bluuebunny/crossref_metadata_2025 huggingface dataset:
DIALECTIC AND EXISTENCE IN KIERKEGAARD AND KANT
Authors: De Oliveira Nythamar Fernandes
Published: July 2019

Este artigo procura examinar em que medida a filosofia moral de Kierkegaard se apóia na crítica kantiana da razão dialética. Mostra-se que a rejeição kantiana da prova ontológica da existência de Deus significa um afastamento da incerteza objetiva em direção à certeza prática, enquanto a dialética kierkegaardiana da existência permite que a verdade seja tomada como sendo tanto pessoal quanto objetiva. Se a concepção kierkegaardiana de existência não pode ser separada do Paradoxo Absoluto ou se nem sequer pressupõe a revelação divina parece guiar uma pré-compreensão da oposição luterana entre fé e razão que persiste nas concepções de natureza humana em Kant e Kierkegaard, com relação ao Todo-Outro.
JUSTIÇA, LIBERDADE E ALTERIDADE ÉTICA – SOBRE A QUESTÃO DA RADICALIDADE DA JUSTIÇA DESDE O PENSAMENTO DE E. LEVINAS
Authors: De Souza Ricardo Timm
Published: July 2019

O objetivo desse artigo é caracterizar o que consideramos serem algumas das dimensões essenciais para a compreensão da questão da justiça desde a inspiração geral do pensamento da alteridade ética do filósofo lituano-francês Emmanuel Levinas (1906-1995).
APONTAMENTOS SOBRE A EDUCAÇÃO ESTÉTICA
Authors: Paviani Jayme
Published: July 2019

Caracterização das relações entre estética e educação a partir das noções de experiência, percepção e juízo estético.
DEMOCRATIZAÇÃO E GLOBALIZAÇÃO – É possível uma gestão democrática dos processos de globalização econômica, social e política?
Authors: Pinzani Alessandro
Published: July 2019

O controle político sobre o fenômeno da globalização, que é um fenômeno predominantemente econômico, é possível, mas requer que os Estados particulares acelerem o processo de integração internacional e criem uma ordem jurídica global. Neste texto, serão apresentadas e refutadas algumas objeções (falta de realismo, caráter não-democrático, distância demasiada dos cidadãos) a tal ordem.
ESTÉTICA E ÉTICA NA TERCEIRA CRÍTICA
Authors: De Oliveira Nythamar Fernandes
Published: July 2019

Trata-se de reexaminar a relação entre estética e ética na terceira Crítica, partindo de uma análise crítica do livro de Donald Crawford sobre a teoria estética de Kant, com O intuito de evitar o que seria uma “leitura reducionista” da filosofia kantiana. Assim como fora reduzida a uma Erkenntristheorie pelos adeptos da escola neokantiana de Marburg, parece-nos igualmente infundada uma leitura da filosofia prática de Kant que reduza o sistema do idealismo transcendental a um moralismo ou que venha a subvertê-lo num esteticismo (pós-moderno). Ao retomar a teoria kantiana das representações, procuro responder aos problemas levantados pela leitura esteticista da crítica do juízo, particularmente, a concepção do belo enquanto símbolo fundante da moralidade, à luz do debate entre Donald Crawford e Paul Guvyver, de forma a mostrar em que sentido a “estética” (lato sensu) pode compreender um sentido “epistemológico” e “estético propriamente dito” (stricto sensu) sem incorrer numa forma de esteticismo.
FÉ E RAZÃO - Pronunciamento do Magnífico Reitor da PUCRS, Ir. Norberto Rauch, na abertura do Colóquio Fé e Razão, no dia 1 de junho de 2001, no auditório do prédio 11 da PUCRS
Authors: Rauch Norberto
Published: July 2019

Crônica
Uma estratégia para introduzir conceitos de física no Ensino Fundamental: o uso dos paradigmas kuhnianos
Authors: Matos Jenifer Andrade de , Massoni Neusa Teresinha
Published: July 2019

Este texto narra a aplicação de uma estratégia didática para introduzir conceitos de Física a estudantes do Ensino Fundamental, buscando gerar uma experiência positiva nos alunos e possibilitar que estes construam uma visão de ciência alinhada a visões epistemológicas contemporâneas. A sequência didática abordou, a partir da epistemologia de Thomas Kuhn, o tema da queda dos corpos sob três diferentes paradigmas: o paradigma de Aristóteles, do lugar natural; o de Newton, da Gravitação Universal; e o de Einstein, da Teoria da Relatividade Geral. Os resultados de sucessivas aplicações têm sido promissores, pois os estudantes engajam-se, parecem compreender que as diferentes formas de explicar um mesmo fenômeno que nos é cotidiano mudam com o tempo e, com isso, passam a ver a ciência como algo passível de rupturas, de crises e de reinvenções na busca de novas bases capazes de sustentar as novas explicações.
O educar pela pesquisa e o ensino de ciências: perspectivas de uma aprendizagem significativa
Authors: Cabreira Maurício Costa , Ignácio Patrícia , Trombetta Fernanda , Milani Raquel
Published: July 2019

