bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic, prognostic, and predictive importance of neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial hyperplasia and carcinoma
Authors: Kumari Bharti , Haldar Debaditya , Singh Guddi R. , Kumari Sweta , Pankaj Sangeeta , Prasad Rajnikant
Published: July 2024

Background:

Inflammation has an important role in the progression of endometrial carcinoma.

Aims:

The aim of this study is to find the association between neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), and CA125 in endometrial hyperplasia and endometrial carcinoma. The study also focuses on the association of CA125, NLR, and PLR with histopathological parameters in endometrial carcinoma that are of prognostic importance.

Materials and Methods:

This is a prospective cross-sectional study on 57 biopsy-proven cases of endometrial hyperplasia and carcinoma conducted over a period of two years. The NLR, PLR, and CA125 were calculated and recorded in all the 57 cases.

Results:

The 57 cases were divided into three groups: endometrial hyperplasia without atypia group which included 36 cases, endometrial atypical hyperplasia group which included 10 cases, and the endometrial carcinoma group which included 11 cases. Comparison was done between the groups, and parity, NLR, PLR, and CA125 were found to be significant, but patient age and postmenopausal status were not significant. NLR, PLR, and CA125 were found to increase with higher grade, pT-stage, and nodal stage for the endometrial carcinoma cases.

Conclusion:

NLR, PLR, and CA125 were marginally increased or normal in the case of endometrial hyperplasia without atypia and endometrial atypical hyperplasia, while they were significantly increased in endometrial carcinoma, and also correlated with an increase in grade, pT-stage, and nodal stage. Hence, these can be considered for additional screening as diagnostic, prognostic, and predictive markers in case of abnormal uterine bleeding with endometrial pathology.
GLUT1 and ASCT2 expression and their prognostic value in colorectal carcinoma
Authors: Ibrahiem Afaf T. , Refat Sherine , Elnaghi Khaled , Emarah Ziad , Nagib Reham Mohamed
Published: July 2024

Background:

Investigation of new molecular markers expressed in colorectal carcinoma can help to select patients getting benefits from new target therapeutic modalities.

Aim:

Investigation of expression of GLUT1 and ASCT2 in colorectal carcinoma.

Materials and Methods:

Sixty three colorectal resection specimens for cases diagnosed with colorectal carcinoma were included in the study. Full sections were examined for histopathological data including tumor type, grade, stage, and lymphovascular invasion were recorded. TMA blocks were constructed and immunostained with polyclonal antibodies for both GLUT1 and ASCT2.

Results:

GLUT1 was expressed in 82% of cases while ASCT2 was expressed in 76% of cases. Statistically significant correlation was found between both GLUT1 and ASCT2. A statistically significant correlation was found between either marker with both disease stage and lymph node metastases. No significant correlation was found between either GLUT1 or ASCT2 and any of the clinical parameters as well as with disease-free survival.

Conclusion:

GLUT1 and ASCT2 are more prevalent in poorly differentiated and advanced stage colorectal carcinoma. Their expression in high percentage of cases can suggest the possible role of their target therapies in colorectal carcinoma.
Delayed Presentation of Intradural Extramedullary Tuberculoma of Spine in an Immunocompetent MDR-TB Patient
Authors: Saurabh Nishant , Nallathambi Vetri
Published: July 2024

Intradural spinal tuberculoma is a rare entity, constituting <5% of CNS tuberculoma, whereas intradural extramedullary tuberculoma of spinal cord (IETSC) is even less frequently encountered. Here, we report a case of IETSC at two noncontiguous levels in spinal cord presenting with compressive myelopathy in a patient on multidrug-resistant tuberculosis (MDR-TB) treatment. Surgical decompression and appropriate ATT regimen resulted in gradual return to near-normal neurological function with no functional disability. To our knowledge, this is the first case report of IETSC developing in an immunocompetent patient on MDR regimen for drug resistant sputum-positive pulmonary tuberculosis.
Can Frailty Predict 90-Day Postoperative Outcome in Elderly Patients with Degenerative Cervical Spine Pathology?
Authors: Chatterjee Sourav , Dalvie Samir , Monteiro Joseph N. , Parihar Rohan , Kumar Pawan , Chakrawarthi Dileepan , Chaudhary Kshitij R.
Published: July 2024

Background:

Age and general health status are major points of concern in the decision-making process when it comes to cervical spine surgeries in the elderly. While there have been studies on the various frailty indices in their ability to predict outcomes in spine surgery, there have been few articles that have investigated the utility of the 5-point modified Frailty Index (mFI-5) for this purpose. Our study attempts to have a granular view of the problem of frailty in the elderly and study the correlation between the mFI-5 and American society of anesthesiologists (ASA) classes, and the 90-day surgical outcome of patients of 60 years and above, operated for degenerative cervical spine pathologies.

Materials and Methods:

This is a single-center retrospective study of prospectively collected data on 41 patients aged 60 years and above who were operated at our institute between January 1, 2017, and December 31, 2022. We studied the correlation of mFI-5, ASA class and the Spinal Surgical Invasiveness Index (SII) with various outcome variables like length of hospital stay, need for ICU stay, complications, severe adverse events (Clavien Dindo grade 4 and above), re-intubation, unplanned re-admission, and need for re-operation.

