bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison of Short-term Outcomes Following Minimally Invasive (Endoscopic/Robotic) vs Open Thyroidectomy for Patients With Thyroid Cancer
Authors: Li Tingting , Gui Yu , Cui Xiang , Wu Xin , Yang Xi , Liu Jing , Li Shichao , Chen Li
Published: January 2025

Background Selection between open thyroidectomy (OT) and minimally invasive (endoscopic/robotic) thyroidectomy (MT) for patients with thyroid cancer has been a subject of considerable debate. Comprehensive analysis of the short-term outcomes of endoscopic thyroidectomy (ET), robotic thyroidectomy (RT) and OT for thyroid cancer using a large-scale dataset is important.

Methods This cohort study evaluated the outcomes of patients receiving ET, RT vs OT for thyroid cancer from January 1, 2003, to December 31, 2022. Propensity score matching was performed among patients treated with ET, RT or OT to balance covariates distribution. This study involved single-institutional patients (aged 18-70) who had undergone ET, RT or OT for thyroid cancer.

Results The study included 11066 thyroid cancer patients (OT group: mean [SD] age, 42.45 [10.84] years; ET group: mean [SD] age, 36.75 [9.32] years; RT group: mean [SD] age, 40.27 [10.42] years). After PSM for demographic and clinical characteristics, 908 matched pairs of patients (ET vs. OT) and 1480 matched pairs (RT vs. OT) were included for further analysis. Complication analysis revealed that RT was associated with a lower rate of transient hypoparathyroidism (339 [22.9%] vs. 687 [46.4%]; p <0.001), a lower rate of permanent hypoparathyroidism (4 [0.3%] vs. 16 [1.1%]; p =0.012) and a lower rate of transient recurrent laryngeal nerve injury (63 [4.3%] vs. 89 [6.0%]; p =0.037).

Conclusion This cohort study analyzed the short-term outcomes between ET, RT and OT in a large sample of patients with thyroid cancer over a period of two decades. PSM provided a comparable cohort, and the results suggested the advantage of RT, which reduced Clavien‒Dindo grade Ⅰ complications in the surgical treatment of thyroid cancer.
Formulation of flame-retardant waxes and evaluation of combustion characteristics of treated wood using mass loss calorimetry
Authors: Lee Hyung Woo , Jung Jae Hee , Lee Jong-Shin , Park Soon , Yoon Seon-Mee
Published: January 2025

The objective of this study was to synthesize flame-retardant wax by nano-sizing a previously developed flame-retardant with favorable performance characteristics. Additionally, this study assessed the leaching resistance of wood treated with flame-retardant wax. The findings revealed that wood treated with flame-retardant wax demonstrated no notable change in the weight loss rate before and after weathering treatments. In contrast, wood treated exclusively with flame retardants exhibited a discernible increase in the extent of weight loss. Furthermore, the leached phosphorus content was measured during the weathering process, revealing that the amount extracted from wood treated with flame-retardant wax was approximately 1/20 times of that extracted from wood treated with flame-retardant agents. Therefore, that wood treated with flame-retardant wax demonstrated superior flame-retardant performance before and after weathering treatments.
Nature’s way-our way: A journey through the co-creation and sharing of an Indigenous physical literacy enriched early years initiative
Authors: Froehlich Chow Amanda , Wahpepah Kathy , Humbert Louise , Houser Natalie , Brussoni Mariana , Erlandson Marta , Gannon Amanda , Larmour Ashley , Stevenson Erica , Riley Kathryn , Ali Fatima
Published: January 2025

Early years are a critical time in the healthy development of young children. It is essential for children to develop healthy bonds with family members to increase well-being. Colonialism has resulted in the loss of many Indigenous activities, intergenerational teachings and relationship-building strategies that encourage wholistic health-promoting behaviours. Research focused on physical activity behaviours among early years children has had limited success. To address these challenges, the Western concept of physical literacy that applies a wholistic approach to physical activity by focusing on physical, social, emotional, and spiritual wellness can align with many Indigenous Ways of Knowing, Being and Doing. 
Purpose: Our multi-cultural team embarks on a journey to co-create, and expand a physical literacy enriched and culturally rooted initiative designed to promote wholistic wellness. 
Methodology: Etuaptmumk (Two-eyed Seeing) guides the team through braiding Indigenous Ways of Knowing,Being and Doing in early childhood wellness and land- and nature-based games alongside Western knowledge of developing physical literacy and promoting risky/ adventurous play. We apply a pre-mid-post design for the meaningful evaluation of the Nature’s Way-Our Way initiative. 
Impact: Partnering with communities, we aim to produce 40-45 activity cards to promote physical literacy and wholistic health in Indigenous and non-Indigenous communities.
Creating a Sense of Belonging in the Academy: An Example of a Métis-Centred Space
Authors: Fowler Lucy , Forsythe Laura
Published: January 2025

As post-secondary institutions continue the slow move towards indigenization and reconciliation, more Indigenous-centred spaces are created. But how many of those spaces are Nation-specific? In this article, we describe one example of a Nation-specific gathering, the Métis Research Symposium, and the impact that the gathering had on the mostly-Métis audience, including the enhanced sense of belonging and connection that the respondents reported. We advocate for institutions and administrators to shift towards creating more Nation-specific opportunities for students, faculty, and staff at all levels.
Late-Onset Sepsis Among Extremely Preterm Infants During the COVID-19 Pandemic
Authors: Mukhopadhyay Sagori , Kaufman David A. , Saha Shampa , Puopolo Karen M. , Flannery Dustin D. , Weimer Kristin E. D. , Greenberg Rachel G. , Sanchez Pablo J. , Eichenwald Eric C. , Cotten Charles M. , Stoll Barbara J. , Laptook Abbot
Published: January 2025

OBJECTIVES

To compare incidence of late-onset sepsis (LOS) among extremely preterm infants before and during the COVID-19 pandemic.

