bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Kemampuan Membuat Kesimpulan Menggunakan Model Contextual Teaching and Learning Berbasis Education for Sustainable Development
Authors: Ariyanti Eri , Fadly Wirawan , Anwar Muhamad Khoirul , Sayekti Titah
Published: December 2021

Perkembangan di dunia pendidikan saat ini menuntut untuk melatih pengembangan ketrampilan proses pada peserta didik. Ketrampilan proses terdiri atas beberapa bagian salah satunya yaitu kemampuan membuat kesimpulan. Tujuan dilakukannya penelitian ini untuk mengetahui model pembelajaran CTL berbasis ESD apakah berpengaruh terhadap kemampuan membuat kesimpulan. Metode penelitian ini menggunakan jenis penelitian kuantitatif true eksperimental dengan desain pretest-posttest control group design, dalam menganalisis data menggunakan deskriptif kuantitatif dan sampel yang diambil secara random sampling. Teknik pengumpulan data berupa lembar observasi, tes tulis dan angket, sedangkan analisis data berupa uji validitas, uji reliabilitas, uji keterbacaan, uji normalitas, uji homogenitas dan uji t. Berdasarkan hasil penelitian menunjukkan bahwa model CTL berbasis ESD terdapat pengaruh peserta didik dalam membuat kesimpulan, hal ini dapat dilihat perbedaan yang antara penggunaan model pembelajaran CTL berbasis ESD dengan model konvensional dalam kemampuan membuat kesimpulan, serta penggunaan model pembelajaran CTL berbasis ESD lebih baik daripada penggunaan model konvensional dalam pembelajaran. Kemampuan membuat kesimpulan yang memiliki nilai tertinggi yaitu mempertimbangkan sesuatu secara induksi, peserta didik lebih mampu membuat kesimpulan dari khusus ke umum sehingga indikator ini memiliki jumlah peningkatan yang lebih tinggi daripada indikator lainnya. Oleh karena itu guru memiliki peran yang sangat penting dalam membimbing peserta didik untuk membuat kesimpulan.
Efektivitas Model Pembelajaran PDEODE (Predict – Discuss – Explain – Observe – Discuss – Explain) Berorientasi pada Socio Scientific Issue terhadap Kemampuan Observasi Peserta Didik
Authors: Alviaturrohmah Khossy , Niswatul Fauziah Hanin , Aristiawan Aristiawan , Kusumaningrum Aldila Candra
Published: December 2021

Penelitian ini bertujuan untuk mengetahui efektivitas model pembelajaran PDEODE (Predict – Discuss – Explain – Observe – Discuss – Explain) yang berorientasi pada socio scientific issue terhadap kemampuan observasi peserta didik kelas VII di MTsN 4 Ponorogo. Instrumen penelitian ini adalah soal pilihan ganda ang diberikan setelah diterapkannya model pembelajaran PDEODE berorientasi pada socio scientific issue. Data dianalisis dengan uji-t menggunakan aplikasi Mini tab. Berdasarkan hasil penelitian, diketahui bahwa P-value sebesar 0,00. Karena nilai P-value kurang dari 0,05 maka H0 ditolak. Hal ini menunjukkan bahwa model pembelajaran PDEODE berorientasi pada socio scientific issue cukup efektif dalam meningkatkan kemampuan observasi peserta didik kelas VII di MTsN 4 Ponorogo.
Pengaruh Model Pembelajaran Numbered Head Together (NHT) Berbasis STEM dalam Meningkatkan Kemampuan Metakognisi
Authors: Anggraini Lelik Ayu , Arif Syaiful , Muna Izza Aliyatul , Aristiawan Aristiawan
Published: December 2021

Seiring berjalannya waktu Pendidikan adalah investasi masa depan yang tak ternilai. Dimana pendidikan berperan penting dalam pembentukan  suatu perubahan. Dibutuhkan pemanfaatan kemampuan metakognisi dalam memecahkan suatu masalah. Dimana  pembelajaran IPA tidak hanya  pembelajaran pengetahuan dasar dalam menyelesaikan permasalahan yang muncul dalam penerapannya. Dibutuhkan kemampuan metakognisi dimana kemampuan terseburt muncul dalam diri peserta didik. Pada penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaaran dan Efektifitas model pembelajaran Numbered Head Together (NHT) berbasis STEM  dalam meningkatkan kemampuan metakognisi peserta didik kelas VIII di MTs Darul Huda Ponorogo. Pada  penelitian ini menggunakan tes dan angket sebagai instrument pengumpulan data. Berdasarkan hasil penelitian yang diakukan mengunakan model pembelajaran Numbered Head Together (NHT) berbasis STEM berjalan dengan baik dan lancar. Sedangkan peningkatan pembelajaran yang semula menggunakan model pembelajaran konvensional kemudian mengunakan model pembelajaran Numbered Head Together (NHT) berbasis STEM mengalami penigkatan sebanyak 32%. Serta hasil analisis angket yang telah diisi oleh tiap peserta didik bernilai positif dilihat dari perolehan skor yang terdapat dalam angket. Hal tersebut menunjuukan bahwa Numbered Head Together (NHT) berbasis STEM  sangat berpengaruh terhadap peningkatan kemampuan peserta didik.
Peningkatan Kemampuan Refleksi Peserta Didik dengan Penerapan Model STM Berbasis Google Form
Authors: Masruroh Ana Miftachul , Fadly Wirawan , Faizah Ulinnuha Nur , Anwar Muhamad Khoirul
Published: December 2021

