bluuebunny/crossref_metadata_2025 huggingface dataset:
Apexificación en incisivos centrales superiores con Biodentine
Authors: González Yaguana Jhannder Jhon , González Eras Susana Patricia , Barragán Ordoñez Andrés Eugenio , Carrión Sarmiento Marco Vinicio
Published: December 2021

La presente investigación corresponde a una revisión bibliográfica de tipo cualitativa, descriptiva y documental, el estudio fue realizado mediante criterios de exclusión e inclusión, para ello fueron analizados varios artículos científicos basados en apexificación, los cuales tuvieron como objetivo determinar la eficacia del Biodentine en la formación del cierre apical en los incisivos centrales superiores permanentes, además de identificar las propiedades de este material en relación con las estructuras dentales. El análisis utilizado fueron 26 artículos de tipo documental desde el año 2014 hasta el año 2020, revisiones bibliográficas, casos clínicos, los cuales fueron organizados en tablas diseñadas para el efecto. La apexificación la analizamos como un proceso que nos permite crear un ambiente dentro del conducto radicular y los tejidos periapicales luego de que se dé la muerte pulpar, lo cual permite la formación de una barrera calcifica a través del ápice abierto. Él Biodentine es un cemento de silicato de calcio que posee propiedades biocompatible y de bioactividad que al entrar en contacto directo con el tejido pulpar, induce al desarrollo de dentina reparativa lo cual logra mantener la vitalidad y función del tejido. Además, en relación con las estructuras dentales, la apexificación con Biodentine permite un sellado hermético de los túbulos dentinarios en dientes permanentes jóvenes, manteniendo las condiciones óptimas y correcto sellado apical.
EFFECTS OF DREDGING ON DOWNSTREAM WATER QUALITY: EKOLE CREEK, NIGERIA
Authors: Ogunlowo Opololaoluwa Oladimarum , Simon Churchill Ebinimitei
Published: December 2021

Water is essential part of ecosystem, so its quality must be ascertained for use especially in Ekole creek of Nigeria where dredging activities is heavy, hence this study examined the dredging effect on the downstream water quality of Ekole creek. Water samples were collected from four points which are; Upstream, Dredge I, Dredge II, and Downstream points. The parameters of the water quality determined showed that Turbidity and Total Suspended Solids (TSS) were higher at the Downstream point with values of 31 NTU and 1664 mg/l respectively; pH was also slightly acidic (6.61); but low in Total Dissolve Solid (TDS), Electrical Conductivity,  Nitrate (NO3) and Dissolved Oxygen (DO), as compare to the Upstream. The values of the  heavy metals like Pb (3.845 mg/l), Cr (0.612 mg/l) Ni (0.104 mg/l) and Cu (0.128 mg/l),  at Downstream point, were above Pb (3.0605 mg/l), Cr (0.0 mg/l), Ni (0.017 mg/l) and Cu (0.102 mg/l) of  the Upstream point,before the Dredging points I and II, that have  correlative matrix of(Pb>Fe>Mn>Zn>Cu>Ni>Cr) and  Pb>Fe>Cr>Mn>Zn>Cu>Ni Downstream point. Is discovered the Downstream water is slightly acidic, high in Turbidity and TSS, but low in TDS, EC, NO3 and DO, as against the WHO drinking-water quality, due the effect of dredging on the water quality of the Ekole Creek. It is inferred that the dredging activities have negative effects on the water quality, which can be hazardous to the health of downstream user, and distort the ecosystem; therefore the commercial dredging activities should be checked in Ekole creek.
IMPACT OF CHANGING ABSORBER SHAPE ON AN AIR FLOW BEHAVIOR IN A THERMO-SOLAR CONVERTER
Authors: Benzenine Hamidou , Abboudi Said , Saim Rachid
Published: December 2021

In this paper, a two-dimensional numerical study of heat exchange by forced convection of an incompressible laminar flow in a solar air heater duct (SAH), which is equipped with a shoulder attached to the absorber, was performed. The impact of three locations of this shoulder and their three heights on friction losses, as well as the drag coefficient, the variations of velocity, and temperature at the exit section of the SAH, were analyzed for a volume flow rate in the range [20-80 m3/h.]. The results obtained numerically prove that the insertion of a shoulder on the absorber improves the heat transfer and the dynamics of the flow very significantly. An average temperature difference (inlet-outlet) of the collector of 23.51 °C at 29.94 °C and 50.64 °C at 67.53 °C is acquired respectively for the high and the low flow rates. This paper also showed that the height of the shoulder used can ensure an acceleration of the flow with an axial variation of the order of 1.25 up to 2.5 times (> twice) compared with the simple case.
Hareket Yakalama ve Sanal Gerçeklik Teknolojileri Kullanarak Oyun Tabanlı Rehabilitasyon
Authors: ALAKUS Ferdi , ISIK Ali Hakan , ESKİCİOĞLU Ömer Can
Published: December 2021

