bluuebunny/crossref_metadata_2025 huggingface dataset:
State Formation, Visual Technology and Spectatorship: Visions of Modernity in Brazil and Argentina
Authors: Andermann Jens
Published: January 2011

How can we conceive of the relation between technologies of image-making and the formations of political power, without reducing the former to merely superstructural effects of a pre-existing ideology or deducing the latter from the functional determination inherent in technical apparatuses? In this article, I revisit the notion of the state as a visual form I proposed in an earlier work, arguing that in order to understand the articulation between politics and visuality in modernity we need to pay attention to the performance of showing and seeing that mediates between the spectacle and spectatorship. To grasp the way in which historical change (political and technological) impacts on this constellation, in particular in the transition from photographic to cinematic regimes of visuality between the late 19th and early 20th century, I take these questions through two rather different ‘case studies’: photographer Juan Gutiérrez’s images of Brazilian state rituals in the mid-1890s and Jorge Luis Borges’s short story ‘The Aleph’ of 1949. Whereas Gutiérrez’s photographic series, I argue, announces the cinema and its ways of mobilizing actors and spectators alike, as the limit of a 19th-century visuality primed on the stability and self-enclosedness of viewers and objects, Borges’s story retrospectively enacts the transition from photographic to cinematic seeing in an intratextual battle of acts of transcription from the impossible object at the centre of the plot, which grants infinite, universal visibility to the one who beholds it. Reading the two together, or against one another, then, allows us to see the dimension of transience undercutting the apparent solidity and timelessness with which scopic regimes promise us access to the real.
Getting Rid of the Distinction between the Aesthetic and the Political
Authors: Azoulay Ariella
Published: January 2011

The point of departure of Berger and Mohr’s Another Way of Telling (1982) is what they call the discovery that ‘photographs did not work as we had been taught’. Since their book was written, the same feeling of ‘discovery’ has been expressed in other writings on photography. Often, these ‘discoveries’ have been linked with the way ‘ordinary’ people have been using photography. This paper addresses this recurrence and asks what are the discursive conditions under which this understanding of photography has been perceived as a ‘discovery’ whenever it has surfaced in the last 30 years. The paper analyzes the conceptual grid within the hegemonic discourse on photography that has contributed enormously to the marginalization of this new understanding of photography — the common opposition between the ‘aesthetic’ and the ‘political’, and accordingly between two seemingly contradictory judgments: ‘this is too political’; ‘this is too aesthetic’. These judgments, applied frequently to photographs taken in zones of ‘regime-made disaster’, usually differ and sometimes completely prevent the possible encounter with the photographed people who, through the photograph, are co-present with the spectators in the event of viewing the photograph.
Reconstruction of the Lateral Ankle Ligament With a Long Extensor Tendon Graft of the Fourth Toe
Authors: Ahn Jae Hoon , Choy Won-Sik , Kim Ha-Yong
Published: January 2011

Background: The treatment of lateral ankle instability is challenging when the remaining ligamentous tissue is insufficient. Anatomic reconstruction with a tendon graft is a good option that can produce a stable ankle and avoid the complications of a nonanatomic tenodesis procedure.

Hypothesis: A new technique for anatomically reconstructing the lateral ligaments of the ankle using an extensor digitorum longus tendon graft of the fourth toe will be effective for treating lateral ankle instability with chronic ligamentous insufficiency.

Study Design: Case series; Level of evidence, 4.

Methods: Twenty-four patients were treated with anatomic reconstruction of the ligaments using the long extensor tendon of the fourth toe. The mean age was 35.7 years (range, 16-53 years). The minimum follow-up was 24 months (range, 24-57 months; mean, 37 months). There were 17 cases of chronic ligamentous insufficiency, 3 failed Brostrom operations, and 4 others. Preoperative and postoperative Karlsson scales were used to analyze the functional results. The anterior displacement and the talar tilt angle on standard stress radiography of the talocrural joint were measured preoperatively and at the time of last follow-up for comparison.

