bluuebunny/crossref_metadata_2025 huggingface dataset:
On upper bounds for asymptotic ideal-grade
Authors: Jahandoust Saeed
Published: April 2024

Let [Formula: see text] and [Formula: see text] be ideals in a Noetherian ring [Formula: see text] and let [Formula: see text] be nonunits in [Formula: see text]. Then [Formula: see text] is said to be an asymptotic sequence over [Formula: see text] if [Formula: see text] and if for all [Formula: see text], [Formula: see text] is not in any associated prime of the integral closure [Formula: see text] of [Formula: see text], where [Formula: see text] is very large. Let [Formula: see text] be the maximum number of elements in [Formula: see text] which form an asymptotic sequence over [Formula: see text]. It is characterized when [Formula: see text] is equal to: (i) [Formula: see text], the analytic spread of [Formula: see text], when [Formula: see text] is local; (ii) [Formula: see text], where [Formula: see text] is the maximum number of elements in [Formula: see text] which form an asymptotic sequence over [Formula: see text], and several consequences of these characterizations are given. Finally, if [Formula: see text] is local with maximal ideal [Formula: see text] then we reprove a known upper bound for [Formula: see text].
Real interpolation for variable martingale Hardy–Lorentz–Karamata spaces
Authors: Hao Zhiwei , Ding Xinru , Li Libo , Weisz Ferenc
Published: April 2024

In this paper, we study the real interpolation theory for variable Lorentz–Karamata spaces as well as for the corresponding martingale Hardy spaces. As a consequence, the generalization of Doob’s maximal inequality will be proved. Moreover, the atomic decompositions of the variable martingale Hardy–Lorentz–Karamata spaces are also presented. The results obtained here are new even for martingale Hardy–Lorentz–Karamata spaces.
A novel 5,10,15,20-tetrakis-(4-(triazol-1-yl)phenyl)porphyridine compound: Crystal structure, photophysical properties and TDDFT calculations
Authors: Liu Hao-Dong , Shao Xi-Yu , Zeng Long-Hua , Xu Yu-Yue , Liu Cheng , Dai Sheng-Ping , Pan Chang-Wang , Chen Wen-Tong
Published: April 2024

A novel 5,10,15,20-tetrakis-(4-(triazol-1-yl)phenyl)porphyridine compound, namely, Zn[5,10,15,20-tetrakis-(4-(triazol-1-yl)phenyl)porphyridine] (hereafter tagged as 1) was synthesized through a solvothermal reaction with mixed solvents at 413 K. The X-ray single-crystal structure of compound 1 is featured as a two-dimensional (2D) layer-like structure with the zinc ion located at the center of the 5,10,15,20-tetrakis-(4-(triazol-1-yl)phenyl)porphyridine. The macrocycle of the 5,10,15,20-tetrakis-(4-(triazol-1-yl)phenyl)porphyridine is coplanar. The zinc ion has six coordination and coordinates with three porphyridines. The photoluminescence spectra of compound 1 with DMF solution reveal that it shows upconversion red photoluminescence. The time-dependent density functional theory (TDDFT) calculation confirms that this upconversion red photoluminescence originated from the MLCT process (metal to ligand charge transfer). The CCT (Correlated Color Temperature) is 2200 K and the CIE (Commission Internationale de I’Éclairage) chromaticity coordinate is (0.6311, 0.3595) for compound 1. The UV-vis diffuse reflectance curve measured with a solid state sample reveals that compound 1 possesses a 2.75 eV band gap.
Anthraquinone fused sulfolenoporphyrins: Regulation of reactivity and property through annulations
Authors: Lin Qianghao , Ma Wenjing , Yu Yichen , Tang Yuqiu , Mo Wenyang , Li Chengjie , Li Qizhao , Li Yuxin , Liu Xiujun
Published: April 2024

The sulfolenoporphyrin-based Diels-Alder reaction is an efficient strategy in the construction of aromatic ring-fused porphyrins. However, the structure-reactivity relationship is still less explored. Here, we have synthesized the mono-, bis- and tri-anthraquinone fused sulfolenoporphyrins and explore the effect of anthraquinone fusion on their further Diels-Alder reactions. As a result, more anthraquinone fusions lead to higher reactivity but lower annulation yield. Theoretical calculation discloses that anthraquinone fusion has the HOMO of the dienes (i.e., the intermediates after extrusion of SO2 from sulfolenoporphyrins) raised owing to the [Formula: see text]-extension, affording high reactivity. However, as the number of ring fusions increases, the LUMO energy levels of dienes are reduced, which seems to benefit the side reaction (i.e., the dimer/oligomerization owing to the Diels-Alder reaction among porphyrin dienes), leading to the rapid consumption of dienes and low yields. Besides, the influence of the peripheral anthraquinone units on molecular stacking, absorption as well as aromaticity was investigated experimentally and computationally. In brief, this work has investigated the structure-reactivity relationship of sulfolenoporphyrins in the Dies-Alder reaction, which will help construct [Formula: see text]-extended porphyrin rationally.
Biomedical Applications of Cold Atmospheric Plasma: Cancer Therapy and Virus Inactivation
Authors: Thomas Som V. , Wang Yuxin , Shi Donglu
Published: April 2024

