bluuebunny/crossref_metadata_2025 huggingface dataset:
The Maltese Single Transferable Vote Experience: A Case Study of Gerrymandering?
Authors: Hasancebi Serhat
Published: October 2022

Re-drawing the electoral boundaries to provide benefit to one particular political party and thereby damaging the principle of representation in democracy has been a core issue in political science in the recent years. For years social scientists have been advocating the idea of measuring or preventing the potential for damage that may arise from the existence of the above-mentioned redistricting process. Following this discussion, we investigate the possible gerrymandering phenomenon that might have arisen, or whether there are any asymmetries or partisan biases due to boundary delimitation of the electoral constituencies in the case of the Maltese general elections. From the evidence of various statistical tests and simulations, our conclusion is that we find no evidence of gerrymandering in the 2013 and 2017 Maltese general elections.
JEL codes: K16
Closed-form algebraic expressions for monoprotic weak acid dissolutions
Authors: Caicedo Anthony J. , Morales Juan C. , Arango Carlos A.
Published: October 2022

Closed-form algebraic expressions for the pH of ideal weak acid and weak acid buffer solutions (and their titration with a strong base) were obtained and analyzed with the aid of computer algebra systems. These expressions are used to evaluate, without the use of numerical approximations, the precision and accuracy of different approximations commonly employed to calculate the pH. The closed-form expression for the pH of a buffer solution is used to obtain an analytical expression for the pH stability when a strong base is added. Finally, it is shown that the pH expressions for all the systems under study can be obtained from an unique closed-form expression in terms of an effective weak acid constant and an effective acid concentration.
Modeling Dynamics of the Spread of Crime with Media Impact
Authors: Goswami Naba Kumar , Athithan S.
Published: October 2022

A non-linear mathematical model is developed and analyzed in order to investigate the interactions between the criminal and non-criminal populations while taking into account the influence of media on the non-criminal class. We obtained the basic reproduction number of the model while taking into account constant recruitment and death type demography. The model’s equilibria have been examined , and their stabilities have been thoroughly addressed. The backward bifurcation is presented for basic reproduction number less than one. Sensitivity analysis is conducted on the proposed model to determine the key parameters of basic reproduction number of the model.These model is further expanded to an optimum control problem to investigate the effects of time-dependent crime control rate on the size of the criminal population using Pontryagin’s maximum principle. To demonstrate our analytical findings, we present numerical simulations.
Rotational stability and refractive outcomes of the DFT/DATx15 toric, extended depth of focus intraocular lens
Authors: Barber Kevin M. , O’Connor Sara , Mackinder Philip , Chih Andreea , Jones Brian
Published: October 2022

Purpose: To quantitatively assess postoperative rotational stability and visual acuity with the DFT/DATx15 extended depth of focus (EDOF) toric intraocular lens (IOL).
Methods: In this prospective case series, thirty-five patients with a calculated IOL power between +15.0 D and +25.0 D, corneal astigmatism between 0.75 D and 2.25 D, and no significant ocular pathology underwent cataract surgery. Primary outcome was rotational stability of the IOL at 1 month post-operatively. Secondary outcomes included residual refractive astigmatism, absolute residual astigmatism prediction error, and monocular distance and intermediate visual acuities.
Results: Mean absolute postoperative IOL rotation was 1.1 ± 0.2 degrees, with no rotation of more than 3 degrees at the final visit. Monocular mean best spectacle-corrected distance visual acuity (BSCDVA) improved from logMAR 0.27 ± 0.030 to 0.078 ± 0.017 (P < .001). Monocular uncorrected distance visual acuity (UCDVA) improved from 0.93 ± 0.096 to 0.18 ± 0.022 (P < .001). Best spectacle-corrected intermediate visual acuity (DSCIVA) was 0.17 ± 0.025, and uncorrected intermediate visual acuity (UCIVA) was 0.27 ± 0.040. Residual regular astigmatic refractive error was 0.21 ± 0.047 D.
Conclusions: The toric DFT/DATx15 EDOF lens showed excellent rotational stability and effective and predictable correction of astigmatism. Its refractive outcomes and safety profile were similar to those identified in prior studies of the non-toric DFT/DAT015 EDOF IOL. A small difference in monocular BSCDVA, of uncertain clinical significance, was found when comparing these outcomes with prior DFT/DAT015 data. The trial was retrospectively registered on November 5, 2021 (TRN ​​NCT05119127).
Speech and music recruit frequency-specific distributed and overlapping cortical networks
Authors: Rietmolen Noemie te , Mercier Manuel , Trebuchon Agnes , Morillon Benjamin , Schon Daniele
Published: October 2022

To what extent do speech and music processing rely on domain-specific and domain-general neural networks? Adopting a dynamical system framework, we investigate the presence of frequency-specific and network-level selectivity and combine it with a statistical approach in which a clear distinction is made between shared, preferred, and category-selective neural responses. Using intracranial EEG recordings in 18 epilepsy patients listening to natural and continuous speech and music, we show that the majority of focal and network-level neural activity is shared between speech and music processing. Our data also reveal an absence of regional selectivity. Instead, neural selectivity is restricted to dis- tributed and frequency-specific coherent oscillations, typical of spectral fingerprints. Our work addresses a longstanding debate and redefines an epistemological posture on how to map cognitive and brain functions.
A importância do acompanhamento psicológico durante o pré-natal em um hospital universitário: um relato de experiência
Authors: BENTO Luciana Cardoso , SIMÃO Guilherme Faquim , ALMEIDA Rodrigo Cesar de
Published: October 2022

