bluuebunny/crossref_metadata_2025 huggingface dataset:
“But when I come home…”: How patients with chronic musculoskeletal pain account for their absent pain during naturally occurring clinical consultations
Authors: Andersen Trine C.B. , Lian Olaug S.
Published: January 2025

When patients’ embodied experiences cannot be conveyed to clinicians in real-time, the challenges of reaching a shared understanding between patient and clinician are enhanced. In this study, we explore how patients with chronic musculoskeletal pain manage the situation of knowing that they regularly experience pain, yet exhibit minimal signs of it during clinical consultations. Utilizing a multimethod, conversation analysis approach and an interactional perspective, this paper analyzes 10 naturally occurring consultations at a specialized rehabilitation clinic in Norway. The analysis shows that patients account for the absence of pain by referring to i) specific events, ii) pain tolerance, and iii) pain periods. Such accounts were typically triggered by null findings (i.e., the absence of findings in technological and physical tests) in the physical examination and clinicians’ positive summaries of patients’ bodily conditions. Patients resist clinicians’ positive stance by accounting for absent pain, cautiously challenging the clinicians’ epistemic stance. If clinicians do not pursue patients’ accounts, this might lead to a misalignment between patient and clinician which can obstruct efforts to reach a shared understanding of the pain. These findings may have general relevance for clinical consultations where patients’ symptoms are difficult to measure and validate biomedically. Understanding how patients account for absent pain can enhance clinician-patient communication and improve clinicians’ understanding of patients’ everyday circumstances and thereby improve the outcome of consultations.
Dermatological Manifestations in Immunocompromised Pediatric Patients on Chemotherapy: A Cross-sectional, Observational Study
Authors: Rai Tulika , Mahawar Rajendra Kumar , Aggarwal Priyanka
Published: January 2025

Background:

Pediatric patients on chemotherapy suffer from various dermatoses due to immunosuppression or due to cutaneous adverse effects of chemotherapy. There is a paucity of literature from our country about the pattern of dermatoses in these patients.

Objectives:

This study has been conducted to know the pattern of dermatological manifestations in immunocompromised pediatric patients.

Materials and Methods:

All patients who attended the outpatient department of the division of pediatric hemato-oncology of our hospital and who were diagnosed with hematological and solid organ malignancy were screened. Those children whose guardians were willing to give consent and who fulfilled the inclusion and exclusion criteria were included in the study. The design of the study was cross-sectional. At the visit, demographic data, drug history, and history of any chronic disease were collected. The diagnosis of mucocutaneous manifestations was made by the dermatologist mainly on clinical findings. Special investigations such as potassium hydroxide mount for fungus and Tzanck smear were done in few patients when indicated.

Results:

A total of 76 patients were enrolled in the study. The ages of the patients ranged from 1 to 18 years with the mean age (years ± standard deviation) being 8.27 ± 4.24 years. A total of 8 patients (10.5%) had fungal infections. Ten patients (13.1%) had viral infections and six (7.9%) patients had bacterial skin infections. Generalized xerosis was the most common cutaneous manifestation which was seen in 13 patients (17.1%), followed by generalized hyperpigmentation, injection site reactions, and nevi (≤10 in number) in 10 patients (13.2%) each. In mucosal findings, mucositis was the most common manifestation seen in 13 patients (17.1%). In hair changes, anagen effluvium was the most common finding seen in 30 patients (39.5%).

Discussion:

Mucocutaneous findings are common in pediatric patients on chemotherapy. Prompt diagnosis and treatment reduce morbidity and improve the quality of life in these patients.

Conclusion:

Mucocutaneous findings are common in pediatric patients on chemotherapy due to cutaneous adverse effects of chemotherapy and immunosuppression.
Dermatitis Neglecta: A Case Series
Authors: Manjunath Sneha , Somaiah Savitha A , Subbarao Nagesh Tumkur
Published: January 2025

Dermatitis neglecta (DN) is a dermatological condition which occurs due to a lack of adequate cleansing of the skin. In DN, sebum, sweat, and keratin, along with dirt and debris progressively accumulate in a localized area of skin, resulting in the formation of hyperpigmented patch or a verrucous plaque, which can be cleared by rubbing vigorously with soap and water, or alcohol-soaked gauze. The condition is often underdiagnosed or misdiagnosed. Here, we present a case series of DN. There were a total of 30 patients in our case series of DN, with 13 male and 17 female patients, M:F: 1:1.3. The mean age of the patients was 30 ± 15.08 years and the mean duration of lesions was 2.5 ± 1.22 months. All the patients in our case series were asymptomatic, and there was a history of inadequate cleansing of the affected area in all of them. Predisposing factors such as verruca vulgaris, hypertrophic scar at the surgical site, depression, and anxiety were present in one patient each. Three patients had more than one site being involved, in the remaining 27 patients who had lesions localized to one site, the anterior trunk was the most common site of involvement. Out of 30 patients in our case series of DN, 28 were outpatients, and 2 were inpatients referred from other departments. In 20 (66.7%) of our patients, the lesions cleared on rubbing with saline-soaked gauze, and in 10 (33.3%) patients, the lesions cleared with the use of soap and water. DN, if diagnosed correctly, can be easily treated with soap and water cleansing.
Two Cases of Schimmelpenning Syndrome
Authors: Gulanikar Aniruddha , Gunreddy Aruna
Published: January 2025

