bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN AYAH DALAM ROLE ATTAINMENT IBU PADA PEMBERIAN MP-ASI BAYI DI POSYANDU AYAH
Authors: Probowati Ririn , Qomariyah Lailatul , Ratnawati Mamik
Published: April 2018

Pendahuluan :Role Attainment ibu dalam kompetensi pemberian  Makanan Pendamping Air Susu Ibu (MP-ASI) akan mempengaruhi pertumbuhan pada bayi. Pertumbuhan dan perkembangan bayi sangat membutuhkan keterlibatan ayah dalam pemberian MP-ASI. Pemberian MP-ASI memerlukan peran/dukungan ayah, tetapi pada kenyataannya banyak ayah yang kurang berperan hal tersebut dikarenakan faktor pekerjaan serta aktivitas ayah yang lainya. Penelitian ini bertujuan untuk mengetahui peran ayah dalam role attainment ibu pada pemberian MP-ASI bayi di posyandu ayah dusun petengan desa tambak rejo jombang. Metode :Desain penelitian ini menggunakan korelasional cross sectional.Populasi dalam penelitian ini adalah semua ayah dan ibu yang memiliki bayi 6-12 bulan di posyandu ayah desa Tambakrejo kabupaten Jombang sejumlah 40 orang. Besar sampel 40 orang  yang diambil menggunakan total sampling.Variabel independent peran ayah, variabel dependent role attainment ibu. Instrument untuk peran ayah dan role attainment ibu menggunakan kuisoner. Analisa data menggunakan uji chi square. Hasil :Hasil penelitian menunjukan bahwa sebagian besar (55%) ayah berperan, sebagian besar (57,5%) role attainment ibu tercapai. Hasil analisa menggunakan uji chi square didapatkan bahwa Ï = 0,001 < 0,05 yang artinya ada hubunganperan ayah dalam role attainment ibu pada pemberian MP-ASI bayi.Tingkat hubungan antar dua variable tersebut ditunjukan dengan  nilai korelasi 0,478 yang terletak antara 0,400-0,599 dengan tingkat hubungan sedang.Pembahasan  :Role Attainment pemberian MP-ASI dipengaruhi oleh faktor ibu, karena ibulah yang sangat berperan dalam mengatur konsumsi anak yang kemudian akan berpengaruh pada status gizi anak akan tetapi akan lebih baik lagi jika ayah turut mendukung pola pemberian MP-ASI pada bayi usia 6-12 bulan.
EFEKTIFITAS PEMBERIAN FAMILY PSYCHOEDUCATION (FPE) TERHADAP KEPATUHAN MINUM OBAT PENDERITA SKIZOFRENIA DI KOTA KEDIRI
Authors: Sari Dhita Kurnia , Wardani Lingga Kusuma
Published: April 2018

ABSTRACT THE EFFECTIVENESS OF FAMILY PSYCHOEDUCATION (FPE) ON DRUG SUBSTITUTION OF SKIZOFRENIA PATIENTS IN THE CITY OF KEDIRI Dhita Kurnia Sari 1, Lingga Kusuma Wardani 2 STIKes Surya Mitra Husada Kediri deeniasari88@gmail.com

Schizophrenia is one type of psychotic disorders that often experience relapse. About 33% of people with schizophrenia experience recurrence and about 12.1% re-experienced hospitalization. Discontinuation of drugs is a major cause of recurrence of schizophrenic patients. The family of schizophrenic patients is a very important variable in the recurrence of schizophrenic patients. Allegedly the biggest factor in its effect on adherence to taking the drug of schizophrenia is family factor. The purpose of this study is to determine the effectiveness of family psychoeducation therapy on adherence to taking the drug of schizophrenia patients.            The design used in this research is pre-experiment. The population in the study were all families of schizophrenic patients in Kediri. Sampling technique in this research is taken by Purposive Sampling. The independent variable is the provision of family psychoeducatin therapy and the dependent variable in this study is the adherence to taking the drug of schizophrenic patients. Data were collected by observation sheet, then analyzed using Mc Nemar test with significance level aÂ£ 0,05.          The results of the study of adherence to the treatment of schizophrenic patients before given the family psychoeducation of 20 respondents who did not obey 20 respondents (100%), whereas after given the family psychoeducation obedient 17 (85%) and disobedient 3 (15%), from the results of statistical tests with using Mc Nemar test obtained p value 0,000 <Î± 0.05 means there is influence of adherence to medication before and after given family psycoeducation.            Family knowledge and ability to cope with stressors while caring for family members with schizophrenia can create a comfortable and conducive environment that helps restore the client's condition and reduce and prevent noncompliance with schizophrenia medication.

Keywords: adherence, family psychoeducation, schizophrenia
Organizational citizenship behavior and job satisfaction among non- academic employees of national universities in the Eastern province of Sri Lanka.
Authors: Ummah Salfiya , Athambawa S.
Published: April 2018

The aim of the paper is to study the impact of job satisfaction on Organizational Citizenship Behavior (OCB) among the nonacademic employees of national universities in the Eastern province of Sri Lanka. This is an explanatory study among 260 nonacademic employees working in Universities, using a structured questionnaire based on simple random sampling method. It was found that job satisfaction is one of the factors for determining the Organizational Citizenship Behavior (OCB) and the relationship was shown to be significant. Findings of this research effort could enable organizations to re think or reshape their job satisfaction system in order to achieve their desired organizational goals.

