bluuebunny/crossref_metadata_2025 huggingface dataset:
LINFOMA COMO CAUSA DE FÍSTULA GASTROESPLÊNICA: RELATO DE CASO E REVISÃO INTEGRATIVA DA LITERATURA
Authors: Kallás Isabella de Oliveira , Faria Leticia Brito Del Picchia , Pereira Ana Paula Ribeiro do Valle , Borduchi Paulo Henrique Costa
Published: September 2024

Paciente , atendido no caráter de urgência no Hospital das Clínicas Samuel Libânio  com quadro de abdome agudo, em sepse. Apresentava lesão esplênica sem plano de clivagem com parede gástrica. Após avaliação optou-se por procedimento cirúrgico, que incluiu esplenectomia, gastrectomia parcial e linfadenectomia, seguida de confecção de jejunostomia à Stamm. Foi evidenciada fístula gastroesplênica, a qual é uma condição extremamente rara e potencialmente fatal, frequentemente associada a linfomas, especialmente os linfomas difusos de grandes células B. Paciente apresentou boa evolução clínica, com alta à oncologia clínica.
Social Media and Political Activism in India: A Content Analysis of Online Movements
Authors: Dr Manoj Kumar Sahu  , Dr. Tapesh Chandra Gupta
Published: September 2024

This research paper examines the role of social media in political activism in India by conducting a content analysis of tweets related to four significant online movements: #CAAProtests, #FarmersProtest, #MeTooIndia, and #LokSabhaElections2019. The study aims to explore how digital platforms like Twitter facilitate political engagement, shape public discourse, and influence broader societal outcomes. Using qualitative content analysis, data were collected through Twitter’s API, focusing on key hashtags from 2018 to 2023. The findings reveal that social media serves as a dynamic platform for political participation, enabling diverse engagement across linguistic and regional lines. Text-only tweets were the most common, but the substantial presence of images, memes, and videos underscores the role of visual content in enhancing public engagement. Sentiment analysis indicated a balanced distribution between positive, negative, and neutral sentiments, reflecting the complex nature of digital discourse. The study highlights the democratizing power of social media, allowing ordinary citizens, activists, and media to contribute to political narratives. However, challenges such as misinformation and limited depth of engagement were also noted. The research emphasizes the importance of social media in contemporary political landscapes, offering insights into how digital activism can influence public opinion and drive societal change.
Recommendation System based on Artist and Music Embeddings
Authors: Surolia Akshat
Published: September 2024

In this paper, we present a personalized music recommendation system based on the embeddings of artists and music. The main peculiarity of our work is that the determining factors of a user’s preferences for a developed music recommender system are the artists and the music that they listen to. The artist embeddings inform the network about the contextual representation of artists in a latent space, where similar artists are closer to each other. The music embeddings hold the information about the music. Both embeddings are then combined to form a new embedding, which is then used to predict the user’s preferences. We use the Spotify’s API to collect the data to train and evaluate the model. Two approaches of building a music recommender system are considered in this paper. Each approach significantly differs in the way the embeddings are learned.
Analisis Kemampuan Sains pada Aktivitas Eco Printing di PAUD
Authors: Ira Anggraeni
Published: September 2024

Penelitian ini mengeksplorasi dampak aktivitas Eco Printing terhadap kemampuan sains anak-anak usia dini di PAUD melalui pendekatan kualitatif studi kasus. Data diperoleh melalui observasi, wawancara dengan guru PAUD, dan interaksi langsung dengan anak-anak selama aktivitas Eco Printing. Hasilnya menunjukkan bahwa Eco Printing berpotensi meningkatkan pemahaman sains anak-anak, memperkuat prinsip-prinsip ilmiah seperti pengamatan dan eksperimen sederhana. Selain itu, anak-anak menunjukkan minat yang tinggi dan keterlibatan aktif dalam pembelajaran sains. Wawancara dengan guru PAUD menyoroti manfaat Eco Printing dalam pembelajaran yang menyenangkan sekaligus memperkenalkan pentingnya menjaga lingkungan. Temuan ini mendukung integrasi aktivitas berbasis lingkungan dalam kurikulum PAUD untuk mendukung pembelajaran sains yang bermakna. Penelitian ini memberikan kontribusi penting dalam memahami peran Eco Printing dalam meningkatkan kemampuan sains anak-anak di PAUD, dengan rekomendasi untuk memasukkan kegiatan berbasis lingkungan dalam kurikulum PAUD.
O Impacto da vulnerabilidade social como fator preponderante para o desenvolvimento de Patologias intestinais: Uma revisão de literatura
Authors: Kethely Batista Dilson Nycole , Erika Neumann Costa Katherine , Maria do Nascimento Hermes Leandro Alice , Dayane Mendes de Oliveira Santiago Barbosa Estefânia , Da Silva Bringel Isadora , Ferreira de Albuquerque Carvalho Roberta , Amorim Araujo Jaine , Guilherme Dorneles Ferraz João , Coimbra Batista Thaís , Naraiane Oliveira de Souza Lopes Silvia , Beatriz Viana Freitas Costa Lara , Cecília Guimarães Castelo Branco Sarah , Menezes Gashti Sarah , Regina Schmitz Acco Victória , Maria Andreoli Fellini Beatriz , Augusto da Silva Araújo Victor , Oliveira Fontenele Barcelos Janice , Gomes Pinheiro Amanda , Manoel Vasconcelos da Rocha Sérgio , Pereira da Silva Anderson Matheus
Published: September 2024

