bluuebunny/crossref_metadata_2025 huggingface dataset:
Dominant Factors of Positive Impact of Ownership of Work Competency Certificate in Craftsman' Perception
Authors: Darussyafa Huda , Widiasanti Irika , Anisah
Published: September 2020

This study aims to determine the dominant factor of the positive impact of ownership of work competency certificates in the perception of artisan on highrise building projects in the city of South Jakarta. Based on existing data the number of workers who already have work competency certificates is still very minimal. That is caused by several factors, namely the process of implementing certification which is considered complicated to the cost which is considered expensive. But behind these constraints, work competency certificates can have a positive impact on construction workers who have them. In this study conducted by quantitative methods by analyzing the percentage of respondents' perceptions. This research was carried out on the Cithaland Tower project, Alamanda Tower, Dharmawangsa Office Tower. The total number of respondents to be studied is 44 people. In this study the dominant factor studied was measured through four indicators namely work motivation, work productivity, work ability and competitiveness. With each percentage acquisition namely for Work Motivation 26.44%, Work Productivity 24.40%, Work Ability 24.66%, and Competitiveness 24.50%. Of the four indicators there is one indicator with the highest percentage and is the most dominant factor, namely the Work Motivation indicator with a percentage of 26.44%.
Evaluasi Program Praktik Kerja Lapangan Program Studi D3 Teknologi Konstruksi Bangunan Gedung Fakultas Teknik Universitas Negeri Jakarta
Authors: Lenggogeni Lenggogeni
Published: September 2020

Penelitian ini bertujuan untuk mengetahui kesesuaian implementasi program magang di Program Studi Diploma Teknologi Konstruksi Bangunan, Fakultas Teknik, Universitas Negeri Jakarta, termasuk 1) perencanaan, 2) implementasi dan 3) hasil tes praktik siswa dengan standar objektif. Penelitian ini juga bertujuan untuk mengetahui hambatan-hambatan yang dialami oleh siswa dalam pelaksanaan magang dan mencari tahu hal-hal yang mendukung pelaksanaan program. Metode yang digunakan dalam penelitian ini adalah model evaluasi Countenance Stake. Model ini mencakup evaluasi Anteseden, Transaksi, dan Output. Data dalam penelitian ini berasal dari kurikulum, administrasi, dan responden siswa yang mengambil magang pada 2018/2019. Berdasarkan hasil evaluasi, program memenuhi aspek perencanaan dan implementasi yang memenuhi standar. Pada tahap evaluasi, 62,07% siswa menerima nilai kumulatif A-. Dari jumlah ini, para peserta dapat memahami semua materi dengan 81% hingga 85%. Skor umpan balik adalah 4, yaitu, siswa memahami kompetensi spesifik yang diperoleh selama magang.
Peningkatan Kompetensi Menggambar 3D Sketchup Melalui Project Based Learning Dengan Tutor Sebaya
Authors: Jatmikowati
Published: September 2020

This study aims to improve students' scores and skills in the subjects of Software Application and Building Interior Design. The implementation of this classroom action research consisted of two cycles (cycle I and cycle II) with each cycle having two meetings. Students carry out project-based learning; that is, students directly practice drawing by the job sheets provided. The role of the peer tutor here is to assist the teacher in guiding students in completing the project, accompanied and directed by the teacher. The results obtained showed that in the first cycle, the student activeness aspect reached an average of 76% (Enough Active) and the achievement of the knowledge value was 17.1% of competent students. In comparison, the achievement of skill scores was that 25.7% of students were competent with KKM (Maximum Completeness Criteria ) 76. In the second cycle, there was a significant increase with student activeness increasing to an average of 86% (Active), while the achievement of the knowledge score increased to 91.43% of competent students and the achievement of skill scores also increased in terms of learning completeness, namely to 94 % of students are competent.
Relevansi Mata Kuliah Ilmu Bahan Bangunan terhadap Bahan Bangunan di Dunia Industri
Authors: Ayunda Anestasya , Sambowo Kusno Adi
Published: September 2020

In the current era of the development of the infrastructure industry, the building material industry in Indonesia has developed very rapidly along with the increasing national economic conditions and innovative technological advancements. Given the demands and encouragement from the industrial world, the Building Material Science Course is expected to be a means to shape these competencies by looking at the relevance of the development of innovative building materials, so that graduates are expected to produce students who have up-to-date knowledge and competencies related to materials building in the industrial world. The purpose of this article is to increase knowledge and information related to the development of building materials, especially buildings in the industrial world, through the study of Building Materials Science. The method used is the literature review. Literature study results show that learning from lectures is able to contribute to the increase in knowledge and competencies related to the development of building materials that are relevant to the industrial world, one of which is the Building Materials Science Course. The more competence of students regarding building materials, the building in any form can be easily realized when working in the industrial world.
Faktor-faktor yang Mempengaruhi Kunjungan Pasien Terhadap Standar Pelayanan di Apotek Kimia Farma 278 Versailles dengan Menggunakan Analisis Faktor
Authors: Madi Il , Ningsi Besse Arnawisuda
Published: September 2020

