bluuebunny/crossref_metadata_2025 huggingface dataset:
Distinct Propagation to Agricultural Drought Between Two Severe Meteorological Droughts in the Korean Peninsula
Authors: Ham Yoo‐Geun , Jeong Yerim , Seo Eunkyo
Published: November 2024

Distinct responses in the soil moisture (SM) between the two most severe meteorological droughts in Korea are examined. Although total accumulated precipitation deficit during 1994–1996 drought was slightly less than in the 2013–2017 drought, 1994–1996 drought showed a record‐breaking negative SM anomalies, while the accumulated negative SM anomalies during 2013–2017 were less than half of those in 1994–1996. In 1994–1996 case, robust precipitation deficits occurred early in the event, leading to subsequent precipitation shortages under dry conditions. In addition, precipitation deficit was observed not only during wet seasons but also throughout dry seasons. This amplifies the SM response, as the runoff volume remains relatively constant despite reduced precipitation in arid soil conditions, which eventually reduces soil water retention led by the precipitation deficit. Conversely, in 2013–2017 case, precipitation deficit occurred during later period of the event and wet seasons, which leads a moderate SM drying signals.
Factors Affecting the Weakening Rate of Landfalling Tropical Cyclones Over China
Authors: Liu Lu , Liang Zhaoming , Wang Yuqing
Published: November 2024

Based on the 6‐hourly tropical cyclone best track and global reanalysis data, statistical analyses and a machine learning approach are used to identify/quantify factors that affect the relative weakening rate (RWR) of landfalling TCs (LTCs) over China mainland during 1980–2020. Results show that the enhanced RWR of LTC events usually occurs when LTCs move into regions with large environmental vertical wind shear (VWS), large surface roughness (SURR), high land surface soil temperature (SOILT), low surface latent heat flux (SLHF), and with relatively faster translational speeds (SPD). The SPD and SURR are dominant factors determining the RWR of LTCs over China mainland, contributing about 20% and 18.5% to the RWR of LTCs. VWS is also a key factor affecting RWR of LTCs with mid‐level VWS contributing 17.8% to RWR of LTCs and low‐ and deep‐level VWS contributing about 12.9% and 11.2%, respectively. Furthermore, factors affecting the LTC weakening rate in south and north China are different. In north China, the VWS at different levels are all highly correlated with LTC RWR after landfall, whereas the influence of mid‐layer VWS shows significant correlation with LTC RWR in south China. In addition, surface characteristics, including SURR, SLHF, and SOILT, have significant correlation with LTC RWR in south China. But the relationships between surface characteristics and LTC RWR in north China are not statistically significant. It is worth noting that although the correlation between DIV200 and LTC RWR is insignificant for the whole China mainland, it presents highly negative and positive correlations in south and north China, respectively.
p63 affects distinct metabolic pathways during keratinocyte senescence, evaluated by metabolomic profile and gene expression analysis
Authors: Piro Maria Cristina , Pecorari Rosalba , Smirnov Artem , Cappello Angela , Foffi Erica , Lena Anna Maria , Shi Yufang , Melino Gerry , Candi Eleonora
Published: November 2024

Unraveling the molecular nature of skin aging and keratinocyte senescence represents a challenging research project in epithelial biology. In this regard, depletion of p63, a p53 family transcription factor prominently expressed in human and mouse epidermis, accelerates both aging and the onset of senescence markers in vivo animal models as well as in ex vivo keratinocytes. Nonetheless, the biochemical link between p63 action and senescence phenotype remains largely unexplored. In the present study, through ultrahigh performance liquid chromatography–tandem mass spectroscopy (UPLC–MS/MS) and gas chromatography/mass spectrometry (GC/MS) metabolomic analysis, we uncover interesting pathways linking replicative senescence to metabolic alterations during p63 silencing in human keratinocytes. Integration of our metabolomic profiling data with targeted transcriptomic investigation empowered us to demonstrate that absence of p63 and senescence share similar modulation profiles of oxidative stress markers, pentose phosphate pathway metabolites and lyso-glycerophospholipids, the latter due to enhanced phospholipases gene expression profile often under p63 direct/indirect gene control. Additional biochemical features identified in deranged keratinocytes include a relevant increase in lipids production, glucose and pyruvate levels as confirmed by upregulation of gene expression of key lipid synthesis and glycolytic enzymes, which, together with improved vitamins uptake, characterize senescence phenotype. Silencing of p63 in keratinocytes instead, translates into a blunted flux of metabolites through both glycolysis and the Krebs cycle, likely due to a p63-dependent reduction of hexokinase 2 and citrate synthase gene expression. Our findings highlight the potential role of p63 in counteracting keratinocyte senescence also through fine regulation of metabolite levels and relevant biochemical pathways. We believe that our research might contribute significantly to the discovery of new implications of p63 in keratinocyte senescence and related diseases.
Ally or traitor: the dual role of p62 in caspase-2 regulation
Authors: Volik Pavel I. , Zamaraev Alexey V. , Egorshina Aleksandra Y. , Pervushin Nikolay V. , Kapusta Anastasia A. , Tyurin-Kuzmin Pyotr A. , Lipatova Anastasia V. , Kaehne Thilo , Lavrik Inna N. , Zhivotovsky Boris , Kopeina Gelina S.
Published: November 2024

