bluuebunny/crossref_metadata_2025 huggingface dataset:
A specific combination of laboratory data is associated with overweight lungs in patients with COVID-19 pneumonia at hospital admission: secondary cross-sectional analysis of a randomized clinical trial
Authors: Silva Pedro L. , Cruz Fernanda F. , Martins Camila M. , Herrmann Jacob , Gerard Sarah E. , Xin Yi , Cereda Maurizio , Ball Lorenzo , Pelosi Paolo , Rocco Patricia R. M.
Published: May 2023

Background

Lung weight may be measured with quantitative chest computed tomography (CT) in patients with COVID-19 to characterize the severity of pulmonary edema and assess prognosis. However, this quantitative analysis is often not accessible, which led to the hypothesis that specific laboratory data may help identify overweight lungs.

Methods

This cross-sectional study was a secondary analysis of data from SARITA2, a randomized clinical trial comparing nitazoxanide and placebo in patients with COVID-19 pneumonia. Adult patients (≥18 years) requiring supplemental oxygen due to COVID-19 pneumonia were enrolled between April 20 and October 15, 2020, in 19 hospitals in Brazil. The weight of the lungs as well as laboratory data [hemoglobin, leukocytes, neutrophils, lymphocytes, C-reactive protein, D-dimer, lactate dehydrogenase (LDH), and ferritin] and 47 additional specific blood biomarkers were assessed.

Results

Ninety-three patients were included in the study: 46 patients presented with underweight lungs (defined by ≤0% of excess lung weight) and 47 patients presented with overweight lungs (>0% of excess lung weight). Leukocytes, neutrophils, D-dimer, and LDH were higher in patients with overweight lungs. Among the 47 blood biomarkers investigated, interferon alpha 2 protein was higher and leukocyte inhibitory factor was lower in patients with overweight lungs. According to CombiROC analysis, the combinations of D-dimer/LDH/leukocytes, D-dimer/LDH/neutrophils, and D-dimer/LDH/leukocytes/neutrophils achieved the highest area under the curve with the best accuracy to detect overweight lungs.

Conclusion

The combinations of these specific laboratory data: D-dimer/LDH/leukocytes or D-dimer/LDH/neutrophils or D-dimer/LDH/leukocytes/neutrophils were the best predictors of overweight lungs in patients with COVID-19 pneumonia at hospital admission.

Clinical trial registration

Brazilian Registry of Clinical Trials (REBEC) number RBR-88bs9x and ClinicalTrials.gov number NCT04561219.
Case report: Ultrasound biomicroscopy as a guide for the selection of injection sites for dexamethasone intravitreal implant (Ozurdex) for peripheral granulomatous ocular toxocariasis in children
Authors: Zhang Xin , Hou Xinzhu , Zhang Yan , Liu Jingjie , Zhang Zhiyong
Published: May 2023

Purpose

This article aims to report a case of successful treatment of peripheral granulomatous ocular toxocariasis (OT) in an 8-year-old patient using intravitreal injection of dexamethasone (DEX) implant (Ozurdex) under ultrasound biomicroscopy (UBM) guidance.

Case presentation

A previously healthy 8-year-old boy with a history of long-term close contact with dogs complained of blurring of vision in the right eye for a year. Ophthalmic examination of his right eye showed chronic uveitis. Notably, UBM examination identified granulomas and peripheral vitreous strand in the ciliary body from 3 to 8 o'clock positions. Enzyme-linked immunosorbent assay (ELISA) results of the intraocular fluid (IF) and serum showed increased anti-Toxocara immunoglobulin G (IgG) levels, leading to a diagnosis of peripheral granulomatous OT in the right eye. Intraocular surgery was not indicated in this case. The treatment goal was to alleviate uveitis, improve visual acuity, and prevent complications. He was treated with an intravitreal injection of DEX implant, administered as a single dose every three months, total two doses, combined with albendazole, an oral anthelmintic. Under preoperative UBM guidance, two injections were performed at the 12 and 10 o'clock positions in the pars plana where there were no granulomas and peripheral vitreous strand, successfully preventing complications associated with intravitreal injection. After two injections, the patient's right eye vision improved significantly, with the best-corrected visual acuity (BCVA) increasing from 20/400 to 20/50. Vitreous opacity and retinal edema were reduced, preretinal proliferative membrane was stabilized, and no adverse events occurred.

Conclusion

UBM can accurately determine the location and extent of peripheral granulomas in OT patients, facilitating the avoidance of granulomas during intravitreal injection and preventing complications associated with intravitreal injection. Under the close follow-up and strict adherence to indications, preoperative UBM-guided intravitreal injections of DEX implant treatment for pediatric peripheral granulomatous OT are safe and effective, providing a new therapeutic option for pediatric peripheral granulomatous OT.
Arbuscular mycorrhizae influence raspberry growth and soil fertility under conventional and organic fertilization
Authors: Lu Qianwen , Bunn Rebecca , Whitney Erika , Feng Yuanyuan , DeVetter Lisa Wasko , Tao Haiying
Published: May 2023

Introduction

Introducing beneficial soil biota such as arbuscular mycorrhizal fungi (AMF) to agricultural systems may improve plant performance and soil fertility. However, whether bioinocula species composition affects plant growth and soil fertility, and whether fertilizer source influences AMF colonization have not been well characterized. The objectives of this research were to: (1) assess if AMF bioinocula of different species compositions improve raspberry (Rubus idaeus L.) performance and characteristics of soil fertility and (2) evaluate the impact of fertilizer source on AMF colonization.