To guarantee pharmaceutical service standards (Apotek), factors that need to be considered are the quality of human resources, complete facilities and infrastructure, prescription services (including drug information), counseling, monitoring drug use, health education and promotion, and evaluation of treatment. This is very important because it will have a positive impact and is very profitable, if the standard is met. Kimia Farma 278 Versailles pharmacies need to improve quality, especially in terms of service. Factor analysis methods can be used to see what factors influence patient visits to service standards. This type of research is descriptive research. Based on the results of the analysis there are 5 factors that are formed from the process of reducing delivery and Go-Mart services that can help patients. It is important to attract interest in coming to the pharmacy. Offered discounts, medicines submitted with standardized health education, offering drug packaging is more economical, the drug offered as a substitute does not have a negative impact, the ability of the knowledge officer to offer substitute drugs in accordance with the Service Standards at the pharmacy, Treatment is more maximal with the presence of checks from the officer (F1). Prices are commensurate with the drugs that are expected, quality drugs, pharmacies have a good reputation (F2). Clean, neat and comfortable, the price is commensurate with the drug you expect (F3). Having decent and adequate building facilities and interior, building exterios look good (F4), and the suitability of the product you want (F5)
Pengklasifikasian Pengguna Internet Lingkungan Pedesaan Menurut Jenjang Pendidikan di Indonesia menggunakan Metode Cluster Average Linkage
Authors: Simamora Hemelia , Bagus Sumargo
Published: September 2020

Pengguna internet semakin meningkat setiap tahunnya, oleh karena itu dilakukan analisis clus-ter dalam pengklasi kasian pengguna internet setiap provinsi. Hal tersebut dilakukan untuk mengetahui karakteristik setiap kelompok yang terbentuk. Pada jurnal ini, metode cluster yang digunakan adalah metode Average Linkage. Tujuan dari jurnal ini adalah untuk mengetahui proses penglusteran dengan metode Average Linkage dan mengetahui hasil cluster yang terbentuk dengan menggunakan metode tersebut. Dalam metode ini, data pengguna internet daerah pedesaan menurut jenjang pendidikan di Indonesia dihitung kemiripannya untuk dilakukan pengelompokkan. Kemiripan tersebut dihitung meng-gunakan jarak Euclidean, kemudian terbentuk cluster, dan dilakukan perhitungan simpangan baku antar kelompok dan simpangan baku dalam kelompok untuk mengetahui metode cluster yang memiliki kinerja yang baik.
Metode Naive Bayes dalam Mendeteksi Sel Kanker Payudara
Authors: Riska Agustin  , Vera Maya Santi  , Bagus Sumargo
Published: September 2020

Kanker payudara merupakan kanker paling umum dan paling banyak terjadi pada wanita di seluruh dunia. Di Indonesia sendiri kasus kanker payudara menempati posisi pertama kanker yang paling banyak menyebabkan kematian pada wanita. Tingginya angka kematian karena kanker payudara di Indonesia perlu dicermati dengan tindakan pencegahan dan deteksi dini. Kasus kanker yang ditemukan pada stadium dini serta mendapat pengobatan yang cepat dan tepat akan memberikan kesembuhan dan harapan hidup lebih lama. Ada beberapa faktor yang dapat digunakan untuk memprediksi keberadaan kanker payudara pada tubuh seseorang, diantaranya adalah usia, glukosa, insulin, HOMA (Homeostatic Model Assessment), leptin, adiponektin, resistin, MCP-1 (Monocyte Chemoattractant Protein-1), serta IMT (Indeks Massa Tubuh). Pada penelitian ini akan dibahas mengenai kemungkinan seseorang menderita kanker payudara berdasarkan faktor-faktor pendorong yang diamati menggunakan metode Naive Bayes. Hasil akurasi yang diperoleh adalah sebesar 80% dimana dari 35 data uji yang diamati terdapat 28 data yang di klasifikasikan dengan tepat dan 7 data yang mengalami kesalahan klasifikasi.
Peramalan Nilai Ekspor Produk Industri Alas Kaki Menggnakan Model ARIMAX dengan Efek Variasi Kalender
Authors: Kurnia Alma , Ibnu Hadi
Published: September 2020

Model ARIMAX adalah model ARIMA dengan peubah tambahan. Peubah tambahan yang digunakan untuk data deret waktu dengan variasi kalender berupa variabel dummy. Pada makalah ini, akan dilakukan penghitungan peramalan nilai ekspor produk industri alas kaki bulan Juli 2019 sampai dengan Jui 2020 dengan menggunakan model ARIMAX dengan efek variasi kalender. Efek variasi kalender yang ditemukan pada data nilai ekspor produk industri alas kaki adalah libur hari raya Idul Fitri. Data yang digunakan pada makalah ini yaitu data nilai ekspor produk industri alas kaki mulai dari bulan Januari tahun 2010 sampai dengan bulan Juni tahun 2019. Pemodelan ARIMAX dilakukan dengan menggabungkan model regresi dummy dari data aktual dan model ARIMA dari data residual.
Monitoring Hospital Performance with Statistical Process Control After Total Hip and Knee Arthroplasty
Authors: van Schie Peter , van Bodegom-Vos Leti , van Steenbergen Liza N. , Nelissen Rob G.H.H. , Marang-van de Mheen Perla J.
Published: September 2020

Background:

Given the low early revision rate after total hip arthroplasty (THA) and total knee arthroplasty (TKA), hospital performance is typically compared using 3 years of data. The purpose of this study was to assess how much earlier worsening hospital performance in 1-year revision rates after THA and TKA can be detected.