Keywords: Job Satisfaction, Organizational Citizenship Behavior (OCB), Non-academic employee
Türkiye ve Üçüncü Yaş Turizmi
Authors: TUFAN İsmail , TAMER KÖSE Melike , AYAN F. Sıla
Published: April 2018

Turizm, tarihte
ayrıcalıklı kesimlerin sahip olduğu bir lüks olarak görülse de yakın tarihte
çeşitli sınıf ve kimliklerden kişilerin ulaşacabileceği bir hizmet sektörü
oluşturmuştur. Buna karşın küresel ve ulusal kapsamda demografik yaşlanmanın
farkına varamayan Türk turizm sektörü bu önemli alana gereken yatırımı
yönlendirememektedir. Türkiye’ye gelen yabancı turistlerin büyük kısmını
oluşturan 60 yaş ve üzeri hedef kitlenin gözden kaçırılması görece daha genç ve
ekonomik açıdan daha dezavantajlı kişilere hizmet veren her şey dahil modelini
daha popüler kılmıştır. Ancak bu model turizme katkı sağlama olasılığı daha
yüksek olan ve her şey dahil hizmet modelinin sağlayamayacağı kültürel
etkileşim ve öğrenme imkanı talep eden yaşlı turistlere hitap etmemektedir. Bu
eksikliğin giderilmesinin kalkınma adına büyük bir önem arz ettiği gibi
uluslararası tanınırlık ve prestij adına da önemli faydalar sağlayabileceği
sonucuna ulaşılmıştır.
Türk Eğitim Vakfı Bursu Verilecek Uygun Adayların AHP ve TOPSIS Yöntemi Kullanılarak Belirlenmesi: Mehmet Akif Ersoy Üniversitesi Eğitim Fakültesi Örneği
Authors: PENÇE İhsan , TARHAN Leyla , ÇETİNKAYA BOZKURT Özlem
Published: April 2018

Ülkemizde yükseköğrenim gören başarılı fakat
maddi yetersizlikler nedeniyle zorluklar yaşayan öğrencilere, eğitimlerini daha
rahat sürdürmelerine destek olmak amacıyla oluşturulan kurum ve kuruluşlar
bulunmaktadır. Burs başvuru ve değerlendirme işlemlerinin vakit alması,
zahmetli olması ve subjektif etkenler bulunması sebebiyle karar verme süreci
karar vericiler için zor olmaktadır. Bu çalışmada Mehmet Akif Ersoy
Üniversitesi Eğitim Fakültesine Türk Eğitim Vakfından burs almak için başvuruda
bulunan öğrencileri daha etkin değerlendirmek amacıyla çok kriterli karar verme
yöntemleri kullanılmıştır. Başvuruda bulunan 27 öğrenci arasından burs
verilecek öğrencilerin seçimi için AHP ve TOPSIS yöntemleri kullanılmış olup,
en uygun 3 aday göreli yakınlık değerlerine göre belirlenmiştir. Çok kriterli
karar verme yöntemleri sayesinde kurum ve kuruluşlar için sıkıntılı olan seçim
süreci daha kolay bir şekilde yapılabilmiştir. Elde edilen sonuçlar yöntemin
burs veren kurum ve kuruluşlar için uygulanabilirliğini göstermiş olup seçim
sürecinin online ortama aktarılması sağlanabilir.
Intravenous acetaminophen for postoperative supratentorial craniotomy pain: a prospective, randomized, double-blinded, placebo-controlled trial
Authors: Sivakumar Walavan , Jensen Michael , Martinez Julie , Tanana Michael , Duncan Nancy , Hoesch Robert , Riva-Cambrin Jay K. , Kilburg Craig , Ansari Safdar , House Paul A.
Published: April 2018

OBJECTIVE

Acute pain control after cranial surgery is challenging. Prior research has shown that patients experience inadequate pain control post-craniotomy. The use of oral medications is sometimes delayed because of postoperative nausea, and the use of narcotics can impair the evaluation of brain function and thus are used judiciously. Few nonnarcotic intravenous (IV) analgesics exist. The authors present the results of the first prospective study evaluating the use of IV acetaminophen in patients after elective craniotomy.

METHODS

The authors conducted a randomized, double-blinded, placebo-controlled investigation. Adults undergoing elective, supratentorial craniotomies between September 2013 and June 2015 were randomized into two groups. The experimental group received 1000 mg/100 ml IV acetaminophen every 8 hours for 48 hours. The placebo group received 100 ml of 0.9% normal saline on the same schedule. Both groups were also treated with a standardized pain control algorithm. The study was powered to detect a 30% difference in the primary outcome measures: narcotic consumption (morphine equivalents, ME) at 24 and 48 hours after surgery. Patient-reported pain scores immediately postoperatively and 48 hours after surgery were also recorded.

RESULTS

A total of 204 patients completed the trial. No significant differences were found in narcotic consumption between groups at either time point (in the treatment and placebo groups, respectively, at 24 hours: 84.3 ME [95% CI 70.2–98.4] and 85.5 ME [95% CI 73–97.9]; and at 48 hours: 123.5 ME [95% CI 102.9–144.2] and 134.2 ME [95% CI 112.1–156.3]). The difference in improvement in patient-reported pain scores between the treatment and placebo groups was significant (p < 0.001).

CONCLUSIONS

Patients who received postoperative IV acetaminophen after craniotomy did not have significantly decreased narcotic consumption but did experience significantly lower pain scores after surgery. The drug was well tolerated and safe in this patient population.

Clinical trial registration no.: NCT01948505 (clinicaltrials.gov)
Huge heterogeneity in survival in a subset of adult patients with resected, wild-type isocitrate dehydrogenase status, WHO grade II astrocytomas
Authors: Poulen Gaëtan , Gozé Catherine , Rigau Valérie , Duffau Hugues
Published: April 2018

OBJECTIVE

World Health Organization grade II gliomas are infiltrating tumors that inexorably progress to a higher grade of malignancy. However, the time to malignant transformation is quite unpredictable at the individual patient level. A wild-type isocitrate dehydrogenase (IDH-wt) molecular profile has been reported as a poor prognostic factor, with more rapid progression and a shorter survival compared with IDH-mutant tumors. Here, the oncological outcomes of a series of adult patients with IDH-wt, diffuse, WHO grade II astrocytomas (AII) who underwent resection without early adjuvant therapy were investigated.