RESUMO: Os transtornos alimentares (TAs) são condições psiquiátricas complexas que afetam profundamente a saúde física e mental das pessoas. Caracterizados por comportamentos alimentares anormais e uma preocupação obsessiva com o peso e a aparência física, esses transtornos incluem anorexia nervosa, bulimia nervosa e transtorno de compulsão alimentar periódica. Objetivo: O objetivo deste artigo é avaliar de forma abrangente o impacto da vulnerabilidade social na prevalência e no tratamento dos transtornos alimentares, com ênfase na bulimia nervosaMetodologia: A pesquisa foi conduzida nas bases de dados Biblioteca Virtual em Saúde (BVS), PubMed e PsycINFO, utilizando descritores específicos em português e inglês, como "Bulimia nervosa", "Saúde mental", "Vulnerabilidade social", "Multidisciplinaridade", "Terapias comportamentais" e "Intervenção". Para ampliar e refinar os resultados da busca, foram aplicados operadores booleanos, combinando termos com "AND" e "OR".   Resultados e discussão: A desigualdade de gênero também desempenha um papel crucial na vulnerabilidade aos transtornos alimentares. As mulheres, especialmente aquelas em situação de vulnerabilidade social, são mais suscetíveis devido a expectativas culturais e sociais em relação à imagem corporal.  Conclusão: A implementação sistemas de monitoramento e avaliação contínua das intervenções terapêuticas para transtornos alimentares, com o objetivo de ajustar e melhorar as estratégias de tratamento conforme necessário, é essencial.
Impacto das técnicas cirúrgicas modernas na recuperação de pacientes pediátricos: uma análise atualizada
Authors: Silva Camila Azevedo , Borges Daniel Martins , Martins Isabella Pitote da Silva , Guerra Tarine Dinis Azevedo , Farias Estrela Cecília Moreira de Holanda
Published: September 2024

Este estudo realiza uma análise atualizada do impacto das técnicas cirúrgicas modernas, incluindo a cirurgia minimamente invasiva e a robótica, na recuperação de pacientes pediátricos. A pesquisa foi conduzida através de uma revisão sistemática da literatura, abrangendo artigos publicados entre 2015 e 2023. A análise revela que as técnicas minimamente invasivas e robóticas oferecem benefícios significativos em comparação com métodos tradicionais, destacando uma redução no tempo de recuperação, menor taxa de complicações e melhor controle da dor pós-operatória. Os dados mostram que a cirurgia minimamente invasiva proporciona uma diminuição de 30% no tempo de internação e uma recuperação mais rápida, enquanto a robótica cirúrgica resulta em uma redução de 25% no tempo de recuperação e maior precisão nos procedimentos complexos. A utilização de protocolos avançados de manejo pós-operatório e cuidados multidisciplinares também contribui para resultados mais positivos. No entanto, a implementação dessas técnicas pode enfrentar desafios relacionados a custos e necessidade de treinamento especializado. Os resultados indicam que as técnicas cirúrgicas modernas representam um avanço importante na prática cirúrgica pediátrica, promovendo uma recuperação mais eficiente e segura para os pacientes.
Avanços na gestão de doenças crônicas: uma revisão das estratégias atuais e suas implicações clínicas
Authors: Silva Camila Azevedo , Farias Estrela Cecília Moreira de Holanda , Schneider Felipe Fraga , Oliveira Heitor Rodrigues de , Alves Diego Almeida , Maymone Isabela de Campos , Borges Daniel Martins , Coelho Fernanda Pacheco Mendes , Martins Isabella Pitote da Silva , Guerra Tarine Dinis Azevedo
Published: September 2024

Este artigo revisa os avanços na gestão de doenças crônicas, destacando melhorias nas estratégias farmacológicas e não farmacológicas, e o impacto das tecnologias de saúde. A introdução de novos medicamentos com menos efeitos colaterais e intervenções como programas de modificação de estilo de vida têm melhorado o controle das condições crônicas. Tecnologias como dispositivos de monitoramento remoto e aplicativos móveis permitem um acompanhamento mais personalizado, embora enfrentem desafios de custo e acesso. As estratégias integradas melhoram a qualidade de vida dos pacientes, mas as desigualdades no acesso podem limitar esses benefícios. Futuras pesquisas devem explorar a eficácia das novas abordagens em diferentes contextos.
Curriculum Design for High School of Theology & Christian High School Based on Indonesian National Qualifications Framework (KKNI)
Authors: Oci Markus , Suparti Hana , Wahyuni Sri , Soeharto Daniel
Published: September 2024

