bluuebunny/crossref_metadata_2025 huggingface dataset:
Monophasic Synovial Sarcoma of Foot Masquerading Squamous Cell Carcinoma
Authors: Kannamma Sakthi , Sinhasan Sankappa P , Pandian Saravanan
Published: October 2022

Synovial sarcoma being a rare sarcoma typically arises near articular surface most commonly around knee joint. Hereby, a case report of a 38-year-old male with complaint of cauliflower-like proliferative growth on the plantar aspect of left foot. It rapidly progressed in size over a period of one month. Wedge biopsy was done and diagnosis of malignant mesenchymal tumour was suggested. Further clinical workup of the case was carried out and the surgeons proceeded with amputation of the foot. Gross examination of specimen showed a large, ulcerated, nodular, exophytic, cauliflower-like growth over the plantar aspect of left foot along with areas of haemorrhage and necrosis masquerading more common squamous cell carcinoma. Histopathology revealed characteristic hypocellular and hypercellular areas showing pleomorphic spindle cells in fascicles and whorls suggesting monophasic synovial sarcoma. Immunohistochemistry stains further confirmed the diagnosis. The current case report highlights the rare presentation of synovial sarcoma as a cauliflower type of growth at a rare location.
698.16961 Original Article Anaesthesia Section Analgesic Effect of Intrathecal Nalbuphine in Comparison with Fentanyl as an Adjuvant with Hyperbaric Bupivacaine (0.5%) during Spinal Anaesthesia in Lower Abdominal Surgery: A Double-blinded Randomised Clinical Study
Authors: Nath Amlan , Banu Parvin , Choudhury Debangshu Bhanja , Biswas Arunava , Naser Syed Mohammed
Published: October 2022

Introduction: Local anaesthetics are sometimes added with intrathecal adjuvants. Nalbuphine is a synthetic agonistantagonist of opioid μ receptor. Fentanyl is a highly potent lipophilic synthetic opioid with rapid onset of action and it acts like morphine. It can be used during spinal anaesthesia for the purpose of decreasing the postoperative pain. Aim: To compare the safety and efficacy of preservative free intrathecal nalbuphine and fentanyl as additives to intrathecal hyperbaric bupivacaine (0.5%) for spinal anaesthesia. Materials and Methods: A randomised double-blinded clinical study was undertaken at Calcutta National Medical College and Hospital, India during March 2020 to August 2021 in which a total of 100 patients, belonging to American Society of Anaesthesiology (ASA) I and II and undergoing elective lower abdominal surgery, were randomised into two equal group of 50 each. Group N received intrathecally 0.5 mg of nalbuphine with 3 mL (15 mg) of 0.5% hyperbaric bupivacaine, and Group F received 25 µg of Fentanyl with 3 mL (15 mg) of 0.5% hyperbaric. Visual Analogue Scale (VAS) score, Systolic Blood Pressure (SBP), Diastolic Blood Pressure (DBP), Mean Arterial Pressure (MAP) and Heart Rate (HR) were recorded at varied intervals during intraoperative and postoperative period. Results: Significantly lower (p<0.001) mean VAS scores was observed beyond six hour of postoperative period in the group F. No significant changes (p>0.05) in SBP, DBP, MAP and HR were there between the groups. Few adverse effects like (hypotension, bradycardia, nausea, vomiting) were observed more in the fentanyl group which was statistically insignificant (p>0.05). Conclusion: Intrathecal fentanyl as compared to nalbuphine produces a significant postoperative analgesia when administered as an adjuvant with hyperbaric bupivacaine in cases of lower abdominal surgery.
ВООБРАЖАЕМОЕ ПУТЕШЕСТВИЕ: ФРАНЦУЗСКИЙ МОНАРХ И ЕГО УЧАСТИЕ В ИТАЛЬЯНСКИХ ВОЙНАХ КАК СЮЖЕТ В ЛИТЕРАТУРЕ И ИСКУССТВЕ XVI ВЕКА, "Средние века"
Authors: Сошникова К.В.
Published: October 2022

Статья посвящена восприятию во французской литературе и рукописных книгах XVI в. образа французских королей Людовика XII и Франциска I, на формирование которого повлияло участие этих королей в Итальянских войнах. Составление итинерария правителей предполагает изучение их передвижения и маршрутов, а также влиявших на них факторов. Однако то, как монархи хотели видеть свои путешествия, и то, как их видели другие, представляет образ, созданный в соответствии с желанием заказчика и восприятием мастера. Поэтому в статье речь идет о воображаемом путешествии монарха на страницах французских рукописей.
Impact of Moisture Conservation Practices, Seed Inoculation and Zinc Level on Growth and Yield of Chickpea (Cicer arietinum L.)
Authors: Kumar Kishan , Pyare Ram , Verma V. K. , Sachan Ravindra , Niwas Ram , Yadav Ankit , Pal Ravikesh Kumar , Ranjan Abhishek Raj
Published: October 2022

