bluuebunny/crossref_metadata_2025 huggingface dataset:
CID12261165, a flavonoid compound as antibacterial agents against quinolone-resistant Staphylococcus aureus
Authors: Morimoto Yuh , Aiba Yoshifumi , Miyanaga Kazuhiko , Hishinuma Tomomi , Cui Longzhu , Baba Tadashi , Hiramatsu Keiichi
Published: January 2023

Flavonoids are plant-produced secondary metabolites that are found ubiquitously. We have previously reported that apigenin, a class of flavonoid, has unique antimicrobial activity against Staphylococcus aureus (S. aureus), one of the major human pathogens. Apigenin inhibited fluoroquinolone-resistant S. aureus with DNA gyrase harboring the quinolone-resistant S84L mutation but did not inhibit wild-type DNA gyrase. In this study, we describe five flavonoids, quercetin, luteolin, kaempferol, baicalein, and commercially available CID12261165, that show similar antimicrobial activity against fluoroquinolone-resistant S. aureus. Among them, CID12261165 was the most effective with MIC values of ≤ 4 mg/L against quinolone-resistant S. aureus strains. In vitro DNA cleavage and supercoiling assays demonstrated inhibitory activity of CID12261165 against mutated DNA gyrase, whereas activity against wild-type DNA gyrase was not observed. CID12261165 also inhibited quinolone-resistant Enterococci with an MIC value of 8 mg/L. While fluoroquinolone-resistant amino acid replacements can improve the fitness of bacterial cells, it is unknown why quinolone-susceptible S. aureus strains were predominant before the introduction of fluoroquinolone. The present study discusses the current discrepancies in the interpretation of antimicrobial activities of flavonoids, as well as the possible reasons for the preservation of wild-type DNA gyrase wherein the environmental flavonoids cannot be ignored.
Prognostic effect of albumin-to-alkaline phosphatase ratio on patients with hepatocellular carcinoma: a systematic review and meta-analysis
Authors: Zhang Xinyuan , Xin Yujing , Chen Yi , Zhou Xiang
Published: January 2023

The prognostic value of albumin-to-alkaline phosphatase ratio (AAPR) in patients with hepatocellular carcinoma (HCC) remains controversial. This meta-analysis aims to evaluate the prognostic role of AAPR in patients with HCC. The databases of Web of Science, Embase, Cochrane Library and PubMed were comprehensively searched from inception to April 25, 2022. Pooled hazard ratio (HR) and 95% confidence interval (CI) were calculated with Stata 16.0 software for the assessment of the relationship between AAPR and overall survival (OS) as well as recurrence-free survival (RFS) in patients with HCC. A total of 2634 patients from 12 cohorts were included in this meta-analysis. The pooled results showed that lower AAPR predicted poorer OS (HR 2.02, 95% CI 1.78–2.30). Similarly, pooled results demonstrated that lower AAPR also predicted poorer RFS (HR 1.88, 95% CI 1.37–2.57). The heterogeneity for RFS by multivariate analytic results and the publication bias for OS existed, however, the subgroup analysis, meta-regression analysis as well as adjustment using trim-and-fill analysis confirmed an association between AAPR and OS as well as RFS. This meta-analysis proves that lower AAPR in patients with HCC predicted inferior survival outcomes, and AAPR might be a promising indicator for the prognosis of HCC.
Stage distinctive communication networks of the online breast cancer community
Authors: Jo Wonkwang , Jang Sou Hyun , Shin Eun Kyong
Published: January 2023

In this study, we reveal the distinctive communication network structures and contents of online breast cancer community posts in accordance with different cancer stages. Using data collected from community.breastcancer.org, a major online breast cancer community (28,139 original posts and 663,748 replies), we traced the communication network structures and contents of replies associated with its severity. By combining network and quantitative content analyses, we deciphered the functions and utilities of health-related online communication. We found an inverse relationship between offline epidemiological prevalence and online communication activation. Despite the relatively small percentage of breast cancer patients, it was found that the more severe the condition of breast cancer, the more active online communication was. We further found that as pathological severity advances, communication networks move from informational exchange to emotional support. The capture of online social networks based on the cancer stage can help unpack the distinctive communication patterns found across different cancer severities. Our results provide insights into a possible online communication intervention design tailored to symptom severity.
The microstructure and mechanical properties of microwave-heated lunar simulants at different input powers under vacuum
Authors: Lim Sungwoo , Degli-Alessandrini Giulia , Bowen James , Anand Mahesh , Cowley Aidan
Published: January 2023

To achieve a sustainable human presence on the Moon, it is critical to develop technologies utilising the local resources (a.k.a. in-situ resource utilisation or ISRU) for construction and resource extraction. In this study, we investigate the viability of microwave heating of two lunar soil simulants (JSC-1A and OPRH3N) under vacuum conditions, to simulate a lunar surface environment compared to previous studies performed at atmospheric pressure. All simulants are thermally treated in a bespoke 2.45 GHz microwave apparatus using three input powers: 1000 W, 600 W and 250 W. The microstructures and mechanical properties of the microwaved samples are analysed to identify their potential applications. Our key findings are: (i) higher input powers generate materials in shorter fabrication times with higher mechanical strengths and higher yields despite the same total energy input; (ii) the microstructures of the microwaved samples under vacuum are very different from those under atmospheric conditions due to the widespread vesicles/bubbles; and (iii) different heating rates caused by different input powers can be utilised for specific ISRU purposes: higher input powers for extra-terrestrial construction and lower input powers for resource extraction. Findings from this study have significant implications for developing a microwave-heating payload for lunar ISRU demonstration missions.
Can Apple and Google continue as health app gatekeepers as well as distributors and developers?
Authors: Sadare Olamide , Melvin Tom , Harvey Hugh , Vollebregt Erik , Gilbert Stephen
Published: January 2023

