bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanisms for Microseismicity Occurrence Due to CO2 Injection at Decatur, Illinois: A Coupled Multiphase Flow and Geomechanics Perspective
Authors: Silva Josimar A. , Khosravi Mansour , Yoon Hongkyu , Fehler Michael , Frailey Scott , Juanes Ruben
Published: May 2024

We numerically investigate the mechanisms that resulted in induced seismicity occurrence associated with CO2 injection at the Illinois Basin–Decatur Project (IBDP). We build a geologically consistent model that honors key stratigraphic horizons and 3D fault surfaces interpreted using surface seismic data and microseismicity locations. We populate our model with reservoir and geomechanical properties estimated using well-log and core data. We then performed coupled multiphase flow and geomechanics modeling to investigate the impact of CO2 injection on fault stability using the Coulomb failure criteria. We calibrate our flow model using measured reservoir pressure during the CO2 injection phase. Our model results show that pore-pressure diffusion along faults connecting the injection interval to the basement is essential to explain the destabilization of the regions where microseismicity occurred, and that poroelastic stresses alone would result in stabilization of those regions. Slip tendency analysis indicates that, due to their orientations with respect to the maximum horizontal stress direction, the faults where the microseismicity occurred were very close to failure prior to injection. These model results highlight the importance of accurate subsurface fault characterization for CO2 sequestration operations.
Retailers’ Compliance with Federal Age of Cigarette Sales Policies – Pitt County, North Carolina, January–March 2022
Authors: Lee Joseph G. L. , Sesay Mahdi , van de Venne Judy , Kong Amanda Y. , Hrywna Mary , Rose Shyanika W. , Delnevo Cristine D.
Published: May 2024

Background

Tobacco use remains a leading cause of preventable morbidity and premature mortality. In December 2019, the federal age of sale for tobacco products increased from age 18 to age 21. This study aimed to evaluate the implementation of federal Tobacco 21 policies in Pitt County, North Carolina, by conducting multiple purchase attempts for cigarettes.

Methods

Stores in Pitt County that sold cigarettes were randomly sampled and visited by up to six different underage buyers (aged 18–20 years) who attempted to buy cigarettes from January to March 2022. Buyers made a total of 217 cigarette purchase attempts from 49 Pitt County retailers. Analyses were conducted using SPSS Complex Samples (v.28/Macintosh) to estimate retailer prevalence of requesting identification (ID) and selling to underage buyers across multiple purchase attempts.

Results

On average, retailers failed to request ID in 15.4% of purchase attempts (95% CI; 9.4%–21.3%) and sold to an underage buyer 34.2% of the time (95% CI; 27.0%–41.4%). Additionally, 75.5% (95% CI; 63.4%–84.6%) of retailers sold to an underage buyer at least once.

Limitations

This study is limited to a single county in North Carolina and to underage buyers aged 18 to 20 years.

Conclusions

There is widespread noncompliance with federal age-of-sale policies for tobacco products in Pitt County, North Carolina. State enforcement is warranted, and North Carolina’s youth access law should be amended to match the federal age of sale. Changes to the law should allow research involving underage purchases.
Psychiatric Residential Treatment Facilities for Child Behavioral Health Services in North Carolina Medicaid
Authors: Lanier Paul , Rose Roderick , Gibbs Daniel , Hyman Jacob , Kamdar Neil , Konstanzer Joseph , Hassmiller Lich Kristen
Published: May 2024

Background

Psychiatric residential treatment facilities (PRTFs) are non-hospital inpatient treatment settings for children with severe be­havioral health disorders. PRTFs are a restrictive and costly form of care that can potentially be avoided with community-based behavioral health services.

Methods

Statewide Medicaid enrollment and claims data for 2015–2022 were used to describe PRTF utilization in North Carolina. We examined annual episodes of care in PRTFs and compared trends before and during the COVID-19 public health emergency.

Results

From 2015 to 2022, 10,038 children insured by NC Medicaid entered a PRTF across 10,966 episodes of care. In the past five years (2018–2022), care in PRTFs resulted in Medicaid expenditures of over $550 million total, or over $100 million per year. In 2022, 42% of children who entered PRTFs were in foster care and 44% of children were placed in PRTFs outside of North Carolina.

Limitations

The analysis was limited to data collected for administrative purposes.

Conclusions

Current trends indicate an ongoing overrepresentation of children in foster care placed in PRTFs and increased out-of-state PRTF placements. Coordinated efforts in future research, policy, and practice are needed to determine the cause of these trends and iden­tify solutions.
Factors Associated with Substance Use Disorder among High-Need Adolescents and Young Adults in North Carolina
Authors: Hughes Phillip M. , Annis Izabela E. , deJong Neal A. , Christian Robert B. , Davis Scott A. , Thomas Kathleen C.
Published: May 2024

Background

Prevalence of substance use disorders (SUD) is high among adolescents and young adults (AYAs) with complex medical needs. Little is known about risk factors for SUD in this population.

Methods

This retrospective cohort study used electronic health record data from a large academic hospital system (2015–2019) to identify adolescents (aged 10–17) and young adults (aged 18–27) with intellectual/developmental disorders, psychiatric conditions, or complex

medical conditions. Logistic regression was used to identify demographic, clinical, and neighborhood-level risk factors associated with SUD in this population.