A field experiment was conducted during the Rabi season of 2020-21 and 2021-22. The experiment was laid out in split-split plot design with 27 treatment combination comprising of three moisture conservation practices viz. flat bed with 2.5 t/ha crop residue, narrow bed and furrow with 2.5 t ha-1 crop residue and broad bed and furrow with 2.5 t ha-1 crop residue in main plot and three seed inoculation viz. control, rhizobium and PSB in sub plot with three zinc level viz. control, 2.5 kg Zn ha-1 and 5.0 kg Zn ha-1 in sub-sub plot. Result shows that the broad bed and furrow with 2.5 t ha-1 crop residue produced significantly all growth parameters and yields attributes as compare to flat bed with 2.5 t ha-1 crop residue and narrow bed and furrow with 2.5 t ha-1 crop residue, respectively. The all growth parameters and yields attributes were significantly recorded higher under seed inoculation with rhizobium over PSB and control. The application of different dose of zinc produced marked significant variation in growth parameter and yield attributes when it increased up to 5.0 kg Zn ha-1. The highest yields were significantly receive in broad bed and furrow with 2.5 t ha-1 crop residue over narrow bed and furrow with 2.5 t ha-1 crop residue and flat bed with 2.5 t ha-1 crop residue, respectively with percent increment 16.33, 24.65, 11.47 and 7.16 in respect of biological yield, grain yield, stover yield and harvest index, respectively over control in pooled data. Seed inoculation with rhizobium produced significantly higher yields parameter over control and PSB with percent increment 5.37, 7.72, 3.84 and 2.34 in biological yield, grain yield, stover yield and harvest index, respectively over control. Application of 5.0 kg Zn ha-1 were produced significantly higher yields with percent increment 6.24, 7.25, 5.56 and 1.01 over control in respect of biological yield, grain yield, stover yield and harvest index, respectively. Therefore, broad bed and furrow with 2.5 t ha-1 crop residue and rhizobium inoculation with dose of 5.0 kg Zn ha-1 were significantly superior in respect to growth and yield attributes and yields of chickpea in present investigation.
Impact of Non‐Muscle Cells on Excitation‐Contraction Coupling in the Heart and the Importance of In Vitro Models
Authors: Belanger Kirstie , Koppes Abigail N. , Koppes Ryan A.
Published: October 2022

Excitation‐coupling (ECC) is paramount for coordinated contraction to maintain sufficient cardiac output. The study of ECC regulation has primarily been limited to cardiomyocytes (CMs), which conduct voltage waves via calcium fluxes from one cell to another, eliciting contraction of the atria followed by the ventricles. CMs rapidly transmit ionic flux via gap junction proteins, predominantly connexin 43. While the expression of connexin isoforms has been identified in each of the individual cell populations comprising the heart, the formation of gap junctions with nonmuscle cells (i.e., macrophages and Schwann cells) has gained new attention. Evaluating nonmuscle contributions to ECC in vivo or in situ remains difficult and necessitates the development of simple, yet biomimetic in vitro models to better understand and prevent physiological dysfunction. Standard 2D cell culture often consists of homogenous cell populations and lacks the dynamic mechanical environment of native tissue, confounding the phenotypic and proteomic makeup of these highly mechanosensitive cell populations in prolonged culture conditions. This review will highlight the recent developments and the importance of new microphysiological systems to better understand the complex regulation of ECC in cardiac tissue.
Grid‐responsive smart manufacturing: A perspective for an interconnected energy future in the industrial sector
Authors: Billings Blake W. , Powell Kody M.
Published: October 2022

With the growing amount of renewable energy sources, the grid has become responsible for accounting for intermittency and the flexibility needed to utilize dynamic sources. Expensive peaking plants and energy storage systems have been proposed as ways to mitigate those problems. There is a large group of energy consumers that can respond to grid conditions. Historically, these consumers have been residential and commercial users, but with modern innovations and practices, industrial consumers have the potential to become a major player in this space. Grid‐responsive smart manufacturing can be used to utilize modern tools in manufacturing innovation as enablers for grid response. These modern tools already exist but are not widely used for industrial grid‐side energy management. This article defines grid‐responsive smart manufacturing, identifies five major barriers to its widespread implementation, and portrays the path to getting industrial users to be key players in grid stability and flexibility.
Integrative genomic and transcriptomic profiling reveals distinct molecular subsets in adult mixed phenotype acute leukemia
Authors: Wang Qian , Cai Wen‐zhi , Wang Qin‐rong , Zhu Ming‐qing , Yan Ling‐zhi , Yu Yan , Bao Xie‐bing , Shen Hong‐jie , Yao Hong , Xie Jun‐dan , Zhang Tong‐tong , Zhang Ling , Xu Xiao‐yu , Shan Zhe , Liu Hong , Cen Jian‐nong , Liu Dan‐dan , Pan Jin‐lan , Lu Da‐ru , Chen Jia , Xu Yang , Zhang Ri , Wang Ying , Xue Sheng‐li , Miao Miao , Han Yue , Tang Xiao‐wen , Qiu Hui‐ying , Sun Ai‐ning , Huang Jin‐yan , Dai Hai‐ping , Wu De‐pei , Chen Su‐ning
Published: October 2022

