bluuebunny/crossref_metadata_2025 huggingface dataset:
Re-Imagining Leadership Roles beyond the Shadow of Bureaucracy
Authors: Ehrich Lisa Catherine , English Fenwick Walter
Published: March 2024

The aim of this conceptual paper is to revisit the relationship between leadership and bureaucracy. The dominant and unquestioned way of thinking about leadership is to equate it as an undertaking exercised by leaders, those officers who occupy hierarchical positions in organizations. For example, senior leadership and middle leadership in schools are often associated with formal hierarchical roles played by senior and middle leaders. However, it can be argued that this perspective is problematic, not only because it is leader-centric but also due to its limitations in explaining the phenomenon of leadership. In order to understand the relationship between leadership and bureaucracy and leadership outside of bureaucracy, the paper reviews some of the extant literature in the field, including a brief history of bureaucracy, its pervasiveness in educational institutions, and current neo-liberal policies and reforms that function effectively within bureaucratic structures. An important contribution of the paper is a synoptic conceptual model that brings together three worldviews or archetypes pertaining to bureaucracy. These are a hard-edged view (system first, people second), a soft-edged view (people first, system second) and a third worldview (issue first, people second, system third). The third worldview signals a departure from the first two archetypes as it is an illustration of leadership outside the confines of bureaucracy.
New High-Rate Timestamp Management with Real-Time Configurable Virtual Delay and Dead Time for FPGA-Based Time-to-Digital Converters
Authors: Garzetti Fabio , Bonanno Gabriele , Lusardi Nicola , Ronconi Enrico , Costa Andrea , Geraci Angelo
Published: March 2024

Modern applications require the ability to measure time events with high resolution, a full-scale range, and multiple input channels. Time-to-Digital Converters (TDCs) are a popular option to convert time intervals into timestamps. To reduce the time-to-market and Non-Recurring Engineering (NRE) costs, a Field-Programmable Gate Array (FPGA) implementation has been chosen. The high number of requested bits and channels, however, gives rise to routing congestion issues when routed in a parallel manner. In this paper, we will propose and analyze a novel solution, the Belt-Bus (BB), which involves a parallel-to-serial conversion of the timestamp stream coming from the TDC while maintaining chronological order and a sufficient high rate, and flagging the presence of timestamp overflow. Moreover, two new useful features are added. The first is a “Virtual Delay” to compensate for offsets due to cable length and FPGA routing path mismatch. The second is a “Virtual Dead-Time” to filter out unforeseen events. Finally, the BB was tested on a Xilinx 28 nm 7-Series Kintex-7 325T FPGA, achieving an overall data rate of 199.9 Msps with very limited resource usage (i.e., lower than a total of 4.5%), consuming only 480 mW in a 16-channel implementation.
Evaluation of Fatigue in Older Drivers Using a Multimodal Medical Sensor and Driving Simulator
Authors: Yoshida Yutaka , Kowata Kohei , Abe Ryotaro , Yuda Emi
Published: March 2024

In recent years, the spread of wearable medical sensors has made it possible to easily measure biological signals such as pulse rate and body acceleration (BA), and from these biological signals, it is possible to evaluate the degree of biological stress and autonomic nervous activity in daily life. Accumulated fatigue due to all-day work and lack of sleep is thought to be a contributing factor to distracted driving, and technology to estimate fatigue from biological signals during driving is desired. In this study, we investigated fatigue evaluation during a driving simulator (DS) using biological information on seven older subjects. A DS experiment was performed in the morning and afternoon, and no significant differences were observed in the change over time of heart rate variability and skin temperature. On the other hand, in the afternoon DS, changes in arousal and body movements were observed based on BA calculated from the three-axis acceleration sensor and fingertip reaction time in a psychomotor vigilance test. It is suggested that by combining biological information, it may be possible to evaluate the degree of fatigue from the presence or absence of arousal and changes in body movements while driving.
Federated Learning Incentive Mechanism Setting in UAV-Assisted Space–Terrestrial Integration Networks
Authors: Zhu Chun , Sui Mengqi , Zhao Haitao , Chen Keqi , Zhang Tianyu , Bao Chongyu
Published: March 2024

The UAV-assisted space–terrestrial integrated network provides extensive coverage and high flexibility in communication services. UAVs and ground terminals collaborate to train models and provide services. In order to protect data privacy, federated learning is widely used. However, the participation of UAVs and ground terminals is not gratuitous, and reasonable incentives for federated learning need to be set up to encourage their participation. To address the above issues, this paper proposes a federated reliable incentive mechanism based on hierarchical reinforcement learning. The mechanism allocates inter-round incentives at the upper level to ensure the maximisation of the server’s utility, and performs inter-client incentive allocation at the lower level to ensure the minimisation of each round’s latency. The reasonable incentive allocation enables the central server to achieve higher model training accuracy under the limited incentive budget, which reduces the cost of model training. At the same time, an attack detection mechanism is implemented to identify malicious clients participating in federated learning, preventing their involvement in aggregation and revoking their incentives. This better ensures the security of model training. Finally, we conducted experiments on Fmnist, and the results indicate that this method effectively improves the accuracy and security of model training.
A Novel Authentication Scheme Based on Verifiable Credentials Using Digital Identity in the Context of Web 3.0
Authors: Nita Stefania Loredana , Mihailescu Marius Iulian
Published: March 2024

