bluuebunny/crossref_metadata_2025 huggingface dataset:
Discovery of a Novel Antibacterial Protein CB6-C to Target Methicillin-Resistant Staphylococcus Aureus
Authors: Zhang Haipeng , Liu Yuehua , Xu Qijun , Inam Muhammad , He Chengguang , Jiang Xiuyun , Jia Yu , Ma Hongxia , Kong Lingcong
Published: August 2021

Given the serious threat of multidrug-resistant bacterial pathogens to global healthcare, there is an urgent need to find effective antibacterial compounds to treat drug-resistant bacterial infections. In our previous studies, Bacillus velezensis CB6 with broad-spectrum antibacterial activity was obtained from the soil of Changbaishan, China. In this study, with MRSA as an indicator bacterium, an antibacterial protein was purified by ammonium sulfate precipitation, a Sephadex G-75 column, a QAE-Sephadex A 25 column and RP-HPLC, which demonstrated a molecular weight of 31405.48 Da by SDS-PAGE. LC-MS/MS analysis indicated that the compound was an antibacterial protein CB6-C, which had 88.5% homology with chitosanase Csn produced by Bacillus subtilis 168. An antibacterial protein CB6-C showed an effective antimicrobial activity against gram-positive bacteria (in particular, the MIC for MRSA was 16 μg/mL), low toxicity, thermostability, stability in different organic reagents and pH values, and an additive effect with conventionally used antibiotics. Mechanistic studies showed that an antibacterial protein CB6-C exerted anti-MRSA activity through destruction of lipoteichoic acid (LTA) on the cell wall. In addition, an antibacterial protein CB6-C was efficient in preventing MRSA infections in In Vivo models. In conclusion, this protein CB6-C is a newly discovered antibacterial protein and has the potential to become an effective antibacterial agent due to its high therapeutic index, safety, nontoxicity and great stability.
MYCL promotes iPSC-like colony formation via MYC Box 0 and 2 domains
Authors: Akifuji Chiaki , Iwasaki Mio , Kawahara Yuka , Sakurai Chiho , Cheng Yusheng , Imai Takahiko , Nakagawa Masato
Published: August 2021

Induced pluripotent stem cells (iPSCs) have the potential to differentiate into any cell in the body and thus have attractive regenerative medicine potential. Current iPSC generation protocols, however, have low efficiency and show variable quality among clones. This variability influences the efficiency and reproducibility of iPSC differentiation. Our previous study reported that MYC proteins (c-MYC and MYCL) are important for the reprogramming efficiency and germline transmission of iPSCs, but that MYCL can generate iPSC colonies more efficiently than c-MYC. However, why c-MYC and MYCL cause different reprogramming efficiencies is unknown. In this study, we found that MYC Box 0 (MB0) and MB2, two functional domains conserved in the MYC protein family, contribute to the phenotypic difference and promote iPSC generation in MYCL-induced reprogramming. Proteome analysis suggested that in MYCL-induced reprogramming, cell adhesion-related cytoskeletal proteins are regulated by the MB0 domain, while RNA processes are regulated by the MB2 domain. These findings provide a molecular explanation for why MYCL has higher reprogramming efficiency than c-MYC.
Shaping the Brazilian landscape: a process drive by land occupation, large-scale deforestation, and rapid agricultural expansion
Authors: Parente Leandro , Mattos Ana Paula , Baumann Luis , Lopes Vanessa , Silva Elaine Barbosa , Nogueira Sérgio , Mesquita Vinícius Vieira , Ferreira Laerte Guimarães
Published: August 2021

Brazil is one of the largest food producers in the world, a leading role that prompted a profound process of anthropization of itslandscapes. Knowing the dynamics and dimension of these transformations is essential for a more efficient and sustainable useof the country’s natural resources. Thus, in this study we present, based on an unprecedented sample design and interpretationof 85,152 sample points in Landsat images, the area estimates of the main land cover and land use classes in Brazil, as wellas their annual transitions, from 1985 to 2018. Our results indicate that, of the 850 Mha that comprise the national territory,294.2 Mha±1.44%were anthropized in 2018, with ~34%of this area converted after 1985. In this period, there was a loss of98.2 Mha±2.27%of natural vegetation, and an increase of 55.1 Mha±0.64%in the pasture areas and 28.2 Mha±0.29%in theareas of annual crops. The transition analysis showed that 83.07 Mha±1.31%of pastures and 9.64 Mha±0.45%of agriculture(annual, semi-perennial, and perennial combined) occurred over natural vegetation, 18.12 Mha±0.63%of pastures wereconverted to agriculture, while another 9.7 Mha±0.45%were abandoned, which can serve as important land reserves for otheruses. The vast public dataset, approaches (simple, robust, and straightforward), codes and tools (open and available) utilizedin this study can be easily employed in any other region of the world, in support of environmental monitoring and improvedterritorial governance practices.
A Pragmatic Evaluation of a Public Health Knowledge Broker Mentoring Education Program: A Convergent Mixed Methods Study
Authors: Clark Emily , Dhaliwal Bandna , Ciliska Donna , Neil-Sztramko Sarah , Steinberg Marla , Dobbins Maureen
Published: August 2021

