bluuebunny/crossref_metadata_2025 huggingface dataset:
Basculement confessionnel et engagement politique au début des guerres de Religion : le cas d’Antoine de Croÿ, prince de Porcien
Authors: Pascucci Tomaso
Published: October 2018

Les raisons qui ont présidé à l’adhésion d’une partie importante de la noblesse française à la cause réformée entre la fin du règne d’Henri II et le début du règne de Charles IX demeurent une problématique peu abordée, les sources susceptibles d’éclairer les choix confessionnels opérés par la noblesse protestante étant rares. Néanmoins, il existe des exceptions, plus nombreuses qu’on ne saurait imaginer. C’est notamment le cas d’Antoine de Croÿ, prince de Porcien, dont le parcours mérite d’être réexaminé en raison du rôle important joué par ce personnage dans le camp huguenot. Cet article entend tout particulièrement approfondir le cheminement et les motivations de son engagement au service de la cause réformée. Une analyse de sources éditées et inédites semble indiquer que si le prince de Porcien hésite initialement à manifester publiquement sa conversion au credo protestant, il embrasse ensuite de façon inébranlable la lutte pour l’Évangile, dès lors que celle-ci se révèle à lui comme le meilleur moyen pour trouver un équilibre entre sa foi et sa place dans la société de son époque. Car il ne fait guère de doute qu’au cours de sa trajectoire de chef huguenot, le prince de Porcien recherche et récolte une série de bienfaits, à commencer par un mariage contracté avec la fille d’un noble doté d’un rang nettement supérieur au sien et qui, de surcroît, devient héritière par la suite. Toutefois, loin de poursuivre une ascension uniquement pour assouvir des passions mondaines, Porcien estime que les situations favorables qui surgissent sur son chemin, et qui déclenchent ses ambitions, proviennent de Dieu. Or, ces situations favorables prédisposées par Dieu se manifestent durant son combat confessionnel. Ainsi s’expliquerait l’adhésion d’Antoine de Croÿ au calvinisme et au parti huguenot qui s’interrompt seulement avec son décès survenu en 1567.
Combattre les fantômes au tribunal : l’affaire Anne du Moulin (1572)
Authors: Callard Caroline
Published: October 2018

À partir du procès intenté à la suite de l’« horrible massacre », en janvier 1572 d’Anne du Moulin, de ses enfants et de leur nourrice à Paris rue des Augustins, cet article se propose d’examiner ce que pouvait être « l’action » des fantômes dans la justice d’Ancien Régime. En effet dans ce cas précis, et en l’absence de preuve tangible, l’avocat Barnabé Brisson proposa au tribunal de recevoir le témoignage du fantôme d’Anne Du Moulin, qui aurait dénoncé ses meurtriers à son mari. Ce cas exemplaire éclaire selon l’auteur le « moment spectral » de l’aube de la modernité, au cours duquel le fantôme est l’objet de saisies savantes, qui en assurent l’existence et lui permettent d’agir. En retour, il jette une lumière originale sur la grammaire spectrale du droit français au temps de son élaboration, au cœur duquel se situe l’adage polysémique : « le mort saisit le vif ».
Psychodynamique du travail et trauma
Authors: Buigues Chantal
Published: October 2018

Cet article veut rendre compte d’une pratique d’accueil et d’accompagnement de patients reçus dans une consultation « Souffrance et travail » abritée dans un service de Pathologie professionnelle et présentant une symptomatologie à caractère traumatique. La praxis psychanalytique freudienne constitue le socle d’une technique alliant une prise en charge fortement inspirée par Ferenczi, notamment au regard de sa notion de « témoin ». La psychodynamique du travail est convoquée comme un outil indispensable pour le thérapeute pour s’appuyer sur la centralité du travail dans la construction identitaire du sujet et comprendre l’atteinte psychique majeure qu’a engendrée un mode de management psychologiquement et symboliquement violent, identifié le plus souvent en termes de harcèlement moral. Cette technique thérapeutique résonne, semble-t-il, avec le point de vue soutenu par Christophe Dejours quand il propose que le harcèlement moral est une pathologie de l’isolement.
Pratiques artistiques et psychodynamique du travail
Authors: Debout Frédérique , Potiron Marie , Dussart Vincent , Joule Luc , Jousse Sébastien , Silhol Nicolas
Published: October 2018

Ce texte reprend les discussions de la table ronde « Pratiques artistiques et psychodynamique du travail » qui s’est tenue au neuvième Colloque international de psychodynamique et de psychopathologie du travail. Il est enrichi d’entretiens complémentaires avec chacun des participants. Depuis de nombreuses années, des discussions sont engagées entre des cliniciens-chercheurs travaillant à partir de la référence à la psychodynamique du travail et des artistes, à l’initiative des uns ou des autres. Des rencontres sont organisées dans des arènes scientifiques ou artistiques. On peut en effet considérer que certaines productions artistiques portant sur le monde du travail traitent de la subjectivité dans le travail et rendent compte d’une certaine démarche clinique. De plus, le travail des professionnels œuvrant dans les champs artistiques, l’engagement de la subjectivité des spectateurs sur lequel se fonde la portée de l’action artistique, représentent une voie possible de déplacement, voire de transformation, de l’imaginaire social. Consacrer un atelier aux pratiques artistiques dans un colloque de psychopathologie et de psychodynamique du travail nous semblait donc important parce que le travail des artistes et le travail en coopération avec ces derniers constituent des pratiques spécifiques et originales en psychodynamique du travail.
Apports de la psychodynamique du travail aux militants du Snupfen -Solidaires dans leurs pratiques syndicales à l’Office national des forêts
Authors: Dall’Armi Dominique , Pons Daniel , Tellechea Ramuntcho
Published: October 2018