İnsanların kas ve sinir sisteminin tahribatı ile ortaya çıkan hastalıklar hayat kalitesi üzerinde ciddi etkiler göstermektedir. Bu hastalıklardan en önemlilerden biri hemiplejidir. Hemipleji, diğer bir adıyla kısmi felç, vücudun sol ve sağ bölgelerini etkileyen sinir sistemi hastalığıdır. Söz konusu hastalıkta, bireylerin beyinlerinde meydana gelen hasarlardan dolayı hareket edememe veya hareket etmekte güçlük yaşanılması gibi sorunlar oluşmaktadır. Bu hastalıkta tedavi ve rehabilitasyon aşaması son derece önemlidir. Hastalığı erken teşhis ederek rehabilitasyon süreci hemen başlatılmalıdır. Diğer vücut fonksiyonlarına zarar verilmeden iyileşme sağlanması tedavinin temel amacıdır. Çalışmamızda, rehabilitasyon süreci aşamasındaki hastaların hareketlerini algılayarak, oyun tabanlı bir sanal gerçeklik uygulaması geliştirilmiştir. Hastanın parmaklarına 10 adet esneklik sensörü ve eklemlerine 13 adet MPU9250 eğim sensörü olmak üzere toplamda 23 adet sensör yerleştirilmiştir. Sensörlerden alınan veriler öncelikle kalibre edilmiştir. Kalibre edilmiş sensörlerden, sanal gerçeklik gözlüğüne gelen gerçek zamanlı veriler ile hemipleji hastalarının hareketleri algılanmıştır. Hemipleji hastalarına uzman fizyoterapistler tarafından verilen hareketlere uygun oyun modu tasarlanmıştır. Sanal gerçeklik gözlüğü takılı olan hasta, oyun moduna göre oyun oynayabilmektedir. Gözlükte gösterilen ve uygulanması istenilen oyun, fizyoterapistler tarafından belirlenmiş hareketlere bağlı bir oyundur. Çalışmanın hemipleji hastalarının iyileşme sürecine önemli katkı sağlayacağı düşünülmektedir.
Child Writing and the Traumatised Body
Authors: Lieffers Caroline
Published: December 2021

Texts by young conflict survivors, including the children of Hiroshima and Nagasaki, are worthy of historical and literary consideration on many fronts. How did young people experience, understand, and cope with damage to their bodies? What stigma did they face, and how did they make sense of their changed futures? How did they translate their experiences into prose, and how did they negotiate the meanings that such prose held within their societies? This essay suggests that juvenilia offers a deep well for other fields—trauma studies, the history of childhood, and even disability studies—to consider, and juvenilia studies might also incorporate new theoretical apparatuses that can help elucidate the personal, social, and political implications of young writers’ experiences of trauma and injury. Attention to children’s writing about their injuries may approach the asymptote of their trauma and offer insights for scholars working from numerous disciplinary points of origin.
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Child Journalists, the Civil War, and the Intersectional Work of Reporting Grief
Authors: Danger Sara
Published: December 2021

In 1864, editors of two nationally-circulating periodicals, Nellie Williams (aged 14) and her sisters, Allie and Mary (aged 12 and  17), reported that their only brother and Union Soldier, Leroy K. Williams, was missing in action.  Filtering personal trauma through the performative discourses of nineteenth-century journalism, these young writers publicised their anguish over their brother’s capture. The culturally-situated intersectional identities reflected in and contested by their reporting—as white Northerners, working-class youth, loyal sisters, and enterprising journalists—expose a kaleidoscope of fissures and collisions between private and public, silence and enunciation, gender and class, trauma and resilience. The resulting tensions illustrate the ways by which genres shaped, and were shaped by, children’s articulations of suffering for a national audience during wartime.
Trauma in Phillis Wheatley’s Juvenilia
Authors: Hodgson Lucia Hodgson
Published: December 2021

Reading Wheatley’s writings as juvenilia and considering her poetry and letters in relation to one another can productively complicate the view that her poetry is devoid of traumatic affect. This approach illuminates her agency in grappling with how to represent her traumatic childhood experiences. To hear trauma in Wheatley’s poetry requires recognition of her agency in representing her traumatic childhood experiences and their effects on her memory, attachment, and affect. This essay argues that the poems Wheatley published while under age twenty-one provide insight into the challenge of representing the traumatic separation from her mother when her physical and psychic survival depended on her affective relationship with her mistress Susanna Wheatley. What we can hear in Wheatley’s poetry about her childhood in Africa and her upbringing in the Wheatley household must be teased out of the performance of obedience and gratitude expected of her as an enslaved child.
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Introduction to Editor's Column
Authors: Conrad Rachel
Published: December 2021

This essay introduces the Editor’s Column of this issue of the Journal of Juvenilia Studies, a special feature consisting of five essays exploring complexities of trauma, intersectionality, and juvenilia through focusing on a youth-authored text. The five essays emerge from different disciplinary perspectives, attend to a range of historical and geographical locations, and focus on young writers who are from marginalised backgrounds and/or are not typically at the center of scholarly attention. This introductory essay raises the point that further conceptual work is needed regarding trauma and forms of oppression; questions of age, power, and intersectionality; and the nature of our access to young people’s perspectives in relation to intersectionality and trauma. The essay concludes by suggesting that engaging with questions of trauma, intersectionality, and juvenilia requires specifying, broadening, and deepening our frames.
Perilaku Pemilihan Makanan dan Pengenalan Anggota Koloni pada Semut Rangrang Oecophylla smaragdina
Authors: Hasan M. Ubaidilah Hasan , Fitradiansyah La Ode Fitradiansyah , Susanti Fera Susanti , Raffiudin Rika
Published: December 2021

Weaver ants Oecophylla smaragdina are social insects that recognize nestmates using pheromone. This study analyzes the feeding behavior and nestmate recognition of weaver ants in the urban area of three different islands (Sumatra: Baturaja; Java: Banyuwangi; Papua: Sorong). The free ants were placed in the arena composed of chicken meat, sugar, bananas as the baits. Ten trapped ants were also located in the arena to explore the nestmate recognition between the free and the trapped ants. Five types of behaviors, i.e., approach, stalking, communication, competition, and agonistic, were recorded in 6 days. Food preferences were indicated by the number of conduct towards the feeding sites, and nestmate recognition was indicated by approaching the trapped nestmate. The results showed that the percentage of the approach behavior of free ants was the highest in the three islands but had no significant difference between Sumatra and Java and between Java and Sorong (p-value >0.05). However, the study showed significant differences for the other four behaviors observed. As predicted, the percentage of chicken meat foraged by the ants was the highest due to the carnivorous behavior. The free ants showed the nestmate recognition to the trapped ants in all behavior, except competition.
TRANSCULTURAÇÃO NA ARQUITETURA DO CHÁ NO VALE DO RIBEIRA: Arquiteturas vernáculas japonesa e cabocla
Authors: Danilewice Leonardo Vicente , Feitosa Lucas de Souza Ramalhaes , Montenegro Filho Roberto Alves de Lima
Published: December 2021