Results:

Statistical analysis showed a significant correlation between ASA class and mFI-5 scores (Chi square test, P value: 0.0401) and between ASA scores and the need for an ICU stay (Chi square test, P value: 0.0047). SII was found to correlate with length of hospital stay (Spearman rank test, P value: 0.0037) and with need for ICU care (Mann–Whitney U test, P value 0.0422). However, there was no significant correlation between the mFI-5 scores and the outcome variables.

Conclusion:

Although there was no significant correlation between mFI-5 and the 90-day surgical outcome, variables like ASA and SII had a bearing on it. Thus, it can be stated that the outcome of cervical spine surgery in the elderly is multifactorial. While frailty should put the healthcare team on alert while dealing with such patients, it should not discourage them from offering a surgical solution when required, as efficient peri-operative management by the surgical, anesthesia, and critical care teams can lead to favorable 90-day outcomes.
Monitoring Transcranial Motor-Evoked Potentials in Charcot–Marie–Tooth Disease: A Case Report
Authors: Ajmal Muhammed , Pavithran Priyanka , Sudarshan Pramod
Published: July 2024

Charcot–Marie–Tooth (CMT) disease, the most common inherited neuropathy, is the most common neuromuscular disorder. It is associated with several orthopedic deformities. Neurophysiological monitoring during scoliosis surgery in these patients can be challenging due to baseline neurological abnormalities. Intraoperative neuromonitoring (IONM) provides vigilance against postoperative neurological deficits. Literature searches have revealed case reports and studies demonstrating difficulties in obtaining IONM potentials in these patients. This case report shares our experience with IONM using transcranial motor-evoked potentials in a case of CMT disease.
The Application of Spinal Manipulation Results in Alterations in Thalamic Neural Metabolite among Patients Experiencing Nonspecific Chronic Low Back Pain
Authors: Didehdar Daryoush , Kharazinejad Ameneh
Published: July 2024

Background:

In patients diagnosed with nonspecific chronic low back pain (NCLBP), discernable discrepancies in pain perception have been observed. This study endeavors to assess alterations in left thalamic metabolites in patients with NCLBP following spinal manipulation, utilizing proton magnetic resonance spectroscopy (1H-MRS).

Materials and Methods:

A total of 16 individuals diagnosed with NCLBP and 16 healthy individuals volunteers of normal constitution (aged between 20 and 50 years) were recruited. All participants exhibited right-hand dominance. Before commencement of therapeutic intervention and at a 5-week interval thereafter, functional and radiological assessments were undertaken (Oswestry Disability Index, numerical rating scale, and 1H-MRS). The values were compared using independent and paired t tests.

Results:

Following spinal manipulation, the patients experienced notable reductions in pain and disability (P < 0.05). The treatment group demonstrated significant increases in N-acetyl aspartate (NAA), choline (Cho), myo-inositol (Mio), and glutamate and glutamine (Glx) in the left thalamus region post-treatment compared with the baseline measures (P < 0.05). Before treatment, NAA, Cho, Glx, and Mio levels were significantly lower in the left thalamus of the patients compared with healthy subjects (P < 0.05). However, no significant differences in terms of metabolites were observed between the healthy control group and the patients after the treatment.

Conclusion:

In patients presenting with NCLBP, spinal manipulation has been observed to exert an effect on the brain, thereby inducing changes in thalamic metabolites.
Spinal Injuries Due to Falls from Height
Authors: Gnanaprakash G , Peddireddy Sreeharsha , Kanna Rishi Mugesh , Shetty Ajoy Prasad , Rajasekaran S.
Published: July 2024

Background:

Traumatic spinal injuries (TSIs) due to falls from heights are characterized by unique injury mechanisms, morphological features, and severity. In this study, we conducted an analysis of the epidemiological, clinical, and radiological data of TSI patients caused by falls from heights. We compared these findings with those of patients injured by other mechanisms.

Materials and Methods:

During a five-year period (2015–2019), all patients with traumatic spinal injuries who received treatment at a tertiary-level trauma center were categorized into two groups: those injured by falls from height (group 1) and those injured by other modes (group 2). Their medical records were reviewed for analysis.

Results:

Falls from height (group 1) constituted the predominant cause of TSI, affecting 51.8% (1069/2065) of spine trauma patients. The average age in group 1 (44.45 ± 16.76) was significantly higher than in group 2 (42.33 ± 15.81) (P = 0.003). In group 1, the most common level of injury was the lumbar spine (48.6%, n = 520), whereas in group 2, it was the cervical spine (48%, n = 478). Multiple levels of injury were more common in group 1 than in group 2 (25.2% vs. 19.2%, P = 0.002). The most common type of spine injury was AO type B in group 1 (35.43%, n = 377) and AO type C in group 2 (32%, n = 319). Other associated organ system injuries were significantly higher in group 2 than in group 1 (P < 0.05), except for pelvic injuries. Additionally, spinal injury-related complications were higher in group 2 (16.7%) than in group 1 (11.6%) (P = 0.001). The length of hospital stay was significantly higher in group 2 (9.71 ± 9.03 days) compared to group 1 (8.09 ± 7.26 days).

Conclusion:

Our study has revealed significant demographic and epidemiological variances in TSI caused by falls from heights compared to other injury mechanisms. This information is crucial in understanding the mechanism and injury pattern in TSI due to falls from height, as well as for formulating effective management strategies.
Assessing the Accuracy of Ultrasonography and Biopsy Necessity in the Management of Breast Lumps in Women Less than 40 Years
Authors: Itanyi Ukamaka Dorothy , Chukwuegbo James Nwabueze , Okafor Ugochukwu Egbunike , Richard Samuel Kelechi , Yawe King-David Terna
Published: July 2024

Background:

Following recommended guidelines, palpable breast lumps in young women should be subjected to clinical–radiologic evaluation and tissue diagnosis where necessary. However, in our local practice, most benign breast lumps are also subjected to excision biopsy. Ultrasonography is the modality of choice in the evaluation of palpable breast lumps in young women.

