bluuebunny/crossref_metadata_2025 huggingface dataset:
Mesenchymal Stem Cell-derived Exosomes Rescue Oxygen-Glucose Deprivation-induced Injury in Endothelial Cells
Authors: Kong Li-yun , Liang Meng-ya , Liu Jian-ping , Lai Ping , Ye Jun-song , Zhang Zu-xiong , Du Zhi-ming , Yu Jun-jian , Gu Liang , Xie Fa-chun , Tang Zhi-xian , Liu Zi-you
Published: February 2020

Objective:

The effects of mesenchymal stem cell (MSC)-derived exosomes on brain microvascular
endothelial cells under oxygen-glucose deprivation (OGD), which mimic cells in deep
hypothermic circulatory arrest (DHCA) in vitro, are yet to be studied.

Methods:

MSCs were co-cultured with primary rat brain endothelial cells, which were then exposed
to OGD. Cell viability, apoptosis, the inflammatory factors (IL-1β, IL-6, and TNF-α), and
the activation of inflammation-associated TLR4-mediated pyroptosis and the NF-κB signaling
pathway were determined. Furthermore, exosomes derived from MSCs were isolated and incubated
with endothelial cells to investigate whether the effect of MSCs is associated with MSCderived
exosomes. Apoptosis, cell viability, and the inflammatory response were also analyzed in
OGD-induced endothelial cells incubated with MSC-derived exosomes.

Results:

OGD treatment promoted endothelial cell apoptosis, induced the release of inflammatory
factors IL-1β, IL-6, and TNF-α, and inhibited cell viability. Western blot analysis showed that
OGD treatment-induced TLR4, and NF-κB p65 subunit phosphorylation and caspase-1 upregulation,
while co-culture with MSCs could reduce the effect of OGD treatment on endothelial cells.
As expected, the effect of MSC-derived exosomes on OGD-treated endothelial cells was similar to
that of MSCs. MSC-derived exosomes alleviated the OGD-induced decrease in the viability of
endothelial cells, and increased levels of apoptosis, inflammatory factors, and the activation of inflammatory
and inflammatory focal pathways.

Conclusion:

Both MSCs and MSC-derived exosomes attenuated OGD-induced rat primary brain
endothelial cell injury. These findings suggest that MSC-derived exosomes mediate at least some
of the protective effects of MSCs on endothelial cells.
Ointment Formulation and Characterization of Arum Manis Mango (Mangifera indica L.) Leaves’ Methanol Extract as an Antibacterial Agent Against Propionibacterium acnes
Authors: Ningsih Dian R. , Zusfahair Zusfahair , Hermawan Dadan , Anggraeni Wulan , Aboul-Enein Hassan Y.
Published: February 2020

Background:

Acne is caused by several factors, including the active secretion of sebaceous
sweat glands, hyperkeratosis in the hair infundibulum and the effects of bacteria. One plant
which has the potential as an antibacterial agent is the extract of Arum Manis mango leaves.

Methods:

The Minimum Inhibitory Concentration (MIC) of methanol extract of mango leaves was
determined, which can inhibit Propionibacterium acnes activity. The antibacterial activity tests
were performed using agar diffusion. The ointment formulation, the characteristics of ointment preparations,
and the ointment activity against P. Acnes are discussed.

Results:

MIC of methanol extract of mango leaves value is 5 ppm with an inhibition zone of 1 mm.
The ointment obtained is white, has a distinctive smell, semisolid form, possesses a pH of 4.92 -
5.87, dispersive power of 5.05 - 6.30 cm, and adhesive power of 1 - 3.67 seconds, homogeneous
and protective. Ointment preparations of methanol extract of mango leaves have activity on P.
acnes on the 0 and 15th day of storage. The activities of ointment preparation on day 0 with concentrations
of 0, 5, 10 and 15 ppm are 0.00 mm; 10.20 mm; 19.97 mm and 23.60 mm respectively,
while the inhibition zones produced by the preparation of ointment on day 15 with concentrations
of 0, 5, 10 and 15 ppm are 0.00 mm; 5.71 mm; 9.58 mm and 21.88 mm respectively.

Conclusion:

Methanol extract of mango leaves (Mangifera indica L.) and ointment preparation
can inhibit the growth of Propionibacterium acnes.
Is it Necessary to Calculate Young’s Modulus in AFM Nanoindentation Experiments Regarding Biological Samples?
Authors: Kontomaris Stylianos-Vasileios , Malamou Anna , Stylianou Andreas
Published: February 2020

Background:

The determination of the mechanical properties of biological samples using
Atomic Force Microscopy (AFM) at the nanoscale is usually performed using basic models arising
from the contact mechanics theory. In particular, the Hertz model is the most frequently used theoretical
tool for data processing. However, the Hertz model requires several assumptions, such as homogeneous
and isotropic samples and indenters with perfectly spherical or conical shapes. As it is widely
known, none of these requirements are 100 % fulfilled for the case of indentation experiments at the
nanoscale. As a result, significant errors arise in the Young’s modulus calculation. At the same time,
an analytical model that could account complexities of soft biomaterials, such as nonlinear behavior,
anisotropy, and heterogeneity, may be far-reaching. In addition, this hypothetical model would be ‘too
difficult’ to be applied in real clinical activities since it would require a very heavy workload and
highly specialized personnel.

Objective:

In this paper a simple solution is provided to the aforementioned dead-end. A new approach is introduced in order to provide a simple and accurate method for the mechanical characterization at the nanoscale.

Method:

The ratio of the work done by the indenter on the sample of interest to the work done by the
indenter on a reference sample is introduced as a new physical quantity that does not require homogeneous,
isotropic samples or perfect indenters.

