bluuebunny/crossref_metadata_2025 huggingface dataset:
Ozonated Oil in Liposome Eyedrops Reduces the Formation of Biofilm, Selection of Antibiotic-Resistant Bacteria, and Adhesion of Bacteria to Human Corneal Cells
Authors: Gentili Valentina , Strazzabosco Giovanni , Salgari Niccolò , Mancini Alessandra , Rizzo Sabrina , Beltrami Silvia , Schiuma Giovanna , Casciano Fabio , Alogna Andrea , Passarella Daniela , Davinelli Sergio , Scapagnini Giovanni , Medoro Alessandro , Rizzo Roberta
Published: September 2023

The recent attention to the risk of potential permanent eye damage triggered by ocular infections has been leading to a deeper investigation of the current antimicrobials. An antimicrobial agent used in ophthalmology should possess the following characteristics: a broad antimicrobial spectrum, prompt action even in the presence of organic matter, and nontoxicity. The objective of this study is to compare the antimicrobial efficacy of widely used ophthalmic antiseptics containing povidone-iodine, chlorhexidine, and liposomes containing ozonated sunflower oil. We determined the minimum inhibitory concentration (MIC) on various microbial strains: Staphylococcus aureus (ATCC 6538), methicillin-resistant Staphylococcus aureus (ATCC 33591), Staphylococcus epidermidis (ATCC 12228), Pseudomonas aeruginosa (ATCC 9027), and Escherichia coli (ATCC 873). Furthermore, we assessed its efficacy in controlling antibiotic resistance, biofilm formation, and bacterial adhesion. All three antiseptic ophthalmic preparations showed significant anti-microbicidal and anti-biofilm activity, with the liposomes containing ozonated sunflower oil with the highest ability to control antibiotic resistance and bacteria adhesion to human corneal cells.
Elucidating the Associated Biological Function and Clinical Significance of RHOJ Expression in Urothelial Carcinoma
Authors: Lu Xin-Jie , Lai Hsing-Fan , Wu Sheng-Cheng , Chen Chin-Li , Chiu Yi-Lin
Published: September 2023

Urothelial cancer, a common urinary system malignancy, often presents treatment challenges due to metastasis and chemotherapy side effects. Angiogenesis, crucial for tumor growth, has become a target for drug development. This study explores the expression, prognostic value, and clinical correlation of RHOJ in the TCGA BLCA, GSE31684, and GSE32894 datasets. We identify common differentially expressed genes across these databases and utilize g:Profiler and Cytoscape ClueGO for functional assessment. Further, we perform a gene set enrichment analysis (GSEA) using Hallmark gene sets and use the imsig package for immune cell infiltration analysis. Our analysis indicates that RHOJ expression levels significantly impact survival rates, tumor progression, and immune response in urothelial tumors. High RHOJ expression correlated with poor prognosis, advanced disease stages, and an increase in monocyte population within the tumor microenvironment. This aligns with current literature indicating a key role of immune infiltration in bladder cancer progression and treatment response. Moreover, the GSEA and imsig results further suggest a potential mechanistic link between RHOJ expression and immune-related pathways. Considering the increasing emphasis on immunotherapeutic strategies in bladder cancer management, our findings on RHOJ’s potential as a diagnostic biomarker and its association with immune response open new avenues for therapeutic interventions.
Biodegradable Polyhydroxyalkanoates with a Different Set of Valerate Monomers: Chemical Structure and Physicochemical Properties
Authors: Volova Tatiana G. , Zhila Natalia O. , Kiselev Evgeniy G. , Sukovatyi Aleksey G. , Lukyanenko Anna V. , Shishatskaya Ekaterina I.
Published: September 2023

The properties, features of thermal behavior and crystallization of copolymers containing various types of valerate monomers were studied depending on the set and ratio of monomers. We synthesized and studied the properties of three-component copolymers containing unusual monomers 4-hydroxyvalerate (4HV) and 3-hydroxy-4-methylvalerate (3H4MV), in addition to the usual 3-hydroxybutyrate (3HB) and 3-hydroxyvalerate (3HV) monomers. The results showed that P(3HB-co-3HV-co-4HV) and P(3HB-co-3HV-co-3H4MV) terpolymers tended to increase thermal stability, especially for methylated samples, including an increase in the gap between melting point (Tmelt) and thermal degradation temperature (Tdegr), an increase in the melting point and glass transition temperature, as well as a lower degree of crystallinity (40–46%) compared with P(3HB-co-3HV) (58–66%). The copolymer crystallization kinetics depended on the set and ratio of monomers. For terpolymers during exothermic crystallization, higher rates of spherulite formation (Gmax) were registered, reaching, depending on the ratio of monomers, 1.6–2.0 µm/min, which was several times higher than the Gmax index (0.52 µm/min) for the P(3HB-co-3HV) copolymer. The revealed differences in the thermal properties and crystallization kinetics of terpolymers indicate that they are promising polymers for processing into high quality products from melts.
Resilin Distribution and Abundance in Apis mellifera across Biological Age Classes and Castes
Authors: Anderson Audrey , Keime Noah , Fong Chandler , Kraemer Andrew , Fassbinder-Orth Carol
Published: September 2023

