bluuebunny/crossref_metadata_2025 huggingface dataset:
Η ζωγραφική του Δαβίδ του Σελενιτσιώτη στον ναό του Αγίου Ιωάννη του Προδρόμου στην Καστοριά (1727). Σχόλια και παρατηρήσεις
Authors: ΣΤΡΑΤΗ (Angeliki STRATI) Αγγελική
Published: November 2018

Δημοσιεύεται η ζωγραφική του ναού του Αγίου Ιωάννη του Προδρόμου στην Καστοριά, έργο του Δαβίδ του επονομαζόμενου Σελενιτσιώτη. Οι τοιχογραφίες χρονολογούνται το 1727, σύμφωνα με την κτητορική επιγραφή του ναού, και ακολουθούν το καθιερωμένο, για τους μονόχωρους μεταβυζαντινούς ναούς, εικονογραφικό πρόγραμμα. Ιδιαίτερο ενδιαφέρον έχουν οι αλληγορικές σκηνές του τροχού και του δένδρου της ζωής, των παραβολών του Χριστού και των τιμωριών των αμαρτωλών. Οι τοιχογραφίες του ναού εντάσσονται στο ρεύμα επιστροφής στην τέχνη της παλαιολόγειας εποχής, διατηρούν όμως το ιδιαίτερο προσωπικό ύφος του ζωγράφου.
Tassos Papacostas and Maria Parani (eds), Discipuli dona ferentes. Glimpses of Byzantium in Honour of Marlia Mundell Mango
Authors: ΚΑΛΟΠΙΣΗ-ΒΕΡΤΗ (Sophia KALOPISSI-VERTI) Σοφία , ΠΑΝΑΓΙΩΤΙΔΗ-ΚΕΣΙΣΟΓΛΟΥ (Maria PANAYIOTIDI-KESISOGLOU) Μαρία
Published: November 2018

Tassos Papacostas and Maria Parani (eds), Discipuli dona ferentes. Glimpses of Byzantium in Honour of Marlia Mundell Mango (Βυζάντιος. Studies in Byzantine History and Civilization 11), Brepols Publishers, Turnhout, Belgium 2017. XXX+486 σελ., 111 ασπρόμαυρες εικ., 5 ασπρόμαυροι πίν. 15,6×23,4 εκ. ISBN: 978-2-503-57585-8, E-ISBN: 978-2-503-57586-5
Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle
Authors: Modi Shalem Raju , Kokkola Tarja
Published: November 2018

GR24 is a synthetic strigolactone analog, demonstrated to regulate the development of plants and arbuscular mycorrhizal fungi. GR24 possesses anti-cancer and anti-apoptotic properties, enhances insulin sensitivity and mitochondrial biogenesis in skeletal myotubes, inhibits adipogenesis, decreases inflammation in adipocytes and macrophages and downregulates the expression of hepatic gluconeogenic enzymes. Transcription factor Nrf2 (Nuclear factor (erythroid-derived 2)-like 2) is a master regulator of antioxidant response, regulating a multitude of genes involved in cellular stress responses and anti-inflammatory pathways, thus maintaining cellular redox homeostasis. Nrf2 activation reduces the deleterious effects of mitochondrial toxins and has multiple roles in promoting mitochondrial function and dynamics. We studied the role of GR24 on gene expression in rat L6 skeletal muscle cells which were differentiated into myotubes. The myotubes were treated with GR24 and analyzed by microarray gene expression profiling. GR24 upregulated the cytoprotective transcription factor Nrf2 and its target genes, activating antioxidant defences, suggesting that GR24 may protect skeletal muscle from the toxic effects of oxidative stress.
Understanding the cultural meanings of stroke in the Ghanaian setting: A qualitative study exploring the perspectives of local community residents
Authors: Sanuade Olutobi
Published: November 2018

Background: Stroke has undergone different medical constructions over the years. While the medical profession posits that disease is a biological condition, universal and unchanging, social constructionists perceive illness as the social meaning of the biological condition. Even though the medical notion of stroke is monolithic and sometimes contradicts the representations by local community residents, little attention has been paid to understanding the cultural meanings of stroke. This study explores the cultural meanings of stroke in five different cultural settings across Ghana.

Methods: 30 focus group discussions (FGDs) were conducted with local community members in five communities (Ga Mashie, Tafo, Gyegyeano, Chanshegu and Agorve) located in five regions in Ghana. The FGDs were conducted in Ga, Twi, Fante, Ewe and Dagbani, and were transcribed verbatim into English. The transcripts were analysed thematically.

Results: The local words used for stroke in all the five cultural settings focused on physical disability associated with stroke after its onset, and this formed the dominant source of fear about the condition. Participants mentioned that spiritual and left-side stroke have the most debilitating impact on the sufferer. Although there was a general consensus that anyone can be at risk of stroke, there was a gender dynamics in the explanation of risk relativity. Participants believed that stroke can be cured through early detection and treatment, use of herbal medicines, and availability of financial resources. Compared to other disabling conditions, the community residents perceived stroke to be more severe due to the multifaceted disabilities associated with the condition.

