bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinerja Lingkungan, Biaya Lingkungan dan Kinerja Keuangan
Authors: Rahayudi Adinda Maharani Putri , Apriwandi Apriwandi
Published: January 2023

The purpose of this study is to ecamine the effect of environmental costs on financial performance mediated by environmental performance listed on the IDX 2019-2021. Financial performance in this study is measured by Return on Assets (ROA). The population in this study are manufacturing companies listed on the IDX during the 2019-2021 period. The sampling technique used purposive sampling, which consisted of 41 companies. The results of this study indicate that environmental costs have no effect on environmental performance, environmental costs have no effect on financial performance, environmental performance have a positive effect on financial performance, and environmental performance is unable to mediate the effect of environmental costs on financial performance.
Peran CSR Memoderasi Hubungan Intensitas Modal, Kepemilikan Institusional, dan Ukuran Perusahaan dengan Penghindaran Pajak
Authors: Dewi Mega Arisia , Edriani Devi , Bangun Swasta , Hasibuan Posman WH
Published: January 2023

This study is to examine tax avoidance through CSR as a moderating variable: capital intensity, institutional ownership, and firm size. Capital Intensity, Institutional Ownership, and Firm Size are used as independent variables and Tax Avoidance is used as the dependent variable. And CSR as a moderating variable. This research was conducted on manufacturing companies listed on the Indonesia Stock Exchange (IDX) in 2017-2021. The method of determining the sample in this study was using purposive sampling method so that from 195 populations, a sample of 44 companies was obtained. The research data were analyzed using panel data analysis techniques using Eviews9. The result of the research shows that Capital Intensity has a partial effect on Tax Avoidance, while Institutional Ownership has no partial significant effect on Tax Avoidance and Company Size also has no significant effect on Tax Avoidance. Capital Intensity and Institutional Ownership moderated by CSR have an effect on Tax Avoidance. While Company Size moderated by CSR has no effect on Tax Avoidance. It is hoped that this research can help manufacturers listed on the Indonesia Stock Exchange to find out Tax Avoidance by considering the factors that have a significant effect on tax avoidance such as the effect of capital intensity, institutional ownership and company size as well as CSR as a moderating variable.
Pengaruh Pengetahuan Wajib Pajak dan Sosialisasi Pajak terhadap Kepatuhan Wajib Pajak dengan Kesadaran Wajib Pajak sebagai Variabel Intervening
Authors: Zaikin Muhammad , Pagalung Gagaring , Rasyid Syarifuddin
Published: January 2023

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh pengetahuan wajib pajak dan sosialisasi pajak terhadap kepatuhan wajib pajak dengan kesadaran wajib pajak sebagai variabel intervening. Objek penelitian adalah Wajib Pajak Orang Pribadi yang terdaftar di KPP Pratama Kendari. Penentuan sampel memakai Teknik accidental sampling, yang dapat didefinisikan sebagai teknik penentuan sampel berdasarkan kebetulan. Jumlah populasi dalam penelitian ini yaitu 267.023 wajib pajak. Dengan menggunakan rumus slovin, diperoleh 100 orang responden. Pengambilan data menggunakan kuesioner dengan analisis data menggunakan Partial Least Sguare (PLS), analisis statistik deskriptif, uji validitas, uji reliabilitas, dan untuk menguji hipotesis melalui analisis koefisien regresi dan statistik t. Hasil penelitian menunjukkan bahwa: pertama, pengetahuan wajib pajak berpengaruh positif dan signifikan terhadap kepatuhan wajib pajak. Kedua, sosialisasi pajak berpengaruh positif dan signifikan terhadap kepatuhan wajib pajak. Ketiga, kesadaran wajib pajak berpengaruh positif dan signifikan terhadap kepatuhan wajib pajak. Keempat, pengetahuan wajib pajak berpengaruh positif dan signifikan terhadap kesadaran wajib pajak. Kelima, sosialisasi pajak berpengaruh positif dan signifikan terhadap kesadaran wajib pajak. Keenam, kesadaran wajib pajak memediasi pengaruh pengetahuan wajib pajak terhadap kepatuhan wajib pajak. Ketujuh, kesadaran wajib pajak memediasi pengaruh sosialisasi pajak terhadap kepatuhan wajib pajak.
Pengaruh Gender Terhadap Kualitas Laporan Keuangan Pada Perusahaan Manufaktur Terdaftar Di Bursa Efek Indonesia
Authors: Anizar Sriyunia , Anastasia Maria , Rahman Adi , Yanti Jaya Bahwi
Published: January 2023

The purpose of this study is to examine the effect of gender equality on the quality of financial statements as a proxy for the auditor's opinion. This research is a quantitative associative study with units of analysis of audited financial statements and independent auditor reports issued by KAP. This study used secondary data, data analysis techniques used logistic regression with SPPS version 26 software. The sample selection used a purposive sampling method. The results of the study show that the board of committees and the board of directors have no influence on the quality of financial reports. The gender equality variable represented by the audit committee board is proven to have no effect on the quality of the financial statements as a proxy for the auditor's opinion. This means that the availability or unavailability of women on the audit committee board does not affect the opinion that will be issued by the auditor. The gender equality variable represented by the board of directors has proven to have no effect on the quality of the financial statements as proxied by the auditor's opinion. This means that the availability or unavailability of women on the board of directors does not affect the opinion that will be issued by the auditor.
Strategi Implementasi Sistem Manajemen Anti Penyuapan dalam Mewujudkan Good Governance
Authors: Taufiq Mohamad , Violita Evony Silvino
Published: January 2023

