bluuebunny/crossref_metadata_2025 huggingface dataset:
Indigenous standpoint theory as a theoretical framework for decolonizing social science health research with American Indian communities
Authors: Cox Genevieve R , FireMoon Paula , Anastario Michael P , Ricker Adriann , Escarcega-Growing Thunder Ramey , Baldwin Julie A , Rink Elizabeth
Published: August 2021

Theoretical frameworks rooted in Western knowledge claims utilized for public health research in the social sciences are not inclusive of American Indian communities. Developed by Indigenous researchers, Indigenous standpoint theory builds from and moves beyond Western theoretical frameworks. We argue that using Indigenous standpoint theory in partnership with American Indian communities works to decolonize research related to American Indian health in the social sciences and combats the effects of colonization in three ways. First, Indigenous standpoint theory aids in interpreting how the intersections unique to American Indians including the effects of colonization, tribal and other identities, and cultural context are linked to structural inequalities for American Indian communities. Second, Indigenous standpoint theory integrates Indigenous ways of knowing with Western research orientations and methodologies in a collaborative process that works to decolonize social science research for American Indians. Third, Indigenous standpoint theory promotes direct application of research benefits to American Indian communities.
Return-to-Sport Time and Postoperative Performance in MLB Players Undergoing Wrist Arthroscopy
Authors: Orozco Erin I. , Guloy Andrea E. , Cotton Michael O. , Jack Robert A. , Liberman Shari R.
Published: August 2021

Background:

Wrist injuries are common in sports and can result in prolonged time missed from playing. This study aimed to determine in Major League Baseball-players after arthroscopic wrist surgery the return-to-sport (RTS) rate, postoperative career length, and changes in performance compared with preoperative statistics and matched controls.

Methods:

Major League Baseball players who underwent arthroscopic wrist surgery from 1990 to 2019 were identified. Demographic and performance data were collected for each player, and matched controls were identified. Comparisons were made via paired samples Student t tests.

Results:

Twenty-six players (27 surgeries) were identified. The average age of included players was 28.9 ± 2.9 years with an average professional experience of 5.2 ± 3.4 years. Eighty-four percent of players returned to sport, with an average RTS time of 5.0 ± 2.7 months. A statistically significant ( P < .05) decrease was seen in preoperative and postoperative runs scored per season (95.6 ± 91.3 vs 41.0 ± 29.5), batting average (BA) (0.270 ± 0.024 vs 0.240 ± 0.036), and average wins above replacement (WAR) (1.5 ± 1.1 vs 0.8 ± 0.9).

Conclusion:

Major League Baseball players who underwent arthroscopic wrist surgery had an RTS rate of 84% at a mean time of 5.0 months. There was no significant difference in performance statistics between cases postoperatively and matched controls overall, with some differences in performance found when categorized by position. However, a significant decrease in performance among case players was observed between preoperative and postoperative performance, including runs per season, BA, and WAR.
Prevalence of CYP2C19 and ITGB3 polymorphisms among Bangladeshi patients who underwent percutaneous coronary intervention
Authors: Islam Md Rabiul , Nova Tasnova Tasnim , Momenuzzaman NAM , Rabbi Sikder Nahidul Islam , Jahan Ishrat , Binder Thomas , Islam Mohammad Safiqul , Hasnat Abul , Nahar Zabun
Published: August 2021

Introduction:

Antithrombotic agents are the basic therapeutic option for patients with arterial thrombosis who underwent percutaneous coronary intervention (PCI). In Bangladesh, aspirin and clopidogrel are frequently prescribed as antithrombotics or platelet inhibitors. Studies reported the genetic polymorphisms of CYP2C19*2, CYP2C19*17, and ITGB3 cause an alteration of the pharmacodynamic and pharmacokinetic profile of aspirin and clopidogrel. Therefore, we aimed to assess the prevalence of CYP2C19*2, CYP2C19*17, and ITGB3 polymorphisms among Bangladeshi patients with cardiovascular disease (CVD) who underwent PCI.

Methods:

Here we assessed a total of 1,000 CVD patients (male 782 and female 218) who underwent PCI and were treated with clopidogrel and/or aspirin. We performed genotyping of patients treated with clopidogrel and aspirin by polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) and tetra-primer amplification refractory mutation system PCR (T-ARMS-PCR) methods. The PCR products of clopidogrel-treated patients were screened with agarose gel electrophoresis and then digested with SmaI and NsiI-HF for CYP2C19*2 and CYP2C19*17, respectively. We genotyped aspirin-treated patients with T-ARMS-PCR for missense rs5918 (PlA1/A1) polymorphism of the ITGB3 gene. Then we ran the digested PCR products on 2% agarose gel electrophoresis to detect the mentioned polymorphisms.

Results:

Among the clopidogrel-treated patients, we observed 64.1% polymorphism (hetero + mutant) of CYP2C19*2 (loss-of-function allele) and 22.7% (hetero + mutant) of CYP2C19*17 (gain-of-function allele). On the other hand, among the aspirin-treated patients, polymorphisms of ITGB3 were 84.1% homozygous (PlA1/A1), 15.6% heterozygous (PlA1/A2), and 0.3% mutant homozygous.

Conclusion:

In the present study, we observed a high prevalence of genetic polymorphisms of CYP2C19 and ITGB3 genes. Therefore, we recommend genotyping of CVD patients before prescribing clopidogrel or aspirin to prevent coagulation. Based on the genotyping study, the adjustment of doses or alternative generics might require to avoid therapeutic failure or toxicity in some cases.
GIS-Based Analysis Framework to Identify the Determinants of COVID-19 Incidence and Fatality in Africa
Authors: Hassaan Mahmoud A. , Abdelwahab Rofida G. , Elbarky Toka A. , Ghazy Ramy Mohamed
Published: August 2021

Corona virus diseases 2019 (COVID-19) pandemic is an extraordinary threat with significant implications in all aspects of human life; therefore, it represents the most immediate challenge for the countries all over the world. This study, hence, is intended to identify the best GIS-based model that can explore, quantify, and model the determinants of COVID-19 incidence and fatality. For this purpose, geospatial models were developed to estimate COVID-19 incidence and fatality rates in Africa, up to 16th of August 2020 at the national level. The models involved Ordinary Least Squares (OLS) and Geographically Weighted Regression (GWR) analysis using ArcGIS. Spatial autocorrelation analysis recorded a positive spatial autocorrelation in COVID-19 incidence (Moran index 0.16, P = 0.1) and fatality (Moran index 0.26, P = 0.01) rates within different African countries. GWR model had higher R2 than OLS for prediction of incidence and mortality (58% vs 45% and 55% vs 53%). The main predictors of COVID-19 incidence rate were overcrowding, health expenditure, HIV infections, air pollution, and BCG vaccination (mean β = 3.10, 1.66, 0.01, 3.79, and −66.60 respectively, P < 0.05). The main determinants of COVID-19 fatality were prevalence of bronchial asthma, tobacco use, poverty, aging, and cardiovascular diseases fatality (mean β = 0.00162, 0.00004, −0.00025, −0.00144, and −0.00027 respectively, P < 0.05). Application of the suggested model can assist in guiding intervention strategies, particularly at the local and community level whenever the data on COVID-19 cases and predictors variables are available.
Student Retention in School Bands and Orchestras: A Literature Review
Authors: Hash Phillip M.
Published: August 2021

The purpose of this review was to synthesize the literature on attrition and retention in instrumental music and to identify strategies to encourage students’ continued participation in school bands and orchestras. Retaining members from 1 year to the next is a key factor in building ensembles and helping individual musicians reach their full potential. At least 35 years of research, however, has yielded little consistency in determining why students persist in or dropout of instrumental study. Most decisions likely involve (a) practical considerations, especially related to scheduling and other interests and commitments; (b) students’ attitudes on their musicianship and various aspects of the program; and (c) the influence of other people. The MUSICSM Model of Motivation can provide a framework through which stakeholders examine how their school bands and orchestras meet the needs of students, thus influencing their decisions to leave or remain in the program.
Monitor for lactate in perspiration
Authors: Luo Ting-Ting , Sun Zhong-Hai , Li Chu-Xin , Feng Jin-Lian , Xiao Zhao-Xiu , Li Wei-Dong
Published: August 2021