Conclusions: This study showed that the social meanings of stroke in the five communities are multifaceted, and reflected co-existence of biomedical and cultural frameworks.  The findings showed the need to pay good attention to the sociocultural context when developing interventions strategies on stroke prevention and control in Ghana.
Clinical Annotation Reference Templates: a resource for consistent variant annotation
Authors: Yost Shawn , Münz Márton , Mahamdallie Shazia , Renwick Anthony , Ruark Elise , Rahman Nazneen
Published: November 2018

Annotating the impact of a variant on a gene is a vital component of genetic medicine and genetic research. Different gene annotations for the same genomic variant are possible, because different structures and sequences for the same gene are available. The clinical community typically use RefSeq NMs to annotate gene variation, which do not always match the reference genome. The scientific community typically use Ensembl ENSTs to annotate gene variation. These match the reference genome, but often do not match the equivalent NM. Often the transcripts used to annotate gene variation are not provided, impeding interoperability and consistency.

Here we introduce the concept of the Clinical Annotation Reference Template (CART). CARTs are analogous to the reference genome; they provide a universal standard template so reference genomic coordinates are consistently annotated at the protein level. Naturally, there are many situations where annotations using a specific transcript, or multiple transcripts are useful. The aim of the CARTs is not to impede this practice. Rather, the CART annotation serves as an anchor to ensure interoperability between different annotation systems and variant frequency accuracy. Annotations using other explicitly-named transcripts should also be provided, wherever useful.

We have integrated transcript data to generate CARTs for over 18,000 genes, for both GRCh37 and GRCh38, based on the associated NM and ENST identified through the CART selection process. Each CART has a unique ID and can be used individually or as a stable set of templates; CART37A for GRCh37 and CART38A for GRCh38.

We have made the CARTs available on the UCSC browser and in different file formats on the Open Science Framework: https://osf.io/tcvbq/. We have also made the CARTtools software we used to generate the CARTs available on GitHub.

We hope the CARTs will be useful in helping to drive transparent, stable, consistent, interoperable variant annotation.
СТРАТЕГИЧЕСКАЯ ЛИНИЯ ПОВЫШЕНИЯ КВАЛИФИКАЦИИ УЧИТЕЛЕЙ НАЧАЛЬНЫХ КЛАССОВ В СОВРЕМЕННЫХ УСЛОВИЯХ
Authors: Mitina Galina Valentinovna
Published: November 2018

Цель исследования заключалась в определении ключевых ориентиров повышения квалификации учителей начальных классов в современных условиях. Кроме того, наша задача состояла в том, чтобы соотнести процесс обучения педагогов-практиков с актуальной нормативно-правовой базой в сфере образования.Предыдущие исследования показали, что в последние годы повышение квалификации педагогов начальной школы связывается либо со спецификой их профессиональной деятельности, либо с организацией процесса воспитания обучающихся. Вместе с тем, в принятых в последние годы нормативных правовых актах и нормативных документах (Федеральный закон № 273-ФЗ «Об образовании в Российской Федерации», Профессиональный стандарт «Педагог», Федеральный государственный образовательный стандарт начального общего образования) четко определяются основные положения относительно компонентов организации данного процесса.Методы исследования. Данные для этого исследования были собраны на основе сравнительно-сопоставительного и ретроспективного анализа трудов педагогов и психологов; изучения нормативно-правовой документации в сфере образования; моделирования процесса повышения квалификации педагогов начальной школы.Результаты работы. Проведенное исследование показало, что ключевым ориентиром профессиональной деятельности учителей начальных классов в современных условиях является реализация системно-деятельностного подхода, обеспечивающего социокультурное развитие (социализацию) младших школьников. Это определило цели и направленность указанного процесса. Содержание и организационные формы повышения квалификации педагогов начальной школы определены на основе идеи непрерывного образования А.А. Вербицкого. Считаем возможным при планировании курсов повышения квалификации учителей начальных классов в современных условиях ориентироваться на три содержательных модуля: информационно-мотивирующий, содержательно-ориентационный, конструктивно-преобразующий. Содержание каждого модуля, как функционального узла системы повышения квалификации учителей начальных классов, включает компоненты, обозначенные в Законе «Об образовании»: цели, направленность, формы, образовательные технологии, содержание повышения квалификации.Область применения результатов. Предложенная модель может быть использована при разработке содержания программ дополнительного профессионального образования.
Concepts of modern natural science
Authors: Островский Эдуард , Ostrovskiy Eduard
Published: November 2018

In the light of the latest achievements of natural science in the textbook considered the modern scientific picture of the world. The process of development of the basic natural-scientific ideas and methodology of their formation is shown. The manual includes a set of didactic materials designed to promote deeper assimilation of the content of the discipline by students.
Corresponds to the current Federal state educational standard of higher education of the last generation.
For students of universities of economic and humanitarian areas.
CARACTERÍSTICAS DISCURSIVAS EM LÍNGUA ESPANHOLA, UMA CONTRIBUIÇÃO À LINGUÍSTICA DE CORPUS.
Authors: Dias Barbara Soares da Silva
Published: November 2018