Results:

The proposed approach, not only provides an accurate solution from a physical perspective but also a simpler solution which does not require activities such as the determination of the cantilever’s spring constant and the dimensions of the AFM tip.

Conclusion:

It has been observed from this opinion paper that the solution aims to provide a significant
opportunity to overcome the existing limitations provided by Hertzian mechanics and apply AFM
techniques in real clinical activities.
PENGARUH CORPORATE GOVERNANCE PADA KEPATUHAN PENGUNGKAPAN TRANSAKSI BERELASI BERDASARKAN PERNYATAAN STANDAR AKUNTANSI KEUANGAN (PSAK) NO. 7 TAHUN 2015.
Authors: Hasna Pratista Ardhana Reswari
Published: February 2020

Abstrak : Pengaruh Corporate Governance Pada Kepatuhan Pengungkapan Transaksi Berelasi Berdasarkan Pernyataan Standar Akuntansi Keuangan (Psak) No. 7 Tahun 2015. Penelitian ini bertujuan untuk mengetahui pengaruh corporate governance terdahap kepatuhan pengungkapan transaksi pihak berelasi. Variabel independen dalam penelitian ini adalah komite audit, kepemilikan institusional, kepemilikan manajemen, dan komisaris independen.  Variabel dependen dalam penelitian ini adalah kepatuhan pengungkapan transaksi pihak berelasi. Jenis penelitian ini merupakan penelitian kuantitatif  dengan menggunakan data sekunder berupa laporan keuangan tahunan dari perusahaan sektor utama selama tahun 2015 sampai 2016 yang didapat dari Bursa Efek Indonesia. Teknik pengambilan sampel yang digunakan adalah purposive sampling dan sebanyak 21 perusahaan memenuhi kriteria kelengkapan data akhirnya 42 laporan keuangan tahunan yang dipakai dalam penelitian ini. Metode statistika yang digunakan adalah regresi panel. Dari analisis yang dilakukan komite audit, kepemilikan manajemen, dan komisaris independen berpengaruh secara positif signifikan terhadap pengungkapan transaksi pihak berelasi, sementara kepemilikan institusi tidak berpengaruh secara positif terhadap pengungkapan transaksi pihak berelasi. Kata kunci: corporate governance, pengungkapan, transaksi pihak berelasi
PENGARUH KEWAJIBAN MORAL DAN LINGKUNGAN SOSIAL TERHADAP KEPATUHAN WAJIB PAJAK ORANG PRIBADI PENGUSAHA
Authors: Nabila Zahra Durah , Isroah Isroah
Published: February 2020

Abstrak : Pengaruh Kewajiban Moral Dan Lingkungan Sosial Terhadap Kepatuhan Wajib Pajak Orang Pribadi Pengusaha. Penelitian ini bertujuan untuk mengetahui (1) Pengaruh  Kewajiban Moral terhadap Kepatuhan Wajib Pajak. (2) Pengaruh Lingkungan Sosial terhadap Kepatuhan Wajib Pajak. (3) Pengaruh Kewajiban Moral dan Lingkungan Sosial terhadap Kepatuhan Wajib Pajak. Populasi dalam penelitian ini adalah Wajib Pajak Orang Pribadi Pengusaha di KPP Pratama Bantul sebanyak 19.398 Wajib Pajak dengan sampel sebanyak 200 Wajib Pajak. Data Penelitian ini diperoleh melalui kuesioner. dengan teknik pengambilan sampel insidental sampling. Hasil penelitian ini menunjukan (1) Kewajiban Moral berpengaruh positif dan signifikan terhadap Kepatuhan Wajib Pajak dengan nilai koefisien determinasi 0,734 (2) Lingkungan sosial berpengaruh positif dan signifikan terhadap Kepatuhan Wajib Pajak dengan koefisien determinasi 0,830 (3) Kewajiban moral dan Lingkungan Sosial berpengaruh positif dan signifikan terhadap Kepatuhan Wajib Pajak dengan nilai koefisien regresi 0,682 dan 0,306 nilai Fhitung lebih besar dibandingkan dengan Ftabel pada tingkat signifikansi 5% (179,323 3,04).Kata kunci: Kepatuhan Wajib Pajak, Kewajiban Moral, Lingkungan Sosial
PENGARUH PEMAHAMAN KODE ETIK PROFESI AKUNTAN DAN KECERDASAN MAHASISWA TERHADAP PERILAKU ETIS MAHASISWA AKUNTANSI UNIVERSITAS NEGERI DI YOGYAKARTA
Authors: Musyadad Nur Anwar , Sagoro Endra Murti
Published: February 2020

