bluuebunny/crossref_metadata_2025 huggingface dataset:
El Archivo Agrario: problema y posibilidad
Authors: Adrianzén Ponce Cayetana
Published: October 2022

Los archivos proveen la base fundamental para la construcción de narrativas históricas, una premisa esencial para cualquier construcción nacional. En el Perú, sin embargo, los archivos adolecen de los mismos problemas que el Estado: no existen los recursos necesarios para su mantenimiento y tienen fallas en proveer servicios para la población. Se genera entonces una dualidad: problemas materiales, pero con un enorme potencial; la misma que es especialmente aguda en el caso del Archivo Agrario, recuperado en los años setenta por investigadores peruanos, el cual es único en América Latina por la variedad y origen de la documentación. En la presente nota, usando mi propia investigación como ejemplo, se exploran los problemas y las oportunidades que presenta el archivo —y la urgente necesidad de transformarlo radicalmente—.
Análisis de las condiciones de competencia en el mercado de producción del oxígeno medicinal peruano en el contexto de la emergencia sanitaria y políticas públicas pendientes
Authors: Huamán Pérez Rocío , Antayhua López Oscar
Published: October 2022

La Constitución Política del Perú en su artículo 61 regula el deber del Estado de facilitar y vigilar la libre competencia, combatiendo aquellas prácticas que la limiten y el ejercicio abusivo de posiciones monopólicas o dominantes. Sin embargo, no en todos los mercados se presentan condiciones de competencia perfecta, como en el caso del mercado de producción de oxígeno medicinal en el Perú, que se caracteriza por ser oligopólico, en específico un duopolio. Esta situación lleva a reflexionar sobre el rol del Estado en materia económica. 

En el presente artículo, los autores analizan las características del mercado del oxígeno en Perú, con especial énfasis en la producción del oxígeno, los proveedores existentes y las barreras de entrada al mercado; asimismo, se evalúa la pertinencia y necesidad de las políticas dispuestas por el Estado a fin de afrontar la crisis sanitaria y permitir una distribución del oxígeno medicinal que pueda satisfacer la demanda de la población.
El desarrollo urbano sostenible en el bicentenario del Perú independiente: un asunto prioritario en la agenda política 2021-2026
Authors: Villalobos Villalobos Vicente Brayan
Published: October 2022

El crecimiento desordenado y espontáneo de las ciudades y centros poblados es una característica del urbanismo peruano que resulta imposible de negar. En ese orden de ideas, el déficit habitacional y la ocupación informal del suelo, el menoscabo del medioambiente y el deterioro del patrimonio cultural de la nación, son problemáticas que exigen atención prioritaria. 

En el presente artículo, el autor tiene como objetivo exponer la ineficiente planificación del Estado peruano en el desarrollo urbano a partir de los tres ejes problemáticos antes mencionados. En esa misma línea, sostiene que un factor clave en estos problemas ha sido la incoherencia normativa; por ello desarrolla los principales antecedentes históricos de la legislación urbanística peruana, a fin de demostrar que la desarticulación estatal en la gestión del uso del suelo es una característica del urbanismo nacional. Por último, aborda las razones por las que considera que la promulgación de la reciente Ley de Desarrollo Urbano Sostenible es el inicio de una seria planificación urbana en el Perú.
Effect of Particle Size of Starter Diet on Broiler Chicken Performance
Authors: Boussaada T. , Ouachem D. , Lakhdari K. , Benatallah S.A.
Published: October 2022

Background: This study was conducted to determine the effect of particles size of starter diet on growth performance of broiler chickens. Methods: A total of 384 Arbor Acres broiler chicks were usedin a completely randomized design with three treatments and four replicates of 32 birds each.Birds were fed diets with 3 particles sizes of starter diet (T1: 1.0 mm; T2: 0.8 mm; T3: 0.7 mm) during the first week of life. At 7 d, the same starter diet was offered in a crumbled form until 10 d of age. Then, common grower and finisher diets were provided in a pelleted form. Body weight (BW), feed intake (FI), feed conversion ratio (FCR) and mortality rate were evaluated at 7, 14 and 42 days of age. Result: The results showed thatchicks receiving diet with intermediate particles size (0.8 mm) had the higher BW at 7 and 14 d. The FCR was also improved (-6.25%; P less than 0.01) with the same diet at 7 days of age. No feed particle size effect for FIand mortality was observed throughout the 42 d trial. In conclusion, birds fed intermediate particles size (0.8 mm) diet showed better FCR and BW at starter phase. However, no significant effect was observed at slaughter age.
Importancia nutrimental de la diatomea Odontella aurita para su aprobación como suplemento generalmente reconocido como alimento seguro (GRAS) en México
Authors: Sánchez Angulo Leonardo , Trejo Berumen Karla Suzeth , Arredondo Vegaorcid.org Bertha Olivia
Published: October 2022

Diatoms are photosynthetic organisms that are distributed in different habitats. They are responsible for more than 50% of the primary productivity in marine ecosystems. Due to their high content of highly unsaturated fatty acids (HUFA) such as eicosapentaenoic acid (EPA ω3) and carotenoid pigments such as fucoxanthin, they are candidates for the prevention and regulation of human cardiovascular diseases. They have biotechnological interest in the food sector. In this review, we took as a study model the benthic diatom Odontella aurita, isolated from La Ribera, Baja California Sur, Mexico. We present the potential of this species has in terms of a nutritional level as a GRAS food (generally recognized as safe food), and as a viable alternative for a future commercialization.
The Effect Of The Work Environment, Locus Of Control And Motivation On Employees Performance In Baznas Of South Sumatra Province
Authors: Septiatin Aziz , Pajaria Yusiresita , Zuhro Fatimatuz , Rosyada Rosyada
Published: October 2022

