bluuebunny/crossref_metadata_2025 huggingface dataset:
COMPARISON OF AEROBIC POWER AND CAPACITY BETWEEN ATHLETES FROM DIFFERENT SPORTS
Authors: Souza Fabiano de Barros , Ferreira Ricardo Cesar Alves , Fernandes Wendel Simoes , Ribeiro Wellington , Lazo-Osorio Rodrigo Alexis
Published: December 2018

ABSTRACT Introduction: Ergospirometry is a noninvasive procedure used to assess physical performance or the capacity of an individual, through an analysis of expired gases and respiratory variables. This procedure is crucially important in sports, and makes a significant contribution to the measurement of cardiorespiratory fitness indices, such as maximal oxygen consumption (VO2 max) and the anaerobic threshold (AT). Objective: To assess aerobic capacity and potency in professional and junior soccer players, handball athletes, and women soccer players. Methods: Forty-eight athletes participated voluntarily and were divided into 4 groups. The first group consisted of 12 youth soccer players in the under-20 category, the second group was made up of 12 professional soccer players, the third group was made up of female soccer players, and the fourth group consisted of handball players. Results: We analyzed values such as peak VO2, average speed and heart rate at the anaerobic threshold as well as pulmonary ventilation. We found that the values were always greater for the group formed by professional soccer players, with the exception of mean maximum O2 consumption, in which the difference between this group and that of soccer players in the junior category was not significant. In other physical valences, there was a degree of similarity between the other groups, with special emphasis on pulmonary ventilation, which was significantly lower in the group of female soccer players. Conclusion: The particularities of each sport, such as pitch dimensions, duration, and tactical system, together with the morphology and sex of the athletes, directly influence peak VO2, AT and VE values in athletes who play different sports. Level of Evidence III; Development of diagnostic criteria in consecutive patients (with gold reference standard applied).
COMPARISON OF THE EFFICACY OF LOSARTAN, HYDROCORTISONE AND ACETYLSALICYLIC ACID (ASA) IN PREVENTING THE DEVELOPMENT OF FIBROUS SCAR TISSUE IN SKELETAL MUSCLE
Authors: Melo-Silva Junior Otavio , Nunes Cristiana Buzelin , Corrêa Tchalton Amador , Silva Marilia F. , Freitas Laurice B. , Alberti Luiz Ronaldo
Published: December 2018

ABSTRACT Objective: To analyze fibrous scar tissue inhibition capacity with the use of losartan, hydrocortisone and acetylsalicylic acid. Method: The sample consisted of 120 male heterogeneic Wistar rats with a muscle laceration model. The rats were divided into four groups of 30 animals each: control group, losartan group, ASA group and hydrocortisone group. The animals were anesthetized and a 2.5 cm longitudinal incision was made in the left thoracolumbar paravertebral region. The muscles were subjected to a Grade III lesion caused by applying Kelly hemostatic forceps for 60 seconds, followed by sectioning with scissors. The skin was sutured with 3-0 nylon monofilament thread. The animals were placed in individual cages with plenty of food and water. The losartan group received losartan diluted in water at a dose of 0.1 mg/mL (10 mg/kg/day), the ASA Group received a 3 mg/mL ASA solution (300 mg/kg/day), and the hydrocortisone group received a 0.2 mg/mL hydrocortisone solution (20 mg/kg/day). Results: The control, losartan, hydrocortisone and aspirin groups had a fibrotic area of 0.95 ± 0.35 mm, 0.55 ± 0.34 mm, 0.93 ± 0.33 mm, and 0.66 ± 0.36 mm, respectively. We observed a significantly smaller fibrotic area in the losartan group compared to the control (p=0.01) and hydrocortisone (p=0.01) groups. There were no significant differences among the other groups. Conclusion: The healing of striated skeletal muscle produced less fibrous scar tissue when exposed to losartan in comparison to the control group or the hydrocortisone group. Level of Evidence I; Randomized double-blind placebo-controlled study.
SYMMETRIC-ELECTROMYOGRAPHIC ANALYSIS IN THE EVALUATION OF SCOLIOSIS TREATMENT
Authors: Strasse Wally auf der , Oliveira Karen Regina Galvão de , Beraldo Lucas Menghin , Stadnik Adriana Maria Wan
Published: December 2018

ABSTRACT Introduction: Scoliosis is a three-dimensional deformity of the spine, characterized by a lateral shift that affects body posture. The Pilates Method (PM) promotes alterations in the biomechanics and neuromuscular activation pattern. Objective: The aim of this study was to analyze electromyography (EMG) and symmetrography (SMTG) technologies applied in the evaluation of neuromuscular and postural effects on right convex thoracolumbar scoliosis (RCTS) after applying a PM therapeutic protocol. Methods: This is an exploratory study of 5 male and female adolescents, with an average age of 14.4 years. The subjects underwent postural asymmetry assessments through SMTG and neuromuscular assessment through surface EMG of the trapezius (TRAP), erector spinae (ERE), oblique (OBLI) and rectus abdominis (RA) muscles. The electromyographic signals were processed in the temporal (EMGAmp) and spectral (EMGFmed) domains. The therapeutic protocol consisted of 24 sessions of Pilates floor exercises held twice a week with a duration of 45 minutes. Results: There was an improvement in scoliosis and asymmetric shoulders in one subject (20%) and in three other subjects with hip asymmetry. There was an improvement in one subject (33.33%), as demonstrated by SMTG. EMGAmp measurements demonstrated a significant difference between before and after (p≈0) and among the muscles (p≈0). EMGFmed measurements demonstrated that there was only a difference between before and after (p≈0). It was verified that the most noteworthy muscles in terms of EMGAmp were TRAP and ERE, emphasizing the existence of an increase in the mean EMGAmp for ERE. Muscle behavior for measurements in EMGFmed demonstrated a higher mean increase for RA and OBLI muscles. Conclusion: It is concluded that the EMG and SMTG technologies are important tests for monitoring the progress of scoliosis and in treatment decisions. Level of Evidence III; Diagnostic Studies - Investigating diagnostic tests.
TRACKING OF NUTRITIONAL STATUS BETWEEN CHILDHOOD AND ADOLESCENCE IN SCHOOLCHILDREN
Authors: Prado Taciane Gomes do , Costa Julio Cesar da , Bueno Maria Raquel de Oliveira , Batista Mariana Biagi , Romanzini Marcelo , Ronque Enio Ricardo Vaz
Published: December 2018

