bluuebunny/crossref_metadata_2025 huggingface dataset:
5mC-Related lncRNAs as Potential Prognostic Biomarkers in Colon Adenocarcinoma
Authors: Huang Yinghui , Huang Huiqian , Wang Yong , Liu Hui , Huang Yingdan
Published: February 2022

Globally, colon adenocarcinoma (COAD) is one of the most frequent types of malignant tumors. About 40~50% of patients with advanced colon adenocarcinoma die from recurrence and metastasis. Long non-coding RNAs (lncRNAs) and 5-methylcytosine (5mC) regulatory genes have been demonstrated to involve in the progression and prognosis of COAD. The goal of this study was to explore the biological characteristics and potential predictive value of 5mC-related lncRNA signature in COAD. In this research, The Cancer Genome Atlas (TCGA) was utilized to obtain the expression of genes and somatic mutations in COAD, and Pearson correlation analysis was used to select lncRNAs involved in 5mC-regulated genes. Furthermore, we applied univariate Cox regression and Lasso Cox regression to construct 5mC-related lncRNA signature. Then Kaplan–Meier survival analysis, principal components analysis (PCA), receiver operating characteristic (ROC) curve, and a nomogram were performed to estimate the prognostic effect of the risk signature. GSEA was utilized to predict downstream access of the risk signature. Finally, the immune characteristics and immunotherapeutic signatures targeting this risk signature were analyzed. In the results, we obtained 1652 5mC-related lncRNAs by Pearson correlation analysis in the TCGA database. Next, we selected a risk signature that comprised 4 5mC-related lncRNAs by univariate and Lasso Cox regression. The prognostic value of the risk signature was proven. Finally, the biological mechanism and potential immunotherapeutic response of the risk signature were identified. Collectively, we constructed the 5mC-related lncRNA risk signature, which could provide a novel prognostic prediction of COAD patients.
The Honey Bee Apis mellifera: An Insect at the Interface between Human and Ecosystem Health
Authors: Papa Giulia , Maier Roberto , Durazzo Alessandra , Lucarini Massimo , Karabagias Ioannis K. , Plutino Manuela , Bianchetto Elisa , Aromolo Rita , Pignatti Giuseppe , Ambrogio Andrea , Pellecchia Marco , Negri Ilaria
Published: February 2022

The concept of ecosystem services is widely understood as the services and benefits thatecosystems provide to humans, and they have been categorised into provisioning, regulating, supporting, and cultural services. This article aims to provide an updated overview of the benefits that the honey bee Apis mellifera provides to humans as well as ecosystems. We revised the role of honey bees as pollinators in natural ecosystems to preserve and restore the local biodiversity of wild plants; in agro-ecosystems, this species is widely used to enhance crop yield and quality, meeting the increasing food demand. Beekeeping activity provides humans not only with high-quality food but also with substances used as raw materials and in pharmaceuticals, and in polluted areas, bees convey valuable information on the environmental presence of pollutants and their impact on human and ecosystem health. Finally, the role of the honey bee in symbolic tradition, mysticism, and the cultural values of the bee habitats are also presented. Overall, we suggest that the symbolic value of the honey bee is the most important role played by this insect species, as it may help revitalise and strengthen the intimate and reciprocal relationship between humans and the natural world, avoiding the inaccuracy of considering the ecosystems as mere providers of services to humans.
Wood Waste from Fruit Trees: Biomolecules and Their Applications in Agri-Food Industry
Authors: Aliaño-González Maria Jose , Gabaston Julien , Ortiz-Somovilla Victor , Cantos-Villar Emma
Published: February 2022

In the European Union (EU), a total of 11,301,345 hectares are dedicated to the cultivation of fruit trees, mainly olive orchards, grapevines, nut trees (almond, walnut, chestnut, hazelnut, and pistachio), apple and pear trees, stone fruit trees (peach, nectarine, apricot, cherry, and plum), and citrus fruit trees (orange, clementine, satsuma, mandarin, lemon, grapefruit, and pomelo). Pruning these trees, together with plantation removal to a lesser extent, produces a huge amount of wood waste. A theoretical calculation of the wood waste in the European Union estimates approximately 2 and 25 million tons from wood plantation removal and pruning, respectively, per year. This wood waste is usually destroyed by in-field burning or crushing into the soil, which result in no direct economic benefits. However, wood from tree pruning, which is enriched in high added-value molecules, offers a wide spectrum of possibilities for its valorization. This review focuses on the contribution of wood waste to both sustainability and the circular economy, considering its use not only as biomass but also as a potential source of bioactive compounds. The main bioactive compounds found in wood are polyphenols, terpenes, polysaccharides, organic compounds, fatty acids, and alkaloids. Polyphenols are the most ubiquitous compounds in wood. Large amounts of hydroxytyrosol (up to 25 g/kg dw), resveratrol (up to 66 g/kg dw), protocatechuic acid (up to 16.4 g/kg), and proanthocyanins (8.5 g/kg dw) have been found in the wood from olive trees, grapevines, almond trees and plum trees, respectively. The bioactivity of these compounds has been demonstrated at lower concentrations, mainly in vitro studies. Bioactive compounds present antioxidant, antimicrobial, antifungal, biostimulant, anti-inflammatory, cardioprotective, and anticarcinogenic properties, among others. Therefore, wood extracts might have several applications in agriculture, medicine, and the food, pharmaceutical, nutraceutical, and cosmetics industries. For example, olive tree wood extract reduced thrombin-induced platelet aggregation in vitro; grapevine tree wood extract acts a preservative in wine, replacing SO2; chestnut tree wood extract has antifungal properties on postharvest pathogens in vitro; and stone tree wood extracts are used for aging both wines and brandies. Moreover, the use of wood waste contributes to the move towards both a more sustainable development and a circular economy.
AutoCellANLS: An Automated Analysis System for Mycobacteria-Infected Cells Based on Unstained Micrograph
Authors: Zhuang Yan , Zhao Xinzhuo , Huang Zhongbing , Han Lin , Chen Ke , Lin Jiangli
Published: February 2022

