bluuebunny/crossref_metadata_2025 huggingface dataset:
Pembuatan Alat Penghancur Sampah Infeksius Jenis Popok dan Pembalut Sekali Pakai untuk Optimalisasi Pengelolaan Sampah TPS3R Desa Tanjungrejo
Authors: Afriliana Ryo , Wijaya Chandra Adi , Himawati Iftitah , Iresha Fajri Mulya , Mubarok Husein , Wahyuni Elvira
Published: December 2024

One of the urgent issues worldwide is infectious waste, which impacts both the environment and health. Infectious waste includes various types of medical waste, such as disposable diapers and sanitary pads contaminated with hazardous materials like blood, bodily fluids, and other pathogens. If not properly managed, infectious waste can lead to the spread of diseases. The village of Tanjungrejo, located in the Ngombol subdistrict, has a well-managed TPS3R Waste Bank, but one of the issues they face is the lack of a management method for infectious waste like disposable diapers and sanitary pads. In Tanjungrejo, infectious waste is often disposed of by being dumped into streams or burned along with other waste due to the lack of proper facilities for managing infectious waste. This method of waste management can lead to the transmission of diseases and environmental pollution, such as water, air, and soil contamination. Based on these issues, the aim of this community service project is to develop technologies and innovations to help address environmental problems, including the management of infectious waste. The project will use the Design Thinking method, which includes the stages of empathize, define, ideate, prototype, and test.
Peningkatan Efisiensi dan Pemberdayaan Anggota Melalui Digitalisasi Manajemen Operasional KUBE Mutiara Berkah Abadi
Authors: Azzat Noor Nailie , Mohammad Gunawan , Susila Agus Dwi
Published: December 2024

This community service program aims to improve the operational efficiency of the KUBE Mutiara Berkah Abadi (Joint Business Group) in Krapyak Village, Jepara, through the digitalization of operational management and the design of ergonomic product display racks. The methods used include training, socialization, and mentoring for the implementation of digital technology as well as the design of product display racks. The results showed increased efficiency in transaction recording and inventory management, along with an increase in customer interest due to more attractive product arrangements. Through digitalized management, KUBE can monitor stock and sales in real-time, reducing the risk of lost sales due to insufficient stock or unsold products. This program contributes to empowering KUBE members by enhancing digital skills and product design.
Peningkatan Efisiensi Produksi Pakan dan Keselamatan Kerja di Kelompok Ternak 99 Farm Melalui Implementasi Mesin Pencacah Rumput Hemat Energi
Authors: Worldailmi Elanjati , Annisa Putri Dwi , Wahyuni Elvira Sukma , Masalik Hasan , Fauziyah Nada Putri , Ningtyas Anggun Galuh Puspita
Published: December 2024

The 99 Farm Livestock Group faces challenges in increasing feed production efficiency and occupational safety and health (OHS). These challenges are caused by the use of inefficient and unergonomic grass chopping machines, which pose risks to livestock farmers' safety and increase operational costs. This community service program aims to address these issues by introducing energy-efficient grass chopping machines designed with ergonomic and OHS aspects in mind. This study examines the impact of implementing this technology on livestock farmers' operational efficiency and welfare. The results show a significant increase in the efficiency of the grass chopping process, reduced operational costs, and improved working conditions for livestock farmers. The implementation of this technology is also expected to be an example for other livestock farmers to implement more sustainable and safe practices.
Građanskopravni aspekti politike kontrole oružja
Authors: Pichler Davorin
Published: December 2024

Politiku kontrole oružja formiraju propisi koji nameću neposredna ograničenja različitim oblicima raspolaganja oružjem. Oružje, u smislu stvarnog prava, predstavlja stvar nad kojom određena osoba ima pravo vlasništva koje svojem nositelju daje pojmovno bezgraničnu privatnu pravnu vlast nad stvari. Ograničenja koja pravni poredak nameće vlasniku oružja, u vršenju njegovih vlasničkih ovlaštenja, moraju biti razmjerna naravi potrebe za ograničenjem u svakom pojedinom slučaju. U radu će se istaknuti temeljni oblici kontrole nad posjedovanjem oružja i raspolaganjem oružjem u različitim pravnim sustavima te njihovo opravdanje iz političkih i socijalnih razloga. Analiziraju se građanskopravni aspekti ograničavanja vlasničkih ovlaštenja vlasnika oružja od strane zakonodavne, upravne i sudbene vlasti u Republici Hrvatskoj.
Cancer diagnosis after emergency presentation: impact of demographics, cancer types, and pandemic
Authors: Sosenko Filip , Mair Frances S. , Nicholl Barbara I. , Hanlon Peter , Lewsey Jim , Fleming Michael , Mackay Daniel , Dundas Ruth , Toit Clea Du , Friday Jocelyn , Stevenson Alan , Geue Claudia , Brown Denise , Hastie Claire , Tran Tran Q.B. , Ho Frederick K. , Pell Jill , Padmanabhan Sandosh , Jani Bhautesh Dinesh
Published: December 2024

