bluuebunny/crossref_metadata_2025 huggingface dataset:
Built to Destroy
Authors: Manley Sarah
Published: February 2024

David Cronenberg’s cult classic horror film
The Brood
explores the breakdown of the nuclear family as the impotent Father fails to protect the Child from the destructive threat of the Mother. The article argues that the film employs a misogynistic, eugenic gaze which compels viewers to perceive the “antagonist” Nola as a violent madwoman whose actions necessitate her destruction by the forces of professional male rationality. In constructing such a woman, the film’s eugenic gaze encourages co-identification with a cast of professional men who set out to destroy the very monster their misapprehension has helped to create. Building on scholarship in feminist film theory and disability studies, the article elaborates the many eugenic gazes operant in
The Brood
and concludes with a speculative reimagining that attends to the utter lack of care Nola receives as she struggles to extricate herself from intergenerational neglect and abuse.
MODEL OF TRANSPORT SAFETY ASSESSMENT IN MULTIMODAL TRANSPORTATION SYSTEMS
Authors: Cherednichenko Kostiantyn , Ivannikova Viktoriia , Sokolova Olena , Yanchuk Maryna
Published: February 2024

In this paper methods, criteria and models of safety assessment of multimodal transportation systems are investigated. Today, new types of transportation systems are formed – multimodal transportation systems, which may be defined as the result of the synthesis of several transport systems, where different modes of transport are effectively interact. The need for such systems was formed due to the peculiarities of each mode of transport, its technological and technical characteristics, which restrain the ability to compete and promote transport interaction. In this context, the problem of transport safety assess of multimodal freight transportations becomes highly important. An analysis of modern scientific researches on topic of transport safety is conducted. Unfortunately, the considered approaches to transport safety have a set of disadvantages if the complex systems are considered in form of, for example, combined, multimodal or intermodal transportations: the problem of local optimum; the problem of safety management in case of transport company is not the actual infrastructure owner; the problem of unifying estimates for several modes of transport, and so on. The system’s safety depends on its integrity and sustainable development, which is directly dependent on the objective conditions of its formation, development and operation. At the same time, the state of safety is directly dependent on subjective factors, the purpose of which is to ensure security, i.e., to preserve the integrity and maintain sustainable development and optimal functioning of the system. Thus, there is a conditional field of protection of transport system objects, which provides counteraction to a set of existing or perceived threats. In this context, modelling the transport safety assessment of multimodal freight is relevant and requires appropriate scientific developments. In the research, methods of mathematical modelling of transport systems were used in order to develop methodological approach that could be potentially used in improving the multimodal freight transportation safety. A methodical approach to safety assessment on the example of multimodal transportation, which takes into account the drawbacks of existing studies, is proposed. The practical application of developed model was demonstrated on the existing system of multimodal transportation. The developed safety assessment method may be potentially used both to assess the transportation route safety level and as key factor in optimal transportation route designing.
Surgically Induced Scleritis Associated With Suture Hypersensitivity Following Strabismus Surgery
Authors: Lee Patrick S.Y. , Freedman Ryan L. , Abrams Gary , Lin Xihui , Bahl Reecha S.
Published: February 2024

A 67-year-old woman with history of mild suture hyper-sensitivity presented with localized scleritis after strabismus surgery. After infection was ruled out, the patient was prescribed topical and systemic non-steroidal anti-inflammatory drugs and systemic steroids, which led to full clinical resolution.

[
J Pediatr Ophthalmol Strabismus
. 2024;61(1):e4–e6.]
The new soliton solution types to the Myrzakulov-Lakshmanan-XXXII-equation
Authors: Zahran Emad H. M. , Bekir Ahmet , Ibrahim Reda A. , Myrzakulov Ratbay
Published: February 2024

Our attention concenters on deriving diverse forms of the soliton arising from the Myrzakulov-Lakshmanan XXXII (M-XXXII) that describes the generalized Heisenberg ferromagnetic equation. This model has been solved numerically only using the N-fold Darboux Transformation method, not solved analytically before. We will derive new types of the analytical soliton solutions that will be constructed for the first time in the framework of three impressive schemas that are prepared for this target. These three techniques are the Generalized Kudryashov scheme (GKS), the (G'/G)-expansion scheme and the extended direct algebraic scheme (EDAS). Moreover, we will establish the 2D, 3D graphical simulations that clear the new dynamic properties of our achieved solutions.
Effect of a bioinspired upstream extended surface profile on flow characteristics and a drag coefficient of a circular cylinder
Authors: Bhuiyan Shorob Alam , Hossain Ikram , Hossain Redwan , Abir Md. Sakib Ibn Mobarak , Ahmed Dewan Hasan
Published: February 2024