O presente estudo, por meio de um levantamento bibliográfico, busca pontos de convergência entre o ensino de Ciências e o Educar pela Pesquisa, na perspectiva de uma aprendizagem significativa. O entendimento da pesquisa em sala de aula ancora-se nos pressupostos do Educar Pela Pesquisa com Demo (2003) e Galiazzi (2014), e diante das reflexões sobre o ensino de Ciências de Pozo e Crespo (2009), buscam-se nos conceitos de Ausubel pontos de intersecção que identifiquem uma aprendizagem significativa. Pelo conjunto de dados apresentados e analisados nesta pesquisa, nota-se que um dos pontos de intersecção entre o ensino de Ciências e a pesquisa em sala de aula resulta em uma aprendizagem significativa, na qual o foco não é a transmissão mas a investigação, e através dela, partir de conhecimentos prévios atribuindo significado ao que se está aprendendo. O Educar pela Pesquisa se constitui também como um importante meio para a atuação do sujeito em sociedade e promoção da cultura da pesquisa na escola, fazendo com que os estudantes superem a visão da Ciência com base no conhecimento cotidiano e transitem do senso comum e dos conhecimentos prévios para um conhecimento científico.
Investment on wheat research and its effect: A case of Nepal
Authors: Timsina K.P. , Gairhe S. , Koirala P. , Shrestha J.
Published: July 2019

Abstract. Although the agriculture sector markedly contributes to the Nepalese economy, very little is known about the government’s investments in agricultural research activities and how these investments have impacted the sector. In this study, we picked a case of wheat crop as it is the third largest crop of Nepal in terms of total annual production. We took government’s annual wheat research investments of Nepal from Fiscal year 2005 to 2016 to analyze the effects of investment on wheat research based on the availability of data. We used compound growth rate, averages, trend line, and bar diagram to present the data and interpret the results. Results revealed that the share of operational budget was lower than supposed to be allocated for the development of wheat research. The pace of increment of wheat production and productivity were observed due to improved wheat investment and technologies. Result shows the negligible spillover effect from neighboring countries in wheat production. Even though the Nepal Agricultural Research Council (NARC) has fulfilled source seed target by producing a surplus, private sectors should involve proactively in coordination with NARC to meet the projected demand of wheat seed in national seed vision. The huge gap was observed between yield potential and average national productivity. To achieve greater impact of wheat research in Nepal, it is necessary to bridge the gap by awareness program, making the availability of improved seed with an improved package of practices.
A Pilot Study of Sirolimus in Subjects with Cowden Syndrome or Other Syndromes Characterized by Germline Mutations in PTEN
Authors: Komiya Takefumi , Blumenthal Gideon M. , DeChowdhury Roopa , Fioravanti Susan , Ballas Marc S. , Morris John , Hornyak Thomas J. , Wank Stephen , Hewitt Stephen M. , Morrow Betsy , Memmott Regan M. , Rajan Arun , Dennis Phillip A.
Published: July 2019

Lessons Learned

This is the first human interventional study in patients with Cowden syndrome that is driven by inactivation of germline PTEN gene. Single-agent sirolimus, a mTOR inhibitor, suppressed mTOR signaling in surrogate human tissues without significant toxicity.

Background

Cowden syndrome is characterized by inactivating germline PTEN mutations, which can lead to activation of the PI3K-Akt-mTOR pathway.

Methods

Adult subjects with germline PTEN mutation who met international diagnostic criteria for Cowden syndrome and who had Eastern Cooperative Oncology Group (ECOG) performance status 0–2 and adequate organ function were enrolled. Subjects were treated with a 56-day course of daily oral sirolimus. In addition to symptom assessment and physical examination, dermatologic, endoscopic, neurologic (cerebellar), and radiographic assessments were conducted. Inhibition of the mTOR pathway in benign skin and gastrointestinal (GI) lesion was assessed by immunohistochemistry.

Results

A total of 18 patients and 16 families were enrolled. PTEN mutations were located at exons 1–8. Regression of skin and GI lesions was observed by dermoscopy or endoscopy. Neurological evaluation showed improvement in cerebellar function score at 1 month. Immunohistochemistry (IHC) analysis in skin and GI benign lesions showed a decrease in the ratio of phosphorylated (p)S6 to total S6 in response to sirolimus. Ratios of pS6K to total S6 at days 14 and 56 were significantly lower than at baseline (p = .0026, p = .00391, respectively). A 56-day course of sirolimus was well tolerated.

Conclusion

A 56-day course of sirolimus was well tolerated in subjects with Cowden syndrome and was associated with some evidence of improvement in symptoms, skin and GI lesions, cerebellar function, and decreased mTOR signaling.
Evaluation of indoor environmental conditions in university classrooms
Authors: Yildiz Yusuf , Koçyiğit Merve
Published: July 2019

Analysing learning environments is important because classrooms can affect students’ well-being and learning performance. In this paper, a field study was conducted based on a mixed method for a better understanding of indoor environmental conditions in six buildings of Balikesir University in Turkey. The perceptions of students were combined with measurements and surveys. The environmental parameters such as indoor and outdoor air temperature, indoor black globe temperature, indoor and outdoor relative humidity, indoor carbon dioxide concentration and air velocity were measured. A total of 1782 responses from students were also obtained. The recorded values of mean indoor air temperature, relative humidity, black globe temperature and air velocity were 23·4°C, 39·8%, 22·9°C and 0·09 m/s, respectively. Carbon dioxide concentrations usually exceeded the threshold of 1000 ppm. Over 55% of students said they found indoor conditions thermally acceptable in all classrooms during the field study. The mean neutral temperatures, as predicted by actual and predicted mean values, were 21·7 and 23·1°C. Indoor measured temperatures were mostly found to be higher than neutral temperatures. The findings can be used for the design and evaluation of indoor conditions and heating systems in university buildings.
Validación de contenido de una rúbrica para evaluar la competencia oral de una lengua extranjera desde la socioformación
Authors: Mounkoro Ismaila , Veytia Bucheli María Guadalupe
Published: July 2019

