bluuebunny/crossref_metadata_2025 huggingface dataset:
Mengungkap Hubungan Sikap Kerja Karyawan Terhadap Kinerja Melalui Variabel Mediasi Employee Engagement
Authors: Adila Adila , Pintauli Rolyana Ferinia
Published: June 2023

Tujuan dari penelitian ini untuk menganalisis berapa besar pengaruh sikap kerja terhadap kinerja secara parsial dan simultan. Metode kuantitatif dan desain korelasional menjadi dasar menganalisis data dengan menggunakan SEM-PLS sebagai perangkat untuk menghitung untuk menganalisis outer dan inner model. Jumlah responden adalah 73 orang dengan menggunakan sampel purposive sampling. Hasilnya 1). sikap kerja yaitu kerajinan karyawan berpengaruh substansial terhadap employee engagement; 2). Employee engagement yaitu karyawan merasa nyaman mengembangkan karir berpengaruh substansial terhadap kinerja; 3). Sikap kerja yaitu kerajinan karyawan berpengaruh substansial terhadap kinerja; 4). Sikap kerja berpengaruh moderat terhadap kinerja melalui employee engagement. Kebaruan penelitian ini adalah karyawan yang rajin (sikap kerja), kenyamanan mengembangkan karir (employee engagement), dan pimpinan mengapresiasi pekerjaan (kinerja) adalah tawaran alternatif untuk mengoptimalisasi kemampuan karyawan ditempat kerja.
Analisis Faktor-Faktor Yang Mempengaruhi Kemiskinan di Provinsi Jambi
Authors: Suripto Suripto , Angraini Monica Dyah
Published: June 2023

Kebijakan pemerintah daerah diharapkan dapat mengatasi masalah kemiskinan di daerahnya. Kebijakan pembangunan daerah ditujukan untuk mengatasi permasalahan kemiskinan karena kemiskinan merupakan permasalahan penting yang perlu dipecahkan untuk menunjang keberhasilan pembangunan ekonomi. Penelitian ini ditujukan untuk mengetahui factor-faktor yang mempengaruhi kemiskinan di Provinsi Jambi, sehingga hasil dari penelitian ini dapat digunakan sebagai acuan bagi pemerintah untuk mengambil kebijakan-kebijakan dalam upaya pembangunan dan kesejahteraan masyarakat Provinsi Jambi. Data penelitian menggunakan data sekunder yang didapatkan dari sumber Badan Pusat Statistik (BPS) tahun 2009 sampai dengan tahun 2019. Metode yang digunakan adalah studi kasus karena penelitian ini terdiri atas pengumpulan data-data yang menunjang dari satu peristiwa yang diangkat. Alat yang digunakan adalah statistik induktif dan regresi data panel. Hasil penelitian diperoleh bahwa variabel jumlah penduduk memiliki pengaruh positif dan tidak signifikan terhadap tingkat kemiskinan, variabel pengangguran berpengaruh negatif tidak signifikan terhadap kemiskinan, variabel pertumbuhan ekonomi berpengaruh negatif dan signifikan terhadap kemiskinan dan variabel pendidikan berpengaruh positif dan tidak signifikan terhadap kemiskinan di Provinsi Jambi tahun 2009-2019.
RP-HPLC method for estimation of miglitol and metformin hydrochloride in pharmaceutical formulation
Authors: Bhanu Teja Reddy Thumkuntla  , Manjunath Sooganna Yalagatti
Published: June 2023

A simple, rapid and sensitive RP-HPLC method was developed for the quantitative determination of metformin hydrochloride and miglitol in combined tablet dosage form. The chromatographic analysis was carried out on Phenomenex Gemini C18 (250 x 4.6 mm, 5 μm) with mobile phase containing methanol: TEA buffer (50:50 v/v). The flow rate of mobile phase was 1.0 mL/min and effluents were monitored at 272 nm. The retention times of miglitol and metformin hydrochloride were 2.121 min and 3.643 min, respectively. The proposed method was validated with respect to linearity, accuracy, precision, specificity and robustness.The method was found to simple, rapid and sensitive and was successfully applied to the estimation of metformin hydrochloride and miglitol in combined dosage form.
Comparison of Gravoply plate barcode embedding in Complete Denture Prosthesis (CDP) to lamination barcode embedding for forensic identification purposes
Authors: Basma Rosandi Prakosa  , Raden Aditya Wisnu Wardhana  , Annisa Putri  , Emy Khuironi  , Wahyu Agung Pramukti
Published: June 2023

Background: Mass disasters often occur in Indonesia, thus require the rapid identification of victims. Teeth can be one of the primary identifiers besides fingerprints and DNA. It includes dentures worn by the victim. The Denture Marking System is a technique for labeling dentures to prevent it being swapped to another. Labeling usually uses embedded barcode, made from laminated paper or gravoply plate. Purpose: To compare Gravoply plate barcode to lamination barcode embedded in prothese for forensic identification. Methods: The type of research is a true experimental study with a posttest-only control group design. The sample size used in this study is 20 CDP samples divided into two test groups, one is Gravoply plate barcode and another one is laminated photo paper barcode. Results: 10 sampels of gravoply plate barcode can be read correctly, meanwhile 6 of laminated photo paper barcode showed incorrect reading and only 4 of total samples had correct result. Chi-Square test obtained p value (p<0,05) means there is significant difference between two embedding techniques. Conclusion: Embedding barcode in denture protheses for forensic identification is better using Gravoply plate rather than laminated photo paper.
HUBUNGAN PROMOSI KESEHATAN DENGA KESTABILAN GULA DARAH DIABETES TIPE 2 CLUB DIABETES PENSIUNAN YAKES TELKOM JATIM BALI NUSRA
Authors: Chambali Achmad , Syarifah Has, Dwi Faqihatus
Published: June 2023

Promosi kesehatan menjadi tumpuan harapan keberhasilan peningkatan status kesehatan penderita diabetes melitus terutama dalam menjaga kestabilan kadar gula darah lansia. Tujuan penelitian ini untuk menganalisis hubungan promosi kesehatan dengan kestabilan gula darah diabetes tipe 2 Club Diabets Pensiunan Yakes Telkom Jatim Bali Nusra.

