bluuebunny/crossref_metadata_2025 huggingface dataset:
Procesos de enseñanza y aprendizaje significativo asociados a la ingeniería industrial, uso de la lúdica, el modelamiento y la simulación en el laboratorio integral de ingeniería industrial en Unicatólica (lúdicas lab3i)
Authors: Fonseca Villamarín Guillermo Alberto
Published: April 2021

El presente trabajo corresponde al desarrollo de un proyecto de investigación el cual se encuentra en curso y cuya finalidad se enfoca en el establecimiento de los criterios, así como la línea base para coordinar las estrategias pedagógicas y didácticas de la Facultad de Ciencias Básicas e Ingeniería de Unicatólica, en especial aquellas que se asocian a los procesos de enseñanza y aprendizaje propios del quehacer de la Ingeniería Industrial.

 Abstract

The present work corresponds to the development of a research project which is ongoing. Its purpose focuses on the establishment of criteria, as well as a baseline to coordinate pedagogical and didactic strategies for the Faculty of Basic Sciences and Engineering of Unicatólica, especially those associated with the teaching and learning processes of Industrial Engineering.
IAU100 Activities and Recent Developments in Turkish Astronomy
Authors: Ali¸s Sinan
Published: April 2021

In this paper, astronomy activities in Turkey in the year of 2019 are summarized. Especially, public outreach activities and teacher training programs in the framework of IAU 100 celebrations are given. Current status of the Eastern Anatolia Observatory and Turkish Space Agency are also summarized. Finally, recently established working group on the legislation for the light pollution is introduced.
Scientific Tourism, Astronomical Tourism and Possible Solutions of Scientific Tourism
Authors: Minasyan Robert , Nalbandyan Naira
Published: April 2021

The article discusses the ways and prospects of the development of scientific, in particular astronomical, tourism in Armenia.
Efficient and Reusable Silica Gel Supported Metal Ionic Liquid Catalysts for Palmitic Acid Esterification to Biodiesel
Authors: Yingwei Guo , Xuedan Chen , Shiting Yan , Zhengliang Zhang , Yuqin Chen , Lina Zheng , Guangqi Zhu , Xiaoxiang Han
Published: April 2021

A series of silica gel (SG) supported metal ionic liquid catalysts (x[Bmim]Cl-CrCl3/SG) were synthesized and exploited for the esterification of palmitic acid (PA) with methanol (ML) to produce biodiesel efficiently. The 10%[Bmim]Cl-CrCl3/SG catalyst with high surface area and desirable acidity exhibited the best catalytic performance and reusability after six consecutive running cycles. Based on the response surface analysis, the optimal reaction conditions were obtained as follows: methanol/acid mole ratio = 11:1 mol/mol, catalyst amount = 5.3 wt%, reaction time = 65 min, as well as reaction temperature = 373 K, reaching to a biodiesel yield of 96.1%. Further kinetic studies demonstrated that the esterification of PA with ML obeyed 1.41 order kinetics for acid concentration with the activation energy of 16.88 kJ/mol.
Mononuclear Copper(I) Schiff Base Complex Cu((Cl-NO2-ba)2en)I(CH3CN): Synthesis and Crystal Structure
Authors: Aliakbar Dehno Khalaji Aliakbar Dehno Khalaji , Michal Dusek Michal Dusek , Vaclav Eigner and Seyyed Javad Peyghoun Vaclav Eigner and Seyyed Javad Peyghoun
Published: April 2021

New mononuclear copper(I) Schiff base complex Cu((Cl-NO2-ba)2en)I(CH3CN) (1) containing a bidentate Schiff base ligand (Cl-NO2-ba)2en = 2,4-dichloro-5-nitro-benzylidene-1,2-diaminopropane, was prepared in an acetonitrile solution and characterized by elemental analyses (CHN), FT-IR and UV-Vis spectroscopy. Suitable dark-orange single crystals were obtained by slow evaporation of solvent at 5 ºC for several days. Crystal structure of the title compound 1 was determined by single-crystal X-ray diffraction. The complex 1 crystallizes in orthorhombic space group Pna21, a = 16.8634 (5) Å, b = 8.4460 (5) Å, c = 17.4786 (2) Å, V = 2489.45 (17) Å3 and Z = 4. In addition, the title compound 1 was used as new precursor for the synthesis of copper(II) oxide nanoparticles via solid state thermal decomposition. The as prepared CuO product was characterized by FT-IR, XRD and SEM.
Daya Dukung Lingkungan Daerah Aliran Sungai Kayan dan Sembakung Kalimantan Utara Dalam Penyediaan Pangan dan Air
Authors:   Dosen di Universitas Borneo Tarakan, Sutrisno Adi , Wahyuni Etty ,   Dosen Program Studi Agribisnis Fakultas Pertanian Universitas Borneo Tarakan, Titing Deny ,   Agroteknologi Fakultas Pertanian Universitas Borneo Tarakan
Published: April 2021