METHODS

A retrospective review of patients extracted from a prospective database who underwent resection between 2007 and 2013 for histopathologically confirmed, IDH-wt, non–1p19q codeleted AII was performed. All patients had a minimum follow-up period of 2 years. Information regarding clinical, radiographic, and surgical results and survival were collected and analyzed.

RESULTS

Thirty-one consecutive patients (18 men and 13 women, median age 39.6 years) were included in this study. The preoperative median tumor volume was 54 cm3 (range 3.5–180 cm3). The median growth rate, measured as the velocity of diametric expansion, was 2.45 mm/year. The median residual volume after surgery was 4.2 cm3 (range 0–30 cm3) with a median volumetric extent of resection of 93.97% (8 patients had a total or supratotal resection). No patient experienced permanent neurological deficits after surgery, and all patients resumed a normal life. No immediate postoperative chemotherapy or radiation therapy was given. The median clinical follow-up duration from diagnosis was 74 months (range 27–157 months). In this follow-up period, 18 patients received delayed chemotherapy and/or radiotherapy for tumor progression. Five patients (16%) died at a median time from radiological diagnosis of 3.5 years (range 2.6–4.5 years). Survival from diagnosis was 77.27% at 5 years. None of the 21 patients with a long-term follow-up greater than 5 years have died. There were no significant differences between the clinical, radiological, or molecular characteristics of the survivors relative to the patients who died.

CONCLUSIONS

Huge heterogeneity in the survival data for a subset of 31 patients with resected IDH-wt AII tumors was observed. These findings suggest that IDH mutation status alone is not sufficient to predict risk of malignant transformation and survival at the individual level. Therefore, the therapeutic management of AII tumors, in particular the decision to administer early adjuvant chemotherapy and/or radiation therapy following surgery, should not solely rely on routine molecular markers.
Keyhole strategy aiming at minimizing hospital stay for surgical clipping of unruptured middle cerebral artery aneurysms
Authors: Mori Kentaro , Wada Kojiro , Otani Naoki , Tomiyama Arata , Toyooka Terushige , Takeuchi Satoru , Yamamoto Takuji , Nakao Yasuaki , Arai Hajime
Published: April 2018

OBJECTIVE

Aneurysms of the middle cerebral artery (MCA) are still most often treated by clipping through standard craniotomy, but a longer hospital stay is one of the main drawbacks of this treatment. The authors developed a pterional keyhole clipping strategy for unruptured MCA aneurysms with the intention of minimizing hospital stay. In this paper, they report on their experience with this approach and analyze the long-term neurological and radiological outcomes.

METHODS

A total of 160 relatively small unruptured MCA aneurysms (mean 6.4 mm) were clipped through the pterional keyhole approach (19–30 mm, mean 24.6 mm) in 149 patients (aged 34–79 years, mean 62 years). Neurological and cognitive function were examined by several scales, including the modified Rankin Scale (mRS) and Mini–Mental State Examination (MMSE). Patients’ level of depression was assessed using the Beck Depression Inventory and Hamilton Depression Scale. The state of clipping was assessed at 1 year and then every few years after the operation.

RESULTS

The mean duration of postoperative hospitalization was 2.3 ± 3.4 days; in 31.3% of the cases, the patients were discharged on the day after the operation (overnight hospital stay) and in 93.2% within 3 days. Of the patients younger than 60 years, 40.4% required only an overnight stay. Complete aneurysm neck clipping was confirmed in 157 cases (98.1%). None of the completely clipped aneurysms showed any recurrence during the mean follow-up period of 5.0 years. The mean length of clinical follow-up was 5.4 years. After 2 (1.3%) of the surgical procedures, the patients showed persistent neurological deficits, defined as mRS score 1, but the overall operative morbidity based on the International Study of Unruptured Intracranial Aneurysms (ISUIA) definition (mRS score ≥ 2 or MMSE score < 24) was 0% at the last examination. Depression scores were significantly improved after surgery, and in 85.6% of the cases the patients were satisfied with their cosmetic results.

CONCLUSIONS

Pterional keyhole clipping is less invasive than clipping via standard craniotomy, minimizes hospital stay, and achieves durable treatment for relatively small unruptured MCA aneurysms.
Low dose CT reconstruction via L1 norm dictionary learning using alternating minimization algorithm and balancing principle
Authors: Wu Junfeng , Dai Fang , Hu Gang , Mou Xuanqin
Published: April 2018

Excessive radiation exposure in computed tomography (CT) scans increases the chance of developing cancer and has become a major clinical concern. Recently, statistical iterative reconstruction (SIR) with l0-norm dictionary learning regularization has been developed to reconstruct CT images from the low dose and few-view dataset in order to reduce radiation dose. Nonetheless, the sparse regularization term adopted in this approach is l0-norm, which cannot guarantee the global convergence of the proposed algorithm. To address this problem, in this study we introduced the l1-norm dictionary learning penalty into SIR framework for low dose CT image reconstruction, and developed an alternating minimization algorithm to minimize the associated objective function, which transforms CT image reconstruction problem into a sparse coding subproblem and an image updating subproblem. During the image updating process, an efficient model function approach based on balancing principle is applied to choose the regularization parameters. The proposed alternating minimization algorithm was evaluated first using real projection data of a sheep lung CT perfusion and then using numerical simulation based on sheep lung CT image and chest image. Both visual assessment and quantitative comparison using terms of root mean square error (RMSE) and structural similarity (SSIM) index demonstrated that the new image reconstruction algorithm yielded similar performance with l0-norm dictionary learning penalty and outperformed the conventional filtered backprojection (FBP) and total variation (TV) minimization algorithms.
Effects of standardized quassinoid-rich Eurycoma longifolia extract in a rat model of osteoporosis due to testosterone deficiency: A densitometric, morphometric and biomechanical study
Authors: Jayusman Putri Ayu , Mohamed Isa Naina , Alias Ekram , Dom Sulaiman Md , Shuid Ahmad Nazrun
Published: April 2018

BACKGROUND:

Eurycoma longifolia (EL) is a well-known aphrodisiac herb for men. Recently, the crude extract of EL was reported to possess anti-osteoporotic activities.

