bluuebunny/crossref_metadata_2025 huggingface dataset:
ChemInform Abstract: Practical and Highly Selective C—H Functionalization of Structurally Diverse Ethers.
Authors: Wan Miao , Meng Zhilin , Lou Hongxiang , Liu Lei
Published: April 2015

Alkynylations, arylations and alkenylations of a broad variety of substrates (including cyclic and acyclic ethers and various heterocyclic substrates) are achieved.
ChemInform Abstract: Ni(II)‐Catalyzed Oxidative Coupling Between C(sp2)—H in Benzamides and C(sp3)—H in Toluene Derivatives.
Authors: Aihara Yoshinori , Tobisu Mamoru , Fukumoto Yoshiya , Chatani Naoto
Published: April 2015

A unique method for the highly ortho‐regioselective benzylation of N‐quinolin‐8‐yl substituted benzamides by using the Ni‐catalyzed oxidative coupling of the ortho C‐H bond with a variety of methylarenes is developed.
ChemInform Abstract: Regioselective Synthesis of Vinyl Halides, Vinyl Sulfones, and Alkynes: A Tandem Intermolecular Nucleophilic and Electrophilic Vinylation of Tosylhydrazones.
Authors: Ojha Devi Prasan , Prabhu Kandikere Ramaiah
Published: April 2015

The reaction of tosylhydrazones with N‐halosuccinimide and tetraalkylammonium halide at 90 °C gives rise to vinyl halides (VI), whilst the reaction at 110°C affords alkynes (X).
ChemInform Abstract: A General Catalytic Route to Isoindolinones and Tetrahydroisoquinolines: Application in the Synthesis of (.+‐.)‐Crispine A.
Authors: Dhanasekaran Sivasankaran , Bisai Vishnumaya , Unhale Rajshekhar A. , Suneja Arun , Singh Vinod K.
Published: April 2015

The reactions can also be performed using Zn(OTf)2 or Cu(OTf)2 for the synthesis of isoindoles or isoquinolines, respectively.
ChemInform Abstract: Copper‐Catalyzed Propargylic Substitution of Dichloro Substrates: Enantioselective Synthesis of Trisubstituted Allenes and Formation of Propargylic Quaternary Stereogenic Centers.
Authors: Li Hailing , Grassi David , Guenee Laure , Buergi Thomas , Alexakis Alexandre
Published: April 2015

An easy and versatile Cu‐catalyzed propargylic substitution process is presented.
ChemInform Abstract: Palladium‐Catalyzed Direct Amination of Allylic Alcohols at Room Temperature.
Authors: Wang Maorong , Xie Yinjun , Li Jiawen , Huang Hanmin
Published: April 2015

A palladium complex efficiently allows the direct amination of allylic alcohols with amines at room temperature without further additives.
ChemInform Abstract: N‐Substituted Glycines with Functional Side‐Chains for Peptoid Synthesis.
Authors: Rene Adeline , Martinez Jean , Cavelier Florine
Published: April 2015

The title species (V) and (VIII) are prepared from amines (I) via persilylation used for temporary protection, alkylation with ester (II), N‐protection and ester cleavage.
ChemInform Abstract: Solvent‐Free Mechanochemical Conversion of 3‐Ethoxysalicylaldehyde and Primary Aromatic Amines to Corresponding Schiff‐Bases.
Authors: Tigineh Getinet Tamiru , Wen Yuh‐Sheng , Liu Ling‐Kang
Published: April 2015

The grinding‐approach to Schiff‐bases tolerates diversely functionalized aryl amines and does not require any work‐up or purification procedures.
ChemInform Abstract: Domino Hydroformylation/Aldol Condensation/Hydrogenation Catalysis: Highly Selective Synthesis of Ketones from Olefins.
Authors: Fang Xianjie , Jackstell Ralf , Boerner Armin , Beller Matthias
Published: April 2015

A general and highly chemo‐ and regioselective synthesis of ketones from olefins by domino hydroformylation/aldol condensation/hydrogenation reaction is developed.
ChemInform Abstract: Cu(II)/TBAI‐Catalyzed Esterification of Acid Hydrazides via C(sp3)—H Oxidative Coupling.
Authors: Liu Guifeng , Jin Can , Wu Guomin
Published: April 2015

The reaction works with aroyl hydrazides and cycloalkanes only.
ChemInform Abstract: Metal‐Free Hydroacyloxylation and Hydration Reactions of Ynamides: Synthesis of α‐Acyloxyenamides and N‐Acylsulfonamides.
Authors: Xu Shijie , Liu Jianquan , Hu Donghua , Bi Xihe
Published: April 2015

Starting from ynamides [(I), (VI), (VIII), and (XI), resp.], α‐oxyenamides [(III), (V), (VII), or (IX), resp.] or N‐acylsulfonamides [(X), (XII), or (XIII), resp.] are simply and efficiently synthesized.
ChemInform Abstract: An Odorless, One‐Pot Synthesis of Nitroaryl Thioethers via SNAr Reactions Through the in situ Generation of S‐Alkylisothiouronium Salts.
Authors: Lu Guo‐ping , Cai Chun
Published: April 2015

The nonionic surfactant Triton X‐100, which self‐assembles in water to form micelles, proves to enhance the title reaction remarkably.
ChemInform Abstract: Hydroarylations of Heterobicyclic Alkenes Through Rhodium‐Catalyzed Directed C—H Functionalizations of S‐Aryl Sulfoximines.
Authors: Dong Wanrong , Parthasarathy Kanniyappan , Cheng Ying , Pan Fangfang , Bolm Carsten
Published: April 2015

Rhodium‐catalyzed directed CH‐functionalizations are used in hydroarylations of heterobicyclic alkenes with NH‐sulfoximines.
ChemInform Abstract: Metal‐Free Enantioselective Electrophilic Activation of Allenamides: Stereoselective Dearomatization of Indoles.
Authors: Romano Ciro , Jia Minqiang , Monari Magda , Manoni Elisabetta , Bandini Marco
Published: April 2015

The reaction can be applied in a one‐pot dearomatization/hydrogen‐transfer cascade reaction giving trans‐indolines (XII) in good yields and with high stereoselectivities.
ChemInform Abstract: Rhodium‐Catalyzed Oxidative Annulation of Hydrazines with Alkynes Using a Nitrobenzene Oxidant.
Authors: Li Deng Yuan , Chen Hao Jie , Liu Pei Nian
Published: April 2015

