bluuebunny/crossref_metadata_2025 huggingface dataset:
Environmental effects of urban wind energy harvesting: a review
Authors: Tsionas Ioannis , Llaguno-Munitxa Maider , Stephan André
Published: January 2025

Transitioning to renewable energy resources is necessary to address the energy and climate crisis and to be in accordance with UN Sustainable Development Goals (SDGs) 7, 11 and 13. Urban wind energy harvesting is still emerging mainly with the use of small wind turbines. Given their implementation challenges, positive and negative effects need to be weighed to make informed policy decisions and regulations. This systematic review evaluates the macro- and micro-scale environmental effects related to implementing small urban wind turbines (SUWTs). Although publications exist on diverse aspects of SUWTs, a review that addresses the broad range of identified environmental effects of SUWT implementations has been lacking until now. This review shows that while the study of the SUWTs’ environmental effects can build on the effects associated with large wind turbines, there are also significant differences. Given the heterogeneity of urban conditions, the implementation of SUWTs requires detailed local environmental assessment to characterise accurately most environmental effects, notably the net life-cycle primary energy performance and associated GHG emissions, raw materials depletion, recycling, safety, noise, visual and light pollution, and effects on urban wildlife. Effects that require further investigation and which possibly raise regulatory or social acceptance issues are identified and discussed.
Policy relevance
Harvesting urban wind energy can yield multiple environmental, efficiency and resilience benefits. However, several research and policy gaps remain to be addressed before deploying small wind turbines in urban contexts. These include: the need to quantify the net environmental gains of SUWTs based on their performance and life-cycle assessment; the structural implications of deploying SUWTs on existing buildings; the effect of SUWTs on local air quality and microclimates; the potential health and safety risks to those who may pass by; the effects of SUWTs on ecosystems; and the combined effects of SUWTs on people (e.g. noise or light annoyance). Further research and regulation can help to minimise the negative impacts and ensure social acceptability.
MAPPING THE SOWING WINDOWS OF WHEAT IN LUDHIANA DISTRICT USING SENTINEL-2 SATELLITE IMAGES
Authors: Kumar Sumit , Singh Randhir , Sohal Jaskaran Singh , Singh Bhupinder , Hassan Syed Shabih , Singh Japjit , Singh Balpreet , R. Setia  , B. Pateriya
Published: January 2025

Yellow rust is a destructive disease that adversely impact the growth and production of wheat. Previous studies shown that the parts of Rupnagar district, the foothill district of Punjab, is the most severely affected area for yellow rust of wheat because climate conditions in this area are favourable for its growth. Therefore, a study was planned to demonstrate the potential of Sentinel-2 images in detecting the yellow rust of wheat at village level (Nangal Nikku and Dukli villages of Rupnagar District of Punjab). The time series Normalized Difference Vegetation Index (NDVI) values from 27 January, 2024 to 08 February, 2024 were extracted from Sentinel-2 images to distinguish the diseased from healthy crop in the two villages. Compared with the NDVI values of healthy wheat, a decrease in NDVI by 17.9 -19.4% was observed in the disease stressed crop during this period. The rule-based classification effectively identified the yellow rust areas of wheat in the two villages. These results showed that Sentinel-2 may be used for detection of diseased crop at village level and this may assist in taking the contributing to improved crop health and yield sustainability.
INNOVATIVE METHODS OF CHEMICAL SCIENCE COMMUNICATION: MAKING CHEMISTRY ACCESSIBLE TO ALL
Authors: Palit Sibsankar , Basu Saikat Kumar
Published: January 2025

Effective communication in chemical science is essential for enhancing public understanding and engagement with the subject, particularly given its significance in addressing contemporary global challenges. This study investigates innovative methods for communicating chemical science to diverse audiences, including students and the general public. By employing a mixed-methods approach that includes a literature review, bibliometric analysis, a survey, and expert interviews, the research identifies key challenges in chemistry education and communication. Findings indicate that the complexity of chemical concepts, insufficient hands-on experiences, and the abstract nature of the subject hinder comprehension. The study highlights the importance of using visual aids, real-world applications, and technology integration to make chemistry more accessible. Recommendations for improving communication strategies are provided, aiming to foster greater appreciation for chemistry and its relevance to everyday life.
ENHANCED THERMAL INSULATION PROPERTIES OF SILICA AEROGELS FOR ENERGY-EFFICIENT APPLICATIONS
Authors: Azhar Mohd
Published: January 2025

In the quest for advanced materials with superior thermal insulation properties, silica aerogels have emerged as a promising candidate due to their ultra-low density, high porosity, and low thermal conductivity. This study focuses on the enhancement of thermal insulation properties of silica aerogels for energy-efficient applications, particularly in building insulation and industrial processes. We employed a sol-gel process combined with ambient pressure drying (APD) to synthesize silica aerogels with tailored pore structures and reduced thermal conductivity. A series of silica aerogels were prepared by varying key synthesis parameters, including precursor concentration, aging time, and surface modification techniques. The resulting aerogels were characterized using scanning electron microscopy (SEM), nitrogen adsorption-desorption isotherms (BET analysis), and thermal conductivity measurements. The study revealed that the pore size distribution and surface area of the aerogels could be effectively controlled, leading to significant reductions in thermal conductivity. Notably, the optimized aerogels achieved a thermal conductivity as low as 0.015 W/m·K, making them among the most efficient thermal insulators reported to date. In addition to their exceptional thermal properties, the mechanical strength and hydrophobicity of the aerogels were also enhanced through surface modification with organosilanes, ensuring durability and performance in harsh environments. The potential applications of these enhanced silica aerogels were explored in the context of energy-efficient building insulation, where they demonstrated a substantial reduction in heat loss compared to conventional insulation materials. The findings of this study highlight the potential of silica aerogels as a key material for the development of energy-efficient technologies. The synthesis process employed is scalable and environmentally friendly, making it suitable for industrial production. Future work will focus on further improving the mechanical properties and exploring hybrid aerogel composites for multifunctional applications.
ASSESSMENT OF GROUNDWATER QUALITY FOR DRINKING PURPOSE IN KATHURA BLOCK OF SONIPAT DISTRICT, HARYANA
Authors: Kumar Anup , Sharma Shubham , O.P. Thakur
Published: January 2025