Background. Higher education is a formal institution in government educational institutions. Higher education is expected to be a tool that assists everyone in obtaining adequate resources. As a result, understanding the system in a tertiary institution is critical in order to support the education system.
Purpose. The objective of this research was to help tertiary institutions understand their role in developing superior human resources by developing an IQF-based curriculum system that produces graduates that meet the needs of the community.
\Method. The descriptive qualitative method was used, along with a literature review.
Results. The author explained each of the findings using a literature review. According to the findings of this study, tertiary institutions’ High School of Theology & Christian High School must determine graduate profiles, graduate learning outcomes, study materials, course formation, course grouping, course structure provisions, and semester lesson plans in the lecture curriculum.
Conclusion. Each tertiary institution must pay attention to new systems in order to create superior human resources in their fields in order to advance the curriculum.
The Implementation of Teaching Speaking Using Think Talk Write (TTW) Strategy at the Third Level of Institut Prima Bhakti Pamekasan
Authors: Rizqi Hanifatur , Sumitro Eko Adi
Published: September 2024

Background. In teaching learning process of English courses, the teachers have an important role because they are the influential people in the class and students can learn from the teachers, while the teachers have to provide suitable learning system by using interesting instruction of the material and good method as a strategy to interest students. Think Talk Write (TTW) Strategy is one of the alternative methods in teaching learning process to increase students’ understanding and communicating that is based on comprehension that study is a social behavior. Therefore, this title is expected to inform about the implementation of Think Talk Write (TTW) Strategy in teaching learning English process especially in teaching speaking
Purpose. The researcher is interested to conduct the research for students at the third level of Institut Prima Bhakti Pamekasan in which an English teacher implements TTW Strategy in teaching speaking. The problems investigated in this study were the way to implement, the difficulties that faced by students and the ways to solve the students’ difficulties in teaching speaking using Think Talk Write (TTW) Strategy.
Method. In obtaining the data, the researcher used descriptive qualitative to describe all of the result of research and the data were gotten by observation to see the teaching speaking process in the class, interview to get supporting data and documentation as a proof to study the data. This research had done five times. The first, it was done on 27th September 2023, the second on 28th September 2023, the third on 5th October 2023, the fourth on 12th October 2023, and the fifth on 19th October 2023.
Results. The result of the study showed that in the implementation of teaching speaking used TTW strategy at the third level of Institut Prima Bhakti Pamekasan, the teacher introduced the topic at the first and asked the students to answer the problem of the topic individually (think phase), then discussed the topic in a group (talk phase) and wrote the result of discussion individually. The last, the teacher asked the students to present their answer to the other group that possible for other group gave consideration.
Conclusion. The students’ difficulties were they difficult to have understanding about the topic because they had no experience, they difficult to make sentences because they had little vocabularies and relate their opinion with other friends’ opinion in a group (talk phase).
Implementation of Character Education in Madrasah Aliyah in Era 5. 0
Authors: Patty Elyakim Nova Supriyedi , Sunardin Sunardin , Sutrisno Sutrisno , Ilmi Darul
Published: September 2024

Background. The 5.0 era generation is a generation that has developed knowledge of Information and Communication Technology (ICT). Some of the skills that students must have are: Productive thinking, innovative, artistic, mastery of communication and mastery of cooperation. Strengthening character education certainly needs to be realized, this aims to instill moral traits (ethical character) which makes morals an individual characteristic.
Purpose. The aim of this research is to understand the outline and system for determining character education for students at Madrasah Aliyah. Apart from that, this research also aims to explain to students what character education looks like in passing through the 5.0 education era.
Method. The method used is a quantitative survey model, a survey using online-based Google Form and in-depth interviews with students.   
Results. The results of the research can explain that the implementation of character education is actually very important to equip students for the future. Character education is implemented with a system that utilizes information technology available in schools, so that morals can be formed and at the same time can also develop mastery of skills in the field of ICT, think productively, innovatively and can be achieved by students in the future in the 5.0 era.
Conclusion. Research limitations that is, researchers cannot explain the overall implementation of character education for students at Madrasah Aliyah in depth and effectively. Researchers hope that future research can handle the implementation of character education for Madarasah Aliyah students in the 5.0 era well and more thoroughly.
Innovation in Qur'an Hadith Learning Media Through Audio Visual Media
Authors: Priyatno Dwi , Taufik Muhamad , Siregar Syahruddin , Syafiuddin Fauzan Azima , Guilin Xie
Published: September 2024

Background. Education is very important for all humans. There are so many learning media available for teachers and students. Educators and students can use one of these media, one of which is audio visual media. However, educators and students have not been able to use this audio visual media properly. Which by applying this audio visual media students are easier to understand learning.
Purpose. This study aims to find out how to use this audio visual media for learning Al Qur'an hadith.
Method. This research method uses quantitative methods and in-depth interviews. The results of this study are to find out the existence of teachers who apply audio visual media in learning Qur'an hadith, and there is an increase in student learning outcomes after the teacher applies this audio visual media.   
Results. This study explains that the role of audio-visual media in learning is very important, especially in learning Qur'an hadith.
Conclusion. Because the existence of audio-visual media is very helpful for teachers in learning Qur'an hadith so that students easily understand the lesson, and also improve student achievement.
The Impact of Covid-19 on Student Achievement in Higher Education
Authors: Hidajad Arif , Cale Woolnough , Jonathan Bouyea
Published: September 2024