Aim:

This study aims to determine the accuracy of ultrasonography and the necessity of tissue biopsy in the management of palpable breast lumps in women less than 40 years of age and to determine lesions that can safely be managed conservatively based on histological diagnosis.

Materials and Methods:

This was a prospective cross-sectional study of 87 adult females who had breast US and biopsy for palpable breast lumps in a tertiary healthcare center over a period of 10 months (July 2020–May 2021).

Results:

The age range of the women was 18–39 years (mean 27.9 ± 7.09 years).

Benign lesions were noted in 86.2% of patients. No malignancy was detected in women < 25 years. Ultrasonography had sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of 100%, 93.4%, 70.6%, 100%, and 94.3%, respectively, in differentiating benign from malignant breast lumps following tissue diagnosis.

Conclusion:

Ultrasonography and tissue biopsy are vital in the evaluation of breast lumps in women less than 40 years of age. Most (86.2%) of the lumps were benign, and no malignancy was detected in women < 25 years. The high accuracy of ultrasonography in distinguishing benign from malignant lesions suggests the need for conservative management of benign lumps in young women.
Assessment of Body Image Perception and Quality of Life of Breast Cancer Patients Accessing Care at the University College Hospital, Southwest Nigeria
Authors: Sarimiye F , Folasire A , Asuzu CC
Published: July 2024

Background:

Breast cancer is the most prevalent cancer type globally. The female breasts are important for beauty and sexuality, comprising the body image, which includes the individual self-perception and others. This varied perception may influence the quality of life of individuals with breast cancer.

Aim:

To assess the body image perception and quality of life of breast cancer patients accessing care at the University College Hospital Ibadan.

Methods:

Eligible female adults (18 years and above), with a confirmed histologic diagnosis of breast cancer participated in this study after obtaining informed consent. The participants were without other debilitating conditions and had access to care for at least 12 months. We used a questionnaire to collect information on body image perception and quality of life (QoL) from all the participants. Data were analyzed using descriptive and inferential statistics.

Results:

One hundred sixty (160) female participants were recruited, with 74.38% having been diagnosed with breast cancer for 3 years or more, and 84.38% of them detected abnormality during breast self-examination. Over 50% of the participants had negative body image perceptions. Educational level, social/family well-being, and physical well-being were significantly associated with the QoL. There was a three-fold increase in the social and family well-being subscale score among participants with higher education levels.

Conclusion:

Negative body image results in poorer QoL in breast cancer patients, and this underscores the importance of addressing body image concerns as part of comprehensive care for breast cancer patients.
Predictors of Time to Return to Work Following Surgical Reconstruction of Upper Limb Injuries in a Cosmopolitan City in Western Nigeria
Authors: Michael AI , Isamah CP , Ugwu IC
Published: July 2024

Background:

The management of upper limb injury is aimed at a timely return to work, and other activities of daily living. The modified hand injury severity score (MHISS) has been found to predict a return to work. Upper limb injuries are common in our subregion, but there is little or no data on the time to return to work.

Aim:

This study, therefore, aimed to determine the prevalence of return to work and to identify the predictors of time to return to work following reconstruction of upper limb injuries.

Method:

This was a cross-sectional analytic study carried out between April 2022 and March 2023. The statistical test was at a confidence interval of 95%, and statistical significance set at a P value of <0.05.

Result:

A total of 49 upper-limb-injured patients had reconstruction in the time under review. Male-to-female ratio was 4.4:1. The mean MHISS was 87.9 ± 79.2. Of the 43 patients who participated in the return-to-work analysis, 41.9% had returned to work, with a mean time of 14.3 ± 10.5 weeks. Work-related injuries (r = 0.357, P = 0.019), male gender (r = 0.354, P = 0.020), and MHISS (r = 0.333, P = 0.029) correlated significantly with late return to work. On multiple logistic regression, work-related injuries (β =0.321, P = 0.037), MHISS (β =0.376, P = 0.032), and male gender (β =0.326, P = 0.044) were found to be the significant predictors of late return to work.

Conclusion:

There is a low prevalence of return to work, with a high mean time to return. Work-related injuries, MHISS, and male gender are significant predictors of time to return to work.
Fucoidan Inhibits Prostate Cancer Growth Through Modulation of Different Cell Deaths
Authors: Tutuncu M , Sanlav G , Aktaş S , Yilmaz O , Altun ZS
Published: July 2024

Background:

Docetaxel (DOC) is the main chemotherapeutic agent for the treatment of advanced metastatic prostate cancer. Docetaxel shows anticancer effects by preventing the depolymerization of microtubules in the cell, therefore preventing cell division. However, the low survival effect of docetaxel has prompted researchers to search for novel therapeutic agents. Fucoidan (FUC) is a sulfated polysaccharide derived from brown algae. It has many bioactivities which makes fucoidan a promising anticancer agent. In this study, the potential anti-tumorigenic and preventive effects of fucoidan with or without docetaxel in prostate cancer were investigated by analyzing different cell death modalities.