Mobile apps are the primary means by which consumers access digital health and wellness software, with delivery dominated by the ‘Apple App Store’ and the ‘Google Play Store’. Through these virtual storefronts Apple and Google act as the distributor (and sometimes, importer) of many thousands of health and wellness apps into the EU, some of which have a medical purpose. As a result of changes to EU law which came into effect in May 2021, they must now ensure that apps are compliant with medical devices regulation and to inform authorities of serious incidents arising from their use. The extent to which these new rules are being complied with in practice is uneven, and in some areas unclear. In light of EU legislation related to competition, which came into effect in November 2022, it is also unclear how conflicts of interest can be managed between Apple and Google’s roles as gateway duopoly importers and distributors whilst also developers of their own competitive health products. Finally, with the proposed European health data space regulation, wellness apps will be voluntarily registered and labelled in a fashion more like medical devices than consumer software. We explore the implications of these new regulations and propose future models that could resolve the apparent conflicts. All stakeholders would benefit from improved app store models to sustainably evolve safer, better, and fairer provision of digital health applications in the EU. As EU legislation comes into force it could serve as a template for other regions globally.
A NIR fluorescent probe for the detection of renal damage based on overrepresentation of alanine aminopeptidase enzyme
Authors: Domínguez Marcia , Meyer Kathleen , Sancenón Félix , Blandez Juan F. , Serrano Manuel , Martínez-Máñez Ramón
Published: January 2023

Here, we describe the design of a molecular probe (NB-ALA) based on the Nile Blue fluorophore, which can detect alanine aminopeptidase enzyme (a kidney damage biomarker) in urine by simple fluorometric measurements.
Introducing carbohydrate patterning in mannose-decorated supramolecular assemblies and hydrogels
Authors: Rijns Laura , Su Lu , Maxeiner Konrad , Morgese Giulia , Ng David Y. W. , Weil Tanja , Dankers Patricia Y. W.
Published: January 2023

Mannose patterning is introduced into benzene-1,3,5-tricarboxamide (BTA)-based supramolecular assemblies through copolymerization of fully mannosylated M3 BTA with non-functionalized nBTA, and compared to their asymmetric homopolymer counterparts (M1 and M2 BTA).
Ag-doped InP/ZnS quantum dots for type-I photosensitizers
Authors: Ren Can , Hu Die , Cui Yanyan , Chen Peixian , Xu Xiaoqian , Cheng Jiaji , He Tingchao
Published: January 2023

Ag-doping can efficiently enhance the multiphoton absorption and type-I photodynamic therapy efficiency of InP-based quantum dots.
Squaryl group-modified UDP analogs as inhibitors of the endoplasmic reticulum-resident folding sensor enzyme UGGT
Authors: Abe Junpei , Takeda Yoichi , Kikuma Takashi , Kizuka Yasuhiko , Kajiura Hiroyuki , Kajihara Yasuhiro , Ito Yukishige
Published: January 2023

UDP-Glc:glycoprotein glucosyltransferase (UGGT) has a central role to retain quality control of correctly folded N-glycoprotein in the endoplasmic reticulum (ER).
Synthesis and characterization of a new isoxazolone-based nonlinear optical crystal: MPMOI
Authors: Yang Ying , Zhao Jianjuan , Zhang Xinyuan , Hu Zhanggui , Wu Yicheng
Published: January 2023

A new acentric isoxazolone-based crystal MPMOI (C18H15NO4,P212121) was designed and synthesized, exhibiting a second harmonic generation response 3.7 times larger than that of KDP.
Substituted benzoate-anchored decanuclear titanium-oxo clusters featuring an unprecedented defective double-cubane geometry
Authors: Pei Xin-Yue , He Ying , Wang Jia-Yin , Wang Hong-Yan , Bo Qi-Bing
Published: January 2023

Four substituted benzoate-anchored decanuclear TOCs featuring an unprecedented defective double-cubane geometry are solvothermally synthesized with high yield based on DMF solvent.
An extensive assessment of the performance of pairwise and many-body interaction potentials in reproducing ab initio benchmark binding energies for water clusters n = 2–25
Authors: Herman Kristina M. , Xantheas Sotiris S.
Published: January 2023

We assess the performance of 7 pairwise additive and 8 families of many-body potentials in reproducing high-level ab initio benchmark values for the binding energy and the many-body expansion (MBE) of water clusters n = 2–11, 16–17, 20, 25.
Investigation of thermal control in phase-changing ABO3 perovskites via first-principles predictions: general mechanism of emittance
Authors: Tong Liping , Xu Nianao , Li Hongchao , Yang Lan , Wang Zhongyang , Guo Qixin , Fan Tongxiang
Published: January 2023

The general mechanism of emittance variation is proposed using first-principles prediction in 76 kinds of phase-changing ABO3 perovskites, and the connections of emittance variation with bandgap difference and volume-distortion rate are described.
Vibrational spectroscopy of Cu+(H2)4: about anharmonicity and fluxionality
Authors: Jin Jiaye , Wulf Toshiki , Jorewitz Marcel , Heine Thomas , Asmis Knut R.
Published: January 2023

The vibrational spectra of the copper(i) cation–dihydrogen complexes Cu+(H2)4, Cu+(D2)4 and Cu+(D2)3H2 are studied using cryogenic ion trap vibrational spectroscopy in combination with quantum chemical calculations.
Identifying water blending areas and associated iron release risk by analyzing sulfate and strontium concentration difference in a metropolitan drinking water distribution system
Authors: Pan Linlin , Li Guiwei , He Yitian , Chen Ruya , Zhang Yao , Shi Baoyou
Published: January 2023

Identifying water blending areas by analyzing sulfate and strontium concentration difference in a metropolitan drinking water distribution system.
Wood-inspired high-efficiency bioreactors with hierarchical porous structures for continuous flow reactions
Authors: Shen Yu-Shi , Zhou Xing , You Shuai , Gong Lu-Chan , Wang Jun , Chen Tao , Zhao Wei-Guo , Yao Xiao-Hui , Zhang Dong-Yang
Published: January 2023

