bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from Increased cyclin D1 expression can mediate BRAF inhibitor resistance in BRAF V600E–mutated melanomas
Authors: Smalley Keiran S.M. , Lioni Mercedes , Palma Maurizia Dalla , Xiao Min , Desai Brijal , Egyhazi Suzanne , Hansson Johan , Wu Hong , King Alastair J. , Van Belle Patricia , Elder David E. , Flaherty Keith T. , Herlyn Meenhard , Nathanson Katherine L.
Published: April 2023

Abstract
Recent studies have shown that there is a considerable heterogeneity in the response of melanoma cell lines to MEK and BRAF inhibitors. In the current study, we address whether dysregulation of cyclin-dependent kinase 4 (CDK4) and/or cyclin D1 contribute to the BRAF inhibitor resistance of melanoma cells. Mutational screening identified a panel of melanoma cell lines that harbored both a BRAF V600E mutation and a CDK4 mutation: K22Q (1205Lu), R24C (WM39, WM46, and SK-Mel-28), and R24L (WM902B). Pharmacologic studies showed that the presence of a CDK4 mutation did not alter the sensitivity of these cell lines to the BRAF inhibitor. The only cell line with significant BRAF inhibitor resistance was found to harbor both a CDK4 mutation and a CCND1 amplification. Array comparative genomic hybridization analysis showed that CCND1 was amplified in 17% of BRAF V600E–mutated human metastatic melanoma samples, indicating the clinical relevance of this finding. As the levels of CCND1 amplification in cell lines are lower than those seen in clinical specimens, we overexpressed cyclin D1 alone and in the presence of CDK4 in a drug-sensitive melanoma line. Cyclin D1 overexpression alone increased resistance and this was enhanced when cyclin D1 and CDK4 were concurrently overexpressed. In conclusion, increased levels of cyclin D1, resulting from genomic amplification, may contribute to the BRAF inhibitor resistance of BRAF V600E–mutated melanomas, particularly when found in the context of a CDK4 mutation/overexpression. [Mol Cancer Ther 2008;7(9):2876–83]
Data from A coordinated action of Bax, PUMA, and p53 promotes MG132-induced mitochondria activation and apoptosis in colon cancer cells
Authors: Ding Wen-Xing , Ni Hong-Min , Chen Xiaoyun , Yu Jian , Zhang Lin , Yin Xiao-Ming
Published: April 2023

Abstract
Targeting the ubiquitin-proteasome degradation pathway has become a promising approach for cancer therapy. Previous studies have shown that proteasome inhibition leads to apoptosis in various cancer cells. The mechanism by which apoptosis occurs are not fully understood and can be cell type and/or inhibitor specific. In this study, we investigated the mechanism of mitochondrial activation by proteasome inhibitors in colon cancer cells. We found that Bax activation and mitochondria translocation were required for apoptosis induced by multiple proteasome inhibitors. In contrast, reactive oxygen species did not seem to be induced by MG132 or bortezomib and antioxidants had no effects on MG132-induced apoptosis. In contrast, treatment with MG132 or bortezomib induced a significant accumulation of p53 and PUMA. Genetic deletion of either p53 or PUMA led to a marked suppression of apoptosis induced by these inhibitors, accompanied with reduced Bax activation and cytochrome c release. Consistently, inhibition of translation by cycloheximide could also effectively abolish the accumulation of p53 and PUMA and suppress MG132-induced Bax activation and apoptosis. These findings thus strongly indicate the critical involvement of p53-, PUMA-, and Bax-mediated mitochondrial activation in proteasome inhibitor–induced apoptosis in colon cancer cells. [Mol Cancer Ther 2007;6(3):1062–9]
Data from The Antitumor Activity of Homoharringtonine against Human Mast Cells Harboring the KIT D816V Mutation
Authors: Jin Yanli , Lu Zhongzheng , Cao Kaiyuan , Zhu Yunhui , Chen Qi , Zhu Feng , Qian Chenchen , Pan Jingxuan
Published: April 2023

Abstract
Gain-of-function mutations of the receptor tyrosine kinase KIT play a critical role in the pathogenesis of systemic mastocytosis (SM) and gastrointestinal stromal tumors. The various juxtamembrane type of KIT mutations, including V560G, are found in 60% to 70% of patients with gastrointestinal stromal tumors; loop mutant D816V, which exists in ∼80% of SM patients, is completely resistant to imatinib. In the present study, we hypothesized that homoharringtonine (HHT), a protein synthesis inhibitor, would decrease the level of KIT protein by inhibiting translation, resulting in a decreased level of phospho-KIT and abrogating its constitutive downstream signaling. Imatinib-sensitive HMC-1.1 cells harboring the mutation V560G in the juxtamembrane domain of KIT, imatinib-resistant HMC-1.2 cells harboring both V560G and D816V mutations, and murine P815 cells were treated with HHT and analyzed in terms of growth, apoptosis, and signal transduction. The in vivo antitumor activity was evaluated by using the murine mast cell leukemia model. Our results indicated that HHT effectively inhibited the growth and induced apoptosis in cells bearing both V560G and D816V or D814Y KIT. Additionally, HHT inhibited the KIT-dependent phosphorylation of downstream signaling molecules Akt, signal transducer and activator of transcription 3 and 5, and extracellular signal-regulated kinase 1/2. Furthermore, HHT significantly prolonged the survival duration of mice with aggressive SM or mast cell leukemia by inhibiting the expansion and infiltration of imatinib-resistant mast tumor cells harboring imatinib-resistant D814Y KIT. Collectively, we show that HHT circumvents D816V KIT-elicited imatinib resistance. Our findings warrant a clinical trial of HHT in patients with SM harboring D816V or D814Y KIT. Mol Cancer Ther; 9(1); 211–23
Data from Expression of ABCG2 (BCRP) Is Regulated by Nrf2 in Cancer Cells That Confers Side Population and Chemoresistance Phenotype
Authors: Singh Anju , Wu Hailong , Zhang Ping , Happel Christine , Ma Jinfang , Biswal Shyam
Published: April 2023