Aarquitetura produzida por imigrantes japoneses no Vale do Ribeira constitui importante patrimônio histórico/culturalbrasileiro, paulista, do Vale do Ribeira (tratando-se de episódio
Reachability results in labelled \(t\)-ary trees
Authors: Okoth Isaac Owino , Nyariaro Albert Oloo ,   Department of Pure and Applied Mathematics, Maseno University, Kenya
Published: December 2021

In this paper, we prove some new formulas in the enumeration of labelled \(t\)-ary trees by path lengths. We treat trees having their edges oriented from a vertex of lower label towards a vertex of higher label. Among other results, we obtain counting formulas for the number of \(t\)-ary trees on \(n\) vertices in which there are paths of length \(\ell\) starting at a root with label \(i\) and ending at a vertex, sink, leaf sink, first child, non-first child and non-leaf. For each statistic, the average number of these reachable vertices is obtained for any random \(t\)-ary tree.
Tail distribution estimates of the mixed-fractional CEV model
Authors:   Department of Mathematics, Hanoi University of Mining and Geology, 18 Pho Vien, Bac Tu Liem, Hanoi, 084 Vietnam, Hang Nguyen Thu , Thuy Pham Thi Phuong ,   The faculty of Basic Sciences, Vietnam Air Defence and Air Force Academy, Son Tay, Ha Noi, 084 Vietnam
Published: December 2021

The aim of this paper is to study the tail distribution of the CEV model driven by Brownian motion and fractional Brownian motion. Based on the techniques of Malliavin calculus and a result established recently in [1], we obtain an explicit estimate for tail distributions.
MANAGING ECONOMIC SECURITY OF AN INTERNATIONAL VENTURE: A PSYCHOLOGICAL PERSPECTIVE
Authors: Voroniuk Yevheniia V. , Satusheva Karina V.
Published: December 2021

This article seeks to provide argument that effective performance in modern realia of business and management is impossible without understanding the socio-psychological processes that accompany entrepreneurial endeavours. Further development of market competition in the national economy, its inclusion in the system of global economic relationships, aggravation of internal barriers to successful implementation of economic reforms significantly raise the issue of exploring a psychological aspect of economic security of businesses, and in international ventures, in particular. An emphasis is put that the roots of genesis and evolution of economic psychology refer to radical changes, especially changes occurred in the economic paradigm and attitudes towards ownership for the means of production in the first place, as well as the emergence of new economic actors. Apart from that, pressing globalization trends, changes in political and economic patterns, as well as rapid technological advances in society have greatly affected socio-cultural values of the population. However, even the very speed and extent of global change faced by modern society depends on psychological characteristics inherent in different social groups. Different psychological patterns and perspectives that drive the development of business environment world-wide have created a new background for shaping and launching new economic security strategies for international business entities and ventures. The findings have verified that business economic security directly relates to management's understanding of the needs and the specifics of business structure and their alignment with the personal goals of the leader. Moreover, business operation of economic entities, both in the external and internal environment, encourages them to search for the new pathways and raise awareness of the need for effective interaction between the internal corporate culture and its organizational structure, ensuring and managing economic security and values of international markets. To attain the above objectives, a thorough research on the international business environment is of critical significance. It is argued that deep insights into psychological factors driving drastic change in the politicians’ perceptions of the need to make a shift from a planned socialist paradigm to a market economy, exploring the psychology of transformation of the theoretical concepts from Marxist political economy to Western market theories will facilitate better understanding of the nature of economic security of international ventures.
Advanced Therapy Medicines Based on Oncolytic Viruses (Part II: Development and Authorisation of IMLYGIC®)
Authors: Melnikova E. V. , Rachinskaya O. A. , Merkulov V. A.
Published: December 2021

The only oncolytic virus-based product authorised in the US and EU—IMLYGIC®, a genetically modified herpes simplex virus type 1 (by BioVex Inc., a subsidiary of Amgen, Inc.)—was developed and approved for clinical use as monotherapy for recurrent unresectable melanoma. The aim of the study was to analyse materials on IMLYGIC® development and authorisation in order to be able to use the data on specific aspects of preclinical and clinical trials of oncolytic virus-based products in the development of regulatory framework for Russia and the EAEU. The publicly available preclinical and clinical trial results demonstrate a decrease in the size of both tumours being injected and remote tumours/skin lesions, which supports the local and systemic effects of IMLYGIC® due to the lysis effect of the virus on the tumour cells. The clinical trials of IMLYGIC® were the first to use the durable response rate, and not the overall survival, as the primary endpoint of the efficacy of the anticancer drug. Benefits of IMLYGIC® therapy were observed across all the secondary endpoints, except overall survival. Significant efficacy of the drug therapy was demonstrated only in patients without visceral lesions, which resulted in limitations of indications for use. There have been no serious or severe adverse effects associated with IMLYGIC®. If symptoms of viral infection develop, they can be neutralized thanks to the product’s sensitivity to acyclovir. At present, advanced therapy medicinal products derived from an oncolytic virus may be authorised in Russia for clinical use as monotherapy or combination therapy, according to the EAEU regulations.
Preparation of a Nonclinical Overview Based on Scientific Literature
Authors: Engalycheva G. N. , Syubaev R. D.
Published: December 2021