This research aims to evaluate the organizational readiness of Training Center Z if it will implement SNI ISO 37001: 2016 Anti-Bribery Management System to realize good governance. The implementation of the anti-bribery management system is needed because the Z Training Center as a public service work unit cannot be separated from the potential risk of bribery. The anti-bribery management system as one of the instruments of governance is expected to be a system that can prevent, detect, report, and handle potential acts of bribery and realize good governance within the Z Training Center. This research uses the Gap Analysis method in measuring the readiness of the implementation of the anti-bribery management system and the Strengths Weaknesses Opportunities Threats analysis method combined with the Analytical Hierarchy Process to produce a strategy for implementing an anti-bribery management system in the short term, medium term, and long term in order to realize good governance in the Z Training Center environment. The results showed that Training Center Z was not ready to implement an anti-bribery management system because Training Center Z employees had never received training on anti-bribery management systems and there was no risk assessment of bribery, so an implementation strategy was needed to implement and realize good governance. These strategies include conducting anti-bribery management system training to all employees, socializing anti-gratuities, assessing bribery risks, budgeting activities, and making policies/guidelines for implementing anti-bribery management systems. The results of this study are expected to be knowledge for the leadership of the Z Training Center on how readiness and guidance in developing strategies for implementing an anti-bribery management system in order to realize good governance.
Urgensi Nilai Perusahaan: Antara Relevansi Earning Per Share, Struktur Modal dan Kebijakan Dividen
Authors: Effendi Bahtiar
Published: January 2023

Firm value is one of the measurements used to gain the trust of investors and creditors. A high company value will make investors believe in investing their capital or investing in a company, because a high company value indicates high shareholder prosperity indirectly. This study aims to determine whether there is influence between earnings per share (EPS), capital structure, and dividend policy on firm value. The companies studied are consumer goods companies listed on the Indonesia Stock Exchange in 2018 – 2021. This research is a quantitative study. The population in this study is the company's consumption of goods and the sample method used is purposive sampling. The data analysis technique used is descriptive statistics, multiple linear regression analysis, coefficient of determination (R2), partial test (t test) and simultaneous test using SPSS version 26.00. The results of the study found that earnings per share and dividend policy have a significant effect on firm value, capital structure has no effect on firm value and simultaneously earnings per share, dividend policy and capital structure have a significant effect on firm value.
Efektivitas Inkubator bisnis terhadap pendampingan komunitas usaha
Authors: Firdaus Firdaus , Hudaya Chairul , Salam Abdul
Published: January 2023

The existence of the STIE BIMA business incubator as a facilitation facility in accelerating entrepreneurial growth is expected to be the answer to some of the problems of business partners who will be incubated (tenants). This study aims to determine the effect of Business Incubator Effectiveness on Business Community Assistance with a case study at the Bima University of Economics. This research uses a quantitative descriptive approach. The research population is the entire business community assisted by Inbis STIE Bima totaling 165 groups. The research sample was determined by Stratified random sampling method, amounting to 100 respondents. The results of the study show that there is a significant effect of the effectiveness of the business incubator (Variable X) on assisting the business community (Variable Y) by the STIE Bima business incubator. So that it can be concluded that the effectiveness of the STIE Bima business incubator organization regarding business community assistance also shows evidence that there is significance. This research suggests that there is a need to increase the resource capabilities of the STIE Bima business incubator management team and collaboration with various policy-making stakeholders to support business community assistance.
Fayda ve Zarar Unsurlarının Varlığının İntihal Yargılamasına Tesiri
Authors: ARSLANTÜRK Yalçın , SOYAL Refika
Published: January 2023

Bilimsel çalışmaların özgünlüğü temel olarak etik kurallara riayetle sağlanabilmektedir. Bu kuralların başında ise intihal yasağı gelir. İntihal yasağının herhangi bir fikrin, ortaya atıldığı ilk eser ile irtibatının korunmasına yönelik mahiyette olduğu söylenebilir. Doktrinde genel kabul gören görüşe göre yazarın bilerek ya da bilmeyerek başkalarına ya da kendisine ait mevcut eserlerden aşırma yaparak oluşturduğu eserin, intihalin tespitiyle birlikte bilimsel bir geçerlili- ğinin bulunmadığı ortaya çıkmaktadır. Konuya ilişkin ulusal mevzuatta ise yalnızca başkalarına ait eserlerden yapılan aşırmalar intihal olarak kabul edilmektedir. Esere ilişkin bilimsel alandaki yaptırımın yanında intihalin, fail açısından birtakım hukuki sonuçları da bulunmaktadır. Bu çerçevede kanun koyucu tarafından idari ve cezai yargılama öngörülmüştür. Genellikle göz ardı edilmesi nedeniyle intihale ilişkin Fikir ve Sanat Eserleri Kanunu’ndaki cezai hüküm ile Türk Ceza Kanunu’nun ilgili maddelerinin karşılaştırmalı olarak değerlendirilmesi, makalenin odak noktasını oluşturmaktadır. Çalışmada özellikle intihal barındıran eser üzerinden sağlanan fayda ile uğranan zararın, söz konusu iki kanuna başvuru noktasındaki önemi analiz edilmiştir. Zira akademik unvana ve dolayısıyla bu unvan karşılığındaki kadro ve ücretlere hak kazanılmasında dikkate alınmaları nedeniyle bilimsel çalışmalarda yapılan intihâller neticesinde haksız menfaat ve -başta kamu zararı olmak üzere- zarar oluşmaktadır. Ayrıca Türk Ceza Kanunu kapsamındaki dolandırıcılık ile nitelikli dolandırıcılık arasındaki ayrım gözetilerek intihal eylemiyle bu iki suç- tan hangisinin unsurlarının gerçekleştiği değerlendirilmiştir. Bu değerlendirmelerde yazarın kendi eserlerinden yapmış olduğu aşırmaların durumu da analiz edilmiştir. Çalışmada son olarak intihal eylemine iştirak hâlinde uygulanabilecek cezai müeyyideler de değerlendirme konusu yapılmıştır.
Buscando a identificação de causas sobre a qualidade discutível da educação brasileira
Authors: Pereira Antonio Batista , Pereira Betina Kappel
Published: January 2023