Abstrak : Pengaruh Pemahaman Kode Etik Profesi Akuntan Dan Kecerdasan Mahasiswa Terhadap Perilaku Etis Mahasiswa Akuntansi Universitas Negeri Di Yogyakarta. Penelitian ini bertujuan untuk mengetahui pengaruh Pemahaman Kode Etik Profesi Akuntan dan Kecerdasan Mahasiswa terhadap Perilaku Etis Mahasiswa Akuntansi Universitas Negeri di Yogyakarta. Jenis penelitian ini adalah kuantitatif. Populasi pada penelitian ini yaitu mahasiswa S1 Akuntansi pada tiga Perguruan Tinggi Negeri di Yogyakarta. Sampel dalam penelitian ini sebesar 273 diambil dengan metode proportionate random sampling. Teknik pengambilan data yang digunakan dalam penelitian ini adalah kuesioner yang telah diuji validitas dan reliabilitasnya. Teknik analisis data yang digunakan adalah analisis regresi sederhana dan analisis regresi berganda yang didahului dengan uji normalitas, uji multikolinieritas serta uji heteroskedastisitas. Hasil penelitian ini menunjukkan bahwa (1) Pemahaman Kode Etik Profesi akuntan berpengaruh positif signifikan terhadap Perilaku Etis mahasiswa; (2) Kecerdasan Intelektual berpengaruh positif signifikan terhadap Perilaku Etis mahasiswa;  (3) Kecerdasan Emosional berpengaruh positif signifikan terhadap Perilaku Etis mahasiswa; (4) Kecerdasan Spiritual berpengaruh positif signifikan terhadap Perilaku Etis mahasiswa; (5) Pemahaman Kode Etik Profesi akuntan, Kecerdasan Intelektual, Kecerdasan Emosional, dan Kecerdasan Spiritual secara simultan berpengaruh positif signifikan terhadap Perilaku Etis mahasiswa. Kata Kunci: Kode Etik Profesi Akuntan, Kecerdasan Intelektual, Kecerdasan Emosional, Kecerdasan Spiritual, Perilaku Etis.
Feasibility of Real Time Internet-Based Teleconsultation in Patients With Multiple Sclerosis: Interventional Pilot Study (Preprint)
Authors: D'Haeseleer Miguel , Eelen Piet , Sadeghi Nima , D'Hooghe Marie B , Van Schependom Jeroen , Nagels Guy
Published: February 2020

BACKGROUND

Telemedicine (TM) is currently flourishing in rural and emergency settings, but its implementation in the routine management of chronic neurological disorders has developed with more hesitation. Limited access to specialized care facilities and expanding patient populations, combined with unprecedented mobility restrictions imposed by the coronavirus disease pandemic, are currently stressing the need for remote solutions in this field. Studies in patients with multiple sclerosis (MS) have been heterogeneous in objectives and methodology but generally support the concept that TM interventions produce clinical benefits, cost-effectiveness, and user satisfaction. Nonetheless, data on live interaction between patients and health care providers for MS teleconsultation purposes remain scarce.

OBJECTIVE

The aim of this study is to demonstrate the feasibility of planned real time audiovisual teleconsultation over the internet for patients with MS.

METHODS

A total of 20 patients with MS presenting at a specialized MS center in Belgium were recruited for this study. One teleconsultation was scheduled for each participant. Patients were provided a unique hyperlink by mail in advance, leading them automatically and directly to the virtual waiting room, where they could accept or decline our incoming call. All teleconsultations were performed by a trained medical student with the intention to keep the conversation similar to what is usually discussed during a classic face-to-face MS consultation; no remote physical exams were performed. The approach was considered feasible if at least 80% of the planned TM visits could be successfully completed at the foreseen moment. Patient satisfaction (technical quality, convenience, and overall quality of care) was evaluated at the end of each teleconsultation by means of 5-point Likert scales containing the categories very unsatisfied, unsatisfied, neutral, satisfied, and highly satisfied.

RESULTS

Out of 20 consultations, 17 were successfully completed (85%). Failures were due to patients not responding (n=2) and technical issues (n=1). Out of the 17 consultations, 17 patients declared themselves satisfied or highly satisfied for technical quality, 15 patients for convenience, and 16 patients for overall quality of care.

CONCLUSIONS

Planned real time audiovisual teleconsultation over the internet is feasible and highly appreciated in patients with MS. Incorporation of such services in routine clinical MS practice is expected to improve access to specialized care facilities for affected patients.
Evaluation of More Stamina, a Mobile App for Fatigue Management in Persons with Multiple Sclerosis: Protocol for a Feasibility, Acceptability, and Usability Study (Preprint)
Authors: Giunti Guido , Rivera-Romero Octavio , Kool Jan , Bansi Jens , Sevillano Jose Luis , Granja-Dominguez Anabel , Izquierdo-Ayuso Guillermo , Giunta Diego
Published: February 2020

BACKGROUND

Multiple sclerosis (MS) is one of the world’s most common neurologic disorders leading to severe disability in young adults. MS-related fatigue directly impacts on the quality of life and activity levels of people with MS. Self-management strategies are used to support them in the care of their health. Mobile health (mHealth) solutions can offer tools to help symptom management. Following a user-centered design and evidence-based process, an mHealth solution called More Stamina was created to help persons with MS manage their fatigue.

OBJECTIVE

The overall study aims are to explore the feasibility, acceptability, and usability of More Stamina, a mobile app for fatigue self-management for persons with MS.

METHODS

A mixed-methods, multicenter study will be used to assess the feasibility, acceptability, and usability of More Stamina. The study will take place during the third and fourth quarters of 2020 (Q3-Q4 2020) in 3 locations: Argentina, Spain, and Switzerland. A longitudinal cohort study will take place, and think-aloud protocols, open-ended interviews, and short answer questionnaires will be used. Persons with MS will be recruited from the different locations. This study seeks to enroll at least 20 patients that meet the criteria from each site for the longitudinal cohort study (total n=60).

RESULTS

Ethical approval has been granted in Argentina and is pending in Spain and Switzerland. Outcomes will be published in peer-reviewed medical journals and presented at international conferences.

CONCLUSIONS

Findings from this study will be used to help understand the role that mHealth can play in fatigue management in MS.

