bluuebunny/crossref_metadata_2025 huggingface dataset:
The Preparation of Au NPs/RGO-MoO 2 Composite Modified Electrode and Simultaneous Detection of Acetaminophen and Dopamine
Authors: Gu Jiang-dong , An Qiu-feng , Yang Wu , Pang Ling-yan , He Ya-fei
Published: September 2021

Dopamine (DA) exists in human body fluids and is the most basic metabolite of the human body, and it is an important neurotransmitter in the central nervous system of animals. Acetaminophen (AMP) is commonly used as cold medicine to treat fever and relieve pain. The safe dosage is very important to human health. Therefore, it is very important to construct an accurate, efficient and fast detection method for detecting AMP and DA. In this paper, Au NPs/RGO-MoO 2 composite modified electrode was prepared for the detection of AMP and DA , We can see that the synergy between RGO-MoO 2 nanomaterials and Au NPs and can promote the electrochemical reaction of AMP and DA, and the oxidation peak potential difference is greater than 180 mV. The linear range of the sensor for detecting AMP is 0.05~320 μmol/L while the linear range of DA is 0.6~260 μmol/L, and the detection limits are 7.2 nmol/L and 13 nmol/L (S/N=3) respectively. The Au NPs/ RGO-MoO 2 /GCE sensor can be used for the detection of AMP and DA in actual samples because of its excellent characteristics such as wide linear range, lower detection limit, excellent reproducibility, stability, and high selectivity
Pharmacognostic Identification of the Green Peel of Juglans mandshurica Maxim. from Different Regions and Harvest Times
Authors: Chen Jielin , Wang Chao , Yan Yongjie , Wang Lihong
Published: September 2021

Background: The green peel of Juglans mandshurica Maxim. (QLY) can be used as medicine, also known as Qinglongyi[1]. The aim of this study was to identify QLY from the different regions and harvest times by pharmacognostic identification.Methods: In this study, the morphological character, microscopic character and juglone’s content of QLY from different regions and harvest times were compared by morphological identification, paraffin section and powder section, physico-chemical identification and High Performance Liquid Chromatography (HPLC).Results: Morphological identification results that the colour of outer surfaces of peels which harvested from Tangyuan county of Heilongjiang Province in July, August and September are respectively yellow brown, tan and black brown , and the color of the solution graded gradually from light brown yellow to brownish black by water-based test (WBT). The colour of outer surfaces of peels which harvested from Changbai county of Jilin Province in July, August and September are respectively yellowish white, brownish yellow and pale brown, and the color of the solution gradually changed from light brown to dark brown by WBT. As well as the colour of outer surfaces of peels which harvested from Qingyuan county of Liaoning Province in July, August and respectively September are Light yellowish green, light brownish green and brown green, and the color of the solution gradually changed from light green to dark brown by WBT. With the increase of growth period, the number of microscopic characteristics of different Qinglongyi increased. Through physico-chemical identification, it was found that the yield of juglone in QLY picked on September 21, 2016 was the highest, and the content of juglone, whose order was Heilongjiang > Jilin > Liaoning, was as high as 203.476 μg/g.Conclusions: Through comparison, it is concluded that Heilongjiang Province is one of the high-quality producing areas of QLY, and its best harvest time is in the middle and first ten-day period of September to harvest QLY without softening, yellowing and decay. This experiment provides a theoretical basis for the determination of the best harvest conditions in QLY and the establishment of identification standards for medicinal materials.
Randomized Double-blind Placebo-controlled Proof-of-concept Trial of Resveratrol for Outpatient Treatment of Mild Coronavirus Disease (COVID-19)
Authors: McCreary Marvin R. , Schnell Patrick M. , Rhoda Dale A.
Published: September 2021

Resveratrol is a polyphenol that has been well studied and has demonstrated anti-viral and anti-inflammatory properties that might mitigate the effects of COVID-19. Outpatients (N=105) were recruited from central Ohio in late 2020. Participants were randomly assigned to receive placebo or resveratrol. Both groups received a single dose of Vitamin D3 which was used as an adjunct. The primary outcome measure was hospitalization within 21 days of symptom onset; secondary measures were ER visits, incidence of pneumonia and pulmonary embolism. Five patients chose not to participate after randomization. Twenty-one day outcome was determined of all one hundred participants (mean [SD] age 55.6 [8.8] years; 61% female) (or their surrogates). There were no clinically significant adverse events attributed to resveratrol. Outpatients in this phase 2 study treated with resveratrol had a lower incidence compared to placebo of: hospitalization (2% vs. 6%, RR 0.33, 95% CI 0.04-3.10), COVID-related ER visits (8% vs. 14%, RR 0.57, 95% CI 0.18-1.83), and pneumonia (8% vs. 16%, RR 0.5, 95% CI 0.16-1.55). One patient (2%) in each group developed pulmonary embolism (RR 1.00, 95% CI: 0.06-15.55). This underpowered study was limited by small sample size and low incidence of primary adverse events. A larger trial could determine efficacy.TRIAL REGISTRATIONS: ClinicalTrials.gov NCT04400890 26/05/2020; FDA IND #150033 05/05/2020
Comparison of the Effects of Different Regional Blockade Techniques on Occurrence of Acute Kidney Injury (AKI) After Major Thoracic and Abdominal Surgeries Under General Anesthesia: A Propensity Matching Analysis
Authors: Zhang Feng , Zhou Yan , Liu Si
Published: September 2021