This paper explores the concept of digital identity in the evolving landscape of Web 3.0, focusing on the development and implications of a novel authentication scheme using verifiable credentials. The background sets the stage by placing digital identity within the broad context of Web 3.0′s decentralized, blockchain-based internet, highlighting the transition from earlier web paradigms. The methods section outlines the theoretical framework and technologies employed, such as blockchain, smart contracts, and cryptographic algorithms. The results summarize the main findings, including the proposed authentication scheme’s ability to enhance user control, security, and privacy in digital interactions. Finally, the conclusions discuss the broader implications of this scheme for future online transactions and digital identity management, emphasizing the shift towards self-sovereignty and reduced reliance on centralized authorities.
Noncontact Automatic Water-Level Assessment and Prediction in an Urban Water Stream Channel of a Volcanic Island Using Deep Learning
Authors: Mendonça Fábio , Mostafa Sheikh Shanawaz , Morgado-Dias Fernando , Azevedo Joaquim Amândio , Ravelo-García Antonio G. , Navarro-Mesa Juan L.
Published: March 2024

Traditional methods for water-level measurement usually employ permanent structures, such as a scale built into the water system, which is costly and laborious and can wash away with water. This research proposes a low-cost, automatic water-level estimator that can appraise the level without disturbing water flow or affecting the environment. The estimator was developed for urban areas of a volcanic island water channel, using machine learning to evaluate images captured by a low-cost remote monitoring system. For this purpose, images from over one year were collected. For better performance, captured images were processed by converting them to a proposed color space, named HLE, composed of hue, lightness, and edge. Multiple residual neural network architectures were examined. The best-performing model was ResNeXt, which achieved a mean absolute error of 1.14 cm using squeeze and excitation and data augmentation. An explainability analysis was carried out for transparency and a visual explanation. In addition, models were developed to predict water levels. Three models successfully forecasted the subsequent water levels for 10, 60, and 120 min, with mean absolute errors of 1.76 cm, 2.09 cm, and 2.34 cm, respectively. The models could follow slow and fast transitions, leading to a potential flooding risk-assessment mechanism.
Yeast Biotechnology 6.0
Authors: Willaert Ronnie G.
Published: March 2024

This Special Issue continues the “Yeast Biotechnology” Special Issue series of the MDPI journal Fermentation [...]
Assessing the Technical and Economic Viability of Galvanizing Snow Crab (Chionoecetes opilio) Traps
Authors: Brown Pete , Araya-Schmidt Tomas , Bungay Terry , Winger Paul D.
Published: March 2024

Commercial harvesting of snow crabs (Chionoecetes opilio) began in Newfoundland and Labrador, Canada, in 1967. Today, the fishery consists of 2188 active fishing licenses and has grown into the province’s most economically valuable fishery. Snow crabs are captured using conical traps consisting of a mild carbon steel frame, hard plastic entry funnel and a jacket of polyethylene netting. The frames of these traps corrode over time, which is expedited by being deployed in marine environments and stored on land near the ocean when not in use. As a result, there is interest within the community to increase the longevity of crab traps. One solution is to galvanize the steel frames prior to installing the funnel and netting. However, before harvesters transition to galvanized traps, two questions must be answered. Will the use of galvanized steel negatively impact catch rates? Will the life cycle of a crab trap be extended sufficiently to justify the additional cost of galvanizing? This study employed a generalized linear mixed model to evaluate the catch of legal-sized male crabs (CPUE) during the commercial fishery as a function of three trap frame treatments (old traditional, new traditional and new galvanized). We also assessed the economic viability of galvanizing trap frames by evaluating the life cycle cost (LCC) of traditional and galvanized traps to the harvester. The LCC was calculated over a range of inflation (0–6%) and discount (3–20%) rates. Our results found no significant difference in CPUE between new traps (traditional vs. galvanized) and concluded that except during instances of very high discount rates (12.9–19.9%), it is economically favourable to galvanize crab trap frames.
Impact of the COVID-19 Pandemic on Changes in Consumer Purchasing Behavior in the Food Market with a Focus on Meat and Meat Products—A Comprehensive Literature Review
Authors: Żurek Jagoda , Rudy Mariusz
Published: March 2024