In the current work, the passive drag reduction of a circular cylinder for the subcritical Reynolds number range of 5.67×104 to 1.79×105 was computationally and experimentally investigated. First, inspired by nature, the aerodynamic drag coefficient of a whole Peregrine Falcon was measured in a subsonic wind tunnel for various angles of attack and Reynolds numbers (Re) and compared with the bare cylinder. At a 20° angle of attack and Re = 5.67×104, the whole falcon model had a 75% lower drag coefficient than the bare cylinder. Later, with the moderate Falcon model, in which the falcon's beak and neck were linked to the cylinder as an extended surface, the drag coefficient decreased up to 72% in the subcritical Reynolds number zone. Finally, the extended surface with a falcon beak profile was connected to the cylinder with a stem and investigated both numerically and experimentally for various stem lengths, angles of attack, and Reynolds numbers. It was found that at low Re, the drag coefficient can be reduced by up to 47% for the stem length of 80 mm (L/D = 1.20) with an angle of attack 10°. The computational investigation yielded precise flow characteristics, and it was discovered that the stem length and the Re had a substantial influence on vortex generation and turbulent kinetic energy between the beak and cylinder, as well as downstream of the cylinder. Investigation revealed that percentile drag reduction was much lower for the whole Falcon model over a wide range of Reynolds numbers and positive angles of attack, which exist in nature. Similarly, when compared to the other stem lengths, the 60 mm stem length (L/D = 0.97) produced similar results to the whole Falcon model. The numerical results were well validated with the experimental results.
Economy of Nature as the Logic of Government
Authors: Piasentier Marco
Published: February 2024

The aim of this paper is to show that Foucault’s genealogy of liberal governmentality necessitates reconsideration in light of the history of biology and its societal implications. In his lectures at the Collège de France in the late 1970s, Foucault argued that the natural growth of the market is what ultimately verifies or falsifies the excellence of liberal governmentality. Liberal governmentality recognizes the intimate correlation between the physical and social dimensions in order to adapt its political action to the natural processes of the market. It follows that liberal governmentality rests upon a certain kind of naturalism and the knowledge that defines this form of naturalism is political economy, which explicates both the foundations and the limits of governmental action in the name of the nature of the market. Foucault thus accords significant importance to the concept of nature in liberal governmentality. However, his genealogy is confined to an inquiry into the naturalism of classical political economy, without considering the economicism of the emerging biological sciences. To expand upon Foucault’s genealogy, the present paper focuses on the influence of political economy in the development of the theory of evolution by natural selection. The locution “economy of nature” is introduced to denote the discursive formation that brings together the naturalism of classical political economy and the economism of early evolutionary biology. This study contends that this construct played a critical role in shaping liberal governmentality.
Unspeakable
Authors: Bradley Arthur
Published: February 2024

In order to speak in the voice of “the pervert,” psychoanalysis inevitably find itself performing the classic rhetorical act of prosopopoeia whereby an imagined, absent, or dead person is represented as speaking. To re-read Jacques-Alain Miller’s classic essay “On Perversion” (1996), for example, we find that the pervert is adjudged to be “unspeakable”—in every sense of that word—and so they can only be ventriloquized by the figure of the analyst. If the analyst seeks to speak on behalf of the pervert, however, this essay argues that the perverse speech act is itself a form of prosopopoeia which can ventriloquize the subject position of the hysteric, the neurotic, the psychotic, and even the analyst themselves. In conclusion, the essay argues that Miller’s account of the relationship between the analyst and the pervert, where each are seen to ventriloquize the other, bespeaks of a certain prosopopophilia—a love of prosopopoeia—that is the condition of being a speaking subject in the first place: I am always speaking for and as the other—even or especially when I am speaking as “myself.”
Dialectic of the Limit
Authors: Rasmussen Holden M.
Published: February 2024

In a series of presentations at Sainte-Anne Hospital, published in English under the title Talking to Brick Walls, Lacan offers one of the few explicit references to Bataille in his œuvre. He interposes a stark disagreement between himself and Bataille on the status of possible knowledge regarding ontological questions. Lacan reads Bataille as a mystic who proposes that the pursuit of knowledge is a futile task and that knowledge of being is only possible per viam negativam. In order to advance this reading, Lacan emphasises Bataille’s fixation with “nonknowledge.” At first glance, one can understand why Lacan identifies him as a mystic, and many commentators on Bataille’s writings offer similar reading; however, this ignores subtle nuances of Bataille’s arguments regarding what he calls “inner experience.” More crucially, it ignores his explicit rejection of mysticism on the very basis of the knowledge that results from nonknowledge. This comparison frames a problem for fundamental ontology, of which I hope to elaborate only one aspect: The incompleteness of thought implies a non-relation between thought and being, and we can have a knowledge about this non-relation through an analysis of the limit as phantasmatic and structural rather than as real.
Haptic Contagion
Authors: Komel Mirt
Published: February 2024

During the pandemic there were many ways of handling the contagious SARS-CoV-2 virus, most of them in haptic terms, or in terms of touch: masks, hand disinfection, social distancing, quarantines, (self)isolations. Touch thus became not only the privileged object of the new bio-politics, striving to preserve life at all costs, but also what was lost during the pandemic. To be sure, a loss of something we never had that even the vaccine, which promised a return to normal, but actually paved the way for a “brave new post-pandemic world,” could not rehabilitate. In short, one of the elements that radically changed with and in the (post-)pandemic world is precisely the elusive object of touch, which we propose to conceptually grasp through the coinage of the concept of its “mateReal hapticity.”
Engineering and geomorphological map of Irpin: significance for engineering geological zoning and evaluation of the city construction
Authors: Zhyrnov Pavlo , Solomakha Iryna
Published: February 2024