The presence of resilin, an elastomeric protein, in insect vein joints provides the flexible, passive deformations that are crucial to flapping flight. This study investigated the resilin gene expression and autofluorescence dynamics among Apis mellifera (honey bee) worker age classes and drone honey bees. Resilin gene expression was determined via ddPCR on whole honey bees and resilin autofluorescence was measured in the 1m-cu, 2m-cu, Cu-V, and Cu2-V joints on the forewing and the Cu-V joint of the hindwing. Resilin gene expression varied significantly with age, with resilin activity being highest in the pupae. Autofluorescence of the 1m-cu and the Cu-V joints on the ventral forewing and the Cu-V joint on the ventral hindwing varied significantly between age classes on the left and right sides of the wing, with the newly emerged honey bees having the highest level of resilin autofluorescence compared to all other groups. The results of this study suggest that resilin gene expression and deposition on the wing is age-dependent and may inform us more about the physiology of aging in honey bees.
Unraveling the Significance of Draglines: Female Sexual Signalization in the Nursery-Web Spider, Pisaura mirabilis
Authors: Ježová Zuzana , Prokop Pavol , Zvaríková Martina , Zvarík Milan
Published: September 2023

Chemical signals used by animals to attract the opposite sex are well known in insects, but heavily understudied in spiders. We investigated the role of chemical signals in female draglines in a gift-giving spider, Pisaura mirabilis, using combined data from behavioral tests and high-performance liquid chromatography (HPLC). We also investigated whether the quality of sexual signalization is influenced by crucial factors, such as female spider ontogeny, nutritional status, and mating status. We found that draglines of adult (versus subadult) and hungry (versus fed) females stimulated male motivation to produce nuptial gift, and highly sexually excited males invested more silk in gift production than less sexually excited males. Unexpectedly, chemical signals of eggsac-carrying females were similarly sexually attractive to draglines of adult females not carrying eggsac. HPLC identified significant chemical differences in female draglines, but these differences did not always correspond to male behavior. The integration of behavioral and chemical approaches is required to better understand animal behavior in future research.
Impact of Chronic Kidney Disease and Dialysis on Outcome after Surgery for Infective Endocarditis
Authors: Elderia Ahmed , Kiehn Ellen , Djordjevic Ilija , Gerfer Stephen , Eghbalzadeh Kaveh , Gaisendrees Christopher , Deppe Antje-Christin , Kuhn Elmar , Wahlers Thorsten , Weber Carolyn
Published: September 2023

Infective endocarditis (IE) carries a heavy burden of morbidity and mortality in chronic kidney disease (CKD) and hemodialysis (HD) patients. We investigated the risk factors, pathognomonic profile and outcomes of surgically treated IE in CKD and HD patients. We preoperatively identified patients with CKD under hemodialysis (HD group) and compared them with patients without hemodialysis (Non-HD group). Furthermore, we divided the cohort into four groups according to the underlying stage of CKD, with a subsequent outcome analysis. Between 2009 and 2018, 534 Non-HD and 58 HD patients underwent surgery for IE at our institution. The median age was 65.1 [50.6–73.6] and 63.2 [53.4–72.8] years in the Non-HD and HD groups, respectively (p = 0.861). The median EuroSCORE II was 8.0 [5.0–10.0] vs. 9.5 [7.0–12.0] in the Non-HD vs. HD groups (p = 0.004). Patients without CKD had a mortality rate of 5.6% at 30 days and 15.5% at 1 year. Mortality rates proportionally rose with the severity of CKD. Among HD patients, 30-day and 1-year mortality rates were 38.1% and 75.6%, respectively (p < 0.001). Staphylococcus aureus IE was significantly more frequent in the HD group (p = 0.006). In conclusion, outcomes after surgery for IE correlated with the severity of the underlying CKD, with HD patients exhibiting the most unfavorable results. Pre-existing CKD and staphylococcus aureus infection were independent risk factors for 1-year mortality.
Role of Serum Interleukin-6, Interleukin-1β and Interleukin-10 in Assessment of Disease Activity and Nutritional Status in Patients with Inflammatory Bowel Disease
Authors: Godala Małgorzata , Gaszyńska Ewelina , Walczak Konrad , Małecka-Wojciesko Ewa
Published: September 2023

Inflammatory bowel diseases (IBD) are characterised by multifactorial and chronic inflammation. Much attention has been paid to immune dysfunction in inflammatory bowel diseases. The aim of this study was to assess the usefulness of serum IL-6, IL-1β and IL-10 in determining the activity and nutritional status in IBD patients. The case–control study was carried out on 82 patients with IBD; the control group consisted of 25 clinically healthy subjects. The serum concentrations of IL-6, IL-1 β and IL-10 were determined by the quantitative sandwich enzyme-linked immunosorbent assay. There were no significant differences in IL-6 and IL-1β levels in UC and CD patients according to disease activity as assessed by the Montreal classification, Partial Mayo Score and CDAI. Significantly higher IL-6 levels were found in patients with low body fat in comparison to patients with normal body fat. Furthermore, significantly higher mean IL-6 levels were observed in patients with excess body fat in comparison to patients with normal body fat, and also in comparison to patients with deficient body fat. IL-6 and IL-1β may provide extra information regarding the nutritional status of IBD patients. IL-10 can be considered a non-invasive biomarker of IBD activity.
Patient Safety during Propofol Sedation before and after Implementation of Capnography Monitoring
Authors: Baytaş Volkan , Vural Çağıl , Özçelik Menekşe , Torres Rafael Torrejon , Saunders Rhodri , Alkış Neslihan
Published: September 2023