Abstract
ATP-binding cassette, subfamily G, member 2 (ABCG2) is expressed in both normal and cancer cells and plays a crucial role in side population (SP) formation and efflux of xenobiotics and drugs. Nrf2, a redox-sensing transcription factor, on constitutive activation in non–small-cell lung cancer cells upregulates a wide spectrum of genes involved in redox balance, glutathione metabolism, and drug detoxification, which contribute to chemoresistance and tumorigenicity. This study examined the mechanism underlying Nrf2-dependent expression of ABCG2 and its role in the multidrug resistance phenotype. In silico analysis of the 5′-promoter flanking region of ABCG2 identified an antioxidant response element (ARE) at −431 to −420 bp. A detailed promoter analysis using luciferase reporter assays showed that ARE at −431 to −420 bp is critical for the Nrf2-mediated expression in lung cancer cells. Electrophoretic mobility shift assays and chromatin immunoprecipitation assays revealed that Nrf2 interacts with the ABCG2 ARE element at −431 to −420 bp in vitro and in vivo. Disruption of Nrf2 expression in lung and prostate cancer cells, by short hairpin RNA, attenuated the expression of ABCG2 transcript and protein, and dramatically reduced the SP fraction in Nrf2-depleted cancer cells. Moreover, depleted levels of ABCG2 in these Nrf2 knockdown cells sensitized them to mitoxantrone and topotecan, two chemotherapy drugs detoxified mainly by ABCG2. As expected, overexpression of Nrf2 cDNA in lung epithelial cells led to an increase in ABCG2 expression and a 2-fold higher SP fraction. Thus, Nrf2-mediated regulation of ABCG2 expression maintains the SP fraction and confers chemoresistance. Mol Cancer Ther; 9(8); 2365–76. ©2010 AACR.
Data from Integrin-targeted imaging and therapy with RGD4C-TNF fusion protein
Authors: Wang Hui , Chen Kai , Cai Weibo , Li Zibo , He Lina , Kashefi Amir , Chen Xiaoyuan
Published: April 2023

Abstract
This study used integrin αvβ3 as a target for tumor-specific delivery of tumor necrosis factor-α (TNF). The fusion protein RGD4C-TNF bound specifically to αvβ3 as evidenced by cell receptor binding assay and noninvasive micro-positron emission tomography imaging. 64Cu-DOTA-RGD4C-TNF had significantly higher activity accumulation in integrin-positive tumors (U87MG and MDA-MB-435) but not in integrin-negative tumors (C6) compared with 64Cu-DOTA-TNF. The magnitude of tumor uptake of 64Cu-DOTA-RGD4C-TNF correlated well with the αvβ3 level (U87MG > MDA-MB-435 > C6). Tumor accumulation of 64Cu-DOTA-RGD4C-TNF could be effectively blocked by c(RGDyK) peptide in αvβ3-positive tumor models, suggesting αvβ3 specificity of RGD4C-TNF fusion protein in vivo. Furthermore, although the fusion of RGD4C moiety to TNF had little effect on the bioactivity and cytotoxicity of RGD4C-TNF compared with TNF in cell culture, RGD4C-TNF was significantly more potent than TNF in inhibiting orthotopic MDA-MB-435 tumor growth. Ex vivo tissue staining confirmed specific cytotoxicity of RGD4C-TNF against integrin-positive tumor cells and tumor vasculature. [Mol Cancer Ther 2008;7(5):1044–53]
Data from Combinatorial efficacy of anti-CS1 monoclonal antibody elotuzumab (HuLuc63) and bortezomib against multiple myeloma
Authors: van Rhee Frits , Szmania Susann M. , Dillon Myles , van Abbema Anne M. , Li Xin , Stone Mary K. , Garg Tarun K. , Shi JuMei , Moreno-Bost Amberly M. , Yun Rui , Balasa Balaji , Ganguly Bishwa , Chao Debra , Rice Audie G. , Zhan Fenghuang , Shaughnessy John D. , Barlogie Bart , Yaccoby Shmuel , Afar Daniel E.H.
Published: April 2023