The scheme of engineering-construction evaluation, which is created based on engineering geological zoning of city territories, is necessary among additional graphic materials in the design of master plan projects, as determined by state building codes. Engineering geological zoning provides a selection of different taxonomic units, having particular engineering and geological conditions that ultimately determine construction sites to a specific suitability category. A variant of synthetic large-scale engineering and geomorphological mapping applied to Irpin (Kyiv region, Ukraine) is built based on morphogenetic, morpholithologic, morphometric and morphodynamic data. The results enabled to determine different rank taxons of engineering and geological zoning, including small ones such as engineering and geological subdistricts according to their morphologic characteristics, and engineering and geological second order sites according to morphometric indexes. The results of engineering geomorphological mapping provided (i) an opportunity to determine the morphologic and morphogenetic conditions of Irpin, (ii) natural hazards spatial extent on new areas, and (iii) indications on relief elements that complicate the construction development. The assessment has become an ultimate result for both the complexity of engineering geomorphological conditions and geomorphological factors for the appropriate creation of construction evaluation scheme’s and corresponding measures’ selection of engineering training; such an assessment is also essential for the protection of Irpin territory and its problematic construction sites.
Suivi citoyen des indicateurs des aléas d’érosion côtière et de submersion marine : création de l’application smartphone et tablette CoastAppli et expérimentation à Guissény (Finistère)
Authors: Letortu Pauline , Ruault Riwalenn , Rouan Mathias , Millière Quentin , Derval Jean-Marie , Gall Valérie Ar , Chorlay Dominig , Floch Noémie , Loncle Nicolas , Hénaff Alain , Dantec Nicolas Le , Philippe Manuelle , David Laurence , Maulpoix Adeline , Ammann Jérôme
Published: February 2024

Les aléas côtiers (érosion, submersion, migration dunaire) et les dynamiques côtières sont souvent méconnus par le grand public. Or, dans un contexte de changement climatique et d’évolution de la législation (loi « Climat et résilience » en 2021) sur la gestion des aléas et des risques côtiers (risque(s) combinant aléa(s) et enjeu(x)), le suivi de l’évolution du littoral au travers d’indicateurs des aléas côtiers (position du trait de côte, niveau de la plage, niveau d’eau sur un repère lors d’une submersion, etc.) devrait être l’affaire de tous. Jusqu’à présent, aucune application citoyenne pour smartphone ou tablette ne permettait de suivre conjointement les indicateurs des aléas côtiers d’érosion et de submersion, alors que ces deux aléas sont souvent liés. Pour y remédier, dans le cadre d’un projet de recherche et de formation (2019-2022) regroupant des étudiants en géographie, en biologie et en informatique, nous avons créé l’application Android CoastAppli. CoastAppli, qui vise un public large (habitants, touristes, scolaires, gestionnaires du littoral, etc.) et a été expérimentée à Guissény (Finistère) entre janvier et octobre 2022 auprès de 86 personnes, permet de réaliser un suivi citoyen des indicateurs d’aléas côtiers. Grâce à l’implication des utilisateurs sur les quatre sites de cette commune, les résultats soulignent la fiabilité des données quantitatives (jusqu’à une erreur globale de ± 4 cm) et/ou qualitatives, ainsi que la haute fréquence d’acquisition (mensuelle). Par ailleurs, cela semble un bon moyen pour comprendre, discuter et réfléchir entre acteurs du territoire aux défis de gestion du littoral d’aujourd’hui et de demain.
Apocrine gland adenoma in a 4-month old golden hamster (Mesocricetus auratus)
Authors: Manathunga M. T. A. , Arunasalam S. , Wickramasinghe K. W. D. M. Y. W. , Piyadasa T. M. S. K. , Ariyarathna H.
Published: February 2024

Hamsters are popular as pets. Although there are many reports on tumours in laboratory hamsters, tumours in pet hamsters are infrequently reported. The present report describes successful diagnosis, treatment and treatment outcome of apocrine gland adenoma, an uncommon cutaneous neoplasm, identified in the ventral neck region of a 4-month old Golden hamster (Mesocricetus auratus). The initial diagnosis was attempted by cytology. The cytology of benign apocrine glands in hamsters has not been previously described in the literature. Histopathology of the neoplasm was consistent with an apocrine adenoma and positive PAS staining confirmed the secretory nature of the neoplasm. The tumour was surgically excised under local anaesthesia. There was no tumour recurrence or metastasis detected after one year.
Beyond the GCS: an integrative review of new tools for neurological assessment in the intensive care unit for adult patients
Authors: Xhaferri Alessia , Ramacciati Nicola , Giusti Gian Domenico
Published: February 2024

The Glasgow Coma Scale (GCS) is a widely used clinical tool for assessing impaired consciousness, but concerns arise when applied to intubated patients or those receiving analgesics, sedatives, and paralytics because verbal scores are not evaluable. Furthermore, the GCS does not differentiate the neurological status of the patient once intubated, resulting in poor reliability in neurological assessment, and clinical indicators that may reflect the severity of the coma are not included in the GCS. This study explores alternative tools for neurological assessment in Intensive Care Units (ICUs) when GCS is impractical. Conducting an integrative review of studies from 2018 to 2022, we identified seven relevant papers. Results indicate the FOUR score as a promising GCS alternative, particularly in cases where the GCS is unavailable. Automated pupillometry also demonstrated the potential for monitoring neurologically impaired ICU patients. These tools, independent of verbal responses and applicable to sedated patients, offer improved accuracy in assessing consciousness. The study emphasizes the importance of adopting such alternatives, and addressing GCS limitations, and highlights the need for further research and implementation to enhance patient care in ICU settings.
Targeting oxidative stress with natural products: A novel strategy for esophageal cancer therapy
Authors: Cao Fang , Zhang Han-Ling , Guo Cui , Xu Xue-Liang , Yuan Qiang
Published: February 2024