The rhodium‐catalyzed oxidative annulation of aromatic hydrazines with various alkynes affords aminoindol derivatives.
ChemInform Abstract: Copper‐Catalyzed Direct C—H Arylation of Thieno[3,4‐c]pyrrole‐4,6‐dione (TPD): Toward Efficient and Low‐Cost Synthesis of π‐Functional Small Molecules.
Authors: Song Yi‐Ting , Lin Po‐Han , Liu Ching‐Yuan
Published: April 2015

A broad variety of functional groups is tolerated.
ChemInform Abstract: Access to trans‐3,4‐Dihydroxy‐2‐alkylpyrrolidines and Piperidines by Use of Stereodefined Cyclic N,O‐Acetals as a Diversity‐Generating Element.
Authors: Kang Soyeong , Kim Dong‐gil , Rhee Young Ho
Published: April 2015

A highly efficient and stereoselective synthetic pathway towards trans‐3,4‐dihydroxy‐2‐alkylpyrrolidines and piperidines is described.
ChemInform Abstract: Direct Intramolecular Catalytic Enantioselective Alkylation of Oxazolidinone Bromoalkanoate Imides.
Authors: De Rycke Nicolas , St Denis Jeffrey D. , Hughes Jonathan M. E. , Rosadiuk Kristopher A. , Gleason James L.
Published: April 2015

The catalytic intramolecular alkylation of oxazolidinone imides is conducted in presence of MgBr2.OEt2 combined with a pyridine‐bisoxazoline ligand.
ChemInform Abstract: Tandem Synthesis of 3‐Halo‐5‐Substituted Isoxazoles from 1‐Copper(I) Alkynes and Dihaloformaldoximes.
Authors: Chen Wenwen , Wang Bo , Liu Nan , Huang Dayun , Wang Xinyan , Hu Yuefei
Published: April 2015

The scalable, base‐free tandem synthesis proceeds regioselectively and offers a practical alternative to the established 1,3‐dipolar cycloaddition.
ChemInform Abstract: Lewis Base Catalyzed Aerobic Oxidative Intermolecular Azide‐Zwitterion Cycloaddition.
Authors: Li Wenjun , Wang Jian
Published: April 2015

The discovery of a novel aerobic oxidative intermolecular azide—zwitterion reaction catalyzed by an organocatalyst is presented.
ChemInform Abstract: DABCO‐Functionalized Mesoporous SBA‐15: An Efficient and Recyclable Catalyst for the Synthesis of Spiro‐Pyranoxindoles as Antioxidant Agents.
Authors: Azimi Razieh , Baharfar Robabeh
Published: April 2015

The catalyst is recyclable and reusable at least 2 times though the amount of recovered catalyst is reduced.
ChemInform Abstract: Copper(II) Acetate Catalyzed Ullmann‐Type C—O Coupling Reaction of Phenols with 4‐Tosylcoumarin.
Authors: Alizadeh Abdolali , Ghanbaripour Rashid
Published: April 2015

A protocol for the ligand‐free copper acetate‐catalyzed synthesis of 4‐aryloxycoumarins is reported.
ChemInform Abstract: Rhodium‐Catalyzed Chemo‐, Regio‐, and Enantioselective Addition of 2‐Pyridones to Terminal Allenes.
Authors: Li Changkun , Kaehny Matthias , Breit Bernhard
Published: April 2015

The reaction is applied in the synthesis of a precursor (X) of known glucokinase activators.
ChemInform Abstract: A One‐Pot Copper Catalyzed Biomimetic Route to N‐Heterocyclic Amides from Methyl Ketones via Oxidative C—C Bond Cleavage.
Authors: Subramanian Parthasarathi , Indu Satrajit , Kaliappan Krishna P.
Published: April 2015

A direct and efficient one‐pot Cu‐catalyzed biomimetic oxidation of readily available methyl ketones to pharmaceutically important N‐heterocyclic amides is reported.
ChemInform Abstract: A Practical and Mild Chlorination of Fused Heterocyclic N‐Oxides.
Authors: Wang Dong , Jia Hailing , Wang Wuchang , Wang Zhe
Published: April 2015

The Vilsmeier reagent is employed as both activating agent and nucleophilic chloride source for the regioselective chlorination of quinoline‐ and isoquinoline‐N‐oxides.
ChemInform Abstract: Facile Synthesis of Iron Oxide NPs as Magnetically Recyclable Catalysts for Chemoselective Synthesis of Pyrazolo[3,4‐b]pyridine‐5‐carbonitiles in Aqueous Medium under Ultrasonic Irradiation.
Authors: Dandia Anshu , Parewa Vijay , Sharma Amit , Rathore Kuldeep S.
Published: April 2015

The employed catalyst can be easily recovered by a magnetic field and reused five times without any loss of its high catalytic activity.
ChemInform Abstract: A Novel and Facile Synthesis of 2‐Oxo‐1,2‐dihydropyridine‐Fused 1,3‐Diazaheterocycles via Heterocyclic Ketene Aminals and Knoevenagel Adducts Formed by Phthalic Anhydride and Ethyl Cyanacetate.
Authors: Zou Min‐Ming , Zhu Feng‐Juan , Tian Xue , Ren Li‐Ping , Shao Xu‐Sheng , Li Zhong
Published: April 2015

This referred transformation presents a novel way for the construction of 2‐oxo‐1,2‐dihydropyridine‐fused 1,3‐diazaheterocycles.
ChemInform Abstract: An Efficient Synthesis of 1‐Oxo‐1,2‐dihydrobenzo[b][1,6]naphthyridine‐4‐carbonitriles.
Authors: Wang Dao‐Lin , Wu Jian‐Ying , Wu Dan , Wang Yong‐Yang
Published: April 2015

The title compounds (V) are obtained via tandem addition‐elimination‐cyclization reaction of quinoline‐3‐carboxylate derivatives (III) with primary amines (IV).
ChemInform Abstract: Broensted Acid Mediated Alkenylation and Copper‐Catalyzed Aerobic Oxidative Ring Expansion/Intramolecular Electrophilic Substitution of Indoles with Propargyl Alcohols: A Novel One‐Pot Approach to Cyclopenta[c]quinolines.
Authors: Gangadhararao G. , Uruvakilli Anasuyamma , Swamy K. C. Kumara
Published: April 2015

The method is not applicable to N‐unprotected indole derivatives.
ChemInform Abstract: An Unprecedented Tandem Annulation of ω‐Azido‐1‐alkynes with Diaryliodonium Salts: A Facile Synthesis of Polycyclic Quinolines.
Authors: Chen Junjie , Chen Chao , Chen Jing , Gao Hongpeng , Qu Hongmei
Published: April 2015