Methods

Five bioinocula with different AMF species compositions and three fertilizer sources were applied to tissue culture raspberry transplants in a randomized complete block design with eight replicates. Plants were grown in a greenhouse for 14 weeks and plant growth, tissue nutrient concentrations, soil fertility, and AMF root colonization were measured.

Results

Shoot K and Zn concentrations as well as soil pH and K concentration increased in the Commercial Mix 1 treatment (Glomus, Gigaspora, and Paraglomus AMF species) compared to the non-inoculated control. RFI (raspberry field bioinoculum; uncharacterized AMF and other microbiota) increased soil organic matter (SOM), estimated nitrogen release (ENR), and soil copper (Cu) concentration compared to the non-inoculated control. Furthermore, plants receiving the Mix 1 or RFI treatments, which include more AMF species, had greater AMF root colonization than the remaining treatments. Plants receiving organic fertilizer had significantly greater AMF colonization than conventionally fertilized plants.

Conclusion

Taken together, our data indicate that coupling organic fertilizers and bioinocula that include diverse AMF species may enhance raspberry growth and soil fertility.
Biodegradation of polyvinyl chloride by Citrobacter koseri isolated from superworms (Zophobas atratus larvae)
Authors: Nyamjav Indra , Jang Yejin , Lee Ye Eun , Lee Sukkyoo
Published: May 2023

Polyvinyl chloride (PVC) is one of the widely used plastic products worldwide, and its accumulation in the natural environment has become a major global issue with regard to the environment and biotic health. There is accordingly strong demand for the development of solutions and methods for environmental remediation. Degrading plastic waste using microorganisms is an effective and eco-friendly method. However, evidence of bacteria that afford efficient biodegradation of unplasticized, pure PVC film has yet to be reported. Therefore, the biodegradation of PVC becomes very important. Here, we present results on the physicochemical and structural studies of PVC by Citrobacter koseri (C. koseri) isolated from the gut of the superworm, Zophobas atratus (Z. atratus) larvae. We also studied the biodegradability of PVC by the gut microbiota compared with C. koseri. We analyzed the microbial degradation of the PVC surface using field emission scanning electron microscopy (FE-SEM) and energy-dispersive X-ray spectroscopy (EDS) and confirmed that the physical and chemical changes were caused by C. koseri and the gut microbiota. The chemical structural changes were further investigated using X-ray photoelectron spectroscopy (XPS) and Fourier-transform-infrared (FTIR) spectroscopy, and it was confirmed that the oxidation of the PVC surface proceeded with the formation of carbonyl groups (C = O), and hydroxyl groups (−OH) by C. koseri. Additionally, the gut microbiota composed of diverse microbial species showed equal oxidation of PVC compared to C. koseri. Further, we evaluated the capabilities of single bacterial isolate and gut microbiota for pure PVC film biodegradation. Our results verified that C. koseri and the culturable microbiota from the gut of superworms present similar potential to utilize pure PVC film as a carbon source. These findings provide a potential solution for the biodegradation of unplasticized PVC.
A bibliometric analysis of microbial forensics from 1984 to 2022: progress and research trends
Authors: Guo Xiangnan , Gu Liya , Luo Yue , Wang Shuangshuang , Luo Haibo , Song Feng
Published: May 2023

Microbial forensics is a rapidly evolving discipline that has gained significant momentum in recent years. The study evaluated relevant results over the last four decades from 1984 to 2022 all over the world, aiming to analyze the growing trends and research orientations of microbial forensics. Using “microbial forensics” as the search topic in the Web of Science Core Collection, the systematic retrieval identified 579 documents relevant to the field and draw many statistical tables and maps to make the retrieval results visible. According to further bibliometric analysis, there are an increasing number of publications related to microbial forensics from the overall trend, with the highest number of publications recorded in 2021. In terms of the total number of articles, the USA and China were both the leading contributors to the field among 40 countries. The field has developed rapidly in recent years based on the development of next-generation sequencing. Over the course of its development, there are rich keywords in the research of scholars, which focus on diversity and identification. Moreover, despite the early hot topic being PCR (the use of PCR to probe microorganisms), in recent years, the topics, markers, and the potential application of microorganisms in forensic practice have become hot, which also indicates the future research directions of microbial forensic.
Anesthetics inhibit phosphorylation of the ribosomal protein S6 in mouse cultured cortical cells and developing brain
Authors: Friese Matthew B. , Gujral Taranjit S. , Palanisamy Arvind , Hemmer Brittany , Culley Deborah J. , Crosby Gregory
Published: May 2023

Introduction

The development and maintenance of neural circuits is highly sensitive to neural activity. General anesthetics have profound effects on neural activity and, as such, there is concern that these agents may alter cellular integrity and interfere with brain wiring, such as when exposure occurs during the vulnerable period of brain development. Under those conditions, exposure to anesthetics in clinical use today causes changes in synaptic strength and number, widespread apoptosis, and long-lasting cognitive impairment in a variety of animal models. Remarkably, most anesthetics produce these effects despite having differing receptor mechanisms of action. We hypothesized that anesthetic agents mediate these effects by inducing a shared signaling pathway.