Abstract
Monoclonal antibody (mAb) therapy for multiple myeloma, a malignancy of plasma cells, has not been clinically efficacious in part due to a lack of appropriate targets. We recently reported that the cell surface glycoprotein CS1 (CD2 subset 1, CRACC, SLAMF7, CD319) was highly and universally expressed on myeloma cells while having restricted expression in normal tissues. Elotuzumab (formerly known as HuLuc63), a humanized mAb targeting CS1, is currently in a phase I clinical trial in relapsed/refractory myeloma. In this report we investigated whether the activity of elotuzumab could be enhanced by bortezomib, a reversible proteasome inhibitor with significant activity in myeloma. We first showed that elotuzumab could induce patient-derived myeloma cell killing within the bone marrow microenvironment using a SCID-hu mouse model. We next showed that CS1 gene and cell surface protein expression persisted on myeloma patient-derived plasma cells collected after bortezomib administration. In vitro bortezomib pretreatment of myeloma targets significantly enhanced elotuzumab-mediated antibody-dependent cell-mediated cytotoxicity, both for OPM2 myeloma cells using natural killer or peripheral blood mononuclear cells from healthy donors and for primary myeloma cells using autologous natural killer effector cells. In an OPM2 myeloma xenograft model, elotuzumab in combination with bortezomib exhibited significantly enhanced in vivo antitumor activity. These findings provide the rationale for a clinical trial combining elotuzumab and bortezomib, which will test the hypothesis that combining both drugs would result in enhanced immune lysis of myeloma by elotuzumab and direct targeting of myeloma by bortezomib. [Mol Cancer Ther 2009;8(9):2616–24]
Toward computer-supported semi-automated timelines of future events
Authors: Lyra Alan de Oliveira , Barbosa Carlos Eduardo , de Lima Yuri Oliveira , dos Santos Herbert Salazar , Argôlo Matheus , de Souza Jano Moreira
Published: April 2023

During a Futures Study, researchers analyze a significant quantity of information dispersed across multiple document databases to gather conjectures about future events, making it challenging for researchers to retrieve all predicted events described in publications quickly. Generating a timeline of future events is time-consuming and prone to errors, requiring a group of experts to execute appropriately. This work introduces NERMAP, a system capable of semi-automating the process of discovering future events, organizing them in a timeline through Named Entity Recognition supported by machine learning, and gathering up to 83% of future events found in documents when compared to humans. The system identified future events that we failed to detect during the tests. Using the system allows researchers to perform the analysis in significantly less time, thus reducing costs. Therefore, the proposed approach enables a small group of researchers to efficiently process and analyze a large volume of documents, enhancing their capability to identify and comprehend information in a timeline while minimizing costs.
Botanical origin and chemical composition of bee pollens collected from Apis cerana hives domesticated in the Pauri Garhwal, Western Himalaya, India
Authors: Bagri Ajendra singh , Tiwari Prabhawati , Gloch Eza
Published: April 2023

The present investigation aims to determine the botanical origin and chemical composition of bee pollen samples (n =22) harvested from Apis cerana hives domesticated in Pauri Garhwal (Uttarakhand, India). The majority (95%) of the samples were unifloral in their botanical origin. All the identified pollens belonged to eighteen plant families, among which Rutaceae, Asteraceae and Brassicaceae were found dominant. The chemical parameters soluble sugars, starch, crude protein, amino acids and phenolic contents were analyzed calorimetrically and were found in the range from 0.2 to 26.09 mg/g, 0.22 to 11.04 mg/g, 13.40 to 191.41 mg/g, 2.01 to 6.48 mg/g, and 5.10 to 35.50 mg GAE/g, respectively. Statistically significant differences (p<0.05) were observed between the chemical contents of the analyzed samples and a moderate correlation (r= 0.40; n=22) was observed between total soluble sugars and crude protein. Bee pollens as a good source of nutrition, medicine and dietary supplement for both humans and bees, demonstrate the important need to define bee pollen from different regions of India in order to develop bee pollen quality standards.
Mapping Antecedents and Outcomes of Marginality and Social Exclusion among Small Landholders: A Systematic Review
Authors: Sikandar Furqan , Wang Hong Shu , Zahra Kanwal , Muhammad Yaseen Bilal , Ullah Saif , Shobairi Seyed Omid Reza
Published: April 2023

This study aims to review determinants of the social exclusion (SE) of small farmers in the agriculture sector, which is one of the key approaches to creating sustainable rural development and an integral part of the country’s economic development. The selected group's social and economic underpinnings play a vital role in their productive decision-making regarding rural development. As per the literature review, databases of peer-reviewed scientific publications, and official publications of the relevant fields from 2005 to 2020, it has been deduced that the literature lacks elucidated support on the small landholder (SLH) in defining their marginality and social exclusion. This study particularly attempts to fill this gap by reviewing the comprehensive research of said domains. A precise and effective list of main players in this field to the smallholders throughout the developing and developed countries has been produced. Findings indicate that government interventions in terms of the welfare system, credit facilities, agriculture resources, market access, and farmers’ migration significantly influence decreasing social exclusion, food security, and attainment of the SDGs. Moreover, educational systems through farmer social networks, farmer-based organizations, and farmer field schools help adapt to climate change and the latest agricultural technologies, increase livelihood choices, reduce poverty and inequalities, empower women, and improve the social status of farmers. This is ultimately and positively associated with the social inclusion of small farmers and sustainable economic development.
Адміністрацыйныя рэарганізацыі Мінскай рымска-каталіцкай дыяцэзіі ў канцы XVIII – пачатку ХХ ст.
Authors: Антановіч Зінаіда Васільеўна
Published: April 2023