Endoscopic procedures are routinely applied to cancer screening programs and surveillance. The preferred technique is usually deep sedation with propofol being a convenient agent allowing for a quicker patient recovery while maintaining a similar safety profile compared to traditional agents. However, adverse events, including respiratory depression and consequent undesirable cardiovascular side effects, may occur. The goal of this work is to evaluate the patient safety impact of adding capnography during endoscopic procedures under deep propofol sedation. Data were retrospectively collected from patients undergoing deep, procedural sedation for gastrointestinal (GI) endoscopy in October 2019 to January 2021 in a single Turkish university hospital. Included in the analysis were all adult patients classified by the American Society of Anesthesiologists (ASA) as I–IV, who were scheduled for GI endoscopy utilizing propofol alone or in combination. Data on 1840 patients were collected, of whom 1610 (730 pre- and 880 post-capnography implemention) met inclusion criteria. The primary outcome was a change in the composite incidence of mild oxygen desaturation (SpO2 75–90% for <60 s), severe oxygen desaturation (SpO2 < 75% anytime or <90% for >60 s), bradycardia (<60 ppm), and tachycardia (>25% from baseline). Without capnography, on average, 7.5 events of the primary endpoint were observed per 100 procedures and 2.9 with additional capnography monitoring (p < 0.001). A significant reduction was observed for mild oxygen desaturation, with a resulting odds ratio of 0.25 (95% CI 0.14 to 0.46). ASA I patients had the highest difference in combined incidence of any oxygen desaturation of 5.85% in the pre-capnography group and 0.64% in the post-capnography group. Although procedural sedation using propofol is not associated with severe adverse events, the incidence of composite adverse events could be reduced with the addition of capnography monitoring.
Cardiovascular Disease and Stroke in Immune TTP–Challenges and Opportunities
Authors: Sukumar Senthil , Mazepa Marshall A. , Chaturvedi Shruti
Published: September 2023

Advances in the management of immune thrombotic thrombocytopenic purpura (iTTP) have dramatically improved outcomes of acute TTP episodes, and TTP is now treated as a chronic, relapsing disorder. It is now recognized that iTTP survivors are at high risk for vascular disease, with stroke and myocardial infarction occurring at younger ages than in the general population, and cardiovascular disease is the leading cause of premature death in this population. iTTP appears to have a phenotype of accelerated vascular aging with a particular predilection for cerebral circulation, and stroke is much more common than myocardial infarction. In addition to traditional cardiovascular risk factors, low ADAMTS13 activity during clinical remission may be a risk factor for some of these outcomes, such as stroke. Recent studies also suggest that Black patients, who are disproportionately affected by iTTP in the United States, are at higher risk of adverse cardiovascular outcomes, likely due to multifactorial reasons. Additional research is required to establish the risk factors and mechanisms underlying these complications in order to institute optimal screening strategies and identify interventions to improve outcomes.
Magnetic Resonance Volumetric Quantification of Vestibular Endolymphatic Hydrops in Patients with Unilateral Definite Meniere’s Disease Using 3D Inversion Recovery with Real Reconstruction (3D-REAL-IR) Sequence
Authors: Suárez-Vega Víctor , Manrique-Huarte Raquel , Dominguez Pablo , Blanco Melissa , Alonso-Burgos Alberto , Pérez-Fernández Nicolás
Published: September 2023

Background: The 3D-REAL-IR MRI sequence allows for an in vivo visualization of endolymphatic hydrops. Qualitative assessment methods of the severity of vestibular and cochlear hydrops are the most commonly used. Methods: A quantitative volumetric measurement of vestibular EH in patients with definite unilateral Ménière’s disease using the 3D-REAL-IR sequence and the calculation of the endolymphatic ratio (ELR) was intended. Results: Volumetric calculations of the vestibules, vestibular endolymph and vestibular ELR are performed in 96 patients with unilateral Ménière’s disease and correlated with classic qualitative grading scales. Conclusions: Quantitative volumetric measurement of vestibular hydrops using the 3D-REAL-IR sequence is feasible and reproducible in daily clinical practice. Vestibular ELR values exceeding 60% defined radiologically significant vestibular hydrops, while values below 30% defined radiologically non-significant vestibular hydrops.
Indications, Efficacy, Safety, and Clinical Outcomes of 585 nm Pulsed Dye Laser in Non-Malignant Laryngeal Lesions: A Systematic Review
Authors: González-Rodríguez Henar , Mayo-Yáñez Miguel , Maria-Saibene Alberto , Allevi Fabiana , Chiesa-Estomba Carlos M. , Vaira Luigi A. , Lechien Jerome R.
Published: September 2023

The objective of this manuscript was to review the indications, efficacy, and safety of a 585 nm pulsed dye laser (PDL) in non-malignant laryngeal lesions. Following the PRISMA statement recommendations, three independent authors searched for articles published in PubMed/MEDLINE, the Cochrane Library, Google Scholar, Scielo, and Web of Science. A bias analysis was performed following NICE guidance tools. From the 506 identified publications, 19 observational studies met the inclusion criteria. The PDL improves vocal quality objectively and subjectively in vascular lesions (p < 0.005) and improves vocal quality in patients with dysplasia/leukoplasia without changing the natural history of the disease compared to other treatments. Reinke’s edema and granulomas require an average of 1.5 PDL sessions for resolution. Treatment of recurrent respiratory papillomatosis requires multiple sessions, with complete remission achieved in 50–70% of patients. Regardless of the lesion, the tolerance of the procedure under local anesthesia is exceptional (84–97%), and the results in terms of regression and vocal quality are promising. The complication rate is minimal, and the procedure does not interfere with other treatment alternatives. There is no consensus on laser settings. The lack of consistent use in evaluating vocal outcomes, whether objective or subjective, prevents the comparability between studies. The 585 nm pulsed dye laser appears to be an effective and safe therapeutic option in patients with non-malignant laryngeal pathology. Future controlled studies are needed to compare the 585 nm pulsed dye laser with other lasers or cold instrument procedures.
How Digital Financial Inclusion Boosts Tourism: Evidence from Chinese Cities
Authors: Zhang Chi , Liu Yayu , Pu Zhengning
Published: September 2023