The purpose of this research was to understand the carrying capacity of Kayan and Sembakung watershed in North Borneo Province, the carrying capacity in providing clean water and how was the trend of the carrying capacity of the water supply in the Kayan and Sembakung watersheds, which were the basis for food supply. The study area was the Kayan and Sembakung watersheds in the administrative area of North Kalimantan Province using an “ecosystem services” approach. The results of the research were as follows: (1) the Kayan and Sembakung watersheds in North Kalimantan Province were dominated by areas that have “high” carrying capacity in providing food; (2) The Kayan Watershed in North Kalimantan Province was dominated by areas that have a “moderate” environmental carrying capacity in water supply, while for the Sembakung watershed it was dominated by areas that have a “high” environmental carrying capacity in water supply; and (3) The carrying capacity of the downstream areas of the Kayan and Sembakung watersheds in the provision of clean water tended to be “Very Low” when the carrying capacity of the downstream ecosystems in the Kayan and Sembakung watersheds as food providers was “High”.
Pemanfaatan Pasir Besi untuk Pembuatan Kitosan Magnetik
Authors:   Kimia, Universitas Syiah Kuala, Rahmi Rahmi , Fathurrahmi Fathurrahmi ,   Kimia, Universitas Syiah Kuala, Lelifajri Lelifajri ,   Kimia, Universitas Syiah Kuala, Mustafa Irfan ,   Kimia, Universitas Syiah Kuala, Susilawati Susilawati ,   Kimia, Universitas Syiah Kuala, Ishmaturrahmi Ishmaturrahmi ,   Kimia, Universitas Syiah Kuala
Published: April 2021

Buku ini menguraikan tentang pemanfaatan pasir besi dalam proses pembuatan kitosan magnetik secara mendalam dari tahap pembuatan sampai pengkajiannya lebih lanjut
Community Awareness of the 2019 Coronavirus Disease (COVID-19) In Tabuk, Saudi Arabia
Authors: G. Analita , A. Maaidah , F.A. Wed , S.A. Mashael , M.A. Asma , H.A. Ohud , H.A. Aryaj , M.A. Noof
Published: April 2021

Community awareness is an essential factor in the control and prevention of communicable diseases, especially the 2019 coronavirus disease (COVID-19). This study investigates the level of COVID-19 awareness in Tabuk, Saudi Arabia in the areas of signs and symptoms, mode of transmission and prevention. A descriptive correlational, cross-sectional study design was used. The researcher-devised questionnaire was validated and was found reliable with Cronbach Alpha of 0.92. The majority of the 501 participants who responded to the questionnaire were extremely aware of COVID-19 in terms of signs and symptoms, modes of transmission and preventive measures. YouTube, Television and WhatsApp were the main sources of information regarding COVID-19. The awareness level about COVID-19 in Tabuk was exceptional based on the questionnaire scores, and the source of information reflected the concern of the studied population.
Effect of Role School Committee and School Operational Fund on Quality of Education
Authors: Efendi Rusdi , Fitria Happy , Nurkhalis Nurkhalis
Published: April 2021

This study determined whether there is any influence and how much influence the role of the school committee and school operational assistance programs on the quality of education. This research was conducted in SMP Negeri Rambang, Muara Enim. This type of research is quantitative research. While the method in this research uses the partial correlation method. The sample in this study were 45 educators and teaching staff at the school. The data collection technique in this study used a questionnaire. The results of this study showed that 1) there is a relationship between the role of the school committee and the school operational assistance program; 2) there is an influence between the role of the school committee on the quality of education; 3) there is an influence between the school operational assistance program on the implementation of education quality; and 4) there is a significant joint effect between the role of the school committee and the school operational assistance program on the quality of education.
Indonesian as the Language of ASEAN During the New Life Behavior Change 2021
Authors: Wardhana Dian Eka Chandra
Published: April 2021

Indonesian is studied and used as a language in ASEAN because Indonesian is the lingua franca. In WordPress posts, the Indonesian language ranks third after English and Spanish. However, the attitude of native Indonesian speakers is still negative, so the Indonesian language UN scores (30% do not pass) are lower than the English national examination scores (only 5% do not pass). The purpose of this research is to describe the tendency of using Indonesian in ASEAN. The research data is in the form of information about the use of Indonesian in ASEAN. The data were collected online from members of 5 (international) communities, such as MLI, KSLI (alumni), AMCCA, and lecturers who had assisted students during internships through SEA teachers, SEAMEO, and youth exchanges with partner universities. This research data analysis using the Delphi technique and inter-subjectivity test. The findings are based on the panelist reliability test with a value of 0.7441 greater than 0.70, it is concluded that the model is consistent. Besides, the model reliability test was also carried out, and the result was that the value of r11 = 0.874 was greater than 0.70, so the model was reliable. The tendency in the use of Indonesian in ASEAN carries native speakers of conditioning results (nurture nativism) with the tendency as mentioned above is valid and reliable.
Using Social Media in the Selection Process: An Ethical Perspective for Employers and Applicants
Authors: Johnson Andrew F. , Roberto Katherine , Myers Elwin
Published: April 2021

Social media is a widely popular communication platform that has been quickly adopted by millions of users world-wide (Statista, 2020). The vast amount of available information on social media is increasingly utilized in the selection process (Landers & Schmidt, 2016). This manuscript considers the use of social media in the selection process through the lens of two ethical perspectives. The utilitarian perspective provides an ethical lens with which to discuss the actions of employers. Alternatively, the deontological perspective provides an ethical lens to better understand the position of job seekers. The manuscript concludes with a discussion and recommendations for practice.
Are Millennials More Likely To Be Abusive Supervisors?
Authors: Green Jason , Timmerman Thomas
Published: April 2021

Demographic shifts in the labor force provide a variety of challenges for managers and leaders in organizations. Throughout history, shifts such as the greater participation of females in the workforce, greater ethnic/racial diversity, and increasing internationalization paired with age-related impacts have sparked changes in societal attitudes and management practices. Generational differences are also challenging because people born in different time periods may grow up in periods with differing values and social norms. As a result, people from different generations may have different expectations about how employees should be managed. Over the last several years, a great deal of research has addressed the unique characteristics of Millennials as they entered the workforce, but very little research has addressed the next step in the careers. This research focuses on the increasing role of Millennials in leadership as they increase they become the most active generation in the workforce.
Gamification and Technology-Based Learning: Uncovering the Potential of Using Games in Language Teaching and Learning
Authors: Abdeen Fahad H , Albiladi Waheeb
Published: April 2021