Sweat is a noninvasive biological fluid on the surface of human skin and has attracted increasing attention as a diagnostic specimen for disease and biomarker detection. Sweat metabolite quantification is possible due to progress in sweat analysis techniques; nevertheless, the role of sweat monitoring in energy metabolism, physiological or pathological state assessment, health status assessment, and the development and outcome of metabolism-related diseases remains unclear. This review provides a comprehensive overview of the literature on human sweat lactate concentration. The first, second, and third sections of this review present an introduction of sweat lactate, methods for the collection and storage of sweat lactate samples, and methods of detection and analysis of sweat lactate, respectively. The fourth section elaborates upon the current state of clinical application of sweat lactate monitoring and its prospects for health surveillance. The last section focuses on the challenges and future directions of this novel technology for detecting lactate in sweat.
Psychological distress among Ethiopian migrant returnees who were in quarantine in the context of COVID-19: institution-based cross-sectional study
Authors: Habtamu Kassahun , Desie Yekoyealem , Asnake Mulat , Lera Endirias Gina , Mequanint Temesgen
Published: August 2021

Background

In association with the novel coronavirus (SARS-CoV-2) disease 2019 (COVID-19) pandemic, many numbers of Ethiopian migrants are returning to their home country, and they are required to stay in mandatory quarantine centers. This results in severe disruptions of life routines, social isolation, and loss of freedom. Studies on psychological distress among Ethiopian migrant returnees in the context of COVID-19 are scarce. This study aimed to investigate the prevalence of psychological distress and associated factors among migrant returnees who were in quarantine during the time of COVID-19.

Methods

A cross-sectional study was conducted with 405 migrant returnees recruited from quarantine centers in Addis Ababa. We developed a structured questionnaire to collect data on sociodemographic, migration related, quarantine related and COVID-19 related characteristics of participants. We used the 21 item Depression, Anxiety and Stress Scale to assess psychological distress. Univariate and multivariable negative binomial regression models were fitted to assess the association between exposure variables with depression, anxiety and stress separately.

Results

A little more than half of the participants (55%) had depressive symptoms; around half had anxiety symptoms (48.9%) and more than a third (35.6%) experienced symptoms of stress. We found significantly higher prevalence of anxiety (ARR = 0.59; 95% CI = 0.39, 0.91) and depressive symptoms (ARR = 0.56; 95% CI = 0.39, 0.81) among women than men. Fear of discrimination after the quarantine was significantly associated with depressive (ARR = 0.76; 95% CI = 0.63, 0.92) and anxiety symptoms (ARR = 0.77; 95% CI = 0.62, 0.97). Experiencing COVID-19 like symptoms is associated with depressive (ARR = 0.40; 95% CI = 0.25, 0.65), anxiety (ARR = 0.35; 95% CI = 0.20, 0.62) and stress symptoms (ARR = 0.43; 95% CI = 0.28, 0.66). Have no a plan of what to do after the quarantine (ARR = 1.30; 95% CI = 1.09, 1.54) was significantly associated with increasing stress scores.

Conclusions

We found a very high prevalence of depressive, anxiety and stress symptoms among Ethiopian migrant returnees who were in quarantine due to the COVID-19 pandemic. Screening, integration of mental health services with other socioeconomic and psychosocial services, and effective and efficient referral may be useful to address the burden of psychological distress in this group.
Socio-economic differences in the uptake of HIV testing and associated factors in South Africa
Authors: Jooste Sean , Mabaso Musawenkosi , Taylor Myra , North Alicia , Shean Yolande , Simbayi Leickness Chisamu
Published: August 2021

Background

Improved understanding of barriers to HIV testing is important for reaching the first of the UNAIDS 90–90-90 targets, which states that 90% of HIV positive individuals ought to know their HIV status. This study examined socio-economic status (SES) differences in HIV testing uptake and associated factors among youth and adults 15 years and older in South Africa.

Methods

This study used data from a national cross-sectional, population-based household survey conducted in 2017 using a multi-stage sampling design. A composite SES score was created using multiple correspondence analyses of household assets; households were classified into wealth quintiles and dichotomised into low SES/poorest (lowest 3 quintiles) and high SES/less-poor (highest 2 quintiles). Bivariate and multivariate logistic regression models were used to examine factors associated with the uptake of HIV testing in low and high SES households.

Results

HIV testing uptake was 73.8 and 76.7% among low and high SES households, respectively, both of which were below the first 90 targets. Among both low and high SES households, increased HIV testing uptake was significantly associated with females than males. The decreased likelihood was significantly associated with residing in rural formal areas than urban areas, those with no education or low levels of educational attainment and alcohol drinkers among low SES households. Whites and Indians/Asians had a decreased likelihood than Black Africans in high SES households.

Conclusions

HIV testing interventions should target males, residents in rural formal areas, those with no or low education and those that consume alcohol in low SES households, including Whites and Indians/Asians from high SES households in order to bridge socio-economic disparities in the uptake of HIV testing. This should entail expanding HIV testing beyond traditional centres for voluntary counselling and testing through outreach efforts, including mobile testing and home-based testing.
Effect of different visual presentations on the comprehension of prognostic information: a systematic review
Authors: Abukmail Eman , Bakhit Mina , Del Mar Chris , Hoffmann Tammy
Published: August 2021

Background

Understanding prognostic information can help patients know what may happen to their health over time and make informed decisions. However, communicating prognostic information well can be challenging.

Purpose

To conduct a systematic review to identify and synthesize research that has evaluated visual presentations that communicate quantitative prognostic information to patients or the public.

Data sources

MEDLINE, EMBASE, CINAHL,PsycINFO, ERIC and the Cochrane Central Register of Controlled Trials (CENTRAL) (from inception to December 2020), and forward and backward citation search.

Study selection

Two authors independently screened search results and assessed eligibility. To be eligible, studies required a quantitative design and comparison of at least one visual presentation with another presentation of quantitative prognostic information. The primary outcome was comprehension of the presented information. Secondary outcomes were preferences for or satisfaction with the presentations viewed, and behavioral intentions.

Data extraction

Two authors independently assessed risk of bias and extracted data.

Data synthesis

Eleven studies (all randomized trials) were identified. We grouped studies according to the presentation type evaluated. Bar graph versus pictograph (3 studies): no difference in comprehension between the groups. Survival vs mortality curves (2 studies): no difference in one study; higher comprehension in survival curve group in another study. Tabular format versus pictograph (4 studies): 2 studies reported similar comprehension between groups; 2 found higher comprehension in pictograph groups. Tabular versus free text (3 studies): 2 studies found no difference between groups; 1 found higher comprehension in a tabular group.

Limitations

Heterogeneity in the visual presentations and outcome measures, precluding meta-analysis.

Conclusions

No visual presentation appears to be consistently superior to communicate quantitative prognostic information.
Expression profiles and functional prediction of long non-coding RNAs LINC01133, ZEB1-AS1 and ABHD11-AS1 in the luminal subtype of breast cancer
Authors: Mehrpour Layeghi Sepideh , Arabpour Maedeh , Shakoori Abbas , Naghizadeh Mohammad Mehdi , Mansoori Yaser , Tavakkoly Bazzaz Javad , Esmaeili Rezvan
Published: August 2021

Background

Luminal breast cancer (BC) is the most frequent subtype accounting for more than 70% of BC. LncRNAs, a class of non-coding RNAs with more than 200 nucleotides, are involved in a variety of cellular processes and biological functions. Abberant expression is related to the development of various cancers, such as breast cancer. LINC01133, ZEB1-AS1, and ABHD11-AS1 were reported to be dysregulated in different cancers. However, their expression level in luminal BC remains poorly known. The aim of the present study was to evaluate the potential roles of these lncRNAs in BC, especially in luminal subtypes.