Mixed phenotype acute leukemia (MPAL) is a subtype of leukemia in which lymphoid and myeloid markers are co‐expressed. Knowledge regarding the genetic features of MPAL is lacking due to its rarity and heterogeneity. Here, we applied an integrated genomic and transcriptomic approach to explore the molecular characteristics of 176 adult patients with MPAL, including 86 patients with T‐lymphoid/myeloid MPAL (T/My MPAL‐NOS), 42 with Ph+ MPAL, 36 with B‐lymphoid/myeloid MPAL (B/My MPAL‐NOS), 4 with t(v;11q23), and 8 with MPAL, NOS, rare types. Genetically, T/My MPAL‐NOS was similar to B/T MPAL‐NOS but differed from Ph+ MPAL and B/My MPAL‐NOS. T/My MPAL‐NOS exhibited higher CEBPA, DNMT3A, and NOTCH1 mutations. Ph+ MPAL demonstrated higher RUNX1 mutations. B/T MPAL‐NOS showed higher NOTCH1 mutations. By integrating next‐generation sequencing and RNA sequencing data of 89 MPAL patients, we defined eight molecular subgroups (G1–G8) with distinct mutational and gene expression characteristics. G1 was associated with CEBPA mutations, G2 and G3 with NOTCH1 mutations, G4 with BCL11B rearrangement and FLT3 mutations, G5 and G8 with BCR::ABL1 fusion, G6 with KMT2A rearrangement/KMT2A rearrangement‐like features, and G7 with ZNF384 rearrangement/ZNF384 rearrangement‐like characteristics. Subsequently, we analyzed single‐cell RNA sequencing data from five patients. Groups G1, G2, G3, and G4 exhibited overexpression of hematopoietic stem cell disease‐like and common myeloid progenitor disease‐like signatures, G5 and G6 had high expression of granulocyte‐monocyte progenitor disease‐like and monocyte disease‐like signatures, and G7 and G8 had common lymphoid progenitor disease‐like signatures. Collectively, our findings indicate that integrative genomic and transcriptomic profiling may facilitate more precise diagnosis and develop better treatment options for MPAL.
Aqueous in‐situ electrosynthesis and electrochromic performance of PEDOT:PSS/Reline film
Authors: Wu Wei , Zeng Hailan , Zhang Weiran , Zhang Weili , Jiang Haiyun , Wu Guohua , Li Ziyu , Wang Xiang , Huang Yiyang , Lei Zhiyong
Published: October 2022

Poly(3,4‐ethylene dioxythiophene) (PEDOT) is a promising electrochromic material in many practical application, such as smart windows and displays. However, there are still difficulties in currently realizing green manufacturing, high coloration efficiency, and rapid response. Herein, in‐situ electrochemical polymerization of PEDOT:PSS/Reline films was suggested in aqueous solution. Deep eutectic solvents (DES) composed of choline chloride and urea (Reline) were employed as green solvents in reaction system and used as dopants for the PEDOT:PSS. The as‐prepared PEDOT:PSS/Reline films exhibited remarkable electrochromic properties, including great ion diffusion coefficient, fast reaction time (coloration response time was 1.4 s), prominent transmittance modulation (38%), high coloration efficiency (223 cm2/C) and excellent cyclic stability. Impressively, doping of Reline cannot only provide a green polymerization environment, but also significantly boost the electrochromic properties.
CrosslinkedPMIAultrafiltration membrane with enhanced permeability via incorporatingTMCmonomer
Authors: Gao Ling‐Lin , Li Ping‐Ping , Li Hua‐Xiang , Fang Yin‐Xin , Lin Yu‐Fei , Zhan Zi‐Ming , Xu Zhen‐Liang
Published: October 2022

A trade‐off behavior is noteworthy between protein rejection and pure water flux (PWF) for ultrafiltration membranes; it is recommendable to increase flux without reducing selectivity. The poly (meta‐phenylene isophthalamide) (PMIA) ultrafiltration membrane was modified via incorporating 1,3,5‐benzene tricarboxylic chloride (TMC) to optimize the performance for the first time. Molecular dynamics (MD) simulation was applied to probe the mechanism of the effects of the concentrations of cosolvent LiCl and addition TMC on the dissolving process. It was turned out that a suitable concentration of TMC in the dope solution markedly enhanced the PWF (from 276.22 to 566.20 m−2 h−1 bar−1) with an increasing bovine serum albumin rejection (from 92.05% to 94.64%). Besides, the optimized membrane also possesses excellent anti‐fouling and mechanical performance. These improvements can be due to the crosslinking between PMIA and TMC and enlarged average pore diameter. This work broadens the application of PMIA and TMC in ultrafiltration and provides a novel methodology for PMIA modification.
Bioenergy research in Brazil: A bibliometric evaluation of the BIOEN research program
Authors: Souza Roney Fraga , Miranda Júlio Cesar de Carvalho , da Silva Júnior Jaim José , da Silveira José Maria
Published: October 2022

This article discusses the scientific production carried out by the largest bioenergy research program in Brazil, the São Paulo Research Foundation Bioenergy Research Program (BIOEN‐FAPESP), in the period from 2008 to 2019. The study draws on a list of BIOEN publications on the Web of Science (WoS) platform, containing over 1000 articles, grouped under ResearcherID H‐6149‐2012. The methods applied in the study were based on the information specific to each article and involved the construction of networks including authors, countries, research subjects, and direct citations. Communities were built based on network properties and their content was extracted from articles abstracts, titles and keywords, using text mining techniques. We also obtained quantitative measures for BIOEN scientific output. The analysis found that BIOEN produced relevant knowledge, and contributed to the emergence of new research areas in the bioenergy sector. Overall, BIOEN was decisive for the advancement of bioenergy research in Brazil, and resulted in the expansion of the knowledge base for ethanol production. © 2022 Society of Chemical Industry and John Wiley & Sons, Ltd.
Losing a child to adolescent cancer: A register‐based cohort study of psychotropic medication use in bereaved parents
Authors: Hovén Emma , Ljungman Lisa , Sveen Josefin , Skoglund Charlotte , Ljungman Gustaf , Ljung Rickard , Wikman Anna
Published: October 2022

Purpose

To investigate the short‐ and long‐term risk of psychotropic medication use in parents who lose a child to cancer diagnosed in adolescence.

Methods

This is a Swedish nationwide register‐based study including 184 bereaved mothers and 184 bereaved fathers of 184 children diagnosed with cancer in adolescence. Logistic regression analyses, adjusted for sociodemographic characteristics and history of mental health problems, were performed to estimate risk of a prescription of psychotropic medication (anxiolytics, hypnotics/sedatives, antidepressants) in cancer‐bereaved parents from 1 year before to 5 years after the child's death, with a general population sample of non‐bereaved parents (n = 3291) as referents.

