bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Mendelian Randomization to Study the Role of Iron in Health and Disease
Authors: Zeitoun Tara , El-Sohemy Ahmed
Published: August 2023

Iron has been shown to play a dual role in health and disease, with either a protective or harmful effect. Some of the contradictory findings from observational studies may be due to reverse causation, residual confounding, or small sample size. One approach that may overcome these limitations without the high cost of randomized control trials is the use of Mendelian randomization to examine the long-term role of iron in a variety of health outcomes. As there is emerging evidence employing Mendelian randomization as a method of assessing the role of micronutrients in health and disease, this narrative review will highlight recent Mendelian randomization findings examining the role of iron in cardiometabolic disorders, inflammation, neurological disorders, different cancers, and a number of other health-related outcomes.
Can Genetic Markers Predict the Sporadic Form of Alzheimer’s Disease? An Updated Review on Genetic Peripheral Markers
Authors: Theron Danelda , Hopkins Lloyd N. , Sutherland Heidi G. , Griffiths Lyn R. , Fernandez Francesca
Published: August 2023

Alzheimer’s disease (AD) is the most common form of dementia that affects millions of individuals worldwide. Although the research over the last decades has provided new insight into AD pathophysiology, there is currently no cure for the disease. AD is often only diagnosed once the symptoms have become prominent, particularly in the late-onset (sporadic) form of AD. Consequently, it is essential to further new avenues for early diagnosis. With recent advances in genomic analysis and a lower cost of use, the exploration of genetic markers alongside RNA molecules can offer a key avenue for early diagnosis. We have here provided a brief overview of potential genetic markers differentially expressed in peripheral tissues in AD cases compared to controls, as well as considering the changes to the dynamics of RNA molecules. By integrating both genotype and RNA changes reported in AD, biomarker profiling can be key for developing reliable AD diagnostic tools.
Cancer-Associated Fibroblast Heterogeneity and Its Influence on the Extracellular Matrix and the Tumor Microenvironment
Authors: Knipper Karl , Lyu Su , Quaas Alexander , Bruns Christiane , Schmidt Thomas
Published: August 2023

The tumor microenvironment comprises multiple cell types, like cancer cells, endothelial cells, fibroblasts, and immune cells. In recent years, there have been massive research efforts focusing not only on cancer cells, but also on other cell types of the tumor microenvironment, thereby aiming to expand and determine novel treatment options. Fibroblasts represent a heterogenous cell family consisting of numerous subtypes, which can alter immune cell fractions, facilitate or inhibit tumor growth, build pre-metastatic niches, or stabilize vessels. These effects can be achieved through cell–cell interactions, which form the extracellular matrix, or via the secretion of cytokines or chemokines. The pro- or antitumorigenic fibroblast phenotypes show variability not only among different cancer entities, but also among intraindividual sites, including primary tumors or metastatic lesions. Commonly prescribed for arterial hypertension, the inhibitors of the renin–angiotensin system have recently been described as having an inhibitory effect on fibroblasts. This inhibition leads to modified immune cell fractions and increased tissue stiffness, thereby contributing to overcoming therapy resistance and ultimately inhibiting tumor growth. However, it is important to note that the inhibition of fibroblasts can also have the opposite effect, potentially resulting in increased tumor growth. We aim to summarize the latest state of research regarding fibroblast heterogeneity and its intricate impact on the tumor microenvironment and extracellular matrix. Specifically, we focus on highlighting recent advancements in the comprehension of intraindividual heterogeneity and therapy options within this context.
Unveiling the Confirmation Factors of Information System Quality on Continuance Intention towards Online Cryptocurrency Exchanges: The Extension of the Expectation Confirmation Model
Authors: Lee Hsu-Hua , Sung Hui-Chun
Published: August 2023

This study is based on the Expectation Confirmation Model and the Information System Success Model to evaluate the influence of perceived usefulness and satisfaction towards online cryptocurrency exchanges. Therefore, this study deconstructs the “confirmation” component of the information system continuous use model into three different components: confirmation of information quality, confirmation of system quality, and confirmation of service quality, to investigate the factors that influence the desire to use online cryptocurrency exchanges continuously. This research used a questionnaire methodology, with data collected from 248 users of cryptocurrency platforms. This study found that perceived usefulness and satisfaction significantly correlated with continuance intention. Furthermore, information quality, system quality, and service quality significantly correlated with perceived usefulness and satisfaction. Finally, perceived usefulness was found to be significantly correlated with satisfaction.
Design and Construction of a Device to Evaluate the Performance of Variable Orifice Flow Meters (VOFM)
Authors: Prado Martínez William , Arroyave Londoño Juan Felipe , Vásquez Gómez Jefferson
Published: August 2023

This work presents a low-cost device for evaluating Variable Orifice Flow Meters (VOFM) used in medical mechanical ventilation applications. Specifically, the equipment was used to assess the impact of length and thickness on pressure drop for different flows in a rectangular geometry VOFM. A total of six VOFMs, with three different lengths and two different thicknesses, were evaluated. All VOFMs were stimulated with an airflow ranging from 0 L.min−1 to 90 L.min−1, with increments of approximately 2 L.min−1. The experiments conducted with the device showed a strong relationship between pressure drop ∆P and flow rate Q in the evaluated VOFMs, with two different zones: one exhibiting non-linear behavior and another showing linear behavior. The results suggest that increased length and decreased thickness lead to higher sensitivity. However, it is essential to reduce the cross-sectional area to mitigate nonlinear effects of the sensor.
APOE ε4 Gene Carriers Demonstrate Reduced Retinal Capillary Densities in Asymptomatic Older Adults
Authors: Zhang Ziyi , Kwapong William Robert , Cao Le , Feng Zijuan , Wu Bo , Liu Junfeng , Zhang Shuting
Published: August 2023

