bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of the Antidiabetic Activity and Chemical Composition of Geranium collinum Root Extracts—Computational and Experimental Investigations
Authors: Numonov Sodik , Edirs Salamet , Bobakulov Khayrulla , Qureshi Muhammad , Bozorov Khurshed , Sharopov Farukh , Setzer William , Zhao Haiqing , Habasi Maidina , Sharofova Mizhgona , Aisa Haji
Published: June 2017

The root of Geranium collinum Steph is known in Tajik traditional medicine for its hepatoprotective, antioxidant, and anti-inflammatory therapeutic effects. The present study was conducted to evaluate of potential antidiabetic, antioxidant activities, total polyphenolic and flavonoid content from the different extracts (aqueous, aqueous-ethanolic) and individual compounds isolated of the root parts of G. collinum. The 50% aqueous-ethanolic extract possesses potent antidiabetic activity, with IC50 values of 0.10 μg/mL and 0.09 μg/mL for the enzymes protein-tyrosine phosphatase (1B PTP-1B) and α-glucosidase, respectively. Phytochemical investigations of the 50% aqueous-ethanolic extract of G. collinum, led to the isolation of ten pure compounds identified as 3,3′,4,4′-tetra-O-methylellagic acid (1), 3,3′-di-O-methylellagic acid (2), quercetin (3), caffeic acid (4), (+)-catechin (5), (–)-epicatechin (6), (–)-epigallocatechin (7), gallic acid (8), β-sitosterol-3-O-β-d-glucopyranoside (9), and corilagin (10). Their structures were determined based on 1D and 2D NMR and mass spectrometric analyses. Three isolated compounds exhibited strong inhibitory activity against PTP-1B, with IC50 values below 0.9 μg/mL, more effective than the positive control (1.46 μg/mL). Molecular docking analysis suggests polyphenolic compounds such as corilagin, catechin and caffeic acid inhibit PTP-1B and β-sitosterol-3-O-β-d-gluco-pyranoside inhibits α-glucosidase. The experimental results suggest that the biological activity of G. collinum is related to its polyphenol contents. The results are also in agreement with computational investigations. Furthermore, the potent antidiabetic activity of the 50% aqueous-ethanolic extract from G. collinum shows promise for its future application in medicine. To the best of our knowledge, we hereby report, for the first time, the antidiabetic activity of G. collinum.
Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells
Authors: Sonoki Hiroyuki , Tanimae Asami , Endo Satoshi , Matsunaga Toshiyuki , Furuta Takumi , Ichihara Kenji , Ikari Akira
Published: June 2017

Claudin-2 is highly expressed in human lung adenocarcinoma tissues and may be a novel target for cancer chemotherapy because knockdown of claudin-2 decreases cell proliferation. We found that flavonoids including kaempferol, chrysin, and luteolin concentration-dependently decrease claudin-2 expression in lung adenocarcinoma A549 cells. Claudin-2 expression is up-regulated by mitogen-activated protein kinase kinase (MEK)/ extracellular signal-regulated kinase (ERK)/c-Fos and phosphoinositide 3-kinase (PI3K)/Akt/nuclear factor-κB (NF-κB) pathways, but these activities were not inhibited by kaempferol, chrysin, and luteolin. Promoter deletion assay using luciferase reporter vector showed that kaempferol and luteolin inhibit the function of transcriptional factor that binds to the region between −395 and −144 of claudin-2 promoter. The decrease in promoter activity was suppressed by mutation in signal transducers and activators of transcription (STAT)-binding site, which is located between −395 and −144. The phosphorylation level of STAT3 was not decreased, but the binding of STAT3 on the promoter region is suppressed by kaempferol and luteolin in chromatin immunoprecipitation assay. The inhibition of cell proliferation caused by kaempferol and luteolin was partially recovered by ectopic claudin-2 expression. Taken together, kaempferol and luteolin decreased claudin-2 expression and proliferation in A549 cells mediated by the inhibition of binding of STAT3 on the promoter region of claudin-2. The intake of foods and nutrients rich in these flavonoids may prevent lung adenocarcinoma development.
Strawberry-Based Cosmetic Formulations Protect Human Dermal Fibroblasts against UVA-Induced Damage
Authors: Gasparrini Massimiliano , Forbes-Hernandez Tamara , Afrin Sadia , Reboredo-Rodriguez Patricia , Cianciosi Danila , Mezzetti Bruno , Quiles Josè , Bompadre Stefano , Battino Maurizio , Giampieri Francesca
Published: June 2017

