bluuebunny/crossref_metadata_2025 huggingface dataset:
Gostinski lokali in prehranjevanje zunaj doma v Mariboru
Authors: Drozg Vlado
Published: January 2025

Besedilo obravnava prehranjevanje zunaj doma in s tem povezane gostinske lokale v Mariboru. Prehranjevanje zunaj doma je v gospodarsko razvitih družbah vse bolj povezano s preživljanjem prostega časa, zabavo in druženjem. Značilnosti gostinskih lokalov v Mariboru – vrste lokalov, razmestitev po območju mesta, spremembe v številu in strukturi v preteklih 20 letih, so prikazane v kontekstu družbenih razmer in prehranjevalnih navad anketirancev. Podatke o strukturi gostinskih lokalov in prehranjevalnih navadah smo pridobili z opazovanjem ter nestrukturiranimi razgovori z zaposlenimi in naključno izbranimi gosti. Povečalo se je število gostinskih lokalov in spremenila se je njih struktura - več je lokalov s hitro hrano in lokalov s tujo kuhinjo.
Developing a procedure for secondary data analysis on foreign attitudes toward Russia: a case of Japan
Authors: Shapovalova Maria
Published: January 2025

The attention of readers is drawn to a presentation of the principles of collecting and analyzing secondary data on the attitude towards Russia of public opinion in foreign countries, based on a generalization of the experience of similar studies. Each principle cited is illustrated by the example of a study of the attitude towards Russia of the Japanese.
It is assumed that the methodology of secondary analysis should provide information that meets the following requirements: a) reliable and valid; b) with as unambiguous and clear interpretation as possible; c) having predictive value. To ensure this, it is necessary to take into account that 1) a meaningful interpretation of the dynamics of public opinion requires taking into account its historical state and, accordingly, a long analyzed period; 2) "attitude towards Russia" or any other country is a complex, heterogeneous and multidimensional latent variable, therefore, for secondary analysis, it is desirable to include as many empirical indicators as possible that have appeared in various mass surveys; 3) at the same time, the "attitude towards Russia" should be considered as a single variable, which is impossible without the reduction of a multitude of indicators, which is ensured, at least, by their homogeneity.
The proposed conditions, applied to representative mass surveys, face the fact that their data usually have rigid restrictions both in the number of indicators and in the time coverage, which gives rise to the inevitable fragmentation of the data. Therefore, the collected information can, as a rule, be reduced primarily to some generalized "qualitative" assessments of the situation. These can then be formally combined into indices (for example, an index of favorability) for generalization and interpretation. At the level of indices, there are opportunities for partial and conditional filling of gaps in fragmented data.
The application of the described principles and techniques to the public opinion of Japan made it possible to conclude that at the present time, the attitudes towards Russia in the public opinion of Japan are experiencing the deepest crisis in the entire post-Soviet history, and there are all the grounds to call the sentiments of Japanese public opinion clearly anti-Russian. Obtaining this conclusion did not require independent collection of empirical data, all the necessary survey results were already available in the public domain, their volume and quality allowed for an analysis that seems quite reliable and valid.
Social as a category/ Transl. by N. V. Ivashchenkova
Authors: Dewey John
Published: January 2025

The translation of the article Dewey J. Social as a category, The Monist, 1928, vol. 38, no. 2. P. 161-177.
Development of a Daycare Center Service Model for the Elderly through Community Participation: An Action Research Approach
Authors: Pilayon Benjayamas , Chueaduangpui Kanin , Saentho Juthaluck , Kongmant Ruchakron , Turnbull Niruwan
Published: January 2025

Introduction: This study aimed to develop a service model for daycare centers for the elderly through community participation using participatory action research methods. The objectives were threefold: (1) to investigate the current situation of the elderly in the community and their needs for daycare center services, (2) to develop a daycare center for the elderly with active community involvement, and (3) to evaluate the effectiveness of the service delivery at the daycare center for the elderly. Methods: The study was conducted in Ban Kho Sub district, Phon Sawan District, Nakhon Phanom Province. Research participants included 210 elderly individuals surveyed to assess their situation, and 15 key informants, including elderly club leaders, sub district health promotion hospital staff, volunteers, sub district administrative organization officers, and village health volunteers, were specifically selected for in-depth insights. The research process was structured into three phases: Phase 1 focused on studying the situation of the elderly in the community and their service needs; Phase 2 was dedicated to developing the daycare center with community participation; and Phase 3 involved evaluating the service delivery of the daycare center. Results: The results indicated that the development process of the daycare center service model for the elderly, through community participation, involved four key mechanisms: elderly clubs, sub district health promotion hospitals, volunteer teachers or technicians, and village volunteers. Additionally, the supporting mechanisms included academic institutions, hospitals, temples, village heads, the Non-Formal Education Center, foundations, and the sub district administrative organization. The comprehensive service model encompassed five components: health, social, psychological, economic, and environmental aspects. Conclusion: The study successfully developed a daycare center service model for the elderly through community participation, which can be expanded and adapted to other semi-urban and semi-rural contexts. This model demonstrates the importance of community involvement in providing holistic care for the elderly, addressing various aspects of their well-being.
Intelligent Cloud Systems: AI-Driven Enhancements in Scalability and Predictive Resource Management
Authors: Banerjee Somnath
Published: January 2025

