bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel cubical fuzzy score function for the location selection of wind farm using linear assignment method
Authors: A Thilagavathy , S Mohanaselvi
Published: February 2023

In an uncertain context, extensions of the fuzzy set have a substantial impact in multiple criteria decision making (MCDM) situations. Cubical fuzzy set (CFS), is one such extension that is more advantageous for handling impreciseness in MCDM problems. The comparison of cubical fuzzy numbers (CFNs) is a signicant stage in the cubical fuzzy decision making process. In literature, it is found that the existing ranking functions fails to compare CFNs in certain situations. In order to address this issue, the current paper focuses on dening a new score function that compares CFNs in all circumstances. A comparison study is made with the literature to show the potency of the proposed score function. In multiple criteria problems, nding criteria weights plays a vital phase during the decision making process. Taking into account, this paper adopted the subjective method of pairwise comparison for determining the criteria objective weights. Further, a cubical fuzzy linear assignment method (CF-LAM) based on the proposed score function for solving a cubical fuzzy multiple criteria group decision making (CF-MCGDM) problem has been developed. The practical applicability and feasibility of the proposed score function using the developed LAM are illustrated by solving a real life MCGDM problem of nding the best location for the construction of a wind power farm under a CF environment.
Cubic Fe-bearing majorite synthesized at 18-25 GPa and 1000 °C: implications for element transport, subducted slab rheology and diamond formation
Authors: Stagno Vincenzo , Bindi Luca , Bonechi Barbara , Greaux Steeve , Aulbach Sonja , Irifune Tetsuo , Lupi Stefano , Marras Giulia , McCammon Catherine A. , Nazzari Manuela , Piccirilli Federica , Poe Brent , Romano Claudia , Scarlato Piergiorgio
Published: February 2023

The chemistry and mineralogy of slabs subducted into lower mantle control slab rheology and impacts the deep volatile cycle. It is known that the metamorphism of little-altered oceanic crust results in eclogite rocks with subequal proportions of garnet and clinopyroxene. With increasing pressure, these minerals react to stabilize pyrope-rich tetragonal majoritic garnet. However, some eclogites contain higher proportions of omphacitic clinopyroxene, caused by Na- and Si-rich metasomatism on the ocean floor or during subduction. The mineralogy of such eclogites is expected to evolve differently. Here, we discuss the results of the crystallization products of omphacitic glass at ~18 and ~25 GPa and 1000 °C to simulate P-T regimes of cold subduction. The full characterization of the recovered samples indicates evidence of crystallization of Na-, Si-rich cubic instead of tetragonal majorite. This cubic majorite can incorporate large amounts of ferric iron, promoting redox reactions with surrounding volatile-bearing fluids and, ultimately, diamond formation. In addition, the occurrence of cubic majorite in the slab would affect the local density, favoring the continued buoyancy of the slab as previously proposed by seismic observations. Attention must be paid to omphacitic inclusions in sublithospheric diamonds as these might have experienced back-transformation from the HP isochemical cubic phase.
Experimental Study Of Steel Plate Girder With Innovative Shape Of Web Under Concentrated Load
Authors: Shaffaf Noora N. , Ammash Haider K.
Published: February 2023

The experimental investigation was presented in this paper and the laboratory tests was performed on I-girders with honeycomb steel plate web HWG. The objective of the research was to estimate the shear behavior of the honeycomb steel plate web girders that subjected to one-point loading. Twelve simply supported specimens with differences in the web corrugations were divided into four groups, first one is the flat web FW while the others are the honeycomb webs HW. The honeycomb web classified with respect to the width of honeycomb cell which included; 60, 80 and 100mm. Also, each group with three samples which fabricated with a variable aspect ratio a/d; 1, 2 and 3. Tested under one concentrated load applied at mid-span of simply-supported girder. The results showed that, the honeycomb web with 60mm-thick and with aspect ratio a/d equal to 1, recorded a highest value in the ultimate load compared with flat web and with other samples of honeycomb web. Also, it was concluded that, thickness of steel plate, and corrugation dimensions of honeycomb web had great effects on the enhancement of web shear resistance.
Survival Benefit and Cost-Effectiveness Analysis of a Future Blood-Based Diagnostic Test to Detect Cerebral Aneurysm Formation: A hypothetical modeling study
Authors: Mittal Aditya M. , Nowicki Kamil W. , Dembinski Robert , Alattar Ali , McDowell Michael M. , Lang Michael J. , Gross Bradley A. , Friedlander Robert M.
Published: February 2023

IMPORTANCE: Cerebral aneurysms are typically diagnosed incidentally or upon rupture.
In this study we aimed to investigate cost-effectiveness of a hypothetical blood-based diagnostic test to detect cerebral aneurysm formation in the US healthcare model.
DESIGN: Markov decision analytic models were created for four different case studies to simulate management of cerebral aneurysm diagnosis within the US healthcare system over 50 years. To assess robustness, we performed sensitivity analyses. Further analysis was performed for different risk factors, patient groups, and aneurysm size.
INTERVENTIONS: Standard care, thrice-annually blood test monitoring, annual blood testing among high-risk groups.
RESULTS: A blood based diagnostic test pathway is more cost effective in patients undergoing watchful-waiting and as a screening tool in patients at a higher-risk of developing an aneurysm when compared to the traditional pathway. Our analysis demonstrated a greater than three-fold reduction in mortality compared to the standard of care (SOC) (15.71% vs 53.10%, respectively). The cost of using a blood test per additional QALY gained was estimated to be $34,515.13 among the watchful-waiting cohort. The threshold price for cost-effectiveness of a blood test was determined to be $3,951. Among patients with one family member with an aneurysm and smokers, we observed a near tenfold reduction in mortality compared to the SOC (0.21% vs 2.35%, and 0.27% vs 3.30 %, respectively) with a threshold at $865.23 and $1,078.48.
CONCLUSIONS: Introduction of a hypothetical blood-based diagnostic test to detect cerebral aneurysm formation would have a life-saving effect within the US healthcare system while remaining cost-effective.
Ocimum kilimandscharicum 4CL11 negatively regulates root formation by inhibiting polar auxin transport via flavonoids accumulation
Authors: Lavhale Santosh , Kondhare Kirtikumar , Sinthadurai Veenothini , Barvkar Vitthal , Joshi Rakesh , Giri Ashok
Published: February 2023