A partir das críticas feitas a qualidade da educação brasileira foi elaborado este trabalho, o qual tem como objetivo principal buscar possíveis causas que estão contribuindo com a baixa qualidade da educação brasileira. A investigação foi baseada em três perguntas: a. Como a aprendizagem e o ensino são tratados no ambiente escolar por professores e alunos? b. Como a aprendizagem e o ensino são tratados pelos pesquisadores? c. Como a aprendizagem e o ensino são tratados pelos gestores da educação? Para responder a primeira foram consultados duzentos e quarenta e dois alunos e trinta e seis professores, sobre qual palavra foi mais ouvida “ensino” ou “aprendizagem”, as respostas indicaram ensino em duzentos e setenta e seis e aprendizagem apenas duas. Para responder a segunda foram utilizadas palavras chaves com ensino e aprendizagem e com estas buscou-se no Google trabalhos publicados. Foram identificados cento e oitenta e cinco dos quais, 80 % pesquisaram ensino, 12,5 % pesquisando ensino e aprendizagem e apenas 7,7 % da amostra trata de aprendizagem. Nas leis que regem a educação brasileira, na LDB a palavra ensino aparece cento e noventa vezes e a palavra aprendizagem sete vezes ensino e aprendizagem apenas uma. Na BNCC a palavra ensino aparece quinhentas e quarenta e duas vezes, a palavra aprendizagem cento e trinta e quatro e a palavras ensino-aprendizagem apenas onze vezes. Isto demonstra que além da legislação estar focada principalmente no ensino o problema é agravado pelo fato de ensino e aprendizagem estarem aparentemente desvinculados.
Desenvolvimento de um e-book para auxiliar o ensino da antibioticoterapia no curso de Medicina
Authors: Lima Luan Victor Almeida , Melo Iury Magalhães Dutra , Matos Filho Jesamar Correia , Albano Maria Clara de Freitas , Santos Ana Beatriz Sousa , Lima Amanda Almeida , Bandeira Tereza de Jesus Pinheiro Gomes
Published: January 2023

O ensino médico passou por uma série de transformações ao longo das últimas décadas. As mudanças curriculares, cada vez mais, requerem profissionais capacitados na integração e manuseio dos novos recursos. Estas alterações no modo de educar, ensinar e instruir são necessárias para formação completa dos estudantes de medicina, visto que a tecnologia está promovendo grandes avanços na área médica. Hoje, um dos maiores desafios do curso de Medicina, que demanda atenção dos docentes, é a preparação dos alunos para uma prescrição consciente, principalmente com relação aos antimicrobianos, visto que erros podem levar a resistência antimicrobiana e até mesmo a prejuízos para os pacientes. Diante disso, o presente estudo tem como objetivo desenvolver um e-book de fácil manuseio e de leitura acessível para auxiliar o ensino da antibioticoterapia. Finalizada a elaboração do material, este foi disponibilizado para um grupo de alunos de uma mesma turma do curso de medicina. Posteriormente, uma prova foi aplicada a todos os alunos desta mesma turma. O número total de participantes do estudo foi de 102 alunos, dos quais 83,33% (N=85) não tiveram acesso ao e-book. A taxa de acertos das questões no grupo de alunos que não tiveram acesso ao e-book foi 52,07% e no grupo que teve acesso ao E-book foi 89,80%, diferença de 37,73%, variando de 1,18% a 67,06%. Portanto, conclui-se que é essencial a introdução das metodologias digitais como alternativas para auxiliar o estudo dos alunos.
Cepas atípicas de Toxoplasma gondii e seu impacto no desenvolvimento da toxoplasmose
Authors: Vieira Giulia Caroline Dantas , Duarte Érica dos Santos Martins
Published: January 2023

