bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Long Noncoding RNA HOXA-AS2 on the Proliferation and Migration of Gallbladder Cancer Cells
Authors: Zhang Peng , Liu Luhao , Zhang Weiting , Fang Jiali , Li Guanghui , Zhang Lei , Li Jiali , Deng Xuanying , Ma Junjie , Li Kun , Chen Zheng
Published: October 2022

To explore the function and mechanism of lncRNA HOXA-AS2 in cancer-associated fibroblasts (CAFs)-derived exosomes in gallbladder cancer metastasis, and provide new research targets for the treatment of gallbladder cancer. At the same time, in order to clarify the early predictive value of lncRNA HOXA-AS2 for gallbladder cancer metastasis, and to provide a theoretical basis for clinical individualized treatment of gallbladder cancer. Methods. In our previous work, we used TCGA database analysis to find that lncRNA HOXA-AS2 was highly expressed in gallbladder cancer tissues compared with normal tissues. In this study, the expression levels of HOXA-AS2 in gallbladder cancer cell lines and control cells were first verified by QPCR and Western blot methods. Then, lentiviral tools were used to construct knockdown vectors (RNAi#1, RNAi#2) and negative control vectors targeting two different sites of HOXA-AS2, and the vectors were transfected into NOZ and OCUG-1 cells, respectively. Real-time PCR was used to detect knockdown efficiency. Then, the effects of silencing HOXA-AS2 on the proliferation, cell viability, cell migration, and invasion ability of gallbladder cancer cells were detected by MTT, plate cloning assay, Transwell migration chamber assay, and Transwell invasion chamber assay. Finally, the interaction between HOXA-AS2 and miR-6867 and the 3

′

UTR of YAP1 protein was detected by luciferase reporter gene. The results showed that the expression level of HOXA-AS2 in gallbladder cancer cell lines was higher than that in control cells. The expression of HOXA-AS2 in gallbladder carcinoma tissues was significantly higher than that in adjacent tissues (

p
<
0.05

). After successful knockout of HOXA-AS2 by lentiviral transfection, the expression of HOXA-AS2 in gallbladder cancer cell lines was significantly decreased. Through cell proliferation and plate clone detection, it was found that silencing HOXA-AS2 inhibited cell proliferation and invasion. Through software prediction and fluorescein reporter gene detection, it was found that HOXA-AS2 has a binding site with miR-6867, and the two are negatively correlated, that is, the expression of miR-6867 is enhanced after the expression of HOXA-AS2 is downregulated. And the 3

′

UTR of YAP1 protein in the Hippo signaling pathway binds to miR-6867. Therefore, HOXA-AS2 may affect the expression of YAP1 protein by regulating miR-6867, thereby inhibiting the Hippo signaling pathway and promoting the proliferation and metastasis of gallbladder cancer cells. HOXA-AS2 is abnormally expressed in gallbladder cancer cells. HOXA-AS2 may promote the migration and invasion of gallbladder cancer cells by regulating the Hippo signaling pathway through miR-6867. HOXA-AS2 may serve as a potential diagnostic and therapeutic target for gallbladder cancer in clinic.
Correlation of Complex Impacted Mandibular Teeth with Pericoronitis and Effect of Minimally Invasive Tooth Extraction on Patients’ Long-term Outcome of Masticatory Ability
Authors: Nie Tinghong , Chang Bojie , Tian Lili , Cao Shansong , Wang Junjie , Qi Haitao , Gao Lirong
Published: October 2022

Objective. To explore the correlation of complex impacted mandibular teeth and pericoronitis, as well as the effect of minimally invasive tooth extraction on patients’ long-term outcomes of masticatory ability. Methods. A total of 101 patients with complex impacted teeth who were treated in our hospital from March 2019 to June 2021 were selected and divided into the control group (n = 55) and the observation group (n = 46) according to the different treatment methods. The patients in the control group were given conventional extraction treatment, and the patients in the observation group were given minimally invasive extraction treatment. The clinicopathological features of patients complicated by pericoronitis were observed and the relationship between complex impacted mandibular teeth and pericoronitis was discussed. Additionally, we made statistics on operative time (OT), intraoperative blood loss (IBL), dental socket integrity score, and adverse reactions (ARs) and compared the clinical efficacy between the observation group and control group. The Visual Analogue Scale (VAS) and Oral Health Impact Profile scale (OHIP-14) were utilized for pain assessment and oral health status evaluation, respectively. Bite force (BF) and masticatory efficiency were also measured. Results. OG showed less OT and IBL than CG, with a higher dental socket integrity score (

P
<
0.05

). In addition, OG outperformed CG with a higher overall response rate and a lower incidence of ARs (

P
<
0.05

). The pretreatment VAS score, mouth-opening degree, and OHIP-14 score differed insignificantly between groups (

P
>
0.05

). After treatment, the VAS score of OG decreased, while the mouth-opening degree and OHIP-14 score increased (

P
<
0.05

). Finally, the mastication ability was higher in OG at 7 days postoperatively, but there was no difference between groups at 6 months postoperatively (

P
>
0.05

). Conclusion. Complex mandibular impacted teeth can easily induce pericoronitis, so clinicians should pay attention to the influencing factors of pericoronitis. Minimally invasive surgery for complex impacted mandibular teeth can effectively improve treatment outcomes, accelerate patient rehabilitation, and provide more effective protection for patients’ oral health and masticatory ability, which is worth promoting in clinical use.
Guiding and Leakage Dispersion Characteristic of TM01Mode in a Circular Dielectric Rod
Authors: Kelebekler Ersoy
Published: October 2022