Extreme exposure of skin to Ultraviolet A (UVA)-radiation may induce a dysregulated production of reactive oxygen species (ROS) which can interact with cellular biomolecules leading to oxidative stress, inflammation, DNA damage, and alteration of cellular molecular pathways, responsible for skin photoaging, hyperplasia, erythema, and cancer. For these reasons, the use of dietary natural bioactive compounds with remarkable antioxidant activity could be a strategic tool to counteract these UVA-radiation-caused deleterious effects. Thus, the purpose of the present work was to test the efficacy of strawberry (50 μg/mL)-based formulations supplemented with Coenzyme Q10 (100 μg/mL) and sun protection factor 10 in human dermal fibroblasts irradiated with UVA-radiation. The apoptosis rate, the amount of intracellular reactive oxygen species (ROS) production, the expression of proteins involved in antioxidant and inflammatory response, and mitochondrial functionality were evaluated. The results showed that the synergic topical use of strawberry and Coenzyme Q10 provided a significant (p < 0.05) photoprotective effect, reducing cell death and ROS, increasing antioxidant defense, lowering inflammatory markers, and improving mitochondrial functionality. The obtained results suggest the use of strawberry-based formulations as an innovative, natural, and useful tool for the prevention of UVA exposure-induced skin diseases in order to decrease or substitute the amount of synthetic sunscreen agents.
Lifestyle Patterns and Weight Status in Spanish Adults: The ANIBES Study
Authors: Pérez-Rodrigo Carmen , Gianzo-Citores Marta , Gil Ángel , González-Gross Marcela , Ortega Rosa , Serra-Majem Lluis , Varela-Moreiras Gregorio , Aranceta-Bartrina Javier
Published: June 2017

Limited knowledge is available on lifestyle patterns in Spanish adults. We investigated dietary patterns and possible meaningful clustering of physical activity, sedentary behavior, sleep time, and smoking in Spanish adults aged 18–64 years and their association with obesity. Analysis was based on a subsample (n = 1617) of the cross-sectional ANIBES study in Spain. We performed exploratory factor analysis and subsequent cluster analysis of dietary patterns, physical activity, sedentary behaviors, sleep time, and smoking. Logistic regression analysis was used to explore the association between the cluster solutions and obesity. Factor analysis identified four dietary patterns, “Traditional DP”, “Mediterranean DP”, “Snack DP” and “Dairy-sweet DP”. Dietary patterns, physical activity behaviors, sedentary behaviors, sleep time, and smoking in Spanish adults aggregated into three different clusters of lifestyle patterns: “Mixed diet-physically active-low sedentary lifestyle pattern”, “Not poor diet-low physical activity-low sedentary lifestyle pattern” and “Poor diet-low physical activity-sedentary lifestyle pattern”. A higher proportion of people aged 18–30 years was classified into the “Poor diet-low physical activity-sedentary lifestyle pattern”. The prevalence odds ratio for obesity in men in the “Mixed diet-physically active-low sedentary lifestyle pattern” was significantly lower compared to those in the “Poor diet-low physical activity-sedentary lifestyle pattern”. Those behavior patterns are helpful to identify specific issues in population subgroups and inform intervention strategies. The findings in this study underline the importance of designing and implementing interventions that address multiple health risk practices, considering lifestyle patterns and associated determinants.
Identifying Eating Occasion-Based Opportunities to Improve the Overall Diets of Australian Adolescents
Authors: Fayet-Moore Flavia , McConnell Andrew , Kim Jean , Mathias Kevin
Published: June 2017

Adolescents in Australia have a poor dietary intake, leading to large numbers of them being at risk for inadequate intake of micronutrients, and excessive intake of less healthful dietary components. This study examined dietary intakes at multiple eating occasions to identify opportunities for more targeted recommendations and strategies to improve dietary intakes among adolescents. Data from the first 24-h recall of 14–18 years old in the 2011–2012 National Nutrition and Physical Activity Survey were analysed (n = 772). Participant-defined eating occasions were classified as breakfast, lunch, dinner or other eating occasions combined. The mean percent contribution to the total day intake of top shortfall nutrients (calcium, magnesium, vitamin A, iron), discretionary calories, saturated fat, free sugars and sodium, as well as nutrient density, the foods consumed and the percent of consumers at each eating occasion, were calculated. Breakfast had the lowest prevalence of consumers (81%), contributed the least to total daily energy (14.6%) and almost a quarter of daily calcium and iron. Other eating occasions combined contributed 47.5% of free sugars and were top contributors of daily calcium (34.6%) and magnesium (31.7%). Discretionary foods contributed 32.4% of the energy at lunch, and the sodium content at lunch was 415 mg/1000 kJ. Key opportunities identified for adolescents were to increase breakfast consumption, given the high nutrient densities of breakfasts consumed; improve overall lunch quality, particularly the sodium content; promote the intake of milk, fruit and a variety of vegetables at both lunch and dinner; maintain healthful choices at in-between meal eating occasions while focusing on decreasing the intake of discretionary foods.
In Vitro and In Vivo Studies of Alar-Nasal Cartilage Using Autologous Micro-Grafts: The Use of the Rigenera® Protocol in the Treatment of an Osteochondral Lesion of the Nose
Authors: Ceccarelli Gabriele , Gentile Pietro , Marcarelli Marco , Balli Martina , Ronzoni Flavio , Benedetti Laura , Cusella De Angelis Maria
Published: June 2017