OBJECTIVE:

This study aims to determine the bone protective effects of the standardized quassinoid-rich EL extract in testosterone-deficient rat model.

METHODS:

Ninety-six intact male Sprague-Dawley rats were randomized into baseline, sham, orchidectomized, and chemically castrated groups. Chemical castration was performed via subcutaneous injection of degarelix at 2 mg/kg. The orchidectomized and degarelix-induced rats were administered with vehicle, intramuscularly injected with testosterone once a week, or orally supplemented with EL extract at doses of 25 mg/kg, 50 mg/kg or 100 mg/kg daily for 10 weeks. Bone mass, microarchitecture and strength were analyzed by dual-energy x-ray absorptiometry (DEXA), micro-CT and three-point bending test.

RESULTS:

Whole body bone mineral density and femoral bone mineral content significantly increased in testosterone groups ( p <  0.05). Micro-CT analysis revealed that trabecular bone volume, number, separation and connectivity density were significantly improved by testosterone administration. However, the structural model index was only improved in degarelix group supplemented with 100 mg/kg EL extract ( P <  0.05). The improvement of cortical thickness by EL extract was similar to that of testosterone groups ( p <  0.05). Biomechanically, EL extract supplementation was able to improve stiffness, strain and modulus of elasticity in degarelix-induced groups, while stress parameter was significantly improved in orchidectomized groups ( p <  0.05).

CONCLUSION:

Quassinoid-rich EL extract enables to protect against bone loss due to testosterone deficiency. The protective effect on cortical thickness and biomechanical parameters is comparable to testosterone group.
Two Aviation Accident Investigation Questionnaires for Passenger and Crew Survival Factors and Injuries
Authors: Davies Jan M. , Wallace W. Angus , Colton Christopher L. , Yoo Kyung In , Maurino Martin
Published: April 2018

BACKGROUND: Review of injuries resulting from aircraft accidents and analysis of their mechanisms have proved helpful in generating and implementing survival-related improvements. Ideally, such information should be correlated with seat belt type and use, as well as any brace
position adopted. This information should be recorded and made publicly available to future researchers.METHODS: Members of IBRACE have developed two questionnaires to assist accident / cabin-safety investigators to record this information in an integrated consistent manner.RESULTS:
One questionnaire relates to the survivors and one to the deceased.DISCUSSION: IBRACE members hope that these questionnaires will assist the investigation of future aircraft accidents.Davies JM, Wallace WA, Colton CL, Yoo KI, Maurino M. Two aviation accident investigation
questionnaires for passenger and crew survival factors and injuries. Aerosp Med Hum Perform. 2018; 89(5):483–486.
Modelling Soil Water Content in a Tomato Field: Proximal Gamma Ray Spectroscopy and Soil–Crop System Models
Authors: Strati Virginia , Albéri Matteo , Anconelli Stefano , Baldoncini Marica , Bittelli Marco , Bottardi Carlo , Chiarelli Enrico , Fabbri Barbara , Guidi Vincenzo , Raptis Kassandra Giulia Cristina , Solimando Domenico , Tomei Fausto , Villani Giulia , Mantovani Fabio
Published: April 2018

Proximal soil sensors are taking hold in the understanding of soil hydrogeological processes involved in precision agriculture. In this context, permanently installed gamma ray spectroscopy stations represent one of the best space–time trade off methods at field scale. This study proved the feasibility and reliability of soil water content monitoring through a seven-month continuous acquisition of terrestrial gamma radiation in a tomato test field. By employing a 1 L sodium iodide detector placed at a height of 2.25 m, we investigated the gamma signal coming from an area having a ~25 m radius and from a depth of approximately 30 cm. Experimental values, inferred after a calibration measurement and corrected for the presence of biomass, were corroborated with gravimetric data acquired under different soil moisture conditions, giving an average absolute discrepancy of about 2%. A quantitative comparison was carried out with data simulated by AquaCrop, CRITeRIA, and IRRINET soil–crop system models. The different goodness of fit obtained in bare soil condition and during the vegetated period highlighted that CRITeRIA showed the best agreement with the experimental data over the entire data-taking period while, in presence of the tomato crop, IRRINET provided the best results.
Characterization of Sub-Monolayer Contaminants at the Regrowth Interface in GaN Nanowires Grown by Selective-Area Molecular Beam Epitaxy
Authors: Blanchard Paul , Brubaker Matt , Harvey Todd , Roshko Alexana , Sanford Norman , Weber Joel , Bertness Kris
Published: April 2018

While GaN nanowires (NWs) offer an attractive architecture for a variety of nanoscale optical, electronic, and mechanical devices, defects such as crystal polarity inversion domains (IDs) can limit device performance. Moreover, the formation of such defects during NW growth is not fully understood. In this study, we use transmission electron microscopy (TEM) and atom probe tomography (APT) to investigate the effects of sub-monolayer contamination at the regrowth interface in GaN NWs grown by selective-area molecular beam epitaxy (MBE). TEM energy dispersive X-ray spectroscopy (EDS) and APT independently identified Al and O contamination localized at the regrowth interface in two of the three growth runs examined. The Al and O concentrations were each estimated to be on the order of 11% of an ideal c-plane monolayer in the most severely contaminated case. The amount of contamination correlated with the number of crystal polarity inversion domain defects (IDs) across the growth runs. A growth run in which the pre-regrowth HF vapor etch step was replaced by HCl immersion showed the smallest quantity of O and no measurable Al. In addition, many of the NWs examined from the HCl-treated growth run turned out to be free of IDs. These results suggest that sub-monolayer contamination introduced during processing contributes to defect formation in MBE-grown GaN NWs.
Changes in Psychosocial Adjustment of Adolescent Girls in the Lessons of Physical Education
Authors: Klizas Šarūnas , Malinauskas Romualdas , Karanauskienė Diana , Senikienė Žibuoklė , Klizienė Irina
Published: April 2018