Results

At the year of the child's death, 28%–36% of mothers and 11%–20% of fathers had a prescription of anxiolytics, hypnotics/sedatives or antidepressants. The corresponding percentages for non‐bereaved mothers and fathers were 7%–12% and 4%–7%, respectively. Compared to non‐bereaved mothers, bereaved mothers showed higher odds of prescriptions from 1 year before up to four (anxiolytics) and 5 years (hypnotics/sedatives and antidepressants) after the child's death. Bereaved fathers showed higher odds than non‐bereaved fathers of prescriptions from 1 year before up to the year of (anxiolytics and hypnotics/sedatives) and 1 year after (antidepressants) the child's death. No differences in odds between bereaved and non‐bereaved fathers were found at 2 years after the child's death. Being unmarried, born outside Sweden, and having a history of mental health problems were associated with higher odds of prescribed medications.

Conclusions

Indicative of mental health problems of clinical importance, cancer‐bereaved parents had a higher prevalence of use of psychotropic medication. A decrease in medication use was evident with time, but still at 5 years after the child's death mothers displayed a higher use while fathers showed no difference to non‐bereaved fathers after 2 years.
Nodular hepatic lesion mimicking gallbladder carcinoma in myeloma
Authors: Takatsuka Keiko , Matsumoto Masanori , Takakuwa Teruhito
Published: October 2022

An 81‐year‐old man was diagnosed with nodular hepatic lesion of extramedullary plasmacytoma with the absence of FDG uptake. Doppler ultrasonography showed pulsations and abundant blood flow signals within the tumor. The blood flow was temporally reduced after daratumumab‐based induction therapy; however, the tumor rapidly re‐expanded with blood reflow.
Massive anorectal abscess caused by rectal cancer
Authors: Hirata Risa , Tago Masaki , Aihara Hidetoshi
Published: October 2022

A 66‐year‐old man with perianal pain was found to have a tender erythematous mass on the left side of the anus. Thoracoabdominal computed tomography with contrast enhancement showed a massive anorectal abscess extending from the rectum to the perianal area. The final diagnosis was anorectal abscess caused by rectal cancer.
Case report on psychogenic nonepileptic seizures: A series of unfortunate events
Authors: Udofia Aniebiot‐Abasi , Rocke Tamarie
Published: October 2022

Psychogenic nonepileptic seizures, also called Functional Seizures, are a highly disabling form of Functional Neurological Disorder. The diagnosis of PNES could be missed in clinical scenarios where patients exhibit concurrent musculoskeletal/neurological findings. Characterization of convulsions and judicious use of diagnostics are equally valuable in establishing the diagnosis.
A Closed Loop Wastewater Biorefinery Based on the Recently Introduced SHEFROL Reactor and Two Freely Available Macrophytes
Authors: Tabassum‐Abbasi  , Patnaik Pratiksha , Abbasi Shahid Abbas
Published: October 2022

With an objective to develop a closed loop wastewater biorefinery, the performance of two free floating aquatic weeds water hyacinth (Eichhornia crassipes, Mart, Solms) and salvinia (Salvinia molesta, Mitchell) is explored when either is used as the main bioagent for treating sewage in “sheet flow root level” (SHEFROL) bioreactors. Both the macrophytes prove to be easy to propagate and maintain while they are able to help in achieving significant primary, secondary, and tertiary treatment steps of greywater in a single step. Water hyacinth is able to remove suspended solids, chemical oxygen demand (COD), biological oxygen demand (BOD), total Kjeldahl nitrogen, soluble phosphorous, zinc, copper, nickel, and manganese to the average extents of 81%, 79%, 43%, 41%, 40%, 36%, 34%, and 29%, respectively. The reduction in COD and BOD levels achieved by salvinia is marginally lesser than by water hyacinth but in terms of the removal of other pollutants, the performance of salvinia is comparable to that of water hyacinth. It is possible to convert the dead or harvested plants to organic fertilizer thus making it a closed‐loop system with no waste of its own.
Never stop wondering: When cells become PAP‐art on the slides
Authors: Lombardo Vittoria , Cartesio Stefania , Fadda Guido , Rossi Esther Diana
Published: October 2022

The project named Victoria’s cells was created to train health care personnel, especially in low‐income countries. This innovative approach is designed to associate benign and malignant cellular images and/or patterns with a range of shapes and color shades to evoke animals, common objects, and colorful aquariums. The project makes use of familiar images to capture the viewer’s interest as an aid for cytological interpretation. Cervicovaginal cytology is processed with conventional and liquid‐based cytology. The images are visually compelling to highlight the importance of studying cells and their diagnostic significance. Infectious diseases as well as malignant cells are thereby easily recognized. The pictures are organized into different sections, including Victoria’s zoo, Victoria’s fantasy, and malignant mockery. Branching mycelia resemble a starfish; squamous metaplasia recalls a sea turtle’s shell. Among others, different patterns of endometrial, endocervical, and squamous cells can resemble fish tanks populated by cells with the shapes of pufferfish, anglerfish, whales, scorpions, and garfish. The sea transitions to the earth, with a sly cat, a little elephant, a dog, and a koala. Other cellular preparations resemble a gymnast, a geisha, and a plunging diver as well as hummingbirds, a heron, a water lily, and a peony. The malignant mockery section is composed of squamous intraepithelial lesion patterns that resemble monsters, eyes, a foul tongue, eagles, and feathers. In conclusion, the recognition of visual images can make the study of cytology simpler and more enjoyable and serve the final objectives of prevention and cure.
Farewell and thank you, from the editor
Authors: Hope Joan
Published: October 2022