Current requirements for the registration dossier include submission of a preclinical (nonclinical) overview, including scientific literature data on preclinical studies and actual preclinical data on the medicinal product. For some groups of medicines, scientific literature data may be used instead of actual preclinical data, which may be redundant. One of the important functions of the scientific literature review is the analysis of updated preclinical information on the medicinal product, which reflects the product’s characteristics, supports conclusions on its efficacy or safety, and may affect the results of the benefit/risk assessment. The aim of the study was to determine the optimal format for presenting scientific literature data in a nonclinical overview that would reflect the methodological aspects of preclinical pharmacology and toxicology studies of medicines. The authors analysed the regulations of the Russian Federation and the Eurasian Economic Union containing requirements for the scientific literature review submitted instead of actual preclinical data as part of the registration dossier for a medicinal product. The authors also considered potential difficulties in preparing a nonclinical overview based on scientific literature. In order to systematise scientific literature data, it is recommended to provide pharmacodynamic, pharmacokinetic, and toxicological data using a format consistent with the common technical document. The proposed recommendations help to harmonise the process of preparation and design of a nonclinical overview which should contain data and facts enabling a reasoned assessment of the benefit/risk ratio. The standardised format of literature data presentation will help the developer prepare an adequate nonclinical overview and will speed up assessment of clinical trial or marketing authorisation applications.
Recommendations for the Contents of the “Peptide Mapping” Part of a Product Specification File
Authors: Vaganova O. A.
Published: December 2021

‘Identification. Peptide mapping’ is a necessary part of manufacturers’ product specification files for therapeutic proteins (active ingredients and final products of monoclonal antibodies, filgrastims, erythropoietins). The expert of the Federal State Budgetary Institution “Scientific Centre for Expert Evaluation of Medicinal Products” of the Ministry of Health of the Russian Federation provides recommendations for a step-by-step presentation of the test procedure, which will allow applicants to align product specification files for Russian- and foreign-produced medicinal products, help experts to minimise or eliminate the need to request additional information from applicants, and will contribute to timely batch release of medicinal products.
Дизайн, синтез и противоязвенная активность новых производных 1-тиа-4,8-диазаспиро[4.5]декан-3-она
Authors: Иванкин Дмитрий Игоревич , Борисова М. С. , Соколов Д. Н. , Лузина О. А. , Толстикова Т. Г. , Салахутдинов Н. Ф.
Published: December 2021

Синтезирована серия соединений на основе 1-тиа-4,8-диазаспиро[4.5]декан-3-она. На модели in vivo изучена их активность в качестве новых противоязвенных агентов. Обнаружено, что 8-бензил-4-(3-(диметиламино)пропил)-1-тиа-4,8-диазаспиро[4.5]декан-3-он, 8-бензил-4-(2-(диметиламино)этил)-1-тиа-4,8-диазаспиро[4.5]декан-3-он, 4,8-дибензил-1-тиа-4,8-диазаспиро[4.5]декан-3-он и 8-бензил-4-(3-(дибутиламино)пропил)-1-тиа-4,8-диазаспиро[4.5]декан-3-он проявляют противоязвенную активность, сравнимую с активностью препарата сравнения Омепразол®.
Цитотоксическая активность гетероциклических соединений, содержащих гем-дихлорциклопропановый и/или 1,3-диоксациклоалкановый фрагменты, в отношении клеток линии SH-SY5Y
Authors: Кузьмина Ульяна Шафкатовна , Раскильдина Гульнара Зинуровна , Ишметова Диана Валиевна , Сахабутдинова Гульнур Назифулловна , Джумаев Шахобиддин Шамсидинович , Борисова Юлианна Геннадьевна , Вахитова Юлия Венеровна , Злотский Семен Соломонович
Published: December 2021

Изучены цитотоксические свойства in vitro простых и сложных эфиров, а также кетонов, содержащих гем-дихлорциклопропановый и/или 1,3-диоксациклоалкановый фрагменты, с использованием клеточной линии нормального (HEK293, клетки эмбриональной почки человека) и опухолевого (SH-SY5Y, клетки нейробластомы человека) происхождения. Выявлены соединения, оказывающие избирательный токсический эффект в отношении клеток SH-SY5Y: 4,4-[1,2-дифениленбис(метиленоксиметилен)]бис(2,2-диметил-1,3-диоксолан) (IC50 = 33,21 ± 1,34 мкМ), [3-(бутоксиметил)-2,2-дихлорциклопропил]бензен (IC50 = 88,60 ± 6,93 мкМ), 1,2-бис{[(2,2-дихлорциклопропил)метокси]метил}бензен 23 (IC50 = 90,90 ± 5,78 мкМ). Высокие индексы селективности (SI) установлены для 4-({[(2-хлорметил)бензил]окси}метил)-2,2-диметил-1,3-диоксолана (SI = 8,03) и 4,4-[1,2- дифениленбис(метиленоксиметилен)]бис(2,2-диметил-1,3-диоксолана) (SI = 3,01). Результаты исследования позволяют определить направления синтеза новых цитотоксически активных гетероциклических веществ с гем-дихлорциклопропановым и/или 1,3-диоксациклоалкановым фрагментами, специфично действующих на клетки SH-SY5Y.
Синтетические низкомолекулярные соединения как потенциальные ингибиторы адгезии Staphylococcus aureus в эксперименте
Authors: Божкова Светлана Анатольевна , Гордина Екатерина Михайловна , Лабутин Дмитрий Владимирович , Соколов Михаил Николаевич , Кудрявцев Константин Викторович
Published: December 2021