Early identification of Apolipoprotein E (APOE)-related microvascular pathology will help to study the microangiopathic contribution to Alzheimer’s disease and provide a therapeutic target for early intervention. To evaluate the differences in retinal microvasculature parameters between APOE ε4 carriers and non-carriers, asymptomatic older adults aged ≥ 55 years underwent APOE ε4 genotype analysis, neuropsychological examination, and optical coherence tomography angiography (OCTA) imaging. One hundred sixty-three older adults were included in the data analysis. Participants were also defined as cognitively impaired (CI) and non-cognitively impaired (NCI) according to their MoCA scores and educational years. APOE ε4 carriers demonstrated reduced SVC (p = 0.023) compared to APOE ε4 non-carriers. Compared to NCI, CI participants showed reduced SVC density (p = 0.006). In the NCI group, no significant differences (p > 0.05) were observed in the microvascular densities between APOE ε4 carriers and non-carriers. In the CI group, APOE ε4 carriers displayed reduced microvascular densities compared to non-carriers (SVC, p = 0.006; DVC, p = 0.048). We showed that CI and APOE ε4 affect retinal microvasculature in older adults. Quantitative measures of the retinal microvasculature could serve as surrogates for brain microcirculation, providing an opportunity to study microvascular contributions to AD.
Bioactivity of Fucoidan-Rich Extracts from Fucus vesiculosus against Rotavirus and Foodborne Pathogens
Authors: Graikini Dimitra , Soro Arturo B. , Sivagnanam Saravana P. , Tiwari Brijesh K. , Sánchez Lourdes
Published: August 2023

Marine algae are sources of bioactive components with defensive properties of great value against microbial infections. This study investigated the bioactivity of extracts from brown algae Fucus vesiculosus against rotavirus, the worldwide leading cause of acute gastroenteritis in infants and young children. Moreover, one of the extracts was tested against four foodborne bacteria: Campylobacter jejuni, Escherichia coli, Salmonella Typhimurium, and Listeria monocytogenes, and the non-pathogenic: E. coli K12. In vitro tests using MA104 cells revealed that both whole algae extracts and crude fucoidan precipitates neutralized rotavirus in a dose-responsive manner. The maximum neutralization activity was observed when the rotavirus was incubated with 100 μg mL−1 of the hydrochloric acid-obtained crude fucoidan (91.8%), although crude fucoidan extracted using citric acid also demonstrated high values (89.5%) at the same concentration. Furthermore, molecular weight fractionation of extracts decreased their antirotaviral activity and high molecular weight fractions exhibited higher activity compared to those of lower molecular weight. A seaweed extract with high antirotaviral activity was also found to inhibit the growth of C. jejuni, S. Typhimurium, and L. monocytogenes at a concentration of 0.2 mg mL−1. Overall, this study expands the current knowledge regarding the antimicrobial mechanisms of action of extracts from F. vesiculosus.
Suggestion of a Novel Classification Based on the Anatomical Region and Type of Bilateral Fatigue Femoral Fractures
Authors: Koutserimpas Christos , Kotzias Dimitrios , Chronopoulos Efstathios , Naoum Symeon , Raptis Konstantinos , Karamitros Athanasios , Dretakis Konstantinos , Piagkou Maria
Published: August 2023

Purpose: Bilateral fatigue femoral fractures (BFFF) represent an extremely rare clinical entity. The present study introduces a novel classification, in order to categorize the BFFFs and provide a thorough review of all these, so far in the literature, reported cases. Methods: The BFFF were classified taking into account the anatomical region of the femoral fracture; (fh): femoral head, (sc): sub-capital, (pt): peri-trochanteric, (st): sub-trochanteric, (s): shaft, (d): distal femur and the fracture type (complete or incomplete); type I: bilateral incomplete fractures, type II: unilateral incomplete fracture, and type III: bilateral complete fractures. Type III was further subdivided into type IIIA: bilateral non-displaced fractures, type IIIB: unilateral displaced fracture, and type IIIC: bilateral displaced fractures. Furthermore, a meticulous review of the PubMed and MEDLINE databases was conducted to locate all articles reporting these injuries. Results: A total of 38 patients (86.8% males), with a mean age of 25.3 years, suffering BFFFs were identified from the literature search. The mean time interval from symptoms’ onset to diagnosis was 54 days. According to the proposed classification, 2.6% of the fractures were categorized as type I (h), 36.8% as type I (sc), 2.6% as type I(st/s), 7.9% as type I (s), 2.6% as type I (d), 5.4% as type II (fh), 26.3% as type II (sc), 2.6% as type IIIA (st), 2.6% as type IIIA (d), 5.4% as type IIIB (sc), 2.6% as type IIIB (d) and 2.6% as type IIIC (sc). Surgery was performed in 52.6%, while non-operative treatment was followed in 47.4% of the population. Regarding the fracture type, 75% of type I fractures were conservatively treated, while 91.7% and 66.6% of type II and III fractures were surgically treated. For patients treated conservatively, the mean time from diagnosis to return to previous status was 260 days, while for patients treated surgically, 343 days. Conclusions: BFFFs, although rare, may pose a diagnostic and therapeutic challenge. The present classification offers valuable information and may act as a guide for the management of these patients.
Prognostic Tools for Older Women with Breast Cancer: A Systematic Review
Authors: Record Sydney M. , Chanenchuk Tori , Parrish Kendra M. , Kaplan Samantha J. , Kimmick Gretchen , Plichta Jennifer K.
Published: August 2023