Background: Public health professionals are expected to use the best available research and contextual evidence to inform decision making. The National Collaborating Centre for Methods and Tools developed, implemented, and evaluated a Knowledge Broker mentoring program aimed at facilitating organization-wide evidence-informed decision making in ten public health units in Ontario, Canada. The purpose of this study was to pragmatically assess the impact of the program. Methods: A convergent mixed methods design was used to interpret quantitative results in the context of the qualitative findings. Quantitatively, participants’ knowledge and skills for finding, interpreting, and using evidence were measured before and after program completion via multiple-choice tests. Changes in scores were assessed using paired t-tests. Qualitatively, program participants and management at enrolled public health units were interviewed to explore the effect of program participation. A secondary analysis of these interviews was conducted to determine whether organizations met their evidence use goals set at baseline, and to identify key factors related to implementation of EIDM within the organization. Results: Post-program scores for knowledge and skills for EIDM were higher compared to pre-program scores (mean difference = 14.0%, 95% CI 8.2%, 19.8%). Organizations met their goals for evidence use to varying degrees. Key themes identified that support an organizational shift to EIDM include definitive plans for participants to share knowledge during and after program completion, embedding evidence into decision making processes, and supportive leadership with organizational investment of time and resources. The location, setting or size of health units was not associated with attainment of EIDM goals; small, rural health units were not at a disadvantage compared to larger, urban health units. Conclusions: The Knowledge Broker mentoring program effectively increased participants’ knowledge and skill, allowing them to share their learning and support change at their health units. When paired with organizational supports such as supportive leadership and resource investment, this program holds promise as an innovative knowledge translation strategy for organization wide EIDM among public health organizations.
Lateral Knee Pain Favors the Diagnosis of Anterior Cruciate Ligament Injury and its Postoperative Assessment Potentially Contributes in Treatment Follow- Up; A Pilot Study
Authors: Pourmokhtari Masoome , Razeghi Ali , Taghipour Nikta
Published: August 2021

Background: Anterior Cruciate Ligament (ACL) reconstruction is a standard technique for treatment of patients with an ACL tear. According to clinical observations, lateral knee pain is highly associated with a teared ACL, this correlation so far has remained unnoticed in the literature. In this study, we aim to investigate the relationship of lateral knee pain with diagnosis of torn ACL.Methods: This pilot study was conducted on 30 candidates of ACL reconstruction. The participants underwent surgical reconstruction of ACL; Then Visual Analogue Scale (VAS) was used to measure pain at three time points of preoperative, first and second postoperative visits. Results: A total of 26 participants (86.7%) were male with a mean age of 27.3±5.06 years. The results demonstrated that the intensity of lateral knee pain felt by the subjects significantly diminished during subsequent postoperative referrals (P-value<0.001). However, other variables including sex, age, and type of surgery (bone-patella tendon-bone and hamstring tendon) caused no significant difference in terms of pain reduction (p>0.05). Conclusions: Lateral knee pain is likely related with anterior cruciate ligament tear and favors its diagnosis. Also, the evaluation of lateral knee pain may contribute in Anterior Cruciate Ligament reconstruction (ACLR) monitoring in the follow-up stage.
Personal positioning of oncology patients in palliative care: a mixed-method study
Authors: Silva Hellen Luiza Meireles , Valério Pedro Henrique Martins , Barreira Cristiano Roque Antunes , Peria Fernanda Maris
Published: August 2021

Background
The condition of advanced oncological disorders demands a complete health care, although attention has been predominant on physical aspects. To consider personal positioning entails other aspects when dealing with patients’ diseases – such as their existential aspects – expanding forms of care. This study aims to comprehend the personal positioning of oncology patients receiving palliative care.
Methods
This is a cross-sectional, convergent parallel mixed-methods study. Seventy-one oncology patients in palliative care cooperated with this study, 14 of whom participated in a qualitative approach and 56 in a quantitative approach only. In the former approach, we conducted a phenomenological interview and, in the latter, we used tools to measure meaning of life (PIL-Test), quality of life (EORTC QLQ C-30), anxiety and depression (HADS), and to collect sociodemographic data. Data obtained through the interview were analyzed according to the principles of Classical Phenomenology, and the quantitative data were analyzed through generalized structural equation models.
Results
Our results showed that patients regained their focus on life, accentuating its possibilities and distancing themselves from the impact of their condition, such as imminent death, which was associated with giving up fighting depression. These signs were observed in 21% of the participants. This demands a tenacious fight that supports a positioning nurtured by sensitivity. Related to such position is the religious belief in life continuation, together with their awareness of the meaning of their own lives. Additionally, we found a direct association between purpose in life and an increase in the scores of functional scales (p < 0.01) and a decrease in scores of symptoms (p < 0.01), anxiety (p = 0.02) and depression (p < 0.01). The last elements to appear and structure the patients’ experience were their intense will to live and the value of life.
Conclusions
Through the complementarity of a mixed-method approach, this study acknowledged the existential positioning of oncology patients in palliative care that may help in more comprehensive and real treatment plans, contributing for humanization in this area.
Changes in sleep patterns of college students in Israel during COVID-19 lockdown, a sleep diaries study.
Authors: Lan Anat , Kotler Danielle , Kronfeld-Schor Noga , Stukalin Yelena , Einat Haim
Published: August 2021