Results: The results on the Karlsson scale increased from 48.0 ± 4.2 points preoperatively to 92.2 ± 3.8 points at the latest follow-up ( P < .01). Radiographically, the mean anterior displacement was 6.7 ± 1.2 mm before operation and 3.4 ± 0.6 mm at the latest follow-up ( P < .01). The mean talar tilt angle was 12.3° ± 1.1° before the operation and 4.3° ± 0.8° at the latest follow-up ( P < .01).

Conclusion: Anatomic reconstruction of the lateral ankle ligaments using the long extensor tendon of the fourth toe appears to be an effective surgical option for chronic insufficiency of the lateral ankle ligament.
Percutaneous Internal Fixation of Proximal Fifth Metatarsal Jones Fractures (Zones II and III) With Charlotte Carolina Screw and Bone Marrow Aspirate Concentrate
Authors: Murawski Christopher D. , Kennedy John G.
Published: January 2011

Background: Internal fixation is a popular first-line treatment method for proximal fifth metatarsal Jones fractures in athletes; however, nonunions and screw breakage can occur, in part because of nonspecific fixation hardware and poor blood supply.

Purpose: To report the results from 26 patients who underwent percutaneous internal fixation with a specialized screw system of a proximal fifth metatarsal Jones fracture (zones II and III) and bone marrow aspirate concentrate.

Study Design: Case series; Level of evidence, 4.

Methods: Percutaneous internal fixation for a proximal fifth metatarsal Jones fracture (zones II and III) was performed on 26 athletic patients (mean age, 27.47 years; range, 18-47). All patients were competing at some level of sport and were assessed preoperatively and postoperatively using the Foot and Ankle Outcome Score and SF-12 outcome scores. The mean follow-up time was 20.62 months (range, 12-28). Of the 26 fractures, 17 were traditional zone II Jones fractures, and the remaining 9 were zone III proximal diaphyseal fractures.

Results: The mean Foot and Ankle Outcome Score significantly increased, from 51.15 points preoperatively (range, 14-69) to 90.91 at final follow-up (range, 71-100; P < .01). The mean physical component of the SF-12 score significantly improved, from 25.69 points preoperatively (range, 6-39) to 54.62 at final follow-up (range, 32-62; P < .01). The mean mental component of the SF-12 score also significantly improved, from 28.20 points preoperatively (range, 14-45) to 58.41 at final follow-up (range, 36-67; P < .01). The mean time to fracture healing on standard radiographs was 5 weeks after surgery (range, 4-24). Two patients did not return to their previous levels of sporting activity. One patient experienced a delayed union, and 1 healed but later refractured.

Conclusion: Percutaneous internal fixation of proximal fifth metatarsal Jones fractures, with a Charlotte Carolina screw and bone marrow aspirate concentrate, provides more predictable results while permitting athletes a return to sport at their previous levels of competition, with few complications.
Gelastic Seizures in Tuberous Sclerosis Complex: Case Report and Literature Review
Authors: Cook Tara , Joshi Charuta
Published: January 2011

Gelastic seizures are typically associated with hypothalamic hamartoma. Given the rarity of gelastic seizures, pathways for the motor and emotional aspects of laughter have been hypothesized but remain unclear. The authors perform a literature review to discuss what is known about these pathways. They also report a child who presented with tuberous sclerosis complex initially without cutaneous stigmata, who later developed gelastic seizures. Only 2 case reports of patients with tuberous sclerosis complex who subsequently developed gelastic epilepsy have previously been reported. In discussing his case, the authors postulate additional etiologies for gelastic seizures.
Why Can Seizures Remain Intractable? Clinical Vignettes From the Life Experience of a Pediatric Epileptologist
Authors: Lerman Pinchas , Sagie Shira , Lerman-Sagie Tally
Published: January 2011