The use of games in education has received much attention from educators who perceive games as a motivational tool that can enhance their teaching and learning practice. Gamification in education is a relatively new field that promotes the use of games for educational purposes. Gamification or game-bases teaching is a growing trend among educational institutions, which use it to promote training, develop problem-solving skills in learners, and enhance the learning experience. The present paper aims to revisit the literature on the use of gamification in educational settings. Specifically, the paper discusses the use of gamification for teaching and learning English in the ESL/EFL context. Games have been used effectively with language learners to develop their skills in speaking, listening, writing, reading, and grammar.
HRV Biofeedback and Addiction: Rehabbing Body, Mind and Spirit
Authors: Hudson Amy
Published: April 2021

Addiction is a devastating disease of the body, the mind, and even the personality. Recent research shows that heart rate variability biofeedback can help the alcoholic/addict recover in three crucial ways, namely (1) treating the associated comorbidities (depression, anxiety, chronic pain), (2) treating the physiology around craving, and (3) returning to a loving and nurturing relationship with one's own body instead of an abusive and exploitive one.
Reviewer Acknowledgements for Asian Social Science, Vol. 17, No. 5
Authors: Zhang Jenny
Published: April 2021

Reviewer Acknowledgements for Asian Social Science, Vol. 17, No. 5 2021.
Influence of Vibroacoustic Therapy on Local Status and Rehabilitation of Post-TKR and Post-THR patients
Authors: Kędzierska Katarzyna , Synder Marek , Kozłowski Piotr
Published: April 2021

Background. Rehabilitation following major joint replacement surgery is an extremely important part of complementary treatment after the surgical procedure. To obtain the best final treatment outcome possible, apart from improvements in surgical technique, new methods of rehabilitation are still being sought and implemented to increase its effectiveness, safety and patient comfort. One such technique is vibroacoustic therapy, a method of treatment based on the direct transmission of audible sound vibrations through a sound transmitter to the patient’s body. The present study assessed the effectiveness of vibroacoustic therapy in early postoperative rehabilitation of post-TKR and post-THR patients.
Material and methods. The study involved 60 post-TKR and post-THR patients divided into two groups depending on the type of surgery. Each group was further divided into an experimental group treated with the VITAFON-2 apparatus and a control group treated with a placebo apparatus; all patients also underwent routine kinesiotherapy that is offered at the hospital. Vibroa­coustic treatment was carried out and evaluated during the first 4 days following surgery. Symptom intensity, range of motion of the operated joints, oedema in the operated limb and haematoma absorption were assessed.
Results. Postoperative vibroacoustic therapy performed during the first 4 post-operative days reduced pain more significantly than kinesiotherapy alone. It also clinically improved the absorption of post-traumatic haematomas in post-TKR patients insignificantly better than kinesiotherapy. In post-THR patients who had undergone an anterolateral approach procedure, phoning (vibroacoustic stimulation) significantly sped up the rate of recovery of normal internal rotation angles in the operated joints.
Conclusions. 1. Vibroacoustic therapy applied topically in post-TKR patients exerts a significant positive effect on reducing pain intensity. 2. Topical vibroacoustic therapy does not significantly reduce the oedema around the operated hip and knee joints or increase their range of motion. 3. Vibroacoustic therapy accelerates the absorption of postoperative subcutaneous haematomas in a clinically visible manner.
The business model in the light of the Conceptual framework for financial reporting of 2018
Authors: Karwowski Mariusz
Published: April 2021

Purpose: The purpose of the article is to indicate the possible impact of the business mod-el on financial statements in the light of the Conceptual Framework for Financial Report-ing (CF) of 2018.
Methodology/approach: The current state is presented (the basis were CF of 2018), and value judgments are formulated regarding the considerations contained in the article.
Findings: The business model has a limited influence on the scope of information included in financial statements. Measurement (and the associated choice of accounting policies) and the presentation and disclosure of information are areas of financial reporting in which the business model may apply.
Originality/value: The attempt to indicate that the business model – although not directly – has an impact on some of the principles set out in the thoroughly rebuilt and hitherto un-explored CF.
The economic nature of deferred income and the accuracy of the assessment of financial condition ratios
Authors: Witczak Radosław , Zimny Artur
Published: April 2021

Purpose: Deferred income is one of the elements that may affect the accuracy of financial analysis. In many countries, it is recognized as a liability. The purpose of this article is to assess whether the economic nature of deferred income items is closer to equity or liabili-ties and to evaluate how their different treatment affects the accuracy of the assessment of the entity’s financial condition. The research hypothesis assumes that certain categories of deferred income are, by their economic nature, closer to equity than to liabilities, and their different treatment significantly affects the accuracy of the assessment of the entity’s fi-nancial condition. Methodology/approach: The research methodology includes a critical analysis of the literature data and legal acts, the induction method, the descriptive method, and statistical methods. Findings: The analysis showed that the economic character of deferred income varies; some items of deferred income can be classified as liabilities while the others are equity-type. The latter constitute a considerable share in the balance sheets of some entities. It has been found that treating them as equity while calculating financial ratios significantly affected their values. Research limitations/implications: There are no grounds to reject the hypothesis. The study indicates the necessity to analyze the financial condition using modified financial ratios. Originality/value: The study broadens the discussion of the economic nature of deferred income and improves the methodology and accuracy of the entity’s financial analysis.
Bayesian Forcasting Model – 2020 Presidential Elections in the United States of America
Authors: Raczyńska Maria
Published: April 2021