Methods:

The in-vivo six groups (n = 8) were conducted; preventive (Pt), docetaxel treated after preventive (Pt-D), control, fucoidan (FUC), docetaxel (DOC), and FUC and DOC (FUC+DOC) combination. Apoptotic, necroptotic, and autophagic cell death-related protein expressions were assessed in tumor tissues by using immunohistochemical staining. Oxidative stress-related lipid peroxidation, glutathione peroxidase, and glutathione levels were also determined in tumor tissues.

Results:

Although apoptotic, necroptotic, and autophagic cell deaths were significantly induced in agent-treated groups compared to the control. Apoptotic cell death was more significantly induced in FUC and FUC+DOC-treated groups. Necroptotic cell death was increased considerably by inducing MLKL protein expression in all treatment groups. In the FUC, Pt, and DOC groups, LC3A/B expressions were significantly increased. DOC, FUC+DOC, and Pt-D treatments caused a significant increase in Beclin-1 expression. Oxidative stress-related MDA, GPX, and GSH levels significantly decreased with FUC treatment. The anti-tumorigenic effects of FUC and DOC were also demonstrated through tumor size reduction.

Conclusion:

According to the findings of this study, FUC inhibited tumor growth temporally and dimensionally, especially in preventive applications. FUC and FUC+DOC combinations in both treatment groups showed anti-tumorigenic effects. The results of this study suggest that fucoidan is a promising anticancer agent against prostate cancer. FUC can be considered as a preventive or treatment agent in prostate cancer therapy with DOC. Further studies are needed to fully elucidate the mechanism of action of fucoidan in metastatic prostate cancer.
Giant Common Peroneal Nerve Schwannoma Mimicking Synovial Sarcoma: An Unusual Case Report
Authors: Tamulionis P , Ostapenko E , Šeinin D , Kilius A
Published: July 2024

Schwannoma, also known as neurilemmoma or Schwann cell tumor, is one of the most common neoplasms of the nerve sheath which usually appears at the head, neck, or upper extremity. Schwannoma occurrence in the lower extremity originating from the common peroneal nerve is rarely reported according to literary findings. We report a case of a 32-year-old man who presented with a 6-month history of a growing lump in the left knee. MRT revealed a well-defined 9.6 cm × 7.8 cm × 6.5 cm multilobular mass of heterogeneous consistency with areas of necroses with a likely diagnosis of synovial sarcoma. After surgery, a final histopathological assessment of the tumor demonstrated Antoni A and B patterns with nuclear palisading, hallmarks of a schwannoma. Postoperatively the patient suffered a neurological complication–impaired dorsiflexion of the left foot. The patient started immediate physiotherapy in the Department of Rehabilitation. Three weeks after the operation, gradual improvement in neurological function was observed. To date, complete tumor excision combined with microscopic analysis and immunohistochemical staining remains the gold standard in diagnosing and treating a peripheral nerve schwannoma. Moreover, the use of additional nerve monitoring tools during surgery could help to prevent complications.
Prevalence and Pattern of Tooth Impaction: A Radiographic Study in a Trinidadian Population
Authors: Naraynsingh CN , Henry K , Hunte R , Ramlogan N , Bissoon A
Published: July 2024

Objective:

The aim of this retrospective study was to determine the prevalence and patterns of impacted third molars in a Trinidadian population.

Methods:

A total of 1500 orthopantomograms (OPG) taken at the School of Dentistry, University of the West Indies, from 2008 to 2019 in patients between 15 and 67 years old were evaluated. From the data collected, the prevalence of third molar impaction, the parameters of gender, angulation, level of impaction, and associated pathologies were evaluated. Other types of impacted teeth were also recorded.

Results:

Of the 1500 OPG viewed, 408 (27.2%) of the study sample presented with at least one impacted third molar. 161 (39.5%) were males and 247 (60.5%) were females, with a male-to-female ratio of 1:1.5. There was a greater incidence of mandibular third molars versus maxillary third molars, which had a frequency of 77.9% and 22.1%, respectively. The most common type of impaction (Winter’s classification) was horizontal in the mandible and distoangular in the maxilla. The most common level of impaction in the mandible (Pell and Gregory classification) was level 1A. The total number of impacted teeth was 775, and of these, 75 (9.7%) showed other impacted teeth besides the third molars. Canines and second premolars were the most prevalent with 7.6% and 1.5%, respectively. Caries on the second molar (49.3%) and third molars (40%) were the most frequently associated pathologies identified.

Conclusion:

The prevalence of impacted wisdom teeth in this study was 27%. These results raise awareness and provide insight among dental professionals in Trinidad as to the prevalence of impacted third molars, their patterns, as well as commonly associated pathologies, and the need for screening within the population.
Granulomatosis with Polyangiitis: A Rare but Clinically Important Disease for the Otolaryngologist
Authors: Webb H , Toppi J , Fairley J , Phillips D
Published: July 2024

Introduction:

Granulomatosis with polyangiitis (GPA) is rare but debilitating autoimmune disease and commonly presents with sinonasal as well as other head and neck symptoms.

Aims:

To summarize the ear, nose, and throat-specific symptomatology and management of GPA.

Methods and Results:

We performed a literature review by using the PubMed search engine to provide a summary of recent and important literature that is pertinent to an otolaryngologist’s clinical practice. We provide a guide on the pathophysiology, epidemiology, clinical features, investigation, and management (operative and nonoperative) of this important disease.