The present study area Kathura block is located in Sonipat district of Haryana state. The geo-coordinates of the 0 0 0 0 study area are latitudes 29.05 N to 29.24 N and longitudes 76.47 E to 76.67 E and covers an area of 196.03 sq. km. Geologically alluvium and geomorphologically alluvial plain are present. The main objective of the study was to assess groundwater quality for drinking purpose in the study area. In the study area twelve groundwater samples were collected in 250 ml double capped plastic bottles. Geo-coordinates of sample locations were noted with the help of mobile GPS. Chemical analysis of twelve groundwater samples were done using Tamilnadu Water Supply and Drainage (TWAD) Board,Chennai prepared Field Water Testing kit for twelve chemical parameters viz. pH, alkalinity, hardness, chloride, total dissolved solids (TDS), fluoride, iron, nitrite, nitrate, ammonia, phosphate and residual chlorine. Result of groundwater samples analyses were compared with BIS (IS 10500:2012) drinking water standards to know groundwater quality for drinking purpose. In the study area pH ranges 7 to 8, alkalinity 120 mg/l to 800 mg/l, hardness 140 mg/l to 1730 mg/l, chloride 50 mg/l to 500 mg/l, TDS 408 mg/l to 3060 mg/l, fluoride 0.5 mg/l to 5 mg/l, iron nil to 10 mg/l, ammonia nil to 2 mg/l, nitrite 0.2 mg/l to 0.5 mg/l, nitrate 45 mg/l to 100 mg/l, phosphate nil to 2 mg/l and residual chlorine nil to 1mg/l. The study is highly useful for planning and monitoring of groundwater for drinking purpose in the study area.
ZIRCON (RED OXIDE OF LEAD): A VALUABLE GEMSTONE FROM JAWAHARAT-I-TIS' A HAVING MEDICINAL POTENTIAL IN PERSPECTIVE OF UNANI MEDICINE
Authors: Khan Snober , Kalam Mohd. Afsahul , Ashraf Bisma , Uvais Mohammad , Ibrahim Toyiba , Naqqash Naureen
Published: January 2025

This comprehensive study is about a gemstone named as “Zircon”.The study involves Zircon's vernacular names, identification, origin, acquisition, actions, properties, and its minerology etc. Zircon is a luminous stone derived from the Arabic words "Zar" and "Gūn" means Golden-coloured. It is a lustrous stone which is obtained from burnt lead. Historically Zircon has been esteemed among ancient gemstones. Besides its ornamental uses, it is used in capsule form, tablet form, as ointment, and in Sitz bath with fat and extract of Plantago major in Unani system of medicine as antiflatulent, cardiac tonic, and is used in Phlegmatic diseases, Wound healing, Skin disorders etc. So this study has been compiled to describe its medicinal uses in perspective of Unani system of medicine in detail.
EFFICACY OF A TOPICAL DIMAD IN THE MANAGEMENT OF WAJAʹAL-RAKBA (KNEE OSTEOARTHRITIS): A CASE REPORT
Authors: Adnan Ali  , Mushtaque Ahmed Mohammed Sheeraz , Iqbal Muskan , Mansoor Nairah
Published: January 2025

Background- Osteoarthritis is a global condition causing abnormal joint biomechanics and delayed articular cartilage deterioration, affecting the knee and affecting approximately 250 million individuals. It is a leading cause of impairment in the aged due to diabetes. Traditional treatments include pain medication, exercise, heat and cold therapy, corticosteroid injections, and joint repair or replacement surgery. The Unani medical system offers three treatment methods. 'Ilaj bi'l Tadbir (Regimenal Therapy), 'Ilaj bi'l Taghdhiya (Dietotherapy), 'Ilaj bi'l Dawa (Pharmacotherapy), and 'Ilaj bi'l Yad (Surgery), each with its own restrictions. Objectives- Efficacy of a topical Dimad in the management of Waja-al-Rakba (knee Osteoarthritis) and provide safe, effective and feasibly available with no or minimum side effect. Methods- A 40-year old female with bilateral knee pain and stiffness, diagnosed six months ago, presented to the OPD of the Regional Research Institute of Unani Medicine, Srinagar. Despite receiving analgesics, anti-inflammatory drugs, and physical therapy, she continued to deteriorate. In this study, a Dimad or medicated paste is applied over the anterior part of the left knee for two weeks daily twice a day for at least 15-20 minutes and then washed-out area with lukewarm water. Result- The study found that topical Dimad formulation effectively treated knee joint symptoms and inflammation. The patient's VAS scores decreased from 9 to 1 by the 14th day, indicating a decrease in symptoms. The treatment was safe and bearable, and the patient's quality of life improved significantly. After treatment, there was a statistically significant decrease in mean VAS ratings from day 0 to day 14. Conclusion- The patient reported a significant improvement in pain, stiffness, and soreness, and a significant decrease in mean VAS ratings from day 0 to day 14 after treatment.
PERSPECTIVE ON THE STRATEGIC ROLE OF THE NAVAL FORCES
Authors: CUCINSCHI Alexandru-Lucian
Published: January 2025