Resumo: O suporte tecnológico por voz em língua estrangeira aos clientes passa a ser uma necessidade das empresas nacionais na medida em que a economia brasileira se internacionaliza. Embasado em pesquisa realizada para o desenvolvimento do Mestrado em Linguística Aplicada junto à Pontifícia Universidade Católica de São Paulo[1], o presente artigo analisa o Service Desk - prestação de serviço de TI dentro dos serviços de gerenciamento de Tecnologia da informação (ITSM) conforme definido pela metodologia ITIL (Biblioteca de Infraestrutura de Tecnologia da Informação) de uma empresa prestadora de serviços. O método da pesquisa consiste nos seguintes passos: um conjunto de ligações foi colhido, criando um corpus de 70 textos tendo sido  completamente etiquetado com o etiquetador Biber Spanish Tagger. Segundo, os dados foram submetidos ao software estatístico SPSS, e uma anotação manual dos níveis de performance de qualidade e suas características linguísticas foi executada por meio de taxonomia desenvolvida para essa pesquisa, baseada em Michael Hoey (1983). Justifica-se a relevância do estudo como contribuição à Linguística de Corpus.  Os resultados indicaram baixa recorrência de dificuldade de linguagem nas ligações para o que era esperado; embora esta baixa recorrência tenha causado impacto no departamento e, justifica que tais resultados possam ser trabalhados em uma rotina de treinamento.[1] DIAS, B.S.S. Relação de qualidade no atendimento e características linguísticas do discurso da microinformática (Service Desk) em língua espanhola: um estudo em Linguística de Corpus (Dissertação). Mestrado em Linguística Aplicada. Pontifícia Universidade Católica de São Paulo, 2013.
AQUISIÇÃO DO LÉXICO NA APRENDIZAGEM DO PORTUGUÊS L2: O CASO DE ANGOLA
Authors: Marçalo Maria João , Nauege João Muteteca
Published: November 2018

A reflexão sobre aquisição do léxico na aprendizagem do PL2 no contexto angolano aborda a necessidade de se repensar o ensino-aprendizagem do léxico por meio da sua faceta activa o vocabulário, podendo ser feito de uma forma explícita para que as aprendizagens sejam mais sólidas. Fazendo um nexo com a realidade angolana, acresce outra discussão que tem que ver com metodologias explícitas para se ensinar o léxico e o vocabulário, com base em metodologia de PL2.
Discrete event simulation of multimodal and unimodal transportation in the wood supply chain: a literature review
Authors: Kogler Christoph , Rauch Peter
Published: November 2018

This review systematically analyses and classifies research and review papers focusing on discrete event simulation applied to wood transport, and therefore illustrates the development of the research area from 1997 until 2017. Discrete event simulation allows complex supply chain models to be mapped in a straightforward manner to study supply chain dynamics, test alternative strategies, communicate findings and facilitate understanding of various stakeholders. The presented analyses confirm that discrete event simulation is well-suited for analyzing interconnected wood supply chain transportation issues on an operational and tactical level. Transport is the connective link between interrelated system components of the forest products industry. Therefore, a survey on transport logistics allows to analyze the significance of entire supply chain management considerations to improve the overall performance and not only one part in isolation. Thus far, research focuses mainly on biomass, unimodal truck transport and terminal operations. Common shortcomings identified include rough explanations of simulation models and sparse details provided about the verification and validation processes. Research gaps exist concerning simulations of entire, resilient and multimodal wood supply chains as well as supply and demand risks. Further studies should expand upon the few initial attempts to combine various simulation methods with optimization.
MINIMAL NON-INTEGER ALPHABETS ALLOWING PARALLEL ADDITION
Authors: Legerský Jan
Published: November 2018

Parallel addition, i.e., addition with limited carry propagation has been so far studied for complex bases and integer alphabets. We focus on alphabets consisting of integer combinations of powers of the base. We give necessary conditions on the alphabet allowing parallel addition. Under certain assumptions, we prove the same lower bound on the size of the generalized alphabet that is known for alphabets consisting of consecutive integers. We also extend the characterization of bases allowing parallel addition to numeration systems with non-integer alphabets.
EFFECT OF IMPERATA CYLINDRICA REINFORCEMENT FORM ON THE TENSILE AND IMPACT PROPERTIES OF ITS COMPOSITES WITH RECYCLED LOW DENSITY POLYETHYLENE
Authors: Olusunmade Olusola Femi , Bulus Abba Emmanuel , Kashin Terwase Kelvin
Published: November 2018

Composites of recycled low-density polyethylene obtained from waste water-sachets and imperata cylindrica were produced with particulate and long-fibre unidirectional mat reinforcements. Comparison was made of the tensile and impact properties resulting from the use of the different reinforcement forms at 10 wt% ratio in the matrix. The results obtained from the tests carried out revealed that tensile strength, tensile modulus, elongation at break and impact strength of the composite with the long-fibre mat reinforcement were better than those of the one composite with the particulate reinforcement. The better performance observed in the long-fibre mat reinforcement could be attributed to the retention of the toughness and stiffness of the imperata cylindrica stem in this form of reinforcement, which is lost after the stem strands are pulverized into particles. Imperata cylindrica stem, as a natural fibre reinforcement for polymetric material is, therefore, recommended in the long-fibre mat form. The combination of these otherwise challenging resources in composite materials development will add economic value to them and help to reduce the nvironmental menace they present.
Libertad a medias
Authors: González Galindo Gabriel Giovanni
Published: November 2018