4-Coumarate-CoA Ligase (4CL) is an important enzyme in the phenylpropanoid biosynthesis pathway. Multiple 4CLs are identified in Ocimum species; however, their function remains enigmatic. In this study, we independently overexpressed three Ok4CL isoforms from Ocimum kilimandscharicum (Ok4CL7, -11 and -15) in the plant species Nicotiana benthamiana, Solanum tuberosum and Arabidopsis thaliana for functional characterization. Interestingly, Ok4CL11 overexpression causes a rootless or reduced root growth phenotype, whereas overexpression of other two isoforms (Ok4CL7 and -15) resulted in normal adventitious root growth. Overexpression of Ok4CL11 in N. benthamiana leads to abundance of flavonoid-glycosides (i.e. kaempferol-3,7-O-bis-alpha-L-rhamnoside [K3,7R], quercetin-3-O-rutinoside [Q3R]), reduces auxin levels, and disrupts auxin transport and signaling, which cumulatively results in a rootless phenotype. In silico studies show that auxin transporters (PINs/LAXs) have higher binding affinity to K3,7R than to auxins, suggesting a potential disruption of auxin transport by the flavonoid-glycosides accumulated in Ok4CL11-OE lines. Our study reveals a unique indirect function of Ok4CL11 as a negative regulator of root growth, likely involving inhibition of auxin transport. As Ok4CL11 strongly affects root development, it is imperative to understand tissue-specific regulation of its gene expression and could be utilized for agricultural benefits.
AUTONOMIC DYSFUNCTION IN A WELDER FOLLOWING MANGANESE TOXICITY: A CASE REPORT
Authors: Singh Devesh Pratap , Choudhari Omkar Kalidasrao , Spalgais Sonam , Ojha Umesh Chandra
Published: February 2023

Background: Manganese induced autonomic dysfunction is one of the chronic debilitating entities known to be seen primarily in welders exposed to fumes at work place. Welders absorb these fumes via inhalational route. Manganese in these fumes gets deposited in the basal ganglia and cause neuronal loss predominantly in Globus Pallidus. Unfortunately, it is under diagnosed due to lack of awareness of the disease. Though path breaking researches have been carried out in the field of Parkinson’s disease (being main differential diagnosis of manganese toxicity), still very few advancements in the management of manganese toxicity is seen and only supportive therapy is helpful. Primarily, this autonomic dysfunction does not or poorly respond to levodopa which is a characteristic distinguishing factor from Parkinsonism.
Case: We are describing a case of a 50-years male presenting with complaints of slowness in the movement, gait instability with frequent falls. The patient has had persistent orthostatic hypotension. He had no significant family history and his work up showed no other cause of autonomic dysfunction. The patient had poor response to Levodopa. He had been exposed to welding fumes for 25 years. His MRI showed non-specific demyelination foci while SPECT scan was normal. The patient was diagnosed with occupational manganese toxicity based on history and Canadian consensus guidelines. The patient improved with oral fludrocortisone and bilateral lower limb elastic stockings.
Conclusion: Large scale promotion on the use of Personal Protective equipment (PPE) is required. Early intervention in these cases could save the patient from detrimental effect, decrease social economic burden and make better health related quality of life as only supportive care can be given once diagnosed.
ANALYSIS OF THYROID CANCER INCIDENCE AND MORTALITY TRENDS AMONG THE RESIDENTS OF THE SUMY REGION
Authors: Kurochkin Andrii , Moskalenko Yuliia
Published: February 2023