O presente artigo tem como objetivo por esclarecer a estrutura populacional de cepas de T. gondii e seus padrões de virulência, a caracterização das cepas atípicas, bem como abordar sobre as alterações e complicações relacionadas às cepas de T. gondii. Foram selecionadas 59 referências nas línguas portuguesa, inglesa e espanhola datadas entre os anos de 1992 e 2021 a partir das bases de pesquisa PubMed, SciELO, Elsevier, ScienceDirect e Google Acadêmico, utilizando-se das palavras-chave Toxoplasma gondii, Genotipagem e Toxoplasmose de forma única ou combinada. O T. gondii possui um ciclo de vida com reprodução sexuada bem definido que ocorre na natureza mais raramente em países da América do Norte e Europa. Baseando-se em cepas isoladas nessas regiões, a população de T. gondii foi diferenciada em três linhagens clonais, implicando em uma baixa diversidade genética. Apesar do padrão genotípico observado, a América do Sul, especialmente o Brasil, tem apresentado a existência de uma maior variabilidade genética, caracterizando cepas de genótipo não clonal denominadas atípicas. A existência dessas cepas pode estar associada a ampla distribuição geográfica, fauna e recombinação de cepas clonais através do ciclo sexuado nos felinos. Mesmo que ainda não haja uma correlação bem definida entre virulência dos isolados com a sintomatologia apresentada pelos pacientes com toxoplasmose, sabe-se que estes apresentam uma maior gravidade da doença quando comparados as infecções nos países da Europa e América do Norte, apontando uma possível relação entre o polimorfismo genético das cepas de T. gondii com a patogenia da toxoplasmose.
Exploring Ways of Conducting Cultural Heritage Education Programs Using 3D Puzzles
Authors:   The Korean Society of Culture and Convergence, Cho Daeyoun , Woo Jinyoung , Park Chanho
Published: January 2023

Recently, as the level of public awareness about cultural heritage has improved, the need for more effective cultural heritage education programs is increasing. In this study, we analyzed all cases of cultural heritage 3D puzzle experiential education, which has recently been in the limelight in the face of the COVID-19 situation. Based on the results, a new way of undertaking cultural heritage education programs was attempted by operating a 3D puzzle experience and education program at Jeongeup Museong Seowon for in Jeongeup City elementary school students. The educational effects of the 3D puzzle experience are (1) a sense of achievement felt by participating students, (2) increased pride in the local cultural heritage felt by family members and the local community by owning the finished product. In addition, appropriate lectures and experiential education by professional instructors was appropriately arranged in consideration of the level of the students, and it was confirmed that the effect of the class is doubled when the students adopt the method of directly exploring the cultural heritage or watching related videos.
A Study on the Essence of K-Pop Globalization : About the Popularity of the Marketing Side
Authors:   The Korean Society of Culture and Convergence, Kim Hyuntai
Published: January 2023

The purpose of this paper is that existing studies tend to analyze K-pop itself on the nature of the success of K-pop globalization, but this paper aims to discuss the acquisition of popularity macroscopically through a broad and universal analysis of the properties of the public. For this study, the characteristics of existing K-pop research were examined and the properties of popular art were discussed. Finally, the results according to how the popular art providers set their marketing targets were explained with an example. It is expected that this article will be able to contribute to research that secures the popularity of various cultural products as well as existing K-contents through consideration of the essence of K-pop success.
The Postcolonial Feminism in Choi Seungja's Poem: Focusing on Choi Seungja's Poetry Book in the 1980s
Authors:   The Korean Society of Culture and Convergence, Lim Hyeongjin
Published: January 2023

Choi Seung-ja confesses the absence of an existential self in a poetry book in the 1980s and declares denial of the oppressive world. Decolonist feminism combined a decolonist view of escaping imperial colonialism with a feminist view of breaking away from patriarchal oppression structures. In her poems, Choi Seung-ja criticizes the structure of imperialist oppression, resists colonial patriarchal discrimination, and shows this decolonist feminist perspective. Gayatri Chakravorty Spivak, a representative scholar of decolonist feminism, suggests a way to eliminate racism, sexism, bourgeois individualist ideology, and the injustice of neo-colonialism by contacting and confronting peripheral and Western-centered cultures. In this paper, I would like to analyze Choi Seung-ja's poem, which is the voice of the sub-subject from the perspective of the Postcolonial Feminism.
Structural Relationships among Digital Competence, Self-Efficacy and Income of Middle-aged and Elderly
Authors:   The Korean Society of Culture and Convergence, Kim Soojin , Shin Hayoung
Published: January 2023

The purpose of this study is to analyze the structural relationship between digital competence and self-efficacy and income of middle-aged and older adults. For this, a structural equation model was used with digital competency (PC/mobile) as the input variable, household income as the dependent variable, and self-efficacy as the parameter. The data used for the analysis are from the survey result of “2018 Digital Information Divide Actual Condition Survey” by the National Information Society Angency. As a result of the study, PC, mobile and the two combined digital competency all had a positive effect on increasing the income, and digital competency had a positive effect on increasing self-efficacy in digital use.
A Study on Spatial Contents for Formation of Placeness in Water-Friendly Urban Park : Focusing on 3.15 Ocean Nuri Park
Authors:   The Korean Society of Culture and Convergence, Cho Mingeun , Lee Byunghoon
Published: January 2023

The purpose of this study is to present the direction of the composition of spatial content in 3.15 Ocean Nuri Park. Through previous studies, water-friendly urban parks and placeness were systematically reviewed, and nine factors for forming placeness were derived. As a study method, case analysis and spatial content factor analysis of overseas water-friendly urban parks were conducted, focusing on the factors of placeness formation, and the study results are as follows. First, in order to revitalize the 3.15 Ocean Nuri Park, it is necessary to focus on the cultural environment, revitalization of the cultural community, and urban identity. Second, for a cultural environment capable of performing multiple functions, it is necessary to establish phased cultural facilities, improve water quality, solve noise problems, and secure visibility. Third, in order to revitalize the cultural community, it is necessary to expand community-linked activities and organize professional organizations. Fourth, in order to reflect urban identity, it is necessary to develop spatial content with spatial connection, historical exchange activities, and long-term persistence in the temporal context. Through this study, it was found that the placeness of water-friendly urban parks was activated with the frame of space-local culture-human-placeness.
Study on the Meaning of ‘Spring Night’ in Korean Modern Literature
Authors:   The Korean Society of Culture and Convergence, Lee Yeonhwa
Published: January 2023