El avance tecnológico ha demandado la creación de entes lógicos para controlar los dispositivos electrónicos llamados software; sin embargo, la industria tecnológica ha generado riquezas exageradas a costa de usuarios que no conocen sus verdaderos requerimientos y, por ende, no pueden elegir con libertad lo que necesitan para poder realizar las tareas de su vida cotidiana, recayendo en gastos e “inversiones” innecesarias, pero que benefician a ciertos sectores. Así pues, este trabajo pretende dar una visión más global de lo que se denomina software y conocer sus diferentes formas, para así poder realizar y tomar decisiones con libertad, pues es necesario tener conciencia del rol del usuario y cómo puede ayudar a mejorar su situación actual como individuo frente a la constante relación con los otros sujetos
Proyectos pedagógicos productivos como proyecto de vida de egresados de la IETAD
Authors: Villamil Alberto Fonseca
Published: November 2018

El objetivo de este artículo es describir los resultados de la investigación que con enfoque mixto se realizó para visibilizar criterios de sostenibilidad y desarrollo económico de los Proyectos Pedagógicos Productivos PPP formulados por egresados de la Institución Educativa Técnica Agropecuaria de Desarrollo Rural del municipio de Pauna Boyacá, Colombia. Presenta una reflexión en torno a los factores de tipo sociocultural y económico del contexto que puedan incidir en la no ejecución de los mismos y, consecuentemente, en el escaso aporte al desarrollo de sus proyectos de vida. Búsqueda que finalmente indica, primero, la incoherencia entre la política educativa que reglamenta la educación rural y la realidad del contexto en el cual esta se inserta; y, segundo, no se les otorga a dichos proyectos la importancia que ameritan en cuanto a la formación de competencias para el trabajo y el aprovechamiento de los recursos propios de la región.
The Virgin with the Sleeping Child Jesus: study of two overlapping images
Authors: Calvo Ana , Chércoles Ruth , Sánchez Alicia , San Andrés Margarita
Published: November 2018

This paper presents the study of an anonymous painting on canvas with the representation of The Virgin with the Sleeping Child Jesus. During the restoration process, an underlying paint was detected and the radiograph showed the existence of an underlying composition. The theme is the same, apparently in the finished pictorial phase, but flipped horizontally with respect to the visible picture, as if it were its specular image. This infrequent circumstance aroused a study of materials with the aim of trying to trace the avatars of the work over time. The results of the stratigraphic analysis by microscopic techniques (OM and SEM-EDX) show the use of very similar pigments. The use of colored ground in the original paintings and especially the use of smalt in all cases, together with the analysis of the style of both representations as well as the models used, lead us to situate the execution of both works, the visible and the underlying, in the end of 17th or beginning of 18th century.
A “concept” and a “literary concept” in a conceptological approach
Authors: Makarowska Olga
Published: November 2018

This article is an attempt to organize the terminological apparatus of conceptology due to a large number of terms containing the word ‘concept’. The article presents a discussion of the differences and similarities between the terms concept and literary concept as well as the model structure of a literary concept.
Zintegrowane podejście w nauczaniu języka obcego
Authors: Paliński Antoni
Published: November 2018

This article deals with two of the four primary language skills – listening and reading. The author tries to show not only differences but also similarities between these two receptive language skills, as research has shown that they are very close to one another and have much in common, especially in terms of psychological aspects. The author draws readers’ attention to the fact that both processes – listening and reading – are connected with acquiring and understanding information, entail a critical and creative interpretation of a given text, have similar structure as well as require much concentration and ability to read between the lines, and, furthermore, to understand what is not said or written directly. It is suggested that an integrated approach should be incorporated into the foreign language teaching process, as there are clear similarities between the two aforementioned language skills, especially in the psychological dimension.
Чемпионат Европы по футболу 2012 глазами польских и русских интернетчиков
Authors: Kuligowska Katarzyna
Published: November 2018

The author presents the response of Internet users to the incidents thatoccurred during Euro 2012. A sociolinguistic analysis of comments on the fights between Polish and Russian fans was carried out. Several aspects of the national stereotypes included in the analyzed internet opinions that had been published on the Internet were presented.
Экспрессивная функция префиксальной морфемы в романе А.С. Пушкина
Authors: Горбунова Светлана
Published: November 2018

The article is devoted to studying word-building as a means of achievingexpression in Pushkin’s Eugene Onegin; particular attention is given to the prefixal morpheme. As for the fact that the novel was written in verse, the author analyzes the processes associated with implementing the poetic function of language
Culpa in Contrahendo, Promissory Estoppel, Pre-Contractual Good Faith and Irredeemable Acts
Authors: Kovac Mitja
Published: November 2018

Concepts of pre-contractual good faith, culpa in contrahendo and promissory estoppel have received increasing attention from legal scholars, law makers and practitioners. Those concepts appear as fundamental in all civil and common law systems and yet as ones whose nature and contents are still ill-defined. Moreover, recent doctrinal developments in Chinese and in the modernized French Law of contracts call for further systematic assessment. This paper fills the gap by providing an evaluation of the English, French, German and Chinese law of contracts. It offers a comparative law and economics evaluation and argues that those duties serve as a multi-functional judicial mechanism enabling ex post screening between socially desirable and undesirable behavior. They set the behavioral standards and serve as deterrence mechanisms that attempt to discourage certain socially undesirable behaviour in the course of the negotiations. The paper seeks to find out what new light the comparative law and economic analysis can shed on the issues of pre-contractual good faith, culpa in contrahendo and promissory estoppel to help to clarify it.
On the origin and formation of the early Qin Culture
Authors: Liang Yun
Published: November 2018