Background: Recently, it has been under consideration that the anesthetic techniques used during general anesthesia may have influence over the development of acute kidney injury and other postoperative outcomes. For this reason, we aimed to compare the effects of different regional blockade techniques (peripheral nerve blockade versus neuraxial epidural) on occurrence of acute kidney injury (AKI) after thoracic and abdominal surgeries under general anesthesia.Methods: In a single-center retrospective cohort study, 2846 patients undergoing elective thoracic or abdominal surgery during a period of seven years were included into the study. The primary endpoint was the occurrence of AKI postoperatively within a seven-day period in-hospital. Perioperative data were obtained and analyzed to provide data for secondary endpoints that include all other outcome related parameters. To reduce the influence of potential confounding factors, propensity score (PS) analysis was performed. Multivariate logistic regression models examined the selection of an epidural or PNB in general anesthesia before and after propensity score weighting analysis.Results: Of the 2846 patients, 7.3% (207 cases) suffered AKI. The odds ratio of AKI for PNB (epidural as reference) was 0.61 (0.40~0.83), P = 0.006. After propensity score matching, the odds ratio for PNB was [0.49 (0.28~0.70), P = 0.001]. All other outcome related parameters were considered and evaluated.Conclusions: After PS matching analysis, there is no difference in secondary outcome analysis of groups that received PNB or epidural neuraxial blockade who were both under general anesthesia. However, patients who received PNB under general anesthesia showed lower incidence of AKI within seven days postoperatively.
An Equity Analysis on the Household Costs of Accessing and Utilising Primary Health Care Services in Tanzania
Authors: Binyaruka Peter , Borghi Josephine
Published: September 2021

Background: Direct and time costs of accessing and using health care may limit health care access, affect welfare loss, and lead to catastrophic spending especially among poorest households. To date, limited attention has been given to time and transport costs and how these costs are distributed across patients, facility and service types especially in poor settings. We aimed to fill this knowledge gap.Methods: We used data from 1407 patients in 150 facilities in Tanzania. Data were collected in January 2012 through patient exit-interviews. All costs were disaggregated across patients, facility and service types. Data were analysed descriptively by using means, medians and equity measures like equity gap, ratio and concentration index. Results: 71% of patients, especially the poorest and rural patients, accessed care on foot. The average travel time and cost were 30 minutes and 0.41USD respectively. The average waiting time and consultation time were 47 minutes and 13 minutes respectively. The average medical cost was 0.23 USD but only18% of patients paid for health care. The poorest and rural patients faced substantial time burden to access health care (travel and waiting) but incurred less transport and medical costs compared to their counterparts. The consultation time was almost similar across patients. Patients spent more time travelling to public facilities and dispensaries while incurring less transport cost than accessing other facility types, but waiting and consultation time was almost similar across facility types. Patients spent more time travelling to public facilities and dispensaries with less transport cost than accessing other facility types. Patients paid less amount in public than in private facilities. Postnatal care and vaccination clients spent less waiting and consultation time and paid less medical cost than antenatal care clients. Conclusions: Our findings reinforce the need for a greater investment in primary health care to reduce access barriers and cost burdens especially among the worse-offs. Facility’s construction and renovation and increased supply of healthcare workers and medical commodities are potential initiatives to consider. Other initiatives may need a multi-sectoral collaboration.
Study on Life Model of MOV Based on Multiple Parameters and Surge History
Authors: Xiaofei RUAN , JIN Shaoyun , Weigang WEN , Weidong CHENG
Published: September 2021

With the advance of intelligent operation and maintenance in china railways, the requirement of condition monitoring and remaining life prediction for lightning protection equipment has become increasingly urgent. MOV(Metal Oxide Varistor) is the key component of railway surge protector, and it is necessary to study the description model of its degradation process. The output of the model that uses a single parameter to characterize degradation is more prone to contingency, and cannot truly and fully reflect the life state of the MOV. The degradation of MOV is a cumulative effect, and its life model should consider the surge history information. In view of the above problems, a prediction model of the residual life value of MOV is given by combining various degradation related parameters and surge history. Firstly, nine degradation related parameters are fused to construct degradation core. Then, the degradation core and surge history are fused through Markov chain to build a life model of MOV. Then, the model is calibrated with experimental data. Finally, the model is validated and analyzed by experiments. The model can describe the degradation process of MOV more comprehensively and accurately, and can predict the residual life value at the same time, and it has potential application in the life assessment of surge protective devices.
Personality Matters: Exploring the Relationship between Personality and Stress Physiology in Captive African Lions
Authors: Vaz Janice , Bartley Alana , Hunt John
Published: September 2021

Background: Considering animals as individuals and not as species is becoming increasingly essential to animal welfare management. Recent studies on big cat personalities and coping strategies suggest personality can help big cats cope in their surroundings. Yet, a large portion of the published literature focuses on understanding either the personality or stress physiology of big cats in isolation. Our research shows how integrating an improved understanding of the personality of big cats with stress physiology may enhance welfare, especially endangered species like African lions. By using a wild cat personality checklist, this study compared African lion personality with its faecal stress glucocorticoids non-invasively. Results: We identified three personality types for individual African lions (Dominance, Agreeableness and Neuroticism) and examined whether these dimensions varied with stress cortisol levels. When controlling for differences in age across lions, we found a strong negative correlation between Agreeableness in lions and their glucocorticoid levels. This suggests that the personality of a lion may help it cope with its surroundings. Conclusions: Our findings can assist with the better management of big cats and it is proposed that ex-situ managers of zoos and rescue centres incorporate the personality data of their animals into the Zoological Information Management Software (ZIMS). This data can be accessed globally and can be useful for caretakers managing their animals according to their needs while undergoing veterinary procedures or in reintroduction programs. Thus, by improving individual welfare, we can improve overall welfare of big cats.
Assessment of Plasmodium Falciparum Antimalarial Drug Resistance Markers in pfcrt and pfmdr1 Genes in Isolates from Honduras and Nicaragua, 2018-2021
Authors: Fontecha Gustavo Adolfo , Pinto Alejandra , Archaga Osman , Betancourth Sergio , Escober Lenin , Henríquez Jessica , Valdivia Hugo O , Montoya Alberto , Mejía Rosa Elena
Published: September 2021