METHODS

Multicenter cohort study of infants with birthweight 401 to 1000 g or gestational age 22 to 28 weeks. LOS was defined as a bacterial or fungal pathogen isolated from blood or cerebrospinal fluid culture obtained after 72 hours of age. Primary outcome was LOS incidence calculated as incidence proportion (LOS cases among all admissions) and incidence rate (LOS events/1000 patient days). A multivariable Poisson regression model was used to compare the adjusted risk of LOS incidence proportion before (1/1/18–3/31/20) and during the pandemic (4/1/20–12/31/21). An interrupted time series analysis using a generalized linear mixed model with center as a random effect was used to compare LOS incidence rates during the 2 periods.

RESULTS

Among 6509 eligible infants, LOS incidence proportion was not different before (18.2%) and during the pandemic (16.9%; P = .18). The adjusted relative risk (95% CI) for LOS was 0.93 (0.82–1.05) and for LOS or mortality was 0.98 (0.88–1.08) during the pandemic compared to the period before the pandemic. In the interrupted time series analysis, there was no significant change in LOS incidence rates at the start of the pandemic (0.219, 95% CI, −0.453 to 0.891) or microbiology of LOS, and change in trends of LOS incidence rates before and during the pandemic was not significant (−0.005, 95% CI, −0.025 to 0.015).

CONCLUSIONS

In a large multicenter study of extremely preterm infants, rates of LOS remained unchanged during the pandemic.
Severe infestation by tropical bedbugs (Cimex hemipterus) in Medellín, Colombia. Case series
Authors: Porras-Villamil Julián Felipe , Sáez-Durán Sandra , Trelis-Villanueva María , Bueno-Marí Rubén , Fuentes Màrius Vicent
Published: January 2025

Abstract
Introduction: Bedbugs are obligate hematophagous parasites that are difficult to control and eradicate, which can cause a great psychological and economic impact. This paper presents three clinical cases secondary to a tropical bedbug infestation that were morphologically and genetically identified.
Case presentation: A three-member family (mother aged 53 years and two daughters aged 25 and 22 years) living in Medellín (Colombia) requested a private teleconsultation due to generalized pruritus and psychological symptoms (feeling of isolation, anxiety, difficulty sleeping, and jumpiness). During the appointment, it was found that the patients presented subtle welts on the upper and lower extremities. Therefore, a visit to the family home was scheduled, finding 155 insects that were later identified as Cimex hemipterus. The patients were prescribed symptomatic treatment and informed about measures to control infestations. A pest control company made several visits to eliminate the bed bugs, but they were ineffective. Finally, the insects were eradicated after 3 months of meticulous daily cleaning with steam and heat.
Conclusion: These cases confirm the presence of a tropical bedbug (C. hemipterus) in Colombia and illustrate the significant psychological burden that bedbug infestations can cause and the difficulty of controlling them, thus making this issue an important public health problem.
O SER HUMANO: HOMO RELIGIOSUS: da negação à aceitação da Religião e/ou de Deus
Authors: Armando Vicente José
Published: January 2025

O ser humano, ao longo da história, tem demostrado sua ligação com a manifestação da crença. A relação entre o ser humano e o divino, que compõe, como instrumento primordial, a religião, sempre esteve presente nos mais diversos povos ao redor do mundo. A transcendência, como característica inata do ser humano, manteve seu espaço na organização das sociedades. A busca pela verdade, norteada pela fé, tornou-se um elo entre os seres individuais, promovendo a construção de coletividade pautada por essa relação. Quer dizer, desde os tempos longínquos o ser humano busca certeza absoluta para sua própria existência. O ser humano, pela sua natureza, é um homo religiosus. É inegável que a religião é um fenômeno complexo e constitui, por isso, um estímulo forte para várias interpretações. De fato, a religião é como reservatório inesgotável de significações utópicas.
Changes in Halal Product Guarantee Regulations Perspective of Legal Politics and Consumer Rights Protection
Authors: Sopiah Evi , Safe'i Abdulah , Marlina Elly , Suhendar Heris
Published: January 2025

A halal product guarantee is a legal certainty regarding the halal status of a product produced by a business entity, which is evidenced by the issuance of a halal certificate by the government. The focus of the research examines the changes in halal product guarantee regulations within the Omnibus Law using a legal politics and consumer legal protection approach. This research is normative legal research whose object of study is the history of changes to halal product guarantee regulations in the Job Creation Act and its implications for consumer legal protection. Legal and non-legal materials were obtained from document studies and literature studies in the form of academic texts, draft laws, problem inventory lists, laws and regulations related to halal product guarantees and consumer protection, journals, and other documents relevant to the research issue. Changes in halal product guarantee regulations are a strategic step to strengthen the national halal industry and increase the competitiveness of Indonesian halal products in the global market. Changes in regulations prioritizing business actors' statements as the basis for halal certification can overcome the low awareness of business actors regarding halal certification obligations. In addition, changes to halal product guarantee regulations provide legal protection for consumers through guarantees of legal certainty, both preventively and repressively through self-declaration policies by implementing special limitations, conditions, and criteria for halal certification obligations for micro and small businesses, as well as administrative sanctions. and criminal penalties for business actors who commit acts or violations that can harm consumers.
The relationship between long-term memory ability and instructed second language learning: Evidence from research and implications for practice
Authors: Pili-Moss Diana
Published: January 2025