Although over time each service has developed specific doctrines aimed at achieving decisive victory against the adversary, using only their own capabilities, this approach now seems no longer viable in the context of new technologies and the dependency of military forces on elements that are not entirely under their control, such as the cyber domain. Nonetheless, the military have demonstrated that they possess some advantages in terms of the strategic impact they have, not only within a conflict but also as a state policy. This is also the case for Naval Forces, which have proven over time to be an important means of advancing the interestsof nations that have developed a strong maritime consciousness. In the article, one can find illustrated the strategic role of each service, subsequently being detailed the strategic missions of Naval Forces and how the Romanian Naval Forces can address this challenge.
Carbon Storage Potential and Microenvironment Preference of Mangrove Species in the Coastal Barangays of Tangub City, Misamis Occidental, Philippines
Authors: M. Tampipi Maricar , B. Buala Judy Ella , E. Antopina Regine , Zaragoza-Magsayo Monaliza Joy
Published: January 2025

This study aims to evaluate the aboveground and belowground carbon storage capacity and microenvironment preferences of mangrove species in the selected coastal barangays of Tangub City, Misamis Occidental. The study utilized non-destructive sampling for estimating the mangrove carbon, while, soil samples for organic carbon (SOC) were collected manually. Four mangrove species were recorded namely; Avicennia alba, Dolichandrone spathacea, Rhizophora apiculata, and Sonneratia alba. Results revealed that in Barangay Mantic, A. alba displayed the highest mean accumulated carbon value of 1.75 ± 0.30 Mg C ha-1. Overall, the three coastal barangays of Tangub City recorded an average total carbon of 360.72 Mg C ha-1, with soil having the highest carbon content (222.15 Mg C ha-1), followed by aboveground C (trunk) (107.29 Mg C ha-1) and belowground C (root) (31.28 Mg C ha-1). In terms of environmental factors, R. apiculata is associated with high relative humidity while, S. alba tolerated high water salinity, D. spathacea prefer area with higher air temperature, and A. alba is link with high water and soil temperature and pH levels. In general, mangrove ecosystem in the coastal areas of Tangub City stores significant amount of carbon in its various pools. Hence, it is imperative to implement conservation measures focusing on mangrove protection, zonation and sustainability in order to enhance carbon accumulation of these mangrove species.
Strategies for effective management of crop residues
Authors: Sarkar Arindam
Published: January 2025

Managing crop residue poses a growing challenge for the sustainable advancement of Indian agricultural science and environmental preservation, particularly in the Indo-Gangetic plains. Agricultural communities require education on the detrimental effects of burning crop residues in fields and the importance of integrating crop residues into the soil to conserve sustainable agricultural productivity and reduce production costs through alternative practices. Effective collection and management of crop residues are essential for utilizing it as a soil amendment, substrate for mushroom cultivation, incorporation into fields, bio-energy fuel, biochar production, and more. Crop residues can serve as livestock feed, fuel, industrial raw materials, compost ingredients, etc., holding significant economic value. Resource-conserving technologies such as zero-tillage, happy seeder utilization, bed planting, and polyculture, coupled with innovative residue management practices, community involvement, and support from governmental and non-governmental organizations, offer promising alternatives to energy-intensive and input-dependent farming methods.
Exploring the Socio-economic Dimensions of Rural Tourism and Community-based Conservation: A Case Study of Manas National Park, Assam, India
Authors: Bharadwaj Nabanita
Published: January 2025

This study explores into the intricate relationship between rural tourism, community-based conservation, and socio-economic dynamics, using the renowned Manas National Park in Assam, India, as a case study. Manas National Park stands as a testament to the potential synergy between conservation efforts and rural development through tourism. This paper explores how community involvement in conservation initiatives has not only preserved the natural biodiversity of the park but also fostered socio-economic upliftment in the surrounding rural areas. Through qualitative analysis, this research investigates the impact of tourism on local communities, examining aspects such as income generation, employment opportunities, cultural preservation, and infrastructure development. It explores the challenges and opportunities associated with sustainable tourism practices, emphasizing the need for balanced development that prioritizes both environmental conservation and community welfare. Insights gleaned from this case study can inform policymakers, conservationists, and local stakeholders on effective strategies for leveraging rural tourism as a catalyst for sustainable development and biodiversity conservation in similar contexts worldwide.
Dry Flower Technology: A Profitable Venture to Empower Women
Authors: Mir Saima Rashid
Published: January 2025

