bluuebunny/crossref_metadata_2025 huggingface dataset:
Progress in molecular feature of smoldering mantle cell lymphoma
Authors: Jiang Panruo , Desai Aakash , Ye Haige
Published: July 2021

Mantle cell lymphoma (MCL) is considered one of the most aggressive lymphoid tumors. However, it sometimes displays indolent behavior in patients and might not necessitate treatment at diagnosis; this has been described as “smoldering MCL” (SMCL). There are significant differences in the diagnosis, prognosis, molecular mechanisms and treatments of indolent MCL and classical MCL. In this review, we discuss the progress in understanding the molecular mechanism of indolent MCL to provide insights into the genomic nature of this entity. Reported findings of molecular features of indolent MCL include a low Ki-67 index, CD200 positivity, a low frequency of mutations in TP53, a lack of SOX11, normal arrangement and expression of MYC, IGHV mutations, differences from classical MCL by L-MCL16 assays and MCL35 assays, an unmutated P16 status, few defects in ATM, no NOTCH1/2 mutation, Amp 11q gene mutation, no chr9 deletion, microRNA upregulation/downregulation, and low expression of several genes that have been valued in recent years (SPEN, SMARCA4, RANBP2, KMT2C, NSD2, CARD11, FBXW7, BIRC3, KMT2D, CELSR3, TRAF2, MAP3K14, HNRNPH1, Del 9p and/or Del 9q, SP140 and PCDH10). Based on the above molecular characteristics, we may distinguish indolent MCL from classical MCL. If so, indolent MCL will not be overtreated, whereas the treatment of classical MCL will not be delayed.
MicroRNA-based signatures impacting clinical course and biology of ovarian cancer: a miRNOmics study
Authors: Krasniqi E. , Sacconi A. , Marinelli D. , Pizzuti L. , Mazzotta M. , Sergi D. , Capomolla E. , Donzelli S. , Carosi M. , Bagnato A. , Gamucci T. , Tomao S. , Natoli C. , Marchetti P. , Grassadonia A. , Tinari N. , De Tursi M. , Vizza E. , Ciliberto G. , Landi L. , Cappuzzo F. , Barba M. , Blandino G. , Vici P.
Published: July 2021

Background

In Western countries, ovarian cancer (OC) still represents the leading cause of gynecological cancer-related deaths, despite the remarkable gains in therapeutical options. Novel biomarkers of early diagnosis, prognosis definition and prediction of treatment outcomes are of pivotal importance. Prior studies have shown the potentials of micro-ribonucleic acids (miRNAs) as biomarkers for OC and other cancers.

Methods

We focused on the prognostic and/or predictive potential of miRNAs in OC by conducting a comprehensive array profiling of miRNA expression levels in ovarian tissue samples from 17 non-neoplastic controls, and 60 tumor samples from OC patients treated at the Regina Elena National Cancer Institute (IRE). A set of 54 miRNAs with differential expression in tumor versus normal samples (T/N-deregulated) was identified in the IRE cohort and validated against data from the Cancer Genoma Atlas (TCGA) related to 563 OC patients and 8 non-neoplastic controls. The prognostic/predictive role of the selected 54 biomarkers was tested in reference to survival endpoints and platinum resistance (P-res).

Results

In the IRE cohort, downregulation of the 2 miRNA-signature including miR-99a-5p and miR-320a held a negative prognostic relevance, while upregulation of miR-224-5p was predictive of less favorable event free survival (EFS) and P-res. Data from the TCGA showed that downregulation of 5 miRNAs, i.e., miR-150, miR-30d, miR-342, miR-424, and miR-502, was associated with more favorable EFS and overall survival outcomes, while miR-200a upregulation was predictive of P-res. The 9 miRNAs globally identified were all included into a single biologic signature, which was tested in enrichment analysis using predicted/validated miRNA target genes, followed by network representation of the miRNA-mRNA interactions.

Conclusions

Specific dysregulated microRNA sets in tumor tissue showed predictive/prognostic value in OC, and resulted in a promising biological signature for this disease.
A national study of choanal atresia in tertiary care centers in Canada – part II: Clinical management
Authors: Paradis Josee , Dzioba Agnieszka , El-Hakim Hamdy , Hong Paul , Kozak Frederick K. , Nguyen Lily H. P. , Perera Demitri , Propst Evan Jon , Siu Jennifer M. , Wojtera Monika , Husein Murad ,   National Choanal Atresia Study Working Group
Published: July 2021

Background

To evaluate the clinical management of choanal atresia (CA) in tertiary centers across Canada.

Methods

Multi-centre case series involving six tertiary care pediatric hospitals across Canada. Retrospective chart review of patients born between 1980 and 2010 diagnosed with choanal atresia to a participating center.