Cartilage defects represent a serious problem due to the poor regenerative properties of this tissue. Regarding the nose, nasal valve collapse is associated with nasal blockage and persistent airway obstruction associated with a significant drop in the quality of life for patients. In addition to surgical techniques, several cell-based tissue-engineering strategies are studied to improve cartilage support in the nasal wall, that is, to ameliorate wall insufficiency. Nevertheless, there are no congruent data available on the benefit for patients during the follow-up time. In this manuscript, we propose an innovative approach in the treatment of cartilage defects in the nose (nasal valve collapse) based on autologous micro-grafts obtained by mechanical disaggregation of a small portion of cartilage tissue (Rigenera® protocol). In particular, we first analyzed in vitro murine and human cartilage micro-grafts; secondly, we analyzed the clinical results of a patient with pinched nose deformity treated with autologous micro-grafts of chondrocytes obtained by Rigenera® protocol. The use of autologous micro-graft produced promising results in surgery treatment of cartilage injuries and could be safely and easily administrated to patients with cartilage tissue defects.
The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications
Authors: Ayerst Bethanie I. , Merry Catherine L.R. , Day Anthony J.
Published: June 2017

High sulfation, low cost, and the status of heparin as an already FDA- and EMA- approved product, mean that its inclusion in tissue engineering (TE) strategies is becoming increasingly popular. However, the use of heparin may represent a naïve approach. This is because tissue formation is a highly orchestrated process, involving the temporal expression of numerous growth factors and complex signaling networks. While heparin may enhance the retention and activity of certain growth factors under particular conditions, its binding ‘promiscuity’ means that it may also inhibit other factors that, for example, play an important role in tissue maintenance and repair. Within this review we focus on articular cartilage, highlighting the complexities and highly regulated processes that are involved in its formation, and the challenges that exist in trying to effectively engineer this tissue. Here we discuss the opportunities that glycosaminoglycans (GAGs) may provide in advancing this important area of regenerative medicine, placing emphasis on the need to move away from the common use of heparin, and instead focus research towards the utility of specific GAG preparations that are able to modulate the activity of growth factors in a more controlled and defined manner, with less off-target effects.
Teaching Prescribing: Just What the Doctor Ordered? A Thematic Analysis of the Views of Newly Qualified Doctors
Authors: Hansen Christina , Walsh Elaine , Bradley Colin , Sahm Laura
Published: June 2017

Undergraduate medical education has been criticised for failing to adequately prepare doctors for the task of prescribing. Pharmacists have been shown to improve medication use in hospitals. This study aims to elicit the views of intern doctors on the challenges of prescribing, and to suggest changes in education to enhance prescribing practice and potential role of the pharmacist. Semi-structured, qualitative interviews were conducted with intern doctors in their first year post qualification in an Irish hospital. Data collection was conducted until no new themes emerged and thematic analysis was performed. Thirteen interviews took place. Interns described training in practical prescribing as limited and felt the curriculum failed to convey the reality of actual prescribing. Pharmacists were perceived to be a useful, but underutilised, information source in the prescribing process. They requested an earlier introduction, and repeated exposure, to prescribing, and suggested the involvement of peers and pharmacists in this teaching. Intern doctors reported difficulties in applying knowledge gained in medical school to clinical practice. New strategies are needed to enhance the clinical relevance of the medical curriculum by rethinking the learning outcomes regarding prescribing practice and the involvement of pharmacists in prescribing education.
The Unique Role of the ECERIFERUM2-LIKE Clade of the BAHD Acyltransferase Superfamily in Cuticular Wax Metabolism
Authors: Haslam Tegan , Gerelle Wesley , Graham Sean , Kunst Ljerka
Published: June 2017

The elongation of very-long-chain fatty acids is a conserved process used for the production of many metabolites, including plant cuticular waxes. The elongation of precursors of the most abundant cuticular wax components of some plants, however, is unique in requiring ECERIFERUM2-LIKE (CER2-LIKE) proteins. CER2-LIKEs are a clade within the BAHD superfamily of acyltransferases. They are known to be required for cuticular wax production in both Arabidopsis and maize based on mutant studies. Heterologous expression of Arabidopsis and rice CER2-LIKEs in Saccharomyces cerevisiae has demonstrated that they modify the chain-length specificity of elongation when paired with particular condensing enzymes. Despite sequence homology, CER2-LIKEs are distinct from the BAHD superfamily in that they do not appear to use acyl transfer activity to fulfill their biological function. Here, we review the discovery and characterization of CER2-LIKEs, propose several models to explain their function, and explore the importance of CER2-LIKE proteins for the evolution of plant cuticles.
Erratum: pH Sensitive Hydrogels in Drug Delivery: Brief History, Properties, Swelling, and Release Mechanism, Material Selection and Applications. Polymers 2017, 9, 137
Authors: Rizwan Muhammad , Yahya Rosiyah , Hassan Aziz , Yar Muhammad , Azzahari Ahmad , Selvanathan Vidhya , Sonsudin Faridah , Abouloula Cheyma
Published: June 2017

The authors wish to make a change to their published paper [1]. [...]
Icons of Just Is: Justice, Suffering, and the Artwork of Samuel Bak
Authors: Phillips Gary
Published: June 2017