The detection of Mycobacterium tuberculosis (Mtb) infection plays an important role in the control of tuberculosis (TB), one of the leading infectious diseases in the world. Recent advances in artificial intelligence-aided cellular image processing and analytical techniques have shown great promises in automated Mtb detection. However, current cell imaging protocols often involve costly and time-consuming fluorescence staining, which has become a major bottleneck for procedural automation. To solve this problem, we have developed a novel automated system (AutoCellANLS) for cell detection and the recognition of morphological features in the phase-contrast micrographs by using unsupervised machine learning (UML) approaches and deep convolutional neural networks (CNNs). The detection algorithm can adaptively and automatically detect single cells in the cell population by the improved level set segmentation model with the circular Hough transform (CHT). Besides, we have designed a Cell-net by using the transfer learning strategies (TLS) to classify the virulence-specific cellular morphological changes that would otherwise be indistinguishable to the naked eye. The novel system can simultaneously classify and segment microscopic images of the cell populations and achieve an average accuracy of 95.13% for cell detection, 95.94% for morphological classification, 94.87% for sensitivity, and 96.61% for specificity. AutoCellANLS is able to detect significant morphological differences between the infected and uninfected mammalian cells throughout the infection period (2 hpi/12 hpi/24 hpi). Besides, it has overcome the drawback of manual intervention and increased the accuracy by more than 11% compared to our previous work, which used AI-aided imaging analysis to detect mycobacterial infection in macrophages. AutoCellANLS is also efficient and versatile when tailored to different cell lines datasets (RAW264.7 and THP-1 cell). This proof-of concept study provides a novel venue to investigate bacterial pathogenesis at a macroscopic level and offers great promise in the diagnosis of bacterial infections.
Regulatory Cells in Multiple Sclerosis: From Blood to Brain
Authors: Calahorra Leticia , Camacho-Toledano Celia , Serrano-Regal Mari Paz , Ortega María Cristina , Clemente Diego
Published: February 2022

Multiple sclerosis (MS) is a chronic, autoimmune, and neurodegenerative disease of the central nervous system (CNS) that affects myelin. The etiology of MS is unclear, although a variety of environmental and genetic factors are thought to increase the risk of developing the disease. Historically, T cells were considered to be the orchestrators of MS pathogenesis, but evidence has since accumulated implicating B lymphocytes and innate immune cells in the inflammation, demyelination, and axonal damage associated with MS disease progression. However, more recently the importance of the protective role of immunoregulatory cells in MS has become increasingly evident, such as that of myeloid-derived suppressor cells (MDSCs), regulatory T (Treg) and B (Breg) cells, or CD56bright natural killer cells. In this review, we will focus on how peripheral regulatory cells implicated in innate and adaptive immune responses are involved in the physiopathology of MS. Moreover, we will discuss how these cells are thought to act and contribute to MS histopathology, also addressing their promising role as promoters of successful remyelination within the CNS. Finally, we will analyze how understanding these protective mechanisms may be crucial in the search for potential therapies for MS.
Dissociation of Bone Resorption and Formation in Spaceflight and Simulated Microgravity: Potential Role of Myokines and Osteokines?
Authors: Lau Patrick , Vico Laurence , Rittweger Jörn
Published: February 2022

The dissociation of bone formation and resorption is an important physiological process during spaceflight. It also occurs during local skeletal unloading or immobilization, such as in people with neuromuscular disorders or those who are on bed rest. Under these conditions, the physiological systems of the human body are perturbed down to the cellular level. Through the absence of mechanical stimuli, the musculoskeletal system and, predominantly, the postural skeletal muscles are largely affected. Despite in-flight exercise countermeasures, muscle wasting and bone loss occur, which are associated with spaceflight duration. Nevertheless, countermeasures can be effective, especially by preventing muscle wasting to rescue both postural and dynamic as well as muscle performance. Thus far, it is largely unknown how changes in bone microarchitecture evolve over the long term in the absence of a gravity vector and whether bone loss incurred in space or following the return to the Earth fully recovers or partly persists. In this review, we highlight the different mechanisms and factors that regulate the humoral crosstalk between the muscle and the bone. Further we focus on the interplay between currently known myokines and osteokines and their mutual regulation.
Human Milk Oligosaccharides: Potential Applications in COVID-19
Authors: Chutipongtanate Somchai , Morrow Ardythe L. , Newburg David S.
Published: February 2022

Coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) has become a global health crisis with more than four million deaths worldwide. A substantial number of COVID-19 survivors continue suffering from long-COVID syndrome, a long-term complication exhibiting chronic inflammation and gut dysbiosis. Much effort is being expended to improve therapeutic outcomes. Human milk oligosaccharides (hMOS) are non-digestible carbohydrates known to exert health benefits in breastfed infants by preventing infection, maintaining immune homeostasis and nurturing healthy gut microbiota. These beneficial effects suggest the hypothesis that hMOS might have applications in COVID-19 as receptor decoys, immunomodulators, mucosal signaling agents, and prebiotics. This review summarizes hMOS biogenesis and classification, describes the possible mechanisms of action of hMOS upon different phases of SARS-CoV-2 infection, and discusses the challenges and opportunities of hMOS research for clinical applications in COVID-19.
The Alternative RelB NF-kB Subunit Exerts a Critical Survival Function upon Metabolic Stress in Diffuse Large B-Cell Lymphoma-Derived Cells
Authors: Nuan-Aliman Stéphanie , Bordereaux Didier , Thieblemont Catherine , Baud Véronique
Published: February 2022

Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma in adults and reveals distinct genetic and metabolic signatures. NF-κB transcription factor family is involved in diverse biological processes enabling tumor development and resistance to anticancer-therapy through activation of its two main pathways, the canonical and the alternative NF-κB pathways, the main actor of the latter being the RelB NF-kB subunit. RelB DNA binding activity is frequently activated in DLBCL patients and cell lines. RelB activation defines a new DLBCL subgroup with dismal outcome upon immunochemotherapy, and RelB confers DLBCL cell resistance to DNA damage. However, whether RelB can impact on DLBCL cell metabolism and survival upon metabolic stress is unknown. Here, we reveal that RelB controls DLBCL oxidative energetic metabolism. Accordingly, RelB inhibition reduce DLBCL mitochondrial ATP production, and sensitizes DLBCL cells to apoptosis induced by Metformin and L-asparaginase (®Kidrolase), two FDA approved antimetabolic drugs targeting mitochondrial metabolism. RelB also confers DLBCL cell resistance to glutamine deprivation, an essential amino acid that feeds the TCA cycle. Taken together, our findings uncover a new role for RelB in the regulation of DLBCL cell metabolism and DLBCL cell survival upon metabolic stress.
Misuse of Anticholinergic Medications: A Systematic Review
Authors: Chiappini Stefania , Mosca Alessio , Miuli Andrea , Semeraro Francesco Maria , Mancusi Gianluca , Santovito Maria Chiara , Di Carlo Francesco , Pettorruso Mauro , Guirguis Amira , Corkery John Martin , Martinotti Giovanni , Schifano Fabrizio , Di Giannantonio Massimo
Published: February 2022

(1) Background: Over the last decade, misuse and diversion of medications has appeared to be increasingly concerning phenomena, including a range of different molecules. As current knowledge on the abuse of centrally acting anticholinergics is limited, the aim of the present study is to review the relevant published data, focusing on the following molecules: benztropine, biperiden, scopolamine, orphenadrine, and benzhexol/trihexyphenidyl (THP). (2) Methods: A systematic literature review was carried out using Pubmed, Scopus, and Web of Science databases following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). Research methods were registered on PROSPERO (CRD42021257293). (3) Results: A total of 48 articles, including case reports, surveys, and retrospective case series analyses, were included. Most articles focused on benzhexol/THP (n = 25), and benztropine (n = 4). The routes of administration were mostly oral, and macrodoses together concomitant illicit drugs, e.g., cocaine, have been recorded. Toxidromes included both physical (e.g., tachycardia, tachypnoea, dilatated pupils, dry skin, urinary retention, ataxia, etc.) and psychiatric symptoms (e.g., anxiety, agitation, delirium, etc.). Fatal outcomes were very rare but reported. (4) Conclusion: Results from the present study show that anticholinergic misusing issues are both widespread worldwide and popular. Considering the potential adverse effects associated, healthcare professionals should be vigilant and monitor eventual misusing issues.
Investigation of Indoor Polycyclic Aromatic Hydrocarbons (PAHs) in Rural Northeast China: Pollution Characteristics, Source Analysis, and Health Assessment
Authors: Bai Li , Li Chunhui
Published: February 2022