A porous cellulose bioreactor with directional channels was prepared for flow catalysis. The hierarchical porous structure enhanced the mass transfer and improved the catalytic efficiency.
Optimisation of the electrochemical conversion of CO2 into formate in a flow cell configuration using a bismuth-based electrocatalyst
Authors: Miola Matteo , Chillé Donatella , Papanikolaou Georgia , Lanzafame Paola , Pescarmona Paolo P.
Published: January 2023

In the context of the electrochemical conversion of CO2 into valuable products, it is of crucial importance to optimise the electrochemical cell parameters towards industrially-relevant activity, selectivity and stability of the electrocatalyst.
M-subshell X-ray production cross sections of Re and Os by electron impact
Authors: Aguilar Alfredo , Castellano Gustavo , Segui Silvina , Trincavelli Jorge , Carreras Alejo
Published: January 2023

X-ray production cross sections of Re and Os M subshells were measured using an electron beam.
Oligoaniline-assisted self-assembly of polyaniline crystals
Authors: Hill Ian M. , Wu Di , Xu Bohao , Wang Yue
Published: January 2023

The presence of a small amount of oligomer can induce ordering and crystallization of the parent conducting polymer, resulting in highly conductive, compositionally homogeneous crystals with defined molecular weights.
Superior thermoelectric properties through triangular triple quantum dots (TTQD) attached to one metallic and one superconducting lead
Authors: Yao Hui , Cheng Cai-Ping , Li Li-Li , Guo Rui , Guo Yong , Zhang Chao
Published: January 2023

We theoretically investigate the properties of the N-TTQD-S system: thermoelectric coefficients strongly depend on the ratio of superconducting gap to interdot coupling, as well as asymmetry and interference effects.
A new mononuclear Fe(iii) Mannich-base complex with selective histidine binding and catechol oxidase activity
Authors: Mandal Bikramaditya , Haldar Anwesha , Ganguly Rakesh , Saha Rajat , Mandal Debdas
Published: January 2023

The design of amino acid sensors have significant applications in biomarkers.
Synthesis and mesomorphic characterization of novel amphotropic steroidal esters
Authors: Bhat S Vanishree , Swamynathan K. , Raghunathan V. A. , Kumar Sandeep
Published: January 2023

Amphiphilic steroidal esters as novel mesogens displaying cholesteric, polymorphic smectic, TGB and blue phases.
Determination of the acidic structure and Lewis activity in an Fe-based ionic liquid with slope analysis of the quantitative pyridine-IR spectrum
Authors: Liu Fen , Bai Wenxuan , Gu Zhiping , Zhang Jingcong , Chen Jinxiang , Yu Jiang
Published: January 2023

Protonation, Fe2+ and solvent can induce different acidic structures and Lewis activity of Fe-IL by analyzing the slope of IA(X) ∼ n(Py).
Ultra-high-resolution greyscale fluorescence images via UV-exposure of thin flexible phosphor films
Authors: Riesen Nicolas , Priest Craig , Lancaster David G. , Badek Kate , Riesen Hans
Published: January 2023

High resolution greyscale fluorescence images created in thin phosphor films using UV light.
Oxygenated copper vanadium selenide composite nanostructures as a cathode material for zinc-ion batteries with high stability up to 10 000 cycles
Authors: Narsimulu D. , Krishna B. N. Vamsi , Shanthappa R. , Yu Jae Su
Published: January 2023

The oxygenated copper vanadium selenide composite electrode material as a cathode for aqueous zinc-ion batteries exhibits high capacity with ultra-long cycling life.
Investigating the interfacial properties of halide perovskite/TiOx heterostructures for versatile photocatalytic reactions under sunlight
Authors: Kim Tae Hyung , Park Inho , Lee Kyeong Ho , Sim Jin-Han , Park Min-Ho , Han Tae-Hee , Paik Ungyu , Jang Jaeyoung , Park Ho Bum , Kim Young-Hoon
Published: January 2023

Heterostructures of metal halide perovskites and TiOx are efficient photocatalytic materials owing to the combination of the high absorption coefficients and long charge-carrier lifetimes of perovskites, and efficient photocatalytic activity of TiOx.
Single-site bipyridine cobalt complexes covalently embedded into graphitic carbon nitride with excellent photocatalytic activity and selectivity towards CO2 reduction
Authors: Wei Jiajia , Chen Xing , Liu Chenying , Zhou Qian , Tian Shufang , Wang Ke-Fan , Lu Minghua
Published: January 2023

2, 2’-bpy-5, 5’-dialdehyde copolymerized with urea to fulfill 2, 2’-bpy imbedded into the skeleton of g-CN and then chelated with Co2+ to fabricate the single-site photocatalyst g-CN-bpy-Co with excellent catalytic performance towards CO2 reduction.
Steering CO2electroreduction selectivity towards CH4and C2H4on a tannic acid-modified Cu electrode
Authors: Xu Keqiang , Li Jinhan , Liu Fangming , Xu Wence , Zhao Tete , Cheng Fangyi
Published: January 2023

The selectivity of C2H4and CH4in CO2electroreduction can be modulated on a Cu electrode by tannic acid modification, which jointly promotes H2O dissociation and stabilizes the intermediate.
Prediction of the enantiomeric excess value for asymmetric transfer hydrogenation based on machine learning
Authors: Gao Ben , Chang Yuqi , Tang Wenjun
Published: January 2023

By combining the sterimol parameters and burial volume with the molecular descriptors calculated by quantum chemistry, the enantioselectivity of asymmetric transfer hydrogenation can be predicted.
Palladium-catalyzed four-component cascade carbonylative cyclization to access carbonyl-bridged bisheterocycles
Authors: Song Yufei , Wei Guangming , Quan Zhaolin , Chen Zhengkai , Wu Xiao-Feng
Published: January 2023

We developed a palladium-catalyzed four-component carbonylative cyclization of alkenyl-tethered aryl iodides, trifluoroacetimidoyl chlorides and propargyl amines for the construction of carbonyl-bridged bisheterocycles.
Highly efficient construction of 2,3-disubstituted indoline derivatives by [4 + 1] annulation of sulfur ylides and o-sulfonamido aldimines
Authors: Xu Mengjiao , You Mengwei , Su Yang , Lu Boxue Ruan , Liu Ling , Lv Xin , Wang Shoulei , Mao Hui , Zhou Liejin
Published: January 2023