Les auteurs de l’article discutent des nouvelles formes d’action qui ont pu émerger au sein de l’Office national des forêts en mobilisant les apports conceptuels et pratiques de la psychodynamique du travail. Ainsi décrivent-ils la manière dont le travail syndical, au sein de cette institution publique percutée, fissurée et altérée par les réformes gestionnaires dictées par l’idéologie du New Public Management, a été modifié par une réflexion nourrie par la clinique du travail. À la fin du texte, les auteurs soulignent les limites de l’action en pdt dans un contexte où se resserre l’étau néolibéral sur leur institution.
Psychodynamique du travail et action syndicale dans l’institution judiciaire une expérience de terrain
Authors: Milesi Ariane
Published: October 2018

Le présent article vise à rendre compte de l’apport de la psychodynamique du travail ( pdt ) à un groupe syndical désireux de comprendre les situations de souffrance au travail qui se développent dans l’institution judiciaire. À partir de son expérience de terrain, l’auteure tente de mettre en lumière la manière dont ce collectif a mobilisé les savoirs théoriques et pratiques en pdt dans son travail judiciaire et syndical. Dans cette perspective, l’auteure décrit plusieurs formes d’action collective qui se concrétisent sur le terrain et vient interroger les praticiens et chercheurs en Clinique du travail depuis son expérience de terrain.
Résistance et travail vivant : les apports de la psychodynamique du travail
Authors: Duarte Antoine
Published: October 2018

Fondée sur une enquête en psychodynamique du travail menée au sein d’une institution publique, l’article se propose de présenter ce qui peut s’apparenter à une action de résistance de certains salariés face aux contraintes du travail imposées par l’organisation néolibérale du travail. Par le truchement de cette investigation, une attention particulière est portée aux formes concrètes que revêtent les conduites de résistance inventées par les travailleurs de ce collectif confrontés aux dérives de certaines méthodes introduites dans leur entreprise depuis le tournant gestionnaire. In fine , la référence au travail vivant et aux savoirs en psychodynamique du travail permet de dégager une conception de la praxis de résistance visant spécifiquement à lutter contre trois des conséquences produites par l’organisation néolibérale du travail : le déni du travail vivant, la désolation et la banalisation de l’injustice sociale. Pour cela, le rôle revenant à la recomposition des coopérations dans le travail apparaît comme l’élément central structurant la praxis de résistance au néolibéralisme.
Défis professionnels et dynamique plaisir-souffrance dans le travail éducatif : une typologie des équipes
Authors: Kuehni Morgane , Bovey Laurent , Cerrone Toni , Richard Nicole
Published: October 2018

Basé sur des entretiens semi-directifs réalisés avec des éducateurs et éducatrices, cet article mobilise la notion de défi professionnel pour mettre en lumière le triple enjeu du travail réalisé auprès de personnes cumulant une déficience intellectuelle et des troubles psychiques dans les établissements socio-éducatifs. Il propose ensuite une typologie des équipes éducatives pour analyser les dynamiques de plaisir-souffrance au travail en axant plus particulièrement la réflexion sur l’autonomie des équipes et la perception des ressources disponibles. L’intérêt de la typologie réside moins dans les quatre types identifiés que dans les transitions des équipes entre les différents types selon leurs marges de manœuvre et les ressources à disposition pour faire un travail de qualité du point de vue des professionnel-le-s.
The Wire , une représentation attentive du travail. Les conflits déontiques et éthiques
Authors: Le Lay Stéphane
Published: October 2018

La saison 1 de The Wire permet d’analyser avec précision le rapport au métier de policier entretenu par différents protagonistes de la série. Ses auteurs insistent notamment sur les dimensions déontiques – relatives aux règles de métier – et éthiques logeant au cœur des pratiques, et sur les conflits qui peuvent y naître lors de certaines tensions institutionnelles. L’ensemble de ces éléments rend alors possible la compréhension de formes extrêmes d’« activisme professionnel », où l’isolement vécu par les policiers les plus engagés finit par saper le fondement éthique du travail d’enquêteur et les conditions mêmes de la confiance au travail.
The effect of rosemary extract on 3-MCPD and glycidyl esters during frying
Authors: Yıldırım A. , Yorulmaz A.
Published: October 2018

The aim of the present work was to evaluate the effect of rosemary extract (Rosmarinus Officinalis L.) on the 3-MCPD and glycidyl ester contents during deep-fat frying. Firstly, the potato samples were soaked in different concentrations of NaCl and they were fried in sunflower oils containing different concentrations of rosemary extract. Subsequently, repeated frying was carried out with sunflower oil enriched with rosemary extract. The frying oil and the oil extracted from potato samples were analyzed in terms of the contents of 3-MCPD and glycidyl esters according to DGF C VI 18 (10) method. The results demonstrated that the content of 3-MCPD and glycidyl esters in frying oil was not significantly affected by different NaCl and rosemary extract concentrations during short term frying; however, the amount of 3-MCPD esters was found to be lower for the potato crisps enriched with rosemary extract during repeated frying cycles.
Quality preservation of walnut kernels using edible coatings
Authors: Grosso A. L. , Asensio C. M. , Nepote V. , Grosso N. R.
Published: October 2018