Most childhood seizures can be controlled by the appropriate antiepileptic drugs. When seizures remain intractable in a normally developing child with an intact neurologic examination, it is usually possible to identify a clear reason, and the physician, like a detective, needs to investigate and reveal it. In this article we will describe cases that were encountered during a lifetime at a pediatric epilepsy clinic, which will illustrate the different reasons seizures remain intractable in patients who do not have structural abnormalities or resistant epileptic syndromes.
Critical Psychology and Career Development
Authors: Prilleltensky Isaac , Stead Graham B.
Published: January 2011

Adjusting to the world of work or challenging it is a dilemma that career counselors and helpers encounter daily. Counselors and clients may opt for one of the following choices: (a) adjust to, and challenge the system, at the same time, (b) adjust to the system but do not challenge it, (c) challenge the system but do not adjust to it, and (d) neither adjust to the system nor challenge it. These four scenarios are analyzed from the perspective of critical psychology and psychopolitical validity. A model depicting the various consequences of each choice for power relations, social justice, and the well-being of people, organizations, communities, and the environment is introduced. The model can guide practitioners in discerning the consequences of their actions and those of their clients.
A Case Study of Issues Concerning Professional Development for Rural Instrumental Music Teachers
Authors: Burkett Eugenie I.
Published: January 2011

Current legislation focusing on the professional development (PD) of teachers has come under closer scrutiny since the advent of the No Child Left Behind Act of 2001. The purpose of the present study was to investigate the effects of music specific PD activities provided as part of a community symphony orchestra’s educational outreach project on rural instrumental music teachers. Rural music teachers face unique challenges of time, place, and distance. The problem was to determine the extent to which rural instrumental music teachers’ attitudes, teaching strategies, and musical skills are affected through onsite music-oriented PD activities. PD activities designed specifically for instrumental music teachers appeared to stimulate and improve teachers’ personal self-development of music and teaching skills. Data indicate that PD must be oriented toward relevant and useful topics and experiences that spark an inquisitiveness and continuing curiosity of learning and self-development in teachers, and to counteract the complacency that may occur from being in a fixed, isolated career path.
Parenting training in the community: linking process to outcome
Authors: Kilroy Sarah , Sharry John , Flood Catriona , Guerin Suzanne
Published: January 2011

This pilot study examines the effectiveness of the Parents Together Community Coursei (a six week preventative version of the Parents Plus Early Years Programme) in reducing parent-reported behaviour problems in pre-school and school aged children. It also investigates if there is an association between process ratings on a weekly session rating form (WSRF) and client outcome. Thirty-one parents who completed the course filled out pre and post outcome measures (namely the Strengths and Difficulties Questionnaire (SDQ) and a specially designed Client defined Problem and Goals form (CPG)), and a process measure during the course of the group. It was found that 45% of children in the community sample had behavioural problems in the borderline or clinical range, and significant reductions in these problem behaviours and gains towards parent-defined goals were observed following the course. Results also showed a number of correlations between high ratings on the WSRF and positive outcome as measured by the CPG and SDQ indicating a possible link between this process measure and outcomes. This highlights the importance of early community interventions in dealing with childhood behaviour problems and the possible utility of a process measure for identifying contributing factors to change.
Personality subtypes in adolescents with panic disorder
Authors: Powers Abigail D. , Westen Drew
Published: January 2011

This study examined personality subtypes of adolescents diagnosed with Panic Disorder (PD). As part of an NIMH-funded study of adolescent personality and its relation to psychopathology, randomly selected experienced licensed psychologists and psychiatrists used a Q-sort instrument to describe adolescents in their care, of whom 57 had been diagnosed with PD. Q-factor analysis yielded three personality subtypes: High Functioning/Dysphoric, Emotionally Dysregulated, and Avoidant. The subtypes differed on axis I and II pathology, adaptive functioning, and developmental and family history variables. Personality constellations showed substantial incremental validity in predicting adaptive functioning above and beyond DSM-IV axis I diagnoses. The results resemble subtypes recently identified in adults and suggest that adolescents who present with panic symptoms are a heterogeneous group, whose personality needs to be considered in understanding and helping them clinically.
Changing images of the USA in German media discourse during four American presidencies
Authors: Pettersson Lucas
Published: January 2011