Results

The health charts of 215 patients (59.6% female) with choanal atresia (CA) were reviewed. Mean age of initial surgical repair was 0.8 months for bilateral CA, and 48.6 months for unilateral CA. Approaches of surgical repair consisted of endoscopic transnasal (31.7%), non-endoscopic transnasal (42.6%), and transpalatal (25.2%). Stents were used on 70.7% of patients. Forty-nine percent of patients were brought back to the OR for a planned second look; stent removal being the most common reason (86.4%). Surgical success rate of initial surgeries was 54.1%. Surgical technique was not associated with rate of restenosis [χ2 (2) = 1.6, p = .46].

Conclusions

The present study is the first national multi-institutional study exploring the surgical outcomes of CA over a 30-year period. The surgical repair of CA presents a challenge to otolaryngologists, as the rate of surgical failure is high. The optimal surgical approach, age at surgical repair, use of stents, surgical adjuncts, and need for planned second look warrant further investigation.

Graphical Abstract
The vertical structure of annual wave energy flux in the tropical Indian Ocean
Authors: Li Zimeng , Aiki Hidenori , Nagura Motoki , Ogata Tomomichi
Published: July 2021

A recently developed energy flux diagnosis scheme, which incorporates a smooth connection between the tropical and subtropical zones, is used in the present study to investigate vertically propagating waves in the tropical Indian Ocean (IO) based on the result of a linear, continuously stratified ocean model driven by climatological wind forcing. This extended diagnosis reveals deep-reaching eastward energy fluxes at the equator which develop four times per year and are associated with equatorial Kelvin waves (KWs) generated by semiannual winds. The authors find that the downward transfer of wave energy is particularly deep in the southern Bay of Bengal (SBoB). This downward flux is attributed to off-equatorial Rossby waves and appears four times per year, maximizing its amplitude during November–December. Southwesterly winds in the Arabian Sea intensify eastward energy flux of KWs at mid-depth, which maximizes in amplitude in August. This is contrastive to KW energy flux at the surface which peaks in May. These mid-depth equatorial KW packets subsequently arrive at the eastern boundary of the IO and are diffracted poleward to produce downward energy flux in November and December detected in the SBoB.
Fintech platforms: Lax or careful borrowers’ screening?
Authors: Gallo Serena
Published: July 2021

Can peer-to-peer lending platforms mitigate fraudulent behaviors? Or have lending players been acting similar to free-riders? This paper constructs a new proxy to investigate lending platform misconduct and compares the FICO score and the LendingClub credit grade. To examine whether the lack of verification by the Fintech platform affects lenders’ collection performance, I explore the recovery rate (RR) of non-performing loans through a mixed-continuous model. The regression results show that the degree of prudence taken by the lending platform in the pre-screening activity negatively affects the detection of some misreporting borrowers. I also find that the Fintech platform’s missing verification information (e.g., annual income and employment length) affects the RR of non-performing loans, thereby hampering lenders’ collection performance.
Peritoneal Dialysis Guidelines 2019 Part 1 (Position paper of the Japanese Society for Dialysis Therapy)
Authors: Ito Yasuhiko , Ryuzaki Munekazu , Sugiyama Hitoshi , Tomo Tadashi , Yamashita Akihiro C. , Ishikawa Yuichi , Ueda Atsushi , Kanazawa Yoshie , Kanno Yoshihiko , Itami Noritomo , Ito Minoru , Kawanishi Hideki , Nakayama Masaaki , Tsuruya Kazuhiko , Yokoi Hideki , Fukasawa Mizuya , Terawaki Hiroyuki , Nishiyama Kei , Hataya Hiroshi , Miura Kenichiro , Hamada Riku , Nakakura Hyogo , Hattori Motoshi , Yuasa Hidemichi , Nakamoto Hidetomo
Published: July 2021

Approximately 10 years have passed since the Peritoneal Dialysis Guidelines were formulated in 2009. Much evidence has been reported during the succeeding years, which were not taken into consideration in the previous guidelines, e.g., the next peritoneal dialysis PD trial of encapsulating peritoneal sclerosis (EPS) in Japan, the significance of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs), the effects of icodextrin solution, new developments in peritoneal pathology, and a new international recommendation on a proposal for exit-site management. It is essential to incorporate these new developments into the new clinical practice guidelines. Meanwhile, the process of creating such guidelines has changed dramatically worldwide and differs from the process of creating what were “clinical practice guides.” For this revision, we not only conducted systematic reviews using global standard methods but also decided to adopt a two-part structure to create a reference tool, which could be used widely by the society’s members attending a variety of patients. Through a working group consensus, it was decided that Part 1 would present conventional descriptions and Part 2 would pose clinical questions (CQs) in a systematic review format. Thus, Part 1 vastly covers PD that would satisfy the requirements of the members of the Japanese Society for Dialysis Therapy (JSDT). This article is the duplicated publication from the Japanese version of the guidelines and has been reproduced with permission from the JSDT.
Impact of Ivabradine on renal function in septic patient with early renal impairment
Authors: Sobhy Amr , Saleh Lobna A. , Shoukry Aktham Adel
Published: July 2021

Background

Acute kidney injury (AKI) with sepsis increases mortality significantly. The pathophysiology of AKI during sepsis is complex and multifactorial. Lower heart rate is associated with better survival in patients with multiple organ dysfunction syndrome (MODS), a disease mostly caused by sepsis. In our study, we hypnotized that use of ivardrabine as heart rate reducing agent in septic patient with renal impairment may improve renal function.