A gestação é um período marcado por muitas mudanças na vida da mulher, tendo o contexto de vulnerabilidade social associado a alterações emocionais, assim como a falta de planejamento da gestação. O objetivo deste trabalho é relatar a vivência de uma acadêmica de psicologia no ambulatório de Ginecologia e Obstetrícia, além de sinalizar as condições emocionais das gestantes. Trata-se de um estudo descritivo, tipo relato de experiência, realizado nos acompanhamentos de consultas de pré-natal às gestantes em situação de vulnerabilidade social em um hospital geral de ensino na cidade de Uberaba, MG. Os resultados mostram um alto índice de gravidezes não planejadas, além de dúvidas, medos e preocupações. Conclui-se que é essencial um acompanhamento psicológico efetivo às futuras mães durante as consultas de pré-natal, bem como, uma estruturação do atendimento psicológico no hospital, posto que este atendimento foi inédito no referido ambulatório.
Menopause and genitourinary health: optimal support and correction of disorders
Authors: Yakushevskaya O. V.
Published: October 2022

The vulva, vagina, lower urinary tract, and pelvic floor have the same embryonic origin. Thus, all of the abovementioned organs are equally sensitive to estrogen deficiency and menopausal hormone therapy due to expression of the respective receptors. Genitourinary syndrome of menopause (GSM) is a concept first introduced in 2013 to provide a more complete definition of the consequences of estrogen deficiency in urogenital tissues and reflect the full range of vaginal and urinary symptoms that women experience during menopause. The term broadly reflects the condition, which, unlike the older term “vulvovaginal atrophy”, is not limited to a single symptom of dyspareunia and includes women who are not sexually active. The consequences of GSM significantly alter the quality of life of most menopausal women. Some patients with symptoms of vulvovaginal atrophy completely stop their sexual activity (58 %) and avoid sexual intimacy (55%). Various forms of urinary disorders also alter activities of daily living, sleep, sexual activity, and can lead to social isolation and loss of self-respect. Women with recurrent vulvovaginal infection often have to seek medical care. Estrogen therapy during menopause is pathogenetically justified. Estrogens administered intravaginally are more effective in relieving the symptoms of GSM, both objectively and subjectively, than their systemic use. Up to 40% of women receiving systemic menopausal hormone therapy do not have the expected effect of estrogens on the urogenital tract. If the symptoms of GSM prevail, it is advisable to consider monotherapy with local estrogens or combine it with systemic therapy instead of increasing a dose of the latter. The article presents a clinical case of a personalized approach to solving the issue of vulvovaginal atrophy combined with a mixed urinary incontinence (MUI) in a postmenopausal female patient.
The role of micronutrients in maintaining women’s reproductive potential reduced due to infectious diseases
Authors: Syrkasheva A. G. , Lisitsyna O. I.
Published: October 2022

The human immune system, which is in close connection with other organs and systems including the reproductive one, is required for the body’s defence against infections, as well as other external and internal factors. A balanced diet with a sufficient content of not only macro-, but also micronutrients is necessary for the normal function of the immune system. Various studies showed a relationship between the deficiency of various vitamins and trace elements and decreased activity of the immune system. Thus, the immune response can be impaired by malnutrition and trace element deficiency, which increases the body’s susceptibility to infectious factors. In its turn, the infectious process can lead to an increased demand for micronutrients, which is met by exogenous substances, and in case of not enough consumption of them – by endogenous reserves. Infections are one of the main factors deteriorating human reproductive health. Pelvic inflammatory diseases (PID) hold leading positions in the gynecological pathology pattern, and their prevalence does not show a downward trend. This literature review considers the impact of major infections on women’s reproductive health, presents data on the role of micronutrients in preventing infectious diseases and rehabilitating after them, as well as in preserving reproductive functions after infections. The importance of vitamin C, E, B vitamins, zinc, L-arginine for the preservation and restoration of women’s fertility is considered, and the results of studies on the issue are presented.
Influence of pre-gravid preparation on the course and outcomes of the pregnancy in genital herpes
Authors: Mikhailova O. I. , Kan N. E. , Mirzabekova D. D. , Tyutyunnik V. L.
Published: October 2022

Introduction. According to researchers from different countries, the incidence of neonatal herpes varies noticeably.   Objective. Optimization of pre-gravid preparation of women with chronic recurrent genital herpes to reduce pregnancy complications and improve perinatal outcomes.   Мaterials and methods. The study included 58 women with confirmed chronic recurrent genital herpes. Two groups were formed, the main group included 30 women receiving pre-gravid preparation, complex treatment with antiviral and immunomodulatory drugs, the comparison group was represented by 28 women receiving pre-gravid preparation and only antiviral drug. Evaluation of the effectiveness of the treatment of chronic genital herpes and the benefits of pre-gravid preparation were carried out by assessing clinical manifestations, determining the immune status, analyzing the characteristics of the course of pregnancy, childbirth, and perinatal outcomes.