Penelitian ini bertujuan untuk mengetahui 1) Keterlaksanaan pembelajaran model STM berbasis google form, 2) Keefektivitas model STM berbasis google form dalam meningkatkan kemampuan refleksi peserta didik di SMP Ma’arif 1 Ponorogo, dan 3) Respons peserta didik model STM berbasis google form. Penelitian ini menggunakan rancangan penelitian kuantitatif Quasi Experimental.dengan sampel yang digunakan dalam penelitian ini yaitu peserta didik kelas VII A (kelas eksperimen ) dan VII B (kelas kontrol) yang dipilih dengan menggunakan teknik random sampling. Hasil penelitian menunjukkan bahwa model pembelajaran STM berbasis google form terbukti dapat meningkatkan kemampuan refleksi peserta didik serta dalam proses pembelajaran berjalan dengan baik. Temuan lain dalam penelitian yaitu: 1) proses pembelajran berjalan dengan baik, 2) nilai hasil belajar kelas eksperimen dalam meningkatkan kemampuan refleksi lebih baik daripada kelas konvensional, dan 3) respons peserta didik baik. Saran dalam penelitian yaitu diharapkan untuk menggunakan model STM berbasis google form karena model ini dapat membangun kemampuan refleksi peserta didik dalam kebenaran dan apa yang ditanyakan dalam  permasalahan.
Efektivitas Model Pembelajaran Learning Cycle 5E dan Pendekatan Science for Sustainability Development Terhadap Kemampuan Membuat Keputusan Peserta Didik SMP
Authors: Saputra Wisnu , Fadly Wirawan , Faizah Ulinnuha Nur , Kusumaningrum Aldila Candra
Published: December 2021

Tujuan utama penelitian ini untuk mengetahui perbedaan dan mencari mana yang lebih baik antara model pembelajaran Learning Cycle 5E dan pendekatan Science for Sustainability Development dengan model pembelajaran Konvensional pada kemampuan membuat keputusan peserta didik SMP Negeri 1 Balong Ponorogo. Penelitian ini merupakan penelitian kuantitatif, dengan metode quasi eksperimen dengan purposive sampling. Sampel penelitian ini peserta didik kelas VII B dan VII E di SMP Negeri 1 Balong. Teknik pengumpulan data dengan tes dan lembar kuisioner yang dianalisis secara deskriptif kuantitatif dan statistik inferensial menggunakan uji-t. Instrumen penelitian ini adalah soal uraian yang diberikan setelah penerapan model pembelajaran Learning Cycle 5E dan pendekatan Science for Sustainability Development. Berdasarkan hasil penelitian diketahui bahwa nilai rata-rata kemapuan membuat keputusan peserta didik pada kelas eksperimen 40,71 dan kemudian meningkat menjadi 72. Hai kesimpulan sil pengolahan data menggunakan uji-t one-tailed dapat dinyatakan bahwa terdapat perbedaan yang signifikan kemampuan membuat keputusan peserta didik antara model pembelajaran Learning Cycle 5E dan pendekatan Science for S ustainability Development dengan model pembelajaran Konvensional. Hal ini menujukkan bahwa model pembelajaran Learning Cycle 5E dan pendekatan Science for Sustainability Development efektif terhadap kemampuan membuat keputusan peserta didik.
Potensi Platelet Rich Plasma (PRP) Untuk Kecantikan Alami Kulit Wanita
Authors: Dewi Elsa Amalia
Published: December 2021

RPlatelet rich plasma merupakan komponen darah produk aktif biologis dengan khasnya yang kaya trombosit. Akhir – akhir ini, platelet rich plasma mendapat pusat perhatian karena potensinya terhadap perawatan kecantikan kulit meskipun perhatian belum penuh karena belum akuratnya jawaban penelitian manfaat platelet rich plasma untuk kecantikan. Penulisan artikel dimaksudkan untuk mendapatkan informasi mengenai potensi platelet rich plasma untuk kecantikan kulit wanita alami. Metode penelitian kali ini menggunakan studi literatur untuk mendapatkan data berupa manfaat – manfaat platelet rich plasma untuk kecantikan terutama untuk kulit. Pada artikel juga menginformasikan fokus utama manfaat platelet rich plasma untuk penyembuhan tulang, ligamen dan lain sebagainya. Sebanyak 13 jurnal yang didapat dalam penelitian ini yang mengungkapkan banyaknya manfaat platelet rich plasma untuk kecantikan, diantaranya untuk peremajaan kulit (remodelling kulit saat terjadi penuaan), mempercepat peningkatan produksi kolagen, augmentasi volume kulit dan masalah kulit lain. Dengan ini, potensi platelet rich plasma kaya akan manfaatnya baik untuk tulang, luka, ataupun kecantikan yang kini bisa menjadi solusi perawatan alami untuk kecantikan kulit wanita. Namun demikian, praktik platelet rich plasma untuk perawatan kecantikan tidak tahan lama dibandingkan dengan operasi plastik.
An Assessment of an Educational Intervention Program Based on the Health Belief Model for Safer Sex Among Female Sex Workers in Selected Districts of Northern Region of Malawi
Authors: Twizelimana Donatien , Muula Adamson Sinjani
Published: December 2021