Background: Breast cancer is the most common cancer in women, and older patients comprise an increasing proportion of patients with this disease. The older breast cancer population is heterogenous with unique factors affecting clinical decision making. While many models have been developed and tested for breast cancer patients of all ages, tools specifically developed for older patients with breast cancer have not been recently reviewed. We systematically reviewed prognostic models developed and/or validated for older patients with breast cancer. Methods: We conducted a systematic search in 3 electronic databases. We identified original studies that were published prior to 8 November 2022 and presented the development and/or validation of models based mainly on clinico-pathological factors to predict response to treatment, recurrence, and/or mortality in older patients with breast cancer. The PROBAST was used to assess the ROB and applicability of each included tool. Results: We screened titles and abstracts of 7316 records. This generated 126 studies for a full text review. We identified 17 eligible articles, all of which presented tool development. The models were developed between 1996 and 2022, mostly using national registry data. The prognostic models were mainly developed in the United States (n = 7; 41%). For the derivation cohorts, the median sample size was 213 (interquartile range, 81–845). For the 17 included modes, the median number of predictive factors was 7 (4.5–10). Conclusions: There have been several studies focused on developing prognostic tools specifically for older patients with breast cancer, and the predictions made by these tools vary widely to include response to treatment, recurrence, and mortality. While external validation was rare, we found that it was typically concordant with interval validation results. Studies that were not validated or only internally validated still require external validation. However, most of the models presented in this review represent promising tools for clinical application in the care of older patients with breast cancer.
Investigating Bioaccessibility of Advanced Glycation Product Precursors in Gluten-Free Foods Using In Vitro Gastrointestinal System
Authors: Serin Yeliz , Akbulut Gamze , Yaman Mustafa
Published: August 2023

Background and Objectives: Gluten-free products have been produced as part of medical therapy and have gained popularity among individuals seeking weight loss or healthier dietary options. Assessing the potential risks associated with these products is essential in optimizing their compositions and developing new dietetic approaches. This study aimed to determine the glyoxal (GO) and methylglyoxal (MGO) contents in gluten-free bread, biscuits, and cookies and to examine their bioaccessibility using an in vitro gastrointestinal model. Materials and Methods: A total of 26 gluten-free and 19 gluten-containing (control) products were analyzed for their GO and MGO levels utilizing a high-performance liquid chromatography (HPLC) device. Results: Post-digestion, the GO and MGO values increased significantly across all food groups compared with pre-digestion values (p < 0.05), and the bioaccessibility exceeded 100%. Specifically, gluten-free bread exhibited higher post-digestion GO and MGO values than the control group (p < 0.05). Conversely, gluten-containing biscuits and cookies had higher post-digestion GO and MGO values compared to gluten-free products (p < 0.05). Conclusions: The detection of precursors to advanced glycation end products (AGEs) in gluten-free products has drawn attention to the potential health risks associated with their consumption. Therefore, reevaluation of the formulations and technologies used in these products and the introduction of new strategies are crucial in mitigating AGE content.
Gene Expression of Monoterpene Synthases Is Affected Rhythmically during the Day in Lavandula angustifolia Flowers
Authors: Seira Eleftheria , Poulaki Stefania , Hassiotis Christos , Poulios Stylianos , Vlachonasios Konstantinos E.
Published: August 2023

Lavender essential oil (EO) is widely used for medicinal purposes. The significant monoterpenes’ abundance of linalool and linalool acetate accounts for more than 50% of lavender EO compounds. Monoterpenes synthesis differs throughout plant development as a result of the differential gene expression patterns in distinct cell types. Previously, we have reported that the chemical composition of Lavandula angustifolia cv. etherio EO was affected by diurnal harvest time. The aim of this was to evaluate if the gene expression of lavender monoterpenes synthases is altered during the day length and correlated with the accumulation of the major components of lavender EO. The relative expression of linalool synthase (LaLINS), limonene synthase (LaLIMS) and terpene synthase-like (LaTPS-l) was recorded in flowers at the 3rd to 5th stage every 3 h during two consecutive days using quantitative real-time PCR. The composition of the lavender EO was also monitored during the day length using GC-MS analysis. Our results indicate that the expression of genes involved in the synthesis of lavender EO, including linalool and limonene synthases, is accompanied by oscillations, picking at mid-day and leading to linalool acetate accumulation in the afternoon. In conclusion, the monoterpenes synthase expression in lavender flowers is rhythmically affected during the day, leading to a higher accumulation of EO compounds in the afternoon. These results will be helpful to monitor the biosynthesis of lavender EO to ensure a high-quality product. Furthermore, the outcome of this study will be useful for breeding programs in the lavender field to modulate the biosynthesis of linalool and linalool acetate during the flowering harvest period.
Lactic Acid Fermentation of Carrageenan Hydrolysates from the Macroalga Kappaphycus alvarezii: Evaluating Different Bioreactor Operation Modes
Authors: Tabacof Adam , Calado Verônica , Pereira Nei
Published: August 2023

