bluuebunny/crossref_metadata_2025 huggingface dataset:
The Effect of Dental Treatment under General Anesthesia on Quality of Life and Growth and Blood Chemistry Parameters in Uncooperative Pediatric Patients with Compromised Oral Health: A Pilot Study
Authors: Ferrazzano Gianmaria F. , Salerno Claudia , Sangianantoni Giancarla , Caruso Silvia , Ingenito Aniello , Cantile Tiziana
Published: June 2020

Background: The effect of untreated dental caries and their treatment under general anesthesia (GA) on the quality of life, growth, and blood chemistry parameters in uncooperative pediatric patients has not been extensively elucidated. The aims are to evaluate the impact of dental treatment under GA on oral health-related quality of life (OHRQoL) in uncooperative pediatric patients with severe dental caries and to assess the effect of dental treatment under GA on children’s weight (Wt), height (Ht), Body Mass Index (BMI), and blood chemistry parameters. Methods: Forty-three uncooperative children aged 3–14 years were selected. OHRQoL, through ECOHIS (Early Childhood Oral Health Impact Scale) and COHRQoL (Child Oral Health-Related Quality of Life) questionnaires, Wt, Ht, BMI, and blood chemistry parameters were measured at baseline and eight months after dental treatment under GA. Results: At follow up, the reductions in the ECHOIS and the COHRQoL components were statistically significant (p < 0.0001), there was significant improvement in the anthropometric measures: 76.5% of children increased the percentile curves for weight, 68.6% for height, and 51.4% for BMI; for the blood chemistry parameters: ferritin improved in 68.6% of the samples, PCR in 65.7%, ESR in 68.6%, Vitamin D in 68.6%, and IGF-1 in 65.7%. Conclusions: Oral health status significantly influences OHRQoL, growth, and blood chemistry parameters in uncooperative pediatric patients.
Exploring the Role of Family and School as Spaces for 1.5 Generation South Korean’s Adjustment and Identity Negotiation in New Zealand: A Qualitative Study
Authors: Roh Su Yeon , Chang Ik Young
Published: June 2020

To date, the majority of research on migrant identity negotiation and adjustment has primarily focused on adults. However, identity- and adjustment-related issues linked with global migration are not only related to those who have recently arrived, but are also relevant for their subsequent descendants. Consequently, there is increasing recognition by that as a particular group, the “1.5 generation” who were born in their home country but came to new countries in early childhood and were educated there. This research, therefore, investigates 1.5 generation South Koreans’ adjustment and identity status in New Zealand. More specifically, this study explores two vital social spaces—family and school—which play a pivotal role in modulating 1.5 generation’s identity and adjustment in New Zealand. Drawing upon in-depth interviewing with twenty-five 1.5 generation Korean-New Zealanders, this paper reveals that there are two different experiences at home and school; (1) the family is argued to serve as a key space where the South Korean 1.5 generation confirms and retains their ethnic identity through experiences and embodiments of South Korean traditional values, but (2) school is almost the only space where the South Korean 1.5 generation in New Zealand can acquire the cultural tools of mainstream society through interaction with English speaking local peers and adults. Within this space, the South Korean 1.5 generation experiences the transformation of an ethnic sense of identity which is strongly constructed at home via the family. Overall, the paper discusses that 1.5 generation South Koreans experience a complex and contradictory process in negotiating their identity and adjusting into New Zealand through different involvement at home and school.
Transtheoretical Model Is Better Predictor of Physiological Stress than Perceived Stress Scale and Work Ability Index among Office Workers
Authors: Marin-Farrona Maria , Leon-Jimenez Manuel , Garcia-Unanue Jorge , Gallardo Leonor , Crespo-Ruiz Carmen , Crespo-Ruiz Beatriz
Published: June 2020

Physical activity impacts positively on stress and anxiety. Working conditions affect the quality of life by increasing stress levels, which can affect job performance and work absence. The Perceived Stress Scale (PSS), Work Ability Index (WAI), Transtheoretical Model (TTM), as well as heart rate variability (HRV) have been applied to monitor the state of workers in their job. The aim of this study was to analyze PSS, WAI, and TTM classifications, and to find out how are they linked to physiological stress (HRV). One hundred and thirteen office workers responded to the three questionnaires and their HRV was monitored for at least two full days. Groups were set up according to TTM (Stage 1, Stage 2, Stage 3–4, Stage 5), WAI (weak WAI, medium WAI, good WAI), and PSS (low PSS, medium PSS, high PSS). Results obtained from the test were related to stress values measured by HRV with a Bodyguard2 device. The Stage 5 group from TTM had better HVR and stress levels than the other groups for both women and men (p < 0.05). Participants in the good WAI group and low PSS group had better results than weak WAI and high PSS, but the differences with respect to medium WAI and medium PSS were less clear. Finally, TTM seemed to be the best tool to discriminate physiological stress in office workers with regard to other questionnaires.
Patterns of Interdependence between Financial Development, Fiscal Instruments, and Environmental Degradation in Developed and Converging EU Countries
Authors: Zioło Magdalena , Kluza Krzysztof , Kozuba Jarosław , Kelemen Miroslav , Niedzielski Piotr , Zinczak Paweł
Published: June 2020