As this study pays attention to the ‘difference’ that plays an important role to understand reality from the viewpoint of Kim Su-Young and Kwon Yeo-Seon, it examines the meaning of love in there works by being based on relationship with other people. This study has the purpose to examine the characteristics on the ethics of love in their works by through the theories of Levinas. Therefore, this study states a ‘difference’ that despair and collapse are not just terrible tragedies, but make an ethical love possible. The combination of opposing images in spring night becomes a crucial way that the writers represent reality based on the behavior of love on differences. Kim Su-Young and Kwon Yeo-Seon consider themselves as other people for enduring life and show the solidarity and love of other people. They also show that the way to do the ethical love, which keeps characteristics each other, is self-control.
Discrimination Discourse and Issue-Making covered by News Media: Topic Modeling of News Articles on Discrimination in Major National Daily Newspapers
Authors:   The Korean Society of Culture and Convergence, Lim Yonsoo
Published: January 2023

This study examined the discourse of discrimination composed by the media using topic modeling, focusing on news articles on discrimination reported in major national daily newspapers in Korea from 2010 to 2022. From the results, the discourse of discrimination was composed differently for each media company and the subject changed by period. It was changing from the comprehensive content of discrimination to specific detailed issues. The main discourse of discrimination was the controversy over discrimination and the issue of prohibition and abolition of discrimination. From a critical point of view, the problems and improvements of news media on discrimination were discussed. Furthermore, this study emphasized the need for practical efforts to move toward issue making, focusing on the problem-solving process.
An Inquiry into Possibility of Using Enneagram Spirituality in Addiction Recovery : Focusing on the Development of Human Consciousness
Authors:   The Korean Society of Culture and Convergence, Kang Sunkyung , Cha Youjeong
Published: January 2023

This study theoretically explored how Enneagram spirituality can be used, focusing on the development of human consciousness, on the premise of the addiction recovery paradigm that changes the overall attitude of addicts in life. Accordingly, it was proposed as an approach to spiritual development to improve the development levels of consciousness of Enneagram, which aims at vertical growth and development of humans. Specifically, the current status of addiction problems in modern society, addiction and addiction recovery, perspective on addiction, and relationship between addiction recovery and spirituality were examined, and through the overall understanding of the Enneagram theory, the theory of addiction recovery and consciousness development with Enneagram spirituality was explored. In addition, focusing on the development of consciousness of Gurdjieff and Riso, the possibility of using addiction recovery and spiritual development of the Enneagram was examined. However, as a growth method for self-transcendence, only comprehensive methods such as silence, meditation, prayer, and listening are presented. Therefore, the necessity of verification through differentiated programs and empirical studies according to the development levels of consciousness by types was proposed.
Analysis of Folk Culture Distribution in Weolaksan National Park Using QGIS: Focusing on Village Beliefs
Authors:   The Korean Society of Culture and Convergence, Kim Youngwan
Published: January 2023

This study proceeded an actual on-site investigation of folk cultures that are distributed around the area of Weolaksan National Park and nearby living cultural area, and, found out the details of tangible and intangible folk cultures including transmission through generations, changes by times, current existence and continuance, conservation status, etc. The folk cultures in Weolaksan National Park area is well conserved until now in a variety of traditional cultures such as village beliefs, traditional ritual rites, prayers' beliefs, tales and legends, etc. Those folk cultures found out by the on-site investigation was measured of their accurate locations using GPS and visually presented of their distributions on a map utilizing QGIS program. The study displayed folk cultures based on spatial analysis data and tried to utilize the data as material for conservation and protection of the cultural properties in the area of Weolaksan National Park living culture.
A Study on the Learning Community-Based School Musicals Teacher Training Program to Strengthen
Authors:   The Korean Society of Culture and Convergence, Kim Younghoo
Published: January 2023

The purpose of this study is to verify the effectiveness of the learning community-based school musical production teacher training program to strengthen teachers' creative convergence power, and to explore the experience and meaning of participating teachers. To this end, the Seoul Metropolitan Office of Education runs a 45-hour teacher training program called “Learning Actors” and is researching 15 elementary and secondary teachers who participated in the program. During the 15-week training period, teachers collaborate with local artists, display thematic expertise, and teach each other, while performing music at local venues for students, parents and fellow teachers. In order to measure the educational effect, a preliminary t-test was conducted on 15 subjects, and in-depth interviews, observations, and portfolios were analyzed. As a result of the study, this training program was meaningful in improving teachers' convergence teaching methods and partnerships with the community, while providing teachers' cooperative skills, understanding, insight into other subjects, and opportunities to reflect on life through arts activities.
A Study on Adhesive Recipes for Document Mending: Blending Pulgasari in Wheat Starch Paste
Authors:   The Korean Society of Culture and Convergence, Lee Jiyoung , Lee Sanghyun , Lee Jin
Published: January 2023