Lactic acid is a molecule used abundantly in the food, cosmetic, and pharmaceutical industries. It is also the building block for polylactic acid, a biodegradable polymer which has gained interest over the last decade. Seaweeds are fast growing, environmentally friendly, and economically beneficial. The Rhodophyta, Kappaphycus alvarezii, is a carrageenan-rich alga, which can be successfully fermented into lactic acid using lactic acid bacteria. Lactobacillus pentosus is a versatile and robust bacterium and an efficient producer of lactic acid from many different raw materials. Bioreactor strategies for lactic acid fermentation of K. alvarezii hydrolysate were tested in 2-L stirred-tank bioreactor fermentations, operating at 37 °C, pH 6, and 150 rpm. Productivity and yields were 1.37 g/(L.h) and 1.17 g/g for the pulse fed-batch, and 1.10 g/(L.h) and 1.04 g/g for extended fed-batch systems. A 3.57 g/(L.h) production rate and a 1.37 g/g yield for batch fermentation operating with an inoculum size of 0.6 g/L was recorded. When applying fed-batch strategies, fermentation products reached 91 g/L with pulse feed and 133 g/L with constant continuous feed. For control and comparison, a simple batch of synthetic galactose-rich Man-Sharpe-Rugosa (MRS) media was fermented at the same conditions. A short study of charcoal regenerability is shown. A scheme for a third-generation lactic acid biorefinery is proposed, envisioning a future sustainable large-scale production of this important organic acid.
An Enhanced Food Digestion Algorithm for Mobile Sensor Localization
Authors: Chu Shu-Chuan , Shao Zhi-Yuan , Zhong Ning , Liu Geng-Geng , Pan Jeng-Shyang
Published: August 2023

Mobile sensors can extend the range of monitoring and overcome static sensors’ limitations and are increasingly used in real-life applications. Since there can be significant errors in mobile sensor localization using the Monte Carlo Localization (MCL), this paper improves the food digestion algorithm (FDA). This paper applies the improved algorithm to the mobile sensor localization problem to reduce localization errors and improve localization accuracy. Firstly, this paper proposes three inter-group communication strategies to speed up the convergence of the algorithm based on the topology that exists between groups. Finally, the improved algorithm is applied to the mobile sensor localization problem, reducing the localization error and achieving good localization results.
The Proper Use of Fibre-Optic Sensors to Monitor the Condition of the Steam Boiler Hanger Rods
Authors: Palacz Magdalena , Bąk Bolesław , Felkowski Łukasz , Duda Piotr , Iliev Iliya
Published: August 2023

Fibre optic sensors with integrated Bragg gratings are widely used in the diagnostics of machinery and equipment. They achieved their popularity thanks to their relatively simple operating principles. In addition, they allow the continuous monitoring of several variable physical parameters of objects, such as strain or temperature change, which directly translates into immediate feedback regarding potential damage. However, despite the easy-to-understand operating principle, selecting a specific type for a particular application can be problematic. This article aims to present the process of selecting the optimal set of fibre-optic sensors with integrated Bragg grating, which can be used in the process of monitoring the stress state of hanger rods of an engineering object such as an industrial boiler. The hanger rods of such boilers require constant technical supervision; however, the current measurement methods do not provide an effective and non-invasive diagnostic method. Therefore, the authors have undertaken the task of developing a universal diagnostic strategy for hanger rods. To this end, they will present the results of an analysis of the applicability of FBGs, examples of the use of different types of sensors, their installation methods, and the technical capabilities of the equipment necessary to handle the signals recorded with these sensors. Exemplary results of strain measurements of a selected hanger rod performed by the traditional method used now and with a selected FBG fibre optic sensor will be presented. In conclusion, concrete technical suggestions will be presented to be implemented in the existing industrial facility during the next part of the study.
Selective Detection of Erythrocytes with QCMs—ABO Blood Group Typing
Authors: Latif Usman , Seifner Alexandra , Dickert Franz L.
Published: August 2023

Blood transfusion, as well as organ transplantation, is only possible after prior blood group (BG) typing and crossmatching. The most important blood group system is that of Landsteiner’s ABO classification based on antigen presence on the erythrocyte surfaces. A mass sensitive QCM (quartz crystal microbalance) sensor for BG typing has been developed by utilizing molecular imprinting technology. Polyvinylpyrrolidone (crosslinked with N,N-methylenebisacrylamide) is a favorable coating that was imprinted with erythrocytes of different blood groups. In total, 10 MHz quartz sheets with two resonators, one for MIP (molecularly imprinted polymer) and the other for NIP (non-imprinted polymer) were fabricated and later used for mass-sensitive measurements. The structure of erythrocyte imprints resembles a donut, as identified by AFM (atomic force microscope). All the erythrocytes of the ABO system were chosen as templates and the responses to these selective coatings were evaluated against all blood groups. Each blood group can be characterized by the pattern of responses in an unambiguous way. The results for blood group O are remarkable given that all types of erythrocytes give nearly the same result. This can be easily understood as blood group O does not possess neither antigen A nor antigen B. The responses can be roughly related to the number of respective antigens on the erythrocyte surface. The imprints generate hollows, which are used for reversible recognition of the erythrocytes. This procedure is based on molecular recognition (based on supramolecular strategies), which results from size, shape and enthalpic interactions between host and guest molecules.
Deep Sensing for Compressive Video Acquisition
Authors: Yoshida Michitaka , Torii Akihiko , Okutomi Masatoshi , Taniguchi Rin-ichiro , Nagahara Hajime , Yagi Yasushi
Published: August 2023