Conclusions:

This review illustrates the important role that an otolaryngologist can play in the work up and symptom management of patients with GPA. Knowledge of the common presenting symptoms as well as more rare presentations of GPA is extremely important for otolaryngologists as prompt diagnosis and management is extremely important to avoid significant morbidity and mortality.
Titanium Alloy Bars, Forgings, and Forging Stock, 7.0Al - 4.0Mo, Annealed
Authors:   AMS G Titanium and Refractory Metals Committee
Published: July 2024

This specification covers a titanium alloy in the form of bars up through 6.000 inches (152.40 mm), inclusive, in nominal diameter or least distance between parallel sides, forgings of thickness up through 6.000 inches (152.40 mm), inclusive, and stock for forging of any size (see 8.6).
Analyzing the Relationships between State School Policies and Absenteeism Rates for 9-12th Grade Students in Texas-Mexico Border Districts
Authors: Gallegos Gabriela Angelina , Schaper Kylie , Roy Sharmily , Gao Jingjing
Published: July 2024

Chronic absenteeism can impact high school students’ long- and short-term development, especially in socio-economically challenged areas such as the Texas-Mexico border. We aimed to identify effective public school absenteeism policies and provide a roadmap for further investigation and state policy advocacy. This study analyzed four district-level school absenteeism policies in 88 public school districts along the Texas-Mexico border:  requiring parental notification after one absence, offering incentives for student attendance, assignment of a Truancy Prevention Facilitator, and punishing students for absenteeism.  District policies were collected through a review of district websites, student handbooks, codes of conduct, District Improvement Plans, and District of Innovation Plans. The chronic absenteeism and emergent bilingual/English learner (EB/EL) absenteeism rates reported in Texas Education Agency Texas Academic Performance Reports for grades 9-12 were utilized as attendance indicators. Hierarchical linear modeling, an ordinary least square regression-based analysis, was used to examine association relationships between the policies as independent variables and absenteeism rates as the dependent variables. School districts that do not offer attendance incentives and assign officers as truancy prevention facilitators have the highest predicted total chronic absenteeism rate; districts that do not offer attendance incentives and assign support services personnel as truancy prevention facilitators have the highest predicted EB/EL absenteeism rate. Districts with attendance incentives also are associated with higher EB/EL absenteeism. Identifying effective school policies to reduce chronic absenteeism will help districts better tailor the implementation of state policies and promote access to education and services.
Strategi Bimbingan Belajar new Primagama Karawang Pasca Pandemi Covid-19
Authors: Sabrina Putri Aulia
Published: July 2024

Strategi adalah hal yang penting untuk mencapai tujuan pendidikan. Pelaksanaan pendidikan di Indonesia selama dua tahun kebelakang mengalami hambatan karena adanya Pandemi Covid-19. Kementrian Pendidikan Indonesia mengeluarkan kebijakan yaitu dengan meliburkan sekolah dan mengganti proses Kegiatan Belajar Mengajar (KBM) dengan menggunakan sistem dalam jaringan (daring). Namun pada saat ini, kasus pandemi covid-19 mengalami penurunan serta pelonggaran sehingga beberapa sekolah sudah ada yang melakukan pembelajaran tatap muka. Hal ini akan mempengaruhi proses pembelajaran pendidikan formal maupun non formal. Para pendidik harus mengkaji ulang terkait strategi pembelajaran yang akan diterapkan pasca pandemi Covid-19. Dalam hal ini layanan bimbingan belajar menjadi bagian terpenting bagi peserta didik, mengingat pada saat ini peserta didik dituntut untuk bisa berkompetensi. Penelitian ini menggunakan metode kualitatif dengan hasil bahwa layanan bimbingan belajar New Primagama Karawang menerapkan strategi yang berpusat pada pendidik dan strategi interaktif yang memungkinkan diskusi antara peserta didik dan pendidik. Menggunakan metode hybrid-learning, serta memiliki teknik unggulan yakni two-teachers models, dimana para peserta didik diberikan dua jenis pendidik yaitu secara online/daring dan juga dibimbing langsung ditempat. Kedua pendidik tersebut memiliki tujuan pembelajaran yang sama
Program Pendaftaran Tanah Sistematis Lengkap (PTSL) Oleh Badan Pertanahan Nasional di Surabaya
Authors: Putri Rahmadani Lisa
Published: July 2024

Pelaksanaan pendaftaran tanah di tiap-tiap daerah merupakan tanggung jawab besar pemerintah yang menjelaskan salah satunya kegunaan sertifikat tanah, yaitu untuk memberikan kepastian hukum dan perlindungan hukum kepada pemegang hak atas suatu bidang tanah, satuan rumah susun dan hakhak lain yang terdaftar agar dengan mudah dapat membuktikan dirinya sebagai pemegang hak yang bersangkutan. Tujuan penelitian untuk mengetahui dan menganalisis Program Pendaftaran Tanah Sistematis Lengkap (PTSL) oleh Kantor Badan Pertanahan Nasional Kota Surabaya dan manfaat yang terjadi. Program Pendaftaran Tanah Sistematik lengkap (PTSL) oleh Kantor Badan Pertanahan Nasional Kota Surabaya, sudah dilaksanakan namun belum berjalan dengan optimal. Adapun hambatan yang belum sesuai dengan pelaksanaannya seperti belum tercapainya tujuan dalam pencapaian target Sertifikat Hak Atas Tanah (SHAT) karena banyak pemohon yang belum terdaftar, terlambatnya permberkasan yang mengakibatkan tujuan kebijakan dalam proses pencapaian target Sertifikat Hak Atas Tanah (SHAT), kurangnya fasilitas untuk pelaksanaan pendaftaran, kurangnya komunikasi antara kantor BPN dan masyarakat yang kurang paham mengenai adanya program PTSL, adanya lingkungan yang kurang kondusif yaitu tidak hadirnya masyarakat saat proses pengukuran. Untuk mengatasi hambatan tersebut, yaitu dengan mengaktivasikan NIK yang tidak valid agar dapat mengajuakan pemberkasan untuk pendaftaran program PTSL, mengoptimalkan proses pemberkasan dari pihak Desa agar pengentrian oleh staf kantor BPN bisa segera dilakukan dan cepat selesai.
Hubungan Kadar Glukosa Darah Puasa dengan Kadar Trigliserida dalam Darah
Authors: Christyawardani Lidwina Septie , Haiti Margareta
Published: July 2024