Objective. The aim of the present study was to establish the changes in psychosocial adjustment of adolescent girls in the modified lessons of physical education. Material and Methods. An experimental design was used in the study. The experimental group included 14- to 15-year-old adolescent girls (n=128), and the control group comprised adolescent girls of the same school and the same age (n=137). The girls of the experimental group participated in modified physical education lessons. Once a month, they had a theory class where they received knowledge on communication disorders among adolescents and ways of preventing them by means of physical activities. In practical classes, the girls of the experimental group had sports games (basketball, volleyball, and football), enhancing physical abilities, and Pilates exercises. For the estimation of the level of adolescents’ psychosocial adjustment and its components (self-esteem and domination), an adapted questionnaire developed by Rogers and Dymond was applied. An adapted questionnaire developed by Huebner was administered to measure students’ satisfaction with life. Results. The analysis of the data demonstrated that when comparing the psychosocial adjustment of the adolescent girls in the experimental group before and after the experiment, a significant differences in the score of the psychosocial adjustment scale was established (53.81±8.34 vs. 59.41±7.66, P<0.05). After the experiment, high life satisfaction was reported by 42.19% of the girls (P<0.05). Conclusions. After the educational experiment, the index of the psychosocial adjustment scale in the experimental group improved statistically significantly.
Effect of Chain Length Compatibility of Alcohols on Muscovite Flotation by Dodecyl Amine
Authors: Wang Li , Sun Ning , Liu Jiapeng , Tang Honghu , Liu Runqing , Han Haisheng , Sun Wei , Hu Yuehua
Published: April 2018

A portion of dodecyl amine (DDA) in a muscovite flotation system was replaced with alcohols with different carbon-chain lengths. These alcohols included octanol (OCT); decanol (DEC); dodecanol (DOD); and tetradecanol (TER). The muscovite adsorption behavior of the mixed DDA and alcohol systems were investigated through zeta potential; contact angle; and adsorption quantity tests. Single-mineral flotation tests showed that the muscovite-collecting power of the mixed DDA/alcohol (OCT, DEC, or DOD) system was stronger than that of the pure DDA system. The muscovite-collecting power of the collector systems decreased in the following order: DDA/DEC > DDA/OCT > DDA/DEC > DDA > DDA/TER. Zeta potential and contact angle analysis indicated that when combined with DDA; alcohols physically adsorbed on the surfaces of muscovite. This behavior improved the hydrophobicity of muscovite. Furthermore, adsorption analysis revealed that synergy between DDA and alcohol enhanced the adsorption of alcohol on muscovite. DDA has a dominant role in synergistic adsorption; whereas alcohol has a supporting role. Among all tested alcohols; DDA and DOD exhibit the highest synergetic adsorption effect because of their similar carbon-chain lengths. This similarity promotes the formation of a compact adsorption layer on the muscovite surface.
A Highly Selective and Strong Anti-Interference Host-Guest Complex as Fluorescent Probe for Detection of Amantadine by Indicator Displacement Assay
Authors: Zhu Linzhao , Zhao Zhiyong , Zhang Xiongzhi , Zhang Haijun , Liang Feng , Liu Simin
Published: April 2018

Amantadine (AMA) and its derivatives are illicit veterinary drugs that are hard to detect at very low concentrations. Developing a fast, simple and highly sensitive method for the detection of AMA is highly in demand. Here, we designed an anthracyclic compound (ABAM) that binds to a cucurbit[7]uril (CB[7]) host with a high association constant of up to 8.7 × 108 M−1. The host-guest complex was then used as a fluorescent probe for the detection of AMA. Competition by AMA for occupying the cavity of CB[7] allows ABAM to release from the CB[7]-ABAM complex, causing significant fluorescence quenching of ABAM (indicator displacement assay, IDA). The linear range of the method is from 0.000188 to 0.375 μg/mL, and the detection limit can be as low as 6.5 × 10−5 μg/mL (0.35 nM). Most importantly, due to the high binding affinity between CB[7] and ABAM, this fluorescence host-guest system shows great anti-interference capacity. Thus, we are able to accurately determine the concentration of AMA in various samples, including pharmaceutical formulations.
Phytotoxic and Antifungal Metabolites from Curvularia crepinii QTYC-1 Isolated from the Gut of Pantala flavescens
Authors: Yin Caiping , Jin Liping , Sun Feifei , Xu Xiao , Shao Mingwei , Zhang Yinglao
Published: April 2018

Four metabolites (1–4), including a new macrolide, O-demethylated-zeaenol (2), and three known compounds, zeaenol (1), adenosine (3), and ergosta-5,7,22-trien-3b-ol (4) were isolated and purified from Curvularia crepinii QTYC-1, a fungus residing in the gut of Pantala flavescens. The structures of isolated compounds were identified on the basis of extensive spectroscopic analysis and by comparison of the corresponding data with those reported in the literature previously. The new compound 2 showed good phytotoxic activity against Echinochloa crusgalli with an IC50 value of less than 5 µg/mL, which was comparable to that of positive 2,4-dichlorophenoxyacetic acid (2,4-D). Compound 1 exhibited moderate herbicidal activity against E. crusgalli with an IC50 value of 28.8 μg/mL. Furthermore, the new metabolite 2 was found to possess moderate antifungal activity against Valsa mali at the concentration of 100 µg/mL, with the inhibition rate of 50%. These results suggest that the new macrolide 2 and the known compound 1 have potential to be used as biocontrol agents in agriculture.
Chemical Synthesis and Functional Analysis of VarvA Cyclotide
Authors: Álvarez Claudio A. , Santana Paula A. , Luna Omar , Cárdenas Constanza , Albericio Fernando , Romero María S. , Guzmán Fanny
Published: April 2018

