bluuebunny/crossref_metadata_2025 huggingface dataset:
New Quantum-Dot-Based Fluorescent Immunosensor for Cancer Biomarker Detection
Authors: Sousa Mariana P. , Piloto Ana Margarida L. , Pereira Ana Cláudia , Schmitt Fernando C. , Fernandes Ruben , Moreira Felismina T. C.
Published: December 2022

Cancer antigen 15-3 (CA 15-3) is a biomarker for breast cancer used to monitor response to treatments and disease recurrence. The present work demonstrates the preparation and application of a fluorescent biosensor for ultrasensitive detection of the cancer antigen CA 15-3 protein tumor marker using mercaptopropionic-acid-functionalized cadmium telluride (CdTe@MPA) quantum dots (QDs) conjugated with CA 15-3 antibodies. First, the QDs were synthesized by the hydrothermal route, resulting in spherical nanoparticles up to 3.50 nm in diameter. Subsequently, the QD conjugates were characterized by Fourier transform infrared spectroscopy (FTIR), UV absorption, and fluorescence. The interaction between the conjugates and the protein was studied by fluorescence spectroscopy in buffer and in 10-fold diluted commercial human serum. Calibration in spiked serum samples gave a detection limit of 0.027 U/mL, 1000-fold lower than the clinical limit for CA 15-3 (25 U/mL to 30 U/mL), indicating that this is an ultrasensitive technique. In addition, a rapid response was obtained within 10 min. The biosensor was selective in the presence of the interfering serum proteins BSA, CEA, and CA-125, with a maximum interference of 2% for BSA. The percent recovery was close to 100% with maximum relative standard deviation (RSD%) values of 1.56. Overall, the developed CA 15-3 biosensor provides a simple and sensitive method for ultrasensitive monitoring of breast cancer, as well as the ability to detect other molecules of interest in human serum matrices.
Perceptions of Mothers about Support and Self-Efficacy in Breastfeeding: A Qualitative Study
Authors: Gálvez-Adalia Esther , Bartolomé-Gutiérrez Raquel , Berlanga-Macías Carlos , Rodríguez-Martín Beatriz , Marcilla-Toribio Irene , Martínez-Andrés María
Published: December 2022

Breastfeeding is a complex process influenced by different personal and social factors which will determine both the initiation and the resilience for its maintenance. The aim is to identify the beliefs and expectations of mothers concerning breastfeeding to determine the perception of their self-efficacy and the influence on the management of their babies’ feeding. A qualitative study through semi-structured interviews was carried out. The sample size was defined by the saturation criteria. Twenty-two women participated, eleven were from an urban environment and eleven were from a rural environment. Mothers’ knowledge of breastfeeding, their expectations of that process, their experience, and their strategies for overcoming problems associated with initiating, establishing, and continuing breastfeeding were influenced by the role of nurses and midwives in supporting their perception of self-efficacy. Likewise, maternity policies are important for the continuance of exclusive breastfeeding. This study shows the complexity of the initiation and establishment of breastfeeding and the existence of several social factors surrounding these moments. Furthermore, it demonstrates the importance and reference of nurses and midwives and the role of State maternity policies.
Comparison of Glycosylated Haemoglobin, Blood Pressure, and Anthropometric Measurements Depending on Gender and Bodyweight State in Adolescents
Authors: Carlos-Vivas Jorge , Castillo-Paredes Antonio , Gómez-Galán Rafael , Muñoz-Bermejo Laura , Mendoza-Muñoz María , Adsuar Jose Carmelo , Pastor-Cisneros Raquel , Calle-Guisado Violeta
Published: December 2022

Background/Objective: The greatest anthropometric and physiological changes occur during adolescence. Assessment of growth patterns is necessary to prevent future health risks. Aims: To describe the values of glycosylated haemoglobin (HbA1c), systolic (SBP) and diastolic (DBP) blood pressure, triceps skinfold, and abdominal circumference according to gender and age (between 12 and 17 years), as well as explore the differences between body weight conditions. Methods: A descriptive cross-sectional study was carried out, including 4130 adolescents between 12 and 17 years old. SBP and DBP, HbA1c, triceps skinfold, and abdominal circumference were evaluated. Results: Significant differences were observed between males and females for HbA1c (p < 0.001), SBP (p < 0.001), triceps curl (p < 0.001), and abdominal circumference (p < 0.001), independently of the age group. Regardless of gender and age groups, significant differences were observed between overweight/obese and normal-weight adolescents in SBP (p < 0.001), DBP (p < 0.001 to 0.009), triceps skinfold (p < 0.001), and abdominal perimeter (p < 0.001). Conclusions: Our findings revealed higher SBP, DBP, triceps skinfold, and abdominal circumference in overweight/obese adolescents compared to normal-weight adolescents in both genders.
Agile Development Methodologies and Natural Language Processing: A Mapping Review
Authors: Quintana Manuel A. , Palacio Ramón R. , Soto Gilberto Borrego , González-López Samuel
Published: December 2022