Kadar glukosa darah yang tinggi memiliki potensi mengganggu metabolisme lipid dengan mengakibatkan peningkatan tingkat kolesterol total, trigliserida (TG), low density lipoprotein (LDL), dan penurunan high density lipoprotein (HDL). Jika tingkat trigliserida dalam aliran darah terus meningkat, ini disebut hipertrigliserida, dan ini dapat menyebabkan aterosklerosis. Penelitian ini bertujuan untuk mengetahui bagaimana kadar glukosa darah dan tingkat trigliserida dalam aliran darah berhubungan satu sama lain. Peneliti melihat dan menganalisis pengaruh variabel independen terhadap variabel dependen dalam penelitian ini. Jenis penelitian yang digunakan adalah desain observasional analitik dimana sampel yang digunakan adalah mahasiswa D IV Teknologi Laboratorium Medis Fakultas Ilmu Kesehatan UKMC. Data yang diperoleh dianalisis menggunakan uji korelasi spearmen’rho Tidak ada korelasi yang signifikan antara kedua variabel yang diteliti, seperti yang ditunjukkan oleh analisis hubungan antara konsentrasi glukosa dalam darah dan trigliserida, dengan nilai p=0,842. Penelitian ini menunjukkan bahwa tidak ada korelasi yang signifikan antara variabel.
Specific antitumor activity of anti-CA125 CAR-T lymphocytes against CA125-positive and CA125-negative cells
Authors: Kulinich T. M. , Kiseleva Ya. Yu. , Shishkin A. M. , Kudinova E. A. , Knyazeva O. B. , Ranjit R. , Bozhenko V. K. , Solodky V. A.
Published: July 2024

Aim. To evaluate the antitumor efficacy of our developed drug based on cytotoxic T lymphocytes genetically modified with a chimeric antigen receptor (CAR) specific to the CA125 antigen in relation to both CA125-positive and CA125negative cell cultures.

Materials and methods. We performed an in vitro study on CA125-positive human ovarian cancer cells (OVCAR-3, OVKATE) and CA125 negative cells (breast cancer MCF 7, embryonic kidney HEK293). Cytotoxic effects on tumor cells were evaluated after 0, 4, 8 and 24 hours using the 3’-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) and Lactate Dehydrogenase (LDH) tests. We also studied the changes in the number of cells “in real time” when exposed to transfected lymphocytes using the RTCA iCELLIgence device (ACEA Biosciences, USA). Lymphokineactivated killer (LAK) cells were used as a specificity control.

Results. The study demonstrated that anti-CA125 CAR-T lymphocytes exhibited a pronounced cytotoxic effect on OVCAR-3 and OVKATE cell cultures, exceeding the effect of LAK by 1.3 times. The cell population in the experimental samples decreased by 70 ± 4%, which exceeded the LAK effect by 9 ±  8.2%. With regard to the MCF-7 cell line, the cytotoxic effect of anti-CA125 CAR-T lymphocytes was minimal as evidenced by a 25.8% decrease in the relative number of live cells in comparison to the LAK cytotoxicity of 68%. Real-time monitoring of cell proliferation and viability proved a high specific cytotoxic effect of anti-CA125 CAR-T lymphocytes against tumor cultures expressing CA-125, while inferior to LAK in cultures not expressing CA125 (MCF-7, HEK293).

Conclusions. The use of anti-CA125 CAR-T lymphocytes against CA125-positive tumor cell lines OVCAR-3 and OVKATE demonstrated a pronounced specific cytotoxic effect exceeding the cytotoxic effect of LAK, which was not achieved against CA125-negative MCF-7 and HEK293 cells.
Fatty acid composition of blood serum and erythrocyte membranes in men with steatosis and steatohepatitis with normal transaminase activity
Authors: Kruchinina M. V. , Osipenko M. F. , Shestov A. A. , Parulikova M. V.
Published: July 2024

Aim. To study the characteristics of the fatty acid (FA) profi le of blood serum and erythrocyte membranes in patients with two forms of fatty liver disease (metabolic + alcoholic): steatosis and steatohepatitis with normal transaminase activity.