Environmental risks, in particular climate change and environmental pollution, are among the key challenges faced by modern governments nowadays. Environmental risks are associated with specific costs and expenditures necessary to mitigate their negative effects. In this context, the financial system plays a significant role, particularly the public financial system, which allocates and redistributes public resources and has an impact on market participants by imposing environmental taxes. This study assessed the interdependence between environmental degradation and public expenditure, financial sector development, environmental taxes, and related socioeconomic policies. The aim was to diagnose and define the relationship between environmental degradation and sustainable fiscal instruments used in the financial system. The original research approach adopted in the study is the inclusion of variables representing a sustainable approach to assessment of the financial system. Two groups of European Union countries were analyzed for the period 2008–2017, namely, converging economies from Central and Eastern Europe and the largest developed economies of Western Europe. The authors found a strong relationship between greenhouse gas emissions and fiscal instruments, especially expenditure on research and development, and the development of the financial sector. In the case of environmental taxes, their impact differed depending on the country, being predominantly beneficial in countries with higher greenhouse gas emissions but unfavorable in countries with lower emissions levels.
Measuring School Climate among Japanese Students—Development of the Japan School Climate Inventory (JaSC)
Authors: Nishimura Tomoko , Wakuta Manabu , Tsuchiya Kenji J. , Osuka Yuko , Tamai Hideo , Takei Nori , Katayama Taiichi
Published: June 2020

School climate is a significant determinant of students’ behavioral problems and academic achievement. In this study, we developed the Japan School Climate Inventory (JaSC) to see whether it measures school climate properly. To do so, we investigated whether or not the measurement with JaSC varies across sub-groups of varying grade and of gender and examined the relationship between the perception of school climate and the psychological and behavioral traits at individual levels in a sample of Japanese elementary and junior high school students (n = 1399; grade 4–9). The results showed that the measurement was consistent, since single-factor structures, factor loadings and thresholds of the items were found not to vary across sub-groups of the participants. The participants’ perception of school climate was associated positively with quality of life, especially in school (β = 0.152, p < 0.001) and associated negatively with involvement in ijime (bullying) as “victim” and “bully/victim” (β = −0.098, p = 0.001; β = −0.188, p = 0.001, respectively) and peer relationship problems (β = −0.107, p = 0.025). JaSC was found to measure school climate consistently among varying populations of Japanese students, with satisfactory validity.
Enzyme-Antibody-Modified Gold Nanoparticle Probes for the Ultrasensitive Detection of Nucleocapsid Protein in SFTSV
Authors: Duan Yuqin , Wu Wei , Zhao Qiuzi , Liu Sihua , Liu Hongyun , Huang Mengqian , Wang Tao , Liang Mifang , Wang Zhiyun
Published: June 2020

As humans and climate change continue to alter the landscape, novel disease risk scenarios have emerged. Sever fever with thrombocytopenia syndrome (SFTS), an emerging tick-borne infectious disease first discovered in rural areas of central China in 2009, is caused by a novel bunyavirus (SFTSV). The potential for SFTS to spread to other countries in combination with its high fatality rate, possible human-to-human transmission, and extensive prevalence among residents and domesticated animals in endemic regions make the disease a severe threat to public health. Because of the lack of preventive vaccines or useful antiviral drugs, diagnosis of SFTS is the key to prevention and control of the SFTSV infection. The development of serological detection methods will greatly improve our understanding of SFTSV ecology and host tropism. We describe a highly sensitive protein detection method based on gold nanoparticles (AuNPs) and enzyme-linked immunosorbent assay (ELISA)—AuNP-based ELISA. The optical sensitivity enhancement of this method is due to the high loading efficiency of AuNPs to McAb. This enhances the concentration of the HRP enzyme in each immune sandwich structure. The detection limit of this method to the nucleocapsid protein (NP) of SFTSV was 0.9 pg mL−1 with good specificity and reproducibility. The sensitivity of AuNP-based ELISA was higher than that of traditional ELISA and was comparable to real-time quantitative polymerase chain reaction (qRT-PCR). The probes are stable for 120 days at 4 °C. This can be applied to diagnosis and hopefully can be developed into a commercial ELISA kit. The ultrasensitive detection of SFTSV will increase our understanding of the distribution and spread of SFTSV, thus helping to monitor the changes in tick-borne pathogen SFTSV risk in the environment.
Evaluation of an Oral Hygiene Education Program for Staff Providing Long-Term Care Services: A Mixed Methods Study
Authors: Wu Shang-Jung , Wang Chun-Chieh , Kuo Shu-Chen , Shieh Shwn-Huey , Hwu Yueh-Juen
Published: June 2020

Background: Oral hygiene is often neglected in clients receiving long-term care, suggesting that long-term care workers require formal oral hygiene education. Thus, the aim of this study was to investigate the effects of oral hygiene education on long-term care workers. Methods: This study utilized a mixed methods design. Eighty long-term care workers were recruited for participation in the oral hygiene education program, which employed three teaching methods: narration with multimedia presentation, demonstration, and teach-back. The effect of the education program on the participants’ level of oral hygiene knowledge, attitudes, and skills was measured using a structured questionnaire that was administered both pre- and post-delivery of the education program. Three months later, all participants submitted a self-report of their oral hygiene skills, and six participants completed a telephone interview. Quantitative data were analyzed using paired t-tests, and qualitative data were manually analyzed and coded. Results: Scores of oral hygiene knowledge (p < 0.001), attitudes (p = 0.001), and oral cleaning daily frequency for clients (p < 0.001), were significantly higher three months after undertaking the educational program. Conclusions: This preliminary study suggests that oral hygiene education may be effective in improving oral hygiene knowledge, attitudes, and skills among long-term care staff.
Overview of Neurological Mechanism of Pain Profile Used for Animal “Pain-Like” Behavioral Study with Proposed Analgesic Pathways
Authors: Yam Mun Fei , Loh Yean Chun , Oo Chuan Wei , Basir Rusliza
Published: June 2020