his research article explores the transformative role of Artificial Intelligence (AI) in cloud computing, with a focus on its influence on scalability, resource management, and predictive analytics within distributed systems. As cloud infrastructure becomes integral to organizational operations, AI technologies have emerged as vital tools for enhancing performance and efficiency. The study emphasizes how AI enables scalability through dynamic resource allocation and auto-scaling, allowing systems to adapt seamlessly to changing demands. It also examines AI-driven resource management strategies, which utilize machine learning algorithms to optimize operations, lower costs, and ensure system resilience through predictive maintenance and anomaly detection. Furthermore, the article highlights predictive analytics, demonstrating how AI processes large datasets to support informed decision making and improve system reliability. By integrating intelligent automation with cloud computing, this article underscores AI's pivotal role in advancing the capabilities of distributed systems.
Application of Elastomer Microsphere Particles as Water-Based Drilling Fluid Lost Circulation Material
Authors: Yang Lili , Ou Zhiting , Chang Xiangyang , Wu Jiale , Chen Haozhe , Jiang Guancheng , Ma Jiaying , Dong Tengfei , Wu Yunpeng , Yu Changjiang , Feng Shangjiang
Published: January 2025

Lost circulation is a common issue during oil and gas well drilling, presenting significant safety hazards and resulting in substantial economic losses. Bridging materials typically exhibit limited deformation and poor adaptability to formation pores and fractures, primarily due to size mismatching. Polymer gel materials have the potential to address these issues effectively. While strength is a crucial factor affecting plugging performance, other properties—such as the toughness and elasticity of polymer gel particles—are often overlooked. In this research, we introduce a novel elastomer plugging material that exhibits high toughness and elasticity. The material is composed of polyampholytes, which are synthesized through the copolymerization of an acrylate monomer with long alkyl side groups and a pair of oppositely charged monomers. The acrylic monomer enhances the mobility of the polymer chain, while the oppositely charged monomer generates a gradient interaction, resulting in the formation of ionic aggregates with a broad range of sizes and stiffness. The multigradient strong interaction affords the elastomer remarkable strength and elasticity, which, in turn, safeguards the structural integrity of microsphere particles when subjected to elevated pressure and shear stress. Additionally, the presence of weak interactions, enabled by high mobility, promotes gradual energy dissipation, ultimately enhancing the toughness of the material. PABD [poly (AMPS-BXSZ-DMDAAC)] microsphere particles possess the ability to effectively plug leakage channels by infiltrating pore cracks that are smaller than their own size. Additionally, they can form an elastomer block layer to seal cracks that are larger than their own size, which is facilitated by self-healing through the accumulation of particles and the intermolecular forces between them. As the pressure increases, the plugging layer compresses and becomes more dense, thereby effectively preventing the leakage of drilling fluid into the formation. The experimental results demonstrate that PABD microsphere particles effectively obstruct 8-darcy and 180-darcy consolidated sand trays at temperatures as high as 150°C. Moreover, these particles can be used to seal unconsolidated sand beds of 40−60 mesh, and their plugging performance is significantly enhanced when combined with traditional rubber. This study emphasizes the considerable application potential of elastomer materials in drilling operations.
Lung tumoroids as a testing platform for precision CAR T-cell therapy
Authors: Schmueck-Henneresse Michael , Ehlen Lukas , Farrera-Sal Martí , Szyska Martin , Arndt Janine , Schallenberg Simon , Scholz Cedric , Yang Mingxing , Vollbrecht Claudia , Löwa Anna , Friedrich Rebecca , Mai Marco , Peter Lena , Picht Samira , Schulenberg Sarah , Geray Daniel , Korus Gabriela , Sommerfeld Anke , Treue Denise , Strauchmann Julia , Elsner Aron , Kath Jonas , Vallone Valeria Fernandez , Joosten Maria , Klatte-Schulz Franka , Petersen Ansgar , Stachelscheid Harald , Wagner Dimitrios , Spies Claudia , Rückert Jens-Carsten , Hocke Andreas , Polansky Julia , Stark Regina , Klein Oliver
Published: January 2025

Lung cancer, the leading cause of cancer-related mortality, presents major challenges for both standard-of-care therapies and innovative treatments like CAR T cells due to tumor heterogeneity and resistance. To aid in personalized treatment decisions, preclinical models that incorporate these patient-specific factors are essential. In this study, we developed a platform using matched lung tumoroids and healthy lung organoids. The tumoroids retained the identity of the original tumors, as confirmed by genomic, epigenomic, histological, and proteomic analyses. These tumoroids accurately replicated individual patient responses to standard-of-care therapies, highlighting their predictive value. Our platform enabled the identification of individual responses to CAR T cells and associated mechanisms, indicating that efficacy may be influenced by immunoregulatory factors such as autophagy, IL-8 secretion, and PDL1 overexpression. Our modeling strategy shows promise for guiding patient-specific treatment decisions and may facilitate the preselection of lung cancer patients for CAR T-cell therapy.
Improved protein binder design using beta-pairing targeted RFdiffusion
Authors: Baker David , Sappington Isaac , Toul Martin , Lee David , Robinson Stephanie , Goreshnik Inna , McCurdy Clara , Chan Tung Ching , Buccholz Nic , Huang Buwei , Vafeados Dionne , Garcia-Sanchez Mariana , Roullier Nicole , Glögl Matthias , Kim Christopher , Watson Joseph , Torres Susana Vázquez , Verschueren Koen , Verstraete Kenneth , Hinck Cynthia , Valle Melisa Benard , Coventry Brian , Sims Jeremiah , Ahn Green , Wang Xinru , Hinck Andrew , Jenkins Timothy , Ruohola-Baker Hannele , Banik Steven , Savvides Savvas
Published: January 2025