The article describes and explains a prior centric Bayesian forecasting model for the 2020 US elections.The model is based on the The Economist forecasting project, but strongly differs from it. From the technical point of view, it uses R and Stan programming and Stan software. The article’s focus is on theoretical decisions made in the process of constructing the model and outcomes. It describes why Bayesian models are used and how they are used to predict US presidential elections.
Assessment and Treatment of Addictions in Community Corrections
Authors: D. Armstrong Jacob , Bauman Amy , J. Moroney Krystal , Brendan Clark C.
Published: April 2021

This chapter discusses the treatment of substance use disorders within community corrections populations. The history of substance abuse treatment within correctional populations is outlined to provide context for the current diversion and rehabilitation models currently in use. Common systems where treatment is provided such as mental health court, drug court, and TASC are described. Common forms of therapy including Cognitive Behavioral Therapy, Mindfulness, social skills training, pharmacotherapy, and smoking cessation are discussed. This chapter focuses on their effectiveness as well as how these forms of therapy differ in community corrections as compared to other populations. Finally, recommendations and future directions for research are provided.
Regulation of Morphological and Functional Aspects of Sexual Dimorphism in the Brain
Authors: Orikasa Chitose
Published: April 2021

Sexual dimorphism of the adult brain regulates sex-dependent functions including reproductive and neuroendocrine activities in rodents. It is determined by sex steroid hormones during a critical perinatal period in female and male rodents. Sex steroids act on each nuclear receptor in the brain and control different physiological and neuroendocrine functions and behaviors. Several regions of the brain show evident morphological sex differences that are involved in their physiological functions. This review addresses and focuses largely on the role of sex-dependent differences in the brain, and their crucial functions in animal models. Particularly, recent intriguing data concerning the diversity of neuronal functions and sexual dimorphism are discussed.
COVID-19 and Cancer: Biological Interconnection and Treatment
Authors: Jyotsana Nidhi
Published: April 2021

The COVID-19 pandemic has affected more than 125 million lives worldwide and more than 2.5 million people have died so far. Cancer in itself increases the risk of infection especially, cancer patients undergoing cancer-associated treatments are more susceptible to SARS-CoV2 infection. However, many questions related to the biological interconnection between the two diseases remain to be answered. This chapter summarizes some of the biological components that connect cancer to COVID-19 and provide knowledge to not only understand but also, target the co-morbidities.
Conjunto habitacional Residencial Macapaba, na cidade Macapá-AP: direito à cidade?
Authors: Dos Santos Naiara Videira , Ferreira Moura Edila Arnaud
Published: April 2021

Este trabalho objetiva analisar o direito à cidade a partir da transferência de moradores para o conjunto habitacional de moradia popular, o Residencial Macapaba, localizado na cidade de Macapá-AP. O empreendimento faz parte do Programa Minha Casa Minha Vida II, voltado à população da Faixa I, pessoas de baixa renda e em situação de vulnerabilidade socioeconômica. Nesse estudo, aborda-se o direito à cidade na inter-relação com o direito à educação, à saúde, ao transporte, ao lazer e à segurança, considerados fundamentais para promover o acesso de pessoas à cidade e aos seus recursos. A pesquisa demonstrou limitações impostas aos novos moradores para a efetivação do direito à cidade com impacto no alcance da qualidade de vida urbana. Como instrumentos para a análise fez-se uso da pesquisa bibliográfica, observação direta e a aplicação de questionários semiestruturados com 40 moradores da Fase I do empreendimento.
La gripe hespanhola: memórias histórico-literárias na ficção amazônica do século XX
Authors: Smith Júnior Francisco Pereira
Published: April 2021

Este artigo ter por objetivo fazer uma análise da crônica Preces, Remédio Contra Epidemia, de Campos Ribeiro, obra de 1942. O ambiente apresentado por esta narrativa serão as memórias do início do século XX, mais precisamente os fatos relacionados à epidemia da gripe hespanhola ocorrida na cidade de Belém do Pará, localizada ao norte do Brasil. O texto apresenta ao leitor a possibilidade de uma reflexão a respeito do auge da epidemia da gripe espanhoa na metrópole amazônica após a economia da borracha e assim permite revisitar os dramas da população naquela época. Para essa discussão foram trazidos os textos literários de Ribeiro (2005), Mendonça (2002) e Meira (1976). Para a discussão teórica trago os estudos de Bosi (1994) e Abreu Júnior (2018).
Apresentação
Authors: Araújo Johny Santana de , Teixeira Nuno Severiano
Published: April 2021

Dossiê - Guerras e conflitos em escala global no Tempo Presente
HIYA, FEMINILIDADE E GÊNERO
Authors: Benato Sandra
Published: April 2021

Resumo: Este artigo nasceu do “desassossego”, como diria Fernando Pessoa. Aqueles que conhecem o trabalho de Ibn ‘Arabī sabem da importância do feminino no seu pensamento e na consolidação das suas experiências espirituais. No entanto, ele também afirma que a mulher é segunda ao homem, surge de uma costela deste e lhe é inferior em um grau. Natural o desassossego, uma sensação de pinçamento cirúrgico e dolorido que não apenas inquieta a alma, mas penetra silenciosamente na sua carne mais profunda. Desfazer este nó intangível - mas opressor - é o que vamos tentar aqui, usando as próprias palavras do Šayḫ como fio condutor, a partir de seus vários conceitos associados à “triplicidade” como fundamento da vida.