It is crucial to explore the impact of digital financial inclusion on tourism for national economic development. This paper utilizes panel data from 256 prefecture-level cities in China between 2011 and 2019 to examine the influence of digital financial inclusion on tourism. The findings demonstrate that digital financial inclusion significantly contributes to the development of the tourism industry. Notably, its coverage breadth, depth of use, and level of digitalization also have positive effects. Mechanism analysis reveals that digital financial inclusion facilitates the growth of tourism by supporting the development of tourism enterprises and enhancing consumer spending. Heterogeneity analysis further reveals regional and urban disparities in the promotion of digital financial inclusion, with the effect being more pronounced in the eastern region and larger cities. In comparison to existing studies, this paper delves into the mechanisms through which digital financial inclusion impacts tourism, as well as investigates regional and city size discrepancies. Consequently, governments should strive to foster the development of digital financial inclusion to attract market players and promote the advancement of residents’ consumption, thereby bolstering tourism development.
Using Diachronic Cartography and GIS to Map Forest Landscape Changes in the Putna-Vrancea Natural Park, Romania
Authors: Istrate George-Adrian , Istrate Vasilică , Ursu Adrian , Ichim Pavel , Breabăn Iuliana-Gabriela
Published: September 2023

The Putna-Vrancea Natural Park (PVNP) is one of the wildest mountain areas in Romania and is home to internationally important species of flora and fauna. Although the park’s area is covered by forests, the last two centuries have seen several major transformations. The aim of this article is to present a historical approach to the development of habitat areas within the PVNP, with an attempt to show both the situation before and after the establishment of its protection regime. The changes in the forest area were identified using available cartographic material from 1789, 1895, 1957, 1975, 2005, and 2018. The analysis of forest distribution according to different classes of natural factors (altitude, slope, soil type, and lithology) highlighted the early 20th century when forest cover decreased at low altitudes and slopes. However, anthropogenic factors were responsible for almost all changes. The specific socio-economic system of the Vrancea Mountains, according to which the forest was and still is owned by the inhabitants of several villages, led to periods of deforestation: burning to increase the area of pastures and the unsustainable exploitation of wood by some companies that had been granted this right by the owners. In the 1960s and 1970s, the mountain pastures were reforested, and in the last 20 years, the mountain pastures have been transformed into forests. Although the use of old maps for this type of analysis has certain limitations, the results obtained provide insight into the causes of the transformation of forest landscapes in some areas of the PVNP.
The Development of an Experimental Framework to Explore the Generative Design Preference of a Machine Learning-Assisted Residential Site Plan Layout
Authors: Sun Pei , Yan Fengying , He Qiwei , Liu Hongjiang
Published: September 2023

Generative design based on machine learning has become an important area of application for artificial intelligence. Regarding the generative design process for residential site plan layouts (hereafter referred to as “RSPLs”), the lack of experimental demonstration begs the question: what are the design preferences of machine learning? In this case, all design elements of the target object need to be extracted as much as possible to conduct experimental studies to produce scientific experimental results. Based on this, the Pix2pix model was used as the test case for Chinese residential areas in this study. An experimental framework of “extract-translate-machine-learning-evaluate” is proposed, combining different machine and manual computations, as well as quantitative and qualitative evaluation techniques, to jointly determine which design elements and their characteristic representations are machine learning design preferences in the field of RSPL. The results show that machine learning can assist in optimizing the design of two particular RSPL elements to conform to residential site layout plans: plaza paving and landscaped green space. In addition, two other major elements, public facilities and spatial structures, were also found to exhibit more significant design preferences, with the largest percentage increase in the number of changes required after machine learning. Finally, the experimental framework established in this study compensates for the lack of consideration that all design elements of a residential area simultaneously utilize the same methodological framework. This can also assist planners in developing solutions that better meet the expectations of residents and can clarify the potential and advantageous directions for the application of machine learning-assisted RSPL.
Historical Data for Natural Hazard Risk Mitigation and Land Use Planning
Authors: Luino Fabio , Barriendos Mariano , Gizzi Fabrizio Terenzio , Glaser Ruediger , Gruetzner Christoph , Palmieri Walter , Porfido Sabina , Sangster Heather , Turconi Laura
Published: September 2023

This paper demonstrates how historical research is a valuable tool for identifying past geological, geomorphological and climatic hazards and therefore critical for mitigating and reducing future risk. The authors describe the potential of a scientific field that straddles that of the geologist, geographer, historian and archivist. Historical records include a range of materials and sources of information, which can be very diverse; from written documents to cartographies, and from drawings to marble tombstones. They are all useful and convey important data, on the date of the event, the size of the phenomena, sometimes on ground effects, damage or magnitude. The authors discuss how to conduct historical research by providing a list of locations and how important historical documents can be found. Works that mention geological phenomena are listed, starting with the first occasional descriptions by individuals in letters, up to very specific publications in individual fields of interest. With this introduction, the editors of the Special Issue wish to draw attention to the importance of historical documentation, which is too often ignored or considered of low priority by the scientific community, but can contain key information on events, their impacts and social and cultural adaptations.
Management Implications at a Protected, Peri-Urban, Salt Lake Ecosystem: The Case of Larnaca’s Salt Lakes (Cyprus)
Authors: Bekri Eleni S. , Kokkoris Ioannis P. , Christodoulou Charalambos S. , Sophocleous-Lemonari Antonia , Dimopoulos Panayotis
Published: September 2023