Desain penelitian adalah analitic correlational observasional dengan desain pra eksperimental semu. Populasi adalah seluruh peserta Club Diabets Pensiunan Yakes Telkom Jatim Bali Nusra sejumlah 59 orang. Jumlah sampel sebanyak 52 pasien diambil dengan random sampling. Variabel bebas penelitian ini adalah promosi kesehatan, sedangkan variabel terikat yaitu kestabilan gula darah diabetes tipe 2. Instrumen yang digunakan penelitian ini adalah lembar kuesioner tentang kuis PHBS dari promosi kesehatan dan lembar rekam medis tentang kestabilan gula darah diabetes tipe 2. Analisis menggunakan uji Chi-Square pada tingkat kepercayaan 95% (p<0,05).

Hasil menunjukkan bahwa promosi kesehatan pada penderita diabetes mellitus tipe 2 sebagian besar baik, yaitu 69,2% dan kadar gula darah sebagian besar normal yaitu 51,9%. Ada hubungan promosi kesehatan dengan kestabilan gula darah diabetes tipe 2 Club Diabets Pensiunan Yakes Telkom Jatim Bali Nusra dengan nilai p=0,000 < 0,05.

Promosi kesehatan perlu dilaksanakan secara kesinambungan guna meningkatkan manajemen diri penderita dalam mempertahankan kestabilan gula darah
THE RELATIONSHIP OF INDEPENDENT CURRICULUM LEARNING WITH TEACHERS' MENTAL HEALTH
Authors: Mulyaningsih Trisistu , Inayah Zufra
Published: June 2023

Enhancement prevalence mental disorders of the population age above 15 by 3.7% of 2013-2018 so _ around 12 million Indonesian people experience depression , mental health related elementary teachers usability _ technology and perceptions of the effectiveness of online learning in the COVID-19 era also contributed in enhancement prevalence the . Objective study For analyze learning curriculum independent with teacher mental health . Study done in a manner quantitative and is analytic observational with des ai n cross sectional . Population is teacher at YPI Darussalam 2 Cerme Gresik Vocational School with total sampling technique as many as 32 people . Instrument research , questionnaire The Mental Health Inventory-38 (MHI-38) . Analysis use test Kendall's tau-b on level trust 95%. Results analysis learning curriculum independent almost entirely fulfilled by 84.4% and teacher mental health almost all good by 78.1% with P value = 0.003 < α = 0.05. It means There is connection between learning curriculum independent with teacher mental health
PENGARUH BEBAN KERJA TERHADAP TEKANAN DARAH PADA GURU di SMK ASSA’ADAH BUNGAH GRESIK
Authors: Daryati Yenni Daryanti , Inayah, SKM., M.Kes Zufra
Published: June 2023

Beban kerja guru yang melebihi batas waktu normal, akan mempengaruhi kesehatan kerja seseorang. Beban kerja yang berlebih dapat menyebabkan stres yang berdampak peningkatan resistensi pembuluh darah perifer dan menstimulasi aktivitas sistem saraf simpatis, dan berakhir pada naiknya tekanan darah. Beban kerja guru menurut Permendikbud No. 15 tahun 2018 maksimal 40 jam per minggu meliputi : merancang pembelajaran, melaksanakan pembelajaran, menilai hasil pembelajaran, melatih dan membimbing peserta didik serta melakukan tugas tambahan. Tujuan dari penelitian ini untuk mengetahui pengaruh beban kerja terhadap tekanan darah pada guru di SMK Ass'adah Bungah Gresik. Metode dalam penelitian ini menggunakan  observasional analitik dengan pendekatan cross sectional. Teknik pengambilan sampel yang digunakan yaitu simple random sampling (sampel acak sederhana) dan penentuan besar sampel menggunakan rumus slovin dan didapatkan hasil 86 orang sebagai sampel dari jumlah populasi sebanyak 105 orang  dan menggunakan uji statistic regresi logistic biner. Hasil tabulasi silang antara beban kerja dan tekanan darah didapatkan hasil bahwa guru yang mempunyai beban kerja berlebih akan memiliki tekanan darah yang tinggi pula yakni  sebesar 70,8%. Hasil uji statistic didapatkan P Value = 0,000 (α = 0.05). Kesimpulan hasil penelitian menunjukkan adanya pengaruh beban kerja dengan tekanan darah pada guru di SMK Assa’adah Bungah Gresik.
ASUHAN KEPERAWATAN PENURUNAN NYERI PADA IBU POST OPERASI SECTIO CAESAREA DENGAN PENERAPAN FOOT MASSAGE DI RUMAH SAKIT MITRA PLUMBON TAHUN 2021
Authors: Pratiwi Liliek , Dzakiah Rz Alfiany , Fatimatuz Zahra Fetty , Maknun Johar , Ramahwati Novi , Yuniandani Sanni
Published: June 2023

Latar Belakang:Sectio Caesarea atau persalinan buatanmerupakan suatu pembedahan yang bertujuan untuk mengeluarkan janin lewat sayatan laparatomi sampai histerotomidi karenakan persalinan normal melalui vagina tidak memungkinkan atau beresiko kepada komplikasi medis lainnya. Pasien post operasi sering kali mengalami nyeri hebat meskipun tersedia obat-obatan analgesik yang efektif. Hal tersebut membutuhkan intervensi yang tepat untuk menurunkan tingkat nyeri ibu post Sectio Caesarea.

