bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplemental Figure S2 from CRMP5 Controls Glioblastoma Cell Proliferation and Survival through Notch-Dependent Signaling
Authors: Moutal Aubin , Honnorat Jérôme , Massoma Patrick , Désormeaux Pauline , Bertrand Caroline , Malleval Céline , Watrin Chantal , Chounlamountri Naura , Mayeur Marie-Eve , Besançon Roger , Naudet Nicolas , Magadoux Léa , Khanna Rajesh , Ducray François , Meyronet David , Thomasset Nicole
Published: April 2023

CRMP1-5 mRNA expressions do not predict patients survival in glioblastoma using a subset of TCGA GBM cohort (N=173). (A): Comparison of CRMP1-5 mRNA levels among GBMs of patient with different survival. No significant difference in mRNA levels was observed in GBMs from long survivors (Survival > 33 months, N=35) to patients with normal survival (<29 months, N=138 for DPYSL1 (CRMP1) (p=0.150), DPYSL2 (CRMP2) (p=0.801), DPYSL3 (CRMP4) (p=0.533), DPYSL4 (CRMP3) or DPYSL5 (CRMP5) (p=0.359). (B-F) : Kaplan-Meier survival analysis of GBM patients with regards to CRMP1-5 mRNA expression levels; log-rank test. No survival difference was found between patients with highest levels mRNA expression compared to patients with lowest levels for CRMP1 (p=0.685), CRMP2 (p=284), CRMP3 (p=0.071), CRMP4 (p=0.053) or CRMP5 (p=0.388). (G-H): CRMP5 expression patterns by reactive glial cells at the periphery (Blue arrows) (G) : a CRMP5 negative GBM (Yellow star, Alkaline phosphatase chromogen) and (H) : an abscess ( Yellow star, Di-Amino-Benzidine chromogen); Scale bars=100µm.
Supplementary Table 2 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

FISH results regarding the CDKN2A status in chordoma cell lines and the corresponding parental tumor.
Supplementary Figure 2 from Preclinical Characterization of Novel Chordoma Cell Systems and Their Targeting by Pharmocological Inhibitors of the CDK4/6 Cell-Cycle Pathway
Authors: von Witzleben Adrian , Goerttler Lukas T. , Marienfeld Ralf , Barth Holger , Lechel André , Mellert Kevin , Böhm Michael , Kornmann Marko , Mayer-Steinacker Regine , von Baer Alexandra , Schultheiss Markus , Flanagan Adrienne M. , Möller Peter , Brüderlein Silke , Barth Thomas F.E.
Published: April 2023

Inversion microscopy views of the published chordoma cell lines U-CH1, U-CH2, U-CH 3, 6, 7, 10, 11, and 12. The cells showing the typical physaliphorous cytology; bars=100Âµm.
Supplementary Figure S3 from AKT1 and MYC Induce Distinctive Metabolic Fingerprints in Human Prostate Cancer
Authors: Priolo Carmen , Pyne Saumyadipta , Rose Joshua , Regan Erzsébet Ravasz , Zadra Giorgia , Photopoulos Cornelia , Cacciatore Stefano , Schultz Denise , Scaglia Natalia , McDunn Jonathan , De Marzo Angelo M. , Loda Massimo
Published: April 2023

Outlier plots of pathways enriched across three datasets (RWPE-1 cells, MPAKT and Lo-MYC mice, and human prostate tissues). Outliers were detected using (A) box-and-whisker plot (more than 75% of the inter-quartile range away from the box) and (B) by their notable "jump" above/below the rest of the points in the scatterplot. (C) Gene Set Enrichment plots.
Supplementary Figures S1-9, Tables S1 and 2 from Targeting the MDM2/MDM4 Interaction Interface as a Promising Approach for p53 Reactivation Therapy
Authors: Pellegrino Marsha , Mancini Francesca , Lucà Rossella , Coletti Alice , Giacchè Nicola , Manni Isabella , Arisi Ivan , Florenzano Fulvio , Teveroni Emanuela , Buttarelli Marianna , Fici Laura , Brandi Rossella , Bruno Tiziana , Fanciulli Maurizio , D'Onofrio Mara , Piaggio Giulia , Pellicciari Roberto , Pontecorvi Alfredo , Marine Jean Christophe , Macchiarulo Antonio , Moretti Fabiola
Published: April 2023

Supplementary Figures S1-9, Tables S1 and 2. Supplementary Figure S1: Analysis of p53 ubiquitination and binding Supplementary Figure S2: Pep3 activity in human tumor cell lines Supplementary Figure S3: Pep3 activity in untransformed cells Supplementary Figure S4: In vivo Pep3 activity Supplementary Figure S5: Pep3 molecular activity Supplementary Figure S6: Transcriptomic analysis of Pep3 Supplementary Figure S7: Pep3 activity on p53 transcriptional function Supplementary Figure S8: Analysis of BIK and PIG3 knockdown Supplementary Figure S9: Analysis of Pep3-mediated pro-oxidant activity Supplementary Table S1: List of genes differentially expressed between Pep3- and Pep3M- treated HCT116 at 24hrs Supplementary Table S2: List of genes differentially expressed between Pep3- and Pep3M- treated HCT116 at 48hrs
Supplementary Figure S1 from Genetic Disruption of Lactate/H+ Symporters (MCTs) and Their Subunit CD147/BASIGIN Sensitizes Glycolytic Tumor Cells to Phenformin
Authors: Marchiq Ibtissam , Le Floch Renaud , Roux Danièle , Simon Marie-Pierre , Pouyssegur Jacques
Published: April 2023

Figure S1: ZFN-mediated MCT4 and BSG gene knockout.
Supplemental Methods, Figures 1 - 2 from Recommendations for Benchmarking Preclinical Studies of Nanomedicines
Authors: Dawidczyk Charlene M. , Russell Luisa M. , Searson Peter C.
Published: April 2023