The coronavirus has wreaked havoc on the global economy before the eyes of the entire world. Due to evolving consumer needs and expectations during the pandemic, the supply and demand for various goods and services varied from the pre-COVID-19 period. This article aims to understand the changes in purchasing and food choices, focusing particularly on meat and meat products, made by consumers and households in response to the crisis caused by the COVID-19 pandemic. The study also indicates the impact directions of these changes and assesses the magnitude of the contribution of various determinants that influenced them. The literature review from 2020 to 2023 was conducted using Scopus and the Web of Science scientific databases. The study identified sociodemographic and individual factors as the main determinants influencing consumers’ purchasing or eating behavior. Positive shifts (e.g., implementing strategies to better manage food at home through activities like creating shopping lists, the average increase in consumer spending during store visits, and decrease in visit frequencies) or negative changes (e.g., shortages of food products in stores due to consumer panic buying, unusually high demand resulting from stockpiling, purchasing fewer fresh products, increased consumption of unhealthy foods and snacking, among other factors) during isolation were influenced by various individual factors (e.g., motivation, mental state) or sociodemographic factors (e.g., gender, age, income level, education). While individual factors had a greater impact on changes in consumer behavior in the early stages of the COVID-19 pandemic, socio-demographic factors became more important as the pandemic progressed.
Metal Content, Fatty Acid and Vitamins in Commercially Available Canned Fish on the Bulgarian Market: Benefit–Risk Ratio Intake
Authors: Peycheva Katya , Panayotova Veselina , Hristova Tatyana , Merdzhanova Albena , Dobreva Diana , Stoycheva Tonika , Stancheva Rositsa , Licata Patrizia , Fazio Francesco
Published: March 2024

Today, the distribution and consumption of canned products have become widespread due to the convenience of using processed fish products. This study aims to evaluate elements of toxicological concern and essential elements (Cd, Al, Cu, Cr, Mn, Fe, Pb, Ni, and Zn), the fatty acid composition, and the fat-soluble vitamin and antioxidant pigment contents of various canned fish products purchased on the Bulgarian market. The estimated weekly intake and human health benefit–risk ratio based on metal elements and n-3 LC-PUFA contents in canned fish products were assessed. The contents of the analyzed elements in the canned samples were found to be below the limits set by various health organizations. Al was detected in only one sample. The profile of fatty acids showed that the canned fish had high PUFA/SFA ratios, EPA + DHA contents and low SFA, AI and TI values. The analyzed canned fish contained significant contents of fat-soluble vitamins. The Atlantic bonito in a jar sample was characterized by a high percentage of vitamin A (26.7% RDI) and vitamin D3 (142% RDI) per 100 g portion. The calculated EWI value shows that the consumption of canned fish products did not present any risk. The benefit–risk ratio indicates that the canned fish species are safe for human consumption, except for one sample regarding Cr.
Phytochemical, Nutritional and Mineral Content of Four Edible Flowers
Authors: Marchioni Ilaria , Gabriele Morena , Carmassi Giulia , Ruffoni Barbara , Pistelli Luisa , Pistelli Laura , Najar Basma
Published: March 2024

The growing interest in functional foods is driven by the exploration of new foods with positive health effects. Pleasant sensory features are essential for consumer acceptance. In this work, we investigated the composition of the bioactive compounds, antioxidant activity, and aroma profiles of four edible flowers: Cucurbita moschata Duchesne, Dianthus chinensis L., Fuchsia regia (Vand. ex Vell.) Munz., and Viola cornuta L. For the first time, we quantified the water-soluble group of B vitamins. Significant variations in the content of soluble sugars, vitamins, and secondary metabolites were observed. V. cornuta showed the highest concentration of vitamin C and carotenoids, while C. moschata had the highest content of vitamin B and flavonoids. F. regia stood out for its exceptionally high content of total phenolics, while D. chinensis surpassed the other flowers in soluble sugar content. The aroma profile analysis revealed a diverse array of volatile organic compounds, with each species having its own unique composition. C. moschata was characterized by p-dimethoxybenzene and D. chinensis by non-terpene compounds; F. regia displayed high amounts of decanal and nonanal, while V. cornuta was rich in myrcene and α-farnesene. These findings provide valuable insights into the secondary metabolites and aroma profiles of these flowers, enhancing our understanding of their bioactive compounds and potential health benefits.
Consumer Insights to Eco-Design a Hot Sauce: Understanding Household Use for Product Optimization through Focus Groups and a Home-Use-Test Study
Authors: Torán-Pereg Paula , Romeo-Arroyo Elena , Novoa Stéfani , Pardo Guillermo , Vázquez-Araújo Laura
Published: March 2024

Promoting sustainable choices requires making food with proper environmental performance readily available to consumers, but these products must be appealing to ensure market success. The aim of the present study was to investigate the acceptability and perception of an eco-designed product using a home-use-test approach to identify its desired extrinsic features and to better understand how consumers would use the product in a real consumption context. First, three focus groups were conducted to identify the key perceived aspects of the product. A consumer survey was designed with the information gathered from the focus groups, and a home-use-test was then performed (n = 207). Results showed high acceptance of the product, as well as its potential corrections, e.g., to thicken the texture of the sauce. A total of 64% of consumers expressed their willingness to switch from a well-known brand to the new developed product, and this hypothetical shift could lead up to a 58% reduction in greenhouse gas emissions associated with the product use. Understanding consumer expectations at every design stage helps the development of market-viable and sustainable products, and the present research proposes an interesting methodology that can be effectively applied during the final stages of eco-designed food development.
Modulatory Effects of Lactarius hatsudake on Obesity and Gut Microbiota in High-Fat Diet-Fed C57BL/6 Mice
Authors: Zhu Hanyu , Hou Tao
Published: March 2024