Abstract: This article springs out of a “disquietness”, as Fernando Pessoa would say. Those who are familiar with Ibn ‘Arabī’s work know how important is the feminine in his thought as well in the consolidation of his spiritual experiences. However, he also states that the woman is second to man, rises from his rib and is one degree inferior to him. The “disquietness” so happen, naturally, as a sensation of a surgical and painful clamping that not only distresses the soul, but silently penetrates into its deepest flesh. To untie this intangible - but oppressive - knot, is what we will try here, by using the Sheikh’s very words as a guiding thread, looking for the various forms where his concept of triplicity shows up as foundation of life.
'Storytelling' en El Cairo: el desfile dorado de los faraones
Authors: Casal Maceiras Olga
Published: April 2021

Egipto asombra al mundo con su desfile dorado de los faraones, un evento espectacular en el que las momias de veintidós reyes y reinas de la antigüedad recorrieron el trayecto que les llevaría hasta su nuevo y definitivo emplazamiento: el Museo Nacional de la Civilización Egipcia. Una puesta en escena basada en técnicas de storytelling reviste un acto cuyo objetivo principal es la promoción turística internacional y la revitalización de la marca país, tras un duro año de pandemia que ha mermado la actividad del sector.
EEG-based detection of the locus of auditory attention with convolutional neural networks
Authors: Vandecappelle Servaas , Deckers Lucas , Das Neetha , Ansari Amir Hossein , Bertrand Alexander , Francart Tom
Published: April 2021

In a multi-speaker scenario, the human auditory system is able to attend to one particular speaker of interest and ignore the others. It has been demonstrated that it is possible to use electroencephalography (EEG) signals to infer to which speaker someone is attending by relating the neural activity to the speech signals. However, classifying auditory attention within a short time interval remains the main challenge. We present a convolutional neural network-based approach to extract the locus of auditory attention (left/right) without knowledge of the speech envelopes. Our results show that it is possible to decode the locus of attention within 1–2 s, with a median accuracy of around 81%. These results are promising for neuro-steered noise suppression in hearing aids, in particular in scenarios where per-speaker envelopes are unavailable.
Response-based outcome predictions and confidence regulate feedback processing and learning
Authors: Frömer Romy , Nassar Matthew R , Bruckner Rasmus , Stürmer Birgit , Sommer Werner , Yeung Nick
Published: April 2021

Influential theories emphasize the importance of predictions in learning: we learn from feedback to the extent that it is surprising, and thus conveys new information. Here, we explore the hypothesis that surprise depends not only on comparing current events to past experience, but also on online evaluation of performance via internal monitoring. Specifically, we propose that people leverage insights from response-based performance monitoring – outcome predictions and confidence – to control learning from feedback. In line with predictions from a Bayesian inference model, we find that people who are better at calibrating their confidence to the precision of their outcome predictions learn more quickly. Further in line with our proposal, EEG signatures of feedback processing are sensitive to the accuracy of, and confidence in, post-response outcome predictions. Taken together, our results suggest that online predictions and confidence serve to calibrate neural error signals to improve the efficiency of learning.
The hypoferremic response to acute inflammation is maintained in thalassemia mice even under parenteral iron loading
Authors: Sanyear Chanita , Chiawtada Buraporn , Butthep Punnee , Svasti Saovaros , Fucharoen Suthat , Masaratana Patarabutr
Published: April 2021

Background

Hepcidin controls iron homeostasis by inducing the degradation of the iron efflux protein, ferroportin (FPN1), and subsequently reducing serum iron levels. Hepcidin expression is influenced by multiple factors, including iron stores, ineffective erythropoiesis, and inflammation. However, the interactions between these factors under thalassemic condition remain unclear. This study aimed to determine the hypoferremic and transcriptional responses of iron homeostasis to acute inflammatory induction by lipopolysaccharide (LPS) in thalassemic (Hbbth3/+) mice with/without parenteral iron loading with iron dextran.

Methods

Wild type and Hbbth3/+ mice were intramuscularly injected with 5 mg of iron dextran once daily for two consecutive days. After a 2-week equilibration, acute inflammation was induced by an intraperitoneal injection of a single dose of 1 µg/g body weight of LPS. Control groups for both iron loading and acute inflammation received equal volume(s) of saline solution. Blood and tissue samples were collected at 6 hours after LPS (or saline) injection. Iron parameters and mRNA expression of hepcidin as well as genes involved in iron transport and metabolism in wild type and Hbbth3/+ mice were analyzed and compared by Kruskal–Wallis test with pairwise Mann–Whitney U test.

Results

We found the inductive effects of LPS on liver IL-6 mRNA expression to be more pronounced under parenteral iron loading. Upon LPS administration, splenic erythroferrone (ERFE) mRNA levels were reduced only in iron-treated mice, whereas, liver bone morphogenetic protein 6 (BMP6) mRNA levels were decreased under both control and parenteral iron loading conditions. Despite the altered expression of the aforementioned hepcidin regulators, the stimulatory effect of LPS on hepcidin mRNA expression was blunt in iron-treated Hbbth3/+ mice. Contrary to the blunted hepcidin response, LPS treatment suppressed FPN1 mRNA expression in the liver, spleen, and duodenum, as well as reduced serum iron levels of Hbbth3/+ mice with parenteral iron loading.