Figure S1. Comparison of the dose of different nanomedicines from pre-clinical trials reported in a recent meta-study. Figure S2. Variations in tumor accumulation from 5 pre-clinical trials of nanomedicines in colon adenocarcinoma xenografts (C26).
Supplementary Table 1 from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Table 1. A list of top 200 differentially expressed genes in xenografts from injection of shMFNG MDA-MB231 cells vs. control MDA-MB231 cells
Supplementary Tables 1 - 2 from NOS Inhibition Modulates Immune Polarization and Improves Radiation-Induced Tumor Growth Delay
Authors: Ridnour Lisa A. , Cheng Robert Y.S. , Weiss Jonathan M. , Kaur Sukhbir , Soto-Pantoja David R. , Basudhar Debashree , Heinecke Julie L. , Stewart C. Andrew , DeGraff William , Sowers Anastasia L. , Thetford Angela , Kesarwala Aparna H. , Roberts David D. , Young Howard A. , Mitchell James B. , Trinchieri Giorgio , Wiltrout Robert H. , Wink David A.
Published: April 2023

Supplementary Table 1. Th1 vs. Th2 Cytokine Trend. Supplementary Table 2. Effect of L-NAME on Radiation-induced Cytokine Expression.
Supplementary Information from Manic Fringe Promotes a Claudin-Low Breast Cancer Phenotype through Notch-Mediated PIK3CG Induction
Authors: Zhang Shubing , Chung Wen-Cheng , Wu Guanming , Egan Sean E. , Miele Lucio , Xu Keli
Published: April 2023

Supplementary Information. Including Supplementary Figure Legends, Supplementary Methods, and Supplementary References.
Supplementary Figure S3 from IL6/JAK1/STAT3 Signaling Blockade in Endometrial Cancer Affects the ALDHhi/CD126+ Stem-like Component and Reduces Tumor Burden
Authors: van der Zee Marten , Sacchetti Andrea , Cansoy Medine , Joosten Rosalie , Teeuwssen Miriam , Heijmans-Antonissen Claudia , Ewing-Graham Patricia C. , Burger Curt W. , Blok Leen J. , Fodde Riccardo
Published: April 2023

Supplementary Figure S3. Growth analysis of endometrial cancer cells in the presence/absence of Cisplatin and IL6 pathway inhibitors.
Supplementary Table 1 from Novel Associations between Common Breast Cancer Susceptibility Variants and Risk-Predicting Mammographic Density Measures
Authors: Stone Jennifer , Thompson Deborah J. , dos Santos Silva Isabel , Scott Christopher , Tamimi Rulla M. , Lindstrom Sara , Kraft Peter , Hazra Aditi , Li Jingmei , Eriksson Louise , Czene Kamila , Hall Per , Jensen Matt , Cunningham Julie , Olson Janet E. , Purrington Kristen , Couch Fergus J. , Brown Judith , Leyland Jean , Warren Ruth M.L. , Luben Robert N. , Khaw Kay-Tee , Smith Paula , Wareham Nicholas J. , Jud Sebastian M. , Heusinger Katharina , Beckmann Matthias W. , Douglas Julie A. , Shah Kaanan P. , Chan Heang-Ping , Helvie Mark A. , Le Marchand Loic , Kolonel Laurence N. , Woolcott Christy , Maskarinec Gertraud , Haiman Christopher , Giles Graham G. , Baglietto Laura , Krishnan Kavitha , Southey Melissa C. , Apicella Carmel , Andrulis Irene L. , Knight Julia A. , Ursin Giske , Alnaes Grethe I. Grenaker , Kristensen Vessela N. , Borresen-Dale Anne-Lise , Gram Inger Torhild , Bolla Manjeet K. , Wang Qin , Michailidou Kyriaki , Dennis Joe , Simard Jacques , Pharoah Paul , Dunning Alison M. , Easton Douglas F. , Fasching Peter A. , Pankratz V. Shane , Hopper John L. , Vachon Celine M.
Published: April 2023

Supplementary Table 1. Mean (95% Confidence Interval (CI)) mammographic density measurements by covariate distribution
Supplemental Table 3 from The Cyclic AMP Pathway Is a Sex-Specific Modifier of Glioma Risk in Type I Neurofibromatosis Patients
Authors: Warrington Nicole M. , Sun Tao , Luo Jingqin , McKinstry Robert C. , Parkin Patricia C. , Ganzhorn Sara , Spoljaric Debra , Albers Anne C. , Merkelson Amanda , Stewart Douglas R. , Stevenson David A. , Viskochil David , Druley Todd E. , Forys Jason T. , Reilly Karlyne M. , Fisher Michael J. , Tabori Uri , Allen Jeffrey C. , Schiffman Joshua D. , Gutmann David H. , Rubin Joshua B.
Published: April 2023

Supplemental Table 3. Primer sequences.
Supplementary Figure S3 from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Authors: Sadok Amine , McCarthy Afshan , Caldwell John , Collins Ian , Garrett Michelle D. , Yeo Maggie , Hooper Steven , Sahai Erik , Kuemper Sandra , Mardakheh Faraz K. , Marshall Christopher J.
Published: April 2023

Supplementary Figure S3. Volume of 4599 primary tumour in nude mice treated with AT13148.
Supplementary Figure S1 from Rho Kinase Inhibitors Block Melanoma Cell Migration and Inhibit Metastasis
Authors: Sadok Amine , McCarthy Afshan , Caldwell John , Collins Ian , Garrett Michelle D. , Yeo Maggie , Hooper Steven , Sahai Erik , Kuemper Sandra , Mardakheh Faraz K. , Marshall Christopher J.
Published: April 2023

Supplementary Figure S1. Cell titer Glo-based viability assay melanoma cells treated with CCT129254 or AT13148.
Supplementary Figure S1 from ITGBL1 Is a Runx2 Transcriptional Target and Promotes Breast Cancer Bone Metastasis by Activating the TGFβ Signaling Pathway
Authors: Li Xiao-Qing , Du Xin , Li Dong-Mei , Kong Peng-Zhou , Sun Yan , Liu Pei-Fang , Wang Qing-Shan , Feng Yu-Mei
Published: April 2023

Figure S1. ITGBL1 is highly expressed in primary breast cancer tumors developing bone metastasis, and high ITGBL1 expression levels indicate lower risk of lung metastasis.
Supplementary Figure Legend from TGFβ Is a Master Regulator of Radiation Therapy-Induced Antitumor Immunity
Authors: Vanpouille-Box Claire , Diamond Julie M. , Pilones Karsten A. , Zavadil Jiri , Babb James S. , Formenti Silvia C. , Barcellos-Hoff Mary Helen , Demaria Sandra
Published: April 2023