Background: Central America and the island of Hispaniola have set out to eliminate malaria by 2030. However, since 2014 a notable upturn in the number of cases has been reported in La Mosquitia region shared by Nicaragua and Honduras. In addition, the proportion of Plasmodium falciparum malaria cases has increased significantly relative to vivax malaria. Chloroquine continues to be the first line drug to treat uncomplicated malaria in the region. The objective of this study was to evaluate the emergence of chloroquine resistant strains using a genetic approach. Methods: 205 blood samples from patients infected with P. falciparum between 2018 and 2021 were analyzed. The pfcrt gene fragment encompassing codons 72-76 was analyzed. Likewise, three fragments of the pfmdr1 gene were analyzed in 51 samples by nested PCR and sequencing. Results: All samples revealed the CVMNK wild phenotype for the pfcrt gene and the N86, Y184F, S1034C, N1042D, D1246 phenotype for the pfmdr1 gene. Conclusions: The increase in falciparum malaria cases in Nicaragua and Honduras cannot be attributed to the emergence of chloroquine-resistant mutants. Other possibilities should be investigated further. This is the first study to report the genotype of pfmdr1 for five loci of interest in Central America.
WITHDRAWN: Modeling Post-harvest Quality by StanSAT, Applied to Cucumis Sativus L.
Authors: Cheng Chen , Xu Xinxing , Dong Chaoyang , Gong Zhihong , Barcena J. Fernando Bienvenido
Published: September 2021

Crop post-harvest quality model is designed to dynamically and accurately simulate the quality change process. In this study, the relationship between morphological indices and fruit quality (external quality and internal quality) were quantitatively simulated, and the post-harvest quality and quality evaluation value simulation model were established for the first time with standardized stress accumulated temperature (\({\text{S}\text{t}\text{a}\text{n}}_{\text{S}\text{A}\text{T}}\)). The results showed: 1) There were significant linear relationships between the fresh weight and the volume, the darker value and the color value, the tan H and the color value, and the water content and the soluble solid content. There was a significant quadratic relationship between fruit density and fruit shape index. There was a significant logarithmic relationship between the tan H and the darker value. 2) The quality indices, including quality evaluation value, darkness value, color value, darker value, shape index, tan H and density, showed a linear change trend with \({\text{S}\text{t}\text{a}\text{n}}_{\text{S}\text{A}\text{T}}\). The soluble solid content showed a quadratic function variation trend with \({\text{S}\text{t}\text{a}\text{n}}_{\text{S}\text{A}\text{T}}\). 3) For each quality index, normalized root mean square error (NRMSE) of each quality index and its evaluation simulation model based on \({\text{S}\text{t}\text{a}\text{n}}_{\text{S}\text{A}\text{T}}\) were from 1.58 % to 17.85 %, which showed the post-harvest quality index and quality evaluation simulation have high accuracy. Generally, the model could systematically and quantitatively express the dynamic process of post-harvest quality of cucumber.
Anisotropic, Biomorphic Cellular Si3N4 Ceramics with Directional Well-aligned Nanowhisker Arrays Based on Wood-Mimetic Architectures
Authors: Xu Song-Song , Zhou Xiao-Nan , Zhi Qiang , Gao Jun-Jie , Hao Liu-Cheng , Shi Zhong-Qi , Wang Bo , Yang Jian-Feng , Ishizaki Kozo
Published: September 2021

Inspired by the transport behavior of water and ions through the aligned channels in trees, we demonstrate a facile, scalable approach for constructing biomorphic cellular Si3N4 ceramic frameworks with well-aligned nanowhisker arrays on the surface of directionally aligned microchannel alignments. Through a facile Y(NO3)3 solution infiltration into wood-derived carbon preforms and subsequent heat treatment, we can faultlessly duplicate the anisotropic wood architectures into free-standing bulk porous Si3N4 ceramics. Firstly, α-Si3N4 microchannels were synthesized via carbothermal reduction nitridation. And then, homogeneous distributed Y-Si-O-N liquid phase on the walls of microchannel facilitated the anisotropic β-Si3N4 growth to form nanowhisker arrays. The dense aligned microchannels with low-tortuosity enable excellent load carrying capacity and thermal conduction through the entire materials. As a result, the porous Si3N4 ceramics exhibited an excellent thermal conductivity (TC, kR≈6.26 W·m− 1·K− 1), a superior flexural strength (σL ≈ 29.4 MPa), and a relative high anisotropic ratio of TC (kR/kL = ~ 4.1). The orientation dependence of the microstructure-property relations may offer a promising perspective for the fabrication of multifunctional ceramics.
Metastatic Malignant Gastric Glomus Tumour: Multidisciplinary Diagnosis & Treatment of a Rare Clinical Entity
Authors: Francheville Jordan W. , Arnason Thomas , Carter Michael D. , Khodadad Kian , Giacomantonio Carman , Williams Geoff
Published: September 2021