Schimmelpenning syndrome is a rare variant of epidermal nevus syndromes that manifests with nevus sebaceous and multi-organ abnormalities. Here, we present two cases illustrating its diverse clinical manifestations. A 3-year-old girl has a large sebaceous nevus on her scalp and face, along with seizures and transient ischemic attacks. Examination and tests reveal coarctation of the aorta, eyelid colobomas, and other findings. The second case involves a 3-month-old girl with nevus sebaceous on her scalp and face. Tests and examinations showed she has an atrial septal defect and microcornea. A skin biopsy confirmed the diagnosis of nevus sebaceous. These cases emphasize the importance of thorough clinical examination and investigations in individuals with extensive nevus sebaceous. A review of the literature indicates that cardiovascular involvement in Schimmelpenning syndrome is relatively uncommon.
Clinico-Microbiological Profile of Urinary Tract Infections in Patients with Type 2 Diabetes: A Study Based in a Hospital Dedicated to Diabetes Care
Authors: Shaikh Suhail M. , Tiwari Shalbha , Purandare Vedavati B , Bhalekar Prashant , Bhake Ragini , Patil Neelam B , More Harshal P. , Unnikrishnan Ambika G.
Published: January 2025

Introduction:

People with diabetes are prone to urinary tract infections (UTIs). The inappropriate use of antibiotics can lead to the development of multidrug-resistant infections, prolonging patient recovery and significantly increasing healthcare costs. In a hospital focused on diabetes care, it becomes important to ascertain the clinical and microbiological profiles to develop appropriate institutional infection control protocols for managing such patients more effectively on an empirical basis; for this purpose, a pilot study was conducted through a representative sample.

Methods:

The study included randomly selected 60 patients with UTI: 25 patients were from the wards of the hospital and 20 patients were from the intensive care unit, of whom 10 had complicated UTI with multi-organ dysfunction. The remaining (n = 15) were from the outpatient clinic. Microbiological, and where possible, clinical parameters were studied.

Results:

The mean age of the subjects was 67.12 ± 9.84 years and the female-to-male ratio was 38: 22; 37 of the 38 women were postmenopausal. The mean duration of diabetes was 15.20 ± 7.93 years. Fifty subjects (83%) had an HbA1C >7%. Thirty-eight (63%) had recurrent UTI episodes. Four (6.7%) were on sodium glucose 2 transport inhibitors and estimated glomerular filtration rate (eGFR) was below 60 mL/min/1.73 m2 in 39 cases (65%). Escherichia coli was the most commonly isolated (59.7%), followed by Klebsiella pneumoniae (25.8%). Amikacin was the most effective antibiotic (86.7%), followed by imipenem, piperacillin–tazobactam, and meropenem. Eleven (18%) required ureteric stenting.

Conclusion:

In our study, people with diabetes have unique nature of UTI, characterized by predisposition to postmenopausal women, high need for urological procedures and a strong link to low eGFR, older age, long duration diabetes, and high HbA1C. Amikacin could be the choice of antibiotic on empirical basis for inpatient setting, whereas nitrofurantoin could be the preferred oral antibiotic. Taking cognizance of these results, the study emphasizes the need for specialized infection control programs and guidelines for diabetes care settings.
Effect of Vitamin D Supplementation on Serum Cytokines Level in Patients with Type 2 Diabetes Mellitus with and Without Foot Infection
Authors: Dwivedi Awanindra , Tiwari Shalbha , Pratyush Daliparthy D , Kishore Pratima , Singh Surya K.
Published: January 2025

Introduction:

Diabetic foot infections (DFIs) are a common and serious complication in individuals with diabetes mellitus. Low levels of Vitamin D have been proposed as a risk factor for diabetic foot and may be associated with cytokine dysregulation. This study aimed to evaluate the effect of Vitamin D supplementation on circulating levels of tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in Type 2 diabetes mellitus (T2DM) patients with and without foot infections.

Methods:

T2DM patients with and without foot infections were enrolled as cases and controls. Both groups were supplemented with a total 300,000 IU oral dose of Vitamin D. Serum concentrations of 25 (OH) Vitamin D and cytokines (TNF-α, IL-6) were measured in both groups at baseline and follow-up using radioimmunoassay and enzyme-linked immunosorbent assay, respectively.

Results:

Serum concentrations of 25 (OH) Vitamin D significantly increased in both groups (cases: P <0.0001; controls: P =0.012). The difference in mean (±standard deviation) levels of circulating serum inflammatory cytokines, TNF-α and IL-6, at baseline and follow-up was not significant in controls but was significant in cases (TNF-α: P =0.0001; IL-6: P =0.0026).

Conclusion:

Vitamin D supplementation, particularly a high dose (60,000 IU/week) for a short period (5 weeks), significantly reduces inflammatory cytokines TNF-α and IL-6 in patients with DFI, supporting its beneficial role in managing inflammation.
Effect of mindfulness-based stress reduction therapy on liver functions in a symptomatic patient of primary biliary cholangitis: A case report
Authors: Arora Chetna
Published: January 2025