The copper‐catalyzed annulation of azidoalkynes with diaryliodonium triflates, serving as C‐2 building blocks, proceeds smoothly and under mild conditions.
ChemInform Abstract: A Convenient and Green Approach for the Synthesis of 2H‐Indazolo[2,1‐b]phthalazinetriones
Authors: Raghuvanshi Dushyant Singh , Kumari Kumkum , Allam Bharat Kumar , Sing Krishna Nand
Published: April 2015

via a multicomponent reaction
ChemInform Abstract: Ultrasound‐Promoted One‐Pot Synthesis of 2‐Thioxo‐dihydropyrimidine Derivatives Bearing Piperidinylamide Moiety.
Authors: Chen Bao‐Hua , Li Ji‐Tai , Lan Rui‐Jia , Chen Guo‐Feng
Published: April 2015

The title compounds (IV) are obtained by convenient and efficient one‐pot condensation of 1,3‐dione (I) with various aromatic aldehydes (II) and thiourea (III) under mild reaction conditions.
ChemInform Abstract: Facile Synthesis of Novel N4‐Substituted 2‐(Trifluoromethyl)‐tetrahydrobenzothieno[ 2,3‐d]pyrimidine Derivatives.
Authors: Wang Fasong , Gao Hui , Yang Ping , Wang Yan , Song Xinjian
Published: April 2015

The title compounds are obtained by a facile three‐step synthesis starting from easily accessible starting materials under mild reaction conditions.
ChemInform Abstract: Preparation of Pyrido[2,3‐b]pyrazine Ring System via Regioselective Condensation Reaction.
Authors: Kekesi Laszlo , et al.
Published: April 2015

of 2,3‐diaminopyridine (I) and arylacetaldehydes (II)
ChemInform Abstract: A Cascade of Acid‐Promoted C—O Bond Cleavage and Redox Reactions: From Oxa‐Bridged Benzazepines to Benzazepinones.
Authors: Zhang Yuewei , Yang Fengzhi , Zheng Lianyou , Dang Qun , Bai Xu
Published: April 2015

The synthetic potential of the method is demonstrated by the transformation of compound (X) into the drug tolvaptan (XI).
ChemInform Abstract: A Catalyst‐Free Synthesis of α‐Aminophosphonates in Glycerol.
Authors: Azizi Kobra , Karimi Meghdad , Heydari Akbar
Published: April 2015

Kabachnik—Fields reaction of carbonyl compounds, amines, and phosphites in glycerol as solvent affords α‐aminophosphonates in high yields.
ChemInform Abstract: Synthesis of a Common Cyclopentanoid Building Block for the Total Synthesis of Jatropha‐5,12‐ and ‐6(17),11‐dienes by Uncatalyzed Intramolecular Carbonyl Ene (ICE) Reaction.
Authors: Butt Lena , Hiersemann Martin
Published: April 2015

Key intermediates (I) and (II) serve as building blocks for attempted syntheses of euphoheliosnoid D (III) and euphodendoridin D (IV).
ChemInform Abstract: Tirucallane‐Type Triterpenoids from Celastrus stylosus Wall.
Authors: Shan Wei‐Guang , Gao Zai‐Lin , Ying You‐Min , Xiang Jia‐Gui , Wang Fa‐Song , Zhan Zha‐Jun
Published: April 2015

isolation and structure elucidation of two new tirucallane‐type triterpenoids (I) and (II)
ChemInform Abstract: Total Synthesis and Determination of the Absolute Configuration of Rakicidin A.
Authors: Chen Yue , et al.
Published: April 2015

Rakicidin A, a natural cyclic depsipeptide possessing unique growth inhibitory activity against chronic myelogenous leukemia stem cells is synthesized in a stereoselective fashion allowing the assignment of the absolute stereochemistry of its five chiral centers.
ChemInform Abstract: Flavonol Glycosides and Iridoids from Asperula lilaciflora
Authors: Kirmizibekmez Hasan , Bardakci Hilal , Masullo Milena , Kamburoglu Oezge , Eryilmaz Gonca , Akaydin Galip , Yesilada Erdem , Piacente Sonia
Published: April 2015

isolation and structure elucidation of a new flavonol glycoside, named lilacifloroside (I), and a new iridoid, named asperulogenin (II), along with eight known compounds
ChemInform Abstract: Evollionines A—C, Three New Alkaloids Isolated from the Fruits of Evodia rutaecarpa.
Authors: Li Yan‐Hong , He Juan , Li Yan , Wu Xing‐De , Peng Li‐Yan , Du Ru‐Nan , Cheng Xiao , Zhao Qin‐Shi , Li Rong‐Tao
Published: April 2015

Three new alkaloids, evollionines A (I), B (II), and C (III), are isolated together with two known compounds, evodianinine and wuzhuyumide I.
ChemInform Abstract: New Acetogenins from the Seeds of Annona coriacea.
Authors: da C. Alves Thayana , Goncalves Mariele R. S. , Correia Francyne C. S. , da Silva Virginia C. , de Sousa Paulo T. Jr. , de Carvalho Mario G. , Braz‐Filho Raimundo , Dall'Oglio Evandro L.
Published: April 2015

isolation and structure elucidation of two novel acetogenins, coriapentocins A (I) and B (II)
ChemInform Abstract: Asymmetric Syntheses of (—)‐3‐epi‐Fagomine, (2R,3S,4R)‐Dihydroxypipecolic Acid, and Several Polyhydroxylated Homopipecolic Acids.
Authors: Csatayova Kristina , Davies Stephen G. , Fletcher Ai M. , Ford J. Gair , Klauber David J. , Roberts Paul M. , Thomson James E.
Published: April 2015

The target compounds are synthesized using diastereoselective olefinic oxidations of enantiopure tetrahydropyridines.
ChemInform Abstract: Flavonoids and Arylbenzofurans from the Rhizomes and Roots of Sophora tonkinensis with IL‐6 Production Inhibitory Activity.
Authors: Yoo Hunseung , Chae Hee‐Sung , Kim Young‐Mi , Kang Minseok , Ryu Keun Ho , Ahn Hee Chul , Yoon Kee Dong , Chin Young‐Won , Kim Jinwoong
Published: April 2015