Re ability to encode, store and retrieve linguistic information long-term is key to effective second language learning and use. Alongside its importance for second language acquisition theory, investigating the role of long-term memory is fundamental to advance pedagogical implementations, in the effort to optimise language instruction and maximise its effectiveness by catering for individual learners’ differences. In order to achieve these goals, the role of variability in explicit and implicit long-term memory has been investigated employing methodology developed in neuropsychological research in laboratory settings. More recently, this research programme has extended to less controlled, but also more ecologically-valid, instructed contexts, included in the foreign language classroom. Ris article aims at reviewing these studies, as well as at providing an overview of recent research advancing new proposals on how the findings of long-term memory research can be implemented to benefit L2 pedagogy.
MAIDEN, John. Age of the Spirit: Charismatic Renewal in the Anglo-World and Global Christianity 1945–1980
Authors: Kay William K
Published: January 2025

MAIDEN, John. Age of the Spirit: Charismatic Renewal in the Anglo-World and Global Christianity 1945–1980. Oxford: Oxford University Press, 2023. ix + 261pp. Hbk. ISBN: 9780-98847496. £78.
NEL, Marius. The Prosperity Gospel in Africa: An African Pentecostal Hermeneutical Consideration
Authors: Ayelotan Claire Princess
Published: January 2025

NEL, Marius. The Prosperity Gospel in Africa: An African Pentecostal Hermeneutical Consideration. Eugene, OR: Wipf & Stock, 2020. 296pp. Pbk. ISBN: 9781725266629. £28.44.
Small-Scale Rubber Farmers and Their Relevance to Rubber Production in Nigeria: A Comprehensive Review
Authors:   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Uwumarongie A.M.D. , Emuedo, O.A. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Uzunuigbe E.O ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Omorogbe J.A. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Ugiagbe-Ekue U. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Chukwuka A.N. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Aghedo S.O. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Momoh, R.L. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria., Musa S.O. ,   Research Outreach Department, Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria, Fashoranti F.M. ,   Research Operations Department, Rubber Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria, Idahosa E.O. ,   Research Outreach Department, Research Institute of Nigeria, Iyanomo. P.M.B 1049, Edo State, Nigeria
Published: January 2025

The rubber industry in Nigeria plays a crucial role in the agricultural economy, with small-scale farmers contributing a significant share of the national rubber output. Despite their central role, small-scale rubber farmers face several challenges that hinder their productivity and potential for growth. This review delves into the socio-economic importance of small-scale rubber farming in Nigeria, the constraints faced by these farmers, and suggests strategies for improving their productivity. By highlighting relevant literature and recent findings, the review underscores the importance of policy intervention and investment in addressing the challenges faced by smallholder farmers in Nigeria’s rubber industry.
PREFÁCIO
Authors: Claudio André
Published: January 2025

Os textos que compõem esta obra especial, organizados com dedicação pela nossa Comissão de Egressos, representam muito mais que uma compilação de pesquisas.
Modelo estadístico para conocer el nivel en Competencias Genéricas y Pensamiento Numérico en los Egresados del Ciclo Técnico Profesional en Barranquilla
Authors: Duran Sonia , Barrera Alonso , Ballesta Marlene , Ramirez Javier
Published: January 2025

El objeto de este proyecto es diseñar un Modelo Estadístico que permita conocer cuánto valor agrega la Institución Universitaria ITSA de la ciudad de Barranquilla (Colombia) en la transferencia de conocimientos en Competencias Genéricas y Pensamiento Numérico a Egresados del Ciclo Técnico Profesional mediante la predicción de resultados de pruebas estandarizadas profesionales a partir de las pruebas a nivel secundario versus los resultados reales desde el año 2013 al 2016. Se recolecto la información de un total de mil seiscientos (1600) egresados de la Institución Universitaria ITSA que presentaron la prueba Saber Pro en los periodos 2012-1 al 2015-3 de estos datos se tomó una muestra representativa de trescientos veintiséis (326) egresados de los programas del Ciclo Técnico Profesional de la Institución. Esta actividad se desarrolló mediante un requerimiento a la Oficina de Sistema y Egresados, también se utilizó la información suministrada por las plataformas virtuales que ofrece el ICFES en su página web. Este modelo permitió revisar e identificar falencias en los métodos y estrategias implementadas en la transferencia de conocimiento.
¿Leer en texto impreso o en Smartphone? Oportunidades y amenazas para Educar del pensamiento crítico
Authors: Trillos-Pacheco Juan José , Ballesteros Valencia Harold
Published: January 2025

El artículo da cuenta de los resultados de la investigación, ¿Leer en texto impreso o en Smartphone? oportunidades y amenazas para educar el pensamiento crítico, cuyo objetivo buscaba determinar cuáles son las oportunidades y amenazas para los estudiantes universitarios al tratar de comprender y explicar textos mediante lectura en papel y Smartphone. La muestra está conformada por 90 estudiantes de dos universidades, distribuidos en un grupo A, que leyó en papel y el grupo B, que leyó en Smartphone. Ambos grupos, se sometieron a 16 sesiones de estudio en clase, en las que se les evaluó, mediante una escala de Likert compuesta de cinco categorías, la compresión y el grado de pensamiento crítico logrado. Las conclusiones señalan que el ejercicio de lectura comprensiva en texto impreso, ofrece mayores probabilidades para el desarrollo, adquisición y entrenamiento del pensamiento crítico, en tanto la lectura en Smartphone resultó poco favorable para lograr la concentración y enfoque en tareas de largo aliento, pero una oportunidad para ampliar los horizontes epistémicos en estudiantes que han adquirido previamente una disciplina y metodología de estudio.
Antibodies to low-density lipoproteins modified by malonic dialdehyde: contents in blood and role in atherogenesis
Authors: Ivanova A. A. , Dmitrieva A. A. , Denisenko A. D.
Published: January 2025