Methods:

All 86,468 THA and 73,077 TKA procedures performed from 2014 to 2016 and recorded in the Dutch Arthroplasty Register were included. Negative outlier hospitals were identified by significantly higher O/E (observed divided by expected) 1-year revision rates in a funnel plot. Monthly Shewhart p-charts (with 2 and 3-sigma control limits) and cumulative sum (CUSUM) charts (with 3.5 and 5 control limits) were constructed to detect a doubling of revisions (odds ratio of 2), generating a signal when the control limit was reached. The median number of months until generation of a first signal for negative outliers and the number of false signals for non-negative outliers were calculated. Sensitivity, specificity, and accuracy were calculated for all charts and control limit settings using outlier status in the funnel plot as the gold standard.

Results:

The funnel plot showed that 13 of 97 hospitals had significantly higher O/E 1-year revision rates and were negative outliers for THA and 7 of 98 hospitals had significantly higher O/E 1-year revision rates and were negative outliers for TKA. The Shewhart p-chart with the 3-sigma control limit generated 68 signals (34 false-positive) for THA and 85 signals (63 false-positive) for TKA. The sensitivity for THA and TKA was 92% and 100%, respectively; the specificity was 69% and 51%, respectively; and the accuracy was 72% and 54%, respectively. The CUSUM chart with a 5 control limit generated 18 signals (1 false-positive) for THA and 7 (1 false-positive) for TKA. The sensitivity was 85% and 71% for THA and TKA, respectively; the specificity was 99% for both; and the accuracy was 97% for both. The Shewhart p-chart with a 3-sigma control limit generated the first signal for negative outliers after a median of 10 months (interquartile range [IQR] = 2 to 18) for THA and 13 months (IQR = 5 to 18) for TKA. The CUSUM chart with a 5 control limit generated the first signal after a median of 18 months (IQR = 7 to 22) for THA and 21 months (IQR = 9 to 25) for TKA.

Conclusions:

Monthly monitoring using CUSUM charts with a 5 control limit enables earlier detection of worsening 1-year revision rates with accuracy so that initiatives to improve care can start earlier.
How Canada’s Black Hockey League Shaped the Sport and the Path to Our Arrival in the NHL Today
Authors: Boyd Joel L.
Published: September 2020

Willie O’Ree, known as the “Jackie Robinson of hockey,” was the first Black player in the National Hockey League (NHL), debuting with the Boston Bruins in 1958. From the moment the Canadian-born player stepped onto the ice, he changed the notion of hockey as a “White sport,” and he has dedicated his career to making it more accessible, including working with the NHL Diversity Task Force initiative Hockey Is For Everyone (HIFE). HIFE supports nonprofit hockey programs around the country and gives kids from all backgrounds the opportunity to try out their skills on the ice. Since 1994, Willie O’Ree has introduced 50,000 children across North America to the sport. Nonetheless, in the NHL today, only approximately 5% of the players (43 of >700) are players of color. However, several aspects of hockey’s history, and innovations in the game, can be traced back to communities of color. Established in 1895, the Black Hockey League (BHL) of the Maritimes in Canada grew out of local churches in small towns such as Africville, Nova Scotia. By the beginning of the 20th century, the BHL had grown from a 3-team league to include newly formed teams across the region. The league had its own championship at a time when Black players were not allowed to play for the Stanley Cup. The BHL was at its height between 1890 and 1930, with hundreds of players, 12 teams, and as many as 1,200 spectators. Unfortunately, the Canadian government did not provide equitable resources, and churches alone could not maintain these small Black communities. As the NHL developed, focus shifted away from regional leagues. In 2018, Willie O’Ree was inducted into the NHL Hall of Fame. Although he may have broken the color barrier in 1958, hockey is still a predominantly White sport, and society continues to grapple with systematic racism. NHL players have formed an independent group, the Hockey Diversity Alliance, to work to make the game more socioeconomically inclusive and to help eradicate racism and intolerance.
Pertanggungjawaban Pidana US Terkait Kegiatan Pengelolaan Lahan Di Kawasan Hutan Secara Tidak Sah Ditinjau Dari Undang-Undang Nomor 41 Tahun 1999 Tentang Kehutanan
Authors: Haryanto Cindy Angelin
Published: September 2020

Lingkungan hidup adalah segala sesuatu yang ada disekitar kehidupan manusia yang keberadaannya secara langsung dan tidak langsung sangat berpengaruh terhadap keberlangsungan hidup manusia serta makhluk hidup lainnya. Lingkungan hidup merupakan bagian yang mutlak dari kehidupan manusia. Mengenai lingkungan hidup telah diatur dalam Undang-Undang Dasar Negara Republik Indonesia Tahun 1945 (selanjutnya disebut UUD 1945) Pasal 28H ayat (1), yaitu menentukan bahwa setiap orang berhak hidup sejahtera lahir dan batin, bertempat tinggal dan mendapatkan lingkungan hidup yang baik dan sehat serta berhak memperoleh pelayanan kesehatan. Lingkungan hidup yang baik dan sehat merupakan hak yang harus didapat oleh semua warga negara Indonesia karena telah diatur dalam UUD 1945. Indonesia merupakan salah satu negara dengan keanekaragaman hayati tertinggi di dunia, yang mana semuanya berada di dalam Hutan Tropis Indonesia. Dengan besarnya hutan di Indonesia dan sumber daya alam lainnya, banyak orang yang mengelola atau menggunakan lahan perhutanan secara illegal atau tanpa izin. Kerusakan bagi lingkungan akan memberikan kerugian yang sangat besar bagi kehidupan masyarakat di Indonesia.
INNOCENT UNTIL PRESENTED
Authors: Pangaribuan Aristo
Published: September 2020