Conclusion

Our study suggests that a hypoferremic response to LPS-induced acute inflammation is maintained in thalassemic mice with parenteral iron loading in a hepcidin-independent manner.
La percepción del impacto de la maternidad y la paternidad en la carrera científica en Ciencias de la Vida en España
Authors: Pindado Sanz-Cruzado Sheyla , Santos Ana M. C. , Ruiz-Benito Paloma , Villén-Pérez Sara
Published: April 2021

La menor representación de las mujeres respecto a los hombres en etapas avanzadas de la carrera científica se ha relacionado con diversos factores, como el tiempo dedicado a la maternidad. Para conocer la percepción del impacto de la maternidad y la paternidad en el desarrollo de la carrera científica en Ciencias de la Vida en España, se ha realizado una encuesta a 324 investigadores. La mayoría de las personas investigadoras perciben que la crianza tiene un efecto negativo en el desarrollo de su carrera, especialmente en la de las mujeres y cuando los hijos son pequeños. En consonancia, las mujeres reducen el tiempo dedicado al trabajo para cuidar de los hijos más que los hombres. Además, más de la mitad de las personas investigadoras declara haber modificado sus planes de natalidad por su carrera científica. Estas personas proponen medidas para la conciliación familiar y laboral que podrían ayudar a mejorar su panorama.
Uniendo macro y microclima en paisajes de montaña: una aproximación conceptual e instrumental
Authors: Zamora Regino , Pérez-Luque Antonio Jesús , Guerrero-Alonso Pablo David , Moreno-Llorca Ricardo , Merino-Ceballos Manuel , Ros-Candeira Andrea
Published: April 2021

Los efectos del cambio climático se manifiestan cada vez con más claridad en todo el planeta. La mala noticia es que los ecosistemas de montaña están entre los más afectados por estos cambios. La buena noticia es que la compleja orografía de las montañas genera un mosaico muy heterogéneo de condiciones ambientales, lo que puede ayudar a conservar la biodiversidad y la provisión de servicios de sus ecosistemas. Caracterizar estos microambientes y vincularlos a las respuestas ecofisiológicas, conductuales y demográficas de los organismos es clave para entender su capacidad de persistencia y su posible adaptación a los nuevos escenarios. En esta contribución presentamos nuestra propuesta conceptual e instrumental para caracterizar los microclimas en ecosistemas de montaña y avanzar en el proceso de integración entre macro y microescalas.
A Challenging Case of Critical Coronary Trifurcation Disease–Managed Successfully with Percutaneous Coronary Angioplasty
Authors: Dighe Sunil , Munde Kalyan , Kalantri Piyush , Bodke Mahesh , Khan Zahidullah
Published: April 2021

Coronary trifurcation lesions are a complex group of lesions. Percutaneous intervention of such trifurcation lesions which involve left anterior descending artery, left circumflex artery and RAMUS artery is difficult task. Trifurcating coronary artery disease is a complex atherosclerotic process involving the origin of one or more of three side branches arising from a main trunk. The approach to treat trifurcation lesions has not been standardized. We describe a technique to percutaneously treat this lesion using routine day-to-day hardware and a unique two guide catheter technique.

We present a case admitted in our hospital with unstable angina. CAG done suggestive of triple vessel disease and later PTCA was done. Staged PTCA was planned Initially RCA and subsequently Trifurcation PTCA was done for left system.No postprocedural complication was observed and then patient was discharged on third day.
Interactive Effect of Elevated CO2 and Drought Stress on Leaf Anatomy in Brassica Species
Authors: Das Ranjan
Published: April 2021

The aim of present study was to understand how the ultrastructure of the leaf mesophyll cells in Brassica leaf can be altered under elevated CO2 by interactive effect of elevated CO2 on leaf anatomy and ultra structure of Brassica species under moisture stress conditions. Results of the experiment revealed that the crop genotypes differ greatly in response to elevated CO2 and moisture stress conditions. Elevated CO2 brought about an increase in cell and chloroplast expansion in Brassica genotypes. Elevated CO2 also increased the thickness of epidermis, size ofmesophyll cells, accumulation of starch and size and number of starch granules per chloroplast in Brassica juncea and Brassica juncea cultivars. These alterations in the ultra structure of cells in plants might help to plant adjustment to changing climate in the future.
Staffing, Supervision and School Discipline as Determinants of Teachers’ Job Commitment in Public Secondary Schools of Delta State
Authors: Asoro Ataine Juliet
Published: April 2021

The study was conducted to examine how staffing, supervision and school discipline could determine teachers’ job commitment in public secondary schools, Delta State. The correlational survey was adopted for this study. The population comprises of 13,484 principals and teachers in public secondary schools in Delta State. Purposive sampling method was used to sample 674 participates. Two instruments were self-developed for data collection, the instruments were titled “Staffing, Supervision, School-discipline Questionnaire (SSSQ) and Teachers’ Job Commitment Questionnaire (TJCQ). The instrument was validated through face and content validity. Additionally, the instruments were exposed to Cronbach alpha co-efficient and reliability test yielding coefficients of .81 and .77 was obtained for School-discipline Questionnaire (SSSQ) and Teachers’ Job Commitment Questionnaire (TJCQ) respectively. Data obtained was loaded into SPSS version 23 to compute results using Pearson Product Moment Correlation Statistics and regression analysis. Finding shows that staffing, supervision and school discipline are positively significant to teachers’ job commitment in Delta State public secondary schools. It is thus recommended that government should ensure that all schools within the state are adequately staffed such that the workload of teachers will reduce.
Correlation between IL-10 as Cancer Biomarker and Demographic Characteristics of Colorectal Cancer Patients
Authors: Hamad Rahin Sh , Shnawa Bushra H. , Al-Ali Shereen J.
Published: April 2021