The demand for dried flower-based products is steadily rising in today’s eco-aware era owing to their outstanding characteristics, including unwavering quality, accessibility, sustainability, and compatibility for preparing numerous value-added products throughout the year. Various drying techniques can be employed to preserve different flowers, foliage, leaves, and other botanicals for use as decoration and ornamentation. Dehydrated flowers, foliage, seeds, and other products constitute India’s dry flower industry. Suitable drying techniques can be applied to almost any sort of flower, including leaves and other botanicals. The process of drying is a crucial factor in determining the quality of dried flowers, in addition to flower structure and collection time. Air drying, press drying, desiccant drying, microwave oven drying, hot air oven drying, glycerin drying, and leaf vein clearing are some of the different processes involved in the production of dried and appealing plant material. The flowers dried using the aforementioned methods can be used to create a variety of aesthetically important items, thus creating employment opportunities, especially for rural women and housewives.
Bio-efficacy of Different Fungal Bio-control Agents against the Root-knot nematode (Meloidogyne incognita) Inciting Tomato (Lycopersicon esculentum Mill.)
Authors: Abhi Ramavath , Sharma M.K. , Baheti B.L. , Manisha  , Jain Devendra , Trivedi Amit , Kaushik M.K. , Sharma H.K.
Published: January 2025

The present investigation was conducted under cage house condition for the management of root-knot nematode (RKN) inciting tomato with seven treatments including untreated control and four replications. Results revealed that all the treatments (i.e., Trichoderma harzianum, T. viride, Purpureocillium lilacinum, Metarhizium anisopliae, and Beauveria bassiana were used as soil application (SA) at 5 g/kg soil and seedling treatment (ST) at 5 g/l of water) were found significantly superior over an untreated control in increasing biometric parameters and reducing the RKN multiplication in plant and soil at termination. However, soil application at 5 g/kg soil and seedling treatment at 5 g/l of water with T. harzianum was found to be more effective in reducing RKN population and maximum biometric parameters of tomato followed by T. viride and P. lilacinum.
Enhanced Carbon-Based Nanomaterials for Superior Environmental Contaminant Separation
Authors: L. Kamble Varsha
Published: January 2025

Nanomaterials provide a unique way for the separation of contaminants from the environment by their large surface area, chemical modification capacity, and ease of regeneration. These properties make nanomaterials highly effective in removing pollutants from water and air, offering a promising solution for addressing environmental pollution. Additionally, their small size allows for easy dispersion and penetration into contaminated areas for thorough removal of contaminants. They have a lot of surface area, can be recycled, and are easy to desorb metal ions from while still being able to absorb them. This makes them easier to chemically change and recycle, which is why they are often used for cleanup. Furthermore, carbon nanoparticles may be easily mixed with other nanomaterials and functionalized, resulting in a multifunctional nano adsorbent. For remediation, nanomaterials primarily rely on the use of various methods such as adsorption, chemical modification, and filtration. Additionally, carbon nanoparticles have shown promising results in the removal of organic pollutants due to their high adsorption capacity and efficiency. By combining different nanomaterials, researchers can enhance the remediation process by targeting a wider range of contaminants. We have discussed current advances and the uses of carbon nano composites in the treatment of heavy metal-contaminated environments, as well as their use in environmental remediation, in this article. Carbon nano composites have shown great potential in removing heavy metals from contaminated environments due to their high surface area and reactivity. Additionally, their versatility in being combined with other nanomaterials allows for tailored solutions to specific remediation challenges.
Effect of Organic Nutrient Management Practices on Yield and Quality of Onion
Authors: Meena Rajesh , Singh Virendra , Kaushik R.A. , Sharma S.K. , Jain H.K. , Bunker R.N.
Published: January 2025

This investigation was conducted at Sericulture Farm, Department of Horticulture, Rajasthan College of Agriculture, MPUAT-Udaipur (Raj.) during Rabi season 2020-21 and 2021-22. The experiment comprised of 12 treatments with three replications were conducted over a two-year period, specifically from 2020-21 to 2021-22. Among the various organic treatments, T7 (50% of RDN through FYM + 50% of RDN through Neem cake + Panchagavya spray @ 3% + Vermiwash spray @ 5% at 30, 50 & 70 DAT + Jeevamrut @ 500 L ha-1 six times at 20 days intervals) was superior in respect to neck diameter at harvest (0.89 & 0.93 cm), diameter of bulb (5.43 & 5.81 cm), Average bulb weight (68.09 & 70.02 g), total soluble solid (16.77 & 17.03 %), pungency (5.95 & 6.24 µmol/g), bulb shape index (0.86 & 0.87) and dry matter content (15.70 & 15.91 %) content as compared to other treatments.
Influence of varietal screening on major sucking insect - pests of soybean
Authors: Parmar Devesh , Babu S. Ramesh , M.K. Mahla  , Saharan Vinod , Jain Devendra , M.L. Ojha
Published: January 2025

To find out the resistant varieties of soybean major sucking insect-pests for Southern Rajasthan. Study Design: Field trial: Randomized Block Design. Palace and Duration of investigation: The study was conducted at Rajasthan College of Agriculture, Udaipur during Kharif 2022 and 2023. 5 plants were randomly selected from each plot. The observations on the number of nymph and adults of whiteflies and jassids per 3 leaves were observed. The highest whiteflypopulation was recorded in JS 20-116 variety (5.47 and 4.78 whiteflies/ 3 leaves). The highest population of jassids was recorded in JS 20-116 variety (3.23 and 3.04 jassids/ 3 leaves) during Kharif 2022 and 2023, respectively. The varieties JS 20-34, JS 20-98 and JS 21-72 showed high resistance to whitefly and jassid during both years of observation. Varieties like RVS 2011-10, RKS-113, and RKS-45 were moderately resistant. However, varieties such as RKS-18, JS 97-52, JS-335, RSC 10-46, NRC-152, and JS 20-116 were found to be less resistant against these pests.
Pharmacology, Pharmacokinetics and Future Prospective of Indomethacin
Authors: Anshul Mehta  , Vikas Budhwar  , Manjusha Chaudhary
Published: January 2025

