bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas6 ameliorates intestinal mucosal immunosenescence to prevent the translocation of a gut pathobiont, Klebsiella pneumoniae, to the liver
Authors: Tsugawa Hitoshi , Ohki Takuto , Tsubaki Shogo , Tanaka Rika , Matsuzaki Juntaro , Suzuki Hidekazu , Hozumi Katsuto
Published: June 2023

Immunosenescence refers to the development of weakened and/or dysfunctional immune responses associated with aging. Several commensal bacteria can be pathogenic in immunosuppressed individuals. Although Klebsiella pneumoniae is a commensal bacterium that colonizes human mucosal surfaces, the gastrointestinal tract, and the oropharynx, it can cause serious infectious diseases, such as pneumonia, urinary tract infections, and liver abscesses, primarily in elderly patients. However, the reason why K. pneumoniae is a more prevalent cause of infection in the elderly population remains unclear. This study aimed to determine how the host’s intestinal immune response to K. pneumoniae varies with age. To this end, the study analyzed an in vivo K. pneumoniae infection model using aged mice, as well as an in vitro K. pneumoniae infection model using a Transwell insert co-culture system comprising epithelial cells and macrophages. In this study, we demonstrate that growth arrest-specific 6 (Gas6), released by intestinal macrophages that recognize K. pneumoniae, inhibits bacterial translocation from the gastrointestinal tract by enhancing tight-junction barriers in the intestinal epithelium. However, in aging mice, Gas6 was hardly secreted under K. pneumoniae infection due to decreasing intestinal mucosal macrophages; therefore, K. pneumoniae can easily invade the intestinal epithelium and subsequently translocate to the liver. Moreover, the administration of Gas6 recombinant protein to elderly mice prevented the translocation of K. pneumoniae from the gastrointestinal tract and significantly prolonged their survival. From these findings, we conclude that the age-related decrease in Gas6 secretion in the intestinal mucosa is the reason why K. pneumoniae can be pathogenic in the elderly, thereby indicating that Gas6 could be effective in protecting the elderly against infectious diseases caused by gut pathogens.
Human cytomegalovirus UL138 interaction with USP1 activates STAT1 in infection
Authors: Zarrella Kristen , Longmire Pierce , Zeltzer Sebastian , Collins-McMillen Donna , Hancock Meaghan , Buehler Jason , Reitsma Justin M. , Terhune Scott S. , Nelson Jay A. , Goodrum Felicia
Published: June 2023

Innate immune responses are crucial for limiting virus infection. However, viruses often hijack our best defenses for viral objectives. Human Cytomegalovirus (HCMV) is a beta herpesvirus which establishes a life-long latent infection. Defining the virus-host interactions controlling latency and reactivation is vital to the control of viral disease risk posed by virus reactivation. We defined an interaction between UL138, a pro-latency HCMV gene, and the host deubiquitinating complex, UAF1-USP1. UAF1 is a scaffold protein pivotal for the activity of ubiquitin specific peptidases (USP), including USP1. UAF1-USP1 sustains an innate immune response through the phosphorylation and activation of signal transducer and activator of transcription-1 (pSTAT1), as well as regulates the DNA damage response. After the onset of viral DNA synthesis, pSTAT1 levels are elevated in infection and this depends upon UL138 and USP1. pSTAT1 localizes to viral centers of replication, binds to the viral genome, and influences UL138 expression. Inhibition of USP1 results in a failure to establish latency, marked by increased viral genome replication and production of viral progeny. Inhibition of Jak-STAT signaling also results in increased viral genome synthesis in hematopoietic cells, consistent with a role for USP1-mediated regulation of STAT1 signaling in the establishment of latency. These findings demonstrate the importance of the UL138-UAF1-USP1 virus-host interaction in regulating HCMV latency establishment through the control of innate immune signaling. It will be important going forward to distinguish roles of UAF1-USP1 in regulating pSTAT1 relative to its role in the DNA damage response in HCMV infection.
Viral proteogenomic and expression profiling during productive replication of a skin-tropic herpesvirus in the natural host
Authors: Volkening Jeremy D. , Spatz Stephen J. , Ponnuraj Nagendraprabhu , Akbar Haji , Arrington Justine V. , Vega-Rodriguez Widaliz , Jarosinski Keith W.
Published: June 2023