Esta investigación surge de la carencia de herramientas para calificar la competencia oral de una lengua extranjera que sea pertinente a las apuestas de la sociedad del conocimiento sujeto al enfoque de la socioformación. El propósito fue realizar la validación de contenido de una herramienta para calificar la competencia oral de una lengua extranjera en el nivel B1. Para esto se empleó un estudio instrumental según las siguientes fases: 1) elaboración de una herramienta a través de un esquema tipo socioformativo; 2) revisión y mejora de la herramienta por parte de tres expertos; 3) validación de contenido por un jurado de 16 expertos en el campo. Los resultados obtenidos indican que la herramienta es adecuada para calificar la competencia oral de una lengua extranjera, con una V de Aiken superior a V 0.75. La Confiabilidad inicial fue de 0.842. Conclusiones: la rúbrica es adecuada; sin embargo, hay que implementarla a un público más amplio, con el fin de definir la validez del constructo.
Justicia liberal: teleología y cosmovisión
Authors: Aranda Fraga Fernando
Published: July 2019

La doctrina filosófica y económica de la “mano invisible” fue formulada por el filósofo escocés Adam Smith (1723-1790), quien es hoy considerado uno de los mayores exponentes de la economía clásica, como así también el padre de la economía política. Su obra capital es La riqueza de las naciones. La tesis principal de su obra es que la clave del bienestar social radica en el crecimiento económico y este se potencia mediante una adecuada división del trabajo y la competencia entre seres humanos libres, iguales y relativamente egoístas. Aquí se analiza cómo ello surgió durante la Modernidad, e incluso profundizando en la escolástica tardía, rastreando en Ockham sus remotos orígenes, la doctrina liberal de los derechos y de la seguridad; en definidas cuentas, la idea de justicia y la cosmovisión que la sostiene. En el interregno de ambas épocas no es posible eludir el hecho contundente de la transformación del derecho natural en derecho positivo y su impacto en la política, la sociología y la economía. Esta escuela se completa y aplica mayormente a la economía y la teoría social contemporáneas con el desenlace teórico sobre la teoría liberal de la justicia que desarrolló John Rawls, especialmente entre los años 1971-1995. A estas conexiones y su crítica nos dedicaremos en lo que sigue.
Оптика медико-демографических процессов в контексте устойчивого развития арктического макрорегиона (на примере Архангельской области)
Authors: Ревич Борис Александрович , Харькова Татьяна Леонидовна , Кваша Екатерина Александровна
Published: July 2019

Сохранение и укрепление здоровья населения обозначены как приоритеты развития в Государственной программе «Социально-экономическое развитие Арктической зоны Российской Федерации на период до 2020 года». В статье анализируются тренды ожидаемой продолжительности жизни, смертности от основных причин смерти и младенческой смертности в одном из наиболее крупных по числу жителей регионов Арктической зоны Российской Федерации – части Арктического макрорегиона Архангельской области. Рассматривается дифференциация смертности от основных групп причин смерти, включая болезни системы кровообращения (БСК), новообразования, внешние причины смерти, болезни органов дыхания и пищеварения, инфекционные заболевания и некоторые другие причины в гг. Архангельске, Северодвинске, других городах области и в сельской местности. Анализ основан на стандартизованных коэффициентах смертности (СКС) по причинам смерти.

Уровень смертности в Архангельской области выше среднероссийских показателей, особенно у мужчин. Наиболее низкая смертность отмечается в Архангельске и Северодвинске, несколько выше – в средних и малых городах и значительно выше – в сельской местности.

Структура причин смерти во всех группах поселений более чем на 80% определяется БСК, новообразованиями и внешними причинами, но при этом везде отмечается небольшое снижение доли БСК и внешних причин и более значительный рост доли новообразований. Архангельск характеризуется более высоким уровнем СКС от новообразований. Смертность от внешних причин отличается значительной дифференциацией по группам поселений. Однако СКС от случайных отравлений алкоголем во всех группах находится на одном уровне.
High-molecular weight DNA extraction from challenging fungi using CTAB and gel purification v2
Authors: Jones Ashley , Nagar Ramawatar , Sharp Anna , Schwessinger Benjamin
Published: July 2019

Extracting pure high-molecular weight DNA from some fungal species is difficult due to the presence of polysaccharides and potentially other compounds which biochemically mimic DNA or interfere with the DNA extraction process. Such compounds can co-elute with DNA in many extraction methods, being difficult to separate fom the DNA. Although the contaminant may not be detected by spectrophotometers or fluorometric devices, it substantially interferes with long-read DNA sequencing, such as Oxford Nanopore Technologies. To partially resolve this, a protocol is presented with some updates to current strategies and incorporates a gel purification with a Pippin Prep (Sage Science). Using this protocol, we have been successfully sequencing the wheat stripe rust Puccinia striiformis and leaf rust Puccinia triticina with a MinION (Oxford Nanopore Technologies). Sequencing yields have surpassed 4 gigabases with an N50 of approximately 30 kb. To increase sequencing output, more work is needed to identify and remove the elusive contaminants.
Culturing C. elegans worms in liquid culture v1
Authors: Riccio Cristian , Kosalka Asia , not provided WormBook
Published: July 2019

Growing C. elegans worms in liquid culture
Preparing 10 L of M9 buffer for nematode culture v3
Authors: Institute media kitchen Gurdon
Published: July 2019