The National Amil Zakat Agency (BAZNAS) is the official and only body established by the government which has the task and function of collecting and distributing zakat, infaq and alms (ZIS) at the national level. Human resources are one of the important factors for BAZNAS in carrying out its operational activities. This study aims to examine the effect of work environment, locus of control and motivation on employee performance. This type of research is quantitative research. The sampling technique used in this study is the saturated sampling technique, which is a sampling technique in which all members of the population are used as samples. In this study, researchers used a sample of 32 employees of BAZNAS, South Sumatra Province. The data analysis technique used is multiple regression analysis with the help of SPSS software. The results showed that the work environment had a positive and significant effect on employee performance, locus of control had a positive and significant effect on employee performance and motivation had a positive and significant effect on employee performance.Simultaneously the work environment, locus of control and motivation affect employee performance by 88.7%, while the remaining 11.3% is influenced by other variables that have not been studied or are not included in the regression in this study.
Juzgar la portada por su libro. Reflexiones sobre una obra de Jean Genet y Alberto Giacometti
Authors:   Alianza Francesa de México, Valerio Luna José Alfredo
Published: October 2022

Se narra en este ensayo la complicidad artístico-literaria que sostuvieron el escritor francés Jean Genet y el pintor y escultor suizo Alberto Giacometti, y se analizan los componentes de la portada a la emblemática obra dramática de Genet 'El Balcón', elaborada por el artista suizo.
Cleansing Effects of Soap Containing Liriope Tuber on Facial Skin
Authors: Kim Soo Hyun , Koo Jin Suk
Published: October 2022

Purpose: This study was designed to examine the cleansing effect of Liriope tuber soap on facial skin.Methods: Participants included 40 men and women in their who met the inclusion and exclusion criteria. The facial skin measurement test was carried out to compare skin changes before and after washing the face. To ensure that the experiment was conducted under the same conditions for all participants in the treatment group, the same amount of water and the same towel were used in the same facial regions. Meanwhile, the control group washed their faces with water and a foam cleanser, which is a popular commercial product.Results: After using the Liriope tuber soap, the pore size of participants’ facial skin decreased. Moreover, pigmentation and T-zone oil content significantly decreased.Conclusions: Our results indicate that a facial soap containing Liriope tuber has beneficial effects on facial skin, and it should be considered for use in new natural cosmetics.
IMPACT OF ARTIFICIAL INTELLIGENCE TECHNOLOGY ON ACCOUNTING PROFESSION
Authors: Alghafiqi Burhanuddin , Munajat Enjat
Published: October 2022

The development of Artificial Intelligence technology has changed theaccounting profession. This paper provides a comprehensive overviewof the latest developments in Artificial Intelligence, Big Data, MachineLearning used in business practices in the accounting professionworldwide. This paper explores the evolution of the accountingprofession following the latest technological developments and assessesthe impact of its development in the future. Challenges and opportunitiesposed by Artificial Intelligence relating to accounting professionals andthe process of accounting education. This study uses a normativejuridical approach with library studies with secondary data. This paperprovides an overview of how accounting educators and professionalsrespond to these technological developments and provides furtherdiscussion on what accounting professions, institutions and graduatesshould do to face the challenges of change caused by technologicaldevelopments.
INTERNAL CONTROL MODERATES THE INFLUENCE OF THE FRAUD HEXAGON ON FINANCIAL STATEMENT FRAUD
Authors: Indriana Dina , Anshori Muslich
Published: October 2022

The focus of the research is to investigate internal control in moderating the effect of variables on the elements of The Fraud Hexagon on fraudulent financial reporting. The sample was selected using purposive sampling at public companies in the construction industry in Indonesia for the period 2016 – 2020. The research hypothesis was tested using Multiple Linear Regression Analysis with SPSS. The results of the study indicate that audit fee have a negative effect on financial statement fraud because low audit fees make auditors not give greater effort to the audit process so that the risk of audit quality is getting lower. Low audit quality makes fraudsters believe that their behavior will not be detected, thereby increasing the possibility of financial statement fraud. Meanwhile, internal control will not work effectively if employees do not have the same perception as the company regarding internal control.
Bedaquiline Correlation to QT Interval Prolongation in DR-TB Patients
Authors: Primadana Vandu , Yovi Indra , Estiningsih Dyah Siswanti
Published: October 2022