CLINICALTRIAL

ClinicalTrials.gov NCT04244214; https://clinicaltrials.gov/ct2/show/NCT04244214

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/18196
Quantum SDP-Solvers: Better upper and lower bounds
Authors: van Apeldoorn Joran , Gilyén András , Gribling Sander , de Wolf Ronald
Published: February 2020

Brandão and Svore \cite{brandao2016QSDPSpeedup} recently gave quantum algorithms for approximately solving semidefinite programs, which in some regimes are faster than the best-possible classical algorithms in terms of the dimension n of the problem and the number m of constraints, but worse in terms of various other parameters. In this paper we improve their algorithms in several ways, getting better dependence on those other parameters. To this end we develop new techniques for quantum algorithms, for instance a general way to efficiently implement smooth functions of sparse Hamiltonians, and a generalized minimum-finding procedure.We also show limits on this approach to quantum SDP-solvers, for instance for combinatorial optimization problems that have a lot of symmetry. Finally, we prove some general lower bounds showing that in the worst case, the complexity of every quantum LP-solver (and hence also SDP-solver) has to scale linearly with mn when m≈n, which is the same as classical.
A INFLUÊNCIA DA GESTÃO DO CONHECIMENTO NA MOTIVAÇÃO EMPREENDEDORA DE PROFISSIONAIS DA ÁREA DE TECNOLOGIA DA INFORMAÇÃO
Authors: Neves Isabela Dias , Amarante Juliana Marangoni , Martins Menegassi Cláudia Herrero
Published: February 2020

No século XXI o conhecimento passou a ser considerado recurso integrante dos fatores de produção de todos os tipos de organização. Sua gestão, primeiramente de cunho funcionalista, passou a significar ganhos não somente para as organizações, mas para as pessoas que nelas trabalham. A falta dessa gestão, todavia, principalmente em empresas da área de tecnologia, pode causar descontentamento no trabalho e, inclusive, a busca por outra atividade na qual seja possível aplicar uma Gestão do Conhecimento adequada, tão necessária na área de Tecnologia da Informação. Diante desse contexto, a presente pesquisa teve como objetivo compreender a influência da Gestão do Conhecimento na motivação empreendedora de profissionais da área de Tecnologia da Informação na cidade de Maringá – PR. Os resultados demonstraram que a motivação para o empreendedorismo na área de Tecnologia da Informação por pessoas que trabalhavam previamente em empresas dessa mesma área, teve influência expressiva do descontentamento com a forma como era conduzida – ou não conduzida – a Gestão do Conhecimento nessas empresas, fazendo com que os entrevistados optassem por abrir negócios próprios na área, onde pudessem ser protagonistas dos processos típicos da Gestão do Conhecimento.
ANÁLISE ESTATÍSTICA DO GERENCIAMENTO E REAPROVEITAMENTO DE RESÍDUOS DA CONSTRUÇÃO CIVIL
Authors: De Souza Sampaio Nilo Antonio , Werneck Caio Silva Werneck Silva , Abraão Ricardo Pereira , Martins Letícia Duarte , Rangel do Nascimento João Vitor , Hygino Adrízia Cordeiro , Nunes de Souza Ywan Yago
Published: February 2020

A expansão urbana e o celebre adensamento das cidades de médio e grande porte, tem provocado inúmeras dificuldades para destinação do grande volume de resíduos gerados pelas atividades privadas de construção, reformas e demolição de edificações, além daquelas obras públicas de construção e adequação estruturais, levando os administradores municipais a buscarem soluções mais eficazes para gestão do problema.Os resíduos de concreto apresentam grande potencial para serem reciclados comparados com outros resíduos, entretanto, o número de estudos realizados no Brasil é muito pequeno dificultando a utilização deste material em dosagens estruturais. Em virtude disso, desenvolve-se um estudo teórico-experimental visando minimizar o impacto causado ao meio ambiente e caracterizar as propriedades do agregado e do concreto reciclado; no estudo teórico exploram-se aspectos realizados à geração, deposição, processos para recuperação, britagem, casos práticos, pesquisas envolvendo reciclados de concreto e as recomendações normativas existentes. No desenvolvimento experimental, analisou-se a influência do período decorrido entre a moldagem e a reciclagem nas propriedades dos agregados e concretos. Os resultados indicam que resíduos reciclados após a sua geração, contribuem positivamente para as propriedades mecânicas do concreto, devido à existência de grande quantidade de partículas não-hidratadas de cimento, tais concretos obtiveram resultados superiores para resistência à compressão e tração quando comparados aos concretos com agregados naturais.Assim, o objetivo desta pesquisa é estudar a viabilidade da reutilização do agregado reciclado de concreto e misto, através da análise de resultados de ensaios laboratoriais, com base em uma pesquisa de substituição gradativa do agregado miúdo, visando também que em razão das suas propriedades físicas e mecânicas de concreto, o RCC é adequado para substituir os agregados naturais de concreto. Resultado que nos faz considerar esse material como uma alternativa viável em concretos estruturais, bases de pavimentações e artefatos de concreto podem ser adotados pelo município de Resende e outros, o que vai ao encontro da resolução nº 307/2002 do conselho Nacional do Meio Ambiente (CONAMA). Palavras Chave: Resíduos de Construção e Demolição, Agregados Reciclados de Concreto e Meio Ambiente.
Perilaku Berbagi Pengetahuan dan Budaya Tim pada Kinerja Inovasi Pelayanan
Authors: Irhamna Nadia
Published: February 2020

ABSTRACT
This study aims to find out the direct influence of knowledge sharing behaviorand the team culture on the service innovation performance. This research uses three variables that are knowledge sharing behavior as an independent variable, team culture as a intervening variable and service innovation performance as a dependent variable. The research uses primary data that is processed using SPSS software. Population in this research is employees of PT. Pos Indonesia branch offices Surakarta, with criteria that have been determined by researchers. The measurements in this questionnaire use a scale of 1 up to 10 intervals and this study used a total of 80 respondents. The result of research indicates that: 1) Knowledge sharing behavior has a significant effect on team culture, 2) Knowledge sharing behavior has a significant effect on service innovation performance, 3) team culture has a significant effect on service innovation performance.
Keyword: service innovation performance, knowledge sharing behaviour, team culture.
Corporate Social Responsibility Disclosure, Profitabilitas dan Harga Saham Tiga Sektor BUMN yang terdaftar di BEI
Authors: Firizqi Nur Kamiliyah
Published: February 2020

