bluuebunny/crossref_metadata_2025 huggingface dataset:
Surveillance of Post-Vaccination Side Effects of COVID-19 Vaccines among Saudi Population: A Real-World Estimation of Safety Profile
Authors: Alzarea Abdulaziz Ibrahim , Khan Yusra Habib , Alatawi Ahmed D. , Alanazi Abdullah Salah , Alzarea Sami I. , Butt Muhammad Hammad , Almalki Ziyad Saeed , Alahmari Abdullah K. , Mallhi Tauqeer Hussain
Published: June 2022

Vaccines are considered to be the most beneficial means for combating the COVID-19 pandemic. Although vaccines against SARS-CoV-2 have demonstrated excellent safety profiles in clinical trials, real-world surveillance of post-vaccination side effects is an impetus. The study investigates the short-term side effects following the administration of the Pfizer-BioNTech and Oxford-AstraZeneca vaccines in Saudi Arabia. A cross-sectional quantitative study was conducted among the general population with age ≥ 18 years, from five regions (Central, Northern, Eastern, Southern, and Western Regions) of Saudi Arabia for a period of 6 months (July to December 2021). A self-administered study instrument was used to record the side effects among the COVID-19 vaccine recipients. Of the total 398 participants (males: 59%), 56.3% received Pfizer and 43.7% were vaccinated with AstraZeneca. Only 22.6% of respondents received the second dose of the COVID-19 vaccines. The most commonly reported side effects were pain at the injection site (85.2%), fatigue (61.8%), bone or joint pain (54.0%), and fever (42.5%). The average side effects score was 3.4 ± 2.2. Females, young people, and Oxford-AstraZeneca recipients had a higher proportion of side effects. The Oxford-AstraZeneca vaccine recipients complained more about fever (p < 0.001), bone and joint pain (p < 0.001), fatigue (p < 0.001), loss of appetite (p = 0.001), headache (p = 0.008), and drowsiness (p = 0.003). The Pfizer-BioNTech vaccinees had more pain and swelling at the injection site (p = 0.001), and sexual disturbance (p = 0.019). The study participants also reported some rare symptoms (<10%) including heaviness, sleep disturbance, fainting, blurred vision, palpitations, osteomalacia, and inability to concentrate. This study revealed that both Pfizer-BioNTech and Oxford-AstraZeneca administration was associated with mild to moderate, transient, short-lived side effects. These symptoms corroborate the results of phase 3 clinical trials of these vaccines. The results could be used to inform people about the likelihood of side effects based on their demographics and the type of vaccine administered. The study reported some rare symptoms that require further validation through more pharmacovigilance or qualitative studies.
Adenoviral-Vectored Centralized Consensus Hemagglutinin Vaccine Provides Broad Protection against H2 Influenza a Virus
Authors: Petro-Turnquist Erika M. , Bullard Brianna L. , Pekarek Matthew J. , Weaver Eric A.
Published: June 2022

Several influenza pandemics have occurred in the past century, one of which emerged in 1957 from a zoonotic transmission of H2N2 from an avian reservoir into humans. This pandemic caused 2–4 million deaths and circulated until 1968. Since the disappearance of H2N2 from human populations, there has been waning immunity against H2, and this subtype is not currently incorporated into seasonal vaccines. However, H2 influenza remains a pandemic threat due to consistent circulation in avian reservoirs. Here, we describe a method of pandemic preparedness by creating an adenoviral-vectored centralized consensus vaccine design against human H2 influenza. We also assessed the utility of serotype-switching to enhance the protective immune responses seen with homologous prime-boosting strategies. Immunization with an H2 centralized consensus showed a wide breadth of antibody responses after vaccination, protection against challenge with a divergent human H2 strain, and significantly reduced viral load in the lungs after challenge. Further, serotype switching between two species C adenoviruses enhanced protective antibody titers after heterologous boosting. These data support the notion that an adenoviral-vectored H2 centralized consensus vaccine has the ability to provide broadly cross-reactive immune responses to protect against divergent strains of H2 influenza and prepare for a possible pandemic.
COVID-19 Concerns, Vaccine Acceptance and Trusted Sources of Information among Patients Cared for in a Safety-Net Health System
Authors: Davis Terry C. , Beyl Robbie , Bhuiyan Mohammad A. N. , Davis Adrienne B. , Vanchiere John A. , Wolf Michael S. , Arnold Connie L.
Published: June 2022

We examined COVID-19 concerns, vaccine acceptance, and trusted sources of information among patients in a safety-net health system in Louisiana. The participants were surveyed via structured telephone interviews over nine months in 2021. Of 204 adult participants, 65% were female, 52% were Black, 44.6% were White, and 46.5% were rural residents. The mean age was 53 years. The participants viewed COVID-19 as a serious public health threat (8.6 on 10-point scale). Black adults were more likely to perceive the virus as a threat than White adults (9.4 vs. 7.6 p < 0.0001), urban residents more than rural (9.0 vs. 8.2 p = 0.02), females more than males (8.9 vs. 8.1 p = 0.03). The majority (66.7%) had gotten the COVID-19 vaccine, with females being more likely than males (74.7 vs. 54.5% p = 0.02). There was no difference by race or rural residence. Overall, participants reported that physicians were the most trusted source of COVID-19 vaccine information (77.6%); followed by the CDC/FDA (50.5%), State Department of Health (41.4%), pharmacists (37.1%), nurses (36.7%); only 3.8% trusted social media. All sources were more trusted among black adults than White adults except family and social media. These findings could help inform efforts to design trustworthy public health messaging and clinical communication about the virus and vaccines.
Non-Arteritic Anterior Ischemic Optic Neuropathy Following COVID-19 Vaccination
Authors: Lin Wen-Yun , Wang Jin-Jhe , Lai Chien-Hsiung
Published: June 2022