Background. The Covid-19 pandemic has a huge impact on various fields, especially in the world of education. Learning that was originally carried out face-to-face becomes learning that is carried out online or online.
Purpose. Online learning has been approved by the government because it is one of the solutions to overcome the spread of the covid-19 virus. The purpose of this study is to be able to test the hypothesis regarding the impact of covid-19 on student achievement.
Method. The method used in this research is quantitative method, the data obtained through distributing questionnaires by utilising google from.  
Results. he results of this study indicate that lectures conducted online during covid-19 have a huge impact on the achievements obtained by students.
Conclusion. The conclusion of the study shows that there is a significant relationship between learning conducted online during the covid-19 pandemic and the learning achievements obtained by students.
Implementation of the MBKM Curriculum (Independent Learning Independent Campus) Towards the Islamic Religious Education Study Program at Higher College Level
Authors: SM Khairatunnimah. , Sari Reni Puspita , Solihah Arifatus
Published: September 2024

Background. Universities have so far implemented a credit learning system which is almost entirely dependent on classroom learning. This shows the low level of learning independence for students. Therefore, the idea of “Independent Learning Independent Campus” emerged, or "MBKM", and is currently a program of the Ministry of Education, Culture, Research and Technology of the Republic of Indonesia.
Purpose. This research aims to describe the implementation of the MBKM curriculum in Islamic religious education study programs in higher education. Based on data obtained from the official Ministry of Education and Culture website, it shows the rapid growth of universities implementing the MBKM program, from 576 universities in 2022 to 921 universities in 2023, or an increase of 60% per year.
Method. This type of research is library research. This research uses a content analysis method, namely a technique that identifies every word, sentence in a text or series of texts, concepts or themes. Meanwhile, the data sources used by researchers are books and research journals related to problem formulation.
Results. The research results show that the MBKM curriculum (Independent Learning Independent Campus) is a new curriculum that is still hotly discussed in higher education circles. With the inauguration of MBKM, every university must prepare everything to support the success of the program. Several universities still face several obstacles in their implementation, as seen at UIN Walisongo and Unida Gontor.
Conclusion. Thus, it is natural that every tertiary institution faces various difficulties in implementing MBKM. Therefore, universities must prepare well and hold outreach so that information can be widely accepted and understood by all parties, both lecturers and students.
Utilization of Facebook Group Application as an Online Learning Media in Akidah Akhlak Learning
Authors: Tanjung Muhamad Ali Hasymi Rafsanjani , Latipah Nur , Alfarezi Alfi
Published: September 2024

Background. Technology has an important role in learning media, including the use of Facebook Group applications as online learning media. This study focuses on learning Aqidah Akhlak at Darussalam Dharmasraya Islamic Boarding School.
Purpose. This study aims to explore the use of Facebook Groups as an online learning medium, identify the advantages and obstacles faced, and measure their effectiveness in increasing students' understanding of Aqidah Akhlak subjects.
Method. This research uses quantitative methods with survey models and in-depth interviews. The survey was conducted online with 20 teachers as respondents, and an in-depth interview was conducted with one of the teachers who used Facebook Groups in learning.
Results. The results showed that the use of Facebook Groups in learning Aqidah Akhlak was very effective. As many as 100% of teachers understand how to use this application, and 70% agree that Facebook Groups are very useful as a learning medium. However, there are several obstacles such as the need for internet quota and a stable network.
Conclusion. Facebook groups as online learning media are very helpful for the teaching and learning process, especially in increasing students' understanding and enthusiasm for learning. Despite some technical obstacles, the app remains an effective solution in distance learning. The research suggests that the use of Facebook Groups be further integrated into the learning curriculum to maximize the benefits of technology in education.
Analysis of the Tax System, Fairness and the Possibility of Fraud Detection on Perceptions of Tax Evasion
Authors: Sucipto Adi
Published: September 2024

Fraud behavior in taxation is a problem that often occurs, one of the acts of fraud committed is tax evasion. The impact of tax evasion itself raises many perceptions, especially individual taxpayers who are in KPP Pratama Soreang. The purpose of this study was to determine the effect of the taxation system, justice and the possibility of detecting fraud on perceptions of taxpayers about tax evasion. This research uses descriptive verification method with quantitative approach. Source of data used are primary data resulting from the distribution of questionnaires to taxpayers of 100 respondents. Based on the results of the study showed that partially the taxation and justice system did not significantly influence the perception of tax evasion. However, the possibility of partial fraud being detected has a significant negative effect on perceptions of tax evasion with indicators of tax rates imposed in Indonesia and stringent checks. From the results of the study it is expected that tax officials can improve the quality of audits because it can reduce tax evasion in KPP Pratama Soreang.
Critical Analysis of the Rejection of Richard Bell's Thoughts on the Translation of the Qur'an in the Context of Orientalism
Authors: Abiyusuf Ilham , Hafizi Muhammad , Pakhrurrozi Pakhrurrozi , Saputra Wahyu , Hermanto Edi
Published: September 2024