Methods

We exposed cultured cortical cells to propofol, etomidate, or dexmedetomidine and assessed the protein levels of dozens of signaling molecules and post-translational modifications using reverse phase protein arrays. To probe the role of neural activity, we performed separate control experiments to alter neural activity with non-anesthetics. Having identified anesthetic-induced changes in vitro, we investigated expression of the target proteins in the cortex of sevoflurane anesthetized postnatal day 7 mice by Western blotting.

Results

All the anesthetic agents tested in vitro reduced phosphorylation of the ribosomal protein S6, an important member of the mTOR signaling pathway. We found a comparable decrease in cortical S6 phosphorylation by Western blotting in sevoflurane anesthetized neonatal mice. Using a systems approach, we determined that propofol, etomidate, dexmedetomidine, and APV/TTX all similarly modulate a signaling module that includes pS6 and other cell mediators of the mTOR-signaling pathway.

Discussion

Reduction in S6 phosphorylation and subsequent suppression of the mTOR pathway may be a common and novel signaling event that mediates the impact of general anesthetics on neural circuit development.
Postnatal ethanol exposure impairs social behavior and operant extinction in the adult female mouse offspring
Authors: Bariselli Sebastiano , Reuveni Noa , Westcott Nina , Mateo Yolanda , Lovinger David M.
Published: May 2023

Fetal Alcohol Spectrum Disorder (FASD) comprises a group of neurodevelopmental deficits caused by alcohol exposure during pregnancy. Clinical studies suggest that while the male progeny experiences serious neurodevelopmental defects, female patients have more severe cognitive, social, and affective symptoms. Other than sex, dose, frequency, and timing of exposure determine the neurobehavioral outcomes in young and adult progeny. In this regard, human studies indicate that some individuals relapse during late-term gestational periods. In mice, this interval corresponds to the first 10 days after birth (postnatal, P0-P10). In our model of postnatal ethanol exposure (PEEP0-P10), we tested whether adult female and male offspring show deficits in sociability, anxiety-like, reward consumption, and action-outcome associations. We report that female PEEP0-P10 offspring have mild social impairments and altered extinction of operant responding in the absence of anxiety-like traits and reward consumption defects. None of these deficits were detected in the male PEEP0-P10 offspring. Our data provide novel information on sex-specific neurobehavioral outcomes of postnatal ethanol exposure in female adult offspring.
Recent research progress on the synthesis and biological effects of selenium nanoparticles
Authors: Zhang Ting , Qi Meng , Wu Qian , Xiang Peng , Tang Dejian , Li Qiang
Published: May 2023

Selenium is an essential trace element for the human body, with the chemical and physical characteristics of both metals and nonmetals. Selenium has bioactivities related to the immune system, antioxidation, anti-virus, and anti-cancer. At the same time, it also plays a role in reducing and alleviating the toxicity of heavy metals. Compared with inorganic selenium, organic selenium is less toxic and has greater bioavailability. Selenium nanoparticles (SeNPs) have the advantages of high absorption rate, high biological activity, and low toxicity, and can be directly absorbed by the human body and converted to organic selenium. Selenium nanoparticles have gradually replaced the traditional selenium supplement and has broad prospects in the food and medical industries. In this paper, the chemical, physical, and biological methods for the synthesis of selenium nanoparticles are reviewed, and the microbial synthesis methods of selenium nanoparticles, the effects of selenium nanoparticles on crop growth, and the antibacterial, antioxidant, anticancer, and anti-tumor effects of selenium nanoparticles are also systematically summarized. In addition, we evaluate the application of selenium nanoparticles in selenium nutrition enhancement, providing support for the application of selenium nanoparticles in animals, plants, and humans.
Early-onset locally advanced rectal cancer characteristics, a practical nomogram and risk stratification system: a population-based study
Authors: Su Yang , Yang Da Shuai , Li Yan qi , Qin Jichao , Liu Lu
Published: May 2023

Background

The purpose of this study is to construct a novel and practical nomogram and risk stratification system to accurately predict cancer-specific survival (CSS) of early-onset locally advanced rectal cancer (EO-LARC) patients.

Methods

A total of 2440 patients diagnosed with EO-LARC between 2010 and 2019 were screened from the Surveillance, Epidemiology, and End Results (SEER) database. The pool of potentially eligible patients was randomly divided into two groups: a training cohort (N=1708) and a validation cohort (N=732). The nomogram was developed and calibrated using various methods, including the coherence index (C-index), receiver operating characteristic curve (ROC), calibration curves, and decision curves (DCA). A new risk classification system was established based on the nomogram. To compare the performance of this nomogram to that of the American Joint Committee on Cancer (AJCC) staging system, DCA, net reclassification index (NRI), and integrated discrimination improvement (IDI) were employed.

Result

Seven variables were included in the model. The area under the ROC curve (AUC) for the training cohort was 0.766, 0.736, and 0.731 at 3, 6, and 9 years, respectively. Calibration plots displayed good consistency between actual observations and the nomogram’s predictions. The DCA curve further demonstrated the validity of the nomination form in clinical practice. Based on the scores of the nomogram, all patients were divided into a low-risk group, a middle-risk group, and a high-risk group. NRI for the 3-, 6-, and 9-year CSS(training cohort: 0.48, 0.45, 0.52; validation cohort: 0.42, 0.37, 0.37), IDI for the 3-, 6-, and 9-year CSS (training cohort: 0.09, 0.10, 0.11; validation cohort: 0.07, 0.08, 0.08). The Kaplan-Meier curve revealed that the new risk classification system possesses a more extraordinary ability to identify patients in different risk groups than the AJCC staging.

