bluuebunny/crossref_metadata_2025 huggingface dataset:
Spinal cord injury: global burden from 1990 to 2019 and projections up to 2030 using Bayesian age-period-cohort analysis
Authors: Liu Yanbo , Yang Xuesong , He Zhigang , Li Juan , Li Yijing , Wu Yanqiong , Manyande Anne , Feng Maohui , Xiang Hongbing
Published: December 2023

Background

Spinal cord injuries, often resulting from spine fractures, can lead to severe lifelong symptoms such as paraplegia and even mortality. Over the past few decades, there has been a concerning increase in the annual incidence and mortality rates of spinal cord injuries, which has also placed a growing financial strain on healthcare systems. This review aims to offer a comprehensive overview of spinal cord injuries by estimating their global incidence, prevalence, and the impact in terms of years lived with disability, using data obtained from the 2019 Global Burden of Disease Study.

Method

In this study, we utilized data from the 2019 Global Burden of Disease Study, a widely recognized source for global health data. Our methodology involved estimating the global incidence and prevalence of spinal cord injuries while also assessing the impact on years lived with a disability. We analyzed this data comprehensively to identify patterns and trends and made predictions.

Finding

This research delved into the evolving trends in the global burden of spinal cord injuries, identified key risk factors, and examined variations in incidence and disability across different Socio-demographic Index (SDI) levels and age groups. Briefly, in 2019, the global incidence and burden of YLDs of SCI significantly increased compared to 1990. While males had higher incidence rates compared to females. Falls were identified as the primary cause of SCI. Trend projections up to 2030 revealed a slight decrease in ASIR for males, an upward trend in age-specific incidence rates for both sexes and a similar pattern in age-standardized YLD rates. Additionally, our findings provided crucial groundwork for shaping future policies and healthcare initiatives, with the goal of mitigating the burden of spinal cord injuries, enhancing patient outcomes, and fortifying prevention efforts.

Interpretation

Understanding the global burden of spinal cord injuries is essential for designing effective healthcare policies and prevention strategies. With the alarming increase in prevalence rates and their significant impact on individuals and healthcare systems, this research contributes vital insights to guide future efforts in reducing the incidence of spinal cord injuries, improving the quality of life for affected individuals, and reducing the economic burden on healthcare systems worldwide.
Effect of carbohydrate restriction on body weight in overweight and obese adults: a systematic review and dose–response meta-analysis of 110 randomized controlled trials
Authors: Soltani Sepideh , Jayedi Ahmad , Abdollahi Shima , Vasmehjani Azam Ahmadi , Meshkini Fatemeh , Shab-Bidar Sakineh
Published: December 2023

Introduction

Carbohydrate-restricted diets are one of the most effective dietary interventions for weight loss. However, the optimum carbohydrate intake for implementing the most effective weight-loss interventions is still being discussed. We aimed to determine the optimum carbohydrate intake for short- and long-term weight loss in adults with overweight and obesity.

Methods

We searched PubMed, Scopus, Web of Science, and CENTRAL from inception to May 2021 for randomized controlled trials examining the effect of a carbohydrate-restricted diet (≤45% of energy intake) as compared to a control diet (carbohydrate intake >45% of energy intake) on body weight in adults with overweight/obesity. A random-effects dose–response meta-analysis was conducted to calculate the mean difference for each 10% decrease in carbohydrate intake at the 6-month follow-up (1 to 6 months), 12-month follow-up (6 to 12 months), and follow-up longer than 12 months. The shape of the dose-dependent effects was also evaluated. The certainty of the evidence was rated using the GRADE approach. The minimal clinically important difference (MCID) threshold was defined as 5% weight loss (equal to 4.39 kg).

Results

A total of 110 trials were selected for the present meta-analysis. In the linear dose–response meta-analysis, each 10% decrease in carbohydrate intake reduced body weight by 0.64 kg (95% CI: −0.79 to −0.49; n = 101 trials with 4,135 participants, high-certainty evidence) at the 6-month follow-up and by 1.15 kg (95% CI: −1.61 to −0.69; 42 trials with 2,657 participants, moderate-certainty evidence) at the 12-month follow-up. Non-linear dose–response meta-analyses indicated a monotonic reduction in body weight with the decrease in carbohydrate intake, with the greatest reduction at 5% at the 6-month follow-up (mean difference 5%: −3.96 kg, 95% CI: −4.92 to −3.00) and 10% at the 12-month follow-up (mean difference 10%: −6.26 kg, 95% CI: −10.42 to −2.10). At follow-up longer than 12 months, dose–response analyses suggested a non-linear effect, wherein carbohydrate intakes higher than 40% and lower than 30% were not effective for weight loss.

Discussion

Carbohydrate restriction is an effective dietary strategy for important weight loss in adults with overweight and obesity. At 6-month and 12-month follow-ups, body weight decreased proportionally, more than the MCID threshold, along with the decrease in carbohydrate intake. At follow-up longer than 12 months, there was a non-linear effect, with the greatest reduction at 30% carbohydrate intake.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42022315042.
Comparative efficacy and safety of systemic therapy for advanced hepatocellular carcinoma: a systematic review and network meta-analysis
Authors: Wu Di , Jia Binyang , Jia Muyuan , Zhao Haitao , Zhao Hong , Zhou Jinxue
Published: December 2023

Background

In recent years, there has been rapid development in systemic therapeutic agents for advanced hepatocellular carcinoma. However, most treatment modalities lack head-to-head comparisons, and the distinctions in their efficacy and safety have yet to be elucidated. Consequently, the accurate selection of a treatment regimen poses a significant challenge for clinicians.

