bluuebunny/crossref_metadata_2025 huggingface dataset:
The death and die process for nursing team of intensive therapy center
Authors: Seiffert Carla Suellen Lisboa Carneiro , Freitas Karina de Oliveira , Monteiro Gleidiane Oliveira , Vasconcelos Esleane Vilela
Published: July 2020

Objetivo: Descrever as percepções da equipe de enfermagem do Centro de Terapia Intensiva sobre o processo de morte e morrer e suas implicações para o cuidado de enfermagem. Métodos: Pesquisa descritiva com abordagem qualitativa, realizada com nove técnicos de enfermagem e seis enfermeiros da terapia intensiva, no período de 03 a 31 de outubro de 2016. Resultados: Os depoimentos foram consolidados em três unidades temáticas: “O Centro de Terapia Intensiva e o processo de morte e morrer”, “Repercussão do processo de morte e morrer para o cuidado de enfermagem” e “Sentimentos dos profissionais de enfermagem perante a morte no centro de terapia intensiva”. Conclusão: Através desta, foi possível discorrer sobre as percepções dos profissionais de enfermagem sobre o processo de morte e morrer e evidenciar que apesar do surgimento de sentimentos negativos perante a morte, não houve grandes repercussões na prestação do cuidado por eles oferecido.
Preventive care for asthma and multidisciplinary team social work: art and education experience
Authors: Silva Angela Maria Caulyt Santos da
Published: July 2020

Objective: The purpose of this article is to describe the experience in art education of Social Work in a multiprofessional team, in the preventive care for asthma, and the changes felt by the participants of the "Choir Voices in Overcoming", through the (inter) experiences and experiences of singing and living with asthma. Methods: Qualitative, empirical, bibliographical and phenomenological research. Using field diary, semi-structured interview and content analysis. A total of 14 women and a man between the ages of 23 and 75 participated in the Asthma Reference Center. Results: Art education, through music, is a resource for the social worker to enhance the self-esteem of people in asthma treatment. Conclusion: People with asthma socializing while engaged in art education, influences their quality of life.
Care for carriers of mental disorder in primary care: an interdisciplinary and multiprofessional practice
Authors: Almeida Danielle Rodrigues , Soares Jessica Nayara Caires , Dias Marcilia Gonçalves , Rocha Fernanda Cardoso , Neto Gregório Ribeiro de Andrade , Andrade Dina Luciana Batista
Published: July 2020

Objetivo: Conhecer como é realizado o cuidado ao Portador de Transtorno Mental (PTM) nas Estratégias de Saúde da Família, verificando se os profissionais estão seguros da sua atuação. Metodologia: Trata-se de um estudo qualitativo, embasado na análise do discurso, realizado nas Estratégias da Saúde da Família de uma cidade da região norte de Minas Gerais; a coleta de dados realizou-se através de um roteiro de entrevista semi estruturada. Resultados: Percebe-se que os profissionais se sentem inseguros para atuarem nessa área de concentração sendo levantados como dificultadores a deficiência na teoria científica e a desarticulação da rede, porém contraditório a esses surge uma nova expectativa: “o matriciamento” uma ferramenta implantada como apoio para a assistência que vem se tornando a principal arma para um cuidado mais holístico. Conclusão: Há necessidade de reverter os défices na construção teórica cientifica dos profissionais da enfermagem assim como promover sua educação permanente.
Experiences of elderly people who participate in social groups
Authors: Guerra Sabrina da silva , Aguiar Aline Cristiane de Sousa Azevedo , Santos Ester da Silva , Martins Lucas Amaral
Published: July 2020

Objetivo: apreender experiências de pessoas idosas que participam de centros de convivência. Métodos: estudo descritivo, exploratório de abordagem qualitativa realizado com doze pessoas idosas que frequentam grupos de convivência em um município no interior da Bahia. A coleta dos dados foi realizada por meio de entrevista semiestruturada, dezembro de 2017 a fevereiro de 2018. Os dados foram analisados e interpretados conforme a análise de conteúdo temática proposta por Laurence Bardin. Resultados: após a análise emergiram seis categorias: melhoria na condição de saúde; evitar a solidão, fonte de suporte social; apoio e incentivo familiar; atividades aquáticas e dança. Conclusão: O estudo mostrou que a participação de pessoas idosas em grupos de convivência se mostra necessária, devido melhorias na qualidade de vida, na autoestima, na construção de vínculos e apoio social, no qual auxilia-as em todo o processo de envelhecimento.
Quality of life of elderly people who practice physical activities
Authors: Almeida Barbara Lopes , Souza Maria Eduarda Borém Fernandes , Rocha Fernanda Cardoso , Fernandes Tatiana Froes , Evangelista Christiane Borges , Ribeiro Karine Suene Mendes Almeida
Published: July 2020

Objetivo: Avaliar a qualidade de vida dos idosos e pessoas em envelhecimento. Metodologia: Amostra foi composta por 37 idosos em envelhecimento. Foi aplicado um pré- teste (MEEM). Os critérios de inclusão e exclusão foram para a obtenção da amostra final, obtida a partir da aplicação do questionário WHOQOL – OLD. Foram analisados através do programa EXCEL 2010. Resultados: O estudo mostrou que a prática da atividade física com idosos teve o intuito de uma QV melhor, observando-se que a prevalência é do sexo feminino. Conclusão: Este estudo pode ajudar na elaboração de ações em saúde, a partir da melhor compreensão das questões que influenciam a qualidade de vida dos idosos, devido à diminuição da autoestima.
Worldview of young schoolchildren from a municipality in the state of Piauí-bra
Authors: Castro Antonia de Maria Rodrigues de Sousa , Silva Maria Adelane Monteiro da , Parente José Reginaldo Feijão
Published: July 2020