Penelitian ini bertujuan untuk menguji pengaruh Corporate Social Responsibility Disclosure terhadap Profitabilitas dan Harga saham pada tiga sektor BUMN yaitu pertambangan, konstruksi, pembangunan dan gas yang terdaftar di Bursa Efek Indonesia tahun 2014-2017. Hasil menunjukkan bahwa Corporate Social Responsibility Disclosure (CSRD) berpengaruh terhadap Harga saham dan Profitabilitas. Sedangkan Profitabilitas tidak berpengaruh terhadap Harga saha, namun profitabilitas dapat menjadi variabel intervening hubungan antara Corporate Social Responsibility Disclosure (CSRD) terhadap Harga saham.
Therapeutic Inertia in Pediatric Diabetes: Challenges to and Strategies for Overcoming Acceptance of the Status Quo
Authors: Corathers Sarah D. , DeSalvo Daniel J.
Published: February 2020

Despite significant advances in therapies for pediatric type 1 diabetes, achievement of glycemic targets remains elusive, and management remains burdensome for patients and their families. This article identifies common challenges in diabetes management at the patient-provider and health care system levels and proposes practical approaches to overcoming therapeutic inertia to enhance health outcomes for youth with type 1 diabetes.
Diabetes, Therapeutic Inertia, and Patients’ Medication Experience
Authors: Bzowyckyj Andrew S. , Begert John E.
Published: February 2020

Factors contributing to therapeutic inertia related to patients’ medication experiences include concerns about side effects and out-of-pocket costs, stigmatization for having diabetes, confusion about frequent changes in evidence-based guidelines, low health literacy, and social determinants of health. A variety of solutions to this multifactorial problem may be necessary, including integrating pharmacists into interprofessional care teams, using medication refill synchronization programs, maximizing time with patients to discuss fears and concerns, being cognizant of language used to discuss diabetes-related topics, and avoiding stigmatizing patients. Managing diabetes successfully is a team effort, and the full commitment of all team members (including patients) is required to achieve desired outcomes through an individualized approach.
Yüksek Plastisiteli Killerde Rezidüel Kayma Direncinin Direkt Kesme Deneyi Sonuçları Kullanılarak Tayin Edilmesi
Authors: AKIŞ Ebru
Published: February 2020

Heyelanlar
doğal afet sayılarının afet türlerine göre dağılımı dikkate alındığında %45 ile
en sık karşılaşılan doğa olaylarıdır. Heyelan çözüm projelerinin yapılabilmesi
için heyelan sırasında kayma düzleminde oluşan rezidüel kayma dayanımı
parametrelerinin gerçeğe en yakın şekilde tahmin edilmesi gerekir. Söz konusu
parametreler, tekrarlı direkt kesme ve halka kesme deneyleri yapılarak tayin
edilebildiği gibi, geri analiz ya da zeminin fiziksel özellikleri yardımıyla
literatürdeki korelasyonlar kullanılarak da öngörülebilmektedir. Kayma dayanımı
parametreleri geri analiz yöntemi kullanılarak tayin edilirken, yeraltı suyu
durumunun rezidüel kayma dayanımı değerlerini direkt olarak etkilediği
bilinmektedir. Ayrıca, heyelan sırasındaki yeraltı suyu durumunun gerçeğe yakın
olarak öngörülmesinin zorluğu aşikârdır. Öte yandan, literatürden elde edilen rezidüel
kayma dayanımı parametreleri oldukça geniş bir aralıkta sonuçlar verebilmektedir.
Tüm bunların yanı sıra, halka kesme deneyleri laboratuvarlarda yaygın olarak
yapılmamakta, yaygın olarak yapılan tekrarlı direkt kesme deneylerinin ise
zemin cinsine bağlı olarak çok düşük hızlarda yapılması gerekebilmektedir. Bu
sebeple, deney süresi deneylerin pratikte kullanımını olumsuz yönde
etkilemektedir. Yukarıda belirtilen kısıtlamaların çerçevesinde bu çalışmada
normal konsolide ve yüksek plastisiteli killerde pik ve rezidüel kayma direnci
açıları arasındaki ilişki incelenmiştir. Araştırmanın ilk kısmında ülkemiz
literatüründeki çalışmaların sonuçları değerlendirilerek, kalıcı kayma direnci
ile zemin indeks ve pik kayma direnci arasında ampirik bağıntılar
öngörülmüştür. Daha sonra, örselenmiş yüksek plastisiteli kil numunelerle
yapılan tekrarlı direkt kesme deneyleri yapılmış, elde edilen sonuçlar ile önerilen
bağıntılar karşılaştırılmıştır.
ВЛИЯНИЕ ЛИЧНОСТНОГО РАЗВИТИЯ РОДИТЕЛЕЙ НА СОЦИАЛЬНУЮ АДАПТАЦИЮ ДЕТЕЙ С ОГРАНИЧЕННЫМИ ВОЗМОЖНОСТЯМИ ЗДОРОВЬЯ
Authors: Markova Svetlana
Published: February 2020

За последние 10 лет в России произошли социально-экономические, политические трансформации, обуславливающие изменения, связанные с отношением общества к детям с ограниченными возможностями здоровья. Исследователи указывают на недостатки социальной адаптации детей этой категории, связанные как со спецификой нравственного развития общества, так и личностным развитием их родителей. Исследование потребности родителей в самоактуализации осуществлялось посредством самоактуализационного теста Э. Шострома, методики Е. Е. Рукавишниковой. Изучение личностного развития детей с ограниченными возможностями здоровья проводили с помощью теста-опросника А. Я. Варга и В. В. Столина, методики «Лесенка» (В. Г. Щур) и др. Доказано влияние личностного развития родителей на социальную адаптацию детей с ограниченными возможностями здоровья. Рассмотрены теоретические подходы к проблеме личностного развития родителей детей с ограниченными возможностями здоровья. Сделан вывод, что эффективность социальной адаптации этой категории детей определяется культурным и ценностным отношением родителей. Полученные результаты могут быть применены специалистами для организации психолого-педагогического сопровождения личностного развития родителей детей с ограниченными возможностями развития в условиях образовательных учреждений.