Matriculation and commencement are part of the pattern of the year for enrollment managers. I have spent longer as editor of Enrollment Management Report than your institution's students spend at your school (at least I hope none of them stay so long) — 16 and a half years! But after this issue, it's time for new adventures. I'm thinking of the change as my commencement.
Combining sodium MRI, proton MR spectroscopic imaging, and intracerebral EEG in epilepsy
Authors: Azilinon Mikhael , Makhalova Julia , Zaaraoui Wafaa , Medina Villalon Samuel , Viout Patrick , Roussel Tangi , El Mendili Mohamed M. , Ridley Ben , Ranjeva Jean‐Philippe , Bartolomei Fabrice , Jirsa Viktor , Guye Maxime
Published: October 2022

Whole brain ionic and metabolic imaging has potential as a powerful tool for the characterization of brain diseases. We combined sodium MRI (23Na MRI) and 1H‐MR Spectroscopic Imaging (1H‐MRSI), assessing changes within epileptogenic networks in comparison with electrophysiologically normal networks as defined by stereotactic EEG (SEEG) recordings analysis. We applied a multi‐echo density adapted 3D projection reconstruction pulse sequence at 7 T (23Na‐MRI) and a 3D echo‐planar spectroscopic imaging sequence at 3 T (1H‐MRSI) in 19 patients suffering from drug‐resistant focal epilepsy who underwent presurgical SEEG. We investigated 23Na MRI parameters including total sodium concentration (TSC) and the sodium signal fraction associated with the short component of T2* decay (f), alongside the level of metabolites N‐acetyl aspartate (NAA), choline compounds (Cho), and total creatine (tCr). All measures were extracted from spherical regions of interest (ROIs) centered between two adjacent SEEG electrode contacts and z‐scored against the same ROI in controls. Group comparison showed a significant increase in f only in the epileptogenic zone (EZ) compared to controls and compared to patients' propagation zone (PZ) and non‐involved zone (NIZ). TSC was significantly increased in all patients' regions compared to controls. Conversely, NAA levels were significantly lower in patients compared to controls, and lower in the EZ compared to PZ and NIZ. Multiple regression analyzing the relationship between sodium and metabolites levels revealed significant relations in PZ and in NIZ but not in EZ. Our results are in agreement with the energetic failure hypothesis in epileptic regions associated with widespread tissue reorganization.
Aortic regurgitation: A multimodality approach
Authors: Siani Agnese , Perone Francesco , Costantini Pietro , Rodolfi Sara , Muscogiuri Giuseppe , Sironi Sandro , Carriero Serena , Pavon Anna Giulia , van der Bilt Ivo , van Rosendael Philippe , Broekhuizen Lysette , Teske Arco , Cramer Maarten Jan , Guglielmo Marco
Published: October 2022

Aortic regurgitation (AR) is a common valvular pathology. Multimodality noninvasive cardiovascular imaging is routinely used to assess the mechanism of AR, degree, and its hemodynamic impact on the cardiovascular system. Collecting this information is crucial in establishing the prognosis and in guiding patient management and follow‐up. While echocardiography remains the primary test to assess AR, a comprehensive assessment of this valvulopathy can be obtained by combining the information from different techniques. This state‐of‐the‐art review is intended to provide an update ed overview of the applications, strengths, and limits of transthoracic echocardiography, cardiac magnetic resonance, and cardiac computed tomography in patients with AR.
Role of different echocardiographic modalities in the assessment of microvascular function in women with ischemia and no obstructive coronary arteries
Authors: Jovanovic Ivana , Tesic Milorad , Djordjevic‐Dikic Ana , Giga Vojislav , Beleslin Branko , Aleksandric Srdjan , Boskovic Nikola , Petrovic Olga , Marjanovic Marija , Vratonjic Jelena , Paunovic Ivana , Ivanovic Branislava , Trifunovic‐Zamaklar Danijela
Published: October 2022

This review summarizes current knowledge about echocardiographic modalities used to assess microvascular function and left ventricular (LV) systolic function in women with ischemia and no obstructive coronary arteries (INOCA). Although the entire pathophysiological background of this clinical entity still remains elusive, it is primarily linked to microvascular dysfunction which can be assessed by coronary flow velocity reserve. Subtle impairments of LV systolic function in women with INOCA are difficult to assess by interpretation of wall motion abnormalities. LV longitudinal function impairment is considered to be an early marker of subclinical systolic dysfunction and can be assessed by global longitudinal strain quantification.
Clinical prediction of magnetic resonance image compilation in patients with mild cognitive impairment
Authors: Sui Haijing , Yang Juan , Yan Chenggong
Published: October 2022

This study aims to investigate the clinical prediction of magnetic resonance image compilation (MAGiC) and magnetic resonance image (MRI) in early diagnosis of the patients with mild cognitive impairment. This study is a retrospective randomized controlled clinical trial, and all patients are divided into following two groups: experiment group and control group. Patients in the experiment group are detected by MAGiC, and patients in the control group are detected by MRI; the clinical material from the two groups of patients with MCI are collected, and then Wechsler Memory Scale‐Logical Memory (WMS‐LM) and Mini‐Mental State Examination (MMSE) are recorded by follow‐up. Images by MAGiC have higher accuracy and definition compared with those by MRI. WMS‐LM score and MMSE score in the experiment group are significantly better than those in the control group. We can conclude that MAGiC is a promising way to evaluate the clinical prediction in patients with MCI.
Coexistence of TEMPI syndrome and leukocytoclastic vasculitis successfully treated with autologous stem cell transplantation
Authors: Nappi Davide , Tauber Martina , Sykes David
Published: October 2022