Objetivo: Conhecer a visão de mundo que os jovens escolares de um município da região nordeste do Piauí – BRA têm sobre sua realidade. Método: Qualitativo, exploratório, realizado entre abril a setembro de 2016, com 10 mães e 10 adolescentes entre 12 e 15 anos, do sexto ano do Ensino Fundamental. A coleta de dados, foi entrevista semiestruturada, visita domiciliaria e observação livre no intervalo das aulas, na análise os mapas e árvore de associação de ideias de Spink. Resultados: Necessitam de espaços e lazer como brincar, andar de bicicleta e jogar futebol. Sentem a ausência dos pais; muitos não residem na mesma casa ou trabalham o dia inteiro. Vimos a escola como espaço de socialização, porem, não oferece atividades para tal. Conclusão: A necessidade de lazer, de brincar, de espaço para essas atividades, assim como também a ausência dos pais, foram evidenciados e interferem na promoção da saúde dos adolescentes.
Mortality due to external causes in the state of Rondônia: time series analysis from 1999 to 2015
Authors: Pereira Priscilla Perez da Silva , Moreira kátia Fernanda Alves , Figueiredo Ana Cláudia Morais Godoy , Araújo Laís Xavier de
Published: July 2020

Objetivo: Descrever a mortalidade por causas externas no Estado de Rondônia no período de 1999 e 2015. Método: Estudo de série temporal utilizando dados da Declaração de Óbito disponibilizados pela Agência de Vigilância em Saúde do Estado de Rondônia. Para a análise de tendência realizou-se regressão linear utilizando o pacote estatístico Stata®11. Resultados: Foram registrados no Estado de Rondônia 111.651 óbitos sendo 22,2% classificados como causas externas. O coeficiente médio de óbitos por esta causa no período foi 89,7 por 100.000 habitantes e desvio padrão de 6,5. A regressão linear apresentou um aumento anual nos óbitos por acidentes de trânsito de 2,1%, os óbitos por agressões tiveram um decréscimo anual de 1,98%, suicídios e outras causas externas permaneceram estacionárias. Conclusão: Os resultados evidenciaram a necessidade de fortalecimento das ações preventivas entre homens jovens e políticas públicas para redução de acidentes de trânsito no estado de Rondônia.
Influence of maternal age in perinatal conditions in live births of São Luís, Maranhão
Authors: Nunes Flávia Baluz Bezerra de Farias , Silva Polyana Cabral da , Barbosa Thays Luanny Santos Machado , Lopes Maria Lucia Holanda , Silva Elza Lima da
Published: July 2020

Este trabalho tem por objetivo investigar os fatores maternos e perinatais associados aos extremos da idade reprodutiva da mulher em São Luís, Maranhão. Trata-se de um estudo transversal e analítico, realizado em São Luís/MA com população de 16.474 mães. Os dados foram coletados no SINASC disponibilizado pela Secretaria Municipal de Saúde de São Luís/MA. Na análise de dados utilizou-se o Teste Qui-quadrado de Pearson e calculou-se a Odds Ratio com nível de significância de α = 0.05. Verificou-se que as adolescentes apresentaram maior chance de nascimento prematuros (OR=1,37; p<0,001); mulheres com idade avançada apresentaram maior risco para baixo peso ao nascer (OR=1,22; p=0,022). Tanto as adolescentes (OR=2,09; p<0,001) quanto as mães com idade avançada (OR=1,85; p<0,001) possuem chances aumentadas para realizarem menos que seis consultas de pré-natal. Os resultados perinatais, nascimento prematuro, baixo peso ao nascer e a realização de menos de seis consultas pré-natais, são elevados nas gestações de adolescentes e mulheres em idade avançada.
Publicity
Authors: Kelly Erin I.
Published: July 2020

Publicity refers to an aspect of the moral demand that political arrangements be justified to their subjects. Political justification should be public in the following ways: it should be transparent, it should represent common knowledge, and it should be grounded in shared values. So understood, publicity is a condition of the legitimacy of political authority and the justice of political institutions. Justice and legitimacy are aspects of the morality of institutions.
Epistemic Injustice
Authors: Medina José
Published: July 2020

This entry covers the literature on epistemic injustice, offering a brief overview of the key concepts, highlighting the central normative issues in the ethics of knowing, and reviewing the central positions that authors have taken on issues of individual and collective responsibility for epistemic injustice.
Leaking
Authors: Guelke John
Published: July 2020

Leaking is deliberately exposing confidential information, while also attempting to keep one's responsibility for the act anonymous. To count as an instance of leaking, the agent must also have access to the information in question due to some position of trust. In the early twenty‐first century, leaking has been most prominent and morally controversial due to two famous cases exposing aspects of US security policy: Edward Snowden's exposure of the National Security Agency's mass surveillance program, and Chelsea Manning's exposure of US conduct of the second Iraq war. This entry discusses (a) what leaking is, (b) when it is justified, and (c) the ethics of keeping responsibility for an act of exposure anonymous. The entry considers the cases of Snowden and Manning alongside more typical acts of leaking as part of day‐to‐day politics.
Objectification
Authors: Stock Kathleen
Published: July 2020