Due to the low winter temperatures in rural areas of Northeast China, biomass fuels are widely used for heating and cooking, resulting in increased concentrations of PAHs in rural indoor areas during the heating period and threatening human health. Therefore, exploring the pollution characteristics, source localization, and risk assessment of indoor PAHs in rural Northeast China is of great significance for improving rural indoor air quality. In this study, PAHs were collected from a residential building in rural Northeast China for one consecutive year (January 2020–December 2020), and their concentrations were determined to explore the distribution patterns and sources of PAHs to further assess the carcinogenic risk of PAHs to humans. The results of the study showed that the average concentration of indoor PAHs in rural areas during the heating period (93.02 ng/m3) was about 1.81 times higher than that of the non-heating period (51.26 ng/m3). The main sources of PAHs were mixed combustion of biomass and coal, motor vehicle emissions, and domestic waste combustion. The level of indoor PAHs pollution has posed a carcinogenic risk to the health of the rural population in the Northeast.
3D Printing Filaments Facilitate the Development of Evanescent Wave Plastic Optical Fiber (POF) Chemosensors
Authors: Darder Maria del Mar , Serrano Luis A. , Bedoya Maximino , Orellana Guillermo
Published: February 2022

One of the major difficulties in the development of evanescent wave optical fiber sensors (EWOFS) lies in the complexity of the manufacturing of the chemosensitive element, particularly when using plastic optical fibers (POFs). While these fibers are appealing waveguides thanks to their low cost, ease of connectorization and robustness, the need for removing the cladding material complicates the EWOFS fabrication. In this paper we discuss how 3D printing filaments can serve as an alternative to commercially available POF for the development of EWOFS. In the process of replacing the traditional POF, we compared the performance of two EWOFS for monitoring airborne formaldehyde. These sensitive elements were manufactured either from 1.75 mm diameter 3D printing filaments, or from a commercially available POF. After the optimization of their respective fabrication protocols, the analytical performance of the two formaldehyde EWOFS was compared in terms of sensitivity and reproducibility. In this regard, the easy-to-manufacture 3D printing filament-based waveguides provided 5-fold lower detection limits with respect to the commercial POF-based sensors. Although no statistically significant differences were found in terms of reproducibility, the simplification of the sensor manufacturing process together with the increased analytical performance for chemical sensing spur the use of 3D printing filaments for the development of new POF-based EWOFS.
Preparation and Properties of Directionally Solidified Ni-Al Based Alloys Modified by Molybdenum
Authors: Malcharcziková Jitka , Skotnicová Kateřina , Kawulok Petr , Kawulok Rostislav , Szurman Ivo , Růžička Jana
Published: February 2022

Ni-Al-Mo based alloys can be used as materials for high temperature applications. They can be prepared by various techniques such as an electron beam zone melting, which allows us to obtain the alloys with a directionally solidified structure and unique properties. A plasma-melted Ni-Mo master alloy was used for the preparation of the experimental alloys. Ni-Al-Mo alloys were melted in an induction furnace and then cast centrifugally in the form of bars. These bars were then re-melted in the electron beam zone furnace. The structure of these alloys was multi-phase. The structure was formed by the phases Ni3(Al,Mo) and (Ni) with variable content of molybdenum. The structure also contained particles rich in molybdenum (Mo, MoNi). The alloys were submitted to the compression tests at a temperature of 800 °C. The yield strength of alloys achieved the value of approx. 800 MPa. The different molybdenum content affected the values of the maximal flow stress. The alloys with higher molybdenum content showed higher maximal flow stress, namely approx. 1300 MPa. The results show that these alloys are very promising for the production of structural components operating at elevated temperatures.
Studying Abroad from Home: An Exploration of International Graduate Students’ Perceptions and Experiences of Emergency Remote Teaching
Authors: Dong Yanning , Ishige Aika
Published: February 2022

The temporary shift from face-to-face instruction to online teaching at North American universities as an alternative solution in response to the COVID-19 pandemic brought significant challenges to international students who had to study abroad from their home countries. Studies on how international students perceive their study-abroad-from-home experiences in such an emergency remote teaching (ERT) context remain scarce. Through the lens of community of inquiry and an additional perspective of emotional presence, this study explored 13 first-year international graduate students’ perceptions and experiences of their learning in ERT. Based on the analyses of the pre-learning questionnaire survey results and a series of three reflection journal entries, the study finds that teaching presence has played a vital role in shaping students’ understanding and experiences when they participated in a study-abroad graduate program from their home countries. In addition, the participants demonstrated mixed emotions of both frustration and appreciation/thankfulness as well as an isolation–connectedness emotional trajectory during their learning process. The study inspires an exploration of more diverse options for international education programs and continued effort in providing institutional support to ensure better learning experiences in a post-COVID community of inquiry.
Exploring Educator Leadership Practices in Gifted Education to Facilitate Online Learning Experiences for (Re)Engaging Gifted Students
Authors: Ronksley-Pavia Michelle , Neumann Michelle M.
Published: February 2022