Methods

This study incorporated twenty-three randomized controlled trials, encompassing fifteen first-line and eight second-line treatments, and involving a total of 14,703 patients with advanced hepatocellular carcinoma. Results: In the context of first-line treatment, it was observed that the combination of a PD-1 inhibitor with bevacizumab (1/15) significantly extended overall survival in patients with advanced HCC. Furthermore, PD-1 inhibitors combined with TKIs (1/15) and PD-1 inhibitors combined with bevacizumab (2/15) exhibited enhanced efficacy in reducing the risk of progression-free survival events. In second-line therapy, the network meta-analysis revealed that all investigational agents prolonged progression-free survival in patients with advanced hepatocellular carcinoma when compared to placebo. Cabozantinib ranked first (1/7) in this regard. However, this translated into an overall survival benefit only for cabozantinib, regorafenib, ramucirumab, and pembrolizumab, with regorafenib achieving the highest ranking (1/7).

Conclusion

In the treatment of advanced HCC, the immune checkpoint inhibitor combined with bevacizumab regimen and the immune checkpoint inhibitor combined with TKI regimen stand out as the two most effective first-line treatment options. It is noteworthy that, for patients with absolute contraindications to VEGF inhibitors, dual immunotherapy is the preferred choice. For second-line treatment, regorafenib and cabozantinib are identified as the two most effective options.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier CRD42023440173.
Towards detection of early response in neoadjuvant chemotherapy of breast cancer using Bayesian intravoxel incoherent motion
Authors: Cheung Sai Man , Wu Wing-Shan , Senn Nicholas , Sharma Ravi , McGoldrick Trevor , Gagliardi Tanja , Husain Ehab , Masannat Yazan , He Jiabao
Published: December 2023

Introduction

The early identification of good responders to neoadjuvant chemotherapy (NACT) holds a significant potential in the optimal treatment of breast cancer. A recent Bayesian approach has been postulated to improve the accuracy of the intravoxel incoherent motion (IVIM) model for clinical translation. This study examined the prediction and early sensitivity of Bayesian IVIM to NACT response.

Materials and methods

Seventeen female patients with breast cancer were scanned at baseline and 16 patients were scanned after Cycle 1. Tissue diffusion and perfusion from Bayesian IVIM were calculated at baseline with percentage change at Cycle 1 computed with reference to baseline. Cellular proliferative activity marker Ki-67 was obtained semi-quantitatively with percentage change at excision computed with reference to core biopsy.

Results

The perfusion fraction showed a significant difference (p = 0.042) in percentage change between responder groups at Cycle 1, with a decrease in good responders [−7.98% (−19.47–1.73), n = 7] and an increase in poor responders [10.04% (5.09–28.93), n = 9]. There was a significant correlation between percentage change in perfusion fraction and percentage change in Ki-67 (p = 0.042). Tissue diffusion and pseudodiffusion showed no significant difference in percentage change between groups at Cycle 1, nor was there a significant correlation against percentage change in Ki-67. Perfusion fraction, tissue diffusion, and pseudodiffusion showed no significant difference between groups at baseline, nor was there a significant correlation against Ki-67 from core biopsy.

Conclusion

The alteration in tumour perfusion fraction from the Bayesian IVIM model, in association with cellular proliferation, showed early sensitivity to good responders in NACT.

Clinical trial registration

https://clinicaltrials.gov/ct2/show/NCT03501394, identifier NCT03501394.
Vitamin E stabilizes iron and mitochondrial metabolism in pulmonary fibrosis
Authors: Chang Jing , Wang Jiahui , Luo Beibei , Li Weihao , Xiong Ziyue , Du Chaoqi , Wang Xue , Wang Yuejiao , Tian Jingya , Li Shuxin , Fang Yue , Li Longjie , Dong Jing , Tan Ke , Fan Yumei , Cao Pengxiu
Published: December 2023

Introduction: Pulmonary fibrosis (PF) is a fatal chronic lung disease that causes structural damage and decreased lung function and has a poor prognosis. Currently, there is no medicine that can truly cure PF. Vitamin E (VE) is a group of natural antioxidants with anticancer and antimutagenic properties. There have been a few reports about the attenuation of PF by VE in experimental animals, but the molecular mechanisms are not fully understood.

Methods: Bleomycin-induced PF (BLM-PF) mouse model, and cultured mouse primary lung fibroblasts and MLE 12 cells were utilized. Pathological examination of lung sections, immunoblotting, immunofluorescent staining, and real-time PCR were conducted in this study.