In this work, we determined the content of antibodies to low-density lipoproteins modified by malondialdehyde, the concentration of circulating immune complexes cholesterol and oxidized low-density lipoproteins in the blood of healthy individuals and patients with various manifestations of atherosclerosis. In addition, the effect of antibodies to low-density lipoproteins modified with malondialdehyde on the interaction of such lipoproteins with macrophages was studied. 253 persons were examined: healthy individuals (59 people), patients with preclinical atherosclerosis (25 people) and patients with coronary artery disease (169 people). It was found that the concentration of circulating immune complexes cholesterol in plasma was increased in patients with coronary artery disease compared with healthy individuals and patients with preclinical atherosclerosis, while oxidized low-density lipoproteins content did not differ between patients groups. At the same time, a positive correlation oxidized low-density lipoproteins plasma concentration with circulating immune complexes cholesterol content was found in patients with atherosclerosis. The plasma level of IgG antibodies to malondialdehyde-modified lipoproteins was significantly reduced in patients with coronary artery disease compared with healthy people and patients with preclinical atherosclerosis. While the level of IgM antibodies to malondialdehyde low-density lipoproteins practically did not change in patients with atherosclerosis independently of disease severity. It was shown that specific antibodies vastly reduced malondialdehyde low density lipoproteins cytotoxicity and ability to induce cholesterol esters accumulation in macrophages derived from human peripheral blood mononuclear cells. Thus, the data obtained indicate that anti-lipoprotein antibodies may have a protective effect by preventing cell death and reducing the accumulation of cholesterol esters in macrophages when they interact with modified low-density lipoproteins, i.e. prevent the foam cells formation.
Effect of rifampicin on Toll-like receptor system gene expression in brain structures of rats with prenatal alcohol exposure
Authors: Airapetov M. I. , Eresko S. O. , Mikhailova A. A. , Sukhanova D. D. , Ignatova P. D. , Lebedev A. A. , Bychkov E. R. , Shabanov P. D.
Published: January 2025

Alcohol intake during pregnancy may affect the normal course of fetal development, causing the symptoms of fetal alcohol spectrum disorders (FASD). There is evidence that a number of prenatal pathologic conditions exhibit altered expression of several pro- and anti-inflammatory cytokines. In our study, we focused on studying expression of numerous pro- and anti-inflammatory cytokine genes in the forebrain and temporal regions of rat brain during the postnatal development, thus modeling prenatal alcohol exposure effects (PAE). We also evaluated expression of genes associated with regulation of genes controlling expression of pro- and anti-inflammatory cytokines. Moreover, the objectives of our study included pharmacological correction of the observed changes by rifampicin (Rif), a potential pharmacological agent which had a neuroprotective effect shown by other studies,. The experimental model of PAE was produced by oral intake of 15% ethanol solution to pregnant female rats throughout pregnancy. The drug injections were performed to the pups from the 1 to the 7 postnatal days. Brain structures were sampled for gene expression analysis on the 8 postnatal day. The results of the study showed distinct changes in Tlr3 and Tlr4 gene expression in anterior and temporal lobes of brain on the 8 day of postnatal development. Expression of Myd88 and Ticam genes showed multidirectional changes among the studied brain structures of PAE rats. The increased mRNA level of proinflammatory genes was noted. Usage of Rif in experiments showed the ability of Rif (50 mg/kg) to correct the observed long-term pathological changes in the expression of the genes under study. It is of interest to study the dose-dependent effect in the future, as well as to investigate the revealed changes at the level of protein analysis. In future studies, it seems important to evaluate TLR signaling system in other brain structures with PAE, as well as at different terms of postnatal development in ontogenesis.
Study of the immunological efficacy and safety of a candidate vaccine against Lassa hemorrhagic fever
Authors: Popova O. , Zubkova O. V. , Ozharovskaia T. A. , Zrelkin D. I. , Voronina D. V. , Goldovskaya P. P. , Kan V. Yu. , Dolzhikova I. V. , Kovyrshina A. V. , Grousova D. M. , Ermolova I. A. , Shcheblyakov D. V. , Logunov D. Yu. , Gintsburg A. L.
Published: January 2025