Supplementary Figure Legend
Fig. S7 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Effects of PAF/PAFR axis on EMT in Calu-3 and H226 cells.
Fig. S5 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

Effects of PAFR inhibitor-WEB2086 on growth and invasion of A549 and H460 cells in vitro.
Supplemental Figure 3 from EGF Receptor Promotes Prostate Cancer Bone Metastasis by Downregulating miR-1 and Activating TWIST1
Authors: Chang Yung-Sheng , Chen Wei-Yu , Yin Juan Juan , Sheppard-Tillman Heather , Huang Jiaoti , Liu Yen-Nien
Published: April 2023

(A) IF staining of RasB1 and PC3 cells with an antibody for EGFR following EGF and CI1033 treatment. Scale bars represent 50 µm. (B) IHC staining of FFPE cell blocks of RasB1 and PC3 cells with an antibody for p-EGFR (Y1068) following EGF and CI1033 treatment. (C) The intensity of total EGFR was normalized to the internal control, histone 3 or β-actin, from Western blots of nuclear and cytoplasmic cell extracts of RasB1 cells following EGF treatment. (D) The intensity of p-ERK1/2 was normalized to total ERK1/2 from Western blots of nuclear and cytoplasmic cell extracts of RasB1 cells following EGF treatment. (E) ChIP analyses of predicted ATRSs in the pri-miR-1-1 promoter region of 22Rv1 cells following EGF treatment. Enrichment of each protein at each site is given as a percentage of the total input and then normalized to each IgG. Data are presented as the mean {plus minus} SEM, n=3. * vs. -EGF. ** p<0.01, *** p<0.001.
Fig. S11 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

PAF/PAFR axis enhanced the strength and duration of Stat3 activation.
Fig. S1 from Feed-Forward Reciprocal Activation of PAFR and STAT3 Regulates Epithelial–Mesenchymal Transition in Non–Small Cell Lung Cancer
Authors: Chen Jie , Lan Tian , Zhang Weimin , Dong Lijia , Kang Nan , Zhang Shumin , Fu Ming , Liu Bing , Liu Kangtai , Zhan Qimin
Published: April 2023

PAFR positively correlates with the progression of various cancers.
Supplementary Table S1 from Breast Cancer Cell–Derived GM-CSF Licenses Regulatory Th2 Induction by Plasmacytoid Predendritic Cells in Aggressive Disease Subtypes
Authors: Ghirelli Cristina , Reyal Fabien , Jeanmougin Marine , Zollinger Raphaël , Sirven Philémon , Michea Paula , Caux Christophe , Bendriss-Vermare Nathalie , Donnadieu Marie-Hélène , Caly Martial , Fourchotte Virginie , Vincent-Salomon Anne , Sigal-Zafrani Brigitte , Sastre-Garau Xavier , Soumelis Vassili
Published: April 2023

Supplementary Table S1. Cytokine production by tumor cell lines derived from different organs.
Supplementary figures S1-5, materials and methods from Vimentin–ERK Signaling Uncouples Slug Gene Regulatory Function
Authors: Virtakoivu Reetta , Mai Anja , Mattila Elina , De Franceschi Nicola , Imanishi Susumu Y. , Corthals Garry , Kaukonen Riina , Saari Markku , Cheng Fang , Torvaldson Elin , Kosma Veli-Matti , Mannermaa Arto , Muharram Ghaffar , Gilles Christine , Eriksson John , Soini Ylermi , Lorens James B. , Ivaska Johanna
Published: April 2023

Supplementary figures S1-5, materials and methods. 1) Supplementary figures and associated legends: - Figure S1. ERK silencing decreases breast cancer cell migration and invasion but does not influence cell proliferation. - Figure S2. ERK2 does not interact with actin or keratin 8 and ERK2 phosphorylation is supported by vimentin but not actin. - Figure S3. Fluorescence recovery of wild-type Slug-GFP after photobleaching (FRAP). - Figure S4. Mass spectrometric identification of ERK1/2-dependent phosphorylation sites on Slug and validation using a newly generated Slug phospho-serine-87 antibody. - Figure S5. The phosphorylation status of Slug does not influence repression of E-Cadherin, Slug nuclear localisation or stability. 2) Supplementary materials and methods 3) Supplementary references
Supplementary Figures S1-S8 from A Threshold Level of Intratumor CD8+ T-cell PD1 Expression Dictates Therapeutic Response to Anti-PD1
Authors: Ngiow Shin Foong , Young Arabella , Jacquelot Nicolas , Yamazaki Takahiro , Enot David , Zitvogel Laurence , Smyth Mark J.
Published: April 2023

Supplementary Figures S1-S8. Anti-PD-1 reduces tumor weight and modulates PD-1 expressing intratumor T cells in anti-PD-1-sensitive tumor (S1); Anti-PD-1 therapy mAb does not compete for the binding of PD-1 with the anti-PD-1 flow cytometry staining mAb (S2); Anti-PD-1 mAb reduces PD-1 expression on PD-1-expressing T cells (S3); Frequency of PD-1+ CD8+ T cells maintained in anti-PD1-resistant Renca tumors (S4); Anti-Tim3 and anti-PD1 sensitivity correlates with reduced frequency of PD1 expressing CD8+ T cells (S5); Anti-PD-1/PD-L1 anti-tumor effect is FcR-independent (S6); PD-1-expressing T cells are predominantly found in the tumor microenvironment (S7); PD1 MFI on CD8+ T cells predicts tumor aggressiveness and response to anti-PD1 mAb in MC38 tumor (S8).
Supplementary Figures 1 - 7 from Twist1 Is a Key Regulator of Cancer-Associated Fibroblasts
Authors: Lee Keun-Woo , Yeo So-Young , Sung Chang Ohk , Kim Seok-Hyung
Published: April 2023