Indomethacin, categorized as a non-steroidal anti-inflammatory drug (NSAID) within the indoleacetic acid class, is widely recognized for its potent analgesic, anti-inflammatory, and antipyretic properties. As a non-selective inhibitor of cyclooxygenase (COX), it effectively hinders prostaglandin synthesis, providing relief from pain and inflammation. Indomethacin finds common application in treating various inflammatory conditions such as rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis. Despite its efficacy, the use of indomethacin is associated with potential adverse effects, particularly on the gastrointestinal tract, necessitating careful consideration of its risk-benefit profile in clinical settings. Ongoing research endeavors seek to explore its role in innovative therapeutic approaches and enhance its safety profile. A comprehensive understanding of the pharmacological characteristics of indomethacin is crucial for healthcare providers to make well-informed decisions regarding its use across diverse patient populations.
A Hunyadi-történet lepoglavai szála a 19. században
Authors: Fabó Edit
Published: January 2025

The figure of János Corvin interested the public of the time at least as much – if not
more – than it does today. This study describes how the interest in the resting place
of János Corvin and his son Kristóf in Lepoglava was reflected in the press and in academic life. Thanks to the news and reports circulating, attention was focused on the
royal heir who had been overshadowed by his father, the legendary King Matthias, and
whose development was mainly hindered by the Hungarian nobility of the Matthias
era. The historical significance of János Corvin was more appreciated in the region of
Bosnia and Herzegovina, especially in the national historical consciousness that was
awakening in the 19th century.
However, leading Hungarian scholars at the forefront of the most uptodate scientific
knowledge of the period started to trace the Hunyadi descendants. In addition, many
of them had credible information, but it did not become part of the literature they authored, and had it not been for a determined biographer, the information would have
been consigned to oblivion. Furthermore, the sad and well-known fact that there are
irreplaceable lacunae in the Hungarian archives due to the various war damages is a
grim testimony to the research. Although there were loose ends left to be tied up in the
19th-century Lepoglava grave openings, persistent investigation has yielded a result.
Associations of social isolation with sociodemographic aspects and health indicators in Brazilian middle-aged and older adults: ELSI-Brazil
Authors: Sandy Paulo Afonso , Borim Flávia Silva Arbex , Assumpção Daniela de , Neri Anita Liberalesso
Published: January 2025

Objectives: To investigate the prevalence of social isolation and its associations with sociodemographic and health indicators in Brazilian middle-aged and older adults recruited from households. Methods: A cross-sectional study of baseline data (2015–2016) of 7886 Brazilian adults aged 50 years and older from the Brazilian Longitudinal Study of Aging (ELSI-Brazil) was conducted. Social isolation was the dependent variable, as defined by living arrangement, frequency of contact with children, relatives, and friends, and degree of participation in social activities within the community. The independent variables were sociodemographic aspects, healthrelated behaviors, and health status. Associations between social isolation and independent variables were estimated using Poisson regression analysis. Results: The prevalence ratio (PR) of high level of social isolation was 23.13%. Significant positive associations were observed between high level of social isolation and male sex (PR 1.27; 95%CI 1.16–1.40); being 70 to 79 years old (PR 1.22; 95%CI 1.07–1.39) or 80 years or older (PR 1.56; 95%CI 1.32–1.85); having no formal education (PR 3.15; 95%CI 2.69–3.68) or having a maximum of 4 years (PR 2.11; 95%CI 1.82–2.46) or 5 to 8 years of formal education (PR 1.54; 95%CI 1.30–1.84); fair self-rated health (PR 1.25; 95%CI 1.12–1.39); depressive symptoms (PR 1.22; 95%CI 1.07–1.40); and poor-quality diet (PR 1.37; 95%CI 1.19–1.58). Fair sleep quality was negatively associated with social isolation (PR 0.87; 95%CI 0.78–0.98). Conclusions: The group most at risk for social isolation comprises men, aged 70 or older, with low educational attainment, fair self-rated health, and an unhealthy diet. Future research should use longitudinal study designs to investigate causal relationships and develop interventions for older adults who are socially isolated.
Drug-drug interactions in hospitalized older adults with acute coronary syndrome – a real-world study in Brazil
Authors: Lima Tiago Aparecido Maschio de , Godoy Moacir Fernandes de
Published: January 2025

Objective: Our aim was to determine the frequency of drug-drug interactions in clinical practice among hospitalized older adults diagnosed with acute coronary syndrome. Methods: This cross-sectional and descriptive study included 119 older adults with acute coronary syndrome who were admitted to a Brazilian public hospital. Potential drug-drug interactions were identified and classified using computerized databases. Adverse events were characterized according to severity, temporal relationship, causality, interactions as a determining factor, and traceability criteria. Results: Of the total sample, 30.25% of participants had ≥ 1 real drug-drug interaction. A total of 53 real drug-drug interactions were identified. The median number of real drugdrug interactions was 1 (maximum 3) per patient; 5.56% of those who experienced real drugdrug interactions died and 94.44% were discharged from hospital. Of the real drug-drug interactions, 47.17% were moderate and 41.51% were serious. Conclusions: Drug-drug interactions resulted in adverse reactions in hospitalized older adults with acute coronary syndrome in a real-world scenario in Brazil.
Application of a good manufacturing practices checklist in food and nutrition units of a socio-educational foundation in the state of Pará, Brazil
Authors: Mendes Mariana Pinheiro Campos , Silva Evelyn Carolaine Veloso da , Lima Evely Letícia Rodrigues de , Souza Clara Mariana Silva de , Prazeres Alan Reis dos , Souza João Hamilton Pinheiro de , Coutinho Eliane de Castro , Santos Seidel Ferreira dos , Silva Elen Vanessa Costa da , Silva Josyane Brasil da
Published: January 2025