People are advised to receive a vaccine booster as the Delta and Omicron variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerge, but various adverse ocular reactions after vaccination have been reported. NAION following COVID-19 vaccination appears extremely rarely. Here, we report a case of a 61-year-old female with sudden painless blurred vision developing NAION after receiving ChAdOx1 nCoV-19 (AstraZeneca) vaccination and provide an in-depth explanation of the possible mechanisms regarding the hypercoagulable state after vaccination. Our report adds to the literature on potential adverse ocular effects after COVID-19 vaccination, and we as ophthalmologists recommend that clinicians should increase awareness of this possible ocular complication when evaluating patients with sudden visual disturbance with a recent history of vaccination.
Anti-Vaccine Attitudes among Adults in the U.S. during the COVID-19 Pandemic after Vaccine Rollout
Authors: Choi Jasmin , Lieff Sarah A. , Meltzer Gabriella Y. , Grivel Margaux M. , Chang Virginia W. , Yang Lawrence H. , Des Jarlais Don C.
Published: June 2022

Even though vaccination is the most effective measure against COVID-19 infections, vaccine rollout efforts have been hampered by growing anti-vaccine attitudes. Based on current knowledge, we identified three domains (beliefs, discrimination, and news) as our correlates of primary interest to examine the association with anti-vaccine attitudes. This is one of the first studies to examine key correlates of anti-vaccine attitudes during the critical early stages of vaccine implementation in the United States. An online survey was administered in May 2021 to a non-representative, nationally based sample of adults (N = 789). Using multivariable logistic regression analysis, we found that individuals who expressed worry about COVID-19 (OR = 0.34, 95% CI 0.21, 0.55) and had greater knowledge of COVID-19 (OR = 0.50, 95% CI 0.25, 0.99) were less likely to hold anti-vaccine attitudes. Conversely, individuals who held stigmatizing views of COVID-19 (OR = 2.47, 95% CI 1.53, 3.99), had experienced racial discrimination (OR = 2.14, 95% CI 1.25, 3.67) and discrimination related to COVID-19 (OR = 2.84, 95% CI 1.54, 5.24), and who had been watching Fox News (OR = 3.95, 95% CI 2.61, 5.97) were more likely to hold anti-vaccine attitudes. These findings suggest COVID-19 beliefs, experiences of discrimination, and news sources should be considered when designing targeted approaches to address the anti-vaccine movement.
Efficacy of a Modified Live Porcine Reproductive and Respiratory Syndrome Virus 1 (PRRSV-1) Vaccine against Experimental Infection with PRRSV AUT15-33 in Weaned Piglets
Authors: Duerlinger Sophie , Knecht Christian , Sawyer Spencer , Balka Gyula , Zaruba Marianne , Ruemenapf Till , Kraft Christian , Rathkjen Poul Henning , Ladinig Andrea
Published: June 2022

In this study, the efficacy of the commercial modified live PRRSV-1 vaccine “Ingelvac PRRSFLEX® EU” was assessed in weaned piglets experimentally infected with PRRSV strain AUT15-33. Seventy-four weaned piglets were allocated to five groups. Vaccinated (groups 1, 2, and 5) and non-vaccinated piglets (groups 3 and 4), infected with either a low dose (103 TCID50/dose; groups 2 and 4) or a high dose (105 TCID50/dose; groups 1 and 3) of the virus, were compared regarding clinical signs, average daily weight gain (ADG), lung lesions, viral load in serum, oral swabs, and tissue samples. In comparison to vaccinated animals, coughing increased notably in the second week after challenge in non-vaccinated piglets. During the same time period, vaccinated, high-dose-infected piglets showed significantly higher ADG (p < 0.05) than non-vaccinated, high-dose-infected animals. All infected piglets reached approximately the same viremia levels, but vaccinated animals showed both a significantly reduced viral load in oral fluid (p < 0.05) and tissue samples and significantly reduced lung lesions (p < 0.05). In conclusion, vaccination was able to increase ADG, reduce the amount of viral shedding via oral fluids, and reduce the severity of lung lesions and the viral load in tissue samples under experimental conditions.
A Novel Model to Predict Electric Vehicle Rapid Charging Deployment on the UK Motorway Network
Authors: Chamberlain Keith , Majeed Salah Al
Published: June 2022

Recent transformations from internal combustion engines (ICE) to electric vehicles (EVs) are challenged by limited the driving range per charge, thereby requiring the improvement or substantial deployment of rapid charging infrastructure to stimulate sufficient confidence in EV drivers. This study aims to establish the necessary level of EV motorway service station infrastructure for the United Kingdom (UK) based market. The investigation is founded on increasing the appropriate rapid charger availability and shorter charging times. EV charging patterns are determined, focusing on two Volkswagen iD3 EV models by measuring power curves across field-based rapid chargers at one-minute intervals. Datasets are analysed throughout rapid charging field tests. Additionally, variance synthesis is applied to establish variables within this study’s assessment for rapid charger capacity requirements in the UK. The operational performance for the utilised rapid chargers is correspondingly recorded, whilst the EV range is calculated at 3 miles per kWh, revealing a mean power delivery rate of just 27 kW per hour using a 50 kW rapid charger. Time-of-day charging sessions are used to generate data that is then amalgamated into our previous study data, confirming that rapid charging points on UK motorways are used primarily for EV journey range extension. If fully utilised for an entire 24h period, 434 chargers (with a variance consolidation number of 81) are required to service the UK-based motorway EV user base. Moreover, this study establishes that simply replacing current fuel pumps with individual rapid chargers on a like-for-like basis reduces availability and support for novel and existing users and may impact short-term grid availability.
Evaluation of Tumor Grade and Proliferation Indices before and after Short-Course Anti-Inflammatory Prednisone Therapy in Canine Cutaneous Mast Cell Tumors: A Pilot Study
Authors: Klahn Shawna , Dervisis Nikolaos , Lahmers Kevin , Benitez Marian
Published: June 2022