Background: Pregnant women are at risk of pregnancy if they have unprotected sex, do not use or poorly use contraceptives in the context of penile-vaginal sex. We therefore developed an educational toolkit based on the Health Belief Model (HBM) to assist FSWs to make informed sexual and reproductive decision for safer sex before and/or after heterosexual encounter with their clients. We evaluated the educational intervention programme among FSWs and other stakeholders (nurses and clinicians).Methods:This was a qualitative operational research. We developed an educational tool kit based on the HBM to aid FSWs to make informed decision for safer sex behaviour. We conducted 10 in-depth interviews (IDIs) to identify the components of the educational tool kit, 5 IDIs for modification and refining the tool, and consequently two Focus Group Discussions (FGDs) for consensus building. This process was done in Mzimba North. After the intervention we conducted 6 FGDs with FSWs and 10 IDIs with nurses and clinicians to evaluate the applicability and feasibility of the intervention among female sex workers (FSWs) in Mzimba North, and Nkhata Bay located in Northern region of Malawi.Results:We observed mixed opinions on the components of the educational toolkit. Female sex workers were eager to understand misinformation and misconceptions on contraceptives, right to justice, effectiveness of contraceptives. Female sex workers requested the inclusion of STIs and HIV prevention and economic empowerment in the toolkit. Overall the toolkit and the educational intervention were relevant, feasible, and applicable among the study participants. Conclusion:While several strategies can be used to facilitate the implementation of the evidence based intervention to improve health, our educational intervention program based on the Health Belief Model for safer sex behaviour among female sex workers was found to be feasible and applicable in our study settings. We believe that the intervention may be helpful to address sexual and reproductive health challenges encountered by FSWs in the study sites and elsewhere.
Evaluation of Cytogenetic Alterations of Toxic Gas Exposed Population of Bhopal Having Chronic Kidney Disease
Authors: Samarth Ravindra M , Tiwari Rajnarayan , Modi Gopesh , Soni Kishor K , Banjare ML , Hasan Sharique Ul , Jain Sanjay
Published: December 2021

The industrial disaster of Bhopal in 1984 resulted in widespread morbidity and mortality in the vicinity of the industry and required long-term surveillance for chronic health effects in those affected by the leakage of gas. Although few cytogenetic studies were undertaken to assess genetic damage in survivors of the disaster, no studies are available on cytogenetic damage of toxic gas-exposed populations having chronic kidney disease (CKD). Thus, the present study aimed to evaluate cytogenetic alterations in chronic kidney disease patients who were exposed to leaked gas and to compare it with those who were not exposed to the leaked gas. The cytogenetic alterations were evaluated through chromosomal aberration analysis and micronuclei assay. The study included 608 study participants divided into four groups based on the history of exposure to the leaked gas and the presence or absence of CKD. The results of the study showed no statistically significant difference in cytogenetic damage between gas-exposed and non-exposed patients of CKD. However, significantly higher cytogenetic damage was observed among gas-exposed participants having CKD as compared to gas-exposed participants free from CKD. Thus, to conclude though the cytogenetic alterations were observed in an exposed group it cannot be solely attributed to the gas exposure and the role of other confounders must also be studied.
Implication of Shoreline and Nearshore Morphological Changes on Sediment Budget of Wave-Dominated Chennai Beach, India
Authors: SHETTY ATEETH , KANKARA R. S. , S. DHANALAKSHMI , S. BUCKLE , S. SUBBURAJ
Published: December 2021

The study examines the shoreline (1990-2019) and nearshore morphological changes (seasonal) to understand the littoral drift and sediment budget variability. Shoreline change rate depicts erosion (-0.06 m/yr) in the northern sector and accretion (+0.12 m/yr) in the southern sector. Seasonal nearshore morphological changes from non-monsoon to monsoon period signifies net erosion (-1.8x10^4 m^3 ) in northern sector and net accretion (+2.5x10^4 m^3) in the southern sector. Although the lost sediment during monsoon is regained in non-monsoon period, the quantity of sediment gain is reduced in areas with human interventions. The results of the investigation depict the dominance of littoral drift towards north from February to October, when wave approach from east-southeast to south-southeast direction and southwards from November to January when the wave direction was from east-northeast to east-southeast. The net longshore sediment transport rate estimated during the study period was 2.6x10^5 m^3/year in the northern sector and 1.5x10^5 m^3/year in the southern sector with higher rate attributed to monsoon than the non-monsoon. Sediment budget results in deciphering the causes of erosion (-1.27×10^4 m^3/yr) in northern sector and accretion (3.91×10^4 m^3/yr) in southern sector in the wave-dominated Chennai beach.
Acupuncture Improves Certain Aspects of Sleep in Hematopoietic Stem Cell Transplantation Patients: a Randomized Controlled Trial
Authors: Iskandarani Sarah El , Sun Lingyun , Li Susan Qing , Pereira Gloria , Giralt Sergio , Deng Gary
Published: December 2021

Background

High-dose chemotherapy followed by hematopoietic stem cell transplantation (HSCT) is associated with a high symptom burden including decrease in sleep quality. We conducted a randomized sham-controlled trial (#NCT01811862) to study the effect of acupuncture on sleep quality during HSCT.
Methods

Adult multiple myeloma patients undergoing inpatient and outpatient autologous HSCT were randomized to receive either true or sham acupuncture once daily for 5 days starting the day after chemotherapy. Sleep onset, total sleep time, sleep efficiency percentage, and sleep-onset latency time were assessed using an Actigraphy Sleep Monitor. A multi-variate regression analysis was conducted to compare the average area-under-the-curve of five acupuncture intervention days for each sleep outcome between groups, adjusted by baseline score and inpatient or outpatient chemotherapy stratum.
Results

Over 32 months, 63 patients were enrolled. Participants undergoing true acupuncture experienced a significant improvement in sleep efficiency when compared to sham (-6.70, 95% CI -13.15, -0.25, p=0.042). Subgroup analysis showed that the improvement is more prominent in the inpatient setting (-9.62, 95% CI -18.76, -0.47, p=0.040). True acupuncture produced noticeable yet non-significant improvement in sleep-onset latency times. Between-group differences in other sleep related variables were not statistically significant.
Conclusion