A study on adhesives for document mending was conducted by blending pulgasari(funori) with wheat starch paste. Pulgasari is usually used for the ‘facing’ process in paper conservation. 7 types of samples, shinpul, gopul, pulgasari blended adhesives were prepared and were applied on Hanji and their effect was assessed and quantified with instrumental methods. Adding pulgasari was shown effective to lower the artifact’s acidity and to increase the document’s flexibility. Adhesive force and viscosity and the degree of greenness and yellowness tended to rise as the ratio of pulgasari blended became higher. In microscopic observation, it showed less void and thicker film as the pulgasari ratio became higher. In the document mending experiment, the higher the ratio of pulgasari, the less stain and less contraction were shown. Blending pulgasari with wheat starch paste can be used as an alternative method to overcome the drawbacks of gopul and shinpul in document mending.
Knowledge domain and emerging trends in beta‐cell research: A bibliometric and knowledge‐map analysis
Authors: Luo Yunpeng , Wang Tong , Chen Zhuhong , Zhang Guangde
Published: January 2023

Background

Up to now, the physiology, pathology, and recovery of beta-cells have been intensively studied and made great progress, and these are of major significance for the treatment of related diseases. Nevertheless, a comprehensive and objective report on the status of beta-cell research is lacking. Therefore, this study aims to conduct a bibliometric analysis to quantify and identify the current status and trending issues in beta-cell research.

Methods

The articles and reviews related to beta-cell were obtained from the Web of Science Core Collection on August 31, 2022. Two scientometric software (CiteSpace 6.1.R3 and VOSviewer 1.6.18) were used to perform bibliometric and knowledge-map analysis.

Results

A total of 4098 papers were published in 810 academic journals in 2938 institutions from 83 countries/regions. The number of beta-cell-related publications was increasing steadily. The United States was the most productive country, while Universite libre de Bruxelles, University of Toronto and University of Geneva were the most active institutions. Diabetes published the most beta-cell studies and received the largest number of co-citations. Decio I Eizirik published the most papers and had the most co-citations. Twelve references on reviews and mechanisms were regarded as the knowledge base. Four major aspects of beta-cell research included the pathological mechanism of beta-cell failure, the recovery of beta cells, the risk factor related to beta cells, and the physiology of beta cells. Endoplasmic reticulum stress and oxidative stress have been core elements throughout the research in this field. In addition, beta-cell dedifferentiation, inflammation, autophagy, miRNA, and lncRNA are hot topics nowadays. Additionally, stem cell replacement therapies might be the alternative way to reverse beta-cell failure. Restoring beta-cell mass and function will remain a research goal in the future.

Conclusion

This study provided a comprehensive overview of beta-cell research through bibliometric and visual methods. The information would provide helpful references for scholars focusing on beta cells.
Impacts of biomass burning in Southeast Asia on aerosols over the low-latitude plateau in China: An analysis of a typical pollution event
Authors: Fan Wenxuan , Li Jie , Han Zhiwei , Wu Jian , Zhang Shuang , Zhang Chuwei , Li Jiawei
Published: January 2023

From March to April, widespread forest fires and agro-residue burning frequently occur in Southeast Asia, which release large amounts of gas species and aerosols and impact air quality over the wide source and downwind regions. In this study, we investigated the impact of biomass burning (BB) over Southeast Asia on particulate matter concentrations and aerosol properties in downwind areas of the low-latitude plateau from 1 March to 30 April 2019, with a focus on a typical pollution event in Kunming (KM), the capital of Yunnan Province, by using a wide variety of observations from the Chenggong ground monitoring station in Yunnan University, an air quality network in China, satellite retrievals and ERA-5 reanalysis data and numerical simulation. A regional pollution event contributed by BB pollutants from Southeast Asia and the India-Myanmar trough occurred in Yunnan Province on 31 March to 1 April 2019, which was the only typical pollution event that pollution transmission ran through central Yunnan Province from south to north since 2013, when the Airborne Pollution Action Plan was unveiled by China government. The daily mean PM2.5, PM1, and black carbon concentrations increased by 73.3 μg m−3(78%), 70.5 μg m−3 (80%), and 7.7 μg m−3 (83%), respectively, and the scattering and absorbing coefficients increased by 471.6 Mm−1 and 63.5 Mm−1, respectively, at the Chenggong station. The southwest winds exceeding 2 km vertically thick appeared in front of the India-Myanmar trough over the fire regions, pushing BB plumes northward into Yunnan Province. The model results show that 59.5% of PM2.5 mass produced by BB in Yunnan Province was sourced from the Myanmar-Thailand border, and 29.3% was from western Myanmar at a lower altitude (<4.9 km), which indicated that BB in the Myanmar-Thailand border was the dominant contributor.
ABI3BP is a prognosis biomarker related with clinicopathological features and immunity infiltration of lung tumor
Authors: Feng Yan , Han Xiaolei , Zhang Zhe , Qiao Han , Tang Huaping
Published: January 2023

Background: The primary factor of cancer mortality is lung tumor. ABI3BP gene encodes an extracellular matrix bind protein associated to multiplication and derivation. However, the prognosis score of ABI3BP for lung tumor and its relation with immunity cellular infiltration for lung tumor have not been reported.

Methods: Public repository systems (Timer, GEPIA, TCGA, HPA) were utilized to explore expression of ABI3BP for lung tumor, and explored the relation of ABI3BP and clinicopathological parameters. TCGA information set was utilized for cox analysis for data with one or more variables of ABI3BP for lung tumor. STRING was utilized to explore ABI3BP regulatory networks. GO/KEGG enrichment analysis as well as enrichment analysis of gene sets were carried out for ABI3BP co-expression via R package. And finally we explored the relation of expression of ABI3BP and lung tumor immunity invasion, exploring the influence of ABI3BP level of expression on immunotreatment and whether immunity invasion would affect the prognosis of patients with lung tumor.