Esophageal cancer (ESC) is a malignant tumor that originates from the mucosal epithelium of the esophagus and is part of the digestive tract. Although the exact pathogenesis of ESC has not been fully elucidated, excessive oxidative stress is an important characteristic that leads to the development of many cancers. Abnormal expression of several proteins and transcription factors contributes to oxidative stress in ESCs, which alters the growth and proliferation of ESCs and promotes their metastasis. Natural compounds, including alkaloids, terpenes, polyphenols, and xanthine compounds, can inhibit reactive oxygen species production in ESCs. These compounds reduce oxidative stress levels and subsequently inhibit the occurrence and progression of ESC through the regulation of targets and pathways such as the cytokine interleukins 6 and 10, superoxide dismutase, the NF-+ACY-kappa+ADs-B/MAPK pathway, and the mammalian Nrf2/ARE target pathway. Thus, targeting tumor oxidative stress has become a key focus in anti-ESC therapy. This review discusses the potential of Natural products (NPs) for treating ESCs and summarizes the application prospects of oxidative stress as a new target for ESC treatment. The findings of this review provide a reference for drug development targeting ESCs. Nonetheless, further high-quality studies will be necessary to determine the clinical efficacy of these various NPs.
Preoperative controlling nutritional status as an optimal prognostic nutritional index to predict the outcome for colorectal cancer
Authors: Liu Li-Xiang , Wang Hao , Gao Bo , Xu Ting-Ting , Yuan Qing-Gang , Zhou Shi-Zhen , Ding Chao , Miao Ji , Guan Wen-Xian
Published: February 2024

BACKGROUND

The controlling nutritional status (CONUT) score effectively reflects a patient’s nutritional status, which is closely related to cancer prognosis. This study investigated the relationship between the CONUT score and prognosis after radical surgery for colorectal cancer, and compared the predictive ability of the CONUT score with other indexes.

AIM

To analyze the predictive performance of the CONUT score for the survival rate of colorectal cancer patients who underwent potentially curative resection.

METHODS

This retrospective analysis included 217 patients with newly diagnosed colorectal. The CONUT score was calculated based on the serum albumin level, total lymphocyte count, and total cholesterol level. The cutoff value of the CONUT score for predicting prognosis was 4 according to the Youden Index by the receiver operating characteristic curve. The associations between the CONUT score and the prognosis were performed using Kaplan-Meier curves and Cox regression analysis.

RESULTS

Using the cutoff value of the CONUT score, patients were stratified into CONUT low (n = 189) and CONUT high groups (n = 28). The CONUT high group had worse overall survival (OS) (P = 0.013) and relapse-free survival (RFS) (P = 0.015). The predictive performance of CONUT was superior to the modified Glasgow prognostic score, the prognostic nutritional index, and the neutrophil-to-lymphocyte ratio. Meanwhile, the predictive performances of CONUT + tumor node metastasis (TNM) stage for 3-year OS [area under the receiver operating characteristics curve (AUC) = 0.803] and 3-year RFS (AUC = 0.752) were no less than skeletal muscle mass index (SMI) + TNM stage. The CONUT score was negatively correlated with SMI (P < 0.01).

CONCLUSION

As a nutritional indicator, the CONUT score could predict long-term outcomes after radical surgery for colorectal cancer, and its predictive ability was superior to other indexes. The correlation between the CONUT score and skeletal muscle may be one of the factors that play a predictive role.
Effect of different anesthetic modalities with multimodal analgesia on postoperative pain level in colorectal tumor patients
Authors: Tang Ji-Chun , Ma Jia-Wei , Jian Jin-Jin , Shen Jie , Cao Liang-Liang
Published: February 2024

BACKGROUND

According to clinical data, a significant percentage of patients experience pain after surgery, highlighting the importance of alleviating postoperative pain. The current approach involves intravenous self-control analgesia, often utilizing opioid analgesics such as morphine, sufentanil, and fentanyl. Surgery for colorectal cancer typically involves general anesthesia. Therefore, optimizing anesthetic management and postoperative analgesic programs can effectively reduce perioperative stress and enhance postoperative recovery. The study aims to analyze the impact of different anesthesia modalities with multimodal analgesia on patients' postoperative pain.

AIM

To explore the effects of different anesthesia methods coupled with multi-mode analgesia on postoperative pain in patients with colorectal cancer.

METHODS

Following the inclusion criteria and exclusion criteria, a total of 126 patients with colorectal cancer admitted to our hospital from January 2020 to December 2022 were included, of which 63 received general anesthesia coupled with multi-mode labor pain and were set as the control group, and 63 received general anesthesia associated with epidural anesthesia coupled with multi-mode labor pain and were set as the research group. After data collection, the effects of postoperative analgesia, sedation, and recovery were compared.