Lactarius hatsudake (LH), a great wild endemic fungus, contains rich nutritional components with medicinal properties. The effects of LH on body weight, liver weight, liver injury, blood lipids, and gut microbiota in C57BL/6 mice fed a high-fat diet (HFD) for 8 weeks was examined in this research. Though there was no clear impact on weight loss, the findings indicate that LH treatment effectively decreased liver damage caused by HFD, as well as lowered serum total cholesterol, triacylglycerol, and low-density lipoprotein cholesterol levels. Additionally, it positively influenced gut microbiota to resemble that of mice on a normal diet. In HFD-fed mice, LH markedly boosted the levels of Parabacteroides, unclassified Muribaculaceae, Oscillibacter, and unclassified Oscillospiraceae, while reducing the abundance of Lachnospiraceae NK4A136 group and Erysipelatoclostridium, as well as the ratio of Firmicutes to Bacteroidetes. Further analysis of correlation indicate a possible connection between obesity and gut microbiota. Obesity-related indices show a positive association with unclassified Eubacterium coprostanoligenes group, Blautia, and Erysipelatoclostridium, while displaying a negative correlation with unclassified Muribaculaceae, unclassified Clostridia vadinBB60 group, Helicobacter, Oscillibacter, unclassified Ruminococcaceae, Parabacteroides, and unclassified Oscillospiraceae. The results suggest that LH can help combat obesity and may have the potential to be utilized as a functional food.
Association of Serum Calcium Levels of Preterm Neonates at Birth with Calcium Intake from Foods and Supplements by Bedridden Women during Pregnancy
Authors: Gioxari Aristea , Papandreou Panos , Daskalou Efstratia , Kaliora Andriana C. , Skouroliakou Maria
Published: March 2024

Bone calcium turnover is aggravated in pregnant women recommended to bed rest. In the present cross-sectional study, we aimed to clarify whether preterm neonates would benefit from calcium supplementation during pregnancy. Forty-two mothers (37.5 ± 6.7 years), recommended bed rest at home, and 42 preterm neonates (24–37 weeks gestational age) were enrolled. Neonates’ serum calcium was quantified at birth. Mothers’ calcium intake from foods and supplements during pregnancy was assessed. Serum 25-OH-D was measured in both mothers and neonates at birth. Results showed that mothers’ calcium intake from foods was significantly lower than the recommended daily reference value (p < 0.001), while total calcium intake including supplements was close to the calcium reference value of 1000 mg/day (p = 0.648). Neonates’ serum calcium concentration was significantly higher in mothers receiving calcium supplementation during pregnancy compared to mothers who did not (p < 0.001). A significant association between neonates’ serum calcium levels and mothers’ calcium supplementation was evident, even when adjusted to mothers’ age, pre-pregnancy BMI, gestational age, and neonates’ birth weight (beta = +0.460, p = 0.025). A statistically significant correlation between neonates’ and mothers’ serum 25-OH-D levels was found (r = 0.891, p < 0.001). In conclusion, calcium status in preterm neonates, born by bedridden women, could be enhanced after calcium supplementation during gestation.
Unraveling the Dynamics of Intellectual Capital, Firm Performance, and the Influential Moderators—BIG4 Auditors and Group Affiliation
Authors: Mohapatra Swati , Pattanayak Jamini Kanta
Published: March 2024

The importance of intellectual capital (IC) in past decades unfolds several dimensions of firm performance (FP). Still, the contradictory and inconclusive relationship between IC and FP in the literature motivates the researchers to explore further and understand the empirical connection using both linear and curvilinear approaches. Using the fixed-effect panel regression models on a sample of 795 non-financial firms of India from the financial years 2004–2005 to 2020–2021, this study reveals that, undoubtedly, the IC enhances the FP up to a certain threshold, and with any marginal investment, IC reduces the FP by forming the inverted U-shaped curve. Interestingly, the presence of BIG4 auditors in Indian firms helps to increase the FP with the help of IC, even for the group-affiliated firms. Thus, this study aligns with both value creation and cost concern perspectives and implies that management and regulatory bodies may adopt a balanced approach while enhancing the FP through IC, as the result suggests that investment in IC will not endlessly improve the FP in the Indian context.
Wetland Classification, Attribute Accuracy, and Scale
Authors: Carlson Kate , Buttenfield Barbara P. , Qiang Yi
Published: March 2024

Quantification of all types of uncertainty helps to establish reliability in any analysis. This research focuses on uncertainty in two attribute levels of wetland classification and creates visualization tools to guide analysis of spatial uncertainty patterns over several scales. A novel variant of confusion matrix analysis compares the Cowardin and Hydrogeomorphic wetland classification systems, identifying areas and types of misclassification for binary and multivariate categories. The specific focus on uncertainty in the paper refers to categorical consistency, that is, agreement between the two classification systems, rather than comparing observed data to ground truth. Consistency is quantified using confusion matrix analysis. Aggregation across progressive focal windows transforms the confusion matrix into a multiscale data pyramid for quick determination of where attribute uncertainty is highly variant, and at what spatial resolutions classification inconsistencies emerge. The focal pyramids summarize precision, recall, and F1 scores to visualize classification differences across spatial scales. Findings show that the F1 scores appear most informative on agreement about wetlands misclassification at both coarse and fine attribute scales. The pyramid organizes multi-scale uncertainty in a single unified framework and can be “sliced” to view individual focal levels of attribute consistency. Results demonstrate how the confusion matrix can be used to quantify the percentage of a study area in which inconsistencies occur reflecting wetland presence and type. The research provides confusion metrics and display tools to focus attention on specific areas of large data sets where attribute uncertainty patterns may be complex, thus reducing land managers’ workloads by highlighting areas of uncertainty where field checking might be appropriate, and improving analytics by providing visualization tools to quickly see where such areas occur.
Hydrogenolysis of Glycerol over NiCeZr Catalyst Modified with Mg, Cu, and Sn at the Surface Level
Authors: Vera-Hincapie Norberto , Iriarte-Velasco Unai , Ayastuy Jose Luis , Gutiérrez-Ortiz Miguel Ángel
Published: March 2024