Artykuł analizuje stosunek ludności i duchowieństwa mińskiej diecezji rzymskokatolickiej do zmian administracyjno-terytorialnych, które miały miejsce po wcieleniu tych terenów do Imperium Rosyjskiego. Autorka wyodrębniła cztery okresy zmian podporządkowania administracyjnego ziemi mińskiej. W przeciwieństwie do reorganizacji jednostek diecezjalnych innych wyznań chrześcijańskich, zmiany administracyjno-terytorialne mińskiej diecezji rzymskokatolickiej zależały nie tylko od decyzji władz państwowych, lecz musiały być również uzgadniane z papieżem. Inną cechą szczególną było przekazanie diecezji w administrowanie innym podmiotom bez jej terytorialnego rozdrobnienia, co umożliwiło wznowienie działalności rzymskokatolickiej diecezji mińskiej.
Medium Small Micro Enterprise (MSME) Development and Economic Growth: Causality Analysis
Authors: Jalunggono Gentur , Sugiharti Retno , Islami Fitrah Sari , Zahroti Puji Aisyah
Published: April 2023

As a business sector with a fairly large contribution to national output, government support for Micro, Small, Medium Enterprises (MSMEs) is increasingly being increased, even though the ratio of MSME credit to total national credit is still very small.  Capital difficulties are a classic problem faced by MSMEs, but the high growth of MSMEs is a gap that shows the resilience of MSMEs. Therefore, this study wants to analyze whether the existence of MSMEs encourages economic growth, or vice versa, economic growth must be boosted to increase MSMEs. This study investigates the causal relationship and long-term stability conditions between MSME credit distribution variables and Indonesia's economic growth in the 2011 - 2019 period, using Direct Error Correction Model causality on panel data. The estimation result shows that MSME credit distribution has a positive and significant relationship to economic growth only in a long term. On the other hand, the causal relationship between MSME credit and economic growth is not proven, which means that there is no reciprocal relationship between credit and economic growth, or said in here demand following hypothesis is not proven
Community-Based Empowerment: Semi-Systematic Literature Review (SSLR)
Authors: Prasetyani Dwi , Destiningsih Rian , Rosalia Amelia Choya Tia
Published: April 2023

The purpose of this study was to synthesize research results with the topic of community-based community empowerment in Indonesia using the Scopus database. The method used is a semi-systematic literature review (SSLR). Semi-systematic analysis shows that there are two main themes, namely the identification of scientific journals that contain articles on the topic of community-based community empowerment in Indonesia and the phenomenon of community-based community empowerment in Indonesia from previous studies. The findings in this study are publications on the topic of community-based community empowerment in Indonesia, the phenomenon of community-based community empowerment in Indonesia still can be explored more deeply considering the surge in articles related to this topic in 2020; Community empowerment is one of the strategies to reduce poverty in Indonesia. As a coping strategy, community empowerment is also provided with related regulations. The National Program for Independent Community Empowerment, empowerment of microfinance institutions (LKM), and micro-credit schemes and tourist villages are examples of the application of the concept of community empowerment in Indonesia, but the application still requires some improvements, for example by considering social capital such as local institutions, local wisdom Local customs, norms, and customs as an effort to apply the concept of community empowerment are getting closer to the main goal, namely reducing poverty and improving community welfare.
Determinants of Job Opportunities in Yogyakarta Special Regional Province
Authors: Surur Muhammad Miftahur , A'yun Indanazulfa Qurrota
Published: April 2023

The Republic of Indonesia has a goal to create a just and prosperous society as stated in the 1945 Law. To achieve this goal, it is necessary to carry out development activities. One of the unresolved development problems is employment. Therefore, the purpose of this study was to determine the effect of the minimum wage, education level, industry, Gross Regional Domestic Product (GDP) and government spending on employment opportunities in the Special Region of Yogyakarta. The data used is annual data from 2010–2019 and uses the Random Effect Model approach with the Generalized Least Square (GLS) method. The estimation results show that industry and GRDP have a positive and significant effect on job opportunities in the Special Region of Yogyakarta, while the minimum wage, education level, and government expenditure have a negative and insignificant effect on job opportunities in the Special Region of Yogyakarta.
Characteristics and Determinants of NEET Youth in Kalimantan Barat
Authors: SNA Dara
Published: April 2023

The change in population structure in Indonesia shows an increase in the young population. As an indicator to see youth's activeness in education and work, NEET has become one of the centers of attention for the government. The number of NEETs in West Kalimantan has increased over the past five years. It indicates that young people who do not work or attend school have not integrated into the labor market. This study investigates the characteristics and factors influencing NEET youth in West Kalimantan. The descriptive and inferential statistical method with a binary logistic regression model is the analytical approach taken in this study. This research use BPS data from the National Labor Force Survey (Sakernas) in August 2021, with a sample of 4,750 young people spread over 14 districts/cities of West Kalimantan Province. The study's findings stated that most NEET youth in West Kalimantan were female, with the highest proportion of women aged 20-24. In addition, NEET youth in West Kalimantan were unmarried youth. Gender, age, completed education, marital status, education of the Head of the Household, and significant disability status are the determinants that determine whether a person is more at risk of becoming a NEET in West Kalimantan in 2021, according to the determinant findings of this study. Some of the recommendations from this study are the suitability of the educational curriculum with the availability of employment, equitable distribution of educational facilities, and information convenience. Furthermore, we need skill training for the younger generation, especially for the disabled, so they can advance their home areas so that they can advance in their place of origin.
How does social innovation generate social impact? Contributions from a meta-synthesis
Authors: Rocha Ronalty Oliveira , Takahashi Adriana Roseli Wunsch , Segatto Andrea Paula
Published: April 2023