A 44 year old married woman was diagnosed with Primary Biliary Cholangitis in Sep 2022. Currently symptoms as described by the patient began in Jan 2024 with weakness, easy fatigability, lethargy, irritability and generalised itching for 3−4 weeks. History of work related stress and family stress was there. The patient was on regular medication since Sep 2022 as prescribed by the Gastroenterologist. The patient was put on Mindfulness Based Stress Reduction Therapy (MBSRT) for 4 weeks in Mar 2024 in addition to the conventional medication with no change in dosage of medication. The results of this study showed a significant reduction in all liver function tests (LFTs) with complete disappearance of symptoms after 4 weeks of MBSRT. It suggests that Mindfulness Based Stress Reduction Therapy can be utilised as an effective adjunct to the conventional pharmacological interventions in a symptomatic patient of Primary Biliary Cholangitis with deterioration of LFTs.
Unveiling a TGFBI Variant in the Retinal Capillary Hemangioblastoma, Type II Granular Corneal Dystrophy, and Von Hippel–Lindau Families: Unlocking Potential for Early Intervention and Targeted Therapy
Authors: Azimi Fatemeh , Khakpour Golnaz , Sedaghat Ahad , Mostafaiee Fatemeh , Kasraei Hengameh , Naseripour Masood
Published: January 2025

Purpose:

To identify the potential genetic factors responsible for retinal capillary hemangioblastoma (RCH) and Type II granular corneal dystrophy (GCDII), with autosomal dominant inheritance. We used whole-exome sequencing (WES) in an Iranian family to identify the possible genetic etiology of RCH and GCDII with other manifestations of von Hippel–Lindau (VHL) disease.

Methods:

This study included one Iranian family for WES in index patients and Sanger sequencing in all available individuals.

Results:

Clinical presentations of these patients included RCH, GCD, central nervous system hemangioblastoma as well as pancreatic cyst. WES disclosed a heterozygous known pathogenic variant c.371G>A (p.R124H) in exon 4 of gene TGFBI.

Conclusions:

For the first time, our research identified the potential involvement of TGFBI: c.371G>A (p.R124H) in an Iranian family with RCH, GCDII, and other symptoms of VHL disease. In the future, TGFBI could offer a new understanding and a promising therapeutic approach for both GCDII and VHL diseases simultaneously. Before using the variant in genetic counseling, it is recommended to conduct functional analysis using appropriate animal models to understand its pathogenesis mechanism.
Review of published case reports on diagnostic and therapeutic approach of chronic kidney disease through Ayurveda: A scoping review
Authors: Upadhyay Shushma , Pandey Yogesh Kumar
Published: January 2025

BACKGROUND:

The conceptual model of chronic kidney disease (CKD) was created by the National Kidney Foundation-Kidney Disease Outcomes Quality Initiative in 2002 and was later amended and adopted by an international consensus under the auspices of Kidney Disease Improving Growth Outcome (KDIGO) in 2005. The clinical presentation of CKD is defined by KDIGO as structural and functional abnormalities found in the kidney for at least 3 months, with or without decreased glomerular filtration rate (GFR), and may include abnormalities in the composition of blood or urine. CKD coexists with hypertension and diabetes mellitus, cardiovascular disease and is recognized as a risk factor for all. There is no reference of Vrukka Roga in ancient sources except “Vrukka Roga Chikitsa” mentioned in Bhaishajya Ratnavali as Parshisht Adhyaya, but the clinical presentation of CKD is similar to that of Mutravaha Sorotas Dusti. Several herbs are described for treatment of Mutravaha Srotas Dusti, which work as Mutrala (diuretics), Shothahara (anti-inflammatory), Pramehahara (anti-diabetic), and Basti Shodhak (cleanses the urinary bladder).

MATERIALS AND METHODS:

A review of published articles was planned to explore the effect of Ayurvedic management in improving renal function, hemoglobin levels, blood pressure, glycemic control, and other parameters in CKD. A comprehensive literature search of case studies spanning 8 years was conducted using Google Scholar, Web of Science, Scopus, and Index Copernicus. The studies that fulfilled the inclusive criteria were included in the review.

RESULTS:

Out of 35 identified case reports, 23 met the inclusion criteria for analysis. The mean age of the subjects was 51.58 years, with 70% males and 30% females. Following Ayurvedic treatment, notable improvements were observed in serum creatinine (Sr. Cr), serum urea, and hemoglobin levels (Hb%). However, only five case reports utilized the diagnostic criterion of estimated GFR (e-GFR), which showed significant improvement. There was no evidence to suggest the impact of herbal formulations on blood pressure, fasting glucose, serum electrolytes, or other related parameters.

CONCLUSION:

This scoping review suggests that Ayurvedic management shows potential benefits in CKD, with observed improvements in Sr. Cr, blood urea, Hb%, and e-GFR in a subset of studies. The data of the studies also demonstrate that the Ayurvedic interventions have potential in alleviating CKD-related symptoms. However, the few studies, inconsistencies in methodology, and lack of standardized diagnostic criteria underscore the need for large-scale, high-quality clinical trials to confirm these findings and establish the efficacy and safety of Ayurvedic formulations in CKD management.
Potential therapeutic applications of medical gases in cancer treatment
Authors: Bazzal Abbas Al , Hoteit Bassel H. , Chokor Mariam , Safawi Abdallah , Zibara Zahraa , Rizk Fatima , Kawssan Aya , Danaf Naseeb , Msheik Layal , Hamdar Hiba
Published: January 2025