For the last ten years socio-economic and political changes have taken place in Russia, causing changes in the aspect of attitude towards children with disabilities. Researchers specify on the defects of social adaptation of the children of this category, related both to the specifics of moral development of society, and the lacks of personality development of their parents. The study of the parents’ need for self-actualization was carried out through the selfactualization test of E. Shostrom. The study of personal development of children with disabilities was carried out using the technique of E. E. Rukavishnikova, test questionnaire of A. Ya. Varga and V. V. Stolin, the technique of “Ladder” (V. G. Shchur) and others. The influence of personal maturity of parents on the effectiveness of socialization of children with disabilities is proved. Theoretical approaches to the problem of personality development of parents of children with disabilities are considered. It is concluded that the effectiveness of social adaptation of this category of children is determined by the level of personality development of parents, causing a change of options of parents in the perception of a child and the organization of co-operating with them. As a result of the study, conclusions were drawn about the relationship between the level of development of the personality of parents and the successful social adaptation of children with developmental disabilities. The results can be applied by specialists to organize psychological and pedagogical support of the personal development of parents of children with disabilities in educational institutions.
ОБ ОТДЕЛЬНЫХ ПРИНЦИПАХ И ПРИЕМАХ ОБУЧЕНИЯ РУССКОМУ ЯЗЫКУ КАК ИНОСТРАННОМУ (НА ПРИМЕРЕ ИЗУЧЕНИЯ ИДИОМ, ОТРАЖАЮЩИХ ПОЛИТИЧЕСКУЮ ПРОБЛЕМАТИКУ)
Authors: Hua Wang
Published: February 2020

Рассматриваются принципы и приемы обучения русскому языку как иностранному в китайской студенческой аудитории, основанные на включении в процесс обучения иностранному языку материала, ориентированного на будущую профессиональную сферу (идиоматические выражения, отражающие политическую проблематику). На основе теоретического обобщения подходов китайских и российских лингвистов сформулированы основные подходы к выделению идиоматических выражений со стороны содержания (теоретическое исследование, исследование употребления) и со стороны методологии и лексикографии. Представлена характеристика ведущих методических принципов реализации языкового образования для китайских студентов: описаны приемы семантизации слов, способы лексикографической работы, описана логика работы в условиях специально организованной учебно-коммуникативной ситуации на всех этапах, представлен анализ работы с профессиональными текстами. Описаны механизмы учебной работы с идиоматическими выражениями, направленные на развитие совокупности иноязычной компетентности студентов китайских вузов. Экспериментальная апробация представленной совокупности приемов обучения русскому языку как иностранному в аудитории китайских студентов на продвинутом уровне показала свою эффективность.

The article considers the principles and methods of teaching Russian as a foreign language in the Chinese student audience, based on the inclusion in the process of teaching a foreign language of material focused on the future professional sphere (idiomatic expressions reflecting political issues). On the basis of the theoretical generalization of the approaches of Chinese and Russian linguists, the main approaches to the allocation of idiomatic expressions from the content (theoretical research, use research) and from the methodology and lexicography are formulated. The characteristic of the leading methodological principles of the implementation of language education for Chinese students is presented: the methods of semantization of words, methods of lexicographic work are described, the logic of work in a specially organized educational and communicative situation at all stages is described, the analysis of work with professional texts is presented. The mechanisms of educational work with idiomatic expressions aimed at the development of the set of foreign language competence of students of Chinese universities are described. Experimental approbation of the presented set of methods of teaching Russian as a foreign language in the audience of Chinese students at an advanced level has shown its effectiveness.
Критика теории спроса и предложения
Authors: Ситников Антон
Published: February 2020

В статье дается критика варианта теории спроса и предложения, изложенного в одном из самых популярных в американских университетах учебнике по экономиксу К. Макконнелла и С. Брю. Проводится анализ понятий спроса, предложения и так называемых законов спроса и предложения. Показывается место и действительное значение этих «законов», а также предлагаются новые дефиниции этих величин.
Evolution of Different Bacterial Mningoencephalitis: Series of Case Presentations and Literature Review
Authors: Claudia Cambrea Simona , Consuela Marcas , Simona Diaconu , Raluca Mihai , Daniela Pinzaru Anca , Florin Mangu , Larisia Mihai
Published: February 2020

Bacterial meningitis is one of the most important medical emergencies, a life-threatening condition that leads to death in all the cases in untreated patients. In infants and young children, especially under 5 years old, the most encountered and severe forms are caused by Streptococcus pneumoniae, Neisseria meningitidis and Hemophilus influenzae type b. The risk of neurological impairment after an acute episode of bacterial meningitis is relatively high. Worldwide, prevention through vaccination decreased dramatically incidence and mortality related to these disease. In Romania vaccination for Neisseria meningitides is optional available for just 6 months, vaccination for Streptococcus pneumoniae by one year, and for Haemophylus influenzae type B is available over 10 years.