Introduction: Drug-Resistant Tuberculosis (DR-TB) requires adequate treatment. Bedaquiline is a priority medicine in the treatment regimen of DR-TB. One of the adverse events is QT interval prolongation, which can increase the risk of torsade de pointes (TdP) and lead to death. DR-TB patient screening before starting the treatment and monitoring QT interval during the treatment should be performed. This study aimed to determine Bedaquiline correlation to QT interval prolongation in DR-TB patients.
Methods: This was a retrospective study using an observational design by viewing medical records of DR-TB patients who underwent treatment from January 2019 to March 2022.
Results: This study involved 46 DR-TB patients with a regimen of Bedaquiline. The comparison of Baseline QT intervals before and after one month of therapy showed QT interval prolongation (457.1 ± 18.2 ms and 443.8 ± 10.2 ms; p < 0.001). The comparison of QT intervals before the therapy and six months after the therapy showed prolongation QT intervals (443.8 ± 10.2 ms and 458.4 ± 23.7 ms; p < 0.001). QT intervals after one month of therapy compared to six months after the therapy showed insignificant slight prolongation (457.1 ± 18.2 ms and 458.4 ± 23.7 ms; p = 0.587).
Conclusion: QT interval prolongation occurred in DR-TB patients who received treatment using Bedaquiline regimen. It was seen significantly between baseline QT interval compared to after receiving the therapy for one month and baseline QT interval compared to after receiving the therapy for six months.
Opere Evre II ve III Kolon Kanserli Yaşlı Hastalarda Adjuvan Kemoterapinin Klinik Sonuçları: Gerçek Yaşam Verileri
Authors: ARTAÇ Mehmet , HENDEM Engin , DEMİRKIRAN Aykut , KORKMAZ Mustafa , KARAKURT ERYILMAZ Melek , ARAZ Murat , KOÇAK Mehmet Zahid
Published: October 2022

Bu çalışma, opere evre II ve III kolon kanserli yaşlı hastalarda adjuvan kemoterapinin klinik pratikteki etkinliğini ve tolere edilebilirliğini değerlendirmeyi amaçladı. Hasta popülasyonu adjuvan kemoterapi alan ve almayan grup olarak iki gruba ayrıldı. Gruplar arasında klinik özellikler, genel sağkalım (OS) ve hastalıksız sağkalım (DFS) karşılaştırıldı. OS için bağımsız risk faktörlerini belirlemek için Cox regresyon analizi kullanıldı. Adjuvan kemoterapi alan grup ile almayan arasında, OS için Hazard oranı (HR) 0.80 (%95 Güven aralığı [CI]: 0.66-0.90) (p=0.0025) tespit edildi. Bu grupların PFS'leri arasında istatistiksel olarak anlamlı bir fark yoktu (HR:1.02, %95 GA: 0.75-1,35)(p=0.96). Çok değişkenli analizde (yaş, perforasyon, obstrüksiyon, hastalık evresi, yeterli lenf nodu, tümör tarafı) ve tek değişkenli analizde yaş, OS için bağımsız bir prediktif belirteç değildi. Adjuvan kemoterapi hem evre II hem de evre III kolon kanserli yaşlı hastalarda etkiliydi ve toksisitesi yönetilebilirdi. Adjuvan kemoterapi kararı, kronolojik yaştan ziyade biyolojik yaşına ve hastanın fonksiyonel değerlendirmesine dayanmalıdır.
Adaptasi Alat Ukur Learning Agility pada Karyawan untuk Meningkatkan Organizational Agility: Versi Bahasa Indonesia
Authors:   (1),  (2),  (3), Selvia Wardhani Nurnaifah , Sulastiana Marina , Ashriyana Rezki
Published: October 2022

Learning agility is the willingness and the ability of individuals to engage in active learning in order to adapt activity opportunities from experience, and apply that learning lesson to successfully perform in the new and changing situations and conditions especially for reaching the organizational agility. Learning agility consists of four dimensions: people agility, results agility, mental agility, and change agility. The use of instruments in different cultural backgrounds requires an adaptation process to ensure the valid and reliable measurement results, but until now there has been no research on the adaptation of learning agility measurement instrument in Indonesia. The purpose of this study is to obtain and test the standardized Indonesian version of learning agility instrument. The adaptation process was carried out using the International Test Commission (2016) as a reference. Based on the results of the Confirmatory Factor Analysis (CFA) using JASP 0.13.1.0, it can be concluded that according to the theory, the learning agility model consists of four dimensions: people agility, results agility, mental agility, and change agility. It has a good fit model after several adjustment items are removed. It explains that the resulted model can describe the actual conditions, but with some conditions that must be taken into account.
Kesehatan Mental Pengasuh Informal pada Masa Pandemi Covid-19 (Sebuah Tinjauan Sistematis)
Authors: Nanda Pratiwi Ni Putu Padmadita , Hartini Nurul
Published: October 2022

Informal caregivers are not only at risk to physical health problems but also mental health problems as they take care of patients, especially during COVID-19 pandemic. This is caused by changes in daily activities routine and structure as well as the increased burden in taking care the patients as the consequence of reduced access to formal health services. However the role of informal caregiver is often underappreciated. The study aims to describe the mental health condition of informal caregivers in taking care the patients during the COVID-19 pandemic. The reviews were conducted on two sites which prove the online journals, they are Google Scholar and ScienceDirect and it found nine journal research. The nine journals were evaluated using PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses). The findings show that mental health condition of informal caregivers can be observed from emotional, cognitive, and behavioral variables, with the aspects such as anxiety, fear, distress, depression, quality of life, telehealth, suicidal ideation, health protocol, and changes in lifestyle. Whether caregiving duties during COVID-19 pandemic solely cause mental health problems for informal caregivers remains unclear. Findings from this research are expected to facilitate upcoming research, especially in psychological variables related to informal caregivers who take care patients in the time of COVID-19 pandemic
Misi, Kepemimpinan, Budaya, Kinerja, dan Visi sebagai Tulang Punggung dari Model Organisasi yang Efektif
Authors: Riyono Bagus
Published: October 2022