Methods

A comprehensive analysis was performed using the Lnc2Cancer database to identify novel cancer-associated lncRNA candidates. After conducting a literature review, three novel lncRNAs named LINC01133, ZEB1-AS1, and ABHD11-AS1 were chosen as target genes of the present study. Quantitative real‐time polymerase chain reaction (qRT-PCR) was used to evaluate the expression level of the mentioned lncRNAs in both luminal BC tissues and cell lines. Then, the correlation of the three mentioned lncRNAs expression with clinicopathological characteristics of the patients was studied. Moreover, several datasets were used to discover the potential roles and functions of LINC01133, ZEB1-AS1 and ABHD11-AS1 in luminal subtype of BC.

Results

According to the qRT-PCR assay, the expression levels of LINC01133 and ZEB1-AS1 were decreased in luminal BC tissues and cell lines. On the other hand, ABHD11-AS1 was upregulated in the above-mentioned samples. The expression levels of LINC01133, ZEB1-AS1, and ABHD11-AS1 were not associated with any of the clinical features. Also, the results obtained from the bioinformatics analyses were consistent with qRT-PCR data. Functional annotation of the co-expressed genes with the target lncRNAs, protein–protein interactions and significantly enriched Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways across luminal BC were also obtained using bioinformatics analysis.

Conclusions

Taken together, our findings disclosed the dysregulation of LINC01133, ZEB1-AS1, and ABHD11-AS1 in luminal BC. It was revealed that LINC01133 and ZEB1-AS1 expression was significantly downregulated in luminal BC tissues and cell lines, while ABHD11-AS1 was upregulated considerably in the mentioned tissues and cell lines. Also, bioinformatics and systems biology analyses have helped to identify the possible role of these lncRNAs in luminal BC. However, further analysis is needed to confirm the current findings.
SLC7A11 regulated by NRF2 modulates esophageal squamous cell carcinoma radiosensitivity by inhibiting ferroptosis
Authors: Feng Lei , Zhao Kaikai , Sun Liangchao , Yin Xiaoyang , Zhang Junpeng , Liu Conghe , Li Baosheng
Published: August 2021

Background

Solute carrier family 7 member 11(SLC7A11) is a component of cysteine/glutamate transporter, which plays a key role in tumor growth; however, its underlying effect on radiosensitivity in esophageal squamous cell carcinoma (ESCC) remains unclear. This study aimed to clarify SLC7A11’s expression and correlation with nuclear expression of nuclear factor erythroid-2(NRF2)-associated radioresistance in ESCC.

Methods

We included 127 ESCC patients who received radical chemoradiotherapy. Immunohistochemical staining was used to detect SLC7A11 and NRF2 nuclear expression, and the relationship between clinicopathological characteristics and survival rates or therapy response were evaluated. Western blot, dual-reporter assays and Chromatin immunoprecipitation (ChIP)-sequencing were used to analyze their relationship in vitro. Their roles in radioresistance were then investigated through multiple validation steps.

Results

NRF2 nuclear expression and SLC7A11 expression were overexpressed in ESCC tissues and were positively correlated with one another. NRF2 nuclear expression was significantly associated with tumor length, lymph node metastasis, and TNM stage, while SLC7A11 expression was associated with lymph node metastasis. Patients with high NRF2 nuclear expression and SLC7A11 expression had significantly shorter overall and progression-free survival, and poor treatment response. The multivariate model showed that NRF2 nuclear expression and SLC7A11 expression, sex and tumor location are independent prognostic factors. In vitro analysis confirmed that hyperactivation of NRF2 induced SLC7A11 expression by directly binding to its promoter region, promoting radioresistance, reducing radiotherapy-induced lipid peroxidation levels, PTGS2 expression, and radiotherapy-related ferroptosis morphologic features.

Conclusion

Our study reveals a connection between high SLC7A11 expression and NRF2 nuclear expression in patients with ESCC that was related to worse survival and poorer therapy outcomes. SLC7A11-mediated ferroptosis inhibition induced NRF2-associated radioresistance, highlighting potential of NRF2/SLC7A11/ferroptosis axis as future therapeutic targets against therapy resistance biomarker.
First characterization of toxic alkaloids and volatile organic compounds (VOCs) in the cryptic dendrobatid Silverstoneia punctiventris
Authors: Gonzalez Mabel , Palacios-Rodriguez Pablo , Hernandez-Restrepo Jack , González-Santoro Marco , Amézquita Adolfo , Brunetti Andrés E. , Carazzone Chiara
Published: August 2021

Background

Poison frogs are known for the outstanding diversity of alkaloid-based chemical defences with promising therapeutic applications. However, current knowledge about chemical defences in Dendrobatoidea superfamily has two sources of bias. First, cryptic, brown-colored species have been neglected in comparison to those conspicuously colored, and second, there has been little interest in characterizing metabolites other than alkaloids mediating defensive functions. In an effort to contribute to fill the gap of knowledge about cryptic species and broadening the spectrum of compounds analyzed we have applied head-space solid phase microextraction coupled to gas chromatography and mass spectrometry (HS-SPME/GC-MS) for extracting amphibian alkaloids and volatile organic compounds (VOCs) from Silverstoneia punctiventris.

Results

Using the skin from 8 specimens in 4 biological replicates we have found 33 different compounds. Twenty of them were classified as VOCs into 15 chemical classes including alkanes, alcohols, carbonyl compounds, methylpyridines, benzothiazoles, N-alkylpyrrolidines, pyrazines, and sesquiterpenoids, some of which were previously reported as repellents, defence compounds or defence pheromones in other organisms, and as sex pheromones in a treefrog. Interestingly, six of the remaining compounds were identified as alkaloids previously reported in other toxic/unpalatable dendrobatid frogs.

Conclusions

This is the first report of alkaloids and VOCs found in the Silverstoneia genus, which has been assumed for decades as non-chemically defended. This study establishes HS-SPME/GC-MS as a new application for a simultaneous approach to amphibian alkaloids and VOCs in poison frogs while opens up new research questions to assess the co-occurrence of both type of compounds and to investigate the evolutionary significance of a defence gradient that includes olfactory avoidance, unpalatability, and toxicity in dendrobatids. In addition, our results show that amphibian alkaloids could have a dual function (olfactory at distance, taste by contact) never explored before neither in Silverstonaeia nor in any other dendrobatid species.
Research as usual in humanitarian settings? Equalising power in academic-NGO research partnerships through co-production
Authors: Lokot Michelle , Wake Caitlin
Published: August 2021

Background

Research partnerships in conflict-affected and humanitarian settings can reveal complex power hierarchies between academics and NGOs. During the process of research, decision-making may skew in favour of more powerful actors, who often direct the scope of the research, hold the budget and lead the analysis. Co-production is increasingly emerging as a helpful approach that attempts to equalise power dynamics during research. The aim of this paper is to draw attention to the main challenges associated with a “research as usual” approach to research partnerships in humanitarian settings, as power hierarchies may be particularly magnified in these settings.

Methods

This paper is based on a comprehensive literature review and 32 semi-structured interviews with academics and practitioners from non-government organisations. Participants were selected purposively based on their experience in co-producing research or working within research partnerships. Some participants had worked in humanitarian settings while others had experience co-producing research in non-humanitarian contexts. We used Nvivo to thematically code data.

Results

This paper documents the problems with “research as usual” partnerships in humanitarian settings, specifically: the burden on communities as merely sources of data, certain forms of knowledge being valued over others, lack of reflection on the power hierarchies structuring research partnerships, top-down decision-making and lack of transparency, one-way “capacity-building”, lack of mutual benefit, and rigid research processes and timeframes.

Conclusion

This paper highlights key challenges with standard research practices in humanitarian settings and identifies seven key principles of co-production that can be helpful in attempting to equalise power dynamics within research partnerships, specifically in conflict-affected and humanitarian settings.
Changes in self-efficacy in Japanese school-age children with and without high autistic traits after the Universal Unified Prevention Program: a single-group pilot study
Authors: Oka Takuya , Ishikawa Shin-ichi , Saito Aya , Maruo Kazushi , Stickley Andrew , Watanabe Norio , Sasamori Hiroki , Shioiri Toshiki , Kamio Yoko
Published: August 2021

Background

Research has shown the efficacy of school-based programs for mental health problems in children. However, few studies have focused on the strengths of children, such as resilience, which is essential in preventing mental health problems. Moreover, no research has investigated the effect of a universal school-based program on children with increased autistic traits in mainstream classes. We examined the changes in children's self-efficacy, social skills, and general mental health after the implementation of a newly developed universal program, the Universal Unified Prevention Program for Diverse Disorders (Up2-D2), and whether similar changes occurred in children with and without higher autistic traits.