Уменьшение адгезии золотистого стафилококка предоставляет дополнительные возможности для профилактики и терапии инфекционных заболеваний, вызываемых, в том числе, резистентными штаммами. В настоящей работе с использованием оптической микроскопии исследовано взаимодействие штамма S. aureus АТСС 29213 и эпителиальных эукариотических клеток и установлены низкомолекулярные органические соединения класса 5-арилпирролидин-2-карбоксилатов, индуцирующие снижение адгезии бактериальных клеток к клеткам Vero. Рацемический метил (2S*,4S*,5R*)-4-(гидроксиметил)-1-метил-5-(2-фтор-5-метоксифенил)пирролидин-2-карбоксилат вызывает статистически значимое ингибирование адгезии типового штамма S. aureus и характеризуется отсутствием цитотоксичности в отношении как эукариотических клеток линии Vero, так и изученного штамма S. aureus.
Оптимизация технологии прессования таблеток ГК-2 – гексаметиленамида бис-(N-моносукцинил-L-глутамил-L-лизина), диспергируемых в полости рта, с применением математических моделей хеккеля и кавакита
Authors: Тишков Сергей Валерьевич , Блынская Евгения Викторовна , Алексеев Константин Викторович , Буева Виктория Владимировна
Published: December 2021

Оптимизация процесса прессования в настоящее время является одной из актуальных задач фармацевтической промышленности, поскольку данная технологическая стадия во многом определяет поведение готовой лекарственной формы в организме, при транспортировке и хранении. В данной статье проведено изучение отобранного модельного состава таблеток ГК-2 — гексаметиленамида бис-(N-моносукцинил-L-глутамил-L-лизина), диспергируемых в полости рта, для прямого прессования методами математического моделирования, такими как уравнения Хеккеля и Кавакита. Рассмотрены процессы, происходящие при различном усилии прессования, показано преобладание пластической деформации, описана доля фрагментации, определён предел текучести состава. С помощью уравнения Кавакита определен вклад перераспределения частиц состава в начальный период прессования при низких давлениях и выявлено значение давления прессования, при котором происходит уменьшение объёма таблеточной смеси на 50 %. Кроме того, в результате анализа значений прочности таблеток на раздавливание, получено уравнение квадратичной регрессии, позволяющее предсказывать прочность таблеток при различных усилиях прессования. Исходя из полученных данных оптимального интервала давлений прессования и значений распадаемости, определено наиболее приемлемое значение усилия прессования для изучаемого состава.
Разработка и валидация аналитической методики количественного определения ацетилсалициловой кислоты и ее метаболита салициловой кислоты в плазме крови человека методом ВЭЖХ-МС/МС
Authors: Церковная Ксения Михайловна , Флисюк Елена Владимировна , Шабров Виталий Николаевич
Published: December 2021

В ходе данного исследования разработана и валидирована аналитическая методика количественного определения ацетилсалициловой кислоты (ASA) как антиагрегантного средства и ее метаболита салициловой кислоты (SA) в плазме крови человека методом ВЭЖХ-МС/МС. Установлен оптимальный диапазон концентраций для ASA (0,020 – 1,200 мкг/мл) и SA (0,200 – 12,000 мкг/мл), подобраны оптимальные условия пробоподготовки методом жидкость-жидкостной экстракции этилацетатом с последу-ющим удалением растворителя в токе азота и перерастворением сухого остатка (с целью концентрирования пробы для повышения чувствительности методики), хроматографирования и масс-спектрометрического детектирования. Разработанная методика может быть использована в дальнейшем при проведении фармакокинетических исследований и исследований биоэквивалентности.
De Moivre-Type Identities for the Padovan Numbers
Authors: AKBIYIK Mücahit , YAMAÇ AKBIYIK Seda , ALO Jeta
Published: December 2021

At this work, we give a method for constructing the Perrin and Padovan sequences and obtain the De Moivre-type identity for Padovan numbers. Also, we define a Padovan sequence with new initial conditions and find some identities between all of these auxiliary sequences. Furthermore, we give quadratic approximations for these sequences.
Analisis Sektor Unggulan Dalam Pembangunan Daerah di Kabupaten Sidoarjo
Authors: Muljanto Muhammad Agus
Published: December 2021

Pertumbuhan ekonomi Kabupaten Sidoarjo direpresentasikan dengan adanya peningkatan PDRB dalam kurun waktu 2016-2020 (kecuali tahun 2020 mengalami penurunan). Terlebih data PDRB dimaksudkan untuk mengevaluasi kinerja pembangunan ekonomi Kab. Sidoarjo melalui berbagai sektor pembangunan. Untuk itu diperlukan analisis terhadap sektor yang menjadi basis pembangunan ekonomi dan scktor unggulan yang berkontribusi besar pada pertumbuhan ekonomi wilayah serta sektor unggulan tersebut dapat menjadi prioritas dalam perencanaan pembangunan ekonomi wilayah. Penelitian ini bertujuan untuk mengetahui sektor yang menjadi basis dan sektor unggulan (metode LQ dan DLQ)  serta sektor yang menjadi prioritas (tipologi Klassen) yang berkontribusi pada pertumbuhan ekonomi Kabupaten Sidoarjo. Metode penelitian yang digunakan adalah deskriptif kuantitatif yang menyajikan gambaran suatu fenomena tentang apa yang dialami objek penelitian dengan menggunakan angka-angka. Hasil penelitian menunjukkan 14 (empat belas) sektor dapat menjadi basis pembangunan ekonomi di Kabupaten Sidoarjo dan 1 (satu) sektor diantaranya menjadi sektor unggulan sebagai prioritas dalam mengakselerasi  pertumbuhan ekonomi Kabupaten Sidoarjo, yaitu sektor Industri Pengolahan. Untuk itu strategi perencanaan pembangunan yang berkontribusi besar pada pertumbuhan ekonomi wilayah dapat dilakukan dengan memberikan prioritas tinggi kepada sektor Industri Pengolahan.
Kata Kunci: Basis pembangunan ekonomi, Sektor unggulan, Metode LQ dan DLQ, tipologi Klassen, Pertumbuhan ekonomi daerah
Relationship of tooth loss to mild cognitive impairment among middle-aged Mongolians: Mon-Timeline study
Authors: Ganbaatar Urangoo , Gantulga Oyuntuya , Byambajav Puntsagdulam , Och Maralgua , Ganburged Ganjargal , Jadamba Tsolmon , Dagvajantsan Byambasuren , Byambasukh Oyuntugs
Published: December 2021