Cyclotides are circular peptides found in various plant families. A cyclized backbone, together with multiple disulfide bonds, confers the peptides’ exceptional stability against protease digestion and thermal denaturation. In addition, the features of these antimicrobial molecules make them suitable for use in animal farming, such as aquaculture. Fmoc solid phase peptide synthesis on 2-chlorotrityl chlorine (CTC) resin using the “tea-bag” approach was conducted to generate the VarvA cyclotide identified previously from Viola arvensis. MALDI-TOF mass spectrometry determined the correct peptide amino acid sequence and the cyclization sites-critical in this multicyclic compound. The cyclotide showed antimicrobial activity against various Gram-negative bacteria, including recurrent pathogens present in Chilean aquaculture. The highest antimicrobial activity was found to be against Flavobacterium psychrophilum. In addition, membrane blebbing on the bacterial surface after exposure to the cyclotide was visualized by SEM microscopy and the Sytox Green permeabilization assay showed the ability to disrupt the bacterial membrane. We postulate that this compound can be proposed for the control of fish farming infections.
Computational Prediction and Analysis of Associations between Small Molecules and Binding-Associated S-Nitrosylation Sites
Authors: Huang Guohua , Li Jincheng , Zhao Chenglin
Published: April 2018

Interactions between drugs and proteins occupy a central position during the process of drug discovery and development. Numerous methods have recently been developed for identifying drug–target interactions, but few have been devoted to finding interactions between post-translationally modified proteins and drugs. We presented a machine learning-based method for identifying associations between small molecules and binding-associated S-nitrosylated (SNO-) proteins. Namely, small molecules were encoded by molecular fingerprint, SNO-proteins were encoded by the information entropy-based method, and the random forest was used to train a classifier. Ten-fold and leave-one-out cross validations achieved, respectively, 0.7235 and 0.7490 of the area under a receiver operating characteristic curve. Computational analysis of similarity suggested that SNO-proteins associated with the same drug shared statistically significant similarity, and vice versa. This method and finding are useful to identify drug–SNO associations and further facilitate the discovery and development of SNO-associated drugs.
Multi-Response Extraction Optimization Based on Anti-Oxidative Activity and Quality Evaluation by Main Indicator Ingredients Coupled with Chemometric Analysis on Thymus quinquecostatus Celak
Authors: Chang Yan-Li , Shen Meng , Ren Xue-Yang , He Ting , Wang Le , Fan Shu-Sheng , Wang Xiu-Huan , Li Xiao , Wang Xiao-Ping , Chen Xiao-Yi , Sui Hong , She Gai-Mei
Published: April 2018

Thymus quinquecostatus Celak is a species of thyme in China and it used as condiment and herbal medicine for a long time. To set up the quality evaluation of T. quinquecostatus, the response surface methodology (RSM) based on its 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging activity was introduced to optimize the extraction condition, and the main indicator components were found through an UPLC-LTQ-Orbitrap MSn method. The ethanol concentration, solid-liquid ratio, and extraction time on optimum conditions were 42.32%, 1:17.51, and 1.8 h, respectively. 35 components having 12 phenolic acids and 23 flavonoids were unambiguously or tentatively identified both positive and negative modes to employ for the comprehensive analysis in the optimum anti-oxidative part. A simple, reliable, and sensitive HPLC method was performed for the multi-component quantitative analysis of T. quinquecostatus using six characteristic and principal phenolic acids and flavonoids as reference compounds. Furthermore, the chemometrics methods (principal components analysis (PCA) and hierarchical clustering analysis (HCA)) appraised the growing areas and harvest time of this herb closely relative to the quality-controlled. This study provided full-scale qualitative and quantitative information for the quality evaluation of T. quinquecostatus, which would be a valuable reference for further study and development of this herb and related laid the foundation of further study on its pharmacological efficacy.
Anti-Diabetic Effects of Acankoreagenin from the Leaves of Acanthopanax Gracilistylus Herb in RIN-m5F Cells via Suppression of NF-κB Activation
Authors: Lu Man-Xia , Yang Yang , Zou Qin-Peng , Luo Jiao , Zhang Bin-Bei , Liu Xiang-Qian , Hwang Eun-Hee
Published: April 2018

Diabetes mellitus is a chronic degenerative disease that causes long-term complications and represents a serious public health problem. In this manuscript, acankoreagenin isolated from the leaves of Acanthopanax gracilistylus (LAG) is thought to possess excellent anti-diabetic properties. In vitro, anti-diabetic activities were assessed based on the inhibitory activities with α-glucosidase (IC50 13.01 μM), α-amylase (IC50 30.81 μM), and PTP1B (IC50 16.39 μM). Acankoreagenin showed better anti-diabetic effects. Then, an investigation was performed to analyze the insulin secretion effects of the insulin-secreting cell line in RIN-m5F cells. It was found that acankoreagenin could increase the insulin release in RIN-m5F cells. It was also found that acankoreagenin reduced NO production, activity of caspase-3, and the reactive oxygen species levels in the cells injured by processing of cytokines. In western blotting, inactivation of NF-κB signaling was confirmed. Acankoreagenin (20 μM) showed a higher I-κBα expression and lower NF-κB expression than the control group and showed a better expression than the positive control L-NAME (1 mM) (p < 0.05). This study demonstrates the anti-diabetic effects of acankoreagenin in vitro and suggests acankoreagenin might offer therapeutic potential for treating diabetes mellitus.
Using Peptidomimetics and Constrained Peptides as Valuable Tools for Inhibiting Protein–Protein Interactions
Authors: Robertson Naomi S. , Spring David R.
Published: April 2018