This entry considers the question “What is objectification?” After preliminary remarks about different methodological approaches, several possible answers, or groups of answers, are introduced, separated out in terms of broad themes. Each is situated in relation to historical and more contemporary authors. These themes are: objectification as instrumentalization; objectification as reduction to the body; objectification as negation of subjectivity or agency; objectification as naturalization. Objectification is considered in relation to both sexual and racial contexts. Finally, these themes are discussed in relation to the wider category of “mind suppression,” and its relation to objectification in the familiar context of imagery.
Lithium Accommodation in a Redox‐Active Covalent Triazine Framework for High Areal Capacity and Fast‐Charging Lithium‐Ion Batteries
Authors: Buyukcakir Onur , Ryu Jaegeon , Joo Se Hun , Kang Jieun , Yuksel Recep , Lee Jiyun , Jiang Yi , Choi Sungho , Lee Sun Hwa , Kwak Sang Kyu , Park Soojin , Ruoff Rodney S.
Published: July 2020

The synthesis of a new type of redox‐active covalent triazine framework (rCTF) material, which is promising as an anode for Li‐ion batteries, is reported. After activation, it has a capacity up to ≈1190 mAh g−1 at 0.5C with a current density of 300 mA g−1 and a high cycling stability of over 1000 discharge/charge cycles with a stable Coulombic efficiency in an rCTF/Li half‐cell. This rCTF has a high rate performance, and at a charging rate of 20C with a current density of 12 A g−1 and it functions well for over 1000 discharge/charge cycles with a reversible capacity of over 500 mAh g−1. By electrochemical analysis and theoretical calculations, it is found that its lithium‐storage mechanism involves multi‐electron redox‐reactions at anthraquinone, triazine, and benzene rings by the accommodation of Li. The structural features and progressively increased structural disorder of the rCTF increase the kinetics of infiltration and significantly shortens the activation period, yielding fast‐charging Li‐ion half and full cells even at a high capacity loading.
Structural Changes of 2D FexMn1−xO2 Nanosheets for Low‐Temperature Growth of Carbon Nanotubes
Authors: Lim Joohyun , Jin Xiaoyan , Hwang Seong‐Ju , Scheu Christina
Published: July 2020

The synthesis of carbon nanotubes (CNTs) is usually done by metallic catalysts with a gaseous carbon precursor at high temperature. Yet, mild synthesis conditions can broaden the application of CNTs and their composites. In the present work, it is unraveled why partially substituted Fe ions in 2D MnO2 nanosheets lead to the growth of CNTs at low temperatures of 400−500 °C. The local formation of Fe3C by carbon precursor explains the unusually high catalytic activity of 2D FexMn1−xO2 nanosheets for preparing CNTs. Finally, Fe3C is oxidized to Fe3C/FeOx yolk/shell morphology in ambient atmosphere after the CNT formation reaction. These results shed light on the development of novel catalyst materials that allow for efficiently prepare CNTs under mild conditions for their wider use in energy‐harvesting applications.
Directly Grown Vertical Graphene Carpets as Janus Separators toward Stabilized Zn Metal Anodes
Authors: Li Chao , Sun Zhongti , Yang Tian , Yu Lianghao , Wei Nan , Tian Zhengnan , Cai Jingsheng , Lv Jiaze , Shao Yuanlong , Rümmeli Mark H. , Sun Jingyu , Liu Zhongfan
Published: July 2020

Zinc metal anode has garnered a great deal of scientific and technological interest. Nevertheless, major bottlenecks restricting its large‐scale utilization lie in the poor electrochemical stability and unsatisfactory cycling life. Herein, a Janus separator is developed via directly growing vertical graphene (VG) carpet on one side of commercial glass fiber separator throughout chemical vapor deposition. A simple air plasma treatment further renders the successful incorporation of oxygen and nitrogen heteroatoms on bare graphene. Thus‐derived 3D VG scaffold affording large surface area and porous structure can be viewed as a continuation of planar zinc anode. In turn, the Janus separator harvests homogenous electric field distribution and lowered local current density at the interface of the anode/electrolyte, as well as harnesses favorable zincophilic feature for building‐up uniform Zn ionic flux. Such a separator engineering enables an impressive rate and cycle performance (93% over 5000 cycles at 5 A g−1) for Zn‐ion hybrid capacitors and outstanding energy density (182 Wh kg−1) for V2O5//Zn batteries, respectively. This strategy with large scalability and cost‐effectiveness represents a universal route to protect prevailing metal anodes (Zn, Na, K) in rechargeable batteries.
High‐Resolution 3D Printed Photonic Waveguide Devices
Authors: Gao Hongwei , Chen George F. R. , Xing Peng , Choi Ju Won , Low Hong Yee , Tan Dawn T. H.
Published: July 2020

Photonic building blocks fabricated using two‐photon polymerization laser lithography are reported. 3D polymer structures are fabricated using a direct laser writing process with nonlinear two‐photon absorption in photosensitive material. The 3D photonic structures include 3D photonic waveguides, Bragg gratings, and resonators. In particular, high‐quality spiral and air‐bridge waveguides providing 3D light guiding beyond a single plane are demonstrated. Sub‐micrometer features as well as unique coupling interfaces with 1.6 dB coupling losses and large 3 dB bandwidth are also demonstrated. Experimental characterization reveals the good transmission performance of the fabricated photonic devices. In addition, the waveguides are demonstrated to support 30 Gb s−1 NRZ (nonreturn to zero) and 56 Gb s−1 PAM4 (pulse amplitude modulation 4) high‐speed data. Small power penalties of 0.7 dB for NRZ (BER = 10−12) and 1.5 dB for PAM4 (BER = 10−6) are obtained.
Targeting Soluble Epoxide Hydrolase with TPPU Alleviates Irradiation‐Induced Hyposalivation in Mice via Preventing Apoptosis and Microcirculation Disturbance
Authors: Zhang Yaoyang , Bai Yuwen , Bai Jie , Li Lijun , Gao Lu , Wang Fu
Published: July 2020