Open dielectric waveguide structures such as circular dielectric rods can be used as antennas by leaking energy in the transverse direction or as guiding structures with low loss in integrated circuits at different frequency ranges. It is essential to understand electromagnetic wave behavior in different frequency regions such as reactive mode region, leaky-wave or antenna mode region, and guided mode region. In this study, it is aimed to assimilate the electromagnetic phenomenon for open dielectric structure by showing the overlapping between the analytic solutions and the simulation results of the TM01 mode of the circular dielectric rod. The analytic solutions for leaky-wave modes have been obtained using the coefficients matrix of the system of characteristic equations of the structure and Davidenko’s method. The field distributions and the scattering parameters have been obtained in CST microwave studio software. The outcomes obtained in the study presented the overlapping between the analytical results and the simulations. The simulation results show the leakage starts end of the reactive mode region where the electromagnetic energy reflects to the feed line, and the electromagnetic energy leaks at the leaky-wave/antenna mode region, and the leakage decreases at the guided mode region as much as it can be neglected while the frequency increases.
Use of Point-of-Care Ultrasound for Early Identification of Acute Aortic Root Dissection
Authors: Thomas Kristina , Amr Omar
Published: October 2022

Point-of-care ultrasound (POCUS) is becoming a frequently utilized imaging tool in the emergency department (ED) as it can aid in early diagnosis of many pathologies. This is a case report of a 55-year-old male who presented to the emergency department by ambulance for sudden onset chest pain followed by a syncopal episode. Point-of-care echocardiogram revealed a large pericardial effusion with a significantly dilated aortic root, concerning for aortic dissection. Patient was emergently taken for a computed tomography (CT) scan, which was only remarkable for an ascending thoracic aortic aneurysm but failed to show an aortic dissection flap. On repeat POCUS, a dissection intimal flap, large pericardial effusion with tamponade physiology, and aortic regurgitation were identified and later confirmed on transesophageal echocardiogram. This case report details a rare pathology that was correctly identified on initial POCUS before it was seen on CT scan.
A Medical Resident with a History of Alcohol Abuse and Suicidal Ideation: A Challenge for Both Psychiatry and Occupational Medicine in the Context of the First Wave of the COVID-19 Pandemic
Authors: Corsi Martina , Veltri Antonello , Perretta Salvio , Marino Riccardo , Necciari Gabriele , Caldi Fabrizio , Foddis Rudy , Cristaudo Alfonso , Buselli Rodolfo , Guglielmi Giovanni
Published: October 2022

This case study draws attention to the hazards of physicians with a history of alcohol addiction and a particular psychopathology framework in the context of occupational health surveillance, particularly during the challenging working conditions brought about by the COVID-19 pandemic. The case involves a hospital resident in her thirties, with a previous history of addiction and attempts at suicide, who was assigned to a COVID-19 unit of an Italian hospital. In this case study, we discuss the preventive intervention put in place in order to protect physicians’ health and work. What emerges is the key role that rapid substantive communications between specialists play in formulating an effective strategy for dealing with these conditions. We believe this case is noteworthy for the lessons that can be learned for tailoring prevention and treatment pathways for health care workers with addiction.
Acceleration of Deep Neural Network Training Using Field Programmable Gate Arrays
Authors: Tufa Guta Tesema , Andargie Fitsum Assamnew , Bijalwan Anchit
Published: October 2022

Convolutional neural network (CNN) training often necessitates a considerable amount of computational resources. In recent years, several studies have proposed for CNN inference and training accelerators in which the FPGAs have previously demonstrated good performance and energy efficiency. To speed up the processing, CNN requires additional computational resources such as memory bandwidth, a FPGA platform resource usage, time, power consumption, and large datasets for training. They are constrained by the requirement for improved hardware acceleration to support scalability beyond existing data and model sizes. This paper proposes a procedure for energy efficient CNN training in collaboration with an FPGA-based accelerator. We employed optimizations such as quantization, which is a common model compression technique, to speed up the CNN training process. Additionally, a gradient accumulation buffer is used to ensure maximum operating efficiency while maintaining gradient descent of the learning algorithm. To validate the design, we implemented the AlexNet and VGG-16 models on an FPGA board and laptop CPU along side GPU. It achieves 203.75 GOPS on Terasic DE1 SoC with the AlexNet model and 196.50 GOPS with the VGG-16 model on Terasic DE-SoC. Our result also exhibits that the FPGA accelerators are more energy efficient than other platforms.
Research on the Correlation of Peripheral Blood Inflammatory Markers with PCT, CRP, and PCIS in Infants with Community-Acquired Pneumonia
Authors: Li Linwei , Miao Hongyun , Chen Xue , Yang Shengjie , Yan Xiaoyong
Published: October 2022