ABSTRACT Introduction: In view of the growing prevalence of childhood excess weight and obesity In Brazil In recent decades, it is necessary to observe how this phenomenon occurs in the period of transition to adolescence. Objective: To verify the tracking of excess weight between childhood and adolescence in schoolchildren of both sexes. Methods: The study has a longitudinal design and the data used are part of a prospective study carried out from 2002 to 2005. Participants included 397 schoolchildren of both sexes (211 boys and 186 girls). The nutritional status was determined by the body mass index, and the participants were divided into the following groups: Normal Weight to Normal Weight, Normal Weight to Excess Weight, Excess Weight to Excess Weight, Excess Weight to Normal Weight. The tracking was analyzed using the intraclass correlation coefficient (ICC) and Kappa (k) index. Results: A significant difference (P <0.05) was observed between all variables (age and anthropometric indicators) between 2002 and 2005 for boys and girls. The ICC indicated tracking classified as high (ICC = 0.87) for the BMI values, and the tracking percentage showed that 87% of the subjects remained in the same category of normal weight and excess weight. The values of k = 0.68 show good tracking (P <0.001), indicating a strong maintenance of the subjects in the normal and excess weight categories. Conclusion: The tracking percentage was high, indicating that both boys and girls maintained the classification of excess weight during the period analyzed. Level of Evidence II; Lesser quality prospective study (eg, patients enrolled at different points in their disease or <80% followup).
CARDIAC SYMPATHETIC MODULATION INCREASE AFTER WEIGHT LOSS IN COMBAT SPORTS ATHLETES
Authors: Nascimento-Carvalho Bruno do , Mayta Miguel Angel Condori , Izaias João Eduardo , Doro Marcio Roberto , Scapini Katia , Caperuto Erico , Grilletti Juliana Valente Francica , Sanches Iris Callado
Published: December 2018

ABSTRACT Introduction: Although the rapid weight loss process is undertaken by combat sports athletes very often, the impact of this practice on cardiovascular health is not fully understood. Objective: To verify the effects of the rapid weight loss process undertaken by combat sports athletes on hemodynamic parameters, cardiovascular autonomic modulation and mood state. Methods: Eight male fighters (21.62±1.49 years, 71.25±3.54 kg, 1.74±0.03 cm) were assessed in the city of São Paulo. The subjects had 5.37±0.77 years of practice and were training 5.75±0.45 days per week, for 3.05±0.69 hours per day. The athletes were assessed on 2 occasions: 14 days before and 1 day before official weigh-in. Weight, height and bioimpedance were used for body composition analysis. Mood state was assessed using the Brums Mood Scale. Blood pressure was measured at rest with a digital meter. Cardiovascular autonomic modulation was obtained through an analysis of heart rate variability recorded for 25 minutes at rest. The Student's t-test for dependent samples was used for comparison between time points. Values of p<0.05 were considered significant. Results: No differences in body composition were observed between the time points evaluated. After the weight loss strategy, increases in mood state parameters related to anger, vigor and fatigue categories were observed. Blood pressure did not change between the time points evaluated. However, an increase in heart rate associated with greater sympathetic modulation was observed after the weight loss strategy. There were no differences in autonomic modulation parameters representing parasympathetic activity. Conclusions: The study provided evidence of a higher cardiovascular risk in athletes as a result of this rapid weight loss practice, which is very concerning since combat sports athletes repeat this process several times during their lives. Level of Evidence IV; Study type: Case series.
MANAGERIAL COMPETENCIES AND RESULTS IN RESEARCH GROUPS
Authors: FREITAS PABLO F. P. DE , ODELIUS CATARINA C.
Published: December 2018

ABSTRACT Purpose: The aim of this paper is to identify relationships between “managerial competencies” (MCs) and the resulting extension in Brazilian “research groups” (RGs), as well as differences resulting from sociodemographic/functional characteristics. Originality/value: Just like general organizations, RGs need to invest in aspects that enhance their results, taking more strategic approaches to efficiently gather and manage resources and establish networks and partnerships, features that are influenced by the leader’s competencies, which are not always satisfactorily displayed. In addition, the study is innovative in applying a scale of results in RGs (for the first time), identifying their relationships with MCs. Design/methodology/approach: We employed the Correlation Analysis (Kendall-Tau) and Difference tests between medians (Mann-Whitney and Kruskall-Wallis) from the questionnaires electronically completed by 387 RG leaders who accepted the invitation that was sent to 6,723 researchers. Findings: The study was based on scales with validity evidence, and its findings indicate that to achieve better results, it is not enough for the RGs leaders to control the management of people and research results; they also need to dedicate themselves to gathering resources and people because these MCs are more related to results in RGs. We also identified differences resulting from educational level, gender, scholarship grants, knowledge area, and/or research experience and group relation time.
Cognition, functionality and symptoms in patients under home palliative care
Authors: Scottini Maria Aparecida , Moritz Rachel Duarte , Siqueira José Eduardo de
Published: December 2018