Glucocorticoid administration is a common clinical practice that attempts to decrease the inflammation associated with and improve the resectability of canine mast cell tumors (MCTs). However, the impact of neoadjuvant glucocorticoids on the histological features and proliferation indices of canine MCTs is unknown. The objective of this study was to evaluate changes in tumor grade, mitotic count, Ki67, AgNOR, and AgNORxKi67 scores following short-course anti-inflammatory neoadjuvant prednisone in canine patients with MCTs. This was a prospective single-arm pilot study. Client-owned dogs with treatment-naïve cytologically confirmed MCTs were enrolled. Patients underwent an initial incisional biopsy followed by a 10–14-day course of anti-inflammatory prednisone and surgical resection. All histological samples were randomized, masked, and evaluated by a single pathologist. Unstained paired pre- and post-treatment samples were submitted to a commercial laboratory for Ki67 and AgNOR immunohistochemical analysis. There were 11 dogs enrolled with 11 tumors. There were no statistical differences between the pre- and post-treatment histological parameters of mitotic index, Ki67, AgNOR, or Ki67xAgNOR. There were no clinically significant alterations between pre-treatment and post-treatment in the assignment of tumor grades. A short course of anti-inflammatory prednisone does not appear to alter the histological parameters that affect grade determination or significantly alter the proliferation indices in canine MCTs.
Small Ruminant Farming in Tribal Areas of Dera Ghazi Khan, Punjab, Pakistan
Authors: Jamal Muhammad Ameen , Khan Samiullah , Su Yanhua , Yang Chang , Zhao Heng , Xu Kaixiang , Jiao Deling , Cheng Wenmin , Rauf Abdul , Ali Mahboob , Ahmad Sohail , Qing Yubo , Wei Hong-Jiang
Published: June 2022

Provincially Administered Tribal Areas (PATA) of Punjab-Pakistan are comprised of hilly mountains with small ruminants as a sole source of income. In this study, farming practices, productivity, health and the economic value of sheep were evaluated in PATA through a survey of farmers (n = 138) holding 11,558 heads of sheep. Out of a total population, 87% were non-descriptive flocks, and 9% and 4% were purebred flocks belonging to the Kajli and Thali populations, respectively. Sheep flocks were mainly (86%) reared under the traditional production system and had a delayed onset of puberty. There was low influence of season on the reproduction, and the majority of flocks (78%) were bred throughout the year. The lack of proper vaccination and poor management exposed the flocks to bacterial, viral and parasitic infections, which lead to high mortality in lambs (~22%) and adults (~32%). The share of sheep in farmers livelihood was 42%, and only 20% of producers’ living standard was improved with sheep farming, but the rise in rearing more sheep was quite low (20%). Although the livestock department arranged farmers’ training, the majority of farmers (83%) never participated in training and had no knowledge of modern technologies. Collectively, the traditional sheep production systems, poor management, lack of vaccination, marketing channels and farmers training hampered the sheep rearing and producers’ livelihood in the PATA of Punjab-Pakistan. However, developing model livestock farms, conducting farmer training, establishing a viable market for dairy products, and introducing subsidy policy interventions can improve the sheep farming in these areas.
Inguinal Hernia in Nonhuman Primates: From Asymptomatic to Life-Threatening Events
Authors: de la Garza Melissa A. , Hegge Sara R. , Bakker Jaco
Published: June 2022

In this study, a review of available data and literature on the epidemiology and anamnesis of inguinal hernias in nonhuman primates, as well as on their clinical evaluation and surgical management, was conducted. Inguinal hernias are assumed to be relatively common in male nonhuman primates. Clinical signs are usually limited to a visible or palpable mass in the groin region without pain or systemic illness. Most hernias contain omentum. Careful monitoring is an acceptable treatment option for those animals. Size, the danger of incarceration, and the presence of strangulation are important factors when considering surgical repair. A strangulated inguinal hernia is an emergency, requiring prompt surgery to avoid tissue necrosis and death. Imaging techniques, as well as computed tomography (CT), ultrasonography, and magnetic resonance imaging (MRI), provide information about the anatomical characteristics of the suspected region, allowing for a diagnosis and treatment. An inguinal hernia repair can be performed with either open surgery or laparoscopic surgery. The hernia repair can be achieved by mesh or suture. Decisions regarding which repair technique to use depend on the surgeon′s skill level and preference. Complication and recurrence rates are generally low. The most common postsurgical complication is a recurrence of the hernia. Contraceptive measures are not indicated in breeders, as there is no known hereditary component, and the presence of hernia does not appear to affect fertility, nor does it predispose to occurrence, recurrence, or incarceration.
Phenotypic and Genotypic Screening of Colistin Resistance Associated with Emerging Pathogenic Escherichia coli Isolated from Poultry
Authors: Badr Heba , Samir Abdelhafez , El-Tokhi Essam Ismail , Shahein Momtaz A. , Rady Flourage M. , Hakim Ashraf S. , Fouad Ehab Ali , El-Sady Engy Farahat , Ali Samah F.
Published: June 2022