Efficient transmission of herpesviruses is essential for dissemination in host populations; however, little is known about the viral genes that mediate transmission, mostly due to a lack of natural virus-host model systems. Marek’s disease is a devastating herpesviral disease of chickens caused by Marek’s disease virus (MDV) and an excellent natural model to study skin-tropic herpesviruses and transmission. Like varicella zoster virus that causes chicken pox in humans, the only site where infectious cell-free MD virions are efficiently produced is in epithelial skin cells, a requirement for host-to-host transmission. Here, we enriched for heavily infected feather follicle epithelial skin cells of live chickens to measure both viral transcription and protein expression using combined short- and long-read RNA sequencing and LC/MS-MS bottom-up proteomics. Enrichment produced a previously unseen breadth and depth of viral peptide sequencing. We confirmed protein translation for 84 viral genes at high confidence (1% FDR) and correlated relative protein abundance with RNA expression levels. Using a proteogenomic approach, we confirmed translation of most well-characterized spliced viral transcripts and identified a novel, abundant isoform of the 14 kDa transcript family via IsoSeq transcripts, short-read intron-spanning sequencing reads, and a high-quality junction-spanning peptide identification. We identified peptides representing alternative start codon usage in several genes and putative novel microORFs at the 5’ ends of two core herpesviral genes, pUL47 and ICP4, along with strong evidence of independent transcription and translation of the capsid scaffold protein pUL26.5. Using a natural animal host model system to examine viral gene expression provides a robust, efficient, and meaningful way of validating results gathered from cell culture systems.
The host phylogeny determines viral infectivity and replication across Staphylococcus host species
Authors: Walsh Sarah K. , Imrie Ryan M. , Matuszewska Marta , Paterson Gavin K. , Weinert Lucy A. , Hadfield Jarrod D. , Buckling Angus , Longdon Ben
Published: June 2023

Virus host shifts, where a virus transmits to and infects a novel host species, are a major source of emerging infectious disease. Genetic similarity between eukaryotic host species has been shown to be an important determinant of the outcome of virus host shifts, but it is unclear if this is the case for prokaryotes where anti-virus defences can be transmitted by horizontal gene transfer and evolve rapidly. Here, we measure the susceptibility of 64 strains of Staphylococcaceae bacteria (48 strains of Staphylococcus aureus and 16 non-S. aureus species spanning 2 genera) to the bacteriophage ISP, which is currently under investigation for use in phage therapy. Using three methods–plaque assays, optical density (OD) assays, and quantitative (q)PCR–we find that the host phylogeny explains a large proportion of the variation in susceptibility to ISP across the host panel. These patterns were consistent in models of only S. aureus strains and models with a single representative from each Staphylococcaceae species, suggesting that these phylogenetic effects are conserved both within and among host species. We find positive correlations between susceptibility assessed using OD and qPCR and variable correlations between plaque assays and either OD or qPCR, suggesting that plaque assays alone may be inadequate to assess host range. Furthermore, we demonstrate that the phylogenetic relationships between bacterial hosts can generally be used to predict the susceptibility of bacterial strains to phage infection when the susceptibility of closely related hosts is known, although this approach produced large prediction errors in multiple strains where phylogeny was uninformative. Together, our results demonstrate the ability of bacterial host evolutionary relatedness to explain differences in susceptibility to phage infection, with implications for the development of ISP both as a phage therapy treatment and as an experimental system for the study of virus host shifts.
Fundamentos aristotélicos de justicia y el principio de la precaución ambiental en tiempos de crisis pandémica en Brasil
Authors: Da Penha de Mendonça Coelho Bruna
Published: June 2023

El objetivo de este artículo es analizar los posibles puntos de aproximación entre los fundamentos de la concepción aristotélica de justicia y los presupuestos axiológicos del principio de la precaución en el derecho ambiental. Teniendo en cuenta este objetivo, el texto se divide en tres ejes: (i) recuperación teórica de las relaciones entre justicia, ética y naturaleza en Aristóteles; (ii) análisis conceptual del principio de la precaución, sus presupuestos de aplicación y aspectos actuales en el escenario de la crisis pandémica del COVID-19 en Brasil; (iii) investigación de las relaciones entre dicho principio y las dimensiones de la obra aristotélica. La conclusión resume los principales argumentos y resultados observados a lo largo del artículo.
Ana Maria Machado: pasión por la escritura
Authors: Rivas Hernández Ascensión
Published: June 2023

Ana Maria Machado, una de las grandes escritoras brasileñas contemporáneas, explica en esta entrevista aspectos relacionados con tres facetas importantes de su trayectoria profesional: su exilio en Europa a principios de los años 70, su escritura para niños y jóvenes y sus novelas para adultos, todo aquello que la ha llevado a ser una autora tan leída dentro y fuera de Brasil.
Pemanfaatan Data Satelit Radar untuk Wilayah Darat di Indonesia: Peluang dan Tantangan
Authors: Dony Kushardono  , Rahmat Arief
Published: June 2023

Peluang pemanfaatan data satelit radar atau Synthetic Aperture Radar (SAR) di Indonesia cukup tinggi karena kemampuan data satelit SAR yang dapat menembus awan, yang sering menjadi kendala dalam pemantauan permukaan bumi menggunakan data satelit optik. Selain itu, kelebihan data satelit radar ini dapat memantau permukaan tanpa gangguan cuaca serta dapat digunakan dalam kondisi siang dan malam. Untuk itu, pemanfaatan penginderaan jauh untuk berbagai kebutuhan dengan menggunakan data satelitSAR diperkirakan akan meningkat pada masa mendatang. Dalam rangka meningkatkan minat pengguna data satelit SAR dan menggali metode pemanfaatan data SAR di Indonesia, melalui bunga rampai ini disusun buku pemanfaatan data SAR di Indonesia yang menjelaskan status teknologi hingga pemanfaatannya untuk pertanian, perkebunan, dan monitoring lingkungan. Dengan hadirnya buku ini, diharapkan bisa menjadi salah satu referensi terkait teknologi dan pemanfaatan data satelit radar bagi para pengguna dan peneliti atau perekayasa dalam memajukan dan memanfaatkan teknologi data penginderaan jauh satelit radar secara optimal.
Infraestructuras de transporte y disputas territoriales: La IIRSA en Santa Fe
Authors: Szupiany Estefanía
Published: June 2023