The TEMPI syndrome is a very rare paraneoplastic syndrome associated with plasma cell dyscrasia and monoclonal gammopathy. First described in 2011, the pathophysiology of TEMPI syndrome is still unknown. Essential for diagnosis is to recognize the five clinical findings: telangiectasias, erythrocytosis and elevated serum erythropoietin, monoclonal gammopathy, perinephric fluid collection, and intrapulmonary shunting. Here we report a case of a woman with the coexistence of TEMPI and leukocytoclastic vasculitis, shedding light on a possible common inflammatory pathway involved in the pathogenesis of the syndrome.
The Value of Contrast‐Enhanced Ultrasound in the Detection of Sentinel Lymph Nodes in Malignant Melanoma
Authors: Deng Xiao‐hong , Du Zhong‐shi , Wu Zhou‐gui , Chen Yu , Wu Xian‐yi , Tang Li‐na
Published: October 2022

Objective

To evaluate the location and characterization value of contrast‐enhanced ultrasound (CEUS) in the detection of sentinel lymph nodes (SLNs) in malignant melanoma.

Methods

SLNs and the lymph node network were tracked by subcutaneous injection of ultrasonic contrast agent around the tumor and preoperative localization, and qualitative analyses were performed. The SLNs were also detected by the intraoperative subcutaneous injection of carbon nanoparticles, and the findings were compared with lymph nodes located by CEUS. The accuracy of the preoperative lymph node identification was evaluated by the results of postoperative pathology, which served as the gold standard of detection.

Results

In 47 patients with malignant melanoma, the mean number of SLNs detected by CEUS was 1.72 ± 0.10, while that by carbon nanoparticle administration it was 1.79 ± 1.07 (P = .371 > .05). Seven cases of lymph node metastasis were detected by CEUS, with a sensitivity of 70.0%, specificity of 97.3%, positive predictive value of 87.5%, negative predictive value of 92.3%, and accuracy of 91.5%. There was high consistency between the findings of CEUS and pathology in differentiating benign and malignant lymph nodes (kappa = 0.726, χ2 = 25.243, P < .001).

Conclusions

CEUS can localize and differentiate SLNs in malignant melanoma, and thus, may potentially guide clinical treatment in the future.
Titrimetric‐comparable BN results determined for in‐service lubricants using quantitative FTIR spectroscopy
Authors: van de Voort Frederik , Furness Daniel , Viset Michael
Published: October 2022

A new stoichiometric FTIR Base Number (BN) method of significant utility and analytical benefit to the tribology sector has been developed, providing ASTM D4739‐comparable BN results in lieu of titration in a fraction of the time. Thirty‐six new/in‐service oils analysed by both methods were linearly related with a between‐method accuracy of ~±1.0 BN and a within‐FTIR method reproducibility of ~±0.50 BN. Acid pKa differences and the comparative similarity of the FTIR results to HCl titration are discussed, including analytical benefits. It provides a rapid means of producing quality ASTM‐comparable results, taking ~1 min/sample for spectral analysis versus 30–40 min for potentiometric titration. Method protocols are best suited to an open architecture FTIR accessory but can be readily adapted to flow cell equipped FTIRs. As structured, ASTM‐like results are obtained rapidly with a major analytical environmental/maintenance footprint reduction, being ideally suited for in‐service lubricant or research labs analysing 20–50 samples/day.
Generating series for the E‐polynomials of GL(n,C)$GL(n,{\mathbb {C}})$‐character varieties
Authors: Florentino Carlos , Nozad Azizeh , Zamora Alfonso
Published: October 2022

With , let be the G‐character variety of a given finitely presented group Γ, and let be the locus of irreducible representation conjugacy classes. We provide a concrete relation, in terms of plethystic functions, between the generating series for E‐polynomials of and the one for , generalizing a formula of Mozgovoy–Reineke. The proof uses a natural stratification of coming from affine GIT, the combinatorics of partitions, and the formula of MacDonald–Cheah for symmetric products; we also adapt it to the so‐called Cartan brane in the moduli space of Higgs bundles. Combining our methods with arithmetic ones yields explicit expressions for the E‐polynomials, and Euler characteristics, of the irreducible stratum of ‐character varieties of some groups Γ, including surface groups, free groups, and torus knot groups, for low values of n.
Characterizing the variability and meteorological drivers of wind power and solar power generation over Africa
Authors: Bloomfield Hannah C. , Wainwright Caroline M. , Mitchell Nick
Published: October 2022

Sub‐Saharan Africa (SSA) has the lowest energy access rates in the world, which poses a key barrier to power system development. Deployment of renewables, including wind and solar power, will play a key role in expanding electricity supply across SSA: distributed generation (enabling access for remote communities), cost‐effectiveness and low emissions are key advantages. However, renewable generation is weather dependent; therefore, including more renewables increases the amount of meteorologically driven variability in the power system. Two countries in SSA are chosen for detailed investigation of this meteorologically driven variability: Senegal in West Africa and Kenya in East Africa. These are chosen due to being areas of dense population, where there is operational wind and solar power, and plans for regional expansion. In Senegal, solar generation is fairly consistent throughout the year, while wind generation exhibits strong seasonality, with a peak in the boreal spring. Low wind and solar power generation days during the boreal summer are found to be related to the passage of African Easterly Waves. Over Kenya, both wind and solar generation exhibit seasonal variability, with wind generation peaking during boreal autumn, and solar generation at a minimum during boreal summer. Inter‐annual variability in generation is greater over Kenya than over Senegal; the El Nino Southern Oscillation is found to impact wind and solar generation over Kenya. El Nino phases are associated with lower wind and solar generation in October–December over Kenya, but higher generation in July–September. This improved understanding of variability will assist system planners in designing reliable future energy systems.
Interaction of the Silver(I) Cation with [2.2]Paracyclophane: Experimental and Theoretical Study
Authors: Vaňura Petr , Sýkora David , Uhlíková Tereza
Published: October 2022