RESULTS

Compared to the control group, the research group had shorter recovery times for orientation, extubation, eye-opening, and spontaneous respiration (P < 0.05). The research group also showed lower Visual analog scale scores at 24 h and 48 h, higher Ramany scores at 6 h and 12 h, and improved cognitive function at 24 h, 48 h, and 72 h (P < 0.05). Additionally, interleukin-6 and interleukin-10 levels were significantly reduced at various time points in the research group compared to the control group (P < 0.05). Levels of CD3+, CD4+, and CD4+/CD8+ were also lower in the research group at multiple time points (P < 0.05).

CONCLUSION

For patients with colorectal cancer, general anesthesia coupled with epidural anesthesia and multi-mode analgesia can achieve better postoperative analgesia and sedation effects, promote postoperative rehabilitation of patients, improve inflammatory stress and immune status, and have higher safety.
Immune-related long noncoding RNA zinc finger protein 710-AS1-201 promotes the metastasis and invasion of gastric cancer cells
Authors: Ding Wei , Chen Wei-Wei , Wang Yi-Qin , Xu Xue-Zhong , Wang Yi-Bo , Yan Yong-Min , Tan Yu-Lin
Published: February 2024

BACKGROUND

Gastric cancer (GC) is a prevalent malignant tumor of the gastrointestinal system. ZNF710 is a transcription factor (TF), and zinc finger protein 710 (ZNF710)-AS1-201 is an immune-related long noncoding RNA (lncRNA) that is upregulated in GC cells.

AIM

To assess the correlation between ZNF710-AS1-201 and immune microenvironment features and to investigate the roles of ZNF710-AS1-201 in the invasion and metastasis processes of GC cells.

METHODS

We obtained data from The Cancer Genome Atlas and Wujin Hospital. We assessed cell growth, migration, invasion, and programmed cell death using cell counting kit-8, EdU, scratch, Transwell, and flow cytometry assays. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to identify the potential downstream targets of ZNF710-AS1-201.

RESULTS

In GC tissues with low ZNF710-AS1-201 expression, immunoassays detected significant infiltration of various antitumor immune cells, such as memory CD8 T cells and activated CD4 T cells. In the low-expression group, the half-maximal inhibitory concentrations (IC50s) of 5-fluorouracil, cisplatin, gemcitabine, and trametinib were lower, whereas the IC50s of dasatinib and vorinostat were higher. The malignant degree of GC was higher and the stage was later in the high-expression group. Additionally, patients with high expression of ZNF710-AS1-201 had lower overall survival and disease-free survival rates. In vitro, the overexpression of ZNF710-AS1-201 greatly enhanced growth, metastasis, and infiltration while suppressing cell death in HGC-27 cells. In contrast, the reduced expression of ZNF710-AS1-201 greatly hindered cell growth, enhanced apoptosis, and suppressed the metastasis and invasion of MKN-45 cells. The expression changes in ZNF710 were significant, but the corresponding changes in isocitrate dehydrogenase-2, Semaphorin 4B, ARHGAP10, RGMB, hsa-miR-93-5p, and ZNF710-AS1-202 were not consistent or statistically significant after overexpression or knockdown of ZNF710-AS1-201, as determined by qRT-PCR.

CONCLUSION

Immune-related lncRNA ZNF710-AS1-201 facilitates the metastasis and invasion of GC cells. It appears that ZNF710-AS1-201 and ZNF710 have potential as effective targets for therapeutic intervention in GC. Nevertheless, it is still necessary to determine the specific targets of the ZNF710 TF.
Anti-EGFR antibody monotherapy for colorectal cancer with severe hyperbilirubinemia: A case report
Authors: Tsurui Toshiaki , Hirasawa Yuya , Kubota Yutaro , Yoshimura Kiyoshi , Tsunoda Takuya
Published: February 2024

BACKGROUND

Hyperbilirubinemia with hepatic metastases is a common complication and a poor prognostic factor for colorectal cancer (CRC). Effective drainage is often impossible before initiating systemic chemotherapy, owing to the liver’s diffuse metastatic involvement. Moreover, an appropriate chemotherapeutic approach for the treatment of hyperbilirubinemia is currently unavailable.

CASE SUMMARY

The patient, a man in his 50s, presented with progressive fatigue and severe jaundice. Computed tomography revealed multiple hepatic masses with thickened walls in the sigmoid colon, which was pathologically confirmed as a well-differentiated adenocarcinoma. No RAS or BRAF mutations were detected. The Eastern Cooperative Oncology Group (ECOG) performance status (PS) score was 2. Biliary drainage was impossible due to the absence of a dilated bile duct, and panitumumab monotherapy was promptly initiated. Subsequently, the bilirubin level decreased and then normalized, and the patient’s PS improved to zero ECOG score after four cycles of therapy without significant adverse events.