Background. Richard Bell, a prominent English orientalist, applied historical, linguistic, and critical analysis to study the Qur'an in its historical and cultural contexts. However, his approach faced rejection from Muslim scholars, who argue that Bell's method fails to capture the Qur'an's true meaning as divine revelation.
Purpose. This study examines the rejection of Richard Bell's approach by Muslim scholars and scientists, aiming to understand the key arguments behind their opposition and evaluate its alignment with Islamic principles of Qur'anic interpretation.
Method. A qualitative approach is used, employing document analysis to review literature on Bell's works and methods, as well as texts outlining the views of Muslim scholars on Qur'anic interpretation. The analysis focuses on identifying the points of rejection and evaluating the reasoning behind them.
Results Muslim scholars reject Bell's approach because they believe it lacks respect for the Qur'an as divine revelation. They argue that his focus on historical criticism overlooks the context of revelation and Prophet Muhammad's explanations. They see the Qur'an as a unified whole and question the applicability of Western academic methods to understanding religious texts. Ultimately, they find Bell's approach incompatible with Islamic principles of interpretation.
Conclusion. Muslim scholars reject Richard Bell's historical and critical methods, asserting that these approaches are insufficient to grasp the true meaning of the Qur'an as a sacred text.
Analysis of the Effectiveness of E-Books in Increasing Students' Digital Literacy
Authors: Rejeki Tarigan Jenheri , Kembaren Bella Pitaloka Br , Fionasari Richa , Pambudi Nanda , Hartono Rumanti
Published: September 2024

Background. The digital era makes education require more sophisticated literacy skills to keep up with the era. The ability to search, access, manage, present, and communicate with digital objects is an ability in digital literacy. Books as reading materials can now be accessed through digital, called E-books. The existence of E-books will bring new changes in the way students learn. The presence of E-books will provide convenience, affordability, and availability.
Purpose This study aims to measure the effectiveness of using ebooks in improving students' digital literacy. It also analyzes the factors that influence the effectiveness of using E-books. The presence of E-books as literacy media will be analyzed how influential it is on students' ability to search, access, manage, present and communicate using digital information.
Method. The method used in this research is quantitative. The data obtained is the number of responses. The data obtained was taken from the distribution of questionnaires containing questions and statements regarding the effectiveness of E-books in improving students' digital literacy. The statements presented in the questionnaire are a form of google formula called google from. The data will be processed through SPSS which was previously inputted into excel.
Results. The results of this study state that the use of E-books as digital reading materials will provide facilities for access, distribution, and consumption of reading materials. The practicality offered will make it easier for educators and students to access it. E-books provide interactive features to enhance the reading experience. In addition, E-books will provide long-distance support in online learning. But of course every advantage has disadvantages or limitations in the use of digital technology.
Conclusion This research can be concluded that E-books as reading materials used by teachers and students must be monitored. Analyzing the use of E-books will be useful for identifying inhibiting factors or supporting factors in the world of education. It is also necessary to analyze the effectiveness of using E-books to improve the quality of student literacy. Teachers, parents and formal institutions including students themselves will play an active role in the successful use of E-books in improving digital literacy.
Analysis of factors that influence student preferences for online learning
Authors: Nurteti Lilis , Pardosi Victor Benny Alexsius , Maq Mumu Muzayyin , Hanim Saidatul , Tampubolon Jonris
Published: September 2024

Background. Online learning is a learning system that is not conducted face-to-face between teachers and students. Preference is a tendency made for one thing compared to another. Therefore, one's view on online learning will also vary. The quality and quantity of learning materials that are in accordance with the curriculum, standards, competencies, and student needs will differentiate students' preferences for online learning.
Purpose This research aims to find out the reasons why students prefer online learning or not, and also to find out the factors that significantly influence the effectiveness of online learning. On the other hand, to analyse the appropriate strategy used in the use of media so that it is suitable for learning and can also be accessed by all individuals.
Method. The method used in this research is quantitative. A method in which data is collected in the form of testable numbers. The data obtained is the number of responses. The data is obtained from the distribution of questionnaires containing questions regarding the analysis of factors affecting students' preferences for online learning. The statement presented in the questionnaire is a form of google form. The data will be processed through the oneway anova test on the SPSS application which was previously imported into excel.
Results. The result of this study states that online learning can be done in schools. Online learning is also a way of learning without face-to-face in sharing information or communicating. Online learning has advantages and disadvantages depending on various factors that influence students' preferences for online learning. In addition, it also provides a strategic overview for teachers and students of the situation and what things will be prepared later.
Conclusion This research can be concluded that the preference or choice of each student is different depending on how he/she views the subject. Online learning can be run effectively with good cooperation. Online learning will be implemented if there is support from all parties, be it students, teachers, parents, and even schools. Adjustment in learning is also easier for female students than male students.
Evaluation of the Effect of Using Educational Games on Early Childhood Learning Achievement
Authors: Nurteti Lilis , Srisudarso Mansyur , Wahyuni Annisa , Ramadhan Mariatul Kamila , Ananta Maulana Paramaditya
Published: September 2024