Chickens continue to be an important reservoir of zoonotic multidrug-resistant illnesses. Antimicrobial resistance correlated with colistin has emerged as a critical concern worldwide in the veterinary field and the public health sector. The current study investigated the prevalence of multidrug-resistant avian pathogenic Escherichia coli among chicken farms in three Egyptian governorates, focusing on colistin resistance assessment. A total of 56 Escherichia coli isolates were recovered out of 120 pooled samples obtained from diseased chicken broilers (46.7%). The E. coli isolates were serotyped to nine different serotypes; the highest incidence was for O125 (n = 18). The E. coli isolates demonstrated multidrug-resistant patterns against 10 antibiotics, especially clindamycin, tetracycline, streptomycin and ampicillin, by 100, 100, 96.4 and 92.9%, respectively. On the other hand, colistin resistance was 41.1% using AST. All E. coli isolates displayed positive colistin resistance growth on chromogenic medium, but only 25% represented this positivity via MIC estimation and Sensititre kit. PCR results revealed that all isolates harbored mcr-1, but no isolates harbored the other 2–5 mcr genes. In conclusion, the study demonstrated the emergence of multidrug-resistant, especially colistin-resistant, E. coli among chicken broiler flocks, and mcr-1 is the master gene of the colistin resistance feature.
Antimicrobial Resistance of Clinical and Commensal Escherichia coli Canine Isolates: Profile Characterization and Comparison of Antimicrobial Susceptibility Results According to Different Guidelines
Authors: Fernandes Vera , Cunha Eva , Nunes Telmo , Silva Elisabete , Tavares Luís , Mateus Luísa , Oliveira Manuela
Published: June 2022

Background: Pyometra is a diestrual chronic disease frequently associated with Escherichia coli. Initial pyometra treatment involves empiric antimicrobial therapy whose suitability should be confirmed by antimicrobial susceptibility testing. Antimicrobial resistance is a major health issue for veterinary medicine, rendering surveillance studies essential. Our goal was to determine the susceptibility profile of E. coli isolates obtained from healthy and pyometra-presenting dogs and to compare the application of different antimicrobial susceptibility guidelines. Methods: The antimicrobial susceptibility profile (ASP) of 74 E. coli isolates was determined by disk diffusion, using six antimicrobials commonly used in veterinary medicine. Profiles were assessed by CLSI VET01S, CLSI M100 and EUCAST guidelines. β-lactamases-encoding genes blaTEM, blaSHV and blaOXA were detected by multiplex PCR. Biofilm production ability was evaluated by pellicle formation assays in Luria–Bertani medium. Results: Variations in the resistance frequency were observed for amoxicillin/clavulanic acid, cephalexin and cefotaxime (29.7–54.1%, 10.8–16.2% and 1.4–4.1%, respectively). Results varied slightly between clinical and commensal isolates, as well as their biofilm-forming ability. Genes blaTEM, blaSHV and blaOXA were detected in 25.5%, 11.8% and 9.8% of isolates, respectively. Conclusions: Results show the importance of ASP determination in veterinary isolates and the need for using standardized and validated testing methods and harmonized interpretive criteria.
Describing and Characterizing the Literature Regarding Umbilical Health in Intensively Raised Cattle: A Scoping Review
Authors: Van Camp Matthew B. , Renaud David L. , Duffield Todd F. , Gomez Diego E. , McFarlane William J. , Marshall Joanne , Winder Charlotte B.
Published: June 2022

The objective of this scoping review was to describe and characterize the existing literature regarding umbilical health and identify gaps in knowledge. Six databases were searched for studies examining umbilical health in an intensively raised cattle population. There were 4249 articles initially identified; from these, 723 full text articles were then screened, with 150 articles included in the review. Studies were conducted in the USA (n = 41), Brazil (n = 24), Canada (n = 13), UK (n = 10), and 37 additional countries. Seventeen were classified as descriptive, 24 were clinical trials, and 109 were analytical observational studies. Umbilical outcomes evaluated in descriptive studies were infection (n = 11), parasitic infection (n = 5), and hernias (n = 2). Of the clinical trials, only one examined treatment of navel infections; the remainder evaluated preventative management factors for navel health outcomes (including infections (n = 17), myiasis (n = 3), measurements (n = 5), hernias (n = 1), and edema (n = 1)). Analytical observational studies examined risk factors for umbilical health (n = 60) and umbilical health as a risk factor (n = 60). Studies examining risk factors for umbilical health included navel health outcomes of infections (n = 28; 11 of which were not further defined), hernias (n = 8), scoring the navel sheath/flap size (n = 16), myiasis (n = 2), and measurements (n = 6). Studies examining umbilical health as a risk factor defined these risk factors as infection (n = 39; of which 13 were not further defined), hernias (n = 8; of which 4 were not further defined), navel dipping (n = 12), navel/sheath scores as part of conformation classification for breeding (n = 2), measurements (n = 3), and umbilical cord drying times (n = 2). This review highlights the areas in need of future umbilical health research such as clinical trials evaluating the efficacy of different treatments for umbilical infection. It also emphasizes the importance for future studies to clearly define umbilical health outcomes of interest, and consider standardization of these measures, including time at risk.
Towards Green Driving: A Review of Efficient Driving Techniques
Authors: Younes Maram Bani
Published: June 2022

The exponential increase in the number of daily traveling vehicles has exacerbated global warming and environmental pollution issues. These problems directly threaten the continuity and quality of life on the planet. Several techniques and technologies have been used and developed to reduce fuel consumption and gas emissions of traveling vehicles over the road network. Here, we investigate some solutions that assist drivers to follow efficient driving tips during their trips. Advanced technologies of communications or vehicle manufacturing have enhanced traffic efficiency over road networks. In addition, several advisory systems have been proposed to recommend to drivers the most efficient speed, route, or other decisions to follow towards their targeted destinations. These recommendations are selected according to the real-time traffic distribution and the context of the road network. In this paper, different high fuel consumption scenarios are investigated over the road networks. Next, the details of efficient driving techniques that were proposed to tackle each case accordingly are reviewed and categorized for downtown and highway driving. Finally, a set of remarks and existing gaps are reported to researchers in this field.
A IMPORTÂNCIA DO CÓDIGO DE BARRAS NA CADEIA DE SUPRIMENTO PARA UMA EMPRESA DO RAMO DE FUNDIÇÃO
Authors: Santos Osmildo Sobral dos , Mendes Everton Almeida , Conceição Marcio Magera , Silva Arthur Vieira Dutra , Oliveira Elias Silva de
Published: June 2022