Objective: To analyze how social innovation actions and practices presented in case studies, generate social impact. Methodology: The meta-synthesis was adopted, which, by identifying empirical research (case studies) and establishing comparative analyses, revealed new possibilities for investigation, deepening and theoretical expansion. Results: The results show the heterogeneity of the concept and actions of social innovation, identify its promoters, driving and/or enabling elements, actor networks, and forms of social impact, and link social innovation and impact to other approaches and opportunities for innovation. Theoretical/Methodological contributions: The study was able to synthesize preponderant elements to reach social impact from social innovation actions, themes little explored in an integrated way. In addition, it explored the meta-synthesis method, reinforcing the application of this research strategy as a tool for building theories and identifying findings that surpass the original conclusions of primary case studies. Originality: Given the differences in social impact detection and measurement, and the lack of a standard for social impact generation through social innovation, this study summarizes empirical findings, categorizes, and identifies aspects and elements that condition social impact generation through social innovation. Social / Management Contributions: In addition to portraying conceptual aspects, drivers and forms of social impact, this study offers a discussion on the integration between driving agents, boosters and networks of actors that can help practitioners of social innovation, public and social managers in stimulating and generation positive results (social impact) from this innovation.
Effects of Graphite Flakes on the Material and Mechanical Properties of Polystyrene Membranes
Authors: Naqvi Asad A. , Awan Zahoor , Shaikh Asif Ahmed , Younas Mohammad
Published: April 2023

The use of polymer composite membranes has been widely increased to improve the mechanical and material properties. In this research, graphite flakes are used as nanofiller in polystyrene (PS) membrane to improve hydrophobicity, moisture blocking capacity, thermal stability, tensile strength, and gas separation ability. The membranes are prepared by a solution casting technique and are characterized by fourier transformation infrared spectroscopy, X-ray diffractometry, scanning electron microscope, thermal gravimetric analysis, water contact angle (WCA), moisture transmission rate (MTR), and mechanical testing. The prepared membranes are also tested to determine the O2 and N2 permeability and O2/N2 selectivity. The quantity of graphite flakes is varied from 0–1.0 wt% of PS. 0.7 wt% graphite-filled PS has shown the best results among all the prepared samples. The WCA of the PS membrane is increased from 97.3 to 114.803°, which shows that graphite flakes are well-suited to increase the hydrophobicity of the PS membrane. The MTR of 0.7 wt% graphite-filled PS shows that the membrane is well-suited for moisture blocking and also showed better thermal stability. Graphite flakes are also found suitable for increasing the tensile strength of the membrane. Also, the highest O2/N2 selectivity is achieved for 0.7 wt% graphite-filled membranes, which makes them suitable for gas separation operation. Furthermore, the potential application of graphite-filled PS membranes is also presented.
Accuracy and Consistency in Social Categorization Across Context, Motivation, and Time
Authors: Schwartzman Emily , Alaei Ravin , Rule Nicholas O.
Published: April 2023

Photos provide a literal snapshot of a person in a particular context at a specific moment in time. Previous studies have found that people can accurately categorize others from single photos of their faces along various social dimensions, yet this research typically assumes that one photo of an individual representatively samples other photos of the same individual. Across four studies, we investigated this assumption by testing the consistency of perceptions of social categories (viz. sexual orientation and political affiliation) based on multiple photos of the same individuals. We found that judgments of social categories exceeded chance and significantly correlated across different photo contexts, across variability in targets’ motivations, and across time. These data supplement earlier work showing similar consistency for other types of social judgments. Thus, single face photos can consistently convey some aspects of an individual's appearance.
The dynamics of the nutrients in degraded Vertic Endoaquepts of rainfed rice fields with soil ameliorant and soil tillage management
Authors: Al Viandari Nourma , Wihardjaka Anicetus , Pulunggono Heru Bagus , Suwardi Suwardi , Sutriadi Mas Teddy
Published: April 2023

Intensive land use in the long term can cause land degradation, affecting soil fertility, especially on Vertic Endoaquepts in Pati that have been managed as rainfed rice fields. The characteristics of rainfed rice fields are low nutrient availability and rice yields. This study aimed to determine the effect of tillage depth management and soil ameliorants on nutrient availability, plant uptake, and rice yield in rainfed rice fields. The field experiment that was conducted at farmer’s field used a split-plot design. The main plot was the treatment of tillage depth treatments (OT), with depths of 10 cm (T1) and 20 cm (T2). The subplots were ameliorant treatments (A), consisting of A1 = sugarcane leaf compost, A2 = rice straw compost, A3 = chicken manure, and A4 = cow manure, with each dose of 5 t ha-1. The Inpari 32 rice variety was grown for 95 days. Available N, P and K of the soil were measured at 0, 62, and 94 days after transplanting (DAT). Plant N, P, and K contents, plant height, number of tillers, and rice yield were measured at 62 DAT. The results showed that the interaction of soil depth and ameliorant significantly affected soil available P and K but had no significant effect on soil available N. Ameliorant treatment of cow manure significantly increased rice yield.
Determining the clinical and experimental findings of people with COVID-19
Authors: Vahidian Fatemeh , Najafi Souzan , Shahgoli Vahid Khaze , Safarzadeh Elham , Akbarzadeh Moloud , Hashemy Seyed Isaac
Published: April 2023