Methods

To assess possible changes associated with the program, questionnaires were collected from 396 children (207 boys and 189 girls) aged 9–12 years old before (T1), immediately after (T2), and three months after (T3) the implementation of the program.

Results

Results from a linear mixed-effects model showed a significant increase in children's self-efficacy at T2 (adjusted difference 0.49, 95% CI 0.03–0.94; p < 0.05) and T3 (0.78, 95% CI 0.32–1.23; p < 0.001). There were also significant positive changes in social skills and general mental health. Similar changes were observed in children with high autistic traits. Autistic traits at T1 did not contribute to the degree of change in self-efficacy.

Conclusions

Our pilot study suggests that a universal program has the potential to promote positive attitudes and mental health in both at-risk and not-at-risk children.
Existence of solutions for a class of Kirchhoff-type equations with indefinite potential
Authors: Zhou Jian , Wu Yunshun
Published: August 2021

In this paper, we consider the existence of solutions of the following Kirchhoff-type problem: $$\begin{aligned} \textstyle\begin{cases} - (a+b\int _{\mathbb{R}^{3}} \vert \nabla u \vert ^{2}\,dx )\Delta u+ V(x)u=f(x,u) , & \text{in }\mathbb{R}^{3}, \\ u\in H^{1}(\mathbb{R}^{3}),\end{cases}\displaystyle \end{aligned}$$

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+
b

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2

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3

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where $a,b>0$
a
,
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are constants, and the potential $V(x)$
V
(
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is indefinite in sign. Under some suitable assumptions on f, the existence of solutions is obtained by Morse theory.
Small peptide-based GLP-1R ligands: an approach to reduce the kidney uptake of radiolabeled GLP-1R-targeting agents?
Authors: Felber Veronika Barbara , Wester Hans-Jürgen
Published: August 2021

Aim

Elevated kidney uptake in insulinoma patients remains a major limitation of radiometallated exendin-derived ligands of the glucagon-like peptide 1 receptor (GLP-1R). Based on the previously published potent GLP-1R-activating undecapeptide 1, short-chained GLP-1R ligands were developed to investigate whether kidney uptake can be reduced by means of direct 18F-labeling (nuclide-based accelerated renal excretion) or the reduction of the overall ligand charge (ligand-based reduced kidney uptake).

Materials & methods

GLP-1R ligands were prepared according to optimized standard protocols via solid-phase peptide synthesis (SPPS) or, when not practicable, via fragment coupling in solution. Synthesis of (2‘-Et, 4‘-OMe)4, 4’-L-biphenylalanine ((2′-Et, 4′-OMe)BIP), required for the preparation of 1, was accomplished by Suzuki-Miyaura cross-coupling. In vitro experiments were performed using stably transfected GLP-1R+ HEK293-hGLP-1R cells.

Results

In contrast to the three reference ligands glucagon-like peptide 1 (GLP-1, IC50 = 23.2 ± 12.2 nM), [Nle14, Tyr(3-I)40]exendin-4 (IC50 = 7.63 ± 2.78 nM) and [Nle14, Tyr40]exendin-4 (IC50 = 9.87 ± 1.82 nM), the investigated GLP-1R-targeting small peptides (9–15 amino acids), including lead peptide 1, exhibited only medium to low affinities (IC50 > 189 nM). Only SiFA-tagged undecapeptide 5 (IC50 = 189 ± 35 nM) revealed a higher affinity than 1 (IC50 = 669 ± 242 nM).

Conclusion

The investigated small peptides, including lead peptide 1, could not compete with favorable in vitro characteristics of glucagon-like peptide 1 (GLP-1), [Nle14, Tyr(3-I)40]exendin-4 and [Nle14, Tyr40]exendin-4. The auspicious EC50 values of 1 provided by the literature could not be transferred to competitive binding experiments. Therefore, the use of 1 as a basic scaffold for the design of further GLP-1R-targeting radioligands cannot be recommended. Further investigations might include the scaffold of 5, although substantial optimizations concerning affinity and lipophilicity would be required. In sum, GLP-1R-targeting radioligands with reduced kidney uptake could not be obtained in this work, which emphasizes the need for further ligands addressing this particular issue.
A bio-environmental perspective on Emirati female college students’ experiences in virtual learning communities of inquiry
Authors: AlShamsi Aysha Saeed
Published: August 2021

During the coronavirus pandemic, educational institutions were forced to shift to virtual learning. Drawing on the Community of Inquiry framework and bioecological perspective, this research explores the virtual learning experiences of female college students at one higher education institution in the United Arab Emirates using an interpretive phenomenological paradigm. A convergent parallel mixed method design was implemented with participants (N = 350) who completed a questionnaire about the challenges of virtual learning followed by semi-structured interviews (N = 10). Observations, journals, and peer-reviewed literature was also used to explore the influence of cognitive, social, and teaching presence on students’ perceptions. The data were analyzed using descriptive statistics and thematic analysis. The researcher found students had a high perception of the three influences of Community of Inquiry framework and were aware of its importance. Furthermore, there were clear relationships between cognitive and teaching presence and cognitive and social presence. The importance of online teaching and learning strategies supports the interactivity of these presences.
On the efficiency of entomopathogenic nematodes (Rhabditida: Heterorhabditidae and Steinernematidae) on rust red flour beetle, Tribolium castaneum (Herbst.) (Coleoptera: Tenebrionidae)
Authors: Erdoğuş Fatma Dolunay
Published: August 2021

Background

The rust red flour beetle, Tribolium castaneum (Herbst.) (Coleoptera: Tenebrionidae) is a serious pest of stored grains and grain products across the world. This beetle is hold a significant place in Turkey by causing damages on stored products. T. castaneum primarily attacks milled grain and its derivates. Entomopathogenic nematodes (EPNs) are regarded as extremely an important biological control agent. EPNs kills their hosts within 48 h by the bacteria they carry.

Results

Efficacies of 4 isolates of EPNs Steinernema carpocapsae (Tokat Bakisli 05), S. feltiae (Tokat-Emir), Heterorhabditis bacteriophora (TOK-20) and H. bacteriophora (11-KG) against T. castaneum was investigated under laboratory conditions. The experiments were carried out thrice with 10 replicates at 2 different temperatures (15 and 25 ºC). EPNs isolates were tested at 3 different concentrations (250, 500 and 1000 IJs/ml) with a pure water as control. The overall mortality caused by H. bacteriophora (Kg11) was significantly higher than the other EPN species. At 25 ºC, H. bacteriophora (Kg11) at the highest concentration (1000 IJs/ml) caused 87.6% mortality after 120 h., followed by S. carpocapsae and S. feltiae with 79.22 and 75.3% mortality rates, respectively. The mortality percentages exhibited by all nematodes’ species at both temperatures were lowest at the concentration of (250 IJs/ml). At 15 °C, H. bacteriophora (Kg11) caused (55.2%) mortality rate at the highest concentration (1000 IJs / ml) after 120 h.

