bluuebunny/crossref_metadata_2025 huggingface dataset:
WITHDRAWAL OF THE CHARGE BY THE PUBLIC PROSECUTOR IN THE CONTEXT OF ENSURING PROCEDURAL FREEDOM OF THE JUDGE
Authors: Гизатуллин Ирек Альфредович
Published: August 2022

Abstract. The article criticizes the obligation of the court to discontinue criminal proceedings or prosecutions if the public prosecutor refuses to prosecute in terms of preventing such consequences from obstructing the court’s unique function of resolving a criminal case. The purpose of the work is to develop theoretical provisions justifying the need for legislative improvement of the public prosecutor’s withdrawal of the charge in order to ensure the procedural independence of judges. The article uses the methods of system analysis, synthesis, sociological survey and generalization. Results: on the basis of the analysis of criminal case files and the results of the judges' questionnaires, it is proved that the lack of an alternative effect of the public prosecutor’s withdrawal of prosecution is an unjustified restriction of the judge’s discretion in making the final decision and the lack of a real possibility for the court to ensure the procedural interests in the actual presence of sufficiently accurate grounds. In this part, the author compares criminal proceedings to civil and arbitration proceedings, noting that the plaintiff’s waiver is possible only if it does not violate the fundamental principles of justice and the interests of third parties. It is proposed to remove from the law the rule of mandatory dismissal of a criminal case when the public prosecutor withdraws the charge, and to leave the matter to the reasoned discretion of the court, as it was done in the Statute of Criminal Procedure of 1864.
Mathematical Modeling Application in Energy Conversion and Energy Storage
Authors: DELİBAŞ Nagihan , HOSSEİNİ Seyyedreza , NİAİE Aligholi
Published: August 2022

The use of mathematical modeling to predict and investigate the effect of process variables in the research and engineering field of energy conversion and energy storage has also received special attention from scientists and industrial designers in this field due to their importance in the global economy. This review article investigates the applications of mathematical modeling and simulation in energy conversion and energy storage processes, and finally, with a case study, the application of mathematical modeling in the desired processes to be tested and compared with the reported results in the papers. In the first part, the main emphasis is on energy conversion, especially on the structure of solar cells and fuel cells and mathematical modeling methods, and predicting the effect of operating variables on their performance. The basic principles of modeling solar cells and fuel cells to understand the relationships governing the current, voltage, performance, and power of PV modules are to be discussed. And with a case study, modeling of the process to estimate the performance of PV modules and SOFC in various conditions has been investigated. In the second part, the main focus is on the mathematical modeling of energy storage devices including batteries and supercapacitors. Supercapacitors and batteries are electrochemical energy storage devices that can be charged within a few seconds to a few minutes. This efficient energy storage is based on the electrocatalytic effect of the electrode with a high surface area. The mathematical equations governing the battery and supercapacitor are discussed in the article, and battery and supercapacitor performance are to be simulated as a case study. Due to the Multiphysics nature of energy conversion and storage systems, the simulation is performed in two stages. In the first step, the semiconductor equations are applied and the electrical response of the electrochemical device is modeled. In the second step, if needed, the thermal equations can be entered into the main calculations and the net amount of heat and the temperature profile in the desired device is evaluated. The main goals and ideas of compiling this review article are expressing the importance and role of electrochemical and electrocatalysts in energy production and storage processes and paying attention to the governing mechanism and mathematical equations and highlighting important and common models used in different parts of energy conversion and storage in a coherent article.
New Travelling Wave Solutions of Conformable Cahn-Hilliard Equation
Authors: AKSOY Esin , ÇEVİKEL Adem
Published: August 2022

In this article, two methods are proposed to solve the fractional Cahn-Hilliard equation. This model describes the process of phase separation with nonlocal memory effects. Cahn-Hilliard equations have numerous applications in real-world scenarios, e.g., material sciences, cell biology, and image processing. Different types of solutions have been obtained. For this, the fractional complex transformation has been used to convert fractional differential equation to ordinary differential equation of integer order. As a result, these solutions are new solutions that do not exist in the literature.
Nias Dance Encyclopedia as a Source of the Working Process
Authors: Sibuea Tuti Rahayu , Wiflihani
Published: August 2022

This study aims to develop an encyclopedia on the concept of traditional dances from Nias ethnic groups in North Sumatra as a source of learning in the process of creating. This research is directed at a reference book product in the form of an encyclopedia. From this research process, the results of the development of a reference book for the local traditional dance of Nias, North Sumatra emerged. This research uses research and development (Research and Development or R&D) methods. The location or place in this study was carried out in the cities of Medan and Nias with data collection techniques obtained through observation, in-depth interviews and documentation. After all the required data have been completed, the next step is to analyze the data using a qualitative paradigm using project based research, which is obtained through data reduction,The average value obtained during the material expert feasibility test was 4.75 with a very good category and no revision. The average value obtained at the time of this media feasibility test was 4.375 with a very good category.The results of the development of this Nias traditional dance encyclopedia book can be used as a reference for students and the community as a source of the creative process for Nias traditional dances.
Patrimonio alimentario, fundamento para el desarrollo del turismo étnico
Authors: Inga Aguagallo Carlos Fernando , Zurita Gallegos Ronald Mauricio , Badillo Arévalo Pedro Arturo , Garrido Patrel Andrea Margarita
Published: August 2022