Supplementary Figure 1. Acquired CAF phenotype by conditioned media of gastric cancer cell was maintained after removal of CM. Supplementary Figure 2. Densitometric analysis of western blots. Supplementary Figure 3. The IL-6 cytokine induces the generation of Twist1 positive CAFs in vivo. Supplementary Figure 4A. Overexpression of Twist1 induced the attributes of CAFs. Supplementary Figure 4B. H&E staining of xenograft of two gastric cancer cell lines (SNU668 and SNU638) to immune compromised mice. Supplementary Figure 5. Correlation between Twist1 and CXCL12 expression in various cancers using mRNA expression data from TCGA. Supplementary Figure 6. Survival of patients with CXCL12 expression in cancer cells in gastric cancer. Supplementary Figure 7. Suppression of CXCL12 attenuates ability of tumor progression during Twist1- induced activation in gastric normal fibroblasts.
Figure S2 from Interleukin-6 Prevents the Initiation but Enhances the Progression of Lung Cancer
Authors: Qu Zhaoxia , Sun Fan , Zhou Jingjiao , Li Liwen , Shapiro Steven D. , Xiao Gutian
Published: April 2023

In vitro suppression of iNOS expression in macrophages by IL-6.
Supplementary Fig. S5 from Development of Lung Adenocarcinomas with Exclusive Dependence on Oncogene Fusions
Authors: Saito Motonobu , Shimada Yoko , Shiraishi Kouya , Sakamoto Hiromi , Tsuta Koji , Totsuka Hirohiko , Chiku Suenori , Ichikawa Hitoshi , Kato Mamoru , Watanabe Shun-ichi , Yoshida Teruhiko , Yokota Jun , Kohno Takashi
Published: April 2023

Supplementary Fig. S5. Number of non-synonimous mutations according to tumor content in pan-negative cases
Supplementary Table 1 from Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells
Authors: Lo Albert , Wang Liang-Chuan S. , Scholler John , Monslow James , Avery Diana , Newick Kheng , O'Brien Shaun , Evans Rebecca A. , Bajor David J. , Clendenin Cynthia , Durham Amy C. , Buza Elizabeth L. , Vonderheide Robert H. , June Carl H. , Albelda Steven M. , Puré Ellen
Published: April 2023

Reagents for immunohistochemistry studies.
Supplementary Figure S2 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Authors: Oshima Hiroko , Nakayama Mizuho , Han Tae-Su , Naoi Kuniko , Ju Xiaoli , Maeda Yusuke , Robine Sylvie , Tsuchiya Kiichiro , Sato Toshiro , Sato Hiroshi , Taketo Makoto Mark , Oshima Masanobu
Published: April 2023

Supplementary Figure S2. Expression levels of microenvironment factors in stroma and epithelial cells of ApcÃŽ?716 mice.
Supplemental Figure S7 from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Supplemental Figure S7. bFGF weakly blocks TGFβ2-induced SMA expression through ERK/MAPK signaling and inhibition of SMAD3 phosphorylation.
Supplementary Figure S1 from Suppressing TGFβ Signaling in Regenerating Epithelia in an Inflammatory Microenvironment Is Sufficient to Cause Invasive Intestinal Cancer
Authors: Oshima Hiroko , Nakayama Mizuho , Han Tae-Su , Naoi Kuniko , Ju Xiaoli , Maeda Yusuke , Robine Sylvie , Tsuchiya Kiichiro , Sato Toshiro , Sato Hiroshi , Taketo Makoto Mark , Oshima Masanobu
Published: April 2023

Supplementary Figure S1. Representative photographs of the whole intestine of ApcÃŽ?716 mice and ApcÃŽ?716 Tgfbr2ÃŽ?IEC mice.
Supplemental Figure S2 from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Supplemental Figure S2. Generation of the ZsGreenCdh5-Cre lineage-tracing reporter mice.
Supplemental Figure S1 from Tumor Endothelial Cells with Distinct Patterns of TGFβ-Driven Endothelial-to-Mesenchymal Transition
Authors: Xiao Lin , Kim Dae Joong , Davis Clayton L. , McCann James V. , Dunleavey James M. , Vanderlinden Alissa K. , Xu Nuo , Pattenden Samantha G. , Frye Stephen V. , Xu Xia , Onaitis Mark , Monaghan-Benson Elizabeth , Burridge Keith , Dudley Andrew C.
Published: April 2023

Supplemental Figure S1. Characterization of FN1 expression and SMAD2/SMAD3 phosphorylation in NEC versus TEC challenged with TGFβ2.
Supplemental Figure S3 from PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways
Authors: Kaistha Brajesh P. , Lorenz Holger , Schmidt Harald , Sipos Bence , Pawlak Michael , Gierke Berthold , Kreider Ramona , Lankat-Buttgereit Brigitte , Sauer Melanie , Fiedler Lisa , Krattenmacher Anja , Geisel Bettina , Kraus Johann M. , Frese Kristopher K. , Kelkenberg Sabine , Giese Nathalia A. , Kestler Hans A. , Gress Thomas M. , Buchholz Malte
Published: April 2023

Nocodazole treatment and flow cytometry.
Supplemental Figure S1 from PLAC8 Localizes to the Inner Plasma Membrane of Pancreatic Cancer Cells and Regulates Cell Growth and Disease Progression through Critical Cell-Cycle Regulatory Pathways
Authors: Kaistha Brajesh P. , Lorenz Holger , Schmidt Harald , Sipos Bence , Pawlak Michael , Gierke Berthold , Kreider Ramona , Lankat-Buttgereit Brigitte , Sauer Melanie , Fiedler Lisa , Krattenmacher Anja , Geisel Bettina , Kraus Johann M. , Frese Kristopher K. , Kelkenberg Sabine , Giese Nathalia A. , Kestler Hans A. , Gress Thomas M. , Buchholz Malte
Published: April 2023

Quantification of Plac8 signal intensities.
Supplementary Figure S2 from Long Noncoding RNA HULC Modulates Abnormal Lipid Metabolism in Hepatoma Cells through an miR-9–Mediated RXRA Signaling Pathway
Authors: Cui Ming , Xiao Zelin , Wang Yue , Zheng Minying , Song Tianqiang , Cai Xiaoli , Sun Baodi , Ye Lihong , Zhang Xiaodong
Published: April 2023