Pain is the most common sensation installed in us naturally which plays a vital role in defending us against severe harm. This neurological mechanism pathway has been one of the most complex and comprehensive topics but there has never been an elaborate justification of the types of analgesics that used to reduce the pain sensation through which specific pathways. Of course, there have been some answers to curbing of pain which is a lifesaver in numerous situations—chronic and acute pain conditions alike. This has been explored by scientists using pain-like behavioral study methodologies in non-anesthetized animals since decades ago to characterize the analgesic profile such as centrally or peripherally acting drugs and allowing for the development of analgesics. However, widely the methodology is being practiced such as the tail flick/Hargreaves test and Von Frey/Randall–Selitto tests which are stimulus-evoked nociception studies, and there has rarely been a complete review of all these methodologies, their benefits and its downside coupled with the mechanism of the action that is involved. Thus, this review solely focused on the complete protocol that is being adapted in each behavioral study methods induced by different phlogogenic agents, the different assessment methods used for phasic, tonic and inflammatory pain studies and the proposed mechanism of action underlying each behavioral study methodology for analgesic drug profiling. It is our belief that this review could significantly provide a concise idea and improve our scientists’ understanding towards pain management in future research.
Characterisation of the Effect of the Spatial Organisation of Hemicellulases on the Hydrolysis of Plant Biomass Polymer
Authors: Enjalbert Thomas , De La Mare Marion , Roblin Pierre , Badruna Louise , Vernet Thierry , Dumon Claire , Montanier Cédric Y.
Published: June 2020

Synergism between enzymes is of crucial importance in cell metabolism. This synergism occurs often through a spatial organisation favouring proximity and substrate channelling. In this context, we developed a strategy for evaluating the impact of the geometry between two enzymes involved in nature in the recycling of the carbon derived from plant cell wall polymers. By using an innovative covalent association process using two protein fragments, Jo and In, we produced two bi-modular chimeric complexes connecting a xylanase and a xylosidase, involved in the deconstruction of xylose-based plant cell wall polymer. We first show that the intrinsic activity of the individual enzymes was preserved. Small Angle X-rays Scattering (SAXS) analysis of the complexes highlighted two different spatial organisations in solution, affecting both the distance between the enzymes (53 Å and 28 Å) and the distance between the catalytic pockets (94 Å and 75 Å). Reducing sugar and HPAEC-PAD analysis revealed different behaviour regarding the hydrolysis of Beechwood xylan. After 24 h of hydrolysis, one complex was able to release a higher amount of reducing sugar compare to the free enzymes (i.e., 15,640 and 14,549 µM of equivalent xylose, respectively). However, more interestingly, the two complexes were able to release variable percentages of xylooligosaccharides compared to the free enzymes. The structure of the complexes revealed some putative steric hindrance, which impacted both enzymatic efficiency and the product profile. This report shows that controlling the spatial geometry between two enzymes would help to better investigate synergism effect within complex multi-enzymatic machinery and control the final product.
Sialic Acid-Siglec Axis as Molecular Checkpoints Targeting of Immune System: Smart Players in Pathology and Conventional Therapy
Authors: Wielgat Przemyslaw , Rogowski Karol , Niemirowicz-Laskowska Katarzyna , Car Halina
Published: June 2020

The sialic acid-based molecular mimicry in pathogens and malignant cells is a regulatory mechanism that leads to cross-reactivity with host antigens resulting in suppression and tolerance in the immune system. The interplay between sialoglycans and immunoregulatory Siglec receptors promotes foreign antigens hiding and immunosurveillance impairment. Therefore, molecular targeting of immune checkpoints, including sialic acid-Siglec axis, is a promising new field of inflammatory disorders and cancer therapy. However, the conventional drugs used in regular management can interfere with glycome machinery and exert a divergent effect on immune controlling systems. Here, we focus on the known effects of standard therapies on the sialoglycan-Siglec checkpoint and their importance in diagnosis, prediction, and clinical outcomes.
Biological Functions and Therapeutic Potential of Lipocalin 2 in Cancer
Authors: Santiago-Sánchez Ginette S. , Pita-Grisanti Valentina , Quiñones-Díaz Blanca , Gumpper Kristyn , Cruz-Monserrate Zobeida , Vivas-Mejía Pablo E.
Published: June 2020

Lipocalin-2 (LCN2) is a secreted glycoprotein linked to several physiological roles, including transporting hydrophobic ligands across cell membranes, modulating immune responses, maintaining iron homeostasis, and promoting epithelial cell differentiation. Although LNC2 is expressed at low levels in most human tissues, it is abundant in aggressive subtypes of cancer, including breast, pancreas, thyroid, ovarian, colon, and bile duct cancers. High levels of LCN2 have been associated with increased cell proliferation, angiogenesis, cell invasion, and metastasis. Moreover, LCN2 modulates the degradation, allosteric events, and enzymatic activity of matrix metalloprotease-9, a metalloprotease that promotes tumor cell invasion and metastasis. Hence, LCN2 has emerged as a potential therapeutic target against many cancer types. This review summarizes the most relevant findings regarding the expression, biological roles, and regulation of LCN2, as well as the proteins LCN2 interacts with in cancer. We also discuss the approaches to targeting LCN2 for cancer treatment that are currently under investigation, including the use of interference RNAs, antibodies, and gene editing.
Anti-Cancer Effects of CKD-581, a Potent Histone Deacetylase Inhibitor against Diffuse Large B-Cell Lymphoma
Authors: Kim Soo Jin , Kim U Ji , Yoo Hae Yong , Choi Yong June , Kang Keon Wook
Published: June 2020