Glomus tumours are uncommon neoplasms that are usually benign, solitary and most often found in the skin and soft tissue of distal extremities. Primary gastric glomus tumors are rare, but well described. Fewer than 15 cases of gastric glomus tumour have been reported to have malignant behaviour with distant metastases. Although surgical resection is effective if feasible, recurrence can occur and there is a paucity of evidence on medical treatment options. Here we present the case of a 69-year-old male with a gastric glomus tumour with metastases to abdominal viscera requiring multidisciplinary care for diagnosis, surgical resection, and multiple lines of systemic/radiation therapy guided by available evidence. Genomic analysis revealed a NOTCH2 rearrangement, described in only two prior works and highlighting future possibilities for targeted therapy.
Impact of end-of-life respiratory modalities on quality of dying and death and symptom relief in patients with interstitial lung disease: a multicenter descriptive cross-sectional study
Authors: Koyauchi Takafumi , Suzuki Yuzo , Sato Kazuki , Hozumi Hironao , Karayama Masato , Furuhashi Kazuki , Fujisawa Tomoyuki , Enomoto Noriyuki , Nakamura Yutaro , Inui Naoki , Yokomura Koshi , Imokawa Shiro , Nakamura Hidenori , Morita Tatsuya , Suda Takafumi
Published: September 2021

Background: Respiratory modalities that applied at end of life may affect burden of distressing symptoms and quality of dying and death (QODD) among patients with end-stage interstitial lung disease (ILD); however, there have been few studies into respiratory modalities applied to these patients near death. We hypothesized that high-flow nasal cannula (HFNC) may contribute to improved QODD and symptom relief in patients with end-stage ILD.Objectives: This multicenter study examined the proportion of end-of-life respiratory modalities in a real-world setting and explored its impact on QODD and symptom relief among patients dying with ILD.Methods: Consecutive patients with ILD who died in four participating institutions in Japan from 2015 to 2019 were identified and divided into four groups according to end-of-life respiratory modality: conventional oxygen therapy (COT), HFNC, non-invasive ventilation (NIV), and invasive mechanical ventilation (IMV). In addition, a mail survey was performed to quantify the QODD and symptom relief at their end of life from a bereaved family’s perspective. QODD and symptom relief were quantified using the Good Death Inventory (GDI) for patients with a completed bereavement survey. The impact of end-of-life respiratory modalities on QODD and symptom relief was measured by multivariable linear regression using COT as a reference.Results: Among 177 patients analyzed for end-of-life respiratory modalities, 80 had a completed bereavement survey. The most common end-of-life respiratory modality was HFNC (n=76, 42.9%), followed by COT (n=62, 35.0%), NIV (n=27, 15.3%), and IMV (n=12, 6.8%). Regarding the place of death, 98.7% of patients treated with HFNC died outside the intensive care unit. Multivariable regression analyses revealed patients treated with HFNC had a higher GDI score for QODD [partial regression coefficient (B)=0.46, 95% CI: 0.07–0.86] and domain score related to symptom relief (B=1.37, 95% CI: 0.54–2.20) than those treated with COT. Conclusion: HFNC was commonly used in patients with end-stage ILD in real-world setting and was associated with higher QODD and better symptom relief. HNFC may contribute to improved QODD and symptom relief in these patients.
Phenotypic and expression QTL integration allows the refinement of loci associated with pig carcass and meat quality traits
Authors: Hérault Frédéric , Vincent Annie , Randriamanantena Ando Yoanne , Damon Marie , Cherel Pierre , Roy Pascale Le
Published: September 2021

Background: Many quantitative trait loci (QTLs) affecting pig meat and carcass quality traits have been reported. However, in most cases, the length of these phenotypic QTLs (pQTLs) is large. Hence, the identification of candidate genes and causative polymorphisms hidden behind those pQTLs remains a difficult task. Combining gene expression, phenotype and genotype data in an integrative genomics approach may help to identify regulatory networks and pathways underlying such complex traits. In the present study, we used genome-wide association study (GWAS) and linkage disequilibrium linkage analysis (LDLA) approaches to identify longissimus muscle (LM) and semimembranosus muscle (SM) expression QTLs (eQTLs). The locations of these eQTLs were compared to those of pQTLs previously mapped in the same population of commercial-type pigs. Colocalized eQTLs/pQTLs could help to identify candidate genes and pathways involved in pig carcass and meat quality trait determination. Results: Both approaches led us to identify 1,253 and 1,109 genome-wide significant eQTLs for LM and SM, respectively. We identified only one common eQTL between the two muscles and a few significant common eQTLs between methodologies : 16 in SM and 1 in LM. A total of 192 overlapping locations were identified between eQTLs and pQTLs. Colocalization highlighted some genes involved in muscle development, adipogenic processes or ion calcium homeostasis. These eQTLs allowed us to refine previously identified pQTLs related to carcass and meat quality traits. However, in most cases, the refined loci were still large and contained several coding and noncoding genes. Conclusions: Our results shed light on the muscle-specific genetic control governing mRNA expression and hence controlling the development of pig carcass and meat quality traits. Moreover, colocations between eQTLs and pQTLs implicated genes potentially involved in muscle development, adipogenic processes or ion calcium homeostasis in the pathways governing these traits. Finally, our results allowed us to refine QTLs controlling meat quality traits and to highlight the possible involvement of long noncoding RNAs in the architecture of regulatory networks governing complex traits such as pig carcass and meat quality traits.
Assessing the potential repercussions of the COVID-19 pandemic on global SDG attainment
Authors: Doi Hideyuki , Osawa Takeshi , Tsutsumida Narumasa
Published: September 2021