Aims. This study aimsto investigate the relationship between peripheral blood neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), systemic immune-inflammatory index (SII), and procalcitonin (PCT), C-reactive protein (CRP), and pediatric critical illness score (PCIS) in infants with community-acquired pneumonia (CAP). Methods. 100 infants with bacterial CAP admitted to our hospital between January 2021 and December 2021 were selected as the infected group, and another 100 healthy infants who underwent health check-ups at the same time were selected as the control group, and the NLR, PLR, and SII of peripheral blood of infants in both groups and the serum PCT, CRP, and PCIS scores of infants in the infected group were tested. The correlation between NLR, PLR, SII, and PCT, CRP, and PCIS was analyzed by Spearman’s analysis. Results. The peripheral blood levels of NLR, PLR, and SII were higher in the infected group than in the control infants (

P
<
0.05

). The ROC results showed that the AUCs of peripheral blood NLR, PLR, and SII for the diagnosis of infants with CAP were 0.934, 0.737, and 0.882, respectively. The ROC results showed that the AUCs of peripheral blood NLR, PLR, and SII for assessing the extent of disease in infants with CAP were 0.815, 0.710, and 0.813, respectively, with best cut-off values of 2.05, 98.57, and 823.41; the joint predicted AUC was 0.862. Conclusions. NLR, PLR, and SII were significantly elevated in the peripheral blood of infants with CAP, positively correlated with PCT and CRP, and negatively correlated with PSIC scores, and NLR and SII also have some guiding value in early diagnosis and assessment of the extent of the disease in infants and toddlers with CAP.
Cross-Context Accurate English Translation Method Based on the Machine Learning Model
Authors: Zhang Qiang
Published: October 2022

The era of big data and cloud computing has come, communication between different languages is becoming more and more common, and the barriers between languages are becoming more and more prominent. As the most important means to overcome language barriers, machine translation will play an increasingly important role in modern society. The previous machine translation technology has more or less disadvantages. The accuracy of translation is too low, which is a huge bottleneck hindering the further development of machine translation technology. Therefore, based on this, we can consider modeling the cross-context accurate English translation model based on the machine translation model and rely on the working principle of machine learning. This experiment shows that the translation accuracy of our method reaches 94.2%, which is higher than 39.5% of the benchmark method. This shows that the method in this paper can reduce the influence of other factors, ensure the accuracy of cross-context English translation to a certain extent, and meet the performance improvement requirements of the English translation system.
Full Mouth Rehabilitation Using Telescopic Removable Prosthesis
Authors: Alhammadi Sara Hussain
Published: October 2022

A female, aged 55 years, was presented to the clinic concerned with her inability to function properly due to missing teeth and collapse of her vertical dimension. On examination, remaining tooth position of the upper arch was favorable for telescopic denture and remaining tooth position of the lower arch was favorable for removable prosthesis. The patient requested an aesthetic maxillary and mandibular denture with no visible metal clasps on smiling. Therefore, upper telescopic removable complete denture and lower chrome cobalt removable prostheses were suggested to the patient as conservative treatment to reestablish her occlusal vertical dimension and restore her aesthetics and function.
Urinary RBP as an Independent Predictor of Renal Outcome in Diabetic Nephropathy
Authors: Cai Fanghao , Zhang Li , Zhao Peng , Qiu Fengping , Mukhtar Abdullahi Mohamed , Ma Yanhong , Chen Jianghua , Han Fei
Published: October 2022

Background. Renal tubular impairment is prevalent in diabetic nephropathy (DN) and the histological severity predicted renal outcome. Biomarkers of tubular injury also increased in the urine of DN patients. The retrospective study aimed to assess the prognostic value of clinically widely applied urinary tubular injury markers, retinol-binding protein (RBP), β2-microglobulin (β2-MG) and N-acetyl-β-D-glucosaminidase (NAG) in DN. Method. A total of 305 patients with biopsy-proven DN were enrolled. The baseline urine total protein and components including albumin, IgG, RBP, β2-MG and NAG were retrieved from medical records. The primary outcome was end stage renal disease (ESRD). Cox proportional hazard analysis and restricted cubic splines were performed to evaluate the association of parameters with ESRD. Nomograms were constructed and concordance index (C-index) was used to measure the prediction ability. Result. The levels of urinary RBP, β2-MG and NAG were positively correlated with the severity of interstitial fibrosis and tubular atrophy (IFTA). Positive correlations were also observed among β2-MG, NAG and mesangial expansion. Urinary RBP was not correlated with any glomerular lesions. Urinary RBP, β2-MG and NAG were risk factors for ESRD in hazard analysis with adjustment for age, gender and body mass index (BMI). The hazard ratios increased with the increment of baseline levels. In the multivariate Cox model including serum creatinine (SCr), total urinary protein, urinary albumin, urinary IgG and the tubular injury biomarkers, urinary RBP (with every g/mol.Cr increase: HR 1.06, 95% CI 1.03-1.10, p =0.001) remained as an independent risk factor for ESRD in DN patients. Patients were divided by the medium value of urinary RBP into the low RBP and high RBP groups. Survival analysis showed that significantly more patients in the high RBP progressed to ESRD compared to those in the low RBP group (p =0.02) when urinary total protein was less than 3.5 g/g. The C-index of the nomogram incorporating age, gender, BMI, SCr and total urine protein was 0.757. The value increased to 0.777 after adding urinary RBP to the model. Conclusions. Urinary RBP excretion was only correlated with the severity of IFTA and independently predicted ESRD in DN patients.
Creating MHC-Restricted Neoantigens with Covalent Inhibitors That Can Be Targeted by Immune Therapy
Authors: Hattori Takamitsu , Maso Lorenzo , Araki Kiyomi Y. , Koide Akiko , Hayman James , Akkapeddi Padma , Bang Injin , Neel Benjamin G. , Koide Shohei
Published: October 2022