Colorectal cancer (CRC) is classified as one of the most prevalent cancer types worldwide, with high morbidity and mortality rates. Patients of CRC have been shown to express a detectable cytokine in serum which contributes to cancer pathogenesis. Therefore, the serum interleukin 10 (IL-10) level in CRC patients was investigated in this study. Patients' medical records with CRC admitted to the Rizgary and Nanakali hospitals, Erbil, Iraq was analyzed as the study group compared to the healthy volunteers' control group. Seventy-one serum samples were collected, thirty-one from diagnosed CRC patients and forty from healthy controls. The concentrations of IL-10 in the sera were assessed by enzyme-linked immunosorbent assay (ELISA). The present finding showed that IL-10 Was significantly elevated in CRC patients' sera compared to the control group, suggesting confirmation of its usefulness for detecting CRC patients' prognosis. A non-significant Pearson correlation was detected between IL-10 serum levels and the CRC group's age, gender, and body mass index. Herein is the first study on the evaluation of IL-10 levels in CRC patients in Kurdistan, Iraq.
Optimasi Penempatan Exhaust Fan dalam Rumah Dengan CFD
Authors: Sarumaha Yonathan K. A. , Sugondo Amelia
Published: April 2021

Pengkondisian udara dalam ruangan sangatlah penting. Hal ini dapat mengurangi sick building syndrome (SBS) yang dapat mengganggu aktifitas penghuni. Salah satu cara untuk mengkondisikan udara adalah dengan ventilasi mekanik. Penempatan exhaust fan sebagai ventilasi mekanik guna mendapatkan posisi optimum perlu dikaji. Pengkajian dilakukan dengan melakukan simulasi rumah 12.5m x 8.2m menggunakan Autodesk CFD 2019. Simulasi dilakukan pada lima posisi penempatan exhaust fan untuk membandingkan suhu dan kecepatannya pada setiap ruangan.

Hasil dari simulasi didapatkan perbedaan suhu udara dan kecepatan udara dari tiap posisi yang diambil pada setiap ruamgan dan dibandingan dengan Tukey yang digunakan sebagai metode perbandingan. Didapatkan bahwa posisi penempatan exhaust fan tidaklah berpengaruh signifikan. Exhaust fan dapat diletakkan dimana saja didalam ruangan. Yang perlu menjadi perhatian adalah volume udara yang disirkulasikan dalam ruangan, agar udara segar dapat masuk dan mengurangi SBS.
Action research as a strategy to implementing a group of pregnantwomen: an analysis according to the participants’ standpoint / Pesquisa-ação enquanto estratégia para implantar grupo de gestantes: uma análise sobre a percepção das participantes
Authors: OLIVEIRA MORAIS JOCASTA MARIA , MAIA MONTEIRO VINICIUS COSTA , OLIVEIRA CARLOS CRISTINA VIRGINIA , DA SILVA WANDERLEY FERNANDES , MESQUITA DE SOUSA KEROLLAINY YORRANY , MENDES ADRIELLY FONSECA
Published: April 2021

Objetivo: Desta forma o estudo teve o objetivo de verificar a percepção das mulheres relativa do emprego da metodologia pesquisa-ação no desenvolvimento de um grupo de gestantes. Método: Pesquisa de abordagem qualitativa e tem como cenário a clínica integrada de saúde da Universidade Potiguar, na cidade de Mossoró-RN. Participaram do estudo cinco gestantes que realizaram o pré-natal nesta unidade. Para a coleta de dados foi utilizada a metodologia da entrevista semiestruturada e a análise realizada através do Discurso do Sujeito Coletivo. Resultados: Evidenciou-se que o grupo auxiliou as gestantes na quebra de tabus e fortalecimento do vínculo materno infantil, oferecendo maior tranquilidade nessa fase importante da vida familiar, permitindo a ela expressar os seus medos, anseios e expectativas, além de proporcionar troca de experiências. Conclusão: Considera-se que o grupo é um espaço de aprendizagem para as gestantes e profissionais de saúde e que trazem melhorias consubstanciais no desenvolvimento da gravidez.
Iterative parameter and order identification for fractional‐order nonlinear finite impulse response systems using the key term separation
Authors: Wang Junwei , Ji Yan , Zhang Chen
Published: April 2021

This article considers the parameter estimation for a fractional‐order nonlinear finite impulse response system with colored noise. For the fractional‐order systems, the challenge and difficulty are to identify the order and parameters of the systems simultaneously under colored noise disturbances. In order to reduce the problem of redundant parameter estimation, the output form of the system can be expressed by a linear combination of unknown parameters through the separation of the key term separation. A key term separation auxiliary model gradient‐based iterative algorithm is derived by using the negative gradient search. Meanwhile, to achieve the higher estimation accuracy, we propose a key term separation auxiliary model multiinnovation gradient‐based iterative algorithm by utilizing the multiinnovation theory. Finally, the simulation results test the effectiveness of the proposed algorithms.
Sugar Functionalization of Silks with Pathway‐Controlled Substitution and Properties
Authors: Sahoo Jugal Kishore , Hasturk Onur , Choi Jaewon , Montero Maria M. , Descoteaux Marc L. , Laubach Isabel A. , Kaplan David L.
Published: April 2021