The early Qin Culture refers to the Qin Culture from the Western Zhou Dynasty to the early Spring-and-Autumn Period. Considering its cultural composition, we will realize that it has three main sources, namely the Shang, Zhou, and Western Rong (Western Barbarian) Cultures. The elements derived from the Shang Culture comprised the furniture of waist pits and the custom of dog burial in graves, the use of human sacrifice, the interment of chariots and horses, the Shang-style pottery wares and the tradition of constructing huge-scale mausoleums. These elements reflect that the Qin people initially came from the east and had strong ties with the Shang Dynasty and were deeply influenced by the Shang Culture, and belonged to the Yin people (after the fall of the Shang Dynasty) in the broader sense. The elements absorbed from the Zhou Culture comprised the architectural types of ancestral temples and palaces, the adoption of the ritual vessels, the suspended musical instruments, the Zhou style pottery wares and the writing system. These elements indicate that the Qin people adopted the ritual and musical culture of the Western Zhou Dynasty, which had a great political significance at the early stage of Qin’s history. The factors derived from the cultures of the Western Rong ethnic group or the northern steppes included the flexed burial position, the golden body ornaments and chariots and horses, iron wares, animal motifs on utensils, recesses on the walls of the burial pits and the ditches around the graves, the use of bronze cauldrons and swords (daggers). Such elements reflect that during the development process in the Longyou region, the Qin people absorbed the cultures of the adjacent Western Rong ethnic group, the Eurasian steppes and farther beyond. The first kind of elements continued to predominate the Qin Culture down to the middle Western Zhou, then the second and the third ones arose from the late Western Zhou to the early Spring-and-Autumn Period, and simultaneously, the first were only present in the aristocratic burial activities. Based on the remnants of the Shang Culture, the early Qin Culture came into being by widely absorbing elements of the Zhou and Western Rong Cultures.
The development and formation of soldering technique on the bronze ritual vessel casting of the Shang and Zhou Dynasties
Authors: Zhang Changping
Published: November 2018

This paper concerns the development of soldering in early China. Soldering requires the use of an additional heating of metal to join two or more existing metal items together. The paper defines the different soft and hard soldering materials. It also describes the evolution from joining two pieces, an animal head and a vessel with additional pour of bronze as an extension of the casting process. The next step was the use of hard solder, using bronze or copper related materials. There were two ways to join the existing bronze sections: the most common was “tenon soldering”. Less common but equally significant was “injection soldering”. In the late Spring-and-Autumn Period, soft soldering with tin and lead was developed. This step allowed much more extravagant decoration of bronzes, leading to new bronze vessel styles and also to much greater sub-division of labor in the production process.
Effects of different exercise loads on the thyroid hormone levels and serum lipid profile in swimmers
Authors: Kocahan Sayad , Dundar Aykut
Published: November 2018

Background

The aim of this study was to investigate the effects of different exercise loads (short, medium and long swimming distances) on the thyroid hormone (THs) levels and serum lipid profiles of male professional swimmers.

Materials and methods

The participants in this study were 20 healthy male professional swimmers aged 18–22 years, who all competed at an elite level. The THs levels [thyroid-stimulating hormone (TSH), triiodothyronine (T3) and thyroxine (T4)] and serum lipid profile were also obtained.

Results

It was determined that the TSH and T4 values increased after exercise (p < 0.05). When compared to the pretest values, the increase in the TSH and T4 values following the L400 tests was statistically significant (p < 0.001 and p < 0.05). It was also determined that the changes in the cholesterol, high-density lipoprotein (HDL) and total glucose (TG) values were significant after exercise (p < 0.001). There was no significant difference between the groups in terms of the low-density lipoprotein (LDL) values (p = 0.07). According to the results, the cholesterol counts for the M200 and L400 groups were lower than the pretest counts (p < 0.001). When compared to the pretest values, the decrease in the HDL counts for the M200 and L400 groups was higher than the pretest HDL counts (p < 0.001 and p < 0.05, respectively). Further, the triglycerides counts for the M200 and L400 groups were higher than the pretest counts (p < 0.001).

Conclusions

Different exercise loads can have a positive impact on the physical health of swimmers via their lipid profiles and THs. Additionally, swimming exercise could be considered an efficient protective strategy against metabolic disorders, as it serves to balance the serum lipid levels.
Direct and indirect effects of psychopharmacological treatment on the cardiovascular system
Authors: Kahl Kai G.
Published: November 2018

Background

Severe mental disorders, i.e. psychotic disorders, unipolar and bipolar disorders are associated with increased morbidity and mortality from cardiovascular and metabolic disorders. The underlying cause of this association is complex and comprises disorder specific alterations such as dysfunctions of immunological and hormonal systems, body-composition changes and health associated behaviors (smoking, sedentary lifestyle, alcohol intake and treatment compliance). Furthermore, some psychopharmacological drugs may exert unwanted side effects that impact the cardiovascular system.