Objective
To prevent and reduce the spread of COVID-19, governments around the world apply social restrictions and lockdowns. Such lockdowns significantly alter daily routine and habits. A growing body of research indicates that lockdowns affect sleep and circadian rhythms. The current study further explores that effect using sleep logs for a relatively long duration including lockdown and post-lockdown periods in Israel.
Methods
For five consecutive weeks, both during lockdown and during post-lockdown periods, from March 13th 2020 to May 12th 2020, Israeli students were asked to fill out daily sleep logs in which they report their sleep and wake times. The participants were also asked to fill out the Morningness-Eveningness Questionnaire (MEQ) in the beginning of the study.
Results
Data show increase in sleep duration and a later midsleep point during lockdown, compared to post-lockdown periods, both on workdays and on weekends. An interaction between chronotype and lockdown are also observed; Morning types sleep more both during lockdown and during post-lockdown periods. Interestingly, the midsleep point of late chronotypes is later during both workdays and weekends even during lockdown when social constrains on sleep time are in part removed.
Discussion
Overall, the current results based on detailed and relatively long-term sleep logs analysis confirm previous work using more limited measures such as one-time questionnaires. A lockdown period affects sleep-wake behavior: during lockdown people sleep duration is increased and their sleep onset is delayed. Nevertheless, the circadian preference of individuals is conserved across conditions.
Causal discovery of drivers of surface ozone variability in Antarctica using a deep learning algorithm
Authors: Kumar Pankaj , Kuttippurath Jayanarayanan , Mitra Adway
Published: August 2021

The discovery of causal structures behind a phenomenon under investigation has been at the heart of scientific inquiry since the beginning. Randomized control trials, the gold standard for causal analysis, may not always be feasible, such as in the domain of climate sciences. In the absence of interventional data, we are forced to depend only on observational data. This study demonstrates the application of one such causal discovery algorithm using a neural network for identifying the drivers of surface ozone variability in Antarctica. The analyses reveal the overarching influence of the stratosphere on the surface ozone variability in Antarctica, buttressed by the southern annular mode and tropospheric wave forcing in mid-latitudes. We find no significant and robust evidence for the influence of tropical teleconnection on the ground-level ozone in Antarctica. As the field of atmospheric science is now replete with a massive stock of observational data, both satellite and ground-based, this tool for automated causal structure discovery might prove to be invaluable for scientific investigation and flawless decision making.
Genetic Detection and Phylogenetic Relationship of Babesia Species Infecting Domestic Dogs from Select Regions in Kenya
Authors: Ngoka Ismail Thoya , Mbogo Kevin , Kyallo Martina , Obiero David , Pelle Roger
Published: August 2021

The Babesia genus has more than 100 species which are transmitted by ticks and infects humans, livestock and wildlife, some of which are zoonotic. New species continue being discovered which are poorly characterized. Locally, Babesia species occur in wildlife and livestock. Published literature on the species infecting dogs is limited.Local management practices enable close interaction between wildlife, livestock and humans. The societal role of dogs enable them serve as conduits for pathogens.Canine babesiosis causes a severe disease in dogs which can be fatal. Treatment required is lengthy and expensive. Current control methods rely on acaricide use. A vaccine against the disease is needed. Genetic characterization of local canine Babesia species would lay foundations for such development and assess any zoonotic potential.Molecular and bioinformatic methods i.e. DNA extraction (143 dogs sampled), PCR, sequencing and bioinformatic analysis were used in the study.13 samples were positive for Babesia canis; prevalence 9.0%, 95% confidence interval, (0.0437 to 0.1381).From the 13 positive samples, 2 were identified as Babesia canis vogeli; prevalence 1.4%, 95% confidence interval, (0.0138 to 0.142).While 11 were identified as Babesia canis rossi; prevalence 7.69%, 95% confidence interval, (0.033 to 0.12).Babesia rossi and Babesia vogeli were 84.6% and 15.4% of cases respectively. Phylogenetic analysis revealed the Kenyan B.rossi sequences to be closely related to B.rossi sequences from black-backed jackals. The B.vogeli sequences were closely related to a B.vogeli sequence obtained from a pet cat in China.Babesia rossi is known to cause the most severe form of canine babesiosis, 84.6% of the cases were positive for this parasite which requires immediate and aggressive medical intervention. The role of wildlife in the maintenance of the parasites especially B.rossi was noted, control measures would of necessity have to incorporate this component of the parasite lifecycle.
HIV-Associated Multiple Drug Resistant Tuberculosis in a Pregnant Woman: Clinical Course, Treatment Efficacy and Perinatal Outcomes
Authors: Kukurikа A. V. , Yurovskаya E. I. , Serdyuk O. V.
Published: August 2021

A clinical case of HIV-associated multiple drug resistant tuberculosis in a pregnant woman is presented. The clinical situation was complicated since during the main course of treatment this patient had two pregnancies and delivery with an interval of less than 2 years, and the onset of the disease occurred during the early period in the first pregnancy. This case demonstrates effective treatment of the specific disease and favorable perinatal outcomes. The article assesses medical tactics, analyzes the time of diagnosis, complex therapy, the choice of the way of delivery, considers the need for interdisciplinary interaction at all stages of observation to improve the quality of care.
Morphine Epidural Analgesia in Spine Deformity Surgery
Authors: Ukolov Konstantin Yu. , Aizenberg V. L. , Arzhakova N. I.
Published: August 2021