Results: ABI3BP is downregulated in LUAD and LUSC, and associated to lung tumor phase and prognosis. Univariate and multivariate cox regression showed that ABI3BP was an independent prognostic factor in patients with lung tumors. The extracellular matrix protein-coding gene and the ABI3BP-related gene were intersected to obtain 10 hub genes. On the basis of GO/KEGG enrichment analysis, hub genes are closely associated to immunity-associated pathways including T cell receptor signaling pathway, immune response−activating cell surface receptor signaling pathway. Finally, the expression of ABI3BP is closely related to immune cell infiltration and immune cell marker set, and the expression of ABI3BP can help predict the therapeutic effect of immune checkpoint inhibitors and improve the prognosis of patients.

Conclusion: ABI3BP could be a new target for lung tumor that could be utilized as a diagnostic and therapeutic tool.
Research strategies in nutrition in health and disease: The failure of mechanistic research
Authors: Temple Norman J.
Published: January 2023

This paper critically evaluates different research methods in order to assess their value for establishing which dietary changes are most effective for protecting health and preventing disease. The evidence demonstrates that the combined use of observational studies (mainly cohort studies) and randomized controlled trials (RCTs) is the most successful strategy. Studies of the details of body mechanisms in health and disease (mechanistic research) is another commonly used research strategy. However, much evidence demonstrates that it is a far less successful strategy. In order to support the above conclusions research studies from the following areas are discussed: obesity and dietary fat; heart disease and saturated fat; the Mediterranean diet and cardiovascular disease; type 2 diabetes and dietary fiber; and cancer and micronutrients. While mechanistic research has a poor track record in nutrition, it has achieved some success in other areas of biomedical science. This is shown by examining the role of mechanistic research in the discovery of new drugs.
Immunotherapy and tumor mutational burden in cancer patients with liver metastases: A meta and real word cohort analysis
Authors: Wu Rui-Yan , Wang Bi-Cheng , Wang Kun , Xia Fan , Zhang Zhi-Yuan , Wan Jue-Feng , Zhang Zhen
Published: January 2023

Background

The predictive effects of liver metastases for immune-checkpoint inhibitors (ICIs) and the relationship between tumor mutational burden (TMB) and liver metastases (LM) remain unclear.

Methods

A systematic review and meta-analysis were conducted to explore the heterogeneity of ICIs efficacy between patients with or without LM. A pan-cancer cohort of 1,661 patients who received ICIs was downloaded and analyzed to assess the association between TMB and LM.

Results

Of 21053 studies identified in our search, eight single-arm studies and 24 randomized controlled trials were included. Overall, 17957 patients with advanced or metastatic cancers (4805 patients (26.8%) with LM and 13151 patients (73.2%) without LM) were enrolled. The pooled objective response rate (ORR) was 8.5% (95% CI 4%–13%) in the LM group versus 21% (95% CI 16%–21%) in the non-LM group. The pooled hazard ratio (HR) for death was 0.85 (95% CI 0.80–0.90) in the LM group treated with ICIs compared with the standard of care. In patients without LM who were treated with ICIs, the pooled HR for death was 0.78 (95% CI 0.73–0.82) compared with the standard of care. The difference in efficacy between patients with or without LM treated with ICIs was significant (p=0.04). Pan-cancer analysis revealed that the TMB-high rate was 10.8% in liver metastatic lesions versus 21.4% in other metastatic lesions (p=0.004). In addition, TMB was also significantly associated with OS as a binary cutoff (p=0.05) and was an independent prognostic variable (HR=0.98, P=0.047) as a continuous variable in patients with LM.

Conclusions

In patients with LM, the efficacy of immunotherapy was attenuated, but TMB-high could predict better survival outcomes.
Feiyiliu Mixture sensitizes EGFRDel19/T790M/C797S mutant non-small cell lung cancer to osimertinib by attenuating the PRC1/Wnt/EGFR pathway
Authors: Shi Jingjing , Hao Shaoyu , Liu Xiantao , Li Yingying , Zheng Xin
Published: January 2023

Introduction: Osimertinib is a potent epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) for the treatment of patients with EGFR-mutant non-small cell lung cancer (NSCLC). However, the emergence of acquired resistance due to the EGFR-Del19/T790M/C797S mutation limits the clinical application of osimertinib. Feiyiliu Mixture (FYLM), a clinical experience formula of Chinese medicine, was used to treat lung cancer with good clinical efficacy. In this study, we aimed to investigate the mechanism by which Feiyiliu Mixture delays osimertinib resistance in EGFR-mutant cell lines and EGFR-mutant cell tumor-bearing mice.

Methods: The osimertinib-resistant cell models were established in mouse Lewis lung carcinoma (LLC) cells transfected with EGFR-Del19/T790M/C797S mutant lentivirus. In cell experiments, after 48 h of treatment with Feiyiliu Mixture-containing serum, MTT assay was used to detect the relative cell viability, and western blotting was used to detect EGFR protein phosphorylation expression. In animal experiments, C57BL/6J mice were subcutaneously injected with Lewis lung carcinoma cells stably expressing EGFR-Del19/T790M/C797S mutations to construct a xenograft model. After 2 weeks of Feiyiliu Mixture and/or osimertinib treatment, the expression of proliferation-related, apoptosis-related and PRC1/Wnt/EGFR pathway markers was detected by real-time qPCR, western blotting and immunohistochemistry.