The coronavirus disease (COVID-19) pandemic has led to a worldwide lockdown, and this restriction on human movements and activities has significantly affected society and the environment. This study examined the consequences of global lockdown for human movement and nitrogen dioxide (NO2) emissions using an air pollution index and dataset and satellite image analyses. We also evaluated the immediate (during lockdown) and persistent (after lockdown) effects of lockdown on achieving the Sustainable Development Goals (SDGs). Our analysis revealed a drastic reduction in human movement and NO2 emissions and showed that many SDGs were influenced both immediately and persistently due to the global lockdown. We observed immediate negative impacts on four goals and positive impacts on five goals, especially those concerning economic issues and ecosystem conservation, respectively. The persistent effects of lockdown were likely to be predominantly reversed from their immediate impacts due to economic recovery. The global lockdown has influenced the global community’s ability to meet the SDGs, and our analysis provides powerful insights into the status of the internationally agreed-upon SDGs both during and after the COVID-19-induced global lockdown.
Determinants of Government Expenditure In Southwest Nigeria
Authors: Ilugbusi Bamidele Segun , Ogundipe Adebayo Tunbosun , Ojo Oluwasegun David
Published: September 2021

This study examined the determinants of government expenditure in Southwest Nigeria. The study adopted ex-post facto research design and it covered 10 years, spanning from 2010 to 2019. The panel data used was sourced from the CBN statistical bulletin (2019) and the annual budget of each of the sampled states. Panel data estimation techniques were used and based on the most consistent and efficient estimation, it was discovered that internally generated revenue exerts a positive significant effect on both capital and recurrent expenditure to the tune of1.315 (p=0.000 < 0.05) and 0.670(p=0.001 < 0.05) respectively. It was equally discovered that statutory allocation exerts a positive but insignificant effect on both capital and recurrent expenditure for the period covered to the tune of 0.34 (p=0.236 > 0.05) 0.389 (p=0.065 > 0.05) respectively. Also, it was discovered that domestic debt exerts a negative insignificant effect on capital expenditure to the tune of -0.061 (p=0.733 > 0.05). Finally, domestic debt has a positive but insignificant effect on recurrent expenditure to the tune of 0.109 (p=0.352 > 0.05). It was established that internally generated revenue, statutory allocation and domestic debt are the determinant factors of public expenditure across all the states in the Southwest region of Nigeria. Thus, it was recommended that available revenue should be judiciously utilized on the pressing needs of the state. While revenue is needed for the functionality of the government, state governments are urged to embrace more capital projects through which additional revenue might be generated.
Ovarian steroid cell tumors, not otherwise specified: Analysis of nine cases with a literature review
Authors: Lin Mengyan , Lu Lingjia , Xu Shuhang , Liang Yun , Cheng Xiaodong , Wang Fenfen
Published: September 2021

Objective
Ovarian steroid cell tumors (SCTs), not otherwise specified (NOS), are rare, with few large studies. The purpose of this study was to analyze the clinical features, prognosis, and treatment choices for SCT-NOS patients of different age groups.
Methods
This was a retrospective study. We identified nine SCT-NOS cases, confirmed by post-operative histopathological examination, and analyzed clinical features, surgical procedures, and follow up outcomes. We also reviewed cases reports of SCT-NOS.
Results
A total of nine cases were included. The age range was 9–68 years (mean, 41.89 ± 19.72 years). Clinical features included virilization, amenorrhea, abdominal pain, vaginal bleeding, isosexual precocious puberty, Cushing’s syndrome, and abnormal weight gain with elevated testosterone levels. The follow up interval ranged 5–53 months and no recurrence was observed.
Conclusion
Ovarian SCTs covered all age groups, with manifestations of androgen excess. Younger patients appeared to have a more favorable prognosis, which provided more opportunities for these patients to pursue treatment options that will preserve reproductive function.
Developmental exposure to the A6-pesticide causes changes in tyrosine hydroxylase gene expression, neurochemistry, and locomotor behavior in larval zebrafish
Authors: Ahmed NASRI , Pierre-André Lafon , Mezni Amine , Clair Philippe , Cubedo Nicolas , Mahmoudi Ezzeddine , Beyrem Hamouda , Rossel Mireille , Perrier Véronique
Published: September 2021

In recent years, the increase in the synthesis of biopesticides for alternative agricultural uses has necessitated the study of their impacts. Among these compounds, several of them are known to exert endocrine-disrupting effects causing deregulation of a variety of physiological functions affecting cell signaling pathways involved in neural cell differentiation leading to developmental neurotoxicity. In this current paper, we thus determined the impact of the biopesticide A6 on zebrafish larvae, which is structurally linked to estrogenic endocrine disruptors. The objective of this study was to define the toxicity of A6, the mechanisms responsible, and to evaluate its effects on the locomotor activity at nanomolar concentrations (0, 0.5, 5, and 50 nM). We show through its blue fluorescence properties that A6 accumulates in different parts of the body as intestine, adipose tissue, muscle, yolk sac and head. We display also that A6 disrupt the development and affects the function of the central nervous system, especially the expression of tyrosine hydroxylase (TH) in dopaminergic neurons. We studied whether A6 disturbs the target genes expression and recorded that it downregulated genes embroiled in TH expression, suggesting that A6’s neurotoxic effect may be the result of its binding propinquity to the estrogen receptor.
Employee Monetary Compensation and Employee Job Satisfaction
Authors: Watkins Randolph , Fusch Patricia
Published: September 2021