Three new flavenoids, 2′‐hydroxyglabrol (I), 3‐methylmaackiapterocarpan B (II), and (III), are isolated along with 20 known compounds from the rhizomes and roots of Sophora tonkinensis.
ChemInform Abstract: Tanzawaic Acid Derivatives from a Marine Isolate of Penicillium sp. (SF‐6013) with Antiinflammatory and PTP1B Inhibitory Activities.
Authors: Quang Tran Hong , Ngan Nguyen Thi Thanh , Ko Wonmin , Kim Dong‐Cheol , Yoon Chi‐Su , Sohn Jae Hak , Yim Joung Han , Kim Youn‐Chul , Oh Hyuncheol
Published: April 2015

The new tanzawaic acid derivative, 2E,4Z‐tanzawaic acid D (I), is isolated along with four known analogues from the marine‐derived fungus Penicillium sp.
ChemInform Abstract: What Restricts Gold Clusters Reactivity in Catalysis and Gas Sensing Effects: A Focused Review
Authors: Korotcenkov G. , Brinzari V. , Cho B. K.
Published: April 2015

Review: 62 refs.
ChemInform Abstract: Organic Chemistry One Catalyst, Two Reactions
Authors: Schulz Emmanuelle
Published: April 2015

Review: 6 refs.
ChemInform Abstract: P‐Chirogenic Organophosphorus Acid‐Bases in Asymmetric Organocatalysis
Authors: Remond Emmanuelle , Juge Sylvain
Published: April 2015

Review: 74 refs.
ChemInform Abstract: Recent Advances in C—Si Bond Activation via a Direct Transition Metal Insertion
Authors: Li Linjie , Zhang Yuebao , Gao Lu , Song Zhenlei
Published: April 2015

Review: [27 refs.
ChemInform Abstract: γ‐(S)‐Trifluoromethyl Proline: Evaluation as a Structural Substitute of Proline for Solid State 19F‐NMR Peptide Studies
Authors: Kubyshkin Vladimir , Afonin Sergii , Kara Sezgin , Budisa Nediljko , Mykhailiuk Pavel K. , Ulrich Anne S.
Published: April 2015

Review: [47 refs.
ChemInform Abstract: Structurally Simple Complexes of CO2
Authors: Murphy Luke J. , Robertson Katherine N. , Kemp Richard A. , Tuononen Heikki M. , Clyburne Jason A. C.
Published: April 2015

Review: 169 refs.
ChemInform Abstract: Ligand‐Controlled Gold Catalyzed Highly Site‐Selective Carbene Transfer in C—H Bond Formation
Authors: Yi Hong , Lei Ai‐Wen
Published: April 2015

Review: 5 refs.
ChemInform Abstract: The Frequent Application of Multicomponent and Cycloaddition Reactions for the Synthesis of Potent MDM2‐p53 Inhibitors.
Authors: Gollner Andreas
Published: April 2015

Review: [41 refs.
ChemInform Abstract: Cp*CoIII‐Catalyzed C—H Activation of (Hetero)arenes: Expanding the Scope of Base‐Metal‐Catalyzed C—H Functionalizations
Authors: Yoshikai Naohiko
Published: April 2015

Review: 20 refs.
ChemInform Abstract: Hydrolase‐Catalyzed Asymmetric Carbon—Carbon Bond Formation in Organic Synthesis
Authors: Guan Zhi , Li Ling‐Yu , He Yan‐Hong
Published: April 2015

Review: 86 refs.
ChemInform Abstract: Supramolecular Architectures Incorporating Hydrogen‐Bonding Barbiturate Receptors
Authors: Tron Arnaud , Rocher Mathias , Thornton Peter J. , Tucker James H. R. , McClenaghan Nathan D.
Published: April 2015

Review: [53 refs.
ChemInform Abstract: Stoichiometric Copper or Silver Salt‐Mediated Oxidative C—H/C—H Cross‐Coupling Reactions
Authors: Dong Jiaxing , Wu Qian , You Jingsong
Published: April 2015

Review: [20 refs.
ChemInform Abstract: Zinc Reagents as Non‐noble Catalysts for Alkyne Activation
Authors: Gonzalez Maria J. , Lopez Luis A. , Vicente Ruben
Published: April 2015

Review: [55 refs.
ChemInform Abstract: Recent Advances on Ester Synthesis via Transition‐Metal Catalyzed C‐H Functionalization
Authors: Liu Bin , Hu Fang , Shi Bing‐Feng
Published: April 2015

Review: 158 refs.
ChemInform Abstract: Nickel: The “Spirited Horse” of Transition Metal Catalysis
Authors: Ananikov Valentine P.
Published: April 2015

Review: 116 refs.
ChemInform Abstract: Comparative in Operando Studies in Heterogeneous Catalysis: Atomic and Electronic Structural Features in the Hydrogenation of Ethylene over Supported Pd and Pt Catalysts
Authors: Jung Ulrich , Elsen Annika , Li Yuanyuan , Smith Jeremy G. , Small Matthew W. , Stach Eric A. , Frenkel Anatoly I. , Nuzzo Ralph G.
Published: April 2015

Review: 111 refs.
ChemInform Abstract: Synthesis of Pteridines Derivatives from Different Heterocyclic Compounds
Authors: Ahmed Sayed A. , Elghandour Ahmed H. , Elgendy Hussein S.
Published: April 2015

Review: 88 refs.
ChemInform Abstract: Recent Applications of Rare‐Earth Metal(III) Triflates in Cycloaddition and Cyclization Reactions
Authors: Ladziata Uladzimir
Published: April 2015

Review: 90 refs.
ChemInform Abstract: Regio‐ and Stereoselective Syntheses and Cycloadditions of Substituted 2H‐Pyran‐2‐ones and Their Fused Derivatives
Authors: Kranjc Kristof , Kocevar Marijan
Published: April 2015

Review: 102 refs.
ChemInform Abstract: Counterion Effects in Homogeneous Gold Catalysis
Authors: Jia Minqiang , Bandini Marco
Published: April 2015

Review: 169 refs.
ChemInform Abstract: Synthetic Chemistry Fuels Interdisciplinary Approaches to the Production of Artemisinin
Authors: Corsello Michael A. , Garg Neil K.
Published: April 2015

Review: 59 refs.
Contribution of Methane Benthic and Atmospheric Fluxes of an Experimental Area (Sitka Stream)
Authors: Bednařík Adam , Čáp Lubomír , Maier Vítězslav , Rulík Martin
Published: April 2015