Libro de:

Álvaro Álvarez. Ciudad Autónoma de Buenos Aires – Tandil: CLACSO - Universidad Nacional del Centro de la Provincia de Buenos Aires. 2021. 1° Edición. 419 pp. ISBN 978-987-722-985-1
DECONSTRUCTING CULTURAL STEREOTYPES TO UNCOVER HIDDEN TOURISM POTENTIALS
Authors: Firdaus Dwi Rini Sovia , Martha Layung Paramesti , Duryatmo Sardi
Published: June 2023

People of Minangkabau descent in Indonesia have several negative stereotypes that have long developed in society. Not only can it disturb the psychological condition of these ethnic group members, but it can also trigger intercultural conflict. This condition does not help the local government promote West Sumatra as a cultural tourism destination. This study deconstructs the negative stereotypes in order to correct misperceptions that have occurred so far. The study tests Hofstede’s cultural dimensions in two ways; first is towards the deconstruction process of Minangkabau’s original traditional teachings. The second is towards the nuclear family configuration using ANOVA test to find the shifting cultural values. This study attempts to find the origin of the negative stereotypes and confirm it with the original traditional teachings. This study can ward off bad cultural stereotypes as it corrects misconceptions about the nature of the matrilineal Minangkabau culture. Besides elaborating on the cause of negative stereotypes, this study also finds out the origin of positive ones. They are known to have high social awareness, strong entrepreneurial abilities, and excellent leadership skills. Thanks to these three good stereotypes, the Minangkabau people can then produce crafts that are intelligent and timeless, such as the production of engravings on songket cloth that are full of philosophy, the architectural feature of the Bagonjong house roof, the traditional dress, culinary menus, music, and art. This research produces data artifacts about contemporary Minangkabau culture to benefit the cultural tourism industry. This deconstruction approach has never been tested on the Minangkabau tribe.
CONFLICT AND CULTURAL ADAPTATION OF THE ACEH ROHINGYA REFUGEES IN MEDIA OPINION
Authors: Usman Abdul Rani , Sulaiman Azman , Muslim Muslim , Zulyadi Teuku
Published: June 2023

Increased political interests in a nation may lead to isolated citizens and conflicts of interest; so that ethnic minorities are oppressed, such as the Rohingya ethnic group in Myanmar. The Rohingya group as a minority in Myanmar, who fled to save themselves in Southeast Asia, were stranded in Aceh almost every year. The process of rescuing and sheltering the Rohingya refugees in Aceh experienced various problems, and one of them was cultural conflicts between the Rohingya refugees and the Acehnese people. The theory used in this study was a symbolic interaction with a descriptive qualitative method, and to understand the Rohingya issues through the mass media, the researchers used the media as data sources. The results of this study revealed that the Acehnese people were eager to save the Rohingya refugees due to religious similarities. Likewise, the regional government in coordination with the central government was also willing to save them on humanitarian grounds. In addition, UNHCR and volunteers from various organizations and non-governmental organizations were also working to serve and taking care of the needs of the Rohingya refugees. There were cultural conflicts between the Acehnese people and the Rohingya refugees due to cultural differences and mutual misunderstanding between their cultures. However, cultural adaptation could occur properly so that the refugees could survive and be comfortable in their daily lives in refugee camps. Cultural differences were an obstacle in the adaptation of the refugees in Aceh, but the similarity of religion was one of the factors of the cultural adaptation.
WOMEN'S ANNIHILATION IN KIDS TV SHOW “SI BOLANG”
Authors: Roromari Mazda Radita
Published: June 2023

Si Bolang has aired in Trans7 since 2006 and achieved various awards as a kids-friendly show. However, this show never showed a girl as its main character and limited the appearance of women or girls. The contents of Si Bolang become a discourse representation of its producer. This research reviewed the women's discourse in the Si Bolang by elaborating on the screen's symbolic annihilation of girls and women. This research used Norman Fairclough's critical discourse analysis method to analyze through three dimensions: text, discourse practice, and social praxis. This research analyzed the full episode of Si Bolang uploaded on YouTube by the official account of Trans7. The perspective framework used in this research is the symbolic annihilation of Gaye Tuchman. The text analysis shows that there are absences of women or girls. They have a limited appearance and only appear in the domestic realm, which is also a form of trivialization. There are discourse practices of femininity, mothering, the culture of domesticity, and the division of work in the hunting-gathering society that influence Si Bolang's content. Women's annihilation and role restriction of women on the screen shows that Si Bolang formed from patriarchal discourse. This discourse tends to eliminate and limit women's role in society. Researchers need to review women's discourse in TV or other media kids' shows to encourage gender equality in Indonesia's media.
Practice Theory as a Tool for Critical Social Theory
Authors: Haslanger Sally
Published: June 2023