Results: We confirmed that VE significantly delayed the progression of BLM-PF and increased the survival rates of experimental mice with PF. VE suppressed the pathological activation and fibrotic differentiation of lung fibroblasts and epithelial-mesenchymal transition and alleviated the inflammatory response in BLM-induced fibrotic lungs and pulmonary epithelial cells in vitro. Importantly, VE reduced BLM-induced ferritin expression in fibrotic lungs, whereas VE did not exhibit iron chelation properties in fibroblasts or epithelial cells in vitro. Furthermore, VE protected against mitochondrial dysmorphology and normalized mitochondrial protein expression in BLM-PF lungs. Consistently, VE suppressed apoptosis in BLM-PF lungs and pulmonary epithelial cells in vitro.

Discussion: Collectively, VE markedly inhibited BLM-induced PF through a complex mechanism, including improving iron metabolism and mitochondrial structure and function, mitigating inflammation, and decreasing the fibrotic functions of fibroblasts and epithelial cells. Therefore, VE presents a highly potential therapeutic against PF due to its multiple protective effects with few side effects.
Preparation and investigation of a novel combination of Solanum nigrum-loaded, arabinoxylan-cross-linked β-cyclodextrin nanosponges for the treatment of cancer: in vitro, in vivo, and in silico evaluation
Authors: Shah Hamid Saeed , Zaib Sumera , Khan Imtiaz , Sliem Mahmoud A. , Alharbi Osama , Al-Ghorbani Mohammed , Jawad Zobia , Shahzadi Kiran , Awan Sajjad
Published: December 2023

Introduction: Cancer contributes to a high mortality rate worldwide spanning its diversity from genetics to resistant therapeutic response. To date emerging strategies to combat and manage cancer are particularly focused on the development of targeted therapies as conventional treatments account for the destruction of normal cells as well. In this regard, medicinal plant-based therapies are quite promising in imposing minimal side effects; however, limitations like poor bioavailability and stability of bioactive phytochemicals are associated with them. In parallel, nanotechnology provides nominal solution to deliver particular therapeutic agent without compromising its stability.

Methods: In this study, Solanum nigrum, an effective medicinal plant, loaded arabinoxylan cross-linked β-cyclodextrin nanosponges (SN-AXCDNS) were designed to evaluate antitumor activity against breast cancer. Therefore, SN-AXCDNS were prepared by using cross-linker melt method and characterized by physicochemical and pharmacological parameters.

Results: Hydrodynamic size, zeta potential and entrapment efficiency (EE%) were estimated as 226 ± 4 nm, −29.15 ± 5.71 mV and 93%, respectively. Surface morphology of nanocomposites showed spherical, smooth, and porous form. Antitumor pharmacological characterization showed that SN loaded nanosponge demonstrated higher cytotoxicity (22.67 ± 6.11 μg/mL), by inducing DNA damage as compared to void SN extract. Flow cytometry analysis reported that encapsulated extract promoted cell cycle arrest at sub-G1 (9.51%). Moreover, in vivo analysis demonstrates the reduction in tumor weight and 85% survival chances in nanosponge treated mice featuring its effectiveness. In addition, in silico analysis revealed that β-cyclodextrin potentially inhibits MELK in breast cancer cell lines (B.E = −10.1 Kcal/mol).

Conclusion: Therefore, findings of current study elucidated the therapeutic potential of β-cyclodextrin based nanosponges to be an alternative approach regarding the delivery and solubilization of antitumor drugs.
The mechanism and application of traditional Chinese medicine extracts in the treatment of lung cancer and other lung-related diseases
Authors: He Zhenglin , Wang Yihan , Han Liang , Hu Yue , Cong Xianling
Published: December 2023

Lung cancer stands as one of the most prevalent malignancies worldwide, bearing the highest morbidity and mortality rates among all malignant tumors. The treatment of lung cancer primarily encompasses surgical procedures, radiotherapy, and chemotherapy, which are fraught with significant side effects, unfavorable prognoses, and a heightened risk of metastasis and relapse. Although targeted therapy and immunotherapy have gradually gained prominence in lung cancer treatment, diversifying the array of available methods, the overall recovery and survival rates for lung cancer patients remain suboptimal. Presently, with a holistic approach and a focus on syndrome differentiation and treatment, Traditional Chinese Medicine (TCM) has emerged as a pivotal player in the prognosis of cancer patients. TCM possesses characteristics such as targeting multiple aspects, addressing a wide range of concerns, and minimizing toxic side effects. Research demonstrates that Traditional Chinese Medicine can significantly contribute to the treatment or serve as an adjunct to chemotherapy for lung cancer and other lung-related diseases. This is achieved through mechanisms like inhibiting tumor cell proliferation, inducing tumor cell apoptosis, suppressing tumor angiogenesis, influencing the cellular microenvironment, regulating immune system function, impacting signal transduction pathways, and reversing multidrug resistance in tumor cells. In this article, we offer an overview of the advancements in research concerning Traditional Chinese Medicine extracts for the treatment or adjunctive chemotherapy of lung cancer and other lung-related conditions. Furthermore, we delve into the challenges that Traditional Chinese Medicine extracts face in lung cancer treatment, laying the foundation for the development of diagnostic, prognostic, and therapeutic targets.
Inoculation with a microbial consortium increases soil microbial diversity and improves agronomic traits of tomato under water and nitrogen deficiency
Authors: Cirillo Valerio , Romano Ida , Woo Sheridan L. , Di Stasio Emilio , Lombardi Nadia , Comite Ernesto , Pepe Olimpia , Ventorino Valeria , Maggio Albino
Published: December 2023