Supplementary Figure S2. HULC up-regulates the transcriptional factor PPARA to activate ACSL1, Related to Figure 2.
Supplementary Tables S2-5 from IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment
Authors: Benevides Luciana , da Fonseca Denise Morais , Donate Paula Barbim , Tiezzi Daniel Guimarães , De Carvalho Daniel D. , de Andrade Jurandyr M. , Martins Gislaine A. , Silva João S.
Published: April 2023

Supplementary Tables S2-5. Supplementary Table S2. Up-regulated gene expression microarray data in IL-17 treated 67NR cells information related Figure 6. Supplementary Table S3. Down-regulated gene expression microarray data in IL-17 treated 67NR cells information related Figure 6. Supplementary Table S4. Up-regulated gene expression microarray data in IL-17hi sample information related Figure 7. ( Supplementary Table S5. Down-regulated gene expression microarray data in IL-17lo sample information related Figure 7.
Supplementary Table S4 from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Correlation results for the novel transcripts.
Supplementary Figure 1-12 from A Novel MIF Signaling Pathway Drives the Malignant Character of Pancreatic Cancer by Targeting NR3C2
Authors: Yang Shouhui , He Peijun , Wang Jian , Schetter Aaron , Tang Wei , Funamizu Naotake , Yanaga Katsuhiko , Uwagawa Tadashi , Satoskar Abhay R. , Gaedcke Jochen , Bernhardt Markus , Ghadimi B. Michael , Gaida Matthias M. , Bergmann Frank , Werner Jens , Ried Thomas , Hanna Nader , Alexander H. Richard , Hussain S. Perwez
Published: April 2023

Figure S1. Validation of miRNA microarray data by qRT-PCR in the test cohort (n=69). Figure S2. MIF regulates miR-301b expression in human pancreatic cancer Figure S3. NR3C2 is a potential target of miR-301b. Figure S4. Endogenous NR3C2 expression was negatively correlated with MIF and miR-301b in a panel of human pancreatic cancer cell lines. Figure S5. NR3C2 enhances sensitivity to gemcitabine in pancreatic cancer cell lines. Figure S6. Knockdown of NR3C2 increases proliferation, migration and invasion, and decreases sensitivity of pancreatic cancer cells to gemcitabine. Figure S7. A lower endogenous NR3C2 expression was associated with EMT phenotype. Figure S8. NR3C2 inhibits epithelial-to-mesenchymal transition (EMT). Figure S9. MIF-induced miR-301b expression was blocked by anti-miR-301b. Figure S10. MEK inhibitor AZD6244 didn't alter miR-301b or NR3C2 in MIF-overexpressing Panc-1 and Capan-2 cells. Figure S11. NR3C2 expression is decreased in tumors as compared to adjacent nontumor tissues in PDAC. Figure S12. A lower expression of NR3C2 is associated with poor survival in multiple independent cohorts of PDAC.
Supplemental Tables S1-S7 from SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex
Authors: Feng Yongmei , Pinkerton Anthony B. , Hulea Laura , Zhang Tongwu , Davies Michael A. , Grotegut Stefan , Cheli Yann , Yin Hongwei , Lau Eric , Kim Hyungsoo , De Surya K. , Barile Elisa , Pellecchia Maurizio , Bosenberg Marcus , Li Jian-Liang , James Brian , Hassig Christian A. , Brown Kevin M. , Topisirovic Ivan , Ronai Ze'ev A.
Published: April 2023

Pharmacological properties of top four BI-69A11 analogs (S1); Blood chemistry following SBI-756 administration (S2); List of biotinylated-BI-69A11-bound proteins, identified by LC/MS/MS (S3); RPPA based analyses identify proteins that were significantly inhibited by SBI-756, compared to DMSO treatment at the 24 h time point (S4); Gene variants identified in SBI-756-resistant clones but not SBI-756-sensitive melanoma cell cultures (S5); The top 10 enriched canonical pathways identified using the Ingenuity Pathway Analysis of genes mutated in SBI-756 resistant melanoma (S6); Ingenuity Pathway Analysis of genes differentially expressed between SBI-756-sensitive and - resistant melanoma cells (S7).
Supplementary Table S2 from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Novel transcript descriptions.
Supplementary Table S1 from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Sample descriptions.
Supplemental Figure S4 from SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex
Authors: Feng Yongmei , Pinkerton Anthony B. , Hulea Laura , Zhang Tongwu , Davies Michael A. , Grotegut Stefan , Cheli Yann , Yin Hongwei , Lau Eric , Kim Hyungsoo , De Surya K. , Barile Elisa , Pellecchia Maurizio , Bosenberg Marcus , Li Jian-Liang , James Brian , Hassig Christian A. , Brown Kevin M. , Topisirovic Ivan , Ronai Ze'ev A.
Published: April 2023

SBI-756 inhibits both 3D and in vivo growth of NF1-mutant, BRAFi-resistant melanoma.
Supplementary Figures S1-S9 from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Cell cycle regulation (S1); Androgen biosynthesis and androgen receptor [AR] signaling (S2); Validation of PCAT5 expression pattern by RT-PCR (S3); Normalized read counts of four TPCATs are plotted in our BPH, PC, and CRPC samples, and complemented with prostate cancer cell lines, normal tissues, human embryonic stem cells, and prostate cancer samples from three additional data sets (S4); Inferred exon structures for four novel transcripts that were validated with RT­PCR (S5); Open chromatin markers and ERG binding at the locus of PCAT5 (S6); ETV4 and PCAT5 expression after 25nM ETV4-siRNA or scrambled CTRL-siRNA treatment in PC-3 cells (S7); Transfection with PCAT5­specific siRNAs did not affect the growth of PCAT5 negative prostate cancer cell line 22Rv1 (S8); Relative cell viability of PCAT5-siRNA transfected ERG-positive DuCaP cells (S9).
Supplemental Figure S3 from SBI-0640756 Attenuates the Growth of Clinically Unresponsive Melanomas by Disrupting the eIF4F Translation Initiation Complex
Authors: Feng Yongmei , Pinkerton Anthony B. , Hulea Laura , Zhang Tongwu , Davies Michael A. , Grotegut Stefan , Cheli Yann , Yin Hongwei , Lau Eric , Kim Hyungsoo , De Surya K. , Barile Elisa , Pellecchia Maurizio , Bosenberg Marcus , Li Jian-Liang , James Brian , Hassig Christian A. , Brown Kevin M. , Topisirovic Ivan , Ronai Ze'ev A.
Published: April 2023