Organizational models can be used as guidelines for understanding organizations. However, the terms used in the academic world are often not the same as the terms used in the practical world. The lack of consistency of these terms causes these organizational models to be regarded as simply unscientific models. This research was conducted to formulate an integrative concept of organization. This concept will be able to accommodate the terms of the academic world as well as the practical world, so it is expected to be able to standardize the terms in an organizational model. The research method used was the qualitative method, namely meta-ethnography. Meta-ethnography is an approach taken to synthesize some texts and research findings and then reinterpret these texts. The data analyzed in this study is the formulation of organizational models that are well known in the literature, namely the 7-S Model from Pascale and Athos (1981), the Six-Box Model from Weisbord (1976), and the Stream Organizational Model from Porras (1987). The result of the research is the discovery of 12 elements within the organization that systemically have the backbone and the related stuffs. The 12 elements can essentially be condensed into five components which is the backbone of an organization. The backbones of the organization are mission, leadership, culture, performance, and vision. Among the five elements of the backbone, the most complex one is organizational culture, which includes eight interrelated and interdependent elements. The eight elements that build the culture are values, strategy, structure, system, goals, people, skills, and style. In addition, there are environmental forces that influence the running of an organization, they are politics, competition, technology, and population.
Prenatal Exposure to Polycyclic Aromatic Hydrocarbons and Birth Outcomes
Authors: Sram Radim J. , Solansky Ivo , Pastorkova Anna , Veleminsky, Jr. Milos , Veleminsky Milos , Urbancova Katerina , Dvorakova Darina , Pulkrabova Jana
Published: October 2022

Background and objectives: The impact of prenatal exposure to polycyclic aromatic hydrocarbons (PAHs) to birth outcomes as weight, length, head perimeter, placenta weight and Apgar score. Materials and Methods: Two cohorts of children born in the years 2013 and 2014 in Karvina (Northern Moravia, N=144) and Ceske Budejovice (Southern Bohemia, N=198) were studied for the relationship between prenatal exposure to PAHs and growth parameters up to two years of age. PAHs exposure was evaluated according to concentration of benzo[a]pyrene (B[a]P) in polluted air and monohydroxylated PAH metabolites (OH-PAHs) in urine of newborns and their mothers. Data on growth parameters were obtained from pediatric questionnaires up to 24 months. Results: Concentrations of B[a]P were significantly higher in Karvina (p<0.001). OH-PAH metabolites were significantly higher in the mother´s as well as in the newborn’ s urine in Karvina. The length was shorter in newborns in Karvina at birth (p<0.001), but this difference was straightened out during next 3 to 24 months. Birth weight at the delivery did not differ between newborns in Karvina and Ceske Budejovice. Newborns in both locations significantly decreased their weight gain between birth and 3 months after delivery. OH-PAHs metabolites in mother’s or newborn’s urine did not affect birth weight. Top 25% values of concentrations of 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN and the sum of all-OH-PAHs higher than median in the newborn´s urine decreased their length. 2-OH-PHEN top 25% of concentrations in the newborn´s urine decreased their head perimeter, 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, 9-OH-PHEN, 1-OH-PYR, and all-OH-PAHs decreased placenta weight; 2-OH-FLUO, 1-OH-NAP, 2-OH-NAP, 1-OH-PHEN, 2-OH-PHEN, 3-OH-PHEN, 4-OH-PHEN, and all-OH-PAHs decreased Apgar 5´. Conclusions: We observed that higher concentration of PAHs determined as OH-PAHs metabolites in newborn´s urine decreased their length, head perimeter, placenta weight, and Apgar 5´, but did not affect birth weight.
Wavelet Long Short-Term Memory to Fault Forecasting in Electrical Power Grids
Authors: Branco Nathielle Waldrigues , Cavalca Mariana Santos Matos , Stefenon Stefano Frizzo , Leithardt Valderi Reis Quietinho
Published: October 2022

The electric power distribution utility is responsible for providing energy to consumers in a continuous and stable way, failures in the electrical power system reduce the reliability indexes of the grid, directly harming its performance. For this reason, there is a need for failure prediction to reestablish power in the shortest possible time. Considering an evaluation of the number of failures over time, this paper proposes to perform a failure prediction during the first year of the pandemic in Brazil (2020) to verify the feasibility of using time series forecasting models for fault prediction. The Long Short-Term Memory (LSTM) model will be evaluated to obtain a forecast result that can be used by the electric power utility to organize the maintenance teams. The Wavelet transform shows to be promising in improving the predictive ability of the LSTM, making the Wavelet LSTM model suitable for the study at hand. The results show that the proposed approach has better results regarding the evaluation of the error in prediction and has robustness when a statistical analysis is performed.
Optimal Propellant-less Control of a Solar Sail
Authors: Pittella Andre , Sands Timothy
Published: October 2022

: Solar sails use radiation from the sun to generate thrust without any fuel or propellant. Since this is a form of propulsion that has theoretically infinite use, we would like to test its capability on long-term missions by simulating a spacecraft equipped with solar sails to the Sun-Earth L5 Lagrange point. To control the sail angle, which is the main form of control we have over the sail’s performance, we will devise a form of optimal control based on Pontryagin’s Minimum Principle. Simulating the dynamics in MATLAB SIMULINK, we find that such a control method relies on iterating over initial conditions for the co-states to find the necessary parameters for the trajectory to reach the desired point. Therefore, an autonomous control scheme that uses this form of optimal control will need a way to numerically find said initial conditions in order to find the control angle needed at any point in time, which may be computationally intensive.
The Moderator Effect of The Internal Control System on The Financial Success of Corporate Governance
Authors: KANCA Sevda , ÇANKAYA Fikret , DİNÇ Engin , KARAKAYA Aykut
Published: October 2022