Materials and methods. We examined 33 men (50.7 ± 9.6 years) with fatty liver disease (metabolic and alcoholic) with fi brosis F ≤ 1 (FibroTest). According to the ActiTest results, patients were divided into groups of steatosis – with minimal (A0–1) activity (n = 17) and steatohepatitis – with moderate/severe (A2–3) necroinfl ammatory activity (n = 16). The FA composition of blood serum and erythrocyte membranes was studied using gas chromatography/mass spectrometry Agilent 7000B (Agilent Technologies, Inc., USA). Methods of unpaired statistics using volcano plot and discriminant analysis based on orthogonal least squares (Orthogonal Partial Least Squares Discriminant Analysis, OPLS-DA), ROC analysis were applied.

Results. Volcano plot analysis showed that in patients with fatty liver disease (metabolic and alcoholic) with normal transaminase activity, serum levels of stearic C18:0 (p = 0.016), arachidic C20:0 (p = 0.023), ratio saturated / polyunsaturated fatty acids (PUFA) (p = 0.001) were statistically signifi cantly higher in the steatohepatitis group compared with the steatosis group. The total content in the blood serum of all PUFA (p = 0.003), margaric C17:0 (p = 0.011), the sum of two omega-3 PUFA – eicosapentaenoic acid (C20:5n-3) and docosahexaenoic acid (C22:6n-3) (p = 0.04), the total content of all omega-3 PUFA (p = 0.042) were statistically signifi cantly lower in patients with steatohepatitis. OPLS-DA demonstrated fairly accurate separation of steatohepatitis and steatosis using individual FA and their ratios. When individual FA and their ratios were included in the analysis, a model was obtained with AUC = 0.827 (95% confi dence interval 0.499–1.0), sensitivity 82.2% and specifi city 80.7%.

Conclusion. FA in blood serum and erythrocyte membranes appear to be promising biomarkers of steatohepatitis with normal levels of transaminases.
Academic Supervision through Coaching Techniques to Enhance Teachers’ Professional Competence
Authors: Mubinan Fathan ,   Student of Jakarta State University, Jakarta, Indonesia, Fuad Nurhattati , Sari Eliana ,   Lecturer of Jakarta State University, Jakarta, Indonesia,   Lecturer of Jakarta State University, Jakarta, Indonesia
Published: July 2024

This study aims to understand how coaching techniques can be used in supervision to enhance teachers’ professional competence. The subjects involved in this research are school principals, teachers, and human resources managers from educational foundations. The research instruments used include observation and interviews. The analysis results indicate that academic supervision using coaching techniques helps school principals understand real-time data on teachers’ conditions and competencies, allowing for targeted follow-up programs designed by the school principal. Based on this, it can be concluded that coaching techniques are essential in academic supervision.
Exploring the Mediating Effect of Social Media Perception on Green Beauty Products Purchase Intention: The Evidence from Indonesia
Authors: Ratri Dewi Bernadeta ,   International MBA. National Tsing Hua University, Taiwan
Published: July 2024

Amidst the growing beauty industry in Indonesia, several local beauty brands have embraced the theme of sustainable beauty or produced environmentally friendly beauty products to reduce pollution impact and pay closer attention to the ingredients used. This research aims to analyze the factors influencing consumers to purchase environmentally friendly beauty products. Based on quantitative data processing using SMART PLS, it was found that there are two main factors that influence consumers' considerations to purchase environmentally friendly beauty products, namely green product knowledge and green perceived value. Furthermore, the perception of social media also mediates the relationship between green product knowledge and green perceived quality towards green beauty products purchase intention. Thus, eco-friendly beauty companies can effectively communicate their environmentally friendly attributes and product value propositions, thereby shaping consumer behavior towards more sustainable choices.
The Viability of Quick Service Restaurant (QSR) in the Township Market: A Fast Food Industry Case in South Africa (SA)
Authors: P Maharaj ,   Regent Business School, Johannesburg, South Africa, L Mtsweni ,   University of South Africa, Janadel street, Midrand 1686 South Africa
Published: July 2024

This study aimed to explore the viability of a Quick Service Restaurant (QSR) model among leadership in selected township and township area markets of South Africa and the impact on the organisation’s overall performance. In today’s global-ized world, businesses look to expand and set foot print across various markets to have a global presence. Quick Service Restau-rants (QSR) businesses have expanded internationally and locally including townships markets using franchising business model to contribute to the social economy. The study used a qualitative descriptive exploratory method. The main finding of the study was that the QSR model in the township brought convenience, cost effectiveness, accessibility to value bulk buying of meals and Wi-Fi connection The communities and the restaurants found opportunities to contribute to social development and job creation. High levels of criminal activities, customer interference with employees, limited consumer bulk meal of choices, power, and water shortages where the key challenges affecting the viability of the QSR model
The Role of Inflation in Moderate Interaction of Gold Rolling Spots and Macroeconomic Variables on the ICDX Exchange
Authors: Dewi Syarif, MM Dr. Ir. Andam ,   Universitas Mercu Buana, SE, MSc.IBF Najim Nur Fauziah, ,   Indonesian Commodity and Derivative Exchange (ICDX)
Published: July 2024