Caspase-2 is a unique and conserved cysteine protease that is involved in several cellular processes, including different forms of cell death, maintenance of genomic stability, and the response to reactive oxygen species. Despite advances in caspase-2 research in recent years, the mechanisms underlying its activation remain largely unclear. Although caspase-2 is activated in the PIDDosome complex, its processing could occur even in the absence of PIDD1 and/or RAIDD, suggesting the existence of an alternative platform for caspase-2 activation. Here, we show that caspase-2 undergoes ubiquitination and interacts with scaffolding protein p62/sequestosome-1 (SQSTM1) under normal conditions and in response to DNA damage. p62 promotes proteasomal but not autophagic caspase-2 degradation as well as its dimerization and activation that triggers the caspase cascade and, subsequently, cell death. Inhibition of p62 expression attenuates cisplatin-induced caspase-2 processing and apoptosis. Notably, the ZZ domain of p62 is critical for caspase-2 binding, whereas the UBA domain is seemingly required to stabilize the p62–caspase-2 complex. Thus, we have uncovered the dual role of p62 in regulating caspase-2 activity: it can foster the degradation of caspase-2 in the proteasome or facilitate its activation by acting as a scaffold platform.
Glial maturation factor-β deficiency prevents oestrogen deficiency-induced bone loss by remodelling the actin network to suppress adipogenesis of bone marrow mesenchymal stem cells
Authors: Xu Jun , Huang Zhongyue , Shi Si , Xia Jiangni , Chen Guangnan , Zhou Kaifeng , Zhang Yiming , Bian Chong , Shen Yuqin , Yin Xiaofan , Lu Lixia , Gu Huijie
Published: November 2024

An imbalance between the adipogenesis and osteogenesis of bone marrow mesenchymal stem cells (BMSCs) is considered the basic pathogenesis of osteoporosis. Although actin cytoskeleton remodelling plays a crucial role in the differentiation of BMSCs, the role of actin cytoskeleton remodelling in the adipogenesis of BMSCs and postmenopausal osteoporosis (PMOP) has remained elusive. Glia maturation factor-beta (GMFB) has a unique role in remodelling the polymerization/depolymerization cycles of actin. We observed that GMFB expression was increased in bone tissue from both ovariectomized (OVX) rats and PMOP patients. GMFB knockout inhibited the accumulation of bone marrow adipocytes and increased bone mass in the OVX rat model. The inhibition of adipocyte differentiation in GMFB knockout BMSCs was mediated via actin cytoskeleton remodelling and the Ca2+-calcineurin-NFATc2 axis. Furthermore, we found that GMFB shRNA treatment in vivo had favourable effects on osteoporosis induced by OVX. Together, these findings suggest a pathological association of the GMFB with PMOP and highlight the potential of the GMFB as a therapeutic target for osteoporosis patients.
Genetic basis of right and left ventricular heart shape
Authors: Burns Richard , Young William J. , Aung Nay , Lopes Luis R. , Elliott Perry M. , Syrris Petros , Barriales-Villa Roberto , Sohrabi Catrin , Petersen Steffen E. , Ramírez Julia , Young Alistair , Munroe Patricia B.
Published: November 2024

Heart shape captures variation in cardiac structure beyond traditional phenotypes of mass and volume. Although observational studies have demonstrated associations with cardiometabolic risk factors and diseases, its genetic basis is less understood. We utilised cardiovascular magnetic resonance images from 45,683 UK Biobank participants to construct a heart shape atlas from bi-ventricular end-diastolic surface mesh models through principal component (PC) analysis. Genome-wide association studies were performed on the first 11 PCs that captured 83.6% of shape variance. We identified 43 significant loci, 14 were previously unreported for cardiac traits. Genetically predicted PCs were associated with cardiometabolic diseases. In particular two PCs (2 and 3) linked with more spherical ventricles being associated with increased risk of atrial fibrillation. Our study explores the genetic basis of multidimensional bi-ventricular heart shape using PCA, reporting new loci and biology, as well as polygenic risk scores for exploring genetic relationships of heart shape with cardiometabolic diseases.
Reintroduction of resistant frogs facilitates landscape-scale recovery in the presence of a lethal fungal disease
Authors: Knapp Roland A. , Wilber Mark Q. , Joseph Maxwell B. , Smith Thomas C. , Grasso Robert L.
Published: November 2024

Vast alteration of the biosphere by humans is causing a sixth mass extinction, driven in part by an increase in infectious diseases. The emergence of the lethal fungal pathogen Batrachochytrium dendrobatidis (Bd) has devastated global amphibian biodiversity. Given the lack of any broadly applicable methods to reverse these impacts, the future of many amphibians appears grim. The Sierra Nevada yellow-legged frog (Rana sierrae) is highly susceptible to Bd infection and most R. sierrae populations are extirpated following disease outbreaks. However, some populations persist and eventually recover, and frogs in these recovering populations have increased resistance against infection. Here, we conduct a 15-year reintroduction study and show that frogs collected from recovering populations and reintroduced to vacant habitats can reestablish populations despite the presence of Bd. In addition, the likelihood of establishment is influenced by site, cohort, and frog attributes. Results from viability modeling suggest that many reintroduced populations have a low probability of extinction over 50 years. These results provide a rare example of how reintroduction of resistant individuals can allow the landscape-scale recovery of disease-impacted species, and have broad implications for amphibians and other taxa that are threatened with extinction by novel pathogens.
DHX36 binding induces RNA structurome remodeling and regulates RNA abundance via m6A reader YTHDF1
Authors: Zhang Yuwei , Zhao Jieyu , Chen Xiaona , Qiao Yulong , Kang Jinjin , Guo Xiaofan , Yang Feng , Lyu Kaixin , Ding Yiliang , Zhao Yu , Sun Hao , Kwok Chun-Kit , Wang Huating
Published: November 2024