Intracellular oncoproteins can be inhibited with targeted therapy, but responses are not durable. Immune therapies can be curative, but most oncogene-driven tumors are unresponsive to these agents. Fragments of intracellular oncoproteins can act as neoantigens presented by the major histocompatibility complex (MHC), but recognizing minimal differences between oncoproteins and their normal counterparts is challenging. We have established a platform technology that exploits hapten–peptide conjugates generated by covalent inhibitors to create distinct neoantigens that selectively mark cancer cells. Using the FDA-approved covalent inhibitors sotorasib and osimertinib, we developed “HapImmune” antibodies that bind to drug–peptide conjugate/MHC complexes but not to the free drugs. A HapImmune-based bispecific T-cell engager selectively and potently kills sotorasib-resistant lung cancer cells upon sotorasib treatment. Notably, it is effective against KRASG12C-mutant cells with different HLA supertypes, HLA-A*02 and A*03/11, suggesting loosening of MHC restriction. Our strategy creates targetable neoantigens by design, unifying targeted and immune therapies.

Significance:

Targeted therapies against oncoproteins often have dramatic initial efficacy but lack durability. Immunotherapies can be curative, yet most tumors fail to respond. We developed a generalizable technology platform that exploits hapten–peptides generated by covalent inhibitors as neoantigens presented on MHC to enable engineered antibodies to selectively kill drug-resistant cancer cells.

See related commentary by Cox et al., p. 19.

This article is highlighted in the In This Issue feature, p. 1
Alcohol Consumption Post-Liver Transplantation: A Cross-Sectional Study
Authors: Chálim Rebelo Carolina , Félix Catarina , Cardoso Filipe S. , Bagulho Luis , Sousa Monica , Mendes Milena , Glória Helena , Mateus Élia , Mega Inês , Jara Miguel , Pinto Marques Hugo , Nolasco Fernando , Martins Américo , Perdigoto Rui
Published: October 2022

Background: Listing patients with alcohol-associated liver disease (ALD) for liver transplant (LT) remains challenging especially due to the risk of alcohol resumption post-LT. We aimed to evaluate post-LT alcohol consumption at a Portuguese transplant center. Methods: We conducted a cross-sectional study including LT recipients from 2019 at Curry Cabral Hospital, Lisbon, Portugal. A pretested survey and a validated Portuguese translation of the Alcohol Use Disorder Identification Test (AUDIT) were applied via a telephone call. Alcohol consumption was defined by patients’ self-reports or a positive AUDIT. Results: In 2019, 122 patients underwent LT, and 99 patients answered the survey (June 2021). The mean (SD) age was 57 (10) years, 70 patients (70.7%) were males, and 49 (49.5%) underwent ALD-related LT. During a median (IQR) follow-up of 24 (20–26) months post-index LT, 22 (22.2%) recipients consumed any amount of alcohol: 14 had a drink monthly or less and 8 drank 2–4 times/month. On drinking days, 18 patients usually consumed 1–2 drinks and the remainder no more than 3–4 drinks. One patient reported having drunk ≥6 drinks on one occasion. All post-LT drinking recipients were considered low risk (score <8) as per the AUDIT score (median [IQR] of 1 [1–2]). No patient reported alcohol-related problems, whether self-inflicted or toward others. Drinking recipients were younger (53 vs. 59 years, p = 0.020), had more non-ALD-related LT (72.7 vs. 44.2%, p = 0.018) and active smoking (31.8 vs. 10.4%, p = 0.037) than abstinent ones. Conclusion: In our cohort, about a quarter of LT recipients consumed alcohol early posttransplant, all with a low-risk pattern according to the AUDIT score.
Assessment on knowledge and perception regarding health risks of pesticide usage among farmers
Authors: Anbazhagan Priyanka , Wilson Alby Anna , Nallasamy Venkateswaramurthy , Ramanathan Sambathkumar
Published: October 2022

Globally, pesticides are essential substances that have significant importance in increasing food production and pest management. Although, the serious concern about the health risk of pesticide toxicity should be investigated. The aim of the study is to assess the knowledge and perception of health risks of pesticide usage among farmers. This online-based descriptive cross-sectional study was conducted among farmers in Namakkal district, Tamil Nadu, India. A validated questionnaire was prepared, assessing the sociodemographic and analyzing the level of awareness, perception of pesticide usage among farmers. There were 412 farmers participated, in which 98.5% use pesticides and among them, 72.4% of farmers do not use personal protective equipment (PPE) on pesticide application. Hence, 68% are not aware of the harmful effects of pesticides even though 94.5% experienced health related problems while using them. Therefore, 95.4% of farmers think it is necessary to create awareness about safe handling practices and health risks regarding the usage of pesticides. Our study revealed that farmers do not have adequate knowledge about safe pesticide handling and are not aware of pesticide toxicity levels along with the risk associated with the degree of toxicity which is essential for implementing strategies regarding pesticide safety education and training.
The burden of depression and malnutrition in the elderly population of Western Rajasthan
Authors: Upadhyay Shikha , Mantri Neha , Joshi Nitin Kumar , Goel Akhil Dhanesh , Kumar Nitesh , Gupta Manoj Kumar , Bhardwaj Pankaj , Singh Kuldeep
Published: October 2022