The objective of this work was to evaluate the performance of various edible coatings for preserving the quality of walnut kernels (W) during storage. Three edible coatings based on carboxymethyl cellulose (CMC), methyl cellulose (MC) and whey protein isolates (WP) were prepared. Coated and uncoated walnuts (WC) were stored for 210 days at room temperature (23±2 °C). After 210 days, WC presented the highest peroxide value (PV = 3.06 meqO2/kg), conjugated dienes (CD = 3.01) and trienes (CT = 0.31), pentanal, nonanal, hexanal, and decane, 5,6-bis (2,2-dimethylpropylidene) contents. Meanwhile, WMC showed the lowest PV (1.20 meqO2/kg), CD (2.26) and CT (0.17) and the lowest decrease in carotenoid content (0.60 mg/kg). The L* value measured in walnut oil decreased in all samples. MC, CMC and WP coatings showed protection on walnuts against the deterioration process. MC coating displayed the best performance.
Variability of seed oil content, fatty acid composition, and nervonic acid content in Acer truncatum, native to 14 regions of China
Authors: Qiao Q. , Xue W. , Feng Z.
Published: October 2018

The seed oil of 138 accessions of 14 Acer truncatum (Aceraceae family) populations native to China were analyzed by pulsed nuclear magnetic resonance spectroscopy and gas chromatography-flame ionization detection. The oil content ranged from 17.81% to 36.56% (mean: 28.57%), which mainly consisted of 14 types of fatty acids. Palmitic (4.69%), stearic (2.30%), oleic (25.19%), linoleic (32.97%), linolenic (2.76%), cis-11-eicosenoic (7.90%), erucic (16.49%), and nervonic (5.76%) fatty acids accounted for 98% of total fat. The nervonic acid content ranged from 3.90% to 7.85% among the accessions. Significant variations in oil content and predominating fatty acids were observed among populations. Hierarchical cluster analysis and principal component analysis detected obvious geographical variation trends among A. truncatum populations which correlate with environmental variations (especially altitude, temperature, and precipitation) and supported the grouping of the populations into three groups according to geographic locations.
Distribución, hábitat y población reproductora del gorrión alpino (Montifringilla Nivalis) en el Pirineo Central (Aragón-España)
Authors: Gil Juan Antonio , Pérez Carlos
Published: October 2018

Con la ejecución del Atlas Ornitológico de Aragón tan solo se generó una primera aproximación de estatus, distribución, hábitat y abundancia de la población reproductora del gorrión alpino (Montifringilla nivalis) en el Pirineo Central (Aragón-España). En el presente artículo se ha revisado, actualizado y obtenido información sobre distribución, hábitat y población del gorrión alpino en Aragón. En total se obtienen 88 observaciones de la época de reproducción (mayo-agosto) entre 1986-2015. Los sectores de cría se sitúan a una media de 2.446 ± 310 m.s.n.m. El 38,6% de los registros se realizan en áreas con rocas básicas. Aumenta en un 43,4% la distribución, según la obtenida en el Atlas de Aragón 1998. Está presente en todos los macizos montañosos del Pirineo aragonés, a excepción de Turbón y Acherito, El área de ocupación con presencia comprobada es de 76 km2, en los que se localizaron un total de 262 parejas reproductoras y el área de ocupación potencial es de 658 km2, en la que se han estimado 1.823 parejas, con una densidad media de 2,77 pp./km2. Con la información obtenida de la especie en Aragón (3.646 individuos reproductores), el gorrión alpino debería ser objeto de una actualización de su distribución y población en los Pirineos (vertiente Sur) y España.
Hesperidin inhibits angiogenesis, induces apoptosis, and suppresses laryngeal cancer cell metastasis
Authors: Hana Randa , Bawi Bahaa
Published: October 2018

Introduction: Laryngeal carcinoma is the most common malignant head-and-neck tumor. Due to the low survival rate and the inadequate response to chemotherapy, effective therapy remains a challenge. Objectives: Therefore, the identification of new therapeutic options that preserve the larynx is needed. Hesperidin (Hsp) is a nontoxic plant flavanone that has proven effective against cancer. Materials and methods: Hence, the current in vivo and in vitro study was conducted to determine whether Hsp might suppress metastasis of cancer larynx. Results: In an in vivo mouse metastasis model, Hsp suppressed metastasis of human Hep2 laryngeal cancer cells to the livers and lungs. In vitro assays, Hsp significantly inhibited angiopoietin 1 secretion (an angiogenic promotor) and increased annexin-V (an apoptotic indicator) in Hep2 cell culture at relatively low levels (10 μM). Conclusions: These studies suggest that Hsp deserves further investigation as a possible treatment option for laryngeal cancer.
Knowledge, attitude, and practice of parents regarding Vitamin A supplementation to children in Benghazi, Libya
Authors: Abdulmalek Lubna , Benkhaial Fatma
Published: October 2018

Background: According to the World Health Organization, Vitamin A deficiency can cause immune system depression in about 130 million preschool children and 7 million pregnant women mostly in developing countries and cause mortality risk up to 20%–30%. Objectives: We aimed to evaluate the knowledge, attitude, and practice of parents in Benghazi regarding the Vitamin A campaign. Subjects and Methods: A cross-sectional descriptive study of 1390 parents attending maternal and child health clinics and pediatric clinics at six main polyclinics, in Benghazi in April and May 2018. Results: Most of the parents were younger than 40 years (71%). Mothers constitute 68% of the study population and 52% of the children were male. Half of the parents had higher education. Only 40% of the parents were having good knowledge about the benefits and food sources of Vitamin A. The coverage rate of Vitamin A supplementation among under-five children in the study was 66%. The main reason for not giving their children Vitamin A supplementation in this study was the lack of awareness of the campaign during the previous year. However, 88% of the interviewed parents had a positive attitude of regiving Vitamin A to their children in the next campaign. Conclusions: The overall knowledge level of Vitamin A among the parents was relatively low; hence, more efforts are needed to promote awareness about Vitamin A supplementation.
The rules and realities of authorship in biomedical journals: A cautionary tale for aspiring researchers
Authors: Beshyah Salem , Ibrahim Wanis , Aburawi Elhadi , Elkhammas Elmahdi
Published: October 2018