RNA structure constitutes a new layer of gene regulatory mechanisms. RNA binding proteins can modulate RNA secondary structures, thus participating in post-transcriptional regulation. The DEAH-box helicase 36 (DHX36) is known to bind and unwind RNA G-quadruplex (rG4) structure but the transcriptome-wide RNA structure remodeling induced by DHX36 binding and the impact on RNA fate remain poorly understood. Here, we investigate the RNA structurome alteration induced by DHX36 depletion. Our findings reveal that DHX36 binding induces structural remodeling not only at the localized binding sites but also on the entire mRNA transcript most pronounced in 3’UTR regions. DHX36 binding increases structural accessibility at 3’UTRs which is correlated with decreased post-transcriptional mRNA abundance. Further analyses and experiments uncover that DHX36 binding sites are enriched for N6-methyladenosine (m6A) modification and YTHDF1 binding; and DHX36 induced structural changes may facilitate YTHDF1 binding to m6A sites leading to RNA degradation. Altogether, our findings uncover the structural remodeling effect of DHX36 binding and its impact on RNA abundance through regulating m6A dependent YTHDF1 binding.
Face cells encode object parts more than facial configuration of illusory faces
Authors: Sharma Saloni , Vinken Kasper , Jagadeesh Akshay V. , Livingstone Margaret S.
Published: November 2024

Humans perceive illusory faces in everyday objects with a face-like configuration, an illusion known as face pareidolia. Face-selective regions in humans and monkeys, believed to underlie face perception, have been shown to respond to face pareidolia images. Here, we investigated whether pareidolia selectivity in macaque inferotemporal cortex is explained by the face-like configuration that drives the human perception of illusory faces. We found that face cells responded selectively to pareidolia images. This selectivity did not correlate with human faceness ratings and did not require the face-like configuration. Instead, it was driven primarily by the “eye” parts of the illusory face, which are simply object parts when viewed in isolation. In contrast, human perceptual pareidolia relied primarily on the global configuration and could not be explained by “eye” parts. Our results indicate that face-cells encode local, generic features of illusory faces, in misalignment with human visual perception, which requires holistic information.
Predicting rainfall using machine learning, deep learning, and time series models across an altitudinal gradient in the North-Western Himalayas
Authors: Wani Owais Ali , Mahdi Syed Sheraz , Yeasin Md. , Kumar Shamal Shasang , Gagnon Alexandre S. , Danish Faizan , Al-Ansari Nadhir , El‑Hendawy Salah , Mattar Mohamed A.
Published: November 2024

Predicting rainfall is a challenging and critical task due to its significant impact on society. Timely and accurate predictions are essential for minimizing human and financial losses. The dependence of approximately 60% of agricultural land in India on monsoon rainfall implies the crucial nature of accurate rainfall prediction. Precise rainfall forecasts can facilitate early preparedness for disasters associated with heavy rains, enabling the public and government to take necessary precautions. In the North-Western Himalayas, where meteorological data are limited, the need for improved accuracy in traditional modeling methods for rainfall forecasting is pressing. To address this, our study proposes the application of advanced machine learning (ML) algorithms, including random forest (RF), support vector regression (SVR), artificial neural network (ANN), and k-nearest neighbour (KNN) along with various deep learning (DL) algorithms such as long short-term memory (LSTM), bi-directional LSTM, deep LSTM, gated recurrent unit (GRU), and simple recurrent neural network (RNN). These advanced techniques hold the potential to significantly improve the accuracy of rainfall prediction, offering hope for more reliable forecasts. Additionally, time series techniques, including autoregressive integrated moving average (ARIMA) and trigonometric, Box-Cox transform, arma errors, trend, and seasonal components (TBATS), are proposed for predicting rainfall across the altitudinal gradients of India’s North-Western Himalayas. This approach can potentially revolutionise how we approach rainfall forecasting, ushering in a new era of accuracy and reliability. The effectiveness and accuracy of the proposed algorithms were assessed using meteorological data obtained from six weather stations at different elevations spanning from 1980 to 2021. The results indicate that DL methods exhibit the highest accuracy in predicting rainfall, as measured by the root mean squared error (RMSE) and mean absolute error (MAE), followed by ML algorithms and time series techniques. Among the DL algorithms, the accuracy order was bi-directional LSTM, LSTM, RNN, deep LSTM, and GRU. For the ML algorithms, the accuracy order was ANN, KNN, SVR, and RF. These findings suggest that altitude significantly affects the accuracy of the models, highlighting the need for additional weather stations in this mountainous region to enhance the precision of rainfall prediction.
Image processing and artificial neural network based determination of surface mean texture depth on lab-controlled chip seal pavement samples
Authors: GÖKALP İslam , UZ Volkan Emre , BARSTUĞAN Mücahid , BALCI Mehmet Can
Published: November 2024