Methods

This paper reviews studies concerning commonly used antidepressant and antipsychotics drugs with a particular focus on direct and indirect cardiovascular side effects.

Results

Newer antidepressant drugs have a favorable cardiovascular safety profile compared to tricyclic antidepressants. However, QTc prolongation, increased blood pressure and potentially higher risks of bleeding have been observed in some newer antidepressants. Some second generation (atypical) antipsychotics have raised concern because of indirect cardiovascular, metabolic side effects such as weight gain and disturbances in lipid and glucose metabolism.

Conclusions

Psychiatrists need to be aware of potential direct and indirect cardiovascular side effects and to include them in the risk/benefit assessment when choosing a specific individualized treatment.
Begreifbare Learning Environments
Authors: Robben Bernard , Herzig Bardo , Klar Tilman-Mathies , Schelhowe Heidi
Published: November 2018

We propose a framework of Interaction Design for Reflective Experience (RED). “Begreifbare” (graspable, in the sense of tangible and comprehensible) learning environments embody a designed experience that combines abstraction and concreteness, perception and cognition, and thus emphasizes both the impact of tangible, embodied interactions and the importance of symbols and signs for reflective experience. Our framework is based on the categories of space and experience, model and reflection.
Embedded Computation versus Embodied Interaction: Connected Objects for Connected Thinking
Authors: Hemmert Fabian , Bradford Elizabeth , Caetano Erik , Kegel Friedrich , Licht Eva , Höwer Marco
Published: November 2018

What will future creativity-based work in collaboration with ubiquitous, AI-driven systems be like? In this paper, we argue that following a ‘tangible interaction’ approach can be beneficial in this context. We describe six connected objects that illustrate how the quality of future creative work could be designed. The objects aim to shape embedded computation in ways that support embodied interaction. They include a place for sacrificing one’s phone, an olfactory calendar, a reader/writer for cloud data in everyday objects, a concrete-based data logger, a slot machine for recombining old ideas into new ones, and a dimmer for artificial intelligence. We summarize the results of a critical reflection of the prototypes in an argument for designing interactions that foster collaborative creative processes between embodied humans in a world of embedded computation.
Designing Metaphor-Based Ambient Tangible Artifacts to Support Workspace Awareness
Authors: Matviienko Andrii , El Ali Abdallah , Hilmer Christin , Feld Yannick , Heuten Wilko , Boll Susanne
Published: November 2018

Current asynchronous (e. g., email) or synchronous (e. g., video-conferencing) communication methods in the workspace can be obtrusive and fail to mimic spontaneous interpersonal communication. This can cause difficulties in forming close relationships among working colleagues. To examine this problem, we conducted a needs assessment study consisting of an online survey, a focus group, and a co-design session to gather a set of system requirements and metaphors as a base for future system designs. Based on the results, we designed two metaphor-based ambient tangible systems to support awareness among working colleagues:AwareCupsandAwareHouse. Furthermore, we evaluated these systems in a short field study with 22 participants and found that both systems are highly intuitive and easy to use. We discuss the solution space for metaphor-based tangible awareness systems and the effects of the outcomes on the potential increase of awareness among colleagues.
Add-Aptation: Simon Stephens, Carrie Cracknell and Katie Mitchell’s ‘Dialogues’ with the Classic Canon
Authors: Bull John
Published: November 2018

AbstractAddition and Add-Aptation

This article discusses, in particular, the playwright Simon Stephens’s “English Language versions” of Ibsen’s A Doll’s House and Chekhov’s The Cherry Orchard in the context of the long and tangled history of translation and adaptation. Key differences from the conventional claim to be attempting some kind of fidelity to the original in Stephens’s approach to the task of creating a new text are considered: an approach which largely adheres to the overall narrative structure of the original but feels free to play with, in particular, the dialogue. This approach is then contrasted with the act of ‘appropriation’ of an existing text: whilst the act of appropriation results in the creation of an independent play that exists alongside the original, although Stephens actively disrupts expectations of fidelity, his version is still offered as a play by Ibsen or Chekhov. The process is further problematized by the directorial interventions of Carrie Cracknell and Katie Mitchell, working independently and in collaboration with Stephens on their productions of A Doll’s House and The Cherry Orchard respectively. I have labelled this process Add-Aptation, to distinguish it from both adaptation per se and appropriation. In an add-apted text the additions are both deliberate and significant Not the least significant factor in this process is that both directors are women, as is increasingly likely to be the case in the world of contemporary theatre.
Diagnostic performance of microRNAs in the circulation in differential diagnosis of BPH, chronic prostatitis and prostate cancer
Authors: Dülgeroğlu Yakup , Eroğlu Onur
Published: November 2018

Background

In this study, the objective was to evaluate the diagnostic performance of some miRNAs, which were shown to have a diagnostic value for prostate cancer (PCa), and the effect of chronic prostatitis in distinguishing benign prostatic hyperplasia (BPH) and PCa.

Materials and methods

Serum levels of 11 miRNAs were investigated in BPH, chronic prostatitis and PCa patients. Measurements were performed using qRT-PCR.