What is the best method for undertaking critical social theory, and what are its ontological and normative commitments? Andreas Reckwitz has developed compelling answers to these questions drawing on practice theory. As a practice theorist myself, I am very sympathetic to his approach. This paper sketches a social theory that extends the reach of practice theory to include non-human animals and allows us to discriminate between importantly different kinds of social formations. In doing so, I argue that a strongly normative basis for differentiating social phenomena is compatible with the methods of social theory and critical social theorists need not shy away from first-order moral commitments.
The Society of Singularities: Reply to Four Critics
Authors: Reckwitz Andreas
Published: June 2023

In this article, Andreas Reckwitz replies to the four critical commentaries of Patrick Baert, Andreas Pettenkofer, Austin Harrington and Sally Haslanger on his book The Society of Singularities. In this context, he discusses the general position of this book within the landscape of contemporary social theory and the question of what a ‘social logic of the unique’ means. He enters the question in how far his analysis of the new middle class differs from Pierre Bourdieu’s analysis of the new petty bourgeoisie, emphasizing the combination of an orientation towards inner experience and social prestige in his account of the new middle class. He discusses the question of whether neoliberalism is responsible for the proneness to disappointment which the late-modern culture of self-actualization implies. Finally, he works out the differences between the type of critical analytics which his book implies and normative critical theory.
Ethics and Affect in Resistance to Democratic Regressions
Authors: Wolkenstein Fabio
Published: June 2023

In recent times, it has become increasingly common that elected parties and leaders systematically undermine democracy and the rule of law. This phenomenon is often framed with the term democratic backsliding or democratic regression. This article deals with the relatively little-studied topic of resistance to democratic regressions. Chief amongst the things it discusses is the rather central ethical issue of whether resisters may themselves, in their attempts to prevent a further erosion of democracy, transgress democratic norms. But the argument advanced in the article is not merely about the ethics of resistance. It begins, perhaps unconventionally, by addressing the affective dimension of resistance to democratic regressions, looking in particular at the powerful feelings of anger and despair that pro-democratic citizens living under a regressive government are likely to experience. As the article argues, these feelings have not only motivational but also epistemic potential, which must be adequately theorized in order to understand how resisters can respond to the ethical challenges facing them.
Peace through Justice, Truth, Reparation and Non-Repetition: Normative and Judicial Developments of the Special Legal Framework of Transitional Justice in Colombia
Authors: Perona Riccardo , Florez Muñoz Daniel Eduardo , Luna Salas Fernando
Published: June 2023

The paper addresses the fundamental aspects of transitional justice in Colombia, within the legal framework developed to obtain peace and considering the broad case law of the Colombian Constitutional Court on the matter. To this end, after laying down some foundations concerning the scope of the constitutional principle of “peace” in the Colombian legal order and the concepts of justice, truth, reparation and guarantee of non-repetition, the study focuses on the legislative and judicial developments that have characterized the process, starting from its very beginning up until the report of the Commission for the Clarification of the Truth in 2022.
Measurement of surface vibration signal of 500 kV transformer and analysis of its frequency characteristics
Authors: Dai Lili , Zhang Guangyong , Guo Jinqin , Li Yongwei
Published: June 2023

By measuring and analyzing the vibration signals of the transformer core and windings, the operating conditions of the transformer can be diagnosed. In this paper, the surface vibration signals of 500 kV autotransformer with different structures are measured, and the frequency domain characteristics of the surface vibration signals are analyzed. The blind source separation algorithm is used to separate the surface vibration signals and obtain the vibration signals of core and winding respectively, which provides strong data support for further condition evaluation and fault diagnosis of the core and winding using their vibration signals. Firstly, the surface vibration signal measuring points are set according to the specific arrangement of the core and winding of the transformer; secondly, the vibration signals of different vibration measuring points of the transformer under the same load and different loads of the same vibration measuring point are measured respectively; finally, the frequency characteristics of the measured vibration signals are compared and analyzed. Then, use blind source separation algorithm for transformer surface vibration signal processing, the two signals obtained are close to the vibration characteristics of core and winding respectively, and the separated, it is proved that the accurate vibration signals of core and winding can be obtained by blind source separation, it is helpful for further analysis of the operation state of the core and winding.
Random and block architectures of N-arylitaconimide monomers with methyl methacrylate
Authors: Deoghare Chetana
Published: June 2023