Cold atmospheric plasma (CAP), known for its ability to generate Reactive Oxygen Species (ROS) and Reactive Nitrogen Species (RNS), has emerged as a promising tool in many biomedical applications, including cancer therapeutics and virus inactivation. In cancer therapy, ROS and RNS induced by plasma have been shown to selectively target cancer cells, triggering apoptosis and inhibiting tumor growth while sparing healthy cells. This selective cytotoxicity makes plasma an attractive option for localized cancer treatment with minimal side effects. Additionally, the antimicrobial properties of ROS and RNS make plasma an effective agent for virus inactivation. By connecting the dots between cancer therapy and virus disinfection, this review paper sheds light on the potential of plasma-generated ROS and RNS as versatile tools in medical applications, offering a dual benefit of targeted cancer treatment and effective virus control. Specifically, this review explores the effects of CAP treatment on B16 melanoma cells, assessing changes in cell viability, proliferation, apoptosis and oxidative stress response. Dichloroacetate (DCA), a mitochondrial modulator, has shown promise in inducing apoptosis in melanoma cells. However, its clinical use is limited by side effects related to its neurotoxicity and suspected carcinogenicity. The potential of CAP in enhancing the therapeutic efficacy of DCA on B16-F10 melanoma apoptosis is also explored. CAP therapeutics for other types of cancers are also explored in this review. Alongside its implications in oncology, CAP has gathered substantial attention for its extraordinary potential in neutralizing viruses. CAP’s exceptional precision in targeting viral envelopes, genetic material and structural components disrupts their integrity and vital functions. This orchestrated mechanism offers a swift and efficacious route to render viruses inactive, encompassing both enveloped and nonenveloped viral types. In parallel pursuit, this review examines CAP-generated reactive species’ proficiency in deactivating SARS-CoV-2 across various surfaces. The inquiry entails subjecting surfaces to CAP treatment, succeeded by quantifying viral load and scrutinizing viral integrity. The outcomes gleaned from these investigations provide pivotal insights into CAP’s potential as a robust surface disinfection strategy, poised to combat the propagation of viral transmission.
Effect of tapered natural fiber on elastic properties of sisal fiber-reinforced composite: An experimental and micromechanics approach
Authors: Prasanthi P. Phani , Rao U. Koteswara , Madhav V. V. Venu , Kumar B. Kiran , Raghavender V. , Raj Vijilius Helena , Kumar Ashish , Ramu Gandikota , Abdullaev Shukhratovich
Published: April 2024

In the characterization of natural fiber-reinforced composites, it is crucial to consider the nonuniform cross-section of fibers extracted from plants or leaves, which results from the inherent variation in fiber diameter. This variation is a key aspect of the actual reinforcement behavior, and disregarding it by assuming a uniform cross-section can violate the physical understanding of the composite’s mechanics. This study focuses on characterizing the elastic properties of a natural tapered sisal fiber-reinforced epoxy composite, taking into account the variation in fiber diameter along its length. To achieve this, both experimental, analytical, and micromechanics methods are employed. The experimental approach involves conducting tests to measure the mechanical properties of the composite, while the micromechanics analysis provides a framework to understand the reinforcement behavior and predict the composite’s mechanical response. The study aims to identify and present various elastic properties of the composite, including the longitudinal modulus, transverse modulus, in-plane and out-of-plane shear modulus, and major and minor Poisson’s ratios. The fiber taper angle has a significant effect on longitudinal and transverse modulus and interfacial stresses. The longitudinal modulus experiences a reduction of 25.9% when increasing the taper angle from [Formula: see text] to [Formula: see text] at a higher fiber volume fraction (40%). However, at a lower volume fraction of the same fiber (10%), the reduction in modulus is limited to 5.74%. Similarly, the transverse modulus is also affected by the taper angle. At the higher fiber volume fraction, there is a decrease of 24.52%, whereas at the lower volume fraction and higher taper angle of the fiber, the decrement is 4.94%.
Evaluation method for the intactness of tunnel face surrounding rock based on tunnel face images
Authors: Yang Gang , Li Tianbin , Tang Hao , Xing Dongwei , Hu Yao , Li Shisen
Published: April 2024

The intactness of rock masses is a fundamental parameter in classifying surrounding rocks. Due to limitations imposed by the extent of tunnel face outcrops, the assessment of rock mass intactness necessitates the manual extraction of the positions, orientations and spacing of joints/fissures. To mitigate the labour-intensive nature of this process, in this paper deep learning is employed to develop an integrated method for the automated extraction of joints/fissures and the quantitative analysis of rock mass intactness. We introduce an image preprocessing method based on multiscale histogram equalization to obtain high-contrast, low-noise images. The DeepIntactness model, which incorporates the strategy of curriculum learning to utilize a large number of unlabelled tunnel rock images for model training, is introduced for the extraction of joints/fissures. Following the extraction of joints/fissures, a multiline centre statistic method based on the rock mass block index method is employed to evaluate the intactness of the most vulnerable part of the tunnel face. By applying this approach to an engineering structure, its capacity to automatically extract and quantitatively evaluate the engineering properties of the surrounding rock mass intactness is demonstrated. Hence, this method provides a novel approach to evaluating the tunnel surrounding rock intactness using two-dimensional images.

Supplementary material:
The I-RBI calculation process of the cases in this paper is available at
https://doi.org/10.6084/m9.figshare.c.7154677
Creating Apps for Community and Social Good: Preliminary Learning Outcomes from a Middle School Computer Science Curriculum
Authors: Ni Lijun , Bausch Gillian , Thomas-Cappello Elizabeth , Martin Fred , Feliciano Bernardo
Published: April 2024

This study examined student learning outcomes from a middle school computer science (CS) curriculum developed through a researcher and practitioner partnership (RPP) project. The curriculum is based on students creating mobile apps that serve community and social good. We collected two sets of data from 294 students in three urban districts: (1) pre- and post-survey responses on their learning experiences and attitudes toward learning CS and creating community-serving apps; (2) the apps created by those students. The analysis of student apps indicated that students were able to create basic apps that connected with their personal interests, life experiences, school community, and the larger society. Students were significantly more confident in coding and creating community-focused apps after completing the course, regardless of gender, race/ethnicity, and grade. However, their interest in solving coding problems and continuing to learn CS decreased afterward. Analyses of students’ attitudes by gender, grade, and race/ethnicity showed significant differences among students in some groups. Seventh-grade students rated more positive on their attitudes than eighth graders. Students identifying with different race/ethnicity groups indicated significantly different attitudes, especially students identifying as Southeast Asian, Black/African American, and Hispanic/Latino. Self-identified male students also reported stronger interest and more positive attitudes overall than self-identified female students. Students also reported positive experiences in learning how to create real apps serving their community, while there were disparities in their experiences with coding in general and some of the instructional tools used in the class.
Terra Incognita: The Governance of Artificial Intelligence in Global Perspective
Authors: Stanger Allison , Kraus Jakub , Lim Woojin , Millman-Perlah Georgia , Schroeder Mitchell
Published: April 2024