   Results. As a result of the study, the available data confirm the feasibility of using complex therapy in the treatment of chronic recurrent genital herpes in combination with pre-gravid preparation.   Conclusion. Pre-gravid preparation and specific treatment of women with chronic recurrent genital herpes improve the clinical status of patients, increase the interrecurrent period, reduce the severity of prodromal symptoms, the duration and intensity of relapses of the disease, and contribute more favorable course of pregnancy and improvement perinatal outcomes.
Alternative and complementary correction of menopausal disorders
Authors: Averkova V. G. , Yakushevskaya O. V.
Published: October 2022

Menopause, defined as the cessation of menses for 12 months and more, is a multidimensional evolutionary process, which has a considerable impact on the women’s quality of life and the risk of development of age-associated pathology. 47 million of women around the world enter the menopausal period each year. The menopause onset age is the most important factor which determines the woman health status and, to a large extent, both the risk of morbidity and mortality. Menopause may be induced by a surgical intervention, chemotherapy, and radiation therapy. Post-menopause period accounts for about onethird of a woman’s life and is quite often accompanied by the development of different symptoms associated with estrogen deficiency. Vasomotor symptoms (VMS) are primarily referred to the initial manifestations of the climacteric syndrome. VMS frequency prevails within the two-year period immediately before and after the last menstruation. In some patients, hot flashes can begin long before (10 years prior to) the menopause and persist for a long time. Night sweats, dysphoric disorders, urogenital atrophy / urination disorders, sexual (decreased libido) and cognitive changes, and sleep disturbances are often observed due to the estrogen deficiency. MHT should be considered as a first line therapeutic intervention for the correction of climacteric disorders and prevention of age-associated pathology in women with premature ovarian failure and in menopausal women under the age of 60. For patients who are wary of hormonal therapy or have absolute / relative contradictions to the use of MHT, alternative methods of menopausal disorders correction, which include nonpharmacological and pharmacological non-hormonal drugs with different degrees of efficiency and safety should be considered. Phytoestrogens have confidently filled a niche of alternative therapy for the treatment of menopausal disorders.
Antiproliferative effects of resveratrol and indole-3-carbinol in HPV-associated diseases prevention
Authors: Gusakov K. I. , Nazarova N. M. , Abakarova P. R. , Tararykova A. A. , Ivanov I. A.
Published: October 2022

The burden of persistent papillomavirus infection on public healthcare is not limited to cervical cancer (CC). At present, cervical cancer continues to be one of the most common types of cancer worldwide, although HPV also causes anogenital warts. As there is no HPV treatment available, nowadays researchers focus on the search for new therapeutic platforms, new agents for HPV-associated diseases relapse prevention after surgical treatment. Significant anticancer effects of resveratrol have been demonstrated in a variety of cancers, including breast cancer, skin cancer, lung cancer, pancreatic cancer, and stomach cancer. In CC cells, resveratrol stimulates apoptosis of cancer cells, increases expression of HPV E6 and E7, and the expression of p53 tumor suppressor protein. Protective effects on CC cells migration and invasion is achieved by inhibiting NF-κB transcription and AP-1 mediated MMP9 expression. Resveratrol demonstrates a whole range of anti-inflammatory effects, ranging from the suppression of the pro-inflammatory cytokines IL-1α, IL-1β, IL-6, IL-17 expression and inflammatory mediator prostaglandin E2, to the suppression of the formation of ROS and NO. I3K has a proven antitumor efficacy based on the molecular mechanisms of pathological cell proliferation and tumor transformation in hormone- dependent tissues, including cervical epithelial cells. Resveratrol and I3K have a wide range of studied positive therapeutic effects that can significantly reduce the likelihood of development and progression of HPV-associated lesions.
Inosine pranobex in the treatment of mild cervical intraepithelial neoplasia (experience of clinical use)
Authors: Borovikov I. O. , Kutsenko I. I. , Bulgakova V. P. , Gorbulina A. A.
Published: October 2022

Introduction. The article reflects the experience of treating patients with papillomavirus- associated lesion of the cervix – mild cervical intraepithelial neoplasia (CIN I) with the use of an immunostimulant with antiviral activity – inosine pranobex (tablets 500 mg) with an assessment of clinical and microbiological efficacy.   Aim. Evaluation of the effectiveness of immunomodulatory and antiviral therapy in patients with mild cervical intraepithelial neoplasia with a drug containing inosine pranobex.   Materials and methods. An analysis of treatment with a drug containing inosine pranobex (tablets 500 mg) of 78 women with CIN I (36 months of monitoring) was carried out. Methods: colposcopy, histological examination of biopsy specimens of cervical areas, Pap-test, PCR HPV (qualitative and quantitative), immunohistochemical (determination of markers p16ink4D, Ki-67).   Results. Presented experience of therapy with three-year monitoring of patients diagnosed with CIN I am using an oral immunostimulant with antiviral activity – inosine pranobex – (1000 mg 3 times a day for 28 days 1 time per year, showed its high clinical (84.2 %) and microbiological (83.3 %) efficacy with satisfactory tolerability of the drug.