Double-hit lymphoma (DHL) and double-expressor lymphoma (DEL) are aggressive forms of lymphoma that require better treatments to improve patient outcomes. CKD-581 is a new histone deacetylase (HDAC) inhibitor that exhibited a better safety profile in clinical trials compared to other HDAC inhibitors. Here, we demonstrate that CKD-581 inhibited the class I–II HDAC family via histone H3 and tubulin acetylation. CKD-581 treatment also up-regulated the phosphorylation of histone H2AX (γH2AX, DNA double-strand break marker), and reduced levels of MYC and anti-apoptotic proteins such as BCL-2, BCL-6, BCL-XL, and MCL-1 in DH/DE-diffuse large B cell lymphoma (DLBCL) cell lines. Ultimately, CKD-581 also induced apoptosis via poly(ADP ribose) polymerase 1 (PARP1) cleavage. In a DLBCL SCID mouse xenograft model, CKD-581 exhibited anti-cancer effects comparable with those of rituximab (CD20 mAb). Our findings suggest that CKD-581 could be a good candidate for the treatment of DLBCL.
Discovery of Isoplumbagin as a Novel NQO1 Substrate and Anti-Cancer Quinone
Authors: Tsao Yen-Chi , Chang Yu-Jung , Wang Chun-Hsien , Chen Linyi
Published: June 2020

Isoplumbagin (5-hydroxy-3-methyl-1,4-naphthoquinone), a naturally occurring quinone from Lawsonia inermis and Plumbago europaea, has been reported to have anti-inflammatory and antimicrobial activity. Inflammation has long been implicated in cancer progression. In this study, we examined the anticancer effect of chemically synthesized isoplumbagin. Our results revealed that isoplumbagin treatment suppressed cell viability and invasion of highly invasive oral squamous cell carcinoma (OSCC) OC3-IV2 cells, glioblastoma U87 cells, non-small cell lung carcinoma H1299 cells, prostate cancer PC3 cells, and cervical cancer HeLa cells by using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and Boyden chamber assays. In vivo studies demonstrate the inhibitory effect of 2 mg/kg isoplumbagin on the growth of orthotopic xenograft tumors derived from OSCC cells. Mechanistically, isoplumbagin exerts its cytotoxic effect through acting as a substrate of reduced nicotinamide adenine dinucleotide phosphate [NAD(P)H] dehydrogenase quinone 1 (NQO1) to generate hydroquinone, which reverses mitochondrial fission phenotype, reduces mitochondrial complex IV activity, and thus compromises mitochondrial function. Collectively, this work reveals an anticancer activity of isoplumbagin mainly through modulating mitochondrial dynamics and function.
OsJAZ13 Negatively Regulates Jasmonate Signaling and Activates Hypersensitive Cell Death Response in Rice
Authors: Feng Xiujing , Zhang Lei , Wei Xiaoli , Zhou Yun , Dai Yan , Zhu Zhen
Published: June 2020

Jasmonate ZIM-domain (JAZ) proteins belong to the subgroup of TIFY family and act as key regulators of jasmonate (JA) responses in plants. To date, only a few JAZ proteins have been characterized in rice. Here, we report the identification and function of rice OsJAZ13 gene. The gene encodes three different splice variants: OsJAZ13a, OsJAZ13b, and OsJAZ13c. The expression of OsJAZ13 was mainly activated in vegetative tissues and transiently responded to JA and ethylene. Subcellular localization analysis indicated OsJAZ13a is a nuclear protein. Yeast two-hybrid assays revealed OsJAZ13a directly interacts with OsMYC2, and also with OsCOI1, in a COR-dependent manner. Furthermore, OsJAZ13a recruited a general co-repressor OsTPL via an adaptor protein OsNINJA. Remarkably, overexpression of OsJAZ13a resulted in the attenuation of root by methyl JA. Furthermore, OsJAZ13a-overexpressing plants developed lesion mimics in the sheath after approximately 30–45 days of growth. Tillers with necrosis died a few days later. Gene-expression analysis suggested the role of OsJAZ13 in modulating the expression of JA/ethylene response-related genes to regulate growth and activate hypersensitive cell death. Taken together, these observations describe a novel regulatory mechanism in rice and provide the basis for elucidating the function of OsJAZ13 in signal transduction and cell death in plants.
The Role of MET Inhibitor Therapies in the Treatment of Advanced Non-Small Cell Lung Cancer
Authors: De Mello Ramon Andrade , Neves Nathália Moisés , Amaral Giovanna Araújo , Lippo Estela Gudin , Castelo-Branco Pedro , Pozza Daniel Humberto , Tajima Carla Chizuru , Antoniou Georgios
Published: June 2020