Results

A total of 149 adolescents and 536 young adults had a SUD diagnosis (6.7% and 20.6%, respectively). Among adolescents, notable risk factors for SUD included age (adjusted odds ratio [aOR] = 1.42, 95% confidence interval [CI] = [1.31, 1.54]), Hispanic ethnicity (aOR = 2.10, 95% CI = [1.10, 3.99]), additional psychoactive medication classes (aOR = 1.27, 95% CI = [1.11, 1.46]), and living in a “high” child opportunity index (COI) (aOR = 2.06, 95% CI [1.02, 4.14]) or a “very high” COI (aOR = 3.04, 95% CI [1.56,5.95]) area. Among young adults, notable risk factors included being male (aOR = 2.41, 95% CI [1.91, 3.05]), being Black (aOR = 1.64, 95% CI [1.28, 2.09]), and additional non-psychoactive (aOR = 1.07, 95% CI [1.03, 1.11]) or psychoactive medication classes (aOR = 1.17, 95% CI [1.07, 1.28]).

Limitations

These descriptive analyses are limited to one large academic hospital system in North Carolina and may not be representative of all high-need AYAs in the state.

Conclusions

Several demographic, clinical, and neighborhood risk factors are associated with SUD in high-need AYAs.
Interprofessional Education at the University Level: Evidence, Models, and Future Directions
Authors: McCullough Gary H. , Powers Kelly , Watts-Isley Jaimee , Brown Paige , Smith Susan , Vaughn Jacqueline T.
Published: May 2024

Interprofessional education (IPE) continues to evolve as a critical component of providing quality health care. Emerging evidence suggests IPE is most effective if it exists across the continuum of academia to clinical practice. This article provides current evidence and models for IPE deliv­ery to students beginning in their academic programs.
Developing IPEC Competencies for an Evolving Professional Landscape: Q&A with Jeffery Stewart, DDS
Authors: Zomorodi Meg
Published: May 2024

Jeffery Stewart, DDS, MS, a consultant to the American Dental Education Association, met with Meg Zomorodi, PhD, RN, ANEF, FAAN, of UNC-Chapel Hill, to discuss the latest revisions to the IPEC Core Competencies for Interprofessional Collaborative Practice.

Released in November 2023, these updated competencies build on previous versions from 2011 and 2016 to incorporate the perspectives of seven new IPEC member organizations and reflect the continuously evolving research, policy, education, and practice landscape.
Building and Supporting Interprofessional Teams to Support Population Health
Authors: Rivers Livsey Kae , Aliaga Sofia , Wells Jennifer
Published: May 2024

High-functioning teams can positively impact health care delivery and support population health. The authors discuss enabling and interfering factors that impact team-based care delivery and how the AHEC system can promote inter­professional education and practice across North Carolina.
Behavioral Health Access and Workforce Competence for Integrated Care: Highlighting Interprofessional Initiatives from Two North Carolina Social Work Programs
Authors: Kulkarni Shanti , White Marie , Reinsmith-Jones Kelley , Powers Kelly
Published: May 2024

Effective team-based care is necessary for implementation of the integrated care models recommended to improve behavioral health access. Many models rely on social work­ers who are trained to deliver behavioral health care as an interprofessional team member. In this article, we highlight two social work programs utilizing interprofessional educa­tion to enhance team-based care competence.
Assessing Interprofessional Collaboration at Clinical Learning Sites: Methodology on Developing the IP-CLEAR Tool
Authors: Sanders Kimberly A. , Lynn Mary R.
Published: May 2024

Interprofessional Clinical Learning Environment Assessment and Reflection (IP-CLEAR) tool was developed by a team of faculty from the schools of nursing, pharmacy, and medicine at University of North Carolina at Chapel Hill (UNC-CH), with the support of the North Carolina Area Health Education Consortium (NC AHEC) and the UNC-CH

Office of Interprofessional Education and Practice (IPEP). The IP-CLEAR tool is intended for use by clinical sites that have or want to have clinical learners engaged and integrated into an excellent interprofessional CLE. The development of the IP-CLEAR and projections for future work are described here.
Fostering Psychological Safety: Building Team-Based Care Communication Skills
Authors: de Saxe Zerden Lisa , Zomorodi Meg
Published: May 2024

As health systems continue to advance integrated models of care, communication remains a central facet of how interprofessional team members can concurrently address physical health, behavioral health, and

social needs.
“It Takes a Village”- A Conversation with the Interprofessional Diabetes Clinic at the ECU Health Family Medicine Center
Authors: Lysaght Christine , Messenger Jamie , Patil Shiv , Craven Kay
Published: May 2024

Interprofessional collaboration and shared understanding positively impact both patients and providers. Current

recommendations from the CDC and experts agree that

collaboration between diverse professions is necessary to improve patient outcomes and empower patients to selfmanage their chronic conditions.
The effects of omega-3 fatty acids on antioxidant enzyme activities and nitric oxide levels in the cerebral cortex of rats treated ethanol
Authors: Oktar Süleyman , Karadeniz Mahinur , Acar Musa , Zararsız İsmail
Published: May 2024

The toxic effect of ethanol on the cerebral cortex and protective effects of omega-3 fatty acids against this neurotoxicity were investigated. Twenty eight male Wistar-albino rats were divided into 4 groups. Rats of the ethanol and ethanol withdrawal groups were treated with ethanol (6 g/kg/day) for 15 days. Animals of the ethanol+omega-3 group received omega-3 fatty acids (400 mg/kg daily) and ethanol. In rats of the ethanol group SOD activity was lower than in animals of the control group. In rats treated with omega-3 fatty acids along with ethanol SOD, activity increased. GSH-Px activity and MDA levels in animals of all groups were similar. In ethanol treated rats NO levels significantly decreased as compared to the animals of the control group (6.45±0.24 nmol/g vs 11.05±0.53 nmol/g, p
Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning
Authors: Pavithra SS , Hegde Y Siddarth , Shetty Kaushal
Published: May 2024