Conclusion

The study suggested that these nematodes were efficient and could be recommended to control T. castaneum in its biological control programs.
Ethical and Analytic Challenges With Genomic Sequencing of Relapsed Hematologic Malignancies Following Allogeneic Hematopoietic Stem-Cell Transplantation
Authors: Marwa Bilal , Krueger Joerg , Stephenson Elizabeth A. , Davidson Scott , Allan David , Knoppers Bartha , Zawati Ma'n , Sullivan Patrick , Shlien Adam , Malkin David , Fernandez Conrad V. , Villani Anita
Published: August 2021

The implementation of precision medicine and next-generation sequencing technologies in the field of oncology is a novel approach being more widely studied and used in cases of high-risk primary and recurrent malignancies. Leukemias are the second most common cause of cancer-related mortality in children and the sixth most in adults. Relapsed leukemia represents a major component of the population that may benefit from genomic sequencing. However, ethical and analytic challenges arise when considering sequencing of biologic samples obtained from patients with relapsed leukemia following allogeneic hematopoietic stem-cell transplantation. Blood from the recipient after transplantation would include donor-derived cells and thus, genomic sequencing of recipient blood will interrogate the donor germline in addition to the somatic genetic profile of the leukemia cells and the recipient germline. This is a situation for which the donor will not have typically provided consent and may be particularly problematic if actionable secondary or incidental findings related to the donor are uncovered. We present the challenges raised in this scenario and provide strategies to mitigate this risk.
Days of the Cavemen? Adorno, Spengler, and the Anatomy of Caesarism
Authors: Immanen Mikko
Published: August 2021

This article addresses the controversial question of Theodor W. Adorno’s debt to right-wing Zivilisationskritik by a close reading of his essay “Spengler after the Decline” (1950). The article shows that despite Adorno’s harsh polemics against Oswald Spengler’s Decline of the West (1918, 1922), he sought to make Spengler’s analysis of Weimar Germany’s undemocratic tendencies—“Caesarism”—serve progressive ends. However, Adorno’s essay was not just an effort at “coming to terms with the past” in Adenauerian West Germany. Reading the essay’s original 1941 version together with Adorno’s correspondence with Max Horkheimer sheds light on Spengler as an overlooked key (next to Max Weber, Sigmund Freud, and Walter Benjamin) to their Dialectic of Enlightenment, written in 1941–44. Adorno’s daring effort to appropriate Spengler’s analysis of Caesarism makes Adorno’s critical theory an asset in understanding today’s authoritarian populism.
On Anson Rabinbach’s Staging the Third Reich
Authors: Aschheim Steven E.
Published: August 2021

This article presents an exposition, analysis, and critique of Anson Rabinbach’s historical research and theses as reflected in Staging the Third Reich: Essays in Cultural and Intellectual History (2020), a volume of his essays on Nazism, fascism, antifascism, and the aftermath of these movements in political life, public remembrance, and historiography. The article probes Rabinbach’s particular method and significant contributions to intellectual and cultural history.
The kinetics of E-selectin- and P-selectin-induced intermediate activation of integrin αLβ2 on neutrophils
Authors: Zhou Fangyuan , Zhang Fang , Zarnitsyna Veronika I. , Doudy Larissa , Yuan Zhou , Li Kaitao , McEver Rodger P. , Lu Hang , Zhu Cheng
Published: August 2021

Selectins and integrins are key players in the adhesion and signaling cascade that recruits leukocytes to inflamed tissues. Selectin binding induces β2 integrin binding to slow leukocyte rolling. Here, a micropipette was used to characterize neutrophil adhesion to E-selectin and intercellular adhesion molecule-1 (ICAM-1) at room temperature. The time-dependent adhesion frequency displayed two-stage kinetics, with an E-selectin-mediated fast increase to a low plateau followed by a slow increase to a high plateau mediated by intermediate-affinity binding of integrin αLβ2 to ICAM-1. The αLβ2 activation required more than 5 s contact to E-selectin and spleen tyrosine kinase (Syk) activity. A multi-zone channel was used to analyze αLβ2 activation by P-selectin in separate zones of receptors or antibodies, finding an inverse relationship between the rolling velocity on ICAM-1 and P-selectin dose, and a P-selectin dose-dependent change from bent to extended conformations with a closed headpiece that was faster at 37°C than at room temperature. Activation of αLβ2 exhibited different levels of cooperativity and persistent times depending on the strength and duration of selectin stimulation. These results define the precise timing and kinetics of intermediate activation of αLβ2 by E- and P-selectins.
The small GTPase KlRho5 responds to oxidative stress and affects cytokinesis
Authors: Musielak Marius , Sterk Carolin C. , Schubert Felix , Meyer Christian , Paululat Achim , Heinisch Jürgen J.
Published: August 2021

Rho5 is the yeast homolog of the human small GTPase Rac1. We characterized the genes encoding Rho5 and the subunits of its dimeric activating guanine-nucleotide-exchange factor (GEF), Dck1 and Lmo1, in the yeast Kluyveromyces lactis. Rapid translocation of the three GFP-tagged components to mitochondria upon oxidative stress and carbon starvation indicate a similar function of KlRho5 in energy metabolism and mitochondrial dynamics as described for its Saccharomyces cerevisiae homolog. Accordingly, Klrho5 deletion mutants are hyper-resistant towards hydrogen peroxide. Moreover, synthetic lethalities of rho5 deletions with key components in nutrient sensing, such as sch9 and gpr1, are not conserved in K. lactis. Instead, Klrho5 deletion mutants display morphological defects with strengthened lateral cell walls and protruding bud scars. The latter result from aberrant cytokinesis, as observed by following the budding process in vivo and by transmission electron microscopy of the bud neck region. This phenotype can be suppressed by KlCDC42G12V, which encodes a hyper-active variant. Data from live-cell fluorescence microscopy support the notion that KlRho5 interferes with the actin moiety of the contractile actomyosin ring, with consequences different from those previously reported for mutants lacking myosin.
Analyzing normal and disrupted leukemic stem cell adhesion to bone marrow stromal cells by single-molecule tracking nanoscopy
Authors: Gorshkova Oksana , Cappaï Jessica , Maillot Loriane , Sergé Arnauld
Published: August 2021

Leukemic stem cells (LSCs) adhere to bone niches through adhesion molecules. These interactions, which are deeply reorganized in tumors, contribute to LSC resistance to chemotherapy and leukemia relapse. However, LSC adhesion mechanisms and potential therapeutic disruption using blocking antibodies remain largely unknown. Junctional adhesion molecule C (JAM-C, also known as JAM3) overexpression by LSCs correlates with increased leukemia severity, and thus constitutes a putative therapeutic target. Here, we took advantage of the ability of nanoscopy to detect single molecules with nanometric accuracy to characterize junctional adhesion molecule (JAM) dynamics at leuko-stromal contacts. Videonanoscopy trajectories were reconstructed using our dedicated multi-target tracing algorithm, pipelined with dual-color analyses (MTT2col). JAM-C expressed by LSCs engaged in transient interactions with JAM-B (also known as JAM2) expressed by stromal cells. JAM recruitment and colocalization at cell contacts were proportional to JAM-C level and reduced by a blocking anti-JAM-C antibody. MTT2col revealed, at single-molecule resolution, the ability of blocking antibodies to destabilize LSC binding to their niches, opening opportunities for disrupting LSC resistance mechanisms.
ΠΡΟΒΛΗΜΑΤΑ ΣΥΝΤΟΝΙΣΜΟΥ ΤΑΥΤΟΧΡΟΝΩΝ ΠΡΟΣΠΕΛΑΣΕΩΝ ΣΕ ΒΑΣΕΙΣ ΔΕΔΟΜΕΝΩΝ
Authors: Χατζηλάκος Αθανάσιος
Published: August 2021