Introduction: Coronavirus disease 2019 (COVID-19) is responsible for severe acute respiratory syndrome. The present study planned to evaluate the accuracy of laboratory parameters and clinical findings in predication of the infected cases through RT-PCR. Methods: All related laboratory tests of 180 cases (62.8% male and 37.2% female) with an average of 62 years old (45.3-69) were performed by several laboratory techniques. The obtained results as well as other clinical and biography findings of the patients during the treatment and recovery were compared and analyzed to find out the possible relationship among the considered parameters. Results: The considered hematological and biochemistry factors were completely different in all cases regardless to their health and lifestyle condition, including being at ICU, being addict or not, whether having previous diseases or not and others. Conclusion: COVID-19 has brought a huge burden to the health system and infected patients, especially those who have a background of chronic diseases or addicted to some drugs.
Oxygen injury in neonates: which is worse? hyperoxia, hypoxia, or alternating hyperoxia/hypoxia
Authors: Uhal Bruce
Published: April 2023

Premature birth results in an increased risk of respiratory distress and often requires oxygen therapy. While the supplemental oxygen has been implicated as a cause of bronchopulmonary dysplasia (BPD), in clinical practice this supplementation usually only occurs after the patient’s oxygen saturation levels have dropped. The effect of hyperoxia on neonates has been extensively studied. However, there is an unanswered fundamental question: which has the most impact- hyperoxia, hypoxia or fluctuating oxygen levels? In this review, we will summarize the reported effect of hypoxia, hyperoxia or a fluctuation of oxygen levels (hypoxia/hyperoxia cycling) in preterm neonates, with special emphasis on the lungs.
Expenditure on services indicator of quality of life assessment
Authors: Mihăilescu Adina
Published: April 2023

The disparities between urban and rural regarding the structure of the employed population according to the professional status represent the reflection of the structure of the types of jobs and economic activities corresponding to each of the two areas of residence; in cities most worked in non-agricultural activities, in villages in agricultural activities. Poverty trends in Romania have begun to decline, regardless of the assessment methods used. After 2010-2011, the general interest in assessing absolute poverty, severe / extreme poverty and food poverty decreased massively, at European level but also in Romania, following another indicator closer to relative poverty, called the risk of poverty and social exclusion. The lack of financial resources of the Romanian labor force determined a large part of the households not to be able to pay the consumption of utilities on time. The share of households that used savings to cover current expenses was 6.8%, those that borrowed from relatives, friends or others 6.1%, and those that needed financial aid , without the obligation to return, from relatives, friends or other persons was 11.5%. An additional work to obtain the necessary resources to cover current expenses was provided by 9.3% of households. The statistical research "Living conditions of the population in Romania", in 2019, reveals that for one in five households the current expenses do not pose special problems, these being exceeded quite easily, easily or even very easily.
Marriage in Secret According to Islam and Catholic: A Comparative Study on Religious Laws
Authors: Tjatur Raharso Alphonsus , Barak Antonius
Published: April 2023

This article discusses secret marriage from another perspective, namely in the form of a comparative study of religious law between Islam and Catholicism. This research aims to find similarities and differences between the two religions in assessing and regulating secret marriages. This study found that both religions recognize secret marriage as an uncommon and not ideal marriage. Both religions see the disadvantages and harms of secret marriage. This study found some key differences. In Islam, sirri marriage is not created by religious doctrine, but are practices carried out by several people which is subsequently judged and regulated by religious law. Whereas in Catholicism, secret marriage are officially created by the highest legislator of the Church. In Islam, unregistered marriage often colludes with polygamy, while in the Catholic Church secret marriage is carried out while upholding the essential nature of marriage: monogamous and indissoluble. In Islam, sirri marriage is not recorded anywhere, while secret marriage in the Catholic Church is recorded internally in the diocesan secret archives. This study raises mutual respect among adherents of both religions regarding secret marriages. This study also encourages further studies on the problem of the two religions facing civil lawsuits regarding marriage registration.
Resiliencia académica de adolescentes, factores asociados y metodología empleada:
Authors: Vera Noriega Jose Angel , Gutiérrez Cervantes Juan Carlos
Published: April 2023