Agile software development is one of the most important development paradigms these days. However, there are still some challenges to consider to reduce problems during the documentation process. Some assistive methods have been created to support developers in their documentation activities. In this regard, Natural Language Processing (NLP) can be used to create various related tools (such as assistants) to help with the documentation process. This paper presents the current state-of-the-art NLP techniques used in the agile development documentation process. A mapping review was done to complete the objective, the search strategy is used to obtain relevant studies from ScienceDirect, IEEE Xplore, ACM Digital Library, SpringerLink, and Willey. The search results after inclusion and exclusion criteria application left 47 relevant papers identified. These papers were analyzed to obtain the most used NLP techniques and NLP toolkits. The toolkits were also classified by the kind of techniques that are available in each of them. In addition, the behavior of the research area over time was analyzed using the relevant paper found by year. We found that performance measuring methods are not standardized, and, in consequence, the works are not easily comparable. In general, the number of related works and its distribution per year shows a growing trend of the works related to this topic in recent years; this indicates that the adoption of NLP techniques to improve agile methodologies is increasing.
Privacy Protection Scheme for the Internet of Vehicles Based on Private Set Intersection
Authors: Zhou Quan , Zeng Zhikang , Wang Kemeng , Chen Menglong
Published: December 2022

Performing location-based services in a secure and efficient manner that remains a huge challenge for the Internet of Vehicles with numerous privacy and security risks. However, most of the existing privacy protection schemes are based on centralized location servers, which makes them all have a common drawback of a single point of failure and leaking user privacy. The employment of anonymity and cryptography is a well-known solution to the above problem, but its expensive resource consumption and complex cryptographic operations are difficult problems to solve. Based on this, designing a distributed and privacy-secure privacy protection scheme for the Internet of Vehicles is an urgent issue for the smart city. In this paper, we propose a privacy protection scheme for the Internet of Vehicles based on privacy set intersection. Specially, using privacy set intersection and blockchain techniques, we propose two protocols, that is, a dual authentication protocol and a service recommendation protocol. The double authentication protocol not only ensures that both communicating parties are trusted users, but also ensures the reliability of their session keys; while the service recommendation protocol based on pseudorandom function and one-way hash function can well protect the location privacy of users from being leaked. Finally, we theoretically analyze the security that this scheme has, i.e., privacy security, non-repudiation, and anti-man-in-the-middle attack.
Physical Visitor Access Control and Authentication Using Blockchain, Smart Contracts and Internet of Things
Authors: Stock Frederick , Kurt Peker Yesem , Perez Alfredo J. , Hearst Jarel
Published: December 2022

In this work we explore the use of blockchain with Internet of Things (IoT) devices to provide visitor authentication and access control in a physical environment. We propose the use of a “bracelet” based on a low-cost NodeMCU IoT platform that broadcasts visitor location information and cannot be removed without alerting a management system. We present the design, implementation, and testing of our system. Our results show the feasibility of implementing a physical access control system based on blockchain technology, and performance improvements over a similar system proposed in the literature.
Association of Sun Safety Behaviors and Barriers with Sunburn History in College Students in a Region with High UV Exposure
Authors: Miller Dylan T. , Baccam Zoe , Harris Robin B.
Published: December 2022

Over five million cases of skin cancer are diagnosed each year in the United States with melanoma the third most common cancer in young adults. While publications have shown that sunburns increase the risk of developing melanoma throughout the lifetime including in adolescence and adulthood showing the importance of altering sun exposing behaviors throughout the lifetime, use of sun protection in college students remails low. In Fall 2019, an online survey of undergraduate students living on campus at a large southwestern university was conducted to determine the frequency of recent sunburns as well as sun protective behaviors and perceived knowledge of and barriers to sun protection. Associations between knowledge, behaviors, and barriers with self-reported sunburn were evaluated using logistic regression. Over 46% of 458 students reported at least one sunburn in the past three months and 21% reported having multiple sunburns in that period. Furthermore, 53% reported that they intentionally tanned their skin outdoors occasionally or more frequently, while 6.4% reported using an indoor tanning bed occasionally or more. Adjusted for skin sensitivity, recent sunburn history was associated with higher tanning activity scores and with high agreement that tanning was attractive (p < 0.01). This information can inform a more targeted series of intervention programming on the university campus.
Field Theory Approaches to Relativistic Hydrodynamics
Authors: Mirón Granese Nahuel , Kandus Alejandra , Calzetta Esteban
Published: December 2022

Just as non-relativistic fluids, oftentimes we find relativistic fluids in situations where random fluctuations cannot be ignored, with thermal and turbulent fluctuations being the most relevant examples. Because of the theory’s inherent nonlinearity, fluctuations induce deep and complex changes in the dynamics of the system. The Martin–Siggia–Rose technique is a powerful tool that allows us to translate the original hydrodynamic problem into a quantum field theory one, thus taking advantage of the progress in the treatment of quantum fields out of equilibrium. To demonstrate this technique, we shall consider the thermal fluctuations of the spin two modes of a relativistic fluid, in a theory where hydrodynamics is derived by taking moments of the Boltzmann equation under the relaxation time approximation.
Feasibility & Acceptability of Patient and Family Directed Active Music Making during Pediatric Bone Marrow Transplant Process
Authors: Heiderscheit Annie
Published: December 2022