We present evolution of a series of three cases with different bacterial meningoencephalitis with severe evolution and prolonged hospitalization. All these cases were reported in unvaccinated children for germs that cause meningitis.
”In Memory of the Snow Queen” – Hans Christian Andersen Recalled and Retold
Authors: Zańko Aldona
Published: February 2020

The main focus of the present paper is the so-called “intertextual revision”, explored as one of the most recent and innovative strategies employed while reviving the legacy of the Danish fairy-tale classic Hans Christian Andersen. In order to illustrate this practice, I discuss a short story entitled Travels with the Snow Queen (2001), by an American writer Kelly Link, which is a reworking of Andersen's worldfamous fairy tale The Snow Queen (1844). Link’s take on Andersen’s tale represents one of the leading directions within revisionary fairy-tale fiction, inspired by feminism and gender criticism. The analysis is centered around the narrative strategies employed by the author in order to challenge the gender logic incorporated into Andersen’s account, as well as the broader fairy-tale tradition it belongs to.
Perspectives of the development of world economy in the blockchain conditions and Big Data
Authors: Anghelache Constantin , Anghel Mădălina-Gabriela , Dumbravă Gabriel Ștefan , Dumitru Daniel
Published: February 2020

Blockchain is a concept that tends to revolutionize the world of finance in a technological leap that allows fast, secure and decentralized transactions. The Blockchain technology is used in virtual coins (bitcoin) conditions, with a high innovation potential, applicable in various areas, with the advantage of storing databases, resulting in an unprecedented level of transparency in the private or public area. Interestingly, under the bitcoin conditions, the black chain system uses a decentralized peer-to-peer payment system. Practically, the bitcoin can be considered as the most appropriate triple game accounting system. All of these considerations are developing in the big data era, which is defined as a large, diverse, high-volume information base requiring new forms of processing. Big data is important for businesses because based on these, strategic and marketing decisions can be made to optimize the activity in the market conditions and consumer preferences. European Union directives provide for measures to ensure the development of all states and, in this context, the community. At the same time, some measures provide for a more accelerated development for states with a low accession. For this, funds have been made from which important amounts are allocated to these states. The complex development of the European Union aims, in fact, to improve the quality of life (standard of living) in all Member States. At the European community level there are databases usable in economic analyzes. Also, Eurostat is the institution with the most complex databases. Recently, the Conference of the Directors of the Institute of Statistics in the European States analyzed the perspective of calculating the indicators in the context of the big data to be implemented. The article focuses on the concrete study of the use of large data in the calculation of the indicators that underlie the comparability between the EU Member States.
The Emigration and Influence Factors in Romania
Authors: Enache Andreea-Oana
Published: February 2020

The economic and social transition affected the population and the demographic phenomena in all the ex-communist countries. Immigration can be considered as a potential solution to the problem of population aging. But here too, it must be born in mind that immigrants may not properly adapt to the new labor market they have entered, if they come from very different cultures. Almost all the countries that have migrants, offer residence permits only to those who bring highly qualified workforce, while the legal possibilities of immigration of the unskilled workers are diminishing. Therefore, the demographic perspectives are not the most optimistic. The forecasts developed by specialists reveal dramatic future developments for the population of Romania. The factors that can cause a person to migrate are of several types. In this study it will be shown that migration is the result of several individual actions of analysis, people evaluating both the benefits and the risks involved by a possible migration.
Big 4 and audit fees in the context of adopting International Financial Reporting Standards
Authors: Tache Marta
Published: February 2020

The main purpose of this article is to determine the impact that Big 4 companies have had after the adoption of IFRS became mandatory and if the level of the fees related to the audit services registered a significant increase. Thus, after a thorough research of the specialized studies, we analyzed the impact of financial reporting according to the International Financial Reporting Standards, determining how the audit fees were influenced and which was the impact of the largest companies targeted in this study. In order to determine the number of companies audited by Big 4, we analyzed all the companies listed on Bucharest Stock Exchange, during the period 2010-2018, which trade premium shares. It is obvious that the financial reporting according to the International Financial Reporting Standards increases the number of companies audited by Big 4, although there has audit fees with higher values. In the following, we will analyze the changes that have occurred in the audit market of Romania.
Strategies and perspectives reffered to the analysis and development of the preuniversity education system from Romania
Authors: Țoţan Lavinia-Ștefania , Frăsineanu Corina
Published: February 2020

The paper presents the actual state of the preuniversity education system from Romania, provided, also, solutions and strategies for its development. It describes also the evolution of the preuniversity education system between 2000 and 2018 and also the impact of the european funds in increase of quality for the preuniversity education system. There are realised also prognosis for indicators between 2020 and 2022.
Is conventionally calculated anchor-based minimum clinically important difference value catches the real clinical increment? Determining the situations that make the answer “no” by a simulation study
Authors: Yüksel Selcen , Demir Pervin , Alkan Afra
Published: February 2020

The aim of this study was to examine the accuracy of conventionally used method-optimal cutoff of Receiver Operating Characteristic (ROC) curve- to determine the minimum clinically important difference (MCID), which is the estimator of responsiveness for scales, by a simulation study. The baseline person parameters were firstly generated and, by using these values, two gold standard groups were constructed as “improved” and “non-improved” after the treatment. Five point-likert response patterns were obtained for 20 items in each group, representing pre- and post-treatment responses of individuals. The mean change score between post treatment and baseline scores for the improved group was considered as real MCID (MCIDR), after baseline and post-treatment total scores were calculated from response patterns. The cut-off for change score specified by ROC analysis, which best discriminates between improved group and not improved group, MCIDROC, was compared to MCIDR. The scenarios of simulation were consisted of sample size and distribution of total scores for improved group. The data were generated for each of 40 scenarios with 1000 MCMC repeats. It was observed that the MCIDR and MCIDROC were not so affected by sample size. However, MCIDROC overestimated the MCIDR values in all scenarios. Briefly, the cut-off points obtained by ROC analysis found to be greater than the real MCID values. Therefore, alternative methods are required to calculate MCID.
Impact of Intravenous Fluids and Enteral Nutrition on the Severity of Gastrointestinal Dysfunction: A Systematic Review and Meta-analysis
Authors: Asrani Varsha M. , Brown Annabelle , Bissett Ian , Windsor John A.
Published: February 2020