Introducción: El patrimonio cultural alimentario, constituye la conexión entre el pasado y el presente de la sociedad desde un análisis culinario y gastronómico, no solo es oportuno el discutir el origen de un platillo o bebida, es necesario profundizar en el todo, incluyendo el cultivo, cosecha, comercialización, trazabilidad, producción alimentaria, cosmovisión, representatividad, memoria individual y colectiva, entre otros factores propios del efecto cultural. Objetivos: Determinar las características del patrimonio alimentario y su relación con el turismo étnico en la provincia de Chimborazo. Metodología: Se utilizó la investigación documental, descriptiva y de campo, ejecutada en la provincia de Chimborazo, en la cual, se han priorizado 4 comunidades donde se han apreciado grandes aportes en el plano del turismo de raíz también conocido como étnico, donde se ha recolectado información mediante la aplicación de fichas de registro del patrimonio alimentario (PA) y entrevistas con los custodios de los saberes y dirigentes comunitarios. Resultados: Se enlistó parte de la riqueza alimentaria que posee la provincia, así como también la contribución que tienen los saberes ancestrales alimentarios en el desarrollo del turismo étnico. Conclusiones: El estudio permite poner en valor la cultura alimentaria, reconocer la variada y amplia oferta en el medio y del mismo modo, se determinó el alcance generado por el aprovechamiento del producto alimentario en las comunidades donde por medio del turismo étnico se han creado fuentes de empleo.
Program Kemitraan Masyarakat Melalui Penyuluhan Penyusunan Laporan Keuangan dan Pemasaran Digital di UD Artha Guna Sasih Bali pada Masa Pandemi Covid-19
Authors: Sutapa I Nyoman , Idawati Ida Ayu Agung , Suryanditha Putu Arya
Published: August 2022

This community service program aims to improve the ability of partners in compiling financial reports in accordance with applicable standards, increase the ability of partners to use digital marketing, and increase understanding about maintaining health when work in building stores. The implementation method is by providing training, counseling and mentoring. Subject in this program is Artha Guna Sasih’s owners and employees. Instrument of this program is using the shared questionnaire before and after execution. The evaluation stage is carried out by seeing whether there is an increase in understanding of the non-collectible receivables, the financial management field will provide counseling on how to do good marketing by utilizing digital marketing and the medical field will provide counseling on how to maintain health in the midst of a pandemic and hazardous substances contained in building materials such as cement. The results of the service will provide counseling on how to make non-collectible receivables, the financial management field will provide counseling on how to do good marketing by utilizing digital marketing and the medical field will provide counseling on how to maintain health in the midst of a pandemic and hazardous substances contained in building materials such as cement.
Pelatihan Bekam (Al Hijamah) Sebagai Upaya Mewujudkan Kampung Sehat Pada Masa Pandemi Covid-19 di Desa Perengge Kabupaten Lombok Barat
Authors: Atika Baiq Naili Dewi , Risfianty Dwi Kartika , Sanuriza Irna Il , Ihwan Khaerul , Anggraeni Dara Puspita
Published: August 2022

This community service activity aims to increase people's knowledge of how to do cupping properly and correctly, to create a healthy village during the pandemic, and as an effort to prevent the transmission of COVID-19 by promoting and preventive health measures. The method of implementing this service activity is by combining theories (discussion) 25% and practice 75%, as well as entrepreneurial provisions. There were 25 participants in the training. The evaluation instruments used were interviews, observation, and documentation. After all series of activities were carried out, the results of the service activity showed that the majority of participants had mastered the pre-cupping, cupping, and post-cupping procedures following the rules and procedures for the safety of the medical world.
Diseminasi Media Pembelajaran Berbasis Flippbook untuk Mendukung Asyncrhonous Learning di SMP-SMA Bunda Kandung Jakarta
Authors: Triyono Ageng , Nurimani Nurimani , Nuary Rusdi Hamdany , Wibowo Teguh
Published: August 2022

The purpose of this community service is to develop teaching materials to meet the learning needs of asynchronous learning. The teaching materials developed are in the form of electronic modules and electronic worksheets based on flipbooks. The service method carried out is in the form of a dissemination program whose stages are carried out in a hybrid manner. The service stages consist of the stage of developing teaching materials which are carried out offline and is followed by the stage of socializing and monitoring which is carried out online. The target of this service is the mathematics teacher at Bunda Kandung Middle and High School, Jakarta. The activity evaluation instrument is in the form of a questionnaire. The results of the questionnaire showed that the teacher as the party receiving the benefits stated that he was satisfied with the media developed and the media could be used as an alternative solution to the current needs of teaching materials. The results of the monitoring phase indicated that the teaching materials developed have begun to be implemented and have succeeded in meeting the needs of teaching materials needed by schools. So, it can be concluded that this activity has succeeded in achieving the expected goals.
GELENEKSEL KOOPERATİF YAPISININ KURUMSAL YÖNETİM AÇISINDAN İNCELENMESİ
Authors: KALKAN Göktürk
Published: August 2022