Larnaca’s salt lakes constitute one of the most important protected areas in Cyprus and in the southeast Mediterranean. It is in continuity with the urban area of Larnaca city, being the major green infrastructure in the area, supporting (among others) biodiversity, recreation, culture, and food production. The present study aims to provide an overview of the area’s ecosystem types and their potential to provide ecosystem services, focusing on assessing the water ecosystem condition and drafting the relevant baseline accounts. The results of the study include an ecosystem type map of the area, followed by potential supply maps of ecosystem services, for the three major categories (i.e., provisioning, regulating and maintenance, and cultural) and the estimation and assessment of ecosystem condition variables for wetlands, as proposed by the EU-wide methodology to map and assess the ecosystem condition, in line with the System of Environmental Economic Accounting—Ecosystem Accounting (SEEA EA). A critical exceedance (over 10%) of the imperviousness and the increase in the soil moisture deficit within the wider salt lakes area have been identified and can constitute useful variables associated with the anthropogenic, climatic, and other effects on the condition of the salt lakes. Discussion for integrating this information to existing knowledge is provided toward supporting scientifically informed decision and policymaking for the sustainable development of protected areas.
Exploring Small-Diameter Melanomas: A Retrospective Study on Clinical and Dermoscopic Features
Authors: Hunziker Maria Fernanda Vianna , Abdalla Beatrice Martinez Zugaib , Brandão Flavia Vieira , Meneghello Luana Pizarro , Hunnicutt Jaciara Moreira Sodré , Di Giacomo Thais Helena Bello , Abdalla Cristina Martinez Zugaib , Sortino Ana Maria Fagundes
Published: September 2023

Background: Early melanoma detection allows for timely intervention and treatment, significantly improving the chances of favorable outcomes for patients. Small-diameter melanoma (SDM) typically represents an initial growth phase of cutaneous melanoma. One of the challenges in detecting melanoma in their early stage lies in the fact that dermoscopy criteria have been primarily designed for fully developed lesions. Early-stage melanomas may be difficult to detect and possibly even be overlooked or misinterpreted during examinations. Methods: The primary aim of this study was to identify valuable clinical and dermoscopic clues to enhance the detection of SDMs. To achieve this objective, we conducted a comprehensive retrospective analysis, including forty SDMs with a diameter of 5 mm or less. These cases were diagnosed over an 8-year period and were collected from five referral centers across Brazil. Seven experienced dermatologists independently assessed the dermoscopic features of each lesion. Additionally, this study includes demographic and histological information. Results: The study encompassed a total of 28 patients, of which 16 were females, accounting for 58% of the participants, with an average age of 43.6 years. Among the small-diameter melanomas (SDMs) under investigation, the majority, constituting 27 cases (69.2%), were identified as “de novo” lesions, i.e., not associated with a nevus. Additionally, eight SDMs (20%) exhibited invasive characteristics, with Breslow index measurements ranging between 0.2 to 0.4 mm, suggesting an early stage of malignancy. During dermoscopic examinations, the most prevalent features observed were irregular dots and globules, present in 95% and 87.5% of cases, respectively. Moreover, brown structureless areas were identified in 70% of lesions, followed by atypical network (67.5%), pseudopods (55%), dotted vessels (47.5%), flat structureless blue-gray areas (42.5%), and irregular blotches (40%). Notably, all SDM were diagnosed in patients under surveillance through total body skin photography (TBSP) and Digital Dermoscopy (DD). Conclusions: Dermoscopy significantly enhances the diagnostic accuracy of melanoma, even in its early stages. Particularly for high-risk patients with numerous nevi, the identification of a new lesion or subtle changes on dermoscopy during follow-up may serve as the sole clue for an early diagnosis. This emphasizes the critical role of dermoscopy in SDM detection and reinforces the importance of surveillance in high-risk patients for timely and effective management.
[6-(Furan-2-yl)-2,2′-bipyridine]bis(triphenylphosphine) Copper(I) Tetrafluoroborate
Authors: Kouvatsis Panagiotis , Glykos Dimitrios , Plakatouras John C. , Malandrinos Gerasimos
Published: September 2023

A new heteroleptic Cu(I) complex, [Cu(L)(PPh3)2][BF4] (L = 6-(furan-2-yl)-2,2′-bipyridine; PPh3 = triphenylphosphine), was successfully synthesized and characterized. Its molecular structure was determined using X-ray crystallography, and NMR as well as HR-ESI-MS data confirm the compound’s integrity in solution. The complex exhibits emission solely in the solid state (λem = 576 nm) and demonstrates a photoluminescence quantum yield of 2.5%.
Texture-Induced Corrosion Resistance of Dissimilar AA7204/AA6082 Friction Stir Welded Joints
Authors: Guan Liqun , Yuan Manfa , Zhang Jin , Deng Yunlai , Xu Xuehong , Wan Li
Published: September 2023