Tujuan Penelitian: untuk mengetahui adanya pengaruh terapi non farmakologi foot massage terhadap penurunan nyeri ibu postSectio Caesarea.Metode: menggunakan metode studi kepustakaan (Study Literatur Review) dengan mengambil data yang telah diterbitkan dari situs terpercaya baik penelitian Nasioal maupun Intrnasional.

Hasil: Berdasarkan hasil penelitian melalui literature rivew peneliti mendapatkan 12 jurnal penelitian, 6 jurnal Nasional, dan 6 jurnal Internasional, dengan hasil terdapat perbedaan durasi pemijatan, diantaranya ada yang menggunakan waktu selama 10-20 menit ada pula yang berkisaran antara 15-30 menit walaupun ada perbedaan pada waktu intervesi, namun dari 12 jurnal menunjukan adanya penurunan skala nyeri pada ibu postSectio Caesarea sebelum dan setelah dilakukan intervensi foot massage.

Kesimpulan: Berdasarkan hasil systematic Review yang telah dilakukan didapatkan bahwa terapi Foot Massage mampu mengalihkan toleransi nyeri dan ambang batas nyeri sehingga ibu lebih toleran terhadap nyeri yang dialaminya.

Saran: Bagi ibu post Sectio Caesarea yang mengalami masalah nyeri diharapkan mampu mengetahui penyebab terjadinya nyeri dan menerima pedidikan kesehatan tentang penurunan nyeri pada ibu post Sectio Caesarea dan terapi foot massage diharapkan menjadi alternative dalam mengatasi masalah nyeri pada ibu postSectio Caesarea.
PRE-PROCESSING DATA ON MULTICLASS CLASSIFICATION OF ANEMIA AND IRON DEFICIENCY WITH THE XGBOOST METHOD
Authors: Nurrahman Fathu , Wijayanto Hari , Wigena Aji Hamim , Nurjanah Nunung
Published: June 2023

Anemia and iron deficiency are health problems in Indonesia and globally. In Multiclass Classification, data problems often occur, such as missing data, too many variables, and unbalanced data. Then pre-processing data will be carried out using MissForest imputation, Boruta featuring selection, and SMOTE to help improve the performance of the classification model in predicting a particular class. After the data pre-processing process is carried out, classification modeling will be carried out using the XGBoost algorithm. It was found that when pre-processing the data could improve the performance of the model in predicting multiclass classification for cases of anemia and iron deficiency in women in Indonesia by 0.815 for the accuracy value and 0.9693 for the AUC value
TOTAL EDGE IRREGULAR LABELING FOR TRIANGULAR GRID GRAPHS AND RELATED GRAPHS
Authors: Huda Muhammad Nurul , Susanti Yeni
Published: June 2023

Let  be a graph with  and  are the set of its vertices and edges, respectively. Total edge irregular -labeling on  is a map from  to  satisfies for any two distinct edges have distinct weights. The minimum  for which the  satisfies the labeling is spoken as its strength of total edge irregular labeling, represented by . In this paper, we discuss the tes of triangular grid graphs, its spanning subgraphs, and Sierpiński gasket graphs.
GEOGRAPHICALLY WEIGHTED PANEL REGRESSION (GWPR) FOR COVID-19 CASE IN INDONESIA
Authors: Mar'ah Zakiyah , Sifriyani Sifriyani
Published: June 2023

Coronavirus disease 2019 (COVID-19) is a newly emerging infectious disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) which was declared a pandemic by the World Health Organization (WHO) on March 11th, 2020. The response to this ongoing pandemic requires extensive collaboration across the scientific community to contain its impact and limit further transmission. Modeling to see cause-and-effect relationships in an event usually uses the Multiple Linear Regression (Ordinary Least Square) method. But in the case of Covid-19, the spread of the virus occurred from one location to another, so there was an indication that there was a spatial effect on the incident. In this study, we did not only look at spatial perspective but also considered time series data, so the method used was Geographically Weighted Panel Regression (GWPR). This study modeled the number of positive cases of Covid-19 in 34 provinces in Indonesia that occurred from March 2020 to August 2021 and looked at what factors influenced the number of positive cases of Covid-19 in each province. GWPR was performed with the assumption of a Fixed Effect Model (FEM). The FEM assumption was used by considering that the conditions of each observation unit were different. Based on the results, the best GWPR model obtained was the GWPR model with a Fixed Gaussian Kernel. The predictor variables that influenced the number of positive cases of Covid-19 were different at each location and tent to cluster at certain locations.
MODEL ANALYSIS OF THE SPREAD OF COVID-19 WITH LOGISTIC GROWTH RECRUITMENT
Authors: Nainggolan Jonner
Published: June 2023