Results

Fifty patients with sepsis with early renal impairment were divided in 1: 1 ratio to receive Ivabradine (group I) or not (group C). The average age of the included patients was almost 45 years, chest disorders were the main cause of sepsis in both groups. There were statistically significant differences between both groups in terms of reduction of heart rate group (I) (68.13 ± 3.34) versus (group C) (87.04 ± 3.23) and (P < 0.001) also, improvement in eGFR by Cystatin c in group (I) (103.32 ± 6.96) versus (group C) (96.25 ± 6.36) and (P < 0.001) also vasopressor dosage consumption (P < 0.001). As regards secondary outcomes, there were no statistically significant differences between study’s groups in terms of length of hospital stay (P = 0.390), need for hemodialysis (P = 0.384), and mortality (P = 1.000).

Conclusions

We concluded that Ivabradine as an adjuvant therapy in septic patients with renal impairment is promising agent to reduce such impairment.

Trial registration

Pan African Clinical Trial Registry: Identification number for the registry is PACTR201911806644230.
Ultrasound-guided lumbar ESP block for post-operative analgesia as an alternative mode of analgesia in hip arthroplasty with multiple systemic issues: a case report
Authors: Mujahid Omer Mohammed , Dey Samarjit , Nagalikar Suresh , Arora Prateek , Dey Chandan Kumar
Published: July 2021

Background

Patients with multiple systemic diseases present an anaesthetic challenge in terms of perioperative pain management. We propose that ultrasound-guided erector spinae plane block be used as an alternative mode of analgesia in patients undergoing hip arthroplasty.

Case presentation

We report a case of a 54-year-old female, a known case of autosomal dominant polycystic kidney disease on continuous ambulatory peritoneal dialysis, hypertension, and deranged coagulation profile with fractured neck of femur planned for hemiarthroplasty. She was administered ultrasound-guided single-shot erector spinae plane block at L3 level with 20 mL of 0.25% ropivacaine and 4 mg dexamethasone. This block provided excellent post-operative analgesia for up to 24 h with early mobilisation.

Conclusion

Single-shot ultrasound-guided erector spinae plane bock can be used as an alternative mode of analgesia in patients undergoing hip arthroplasty, with multiple systemic diseases in whom neuraxial blockade cannot be performed. This technique needs to be further explored in the form of randomised controlled trials.
Nutritional status of multiple sclerosis (MS) patients attending Kasr Alainy MS unit: an exploratory cross-sectional study
Authors: Afifi Zeinab E. , Shehata Rania I. , El Sayed Asmaa F. , Hammad El Sayed M. , Salem Marwa R.
Published: July 2021

Background

Nutrition was claimed to be a factor in MS causation, course, complications, and management. Several studies were conducted to assess the nutritional status of MS patients; however, few studies were conducted to assess this problem in Egypt. Therefore, the purpose of the current study was to assess the nutritional status of a sample of MS patients.

Methods

The researchers conducted an exploratory cross-sectional study among 76 relapsing-remitting MS (RRMS) patients attending Kasr Alainy Multiple Sclerosis Unit (KAMSU) from October 2018 to January 2019 to assess the nutritional status of a sample of MS patients. Data were collected using a structured interview questionnaire including an inquiry about the socioeconomic status, and nutritional status using anthropometric measurements, patient-generated subjective global assessment (PG-SGA), semi-quantitative food frequency questionnaires (SQFFQ), and hemoglobin level measurement. Assessment of fatigue was done using the Modified Fatigue Impact Scale 5-items version.

Results

The mean age of the study participants was 30 ± 6 years. The disease duration ranged from 2 to 264 months. Malnutrition was prevalent among 67.1% (27.6 % overweight, 36.8% obese, and 2.6% underweight). Half of the investigated patients were anemic. According to the PG-SGA, more than half of the studied patients (53.9%) were classified as moderately or suspected malnourished. The unhealthy dietary habits such as taking only a few meals, junk food intake and skipping breakfast were observed in considerable proportions of the group. The SQFFQ revealed overconsumption of energy and fat, and less than acceptable consumption of dietary fibers by most of the studied patients.