Microbial-based biostimulants, functioning as biotic and abiotic stress protectants and growth enhancers, are becoming increasingly important in agriculture also in the context of climate change. The search for new products that can help reduce chemical inputs under a variety of field conditions is the new challenge. In this study, we tested whether the combination of two microbial growth enhancers with complementary modes of action, Azotobacter chroococcum 76A and Trichoderma afroharzianum T22, could facilitate tomato adaptation to a 30% reduction of optimal water and nitrogen requirements. The microbial inoculum increased tomato yield (+48.5%) under optimal water and nutrient conditions. In addition, the microbial application improved leaf water potential under stress conditions (+9.5%), decreased the overall leaf temperature (-4.6%), and increased shoot fresh weight (+15%), indicating that this consortium could act as a positive regulator of plant water relations under limited water and nitrogen availability. A significant increase in microbial populations in the rhizosphere with applications of A. chroococcum 76A and T. afroharzianum T22 under stress conditions, suggested that these inoculants could enhance soil microbial abundance, including the abundance of native beneficial microorganisms. Sampling time, limited water and nitrogen regimes and microbial inoculations all affected bacterial and fungal populations in the rhizospheric soil. Overall, these results indicated that the selected microbial consortium could function as plant growth enhancer and stress protectant, possibly by triggering adaptation mechanisms via functional changes in the soil microbial diversity and relative abundance.
Switching off automatic pilot to promote wellbeing and performance in the workplace: the role of mindfulness and basic psychological needs satisfaction
Authors: Guertin Rachel , Malo Marie , Gilbert Marie-Hélène
Published: December 2023

Introduction and method

Building on self-determination theory, this study aims to advance the happy-productive worker thesis by examining a sequential mediation linking trait mindfulness to task performance through basic psychological need satisfaction and psychological wellbeing at work. Whereas most of the papers published on the topic stem from USA and Europe, we tested our model in a Canadian sample of 283 French-speaking workers.

Results

Based on structural equation modeling, results show that the three need satisfactions at work mediate the relationship between trait mindfulness and psychological wellbeing at work. Rather than observing a sequential mediation, we find an indirect effect of trait mindfulness on task performance through the satisfaction for one of the basic psychological need (i.e., competence).

Discussion

The present research goes beyond previous studies by exploring a new pair of happy construct-productive criteria alongside an emergent intrapersonal factor contributing to this relationship.
Developing Climate Change and Health Impact Monitoring with eHealth at the South East Asia Community Observatory and Health and Demographic Surveillance Site, Malaysia (CHIMES)
Authors: Barteit Sandra , Colmar David , Nellis Syahrul , Thu Min , Watterson Jessica , Gouwanda Darwin , Bärnighausen Till , Su Tin Tin
Published: December 2023

Background

Malaysia is projected to experience an increase in heat, rainfall, rainfall variability, dry spells, thunderstorms, and high winds due to climate change. This may lead to a rise in heat-related mortality, reduced nutritional security, and potential migration due to uninhabitable land. Currently, there is limited data regarding the health implications of climate change on the Malaysian populace, which hinders informed decision-making and interventions.

Objective

This study aims to assess the feasibility and reliability of using sensor-based devices to enhance climate change and health research within the SEACO health and demographic surveillance site (HDSS) in Malaysia. We will particularly focus on the effects of climate-sensitive diseases, emphasizing lung conditions like chronic obstructive pulmonary disease (COPD) and asthma.

Methods

In our mixed-methods approach, 120 participants (>18 years) from the SEACO HDSS in Segamat, Malaysia, will be engaged over three cycles, each lasting 3 weeks. Participants will use wearables to monitor heart rate, activity, and sleep. Indoor sensors will measure temperature in indoor living spaces, while 3D-printed weather stations will track indoor temperature and humidity. In each cycle, a minimum of 10 participants at high risk for COPD or asthma will be identified. Through interviews and questionnaires, we will evaluate the devices’ reliability, the prevalence of climate-sensitive lung diseases, and their correlation with environmental factors, like heat and humidity.

Results

We anticipate that the sensor-based measurements will offer a comprehensive understanding of the interplay between climate-sensitive diseases and weather variables. The data is expected to reveal correlations between health impacts and weather exposures like heat. Participant feedback will offer perspectives on the usability and feasibility of these digital tools.

Conclusion

Our study within the SEACO HDSS in Malaysia will evaluate the potential of sensor-based digital technologies in monitoring the interplay between climate change and health, particularly for climate-sensitive diseases like COPD and asthma. The data generated will likely provide details on health profiles in relation to weather exposures. Feedback will indicate the acceptability of these tools for broader health surveillance. As climate change continues to impact global health, evaluating the potential of such digital technologies is crucial to understand its potential to inform policy and intervention strategies in vulnerable regions.
Sociodemographic factors affecting not receiving COVID-19 vaccine in Japan among people who originally intended to vaccinate: a prospective cohort study
Authors: Matsuyama Akiko , Mori Takahiro , Ogami Akira , Mafune Kosuke , Tateishi Seiichiro , Kuwamura Mami , Muramatsu Keiji , Fujino Yoshihisa , Mori Koji ,   CORoNaWork project
Published: December 2023

Objective

Vaccine hesitancy is a major issue for acquiring herd immunity. However, some individuals may go unvaccinated owing to inhibitory factors other than vaccine hesitancy. If there is even a small number of such people, support is needed for equitable vaccine distribution and acquiring herd immunity. We investigated sociodemographic factors that affected not undergoing COVID-19 vaccination in Japan among individuals who had strong intention to vaccinate before beginning the vaccination.