Lassa hemorrhagic fever is an acute human infectious disease with high mortality rate and pandemic potential. To date, there are no approved drugs for the specific treatment or prevention of Lassa hemorrhagic fever in the world. The aim of this study was to develop and evaluate the immunobiological properties and preclinical safety of a candidate vaccine for the prevention of Lassa hemorrhagic fever (LHF) based on recombinant human adenoviral vectors. Standard genetic engineering techniques, molecular biology techniques, virological methods, and animal testing procedures were used in the course of the study. A combined vector candidate vaccine for the prevention of Lassa hemorrhagic fever has been designed and characterized. The vaccine is composed of two components for heterologous immunization in a prime-boost regimen. Both components are based on recombinant replication-defective adenovirus vectors. The first component of the vaccine is a recombinant human adenovirus type 26; the second component is a recombinant human adenovirus type 5. Both recombinant vectors contain the codon-optimized sequence of Lassa virus glycoprotein. Two experimental batches of the candidate vaccine were produced under GMP-conditions and analyzed. The results of studies in compliance with appropriate specifications for viral vector vaccines are provided. In preclinical studies in mice, antigen-specific IgG response was detected after immunization with two vaccine components, either separately, or in a prime-boost regimen. The time dynamics of the IgG response was also studied on 42, 77, 119 and 147 days after immunization. At the same time, despite achieving 100% seroconversion, no virus neutralizing antibodies were detected in any of the samples collected from immunized mice. A biodistribution study showed that 24 hours following intramuscular injection of the vaccine components, the DNA of adenovirus vectors was detected only at the site of injection and in regional lymph nodes. Based on preclinical safety assessments (including acute toxicity, chronic toxicity, immunotoxicity, allergenic properties, reproductive toxicity), no contraindications were found for initiation of the candidate Lassa vaccine clinical trials. Taken together, the results demonstrate that the candidate vaccine for prevention of Lassa hemorrhagic fever based on recombinant adenovirus vectors types 26 and 5 is a promising drug for specific immunoprophylaxis.
Use of plasmapheresis and intravenous immunoglobulins in pregnant women with antiphospholipid syndrome
Authors: Orlova E. S. , Chepanov S. V. , Zainulina M. S. , Selkov S. A.
Published: January 2025

Our objective was to demonstrate the efficiency of therapy for antiphospholipid syndrome (APS) in pregnant women using plasmapheresis and intravenous immunoglobulins.

92 women with diagnosed APS and 47 APS-free women with physiological pregnancy were under study. APS was diagnosed in accordance with Sydney Consensus Workshop (2006). Patients with APS were divided into groups depending on the method of treatment used: conventional therapy, plasmapheresis in addition to standard therapy, intravenous immunoglobulins (IVIG) in addition to standard therapy, and complex treatment, i.e., plasmapheresis and IVIG added to standard therapy. The levels of antiphospholipid antibodies, hemostasis parameters, P-selectin were measured in blood serum and plasma before and after treatment.

Higher frequency of favorable pregnancy outcomes was shown in the group of patients with APS who were treated with combined therapy, i.e. in 96.3% of cases (term birth). Frequency of prematurity and fetal hypotrophy was significantly lower in the group of patients with APS treated with combined therapy. The most significant decrease in the level of antiphospholipid antibodies was observed in the group treated by plasmapheresis, IVIG and conventional therapy. Expression of P-selectin in the women with normal pregnancy without antiphospholipid antibodies, was significantly lower compared to pregnant women with APS.

Usage of integrated approach using plasmapheresis, intravenous immunoglobulins and standard therapy is the most effective treatment for APS-related miscarriage. Implication of this strategy has reduced the incidence of obstetric complications and improved pregnancy outcomes due to increased frequency of term births, as well as lowest indices of pathology in the newborns. Analysis of P-selectin levels before and after treatment enables determination of the platelet activation levels, efficiency of therapeutic approaches, as well as medical drug correction of infavorable platelet hemostasis during therapy.
Germination dynamics of Neoglaziovia variegata (Arruda) Mez (Bromeliaceae): impact of thermal and saline thresholds on the ecology of the species
Authors: Gomes Raquel Araujo , Oliveira Williane Aparecida Silva , Ferreira Maria Aparecida Rodrigues , Silva Jailton de Jesus , Beckmann-Cavalcante Márkilla Zunete , Dantas Bárbara França
Published: January 2025

ABSTRACT: Global warming significantly impacts the environment, directly affecting plant development. Neoglaziovia variegata (Arruda) Mez is a Bromeliaceae endemic to the Caatinga, has highly resistant fibers used for income generation and has landscaping and medicinal potential. The study aimed to identify the thermal and saline thresholds that influence the germination of this species. In different experiments, the seeds were placed to germinate at constant temperatures between 15 and 40 °C and in substrate soaked in NaCl solution from 0 to 14 dS.m-1. The combination of thermal and salt stresses and the recovery of seeds after stress were also evaluated. All experiments followed a completely randomized design, with four replications of 25 seeds and lasted 28 days. The data were analyzed by thermal time and halotime models, establishing the thresholds for germination. The minimum and maximum temperatures for germination were 14.3 and 41.7 °C, respectively, with the ideal temperature of 31.1 °C. The germination threshold in saline medium was 16.2 dS.m-1. The seeds showed viability after being removed from the stress condition. The wide temperature range and high saline threshold show that the species can survive the most pessimistic climate change scenarios.
Prevenção do HIV e discriminação de gênero entre adolescentes travestis e mulheres trans em três capitais do Brasil no período 2019-2023
Authors: Leite Beo Oliveira , Magno Laio , Greco Dirceu , Grangeiro Alexandre , Dourado Ines
Published: January 2025

RESUMO Objetivo Descrever as práticas de prevenção do HIV e a discriminação de gênero entre adolescentes travestis e mulheres trans. Métodos Estudo transversal com 148 adolescentes travestis e mulheres trans de 15 a 19 anos de idade em Salvador, São Paulo e Belo Horizonte entre fevereiro/2019 e março/2023. Teste exato de Fisher foi utilizado para verificar diferenças entre práticas de prevenção e discriminação de gênero nos serviços de saúde. Resultados 18,9% relataram sexo anal com preservativo nos últimos 6 meses; 62,2% realizaram teste para o HIV alguma vez na vida; e 88,5% iniciaram a profilaxia pré-exposição (PrEP) ao HIV. As adolescentes entre 15 e 17 anos com experiências prévias de discriminação nos serviços haviam realizado menos testes de HIV na vida ou iniciaram menos a PrEP. Conclusão Ressalta-se a urgência para a implementação de políticas públicas que erradiquem a discriminação de gênero e ampliem o acesso à prevenção ao HIV.
Tuberculosis in the US Kidney Failure Population
Authors: Schildknecht Kimberly R. , Deutsch-Feldman Molly , Cummins Jason , Forbes Divia P. , Haddad Maryam B. , Apata Ibironke W. , Wortham Jonathan M.
Published: January 2025

Key Points

CKD is associated with a higher risk of tuberculosis.