A highly efficient [4 + 1] annulation of sulfur ylide salts and o-sulfonamido aldimines for construction of valuable 2,3-disubstituted indolines is reported. It is worth noting that indoles could also be synthesized by this cascade reaction.
Catalyst-free visible-light-induced decarbonylative C–H alkylation of quinoxalin-2(1H)-ones
Authors: Shi Xiaodi , Cao Yunpeng , Liu Yuxiu , Niu Kaikai , Song Hongjian , Zhang Jingjing , Wang Qingmin
Published: January 2023

Direct functionalization of C(sp3)–H bonds is an effective, straightforward method for accessing a diverse array of heteroarene derivatives.
Versatile carbon superstructures for energy storage
Authors: Song Ziyang , Miao Ling , Lv Yaokang , Gan Lihua , Liu Mingxian
Published: January 2023

The design strategies and underlying mechanisms of versatile carbon superstructures for energy storage are reviewed. Current challenges and development roadmaps are proposed to spur the further exploration of carbon superstructures.
LHRH conjugated gold nanoparticles assisted efficient ovarian cancer targeting evaluated via spectral photon-counting CT imaging: a proof-of-concept research
Authors: Kumar Dhiraj , Moghiseh Mahdieh , Chitcholtan Kenny , Mutreja Isha , Lowe Chiara , Kaushik Ajeet , Butler Anthony , Sykes Peter , Anderson Nigel , Raja Aamir
Published: January 2023

Emerging multifunctional nanoparticulate formulations take advantage of nano-meter scale size and surface chemistry to work as a therapeutic delivery agent and a diagnostic tool for non-invasive real-time monitoring using SPCCT imaging technology.
Electrospun fibrous membrane reinforced hydrogels with preferable mechanical and tribological performance as cartilage substitutes
Authors: Chen Qin , Yan Xiaodong , Chen Kai , Feng Cunao , Wang Dagang , Li Xiaowei , Zhao Xiaoduo , Chai Zhimin , Wang Qingliang , Zhang Dekun , Zeng Hongbo
Published: January 2023

The mechanical properties of PPG-4 hydrogel were comparable to natural cartilage. The friction coefficient of PPG-4 hydrogel is low as 0.039. The PPG-4 hydrogel could be widely used in tissue engineering such as cartilage replacement.
Biodegradable polyurethane-incorporating decellularized spinal cord matrix scaffolds enhance Schwann cell reprogramming to promote peripheral nerve repair
Authors: Wang Yanchao , Lin Jingjing , Chen Jinlin , Liang Ruichao , Zhang Qiao , Li Jiehua , Shi Min , Li Lei , He Xueling , Lan Ting , Hui Xuhui , Tan Hong
Published: January 2023

Decellularized extracellular matrix (dECM) incorporating polyurethane nerve guide conduits (NGCs) are a promising strategy to replace autogenous nerve grafting for the treatment of peripheral nerve system (PNS) injury.
Transient imine as a directing group for the Pd-catalyzed anomeric C(sp3)–H arylation of 3-aminosugars
Authors: Ghouilem Juba , Bazzi Sokna , Grimblat Nicolas , Retailleau Pascal , Gandon Vincent , Messaoudi Samir
Published: January 2023

The first example of Pd(ii)-catalyzed anomeric C(sp3)–H arylation of 3-aminosugars by using a transient directing group approach is reported. The free amine was then exploited in a CuAAC reaction to access to a variety of C3-triazoloC-glycosides in good yields.
Preparation of pure active water for auto-catalytic reactions performed in it
Authors: Yu Shih-Hao , Yang Chih-Ping , Mai Fu-Der , Tsai Hui-Yen , Liu Yu-Chuan
Published: January 2023

Schematic shows the preparation of pure active water.
Tumor-Fatigue-Sprechstunde der Bayerischen Krebsgesellschaft e.V.:
Studienprotokoll einer Beobachtungsstudie zur flächendeckenden
Versorgungsstruktur in Bayern
Authors: Müller Karolina , Fischer Irene , Koller Michael , Besseler Markus
Published: January 2023

Tumor-assoziierte Fatigue (TF) ist ein sehr belastender Zustand von anhaltender
Müdigkeit, Schwäche und Energiemangel auf körperlicher,
affektiver und kognitiver Ebene. TF tritt im Kontext einer Tumorerkrankung
und/oder ihrer Therapie auf und geht mit Einschränkungen von
Alltagsfunktionalität, Lebensqualität und Überlebenszeit
einher. Bisher mangelt es in Deutschland an Einrichtungen, die sich auf die
Identifikation therapierbarer Einflussfaktoren der TF sowie der Empfehlung
angemessener, evidenzbasierter Therapien spezialisiert haben. Die Bayerische
Krebsgesellschaft e.V. (BKG) hat seit 2013 mit insgesamt zehn Anlaufstellen eine
flächendeckende Versorgung in Bayern aufgebaut und bietet im Rahmen
ihrer Sprechstunde für Krebspatienten mit TF fundierte Diagnostik sowie
Beratung an. Bei der Konzeption und der Weiterentwicklung der Sprechstunde
wurden die jeweils gültigen Leitlinien berücksichtigt. Die
Sprechstunden werden von onkologisch und psychoonkologisch erfahrenen
Ärzten durchgeführt, die hinsichtlich TF geschult sind. Ziel
dieser prospektiven, multizentrischen Beobachtungsstudie ist es, den Ist-Zustand
der TF-Sprechstunde der BKG zu evaluieren. Dazu gehören die Analyse des
Angebots und Bedarfs der TF-Sprechstunde, die patientenberichtete TF vor der
TF-Sprechstunde und zehn Wochen danach, die Umsetzung empfohlener, gemeinsam
konsentierter Maßnahmen zur Reduktion der TF sowie die Analyse der
Stärken und des Verbesserungspotentials des gegenwärtigen
Systems. Die gewonnenen Ergebnisse sollen eine Übertragung auf eine
deutschlandweite Versorgung ermöglichen.
Status der stationären Behandlung psychisch erkrankter
Strafgefangener in allgemeinpsychiatrischen Abteilungen und
Kliniken
Authors: Grubbe Felix , Wagner Elias , Pogarell Oliver , Dudeck Manuela , Hasan Alkomiet
Published: January 2023

Hintergrund Stationär-psychiatrische Behandlungen von
Strafgefangenen sind in Deutschland je nach Bundesland und Justizvollzugsanstalt
unterschiedlich organisiert. Es gibt wenig Befunde bezüglich der
verschiedenen Möglichkeiten der Behandlung und der Sichtweise der
Kliniken zu dieser Thematik.