Tema y alcance. En México más del 14% de los adolescentes abandonan sus estudios y más del 64% obtienen niveles limitados en conocimientos básicos. El estudio de la resiliencia académica surge como una propuesta para contrarrestar las problemáticas de deserción escolar, bajos rendimiento académico y violencia escolar. El presente trabajo tiene como propósito realizar una revisión sistemática y exhaustiva para conocer los factores de socialización y psicoemocionales que se han asociado a la resiliencia académica en contexto adolescente y la metodología empleada en dichos estudios. Características. Se realizó una búsqueda exhaustiva y sistemática utilizando el método PRISMA en las bases de datos Scopus, Science Direct, Redalyc, Eric, Springer, Ebsco, Psycinfo, y Google Scholar; considerando artículos publicados de enero de 2010 hasta mayo de 2021, empleando las palabras clave academic resilience, adolescents, teenagers, socioemotional, social factors, psychological factors, resiliencia académica, adolescentes, socioemocional, factores sociales y factores psicológicos, ubicados en el título, resumen y palabras clave. Hallazgos. Se seleccionaron un total de 30 artículos que cumplieron con los criterios de selección e inclusión. Los factores más relevantes que se han asociado con la resiliencia académica son el apoyo parental emocional, el monitoreo estricto hacia las tareas escolares, la autorregulación, la autoeficacia personal y escolar y la buena relación con profesores y compañeros. La metodología cuantitativa que utiliza estadística multivariada es la que se identificó con mayor frecuencia y la investigación experimental con menor frecuencia. Conclusiones. Los factores de socialización y psicoemocionales se pueden dividir en tres grandes grupos: familiares, personales y escolares. Se recomienda desarrollar modelos explicativos que permitan una mejor comprensión de la resiliencia académica, que integren los factores mencionados y empleando metodologías estadísticamente apropiadas.
narrativa visual de una arteducadora bubi y gallega viaja a las aulas de sus dos orígenes
Authors: López-Ganet Tiffany
Published: April 2023

Introducción: El presente artículo comparte las posibilidades de la autobiografía para explorar por medio de las artes la realidad migrante, el género, la raza o el sentido de pertenencia y compartir esa búsqueda en las aulas. Metodología: Partiendo de la historia de vida de la autora —una mujer negra, bubi (pueblo autóctono de la isla de Bioko, Guinea Ecuatorial) y gallega (Galicia, España) que habita un territorio mayoritariamente blanco—, se crea una metodología de Investigación Basada en las Artes protagonizada por recuerdos visuales extraídos del archivo fotográfico doméstico y microrrelatos conectados con experiencias racistas. Resultados: Conectando la intimidad de esa autopercepción con un discurso afro, común y colectivo, se extrapolan las vivencias completándolas con referentes artísticos y bibliográficos, obteniéndose así estrategias artísticas educativas para acercar al alumnado un discurso decolonial, antirracista y afrofeminista con el que trabajar el autoconocimiento, el respeto y la no discriminación en el grupo. Conclusiones: El viaje de la autora como hija de mujer migrante cuenta su realidad diaspórica por medio de la foto, el vídeo, el collage y la narrativa identitaria y llega a las aulas de distintos centros educativos de España, Canadá, India y Guinea Ecuatorial. De todos ellos, este artículo se centra en la puesta en práctica en sus dos orígenes: Oleiros (A Coruña, Galicia, España) y Ela Nguema (Malabo, Guinea Ecuatorial).
Improved Reinforcement Learning in Asymmetric Real-time Strategy Games via Strategy Diversity
Authors: Dasgupta Raj , Kliem John
Published: April 2023

We investigate the use of artificial intelligence (AI)-based techniques in learning to play a 2-player, real-time strategy (RTS) game called Hunting-of-the-Plark. The game is challenging to play for both humans and AI-based techniques because players cannot observe each other's moves while playing the game and one player is at a disadvantage due to the asymmetric nature of the game rules. We analyze the performance of different deep reinforcement learning algorithms to train software agents that can play the game. Existing reinforcement learning techniques for RTS games enable players to converge towards an equilibrium outcome of the game but usually do not facilitate further exploration of techniques to exploit and defeat the opponent. To address this shortcoming, we investigate techniques including self-play and strategy diversity that can be used by players to improve their performance beyond the equilibrium outcome. We observe that when players use self-play, their number of wins begins to cycle around an equilibrium value as each player quickly learns to outwit and defeat its opponent and vice-versa. Finally, we show that strategy diversity could be used as an effective means to alleviate the performance of the disadvantaged player caused by the asymmetric nature of the game.
Aversión al riesgo al tomar decisiones económicas, efecto certeza y estimación de probabilidades
Authors: Aguado-Franco Juan Carlos
Published: April 2023

se ha observado empíricamente que la violación de los principios de la teoría de la utilidad se produce con frecuencia en la toma de decisiones en entornos de riesgo. Esto llevó a la formulación de la teoría de las perspectivas en la que, además de tener en cuenta la diferente consideración de las pérdidas y las ganancias, así como la postura ante el riesgo de los decisores, mostrando aversión por el riesgo en las ganancias y amor por el riesgo en las pérdidas, se enmarca el efecto certeza. Según el efecto certeza, los decisores tienen tendencia a infravalorar los pagos que son meramente probables, en comparación con aquellos que se obtienen con certeza. Allais mostró la irracionalidad que se produce en la toma de decisiones en este contexto. Por otro lado, para tomar decisiones arriesgadas, es necesario conocer cómo funcionan las probabilidades. Con el objetivo de determinar las relaciones existentes entre la aversión al riesgo, el efecto certeza y el conocimiento básico dela teoría de las probabilidades, se diseñó un estudio experimental en el que se constató, utilizando una formulación basada en la paradoja de Allais, que quienes tienen mayores conocimientos de los principios de la probabilidad muestran una mayor aversión al riesgo, pero el hecho de incurrir en el efecto certeza, sin embargo, es una circunstancia que no se ve afectada significativamente por dicho conocimiento.
Examining The Rules in Nuclear and Origin Families Living in Turkey
Authors: ULUSOY Yağmur , KILIÇARSLAN Suat
Published: April 2023