IR irradiation‐induced dysfunction of the salivary gland and hyposalivation are one of the main complications of radiotherapy treatment for malignant head and neck tumors, and its mechanisms are not fully understood. IR‐induced microcirculation disturbance and apoptosis is one of the most important mechanisms. Most recent studies have focused on the regenerative effects of epoxyeicosatrienoic acids (EETs) through the process of increased angiogenesis. This study suggests that increasing endogenous EETs by the soluble epoxide hydrolase (sEH) inhibitor TPPU can reverse dysfunctional salivary glands and hyposalivation by improving the associated microenvironment and tissue regeneration. The findings suggest that TPPU alleviates hyposalivation and histological lesions, increases angiogenesis and reduces apoptosis of acinar cells significantly in IR‐damaged mice. The results in vitro demonstrate that TPPU promotes the proliferation and inhibits apoptosis of human salivary gland (HSG) cells, and enhances the motility and angiogenesis of human umbilical vein endothelial cells (HUVECs). The results also suggest that TPPU‐induced synergy and crosstalk between acinar cells and vascular endothelial cells might contribute to angiogenesis. Together, this study proves the feasibility of targeting sEH using TPPU to promote angiogenesis and reduce apoptosis, and also indicates the potential of sEH inhibitors for functional reconstruction of IR‐induced salivary glands damage.
Demonstration of Wide Bandgap AlGaN/GaN Negative‐Capacitance High‐Electron‐Mobility Transistors (NC‐HEMTs) Using Barium Titanate Ferroelectric Gates
Authors: Chandrasekar Hareesh , Razzak Towhidur , Wang Caiyu , Reyes Zeltzin , Majumdar Kausik , Rajan Siddharth
Published: July 2020

A negative‐capacitance high electron mobility transistor (NC‐HEMT) with low hysteresis in the subthreshold region is demonstrated in the wide bandgap AlGaN/GaN material system using sputtered BaTiO3 as a “weak” ferroelectric gate in conjunction with a conventional SiNx dielectric. An enhancement in the capacitance for BaTiO3/SiNx gate stacks is observed in comparison to control structures with SiNx gate dielectrics directly indicating the negative capacitance contribution of the ferroelectric BaTiO3 layer. A significant reduction in the minimum subthreshold slope for the NC‐HEMTs is obtained in contrast to standard metal‐insulator‐semiconductor HEMTs with SiNx gate dielectrics—97.1 mV dec−1 versus 145.6 mV dec−1—with almost no hysteresis in the ID–VG transfer curves. These results are promising for the integration of ferroelectric perovskite oxides with III‐Nitride devices toward NC‐field‐effect transistor switches with reduced power consumption.
Interfacial Effects in Lithium and Sodium Batteries
Authors: Usiskin Robert , Maier Joachim
Published: July 2020

Modern batteries are composite systems that contain a high density of interfaces. Device performance is often determined by effects that emerge at interfaces. A survey of these phemonena is presented here. At essentially all interfaces, space charge layers are present that can modify the charge transport, transfer, and storage properties. Practical interfaces show additional complex phenomena, including passivation layer formation, current constriction, partial blocking of mobile species, and a variety of other effects. Some characteristic interfacial issues associated with the four mass storage modes are described and a few specific points that arise in solid state batteries are discussed.
DYNC1H1‐related disorders: A description of four new unrelated patients and a comprehensive review of previously reported variants
Authors: Amabile Sonia , Jeffries Lauren , McGrath James M. , Ji Weizhen , Spencer‐Manzon Michele , Zhang Hui , Lakhani Saquib A.
Published: July 2020

Heterozygous variants in the DYNC1H1 gene have been associated chiefly with intellectual disability (ID), malformations in cortical development (MCD), spinal muscular atrophy (SMA), and Charcot–Marie‐Tooth axonal type 20 (CMT), with fewer reports describing other intersecting phenotypes. To better characterize the variable syndromes associated with DYNC1H1, we undertook a detailed analysis of reported patients in the medical literature through June 30, 2019. In sum we identified 200 patients from 143 families harboring 103 different DYNC1H1 variants, and added reports for four unrelated patients identified at our center, three with novel variants. The most common features associated with DYNC1H1 were neuromuscular (NM) disease (largely associated with variants in the stem domain), ID with MCD (largely associated with variants in the motor domain), or a combination of these phenotypes. Despite these trends, exceptions are noted throughout. Overall, DYNC1H1 is associated with variable neurodevelopmental and/or neuromuscular phenotypes that overlap. To avoid confusion DYNC1H1 disorders may be best categorized at this time by more general descriptions rather than phenotype‐specific nomenclature such as SMA or CMT. We therefore propose the terms: DYNC1H1‐related NM disorder, DYNC1H1‐related CNS disorder, and DYNC1H1‐related combined disorder. Our single center's experience may be evidence that disease‐causing variants in this gene are more prevalent than currently recognized.
The study of short‐shot water‐assisted injection molding of short glass fiber reinforced polypropylene
Authors: Yu Zhong , Liu He‐Sheng , Kuang Tang‐Qing , Huang Xing‐Yuan , Chen Zhong‐Shi , Zhang Wei , Zhang Kai
Published: July 2020

water penetration length and fiber orientation (along the melt flow direction) are important indicators for water‐assisted injection molding products of the fiber‐reinforced polymer. The effects of melt short shot size, water injection delay time and water injection pressure on these two important indexes are analyzed theoretically and experimentally. The study found that with the increase of the melt short shot size, the extension of the water injection delay time and the increase of the water injection pressure, the water penetration length changed from 216 to 96 mm, 170 to 210 mm, and 215 to 180 mm, respectively. Therefore, it can be known that melt short shot size has the greatest influence on water penetration length, followed by water injection delay time, and finally water injection pressure. Meantime, due to the fiber orientation and change degree of water‐assisted injection‐molded products along the melt flow direction, the fiber orientation in the water channel layer along the melt flow direction has the highest and lowest change degree, followed by the wall layer and finally the core layer. It can be known that the melt short shot size has the greatest influence on the fiber orientation and the degree of change along the melt flow direction, followed by the water injection delay time, and finally the water injection pressure.
Personal response systems through the prism of students' experiences
Authors: Mishra Deepti , Chew Esyin , Ostrovska Sofiya , Wong Jojo
Published: July 2020