No intuito de obter um estoque com o melhor desempenho das atividades operacionais em relevância a este artigo, tem-se como objetivo principal a demonstração e a inserção do código de barras na empresa objeto de estudo e seus benefícios para a organização e identificação dos produtos. A eficiência na cadeia de suprimentos é importante em todos os estágios da produção desde o recebimento até a chegada ao cliente, onde se vale de estratégias e planejamento das operações com tomadas de decisões, da otimização dos processos com a abordagem das ferramentas de controle, que, em conjunto a utilização do código de barras, auxiliam na movimentação e armazenagem propiciando um maior controle do fluxo e rastreamento de materiais. Para a realização desse artigo fez-se o uso de livros, artigos e o estudo de caso da empresa. O método de pesquisa adotado foi a exploratória, com a técnica de observação dos fatos para a obtenção de informações para a pesquisa e análise de dados e assim de propor soluções para o problema encontrado. Conclui-se que o código de barras pode ser um fator indispensável para qualquer empresa que busca padronizar os seus processos e obter uma melhor qualidade de serviço no mercado.
FATORES PSICOLÓGICOS QUE INTERFEREM NO COMPORTAMENTO DE COMPRA DO CONSUMIDOR, ATRAVÉS DO ESTUDO DA TEORIA MOTIVACIONAL DE MASLOW
Authors: Clariano da Silva Djalma Donizetti
Published: June 2022

Sabe-se que as teorias das necessidades são cruciais por trás de grande parte do entendimento do comportamento humano e, em particular, no local de trabalho e pelo consumidor. Os autores fornecem uma visão geral das teorias de necessidades semeadas através da teoria motivacional, também com o objetivo de descobrir as diferenças (às vezes conhecidas como necessidades deficitárias) e serem necessidades (às vezes conhecidas como necessidades de crescimento) e, em seguida, vinculá-las a estratégias empresariais, um melhor entendimento do consumidor e melhor exploração do mercado.
DA EDUCAÇÃO INTEGRAL PROPOSTA POR ANÍSIO TEIXEIRA À EDUCAÇÃO EM TEMPO INTEGRAL NO BRASIL: PERCURSO SÓCIO-HISTÓRICO
Authors: De Araújo Elaine Maestre Polido , Stentzler Márcia Marlene
Published: June 2022

Neste artigo analisamos o processo de implantação de escolas de tempo integral no Brasil em contexto histórico, tendo por base Anísio Teixeira. Ele almejava melhorias na qualidade da educação, principalmente para estudantes de famílias mais pobres. Defendeu a educação integral, um dos pilares para escolas de tempo integral. A primeira experiência em meados do século XX teve lugar no estado da Bahia. Por meio de pesquisa bibliográfica e revisão de literatura, abordamos iniciativas de educação em tempo integral no país, a qual tem se espalhado aos poucos pelas escolas. Dialogamos também com a legislação educacional, visando compreender como ela tem orientado as práticas nas escolas de educação básica. Entre os principais autores estão Cavaliere (2003; 2009; 2010) e Teixeira (1959; 1976). O estudo indica que a educação em tempo integral no Brasil ainda se encontra em estruturação, pois depende de políticas educacionais e investimentos.
ARTE, DESIGN E TECNOLOGIA EM ABORDAGEM TRANSDISCIPLINAR: DESENVOLVIMENTO DE ANIMATRÔNICOS COMO OBJETOS DE APRENDIZAGEM PARA ESTUDO DE ROBÓTICA
Authors: Godin Juliana Martins , Cruz Enderson Neves , Rezende Edson José Carpintero , Silva Sérgio Antônio
Published: June 2022

A utilização de elementos mediadores para construção de conhecimentos em cursos técnicos profissionalizantes tem sido tema recorrente em pesquisas, congressos e seminários. Materiais concretos e ferramentas lúdicas podem estimular funções cognitivas a fim de promover educação com foco em um processo de ensino e aprendizagem mais dinâmico e significativo. Este artigo apresenta resultados de um trabalho transdisciplinar entre as áreas de Arte, Design, Eletrônica e Informática, cujo objetivo foi desenvolver técnicas para construção de animatrônicos a fim de aplicá-los ao ensino e aprendizagem de robótica. A metodologia foi estruturada no método pesquisa-ação colaborativa, a partir das seguintes etapas: (i) Planejamento: incluindo seleção dos estudantes, levantamento bibliográfico, análise de documentos, agendamentos de reuniões, aplicação de questionários preliminares e observações, coleta de dados por meio de questionários; (ii) Ação: desenvolvimento da estrutura eletrônica e mecânica do protótipo, registros e observações das ações implementadas; desenvolvimento da estrutura eletrônica e mecânica do protótipo; (iii) Encontro dos dados. Os resultados apontaram para o fato de que as abordagens transdisciplinares utilizadas superaram a perspectiva tradicional, de modo a permitir um processo de aprendizagem mais dinâmico e significativo. Este trabalho sugere uma educação baseada no fazer criativo, que pressupõe a construção de projetos baseados na integração entre Arte, Design e Tecnologia, abrindo portas para conexões curriculares nas quais alunos e professores trabalham ativamente em busca de soluções.
Vasoactive use in early goal-directed therapy in dogs with severe sepsis and septic shock
Authors: SÜLEYMANOĞLU Havva , TURGUT Kürşat , ERTAN Merve , İNCE Mehmet Ege , NASERİ Amir
Published: June 2022