   Сonclusion. Immunotropic and nonspecific antiviral monotherapy with an oral inosine pranobex drug showed high clinical (recovery of colposcopic status – 83.3 %, cytohistologically confirmed absence of CIN in cervical scrapings – 85.9 %) and microbiological (PCR-negative HPV – 83.3 %) efficacy during the three-year monitoring.
Features of eating behavior in women: experience of observation with an assessment of the risk of predicted complications
Authors: Shevlyukova T. P. , Mateykovich E. A. , Ermakova P. A. , Ermakova A. A.
Published: October 2022

Introduction. Studies show that up to 8 % of pregnant women suffer from eating disorders. Such problems are found everywhere, most often women do not even realize that this may be related to problems. And for pregnant women, this issue is most relevant, since there is a risk of complications of the gestation period, after which it is necessary to prevent unfavorable variants of the course of pregnancy and childbirth.   Aim. To study the variants of eating disorders in pregnant women to assess the prognosis of pregnancy.

   Materials and methods. We conducted a retrospective analysis of clinical case histories of pregnant women (n = 267), followed by a survey of women on the basis of the State Medical Institution “Maternity Hospital No. 2” in Tyumen. The study period is from 2019–2022. Two groups were identified for the analysis: 1st  – BMI of 18.5–24.9 kg/m2 : 2nd  – BMI of 25 kg/m2  or more. In order to determine the type of eating disorder, we used various versions of questionnaires.   Results. Of the total number of women surveyed, overweight (BMI) was determined in 149/267 (55.9 %, 2 group), in 118/267 (44.1 %, 1 group), BMI was within normal values. Risk factors were identified for the groups that could affect the course of the gestational process in the case of an identified eating disorder. When assessing comorbidity, gynecological diseases were detected, pathologies were significantly more common for group 2 62/149 (41.6 %). The dependence of the presence of a violation of any type of eating behavior and the risk of possible complications of pregnancy is not statistically significant.

   Conclusions. To maximize the favorable course of pregnancy and reduce the risk of possible complications, it is necessary to prepare a plan of preventive measures, which will include nutrition planning with a detailed description of solutions for a certain type of eating disorder.
Denazification and the Following Development of Criminal Procedure Law in Western and Eastern Germany Between 1945 and 1990
Authors:   Martin Luther University Halle-Wittenberg (MLU), Zazulin А.I.
Published: October 2022

The process of development of German criminal procedure law in the period from the moment of the end of the World War II (1945) until the moment of unification of Germany (1990) is analyzed within the frameworks of this article. The mentioned time frame is highly important for studying the history of the criminal proceeding of foreign countries because, firstly, its essential feature is denazification of the legislature and, secondly, the existence of two different variants of criminal procedure law (that of the Federal Republic of Germany and German Democratic Republic. However, there are almost no researches of this period in our scientific literature. The author of the article, using German scientific sources, discloses the ways of how German criminal procedure law got rid of the legacy of the national socialism. The author also reviews and compares the changes that happened in the researched area of law in the period of «existence of the two Germanys». As a result of this analysis the author concludes that denazification of the criminal procedure law in Germany was executed by one common way from 1945 until 1949. Further social and political controversies that led to the forming of East and West Germany resulted in different development of this field in these two countries while the common frequency of the reforms was the same in both countries. Where West Germany chose the way of reforming the original criminal procedure law of 1879, East Germany designed a new criminal procedure law. Further development of the procedure in East Germany was connected to liberalization and the struggle with left radicalism and victimization. Meanwhile West Germany chose the acceptance of the Soviet procedure model forgetting many traditional institutions intrinsic to Germany legal proceeding. Based on these findings, the author distinguishes between stages of development of German criminal proceedings in the researched period. The author also suggests to divide it into periods.
AVALIAÇÃO PÓS-OCUPAÇÃO (APO) APLICADA EM UM AMBIENTE ADMINISTRATIVO NO INTERIOR DE PARQUE FABRIL AUTOMOBILÍSTICO
Authors: ACCIOLI MARTA ELISA RIEKSTIN , ORNSTEIN SHEILA WALBE
Published: October 2022

O artigo foi resultante de uma pesquisa de mestrado desenvolvida e concluída junto ao Programa de Pós-Graduação da Faculdade de Arquitetura e Urbanismo da Universidade de São Paulo, com o objetivo de investigar as decisões de projeto adotadas, e seus resultados, em um ambiente de escritórios inserido em um edifício administrativo de um parque fabril automobilístico. O edifício estudo de caso elegido para a pesquisa, construído em 1985, possui cerca de 13.500m² de área útil e, em 2015, passou por um processo de retrofit interno, com renovação nos seus conceitos de ocupação e com novas configurações dos seus ambientes. As investigações foram realizadas por meio da aplicação dos instrumentos indicados nos procedimentos metodológicos da Avaliação Pós-Ocupação (APO), reunindo um conjunto amplo de métodos e técnicas (quantitativos e qualitativos), de forma a explorar os instrumentos, sob o ponto de vista do especialista, e as experiências e necessidades dos usuários. O trabalho conduziu a um diagnóstico sistêmico, com o entendimento das soluções implantadas, apresentando possíveis melhorias para os espaços avaliados e servindo de subsídios para arquitetos, facilities managers e gestores, na realimentação de projetos futuros semelhantes e na gestão dos ambientes de trabalho, especialmente no caso deste estudo, mas com potencial de contribuições para outros estudos de caso afins.
 