Personal response systems (PRSs) today offer an opportunity to the field of education in terms of improving teaching and learning outcomes through active engagement in classrooms. The present paper investigates students' attitudes to different types of PRSs, namely, Socrative and Clickers. Both qualitative and quantitative data are gathered and classified. The performed thematic analysis reveals major categories within the framework of this study, namely educational efficacy, psychological aspects, technology‐related issues, and administrative issues. It has been found that Socrative fares better in the “educational efficacy” and “administrative issues,” whereas Clickers outperforms Socrative in the “technological‐related issues.” It is worth pointing out that both Socrative and Clickers are tantamount in “psychological aspects” yielding no negative experiences. The results of this study reveal that two main factors, cost and technological infrastructure, are determinative in the incorporation and appreciation of such systems in an educational setting.
Association of sonographic features and molecular subtypes in predicting breast cancer disease outcomes
Authors: Wang Haoyu , Yao Jiejie , Zhu Ying , Zhan Weiwei , Chen Xiaosong , Shen Kunwei
Published: July 2020

Background

Features in preoperative ultrasound could predict the prognosis of triple‐negative breast cancer (TNBC), while its prognostic value in other molecular subtypes of breast cancer (BC) was unknown. The study aimed to assess the prognostic value of preoperative sonographic features, including orientations, on long‐term outcomes in BC and its association with different molecular subtypes.

Methods

Women diagnosed with invasive BC > 5 mm who underwent surgery were retrospectively reviewed. Clinical, pathological, and sonographic profiles were collected and recurrence‐free survival (RFS) and breast cancer‐specific survival (BCSS) were reported. Interactions between clinicopathological features and tumor orientations in predicting RFS and BCSS were analyzed. Competing risk model was performed to estimate prognostic values of sonographic features for RFS and BCSS.

Results

A total of 2812 patients were included. With a median follow‐up of 60.0 months, 268 (9.5%) patients suffered from recurrences and 104 (3.7%) died of BC. The prognostic values of vertical orientation in predicting RFS (P = .001) and BCSS (P = .001) were strongly associated with molecular subtypes. Non‐TNBC tumors with vertical orientation had less recurrence events compared with parallel orientation (6.3% vs 8.7%, P = .035), whereas failed to predict disease outcomes in multivariate analysis (P > .05). Oppositely, in TNBC, vertical orientation was associated with worse RFS (HR = 3.50; 95% confidence interval [CI] 1.69‐7.24; P < .001) and BCSS (HR = 6.36; 95% CI 2.86‐14.14; P < .001) in multivariate analysis with a 5‐year RFS and BCSS of 73.4% and 74.6%. Meanwhile, vertical orientation was related with smaller tumor size (P < .001), human epidermal growth factor receptor 2 nonamplification (P < .001), and lower Ki‐67 expression (P = .001) among non‐TNBC population, whereas TNBC tumors with vertical orientation had a higher burden of axillary lymph node metastases (2.8 ± 1.0 vs 1.4 ± 0.2, P = .001).

Conclusions

Prognostic values of sonographic orientation in predicting BC disease outcomes were associated with molecular subtypes. Vertical orientation in preoperative sonogram may serve as a prognostic biomarker for TNBC patients.
Production of Propene from n‐Butanol: A Three‐Step Cascade Utilizing the Cytochrome P450 Fatty Acid Decarboxylase OleTJE
Authors: Bauer Daniel , Zachos Ioannis , Sieber Volker
Published: July 2020

Propene is one of the most important starting materials in the chemical industry. Herein, we report an enzymatic cascade reaction for the biocatalytic production of propene starting from n‐butanol, thus offering a biobased production from glucose. In order to create an efficient system, we faced the issue of an optimal cofactor supply for the fatty acid decarboxylase OleTJE, which is said to be driven by either NAD(P)H or H2O2. In the first system, we used an alcohol and aldehyde dehydrogenase coupled to OleTJE by the electron‐transfer complex putidaredoxin reductase/putidaredoxin, allowing regeneration of the NAD+ cofactor. With the second system, we intended full oxidation of n‐butanol to butyric acid, generating one equivalent of H2O2 that can be used for the oxidative decarboxylation. As the optimal substrate is a long‐chain fatty acid, we also tried to create an improved variant for the decarboxylation of butyric acid by using rational protein design. Within a mutational study with 57 designed mutants, we generated the mutant OleTV292I, which showed a 2.4‐fold improvement in propene production in our H2O2‐driven cascade system and reached total turnover numbers >1000.
Fingerprinting of wheat protein profiles for improved distinction between wheat cultivars and species
Authors: Pronin Darina , Geisslitz Sabrina , Börner Andreas , Scherf Katharina A.
Published: July 2020

Background and objectives

Wheat protein composition is commonly characterized by reversed‐phase (RP)‐HPLC‐UV after extraction of albumins/globulins, gliadins (ω5‐, ω1,2‐, α‐, and γ‐gliadins), and glutenins (high‐ and low‐molecular‐weight glutenin subunits). However, this traditional classification does not consider the individual distribution of peaks, resulting in loss of information on protein fingerprints. We developed a new approach to peak integration and evaluated its suitability to differentiate between wheat cultivars and species.