With changing demography, developing countries will be outnumbered by the elderly and their associated chronic diseases. The geriatric population is at increased risk of malnutrition with multiple factors, especially depression. This study explored potential linkages between malnutrition and depression in the geriatric population. A cross-sectional study was conducted at tertiary healthcare facilities at Western Rajasthan, India from April to June 2018. After consent from 310 elderly patients attending out patient department, a pre-tested questionnaire was used to collect data. Assessment of malnutrition status using mini nutritional assessment (MNA), depression using geriatric depression scale (GDS), physical frailty using activities of daily living (ADL), and instrumental activities of daily living (IADL) was done. Chi-square, Fischer test, and unpaired t-test were employed for inferential statistics. Multiple logistic regression was used to compute the adjusted odds ratio. Out of 310 elderlies, 192 (61.9%) participants were categorized as having poor nutrition and 99 (31.9%) were likely to suffer from depression. The elderly at risk of malnutrition among depressed was 75.8% (n=99) with a preponderance for females, and minor disabilities. Multivariate analysis suggested higher odds of malnutrition in the elderly with lower socioeconomic status and rural residence. Depression and malnutrition are linked in a destructive cycle but the causality remains elusive.
Menstrual hygiene among early adolescent girls and its’ related factors
Authors: Ritanti Ritanti , Wahyuni Tri
Published: October 2022

This study aimed to determine the prevalence of menstrual hygiene and the association between mother’s role function and menstrual hygiene among early adolescent girls. This cross-sectional study used a simple random sampling technique. The target population including early adolescent girls aged 12-15 years old, had menarche. Hence, 367 respondents in this study passed the analysis's inclusion criteria. Multivariable logistic regression was used to determine the association. There were 46.32 % of respondents noticed the prevalence of good menstrual hygiene. There were 170 out of 367 respondents who reported the presence of good menstrual hygiene. The ultimate model of a multiple logistic regression designated that mother and information exposure support (adj. OR=6.89, 95% CI: 3.84–12.38, p<0.001; adj. OR=2.17, 95% CI: 1.36–3.45, p=0.001) were meaningfully linked by the bad menstrual hygiene. Other significant covariate factors were organization (adj. OR=1.79, 95% CI: 1.10–2.91, p=0.018). The study found a high prevalence of good menstrual hygiene. Mother support, information exposure, and organization were linked with menstrual hygiene among early adolescent girls. 
The use of Sansevieria sp. and Cymbopogon nardus extracts on humidifier modification to reduce airborne germs
Authors: Rachmaniyah Rachmaniyah , Rusmiati Rusmiati , Khambali Khambali
Published: October 2022

A humidifier including natural components such as mother-in-tongue law's (Sansevieria sp.) and lemongrass (Cymbopogon nardus) extracts is required to control room air quality. The purpose of this study was to assess the chemical composition and anti-fungal and anti-germ capability of Sansevieria sp. and Cymbopogon nardus in a room. The experimental method and One Group Pre-test Post-test Design were utilized in this investigation. To minimize airborne germs, Sansevieria sp. and Cymbopogon nardus extract were used as humidifier modification materials in this case. Concentrations of Sansevieria sp extract of 30%, 40%, and 50% were made available. The data was analyzed using Anovatest.The Anova test results showed that the Sansevieria sp. extracts with concentrations of 30%, 40%, and 50% had p-values greater than 0.05. It signifies that there was no significant or insignificant difference in the concentrations used, hence the extracts of Sansevieria sp and Cymbopogon nardus extracts had the same effective antibacterial potential in this investigation. It was determined that Sansevieria sp and Cymbopogon nardus extract as modified humidifier solution at concentrations of 30%, 40%, and 50% have the same efficacy in decreasing Germ in the room air.
Psychological impact of parent-adolescent communication: A critical analysis
Authors: V Raja Mohan Shanthi Bavani , Dhanapal Saroja , Govindasamy Vimala , Purushothaman Pillay Kirthikaa Sydney
Published: October 2022

Parent-adolescent relationship is an essential part of growing up and it is the key determinant of adolescents’ personality development. Their relationship with their families at this stage determines their character. Studies show there is a significant relationship between parent-adolescents’ communication and adolescents’ psychological well-being. However, the findings are not conclusive. The current quantitative research assessed the level of parent-adolescent communication on adolescents’ self-esteem and perceived stress. Data was collected among 377 Malaysians aged 12 to 17. The ‘parent-adolescent relationship questionnaire’ (PARQ), ‘rosenberg self-esteem scale’ and ‘perceived stress scale-10’ (PSS) were used. The results show that there is a positive correlation between parent adolescent communication and self-esteem r (350) =.390, p=.000 and a negative correlation between self-esteem and level of stress perceived among adolescents at r (350)=-.103, p=.054. The level of correlation shows a more positive relationship between parent adolescent communication, and self-esteem whereas the level of self-esteem does not immensely affect the stress level of these adolescents. Further, it was proven that female adolescents had lower self-esteem and higher stress compared to male adolescents. The study recommends that parents should cultivate good parent-adolescent communication to ensure positive psychological impact on their adolescents.
Job satisfaction among primary health care nurses
Authors: Soesanto Edy , Yanto Arief , Irani Ninin , Pranata Satriya , Rejeki Sri , Sasmito Priyo
Published: October 2022