Introduction

Gastrointestinal dysfunction (GDF) is one of the primary causes of morbidity and mortality in critically ill patients. Intensive care interventions, such as intravenous fluids and enteral feeding, can exacerbate GDF. There exists a paucity of high-quality literature on the interaction between these two modalities (intravenous fluids and enteral feeding) as a combined therapy on its impact on GDF.

Aim

To review the impact of intravenous fluids and enteral nutrition individually on determinants of gut function and implications in clinical practice.

Methods

Randomized controlled trials on intravenous fluids and enteral feeding on GDF were identified by a comprehensive database search of MEDLINE and EMBASE. Extraction of data was conducted for study characteristics, provision of fluids or feeding in both groups and quality of studies was assessed using the Cochrane criteria. A random-effects model was applied to estimate the impact of these interventions across the spectrum of GDF severity.

Results

Restricted/ goal-directed intravenous fluid therapy is likely to reduce ‘mild’ GDF such as vomiting (p = 0.03) compared to a standard/ liberal intravenous fluid regime. Enterally fed patients experienced increased episodes of vomiting (p = <0.01) but were less likely to develop an anastomotic leak (p = 0.03) and peritonitis (p = 0.03) compared to parenterally fed patients. Vomiting (p = <0.01) and anastomotic leak (p = 0.04) were significantly lower in the early enteral feeding group.

Conclusions

There is less emphasis on the combined approach of intravenous fluid resuscitation and enteral feeding in critically ill patients. Conservative fluid resuscitation and aggressive enteral feeding are presumably key factors contributing to severe life-threatening GDF. Future trials should evaluate the impact of cross-interaction between conservative and aggressive modes of these two interventions on the severity of GDF.
Analytical Study Based on Perspectives of Teacher Educators in India with Respect to Education for Sustainable Development
Authors: Jetly Manisha , Singh Nandita
Published: February 2020

Education for sustainable development (ESD) has been accepted worldwide as one of the most powerful paradigms of thinking, which has a potential for changing the ongoing course of unsustainable development in order to save the fate of life on Mother Earth. As we prepare ourselves to achieve the 17 sustainable development goals (SDGs) of United Nations 2030 Agenda, it is crucial to analyze and reflect on the initiatives taken, which aim at sensitizing the stakeholders of education with the holistic concept of ESD, especially when it has been reported in the literature that countries of the Asia Pacific region have been slow in formally embracing the concept of ESD in their education system. With this contextual background, the present research paper aimed at understanding the prevailing perception of ESD amongst the teacher educators of India. A qualitative deductive content analysis methodology was adopted for an in-depth analysis of the subjective responses of teacher educators, teaching graduate and post-graduate level courses of teacher education programs of India’s Chandigarh region. A codebook was developed on the basis of UNESCO’s Teaching and Learning for a Sustainable Future (TLSF) program for the analysis. The findings of the research identified how and to what extent the indicators of ESD were addressed through broader categories of knowledge, skills and values. The research joins larger conversation of reorienting the teacher education programs particularly through the lens of cultural sustainability to achieve a sustainable future.
Determination of corticosterone from rat hair samples by HPLC-MS method
Authors: Elek Ferencz , Ferenc Boda , Zsolt Gáll , Melinda Kolcsár , Gabriella Donáth-Nagy , Szende Vancea
Published: February 2020

Corticosterone is an adrenocortical steroid hormone with glucocorticoid and mineralocorticoid effects. Based on previous studies, the plasma level of corticosterone correlates with the stress exposure of rodents. Because the half-life of corticosterone in blood is short, its plasma concentration can be used as an acute stress marker. But hair is accumulating the systemic and locally produced corticosterone, therefore it can be used to study chronic stress. However, the accurate quantification of corticosterone is an analytical challenge owing to the very low amount of hormone found in a complicated biological matrix. The high performance liquid chromatography coupled with mass spectrometry (HPLC-MS) can provide the required selectivity and sensitivity for this purpose. Currently published methods for corticosterone quantification involve complicated sample preparation and long run time. Accordingly, the aims of the study were to simplify the extraction method of the corticosterone from rat hair samples and to develop an optimized HPLC-MS method for the accurate quantification. The rat hair samples were washed with methanol, dried and cut, then extracted with methanol at room temperature for 24 hours. The lipids were precipitated with formic acid aqueous solution and eliminated by centrifugation. The corticosterone was separated from other compounds with reverse phase chromatography using acetonitrile and 0,1% aqueous solution of formic acid as mobile phase. The detection was performed in positive SIM mode measuring the 347 m/z molecular ion. A six point calibration was performed in the range of 0,5-20 ng/ml, the accuracy was tested with quality control samples at two different concentration level. The total run time is only 4,2 minutes and the lower limit of quantification (LLOQ) is 0,5 ng/ml, with 10 pg absolute sensitivity. By determining the quantity of the hormone for a well-defined hair region, based on the speed of hair growth, we can characterize the retrospective stress exposure of the animals in different conditions.