Biomass valorization is an essential strategy for converting organic resources into valuable energy and chemicals, contributing to the circular economy, and reducing carbon footprints. Glycerol, a byproduct of biodiesel production, can be used as a feedstock for a variety of high-value products and can contribute to reducing the carbon footprint. This study examines the impact of surface-level modifications of Mg, Cu, and Sn on Ni-Ce-Zr catalysts for the hydrogenolysis of glycerol, with in situ generated hydrogen. The aim of this approach is to enhance the efficiency and sustainability of the biomass valorization process. However, the surface modification resulted in a decrease in the global conversion of glycerol due to the reduced availability of metal sites. The study found that valuable products, such as H2 and CH4 in the gas phase, and 1,2-PG in the liquid phase, were obtained. The majority of the liquid fraction was observed, particularly for Cu- and Sn-doped catalysts, which was attributed to their increased acidity. The primary selectivity was towards the cleavage of the C–O bond. Post-reaction characterizations revealed that the primary causes of deactivation was leaching, which was reduced by the inclusion of Cu and Sn. These findings demonstrate the potential of Cu- and Sn-modified Ni-Ce-Zr catalysts to provide a sustainable pathway for converting glycerol into value-added chemicals.
Association of a Global Invasive Pest Spodoptera frugiperda (Lepidoptera: Noctuidae) with Local Parasitoids: Prospects for a New Approach in Selecting Biological Control Agents
Authors: Nurkomar Ihsan , Putra Ichsan Luqmana Indra , Buchori Damayanti , Setiawan Fajar
Published: March 2024

Spodopotera frugiperda is a worldwide invasive pest that has caused significant economic damage. According to the classical biological control approach, natural enemies that can control invasive pests come from the same area of origin as the pests that have experienced coadaptation processes. However, the new association’s approach suggests that local natural enemies are equally capable of controlling invasive pests. Due to the lack of data on the association of S. frugiperda and local natural enemies, research was conducted through a rapid survey to study the diversity of parasitoids associated with S. frugiperda. The results showed 15 parasitoid species associated with S. frugiperda. Four egg parasitoids, eight larval parasitoids, and three larval–pupal parasitoids were found to be associated with S. frugiperda for three years after it was first discovered in Indonesia. Eleven of them are new reports of parasitoids associated with S. frugiperda in Indonesia. A new association was found between S. frugiperda and twelve parasitoid species, consisting of three egg parasitoids (Platygasteridaesp.01, Platygasteridaesp.02, and Telenomus remus), six larval parasitoids (Apanteles sp., Microplitis sp., Campoletis sp., Coccygidium sp., Eupelmus sp., and Stenobracon sp.), and three larval–pupal parasitoids (Brachymeria lasus, B. femorata, and Charops sp.). Telenomus remus is the most dominant parasitoid, with a higher abundance and parasitism rate. The result suggests another method for selecting biological control using the new association approach since local natural enemies can foster quick adaptation to invasive pests.
Examining Innovative Technologies: Nano-Chelated Fertilizers for Management of Wheat Aphid (Schizaphis graminum Rondani)
Authors: Chamani Masoud , Naseri Bahram , Rafiee-Dastjerdi Hooshang , Emaratpardaz Javid , Farshbaf Pourabad Reza , Chenari Bouket Ali , Oszako Tomasz , Belbahri Lassaad
Published: March 2024

The use of nanofertilizers has both advantages and concerns. One benefit is that nano-fertilizers can enhance plant resistance against insect pests, making them a valuable strategy in integrated pest management (IPM). This study focused on the effect of wheat leaves treated with nano-chelated fertilizers and nitrogen (N) fertilizer on the wheat aphid (Schizaphis graminum Rondani), a harmful pest of wheat plants that transmits dangerous viruses. The nano-Cu treatment showed the longest pre-adult longevity. Additionally, the nano-Cu treatment resulted in the lowest adult longevity, fecundity, nymphoposition day number, intrinsic rate of population growth (r), finite rate of population increase (λ), and net reproductive rate (R0) and gross reproductive rate (GRR). Also, nano-Cu treatment led to the highest amount of (T). The N treatment led to the highest levels of fecundity, nymphoposition days, r, λ, and R0. Nano-Fe and nano-Zn demonstrated fewer negative effects on S. graminum life table parameters than nano-Cu. Our results indicate that N treatment yielded numerous advantageous effects on the wheat aphid while simultaneously impeding the efficacy of the aphid control program. Conversely, nano-Cu treatment exhibited a detrimental influence on various parameters of the aphid’s life table, resulting in a reduction in the pest’s fitness. Consequently, the integration of nano-Cu should be seriously considered as a viable option in the IPM of the wheat aphid.
Does Portal Hypertension Increase the Risk of Helicobacter pylori Infection and Pre-Malignant Gastric Lesions?
Authors: Gaspar Rui , Cardoso Pedro , Ribeiro Tiago , Silva Marco , Macedo Guilherme
Published: March 2024