Introduction. Thyroid cancer ranks ninth in the structure of malignant neoplasms. Since the 1980s, most countries in the world have seen a rapid increase in the incidence rate and a relatively stable or even decreasing mortality rate.
The objective of our study was to analyze the thyroid cancer morbidity and mortality trends in the Sumy region during 2014–2021, to study the prevalence of histological variants and sex-age-specific characteristics, and to compare them with all-Ukrainian and global data.
Study results. According to the National Cancer Registry of Ukraine, 24,626 people were diagnosed with thyroid cancer between 2014 and 2021, including 4,556 men (18.5%) and 2,0070 women (81.5%). On average, 3078.25 ± 136.15 people were diagnosed per year. The incidence rate among women is 3.8 times higher than among men. The average incidence rate in Ukraine in 2014–2021 was 6.5 per 100,000 population, while in the Sumy region – 8.9 per 100,000 population.
The average mortality rates among residents of the Sumy region and Ukraine did not differ and amounted to 0.4 per 100,000 population. A distinctive feature was represented by the lower male and higher female mortality rates in the Sumy region compared to all-Ukrainian indicators (0.2 versus 0.3 per 100,000 population and 0.6 versus 0.4 per 100,000 population, respectively).
The study of histological types of thyroid malignancies demonstrated that papillary variant was most common (70.5 to 81.9%). The specific share of follicular cancer ranged from 12.8 to 19.2%. The medullary variant occured much less often – in 1.5 to 4.6% of cases, while undifferentiated and squamous cell cancer was extremely rare (0.2 to 3.3% of cases).
In Buryn district, Velyka Pysarivka district, Konotop district, Krasnopillia district, Krolevets district, Lebedyn district, Nedrygailiv district, Putyvl district, Sumy district, Trostyanets district and the city of Sumy, a significantly higher incidence rate was observed.
Women aged 50–64 and men aged 55–69 are most often affected in Ukraine. The highest mortality rate is reported for the age range of 70–84 years for both males and females.
Conclusions. During 2014–2021, the incidence and mortality rates among the population of Ukraine remained at a stable level and were lower compared to global indicators. Since 2017, the Sumy region has been presenting with a decrease in the incidence rate, which corresponds to European trends. In the Sumy region, papillary thyroid cancer remains the most common histological variant. In general, the shares of papillary, follicular, medullary, and anaplastic cancers are consistent with the European figures. In general, the age trends in Ukraine and other countries of the world are similar.
HEPATOPROTECTIVE EFFECT OF CRYOPRESERVED PLACENTA EXTRACT ON THE TETRACHLOROMETHANE LIVER INJURY
Authors: Koshurba Illia
Published: February 2023

Introduction. Toxic lesions of the hepatobiliary system are an important medical and social problem due to the steady increase in the frequency of chemical hepatosis, which develops as a result of accumulation of various xenobiotics in the body. Tetrachloromethane (CCl4) is one of the most studied hepatotoxins. Biochemical and pathomorphological changes in the liver lesions modeled by the administration of CCl4 are analogous to acute hepatitis of various etiologies in humans. As a potential hepatoprotective agent, cryopreserved placenta extract (CPE) attracted our attention.
The objective is to characterize the effect of cryopreserved placenta extract on the functional state of the liver of rats with tetrachloromethane-induced damage.
Materials and Methods. In vivo study was conducted on 28 male rats weighing 200–220 g. Acute CCl4-induced hepatitis was reproduced by injecting a 50.0% oil solution of CCl4 at a dose of 10 ml/kg body weight of the animal once, which caused acute fatty liver dystrophy. Animals were sacrificed 24 hours after the administration of CCl4. CPE was administered once per day for five days before CCl4 administration. The research material was blood and liver homogenates. The concentration of bilirubin in blood was determined by the spectrophotometrical method. The content of adenosine monophosphoric, adenosine diphosphoric, and adenosine triphosphoric acids was studied in the deproteinized homogenate by chromatographic method.

Results and discussion. It was established that the development of CCl4-induced hepatitis is accompanied by the formation of a cholestatic syndrome and a disorder of energy metabolism in liver tissues. This was indicated by an increase (p < 0.001) in the level of total bilirubin by 4.7 times and a decrease (p < 0.001) in the energy charge by 42.6% compared to the indicators of intact rats. Prophylactic five-day administration of CPE led to a decrease (p < 0.001) in the level of total bilirubin by 32.1% and a decrease (p < 0.001) in the levels of direct and indirect bilirubin by 10.6% and 65.1%, respectively, compared to the indicators of animals with experimental toxic hepatitis. This indicated the weakening of the cholestatic syndrome and, indirectly, the weakening of inflammatory infiltration against the background of cytolytic processes in the liver. CPE had an energy-stabilizing effect on hepatocytes of rats with simulated tetrachloromethane liver injury. This was indicated by an increase (p = 0.02) of the energy charge by 18.2% compared to the indicators in the control group.
Conclusions. The study showed anticholestatic and energy-stabilizing activity of the cryoextract of placenta used as a prophylactic measure in the model of tetrachloromethane-induced hepatitis.
PECULIARITIES OF THE COURSE, DIAGNOSIS, AND TREATMENT OF MULTIPLE SCLEROSIS
Authors: Potapov Oleksandr , Kmyta Oleksiy , Tsyndrenko Oleksandr , Makeyenko Iryna , Sumtsova Kateryna , Nikolaenko Yana
Published: February 2023

Introduction. Multiple sclerosis (MS) is a chronic progressive disease of the central nervous system, which is characterized by demyelination and degeneration of nerve fibers and has a polymorphic clinical picture and a tendency to an unfavourable course [1]. The disease usually affects young and working-age people, leading to early disability and poor quality of life, which makes it a socially significant problem of our time [2].
The main objective was to increase the efficiency of diagnosis and treatment of patients with multiple sclerosis based on a comprehensive analysis of clinical-neurological, psychodiagnostic, and neuroimaging features of the onset and course of the disease.
Materials and Methods: Clinical and neurological examination of patients using the Functional System Score (FSS) and Expanded Disability Status Scale (EDSS); cognitive functions examination using the Mini-Mental State Examination (MMSE), the clock-drawing test, the five-word test; brain magnetic resonance imaging; the 36-Item Short Form Health Survey (SF-36).
According to statistics, there are about 3 million patients with multiple sclerosis worldwide. In Ukraine, about 20,000 people have multiple sclerosis. Currently, a hypothesis has been made about multiple sclerosis as a multifactorial disease that is, to a great extent, attributable to genetic predisposition (i. e., features of the immune reaction) and the influence of external factors [1].
Multiple sclerosis mainly affects young and mature people – 12 to 55 years old. Although multiple sclerosis can sometimes make its debut in puberty, however, the frequency of the disease gradually increases with age up to the middle of the third decade of life, with a subsequent decrease up to the age of 50–60 [3]. Recently, a trend toward the rejuvenation of multiple sclerosis has been observed. About 3% of all patients with multiple sclerosis are children under 16. Multiple sclerosis debuting at a later age is not sufficiently studied and is rarely diagnosed, although in about 20% of patients, the first signs of this pathology appear after age 40 [4, 11].
Comparative pharmacoepidemiological characteristics of antibacterial drugs prescriptions used in patients with lower respiratory tract infection in a typical practice in Kursk and Chisinau
Authors: Povetkin Sergey V. , Gikavy Victor I. , Levashova Oksana V. , Kornilov Arsen A. , Bachinsky Nicolae G. , Podgursky Lilia A. , Tsurkan Lucia M. , Saraev Igor A.
Published: February 2023