Methods

We conducted this prospective cohort study on workers aged 20–65 years from December 2020 (baseline), to December 2021 using a self-administered questionnaire survey. There were 27,036 participants at baseline and 18,560 at follow-up. We included 6,955 participants who answered yes to this question at baseline: “Would you like to receive a COVID-19 vaccine as soon as it becomes available?” We applied multilevel logistic regression analyses to examine the association between sociodemographic factors and being unvaccinated at follow-up.

Results

In all, 289 participants (4.2%) went unvaccinated. The odds ratios (ORs) for being unvaccinated were significantly higher for participants aged 30–39 and 40–49 than those aged 60–65 years. Being divorced, widowed, or single, having low income, and having COVID-19 infection experience also had higher ORs.

Discussion

We found that some participants who initially had strong intention to vaccinate may have gone unvaccinated owing to vaccine side effects and the financial impact of absenteeism due to side effects. It is necessary to provide information repeatedly about the need for vaccination as well as social support to ensure that those who intend to vaccinate are able to do so when aiming for acquiring herd immunity through vaccination against COVID-19 as well as other potential infection pandemics in the future.
The relation between barrier-free environment perception and campus commuting satisfaction
Authors: Li Jiang , Zhang Chuyu , Cai Xiaoxi , Peng You , Liu Shaobo , Lai Wenbo , Chang Yating , Liu Yudan , Yu Liang
Published: December 2023

Introduction

The COVID-19 pandemic, which began in the last quarter of 2019, has had a significant impact on urban transportation. With increasing demand for urban transport, the internal roads and public spaces of university campuses play an important role in facilitating commuting and communication between various functional zones. While considerable research has been conducted on route planning, pedestrian-vehicle segregation, and safety management in the internal transportation environment of university campuses, empirical investigations exploring barrier-free inclusive campus environment design and the subjective evaluation of road and public space users in the aftermath of the COVID-19 pandemic are lacking. Recent developments in travel behavior models and positive psychology have led to an increased focus on the correlation among subjective perceptions, attitudes, emotions, and commuting satisfaction in urban transportation and planning design.

Methods

To elucidate this relationship, a study was conducted on the new campus of Central South University in Changsha, Hunan Province, China. Using 312 valid samples, a structural equation model was constructed to analyse the relationship between commuting satisfaction and the barrier-free environment perception of university students regarding the internal transportation environment of the campus.

Results

The results revealed that individuals' instantaneous barrier-free environment perceptions and long-term established positive emotions had a significant positive effect on commuting satisfaction. Furthermore, positive emotions were found to mediate the relationship between commuting attitudes induced by COVID-19, barrier-free environment perceptions, and commuting satisfaction.

Discussion

The results of this study provide a theoretical basis for the necessity of accessibility design in the post-COVID era. In addition, this study considers the perspective of users to provide ideas for the planning and construction of barrier-free campus environments that are based on convenient and inclusive design.
Creating and manipulating 3D paths with mixed reality spatial interfaces
Authors: Hutton Pospick Courtney , Suma Rosenberg Evan
Published: December 2023

Mixed reality offers unique opportunities to situate complex tasks within spatial environments. One such task is the creation and manipulation of intricate, three-dimensional paths, which remains a crucial challenge in many fields, including animation, architecture, and robotics. This paper presents an investigation into the possibilities of spatially situated path creation using new virtual and augmented reality technologies and examines how these technologies can be leveraged to afford more intuitive and natural path creation. We present a formative study (n = 20) evaluating an initial path planning interface situated in the context of augmented reality and human-robot interaction. Based on the findings of this study, we detail the development of two novel techniques for spatially situated path planning and manipulation that afford intuitive, expressive path creation at varying scales. We describe a comprehensive user study (n = 36) investigating the effectiveness, learnability, and efficiency of both techniques when paired with a range of canonical placement strategies. The results of this study confirm the usability of these interaction metaphors and provide further insight into how spatial interaction can be discreetly leveraged to enable interaction at scale. Overall, this work contributes to the development of 3DUIs that expand the possibilities for situating path-driven tasks in spatial environments.
Advancing deep learning-based detection of floating litter using a novel open dataset
Authors: Jia Tianlong , Vallendar Andre Jehan , de Vries Rinze , Kapelan Zoran , Taormina Riccardo
Published: December 2023