“Itaconimide” is the members of imide (–CO–NH–CO–) family with reactive exocyclic double bond and it is easily obtained from the renewable resource i.e. D-glucose. The polymerization of various N-arylitaconimide (NAI) monomers with methyl methacrylate (MMA) have been reported to improve the glass transition temperature (T
g) and thermal stability of poly(methyl methacrylate) (PMMA). In literature, these studies have been done mostly using conventional free radical polymerization methods, which restricts the architecture of copolymers to “random” only. The block copolymers of NAI and MMA are an important due to the combination of glassy PMMA and thermally stable poly(NAI), which offers its applications for higher temperature service. The architectural control of polymers in provisions of its topology, composition, and various functionalities is possibly obtained using reversible-deactivation radical polymerizations (RDRPs). In RDRPs, the concentration of free radical is controlled in such a way that the termination reactions are minimized (normally in range of 1–10 mol%), and not allowed to obstruct with the desired architecture. However, this is possible by achieving (or by establishing) a rapid dynamic equilibrium between propagating radical and dormant species (i.e. R–X). Among all RDRPs, the atom transfer radical polymerization (ATRP) is very popular and adaptable method for the synthesis of polymers with specifically controlled architecture. Two different architectures of NAI and MMA copolymers are reported using ATRP process. The effect of various pedant groups on the rate constants of propagation (k
p) and thermal properties NAI and MMA copolymers is studied. The poly(NAI-ran-MMA)-b-poly(MMA) are stable up to 200 °C and degraded in three steps. Whereas, the poly(NAI-ran-MMA)-b-poly(NAI) are stable up to 330 °C and degraded in two steps. The density functional theory methods are used for calculation of equilibrium constants (K
ATRP) for the ATRP process for the series of laboratory synthesized alkyl halides. A good agreement was observed between the experimentally determined and theoretically calculated K
ATRP values. The mechanistic studies are carried for poly(NAI-ran-MMA) copolymer system using statistical model discrimination method along with 1H decoupled 13C NMR spectroscopy. For studying the mechanism of copolymerization of NAI and MMA via ATRP methods, “trimer model or penultimate model” will be more accurate than “dimer model or terminal model”.
Einkommensheterogenität und Rentenprognosen
Authors: Rausch Johannes
Published: June 2023

Simulationsmodelle der Gesetzlichen Rentenversicherung (GRV) berücksichtigen die Heterogenität des Versichertenbestandes bisher kaum. Insbesondere die Einkommensheterogenität blieb bislang außen vor. In diesem Beitrag erweitert Johannes Rausch daher zunächst das Rentensimulationsmodell MEA-PENSIM um eine differenzierte Betrachtung der Einkommenssituationen, um anschließend deren Bedeutung für die künftige Entwicklung der GRV anhand von ausgewählten Anwendungen zu bewerten. Dies umfasst unter anderem die Betrachtung einkommensspezifischer Lebenserwartungen, einkommensabhängiger Ersatzraten sowie einer Kaufkraftdynamisierung der Bestandsrenten. Die Einkommensdifferenzierung erfolgt anhand administrativer Daten der GRV. Es zeigt sich, dass die Berücksichtigung einkommensspezifischer Unterschiede (beispielsweise hinsichtlich des Renteneintrittsverhaltens) die Modellgüte erhöht. Darüber hinaus liefert die differenziertere Betrachtung zusätzliche Erkenntnisse, insbesondere zu den Ersatzraten der unteren Einkommensgruppen. Ganz allgemein kann das Modell nun die Verteilungseffekte von Rentenreformen simulieren. Das gilt besonders für die Bewertung von Reformen, die das Äquivalenzprinzip durch mehr Umverteilung aufweichen.
The role of pain modulation pathway and related brain regions in pain
Authors: Yao Dandan , Chen Yeru , Chen Gang
Published: June 2023

Pain is a multifaceted process that encompasses unpleasant sensory and emotional experiences. The essence of the pain process is aversion, or perceived negative emotion. Central sensitization plays a significant role in initiating and perpetuating of chronic pain. Melzack proposed the concept of the “pain matrix”, in which brain regions associated with pain form an interconnected network, rather than being controlled by a singular brain region. This review aims to investigate distinct brain regions involved in pain and their interconnections. In addition, it also sheds light on the reciprocal connectivity between the ascending and descending pathways that participate in pain modulation. We review the involvement of various brain areas during pain and focus on understanding the connections among them, which can contribute to a better understanding of pain mechanisms and provide opportunities for further research on therapies for improved pain management.
Zero affixes in derivational morphology: Introduction
Authors: Iordăchioaia Gianina , Melloni Chiara
Published: June 2023

In this paper we offer an overview of the linguistic phenomena that have traditionally been handled by means of zero affixes and of the theoretical debate around the advantages and disadvantages of employing such null morphemes in theoretical modeling. While the advantage of positing zero affixes is straightforward from an empirical perspective (see inflectional syncretism and affixless category change, among others), their theoretical legitimacy has been controversially debated for several decades. In this overview, we present the main problems that have been brought forward against zero affixation and some of the mechanisms that have been proposed as an alternative. Finally, we show how the different articles in our edited collection contribute to this debate by addressing the following three research questions: (1) How do current theories of derivational morphology deal with linguistic phenomena that seem to involve zero affixes? (2) How do zero derivational affixes compare with their “overt analogues” (i. e. overt derivational affixes)? (3) What insights can we obtain from language-specific properties, typological generalizations and/or larger data-oriented studies on the question whether zero affixation is necessary in derivational morphology?
Verb-to-noun conversion in Polish: Multiple schemas in Construction Morphology
Authors: Cetnarowska Bożena
Published: June 2023