CONCLUSION

Anti-EGFR antibody monotherapy is a safe and effective treatment for RAS wild-type CRC and hepatic metastases with severe hyperbilirubinemia.
Efecto del periodo de días en alimentación para alcanzar el peso al sacrificio sobre características productivas, rendimiento de la canal y cortes y calidad de la carne de ovinos criollos alimentados con raciones totales
Authors: Rodríguez-Carías Abner A. , Bayne Alana , Rivera Aixa , Duckett Susan
Published: February 2024

Se comparó el efecto del periodo de días en alimentación (DIA) para alcanzar el peso al sacrificio sobre características productivas, rendimiento de la canal caliente y fría y rendimientos de cortes primarios y al detal de corderos criollos alimentados en confinamiento con raciones totales (RT). La calidad de la carne incluyendo el perfil de ácidos grasos también fue determinada. La RT conteniendo 70% de alimento concentrado y 30% heno de gramíneas tropicales se ofreció al 4.5% del peso vivo del cordero en base seca hasta lograr determinar los DIA para alcanzar un peso al sacrificio de 20 a 25 kg (PS1) o de 46 a 50 kg (PS2). Tres jaulas con cuatro ovinos criollos de cinco a siete meses se utilizaron como unidades experimentales durante el periodo de DIA para alcanzar el PS1 y dos animales por jaula durante los DIA para alcanzar el PS2. En cada periodo de DIA se cuantificó el consumo voluntario (CV) por jaula de los corderos. Para determinar la ganancia en peso diaria (GPD) por animal y la conversión alimenticia (CA) por jaula, los corderos se pesaron semanalmente. Al obtener el PSI y PS2, seis corderos de cada peso se sacrificaron en un matadero comercial para determinar el rendimiento de la canal caliente (RCC) y fría (RCF), y el rendimiento de cortes primarios y al detal con relación al peso de la canal fría. Los cortes primarios evaluados fueron nuca (N), costilla 1-5/pernil delantero (CPD), costillas 6-13
PERLINDUNGAN HAK EKONOMI TERHADAP LAGU TUHU LA AKU BUAL LAGU YANG DICOVER DALAM CHANEL YOUTUBE
Authors:   Universitas Negeri Medan, Siburian Yeremia Elkana Tua , Siregar Salsabila Balqis , Sihombing Grace Michael , Peranginangin Reh Bungana Beru , Siahaan Parlaungan Gabriel
Published: February 2024

Karo songs are works of art created from the Karo language, literature, as well as music and singers. Each word has a specific meaning to convey to the audience, namely the listener/viewer. Economic rights are understood as the right to obtain profits from the creation of a song. This research is an empirical qualitative method, using empirical data collection and in-depth interpretation. The methods used include in-depth interviews and participant observation, the result is that the economic rights of Karo language songs on YouTube are protected, but many individuals also use other people's works for commercial purposes. The protection given to economic rights can be complained of if the content owner reports violations even though copyright ownership has been registered. This is because economic rights adhere to the complaint offense system. Complaints can be submitted through litigation channels, namely the Commercial Court, and also non-litigation channels, namely to the Press council.
PERANCANGAN APLIKASI PENILAIAN KINERJA KEPALA LINGKUNGAN KECAMATAN MEDAN HELVETIA DENGAN METODE GRS & 360 DEGREES BERBASIS ANDROID
Authors:   STMIK TIME, Tarigan Feriani Astuti
Published: February 2024

Performance appraisal is an important part of seeing the results of each employee's work performance, including the Head of the Neighborhood who is the spearhead of Government services to the community. However, the Head of Neighborhood has not found a standardized performance appraisal so that the author is interested in making a performance appraisal system for the Head of Neighborhood, especially in Medan Helvetia District and at the same time building an easy-to-use assessment application. This Neighborhood Head Performance Assessment Application uses a combination of the Graphic Rating Scale (GRS) algorithm to make it easier to see the assessment results and the 360 Degrees algorithm so that the assessment results are more objective. The assessment results obtained can be a recommendation for reward and punishment. The application also requires development to iOS-based smartphones so that more users can utilize it.
Voice-Based Sinhala Document Maker Application
Authors: Dissanayaka D.D.D. , Jayasundara J.M.O.K. , De Silva Dr. Dilshan
Published: February 2024

This research paper introduces "Word Sri," an inventive voice-based web application designed to enhance written Sinhala communication and originality. The application incorporates features such as a plagiarism checker, grammar checker, voice-activated punctuation, and intuitive voice commands in an effort to accommodate a diverse user base, including individuals with disabilities, language learners, writers, journalists, students, and professionals. The first aspect of the paper explores the creation of a user-friendly Sinhala Grammar Checker with Fix Sentences & Punctuation, addressing the dearth of effective language tools for grammar, punctuation, and orthography correction. Using a comprehensive analysis of Sinhala language components, literature, and a corpus of text data, the model provides students, academicians, and professionals with real-time error feedback and correction. The second aspect highlights the distinctive characteristics of the "Word Sri" application, emphasizing its usefulness for voice-based Sinhala content creation. Notably, the application includes a cutting-edge Sinhala plagiarism analyzer that uses machine learning algorithms, synonym and paraphrase detection to improve the originality of content. This research represents a significant advancement in Sinhala language technology, as it provides a unified platform for efficient voice-based typing, accurate grammar checks, and plagiarism detection, thereby facilitating effective written communication and originality in Sinhala for global users.
Machine Learning Based Customized Solution for Deafness and Mute People
Authors: Silva Suranjini , Jayalath Thilini , E.A.Y.C. Madhushani , H.D. Amarasooriya , S.N. Elpitiya , Perera Frank
Published: February 2024