Despite recent advances in the computational design of protein binders, designing proteins that bind with high affinity to polar protein targets remains an outstanding problem. Here we show that RFdiffusion can be conditioned to efficiently generate protein scaffolds that form geometrically matched extended beta-sheets with target protein edge beta-strands in which polar groups on the target are nearly perfectly complemented with hydrogen bonding groups on the design. We use this approach to design binders against a set of therapeutically relevant polar targets (KIT, PDGFRɑ, ALK-2, ALK-3, FCRL5, and NRP1) and find that beta-strand-targeted design yields higher affinities and success rates than unconditioned RFdiffusion. All by all binding experiments show that the designs have affinities ranging from 137 pM to mid nM for their targets and essentially no off target binding despite the sharing of beta-strand interactions, likely reflecting the precise customization of interacting beta-strand geometry and additional designed binder-target interactions. A co-crystal structure of one such design in complex with the KIT receptor is nearly identical to the computational design model confirming the accuracy of the design approach. The ability to robustly generate binders displaying high affinity and specificity to polar interaction surfaces with exposed beta-strands considerably increases the range and capabilities of computational binder design.
Molecular Diversity of Dissolved Organic Matter Reflects Macroecological Patterns in River Networks
Authors: Freeman Erika C. , Mudunuru Maruti K. , Feeser Kelli L. , McClure Emily Ann , González-Pinzón Ricardo , Ward Christopher S. , Bottos Eric M. , Krause Stefan , Peña Jasquelin , Newcomer Michelle E.
Published: January 2025

Understanding the molecular complexity of dissolved organic matter (DOM) is crucial for deciphering ecosystem function and predicting responses to environmental change. Using a continental-scale dataset of molecular formulae generated by Fourier-transform ion cyclotron resonance mass spectrometry through the WHONDRS Project, we reveal fundamental scaling patterns of DOM diversity across watershed characteristics. We show that both local and regional watershed features across latitude reveal universal scaling patterns across compound classes. Our analysis demonstrates that local and regional watershed features—including drainage area, land use, land cover, and water temperature—significantly influence DOM diversity, quantified through DOM richness and chemodiversity. Notably, we document one of the first observed latitudinal gradients in freshwater chemodiversity, suggesting that macroecological factors orchestrate molecular diversity similarly to organismal distributions. These findings offer more than descriptive insights. By identifying universal scaling laws, we propose that simple predictive models can forecast compound responses to climate change, providing critical understanding of watershed functional dynamics under emerging environmental conditions. The research contributes a novel perspective on ecosystem molecular complexity, bridging biogeochemical processes with broader ecological principles and offering a quantitative framework for anticipating ecosystem molecular transformations across scales.
Unveiling microbial complexity within Astragalus propinquus and Glycyrrhiza uralensis roots
Authors: KIM Zerrin KOZMA , Park Young Sang , Yang Tae-Jin , Kim Hyun , Lee Yong-Hwan
Published: January 2025

Background
Astragalus propinquus (AP) and Glycyrrhiza uralensis (GU), members of the Fabaceae family, are widely used for their therapeutic properties. However, the endophytic microbial communities in their roots remain largely unknown. Herein, we compared the structure and properties of root-associated bacterial and fungal communities of AP and GU, specifically excluding the microbial communities thriving in the rhizosphere, using both culture-dependent and -independent methods.
Results
A metabarcoding-based approach revealed a higher abundance of Proteobacteria in the root microbiome of GU than in that of AP. Fungal communities showed similar distinctions, with AP and GU predominantly harboring Ascomycota and Basidiomycota, respectively. The bacterial community in AP exhibited significantly higher diversity than in GU and included unique taxa, e.g., Steroidobacterales and Micromonosporales. However, the bacterial community in GU was relatively less diverse and dominated by Xanthomonadales. Differential abundance analysis revealed that the plant species significantly impacted 301 bacterial and 228 fungal amplicon sequence variants (ASVs) in AP and GU. Among these, B5_f_Comamonadaceae was markedly more enriched in AP than in GU. A random forest model analyzing bacterial ASVs with significant differences in abundance indicated that most bacterial ASVs were enriched in AP. A pan-microbial community of 1,243 ASVs was identified, including 96 co-detected ASVs between AP and GU, with 3 core ASVs (B2_f_Pseudomonas, B5_Comamonadaceae, and B70_Cutibacterium). The fungal community comprised 435 ASVs, with 98 shared ASVs and 8 core ASVs (F5_Paraphoma, F6_f_Lysurus, F22_Alternaria, F30_Phaeosphaeria, F53_Cladosporium, F36_Moesziomyces, F55_f_Neocucurbitaria, and F56_Malassezia). Hub nodes were identified to elucidate the roles of microorganisms within microbial networks. In AP, B152_o_Burkholderiales, F14_Exophiala, and F33_Fusarium were the key hub nodes, whereas, in GU, B36_Paenibacillus was the central hub node. The comparative analyses of in vitro culture data and molecular sequencing results showed overlapping patterns, with Pseudomonas dominant in AP and Bacillus in GU.
Conclusions
These findings highlight distinct microbial communities between AP and GU, with each species exhibiting unique bacterial and fungal orders and differences in microbial network complexity and diversity. These differences suggest the potential functional contributions, e.g., nutrient cycling and secondary metabolite production, of root-associated microbial communities, likely impacting the therapeutic properties of these plants.
Fault Detection in IEEE 9 Bus System Using Matlab & Simulink
Authors: Kiruthika K , Vishal G , Vivek N , Mature Jyoti
Published: January 2025