Because surface texture is nearly the sole indicator of pavement functional properties and highly correlated with critical operational characteristics of roadways like traffic noise and safety, the change in pavement surface texture because of traffic loadings and environment has to be evaluated routinely. There are numerous direct or indirect evaluation techniques in the market. However, most of these methods have some limitations like requiring lane closure or being expensive. In this study, a 2D image processing method was established to estimate the surface mean texture depth (MTD) of chip sealed pavements. We produced chip sealed pavement samples in the laboratory with different aggregate type, shape, and size ranging between 2 and 19 mm to cover wide range of live conditions. Two well-known conventional test methods, Sand Patch (SP) and Hydrotimer (HT), were used to determine MTDs of chip seal samples. Subsequently numerous photos were taken on surface of the samples with a camera for 2-D image processing that was done based on surface void ratio (SVR) approach. With the image processing, SVR of all samples were determined. At the point of whether there is a relationship or not, correlation analysis was made between the MTDs obtained with SP and HT and the data obtained by SVR approach with the artificial neural network method. The results show that the proposed SVR approach construed on 2D image processing method can be a reliable alternative to evaluate the surface texture of pavements.
Investigating the effects of make-up water dilution and oil presence on polymer retention in carbonate reservoirs
Authors: Sebastian Anoo , Mushtaq Muhammad , Al-Shalabi Emad Walid , AlAmeri Waleed , Mohanty Kishore , Masalmeh Shehadeh , AlSumaiti Ali M.
Published: November 2024

The application of polymer flooding is challenging in harsh temperature and salinity conditions in Middle-Eastern carbonate reservoirs, as they can deteriorate the commonly used polymers such as Hydrolyzed Polyacrylamide (HPAM). One solution to this issue is the use of newly developed Acrylamido-Tertiary-Butyl Sulfonate (ATBS) based polymers, which can endure adverse temperature and salinity conditions. However, they also tend to adsorb onto carbonate rocks with positive surface charge. This study aims to tackle the problem of high polymer retention by employing low-salinity polymer flooding. For that coreflooding experiments were conducted on an ATBS-based polymer in salinities ranging from 400 to 167,000 ppm using fully water-saturated cores and cores at residual oil saturation (Sor). The single-phase retention experiments determined polymer retention values of around 25 µg/g-rock when using diluted brines, which is about half of the retention values (47–56 µg/g-rock) observed with high salinity seawater (43,000 ppm) and formation water (167,000 ppm). Furthermore, the retention of the ATBS-based polymer was further reduced by 50% in the presence of oil compared to the experiments conducted in the absence of oil. The results demonstrated that an optimal salinity threshold of 10,000 ppm and lower yields significant improvements in the efficiency of polymer flooding.
Recent advances and future prospects in oxidative-reduction low-triggering-potential electrochemiluminescence strategies based on nanoparticle luminophores
Authors: Fu Li , Song Tianyuan , Li Qi , Zou Guizheng , Zhang Fuwei , Li Zongchao , Guan Haotian , Guo Yingshu
Published: November 2024

Schematic diagram of the strategies used for LTP ECL.
A simple and highly sensitive colorimetric assay for the visual detection of lead and chromium using ascorbic acid capped gold nanoparticles
Authors: Hladun Colby , Beyer Maximilian , Paliakkara John , Othman Ali , Bou-Abdallah Fadi
Published: November 2024

Illustration of metal ions (Mn+) detection using ascorbic acid-capped gold nanoparticles, with a visual color change observed by the naked eye at ∼20 ppb for Pb2+ and ∼30–40 ppb for Cr3+/6+ cations.
Engineering highly efficient porphyrin sensitizers through metal, ligand and bridge modification: a DFT study
Authors: Kaur Hemjot , Goel Neetu
Published: November 2024

Tailoring porphyrin molecules for optimal solar cell performance: achieving record-breaking efficiency.
Study on the optical mechanism of photorefractive resistance in Zr-doped lithium niobate crystals from first-principle calculations
Authors: Wang Weiwei , Liu Hongde , Zheng Dahuai , Liu Yue , Kong Yongfa , Xu Jingjun
Published: November 2024

The birefringence of pure LN and LN with different Zr defect clusters calculated at the wavelength λ = 1064 nm.
An eco-friendly electrochemical approach for determination of sunset yellow at a Co3O4@biochar modified pencil graphite electrode
Authors: Tong Wenting , Ma Zhichao , Zhang Shulin , Jiang Apei , Wei Ming , Jia Jianhua , Lu Wenbo
Published: November 2024

A simple, low-cost, and sustainable pencil graphite electrode modified with Co3O4@biochar is proposed for the accurate detection of sunset yellow in beverages.
A flexible and energy independent fluorescence radiation fiber film dosimeter fabricated by electrostatic spinning
Authors: Tang Mingshuo , He Zhiwei , Wang Zhihao , Wang Yunlong
Published: November 2024

This article proposes a flexible and energy independent fluorescence radiation fiber film dosimeter fabricated by electrostatic spinning, providing a candidate material for wearable visual dosimeters for X-ray detection in the range of 0–350 Gy.
Effect of architecture on the thermo-induced phase transition of methacrylate-based symmetric pentablock terpolymers
Authors: Wang Shaobai , Liu Xu , Wang Shuchen , Georgiou Theoni K.
Published: November 2024