Findings

Integration events were performed every 20 s, and the relative proportions of the peaks were calculated. We compared the traditional and new integration methods on two sample sets, the first comprising 60 common wheat cultivars from 1891 to 2010 and the second comprising 40 common wheat, spelt, durum wheat, emmer, and einkorn cultivars. The new integration method performed better in differentiating old and modern common wheat cultivars and was also applicable to different wheat species.

Conclusions

Unique cultivars were identified that stood out because of their protein composition. Four samples warrant further research to identify the specific proteins that are responsible for the differences.

Significance and novelty

The new integration allowed us to map the cultivar‐ and species‐specific fingerprints, identify cultivars with exceptional protein composition, and group similar cultivars.
Titanium‐catalyzed esterification reactions: beyond Lewis acidity
Authors: Wolzak Lukas A. , van der Vlugt Jarl Ivar , van den Berg Keimpe J. , Reek Joost N. H. , Tromp Moniek , Korstanje Ties J.
Published: July 2020

Esterification is a key reaction and is used in many synthetic and industrial processes, yet the detailed mechanism of operation of often‐used (Lewis acid) catalysts is unknown and subject of little research. Here, we report on mechanistic studies of a titanium aminotriphenolate catalyst, using stoichiometric and catalytic reactions combined with kinetic data and density functional theory (DFT) calculations. While often only the Lewis acidity of the Ti‐center is taken into account, we found that the amphoteric nature of this catalyst, combining this Lewis acidity with Brønsted basicity of a Ti‐bound and in situ formed carboxylate group, is crucial for catalytic activity. Furthermore, hydrogen bonding interactions are essential to pre‐organize substrates and to stabilize various intermediates and transition states and thus enhancing the overall catalytic reaction. These findings are not only applicable to this class of catalysts, but could be important for many other esterification catalysts.
Acyclic Cucurbit[n]uril‐Type Receptors: Aromatic Wall Extension Enhances Binding Affinity, Delivers Helical Chirality, and Enables Fluorescence Sensing
Authors: Murkli Steven , Klemm Jared , King David , Zavalij Peter Y. , Isaacs Lyle
Published: July 2020

We report the linear extension from M1 to M2 to anthracene walled M3 which adopts a helical conformation (X‐ray) to avoid unfavorable interactions between sidewalls. M3 is water soluble (=30 mm) and displays enhanced optical properties (ϵ=1.28×105 m−1 cm−1, λmax=370 nm) relative to M2. The binding properties of M3 toward guests 1–29 were examined by 1H NMR and ITC. The M3⋅guest complexes are stronger than the analogous complexes of M2 and M1. The enhanced binding of M3 toward neuromuscular blockers 25, 27–29 suggests that M3 holds significant promise as an in vivo reversal agent. The changes in fluorescence observed for M3⋅guest complexes are a function of the relative orientation of the anthracene sidewalls, guest concentration, Ka, and guest electronics which rendered M3 a superb component of a fluorescence sensing array. The work establishes M3 as a next generation sequestering agent and a versatile component of fluorescence sensors.
The Butterfly Complex [{Cp*Cr(CO)3}2(μ,η1:1‐P4)] as a Versatile Ligand and Its Unexpected P1/P3 Fragmentation
Authors: Grünbauer Rebecca , Balázs Gábor , Scheer Manfred
Published: July 2020

The versatile coordination behavior of the P4 butterfly complex [{Cp*Cr(CO)3}2(μ,η1:1‐P4)] (1) towards Lewis acidic pentacarbonyl compounds of Cr, Mo and W is reported. The reaction of 1 with [W(CO)4(nbd)] (nbd=norbornadiene) yields the complex [{Cp*Cr(CO)3}2(μ3,η1:1:1:1‐P4){W(CO)4}] (2) in which 1 serves as a chelating P4 butterfly ligand. In contrast, reactions of 1 with [M(CO)4(nbd)] (M=Cr (a), Mo (b)) result in the step‐wise formation of [{Cp*Cr(CO)2}2(μ3,η3:1:1‐P4){M(CO)5}] (3 a,b) and [{Cp*Cr(CO)2}2‐(μ4,η3:1:1:1‐P4){M(CO)5}2] (4 a,b) which contain a folded cyclo‐P4 unit. Complex 4 a undergoes an unprecedented P1/P3‐fragmentation yielding the cyclo‐P3 complex [Cp*Cr(CO)2(η3‐P3)] (5) and the as yet unknown phosphinidene complex [Cp*Cr(CO)2{Cr(CO)5}2(μ3‐P)] (6). The identity of 6 is confirmed by spectroscopic methods and by the in situ formation of [{Cp*Cr(CO)2(tBuNC)}P{Cr(CO)5}2(tBuNC)] (7). DFT calculations throw light on the bonding situation of the reported products.
Neue Materialien
Authors: Schubert Ulrich
Published: July 2020

Für Eigenschaften und damit Anwendungen von Materialien spielt nicht nur die chemische Zusammensetzung eine entscheidende Rolle, sondern auch strukturelle Parameter wie Kristallinität, Porosität, Dimensionalität oder makroskopische Form. „Neue Materialien“ sind durch die zielgerichtete Erschließung neuer Materialgruppen charakterisiert. Als Beispiele dafür werden Perowskite, metallorganische Gerüstverbindungen (MOF), metallische Gläser und anorganisch‐organische Hybridmaterialien exemplarisch diskutiert. Am Beispiel SiO2 wird gezeigt, wie bei Materialsynthesen verschiedene Methoden zum Einsatz kommen müssen, um unterschiedliche Erscheinungsformen der gleichen chemischen Verbindung zu erhalten. Eine herausfordernde Zukunftsaufgabe ist die Entwicklung von Materialsystemen, bei denen die Einzelkomponenten synergetisch zusammenwirken, um Eigenschaften oder Eigenschaftskombinationen zu erzielen, die über jene der Einzelkomponenten in nicht‐trivialer Weise hinausgehen.
The entorhinal cortex of the monkey: VI. Organization of projections from the hippocampus, subiculum, presubiculum, and parasubiculum
Authors: Witter Menno P. , Amaral David G.
Published: July 2020