Ziel der Arbeit Ziel ist es, ein aktuelles Bild von der
Versorgungssituation bezüglich stationärer Behandlungen von
Strafgefangenen in der Allgemeinpsychiatrie und den damit verbundenen
Herausforderungen zu gewinnen.

Methodik Wir führten eine anonyme online-Befragung
bezüglich der Häufigkeit, des Umfanges und der Herausforderungen
bei der stationären Behandlung von Strafgefangenen durch. Zu dieser
Befragung wurden ca. 460 Chefärzt*innen deutscher
allgemeinpsychiatrischer Kliniken eingeladen. Neben deskriptiven Statistiken
berechneten wir Gruppen-Unterschiede nach Klinikart und nach subjektiver
Zuständigkeit für die stationäre Versorgung von
Strafgefangenen.

Ergebnisse Insgesamt nahmen 74 Chefärzt*innen teil.
51,4% der befragten Kliniken führten 2020
stationär-psychiatrische Behandlungen bei Strafgefangenen durch.
Gruppenunterschiede zwischen den Klinikarten fanden sich nur für das
Vorliegen von antizipierten Ängsten bei Mitpatient*innen.
Zwischen zuständigen und nicht zuständigen Kliniken fanden sich
diverse Unterschiede vor allem bezüglich organisatorischer Aspekte.

Diskussion Für die Behandlung von psychisch erkrankten
Strafgefangenen wurden sowohl organisatorische Hürden, als auch
Ängste bei Klinikpersonal und Mitpatient*innen durch die
Teilnehmenden genannt. Die Art der Klinik spielt hierbei eine untergeordnete
Rolle, entscheidender scheint die Zuständigkeit der Klinik für
die stationäre Versorgung psychisch erkrankter Strafgefangener zu
sein.
Pharmacological Potential of cis-jasmone in Adult Zebrafish (Danio rerio)
Authors: Bezerra Francisca Magnólia Diógenes Holanda , Vieira-Neto Antônio Eufrásio , Benevides Samara Casemiro , Tavares Kaio César Simiano , Ribeiro Antonia Deyse de Castro , Santos Sacha Aubrey Alves Rodrigues , Leite Gerlânia de Oliveira , Alves Magalhães Francisco Ernani , Campos Adriana Rolim
Published: January 2023

This study evaluates the pharmacological potential of cis-jasmone (CJ) in adult zebrafish (Danio rerio; aZF). Initially, aZF (n = 6/group) were pretreated (20 µL;
p. o.) with CJ (0.1 or 0.3 or 1.0 mg/mL) or vehicle (0.5% Tween 80). The animals were submitted to acute toxicity and locomotion tests, pentylenetetrazole-induced seizure,
carrageenan-induced abdominal edema, and cinnamaldehyde-, capsaicin-, menthol-, glutamate-, and acid saline-induced orofacial nociception. The possible mechanisms of anticonvulsant,
anxiolytic, and antinociceptive action were evaluated. The involvement of central afferent fibers sensitive to cinnamaldehyde and capsaicin and the effect of CJ on the relative gene
expression of TRPA1 and TRPV1 in the brain of aZF were also analyzed, in addition to the study of molecular docking between CJ and TRPA1, TRPV1 channels, and GABAA receptors. CJ
did not alter the locomotor behavior and showed pharmacological potential in all tested models with no toxicity. The anticonvulsant effect of CJ was prevented by flumazenil (GABAergic
antagonist). The anxiolytic-like effect of CJ was prevented by flumazenil and serotonergic antagonists. The antinociceptive effect was prevented by TRPA1 and TRPV1 antagonists. Chemical
ablation with capsaicin and cinnamaldehyde prevented the orofacial antinociceptive effect of CJ. Molecular docking studies indicate that CJ interacted with TRPA1, TRPV1, and GABAA
receptors. CJ inhibited the relative gene expression of TRPA1 and TRPV1. CJ has pharmacological potential for the treatment of seizures, anxiety, inflammation, and acute orofacial
nociception. These effects are obtained by modulating the GABAergic and serotonergic systems, as well as the TRPs and ASIC channels.
Akzeptanz der Teledermatologie: Ergebnisse einer Befragung
sächsischer Haus- und HautärztInnen
Authors: Kriwy Peter , Nötzold Anett , Seitz Anna-Theresa , Berger Roger
Published: January 2023

Ziel der Studie Mit der Befragung sächsischer Haus- und
HautärztInnen wird die Akzeptanz bzw. Nutzungsabsicht einer
teledermatologischen Anwendung untersucht. Vor dem Hintergrund der
demographischen Entwicklung in Sachsen und der geringen regionalen
FachärztInnendichte ist dieses Bundesland zur Durchführung einer
solchen Befragung besonders gut geeignet.

Methodik Auf der Grundlage einer geschichteten Zufallsauswahl wurden 108
sächsische ÄrztInnen schriftlich postalisch bzw. online befragt
(60 HausärztInnen und 48 HautärztInnen, Teilnahmequote 23,5
Prozent). Die Theorie der Akzeptanz und Nutzung von Technologie (UTAUT-Modell)
wurde auf die Teledermatologie angewendet. Vier zentrale Hypothesen wurden
abgeleitet und mit logistischen Regressionen getestet.

