumala , Verma Balvir Singh , Mahajan Sanjay , Sharma Vikas , Makhaik Sushma
Published: April 2023

Introduction: Rheumatoid arthritis (RA) is a disability disease with predominant involvement of hands and feet. It is highly important to detect early findings of the disease so that treatment can be started as early as possible. The high cost, poor accessibility and long waiting time for Magnetic Resonanace Imaging (MRI) as compared to Ultrasound (USG) results in delayed pick up of early RA findings. Aim: To compare the radiological parameters of wrist and hand by USG and MRI in clinically diagnosed patients of early RA. Materials and methods: A cross-sectional study was conducted from January 2020 to December 2020 in the Department of Radiology, Indira Gandhi Medical College and Hospital, Shimla. A total of 25 diagnosed patients of early RA were enrolled in the study. USG and MRI were used to evaluate distal Distal Radioulnar (RU), Radiocarpal (RC), Ulnocarpal (UC), Metacarpo phalangeal (MCP) and other hand joints with clinical symptoms. The following parameters were assessed on both MRI and USG: Joint space, Joint effusion, Synovitis, Tenosynovitis, Bone erosions. Bone marrow oedema was assessed only on MRI. The categorical variables of the two groups were compared using the chi-square test. Results: The mean age of the study group was 44.96±11.58 years. There were 18 female and 7 male patients with preponderance of female patients. MRI was better than USG in picking up findings of joint space narrowing, synovial thickening, synovial vascularity and bone erosions with p-value of <0.001, which was statistically significant. For Tenosynovitis, USG and MRI were equally good with p-value of <0.001 which was statistically significant. Joint effusion was diagnosed in more number of joints 26 (6.5%) on USG as compared to 15 (3.5%) on MRI, however, the p-value was 0.078 suggesting that it was statistically insignificant. Bone marrow oedema was detected only on MRI. Conclusion: USG can be used to detect changes of early Rheumatoid Arthritis especially joint effusion and tenosynovitis when MRI is contraindicated/not available/waiting period for MRI is too long.
Bilateral Duplication of Renal Artery in a Cadaver and Its Clinical Implications: A Case Report
Authors: Pawar Pranav Ramesh , Anturlikar Vavishali , Shivapuje Shivam Deepak , Shah Smit Nikunj
Published: April 2023

In normal adult renal system, the renal artery originates from the abdominal aorta at the level of the lower border of L1 vertebrae, just below the origin of the superior mesenteric artery, one on each side. In 15-30% of the population, rare variation in origin and distribution pattern of renal artery can be seen. These variations may be attributed to anomalies in the development of the vascular system. These anomalies lead to the emergence of accessory or multiple renal arteries, causing significant variations in normal anatomical pattern. The aim of present study was to report the presence of double renal arteries on both sides, which has about 10% occurrence amongst all renal artery variations. Most commonly, double arteries are found unilaterally in approximately 30% of cases. Also, in the present case, the renal system was perfused by additional prehilar branches and polar arteries arising from either of the renal arteries. Hence, it is a rare entity. The occurrence of such variation in the vasculature of renal arteries has significant clinical implications. The knowledge of presence of aberrant or multiple renal arteries is significant for urologists, physicians, radiologists and surgeons, while performing surgeries related to kidneys, adrenal glands and associated structures.
Evaluation of Carotid Arteries in Stroke Patients using Colour Doppler Sonography: A Cross-sectional Study
Authors: Vijaywargiya Rakesh , Bhandari Gaurav , Lodhi Vasudev , Tanwani Aksha
Published: April 2023