Conclusion

A practical prognostic nomogram and novel risk classification system have been developed to efficiently predict the prognosis of EO-LARC. These tools can serve as a guide to individualize patient treatment and improve clinical decision-making.
Investigation of 22Mg levels via resonant scattering of 18Ne + α
Authors: Cha S. M. , Chae K. Y. , Abe K. , Bae S. , Binh D. N. , Choi S. H. , Duy N. N. , Ge Z. , Hahn K. I. , Hayakawa S. , Hong B. , Iwasa N. , Kahl D. , Khiem L. H. , Kim A. , Kim D. , Kim E. J. , Kim G. W. , Kim M. J. , Kwak K. , Kwag M. S. , Lee E. J. , Lim S. I. , Moon B. , Moon J. Y. , Park S. Y. , Phong V. H. , Shimizu H. , Yamaguchi H. , Yang L.
Published: May 2023

The α resonant scattering on 18Ne was measured in inverse kinematics to understand the α-clustering of proton-rich 22Mg nucleus, performed at the CNS Radio-Isotope Beam Separator (CRIB) of Center for Nuclear Study, University of Tokyo, located at the RIBF of RIKEN Nishina Center. The excitation function of 22Mg was obtained for the excitation energies of 10–16 MeV by adopting the thick-target method. Several resonances were evident in the present work, which implies the existence of energy levels with large α widths. Since energy levels were not clearly observed at the astrophysically important energy range, upper limits on the 18Ne (α, α)18Ne cross section were set. The astrophysical impact was also investigated by estimating the 18Ne (α, p)21Na cross section.
Relationship between morphometric and mechanical properties of superficial lumbosacral soft tissue layers in healthy young adults
Authors: Grześkowiak Marcin , Kocur Piotr , Łochyński Dawid
Published: May 2023

Introduction: It is commonly considered that myotonometry is a non-invasive method capable of quantifying linear elastic and viscoelastic properties of the myofascial tissue through the application of a weak mechanical impulse to the surface of the skin. However, before the impulse can reach the myofascial tissue, it must cross more superficial tissues such as the skin and subcutaneous tissue (ST). All these superficial tissues have different distributions and organizations of structural components. Therefore, the study aimed to examine the potential relationships between the mechanical and morphometric properties of various superficial soft tissues surrounding the lumbar multifidus muscle (LM).

Methods: Myotonometric measurements of dynamic stiffness, logarithmic decrement, and creep, and ultrasonographic measurements of thickness and echogenicity of cutaneous, subcutaneous, perimuscular tissue, and LM were obtained from 50 healthy individuals in the resting prone position and during contralateral arm lift.

Results: The most important findings were that in both the relaxed and contracted LM state, the dynamic stiffness strongly negatively (r = −0.69; p < 0.001 in relaxation, r = −0.83; p < 0.001 in contraction) and creep strongly positively (r = 0.79; p < 0.001 in relaxation, r = 0.85; p < 0.001 in contraction) correlated with the thicknesses of the ST. Similar but weaker correlations were noticed between both these measures and the perimuscular tissue thickness. Elasticity was uncorrelated to the thicknesses of the tissues. With LM contraction (change from the relaxed to contracted state), the relative increase in dynamic stiffness was correlated with the relative decrease in dermis (r = −0.51; p < 0.001) and ST (r = −0.47; p = 0.001) thickness, and with the relative increase in LM (r = 0.36; p = 0.010) thickness. Moreover, the relative decrease (thinning) in the ST thickness was correlated with the relative increase in logarithmic decrement (i.e., decrease in soft tissue elasticity, r = −0.37, p = 0.011). The mechanical properties of the soft tissues were not related to their echogenicity.

Discussion: In conclusion, the thicker the subcutaneous and perimuscular layers, the lesser the stiffness and the greater the time-dependent deformation to the external force of the tissues surrounding the LM during its relaxation and isometric contraction. Moreover, the greater the thinning of the ST and the thickening of the LM during its contraction, the higher the increase in lumbosacral tissue stiffness and the decrease in elasticity. Therefore, one should consider the thickness of the ST before planning or analyzing the outcomes of myotonometric or other external biomechanical measurements to avoid drawing the wrong conclusions about the mechanical properties of the myofascial tissue.
A method and app for measuring the heterogeneous costs and benefits of justice processes
Authors: Manning Matthew , Wong Gabriel T. W. , Mahony Christopher , Vidanage Anushka
Published: May 2023