PALAVRAS-CHAVE: avaliação pós-ocupação; escritórios; parque fabril
Is There Any Collaborative Governance on Post-disaster Social Policy in Banten Province?
Authors: Thahir Baharuddin
Published: October 2022

Social policies include increased social protection, approaches to improving living standards, and access to decent work. The description discusses two concepts, namely collaborative governance and the concept of social policy. Methodologically and technically, the two concepts are side by side in the context of implementing decentralization policies. Collaborative governance as collaboration is a relationship designed to solve a problem through the creation of solutions in conditions that are full of limitations  (Ansell & Gash, 2008). At the same time, the social policy responds to social problems, which tends to ignore the assessment of some people that they are not in a socially problematic condition (Spicker, 2014). social policy has many forms, such as health, education, housing, and other social services. The method uses a descriptive qualitative and qualitative verification analysis strategy model. Post-disaster handling, collaborative governance is applied through the government's efforts to carry out recovery that focuses on the residential, economic, infrastructure, social and cross-sectoral sectors. The results also show obstacles in collaborative governance, such as delays in building houses for the community, mismatch of specifications between what was promised and what was received by the community, and low public understanding. This study also shows that post-disaster management collaborative governance can be implemented using several strategies divided by sector and sub-sector; the right communication pattern increases community involvement in the entire post-disaster management process in Banten province. All strategies would be better if packaged in the form of government innovation. This means that post-disaster management, especially in repair and development efforts, is an important agenda for government collaboration.
E-Wallet use in Concert Ticket Purchase: The efficiency, security, and satisfactory
Authors: Shahrom Syrul Azlan , Zakaria Juwairiyah , Wincci Soo
Published: October 2022

Due to the evolution of financial technology in recent years, the number of E-wallet cashless transactions has increased significantly. Payment services have grown increasingly significant in Malaysians' everyday life with the introduction of E-wallets in the country, owing to a variety of planned and accidental occurrences. The goal of this research is to discover the efficiency, security, and satisfaction of E-wallet use in concert ticket purchases. The objectives of this study are to analyze the effectiveness of E-wallets in concert ticket purchasing and to investigate the impacts of E-wallet usage in the music business. The methodology used in this research is the SWOT analysis. The finding reveals that the use of an E-wallet is efficient (saves energy and cost) and (attracts and expands the marketability of ticket sales.). With a low level of risk, an e-wallet has more excellent protection and increases the level of security. Online purchasing satisfies the buyers with valuable benefits and rewards, as well as improves consumers' budgeting. The use of E-wallets generates income for musicians as well as contributes to the reform of the system in the business of buying and selling in the Malaysian music industry.
Exploration and Reflection of Online Piano Teaching Practice in Normal Universities in China
Authors: Yuchen Liao , Yoong Chong Yew
Published: October 2022

At the beginning of 2020, due to the sudden outbreak of COVID-19, education in China was disrupted. The Chinese government has strongly supported online education, while the music education industry has also adopted a "Suspension of class but no suspension of learning" plan. Universities have also carried out online classroom practices, which has also opened a new door to online piano teaching in universities in China. The feasibility of online piano teaching in daily classrooms of universities in China is something worth researching.
Trusted Data Spaces as a Viable and Sustainable Solution for Networks of Population-Based Patient Registries
Authors: Nicholson Nicholas , Caldeira Sandra , Furtado Artur , Nicholl Ciaran
Published: October 2022

Harmonization and integration of health data remain as the focus of many ongoing efforts toward the goal of optimizing health and health care policies. Population-based patient registries constitute a critical element of these endeavors. Although their main function is monitoring and surveillance of a particular disease within a given population, they are also an important data source for epidemiology. Comparing indicators across national boundaries brings an extra dimension to the use of registry data, especially in regions where supranational initiatives are or could be coordinated to leverage good practices; this is particularly relevant for the European Union. However, strict data protection laws can unintentionally hamper the efforts of data harmonization to ensure the removal of statistical bias in the individual data sets, thereby compromising the integrated value of registries’ data. Consequently, there is the motivation for creating a new paradigm to ensure that registries can operate in an environment that is not unnecessarily restrictive and to allow accurate comparison of data to better ascertain the measures and practices that are most conducive to the public health of societies. The pan-European organizational model of cancer registries, owing to its long and successful establishment, was considered as a sound basis from which to proceed toward such a paradigm. However, it has certain drawbacks, particularly regarding governance, scalability, and resourcing, which are essential elements to consider for a generic patient registry model. These issues are addressed in a proposal of an adapted model that promises a valuable pan-European data resource for epidemiological research, while providing a closely regulated environment for the processing of pseudonymized patient summary data on a broader scale than has hitherto been possible.
Clinical Utility of a Digital Therapeutic Intervention in Indian Patients With Type 2 Diabetes Mellitus: 12-Week Prospective Single-Arm Intervention Study
Authors: Chawla Rajeev , Jaggi Shalini , Gupta Amit , Bantwal Ganapathi , Patil Suhas
Published: October 2022

Background

Patients with type 2 diabetes mellitus (T2DM) having elevated levels of blood glucose and glycated hemoglobin (HbA1c) are at higher risk of macro- and microvascular complications. Nonetheless, the goal of achieving glycemic control cannot be met with the use of pharmacotherapy alone. The recent emergence of digital therapeutic tools has shown the possibility of improving the modifiable risk factors and self-management of diabetes.