Prepare 10 litres of M9 solution for collecting and washing C. elegans.
Features of interhemispheric functional connectivity In the brain of military man with traumatic brain injury during the realization of a simple sensorimotor reaction
Authors: Knyr A. , Filimonova N. , Makarchuk M. , Cheburkova A. , Zyma I. , Kalnysh V.
Published: July 2019

This study involved 16 male volunteers, right-handers, ages 18-21, without complaints of health – students of Taras Shevchenko National University of Kyiv (control group) and 16 male volunteers, right-handers, aged 27-43, military men who took part in the operations in the east of Ukraine and have craniocerebral injuries (ССI), later – military men with CCI – patients of the Yu. I. Kundiyeva Institute for occupation health NAMS of Ukraine, Kiev. EEG-study, coherent analysis and analysis of brain activity dipoles showed that in the realization of a simple sensorimotor reaction in the control group, the processes of target detection, mental imagery and planning of the motor response, organizing and performing movements that were consistent with the basic processing of visual information, dorsal and ventral visual streams and the integration of separate elements into a integral image. At the same time, verbal decision-making processes, executive control and coordination of behavior were also involved, based on the processing of current sensory information. Thus, the control groups were matched with coordinated front-parietal neural networks of different scales for the target detection, planning and execute volitional movements with the dominant control of the frontal cortex. In the military men with CCI, an interhemispheric relationship was found in the sensorimotor cortex with the dominant role in the realization of a simple sensorimotor reaction of the visual and parietal cortical areas. Since there were no significant differences in the latent periods of simple sensorimotor reaction between the control group and the group of military men with CCI, it can be assumed that the loss of front-parietal interaction in the military men with CCI was compensated for its realization by more effective inclusion of cortical brain zones associated with verbal processes of semantic analysis of visual information, which came mainly from the dorsal visual stream. In this case, instead of the higher control of such reaction from the frontal cortex, the control of the motor response may be assumed by the higher associative zones of the parietal cortex.
THE NOTION OF STYLISTIC PARADIGM IN THE LANGUAGE
Authors: Danylych Valentyna
Published: July 2019

The article focuses on stylistic aspects of the notion of linguistic paradigm, which is not limited only with lexis, but includes phonetics, morphology, syntax.
PROBLEMS OF RESTITUTION OF IMPLICATURES OF THE UKRAINIAN ARTISTIC WORK IN THE FRENCH TRANSLATION
Authors: Kyrylova Vira
Published: July 2019

The article investigates the research of features of restitution of implicatures of the Ukranian novel of Mykhailo Kotsiubynsky "The Shadows of Forgotten Ancestors" in French translations made by Emile Kruba («Les ombres des ancêtres disparus») and by Jean-Claude Marcadé («Les ombres des ancêtres oubliés»).
ON ANTECEDENTS OF PARONYMY IN ANTONIO MACHADO’S LYRICS
Authors: Obruchnykova Olena
Published: July 2019

The article investigates the peculiarities of the poetic language of the Spanish poet Antonio Machado considering the phenomenon of paronymy (paronymic attraction) – a special kind of phonetic repetition, in which the sound resemblance of two or more unrelated word forms induce a semantic link between them. Poetry of A. Machado is characterized by a variety of both lexical and phonetic repetitions. Although pairs of word forms, which by their phonetic structure, could be defined as the examples of paronymic attraction, are common for the poet’s lyric, the system is rather potential than fully realized. For the "real" paronymy of the poetic system, A. Machado lacks the phonetic contrast of the attractants with the closest context and semantic contrast of the given semantic connection between the attractants with the usual vocabulary connection. A further study of paronymic attraction may be aimed at identifying the dominant types of paronymy in the poetry of A. Machado in terms of structural classification, as well as the study of paronymy as a stylistic tool in the rhyme in the poet's work.
PASSIVE PHRASE FUNCTIONAL PERSPECTIVES AND «TEXTUALE LINGUISTICS»
Authors: Polishchuk Nadiya
Published: July 2019

The given article is dedicated to the problems of semantic analyses of passive phrase.
LEXICO-SEMANTIC AND MORFOLOGO-SYNTACTIC FEATURES OF CONSTRUCTING TEXTS OF SPANISH LAW
Authors: Vlasenko Mary
Published: July 2019

The article is devoted to the peculiarities of selection of linguistic means for creating different types of Spanish legal documents on lexical-semantic and morphosyntactic levels.
IMPLEMENTATION OF THE STATE AGRARIAN PROGRAMME IN THE USSR OF THE SECOND HALF OF THE 1920s AND THE BEGINNING OF THE 1930s
Authors: Melnikova T. A.
Published: July 2019

The article presents the review of realization of the state agrarian programme of the Soviet state in the second half of the 1920s and the beginning of the 1930s. The change of labour relationship in agriculture,the period of the new economic policy have been analyzed in detail. The process of agrarian reforms in the country aimed at transformation of peasant community into a part of a state system as well as state policy concerning villages have been considered.
Autotomía caudal como herramienta estratégica prospectiva ante un cambio de época en organizaciones públicas
Authors: Buitrago Ramiro Aurelio , El kadi Janbeih Omar Nabih
Published: July 2019