Medical gases were primarily used for respiratory therapy and anesthesia, which showed promising potential in the cancer therapy. Several physiological and pathological processes were affected by the key gases, such as oxygen, carbon dioxide, nitric oxide, hydrogen sulfide, and carbon monoxide. Oxygen targets shrinking the tumor via hyperbaric oxygen therapy, and once combined with radiation therapy it enhances its effect. Nitric oxide has both anti- and pro-tumor effects depending on its level; at high doses, it triggers cell death while at low doses it supports cancer growth. The same concept is applied to hydrogen sulfide which promotes cancer growth by enhancing mitochondrial bioenergetics and supporting angiogenesis at low concentrations, while at high concentrations it induces cancer cell death while sparing normal cells. Furthermore, carbon dioxide helps induce apoptosis and improve oxygenation for cancer treatments by increasing the release of oxygen from hemoglobin. Moreover, high-dose carbon monoxide gas therapy has demonstrated significant tumor reductions in vivo and is supported by nanomedicine and specialized medicines to boost its delivery to tumor cells and the availability of hydrogen peroxide. Despite the promising potentials of these gases, several challenges remain. Gas concentrations should be regulated to balance pro-tumor and anti-tumor effects for gases such as nitric oxide and hydrogen sulfide. Furthermore, effective delivery systems, such as nanoparticles, should be developed for targeted therapy.
A Cross-Sectional Study on Status of Contralateral Ear in Cases of Unilateral Chronic Otitis Media Mucosal Type of Disease
Authors: Buruhanudeen Sameera , Rajasekaran Valli , Pandian Manoj
Published: January 2025

ABSTRACT

Context:

The contralateral ear may be experiencing chronic otitis media (COM) at different stages or without an active symptom, and therefore, it is doubtful that the COM in one ear will have any impact on it.

Aim:

The study aimed to determine the status of contralateral ear in cases of unilateral COM mucosal type of disease.

Settings and Design:

A cross-sectional study was conducted with 45 patients in a tertiary care center over 18 months.

Materials and Methods:

The patients between 18 and 60 years with unilateral mucosal COM were included in this study. All patients underwent otoscopy, pure tone audiometry (PTA), impedance, X-ray mastoid, and high-resolution computed tomoghraphy (HRCT) temporal bone evaluation for both ears.

Statistical Analysis:

The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 22. Descriptive statistics was used to describe the findings in the contralateral ear.

Results:

The mean age of patients was 39.53 ± 13.64 years. Males and females were almost equally involved. Middle ear pressure changes were seen in eight (17.8%) of patients. Type A tympanogram was seen in 82.2% of contralateral ears, and the remaining showed type C. A total of 17.8% and 13.3% had pars tensa and pars flaccida retraction. Conductive hearing loss (CHL) was seen in 86.7%. Mastoids were well-pneumatized in 82.2% of patients, and 2% had ossicular erosion. No changes were seen in the Eustachian tube (ET) angle.

Conclusion:

The majority of the people had conductive hearing loss in the contralateral ear. The changes in the middle ear pressure and tympanic membrane retractions were also noted. Hence, we recommend mandatory evaluation of contralateral ear in COM (mucosal type) cases even if they are asymptomatic.
Clinicopathological Presentation, Prognosis, and Overall Survival of Primary Extra Nodal Lymphomas
Authors: Ghongade Pravinkumar , Patil Bharat Umakant , Gupta Anupama , Gangane Nitin M.
Published: January 2025

ABSTRACT

Introduction:

Primary extranodal lymphoma (PENL) originates from extranodal organs or tissues. Approximately 25–40% of NHL arise primarily from sites other than lymph nodes.

Material and Methods:

A retrospective study where survival outcome was calculated using the Kaplan–Meier method. Prognostic factors were estimated using the Cox proportional hazard regression model.

Results:

Out of 228 non-Hodgkin lymphoma (NHL) cases, 97 (42.54%) cases were presented as PENL. Head and neck (31.95%) were the most common site of PENL, followed by the gastrointestinal tract (24.7%) and soft tissue and bone (10.3%). The overall survival (OS) in PENL was 72.1%, while in nodal NHL, the overall survival was 47% at three years. The median survival for PENL was 1737.21 days, with a standard error of 155.31 days. Survival outcome, from KM method, analysis of PENL had a significant association with anatomical location (P = 0.022), given treatment modality (P = 0.000), and histopathological grading (P = 0.004). Associated factors of mortality from the multivariable analysis were noted as high-grade lymphoma histologically (P = 0.011) (Hazard ratio (HR) =3.112, 95% CI 1.592-6.889), T-cell lymphoma (HR = 1.887, 95% CI 0.893-4.121), single line treatment and no treatment (P = 0.028) (HR = 2.728, 95% CI 1.289-3.184), and age of patients >51 years. (HR = 1.772, 95% CI 0.86-3.297) (P = 0.041).

Conclusion:

The median survival for PENL was significantly better than nodal NHL. Prognostic factors such as age >51 years, single modality treatment T-cell lymphoma, high-grade lymphoma, and nodal lymphoma are associated with poor survival.
Immunohistochemical Study of Ki-67 and HER2/neu and its Correlation with Clinicopathological Features in Surface Epithelial Tumors of the Ovary
Authors: Alva Sameeksha , Pallipady Aravind
Published: January 2025

ABSTRACT

Background:

Worldwide, ovarian cancer is the sixth most common cancer and seventh most common cause of cancer death. Most of the ovarian cancers have spread beyond the ovary by the time of diagnosis; they account for a disproportionate number of deaths from cancer of the female genital tract. Ki-67 is one of the prognostic markers which determine the growth fraction of a tumor, and its overexpression is associated with malignancy, tumor aggression, prognosis, and metastasis. Overexpression of HER2/neu is most commonly observed in the breast, gastric carcinoma, lungs, and ovaries.