Objective: to study the structure of medical prescriptions for antibacterial drugs used in patients with various types of infection of the bronchopulmonary system in the conditions of typical practice in Kursk (Russian Federation) and Chisinau (Republic of Moldova). Materials and methods. In order to assess the structure of prescribing various classes of antibacterial agents used to treat patients with infections of the respiratory system, a survey of doctors from medical organizations in Kursk and Chisinau was conducted in the period from October 2019. to January 2020 as a one-time descriptive study. As model diseases are taken: acute bronchitis with purulent sputum, exacerbation of chronic obstructive pulmonary disease with purulent sputum, non-severe community-acquired pneumonia. Results. The leaders in prescription for acute bronchitis with purulent sputum were cephalosporins: in Kursk, their share was 24% (cefixime was most often prescribed), and in Chisinau, 26.8% (leaders were cefixime and ceftriaxone). In patients with exacerbation of chronic obstructive pulmonary disease and purulent sputum, doctors from both cohorts also more often recommended cephalosporins: 29.4% and 36.1% for Kursk and Chisinau, respectively; among them, cefixime, ceftriaxone and cefotaxime were leaders in Kursk, while ceftriaxone, cefotaxime and cefuroxime axetil were the priorities in Chisinau. For non-severe community-acquired pneumonia, doctors in Kursk preferred macrolides (more often - azithromycin and clarithromycin), inhibitor-protected penicillins (more often - amoxicillin/clavulanate) and cephalosporins (mainly of the 3rd generation), in Chisinau, cephalosporins (mainly of the 3rd generation) and penicillins (including inhibitor-protected) were more often prescribed, the proportion of macrolides was significantly less. Conclusion. Doctors from Chisinau and Kursk implement pharmacotherapy for this group of patients in accordance with modern clinical guidelines; at the same time, cases of irrational use of certain medicines are recorded.
Behavioral abnormalities in a genetic model of Duchenne myodystrophy in mice
Authors: Soldatov Vladislav O. , Karagodina Anastasia Yu. , Patrakhanov Evgeny A. , Pokrovsky Vladimir M. , Puchenkova Olesya A. , Belashova Anastasia V. , Egorova Tatyana V. , Polikarpova Anna V. , Deikin Aleksey V. , Pokrovsky Mikhail V.
Published: February 2023

Mutations in the Dmd gene encoding the membrane protein dystrophin are associated with the development of severe X-linked muscle diseases Duchenne and Becker myodystrophy. At the same time, along with the classic symptoms of striated muscles, dystrophin mutations can lead to a decrease in cognitive functions and behavioral abnormalities. Objective: conducting a pilot analysis of behavioral and cognitive characteristics in mice with a genetic defect that reproduces the phenotype of Duchenne myodystrophy. Materials and methods. To assess the features of motor functions and behavior, DmdDel8-34(n=13) and control animals of the wild type (n=12) were subjected to research in the tests "Load retention", "Rotarod", "Elevated plus maze" and "Object recognition". Results. It was found that mice carrying the DmdDel8-34 mutation are characterized by a decrease in motor functions, show signs of anxiety, and also show low exploratory activity. The detected features of the cognitive and emotional status are consistent with clinical observations indicating an increased risk of developing autism spectrum disorders and obsessive-compulsive disorder in patients with Dmd gene mutations. Thus, it was proved that from the 8th week of life, mice of the DmdDel8-34 line show a decrease in performance in the Rotarod and Load Retention tests. Behavioral testing in the Elevated Plus Maze test revealed a decrease in time reaching a statistically significant difference compared to the wild-type control at week 12, and when assessing cognitive functions in the Object Recognition test, it was shown that DmdDel8-34mice show an increase in the discrimination index value, which is a sign of increased efficiency of hippocampal memory. Conclusion. The study made it possible to identify some behavioral anomalies in genetically modified mice carrying a large deletion of exons 8-34 of the Dmd gene encoding dystrophin.
Differential clinical and morphological approach to the study of placental calcification
Authors: Kaplin Anton N. , Pavlova Tatyana V. , Fetisova Alevtina I. , Kaplina Karina R. , Kelyamova Karina E.
Published: February 2023