Objective

The aim of this study was to examine the clinical utility of a digital therapeutic intervention as an add-on therapy to achieve glycemic control in patients with T2DM.

Methods

This was a 12-week prospective, single-arm digital intervention study in patients with T2DM receiving regular antidiabetic treatment. The eligibility criteria included male and female patients with HbA1c≥6.5%, functional English literacy, and a mobile phone capable of running the intervention app. Outcome measures of the study were mean changes in HbA1c, fasting blood glucose (FBG), postprandial blood glucose (PPBG), BMI, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) index at the end of 12 weeks.

Results

A total of 128 participants completed the study period of 12 weeks. There were 54.7% (70/128) men and 45.3% (58/128) women with a mean age of 48.48 years (SD 10.27). At the end of 12 weeks, the mean change in HbA1c, FBG, PPBG, and BMI for the overall study population was –0.84% (P<.001), –8.39 mg/dl (P=.02), –14.97 mg/dl (P<.001), and –0.24 kg/m2 (P=.06), respectively. Among the participants showing improvement in the HbA1c value at the end of 12 weeks (responders), the mean change in HbA1c, FBG, PPBG, and BMI was –1.24% (P<.001), –12.42 mg/dl (P=.003), –21.45 mg/dl (P<.001), and –0.34 kg/m2 (P=.007), respectively. There was an increase in HOMA-IR values for the overall study population (0.54, P=.29). HbA1c response showed a significant association with a baseline HbA1c level ≥7.5%, no prior history of smoking, and no prior COVID-19 infection, as well as with higher levels of program engagement.

Conclusions

A digital therapeutic intervention when used alongside standard medications significantly reduces HbA1c, FBG, and PPBG levels in patients with T2DM.
Diagnostic accuracy of screening instruments used to detect postpartum depression among women of reproductive age in the primary care setting : A protocol for a systematic review and meta-analysis (Preprint)
Authors: Andriani Russy Novita , Makkiyyah Siti Solichatul , Hertika Amanda Safira Dea , Istiono Wahyudi , Hakimi Mohammad
Published: October 2022

BACKGROUND

Postpartum depression (PPD) is a common condition of the postpartum period that affects the mother's and child's well-being and functioning. Half of women with postpartum depression (PPD) do not obtain therapy due to inadequate access. The patient's primary and continuing point of care is primary care. Despite the controversy surrounding screening and early detection in primary care settings, many PPD cases remain undetected. Due to the vagueness of this topic, screening tools must be able to detect situations.

OBJECTIVE

This study aim to identify the best postpartum depression screening tool for use in primary healthcare among women of reproductive age.

METHODS

This protocol follows the Preferred Reporting Items for Systematic Review and Meta-Analysis of Protocols (PRISMA-P) statement. There will be access to the databases ClinicalTrials.gov., PubMed, ScienceDirect, ProQuest, and EBSCO between January 2010 and September 2022, but only in English. Two reviewers will identify articles separately by reviewing article titles, abstracts, and full texts. Consensus will be used to settle any disagreements. Quality Assessment of Diagnostic Accuracy Studies (QUADAS) will be used to assess the quality and potential for bias. Extraction of data and content analysis will be conducted methodically. Using a forest plot with 95% confidence intervals, quantitative data will be represented graphically. The summary receiver operating characteristic curve will describe the diagnostic test's outcome. Review Manager 5.3 (Rev Man 5.3) will be applied in order to assess the data.

RESULTS

We predict that the majority of primary studies will simply use one piece of information for each woman. However, we anticipate that a small number of studies will offer information for multiple time points. Positive and negative predictive value values, which are more clinically relevant, will be derived using the sensitivity and specificity estimates obtained from the analyses. The suggested systematic review and meta-analyses will enable us to identify the best postpartum depression screening instrument for primary care use.

CONCLUSIONS

Many PPD cases remain undetected despite the controversy surrounding screening and early identification in primary care settings. Given the ambiguity surrounding this issue, screening tools must be effective at identifying cases. Therefore, we proposed the study to determine the accuracy of various screening instruments used in primary care to identify postpartum depression. These results can help guide future research and clinical objectives to better detect and treat maternal depression.

CLINICALTRIAL

Systematic review registration: PROSPERO CRD42020216067
Cultural-Artistic Value in Epic and Festival of the Muong Thanh Hoa People
Authors: Dung Vu Thi
Published: October 2022

The epic The Land of the Earth is a system of mythical stories about the formation of heaven and earth of the Muong. It is also considered history and an encyclopedia of the customs of the Muong people. This epic is both pride and respect in the cultural life of the Muong community. This article studies several outstanding cultural symbols of the epic "Land for the Land" which have been preserved and remained quite intact in the Poon Poong festival - one of the most important festivals of the Muong people in Thanh Hoa.
IWB/EFRE-OP AT 2014-20 Begleitende Evaluierung Leistungspaket 2: Kleine und mittlere Unternehmen (KMU) – Endbericht
Authors:   KMU Forschung Austria, Kaufmann Peter , Dorr Andrea , Enichlmair Christina , Hosner Daniela , Mollay Ursula , Robubi Arash , Zlatev Tatjana
Published: October 2022