A series of six symmetric pentablock terpolymers were synthesised using group transfer polymerisation (GTP).
Nanostructured MnOx/g-C3N4 for photodegradation of sulfamethoxazole under visible light irradiation
Authors: Nguyen Oanh T. K. , Nguyen Vinh Huu , Linh Nong Xuan , Doan Minh Que , Hoang Lan-Anh T. , Lee Taeyoon , Nguyen Trinh Duy
Published: November 2024

The MnOx/g-C3N4 heterojunction photocatalyst, with enhanced charge separation and redox capabilities, achieved 85% sulfamethoxazole degradation, exhibiting high reusability with minimal ecological risk.
A new herbal extract carbon nanodot nanomedicine for anti-renal cell carcinoma through the PI3K/AKT signaling pathway
Authors: Tian Ning , Liu Xiangling , He Xiaoyu , Liu Ying , Xiao Lizhi , Wang Penghui , Zhang Di , Zhang Zhe , Zhao Yu , Lin Quan , Fu Changkui , Jiang Yingnan
Published: November 2024

New Re carbon nanodots with narrow size distribution, good water solubility and high cell membrane permeability were prepared from a herbal extract.
Hyperconjugation-controlled molecular conformation weakens lithium-ion solvation and stabilizes lithium metal anodes
Authors: Chen Yuelang , Liao Sheng-Lun , Gong Huaxin , Zhang Zewen , Huang Zhuojun , Kim Sang Cheol , Zhang Elizabeth , Lyu Hao , Yu Weilai , Lin Yangju , Sayavong Philaphon , Cui Yi , Qin Jian , Bao Zhenan
Published: November 2024

The hyperconjugation-controlled molecular conformation can tune the solvation properties of electrolytes, providing a new design principle for battery electrolyte engineering.
A tetrathiafulvalene-containing covalent organic nanobelt: preparation, crystal structure and application for sodium-ion batteries
Authors: Wang Xin , Zhang Yuchan , Zhang Lei , Gu Qianfeng , Liu Qi , Ren Yang , Lee Chun Sin , Zhang Qichun
Published: November 2024

Single crystals of covalent organic polymers (CityU-26) with a nanobelt structure were obtained via B–N-driven assembly, demonstrating an impressive sodium storage capability of 365 mA h g−1 at 150 mA g−1.
Catechin-induced cellulose: a new material for harvesting triboelectricity
Authors: Hisna P. A. , Pradyumnan P. P.
Published: November 2024

The desire to meet energy demands drives us to develop environment-friendly, renewable, and sustainable energy sources.
Development of optimal real‐time metro operation strategy minimizing total passenger travel time and train energy consumption
Authors: Oh Yoonseok , Kwak Ho‐Chan , Kang Seungmo
Published: November 2024

The optimization of the total passenger travel time and total train energy consumption are critical factors in metro operation optimization. However, deriving an optimal train operation plan that incorporates both passenger travel time and total train energy consumption is a complex task because it should consider numerous variables representing the operational status of the urban railway, such as the number of boarding and alighting passengers, number of on‐board passengers in each train, and entire train operation status along the line. Moreover, owing to the fluctuating nature of passenger demand, which can change rapidly over time, its optimization becomes challenging. To address this challenge, this study develops a recurrent neural network‐based real‐time metro operation optimization model trained using data representing the moments when the trains departed from the stations. These data are derived and reconstructed from various simulated operation plans while searching for optimal daily metro timetable. Consequently, the proposed model derives the real‐time optimal operation strategies for trains departing from the next station within an average of 0.18 s. The result of metro operation simulations using proposed optimal operation strategies reveals a 7–14% improvement in efficiency compared to the current train operation strategies.
Optimal capacity configuration of joint system considering uncertainty of wind and photovoltaic power and demand response
Authors: Luo Yuanxiang , Hao Haixin , Fan Lidong
Published: November 2024

To reduce phenomenon of abandoning wind and photovoltaic power, improve the limitations of traditional methods in dealing with uncertainty of wind and photovoltaic power and system planning, and improve the optimal configuration of resources, an optimal capacity configuration of joint system considering uncertainty of wind and photovoltaic power and demand response is proposed. Firstly, using probability distribution information of wind and photovoltaic power output, the distance between actual probability distribution and forecast probability distribution is constrained based on the 1‐norm and ∞‐norm. A fuzzy set considering uncertainty probability distribution is constructed, and a two‐stage distributed robust planning model is established. The first stage involves optimizing joint system capacity for scenarios with the lowest probability of wind and photovoltaic power; the second stage builds on capacity optimization scheme from the first stage and aims to minimize operating costs through simulation optimization. Secondly, column and constraint generation is used to solve the model. Finally, constructing an example based on actual data from a power grid in Northeast China for simulation and analysis, the results show that the method achieves a balanced optimization of robustness and economy, effectively reduces carbon emissions and improves ability of the system to consume wind and photovoltaic power.
siRNAEfficacyDB: An experimentally supported small interfering RNA efficacy database
Authors: Zhang Yang , Yang Ting , Yang Yu , Xu Dongsheng , Hu Yucheng , Zhang Shuo , Luo Nanchao , Ning Lin , Ren Liping
Published: November 2024