Our data suggest that true acupuncture may improve certain aspects of sleep, including sleep efficiency and possibly sleep-onset latency, in multiple myeloma patients undergoing HSCT. By studying patient reported outcomes in future larger scale studies, acupuncture’s role in improving sleep quality during HSCT treatment can be further elucidated.
What Do Oncology Patients Know and Think About Apitherapy?
Authors: KAVURMACI Mehtap , YILDIZ IDRIS
Published: December 2021

The authors have requested that this preprint be removed from Research Square.
Low-Dose Statins Improve Prognosis of Patients with Ischaemic Stroke Undergoing Intra-Arterial Thrombectomy: A Prospective Cohort Study
Authors: Cui Chaohua , Dong Shuju , Liu Qian , Bao Jiajia , Gao Lijie , Li Yanbo , He Li
Published: December 2021

Background: High-dose statins are recommended as preventive drugs in guidelines for patients with ischaemic stroke undergoing thrombectomy. Not only in clinical practice but also based on large-scale studies, low-dose statins have been widely used and demonstrated to be efficient in Asian populations. However, it remains unknown whether low-dose statin is related to the prognosis of patients with thrombectomy. Can low-dose statins reduce the risk of bleeding at the same time?Methods: We prospectively collected data from patients with acute ischaemic stroke undergoing intra-arterial thrombectomy. Efficacy outcomes were National Institutes of Health Stroke Scale (NIHSS) score improvement at 7 days after admission and a favourable functional outcome (FFO) at 90 days. Safety outcomes were rates of in-hospital haemorrhage events and death within 2 years. Results: We included 256 patients in this study. Compared with the control group, the low-dose statin group had a higher NIHSS improvement rate at 7 days, a higher FFO rate at 90 days and a lower death rate within 2 years. The low-dose statin group had a lower percentage of gastrointestinal haemorrhage. Statin use was significantly related to an improved NIHSS score (p=0.028, OR=1.773) at 7 days and FFO (P<0.001, OR=2.962) at 90 days and to lower death rates (P=0.025, or=0.554) within 2 years.Conclusion: In Asian acute ischaemic stroke patients with intra-arterial thrombectomy, low-dose statin use was significantly related to NIHSS improvement at 7 days, FFO at 90 days and decreased death rates within 2 years.
A Qualitative Study on the Feasibility and Acceptability of Establishing Health Technology Assessment (HTA) in a Low Income Country Setting: The Case of Malawi
Authors: Mfutso-Bengo Joseph , Jeremiah Faless , Kasende-Chinguwo Florence , Ng’ambi Wingston , Nkungula Nthanda , Kazanga-Chiumia Isabel , Juma-Kunyenga Mercy , Chawani Marlen , Chinkhumba Jobiba , Twea Pakwanja , Manthalu Gerald , Nkhoma Dominic , Colbourn Tim , Revill Paul , Sculpher Mark
Published: December 2021

BackgroundThe objective of this study was to assess the feasibility and acceptability of institutionalizing Health Technology Assessment (HTA) in Malawi focusing on the form, scope, capacity and financing requirements for a limited resource setting such as Malawi.MethodsThis study employed a desk review and qualitative research methods. An extensive literature review was conducted on relevant key policy documents, reports and publications to understand the status of HTA in Malawi. The study included one focus group discussion with 7 participants and 12 key informant interviews with key stakeholders selected purposely based on their knowledge and expertise in HTA. ResultsThe study found that partial or informal HTA processes exist and that HTA is practiced without a standardized framework. The partial HTA processes are executed through three structures; Ministry of Health Senior Management Team, Technical Working Groups and Pharmacy and Medicines Regulatory Authority (PMRA) with varying levels of effectiveness. The results revealed that lack of an institutional HTA creates severe shortfalls. This includes partial HTA mechanisms, limited evidence use, especially concerning cost-effectiveness, lack of a standardized framework for technology adoption, donor pressure, lack of resources for the HTA process and technology acquisition, laws and practices that undermine cost-effectiveness considerations. ConclusionInstitutionalizing HTA in Malawi is acceptable and feasible. The results suggest that any HTA institutionalization in the short to medium term could involve strengthening the capacity of PMRA to appraise Cost-effectiveness Analysis (CEAs) within academia and MOH health financing division. Furthermore, rather than creating new HTA institutions, country-specific assessments should precede any specific recommendations for new technology adoptions. A technical capacity in Academic institutions such as Health Economics and Policy Unit (HEPU) at Kamuzu University of Health Sciences (KuHes) can be developed either as “offshore” HTA capacity fully aligned to MOH and executing HTA evidence and knowledge management function in a sub-contractor capacity.Running HeadHealth technology assessment in Malawi
Empathy Alleviates the Learning Burnout of Medical College Students Through Enhancing Resilience
Authors: Wu Wenzhi , Ma Xiao , Liu Yilin , Qi Qiqi , Guo Zhichao , Li Shujun , Yu Lei , Long Qing , Chen Yatang , Teng Zhaowei , Zeng Yong
Published: December 2021

Objective The problem of learning burnout of medical students is becoming prominent, and empathy can play a good predictive role in learning burnout. The present study aimed to investigate the relationship between empathy and learning burnout, as well as the mediation effect of resilience in this relation. Methods A random sample of 588 college students from a key medical university in Yunnan Province was investigated using the Basic Empathy Scale, Learning Burnout Scale, and Connor-Davidson Resilience Scale. All the measures showed good reliability and validity in the present study. Data were analyzed using SPSS 23.0 and Amos 22.0. Results Using structural equation modeling, we tested a conceptual model indicated that: (1) medical students' empathy negatively and significantly predicted learning burnout; (2) medical students' empathy positively predicts mental resilience; (3) resilience of medical students negatively predicts learning burnout; (4) resilience partially mediated the relationship between empathy and learning burnout of medical students, while also controlling for family socioeconomic status.Conclusion These findings highlight the mediating role of resilience in the effect of empathy on learning burnout of medical college students. It may contribute to a better understanding of the effect of empathy. Moreover, it can also provide constructive suggestions for protecting and improve empathy and resilience of medical college students.
Temporal and Spatial Water Quality Assessment for Rivers in Metropolitan Areas Using Multivariate Statistics and Water Quality Indices: A Case Study of the Geumho River, Korea
Authors: Jo Chang Dae , Kim Jung Min , Kim Seong Min , Kwon Heon Gak
Published: December 2021