This paper analyzes a practice of presenting suspects, which is a ritual that displays a suspect before the media. Until now, although it is frequently used by the police, there has been no attempt to examine such practices in Indonesia. In the criminal procedure scholarship, there is no standard term to describe it. This article will refer to such ritual as a presentation of suspects. This ritual has also been practiced around the world with different methods and has a long history, especially in the United States. This article discusses the presentation of suspects and question whether such a ritual is a violation of the fundamental rights of being presumed innocent until found guilty. Two issues will be examined to answer this question: The purported objectives for the practice and the accused’s right to be presumed innocent. The term innocence here is a presumptively innocent and not factually innocent. With that in mind, to some degree, this article realizes it would be permissible to deprive their liberty if it has a higher purpose.
Prognostic factors and survival according to tumour subtype in women presenting with breast cancer bone metastases at initial diagnosis: a SEER-based study
Authors: Li Xiao , Zhang Xiaoli , Zhong Shen Yin , Liu Jie
Published: September 2020

Background: Tumour subtype has a significant effect on bone metastasis in breast cancer, but population-based estimates of the prognosis of patients with bone metastases at breast cancer diagnosis are lacking. The aim of this study was to analyse the influence of tumour subtype and other factors on the prognosis and survival of patients with bone metastases of breast cancer.Methods: Using the Surveillance, Epidemiology, and End Results (SEER) Program data from 2012 to 2016, a retrospective cohort study was conducted to investigate stage IV breast cancer patients with bone metastases. Stage IV patient characteristics according to subtype were compared using chi-square tests. Overall survival (OS) and prognostic factors were compared using the Kaplan-Meier method and the Cox proportional hazards model, respectively.Results: A total of 3384 stage IV patients were included in this study; 63.42% were HR+/HER2-, 19.86% were HR+/HER2+, 9.34% were HR-/HER2-, and 7.39% were HR-/HER2+. The median OS for the whole population was 38 months, and 33.9% of the patients were alive at five years. The median OS and five-year survival rate were significantly different among stage IV breast cancer patients with different molecular subtypes (p<0.05). Multivariate Cox regression analysis showed that age of 55-59 (HR=1.270), black race (HR=1.317), grade III or IV (HR=1.960), HR-/HER2- (HR=2.808), lung metastases (HR=1.378), liver metastases (HR=2.085), and brain metastases (HR=1.903) were independent risk factors for prognosis; married status (HR=0.819), HR+/HER2+ (HR=0.631), HR-/HER2+ (HR=0.716), insurance (HR=0.587) and surgery (HR=0.504) were independent protection factors of prognosis. There was an interaction between the HR+/HER2+ subtype and other metastases (except bone metastases, HR=0.694, 95% CI: 0.485-0.992), but the interaction between race and subtype did not reach significance for prognosis.Conclusions: There were substantial differences in OS according to tumour subtype. In addition to tumour subtype, other independent predictors of OS were age at diagnosis, race, marital status, insurance, grade, surgery and visceral metastases. There was an interaction between the HR+/HER2+ subtype and other metastases (except bone metastases) for prognosis. Tumour subtype, as a significant prognostic factor, warrants further investigation.
Isolation and Characterization of Uropathogenic Escherichia coli (UPEC) from Red Panda (Ailurus fulgens)
Authors: Liu Songrui , Li Yunli , Yue Chanjuan , Zhang Dongsheng , Su Xiaoyan , Yan Xia , Yang Kuixing , Chen Xin , Zhuo Guifu , Cai Tong , Liu Jiangfeng , Peng Xi , Hou Rong
Published: September 2020

Background Disease prevention and control is a significant part in the ex-situ conservation of the endangered red panda (Ailurus fulgens), being bacterial infection is one of the most important health threats to the captive population. To date, studies about the infection caused by Escherichia coli in the red panda are scarce. This study was conducted to determine the cause of death of a captive red panda through clinical symptoms, complete blood count, biochemical analysis, pathological diagnosis and bacterial whole genome sequencing.Case presentation The following report describes a case of a 1.5 year old captive red panda (Ailurus fulgens) that was found lethargic and anoretic. She was moved to the quarantine area for daily treatment with 50mg of cefpodoxime proxetil. During the three-day treatment, she did not eat or defecate, and then died. Clinical hematology revealed the values of neutrophils; alanine aminotransferase (ALT), aspartate aminotransferase (AST) and blood urea nitrogen (BUN) were significantly higher. Histological analysis demonstrated major pathological damage in the kidneys, liver and lungs, characterized by hyperemia, parenchymal cell degeneration and necrosis and inflammatory cell infiltration which were predominantly neutrophilic. A bacterial strain confirmed as Escherichia coli was isolated post mortem. Whole genome sequencing of the E. coli showed the complete genome size was 4.99 Mbp. PapA, PapG, OmpA, OmpU and other virulence factors which specific to Uropathogenic Escherichia coli (UPEC) were found in the isolate. Among the virulence factors, P pili, type I pili and related factors of the iron uptake system were associated with nephrotoxicity. Conclusion The red panda died of bacterial infection caused by an uropathogenic strain of Escherichia coli. The pathogenic mechanisms of the strain are closely related to the expression of specific virulence genes.
Preparation of biological samples for the recording of electrophysiological signals using high-density microelectrode arrays
Authors: Yuan Xinyue , Schröter Manuel , Obien Marie Engelene J. , Fiscella Michele , Gong Wei , Kikuchi Tetsuhiro , Odawara Aoi , Noji Shuhei , Suzuki Ikuro , Takahashi Jun , Hierlemann Andreas , Frey Urs
Published: September 2020