Supervised Deep Learning (DL) methods have shown promise in monitoring the floating litter in rivers and urban canals but further advancements are hard to obtain due to the limited availability of relevant labeled data. To address this challenge, researchers often utilize techniques such as transfer learning (TL) and data augmentation (DA). However, there is no study currently reporting a rigorous evaluation of the effectiveness of these approaches for floating litter detection and their effects on the models' generalization capability. To overcome the problem of limited data availability, this work introduces the “TU Delft—Green Village” dataset, a novel labeled dataset of 9,473 camera and phone images of floating macroplastic litter and other litter items, captured using experiments in a drainage canal of TU Delft. We use the new dataset to conduct a thorough evaluation of the detection performance of five DL architectures for multi-class image classification. We focus the analysis on a systematic evaluation of the benefits of TL and DA on model performances. Moreover, we evaluate the generalization capability of these models for unseen litter items and new device settings, such as increasing the cameras' height and tilting them to 45°. The results obtained show that, for the specific problem of floating litter detection, fine-tuning all layers is more effective than the common approach of fine-tuning the classifier alone. Among the tested DA techniques, we find that simple image flipping boosts model accuracy the most, while other methods have little impact on the performance. The SqueezeNet and DenseNet121 architectures perform the best, achieving an overall accuracy of 89.6 and 91.7%, respectively. We also observe that both models retain good generalization capability which drops significantly only for the most complex scenario tested, but the overall accuracy raises significantly to around 75% when adding a limited amount of images to training data, combined with flipping augmentation. The detailed analyses conducted here and the released open source dataset offer valuable insights and serve as a precious resource for future research.
A comparative study in learning curves of laparoscopic lateral suspension vs. laparoscopic sacrocolpopexy: preliminary results
Authors: Malanowska-Jarema Ewelina , Osnytska Yana , Starczewski Andrzej , Balzarro Matteo , Rubilotta Emanuele
Published: December 2023

Background

Determination of the learning curve of new techniques is essential to improve safety and efficiency. Limited information is available regarding learning curves of different techniques in laparoscopic pelvic floor surgery.

Objective

The aim of this study was to compare the learning curve of two operative techniques, laparoscopic lateral suspension (LLS) and laparoscopic sacrocolpopexy (LSC).

Material and methods

We conducted a prospective study to assess the learning curve of LLS and LSC by implementing a structured urogynecologic surgical training program with the use of pelvic trainers for our urogynecology fellow. The fellow was an experienced urogynecologic surgeon, but was laparoscopic suturing and dissection naive at the beginning of the study. She was required to assist in 20 laparoscopic urogynecologic surgeries and undertake laparoscopic suturing and knot tying training with mesh positioning on a laparoscopic trainer for 4 h/week during the trial period. After the completion of this structured training program, the fellow performed LLS and LSC under the supervision of an experienced subspecialist as the primary surgeon. Linear regression analysis was used to compare the data of LLS and LSC learning curves. Subjective pre- and post-operative evaluation of pelvic organ prolapse (POP) and pelvic floor disorders was undertaken preoperatively and 12 months postoperatively using the PFDI-20-Quality of Life validated questionnaire. Follow-up was scheduled 12 months after the surgery and performed by a skilled urogynecologist. Objective cure was defined as Pelvic Organ Prolapse-Qualification (POP-Q) stage <II in any compartment.

Results

The mean operative times of laparoscopic sacrocolpopexy and lateral suspension were 168.26 and 160.33 min, respectively. According to linear regression analysis after 43 procedures, the learning curve for laparoscopic lateral suspension was shorter than for laparoscopic sacrocolpopexy (OPTime 134.69 min). In both groups, there was a significant reduction in bothersome POP symptoms (p ≤ 0.005). Bladder injuries in two cases and lumbar pain in one case were recorded during the study. Overall objective success at 12 months was 90.7% for LSC and 89.1% for LLS.

Conclusion

Laparoscopic lateral suspension could be an alternative to laparoscopic sacrocolpopexy in the treatment of POP with its good objective and subjective outcomes. Lateral suspension has a shorter learning curve, and it is technically less demanding than LSC. Procedure-dedicated training can accelerate the move from a novice to a master laparoscopic surgeon.
Combination of Organic and Inorganic Fertilizers to Counteract Climate Change Effects on Cultivation of Oilseed Flax (Linum usitatissimum L.) Using the APSIM Model in Arid and Semiarid Environments
Authors: Li Yue , Wu Bing , Gao Yuhong , Wu Ling , Zhao Xia , Wu Lili , Zhou Hui , Tang Jie
Published: December 2023