SUMMARY OBJECTIVE: Evaluating the degree of cognition, functionality, presence of symptoms and medications prescribed for patients under palliative home care. METHOD: Descriptive, cross-sectional study where 55 patients under palliative home care were interviewed. Cognition was evaluated using the Mini-Mental state examination (MM), with patients being separated into two groups: with preserved cognitive ability (MM>24), or altered (MM <24). The functionality was verified by the Palliative Performance Scale (PPS) and the patients were divided into two groups: PPS≤50 and PPS≥60. The symptoms presence was evaluated by ESAS (Edmonton Symptom Assessment System) being considered as mild (ESAS 1-3), moderate (ESAS 4-6) or severe (ESAS 7-10) symptoms. Medications prescribed to control the symptoms were registered. Statistical analysis used Student's t test (p <0.05). RESULTS: Most of the 55 patients were women (63.6%), 70.9% of these had MM> 24, 83.6% had PPS <50 and 78.2% presented chronic non-neoplastic degenerative disease. There was a significant relationship between PPS≤50 and MM≤24. Symptoms were present in 98% of patients. Asthenia was more frequently reported and was not treated in 67% of the cases. Severe pain was present in 27.3%: 46% without medication and 13% with medication, if necessary. Most patients with severe dyspnea used oxygen. CONCLUSIONS: Most of the analysed patients had their cognition preserved, presented low functionality and 98% reported the presence of symptoms. Severe pain was present in almost 1/3 of the patients without effective treatment. Re-evaluate palliative home care is suggested to optimize patient's quality of life.
Quality parameters of tomatoes submitted to different doses of gamma radiation
Authors: Loro Ana Carolina , Botteon Victor Wilson , Spoto Marta Helena Fillet
Published: December 2018

Abstract Ionizing radiation can be used for different purposes in the food industry. In this study, the effect of irradiation doses (0, 0.5, 1.0 and 1.5 kGy) on the quality parameters of long life tomatoes (Lycopersicon esculentum Mill.), was evaluated during 4 storage periods (1, 7, 14 and 21 days). The different treatments were evaluated by analysing for colour, pH, total soluble solids (TSS), total titratable acidity (TTA), ratio (TSS/TTA), hardness, total lycopene and ascorbic acid contents, weight loss and maturation stage (O2 /CO2 ratio) for all the storage periods. The tomato samples were irradiated in a Co60 irradiator and maintained at 22 °C ± 1 °C. The quality of the tomato fruits was influenced by the gamma radiation basically by making the fruits softer and not degrading the ascorbic acid and lycopene contents at the doses evaluated. The irradiation process used in the doses evaluated was promising with respect to maintaining the quality parameters of long life tomatoes.
APOPTOSIS, NUTRITION, AND METABOLISM OF TRANSPLANTED INTERVERTEBRAL DISC CELLS
Authors: Giers Morgan B. , Bardonova Liudmila , Eyster Kyle , Byvaltsev Vadim , Preul Mark C.
Published: December 2018

ABSTRACT Introduction: Apoptosis is a contributing factor to degenerating intervertebral disc (IVD). Disc regeneration has been attempted by transplanting cells into the disc, with some gains in disc height achieved in animal models. Here, we study whether the apoptotic microenvironment affects the transplanted disc cells. Methods: Human annulus fibrosus (AF) and nucleus pulposus (NP) cells were grown in media then starved for 5 days in vitro by not changing the media. Three aspects of apoptotic cell influence on the transplanted cells were tested in a total of 32 samples: 1) the effect of apoptotic cytokines in the media, 2) reduced glucose in the media, and 3) apoptotic cell bodies in the flask. The Trypan Blue, AlamarBlue®, and 1,9-Dimethyl-Methylene Blue assays for sulfated glycosaminoglycan (sGAG) content were performed (n=4). Results: There were significant decreases in cell viability between the control, 25% conditioned media (CM) and starved control group. There were no significant differences in cell number, metabolic activity or sGAG production in cells grown in different conditioned media compared to cells grown in complete media. The cells of the control decreased in viability and number over the 5 days without feeding, then improved dramatically when feeding was resumed. Flasks that received transplanted cells in addition to renewed feeding did not recover as much as the cells in the re-fed group. Conclusions: Cytokines from starved cells negatively impact on the viability of healthy cells. Starving cells that receive new sources of nutrition have even higher viability than transplanted cells. This indicates that altering and improving the nutrient supply problem in the IVD could be a valuable option. Level of Evidence III; Case control studyg.
ADOLESCENT IDIOPATHIC SCOLIOSIS AND SIMILAR CONDITIONS: SHORT, APICAL, SINGLE OR MULTIPLE FIXATION
Authors: Garcia Enguer Beraldo , Garcia Liliane Faria , Garcia Jr Enguer Beraldo , Camarinha Juliana Garcia , Camarinha Marcos Felipe , Gonçalves Roberto Garcia , Garcia Eduardo Beraldo , Giesbrecht Saulo Terror , Matos Victor de Oliveira
Published: December 2018