Ergebnisse Die getesteten Hypothesen, die Zusammenhänge zwischen
Leistungserwartung, Aufwandserwartung, sozialem Einfluss und erleichternden
Rahmenbedingungen und der Nutzungsabsicht der Teledermatologie postulieren,
werden zum Teil bestätigt. Zudem zeigt sich für Teledermatologie
ein Potential bei sächsischen HausärztInnen, da 9,5%
ihrer PatientInnen wegen Hauterkrankungen in die Praxis kommen. 78% der
HausärztInnen bieten Hautkrebsscreenings an.

Schlussfolgerung Die Bevölkerungsstruktur und die geringe
Arztdichte in Sachsen wären günstige Voraussetzungen zur
Implementation der Teledermatologie. Tiefergehende Bedenken der Haus- und
HautärztInnen gegenüber der Teledermatologie konnten aufgrund
der Befragungsergebnisse nicht festgestellt werden.
Inanspruchnahme einer Spezialsprechstunde für psychisch
kranke Eltern
Authors: Brandl Eva Janina , Reiche Susanne , Hullmeine Lisa , Mick Inge , Hadzibegovic Jasmina , Zerbe Lena-Karoline , Bermpohl Felix , Schouler-Ocak Meryam
Published: January 2023

Hintergrund Eltern mit psychischen Erkrankungen haben in der Peripartalzeit
einen großen Unterstützungsbedarf. Bislang gibt es nur wenige
spezialisierte Angebote. In dieser Untersuchung wird eine Spezialsprechstunde
für psychisch kranke Eltern ausgewertet.

Methoden Es wurden demographische und krankheitsbezogene Daten der
Patient*innen der Elternsprechstunde in der Psychiatrischen
Universitätsklinik der Charité im St. Hedwig Krankenhaus
(N=279) aus dem Zeitraum 06/2017 bis 12/2021
ausgewertet.

Ergebnisse Die Sprechstunde wurde vor allem von Personen mit affektiven
Störungen, hohem Bildungsgrad und guter Therapieadhärenz in
Anspruch genommen. Personen mit Migrationshintergrund erhielten seltener eine
ambulante Psychotherapie.

Diskussion Die Daten zeigen eine hohe Inanspruchnahme des ambulanten
Angebots, jedoch eher durch eine Population mit höherem
sozioökonomischem Status. Aufgrund der klinischen Relevanz wäre
ein Ausbau von Angeboten für Eltern wünschenswert.
Synthesis of the CDF Ring System of Hexacyclinic Acid
Authors: Prunet Joëlle , Audic Alexandre
Published: January 2023

Diverse approaches to prepare the nine-membered ring precursor of the DEF fragment of hexacyclinic acid are described, culminating in the synthesis of the CDF ring system of this natural product. The key steps are a Michael addition/elimination sequence and an original intramolecular Tsuji–Trost reaction of an enol with an allylic alcohol.
Uterine Scar Evaluation during the Postpartum: Pleading for Extradecidual Suturing during Cesarean Section
Authors: Kesrouani Assaad K. , Abdelkhalek Yara , Abdallah Wael , Chaccour Christian , Hatoum Inaam , Richa Freda
Published: January 2023

Objective Our objective is to evaluate ultrasound differences in uterine scar between techniques using extramucosal suturing and full thickness suturing of the uterine incision.

Study Design A retrospective observational study included cases of primary cesarean section. At 6-week postpartum, we evaluated by endovaginal ultrasound two elements in the sagittal view: the thickness of the uterine scar and the surface of defect (niche). Hysterotomy sites closed using a running full-thickness technique including the uterine mucosa (group 1) were compared to hysterotomies operated by the same surgeon but with extramucosal suturing (group 2). The operator switched from the running suture technique to extramucosal in 2013.

Results The study included 241 patients (115 cases in group 1 that were compared to 126 cases in group 2). There were no significant differences in age or body mass index between the two groups. Cesarean scar and niche were detectable in the entire studied population. There was a significant difference in both uterine scar thickness (5.8 vs. 6.2 mm, p = 0.02) and the presence and size of the niche (49 vs. 40 mm2, p = 0.001) in transvaginal ultrasound performed at 6-week postpartum.

Conclusion Extramucosal suturing of the uterine scar seems to be associated with a better outcome on the postpartum ultrasound evaluation.

Key Points
Indian Perspective of Burnout Among Plastic Surgeons
Authors: Karanjkar Ankur , Panse Nikhil , Panse Smita , Sahasrabudhe Parag
Published: January 2023

Introduction Over the last decade, the term “Burnout” has become familiar term in all walks of life, particularly medicine. Emotional exhaustion, depersonalization, and a low sense of personal accomplishment make up the triad. At least a third of plastic surgeons are having burnout according to the western literature. Data on burnout in Indian plastic surgeons is lacking. We have made an attempt to analyze the incidence and factors responsible for burnout among plastic surgeons in India.

Materials and Methods An online survey was conducted in India to assess burnout among plastic surgeons from June to November 2019. Consent, demographic information, stress-related factors, the abbreviated Maslach Burnout Inventory (aMBI), and Satisfaction with Medicine were all included section wise in the survey. Both used scales were validated. Data were gathered using Google forms, then uploaded to an Excel file and analyzed. A multivariable and univariable analysis of factors associated with burnout was carried out.

Results Twenty-two percent of 330 plastic surgeons who responded were assessed to have moderate to high emotional exhaustion, 5% had moderate to high depersonalization, and 3% had low personal accomplishment. The overall burnout rate was 8.2%. Seventy-three percent of plastic surgeons enjoyed a good to very good quality of life. Great over-volume of work, mid-career practicing plastic surgeons and professional satisfaction with work were found to have a significant association with burnout on multivariate analysis.

Conclusions Plastic surgeons in India suffer an overall burnout rate of 8.2% with a multifactorial etiology. This occupational hazard is preventable and reversible. Plastic surgeons need to be vigilant about this and seek help whenever required.
External Validation of Three Burn-Specific Mortality Prediction Models in Adult Burn Patients at a Tertiary Care Hospital in India
Authors: Sharma Sneha , Tandon Raman
Published: January 2023

Background Several burn-specific mortality prediction models have been formulated and validated in the developed countries. There is a dearth of studies validating these models in the Indian population. Our objective was to validate three such models in the Indian burn patients.