Importance: Cancer diagnosis following an emergency department presentation (unscheduled care) is associated with lower cancer survival and poor patient-reported outcomes. Previous research has suggested considerable heterogeneity in cancer diagnosis patterns across different health jurisdictions. Objective: We studied cancer diagnosis patterns (diagnosis in scheduled versus unscheduled care) in one of the largest administrative regions in the United Kingdom and examined variations across different demographic groups. Methods: The study sample consisted of all new cancer diagnoses in National Health Service (NHS) Greater Glasgow and Clyde (GGC), which serves 1.2 million people, in 2018, 2019 (before pandemic), 2021, and 2022 (after pandemic). The outcome of interest was cancer diagnosis following an emergency department presentation. Logistic regression was used to assess cross-sectional associations between demographic factors, cancer types, and the outcome. Results: Over a four-year period, N = 40,223 individual new cancer diagnoses were recorded; N = 12,940 cases (32.2%) were diagnosed after an emergency presentation, with a trend toward higher rates in 2021–2022 compared to 2018–2019. People living in areas of high socioeconomic deprivation and those with multiple long-term conditions had higher odds of being diagnosed with cancer after an emergency attendance (unscheduled care). Age had a “J-shaped” relationship with the risk of cancer diagnosis following emergency presentation, with the lowest risk observed between 45 and 60 years. Finally, central nervous system, hematological, and pancreatic cancers were consistently more likely to get diagnosed in unscheduled care than other cancer types. Conclusion: Further research on patient- and healthcare organization-related factors that may contribute to cancer diagnoses in unscheduled care is needed so that potentially modifiable factors can be improved.
PROBLEMATIKA PENGGUNAAN TEKNOLOGI BLOCKCHAIN DI SEKTOR INDUSTRI JASA KEUANGAN INDONESIA
Authors: Putri Livia Azzura , Kharisma Dona Budi
Published: December 2024

This articles aim to identify legal problems in the use of Blockchain technology in the financial services industry in Indonesia. In addition, this study also analyzes the

urgency  of  forming  laws  and  regulations  on  Blockchain  technology  in  the Indonesian financial services industry sector. This type of research is normative legal research. The research approach used in this research is the statute approach. Legal materials used in this research are primary and secondary legal materials. The data collection technique used is literature study. The results showed that Blockchain technology has been utilized in several sectors of the financial services industry in Indonesia. However, the use of Blockchain technology still leaves some room for problems. From the legal aspect, some of these problems include the absence of laws and regulations governing Blockchain, risk and legal issue the using Blockchain technology for Financial Crime and not optimal monitoring of the use of Blockchain technology. This condition certainly creates serious risks related to transaction security, data breaches and monetary system stability. In this regard, the use of Blockchain technology has an urgency to be regulated in the laws and regulations in Indonesia.
The impact of the COVID-19 pandemic on tobacco and alcohol use in the Russian Federation
Authors: Salagay O. O. , Sakharova G. M. , Antonov N. S. , Stadnik N. M. , Nikitina S. Yu.
Published: December 2024

Introduction. The study is devoted to the analysis of the dynamics of the tobacco and alcohol use prevalence among the adult population during the COVID-19 pandemic.

The purpose of the study: to analyze the impact of the COVID-19 pandemic on the prevalence of tobacco and nicotine-containing products consumption among the adult population of the Russian Federation, men and women, as well as diﬀerent age groups.

Materials and methods. The data source for calculations was microdata from the Sample observation of the health status of the population conducted by Rosstat in 2019–2022. The indicators characterizing the prevalence and intensity of tobacco and alcohol use by adults of diﬀerent age groups, men and women, as well as their relative changes in the pre-covid (2019), covid (2020–2021) and post-covid (2022) periods were calculated by the authors.

Results. In 2019–2022, the prevalence of alcohol consumption among the adult population, men and women decreased annually. The largest relative decrease was noted in 2021 and amounted to –5.4% among the adult population, –4.3% among men and –6.1% among women. In 2022, the decline continued and amounted to –1.8%, –0.7% and –2.7%, respectively. In 2021, the maximum decrease in alcohol consumption was detected in the age groups of 15–24 years (–11.0% and –12.2%, respectively), which was replaced by signiﬁcant growth in 2022. A similar trend was found in relation to the prevalence of tobacco/ nicotine use. During 2020–2021, a decrease in the intensity of alcohol and tobacco use was noted.

Conclusion. In general, the COVID-19 pandemic did not aﬀect the general trends in reducing tobacco and alcohol use among the adult population. The changes in the dynamics of their use (decrease) were temporary and were probably related to both health concerns and restrictions imposed during the pandemic period.
Gamificación para dinamizar el clima de aula en física y química en zonas desfavorecidas
Authors: Rodríguez-Ferrer José M. , Manzano León Ana
Published: December 2024

Dada la importancia de estrategias pedagógicas efectivas en contextos de deprivación sociocultural, este estudio explora la gamificación para mejorar el clima de aula en institutos de zonas en riesgo de exclusión social. Se empleó un diseño cuasiexperimental con 216 estudiantes de secundaria, donde se compararon un grupo experimental que participó en siete sesiones gamificadas y un grupo control con enseñanza tradicional. Los resultados revelaron que los estudiantes del grupo experimental mostraron un aumento en la satisfacción, cohesión y orden, con variaciones significativas en la cohesión y la relación entre pares en comparación al grupo control. Los resultados subrayan la eficacia de la gamificación para mejorar el ambiente educativo en contextos desafiantes. Sin embargo, se discute que la variabilidad en la respuesta de los estudiantes sugiere que otros factores adicionales pueden influir en la efectividad de la gamificación.
Between Tradition and Innovation: Transformations in Wind Music in the Slovácko Region since the Early 20th Century
Authors: Turčanová Barbora
Published: December 2024

In the Moravian region of Slovácko, wind music occupies a special position, which has been influenced by a number of factors. At the time of its introduction into the rural environment, bringing with it modern contemporary elements, the discourse of authenticity was beginning to grow stronger in the field of ethnographic science. A few decades later, this construct of originality and ancientness became a factor that paradoxically contributed to the development of wind bands in this environment. This study describes the complex relationships between traditional music and its performance and repertoire development in the context of the long-standing discourse of authenticity in Czech folklore studies and the so-called folklore revival movement.
Jurjevanje Festival from Ritual to Festival
Authors: Pisk Marjeta , Kunej Rebeka
Published: December 2024