It is known employee job satisfaction is related to employee motivation, performance, retention, and other factors which are beneficial to the employee and the employer. In recent decades, some have used the work of Self-Determination Theory to claim pay is irrelevant and promote the idea it is an employee’s commitment, attitude, and the programs the employer offers the employee that are important to employee satisfaction, motivation, performance, morale, and retention. However, the work of Self-Determination Theory has neither stated nor confirmed this concept. In a study considering if and to what extent a relationship exists between employee rate of monetary compensation and employee job satisfaction, it was found a statistically significant positive relationship exists between employee rate of monetary compensation and employee overall, extrinsic, and intrinsic job satisfaction. The sample consisted of N = 129 employees of Fortune 500 companies within the United States of America. Utilizing Spearman’s rank-order correlation employee overall job satisfaction resulted in 𝜌 = .290, employee extrinsic job satisfaction resulted in 𝜌 = .227, and employee intrinsic job satisfaction resulted in 𝜌 = .325 all demonstrating a positive relationship with employee rate of monetary compensation. This article discusses the current literature, results, and implications.
Nonlinearity Analysis of Quantum Capacitance and its Effect on Nano-Graphene Field Effect Transistor characteristics
Authors: MUNINDRA MUNINDRA , NAND DEVA
Published: September 2021

A simple, compact, and fundamental physics-based quasi-analytic model for Single layer graphene field effect transistors (GFETs) with large area graphene is presented in which the quantum mechanical density gradient method is utilised. The basic device physics of the two-dimensional (2D) graphene channel is studied analytically. This modeling leads to the precise drain current calculation of the GFETs. The drain current calculation for GFETs starts from charge carrier concentration, its density of states and quantum capacitance(QC). QC depends on the channel voltage as a function of gate to source voltage Vgs and drain to source voltage Vds primarily. The formulation of the drain current with velocity saturation has been done by the Monte Carlo simulation method. The performance of the analytical GFETs model is present the precise values of QC, its impact on drain current and transfer as well as output characteristics. The impact of QC at nanometer technology adds the nonlinearity to characteristics curves. The proposed method provides better results as compared with the previous analytical and simulated results.
On the tensile creep deformation behaviour of wrought single-phase γ-TiAl
Authors: Saha Mainak
Published: September 2021

Creep deformation behaviour in single phase γ-TiAl alloy has been an extensively studied topic since the late 1970s. A lot of literatures have reported creep behaviour of γ-TiAl alloys, manufactured using different processing techniques [1]–[7]. The present discussion revisits the original work on understanding the tensile creep deformation behaviour of wrought single-phase γ-TiAl alloy by Hayes et al. [8] and is aimed to develop an understanding of steady state creep, through strain vs strain rate and strain vs ln(strain rate) plots. Besides, it also attempts to study the variation of stress exponent with temperature between 760–900⁰C and also, to determine activation energies using the two most common approaches, namely: Zener-Hollomon (Z-H) [9] and Sherby-Dorn (S-D, temperature compensated time approach) [10] for stress levels of 69.4 and 103.4 MPa between 760–900⁰C.
Research progress of sustainable brownfield redevelopment planning and design: Based on visual bibliometric analysis
Authors: MASRABAYE Francis , Zheng Bohong , Guiradoumngue Gerald Madjissembaye , Zheng Jian
Published: September 2021

Environmental and urban sciences have shown that brownfield problems have a significant impact on human behavior and its environment. Understanding the sustainable planning and redevelopment of brownfields can therefore help governments and financial partners to consider sustainable urban policies as a key priority. This study presents a bibliometric analysis of research publications on the sustainable redevelopment of brownfields through the Scopus database since 1990. The redevelopment of brownfields having an essential role in urban sustainability, so research trends on sustainable redevelopment brownfields in previous literature are revealed. To our knowledge, the bibliometric analysis of the term sustainable redevelopment of brownfields is not yet an accentuated field of research. To do this, this study aims to fill this gap by offering a broad overview of the bibliometric analysis of the literature relating to this term. Brownfield and contaminated land are used as a keyword in the article titles taken from the Scopus database on September 07, 2021. A total of 7197 scientific articles (Scopus) were reviewed to show how the research on " brownfields or contaminated land” has emerged and developed. Social media analysis (VOSviewer) was used for data visualization and Harzing's Publish or Perish is used for metrics and citation analysis. The results showed an increase in the growth rate of the literature on sustainable brownfield redevelopment since 1990, particularly from 2011 to 2020. Research related to the sustainable redevelopment of brownfields has involved various authors and is published in various languages. There are 160 authors from 126 countries and 160 institutions. The China is the largest contributor to this study, followed by the United States and United Kingdom. The Chemosphere Journal has published the most articles on the sustainable redevelopment of brownfields. Although our results also indicate that studies on the sustainable redevelopment of brownfields are mainly carried out in the field of environmental sciences. Some avenues for future research have been analyzed in three directions so that sustainable development can easily be integrated into a brownfield redevelopment project.
Nintedanib reduces corticosteroid resistance pulmonary fibrosis induced by bleomycin in mice by increasing the expression of β3 & β6 integrins
Authors: alghamdi doha omar , kawy Hala S Abdel , Damanhouri Zhair A
Published: September 2021