Objetivo: Comprender de qué forma la autotomía caudal pudiera favorecer el desarrollo de procesos blandos con origen en organizaciones del sector público, advirtiendo la naturaleza del fenómeno y sus implicaciones prácticas como herramienta estratégica y prospectiva. Materiales y métodos: Se considera del tipo documental con diseño bibliográfico, donde se aplica la técnica de observación etnográfica digital para el análisis e interpretación de contenidos. Resultados: Se logró reflexionar sobre el fenómeno abordado, confrontando diversas teorías con respecto a este y su influencia sobre el comportamiento humano y organizacional en un país donde la administración pública experimenta transformaciones de distinto orden. Discusión: El contexto político venezolano ha experimentado una deconstrucción sustancial en los estamentos de la gestión pública, exponiendo sobre la palestra política nacional cierto interés por alcanzar un estatus mucho más orgánico en el ejercicio del poder por parte de los actores políticos en cargos públicos con prerrogativas de alto alcance.
La Ventanilla Única de Certificación Ambiental en Panamá
Authors: Antúnez Sánchez Alcides , Batista Rodríguez Alcibiades
Published: July 2019

En el siglo XXI la modernización del sector público impulsado por el gobierno digital ha desencadenado una serie de aspectos positivos y negativos para los ciudadanos; las reformas innovadoras que ha sufrido el ambiente gubernamental con las políticas de fomento ha sido el gobierno digital. El uso de las Tecnologías de la Informática y las Comunicaciones busca reformar los procesos de gestión pública, vincula a los ciudadanos con la Administración Publica como la herramienta que disminuya la carga burocrática en los trámites, promover la participación ciudadana, fortalecer la confianza en el Estado, viabilizar e incrementar la transparencia y la rendición de cuentas. Su implementación ha traído la modificación de los modelos y políticas de gobierno con una relación jurídica telemática.
ENTENDER EL EMPRENDIMIENTO PARA SOLUCIONAR LA PROBLEMÁTICA ECONOMICA Y SOCIAL
Authors: Sarmiento Del Valle Santiago
Published: July 2019

En los últimos años se buscan soluciones para reducir los preocupantes índices económicos y sociales que afectan a la mayoría de los países del mundo. Una opción aceptada y reconocida es fomentar el emprendimiento y creación de empresas, desarrollando programas, políticas gubernamentales y privadas. Sin embargo, al momento de evaluar sus resultados surgen interrogantes y dudas que nos llevan a reflexionar más profundamente acerca de cuáles serían las mejores alternativas para aminorarlas. Este artículo de reflexión pretende motivar a los distintos grupos de interés a encontrar causas y consecuencias que no han permitido en Colombia mejores resultados, además, realizar comparativos con países de América Latina con el fin de emular experiencias, pero más que eso, proponer a la luz de la real situación del contexto nacional e internacional, soluciones coherentes y viables
Hacia la construcción de una teoría de la Felicidad Laboral 3.0 con fundamento de Bertrand Russell|
Authors: Collazos Fajardo Carlos , Blandón Blandón Gloria
Published: July 2019

En este artículo de reflexión, se toma como fundamento, los aportes epistemológicos del escritor Bertrand Russell (2005) en su obra: La Conquista de la Felicidad y se concentra en el análisis de los preceptos teóricos del autor; específicamente en el Capítulo 14, intitulado: El trabajo y el Capítulo 17 denominado: El hombre feliz. En tal sentido, se inicia con un acercamiento a los postulados del autor, resaltando algunas ideas claves sobre el tema de la felicidad en relación con el trabajo, luego, en un segundo momento se exponen algunas reflexiones y aportes propios y se finaliza con las conclusiones en relación con el tema. La idea central de la reflexión consiste en cómo, los postulados de Bertrand Russell aportan para la construcción de una nueva teoría administrativa denominada: Felicidad Laboral 3.0 y los elementos que le integran tales como: El Mentor, el Talento y el Ambiente Laboral. Collazos (2018)
Prevalence and impact of adiposity and sarcopenia during rheumatoid arthritis: rapid and non-invasive evaluation in Sub-Saharan African women
Authors: Touré Maïmouna , Diagne Mouhamed T. , Badji Amadou , Thiam Souleymane , Diouf Coumba , Niasse Moustapha , Sene Mbaye , Sow Abdou Khadre , Seck Aissatou , Houndjo Salimata D. , Diaw Mor , Mbengue Arame , Sar Fatou Bintou , Bâ Abdoulaye , Diallo Seydou , Samb Abdoulaye
Published: July 2019

Background: Body composition plays a fundamental role in the occurrence of complications in rheumatoid arthritis. Authors conducted this study, which aimed to determine body composition and its effects on physiological status in African sub-Saharan polyarthritis women.Methods: The anthropometric parameters were measured after an interview and a complete physical examination. The body composition was evaluated using a Tanita® brand bioimpedance meter. Finally, all the patients had a dosage of certain biochemical parameters.Results: An excess of percent fat mass was noted in more than half of women (59.52%) without loss of muscle mass. At the same time, 30% of women had a significant decrease in the percentage of body water. The BMI did not appear to be an adequate proxy for these changes. Visceral fat level was elevated just in 16% of women, however it would be a determinant of physiological aging of subjects. Dual therapy methotrexate and corticosteroid would have varying effects depending on the duration and the dose of treatment. The basic metabolism in polyarthritic subjects would be dependent on two parameters namely muscle mass and inflammatory state.Conclusions: Evaluating changes in body composition quickly, non-invasively and inexpensively is possible. It could be useful in the follow-up of rheumatoid arthritis. Managing these changes can reduce cardiovascular morbidity and mortality in rheumatoid arthritis.
Serum gamma-glutamyl transferase level in acute stroke
Authors: Singh Lagendra Kumar , Pradhan Sourabh , Dash Laxmikanta , Pradhan Jagannath , Raul Umakanta , Meher Rajesh Kumar
Published: July 2019