In the literature, there are studies investigating whether the internal control system and corporate governance principles have an effect on financial performance. However, there is no study investigating the moderator effect of the internal control system on the financial success of corporate governance. For this purpose, it was examined in this study whether there was a moderator effect of the internal control system on the financial success of corporate governance. The study was conducted on companies in the Borsa Istanbul (BIST) corporate governance index (XKURY). The effectiveness of the internal control system was determined by the survey method, and then corporate governance effectiveness ranking was obtained with corporate governance rating scores. The moderator effect was investigated by regression analysis using the data obtained. As a result of the analysis, it has been determined that the internal control system has a moderator effect on the financial success of corporate governance. On the other hand, it is concluded that although corporate governance is thought to have a moderator effect on the financial performance of the internal control system, it does not. This result indicates that the efficiency of the internal control system should be increased for the financial success of corporate governance in enterprises. The reasons for this theoretically unexpected result were investigated in the study.
Integration of Character Education and Tazkiyah al-Nafs: Perspective of Abū Hasan al-Nadwī
Authors: Mulyadi Mulyadi
Published: October 2022

This article aims to analyze Ab Hasan al-Nadwī’s thoughts on tazkiyah al-nafs. Then, the character values in tazkiyah al-nafs are integrated into the concept of character formulated by the Ministry of Education.The concept of character by the Ministry of Education has a clear nationalism vision but has no technical direction. Then it can be filled with tazkiyah al-nafs by Abū Hasan al-Nadwī who has technical directions. The integration of the concept of character by the Ministry of Education and tazkiyah al-nafs by Abū Hasan al-Nadwī is useful for producing a character concept that has technical direction and has a nationalism vision. The research method used is integration-interconnection. Eighteen character values by the Ministry of Education are filled with tazkiyah al-nafs by Abū Hasan al-Nadwī which includes fiqh dhahir and fiqh bathin. The research findings produce tazkiyah al-nafs which includes shalat, fasting, zakat, sunnah worship, ‘ibadah bathin integrative with eighteen character concepts which include religious, honest, tolerant, discipline, active, creative, independent, democratic, curios, nationalist, patriotic, appreciative, friendship, peaceful, literative, environmentalist, humanist, and responsibilities.
Review Locally Tailored ELT Textbooks to Meet Primary Students’ Need: Textbooks Development
Authors: Ratri Devinta Puspita , Tyas Peptia Asrining
Published: October 2022

Since there is an emerging issue to strengthen students' local identity particularly in expanding circle countries in the midst of globalization, local culture integration in English language teaching (ELT) has lately grown to answer the challenge. Regarding the case, this study presents a textbook development with local culture integration in ELT for young learners as an effort to build students’ identity at early ages. It exposes that local culture integration can be inserted to all units in the textbooks for primary students which complement the theme-based curriculum as mentioned in the Ministry of Education and Culture Regulation No. 22 Year 2016. It implies that English textbooks with local culture integration may be modified as a viable and acceptable technique of addressing learners' local cultures while learning foreign language. Further, this textbook development provides current guidance for English teachers on how local culture integration in ELT might increase the energy, motivation, and reasoning for Indonesian young learners to learn English in a meaningful context.
Pengaruh Penambahan Sari Wortel (Daucus carota L.) Terhadap Sifat Fisikokimia Nata De Coco
Authors: Maradung Winda , Mandey Lucia C , Lamaega Jolanda , Pasang Patrik M
Published: October 2022

Tujuan dari penelitian ini adalah untuk mengetahui pengaruh konsentrasi penambahan sari wortel terhadap sifat fisikokimia nata de coco terhadap nata de coco. Metode dalam penelitian ini adalah Rancangan Acak Lengkap (RAL) yang terdiri dari 4 Perlakuan dan 3 ulangan dengan penambahan sari wortel berbeda tiap perlakuan dengan variasi perlakuan yakni 0%,10%,20% dan 30%. Parameter yang di uji adalah rendemen, ketebalan, warna, serat kasar, tekstur, kadar air dan kadar abu. Pada pengujian rendemen dan ketebalan dilakukan pengujian 12 unit percobaan. Pada pengujian warna, serat kasar, tekstur, kadar air dan kadar abu dilakukan pengujian 8 unit percobaan. Hal ini dikarenakan keterbatasan sampel yang dihasilkan setelah proses fermentasi. Hasil penelitian menunjukkan bahwa penambahan sari wortel terhadap sifat fisikokimia nata de coco menghasilkan rendemen berkisar antara 66,93-88,8%, ketebalan 0,86cm – 1,13cm, warna 50 – 56%, serat kasar 1,32–2,97%, tekstur 14kg – 19kg, kadar air 90,82-92,82%, kadar abu 0,34-0,36%.
Particle Swarm Optimization Setup for Hyperparameter Selection in Support Vector Machines
Authors: Restrepo-Uribe Juan , Sepulveda-Suescun Juan , Orrego-Metaute Diana , Urda-Benitez Robert , Escobar Juan Murillo
Published: October 2022