This project presents a fault detection methodology for the IEEE 9-bus system using MATLAB and Simulink. The IEEE 9-bus system is a well-established testbed for studying power system stability and fault analysis due to its complexity and interconnectivity. In this study, various types of faults, including single-line-to-ground (SLG), line-to-line (LL), double-line-to-ground (DLG), and three-phase faults, are simulated and analyzed. The primary objective is to develop a fault detection mechanism that accurately identifies and classifies fault types, location, and severity within the network. The system dynamics are modeled using MATLAB’s Simulink environment, leveraging the capabilities of the Sim Power Systems toolbox for power systems simulation. The proposed fault detection algorithm employs wavelet transforms and signal processing techniques to analyze the transient response during fault conditions. By examining voltage and current waveforms at critical nodes, the algorithm pinpoint’s fault locations and classify fault types based on characteristic transient features. The findings of this research are essential for advancing the reliability of protection systems, as the early detection of faults minimizes system downtime and ensures stable power delivery. The project concludes with a performance analysis of the fault detection approach, illustrating its effectiveness and accuracy across different fault scenarios in the IEEE 9-bus model.
OR7E47P regulates TGF-β secretion of fibroblast via ROBO2 pathway to modulate the TME in NSCLC
Authors: Zhang Haohan , Wu Jie , Li Lan , Li Jing , Zhao Xinyi , Zhong Hao , Dan Yuchao , Mao Zhangfan , Song Qibin , Xu Bin
Published: January 2025

Whereas the role of OR7E47P in NSCLC is not clear, we explored the impact of OR7E47P on the prognosis of NSCLC patients and possible mechanisms through bioinformatics and experi-mental approaches. OR7E47P, underexpressed in NSCLC tumor tissues, is associated with better prognosis and enhanced immune benefits. Localization analyses showed OR7E47P may func-tions as a cytoplasmic processing pseudogene, regulating ROBO2 expression via the OR7E47P/miR-183-5p/ROBO2 pathway at the post-transcriptional level. Single-cell analyses re-vealed that ROBO2 reduces the tumor-supportive role of cancer-associated fibroblasts (CAFs) by promoting programmed cell death of FAP/TGFB1 + CAFs, enhancing immune infiltration, and suppressing the TGF-β/Smad signaling pathway in fibroblasts and NSCLC cells. Finally, we con-firmed our findings through experiments, where OR7E47P directly binds to miR-183-5p, with a binding site that allows for endogenous competition, leading to the upregulation of ROBO2 ex-pression and potentially regulate TGF-β secretion of fibroblast, thereby regulating the TME in NSCLC.
Fractons on curved spacetime in 2 + 1 dimensions
Authors: Hartong Jelle , Palumbo Giandomenico , Pekar Simon , Perez Alfredo , Prohazka Stefan
Published: January 2025

We study dipole Chern–Simons theory with and without a cosmological constant in 2+12+1 dimensions. We write the theory in a second order formulation and show that this leads to a fracton gauge theory coupled to Aristotelian geometry which can also be coupled to matter. This coupling exhibits the remarkable property of generalizing dipole gauge invariance to curved spacetimes, without placing any limitations on the possible geometries. We also use the second order formulation to construct a higher dimensional generalization of the action. Finally, for the (2+1)(2+1)-dimensional Chern–Simons theory we find solutions and interpret these as electric monopoles, analyze their charges and argue that the asymptotic symmetries are infinite-dimensional.
Craniocevricalgia
Authors: Maximova M. Yu. , Suanova E. T.
Published: January 2025

Сraniocervicalgia is a collective clinical term that unites pain syndromes localized in the occipital and cervical area, which can spread to the frontal, temporal and orofacial areas. Clinically, the most common types of сraniocervicalgia are cervicogenic headache (CH), neck pain caused the temporomandibular joint dysfunction and craniocervicalgia caused of the vertebral arteries dissection. Diagnosis of craniocervicalgia should be based on the diagnostic criteria of the International Classification of Headache Disorders, 3rd revision (2018) with an analysis of the individual pain features. The characteristic of the CH is defined in the name itself. The most significant point is dysfunction of the three upper cervical segments. Pathological changes in the anatomical structures of the spinal column (facet joints, annulus fibrosus, ligaments, periosteum), muscles and tendons innervated by the upper cervical segments may be the source of CH. The convergence of the upper cervical sensory nerves (C1-C3) and trigeminal nerve fibers in spinal trigeminal nucleus at the upper cervical segments is believed to be more important for the development of CH. Usually, it`s a dull, aching, unilateral pain, which is provoked by a prolonged forced head position (uncomfortable posture) and movements in the cervical spine (turns, tilts of the head). Cervical movement restrictions in one or more directions is noted. In general, the diagnosis is mainly based on clinical examination, but can be confirmed by a diagnostic blockade of the cervical facet joints, after which patients can get partial or complete pain relief. We present a clinical case with a typical progress of CH. The patient was recommended daily 15–30 minute exercise therapy, hourly a few exercises for activation and stabilization of the cervical spine muscles, and increase general physical activity. Symptomatic treatment with a non-steroidal anti-inflammatory drug was prescribed – Nurofen Express Forte, containing 400 mg of ibuprofen in a capsule with liquid contents, twice a day for 2 weeks. During a follow-up examination after 15 days, the patient reported a pain relief at rest, the maximum pain intensity according to the visual analog scale decreased from 5 to 1 mm during movement. The patient’s general well-being and tolerance to prolonged postural tension significantly improved. Further recommendations included a training program for spine stabilization the and muscles endurance. After 3 months of patient observation, a therapeutic stability was noted. Considering the high antinociceptive efficacy of Ibuprofen, use of Nurofen Express Forte should be recommended in the complex treatment of patients with CH.
Insomnia in peri-menopausal and post-menopausal women and in some somatic diseases
Authors: Pizova N. V. , Pizov A. V.
Published: January 2025