Background: Stroke is the second leading cause of death worldwide, causing 6.2 million deaths in 2011. Serum Gamma-Glutamyl Transferase (GGT) has been conventionally considered as a marker of excessive alcohol intake and/or liver dysfunction. There are accumulating evidences suggesting association of raised serum GGT level in stroke. So, this study was conducted to determine the association between the serum GGT level and stroke in population without history of alcohol consumption.Methods: This cross-sectional comparative study was carried out at Department of General medicine, Veer Surendra Sai Institute of Medical Sciences and Research (VIMSAR), Burla from November 2016 to October 2018. 100 cases and 100 controls were included in this study. Cases were the patients admitted to Department of General Medicine, VIMSAR, Burla, presenting within 24 hours of first episode of stroke. Controls were the age (+/-5 years) and sex matched healthy attendants of the patients. Alcoholics or patients suffering from hepatitis, cirrhosis of liver, cholestasis or patients taking drugs like Phenytoin, Valproic acid, Carbamazepine etc or patients with past episode of stroke were excluded from this study. Serum GGT level of both cases and controls were measured and compared.Results: In stroke patients, the mean serum GGT level was 54.95 IU/L with standard deviation of 20.54. In controls, the mean serum GGT level was 32.14 IU/L with standard deviation of 5.07. The p-value was less than 0.0001 i.e. highly significant.Conclusions: Serum GGT level is significantly increased in stroke patients than healthy persons without stroke.
Simple vs ugly adnexal lesions: is ultrasonography alone good enough?
Authors: Chauhan Rahul Dev , Mathur Yashvir
Published: July 2019

Background: Ultrasound (USG) is easily available and effective imaging modality for adnexal lesions. A simple looking lesion on ultrasound is usually benign and an ugly looking adnexal lesion is either benign or malignant. This study aims to evaluate the varied appearance of simple and ugly benign adnexal lesions on USG and to find out any additional role of colour Doppler in such suspected benign lesions. The confirmation of diagnosis was done either by follow up appearance of lesions on USG or by histopathological evaluation.Methods: A total of 55 consecutive female patients with age between 18 to 50 years were enrolled in this prospective cross sectional study. USG and colour Doppler for all the lesions were done. The patients found to have malignant lesions on histopathological examination, were later excluded from the analysis. Follow up USG was done for all the cases. Those cases wherein there was no resolution of lesions even after 08 weeks, were given an option to undergo laparoscopy as next management step.Results: Out of 50 benign adnexal masses, 88% masses were ovarian in origin and 12% were tubal masses. Ovarian masses included hemorrhagic cysts, endometriosis, simple cysts, serous cystadenomas and ovarian dermoid. All extra-ovarian masses were hydrosalpinx. Colour Doppler did not add any additional finding. Some of the patients underwent diagnostic laparoscopy followed by excision of masses in majority of them.Conclusions: Benign adnexal lesions can have varied appearance ranging from simple to ugly on USG. Ultrasonographic features of benign lesions on USG can be appreciated very well even without further use of colour Doppler or cross sectional imaging. Follow up USG remains key modality for benign adnexal masses in absence of MRI.
Three port versus four port laparoscopic cholecystectomy: a prospective comparative clinical study
Authors: Bari Shams Ul , Islam Faheem Ul , Rather Ajaz A. , Malik Ajaz A.
Published: July 2019

Background: Although, traditional laparoscopic cholecystectomy is performed using four-port technique, various modifications were made to further enhance the advantages of laparoscopic cholecystectomy. Aim of the study is to compare the results of three-port and four-port laparoscopic cholecystectomy at single center in terms of technical feasibility, safety of the procedure, operative time, intra-operative complications, postoperative pain and post-operative analgesia requirementMethods: It was a  prospective comparative study conducted  in the department of surgery Skims Medical college Srinagar, India from July 2015 to March 2017. The study was performed on all adult patients with ultrasound documented cholelithiasis and gall bladder Polyposis. The total number of patients studied was 100 which were divided into two groups of 50 each.Results: The average operative time in three port group was 29.2 minutes (range, 15-37) compared to 30.66 minutes (range, 15-42) in four port group, which was statistically insignificant. The final visual analog scores for pain in the postoperative period was 2.30 vs 2.86 in three port and four port group respectively, with a P value=0.008, which was statistically significant.Conclusions: The three-port technique is as safe as the standard four-port technique and can be a viable alternative to four port cholecystectomy with an advantage of less pain and less analgesic requirement and better cosmetic results.
A rare case of multilocular cystic renal neoplasm of low malignant potential diagnosed on intra-operative FNAC
Authors: Patel Mandakini M. , Gamit Bhavna N. , Patel Sharmishtha I. , Patel Mubin I. , Gandhi Priyanka S.
Published: July 2019

Multi-locular Cystic Renal Cell Carcinoma (MCRCC) is now considered as Multilocular cystic renal neoplasm of low malignant potential (MCRNLMP) in World health organisation classification (WHO) 2016. It is usually seen in elderly people where it can mimic most of the time as benign cystic lesion. Authors are reporting a case of MCRNLMP in a 70 year male diagnosed intraoperative with the help of FNAC. Radiological and other clinical findings are in favour of cystic renal lesion. And it is very important to differentiate it from conventional renal cell carcinoma which requires radical nephrectomy. So, radiological finding and FNAC is instrumental in diagnosing this rare case which require different mode of surgical management.
Extra note of music in anaesthesia
Authors: Kaur Harpreet , Shukla Veena , Bansal Gopal Lal , Harsh Harsh Kumar , Joseph Anie , Bharadwaj Meghana S.
Published: July 2019