ABSTRACT Objective: To create a new instrumentation principle for the treatment of adolescent idiopathic scoliosis (AIS) and similar conditions. Methods: A new fixation format was created for the treatment of AIS using 3rd generation instrumentation in short, apical and single or multiple fixations. In patients presenting one scoliotic curve, one fixation is performed. In patients with two curves, two fixations are performed, and in those with three curves, three fixations are performed. To evaluate the new method, a retrospective study of 54 patients who had already undergone surgery for AIS and similar conditions using this innovation was conducted. Results: In this series, average corrections of 72% in the proximal curve, of 83% in the thoracic curve, and of 85% in the thoracolumbar curve were verified. Conclusions: It was concluded that the new fixation principle in the treatment of AIS and similar conditions using short, apical and multiple fixations presented excellent correction, better still in the curves that were more distal in relation to the spine. There was a significant statistical difference between the percentages of curvature correction. Level of Evidence III; Retrospective study.
ADOLESCENT IDIOPATHIC SCOLIOSIS AND SIMILAR CONDITIONS: NEW TOOL TO MEASURE THE CORONAL PLANE
Authors: Garcia Enguer Beraldo , Payão Guilherme Brescia , Garcia Liliane Faria , Garcia Jr Enguer Beraldo , Camarinha Marcos Felipe , Gonçalves Roberto Garcia , Camarinha Juliana Garcia , Giesbrech Saulo Terror , Matos Victor de Oliveira
Published: December 2018

ABSTRACT Objective: To create a method to measure the overall coronal plane of the spine, called the sacral clavicular angle (SCA). Methods: A line is drawn at the base of the sacrum; a second central line is drawn perpendicular to the first one in the proximal extension of the spine. A third line is drawn passing through the intersections of the superior points of the clavicles with the two second ribs, forming two angles, the greater of which is measured. Therefore, the degrees exceeding 90° are the SCA values. This tool was tested retrospectively in a study of 46 patients with idiopathic scoliosis who underwent short, apical, single or multiple fixations. Third generation instrumentation was used and the SCA was evaluated in the pre- and postoperative periods, which were compared with another group of 46 patients treated with the traditional technique. Results: Patients submitted to the traditional fixation method presented a median SCA of 3° in the preoperative period, and in the postoperative period, the SCA remained in 3°. Therefore, there was a 0% reduction. Patients submitted to short, apical, single or multiple fixation method presented a median preoperative SCA of 6°, and a postoperative median SCA of 1°, a reduction of approximately 83%. Conclusions: The group treated with short, apical, single or multiple instrumentation presented a reduction in the SCA of approximately 83% in the postoperative period compared to the preoperative period. The difference between preoperative and postoperative values was considered statistically significant. Level of Evidence II; Retrospective study.
EVALUATION OF THE VEPTR SYSTEM IN THE MANAGEMENT OF SPINAL DEFORMITIES BETWEEN 2008 AND 2014 AT THE ROOSEVELT INSTITUTE
Authors: Montero Carlos Segundo , Meneses David , Alvarado Fernando , Godoy Wilmer , Acosta Maria Margarita , Méndez Ricardo José
Published: December 2018

ABSTRACT Objective: Traditional surgical treatments, such as on-site fusion and hemiepiphysiodesis, have not addressed chest deformity in its three dimensions, and are usually insufficient and unpredictable for the management of congenital and neuromuscular scoliosis. The application of the Vertical Expandable Prosthetic Titanium Rib (VEPTR) is a technique developed to treat early-onset progressive scoliosis that elongates the spine and thoracic wall, allowing adequate lung development. Methods: A case series retrospective study was conducted. We included 23 patients, including fifteen females and eight males diagnosed with congenital and neuromuscular scoliosis, who were treated with VEPTR type implants between January 2008 and May 2014. We obtained data about the implant and pre and postoperative radiographic images to assess the magnitude of the curve, and we measured the Cobb angle and length after lengthening, as well as evaluating the complications found. Results: There was an improvement in the postoperative Cobb angle. In patients with congenital scoliosis, deformity correction was 8.6% (p=0.014), and in neuromuscular scoliosis, we observed deformity correction of 19.5% (p=0.009). Likewise, we found gains in thoracic height through the device, which results in an average 10% lengthening of the spine in congenital scoliosis. In this study, we identified complications such as material migrations, rib synostosis, pressure zones, rib fracture, hemothorax, and deep wound infection. Conclusion: The natural history of progressive spinal deformity was improved in most of the minors, through the use of VEPTR. This allows us to continue managing patients in the future, in order to make a deeper assessment of its performance in treatment of early onset scoliosis. Level of Evidence III; Therapeutic studies - Investigating the results of a treatment.
Predictors of Survival in Patients with Advanced Gastrointestinal Malignancies Admitted to the Intensive Care Unit
Authors: Ko Heidi , Yan Melissa , Gupta Rohan , Kebbel Kayla , Maiti Abhishek , Song Juhee , Nates Joseph , Overman Michael J.
Published: December 2018

Background

Patients with cancer have a high use of health care utilization at the end of life, which can frequently involve admissions to the intensive care unit (ICU). We sought to evaluate the predictors for outcome in patients with gastrointestinal (GI) cancer admitted to the ICU for nonsurgical conditions.

Patients and Methods

The primary objective was to determine the predictors of hospital mortality. Secondary objectives included investigating the predictors of ICU mortality and hospital overall survival (OS). All patients with GI cancer admitted to the ICU at the University of Texas MD Anderson Cancer Center between November 2012 and February 2015 were retrospectively analyzed. Cancer characteristics, treatment characteristics, and Sequential Organ Failure Assessment (SOFA) scores were analyzed for their effects on survival.