Introduction: Non-small cell lung cancer (NSCLC) is the second most common cancer globally. The mesenchymal-epithelial transition (MET) proto-oncogene can be targeted in NSCLC patients. Methods: We performed a literature search on PubMed in December 2019 for studies on MET inhibitors and NSCLC. Phase II and III clinical trials published in English between 2014 and 2019 were selected. Results: Data on MET inhibitors (tivantinib, cabozantinib, and crizotinib) and anti-MET antibodies (emibetuzumab and onartuzumab) are reported in the text. Conclusion: Emibetuzumab could be used for NSCLC cases with high MET expression. Further, studies on onartuzumab failed to prove its efficacy, while the results of tivantinib trials were clinically but not statistically significant. Additionally, cabozantinib was effective, but adverse reactions were common, and crizotinib was generally well-tolerated.
Adherence to Anti-Viral Treatment for Chronic Hepatitis B
Authors: Abu-Freha Naim , Abu Tailakh Muhammad , Fich Alexander , Abu Bader Nasreen , Shemer-Avni Yonat , Alsana Farhan , Gasper Nava , Abu-Kaf Heba , Etzion Ohad
Published: June 2020

Adherence to treatment of chronic Hepatitis B Virus (HBV) is an important issue and can affect the complication rate. Nucleos(t)ide analogue as oral treatments are used for patients with necro-inflammatory activity and high viral load, with the goal of decline the complication rate such cirrhosis and hepatic cancer. We aimed to investigate the adherence to chronic HBV treatment. Chronic HBV patients with dispensing medication rates (DMR) of at least 80% were defined as high adherence group (HAG) and those who dispensed less than 80% as low adherence group (LAG). The study included 273 patients. 90 patients (33%) were in the LAG and 183 (67%) in the HAG. The All-cause mortality in the LAG was 15.6%, and 8.7% among the HAG (p-value = 0.09). 185 patients were of Jewish origin (mean age of 52.96 ±14.6 years, 30% women) and 88 patients of Arab Bedouin (AB) origin (mean age of 40.86 ± 13.96 years (p-value < 0.001), 42% women). The proportion of Jewish patients with high adherence was 71% (131 patients) versus 59% (52 patients) in AB patients (p-value = 0.054). The all-causes mortality was 14.6% among Jewish origin and 3.4% of AB (p-value = 0.01). We conclude that, two third of HBV carriers are with high level adherence to treatment in southern Israel, with lower but marginally significant all-cause mortality. No-significant differences in adherence patterns were noted between Arab Bedouin and Jews.
The Effect of Cellular Coenzyme Q10 Deficiency on Lysosomal Acidification
Authors: Heaton Robert A. , Heales Simon , Rahman Khalid , Sexton Darren W. , Hargreaves Iain
Published: June 2020

Coenzyme Q10 (CoQ10) deficiency currently represents the only treatable mitochondrial disorder, however, little is known about how it may affect other organelles. The lysosome has been found to have a large concentration of CoQ10 localised at its membrane; additionally, it has been suggested that it plays a role in the normal acidification of the lysosomal lumen. As a result, in this study we assessed the effect of CoQ10 deficiency on lysosomal acidification. In order to investigate this, a neuronal cell model of CoQ10 deficiency was established via the treatment of SH-SY5Y cells with para-aminobenzoic acid (PABA). This method works through the competitive inhibition of the CoQ10 biosynthetic pathway enzyme, CoQ2. A single 1 mM (5 days) treatment with PABA resulted in a decrease of up to 58% in cellular CoQ10 (p < 0.05). It was found that this resulted in a significant decrease in fluorescence of both the LysoSensor (23%) and LysoTracker (35%) probes used to measure lysosomal pH (p < 0.05). It was found that subsequent treatment with CoQ10 (5 µM, 3 days) was able to restore cellular CoQ10 concentration (p < 0.005), which was associated with an increase in fluorescence from both probes to around 90% of controls (p < 0.05), suggesting a restoration of lysosomal pH. This study provides insights into the association between lysosomal pH and cellular CoQ10 status and the possibility that a deficit in the status of this isoprenoid may result in an impairment of lysosomal acidification.
Prospective Association of Air-Purifier Usage during Pregnancy with Infant Neurodevelopment: A Nationwide Longitudinal Study—Japan Environment and Children’s Study (JECS)
Authors: Matsumura Kenta , Hamazaki Kei , Tsuchida Akiko , Inadera Hidekuni ,   The Japan Environment and Children’s Study (JECS) Group
Published: June 2020

Fetal exposure to particulate matter (PM) is associated with infant developmental delay likely via neuroinflammation and prefrontal cortex lesions; however, whether air-purifier usage, which can reduce indoor PM levels, is related to infant developmental delay remains unknown. We therefore examined the prospective relationship between air-purifier usage during pregnancy and infant developmental delay by analyzing 82,441 mother–infant pairs using a simple yes/no questionnaire. Developmental delays at 6 and 12 months were assessed in five areas using the Ages and Stages Questionnaire, Third Edition. A generalized linear mixed model analysis was used to derive adjusted odds ratios (AORs) and 95% confidence intervals (95% CIs) while controlling for 20 covariates. The analysis revealed that air-purifier usage was associated with developmental delays in fine motor (AOR: 0.91, 95% CI: 0.83–0.99) and problem solving (AOR: 0.83, 95% CI: 0.77–0.90) at 6 months and in communication (AOR: 0.86, 95% CI: 0.79–0.93), fine motor (AOR: 0.87, 95% CI: 0.82–0.92), problem solving (AOR: 0.83, 95% CI: 0.77–0.88), and personal–social (AOR: 0.79, 95% CI: 0.72–0.86) at 12 months. In conclusion, a negative association exists between air-purifier usage during pregnancy and infant neurodevelopmental delay that strengthens with time. Our results outline the potential role of air purifiers in inhibiting infant neurodevelopmental delay.
The Effects of MELD-Based Liver Allocation on Patient Survival and Waiting List Mortality in a Country with a Low Donation Rate
Authors: Ritschl Paul V. , Wiering Leke , Dziodzio Tomasz , Jara Maximilian , Kruppa Jochen , Schoeneberg Uwe , Raschzok Nathanael , Butz Frederike , Globke Brigitta , Seika Philippa , Maurer Max , Biebl Matthias , Schöning Wenzel , Schmelzle Moritz , Sauer Igor M. , Tacke Frank , Öllinger Robert , Pratschke Johann
Published: June 2020