While generative AI shares some similarities with previous technological breakthroughs, it also raises unique challenges for containing social and economic harms. State approaches to AI governance vary; some lay a foundation for transnational governance whereas others do not. We consider some technical dimensions of AI safety in both open and closed systems, as well as the ideas that are presently percolating to safeguard their future development. Examining initiatives for the global community and for the coalition of open societies, we argue for building a dual-track interactive strategy for containing AI's potentially nightmarish unintended consequences. We conclude that AI safety is AI governance, which means that pluralist efforts to bridge gaps between theory and practice and the STEM–humanities divide are critical for democratic sustainability.
The Politics of Contagion: States, Societies, and the Control and Consequences of Infectious Diseases
Authors: Singh Prerna
Published: April 2024

The study of contagion offers important but underexplored opportunities to rethink and advance our understanding of key concepts in political science. These include notably state capacity; social policy; state–society relations, especially the role of trust; nationalism and social solidarity; exclusionary dynamics, such as xenophobia, prejudice, and discrimination; and within political psychology, the role of emotions, including disgust. This article reviews studies on contagion and health within and adjacent to political science. While taking note of the surge of studies around COVID-19, this article focuses on work on infectious disease before and beyond the pandemic. It analyzes the scholarship as it sheds light on the control of infectious diseases, on the one hand, and on the consequences of that control, on the other, while also pointing to connections and feedback loops, especially as they open avenues for future research.
Thermal Annealing Effect on Hydrothermal Synthesized Li4Ti5O12/TiO2 as Anode Material for Lithium-Ion Batteries
Authors: Merazga Saloua , Boudeffar Fatima , Rahal Badis , Berouaken Malika , Mebarki Mourad , Ayouz Katia , Ayat Maha , Gabouze Nouredine
Published: April 2024

The thermal annealing effect on the morphological, structural and electrochemical properties of hydrothermal synthesized Li4Ti5O12 / TiO2 has been studied. Lithium titanate (Li4Ti5O12) nanopowders are successfully synthesized by hydrothermal method using titanuim tetrabutyl and lithium hydroxide followed by thermal annealing process at different temperatures: 500 °C, 800 °C and 900 °C. The X-ray diffraction (XRD) patterns indicates the appearance of the Li4Ti5O12 phase at a temperature above 800 °C formed after the reaction of the two phases: TiO2 and Li2TiO3 which appear at 500 °C. Though, the prepared electrode by the powder annealed at 800 °C shows an initial capacity of about 173.1 mAh g−1 (0.1 C), which retained at 75.6 mAh g−1 after 100 cycles.
Experimental Study on Mechanical Properties of CFRP‐Confined Concrete Columns under Continuous Semi‐Submergence of Sulfate
Authors: Cai Mingxi , Shao Lijun , Zhang Jiawei , Xu Kaijin , Zhang Jie , Li Penggang
Published: April 2024

To investigate the mechanical properties of carbon‐fiber‐reinforced‐polymer (CFRP)‐restrained concrete in a saline soil environment, the degradation of the mechanical properties of CFRP‐restrained concrete columns under the effect of continuous sulfate semisoak erosion is investigated based on sulfate continuous semisoak erosion, and unrestrained concrete columns with the same specifications are used in comparison tests. The results show that the strength, stiffness, and ductility of both plain concrete columns and CFRP‐confined concrete columns first increase and then decrease after the continuous semi‐submersion erosion by sulfate; compared with plain concrete columns, the decline rates of strength and stiffness of CFRP‐confined concrete columns are significantly lower, and the CFRP demonstrates a certain protective effect on the core concrete. Through a regression analysis of experimental data, strength and ultimate strain models of CFRP‐confined concrete columns under the continuous semi‐submergence of sulfate are proposed based on the existing ultimate strength and ultimate strain models of CFRP‐confined ordinary concrete columns, and a stress–strain model of CFRP‐confined concrete columns under the continuous semi‐submergence of sulfate is established. Based on a comparison with experimental data, the model prediction curves indicate good agreement with the experimental curves and can therefore provide a theoretical basis and practical reference for CFRP‐reinforced semi‐submerged concrete in saline soil areas.
The Prevalence of Depression and Anxiety and Its Association with Sleep Quality in the First-Year Medical Science Students
Authors: Garmabi Maryam , Andishmand Zahra , Naderi Fatemeh , Sharifnezhad Ahmad , Darrudi Fatemeh , Malekzadeh Roghayeh , Amini Asieh , Gholami Ali
Published: April 2024

Background and Aim. As an integral matter at the global level, sleep quality can be pertinent to some factors, namely, depression and anxiety. Considering this critical issue and its effects and consequences, the current cross-sectional study has centralized its aim on assessing the association between depression and anxiety with sleep quality in freshmen students in the context of Neyshabur University of Medical Sciences (NUMS). Methods. A total number of 471 freshmen students (NUMS) participated in the study, pinpointing that the data are collected in 2019 and 2020. In line with measuring depression, anxiety, and sleep quality, the Persian Beck Depression Inventory-II, Beck Anxiety Inventory, and Pittsburgh Sleep Quality Index were employed. The associations between depression and anxiety with sleep quality were assessed by using the multiple logistic regression model. All statistical analyses were conducted in STATA14, and the significant level was set at P<0.05. Results. The prevalence of depression, anxiety, and poor sleep quality in the study population was 21.4%, 31.9%, and 28%, respectively. Analytical analyses indicated that after adjusting for studied covariates, the odds of poor sleep quality in individuals with depression were 3.5 times higher compared to the counter group (P<0.001). Moreover, the odds of poor sleep quality in individuals with anxiety were 2.1 times higher compared to the counter group (P<0.001). Conclusion. Noticeable proportion of freshmen students suffer from depression and anxiety; in line with such a critical issue, our study found that depression and anxiety had a statistical association with sleep quality in study population. From this respect, it seems that providing essential interventions and psychological counseling services could be constructive for the freshmen medical students.
Some New Identities Related to Dedekind Sums Modulo a Prime
Authors: Hu Jiayuan
Published: April 2024