Medical research and publications are not only important for scientific development but also vital for the professional advancement and individual academic progress. Ranking is extremely important for appointments and leadership roles. Authorship is central to the credit and responsibility in medical research and appropriate assignment of authorship carries ethical, legal as well as intellectual implications. Despite being globally established for many years, deviation from the “International Committee of Medical Journal Editors (ICMJE)” criteria for authorship is still seen in varying orders of magnitude and in different shapes and forms. In this communication, we revisit the latest ICMJE criteria for authorship, highlight the increasingly recognized forms of potential of authorship misconduct (intentional or unintentional) and reflect on some emerging concepts and practices in authorship attribution. The target readers are primarily young and aspiring researchers who may err due to lack of experience but also veterans who may turn complacent for political reasons.
Safety and efficacy of weekly versus three-weekly paclitaxel plus platinum neoadjuvant chemotherapy in patients with locally advanced squamous cell head and neck carcinoma: A pilot study
Authors: Mathur Akash , Rastogi Naincy , Gurjar Dinesh , Sai Ramkrishna , Lakesar Arvind , Malhotra Hemant
Published: October 2018

Background: Squamous cell carcinoma of head and neck (SCCHN) is one of the most common cancers seen in India and also the world. Majority of patients present in locally advanced (LA) disease where neoadjuvant combination chemotherapy with a taxane plus platinum with/without 5-Fluorouracil is the standard of care treatment. There are no/few prospective trials of weekly paclitaxel in SCCHN in spite of convincing evidence regarding safety and tolerability in other solid tumors such as breast, ovary, and lung carcinoma. In the present study, we prospectively assessed the safety and efficacy of weekly versus three-weekly paclitaxel plus platinum neoadjuvant chemotherapy in patients with LA-SCCHN. Materials and Methods: We included 50 newly diagnosed patients of LA-SCCHN in the study and randomized them into two groups to receive either low-dose weekly (80 mg/sq. m) or standard three-weekly (175 mg/sq. m) paclitaxel along with standard dose carboplatin (AUC 5) and assessed response rates and toxicities. Results: Age and sex were evenly matched in both groups. Oral and oropharyngeal cancers were the most common sites. Hematological toxicities were significantly more in the three-weekly group. Nonhematological toxicities, especially neuropathy, were also more in this group. The overall response rate (complete response + partial response) in the three-weekly arm was 36% versus 52% in the weekly arm. Conclusion: Data from our small study suggest that weekly paclitaxel plus platinum neoadjuvant chemotherapy may be superior to the standard every 3 weeks' administration in terms of safety as well as efficacy in patients with LA-SCCHN.
Retrospective study of oxaliplatin, leucovarin and 5 fluoruracil regimen in patients with advanced gastric cancer with poor performance status: A study at a tertiary center of South India
Authors: Guruprasad Bhat
Published: October 2018

Background: Gastric carcinoma is the leading cause of cancer in south India. Gastric cancer is frequently diagnosed in locally advanced or metastatic setting in Indian scenario and has a poor survival. There is no standard chemotherapy regimen which can be used in advanced gastric cancer (AGC) patients. Objective: The aim of this study was to assess the clinical activity and toxicity of oxaliplatin with infusional 5-fluorouracil and leucovorin administered every 3 weeks in patients with locally advanced and inoperable gastric cancer. Patients and Methods: In this retrospective study, the case records of 25 patients who have received OLF regimen were analyzed. Results: The median number of cycles for patients was 6 (range: 4–12 cycles). Overall response rate was 36%, with all patients having stable disease. Median survival of patients was 6 months (7 months in locally advanced). Compared to other regimens, there was less toxicity (less hematologic toxicity, less nausea and vomiting, no hair loss, no renal toxicity, no hand foot syndrome, and lesser admissions). Conclusions: OLF regimen is an acceptable regimen in poor performance status AGC patients with adequate response and an acceptable toxicity profile.
Quality of life and quality-adjusted time without toxicity in palliatively treated head-and-neck cancer patients
Authors: Patil Vijay , Joshi Amit , Noronha Vanita , Bhattacharjee Atanu , Dhumal Sachin , Chandrakanth M. V. , Karpe Ashay , Talreja Vikas , Chandrasekharan Arun , Turkar Siddharth , Pande Nikhil , Ramaswamy Anant , Prabhash Kumar
Published: October 2018

Background: Quality-adjusted time without toxicity (Q-TWiST) and quality of life (QOL) are indicators of benefit provided by different chemotherapy regimens. Methods: This was a prospective study, in which adult head-and-neck (H and N) cancer patients, treated with metronomic chemotherapy were enrolled. The Functional Assessment of Cancer Therapy-General H and N (FACT-G and H and N) version 4 pro formas were self-administered before the start of chemotherapy and then at 2, 4, and 6 months. FACT QOL and Q-TWiST analysis were then performed. Results: There was an improvement in the social well-being (P = 0.370), emotional well-being (P = 0.000), functional well-being (P = 0.000), H and N cancer subscale (P = 0.001), FACT H and N trial outcome index (P = 0.000), FACT G-total score (P = 0.000), and FACT H and N total score (P = 0.000) with palliative chemotherapy. The QTWiST value for a utility score of 0.25 for toxicity and relapse state was 145.93 days. Conclusion: Metronomic chemotherapy is associated with improvement in QOL and has a low duration of time spent in toxicity state.
Comparative analysis of the Sokal, Euro and European Treatment and Outcome Study score in prognostication of Indian chronic myeloid leukemia-chronic phase patients on imatinib
Authors: Chhikara Sunita , Sazawal Sudha , Singh Kanwaljeet , Chaubey Rekha , Pati Haraprasad , Tyagi Seema , Mahapatra Manoranjan , Saxena Renu
Published: October 2018