Conclusions

Overweight, obesity, anemia, and unhealthy dietary habits were prevalent among the RRMS patients attending the KAMSU. Nutrition care service is extremely needed for this group of patients.
Nomenclatural issues concerning cultured yeasts and other fungi: why it is important to avoid unneeded name changes
Authors: Yurkov Andrey , Alves Artur , Bai Feng-Yan , Boundy-Mills Kyria , Buzzini Pietro , Čadež Neža , Cardinali Gianluigi , Casaregola Serge , Chaturvedi Vishnu , Collin Valérie , Fell Jack W. , Girard Victoria , Groenewald Marizeth , Hagen Ferry , Hittinger Chris Todd , Kachalkin Aleksey V. , Kostrzewa Markus , Kouvelis Vassili , Libkind Diego , Liu Xinzhan , Maier Thomas , Meyer Wieland , Péter Gábor , Piątek Marcin , Robert Vincent , Rosa Carlos A. , Sampaio Jose Paulo , Sipiczki Matthias , Stadler Marc , Sugita Takashi , Sugiyama Junta , Takagi Hiroshi , Takashima Masako , Turchetti Benedetta , Wang Qi-Ming , Boekhout Teun
Published: July 2021

The unambiguous application of fungal names is important to communicate scientific findings. Names are critical for (clinical) diagnostics, legal compliance, and regulatory controls, such as biosafety, food security, quarantine regulations, and industrial applications. Consequently, the stability of the taxonomic system and the traceability of nomenclatural changes is crucial for a broad range of users and taxonomists. The unambiguous application of names is assured by the preservation of nomenclatural history and the physical organisms representing a name. Fungi are extremely diverse in terms of ecology, lifestyle, and methods of study. Predominantly unicellular fungi known as yeasts are usually investigated as living cultures. Methods to characterize yeasts include physiological (growth) tests and experiments to induce a sexual morph; both methods require viable cultures. Thus, the preservation and availability of viable reference cultures are important, and cultures representing reference material are cited in species descriptions. Historical surveys revealed drawbacks and inconsistencies between past practices and modern requirements as stated in the International Code of Nomenclature for Algae, Fungi, and Plants (ICNafp). Improper typification of yeasts is a common problem, resulting in a large number invalid yeast species names. With this opinion letter, we address the problem that culturable microorganisms, notably some fungi and algae, require specific provisions under the ICNafp. We use yeasts as a prominent example of fungi known from cultures. But viable type material is important not only for yeasts, but also for other cultivable Fungi that are characterized by particular morphological structures (a specific type of spores), growth properties, and secondary metabolites. We summarize potential proposals which, in our opinion, will improve the stability of fungal names, in particular by protecting those names for which the reference material can be traced back to the original isolate.
Comparison of post-operative three-dimensional and two-dimensional evaluation of component position for total knee arthroplasty
Authors: Tanifuji Osamu , Mochizuki Tomoharu , Yamagiwa Hiroshi , Sato Takashi , Watanabe Satoshi , Hijikata Hiroki , Kawashima Hiroyuki
Published: July 2021

Purpose

The purpose of this study was to evaluate the post-operative three-dimensional (3D) femoral and tibial component positions in total knee arthroplasty (TKA) by the same co-ordinates’ system as for pre-operative planning and to compare it with a two-dimensional (2D) evaluation.

Materials and methods

Sixty-five primary TKAs due to osteoarthritis were included. A computed tomography (CT) scan of the femur and tibia was obtained and pre-operative 3D planning was performed. Then, 3D and 2D post-operative evaluations of the component positions were performed. KneeCAS (LEXI, Inc., Tokyo, Japan), a lower-extremity alignment assessment system, was used for the 3D post-operative evaluation. Standard short-knee radiographs were used for the 2D post-operative evaluation. Differences between the pre-operative planning and post-operative coronal and sagittal alignment of components were investigated and compared with the results of the 3D and 2D evaluations.

Results

According to the 3D evaluation, the difference between the pre-operative planning and actual post-operative sagittal alignment of the femoral component and the coronal and sagittal alignments of the tibial component were 2.6° ± 1.8°, 2.2° ± 1.8° and 3.2° ± 2.4°, respectively. Using the 2D evaluation, they were 1.9° ± 1.5°, 1.3° ± 1.2° and 1.8° ± 1.4°, making the difference in 3D evaluation significantly higher (p = 0.013, = 0.003 and < 0.001). For the sagittal alignment of the femoral component and the coronal and sagittal alignment of the tibial component, the outlier (> ± 3°) ratio for the 3D evaluation was also significantly higher than that of the 2D evaluation (p < 0.001, = 0.009 and < 0.001).

Conclusions

The difference between the pre-operative planning and post-operative component alignment in the 3D evaluation is significantly higher than that of the 2D, even if the same cases have been evaluated. Two-dimensional evaluation may mask or underestimate the post-operative implant malposition. Three-dimensional evaluation using the same co-ordinates’ system as for pre-operative planning is necessary to accurately evaluate the post-operative component position.
Oncology Medical Home: ASCO and COA Standards
Authors: Woofter Kim , Kennedy Erin B. , Adelson Kerin , Bowman Ronda , Brodie Rachel , Dickson Natalie , Gerber Rose , Fields Karen K. , Murtaugh Carol , Polite Blase , Paschall Marcus , Skelton Matthew , Zoet Dennis , Cox John V.
Published: July 2021

PURPOSE:

To provide Standards on the basis of evidence and expert consensus for a pilot of the Oncology Medical Home (OMH) certification program. The OMH model is a system of care delivery that features coordinated, efficient, accessible, and evidence-based care and includes a process for measurement of outcomes to facilitate continuous quality improvement. The OMH pilot is intended to inform further refinement of Standards for OMH model implementation.