Introduction: Cerebral ischaemic stroke is a neurological condition that can be fatal and debilitating and is one of the leading causes of morbidity and mortality. The major benefit of sonography is its capacity to describe plaque and identify plaques with increased risk of embolisation, in addition, to evaluate the degree of stenosis. Aim: To diagnose and characterise the plaque morphology in extracranial portion of carotid arteries using colour Doppler sonography in patients with stroke. Materials and Methods: A time-bound, hospital-based cross-sectional study was conducted in the Department of Radiodiagnosis, MGM Medical College and MY Hospital, Indore, Madhya Pradesh, India from August 2021 to July 2022. There were 80 stroke patients in the study. Risk factors like smoking, diabetes, hypertension, and family history were recorded. B- mode ultrasonography was used to assess carotid arteries and various Doppler parameters like Peak Systolic Velocity (PSV). Plaque characteristics and morphology like smooth margin, irregular margin, ulceration and haemorrhage were evaluated. Statistical parameters such as Student’s t-test were used for association between ICA PSV and ICA/CCA PSV with degree of stenosis. Results: Hypertension was the most common risk factor 57 (71.1%). A total of 54 (67%) stroke patients were found to have plaque in their carotid vasculature. A total of 21 (38.8%) of patients had type-3 plaque followed by type-1 plaque 14 (25.9%). Out of 67% of patients who had plaque, majority of patients 38 (47.5%) had <50% stenosis and 16 (29.6%) of patients had significant stenosis (>50%). Conclusion: It was shown that carotid Doppler ultrasonography can be used as a screening tool for patients, who have risk factors for stroke to find asymptomatic carotid disease.
Assessing Resilience among Medical Teachers: A Necessary Step in Building More Equipped Medical Teaching: A Cross-sectional Study
Authors: Karmakar Bankim Chandra , Dasgupta Debdeep , Sinhababu Sunanda , Mukherjee Suranjana Sur
Published: April 2023

Introduction: Resilience among medical teachers is not only a subject of academic inquiry but also a growing body of literature. It encompasses perceiving the way of adaption of strategies in times of adversity or change as well as enable people carry on their jobs and lives. Aim: To assess overall scores and scores of seven domains of resilience-assessment like vision, determination, interaction, relationships, problem solving, organisation and self-confidence. Materials and Methods: This observational cross-sectional study was carried out in the Department of Physiology BSMC&H, Bankura on 60 medical educators for the period starting in April, 2021 and ending in February, 2022. The Resilience Assessment Questionnaire (RAQ) in Google form was sent to the subjects through email for participating in the study. The responses of RAQ were recorded and analysed by Microsoft excel- 2019. Results were represented in the form of descriptive statistics. Results: The data was obtained from 60 medical educators of the institute having mean age 49.63 years and comprising of both sexes with at least 10 years of experience of teaching. With respect to Overall scores, 83.3% of the subjects (n=50) had scores between 35-140 (low score) while only 16.7% (n=10) were found to be pretty resilient. Regarding determination scores 51.7% (n=31) subjects had scores between 5-15 (low level of determination and 33.3% (n=20) had considerable determination (score 16-20) while only 15% (n=9) were determined persons (score 21-25). A total of 50% (n=30) subjects were not very good in Problems solving score, 28.4% (n=17) liked and succeeded in solving problems. About 30% (n=18) scored 16-25 and had considerable self-confidence whereas 5% (n=3) scored poorly. In less than 15% of the subjects, the Score of Vision (n=10), Interaction (n=6), Relationship (n=14) and Organisational (n=5) skill were found to be in the higher range (score 21-25) whereas 85% (n=50, 54, 46 & 55 respectively) subjects scored poorly (score 5-20) in these categories. Conclusion: In the present study, resilience of ≥50% participants were found to be at a lower level. It draws attention of medical educators to reconsider the multidimensional factors that influenced their resilience. It may be proposed that brave decisions and actions aiming to improve resilience must be made by medical educators to help making medical students responsible doctors of tomorrow.
Analysis of Technical Efficiency of Rice Farmers under Farmer Producer Organisation (FPO) in Guntur District of Andhra Pradesh
Authors: Sanghamitra G. , Kumar K. Nirmal Ravi
Published: April 2023

The study investigated the Technical efficiency (TE) of rice farmers under Farmer Producer Organisation (FPO) in Guntur District of Andhra Pradesh using Data Envelopment Analysis (DEA) and Stochastic Frontier Analysis (SFA) from a sample size of 40 farmers. The results from DEA and SFA revealed that the mean TE of rice farmers was 98.7 per cent and 86 per cent respectively. The mean TE from DEA is indicating that they can reduce their input by 1.3 per cent to produce the same level of output and SFA revealed that the coefficients of seed (0.7543), urea (0.877), MOP (0.979) and machine hours (0.877) were positive and highly significant, implying that these inputs are productive enough whereas DAP (0.877), PPC (0.765) and human labour (0.988) were positive but non-significant implying that they are comparatively less productive. From the results of DEA and SFA, the mean efficiency of rice farmers through DEA (0.98) was more than SFA (0.86). The results from Garrett ranking revealed that price versatility, high input prices, lack of proper labour supply, lack of adequate capital and storage facilities etc., are the major constraints faced by rice farmers under FPO in Guntur district and they need to be strengthened.
Examining the Factors that Influence the School Leadership Practices in Senior High School Teachers at the Tano North District, Ghana
Authors: Nifaa-Ib Tuokpe Gilbert , Attia Isaac
Published: April 2023