Can the impact of justice processes be enhanced with the inclusion of a heterogeneous component into an existing cost–benefit analysis (CBA) APP that demonstrates how benefactors and beneficiaries are affected? Such a component requires: (i) moving beyond the traditional cost benefit conceptual framework of utilising averages; (ii) identification of social group or population-specific variation; (iii) identification of how justice processes differ across groups/populations; (iv) distribution of costs and benefits according to the identified variations; and (v) utilisation of empirically informed statistical techniques to gain new insights from data and maximise impact to beneficiaries. In this paper, we outline a method for capturing heterogeneity. We test our method and the CBA online APP we developed using primary data collected from a developmental crime prevention intervention in Australia. We identify how subgroups in the intervention display different behavioural adjustments across the reference period revealing the heterogeneous distribution of costs and benefits. Finally, we discuss the next version of the CBA APP, which incorporates an AI-driven component that reintegrates individual CBA projects using machine learning and other modern data science techniques. We argue that the APP, enhances CBA, development outcomes, and policy making efficiency for optimal prioritization of criminal justice resources. Further, the APP advances policy accessibility of enhanced, social group-specific data illuminating policy orientation for more inclusive, just, and resilient societal outcomes.
Untreated depression and anxiety in patients with common skin diseases: a cross-sectional study in China
Authors: Tang Tao-Ran , Wang Mi , Li Hong , Yang Song-Chun , Zhang Cheng-Cheng , Lin Wen-Rui , Ke Xin-Chen , Zhang Han-Yi , Su Juan , Zhu Shi-Lin
Published: May 2023

Objective

The study aimed to analyze the current status and reasons for the neglect of the psychological need of patients with common skin diseases.

Methods

This cross-sectional study was conducted in China using an online self-assessment questionnaire distributed via social media. Demographic, clinical and psychological data were collected, and the main outcomes, i.e., depression (evaluated using the 9-item Patient Health Questionnaire, PHQ-9) and anxiety (evaluated using Generalized Anxiety Disorder-7, GAD-7). Multivariate regression analysis was used for the prediction of variates of mental health service seeking behaviors.

Results

A total of 1,010 patients participated in the survey, and 273 (27.0%) patients met the “with need” criteria, i.e., having the need for mental health intervention but not being treated. In the multivariate regression model, income (OR = 0.80, 95%CI: 0.65–0.99), duration of disease (OR = 0.68, 95%CI: 0.49–0.95) and suicide ideation (OR = 2.10, 95%CI: 1.14–3.87) were significant factors. For patients who did not receive mental health care, the lack of knowledge about the availability of mental health services, lack of knowledge of where to seek help, concerns about the side effects of treatment, failure to seek treatment for severe skin diseases, and absence of current psychological distress were associated with their need for psychological intervention.

Conclusion

This study examined the current status of the need for psychological intervention and the reasons why the need was unmet in patients with skin diseases. Due to the confusion and a lack of knowledge about their mental health issues, mental health services are often underutilized.
Meta-analysis of the efficacy of digital therapies in children with attention-deficit hyperactivity disorder
Authors: He Fan , Qi Yanjie , Zhou Yuanyue , Cao Aihua , Yue Xin , Fang Shuanfeng , Zheng Yi
Published: May 2023

Background

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that commonly occurs in childhood. The aim of this meta-analysis was to summarize the available evidence for the efficacy of digital therapeutics in children and adolescents with ADHD.

Methods

We searched the MEDLINE, EMBASE, Cochrane Library (Cochrane Database of Systematic Reviews), and Web of Science (science and social science citation index) databases for relevant studies and used Stata 15.0 software to carry out the meta-analysis.

Results

A total of 31 studies involving 2169 participants (1665 boys and 504 girls) aged 4–17 years old were included in the final analysis. The meta-analysis results showed that digital interventions improved the symptoms of inattention with an effect value of −0.20 (95% confidence interval [CI] −0.36, −0.04) and decreased the continuous performance task (CPT) reaction time (effect, −0.40, 95% CI −0.73, −0.07) in ADHD patients. The score for impulsive hyperactivity was slightly decreased (effect, −0.07, 95% CI −0.23, 0.09). Moreover, executive function was improved (effect, 0.71, 95% CI 0.37, 1.04). The capability of working memory appeared to be increased (effect, 0.48, 95% CI 0.21, 0.76) between the two groups. Visual appraisal of the sensitivity analysis suggested the absence of heterogeneity, and no obvious publication bias was detected.

Discussion

Based on the existing literature evidence, we conclude that digital therapy can be a promising therapeutic strategy for ADHD patients.
The impact of the pandemic on the perception of stress and danger, and the adjustment of psychiatric and general medical staff of German military hospitals
Authors: Willmund Gerd-Dieter , Müller Johannes , Schneegans Niels , Höllmer Helge , Wesemann Ulrich , Zimmermann Peter Lutz , Helms Christian
Published: May 2023

Introduction

The COVID-19 pandemic changed not only the working conditions but also the private conditions we live in. Health care professionals especially were confronted with multiple stressors, e.g., the risk of infection, lack of staff, and high workloads.

Methods

To estimate some of the pandemic-related impacts this anonymous personnel survey was conducted in two German military hospitals (Hamburg and Berlin). This study presents a comparative analysis of the hospital staff in general vs. the psychiatric personnel (N = 685) at two measurement time points (MTPs) in April 2021 (n = 399) and December 2021 (n = 286). The survey contains the German version of the Covid Stress Scale (CSS) to assess the perceived level of pandemic-related stress, the Patient Health Questionnaire (German Version: PHQ-D) to screen for three major mental disorders, and the adjustment disorder—New Module (ADNM) to estimate the problems of adaptation to change.

Results

The results showed a process of adaptation over the two MTPs with significant stress reduction at MTP2 in the general staff. The psychiatric staff did not report significantly higher pandemic-related symptoms. Quite the contrary, not only did the CSS show significantly lower xenophobia, traumatic stress, and compulsive checking, but the PHQ also showed lower stress symptoms and somatic symptoms at both MTPs. Also, the ADNM scores delivered evidence for a more effective adaptation process in psychiatric personnel (e.g., depressive mood, avoidance, anxiety).