•This article presents a study of how images of the United States have changed in German media discourse since the end of the Cold War. Two leading German news papers, Frankfurter Allgemeine Zeitung and Süddeutsche Zeitung, have been analysed during four time periods — from 1984 to 2009 — covering four American presidencies. The results show that the image of the USA was far more critical in 2004, during the Bush era than during the other presidencies, where positive and trustful images had a more prominent place in the discourse. Even anti-American images were found. However, the critical images were, in general, more focused on what the USA does, not what it is — even during the Bush era. Furthermore, the relationship between the USA and Germany was portrayed as being close and friendly — like a father—son relationship — with the exception of 2004, when relations were presented as somewhat strained. •
The VA Hypertension Primary Care Longitudinal Cohort: Electronic medical records in the post-genomic era
Authors: Salem Rany M. , Pandey Braj , Richard Erin , Fung Maple M. , Garcia Erin P. , Brophy Victoria H. , Schork Nicholas J. , O'Connor Daniel T. , Bhatnagar Vibha
Published: January 2011

The Veterans Affairs Hypertension Primary Care Longitudinal Cohort (VAHC) was initiated in 2003 as a pilot study designed to link the VA electronic medical record system with individual genetic data. Between June 2003 and December 2004, 1,527 hypertensive participants were recruited. Protected health information (PHI) was extracted from the regional VA data warehouse. Differences between the clinic and mail recruits suggested that clinic recruitment resulted in an over-sampling of African Americans. A review of medical records in a random sample of study participants confirmed that the data warehouse accurately captured most selected diagnoses. Genomic DNA was acquired non-invasively from buccal cells in mouthwash; ~ 96.5 per cent of samples contained DNA suitable for genotyping, with an average DNA yield of 5.02 ± 0.12 micrograms, enough for several thousand genotypes. The coupling of detailed medical databases with genetic information has the potential to facilitate the genetic study of hypertension and other complex diseases.
International education: The International Baccalaureate, Montessori and global citizenship
Authors: Brunold-Conesa Cynthia
Published: January 2011

The International Baccalaureate (IB) programs and Montessori education both claim to promote values associated with global citizenship in order to help prepare students for new challenges presented by an increasingly globalized world. While the IB’s secondary programs are widespread in international schools, Montessori programs at that level are comparatively few. This article compares and contrasts IB and Montessori secondary programs with respect to the promotion of global citizenship, and explores the scarcity of secondary Montessori programs in general and in the international schools community in particular.
Interview with Jon Lewis, Corvallis, Oregon, September 21, 2008
Authors: King Noel
Published: January 2011

In this interview Jon Lewis reflects on his period as editor of Cinema journal and discusses changes in the historical-critical emphases at play in the field of film and media studies as it begins to engage more directly with the claims of television studies and the emerging field of new media studies. He further discusses the shifts he has observed in film and media studies as an area of academic publication, over the course of his academic career, noting the impact of the current context of more limited or competitive publication possibilities on younger academics hoping for a career in the profession. Finally, he discusses his own recent research and publications, and speculates on two further, ongoing areas of research: his work on HUAC, and even more specifically his work on the memoirs of HUAC survivors; and his involvement with research into the place of soccer in US sporting and cultural life.
‘They Didn’t Consider Me and No-one Even Took Me into Account’: Female School Principals in the Arab Education System in Israel
Authors: Shapira Tamar , Arar Khalid , Azaiza Faisal
Published: January 2011