The use of high-density microelectrode arrays (HD-MEAs) provides a promising approach for electrophysiological studies targeted at understanding of brain functions, profiling of neurodegenerative diseases, and drug screening. Here we present the protocol for the preparation of various biological samples for the recording of extracellular signals using HD-MEA, including primary cortical neurons, induced pluripotent stem cells (iPSCs)-derived neurons, rodent brain slices, retina, and iPSC-derived neuronal spheroids.
Development and external validation of a nomogram for predicting the effect of tumor size on survival of patients with perihilar cholangiocarcinoma
Authors: Zhang Yaodong , Wu Zhengshan , Wang Xing , Li Changxian , Chang Jiang , Jiang Wangjie , Wang Hongwei , Wang Yirui , Li Xiangcheng
Published: September 2020

Background: The effect of tumor size on account of the long-term survival results in perihilar cholangiocarcinoma (PCCA) patients has remained a controversial debate. It is urgent necessary to identify the optimal cutoff value of tumor size in PCCA and integrate tumor size with other prognostic factors into a nomogram to improve the predictive accuracy of the prognosis of patients with PCCA. Methods: 363 PCCA patients underwent surgical resection were extracted from the Surveillance, Epidemiology and End Results (SEER) database. X-tile program was used to identify the optimal cutoff value of tumor size. A nomogram including tumor size was established to predict 1-, 3- and 5-year cancer-specific survival (CSS) based on the independent risk factors chosen by Kaplan-Meier methods and multivariable cox regression models. The precision of the nomogram for predicting survival was validated internally and externally. Results: PCCA patients underwent surgical resection were classified into 1-19 mm, 20-33 mm and ³34 mm subgroup based on the optimal cutoff for tumor size in terms of CSS. And we noticed that more larger tumor size group had worse tumor grade, advanced T stage, more positive regional lymph nodes and more frequency vascular invasion. The nomogram according to the independent factors was well calibrated and displayed better discrimination power than 7 th Tumor-Node-Metastasis (TNM) stage systems. Conclusions: The results demonstrated that the larger the tumor size was, the worse the survival would be. The proposed nomogram, which outperforms the conventional TNM staging system, showed consistently reliability and clinically practicality for predicting the prognosis of PCCA patients.
Bortezomib administration is a risk factor associated with the development of tumor lysis syndrome in male patients with multiple myeloma: A retrospective study
Authors: Kondo Masahiro , Hotta Yuji , Yamauchi Karen , Sanagawa Akimasa , Komatsu Hirokazu , Iida Shinsuke , Kimura Kazunori
Published: September 2020

Background: Novel agents such as proteasome inhibitors have been developed for several years to treat multiple myeloma. Although multiple myeloma is a low-risk disease for developing tumor lysis syndrome (TLS), treatment with these novel therapies might increase TLS risk. Previous studies, mostly case reports or case series, have reported bortezomib-induced TLS in patients with multiple myeloma. This study aimed to investigate risk factors associated with TLS development in multiple myeloma patients.Methods: We retrospectively investigated incidences of laboratory and clinical TLS (LTLS and CTLS, respectively) in patients who received primary therapy for treatment-naive, symptomatic multiple myeloma between May 2007 and January 2018. We used multivariate logistic regression analyses to evaluate the associations between TLS and several parameters previously reported to be associated with increased risk.Results: This study included 210 patients with multiple myeloma, of which ten (4.8%) had LTLS and seven (3.3%) had CTLS. The characteristics of the administered anticancer or prophylactic antihyperuricemic agents were similar between patients with and without TLS. Multivariate analyses revealed that TLS was most strongly associated with bortezomib-containing therapy (odds ratio = 3.40, P = 0.069), followed by male sex (odds ratio = 2.29, P = 0.153). In a subgroup analysis focused on men, treatment with bortezomib-containing therapy was significantly associated with increased risk of TLS (odds ratio = 8.51, P = 0.046).Conclusion: In the present study, we investigated the risk factors associated with TLS development in 210 multiple myeloma patients, which, to the best of our knowledge, is the largest number of patients reported to date. Furthermore, this study is the first to evaluate TLS risk factors in MM by adjusting for the effects of potential confounding factors in patients’ backgrounds. Consequently, we found that bortezomib-containing therapy increases the risk of TLS in male patients with multiple myeloma. TLS risk should be evaluated further in low-risk diseases such as multiple myeloma, since a significant number of novel therapies can achieve high antitumor responses.
Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with Attention-Deficit/Hyperactivity Disorder
Authors: Saito Takuya , Yamashita Yushiro , Tomoda Akemi , Okada Takashi , Umeuchi Hideo , Iwamori Saki , Shinoda Satoru , Mizuno-Yasuhira Akiko , Urano Hidetoshi , Nishino Izumi , Saito Kazuhiko
Published: September 2020