This paper examines select paintings by Holocaust survivor and painter Samuel Bak from his recent Just Is series. The essay explores ways Bak’s art bears witness to suffering. He creatively interrogates and reanimates the iconic figure of Lady Justice and the biblical principle of the lex talionis (“eye for an eye”) in order to fashion alternative icons fit for an age of atrocity and loss. Bak’s artwork gives visual expression to Theodor Adorno’s view of the precariousness of art after Auschwitz. It is art’s responsibility to attend to the burden of real suffering experiences (the burden of the empirical) and to think in contradictions, which renders art both adequate and inadequate in standing up against the injustice of other’s suffering. Through inventive juxtaposition of secular and sacred symbols, Bak displays the paradox of representation after the Holocaust and art’s precarious responsibility giving voice to suffering. Bak fashions visual spaces in which barbarity and beauty coincide and collide. He invites viewers into this space and into dialogue about justice’s standing and promises. Do Bak's remade icons of Just Is lament a permanent loss of justice and peace, or do they point tentatively to possibilities of life lived in a damaged world with an alternative Just Is? Bak’s artwork prompts such vexing questions for his viewers to contemplate and leaves them to decide what must be done.
Evaluating Site-Specific and Generic Spatial Models of Aboveground Forest Biomass Based on Landsat Time-Series and LiDAR Strip Samples in the Eastern USA
Authors: Deo Ram , Russell Matthew , Domke Grant , Andersen Hans-Erik , Cohen Warren , Woodall Christopher
Published: June 2017

Large-area assessment of aboveground tree biomass (AGB) to inform regional or national forest monitoring programs can be efficiently carried out by combining remotely sensed data and field sample measurements through a generic statistical model, in contrast to site-specific models. We integrated forest inventory plot data with spatial predictors from Landsat time-series imagery and LiDAR strip samples at four sites across the eastern USA—Minnesota (MN), Maine (ME), Pennsylvania-New Jersey (PANJ) and South Carolina (SC)—in statistical modeling frameworks to analyze the performance of generic (all sites combined) versus site-specific models. The major objective was to evaluate the prediction accuracy of generic and site-specific models when applied to particular sites. Pixel-level polynomial model fitting was applied to the time-series of near-anniversary date Landsat variables to obtain projected metrics in the target year 2014 for which LiDAR strip samples were available. Two forms of models based on ordinary least-squares multiple linear regressions (MLR) and the random forest (RF) machine learning approach were developed for each site and for the pooled (i.e., generic) reference data frame. The models were evaluated using national forest inventory (NFI) data for the USA. We observed stronger fit statistics with the MLR than with RF for both the site-specific and the generic models. The proportions of variances explained (adjusted R2) with the site-specific models were 0.86, 0.78, 0.82 and 0.92 for ME, MN, PANJ and SC, respectively while the generic model had adjusted R2 = 0.85. A test of statistical equivalence of observed and predicted AGB for the NFI locations did not reveal equivalence with any of the models, possibly due to the different resolutions of the observed and predicted data. In contrast, predictions by the generic and site-specific models were equivalent. We conclude that a generic model provides accuracies comparable to the site-specific models for large-area AGB assessment across our study sites in the eastern USA.
Envisat RA-2 Individual Echoes: A Unique Dataset for a Better Understanding of Inland Water Altimetry Potentialities
Authors: Abileah Ron , Scozzari Andrea , Vignudelli Stefano
Published: June 2017

The exploitation of synthetic aperture properties in nadir-looking radars is opening new scenarios in the framework of satellite radar altimetry. Both recent and upcoming missions including Cryosat-2, Sentinel-3, Sentinel-6 and SWOT take benefit from the coherent processing of radar data, aimed at improving range measurements in particular contexts, such as ice, open ocean, coastal zone, and even inland waters. This work investigates the possibilities offered by current and future satellite radar altimetry missions for the study of inland water bodies, probing into the peculiarities of the expected radar returns and their potential usage. In this regard, signals collected by the RA-2 instrument (Radar Altimeter 2) onboard the Envisat mission offer an unprecedented possibility, even with a relatively low pulse repetition frequency, to analyze the peculiarities of actual signals for detecting and ranging small water surfaces. In particular, the RA-2 instrument offers a global archive of Individual Echoes (IEs), collected at the native sampling rate of 1795 Hz, in addition to the 18 Hz data obtained by incoherent averaging, which are typically delivered to the users as standard products. RA-2 shares with future radar platforms such as Sentinel-6 a continuous and interleaved working modality, as was recommended by the scientific community in designing next missions’ requirements. This is a further reason to consider the usage of RA-2 IEs as particularly attractive. Whilst only available for a small percentage of the earth’s surface, sufficient IE data exist to study the height retrieval capability of these echoes, in particular for what concerns small water bodies, where we show that enough coherence is exhibited for focusing relatively narrow surfaces and range them correctly. A peculiar aspect of this work lies in the assumption that most of the returned echoes (in RA-2 IEs) are specular. A theoretical framework is developed according to this assumption, which is validated by investigating real RA-2 data and observing their related specular features. In particular, we discuss how specular echoes are expected to be very common in inland altimetry, and are most often associated with small to medium size lakes and rivers. This paper illustrates the expected electromagnetic behavior of specular water targets by exploiting the classical radar cross-section (RCS) theory for specular surfaces. Results from the model are compared with real IE data in three selected case studies, regarding two rivers of variable width and one flood plain, in order to check different hydrological regimes. The model very closely matches the data in all cases, making the results of this validation activity very promising. In particular, we demonstrate the feasibility of using satellite radar altimetry in rivers much smaller than what was considered possible until now.
Gold Electrodes Modified with Calix[4]arene for Electrochemical Determination of Dopamine in the Presence of Selected Neurotransmitters
Authors: Kurzątkowska Katarzyna , Sayin Serkan , Yilmaz Mustafa , Radecka Hanna , Radecki Jerzy
Published: June 2017