ΣΤΗ ΔΙΑΤΡΙΒΗ ΑΥΤΗ ΜΕΛΕΤΟΥΜΕ ΠΡΟΒΛΗΜΑΤΑ ΣΥΝΤΟΝΙΣΜΟΥ ΤΑΥΤΟΧΡΟΝΩΝ ΠΡΟΣΠΕΛΑΣΕΩΝ ΣΕΒΑΣΕΙΣ ΔΕΔΟΜΕΝΩΝ. ΟΙ ΣΥΝΤΟΝΙΣΤΕΣ ΜΕ ΑΝΤΙΓΡΑΦΑ ΕΙΝΑΙ ΗΔΗ ΕΝΑΣ ΠΛΑΤΙΑ ΑΠΟΔΕΚΤΟΣΜΗΧΑΝΙΣΜΟΣ ΓΙΑ ΒΕΛΤΙΩΣΗ ΤΗΣ ΑΠΟΔΟΣΗΣ ΤΟΥ ΣΥΝΤΟΝΙΣΜΟΥ. ΣΤΟ ΚΕΦΑΛΑΙΟ 2 ΤΗΣ ΔΙΑΤΡΙΒΗΣ ΕΙΣΑΓΟΥΜΕ ΜΙΑ ΝΕΑ ΕΝΝΟΙΑ ΣΕΙΡΙΟΠΟΙΗΣΙΜΟΤΗΤΑΣ ΜΕ ΑΝΤΙΓΡΑΦΑ (MVSR) ΠΟΥ ΒΑΣΙΖΕΤΑΙ ΣΤΗΝ ΕΝΝΟΙΑ ΤΗΣ ΑΝΤΙΘΕΣΗΣ (MVCSR) ΚΑΙ ΜΕΛΕΤΟΥΜΕ ΤΗ ΣΧΕΣΗ ΤΗΣ ΜΕ ΤΗΝ ΚΛΑΣΣΙΚΗ ΕΝΝΟΙΑ ΤΗΣ ΑΝΤΙΘΕΣΗΣ ΧΩΡΙΣ ΑΝΤΙΓΡΑΦΑ (CSR). ΑΠΟΔΕΙΚΝΥΟΥΜΕ ΟΤΙ ΤΟ ΠΡΟΒΛΗΜΑ ΤΟΥ ΑΝ ΕΝΑ ΣΥΝΟΛΟ ΧΡΟΝΙΚΩΝ ΕΙΝΑΙ ΕΠΙΤΟΠΟΥ ΣΥΝΤΟΝΙΣΙΜΟ (ΕΤΣ) ΕΙΝΑΙ ΠΛΗΡΕΣ ΣΤΟΝΡ. ΕΙΣΑΓΟΥΜΕ ΤΗΝ ΕΝΝΟΙΑ ΤΩΝ ΜΕΓΙΣΤΩΝ ΕΤΣ ΣΥΝΟΛΩΝ ΧΡΟΝΙΚΩΝ ΚΑΙ ΑΠΟΔΕΙΚΝΥΟΥΜΕΟΤΙ ΕΙΝΑΙ ΑΔΥΝΑΤΗ Η ΚΑΤΑΣΚΕΥΗ ΑΠΟΔΟΤΙΚΩΝ ΣΥΝΤΟΝΙΣΤΩΝ ΠΟΥ ΝΑ ΑΝΑΓΝΩΡΙΖΟΥΝ ΜΕΓΙΣΤΑ ΕΤΣ ΥΠΟΣΥΝΟΛΑ ΤΟΥ MVSR # ΤΟΥ MVCSR. ΤΕΛΟΣ ΠΑΡΟΥΣΙΑΖΟΥΜΕ ΕΝΑ ΓΕΝΙΚΟ ΑΛΓΟΡΙΘΜΙΚΟ ΠΛΑΙΣΙΟ ΓΙΑ ΣΥΝΤΟΝΙΣΤΕΣ MVCSR. ΣΤΟ 3 ΚΕΦΑΛΑΙΟ ΛΥΝΟΥΜΕ ΤΟ ΠΡΟΒΛΗΜΑ ΤΟΥ ΚΛΕΙΣΙΜΑΤΟΣ ΔΟΣΟΛΗΨΙΩΝ ΓΙΑ ΤΟ ΓΝΩΣΤΟ ΣΥΝΤΟΝΙΣΤΗ ΓΡΑΦΟΥ ΑΝΤΙΘΕΣΕΩΝ. ΤΟ ΠΡΟΒΛΗΜΑ ΕΙΝΑΙ: ΠΟΤΕ ΜΠΟΡΕΙ ΝΑ ΔΙΑΓΡΑΦΕΙ ΕΝΑΣ ΚΟΜΒΟΣ ΑΦΟΥ Η ΑΝΤΙΣΤΟΙΧΗ ΔΟΣΟΛΗΨΙΑ ΕΧΕΙ ΟΛΟΚΛΗΡΩΘΕΙ; ΒΡΙΣΚΟΥΜΕ ΜΙΑ ΑΝΑΓΚΑΙΑ ΚΑΙ ΙΚΑΝΗ ΣΥΝΘΗΚΗ ΓΙ'ΑΥΤΟ. ΜΕΛΕΤΟΥΜΕ ΤΟ ΔΥΝΑΜΙΚΟ ΠΡΟΒΛΗΜΑ ΤΗΣ ΚΑΤΕΠΑΝΑΛΗΨΗ ΔΙΑΓΡΑΦΗΣ ΚΟΜΒΩΝ ΟΣΟ ΠΡΟΧΩΡΕΙ ΤΟ ΧΡΟΝΙΚΟ ΚΑΙ ΜΕΛΕΤΟΥΜΕ ΤΟ ΠΡΟΒΛΗΜΑ ΤΟΥ ΚΛΕΙΣΙΜΑΤΟΣ ΓΙΑ ΟΡΙΣΜΕΝΕΣ ΠΑΡΑΛΛΑΓΕΣ ΤΟΥ ΜΟΝΤΕΛΟΥ ΤΩΝ ΔΟΣΟΛΗΨΙΩΝ.
ΠΡΟΙΣΤΟΡΙΚΗ ΘΑΣΟΣ Ι: ΤΑ ΝΕΚΡΟΤΑΦΕΙΑ ΤΟΥ ΟΙΚΙΣΜΟΥ "ΚΑΣΤΡΙ"
Authors: Κουκούλη-Χρυσανθάκη Χάιδω
Published: August 2021