Methods A prospective observational study was performed after ethical clearance on consecutive eligible consenting burn patients. Patient demographics, vitals, and results of hematological workup were collected. Using these. the Abbreviated Burn Severity Index (ABSI), the revised Baux score (rBaux), and the Fatality by Longevity, APACHE II score, Measured extent of burn, and Sex score (FLAMES) were calculated. The discriminative ability of the ABSI, rBaux, and the FLAMES was tested using the receiver operating characteristic (ROC) curve at 30 days and the area under the ROC curve (AUROC) compared. A p-value ≤ 0.05 was considered significant. Probability of death was calculated using these models. Hosmer–Lemeshow goodness of fit test was run.

Results The ABSI (AUROC 0.7497, 95% CI 0.67796–0.82141), rBaux (AUROC 0.7456, 95% CI 0.67059–0.82068) and FLAMES (AUROC 0.7119, 95% CI 0.63209–0.79172), had fair discriminative ability. The Hosmer–Lemeshow test reported that ABSI and rBaux were a good fit for the Indian population, while FLAMES was not a good fit.

Conclusion The ABSI and rBaux had a fair discriminative ability and were a good fit for the adult patients with 30 to 60% thermal and scald burn patients. FLAMES despite having fair discriminative ability was not a good fit for the study population.
Comparative Evaluation of the Increase in Enamel Hardness Post-External Bleaching after Using Casein Phosphopeptide Amorphous Calcium Phosphate Fluoride (CPP-ACPF) and 5% Sodium Fluoride (NaF) Remineralizing Agents
Authors: Irmaleny Irmaleny , Hidayat Opik Taofik , Yolanda Yolanda , Tobing Elisabeth Lumban
Published: January 2023

Objective The purpose of this study was to analyze the increase in enamel hardness post-external bleaching after remineralized with casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) and 5% sodium fluoride (NaF) and the difference in increased enamel hardness between CPP-ACPF and NaF materials.

Materials and Methods The study was true experimental in vitro using 30 samples of mandibular premolars. All samples were bleached using 40% hydrogen peroxide. The samples were divided into three groups of 10 samples each; group I as a control without application of remineralization material, group II was given an application of CPP-ACPF (GC Tooth Mousse Plus: GC Europe, Lot #201130B), and group III was given an application of 5% NaF (Clinpro White Varnish: 3M ESPE, Lot #NA62322) Then the entire samples were stored in artificial saliva. The hardness of the samples was measured using a Vickers hardness tester before bleaching, after bleaching, and after remineralization for 7, 14, and 21 days.

Statistical Analysis Analysis of the data used was an analysis of variance test to assess differences in the increase in enamel hardness between groups and paired t-tests and to determine differences in enamel hardness in each group.

Results This study showed that there was an increase in the enamel hardness after bleaching which was remineralized with CPP-ACPF and 5% NaF. There was a difference in the increased enamel hardness between teeth remineralized with CPP-ACPF and 5% NaF. The enamel hardness of CPP-ACPF was higher compared with 5% NaF after remineralization of 7, 14, and 21 days.

Conclusion There was an increase in the enamel hardness after external bleaching that was remineralized with CPP-ACPF and 5% sodium fluoride (NaF). There was a difference in the increased enamel hardness between teeth remineralized with CPP-ACPF and 5% sodium fluoride (NaF). CPP-ACPF showed a higher enamel hardness value than 5% NaF.
Occupational and Functional Outcomes following Patellofemoral Arthroplasty in U.S. Military Servicemembers
Authors: Fisher Tuesday F. , Rider Danielle E. , Waterman Brian R. , Belmont Philip J.
Published: January 2023

The functional outcomes in patients undergoing patellofemoral arthroplasty (PFA) with high occupational demands have not been fully examined. This study assessed return to work and conversion to TKA rates following PFA in a young, military cohort. Patient demographics, pain scores, and surgical information were retrospectively collected for all active-duty military members who underwent PFA over a 4-year period. The data were then analyzed to calculate return to work, conversion to TKA, and perioperative complications rates. A total of 48 servicemembers with 60 total PFAs (36 unilateral, 12 bilateral) were included, with a mean follow up of 2.2 years. At the final follow-up, 83% of servicemembers returned to military service or completed their service obligation after PFA. Conversion to TKA occurred in three (6.2%) patients at an average of 2.4 years after PFA, resulting in a PFA annual revision rate of 2.3%. The mean numeric rating scale for pain improved from 4.9 ± 2.6 at baseline to 2.5 ± 2.0 postoperatively (p < 0.001). Servicemembers with at least one prior ipsilateral knee procedure had a significantly decreased odds ratio (OR) for both occupational outcome failure (OR, 0.03; 95% confidence interval [CI], 0–0.29) and overall failure (OR, 0.13; 95% CI, 0.02–0.78). At an average of 2 years following PFA, 83% of military members returned to duty, with a low rate of revision to TKA. Prior ipsilateral knee procedure decreased the probability of medical separation.

Level of Evidence IV
Heterotopic Digital Replantation in Mutilating Hand Injuries: An Algorithmic Approach Based on 53 Cases and Literature Review
Authors: Chang Tommy Nai-Jen , Hsu Chung-Chen , Dafydd Hywel , Sachanandani Neil S. , Chen Lisa Wen-Yu , Chen Yi-Chieh , Lin Yu-Te , Lin Chih-Hung , Lin Cheng-Hung
Published: January 2023

Background Reconstruction of the mutilated hand is one of the most difficult challenges for hand microsurgeons. When multiple digits are amputated, orthotopic digital replantation of the available remnants may not adequately restore the hand function. In such cases, heterotopic digital replantation may provide a more functional reconstruction.