Background. Early childhood from 3-5 years old is classified as a digital native generation. This is triggered by the dependence of individuals on technology. The ease of access in the form of videos and other entertainment will trigger children to do activities. This aspect will help in providing stimulation for children while parents are busy with work. The use of educational games is one form of the role of technology use on the motor and cognitive development of children.
Purpose This study aims to investigate how influential the use of educational games is. Looking for shortcomings and advantages in the use of educational games to be evaluated. Educational games that present interesting animations and images will captivate children when they see them. This will make children enthusiastic and easy to remember things.
Method. The method used in this research is a qualitative method. This method is a way of research that uses numbers. The data collected comes from a questionnaire distributed to teachers at an early age level. The statements presented are loaded on Google from to facilitate access from teachers without taking time. The statements presented are related to evaluating the effect of using educational games on early childhood achievement. The collected data will later be transferred to Excel. After that the data will be inputted into spss to do the oneway anova test.
Results. The result of this research is the use of technology in the form of educational games will help optimize the development and growth of early childhood. However, not all educational games are able to accommodate balanced and comprehensive development. It takes the role of parents and teachers to control the use of technology in early childhood so as not to get addicted.  
Conclusion This research can be concluded that the use of technology in the form of content, educational games and other things in proportion will help improve the learning achievement of children. Proper use according to portions will help without replacing the role of parents and teachers.
The Impact of Implementing Hybrid Learning on Flexibility and Quality of Learning
Authors: Rijal Syamsu , Wei Zhang , Jiao Deng , Wang Yuanyuan
Published: September 2024

Background:The implementation of hybrid learning is a learning method that refers to a learning method that combines or combines face-to-face and online-based learning. By implementing hybrid learning, it is possible for students who have limited infrastructure to study without coming to school.
Research purposes:This research was conducted with the aim of determining the flexibility and quality of learning by implementing hybrid learning. Apart from that, it is also possible to find out about the learning experiences that have been produced through the hybrid learning process.
Method:The method used in this research is a quantitative method.This method is a way of collecting numerical data that can be tested. Data was collected through distributing questionnaires addressed to students. Furthermore, the data that has been collected from the results of distributing the questionnaire will be accessible in Excel format which can then be processed using SPSS.
Results:From the research results, it can be stated that the impact of implementing hybrid learning can help optimize the use of technology in education, so that learning materials can be developed that are more flexible and high quality, and teachers can choose appropriate teaching methods that suit student needs.
Conclusion:From this research, it can be concluded that the impact of implementing hybrid learning can make it easier to carry out the learning process. Where the learning process is not only carried out face to face, but can be carried out online by utilizing existing technology
Efektivitas Penegakan Hukum Terhadap Pelaku Ilegal Logging Oleh Kepolisian Negara Republik Indonesia Daerah Sulawesi Selatan
Authors: Utama Ricky Resky , Pawennei Mulyati , Sutiawati Sutiawati
Published: September 2024

Penelitian ini bertujuan untuk menganalisa serta mengkaji efektivitas penegakan hukum terhadap pelaku illegal logging di Diskreskrimsus Polda Sulsel, dan faktor yang menghambat penegakan hukum terhadap pelaku illegal logging di Diskreskrimsus Polda Sulsel. Penelitian ini menggunakan metode penelitian hukum empiris, yaitu mengumpulkan data penelitian serta mengkaji ketentuan hukum yang berlaku dalam kenyataan di masyarakat. Hasil penelitian ini menunjukkan bahwa : Efektivitas penegakan hukum terhadap pelaku illegal logging di Diskreskrimsus Polda Sulsel, kurang berjalan secara efektif dikarenakan Penyidik Ditreskrimsus Polda Sulsel perlu keterangan dari saksi ahli guna mendukung unsur-unsur tindak pidana illegal logging dalam Berita Acara Pemeriksaan. Faktor yang menghambat penegakan hukum terhadap pelaku illegal logging di Diskreskrimsus Polda Sulsel, yaitu: Keadaan Geografis; Keterbatasan Penyidik Ditreskrimsus Polda Sulsel; Masyarakat. Pada ketiga faktor tersebut yang paling berpengaruh terhadap penegakan hukum terhadap pelaku illegal logging adalah Keterbatasan Penyidik Ditreskrimsus Polda Sulsel.
INSULIN MODULATES MITOCHONDRIAL STRUCTURAL AND FUNCTIONAL MOSAICISM IN BROWN ADIPOCYTES
Authors: Golic Igor , Aleksic Marija , Stojanovic Sara , Zakic Tamara , Jankovic Aleksandra , Korac Bato , Cvoro Aleksandra , Korac Aleksandra
Published: September 2024

Since the discovery of the thermogenic role of brown adipocytes, there was consensus that the biochemical and metabolic function of their mitochondria is uniform. By switching the ATP production between glycolytic pathway and oxidative phosphorylation, brown adipocytes are able to produce heat in mitochondria through uncoupling protein 1 (UCP1). Thermogenically active brown adipocyte mitochondria are characterized by clear morphological features (long, tightly packed cristae). The process of their biogenesis includes an increased number of mitochondria (by division), increase of their surface area, and incorporation of UCP1 as well as specific structural organization of the cristae. But, is it true that all BA mitochondria within one cell are structurally and functionally the same? Do they harbor the same set of enzymes? Actually, the very first cell mosaicism, e.g. Harlequin appearance was shown in brown adipose tissue. This unique uneven UCP1 expression suggests that brown adipocyte’s mitochondria may be heterogeneous regarding production of ATP (bioenergetic) vs. heat (thermogenic) role. This presentation deals with structural and functional mitochondrial mosaicism and changes caused by insulin.