METHODS:

An Expert Panel was formed, and a systematic review of the literature on the topics of OMH, clinical pathways, and survivorship care plans was performed using PubMed and Google Scholar. Using this evidence base and an informal consensus process, the Expert Panel developed a set of OMH Standards. Public comments were solicited and considered in preparation of the final manuscript.

RESULTS:

Three comparative peer-reviewed studies of OMH met the inclusion criteria. In addition, the results from 16 studies of clinical pathways and one systematic review of survivorship care plans informed the evidence review. Limitations of the evidence base included the small number of studies of OMH and lack of longer-term outcomes data. More data were available to inform the specific Standards for pathways and survivorship care; however, outcomes were mixed for the latter intervention. The Expert Panel concluded that in the future, practices should be encouraged to publish the results of OMH interventions in peer-reviewed journals to improve the evidence base.

STANDARDS:

Standards are provided for OMH in the areas of patient engagement, availability and access to care, evidence-based medicine, equitable and comprehensive team-based care, quality improvement, goals of care, palliative and end-of-life care discussions, and chemotherapy safety. Additional information, including a Standards implementation manual, is available at www.asco.org/standards .
TRP channels in health and disease at a glance
Authors: Yue Lixia , Xu Haoxing
Published: July 2021

The transient receptor potential (TRP) channel superfamily consists of a large group of non-selective cation channels that serve as cellular sensors for a wide spectrum of physical and environmental stimuli. The 28 mammalian TRPs, categorized into six subfamilies, including TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin) and TRPP (polycystin), are widely expressed in different cells and tissues. TRPs exhibit a variety of unique features that not only distinguish them from other superfamilies of ion channels, but also confer diverse physiological functions. Located at the plasma membrane or in the membranes of intracellular organelles, TRPs are the cellular safeguards that sense various cell stresses and environmental stimuli and translate this information into responses at the organismal level. Loss- or gain-of-function mutations of TRPs cause inherited diseases and pathologies in different physiological systems, whereas up- or down-regulation of TRPs is associated with acquired human disorders. In this Cell Science at a Glance article and the accompanying poster, we briefly summarize the history of the discovery of TRPs, their unique features, recent advances in the understanding of TRP activation mechanisms, the structural basis of TRP Ca2+ selectivity and ligand binding, as well as potential roles in mammalian physiology and pathology.
Metabolic rates of aggressive and submissive phenotypes are colour blind in the polymorphic Gouldian finch
Authors: Buttemer William A. , Careau Vincent , Chappell Mark A. , Griffith Simon C.
Published: July 2021

Evidence from a number of species suggests that behaviours associated with social rank are positively correlated with metabolic rate. These studies, however, are based on metabolic measurements of isolated individuals, thereby ignoring potential effects of social interactions on metabolic rates. Here, we characterised three pertinent metabolic indices in the two predominant genetic colour morphs of the Gouldian finch (Erythrura gouldiae): diurnal resting metabolic rate (RMR), nocturnal basal metabolic rate (BMR) and exercise-induced maximal metabolic rate (MMR). Research reveals that red-headed morphs consistently dominate the less aggressive black-headed morphs and that the two morphs differ in other behavioural and physiological traits. We measured daytime RMR of intermorph naïve birds (first-year virgin males maintained in total isolation from opposite colour morphs) and their metabolic responses to viewing a socially unfamiliar bird of each colour. Subsequently, each bird was placed in a home cage with an opposite colour morph (intermorph exposed) and the series of measurements was repeated. Daytime RMR was indistinguishable between the two morphs, regardless of whether they were intermorph naïve or intermorph exposed. However, both red- and black-headed birds showed a greater short-term increase in metabolic rate when viewing an unfamiliar red-headed bird than when seeing a black-headed bird, but only when intermorph naïve. Measurements of BMR and exercise-induced MMR did not differ between the two morphs, and consequently, aerobic scope was indistinguishable between them. We propose that the behavioural differences between these two sympatric morphs are functionally complementary and represent evolutionary stable strategies permitting establishment of dominance status in the absence of metabolic costs.
Gasified boiler units
Authors: Kuznecov Vyacheslav , Bryuhanov Oleg
Published: July 2021