Yardımlaşma ve dayanışma temelinde üyelerinin ihtiyaçlarını karşılamayı amaç edinen ve bir üye-bir oy ilkesiyle çok sayıda üyenin sahip olduğu geleneksel kooperatifler, toplumda mülkiyetin tabana yayılmasını sağlayabilecek ve böylece gelir dağılımı adaletsizliğini azaltmaya katkıda bulunabilecek önemli bir işletme türüdür. Sermaye şirketlerine göre çok sayıda ortağının olması ve bu ortaklarının çok çeşitli hedeflerinin olması, kooperatifi yönetecek yönetim kurulunun bu ortaklar içinden seçilmesi ve böylece karar kontrolü ve karar yönetimi fonksiyonlarının birbirinden ayrılması sonucunda ortaya çıkabilecek çıkar çatışmaları, bunun yanında kendine özgü yapısından dolayı ortaya çıkan bedavacılık, ufuk, portföy, kontrol ve etki maliyetleri gibi sorunlar geleneksel kooperatiflerin etkin bir şekilde yönetilmesini zorlaştıran durumlardır. Bütün paydaşların hedeflerini uyumlaştırmayı ve aralarındaki çıkar çatışmalarını azaltmayı amaç edinen kurumsal yönetim, kooperatiflerin etkin bir şekilde yönetilmelerine katkıda bulunabilecek bir yönetim anlayışıdır. Sahiplik yapısı, yönetici mali hakları, yönetim kurulu ve finansal açıklama, dış şirket devralma piyasası, yasal altyapı ve ürün piyasası rekabeti gibi kurumsal yönetim mekanizmaları da özellikle paydaşlar arasındaki çıkar çatışmalarını azaltarak, kooperatiflerin iyi yönetilmelerine katkıda bulunabilecek ve böylece toplumsal refah artabilecektir.
Clinical Presentation and VRT-CT Features in Pediatric Patients with COVID-19 Infection
Authors: Solgun Hüseyin Avni , Yurdaisik Isil
Published: August 2022

Objective: The aim of this study is to discuss the clinical, laboratory, chest computed tomography (CT) and volumetric imaging technique (VRT) features in pediatric patients with novel coronavirus 2019 (COVID-19) infection. Material and Methods: The clinical, laboratory, and chest CT features of 17 pediatric patients with COVID?19 infection those confirmed by pharyngeal swab COVID?19 polymerase chain reaction(PCR) were evaulated. All clinical and laboratory data have been recorded and analyzed during march-february 2021 . Chest CT have been performed to all Covid 19 PCR confirmed patients and radiologicall view have been noted. Results: Seventeen pediatric patients with a history of close contact with COVID?19 diagnosed family members included to the study. Fever (10/17, 58%) and cough (13/17, 76%) were the most common symptoms. For laboratory findings, c reactive protein elevation (15/17, 88%) seem to be the most finding. A total of 4 patients presented with unilateral pulmonary lesions (4/17, 23%), 9 with bilateral pulmonary lesions (9/17, 52%) and 13 cases showed bilateral diffuse covid pattern on chest CT (13/17, 76%). Non-spesific consolidation with was observed in 8 patients (8/17, 47%), ground?glass opacities were observed in 11 patients (11/17, 64%), nodules were observed in 7 patients (7/17, 41%), and tiny nodules were observed in 2 patients (2/17, 11%). Conclusion: In pediatric patients before confimation positivitiy of COVID?19 nucleic acid test from pharyngeal swab samples; the early detection of lesions with chest CT especialy by VRT (volumetric rendering technique)-CT tecnique can be efficient; in management and early treatment for pediatric patients. More clinical trails can suggest about the primeline screening and treatment options in pediatric covid-19 infection in future.
Factors Driving Pregnant Women’s Participation in Non-therapeautic Clinical Research in Tanzania: Qualitative Findings from Mwananyamala Regional Hospital, Dar-Es-Salaam Region
Authors: Siyajali Bonaventura P. M , Kamazima Switbert R , Raymond Athanas
Published: August 2022

Background: Pregnant women’s participation in non-therapeutic clinical trials has gained global attention. However, the imposition of unnecessary harm to the fetuses because of their participation is questionable. This is proved by the historical tragedies that resulted from the use of diethylstilbestrol and thalidomide, which caused cancer among daughters of the treated women. Methods: The study was an exploratory qualitative facility-based conducted at Mwananyamala Regional Hospital in Kinondoni District, Dar-es-Salaam Region, Tanzania, among pregnant women who were enrolled in a clinical trial: “Adverse birth outcomes among mothers who received intermittent preventive treatment with Sulphadoxine- Pyrimethamine in the low malaria transmission region”. Data were collected through in-depth interviews and analyzed by thematic analysis with the aid of NVivo computer software. Findings: Several push and pull factors such as saving of the life of the fetus and the mother; delivery complications; the desire to contribute to maternal-fetal science; societal benefits; incentives; advice from medical professionals; free or voluntary participation, and therapeutic misconception influenced pregnant women to voluntarily participate in non-therapeutic clinical researches. Conclusion: The study findings show that saving of the life of the fetus and the mother, delivery complications, desire to contribute to maternal-fetal science, advice from medical professionals, and incentives were core factors for pregnant women’s participation in non-therapeutic clinical researches in Tanzania. Fetal harms and therapeutic misconceptions decelerate pregnant women’s rate to participate in non-therapeutic clinical researches hence bioethical education is highly needed in this aspect.
ARTIFICIAL INTELLIGENCE AND THE NEW CHALLENGES FOR EU LEGISLATION
Authors: GÜNEŞ PESCHKE Seldağ , PESCHKE Lutz
Published: August 2022