Diese Studie wurde im Rahmen der begleitenden Evaluierung des IWB/EFRE AT 2014-2020 erstellt. Sie konzentriert sich auf die Prioritätenachse 2, „Stärkung der Wettbewerbsfähigkeit von kleinen und mittleren Unternehmen“ und zielt auf die Analyse der Konzeption, Umsetzung, Zielerreichung und die Wirkungen ab. Methodisch basiert die Studie auf dem Ansatz der theoriebasierten Evaluation, indem eine empirisch und konzeptionell fundierte Interventionslogik und maßnahmenspezifische Wirkungsmodelle entwickelt wurden. Auf dieser Basis werden unterschiedliche qualitative und quantitative Methoden der empirischen Sozial- und Wirtschaftswissenschaften eingesetzt, um die unterstellten Annahmen und Wirkungsmechanismen zu überprüfen. Das IWB/EFRE-Programm versteht sich als ergänzendes Instrument im nationalen und regionalen Förderspektrum. Die Fördergebiete umfassen das gesamte Bundesgebiet, für die in der Periode 2014-2020 ein Budget von € 536,26 Mio. zur Verfügung steht. Die Finanzmittelallokation pro thematischem Ziel sowie die Höhe des nationalen Beitrags („Kofinanzierungssatz“) variieren jedoch, da das Burgenland als Übergangsregion eingestuft wird, während die anderen Bundesländer zu den stärker entwickelten Regionen zählen.
Disciplinar cuerpos, normalizar ciudadanos. Ensayos sobre la deportivización de Chiapas tras la Revolución mexicana
Authors:   CIMSUR - UNAM, Lisbona Guillén Miguel
Published: October 2022

La Revolución mexicana en tierras chiapanecas se ha observado, en muchos casos, desde la ausencia de modernización. Anhelo de instituciones que cumplieran el compromiso político del Estado, aunque ello haya evitado mirar la extensión de dicho Estado a través de asentar la nación en forma de mexicanización del territorio chiapaneco. Escribir sobre la educación física y el deporte en Chiapas es un reto académico que apunta a una parte de ese proceso de extensión del Estado gracias a la idea de transformar prácticas y hábitos de la población, especialmente la indígena y campesina. Romper los hábitos del pasado no es un simple discurso, sino que debía reflejarse en acciones que involucran los cuerpos de los ciudadanos con la finalidad de construir una nación homogénea en lo físico y lo cultural. Discurso y logro de objetivos no siempre son coincidentes; sin embargo, los años posrevolucionarios muestran la efervescencia de ideas sobre la regeneración física y la higienización social de prolongado aliento en la sociedad chiapaneca.
Credit Card Fraud Detection Using Hybrid Machine Learning Algorithms
Authors: Chaturvedi Parth , Mishra Suraj , Agrawal Suraj
Published: October 2022

Abstract: Credit cards have a high frequency of transactions taking place daily. There are approximately 36.4 percent fraud related to commercial cards which include credit card, debit card, etc. In 2022 there are 64 million people who use credit cards to initiate the transaction, therefore they are also prone to card fraud. To evaluate the model efficacy, a publicly available credit card data set is used. Investigation on different hybrid algorithms for the given dataset were studied. This research investigates seven different hybrid machine learning models to detect fraudulent activities. Our findings indicated that the hybrid model of Adaboost and LGBM is the most efficient model due to its high performance.
Formulation and Evaluation of Floating Tablets of Pantoprazole
Authors: Vinod M , Chetankumar M , Bote Somanath , Kolageri Shivanand
Published: October 2022

Background: Pantoprazole is a protein pump inhibitor (PPI) used to treat acute duodenal ulcers, acute benign gastric ulcers, gastroesophageal reflux disease (GERD), and as a preventative measure for duodenal ulcer. It has a local effect on the stomach and works by competitively inhibiting the enzyme H+/K+ ATP, which is found in the gastric parietal cells. For acute duodenal ulcers, acute benign gastric ulcers, and gastroesophageal reflux disease (GERD), the usual oral dosage recommendation is 45 mg, and it is taken for 8–12 weeks. 

Objectives: The preparation of pantoprazole floating tablets was attempted in the current investigation and optimize the formulation using different excipients like Hydroxy ethyl cellulose (HEC), cyclodextrin, sodium bicarbonate, citric acid and microcrystalline cellulose were used in the direct compression method to create pantoprazole floating tablets (250 mg).

Methods: The direct compression method has been used in the current effort to create floating tablets. The active ingredient, sodium bicarbonate, citric acid, microcrystalline cellulose, and hydroxy ethyl cellulose were sieved through sieve no. 60 and blended uniformly with a mortar and pestle. Using a Rotary tablet punch machine, the powder was compacted into tablets after talc and magnesium stearate were added as lubricants

Results: Preformulation studies were conducted to select suitable excipients, drug/polymer interactions were validated by the FTIR investigation. The manufactured floating tablets were assessed for hardness, weight fluctuation, thickness, friability, drug content homogeneity, floating lag time, and in vitro dissolution experiment studies was conducted. The results were within the limit and were compared with the marketed formulation.

Conclusion: According to the observations of the current investigation, a floating pantoprazole tablet increases the stomach residence time and bioavailability, increasing therapeutic efficacy. Formulations F1, F2, F4, F5, F7, and F8 showed good floating, but Formulations F3, and F6 showed moderate floating throughout all 8 formulations. The stability analyses that were done for all the formulations showed that the F7 and F8 formulations had good stability.