Material and Methods:

The study is conducted at the central diagnostic laboratory of the Pathology department at A.J. Institute of Medical Sciences and Research Centre, Mangalore. This was a 24 months prospective study. Hematoxylin and eosin sections were studied, and Ki-67 and HER2/neu immunohistochemistry was done.

Results:

A total of 61 cases were studied. Serous carcinoma (31%) was the most common type of tumor found in our study. The current study shows significant association between nature of tumor and KI 67 with Chi square value = 52.820 with P < 0.001. There was no significant association between the grade of differentiation and Ki-67 index, with P = 0.78. The association between the tumor staging and Ki-67 did not show any significance, with Chi-square = 21.574 and P value = .272. HER2/neu did not show any association with tumor grade, size, staging, and other variables. 100% of cases were tested negative in this study.

Conclusion:

High Ki-67 expression was associated with a malignant group of tumors. HER2/neu did not show any association in the current study as 100% cases were negative. Further investigation of HER2/neu with ISH method is necessary to rule out false negative results.
Posterior Microphthalmos Accompanied by Papillomacular Folds and High Hyperopia
Authors: Goli Kalpita , Mushtaq Iqra , Magdum Renu , Giri Nilesh
Published: January 2025

ABSTRACT

Microphthalmos is an uncommon developmental condition characterized by significantly smaller eyes than average, with an axial length that is at least two standard deviations lower than normal for the individual’s age group. This condition is quite uncommon, with a birth prevalence of only 0.002–0.017%. Posterior microphthalmos is a clinical entity that presents as shortened eyeball, but the shortening is confined to the posterior segment. The patient generally presents with high hypermetropia with or without convergence squint. Detecting posterior microphthalmos requires specific investigations like optical coherence tomography. There are only a few cases of posterior microphthalmos that have been documented until today.
О практической безопасности ключа
Authors: Drelikhov V O
Published: January 2025

Рассмотрены достаточные условия для отклонений вероятностной модели генерации ключей от равномерного распределения вероятностей, при которых ключи остаются надежными в криптографических приложениях.
Criteria for $C^m$-approximability of functions by solutions of homogeneous second-order elliptic equations on compact subsets of $\mathbb{R}^N$ and related capacities
Authors: Mazalov Maksim Yakovlevich , Paramonov Petr Vladimirovich , Fedorovskiy Konstantin Yurievich
Published: January 2025

Results of the last 12 years obtained by the authors and their co-authors are discussed. The main achievement of this period of time was establishing Vitushkin-type criteria in terms of capacities for the $C^m$-approximability of functions by solutions of homogeneous elliptic equations of the second order, with constant complex coefficients on compact subsets of $\mathbb R^N$, in all dimensions $N\in\{2,3,…\}$ and for all smoothness exponents $m\in[0,2)$. These criteria are stated for individual functions. They yield directly the relevant criteria for classes of functions established previously by Mateu, Orobitg, Netrusov, and Verdera (1996, apart from $m=0$ and $m=1$). Another significant result established during these years was an integro-geometric description of all capacities arising in these criteria in the cases $m=0$ (Mazalov, 2024) and $m=1$ (Tolsa, 2021). In particular, these capacities were shown to be subadditive.
Bibliography: 69 titles.
Long-Distance Cavernous Flow in the Upper Florida Aquifer, Woodville Mantled-Karst Plain, Leon and Wakulla Counties, Florida
Authors: McGlynn Seán , Niedoroda Alan
Published: January 2025

A Rhodamine WT dye study was conducted to establish whether a subterranean flow could be positively demonstrated between Lake Jackson, a shallow perched lake, and Wakulla Spring, a renowned first magnitude spring. The lake is 30.6 km north of the Spring and 8 km north of Tallahassee, Florida. Dye was injected into a lake-bottom sinkhole on September 19, 2017, for 6.5 min. The main distinctive dye concentration peaks were recorded by sondes located at both Wakulla Spring and nearby Sally Ward Spring after 35 days. Charcoal packs deployed at these two springs and three others nearby also encountered dye within time intervals consistent with the recorded breakthrough events measured by the sondes, all of which were of short duration ranging from 1 min to 100 min. These results indicate that some of the injected dye made its way to several Wakulla County springs via an aquifer conduit-like system dominated by advection within which water flowed at an average speed of 0.8 km d−1. Dye detection at five well-separated springs further indicates that the conduit system is both braided and branching. Although these results show a connection between Lake Jackson and several Wakulla County springs and point to a leaky-conduit flow able to transport nutrients and pollutants rapidly over long distances, another important conclusion of the study is that, overall, very little of the dye injected into the lake-bottom sinkhole made it to Wakulla Spring. This indicates that most of the dye dispersed into the limestone matrix. This study has been exploratory in design and only allows conjectural statements on the actual dye-mass balance
Cave Monitoring in the Monsoon Region of China and Its Paleoclimatic Implications
Authors: Tian Yiping , Guang Kaiyue , Li Jiayan , Zhu Shanying , Tian Lijun , Li Yunxia , Gao Yongli , Rao Zhiguo
Published: January 2025