Selecting hyperparameters for support vector machines is an optimization task that affects their classification performance. In particular, particle swarm optimization has been successfully applied for this purpose; however, the literature in the field has not addressed the effect of the population topology and the method for handling constraints in the search space. In this paper, we assessed two population types (von Neumann and fully connected) and four methods for handling constraints in the search space (penalization, dynamic penalization, reflect, and border), for a total of eight different PSO setups. These PSO setups helped us to optimize an SVM using a radial basis function kernel, which means that two hyperparameters were selected: cost parameter (C) and kernel width (γ). We conducted the experiments over 10 benchmark classification problems and for atrial fibrillation detection. Our findings suggest that using a von Neumann population together with the reflect method provides the SVM with the best classification capabilities and shortest execution time.
Predictors of Research Subject retention - Repetitive non-adherence or socioeconomic factors: Insights from a urological clinical trial
Authors: Wheeler Allison J , GARG HARSHIT , KAUSHIK DHARAM , Mansour Ahmed , PRUTHI DEEPAK , LISS MICHAEL A
Published: October 2022

Background:
To investigate various patient level variables, specifically socioeconomic status, as risk factors for withdrawal in a recently completed clinical study. We specifically investigate a recent study in men on adherence to an observational prostate cancer imaging and biomarkers study.
Methods:
We performed a retrospective study to investigate risk factors for withdrawal in a prostate cancer imaging study that enrolled men on active surveillance from January 2016 to June 2019. For each subject, we assessed their retention status and collected demographic data. We compared values between the two retention groups using T-test, Chi-Squared, and logistic regression.
Results:
Out of 273 men screened, 123 men were enrolled and included in the results of this study. Of those, 106 (86%) were retained in the study and 17 (14%) were withdrawn. While we found no significant relationship between low socioeconomic status and retention, we did find that the number of non-adherences was a significant factor in withdrawal from the study (OR 2.5, 95% CI 3.5–40.5, p < 0.001).
Conclusions:
Expanding diverse inclusion and limiting withdrawal with real-time non-adherence monitoring will lead to more efficient clinical research and greater generalizability of results.
Clinical Outcomes of Octogenarian Patients with Upper Gastrointestinal Bleeding
Authors: İNAN OSMAN , ACEHAN MUHAMMED FATİH , ŞAHİNER ENES SEYDA , ASLAN MERYEM , ALTIPARMAK EMİN , ATES İHSAN
Published: October 2022

Background: This study aimed to reveal whether there is any difference in clinical outcome between the octogenarian (>80 years old) and non-octogenarian patients in the geriatric patient group (>65 years old) with acute upper gastrointestinal bleeding.
Methods: Patients aged 65 and over who were admitted with non-variceal upper gastrointestinal system bleeding included in the study. Patients in the study were divided into 2 groups, those aged 65-80 years and those over 80 years of age. Groups were compared in terms of laboratory findings, endoscopy findings, and serious clinical outcome.
Results: The number of patients included in the study was 263 and their mean age was 78.25 ± 8.20 years. Comorbidity was present in 97.4% of the patients and in both groups the most common comorbid disease was hypertension. 28.5% of the patients were taking anticoagulants, 39.9% were taking antiplatelet drugs, and 18.6% were taking non-steroidal anti-inflammatory drugs. The median hospital stay of the patients was 5 days. In-hospital mortality was 5 (4.4%) and 6 (4.0%) and rebleeding was seen in 10 (8.8%) and 13 (8.7%) patients in the octogenarian and non-octogenarian groups, respectively. The frequency of patients who stayed in the hospital longer than 21 days was significantly higher in the octogenarian group compared to the other group (p=0.011).
Conclusion: There was no significant difference in terms of in-hospital mortality, re-bleeding, need for intensive care, need for endoscopic intervention or hospital stay, but the frequency of prolonged hospital stay was significantly higher in the octogenarian group.
Sex-based differences in the lipidomic profile of circulating extracellular vesicles isolated from adolescents exposed to ethanol intoxication
Authors: Perpiñá-Clérigues Carla , Català-Senent José F. , Mellado Susana , Ibáñez Francesc , Costa Pilar , Marcos Miguel , Guerri Consuelo , García-García Francisco , Pascual Maria
Published: October 2022

Background Lipids represent essential components of extracellular vesicles (EVs), playing structural and regulatory functions during EV biogenesis, release, targeting, and cell uptake. Importantly, lipidic dysregulation has been linked to several disorders, including metabolic syndrome, inflammation, and neurological dysfunction. Our recent results demonstrated the involvement of plasma EV microRNAs as possible amplifiers and biomarkers of neuroinflammation and brain damage induced by ethanol intoxication during adolescence. Considering the possible role of EV lipids as regulatory molecules and biomarkers, we evaluated how acute ethanol intoxication differently affected the lipid composition of plasma EVs in male and female adolescents and explored the participation of the immune response. Methods Plasma EVs from humans, WT mice, and TLR4-KO mice were extracted. After the EVs lipids extraction and data acquisition by mass spectrometry, preprocessing and exploratory analyses were conducted. Experimental groups (ethanol and control groups of females and males) were compared from differential abundance analysis. Annotation of the lipids in their corresponding classes and a lipid set enrichment analysis were carried out to evaluate the biological function. Results We demonstrate for the first time that acute ethanol intoxication induces a higher enrichment of specific EV lipid species in human female adolescents (e.g., PA, LPC, unsaturated FA and FAHFA) than in males (e.g., PI). These lipid species participate in the formation, release, and uptake of EVs and the activation of the immune response. All data and results generated have been made openly available on a web-based platform (http://bioinfo.cipf.es/sal). Conclusions Our results suggest that female adolescents who binge drink alcohol also display increased levels of EV biogenesis and neuroinflammatory spread than males. Our findings also support the potential use of EV-enriched lipids as biomarkers of ethanol-induced neuroinflammation during adolescence.
Facile preparation of graphite nanosheets with excellent adsorption property
Authors: Cao Kesheng , Tian Zhengshan , Zhang Xunyou , Wang Yabo , Zhu Qiuxiang
Published: October 2022