(1) Background: Bone marrow transplant (BMT) is an aggressive and complex medical treatment for children with certain types of cancer and other diseases. The transplant process entails replacing the patient’s diseased bone marrow with the healthy marrow of a donor. During the course of treatment, patients are isolated in their room to reduce the risk of infection. Patient’s experience a variety of symptoms and side effects during the process including nausea, vomiting, diarrhea, mouth sores, fatigue, pain, discomfort, extreme muscle weakness, and emotional distress. Children often need a parent or caregiver present with them at all times throughout treatment. This process can cause significant stress and anxiety for the patient and their family. (2) Methods: This study explored the feasibility and acceptability of a patient and family directed active music making protocol during the BMT process. Ten patients, their parents, and family members participated in the study during the course of the BMT. (3) Results: Participants reported engaging in active music making 3–4 times per week and completed 121 journal forms reporting their music making experiences. They indicated using active music making to manage pain, discomfort, stress, anxiety, and boredom, foster relaxation and sleep, for enjoyment, and as a way to connect. (4) Conclusions: Patients, parents and family members reported feeling a sense of empowerment when engaged in making music to support their child or loved one.
Molecular Characterization and Dietary Regulation of Glutaminase 1 (gls1) in Triploid Crucian Carp (Carassius auratus)
Authors: Xiao Yangbo , Huang Rong , Cao Shenping , Zhao Dafang , Mao Zhuangwen , Xiao Chuchu , Xu Zhehua , Zhou Xiaomei , Zhang Xinran , Zhang Yu , Tang Jianzhou , Jin Junyan , Li Yaoguo , Zou Jun , Liu Zhen
Published: December 2022

Kidney-type glutaminase, encoded by the gls1 gene, plays a critical role in glutamate production and improvement of meat flavor. In this study, a gls1 gene encoding 595 amino acids was cloned from triploid crucian carp (Carassius auratus) (TCC) and showed a high similarity with the gls1 gene found in Cyprinus carpio, Sinocyclocheilus rhinocerous and Puntigrus tetrazona. Comparing the abundance of gls1 in different tissues, we found its expression level in the brain and liver were significantly higher than that in heart, gut, kidney, spleen and muscle. gls1 expression in the brain reached the highest value. In addition, the expression levels of gls1 also appeared different in diurnal variation, with the highest expression seen at 9:00, while it was low at 3:00, 6:00, 15:00 and 24:00. Furthermore, dietary regulation of gls1 expression was investigated in our study. In each feeding trial, each diet was randomly assigned to triplicate tanks. Fish were fed one of the tested diets up to satiation twice daily. The results showed that gls1 expression increased in 32% protein group and decreased in 35–41% protein group. The results of different protein source experiments showed that the expression of gls1 gene in the mixed protein group (the control group) was significantly higher than that in the fish meal and soybean meal groups. Glutamate treatment revealed that appropriate concentrations (0.10 mg/mL in vivo and 2.00% in vitro) of glutamate remarkably improved the expression of gls1. Besides, diets supplemented with 0.80–1.60% lysine-glutamate dipeptide exhibited a down regulatory impact on gls1 expression. In conclusion, this study demonstrated that the expression of gls1 in TCC was increased by 32% protein diet, mixed protein source diet and diet with 2.00% glutamate concentration, while decreased by 0.80–1.60% lysine-glutamate dipeptide. The findings of this study provide a reference for the regulation of gls1 and have a potential application in the optimization of dietary formula in aquaculture.
Overview of the Observing System and Initial Scientific Accomplishments of the East Asian VLBI Network (EAVN)
Authors: Akiyama Kazunori , Algaba Juan-Carlos , An Tao , Asada Keiichi , Asanok Kitiyanee , Byun Do-Young , Chanapote Thanapol , Chen Wen , Chen Zhong , Cheng Xiaopeng , Chibueze James O. , Cho Ilje , Cho Se-Hyung , Chung Hyun-Soo , Cui Lang , Cui Yuzhu , Doi Akihiro , Dong Jian , Fujisawa Kenta , Gou Wei , Guo Wen , Hada Kazuhiro , Hagiwara Yoshiaki , Hirota Tomoya , Hodgson Jeffrey A. , Honma Mareki , Imai Hiroshi , Jaroenjittichai Phrudth , Jiang Wu , Jiang Yongbin , Jiang Yongchen , Jike Takaaki , Jung Dong-Kyu , Jung Taehyun , Kawaguchi Noriyuki , Kim Dong-Jin , Kim Hyo-Ryoung , Kim Jaeheon , Kim Jeong-Sook , Kim Kee-Tae , Kim Soon-Wook , Kino Motoki , Kobayashi Hideyuki , Koyama Shoko , Kramer Busaba H. , Lee Jee-Won , Lee Jeong Ae , Lee Sang-Sung , Lee Sang Won , Li Bin , Li Guanghui , Li Xiaofei , Li Zhixuan , Liu Qinghui , Liu Xiang , Lu Ru-Sen , Motogi Kazuhito , Nakamura Masanori , Niinuma Kotaro , Oh Chungsik , Oh Hongjong , Oh Junghwan , Oh Se-Jin , Oyama Tomoaki , Park Jongho , Poshyachinda Saran , Ro Hyunwook , Roh Duk-Gyoo , Rujopakarn Wiphu , Sakai Nobuyuki , Sawada-Satoh Satoko , Shen Zhi-Qiang , Shibata Katsunori M. , Sohn Bong Won , Soonthornthum Boonrucksar , Sugiyama Koichiro , Sun Yunxia , Takamura Mieko , Tanabe Yoshihiro , Tazaki Fumie , Trippe Sascha , Wajima Kiyoaki , Wang Jinqing , Wang Na , Wang Shiqiang , Wang Xuezheng , Xia Bo , Xu Shuangjing , Yan Hao , Yang Wenjun , Yeom Jae-Hwan , Yi Kunwoo , Yi Sang-Oh , Yonekura Yoshinori , Yoon Hasu , Yu Linfeng , Yuan Jianping , Yun Youngjoo , Zhang Bo , Zhang Hua , Zhang Yingkang , Zhao Guang-Yao , Zhao Rongbing , Zhong Weiye ,   on behalf of the East Asian VLBI Network Collaboration
Published: December 2022