This article shows that deverbal conversion nouns in Polish fall into several classes, depending on their inflectional properties and on their semantic interpretation, e. g.rzut‘throw’,rząd‘government’,odnowa‘renovation’, andprzystań‘haven, wharf’. In a theoretical framework which recognizes zero morphemes as nominalizers, such a situation would call for the recognition of many homonymous zero affixes (each specifying a distinct inflection class or a different semantic paraphrase of the resulting zero-derivative). It is argued here that a more felicitous account of this type of verb-to-noun derivation in Polish can be offered in the framework of Construction Morphology. It involves the postulation of multiple construction schemas which express the form-meaning correspondence observable in various subtypes of conversion nouns. Such low-level schemas are treated as instantiations of more general (high-level) schemas and they form a network of morphological constructions in a hierarchical lexicon.
Zero suffixes in Modern Greek derived adjectival formations with alpha privative
Authors: Koutsoukos Νikos , Ralli Angela
Published: June 2023

In this paper, we examine Modern Greek adjectives with the negative prefixα- [a] (also calledalpha privative) which are derived from nouns. These formations display formal and semantic properties that cannot be attributed to any overt element of the structure. Following a bottom-up approach, we revisit the question of whether zero morphemes are useful in the realm of derivational morphology. We argue for a zero derivational suffix that accounts for the lexical category and the inflectional properties of the formation and in combination with the negative prefixa- gives a privative reading. As this zero suffix attributes the basic properties of the formations, but it is not part of the overt structure, we raise the question of whether derivational structures can also be exocentric. Many scholars have claimed that exocentricity is a property pertinent only to compounds. However, we argue that there is no reason why the presence of zero morphemes and the notion of exocentricity should be excluded from derivational morphology.
Distinct Features of Interictal Activity Predict Seizure Localization and Burden in a Mouse Model of Childhood Epilepsy
Authors: Tobin William F. , Weston Matthew C.
Published: June 2023

The epileptic brain is distinguished by spontaneous seizures and interictal epileptiform discharges (IEDs). Basic patterns of mesoscale brain activity outside of seizures and IEDs are also frequently disrupted in the epileptic brain and likely influence disease symptoms, but are poorly understood. We aimed to quantify how interictal brain activity differs from that in healthy individuals, and identify what features of interictal activity influence seizure occurrence in a genetic mouse model of childhood epilepsy. Neural activity across the majority of the dorsal cortex was monitored with widefield Ca2+imaging in mice of both sexes expressing a humanKcnt1variant (Kcnt1m/m) and wild-type controls (WT). Ca2+signals during seizures and interictal periods were classified according to their spatiotemporal features. We identified 52 spontaneous seizures, which emerged and propagated within a consistent set of susceptible cortical areas, and were predicted by a concentration of total cortical activity within the emergence zone. Outside of seizures and IEDs, similar events were detected inKcnt1m/mand WT mice, suggesting that the spatial structure of interictal activity is similar. However, the rate of events whose spatial profile overlapped with where seizures and IEDs emerged was increased, and the characteristic global intensity of cortical activity in individualKcnt1m/mmice predicted their epileptic activity burden. This suggests that cortical areas with excessive interictal activity are vulnerable to seizures, but epilepsy is not an inevitable outcome. Global scaling of the intensity of cortical activity below levels found in the healthy brain may provide a natural mechanism of seizure protection.

SIGNIFICANCE STATEMENTDefining the scope and structure of an epilepsy-causing gene variant's effects on mesoscale brain activity constitutes a major contribution to our understanding of how epileptic brains differ from healthy brains, and informs the development of precision epilepsy therapies. We provide a clear roadmap for measuring how severely brain activity deviates from normal, not only in pathologically active areas, but across large portions of the brain and outside of epileptic activity. This will indicate where and how activity needs to be modulated to holistically restore normal function. It also has the potential to reveal unintended off-target treatment effects and facilitate therapy optimization to deliver maximal benefit with minimal side-effect potential.
Inovasi Media Pembelajaran Sejarah Lokal Ki Gede Sebayu Melalui Platform TikTok
Authors: Septiyaningsih Imada Cahya , Waskito Hibatullah Habil
Published: June 2023