The goal of this study was to see how to evaluate the changes in macrovascularand microvascular parameters in survivors (Sv) and non-survivors (non-Sv) dogs with severe sepsis and septic shock (SEVS & SEPS) in response to goal-directed hemodynamic optimization at the intensive care unit (ICU), and to evaluate norepinephrine (NE) and dobutamine (DT) ICU applications, and their effectiveness for predicting death. Thirty-five dogs with SEVS & SEPS were used. NE was given to 10 hypotensive dogs, despite receiving a single bolus of fluid therapy, at a constant infusion rate of 1.5 µg/kg/min for 2 h. The rate of NE infusion was doubled (3.0 µg/kg/min) if the clinical response was insufficient after 2 hours. DT was administered to 5 dogs with left ventricular systolic dysfunction (LVSD) (LVS’<7.5 cm/s) at a constant infusion rate of 5 µg/kg/min for 2 h. The Sv and non-Sv groups had no major differences in macrovascular and microvascular characteristics, PW-TDI septal mitral annulus systolic (S') and early diastolic (E') velocities, or DT applications. The only difference was the use of NE applications. non-Sv received a greater amount of NE, while Sv received a smaller amount of NE. In contrast, more Sv received a greater amount of DT applications. Total mortality rate was 25.7%. In conclusion, the effects of DT and NE in dogs with SEVS & SEPS are limited. To provide evidence-based guidelines for dogs with SEVS & SEPS, more research is needed.
GAMBARAN KEBIASAAN MENYIKAT GIGI PADA SISWA SDN 4 SANDINGTAMAN KECAMATAN PANJALU KABUPATEN CIAMIS JAWA BARAT
Authors: Dede Elis Siti Wahyuni Nur Fauziah  , Herijulianti Eliza , Nurnaningsih Hera , Fatikhah Nurul
Published: June 2022

Menyikat gigi merupakan salah satu usaha untuk mencegah terjadinya kerusakan pada gigi. Potensi menyikat gigi secara baik dan benar merupakan faktor yang cukup penting untuk pemeliharaan kesehatan gigi dan mulut. Berhasilnya pemeliharaan kesehatan gigi dan mulut juga dipengaruhi oleh faktor penggunaan alat, metode penyikatan gigi, serta frekuensi dan waktu menyikat gigi yang tepat. Hasil Riset Kesehatan Dasar (Riskesdas) tahun 2018 menyatakan bahwa proporsi perilaku penduduk menyikat gigi setiap hari di Jawa Barat mencapai 96,79%, perilaku yang benar dalam menyikat gigi hanya mencapai 2,89%. Sedangkan proporsi perilaku penduduk menyikat gigi setiap hari di kabupaten Ciamis mencapai 96,98%, perilaku yang benar dalam menyikat gigi hanya mencapai 2,09%. Tujuan penelitian ini ialah untuk mengetahui gambaran kebiasaan menyikat gigi pada siswa SDN 4 Sandingtaman kecamatan Panjalu kabupaten Ciamis Jawa Barat. Penelitian ini merupakan penelitian deskriptif, penelitian dengan cara observasi yaitu wawancara melalui aplikasi whatsapp untuk mengetahui kebiasaan menyikat gigi pada siswa kelas I sampai V. Hasil penelitian menunjukkan teknik menyikat gigi siswa yang digunakan yaitu teknik horizontal dengan persentase 42,2%. Frekuensi menyikat gigi 2x sehari  pagi setelah sarapan dan malam sebelum tidur dengan persentase 46,7%. Alat menyikat gigi  yang digunakan yaitu sikat gigi sesuai kriteria anak SD dengan persentase 82,2%. Siswa menggunakan pasta gigi yang mengandung fluoride dengan persentase 100%. Simpulan bahwa siswa SDN 4 Sandingtaman memiliki kebiasaan menyikat gigi kurang baik.
ASUPAN ENERGI, ASUPAN PROTEIN, AKTIFITAS FISIK DAN STATUS GIZI PADA REMAJA PUTRI PUTRI DI PONDOK PESANTREN
Authors: Rahayu Putri Sri , Suparman Suparman , Dewi Maryati , Agung Fred , Hastuti Widi
Published: June 2022

An imbalance in nutrient adequacy levels can cause nutritional problems, both undernutrition, and overnutrition. Adolescent energy needs are influenced by activity, basal metabolism, and the increased need to support accelerated growth and development during adolescence, while protein requirements in adolescents are determined by the amount of protein to support lean body mass and the amount of protein needed to increase lean body mass during accelerated growth. . This research was conducted with a cross-sectional design, a minimum sample of 44 people, taken by simple random sampling. The data collected included data on energy intake, protein intake, using 24-hour recall, physical activity using a 24-hour record of physical activity, and nutritional status obtained using anthropometric measurements and weighing. The study found that 81.8% had less energy intake, 90.9% had less protein intake and 45.5% of female students had light physical activity, 54.5% had moderate activity and 13.6% of female students had poor nutritional status, 65, 9% had normal nutritional status, 15.9% overweight and 4.5% obese. The proportion of samples with less energy intake had a poor nutritional status of 16.7% or higher than good intake. The proportion of samples with low protein intake had a 15% or higher nutritional status than those with good protein intake.
EVIDENCE-BASED CASE REPORT (EBCR) PIJAT BAYI UNTUK BAYI USIA 3-6 BULAN
Authors: Rifani Alvia Aghni , Sofiyanti Santi
Published: June 2022