The article seeks to provide insight into the process of establishing Slovenia’s oldest folklore festival named Jurjevanje in the town of Črnomelj through a discursive approach. Focused on the Zeleni Jurij (Green George) ritual as the basis of the festival, the article captures the local discourse and explores the festival’s historical development and its connection to broader folklore festivalisation in Slovenia. Key events in the 1930s related to various folklore events and festivals at that time within the region and outside it played pivotal roles. After the Second World War, Črnomelj attempted to revive regional folklore by hosting folk dance group displays, resulting in the emergence in 1964 of the Jurjevanje festival, which blended socialist ideology with heritage preservation. Today, it embodies heritage, identity, and development goals, showcasing the marketability of regional traditions globally.
Unusual Alliance: Renal Cell Carcinoma Metastasis Coalesces with Meningioma – A Unique Case Study
Authors: Oommen Githa Rachel , Ahmad Sadaf , S Annapurneswari
Published: December 2024

Introduction:
The occurrence of tumor-tumor metastasis (TTM) - the spread of one tumor to another - is extremely uncommon in clinical practice. In tumour-tumour metastasis (TTM), a main tumour functions as the recipient tumour, while a different tumour functions as the donor tumour. Meningioma is the most frequent benign tumour to house a metastasizing malignancy, making up 36% of intracranial tumours.
Case report:
The patient is a 75-year-old male who presented with 5 episodes of GTCS associated with difficulty in walking. There is no history of headache and vomiting. MRI brain showed right frontal SOL, and an FDG PET CT scan showed it as a metabolically active solid-cystic hemorrhagic lesion. Microscopy revealed a neoplasm with two distinct histological components composed of nests and sheets of cells with vesicular nuclei and clear cytoplasm on the one hand and a whorled tumour with nuclear pseudo inclusions on the other. On Immunohistochemistry, the neoplastic clear cells were positive for CK, CD10, CA-9, Vimentin, and AMACR revealing its renal origin.
Discussion
There are not many instances of tumor-to-meningioma metastases, and there's no set standard of care. Surgical excision appears to be the most common option, occasionally followed by chemotherapy and postoperative radiation.
Conclusion
Tumor-to-tumor metastasis is an uncommon condition that doctors should be aware of. An original extracranial tumour with a positive history should elevate the possibility of tumour-to-tumour spread.
Identification of Biomarkers and Mechanisms for Keloid Disorder based on Comprehensive Bioinformatics Analysis and Machine Learning Algorithms
Authors: Zheng Bowen , Qiao Jianxiong , Yu Xiaoping , Zhou Hanghang , Wang Anqi , Zhang Xuanfen
Published: December 2024

Background
Keloid disorder (KD) is a group of fibroproliferative skin disorders characterized by hypervascularity and excessive accumulation of the extracellular matrix (ECM) and affects individuals of all age groups. The etiology of KD is complex and still poorly understood. This study aimed to investigate biomarkers and therapeutic targets in KD on the basis of comprehensive bioinformatics analysis and machine learning of RNA autosequencing data.
Methods
Thirteen skin tissues from KD patients (KD samples) and 14 normal control skin tissues (control samples) were collected for RNA sequencing. Initially, differentially expressed key module genes were acquired through expression analysis with weighted gene coexpression network analysis, followed by enrichment analysis. The 10 candidate genes obtained via the CytoHubba plugin were subsequently incorporated into the least absolute shrinkage and selection operator (LASSO) and support vector machine recursive feature elimination (SVM-RFE) to recognize feature genes associated with KD. Furthermore, biomarkers were determined via expression level analysis, followed by enrichment analysis and immunoinfiltration analysis to elucidate the pathogenesis of KD.
Results
A total of 420 differentially expressed key module genes were identified, and these 420 genes were enriched in collagen- and bone-associated biological functions, including “collagen fibril organization” and “bone development”. With respect to the 10 candidate genes, five feature genes were subsequently obtained through LASSO and SVM-RFE, and among them, NID2, MFAP2, COL8A1, and P4HA3 had significant expression differences between the KD and control samples as well as consistent expression patterns in both datasets; these genes were considered biomarkers. These four biomarkers had excellent abilities to diagnose KD patients, and there were significant positive correlations between these four biomarkers. Functional enrichment analysis suggested that the main enriched KEGG pathways for biomarkers were “steroid hormone biosynthesis”, “cytokine–cytokine receptor interaction”, etc. Furthermore, immune analysis suggested that four biomarkers were negatively linked to type 17 T helper cells and positively linked to 15 immune cells (activated B cells, central memory CD4 T cells, etc.).
Conclusion
NID2, MFAP2, COL8A1, and P4HA3 were identified as biomarkers for KD, providing more targeted and effective diagnostic and therapeutic strategies for KD.
On-site quantitative detection of fentanyl in heroin by machine learning- enabled SERS on superabsorbing metasurfaces
Authors: Zhu Yingkun , Song Haomin , Liu Ruiying , Mu Yunyun , Gedda Murali , Alodhay Abdullah N. , Ying Lei , Gan Qiaoqiang
Published: December 2024