Contributions of methane benthic fluxes and methane emissions to the total methane amount were studied during the summer season for two consecutive years. Considering the fact that methane is produced in great amount within hyporheic sediments, we have expected that both methane released by the benthic fluxes into the overlying water and methane emitted to the atmosphere should significantly affect the total methane budget of the stream water within the experimental area. In order to asses this assumption, we measured methane concentrations within the vertical sediment profile of a hyporheic zone, direct benthic methane fluxes by static chambers, methane concentrations in the surface water, and methane emissions into the atmosphere simultaneously. The methane concentrations in interstitial water tended sharply to increase with sediment depth (0.54–734.99 μmol L−1) and were strongly correlated with benthic fluxes (r = 0.88, p < 0.05). We also found a considerable variability in the benthic methane fluxes (0–12.59 mmol m−2 day−1) and the spatial variability (0–71.43%) of the experimental area, suggesting that there may be various factors that affect the rate of benthic fluxes including methanotrophy in the top sediment layers. Generally, the contribution of benthic fluxes and methane emissions to the methane budgets of the experimental area was negligible (0.034 (0.45%) and 0.074 mol day−1 (0.98%), respectively).
Multivariate Empirical Mode Decomposition Derived Multi‐Scale Spatial Relationships between Saturated Hydraulic Conductivity and Basic Soil Properties
Authors: She Dongli , Zheng Jiaxing , Shao Ming'an , Timm Luis Carlos , Xia Yongqiu
Published: April 2015

Saturated hydraulic conductivity (Ks) is affected by various factors operating at different scales. This study identified the multi‐scale spatial relationships between Ks and selected basic soil properties (soil organic matter [SOM], clay, silt, and sand contents, and bulk density) along two landscape transects (with various soil textures and land use covers) on the Loess Plateau. Multivariate empirical mode decomposition (MEMD) yielded four different intrinsic mode functions (IMFs) for the multivariate data series of each transect according to the scale of occurrence. The dominant scales in terms of explained variance of Ks were IMF1 (scale: 403 m) for transect 1, and IMF1 and IMF2 (scale: 407 and 775 m) for transect 2. The multi‐scale correlation between Ks and soil properties was more complex for transect 1 due to a more fragmented landscape. For each IMF or residue, Ks was predicted using the identified factors that significantly affected it at that IMF scale or residue. The summation of the four predicted IMFs and the residue predicted Ks at the measurement scale, and was more accurate than predictions based on simple multiple linear regressions between Ks and the other soil properties. Soil particle size components were the main contributors in explaining Ks variability for both landscape transects, mostly due to their contributions from IMF1; however, SOM was also a major contributor for transect 2, mainly due to contributions from IMF2. Using MEMD has great potential in characterizing scale‐dependent spatial relationships between soil properties in complicated landscape ecosystems.
Interaction of Vermiculite with Pb(II), Cd(II), Cu(II) and Ni(II) Ions in Single and Quaternary Mixtures
Authors: Vijayaraghavan Kuppusamy , Raja Franklin D.
Published: April 2015

In this study, single and competitive sorption of Pb(II), Cd(II), Cu(II), and Ni(II) ions onto vermiculite were studied. Preliminary examination revealed that vermiculite possesses low bulk density (279 kg/m3), a high cation exchange capacity (41.3 meq/100 g), water holding capacity (62.5%), and air‐filled porosity (5.8%). The pH edge experiments indicated that the uptake capacity of vermiculite improved with enhancement in pH and highest value was detected at pH 5. Fourier transform IR spectroscopy along with scanning electron microscopy and energy dispersive X‐ray spectroscopy confirmed changes in the sorbent functionality after metal sorption, and the results were in agreement with metal removal studies. It was observed by isotherm experiments that vermiculite was capable of sorbing 0.238, 0.099, 0.199 and 0.115 mmol/g of Pb(II), Cd(II), Cu(II) and Ni(II), respectively, according to the Langmuir model. The reaction was rapid and the kinetic experimental data were successfully modelled using the pseudo‐first order model. Quaternary biosorption experimental results revealed that severe competition exists between metal ions during the sorption onto vermiculite surface and it was inferred that the total metal uptake was distributed among four elements.
Metallo‐Deuteroporphyrin as a Biomimetic Catalyst for the Catalytic Oxidation of Lignin to Aromatics
Authors: Zhu Chenjie , Ding Weiwei , Shen Tao , Tang Chenglun , Sun Chenguo , Xu Shichao , Chen Yong , Wu Jinglan , Ying Hanjie
Published: April 2015

A series of metallo‐deuteroporphyrins derived from hemin were prepared as models of the cytochrome P450 enzyme. With the aid of the highly active CoII deuteroporphyrin complex, the catalytic oxidation system was applied for the oxidation of several lignin model compounds, and high yields of monomeric products were obtained under mild reaction conditions. It was found that the modified cobalt deuteroporphyrin that has no substituents at the meso sites but does have the disulfide linkage in the propionate side chains at the β sites exhibited much higher activity and stability than the synthetic tetraphenylporphyrin. The changes in the propionate side chains can divert the reactivity of cobalt deuteroporphyrins from the typical CC bond cleavage to CO bond cleavage. Furthermore, this novel oxidative system can convert enzymolysis lignin into depolymerized products including a significant portion of well‐defined aromatic monomers.
MnCo2O4 Nanowires Anchored on Reduced Graphene Oxide Sheets as Effective Bifunctional Catalysts for Li–O2 Battery Cathodes
Authors: Kim Jong Guk , Kim Youngmin , Noh Yuseong , Kim Won Bae
Published: April 2015

A hybrid composite system of MnCo2O4 nanowires (MCO NWs) anchored on reduced graphene oxide (RGO) nanosheets was prepared as the bifunctional catalyst of a Li–O2 battery cathode. The catalysts can be obtained from the hybridization of one‐dimensional MCO NWs and two‐dimensional RGO nanosheets. As O2‐cathode catalysts for Li–O2 cells, the MCO@RGO composites showed a high initial discharge capacity (ca. 11092.1 mAh gcarbon−1) with a high rate performance. The Li–O2 cells could run for more than 35 cycles with high reversibility under a limited specific capacity of 1000 mAh gcarbon−1 with a low potential polarization of 1.36 V, as compared with those of pure Ketjenblack and MCO NWs. The high cycling stability, low potential polarization, and rate capability suggest that the MCO@RGO composites prepared here are promising catalyst candidates for highly reversible Li–O2 battery cathodes.
Electrocatalytic Hydrogenation of 5‐Hydroxymethylfurfural in Acidic Solution
Authors: Kwon Youngkook , Birdja Yuvraj Y. , Raoufmoghaddam Saeed , Koper Marc T. M.
Published: April 2015