ΣΤΗ ΔΙΑΤΡΙΒΗ ΣΥΓΚΕΝΤΡΩΝΕΤΑΙ ΤΟ ΑΡΧΑΙΟΛΟΓΙΚΟ ΥΛΙΚΟ, ΠΟΥ ΟΙ ΠΡΟΣΦΑΤΕΣ ΑΝΑΣΚΑΦΙΚΕΣ ΚΑΙ ΠΡΟΑΝΑΣΚΑΦΙΚΕΣ ΕΡΕΥΝΕΣ ΕΧΟΥΝ ΣΥΓΚΕΝΤΡΩΣΕΙ ΓΙΑ ΤΗΝ ΠΡΩΤΟΙΣΤΟΡΙΚΗ ΠΕΡΙΟΔΟ ΤΗΣ ΘΑΣΟΥ, ΤΗΝ ΕΠΟΧΗ ΔΗΛΑΔΗ ΠΟΥ ΜΕΣΟΛΑΒΕΙ ΑΝΑΜΕΣΑ ΣΤΟ ΤΕΛΟΣ ΤΟΥ ΜΥΚΗΝΑΙΚΟΥ ΚΟΣΜΟΥ ΚΑΙ ΤΗΝ ΕΞΑΦΑΝΙΣΗ ΤΟΥ ΑΠΟ ΤΟ ΒΟΡΕΙΟ ΑΙΓΑΙΟ ΚΑΙ ΣΤΗΝ ΑΡΧΗ ΤΟΥ Β' ΜΕΓΑΛΟΥ ΕΛΛΗΝΙΚΟΥ ΑΠΟΙΚΙΣΜΟΥ ΣΤΟ ΒΟΡΕΙΟ ΑΙΓΑΙΟ. (1300-700 Π.Χ.). ΒΑΣΙΚΗ ΑΦΕΤΗΡΙΑ ΓΙΑ ΤΗΝΕΡΕΥΝΑ ΑΠΟΤΕΛΕΙ ΤΟ ΑΡΧΑΙΟΛΟΓΙΚΟ ΥΛΙΚΟ ΑΠΟ ΤΗΝ ΑΝΑΣΚΑΦΗ ΤΩΝ ΝΕΚΡΟΤΑΦΕΙΩΝ ΤΟΥ ΟΙΚΙΣΜΟΥ "ΚΑΣΤΡΙ" ΣΤΗ ΝΟΤΙΑ ΘΑΣΟ, ΤΑ ΟΠΟΙΑ ΧΡΟΝΟΛΟΓΟΥΝΤΑΙ ΣΤΑ ΤΕΛΗ ΤΗΣ ΥΣΤΕΡΗΣ ΕΠΟΧΗΣ ΧΑΛΚΟΥ ΚΑΙ ΣΤΗΝ ΠΡΩΙΜΗ ΕΠΟΧΗ ΤΟΥ ΣΙΔΗΡΟΥ. ΜΕΤΑ ΤΗ ΛΕΠΤΟΜΕΡΕΙΑΚΗ ΠΕΡΙΓΡΑΦΗ ΤΗΣ ΑΝΑΣΚΑΦΗΣ ΚΑΙ ΤΩΝ ΕΥΡΗΜΑΤΩΝ ΤΩΝ ΠΑΡΑΠΑΝΩ ΝΕΚΡΟΤΑΦΕΙΩΝ ΕΠΙΧΕΙΡΕΙΤΑΙ ΜΕ ΒΑΣΗ ΤΟ ΥΠΑΡΧΟΝ ΑΡΧΑΙΟΛΟΓΙΚΟ ΥΛΙΚΟ Η ΑΝΑΣΥΝΘΕΣΗ ΤΗΣ ΠΟΛΙΤΙΣΤΙΚΗΣ ΦΥΣΙΟΓΝΩΜΙΑΣ ΤΗΣ ΘΑΣΟΥ ΣΤΗΝ ΠΡΩΤΟΙΣΤΟΡΙΚΗ ΠΕΡΙΟΔΟ ΚΑΙ Ο ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΤΩΝ ΠΟΛΙΤΙΣΤΙΚΩΝ ΣΧΕΣΕΩΝ ΤΗΣ ΜΕ ΤΟ ΑΙΓΑΙΟ, ΤΗΝ ΜΑΚΕΔΟΝΙΑ, ΤΗ ΘΡΑΚΗ ΚΑΙ ΤΑ ΗΠΕΙΡΩΤΙΚΑ ΒΑΛΚΑΝΙΑ. ΙΔΙΑΙΤΕΡΟΙ ΠΟΛΙΤΙΣΤΙΚΟΙ ΧΩΡΟΙ ΠΟΥ ΕΡΕΥΝΩΝΤΑΙ ΕΙΝΑΙ Η ΟΙΚΟΝΟΜΙΚΗ ΚΑΙ ΚΟΙΝΩΝΙΚΗ ΟΡΓΑΝΩΣΗ ΤΩΝ ΠΡΩΤΟΙΣΤΟΡΙΚΩΝ ΟΙΚΙΣΜΩΝ ΤΗΣ ΘΑΣΟΥ ΚΑΙ ΟΙ ΠΑΡΑΓΩΓΙΚΕΣ ΔΡΑΣΤΗΡΙΟΤΗΤΕΣ ΤΟΥ ΠΛΗΘΥΣΜΟΥ ΤΟΥ ΝΗΣΙΟΥ ΠΡΙΝ ΑΠΟ ΤΗΝ ΑΦΙΞΗ ΤΩΝ ΠΑΡΙΩΝ ΑΠΟΙΚΩΝ ΣΤΙΣ ΑΡΧΕΣ ΤΟΥ 7ΟΥ Π.Χ. ΑΙΩΝΑ (ΓΕΩΡΓΙΑ, ΚΤΗΝΟΤΡΟΦΙΑ, ΜΕΤΑΛΛΟΥΡΓΙΑ, ΑΓΓΕΙΟΠΛΑΣΤΙΚΗ, ΕΜΠΟΡΙΟ ΚΛΠ).
Η ΕΛΛΗΝΙΚΗ ΕΚΣΤΡΑΤΕΙΑ ΣΤΗ ΜΙΚΡΑ ΑΣΙΑ ΚΑΙ Η ΣΤΑΣΗ ΤΩΝ ΙΝΔΩΝ ΜΟΥΣΟΥΛΜΑΝΩΝ 1918-1922
Authors: Munir Ahmad
Published: August 2021

ΟΙ ΕΛΛΗΝΙΚΕΣ ΔΙΕΚΔΙΚΗΣΕΙΣ ΣΤΟ ΤΕΛΟΣ ΤΟΥ Α' ΠΑΓΚΟΣΜΙΟΥ ΠΟΛΕΜΟΥ ΣΥΝΕΧΙΣΑΝ ΜΕ ΤΗΝΚΙΝΗΤΟΠΟΙΗΣΗ ΤΩΝ ΜΟΥΣΟΥΛΜΑΝΩΝ ΤΗΣ ΙΝΔΙΑΣ ΥΠΕΡ ΤΗΣ ΑΚΕΡΑΙΟΤΗΤΑΣ ΤΗΣ ΕΠΙΚΡΑΤΕΙΑΣ ΤΟΥ ΣΟΥΛΤΑΝΟΥ ΚΑΙ ΧΑΛΙΦΗ, ΚΙΝΗΤΟΠΟΙΗΣΗ ΓΝΩΣΤΗ ΩΣ "ΚΙΝΗΣΗ ΤΟΥ ΧΑΛΙΦΑΤΟΥ". ΣΤΗΝ ΙΝΔΙΑ ΘΕΩΡΗΘΗΚΕ ΟΤΙ Η ΜΕΓΑΛΗ ΒΡΕΤΑΝΙΑ ΗΤΑΝ Ο ΚΑΤΕΞΟΧΗΝ ΥΠΟΣΤΗΡΙΚΤΗΣ ΤΩΝ ΣΧΕΔΙΩΝ ΔΙΑΜΕΛΙΣΜΟΥ ΤΗΣ ΟΘΩΜΑΝΙΚΗΣ ΑΥΤΟΚΡΑΤΟΡΙΑΣ. ΕΤΣΙ, ΟΙ ΜΕΤΑΠΟΛΕΜΙΚΕΣ ΕΞΕΛΙΞΕΙΣ, ΑΠΟ ΤΗΝ ΑΝΑΚΩΧΗ ΤΟΥ ΜΟΥΔΡΟΥ ΩΣ ΤΗ ΣΥΝΘΗΚΗ ΤΩΝ ΣΕΡΒΩΝ (10 ΑΥΓΟΥΣΤΟΥ 1920) ΚΑΤΕΣΤΗΣΑΝ ΤΟΥΣ ΙΝΔΟΥΣ ΜΟΥΣΟΥΛΜΑΝΟΥΣ ΕΞΑΙΡΕΤΙΚΑ ΚΑΧΥΠΟΠΤΟΥΣ ΑΠΕΝΑΝΤΙ ΣΤΗ ΒΡΕΤΑΝΙΚΗ ΚΥΒΕΡΝΗΣΗ ΚΑΙ ΑΠΡΟΚΑΛΥΠΤΑ ΕΧΘΡΙΚΟΥΣ ΑΠΕΝΑΝΤΙ ΣΤΙΣ ΕΛΛΗΝΙΚΕΣ ΠΡΟΣΠΑΘΕΙΕΣ ΓΙΑΤΗΝ ΕΝΣΩΜΑΤΩΣΗ ΤΗΣ ΑΝ. ΘΡΑΚΗΣ ΚΑΙ ΤΗΣ ΙΩΝΙΑΣ ΣΤΗΝ ΕΛΛΑΔΑ. ΑΠΟ ΤΗΝ ΑΛΛΗ ΜΕΡΙΑ ΟΙ ΕΘΝΙΚΙΣΤΕΣ ΙΝΔΟΙΣΤΕΣ, ΣΥΜΠΕΡΙΛΑΜΒΑΝΟΜΕΝΟΥ ΤΟΥ GANDHI, ΕΣΠΕΥΣΑΝ ΝΑ ΥΠΟΣΤΗΡΙΞΟΥΝ ΤΗΝ ΚΙΝΗΣΗ ΤΟΥ KHILAFAT ΓΙΑ ΠΟΛΙΤΙΚΟΥΣ ΛΟΓΟΥΣ. Η ΕΚΤΑΣΗ ΤΗΣ ΚΙΝΗΣΗΣ ΠΡΟΞΕΝΗΣΕ ΑΝΗΣΥΧΙΕΣ ΣΤΗΝ ΒΡΕΤΑΝΟ-ΙΝΔΙΚΗ ΚΥΒΕΡΝΗΣΗ ΚΑΙ ΕΝΑΥΣΜΑ ΓΙΑ ΝΑ ΑΛΛΑΞΕΙ ΤΗ ΣΤΑΣΗ ΤΗΣ ΠΡΟΣ ΤΗΝ ΤΟΥΡΚΙΑ. ΟΙ ΠΙΕΣΕΙΣ ΑΠ'ΤΟΥΣ ΙΝΔΟΥΣ ΜΟΥΣΟΥΛΜΑΝΟΥΣ ΠΟΥ ΑΡΧΙΣΑΝ ΑΠ'ΤΗΝ ΕΠΟΜΕΝΗ ΚΙΟΛΑΣ ΤΗΣ ΑΝΑΚΩΧΗΣ ΤΟΥ ΜΟΥΔΡΟΥ, ΚΟΡΥΦΩΘΗΚΑΝ ΚΑΤΑ ΤΗΝ ΠΕΡΙΟΔΟ ΤΩΝ ΕΠΙΧΕΙΡΗΣΕΩΝ ΣΤΟ ΕΣΩΤΕΡΙΚΟ ΤΗΣ ΜΙΚΡΑΣ ΑΣΙΑΣ. ΟΙ ΣΥΝΕΠΕΙΕΣ ΑΥΤΩΝ ΤΩΝ ΠΙΕΣΕΩΝ ΗΤΑΝ ΝΑ ΕΝΙΣΧΥΟΥΝ ΟΙ ΙΝΔΟΙ ΤΟΥΣ ΤΟΥΡΚΟΥΣ ΕΘΝΙΚΙΣΤΕΣ ΚΑΙ ΝΑ ΑΠΟΤΡΕΠΟΥΝ ΤΗΝ ΜΕΓΑΛΗ ΒΡΕΤΑΝΙΑ ΝΑ ΕΚΠΛΗΡΩΣΕΙ ΤΙΣ ΣΥΜΜΑΧΙΚΕΣ ΤΗΣ ΥΠΟΧΡΕΩΣΕΙΣ ΑΠΕΝΑΝΤΙ ΣΤΟΥΣ ΜΑΧΟΜΕΝΟΥΣ ΕΛΛΗΝΕΣ. ΣΤΗΝ ΕΡΓΑΣΙΑ ΠΟΥ ΕΙΝΑΙ ΒΑΣΙΣΜΕΝΗ ΣΕ ΑΝΕΚΔΟΤΟ ΚΥΡΙΩΣ ΒΡΕΤΑΝΙΚΟ ΚΑΙ ΙΝΔΙΚΟ ΥΛΙΚΟ- ΑΝΑΛΥΕΤΑΙ ΔΙΕΞΟΔΙΚΑ ΤΟ ΖΗΤΗΜΑ ΚΙ ΕΚΤΙΜΟΥΝΤΑΙ ΟΙ ΣΥΝΕΠΕΙΕΣ ΤΟΥ ΚΙΝΗΜΑΤΟΣ KHILAFAT ΩΣ ΠΡΟΣ ΤΙΣ ΙΝΔΟ-ΒΡΕΤΑΝΙΚΕΣ ΣΧΕΣΕΙΣ ΚΙ ΩΣ ΠΡΟΣ ΤΗΝ ΕΞΕΛΙΞΗ ΚΑΙ ΤΡΑΓΙΚΗ ΚΑΤΑΛΗΞΗ ΤΗΣ ΕΛΛΗΝΙΚΗΣ ΠΕΡΙΠΕΤΕΙΑΣ ΣΤΗ ΜΙΚΡΑ ΑΣΙΑ.
ΕΚΤΙΜΗΣΗ ΤΗΣ ΣΥΜΒΟΛΗΣ ΤΟΥ ΞΥΛΟΥ ΣΤΗΝ ΠΕΡΙΦΕΡΕΙΑΚΗ ΑΝΑΠΤΥΞΗ ΜΕ ΠΟΣΟΤΙΚΕΣ ΜΕΘΟΔΟΥΣ
Authors: Σούτσας Κωνσταντίνος
Published: August 2021