This paper to analyzes the COVID-19 model with the growth of the logistics recruitment rate. Based on the model determined, the non-endemic stability points, threshold, and endemic stability points are obtained. The nonendemic stability point is asymptotically stable if the spread of COVID-19 decreases and vice versa. If the spread of COVID-19 increases, then the endemic stability P1 is globally asymptotically stable. Based on numerical simulations, the greater the recruitment rate, then the greater the number of susceptible and vaccinated subpopulation individuals. The smaller the value of the contact rate between infected individuals and those who are still healthy, the lower the number of infected individuals and vice versa, while the number of recovered subpopulation individuals is increasing. The greater the rate of treatment, the lower the number of infected individuals.
PREMIUMS CALCULATION OF TERMINAL ILLNESS INSURANCE
Authors: Satyahadewi Neva , Retnani Hani Dwi , Perdana Hendra , Tamtama Ray , Aprizkiyandari Siti
Published: June 2023

One related type of critical illness insurance is Long Term Care (LTC) Insurance. This study discusses the calculation of LTC insurance premiums with an annuity as a rider benefit. The benefit is included the cost of insurance care when diagnosed with a critical illness with a terminal condition or death because of any reason. The types of critical illnesses used in this study are cancer, heart disease, stroke, and diabetes mellitus. The data used are in the form of Indonesia's  mortality table, and data on the prevalence of critical illness patients with terminal illness conditions. The net annual premium value in this study was obtained through the results of the multiple-state model determination of the transition probabilities of 10 states. The transition probability of an insured candidate is obtained from the prevalence of critical illness patients and the prevalence of mortality. Based on the case study, the amount of net annual premium that must be paid by an insured female aged  years in good health is  for the protection period and the payment period is  years. The cost of insurance premiums for the male insured is greater than for the female insured. The higher the interest rate used, the smaller the net single premium that must be paid. The younger the age when registering the policy, the smaller the premium that must be paid. The longer the coverage period, the greater the premium that must be paid. This result is expected to be a recommendation for the prospective insured to adjust the suitable premium.
CLUSTER FAST DOUBLE BOOTSTRAP APPROACH WITH RANDOM EFFECT SPATIAL MODELING
Authors: Ngabu Wigbertus , Fitriani Rahma , Pramoedyo Henny , Astuti Ani Budi
Published: June 2023

Panel data is a combination of cross-sectional and time series data. Spatial panel analysis is an analysis to obtain information based on observations affected by the space or location effects. The effect of location effects on spatial analysis is presented in the form of weighting. The use of panel data in spatial regression provides a number of advantages, however, the spatial dependence test and parameter estimators generated in the spatial regression of data panel will be inaccurate when applied to areas with a small number of spatial units. One method to overcome the problem of small spatial unit size is the bootstrap method. This study used the fast double bootstrap (FDB) method by modeling the poverty rate in the Flores islands. The data used in the study was sourced from the BPS NTT Province website. The results of Hausman test show that the right model is Random effect. The spatial dependence test concludes that there is a spatial dependence and the poverty modeling in the Flores islands tends to use the SAR model. SAR random effect model R2 shows the value of 77.38 percent and it does not meet the assumption of normality. Spatial Autoregressive Random effect model with the Fast Double Bootstrap approach is able to explain the diversity of poverty rate in the Flores Island by 99.83 percent and fulfilling the assumption of residual normality. The results of the analysis using the FDB approach on the spatial panel show better results than the common spatial panel.
Mediatization of library education
Authors:   the N. P. Ogarev National Research Mordovia State University, Galina Mihailovna Ageeva
Published: June 2023

The phenomenon of mediatization of modern domestic library education is comprehended. The tasks of mediatization are defined, the reasons that caused it are named. In the article meditation is analyzed as a reorientation of activities in line with the trends of the media industry and the information relaying technology at the level of library practice and library education. The media format of library activity is an indicator of its modernity, relevance, and openness to innovation. The directions of mediatization of education (modernization, communication, professionalization, gamification) are shown, digital communication tools (websites, blogs, social networks, instant messengers, video hosting, etc.) are characterized, which are the object of study in media education and provide the accumulation and broadcast of educational content in the media environment. Mediatization correlates with the digitalization of the educational process. The media competencies fixed by the professional standard for library and information activities (2022) are considered. The experience of their formation at the Mordovian University is reflected.
Поколенческий подход в определении вектора развития государственной молодежной политики
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture»,, Dmitry Albertovich Bragin , Elena Nicolaevna Lvova ,   federal state budget educational institution of higher education «Saint Petersburg State University of Culture»,
Published: June 2023

Considering the issues of self-realization of young people in modern socio-economic and information and communication conditions, the article pays special attention to the representatives of generation Z, whose specific features are predetermined by the intensity of the development of digitalization and the media environment. The authors of the article consider the generational approach as a relevant tool for creating effective programs and projects for the implementation of the state youth policy in accordance with the demands of the time. The theory of generations, considered in the article as a methodological basis, determines attention to the issues of intergenerational communications and innovative educational practices, their transformation and virtualization. The interpenetration of managerial and pedagogical aspects in the socio-cultural sphere noted in the article determines the need to clarify the directions for the development of state youth policy, in accordance with which the main processes of self-realization of the new generation and its integration into the overall picture of the sociocultural space are conducted. Outlining the prospects, the authors of the article put forward proposals for balancing the key areas of youth policy focused on generation Z.
Neuroaesthetics: science, art and digital culture of the XXIst century
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture»,, Anna Yur’evna Demshina
Published: June 2023