We produced nationwide estimates of tuberculosis incidence and mortality associated with kidney failure.

Tuberculosis incidence ranged from 26.1 to 45.4 per 100,000 people with kidney failure, and nearly 40% died before diagnosis or during treatment.

Background

People with CKD have a higher risk of progression to tuberculosis disease after infection with Mycobacterium tuberculosis. We produced a nationwide incidence estimate and description of tuberculosis among people with kidney failure.

Methods

We completed a cross-sectional descriptive analysis of people with a reported case of tuberculosis in the United States between 2010 and 2021. We stratified all people with tuberculosis by reported kidney failure status. The primary outcome was tuberculosis incidence among people with kidney failure. We also compared characteristics of people with tuberculosis by reported kidney failure status.

Results

Approximately 3% of people (2892 of 111,155) diagnosed with tuberculosis between 2010 and 2021 also had kidney failure. Annual tuberculosis incidence ranged from 26.1 to 45.4 per 100,000 people with kidney failure and 2.1 to 3.5 per 100,000 people without kidney failure. Among people with kidney failure, 924 (32%) had extrapulmonary tuberculosis only and nearly 40% died: 286 were diagnosed with tuberculosis after death, and 792 died during treatment. People with tuberculosis and kidney failure had approximately twice the prevalence of a false-negative tuberculin skin test result (39%) compared with people with tuberculosis alone (20%).

Conclusions

Tuberculosis incidence among people with kidney failure between 2010 and 2021 in the United States was ten-fold that among people without kidney failure.
A INTERAÇÃO ENTRE UNIDADE HOSPITALAR E UNIVERSIDADE NO RETORNO FÍSICO FUNCIONAL DE INDIVÍDUOS PÓS-COVID-19
Authors: De Vargas Minuzzi Pietra , Freitas Lopes Luiza , Sodré Alves Rudimar , Medeiros Schmidt Patrícia , Tamborena Malheiros Rafael , Fioravanti Carpes Marta
Published: January 2025

Objetivo: identificar as características e as necessidades da população em questão e descrever os principais resultados encontrados através do vínculo entre unidade hospitalar e universidade, para o desenvolvimento de um ambulatório destinado ao atendimento de pacientes pós-Covid-19. Metodologia: para isso, de junho a dezembro de 2021, observamos o pós alta hospitalar de pacientes que permaneceram com sequelas físico funcionais decorrentes da Covid-19. Esses, após o consentimento, foram acolhidos no Ambulatório de Reabilitação Pós-Covid-19 e avaliados quanto a força muscular, dependência e desempenho funcional, para que assim recebessem a assistência fisioterapêutica necessária e individualizada. Resultados: foram atendidos 21 indivíduos com idades entre 33 e 74 anos, apresentando principalmente Hipertensão Arterial Sistêmica (HAS), Diabetes Mellitus (DM) e obesidade, com queixas como fadiga, fraqueza muscular e dispneia. O tempo médio de hospitalização foi de 31 dias, sendo que a maioria necessitou de Ventilação Mecânica Invasiva (VMI) e de bloqueadores neuromusculares. Dos avaliados, 8 indivíduos apresentaram independência funcional, mesmo apresentando maior dificuldade em realizar as atividades de vida diária após contraírem a Covid-19, 9 necessitavam de dispositivos auxiliares de marcha e 6 eram totalmente dependentes do auxílio de terceiros. As intervenções tinham como foco restabelecer o condicionamento cardiorrespiratório visando o retorno para as Atividades de Vida Diária, para isso foi realizado treinamento aeróbio, fortalecimento muscular, equilíbrio e flexibilidade, 3 vezes por semana com uma intensidade moderada. Conclusão: observamos que a interação entre Universidade e a atenção terciária foi essencial para o desenvolvimento de um processo intensivo de reabilitação, dando retorno à independência funcional dos indivíduos que ficaram hospitalizados por conta da Covid-19.
AVALIAÇÃO DA FREQUÊNCIA DO AJUSTE DE DOSE NA DISFUNÇÃO RENAL AGUDA E DOS CUSTOS EXCEDENTES DA ANTIBIOTICOTERAPIA EM UM HOSPITAL DE ENSINO
Authors: Ziemann Felipe , Inês Klinger Elisa , Portela Assis Mariana , Colombo Balbinot Fábio , Ziembowicz Henrique , Dagmar Pollo Renner Jane , Carneiro Marcelo , Mosmann Menezes Rochele
Published: January 2025