Methods Between 1997 and 2018, 53 patients with mutilating hand injuries were treated with heterotopic digital replantation at our institution. A retrospective chart review was conducted to determine the details of the injury, indications for heterotopic digital replantation, and functional outcomes.

Results In total, 173 digits were amputated from 53 patients (one patient suffered from bilateral hand injuries, so totally 54 hands). Sixty-eight digits underwent heterotopic digital replantation, 30 digits had orthotopic digital replantation, and 75 stumps were terminalized. The survival rate of digits treated by heterotopic digital replantation and orthotopic digital replantation was 83.8% (57/68) and 86.7% (26/30), respectively (p = 1). Tripod grip was achieved in 83.3% (45/54) of patients following replantation and optional secondary reconstructive surgeries.

Conclusion Heterotopic digital replantation is a practical and reliable method for achieving optimal hand function following mutilating hand injuries. The basic principles are to restore a functional thumb in the first instance, followed by at least two adjacent fingers against which the thumb can oppose. This method is particularly indicated when orthotopic digital replantation of the available amputated parts would yield a suboptimal result.
Electronic and optical properties of GaN/MoSe2 and its vacancy heterojunctions studied by first-principles
Authors: Ma Lei , Li Meng-Na , Zhang Li-Li
Published: January 2023

Heterojunction GaN/MoSe2 has recently piqued the interest of researchers due to its exceptional electronic and optical properties. Despite this, the higher rate of photogenerated carrier recombination limits their technical application. Implementing a promising approach to the formation of the 2D heterostructure with vacancies may improve photocatalytic activity. By first-principles, the stability, electronic structure, and optical properties of monolayer GaN and MoSe2, GaN/MoSe2 (GN/MS), GaN/MoSe2 with a Ga vacancy (VGa-GN/MS), GaN/MoSe2 with an N vacancy (VN-GN/MS), and GaN/MoSe2 with vacancies of Ga and N (VGa@N-GN/MS) are systematically computed. Compared with monolayer GaN, MoSe2, and GaN/MoSe2, the results show that vacancies do not destroy the stability of heterojunctions and cause a decrease in their bandgaps and a redshift of the absorption spectra. Type-II band alignment is observed through Perdew–Burke–Ernzerhof calculations in all heterostructures. VGa-GN/MS and VGa@N-GN/MS are p-type semiconductors, while VN-GN/MS is an n-type semiconductor. Based on the analysis of Mulliken occupancy, work function, and optical properties, we speculate that vacancies of Ga and N cause GN/MS to be energetically favorable for water splitting.
Magnetic strong coupling between rectangular hole metamaterials and Fabry–Pérot microcavity in THz region
Authors: Anzai Haruki , Inoue Shota , Tokizane Yu , Yoshida Hiroko , Yasui Takeshi , Shimokawa Fusao , Tsurumachi Noriaki
Published: January 2023

Various studies have so far been conducted on the strong coupling interaction between light and matter in microcavities. Although most of them report on the coupling between the electric field and the electric dipole, the coupling between the magnetic field and the magnetic dipole is rarely reported. In this study, we investigated the strong coupling interaction between a magnetic field and a magnetic dipole using a Fabry–Pérot microcavity structure in the THz region consisting of wire grid (WG) mirrors and rectangular hole (RH) metamaterials. Here, the RH is well known as a magnetic current type slot antenna, which can be regarded as a magnetic dipole. To verify this concept, we analyzed the transmission properties of WG, RH, and a microcavity consisting of WG and RH (WGRH) using the transmission line theory. Consequently, we found that in this WGRH, normal mode splitting occurs, and anti-crossing behavior is observed in the dispersion relation. The samples were designed using the finite difference time-domain method and were fabricated via photolithography. We measured the transmission spectrum of the fabricated samples using THz time-domain spectroscopy. Finally, we observed a splitting of the transmission peak owing to mode coupling between the magnetic field and the magnetic dipole in WGRH.
Effect of material composition of diamond field emission array cathodes on quality of transversely shaped beams
Authors: Schneider Mitchell E. , Andrews Heather , Baryshev Sergey V. , Jevarjian Emily , Kim Dongsung , Nichols Kimberley , Posos Taha Y. , Pettes Michael , Power John , Shao Jiahang , Simakov Evgenya I.
Published: January 2023

Diamond field emitter array field emission cathodes (DFEA FECs) are attractive for the next generation of injectors due to their ability to produce transversely shaped beams without the need for complex masking or laser schemes. However, reliability of this cathode technology remains a challenging issue as principal mechanisms guiding and allowing for output beam shaping remained poorly understood. This paper reports the results of testing two DFEA FECs with the same pattern and emitter tip geometry. Although both cathodes were able to sustain gradients of 44 MV/m and produce maximum output integral charge of 0.5 nC per radio frequency pulse, their emission patterns were different. One cathode did not produce a shaped beam, while the other one did. This difference was explained by the extent of the local variations of the diamond material across the arrays as discovered by spatially resolved Raman spectroscopy. The main practical takeaways were (i) tip sharpness was not a prerequisite for producing a shaped beam and instead (ii) material characteristics resulting in different cathode ballast resistance affected emission spatial uniformity across the array and hence the beam shaping.
Kinetic modeling of solitary wave dynamics in a neutralizing ion beam
Authors: Nuwal Nakul , Levin Deborah A. , Kaganovich Igor D.
Published: January 2023

In this work, we characterize the formation and evolution of electrostatic solitary waves (ESWs) in the space-charge neutralization of ion beams using particle-in-cell simulations. These waves become excited when the electrons emitted from an external filament source initiate a two-stream instability in the beam. We show that such electrostatic waves become excited in both two-dimensional (2D) and three-dimensional (3D) beams with different shapes and sizes. Through a 1D Bernstein–Greene–Kruskal (BGK) analysis of the 2D beam, we find that the non-Maxwellian nature of the beam electrons gives rise to large-sized ESWs that are not predicted by BGK theory since it assumes a Maxwellian electron velocity distribution in the beam. Finally, we show that a 1D BGK theory is inadequate to describe ESWs in 3D beams because of complex electron trajectories.