Η ΕΡΓΑΣΙΑ ΑΥΤΗ ΑΣΧΟΛΕΙΤΑΙ ΜΕ ΤΗΝ ΠΕΡΙΓΡΑΦΗ ΚΑΙ ΑΝΑΛΥΣΗ ΤΩΝ ΓΕΝΙΚΩΝ ΘΕΩΡΗΤΙΚΩΝ ΑΡΧΩΝ ΤΗΣ ΠΕΡΙΦΕΡΕΙΑΚΗΣ ΑΝΑΠΤΥΞΗΣ, ΤΩΝ ΥΠΟΔΕΙΓΜΑΤΩΝ ΕΙΣΡΟΩΝ-ΕΚΡΟΩΝ, ΤΟΥ ΜΑΘΗΜΑΤΙΚΟΥ ΠΡΟΓΡΑΜΜΑΤΙΣΜΟΥ ΚΑΙ ΤΩΝ ΝΟΜΟΘΕΤΙΚΩΝ ΠΛΑΙΣΙΩΝ ΑΣΚΗΣΗΣ ΤΗΣ ΠΕΡΙΦΕΡΕΙΑΚΗΣ ΠΟΛΙΤΙΚΗΣ. ΑΥΤΑ ΑΠΟΤΕΛΟΥΝ ΤΟ ΥΠΟΒΑΘΡΟ ΓΙΑ ΤΗΝ ΚΑΤΑΣΚΕΥΗ ΥΠΟΔΕΙΓΜΑΤΩΝ ΕΙΣΡΟΩΝ -ΕΚΡΟΩΝ ΚΑΙ ΓΡΑΜΜΙΚΟΥ ΠΡΟΓΡΑΜΜΑΤΙΣΜΟΥ ΠΟΥ ΘΑ ΧΡΗΣΙΜΟΠΟΙΗΘΟΥΝ ΣΤΗΝ ΕΚΤΙΜΗΣΗ ΤΗΣ ΣΥΜΒΟΛΗΣ ΤΟΥ ΔΑΣΟΥΣ ΚΑΙ ΕΙΔΙΚΟΤΕΡΑ ΤΟΥ ΞΥΛΟΥ ΣΤΗΝ ΑΝΑΠΤΥΞΗ ΤΗΣ ΠΕΡΙΦΕΡΕΙΑΣ ΤΗΣ ΘΕΣΣΑΛΙΑΣ. ΕΙΔΙΚΟΤΕΡΑ ΕΞΕΤΑΖΕΤΑΙ Η ΣΥΝΕΙΣΦΟΡΑ ΤΩΝ ΒΙΟΤΕΧΝΙΩΝ ΚΑΙ ΒΙΟΜΗΧΑΝΙΩΝ ΤΟΥ ΞΥΛΟΥ ΤΗΣ ΕΝ ΛΟΓΩ ΠΕΡΙΦΕΡΕΙΑΣ ΣΤΟ ΕΙΣΟΔΗΜΑ ΤΩΝ ΕΡΓΑΖΟΜΕΝΩΝ ΣΤΟΥΣ ΥΠΟΨΗ ΤΟΜΕΙΣ, Η ΔΥΝΑΤΟΤΗΤΑ ΑΠΑΣΧΟΛΗΣΗΣ ΠΟΥ ΜΠΟΡΕΙ ΝΑ ΠΡΟΣΦΕΡΟΥΝ ΟΙ ΤΟΜΕΙΣ ΑΥΤΟΙ ΚΑΙ Η ΕΞΕΥΡΕΣΗ ΔΥΝΑΤΩΝ ΕΝΑΛΛΑΚΤΙΚΩΝ ΛΥΣΕΩΝ (ΠΡΟΤΑΣΕΩΝ) ΓΙΑ ΤΟΥΣ ΕΠΙΧΕΙΡΗΜΑΤΙΕΣ ΥΠΟ ΣΥΝΘΗΚΕΣ ΣΤΑΘΕΡΗΣ 'Η ΑΥΞΑΝΟΜΕΝΗΣ ΤΕΛΙΚΗΣ ΖΗΤΗΣΗΣ ΤΩΝ ΠΡΟΙΟΝΤΩΝ ΠΟΥ ΠΑΡΑΓΟΥΝ.