The quasi in situ EBSD test was applied to study the effect of grain orientation on corrosion behaviors of the thermomechanically affected zone I (TMAZ I) of dissimilar AA6082/AA7204 friction stir welding (FSW) joints in this work. The results show that the structure with grain orientation close to the brass texture ({110}<112>) has excellent corrosion resistance, which contributes to the better corrosion performance of the TMAZ I of the 7204-AS joint than the 7204-RS joint. Furthermore, the brass texture around by S texture ({213}<364>) in the TMAZ I of the 7204-AS joint is slightly corroded, and the orientation of the remaining structure is closer to the ({110}<112>) than before, which indicates that the corrosion, like deformation, is carried out alongside the {110} plane for the structure with grain orientation near {110}<112>. Those findings could provide new insight into the designed FSW joints and improve the corrosion resistance of the wrought aluminum alloy.
Hot Deformation Behavior of Hastelloy C276 Alloy: Microstructural Variation and Constitutive Models
Authors: He Daoguang , Chen Shibing , Lin Yongcheng , Yan Xintao , Liu Guan
Published: September 2023

Isothermal deformation experiments of the Hastelloy C276 alloy were executed using the Gleeble-3500 hot simulator at a temperature range of 1000–1150 °C and a strain rate range of 0.01–10 s−1. Microstructural evolution mechanisms were analyzed via transmission electron microscope (TEM) and electron backscatter diffraction (EBSD). Results reveal that the influences of hot compression parameters on the microstructure variation features and flow behaviors of the Hastelloy C276 alloy were significant. The intense strain hardening (SH) effects caused by the accumulation of substructures were promoted when the strain rates were increased, and true stresses exhibited a notable increasing tendency. However, the apparent DRV effects caused by the annihilation of substructures and the increasingly dynamic recrystallization (DRX) behaviors occurred at high compressed temperature, inducing the reduction in true stresses. In addition, a physical-based (PB) constitutive model and a long short-term memory (LSTM) model optimized using the particle swarm optimization (PSO) algorithm were established to predict the flow behavior of Hastelloy C276 alloy. The smaller average absolute relative error and greater relation coefficient suggest that the LSTM model possesses a higher forecasting accuracy than the PB model.
The Influence of Special Environments on SiC MOSFETs
Authors: Li Zhigang , Jiang Jie , He Zhiyuan , Hu Shengdong , Shi Yijun , Zhao Zhenbo , He Yigang , Chen Yiqiang , Lu Guoguang
Published: September 2023

In this work, the influences of special environments (hydrogen gas and high temperature, high humidity environments) on the performance of three types of SiC MOSFETs are investigated. The results reveal several noteworthy observations. Firstly, after 500 h in a hydrogen gas environment, all the SiC MOSFETs exhibited a negative drift in threshold voltage, accompanied by an increase in maximum transconductance and drain current (@ VGS/VDS = 13 V/3 V). This phenomenon can be attributed to that the hydrogen atoms can increase the positive fixed charges in the oxide and increase the electron mobility in the channel. In addition, high temperature did not intensify the impact of hydrogen on the devices and electron mobility. Instead, prolonged exposure to high temperatures may induce stress on the SiO2/SiC interface, leading to a decrease in electron mobility, subsequently reducing the transconductance and drain current (@ VGS/VDS = 13 V/3 V). The high temperature, high humidity environment can cause a certain negative drift in the devices’ threshold voltage. With the increasing duration of the experiment, the maximum transconductance and drain current (@ VGS/VDS = 18V (20 V)/3 V) gradually decreased. This may be because the presence of moisture can lead to corrosion of the devices’ metal contacts and interconnects, which can increase the devices’ resistance and lead to a decrease in the devices’ maximum transconductance and drain current.
Rosen-Type Piezoelectric Transformers Based on 0.5Ba(Zr0.2Ti0.8)O3–0.5(Ba0.7Ca0.3)TiO3 Ceramic and Doped with Sb2O3
Authors: Jung Suk-Young , Lee Gwangseop , Kim Tae-wan , Kim Sung-Jin , Koh Jung-Hyuk
Published: September 2023

In this study, the characteristics in the lead-free piezoelectric ceramic 0.5Ba(Zr0.2Ti0.8)O3−0.5(Ba0.7Ca0.3)TiO3 (0.5BZT–0.5BCT) were investigated to assess its potential for Rosen-type piezoelectric transformers. This piezoelectric ceramic has a piezoelectric charge coefficient d33 of 430 pC/N, an electromechanical coupling factor kp of 49%, a dielectric constant εr of 2836, a remnant polarization Pr of 4.98 μC/cm2, and a coercive electric field Ec of 2.41 kV/cm. Sb2O3 was soft doped with 0.05, 0.1, 0.15, and 0.2 mol%, respectively, and exhibited excellent physical properties at 0.1 mol%. Based on this, a piezoelectric transformer was fabricated and measured, and it showed better output characteristics than pure 0.5BZT–0.5BCT. The amplification ratio (Vout/Vin) was optimized based on the device geometry and properties of the piezoelectric material. Moreover, the output characteristics of the Rosen−type piezoelectric transformer were simulated with the PSpice program. Output values of the fabricated and simulated piezoelectric transformers for the r vibrational frequency were compared and analyzed. Accordingly, the step-up amplification ratios Vout/Vin of the fabricated and simulated devices at the vibrational frequency were compared as well. This piezoelectric transformer could replace silicon steel transformers and be used for the creation of black light and for laptop chargers.
Package Design Thermal Optimization for Metal-Oxide Gas Sensors by Finite Element Modeling and Infra-Red Imaging Characterization
Authors: Stoukatch Serguei , Dupont Francois , Laurent Philippe , Redouté Jean-Michel
Published: September 2023