This study aimed to analyze the job satisfaction of nurses in primary health care facilities. This study employed a quantitative descriptive design. The research used a cross-sectional approach. This study involved 226 nurses who worked in 15 inpatients primary health care. The sampling technique uses a proportionate simple random sampling technique. Nurse job satisfaction instruments assessed context factors and content factors. Nurse job satisfaction on context factor was in a good category by a big responsibility for nurse's work (55.2%), progress in work developed well (63.4%), nurses had the opportunity to achieve achievement (54.5%), nurses got great recognition for performance (58.6%) and felt their work is valuable (65.5%). Job satisfaction was supported by policy indicators, supervision, salary, interpersonal relationships, and good working conditions. On the other hand, nurses' job satisfaction on the content factor still needs to be optimized. This is supported by the job satisfaction of nurses on the indicators of responsibility, achievement, performance recognition that has not reached 60%. Therefore, job satisfaction among nurses in inpatient primary health care was quite good enough but still requires optimization on the content factor.
Depression, anxiety, and physical activity among antenatal women during COVID-19 pandemic
Authors: Arifin Siti Roshaidai Mohd , Zulkifli Seri Wardah , Abang Abdullah Khadijah Hasanah , Syed Mohideen Fathima Begum , Hidayah Abas Nurul Ain , Perveen Asma , Husain Rohayah , Mat Khairi Che , Abd Aziz Karimah Hanim , Aidid Edre Mohamad , Musa Ramli , Idris Izazol
Published: October 2022

The prevalence of mental health problems among antenatal women has escalated during the COVID-19 pandemic compared to the pre-pandemic period. Physical activity palys role to reduce depression and anxiety, which required to be studied further. This study aimed to assess the association between physical activity with depression and anxiety among antenatal women during the COVID-19 pandemic. This cross-sectional study applied convenience sampling to recruit 544 antenatal women from March to June 2021. Questionnaires including the Edinburgh postnatal depression scale (EPDS), state-trait anxiety inventory (STAI), and pregnancy physical activity questionnaire (PPAQ) were distributed via social media to determine the prevalence of depression, anxiety, and physical activity level. Data were analysed using descriptive statistics, chi-square, mann-whitney, and kruskal wallis tests. Out of 544 antenatal women, 24.1% of them had depressive symptoms and 82.4% had anxiety. Only 12.1% of the women were sufficiently active during the pandemic. There was no association between physical activity, depression, and anxiety. The high prevalence of depression and anxiety during the COVID-19 pandemic among Malaysian antenatal women underscores the urgent need for addressing this public health burden. Interventions to alleviate the symptoms should include strategies beyond physical activity, for example, a mobile application or telephone-delivered social support that is made easily accessible throughout the pandemic.
Impact of socioeconomic change and hygiene sanitation during pandemic COVID-19 towards stunting
Authors: Arini Diyah , Ernawati Dwi , Hayudanti Dewinta , Alristina Arie Dwi
Published: October 2022

The global COVID-19 pandemic has raised the risk of malnutrition in children under five years, including stunting. Stunting is common in low-income regions, when families cannot afford nutritious meals. Stunting may become more common as a result of changes in family socioeconomic circumstances, personal cleanliness, and environmental sanitation during the pandemic. This study determined the effect of socioeconomic factors and hygiene sanitation during COVID-19 pandemic on the incidence of stunting in coastal areas. This was analytical survey research with cross sectional approach. The total sample was 3886 families who had toddlers aged 0-59 months in the coastal areas in Surabaya City, Indonesia. The study found that low family income, hand-washing habits, clean water sources, sewer access, waste management, and healthy latrine have significant impact to malnutrition, especially stunting.
Larval survey of the dengue-endemic area in Samarinda: guide to determine risk containers
Authors: Ridha Muhammad Rasyid , Sulasmi Sri
Published: October 2022

Dengue has been reported in Indonesia since1968; the cases tend to increase and spread every year. From 2015-2019 almost all districts in Indonesia had dengue cases. This study aimed to determine the value of the entomological index and its relationship with the treatment of various types of containers and spatial epidemiology. A larval survey was conducted to determine the presence of larvae in water containers. Logistic regression and spatial data analysis were performed to see the distribution and make a buffer area map of Aedes sp. spreading risk. The types of containers observed in this study were water tubs, drums, buckets, refrigerator containers, dispenser containers, and other categories. There were 221 containers found containing Aedes sp. larvae. Container types affected the presence of larvae with adjusted ORs of 2.779 (95% CI: 1.441-5.360) on buckets, 9.812 (95% CI: 1.249-77.051) on refrigerator holders, and 0.301 (95% CI: 0.147-0.617) on dispenser holders, while the other variables were constant. The spatial analysis found that many houses are at risk of dengue transmission within a radius of 100 m. The discovery of containers as potential breeding sites for Aedes sp. provides a chance for an increase in dengue cases in Samarinda.
Development and validation of a functional health literacy instrument in the Philippines
Authors: Tolabing Ma. Carmen C. , Co Kim Carmela D. , Mamangon Martin Aaron M.
Published: October 2022