The global surge in opioid misuse, particularly fentanyl, presents a formidable public health challenge, highlighted by increasing drug-related mortalities. Our study introduces a novel approach for on-site quantitative detection of fentanyl in heroin, employing machine learning-enabled surface-enhanced Raman spectroscopy (SERS) on superabsorbing metasurfaces. The metasurface enables superior light absorption (> 90%) across a broad wavelength range (580–1100 nm). This architecture facilitates significant electromagnetic field enhancement, over 2.19 × 107, ensuring high sensitivity, uniformity, and reproducibility. Our method precisely captured SERS signals across a detection range of 1 to 100 µg/mL in fentanyl solutions, fentanyl-heroin mixtures, and fentanyl-spiked saliva, demonstrating its versatility and practical utility. Incorporation of partial least squares regression into our analysis achieved over 93% accuracy in concentration predictions, eliminating the need for pre-data processing or specialized personnel. This marks a key advancement in rapid, accurate fentanyl detection, aiding the fight against the opioid crisis and improving public health safety.
Asymptomatic compensatory overload in haemophilia patients is visualized as “vertical” and “diagonal” patterns in deep learning-based surface temperature analysis
Authors: Mawarikado Yuya , Sakata Asuka , Shima Midori , Hosoda Chihiro , Matsumoto Naoki , Kawasaki Ryohei , Ogiwara Kenichi , Furukawa Shoko , Shimonishi Naruto , Soeda Tetsuhiro , Tatsumi Kohei , Inagaki Yusuke , Kido Akira , Nogami Keiji
Published: December 2024

Background: Haemophilia is a bleeding disorder caused by deficiencies in factor VIII or IX, leading to bleeding in deep tissues and haemophilic arthropathy (HA). Surgical treatments like synovectomy or joint replacement can alleviate symptoms but often result in severe pain. Secondary injuries may occur in non-affected body parts due to compensatory overloading. This study explores using infrared thermography (IRT) to monitor whole-body surface temperatures in haemophilia patients to detect early signs of overload and prevent further injury by visualizing compensatory load distribution.
Methods: A descriptive cross-sectional study was conducted involving 24 haemophilia participants aged 6-76 years, experiencing pain after active bleeding, after orthopaedic surgery, or with HA. Thermal images were captured using IRT and analysed with deep learning for whole-body mapping and temperature comparison between symmetrical body regions.
Results: Temperature increases indicating overload were observed in body areas ipsilateral (vertical pattern) or contralateral (diagonal pattern) to the painful site. These patterns were detected in 13 of 14 participants with HA, all participants after orthopaedic surgery, and 5 of 6 participants with active bleeding.
Conclusion: The temperature increases, which may reflect the physical load, occurred in areas other than the painful area. When PwH present with pain, the surrounding area, especially in the diagonal and/or vertical position, may be under strain, even if it is asymptomatic, and requires careful observation and treatment. Our findings may be useful not only for supporting the diagnosis of haemorrhage and local inflammation but also for supporting such treatment decisions.
The Accessory Protein ORF3a Hijacks CLCC1 Chloride Channel to Cause ER Dysfunction in Beta-coronavirus Pathogenesis
Authors: guo liang , Huang Baoying , Yu Hanzhi , Xu Yi , Wei Lei , zheng Jijie , li yuanzhe , Wu Di , Zhao Peng , Wu Changcheng , Tan Wenjie , Jia Yichang
Published: December 2024

The endoplasmic reticulum (ER) homeostasis is crucial for host cells and is influenced by beta-coronaviruses upon invasion. However, the mechanisms by which viral proteins interact with ER-resident host factors to modulate ER functions and morphology remain poorly understood. The accessory protein ORF3a of SARS-CoV-2 plays a pivotal role in viral pathogenesis and modulating host immune responses. The ER-localized chloride channel CLCC1 has been identified as a strong interaction partner of ORF3a, yet the consequences of this interaction are not fully elucidated. Here, we demonstrate that ORF3a interacts with CLCC1 to modulate ER ion homeostasis, including increased ER luminal [Cl−], [K+], and decreased ER [Ca2+], and to trigger unfolded protein responses. The ORF3a-CLCC1 interaction is linked to ER phagy and nucleophagy, monitored by newly developed ratiometric reporters. Mechanistically, ORF3a induces the formation of endogenous CLCC1 puncta, while overexpression of CLCC1 attenuates ORF3a-associated toxicity by sequestering ORF3a within the ER. Furthermore, the conservation of ORF3a functions across beta-coronaviruses suggests it is a potential therapeutic target and uncovers ORF3a-mediated phenotypes spatiotemporally. In addition, ORF3a expression in mouse brains causes ER stress, ER phagy, nucleophagy, and endomembrane reorganization, shedding light on the neurological manifestations and long-term effects observed in COVID-19 patients.
Anxiety and Depressive Symptoms Among Clinical Physiotherapy Students Following Prolonged Lecturers Strike in a Sub-Haran University
Authors: Okonkwo Uchenna Prosper , Udechukwu Ray-Thelma Chisonyerem , Amaechi Ifeoma Adaigwe , Mbanuzuru Ahoma Victor , Okafor Christiana Nkiru , Tamu John Bosco Munezero , Daniel Jovita Ada
Published: December 2024