Introduction: The ultimate goal for CML management is risk stratification of the patients to design the appropriate treatment approach. The Sokal, Euro and EUTOS risk scores were established to prognosticate the patients on therapy. Aim: To perform a comparative assessment of the Sokal, Euro and EUTOS prognostic score in Indian CML-CP patients on imatinib. Methods: This is a retrospective study performed in 260 Ph+ CML-CP patients who were administered oral imatinib (400 mg/day). Results: 166/260 were males and 94/260 were females (M: F::1.6:1) with median age 35 years (range 20-70). 92 (35.38%), 125 (48.07%) and 43 (16.5%) patients were divided into low, intermediate and high risk Sokal score respectively. 102 (39.23%), 106 (40.76%) and 52 (20%) patients were discriminated into low, intermediate and high risk Euro score respectively. 210 (80.7%) and 50 (19.2%) patients were divided into low and high risk EUTOS score. Cumulative incidence of MMR for low, intermediate and high-risk Sokal score was 87%, 76% and 84% respectively (P = 0.016). Incidence of MMR in low, intermediate and high-risk Euro score was 93%, 85% and 68% respectively (P = 0.001). Incidence of MMR was 80 % and 81% for low and high risk EUTOS score (P = 0.764). Both EFS and OS are significantly correlated with Sokal score (P = 0.004, P = 0.007) and Euro score (P = 0.009, P = 0.001) but not with EUTOS score (P = 0.581, P = 0.927). Conclusion: The present study highlights the significant prognostic role of Sokal and Euro score in predicting the treatment outcome of the CML- CP patients on imatinib.
Clinicopathological features, treatment and survival outcomes of synovial sarcoma
Authors: Kuruva Siva Prasad , Bala Stalin , Konatam Meher Lakshmi , Karnam Ashok Kumar , Maddali Lakshmi Srinivas , Gundeti Sadashuivudu
Published: October 2018

Introduction: Synovial sarcoma (SS) is a malignant mesenchymal tumor. It is most common among children and adults. The data on SS from India are scarce. In this study, we analyzed the clinicopathological treatment parameters and survival outcomes of SS patients. Materials and Methods: A total of 57 histologically proven SS diagnosed from 2010 to 2016 were retrospectively analyzed. Results: The median age was 23 years with a male-to-female ratio of 1.28:1. Localized disease was seen in 44 patients (77%) and 13 patients (23%) had metastasis. The primary sites of involvement such as lower limb, upper limb, thorax, and abdomen were seen in 60%, 28%, 7%, and 5% patients, respectively. Surgery was done in 39 patients and 18 patients had unresectable disease. Adjuvant chemotherapy with doxorubicin-based regimen was given in 30 patients and adjuvant radiotherapy in 21 patients. Palliative chemotherapy with anthracycline-based or gemcitabine-based regimen was used in 17 and 2 patients, respectively. The median event-free survival (EFS) was 30 months with 3 years and EFS rate was 36%; median progression-free survival (PFS) was 11.5 months and 1 year; and PFS rate was 38%. On univariate analysis, resection and performance status were significantly associated with survival. There is no impact of grade and size of the tumor on survival. In metastatic patients, the lung is the most common site. Conclusion: SS is the most common soft-tissue sarcoma among adults. Resectability and performance status were impacting the survival.
Brexit and state aid control: four quartets
Authors: Biondi Andrea
Published: October 2018

The United Kingdom Government has recently given its clearest indication yet that a domestic state aid regulatory regime, would have to be in place at the end of the Brexit process. The Competition and Markets Authority has been designated as the domestic state aid regulator. This article reassesses the importance of the provisions on state aid within the European Union legal order and reviews the control of subsidies in international trade law, both under World Trade Organization rules and in the EU's trade agreements with third countries. It further examines the challenges and opportunities presented by a process of decentralization of state aid control in the United Kingdom in the context of the negotiations for a future EU-UK trade agreement.
Data assimilation cycle length and observation impact in mesoscale ocean forecasting
Authors: Sandery Paul
Published: October 2018

Abstract. A brief examination of the relationship
between data assimilation cycle length and observation impact in a practical
global mesoscale ocean forecasting setting is provided. Behind-real-time
reanalyses and forecasts from two different cycle length systems are compared
and skill is quantified using all observations typically available for ocean
forecasting. A 1-day Ensemble Optimal Interpolation (EnOI) cycle is compared
to a 3-day cycle. The mean analysis increments for the 1-day system are
significantly smaller, suggesting a less biased system. Comparison of mean
absolute increments identifies observations have greater impact in the 1-day
system. Whilst smaller mean increments and greater observation impact do not
guarantee a better forecast system, analysis of 7-day parallel forecasts show
that the 1-day cycle system delivers improvement in predictability,
particularly for the subsurface. This improvement appears to mainly come from
less biased initial conditions and suggests greater retention of memory from
observations and improved balance in the model.
Implementation of a comprehensive ice crystal formation parameterization for cirrus and mixed-phase clouds in the EMAC model (based on MESSy 2.53)
Authors: Bacer Sara , Sullivan Sylvia C. , Karydis Vlassis A. , Barahona Donifan , Krämer Martina , Nenes Athanasios , Tost Holger , Tsimpidi Alexandra P. , Lelieveld Jos , Pozzer Andrea
Published: October 2018