Background Asverin® (tipepidine hibenzate) has been used as an antitussive for >50 years in Japan. Studies revealed that tipepidine modulates monoamine levels, by inhibiting G-protein-activated inwardly rectifying potassium (GIRK) channels, expecting the potential therapeutic effects of tipepidine for attention-deficit/hyperactivity disorder (ADHD) in recent years. In this study, TS-141, a sustained-release tablet of tipepidine, was developed for the treatment of ADHD through a drug repositioning approach. Methods The sustained-release profile of TS-141 in healthy adults was investigated, and tipepidine exposure in the plasma after the TS-141 administration was compared to that of Asverin in the phase I study. Phase II study was conducted to examine the effects of TS-141 30 (once a day), 60 (once a day), 120 mg (60 mg twice a day), or placebo, that is within the exposure in the maximum dosage of Asverin, in children and adolescents with ADHD, and was designed as an 8-week treatment, randomized, parallel group, double-blind, placebo-controlled trial recruiting 6–17-year-old children and adolescents diagnosed with ADHD. A total of 216 patients were randomized according to the CYP2D6 phenotype. The primary end-point was ADHD Rating Scale IV-J changes. Furthermore, effects of CYP2D6 phenotype on the efficacy in the subgroup analysis were investigated. Results TS-141 had the sustained-release profile, and the CYP2D6 phenotype had effects on the plasma exposure of tipepidine. ADHD RS-IV-J scores in all TS-141 dosages decreased from their baseline scores; however, no significant difference was observed in ADHD RS-IV-J score changes between the placebo and TS-141-administered groups. In patients with intermediate metabolizer CYP2D6, ADHD RS-IV-J score changes in the 120 mg group tended to be larger than that in the placebo group. Conclusions ADHD RS-IV-J changes on TS-141 may depend on the interaction between the TS-141 dose and CYP2D6 phenotype, suggesting that further clinical trials should be conducted with careful consideration of polymorphism. Drug repositioning approach of TS-141 was attempted at the same dose as that of antitussive; however, dose setting according to the indication was necessary. Trial Registration Phase I study: JapicCTI-205235 (Registered 25 March 2020), Phase II study: JapicCTI-163244 (Registered 9 May 2016), https://www.clinicaltrials.jp/cti-user/trial/Show.jsp
Distinct Effect of Body Mass Index by Sex as a Prognostic Factor in Localized Renal Cell Carcinoma Treated with Nephrectomy ~ Data from a Multi-Institutional Study in Japan ~
Authors: Tsutsumi Takeshi , Komura Kazumasa , Hashimoto Takeshi , Muraoka Ryu , Satake Naoya , Matsunaga Tomohisa , Tsujino Takuya , Yoshikawa Yuki , Takai Tomoaki , Minami Koichiro , Taniguchi Kohei , Tanaka Tomohito , Uehara Hirofumi , Hirano Hajime , Nomi Hayahito , Ibuki Naokazu , Takahara Kiyoshi , Inamoto Teruo , Ohno Yoshio , Azuma Haruhito
Published: September 2020

Background: We assessed the prognostic value of body mass index (BMI) in Asian patients with localized RCC who underwent nephrectomy.Methods: A total of 665 patients who underwent nephrectomy for localized RCC were enrolled in the present study and divided into the two BMI groups: i.e., BMI <25 in 463 (69.6%) and BMI >25 in 202 (30.4%) patients.Results: In total, there were 482 (72.5%) males and 183 (27.5%) females. Five-year cancer-specific survival (CSS) rates were significantly higher in increased BMI compared to lower BMI group (97.1 and 92.5%: P = 0.007). When stratified by sex, significantly longer CSS in higher BMI was confirmed in male (5-year CSS of 92.7% in BMI <25 and 98.1% in BMI >25, p=0.005), while there was no difference in CSS between BMI groups for female patients. Multivariate analysis exhibited that higher BMI was an independent predictor for favorable CSS in male (cox model: p=0.041, Fine & Gray regression model: p=0.014), but not in the female. Subgroup analysis for CSS revealed that favorable CSS with higher BMI was observed in patient subgroups of age <65 (p=0.019), clear cell histology (p=0.018), and tumor size >4cm, p=0.020) as well as male (p=0.020).Conclusion: Our findings collected from the multi-institutional Japanese dataset demonstrated the longer survival in patients with higher BMI than lower BMI for non-metastatic RCC treated with nephrectomy. Intriguingly, this finding was restricted to males, but not to females.
Effectiveness of The Back School and The Pilates Method in Disability and Pain of Patients With Chronic Non-Specific Low Back Pain. Randomized Controlled Clinical Trial.
Authors: Mesa Mario Manuel López , Fernandez Javier Julian Cabrerizo , Roman Antonio Lopez , Fernandez Eva Maria Rodriguez
Published: September 2020

Objective: The purpose was to compare the effectiveness of the Pilates Method versus the Back School in specialized care, assessing improving the disability with the Roland Morris questionnaire and the perceived pain with the visual analog scale (VAS) in people with non-specific chronic low back pain. Method: Single-blind randomized controlled trial to determine the effects of the Pilates Method for patients with low back pain compared to Back School exercises, two groups of 48 patients, 3-month treatment period. Results: The Pilates Group (GP) recorded significant improvements in all of the variables that were the subject for this research, compared to those provided by the Back School Group (GEE). In the Roland Morris questionnaire of 0,41 points [GP (Mean difference [MD] Pretreatment-posttreatment =2,08; 95% confidence interval [CI] = 1,21 to 2,95; p=0,001) vs GEE ( MD=1,66; 95% confidence interval [CI] = 0,90 to 2,43; p=0,001 )]. In the visual analog scale (VAS) of 0,40 points [ GP (Mean difference [MD] Pretreatment-posttreatment =1,82; 95% confidence interval [CI] = 1,24 to 2,40; p=0,001 ) vs GEE (MD=1,42; 95% confidence interval [CI] = 0,82 to 2,04; p=0,001)]. Conclusions: The treatment of nonspecific low back pain with therapeutic Pilates is more effective than the therapeutic treatment of the Back School, both in terms of functional disability and intensity of pain. Trial registration : This trial is registered in http://www.ensaiosclinicos.gov.br/rg/RBR-5nk2tr/ , with the ID number of RBR-5nk2tr
Suicide Reduction in Schizophrenia via Exercise (SUnRISE): Study Protocol for A Multi-Site, Single-Blind, Randomized Clinical Trial of Aerobic Exercise for Suicide Risk Reduction in Individuals With Schizophrenia
Authors: Beck-Felts Katie , Goodman Marianne , Ospina Luz , Wall Melanie , Evoy Joseph Mc , Jarskog Lars , Ballon Jacob , Bartels Matthew , Buchsbaum Richard , Sloan Richard P , Stroup Scott T. , Kimhy David
Published: September 2020