This study aimed to examine married couples’ descriptions of themselves, their spouses, mothers, and fathers and their views about the rules in their nuclear and families of origin. The study group consisted of 12 married individuals, including eight females and four males, who were aged between 23 and 49, were not married to another participant, lived in the central county of a province in the central Anatolia region. The study used the phenomenological research design, which is one of the qualitative research approaches. The data were collected through semi-structured interviews, one of the qualitative research techniques, and analyzed with the content analysis method. The results of the study indicated that altruism and submissiveness were the common and prominent descriptions of the female participants about themselves and the descriptions of all participants about their mothers, whereas cold and distant were common descriptions of the participants about their mothers and fathers. It was found that the rules about couple relationships, family relationships, parenting, and spirituality/values were similar in nuclear and families of origin but that although the rules of the relationships with the family of origin/relatives and budget management were expressed in nuclear families, they were not expressed in families of origin.
Opportunities and achievements of using massive parallel sequencing in the diagnosis of neurodevelopmental diseases
Authors: Kozhanova T. V.
Published: April 2023

The contribution of genetic factors to development of neurological diseases has long been recognized, and the majority of the advances coupled to using molecular genetic technologies resulted in identifying genes associated with the pathology of developing nervous system. The review is aimed at demonstrating opportunities and achievements of using massive parallel sequencing technology in the diagnosis of a disease with damage to nervous system. Currently, next-generation sequencing (NGS) technology in the genetic diagnosis of epilepsy relies on targeted gene panels, whole exome sequencing or whole genome sequencing. Integrating genetic and genomic analysis into clinical practice to establish clear molecular diagnoses for previously undiagnosed patients will avoid further unnecessary diagnosis and therefore lead to greater healthcare cost savings over time. The use of biomarkers will contribute to the prediction of disease outcome and therapy decision-making.
Cohort study of epileptic patients with family history of epilepsy
Authors: Kotov A. S. , Firsov K. V.
Published: April 2023

Background. An impact of burdened family history on epilepsy course and disease outcome remains insufficiently studied.

Objective: assessing the rate of achieving remission in epileptic patients with/without burdened family history.

Material and methods. The study included 660 patients with a specified family history of epilepsy divided into three groups: Group 1 (n=192) – patients with genetic forms of epilepsy (56 with and 136 without family history); Group 2 (n=148) – patients with structural forms of epilepsy (16 with and 132 without family history); Group 3 (n=320) – patients with epilepsy of unknown etiology and unspecified epilepsy (48 with and 272 without family history). In Group 1, there were significantly more patients with burdened family history (29.2%) than in Group 2 (10.8%) (p<0.01) and Group 3 (15%) (p<0.01). ><0.01). Anamnesis collection, clinical and neurological examination, routine electroencephalography (EEG) and/or video-EEG monitoring, brain magnetic resonance imaging and analysis of medical records were carried out. Therapy was adjusted.

Results. In all groups, patients with burdened family history tended to have earlier onset of epilepsy. The frequency of seizures at the onset of the disease did not depend on identified burdened family history of epilepsy. In Group 1, the effectiveness of treatment (rate of achieving remission) in both subgroups was almost identical (p>0.05), whereas in Groups 2 and 3 it tended towards a greater effectiveness of therapy in patients without family history.

Conclusion. Epilepsy familial burden depends on the form of the disease and has limited prognostic value regarding disease course and likelihood of achieving remission. It is necessary to increase availability of genetic studies and identify genetic substrate of various epileptic syndromes.
Malignant bowel obstruction: a comparison among pre-operative factors, surgical approaches, and survival. Is surgery worthwhile?
Authors: G. Caldas Tarsila , A. Pinto Rodrigo , R. Nahas Caio S. , E. Corbi Leonardo , R. Júnior Ulysses , F. S. Marques Carlos
Published: April 2023

Background: Malignant bowel obstruction (MBO) is defined as the evidence of obstruction distally to the Treitz ligament in the presence of a malignant peritoneally disseminated neoplasm. Patients with this condition suffer from decreased quality of life due to impaired food intake, recurrent nausea, and abdominal pain. The objective was to investigate the outcome of patients with MBO surgically treated, considering post-treatment survival, surgical morbidity, and length of hospital stay, in order to assess the efficiency and impact of surgery at this advanced stage of disease.
Methods: We reviewed retrospectively data collected from 198 patients diagnosed with MBO at Instituto do Câncer do Estado de São Paulo (ICESP), operated between 2018 and 2021.
Results: Among preoperative factors, advanced stages and poor clinical status were associated with earlier death (stage IV had 4.53 higher chance of death). On the other hand, patients considered candidates for invasive life support measures had longer postoperative survival (non-candidates had a chance 1,000,000 times higher of death). Primary diagnosis also showed to be an important risk factor: ovary malignancies had higher risk of surgical complications (OR of 14.28), when compared to gastric and colon cancers. Considering intraoperative factors, patients who underwent resections had better long-term survival (9.9 months) than those who underwent bypass (1.3 months) or stomas (2 months); p=0.017. Finally, considering post-operative factors, long-term survival was associated with shorter hospital stay (p=0.001).
Conclusions: Medical and surgical treatment should be employed on a case-by-case basis, after taking into consideration multiple pre-operative factors, such as KPS and primary tumor stage.