Objective. Introduced comparative analysis of two methods of anesthesia during surgery dorsal correction of the spine deformity. Material and Methods. The quality of analgesia was assessed in 123 patients using hemodynamic parameters, biochemistry markers of stress, blood loss value and frequency of early postoperative complications. Total 42 patient underwent surgery under general anesthesia with mechanical ventilation, using sevoflurane and fentanyl. In 81 patients used general anesthesia, combined with epidural analgesia using 15 morphine (100 mcg/kg in 10–12 ml of saline). Results. Use of morphine epidural analgesia in addition to general anesthesia increase quality of nociception defence, significantly decrease consumption of narcotic analgesics, anesthetics and relaxants, decrease blood loss by 10 % and frequency of complications by 20 %.
The Thromboelastography: Clinical Significance of Functional Fibrinogen Test
Authors: Bulanov Andrey Yu. , Yatsckov K. V. , Bulanova E. L. , Dobrova N. V.
Published: August 2021

Introduction. The hemostatic system is a frequent subject of interest of critical care. Critical hemostasis has been studied most commonly using thromboelastography. Objectives. Presented study report the experience in the use of special TEG technology fictional fibrinogen test. Material and Methods. As the main working area of FF-test should be marked posthemorrhagic coagulopathy, a situation demanding close attention to the function of the platelets when combined with hyperfibrinogenemia (increase in fibrinogen associated with nonspecific inflammation, gestational hyperofibrinogenemia). Results. A significant difference (more than 2 g/l) between the level of fibrinogen of the plasma is estimated by the method of Claus and FF-test can serve as a marker of dysfibrinogenemia. Conclusion. The clinical importance of the methodology is a predictor of thrombotic and haemorrhagic problems, the diagnostic marker, a reference point for the purpose of transfusion therapy.
Praktik Arsitek dalam Pencarian Keseimbangan Baru
Authors: Winata Suwardana
Published: August 2021

Title: Architect Practice in Search of Balance in New Norm

 

Epidemic Covid 19 enforce us to retrospect our everdayness living, including how architects do for living and for the architectural practice. These condition makes some re- adjustement in architectural  program, in some level must renovate totally. The biggest problem in architect profession is the project coordination, because social distancing and large number of meeting member must reduced to minimal level. This condition pushs architects to review their working process in studio and on the projects field. Physical studio is no longer a good place to collaborate and must transform into the digital studio. Digital system become a bridge to connect between stakeholders and the architects. Digital tools and method becoming an extention tools for our eyes and sense. Digital methods and practices suddenly become a daily activities for every level in architecture firms, such as Big Data. The colabortive works in digital format become important, one of them is Building Information Modelling, works as collabortive tools in virtual digital studio. The coding and the scripting are the next language for architect must learn, beside the architecture itself. Within the epidemic, disruption of profession is not a discourse anymore, but a fact that must commenced. Creativity and colaborative is the survival tools in today harsh life .
HEMICHOREA-HEMIBALLISMUS INDUCED BY NON-KETOTIC HYPERGLYCEMIA: CASE REPORT
Authors:   Service De Neurologie, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc., Ajamat Mohammed , Assoufi Naoufal ,   Service De Medecine Interne, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc., Benmoh Youssouf ,   Service De Neurologie, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc., Satte Amal ,   Service De Neurophysiologie, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc., Mounach Jamal ,   Service De Neurophysiologie, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc., Ahmed Bourazza ,   Service De Neurologie, HÃ´pital Militaire dinstruction Mohamed V, Rabat, Maroc.
Published: August 2021

Non-ketotic hyperglycemia with hemichorea-Hemiballismus (HGSC) is a rare complication of a non-equilibrated diabetic disease characterized by a continuous rapid, non-rhythmic, involuntary unilateral movement of the extremities, caused in most cases by decreased activity of the contralateral subthalamic nucleus of the basal ganglia. It may reveal undiagnosed diabetes. We describe here the case of an 84-year-old Moroccan woman followed for type 2 diabetes mellitus under treatment, who presented with abnormal movements of the right half-body. Laboratory tests showed higher blood glucose levels, urinary ketones were negative, brain CT without injection showed high density in the basal ganglia on the left side.
CASE REPORT : RARE CASE OF SMALL BOWEL OBSTRUCTION DUE TO MECKELS DIVERTICULUM
Authors:   MBBS, MS (General Surgery), FMAS, DMAS., Kaur Dhadiala Simranjit , A. Whatkar Abhijit ,   MBBS, DNB (General Surgery), FMAS, DMAS, FCPS, FIAGES.
Published: August 2021

Meckels diverticulum is a rare congenital anomaly of gastrointestinal tract, seen in 2% of population. It was first described by Guilhemus Fabricus Hildonus in 1598. Meckels diverticulum is an anomaly derived from incomplete obliteration of omphalo-mesenteric duct. It is rarely seen in adults, with prevalence of male to female of 2:1. Complications associated with Meckels diverticulum are hemorrhage, inflammation and intestinal obstruction. We present to you a case of 17 year old male with unusual mechanism of small bowel obstruction due to Meckels diverticulum.
MANAGEMENT OF HYPER-MOBILE TISSUE WITH A MODIFIED COMBINE TECHNIQUE OF ZAFRULLA AND HOBKRIK
Authors:   Reader Peoples dental Academy & Research center Bhopal Madhya Pradesh India., Somkuwar Kirti
Published: August 2021

When in partially edentulous patient hyperplastic tissue replaces the alveolar bone, a flabby ridge develops which is often seen in long-term denture wearers. Flabby ridge provide poor retention for the denture fabrication if not recoded properly. A careful consideration and application of Zafrulla and Hobkrik technique of complete denture construction helps practitioner to over cone such conditions easily. This article describes procedure performed for flabby ridge patient and demonstrates Zafrulla and Hobkrik combination impression technique.
THE WORK CULTURE IN ISLAMIC SCHOOL BASED ON PESANTRENIN LAMPUNG PROVINCE, INDONESIA
Authors:   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., a Sutrisno , Abdul Muin Juhri ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Basyar Syaripudin ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Cahaya Kesuma Guntur ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia.
Published: August 2021