Results

In the analysis, serum levels of miR-375, -125b-5p, -30c-5p, -26b-5p, and let-7c-5p were downregulated in cancer compared with non-cancer group and AUCs of these miRNAs in distinguishing PCa group from non-cancer group were calculated as 0.781, 0.782, 0.762, 0.874, and 0.845, respectively. AUC of the combination of miR-375 and miR-26b-5p in distinguishing PCa group from non-cancer group was 0.891, AUC of these two miRNAs in distinguishing PCa group from BPH group was 0.944.

Conclusion

In our study, 11 miRNAs were studied and 5 of these miRNAs were considered as biomarker candidates as these miRNAs, individually or combined, could be used to distinguish PCa from benign conditions. Furthermore, a higher specificity and sensitivity were obtained in distinguishing BPH and PCa when data for diagnostic potential of miRNAs were analyzed without including chronic prostatic group.
Viscometric and Conductometric Studies of Solvation Behaviour of Tetraalkylammonium Salts in the Binary Mixtures of Dimethylsulfoxide and Methanol at 298.15 K
Authors: Anand Hardeep , Verma Renu
Published: November 2018

Molar conductance and viscosity of some tetraalkylammonium perchlorates (R4NClO4 where R = Methyl, Ethyl, Propyl, Butyl) have been measured in the concentration range (30–500) × 10−4 mol kg−1 at 298.15 K in the binary mixtures of dimethylsulfoxide (DMSO) + methanol (MeOH) containing 0, 20, 40, 50, 60, 80 and 100 mol% methanol. Conductance data has been analyzed using the Shedlovsky equation and the viscosity data by Jones-Dole equation. The limiting ionic conductances (

λ
±
o

$\lambda_{\pm}^{o}$

) were used to calculate the solvated radii (ri
) of the ions. The A and B coefficients of the Jones-Dole equation are positive in all salts. The A coefficients are in reasonable good agreement with the limiting theoretical values (Aη
) calculated using Falkenhagen-Vernon equation. The variation of the ionic B±
coefficients as well as the actual solvated radii (ri
) with solvent composition in DMSO + MeOH mixtures show the preferential solvation of tetraalkylammonium ions by MeOH and MeOH-rich region of the mixtures. The tetraalkylammonium ions exhibit solvation in the order Me4N+ > Et4N+ > Pr4N+ > Bu4N+.
Defect Detection and Monitoring in Metal Additive Manufactured Parts through Deep Learning of Spatially Resolved Acoustic Spectroscopy Signals
Authors: Williams Jacob , Dryburgh Paul , Clare Adam , Rao Prahalada , Samal Ashok
Published: November 2018

Laser powder bed fusion (LPBF) is an additive manufacturing (AM) process that promises to herald a new age in manufacturing by removing many of the design and material-related constraints of traditional subtractive and formative manufacturing processes. However, the level and severity of defects observed in parts produced by the current class of LPBF systems will not be tolerated in safety-critical applications. Hence, there is a need to introduce information-rich process monitoring to assess part integrity simultaneously with fabrication so that opportune corrective action can be taken to minimize part defects. Spatially Resolved Acoustic Spectroscopy (SRAS) is a uniquely positioned nondestructive acoustic microscopy sensing approach that has been successfully used to probe the mechanical properties and assess the presence of defects in LPBF parts. However, the technique is sensitive to extraneous phenomena, such as surface reflectivity, which occur within the LPBF system and may occlude identification of surface breaking and subsurface defects. With a view to applying the SRAS technique for in-process monitoring in a production-scale LPBF environment and to overcome the foregoing challenge, this study proposes the use of a deep learning convolutional neural network that is termed Densely connected Convolutional Block Architecture for Multimodal Image Regression (DCB-MIR), which invokes SRAS-derived acoustic velocity maps of the part as input data and translates them to an output resembling an optical micrograph. Through this approach, we demonstrate that defects, such as porosity and surface imperfections in titanium alloy and nickel alloy specimens made using LPBF, which were not clearly discernable in the as-measured SRAS acoustic map and were obscured by artifacts in the optical image, are accurately identified. To quantify the accuracy of the approach, the cosine similarity between the predicted output images and target optical images was used as the objective function of DCB-MIR. The cosine similarity between the acquired SRAS signatures and the corresponding as-measured optical micrographs of samples typically ranged between –0.15 and 0.15. In contrast, when the optical micrograph-like images derived from DCB-MIR proposed in this work were compared with the optical signatures, the cosine similarity improved in the range of 0.25 to 0.60.
PEDAGOGICAL CONTENT KNOWLEDGE DEPELOPMENT OF SCIENCE PROSPECTIVE TEACHERS IN PROFESSIONAL PRACTICE PROGRAM
Authors: Rochintaniawati Diana , Widodo Ari , Riandi Riandi , Herlina Lina
Published: November 2018