Results: The results showed that when combined with osimertinib, Feiyiliu Mixture synergistically reduces proliferation and increases apoptosis to improve drug resistance. In vitro, Feiyiliu Mixture-containing serum reduced the EGFR phosphorylation. In vivo, Feiyiliu Mixture downregulated the expression of cyclin B1 and Bcl-2 while upregulating the level of cleaved Caspase-3 protein, indicating that Feiyiliu Mixture promotes apoptosis. Furthermore, Feiyiliu Mixture reduced the expression of p-EGFR, p-Akt, PRC1 and Wnt pathway-related proteins such as β-catenin, c-Myc and c-Jun.

Conclusion: The present study identified that Feiyiliu Mixture inhibited PRC1/Wnt/EGFR pathway activation, reduced proliferation, and promoted apoptosis, thereby increasing the sensitivity of EGFR-mutant non-small cell lung cancer to osimertinib. Our study provided a new idea for Chinese medicine to play a role in enhancing efficacy and reducing toxicity in the treatment of non-small cell lung cancer.
Inhalation of virus-loaded droplets as a clinically plausible pathway to deep lung infection
Authors: Chakravarty Aranyak , Panchagnula Mahesh V. , Patankar Neelesh A.
Published: January 2023

Respiratory viruses, such as SARS-CoV-2, preliminarily infect the nasopharyngeal mucosa. The mechanism of infection spread from the nasopharynx to the deep lung–which may cause a severe infection—is, however, still unclear. We propose a clinically plausible mechanism of infection spread to the deep lung through droplets, present in the nasopharynx, inhaled and transported into the lower respiratory tract. A coupled mathematical model of droplet, virus transport and virus infection kinetics is exercised to demonstrate clinically observed times to deep lung infection. The model predicts, in agreement with clinical observations, that severe infection can develop in the deep lung within 2.5–7 days of initial symptom onset. Results indicate that while fluid dynamics plays an important role in transporting the droplets, infection kinetics and immune responses determine infection growth and resolution. Immune responses, particularly antibodies and T-lymphocytes, are observed to be critically important for preventing infection severity. This reinforces the role of vaccination in preventing severe infection. Managing aerosolization of infected nasopharyngeal mucosa is additionally suggested as a strategy for minimizing infection spread and severity.
The intervention of Brain Gym in the mathematical abilities of high-school students: A pilot study
Authors: Ramos-Galarza Carlos , Aymacaña-Villacreses Cristina , Cruz-Cárdenas Jorge
Published: January 2023

Introduction

The learning process of Mathematics is a challenge in Latin America; therefore, it is of vital importance to conduct actions that improve the performance in this science.

Methods

This article is reporting on quasi-experimental research, where, through the use of Brain Gym, the objective is to improve: the definition of rational numbers, problem-solving ability, mathematical order relationships, and equivalent fractions. We worked with 67 students between 12 and 14 years old, organized into an experimental group (n = 35) and a control group (no participation group; n = 32).

Results

We made pre and post-test measurements and found that the control group students improved in their problem-solving ability F(1,65) = 8.76, p = 0.04, η2 = 0.12 and equivalent fractions F(1,65) = 4.54, p = 0.03, η2 = 0.06.

Discussion

In conclusion, the importance of applying innovative processes to improve the teaching and learning of Mathematics can be affirmed. It is important to note that both the control and experimental groups improved their learning, however, the experimental group did so to a greater extent than the students in the control group, who received a traditional educational process, and they did learn, but not at the level of the experimental group.
Development of social anxiety cognition scale for college students: Basing on Hofmann’s model of social anxiety disorder
Authors: Zha Yuxin , Tang Qin , Jin Xiaoru , Cai Xinfei , Gong Wen , Shao Yongcong , Weng Xiechuan
Published: January 2023

Introduction

To develop the Chinese version of the Social Anxiety Cognition Scale for College Students (SACS-CS) based on Hofmann’s model of social anxiety disorder and examine its reliability and validity.

Methods

Based on literature analysis and structured interviews, a theoretical model was constructed and behavioral examples were collected. According to the results of participants’ and experts’ evaluations, the initial SACS-CS was developed. The study data were collected from a total of 500 valid participants, randomly divided into two samples. Sample 1 (n = 200) and sample 2 (n = 300) were considered for exploratory factor analysis and confirmatory factor analysis (CFA), respectively. Internal reliability and validity were examined using all 500 participants, and temporal reliability was established using sample 3 (n = 70), who completed the scale again after 4 weeks.

Results

The SACS-CS consists of 21 items, grouped under four factors: self-perception, social skills, emotional control, and cost estimation. The four-factor model fits well. The internal consistency coefficient of the scale and the four factors ranged from 0.87 to 0.96, and the test–retest reliability ranged from 0.76 to 0.84. The scores of the scale and the four factors were significantly correlated with the score of the Interaction Anxiousness Scale (r = 0.54–0.64).

Discussion

The SACS-CS possesses good reliability and validity and can be applied in the cognitive assessment of college students’ social anxiety. The scale could help people with different social anxiety disorder conditions receive more personalized interventions.