Insomnia is becoming increasingly common in modern society and leads to significant issues for people’s health and well-being. Sex differences in sleep begin at an early age and continue throughout life. At the same time, women report poorer sleep quality and have higher risk for insomnia than men. Some studies show that men and women differ in their neurohormonal secretion, biological processes, and brain morphology. A significant number of women experience sleep difficulties in the approach to menopause and beyond, with the most common symptoms being difficulty in initiating sleep, short sleep duration, and poor sleep quality. The aetiology of sleep disorders in postmenopausal women isn’t yet still clear and seems to be different according to the specific symptoms of sleep disorder. However, potential factors include menopause itself, ageing, vasomotor symptoms, depression, anxiety, and many other diseases such as cardiovascular, endocrine, and psychosocial factors. Insomnia may occur alone or with other medical or mental health conditions. If left untreated, it may increase the risk for developing and worsening any of these conditions. Menopause is often associated with elevated risks of cardiovascular diseases. Insomnia is considered as an established risk factor for myocardial infarction, including in women. Sex differences have been detected in studies of sleep problems, with significant associations in women with regard to hypertension, the prevalence of dyslipidaemia, obesity, and diabetes. Diagnosis of insomnia is largely based on skilled history taking. Insomnia treatment is based on two strategies that may be used isolatedly or in combination: cognitive behavioural therapy for insomnia and pharmacological treatment.
Uma jornada de descobertas: a transformação através do estágio em sociologia
Authors: MARIA SILVA OLIVEIRA PRISCILA
Published: January 2025

O relato de experiência aborda o estágio supervisionado em Sociologia, realizado como parte da Segunda Licenciatura, que proporcionou uma profunda imersão no contexto social de uma escola pública em um bairro de vulnerabilidade social. Destaca-se a importância da Sociologia na formação crítica dos alunos, ressaltando como a disciplina pode transformar vidas ao permitir que estudantes reflitam sobre suas próprias realidades.
Ao longo do estágio, observei as dificuldades enfrentadas pelos alunos, incluindo pobreza e exclusão social, e o desafio de engajar os estudantes em temas complexos da disciplina. Apesar da limitação de tempo e recursos, as aulas promoveram discussões significativas, revelando o impacto transformador da Sociologia na vida dos jovens.
A experiência também trouxe reflexões sobre o papel do professor, que vai além de ensinar conteúdo, inspirando e motivando os alunos a serem protagonistas de suas histórias. O estágio reafirmou meu compromisso com a docência, ressaltando a importância da empatia, sensibilidade e vontade de contribuir para uma sociedade mais justa.
Estágio Supervisionado em Geografia no Instituto de Aplicação Fernando Rodrigues da Silveira
Authors: Moraes Vinícius
Published: January 2025

O presente artigo tem como objetivo central apresentar a especificidade do Estágio Supervisionado Curricular no processo de formação de professores de Geografia na Universidade do Estado do Rio de Janeiro. Parte significativa desse percurso formativo é realizado no Instituto de Aplicação Fernando Rodrigues da Silveira – CAp-UERJ, e apresenta particularidades que apontam para potencialidades pedagógicas na construção de identidades docentes. O artigo está dividido, excluindo as considerações iniciais, em três momentos: primeiro, faço algumas observações sobre a relevância pedagógica do Estágio Curricular Supervisionado; em seguida, apresento as particularidades do caminho do Estágio Supervisionado no CAp-UERJ; e, por último, compartilho algumas reflexões sobre o processo de formação das identidades docentes.
Qualidade do solo e percepção socioambiental de produtores e agentes rurais no cultivo de fumo em Pilões/RN
Authors:   , Pontes Nadja Cristina
Published: January 2025