Background and Aims: The presence of portal hypertension in cirrhotic patients is a major prognostic factor associated with the development of severe complications and increased mortality. The gold standard for diagnosing portal hypertension is the hepatic venous pressure gradient. More recently, spleen stiffness has emerged as a new and non-invasive diagnostic tool, and has already been included in the last Baveno VII guidelines. The exact prevalence of Helicobacter pylori infection, pre-malignant lesions and their relation to portal hypertension have never been described. The aim of our study was to evaluate the relationship between the presence of portal hypertension assessed via liver and spleen elastography and Helicobacter pylori infection and pre-malignant gastric lesions. Methods: An observational study was conducted, including consecutive patients admitted from December 2020 to December 2022. All patients underwent upper endoscopy and were also subjected to liver and spleen elastography (using the new probe of 100 Hz) by the same blinded operator in a tertiary center. Results: We included 155 cirrhotic patients, with a mean age of 64.1 years (±8.8), and 81.3% were male. The most common etiology was alcoholic liver disease (72.9%). The median value of liver stiffness measurement was 24.4 kPa [3.1–75.0], and the spleen stiffness measurement was 49.1 kPa [12.8–100.0]. Akin to endoscopic findings, 50.3% presented esophageal varices, 5.2% gastric atrophy, 11.6% gastric metaplasia, and 32.9% portal hypertension gastropathy. Regarding histologic findings, we found that 34.8% presented H. pylori infection, 35.5% gastric atrophy (OLGA 1—58.2%) and 38.7% gastric metaplasia (OLGIM 1—63.3%). Liver stiffness and spleen stiffness measurements were associated with the presence of portal hypertensive gastropathy (p < 0.01), but not with H. pylori infection or pre-malignant gastric lesions. Conclusions: Although present in almost one third of cirrhotic patients, H. pylori infection and pre-malignant gastric lesions are not associated with liver stiffness and spleen stiffness measurements. On the other hand, we found an association between liver stiffness and spleen stiffness measurements and portal hypertensive gastropathy.
Haemophilia and Cancer: A Literature Review
Authors: Zanon Ezio , Porreca Annamaria , Simioni Paolo
Published: March 2024

Background: Opinions in the literature on the impact of cancer on patients with haemophilia are contradictory. There is a lack of data on the clinical presentation and management of cancer in patients with haemophilia (PWH). Methods: Papers were found following a comprehensive search in PubMed, Google Scholar, and Scopus using the terms “cancer” and “haemophilia” without time limits and using the English language as a filter. The references from all the retrieved original articles and reviews were assessed for additional relevant articles. Results: The emergence of malignancies is one of the important causes of morbidity and mortality in PWH. In the past decade, the literature mainly focused on the epidemiology and outcome of blood-borne cancers in the haemophilia patient group, as the incidence of hepatitis B virus (HBV), hepatitis C (HCV), and HIV infection were high among them. However, with the introduction of recombinant clotting factor concentrates (CFCs), physicians now pay attention to non-virus-related malignancies. Bleeding and thrombotic complications are important causes of morbidity and mortality in critically ill patients with cancer; replacement therapy with factor VIII or IX or others should be maintained during antitumour treatment. Conclusion: Overall, managing cancer in patients with haemophilia requires careful evaluation and individualised planning involving a multidisciplinary team of physicians experienced in haematology, oncology, and surgery.
Anatomical and Functional Impacts of Congenital Bilateral Visual Deprivation on the Visual Pathway—A Comprehensive Review
Authors: Czarnek-Chudzik Aleksandra , Toro Mario Damiano , Rejdak Robert , Nowomiejska Katarzyna
Published: March 2024

Neuroplasticity is a complex process that is heightened during time-sensitive periods of pre- and postnatal brain development. It continues, albeit to a lesser extent, throughout adolescence and young adulthood. Congenital visual deprivation is well-known and explored in human-model behavioral research. In this study, we review existing research on neuroadaptations and neuroplasticity of the visual pathway as a result of inherited retinal diseases (IRD), focusing on data concerning congenital bilateral visual deprivation in humans published in PubMed in the past 5 years, including 18 articles. We highlight evidence about the anatomical and behavioral aspects of neuroplasticity as different brain responses to different types of visual deprivation. We also focus on various very interesting aspects of the cross-modal functional reorganization of the visual and auditory cortex as an example of brain plasticity due to combined visual and auditory loss. Our study shows that central nervous system magnetic resonance imaging (MRI) advancements have allowed researchers to report previously elusive anatomical evidence. Patients with a known mechanism of IRD—examined with high magnetic field MRI and functional MRI—have been proven to be adequate models to explore neuroadaptations of the visual pathway due to bilateral, early, and late visual deprivation.
Therapeutic Targets in the Management of Dry Eye Disease Associated with Sjögren’s Syndrome: An Updated Review of Current Insights and Future Perspectives
Authors: Almulhim Abdulmohsen
Published: March 2024