Artificial Intelligence is one of the increasing topics of the last decade which is developed by the new technological changes. With the introduction of AI into our daily lives, discussions occurred on machine learning and the legal and ethical issues governing artificial intelligence. At that point, conflicting situations emerged regarding the use of AI technologies, especially data issues and bias. In 1995, European Data Protection Directive, EU Directive 95/46 was passed which regulated the processing of personal data within the borders of EU and provided data privacy and security standards for the individuals. The Directive was repealed on 25th May 2018 by General Data Protection Regulation (GDPR), which brings new concepts with more strict rules on the protection of personal data. Due to its legal nature, GDPR includes binding rules not only for EU countries but also for those who carry out all activities related to data processing inside EU. With the development of technology and depending on different IT techniques, data processing has changed and access to data became easier than ever. As a result of these technologies, the concepts of big data and artificial intelligence have been widely discussed and the development of new electronic devices and the implementation of more use of robots have brought some legal questions into practice. Recently, there are some new regulations that seem likely to enter into EU legislation in the next years, such as Artificial Intelligence Act, Data Govermance Act, Data Act, and European Health Data Space. There is uncertainty for the next years, about how new regulations will affect each other including GDPR. This paper aims to discuss artificial intelligence, including GDPR and the new legal developments in the EU legislation within the technological implementations.
PKM USAHA AIR SUSU KEDELAI UNTUK HOME INDUSTRY
Authors: Masdani Masdani , Ariyanto Ariyanto
Published: August 2022

Soy milk is obtained by grinding soybeans soaked in water. In producing soy milk, Mitra experienced problems because the equipment in the production process was still manual and very simple. So that the production time becomes long and has an impact on the lack of income due to the limited production equipment. The aim of this community service program is to assist household-scale soy milk producer partners in terms of improving the quantity and quality of soy milk products. The solution that we can do through this program is by providing and introducing a soy milk machine and explaining how to maintain the machine. Results or output targets achieved from community service for partners, namely partners have used soy milk production machines so that the quality and quantity of soy milk can increase. In addition, there is an increase in the number of customers and turnover of partners as well as an increase in understanding and skills of partners.
WORKSHOP UNTUK PEMUDA PUTUS SEKOLAH DI KELURAHAN LAMBUNG BUKIT KECAMATAN PAUH PADANG DALAM BIDANG PENGELASAN
Authors: Effiandi Nota , Mulyadi Mulyadi , Fardinal Fardinal , Bukhari Bukhari , Alfian Alfian , Nofriadi Nofriadi , Nur Ichlas , Yetri Yuli
Published: August 2022

SMAW 2F welding training has been carried out at the Politeknik Negeri Padang (PNP) for youth from the Lambung Bukit sub-district, Pauh sub-district, Padang city in order to carry out the Tri Dharma of Higher Education. The SMAW 2F welding workshop was supported by the head of the Community Empowerment Agency (BPM) and Kelurahan because the community had been waiting for this activity for a long time. High school graduates in Lambung Bukit sub-district who do not yet have adequate skills to be able to compete in filling employment opportunities. With current technological developments, especially in the field of information technology, Lambung Bukit sub-district has experienced extraordinary development, due to the assimilation between the natives and the newcomers. On the other hand, population growth must also be followed by an increase in living facilities. To harmonize the progress of the two fields with the capabilities of human resources, various training and skills are needed, one of which is skills training in the field of electric welding. SMAW 2F electric welding training is currently very much needed to fill the shortage of labor in the welding field. After it was agreed with Kelurahan the PNP service team held a 4-day training which was attended by 30 Lambung Bukit youths at the Padang State Polytechnic Mechanical Engineering workshop. The results obtained showed that Lambung Bukit youth were able to perform SMAW electric welding using the 2F method well according to recognized welding standards. With the results obtained, all training participants received a SMAW 2F welding certificate from the Politeknik Negeri Padang. The Lambung Bukit community hopes that this kind of training can be carried out continuously because many young people want to improve their competencies which can be a provision in opening entrepreneurship and filing available job opportunities.
The Restoration of the Roads of the Yeongho-nam Regions in the 19th Century and it’s Historical-Geographic Interpretation: Focused on “Kumsong Ilgi”
Authors:   The Korean Society of Culture and Convergence, Bae Sookhee
Published: August 2022

Once in the Joseon Dynasty, a local scholar called Lizhixuan went from Miryang to Naju to hold ancestral rites with clansmen, stopped by Jinju to see the places where his ancestors , and pay a visit to his aunt's tomb. By restoring the digital map of his travels, it became possible to have a detailed understanding of the transportation and geography of Yeonghonam. Most of the stores in Daedongyeojido are located in a sparsely populated area between the hills. However, in “Kumsong Ilgi”, it is confirmed from the origin of the name of the stores that most of them were located in villages, at small ports for ferries, near bridges, and markets, etc. After the wars, the focus was placed on defense facilities and the general public’s interest in castles was heightened. The Yeongho-nam area was particularly attacked by Wakou, so the locations of mountain fortresses were recorded. Through Kumsong Ilgi it was possible to examine the way of thinking centered on family or tribe, especially along paternal lines.
A Study on Vocal Education in Applied Music Analysis of Research Trends in Korea.
Authors:   The Korean Society of Culture and Convergence, Hwang Eunji
Published: August 2022