Background: Suicide risk among individuals with schizophrenia (SZ) is intractably high, with over 40% of individuals attempting to take their own lives during their lifetime and an estimated 5-10% completing suicide. At present, available pharmacological and psychotherapeutic treatments offer limited risk reduction benefits, thus there remain an urgent need to explore novel interventions that will ameliorate this risk. Aerobic exercise (AE) has been shown to improve a number of predictors of suicide risk (e.g., depressed mood, sleeping difficulties). As individuals with SZ display a highly sedentary lifestyle, AE may reduce suicide risk. Methods: Employing a multi-site, single-blind, randomized clinical trial design, we will examine the impact of AE on risk for suicide and related variables in individuals with SZ. Participants will be randomized to one of two 12-week exercise interventions: AE or a stretching and toning (ST) control intervention. Primary outcome measures will include suicide risk (Columbia Suicide Severity Rating Scale, C-SSRS) and aerobic fitness (VO2max), along with additional measures of suicide risk, mood, emotion regulation, sleep, cognition, and physical activity, with assessments completed at baseline and after 6- and 12-weeks of interventions.Discussion: It is hypothesized that AE will reduce suicide risk among individuals with SZ. This study may offer support for a more efficacious treatment method for this population in addition to the pre-existing pharmacological and psychotherapeutic treatment regimens. Trial Registration: Clinicaltrials.gov, NCT03270098. Registered September 1, 2017.
The study of neuroprotective effects and underlying mechanism of Naoshuantong capsule on ischemia stroke mice
Authors: Luo Lvkeng , Wu Shuling , Chen Ruiqi , Rao Hongyu , Peng Wei , Su Weiwei
Published: September 2020

Background: Naoshuantong capsule (NSTC) is an oral Chinese medicine formula composed of Typhae Pollen, Radix Paeoniae Rubra Curcumae Radix Gastrodiae Rhizoma and Radix Rhapontici. It has been widely used at the acute and recovery stage of ischemic stroke since 2001. Comparing with its wide clinical application, there are only few studies emphasize on investigating its pharmacological effects. Methods:To more generally elucidate the underlying mechanisms in this study, we identified active ingredients in NSTC by a network pharmacology approach based on transcriptomics analysis and pharmacological experiments. Modified neurological severity scores and morphometric analysis using Nissl staining were employed to evaluate the neuroprotective effects of NSTC on ischemia stroke in mice. Results: The results showed that NSTC had preventive and protective effects on ischemia stroke, featuring repair of brain tissue during the sub-acute stage of stroke. This may attribute to the underlying mechanisms including anti-inflammatory, antioxidant, and anti-apoptotic activities, as well as an attenuation of excitatory amino acids (EAAs) toxicity of the active ingredients, especially the most active apigenin, from NSTC. Specifically, naringenin, calycosin, gastrodin, caffeic acid, paeoniflorin, and β -elemene seem to be also pharmacological active substances responsible for the anti-inflammatory effects. Meanwhile, 13-hydroxygemone, gastrodin, and p-hydroxybenzyl alcohol contributed to the attenuation of EAAs toxicity Furthermore, apigenin, naringenin, calycosin, gastrodin, and β-elemene accelerated the repair of brain ischemic tissue by up-regulating the expression of TGF-β1 levels.Conclusions: The present study identifies the active ingredients of NSTC and illustrates the underlying mechanism using a combination of network pharmacology, transcriptomics analysis, and pharmacological experiments.
Preoperative circulating tumor cells to predict microvascular invasion and dynamical detection indicate the prognosis of hepatocellular carcinoma
Authors: Zhou Jiangmin , Zhang Zhiwei , Zhou Honghao , Leng Chao , Hou Bingwu , Zhou Chenyang , Hu Xinsheng , Wang Jinlin , Chen Xiaoping
Published: September 2020

Background: This study explored the diagnostic power of preoperative circulating tumor cells (CTCs) for the presence of microvascular invasion (MVI) and the relationship between dynamic changes in postoperative CTCs and prognosis. Methods: A total of 137 patients were recruited for the study. Preoperative blood samples of all patients were collected to detect CTC. The time points for blood collection were before the operation, during operation, and at one week, one month, two months, three months, six months, and one year after surgery. The power of predicting the presence of MVI was analyzed by the receiver operating characteristic curve (ROC). According to the survival status, 137 patients were divided into three groups: no recurrence, early recurrence, and non-early recurrence. Results: A threshold CTC value of 5 showed the most significant power to predict the existence of MVI. In a multivariate analysis, the parameters of preoperative CTCs, alpha-fetoprotein (AFP) and tumor diameter were independent predictors of MVI ( P < 0.05). A CTC value greater than or equal to 5 has better predictive value than AFP > 400μg/L or tumor diameter > 5 cm. The number of intraoperative CTCs in the three groups did not increase compared to before surgery ( P > 0.05). The number of CTC in the non-recurrent group and the non-early recurrent group decreased significantly one week after surgery compared with intraoperative values ( P < 0.001), although there was no statistical significance in the group with early recurrence ( P = 0.95). Patients with mean CTC ≥ 5 had significantly worse long-term outcome than those with mean CTC < 5 ( P <0.001).Conclusion: The preoperative CTC counts in peripheral blood of patients with HCC is closely correlated to MVI. Intraoperative manipulation for the lesion by the surgeon does not increase the number of CTC in peripheral blood. Surgical removal of the tumor decreases the number of CTC. The persistence of CTC at a high level (≥ 5) after surgery suggests a risk of early recurrence.
Reactive Attachment Disorder Symptoms and Prosocial Behavior in Middle Childhood: The Role of Secure Base Script Knowledge 
Authors: Cuyvers Bien , Vervoort Eleonore , Bosmans Guy
Published: September 2020