We designed a 3D geometrical model of a metal-oxide gas sensor and its custom packaging and used it in finite element modeling (FEM) analysis for obtaining temperature and heat flux distribution. The 3D computer simulation, performed with GetDP software (version 3.5.0, 13 May 2022), accurately predicted the temperature distribution variation across the entire assembly. Knowing the temperature variation and the location of the hot spots allowed us to select the best electrical interconnect method and to choose the optimal materials combination and optimal geometry. The thermal modeling also confirmed the need to use a low thermal conductivity material to insulate the MOX sensor since the latter is heated to its operational temperature of 250 °C. For that purpose, we used the in-house formulated xerogel–epoxy composite of thermal conductivity of 0.108 W m−1 K−1, which is at least 30% less compared to the best-in-class among commercially available materials. Based on the 3D FEM outputs, we designed, assembled, and characterized a fully functional packaged MOX gas sensor in several configurations. We measured the temperature distribution on all parts of the MOX gas sensor assembly using a thermal imaging infrared (IR) microscope. The results of 3D FEM are in good agreement with the temperature distribution obtained by the non-contact IR thermal characterization.
Raw Material Supply for Lithium-Ion Batteries in the Circular Economy
Authors: Chagnes Alexandre , Forsberg Kerstin
Published: September 2023

The energy transition relies on the development of technologies that make it possible to produce energy in a sustainable manner from resources such as wind, sun, potential energy, etc [...]
An Analysis of the Mapping Relationship between Microstructure and Solidification Parameters during Aluminum Fused Coating
Authors: Zhao Guangxi , Zhang Jialei , Yang Xianhai
Published: September 2023

Metal fused-coating technology has the advantages of both low cost and high efficiency and is a new additive manufacturing technology in recent years. The previous studies were mainly aimed at the optimization of process parameters and the control of the surface quality of parts, while there were few theoretical analyses on the microstructure morphology after solidification. A three-dimensional transient numerical model was established to calculate temperature gradient and solidification rate, considering the changes in material physical properties with temperature during the calculation process. The temperature gradient on the substrate surface is jointly affected by the melt flowing out of the nozzle and the welding arc. It was found that the solidification front of the aluminum alloy was in an unstable state during the coating process. When the value of G/R decreases, the microstructure of the solidification interface gradually changes from columnar crystals to columnar dendrites and equiaxial crystals. The microstructure at the bottom of both the molten pool and coating layer is columnar crystal, while the microstructure at the upper part is equiaxed crystal.
Sex Modifies the Impact of Type 2 Diabetes Mellitus on the Murine Whole Brain Metabolome
Authors: Norman Jennifer E. , Nuthikattu Saivageethi , Milenkovic Dragan , Villablanca Amparo C.
Published: September 2023

Type 2 diabetes mellitus (T2DM) leads to the development of cardiovascular diseases, cognitive impairment, and dementia. There are sex differences in the presentation of T2DM and its associated complications. We sought to determine the impact of sex and T2DM on the brain metabolome to gain insights into the underlying mechanisms of T2DM-associated cognitive complications. Untargeted metabolomic analysis was performed, using liquid chromatography-mass spectrometry, on whole brain tissue from adult male and female db/db mice (a T2DM model) compared to wild-type (WT) C57Bl6/J mice. Regardless of sex, T2DM increased free fatty acids and decreased acylcarnitines in the brain. Sex impacted the number (103 versus 65 in males and females, respectively), and types of metabolites shifted by T2DM. Many choline-containing phospholipids were decreased by T2DM in males. Female-specific T2DM effects included changes in neuromodulatory metabolites (γ-aminobutyric acid, 2-linoleoyl glycerol, N-methylaspartic acid, and taurine). Further, there were more significantly different metabolites between sexes in the T2DM condition as compared to the WT controls (54 vs. 15 in T2DM and WT, respectively). T2DM alters the murine brain metabolome in both sex-independent and sex-dependent manners. This work extends our understanding of brain metabolic sex differences in T2DM, cognitive implications, and potential sex-specific metabolic therapeutic targets.
Numerical and Experimental Analysis of Dual-Beam Laser Polishing Additive Manufacturing Ti6Al4V
Authors: Zeng Junyong , Zhang Wei , Guo Ting , Lou Yan , Wang Wenqi , Zhao Zhenyu , Wang Chao
Published: September 2023

Laser polishing is an emerging efficient technique to remove surface asperity without polluting the environment. However, the insufficient understanding of the mechanism of laser polishing has limited its practical application in industry. In this study, a dual-beam laser polishing experiment was carried out to reduce the roughness of a primary Ti6Al4V sample, and the polishing mechanism was well studied using simulation analysis. The results showed that the surface roughness of the sample was efficiently reduced from an initial 10.96 μm to 1.421 μm using dual-beam laser processing. The simulation analysis regarding the evolution of material surface morphology and the flow behavior of the molten pool during laser the polishing process revealed that the capillary force attributed to surface tension was the main driving force for flattening the large curvature surface of the molten pool at the initial stage, whereas the thermocapillary force influenced from temperature gradient played the key role of eliminating the secondary roughness at the edge of the molten pool during the continuous wave laser polishing process. However, the effect of thermocapillary force can be ignored during the second processing stage in dual-beam laser polishing. The simulation result is well in agreement with the experimental result, indicating the accuracy of the mechanism for the dual-beam laser polishing process. In summary, this work reveals the effect of capillary force and thermocapillary force on molten pool flows during the dual-beam laser polishing processes. Moreover, it is also proved that the dual-beam laser polishing process can further reduce the surface roughness of a sample and obtain a smoother surface.
Origin of Quartz Diorite and Mafic Enclaves in the Delong Gold-Copper Deposit and Evaluation of the Gold-Copper Mineralization Potential
Authors: Chen Jiajie , Fu Lebing , Leng Chengbiao , Zhao Xu , Ma Jian , Gao Hongze , Xia Yu
Published: September 2023