Cognitive impairment is common in elderly people, so it is considered an ageing disorder. However, cognitive decline, including dementia, can also occur in middle-aged people. Cognitive impairment is associated with multiple risk factors. We hypothesised that tooth loss might also be a potential risk factor among Mongolians, as oral health problems are one of the significant health issues in Mongolia, especially in middle-aged people. In this cross-sectional study, we used the baseline data from the Mon-Timeline cohort study, including people older than 40 years of age (n=279). The amount of tooth loss was assessed by a trained researcher. Mild cognitive impairment (MCI) was defined as those participants scoring a total of £ 24 points based on the Mini-Mental State Examination (MMSE). Unadjusted analysis showed that having more tooth loss (>10) increased the risk of MCI by an odds ratio of 3.03 (1.49-6.17), as compared with having less tooth loss (£10). Even after adjusting for covariates, the association remained significant, suggesting that tooth loss is associated with MCI risk, independent of age, education, and other socioeconomic factors. There was no significant interaction effect of age in the association between tooth loss and MMSE scores. In conclusion, tooth loss may play a role in developing cognitive decline, especially in the early onset of dementia. Further studies are needed to investigate whether early tooth loss at younger ages is associated with dementia, especially among middle-aged people.
KOMUNIKASI MELALUI TEKNOLOGI & MEDIA SOSIAL
Authors: Yazid Sitti Amani
Published: December 2021

Disusun dalam rangka memenuhi salah satu tugas kelompok pada mata kuliah Sistem Komunikasi Bisnis Semester 5 tahun 2021. Perkembangan teknologi digital didukung oleh kekuatan Internet telah membawa banyak sekali perubahan yang luar biasa, termasuk bidang komunikasi. Perkembangan di bidang komunikasi berteknologi digital telah melahirkan berbagai jenis media komunikasi, mulai dari komunikasi luar angkasa dan kemiliteran yang sangat rumit, sampai pada telepon genggam yang digunakan dalam kehidupan sehari-hari, baik untuk berbisnis atau sekedar menanyakan kabar pada seorang teman dalam kehidupan sosial. Bagaimana peran teknologi komunikasi digital berupa kelahiran telepon pintar dalam kehidupan manusia inilah yang akan dibahas dalam tulisan ini
Teori Atau Konsep Dasar Algoritma Pemrograman Pembelajaran Dasar Dan Struktur Algoritma
Authors: batubara Muhammad ilham maulana
Published: December 2021

Algoritma adalah klarifikasi atau penggambaran tentang cara-cara mengurus masalah yang diorganisir secara efisien. Algoritma juga merupakan strategi sukses yang dapat dikomunikasikan sebagai rangkaian terbatas. Algoritma akan menjadi landasan dalam pembuatan program yang layak. Jadi perpaduan algoritma dan pemrograman akan membuat program berbasis aplikasi yang layak yang memenuhi kebutuhan Anda. Sebuah program adalah bermacam-macam proklamasi PC. Untuk sementara, tahapan teknik dan metodis dalam program adalah algoritma. Dengan memanfaatkan suatu algoritma yang merupakan suatu strategi atau keputusan yang dapat mengelola program, maka akan ada suatu standar yang menjadi batasan dan batasan suatu program aplikasi. Sehingga klien dapat mengetahui cara kerja program yang telah diakumulasikan oleh pengembang atau pembuat program.
Sistem hukum Adat Dan Kepercayaan Masyarakat Bugis
Authors: Firdaus Ashari
Published: December 2021

Bugis adalah suku yang tergolong ke dalam suku-suku Deutero Melayu. Masuk ke Nusantara setelah gelombang migrasi pertama dari daratan Asia tepatnya Yunan. Kata "Bugis" berasal dari kata To Ugi, yang berarti orang Bugis. Penamaan "ugi" merujuk pada raja pertama kerajaan Cina yang terdapat di Pammana, Kabupaten Wajo saat ini, yaitu La Sattumpugi. Ketika rakyat La Sattumpugi menamakan dirinya, maka mereka merujuk pada raja mereka. Mereka menjuluki dirinya sebagai To Ugi atau orang-orang atau pengikut dari La Sattumpugi.Suku Bugis merupakan penduduk asli Sulawesi Selatan. Di samping suku asli, orang-orang Melayu dan Minangkabau yang merantau dari Sumatera ke Sulawesi sejak abad ke-15 sebagai tenaga administrasi dan pedagang di kerajaan Gowa, juga dikategorikan sebagai orang Bugis. Berdasarkan sensus penduduk tahun 2000, populasi orang Bugis sebanyak 6 juta jiwa. Kini suku Bugis menyebar pula di provinsi Sulawesi Tenggara,Sulawesi Tengah, Papua, Kalimantan Timur, Kalimantan Selatan, bahkan hingga manca negara. Bugis merupakan salah satu suku yang taat dalam mengamalkan ajaran Islam.
MENYUSUN LAPORAN KEUANGAN
Authors: Afni Nurul
Published: December 2021