This article draws on case study findings of educator leadership in an online gifted education school, which emerged from a larger study exploring online engagement practices used by specialist gifted education teachers to (re)engage gifted learners. The gifted education teachers and their team leader were interviewed about leadership practices for supporting online engagement of gifted primary and high school students. Semi-structured interview data were transcribed, coded, and thematically analysed. Findings related to teachers voicing the importance of a passionate and committed team leader who understood giftedness and who acted as a facilitator in both the continuous development of teaching team skills and facilitation of online engagement practices for gifted students. Findings indicated five key themes related to transformational leadership practices: (1) understanding requirements of online practices for teaching gifted students; (2) supporting digital and online innovation and creativity for engaging gifted students; (3) leveraging the unique skills of the specialist teaching team for teaching gifted students in the online space; (4) actively facilitating and encouraging (re)engagement of gifted students through online participation; (5) follow-through to meet the needs and concerns of the specialist teaching team, gifted students, and their parents and/or carers. These leadership practices are of importance for actively supporting gifted education teachers and their students in online learning environments in order to achieve positive student engagement and learning outcomes commensurate with student potential.
Initial Design and Testing of Multiplayer Cooperative Game to Support Physical Activity in Schools
Authors: Oyelere Solomon Sunday , Berghem Simon Malmström , Brännström Robert , Rutberg Stina , Laine Teemu H. , Lindqvist Anna-Karin
Published: February 2022

Recent studies have shown that children are not adequately physically active and there is a need to increase children’s physical activity. This study describes new opportunities and solutions for using existing games and gamification to increase physical activity among children in Sweden. We adopted the principles of Tic-Tac-Training to redesign, build, and test a classical multiplayer cooperative game, Battleship, to create a PA game that children experience as fun and engaging. The low fidelity prototype of the game was developed using an iterative game development life cycle and tested with 13 young male children aged 8–11 in a real-world informal setting. A mixed-method research approach was used to understand the users’ experiences and the impact of the Battleship-PA game on behavior change regarding physical activity. Research data were collected through audio recordings of interactions, direct observation, and a user experience questionnaire. The results of this study indicate both positive and negative feedback that can be used to improve the game and user experiences. The results from the unfiltered recordings revealed that both teams were competitive, cooperated within their team, and became excited whenever they destroyed opponent’s ships or were close to winning. However, the children felt bored and exhausted when many gamification tasks were repeated several times in a game session. Direct observation indicated that the children enjoyed the physical activities resulting from playing the game. However, participants who had not previously played the classical version of Battleship were confused about the objectives and concept of the game. The analysis of the user experience questionnaire indicated that most children found the game easy to play, motivating, engaging, interactive, fun, cooperative, competitive, and visually appealing. Furthermore, most children agreed that the game helped them to be physically active and strongly agreed that they enjoyed performing the physical activities in the game. Future work is needed to improve the game user interface, gamification elements, and prepare additional physical activity tasks for a rewarding experience.
A Comprehensive Review on the Use of Metal–Organic Frameworks (MOFs) Coupled with Enzymes as Biosensors
Authors: Souza José E. da S. , Oliveira Gabriel P. de , Alexandre Jeferson Y. N. H. , Neto José G. L. , Sales Misael B. , Junior Paulo G. de S. , Oliveira André L. B. de , Souza Maria C. M. de , Santos José C. S. dos
Published: February 2022

Several studies have shown the development of electrochemical biosensors based on enzymes immobilized in metal–organic frameworks (MOFs). Although enzymes have unique properties, such as efficiency, selectivity, and environmental sustainability, when immobilized, these properties are improved, presenting significant potential for several biotechnological applications. Using MOFs as matrices for enzyme immobilization has been considered a promising strategy due to their many advantages compared to other supporting materials, such as larger surface areas, higher porosity rates, and better stability. Biosensors are analytical tools that use a bioactive element and a transducer for the detection/quantification of biochemical substances in the most varied applications and areas, in particular, food, agriculture, pharmaceutical, and medical. This review will present novel insights on the construction of biosensors with materials based on MOFs. Herein, we have been highlighted the use of MOF for biosensing for biomedical, food safety, and environmental monitoring areas. Additionally, different methods by which immobilizations are performed in MOFs and their main advantages and disadvantages are presented.
Acceptance of Cultured Meat in Germany—Application of an Extended Theory of Planned Behaviour
Authors: Dupont Jacqueline , Harms Tess , Fiebelkorn Florian
Published: February 2022

This study examines the willingness to consume a cultured meat burger in Germany. Based on the theory of planned behaviour (TPB), we assessed attitudes, perceived behavioural control, and subjective norms via an online questionnaire. Attitudes were operationalized in this research as general attitudes towards cultured meat and specific attitudes towards a cultured meat burger. Furthermore, the TPB was extended with nutritional-psychological variables including food (technology) neophobia, food disgust, sensation seeking, and green consumption values. In total, 58.4% of the participants reported being willing to consume a cultured meat burger. Using a path model, the extended TPB accounted for 77.8% of the variance in willingness to consume a cultured meat burger. All components of the TPB were significant predictors except general attitudes. The influence of general attitudes was completely mediated by specific attitudes. All nutritional-psychological variables influenced general attitudes. Food technology neophobia was the strongest negative, and green consumption values were the strongest positive predictor of general attitudes. Marketing strategies should therefore target the attitudes of consumers by encouraging the natural perception of cultured meat, using a less technological product name, enabling transparency about the production, and creating a dialogue about both the fears and the environmental benefits of the new technology.
Lessons from the Ionised and Molecular Mass of Post-CE PNe
Authors: Santander-García Miguel , Jones David , Alcolea Javier , Bujarrabal Valentín , Wesson Roger
Published: February 2022