The article considers neuroaesthetics as an important direction in modern science, neural networks that are actively included in art and culture. The network as a metaphor for our society is becoming the basis for the humanists’ reflections on the features of modern digital culture, the tools of neuroaesthetics help scientists, physiologists, art critics, and culturologists to better understand the characteristics of a person. A few provisions of torii art have also been proven from the standpoint of the work of our brain in the framework of neuroscience. The possibilities of neuroaesthetics and neuroprogramming have become part of the life of a modern person, manifesting themselves both in the use of graph theory and in the modeling of various objects associated with cinema and art practice. An important point is the criticism of neuroaesthetics for trying to present its conclusions as universal, but as human history shows, it is impossible. A separate issue is the criticism of neural networks by a few creative people, for whom digital projects based on neuroaesthetics and neural networks are identified by competitors. On the other hand, for a few creative people, neural networks have become a valuable tool for creativity, the creation of interdisciplinary projects of humanistic significance. As history shows, modern technologies help us solve principal issues, but cannot completely replace a person. The development of neuroaesthetic science expands our knowledge about the visual perception of works of art and other qualities of a person and the culture he creates. Latest information about sensations will lead us to an understanding of perceptual aesthetic experiences.
Musical traditions of orthodox culture in the education of young people
Authors:   federal state budget educational institution of higher education «Saint Petersburg State University of Culture»,, Elena Yuryevna Mironova
Published: June 2023

In the article, the music traditions of Orthodox culture in the education of young people are characterized and subjected to socio-cultural analysis. Forming a significant part of the spiritual and moral basis of Russian society, Orthodox culture today has a significant potential in educating the value orientations of young people, the implementation of which takes place on the basis of traditions formed over many centuries: the formation of ideal ideas about a person’s personality, the presence of mentors of a certain range of moral qualities, the inextricable connection of traditions with the national cultural and social code. Also, the article reveals the contradictions that characterize the process of forming the value orientations of youth based on the traditions of Orthodox culture at the present stage.
Modern museum landscape of the Urals
Authors:   Ural Federal University named after the first President of Russia B. N. Yeltsin, Tatiana Borisovna Mikhailova
Published: June 2023

In the paper the stages of formation of modern museum landscape in the Urals are traced. Factors are shown that influenced the change and restructuring of museum network, creating of new (state and private) museums, museification of industrial heritage. The concepts of creating and structure of corporative museums, exhibition activity of popular, cultural and art centers are analyzed. The author pays attention to the fact that the expansion of borders of museum world was affected by the process of globalization, rethinking of the XX century events, actual museological tendencies, development of domestic tourism.
Main forms of cultural relations between Russia and China in the XVIII century
Authors:   Federal state budget institution of higher education «Russian State University for the Humanities», Dmitrii Vladimirovich Tsvetkov
Published: June 2023

Cultural relations with Orient have very important place in history and culture of Russia. Reasons of this are in geographical situation of our country. During hundreds of years, countries and people of Orient made large cultural influence into Russia. Although, Russian and Chinese relations are researched quiet fully, cultural relations and premises of their appearance were researched not fully. During this research we will try to disclose these premises and deduce most important periods of their foundation. Foundation of cultural relations between Russia and China had political and economic premises: exploration of Siberia and Far Orient by Russian people. In relation to these processes there was requirement to learn languages and cultures of people in these regions, including Chinese. With first Russian translators from Chinese and Manchu, there are first Russian translations of Chinese historical and philosophical texts appeared in Russia. These texts were used by researchers to write their scientific works. Another important aspect of foundation of Russian-Chinese cultural relations was in translation of Chinese Confucianistic philosophical books by Russian intellectuals of the XVIII century. Purpose of these translations was in spreading and popularization of Chinese traditional view of ideal person and policy. Thus, foundation of Russian-Chinese cultural relations had historical dependence, and in early period China made largest influence into Russia, this influence was realized through textual culture.
Изучение особенностей извлечения редкоземельных элементов из лекарственного растительного сырья в настои и отвары
Authors: Дьякова Нина Алексеевна
Published: June 2023

Цель исследования — изучение особенностей извлечения редкоземельных элементов из лекарственного растительного сырья в настои и отвары. В качестве объектов исследования использовали фармакопейные виды лекарственного растительного сырья: листья крапивы двудомной (Urtica dioica L.), листья подорожника большого (Plantago major L.), цветки пижмы обыкновенной (Tanacetum vulgare L.), цветки липы сердцевидной (Tilia cordata Mill.), траву пустырника пятилопастного (Leonurus quinquelobatus Gilib.), траву полыни горькой (Artemisia absinthium L.), траву тысячелистника обыкновенного (Achillea millefolium L.), траву горца птичьего (Polygonum aviculare L.), корни лопуха обыкновенного (Arctium lappa L.), корни одуванчика лекарственного (Taraxacum officinale F. H. Wigg). Микроэлементный состав образцов изучали масс-спектроскопическим методом после кислотно-микроволнового разложения. В наименьшей степени лантаноиды содержались в цветках растений (0,08 – 0,22 мкг/г). Наиболее высокий уровень концентрации лантаноидов отмечен в исследуемых корнях растений, а также в траве горца птичьего и листьях подорожника большого (1,20 – 2,41 мкг/г). Содержание лантаноидов в изготовленных из изучаемого ЛРС настоях и отварах варьировало от 0,0001 до 0,0168 мкг/мл. Относительная концентрация лантаноидов в рассчитанном минеральном комплексе изготовленных лекарственных растительных препаратов составляла не более 0,0005 %, а в большинстве случаев — менее 0,0001 %. Зависимости содержания лантаноидов в настоях и отварах от содержания их в лекарственных растениях показывают, что при возрастании концентрации всех определяемых элементов в сырье увеличивается их концентрация в водных извлечениях. Однако при возрастании содержания лантаноидов в растении эффективность их перехода в водные извлечения снижается.
Разработка и валидация методики количественного определения гефитиниба в липосомальной лекарственной форме
Authors: Бурдаев Николай Игоревич , Шпрах Зоя Сергеевна , Николаева Людмила Леонидовна , Игнатьева Елена Владимировна , Косенко Валентина Владимировна , Бунятян Наталья Дмитриевна
Published: June 2023