Objetivos: avaliar a frequência do ajuste de dose dos antimicrobianos frente a lesão renal aguda (LRA), os custos excedentes estimados com o uso destes medicamentos e o emprego da diálise durante o período de internação hospitalar. Metodologia: estudo transversal observacional, realizado com 30 pacientes de um hospital de ensino, que utilizaram antimicrobianos orais e parenterais, em concomitância com LRA, e com ajuste de dose previsto. Os dados referentes aos antimicrobianos prescritos e os custos envolvidos foram coletados do sistema informatizado do hospital. Para as análises estatísticas foram empregadas a média, desvio padrão e frequência absoluta. Resultados: os pacientes apresentaram idade média de 70,6 ±14 anos, sendo 13 pacientes do sexo masculino. Destes, três pacientes realizaram sessões de hemodiálise durante o período de internação. Dentre os antimicrobianos prescritos, 33 estavam em desacordo com a literatura empregada para análise das prescrições. Entre os tratamentos realizados, nove ultrapassam o tempo de tratamento preconizado pela equipe médica, variando entre um e três dias a mais de uso dos mesmos, conforme o antimicrobiano prescrito, gerando um custo excedente estimado com a antibioticoterapia de R$ 538,57.  Conclusão: os aspectos observados neste estudo, reforçam a importância do monitoramento das prescrições e do consumo dos antimicrobianos, principalmente entre a população idosa, evitando o uso de doses inadequadas, diante de alterações fisiológicas que possam estar presentes, do tempo de tratamento preconizado, com vistas a redução dos custos envolvidos e a otimização dos recursos disponíveis.
EFFECTIVENESS OF WHOLE BODY VIBRATION ON QUADRICEPS STRENGTH AND VERTICAL JUMP IN HEALTHY ATHLETES: a systematic review and meta-analysis
Authors: Moura Elaine Cristina Santa Cruz de , Oliveira Tatyane Gomes de , Cunha Beatriz Luiza Marinho , Marinho Patrícia Érika de Melo
Published: January 2025

Introduction: whole body vibration (WBV) is currently a training method increasingly used as an adjunct in sports to improve strength performance in various sports. Being a muscle training widely used for demanding sports practices of athletes who are physically well prepared for better performances. In addition, the literature shows that physical training with aerobic and resistance exercises promotes an improvement in the regenerative capacity of the athlete. However, the literature does not present systematic review studies on the effect of WBV on muscle strength in athletes.  Objective: This review and meta-analysis aimed to evaluate the effectiveness of WBV on muscle strength and vertical jump in healthy athletes. Method: A systematic review of randomized clinical trials which had used WBV compared to usual exercises in athletes of different modalities and having the assessment of muscle strength and vertical jump as outcomes. This study was conducted using PubMed/Medline, SciELO, LILACS, CINAHL and PEDro databases, without language or year restrictions. The search terms used were: ‘athletes’, ‘muscle strength’, ‘resistance training’, ‘muscle contraction’, ‘strength’, ‘clinical trial’ and ‘whole body vibration’. Risk of bias (RoB 2.0) and evidence quality (GRADE) were evaluated.  Results: Three clinical trials participated in the review, which presented a varied risk of bias and low quality of evidence. The WBV program for athletes increased muscle strength; however, no effects were verified for the vertical jump height. Conclusion: The studies evaluated in this review show that training with WBV was effective in increasing muscle strength in athletes, especially when associated with other conventional training; however, no changes were observed for the vertical jump height. The studies showed a variable risk of bias and low evidence quality.
RISCO CARDIOVASCULAR DE IDOSOS ATENDIDOS POR ESTUDANTES DE FISIOTERAPIA NA ATENÇÃO PRIMÁRIA A SAÚDE
Authors: Taís Eichstaedt Letícia , Da Rosa Rambo Tiago , Marília Reuter Éboni
Published: January 2025

Introdução: doenças cardiovasculares estão relacionadas ao envelhecimento e a Atenção Primária a Saúde atua sobre seus fatores de risco. O fisioterapeuta está inserido na Atenção Primária a Saúde contribuindo no manejo destes fatores, em que não está claro qual o perfil de risco cardiovascular de idosos que realizam fisioterapia. Objetivo: identificar o perfil de risco cardiovascular de idosos atendidos por estudantes de fisioterapia na Atenção Primária a Saúde. Métodos: estudo transversal realizado com 15 idosos de um município do interior do Rio Grande do Sul, avaliados por estudantes de fisioterapia de uma universidade comunitária quanto a medidas antropométricas (Índice de Massa Corporal e circunferência da cintura), hábitos (tabagismo e etilismo) e indicadores cardiovasculares (pressão arterial e Índice Tornozelo-Braquial), os quais foram utilizados para calcular o Escore de Risco Global. Os dados foram apresentados em frequência absoluta (número), medida de tendência central (mediana) e de dispersão (intervalo-interquartílico). A correlação entre variáveis numéricas foi testada utilizando o teste Rô de Spearman (p<0,05). Resultados: foi constatada presença de hipertensão arterial sistêmica (n=12), sobrepeso e obesidade abdominal (n=13 cada). A amostra foi classificada em totalidade com alto risco cardiovascular no Escore de Risco Global. Não houve correlação entre os valores de Índice Tornozelo-Braquial e a pontuação no Escore de Risco Global (r = 0,242; p = 0,385). Conclusão: idosos atendidos por estudantes de fisioterapia na rede de atenção primária a saúde apresentam fatores de risco cardiovascular e alto risco para desenvolverem doenças cardiovasculares no período de 10 anos.
Palavras-chave: Idoso; Doenças Cardiovasculares; Fisioterapia; Atenção Primária à Saúde.
(DES)CONHECIMENTOS DA POLÍTICA NACIONAL DE ATENÇÃO INTEGRAL LGBT ENTRE PROFISSIONAIS DE ENFERMAGEM E SEU IMPACTO NO CUIDADO DE MULHERES TRANS
Authors: Farias Silva Rita de Cássia , De Castro Sena Rômulo Mágnus , Duarte Fonseca Álvaro Micael , Da Silva Júnior José Antonio , Valente Silva Ysabele Yngrydh , De Góis Palmyra Sayonara , Gurgel Cosme do Nascimento Ellany
Published: January 2025