Discussion

The presented results must be interpreted while taking the unique situations of German military clinics into account. The supply of protective material was sufficient and there was no dramatic shortage of psychiatric staff during the pandemic. The inpatients were quite often (40%) elective treatments for trauma-related disorders, which could be discontinued in the case of a COVID-19 infection. The results of this study showed good adaptative skills among the psychiatric staff in military hospitals, which could be interpreted as a sign of good resilience. This might have led to lower stress-related symptoms during the COVID-19 pandemic.
Switching from offline to online health consultation in the post-pandemic era: the role of perceived pandemic risk
Authors: Pan Xue , Zhou Xuecheng , Yu Lei , Hou Lei
Published: May 2023

Introduction

Due to its effectiveness and various benefits, the use of online health consultation (OHC) has dramatically increased in recent years, especially since the outbreak of the COVID-19 pandemic. However, underlying mechanism whereby the pandemic impacted OHC usage is still unclear.

Methods

Via an online survey (N=318), the present paper measures the users’ perceptions towards both offline and online services, their intention to switch to OHC, and the perceived pandemic risks. The relationships among these factors are conceptualized by the push-pull-mooring framework, and tested via structural equation modelling.

Results

Dissatisfaction with offline service (process inefficiency and consultation anxiety), the attractiveness of OHC (perceived benefits and perceived ease of use), and users’ behavioral inertia (switching cost and habit) jointly influence the intention to switching to OHC. The significant role of the perceived pandemic risk of going to medical facilities is particularly addressed. On the one hand, the perceived pandemic risk is found with an indirect impact on the switching intention by enlarging the dissatisfaction with offline service and the attractiveness of OHC. On the other hand, a high perceived pandemic risk induces more actual switching behavior and also amplifies the transition from switching intention to behavior.

Discussion

The study provides novel insights into the understanding of OHC usage in the post-pandemic era, and also informs medical facilities, OHC platforms, and policymakers on managing and balancing the online and offline healthcare provision.
Training and match load ratios in professional soccer–should we use player- or position-specific match reference values?
Authors: Ammann Linda , Altmann Stefan
Published: May 2023

Careful load management is needed to optimize the physical capacity, a key performance component, of soccer players. The training load of soccer players is often expressed as a percentage of match load. However, no study has yet evaluated how training match load ratios are affected by using either a player-specific or position-specific reference for match load. Therefore, this study aimed to compare training match load ratios of professional soccer players per day of a microcycle with match load being player-specific and position-specific, respectively. Additionally, the load that players typically experience per day of a microcycle and its variation should be analyzed. Therefore, a retrospective observational cohort study was conducted over a 14-month period, analyzing 11 external load measures during sessions of 20 players belonging to a team competing in the highest Swiss league. Within a microcycle, typical full matches presented a unique load for players, and they experienced higher training loads on days with a greater temporal distance to a match. Load variation proved to be highly associated with the day in a microcycle and the load measure. Substantial differences in typical load were evident in (i) trainings between players, (ii) matches both between players and positions, and (iii) training match load ratios when using player-specific or position-specific match references. The importance of individual load management in professional soccer was reaffirmed. When consulting training match load ratios for that purpose, one should be aware of the aim, select appropriate reference values depending on it, and interpret the ratios accurately to finally draw adequate conclusions.
Clinical outcomes of Najuta thoracic stent graft system for arch aneurysms
Authors: Iida Yasunori , Hachiya Takashi , Oka Hidetoshi , Inaba Yu , Miki Takahisa , Shimizu Hideyuki
Published: May 2023

Objectives

We aimed to elucidate the perioperative and short-term clinical outcomes of the Najuta thoracic stent graft system with fenestrations for supra-aortic vessels.

Methods

We retrospectively investigated the perioperative and short-term clinical outcomes of 20 patients treated for arch or distal arch aneurysms using the Najuta thoracic stent graft system during the period from May 2019 to February 2023.

Results

The technical success rate of the Najuta thoracic stent graft system was 95%. Of the 20 patients, 17 patients (85.0%) underwent concomitant extra-anatomical supra-aortic bypass. Postoperative CT revealed type Ia (n = 2) and type II (n = 3) endoleaks which disappeared on follow-up. The postoperative complications were stroke (n = 2, 10.0%), paraplegia (n = 1, 5.0%), and paraparesis (n = 1, 5.0%). In a very old patient, a blood transfusion was performed from the common iliac artery using the retroperitoneal approach. There were no aorta-related complications such as retrograde type A dissection or distal stent graft–induced new entry.