Рак легкого — одно из самых распространенных злокачественных новообразований, для лечения которого широко используют ингибиторы рецептора эпидермального фактора роста (EGFR). Гефитиниб — ингибитор тирозинкиназы EGFR, эффективность клинического применения которого ограничена медленной абсорбцией в желудочно-кишечном тракте при пероральном применении, невысокой и изменчивой биодоступностью. Цель настоящего исследования — разработка методики количественного определения ингибитора рецептора эпидермального фактора роста гефитиниба в липосомальной лекарственной форме, которая разработана для повышения его биодоступности и терапевтической эффективности. В работе использовали метод прямой УФ-спектрометрии. Валидацию разработанной методики проводили в соответствии с действующими рекомендациями. Показано, что компоненты липосомального бислоя не влияют на спектральные характеристики гефитиниба и не мешают его количественному определению, то есть методика специфична. Валидация подтвердила линейную зависимость величины аналитического сигнала от концентрации гефитиниба в растворе. В аналитическом диапазоне от 70 до 130 % от номинального содержания гефитиниба в единице лекарственной формы методика обеспечена приемлемой правильностью и прецизионностью, а полученные результаты не отягощены систематической ошибкой. Предел обнаружения и предел количественного определения, рассчитанные с использованием параметров линейной зависимости, составили 0,26 мг и 0,80 мг гефитиниба соответственно. Расширенная аналитическая область методики позволяет использовать ее для количественного определения и определения однородности дозирования гефитиниба в лиофилизированной липосомальной лекарственной форме.
Фармакокинетика потенциального противоэпилептического фармакологического вещества ГИЖ-298 у крыс
Authors: Грибакина Оксана Геннадьевна , Кравцова Оксана Юрьевна , Литвин Александр Алексеевич , Колыванов Геннадий Борисович , Бочков Павел Олегович , Дворянинов Дмитрий Александрович , Бойко Светлана Семеновна , Жердев Владимир Павлович
Published: June 2023

На крысах изучена фармакокинетика соединения ГИЖ-298 при разных путях введения. После однократного внутрижелудочного и внутривенного введения в дозе 60 мг/кг исследуемое вещество в плазме крови животных определялось на протяжении 4 ч. Период полувыведения ГИЖ-298 из плазмы крови составил 0,48 ч после внутривенного введения и 0,66 ч — после внутрижелудочного. Установлено, что изучаемое соединение распределялось по органам и тканям неравномерно. Тканевая доступность ГИЖ-298 в системе «печень — плазма крови» составила 9,98; для почек — 5,53; селезенки — 3,79; скелетных мышц — 1,72 и органа-мишени (головной мозг) — 0,92. Абсолютная биодоступность соединения ГИЖ-298 после однократного внутрижелудочного введения составила 64,5 %, что говорит о перспективе разработки пер-оральной лекарственной формы для этого фармакологического вещества.
Quality, hydrocyanic acid content and acceptability of cassava peels ensiled with brewers’ spent grains
Authors:   Department of Animal Science, University of Uyo. P.M.B.1017. Uyo, Nigeria., Unah U. L. , Inyang U. A. ,   Department of Animal Science, University of Uyo. P.M.B.1017. Uyo, Nigeria., Solomon I. P. ,   Department of Animal Science, University of Uyo. P.M.B.1017. Uyo, Nigeria.
Published: June 2023

In this study, the acceptability of 21-day-old cassava peels ensiled with spent brewer's grains was investigated along with its qualitative properties and hydrocyanic acid content. For the manufacture of silage diets, cassava peels (CPL) and brewers' wasted grain (BSG) were combined as follows: 100% CPL (Diet 1), 50% CPL + 50% BSG (Diet 2), and 40% CPL + 60% BSG (Diet 3). The pH of the silage ranged from 3.76 - 4.63. Diet 1 had a higher aroma of alcohol than the other silages, which were all typically alcoholic. The value of crude protein (CP) increased when more BSG was included. From the analysis, it was shown that the cyanide content of cassava peels reduced to 15.18 mg kg-1 when ensiled from 187.50 mg kg-1 of the unensiled cassava peels. This indicates that ensiling reduced the antinutritional factor present in the cassava peels. The result of acceptability trials showed that there was a significant difference (p < 0.05) in feed dry matter (DM) intake (ranged 311.0 – 514.5 g d-1) with diet 3 recording the highest significant (p < 0.05) value of 514.5 g d-1. Diet 3 showed good quality silage, enhanced crude protein composition and could support small ruminants during off periods as against sole feeding of cassava peels. Keywords: Cassava peels, brewers’ spent grains, silage, hydrocyanic acid.
L-type (Loaf) Cervical Secretion Crystallization Directionality Biomarker Study
Authors: Murcia Lora José María , Esparza Encina María Luisa , Reig Cristina , Martínez Martínez Oscar , Simoni Jennifer , Martínez Calvo María Ángeles , Alcázar Juan Luis
Published: June 2023