Small interfering RNA (siRNA) has revolutionised biomedical research and drug development through precise post‐transcriptional gene silencing technology. Despite its immense potential, siRNA therapy still faces technical challenges, such as delivery efficiency, targeting specificity, and molecular stability. To address these challenges and facilitate siRNA drug development, we have developed siRNAEfficacyDB, a comprehensive database that integrates experimentally validated siRNA efficacy data. This database contains 3544 siRNA records, covering 42 target genes and 5 cell lines. It provides detailed information on siRNA sequences, target genes, inhibition efficiencies, experimental techniques, cell lines, siRNA concentrations, and incubation times. siRNAEfficacyDB offers a user‐friendly web interface that makes it easy to query, browse and analyse data, enabling efficient access to siRNA‐related information. In summary, siRNAEfficacyDB provides a useful data foundation for siRNA drug design and optimisation, serving as a valuable resource for advancing computer‐aided siRNA design research and nucleic acid drug development. siRNAEfficacyDB is freely available at https://cellknowledge.com.cn/siRNAEfficacy for non‐commercial use.
RETRACTED: Changes in microalgae composition under the impact of the scallop Mizuhopecten yessoensis
Authors: Botsun Liudmila , Markina Zhanna , Maslennikov Sergey , Huo Zhongming
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Fish health and parasitic invasions in the Azov sea: Current trends and challenges
Authors: Kazarnikova Anna , Stepanova Yulia , Starikova Tatyana , Balykin Pavel , Startsev Alexander , Savitskaya Svetlana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Substantiation of the processing technology of wheat grains of early ripeness as the feed additive for fish
Authors: Pakhomov Viktor , Braginets Sergey , Bakhchevnikov Oleg , Sharaby Noureldin , Deev Konstantin
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Application of vitamin B12, vitamin E and trace element selenium during the period of preparation of sturgeon producers for spawning
Authors: Ponomareva Elena , Kovalevа Angelika , Shirina Yulia , Grigoriev Vadim , Kuzov Anton , Firsova Angelina
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The effect of different variants of pig introductory crossing on the variability of blood protein metabolism
Authors: Garskaya Natal`ya , Tresnitskiy Sergey , Rudenko Andrey , Kochetkova Anastasiya , Savenkov Alexey
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Machine learning insights into log files with ML.NET for real-time farm monitoring
Authors: Nuriev Marat , Zaripova Rimma , Filimonova Tamara , Kuznetsov Maxim
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Formal representation of the predicate structure based on the neurocognitive architecture
Authors: Boziev Alberd , Makoeva Dana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Methods of scientific foresight in assessing the sustainability of the functioning of enterprises in high-tech industries
Authors: Kazmina Irina , Rodionova Valentina , Krasnikova Anna , Shchegoleva Tatiana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: AI as driver of intellectual transport infrastructure ecosystem: Current issues
Authors: Drozdova Maria , Berezovskaya Irina , Shipunova Olga
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Problems of reconstruction of Shchelkovskoe highway in the Moscow region
Authors: Mezentsev Sergei , Krasheninnikova Evgenija , Norenkov Sergei , Gavrikov Denis
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The choice of dispatching personnel for effective management of transport processes
Authors: Tsoi Ekaterina
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Possibilities of applying the technology and stages of implementing artificial intelligence in the modern economy
Authors: Barsukova N. V. , Morin K. A. , Lozovaya O. V. , Chivileva I. V. , Martynushkin A. B. , Polyakov M. V.
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: User self-protection strategies of digital freedom
Authors: Andreeva Julia , Mihaylova Margarita , Nezhelskaya Irina , Chizhkova Yana
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Institutional factors of labour potential development in the context of financial support for transformation of social infrastructure
Authors: Konorev Aleksandr , Artemov Vladimir , Krivoshlykov Vladimir
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Digital transformation in social sector development and environmental impact on digital economy
Authors: Uktamov Khusniddin , Khanova Nodira , Shadibekova Dildor , Pulatkhodjaeva Dono
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Development of a new approach to ensuring the economic security of Uzbekistan agricultural enterprises
Authors: Uktamov Khusniddin , Abdullayeva Shakhnoza , Imomov Jamshidxon , Rejapov Xayrillo
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Sustainable development and social investment strategies as an element of the SDGS
Authors: Bortnik Artem , Lisin Anton , Niyazbekova Shakizada , Turdiyeva Zukhra , Varzin Vasiliy , Tsurova Lisa , Ugurchiev Omar
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Methods and algorithms for differentiated dietary nutrition during prenatal fetal development
Authors: Abdullayeva Zamira , Shikhnazarova Guzal , Fayzullaeva Zarnigor
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: Resource of copying strategies in the prevention of professional burnout of engineering specialists
Authors: Shcherbakova Tatyana , Stashkova Tatyana , Marinenko Tatyana , Akopyan Marina , Gshiyants Roman , Sargsyan Levon
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
RETRACTED: The impact of swimming classes on restoring psychological comfort of University students
Authors: M Payer Juvens Li , Ivanova Anna , Ryzhkin Nikolay , Savchenko Yulia , Jiayang Meng
Published: November 2024

See the retraction notice BIO Web of Conferences 138, 00001 (2024), https://doi.org/10.1051/bioconf/202413800001
Two-Way Truth Seeker: A Hybrid Method Using LSTM and BiLSTM to Recognize and Classify Fake News
Authors: Harika Juturu , Jakeer Hussain Shaik
Published: November 2024