The East Asian VLBI Network (EAVN) is an international VLBI facility in East Asia and is operated under mutual collaboration between East Asian countries, as well as part of Southeast Asian and European countries. EAVN currently consists of 16 radio telescopes and three correlators located in China, Japan, and Korea, and is operated mainly at three frequency bands, 6.7, 22, and 43 GHz with the longest baseline length of 5078 km, resulting in the highest angular resolution of 0.28 milliarcseconds at 43 GHz. One of distinct capabilities of EAVN is multi-frequency simultaneous data reception at nine telescopes, which enable us to employ the frequency phase transfer technique to obtain better sensitivity at higher observing frequencies. EAVN started its open-use program in the second half of 2018, providing a total observing time of more than 1100 h in a year. EAVN fills geographical gap in global VLBI array, resulting in enabling us to conduct contiguous high-resolution VLBI observations. EAVN has produced various scientific accomplishments especially in observations toward active galactic nuclei, evolved stars, and star-forming regions. These activities motivate us to initiate launch of the ’Global VLBI Alliance’ to provide an opportunity of VLBI observation with the longest baselines on the earth.
Chromium Transport and Fate in Vadose Zone: Effects of Simulated Acid Rain and Colloidal Types
Authors: Zhang Wenjing , Zhao Kaichao , Wan Bo , Liang Zhentian , Xu Wenyan , Li Jingqiao
Published: December 2022

Chromium (Cr) can enter groundwater through rainfall infiltration and significantly affects human health. However, the mechanisms by which soil colloids affect chromium transport are not well investigated. In this study, column experiments were conducted to simulate the chromium (Cr) transport mechanism in two typical soils (humic acid + cinnamon soil and montmorillonite + silt) in the vadose zone of a contaminated site and the effects of acid rain infiltration conditions. The results showed that Mt colloids have less influence on Cr. The fixation of Cr by colloid mainly occurs in the cinnamon soil layer containing HA colloid. The adsorption efficiency of Cr was increased by 12.8% with the addition of HA. In the HA-Cr system, the introduction of SO42− inhibited the adsorption of Cr, reducing the adsorption efficiency from 31.4% to 24.4%. The addition of Mt reduced the adsorption efficiency of Cr by 15%. In the Mt-Cr system, the introduction of SO42− had a promoting effect on Cr adsorption, with the adsorption efficiency increasing from 4.4% to 5.1%. Cr release was inhibited by 63.88% when HA colloid was present, but the inhibition owing to changes in acidity was only 14.47%. Mt colloid promotes Cr transport and increases the leaching rate by 2.64% compared to the absence of Mt. However, the effect of acidity change was not significant. Intermittent acid rain will pose a higher risk of pollutant release. Among the influencing factors, the type of colloid had the most significant influence on the efficiency of Cr leaching. This study guides the quantitative assessment of groundwater pollution risk caused by Cr in the vadose zone.
Development and Psychometric Validation of the Athletes’ Perceived Body Pressures from Coaches Questionnaire (APBPCQ)
Authors: Eck Kaitlyn M. , Byrd-Bredbenner Carol
Published: December 2022

This study aimed to develop a questionnaire to assess male and female athletes’ perceived weight and shape pressure from coaches and establish its psychometric properties. Exploratory factor analysis (N = 412 in each female sample 1 and 2) provided evidence for 4 scales for female athletes and 3 scales for male athletes which were confirmed in confirmatory factor analysis (N = 260 in each male sample 1 and 2). For both females and males, KMO testing and Bartlett’s test of sphericity indicated that the sampling was adequate and survey items were appropriate for factor analysis. Additionally, all scales for both sexes had strong factor loadings (≥0.65), good Cronbach alpha coefficients (>0.70), and made contextual sense. The magnitude of difference results were indicative of a stable factor structure. Goodness-of-fit indicators were all in the expected direction. Good convergent validity was demonstrated. The questionnaire’s excellent psychometric properties and novelty make it a valuable tool for researchers and practitioners. This questionnaire has the potential to identify training needs in coaching staff, as well as to identify athletes who may benefit from support and guidance for effectively coping with pressure from coaches.
The Effectiveness of a Four-Week Online Mindfulness Training Course on Individual Mindfulness Skills and Personal Perception of Stress in Company Employees Working from Home
Authors: Rana Madiha , Bock Lotte , Riedel Erik , Moellmann Henriette , Schorn Lara , Rana Majeed
Published: December 2022