Objectives
To determine the prevalence of anxiety, and depressive symptoms among clinical physiotherapy students of Nnamdi Azikiwe University following the prolonged lecturers (teachers) strike in 2022.
Methods
This cross-sectional survey consecutively recruited 131 physiotherapy undergraduates of Nnamdi Azikiwe University, in clinical classes. The research instruments were a socio-demographic questionnaire and the Hospital Anxiety and Depression Scale (HADS). Data was analysed using descriptive statistics and a Chi-square inferential statistical test at an alpha level 0.05.
Results: The majority of the participants were between 18-23 years of age, 75 (57.25%) of the participants were in their fourth year of study (400 level), while 56 (42.75%) of the participants were in their fifth year of study (500 level). The prevalence of anxiety and depression within the population of the study were 20.6% and 4.6% respectively. There was a significant association between the pairs of anxiety symptoms and gender (p=0.017); depressive symptoms and gender (p=0.008), with members of the male gender presenting more significant cases of anxiety and depressive symptoms.
Conclusion
The prevalence of depression and anxiety within the population of study were relatively high, and actively associated with gender.
A machine learning-based severity stratification tool for High altitude pulmonary edema
Authors: Gesang Luobu , Suona Yangzong , Danzeng Zhuoga , Ci Bai , Gesang Quzhen , Cidan WangJiu , Dingzeng Qiangba , Baima Zhuoga , Zhaxi Quzhen
Published: December 2024

This study aimed to identify key predictors for the severity of High Altitude Pulmonary Edema (HAPE) to assist clinicians in promptly recognizing severely affected patients in the emergency department, thereby reducing associated mortality rates. Logistic regression, random forest, and decision tree methods were utilized to determine important predictor variables and evaluate model performance. A total of 508 patients diagnosed with HAPE were included in the study, with 53 variables analyzed. Lung rales, sputum coughing, heart rate, and oxygen saturation were identified as the most relevant predictors for the LASSO model. Subsequently, logistic regression, decision tree, and random forest models were trained and evaluated using these factors on a test set. The random forest model showed the highest performance, with an accuracy of 77.94%, precision of 70.27%, recall of 68.22%, and F1 score of 68.96%, outperforming the other models. Further analysis revealed significant differences in predictive capabilities among the models for HAPE patients at varying severity levels. The random forest model demonstrated high predictive accuracy across all severity levels of HAPE, particularly excelling in identifying severely ill patients with an impressive AUC of 0.86. The study assessed the reliability and effectiveness of the HAPE severity scoring model by validating logistic regression and random forest models. This study introduces a valuable screening tool for categorizing the severity of HAPE, aiding healthcare providers in recognizing individuals with severe HAPE, enabling prompt treatment and the formulation of suitable therapeutic approaches.
Detection of Myocardial Infarction by Non-ECG Gated, Contrast-Enhanced CT: Initial Experience
Authors: Zhou Jia‐Hao , Wu Meng-Yu , Hsiao Jong-Kai
Published: December 2024

Coronary heart disease is a leading cause of death in developed countries. While ECG-gated coronary CT is commonly used to detect coronary artery stenosis, the role of non-ECG-gated CT (NECE-CT) in detecting myocardial infarction (MI) remains underexplored, particularly in emergency settings where rapid diagnosis is crucial. This study retrospectively analyzed 22 suspected MI patients from the emergency department who underwent NECE-CT without an initial diagnosis of AMI or available cardiac enzyme or ECG data. Acute MI was confirmed in 45% (n = 10) of patients, with 30% (n = 3/10) showing elevated troponin-I levels only after the CT exam. In the MI group, all patients had perfusion defects, with 20% (n = 2) showing transmural defects and 80% (n = 8) showing endocardial defects. In contrast, all patients in the non-MI group exhibited endocardial defects. Coronary artery calcification was significantly higher in the MI group (70%) compared to the non-MI group (25%, p < 0.05). These findings suggest that NECE-CT can reliably detect MI, with some cases being diagnosed earlier than with standard methods. Further prospective studies are needed to confirm its efficacy in early MI detection.
Enhancing Nutritional Health and Patient Satisfaction Five Years After Metabolic Bariatric Surgery with Targeted Supplementation
Authors: Gorini Stefania , Camajani Elisabetta , Franchi Arianna , Cava Edda , Gentileschi Paolo , Bellia Alfonso , Karav Sercan , Sbraccia Paolo , Caprio Massimiliano , Lombardo Mauro
Published: December 2024

Thisstudy aims to analyze the long-term outcomes of metabolic bariatric surgery (MBS), focusing on weight loss, nutritional deficiencies, and patient satisfaction, by evaluating different surgical techniques. We conducted a five-year retrospective analysis of 249 patients who underwent MBS at a specialized center. The overall sample had an average age of 38.5 years, weight of 118.5 kg, and BMI of 43.2 kg/m². The mean excess weight loss (%EWL) at 60 months was 92.1% ± 25.8% (p = 0.013). Laparoscopic sleeve gastrectomy (SG) and one anastomosis gastric bypass (OAGB) showed similar weight loss patterns, while Roux-en-Y gastric bypass (RYGB) demonstrated further weight reduction from the third year onwards. Patients revised from LSG to RYGB had significantly greater weight loss (102.1%) compared to those revised to MGB (84.6%, p < 0.05). Nutritional deficiencies persisted, with 41.2% of revised LSG patients experiencing iron deficiency and 14.3% developing new vitamin D deficiencies (p < 0.05). Most patients (85%) reported improvements in quality of life, and 85% expressed a willingness to undergo surgery again (p = 0.0028). Our results highlight the link between surgical revisions and increased supplement use, with persistent iron and vitamin D deficiencies. While MBS led to substantial and sustained weight loss, especially in RYGB patients, revisions, particularly from LSG to RYGB, were associated with greater weight loss but also higher nutritional risks. These results emphasise the importance of individualised supplementation and long-term monitoring after the intervention. Type-targeted supplementation represents an innovative strategy in long-term nutritional support for bariatric patients. Future studies on larger cohorts and with validated tools could confirm these results and strengthen clinical guidelines for optimising nutritional health. This paper has been registered to ClinicalTrial.gov (NCT06664580).
Symptoms in Oral Cancer within End of Chemoradiotherapy: A Factor and Cluster Analysis
Authors: Zhang Jiarou , Guo Yulai , Zheng Yu , Li Zijun , GAO JI , Zheng Xiaoyan
Published: December 2024