Individuals with hearing or speech impairments often possess a higher degree of familiarity with sign language due to its widespread usage. Consequently, a noticeable communication divide exists between those with such impairments and the general populace. A pivotal solution in bridging this gap involves employing human sign language interpreters. Regrettably, the scarcity of sign language interpreters worldwide in comparison to the number of individuals with hearing or speech impairments has resulted in certain individuals being unable to bear the cost of a human interpreter each time they engage in conversation. To address this issue, it is imperative to automate communication in a manner that liberates the deaf community from dependence on human translators. This article centers on the development of an application capable of real-time conversion between American Sign Language and text, along with supplementary functionalities aimed at dismantling the communication barriers faced by individuals with hearing or speech challenges when interacting with the broader public. the primary objective of this application is to accurately perceive and interpret the user's sign language. The initial stage involves training the system to recognize and interpret signs utilizing algorithms for object recognition and motion tracking. For this purpose, a convolutional neural network model was trained employing a meticulously curated American Sign Language dataset. Subsequently, the recognized signs are translated into English, forming grammatically sound words. Incorporated within the system are a language translator and a virtual sign keyboard, augmenting its capabilities. Moreover, a text-to-text transformer, structured on an encoder-decoder framework, is harnessed to identify grammatical inaccuracies and generate coherent phrases. For a comprehensive understanding of the process, detailed elaboration will follow in subsequent sections.
PDMS-Based U-Slotted Patch and Meander Line Antennas for Search and Rescue Applications
Authors: Mirza Hidayath , Sheikh Rais Ahmad , Chauhan Deepa , Rajan Preethi , Sultana Nishat , Jamlos Mohd Aminudin
Published: February 2024

This study focuses on the development of a low-profile meander line-based antenna as well as a U-slotted patch antenna that was built specifically for the requirements of search and rescue operations. Both of these antennas serve as the primary focus of this investigation. Both the meander line antenna and the U-slotted patch antenna that are being considered are planned to be constructed on a substrate that is made of polydimethylsiloxane (PDMS). PDMS is selected because of its desired features, which include its durability, flexibility, resistance to water, and adaptability for deployment in demanding environmental circumstances. The usage of the search and rescue application necessitates the operation at a relatively lower frequency of 406 MHz, which in turn necessitates the utilization of antennas that have a longer electrical length. As a consequence of this, these antennas have a propensity to have larger physical dimensions. In order to circumvent the problem, it is possible to make use of U-Slotted Patch and Meander Line Antennas, which will result in a smaller dimension. This was proved by the results of the simulation, which showed that the antenna functioned at a central frequency of 406 MHz, displaying a bandwidth of 40.5 MHz for the U-slotted patch antenna and 67.49 MHz for the meander line antenna, respectively. Concerning the two antennas, these bandwidths were equivalent to a fractional bandwidth percentage of 9.9% and 16.55%, respectively, when evaluated at -10 dB of the reflection coefficient.
Historical urban planning analysis of the Kama and Toima riverside areas (on the example of the city of Elabuga in the 19TH -20TH century)
Authors:   Saint-Petersburg State University of Architecture and Civil Engineering, Agafonova Ekaterina A.
Published: February 2024

In cities on large rivers, increasing attention is being given to coastal areas as the basis for their sustainable development. At the same time, most of the development proposals are too radical and require significant financial investments that are not available in small cities. To make the right decisions, a historical urban-planning analysis is required to identify the reasons for the decline of coastal areas, and further arguments are needed in support of decisions for their transformation. This study is an attempt to verify the statement that the sustainable development of coastal areas should take into account the previous evolutionary trends, and their development needs to be monitored regularly in order to make timely adjustments to their functional zoning. Using the example of the old city of Elabuga located on two rivers, Kama and Toima, the main reasons influencing its zoning are highlighted. Depending on momentary interest in a particular function, it may either evolve and flourish or fall in decline, but is never completely driven out. Based on the analysis, a potential path for the development of coastal areas is identified by raising social interest and demand for historical functions through their renovation, additions, and improvement of accessibility.
The morphology of the visual urban space of Komsomolsk-on-Amur: the path from soviet to modern
Authors:   Komsomolsk-on-Amur State University, Dimitriadi Ekaterina M.
Published: February 2024

The morphology of city visual space is examined using Komsomolsk-on-Amur as an example. This study is currently relevant considering the need to understand the visual perception of space and the uniqueness of the urban environment. The visual morphology of the city is defined as a part of visual urban studies. The morphology of the visual space of Komsomolsk-on-Amur within the framework of a visual model of the urban structure is revealed through the fundamental category of time, which determines the nature of the historical, cultural and visual space. The history of the city is considered focusing on the main stages in the formation of the socio-cultural space that influenced the image of the city. The current urban space of Komsomolsk-on-Amur is analyzed. Cultural historical analysis allowed us to identify the positive and negative aspects of its visual space. Recommendations are offered for the formation of a visually informative urban environment of Komsomolsk-on-Amur using student works as examples.
Geomedia. Postindustrial practices of public space improvement in Arctic cities
Authors:   Vologda State University, Vinogradova Svetlana. L. , Rybakov Sergey N. ,   Vologda State University
Published: February 2024