The organization of projections from the macaque monkey hippocampus, subiculum, presubiculum, and parasubiculum to the entorhinal cortex was analyzed using anterograde and retrograde tracing techniques. Projections exclusively originate in the CA1 field of the hippocampus and in the subiculum, presubiculum, and parasubiculum. The CA1 and subicular projections terminate most densely in Layers V and VI of the entorhinal cortex, with sparser innervation of the deep portion of Layers III and II. Entorhinal projections from CA1 and the subiculum are topographically organized such that a rostrocaudal axis of origin is related to a medial‐to‐lateral axis of termination. A proximodistal axis of origin in CA1 and distoproximal axis in subiculum are related to a rostrocaudal axis of termination in the entorhinal cortex. The presubiculum sends a dense, bilateral projection to caudal parts of the entorhinal cortex. This projection terminates most densely in Layer III with sparser termination in Layers I, II, and V. The same parts of entorhinal cortex receive a dense projection from the parasubiculum. This projection terminates in Layers III and II. Both presubicular and parasubicular projections demonstrate the same longitudinal topographic organization as the projections from CA1 and the subiculum. These studies demonstrate that: (a) hippocampal and subicular inputs to the entorhinal cortex in the monkey are organized similar to those described in nonprimate species; (b) the topographic organization of the projections from the hippocampus and subicular areas matches that of the reciprocal projections from the entorhinal cortex to the hippocampus and the subicular areas.
Urban spatial location service prediction algorithm based on fast adaptive genetic algorithm‐least squares support vector machine under the background of Internet of Things
Authors: Xia Xiangli , Cheng Wei , Yang Liu
Published: July 2020

With the hot issues such as smart city and ecological city put forward, the development of intelligence and informatization of urban space has been established, especially the Internet of Things. With the wide application of location‐based social networks, users can share their location of interest in location. By analyzing users' historical geographic information, location service recommendation can recommend geographic locations to users to help users obtain better access experience. Combined with genetic algorithm (GA) algorithm, a recommendation algorithm based on geographic location service optimization is proposed, which can better recommend to users. Aiming at the problem of slow convergence speed of GA, a fast adaptive genetic algorithm (FAGA) method is proposed to optimize location services. In the experimental part, comparing several functions, FAGA's test effect and convergence are ideal. By comparing FAGA‐least squares support vector machine (LSSVM) algorithm with other methods in location service recommendation, FAGA‐LSSVM method has more advantages.
FIPA‐based reference architecture for efficient discovery and selection of appropriate cloud service using cloud ontology
Authors: Abbas Ghulam , Mehmood Amjad , Lloret Jaime , Raza Muhammad Summair , Ibrahim Muhammad
Published: July 2020

Cloud computing is considered the latest emerging computing paradigm and has brought revolutionary changes in computing technology. With the advancement in this field, the number of cloud users and service providers is increasing continuously with more diversified services. Consequently, the selection of appropriate cloud service has become a difficult task for a new cloud customer. In case of inappropriate selection of a cloud services, a cloud customer may face the vendor locked‐in issue and data portability and interoperability problems. These are the major obstacles in the adoption of cloud services. To avoid these complexities, a cloud customer needs to select an appropriate cloud service at the initial stage of the migration to the cloud. Many researches have been proposed to overcome the issues, but problems still exist in intercommunication standards among clouds and vendor locked‐in issues. This research proposed an IEEE multiagent Foundation for Intelligent Physical Agent (FIPA) compliance multiagent reference architecture for cloud discovery and selection using cloud ontology. The proposed approach will mitigate the prevailing vendor locked‐in issue and also alleviate the portability and interoperability problems in cloud computing. To evaluate the proposed reference architecture and compare it with the state‐of‐the‐art approaches, several experiments have been performed by utilizing the commonly used performance measures. Analysis indicates that the proposed approach enables significant improvements in cloud service discovery and selection in terms of search efficiency, execution, and response time.
Reflect, plan, and implement actions for disability services during pandemic
Authors: Bedrossian Louise
Published: July 2020

The emergence and spread of COVID‐19 this year has drastically changed the climate and functioning in higher education, creating great uncertainty. The impending return to on‐campus activities requires that disability services providers be prepared to meet unique and varied challenges across their campuses.
Danon disease is an underdiagnosed cause of advanced heart failure in young female patients: a LAMP2 flow cytometric study
Authors: Gurka Jiri , Piherova Lenka , Majer Filip , Chaloupka Anna , Zakova Daniela , Pelak Ondrej , Krebsova Alice , Peichl Petr , Krejci Jan , Freiberger Tomas , Melenovsky Vojtech , Kautzner Josef , Kalina Tomas , Sikora Jakub , Kubanek Milos
Published: July 2020

Aims

Danon disease (DD) is a rare X‐linked disorder caused by mutations in the lysosomal‐associated membrane protein type 2 gene (LAMP2). DD is difficult to distinguish from other causes of dilated or hypertrophic cardiomyopathy (HCM) in female patients. As DD female patients regularly progress into advanced heart failure (AHF) aged 20–40 years, their early identification is critical to improve patient survival and facilitate genetic counselling. In this study, we evaluated the prevalence of DD among female patients with non‐ischemic cardiomyopathy, who reached AHF and were younger than 40 years.