Cave monitoring is essential for accurately interpreting the significance of proxies in stalagmite records. Here, we have compiled published monitoring data from 14 caves in the monsoon region of China (MRC), including cave air temperature (Tin ), cave air relative humidity (RH), cave air CO2 concentration (PCO2 ), multiple proxies (δ18O, δ13C, Trace element (TE)/Ca) in drip water and associated modern calcite, to serve as a reference for the stalagmite paleoclimate studies. The seasonal variations in these monitoring parameters were demonstrated through a carefully selected 24-month observation period at the cave sites. The seasonal variations in Tin , RH, and cave air PCO2 mainly depended on the local climate conditions and the degree of cave ventilation or tourist activities. Furthermore, the type and degree of ventilation were regulated by the site-specific karst structure system, such as the size of fractures, fissures, entrances and their relative altitude. The spatial-temporal variations observed in the behavior of δ18O, δ13C and TE/Ca in drip water and modern calcite can be attributed to the unique processes and environment prevailing within each cave. These in-cave processes and environment, including prior calcite precipitation (PCP), incongruent calcite dissolution (ICD), water-rock interaction (WRI), evaporation, drip rates, and calcite growth rates, are intricately related to the surface climate or hydrological conditions. Before applying geochemical proxies in stalagmites to paleoclimatic reconstruction, it is essential to ascertain the response mechanism of these geochemical proxies to those in-cave processes and surface climate or hydrological conditions, in addition to the replication test. More comprehensive cave monitoring studies with systematic design and longer durations are necessary for improving interpretations of proxies preserved in stalagmites.
Revista Completa Derecho UCT
Authors: Universidad Católica de Trujillo
Published: January 2025

ARTÍCULOS
1. Afectación Jurídica a los Derechos Fundamentales por la devolución del Presupuesto Público
    Legal Impact on Fundamental Rights by the Return of the Public Budge
2. El Derecho Agrario en Cuba desde una perspectiva sociocultural, las leyes de la reforma Agraria de 1959 y 1963
    Agrarian law in Cuba from a sociocultural perspective, the Agrarian Reform laws of 1959 and 1963
3. ¿Extorsión, un laberinto sin salida?: Modalidades más empleadas en Alto Trujillo
    Extortion, a labyrinth without exist? Most used modalities in Alto Trujillo
4. Los Procesos de Tutela de Derechos y las insuficiencias de la Jurisdicción Constitucional Peruana
    The Processes of Protection of Rights and the insufficiencies of the Peruvian Constitutional Jurisdiction
5. El machismo una epidemia en las sombras de las familias trujillanas, 2022
    Machism an epidemic in the shadows of trujillana families, 2022
Revista Completa Derecho UCT
Authors: Universidad Católica de Trujillo
Published: January 2025

ARTÍCULOS
Aspectos problemáticos en la admisión de medios extemporáneos en el Proceso Civil Peruano
Problematic aspects in the admission of extemporanean means in the Peruvian Civil Process
Evaluación de la eficiencia del proceso inmediato en casos de flagrancia delictiva en Perú, una revisión sistemática
Evaluation of the efficiency of the immediate process in cases of criminal flagrancy in Peru, a systematic review
Problemática del despido incausado en el Perú
Problem of uncaused dismissal in Peru
Factores que inducen a funcionarios públicos para la comisión del delito de peculado, Red de Salud Coronel Portillo, 2023
Abstract factors that induce public officials to commint the crime of embezzlement, Coronel Portillo health network, 2023
Fundamentos de control en las pensiones alimenticias de menores de edad del Distrito Judicial de La Libertad, 2023
Fundamentals of control in the support of minors, of the Judicial District of La Libertad, 2023
Seismic Performance Assessment of RC Buildings with Variable Soft Storey Configurations and Infill Masonry Using Nonlinear Pushover Analysis
Authors: Dahal Niroj , Adhikari Bishal , Thapa Deepak , Devkota Dibbya , Arayal Sushma
Published: January 2025

Reinforced Concrete (RC) buildings with infill masonry walls are a prevalent construction practice in seismically active regions such as Nepal. However, rapid population growth has driven a surge in residential construction, often bypassing essential design considerations, including seismic safety. This oversight leaves many buildings susceptible to significant damage, even during low-intensity ground shaking. A critical factor influencing a building's seismic performance is the presence and placement of soft stories floors that are comparatively weaker or more flexible than others in the structure. These soft storeys can dramatically affect structural behavior during seismic events.
Structural engineers frequently resort to increasing the dimensions of beams and columns to address these vulnerabilities. While this approach enhances structural capacity, it often results in inefficient and overly conservative designs. This study evaluates the seismic performance of RC buildings with varying soft storey levels and in fills masonry configurations through nonlinear pushover analysis using finite element simulations. The analysis compares bare frames, structures with different percentages of infill masonry, and fully infilled models.
Key structural responses analyzed include base shear, performance points, deflection, storey drift, and hinge formation stages. The results reveal that increasing the quantity of infill masonry enhances performance points and base shear while reducing displacement. Storey drift ratios displayed sharp peaks at certain levels, followed by reductions. Capacity curves for frames with 25%, 50%, 75%, and 100% infill illustrated considerable variations in structural response. Fully infilled frames demonstrated higher base shear capacities but reduced roof displacements at the collapse stage compared to partially infilled frames.
These findings underscore the critical role of infill masonry quantity and soft-storey positioning in seismic design. By addressing these factors, engineers can achieve a more effective balance between structural safety and design efficiency in reinforced concrete buildings.
Innovations in the agro-industrial complex: strategy and growth reserves
Authors:   Al-Farabi Kazakh National University, Dauliyeva G. R. , Yerezhepova А. А. ,   Al-Farabi Kazakh National University, Utebayeva Zh. А. ,   A.Baitursynov Kostanay Regional University
Published: January 2025

The aim is to substantiate the importance and economic necessity of digital processes in the agro-industrial complex as a factor of innovation and investment growth, to develop practical recommendations for the optimal use of digital solutions for sustainable development of the agrarian industry.