The Model for End-Stage Liver Disease (MELD)-based allocation system was implemented in Germany in 2006 in order to reduce waiting list mortality. The purpose of this study was to evaluate post-transplant results and waiting list mortality since the introduction of MELD-based allocation in our center and in Germany. Adult liver transplantation at the Charité—Universitätsmedizin Berlin was assessed retrospectively between 2005 and 2012. In addition, open access data from Eurotransplant (ET) and the German Organ Transplantation Foundation (DSO) were evaluated. In our department, 861 liver transplantations were performed from 2005 to 2012. The mean MELD score calculated with the laboratory values last transmitted to ET before organ offer (labMELD) at time of transplantation increased to 20.1 from 15.8 (Pearson’s R = 0.121, p < 0.001, confidence interval (CI) = 0.053–0.187). Simultaneously, the number of transplantations per year decreased from 139 in 2005 to 68 in 2012. In order to overcome this organ shortage the relative number of utilized liver donors in Germany has increased (85% versus 75% in non-German ET countries). Concomitantly, 5-year patient survival decreased from 79.9% in 2005 to 60.3% in 2012 (p = 0.048). At the same time, the ratio of waiting list mortality vs. active-listed patients nearly doubled in Germany (Spearman’s rho = 0.903, p < 0.001, CI = 0.634–0.977). In low-donation areas, MELD-based liver allocation may require reconsideration and inclusion of prognostic outcome factors.
Peridynamic Mindlin Plate Formulation for Functionally Graded Materials
Authors: Yang Zhenghao , Oterkus Erkan , Oterkus Selda
Published: June 2020

In this study, a new peridynamic Mindlin plate formulation is presented which is suitable for the analysis of functionally graded materials. The governing equations of peridynamic formulation are obtained by using Euler-Lagrange equations in conjunction with Taylor’s expansion. To validate the new formulation, three different numerical benchmark problems are considered for a Mindlin plate subjected to simply supported, fully clamped and mixed (clamped-simply supported) boundary conditions. Peridynamic results are compared against results from finite element analysis and a good agreement is observed between the two methods.
Extreme Weather and Climate Events: Physical Drivers, Modeling and Impact Assessment
Authors: Zhang Wei , Yang Xiaosong
Published: June 2020

Extreme weather and climate events, including hurricanes [...]
Open Sensor Manager for IIoT
Authors: Ala-Laurinaho Riku , Autiosalo Juuso , Tammi Kari
Published: June 2020

Data collection in an industrial environment enables several benefits: processes and machinery can be monitored; the performance can be optimized; and the machinery can be proactively maintained. To collect data from machines or production lines, numerous sensors are required, which necessitates a management system. The management of constrained IoT devices such as sensor nodes is extensively studied. However, the previous studies focused only on the remote software updating or configuration of sensor nodes. This paper presents a holistic Open Sensor Manager (OSEMA), which addresses also generating software for different sensor models based on the configuration. In addition, it offers a user-friendly web interface, as well as a REST API (Representational State Transfer Application Programming Interface) for the management. The manager is built with the Django web framework, and sensor nodes rely on ESP32-based microcontrollers. OSEMA enables secure remote software updates of sensor nodes via encryption and hash-based message authentication code. The collected data can be transmitted using the Hypertext Transfer Protocol (HTTP) and Message Queuing Telemetry Transport (MQTT). The use of OSEMA is demonstrated in an industrial domain with applications estimating the usage roughness of an overhead crane and tracking its location. OSEMA enables retrofitting different sensors to existing machinery and processes, allowing additional data collection.
Recent Trends in Applying Ortho-Nitrobenzyl Esters for the Design of Photo-Responsive Polymer Networks
Authors: Romano Angelo , Roppolo Ignazio , Rossegger Elisabeth , Schlögl Sandra , Sangermano Marco
Published: June 2020

Polymers with light-responsive groups have gained increased attention in the design of functional materials, as they allow changes in polymers properties, on demand, and simply by light exposure. For the synthesis of polymers and polymer networks with photolabile properties, the introduction o-nitrobenzyl alcohol (o-NB) derivatives as light-responsive chromophores has become a convenient and powerful route. Although o-NB groups were successfully exploited in numerous applications, this review pays particular attention to the studies in which they were included as photo-responsive moieties in thin polymer films and functional polymer coatings. The review is divided into four different sections according to the chemical structure of the polymer networks: (i) acrylate and methacrylate; (ii) thiol-click; (iii) epoxy; and (iv) polydimethylsiloxane. We conclude with an outlook of the present challenges and future perspectives of the versatile and unique features of o-NB chemistry.
PLAGA-PEG-PLAGA Terpolymer-Based Carriers of Herbicides for Potential Application in Environment-Friendly, Controlled Release Systems of Agrochemicals
Authors: Lewicka Kamila , Dobrzynski Piotr , Rychter Piotr
Published: June 2020