This study was aimed to find 1) the concept of work culture in Islamic school based on pesantren, 3) the principle leadership behavior of Islamic school based onpesantren in building thework culture , and3) the effect of principle leadership behavior of Islamic school based onpesantren in building thework culture. The results of this research shows thatfirst, the concept of work culture in islamic school based on pesantren is Transculturation pesantren-value model , second, the principle leadership behavior in building the work culture applied the task orientation, relationship orientation, and spiritual values orientation. Third, the principal leadership behavior in building a work culture in Islamic school based on pesantren has effect and contribute to the affectivecommitment, normative commitment, job satisfaction and lack of turnover intentions, and also the involvement of workingphysically, emotionally, and cognitively.
VENOUS GANGRENE - AN INSTITUTIONAL EXPERIENCE
Authors: Shanmugavelayutham C. , Abraham Pradip , Kumar Ashok , K. Jayachander
Published: August 2021

Venous gangrene represents the most severe manifestation following deep venous thrombosis (DVT), and presents as acral ischaemic necrosis. The pathophysiology is driven by an acquired coagulopathic state leading to microvascular thrombosis outcomes are generally poor. This study was aimed at analysing the outcomes in these rare group of patients who presented with venous gangrene at a single institution during a two year period.
THE SOCIAL CLASS MYTH OF COLLECTIVISM: A QUALITATIVE STUDY OF THE IMPACT OF SOCIAL CLASS ON FAMILIES MEAL INTERACTION BEHAVIOUR
Authors:   University of Hertfordshire, United Kingdom., Kakay Sheku
Published: August 2021

The class distinction in the Sierra Leonean society is the primary determinant of families access to a balanced diet as well as the level of social interaction at mealtimes. The income earned by families, their status in society, level of education and the type of job they do, significantly determines the type of food they consume. This implies that, social class can act as the arbiter to families access not only to adequate, but quality food. It also influences the food variety available at mealtimes. The study shows that, many Sierra Leonean families experience the problem of daily food affordability challenges, which limits social interaction at the dinner table at mealtimes. Nevertheless, the findings also show that, irrespective of the social standing of families, table etiquette are important to the different social classes, as it provides the foundation for training and socialising children into becoming responsible adults.
HETEROSIDASE ACTIVITIES EXTRACTED FROM THE SEEDS OF THE PITS OF SIX MANGO (MANGIFERA INDICA L) CULTIVARS
Authors:   Laboratory of Agrovalorization, UFR of Agroforestry, Jean Lorougnon GuedeUniversity, Cote dIvoire., Kouame Claude Ya , Mankambou Jacques Gnanwa ,   Laboratory of Agrovalorization, UFR of Agroforestry, Jean Lorougnon GuedeUniversity, Cote dIvoire., Sika Hortense Blei ,   Laboratory of Agrovalorization, UFR of Agroforestry, Jean Lorougnon GuedeUniversity, Cote dIvoire., Jean Bedel Fagbohoun ,   DepartmentofBiochemistry-Genetics, Peleforo Gon CoulibalyUniversity, Korhogo, Cote dIvoire., Yelakan Kinonton Clarisse Kone ,   MicrobiologyandBiotechnologyLaboratory, EcologyResearch Center, Abidjan, Cote dIvoire., Grah Avit Maxwell Beugre ,   Laboratory of Agrovalorization, UFR of Agroforestry, Jean Lorougnon GuedeUniversity, Cote dIvoire., Lucien Patrice Kouame ,   Laboratory of Biocatalysis and Bioprocesses, UFR of Food Science and Technology, Nangui AbrogouaUniversity, Cote dIvoire.
Published: August 2021

Heterosidases are enzymes capable of releasing bioactive moleculesused in cosmetics,nutrition, medicine and in manyotherfields.For thiswork, the presence of glycosidases withheterosidaseactivitiesweredetectedin the seed of the kernels of six cultivars of mangoes (Mangiferaindica L) cultivatedin the region of DALOA (Cote dIvoire) in orderto select new enzymatic sources to original activities. To do this, the crudeenzymaticextractsweretakenfrom the almonds of kernels of the LOCAL, KENT, CAMEROUN, TARDIVE, GREFFE and SUCETTE cultivars of mangoes. Specificactivitiesweredeterminedfromtheseextractsand thencompared. The heterosidaseactivitiestestedwerethose of the ÃŽÂ²-glucosidase, ÃŽÂ²-galactosidase, ÃŽÂ²-fucosidaseand phosphatase activities. All theseactivitieshave been present in thesecultivars.However, thehighestspecificactivitieswerethose of the LOCAL cultivarfollowed in general by those of the GREFFE cultivar. It thereforeemergedfromthisstudythattheseseeds have enzymaticequipment capable of degradingheterosides. Thesedifferent glycosidases couldconstitute important enzymatictools for the valorization of food and non-foodbiomolecules of agricultural rawmaterials and for the development of industry.
HEMOPTYSIS REVEALING INTRACARDIAC THROMBOSIS: A CASE REPORT OF BEHCETS DISEASE
Authors:   Department of Pneumo-Phtisiology, Moulay Ismail Military Hospital, Meknes, Morocco., Bougrini Youssef , Belghol Reda ,   Department of Pneumo-Phtisiology, Moulay Ismail Military Hospital, Meknes, Morocco., Amine Had Mohamed ,   Department of Pneumo-Phtisiology, Moulay Ismail Military Hospital, Meknes, Morocco., Naji-Amrani Hicham ,   Department of Pneumo-Phtisiology, Moulay Ismail Military Hospital, Meknes, Morocco., Ouarssani Aziz ,   Department of Pneumo-Phtisiology, Moulay Ismail Military Hospital, Meknes, Morocco.
Published: August 2021