A qualidade ambiental tem sido bastante discutida em decorrência da conscientização humana do uso sustentável dos recursos naturais, ainda que restritas ações de conservação estejam sendo desenvolvidas. No panorama de impactos ambientais provenientes da agricultura é comum observar a diminuição da qualidade do solo e a dificuldade de quantificar a perda desses atributos bem como a percepção socioambiental dos principais atores do âmbito rural Diante dessa problemática, objetivou-se avaliar os atributos químicos do solo em áreas de cultivo de fumo com base em índice de qualidade ambiental do solo, bem como avaliar o impacto socioambiental dessa atividade segundo a percepção de produtores e agentes rurais do município de Pilões/RN através de entrevistas semiestruturadas. Foi possível conferir melhoria da qualidade ambiental para P, Ca, Mg e Al em relação à mata nativa, diferentemente das alterações verificadas para CE, pH e Al+H, que não apresentaram resultados favoráveis à qualidade do solo. Conforme a percepção socioambiental dos produtores e agentes rurais, o cultivo de fumo alterou negativamente o ambiente em que vivem apesar desses agricultores conhecerem boas práticas para a preservação do solo. De acordo com os entrevistados a principal insatisfação gerada pela empresa fumageira instalada no município foi a ausência de aporte ao desenvolvimento social de Pilões, contudo a fumicultura representou maior fonte de renda e geração de empregos para o município de Pilões.
Dinámica migratoria y gobernanza humanitaria: un análisis integral de la crisis fronteriza entre Estados Unidos y México
Authors: Ramos García José María , Ramos Valencia Jimmy Emmanuel
Published: January 2025

Este artículo investiga las complejas dinámicas migratorias y la gobernanza humanitaria en la frontera entre Estados Unidos y México, específicamente en las ciudades de Tijuana, Nogales, Ciudad Juárez y Piedras Negras, en el norte de México. El estudio presenta datos detallados de la Oficina de Aduanas y Protección Fronteriza de los Estados Unidos (USCBP), que incluyen 6.83 millones de encuentros con migrantes irregulares entre enero de 2021 y octubre de 2023. Este artículo enfatiza la influencia de las políticas migratorias recientes de EE. UU., en particular durante la administración del presidente Biden, y los desafíos en la gestión del aumento en los flujos migratorios. También, examina el papel crítico de las organizaciones de la sociedad civil, las limitaciones de los albergues y la necesidad de esfuerzos coordinados entre gobiernos, ONG y agencias internacionales. Al analizar los obstáculos relacionados con la gobernanza humanitaria, incluyendo preocupaciones de seguridad, recursos limitados y cooperación transfronteriza, el estudio contribuye a la discusión más amplia sobre migración, abogando por un enfoque equilibrado y humano que integre derechos humanos y medidas de seguridad en las estrategias de gestión fronteriza.
Developing and Assessing a Scalable Digital Health Tool for Pretest Genetic Education in Patients With Early-Onset Colorectal Cancer: Mixed Methods Design
Authors: Rivera Rivera Jessica N , Snir Moran , Simmons Emilie , Schmidlen Tara , Sholeh Misha , Maconi Melinda Leigh , Geiss Carley , Fulton Hayden , Barton Laura , Gonzalez Brian D , Permuth Jennifer , Vadaparampil Susan
Published: January 2025

Background

National guidelines recommend germline genetic testing (GT) for all patients with early-onset colorectal cancer. With recent advances in targeted therapies and GT, these guidelines are expected to expand to include broader groups of patients with colorectal cancer. However, there is a shortage of genetic professionals to provide the necessary education and support for informed consent. As such, there is a pressing need to identify alternative approaches to facilitate and expedite access to GT.

Objective

This study describes the development of a pretest education intervention, Nest-CRC, to facilitate the uptake of germline GT among patients with early-onset colorectal cancer. Patients with early-onset colorectal cancer and health care providers reviewed Nest-CRC, and their reactions and recommendations were captured using a nested mixed methods approach.

Methods

Using the learner verification approach, we conducted 2 sequential phases of surveys and interviews with English- and Spanish-speaking patients with early-onset colorectal cancer and health care providers. The surveys assessed participants’ experiences with genetic services and provided immediate feedback on the Nest-CRC genetic education modules. Semistructured interviews evaluated participants’ perceptions of self-efficacy, attraction, comprehension, cultural acceptability, and usability of Nest-CRC. Survey data were analyzed using descriptive statistics (mean, median, and proportions), while interview data were analyzed through line-by-line coding of the transcribed interviews. After each phase, Nest-CRC was refined based on participants’ recommendations.

Results

A total of 52 participants, including 39 patients with early-onset colorectal cancer and 13 providers, participated in the study. Of these, 19 patients and 6 providers participated in phase 1 (N=25), and 20 patients and 7 providers participated in phase 2 (N=27). Most participants (phase 1: 23/25, 92%, to 25/25, 100%; phase 2: 24/27, 89%, to 27/27, 100%) agreed that each of the 5 education modules was easy to understand and helpful; 13 patients reported no history of GT, with 11 (85%) expressing interest in GT and 2 (15%) remaining unsure after completing Nest-CRC. Participants reported that Nest-CRC provided sufficient information to help them decide about GT. The tool was deemed acceptable by individuals from diverse backgrounds, and participants found it visually attractive, easy to comprehend, and user-friendly.

Conclusions

The findings revealed that Nest-CRC is a promising strategy for facilitating pretest education and promoting GT. Nest-CRC has been refined based on participant recommendations and will be re-evaluated.
Effects of a virtual reality-based mindfulness intervention on well-being among dementia family caregivers: pilot randomized controlled trial (Preprint)
Authors: Bai Dorothy , WANG Yu-Hua , LIN Yu-Fang , Liu Megan F.
Published: January 2025

BACKGROUND

Dementia caregiving imposes significant burdens, causing physical and psychological stress. Existing support programs often fall short in addressing these challenges. While mindfulness-based interventions are suggested to reduce stress and improve caregivers' quality of life, the effect of combining them with virtual reality (VR) technology in health-related areas remains underexplored among dementia caregivers.