The main purpose of this article is to use some identities of the classical Gauss sums, the properties of character sums, and Dedekind sums (modulo an odd prime) to study the computational problem of one-kind mean values related to Dedekind sums and give some interesting identities for them.
Supplementary Figure S1 from Discovery of a Novel Potent EGFR Inhibitor Against EGFR Activating Mutations and On-Target Resistance in NSCLC
Authors: Lee Eun Ji , Oh Seung Yeon , Lee You Won , Kim Ju Young , Kim Min-Je , Kim Tae Ho , Lee Jii Bum , Hong Min Hee , Lim Sun Min , Baum Anke , Woelflingseder Lydia , Engelhardt Harald , Petronczki Mark , Solca Flavio , Yun Mi Ran , Cho Byoung Chul
Published: April 2024

Tumor growth curve and body weight for each individual mouse in YU-1097 xenograft model
Supplementary Figure S8 from Development of Chromosome 1q+ Specific Treatment for Highest Risk Pediatric Posterior Fossa Ependymoma
Authors: Griesinger Andrea M. , Calzadilla Annaliese J. , Grimaldo Enrique , Donson Andrew M. , Amani Vladimir , Pierce Angela M. , Steiner Jenna , Kargar Soudabeh , Serkova Natalie J. , Bertrand Kelsey C. , Wright Karen D. , Vibhakar Rajeev , Hankinson Todd , Handler Michael , Lindsay Holly B. , Foreman Nicholas K. , Dorris Kathleen
Published: April 2024

MAF-811_XC in vivo survival with radiation and chemotherapy.
Supplementary Methods S1 from Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma
Authors: Habashy Karl J. , Dmello Crismita , Chen Li , Arrieta Victor A. , Kim Kwang-Soo , Gould Andrew , Youngblood Mark W. , Bouchoux Guillaume , Burdett Kirsten B. , Zhang Hui , Canney Michael , Stupp Roger , Sonabend Adam M.
Published: April 2024

Supplementary Material and Methods
Supplementary Figure S3 from A Phase I Study of Acapatamab, a Half-life Extended, PSMA-Targeting Bispecific T-cell Engager for Metastatic Castration-Resistant Prostate Cancer
Authors: Dorff Tanya , Horvath Lisa G. , Autio Karen , Bernard-Tessier Alice , Rettig Matthew B. , Machiels Jean-Pascal , Bilen Mehmet A. , Lolkema Martijn P. , Adra Nabil , Rottey Sylvie , Greil Richard , Matsubara Nobuaki , Tan Daniel S.W. , Wong Alvin , Uemura Hiroji , Lemech Charlotte , Meran Johannes , Yu Youfei , Minocha Mukul , McComb Mason , Penny Hweixian Leong , Gupta Vinita , Hu Xuguang , Jurida Gabor , Kouros-Mehr Hosein , Janát-Amsbury Margit M. , Eggert Tobias , Tran Ben
Published: April 2024

Duration of PSA response in dose expansion
Supplementary Fig. S7 from Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy
Authors: Nguyen Rosa , Doubrovina Ekaterina , Mousset Charlotte M. , Jin Benjamin Y. , Okada Reona , Zhang Xiyuan , Clavel Arina , Reyes-Gonzalez Jeyshka M. , Dyomin Vadim , Diaz Louis , Zhang Ling , Abbas Shahroze , Sun Ming , Hsieh Chao-Ming , Ho Mitchell , Shern Jack F. , Gulley James L. , Hinrichs Christian S.
Published: April 2024

Replicate rechallenge experiment in vitro.
Supplementary Figure 4 from CB307: A Dual Targeting Costimulatory Humabody VH Therapeutic for Treating PSMA-Positive Tumors
Authors: Archer Sophie , Brailey Phillip M. , Song Minjung , Bartlett Phillip D. , Figueiredo Ines , Gurel Bora , Guo Christina , Brucklacher-Waldert Verena , Thompson H. Lorraine , Akinwale Jude , Boyle Samantha E. , Rossant Christine , Birkett Neil R. , Pizzey Julia , Maginn Mark , Legg James , Williams Richard , Johnston Colette M. , Bland-Ward Philip , de Bono Johann S. , Pierce Andrew J.
Published: April 2024

Supplementary Figure 4: Binding kinetics of CB307 to human PSMA, CD137 and serum albumin (HSA)
Supplementary Figure S5 from Germline Mutations of Holliday Junction Resolvase Genes in Multiple Primary Malignancies Involving Lung Cancer Lead to PARP Inhibitor Sensitization
Authors: Wang Haoran , Chen Yuping , Wang Xinshu , Huang Binhao , Xie Juntao , Yin Hui , Yang Jie , Wu Jinhuan , Yuan Jian , Zhang Jie
Published: April 2024

Supplementary Figure S5: Effects of HJR-VUS on RAD51 binding.
Supplementary Figure S3 from Germline Mutations of Holliday Junction Resolvase Genes in Multiple Primary Malignancies Involving Lung Cancer Lead to PARP Inhibitor Sensitization
Authors: Wang Haoran , Chen Yuping , Wang Xinshu , Huang Binhao , Xie Juntao , Yin Hui , Yang Jie , Wu Jinhuan , Yuan Jian , Zhang Jie
Published: April 2024

Supplementary Figure S3: Effects of HJR-VUS on chromosome damage in H1975 cells.
Supplementary Table S4 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression
Authors: Gitto Sarah B. , Whicker Margaret , Davies Gareth , Kumar Sushil , Kinneer Krista , Xu Haineng , Lewis Arthur , Mamidi Srinivas , Medvedev Sergey , Kim Hyoung , Anderton Judith , Tang E. Jessica , Ferman Benjamin , Coats Steven , Wilkinson Robert W. , Brown Eric , Powell Daniel J. , Simpkins Fiona
Published: April 2024