Here, we present an electrochemical sensor based on gold electrodes modified with calix[4]arene functionalized with carboxypiperidino groups at the upper rim. It has been demonstrated that these groups are involved in a complex formation with dopamine (DA) on the surface of gold electrodes. The supramolecular complex calix[4]arene–DA created on the gold electrode surface has been characterized electrochemically and the measuring conditions have been optimized. The presented sensor displayed a detection limit in the pM range. The DA determination was performed successfully in the presence of ascorbic acid, uric acid and selected neurotransmitters.
A Multi-Parametric Device with Innovative Solid Electrodes for Long-Term Monitoring of pH, Redox-Potential and Conductivity in a Nuclear Waste Repository
Authors: Daoudi Jordan , Betelu Stephanie , Tzedakis Theodore , Bertrand Johan , Ignatiadis Ioannis
Published: June 2017

We present an innovative electrochemical probe for the monitoring of pH, redox potential and conductivity in near-field rocks of deep geological radioactive waste repositories. The probe is composed of a monocrystalline antimony electrode for pH sensing, four AgCl/Ag-based reference or Cl− selective electrodes, one Ag2S/Ag-based reference or S2− selective electrode, as well as four platinum electrodes, a gold electrode and a glassy-carbon electrode for redox potential measurements. Galvanostatic electrochemistry impedance spectroscopy using AgCl/Ag-based and platinum electrodes measure conductivity. The use of such a multi-parameter probe provides redundant information, based as it is on the simultaneous behaviour under identical conditions of different electrodes of the same material, as well as on that of electrodes made of different materials. This identifies the changes in physical and chemical parameters in a solution, as well as the redox reactions controlling the measured potential, both in the solution and/or at the electrode/solution interface. Understanding the electrochemical behaviour of selected materials thus is a key point of our research, as provides the basis for constructing the abacuses needed for developing robust and reliable field sensors.
Microcontact Imprinted Plasmonic Nanosensors: Powerful Tools in the Detection of Salmonella paratyphi
Authors: Perçin Işık , Idil Neslihan , Bakhshpour Monireh , Yılmaz Erkut , Mattiasson Bo , Denizli Adil
Published: June 2017

Identification of pathogenic microorganisms by traditional methods is slow and cumbersome. Therefore, the focus today is on developing new and quicker analytical methods. In this study, a Surface Plasmon Resonance (SPR) sensor with a microcontact imprinted sensor chip was developed for detecting Salmonella paratyphi. For this purpose, the stamps of the target microorganism were prepared and then, microcontact S. paratyphi-imprinted SPR chips were prepared with the functional monomer N-methacryloyl-L-histidine methyl ester (MAH). Characterization studies of the SPR chips were carried out with ellipsometry and scanning electron microscopy (SEM). The real-time Salmonella paratyphi detection was performed within the range of 2.5 × 106–15 × 106 CFU/mL. Selectivity of the prepared sensors was examined by using competing bacterial strains such as Escherichia coli, Staphylococcus aureus and Bacillus subtilis. The imprinting efficiency of the prepared sensor system was determined by evaluating the responses of the SPR chips prepared with both molecularly imprinted polymers (MIPs) and non-imprinted polymers (NIPs). Real sample experiments were performed with apple juice. The recognition of Salmonella paratyphi was achieved using these SPR sensor with a detection limit of 1.4 × 106 CFU/mL. In conclusion, SPR sensor has the potential to serve as an excellent candidate for monitoring Salmonella paratyphi in food supplies or contaminated water and clearly makes it possible to develop rapid and appropriate control strategies.
QuickCash: Secure Transfer Payment Systems
Authors: Alhothaily Abdulrahman , Alrawais Arwa , Song Tianyi , Lin Bin , Cheng Xiuzhen
Published: June 2017