Behcets disease is a chronic multisystem disorder characterized by relapsing inflammation for which the underlying histopathology is an occlusive vasculitis. Intracardiac thrombosis is a rare complication of Behcets disease. The management of this involvement is difficult due to the risk of recurrence. We prresent the case of a young man admitted to our hospital for hemoptysis. We discovered a right ventricle thrombus on CT angiogram and we confirmed the diagnosis on echocardiography.
PREVALENCE AND FACTORS ASSOCIATED WITH ROUTINE MEDICAL CHECKUP AMONG PATIENTS ATTENDING MASAKA REGIONAL REFERRAL HOSPITAL, UGANDA
Authors:   Faculty of Health Sciences, Department of Human Anatomy, Islamic University in Uganda, Kampala Campus, Kampala, Uganda., A.B. Aremu , I.B Afolabi ,   Faculty of Science and Technology, Department of Public Health, Cavendish University, Kampala, Uganda Kampala, Uganda., M. Awunor N.S Salaam ,   Faculty of Health Sciences, Department of Human Anatomy, Islamic University in Uganda, Kampala Campus, Kampala, Uganda., A.A Sulayman ,   Faculty of Health Sciences, Department of Human Anatomy, Islamic University in Uganda, Kampala Campus, Kampala, Uganda., O. Ilori ,   Faculty of Health Sciences, Department of Human Anatomy, Islamic University in Uganda, Kampala Campus, Kampala, Uganda., K.U Nwanna ,   Faculty of Health Sciences, Department of Public Health, Victoria University, Uganda., R. Suubi ,   Faculty of Health Sciences, Department of Public Health, Victoria University, Uganda.
Published: August 2021

Globally, Routine Medical checkup is known to be a preventive medicine that opens doors for assessment of well-being status of all individual and decreases the mortality and morbidity of different ailments in communities. attending health checkups may be one of the key reasons of controlling the predisposition and cause of much of the illness, suffering and early death related to chronic illnesses and condition. Its on this ground that this current study sought to elucidate further on factors determining the adherence of people to medical checkups. A descriptive cross-sectional study was carried out among 385 adult respondents attending Masaka regional referral hospital, in Uganda. A structured questionnaire involving open-ended and close-ended questionnaire was used and data was analyzed using SPSS version 26. Overall, 61.3% of study participants have ever heard of routine health check-ups citing hospitals (25.7%) as the most used source of the information. A prevalence of 43.4% represents the percentage of those who do routine health check-up and of which majority engage in only a general examination (14.5%). Overall, more than half of the respondents (56.6%) have never participated in routine health check-ups with their reported reasons of not feeling sick (25.97%). Factors like level of education, Employment, Occupational, exercise practices and level of awareness was statistically significant to uptake of routine heath checkup among the respondent at P< (0.005). Low health check-up rates may translate into inability to detect and intervene with early health challenges among respondents, and this is whereeffort is needed in ensuring that routine health check-up is encouraged especially during times when patients are healthy. There is need to strengthen government efforts and other concerned NGOs to put across specific sensitization programs about routine health check-ups on different media platforms and also utilize other social public means.
EVALUATION DE LACTIVITE FONGIQUE DES EXTRAITS AQUEUX DOCIMUM GRATISSIMUM ET DE CHROMOLAENA ODORATA SUR COLLETOTRICHUM SP. RESPONSABLE DES POURRITURES DES TUBERCULES DE DIOSCOREA ALATA EN CONSERVATION A DALOA, COTE DIVOIRE
Authors:   Laboratoire dAmelioration de la Production Agricole, Universite Jean Lorougnon Guede (UJLoG), BP 150 Daloa, Cote dIvoire., Ahebe Marie Helene Koffi , Dago Faustin Soko ,   Laboratoire dAmelioration de la Production Agricole, Universite Jean Lorougnon Guede (UJLoG), BP 150 Daloa, Cote dIvoire., N Guettia Marie Yah ,   Laboratoire dAmelioration de la Production Agricole, Universite Jean Lorougnon Guede (UJLoG), BP 150 Daloa, Cote dIvoire., Yao Odilon Koffi ,   Laboratoire dAmelioration de la Production Agricole, Universite Jean Lorougnon Guede (UJLoG), BP 150 Daloa, Cote dIvoire., Dolou Charlotte Tonessia ,   Laboratoire dAmelioration de la Production Agricole, Universite Jean Lorougnon Guede (UJLoG), BP 150 Daloa, Cote dIvoire., Taky Hortense Diallo Atta ,   Laboratoire de Phytopathologie, Universite Nangui Abrogoua (UNA), 02 BP 801 Abidjan 02, Cote dIvoire.
Published: August 2021