The purpose of this study is to present the direction of future related research by analyzing domestic degree papers and papers related to vocal education published in academic journals. To this end, 175 papers (37 academic papers and 138 degree papers) that meet the conditions were collected and analyzed by year of publication, research method, research subject, and research content. The results of the study are as follows. First, vocal education research has shown a gradual increase since 2003 By 2018, it was found that the individual reached its peak. Second, as a result of analysis by research method, ‘literary research’ was found to have been conducted the most. Third, as a result of analysis by research subject, ‘literature and analysis theory’ was the highest. Fourth, as a result of analysis by research content, ‘case study’ was found to be the most common. Fifth, as a result of analyzing the trends by publishing journal, it was confirmed that the most studies were published in ‘popular music content’. Sixth, as a result of classification by registered information, the largest number of studies were published in the ‘registered place’. Based on the contents of the analysis results, the direction and direction of future related research were presented.
Development and Effectiveness of Life-span Career Designing Group Counseling Program for North Korean Immigrant Youth
Authors:   The Korean Society of Culture and Convergence, Shin Yunjeong , Ji Eun , Yoon Hyojung , Kim Jesun , Jun Jooram
Published: August 2022

The purpose of this study is to develop, to perform, and to explore the effects of life-span career designing group counseling program for North Korean immigrant youth. Development of life-span career designing group counseling program was conducted through three steps suggested by group counseling program development guidelines(Kim et al., 2011). Each session consisted of 120 minutes and four sessions were conducted. The effects of the program were verified through pretest and posttest by examining career decision-making self-efficacy(CDMSE), career adaptation, social responsibility. Interviews with participants were done at the end of each session and one month after. Findings showed that CDMSE and career adaptation were proved to improve, and participants showed their satisfaction with achievement of program goals. In addition, in regard to sustainable effects, participants answered personal change as the effectiveness of group, supporting and hindering factors to engaging, suggestions and limitations for future research were proposed.
Aspects of The Effects of Singlehood Reality Entertainment Use on Parasocial Relationships, Social Comparison and Life Satisfaction: Focused on Viewers’ Household Type Differences
Authors:   The Korean Society of Culture and Convergence, Dong Menglin , Na Eunkyung
Published: August 2022

This study explored the effects of singlehood reality program on parasocial interaction, life satisfaction and social comparison, and how these effects can differ across viewers’ household types. The survey analyses indicate that the viewership was significantly related with greater parasocial interaction, life satisfaction and greater social comparisons both upward and downward, whereas the difference between upward/downward comparisons was decreased. And the greater the viewership, the higher the comparative emotions (upward emotions as well as downward). Compared to the audiences of other types of households, single-household viewers showed higher parasocial interaction, but lower life satisfaction; greater social comparisons both upward and downward, and lower comparative emotions.
A Study on the Affinity of Kim Jong-sam’s Poetry and Film
Authors:   The Korean Society of Culture and Convergence, Yeo Jinsook
Published: August 2022

The purpose of this paper is to reveal the affinity between Kim Jong-sam’s poetry and film. Under the setting that the audiovisual image and rhetorical qualities that appear in Kim Jong-sam’s poems can be realized in movies, the interface between the two genres was examined. We focused on image presentation and rhetorical devices for films that are closely related to Kim Jong-sam’s poetry. This method is an inferred hypothesis that the artistic achievement of his poetry was specifically reproduced and expanded in a specific film. In a reality where the demand and value of visual aesthetics are increasing, the image operation of poetry expands the aesthetic framework and forms an axis of fusion art. Combining the poems of Kim Jong-sam, who preempted cinematic sensibility, with actual films is to promote fusion between genres. It is the discovery of a literary film that reads poetry in film. This is a work that finally confirms that Kim Jong-sam recognized himself as an ‘artist’, and is a poetic possibility that visual aesthetics can reproduce.
Delayed Choice and Quantum Causal Coherence
Authors: Wallner Gerold
Published: August 2022

Quantum information technology is one of the fastest crowing sectors within information technology. This paper is a conjecture about expected boundary conditions of nonlocal effects and shows the consequences of definite or indefinite causal order of entangled quantum events leading to causality. It focuses on nonlocal causality in relativistic systems, and introduces the notion of quantum causal coherence as a nonlocal property of relativistic causality, reflecting the relation of entanglement and the principle of least action. It is shown, that the principle of least action is the self-consistency mechanism of nonlocal causality in relativistic scenarios, especially in timelike scenarios of entangled quanta. From the view of relativistic scenarios, this paper examines the possibility of causal loops in quantum causal relations and investigates quantum causal relations in well established experiments.
Vibration Signal Analysis Based on Spherical Error Compensation
Authors: Wei Shan
Published: August 2022