Objectives
To explore the symptom classification of oral cancer patients within 24 hours of the end of chemoradiotherapy using factor analysis combined with cluster analysis.
Methods
A questionnaire was administered to oral cancer patients in China, and the frequency of all symptoms was calculated, and the main symptom information was included in a factor analysis matrix (rotated) to extract the common factor, which was then used as a variable for systematic cluster analysis.
Results
A total of 5 male factors were screened by factor analysis, with a cumulative contribution rate of 62.691%, excluding the symptom of constipation; they were classified into 3 categories by cluster analysis, corresponding to the 3 symptom clusters.
Conclusion
Symptoms of oral cancer patients within 24 hours of the end of chemoradiotherapy were classified into three groups: radiotherapy side-effect symptom group, salivary-psycho-emotional symptom group, and dysphagia symptom group, each with its own characteristics, of which dysphagia was the most important symptom, which provided new ideas for healthcare professionals to formulate a personalized treatment plan for the patients by identifying each type of symptom group.
Enhanced Photocatalytic Performance of Non-stoichiometric WO 3-x Nanocrystals Via Near-Infrared Localized Surface Plasmon Resonance
Authors: Zafari Mohsen , Tehrani Fatemeh Shariatmadar
Published: December 2024

The use of non-stoichiometric metal oxides as cheaper and abundant plasmonic materials is an effective way to increase photocatalytic performance. This report shows that WO3-x nanocrystals exhibit a localized surface plasmon resonance (LSPR) band in the near-infrared (NIR) and photocatalytic activity towards the degradation of methylene blue (MB). In this report, the LSPR absorption spectrum was simulated using the Mie-Gans theory, and free carrier density (Ne) was calculated. Our findings show that increasing the aspect ratio after calcination shifts the LSPR peak from 1213 to 1771 nm (a remarkable redshift at about 560 nm). In addition, we found that the calcination process leads to the values of Ne as high as 2.03 ×1022 cm–3, which is close to that of plasmonic noble metals, and thus our oxide-based nanostructures can be considered as quasi-metallic. Furthermore, the photodegradation rate of W1.5NC for MB was 0.01228 min-1, about 6.3 times higher than that of W3. This shows that the high photocatalytic performance of W1.5NC can be attributed to the significant enhancement of electron-hole pair generation and separation due to localized surface plasmon resonance. Finally, based on photoluminescence (PL) spectroscopy, we proposed a light-harvesting mechanism for WO3-x nanocrystals.
Exploratory Study of Fall Event Recording in Patients with Knee Osteoarthritis using Clinical Practice Research Datalink and Hospital Episode Statistics Linked Data
Authors: Taqi Aqila , Gran Sonia , Knaggs Roger David
Published: December 2024

Objective
The present study explored fall recording in primary care data and in primary- secondary care linked data, to inform the data source adequacy for examining the association between analgesic use and the risk of falls in patients with knee osteoarthritis (KOA).
Method
Data were obtained from the clinical practice research datalink (CPRD) and Hospital Episode Statistics (HES). The study population included adults with an incident diagnosis of KOA recorded in CPRD between 2000 and 2014. The study captured the proportion of fallers in CPRD, HES or both and measured the gap between fall recording in both databases. Descriptive statistics were used report study measures
Results
There were 104,082 patients diagnosed with KOA in CPRD standalone data; 3,275 (3.1%) of them had a fall while HES-linked data included 57,383 and 2,384 (4.1%) of them had a fall recorded within one year of KOA diagnosis. Among the linked population, 1,852 (3.2%) had a fall record only in CPRD; however, there were an additional 365 (0.6%) patients who had a fall recorded only within HES data, while167 (0.3%) patients had it recorded in both databases. There was a median of 19.5 days’ difference (IQR 4.5, 91) in fall recording between primary and secondary care data.
Conclusion
CPRD records included 84.7% of the overall falls experienced by patients within one year of their KOA diagnosis. However, 15.3% of the falls were only recorded in hospital data; although not a substantial proportion, this represents a group that probably suffered a serious event.
Is muscarinic receptor agonist effective and tolerant for schizophrenia? A systematic review and meta-analysis
Authors: Guo Xiaonan , Deng Rongshan , Lai Jianbo , Hu Shaohua
Published: December 2024

Background:
Several randomized clinical trials (RCTs) have recently examined the efficacy and tolerability of muscarinic receptor agonists in schizophrenia. However, whether therapeutics targeting muscarinic receptors improve symptom management and reduce side effects remains systemically unexplored.
Methods:
Embase, PubMed, and Web of Science were searched from inception until May 16, 2024. Altogether, the efficacy and safety outcomes of four RCTs (397 individuals in the muscarinic receptor agonists group, and 374 in the placebo control group) were meta-analyzed. To compare scores of positive and negative syndrome scale (PANSS), response rate, discontinuation rate, and adverse events with muscarinic receptor agonists vs placebo in patients with schizophrenia, scale changes were pooled as mean difference (MD) for continuous outcomes and risk ratio (RR) for categorical outcomes.
Results:
It revealed that muscarinic receptor agonists were superior to placebo in terms of decrease in the total PANSS score (MD, − 9.92; 95% CI, -12.46 to -7.37; I2 = 0%), PANSS positive symptom subscore (MD, − 3.21; 95% CI, -4.02 to -2.40; I2 = 0%), and PANSS negative symptom subscore (MD, -1.79; 95% CI, -2.47 to -1.11; I2 = 48%). According to the study-defined response rate, the pooled muscarinic receptor agonists vs placebo RR was 2.08 (95% CI, 1.59 to 2.72; I2 = 0%). No significance was found in the discontinuation rate. Muscarinic receptor agonists were associated with a higher risk of nausea (RR = 4.61, 95% CI, 2.65 to 8.02; I2 = 3%), and in particular, xanomeline-trospium was associated with risks of dyspepsia, vomiting, and constipation.
Conclusions:
The findings highlighted an efficacy advantage with tolerated adverse event profiles for muscarinic receptor agonists in schizophrenia.
Functional Outcomes and Return to Sport Following Arthroscopic Surgery for Femoroacetabular Impingement in Rugby Union Players
Authors: Portet Adrien , Lambrey Pierre-Jean , Souberou Lebenin , Hager Jean-Philippe , Thaunat Mathieu
Published: December 2024