An epidemiological shift has occurred in India, where the burden of chronic illnesses is increasing, and communicable diseases are declining. Chronic diseases such as diabetes mellitus, cancer, and chronic respiratory disorders are on the rise, and this trend has been attributed to unhealthy lifestyles, increased urbanization, and changes in society and the environment. Such a category did not include chronic kidney disease (CKD). End-stage renal disease (ESRD) is defined as glomerular filtration rate (GFR) <15 ml/min/1.73 m2, while chronic kidney disease (CKD) is defined as a sustained eGFR of <60 ml per minute per 1.73 m2 of body-surface area for more than three months irrespective of the underlying cause while glomerular filtration rate (GFR) <15 ml/min/1.73 m2 is considered as end-stage renal disease (ESRD). CKD is classified into five stages ranging from mild dysfunction to complete failure. Globally, CKD is a significant cause of morbidity and death and there is a 38% increase in mortality linked to renal failure in developing nations like India. It has been shown that the epidemiology of CKD in India differs from that in the West; patients in India were, on average, five to twenty years younger Pregnancy-related malnutrition, environmental variables, genetics, or postponed medical care that accelerates the course of CKD are among the likely reasons and birth weight.

The present hospital-based, cross-sectional, observational study was conducted in the a tertiary care teaching hospital in South India from December 2020 to January 2024.

The study comprised 50 patients of CKD between 30 and 70 years of age of both sexes with no previous history of any thyroid dysfunction, while 50 apparently healthy age and sex-matched individuals from the same ethnic population with normal renal function and no past history of thyroid disorders served as a control group.

The results of this study and most others, there is a possibility that abnormal thyroid hormone activity may result in a decline in renal function. Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning.

The current cross-sectional hospital-based observational study discovered that uremic patients had considerably lower mean TT3 and TT4 and higher mean TSH when compared to healthy controls, regardless of the kind of medication or duration of the disease. Based on the results of this study and most others, there is a possibility that abnormal thyroid hormone activity may result in a decline in renal function. Early identification of thyroid illness and its intricate relationship to renal function may be crucial for therapy planning.
ADMA, neutrophil to lymphocyte, platelet to lymphocyte ratios and phase angle: effects on inflammation and nutrition in hemodialysis patients
Authors: Gürlek Demirci Bahar , Karakan Mine Şebnem
Published: May 2024

Objectives: Neutrophil/lymphocyte ration (NLR) and platelet/lymphocyte ratio (PLR) levels can be used as systemic infallamotory parameters. Asymmetric dimethyl arginine (ADMA) inhibits endothelial nitric oxide synthase. Phase Angle (PhA) is a potential paremeter to screen for inflammatory abnormalities. In present study we aimed to determine the relations between NLR, PLR, ADMA, and PhA in terms of early markers for nutritonal status in addition to their well-known role in inflammation.
Methods: A total of 89 patients undergoing maintenance hemodialysis 3 days a week at least 6 months were enrolled. To assess nutritional status, we performed the dietary questionnaire and mini nutritional assessment score (MNAS). ADMA was measured by ELISA. NLR and PLR are calculated from monthly complete blood count tests. Patients were divided into 2 groups accordng to NLR levels as group 1 (NLR≥4.6; n=48) ve and group 2 (NLR<4.6, n=41).
Results: The mean ADMA level was 0.03±0.01 µmol/L, the mean PhA was 7.2±1.1º. In subgroup analysis, MNAS, albumin levels and phase angle of patients in group 1 were lower and CRP, PLR, ADMA levels were higher when compared to group 2. In correlation analysis, NLO was positively correlated with PLR, CRP and ADMA however negatively correlated with albumin and PhA levels. In regression analysis, NLR, PLR and ADMA were detected as independent predictors of MNAS.
Conclusion: In conclusion our study suggests that NLR, PLR and ADMA are independent predictors for nutritional status and inflammation in patients ongoing hemodialysis.
Exploring the Unusual: The Use of Chickens in Magic Shows
Authors: McChicken Robert ‘clucky’
Published: May 2024

This article delves into the unconventional yet fascinating practice of incorporating chickens into magic shows. The unique sensory and behavioral characteristics of chickens offer untapped potential in the world of magic. However, ethical considerations in relation to animal welfare must also be addressed.
Die Höhenbefestigungen Samniums vom 4.–1. Jh. v. Chr.
Authors: Hoer Alexander
Published: May 2024