Results

The characteristics of the 200 patients were as follows: 64.5% male, mean age of 60 years, median SOFA score of 6.7, and tumor types of intestinal (37.5%), hepatobiliary/pancreatic (36%), and gastroesophageal (24%). The hospital mortality was 41%, and overall 6-month mortality was 75%. In multivariate analysis, high admission SOFA score > 5, poor tumor differentiation, and duration of metastatic disease ≤7 months were associated with increased hospital mortality. For OS, high admission SOFA score > 5, poor tumor differentiation, and patients who were not on active chemotherapy because of poor performance had worse outcome. In multivariate analysis, SOFA score remained significant for OS even after excluding patients who died in the ICU.

Conclusion

For patients with metastatic GI cancer admitted to the ICU, SOFA score was predictive for both acute and long-term survival. A patient's chemotherapy treatment status was not predictive for hospital mortality but was for OS. The SOFA score should be utilized in all patients with GI cancer upon ICU admission for prognostication.

Implications for Practice

Patients with cancer have a high use of health care utilization at the end of life, which can frequently involve admissions to the intensive care unit (ICU). Although there have been substantial increases in duration of survival for patients with advanced metastatic cancer, their mortality after an ICU admission remains high. GI malignancy is considered one of the top three lethal cancers estimated in 2017. Survival of critically ill patients with advanced GI cancer should be evaluated to help guide treatment planning.
Axial force–displacement behaviour of a buried pipeline in saturated and unsaturated sand
Authors: Al-Khazaali Mohammed , Vanapalli Sai K.
Published: December 2018

Several pipeline projects have been proposed in the world in recent years owing to the rapid growth of the petroleum industry. Onshore pipeline systems are usually buried above the natural groundwater table, where the soil is typically in an unsaturated condition. Rational interpretation of these pipelines is possible by extending the mechanics of unsaturated soils. In this paper, the axial force exerted by way of the relative movement on a prototype steel pipeline in sand under both saturated and unsaturated conditions is determined from laboratory investigations using specially designed equipment. The test results under the unsaturated condition showed significantly higher axial force on the pipeline compared to the saturated condition, attributable to the contribution from matrix suction. Two analytical models proposed in this study, which take into account the influence of matrix suction and dilation, successfully predicted the peak and residual skin friction along the pipe surface. The framework developed, based on experimental studies and analysis of the results and the proposed models that use saturated shear strength parameters and the soil-water characteristic curve, is promising for generating simple tools for the design of pipeline infrastructure buried in sands to ensure their stability and safety, and at the same time provide economical solutions.
Endogenous Notch Signaling in Adult Kidneys Maintains Segment-Specific Epithelial Cell Types of the Distal Tubules and Collecting Ducts to Ensure Water Homeostasis
Authors: Mukherjee Malini , deRiso Jennifer , Otterpohl Karla , Ratnayake Ishara , Kota Divya , Ahrenkiel Phil , Chandrasekar Indra , Surendran Kameswaran
Published: December 2018

Background

Notch signaling is required during kidney development for nephron formation and principal cell fate selection within the collecting ducts. Whether Notch signaling is required in the adult kidney to maintain epithelial diversity, or whether its loss can trigger principal cell transdifferentiation (which could explain acquired diabetes insipidus in patients receiving lithium) is unclear.

Methods

To investigate whether loss of Notch signaling can trigger principal cells to lose their identity, we genetically inactivatedNotch1andNotch2, inactivated the Notch signaling targetHes1, or induced expression of a Notch signaling inhibitor in all of the nephron segments and collecting ducts in mice after kidney development. We examined renal function and cell type composition of control littermates and mice with conditional Notch signaling inactivation in adult renal epithelia. In addition, we traced the fate of genetically labeled adult kidney collecting duct principal cells afterHes1inactivation or lithium treatment.

Results

Notch signaling was required for maintenance of Aqp2-expressing cells in distal nephron and collecting duct segments in adult kidneys. Fate tracing revealed mature principal cells in the inner stripe of the outer medulla converted to intercalated cells after genetic inactivation ofHes1and, to a lesser extent, lithium treatment.Hes1ensured repression ofFoxi1to prevent the intercalated cell program from turning on in mature Aqp2+cell types.

Conclusions

Notch signalingviaHes1regulates maintenance of mature renal epithelial cell states. Loss of Notch signaling or use of lithium can trigger transdifferentiation of mature principal cells to intercalated cells in adult kidneys.
Development of a new algorithm for treatment of primary angle closure glaucoma
Authors: Kurysheva N. I. , Trubilin V. N. , Kapkova S. G. , Lepeshkina L. V.
Published: December 2018