Periode pranatal sampai dengan masa balita disebut sebagai masa keemasan karena terjadinya pertumbuhan dan perkembangan sel-sel otak. Rangsangan atau stimulasi dapat mempengaruhi pertumbuhan dan perkembangan bayi melalui berbagai jalur. Salah satu cara stimulasi dini adalah melalui sentuhan lembut seperti pijat bayi (baby massage) dan baby gym.  Sebuah studi menunjukan sepertiga dari anak-anak di negara berkembang tidak mencapai pertumbuhan dan perkembangan optimal. Berdasarkan data kemenkes 2016, 27,7% balita mengalami stunting. Kondisi ini dapat mempengaruhi perkembangan kognitif serta sosioemosional anak. Penelitian yang dilakukan di wilayah Jakarta menunjukan prevalensi terjadinya keterlambatan perkembangan pada anak usia 3-60 bulan sekitar 10%. Stimulasi yang diterima bayi secara langsung mempengaruhi pekembangan otak serta peningkatan berat badan bayi. Stimulasi secara dini dapat dilakukan melalui sentuhan seperti pijat bayi. Diego dkk pada tahun 2005 menunjukan bahwa pijat bayi yang dilakukan pada bayi premature terdapat peningkatan rata-rata 31-49% berat badan dan diikuti peningkatan lingkar kepala serta tinggi badan. EBCR ini bertujuan untuk mengetahui pengaruh pijat bayi pada usia bayi 3-6 bulan. Metode yang digunakan adalah Evidence Based Case Report. Sumber pencarian menggunakan 3 database yaitu: Google Sholar, Portal Garuda dan Pubmed dengan tahun terbit 2019. Kriteria inklusi yang digunakan yaitu artikel yang full text, Bahasa inggris/Bahasa Indonesia, terdapat empat jurnal yang dapat digunakan sesuai dengan tujuan dari Evidance Based Case Report. Hasil dari EBCR ini menunjukan stimulasi berupa pijat bayi dan baby gym dapat meningkatkan kualitas serta kuantitas tidur bayi serta membangun ikatan kasih sayang antara ibu dan bayi.  
Kata kunci: Pijat Bayi, Bayi usia 3-6 bulan, dan kualitas tidur
Potential of Dragon’s Blood as a Space Radiation Protectant Especially on Brain-Liver Bystander Effect
Authors: Li Bo , Li Tianmei , Han Chu , Liu Yuanyuan , Zhong Xia , Cao Yanlu , Deng Yulin
Published: June 2022

During space manned missions, radiation is a serious health risk. Radiation can not only directly cause damage to target organs but also trigger side effects to affect nontarget organs. Dragon’s Blood (DB) is a traditional Chinese Dai medicine that has been proven to exhibit radioprotective effects in our lab previously. It can alleviate brain damage, hematopoietic dysfunction, and gastrointestinal damage caused by radiation in rats, but its mechanism of action is not clear yet. In order to study the effect of brain irradiation on the damage to the liver and the protective effects of Dragon’s Blood, herein, liquid chromatography coupled with a mass spectrometer was used to analyze the total differential protein expression in the rat liver after 30 Gy Co
60
γ
-ray whole-brain irradiation with/without administration of Dragon’s Blood for 10 days before irradiation. A total of 4557 proteins were identified in the rat liver. A total of 299 coexpressed differential proteins were screened in the RAD/CON group indicating that brain radiation significantly affected the liver’s metabolic system (such as drug and arachidonic acid metabolism), chemical carcinogenesis, and peroxisome process. A total of 85 differential proteins were screened in the DB/RAD group. Results indicated that Dragon’s Blood significantly regulated the expression of 26 proteins to normal levels (Msrb2, Txnrd2, Samm50, Pir, Pex11a, etc.) mainly through regulating the metabolism and redox homeostasis process. The results of molecular docking and network pharmacology found that the main effective radiation protection components in Dragon’s Blood are natural chalcones, flavan, and phenolic derivatives.
Effect of Aluminum on Nitroform - A DFT Study
Authors: Türker Lemi
Published: June 2022

Trinitromethane (nitroform, NF) is an interesting substance. It acts as an oxidizer and forms salts/salt-like materials. In the present study, nitroform and aluminum interaction has been investigated within the limitations of density functional theory at the level of unrestricted B3LYP/6-311++G(d,p). The composites having formula of NF+Al and NF+2Al are considered. Since aluminum has an unpaired electron in the ground state, various multiplicities arise for the composites of present interest. Some geometrical, physico chemical, quantum chemical and spectral data have been obtained and discussed. The results indicate that the interaction between aluminum and nitroform is moderate in the case of NF+Al(d) which (has doublet multiplicity) and only some bond angle and length distortions happen. In the case of NF+2Al(s) composite, drastic effect of aluminum atom results in C-NO2 bond rupture of nitroform. On the other hand, the triplet state of NF+2Al, (NF+2Al(t)) perturbations caused by the aluminum is also moderate. In each case the aluminum atom acquires partial positive charge.
PENGARUH STRUKTUR MODAL, UKURAN PERUSAHAAN DAN PROFITABILITAS TERHADAP HARGA SAHAM SYARIAH YANG TERDAFTAR DI JAKARTA ISLAMIC INDEX PERIODE 2015-2019
Authors: Muthmainah Qolbiyati , Asakdiyah Salamatun , Hidayat Taufik
Published: June 2022

This study aims to examine and analyze the effect of capital structure, firm size and profitability partially and simultaneously on Islamic stock prices. The object of research is a company listed on the Jakarta Islamic Index (JII) for the 2015-2019 period. The research method uses quantitative methods with causal research design (causality). The research sample was 12 companies for 4 years of research so that the number of observations in this study was 48 observations. The analysis technique in this study uses the IBM SPSS For Windows program with multiple linear regression models. The results showed that capital structure had an insignificant negative effect on Islamic stock prices, firm size had a positive and significant effect on Islamic stock prices, and profitability had a positive and significant effect on Islamic stock prices, and together with capital structure, firm size, and profitability. significant effect on Islamic stock prices.
Determination Of Pigment Content And Antioxidant Activities Of Some Chlorophyta Species Isolated From Altınapa Dam Lake (Konya/ Turkey)
Authors: AŞIKKUTLU Baran , AKKÖZ Cengiz
Published: June 2022