Während der turbulenten Samnitenkriege zwischen Rom und den samnitischen Gemeinschaften im südlichen Zentralitalien spielten die eisenzeitlichen Höhenbefestigungen Samniums eine entscheidende Rolle. Durch eine multidisziplinäre Herangehensweise gelingt es der vorliegenden Studie, unser Verständnis dieser Anlagen deutlich zu erweitern. Auf der Makroebene erlauben es Methoden der physischen Geographie, räumliche Verteilung und topografische Lage der Höhenbefestigungen auf ihre strategischen Aspekte hin zu analysieren. Konstruktion und Nutzung einzelner Fundstellen stehen im Mittelpunkt der archäologischen Untersuchung auf der Mesoebene, während auf der Mikroebene ein ausgewähltes Fallbeispiel mit umfangreichen Survey-Ergebnissen vertiefte Einsichten bietet. Zusätzlich enthält das Buch einen pointierten Katalog aller bekannten Höhenbefestigungen sowie eine neue Kartierung der archäologischen Fundplätze. Auf diese Weise ist es möglich, den Fokus über die einseitigen Narrative der römischen Geschichtsschreibung hinaus auf die nahezu schriftlosen Kulturen dieser Region zu richten. Die Integration archäologischer Befunde und literarischer Quellen lässt die historischen Ereignisse, die die Samnitenkriege prägten, in neuem Licht erscheinen. Dieses Buch bietet somit nicht nur eine vertiefte Analyse der Höhenbefestigungen Samniums, sondern erweitert auch unser Verständnis der Geschichte Italiens und des Aufstiegs Roms zu einer Hegemonialmacht durch archäologische Erkenntnisse.
Autoria partilhada na literatura digital
Authors: Deicke Débora Keppi , Pereira Vinícius Carvalho
Published: May 2024

Na literatura digital, ganham espaço práticas que por vezes transgridem noções mais convencionais de materialidade e autoria advindas da literatura impressa, sobretudo a associação um livro – um tema – um autor. Entre outras importantes obras de literatura digital lusófona, analisamos no presente artigo Fantasia breve, a palavra-espuma, gerador automático de poesia idealizado por Rui Torres, com programação de Nuno Ferreira, baseado em poemas de Ana Hatherly. Interessa-nos, acerca desse projeto, indagar a complexa dinâmica coautoral que se estabelece entre os criadores supracitados e o leitor, o qual também é responsável por aquilo que lê, dado que os poemas de Fantasia breve desaparecem muito rapidamente da tela, impondo ao leitor a necessidade de decidir quais porções do texto ler e quais ignorar. Assim, procuramos observar de que modo idealizador, programador, poetisa e leitor contribuem de maneira distinta e em tempos diferentes de produção/execução/recepção para a construção de sentidos a partir dos poemas automática e aleatoriamente gerados pelo software. Em nossa pesquisa, destacamos como operadores analíticos os conceitos de hiperleitura, combinatória, escrita não criativa e remixagem, e tentamos situar Fantasia breve, a palavra-espuma na série literária lusitana com relação a outros experimentos poéticos combinatório-procedimentais, especialmente a poesia ibérica maneirista e barroca e a poesia experimental portuguesa do século XX.
The Risk Factors of Patients with Cruris Fracture Nonunion in dr. Mohamad Soewandhie Hospital in 2021 - 2022: A Case- Control Study
Authors: Clarissa Regina , Sasono Bimo , Juliasih Ni Njoman
Published: May 2024

Background: The crural region is highly susceptible to injury in Indonesia, with fractures being a common occurrence. However, if not properly treated, these fractures can lead to complications such as nonunion. To investigate the risk factors for nonunion cruris fractures, this study was conducted at Dr. Mohamad Soewandhie Hospital, examining age, gender, working status, education, trauma mechanism, and previous treatment history.
Methods: This case-control study analyzed patient records from 2021-2022 at Dr. Mohamad Soewandhie Hospital, comparing 12 nonunion and 24 union cruris fracture cases. Data on age, gender, work, education, trauma, and treatment history was collected between August and October 2023. Statistical analysis was performed using the Mcnemar and Wilcoxon tests, with a significance level of p < 0.05.
Results: A study of 149 cruris fractures found 12 nonunions, primarily affecting males aged 26-45 or 46-65. Notably, the highest nonunion rate (41.7%) was in the 12-25 age group (p = 0.027). Males were more affected, with 7 nonunion cases (58.3%) (p = 0.041). Working class patients had the highest fracture and nonunion rates (83.3%) (p < 0.001). High school education was most common among nonunion cases (75%) (p = 0.374). High-energy trauma was reported in almost all nonunion cases (91.7%) (p < 0.001). All nonunion patients had a history of ORIF (p = 0.102).
Conclusions: The study revealed that age, gender, work status, and trauma mechanism significantly influenced nonunion cruris fractures at Dr. Mohamad Soewandhie Hospital in 2021-2022. Patient education and past treatment history, however, had no significant impact.
The Application of Posterior Plate in Tibial Plateau Fracture: A Case Report
Authors: Chilmi Muhammad Zaim , Febrian Firas
Published: May 2024

Backgrounds: Tibial plateau fracture is the most frequent type of fracture caused by motor-vehicle collision. This injury may or may not be associated with soft tissue injury, such as the knee's ligaments. Posterior tibial plateau fractures are a rare subtype that requires surgical intervention. This case report describes the outcome of posterior plating in treating a posterior tibial plateau fracture.
Case report: A 41-year-old female patient came to the emergency room (ER) after being involved in a traffic collision. The patient underwent a thorough medical examination, which revealed the tibial eminence avulsion associated with the fracture of the head of the fibula. Surgical treatment was performed using a posterior approach through an inverted L-shaped incision.
Discussion: Tibial plateau fractures are serious injuries that often require surgery. However, the decision to operate depends on several factors, including the morphology of the fracture, the patient's profile, the condition of the soft tissues, and the expected recovery of the articular surface and the axis of the limb.
Conclusion: A surgical technique using a posterior approach through an inverted L-shaped incision with a small medial T-plate, lateral bone graft, and roof K-wire fixation demonstrates positive outcomes for treating closed posterior tibial plateau fractures and avulsion fractures of the tibial eminence.
Isocucurbitacin B inhibits glioma growth through PI3K/AKT pathways and increases glioma sensitivity to TMZ by inhibiting hsa-mir-1286a
Authors: Han Mingyu , An Junsha , Li Sui , Fan Huali , Wang Li , Du Qing , Du Junrong , Yang Yuxin , Song Yuqin , Peng Fu
Published: May 2024