Methods - economic-mathematical, correlation-regression - in the study of statistical data, determining trends in increasing the capacity of agriculture, conducting a quantitative analysis of the impact of digital transformation on the efficiency of agro-industrial production, identifying the problems of introducing high-efficiency technologies in the agricultural sector.

Results - so far the agrarian sector in Kazakhstan and globally has not been attractive to the market economy, mainly due to high risks and difficulties with forecasting. However, with the emergence of innovative structures and new opportunities such as digital modernization, the volumes of attracted investments are increasing. In Asia, about 20 % of emerging agribusinesses
are related to innovation. The effect of digitalization of agribusiness is expected to be about 30 % of GDP growth, which is planned to reach over 3 trillion tenge by the beginning of 2030. The modern agro-food market is a high-tech segment. Land and climate are no longer determinants of the success of agrarians, innovative tasks come to the fore.

Conclusions - the directions for increasing innovation activity and productivity in the agro-industrial complex are proposed. The authors note that the main goal of scientific support of innovation activity is the application of resource saving, environmentally safe and economically efficient nanotechnologies for optimization of genetic resources - productivity of crops and animals, improvement of breeding methods, development of energy-intensive equipment and information and communication systems. Initiatives implemented with state support for innovative projects include the Supervision Technologies platform for digital land monitoring, agro-insurance service, and electronic trading platform.
Material and technical support of agricultural formations of the Republic of Kazakhstan: stimulation of innovation and investment processes
Authors:   Kazakh Research Institute of Economy of Agro-Industrial Complex and Rural Development, Ibrishev N. N. , Zhumasheva S. Т. ,   Kazakh Research Institute of Economy of Agro-Industrial Complex and Rural Development, Tatikova А. U. ,   Kazakh Research Institute of Economy of Agro-Industrial Complex and Rural Development
Published: January 2025

Relevance - innovation and investment development of agro-industrial complex, based on modernization of technical equipment of the industry, introduction of digital technologies on the basis of investment inflow allows to increase labor productivity and produce competitive products.

Aim - development of theoretical and methodological substantiation and practical recommendations on public investment of innovation activity in agriculture as a basis for improving the efficiency of the agrarian sector of Kazakhstan.

Methods - system analysis of results to identify trends and effects, statistical - in the study of the obtained data, economic approach - to assess and forecast the results of economic activity, to determine its positive and negative directions and optimize production processes.

The results - lack of modern agricultural machinery, insufficient level of rural infrastructure renovation and limited access to the market, low degree of replenishment of fixed assets of enterprises, wear and tear of machinery and equipment, lack of capital investment due to seasonal work and high risk for investors have become the main obstacles to sustainable growth of agro-industrial production. The authors consider the issues of rational construction of material and technical base, financing in the field of crop production and increase in gross output, confirmed by a strong positive relationship. The reasons preventing the realization of innovative activity of enterprises in many economic segments of the republic are outlined. Using the generalized official data on material and technical resources, the dynamics of depreciation and liquidation of fixed assets of agro-industrial complex is analyzed.

Conclusions - the authors recommend increasing investment in the use of environmental and "green" technologies, implementation of training and consulting programs for farmers on advanced technologies and innovations, leasing financing, partnership with research institutes to share knowledge and experience. Joint research and experiments should become the main tools of state support for innovative and investment development of crop production.
Queer, Neurodivergent Access Intimacy
Authors: Savard Nicolas Shannon
Published: January 2025

This audio essay uses director Nicolas Shannon Savard's experimental approach to ensemble-based audio description in a 2023 production of JC Pankratz's Seahorse as the starting point for investigating where intimacy direction, disability aesthetics, and queer storytelling overlap. Reflections from both the director and actors involved in the production aim to model possibilities for how consent-based, trauma-informed practices can foster access intimacy in the rehearsal room and open up additional pathways to nuanced, fully human portrayals of queerness, neurodivergence, and madness on stage. The case study is framed by a discussion with disability and performance scholar Katya Vrtis, exploring the broader implications of access intimacy as an approach to creating more human-centered artistic and academic spaces.
ETIČNOST GOVORNIKA SA POSEBNIM OSVRTOM NA POLITIČKE GOVORNIKE
Authors:   University of Kragujevac, Faculty of Law, Serbia, Mrđenovic Ksenija
Published: January 2025