Due to global warming, the decrease in water resources and the difficulties in reaching clean water are important problems for people today. New studies on water resources and the living creatures living in these water resources provide information about the status of these resources. Algae are necessary organisms for the survival of other living things in the environment because they provide oxygen to the environment they live in and form the first step of the food chain. Algae are very important living things because they are the primary producers in the aquatic ecosystems they are in. Due to these importance, many studies are carried out on microalgae. In this study, it was aimed to determine the chlorophyll-a, chlorophyll-b, total carotenoid content and antioxidant activities of some green algae species isolated from the benthic algae flora of Altınapa Dam Lake, which is one of the important drinking water sources of the city of Konya. Three Chlorophyta (Chlorella vulgaris, Acutodesmus obliquus, Monoraphidium minutum) species showing high growth potential under culture conditions were selected and studies were carried out with these species. Since Monoraphidium minutum species belonging to Chlorophyta, gives IC50 values close to the reference antioxidant, it has been concluded that it can provide an economic contribution in the food and pharmaceutical industries when produced under appropriate conditions.
Memorias trans y violencia estatal. La Ley Integral para Personas Trans y los debates sobre el pasado reciente en Uruguay
Authors: Sempol Diego
Published: June 2022

En el marco de la aprobación de la Ley Integral para Personas Trans se produjo la emergencia en Uruguay de una serie de testimonios trans que denunciaron violencias estatales históricamente invisibilizadas. En este artículo se analizan los factores que ayudan a comprender su emergencia y las disputas sobre el pasado reciente que esos sentidos instalan
ÍNDICE
Authors: Páginas Revista
Published: June 2022

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Las relaciones de amistad en la ciudad griega, entre arcaísmo y helenismo
Authors: Plácido Domingo
Published: June 2022

La amistad, philía, constituye en la Grecia arcaica un elemento básico en las relaciones sociales de la aristocracia, como instrumento para consolidar la cohesión social. En la etapa formativa de los jóvenes, las relaciones de philía, entre ellos mismos y con relación de los pedagogos, están impregnadas de éros, lo que da pie a la formación de relaciones de hetairía, como instrumento de reproducción a través del sympósion, donde los jóvenes, todavía como paîdes, entran en los grupos de adultos, para el ejercicio de la vida militar y de la política, como hoplitas y ciudadanos de pleno derecho. Como adultos, en la relaciones de amistad predomina la colaboración militar y la solidaridad política. Las luchas políticas aparecen en gran medida como la proyección de las relaciones de amistad y hostilidad, “hacer bien a los amigos y mal a los enemigos”. Tales son los mecanismos de la philía en la pólis entre el arcaísmo y el clasicismo democrático, hasta que la situación crítica de los orígenes del Helenismo la reducen al ámbito privado de las escuelas, como el Jardín de Epicuro.
PRESENTACIÓN
Authors: Baravalle María del Rosario
Published: June 2022

Presentación del Dossier Temático
Testigos directos de la naturaleza paraguaya. Novedad y tradición en las historias y crónicas jesuitas entre el Renacimiento y la Ilustración
Authors: Justo María de la Soledad
Published: June 2022

Los cronistas jesuitas presentaron al público lector europeo una importante colección de textos en los cuales, entre otros temas, se describía a la naturaleza americana.  Los padres jesuitas utilizaron como herramientas epistemológicas en las narraciones sobre América y su naturaleza, por un lado, la experiencia personal de viajeros que fueron testigos oculares de lo que narraron y por otro, el conocimiento de las lenguas nativas. Esta combinación fue lo que los habilitó como testigos fieles. También debe tenerse en cuenta que un criterio de validación importante fue su pertenencia a la Orden y sus servicios a las coronas católicas. La Ilustración generó nuevas herramientas conceptuales para el soporte epistemológico y cuestionó severamente los dispositivos humanistas utilizados por los autores jesuitas.
PRESENTACIÓN
Authors: Bortolotti Mariana
Published: June 2022

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La monumentaria urbana en el escenario de las luchas políticas locales
Authors: Vaca Rosana
Published: June 2022

Este artículo reconstruye la historia local de la ciudad de San Nicolás de los Arroyos, provincia de Buenos Aires, a través del análisis de la destrucción de un monumento emblemático. El proyecto político instalado en el interior bonaerense a través del golpe de Estado de 1955, adoptó una forma particular a nivel urbano. Se intenta demostrar que en torno a la destrucción de un monumento puede girar una serie de intereses que difícilmente se entienden si no se tienen en cuenta las identidades locales, y, en especial, cómo estas últimas se articulan en un momento determinado con el contexto político nacional.
Ciencia, tecnología y difusión: las reflexiones de Ernesto Mezey sobre el Quebracho Colorado del Gran Chaco y su extracto tánico
Authors: Caballero Gabriela Dalla-Corte
Published: June 2022

En el año 1946 el químico Ernesto Mezey publicó en Buenos Aires su obra titulada “El Quebracho Colorado y su extracto tánico”, con la intención de reconstruir las investigaciones llevadas adelante por un gran número de científicos y empresarios vinculados a la fabricación de tanino. El análisis historiográfico que hizo Mezey permite reconstruir sus reflexiones en torno al futuro de la exportación del quebracho después de la Segunda Guerra Mundial, y en especial la competencia internacional de dos de las empresas más reconocidas: “La Forestal” británica establecida en la República Argentina, así como la española “S. A. Carlos Casado Limitada, Compañía de Tierras” fundada en el Paraguay. El artículo analiza la orientación otorgada por Mezey al extracto tánico durante las conferencias que ofreció en Madrid y en Barcelona en el año 1953 ante los miembros de la Asociación Química Española de la Industria del Cuero, así como el sentido de la revista “Tecnología del Cuero” fundada por él en Buenos Aires en 1960 en calidad de presidente de la Asociación Argentina de los Químicos y Técnicos de la Industria del Cuero (AAQTIC).