Abstract. A comprehensive ice nucleation parameterization has been
implemented in the global chemistry-climate model EMAC to improve the
representation of ice crystal number concentrations (ICNCs). The
parameterization of Barahona and Nenes (2009, hereafter BN09) allows for the
treatment of ice nucleation taking into account the competition for water
vapour between homogeneous and heterogeneous nucleation in cirrus clouds.
Furthermore, the influence of chemically heterogeneous, polydisperse aerosols
is considered by applying one of the multiple ice nucleating particle
parameterizations which are included in BN09 to compute the heterogeneously
formed ice crystals. BN09 has been modified in order to consider the
pre-existing ice crystal effect and implemented to operate both in the cirrus
and in the mixed-phase regimes. Compared to the standard EMAC
parameterizations, BN09 produces fewer ice crystals in the upper troposphere
but higher ICNCs in the middle troposphere, especially in the Northern
Hemisphere where ice nucleating mineral dust particles are relatively
abundant. Overall, ICNCs agree well with the observations, especially in cold
cirrus clouds (at temperatures below 205 K), although they are
underestimated between 200 and 220 K. As BN09 takes into account
processes which were previously neglected by the standard version of the
model, it is recommended for future EMAC simulations.
Design water demand of irrigation for a large region using a high-dimensional Gaussian copula
Authors: Tu Xinjun , Du Yiliang , Singh Vijay P. , Chen Xiaohong , Lin Kairong , Wu Haiou
Published: October 2018

Abstract. Spatial and frequency distributions of precipitation should be considered in
determining design water demand of irrigation for a large region. In
Guangdong Province, South China, as a study case, an eight-dimensional joint
distribution of precipitation for agricultural sub-regions was developed. A
design procedure for water demand of irrigation for a given frequency of
precipitation of the entire region was proposed. Water demands of irrigation
in the entire region and its sub-regions using three design methods, i.e.,
equalized frequency (EF), typical year (TY) and most-likely weight function
(MLW), were compared. Results demonstrated that the Gaussian copula
efficiently fitted the high-dimensional joint distribution of eight
sub-regional precipitation values. The Kendall frequency was better than the
conventional joint frequency to analyze the linkage between the frequency of
precipitation of the entire region and individual sub-regions. For given
frequencies of precipitation of the entire region, design water demands of
irrigation of the entire region among the MLW, EF and TY methods slightly
differed, but those of individual sub-regions of the MLW and TY methods
fluctuated around the demand lines of the EF method. The alterations of
design water demand in sub-regions were more complicated than those in the
entire region. The design procedure using the MLW method in association with
a high-dimensional copula, which simulated individual univariate
distributions, captured their dependences for multi-variables, and built a
linkage between regional frequency and sub-regional frequency of
precipitation, is recommended for design water demand of irrigation for a
large region.
Breeze effects at a large artificial lake: summer case study
Authors: Iakunin Maksim , Salgado Rui , Potes Miguel
Published: October 2018

Abstract. Natural lakes and big artificial reservoirs can affect the weather regime of
surrounding areas but, usually, consideration of all aspects of this impact
and their quantification is a difficult task. The Alqueva reservoir, the largest
artificial lake in western Europe, located on the south-east of Portugal, was
filled in 2004. It is a large natural laboratory that allows the study of
changes in surface and in landscape and how they affect the weather in the
region. This paper is focused on a 3-day case study, 22–24 July 2014, during
which an intensive observation campaign was carried out. In order to quantify
the breeze effects induced by the Alqueva reservoir, two simulations with the
mesoscale atmospheric model Meso-NH coupled to the FLake freshwater lake model
has been performed. The difference between the two simulations lies in the
presence or absence of the reservoir on the model surface. Comparing the two
simulation datasets, with and without the reservoir, net results of the lake
impact were obtained. Magnitude of the impact on air temperature, relative
humidity, and other atmospheric variables are shown. The clear effect of a lake
breeze (5–7 m s−1) can be observed during daytime on distances up to
6 km away from the shores and up to 300 m above the surface. The lake breeze
system starts to form at 09:00 UTC and dissipates at 18:00–19:00 UTC with
the arrival of a larger-scale Atlantic breeze. The descending branch of the
lake breeze circulation brings dry air from higher atmospheric layers
(2–2.5 km) and redistributes it over the lake. It is also shown that
despite its significant intensity the effect is limited to a couple of
kilometres away from the lake borders.
La respuesta comunicativa de las ONGD andaluzas con la campaña ’20 años del 0,7’ en el contexto de crisis de la cooperación internacional
Authors: Toro Peña Óscar , Contreras Pulido Paloma , Hernando Gómez Ángel
Published: October 2018

El artículo analiza la respuesta comunicativa de la Coordinadora Andaluza de ONGD (CAONGD) con la campaña conmemorativa ’20 años del 0,7’ en el contexto de crisis de la cooperación internacional al desarrollo (2008-2015). Los resultados, tras la entrevista a responsables de la campaña y la celebración de un grupo de discusión, evidencian tres escenarios: el primero, el fracaso inicial de una estrategia convencional centrada en denunciar los efectos de los recortes en cooperación que no conectan con la ciudadanía; el segundo, tras un giro estratégico, apelando a la memoria colectiva y al recuerdo de las acampadas estatales que reivindicaron que se destinase el 0,7% del PIB a la cooperación al desarrollo; y el tercero, demostrando que el espacio comunicativo natural de las entidades es el que se articula desde los planteamientos de la comunicación para el cambio social.
Condiciones y rendimientos de la Investigación en Comunicación: la visión de los académicos
Authors: Gaitán Juan Antonio , Caffarel Carmen , Lozano Carlos , Piñuel José Luis
Published: October 2018