Objective: to detect possible causes of calcification of the placenta, identify patterns between excessive deposition of fibrinoid, calcium salts and various disorders in the mother-placenta-fetus system. Materials and methods. 6,089 afterbirths and placental tissue sections were examined, of which 193 specimens complying with the purpose of the study were further studied and divided into three groups (group of biological norm; afterbirths in which there is fibrinoid deposition without accompanying calcification; afterbirths with pronounced deposits of calcium salts). Each section of placental tissue was studied macro- and microscopically according to the method of A.P. Milovanov and A.I. Brusilovsky to reveal structural and functional changes. Statistical processing of the results was performed using methods of descriptive statistics, nonparametric methods: compilation of contingency tables, calculation of Pearson's χ2 test with Yates correction. Results. It was found that all the afterbirths studied had similar macroscopic characteristics. Microscopic examination revealed that calcification contributes to a more pronounced separation of the lobules of the maternal part of the placenta. Various inflammatory, alterative processes, as well as hemodynamic disorders in the placental tissue contribute to the deposition of calcium salts. Conclusion. The involutive processes observed in normal aging of the placenta become most pronounced in various pathological processes in the mother-fetus-placenta system. The study revealed a statistically significant relationship between the number of labor and the appearance of calcifications in the placental tissue. Large focal deposits of calcium salts were more often observed in women who gave birth not for the first time.
Changes in cytokine levels in the blood of eczema patients with complex treatment with upadacitinib
Authors: Novikova Lyubov A. , Dontsova Elena V. , Chernov Alexey V. , Saurina Olga S. , Dontsov Vladimir G. , Borzunova Larisa N. , Pogodaeva Tamara I.
Published: February 2023

Objective: to study changes in immunological parameters in patients with true eczema during complex therapy with the use of upadacitinib. Materials and methods. The work was performed with the participation of 131 patients aged 18 to 70 years (average age 58.7±3.6 years) with a diagnosis of true eczema, who were on inpatient treatment. The patients were divided into 4 groups: the first group received basic drug therapy (BMT), the second - phototherapy (FT) and BMT (BMT+FT), the third - upadacitinib (UPA) and BMT (BMT+ UPA), the fourth - BMT+FT+UPA. The content of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients was determined by enzyme immunoassay before the start of treatment and 2 and 4 months after its start. Results. Before the start of treatment, the values of IL-1ß, IL-2, IL-6, IL-10, INF-γ, TNF-α in the blood serum of patients in comparison with healthy individuals were significantly increased (3.7-4.2 times) against the background of a decrease in the level of IL-10 (2 times). In patients of the first group, the cytokine level did not change significantly after 2 and 4 months from the start of treatment in comparison with the indicators before the start of treatment. In the second group, at all follow-up periods, the content of IL-10 significantly increased with a decrease in the levels of IL-1ß, IL-2 and IL-6. When using UPA in the third group, the content of IL-10 increased against the background of a marked decrease in all other cytokines studied. The greatest changes were noted in the fourth group during the complex treatment of UPA with FT and BMT: a significantly significant decrease in the levels of IL-1, IL-2, IL-6, INF-γ, TNF-α (by 53-67%, p<0.001) against the background of an increase in the content of IL-10 (by 69%, p<0.001). The preservation of the orientation and severity of the identified shifts after 4 months indicates their stability. Conclusion. In patients with true eczema, the use of upadacitinib as part of complex treatment in combination with basic drug therapy and phototherapy causes a pronounced and prolonged correction of the cytokine profile in the blood.
Characteristics of jaw force relations in rehabilitation of patients with total tooth loss and removable dentures: a clinical and pathophysiological study
Authors: Kerimkhanov Kamil’ A. , Bobyntsev Igor I. , Iordanishvili Andrey K.
Published: February 2023

At the present time the complete loss of teeth is frequent, especially in older age groups, and their rehabilitation with the use of full removable acrylic dentures is not always effective. Objective: to estimate the peculiarities of patients adaptation to the full removable dentures taking into account the jaw strength characteristics and application of adhesive agents to improve denture fixation. Materials and methods. 34 elderly women suffering from the total loss of teeth were under observation. Group 1 consisted of 15 patients, who after fabrication of full removable dentures, during the whole adaptation period did not use any adhesive means for improvement of fixation of removable dentures and group 2 used ASEPTA parodontal cream for fixation of dentures. Indexes of gnathodinamometry and indexes of test with nucleus according to I.S. Rubinov were evaluated in all patients after fitting and application of prosthesis. Results. It has been established, that good jaw strength characteristics (81-105 N), as well as good fixation and stabilization of new dental restorations are determined during rehabilitation of patients with full tooth loss using removable dentures. The study has shown that to optimize the force characteristics of the jaws while using the full removable acrylic dentures and to increase their stability it is possible to use adhesive means for fixing dentures, thus reducing the number of visits for denture correction to 1.25±0.41 and improving gnathodinamometry parameters by 7.21-29.1%. Conclusion. Dental rehabilitation of complete tooth loss with full removable acrylic dentures is quite effective, especially when using removable denture fixation means. The use of the latter requires increased oncological vigilance due to the presence of chronic traumatic lesions of the oral mucosa, proceeding without painful symptoms and being facultative precancer.
Determination of the optimal conditions for the extraction of anthraglycosides of alder buckthorn bark, development and validation of a method for their quantitative determination by high performance liquid chromatography
Authors: Romanyuk Anna A. , Moiseev Dmitry V.
Published: February 2023