IHC analysis of human ovarian cancer tumors and subject information.
Supplementary Table S2 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression
Authors: Gitto Sarah B. , Whicker Margaret , Davies Gareth , Kumar Sushil , Kinneer Krista , Xu Haineng , Lewis Arthur , Mamidi Srinivas , Medvedev Sergey , Kim Hyoung , Anderton Judith , Tang E. Jessica , Ferman Benjamin , Coats Steven , Wilkinson Robert W. , Brown Eric , Powell Daniel J. , Simpkins Fiona
Published: April 2024

Summary of cell lines growth conditions.
Supplementary Methods S1 from A B7-H4–Targeting Antibody–Drug Conjugate Shows Antitumor Activity in PARPi and Platinum-Resistant Cancers with B7-H4 Expression
Authors: Gitto Sarah B. , Whicker Margaret , Davies Gareth , Kumar Sushil , Kinneer Krista , Xu Haineng , Lewis Arthur , Mamidi Srinivas , Medvedev Sergey , Kim Hyoung , Anderton Judith , Tang E. Jessica , Ferman Benjamin , Coats Steven , Wilkinson Robert W. , Brown Eric , Powell Daniel J. , Simpkins Fiona
Published: April 2024

Supplemental Methods
Supplementary Table 7 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Authors: Singh Harshabad , Sahgal Pranshu , Kapner Kevin , Corsello Steven M. , Gupta Hersh , Gujrathi Rahul , Li Yvonne Y. , Cherniack Andrew D. , El Alam Raquelle , Kerfoot Joseph , Andrews Elizabeth , Lee Annette , Nambiar Chetan , Hannigan Alison M. , Remland Joshua , Brais Lauren , Leahy Meghan E. , Rubinson Douglas A. , Schlechter Benjamin L. , Meyerson Matthew , Kuang Yanan , Paweletz Cloud P. , Lee Jessica K. , Quintanilha Julia C.F. , Aguirre Andrew J. , Perez Kimberly J. , Huffman Brandon M. , Rossi Humberto , Abrams Thomas A. , Kabraji Sheheryar , Trusolino Livio , Bertotti Andrea , Sicinska Ewa T. , Parikh Aparna R. , Wolpin Brian M. , Schrock Alexa B. , Giannakis Marios , Ng Kimmie , Meyerhardt Jeffrey A. , Hornick Jason L. , Sethi Nilay S. , Cleary James M.
Published: April 2024

Supplementary Table 7. MAPK alterations are present in 20% of HER2+ CRC in the FMI genomic cohort.
Supplementary Methods 1 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Authors: Singh Harshabad , Sahgal Pranshu , Kapner Kevin , Corsello Steven M. , Gupta Hersh , Gujrathi Rahul , Li Yvonne Y. , Cherniack Andrew D. , El Alam Raquelle , Kerfoot Joseph , Andrews Elizabeth , Lee Annette , Nambiar Chetan , Hannigan Alison M. , Remland Joshua , Brais Lauren , Leahy Meghan E. , Rubinson Douglas A. , Schlechter Benjamin L. , Meyerson Matthew , Kuang Yanan , Paweletz Cloud P. , Lee Jessica K. , Quintanilha Julia C.F. , Aguirre Andrew J. , Perez Kimberly J. , Huffman Brandon M. , Rossi Humberto , Abrams Thomas A. , Kabraji Sheheryar , Trusolino Livio , Bertotti Andrea , Sicinska Ewa T. , Parikh Aparna R. , Wolpin Brian M. , Schrock Alexa B. , Giannakis Marios , Ng Kimmie , Meyerhardt Jeffrey A. , Hornick Jason L. , Sethi Nilay S. , Cleary James M.
Published: April 2024

Supplementary Methods
Supplementary Figure 5 from RAS/RAF Comutation and ERBB2 Copy Number Modulates HER2 Heterogeneity and Responsiveness to HER2-directed Therapy in Colorectal Cancer
Authors: Singh Harshabad , Sahgal Pranshu , Kapner Kevin , Corsello Steven M. , Gupta Hersh , Gujrathi Rahul , Li Yvonne Y. , Cherniack Andrew D. , El Alam Raquelle , Kerfoot Joseph , Andrews Elizabeth , Lee Annette , Nambiar Chetan , Hannigan Alison M. , Remland Joshua , Brais Lauren , Leahy Meghan E. , Rubinson Douglas A. , Schlechter Benjamin L. , Meyerson Matthew , Kuang Yanan , Paweletz Cloud P. , Lee Jessica K. , Quintanilha Julia C.F. , Aguirre Andrew J. , Perez Kimberly J. , Huffman Brandon M. , Rossi Humberto , Abrams Thomas A. , Kabraji Sheheryar , Trusolino Livio , Bertotti Andrea , Sicinska Ewa T. , Parikh Aparna R. , Wolpin Brian M. , Schrock Alexa B. , Giannakis Marios , Ng Kimmie , Meyerhardt Jeffrey A. , Hornick Jason L. , Sethi Nilay S. , Cleary James M.
Published: April 2024

Supplementary Figure 5. LS180 and SW480 harbor endogenous hotspot mutations in KRAS.
Figure 4 from Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging
Authors: Malviya Gaurav , Lannagan Tamsin R.M. , Johnson Emma , Mackintosh Agata , Bielik Robert , Peters Adam , Soloviev Dmitry , Brown Gavin , Jackstadt Rene , Nixon Colin , Gilroy Kathryn , Campbell Andrew , Sansom Owen J. , Lewis David Y.
Published: April 2024