Dry eye disease (DED) is a continuing medical challenge, further worsened in the autoimmune inflammatory hyperactivation milieu of Sjögren’s syndrome (SS) due to disturbances to innate and adaptive immunity with malfunctioning neuro-endocrine control. However, the pathogenetic mechanisms of SS DED are not fully established. This review summarized the available evidence, from systematic reviews, meta-analyses, and randomized clinical trials, for the efficacy and safety of the available ocular therapeutics for the management of SS DED. Relevant studies were obtained from major databases using appropriate keywords. The available largely empirical symptomatic, supportive, and restorative treatments have significant limitations as they do not alter local and systemic disease progression. Topical therapies have expanded to include biologics, surgical approaches, scleral lens fitting, the management of lid margin disease, systemic treatments, nutritional support, and the transplantation of stem cells. They are not curative, as they cannot permanently restore the ocular surface’s homeostasis. These approaches are efficacious in the short term in most studies, with more significant variability in outcome measures among studies in the long term. This review offers an interdisciplinary perspective that enriches our understanding of SS DED. This updated review addresses current knowledge gaps and identifies promising areas for future research to overcome this medical challenge.
Augmented Reality-Assisted Transcanal Endoscopic Ear Surgery for Middle Ear Cholesteatoma
Authors: Tsuchida Keisuke , Takahashi Masahiro , Nakazawa Takara , Kurihara Sho , Yamamoto Kazuhisa , Yamamoto Yutaka , Kojima Hiromi
Published: March 2024

Background: The indications for transcanal endoscopic ear surgery (TEES) for middle ear cholesteatoma have expanded for cases involving mastoid extension. However, TEES is not indicated for all cases with mastoid extension. In addition, predicting the extent of external auditory canal (EAC) removal needed for cholesteatoma resection is not always easy. The purpose of this study was to use augmented reality (AR) to project the lesion onto an intraoperative endoscopic image to predict EAC removal requirements and select an appropriate surgical approach. Methods: In this study, patients showing mastoid extension were operated on using a navigation system with an AR function (Stryker). Results: The results showed that some cases with lesions slightly extending into the antrum required extensive resection of the EAC, while cases with lesions extending throughout the antrum required smaller resection of the EAC, indicating TEES. Conclusions: By predicting the extent of the needed EAC removal, it is possible to determine whether TEES (a retrograde approach) or canal wall-up mastoidectomy, which preserves as much of the EAC as possible, should be performed. We believe that our findings will contribute to the success of middle ear surgeries and the implementation of robotic surgery in the future.
Catecholaminergic Polymorphic Ventricular Tachycardia: Clinical Characteristics, Diagnostic Evaluation and Therapeutic Strategies
Authors: Aggarwal Abhinav , Stolear Anton , Alam Md Mashiul , Vardhan Swarnima , Dulgher Maxim , Jang Sun-Joo , Zarich Stuart W.
Published: March 2024

Catecholaminergic polymorphic ventricular tachycardia (CPVT) is a severe hereditary arrhythmia syndrome predominantly affecting children and young adults. It manifests through bidirectional or polymorphic ventricular arrhythmia, often culminating in syncope triggered by physical exertion or emotional stress which can lead to sudden cardiac death. Most cases stem from mutations in the gene responsible for encoding the cardiac ryanodine receptor (RyR2), or in the Calsequestrin 2 gene (CASQ2), disrupting the handling of calcium ions within the cardiac myocyte sarcoplasmic reticulum. Diagnosing CPVT typically involves unmasking the arrhythmia through exercise stress testing. This diagnosis emerges in the absence of structural heart disease by cardiac imaging and with a normal baseline electrocardiogram. Traditional first-line treatment primarily involves β-blocker therapy, significantly reducing CPVT-associated mortality. Adjunctive therapies such as moderate exercise training, flecainide, left cardiac sympathetic denervation and implantable cardioverter-defibrillators have been utilized with reasonable success. However, the spectrum of options for managing CPVT has expanded over time, demonstrating decreased rates of arrhythmic events. Furthermore, ongoing research into potential new therapies including gene therapies has the potential to further enhance treatment paradigms. This review aims to succinctly encapsulate the contemporary understanding of the clinical characteristics, diagnostic approach, established therapeutic interventions and the promising future directions in managing CPVT.
Difference in Buccal Gingival Thickness between the Mandible and Maxilla in the Aesthetic Zone: A Systematic Review and Meta-Analysis
Authors: Schwarz Linda , Andrukhov Oleh , Rausch Marco Aoqi , Rausch-Fan Xiaohui , Jonke Erwin
Published: March 2024