Working from home comes with many benefits. However, employees are often exposed to various stressors when working outside of the traditional workplace environment. The subjective experience of these stressors is related to one’s perception of the situation and the perceived resources available. As working from home has become the new normal for many during the COVID-19 pandemic, it is in the interest of companies to provide employees with tools to cope with these stressors. One such tool is online mindfulness training. This study investigates how a four-week online mindfulness training influences an individual’s mindfulness skills, subjective perception, and processing of stressors. Forty participants working from home at the time of the study were examined in a pre-test using a pre-post design in which the experimental group participated in a four-week online training course in mindfulness. Since the results showed a significantly reduced subjective perception of stress in the experimental group after mindfulness training, a long-term study was conducted including 40 additional participants. The study revealed a training success of at least three months. It thus introduces new possibilities for effective stress management in all workplace settings.
The Carbon Emission Characteristics and Reduction Potential in Developing Areas: Case Study from Anhui Province, China
Authors: Zhang Kerong , Jiang Liangyu , Jin Yanzhi , Liu Wuyi
Published: December 2022

Global warming and world-wide climate change caused by increasing carbon emissions have attracted a widespread public attention, while anthropogenic activities account for most of these problems generated in the social economy. In order to comprehensively measure the levels of carbon emissions and carbon sinks in Anhui Province, the study adopted some specific carbon accounting methods to analyze and explore datasets from the following suggested five carbon emission sources of energy consumption, food consumption, cultivated land, ruminants and waste, and three carbon sink sources of forest, grassland and crops to compile the carbon emission inventory in Anhui Province. Based on the compiled carbon emission inventory, carbon emissions and carbon sink capacity were calculated from 2000 to 2019 in Anhui Province, China. Combined with ridge regression and scenario analysis, the STIRPAT model was used to evaluate and predict the regional carbon emission from 2020 to 2040 to explore the provincial low-carbon development pathways, and carbon emissions of various industrial sectors were systematically compared and analyzed. Results showed that carbon emissions increased rapidly from 2000 to 2019 and regional energy consumption was the primary source of carbon emissions in Anhui Province. There were significant differences found in the increasing carbon emissions among various industries. The consumption proportion of coal in the provincial energy consumption continued to decline, while the consumption of oil and electricity proceeded to increase. Furthermore, there were significant differences among different urban and rural energy structures, and the carbon emissions from waste incineration were increasing. Additionally, there is an inverted “U”-shape curve of correlation between carbon emission and economic development in line with the environmental Kuznets curve, whereas it indicated a “positive U”-shaped curve of correlation between carbon emission and urbanization rate. The local government should strengthen environmental governance, actively promote industrial transformation, and increase the proportion of clean energy in the energy production and consumption structures in Anhui Province. These also suggested a great potential of emission reduction with carbon sink in Anhui Province.
How Do Shifts in Patients with Mental Health Problems’ Formal and Informal Care Utilization Affect Informal Caregivers?: A COVID-19 Case Study
Authors: Bremmers Leonarda G. M. , Hakkaart-van Roijen Leona , Gräler Eleonora S. , Uyl-de Groot Carin A. , Fabbricotti Isabelle N.
Published: December 2022

(1) Background: This study investigated how potential shifts in patients’ formal and informal care utilization during the COVID-19 pandemic impacted their informal caregivers in terms of their subjective burden, psychological wellbeing, and happiness. (2) Methods: A retrospective cohort study design was employed for a panel of Dutch informal caregivers of persons with mental health problems (n = 219) in June 2020. Descriptive statistics and differences between means were determined for the patients’ informal and care utilization and informal caregivers’ subjective burden, happiness, and psychological wellbeing. Three mediation analyses were conducted using the PROCESS macro. (3) Results: Informal caregivers reported significantly worse happiness and subjective burden scores during the COVID-19 pandemic compared with before the lockdown. There were minimal shifts in patient’s care utilization reported, with the exception of a decrease in significant emotional and practical support provided by the informal caregiver. In the mediation analyses, there was not a significant indirect effect of shifts in patients’ formal care utilization on informal caregivers’ subjective burden, psychological wellbeing, and happiness through shifts in patients’ informal care utilization. (4) Discussion and conclusion: Whilst we found that shifts in patients’ care utilization during the first wave of the pandemic did not affect the informal caregiver in the short term, it is unclear what the long-term impact of the pandemic might be on informal caregivers. More research should be conducted to understand the implications of short- and long-term impact of substitution on informal caregivers of persons with mental health problems, with special consideration of the COVID-19 context and uptake of e-health technology.
The Relationship of Neighborhood Walking Behavior to Duration of Aging in Place—A Retrospective Cohort Study
Authors: Wang Zhe , Shepley Mardelle
Published: December 2022

The benefits of physical activity on health are widely known. However, the impact of physical activity on aging-in-place at home for older adults is unclear. Focusing on older adults who recently moved from home to a senior-living facility, this research explored the impact of walking on the ability to age-in-place. Data were collected through a questionnaire survey completed by residents in 12 assisted-living facilities in Houston, Texas. Controlling for significant personal factors, ANOVAs were applied. Non-Hispanic White older adults (N = 124) who used canes or no aids and engaged in 30 min to 1 h of walking per occurrence were able to remain in their homes for an average of 17.84 years after age 65, 1.85 years longer than their counterparts who walked less than 30 min per occurrence. Those who walked for more than an hour per occurrence remained at home for 22.71 years on average, 6.72 years longer than their counterparts (p ≤ 0.05). Engaging in neighborhood walking may help older adults maintain more years of aging-in-place at home. The findings have a direct impact on both public health programs and community design and planning strategies promoting aging-in-place.
Numerical Investigation of Overtopping Prevention for Optimal Safety Dike Design
Authors: Son Namjeong , Kim Yoojin , Min Mimi , Jung Seungho , Kang Chankyu
Published: December 2022