The production and supply of meals must occur in an orderly and categorized manner, as quality in processing can negatively impact consumer health. In this context, evaluating good manufacturing and handling Practices through tools that can identify risks and minimize hazards is essential to ensure safe food. Thus, the aim of this study was to evaluate Good Manufacturing Practices in Food and Nutrition Units (UANS) responsible for meals served to adolescents in a Socio-educational Foundation located in the State of Pará, Brazil. A total of 15 UANS were evaluated, of which 6 operated with centralized meal preparation and 9 with decentralized meal preparation. For this purpose, the checklist recommended by the National Health Surveillance Agency, described in RDC No. 275 of October 21, 2002, was applied. The results showed that 33.33% (2/6) of the centralized UANS, which prepare meals within the Socio-educational Unit itself, were classified as Group 1, meaning they were deemed suitable with minor adjustments. However, 100% (9/9) of the decentralized UANS, where meal preparation occurs outside the Socio-educational Unit and only distribution takes place, were classified as Group 2, requiring more significant adjustments related to building infrastructure, facilities, movable equipment, utensils, handlers of raw materials, ingredients, and packaging. Adjustments for non-compliant items are necessary to ensure the provision of safe food from a sanitary perspective for the adolescents served.
Dejetos cunícolas na produção de mudas de couve ornamental
Authors: Silva Bruno Callai da , Klinger Ana Carolina Kohlrausch , Silva Erick , Schmidt Denise , Rasche Patrícia , Pedrozo Silvana Alves
Published: January 2025

O objetivo deste estudo foi avaliar a porcentagem (PE), a velocidade de emergência (VE) e o rendimento (R) de componentes de Brassica oleracea var. ornamental cultivada em substrato com níveis crescentes de dejetos de coelho (DC). Pra tal, foi conduzido ensaio biológico, em delineamento inteiramente casualisado, com cinco tratamentos e 10 repetições cada, sendo estes: 0DC, 25DC, 50DC,75DC e 100DC, com 0%, 25%, 50%, 75% e 100% de DC respectivamente. Avaliou-se a VE, a PE, e R de componentes. Os dados foram analisadosatravés de ANOVA, seguida do teste T. A PE e a VE em dias foram de: 66%, 56%, 60%, 54% e 2%; 7,52±1,21; 8,07±2,35; 7,20±1,08; 7,87±2,04; 8±0 para os tratamentos 0DC, 25DC, 50DC, 75DC e 100DC respectivamente. Os componentes do R que apresentaram diferença foram parte área, raiz e caule. Todavia, apenas 25DC e 50DC são viáveis, pois, as plântulas 0DC embora tenham sobrevivido não apresentaram vigor e as 75DC e100DC tiveram sobrevivência de 70% e 10% respectivamente.
Tecnologias da informação e comunicação aplicadas ao transporte escolar: inovações e impactos
Authors: Moraes Matheus Henrique Morato de , Lima Lara Batista Ferreira de , Roriz Marcos , Garcia Liosber Medina , Carvalho Willer Luciano
Published: January 2025

Avanças as política e tecnologias de transporte escolar é fundamental para garantir o acesso ao ensino as crianças. Neste sentido, este estudo tem como objetivo investigar como as inovações tecnológicas da informação e comunicação têm sido aplicadas no setor de transporte escolar, como um enfoque na segurança, eficiência e inclusão dos alunos. Para tal, realizou-se uma revisão de literatura sobre tecnologias aplicadas, como sistemas de rastreamento por GPS, aplicativos móveis e softwares de gerenciamento de rotas. Os resultados indicam melhorias significativas na gestão do transporte escolar, com redução de custos operacionais, aumento da segurança e satisfação dos pais, e maior acessibilidade para estudantes de áreas remotas. Essas tecnologias digitalizam as informações, otimizam as rotas dos ônibus, monitoram em tempo real e facilitam a comunicação entre motoristas, escolas e pais. Contudo, a integração desses dados é crucial para evitar retrabalho e permitir o uso de múltiplas ferramentas, beneficiando a criação de políticas públicas, órgãos de controle e a sociedade civil. A padronização de formatos de dados e o respeito às normas de privacidade, como a Lei Geral de Proteção de Dados Pessoais (LGPD), são desafios que precisam ser abordados para consolidar esses benefícios. O estudo conclui que a contínua adoção dessas inovações é essencial para transformar e aprimorar a experiência educacional dos alunos, promovendo um ambiente mais seguro e eficiente.
Atenção primária nas ações de controle da hanseníase: estudo avaliativo sob a ótica dos médicos
Authors: Oliveira Maria Eduarda Alves , Martins Marcílio Belarmino , Ferreira Kassy Jhones Moreira , Souza Marilena Maria de
Published: January 2025