The study of women’s management and leadership in education has become a central research topic and the copious work published in many countries encompasses various issues relating to gender and educational leadership. The study of female school principals from the Arab minority in Israel has only recently begun. This is a minority that lives mostly in separate settlements, distinguished from the majority Jewish population by their lifestyle and culture, in a society that can be described as developing. In-depth interviews were conducted with the seven female school principals, from different socio-cultural backgrounds, who had successfully climbed the professional ladder to senior positions in the Arab education system in Israel. Data-analysis addressed three areas: biographical background; the social and political aspects of the women’s nomination to principalship; and the social and professional acceptance of the women as principals. Findings indicated that women principals contribute significantly to the development of Arab schools. As women in senior roles, the majority faces resistance; a change of societal norms and willingness to accept women’s leadership would enable many more women to fill public roles and to contribute to their society’s progress.
Young people and police series: A multicultural television audience study
Authors: De Bruin Joost
Published: January 2011

Police series are a main genre of popular television drama in the Netherlands. This article analyses interviews with young people from a range of ethnic backgrounds about the Dutch police series Baantjer and Spangen. Very little audience research has been carried out internationally into crime drama and this study aims to develop insight into how viewers watch and interpret police series. The informants interpreted Dutch police series in two different ways. First, they watched police series with friends or family to play the game of 'whodunit’, drawing on the hermeneutic narrative code. Second, they used the cultural narrative code to talk about experiences regarding crime, the police, racism and cultural difference at school and in the city. Due to their diverse representations Dutch police series offer viewers opportunities to discuss salient themes within Dutch multicultural society.
The pursuit of excellence: engaging the community in participatory health research
Authors: Ramsden Vivian R. , McKay Shari , Crowe Jackie
Published: January 2011

Community-based participatory research approaches are designed to improve health and well-being in communities and to minimize health disparities in general. It is this partnership approach to research that equitably involves community members, organizational representatives and researchers in all aspects of the research process and in which all partners contribute expertise, decision-making and ownership. Further to this, community-based participatory research is utilized to study and address community-identified issues through a collaborative and empowering action-oriented process that builds on the strengths of the community. The results of this research endeavour highlight the need for integrating community-based participatory research, primary health care and social accountability in the pursuit of excellence. The process and the results/findings provide ways that the community are able to enhance their health and wellness, increase capacity and be empowered to direct their education, research and service activities towards addressing and meeting the health priorities of the community.
Constructing an action agenda for community empowerment at the 7th Global Conference on Health Promotion in Nairobi
Authors: Fawcett Stephen , Abeykoon Palitha , Arora Monika , Dobe Madhumita , Galloway-Gilliam Lark , Liburd Leandris , Munodawafa Davison
Published: January 2011

This report describes an action agenda for community empowerment developed by participants at the 7th Global Conference on Health Promotion in Nairobi. It outlines gaps and barriers in enabling community empowerment; including those related to institutional capacity, institutional relationships to the community, and institutional responses to the social structure of the community. The report features nine recommended actions to enhance community control of health promotion initiatives, develop sustainable resources for community health efforts, and support implementation and build evidence for health promotion effectiveness. Implementing these recommended actions can enhance community empowerment and help close the implementation gap in health promotion.
Preserving idealism in global health promotion
Authors: Franco-Paredes Carlos , Zeuli Julia , Hernández-Ramos Isabel , Santos-Preciado Jose I.
Published: January 2011

If the field of global health is to evolve in the second decade of the new millennium, we need to revive the idealistic spirit and by using the lens of health equity work toward improved health status around the world. Morality and empathy are considered by-products of our evolutionary history as a human species. Idealism may be a trait that we may choose to preserve in our modern evolutionary history.
Mediatization and Media Interventionism: A Comparative Analysis of Sweden and the United States
Authors: Strömbäck Jesper , Dimitrova Daniela V.
Published: January 2011

Although mediatization as a term is commonly used in the academic literature, it is rarely defined well and there are almost no studies that explicitly seek to investigate the mediatization of politics. Drawing on the literature on mediatization, media interventionism, political news journalism and related areas, the purpose of this article is to develop indicators of the degree to which news content is mediatized, and test these in a comparative content analysis of how Swedish and US television news covered the 2006 Swedish and 2008 US election campaigns. The results show that election news on US television is more mediatized than that on Swedish television, as expected. However, few differences were found across commercial and public service television news within Sweden. The study also suggests that the mediatization of news content may be moderated by national journalism cultures, political news cultures and political communication cultures.
The Tainted Hero: Frames of Domestication in Norwegian Press Representation of the Bali Climate Summit
Authors: Eide Elisabeth , Ytterstad Andreas
Published: January 2011