The Triassic Paleo-Tethyan magmatic belt in the East Kunlun Orogen (EKO) hosts a small number of porphyry-skarn deposits. The controls of these deposits, especially those in the eastern EKO, are poorly understood. In this contribution, we report new petrological, zircon U-Th-Pb-Hf isotopic, whole-rock elemental with Sr-Nd isotopic, and mineral chemistry data of the Delong quartz diorite and mafic enclaves to constrain their petrogenesis and metal fertility. The quartz diorite and mafic enclaves are emplaced in the Late Triassic (ca. 234 Ma). They are medium-K, metaluminous, enriched in large-ion lithophile elements (e.g., Rb, Ba, Th) and light rare earth elements (e.g., La, Ce, Nd), and relatively depleted in high field strength elements (e.g., Nb, Ta, Ti, P) and heavy rare earth elements (e.g., Gd, Er, Tm, Yb). The quartz diorite show similar (87Sr/86Sr)i (0.712584~0.713172) and more depleted εNd(t) (−6.4~−5.7) and εHf(t) (−2.3~+2.6) to those of mafic enclaves ((87Sr/86Sr)i = 0.712463~0.713093; εNd(t) = −6.4~−6.0; εHf(t) = −9.4~−4.8). Geochemical compositions of zircon, amphibole, and biotite yield high water content (5.3 wt.%~6.9 wt.% and 6.1 wt.%~7.3 wt.% based on amphibole, respectively) and high redox state for both the quartz diorite and mafic enclaves. These data, together with petrography, indicate the Delong intrusion was formed by mingling of magmas from enriched mantle and lower continental crust with juvenile materials. The oxidized and water-rich features of these magmas denote they have potential for porphyry Cu (±Au ± Mo) deposits, as do some Triassic magmatic rocks in the eastern EKO that show similar geochemical and petrographic characteristics with the Delong intrusion.
Origin of Himalayan Eocene Adakitic Rocks and Leucogranites: Constraints from Geochemistry, U-Pb Geochronology and Sr-Nd-Pb-Hf Isotopes
Authors: Liu Hang , Li Wenchang , Cao Huawen , Zhang Xiangfei , Li Yang , Gao Ke , Dong Lei , Zhang Kai , Liu Xin
Published: September 2023

Within the Himalayan collisional belt, granites occur along two subparallel belts, namely, the Tethyan Himalayan Sequence (THS) and the Greater Himalayan Crystalline Complex (GHC). In this study, Eocene adakitic rocks and leucogranite are found only in the northern Himalayas, so further research is required to constrain their origin. Here, we present zircon U–Pb and monazite U–Th–Pb ages, Sr–Nd–Pb and Hf isotopes, and whole-rock major and trace elements for Liemai muscovite granite in the eastern Himalayan region. The U–(Th)–Pb results show that Liemai muscovite granite was emplaced at 43 Ma, and that its geochemical characteristics are similar to those of adakitic rocks of the same age (Dala, Quedang, Ridang, etc.). Combined with previous studies, both Eocene adakitic rocks and leucogranite are high-potassium calc-alkaline peraluminous granites. The former is relatively rich in large-ion lithophile elements (LILEs), such as Ba and Sr, and relatively deficient in high-field-strength elements (HFSEs), such as Nb, Ta, Zr, and Y, with weak or no Eu anomalies, and the average light rare earth element (LREE)/heavy rare earth element (HREE) ratio is 17.8. The latter is enriched in LILEs (such as Rb) and U, Ta, and Pb, and depleted in HFSEs (such as Nb and Zr), La, and Nd, with obvious negative Sr, Ba, and Eu anomalies and a mean LREE/HREE ratio of 10.7. The 87Sr/86Sr of the former is in the range of 0.707517–0.725100, εNd (t) ranged from −1.2 to −14.7, the average is −11.6, εHf (t) ranged from −0.5 to −65, the average is −12.2. The average values of (206Pb/204Pb) i, (207Pb/204Pb) i and (208Pb/204Pb) i are 18.788, 15.712 and 39.221, respectively; The 87Sr/86Sr of the latter is in the range of 0.711049~0.720429, εNd (t) ranged from −9.8 to −13.8, the average is −12.3, εHf (t) ranged from −4.2 to −10, the average is −6.7. The isotopic characteristics indicate that adakitic rocks and leucogranites are derived from the ancient lower crust, and both may be derived from metamorphic rocks of the GHC. In this paper, the origin of the two is associated with the transformation of the Himalayan tectonic system during the Eocene, and it is inferred that the deep crust may have altered the tectonic environment (temperature and pressure), resulting in an obvious episodic growth trend of leucogranite and significant development of adakitic rocks from 51 to 40 Ma. From 40 to 35 Ma, the development of Eocene magmatic rocks was hindered, and adakitic rocks disappeared. It is proposed that the genetic difference is related to the transition from high to low angles of the subducting plate in the crustal thickening process.