Electrocatalytic hydrogenation of 5‐hydroxymethylfurfural (HMF) is studied on solid metal electrodes in acidic solution (0.5 M H2SO4) by correlating voltammetry with on‐line HPLC product analysis. Three soluble products from HMF hydrogenation are distinguished: 2,5‐dihydroxymethylfuran (DHMF), 2,5‐dihydroxymethyltetrahydrofuran (DHMTHF), and 2,5‐dimethyl‐2,3‐dihydrofuran (DMDHF). Based on the dominant reaction products, the metal catalysts are divided into three groups: (1) metals mainly forming DHMF (Fe, Ni, Cu, and Pb), (2) metals forming DHMF and DMDHF depending on the applied potentials (Co, Ag, Au, Cd, Sb, and Bi), and (3) metals forming mainly DMDHF (Pd, Pt, Al, Zn, In, and Sb). Nickel and antimony are the most active catalysts for DHMF (0.95 mM cm−2 at ca. −0.35 VRHE and −20 mA cm−2) and DMDHF (0.7 mM cm−2 at −0.6 VRHE and −5 mA cm−2), respectively. The pH of the solution plays an important role in the hydrogenation of HMF: acidic condition lowers the activation energy for HMF hydro‐genation and hydrogenates the furan ring further to tetrahydrofuran.
Identification and visualization of multidimensional antigen‐specific T‐cell populations in polychromatic cytometry data
Authors: Lin Lin , Frelinger Jacob , Jiang Wenxin , Finak Greg , Seshadri Chetan , Bart Pierre‐Alexandre , Pantaleo Giuseppe , McElrath Julie , DeRosa Steve , Gottardo Raphael
Published: April 2015

An important aspect of immune monitoring for vaccine development, clinical trials, and research is the detection, measurement, and comparison of antigen‐specific T‐cells from subject samples under different conditions. Antigen‐specific T‐cells compose a very small fraction of total T‐cells. Developments in cytometry technology over the past five years have enabled the measurement of single‐cells in a multivariate and high‐throughput manner. This growth in both dimensionality and quantity of data continues to pose a challenge for effective identification and visualization of rare cell subsets, such as antigen‐specific T‐cells. Dimension reduction and feature extraction play pivotal role in both identifying and visualizing cell populations of interest in large, multi‐dimensional cytometry datasets. However, the automated identification and visualization of rare, high‐dimensional cell subsets remains challenging. Here we demonstrate how a systematic and integrated approach combining targeted feature extraction with dimension reduction can be used to identify and visualize biological differences in rare, antigen‐specific cell populations. By using OpenCyto to perform semi‐automated gating and features extraction of flow cytometry data, followed by dimensionality reduction with t‐SNE we are able to identify polyfunctional subpopulations of antigen‐specific T‐cells and visualize treatment‐specific differences between them. © 2015 The Authors. Published by Wiley Periodicals, Inc.
Flow cytometric analysis of intracellular phosphoproteins in human monocytes
Authors: Coppin Emilie , Malergue Fabrice , Thibult Marie‐Laure , Scifo Caroline , Favre Cédric , Nunès Jacques A.
Published: April 2015

Background

Using antibodies against intracellular phosphoproteins, flow cytometry can be used to monitor simultaneously multiple signaling pathways. Here, we tested a recently released procedure to analyze phosphorylation events in human monocytes upon different types of stimulation.

Methods

Whole blood was treated by lipopolysaccharide (LPS) or granulocyte‐macrophage colony‐stimulating factor (GM‐CSF), then cells were labeled by antibodies recognizing cell surface and cytosolic proteins. Human monocytes were identified by a CD14 – CD45 staining and three phosphorylated proteins such as AKT, ERK‐1/2, and STAT5, were simultaneously detected by multicolor phosphoflow analysis.

Results

By this rapid method, we are able to detect directly from a blood sample several signaling events in human monocytes where LPS stimulation induces preferentially ERK‐1/2 phosphorylation where as GM‐CSF stimulation induces STAT5 phosphorylation.

Conclusions

This procedure provides a simultaneous measurement of multiple activated signaling molecules using a simplified and rapid protocol. © 2015 International Clinical Cytometry Society
Glioblastoma multiforme with epithelial differentiation: A potential diagnostic pitfall in cerebrospinal fluid cytology
Authors: Gill Simpal K. , Padmanabhan Vijayalakshmi , Hickey William F. , Marotti Jonathan D.
Published: April 2015

Cerebrospinal fluid (CSF) cytology provides valuable diagnostic and prognostic information for diseases of the central nervous system (CNS) and remains the gold standard for the detection of neoplastic meningitis. Metastatic involvement of the CSF by non‐CNS neoplasms far surpasses that of primary brain tumors, although conventional glioblastoma multiforme (GBM) can occasionally be identified in the CSF. GBM with epithelial differentiation is an uncommon variant that may contain features such as adenoid structures, signet ring cells, or squamous metaplasia. Herein, we present a case of GBM with epithelial differentiation to highlight a potential diagnostic pitfall in CSF cytology. A 55‐year‐old man presented with neurological symptoms and a 6.4 cm left temporal lobe cystic mass. Primary resection revealed GBM with focal epithelial differentiation confirmed by cytokeratin, epithelial membrane antigen, and glial fibrillary acidic protein immunohistochemical studies. Four months following primary resection, the patient developed severe headache for which a lumbar puncture with CSF cytologic evaluation was performed. The cytospin preparation showed numerous malignant epithelioid cells with high nuclear–cytoplasmic ratio and prominent cytoplasmic vacuoles resembling metastatic carcinoma. However, the lesional cells were cytomorphologically identical to the epithelial component present in the patient's recently diagnosed GBM. This case illustrates the potential for GBM with epithelial differentiation to closely mimic metastatic carcinoma from a non‐CNS site in CSF cytology, which expands the differential diagnosis and emphasizes the necessity of clinical correlation. Diagn. Cytopathol. 2015;43:638–641. © 2015 Wiley Periodicals, Inc.
Cytologic features of the normal pineal gland of adults
Authors: Jiménez‐Heffernan José A. , Bárcena Carmen , Agra Carolina , Asunción Alfonso
Published: April 2015