Leadership practices of school heads can positively or negatively affect learning outcomes and ultimately the educational goals of the country. Understanding the influence factors of leadership practices is fundamental to school improvement. The main aim of this article was to present factors that influence the leadership practices of heads of schools. Using public senior high school teachers and heads in the Tano North District in the Ahafo Region of Ghana as the target population, 158 of them including 154 teachers and 4 headmasters from all 4 schools in the District were selected through a multi-stage sampling technique. Data were collected using the authors’ self-developed questionnaire after pilot-testing for its refinement.The content and construct validity of the instruments were reviewed and validated by experts in the authors' institutions. Descriptive statistics (frequency and percentage) were used to analyse the data. The study found that communication, intelligence and inclusive approach are factors that influence school leadership practices. Based on the findings of the study, the researchers recommend the Ghana Education Service through the Ministry of Education organize periodic leadership training for heads of senior high schools to equip them with appropriate and innovative leadership practices.
The Efficacy of Saline Nasal Irrigation in Chronic Rhinosinusitis: A Single Centre Experience
Authors: Haque Md. Sazzadul , Saheeduzzaman  , Rahman Mushfiqur , Rahman Atiur
Published: April 2023

Background: Nasal irrigation (also known as nasal douche, wash or lavage) is a procedure that rinses the nasal cavity with water or isotonic or hypertonic saline solutions. Nasal irrigation with saline (salt water) is common in modern and traditional therapy regimes. Delivered by bottle, spray, pump or nebuliser, the topical use of saline has been included as a supplement to most treatment protocols.

Aim of the Study: The study aimed to evaluate the Efficacy of Saline Nasal Irrigation in Chronic Rhinosinusitis in a tertiary care hospital.

Methods: This prospective observational study was conducted at the ENT outpatient department of Ent, Monno Medical College and Hospital, Manikganj, Bangladesh from January 2022 to December 2022.

Results: Most patients (76%) strictly used SNI, while a smaller proportion (24%) only occasionally used it. After treatment with SNI, 46% of cases showed improvement in symptoms, while 54% showed no improvement. Statistical analysis revealed a significant difference in efficacy between improvement and no improvement (p<0.05). These findings suggest that SNI may effectively manage nasal congestion symptoms, particularly when used consistently.

Conclusion: Chronic rhinosinusitis significantly negatively impacts the healthcare and economy of not only the patients but also society. Saline nasal irrigation is a practical yet easy therapy method for alleviating the symptoms of chronic rhinosinusitis and improving the quality of life in these chronic sufferers.
Fixed Point Results in Complete Random Cone Metric Spaces Over Banach Algebra
Authors: Manoj K. , Hussain R. Jahir
Published: April 2023

We define fixed point results in Random cone metric space (RCMS) over Banach algebra. Also we giverelated corollaries and illustrate the examples.
Effect of Textile Effluent on Seed Germination and Early Growth of Wheat (Triticum aestivum L.) and Mustard (Brassica juncea L.)
Authors: Kurmi Keshav Prasad , Singh Satyavir , Tailor S. P. , Chaudhary Amit Kumar
Published: April 2023

An experiment was conducted during rabi season in the year 2021-22 at Soil Science & Agricultural Chemistry, Laboratory of Sangam University, Bhilwara (Rajasthan) India, to evaluate the “Effect of textile effluent on seed germination and early growth of Wheat (Triticum aestivum L.) and Mustard (Brassica juncea L.): A case study” consist of four (Treated industrial effluent) treatment  (T1) freshwater, (T2) 25% effluent+75% fresh water, (T3) 50% effluent+50 % fresh water, (T4) 75 % effluent+25% freshwater to determine the effects of textile effluent’s toxicity on wheat and mustard seed germination rates and early growth as well as growth factors like plumule and radicle length. With higher effluent concentrations, the proportion of seed germination and seedling growth gradually decreased. Germination percentage, plumule and radicle length of seedlings were lowest in the treatment T4 (75% effluent + 25% fresh water) and highest in treatment T2 (25% effluent + 75 fresh water) treatment.
“You’ve Got Mail”—Receiving Bad News Through a Patient Portal
Authors: Bellizzi Keith M.
Published: April 2023

This Viewpoint discusses the impersonalization of delivering bad news to patients through a patient portal rather than in person.