The textbook gives the basic concepts of gasified heat generating (boiler) installations and the terminology used in boiler technology, the principle of operation and device of gasified heat generating (boiler) installations. The types and device of heat generators (boilers) of their furnace devices are considered; types and device of gas-burning devices, the number and places of their installation in furnace devices; auxiliary equipment-devices for air supply and removal of combustion products, devices for water treatment, steam supply and circulation of the coolant of hot water boilers; device for thermal control and automatic regulation of the boiler installation. The issues of operation and efficiency of gasified heat generating (boiler) installations and their gas supply systems; requirements for conducting gas-hazardous and emergency recovery operations of gas supply systems are considered.
Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation.
For students of secondary vocational education in the specialty 08.02.08 "Installation and operation of equipment and gas supply systems".
Accounting
Authors: Burmistrova Lyudmila
Published: July 2021

the textbook reveals the basics of accounting and reporting. This knowledge will help economists and managers to better understand the work of accountants, quickly and carefully make management decisions based on the processes occurring in the organization's finances.
It contains the most important concepts and definitions. Raises the main problems related to the organization and maintenance of accounting, reporting, financial management based on analysis and management accounting. In addition, the issues of taxes and tax accounting at the enterprise were touched upon.
The material is presented in an accessible language, with examples and calculations. The methods of accounting and analysis are given. With the help of control questions, tests, tasks, the skills of reflecting business operations in the accounting and financial analysis system are fixed.
For students and teachers, as well as anyone interested in accounting issues.
Gender psychology
Authors: Semenova Vera
Published: July 2021

The textbook reveals the main range of issues of a new branch of psychological science — gender psychology. It is based on the author's lecture course, which has been read to psychology students for many years.
The textbook is structured in such a way that students can master the most important concepts and provisions of the gender approach, which forms the theoretical and methodological basis of gender psychology, its subject, as well as the skills of gender analysis of social reality and the psyche of a modern person. The article presents the problems reflecting the structure of gender psychology, supplemented by the presentation of some socio-psychological aspects of human sexuality.
The theoretical material is illustrated by various examples. At the end of each chapter, there are questions and tasks that allow you to better understand the content.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is aimed at bachelor students studying in the field of training 37.03.01 "Psychology" of all profiles, teachers of psychological faculties, as well as specialists in the field of academic and practical psychology.
Technical means of informatization
Authors: Gagarina Larisa , Zolotuhin Filipp
Published: July 2021

The systematization of the main structural elements of computers and computer equipment is given, the principles of their operation and the features of their functioning are described. The methods of modernization and debugging are considered. The issues of compatibility, configuration and rational use of equipment are analyzed.
Meets the requirements of the federal state educational standards of secondary vocational education of the latest generation.
For students, postgraduates, researchers, teachers of higher and secondary vocational educational institutions, as well as for everyone interested in the device of a personal computer.
Anti-crisis management
Authors: Orehov Vladimir , Orehova Tat'yana , Baldin Konstantin
Published: July 2021

The anti-crisis management of the economy and national security of the Russian Federation in modern conditions (pandemics, hybrid wars, competitive restrictions and anti-Russian propaganda from the West), approaches to Western sanctions as new opportunities for the development of the Russian Federation are considered. The ways of developing an innovative economy and increasing the productivity of aggregate labor as the main sources that ensure the accelerated development of the country are outlined. Attention is paid to the peculiarities of social partnership, economic and financial crises in the trends of macro - and micro-development, the role of investment as a financial source of anti-crisis management. The theoretical and practical foundations of the insolvency (bankruptcy) of enterprises and individual entrepreneurs, the methodology of the enterprise's recovery from the crisis, forecasting the results of anti-crisis management are described.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For undergraduate, graduate, postgraduate students and teachers of higher educational institutions of economic specialties, as well as researchers, managers and managers of firms.
Analysis of legal regulation and judicial practice of resolving disputes between parents about children
Authors: Dergunova Viktoriya , Prokopova Anastasiya
Published: July 2021

The monograph is a comprehensive study of the current practice of resolving cases on determining the place of residence of children, the procedure for communicating with them separately living parents and other relatives; restriction and deprivation of parental rights; on the departure of children outside the Russian Federation and return within the framework of the Convention on Civil Aspects of International Child Abduction of 1980, the Convention on Jurisdiction, Applicable Law, Recognition and Enforcement and Cooperation in relation to Parental Responsibility and Measures for the Protection of children of 1996.The relations that develop between the child and parents, the child and the court, parents and the court, as well as parents as parties to the process are analyzed. The central place is occupied by the study of the content of the concept of the best interests of the child as a guarantee of the protection of his rights and the vector of development of the current legislation. The cases of abuse of parental rights and improper performance (or non-performance) of parental duties, illustrated by current judicial practice, are considered. The analysis is presented: measures of family legal responsibility, including restriction and deprivation of parental rights in connection with non-execution of a court decision on the upbringing of a child; features of the application of principle 6 of the Declaration of the Rights of the Child in resolving disputes about the place of residence of children; the possibility of taking interim measures in disputes between parents about upbringing; the ratio of legal and psychological categories in child-parent relations in order to apply special knowledge; the procedure for conducting forensic examinations in these categories of cases. Finally, the possibilities of out-of-court settlement of some family disputes, including through mediation, are investigated.
For a wide range of readers interested in the rights of the child. It will be useful for students, postgraduates and teachers of law schools.
Finance and Financial analysis
Authors: Minobrnauki Rossiyskoy
Published: July 2021