SBI-756 inhibits AKT, mTOR signaling and alters cell cycle.
Supplementary Figure Legends from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Authors: Ylipää Antti , Kivinummi Kati , Kohvakka Annika , Annala Matti , Latonen Leena , Scaravilli Mauro , Kartasalo Kimmo , Leppänen Simo-Pekka , Karakurt Serdar , Seppälä Janne , Yli-Harja Olli , Tammela Teuvo L.J. , Zhang Wei , Visakorpi Tapio , Nykter Matti
Published: April 2023

Supplementary Figure Legends from Transcriptome Sequencing Reveals PCAT5 as a Novel ERG-Regulated Long Noncoding RNA in Prostate Cancer
Supplementary Figure S1 from Tumorigenic Activity of Merkel Cell Polyomavirus T Antigens Expressed in the Stratified Epithelium of Mice
Authors: Spurgeon Megan E. , Cheng Jingwei , Bronson Roderick T. , Lambert Paul F. , DeCaprio James A.
Published: April 2023

Supplementary Figure S1. Histology and MCM7 expression in the stratified epithelium of the whisker pad, footpad, and dorsal skin of ROSA26-LSL-MCPyV168 and K14Cre-MCPyV168 neonatal and adult tissues.
Supplementary Figure S6 from Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival
Authors: Langenkamp Elise , Zhang Lei , Lugano Roberta , Huang Hua , Elhassan Tamador Elsir Abu , Georganaki Maria , Bazzar Wesam , Lööf Johan , Trendelenburg George , Essand Magnus , Pontén Fredrik , Smits Anja , Dimberg Anna
Published: April 2023

Scoring of vascular CD93 expression human glioma patients and the CD93/survival correlation.
Supplementary Figure S4 from Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival
Authors: Langenkamp Elise , Zhang Lei , Lugano Roberta , Huang Hua , Elhassan Tamador Elsir Abu , Georganaki Maria , Bazzar Wesam , Lööf Johan , Trendelenburg George , Essand Magnus , Pontén Fredrik , Smits Anja , Dimberg Anna
Published: April 2023

CD93-deficiency did not affect vessel density leukocyte infiltration and pericytes proliferation and coverage in T241 fibrosarcoma and GL261 glioma.
Supplementary Figure S1 from Elevated Expression of the C-Type Lectin CD93 in the Glioblastoma Vasculature Regulates Cytoskeletal Rearrangements That Enhance Vessel Function and Reduce Host Survival
Authors: Langenkamp Elise , Zhang Lei , Lugano Roberta , Huang Hua , Elhassan Tamador Elsir Abu , Georganaki Maria , Bazzar Wesam , Lööf Johan , Trendelenburg George , Essand Magnus , Pontén Fredrik , Smits Anja , Dimberg Anna
Published: April 2023

CD93 deficiency did not inhibit s.c. B16.F10 melanoma growth in male and female mice, and T241 fibrosarcoma and GL261 glioma growth in male mice.
Supplementary Tables S1-S2 from SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
Authors: Hamblett Kevin J. , Jacob Allison P. , Gurgel Jesse L. , Tometsko Mark E. , Rock Brooke M. , Patel Sonal K. , Milburn Robert R. , Siu Sophia , Ragan Seamus P. , Rock Dan A. , Borths Christopher J. , O'Neill Jason W. , Chang Wesley S. , Weidner Margaret F. , Bio Matthew M. , Quon Kim C. , Fanslow William C.
Published: April 2023

Genes identified as critical for CD70 ADC function in Library 1 screen (S1); Genes identified as critical for CD70 ADC function in Library 2 screen (S2).
Supplementary Figures S1-S6 from SLC46A3 Is Required to Transport Catabolites of Noncleavable Antibody Maytansine Conjugates from the Lysosome to the Cytoplasm
Authors: Hamblett Kevin J. , Jacob Allison P. , Gurgel Jesse L. , Tometsko Mark E. , Rock Brooke M. , Patel Sonal K. , Milburn Robert R. , Siu Sophia , Ragan Seamus P. , Rock Dan A. , Borths Christopher J. , O'Neill Jason W. , Chang Wesley S. , Weidner Margaret F. , Bio Matthew M. , Quon Kim C. , Fanslow William C.
Published: April 2023

Predicted topology for SLC46A3 (S1); Effect of siRNA on mRNA expression of SLC46A3 and CD70 in 786-0 cells (S2); Effect of siRNA on CD70 protein expression in 786-0 cells (S3); Anti-CD70 Ab-DSG-Maytansine and anti-CD70 Ab-Cys-Maytansine are potent against CD70 expressing 786-0 Cells (S4); Lysine-MCC-DM1 concentration time course in lysosome and total cell lysate (S5); Confluency of 786-0 cells transfected with siRNA (S6).
Figure S8 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Supplementary Figure 8
Supplementary tables from TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases
Authors: Ham Boram , Wang Ni , D'Costa Zarina , Fernandez Maria Celia , Bourdeau France , Auguste Patrick , Illemann Martin , Eefsen Rikke Loevendahl , Høyer-Hansen Gunilla , Vainer Ben , Evrard Maximilien , Gao Zu-Hua , Brodt Pnina
Published: April 2023

Supplementary Table 1. List of antibodies and conditions. Supplementary Table 2. List of qPCR primers. Supplementary Table 3. Oligonucleotide sequences
Supplementary Figures from TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases
Authors: Ham Boram , Wang Ni , D'Costa Zarina , Fernandez Maria Celia , Bourdeau France , Auguste Patrick , Illemann Martin , Eefsen Rikke Loevendahl , Høyer-Hansen Gunilla , Vainer Ben , Evrard Maximilien , Gao Zu-Hua , Brodt Pnina
Published: April 2023