Protein–protein interactions (PPIs) are tremendously important for the function of many biological processes. However, because of the structure of many protein–protein interfaces (flat, featureless and relatively large), they have largely been overlooked as potential drug targets. In this review, we highlight the current tools used to study the molecular recognition of PPIs through the use of different peptidomimetics, from small molecules and scaffolds to peptides. Then, we focus on constrained peptides, and in particular, ways to constrain α-helices through stapling using both one- and two-component techniques.
The Wine Tourism Experience in New Zealand: An Investigation of Chinese Visitors' Interest and Engagement
Authors: Fountain Joanna
Published: April 2018

This study explores Chinese visitors' interest in engaging in wine tourism during their time in New Zealand. Informed by existing empirical and conceptual research into the wine tourism experience, a survey of 203 Chinese visitors in New Zealand (short-term holidaymakers and students)
reveals that they have relatively limited interest in wine tourism overall, but a growing proportion of them are visiting wineries during their time in New Zealand. The main appeal of wineries for Chinese visitors is the opportunity to relax and enjoy the scenery, although learning about wine
and wine making, tasting wine, and hearing stories about wine are of interest also. This is the case particularly among the student sample, who show greater interest and engagement in wine tourism than the short-stay holidaymakers. Recognizing that the Chinese market is not homogeneous, and
that their needs may differ from other visitor segments, this article outlines opportunities to develop winery experiences and provide service and hospitality which best meets their needs.
The electrical conductivity of CNT/graphene composites: a new method for accelerating transmission function calculations
Authors: Glukhova Olga E , Shmygin Dmitriy S
Published: April 2018

We present a new universal method to accelerate calculations of transmission function and electrical conductance of 2D materials, the supercell of which may contain hundreds or thousands of atoms. The verification of the proposed method is carried out by exemplarily calculating the electrical characteristics of graphene and graphane films. For the first time, we calculated the transmission function and electrical conductance of pillared graphene, composite film of carbon nanotubes (CNTs)/graphene. The electrical conductance of different models of this material was calculated in two mutually perpendicular directions. Regularities in resistance values were found.
VEIKIANČIO VĖDINIMO ŠILUMOGRĄŽIO SU ŠILUMOS SIURBLIU EFEKTYVUMO TYRIMAS
Authors: Buikis Justas , Rimdžius Dovydas , Martinaitis Vytautas
Published: April 2018

Straipsnyje nagrinėjamas vėdinimo įrenginys (VĮ) su priešpriešinių srautų šilumokaičiu (PSŠ) bei integruotu šilumos siurbliu (SŠ), esantis Vilniaus Gedimino technikos universiteto (VGTU) 8 aukšte, Pastato energetinių ir mikroklimato sistemų (PEMS) laboratorijos patalpose. Tyrimo metu buvo išmatuoti charakteringi taškai reikalingi nustatyti PSŠ efektyvumui: įtekančio oro temperatūros, tiekiamo ir šalinimo oro srautai. Išmatuotos efektyvumui nustatyti reikalingos į ŠS kondensatorių įtekančio bei ištekančio oro temperatūros ir kompresoriaus suvartotas elektros energijos kiekis. Eksperimento metu išmatuoti duomenys buvo naudojami nustatant PSŠ šilumokaičio temperatūrinį efektyvumą. Kadangi ŠS efektyvumas COP ir viso VĮ įrenginio efektyvumas priklauso nuo į įrenginį įtekančio oro temperatūros t1 sudarytas efektyvumo priklausomybės nuo temperatūros kitimo grafikas. Gauti duomenys parodė, kad PSŠ temperatūrinis efektyvumas viso tyrimo metu kito nuo 86 % iki 90 %, o ŠS COP kito nuo 1,73 iki 2,88. Tuo tarpu viso įrenginio efektyvumas kito nuo 2,94 iki 4,60.
ADMINISTRACINIO PASTATO APRŪPINIMO ENERGIJA VARIANTŲ ANALIZĖ
Authors: Lašinskas Martynas , Žėkas Vygantas
Published: April 2018

Vis griežtėjantys Europos Sąjungos reikalavimai pastatų sektoriuje reikalauja efektyvesnių ir ekologiškesnių sprendimų aprūpinant pastatus energija, todėl būtina ieškoti geriausių aprūpinimo energija variantų juos įvertinant keliais kriterijais. Šiame tyrime nagrinėjamos šios administracinio pastato aprūpinimo energija sistemos: biokuro katilas, kondensacinis dujų katilas, šilumos siurbliai (gruntas-vanduo ir oras-vanduo), saulės elementai, saulės kolektoriai. Pastato poreikiai modeliuojami DesignBuilder modeliavimo programa, o aprūpinimo energija variantų modeliavimas atliekamas energyPRO modeliavimo programa. Siekiant nustatyti optimalų aprūpinimo energija variantą sistemos yra lyginamos energiniu ir ekologiniu požiūriais.
ADSORBCINĖS VĖSINIMO MAŠINOS SEZONINIO EFEKTYVUMO TYRIMAS
Authors: Motuzas Robertas , Šiupšinskas Giedrius
Published: April 2018

Straipsnyje analizuojamas adsorbinės vėsinimo mašinos darbas, vėsinimo sezonu. Sistema modeliuojama simuliacine
programa TRNSYS. Šio tyrimo tikslas yra nustatyti sistemos sezoninį efektyvumo koeficientą (COP). Straipsnyje
pateikiami 4 skirtingų sistemų simuliacijos rezultatai ir jų tarpusavio palyginimas. Pagrindinis įrenginys - adsorbcinė
mašina, kurios veikimas modeliuojamas pagal Lietuvos metereologinius duomenis. Kintantys sistemos parametrai yra:
vėsinimo apkrovos dydis, šilumos šaltinio galia, saulės kolektorių plotas, tiekiama ir grįžtama vėsinimo temperatūros.
ROTACINIŲ ŠILUMOKAIČIŲ OPTIMIZAVIMAS
Authors: Sokolnikas Ignas , Čiuprinskas Kęstutis
Published: April 2018