Imaging signatures depend on tumor context. A, The generation of mouse models. B, Transverse and coronal PET/MRI slices images showing [18F]FDG uptake in subcutaneous and orthotopic organoid models and GEMM of KrasG12D/+ Trp53fl/fl Rosa26N1icd/+ (KPN) colon cancer. KPN subcutaneous images reproduced here from Fig. 2B for comparison with KPN orthograft and GEMM. Tumors are outlined with a white dotted line. C, Standard uptake peak values (SUVpeak) PET quantification from images in B (n = 4 mice/model). Data compared using ANOVA followed by Fisher least significant difference test. D, Transverse and coronal PET/MRI slices images showing [18F]FDG uptake in subcutaneous and orthotopic KPN and Apcfl/+ KrasG12D/+ Trp53fl/fl Tgfbr1 fl/fl (AKPT) organoid models of colon cancer. Tumors are outlined with a white dotted line. KPN images reproduced here from Figs. 2B and 4B and for comparison to AKPT. E, SUVpeak quantification from images in panel D (Numbers inside bars show sample size, n). Data compared using two-way ANOVA, with the results of injection site shown. Details of all mice used in these studies are presented in Supplementary Table S1. F, Representative GLUT-1 immunohistochemistry of tumors from mice shown in panel E. Black scale bars represents 100 μm. G, H-score of GLUT-1 immunohistochemistry from mice shown in panel E. Box and whisker plots show range, median and interquartile range. Error bars in panel C and E represent standard deviation. Data compared using two-way ANOVA, with the results of injection site shown, * P < 0.05, ** P < 0.01, *** P < 0.001. (A, Created with BioRender.com.)
Figure 3 from Noninvasive Stratification of Colon Cancer by Multiplex PET Imaging
Authors: Malviya Gaurav , Lannagan Tamsin R.M. , Johnson Emma , Mackintosh Agata , Bielik Robert , Peters Adam , Soloviev Dmitry , Brown Gavin , Jackstadt Rene , Nixon Colin , Gilroy Kathryn , Campbell Andrew , Sansom Owen J. , Lewis David Y.
Published: April 2024

PET imaging can distinguish different colon subcutaneous organoid cancer models and individual driver genes. A, The data processing workflow for comparing PET radiotracer discriminatory power and the model/gene uniqueness. B, Separation matrix and statistics of the area under the ROC curves for each tracer and model. C, Red highlighted box showing boxplot and ROC curves for [18F]FDG in the BMT (n = 6 subcutaneous organoid allografts) compared with other models (n = 19), each point represents a mouse. Numbers inside bars show sample size, n. Data compared using unpaired t test. D, Separation matrix and statistics of the area under the ROC curves for each tracer and gene. Tgfbr1/Alk5 fl/fl and Tgfbr2 fl/fl are combined as TGFb for this analysis. E, Red highlighted box showing boxplot and ROC curves for [18F]FLT in the Kras (n = 18) compared to other subcutaneous models (n = 6), each point represents a mouse. Numbers inside bars show n. Data compared using unpaired t test. Error bars in C and D represent SD. *, P < 0.05; **, P < 0.01; ***, P < 0.001 for unpaired t tests and AUC ROC. Each analysis stands on its own; no multiple comparison testing was used. See extended datasets in Supplementary Fig. S4. (A, Created with BioRender.com.)
Supplementary Figure S2 from Cadonilimab Combined with Chemotherapy with or without Bevacizumab as First-Line Treatment in Recurrent or Metastatic Cervical Cancer (COMPASSION-13): A Phase 2 Study
Authors: Lou Hanmei , Cai Hongbing , Huang Xin , Li Guiling , Wang Li , Liu Fei , Qin Wenjing , Liu Ting , Liu Wei , Wang Zhongmin Maxwell , Li Baiyong , Xia Yu , Wang Jing
Published: April 2024

Supplementary Figure S2. Kaplan-Meier Curve of Progression Free Survival (PFS).
Supplementary Figure S4 from Obinutuzumab Pretreatment as a Novel Approach to Mitigate Formation of Anti-Drug Antibodies Against Cergutuzumab Amunaleukin in Patients with Solid Tumors
Authors: Peters Solange , Angevin Eric , Alonso-Gordoa Teresa , Rohrberg Kristoffer , Melero Ignacio , Mellado Begoña , Perez-Gracia Jose-Luis , Tabernero Josep , Adessi Celine , Boetsch Christophe , Watson Carl , Dal Porto Joseph , Dejardin David , Del Nagro Christopher , Nicolini Valeria , Evers Stefan , Klein Christian , Leutgeb Barbara , Pisa Pavel , Rossmann Eva , Saro José , Umana Pablo , Charo Jehad , Teichgräber Volker , Steeghs Neeltje
Published: April 2024

Supplementary Figure S4. Full patient disposition for the Phase I/Ib substudies. A, CEA-IL2v monotherapy with or without obinutuzumab pretreatment.
The red boxes indicate the data used to support the information included within the manuscript. B, CEA-IL2v in combination with atezolizumab with or without obinutuzumab pretreatment. The red boxes indicate the data used to support the information included within the manuscript.
Supplementary Figure 8 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial
Authors: Parra Edwin Roger , Zhang Jiexin , Duose Dzifa Yawa , Gonzalez-Kozlova Edgar , Redman Mary W. , Chen Hong , Manyam Ganiraju C. , Kumar Gayatri , Zhang Jianhua , Song Xingzhi , Lazcano Rossana , Marques-Piubelli Mario L. , Laberiano-Fernandez Caddie , Rojas Frank , Zhang Baili , Taing Len , Jhaveri Aashna , Geisberg Jacob , Altreuter Jennifer , Michor Franziska , Provencher James , Yu Joyce , Cerami Ethan , Moravec Radim , Kannan Kasthuri , Luthra Rajyalakshmi , Alatrash Gheath , Huang Hsin-Hui , Xie Hui , Patel Manishkumar , Nie Kai , Harris Jocelyn , Argueta Kimberly , Lindsay James , Biswas Roshni , Van Nostrand Stephen , Kim-Schulze Seunghee , Gray Jhanelle E. , Herbst Roy S. , Wistuba Ignacio I. , Gettinger Scott , Kelly Karen , Bazhenova Lyudmila , Gnjatic Sacha , Lee J. Jack , Zhang Jianjun , Haymaker Cara
Published: April 2024