A hanseníase é uma doença infectocontagiosa, causada pelo Mycobacterium leprae, que afeta a pele e os nervos periféricos, apresentando elevada endemicidade no Brasil. A Atenção Primária à Saúde (APS) possui profissionais multidisciplinares constituindo as equipes da Estratégia de Saúde da Família (ESF), atuando em ações de promoção, prevenção, cura e reabilitação. O médico da APS possui papel fundamental na equipe, principalmente no diagnóstico precoce e no manejo terapêutico das doenças. Com isso, a pesquisa buscou avaliar os serviços da APS nas Ações de Controle da Hanseníase (ACH), a partir dos médicos, identificando em que medida os atributos são alcançados por unidade de saúde, comparando os indicadores de orientação da APS nas ACH entre as unidades. Trata-se de uma pesquisa avaliativa, realizada no município de Cajazeiras-PB, hiperendêmico para hanseníase, utilizando o instrumento validado por Lanza (2014). Coletou-se os dados através de um formulário online, mediante assinatura do TCLE, os quais foram organizados em quadros e posteriormente discutidos. Identificou-se que mais de 50% das unidades de saúde mostraram-se bem orientadas considerando todos os atributos analisados e, além disso, foram identificados os atributos com maiores deficiências, assim como os principais empecilhos que corroboram para o mau desempenho em algumas unidades de saúde.
Research on the Generation of Ceramic Decorative Patterns from the Perspective of AIGC
Authors: Wang Xiaoyan , Zhong Zhiling , Wen Lanlan , Liu Tao
Published: January 2025

In traditional ceramic art, the design of decorative patterns is at the core of its aesthetic value. However, traditional design methods are limited due to their low efficiency and singular style. This study aims to promote the development of ceramic decorative pattern design through technological innovation, to meet the personalized and diversified aesthetic demands of modern people for ceramic decorative patterns. Researchers have proposed a method based on fine-tuning the Stable Diffusion large model with the LoRA model, combined with prompt optimization technology, to achieve high-quality generation of ceramic decorative patterns. This method not only significantly improves design efficiency but also breaks through the limitations of traditional styles, creating innovative and personalized decorative patterns. By introducing deep learning and artificial intelligence technologies, this study has brought revolutionary changes to the field of ceramic decorative pattern design, enabling designers to quickly respond to market changes and create works that meet contemporary aesthetics. This has not only propelled the development of ceramic art to a higher level and depth but also provided designers with a fast, flexible, and innovative design tool.
COMPARISON OF HAEMORRHOIDECTOMY OUTCOMES USING LIGASURE SMALL JAW DEVICE VERSUS CONVENTIONAL MILLIGAN-MORGAN TECHNIQUE
Authors: SHAHEEN U , SABIR M , HUSSAIN S , TAHIR JA , AKHTAR N , RASHEED U
Published: January 2025

Haemorrhoids are a common anorectal condition, affecting about 10% of the population. Hemorrhoidectomy remains the preferred treatment for grade III and IV haemorrhoids, with the Milligan-Morgan technique being the traditional method since 1937. Recently, the LigaSure vessel sealing system has emerged as a novel approach, utilizing bipolar electro-thermal technology for precise tissue sealing. Studies suggest LigaSure offers benefits such as reduced operating time, less intraoperative bleeding, lower postoperative pain, and shorter hospital stays. This study aims to compare postoperative pain, operative time and blood loss during the procedure between the LigaSure techniques and the Milligan-Morgan to optimize patient outcomes. Objective: To compare haemorrhoidectomy with Ligasure Small Jaw device versus conventional Milligan Morgan technique in terms of operation time, intra-operative blood loss and postoperative pain. Methods: 100 patients were included in this study. Patients were randomly assigned to 2 groups: Group A (Haemorrhoidectomy with Ligasure small jaw device) and Group B (Milligan Morgan Haemorrhoidectomy); 50 patients in each group. The data from both groups was recorded on a predesigned questionnaire and the required variables for the study i.e. VAS pain score, operative time and blood loss etc. were noted and the data was analyzed via SPSS version23.Results: The majority of patients were aged 50-59 years (45%), with a mean age of 46.01 ± 7.377 years. Males predominated (67%), and most patients had a healthy BMI (55%), with a mean BMI of 25.03 ± 3.1. Grade 4 hemorrhoids were more common (65%) than grade 3 (35%). Most patients experienced symptoms for 12-24 months (52%) and had an ASA score of 1 (79%). In Group A, the mean operative time was significantly shorter at 39.66 ± 6.46 minutes compared to 59.8 ± 14.04 minutes in Group B (p<0.001). Group A also had a shorter mean hospital stay (2.16 ± 0.911 days vs. 2.18 ± 1.043 days, p<0.001). Blood loss was significantly lower in Group A (51.04 ± 6.22 ml) compared to Group B (71.76 ± 9.8 ml, p<0.001). Pain scores on the day of surgery were lower in Group A (5.1 ± 0.57) than Group B (6.5 ± 0.50, p<0.001), a trend that continued on the 1st, 14th, and 28th postoperative days (p<0.001).Conclusion: Through our comprehensive analysis, we affirm that the Ligasure technique demonstrates superior outcomes in terms postoperative pain assessed via Visual Analog Scale (VAS), operative blood loss, duration of hospitalization, and operative time when compared to the Milligan-Morgan technique.
Missed and misdiagnosis of immunodeficiency: Good syndrome presenting as persistent COVID-19 shedding
Authors: Chiang Valerie , So Tiffany C. H. , Li Philip H.
Published: January 2025