Objective: optimization of extraction conditions for anthraglycosides of alder buckthorn bark, development and validation of a method for their quantitative determination using high performance liquid chromatography. Materials and methods. The object of the study was alder buckthorn bark from different manufacturers. The work was performed on an Agilent 1100 liquid chromatograph complete with a G1311A four-solvent supply and degassing system, a G1315B diode array detector, a G1316A column thermostat, and a G1313A automatic sample injection device. Chromatographic analysis was carried out on a Zorbax SB-C18 reverse-phase column (4.6×250 mm, 5 μm) in a gradient elution mode of the mobile phase consisting of acetonitrile and highly purified water, adjusted to pH 2 with phosphoric acid. Results. As a result of the study, the optimal conditions for the chromatographic separation of anthraglycosides of alder buckthorn bark were determined. The optimal conditions for their extraction have been established: the grinding of plant raw materials is 250 µm, the extractant is ethyl alcohol 40%, the extraction temperature is 80℃, the extraction time is 90 minutes, the ratio of raw materials and extractant is 1:50. It has been proved that the developed method for the quantitative determination of anthraglycos
OS PILARES DA JUSTIÇA DE TRANSIÇÃO NO BRASIL: UMA ABORDAGEM DOS ASPECTOS HISTÓRICOS DE IMPUNIDADE, DE VIOLÊNCIA E DE EXPLORAÇÃO
Authors: Macedo de Souza Cláudio , PEREIRA RAFAEL , Ramos Bezerra Vinicius
Published: February 2023

O artigo objetiva trazer ao debate a influência dos principais aspectos históricos de violência e de exploração sobre o modelo de Justiça de Transição adotado no Brasil, o qual isentou da responsabilidade penal os agentes violadores de direitos humanos. Durante as décadas de 1960 e 1970, no contexto da Guerra Fria, ocorreram diversos golpes de Estado em países da América Latina, dentre os quais, está o Brasil. Com o fim da ditadura civil-militar, o país priorizou a efetivação do direito à reparação e pouco ou nenhum progresso no que tange à responsabilização dos agentes do regime militar de 1964. Atento a essa situação, indagou-se: “Quais razões guiaram a decisão do Brasil na adoção de uma Justiça de Transição afastada da responsabilidade penal, mesmo diante das graves violações aos Direitos Humanos?” A proteção internacional da pessoa está nos mais diversos documentos assinados pelo Brasil. Entretanto, a Lei de Anistia é incompatível com a proteção internacional da pessoa pois, ao se afastar da responsabilidade penal dos agentes, cria desrespeito e desvalorização dos direitos humanos para as vítimas e para a sociedade. A metodologia proposta neste artigo procura correlacionar fatos históricos com a ausência de responsabilidade penal, como forma de alertar sobre a necessidade de construir uma cultura de respeito e fortalecimento aos direitos humanos pelas forças de segurança pública do Estado Democrático de Direito brasileiro.
GUERRA FISCAL INTERNACIONAL: O PARADOXO ENTRE ARRECADAÇÃO E ATENDIMENTO AOS DIREITOS FUNDAMENTAIS DO CIDADÃO
Authors: Basilio Vailatti Diogo , Ferreira Junior Rubens
Published: February 2023

O trabalho se funda no binômio entre arrecadação e adimplemento/custos dos direitos sociais. Aplica-se os efeitos da guerra fiscal e as consequências frente os contribuintes pessoas físicas e jurídicas – em especial os de médio e pequeno porte – e a pratica desleal veiculada por paraísos fiscais. Este fenômeno foi possibilitado pela globalização da economia e o surgimento de empresas transnacionais o que acelerou a crise arrecadatória ao revés da isonomia e da lealdade concorrencial. A pesquisa utilizará o método de pesquisa hipotético-dedutivo com análise bibliográfica.
Pareceristas de 2022
Authors: Sánchez-Tarragó Nancy
Published: February 2023

Nosso agradecimento aos pareceristas que colaboraram com a preparação do volume 6 de 2022 da Revista Informação na Sociedade Contemporânea, contribuindo com a qualidade dos artigos que publicamos.
Reflexões sobre o termo e conceito ‘Informação Arqueológica’
Authors: Santana Sérgio Rodrigues de , Martins Eliane Epifane , Menezes Lília Mara de , Melo Maytê Luanna Dias de , Girard Carla Daniella Teixeira
Published: February 2023

O artigo refletiu sobre algumas bases epistêmicas do termo/conceito ‘informação arqueológica’, e a justificativa do estudo versou na ampliação e atualizar dos estudos da Terminologia Arqueológica Brasileira na perspectiva interdisciplinar da Ciência da Informação que busca manter no escopo de suas reflexões dos grupos e comunidades científicas. Se baseou no método compreensivo-descritivo-interpretativo, apoiado nos estudos Terminológicos e da Representação da Informação, para obter os resultados que demostram que a Informação Arqueológica é um conjunto de vestígios, evidências, indícios e pistas localizados e tratados. Assim, é um conjunto de informação e conhecimento sobre os aspectos culturais, sociais identitários, e materiais (tecnologias ornamentais e tecnológicas técnicas), de uma determinada sociedade e/ou grupo pertencente a um passado ágrafo. A informação arqueológica tem o potencial de visualização do contexto de antecipações culturais, sociais, identitários, ambientais e tecnológicos das sociedades atuais e seus impactos para as sociedades do futuro, tendo em vista a sua essencialidade memorialístico-histórica que constitui a cultura material (conhecimento). Sua aplicação versa sobre a representação eficiente e eficaz (temática - indexação/descritiva - catalogação) de seus objetos (materiais) de estudos; facilita a linguagem escrita dos(das) arqueólogos(as); subsidia as oralidades intergrupal e individual dos(das) profissionais arqueólogos(as); minimiza o teor ambíguo e ambivalente da SI; facilita a disseminação da Informação Arqueológica, para além das confrarias acadêmicas; facilita a promoção da interdisciplinaridade com outras áreas, especialmente, para áreas como a história, museologia, arquivologia, biblioteconomia, antropologia, paleontologia e outras e gerencia a informação/conhecimento arqueológico quanto à antecipação social, cultural e ambiental atual.
LncRNA-mediated Modulation of Endothelial Cells: Novel Progress
in the Pathogenesis of Coronary Atherosclerotic Disease
Authors: Ouyang Shao , Zhou Zhi-Xiang , Liu Hui-Ting , Ren Zhong , Liu Huan , Deng Nian-Hua , Tian Kai-Jiang , Zhou Kun , Xie Hai-lin , Jiang Zhi-Sheng
Published: February 2023