In the era of digitization, news spreads, which has turned out to be a big challenge because people seem to be being systematically misinformed. This lowers the credibility of information given on the web and brings threats against social stability BiLSTM and LSTM fusion for fake news classification: Two-way truth seeker. The study of this research focuses on developing an improved advanced model of deep learning that has been trained on a large dataset of labeled news which increases its ability to efficiently detect fake news. The system utilizes the concept of a BiLSTM and LSTM network fusion approach which enables the process to efficiently capture long-range dependency from forward and backward directions to improve the detection of false information. As a result, the presented combination provides improved accuracy and robustness in detecting fake news. Extensive experiments and evaluations were performed using a diverse set of news articles. This project will not only help in the domain of fake news detection but also prove how well-advanced deep learning works on solving the real-world problem.
Immunhämatologische Interferenz im Verlauf einer
Anti-CD47-Antikörpertherapie
Authors: Habicht Cora P. , Hervatin Rafaela , Grüger Daniela , Immenschuh Stephan , Adolph Svenja , Schneeweiß Clemens
Published: November 2024

Eine Reihe von Anti-CD47-Medikamentenkandidaten werden derzeit in klinischen
Studien getestet. Als Checkpoint-Inhibitoren blockieren sie das „Don’t eat
me“-Signal auf Krebszellen, um unter anderem die von Makrophagen vermittelte
Abtötung zu ermöglichen. Da CD47 auch in hoher Dichte auf der Oberfläche von
roten Blutkörperchen exprimiert wird, beeinträchtigt diese Art der Therapie die
immunhämatologische Diagnostik. Mehrere Verfahren zur Umgehung dieser
Interferenz werden derzeit erprobt.

Wir berichten hier über den Verlauf der Interferenz bei einem Patienten mit
akuter myeloischer Leukämie unter Magrolimabtherapie und stellen eine Methode
zur Maskierung von CD47 durch ein neues Reagenz vor, die die Interferenz
behebt.
Living High-Training Low on Mice Bone Parameters Analyzed through
Complex Network Approach
Authors: Beck Wladimir Rafael , Scariot Pedro Paulo Menezes , Papoti Marcelo , Pejon Taciane Maria Melges , Polisel Emanuel Elias Camolese , Manchado-Gobatto Fúlvia Barros , Gobatto Claudio Alexandre
Published: November 2024

The aim of this study was to investigate the effect of 8 weeks of hypoxic
exposition and physical training on healthy mice femur outcomes analyzed through
conventional statistic and complex networks. The mice were divided into four
groups, subjected to physical training (T; 40 min per day at 80% of critical
velocity intensity) or not (N), exposed to hypoxic environment (“Living
High-Training Low” model – LHTL; 18 h per day, FIO2=19.5%; Hyp) or
not (Nor). The complex network analysis performed interactions among parameters
using values of critical “r” of 0.5 by Pearson correlations to edges
construction, with Fruchterman-Reingold layout adopted for graph visualization.
Pondered Degree, Betweenness, and Eigenvector metrics were chosen as centrality
metrics. Two-way ANOVA, t-test and Pearson correlation were used with P<0.05.
Femur phosphorus of T-Hyp was higher than all other groups (P<0.05) and
correlated with bone density (r=0.65; P=0.042), bone mineral density (r=0.67;
P=0.034) and% of mineral material (r=0.66, P=0.038). Overall, the complex
network demonstrated improvements in bone volume, % of mineral material, bone
density, and bone mineral density for T-Hyp over other groups. Association of
physical training and hypoxia improved bone quality for healthy mice.
Otoplasty and Ear Reconstruction Complications
Authors: Buba Cibele M. , Gantous Andres M.
Published: November 2024

Prominauris, often known as prominent ears, is one of the most frequent congenital deformities of the head and neck. Therefore, otoplasty has gained significant popularity and is now one of the most performed procedures in the field of facial plastic surgery.

Reconstructing and correcting ear abnormalities remains a challenging procedure in facial plastic and reconstructive surgery. These deformities, whether congenital or acquired, have a substantial influence on patients' lives and inflict psychological harm. Addressing the deformity and tissue loss will improve the overall quality of life.

Throughout history, various surgical techniques have been reported for treating external ear abnormalities. While most of these surgeries are considered safe, a comprehensive preoperative evaluation and understanding of the different techniques and risks can minimize potential complications.
Sensory–Motor Polyneuropathy in an 11-year- old Girl with a Pathogenic Variant in SMC1A: A Case Report
Authors: De Luisa Angelica , Cesaroni Carlo A. , Pollazzon Marzia , Spagnoli Carlotta , Caraffi Stefano G. , Leon Alberta , Rizzi Susanna , Frattini Daniele , Cavalli Anna , Garavelli Livia , Fusco Carlo
Published: November 2024