Purpose – to develop a new algorithm for treatment of primary angle closure glaucoma (PACG) based on laser peripheral iridotomy (PI) and selective laser trabeculoplasty (SLT) and to determine its indications and contraindications. 68 eyes with PACG were observed for 6 years. These patients had undergone PI and then SLT. The control group included 74 POAG eyes of the same age and stage of glaucoma. The effectiveness of SLT was assessed using the Kaplan-Meier survival analysis. The risk factors for SLT failure in the long-term period were studied to determine the indications and contraindications for this treatment algorithm, and the condition of corneal endothelium in dynamics was investigated using confocal microscopy. The hypotensive effect of SLT in PACG was worse than in POAG: 90 and 93% respectively one year after SLT, and 16 and 21% six years after SLT (log rank test, p=0.195). The following factors of SLT failure were common for both forms of glaucoma: IOP >24 mm Hg, corneal thickness ≤540 µm, corneal hysteresis <7 mm Hg and age of patients >68 years. The extension of laser action <1800 and lens thickness >4.8 mm were additional predictors of SLT failure in PACG. In both forms of glaucoma, diabetes mellitus, age of patients and duration of the disease before SLT had a negative effect on the condition of corneal endothelium. The anterior-posterior axis and the presence of pigment deposition on the endothelium were significant in PACG. The proposed algorithm for PACG treatment, including the initial performance of PI and then SLT, is an effective method of treating this form of glaucoma, provided that the opening of the anterior chamber angle is sufficient (at least half) and the lens thickness is no more than 4.8 mm. The initially high IOP, the age of patients over 68 and a thin cornea (<540 μm) worsen the SLT prognosis. Moreover, diabetes mellitus and the presence of pigment deposition on the endothelium along with long-term glaucoma history increase the risk of corneal endothelium damage after SLT.
The normative regulation of dispensary observation of the adult population of Moscow
Authors: Sandakov Ya. P.
Published: December 2018

The review presents an analysis of the normative legal documents regulating the dispensary observation of the adult population of Moscow. There are contradictions in the normative documents that make it difficult to organize a dispensary observation in a medical organization.
SOLIDARIDAD Y PUDOR COMO FILOSOFIA
Authors: Arenillas Carlos Enrique
Published: December 2018

Este trabajo pretende relacionar, en un diálogo posible, a dos autores que se insertan en el movimiento de “curvatura ética” que caracteriza el pensamiento filosófico contemporáneo. Richard Rorty, fiel exponente del nuevo pragmatismo norteamericano, y Pier Aldo Rovatti, pensador italiano “enrolado” en las filas del polémico pensamiento débil. A partir de un diagnóstico similar respecto del debilitamiento del canon filosófico occidental -Rorty dirá que simplemente este ha dejado de funcionar, mientras que Rovatti sostendrá toda una intencionalidad filosófica tendiente a demostrar su derrumbe- ambos autores con estilos y propuestas distintas, coinciden en la entonación ética de sus ideas en las que se elogia la solidaridad (Rorty) y el pudor (Rovatti) como formas que el pensamiento debe asumir.
El operativo retorno de Alberdi y sus amigos durante la presidencia de Sarmiento (1868-1874)
Authors: Mele Marcos
Published: December 2018

ResumenUn problema político acuciante recorre la trayectoria de Alberdi al interior del círculo dirigente durante las décadas de 1860 y 1870. En 1868 Sarmiento es electo presidente e impone la imagen de Alberdi como un traidor a la patria por su legitimación del gobierno López durante la Guerra del Paraguay (1865-1870). Para derribar esta imputación y posibilitar su regreso al país, Alberdi, con la colaboración de sus partidarios en el Río de la Plata, inicia una operación política denominada por Herrero como el operativo retorno. Ésta alcanzará el éxito con el regreso de Alberdi en 1878, siendo electo diputado nacional; y fundamentalmente durante la presidencia de Roca, quien posiciona a Alberdi como el pensador de la nación.En este artículo se indagará una etapa germinal del operativo retorno, en el marco de la presidencia de Sarmiento, donde el discurso político de Alberdi circula con mayor resistencia.
La fobia al Estado como remedio espiritual. Incisiones foucaultianas sobre el neoliberalismo
Authors: Méndez Pablo Martín
Published: December 2018

Resumen La obra de Michel Foucault contiene un sinnúmero de pasajes sumamente incisivos y polémicos; algunos de ellos resultan bastante conocidos, mientras que otros han sido a pesar de todo poco frecuentados. Se trata principalmente de las investigaciones sobre “la fobia al Estado”; o como diría Foucault, se trata de buscar la “procedencia” de un concepto, e incluso de un modo de juzgar al mundo, que resuena muchas veces en ciertas posturas críticas y hasta contestatarias. Habría sin embargo una cuestión inquietante, y es que la procedencia de aquella fobia conduce justamente hacia el discurso neoliberal de mediados del siglo XX. En efecto, de allí provienen las actitudes y las posturas que presentan al Estado como un monstruo omnipotente y aglutinador, un monstruo cuya fuerza avasalladora cubriría gradualmente la totalidad de la sociedad civil. Pero también de allí, del discurso neoliberal, proviene la necesidad de desplegar una política gubernamental completamente específica: esa política deberá garantizar la competencia de mercado; o más precisamente, deberá generar las condiciones sociales y espirituales que requeriría la competencia misma. Pues bien, el siguiente artículo sostendrá que la fobia al Estado encaja perfectamente en tales condiciones, tan perfectamente que de hecho tiende a ser incitada por las políticas gubernamentales del neoliberalismo.
Características sociodemográficas, económicas, laborales, y académicas de estudiantes de Maestría y su relación con el armado y presentación de tesis
Authors: Arakaki Jorge , Spinelli Hugo
Published: December 2018

Este trabajo investiga el impacto de algunos factores en el armado y la presentación exitosa de las tesis de maestría. Se realizó una encuesta, con estudiantes que pasaron por la Maestría en Epidemiología, Gestión y Políticas de Salud o la Maestría en Metodología de la Investigación Científica, ambas de la Universidad Nacional de Lanús, entre los años 1998 y 2013. Se enviaron 749 formularios y se obtuvieron 283 respuestas, 65 (22,9%) fueron de graduados. La encuesta, de carácter individual y autoadministrada, se operacionalizó mediante un formulario de 40 preguntas que indagan sobre las dimensiones: sociodemográfica, económica, laboral y académica. Se encontraron tres variables asociadas en forma estadísticamente significativa con la graduación: el nivel de instrucción bajo en las madres, el no reconocimiento de horas para cursar y el reconocimiento económico del título. Para conocer el estado del problema en el exterior se entrevistó a docentes investigadores que se desempeñan en México, Brasil y en Estados Unidos.Se concluye que la explicación del problema (baja tasa de graduación) involucra no solo a los aspectos propios de los estudiantes, sino también a la estructura y la calidad académica, y a las políticas económicas, laborales y educativas.
Del estatus epistemológico de la epistemología
Authors: Mombrú Ruggiero Andrés
Published: December 2018