Aim: Glioma accounts for 81% of all cancers of the nervous system cancers and presents one of the most drug-resistant malignancies, resulting in a relatively high mortality rate. Despite extensive efforts, the complete treatment options for glioma remain elusive. The effect of isocucurbitacin B (isocuB), a natural compound extracted from melon pedicels, on glioma has not been investigated. This study aims to investigate the inhibitory effect of isocuB on glioma and elucidate its underlying mechanisms, with the objective of developing it as a potential therapeutic agent for glioma.

Methods: We used network pharmacology and bioinformatics analysis to predict potential targets and associated pathways of isocuB in glioma. Subsequently, the inhibitory effect of isocuB on glioma and its related mechanisms were assessed through Counting Kit-8 (CCK-8), wound healing, transwell, Western blot (WB), reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and other in vitro experiments, alongside tumor formation experiments in nude mice.

Results: Based on this investigation, it suggested that isocuB might inhibit the growth of gliomas through the PI3K-AKT and MAPK pathways. Additionally, we proposed that isocuB may enhance glioma drug sensitivity to temozolomide (TMZ) via modulation of hsa-mir-1286a. The CCK-8 assay revealed that isocuB exhibited inhibitory effects on U251 and U87 proliferation and outperformed TMZ. Wound healing and transwell experiments showed that isocuB inhibited the invasion and migration of U251 cells by suppressing the activity of MMP-2/9, N-cadherin, and Vimentin. The tunnel and flow cytometry (FCM) assays revealed that isocuB induced cell apoptosis through inhibition of BCL-2. Subsequently, we conducted RT-qPCR and Western blot (WB) experiments, which revealed that PI3K/AKT and MAPK pathways might be involved in the mechanism of the inhibition isocuB on glioma. Additionally, isocuB promoted the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a. Furthermore, we constructed TMZ-resistant U251 strains and demonstrated effective inhibition by isocuB against these resistant strains. Finally, we confirmed that isocuB can inhibit tumor growth in vivo through experiments on tumors in nude mice.

Conclusion: IsocuB may protect against glioma by acting on the PI3K/AKT and MAPK pathways and promote the sensitivity of glioma U251 to TMZ by inhibiting hsa-mir-1286a.
Euclidean Relativity Solves the Hubble Constant Tension
Authors: Niemz Markolf H.
Published: May 2024

Special and general relativity (SR/GR) describe nature “subjectively”, that is, from the perspectives of observers. Despite the Lorentz covariance of SR, the general covariance of GR, and all coordinate-free formulations, the perspective of each observer is egocentric. Even if we consider all egocentric perspectives, we will not craft a “holistic view of nature” (view of nature as a whole and in her own concepts) because there is no absolute time in SR/GR. In Euclidean relativity (ER), there is a relative 4D vector “flow of proper time” and also an absolute cosmic time. ER describes nature “objectively”, that is, independently of all observers. Each object’s (!) proper space d1, d2, d3 and its proper time τ span an absolute 4D Euclidean spacetime (ES), where d1, d2, d3 and d4 = cτ are treated the same. An observer’s reality is created by projecting ES orthogonally to his proper space and to his proper time. The projections are relative. ER compares to the “advanced heliocentric model”, in which the sun is the center of the solar system, but no star is the center of space. This model implies a holistic view of the universe from “beyond” (outside) space. Likewise, ER implies a holistic view of nature from beyond space and time. This makes sense because space and time are subjective concepts. There is a master reality ES (described by ER) beyond each observer’s reality (described by SR/GR). ER solves 15 mysteries (such as time’s arrow, the Hubble constant tension, entanglement). ER also declares five concepts of today’s physics obsolete (such as dark energy, non-locality). The 15 mysteries are solved without any field equations. Physical fields come into play in an observer’s reality only.
Redefining Biodiversity Conservation Through an Outcome Separation Framework
Authors: Trageser Scott , Hamilton Paul
Published: May 2024

The term “conservation,” as it relates to biodiversity in a Western context, has a storied past and as conservation science and societal values have evolved, consensus over its precise meaning has remained elusive. The broad scope of contemporary definitions hampers effective communication during a period of environmental crisis and is troublesome for any derivative concept which aims to empirically quantify the efforts of the conservation sector. This presents an avoidable hindrance to the systematic planning of the conservation field. To help remedy this situation, we provide an outcome separation framework that is based on the expected degree of separation between an action’s proximate outcome, from its intended, ultimate outcome for a habitat and/or species. Framing a definition of conservation through this lens of outcome separation allows for conservation-related actions to be clearly categorized into one of three discrete tiers: primary, secondary, and tertiary. A distillation of this tiered framework also provides a new definition of biodiversity conservation that is more rigorous and adaptable to future conceptual evolutions of the field.
A Study on the Effect of XRF-Escape Process on the Energy Resolution of a Scintillation Detector: The Case of a NaI(Tl) for Medical Imaging or Gamma-Ray Spectroscopy
Authors: Scafè Raffaele , Puccini Marco , Pellegrini Rosanna , Pani Roberto
Published: May 2024