The textbook systematizes basic knowledge in the field of finance, financial analysis and financial management, presented in their direct relationship and significance from the point of view of evaluation, diagnosis, forecasting and monitoring of the continuity of the organization's activities. It includes seven chapters grouped into three sections. The first section is devoted to the theoretical foundations of the organization's financial management, stakeholders and sources of the organization's activities. The second section discusses the basics of financial analysis, providing knowledge of the main directions, information base and methods of financial analysis, as well as allowing them to be applied reasonably, calculate and evaluate analytical indicators, determine the impact of globalization processes, various macro-and microfactors on the financial condition of the organization. The third section contains the basics of financial management, providing an understanding of the essence of the financial mechanism of the organization and algorithms for justifying decisions in the field of financial management.
It complies with the federal state educational standards of higher education of the latest generation and provides the formation of basic competencies in the field of finance, financial management and financial analysis.
For bachelor's, specialist's and master's students studying in the field of Economics, the system of additional professional education, training centers for advanced training of auditors and other financial market specialists, as well as for individual preparation of applicants for qualification certification and passing qualification exams.
The struggle for Eurasia in the focus of transport geostrategies
Authors: Harlamova Yuliya
Published: July 2021

The monograph examines the problems that play an important role in the processes of constructing transport geostrategies on the Eurasian continent. In the processes of redrawing the world's spaces, the transport sphere (along with financial and information) often acts as a catalyst for modern transformations. It is emphasized that thanks to transport networks, the economy on a global scale is structured in a completely specific way. To increase the potential of any state and society (the peoples living in it), the creation of conditions for communication community (in the broadest sense) is an integral component of its sustainability. The thesis is proved that the direction of the flow of many global integration or disintegration processes corresponding to the new world conditions depends on the reliable and fast operation of transport communications. Special attention is paid to the concept of the modern Chinese state "One Belt , One Road", which the Chinese elite actively promotes in the external space. Some aspects of the economic and transport development of the Arctic region in the context of the functioning of the Northern Sea Route are considered. Due attention is paid to the special role of Central Asia in the context of these problems, as well as the implementation of the international transport project "North - South".
For students and teachers, as well as for anyone interested in economics and politics.
The concept of a digital state and a digital legal environment
Authors: Pashencev Dmitriy , Dorskaya Aleksandra , Zaloilo Maksim
Published: July 2021

The development of digital technologies, large-scale digitalization that has covered all advanced countries, the entry of states into the era of the sixth technological order lead to significant changes in the state itself, its structure and functions. The monograph reveals the fundamental transformations of the modern state under the influence of the digital and technological vector of its development.
Special attention is paid to qualitative technological changes in the main areas of state activity, the processes of creating legal norms (law-making) and their practical implementation (legal realization).
The digital state emerging under the influence of new technologies acts as a theoretical model of the state of the future. Going beyond the strict scientific rationality in its classical sense allowed us to study the post-modern state, the phenomenon of which is increasingly becoming a reality and is embodied through the digital legal environment.
For scientists, practitioners of public authorities, graduate students, students of law faculties.
Consumer protection
Authors: Shuvalova Irina
Published: July 2021

The textbook has been prepared taking into account the current state of legislation and the practice of its application. The main concepts and categories in the field of consumer protection are considered, specific examples are given, practical recommendations are given.
It contains samples of documents: claims, statements, complaints, petitions, statements of claim, etc. on various issues in the field of consumer protection.
It is intended for students, practitioners, as well as anyone interested in consumer protection issues.
Administrative law and administrative responsibility
Authors: Rossinskiy Boris
Published: July 2021

The course of lectures corresponds to the programs of administrative law for students studying in the bachelor's degree program "Jurisprudence", as well as the specialties" Legal support of national security "and"Law Enforcement".
The course of lectures summarizes the author's experience of lecturing on administrative law and administrative responsibility at the All-Russian State University of Justice (RPA of the Ministry of Justice of Russia),
the Moscow University of the Ministry of Internal Affairs of Russia, the Academy of the Investigative Committee of the Russian Federation, and a number of other universities.
For students, cadets, postgraduates, adjuncts and teachers of law schools and faculties, researchers, employees of state and municipal bodies, persons improving their qualifications.
CAD programming: Spatial modeling of a column apparatus in the Autodesk Inventor environment
Authors: Lyang Viktor
Published: July 2021