La epistemología ha sido tenida como la ciencia de la ciencia sin más. En esta idea, inocua a primera vista, se esconde una intención de colonizar la disciplina con una impronta que pretende significarla como una actividad que tiene por objeto establecer los parámetros de legitimidad de la investigación científica. Sin embargo, entendemos que la epistemología es un campo de luchas del que participan otras formas de entender a esta disciplina y en consecuencias no se encuentra sujeta a una única definición. Tal problema nos lleva a reflexionar sobre el estatus epistemológico de la epistemología y sus características particulares que la diferencian pero al mismo tiempo la relacionan de manera diversa con la filosofía, la filosofía de la ciencia, la metafísica y la ética.
Sujeto y verdad: Una Convergencia en Foucault y Lacan
Authors: Alazraqui Hugo
Published: December 2018

En el presente trabajo se intentará fundamentalmente una articulación entre los textos: Las redes del poder 2, La hermenéutica del sujeto3 (clase del 6 de enero) de Michel Foucault y el texto de Jacques Lacan “Subversión del sujeto y dialéctica del deseo en el inconsciente freudiano
Philip Kitcher , Avance de la Ciencia. Ciencia sin ley, Objetividad sin Ilusiones. México, UNAM, 2001
Authors: Paravano Gabriel , Muñoz Diego
Published: December 2018

¿Cómo hacen realmente ciencia los científicos? El filósofo ingles Philip Kitcher (1947) se ocupa de pensar el quehacer científico analizando, a lo largo de 8 capítulos y un Post Scriptum, cómo se constituyen los procesos de formación de investigadores, las relaciones entre autoridades y alumnos, el modelo de mente que se conjetura comoparte del sistema de pensamiento del razonamiento científico, los criterios ontológicos y epistémicos que entran en juego en las variaciones cognitivas de las micro-comunidades científicas en breves periodos de tiempo (6 meses aproximadamente), la influencia de las amistades y las conversaciones de pasillo para delinear los proyectos de investigación,como también la relación implícita –y necesaria– entre la financiación de las instituciones científicas hacia ciertos proyectos de investigación y la propuesta de cuál es la ciencia que un sector y/o región debería desarrollar.
Trastornos de la Conducta Alimentaria y Estilos Parentales
Authors: Losada Analía Verónica
Published: December 2018

Los trastornos alimentarios son patologías altamente frecuentes en mujeres jóvenes, y según la literatura el funcionamiento familiar juega un rol importante tanto en su desarrollo como en su curso y evolución. La presente investigación tuvo como objetivo principal caracterizar la percepción que tienen las pacientes con un Trastorno de la Conducta Alimentaria del Estilo de Crianza prevalente en su entorno familiar, e investigar cómo podría asociarse esto con el desarrollo de la patología. La muestra estuvo compuesta por 16 pacientes del Instituto Argentino de Trastornos de Alimentación, cuyas edades oscilaban entre 12 y 21 años, 4 de ellas padecían Anorexia, 8 Bulimia y los 4 restantes Trastorno de la Conducta Alimentaria No Especificado (TANES). Se aplicó una adaptación de la Escala Argentina de Percepción de la relación con los padres de Richaud de Minzi (2002), para evaluar el tipo de estilo de crianza prevalente en cada cuadro. Para complementar estos resultados, se hizo una revisión de las historias clínicas de las pacientes y se administraron a su vez una serie de entrevistas a los profesionales que atendían a estas pacientes, conformado por psicólogo, nutricionista, y médico clínico. Los principales hallazgos dan cuenta de que existe un Estilo de Crianza preponderante en cada Trastorno Alimentario, es decir en la Anorexia reina un Estilo Permisivo, en la Bulimia un Estilo Autoritario y en los TANES un Estilo Indiferente. Eating disorders are highly frequent pathologies in young women, andaccording to the literature family functioning plays an important role both in its development and in its course and evolution. The main objective of the present investigation was to characterize the perception of patients with Eating Habits Disorder of the Critical Style prevalent in their family environment, and to investigate how this could be associated with the development of pathology. The sample consisted of 16 patients from the Argentine Institute of Eating Disorders, whose ages ranged from 12 to 21 years, 4 of them suffering from Anorexia, 8 Bulimia and the remaining 4 Disorders of Unspecified Food Behavior (TANES). An adaptation of the Richaud de Minzi (2002) Argentine Perception Scale was applied to evaluate the type of parenting style prevalent in each table. To complement these results, a review of the patients’ clinical histories was carried out and a series of interviews were administered to the professionals who attended these patients, consisting of psychologist, nutritionist, and clinical doctor.The main findings are that there is a predominant Fostering Style in eachEating Disorder, that is, in Anorexia, a Permissive Style reigns, in Bulimiaan Authoritarian Style, and in TANES an Indifferent Style.
Enseñanza de metodologías de la investigación científica en la Universidad Nacional de Rosario (UNR) Una mirada sobre los planes de estudios El caso de Psicología
Authors: Espinosa Andrea
Published: December 2018