Leakage accidents at chemical facilities have a negative impact on both the environment and human life, and the government has established and implemented regulations on dikes in order to minimize such accidents. However, the overtopping phenomenon in which chemicals overflow the dike due to catastrophic leakage requires additional safeguards. In this study, the mitigation effect was confirmed by simulating tanks and dikes using various deflector plates to minimize the effect of spilled chemicals. ANSYS Fluent 19.1, a computational fluid dynamics program, was used, and the overtopping effect was compared with a dike design that satisfies the safety regulations using a volume of fluid (VOF) model that analyzes multiphase flow through a surface tracking technique. Nitric acid and sulfuric acid were used in the study; they were selected because they are frequently involved in leakage accidents. In the event of a leak in a liquid tank, a dike with a deflector plate was very effective in reducing overtopping, and a deflector at a 45° angle was more effective than a 30° deflector. However, it is necessary to install additional safeguards at the joint between the dike and the deflection plate to withstand the force of the liquid.
Proactive Risk Assessment through Failure Mode and Effect Analysis (FMEA) for Perioperative Management Model of Oral Anticoagulant Therapy: A Pilot Project
Authors: Micheletta Fausta , Ferrara Michela , Bertozzi Giuseppe , Volonnino Gianpietro , Nasso Maria , La Russa Raffaele
Published: December 2022

Introduction: Correct perioperative management of anticoagulant therapy is essential to prevent thromboembolic events and reduce the risk of bleeding. The lack of universally accepted guidelines makes perioperative anticoagulant therapy management difficult. The present study aims to identify the perioperative risks of oral anticoagulant therapy and to reduce adverse events through Failure Mode and Effect Analysis (FMEA). Materials and Methods: A multidisciplinary working group was set up, and four main phases of the process were identified. Each of these phases was divided into micro-activities to identify the related possible failure modes and their potential consequences. The Risk Priority Number was calculated for each failure mode. Results and Discussion: Seventeen failure modes were identified in the entire perioperative period; those with a higher priority of intervention concern the incorrect timing between therapy suspension and surgery, and the incorrect assessment of the bleeding risk related to the invasive procedure. Conclusion: The FMEA method can help identify anticoagulant therapy perioperative failures and implement the management and patient safety of surgical procedures.
Wind and Seismic Response Control of Dynamically Similar Adjacent Buildings Connected Using Magneto-Rheological Dampers
Authors: Baheti Akshay Satishkumar , Matsagar Vasant Annasaheb
Published: December 2022

Wind and/or earthquake-imposed loadings on two dynamically similar adjacent buildings cause vigorous shaking that can be mitigated using energy dissipating devices. Here, the vibration response control in such adjacent structures interconnected with semi-active magneto-rheological (MR) dampers is studied, which could also be used as a retrofitting measure in existing structures apart from employing them in new constructions. The semi-active nature of the MR damper is modeled using the popular Lyapunov control algorithm owing to its least computational efforts among the other considered control algorithms. The semi-active performance of the MR damper is compared with its two passive states, e.g., passive-off and passive-on, in which voltage applied to the damper is kept constant throughout the occurrence of a hazard, to establish its effectiveness even during the probable electric power failure during the wind or seismic hazards. The performance of the MR damper, in terms of structural response reduction, is compared with other popular energy dissipating devices, such as viscous and friction dampers. Four damper arrangements have been considered to arrive at the most effective configuration for interconnecting the two adjoining structures. Structural responses are recorded in terms of storey displacement, storey acceleration, and storey shear forces. Coupling the two adjacent dynamically similar buildings results in over a 50% reduction in the structural vibration against both wind and earthquake hazards, and this is achieved by not necessarily connecting all the floors of the structures with dampers. The comparative analysis indicates that the semi-active MR damper is more effective for response control than the other passive dampers.
Experience of Using DLS to Study the Particle Sizes of Active Component in the Catalysts Based on the Oxide and Non-Oxide Supports
Authors: Larichev Yurii V.
Published: December 2022

The present study reports the use of the dynamic light scattering (DLS) method to analyze metal nanoparticle sizes in supported catalysts (as a model system for different metal-oxide nanocomposites, ceramics, etc.). The selective dissolution of matrices has been used to transform solids to sols for DLS analysis. DLS/STS (from solid to sol) technique was tested on a wide number of different sets of supported metal catalysts (Pt, Pd, Ru metals and Al2O3, SiO2, TiO2, C3N4, carbon and polymers as supports). The transmission electron microscopy and X-ray diffraction (TEM/XRD) results for the initial supported catalysts and the DLS results for the sols prepared from them showed good agreement with each other. Moreover, it has been shown that this approach can identify the minor contamination of catalysts by large particles or aggregates which are difficult to detect by TEM/XRD.
Analysis of Thermo-Hygrometric Conditions of an Innovative Underwater Greenhouse
Authors: Tanda Giovanni , Memme Samuele , Cucchia Gabriele , Gamberini Sergio
Published: December 2022