Present work investigates, in photon energy domains of specific interest for medical imaging, the effect of the escape of X-ray fluorescence from the scintillator materials on the energy resolution of scintillation detector itself. Monolithic as well as pixelated crystals differently sized are considered, in the case of the NaI because it is the gold standard in the field. The volumetric ratio is introduced, as a figure of merit, taking into account, alongside the surface-to-volume ratio, the geometric shape, the elemental composition and also the mean-free-path for the given scintillator and energy. The inter-crystal XRF escape is finally suggested to be considered among the effects producing image blurring in segmented scintillatros due to the spread of events between the primary pixel and the first neighbors ones.
Quantum Solution of Classical Turbulence Decaying Energy Spectrum
Authors: Migdal Alexander
Published: May 2024

This paper summarizes and elaborates on recently found \cite{migdal2023exact} exact reduction of decaying turbulence in the Navier-Stokes equation in $3 + 1$ dimensions to a Number Theory problem of the statistical limit of the Euler ensemble. We reformulate the Euler ensemble as a Markov chain and show the equivalence of this formulation to the \textbf{quantum} statistical theory of $N$ fermions on a ring, with an external field related to the random fractions of $\pi$. We find the solution of this system in the turbulent limit $N\to \infty, \nu \to 0$ in terms of a complex trajectory (instanton) providing a saddle point to the path integral over the density of these fermions. This results in an analytic formula for the observable correlation function of vorticity in wavevector space. This is a full solution of decaying turbulence from the first principle without approximations or fitted parameters. We compute resulting integrals in \Mathematica{} and present effective index $n(t) = -t E'(t)/E(t) $ for the energy decay as a function of time Fig.\ref{fig::NPlot} and $s(k)= -k\partial_k \log E(k,t) $ for the energy spectrum Fig.\ref{fig::SPIndex}. The asymptotic values are $n(\infty) = \frac{5}{4}, s(\infty) = \frac{7}{2}$, but the universal functions $n(t), s(t)$ are neither constant nor linear due to quantum effects (complex poles of the Mellin transform at zeros of Riemann zeta function). The theoretical value $n(\infty)=\sfrac{5}{4}$ matches the grid turbulence experiments \cite{GridTurbulence_1966} within experimental errors $\sim 2\%$.
Deep Learning and Machine Learning for Automatic Grapevine Varieties Identification: A Brief Review
Authors: Carneiro Gabriel A. , Cunha António , Sousa Joaquim
Published: May 2024

The Eurasian grapevine (Vitis vinifera L.) is the most widely grown horticultural crop in the world and is important for the economy of many countries. In the wine production chain, grape varieties play an important role as they directly influence the authenticity and classification of the product. Identifying the different grape varieties is therefore fundamental for quality control and inspection activities, as well as for regulating production. Currently, ampelography and molecular analysis are the main approaches to identifying grape varieties. However, both methods have limitations. Ampelography is subjective and prone to errors and is experiencing enormous difficulties as ampelographers are increasingly scarce. On the other hand, molecular analyses are very demanding in terms of cost and time. In this scenario, Deep Learning (DL) and Machine Learning (ML) methods have emerged as a classification alternative to deal with the scarcity of ampelographs and avoid molecular analyses. In this study, the most recent and current methods for identifying grapevine varieties using DL classification-based approaches are presented through a systematic literature review. The classification pipeline of the 31 studies found in the literature was described, highlighting its pros and cons. Most of the studies used DL-based models trained with leaf images acquired in a controlled environment at a maximum distance of 1.2 metres to classify grape varieties. In addition, there is a large gap between practical applications and the datasets used: a great lack of varieties, limited data acquired in the field and a lack of tests on plants under adverse conditions. Potential directions for improving this area of research were also presented.
Modeling Dynamics of Permafrost Degradation and their Impact on Ecosystems Across Entire Alaska: Arctic and Subarctic Engineering Design Tool (Part-1)
Authors: Marchenko Sergey , Bjella Kevin , Nicolsky Dmitry , Romanovsky Vladimir
Published: May 2024

Climate warming is expected to have pronounced effects on Arctic and Subarctic ecosystems, especially regions underlain by discontinuous and relatively warm permafrost. The main goal of this research is to evaluate the vulnerability and dynamics of permafrost under climate warming across the various ecotypes in respect of ecosystem stability, socioeconomic impact, and for better understanding possible future environmental changes. We suggested the new version of the spatially distributed permafrost dynamics model (GIPL2-MPI), which is developed in the Geophysical Institute, University of Alaska Fairbanks. This model is based on the ecosystem approach to simulate the permafrost dynamics, which we are discussing in this paper. We combined ground-based observations and numerical freeze/thaw modeling using climate-ecosystem-permafrost interactions to understand the physical processes and mechanisms controlling permafrost physical state. We predict the changes in permafrost conditions using output from two GCMs (NCAR-CCSM4 and GFDL-CM3) and Five-Model Average Ensemble for the RCP-4.5 and RCP-8.5 scaled down to 1 by 1 km spatial resolution (https://uaf-snap.org/) across entire Alaska. Our result shows that by the end of the current century widespread near-surface permafrost degradation could begin everywhere in Alaska southward of the Brooks Range as well as across some spots at the North Slope Alaska.
Towards Improving YARN performance for Frugal Heterogeneous SBC-based Edge Clusters
Authors: Qureshi Basit
Published: May 2024