Conclusions

We treated arch or distal arch thoracic aneurysms by inserting a tube-type stent graft as a scaffold on the peripheral site and placing the Najuta thoracic stent graft on the proximal site. By extending the landing zone to Zone 0 and using a low radial force, which is a feature of the Najuta thoracic stent graft system, postoperative bird-beak and aorta-related complications were avoided. The treatment of arch and distal arch aortic aneurysms using the Najuta thoracic stent graft system showed acceptable perioperative and short-term clinical outcomes. Thoracic endovascular aortic repair using the Najuta thoracic stent graft system may be a potential treatment option for arch and distal arch aortic aneurysms, warranting further studies.
Investigation of the Free-Fall Dynamic Behavior of a Rectangular Wing with Variable Center of Mass Location and Variable Moment of Inertia
Authors: Dou Yilin , Wang Kelei , Zhou Zhou , Thomas Peter R. , Shao Zhuang , Du Wanshan
Published: May 2023

In recent years, the air-drop launch technology of near-space UAVs has attracted much attention. Between downfall from the carrier and the flight control system’s initiation, the UAV presents free-fall movement. This free-fall process is very important for the control effect of the flight control system and is also crucial for the safety of the UAV and the carrier. Focus is required on two important dynamic parameters of the UAV: the moment of inertia and the center of mass position. In this paper, we used a quasi-steady model proposed by predecessors to address the flat-plate falling problem with modifications to describe the freely falling motion of the wing. Computational fluid dynamics (CFD) were used to simulate the free-fall movement of the wing with various parameters, and the wing release behavior was analyzed to check the quasi-steady model. Research shows that the movement characteristics of the falling wing are mostly reflected in the longitudinal plane, and the developed quasi-steady analytical model can more accurately describe the dynamic behavior of free-fall to some extent. By using CFD methods, we further investigated the aerodynamic performance of the free-fall wing. The results show that the wing mainly presents tumbling and fluttering motion. Changing the moment of inertia around the tumbling axis changes the tumbling frequency and the time point as the wing enters tumbling. In contrast, changing the position of the center of mass significantly changes the form of falling and makes the free-fall motion more complex. Therefore, it is necessary to carefully configure the center of mass in the UAV design process.
Does Nitrofurantoin Improve the Portfolio of Vets against Resistant Bacteria in Companion Animals?
Authors: Vercelli Cristina , Amadori Michela , Gambino Graziana , Re Giovanni
Published: May 2023

In clinical practice in dogs and cats, antimicrobials are frequently used, sometimes overused or misused, increasing antimicrobial resistance (AMR). In order to limit the phenomenon, laws have been enacted and guidelines for prudent and rational use of antibiotics have been developed. Interestingly, old molecules such as nitrofurantoin could be used to achieve therapeutic success and overcome AMR. To better understand the suitability of this molecule in veterinary medicine, the authors performed a revision of the literature, searching on PubMed and entering the following keywords: nitrofurantoin, veterinary medicine, dog, and cat connected by the Boolean operator “and”, without restrictions on the date of publication. Thirty papers were finally selected. It is possible to appreciate that papers dealing with nitrofurantoin have been written from the early 1960s to the middle of the 1970s, and then a long period passed without publications. Only at the beginning of the new century, nitrofurantoin was included or was sometimes the focus of papers dealing with its efficacy in veterinary medicine, mainly in the treatment of urinary tract infections. One recent paper dealt with pharmacokinetic features, and none was dedicated to pharmacokinetic/pharmacodynamic integration or modeling. Nitrofurantoin appears to be still effective against several pathogens that rarely develop resistance to this molecule.
Epidemiological Impact on Use of Antibiotics in Patients Hospitalized for COVID-19: A Retrospective Cohort Study in Italy
Authors: Maraia Zaira , Mazzoni Tony , Turtora Miriana Pia , Tempera Alessandra , Spinosi Marco , Vagnoni Anita , Mazzoni Isidoro
Published: May 2023

The increased incidence of antimicrobial resistance during coronavirus disease 2019 (COVID-19) is a very important collateral damage of global concern. The cause is multifactorial and is particularly related to the high rates of antibiotic use in COVID-19 patients with a relatively low rate of secondary co-infection. To this end, we conducted a retrospective observational study of 1269 COVID-19 patients admitted during the years 2020, 2021 and 2022 in two Italian hospitals, with a focus on bacterial co-infections and antimicrobial therapy. Multivariate logistic regression was used to analyze the association between bacterial co-infection, antibiotic use and hospital death after adjustment for age and comorbidity. Bacterial co-infection was detected in 185 patients. The overall mortality rate was 25% (n = 317). Concomitant bacterial infections were associated with increased hospital mortality (β = 1.002, p < 0.001). A total of 83.7% (n = 1062) of patients received antibiotic therapy, but only 14.6% of these patients had an obvious source of bacterial infection. There was a significantly higher rate of hospital mortality in patients who received antibiotics than in those who did not (χ2 = 6.22, p = 0.012). Appropriate prescribing and the rational use of antimicrobials according to the principles of antimicrobial stewardship can help prevent the emergence of antibiotic resistance.
Special Issue “BIM Implementation to Meet the Changing Demands of the Construction Industry”
Authors: Coates Stephen Paul
Published: May 2023

Effective Building Information Modelling implementation continues to evolve, aligning itself to the changing needs of the construction industry [...]
Investigating the Number of Monte Carlo Simulations for Statistically Stationary Model Outputs
Authors: Zhang Jiahang , Cui Shengai
Published: May 2023