The Geumho River in South Korea passes through a metropolitan area with a high population density and multiple industrial complexes and, therefore, the water quality of this river is of significance for human health and economic activities. This study aims to assess the water quality of the Geumho River to inform river water quality management and improve pollution control using multivariate statistics and the Korean Water Quality Index (KWQI). Principal component and factor analysis identified those factors related to organic pollutants and metabolism (principal factor 1), and phosphorus and fecal coliform content (principal factor 2). In a cluster analysis, time was considered by distinguishing between seasons (spring, summer, autumn, and winter) and space was considered based on upstream (US), midstream (MS), and downstream (DS) river sections. Seven temporal variables and six spatial variables were extracted from the discriminant analysis (DA) results; the most important water quality variables were high during the spring and summer seasons and in the MS and DS regions. Temporally, the KWQI was highest in winter (70.9) and lowest in spring (59.2), whereas spatially, KWQI values were highest in the US (67.5) and lowest in the MS (56.4) sections. These results indicate that to be most effective, water management interventions in the Geumho River should focus on the urban midstream section and spring seasons.
Chronic Pain And Depressive Symptoms In Chinese Middle-Aged And Older Adults:A Follow Up Study
Authors: Liu Jialin , Chen Zixuan , Yu Yuke , Wang Qin , Liu Xiuxiu , Yuan Ping
Published: December 2021

Objective: This study aimed to analyze the effects of chronic pain on the occurrence of depressive symptoms in Chinese middle-aged and older adults, and to provide a scientific basis for reducing the incidence of depressive symptoms, improving the quality of life in middle-aged and older adults, and reducing the disease burden in the aging population.Methods: a prospective study was conducted to select adults aged 45 years or older from the longitudinal study of China Health and elderly care follow-up survey (Charls) (2015 and 2018). Pain was assessed according to the patient's self exposure, and depression was assessed using the Chinese version of the center for epidemiological research Depression Scale (CES-D). Univariate analysis and binary logistic regression model were used for analysis. Results: The 3-year cumulative incidence of depression in chronic pain patients was 52.4% and the annual incidence was 17.5% in the middle-aged and elderly Chinese population. Univariate analysis showed statistically significant differences in the incidence of depressive symptoms between the different genders, age, residence, education level, marriage, self perceived health status, nocturnal sleep time, number of social activities in the past month, smoking, alcohol consumption, impaired ADL and Medicare insurance coverage. This study, after controlling for demographic characteristics, health status and health behaviors, Different pain conditions remained statistically significant for depression in middle-aged and older adults. Compared with middle-aged and older adults without pain, both Unisomatic pain (OR = 1.388) and Multiple somatic pain (OR= 1.869) increased the risk of depression in the middle-aged and older populations. Conclusion: chronic pain is associated with the risk of depressive symptoms in middle-aged and elderly people, and the incidence of depression in middle-aged and elderly people in China is not optimistic.
Synthesis of Highly Active Si-doped TiO2 Nanotube/SnS Hybrids for Photocatalytic Degradation of Toxic Dyes
Authors: Ma Ning , He Hai-Yan
Published: December 2021

Heterostructures with nanoscale sizes have great superiorities in photocatalytic environment decontaminant because of their efficient interface charge transfer and great surface area. This work reports the facile fabrication of nano-tubular TiO2 and Si-doped TiO2 (NTs) hybridizing SnS nanocrystallites and their high-efficient photocatalytic activity. The fabricated nanostructures show wide light absorption in the UV-visible region. The SBET, light absorption, hydrophilicity, and photo-induced super hydrophilicity were enhanced by Si-doping and SnS modification. Moreover, high-efficient interface charge transfer was produced after the SnS modification and further enhanced by the Si doping because of band structure modulation. Thus, the Si-doped TiO2 nanotubes/SnS heterostructures showed a remarkably enhanced photocatalytic and Fenton-like photocatalytic activities in dye wastewater treatment than the TiO2 NTs. This work suggests potential materials and their facile fabrication process for the photocatalytic application of environmental decontamination.
The Influence of the Oxygen Vacancies on the Pt/TiO2 Single-atom Catalyst – a DFT Study
Authors: Zhang Yongkang , Wang Yuhang , Su Kaibin , Wang Fengping
Published: December 2021

The titanium dioxide (TiO2) surface is suitable as a substrate for single-atom catalysts(SACs). As a common defect on TiO2, oxygen vacancies may have a significant impact on the adsorption and activity of the adatoms. This work aims to investigate whether titanium dioxide containing surface oxygen vacancies is more suitable as a base material for SACs. This paper calculates the changes in the adsorption energy of Pt atom and the energy of the d-band center on the perfect surface and the surface containing oxygen vacancies. Concerning the perfect surface, the surface containing oxygen vacancies fixes the Pt atom more firmly, and increases the center energy of the d-band of Pt, thereby improving the performance of Pt atom as SACs. Consequently, the (110) surface of Rutile TiO2 with oxygen vacancies may be the best substrate for SACs.
Effects of Aerobic, Resistance and Combined Training on Endothelial Function and Arterial Stiffness in Older Adults: Study Protocol for a Systematic Review and Meta-Analysis
Authors: Silva Raphael Silveira Nunes da , Silva Diego , Waclawovsky Gustavo , Schaun Maximiliano Isoppo
Published: December 2021