A 61-year-old man was referred to the immunology clinic due to prolonged COVID-19 infection and absent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodies. His infection, confirmed by polymerase chain reaction (PCR) testing upon returning to Hong Kong from Vancouver, resulted in a 31-day hospitalization due to persistent positive PCR results, despite his remaining asymptomatic. Laboratory tests revealed lymphopenia, low immunoglobulin levels, and unremarkable serum protein electrophoresis, with all viral serologies, including HIV, being negative. Although he received 3 doses of the Pfizer BioNTech vaccine, he showed no detectable SARS-CoV-2 antibodies. Further evaluation indicated almost-absent CD19 cells and low CD4 and CD8 counts, and coupled with his history of thymoma, this led to a diagnosis of Good syndrome. The patient began subcutaneous immunoglobulin replacement therapy and was started on long-term valganciclovir for moderate cytomegalovirus antigenemia.
The Effectiveness of Flipped Classroom in Improving English Communication Skills: A Focus on Listening and Speaking
Authors: Wei Xin
Published: January 2025

This research investigates whether the flipped classroom approach increases high-school students English language abilities (mainly listening and speaking skills). For an 8-week intervention, 60 students were randomly assigned to an experimental group who were exposed to the flipped classroom and a control group who were exposed to conventional lecture-based instruction. Pre- and post-tests were conducted to assess improvement in listening comprehension and fluency, accuracy and confidence in speaking. The outcomes indicated a significant difference between the experimental and control groups scores. Listening comprehension improved by 15.9% in the experimental group and only 3.4% in the control group. Likewise, the experimental group also made substantial improvements in speaking abilities. The flipped classroom allowed for an open and engaging learning process where students could practice and apply language in pairs. These results were reinforced by survey and interview responses pointing to increased interest, motivation and satisfaction in experimental group participants. The research here proves that the flipped classroom can be an effective teaching tool for improving English listening and speaking abilities, and offers teachers a template for teachers looking to adopt student-centred methods of instruction.
Facilitating structure-based drug design for human albumin by Artificial Intelligence
Authors: Wang Yixuan
Published: January 2025

With the increase of drug research and development activities, the demand for resources for clinical medical experimental research grows year by year, and the traditional biological experimental methods can no longer meet the requirements of saving the existing resources, so this paper proposes a new method combining protein drug structure prediction and AI artificial intelligence to perform structure-based drug design on the computer. Considering that the medical community has not yet obtained the complete three-dimensional structure of human albumin, it is taken as a full-text research object for subsequent analysis and research. Firstly, the standard amino acid sequence of HSA was extracted from the uniprot protein database and imported into alphafold2 for structural prediction with atomic accuracy, and then the prediction results were fed into the plip tool for non-covalent bonding interactions to explore the potential binding sites and drug pockets. The experimental results indicate that human serum albumin has high drug activity and is a suitable choice as a ligand drug, which needs to be further investigated by related scholars. This study provides a novel method to guide the drug development, which is expected to play an important role in future protein applications and drug repositioning.
The future of macrolide antibiotics: Modification and new discoveries
Authors: Shen Junyi
Published: January 2025

Initially isolated in 1950 from a Streptomyces strain, macrolides have evolved to address chronic lung inflammatory diseases and respiratory tract infections. However, with the emergence of bacterial resistance, there is an urgent need for new antibiotics to alleviate the current situation. The structure of macrolides is characterized by a macrocyclic lactone ring with 14, 15, or 16 atoms, often linked to sugars via glycosidic bonds. The mode of action involves inhibiting bacterial protein synthesis by binding to the ribosome, though recent studies suggest selective interference with certain proteins. Resistance mechanisms include diminished drug binding and macrolide efflux, facilitated by efflux pumps of the mef and msr families. The future of macrolides lies in modifying existing drugs, such as erythromycin, and discovering new antibiotics through genome mining and serendipitous findings. Advanced synthetic platforms can offer promising avenues for creating novel macrolide structures. These strategies offer hope for overcoming bacterial resistance. The article concludes with an optimistic outlook on the future of macrolide antibiotics, driven by continuous scientific innovation and exploration of natural and synthetic pathways.
Study on the Construction of Business Models and Sustainable Development of Retirement Communities
Authors: Ma Weijie
Published: January 2025

As the global trend of aging intensifies, the eldercare industry has increasingly captured the focus of societal concern. In my country, the burgeoning elderly population has rendered the issue of eldercare increasingly prominent, while simultaneously presenting the eldercare industry with unparalleled opportunities for growth. This paper aims to conduct a comprehensive analysis of the market status of the eldercare industry and to anticipate its future prospects. The primary focus of this study is to examine and analyze the current business model of Chinas eldercare industry and to explore strategies for its sustainable development. Utilizing literature review and case study methodologies, the findings reveal that Chinas existing eldercare industry model harbors several areas requiring improvement to ensure sustainable progression. It can be concluded that the eldercare industry in China currently grapples with high costs, a shortage of specialized personnel, inconsistent service standards, and uneven resource distribution. To achieve sustainable development, it is imperative to enhance regulation and standardization, drive innovation in business models, elevate service quality, optimize resource allocation, and foster interdisciplinary collaboration.