This research was supported by the Science Fund of the Republic of Serbia, #7750238, Exploring new avenues in breast cancer research: Redox and metabolic reprogramming of cancer and associated adipose tissue - REFRAME.
MITOCHONDRIAL DISEASE: FROM MECHANISMS TO THERAPY
Authors: Balmaceda Valeria , Cerutti Raffaele , L. Moore Anthony , Fernandez-Vizarra Erika , Viscomi Carlo
Published: September 2024

Mitochondrial diseases are a large family of extremely heterogeneous disorders genetically determined by mutations in either the nuclear genome or the mitochondrial DNA. Most of the mitochondrial disease genes are expressed in all cell types. However, in many conditions, some cell types are more affected than others. However, the reasons for this tissue-specificity remain poorly understood. To investigate the functional basis of the striking tissue-specificity in mitochondrial diseases, we analyzed several bioenergetic parameters, including oxygen consumption rates, Q redox poise, and reactive oxygen species production in mouse brain and liver mitochondria fueled by different substrates. In addition, we determined how these functional parameters are affected by electron transport chain impairment in a tissue-specific manner using pathologically relevant mouse models lacking either Ndufs4 or Ttc19, leading to complex I or III defects, respectively. No cure is currently available for most of the mitochondrial diseases. We previously showed that the coordinated activation of autophagy, lysosomal biogenesis, and mitochondrial biogenesis by rapamycin, ameliorated the myopathic phenotype of a muscle-specific knockout mouse for Cox15 (Cox15sm), encoding an enzyme involved in heme A biosynthesis. However, the role of mitophagy has been poorly investigated. We found that urolithin A, a direct mitophagy inducer, improved motor performance and myopathy in the Cox15sm mice, without increasing the activity of the respiratory chain complexes in a 10 week-treatment. These results indicate that activation of mitophagy can be a suitable treatment to ameliorate mitochondrial myopathies.
PREPARATION FOR OXIDATIVE STRESS: HISTORY, RECENT ADVANCES AND FUTURE DIRECTIONS
Authors: C Moreira Daniel
Published: September 2024

Many animal species are remarkably resilient to the harmful conditions of hypoxia and reoxygenation, a phenomenon widely observed across many species and environmental settings. The ability to survive oxygen deprivation and reintroduction without significant cellular damage is partially attributed to the upregulation of antioxidants, a strategy termed "Preparation for Oxidative Stress" (POS). The concept of POS is that by producing more antioxidants under hypoxia animals would anticipate the eventual and potentially damaging reintroduction of oxygen. Historically, the specific mechanisms through which POS is activated remained elusive. Over the past decade, significant advancements have been made in understanding POS at a molecular level and in identifying its widespread in the animal kingdom. Notably, a detailed molecular mechanism for the activation of POS under conditions of low oxygen availability has been proposed, emphasizing the role of reactive oxygen species in modulating antioxidant response through redox-sensitive transcription factors. Furthermore, recent research has demonstrated the occurrence of POS in free-ranging animals under completely natural settings, confirming its ecological and physiological relevance. Despite recent advancements, some aspects of POS remain underexplored and should be prioritized in future research. These include the experimental validation of the mechanisms proposed to underlie POS and the assessment of the relevance of POS in multi-stressor scenarios, particularly to understand how organisms cope with combined stressors in fluctuating environments.
ROLE OF MITOCHONDRIA IN THE PHYSIOPATHOLOGY OF THE CARDIOMYOPATHY ASSOCIATED TO FRIEDREICH’S ATAXIA. STUDIES IN HUMAN iPS CELLS
Authors: Lapeña Tamara , Noverques Rita , Romero-Llopis Blanca , Baquero Lorena , Roldán-Lázaro Marta , González-Cabo Pilar , V Pallardó Federico
Published: September 2024

Friedreich's ataxia (FRDA) (OMIM #229300, ORPHA95) is a rare hereditary disease with a prevalence of 1/20,000 to 1/50,000 in the European population. It is classified as a hereditary peripheral neuropathy of a sensory type, with autosomal recessive inheritance. This disease is caused by the deficiency of a mitochondrial protein called frataxin. Lack of expression of this protein produces accumulation of iron, alterations in the biogenesis of iron-sulfur clusters, failures in complexes I, II and III of the respiratory chain and in the activity of the aconitase enzyme, and a reduction in the biosynthesis of the heme groups. As a consequence, finally, an overload of ROS derived from the Fenton reaction occurs. Together with the movement impairment, 60% of FRDA patients suffer cardiomyopathy, which is the most common cause of death in these patients and has no clear explanation of its physiopathological cause. Two iPSC cell lines from FRDA patients with cardiomyopathy) and a control line were differentiated to ventricular cardiomyocytes in our lab.  Both FRDA cell lines showed changes in heartbeat parameters, such as heart rate and amplitude when compared to the control cell line. Also, calcium homeostasis measured by immunofluorescence showed important differences when compared to the control cell line. RT-PCR analyses of miRNAs related to myocardial function also showed clear differences, especially for miR-323-3p and miR-142-3p. Using EM, we found differences in the mitochondrial size, shape and in mitochondrial cristae organization. These results also correlate with changes in the cardiomyocytes cytoskeleton and in the structure of the sarcomeres using confocal microscopy techniques. Our results showed the correlation between mitochondrial changes and the impairment in ventricular cardiomyocytes activity derived from FRDA’s iPS cells.
OXYSTEROLS: FROM MOLECULAR BIOLOGY TO MEDICINE AND INDUSTRY
Authors: Poli Giuseppe
Published: September 2024