Purpose: Femoroacetabular impingement (FAI) is a common cause of hip pain and decreased quality of life among athletes, particularly in sports involving multidirectional movements. Despite its prevalence, there is a lack of specific studies on the outcomes of FAI surgery in rugby union players (RUP). To analyze the functional results and return to sport (RTS) after arthroscopic surgery in RUP suffering from FAI.
Methods: This before/after cohort study included RUP under 35 years who underwent primary hip arthroscopy for FAI. Data collected included demographic information, rugby level, type of FAI, and radiographic arthritis stage. Functional outcomes were measured using various scores, including Harris Hip Score (mHHS), Non-Arthritic Hip Score (NAHS), IHOT-12, Tegner Activity Scale (TAS), and Pain on Visual Analog Scale (VAS). Statistical analysis was performed to compare scores pre- and post-operatively and identify factors associated with return to rugby.
Results: Forty-six hips in 36 patients were analyzed. At a mean follow-up of 3.9 years, significant improvements were observed in all functional scores, except the TAS. mHHS improved by +21.8 points, and the IHOT-12 by +46.1 points. 41% of patients returned to their previous or higher level of rugby, 46% resumed rugby at a lower level, and 13% ceased playing. Age, preoperative sports level, symptom duration, and radiographic arthritis stage were significant factors for partial resumption or cessation of rugby.
Conclusion: Arthroscopic surgery for FAI in RUP yields satisfactory functional outcomes. However, factors such as age, preoperative sports level, symptom duration, and radiographic arthritis stage significantly influence the likelihood of RTS.
Study design: Level IV, Retrospective cohort study
Hazelnut Classification and Weight Estimation
Authors: Kadirhanoğulları İbrahim Hakkı , GÜLSOY Ersin , GÜLBE Alper
Published: December 2024

Hazelnut is a nutritious and delicious nut that is consumed fondly. Hazelnuts also stand out with their economic value. Traditional methods have long been used to classify hazelnuts. However, these methods are time consuming, costly and require expertise. Today, using image-based deep learning classifiers to automatically classify hazelnut varieties can provide significant advantages in agricultural activities. It can increase the productivity of agricultural products. The main objective of this study is to classify hazelnut varieties and make weight estimation using artificial neural networks (ANN). In the study, a data set was created by collecting a total of 700 photo samples from five different hazelnut varieties, namely Çakıldak, Koca kulak, Palaz, Yağlı and Yomra. Then, a new and novel artificial neural network model was developed. The neural network model achieved 100% success in the classification of hazelnut varieties and 72% success in weight prediction. These results demonstrate the potential of artificial intelligence applications in agriculture. In future studies, it is recommended to test different artificial intelligence algorithms for classification and weight estimation of different agricultural products.
Anthropometrics, Cancer Risks, and Survival Outcomes in Adult Patients with Glioma – A Systematic Review and Meta-analysis
Authors: Ahn Jaehyun , Kim Joonseok , Shin Christopher , Ahn Stephen
Published: December 2024

Background
The association between anthropometric measures, including height and BMI, and cancer has been widely discussed, but their role glioma development and survival remains unclear due to conflicting evidence. We synthesized existing data on the relationship between these measures and both the incidence and survival outcomes of glioma patients.
Methods
Papers reporting relationship between anthropometric measures and the risk of glioma, both incidence and survival, were regarded as relevant. All relevant papers published until January 31, 2024, were selected from PubMed, EMBASE, and the Cochrane Library. Studies were evaluated according to the modified Newcastle Ottawa Scale. Results were reported following the PRISMA reporting guideline. Hazard ratios, relative risks, and 95% confidence intervals were pooled and synthesized.
Findings
Among 940 screened articles, 23 were included. Taller height was associated with increased glioma (HR per 10 cm, 1.19; CI, 1.16 to 1.23) and glioblastoma risk (HR per 10 cm, 1.25; CI, 1.18 to 1.31). Higher BMI correlated with an increased glioma risk, both in categorical (RR, 1.08; CI, 1.03 to 1.12) and continuous measures (HR per 5kg/m2, 1.01; CI, 1.00 to 1.03). Glioblastoma demonstrated a higher incidence (HR per 5kg/m2, 1.02; 95% CI 1.00 to 1.05) and improved survival (HR 0.75; 95% CI 0.59 to 0.96) with increasing BMI.
Interpretation
This study synthesizes current evidence to provide critical insights into the relationship between glioma and anthropometric measures. Gliomas were influenced by these measures in terms of incidence and survival. Further research is necessary to uncover the underlying mechanisms and develop preventative or therapeutic strategies.
Reliability of intraoral scanning for capturing gingival morphology and color in periodontitis patients
Authors: Li Linlin , Li Wei , Huang Shengyuan , Dai Dong , Zhao Jing , Lin Jiang
Published: December 2024