A vibrating screen is important equipment in industrial production. According to the principle of bionics, a vibrating screen can be divided into a linear vibrating screen, elliptical vibrating screen, ball vibrating screen, and banana vibrating screen. There are also great problems with the use of a vibrating screen. The vibrating screen works due to the vibration excitation force generated by vibration. This work studies the motion trajectory of a vibrating screen by taking the vibrating screen with line motion trajectory as the research object. In this study, the vibration information is detected by an intelligent sensor, and the signal is filtered by an intelligent algorithm. Then, the spherical error compensation is used to improve the calculation accuracy, and the least square method is used to evaluate the error. Finally, the accurate vibration trajectory of the vibrating screen is obtained. The acquisition of a vibration track can provide the working efficiency and safety performance of the vibrating screen, and has social and economic benefits.
Real-time quantification of osteoclastic resorptive activity by electric cell-substrate impedance sensing
Authors: Jansen Ineke D.C. , van Velzen Thijs , de Vries Teun J. , Szulcek Robert , van Loon Jack J. W. A.
Published: August 2022

In several diseases, bone resorption by osteoclasts is dysregulated. Thus far, no simple technique for real-time measurement of resorption is available. Here, we introduce an impedimetric bioassay for real-time monitoring of resorption by making use of the electrical insulating properties of the resorbable substrate calcium phosphate. Different chemical stimuli were applied to (pre)osteoclasts cultured on a layer of calcium phosphate in multi-well plates containing electrodes. By this, osteoclast activity can be measured continuously over days, and the effects of stimulating or inhibiting factors can be quantified. When cells were cultured in the presence of an inflammatory factor such as IL-1β, the resorptive activity started earlier. The measured decline in resistance was higher at culture day 5 than at cultures with M-CSF or M-CSF + RANKL (M-CSF norm. Resistance = 1, M-CSF + RANKL = 0.7, M-CSF + RANKL + IL-1β = 0.5). However, at day 11, this difference had nearly disappeared. Likewise, bisphosphonates were shown to inhibit osteoclastic activity. Our findings illustrate the importance of real-time monitoring; wherefore, this method has high potential not only for the study of osteoclast resorptive activity in the context of osteoclast function and diseases but also could find application in high-throughput drug-testing studies.
Role of endometrial microRNAs in repeated implantation failure (mini-review)
Authors: Goharitaban Sepide , Abedelahi Ali , Hamdi Kobra , Khazaei Mozafar , Esmaeilivand Masoumeh , Niknafs Behrooz
Published: August 2022

MicroRNAs (miRNAs) play various roles in the implantation and pregnancy process. Abnormal regulation of miRNAs leads to reproductive disorders such as repeated implantation failure (RIF). During the window of implantation, different miRNAs are released from the endometrium, which can potentially reflect the status of the endometrium for in vitro fertilization (IVF). The focus of this review is to determine whether endometrial miRNAs may be utilized as noninvasive biomarkers to predict the ability of endometrium to implant and provide live birth during IVF cycles. The levels of certain miRNAs in the endometrium have been linked to implantation potential and pregnancy outcomes in previous studies. Endometrial miRNAs could be employed as non-invasive biomarkers in the assisted reproductive technology (ART) cycle to determine the optimal time for implantation. Few human studies have evaluated the association between ART outcomes and endometrial miRNAs in RIF patients. This review may pave the way for more miRNA transcriptomic studies on human endometrium and introduce a specific miRNA profile as a multivariable prediction model for choosing the optimal time in the IVF cycle.
Recent advances in metal catalyst- and oxidant-free electrochemical C-H bond functionalization of nitrogen-containing heterocycles
Authors: Li Ya-Nan , Wang Bin , Huang Ye-Kai , Hu Jin-Song , Sun Jia-Nan
Published: August 2022

The C-H functionalization of nitrogen-containing heterocycles has emerged as a powerful strategy for the construction of carbon-carbon (C-C) and carbon-heteroatom (C-X) bonds. In order to achieve efficient and selective C-H functionalization, electrochemical synthesis has attracted increasing attention. Because electrochemical anodic oxidation is ideal for replacing chemical reagents in C-H functionalization reactions. This mini-review summarizes the current knowledge and recent advances since 2017 in the synthetic utility of electrochemical transformations for the C-H functionalization of nitrogen-containing heterocycles.
Transcriptome-module phenotype association study implicates extracellular vesicles biogenesis in Plasmodium falciparum artemisinin resistance
Authors: Tandoh Kwesi Z. , Hagan Oheneba C. , Wilson Michael D. , Quashie Neils B. , Duah-Quashie Nancy O.
Published: August 2022