Background: Cervical discharge is considered a hydrogel, which is part liquid and part solid. Under physiological conditions, the characteristic “fern-leaf” arborization is proportional to the circulating estradiol concentration and maximal in the preovulatory phase. Crystallization of the cervical secretion is a process of dehydration with the arrangement of sodium and potassium chloride crystals around a main axis composed of mucin. L-type (Loaf) (L) is proportional to the circulating estradiol concentration and is higher in the Fertile Window (FW). Currently, most studies comparing the FW with cervical discharge include the biophysical fertile window (BFW) which is 6 days before the estimated day of ovulation (EDO). Methods: Samples were taken from the vulvovaginal region within the FW using the Creighton Model System for Fertility Care (CrMS). Optical images of the samples were digitized to perform a binarization, skeletonization, and crystallization directionality study of the scanned branches. These samples taken from the vulvovaginal secretion were not collected from the endocervix. They were recorded by the Vaginal Secretion Recording System (VDRS) using CrMS. The FW was taken into account from 6 days before the peak (P) day according to CrMS. A statistical study was performed by comparing vulvovaginal crystallization samples including –6 day EDO in FW. Results: Out of 29 samples, 58.6% deemed true positives, 34% were true negatives, 6.8% represented 2 false positives, and no cases were false negatives (p < 0.001). Conclusions: Our analysis of the statistical distribution of the branching angles of the crystallization of cervical secretions allowed us to detect a significant contribution of 90-degree frecuencies, indicating, the existence of an L-type pattern in the FW samples that we studied. The skeletonization of the studied images together with a FW indicator allowed us to identify this crystallization pattern. We therefore propose this feature detection mechanism as a novel biomarker of fertility.
Forensic Characterization and Genetic Portrait of the Gannan Tibetan Ethnic Group via 165 AI-SNP Loci
Authors: Cui Wei , Chen Man , Yao Hongbing , Yang Qing , Liu Liu , Bai Xiaole , Chen Ling , Zhu Bofeng
Published: June 2023

Background: The Tibetan group is one of the oldest Sino-Tibetan ethnic groups. The origin, migration as well as the genetic background of Tibetans have become the research hotspots in the field of forensic genetics. The use of ancestry informative markers (AIMs) allows the investigation of the genetic background of the Gannan Tibetan group. Methods: In this study, the 165 ancestry informative single nucleotide polymorphism (AI-SNP) loci included in the Precision ID Ancestry Panel were used to genotype 101 Gannan Tibetans using the Ion S5 XL system. The forensic statistical parameters of 165 AI-SNP in the Gannan Tibetan group were calculated. Population genetic analyses including Nei’s genetic distances, phylogenetic analyses, pairwise fixation index, principal component analyses and population ancestry composition analyses were also conducted to evaluate the genetic relationships between the Gannan Tibetan group and other reference populations. Results: Forensic parameters of the 165 AI-SNP loci indicated that not all of the SNPs showed high genetic polymorphisms in the Gannan Tibetan group. Population genetic analyses indicated that the Gannan Tibetan group had close genetic affinities with East Asian populations, especially with the groups residing in its neighboring geographical regions. Conclusions: The 165 AI-SNP loci in the Precision ID Ancestry Panel showed high ancestral prediction powers for different continental populations. When trying to predict the ancestral information of East Asian subpopulations using this panel, the prediction results are not particularly accurate. The 165 AI-SNP loci showed varying degrees of genetic polymorphisms in the Gannan Tibetan group, and the combined use of these loci could be an effective tool in the forensic individual identification and parentage testing of this group. The Gannan Tibetan group has close genetic affinities with East Asian populations compared with other reference populations, especially tighter genetic relationships with the groups residing in its neighboring geographical regions.
An Extended AROMAN Method for Cargo Bike Delivery Concept Selection
Authors:   Faculty of Transport Engineering, University of Pardubice, Pardubice, Czech Republic, Bošković Sara , Švadlenka Libor ,   Faculty of Transport Engineering, University of Pardubice, Pardubice, Czech Republic, Dobrodolac Momčilo ,   University of Belgrade, Faculty of Transport and Traffic Engineering, Belgrade, Serbia, Jovčić Stefan ,   Faculty of Transport Engineering, University of Pardubice, Pardubice, Czech Republic, Zanne Marina ,   Faculty of Maritime Studies and Transport, University of Ljubljana, Portorose, Slovenia
Published: June 2023

Nowadays, cargo bikes play a vital role in the last-mile delivery process. Parcel distribution by cargo bikes becomes a more accessible and ecologically friendly solution. This paper addresses the investment decision on the cargo bike delivery concept selection problem. We investigated a better solution in terms of whether the company needs to perform the delivery by investing in its fleet of cargo bikes or renting cargo bikes from a third party. The third solution is to combine those two alternatives. This case considers four criteria: cargo bike procurement cost, cargo bike maintenance cost, return on investment, and financial profitability. To solve this problem, we applied the extended alternative ranking order method accounting two-step normalization (AROMAN) method. The results compared with the MARCOS and ARAS methods confirmed that delivery concept 2 (i.e. renting cargo bikes from third-party providers) represented the best solution for the e-commerce company.
Smart and Sustainable Waste Tire Management: Decision-Making Challenges and Future Directions
Authors:   University of Belgrade, Faculty of Transport and Traffic Engineering, Belgrade, Serbia, Dabic-Miletic Svetlana , Simic Vladimir ,   University of Belgrade, Faculty of Transport and Traffic Engineering, Belgrade, Serbia
Published: June 2023