Silk biomaterials are important for applications in biomedical fields due to their outstanding mechanical properties, biocompatibility, and tunable biodegradation. Chemical functionalization of silk by various chemistries can be leveraged to enhance and tune these features and enable the expansion of silk‐based biomaterials into additional fields. Sugars are particularly relevant for intracellular communication, signal transduction events, as well as in hydrated extracellular matrices such as in cartilage, vitreous, and brain tissues. Multiple reaction pathways are demonstrated (carboxylation of serines followed by carbodiimide coupling with glucosamine, carboxylation of tyrosines followed by carbodiimide coupling with glucosamine; direct carbodiimide coupling of the inherent carboxylic acids of silk (aspartic and glutamic acid) with glucosamine) for the covalent conjugation of glucosamine onto silk with characterization by proton nuclear magnetic resonance (1H‐NMR), liquid chromatography tandem mass spectroscopy (LC‐MS), water contact angle (WCA), and Fourier transform infrared (FTIR) spectroscopy. The results indicate that different pathways substitute different amounts of glucosamine onto silk chains, with control over resulting material properties, including hydrophobicity/hydrophilicity and biological responses. The aqueous processability of these conjugates into functional material formats (films, sponges) is assessed. These new classes of bio‐inspired materials can lead to multifunctional biomaterials for potential applications in different fields of biomedical engineering.
Salty Ice Electrolyte with Superior Ionic Conductivity Towards Low‐Temperature Aqueous Zinc Ion Hybrid Capacitors
Authors: Sun Yinglun , Ma Hongyun , Zhang Xiaqing , Liu Bao , Liu Lingyang , Zhang Xu , Feng Jianze , Zhang Qingnuan , Ding Yunxia , Yang Bingjun , Qu Liangti , Yan Xingbin
Published: April 2021

Aqueous electrochemical energy storage (EES) devices have attracted considerable attention due to their advantages of low cost and high safety. However, the freeze of aqueous electrolytes usually causes the dramatic loss of ionic conduction capacity, thereby seriously restricting the low‐temperature application of such EES devices. Herein, different from traditional frozen electrolytes, a Zn(ClO4)2 salty ice with superior ionic conductivity (1.3 × 10−3 S cm−1 even at −60 °C) is discovered. It is attributed to the unique 3D ionic transport channels inside such ice, which enables the fast transport of both Zn2+ ions and ClO4− ions inside the ice at low temperatures. Using this Zn(ClO4)2 salty ice as an electrolyte, as‐built zinc ion hybrid capacitor is able to work even at −60 °C (with 74.2% of the room temperature capacity), and exhibits an ultra‐long cycle life of 70 000 cycles at low temperature. This discovery provides a new insight for constructing low‐temperature EES devices using salty ices as electrolytes.
Polypeptides–Drug Conjugates for Anticancer Therapy
Authors: Zhang Yu , He Pan , Zhang Peng , Yi Xuan , Xiao Chunsheng , Chen Xuesi
Published: April 2021

Polypeptides are an important class of biodegradable polymers that have been widely used in drug delivery field. Owing to the controllable synthesis and robust side chain‐functionalization ability, polypeptides have long been ideal candidates for conjugation with anticancer drugs. The chemical conjugation of anticancer drugs with polypeptides, termed polypeptides–drug conjugates, has demonstrated several advantages in improving pharmacokinetics, enhancing drug targeting, and controlling drug release, thereby leading to enhanced therapeutic outcomes with reduced side toxicities. This review focuses on the recent advances in the design and preparation of polypeptides–drug conjugates for enhanced anticancer therapy. Strategies for conjugation of different types of drugs, including small‐molecule chemotherapeutic drugs, proteins, vascular disrupting agents, and gas molecules, onto polypeptides backbone are summarized. Finally, the challenges and future perspectives on the development of innovative polypeptides–drug conjugates for clinical cancer treatment are also presented.
The Influence of Ligand Density and Degradability on Hydrogel Induced Breast Cancer Dormancy and Reactivation
Authors: Farino Reyes Cindy J. , Pradhan Shantanu , Slater John H.
Published: April 2021

The role of hydrogel properties in regulating the phenotype of triple negative metastatic breast cancer is investigated using four cell lines: the MDA‐MB‐231 parental line and three organotropic sublines BoM‐1833 (bone‐tropic), LM2‐4175 (lung‐tropic), and BrM2a‐831 (brain‐tropic). Each line is encapsulated and cultured for 15 days in three poly(ethylene glycol) (PEG)‐based hydrogel formulations composed of proteolytically degradable PEG, integrin‐ligating RGDS, and the non‐degradable crosslinker N‐vinyl pyrrolidone. Dormancy‐associated metrics including viable cell density, proliferation, metabolism, apoptosis, chemoresistance, phosphorylated‐ERK and ‐p38, and morphological characteristics are quantified. A multimetric classification approach is implemented to categorize each hydrogel‐induced phenotype as: 1) growth, 2) balanced tumor dormancy, 3) balanced cellular dormancy, or 4) restricted survival, cellular dormancy. Hydrogels with high adhesivity and degradability promote growth. Hydrogels with no adhesivity, but high degradability, induce restricted survival, cellular dormancy in the parental line and balanced cellular dormancy in the organotropic lines. Hydrogels with reduced adhesivity and degradability induce balanced cellular dormancy in the parental and lung‐tropic lines and balanced tumor mass dormancy in bone‐ and brain‐tropic lines. The ability to induce escape from dormancy via dynamic incorporation of RGDS is also presented. These results demonstrate that ECM properties and organ‐tropism synergistically regulate cancer cell phenotype and dormancy.