Coronary atherosclerotic disease (CAD) is a common cardiovascular disease
and an important cause of death. Moreover, endothelial cells (ECs) injury is an early
pathophysiological feature of CAD, and long noncoding RNAs (lncRNAs) can modulate
gene expression. Recent studies have shown that lncRNAs are involved in the pathogenesis
of CAD, especially by regulating ECs. In this review, we summarize the novel
progress of lncRNA-modulated ECs in the pathogenesis of CAD, including ECs proliferation,
migration, adhesion, angiogenesis, inflammation, apoptosis, autophagy, and pyroptosis.
Thus, as lncRNAs regulate ECs in CAD, lncRNAs will provide ideal and novel targets
for the diagnosis and drug therapy of CAD.
Leishmaniasis: Omics Approaches to Understand its Biology from Molecule
to Cell Level
Authors: Kumari Indu , Lakhanpal Dinesh , Swargam Sandeep , Nath Jha Anupam
Published: February 2023

Leishmaniasis is the second deadliest vector-borne, neglected tropical zoonotic disease and
is found in a variety of clinical forms based on genetic background. Its endemic type is present in tropical,
sub-tropical and Mediterranean areas around the world which accounts for a lot of deaths every
year. Currently, a variety of techniques are available for detection of leishmaniasis each technique having
it's own pros and cons. The advancing next-generation sequencing (NGS) techniques are employed
to find out novel diagnostic markers based on single nucleotide variants. A total of 274 NGS studies
are available in European Nucleotide Archive (ENA) portal (https://www.ebi.ac.uk/ena/browser/home)
that focused on wild-type and mutated Leishmania, differential gene expression, miRNA expression,
and detection of aneuploidy mosaicism by omics approaches. These studies have provided insights into
the population structure, virulence, and extensive structural variation, including known and suspected
drug resistance loci, mosaic aneuploidy and hybrid formation under stressed conditions and inside the
midgut of the sandfly. The complex interactions occurring within the parasite-host-vector triangle can
be better understood by omics approaches. Further, advanced CRISPR technology allows researchers
to delete and modify each gene individually to know the importance of genes in the virulence and survival
of the disease-causing protozoa. In vitro generation of Leishmania hybrids are helping to understand
the mechanism of disease progression in its different stages of infection. This review will give a
comprehensive picture of the available omics data of various Leishmania spp. which helped to reveal
the effect of climate change on the spread of its vector, the pathogen survival strategies, emerging antimicrobial
resistance and its clinical importance.
Exosomal miRNAs as Next-generation Therapy Vehicles in Breast Cancer
Authors: Thakur Priyanka , Dahiya Harshita , Kaushal Ankur , Gupta Vijai Kumar , Saini Adesh K. , Saini Reena V.
Published: February 2023

The second most pervasive cancer affecting the survival of women across the world is
breast cancer. One of the biggest challenges in breast cancer treatment is the chemoresistance of cancer
cells to various medications after some time. Therefore, highly specific blood-based biomarkers
are required for early breast cancer diagnosis to overcome chemoresistance and improve patient survival.
These days, exosomal miRNAs have attracted much attention as early diagnostic blood-based
biomarkers because of their high stability, secretion from malignant tumor cells, and excellent specificity
for different breast cancer subtypes. In addition, exosomal miRNAs regulate cell proliferation,
invasion, metastasis, and apoptosis by binding to the 3′UTR of their target genes and limiting their
production. This review focuses on the functions of exosomal miRNAs in tumorigenesis via targeting
multiple signaling pathways as well as chemosensitivity and resistance mechanisms. In addition, the
growing pieces of evidence discussed in this review suggest that circulating exosomal miRNAs could
be utilized as potential next-generation therapeutic target vehicles in the treatment of breast cancer.
CRISPR-Cas9: A Potent Gene-editing Tool for the Treatment of Cancer
Authors: Mishra Gauri , Srivastava Kamakshi , Rais Juhi , Dixit Manish , Kumari Singh Vandana , Chandra Mishra Lokesh
Published: February 2023

The prokaryotic adaptive immune system has clustered regularly interspaced
short palindromic repeat. CRISPR-associated protein (CRISPR-Cas) genome
editing systems have been harnessed. A robust programmed technique for efficient
and accurate genome editing and gene targeting has been developed. Engineered cell
therapy, in vivo gene therapy, animal modeling, and cancer diagnosis and treatment
are all possible applications of this ground-breaking approach. Multiple genetic and
epigenetic changes in cancer cells induce malignant cell growth and provide chemoresistance.
The capacity to repair or ablate such mutations has enormous potential in
the fight against cancer. The CRISPR-Cas9 genome editing method has recently become
popular in cancer treatment research due to its excellent efficiency and accuracy.
The preceding study has shown therapeutic potential in expanding our anticancer
treatments by using CRISPR-Cas9 to directly target cancer cell genomic DNA in cellular
and animal cancer models. In addition, CRISPR-Cas9 can combat oncogenic infections
and test anticancer medicines. It may design immune cells and oncolytic viruses
for cancer immunotherapeutic applications. In this review, these preclinical CRISPRCas9-
based cancer therapeutic techniques are summarised, along with the hurdles
and advancements in converting therapeutic CRISPR-Cas9 into clinical use. It will
increase their applicability in cancer research.
The Biological and Pharmacological Potentials of Indole-based Heterocycles
Authors: Sharma Shivangi , Singh Shivendra
Published: February 2023