The vehicle number has grown significantly in recent decades, resulting in a significant increase in the number of waste tires globally. The environment and public health are seriously endangered by the growing amount of waste tires. As a result, considerable effort is being put into the search for viable alternatives for sustainable management. Even though numerous treatments for waste tires have already been tested and proved successful, their continued industrial implementation remains difficult in both everyday life and research efforts. Finding practical, cost-effective, and ecologically friendly ways to manage waste tires is one of the biggest environmental challenges of the 21st century. By focusing on smart tire waste management, this study examines some of the most important decision-making challenges that support social and environmental sustainability. The main topics of this research are the examination of certain fundamental problems and challenges, as well as some key management strategies for this environmentally unfavorable type of increasing waste. This comprehensive analysis not only identifies significant gaps but also establishes the foundation for addressing some of the most significant decision-making issues in waste tire management by providing recommendations for further research in this important and vulnerable area of academic and practical analysis.
Analyzing of using case method based on flipped classroom on student learning outcomes. Jurnal Penelitian Pendidikan IPA, 9(6), 4103–4108
Authors: Huda Ismul , Desriana Putri , Safrida Safrida , Nurmaliah Cut , Muhibbuddin Muhibbuddin
Published: June 2023

An important goal of learning system is to deliver instruction that can produce equal or better learning outcomes. To achieve this goal, the number of research has been conducted to address the issue of what antecedent variables can affect the student learning outcomes. One of the methods which can develop student learning outcomes is case method based on flipped classroom. This research was conducted to analyze student learning outcomes using case method based on flipped classroom. This research is the quasi-experimental research with posttest only control group design. There is the control class and the experimental class in this research with a little of case method vs a lot of case method design. The participants in this study were 82 biology students using the total sampling technique. Data were analyzed using ANOVA to analyze the student learning outcome using case method based on flipped classroom. The results of study using case method based on flipped classroom has significant effect on student learning outcomes with a significance value of p < 0.05 with F (6.59) = 3.97, p=.012. Thus, it can be concluded that the case method which is combine with flipped classroom gives the positive impact on student learning outcomes.
Occupational Essentialness During COVID-19 and Attitudes Towards Labor Migration
Authors: Allen William L , Fernández-Reino Mariña , Ruiz Isabel
Published: June 2023

Leading scholarship consistently shows citizens prefer high-skilled immigrants, with implications for theorizing immigration attitudes. Without contesting this, we argue it ignores a crucial aspect of occupations that transcends skills: their essentialness to core economic and social functions. Leveraging the COVID-19 pandemic as a shock that revealed some occupations’ pre-existing essential qualities, particularly those disproportionately comprising immigrant workers, we show how this feature matters for mass preferences on labor migration. Our evidence comes from a conjoint experiment fielded during 2021 in the UK, one of the worst-affected countries globally. Respondents are 22 percentage points more likely to admit immigrants working in essential over non-essential occupations—with nationalities at the lower end of a perceived ethnic hierarchy benefiting significantly more, and particularly among respondents likely to hold more prejudice against immigrants. Our study contributes new theorization about the drivers of immigration attitudes during and beyond crises, with implications for labor migration policymaking.
NILAI PENDIDIKAN DALAM RANDAI GRUP MAMBANG KAYO PEKANBARU
Authors: Tulzahra Fadilah
Published: June 2023

Randai adalah seni pertunjukan tradisional Minangkabau yang melibatkan tarian, musik, dan drama teater. Selain menjadi bagian tak terpisahkan dari budaya Minangkabau, Randai juga memiliki potensi sebagai sumber nilai pendidikan yang kaya. Artikel ini bertujuan untuk menjelaskan unsur kesenian Randai dan juga nilai pendidikan serta pentingnya mempertahankan warisan budaya ini sebagai aset pembelajaran. Metode ini menggunakan teknik observasi dan wawancara pada pendekatan kualitatif. Nilai-nilai pendidikan yang dimaksud adalah nilai kebersamaan, nilai disiplin, nilai kreativitas, nilai keberanian , nilai moral, nilai menghargai budaya, dan nilai rasa empati.
DIFFUSION OF INNOVATION IN FLOATING CAGE CAGES IN JERUK SARI VILLAGE, TIRTO DISTRICT, PEKALONGAN REGENCY
Authors: Nurhidayah Ika Amiliya
Published: June 2023

One area often affected by Pekalongan Regency's tidal floods is Jeruk Sari Village. The village, located on the border of the regency and Pekalongan City, is an area that once had a lot of potentials, both from natural wealth and demographic conditions. The tidal flood that hit the village made Jeruk Sari turn into an area that contrasted with the previous situation. Seeing this problem, the community did not remain silent and continued striving for a new idea to deal with the economic crisis. Finally, the concept was popularized in the form of floating cage cultivation in Jeruk Sari Village. This study aims to identify the diffusion process of floating cage cultivation innovation in Jeruk Sari Village based on the perspective of Rogers's innovation diffusion theory. The research method used is qualitative descriptive with data analysis in the form of case studies. The results showed how many residents were able to accept the floating cage innovation; some were even interested in conducting trials, some other residents were skeptical of the success of the floating cage innovation, and some were indifferent.