El Proyecto MapCom (www.mapcom.es) lanzó en 2017 una encuesta destinada al universo de investigadores en Comunicación censados como doctores en nómina en los centros universitarios españoles con grados y postgrados en las carreras de Comunicación, en sociedades científicas y en programas de doctorado, solicitándoles vía internet cumplimentar un formulario centrado en su experiencia investigadora. En este artículo se ofrecen los datos sobre las condiciones y rendimientos de su actividad Investigadora y de su estatus como investigador, obtenidos en aquella encuesta. Se preguntó sobre cuál era su valoración sobre las condiciones materiales (financiación, becas y contratos, burocracia, instalaciones), organizacionales (requisitos de las convocatorias, formación metodológica, redes científicas, capital humano) e institucionales (compatibilidad con la docencia, relación Universidad/ empresa, Agencias de Evaluación, Congresos, Revistas). De estos datos se desprende la tendencia a valorar negativamente las condiciones materiales, mientras que las condiciones organizacionales e institucionales recibieron valoraciones positivas y negativas diversas según los ítems. Los rendimientos recibieron valoraciones más positivas cuando se relacionaban con el corporativismo académico que cuando se vinculaban a la competencia científica.
La política da que hablar: "Engagement" en redes sociales de sitios de noticias
Authors: Mitchelstein Eugenia , Leiva Silvana , Giuliano Camilia , Boczkowski Pablo J.
Published: October 2018

Este trabajo examina la relación entre los contenidos presentados en las cuentas oficiales de Facebook y Twitter de ocho sitios de noticias de Argentina y el nivel de engagement que generaron en los usuarios. El análisis de una muestra de 2.039 noticias, publicadas entre los meses de marzo a noviembre de 2017, muestra que existe una relación entre el contenido de las noticias y el nivel de engagement que las mismas generan entre los usuarios. Si bien los sitios presentaron una mayor cantidad de noticias sobre temáticas de asuntos no públicos, como deportes, policiales o entretenimiento, los mayores niveles de engagement se registraron en noticias sobre asuntos públicos, como política nacional e internacional y economía. Estos hallazgos son consistentes con la literatura sobre proceso de adaptación de los medios al nuevo ecosistema mediático y apoyan la teoría de “ciudadanía monitorial” en el contexto digital.
Tissue or blood: which is more suitable for detection of EGFR mutations in non-small cell lung cancer?
Authors: Biaoxue Rong , Shuanying Yang
Published: October 2018

Background:

Many studies have evaluated the accuracy of EGFR mutation status in blood against that in tumor tissues as the reference. We conducted this systematic review and meta-analysis to assess whether blood can be used as a substitute for tumor tissue in detecting EGFR mutations.

Methods:

Investigations that provided data on EGFR mutation status in blood were searched in the databases of Medline, Embase, Ovid Technologies and Web of Science. The detect efficiency of EGFR mutations in paired blood and tissues was compared using a random-effects model of meta-analysis. Pooled sensitivity and specificity and diagnostic accuracy were calculated by receiver operating characteristic curve.

Results:

A total of 19 studies with 2,922 individuals were involved in this meta-analysis. The pooled results showed the positive detection rate of EGFR mutations in lung cancer tissues was remarkably higher than that of paired blood samples (odds ratio [OR] = 1.47, p<0.001). The pooled sensitivity and specificity of blood were 0.65 and 0.91, respectively, and the area under the receiver operating characteristic curve was 0.89.

Conclusions:

Although blood had a better specificity for detecting EGFR mutations, the absence of blood positivity should not necessarily be construed as confirmed negativity. Patients with negative results for blood should decidedly undergo further biopsies to ascertain EGFR mutations.
Significance of Platelet and AFP Levels and Liver Function Parameters for HCC Size and Survival
Authors: Carr Brian I. , Guerra Vito , Giannini Edoardo G. , Farinati Fabio , Ciccarese Francesca , Rapaccini Gian Ludovico , Di Marco Maria , Benvegnù Luisa , Zoli Marco , Borzio Franco , Caturelli Eugenio , Chiaramonte Maria , Trevisani Franco ,   for the Italian Liver Cancer (ITA.LI.CA) group*
Published: October 2018

Background

Hepatocellular carcinoma (HCC) is a heterogeneous disease with both tumor and liver factors being involved.

Aims

To investigate HCC clinical phenotypes and factors related to HCC size.

Methods

Prospectively-collected HCC patients' data from a large Italian database were arranged according to the maximum tumor diameter (MTD) and divided into tumor size terciles, which were then compared in terms of several common clinical parameters and patients' survival.

Results

An higer MTD tercile was significantly associated with increased blood alpha-fetoprotein (AFP), gamma-glutamyl transpeptidase (GGTP), and platelet levels. Patients with higher platelet levels had larger tumors and higher GGTP levels, with lower bilirubin levels. However, patients with the highest AFP levels had larger tumors and higher bilirubin levels, reflecting an aggressive biology. AFP correlation analysis revealed the existence of 2 different groups of patients: those with higher and with lower AFP levels, each with different patient and tumor characteristics. The Cox proportional-hazard model showed that a higher risk of death was correlated with GGTP and bilirubin levels, tumor size and number, and portal vein thrombosis (PVT), but not with AFP or platelet levels.