Pathogenic variants in the SMC1A gene are often dominant-negative and cause an X-linked form of Cornelia de Lange syndrome (CdLS) with growth retardation and typical facial features. However, rare SMC1A variants cause a developmental and epileptic encephalopathy (DEE) with intractable early-onset epilepsy that is absent in CdLS. Here we describe an 11-year-old girl with epilepsy, walking disorder, and neurodevelopmental disorder. A neurophysiological examination of nerve conduction velocity showed a mixed, sensory–motor, chronic 4-limb polyneuropathy. Whole-exome sequencing identified the variant c.3145C > T p.(Arg1049*) in SMC1A (NM_006306.3), which can be classified as pathogenic. To the best of our knowledge, among 79 individuals with SMC1A-related DEE reported in the literature, altered peripheral nerve conduction has never been described. In this article, we propose that severe sensory–motor polyneuropathy could be an expansion of the SMC1A-related phenotype.
Evaluating Inter- and Intraobserver Agreement on Pectus Carinatum Severity and Treatment Outcomes: A Comparison of Subjective and Objective Assessment Methods
Authors: van Braak Hendrik , de Beer Sjoerd A. , Zwaveling Sander , Oomen Matthijs W. N. , van Heurn L W. Ernest , de Jong Justin R.
Published: November 2024

Background Visual examination is crucial for assessing pectus carinatum (PC) severity and treatment results. This cross-sectional study evaluates the inter- and intraobserver agreement of PC deformities before and after treatment.

Methods Observers examined medical photographs of patients before and after treatment. Primary outcome was inter- and intraobserver agreement on esthetic results after treatment. Secondary outcomes included inter- and intraobserver agreement on severity and symmetry before treatment, differences in esthetic results after Ravitch surgery and dynamic compression bracing (DCS bracing), and the impact of scars, age, and treatment duration on esthetic results.

Results Medical photographs of 201 patients (aged 4–18) were evaluated by five surgeons and five peers. Surgeons and peers demonstrated inadequate (κ < 0.61) interobserver agreement on esthetic results (κ = 0.26, κ = 0.22), severity of PC (κ = 0.43, κ = 0.38), and symmetry (κ = 0.37, surgeons only). Agreement between surgeons and peers on esthetic results (κ = 0.37) and severity before treatment (κ = 0.54) was similarly inadequate. Surgeons and peers demonstrated inadequate intraobserver agreement on esthetic results (κ = 0.49, κ = 0.34), severity of PC (κ = 0.54, κ = 0.48), and symmetry (κ = 0.60, surgeons only). Deformities treated with Ravitch surgery were perceived as more severe but yielded better results. Peers, unlike surgeons, viewed scars as negatively impacting results. No relationship was found between results after treatment and treatment duration (p = 0.682, p = .062) or age (p = 0.205, p = .527).

Conclusions Subjective assessment of PC severity and esthetic results is inconsistent. Three-dimensional scanning could help standardize treatment completion and aid patients and surgeons in determining treatment completion. The psychosocial effects of scars should be addressed when discussing treatment options.
Detection and investigation of quantum diffusion in solid solutions of helium isotopes
Authors: Grigor'ev V. N. , Esel'son B. N. , Mikheev V. A.
Published: November 2024

The phenomenon of quantum diffusion predicted theoretically by Andreev and Lifshitz was detected and investigated experimentally. Measurements of the diffusion coefficient D of He3 impurities in solid He4 by the nuclear magnetic resonance technique established that in the closed-packed hexagonal phase at temperatures below 1°K, D is independent of temperature and its increase is inversely proportional to the He3 concentration. The relationships found indicate a decisive contribution of quantum effects to the diffusion process in weak He3-He4 solutions and correspond to the case when the mobility of the impurity excitations (impuritons) is controlled by their mutual collisions. A comparison of the experimental data with the theory developed permitted estimating the width of the energy band (ΔE) of the impuritons. A continuous transition from vacancion diffusion to impuriton diffusion was recorded and a strong effect of density on the impuriton band width was noted (a 1.5% increase of density leads to an almost twofold decrease of ΔE). Investigations of the diffusion of He3 in the bcc phase of solid helium showed that in solutions containing not more than 2% He3, D decreases exponentially with decrease of temperature in the entire region of existence of the bcc phase, which indicates a vacancion mechanism of diffusion. In more concentrated solutions for which the bcc phase exists down to the lowest investigated temperatures (0.4°K), a complex temperature dependence of the diffusion coefficient was noted. To explain the dependence found, a model is proposed which takes into account the superposition of three mechanisms of diffusion: vacancion and He3-He4 and He3-He3 exchange.
Josephson current in a SNS contact in the presence of a magnetic field
Authors: Antsygina T. N. , Bratus' E. N. , Svidzinskii A. V.
Published: November 2024

The superconducting current through a SNS contact situated in a magnetic field parallel to the interface between the normal metal and superconductor is calculated. It is assumed that the thickness of the normal interlayer d is considerably greater than the coherence length ξ0. The calculation is carried out for a model in which the ordering parameter is constant in each of the superconductors right up to the boundary, while it vanishes stepwise in the normal interlayer. It is likewise assumed that the magnetic field is constant in the normal interlayer and is equal to zero in the superconducting parts of the contact. The calculation is based on lowering the order of the Gor'kov equations for the Green's functions and on formulating the latter by the “splicing” method from two linearly independent solutions. The general results have a complex form, but a simpler expression has been derived for zero temperature: j¯=[jc(0)π2/2eHLd](Φ+2−Φ−2), where j¯ is the current density averaged over the cross section of the contact; jc(0) is the critical current through the contact in the absence of a field; H is the magnetic field; L is the transverse dimension of the contact; the functions Φ± are defined according to the equation Φ±=[(φ0±2eHLd/2π)−1/2]−1/2] in which [x] denotes the fractional part of x, while φ0 is the the field.