Background: Corticosteroid resistance pulmonary fibrosis is a major health problem. This study aimed to determine the effectiveness of nintedanib on corticosteroid resistance pulmonary fibrosis induced by bleomycin in mice. Methods: The mice were divided into five groups 12 mice each. control group, BLM group received single dose of bleomycin (BLM), BLM+MP group received BLM and methylprednisolone (MP), BLM+NIN group received BLM and nintedanib(NIN) and BLM + NIN + MP group. The lung tissues were obtained for biochemical analysis, gene expression and histopathological examination on day 7 and day 28. Results: after 7 days, both NIN groups showed a significant decrease in the levels of interleukin-2, interleukin-4, interferon-gamma, lung tumor necrosis factor-alpha, Malondialdehyde and lung water content with a significant increase in the Glutathione level in lung tissues compared to MP group. After 28 days, both NIN groups showed a significant reduction in hydroxyproline, and Trans-forming Growth Factor beta lung tissues contents compared to MP group, and they showed a positive effect on the expression of β 3 &β6 integrins compared to the negative effect of MP group. Histopathologically, both NIN groups showed significant improvement compared to MP group by H&E and Masson’s trichrome stains. Immunohistochemical staining revealed negative BCL-2 expression in the cytoplasm of bronchiolar epithelium in both NIN groups after 7 and 28 days of treatment. Lung tissue morphometric studies showed significant improvement of pathological changes induced by BLM in both NIN groups. Conclusion: Altogether, our data indicates that nintedanib overcame corticosteroid resistance pulmonary fibrosis induced by bleomycin.
DESAFIOS NA ATENÇÃO PRIMÁRIA E OS PERCALÇOS NA BUSCA PELA INOVAÇÃO
Authors: Abreu Arlete , Damasceno Souza Pedro
Published: September 2021

O objetivo desta pesquisa foi identificar os principais desafios (drivers) que gestores de Unidades Básicas de Atenção Primária enfrentam e se as estratégias delimitadas para lidar com tais percalços constituem-se em inovação. Para este processo, foi utilizado o modelo Neo-Schumpteriano de inovação em serviços públicos como lente de análise. Foram realizadas sete entrevistas com gestores das unidades de saúde de um município do oeste mineiro. Os resultados apontam seis desafios e algumas estratégias usadas para lidar com os mesmos. No entanto, nem a resposta aos desafios e nem algumas ações isoladas diferenciadas identificadas podem ser compreendidas como inovação. Ressalta-se a dinâmica entre os desafios e o peso do vetor político no processo.
ELABORAÇÃO DE UM MATERIAL EDUCATIVO PARA PROFISSIONAIS DA ATENÇÃO BÁSICA SOBRE PROMOÇÃO DA SAÚDE DO IDOSO
Authors: Braatz Petermann Xavéle , Emanuel Weiss Pinheiro Guilherme , Kocourek Sheila
Published: September 2021

Objetivo: Relatar a experiência do processo de elaboração de um material educativo intitulado “Promoção da Saúde de Pessoa Idosa: Guia de orientação para o profissional da atenção básica”. Metodologia: Embasou-se no estudo de caso, com a participação de diferentes atores. Os dados foram coletados por meio de grupo focal e entrevistas individuais. Referencial teórico: O envelhecimento populacional ocorre de modo acelerado no Brasil, caracterizado por uma transição epidemiológica, com destaque para as doenças crônicas. A pandemia de COVID-19 deixou esse contexto ainda mais complexo, sendo que, os idosos foram apontados como os mais vulneráveis, exigindo ações de promoção da saúde na atenção básica. Resultados: A partir da análise temática – acesso, determinantes da saúde, rede de apoio familiar, construção de saberes e cuidado integral - que denotaram a percepção dos profissionais da atenção básica sobre a promoção da saúde do idoso foi proposta a confecção do material educativo. Conclusões: Espera-se disseminar as potencialidades da construção coletiva de um material educativo, considerando diferentes perspectivas sobre a promoção da saúde do idoso.
MARKETING SOCIAL PARA DOAÇÃO DE SANGUE EM TEMPOS DE PANDEMIA DE COVID-19 NA CIDADE DE MACEIÓ/AL
Authors: Lourenço dos Santos José Ilson , Farias Gomes Ednaldo , Da Silva Anjo José Edemir
Published: September 2021

O trabalho objetiva compreender a captação e fidelização de potenciais doadores de sangue do Hemocentro de Alagoas (Hemoal), Unidade Maceió, durante a pandemia da Covid-19. A pesquisa aponta para a necessidade da utilização do Marketing Social voltado para doação de sangue, uma vez que o mesmo pode colaborar para aumentar significantemente os níveis de doações diante da pouca cultura de doação de sangue no país e da alarmante escassez de estoques de bolsas de sangue e demais hemocomponentes. Dado problema de pesquisa pautado, o trabalho resulta de um estudo de caso com caráter exploratório-descritivo de abordagem qualitativa. Identificou-se, mediante análise dos materiais acessados, que, embora o Hemoal apresente algumas estratégias a fim de potencializar a prestação de seus serviços, as mesmas ocorrem de forma pontual e desarticuladas. Considerando este entendimento, no que tange à promoção e adesão de uma cultura de doação de sangue no Estado de Alagoas, evidenciamos ao Hemoal a atenção para formulações de estratégias que tenham como base o Marketing Social.
EFEITOS INDIRETOS DA COVID-19: MUDANÇAS NAS TAXAS DE INTERNAÇÃO EM MINAS GERAIS E SÃO PAULO
Authors: Costa Bomfim Wanderson , Castro Santos Camargos Mirela
Published: September 2021