Background: Children with attachment disorder show prosocial behavior problems. Children with a reactive attachment disorder show inhibited and emotionally withdrawn behavior. Consequently, these children typically display prosocial behavior problems. However, the underlying mechanism between reactive attachment disorder and prosocial behavior problems is still unclear and findings in literature are mixed. Methods: The current study investigated the role of children’s attachment representations in this association. Attachment representations reflect knowledge about a cognitive script regarding the attachment figure as a source for support (Secure Base Script). We tested whether secure base script knowledge 1) mediates or 2) moderates the link between reactive attachment disorder and prosocial behavior problems in 83 children (6-11 years; 83.1% boys) recruited from special education schools for children with behavioral problems. Children completed a pictorial Secure Base Script Test. Their reactive attachment disorder symptoms were assessed during an interview with the primary caregivers. Primary caregivers and teachers filled out a prosocial behavior questionnaire about the child. Results: Results did not support the mediation hypothesis, but evidence for the moderation hypothesis was found. Secure base script knowledge attenuated the negative association between attachment disorder symptoms and prosocial behavior. Conclusions: These findings contribute to the discussion about the link between attachment representations and attachment disorders.
WRN modulates translation by influencing nuclear mRNA export in HeLa cancer cells
Authors: Iglesias-Pedraz Juan Manuel , Jara Diego Matia Fossatti , Felice Valeria Del Carmen Valle-Riestra , Visalaya Sergio Rafael Cruz , Felix Jose Antonio Ayala , Comai Lucio
Published: September 2020

Background The Werner syndrome protein (WRN) belongs to the RecQ family of helicases and its loss of function results in the premature aging disease Werner syndrome (WS). We previously demonstrated that an early cellular change induced by WRN depletion is a posttranscriptional decrease in the levels of enzymes involved in metabolic pathways that control macromolecular synthesis and protect from oxidative stress. This metabolic shift is tolerated by normal cells but causes mitochondria dysfunction and acute oxidative stress in rapidly growing cancer cells, thereby suppressing their proliferation.Results To identify the mechanism underlying this metabolic shift, we examined global protein synthesis and mRNA nucleocytoplasmic distribution after WRN knockdown. We determined that WRN depletion in HeLa cells attenuates global protein synthesis without affecting the level of key components of the mRNA export machinery. We further observed that WRN depletion affects the nuclear export of mRNAs and demonstrated that WRN interacts with mRNA and the Nuclear RNA Export Factor 1 (NXF1).Conclusions Our findings suggest that WRN influences the export of mRNAs from the nucleus through its interaction with the NXF1 export receptor thereby affecting cellular proteostasis. In summary, we identified a new partner and a novel function of WRN, which is especially important for the proliferation of cancer cells.
The influence of gingival phenotype on the morphology of the maxillary central papilla
Authors: Belák Šimon , Žižka Radovan , Starosta Martin , Zapletalová Jana , Šedý Jiří , Štefanatný Michal
Published: September 2020

Background Preservation of the interdental papilla is an essential part of the functional and esthetic rehabilitation of dental treatment. It has been described that thicker gingival tissues are more resistant to recession. The main objective of this investigation was to analyze whether a thin gingival phenotype represents a potential risk factor affecting interdental papilla fill, height, or width in an esthetic region between maxillary central incisors. The secondary goals were: 1) to analyze parameters describing the papilla – fill, height, width, and effect of papilla base width on the vertical papillary dimension; 2) to determine correlation between different non-invasive measurements of gingival thickness; 3) to compare both sexes.Methods A total of 54 periodontally healthy students (20–30 years old) were included in the study. Gingival thickness was measured using Pirop Ultrasonic Biometer. Gingival phenotype was also assessed by gingival probe transparency. Papilla height and width were measured, and the degree of papilla recession was classified.Results No significant correlation between papilla fill, height, width and gingival probe transparency or gingival thickness was found. Gingival thickness and gingival probe transparency showed a significant relationship (P < 0.001). There was a significant correlation between papilla height and papilla fill (P = 0.028). A papilla which filled the interdental space completely seemed to be shorter. A strong positive association between papilla height and papilla width was found (P <0.0001). The papilla between maxillary central incisors was significantly higher in males (P = 0.01).Conclusion The appearance of the interdental papilla may be influenced by various factors. Within the limitations of this study, the results showed that the thin gingival phenotype alone is no potential risk factor affecting interdental papilla fill, height, or width. There seems to be an effect of papilla base width on its vertical dimension. Gingival probe transparency is a simple reliable method of assessment of gingival thickness with a threshold value of 1-mm gingival thickness between the thick and thin phenotypes.