Supplementary Figure 8. Integration analysis identifies immune features associated with progression free survivial.
Supplementary Data1 from One CD4+TCR and One CD8+TCR Targeting Autochthonous Neoantigens Are Essential and Sufficient for Tumor Eradication
Authors: Wolf Steven P. , Anastasopoulou Vasiliki , Drousch Kimberley , Diehl Markus I. , Engels Boris , Yew Poh Yin , Kiyotani Kazuma , Nakamura Yusuke , Schreiber Karin , Schreiber Hans , Leisegang Matthias
Published: April 2024

Includes Supplementary Figures 1, 2, 3, 4, 5, 6, 7, 8 and 9. Description of Supplementary Videos S1 and S2. Detailed Supplementary Tables S1, S2 and S3.
Supplementary Figure 3 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial
Authors: Parra Edwin Roger , Zhang Jiexin , Duose Dzifa Yawa , Gonzalez-Kozlova Edgar , Redman Mary W. , Chen Hong , Manyam Ganiraju C. , Kumar Gayatri , Zhang Jianhua , Song Xingzhi , Lazcano Rossana , Marques-Piubelli Mario L. , Laberiano-Fernandez Caddie , Rojas Frank , Zhang Baili , Taing Len , Jhaveri Aashna , Geisberg Jacob , Altreuter Jennifer , Michor Franziska , Provencher James , Yu Joyce , Cerami Ethan , Moravec Radim , Kannan Kasthuri , Luthra Rajyalakshmi , Alatrash Gheath , Huang Hsin-Hui , Xie Hui , Patel Manishkumar , Nie Kai , Harris Jocelyn , Argueta Kimberly , Lindsay James , Biswas Roshni , Van Nostrand Stephen , Kim-Schulze Seunghee , Gray Jhanelle E. , Herbst Roy S. , Wistuba Ignacio I. , Gettinger Scott , Kelly Karen , Bazhenova Lyudmila , Gnjatic Sacha , Lee J. Jack , Zhang Jianjun , Haymaker Cara
Published: April 2024

Supplementary Figure 3. Spatial organization and clustering in early progressors.
Supplementary Figure 2 from Multi-omics Analysis Reveals Immune Features Associated with Immunotherapy Benefit in Patients with Squamous Cell Lung Cancer from Phase III Lung-MAP S1400I Trial
Authors: Parra Edwin Roger , Zhang Jiexin , Duose Dzifa Yawa , Gonzalez-Kozlova Edgar , Redman Mary W. , Chen Hong , Manyam Ganiraju C. , Kumar Gayatri , Zhang Jianhua , Song Xingzhi , Lazcano Rossana , Marques-Piubelli Mario L. , Laberiano-Fernandez Caddie , Rojas Frank , Zhang Baili , Taing Len , Jhaveri Aashna , Geisberg Jacob , Altreuter Jennifer , Michor Franziska , Provencher James , Yu Joyce , Cerami Ethan , Moravec Radim , Kannan Kasthuri , Luthra Rajyalakshmi , Alatrash Gheath , Huang Hsin-Hui , Xie Hui , Patel Manishkumar , Nie Kai , Harris Jocelyn , Argueta Kimberly , Lindsay James , Biswas Roshni , Van Nostrand Stephen , Kim-Schulze Seunghee , Gray Jhanelle E. , Herbst Roy S. , Wistuba Ignacio I. , Gettinger Scott , Kelly Karen , Bazhenova Lyudmila , Gnjatic Sacha , Lee J. Jack , Zhang Jianjun , Haymaker Cara
Published: April 2024

Supplementary Figure 2. Spatial organization and cell clustering in exceptional responders.
Supplementary Table S8 from Safety Profile and Adverse Event Management for Futibatinib, An Irreversible FGFR1–4 Inhibitor: Pooled Safety Analysis of 469 Patients
Authors: Meric-Bernstam Funda , Hollebecque Antoine , Furuse Junji , Oh Do-Youn , Bridgewater John A. , Shimura Masashi , Anderson Bailey , Hangai Nanae , Wacheck Volker , Goyal Lipika
Published: April 2024

Treatment-related SAEs
Data from Paclitaxel and Carboplatin in Combination with Low-intensity Pulsed Ultrasound for Glioblastoma
Authors: Habashy Karl J. , Dmello Crismita , Chen Li , Arrieta Victor A. , Kim Kwang-Soo , Gould Andrew , Youngblood Mark W. , Bouchoux Guillaume , Burdett Kirsten B. , Zhang Hui , Canney Michael , Stupp Roger , Sonabend Adam M.
Published: April 2024

AbstractPurpose:
We recently reported on clinical trials for patients with recurrent glioblastoma where low-intensity pulsed ultrasound and microbubbles (LIPU/MB) improved paclitaxel or carboplatin delivery into the brain. Here, we report variable local tumor control with paclitaxel at the maximal/target dose in our phase I trial (NCT04528680). To address this, we investigated the combination of paclitaxel with carboplatin in preclinical glioma models.
Experimental Design:
We performed MRI-based analysis to evaluate disease control in patients from our trial. We studied the cytotoxicity of paclitaxel and carboplatin against 11 human glioma lines as monotherapy and in combination at concentrations derived from human intraoperative studies. Synergy was assessed with the Loewe model and the survival benefit evaluated in two xenografts. We examined the effects on cell cycle progression, DNA damage, and apoptosis.
Results:
Patients treated with paclitaxel and LIPU/MB exhibited variable local tumor control, which correlated with overall survival. We observed limited cross-resistance to paclitaxel and carboplatin in glioma lines, with almost a third of them being exclusively susceptible to one drug. This combination led to susceptibility of 81% of lines and synergy in 55% of them. The combination proved more efficacious in two intracranial xenografts when administered with LIPU/MB, leading to complementary effects on cell cycle arrest.
Conclusions:
Combining paclitaxel and carboplatin in gliomas may be more efficacious than monotherapy, as in other cancers, due to synergy and independent susceptibility to each drug. These results form the basis for an ongoing phase II trial (NCT04528680) where we investigate this combination with LIPU/MB.
Data from Cooperative Armoring of CAR and TCR T Cells by T Cell–Restricted IL15 and IL21 Universally Enhances Solid Tumor Efficacy
Authors: Nguyen Rosa , Doubrovina Ekaterina , Mousset Charlotte M. , Jin Benjamin Y. , Okada Reona , Zhang Xiyuan , Clavel Arina , Reyes-Gonzalez Jeyshka M. , Dyomin Vadim , Diaz Louis , Zhang Ling , Abbas Shahroze , Sun Ming , Hsieh Chao-Ming , Ho Mitchell , Shern Jack F. , Gulley James L. , Hinrichs Christian S.
Published: April 2024