Role of music has been identified since ancient times for alleviating anxiety. Music has been known for its potential to produce a sense of wellbeing and peace. Anaesthesia and surgery are major stress factors for any person. Preoperative anxiety is a usual phenomenon in patients posted for various surgical interventions as well as those admitted to intensive care units (ICU). Literature shows ample evidence regarding neurohormonal disturbances related to stressful situations like preoperative, intraoperative and post-operative periods. Music has been shown to attenuate release of various biochemical molecules leading to relaxing and sedative effects on the brain. Not only patients under regional anaesthesia who are awake have a positive impact, even patients under general anaesthesia have also been shown to benefit from listening to music intraoperatively. Music is a hazard free intervention which can be added to various drug combinations used by anaesthesiologists.
Post burn flexion contracture of hand: a prospective study
Authors: Lakshmi Bai Subbu Pilla , Gunasekaran Raman
Published: July 2019

Background: Burn contracture of the hand can cause severe functional and psychological deprivement in patients. This study mainly concentrates on different types of hand deformity cases presenting to our department and the various options used to correct them. The postoperative functional outcome is also compared so that standardization of procedures can be done. This study assesses the severity of the deformity, the success of various reconstruction options and the functional outcomes of cosmetic procedures.Methods: This work includes the study of 60 patients who underwent reconstruction for post-burn flexion contracture of the hand including fingers, in the department of plastic surgery, Government Rajaji Hospital, Madurai. The patients were treated between September 2009 to February 2012.Results: Males were twice commonly affected by burn injuries and thermal burns were more common than electrical burns. The little finger was more frequently involved and contracture release followed by grafting was the commonly done reconstructive procedure. Complications like recurrence, residual contracture, partial graft loss and infection were noted.Conclusions: Contracture release by multiple Z–plasty with or without skin grafting was sufficient in most cases of contracture due to thermal burns. Flaps were required for reconstructing electrical burns. Complication rates are higher in children than in adults and postoperative physiotherapy and splinting is mandatory to achieve a better functional outcome.
Analysis of complications and management of abdominal stoma
Authors: Pal Naresh , . Poonam , Jangra Amit , Mishra Vineet
Published: July 2019

Background: Abdominal stoma is an opening of the intestine whether temporary or permanent on anterior abdominal surgically. These are used to divert the faecal contents for safe distal anastomosis and to relieve obstruction in emergency surgeries or even in elective surgeries also. Though it is a lifesaving procedure and may be temporary or permanent. Sometimes it may result in number of significant complications which may be starting from early postoperative periods to late compilations.Methods: This is a prospective observational study, which was carried on 85 patients of abdominal stomas in the department of general surgery, Pt. B D Sharma PGIMS Rohtak.Results: In the present study there were (71) males and (14) females in the ratio of nearly 5:1. The males are 83.52% as compared females 16.47%.The commonest age group for stoma formation was in 21–30 years in either sex which is 23.52%. Numbers of males are higher in the age group of 51-60 years. The end ileostomy was made in 46 patients and loop ileostomy was in 27 patients. Oedema was seen maximally 19 patients of loop ileostomy. The other complications which are less common are retraction and ischemia of stomas. Four patients were died during treatment in this period in the present study.Conclusions: Intestinal stomas are commonly performed surgical procedure for intestinal diseases, to minimise or decrease the potential complications due to intestinal stoma meticulous attention and extreme care should be employed in preoperative and postoperative periods. Here we have provided an overview of the complications seen in formation of intestinal stomas, keeping these probable complications in mind, decision making and surgical technique continue to be remain the keys to successful stoma formation.
An ergonomic modification of the American position for laparoscopic cholecystectomy in a rural setting
Authors: Umman Philip , Menezes Clyde R. , Bosco Ashish , Menon Nandakumar
Published: July 2019

Laparoscopic cholecystectomy (LC) is the gold standard for the treatment of symptomatic gallstone disease. As a result of the significant investments in setting up a laparoscopy unit and training nursing staff in laparoscopic techniques, the cost of laparoscopic surgery is higher. However, the urban poor and rural population of India stand to benefit most from laparoscopy, owing to the shorter recovery times and reduced post-operative pain. The American and French positions have been described for laparoscopic cholecystectomy. Studies on ergonomics in laparoscopy deal mainly with issues related to the operating surgeon. There is not much literature on the issues faced by the team members during laparoscopy, especially in resource constrained settings. The authors propose a modification of the American position for LC, which enhances comfort and vision for the scrub nurse and also helps the surgeon guide the novice staff in LC.
A case report of eumycetoma in the thigh: an unusual presentation as a lump
Authors: Chitrambalam Tharun Ganapathy , Sekhar Sidhu , Panicker Koshy Mathew , Sundaraj Jeyakumar
Published: July 2019