Functional health literacy (FHL) involves skills in writing, reading, oral expression, comprehension, and numerical calculations to successfully function and complete health-related tasks. This study aimed to develop and validate an instrument for measuring FHL in the Philippines using a mixed-method design. FHL-5TEST is an instrument consisting of five questions developed in consultation with local experts, translated to major Philippine languages, and underwent translation analysis, pretesting, cultural adaptation, and validation. A cross-sectional study was conducted in a random sample of 15-70-year-old Filipino residents to validate the instrument. The FHL-5TEST demonstrated high internal consistency, with a Cronbach’s alpha of 0.7690. Across different cut-off values, the sensitivity and specificity of the instrument in detecting limited FHL ranged from 60.9% to 86.0% and from 61.6% to 97.2%, respectively. The study demonstrated that the FHL-5TEST is a valid and reliable instrument to measure functional health literacy in the Philippines.
Social media use for patient care: an evaluation of health practitioners in Cross River state, Nigeria
Authors: Ikpi Ntongha Eni , Undelikwo Veronica Akwenabuaye , Ubi Lilian Otu
Published: October 2022

This study aimed to evaluate the extent to which health practitioners in Cross River state, Nigeria, use social media for patient care and to assess the barriers militating against its liberal use for patient care. The study adopted the cross-sectional survey design and used 550 respondents selected through the cluster, simple random and purposive sampling techniques, from selected secondary and tertiary health facilities. Furthermore, quantitative and qualitative methods involving the questionnaire and key informant interview respectively were used to elicit information from respondents. Quantitative data were analyzed using descriptive statistics while content analysis was used to handle qualitative data. The result of data analysis revealed that health practitioners in Cross River state, Nigeria do social media use for patient care very minimally and this is attributed to a wide range of factors, including the absence of a clear-cut regulatory framework governing social media use in health care delivery, and lack of institutionally provided resources for social media use. The study thus recommends that healthcare administrators must, as a matter of necessity, mainstream social media use into health care practice by flexible guidelines, regulations, and materials that would make social media use for patient care desirable by health practitioners in Nigeria.
Care and protection for healthcare workers during a COVID-19: a descriptive qualitative study in Indonesia
Authors: Helmi Mochamat , Sari Djayanti , Meliala Andreasta , Trisnantoro Laksono
Published: October 2022

This study aimed to explore the perspectives of care and protection of healthcare workers during the pandemic COVID-19 using a descriptive qualitative study in Indonesia. This study used a qualitative descriptive approach in COVID-19 National Referral Hospitals. Purposive sampling was used to collect the sample. There were 45 respondents, with 22 men and 23 women taking part in this study. The qualitative data were analyzed using the content analysis. Three themes that emerge from the data analysis: health protection, legal protection, and incentive schemes. Health protection including calculation of the medical team's workload and lack of a systematic procedure for medical team quarantine. There was a lack of legal basis for medical practice in long-term disaster services. Dimension of incentive scheme, including incentives shift from rewards to demands, changes in incentive regulations, and discrepancy in incentive calculation. By stressing protection and rewards for each level of the medical profession, it is hoped to boost motivation in actively participating and supporting the service of COVID-19 patients in critical conditions across Indonesia.
Food security and sociodemographic factors during COVID-19 pandemic in Indonesia
Authors: Ashari Chica Riska , Edwin Vebby Amellia , Suryani Dyah , Sunarti Sunarti , Buston Erni , Akbar Hairil , Suyitno Suyitno , Sera Agnesia Clarissa
Published: October 2022

The condition of the COVID-19 pandemic led to the government implementing the large-scale social restrictions regulation. It was implemented to overcome the spread of COVID-19 and also have an impact on community food security. This cross-sectional study aimed to examine socio-demographic factors and food security among communities during the COVID-19 pandemic in Indonesia. A total of 1,017 respondents involved in this rapid online survey. The result of this study found the strong factors related to food security were having stress or depression, poor dietary habits, and living alone. Furthermore, the low factors found such as being a female, unemployed, and living in Java Island. The government should give intervention for communities that got stressed, have poor dietary habits, and those who live alone without family during pandemic COVID-19.
Babies born to obese mothers: what are the characteristics and outcomes?
Authors: Yunanto Ari , Andayani Pudji , Halim Pricilia Gunawan , Kasab Julia
Published: October 2022

Obesity during pregnancy puts the mothers at risk of significant medical conditions and is also associated with some medical problems in neonates. This study aimed to analyze the characteristics and outcomes of babies born to obese mothers at a tertiary hospital in Banjarmasin, Ulin General Hospital. This study was observational using secondary data of neonates born at Ulin General Hospital, Banjarmasin, on January 2020-October 2021. The total number of subjects included in this study was 110, divided into two groups based on the obesity status of the mother (obese and non-obese). Common maternal characteristics of the obese mothers were having higher education (43.6%), being a housewife (67.3%), being diagnosed with severe preeclampsia (58.2%), and having infection risk (54.5%). Of the babies, 100% were delivered by C-section, 21.8% were premature, 12.7% had excessive birth weight, and 54.5% were requiring treatment before being discharged. For the outcomes, the average length of stay was 4.5±3.6 days (p<0.05) and the need for NICU admission was 20% (p>0.05). The most compelling characteristics and outcomes of babies born to obese mothers in this study were delivered by C-section, had excessive birth weight, unwell babies, and had a longer hospital stay.
Determinants of public compliance in face mask wearing to prevent COVID-19 transmission in Indonesia
Authors: Handayani Sri , Nuraini Syarifah , Pawitaningtyas Indah , Kurniawan Aan
Published: October 2022