Electrospray ionization mass spectrometry was used to investigate the cation‐π interaction of Ag+ cation with [2.2]paracyclophane. It was found that cationic Ag.([2.2]paracyclophane)+ and Ag.([2.2]paracyclophane)2+ complex species are formed in the gas phase. Further, applying quantum mechanical calculations in the frame of the density functional theory, using B3LYP functional with Def2TZVP basis set, the most probable structures of the proved Ag+ ‐ [2.2]paracyclophane complexes were derived. In the Ag.([2.2]paracyclophane)+ complex, the cation Ag+ is bounded to three carbon atoms of one benzene ring of [2.2]paracyclophane ligand via cation‐π interaction. Quite analogously is bonded also second [2.2]paracyclophane molecule in Ag.([2.2]paracyclophane)2+ complex. The interaction energy, E(int), of Ag.([2.2]paracyclophane)+ complex was calculated to be −220.79 kJ/mol, E(int) of Ag.([2.2]paracyclophane)2+ complex is −362.67 kJ/mol. It is consistent with the formation of the considered Ag+ ‐ [2.2]paracyclophane complex species.
Microgravity Removes Reaction Limits from Nonpolar Nanoparticle Agglomeration
Authors: Pyttlik Andrea , Kuttich Björn , Kraus Tobias
Published: October 2022

Gravity can affect the agglomeration of nanoparticles by changing convection and sedimentation. The temperature‐induced agglomeration of hexadecanethiol‐capped gold nanoparticles in microgravity (µ g) is studied at the ZARM (Center of Applied Space Technology and Microgravity) drop tower and compared to their agglomeration on the ground (1 g). Nonpolar nanoparticles with a hydrodynamic diameter of 13 nm are dispersed in tetradecane, rapidly cooled from 70 to 10 °C to induce agglomeration, and observed by dynamic light scattering at a time resolution of 1 s. The mean hydrodynamic diameters of the agglomerates formed after 8 s in microgravity are 3 times (for low initial concentrations) to 5 times (at high initial concentrations) larger than on the ground. The observations are consistent with an agglomeration process that is closer to the reaction limit on thground and closer to the diffusion limit in microgravity.
Vergleich vakuumbasierter Dichtheitsprüfmethoden
Authors: Engel Lukas
Published: October 2022

Die wiederholbare und genaue Prüfung der Integrität von Primärverpackungen ist unerlässlich, um die Qualität und Wirksamkeit von pharmazeutischen Produkten zu gewährleisten. Seit Jahrzehnten werden hauptsächlich die Blaubadmethode und das Verfahren des mikrobiellen Eindringens eingesetzt. In jüngster Zeit drängen offizielle Richtlinien wie die USP <1207> auf den Einsatz deterministischer und zerstörungsfreier Methoden. In einer Vergleichsstudie sind die bekannten Studien von Kirsch und Burrel zusammengebracht worden. Mehr als 500 Glasfläschchen wurden mit Defekten (Mikroröhrchen und Glasmikropipetten) präpariert. Die Proben sind neben dem Blaubadtest mit drei vakuumbasierten Dichtheitsprüfmethoden geprüft worden: HeliumLecktest, optische Emissionsspektroskopie und Mass Extraction. Die Studienergebnisse vergleichen die vakuumbasierten Methoden mit dem Blaubadtest und bilden eine Entscheidungshilfe, die Methode zu wechseln und den neuen Richtlinien zu entsprechen.
Immersive virtual reality and passive haptic interfaces to improve procedural learning in a formal training course for first responders
Authors: Calandra Davide , De Lorenzis Federico , Cannavò Alberto , Lamberti Fabrizio
Published: October 2022

One key aspect for the safety and success of first responders’ operations is the compliance, during the intervention, with all the safety procedures and prescribed behaviors. Although real-world simulation exercises are considered as the best way to verify if operators are ready to handle emergency situations, they are not always a viable approach. Firefighting courses, for example, do not usually include this kind of activities, due to the numerous hazards related to deploying controlled fires for the simulation. However, traditional training approaches based on class lessons and multimedia learning material may not be particularly effective for teaching practical skills and procedural behaviors. In this work, the use of a Virtual Reality Training Simulation (VRTS) combined with passive haptic interfaces and a real-time fire simulation logic is investigated as a complement to a traditional video-based training approach used in the context of forest firefighting. The teaching of safety concepts and correct use of individual firefighting tools was selected as a use case, and a user study involving 45 trainees was carried out in the context of an existing training course. One third of the trainees attended the traditional video-based lessons of the course, whereas the remaining ones also took part to a practice training session, half of them with the devised VRTS, the others in the real world. Experimental results showed that the additional use of the devised VRTS improved the trainees’ procedural learning, as well as their motivation and perceived quality of the overall learning experience.
Summer pollen flora in rural and urban central England dominated by nettle, ryegrass and other pollen missed by the national aerobiological network
Authors: Hanson Mary , Petch Geoff , Ottosen Thor-Bjørn , Skjøth Carsten
Published: October 2022