Payment systems play a significant role in our daily lives. They are an important driver of economic activities and a vital part of the banking infrastructure of any country. Several current payment systems focus on security and reliability but pay less attention to users’ needs and behaviors. For example, people may share their bankcards with friends or relatives to withdraw money for various reasons. This behavior can lead to a variety of privacy and security issues since the cardholder has to share a bankcard and other sensitive information such as a personal identification number (PIN). In addition, it is commonplace that cardholders may lose their cards, and may not be able to access their accounts due to various reasons. Furthermore, transferring money to an individual who has lost their bankcard and identification information is not a straightforward task. A user-friendly person-to-person payment system is urgently needed to perform secure and reliable transactions that benefit from current technological advancements. In this paper, we propose two secure fund transfer methods termed QuickCash Online and QuickCash Offline to transfer money from peer to peer using the existing banking infrastructure. Our methods provide a convenient way to transfer money quickly, and they do not require using bank cards or any identification card. Unlike other person-to-person payment systems, the proposed methods do not require the receiving entity to have a bank account, or to perform any registration procedure. We implement our QuickCash payment systems and analyze their security strengths and properties.
Detection Performance Improvement of Distributed Vibration Sensor Based on Curvelet Denoising Method
Authors: Qin Zengguang , Chen Hui , Chang Jun
Published: June 2017

A curvelet denoising method has been proposed to reduce the time domain noise to improve the detection performance in the distributed fiber vibration sensing system based on phase-sensitive optical time domain reflectometry. The raw Rayleigh backscattering traces are regarded as a gray image and the random noise can be eliminated by the curvelet transform; hence, the amplitude difference induced by the external vibration can be extracted. The detection of a vibration event with 10 m spatial resolution along a 4 km single mode fiber is demonstrated. The signal-to-noise ratio (SNR) of location information for 50 Hz and 1 kHz vibration based on this new method increases to as high as 7.8 dB and 8.0 dB, respectively, compared to the conventional method, showing the remarkable denoising capability of this new approach.
Design and Fabrication of Piezoelectric Micromachined Ultrasound Transducer (pMUT) with Partially-Etched ZnO Film
Authors: Li Junhong , Ren Wei , Fan Guoxiang , Wang Chenghao
Published: June 2017

A square piezoelectric composite diaphragm was analyzed by the finite element method to enhance the sensitivity of a piezoelectric micromachined ultrasound transducer (pMUT). The structures of electrode and piezoelectric film were optimized and a centric electrode was designed to avoid the counteraction of stress in the centre and edges. In order to further improve the sensitivity; a pMUT with partially-etched piezoelectric film was adopted. The receive and transmit sensitivities of the pMUT were analyzed in details. The receive sensitivity of pMUT with partially-etched ZnO film is 3.3 dB or 6.8 dB higher than those with a centric and whole electrode, respectively; and the amplitude of a partially-etched ZnO film pMUT under a certain voltage is 5.5 dB and 30 dB higher than those with centric and whole electrode separately. Two pMUT-based ZnO films were fabricated by micromachining technology and their receive and transmit sensitivities were tested. The ZnO films deposited by direct current (DC) magnetron sputtering exhibit a densely packed structure with columnar crystallites. The test results show that the structure of the square diaphragm with partially-etched piezoelectric layer can significantly improve the transducer sensitivity. The receive sensitivity and transmit sensitivity are −238.35 dB (ref. 1 V/μPa) and 150.42 dB (ref. 1 μPa/V); respectively.
A Framework for Learning Analytics Using Commodity Wearable Devices
Authors: Lu Yu , Zhang Sen , Zhang Zhiqiang , Xiao Wendong , Yu Shengquan
Published: June 2017

We advocate for and introduce LEARNSense, a framework for learning analytics using commodity wearable devices to capture learner’s physical actions and accordingly infer learner context (e.g., student activities and engagement status in class). Our work is motivated by the observations that: (a) the fine-grained individual-specific learner actions are crucial to understand learners and their context information; (b) sensor data available on the latest wearable devices (e.g., wrist-worn and eye wear devices) can effectively recognize learner actions and help to infer learner context information; (c) the commodity wearable devices that are widely available on the market can provide a hassle-free and non-intrusive solution. Following the above observations and under the proposed framework, we design and implement a sensor-based learner context collector running on the wearable devices. The latest data mining and sensor data processing techniques are employed to detect different types of learner actions and context information. Furthermore, we detail all of the above efforts by offering a novel and exemplary use case: it successfully provides the accurate detection of student actions and infers the student engagement states in class. The specifically designed learner context collector has been implemented on the commodity wrist-worn device. Based on the collected and inferred learner information, the novel intervention and incentivizing feedback are introduced into the system service. Finally, a comprehensive evaluation with the real-world experiments, surveys and interviews demonstrates the effectiveness and impact of the proposed framework and this use case. The F1 score for the student action classification tasks achieve 0.9, and the system can effectively differentiate the defined three learner states. Finally, the survey results show that the learners are satisfied with the use of our system (mean score of 3.7 with a standard deviation of 0.55).
Instrumented Compliant Wrist with Proximity and Contact Sensing for Close Robot Interaction Control
Authors: Laferrière Pascal , Payeur Pierre
Published: June 2017