Close binary evolution is widely invoked to explain the formation of axisymmetric planetary nebulae after a brief common envelope phase. The evolution of the primary would be interrupted abruptly, its still quite massive envelope being fully ejected to form the PN, which should be more massive than a planetary nebula coming from the same star, were it single. We test this hypothesis by investigating the ionised and molecular masses of a sample consisting of 21 post-common-envelope planetary nebulae, roughly one-fifth of their known total population, and comparing them to a large sample of regular planetary nebulae (not known to host close-binaries). We find that post-common-envelope planetary nebulae arising from single-degenerate systems are, on average, neither more nor less massive than regular planetary nebulae, whereas post-common-envelope planetary nebulae arising from double-degenerate systems are considerably more massive and show substantially larger linear momenta and kinetic energy than the rest. The reconstruction of the common envelope of four objects further suggests that the mass of single-degenerate nebulae actually amounts to a very small fraction of the envelope of their progenitor stars. This leads to the uncomfortable question of where the rest of the envelope is, raising serious doubts on our understanding of these intriguing objects.
Health Management in Italian Prisons during COVID-19 Outbreak: A Focus on the Second and Third Wave
Authors: Vella Raimondo , Giuga Gabriele , Piizzi Giorgia , Alunni Fegatelli Danilo , Petroni Giulia , Tavone Alessandro Mauro , Potenza Saverio , Cammarano Andrea , Mandarelli Gabriele , Marella Gian Luca
Published: February 2022

The SARS-CoV-2 spread is a threatening and challenging issue for correctional systems worldwide because of many factors, particularly overcrowding and of the intrinsic characteristics of the population. The prevention measures adopted by the Italian Government were aimed to protect and preserve both inmates’ and prison workers’ health. The present study aimed to evaluate the efficacy of the adopted strategies. Methods: Data regarding Italian prisons’ occupation and prisoners’ population from January 2019 to June 2021, as well as the cumulative weekly increase of confirmed cases and the number of doses of vaccine administered among the population of inmates, the prison workers, and Italian population from November 2020 to the end of June 2021, were collected. Results: Prisons’ occupation dropped from 120% to 106% after the beginning of the pandemics. The confirmed cases between inmates were consistently lower than among the Italian population and prison workers. A time-series chart showed a time lag of one week between the peaks of the different population. Conclusions: The containing strategies adopted by the Italian correctional system have proved their effectiveness in terms of the prevention and protection of both inmate and staff health.
Diagnostic Policies Optimization for Chronic Diseases Based on POMDP Model
Authors: Zhang Wenqian , Wang Haiyan
Published: February 2022

During the process of disease diagnosis, overdiagnosis can lead to potential health loss and unnecessary anxiety for patients as well as increased medical costs, while underdiagnosis can result in patients not being treated on time. To deal with these problems, we construct a partially observable Markov decision process (POMDP) model of chronic diseases to study optimal diagnostic policies, which takes into account individual characteristics of patients. The objective of our model is to maximize a patient’s total expected quality-adjusted life years (QALYs). We also derive some structural properties, including the existence of the diagnostic threshold and the optimal diagnosis age for chronic diseases. The resulting optimization is applied to the management of coronary heart disease (CHD). Based on clinical data, we validate our model, demonstrate how the quantitative tool can provide actionable insights for physicians and decision makers in health-related fields, and compare optimal policies with actual clinical decisions. The results indicate that the diagnostic threshold first decreases and then increases as the patient’s age increases, which contradicts the intuitive non-decreasing thresholds. Moreover, diagnostic thresholds were higher for women than for men, especially at younger ages.
Subcutaneous Emphysema Related to Dental Treatment: A Case Series
Authors: Shimizu Rieko , Sukegawa Shintaro , Sukegawa Yuka , Hasegawa Kazuaki , Ono Sawako , Fujimura Ai , Yamamoto Izumi , Ibaragi Soichiro , Sasaki Akira , Furuki Yoshihiko
Published: February 2022

Cervicofacial subcutaneous emphysema (SE) is primarily caused by dental treatment introducing gas into the subcutaneous tissue. Air rapidly dissects into the subcutaneous tissue with face and neck swelling, leading to respiratory distress, patient discomfort, and chest pain. Computed tomography (CT) can detect spreading SE patterns. However, the true volume of SE and the degree of air changes in the body over time remain unknown. We evaluated the healing process of SE and the temporal changes in the volume of emphysema in three cases detected using our hospital’s electronic health record systems based on inclusion and exclusion criteria over the past 10 years, with CT and three-dimensional (3D) images. The first case was a 46-year-old woman who presented with complaints of swelling from her right eyelid to the neck and clavicles, pain on swallowing, respiratory distress, and hoarseness. The second case was a 35-year-old man who presented with complaints of swelling over the face. The third case was a 36-year-old man who presented with complaints of swelling from the left cheek to the neck. CT revealed SE and pneumomediastinum in all cases. All the patients were administered an antibacterial drug. The CT and 3D images showed an improvement in emphysema 3 days after the onset, with more than half of the volume reduction in emphysema. This made it possible to evaluate the changes in the air content of SE. Observation with CT until the healing process of SE is completed is crucial, and 3D images also help evaluate changes over time.
Conceptual Modelling of Two Large-Scale Mine Water Geothermal Energy Schemes: Felling, Gateshead, UK
Authors: Banks David , Steven Jonathan , Black Adam , Naismith John
Published: February 2022