Conclusions

An increased tumor size was associated with increased blood platelet counts, AFP and GGTP levels. Platelet and AFP levels were important indicators of tumor size, but not of survival.
Doctorado en Estudios Interculturales: un análisis de pertinencia y factibilidad para el Modelo de Universidad Comunitaria Intercultural
Authors: Flores López William Oswaldo , Castillo Gómez Letisia
Published: October 2018

Esta investigación ha analizado la pertinencia y factibilidad de un programa de doctorado en estudios interculturales en la Universidad Comunitaria Intercultural, de la Universidad de las Regiones Autónomas de la Costa Caribe Nicaragüense (URACCAN). Se aplicaron métodos y técnicas de los paradigmas cualitativo y cuantitativo, sustentados en un diseño descriptivo, los datos fueron resultado de una entrevista semi-estructurada a hombres y mujeres de la URACCAN y a futuros empleadores de investigadores con el nivel de doctorado; además, se revisó documentación de políticas, normativas, artículos científicos y publicaciones en diarios de comunicación digital. El análisis se desarrolló utilizando el paquete estadístico para las Ciencias Sociales y una matriz de categorización. Los principales resultados reflejaron que existe demanda de formación de talentos humanos en el grado de doctorado para alcanzar los niveles de competitividad en investigación, desarrollo e innovación; así como una demanda por parte de profesionales con grado de maestría por realizar estudios doctorales. Asimismo, se cuenta con recursos físicos, financieros y humanos para desarrollar el programa de doctorado. Todo lo anterior, nos permite avalar la necesidad de formar doctores en estudios interculturales que respondan a las necesidades y aspiraciones de los pueblos de la Costa Caribe y Ab’ya Yala.
Chile y sus museos comunitarios: reservas identitarias en escenarios de interculturalidad
Authors: Adasme Calisto Estela , Quinteros Flores Christian
Published: October 2018

En este artículo se han analizado los museos comunitarios de Chile, el aporte a la sustentabilidad social y a la identidad local de los territorios que representan estos espacios de conservación y exposición de artefactos tanto materiales como inmateriales, en escenarios de creciente interculturalidad. Se ha revisado el concepto de museo comunitario, distinguiéndolo conceptualmente de otros tipos de iniciativas similares, desde un enfoque de sustentabilidad. El estudio se ha realizado a partir del análisis descriptivo a nivel documental de siete casos de museos comunitarios registrados en la base de datos de la Dirección de Bibliotecas Archivos y Museos de Chile (DIBAM) donde se abordaron la totalidad existente, complementada esta información con dos experiencias de terreno. Esta investigación ha permitido conocer los aportes de este tipo de expresión cultural al reconocimiento de las identidades locales, lo que permite conservar el repertorio cultural de las comunidades donde se han insertado como sistemas de reproducción identitaria.
Antropología e innovación: Desarrollo comunitario desde la innovación culturalmente situada
Authors: Solis Narváez Norling
Published: October 2018

La antropología ha constituido un campo relativamente longevo en nuestro continente; sin embargo, para Nicaragua es una ciencia reciente que ha avanzado sutilmente en las comunidades a través del acompañamiento desde el desarrollo comunitario. Las transformaciones socioeconómicas de Nicaragua, exigen re-estructuraciones económicas, sociales y culturales internas a las comunidades. Actualmente el campo de la innovación se ha vuelto un referente en la primera etapa de la juventud, en las comunidades, los barrios, los municipios, se fomentan las economías a través de innovaciones y por supuesto de emprendimientos, tanto de las instituciones públicas y privadas; empero, debemos hacer la pausa y preguntar ¿Son las innovaciones pertinentes culturalmente?, quizás sí, o quizás existen innovaciones que a través de los llamados influenciadores “influencers” llegan al público. En este ensayo se ha la reflexionado a la importancia de la etnografía aplicada a procesos de innovación en las comunidades, enfocados a fortalecer las capacidades locales, en función del reconocimiento de la cultura y necesidades focalizadas.
Luz através de coberturas coloridas transparentes sobre Corynespora cassiicola  causador da mancha-alvo no tomateiro
Authors: Paixão Anna Carla de Castro , Macedo Galileo Lopes , Coelho Netto Roselee A.
Published: October 2018

Luz através de coberturas coloridas transparentes sobre Corynespora cassiicola  causador da mancha-alvo no tomateiro 
Opioid Prescribing Practices of Orthopaedic Surgeons: Results of a National Survey
Authors: Raneses Eli , Secrist Eric S. , Freedman Kevin B. , Sohn David H. , Fleeter Thomas B. , Aland Christopher M.
Published: October 2018

Introduction:

Opioids are widely used after orthopaedic procedures. Nonmedical opioid use is a growing public health issue.

Methods:

An anonymous online survey was distributed by e-mail to the orthopaedic societies of all 50 states and several large private practices to assess practicing orthopaedic surgeons' opioid prescribing practices.

Results:

A total of 555 orthopaedic surgeons practicing in 37 states responded. The most commonly prescribed opioid for both teenagers and adults was hydrocodone/acetaminophen. Of note, 42.3% reported that a patient they have prescribed opioids for developed an opioid dependency, whereas 35.3% do not believe that opioid use is a problem in their practice. Of note, 30.3% reported prescribing refills, and factors significantly associated with increased prescribing of refills included a greater number of years in practice (P < 0.001) and practicing in a suburban rather than an urban or rural environment (P = 0.03).

Conclusion:

Orthopaedic surgeons rarely prescribe any refills, tend to prescribe less opioids to teenagers than adults, and prescribe fairly uniformly for patients who are treated nonsurgically or undergo minor or arthroscopic surgery. They exhibit considerable variation in prescribing for fractures and major procedures.