Krisis ekonomi memberikan dampak sangat besar terhadap perekonomian di Indonesia. Perusahaan-perusahaan besar yang ditopang modal asing terpaksa gulung tikar. Sektor riil yang diwakili usaha kecil menengah menjadi penyelamat dan sebagai dinamisator perekonomian. Layanan Pemeriksaan Histopatologi (PA) & Sitologi dr. Soebarkah Basoeki, SpPA Malang yang merupakan salah satu usaha kecil menengah, yang memerlukan standar khusus sebagai pedoman dalam pembuatan laporan keuangan. Penelitian ini membahas mengenai analisis kemungkinan pemakaian standar keuangan yang baku diperuntukkan untuk usaha kecil menengah, khususnya dalam hal penyusunan dan penyajian laporan keuangan berdasarkan Standar Akuntansi Keuangan Entitas Tanpa Akuntabilitas Publik (SAK ETAP). Tujuan dari penelitian ini adalah untuk mengetahui apakah laporan keuangan yang disajikan layanan pemeriksaan PA KG sudah sesuai dengan standar yang berlaku ataukah belum. Metode yang digunakan adalah deskriptif kuantitatif yang memberikan gambaran mengenai penyusunan dan penyajian laporan keuangan berdasarkan SAK ETAP. Jenis penelitian yang digunakan yaitu studi kasus. Teknik pengumpulan data dengan wawancara, dokumentasi, dan juga studi literatur. Hasil analisis menunjukkan bahwa laporan keuangan yang disajikan oleh Layanan pemeriksaan ini masih sangat sederhana dan belum sesuai dengan standar yang berlaku. Proses pencatatan yang digunakan masih menggunakan cash basis. Laporan yang disajikan hanya berupa laporan pemasukan dan pengeluaran kas saja. Dengan adanya penelitian ini diharapkan dapat membantu usaha tersebut dalam hal penyajian laporan keuangan yang sesuai dengan standar yang berlaku agar dapat digunakan sebagai sarana pengambilan keputusan secara lebih tepat. Penelitian ini hanya menganalisis 3 laporan keuangan, yaitu laporan laba rugi, laporan perubahan ekuitas, dan neraca saja. Diharapkan untuk penelitian selanjutnya, khususnya untuk penelitian di Layanan PA KG, dapat melanjutkan untuk menganalisis laporan keuangan lainnya, serta dapat lebih spesifik lagi dalam menganalisis
MAKALAH MANAJEMEN STRATEGI PERBANKAN SYARIAH
Authors: Mutmainnah  , Takwa Andi Nur Muwafiqah , Faradina Andi Fadia
Published: December 2021

Artikel ini membahas tentang analisis lingkungan dalam perbankan syariah
ARTIKEL ALGORITMA PEMROGRAMAN VINNIA RISA AMALYA
Authors: AMALYA VINNIA RISA
Published: December 2021

Pelajaran ini akan menunjukkan kepada Anda cara menggunakan Google Classroom untuk menerapkan pembelajaran campuran dan meningkatkan kemandirian siswa. Metode survei dengan deskripsi kuantitatif. Partisipan dalam penelitian ini berjumlah 126 mahasiswa semester ganjil tahun 2020. Peralatan penelitian menggunakan angket skala likert. Dengan menerapkan blended learning berdasarkan hasil penelitian ini, siswa dapat belajar lebih mandiri. Hasil untuk masing-masing indikator meliputi independensi 81,23% dan keyakinan 74,98%. 80, 41% perilaku disiplin, 79,52% tanggung jawab. Perilaku terjadi secara spontan pada 80% dan 76%.Latihan 79,72% pengendalian diri. Berdasarkan hasil tersebut, blended learning berpotensi menjadi alternatif pendidikan yang cocok untuk meningkatkan kemandirian belajar siswa. Kata kunci: blended learning, Google Classroom, pembelajaran mandiri.
新型コロナウイルス感染症のヘルスリテラシーと心身の健康及び生活への影響との関連
Authors: Hirai Kei , Yamamura Asayo , Kato Mai , Yagihashi Mao , Miura Asako
Published: December 2021

In our previous study Survey 1, we found infection prevention behaviors were characterized by health literacy and found to be divided into six segments: "majority/social defense”, “self-judgment/self-protection”, "threat denying”, "hoax affinity/optimism," "vigilance/self-protection”, and "hyper-vigilance/social defense”.The purpose of this study is to examine the real-life influences and behaviors of different types of health literacy. The 3,800 respondents to Survey 2 were asked to answer again, and the 3,000 who responded were targeting in the study.In the result, we found that "majority/social defense" and "hyper-vigilance/social defense" were lowered in their visits to the hospital for the purpose of prevention and visitation. In addition, the intention to vaccinate was lower for "hoax affinity/optimism" and "Threat denial”. Furthermore, "Threat denial" was the highest that respondents thought vaccines were unnecessary.This study revealed there were two potential high-risk factors in the life under infectious disaster. In the first, it is suggested that early detection of serious diseases may be delayed, resulting in a higher health risk than having an infectious disease. In the second, it is suggested that "hoax affinity/optimism" and "threat-denying" segments may be less likely to be vaccinated, and it is considered the segments needed the highly supports when infection prevention measures would be promoted.
Constructing a graphical model of the relationship between physical activity and cognitive function based on a systematic review of prospective evidence
Authors: Campbell Thomas , Ferguson Karl , Whyte Jessica , Cullen Breda
Published: December 2021

Elucidating the factors that contribute to healthy ageing is an important research goal. Physical activity (PA) has been associated with benefits for cognitive function (CF). However, most of this evidence comes from longitudinal cohort studies which, in the absence of experimental design, have limited scope to make causal inferences regarding observed relationships. This review aimed to utilise recent methodological developments allowing researchers to formulate and answer stronger causal questions using observational data, by following a best-practice method for synthesising evidence to produce a graphical causal model known as a directed acyclic graph (DAG). Following a search of 3 databases (EMBASE, MEDLINE and PsycINFO), 21 observational studies on the PA-CF relationship were reviewed and their methodological quality, characteristics, and key findings were summarised. The outcomes of interest were the covariates and modelling practices employed in each study. The reported covariates were synthesised against a set of criteria to determine their role in the DAG as confounders or mediators of the PA-CF relationship. Every included study had some areas of methodological weakness. The resulting DAG included a wide range of biopsychosocial covariates spanning the entire life-course and indicated potential intermediate pathways between PA and CF via structural brain health. Strengths, limitations and implications of this review for modelling decisions are discussed, prior to the model being taken forward to inform an empirical analysis using data from the UK Biobank cohort, separate from this review.
Tailor Made, Skylarking, and Making in the Humanities
Authors: Tracy Dale
Published: December 2021