Background: Fragile gingival tissue is a risk factor for the development of gingival recessions. Despite the fact that gingival recessions are more commonly seen around anterior mandibular teeth, previous research has predominantly concentrated on the gingival dimensions in the anterior maxilla. The objective was to systematically compare buccal gingival thicknesses between the upper and lower jaws in individuals with healthy gingival conditions in the aesthetic zone. Methods: A comprehensive search of three databases was carried out until October 2023. Gingival thickness differences between the maxilla and mandible were evaluated by calculating the mean differences along with the corresponding 95% confidence interval (CI). Subgroup analysis was conducted based on the measurement area, measurement method, and tooth category. Results: A total of seventeen studies were included in this systematic review. Eleven studies were included in the quantitative analysis. Quantitative analysis comparing gingival thickness around 2100 teeth in the anterior mandible to 2056 teeth in the anterior maxilla revealed a statistically significant thinner buccal gingiva in the mandible (mean difference: 0.16 mm; 95% CI [−0.24, −0.07]; p = 0.0003). Conclusions: The present systematic review revealed a more delicate buccal gingiva in the anterior mandible. However, further scientific validation is required due to the considerable heterogeneity in study design and the potential presence of confounding variables.
Dermoscopy of Umbilical Lesions—A Systematic Review
Authors: Żółkiewicz Jakub , Sławińska Martyna , Maińska Urszula , Nowicki Roman J. , Sobjanek Michał , Thomas Luc
Published: March 2024

Background: The umbilicus is a fibrous remnant located in the centre of the abdomen. Various entities may be encountered in this special anatomical location; however, little is known about their dermoscopic presentation. The aim of this study was to provide a comprehensive summary of existing evidence on dermoscopic features of umbilical lesions. Methods: Studies assessing dermoscopic images of umbilical lesions were included in this study. No age, ethnicity or skin phototype restrictions were applied. Papers assessing lesions outside of the umbilical area, lacking dermoscopic images and/or dermoscopic description and not related to the topic were excluded. Embase, Medline and Cochrane Library were searched from inception to the end of May 2023. The Joanna Briggs Institute critical appraisal tools were used to evaluate the risk of bias of the selected studies. The quality and the level of evidence of included studies were assessed according to the Oxford 2011 Levels of Evidence. Thirty-four studies reporting a total of 39 lesions met the inclusion criteria and were included in qualitative analysis. Results: A qualitative synthesis of the following entities was performed: melanoma, nevi, basal cell carcinoma, fibroepithelioma of Pinkus, Sister Mary Joseph nodule, mycosis fungoides, dermatofibroma, endometriosis, epidermal cyst, granuloma, intravascular papillary endothelial hyperplasia, lichen planus, omphalolith, seborrheic keratosis, and syringoma. Conclusions: Dermoscopy is a non-invasive technique that may be useful in the differential diagnosis of umbilical lesions. The main limitations of this study were lack of a high level of evidence in the studies and the lack of uniformity in applied dermoscopic terminology between included studies.
Dermatologic Effects of Selumetinib in Pediatric Patients with Neurofibromatosis Type 1: Clinical Challenges and Therapeutic Management
Authors: Borgia Paola , Piccolo Gianluca , Santangelo Andrea , Chelleri Cristina , Viglizzo Gianmaria , Occella Corrado , Minetti Carlo , Striano Pasquale , Diana Maria Cristina
Published: March 2024

Background: Plexiform neurofibromas (pNFs) are benign neoplasms, primarily originating from Schwann cells, posing challenges in patients with type 1 neurofibromatosis (NF1) due to pain, disfigurement, compression of vital structures and potential for malignancy. Selumetinib, a MEK1/2 inhibitor, has shown promising results in treating inoperable pNFs, with clinical trials demonstrating tumor volume reduction and improved patient-reported outcomes. Despite its efficacy, dermatologic toxicities may impact the quality of life and treatment adherence. Evaluating the frequency and spectrum of such effects is crucial for effective management. Methods: In a four-year retrospective and prospective study, pediatric NF1 patients with symptomatic, inoperable plexiform neurofibromas (pNFs) were treated with selumetinib. Eligibility criteria included significant morbidity, pNF size exceeding 3 cm or surgical inoperability, and performance status >70%. Hematological, liver, lung and cardiac assessments established baseline health. Selumetinib, orally administered at 25 mg/m2 twice, was administered for two years unless a response warranting extension occurred. Cutaneous AEs were documented and graded by severity according to CTCAE v5.0, with evaluations every three to six months. The impact on symptoms and pNF size was systematically recorded, and biopsies characterized histopathological features in those patients requiring surgery. Results: Twenty patients were enrolled, with an average age at therapy initiation of 11.6 years. Cutaneous side effects were common, with all patients experiencing at least one and a median of two per patient. Xerosis, paronychia and acneiform rash were prevalent. Notably, pre-pubertal individuals were more susceptible to xerosis. Acneiform rash had a higher incidence in older patients and those with skin phototypes II and III. Successful management involved tailored approaches, such as clindamycin for acneiform rash and topical agents for paronychia. Hair abnormalities, including color changes and thinning, occurred, with female patients at higher risk for the latter. Paronychia presented challenges, necessitating various interventions, including surgical approaches. AEs led to treatment suspension in 20% of patients, with tumor rebound observed in 75%. Conclusions: According to our experience, successful management of selumetinib-induced cutaneous AEs requires tailored strategies including surgery. AEs might indirectly determine pNF regrowth due to therapy suspension. We thus emphasize the pivotal role of addressing cutaneous reactions for effective selumetinib management in pediatric patients.