Kabupaten Tegal memiliki cukup banyak peristiwa masa lampau yang bersemayam di dalamnya. Namun sayangnya, kini banyak generasi muda yang belum mengetahui mengenai sejarah lokal yang berada di daerahnya, sehingga nilai-nilai kearifan lokal yang terkandung di dalam sejarah masih belum tersampaikan secara maksimal. Dalam pembelajaran sejarah, khusunya mengenai Ki Gede Sebayu, erat kaitannya dengan pendidikan karakter, sehingga dengan mempelajari sejarah Ki Gede Sebayu harapannya dapat menyampaikan nilai-nilai karakter yang terkandung di dalamnya. Namun, anggapan bahwa belajar sejarah itu membosankan masih sering ditemui di sebagian generasi muda, sehingga hal ini bisa yang kerap menjadi penghambat generasi muda untuk mempelajari sejarah Ki Gede Sebayu. Maka dari itu, Penulis ingin membuat sebuah inovasi pembelajaran sejarah yang lebih menarik. Berdasarkan konteks permasalahan yang dikaji peneliti, penelitian ini menggunakan metode kualitatif berdasarkan kajian kepustakaan serta bersifat eksploratif dan evaluatif. Penelitian eksploratif dilakukan dengan tujuan mengetahui informasi yang lebih jauh dan lebih dalam mengenai sejarah Ki Gede Sebayu yang akan diimplementasikan dalam platform TikTok. Hasil dari inovasi media pembelajaran tersebut dapat memotivasi peserta didik untuk mempelajari sejarah lokal Ki Gede Sebayu.

Kata kunci: sejarah lokal, pendidikan karakter, platform TikTok

Tegal Regency has a rich history with numerous past events embedded within it. Unfortunately, many young people are currently unaware of the local history in their area. As a result, the valuable lessons and wisdom encompassed in this history are not being optimally conveyed. Learning about history, particularly regarding Ki Gede Sebayu, is closely intertwined with character education. By studying the history of Ki Gede Sebayu, it is hoped that the character values embedded therein can be effectively communicated. However, the notion that studying history is boring remains prevalent among some of the younger generation, thereby hindering their exploration of Ki Gede Sebayu's history. Consequently, the authors aim to introduce a more captivating approach to history education. In accordance with the research problems, this study employs qualitative methods based on a literature review, encompassing exploratory and evaluative aspects. The exploratory research phase was conducted to gather comprehensive and in-depth information about the history of Ki Gede Sebayu, which will be implemented on the TikTok platform. The outcome of this innovative learning media is expected to motivate students to engage with the local history of Ki Gede Sebayu.

Keywords: local history, character education, TikTok platform
Promoting Students' Science Process Skills Through Predict Discuss Explain Observe Discuss Explain Implementation
Authors: Hardianti Risa Dwita , Permatasari Indhah Ulya
Published: June 2023

The ideal science classroom prepares students to enhance not only mastery knowledge but also skills. Certain skills can be developed during the process of learning science. One of the skills that expected to be possessed is Science Process Skills (SPS). SPS can be gain by applying Predict-Discuss-Explain-Observe-Discuss-Explain (PDEODE). Therefore, the intent of this study was analyzing students’ science process skills after the implementation of PDEODE. Measurements of SPS were obtained by collecting data from three domains of learning. SPS of students ranges from good to excellent level. About 18,29% students got excellent marks of SPS while most of them (81,71%) successfully reached good level. To put in a nutshell, PDEODE learning assisted students to attain all indicators of SPS.
Science Around Us: Development of a Community-based Science Curriculum for Local Preschools in the Philippines
Authors: Pawilen Greg Tabios
Published: June 2023

Teaching science for preschool children is essential in setting the foundation for science literacy and in kindling young children’s interest in learning science. Hence the goal for designing a culturally relevant science curriculum is a gigantic challenge to all preschool teachers. This study proposed a community-based science curriculum for local preschools in northern Philippines. It supports the idea that nature should be utilized in nurturing the interest of young children in learning science. Qualitative method was used in gathering data from parents, teachers, and community leaders. Community resources that could be utilized for learning scince were identified, the legal framework for preschool education was analyzed, and the current national curriculum standards for kindergarten was analyzed to design and develop a science-based curriculum for young children. The result, which is a proposed curriculum, integrates cultural scripts, indigenous knowledge and practices, learners’ interests and needs, and community resources in the selection of curriculum contents and learning experiences. The proposed community-based science curriculum could be a model for developing a culturally relevant and responsive education for indigenous people.
The changing landscape of automated insulin delivery in the management of type 1 diabetes
Authors: Lakshman Rama , Boughton Charlotte , Hovorka Roman
Published: June 2023

Automated insulin delivery systems, also known as closed-loop or ‘artificial pancreas’ systems, are transforming the management of type 1 diabetes. These systems consist of an algorithm which responds to real-time glucose sensor levels by automatically modulating insulin delivery through an insulin pump. We review the rapidly changing landscape of automated insulin-delivery systems over recent decades, from initial prototypes to the different hybrid closed-loop systems commercially available today. We discuss the growing body of clinical trials and real-world evidence demonstrating their glycaemic and psychosocial benefits. We also address future directions in automated insulin delivery such as dual-hormone systems and adjunct therapy as well as the challenges around ensuring equitable access to closed-loop technology.
Benign tumours of foot and ankle
Authors: Fritzsche Hagen , Weidlich Anne , Schaser Klaus-Dieter , Mehnert Elisabeth , Winkler Doreen , Rammelt Stefan
Published: June 2023

Musculoskeletal tumours of foot or ankle make up about 4–5% of all musculoskeletal tumours. Fortunately, about 80% of them are benign. However, due to the rarity and low prevalence of each single tumour entity, diagnosis is often difficult and delayed.