The impact of climate change on crop production is a major concern in drought-prone regions, which are experiencing increasingly severe drought conditions. The goal of this study was to use the Agricultural Production System Simulator (APSIM) model to simulate and predict flax yield and water balance, as well as to determine the optimal irrigation and fertilizer for flax production to counteract the effects of climate change under arid and semiarid conditions. The model was calibrated using field experimental data from 2019 to 2020 and evaluated using field experimental data from 2021 to 2022 with a combination of four irrigation treatments (full irrigation, 180 mm, deficit irrigation at vegetative and reproductive stage, no irrigation) and four fertilizer rates (no fertilizer, NPK, NPK + flax oil residue, NPK + farm manure) using a plot design for a total of 16 treatments. To determine the key irrigation and fertility periods and irrigation and fertilization amounts that affect flax yield to address climate change, a combination of four irrigation and six fertilizer rates and six irrigation stages were simulated. The results showed that the model successfully predicted flax yield (R2 = 0.98) and water-use efficiency (WUE) (R2 = 0.79). When compared to inorganic fertilization, the grain yield and WUE improved by 16.47% and 13.83%; replacing 50% of inorganic fertilizer with flax oil residue achieved the optimal results. The flax yield and WUE increased by 3.37% and 1.25% under full irrigation (180 mm) compared to irrigation of 120 mm with a not-very-significant difference. The positive effect of irrigation on soil water content (SWC) was highest during the budding stage, followed by the flowering stage, fruiting stage, and stemming stage. Therefore, in arid and semiarid areas with scarce water resources, irrigation at a 55% deficiency during the vegetative growth period of flax combined with the application of flax oil residue and NPK (1550 flax oil residue, 45 N, 50.2 P2O5, and 33.9 K2O kg ha−1) might be an effective adaptation strategy for improved future flax production. Our results can facilitate the development of sustainable agriculture practices that reduce water input and improve WUE to counteract climate change effects.
Effects of the Combined Application of Nitrogen and Selenium on Tea Quality and the Expression of Genes Involved in Nitrogen Uptake and Utilization in Tea Cultivar ‘Chuancha No.2’
Authors: Zhao Shenxin , Bai Yanling , Jin Zhen , Long Lu , Diao Wantian , Chen Wei , Tan Liqiang , Tang Qian , Tang Dandan
Published: December 2023

Nitrogen (N) and selenium (Se) are beneficial for tea growth and tea quality; however, it is unknown how the combined application of N and Se affects tea quality and N uptake and utilization in tea plants. In the present study, a hydroponic experiment with three N levels (0, 2 and 4.5 mmol/L) and three Se levels (0, 0.3 and 3 mg/L) was carried out with ‘Chuancha No.2’ as the material, and the contents of tea polyphenols, amino acids and caffeine as well as the expression levels of genes related to N uptake and utilization in tea plants were tracked. The findings reveal that the contents of tea polyphenols, AAs and caffeine in new shoots were the highest when supplied with 0.3 mg/L Se and 4.5 mmol/L N, while the contents of total N, AAs and tea polyphenols in mature leaves were the highest at the concentrations of 3 mg/L Se and 2 mmol/L N. Se supply (0.3 and 3 mg/L) induced an increase in amino acid and tea polyphenol contents in tea shoots under N deficiency conditions, whereas total N content, tea polyphenols and AAs in mature leaves and total N content in tea roots decreased significantly. When supplied with N (2 mmol/L and 4.5 mmol/L), the contents of tea polyphenols and caffeine in new shoots first increased and then decreased with the increase in Se concentration, while the total N content in mature leaves and roots increased. In leaves, CsAMT1.1, CsAMT1.2 and CsAMT3.1 had similar trends, and their expression levels were remarkably upregulated when supplied with 0.3 mg/L Se or 2 mmol/L N, respectively; the expression level of CsGS1.1 was significantly induced by N and Se, while CsGS1.2 and CsTS1 were mainly induced by N. In roots, CsAMT1.1 could play a major role in N uptake under the combined application of N and Se; CsGS1.2 expression was significantly induced compared to CsGS1.1 under the combined application of N and Se. This study explored the potential of the interaction of Se and N to promote tea quality and N uptake and utilization in tea plants.
The Impact of Fertilizer Type on Dry Matter, Nitrogen Partitioning, and Yield of Spring Maize with Film-Side Sowing
Authors: Zhang Tingting , Liu Jing , Zhang Haichao , Lian Ao , Gao Fei , Zhang Zhongdong , Guo Zhengyu
Published: December 2023

Dry matter (DM) and nitrogen (N) transport from nutritive organs to the grain is critical for cereal crop yield and protein content. There is limited research on the effects of slow-release or controlled-release fertilizers on dry matter and nitrogen partitioning in the nutrient organs of spring corn. A field trial was conducted in the National Corn Industry Technology System Xinzhou Comprehensive Experiment Station, China. The effects of different fertilizer management on yield, photosynthetic capacity, and nutrient partitioning of spring maize were studied. We modeled local farmers’ planting and management practices (T3). Based on T3, we added a slow-release compound fertilizer (T2), which does not require a follow-up fertilizer, and a controlled-release formulated fertilizer (T1), which is highly efficient and has low carbon emissions. The net photosynthetic rate (Pn), transpiration rate (E), stomatal conductance (Gs), and intercellular CO2 concentration (Ci) were 23%, 18.5%, 18%, 10.5% and 19%, 10.9%, 7%, and 5.5% higher in T1 compared to those of T3 and T2, respectively, at the ripening stage. The contribution of post-flowering DM transport to the kernel of T1 was 46% and 41.4% higher than that of T3 and T2, respectively. The nitrogen content of the kernel of T1 was 35.2% and 18.5% higher than that of T3 and T2, respectively. After a comprehensive analysis, T1 prolonged the photosynthetic effect through adequate nitrogen supply, provided nutrients to the kernel, promoted maize nitrogen uptake and utilization, and ultimately improved yield.
Physiological Response of the Target Stemborer Chilo suppressalis to Elevated CO2 as Reared with Transgenic Bt Rice during Different Plant Growth Stages
Authors: Liu Yanmin , Wang Yanhui , Li Sihan , Xie Boxuan , Chen Geng , Chen Fajun
Published: December 2023