Introdução: A população LGBTQAI+, especialmente os sujeitos trans, enfrentam desafios no acesso à saúde devido a tensões sociais, violando a efetivação de direitos deste grupo social, apesar da existência de políticas públicas, como a Política Nacional de Atenção Integral de Lésbicas, Gays, Bissexuais, Travestis e Transexuais.  Objetivo: investigar como se dá a assistência de enfermagem às mulheres transexuais nas Unidades Básicas de Saúde, mediante o conhecimento da Política Nacional de Atenção Integral LGBT. Método: pesquisa qualitativa e exploratória, com profissionais de enfermagem de sete Unidades Básicas de Saúde. A coleta de dados ocorreu por entrevistas semiestruturadas, com sete enfermeiros. Os dados foram interpretados por meio da Análise de Conteúdo, se utilizando da técnica de análise temática. Resultados: os discursos manifestam conhecimento estigmatizado e preconceituoso sobre esta população, com conhecimento superficial e limitado sobre a Política Nacional de Saúde Integral LGBT e declararam a ausência de protocolos específicos para o atendimento de pessoas transexuais, em particular, mulheres trans. Conclusão: a assistência de enfermagem as mulheres trans é incipiente, concentrando-se principalmente na prevenção e tratamento de DSTs, desconsiderando outras necessidades dessa população e contribuindo para estigmatização. Há notável discriminação, evidenciada pela falta de compreensão das singularidades, desconhecimento de direitos e resistência em ajustar práticas que dificultam a aproximação com essa população.
Estimation of Areal Reduction Factors in South Africa, Part 2: Application and validation at catchment level
Authors: Pietersen J P J , Gericke O J , Smithers J C
Published: January 2025

Various empirical methods have evolved over the years in South Africa to estimate either design floods, design rainfall, catchment response time, and/or Areal Reduction Factors (ARFs). The verification of any empirical method requires the use of observed data not used during the calibration process, while observed data is also required for validation purposes. In the case of ARFs, which are used to convert average design point rainfall depths to an areal (catchment) design rainfall depth, all the calibration/verification data sets remain only estimated sample values of design rainfall. Subsequently, this paper presents an independent application and validation of the regional geographically-centred ARF method (Pietersen 2023) against the currently recommended geographically-centred ARF method (Alexander 2001) by incorporating the different ARF estimates into the Rational Method (RM) to highlight the impact thereof on the resulting flood estimates. In applying a ranking-based goodness-of-fit selection procedure, the RM in combination with the newly derived regional geographically-centred ARF method (Pietersen 2023) resulted in the best deterministic flood estimates when compared to the at-site statistical flood peaks. Apart from the ARFs, catchment response time, design rainfall, and weighted runoff coefficients are all regarded as key input parameters for design flood estimation in ungauged catchments.
Graded Slopes in Western Kansas
Authors: Frye John C.
Published: January 2025

Graded erosional slopes of several types occur in western Kansas. As these surfaces are developed on relatively nonresistant and uniform rocks they present particularly favorable conditions for study of their origin. They are described in three groups: (1) graded surfaces of the interfluves, judged to have developed prior to Illinoian time; (2) flanking pediments, controlled by the position of an adjacent stream course, that have developed during late Pleistocene time; and (3) "pedimented tributary" valleys or "concavo-convex" gullies that have developed since mid-Wisconsinan time. It is concluded that although lateral planation by minor streams may have been an important factor in the origin of the first category, the forms classed in the third category were cut by some form of surface sheet action of running water.
Petrography of Upper Permian Rocks in South-Central Kansas
Authors: Swineford Ada
Published: January 2025

Blanket-type deposits of post-Wolfcampian Permian age exposed in south-central Kansas constitute a northern part of the mid-continent Permian basin. They are restudied petrologically with reference to their composition, texture, structure, stratigraphy, and genesis.
The sediments are predominantly red in color, and consist of very fine-grained nonfossiliferous feldspathic sandstones and siltstones, silty shales and shales, and extensive thin evaporites. The detrital minerals of the sandstones and siltstones are primarily of igneous origin and are poorly rounded. The feldspars consist predominantly of orthoclase, with minor sodic plagioclase and microcline; they display various stages of weathering. The most common clay minerals are illite and chlorite, with montmorillonite in the upper part of the section.
The rocks are assigned to Krynine's tectonic arkose series but are far from their source areas and are intra-cratonal rather than postgeosynclinal in origin. These important differences are reflected chiefly in the clay mineralogy, average particle size, and shape and extent of the deposits.
The red color is due essentially to hematite stain on the mineral grains. The redbeds are classed with the primary detrital redbeds of Krynine, and the iron oxide is thought to have been transported as coatings on the detrital minerals and in colloidal solution from distant highlands, chiefly in Colorado and Oklahoma, having granitic terrane and humid tropical climate. The site of deposition is considered to have been a shallow restricted marine basin with deficient rainfall.
Present commercial use of the deposits is restricted essentially to the evaporites in the section: salt and gypsum. Some of the rocks formerly were used for building stone, common brick, and paint pigment. Some of the shale is potentially useful for ceramic aggregate and brown slip glaze.