Reacting to the symbolic features and historical artefacts that invite institutional self-reflection at the Royal Military College (RMC), I created a performance project leading to two storytelling events. Everyday campus life at RMC already offers opportunities for cultivating a meta-perspective – a higher-order awareness – of the institution, and the storytelling events called attention to such opportunities. I argue that, likewise, art-based projects in the humanities call attention to the creativity – the making – involved in the humanities more broadly. The first storytelling event, Tailor Made (2017), comprised stories focused on the uniform as a model and the body wearing it as an actual bearing out that model. Social and cultural life is made of the difference between models and actuals, and each story engaged the ways in which rules, systems, and practices meet with individuals in hurtful, inconvenient, funny, or messy ways. The second event, Skylarking (2018), included stories of the institutionally condoned pranks called “skylarks” and coincidentally occurred against the backdrop of a campus-wide punishment that elicited a skylark response. This event and its context showed that marking disruption with more disruption (marking failure with punishment and marking punishment with prank) is a recursion that invites higher-order thinking about existing orders.
Critical-Creative Literacy and Creative Writing Pedagogy
Authors: Clifton Glenn
Published: December 2021

This article builds on psychological research that claims critical thinking is a key component of the creative process to argue that critical-creative literacy is a cognitive goal of creative writing education. The article also explores the types of assignments and prompts that might contribute to this goal and simultaneously build bridges between creative writing education and other humanities disciplines.
Agrarian North Caucasus: the main directions of spatial development in the strategy of macroeconomic management
Authors:   Federal Scientific Center of Agrarian Economy and Social Development of Rural Areas – All-Russian Research Institute of Agricultural Economics (VNIIESH), Moscow, Russia, Zhukov Nikolay I. , Voronin Evgeniy A. ,   Federal Scientific Center of Agrarian Economy and Social Development of Rural Areas – All-Russian Research Institute of Agricultural Economics (VNIIESH), Moscow, Russia
Published: December 2021

Using the example of the North Caucasus Federal District (NCFD), the article substantiates the main theoretical and methodological directions of spatial development of agriculture in geostrategic territories. This will make it possible to develop strategic institutional and regulatory documents for influencing the process of spatial development of the North Caucasus rural economy, whose development has not yet reached even the pre-reform level due to maladaptive macroeconomic policies. There was a dramatic drop in agricultural production due to the deindustrialization of the rural economy of the North Caucasus Federal District, the introduction of an unregulated spontaneous market, private land ownership. The spatial development of the rural economy in the regions of the North Caucasus Federal District depends to a certain extent on strategic management at the federal level and includes the following problems: employment and unemployment, industrialization on a new microelectronic technological basis, training of technical personnel and the movement of part of the workforce to other regions of the country. In the land issue, the need for the formation of rental relations arises. The development of transport infrastructure will contribute to strengthening interregional exchange, horizontal and vertical integration. It is necessary to develop a non-standard, comprehensively balanced, meeting the traditional and modern conditions of work and life of the peoples of the North Caucasus, a new breakthrough macroeconomic strategy for the spatial development of these territories based on a combination of planned and market approaches.
Computer programs “CORALL”: automation of veterinary measures management
Authors:   Financial University under the Government of the Russian Federation, Moscow, Russia, Lukyanov Pavel B.
Published: December 2021

The article presents the author’s solutions for automating the diagnosis of cattle diseases, discusses approaches to managing the planning and implementation of veterinary measures implemented in the computer programs “CORALL – Diagnosis of cattle diseases” and “CORALL – Cattle farm: Herd management”, estimates the economic efficiency of the introduction and use of automated systems. The development of specialized information systems for livestock enterprises was carried out by two developers – B.V. Lukyanov and P.B. Lukyanov (the author of the article). The presence of personal computers on farms makes it possible to transfer into specialized computer programs a significant part of the routine work on planning, accounting and control of veterinary measures, and when diagnosing animal diseases, computers make it possible to actively use automated diagnostic expert systems. The introduction of modern information technologies into the practice of the zootechnician and veterinarian significantly increases the accuracy and validity of measures to protect animals and prevent diseases, and also allows to achieve more effective management of operational activities with herd animals. The use of the expert system «CORALL – Diagnosis of cattle diseases» is disclosed. This system is focused on two types of users: an Expert who fills in the knowledge base, and a User who uses the system for diagnosing diseases and obtaining certificates. When considering the software package «CORALL – Cattle farm: Herd management», the main attention is paid to the functions of planning, control and registration of veterinary measures both for an individual animal and for a planned group. Practical recommendations are given on the use of CORALL software systems when using them at livestock enterprises.
Pricing and solving export tasks on the example of dairy products
Authors:   A.A. Nikonov VIAPI, branch of Federal Scientific Center of Agrarian Economy and Social Development of Rural Areas - VNIIESkH, Moscow, Russia, Frolova Elena Yu.
Published: December 2021

The issues of food pricing are of great social importance. The global increase in prices on agri-food markets forces the public, the scientific community, state and international organizations to pay attention to the problem of economic accessibility of food products, related, on the one hand, to the level of income of the population, on the other – to the level of food prices. This has significantly increased the relevance of scientific research on food pricing at all stages of production and sale. The article discusses the problems associated with the formation of “fair” prices for dairy products on the example of one of the most prosperous “dairy” countries in the world – Switzerland, and also shows how the pricing policy of the countries reflects the solution of key tasks in the organization of dairy exports.