Plasmodium falciparum malaria is still an important disease in sub-Saharan Africa (sSA). Great strides have been made in its control spear-headed by artemisinin (ART)-based combination therapies (ACTs). However, concerns about the imminent spread of ART-resistant (ARTr) malaria parasites to sSA threaten gains already made. Attempts to mitigate this risk have highlighted the need to discover novel P. falciparum drug targets. Therefore, studies to deepen our understanding of the biology of P. falciparum are needed. The role of extracellular vesicles (EVs) in the biology of malaria parasites is not fully understood. Recently, the ART resistance-associated transcriptional profile has been reported to involve several biological processes connected to vesicular trafficking, proteotoxic stress, erythrocyte remodelling, and mitochondrial metabolism. We explored a role for EVs in developing the P. falciparum ARTr phenotype using bulk RNA sequencing of unsynchronized parasite cultures under untreated, 0.1% dimethyl sulfoxide and 700nM dihydroartemisinin treated conditions for six hours. As pathway and gene ontology analysis is limited in its curated knowledge repertoire on EVs biogenesis in P. falciparum, we used a modular (gene set) analysis approach to explore whether an EVs biogenesis module is associated with the ARTr phenotype in P. falciparum. We first generated well-defined EVs modules of interest and used statistical tools to determine differences in their expression among the parasite and treatment conditions. Then we used gene set enrichment analysis to determine the strength of the association between each EVs module of interest and the ARTr phenotype. This transcriptome-module phenotype association study (TMPAS) represents a well-powered approach to making meaningful discoveries out of bulk gene expression data. We identified four EVs module of interest and report that one module representing gene sets with correlated expression to PF3D7_1441800 – involved with EVs biogenesis in P. falciparum - is associated with the ARTr phenotype (R539T_DHA_treated versus R539T_untreated: normalized enrichment score (NES) = 1.1830174, FDR q-value < 0.25; C580R_DHA_treated versus C580R_untreated: NES = 1.2457103, FDR q-value < 0.25). PF3D7_1441800 has been reported to reduce EVs production when knocked out in P. falciparum. Altogether, our findings suggest a role for EVs in developing ART resistance and warrant further studies interrogating this association.
Prognostic significance of resting cardiac power to left ventricular mass and E/e’ ratio in heart failure with preserved ejection fraction
Authors: Chen Cong , Zhao Jie , Xue Ruicong , Liu Xiao , Zhu Wengen , Ye Min
Published: August 2022

Background

Cardiac power-to-left ventricular mass (power/mass) is an index reflecting the muscular hydraulic pump capability of the heart, and the E/e’ ratio is a specific indicator for identifying increased left ventricular filling pressure. Limited data exist regarding the prognostic value of incorporating power/mass and E/e’ ratio in heart failure with preserved ejection fraction (HFpEF).

Materials and methods

In total, 475 patients with HFpEF from the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist (TOPCAT) trial with complete baseline echocardiography data were included in our analysis. Patients were categorized into four groups according to power/mass and E/e’ ratio. The risk of outcomes was examined using Cox proportional hazards models and competing risk models.

Results

Patients with low power/mass and high E/e’ were more likely to be males (60.5%), with higher waist circumference, and had a higher prevalence of diabetes (52.1%), atrial fibrillation (50.4%), and lower estimated glomerular filtration rate (eGFR). Combined resting power/mass and E/e’ have graded correlations with left ventricular (LV) dysfunction and clinical outcomes in patients with HFpEF. After multivariable adjustments, an integrative approach combining power/mass and E/e’ remained to be a powerful prognostic predictor, with the highest HRs of clinical outcomes observed in patients with low power/mass and high E/e’ (all-cause mortality: HR 3.45; 95% CI: 1.69–7.05; P = 0.001; hospitalization for heart failure: HR 3.27; 95% CI: 1.60–6.67; P = 0.001; and primary endpoint: HR 3.07; 95% CI: 1.73–5.42; P < 0.001).

Conclusion

In patients with HFpEF, an echo-derived integrated approach incorporating resting power/mass and E/e’ ratio remained to be a powerful prognosis predictor and may be useful to risk-stratify patients with this heterogeneous syndrome.

Clinical Trial Registration

[https://clinicaltrials.gov], identifier [NCT00094302].
Toward data lakes as central building blocks for data management and analysis
Authors: Wieder Philipp , Nolte Hendrik
Published: August 2022

Data lakes are a fundamental building block for many industrial data analysis solutions and becoming increasingly popular in research. Often associated with big data use cases, data lakes are, for example, used as central data management systems of research institutions or as the core entity of machine learning pipelines. The basic underlying idea of retaining data in its native format within a data lake facilitates a large range of use cases and improves data reusability, especially when compared to the schema-on-write approach applied in data warehouses, where data is transformed prior to the actual storage to fit a predefined schema. Storing such massive amounts of raw data, however, has its very own challenges, spanning from the general data modeling, and indexing for concise querying to the integration of suitable and scalable compute capabilities. In this contribution, influential papers of the last decade have been selected to provide a comprehensive overview of developments and obtained results. The papers are analyzed with regard to the applicability of their input to data lakes that serve as central data management systems of research institutions. To achieve this, contributions to data lake architectures, metadata models, data provenance, workflow support, and FAIR principles are investigated. Last, but not least, these capabilities are mapped onto the requirements of two common research personae to identify open challenges. With that, potential research topics are determined, which have to be tackled toward the applicability of data lakes as central building blocks for research data management.
A GIS-based multi-hazard assessment at the San Pedro volcano, Central Andes, northern Chile
Authors: Alcozer-Vargas Nicolás , Reyes-Hardy María-Paz , Esquivel Alfredo , Aguilera Felipe
Published: August 2022