Efficient resource allocation is crucial in clusters with frugal Single-Board Computers (SBCs) possessing limited computational resources. These clusters are increasingly being deployed in edge computing environments in resource-constrained settings where energy efficiency and cost-effectiveness are paramount. A major challenge in Hadoop YARN scheduling is load-balancing, as frugal nodes within the cluster can become overwhelmed, resulting in degraded performance and frequent occurrences of out-of-memory errors, ultimately leading to job failures. In this study, we introduce an Adaptive Multi-criteria Selection for Efficient Resource Allocation (AMS-ERA) in Frugal Heterogeneous Hadoop Clusters. Our criterion considers CPU, memory and disk requirements for jobs and aligns the requirements with available resources in the cluster for optimal resource allocation. To validate our approach, we deploy a heterogeneous SBC-based cluster consisting of 11 SBC nodes and conduct several experiments to evaluate the performance using Hadoop wordcount and terasort benchmark for various workload settings. The results are compared to the Hadoop-Fair, FOG and IDaPS scheduling strategies. Our results demonstrate a significant improvement in performance with the proposed AMS-ERA, reducing execution time by 27.2%, 17.4% and 7.6% respectively using terasort and wordcount benchmarks.
Fundamental Physics as the General Solution to a Maximization Problem on the Shannon Entropy of All Measurements
Authors: Harvey-Tremblay Alexandre
Published: May 2024

We present a novel approach to quantum theory construction that involves maximizing the Shannon entropy of quantum measurements relative to their initial preparation. By constraining the maximization problem with a phase that vanish under measurements, we obtain quantum mechanics (vanishing U(1)-valued phase), relativistic quantum mechanics (vanishing Spin^c(3,1)-valued phase), and quantum gravity (vanishing ${\rm SL(4,\mathbb{R})}$-valued phase). The first two cases are equivalent to established theory, whereas the later case yields a quantum theory of accelerated reference frames, in which a quantized version of the Einstein field equation lives. Specifically, the spacetime interval is promoted to an observable, effectively building the metric tensor from the underlying quantum structure. Subsequently, the Schrödinger equation generates metric tensor diffeomorphisms and SO(3,1) transformations. Remarkably, the quantized Einstein Field Equations are provably non-perturbatively finite. Moreover, the SU(3)xSU(2)xU(1) gauge symmetries of the Standard Model arise naturally without additional assumptions. Finally, the solution is consistent only with 3+1 spacetime dimensions, as it encounters obstructions in all other dimensional configurations. This framework integrates quantum mechanics, relativistic quantum mechanics, quantum gravity, spacetime dimensionality, and particle physics gauge symmetries from a simple entropy maximization problem constrained by a vanishing phase, yielding the most parsimonious formulation of fundamental physics to date.
Explaining Misinformation Detection Using Large Language Models
Authors: Pendyala Vishnu S , Hall Eliot Christopher
Published: May 2024

LLMs are a compressed repository of a vast corpus of valuable information on which they are trained. Therefore, this work hypothesizes that LLMs such as Llama, Orca, Falcon, and Mistral can be used for misinformation detection by making them cross-check new information with the repository on which they are trained. Accordingly, this paper describes the findings from the investigation of the abilities of LLMs in detecting misinformation on multiple datasets. The results are interpreted using explainable AI techniques such as LIME, SHAP, and Integrated Gradients. The LLMs themselves are also asked to explain their classification. These complementary approaches aid in better understanding the inner workings of misinformation detection using LLMs and lead to conclusions about their effectiveness at the task.
Is the Myasthenia Gravis (MG) the Result of Age and Sex/Gender? A Narrative Review for Identifying Genetic and Epigenetic Biomarkers for a Differential MG Management in Old and Young Women
Authors: Schirò Giuseppe , Colletti Tiziana , piccoli tommaso , ragonese paolo , salemi giuseppe , Balistreri Carmela Rita , d'amelio marco
Published: May 2024

Myasthenia gravis (MG) is a disease characterized by typical clinical and immunopathogenic pe-culiarities, which correlate with age and sex/gender. Accordingly, MG patients show thymic al-terations and auto-antibodies productions, that can be the expression of a different pathogenetic mechanism related to age and gender. This determines, in relation to age at and sex/gender, a dif-ferent MG onset, prognosis, and outcome. Therefore, diverse MG forms can be identified, classi-fied, and characterized in relation to their different features, and precisely there are early onset and late-onset forms of MG. It has been hypothesized that the cause of appearance the two diverse forms of MG can be ascribed mainly to the diverse genetic and epigenetic factors. In this narrative review, we will analyze and discuss about the interplay of age- and sex-related factors (i.e. genet-ic and epigenetic factors) related to two different MG forms and how they contribute to their di-verse pathogenesis.
Numerical Approach on Collatz Conjecture
Authors: Lee Youngik
Published: May 2024

We can analyze the properties of the Collatz Conjecture by using Terras’ Theorem, and computational graphical calculations. To do this, we introduce the concept of “tree" which shows the relationship between the input and output positive integers of the Collatz process. This approach offers a novel way for determining the non-existence of loops and diverge trees through computer simulations.
Conceptualizing Scaffold Guided Breast Tissue Regeneration in a Preclinical Large Animal Model
Authors: Cheng Matthew , Janzekovic Jan , Finze Ronja , Mohseni Mina , Saifzadeh Siamak , Ung Owen , Wagels Michael , Hutmacher Dietmar W
Published: May 2024