A camera captures multidimensional information of the real world by convolving it into two dimensions using a sensing matrix. The original multidimensional information is then reconstructed from captured images. Traditionally, multidimensional information has been captured by uniform sampling, but by optimizing the sensing matrix, we can capture images more efficiently and reconstruct multidimensional information with high quality. Although compressive video sensing requires random sampling as a theoretical optimum, when designing the sensing matrix in practice, there are many hardware limitations (such as exposure and color filter patterns). Existing studies have found random sampling is not always the best solution for compressive sensing because the optimal sampling pattern is related to the scene context, and it is hard to manually design a sampling pattern and reconstruction algorithm. In this paper, we propose an end-to-end learning approach that jointly optimizes the sampling pattern as well as the reconstruction decoder. We applied this deep sensing approach to the video compressive sensing problem. We modeled the spatio–temporal sampling and color filter pattern using a convolutional neural network constrained by hardware limitations during network training. We demonstrated that the proposed method performs better than the manually designed method in gray-scale video and color video acquisitions.
Identification of Driver Status Hazard Level and the System
Authors: Gong Jiayuan , Zhou Shiwei , Ren Wenbo
Published: August 2023

According to the survey statistics, most traffic accidents are caused by the driver’s behavior and status irregularities. Because there is no multi-level dangerous state grading system at home and abroad, this paper proposes a complex state grading system for real-time detection and dynamic tracking of the driver’s state. The system uses OpenMV as the acquisition camera combined with the cradle head tracking system to collect the driver’s current driving image in real-time dynamically, combines the YOLOX algorithm with the OpenPose algorithm to judge the driver’s dangerous driving behavior by detecting unsafe objects in the cab and the driver’s posture, and combines the improved Retinaface face detection algorithm with the Dlib feature-point algorithm to discriminate the fatigue driving state of the driver. The experimental results show that the accuracy of the three driver danger levels (R1, R2, and R3) obtained by the proposed system reaches 95.8%, 94.5%, and 96.3%, respectively. The experimental results of this system have a specific practical significance in driver-distracted driving warnings.
Co-Efficient Vector Based Differential Distributed Quasi-Orthogonal Space Time Frequency Coding
Authors: Nwanekezie Nnamdi , Simpson Oluyomi , Owojaiye Gbenga , Sun Yichuang
Published: August 2023

Distributed space time frequency coding (DSTFC) schemes address problems of performance degradation encountered by cooperative broadband networks operating in highly mobile environments. Channel state information (CSI) acquisition is, however, impractical in such highly mobile environments. Therefore, to address this problem, designers focus on incorporating differential designs with DSTFC for signal recovery in environments where neither the relay nodes nor destination have CSI. Traditionally, unitary matrix-based differential designs have been used to generate the differentially encoded symbols and codeword matrices. Unitary based designs are suitable for cooperative networks that utilize the amplify-and-forward protocol where the relay nodes are typically required to forego differential decoding. In considering other scenarios where relay nodes are compelled to differentially decode and re-transmit information signals, we propose a novel co-efficient vector differential distributed quasi-orthogonal space time frequency coding (DQSTFC) scheme for decode-and-forward cooperative networks. Our proposed space time frequency coding scheme relaxes the need for constant channel gain in the temporal and frequency dimensions over long symbol periods; thus, performance degradation is reduced in frequency-selective and time-selective fading environments. Simulation results illustrate the performance of our proposed co-efficient vector differential DQSTFC scheme under different channel conditions. Through pair-wise error probability analysis, we derive the full diversity design criteria for our code.
Le gisement de stèles funéraires et autels antiques de l’anse Saint-Gervais (Fos-sur-Mer) : étude documentaire, archéologique et épigraphique
Authors: Marty Frédéric , Courrier Cyril , Fontaine Souen , Bromblet Philippe , Domzalski Adrien , El Amouri Mourad
Published: August 2023

Des recherches archéologiques aériennes et sous-marines, menées à partir de 1975, ont permis de repérer une concentration de stèles funéraires et d’autels antiques par 4 à 5 m de profondeur au centre de l’anse Saint-Gervais, à Fos-sur-Mer. Vingt monuments ont été remontés entre 1975 et 1977, puis un dernier en 1994. Parmi eux, cinq stèles inscrites jettent un éclairage nouveau, quoique furtif, sur la population cosmopolite qui fréquenta le port antique au moment de sa pleine activité. L’étude des éléments lapidaires, couplée à celle des archives de fouilles, ainsi qu’une reprise des recherches de terrain à travers deux campagnes de prospection acoustique suivies de deux journées de prospection à vue, permettent de proposer une première synthèse des connaissances sur ce gisement dont la nature exacte reste encore incertaine : nécropole submergée ou blocs de réemploi ?
M. (?) Aurelius Cupitianus, le centurion oublié de Narbonne
Authors: Simelon Paul
Published: August 2023