To tackle the COVID-19 case, the COVID-19 task force in Indonesia urges the public to carry out COVID-19 prevention behaviors, including wearing masks. To find the determinants factors that affect public compliance with using masks, an online survey was conducted in Indonesia from June 27, to July 7, 2020. The analytical technique used in this study consisted of descriptive and inferential analysis. Of the 8,425 respondents, the majority (67.1%) had moderate mask compliance. Age, gender, education, income, and risk of infection have a significant relationship with mask compliance. Female respondents have higher compliance of wearing masks than men. Most respondents with high compliance in wearing masks are highly educated and have high incomes. The Boomer (elderly) group has the highest percentage who have low adherence to wearing masks. Respondents who stated they might be at risk of contracting COVID-19 had a high compliance score for wearing masks than respondents who stated they were unlikely to be infected. Socio-demographic factors significantly influence compliance with the use of masks during the COVID-19 pandemic in Indonesia. To improve health protocols compliance, the government needs to provide socialization, supervision, and evaluation of health protocols implementation in the community.
Interpersonal mattering and students’ friendship quality as predictors of subjective wellbeing
Authors: Yap Kylie Kai Ni , Prihadi Kususanto Ditto , Poay Susanna Lin Hong , Baharuddin Fahyuni
Published: October 2022

Subjective wellbeing (SWB) refers to one’s subjective assessment of happiness. Studies reported that happiness or SWB is predicted by friendship quality. However, others reported that SWB is strongly predicted by the sense that we matter to others (interpersonal mattering). This non-experimental correlational study aimed to test the hypothesis whether interpersonal mattering is a better predictor of SWB than friendship quality. One-hundred-and-nineteen emerging adults were recruited through convenience-purposive sampling with inclusion criteria includes Malaysian within 18 to 25 years of age. The sample size was gotten through G*Power calculator with .15 effect size, .95 Power, and .05 alpha level. The participants were asked to fill up the mcgill friendship questionnaire-friend’s functions (MFQFF), mattering to others questionnaire (MTOQ), and subjective happiness scale (SHS). We tested the hypotheses that while both friendship quality and interpersonal mattering predict SWB, the latter was the strongest predictor. Results of the multiple regression analyses showed that individuals who feels they matter to others might have higher SWB.
Psicopatologias retratadas em obras de arte: bases neurobiológicas, psicofarmacologia e abordagens não farmacológicas das principais psicopatologias
Authors:   Universidade de São Paulo. Faculdade de Filosofia, Ciências e Letras de Ribeirão Preto
Published: October 2022

Este material é um conjunto de estudos realizados na disciplina de Psicofarmacologia (5940934) por alunos do curso de Psicologia da FFCLRP-USP. O objetivo é apresentar conceitos básicos da área de psicofarmacologia, focalizando no conteúdo referente às bases neurobiológicas das principais psicopatologias citadas no Manual de Diagnóstico e Estatística de Transtornos Mentais (DSM-5). A proposta de investigar como essas psicopatologias são retratadas em obras artísticas visou tornar a elaboração de cada estudo mais didática e ilustrativa, além de permitir uma intersecção entre ciência e arte (mais especificamente, entre as áreas de Psicofarmacologia, Neurobiologia, Semiótica e Estética)
Emerging Evidence on Coronary Heart Disease Screening in Kidney and Liver Transplantation Candidates: A Scientific Statement From the American Heart Association
Authors: Cheng Xingxing S. , VanWagner Lisa B. , Costa Salvatore P. , Axelrod David A. , Bangalore Sripal , Norman Silas P. , Herzog Charles A. , Lentine Krista L. ,   on behalf of the American Heart Association Council on the Kidney in Cardiovascular Disease and Council on Cardiovascular Radiology and Intervention
Published: October 2022

Coronary heart disease is an important source of mortality and morbidity among kidney transplantation and liver transplantation candidates and recipients and is driven by traditional and nontraditional risk factors related to end-stage organ disease. In this scientific statement, we review evidence from the past decade related to coronary heart disease screening and management for kidney and liver transplantation candidates. Coronary heart disease screening in asymptomatic kidney and liver transplantation candidates has not been demonstrated to improve outcomes but is common in practice. Risk stratification algorithms based on the presence or absence of clinical risk factors and physical performance have been proposed, but a high proportion of candidates still meet criteria for screening tests. We suggest new approaches to pretransplantation evaluation grounded on the presence or absence of known coronary heart disease and cardiac symptoms and emphasize multidisciplinary engagement, including involvement of a dedicated cardiologist. Noninvasive functional screening methods such as stress echocardiography and myocardial perfusion scintigraphy have limited accuracy, and newer noninvasive modalities, especially cardiac computed tomography–based tests, are promising alternatives. Emerging evidence such as results of the 2020 International Study of Comparative Health Effectiveness With Medical and Invasive Approaches–Chronic Kidney Disease trial emphasizes the vital importance of guideline-directed medical therapy in managing diagnosed coronary heart disease and further questions the value of revascularization among asymptomatic kidney transplantation candidates. Optimizing strategies to disseminate and implement best practices for medical management in the broader end-stage organ disease population should be prioritized to improve cardiovascular outcomes in these populations.