Methods and results

The study cohort comprised 60 female patients: 47 (78%) heart transplant recipients, 2 (3%) patients treated with ventricular assist device, and 11 (18%) patients undergoing pre‐transplant assessment. Aetiology of the cardiomyopathy was known in 15 patients (including two DD patients). LAMP2 expression in peripheral white blood cells (WBC) was tested by flow cytometry (FC) in the remaining 45 female patients. Whole exome sequencing was used as an alternative independent testing method to FC. Five additional female DD patients (two with different novel LAMP2 mutations) were identified by FC. The total prevalence of DD in this cohort was 12%. HCM phenotype (57% vs. 9%, *P = 0.022) and delta waves identified by electrocardiography (43% vs. 0%, **P = 0.002) were significantly more frequent in DD female patients.

Conclusions

Danon disease is an underdiagnosed cause of AHF in young female patients. LAMP2 expression testing in peripheral WBCs by FC can be used as an effective screening/diagnostic tool to identify DD in this patient population.
Daylight luminescence system for silicon solar panels based on a bias switching method
Authors: Guada Miguel , Moretón Ángel , Rodríguez‐Conde Sofía , Sánchez Luis Alberto , Martínez Mario , González Miguel Ángel , Jiménez Juan , Pérez Leonardo , Parra Vicente , Martínez Oscar
Published: July 2020

Among the many characterization techniques for solar panel testing, two, electroluminescence (EL) and photoluminescence (PL), can provide useful visual information about the presence of different types of cell defects. EL is performed outdoors by night in commercial solar plants due to the very weak luminescence emission compared to sunlight. PL faces the added difficulty of needing to find a large‐area homogeneous light source to excite the modules. Since nighttime work poses many drawbacks and risks, a daylight outdoor EL/PL system would be useful for offering safe inspection of solar plants. We present daylight luminescence techniques based on a bias switching method, in which a pulsed luminescence signal is obtained by alternating the polarization state of the solar panels, synchronizing it with the luminescence image detection by an InGaAs camera. Fast switching and selecting an optimized exposure time are key to achieving high‐quality images. The daylight luminescence method described herein allows both EL and PL luminescence images to be obtained, even under high solar irradiance conditions.
Secrecy outage probability in energy harvesting aided underlay cognitive radio network under eavesdroppers scenarios
Authors: Odeyemi Kehinde O. , Owolawi Pius A. , Olakanmi Oladayo O.
Published: July 2020

In this paper, the secrecy outage probability (SOP) of an energy harvesting aided underlay single input multiple output cognitive radio network under the multiple eavesdroppers is investigated. It is assumed that all the channels within the network are subjected to Nakagami‐m distributions. In order to quantify the secrecy performance of the concerned network, two eavesdroppers' scenarios are considered and this includes: Colluding Eavesdropping and noncolluding Eavesdropping. Based on these, the SOP closed‐form expressions are derived for the network under the two scenarios. Our findings illustrate that the network under the noncolluding eavesdropping scenario achieve better secrecy outage performance compared with colluding eavesdropping mode. Furthermore, the impact of number of eavesdroppers Ne, the number of antennas equipped at eavesdroppers Ae as well as fading parameter of the wiretap channel me on the network secrecy outage performance are demonstrated. Finally, the accuracy of the derived expressions is validated through the Monte‐Carlo simulations.
Impact of antimicrobial stewardship and rapid diagnostics in children with Staphylococcus aureus bacteremia
Authors: Welch Stephanie N. , Patel Rupal M. , Morris Lee E. , Dassner Aimee M. , Rozario Nigel L. , Forrester Jeanne B.
Published: July 2020

Introduction

Rapid diagnostic testing (RDT) in combination with antimicrobial stewardship programs (ASPs) has been associated with improved outcomes in adults with Staphylococcus aureus bacteremia (SAB); however, pediatric data are limited.

Objectives

The primary objective of this study was to assess the clinical impact of concomitant implementation of an ASP and RDT in children with SAB.

Methods

This pre‐post quasi‐experimental study compared time to optimal antibiotic in children with SAB in 2015/2016 (pre‐intervention [PRE]) and 2017/2018 (post‐intervention [POST]). During the PRE period there was no RDT or ASP available. However, in the POST period, RDT was performed on all positive blood cultures, followed by feedback from an ASP. Secondary outcomes included time to effective antibiotic, antibiotic exposure, duration of bacteremia, hospital length of stay (LOS), transfer to the intensive care unit (ICU), SAB recurrence, and inpatient mortality.

Results

Sixty‐eight patients were included in the study (PRE: n = 32, POST: n = 36). Median time to optimal antibiotic therapy decreased by 23 hours (PRE: 44.3 hours vs POST: 21.3 hours; P = .008). Duration of bacteremia (PRE: 65 hours vs POST: 40.9 hours; P = .03) and inpatient mortality (PRE: 12.5% vs POST: 0%; P = .04) were also reduced. However, further review revealed that only one death was related to SAB. Differences in time to effective therapy, antibiotic exposure, and hospital LOS were not significantly different between the groups. There were similar rates of infectious disease (ID) consultation (PRE: 78% vs POST: 89%, P = .23), but a shorter time to central line removal in the POST group (PRE: 68.2 hours vs POST: 19.8 hours; P = .04). Throughout the study period, recurrence of SAB only occurred in one patient (PRE).

Conclusion

ASP interventions, facilitated by RDT, resulted in a shorter time to optimal antibiotic therapy in children with SAB. Although these interventions may have led to improved overall SAB management, further studies are needed to confirm clinical benefits.