Publication of a Roman epitaph (St-Paul’s Church-Narbonne).
Évolution des paysages et réflexion sur les modalités d’exploitation des sols
Authors: Bonnet Stéphane , Magnin Frédéric , Aujaleu Ariane
Published: August 2023

L’exploration du sous-sol des hauteurs d’Aix-en-Provence, sur l’emprise du centre hospitalier, à l’occasion de deux fouilles préventives, a mis au jour un paléo-vallon dont le colmatage enregistre l’évolution des milieux et de leur anthropisation depuis le Néolithique ancien. La reconstitution de cette histoire discontinue conduit à discuter le modèle du changement des paysages au cours de l’Holocène, anciennement établi pour la Provence. Cette étude se concentre sur l’Antiquité, et plus précisément le Haut Empire, afin d’affiner et d’enrichir, à l’aide des données sédimentologique et malacologique, la compréhension de l’occupation agraire de ce secteur présentée dans le second volet de cette étude dans l’article d’Ariane Aujaleu (ce volume).
Le chapiteau figuré de Javols-Anderitum (Lozère, France) : une composition ornementale singulière
Authors: Robert Renaud , Seigne J , Tardy Dominique , Ferdière Alain
Published: August 2023

The production of a digital cast of the upper register of the Corinthian capital of the Javols pilaster, known as the “ capital of Cybele”, has not only provided important information on the morphology of this incomplete piece of architecture, but has also allowed us to re-examine the identification of the axial scene depicted. The recognition of griffins in the two protomes led to the identification of a singular pattern resulting from the contamination of two themes of imperial iconography, for an important monument of this provincial civitas.
Nouvel examen d’une partie du trésor monétaire romain (terminus 312 apr. J.-C.) découvert en 1961 à Saint-Vincent-de-Mercuze, Isère
Authors: Cahanier Simon , Toussaint Jean-Jacques
Published: August 2023

Le trésor de Saint-Vincent-de-Mercuze III, découvert fortuitement en 1961, appartient à la catégorie des trésors mixtes mêlant antoniniens et aureliani radiés antérieurs à la réforme de 294 et nummi postérieurs. Sa chronologie s’étend du règne de Gallien à celui de Constantin et son terminus peut être fixé en 312 apr. J. ‑C., ce qui le fait entrer dans une catégorie peu représentée de dépôts monétaires tétrarchiques et invite à placer son enfouissement dans le contexte des suites de la bataille du pont Milvius, en octobre 312, et de la réforme monétaire de 313. Le catalogue publié en 1961 présente des erreurs qui justifient le réexamen et la nouvelle publication des cent soixante et une monnaies appartenant à une partie récemment redécouverte du dépôt ou conservées dans les collections publiques.
Psychological features of physical perfectionism in personality
Authors: Babchuk Mykyta Igorovich , Babchuk Olena Grigoriivna , Asieieva Yuliia , Vdovichenko Oksana , Melnychuk Iryna
Published: August 2023

The article examines the psychological features of physical perfectionism in personality. Physical perfectionism refers to a system of personal beliefs and attitudes related to one's physical appearance: heightened preoccupation with one's appearance and the pursuit of high body standards, striving for the best results in the pursuit of an ideal figure, as well as a pathological attitude towards any critical remarks about one's appearance. The formation of the «I-physical image» is influenced by socio-psychological factors and represents a dual process. On the one hand, it is the influence of society expressed in judgments, thoughts, perceptions, stereotypes, and ideals. On the other hand, it is the independent reflection and awareness of one's own criteria of body significance. The aim of the study is to determine the individual psychological characteristics of individuals with different levels of physical perfectionism. The object of study is the physical perfectionism of personality. The following methods were chosen to achieve the goal: theoretical-methodological analysis, psychodiagnostic, and mathematical-statistical methods. The psychodiagnostic complex consisted of the methods: «Physical Perfectionism Scale» and «I - Structural Test of the Ammon». The main task was to study the psychological characteristics of individuals with different levels of physical perfectionism. The conducted correlation analysis allowed us to identify significant relationships between indicators of physical perfectionism and indicators of «I-functions». Using the «axes» method, two groups of individuals with high and low levels of physical perfectionism were selected from the general group. In order to identify individual psychological characteristics, a qualitative analysis of property profiles in the corresponding groups was carried out. The obtained results of our study allow providing a psychological characterization of individuals who differ in the level of physical perfectionism and considering them as individuals endowed with a complex of personality traits that accompany a set of pronounced «I-functions».
Benchmarking in the logistics management system of Ukrainian enterprises
Authors: Zrybnieva Iryna , Pichugina Julia , Sigaieva Tetiana , Saienko Volodymyr , Korolkov Vladyslav
Published: August 2023