A conceptual model is presented of two MW-scale low enthalpy mine water geothermal heat pump schemes that are being developed in Tyneside, UK. The Abbotsford Road scheme (54.955° N 1.556° W) is operating (as of May 2021) at 20–30 L/s, abstracting groundwater (and heat) from an unmined Coal Measures Upper Aquifer System (UAS) and reinjecting to the deeper High Main Aquifer System (HMAS), associated with the High Main (E) coal workings and the overlying High Main Post sandstone. A similar scheme, 700 m away at Nest Road (54.959° N 1.564° W), abstracts at 40 L/s from the HMAS, recovers heat from the mine water and reinjects the thermally spent water to deeper workings associated with the Hutton (L), Harvey-Beaumont (N) (and possibly other) coal seams, termed the Deep Mined Aquifer System (DMAS). The three aquifer systems are vertically discontinuous and possess different hydraulic (storage, transmissivity and continuity) properties that would have been near-impossible to predict in advance of drilling. At the sites, 10 boreholes were drilled to obtain five usable production/reinjection boreholes. Development of mine water geothermal energy schemes thus carries a significant project risk, and also a potential ongoing maintenance burden related to iron hydroxide scaling. These do not preclude mine water geothermal as a useful low carbon heating and cooling technology, but the involvement of skilled hydrogeologists, hydrochemists, mining and groundwater engineers is a pre-requisite.
Evaluating the Performance of Low-Cost Air Quality Monitors in Dallas, Texas
Authors: Khreis Haneen , Johnson Jeremy , Jack Katherine , Dadashova Bahar , Park Eun Sug
Published: February 2022

The emergence of low-cost air quality sensors may improve our ability to capture variations in urban air pollution and provide actionable information for public health. Despite the increasing popularity of low-cost sensors, there remain some gaps in the understanding of their performance under real-world conditions, as well as compared to regulatory monitors with high accuracy, but also high cost and maintenance requirements. In this paper, we report on the performance and the linear calibration of readings from 12 commercial low-cost sensors co-located at a regulatory air quality monitoring site in Dallas, Texas, for 18 continuous measurement months. Commercial AQY1 sensors were used, and their reported readings of O3, NO2, PM2.5, and PM10 were assessed against a regulatory monitor. We assessed how well the raw and calibrated AQY1 readings matched the regulatory monitor and whether meteorology impacted performance. We found that each sensor’s response was different. Overall, the sensors performed best for O3 (R2 = 0.36–0.97) and worst for NO2 (0.00–0.58), showing a potential impact of meteorological factors, with an effect of temperature on O3 and relative humidity on PM. Calibration seemed to improve the accuracy, but not in all cases or for all performance metrics (e.g., precision versus bias), and it was limited to a linear calibration in this study. Our data showed that it is critical for users to regularly calibrate low-cost sensors and monitor data once they are installed, as sensors may not be operating properly, which may result in the loss of large amounts of data. We also recommend that co-location should be as exact as possible, minimizing the distance between sensors and regulatory monitors, and that the sampling orientation is similar. There were important deviations between the AQY1 and regulatory monitors’ readings, which in small part depended on meteorology, hindering the ability of the low-costs sensors to present air quality accurately. However, categorizing air pollution levels, using for example the Air Quality Index framework, rather than reporting absolute readings, may be a more suitable approach. In addition, more sophisticated calibration methods, including accounting for individual sensor performance, may further improve performance. This work adds to the literature by assessing the performance of low-cost sensors over one of the longest durations reported to date.
Downscaling of AMSR-E Soil Moisture over North China Using Random Forest Regression
Authors: Zhang Hongyan , Wang Shudong , Liu Kai , Li Xueke , Li Zhengqiang , Zhang Xiaoyuan , Liu Bingxuan
Published: February 2022

Satellite retrieval can offer global soil moisture information, such as Advanced Microwave Scanning Radiometer-Earth Observing System (AMSR-E) data. AMSR-E has been used to provide soil moisture all over the world, with a coarse resolution of 25 km × 25 km. The coarse resolution of the soil moisture dataset often hinders its use in local or regional research. This work proposes a new framework based on the random forest (RF) model while using five auxiliary data to downscale the AMSR-E soil moisture data over North China. The downscaled results with a 1 km spatial resolution are verified against in situ measurements. Compared with AMSR-E data, the correlation coefficient of the downscaled data is increased by 0.17, and the root mean squared error, mean absolute error, and unbiased root mean square error are reduced by 0.02, 0.01, and 0.03 m3/m3, respectively. In addition, the comparison results with Multiple Linear Regression and Support Vector Regression downscaled data show that the proposed method significantly outperforms the other two methods. The feasibility of our model is well supported by the importance analysis and leave-one-out analysis. Our study, which combines RF with spatiotemporal search algorithms and efficient auxiliary data, may provide insights into soil moisture downscaling in large areas with various surface characteristics and climatic conditions.
Kidney Perfusion in Contrast-Enhanced Ultrasound (CEUS) Correlates with Renal Function in Living Kidney Donors
Authors: El-Bandar Nasrin , Lerchbaumer Markus H. , Peters Robert , Maxeiner Andreas , Kotsch Katja , Sattler Arne , Miller Kurt , Schlomm Thorsten , Hamm Bernd , Budde Klemens , Liefeldt Lutz , Fischer Thomas , Friedersdorff Frank
Published: February 2022