Graphene and its derivative (graphene oxide, GO) have lots of important functional applications in various fields. At present, the improved Hummers’ methods are the most important preparation methods used to prepare GO nanosheets in scientific research and industrial preparation. Although many improvement measures of the Hummers’ method have been performed, and some problems still need to be solved. Herein, we develop a facile and green method to prepare nanosheets by exfoliating graphite powders in a dilute sulfuric acid (H2SO4) aqueous solution with hydrogen peroxide (H2O2) as oxidant, and subsequent ultrasonic treatment. The characterization results confirm that graphite nanosheets can be obtained with abundant oxygen-containing functional groups, similar to that of GO. Compared with the precursor, the obtained nanosheets have better adsorption performance, and can be used as adsorbent to remove methylene blue (50 mg/L) from water with removal efficiency of 95.0% and removal capacity of 23.8 mg/g, respectively. These nanosheets can also be used to remove Cd2+ (56.2 mg/L) with removal efficiency of 88.0% and removal capacity of 24.7 mg/g, respectively. The exfoliation mechanism has been analyzed and interpreted as strong oxygen attacking and subsequent ultrasonic stripping. This work provides an efficient preparation method of 2D graphite nanosheets for functional applications such as excellent adsorbent.
Observations of cold-induced vasodilation in persons with spinal cord injuries
Authors: Kamijo Yoshi-ichiro , Fujita Yasuhisa , Kinoshita Tokio , Hashizaki Takamasa , Murai Kota , Yoshikawa Tatsuya , Umemoto Yasunori , Kaminaka Chikako , Shibasaki Manabu , Tajima Fumihiro , Nishimura Yukihide
Published: October 2022

Study Design: Acute experimental study
Objectives: Cold-induced vasodilation (CIVD) is a local mechanism of protection against frostbite in able-body persons. This study assessed whether CIVD was observed in the sensate and non-sensate area in spinal cord injuries (SCIs) and whether the response patterns were different between the region levels or sites.
Setting: Laboratory of Wakayama Medical University, Japan
Methods: A local cooler device (diameter 4 cm) was placed on the chest (sensate) and thigh (non-sensate) in persons with cervical (SCIC; n=9) and thoracolumbar spinal cord injuries (SCITL; n=9). After the surface temperature was controlled at 33°C for 10 min (baseline), local cooling (LC) with a rate of 0.045°C/s was applied and the temperature was maintained at 15 and 8°C for 15 min of each stage. Skin blood flow (SkBF; laser Doppler flowmetry) was monitored using a 1-mm needle-type probe inserted into its center. CIVD was observed on the both sites in all participants at 8°C LC.
Results: % change in SkBF (%ΔSkBF) on the chest remained unchanged until the end of the 15°C stage in both groups, then it increased at 8°C stage over the baseline. %ΔSkBF on the thigh remained unchanged throughout the measurement in SCIC, but decreased during the periods from 33 to 15°C and from 15 to 8°C, then recovered to around the baseline level at 8°C in SCITL.
Conclusions: CIVD was observed both in the sensate and non-sensate areas in SCIs. The magnitudes of the response were different between the both areas.
WDR12 Facilitates Tumor Progression by Promoting Proliferation and Inhibiting Apoptosis in Colorectal Cancer
Authors: Wen Su , Huang Xueqing , Zeng Hao , An Kangli , Wu Shuang , Bai Jing , Yin Tiejun
Published: October 2022

Background: WD repeat domain 12 (WDR12) encodes a member of the WD-repeat protein family, a component of a nucleolar protein complex that affects the maturation of the large ribosomal subunit, which was highly expressed in colorectal cancer (CRC) tissues compared to para-cancerous tissues. However, its function is unclear in CRC. Thus, our goal was to reveal the biological role of WDR12 in the tumorigenesis and development of CRC.
Method：To investigate the correlation of gene knockdown with CRC malignancy (proliferative and anti-apoptotic) by performing lentivirus-assisted WDR12 knockdown experiments in HCT116 and SW620 model CRC cell lines and Validated in vivo experiments in nude mice. Then the possible mechanism of the downstream pathway of WDR12 was investigated by ingenuity pathway analysis (IPA). Finally, in vitro experiments explored the relationship between RAC1 and WDR12 in cell proliferation and anti-apoptosis.
Result: In-vitro lentivirus-assisted WDR12 gene knockdown experiments in CRC cell lines showed cell proliferation inhibition, decreased cell viability, and promotion of cell apoptosis compared to empty controls. Hereafter, In-vivo tumor formation experiments in nude mice revealed that tumor area, volume, and weight were significantly lower for knockdown WDR12. In addition, Ingenuity Pathway Analysis and Western blot showed that knockdown of WDR12 affected the down-regulation of a series of downstream genes, including RAC1, PLK1, EZH2, and SKP2, which affected cell proliferation, apoptosis, and cell cycle. Functional recovery experiments demonstrated that overexpression of RAC1 recovered the ability of WDR12 to promote cell proliferation and inhibit apoptosis.
Conclusion: In conclusion, WDR12 may be a novel oncogenic factor and a therapeutic target in CRC. Meanwhile, RAC1 may be one of the interacting genes in the downstream pathway of WDR12.
Transanal down-to-up dissection of the distal rectum as a viable approach to achieve total mesorectal excision in laparoscopic sphincter-preserving surgery for rectal cancer near the anus: A study of short- and long-term outcomes of 127 consecutive patients from a single Japanese institution
Authors: Kagami Satoru , Funahashi Kimihiko , Koda Takamaru , Ushigome Toshimitsu , Kaneko Tomoaki , Suzuki Takayuki , Miura Yasuyuki , Nagashima Yasuo , Yoshida Kimihiko , Kurihara Akiharu
Published: October 2022