En este escrito se abordan algunas de las características sobresalientes respecto de la enseñanza de Metodología de la Investigación Científica encarreras de grado universitario en el contexto de la UNR. Una mirada inicial sobre la narrativa de los Planes de Estudios se realiza tomando el caso de Psicología como modelo dentro de las Ciencias Sociales. A partir del análisis de cuatro dimensiones básicas observadas en los documentos, así como en lo narrado por un docente, puede observarse la complejidad del entretejido de factores que influyen sobre la forma de pensar la enseñanza de contenidos metodológicos en este contexto.Palabras claves: Enseñanza – Metodología – Universidad.This paper deals with some of the major characteristics of the teaching ofScientific Research Methodology in university degree careers at UNR. Aninitial look at the narrative of the Curriculum is done, taking the one from Psychology as a model from Social Sciences. From the analysis of four basic dimensions observed in the documents and the words from a teacher it can be understand the complexity of the complexity of the interweaving of factors that influence the way of thinking the teaching of methodological contents in this context.
Villa Muñecas: El deterioro laboral y social que generó el cierre de los ingenios y la partida del tren
Authors: Osatinsky Ariel , Del Castillo Alejandra
Published: December 2018

Este artículo describe las características que asume la pobreza en Villa Muñecas, un barrio de Gran San Miguel de Tucumán, analizando los procesos que determinaron el pasaje de un barrio obrero a un área de privación.Los interrogantes que guían su desarrollo son ¿Cómo incidieron las transformaciones económicas, sociales y territoriales en el devenir histórico de Villa Muñecas? ¿Cuáles son las manifestaciones actuales de la pobreza en esta área? ¿Qué cambios se observan en las configuraciones de la pobreza?Se realiza un estudio de caso centrado en dimensiones vinculadas al trabajo y al hábitat teniendo en cuenta el devenir histórico.
Contra la genuflexión y el cipayismo académico en materia de ciencia, investigación y publicación Un análisis de la hora
Authors: Mombrú Ruggiero Andrés
Published: December 2018

En momentos en que en nuestro país el sistema de ciencia y técnica está siendo desmembrado –como Tupac Amaruc en la Plaza de Armas de Cuzco–, resulta difícil realizar cualquier tipo de evaluación o diagnóstico sobre las virtudes y defectos del estado de la investigación en Argentina. ¿Para qué futuro educamos?, se preguntaba hace algunas décadas la pedagoga uruguaya Reina Reyes. Parafraseando esa interrogante podríamos preguntarnos, ¿para qué futuro investigamos?, ¿para qué futuro publicamos?, ¿para qué proyectos individuales y colectivos trabajamos? Difícilmente estas preguntas encuentren una respuesta que nos rescate a nosotros mismos, si no somos capaces de “salir de nuestra autoculpable minoría de edad”, pensando por cuenta propia, y  fundamentalmente mientras no abandonemos el colonialismo cultural en el que nos vemos sometidos cuando agachamos la cabeza y aceptamos de modo incondicional los parámetros que evalúan las condiciones de investigación y publicación impuestos por los mercaderes de la ciencia. Construyamos nuestras propias redes y reflexionemos juntos sobre los temas de nuestro común interés y determinemos un modo de evaluarnos que al criterio de “impacto” contraponga la socialización del conocimiento.
An Investigation of the Mechanism Magnetite Precipitation Using Ammonium Carbonate
Authors: Frolova L.A. , Derimova A.V. , Butyrina T.E. , Savchenko M.O.
Published: December 2018

The purpose of this study is to determine the phase composition of iron oxide compounds formed during precipitation by ammonium carbonate hydrolysis products, to establish the magnetite formation regions and the kinetic characteristics of the reaction formation Fe3O4. Characterization by X-ray diffraction (XRD) indicated that magnetite is formed in a solution of ferrous sulphate during the hydrolysis of ammonium carbonate. It has a homogeneous phase composition and a cubic crystal structure. Phase diagrams of the formation of the crystalline phase of magnetite, goethite and ferric hydroxide have been determined. It has been established that magnetite with a spinel structure is formed under controlled slow precipitation from ferrous sulphate with an ammonium carbonate solution. The calculation of the kinetic characteristics of the reactions of solid phase precipitation (a rate constant at different initial concentrations of ferrous sulphate, the order of the reaction) has shown that the process proceeds in two stages with the formation of an intermediate compound and its further oxidation. Moreover, the rate constant of oxidation is 0.654 L/min mol, and the rate constant of the first reaction is much higher – 1.645 L/min mol.
Geliat Tafsir ‘Ilmi di Indonesia dari Tafsir Al-Nur hingga Tafsir Salman
Authors: Muchlisin Annas Rolli , Nisa Khairun
Published: December 2018

This article discusses a long journey of ‘ilmi interpretation in Indonesia since the era of 1960s until now. The author concerns at how the interpretation with this style is transformed along with the rapid development of science and technology. Although the debate over the status of ‘ilmi> interpretation is never end, at least the scholars are divided into three groups: the advocates, the rejectionists, and the moderates, but this interpretation continues to emerge in different parts of Muslim countries, including Indonesia. Since the 1960s, the ‘ilmi interpretation embryo had appeared in several works of Nusantara’s Mufassir. This embryo then developed in the era of the 1990s with the outbreak of books that explained the relation of al-Qur’an and science. This stage was growing again in the year 2010s in the form of intact interpretation work. This study shows that the dynamics of ‘ilmi interpretation journey in Indonesia are very dynamic.