Nemo’s Garden® Project aims at creating a green, alternative, and original agriculture system based on underwater greenhouses (biospheres) developed for areas where plant growth is difficult in the terrestrial environment due to climate conditions and new global warming issues. Experiments were designed and performed to measure the thermal and hygrometric behaviour inside the biosphere; a simple theoretical model was developed to analyse the temperature and humidity of the air inside the biosphere in dynamic conditions and to interpret the experimental observations. The main findings of this research were: (i) the photosynthetically active radiation measured inside the underwater biosphere was 25–30% of that at sea level, (ii) the air temperature and relative humidity inside the biosphere showed cyclic daily variations that permitted a water evaporation/vapour condensation process, allowing the self-production of water for plant irrigation, and (iii) the results given by the lumped-parameter theoretical model were in a good agreement with the experiments.
Investigating the Performance of the Order-Picking Process by Using Smart Glasses: A Laboratory Experimental Approach
Authors: Chondromatidis Nikolaos , Gialos Anastasios , Zeimpekis Vasileios
Published: December 2022

Background: Order picking process is critical for accurate and efficient order fulfilment. Pick-by-vision is a promising technology that may support order picking process, however there is still a limited amount of research concerning the impact of this technology on the performance of order-picking. The purpose of this paper is to investigate certain operational and technical parameters that affect the performance of pick-by-vision technology in item-level order picking via a series of laboratory tests. Methods: A systematic literature review is conducted for the identification of parameters that affect pick-by-vision performance. Subsequently, the analytical hierarchy process is adopted to rank these parameters, concerning their impact on order picking. Then, the design of experiment and NASA task load index methodology are implemented for assessing pick-by-vision efficiency and perceived workload. Results: The results reveal the parameters that significantly affect the performance of the pick-by-vision system, as well as the best configuration of parameters for the implementation of the proposed system in real environments. Conclusions: The results obtained are encouraging, showing how pick-by-vision technology can support order picking efficiency. Furthermore, practical implications are presented that deal with the organizational culture, process re-engineering, staff resistance to change, and motivation for maintaining the new way of executing order-picking processes.
A Submucosal Tumor-like Lesion of the Cervical Esophagus Similar to the Tonsillar Structures of Waldeyer’s Ring: A Case Report
Authors: Song Shibo , Feng Xiaolong , Liu Xudong , Wang Guiqi , Xue Liyan
Published: December 2022

Esophageal submucosal tumors are rare, but their pathological types are diverse. In addition to the relatively common leiomyomas, some rare submucosal lesions are occasionally reported. Waldeyer’s ring is described as a unique subtype of mucosa-associated lymphoid tissue, located in the naso-oropharynx. Studies have reported that Waldeyer’s ring is the most common site of primary extranodal lymphoma in the head and neck. Interestingly, we encountered an esophageal submucosal tumor-like lesion similar to the tonsillar structures of Waldeyer’s ring. A 38-year-old man underwent esophagoscopy after experiencing swallowing discomfort for 3 months. A protruding submucosal mass with slightly rough mucosa was found at the cervical esophagus approximately 20 cm from the incisors. Considering the possibility of the coexistence of a submucosal tumor and a mucosal lesion, as well as the continuous symptoms of swallowing discomfort, the patient underwent endoscopic submucosal dissection. The lesion was removed en bloc. However, histology revealed a lesion similar to the tonsillar structure of Waldeyer’s ring between the lamina propria and submucosa. The patient was followed up for 6 months without recurrence or complaints. We report a new submucosal lesion and discuss its origin and treatment. Diagnostic ESD might be an effective option until its malignant potential is clarified.
Immersive Virtual Reality during Robot-Assisted Gait Training: Validation of a New Device in Stroke Rehabilitation
Authors: Morizio Charles , Compagnat Maxence , Boujut Arnaud , Labbani-Igbida Ouiddad , Billot Maxime , Perrochon Anaick
Published: December 2022

Background and objective: Duration of rehabilitation and active participation are crucial for gait rehabilitation in the early stage after stroke onset. Virtual reality (VR) is an innovative tool providing engaging and playful environments that could promote intrinsic motivation and higher active participation for non-ambulatory stroke patients when combined with robot-assisted gait training (RAGT). We have developed a new, fully immersive VR application for RAGT, which can be used with a head-mounted display and wearable sensors providing real-time gait motion in the virtual environment. The aim of this study was to validate the use of this new device and assess the onset of cybersickness in healthy participants before testing the device in stroke patients. Materials and Methods: Thirty-seven healthy participants were included and performed two sessions of RAGT using a fully immersive VR device. They physically walked with the Gait Trainer for 20 min in a virtual forest environment. The occurrence of cybersickness, sense of presence, and usability of the device were assessed with three questionnaires: the Simulator Sickness Questionnaire (SSQ), the Presence Questionnaire (PQ), and the System Usability Scale (SUS). Results: All of the participants completed both sessions. Most of the participants (78.4%) had no significant adverse effects (SSQ < 5). The sense of presence in the virtual environment was particularly high (106.42 ± 9.46). Participants reported good usability of the device (86.08 ± 7.54). Conclusions: This study demonstrated the usability of our fully immersive VR device for gait rehabilitation and did not lead to cybersickness. Future studies should evaluate the same parameters and the effectiveness of this device with non-ambulatory stroke patients.
Recent Trends and Developments in Multifunctional Nanoparticles for Cancer Theranostics
Authors: Rabaan Ali A. , Bukhamsin Rehab , AlSaihati Hajir , Alshamrani Saleh A. , AlSihati Jehad , Al-Afghani Hani M. , Alsubki Roua A. , Abuzaid Abdulmonem A. , Al-Abdulhadi Saleh , Aldawood Yahya , Alsaleh Abdulmonem A. , Alhashem Yousef N. , Almatouq Jenan A. , Emran Talha Bin , Al-Ahmed Shamsah H. , Nainu Firzan , Mohapatra Ranjan K.
Published: December 2022