It is well known that the histology of normal pineal gland may resemble not only pineal tumors but also gliomas, owing to its cellularity which is much greater than that of normal white or gray matter. Our recent experience with a case in which part of a normal gland was submitted for intraoperative consultation, together with the scarcity of cytologic descriptions, led us to perform a cyto‐histologic correlation study. In addition to the intraoperative case, we collected five pineal glands from consecutive adult autopsies. During the squash procedure, we often noted the presence of calcified grains. Smears were hypercellular, distributed in tissue fibrillary fragments and as numerous single cells, with crystalline structures. Pineal gland cells (pineocytes) were large, round, epithelioid with ill‐defined cytoplasms and moderate nuclear pleomorphism. Spindle cells with greater fibrillary quality were less common. One of the most remarkable findings seen in all cases was the presence of cytoplasmic pigment. Histological evaluation and immunohistochemical staining confirmed that the tissue was normal pineal gland. The histology showed a characteristic lobular aspect and frequent corpora arenacea. The pigment seen cytologically was also encountered in histology and corresponded to lipofuscin. Cytologic features of the pineal gland are peculiar when compared to other normal structures of the central nervous system. These features correlate closely with what is seen on histology. In an adequate clinical context, and in combination with frozen sections, cytology allows a specific recognition of the pineal gland during intraoperative pathologic consultations. Diagn. Cytopathol. 2015;43:642–645. © 2015 Wiley Periodicals, Inc.
Tin Oxometallates from the Hydrolysis of SnMe22+ in the Presence of 2,6‐Lutidine‐α2,3‐diol and Different Anions
Authors: Casas José S. , Castiñeiras Alfonso , Condori Félix , Couce María D. , Sánchez Agustín , Sordo José , Vázquez‐López Ezequiel
Published: April 2015

The reaction of the dimethyltin(IV) cation with 2,6‐lutidine‐α2,3‐diol (Lut, 2‐hydroxymethyl‐3‐hydroxy‐6‐methylpyridine) has been investigated in ethanol/water mixtures (80:20 v/v) containing Cl– and NO3–, NO3– and OAc– or Cl– and OAc– ions in various molar ratios. From these reactions, several tin oxometallates were isolated and characterized by IR, Raman, 1H NMR, 13C NMR and 119Sn NMR spectroscopy as well as ESI‐MS. The crystal structures of the compounds [Lut+H]Cl·H2O, [(SnMe2)4O2(Lut‐H)2Cl2] (1), [SnMe2(Lut‐H)Cl] (2), [(SnMe2)3O(Lut‐H)2Cl]Cl (3), [(SnMe2)3O(Lut‐H)2Cl2]·H2O (4·H2O) and [(SnMe2)4O2(Lut‐H)2(NO3)2] (5) were determined by X‐ray diffractometry. The structure of 2 contains dimeric [SnMe2(Lut‐H)Cl]2 units based on a central Sn2O2 fragment, the Lut ligand is monodeprotonated, and both the tin atoms are hexacoordinate. The other metallates are all tri‐ or tetranuclear and show the dimethyltin(IV) unit in several penta‐ or hexacoordinate environments. The C–OH group of the Lut‐H fragment, the Cl atoms, the O atoms of the nitrate group and the water molecules (for 4·H2O) are involved in hydrogen bonds, which modulate the interactions between the units and the packing in the crystal. The NMR and ESI‐MS spectra show the existence of complex equilibria in solution.
Heterocyclic Digallanates, Encapsulation of Lithium Cations in Organometallic Cages and C–H Bond Activation
Authors: Uhl Werner , Hentschel Anne , Kovert Dirk , Kösters Jutta , Layh Marcus
Published: April 2015

Hydrogallation of the dialkynylbenzenes 1,3‐(R2R′Si‐C≡C)2C6H4 (3: R = Me, R′ = Ph; 4: R = Ph, R′ = Me) with dichlorogallane, H‐GaCl2, afforded the corresponding dialkenylbenzenes 5 and 6, with GaCl2 groups geminal to the silyl substituents. Compound 6 was characterised by crystal structure determination, which revealed intramolecular bridging of both gallium atoms by two chlorine atoms as a new structural motif. Treatment of 5 and 6 with six equivalents of ethyllithium gave unprecedented heterocyclic digallanates 7 and 8, in which two four‐coordinate gallium atoms were bridged by two 1,3‐dialkenylbenzene spacer ligands. The obtained large heterocycles encapsulated two lithium counterions in their molecular cavities. The lithium atoms were coordinated in a cryptand‐like fashion and showed a variety of short contacts to aromatic rings, alkenyl groups, and α‐carbon atoms of terminal ethyl groups. They could be removed from the molecular cavity by coordination with chelating 1,2‐dimethoxyethane ligands. Heating of digallanates 7 and 8 in toluene to more than 100 °C over a period of 5 h resulted in fascinating transformations with C–H bond activation and ortho‐metallation. Five‐membered GaC4 metallacycles were formed, which had a terminal R2R′Si‐CH=CH‐ group resulting from the formal protolytic cleavage of an alkenyl–gallium bond by the ortho‐hydrogen atom.
Synthesis of Binary Sb2E3 (E = S, Se) and Ternary Sb2(S,Se)3 Nanowires Using Tailor‐Made Single‐Source Precursors
Authors: Heimann Stefan , Assenmacher Wilfried , Prymak Oleg , Schulz Stephan
Published: April 2015

Thermal decomposition of four single‐source precursors of the type (Et2Sb)2E and Et3SbE (E = S, Se) at 170 °C in the presence of suitable capping agents yielded binary Sb2S3 and Sb2Se3 nanowires. In addition, simultaneous decomposition of (Et2Sb)2S and(Et2Sb)2Se gave the ternary phase Sb2(S,Se)3 with almost equal S and Se concentrations. The materials were characterized by XRD, REM, EDX, ED and HRTEM.
A Flexible Route to Indole Scaffolds – Formal Synthesis of (±)‐Mersicarpine
Authors: Pfaffenbach Magnus , Gaich Tanja
Published: April 2015

The formal synthesis of racemic mersicarpine was accomplished in an operationally simple, reliable, and efficient manner in eight isolated steps. The use of a common intermediate increases the degree of synthetic flexibility and allows the construction of two completely different polycyclic alkaloid skeletons.
Cloud broker service‐oriented resource management model
Authors: Aazam Mohammad , Huh Eui‐Nam
Published: April 2015