Compliance has been exploited in various forms in robotic systems to allow rigid mechanisms to come into contact with fragile objects, or with complex shapes that cannot be accurately modeled. Force feedback control has been the classical approach for providing compliance in robotic systems. However, by integrating other forms of instrumentation with compliance into a single device, it is possible to extend close monitoring of nearby objects before and after contact occurs. As a result, safer and smoother robot control can be achieved both while approaching and while touching surfaces. This paper presents the design and extensive experimental evaluation of a versatile, lightweight, and low-cost instrumented compliant wrist mechanism which can be mounted on any rigid robotic manipulator in order to introduce a layer of compliance while providing the controller with extra sensing signals during close interaction with an object’s surface. Arrays of embedded range sensors provide real-time measurements on the position and orientation of surfaces, either located in proximity or in contact with the robot’s end-effector, which permits close guidance of its operation. Calibration procedures are formulated to overcome inter-sensor variability and achieve the highest available resolution. A versatile solution is created by embedding all signal processing, while wireless transmission connects the device to any industrial robot’s controller to support path control. Experimental work demonstrates the device’s physical compliance as well as the stability and accuracy of the device outputs. Primary applications of the proposed instrumented compliant wrist include smooth surface following in manufacturing, inspection, and safe human-robot interaction.
A Novel Sensor Based on a Single-Pixel Microwave Radiometer for Warm Object Counting: Concept Validation and IoT Perspectives
Authors: Alimenti Federico , Bonafoni Stefania , Roselli Luca
Published: June 2017

Controlled measurements by a low-cost single-pixel microwave radiometer operating at 12.65 GHz were carried out to assess the detection and counting capability for targets warmer than the surroundings. The adopted reference test targets were pre-warmed water and oil; and a hand, both naked and wearing a glove. The results showed the reliability of microwave radiometry for counting operations under controlled conditions, and its effectiveness at detecting even warm targets masked by unheated dielectric layers. An electromagnetic model describing the scenario sensed by the radiometer antenna is proposed, and comparison with the experimental observations shows a good agreement. The measurements prove that reliable counting is enabled by an antenna temperature increment, for each target sample added, of around 1 K. Starting from this value, an analysis of the antenna filling factor was performed to provide an instrument useful for evaluating real applicability in many practical situations. This study also allows the direct people counting problem to be addressed, providing preliminary operational indications, reference numbers and experimental validation.
A Novel Approach to Measuring Muscle Mechanics in Vehicle Collision Conditions
Authors: Krašna Simon , Đorđević Srđan , Hribernik Marija , Trajkovski Ana
Published: June 2017

The aim of the study was to evaluate a novel approach to measuring neck muscle load and activity in vehicle collision conditions. A series of sled tests were performed on 10 healthy volunteers at three severity levels to simulate low-severity frontal impacts. Electrical activity—electromyography (EMG)—and muscle mechanical tension was measured bilaterally on the upper trapezius. A novel mechanical contraction (MC) sensor was used to measure the tension on the muscle surface. The neck extensor loads were estimated based on the inverse dynamics approach. The results showed strong linear correlation (Pearson’s coefficient = 0.821) between the estimated neck muscle load and the muscle tension measured with the MC sensor. The peak of the estimated neck muscle force delayed 0.2 ± 30.6 ms on average vs. the peak MC sensor signal compared to the average delay of 61.8 ± 37.4 ms vs. the peak EMG signal. The observed differences in EMG and MC sensor collected signals indicate that the MC sensor offers an additional insight into the analysis of the neck muscle load and activity in impact conditions. This approach enables a more detailed assessment of the muscle-tendon complex load of a vehicle occupant in pre-impact and impact conditions.
A Novel Method for Selecting Protective Seam against Coal and Gas Outburst: A Case Study of Wangjiazhai Coal Mine in China
Authors: Guowei Dong , Yinhui Zou
Published: June 2017

Protective seam mining is a major and critical regional measure to prevent coal and gas outbursts (CGO) in coal mines. In this study, a novel method for selecting protective seam against coal and gas outburst was studied on the basis of gas geology and rock strata control theories and principles for protective seam mining and relevant regulations, which is that theories of gas geology were used to assess the outburst risk inherent in different seams of this mine, and then make preliminary selection of protective seams, and the technical feasibility of the proposed selection method was then analyzed using the theories and principles for protective seam mining and relevant regulations. The case application study results show that the extraction of the upper protective seam (UPS) caused significant decreases in the predicative indicators of outburst risk in the outburst-prone seam and thereby prevented CGO, and the novel method can provide a theoretical basis for selecting protective seam against CGO.
The Role of Company-Cause Fit and Company Involvement in Consumer Responses to CSR Initiatives: A Meta-Analytic Review
Authors: Zasuwa Grzegorz
Published: June 2017

The marketing literature suggests that company-cause fit is of key importance to developing a successful socially responsible initiative. However, controversy exists regarding the level of this fit. While some studies report that high fit between a company and a cause has beneficial effects on consumer responses to such efforts, other research identifies negative impacts. This paper aims to obtain a deeper insight into this issue by examining the moderating role of company involvement in a cause. A meta-analysis of 51 experimental studies, yielding a total sample size of 11,335 subjects, shows that company-cause fit influences consumer responses to CSR initiatives most positively when a company with a positive reputation is highly involved in a cause, that is, when the company donates at least products. If such a company provides its beneficiary with only monetary contributions (i.e., low involvement), the effects of fit are significantly less influential.
Effects of Understory Liana Trachelospermum jasminoides on Distributions of Litterfall and Soil Organic Carbon in an Oak Forest in Central China
Authors: Liu Yanchun , Shang Qing , Zhang Bo , Zhang Kesheng , Luan Junwei
Published: June 2017