The present study aimed to develop and prepare new polymer/herbicide formulations for their potential application in environment-friendly, controlled release systems of agrochemicals. Selected biodegradable polymers, including L-Lactide/Glycolide/PEG/Terpolymer (PLAGA-PEG-PLAGA) as well as oligosaccharide-based polymers and their blend with terpolymer, were used to prepare microspheres loaded with two soil-applied herbicides. The degradation process of the obtained polymeric microspheres was evaluated based on (1) their weight loss and surface erosion and (2) the release rate of loaded metazachlor and pendimethalin. The herbicidal effectiveness of the herbicides released to the soil from microspheres was evaluated using the European Weed Research Council (EWRC) rating scale. Moreover, the ecotoxicological effect of herbicide-loaded microspheres buried in soil on the marine bacterial species A. fischeri was assessed. It was found that the gradual degradation rate of microparticles led to the prolonged release of both herbicides that lasted for a few months, i.e., for the entire crop season, which is crucial in terms of agrochemical and environmental protection. Maltodextrin- and dextrin-based microspheres showed higher susceptibility to degradation than terpolymer-based microspheres. The microencapsulation of herbicides protected them from decomposition and excessive leaching into soil and maintained their activity for a longer period than that for non-immobilized herbicides. The ecotoxicological assessment on A. fischeri demonstrated that the proposed microsphere-encapsulated herbicides were less toxic than non-immobilized herbicides.
Trace Organic Compound Removal from Wastewater Reverse-Osmosis Concentrate by Advanced Oxidation Processes with UV/O3/H2O2
Authors: Kaplan Aviv , Mamane Hadas , Lester Yaal , Avisar Dror
Published: June 2020

Advanced technologies, such as reverse osmosis (RO), allow the reuse of treated wastewater for direct or indirect potable use. However, even highly efficient RO systems produce ~10–15% highly contaminated concentrate as a byproduct. This wastewater RO concentrate (WWROC) is very rich in metal ions, nutrients, and hard-to-degrade trace organic compounds (TOrCs), such as pharmaceuticals, plasticizers, flame retardants, and detergents, which must be treated before disposal. WWROC could be up to 10 times more concentrated than secondary effluent. We examined the efficiency of several advanced oxidation processes (AOPs) on TOrC removal from a two-stage WWROC matrix in a pilot wastewater-treatment facility. WWROC ozonation or UV irradiation, with H2O2 addition, demonstrated efficient removal of TOrCs, varying between 21% and over 99% degradation, and indicating that radical oxidation (by HO·) is the dominant mechanism. However, AOPs are not sufficient to fully treat the WWROC, and thus, additional procedures are required to decrease metal ion and nutrient concentrations. Further biological treatment post-AOP is also highly important, to eliminate the degradable organic molecules obtained from the AOP.
A New Machine Learning Algorithm Based on Optimization Method for Regression and Classification Problems
Authors: Inthakon Warunun , Suantai Suthep , Sarnmeta Panitarn , Chumpungam Dawan
Published: June 2020

A convex minimization problem in the form of the sum of two proper lower-semicontinuous convex functions has received much attention from the community of optimization due to its broad applications to many disciplines, such as machine learning, regression and classification problems, image and signal processing, compressed sensing and optimal control. Many methods have been proposed to solve such problems but most of them take advantage of Lipschitz continuous assumption on the derivative of one function from the sum of them. In this work, we introduce a new accelerated algorithm for solving the mentioned convex minimization problem by using a linesearch technique together with a viscosity inertial forward–backward algorithm (VIFBA). A strong convergence result of the proposed method is obtained under some control conditions. As applications, we apply our proposed method to solve regression and classification problems by using an extreme learning machine model. Moreover, we show that our proposed algorithm has more efficiency and better convergence behavior than some algorithms mentioned in the literature.
On a Laminated Timoshenko Beam with Nonlinear Structural Damping
Authors: Apalara Tijani A. , Nass Aminu M. , Al Sulaimani Hamdan
Published: June 2020

In the present work, we study a one-dimensional laminated Timoshenko beam with a single nonlinear structural damping due to interfacial slip. We use the multiplier method and some properties of convex functions to establish an explicit and general decay result. Interestingly, the result is established without any additional internal or boundary damping term and without imposing any restrictive growth assumption on the nonlinear term, provided the wave speeds of the first equations of the system are equal.
Numerical Approach to a Nonlocal Advection-Reaction-Diffusion Model of Cartilage Pattern Formation
Authors: Glimm Tilmann , Zhang Jianying
Published: June 2020