The tutorial describes in detail the creation of an external subsystem for Autodesk Inventor in the high-level language C# Microsoft Visual Studio of the column apparatus. Such issues as working in the Microsoft Visual Studio 2010 programming environment, connecting the library of functions of the Autodesk Inventor API to an external user subsystem, spatial solid-state modeling of elements of a column apparatus, saving constructed objects, assembling the apparatus from stored modules by the interface method of surfaces are considered.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the direction of "Computer Science and computer engineering", in preparation for laboratory work and the exam. It can be used by students of other specialties when studying the courses "Fundamentals of Computer Science", "High-level programming language" and "3D modeling of machines and apparatuses". It may be useful for programmers engaged in spatial modeling of objects.
Tumult i konfederacja
Authors: Kucharski Adam
Published: July 2021

The Tumult and Confederation: Religious Significance of the Toruń 1724 and 1767 Events in the Light of Contemporary Manuscript Newsbooks

In the eighteenth century, the town of Toruń, which was politically, religiously, and demographically dominated by Protestants, became twice the nucleus of a countrywide rebellion. The first insurgency occurred in 1724, when the town became the place of religious riots known as the Toruń tumult. The second rebellion appeared in the form of the dissident Crown Confederation of Toruń in 1767, which was founded in response to a Catholic confederation organized in Radom. Both incidents had meaningful impact on the overall situation in Poland-Lithuania. One can find information on these disturbances in contemporary political writings and press. In particular, we find interesting opinions about the Toruń tumult in handwritten newspapers, the only source of news in the Polish territory before the establishment of the first printed newspaper in 1729.
The challenge of treating chronic pain in inflammatory bowel disease
Authors: Bakshi Nikul , Berry Sarah , Aziz Qasim , Glatter Jackie
Published: July 2021

Many patients with inflammatory bowel disease experience chronic pain, even after their inflammation is controlled. This article discusses the barriers and actions required for effective pain management.
Facial pigmentation and melasma reduction using a hydroquinone- and tretinoin-based skin transformation system
Authors: Bawa Manav
Published: July 2021

Many patients present to clinics with hyperpigmentation and melasma, and a hydroquinone/tretinoin-based skin system can be an effective treatment. The author presents two case studies in this article: one is related to a 50-year-old patient with melasma on her cheeks and the other, to a 40-year-old patient who presented with pigmentation. Both patients had these conditions for many years and had used numerous products in the past with no success. The melasma and pigmentation had a huge impact on their daily life, and, after thorough consultations, they used the Obagi Nu Derm Transformation System® with tretinoin. This article will describe a hydroquinone- and tretinoin-based system and some of the results achieved.
New to entrepreneurship? Part 3: building your brand's culture
Authors: Ratcliffe Jason
Published: July 2021

In the third part of this series, Jason Ratcliffe details the role of the team in building an aesthetic clinic's brand and how important it is to have a culture within the business
On the question of diversity: equality in the workplace
Authors: Bernstein Adam
Published: July 2021

Adam Bernstein, in collaboration with Helen Mitchell, Tom Neil and Emma Kearns, details the steps that employers can take towards a more equal workplace and why neurodivergent people should be hired
In vitro Cytotoxic Potential of Alkaloid and Flavonoid Rich Fractions of Alseodaphne semecarpifolia Against MCF-7 Cells
Authors: Chethankumara Ganadhal Puttaramaiah , Nagaraj Kakanahalli , Krishna Venkatarangaiah
Published: July 2021

The stem bark and leaves of A. semecarpifolia (Lauraceae) have been employed by traditional healers in Western Ghats region of Karnataka, India to treat human breast cancer. The present study was initiated to explore the cytotoxic properties of A. semecarpifolia. The secondary metabolites were extracted from stem bark and leaves. The stem bark methanol extract (SBME) and leaf methanol extract (LME) were subjected to liquid-liquid partition chromatography, followed by evaluating the presence of phytochemical constituents in liquid fractions and their cytotoxic potential against MCF-7 and L6 cells by MTT assay. The qualitative phytochemical screening of theliquid fractions revealed the presence of different secondary metabolites. The quantitative analysis revealed that the liquid fractions were rich in alkaloids, flavonoids and phenolic compounds. Stem bark methanol fraction (SBMF) and leaf methanol fraction(LMF) showed potential cytotoxicity on MCF-7 cells with an IC50 of 47.11±3.53µg/ml and 48.62±2.40µg/ml respectively. Whereas, stem bark chloroform fraction(SBCF) and leaf chloroform fraction(LCF) showed moderate activity on MCF-7 cells. Vinblastine sulphate was used as a reference standard and it showed potent cytotoxic activity against MCF-7 cells with an IC50 of 24.03±2.12µg/ml. Even though Vinblastine is a potentchemotherapeutic drug it affected the viability of normal cells. In comparison with Vinblastine, the liquid fractions showed very less toxicity on normal cells. Hence, the present study suggested that A. semecarpifolia stem bark and leaves are the potent cytotoxic agents against MCF-7 cells.