Šiame straipsnyje analizuojami rotaciniai šilumokaičiai naudojami vėdinimo sistemose šilumai atgauti. Trumpai aptariami skirtingi šilumokaičių tipai, jų charakteristikos. Straipsnyje aprašomi atlikti rotacinių šilumokaičių bandymai KomfoLab laboratorijoje, pateikiama metodika apskaičiuoti rotacinių šilumokaičių temperatūrinį efektyvumą ir slėgio nuostolius. Rezultatai gauti modeliuojat šilumokaičius su baigtinių tūrių programa ANSYS lyginami su rezultatais gautais laboratorinių tyrimų metu. Toliau šilumokaičiai su skirtingais parametrais analizuojami su programa ANSYS pagal užsibrėžtas ribas. Gauti rezultatai lyginami pritaikant gyvavimo ciklo analizę. Išanalizavus šilumokaičius su mažiausiais gyvavimo ciklo kaštais yra pateikiami optimalūs rotacinių šilumokaičių parametrai.
Depletion of Heavy Nitrogen in the Cold Gas of Star-forming Regions
Authors: Furuya Kenji , Aikawa Yuri
Published: April 2018

We investigate nitrogen-isotope fractionation in forming and evolving molecular clouds using gas-ice astrochemical simulations. We find that the bulk gas can become depleted in heavy nitrogen (15N) due to the formation of 15N-enriched ices. Around the chemical transition from atomic nitrogen to N2, N15N is selectively photodissociated, which results in the enrichment of 15N in atomic nitrogen. As 15N-enriched atomic nitrogen is converted to ammonia ice via grain surface reactions, the bulk gas is depleted in 15N. The level of 15N depletion in the bulk gas can be up to a factor of two compared to the elemental nitrogen-isotope ratio, depending on the photodesorption yield of ammonia ice. Once the nitrogen isotopes are differentially partitioned between gas and solids in a molecular cloud, the condition should remain in the later stages of star formation (e.g., prestellar core) as long as the sublimation of ammonia ice is inefficient. Our model suggests that all of the N-bearing molecules in the cold gas of star-forming regions can be depleted in 15N, which is at least qualitatively consistent with the observations toward prestellar core L1544. In our models, icy species show both 15N and deuterium fractionation. The fractionation pattern within ice mantles is different between 15N and deuterium, reflecting their fractionation mechanisms; while the concentration of deuterium almost monotonically increases from the lower layers of the ice mantles to the upper layers, the concentration of 15N reaches the maximum at a certain depth and declines toward the surface.
Color Dispersion as an Indicator of Stellar Population Complexity: Insights from the Pixel Color–Magnitude Diagrams of 32 Bright Galaxies in Abell 1139 and Abell 2589
Authors: Lee Joon Hyeop , Pak Mina , Lee Hye-Ran , Oh Sree
Published: April 2018

We investigate the properties of bright galaxies of various morphological types in Abell 1139 and Abell 2589, using pixel color–magnitude diagram (pCMD) analysis. The sample contains 32 galaxies brighter than M

r
 = −21.3 mag with spectroscopic redshifts, which are deeply imaged in the g and r bands using the MegaCam mounted on the Canada–France–Hawaii Telescope. After masking contaminants with two-step procedures, we examine how the detailed properties in the pCMDs depend on galaxy morphology and infrared color. The mean g − r color as a function of surface brightness (μ

r
) in the pCMD of a galaxy shows good performance in distinguishing between early- and late-type galaxies, but it is not perfect because of the similarity between elliptical galaxies and bulge-dominated spiral galaxies. On the other hand, the g − r color dispersion as a function of μ

r
works better. We find that the best set of parameters for galaxy classification is a combination of the minimum color dispersion at μ

r
 ≤ 21.2 mag arcsec−2 and the maximum color dispersion at 20.0 ≤ μ

r
 ≤ 21.0 mag arcsec−2; the latter reflects the complexity of stellar populations at the disk component in a typical spiral galaxy. Finally, the color dispersion measurements of an elliptical galaxy appear to be correlated with the Wide-field Infrared Survey Explorer infrared color ([4.6]–[12]). This indicates that the complexity of stellar populations in an elliptical galaxy is related to its recent star formation activities. From this observational evidence, we infer that gas-rich minor mergers or gas interactions may have usually occurred during the recent growth of massive elliptical galaxies.
From Karl Menger to Charles Menger? How Austrian economics (hardly) spread in France
Authors: Campagnolo Gilles
Published: April 2018

The father of the “Austrian” Marginalist revolution and founder of the so-called “Austrian School of economics”, Carl Menger, had a mixed reception during different periods of development of French economics. Somewhat welcomed in the early days, he was rather forgotten later on. Even his major works were not published in translation until recently. What is the reason for such a situation? Criticisms of classical political economy have to be understood in their French context. In comparison to other countries, this paper details the case of France, besides showing how later Austrians, such as Friedrich Hayek, found a limited audience. This comparative study of economic ideas in France must start with the reception of the views of the founder and the role and impact of adopting/adapting or rejecting his views by French scholars. What place did they find in French academia? From Carl Menger to a “Frenchified” Charles Menger, how was Austrian economic thought disseminated in France? This essay starts by recalling the Belle-Époque and an astonishing letter by Charles Rist for the Jubiläum of Menger, in which he deplored the lack of translation of the latter’s works. The Austrian School in France is then discussed as pure economics replaces political economy in the Interwar period, with the 1938 Paris Congress of “liberal thinkers,” as the Vienna Circle became known, also comparing issues in philosophy. The paper considers how Austrian theories of “pure science” were received in Paris from the Vienna of the 1900s, at a time of ”Crossroads,” to the present day, through the Postwar and Cold War, until a revival since the 1990s and a rethinking of economic ideas after 2008.