Ligname, Dioscorea spp. (L) est une importante denree alimentaire qui occupe une place primordiale dans le systeme agricole en Cote dIvoire. Cette plante est cependant sujette a plusieurs maladies au cours de sa culture et pendant sa conservation parmi lesquelles celles causees par divers champignons. Ainsi, les pertes occasionnees par les pourritures des tubercules en conservation, constituent un risque majeur pour la rentabilite economique et pour la securite alimentaire des consommateurs. Cette etude avait pour objectif dinitier une methohede lutte contre les pourritures des tubercules de Dioscorea alata en conservation.par lutilisation dextraits aqueux dOcimum gratissimum et de Chromolaena odorata. Pour ce faire, trois differentes doses (33 g/l 39 g/l et 50 g/l) dextraits aqueux de chacune de ces deux plantes ont ete appliquees sur des rondelles digname prealablement inoculees avec Colletotrichum sp. Les resultats ont montre que la souche fongique inocule aux rondelles de D. alata a cause dimportants degres de pourritures. Aussi, les extraits de Chomolaena odorata et dOcimum gratissimum possedent des activites antifongiques differentes. Ces activites ont ete plus elevee avec lextrait dOcimum gratissimum a 50 g/l que celui de Chomolaena odorata.
STABILITY OF NON-LINEAR DYNAMICAL SYSTEM
Authors:   College of Basic Education University of Mosul/ Mosul/Iraq., Salim Youns Anas
Published: August 2021

The mainobjective of this research is to study the stability of thenon-lineardynamical system by using the linearization technique of three dimension systems toobtain an approximate linear system and find its stability. We apply this technique to reaches to the stability of the public non linear dynamical systems of dimension. Finally, some proposed examples (example (1) and example (2)) are given to explain this technique and used the corollary.
A COMPARATIVE STUDY ASSESSING THE DIFFERENT PATTERNS OF RADIATION REACTIONS IN HEAD AND NECKCANCER PATIENTS UNDERGOING RADIATION THERAPY AT DIFFERENT TIMES OF THE DAY-IN THE MORNING VERSUS EVENING
Authors:   Tiruvarur Medical Centre, Tiruvarur, Tamil Nadu, India., Raman Ponna Dulasi , Sobita Devi Yumkhaibam ,   Department of RadiationOncology, RIMS, Imphal, Manipur, India., Baidya Kishalay ,   Department of RadiationOncology, RIMS, Imphal, Manipur, India., Jaichand Singh Laishram ,   Department of RadiationOncology, RIMS, Imphal, Manipur, India., Dinita Devi Ningthoujam ,   Department of RadiationOncology, RIMS, Imphal, Manipur, India., K. Marak Silchang ,   Department of RadiationOncology, RIMS, Imphal, Manipur, India.
Published: August 2021

Background: Human oral mucosa, is a prime target for radiation induced toxicity in patients undergoing radiotherapy for head and neck cancer. The oral cavity is highly susceptible to direct and indirect toxic effects of cancer chemotherapy and ionizing radiation. In our study we investigated the role of chronotherapy with respect to radiation induced mucositis occurring in the normal oral mucosa and treatment response in tumor tissue in cancer patients undergoing radiation therapy to head and neck region. Materials and Methods: This non-randomized clinical study was done to compare the two different timing schedules in the management of head and neck cancer by external beam radiation therapy by cobalt-60 (Theratron780C). In morning arm (arm A), Patients received external beam radiotherapy (EBRT) by cobalt-60 with SSD of 80cm with daily fractions, five days a week, between 8AMÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â–10 AM whereas in evening arm (arm B), patients received EBRT by cobalt-60 with daily fractions, five days a week, between 3PMÃƒÂƒÃ‚Â‚ÃƒÂ‚Ã‚Â–5 PM. Both the arms received same radiation regimen. Results: The study concluded that in the morning arm the onset of oral mucositis was observed to be significantly delayed and the duration of mucositis was also significantly shorter as compared to the evening arm. Statistically significant difference in severity of mucositis was found between the two arms. Conclusion: Since there is no active measure to minimize normal tissue toxicity, chronomodulated radiotherapy would be a feasible and cost effective treatment strategy that can be put into clinical practice.
GENETIC DIVERGENCE AMONG MAIZE (ZEA MAYS L.) INBRED LINES USING MORPHOMETRIC MARKERS
Authors:   Department of Genetics and Plant Breeding., Awasthi Akshita , Lata S. ,   Department of Genetics and Plant Breeding., Guleria Satish ,   HAREC, Bajaura, CSKHPKV, Palampur., Bhatia Shivani ,   Department of Genetics and Plant Breeding., Thakur Kalpana ,   Department of Agricultural Biotechnology., Rattan Reena ,   Dr.YSPUHF, COHF Neri-Hamirpur., Thakur Naresh ,   Dr.YSPUHF, COHF Neri-Hamirpur.
Published: August 2021