Ultrasonography is an important diagnostic tool to safely recognize ganglion cysts as a frequently encountered ‘bump’ in the foot.

In suspicious lesions, malignancy must be excluded histologically in a tumour center by biopsy after imaging procedures using x-ray, computed tomography (CT) and magnetic resonance imaging (MRI).

Most of the benign tumours do not require any further surgical therapy. Resection should be performed in the case of locally aggressive tumour growth or local symptoms of discomfort. In contrast to malignant tumours, the primary purpose in the resection is the least possible loss of function.
Morfopotencialidad de los percutores-retocadores del nivel XIII de la Cueva de El Esquilleu (Cantabria)
Authors: Nebot Ibáñez Ana
Published: June 2023

El nivel XIII de la Cueva del Esquilleu, en cuanto a industria lítica y a esquemas tecnológicos, se puede definir como un nivel con predominio de debitage Quina. Aparece también una representación (en menor medida) de debitage Levallois y distintos tipos de útiles (denticulados, raederas…).Se define como un “nivel quina” por el alto porcentaje de raederas quina, lascas características de este esquema de talla, lascas de reavivado de distintos tamaños, es decir, de distintos momentos del proceso de reavivado, que se han recuperado en el transcurso de la excavación. La materia prima dominante es la cuarcita (grano fino, medio o grueso), pero también aparece material en sílex, cristal de roca y nódulo ferruginoso (lutita).En cuanto al instrumental de percusión, se han recuperado alrededor de cincuenta percutoresretocadores en el área hasta ahora excavada, que podrían estar asociados al proceso de debitage quina. Se caracterizan por ser, en su mayoría, cantos de arenisca planos, aunque aparecen también de cuarcita, en número muy reducido, pero con las mismas características morfológicas.
La funcionalidad de las puntas de pizarra talladas
Authors: Malagón García Marta
Published: June 2023

El presente trabajo estudia la funcionalidad de puntas de pizarra tallada a partir del hallazgo de puntas de pizarra en el yacimiento zamorano de El Santuario de San Martín de El Pedroso.El yacimiento calcolítico de El Pedroso se sitúa en la comarca de Aliste y se caracteriza por la calidad de la cultura material y por la monumentalidad de sus estructuras.Es un yacimiento en altura, con gran dominio del espacio que le rodea. Su situación sobre un inselberg granítico le permite una fácil defensa, que se consigue en parte gracias a los farallones rocosos que llegan a formar grandes murallas naturales. También se caracteriza por la abundancia de pizarra en la zona. Hay que destacar los numerosos abrigos graníticos que se relacionan con enterramientos de las gentes de El Pedroso y en algunos casos con grabados rupestres.
Method of clusterization of c6 coal seam zones of different thickness in the Dniprovska mine field by germanium concentration
Authors:   Institute of Geotechnical Mechanics named by N. Poljakov of the National Academy of Sciences of Ukraine, Ishkov Valerii , Kozii Yevhen ,   Dnipro University of Technology
Published: June 2023

In the article, based on the conducted research and analysis of the results of clustering, the most effective method of creating objective typification of zones of coal seam c6 of the Dniprovska Mine of different thickness according to germanium concentrations was established. The typification procedure is a systematization of objects according to a priori specified features. Cluster analysis, taxonomy, pattern recognition, and factor analysis are usually used for this purpose. The authors of the article carried out clustering using various methods implemented in the most different professional statistical software platforms, performed their analysis and justified the choice of the most optimal of them. The optimal method of clustering areas of different thicknesses of the coal seam was determined. The analysis of the dendrogram of the results of clustering by the weighted centroid-median method of the sites of the c6 seam by germanium content, unlike others, allows not only to achieve the most stable division of the entire set of sites under consideration, but also to maximize the visualization of their division by classes at different scale levels in the absence of a priori hypotheses regarding the number clusters and their forms. At the same time, the structure of clusters is clearly distinguished, regardless of the scale level of their formation, and the sequence of combining individual deposits and their groups into the resulting cluster is clearly traced. These advantages make it possible to make maximum use of already existing information for the development of natural typifications of с6 coal seam areas by germanium content and to interpret the obtained results in geological terms. It was established that the weighted centroid median method of cluster analysis is the most optimal for the subjectivity-free researcher to divide the sections of coal seam c6 of the Dniprovska Mine field according to germanium content into taxa. The constructed dendrograms of the clustering of deposits by germanium content can be used as a basis for the development of a natural typification of the coal seams of the Dniprovska Mine for their subsequent geological and economic assessment. This, in turn, will make it possible to make maximum use of already available information and interpret the obtained results in geological and genetic concepts, which will provide the opportunity to use it for the complex use of mineral raw materials and to solve strategic issues of sustainable development of Ukraine. Keywords: cluster analysis, coal seam, germanium, clusters, taxa, dendrogram of clustering results, weighted centroid method.