Oxysterols are oxidized derivatives of cholesterol initially considered as simple metabolic byproducts, nowadays recognized to play significant roles in various biological and pathological processes. In physiology, they are involved in the regulation of cellular processes beyond cholesterol metabolism, influencing cell proliferation, differentiation, apoptosis, and inflammation through various signaling pathways. In medicine, the study of oxysterols holds promise for understanding and treating various diseases, particularly those associated with dysregulated cholesterol metabolism and inflammation. Indeed, some oxysterols have been associated with adverse health effects, including cytotoxicity, pro-inflammatory effects, and potential contributions to the development of chronic diseases. Dysfunctions in oxysterol metabolism have been implicated in the pathogenesis of cardiovascular diseases, neurodegenerative disorders, and certain cancers. Targeting oxysterol pathways could therefore offer novel therapeutic strategies for these conditions. Oxysterols have potential applications in the pharmaceutical and biotechnology industries. Those generated by cholesterol autoxidation can be used as biomarkers for assessing oxidative stress conditions. Additionally, defined oxysterols of enzymatic origin and/or synthetic oxysterol analogs might be developed as antiviral agents. Oxysterols generated through autoxidation processes can serve as markers of lipid oxidation in cholesterol-containing foods and their quantification can help assess the quality and shelf life of food products, and also for ensuring food safety and consumer health. Finally, with regard to skin health and cosmetics industry, prolonged or excessive exposure to and/or formation of certain toxic oxysterols could potentially damage skin cells and disrupt skin barrier function. Therefore, careful formulation and dosage control are essential to ensure the safety of skincare products. Overall, the study of oxysterols spans molecular biology, medicine, and industry, with implications for understanding fundamental biological processes, developing new medical, industrial, and advancing biotechnological applications.
REGULATION OF INTRACELLULAR CYSTINE REDUCTION AND PROTEIN CYSTEINYLATION
Authors: Sastre Juan
Published: September 2024

The reduction of intracellular cystine to yield cysteine is critical for protein or glutathione synthesis and many other important biological processes, but its regulation is still unknown. We have shown that the thioredoxin-related protein of 14 kDa (TRP14) is the rate-limiting enzyme for intracellular cystine reduction. Upon TRP14 deficiency, cysteine synthesis through the transsulfuration pathway becomes the major source of cysteine in human cells, and knockout of both pathways is lethal in C. elegans subjected to proteotoxic stress. TRP14 can also reduce protein cysteinylation. However, paradoxically TRP14 knock-out mice were protected in acute pancreatitis through activation of Nrf2 and upregulation of the transsulfuration pathway, thus exhibiting less inflammatory infiltrate and edema. Therefore, TRP14 seems to be the enzyme principally responsible for intracellular cystine reduction, and it is also able to regulate protein cysteinylation together with thioredoxin 1.
Hibernation and Neuroprotection: Differential Expression of Ferroptosis-Related Genes in Arctic Ground Squirrels
Authors: Drew Kelly L , Hood Elizabeth , Yoldi  Bergua Iñigo , B Fedorov Vadim , Goropashnaya Anna V
Published: September 2024

Ferroptosis, a form of regulated cell death characterized by iron-dependent lipid peroxidation, is linked to neurodegenerative disorders and cold-induced cell death. SLC7A11 (xCT) plays a crucial role in protecting cells against ferroptosis by maintaining intracellular cysteine and glutathione levels. SLC7A11 requires the chaperone protein SLC3A2 for its localization on the plasma membrane to mediate cystine uptake. Arctic ground squirrels (AGS) are known to be protected from cold tissue temperatures and oxidative stress and to resist neuropathology following cerebral ischemia/reperfusion. This study investigated how ferroptosis is influenced by the hibernation season in AGS hippocampus. RNA-Seq, gene expression, and differential gene expression analysis were conducted on hippocampus tissue samples from male and female AGS collected during the summer active season, torpor, and interbout arousal (IBA). Hippocampus was dissected from partially thawed whole brain prior to RNA extraction.  Total RNA samples were used for cDNA library construction and sequencing by BGI Americas Corporation (Cambridge, MA) and analyzed using CLC Genomics Workbench (QIAGEN). Genes were mapped to the Ictidomys tridecemlineatus reference genome and transcript (HiC_Itri_2, GCF_016881025.1). Results show the highest number of differentially expressed genes (4,042) in torpor compared to summer active animals. Notably, SLC7A11 expression was elevated in torpor compared to summer active animals (fold change: 1.80, FDR-p value: 0.0034). Additionally, SLC3A2 was significantly upregulated in torpor compared to IBA (fold change: 1.24; FDR-p value: 0.030). SLC7A11 transports glutamate(out)/cystine(in). Cystine is rapidly converted into cysteine, a limiting reactant for glutathione synthesis, in the presence of NADPH. These findings suggest that SLC7A11 and SLC3A2 may protect AGS from ferroptosis during the hibernation season. This research provides insights into the molecular mechanisms underlying neuroprotection in hibernating AGS and may have implications for understanding and potentially treating neurodegenerative disorders.