Supplementary Fig 1. Identification of hepatic cells that express TNFR2. Supplementary Fig 2. Loss of TNFR2 expression does not affect the induction of CAM expression on LSEC. Supplementary Fig 3. Additional characterization of MDSC isolated from wild type and TNFR2-/- mice. Supplementary Fig 4. The recruitment of Treg cells to the liver is not reduced in TNFR1-/- mice. Supplementary Fig 5. TNFR2 expression is not required for tumor or TNF-α - induced upregulation of hepatic CXCR2 chemokines. Supplementary Fig 6. Loss of TNFR2 does not affect the expression of CXCR1 and CXCR2 on MDSC. Supplementary Fig 7. Reduced TNFR2 expression in the livers of mice treated with TNFR2 ASO. Supplementary Fig 8. HLA-DR is widely expressed in the normal liver.
Figure S6 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Supplementary Figure 6
Figure S2 from Cell Cycle–Dependent Mechanisms Underlie Vincristine-Induced Death of Primary Acute Lymphoblastic Leukemia Cells
Authors: Kothari Anisha , Hittelman Walter N. , Chambers Timothy C.
Published: April 2023

Supplementary Figure 2
Suppl. Movie 2 from LIM Kinase Inhibitor Pyr1 Reduces the Growth and Metastatic Load of Breast Cancers
Authors: Prunier Chloé , Josserand Véronique , Vollaire Julien , Beerling Evelyne , Petropoulos Christos , Destaing Olivier , Montemagno Christopher , Hurbin Amandine , Prudent Renaud , de Koning Leanne , Kapur Reuben , Cohen Pascale A. , Albiges-Rizo Corinne , Coll Jean-Luc , van Rheenen Jacco , Billaud Marc , Lafanechère Laurence
Published: April 2023

MDA-MB-231 Dendra2 tumors followed by intravital microscopy after 8 days of vehicle treatment
Supplementary Figure 2 from The EGF Receptor Promotes the Malignant Potential of Glioma by Regulating Amino Acid Transport System xc(—)
Authors: Tsuchihashi Kenji , Okazaki Shogo , Ohmura Mitsuyo , Ishikawa Miyuki , Sampetrean Oltea , Onishi Nobuyuki , Wakimoto Hiroaki , Yoshikawa Momoko , Seishima Ryo , Iwasaki Yoshimi , Morikawa Takayuki , Abe Shinya , Takao Ayumi , Shimizu Misato , Masuko Takashi , Nagane Motoo , Furnari Frank B. , Akiyama Tetsu , Suematsu Makoto , Baba Eishi , Akashi Koichi , Saya Hideyuki , Nagano Osamu
Published: April 2023

Sulfasalazine does not affect intracellular ROS levels in Becker or U87MG cells.
Revised Supplementary Information from Fluorophore-NanoLuc BRET Reporters Enable Sensitive In Vivo Optical Imaging and Flow Cytometry for Monitoring Tumorigenesis
Authors: Schaub Franz X. , Reza Md. Shamim , Flaveny Colin A. , Li Weimin , Musicant Adele M. , Hoxha Sany , Guo Min , Cleveland John L. , Amelio Antonio L.
Published: April 2023

Revised Supplementary Materials and Methods and Supplementary Figure Legends
Supplementary Video S8 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: April 2023

Supplementary Video S8. Physical appearance of mice treated with MN-anti-miR10b/MN-scr-miR and doxorubicin.
Supplementary Fig. S5 from Combining miR-10b–Targeted Nanotherapy with Low-Dose Doxorubicin Elicits Durable Regressions of Metastatic Breast Cancer
Authors: Yoo Byunghee , Kavishwar Amol , Ross Alana , Wang Ping , Tabassum Doris P. , Polyak Kornelia , Barteneva Natalia , Petkova Victoria , Pantazopoulos Pamela , Tena Aseda , Moore Anna , Medarova Zdravka
Published: April 2023

Supplementary Fig. S5. Histopathological analysis of the lymph nodes and lungs of the animals obtained at the endpoint of the therapeutic study.
Supplemental Figure S2 - from The Distinctive Mutational Spectra of Polyomavirus-Negative Merkel Cell Carcinoma
Authors: Harms Paul William , Vats Pankaj , Verhaegen Monique Elise , Robinson Dan R. , Wu Yi-Mi , Dhanasekaran Saravana Mohan , Palanisamy Nallasivam , Siddiqui Javed , Cao Xuhong , Su Fengyun , Wang Rui , Xiao Hong , Kunju Lakshmi P. , Mehra Rohit , Tomlins Scott A. , Fullen Douglas Randall , Bichakjian Christopher Keram , Johnson Timothy M. , Dlugosz Andrzej Antoni , Chinnaiyan Arul M.
Published: April 2023

Supplemental Figure S2. Mutational signatures of Merkel cell polyomavirus-positive Merkel cell carcinomas
Supplemental Figure S4 from A Urokinase Receptor–Bim Signaling Axis Emerges during EGFR Inhibitor Resistance in Mutant EGFR Glioblastoma
Authors: Wykosky Jill , Hu Jingjing , Gomez German G. , Taylor Tiffany , Villa Genaro R. , Pizzo Donald , VandenBerg Scott R. , Thorne Amy Haseley , Chen Clark C. , Mischel Paul S. , Gonias Steven L. , Cavenee Webster K. , Furnari Frank B.
Published: April 2023

Supplemental Figure S4. Suppression of cell death inresistant clones
Supplementary Figure S2 from PIK3CAH1047R Accelerates and Enhances KRASG12D-Driven Lung Tumorigenesis
Authors: Green Shon , Trejo Christy L. , McMahon Martin
Published: April 2023

Ex vivo analysis of KRASG12D- versus KRASG12D/PIK3CAH1047R-driven lung tumor cell proliferation in vibratome sections.
Supplementary Figure 4 from IL6 Blockade Reprograms the Lung Tumor Microenvironment to Limit the Development and Progression of K-ras–Mutant Lung Cancer
Authors: Caetano Mauricio S. , Zhang Huiyuan , Cumpian Amber M. , Gong Lei , Unver Nese , Ostrin Edwin J. , Daliri Soudabeh , Chang Seon Hee , Ochoa Cesar E. , Hanash Samir , Behrens Carmen , Wistuba Ignacio I. , Sternberg Cinthya , Kadara Humam , Ferreira Carlos Gil , Watowich Stephanie S. , Moghaddam Seyed Javad
Published: April 2023