The study of “Pedagogical Content Knowledge Development of Science Prospective Teachers in Professional Practice Program” was conducted in one junior high school located in Bandung. The purpose of the study was to analyze the level and pattern of science prospective teachers’ PCK development as measured by CoRe. The study involved students who enrolled professionals practice program. Mixed methods, quantitative and qualitative research was utilized as a method in the study. Data collected by the coding and scoring of the CoRe instruments were analyzed  quantitatively; and data gained from observation, documentation, and interviews were analyzed qualitatively. The results showed that the PCK of prospective teachers are in the maturing PCK (level 3) and growing PCK (level 2). There are two patterns of PCK development showed by prospective teachers i.e. rising and fluctuative. The prospective teachers who are in the mature PCK show the pattern of rising, whereas prospective teachers who are in the growing PCK show fluctuative pattern. The study reveals that external and internal factors influenced the development of PCK. The pattern of guidance, lesson study activities, and intensity guidance are external factors that influenced the pattern of prospective students’ PCK development. Psychological effect that exists between teachers and students, the motivation of self to expand the horizons of knowledge, communication skills, and teaching experiences are the internal factors that influenced the development of prospective teacher PCK. The study suggests that the development of prospective teachers PCK in the program can be improved when supervisor and prospective teachers put consideration to those internal and external factors that influence the development of PCK.
Peroxisome proliferator-activated receptor gamma and BRCA1
Authors: Furth Priscilla A
Published: November 2018

Peroxisome proliferator-activated receptor gamma agonists have been proposed as breast cancer preventives. Individuals who carry a mutated copy of BRCA1, DNA repair-associated gene, are at increased risk for development of breast cancer. Published data in the field suggest there could be interactions between peroxisome proliferator-activated receptor gamma and BRCA1 that could influence the activity of peroxisome proliferator-activated receptor gamma agonists for prevention. This review explores these possible interactions between peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma agonists and BRCA1 and discusses feasible experimental directions to provide more definitive information on the potential connections.
Creando contextos de comprensión: Rol estudiantil en las instancias de lectura en la sala de clases
Authors: Bustos-Ibarra Andrea Verónica , Montenegro-Villalobos Cintia Susana , Sandoval-Santana Wilma Lorena , Melo-Letelier Giselle Francis
Published: November 2018

Se caracterizaron los tipos de episodios y las estructuras de participación de 9 docentes de Chile de 3º, 5º y 7º de primaria en clases de Ciencias, Historia y Lenguaje en instancias de lectura colectiva. Se utilizó el sistema de análisis propuesto por Sánchez et al (2008), en el cual se analizó la frecuencia de aparición de los episodios de planificación e interpretación/evaluación y la estructura de participación presente en ellos. Los resultados muestran un bajo porcentaje de episodios de planificación con un alto dominio del discurso docente. Asimismo, una mayor frecuencia en episodios de interpretación/evaluación con escasa participación de estudiantes, indistintamente de la asignatura o nivel escolar. Los resultados permiten dilucidar el contexto en que se generan las lecturas colectivas y cómo ello condiciona el rol del sujeto aprendiz como persona lectora en formación.
Percepción del estudiantado activo sobre las causas del abandono escolar en instituciones de secundaria de la Dirección Regional de Enseñanza de Cartago, Costa Rica
Authors: Ramírez Diaz Jose Laurian , Castro Acevedo Dinorah , Arrieta Quesada Marcela , Redondo Hernández Mayra , Brenes Zamora Manuel Alfonso
Published: November 2018

Son varios los estudios que se han hecho sobre abandono escolar, debido a sus repercusiones tanto para la persona como para la sociedad. En el ámbito costarricense se han creado programas de ayuda socioeconómica, pedagógica y psicosocial, que buscan mantener al estudiantado en las aulas, pero el fenómeno ha prevalecido en el tiempo. También se han implementado estrategias aisladas que pretenden disminuir los índices de exclusión escolar; pero su impacto no ha sido evaluado apropiadamente y tampoco se han socializado los resultados. Este documento presenta un estudio cuantitativo factorial comparativo que se realizó con 624 estudiantes de 20 colegios entre técnico profesionales y académicos de la Dirección Regional de Enseñanza de Cartago, tanto de modalidad diurna como nocturna, quienes expusieron su percepción sobre las causas del abandono escolar. Se busca proponer criterios técnicos de diagnóstico que sirvan como puntos de partida para implementar estrategias y acciones preventivas del abandono escolar, y que sean útiles como referencia para profesionistas en educación que se preocupan por esta problemática y desean ejecutar acciones de intervención y de prevención, en las cuales se consideren la motivación y el sentido de pertenencia del estudiantado al contexto educativo, como pilares de acciones preventivas y de gestión educativa.
El reto de la identidad para la educación como institución social
Authors: Matías González Alberto , Hernández del Cristo Shirley Bárbara
Published: November 2018

La realización y construcción social de la identidad humana es una permanente convocatoria para repensar su ejercicio y significado. El presente ensayo participa de este empeño y su objetivo es lograr una aproximación teórica al sentido e influencia de la construcción del valor identidad para la educación en condiciones de lucha por la igualdad social. El aporte radica en una visión fundamentada en torno al lugar de la educación en el despliegue de relación identidad/diferencia y asume que la búsqueda de la igualdad social es fundamental para ello. Las nociones reflexivas fueron elaboradas desde las realidades de los países en desarrollo, realidades que están insertadas en un siglo en que el mundo se revoluciona en el campo de las tecnologías y donde, por otra parte, florecen las intolerancias y fundamentalismos sociales. La conclusión fundamental a que se llega es que la búsqueda de la igualdad en la diferencia debe ser prioridad para la construcción social de la identidad y, en ello, juega un papel central la educación.