Architecture is the most important tool for transforming the environment. According to S. McQuire, today, the advent of media technologies creates a new “modality”, which turns architecture into a dynamic media product. The article considers the Arctic as a potential space for the application of media architecture and media technologies, emphasizing the possibility of using these tools to solve the unique environmental and socio-economic problems of the region. The Arctic is regarded is a “territory of the future”, where the new media architecture design approaches may have an impact on the environment. The possibility of implementing media architectural practices in different contexts is discussed, particularly in the Arctic, where a number of problems can be solved with the help of these new tools.
Soviet heritage: clubs, palaces of culture, and other cultural buildings of Kamensk-Uralsky erected in the 1930-1960s.
Authors:   ‘Bank of Cultural Information’ Publisher, Gavrilova Svetlana I.
Published: February 2024

The article provides a historical and architectural review of the unique heritage of the Soviet era - the clubs and palaces of culture of Kamensk-Uralsky, an industrial city in the Urals, Russia. Changes in the architectural style of these buildings and their use in connection with the changing political situation in the country are retraced.
Morphometric and Phenotypic Characterization of Pote Goats in Soket Laok Village, Tragah District, Bangkalan Regency, Madura
Authors:   Postgraduate Student Program Faculty of Animal Science, Brawijaya University, Malang, Jawa Timur, 551661, Husna Imaniah Nida’ul , Susilorini Tri Eko ,   Lecturer of Postgraduate Program Faculty of Animal Science, Brawijaya University, Malang, Jawa Timur, 551661, Kuswati Kuswati ,   Lecturer of Postgraduate Program Faculty of Animal Science, Brawijaya University, Malang, Jawa Timur, 551661, Adiningsih Farah ,   Postgraduate Student Program Faculty of Animal Science, Brawijaya University, Malang, Jawa Timur, 551661, Nuraeni Dina ,   Postgraduate Student Program Faculty of Animal Science, Brawijaya University, Malang, Jawa Timur, 551661
Published: February 2024

The purpose of this study was to analyze the morphometric characteristics of Pote goats in Soket Laok Village, Madura Island. The material used was 200 Pote goats with an age range from over 1 year (PI0>6) to more than 3.5 years (PI8). The sample included 90 goats aged over 1 year (PI0>6), 36 goats aged between 1 and 1.5 years (PI2), 54 goats aged between 1.5 and 2.5 years (PI4), 16 goats aged between 2.5 and 3.5 years (PI6), and 4 goats aged over 3.5 years (PI8). The method used is a survey method which includes conducting surveys and interviews. Data were obtained using a purposive sampling technique. The results showed that morphometric measurements on the head and body of Pote goats had the highest average at PI 8, which means that along with the increasing age of Pote goats, it will affect the body size of goats. The results of the dominant phenotypic characteristics of Pote goats are the shape of a pitcher udder, the shape of long drooping ears, the shape of flat horns, rectangular pupils, convex facial profiles, there is rewos hair both in males and females and there is no beard, and phenotypic Pote goats with different ages do not have significant differences.
An Update in the Management of “Frozen Abdomen”
Authors:   Hospital Regional de alta especialidad ISSSTE Veracruz, Barragán Alvaro de Jesús León , Cota García Raul Manuel ,   Hospital General de Ensenada, Secretaria de Salud del Estado de Baja California (https://orcid.org/0009-0009-0895-7038), Castañeda José Fernando Montiel ,   Hospital General de Ensenada, Secretaria de Salud del Estado de Baja California (https://orcid.org/0000-0003-0976-216X), Juarez Leon Alexis Rafael ,   Hospital Regional de alta especialidad ISSSTE Veracruz, Organista Sonia Elena Azucar ,   Universidad Autónoma de Guerrero. Facultad de Medicina, León Serna Rodrigo Rueda De ,   Hospital General "Dr. Ruben Leñero", Gallardo Aldair Cruz ,   Universidad Nacional Autonoma de Mexico (UNAM) CU. Facultad de Medicina, Cambero Oscar Gregorio Gonzalez ,   Universidad de Guadalajara, Centro Universitario de Ciencias de la Salud, Andrea Florián Espinosa Jiménez ,   Escuela Superior de Medicina, Instituto Politécnico Nacional
Published: February 2024

With a 0.5–3% incidence following initial closure of a laparotomy incision, wound dehiscence is a significant postoperative complication that signifies an abrupt mechanical failure of wound healing. Both clinical entities have common pathophysiological and clinical processes, as recently as the idea of "intentional open abdomen" was defined ("postoperative open abdominal wall"). While early restoration is the goal, a considerable number of patients may experience adhesions between the anterolateral abdominal wall and abdominal viscera; this condition is commonly referred to as "frozen abdomen," and the only practical option seems to be to postpone wound closure. We provide the "Coliseum technique" as the last surgical approach to treat it. This new method offers a creative substitute for abdominal exploration in situations with frozen abdomen that is considered "malignant" because of peritoneal carcinomatosis. Lifting the surgical wound's edges upward and suspending them from a retractor above the abdomen with threads makes it easier to approach the peritoneal cavity, maximizes the exposure of internal organs, and reduces the risk of operating-related damage to the blood supply and innervation of the abdominal wall muscles, which is an essential step for hernia repair later on..