An important bioactive heterocycle having several uses in medicinal chemistry, synthetic
organic chemistry, material chemistry, and natural product is indole along with its analogues. Many
bioactive indole-based heterocycles have important antibacterial, anti-inflammatory, analgesic, antiviral,
antimalarial, chemotherapeutic, antifungal, and anti-TB effects, as well as antioxidant capabilities.
Several well-known medications, including tadalafil, rizatriptan, sumatriptan, and fluvastatin are indole-
based potential bioactive compounds. Based on the existing and latest evidence, researchers have
focused on developing indole-based compounds with novel biological and pharmacological properties
for decades. Owing to useful bioactivities, we have described many bioactive indoles and their synthetic
methods in this review article.
Electrolyte Imbalance and Neurologic Injury
Authors: Poe Jordan , Sriram Sai , Mehkri Yusuf , Lucke-Wold Brandon
Published: February 2023

Neurologic injury continues to be a debilitating worldwide disease with high morbidity and
mortality. The systemic sequelae of a neural insult often lead to prolonged hospital stays and challenging
nutritional demands that contribute to poorer prognoses. Clinical management of a given condition
should prioritize preserving the homeostatic parameters disrupted by inflammatory response cascades
following the primary insult. This focused review examines the reciprocal relationship between electrolyte
disturbance and neurologic injury. A prolonged electrolyte imbalance can significantly impact
morbidity and mortality in neurologic injuries. A detailed overview of the major electrolytes and their
physiologic, iatrogenic, and therapeutic implications are included. The pathophysiology of how
dysnatremias, dyskalemias, dyscalcemias, and dysmagnesemias occur and the symptoms they can induce
are described. The manifestations in relation to traumatic brain injury, status epilepticus, and acute ischemic
stroke are addressed. Each type of injury and the strength of its association with a disruption in
either sodium, potassium, calcium, or magnesium is examined. The value of supplementation and replacement
is highlighted with an emphasis on the importance of early recognition in this patient population.
This review also looks at the current challenges associated with correcting imbalances in the
setting of different injuries, including the relevant indications and precautions for some of the available
therapeutic interventions. Based on the findings of this review, there may be a need for more distinct
clinical guidelines on managing different electrolyte imbalances depending on the specified neurologic
injury. Additional research and statistical data on individual associations between insult and
imbalance are needed to support this potential future call for context-based protocols.
Programmed Cell Death Protein 1 (PD-1) in Relation to PANoptosis: Immune
Pharmacological Targets for Management of Breast Adenocarcinoma
Authors: Maitra Subarnarekha , Bhattacharya Debarati , Paul Souvik , Chowdhury Payel Ghosh , Mandal Dipanjan , Haldar Pallab Kanti , Balaraman Ashok Kumar , Bala Asis
Published: February 2023

Programmed cell death protein 1 or Programmed death-1 (PD-1) and Programmed Cell
Death Ligand 1 (PD-L1) research have tremendously been taken into great consideration in the field
of cancer immune pharmacology. Cancer immunotherapy has been convoyed by a capable outcome
over the past few years. PD-1 and PD-L1 play a pivotal role in attenuating immune involvement,
modulating the activity of T-cells, and promoting different types of programmed cell death. Participation
of antigen-specific T cells and regulatory T cells and their acute mutations during cancer
cell invasion and migration may lead to challenges for three programmed cell death methods,
namely, pyroptosis, apoptosis, and necroptosis called “PANoptosis”. This review aimed to explore
the correlation between the PD-1/PD-L1 pathway in “PANoptosis” using available recently published
literature with several schematic representations. Hopefully, the review will facilitate the
biomedical scientist targeting cancer immune pharmacological aspect for the management of Breast
Adenocarcinoma shortly.
Effect of Yoga Nidra (Psychic Sleep) in patients with Alcoholic Hypertensives - A Randomized Controlled Trial
Authors: Shalmali  , Das Prasul , Shetty Prashanth
Published: February 2023

Background: Primary Hypertension in alcoholic individuals is one of the major health issues of the society. Yoga is found to have a wonderful tool to treat primary hypertension in alcoholic individuals. Yoga Nidra, is a cost effective tool to manage these symptoms. Objectives: The objectives of the study are to assess whether Yoga Nidra is having effect on blood pressure, heart rate variability & respiratory rate in primary hypertensive alcohol dependent individuals. Materials and Methods: A total of sixty primary hypertensive alcoholic dependent individuals have been recruited after they meet the inclusion and exclusion criteria and the screening of the subjects by using Alcohol Use Disorders Identification Test (AUDIT) questionnaire and into two Groups, Subjects in the group one practiced Yoga Nidra for a period of 10 days and group two carried on its routine activities. Both the groups were assessed for blood pressure, heart rate variability & respiratory rate at day one and day ten. Results: In the present study comparison between the group there was a significant results seen in the HR, RR, SBP with P value < 0.0001, LF/HF ratio with P value < 0.0500, DBP with P value< 0.0257 respectively. Conclusion: Ten days of Yoga Nidra practice has shown to bring a positive influence in primary hypertensive alcoholic dependent individuals in improving HR, RR, Mean RR, RMSSD, NN50, PNN50, VLF, LF, HF, LF/HF ratio, SBP & DBP.