OBJECTIVE

In this study, we aimed to investigate the effects of a VR-based mindfulness intervention on depression, sleep quality, and overall quality of life among family caregivers of people with dementia.

METHODS

This pilot study employed a parallel randomized controlled trial design and followed recommendations of the CONSORT checklist. Participants were equally divided into intervention and control groups. The intervention group underwent a 6-week VR-based mindfulness intervention, integrated with VR technology, encompassing practices such as breathing observation, body scanning, mindful yoga, mindful walking, and holistic meditation, with each session lasting 40~60 minutes. The control group received an audio-guided mindfulness program. Primary outcomes were changes in depression measured by the Center for Epidemiologic Studies Depression Scale (CES-D), sleep quality assessed by the Chinese Pittsburgh Sleep Quality Index (CPSQI), and QOL evaluated by the WHOQOL-BREF Taiwan version. Data were collected at the baseline and post-intervention by trained researchers blinded to group assignments.

RESULTS

Sixteen participants (with a median age of 56 years) were enrolled and analyzed. In this study, both the intervention group, who experienced a VR-based mindfulness intervention, and the control group, who received an audio-guided mindfulness program, demonstrated significant within-group improvements in depression (intervention: -4.50; P=.012; control: -4.00; P=.012), sleep quality (intervention: -1.50; P=.012; control: -1.50; P=.012), and overall QOL (intervention: 2.00; P=.012; control: 3.00; P=.012). However, the comparative analysis revealed no significant differences between the two groups in these outcome measures.

CONCLUSIONS

Both VR-based and audio-guided mindfulness interventions significantly improved depression, sleep quality, and quality of life among dementia caregivers, with no significant differences between groups. These findings highlight the potential of VR technology in mindfulness practices, warranting further research with larger samples.

CLINICALTRIAL

NCT06034249
Portuguese Azulejo: A Transcultural Odessey of the East and the West
Authors: Shen Xinxin
Published: January 2025

This research focuses on the art of Portuguese azulejo. Originating in Moorish Andalusia during the medieval period, azulejo manifests as architectural ornamentation, tiled murals, and various forms of decorative painting. Their transmission to Portugal led to the development of uniquely Portuguese tiled panel artistry. During the Ming and Qing dynasties, East-West cultural exchanges resulted in the integration of Chinese blue and white porcelain artistry into Portuguese azulejo, impacting their colors, styles, and aesthetics. To this day, Portuguese azulejo artistry stands as a cultural heritage and a national cultural symbol. Therefore, the history of azulejo is indeed a transcultural history of art.
Usuarios de los sistemas de información geográfica de la Universidad Nacional Autónoma de México: el comportamiento informativo de los investigadores
Authors: Santos Rosas Antonia , Calva González Juan José
Published: January 2025

Se brindan los resultados de una investigación en torno al comportamiento informativo del personal investigador como usuarios de los sistemas de información geográfica (SIG) del Instituto de Geografía de la Universidad Nacional Autónoma de México. Este tipo de usuarios ocupa el primer lugar de uso de estos sistemas en comparación con otros usuarios, a saber, técnicos académicos y estudiantes. Además, cabe mencionar que el objeto de estudio de estos investigadores es el espacio geográfico, donde el mapa constituye una fuente básica de información. El planteamiento del problema para esta investigación parte de las siguientes interrogantes: ¿Cuál es el perfil de los investigadores como usuarios que utilizan los sistemas de información geográfica? ¿Cómo es el comportamiento informativo de los investigadores como usuarios de los sistemas de información geográfica en el Instituto de Geografía de la Universidad Nacional Autónoma de México? ¿Cuáles son las variables del comportamiento informativo en el uso de los programas informáticos de sistemas de información geográfica? ¿De qué maneras el personal de las bibliotecas puede apoyar al investigador como usuario de los sistemas de información geográfica? Se aplicó una metodología cualitativa, la técnica de grupo focal.
Design, Characterisation and Evaluation of Sustained Release Formulation of Remogliflozin Etabonate
Authors: Aveek Datta  , Dr. Subhasis Maity  , Dr. Miltu Kr. Ghosh  , Dr. Kuntal Hazra
Published: January 2025

Now-a-days Type 2 diabetes mellitus is a very crucial common disease and emerging condition that glucose level of Human body cannot be controlled. In case of Type-2 diabetes mellitus, pancreas does not produce enough insulin. In such a condition, we have to thing for a medicament for treating the disease; Remogliflozin Etabonate is such type of drug that efficacious and safe agent that we can administer in our body. The Half-Life of the drug is 120 minutes.This research has taken into consideration on improving the release pattern of the drug by sustaining its action at maximum level of time, using the different ratios of Polymer and discusses the individual studies performed during its development for design, characterization and evaluation of analytical and formulative profile, as well as in-vitro Characterization. In that case, this research work is hopefully very much  useful for further proceeding and for large scale aspect in industrial point of view.
Review on Psoriasis and Their Managments
Authors: Tejaswini G.Khonde  , Sakshi P. Waikar  , Nilakshi N. Dhoble  , Nitin Padole  , Pankaj Dhapke  , Jagdish R. Baheti
Published: January 2025

Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. The pathogenesis of psoriasis includes genetics, environmental factors, lifestyle causes. Diagnosis of psoriasis can be done by self-examination or skin biopsy and in some cases differential diagnosis may be required. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessive skin cell growth. Psoriasis cannot be cured but there are effective treatment options available. Attempts have been made in this review to focus on the etiology, pathophysiology, diagnostic methods and treatment options which may be used for psoriasis patients worldwide.
Formulation Evaluation and Comparative Study of Herbal Mouthwash with Marketed Preparation
Authors: Aman Mohata  , Seema Wakodkar  , Jagdish Baheti
Published: January 2025

The current study aims to create and assess a herbal mouthwash and assess its efficacy in combating the oral cavity's microbial load. To extract the hydroalcoholic and water-soluble components, plant materials were gathered. Piper nigrum seeds and hibiscus flowers were used to prepare herbal mouthwash for extraction. The prepared mouthwash's pH, antibacterial activity, and physicochemical characteristics were further assessed. The mouthwash that is currently available has good antibacterial qualities. Currently, available mouthwash is a liquid formulation that often includes antiseptic and antibacterial ingredients. The major benefits of utilizing mouthwashes are that they can be used regularly at home to maintain good oral hygiene, that they have antibacterial activity, that they can be used as prophylaxis before and after oral surgery procedures like tooth extractions, and that they clean teeth after brushing. These solutions may be used for various purposes, such as their analgesic, anti-inflammatory, or anti-fungal properties, in addition to their ability to lessen microbial development, gingivitis, and halitosis in the oral cavity.
Immunological criteria for the diagnosis of multisystem inflammatory syndrome associated with MERS-COV-2 and infectious diseases with sepsis in children
Authors: Konstantinovа Yu. E. , Zhirkov A. A. , Alekseeva L. A. , Vilnits A. A. , Bessonov T. V. , Zhdanov K. V.
Published: January 2025

Multisystem inflammatory syndrome associated with SARS­CoV­2 in children is a potentially life–threatening condition that develops several weeks after COVID­19 and is characterized by a hyperinflammatory response with damage to ≥2 organs and systems. At the moment, there is no understanding of how the mechanisms of development and course of this disease differ from other more studied similar conditions, for example, sepsis in infectious diseases.

The aim is to compare immunological parameters in multisystem inflammatory syndrome associated with SARSCoV­2 and infectious diseases with sepsis in children.

Materials and methods. The concentration of cytokines, chemokines and growth factors in serum was determined in 14 children with multisystem inflammatory syndrome associated with SARS­CoV­2, 19 children and 16 healthy children (control group) with IHS.

Results. Both common and distinctive signs of inflammation were found in patients with MVS­D and IHS. Patients with MVS­D, unlike healthy children, were characterized by a decrease in Basic FGF, IFN­a2, IL­1a, IL­1b, IL­2, IL­3, IL­4, IL­5, IL­9, IL­12(p40), IL­13, IL­18, PDGF­BB, RANTES, TRAIL and Boost G­CSF, HGF, IL­1ra, IL­2Ra, IL­6, IL­10, IL­16, IP­10, MCP­1, M­CSF, MIG. Statistically significant in MVS­D was a decrease in IL­2 and IL­5 levels compared with the control group, but significantly less pronounced than in IS (8.0 times and 3.5 times, respectively), a pronounced increase in MIG levels (12.0 times compared with children with IS). The RANTES index (a proinflammatory chemokine that attracts leukocytes to the focus of inflammation) decreased with MVS­D, while it increased with IS compared with the control group.

Conclusions. Immunological features of MISC have been found that distinguish the pathogenesis of the syndrome from infectious diseases occurring with sepsis. The identified markers can be used as criteria for the differential diagnosis of these diseases.
Influenza vaccination and cytokine profile dynamics in young men in Primorsky krai
Authors: Li Yu. A. , Dmitrachenko M. N. , Kostinov M. P. , Markelova E. V. , Korolev I. V. , Saprykin S. L.
Published: January 2025

Seasonal vaccination against influenza is considered the most effective method of specific prevention of this infection. However, in recent years, the issue of non­specific, training effects of vaccines on the immune system has been widely studied. One of the mechanisms of implementation may be a change in the production of cytokines in vaccinated people.

Purpose of the study: to study the dynamics of pro­inflammatory and anti­inflammatory cytokines before and after vaccination against influenza.

Materials and methods: The study involved 75 young men, the average age was 18.7±0.8 years, who were vaccinated with the Sovigripp vaccine. Those included in the study had two blood samples: (1) – before the flu vaccination; (2) – one month after the flu vaccination. Serum levels of proand anti­inflammatory cytokines were determined by solid­phase enzyme immunoassay: IL1β, IL4, IL6, IL8, IL10, IL17, IFNγ, TNFα. The results were recorded using an automatic enzyme immunoassay analyzer. Statistical processing of the obtained results was carried out using the STATISTICA 10 software package.

Results: In the analysis of cytokines before vaccination, an increase in IL8, IL17 and IL6 levels was detected in 100% of cases – in 76% of cases. Within the generally accepted norms, only TNFa was determined in 92% of the surveyed population. The remaining indicators were reduced: IFNγ – in 100%, IL1β and IL4 – in more than 80% and IL10 – in 50% of cases. After influenza vaccination, there was a noticeable tendency to decrease the levels of all cytokines compared to baseline values.

Conclusion: The results of the study revealed features in cytokine levels before and after influenza vaccination in healthy young people, which were characterized by deviations from the norm in both directions.