AbstractPurpose:
Chimeric antigen receptor (CAR) and T-cell receptor (TCR) T-cell therapies are effective in a subset of patients with solid tumors, but new approaches are needed to universally improve patient outcomes. Here, we developed a technology to leverage the cooperative effects of IL15 and IL21, two common cytokine-receptor gamma chain family members with distinct, pleiotropic effects on T cells and other lymphocytes, to enhance the efficacy of adoptive T cells.
Experimental Design:
We designed vectors that induce the constitutive expression of either membrane-tethered IL15, IL21, or IL15/IL21. We used clinically relevant preclinical models of transgenic CARs and TCRs against pediatric and adult solid tumors to determine the effect of the membrane-tethered cytokines on engineered T cells for human administration.
Results:
We found that self-delivery of these cytokines by CAR or TCR T cells prevents functional exhaustion by repeated stimulation and limits the emergence of dysfunctional natural killer (NK)-like T cells. Across different preclinical murine solid tumor models, we observed enhanced regression with each individual cytokine but the greatest antitumor efficacy when T cells were armored with both.
Conclusions:
The coexpression of membrane-tethered IL15 and IL21 represents a technology to enhance the resilience and function of engineered T cells against solid tumors and could be applicable to multiple therapy platforms and diseases.

See related commentary by Ruffin et al., p. 1431
Abstract LT10: Recurrent FBXW7 Mutations Bypass Wnt/β-catenin Addiction in Cancer
Authors: Zhong Zheng , Virshup David
Published: April 2024

Inactivating mutations in RNF43 or gene fusions involving RSPO2/3 are potent activators of ligand-dependent Wnt signaling and drive multiple human cancers. Pharmacologically targeting the biogenesis of Wnt ligands, e.g., with PORCN inhibitors, is being investigated in clinical trials for treating RNF43-mutant/RSPO-fusion cancers. But, the therapeutic response is heterogeneous. Here we show that the tumor suppressor FBXW7 is frequently mutated in RNF43-mutant/RSPO-fusion tumors. Multiple RNF43-mutant/RSPO-fusion cancers harboring FBXW7 mutations show resistance to Wnt pathway blockade, while silencing FBXW7 by truncation or expressing a hotspot mutant in FBXW7-wildtype tumors leads to intrinsic drug resistance. Mechanistically, inactivation of FBXW7, the substrate recognition component of a SCF E3 ubiquitin ligase complex, stabilizes multiple oncoproteins especially Cyclin E and MYC, and antagonizes the cytostatic effect of Wnt inhibitors in these cancers. Moreover, although FBXW7 mutations do not mitigate β-catenin degradation upon Wnt inhibition, FBXW7 mutants instead lose dependence on β-catenin signaling, accompanied by dedifferentiation and loss of lineage specificity. These FBXW7-mutant Wnt/β-catenin-independent tumors are susceptible to multi-CDK inhibition by dinaciclib that targets both cell cycle and transcription. In summary, this study identifies FBXW7 mutations as a mechanism of Wnt independence and drug resistance in RNF43-mutant/RSPO-fusion cancers and reveals the potential of treating these cancers with multi-CDK inhibitors.

Citation Format: Zheng Zhong, David Virshup. Recurrent FBXW7 Mutations Bypass Wnt/β-catenin Addiction in Cancer [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr LT10.
Abstract P19: Comprehensive Benchmark of Somatic Mutation Callers on Cell-Free DNA Next-Generation Sequencing Data in Cancer Liquid Biopsy
Authors: Carrié Hanaé , Sim Ngak Leng , Wong Pui Mun , Gan Anna , Lau Yi Ting , Poon Polly , Thangaraju Saranya , Tan Iain , Yap Yoon Sim , Wong Limsoon , Skanderup Anders
Published: April 2024

Circulating tumour DNA (ctDNA) has emerged as a rich source of biomarkers in precision oncology. However, ctDNA sequence data is often noisier than that derived from standard tissue biopsies, posing significant challenges for accurate cancer mutation detection. Besides, there is a lack of standardised and unbiased benchmark datasets to evaluate and compare performance of variant callers on ctDNA. To address this issue, we present a novel benchmarking approach and comprehensive benchmark of cancer somatic mutation callers on cell-free DNA (cfDNA) Next Generation Sequencing (NGS) data.

To create a large-scale benchmark dataset, we developed a new methodology using real colorectal cancer patients plasma samples exhibiting either ultra-high and an ultra-low levels of ctDNA. This enabled the generation of dilution series of deep Whole Genome Sequencing (WGS, 150x) and the creation of high-quality consensus ground truth calls.

We evaluated the performance of 9 SNV callers and 7 short INDEL callers frequently used in academic research, including 2 callers that were specifically designed for cfDNA. We further validated our findings at higher depth of coverage using deep Whole Exome Sequencing (WES, >2,000x) data. We further investigated each caller's features to develop practical guidelines for users depending on their application setting: unguided analysis focusing on overall accuracy vs. guided analysis focusing on sensitivity.

Citation Format: Hanaé Carrié, Ngak Leng Sim, Pui Mun Wong, Anna Gan, Yi Ting Lau, Polly Poon, Saranya Thangaraju, Iain Tan, Yoon Sim Yap, Limsoon Wong, Anders Skanderup. Comprehensive Benchmark of Somatic Mutation Callers on Cell-Free DNA Next-Generation Sequencing Data in Cancer Liquid Biopsy [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr P19.