Abundance and diversity of airborne pollen are important to human health and biodiversity. The UK operational network collects airborne pollen from 8 flowering trees, grasses and three weeds using Hirst traps and microscopic identification from urban areas. Knowledge of total pollen diversity and differences between rural and urban zones is limited. We collect environmental DNA (eDNA) from air during summer and autumn over 3 years with mini cyclones from one urban and one rural site. Data are analysed using next generation sequencing and metabarcoding. We find the most common genus, Urtica (57%), is also identified by the national network. The grasses Lolium (10%), Agrostis (2%) and Holcus (1%) are in the national network grouped at family level, while Brassica (2%), Chenopodium (1%), Impatiens (2%), Plantago (4%) and Tilia (7%) are not part of the UK operational network. DNA from 138 genera was identified, where 2% of the sample could not be associated with specific genera. 40% of the sample was classified better using eDNA methods at the genus level, than by optical methods. We calculate Bray–Curtis dissimilarity for the rural and urban zones and find a systematic difference in biodiversity. Overall, this shows airborne DNA reveals more information than methods based on morphological differences. The results also suggest data from sites located in large urban areas will be less representative for less populated rural areas. This presents a dilemma in balancing a network and the associated costs delivering health relevant information to the most populated areas vs. a nation-wide approach.
Distinguishing the Dimensions of the Original Dysfunctional Attitude Scale in an Archival Clinical Sample
Authors: Brown Gary P. , Delgadillo Jaime , Golino Hudson
Published: October 2022

The Dysfunctional Attitude Scale measures depression related enduring beliefs and is one of the central measures of cognitive behavioral (CBT) research and theory. It has been the central marker of etiological claims of CBT, and so any change to the understanding of the composition of the DAS would have potentially far-reaching implications for a large body of literature. We sought to capitalize on advances in psychometric techniques since the original 100-item DAS was last analyzed in a sufficiently large clinical sample to provide a definitive measurement model of this important instrument. Beyond the two dimensions usually found on the shorter forms of the scale, we identified the following subscales: imperatives, cognitive flexibility, and negative expectancy. This richer and more precise DAS structure renews its potential to meet the challenge of predicting who is prone to develop depression or experience a recurrence.
Aerial and underwater drones for marine litter monitoring in shallow coastal waters: factors influencing item detection and cost-efficiency
Authors: Escobar-Sánchez Gabriela , Markfort Greta , Berghald Mareike , Ritzenhofen Lukas , Schernewski Gerald
Published: October 2022

Although marine litter monitoring has increased over the years, the pollution of coastal waters is still understudied and there is a need for spatial and temporal data. Aerial (UAV) and underwater (ROV) drones have demonstrated their potential as monitoring tools at coastal sites; however, suitable conditions for use and cost-efficiency of the methods still need attention. This study tested UAVs and ROVs for the monitoring of floating, submerged, and seafloor items using artificial plastic plates and assessed the influence of water conditions (water transparency, color, depth, bottom substrate), item characteristics (color and size), and method settings (flight/dive height) on detection accuracy. A cost-efficiency analysis suggests that both UAV and ROV methods lie within the same cost and efficiency category as current on-boat observation and scuba diving methods and shall be considered for further testing in real scenarios for official marine litter monitoring methods.
Automated 3D burr detection in cast manufacturing using sparse convolutional neural networks
Authors: Mohammed Ahmed , Kvam Johannes , Onstein Ingrid Fjordheim , Bakken Marianne , Schulerud Helene
Published: October 2022

For automating deburring of cast parts, this paper proposes a general method for estimating burr height using 3D vision sensor that is robust to missing data in the scans and sensor noise. Specifically, we present a novel data-driven method that learns features that can be used to align clean CAD models from a workpiece database to the noisy and incomplete geometry of a RGBD scan. Using the learned features with Random sample consensus (RANSAC) for CAD to scan registration, learned features improve registration result as compared to traditional approaches by (translation error ($$\Delta $$
Δ
18.47 mm) and rotation error($$\Delta 43 ^\circ $$

Δ

43
∘

)) and accuracy(35%) respectively. Furthermore, a 3D-vision based automatic burr detection and height estimation technique is presented. The estimated burr heights were verified and compared with measurements from a high resolution industrial CT scanning machine. Together with registration, our burr height estimation approach is able to estimate burr height similar to high resolution CT scans with Z-statistic value ($$z=0.279$$

z
=
0.279

).
Chondrogenic potential of manganese-loaded composite scaffold combined with chondrocytes for articular cartilage defect
Authors: Wei Li , Qin Shuai , Ye Yulin , Hu Jiawei , Luo Danyang , Li Yusi , Gao Yiming , Jiang Liting , Zhou Qi , Xie Xianfei , Li Ning
Published: October 2022

Cartilage is an alymphatic, avascular and non-innervated tissue. Lack of potential regenerative capacity to reconstruct chondral defect has accelerated investigation and development of new strategy for cartilage repair. We prepared a manganese ion-incorporated natupolymer-based scaffold with chitosan-gelatin by freeze-drying procedure. The scaffold was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scanning electron microscopy, energy dispersive spectroscopy, compressive testing, and analysis of porosity and flexibility. Live/dead assay confirmed the good cytocompatibility of prepared scaffold on rat articular chondrocytes after 10 days and 4 weeks of culture. The manganese-loaded composite scaffold upregulated the expression of chondrogenic-related markers (Sox9, integrin, and Col II) in chondrocytes. Western blot analysis of proteins extracted from chondrocytes grown on scaffolds indicated the signaling pathways of p-Akt and p-ERK1/2 played a key role. Histological analysis following implantation of current composite scaffold loaded with chondrocytes into a rat articular cartilage defect model showed that the scaffolds promoted the formation of collagen II and cartilage repair. These findings suggested the potential of manganese-loaded scaffold to promote new cartilage formation and a promising strategy for articular cartilage engineering application.