Background
In rectal cancer (RC) surgery, the complexity of total mesorectal excision (TME) in laparoscopic sphincter-preserving surgery (lap-SPS) for RC near the anus has been a critical issue. Recently, technical assistance via the anus for complete TME has been receiving attention. This study aimed to clarify the transanal down-to-up dissection viability for achieving TME in lap-SPS for RC near the anus.
Methods
We evaluated surgical and oncological outcomes of a total of 127 consecutive patients undergoing either a transanal rectal dissection under direct vision (TARD) mobilizing the most difficult portion of TME via the anus or the transanal TME by using an endoscopic system (TaTME) for achieving TME in lap-SPS for RC near the anus between January 2006 and February 2021.
Results
A total of 127 consecutive patients (87 men), with a median age of 66 years (range 33–86 years), were included. TARD and TaTME were performed for 51 (40.2%) and for 76 (59.8%) patients, respectively. Preoperative treatment was performed for 41 (32.3%) patients, resulting in a complete pathological response in 5 (3.9%) patients. Intersphincteric resection was performed significantly in the TARD group (p < 0.001). Although the TaTME group needed a longer operative time at the transanal portion (p < 0.001), the median blood loss was inferior (p < 0.001). Postoperative complications of the Clavien–Dindo classification grade ≧ 2 developed in 56 (44.1%) patients. Urinary dysfunction (13.4%) was found most frequently, followed by stoma-related complications (12.6%). More patients needing medication for urinary dysfunction were found in the TARD group, but a significant difference was not observed (11.8% vs. 6.6%, p = 0.347). The quality of TME was good for almost all patients. Recurrence developed in 18 (14.2%) patients. The 5-year OS and DFS rates in 127 patients were 90.4% and 83.2%, respectively. The 5-year OS between the two groups was comparable, but the 5-year DFS in the TaTME group was significantly poorer (p = 0.024).
Conclusions
Our data suggested that a transanal down-to-up dissection of the distal rectum might be a viable approach in lap-SPS for RC near the anus. Further studies need to examine the differences between TARD and TaTME.
Life history of the predatory mites Amblyseius swirskii and Neoseiulus cucumeris (Acari: Phytoseiidae), candidates for biological control of the date palm mite, Oligonychus afrasiaticus (Acari: Tetranychidae)
Authors: Al-Alazzazy Mahmoud
Published: October 2022

The date palm mite, Oligonychus afrasiaticus (McGregor) (Acari: Tetranychidae), is a serious pest of dates in the Middle East and North Africa, inflicting severe economic damage if not controlled. As predaceous mites are known as potential biocontrol agents against several pests, predation capacity, life table, reproduction and survival of Amblyseius swirskii Athias-Henriot and Neoseiulus cucumeris (Oudemans) (Acari: Phytoseiidae), collected from date palm farms, were studied in a laboratory setting (25, 30, 35°C and 50 ± 5% RH) against all motile stages of O. afrasiaticus. For both predators, mean developmental time, oviposition period and longevity were inversely related to temperature from 25 to 35°C. The following parameters were obtained for A. swirskii and N. cucumeris at 25, 30 and 35°C, respectively: Female developmental time, 9.37, 7.29, 5.56, 10.67, 8.38, 6.45 d; oviposition period, 19.77, 16.18, 13.94, 15.90,13.84,10.64 d; longevity, 29.39, 24.79, 20.64, 25.42, 21.94, 17.39 d; fecundity, 31.91, 37.10, 42.16, 21.75, 26.84, 30.56 eggs per female. For both predators, the maximum daily predation rate was recorded at 35°C and occurred during the oviposition period. Total predation of A. swirskii and N. cucumeris female was 370.86, 387.54, 405.83, 232.14, 263.32, 248.85 prey at 25, 30 and 35°C, respectively. The maximum reproduction rate of A. swirskii and N. cucumeris (3.02, 2.87 eggs/♀/day) was recorded at 35°C while the minimum one (2.00, 1.36 eggs/♀/day,) was recorded at 25°C. Life table parameters were estimated as net reproductive rate (Ro) 21.68, 25.94, 29.52,18.95, 20.25, 22.78, Mean generation time (T) 24.92, 21.82, 18.24, 26.30, 23.60, 20.56 d, intrinsic rate of increase (rm) 0.181, 0.232, 0.248, 0.170, 0.185, 0.196, finite rate of increase (λ) 1.365, 1.551, 1.706, 1.126, 1.324, 1.428 for A. swirskii and N. cucumeris at 25, 30 and 35°C, respectively. The results of this study suggested that the two phytoseiid species are promising biological control agents of O. afrasiaticus at a wide range of temperatures.