Introduction: Aging is an independent risk factor for cardiovascular events. It promotes vascular dysfunction which is associated with risk factors for cardiovascular diseases (CVDs). Exercise can modulate vascular function parameters, but little is known about the effects of different modalities of training (aerobic, resistance and combined) on endothelial function and arterial stiffness in older adults. Methods: This systematic review study will include randomized controlled trials (RCTs) selected from the electronic databases MEDLINE (PubMed), Cochrane, LILACS, EMBASE and Web of Science. We will follow the PRISMA guidelines and PICOS framework. Studies involving both male and female older adults (≥60 years old) with or without comorbidities undergoing aerobic, resistance and/or combined training compared to a control group (no exercise) will be eligible. We will use Cochrane Risk of Bias 2 (RoB 2) tool to evaluate the quality of individual studies and GRADE to assess the strength of evidence. Statistical analyses will be conducted with RStudio for Windows (v1.3.959) using R package meta. Discussion: A systematic review and meta-analysis involving data from studies of older adults would deepen our understanding of vascular adaptations to exercise training in this population. It could provide new insights into how health providers can improve patient management and prevention of cardiovascular events in older adults. Systematic Review Registry: The study protocol for this review is awaiting approval for registration in the International Prospective Register of Systematic Reviews (PROSPERO) (ID 42021275451).
Does Local Vancomycin Powder Impregnated with Autogenous Bone Graft and Bone Substitute Decrease the Risk of Deep Surgical Site Infection in Degenerative Lumbar Spine Fusion Surgery? - an Ambispective Study
Authors: Wang Shih-Tien , Chou Po-Hsin , Yao Yu-Cheng , Lin Hsin-Hsian , Liu Chien-Lin , Chang Ming-Chau
Published: December 2021

Background:Deep surgical site infection (DSSI) is one of the most challenging complications in lumbar fusion surgery. Few investigations examined the effect of vancomycin powder mixed with ABG and bone substitutes on preventing DSSI in degenerative lumbar fusion surgeries as well as any interference with bony fusion. The aim of the study was to investigate the effects of autogenous bone graft (ABG) along with bone substitutes as a local vancomycin delivery system on preventing DSSI in lumbar instrumented fusion and compared with those who did not use vancomycin powder.Methods: From January, 2015 through December, 2015, a one-year prospective study using vancomycin powder mixed with ABG and bone substitute for degenerative lumbar fusion surgeries as vancomycin (V) group, 1 gm vancomycin for 2 and 3-level, and 2 gm for more than 3-level instrumentation. From December, 2013 through December 2014, patients received degenerative lumbar fusion surgeries without using vancomycin before the vancomycin protocol were retrospectively enrolled as non-vancomycin (NV) group. Vancomycin concentration was checked at post-operative days 1 and 3 for both the serum and drainage. Patients’ demographic data, microbiology reports, fusion status and functional outcomes were evaluated. Results:One hundred and ten patients were enrolled prospectively in the V group, and 86 for the NV group. After an average 41 months follow-up (range, 36-54), 3 patients (3.48%) developed postoperative DSSIs in the NV group, thereby requiring revision surgeries and parenteral antibiotics treatment versus no DSSIs (0%, 0/100) in the V group. (p=0.048). The postoperative serum vancomycin levels were undetectable and no vancomycin related side effects was encountered. The mean vancomycin concentration of drainage at postoperative days 1 and 3 were 517.96 ± 174.4 and 220.14 ± 102.3 mg/mL, respectively. At final follow-up, there was no statistical difference observed in terms of clinical and radiologic outcomes. Conclusions: Our vancomycin protocol may reduce the incidence of DSSI in degenerative lumbar fusion surgery without affecting bony fusion.
Factors Associated with Uptake of Contraceptives Among HIV Positive Women on Dolutegravir Based Anti-Retroviral Treatment - A Crossectional Survey in Urban Uganda.
Authors: Mbabazi Leah , Nabaggala Mariah Sarah , Kiwanuka Suzanne , Kiguli Juliet , Laker Eva , Kiconco Arthur , Okoboi Stephen , Lamorde Mohammed , Castelnuovo Barbara
Published: December 2021

Background

In May 2018, following the preliminary results of a study in Botswana that reported congenital anomalies in babies born to HIV-positive women taking dolutegravir drug, the WHO issued a teratogenicity alert. However, there are scarce data on the impact of this guidance on contraceptive uptake among women taking dolutegravir. We assessed the uptake of contraceptives in HIV-positive women of reproductive age on dolutegravir regimens.
Methods

We conducted a cross-sectional survey from April 2019 to July 2019 in five government health facilities in central Uganda, where dolutegravir-based regimens were offered as the preferred first-line antiretroviral treatment. We randomly selected 359 non-pregnant women aged 15-49 years taking dolutegravir-based regimens and interviewed them using semi-structured interviewer-administered questionnaires. We collected data on demographics, contraceptive use, individual, social, and health system factors. We described patients’ characteristics using descriptive statistics and assessed factors associated with contraceptive uptake using a modified Poisson regression model.
Results

A total of 359 women were included in the study. The mean age was 37 years (standard deviation=6.8) and overall contraceptive uptake was 38.4%. The most utilized method was injectable method at 58.4% followed by condoms (15%), intrauterine device (10.7%), pills (6.4%), implants (5.4%), and sterilization (0.7%) Predictors for contraceptive uptake were parity of 3-4 children (Adjusted Prevalence Ratio (APR) =1.48, 95% confidence interval (CI): 1.14, 1.92). There was reduced uptake in the age range of 40-49 years (APR=0.45, CI: 0.21-0.94), unemployed (APR: 0.6, CI: 0.42- 0.94), women not discussing family planning with their partner (APR=0.39, CI: 0.29-0.52) and not receiving family planning counseling (APR= 0.56, CI: 0.34-0.92).
Conclusion