Keywords: Pantoprazole, Floating tablet, Hydroxy ethyl cellulose (HEC), Cyclodextrin, In-vitro drug release studies.
Reformulation and Scientific Evaluation of CUSOCO: A Traditional Toothpaste Formula from Classical Tamil Literature towards treatment of Halitosis
Authors: Chandran M. , Priyanka R. , Kavipriya D. , Ramya S. , Jayakumararaj R. , Loganathan T. , Pandiarajan G. , Kaliraj P. , Grace Lydial Pushpalatha G , Abraham GC. , Dhakar Ram Chand
Published: October 2022

In order to achieve the multi-claim products required for dental-health-care and hygiene, it is indispensable for the formulator to use a wide range of ingredients however, with the advent of technology the chemically synthesised products are not of demand in the market as they have side effects and are considered to unsafe for human use. This places quite a number of demands on the use of PBNPs in the development process. Use of PBNPs innovations in the areas of pharmaceutical technology have contributed significantly to the formulation of dental-health-care products with superior efficacy as well as other attributes that may contribute to clinical response and patient acceptability. Improved clinical efficacy and tolerability, along with conditioning signals, should encourage patient compliance with oral hygiene. Cuminum cyminum seeds are being habitually used in traditional cuisines of different cultures. In India, it is used in both whole and ground form as a traditional ingredient to make dishes without perceptive medicinal knowledge/ properties behind. In Kerala, decoction of cumin seeds is used for drinking (Jeera water). In Tamilnadu, cumin seeds are the key ingredient of Rasam. Fruit of Solanum lycopersicum is one of the important savoury vegetable used in traditional Indian cuisines. The oil of Cocos nucifera fruits are used in cooking in Kerala and TamilNadu. In the present study, composition (paste) prepared by mixing of 2 drops of S. lycopersicum fruit juice, 2 drops of C. nucifera and 1g of C. cyminum seed powder were tested on 100 subjects with felt bad breath. Results of the present study was found to be effective in controlling bad breath (odour) in 74 subjects after the treatment (period of clinical trial) except 09 of 83 subjects who were diabetic.

Keywords: Oral hygiene; bad breath; halitosis; Cuminum cyminum; Solanum lycopersicum; Cocos nucifera; CUSOCO; dental-health-care
Phenytoin Induced Cerebral Atrophy: A Case Report
Authors: Linggi Celeste , Mathews Anit , Mopidevi Rasi , Nyamagoud Sanat Kumar B. , D.S. Usha
Published: October 2022

Phenytoin is the most common drug prescribed in patient diagnosed with seizure. Cerebral atrophy is an observed complication in phenytoin exposed patients. The side effects related to phenytoin administration include sedation, dizziness, swaying, rash and gum hypertrophy. In the following case report a 50-year-old male patient with complaints of poor response to oral commands, slurred speech, limited upper limb movements and neck rigidity, the patient is a known epileptic since 1 year on prescription and is alcoholic. Upon CT scan of brain, the impression was mild diffuse cerebellar atrophy probably due to long term phenytoin use. Hence frequent phenytoin level monitoring in patient prescribed with the same is mandatory.

Keywords: phenytoin, epilepsy, cerebral atrophy
Variables asociadas a la violencia digital de pareja en una muestra de adultos jóvenes de Yucatán, México, entre el 2015 y 2020
Authors: Euan Catzín Aarón Javier , Pinto Carrillo María Fernanda
Published: October 2022

Este estudio identifica aspectos sociodemográficos y del tiempo de uso del internet que se asocian a la violencia digital de pareja, así como las diferencias sobre los tipos de violencia digital y las redes sociales donde ocurre. A través de un estudio observacional de alcance correlacional, se seleccionaron 340 casos de la base de datos de la Primera Evaluación de la Violencia Digital en Yucatán y se tomaron reactivos que medían las variables de interés. En los resultados se encontró que la vigilancia (α: <.001; OR: 1.607), el correo electrónico (α: .033; OR: 2.787) y usar internet 1 o 2 días a la semana (α: .02; OR: 1.5217), se relacionan a la violencia digital de pareja. El flaming (α: .013; OR: .405) y las burlas y acoso (α: .001; OR: .371) se asociaron a otros ámbitos de violencia digital. También se observó que la comunidad LGBTTIQ, las mujeres y quienes pasan menos tiempo en internet, viven más violencia digital de pareja que sus contrapartes. Se concluye que la violencia digital presenta elementos particulares y diferencias según el tipo de violencia experimentada. La elevada prevalencia en ambas modalidades sugiere patrones de interacción violenta en esta población, resaltando la necesidad de intervenciones que atiendan esta problemática.
publicaciones científicas de la Policía Nacional
Authors: Aparicio Juan
Published: October 2022

Entre los años de 1966 y 2007 las publicaciones en educación de la Policía Nacional se realizaron a través de la Imprenta del Fondo Rotatorio de la Policía Nacional; con la liquidación de la misma, las Direcciones, Oficinas Asesoras y las Escuelas recurrieron al monopolio público de la Imprenta Nacional de Colombia o empresas privadas de acuerdo al tipo de publicación o impreso. Esta situación, repercutió a la dispersión de las publicaciones de divulgación y científicas de la Policía Nacional.