Centuries ago, the importance of ethics is evidenced by the works of great
philosophers. Its general presence indicates the importance of existence in every
society, country and time. In moments when it seemed that ethics was disappearing, it
always returned to the big door and was an important topic of the state, society, but
also of every healthy individual. It found a special application in the field of rhetoric as
an important link between speakers and listeners with the aim of shaping social
perception and moral values. This paper highlights the importance of ethics itself for
listeners and speakers, with special reference to the ethics of political speakers. The
work also aims to develop critical awareness among listeners and explains the
importance of implementing ethical standards in the personality of the speaker himself,
all with the aim of contributing to a healthier social environment and political order. In
addition to the above, the paper will discuss the role of manipulation, as well as the
speaker's responsibility towards the audience.
KARAKTERISTIKE NOVOG JAVNOG MENADŽMENTA U AUSTRIJI
Authors:   University of Kragujevac, Faculty of Law, Serbia, Jovanović Zoran
Published: January 2025

n the subject paper, all the most important specificities and characteristics of
the new public management that distinguish Austria, as a product of the federal state,
will be pointed out. On this occasion, at the very beginning, the territorial
arrangement of the state of Austria will be determined because it is of essential
importance for further understanding of the operation of the public service.
Furthermore, the author will put special emphasis on the political structure of the
state of Austria, through the clarification of the basic components that make it up. The
basis of the article will be the determination of the basic principled positions related
to the functioning of the public service, by which the author will, first of all, engage in
the presentation of the historical development of the reforms that characterized the
public service, and then elaborate the basic characteristics of the new public
management in Austria with the perspectives that, in connection with her, we can
expect in the future. A comparative-legal review of the state of the new public
management in selected countries of the world will also be made, in order to see the
advantages and disadvantages of the new public management in Austria.
Pengaruh Budaya Organisasi Opmaz terhadap Perubahan Perilaku pada Santri Kelas 12 Ma Ma'had Al-Zaytun
Authors: Asyidda Najibullah Zahra , Muhammad N. Abdurrazaq  , Sobirin
Published: January 2025

This study aims to: (1) whether or not there is a relationship between OPMAZ organizational culture and behavioral changes in grade 12 students of MA Ma'had Al-Zaytun; (2) the influence of OPMAZ organizational culture on behavior changes in grade 12 MA Ma'had Al-Zaytun students as administrators and non-administrators of the organization. The research method used is a quantitative approach with the theory used in this study being Robbins (1996) theory, namely organizational culture and behavior change theory. A simple linear regression test was used in the study to determine the influence, and the determination coefficient (R2) was used to determine the percentage of influence on the number of samples of 76 respondents and a total population of 579. The results of the study show that: First, there is a positive relationship between OPMAZ organizational culture and changes in student behavior, which is evidenced by the value of the determination coefficient (R²) of 0.485 or 48.5%, which shows that around 48.5% of the variability of student behavior changes can be explained by variations in OPMAZ organizational culture. Second, a simple linear regression test revealed that OPMAZ organizational culture had a significant influence on changes in student behavior, with a regression equation of Y = 0.6964X and then Scatter Plot analysis with the Standardized Coefficients method showed a strong positive linear relationship between the two variables. Based on the results of the analysis, the change in student behavior was categorized into 4 quadrants actually and 2 quadrants based on regression results, which showed the similarity of the level of organizational culture and changes in student behavior from sufficient to good.
Implantes imediatos em áreas estéticas. Revisão de literatura
Authors: Cunha Gustavo Tavares Barbosa e
Published: January 2025

O objetivo deste artigo foi avaliar as taxas de sobrevivência e sucesso de implantes imediatos em áreas estéticas. Essa temática se faz importante pois pode trazer melhorias na técnica e influenciar em maior autoestima e bem-estar aos pacientes. Para a realização deste estudo foi feita uma revisão integrativa de literatura.  Assim, foram realizadas pesquisas nas bases de dados Scientific Electronic Library Online (SciELO), Biblioteca Virtual em Saúde (BVS) e Medical Literature Analysis and Retrieval System Online (MEDLINE via PubMed), utilizando as seguintes palavras-chave: “implantes dentários”, “implantes imediatos” e “estética” ou “dental implants”, “immediate implants” e “aesthetic”. Foram incluídas no estudo, publicações relacionadas à temática, publicadas entre 2016 e 2021 em português ou inglês e disponíveis na íntegra. Com o estudo foi possível concluir que a colocação de implantes imediatos oferece muitas vantagens para o paciente e o clínico, mantendo a altura dos tecidos moles peri-implantar e aumentando a densidade óssea peri-implantar. Ainda, a carga oclusal imediata pode estar associada a reduções na dor do paciente, tempo de procedimento, e redução na quantidade de material a ser utilizado.
Abordagens e condutas ortodônticas para verticalização de molares
Authors: Leonel Letícia Pereira , Melo Eduardo Henriques de , Miranda Amanda Galindo Florêncio
Published: January 2025

Realizar uma revisão de literatura acerca das abordagens e condutas ortodônticas com vistas a verticalização de molares. A busca dos artigos da revisão foi realizada de forma digital, nas bases de dados Biblioteca Virtual em Saúde, Scientific Electronic Library Online e Google Acadêmico, utilizando os seguintes descritores: impactação dentária; verticalização dentária; técnicas de movimentação dentária; procedimentos de ancoragem ortodôntica; dente impactado; tração. Foram incluídas publicações relacionadas aos objetivos elencados nesta pesquisa, artigos nos idiomas português ou inglês, disponíveis em texto integral. Foram excluídos artigos em duplicidade. O desenho mais recorrente das publicações foi de estudos de revisão, relatos de casos e ensaios clínicos prospectivos. Duas principais vias para verticalização foram predominantes. A primeira, por meio de outros dentes como ancoragem, e a segunda, pelo emprego de dispositivos temporários de ancoragem esquelética extra-alveolar. Dentre as medidas para aumentar a previsibilidade e a estabilidade dos casos, a literatura revisada destacou o uso de múltiplas abordagens no mesmo paciente, em especial o emprego concomitante de alinhadores e mini-implantes. Esta última foi citada como sendo de melhor controle em relação aos efeitos indesejáveis.