The relevance of this study is manifested in the need of Ukrainian logistics companies to effectively manage and increase their competitiveness. Establishing benchmark enterprises and applying benchmarking allows identifying best practices and management principles. The use of statistical data on the economic and economic activity of the logistics industry allowed for statistical, parametric and correlation analyzes, which contributes to an objective study of trends in the transport and logistics industry of Ukraine. The proposed hypothesis on the use of a wide sample of statistical data reflects the potential for developing an algorithm and implementing the benchmarking methodology in the logistics industry management system. It is found that motor transport enterprises occupy leading positions in the Ukrainian market of transport and logistics services. Freight and logistics services, in particular transportation of ore products, prevail in the field of motor transport. The analysis of regional peculiarities revealed that Dnipropetrovska oblast, Kyiv and Donetsk oblast are favorable for freight and logistics activities. It was also found that privately owned companies predominate among the specialized enterprises in this industry. The benchmarking analysis confirmed that it is possible to use profile data to identify benchmark enterprises with the best economic performance and to use their experience to improve the competitiveness of other companies. Such analysis reveals the strengths and weaknesses of enterprises, provides opportunities for improvement and development, and facilitates informed decision-making to improve the productivity and quality of logistics processes. Thus, the benchmarking methodology proves to be an effective tool for assessing and comparing the economic and financial performance of logistics companies, contributing to their competitiveness and market position.
The image of water in the Ukrainian postmodern novel
Authors: Pecherskyh Lubov , Levchenko Nataliia , Torkut Nataliia , Boiko Svitlana , Khhaacturian Karine
Published: August 2023

The purpose of the article is to define and systematize the artistic features and functions of water images on the material of Ukrainian postmodernist novels, in particular, in the novels “Twelve Hoops”, “Moscovyada” and “Radio Night” by Yu. Andrukhovych, “Mesopotamia” and “Voroshylovgrad” by S. Zhadan, “AMtm” by Yu. Izdryk, “Tango of Death” and “Lutetsia” by Yu. Vynnychuk. The authors trace how artistic and figurative codes rooted in the oldest layers of Ukrainian culture are transformed into author’s models of the image of water, which are subject to the artistic purpose of the novels, combine with other images, form more complex image combinations, and fulfill artistic tasks on the verge of artistic genres. The similarities and differences in the use of water images in a number of novels are revealed. The images of the river, the sea and water as element and substance are interpreted as frequently used, multilayered, multifunctional, multigenre and those that create a genre accent of mysticism in the novels, actualize mythological levels of perception of the depicted, emphasize the connection with the otherworldly and transcendent, manifest the extraordinary abilities of the person interacting with it and testify to the possibility of endowing with these properties, of being a trans-level means of moving through the worlds and a source of life.
Psychology of personality consciousness in the context of information and communication technologies and education system reform: Experience of EU countries
Authors: Iskakova Mira , Junissova Ainura , Kaldygozova Sandugash , Shafranskyi Volodymyr , Shakenova Maigul
Published: August 2023

The purpose of the article is to analyze the processes of formation of the psychology of personality consciousness in the context of active use of information and communication technologies and transformations in the field of education, primarily in the countries of the European Union. To realize this goal, the methods of analysis, synthesis, comparison, as well as axiological and systematic methods as elements of general scientific knowledge are used. The results of the study indicate that the use of ICTs can be useful for developing countries that are implementing the westernization of educational systems, including the Republic of Kazakhstan. The use of various interactive platforms, online courses, multimedia materials, and other digital tools contributes to the creation of multifaceted and meaningful learning environments that promote critical thinking, independence, and innovative abilities of students. It is also proved that the availability of information and its accessibility still do not guarantee the formation of knowledge at the personal level. The conclusions indicate that in order to optimize the use of ICT in the modern educational process, it is proposed to introduce artificial intelligence and develop in-depth digital competence among teachers.
Tra lingua, metodo e selezione dei modelli: il rapporto tra scrittura teologica e ricerca dell’unità nel pensiero di Jean Gerson
Authors: Micali Luciano
Published: August 2023

La ricerca dell’unità in ambito dottrinale, specchio e strumento dell’unità della Chiesa, è un elemento ricorrente nell’opera di Jean Gerson (1363-1429), rinomato teologo e cancelliere dell’Università di Parigi a cavallo tra il XIV ed il XV secolo. L’insistenza sul concetto di unità è veicolata da una costante riflessione sul ruolo e sui modi della scrittura teologica. Gerson individua precisi metodi e modelli da seguire al fine di spiegare alcune oscurità delle Scritture con chiarezza e precisione e senza rischi per l’integrità della dottrina. Parte fondamentale della riflessione sulla scrittura teologica è la discussione sulla possibilità di usare le lingue volgari, una possibilità che il cancelliere parigino nega in maniera lapidaria, stigmatizzando la confusione linguistica che inevitabilmente conduce non solo all’incomprensione reciproca, ma alla rottura di una corrispondenza tra termini e concetti che affonda le proprie radici in una consolidata e plurisecolare tradizione teologica in latino. Il presente articolo si propone di studiare la riflessione di Gerson sulla lingua, sui metodi e sulla selezione dei modelli nell’ambito della scrittura teologica accademica, nel quadro più ampio della ricerca dell’unità in ambito dottrinale, elemento necessario per perseguire l’unità della Chiesa tout court.
Impaired Spatial Firing Representations of Neurons in the Medial Entorhinal Cortex of the Epileptic Rat Using Microelectrode Arrays
Authors: Xu Zhaojie , Mo Fan , Yang Gucheng , Fan Penghui , Lu Botao , Liang Wei , Kong Fanli , Jing Luyi , Xu Wei , Liu Juntao , Wang Mixia , Wu Yirong , Cai Xinxia
Published: August 2023