With the increasing digital media content, cloud computing's importance is scaling up very fast. It provides ease of management for the growing media content. Besides this, features like ubiquitous access, service creation, service discovery and resource provisioning play a significant role. Cloud arena is going beyond this now, and the next era is of cloud federation. Services would be brought up together to the user through multiple clouds, known as cloud federation or intercloud computing. Although still in its infancy, intercloud computing is meant to provide more scalable, efficient and better managed services. Cloud broker is an important feature of intercloud computing, which plays its role in terms of resource management, service discovery, service‐level agreement negotiation and match making between service provider(s) and customer(s). The already performed studies have trivially addressed brokerage in intercloud environment, and no complete resource management model is presented so far. In this study, we present a detailed service‐oriented dynamic resource management model, which covers the issues of resource prediction, customer type‐based resource estimation and reservation, advanced reservation, pricing, refunding and acquired quality of service‐based refunding. We have implemented our system in Java/NetBeans 8.0 (Oracle Corporation) and evaluated through CloudSim 3.0.3 (The CLOUDS Lab, The University of Melbourne, Australia) toolkit, on 11 parameters. Our methodology was modelled on Google Cluster trace of 12 000 machines. The results and discussion show the validity and performance of our system. Copyright © 2015 John Wiley & Sons, Ltd.
A mesh‐adaptative metric‐based full multigrid for the Poisson problem
Authors: Brèthes Gautier , Allain Olivier , Dervieux Alain
Published: April 2015

This paper studies the combination of the full‐multigrid (FMG) algorithm with an anisotropic metric‐based mesh adaptation algorithm. For the sake of simplicity, the case of an elliptic two‐dimensional partial differential equation is studied. Meshes are unstructured and non‐embedded, defined through the metric‐based parameterization. A rather classical MG preconditioner is applied, in combination with a quasi‐Newton fixed point. An anisotropic metric‐based mesh adaptation loop is introduced inside the FMG algorithm. FMG convergence stopping test is revisited. Applications to a few two‐dimensional continuous and discontinuous coefficient elliptic model problems show the efficiency of this combination. Copyright © 2015 John Wiley & Sons, Ltd.
Board Background Heterogeneity and Exploration‐Exploitation: The Role of the Institutionally Adopted Board Model
Authors: Heyden Mariano L.M. , Oehmichen Jana , Nichting Sven , Volberda Henk W.
Published: April 2015

Boards of directors are in a position to contribute vital knowledge resources to strategy‐making. We propose that the relation between board functional background heterogeneity and exploration‐focused versus exploitation‐focused strategy is contingent on the extent to which the institutionally adopted board model enables or constrains inclusion of the board's knowledge resources in strategy‐making. We empirically juxtapose the Anglo‐Saxon (‘one‐tier’) and Rhineland (‘two‐tier’) board models in the U.K. and Germany, respectively, and find support for our assertion that the influence of board functional background heterogeneity on relative exploration orientation is more pronounced when the adopted board model accommodates inclusion of the board's knowledge resources into strategy‐making. Implications for theory and practice are discussed.
Determinants of US Prescription Drug Utilization using County Level Data
Authors: Nianogo Thierry , Okunade Albert , Fofana Demba , Chen Weiwei
Published: April 2015

Prescription drugs are the third largest component of US healthcare expenditures. The 2006 Medicare Part D and the 2010 Affordable Care Act are catalysts for further growths in utilization becuase of insurance expansion effects. This research investigating the determinants of prescription drug utilization is timely, methodologically novel, and policy relevant. Differences in population health status, access to care, socioeconomics, demographics, and variations in per capita number of scripts filled at retail pharmacies across the USA justify fitting separate econometric models to county data of the states partitioned into low, medium, and high prescription drug users. Given the skewed distribution of per capita number of filled prescriptions (response variable), we fit the variance stabilizing Box–Cox power transformation regression models to 2011 county level data for investigating the correlates of prescription drug utilization separately for low, medium, and high utilization states. Maximum likelihood regression parameter estimates, including the optimal Box–Coxλpower transformations, differ across high (λ = 0.214), medium (λ = 0.942), and low (λ = 0.302) prescription drug utilization models. The estimated income elasticities of −0.634, 0.031, and −0.532 in high, medium, and low utilization models suggest that the economic behavior of prescriptions is not invariant across different utilization levels. Copyright © 2015 John Wiley & Sons, Ltd.
Interleukin‐1α and brain inflammation
Authors: Brough David , Denes Adam
Published: April 2015

Acute brain injuries such as caused by stroke are amongst the leading causes of death and are the leading cause of disability. Despite this there are very limited therapeutic options, and new therapeutic strategies and targets are required. Inflammation is known to exacerbate brain injury and is now considered as a potential therapeutic target. The damaging inflammation that occurs after acute brain injury is driven by pro‐inflammatory members of the interleukin (IL)−1 cytokine family, namely, IL‐1α and IL‐1β. Previous research efforts have focussed on the biology and contribution of IL‐1β. However, we now recognise that IL‐1α is an early and important mediator of inflammation after injury. This review focuses on what is known about IL‐1α, its regulation and its contribution to brain injury. Inhibiting mechanisms regulating the processing and release of IL‐1α may offer new therapeutic targets for the treatment of devastating acute brain injuries. © 2015 IUBMB Life, 2015 67(5):323–330, 2015
N‐Benzylcinnamide induces apoptosis in HPV16 and HPV18 cervical cancer cells via suppression of E6 and E7 protein expression
Authors: Xiong Yuanhuan , Chen Lin , Luo Puying
Published: April 2015

Seventy percent of all cervical cancers are caused by human papillomavirus (HPV) infections. Natural products are being extensively explored for their potential ability to prevent and treat cervical cancers. N‐benzylcinnamide (PT‐3) is a natural product purified from Piper submultinerve. Whether or not PT‐3 has an effect on cervical cancer cells is as yet unknown. Therefore, we set out to explore the mechanism of action behind PT‐3 and how it affects cells that either contain or lack HPV DNA. Our results demonstrate that PT‐3 slows the growth kinetics of CaSki (HPV‐16 positive) and HeLa (HPV‐18 positive) cells in a dose‐dependent manner, but does not slows HPV‐negative cells. Importantly, we also found that PT‐3 induces apoptosis by suppressing expression of E6 and E7 viral oncogenes in HPV‐infected cervical cancer CaSki and HeLa cells. Moreover, we found that suppression of E6 and E7 expression leads to modulations in p53 and protein retinoblastomas, which are not changed in HPV‐negative cervical cancer C33A cells. These findings demonstrate that PT‐3 can effectively promote apoptosis by downregulating expression of E6 and E7. © 2015 IUBMB Life, 2015 67(5):374–379, 2015