Genetic divergence study is imperative in breeding programmes in order to select distant parents. Forty maize inbred lines were assessed using morphometric markers to identify the potential inbred lines for yield and its component traits. The inbred lines were raised in ÃŽÂ±-RBD design replicated twice during kharif 2019. The morphological diversity analysis was done as per the standard statistical procedures using Mahalanobis D2-statistic. Analysis of variance revealed significant mean sum of squares due to genotypes for all the traits suggesting ample amount of genetic variability present among them. Moderate PCV, GCV and high heritability coupled with moderate genetic advance was observed for grain yield per plant, plant and cob placement height. Grain yield per plant exhibited significant positive correlation with all the traits except days to 50 per cent pollen shed and silking. Path analysis revealed high direct effects of days to 50 per cent pollen shed, harvest index, grains per row and 100 grain-weight on grain yield per plant therefore these morphometric traits would be the best selection indices to select high yielding genotypes. D2-statistics grouped 40 maize genotypes into three clusters. Cluster III has the highest cluster mean values for all the traits.Seven genotypes viz., 4186-4-05-1-1, LM-14, BAJIM-08-27, BIOM 10, LQPM24ÃƒÂ—1114-5, 9180-2, LDH 5(Vivek-21-1) were superior over the best check on the basis of mean performance and disease resistance and were diverse therefore, could be used in maize improvement program.
ANTIBIOTIC RESISTANCE: A COMMON CHALLENGE IN DENTISTRY
Authors:   Assistant Professor, Fakhruddin Ali Ahmed Medical College and Hospital, Barpeta, Assam., Goswami Arunima
Published: August 2021

The discovery and subsequent clinical introduction of antibiotics is one of the most important game changers in the history of medicine. Antibiotics are widely used in dental practice both for therapeutic and prophylactic reason. Unfortunately, in recent years the use of antibiotics has been accompanied by the rapid emergence of antimicrobial resistance causing a major threat to healthcare system. Solid guideline or recommendation is often lacking regarding prescription of antibiotic in dentistry.Issuing antibiotic prescribing guidelines, antibiotic stewardship program, addressing over the counter sale of antibiotics,education programmes can be considered useful for curbing antibiotic abuse. To highlight the severity of the issue, several international declarations have been published to call upon the government around the globe to take action on antibiotic resistance.
RECOGNISING SUSTAINABILITY THROUGH THE CORPORATE REPORTS A REVIEW OF DEVELOPMENT OF DISCLOSURES IN INDIA
Authors:   Current position: Full- time Research Scholar, College of Management and Commerce, Srinivas University, Mangalore. Qualification: Masters in Commerce, (PhD)., Nayak Priyanka , Kayarkatte Narayan ,   Current Position: Research Professor, Srinivas University Mangalore. Qualification: PhD, MBA (Finance/ HR), MA (Economics), CAIIB, LLB (Labour law and Insurance).
Published: August 2021

Purpose: The stride of Sustainability has led to a new form of reporting called Sustainability Reporting. This form of reporting is being widely accepted and has recently surged amongst Indian corporates and researchers. This paper tries studying the evolution of Sustainability Reporting and its development In Indian context. It also attempts to identify the gaps in the available literature, for further research in this area. Design/Methodology: Using the literature published between 2011 and 2020 review is conducted in various aspects of Sustainability Reporting in India. Findings: As Sustainability Reporting became popular in India only two decades back, there are several gaps in the study in this area, leading to abundant dimensions for future research. The role of Policy makers, Regulators and Academicians in development of best practices in reporting also is highlighted. Practical implication: This study shall give a historical perspective of Sustainability Reporting in India and help researchers focus their study on critical areas that need to be researched. Originality/Value: Sustainability Reporting has drawn a large number of attentions amongst the financial stakeholders. There are several research/review being undertaken in this field. However, a review of the development of studies of Sustainability Reporting in India is one of its kinds. No previous research was found which systematically incorporates evolution and development of Sustainability Reporting in Indian context.
ESKİ UYGUR BORÇ SÖZLEŞMELERİNE AİT SEKİZ FRAGMAN
Authors: KESKİN Berker
Published: August 2021

Belirli şartlar altında daha sonra geri verilmek üzere alınan para ya da herhangi değerli bir şeyin karşılığı olan borç, Eski Uygur toplumunda ihtiyaçların karşılanması için sıklıkla başvurulan alışveriş yöntemlerinden biridir. Mevcut sözleşmeler, Uygurların maddi ihtiyaç dışında arpa, buğday, pamuk gibi çeşitli tarımsal ürünler için de borçlandığını göstermektedir. Borcu alan ve borcu veren tarafların birlikte düzenlediği sözleşmeler geri ödeme şartları, kefalet ve tanıklık bilgisini içermektedir. Bu çalışma, Berlin-Brandenburg Bilimler Akademisi, Turfan Koleksiyonu’nda muhafaza edilen sekiz farklı borç sözleşmesine ait fragmanların yayınını konu edinmektedir. Öncelikle borç sözleşmelerinin genel özellikleri ortaya konmuştur. Fragmanların yazı ve harf çevrimi yapılmış, ardından Türkiye Türkçesine aktarılmıştır. Gerekli görülen yerlere notlar eklenen çalışmanın sonunda metinlere ait bir dizin ile tıpkıbasımlar yer almaktadır.
The Language of Christian Ethics. A Definition of Ethical Notions as Illustrated by the Concept of Tadeusz Ślipko
Authors: Rozmarynowska Karolina
Published: August 2021

The reflection that accompanies Christian ethics is concerned with its meaning and originality as seen against the background of various interpretations of morality. It usually includes questions about the characteristic subject matter of its inquiries, assumptions, methods, or inspirations. From the point of view of the considerations undertaken in this article, such reflection should also include the language employed by Christian ethics. In particular, this paper considers the following issues: (1) whether Christian ethics has its specific language; (2) whether it introduces new notions, or assigns specific meanings to notions already present in ethics; and (3) how ethical notions are defined in Christian ethics. These questions are addressed with reference to the philosophical system of Tadeusz Ślipko, one of the most outstanding Polish representatives of Christian ethics.

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Received: 11/02/2021. Reviewed: 23/03/2021. Accepted: 10/05/2021