Liana constitutes an important structural and functional component in many forest ecosystems and has profound impacts on forest carbon (C) cycling. However, whether and how liana regulates spatial distributions of litterfall and soil organic C are still poorly understood. To address this critical knowledge gap, we investigated litterfall composition and soil physicochemical characteristics in stands with different densities of liana (Trachelospermum jasminoides (Lindl.) Lem.). Both fresh and decomposed leaf litters were greater in the stands with high density of the liana species T. jasminoides. More liana covered stands also had higher soil respiration rate, soil organic C, and total nitrogen than those with less liana. The findings demonstrate that understory liana can regulate litterfall distribution and thus soil organic C, suggesting that the influences of understory liana on belowground ecological processes should be considered while assessing the role of liana in forest ecosystems.
Sustainable Governance of Organic Food Production When Market Forecast Is Imprecise
Authors: Han Guanghua , Pu Xujin , Fan Bo
Published: June 2017

During the past few years, the market for organic food has been experiencing rapid growth. However, the market demand for organic food typically fluctuates due to its seasonal nature and customized characteristics, and it remains fairly difficult to precisely forecast market demand prior to the selling season. Forecast bias usually creates inefficiency in an organic food producer’s production plan and results in a substantial amount of waste. Thus, this paper studies how much an organic food producer is likely to lose with a certain level of forecast bias and investigates whether forecast bias necessarily results in an improper production plan. Finally, we calculate the maximum potential profit loss rate when the organic food producer determines how much to produce based on his forecasted demand, which we believe will be instructive for organic food producers in making production decisions. The target problem is formulated by a newsvendor model and solved using a tolerant analysis approach. We find that an organic food producer can still find the optimal solution only if his forecast bias is under a certain threshold. However, if the organic food producer’s forecast bias is beyond the threshold, he will probably make a sub-optimal production decision and potentially experience a profit loss. Subsequently, we analytically calculate an organic producer’s maximum potential profit loss rate for any given level of forecast bias. Examples are employed to numerically illustrate the main findings.
Decoupling Agricultural Nonpoint Source Pollution from Crop Production: A Case Study of Heilongjiang Land Reclamation Area, China
Authors: Yang Qingshan , Liu Jie , Zhang Yu
Published: June 2017

Modern agriculture often leads to nonpoint source pollution. From the perspective of a decoupling analysis, this research evaluates the relationship between crop production and agricultural nonpoint source pollution (via fertilizer application), using the Heilongjiang land reclamation area as a case study. As it is the largest commodity grain base and green food base in China, more than 80% of water pollution in this area comes from fertilizer application. This study adopts an export coefficient model to hindcast nitrogen loss delivered to surface water via fertilizer application and conduct a further analysis of decoupling agricultural nonpoint source pollution from crop production. The results indicated that weak decoupling frequently occurred. However, this tendency was not steady in the period 2001–2012, and weak decoupling was typical in each branch based on the average value. Regarding the example of decoupling agricultural nonpoint source pollution from rice production, weak decoupling occurred more often, but this tendency was not steady over time. In addition, expansive coupling occurred in 2006, 2010 and 2012, and there were no definite signs of it improving. All branches, except for the Suihua branch, reached the degree of weak decoupling. A basic fact is that a decoupling tendency and environmental deterioration coexist in both the past and present. The decoupling analysis will contribute to localized strategies for sustainable agricultural development.
HAdV-C6 Is a More Relevant Challenge Virus than HAdV-C5 for Testing Antiviral Drugs with the Immunosuppressed Syrian Hamster Model
Authors: Toth Karoly , Spencer Jacqueline , Ying Baoling , Tollefson Ann , Wold William
Published: June 2017

Adenovirus infections of immunocompromised patients can cause a severe multi-organ disease that often results in the patients’ death. Presently, there are no drugs specifically approved to treat adenovirus infections, and clinicians resort to the off-label use of antivirals that are approved to treat other DNA virus infections, most frequently cidofovir (CDV). CDV, however, has considerable nephrotoxicity, thus it is recommended only for the most severe cases of adenovirus infections. To facilitate the development of effective, non-toxic antivirals against adenovirus, we have developed a permissive animal model based on the Syrian hamster that can be used to test the efficacy of antiviral compounds. Here, we show that in the hamster model, HAdV-C6 is a more useful challenge virus than the previously described HAdV-C5, because it is filtered out by tissue macrophages to a lesser extent. HAdV-C6 has a 10-fold lower LD50 in hamsters than HAdV-C5 and the pathology is caused by virus replication to a larger extent. We show that valganciclovir (VGCV), a drug that was shown to be active against intravenous HAdV-C5 infection previously, is efficacious against HAdV-C6 when administered either prophylactically or therapeutically. Further, we show for the first time that VGCV, and to a lesser extent CDV, can be used to treat respiratory adenovirus infections in the hamster model. These results extend the utility of the hamster model, and demonstrate the efficacy of two drugs available for clinicians to treat adenovirus infections.