The number of random fields required to capture the spatial variability of soil properties and their impact on the performance of geotechnical systems is often varied. However, the number of random fields required to obtain higher-order statistical moments of model outputs has not yet been studied. This research aims to investigate the number of Monte Carlo simulations needed to achieve stationary higher-order statistics of a pore pressure head in an unsaturated soil slope under steady-state infiltration. The study recommends using at least 500 Monte Carlo samples for the probabilistic analysis of geotechnical engineering models. A more conservative choice for up to second-moment analysis is 1000 samples. The analysis reveals significant variations in skewness, which become stationary for all mesh grids when the number of samples exceeds 15,000. Kurtosis stabilizes only when the number of samples reaches 25,000. The pore pressure head in the unsaturated zone is less uncertain. Additionally, the probability density function of the pore pressure head follows a leptokurtic distribution.
Effect of LED Illumination Cycle and Carbon Sources on Biofilms of Haematococcus pluvialis in Pilot-Scale Angled Twin-Layer Porous Substrate Photobioreactors
Authors: Do Thanh-Tri , Quach-Van Toan-Em , Nguyen Thanh-Cong , Show Pau Loke , Nguyen Tran Minh-Ly , Huynh Duc-Hoan , Tran Dai-Long , Melkonian Michael , Tran Hoang-Dung
Published: May 2023

Light-emitting diodes are increasingly used as artificial light sources in Haematococcus pluvialis cultivation due to the fact of their energy advantages. The immobilized cultivation of H. pluvialis in pilot-scale angled twin-layer porous substrate photobioreactors (TL-PSBRs) was initially performed with a 14/10 h light/dark cycle and showed relatively low biomass growth and astaxanthin accumulation. In this study, the illumination time with red and blue LEDs at a light intensity of 120 µmol photons m−2 s−1 was increased to 16–24 h per day. With a light/dark cycle of 22/2 h, the biomass productivity of the algae was 7.5 g m−2 day−1, 2.4 times higher than in the 14/10 h cycle. The percentage of astaxanthin in the dry biomass was 2%, and the total amount of astaxanthin was 1.7 g m−2. Along with the increase in light duration, adding 10 or 20 mM NaHCO3 to the BG11-H culture medium over ten days of cultivation in angled TL-PSBRs did not increase the total amount of astaxanthin compared with only CO2 addition at a flow rate of 3.6 mg min−1 to the culture medium. Adding NaHCO3 with a 30–80 mM concentration inhibited algal growth and astaxanthin accumulation. However, adding 10–40 mM NaHCO3 caused algal cells to accumulate astaxanthin at a high percentage in dry weight after the first four days in TL-PSBRs.
Biomarkers of Atrial Fibrillation Recurrence in Patients with Paroxysmal or Persistent Atrial Fibrillation Following External Direct Current Electrical Cardioversion
Authors: Demirel Ozan , Berezin Alexander E. , Mirna Moritz , Boxhammer Elke , Gharibeh Sarah X. , Hoppe Uta C. , Lichtenauer Michael
Published: May 2023

Atrial fibrillation (AF) is associated with atrial remodeling, cardiac dysfunction, and poor clinical outcomes. External direct current electrical cardioversion is a well-developed urgent treatment strategy for patients presenting with recent-onset AF. However, there is a lack of accurate predictive serum biomarkers to identify the risks of AF relapse after electrical cardioversion. We reviewed the currently available data and interpreted the findings of several studies revealing biomarkers for crucial elements in the pathogenesis of AF and affecting cardiac remodeling, fibrosis, inflammation, endothelial dysfunction, oxidative stress, adipose tissue dysfunction, myopathy, and mitochondrial dysfunction. Although there is ample strong evidence that elevated levels of numerous biomarkers (such as natriuretic peptides, C-reactive protein, galectin-3, soluble suppressor tumorigenicity-2, fibroblast growth factor-23, turn-over collagen biomarkers, growth differential factor-15) are associated with AF occurrence, the data obtained in clinical studies seem to be controversial in terms of their predictive ability for post-cardioversion outcomes. Novel circulating biomarkers are needed to elucidate the modality of this approach compared with conventional predictive tools. Conclusions: Biomarker-based strategies for predicting events after AF treatment require extensive investigation in the future, especially in the presence of different gender and variable comorbidity profiles. Perhaps, a multiple biomarker approach exerts more utilization for patients with different forms of AF than single biomarker use.
Nanobubble Technology for A Water-Repellent Treatment on Cotton Fabrics: A Comparative Study
Authors: Zouari Abir , Manich Albert , Marti Meritxell , Gargoubi Sondes , Boudokhane Chedly
Published: May 2023

Recently, a significant interest in eco-friendly textile products and processes has been noted among consumers and producers. In this respect, nanobubble technology is emerging as a green alternative. In this study, water-repellent cotton fabrics were produced with exhaustion and nanobubble technology (e-flow method) using a short-chain fluoropolymer. The currently most developed substituents are based on molecules with short fluorine carbon chains. The wettability, mechanical properties, air permeability and treatment durability were evaluated. The untreated and treated cotton fabrics were analyzed with ATR-FTIR (Fourier transform infrared attenuated total reflectance) and SEM (scanning electron microscopy) to reveal chemical and morphological modifications. The obtained results show that cotton samples treated with short-chain fluoropolymers, nontoxic and eco-friendly finishing chemicals, and nanobubble technology have good water repellence and good washing durability. Due to their size and structure, nanobubbles possess distinct properties that make them particularly effective at improving water quality, enhancing water treatment processes, and improving productivity in industrial applications. Nanobubbles have a strong negative surface charge that keeps them stable in liquid, prevents them from coalescing, and enables them to physically separate small particles and droplets from water, such as emulsified fats, oils, and grease.