Scaffold guided breast tissue regeneration (SGBTR) can both transform reconstructive and cosmetic breast surgery. Implant-based surgery is the most common method. However, there are inherent limitations as there is replacement of tissue rather than regeneration. Regenerating autologous soft tissue has the potential to provide a more like-for-like reconstruction with minimal morbidity. Our SGBTR approach regenerates soft tissue by implanting additively manufactured bioresorbable scaffolds filled with autologous fat graft. A pre-clinical large animal study was conducted implanting 100 ml breast scaffolds (n=55) made from medical-grade polycaprolactone in 11 minipigs for 12 months. Various treatment groups were investigated where immediate or delayed autologous fat graft, as well as platelet rich plasma were added to scaffolds. Computed Tomography and Magnetic Resonance Imaging was performed on explanted scaffolds to determine volume and distribution of regenerated tissue. Histological analysis was performed to confirm tissue type. At 12 months we were able to regenerate and sustain a mean soft tissue volume of 60.9 4.5 ml (95% CI) across all treatment groups. There was no evidence of capsule formation. There were no immediate or long-term post-operative complications. In conclusion, we were able to regenerate clinically relevant soft tissue volumes utilizing SGBTR in a pre-clinical large animal model.
East Meets the West: Influence of Chinese and the Western Values in Hong Kong New Senior Secondary Curriculum
Authors: Hui Emily Sein Yue Elim
Published: May 2024

After the end of colonial rule in 1997, the Hong Kong education system has been experiencing a policy reform on Senior Secondary Education (NSS) Curriculum commenced in September 2009 aiming to educate students as globalized Hong Kong citizens for the Western. Although previous scholars argued that it is hard to differentiate between domestic values and the Western values in account of curriculum development (Sewpaul, 2007), this study demonstrates an analysis using the dichotomy to investigate how local curriculum, especially in the post-colonial areas, embrace both the Western values and domestic values. Using content analysis on the NSS curriculum guides, this article evaluates the influence of the Western values and Chinese values in the NSS curriculum through investigating: (1) how the Western values and Chinese values was incorporated into the curriculum throughout its development (2) why some values are more significantly highlighted in the curriculum guide. Findings include that more Chinese values are involved in the curriculum documents. This may be because of the upholding of domestic values as a post-colonial city. The Western values which are academically related are greatly incorporated into the local curriculum.
Advances in Nanoparticle-Enhanced Vaccine Strategies: Towards a Universal Protection Against Influenza B Viruses
Authors: Row Shounak , Kondhare Kunal
Published: May 2024

Influenza viruses pose a continuing public health challenge due to their high mutation rate and the need for annual vaccine updates. A recent advancement in nanoparticle-based vaccine technology for developing a universal influenza vaccine. We focused on four key studies investigating the use of lipid nanoparticles (LNPs), nanoparticle immunogens, and multivalent epitope-based nanoparticles. The studies demonstrated promising results. The single-dose mRNA -LNP vaccine targeting five influenza B virus antigens effectively protected mice from a broad range of strain. Additionally, nanoparticle immunogens designed to display multiple influenza virus strains induced broad protective immunity in mice. Furthermore, LNPs enhanced the efficacy of mRNA and protein subunit vaccines by stimulating robust T follicular helper cell and humoral responses. Finally, an intranasal multivalent epitope-based nanoparticle vaccine offered broad protection against diverse influenza viruses. These findings highlight the potential of nanoparticle-based approaches for developing a universal influenza vaccine that offers long-lasting and broad-spectrum protection. Further research is needed to evaluate the safety and efficacy of these novel vaccines in humans.
An Assessment of Semaglutide Safety Based on Real World Data: From Popularity to Spontaneous Reporting in EudraVigilance Database
Authors: Butuca Anca , Dobrea Carmen Maximiliana , Arseniu Anca Maria , Frum Adina , Chis Adriana Aurelia , Rus Luca Liviu , Ghibu Steliana , Juncan Anca Maria , Muntean Andrei Catalin , Lazăr Antonina Evelina , Gligor Felicia Gabriela , Morgovan Claudiu , Vonica-Tincu Andreea Loredana
Published: May 2024

Some glucagon-like peptide-1 receptor agonists (GLP-1 RAs), first used in the treat-ment of type 2 diabetes mellitus (T2DM), have been approved for the treatment of obe-sity in patients with or without T2DM (liraglutide – LIR, semaglutide - SEM, and tir-zepatide - TIR). Social media had an important influence on the off-label use of GLP-1 RAs for obesity, especially for SEM. We analysed the Google queries related to SEM to assess people's interest in this drug. We also investigated the occurrence of adverse drug reactions (ADRs) by searching the EudraVigilance database (EV) for Individual Case Safety Reports (ICSRs) that reported SEM as the suspected drug and performed a descriptive and a disproportionality analysis. Data obtained for SEM were compared to other GLP-1 RAs. SEM had the highest proportions of searches on Google associated with the term “weight loss” and presented the lowest number of severe ADRs, but it also had the highest number of ICSRs reported in EV. Even though no unexpected safety issues have been reported for it until now, SEM has a high tendency for overdose reports. The most frequent off-label use was reported for SEM and TIR. In order to lower the ADRs’ risks, the off-label use should be reduced and carefully monitored.