Epilepsy severely impairs the cognitive behavior of patients. It remains unclear whether epilepsy-induced cognitive impairment is associated with neuronal activities in the medial entorhinal cortex (MEC), a region known for its involvement in spatial cognition. To explore this neural mechanism, we recorded the spikes and local field potentials from MEC neurons in lithium–pilocarpine-induced epileptic rats using self-designed microelectrode arrays. Through the open field test, we identified spatial cells exhibiting spatially selective firing properties and assessed their spatial representations in relation to the progression of epilepsy. Meanwhile, we analyzed theta oscillations and theta modulation in both excitatory and inhibitory neurons. Furthermore, we used a novel object recognition test to evaluate changes in spatial cognitive ability of epileptic rats. After the epilepsy modeling, the spatial tuning of various types of spatial cells had suffered a rapid and pronounced damage during the latent period (1 to 5 d). Subsequently, the firing characteristics and theta oscillations were impaired. In the chronic period (>10 d), the performance in the novel object experiment deteriorated. In conclusion, our study demonstrates the detrimental effect on spatial representations and electrophysiological properties of MEC neurons in the epileptic latency, suggesting the potential use of these changes as a “functional biomarker” for predicting cognitive impairment caused by epilepsy.
DEPENDENCE ON CHEMICAL INDUSTRY PRODUCTS MADE FROM OIL AND GAS – ON THE WAY TO THE ANNIHILATION OF HUMANITY
Authors: Szarek Stanisław
Published: August 2023

The study presents the consequences of economy’s dependence on chemical industry products made from oil and gas. It is reported that the economy is becoming increasingly dependent on the specified products. Based on the NACE Rev2 classification, the author lists the possible implications for all sectors of the economy of the cutting-off of the supplies of chemical industry products made from oil and gas It is demonstrated that the major consequences of the shortage of such products will be borne by agriculture, health protection, transport, automotive industry and construction. The paper lists the oil and gas processing products which are strategic in terms of the economy. The absence of the products may create a global economic crisis and make human development regress by 250 years.
Markers of Angiogenesis in Patients with Psoriasis
Authors: Брынина А.В. , Маркевич Е.Б. , Хворик Д.Ф.
Published: August 2023

Цель. Изучить содержание маркеров ангиогенеза в сыворотке крови у пациентов с псориазом и определить их взаимосвязь с формой и стадией дерматоза. Материалы и методы. Обследовано 90 пациентов, находившихся на лечении в ГУЗ «Гродненский областной клинический кожно-венерологический диспансер». Результаты. Проведен анализ уровня маркеров активации эндотелия в сыворотке крови: медиана содержания sVCAM нг/мл и VEFG пг/мл у обследованных пациентов с псориазом составила 139,8 нг/мл (112; 227,9) и 87,1 пг/мл (50,9; 166,7) соответственно. При сравнительной оценке содержания sVCAM-1 и VEGF в сыворотке крови в зависимости от формы и стадии псориаза достоверных различий не установлено. При расчете коэффициента корреляции Спирмена были получены следующие данные: выявлена умеренная корреляция между содержанием VEGF пг/мл и ДИКЖ (r=0,35), а также корреляция между содержанием sVCAM нг/мл и значениями индексов PASI и ДИКЖ (r=0,57 и 0,41 соответственно). Заключение. Маркеры активации эндотелия играют значимую роль в патогенезе псориаза, достоверных различий в зависимости от стадии и формы заболевания установлено не было, однако выявлены умеренно значимые корреляции между содержанием маркеров ангиогенеза и индексом PASI, а также дерматологическим индексом качества жизни.

Purpose. To study the content of angiogenesis markers in the blood serum of patients with psoriasis and determine their relationship with the form and stage of dermatosis. Materials and methods. The study involved 90 patients who were treated at the Grodno Regional Clinical Dermatovenerologic Dispensary. Results. The level of markers of endothelial activation in blood serum was analyzed: the median content of sVCAM ng/ml and VEFG pg/ml in examined patients with psoriasis was 139.8 ng/ml (112; 227.9) and 87.1 pg/ml (50.9; 166.7), respectively. When comparing the content of sVCAM-1 and VEGF in blood serum, depending on the form and stage of psoriasis, no significant differences were found. When calculating the Spearman correlation coefficient, the following data were obtained: a moderate correlation was found between the content of VEGF pg/ml and dermatological quality of life index (r=0.35), as well as a correlation between the content of sVCAM ng/ml and the values of the PASI and dermatological quality of life index indices (r=0.57 and 0.41, respectively). Conclusion. Endothelial activation markers play a significant role in the pathogenesis of psoriasis, no significant differences depending on the stage and form of the disease were found, however, moderately significant correlations were found between the content of angiogenesis markers and the PASI index, as well as the dermatological quality of life index.
Pyoderma Gangrenosum: A Clinical Case
Authors: Тимошенко В.А. , Крук Н.И. , Шиманская И.Г.
Published: August 2023

Гангренозная пиодермия относится к нейтрофильным дерматозам – группе редких заболеваний кожи, характеризующейся неконтролируемыми процессами пролиферации и миграции нейтрофилов в кожу. В статье приводится клинический случай хронического, тяжелого, торпидного ко многим видам лечения дерматоза, который представляет интерес в связи с редкостью данного заболевания.

Pyoderma gangrenosum belongs to neutrophilic dermatoses, a group of rare skin diseases characterized by uncontrolled proliferation and migration of neutrophils into the skin. A clinical case of chronic, severe, torpid to many types of treatment dermatosis is presented, which is of interest due to the rarity of this disease.