Contrast-enhanced ultrasound (CEUS) is a widely used diagnostic tool for analyzing perfusion and characterizing lesions in several organs. However, to date, it has not been sufficiently investigated whether there is an association between CEUS findings and kidney function. This study aimed at identifying the potential relationship between kidney function and the renal perfusion status determined by CEUS in living kidney donors. A total of 30 living kidney donors examined between April 2018 and March 2020 were included in the study. All patients underwent various diagnostic procedures for evaluation of renal function. CEUS was performed in all 30 donors one day before nephrectomy. Kidney perfusion was quantified using a postprocessing tool (VueBox, Bracco Imaging). Various perfusion parameters were subsequently analyzed and compared with the results of the other methods used to evaluate kidney function. Of all parameters, mean signal intensity (MeanLin) had the strongest correlation, showing significant correlations with eGFR (CG) (r = −0.345; p = 0.007) and total kidney volume (r = −0.409; p = 0.001). While there was no significant correlation between any perfusion parameter and diethylenetriaminepentaacetic acid (DTPA), we detected a significant correlation between MeanLin and DTPA (r = −0.502; p = 0.005) in the subgroup of normal-weight donors. The results indicate that signal intensity in CEUS is associated with kidney function in normal-weight individuals. Body mass index (BMI) may be a potential confounder of signal intensity in CEUS. Thus, more research is needed to confirm these results in larger study populations.
The Collateral Damage of the Pandemic on Non-COVID Related Pneumothorax Patients: A Retrospective Cohort Study
Authors: Woo Wongi , Kim Bong Jun , Kim Ji Hoon , Lee Sungsoo , Moon Duk Hwan
Published: February 2022

Background: Since the onset of the COVID-19 pandemic, there have been many reported cases showing the consequences—or the collateral damages—of COVID-19 on patients with non-COVID-related diseases. This study aimed to compare the clinical manifestations and treatment results of non-COVID-related pneumothorax patients before and during the pandemic. Methods: We retrospectively reviewed non-COVID-related pneumothorax patients who visited our hospital before the onset of the pandemic and during the pandemic. The primary outcome was the difference in the amount of pneumothorax between the two periods, and the secondary outcome was the difference in the treatment results between them. Multivariable logistic regression was conducted to find risk factors related to massive pneumothorax. Results: There were 122 and 88 patients in the pre-pandemic and pandemic groups, respectively. There was no significant difference between the two groups with respect to the preoperative demographic variables. However, the median amount of pneumothorax was significantly higher in the pandemic group (pre-pandemic: 34.75% [interquartile range (IQR) 18.30–62.95] vs. pandemic: 53.55% [IQR 33.58–88.80], p < 0.0001) and massive pneumothorax were more frequent in the pandemic group (52.3% vs. 30.3%, p = 0.002). Furthermore, more patients experienced re-expansion pulmonary edema after treatments during the pandemic (p = 0.0366). In multivariable analysis, the pandemic (OR: 2.70 [95% CI 1.49–4.90], p = 0.0011) was related to the occurrence of massive pneumothorax. Conclusion: During the pandemic, patients presented with a larger size of pneumothorax and had more re-expansion pulmonary edema, even in a country that handled the COVID-19 pandemic relatively well.
Evolution of Phytoplankton in Relation to Their Physiological Traits
Authors: Raven John A. , Beardall John
Published: February 2022

Defining the physiological traits that characterise phytoplankton involves comparison with related organisms in benthic habitats. Comparison of survival time in darkness under natural conditions requires more information. Gas vesicles and flagella as mechanisms of upward movement relative to surrounding water, allowing periodic vertical migration, are not confined to plankton, although buoyancy changes related to compositional changes of a large central vacuole may be restricted to plankton. Benthic microalgae have the same range of photosynthetic pigments as do phytoplankton; it is not clear if there are differences in the rate of regulation and acclimation of photosynthetic machinery to variations in irradiance for phytoplankton and for microphytobenthos. There are inadequate data to determine if responses to variations in frequency or magnitude of changes in the supply of inorganic carbon, nitrogen or phosphorus differ between phytoplankton and benthic microalgae. Phagophotomixotrophy and osmophotomixotrophy, occur in both phytoplankton and benthic microalgae. Further progress in identifying physiological traits specific to phytoplankton requires more experimentation on benthic microalgae that are closely related to planktonic microalgae, with attention to whether the benthic algae examined have, as far as can be determined, never been planktonic during their evolution or are derived from planktonic ancestors.