We observed a low-level uptake of contraceptives, with injectables as the most used method. Family planning counseling and partner discussion on family planning were associated with contraceptive uptake among the women who used dolutegravir based regimens. There is a need for more strategies to integrate FP services and increase male involvement in HIV care programs.
Breastfeeding Duration and Its Effective Factors in Mothers with Children Aged 30-36 Months in Kerman in 2020
Authors: Mirafzali Sedighe , Sari Ali Akari , alizadeh somayeh
Published: December 2021

Introduction: Complete cessation of breastfeeding (CCB) at the right time is as important as starting breastfeeding, as well as identifying the factors that affect the duration of breastfeeding, so that breastfeeding promotion programs focus on these causes, to increase mothers' ability and desire to breastfeed. This study aimed to determine the time of CCB and its related factors.Methods: This study was a descriptive-analytical and cross-sectional type. A total of 802 urban and rural mothers with children aged from 30 to 36 months completed the questionnaire. The validity and reliability of the questionnaire were confirmed by Cronbach's alpha of 85%. Data were analyzed using SPSS software version 16.Results: The mean time of breastfeeding was 19.23±7.09 and the median was 22-month-year. About 41% of children were breastfed until 24-month-year. There was a significant relationship between the time of cessation of breastfeeding with contraception, number of households, place of residence, and weight at 6-month-year at the level of 0.05.Conclusion: Duration of breastfeeding is influenced by some demographic and cultural factors. The timing of the CCB differs from the suggestions of the World Health Organization (WHO) and religious teachings. Useful interventions are needed to increase the duration of breastfeeding.
Lysine-Functionalized Layered Double Hydroxides For The Antibiotics’ Efficient Removal: Controllable Fabrication Via BBD Model And Removing Mechanism
Authors: Hu Yuying , Liu Susu , Qiu Min , Zheng Xiaohuan , Peng Xiaoming , Dai Hongling , Hu Fengping , Xu Li , Xu GaoPing
Published: December 2021

Ly @ FeZn layered double hydroxides (LDHs) controllable fabrication based on Box-Behnken Design (BBD) model was fabricated, and presented stable and efficient removal performance for Ciprofloxacin (CIP), Norfloxacin (NOR) and Ofloxacin (OFL) removal. It should be noted that Ly @ FeZn had different adsorption behavior towards CIP, NOR and OFL. Furthermore, the Ly @ FeZn was characterized by SEM, XRD, FT-IR and XPS. Results revealed the optimized fabrication condition (temperature of 60 °C, Fe / Zn molar ratio of 0.5 and the lysine dosage of 5.8 mmol) for the removing efficient. The highest adsorption capacity of CIP, NOR and OFL were 193.83, 190.20 and 62.12 mg/g, respectively. Adsorption kinetics of both CIP and NOR were well simulated with the pseudo-first-order kinetic model, while that of OFL was well-described by the pseudo-second-order. Moreover, the adsorption thermodynamics of CIP and NOR on Ly @ FeZn indicated that the adsorption processes were exothermal, feasible and spontaneous. It was worth noting that the adsorption mechanism of Ly @ FeZn for CIP and NOR were the synergistic reaction of electrostatic attraction, chemical bonding and flocculation. On the other side, the adsorption behavior of OFL was relatively low, and the adsorption mechanism was only electrostatic attraction.
Incidence and Prognostic Nomogram for Resected Non-small Cell Neuroendocrine Tumor: A Population-Based Respective Study in China and the SEER Database
Authors: Pang Zhaofei , Liu Yong , Zhao Xiaogang , Ma Guoyuan , Zhao Qidi , Du Jiajun
Published: December 2021

Background: Pulmonary neuroendocrine tumors, including small cell lung cancer (SCLC) and non-small cell neuroendocrine tumor (NSCLC-NET), have obvious heterogeneity. The comparison between SCLC and NSCLC-NET, and prognostic nomogram of resected NSCLC-NET have not been performed.Methods: We retrieved patients’ information with pulmonary neuroendocrine tumors from SEER database. Age-adjusted incidence and prognostic impacts of histological subtypes, surgery strategies and smoking were compared between SCLC and NSCLC-NET. Independent prognostic factors, screened by Cox regression, were enrolled for prognostic nomogram of resected NSCLC-NET. The nomogram were evaluated and compared to the 8th AJCC TNM staging system. A Chinese cohort was used for external validation.Results: Age-adjusted incidence of SCLC declined after 1991 but the incidence of NSCLC-NET continuously rose. Patients with typical carcinoid had the best prognosis in both overall survival and lung cancer specific survival after operation. Sleeve and segmental resection were more recommended in NSCLC-NET and SCLC, respectively. High-smoking index was associated with worse prognosis in both SCLC and NSCLC-NET. Histological subtype, age, surgery type, N, M stage and chemotherapy were independent prognostic factors and used to construct prognostic nomogram of resected NSCLC-NET. The nomogram performed well with good discrimination, calibration and clinical usefulness, which was validated by Chinese cohort (1, 3, 5-year AUC: SEER cohort 0.873, 0.901, 0.875; Chinese cohort 0.867, 0.892, 0.874). Compared to 8th staging system, the nomogram had higher C-index (0.87 vs 0.728, P < 0.001), clinical usefulness, increasing AUC value over time and improved 68%. The online server can be accessed at https://nsclc-net-prognostic-prediction.shinyapps.io/DynNomapp/. Conclusion: NSCLC-NET had increasing incidence over the past decades. The nomogram had high discrimination, calibration and clinical usefulness and performed better than 8th staging system. It may have certain value in risk stratification and survival prediction of patients with resected NSCLC-NET and help clinicians to take measures for high-risk patients in advance.
Coastal Hypoxia Drives Microbial Diversity: Elucidation through 16S rRNA Amplicon Sequencing
Authors: Naik Vruti V , Damare Samir R , Shah Shruti S , Shenoy Damodar M , Mulla Amara Begum
Published: December 2021