Conventional anticancer treatments, such as radiotherapy and chemotherapy, have significantly improved cancer therapy. Nevertheless, the existing traditional anticancer treatments have been reported to cause serious side effects and resistance to cancer and even to severely affect the quality of life of cancer survivors, which indicates the utmost urgency to develop effective and safe anticancer treatments. As the primary focus of cancer nanotheranostics, nanomaterials with unique surface chemistry and shape have been investigated for integrating cancer diagnostics with treatment techniques, including guiding a prompt diagnosis, precise imaging, treatment with an effective dose, and real-time supervision of therapeutic efficacy. Several theranostic nanosystems have been explored for cancer diagnosis and treatment in the past decade. However, metal-based nanotheranostics continue to be the most common types of nonentities. Consequently, the present review covers the physical characteristics of effective metallic, functionalized, and hybrid nanotheranostic systems. The scope of coverage also includes the clinical advantages and limitations of cancer nanotheranostics. In light of these viewpoints, future research directions exploring the robustness and clinical viability of cancer nanotheranostics through various strategies to enhance the biocompatibility of theranostic nanoparticles are summarised.
Aqueous Rechargeable Zn/ZnO Battery Based on Deposition/Dissolution Chemistry
Authors: Soundharrajan Vaiyapuri , Lee Jun , Kim Seokhun , Putro Dimas Yunianto , Lee Seulgi , Sambandam Balaji , Mathew Vinod , Sakthiabirami Kumaresan , Hwang Jang-Yeon , Kim Jaekook
Published: December 2022

Recently, a novel electrochemical regulation associated with a deposition/dissolution reaction on an electrode surface has been proven to show superiority in large-scale energy storage systems (ESSs). Hence, in the search for high-performance electrodes showcasing these novel regulations, we utilized a low-cost ZnO microsphere electrode to construct aqueous rechargeable batteries (ARBs) that supplied a harvestable and storable charge through electrochemical deposition/dissolution via a reversible manganese oxidation reaction (MOR)/manganese reduction reaction (MRR), respectively, induced by the inherent formation/dissolution of zinc basic sulfate in a mild aqueous electrolyte solution containing 2 M ZnSO4 and 0.2 M MnSO4.
Dissecting Bonding Interactions in Cysteine Dimers
Authors: Gómez Santiago , Gómez Sara , David Jorge , Guerra Doris , Cappelli Chiara , Restrepo Albeiro
Published: December 2022

Neutral (n) and zwitterionic (z) forms of cysteine monomers are combined in this work to extensively explore the potential energy surfaces for the formation of cysteine dimers in aqueous environments represented by a continuum. A simulated annealing search followed by optimization and characterization of the candidate structures afforded a total of 746 structurally different dimers held together via 80 different types of intermolecular contacts in 2894 individual non-covalent interactions as concluded from Natural Bond Orbitals (NBO), Quantum Theory of Atoms in Molecules (QTAIM) and Non-Covalent Interactions (NCI) analyses. This large pool of interaction possibilities includes the traditional primary hydrogen bonds and salt bridges which actually dictate the structures of the dimers, as well as the less common secondary hydrogen bonds, exotic X⋯Y (X = C, N, O, S) contacts, and H⋯H dihydrogen bonds. These interactions are not homogeneous but have rather complex distributions of strengths, interfragment distances and overall stabilities. Judging by their Gibbs bonding energies, most of the structures located here are suitable for experimental detection at room conditions.
Natural Antioxidants, Tyrosinase and Acetylcholinesterase Inhibitors from Cercis glabra Leaves
Authors: Lou Yueyue , Xu Ting , Cao Huaqiang , Zhao Qiuyue , Zhang Pengpai , Shu Penghua
Published: December 2022

Cercis glabra is a plant belonging to the legume family, whose flowers and barks are commonly used as food and traditional Chinese medicines. However, its leaves are usually disposed of as wastes. This research comprehensively investigated the bioactive constituents of C. glabra leaves, and two new phenolic, ceroffesters A-B (1–2) and thirteen known compounds (3–15) were isolated. Their structures were elucidated by spectroscopic methods such as nuclear magnetic resonance (1D NMR and 2D NMR), high-resolution electrospray ionization mass spectra (HR-ESI-MS), optical rotatory dispersion (ORD) and electronic circular dichroism (ECD). All of them were assessed for their antioxidant activities through ABTS, DPPH and PTIO methodologies, and evaluated for inhibitory activities against two enzymes (mushroom tyrosinase and acetylcholinesterase). As a result, compounds 3–6, 10 and 13 exhibited evident antioxidant activities. Meanwhile, compounds 5, 10 and 13 showed the most potent tyrosinase inhibitory activities, with IC50 of 0.64, 0.65 and 0.59 mM, and compared with the positive control of 0.63 mM (kojic acid). In the initial concentration of 1 mg/mL, compounds 3, 5 and 6 demonstrated moderate inhibitory activities against acetylcholinesterase with 85.27 ± 0.06%, 83.65 ± 0.48% and 82.21 ± 0.09%, respectively, compared with the positive control of 91.17 ± 0.23% (donepezil). These bioactive components could be promising antioxidants, tyrosinase and acetylcholinesterase inhibitors.