Transgenic Bt rice (abbr. Bt rice) has provided a powerful tactics to control the striped stemborer Chilo suppressalis as one key lepidopteran pest in the paddyfields of China. Globally rising carbon dioxide (i.e., CO2) concentration has been predicted to affect the Cry protein contents in plant tissues of Bt rice and thus might affect its control efficiency to target insect pests. To reveal the resistance ability and the corresponding mechanism of C. suppressalis to Bt rice during different growth stage under elevated CO2 (eCO2), we carried out this experiment to measure the Bt toxin contents in Bt rice stems grown under ambient CO2 (aCO2) (400 ppm) and eCO2 (800 ppm) at seedling, tillering and heading stages, and to observe the larval mortality and bioassay the activity of midgut protease and the expression levels of Bt-toxin-receptor genes, aminopeptidases (APNs) in C. suppressalis larvae. Compared with aCO2, eCO2 increased the Bt-toxin content of Bt rice at seedling stage (+6.66%), and decreased that at heading stages (−13.99%), and significantly reduced the Bt-toxin content at tillering stage (−15.21%). And the larval mortality of C. suppressalis was lower as reared with Bt rice stems during tillering stage grown under eCO2 in contrast to aCO2. In addition, eCO2 significantly increased the activity of total protease, tryptase-like enzyme and aminopeptidase of C. suppressalis larvae fed on Bt rice during seedling stage, and significantly reduced the activity of tryptase-like enzyme and aminopeptidase of C. suppressails larvae fed on Bt rice during tillering and heading stages respectively. Moreover, eCO2 significantly increased the expression level of APN1 and APN5 of C. suppressails larvae fed on Bt rice during seedling stage, and significantly reduced the expression level of APN5 of C. suppressalis larvae fed on Bt rice during tillering and heading stages respectively. In summary, the control efficiency of Bt rice to target insect pests under eCO2 showed a downward trend during tillering and heading stages, and especially during tillering stage.
Imitation of Novel Intransitive Body Actions in a Beluga Whale (Delphinapterus leucas): A “Do as Other Does” Study
Authors: Zamorano-Abramson José , Hernández-Lloreda María Victoria
Published: December 2023

Cetaceans are well known for their unique behavioral habits, such as calls and tactics. The possibility that these are acquired through social learning continues to be explored. This study investigates the ability of a young beluga whale to imitate novel behaviors. Using a do-as-other-does paradigm, the subject observed the performance of a conspecific demonstrator involving familiar and novel behaviors. The subject: (1) learned a specific ‘copy’ command; (2) copied 100% of the demonstrator’s familiar behaviors and accurately reproduced two out of three novel actions; (3) achieved full matches on the first trial for a subset of familiar behaviors; and (4) demonstrated proficiency in coping with each familiar behavior as well as the two novel behaviors. This study provides the first experimental evidence of a beluga whale’s ability to imitate novel intransitive (non-object-oriented) body movements on command. These results contribute to our understanding of the remarkable ability of cetaceans, including dolphins, orcas, and now beluga whales, to engage in multimodal imitation involving sounds and movements. This ability, rarely documented in non-human animals, has significant implications for the development of survival strategies, such as the acquisition of knowledge about natal philopatry, migration routes, and traditional feeding areas, among these marine mammals.
Protective Role of Bergamot Polyphenolic Fraction (BPF) against Deltamethrin Toxicity in Honeybees (Apis mellifera)
Authors: Bava Roberto , Castagna Fabio , Ruga Stefano , Caminiti Rosamaria , Nucera Saverio , Bulotta Rosa Maria , Naccari Clara , Britti Domenico , Mollace Vincenzo , Palma Ernesto
Published: December 2023

Pesticide-induced poisoning phenomena are a serious problem for beekeeping and can cause large losses of honeybee populations due to acute and sub-acute poisoning. The reduced responsiveness of honeybees to the damage caused by pesticides used in agriculture can be traced back to a general qualitative and quantitative impoverishment of the nectar resources of terrestrial ecosystems. Malnutrition is associated with a decline in the functionality of the immune system and the systems that are delegated to the detoxification of the organism. This research aimed to verify whether bergamot polyphenolic extract (BPF) could have protective effects against poisoning by the pyrethroid pesticide deltamethrin. The studies were conducted with caged honeybees under controlled conditions. Sub-lethal doses of pesticides and related treatments for BPF were administered. At a dose of 21.6 mg/L, deltamethrin caused mortality in all treated subjects (20 caged honeybees) after one day of administration. The groups where BPF (1 mg/kg) was added to the toxic solution recorded the survival of honeybees by up to three days. Comparing the honeybees of the groups in which the BPF-deltamethrin association was added to the normal diet (sugar solution) with those in which deltamethrin alone was added to the normal diet, the BPF group had a statistically significant reduction in the honeybee mortality rate (p ≤ 0.05) and a greater consumption of food. Therefore, it can be argued that the inclusion of BPF and its constituent antioxidants in the honeybee diet reduces toxicity and oxidative stress caused by oral intake of deltamethrin. Furthermore, it can be argued that BPF administration could compensate for metabolic energy deficits often induced by the effects of malnutrition caused by environmental degradation and standard beekeeping practices.