The formation of oxygen-depleted zones in the bottom waters is one of the most widespread phenomena in coastal areas. Upwelling episodes occurring along the west coast of India due to the southwest monsoon lead to an increase in biological productivity which further lowers the dissolved oxygen in the upwelled waters, which intensifies annually between June and October. Here, we have determined the changes in the microbial community in response to the varying oxygen levels and other physicochemical parameters at the Candolim Time Series Station using high-throughput sequencing. Amplicon Sequence Variants across all the samples collected in different seasons were mostly affiliated to the phyla Proteobacteria, Actinobacteria, Bacteroidetes, Verrucomicrobia, Chloroflexi, Firmicutes and Planctomycetes, with the most dominant being Proteobacteria (21-41%). Statistical analysis revealed that microbial diversity differed significantly with changing DO, ammonia, nitrate and nitrite concentrations during different seasons. The microbial community shift due to seasonal hypoxia results in the differential biogeochemical cycling of essential nutrients with certain years seeing redox conditions up to sulphate reduction, while certain years seeing only nitrogen loss. Future scenario of global warming will serve as a big challenge for understanding the role of microbial diversity and its implications in the cycling of natural elements.
Beta-adrenergic Receptor Blockade Effects on Cardio-pulmonary Exercise Testing
Authors: Forton Kevin , Lamotte Michel , Gillet Alexis , Chaumont Martin , Philippe Van De Borne , Faoro Vitalie
Published: December 2021

Background: Beta-blockers are increasingly prescribed while the effects of beta-adrenergic receptor blockade on cardio-pulmonary exercise test (CPET) derived parameters remain under-studied. Methods: 21 young healthy adults repeated 3 CPET at an interval of 7 days at the same time of the day. The tests were performed 3 hours after a random, double blind, cross-over single dose intake of placebo, 2.5 mg bisoprolol or 5 mg bisoprolol. Gaz exchange, heart rate and blood pressure were measured at rest and during cyclo-ergometric CPET.Results: Maximal workload and VO2max were unaffected by the treatment, with maximal respiratory exchange ratio > 1.15 in all tests. A beta-blocker dose-dependent effect reduced resting and maximal blood pressure and heart rate and the chronotropic response to exercise, evaluated by the heart rate/VO2 slope (placebo: 2,9 ± 0,4 beat/ml/kg; 2,5 mg bisoprolol: 2,4 ± 0,5 beat/ml/kg; 5 mg bisoprolol: 2,3 ± 0,4 beat/ml/kg, p<0.001). Ventilation efficiency measured by the VE/VCO2 slope and the ventilatory equivalent for CO2 at the ventilatory threshold were not affected by beta1-receptor blockade. Post-exercise chronotropic recovery measured after 1 min was enhanced under beta1-blocker (placebo: 26 ± 7 bpm; 2,5 mg bisoprolol: 32 ± 6 bpm; 5 mg bisoprolol: 33 ± 6 bpm, p<0.01).Conclusion: The present results suggest that a single dose of bisoprolol does not affect metabolism, respiratory response and exercise capacity. However, beta-adrenergic blockade dose-dependently reduced exercise hemodynamic response by lowering the pressure and chronotropic responses.
Transcriptomic Analysis of Methyl Jasmonate Treatment Reveals Gene Networks Involved in Drought Tolerance at the Early Developmental Stage in Pearl Millet (Pennisetum Glaucum L. Br)
Authors: Ndiaye Adama , Diallo Amadou Oury , Fall Ndèye Coura , Diouf Rose Diambogne , Diouf Diaga , Kane Ndjido Ardo
Published: December 2021

Water deficit stress at the early stage of development is one of the main factors limiting pearl millet production. A practice to cope with would be to apply hormones to stimulate plant growth and development. Exogenous methyl jasmonate (MeJA) can improve drought tolerance by modulating key pathways, therefore, we assumed that can occur in pearl millet during the early stage of development. To decipher the molecular mechanisms controlling these pathways, RNAseq was conducted in two pearl millet genotypes, drought-sensitive SosatC88 and drought-tolerant Souna3, in response to 200 µM of MeJA. Transcriptomic analysis between the MeJA-treated and non-treated plants revealed 3270 differentially expressed genes (DEGs) in SosatC88 and 127 DEGs in Souna3. Gene ontology (GO) classification assigned most regulated DEGs in SosatC88 to heme binding, oxidation-reduction process, response to oxidative stress and membrane, and in Souna3 to terpene synthase activity, lyase activity, magnesium ion binding, and thylakoid. The Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis reveals that DEGs in SosatC88 are related to the oxidation-reduction process, the biosynthesis of other secondary metabolites, the signal transduction, and the metabolism of terpenoids, while in Souna3, DEGs are related to the metabolism of terpenoids and the energy metabolism. Two genes encoding a diterpenoid biosynthesis-related and a Glutathione S transferase T3 were contra-regulated between SosatC88 and Souna3. Additionally, five random genes differentially expressed by RNAseq were validated using qPCR. These insights into the molecular mechanisms of pearl millet genotype tolerance at the early stage of development contribute to the understanding of the role of hormones in adaptation to drought-prone environments.