Recent advances in the modeling of volcanic phenomena have allowed scientists to better understand the stochastic behavior of volcanic systems. Eruptions can produce various types of volcanic phenomena of different sizes. The size of a given volcanic phenomenon dominates its spatial distribution and is commonly represented by volume/mass parameters in the models that reproduce their behavior. Multi-hazard assessments depend on first-order parameters to forecast hazards at a given geographic location. However, few multi-hazard assessments consider the size of the eruption (e.g., tephra fallout) to co-parameterize the size of the accompanying phenomena (e.g., mass flows) in a given eruptive scenario. Furthermore, few studies simulate multi-phenomenon eruptive scenarios with semi-continuous variations in their size, something that allows a better quantification of the aleatoric variability of the system. Here, we present a multi-hazard assessment of the San Pedro volcano, a high-threat volcano from northern Chile, that produced two large-size Plinian eruptions (VEI 5 and 6) in the last 16 ka, and ten Strombolian eruptions (VEI 2) between 1870 and 2021 CE, with the latest occurring on 2 December 1960 CE. We use intra-scenarios (i.e., subdivisions of eruptive scenarios) to explore the size variability of explosive volcanic phenomena. The size of intra-scenarios is extrapolated from the largest-size deposits of each type of phenomenon from the geologic record of the San Pedro volcano. We simulate explosive intra-scenarios for tephra fallout, concentrated PDCs, and lahars, and effusive scenarios for blocky lava flows. On the local scale, mass flows are likely (66–100%) to affect transport and energy infrastructure within a 14 km radius of the volcano. On the regional scale, large-size eruptions (VEI 5) in the rainy season are about as likely as not (33–66%) to accumulate 1 cm of tephra on energy, transport, and mining infrastructure over a 50 km radius, and these same eruptions are unlikely (10–33%) to accumulate 1 cm of tephra on the city of Calama. This work shows how multi-phenomenon intra-scenarios can be applied to better quantify the aleatoric variability of the type and size of volcanic phenomena in hazard assessments.
Redating the Zhuwobu Paleolithic site in the Huailai basin, North China, using the MET-pIRIR procedure on K-feldspars
Authors: GUO Yujie , XIAN Qi , LU Chun , NIU Dongwei
Published: August 2022

As part of the “generalized Nihewan Basin”, the Huailai basin has recently attracted archaeologists’ attention. Ten Paleolithic sites were found in this basin in 2014; among these, the Zhuwobu site is the oldest―dated to 504 ± 76 ka using the electron spin resonance (ESR) dating method. This study redated the Zhuwobu site using the multiple elevated temperatures (MET) post infrared (pIR) infrared stimulated luminescence (IRSL) procedure (MET-pIRIR) on both multi-grained single and multiple aliquots of potassium-rich feldspars (K-feldspars). The consistency of the Deresults obtained from the single- and multiple-aliquot procedures mutually supported the reliability of our age results. Our results suggest that the cultural layer at this site was deposited about 280 ± 13 ka (MIS 8) ago, ∼220 ka younger than the previous ESR age. Considering the region’s tectonic history and the characteristics of the sedimentary facies for the ZWB site, we suggested that the previous ESR age results for the bottom three samples from the sediment profile might be overestimated due to poor bleaching before burial. In contrast, the ESR age of 346 ± 32 ka (MIS 10) for one cultural-layer collected sample might be more reliable due to higher-quality bleaching before burial. Further archaeological, geological, and chronological studies are needed to explore the ancient hominins’ survival conditions in the “generalized Nihewan Basin” and possible connections with the renowned Zhoukoudian sites.
Endocrine disrupting chemicals interfere with decidualization of human primary endometrial stromal cells in vitro
Authors: Lavogina Darja , Visser Nadja , Samuel Külli , Davey Eva , Björvang Richelle D. , Hassan Jasmin , Koponen Jani , Rantakokko Panu , Kiviranta Hannu , Rinken Ago , Olovsson Matts , Salumets Andres , Damdimopoulou Pauliina
Published: August 2022

Multiple studies have shown associations between exposure to endocrine disrupting chemicals (EDCs) and reduced fertility in women. However, little is known about the target organs of chemical disruption of female fertility. Here, we focus on the hormone-sensitive uterine lining, the endometrium, as a potential target. Decidualization is the morphological and functional change that endometrial stromal cells undergo to support endometrial receptivity, which is crucial for successful implantation, placentation, and pregnancy. We investigated the effect of nine selected EDCs on primary human endometrial stromal cell decidualization in vitro. The cells were exposed to a decidualization-inducing mixture in the presence or absence of 1 μM of nine different EDCs for nine days. Extent of decidualization was assessed by measuring the activity of cAMP dependent protein kinase, Rho-associated coiled-coil containing protein kinase, and protein kinase B in lysates using photoluminescent probes, and secretion of prolactin into the media by using ELISA. Decidualization-inducing mixture upregulated activity of protein kinases and prolactin secretion in cells derived from all women. Of the tested chemicals, dichlorodiphenyldichloroethylene (p,p’-DDE), hexachlorobenzene (HCB) and perfluorooctanesulfonic acid (PFOS) significantly reduced decidualization as judged by the kinase markers and prolactin secretion. In addition, bisphenol A (BPA) reduced prolactin secretion but did not significantly affect activity of the kinases. None of the EDCs was cytotoxic, based on the assessment of total protein content or activity of the viability marker casein kinase 2 in lysates. These results indicate that EDCs commonly present in the blood circulation of reproductive-aged women can reduce decidualization of human endometrial stromal cells in vitro. Future studies should focus on detailed hazard assessment to define possible risks of EDC exposure to endometrial dysfunction and implantation failure in women.