Gold has played an essential role in building payment systems in the past and remains a popular investment product today. One such investment product is the Gold Rolling Spot, a variation of a futures contract derivative transaction traded on the Indonesian Commodity and Derivatives Exchange (ICDX). Nevertheless, no research has been done since this sort of investment is exclusive to ICDX. This study uses inflation as the moderation to analyze the effect of the Indonesia Composite Index (ICI) return, Interest Rate, and Exchange Rate (USD/IDR) return on the Gold Rolling Spot return. This study used monthly data for the period January 2020 until December 2023. The analysis technique used is Moderated Regression Analysis (MRA). The results concluded that ICI return has a significant positive effect on Gold Rolling Spot return, while interest rate, exchange rate (USD/IDR) return, and Inflation, have a significant negative impact on Gold Rolling Spot return. Inflation moderates the effect of interest rate and exchange rate (USD/IDR) return on Gold Rolling Spot return. However, Inflation does not moderate the impact of ICI return on Gold Rolling Spot return.
The Effect of Leadership Style and Compensation on Employee Performance Mediated by Job Satisfaction (Case Study at Pelita Maumere Hotel)
Authors: David Putri Theresia Anjelin Megawati ,   Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA), Surabaya, Indonesia, Suhermin Suhermin , Satrio Budi ,   Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA), Surabaya, Indonesia,   Sekolah Tinggi Ilmu Ekonomi Indonesia (STIESIA), Surabaya, Indonesia
Published: July 2024

This study aimed to find out and analyze the effect of leadership style and compensation on employees' performance through job satisfaction. The study was associative / correlational. Moreover, the data were both primary and secondary. The primary data were taken directly from respondents through questionnaires. Furthermore, secondary data were in the form of library research, journals, and document information taken from online systems (internet). The population was 40 employers at the Pelita Maumere Hotel. Additionally, the data collection technique uses non-probability sampling. The sampling technique used was saturated sampling or census. In addition, the data analysis technique used path analysis. The results showed that leadership style as well as compensation affected job satisfaction. However, both leadership style, compensation, and job satisfaction did not affect the performance. Likewise, leadership style and compensation did not affect employees' performance through job satisfaction.
The Effect of Job Satisfaction, Performance, Apparatus Competence, Through Village Financial Management on the Effectiveness of Village Development Programs in South Tanimbar District
Authors: Masela Yulita Maria ,   University of Merdeka Malang, Indonesia, Subiyantoro Edi , Sunardi Sunardi ,   University of Merdeka Malang, Indonesia,   University of Merdeka Malang, Indonesia
Published: July 2024

The aim of this research is; 1) to describe job satisfaction, performance, apparatus competency, village financial management, and the effectiveness of village development programs in South Tanimbar sub-district; 2) to analyze the influence of job satisfaction, performance, competence of officials, and village financial management on the effectiveness of village development programs on the effectiveness of village development programs in Tanimbar Selatan District; 3) to analyze the influence of job satisfaction, performance and competency of apparatus on the effectiveness of village development programs in Tanimbar Selatan sub-district; 4) to analyze the influence of village financial management on the effectiveness of village development programs in Tanimbar Selatan District; 5) to analyze job satisfaction, performance, and competency of officials on the effectiveness of village development programs through village financial management in Tanimbar Selatan subdistrict. This research uses a quantitative approach method. The population in this study was 10 villages with 100 village officials. The sampling technique uses path analysis so that the sample used is 100 people. The analysis techniques used are descriptive analysis and path analysis. The results of this research are; 1) The results of descriptive statistical analysis of the variables of job satisfaction, performance, apparatus competency, financial management, and effectiveness of development programs provide an illustration that the majority of village officials in South Tanimbar sub-district tend to be active in carrying out their duties and responsibilities at work. Village officials are considered good at their work. Financial management is one of the factors that can encourage employee enthusiasm in working to achieve good work results by relying on the size and level of effectiveness of development programs; 2) job satisfaction has a significant influence on village financial management in South Tanimbar sub-district; 3) performance has a significant influence on the effectiveness of village development in South Tanimbar District. 4) Apparatus competence has a significant influence on the effectiveness of village development in South Tanimbar District. 5) financial management has a significant influence on the effectiveness of village development programs in South Tanimbar sub-district. 6) job satisfaction, performance, apparatus competency. Job satisfaction is the most important part for agencies to pay attention to and consider, because through job satisfaction employee work results can be achieved.
Infectious Diseases
Authors: Benharroch Daniel ,   Department of Pathology, Soroka University Medical Center, and Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel
Published: July 2024

Infectious Diseases
MUMMERY IN THE MODERN MEDIA SPACE: TRANSFORMATION OF TRADITION AND IDEOLOGICAL CONFLICT
Authors: Saveleva Tatyana V.
Published: July 2024

Russian ceremonial mummery is an archaic tradition, the study of which in Russian folklore begins in the middle of the XIX century and continues to the present. This study examines the transformation of tradition and its existence at the present stage. We distinguish three forms of existence: sacred, professional-commercial and profane. The first one is considered on the example of Slavic communities that revitalize the sacred aspect of mummery, community pages on the VKontakte social network are analyzed. The second is represented by groups of professional buffoons reviving the skills of mummers, hookers, masks. The third form of existence is considered on the example of the “naked party”, which clearly shows the desacralization of tradition and the simulation of the sacred in festive culture.
FOUR STAGES OF THE EVOLUTION OF THINKING: EXPLICATION OF THE WORLD MIND
Authors: Strigin Mikhail B.
Published: July 2024

In this paper, it is assumed that human thinking has gone through four characteristic phase stages of evolution. At the first stage, thinking was correlated with the scale of the individual. At the second stage, the scale of thinking changed from corresponding to the size of the tribe to correlating with the whole of humanity. When thinking rested on the boundaries of its own kind, the next phase transition occurred, and wildlife was included in the composition of thinking. In turn, the boundaries of the living determined the final metamorphosis, which included in the thinking procedures inanimate nature.