Supplementary Figure 4. Lung lesion distribution in lungs of CC-LR mice.
Supplemental Table and Figure Legends from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: April 2023

Supplemental Table and Figure Legends. Legends for Supplemental Table S1 and Supplemental Figures S1-S4.
Supplemental Figure S4 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: April 2023

Supplemental Figure S4. Increased Hsp47 expression has been detected in ER negative cancer and is negatively associated with GATA3 levels.
Supplemental Figure S3 from Chaperone Hsp47 Drives Malignant Growth and Invasion by Modulating an ECM Gene Network
Authors: Zhu Jieqing , Xiong Gaofeng , Fu Hanjiang , Evers B. Mark , Zhou Binhua P. , Xu Ren
Published: April 2023

Supplemental Figure S3. Hsp47 expression is associated with poor prognosis and contributes to the deposition of ECM proteins in breast cancer tissue.
Supplementary Table Legend from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
Authors: Phan Liem M. , Fuentes-Mattei Enrique , Wu Weixin , Velazquez-Torres Guermarie , Sircar Kanishka , Wood Christopher G. , Hai Tao , Jimenez Camilo , Cote Gilbert J. , Ozsari Levent , Hofmann Marie-Claude , Zheng Siyuan , Verhaak Roeland , Pagliaro Lance , Cortez Maria Angelica , Lee Mong-Hong , Yeung Sai-Ching J. , Habra Mouhammed Amir
Published: April 2023

Supplementary Table Legend from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
Supplementary Figures S1-S6 from Hepatocyte Growth Factor/cMET Pathway Activation Enhances Cancer Hallmarks in Adrenocortical Carcinoma
Authors: Phan Liem M. , Fuentes-Mattei Enrique , Wu Weixin , Velazquez-Torres Guermarie , Sircar Kanishka , Wood Christopher G. , Hai Tao , Jimenez Camilo , Cote Gilbert J. , Ozsari Levent , Hofmann Marie-Claude , Zheng Siyuan , Verhaak Roeland , Pagliaro Lance , Cortez Maria Angelica , Lee Mong-Hong , Yeung Sai-Ching J. , Habra Mouhammed Amir
Published: April 2023

High MET expression in ACC patients (S1); High MET mRNA expression levels in ACC (S2); cMET signaling is activated in ACC (S3); Increased HGF/cMET signaling is associated with enhanced proliferation and reduced apoptosis in tumors from ACC patients (S4); HGF stimulates NCI-H295R ACC cell proliferation (S5); HGF/cMET signaling is important for ACC cell energy metabolism (S6).
Table S3. Gene Set Enrichment Analysis (GSEA) C2 gene sets. from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: April 2023

Complete list of GSEA for C2 curated gene sets in the ixazomib 25nM/24 hours versus control for Jurkat, L428, and L540 cells. Leading edge analysis with a FDR {less than or equal to} 0.05 determined significant gene sets enriched for each group. The normalized enrichment score (NES) indicates whether the gene set is up- (>0) or down-regulated (<0) for each group determined with the # of leading edge genes (appears in parenthesis).
Figure S3. Inhibition of histone acetyl transferase (HAT). from Proteasomal Inhibition by Ixazomib Induces CHK1 and MYC-Dependent Cell Death in T-cell and Hodgkin Lymphoma
Authors: Ravi Dashnamoorthy , Beheshti Afshin , Abermil Nasséra , Passero Frank , Sharma Jaya , Coyle Michael , Kritharis Athena , Kandela Irawati , Hlatky Lynn , Sitkovsky Michail V. , Mazar Andrew , Gartenhaus Ronald B. , Evens Andrew M.
Published: April 2023

Inhibition of HAT with C646 resulted in decreased histone acetylation and Myc expression in L428 (HL) and Jurkat (TCL) cells on Western blot.
Supplemental Table 3 from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: April 2023

Supplemental Table 3. This Table provides all of the features initially extracted from the zebrafish images and an explanation of how each was used or not.
Supplemental Figure Legends from A Quantitative System for Studying Metastasis Using Transparent Zebrafish
Authors: Heilmann Silja , Ratnakumar Kajan , Langdon Erin M. , Kansler Emily R. , Kim Isabella S. , Campbell Nathaniel R. , Perry Elizabeth B. , McMahon Amy J. , Kaufman Charles K. , van Rooijen Ellen , Lee William , Iacobuzio-Donahue Christine A. , Hynes Richard O. , Zon Leonard I. , Xavier Joao B. , White Richard M.
Published: April 2023

These are the legends for Supplemental Figures 1-20
Supplemetary Video S2 from Snail1-Expressing Fibroblasts in the Tumor Microenvironment Display Mechanical Properties That Support Metastasis
Authors: Stanisavljevic Jelena , Loubat-Casanovas Jordina , Herrera Mercedes , Luque Tomás , Peña Raúl , Lluch Ana , Albanell Joan , Bonilla Félix , Rovira Ana , Peña Cristina , Navajas Daniel , Rojo Federico , García de Herreros Antonio , Baulida Josep
Published: April 2023

Video S2. MDA-MB231 cells on 3D-ECM generated by TGFÃŽÂ²-treated Control MEFs.
Supplementary Tables S1-S2 from Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells
Authors: Lerner Robin G. , Grossauer Stefan , Kadkhodaei Banafsheh , Meyers Ian , Sidorov Maxim , Koeck Katharina , Hashizume Rintaro , Ozawa Tomoko , Phillips Joanna J. , Berger Mitchel S. , Nicolaides Theodore , James C. David , Petritsch Claudia K.
Published: April 2023

List of antibodies used for immunostaining and flow cytometry/FACS (S1); List of primers (5'-3') used for RT-qPCR (S2).
Supplementary Figure S2 from Radiation Sensitivity in a Preclinical Mouse Model of Medulloblastoma Relies on the Function of the Intrinsic Apoptotic Pathway
Authors: Crowther Andrew J. , Ocasio Jennifer K. , Fang Fang , Meidinger Jessica , Wu Jaclyn , Deal Allison M. , Chang Sha X. , Yuan Hong , Schmid Ralf , Davis Ian , Gershon Timothy R.
Published: April 2023

Additional histologic studies.