We propose a numerical approach that combines a radial basis function (RBF) meshless approximation with a finite difference discretization to solve a nonlinear system of integro-differential equations. The equations are of advection-reaction-diffusion type modeling the formation of pre-cartilage condensations in embryonic chicken limbs. The computational domain is four dimensional in the sense that the cell density depends continuously on two spatial variables as well as two structure variables, namely membrane-bound counterreceptor densities. The biologically proper Dirichlet boundary conditions imposed in the semi-infinite structure variable region is in favor of a meshless method with Gaussian basis functions. Coupled with WENO5 finite difference spatial discretization and the method of integrating factors, the time integration via method of lines achieves optimal complexity. In addition, the proposed scheme can be extended to similar models with more general boundary conditions. Numerical results are provided to showcase the validity of the scheme.
Can the Computed Tomographic Aspect of Porto-Systemic Circulation in Cirrhotic Patients Be Associated with the Presence of Variceal Hemorrhage?
Authors: Caraiani Cosmin , Petresc Bianca , Pop Anamaria , Rotaru Magda , Ciobanu Lidia , Ștefănescu Horia
Published: June 2020

Background and objectives: Variceal bleeding is a serious complication caused by portal hypertension, frequently encountered among cirrhotic patients. The purpose of this study was to determine whether the aspect of the collateral, porto-systemic circulation, as detected by CT are associated with the presence variceal hemorrhage (VH). Materials and Methods: 81 cirrhotic patients who underwent a contrast-enhanced CT examination were retrospectively included in the study. Patients were divided into two groups: Cirrhotic patients with variceal hemorrhage during the hospital admission concomitant, with the CT examination (n = 33) and group 2-cirrhotic patients, without any variceal hemorrhage in their medical history (n = 48). The diameter of the left gastric vein, the presence or absence and dimensions of oesophageal and gastric varices, paraumbilical veins and splenorenal shunts were the indicators assessed on CT. Results: The univariate analysis showed a significant association between the presence of upper GI bleeding and the diameters of paraoesophageal veins, paragastric veins and left gastric vein respectively, all of these CT parameters being higher in patients with variceal bleeding. In the multivariate logistic regression analysis, only the diameter of the left gastric vein was independently associated with the presence of variceal hemorrhage (OR = 1.6 (95% CI: 1.17–2.19), p = 0.003). We found an optimal cut-off value of 3 mm for the diameter of the left gastric vein useful to discriminate among patients with variceal hemorrhage from the ones without it, with a good diagnostic performance (AUC = 0.78, Se = 97%, Sp = 45.8%, PPV = 55.2%, NPV = 95.7%). Conclusions: Our observations point out that an objective CT quantification of porto-systemic circulation can be correlated with the presence of variceal hemorrhage and the diameter of the left gastric vein can be a reliable parameter associated with this condition.
Effect of Rapid Quenching on the Solidification Microstructure, Tensile Properties and Fracture of Secondary Hypereutectic Al-18%Si-2%Cu Alloy
Authors: Chaus Alexander , Marukovich Evgeny , Sahul Martin
Published: June 2020

In this work, the effect of rapid quenching from the partially liquid and solid condition is studied on the as-cast microstructure, tensile properties and fracture features of a secondary hypereutectic Al-18%Si-2%Cu alloy. For comparison purposes, the same ingots of 50 mm in diameter and 300 mm in height were also fabricated using conventional chill casting. The microstructure of the samples was subjected to detailed characterisation using scanning electron microscope (SEM) and energy-dispersive X-ray spectroscopy (EDX) analyses. The tensile properties and fracture were also evaluated. A significant grain refinement of the eutectic constituents (α (Al) + Si), as well as primary silicon and intermetallics accompanying coarse plate and Chinese script with a well-dispersed morphology transition for the intermetallics, was observed in the alloy subjected to the rapid quenching. The connection between primary and eutectic silicon was shown metallographically, confirming the fact that primary silicon served as a nuclei site for eutectic silicon. The microstructure refinement, together with a favourable morphology transition, resulted in greatly enhanced tensile properties and the more ductile fracture behaviour of the studied alloy.
Lignans, Amides, and Saponins from Haplophyllum tuberculatum and Their Antiprotozoal Activity
Authors: Mahmoud Abdelhalim Babiker , Danton Ombeline , Kaiser Marcel , Han Sohee , Moreno Aitor , Abd Algaffar Shereen , Khalid Sami , Oh Won Keun , Hamburger Matthias , Mäser Pascal
Published: June 2020

A screening of Sudanese medicinal plants for antiprotozoal activities revealed that the chloroform and water fractions of the ethanolic root extract of Haplophyllum tuberculatum exhibited appreciable bioactivity against Leishmania donovani. The antileishmanial activity was tracked by HPLC-based activity profiling, and eight compounds were isolated from the chloroform fraction. These included lignans tetrahydrofuroguaiacin B (1), nectandrin B (2), furoguaiaoxidin (7), and 3,3′-dimethoxy-4,4′-dihydroxylignan-9-ol (10), and four cinnamoylphenethyl amides, namely dihydro-feruloyltyramine (5), (E)-N-feruloyltyramine (6), N,N′-diferuloylputrescine (8), and 7′-ethoxy-feruloyltyramine (9). The water fraction yielded steroid saponins 11–13. Compounds 1, 2, and 5–13 are reported for the first time from Haplophyllum species and the family Rutaceae. The antiprotozoal activity of the compounds plus two stereoisomeric tetrahydrofuran lignans—fragransin B2 (3) and fragransin B1 (4)—was determined against Leishmania donovani amastigotes, Plasmodium falciparum, and Trypanosoma brucei rhodesiense bloodstream forms, along with their cytotoxicity to rat myoblast L6 cells. Nectandrin B (2) exhibited the highest activity against L. donovani (IC50 4.5 µM) and the highest selectivity index (25.5).