Background: To evaluate the reliability of intraoral scanning for recording the morphology and color of gingival tissues in the anterior teeth region of periodontitis patients.
Methods: Direct and indirect digital maxillary models of ten periodontitis patients were acquired by an intraoral scanner (IOS) and a conventional impression (CI), respectively. Superimposition of the digital models was performed to calculate the 3D deviation of the gingival tissues of the anterior teeth between pairwise digital models. Color values (L*a*b*) were recorded at thirteen anterior gingival sites, and the color differences (ΔE*) were calculated. Precision was analyzed using paired-samples t-test, color precision with Mann-Whitney U test, and ΔE among different points with one-way ANOVA.
Results: The IOS demonstrated a significantly lower 3D deviation (42.5 ±17.9 μm) compared to CIs (105.3 ±40.8 μm) (R=.001). The overall ΔE* was 5.69 ±2.63. The ΔE values of the gingival margins and middle gingival tissue were 6.24 ±2.62 and 5.07 ±2.46, respectively, and a significant difference was found (R=.009). The ΔE* values of different points were not equal.
Conclusions: Intraoral scanning provides a highly reliable representation of the gingival morphology of periodontitis patients. The precision of the IOS to reproducecolor information of the middle gingival tissue is better than that of the gingival margins.
Trial Registration ID: ChiCTR2200058275
Intraoperative Diabetes Insipidus as a Potential Risk Factor for Postoperative Complications in Moyamoya Disease：A Retrospective Observational Study
Authors: Lu Jia , Chen Qian , Zhang Xin , Li Yanjiang , Yang Shaoxuan , Jiang Hanqiang , Ni Wei , Gao Chao , Lei Yu , Zhang Jie , Gu Yuxiang
Published: December 2024

Background Surgical revascularization is a potent therapy for moyamoya disease. Despite its efficacy, it carries risks like postoperative stroke and hyperperfusion syndrome, the pathogenesis of which remains elusive. Our clinical observations have indicated a propensity for patients to exhibit intraoperative polyuria and electrolyte disturbances, phenomena suggestive of diabetes insipidus(DI). This study aims to uncover latent risk factors in the context of moyamoya disease and to evaluate the predictability of DI.Measurements Data were retrospectively collected from November 2019 to December 2022 .A total of 273 surgical procedures ( 273 hemispheres)were consecutively reviewed. Univariate analysis and multivariable logistic regression were used to identify if DI was an independent risk factor for the development of postoperative complications within a 30-day period. Subsequently, the risk factors associated with DI were identified utilizing both univariate and multivariable logistic regression analyses. Ultimately, a predictive model for DI was formulated, and a nomogram was constructed to serve as a visual adjunct for clinical application.Results Within a 30-day postoperative period,106 cases (42.4%) manifested hyperperfusion syndrome, while 20 cases (8.0%) suffered postoperative stroke. A total of 113 cases (45.2%) exhibited intraoperative DI, with 67 of these cases subsequently developing postoperative complications. Cases presenting with intraoperative DI had a significantly higher rate of postoperative complications compared to those without this condition (p = 0.02). Subsequent multivariate logistic regression analysis identified intraoperative DI (p = 0.011), elevated Body Mass Index (BMI) (p = 0.032), and ischemic primary disease type (p = 0.015) as independent risk factors for postoperative complications. Furthermore, the same regression analysis revealed that high BMI was a risk factor for intraoperative DI. The area under the curve (AUC) for the model was 0.798..Conclusions Our study delineates that intraoperative DI, high BMI, and ischemic primary disease type are significant risk factors for postoperative complications following surgical revascularization in patients with moyamoya disease. Furthermore, a high BMI was found to be associated with intraoperative DI, suggesting a predictive relationship.Trial registration NCD02305407
Glioblastoma Multiforme Incidence Is Increasing: An Epidemiological Investigation of 100,000 Cases Across the United States
Authors: Sarwar Syed A. , Maddali Anirudh , Adams David , Kumar Rohit Prem , O’Malley Geoffrey R. , Szymanski Linda J. , Goldstein Ira , Patel Nitesh V.
Published: December 2024

Purpose
Glioblastoma Multiforme (GBM) is the most lethal brain tumor, yet few studies have been conducted to assess its epidemiology in the United States (US).
Methods
Glioblastoma Multiforme (GBM) cases diagnosed between 2000 and 2017 were selected from the SEER research plus program (N = 75047). Age-adjusted annual incidence rates per 100,000 were calculated using the SEER program. To compare GBM rates, non-GBM brain tumor rates were extracted from SEER.
Results
GBM rates have a statistically significant increasing trend over time (β = 0.022, p < 0.01). Conversely, non-GBM rates show a decreasing trend (β=-0.033, p < 0.01). GBM rates were significantly increasing in the Midwest (β = 0.026, p = 0.0033), Northeast (β = 0.037, p < 0.01), South (β = 0.015, p = 0.00080), and West (β = 0.014, p = 0.011). Non-GBM rates were significantly decreasing in the Northeast (β=-0.042, p < 0.01), South (β=-0.038, p < 0.01), and West (β=-0.027, p < 0.01), with a non-significant decrease in the Midwest (β=-0.011, p = 0.062).
Conclusions
The present study confirms a previously reported increase in GBM incidence rates over time, with additional novel findings indicating that this increase may be driven by improved diagnostic accuracy and differentiation from other brain tumors rather than a true rise in GBM cases. These insights can be used to identify specific regions where diagnostic practices have advanced, as well as areas that may be lagging behind.