Mycetoma is a chronic disease, which is endemic in tropical and subtropical countries. Mycetoma is a chronic subcutaneous infection caused by Actinomycetes or fungi. This infection results in a granulomatous inflammatory response in the deep dermis and subcutaneous tissue, which can extend to the underlying bone. Mycetoma is characterized by the formation of grains containing aggregates of the causative organisms that may be discharged onto the skin surface through multiple sinuses. Here we report an unusual presentation of eumycetoma in the thigh of a 41 year old male rural industrial worker hailing from South India.
Jejunal perforation secondary to trichobezoar (Rapunzel syndrome): a rare presentation
Authors: Saroj Jitendra Kumar , Ahmad Arshad , Kumar Pankaj , Verma Sandeep
Published: July 2019

Trichobezoar is a rare disorder. It usually occurs in young and adolescent females associated with some psychiatric illness. Trichobezoar usually accumulate in the GI tract and most commonly in stomach but it can migrate through the pylorus into the jejunum, ileum and colon. Once the bezoars extends from the stomach into the jejunum or further on, it is referred to as “Rapunzel syndrome”. Though initially asymptomatic but over a period of time it may cause gastric mucosal erosion, ulceration, and perforation of the stomach or the small intestine. If unrecognized, tichobezoar may present with intussusceptions, obstructive jaundice, protein-losing enteropathy, pancreatitis and even death. Small trichobezoar may be extracted by endoscopic fragmentation but bezoars like Rapunzel Syndrome, on the other hand, need open surgical removal. Counseling by a psychiatrist is an important part of management to prevent recurrence.
Jejunal atresia presenting as meconium cyst with polysplenia in a newborn: an extremely rare association
Authors: . Rashi , Basu Kalyani Saha , Biswas Samiran , Barman Shibsankar
Published: July 2019

Jejunal atresia (JA) presenting as meconium cyst with polysplenia is an extremely rare condition. We reported a case presenting with abdominal distension and feculent vomiting. Exploration revealed a type IV JA with dilated proximal segment presented as a large cyst filled with air and meconium. Polysplenia diagnosed incidentally.
Micropapillary variant of transitional cell carcinoma in a young adult: a rare case report
Authors: Barua Sasanka Kumar , Ghanghoria Ashish , Baruah Saumar Jyoti , P. Rajeev T. , Bagchi Puskal Kumar , Sarma Debanga , Phukan Mandeep
Published: July 2019

Micropapillary carcinoma is an uncommon variant of urothelial carcinoma with high metastatic potential. Usually seen in elderly individual, we herein report a case of 42 years old man presented with macroscopic hematuria for 1 month. Evaluation with CECT whole abdomen revealed irregularly marginated hyperattenuated mildly enhancing intraluminal mass lesions in right lateral wall and in floor of urinary bladder. No perivesical infiltration and no regional lymphadenopathy were detected. TURBT done and subsequent histopathological examination showed a high-grade transitional cell carcinoma with micropapillary variant. He was subjected to radical cystoprostatectomy with pelvic lymph node dissection. The pathological examination revealed a high-grade transitional cell carcinoma with micropapillary variant invading the perivesical adipose tissue. No tumor recurrence or metastasis was reported at the 18-months follow-up.
Open reduction and internal fixation of volar Barton’s fractures by polyaxial locking plates: a retrospective study
Authors: Murugesan Angatha Kumar , Govindasamy Rajesh , Ismail Patel Yahya
Published: July 2019

Background: A Barton’s fracture is a compression injury with a marginal shearing fracture of the distal radius. Conservative management of these fractures are highly unsuccessful with multiple complications. Locked plate and screw systems acts as single unit for fracture fixation, allows early mobilisation with good functional recovery.The objective of the study is to evaluate the functional and radiological outcome of volar Barton’s fractures treated with polyaxial locking plates.

Methods: Thirty six patients with volar Barton’s fractures, who underwent surgical treatment with polyaxial locking plate between June 2014 to June 2018, with a minimum one year of follow up. The fractures were classified according to Mehara’s classification and the outcome was evaluated using Pattee and Thompson criteria for outcome of wrist.

Results: We achieved 100 % union in all patients. Our results were excellent (61%), good (28%) and fair (11%). Our complications include superficial infection, finger stiffness, radiocarpal arthritis, extensor tendon rupture and Sudeck’s osteodystrophy.

Conclusions: Polyaxial locking plates restore articular congruity of the volar Barton’s fracturess and give best possible results with least complication rates, provided the technique is carefully performed.
The motor activity in acute cerebral stroke based on the Performance Oriented Mobility Assessment test modified by M. T inetti (1986), functional stress tests and screening assessment of visual-spatial disorders
Authors: Alekhin A. N. , Sakovsky I. V. , Kemstach V. V. , Pomnikov V. G. , Tarantseva V. M. , Dorofeyeva V. V.
Published: July 2019

Objective. The article presents the survey data of 80 patients in the acute period of cerebral stroke who were treated in the department of the primary vascular center. Design and methods. Upon recommendations of the motor activity, the patients with acute stroke were screened for the presence of neglect. The choice of motor activity was based on the Performance Oriented Mobility Assessment test in the modification of M. Tinetti (1986) and the results of functional stress tests. Results. There were no complications or falls at the hospital when adequate vegetative support and a high score at Performance Oriented Mobility Assessment in the modification of M. Tinetti (1986) were present, as well as in the absence of visual-spatial inability. The patients with the significant visual-spatial neglect showed higher risk of falls, even with adequate vegetative support and postural stability. Results. We demonstrated the possibility, as well as the prognostic value of the Performance Oriented Mobility Assessment in the modification of M. Tinetti (1986) and functional stress tests along with the assessment of visual-spatial neglect in planning the early motor rehabilitation of patients with cerebral stroke. In addition, we developed an algorithm for the motor rehabilitation planning.