Objetivo:Estimar as taxas de internação por doenças do aparelho circulatório durante o ano de 2020, comparando com a tendência histórica de 2011 a 2019, para o estado de Minas Gerais e São Paulo, para a população masculina e feminina com 60 anos ou mais. Método: Estudo transversal e ecológico. Utilizaram-se dados das internações por doenças do aparelho circulatório. As análises se deram por taxas de internação brutas padronizadas, mudanças percentuais anuais e regressão linear simples. Resultados: Foram observadas importantes reduções das taxas de internação do grupo de causa em análise, bem superiores ao que vinha sendo observado. A tendência das taxas de internação por doenças do aparelho circulatório entre 2011 e 2019, em especial para indivíduos com 60 anos ou mais, já vinham apresentando tendência de queda e foi ainda mais intensificada no ano de 2020. Conclusão: As determinações de isolamento social e a capacidade técnica das instituições de saúde voltada para as demandas da pandemia tiveram um papel fundamental na redução das internações por doenças do aparelho circulatório, trazendo questionamentos sobre os impactos dessas postergações para o sistema e os indivíduos.
A sportoláshoz kapcsolódó tudatos vízfogyasztás hatásai
Authors: Buti Nikolett , H. Ekler Judit
Published: September 2021

Bevezetés és célkitűzés A gyermekek kognitv funkcióit enyhe fokú kiszáradás már megváltoztatja. Ezért a kognitv fejlődésben is fontos szerepet tölt be a megfelelő folyadékpótlás. Kutatásunkban arra voltunk kíváncsiak, hogy az általunk vizsgált 12. évfolyamos diákok (N=37) vízháztartása összefüggésbe hozható-e kognitv képességeikkel, valamint izomerejükkel. Vizsgálatunkban a jól (2. cs.) és kevésbé jól hidratált (1. cs.) tanulói csoportokat hasonlítotuk össze a Kognitv Profl Teszt, valamint a NETFIT erőprofl adatai alapján. Eredmények és következtetés A 2. csoport tanulóinak az InBody ftségi pont értékei szignifkánsan jobbak voltak, mint az 1. csoport tanulóié. Azonban a két csoport NETFIT erőprofl eredményei közöt nincs szignifkáns különbség. Így azt, hogy a tanulók jobb vízháztartása pozitvan befolyásolja az izomerejüket, nem tudtuk igazolni. A Kognitv Profl Teszt pontszámai összesítve nem mutatak különbséget a két csoport közöt, azonban a „Mennyiségek” feladatban a 2. csoport szignifkánsan jobb eredményt ért el, míg a „Számolási műveletek” tesztben tendenciához közeli értékeket kaptunk, a 2. csoport javára. Tehát a pozitv vízháztartás kognitv képességekre gyakorolt hatása részben igazolható.
Sportolók megküzdési stratégiái bokasérülést követően
Authors: Németh Zsolt , Mittly Veronika , Berényi Károly , Mintál Tibor
Published: September 2021

A bokasérülések ellátása részletesen kidolgozot protokollokkal történik, azonban ez nem terjed ki a sérült pszichés gondozására. Előzetes irodalmi adatok azonban alátámasztják ennek szükségességét. Kimutaták, hogy a pszichológiai intervenció a rehabilitáció során számos előnnyel jár a felépülés alat (Armatas et al., 2007). A kutatásunk célja, hogy az eddigi irodalmi adatokat alátámasszuk és felhívjuk a sportorvosok és edzők fgyelmét a komplex szemléletmód fontosságára, illetve hogy segítsük a sportolókat a sérülés pszichés feldolgozásában. A bokasérülések pszichés következményeinek megítélése céljából 2014 októbere és decembere közöt 96 sportolóval töltetünk ki egy általunk összeállítot, 28 kérdésből álló kérdőívet. Közülük 42 fő papír alapon, míg 54 sportoló online válaszolt a kérdésekre. A válaszokat SPSS program segítségével értékeltük ki. Kimutatuk, hogy összefüggés van a belső motváció, az újrasérüléstől való félelem, sport esetleges abbahagyása, a rehabilitációs munka, a társas támogatás, a sportolás szintje és a megküzdési stratégiák közöt. Ezenfelül eredményeink alátámasztják, hogy a sérülés utólagos megítélését befolyásolják a sérülést követő percek, hetek történései. Eredményeink igazolják a korábbi következtetésünket, miszerint a sportolók bokasérülése multdiszciplináris ellátást igényel. Megerősítést nyert, hogy a bokasérülést elszenvedet sportemberek igénylik a pszichés vezetést és társas támogatást a sérülést követő időszakban. A sporthoz való visszatéréshez a gyógytorna és fzikoterápia mellet szükség van pszichés felkészítésre is.
Immunrendszer-erősítés gyógynövényekkel időskorban is
Authors: Pászk Norbert
Published: September 2021

A ftoterápia, azaz a gyógynövénygyógyászat számos olyan hazai és külföldi gyógynövényt ismer és használ, amelyek segíthetk a szervezet védekezőrendszerének, azaz az immunrendszernek a normál működését, és erősíthetk azt. Azonban nemcsak a hétköznapi értelemben vet gyógynövények rendelkeznek ilyen hatással. A különböző tápláléknövények, méhészet termékek, illóolajok, gyógygombák és fűszernövények közöt is szép számmal találhatunk ilyen célra használható fajokat. Érdemes tudni azt is, hogy nem feltétlenül szükséges külföldi növényeket kipróbálnunk, ugyanis Magyarország rendkívül jó természet adottságai révén bőségesen ellát minket ezekkel a gyógyhatású növényekkel és egyéb gyógyászat termékekkel, melyek kiegészítő terápiaként időskorban is hatalmas segítséget nyújthatnak.