This article presents an analysis of two major Norwegian newspapers’ coverage of a major transnational media event—the Bali Climate Summit in December 2007. Climate Summits are seen as ample opportunities to study journalism at the global level and simultaneously the relation between global and local perspectives. It demonstrates how main national actors within the political field exercise their hegemony toward the press and that the Norwegian leaders in Bali are partly framed as global heroes. But it furthermore reveals how a critical scrutiny of Norway’s role as a major oil polluter emerges in the press in opposition to the hero framing. Thus, a distinction between different modes of journalistic domestication is made, which invites more critical scrutiny of Climate Change actors both within the confines of the nation-state and more globally. The investigation is based on textual analysis as well as framing theory—and on perspectives of hegemony and “good sense” within the journalistic field.
The integrin LFA-1 signals through ZAP-70 to regulate expression of high-affinity LFA-1 on T lymphocytes
Authors: Evans Rachel , Lellouch Annemarie C. , Svensson Lena , McDowall Alison , Hogg Nancy
Published: January 2011

The integrin lymphocyte function-associated antigen 1 (LFA-1) controls many functions of T lymphocytes and is particularly essential during lymphocyte migration from blood into tissues. LFA-1 is considered to initiate “outside-in” signaling when bound to ligand intercellular adhesion molecule 1 (ICAM-1), but little is known about the proteins involved or where in the cell such LFA-1–mediated signaling might be operating. Here we show that LFA-1 is constitutively associated with the protein tyrosine kinases Lck and zeta chain–associated protein of 70 kDa (ZAP-70). When LFA-1 binds ICAM-1, both kinases become phosphorylated and the consequence of kinase activation is the conversion of intermediate- to high-affinity LFA-1 and an increase in close contact with ICAM-1. In the polarized T lymphocyte, phospho-ZAP-70 is concentrated within a region of high-affinity LFA-1 that includes talin and encompasses the lamella/lamellipodial interface as well as further back in the cell. Deficiency of ZAP-70 through inhibition or knockdown in T lymphocytes decreases the speed of migration on ICAM-1, as well as reducing firm adhesion under shear-flow conditions. Through its control of high-affinity LFA-1, the LFA-1/Lck/ZAP-70 complex is in position to initiate the rapid adhesion strengthening and migration necessary for T-lymphocyte responses when stimulated vasculature is encountered at sites of infection or injury.
Pathways to HIV risk and vulnerability among lesbian, gay, bisexual, and transgendered methamphetamine users: a multi-cohort gender-based analysis
Authors: Marshall Brandon DL , Wood Evan , Shoveller Jean A , Patterson Thomas L , Montaner Julio SG , Kerr Thomas
Published: January 2011

Background

Methamphetamine (MA) use continues to be a major public health concern in many urban settings. We sought to assess potential relationships between MA use and individual, social, and structural HIV vulnerabilities among sexual minority (lesbian, gay, bisexual or transgendered) drug users.

Methods

Beginning in 2005 and ending in 2008, 2109 drug users were enroled into one of three cohort studies in Vancouver, Canada. We analysed longitudinal data from all self-identified sexual minority participants (n = 248). Logistic regression using generalized estimating equations (GEE) was used to examine the independent correlates of MA use over time. All analyses were stratified by biological sex at birth.

Results

At baseline, 104 (7.5%) males and 144 (20.4%) females reported sexual minority status, among whom 64 (62.1%) and 58 (40.3%) reported MA use in the past six months, respectively. Compared to heterosexual participants, sexual minority males (odds ratio [OR] = 3.74, p < 0.001) and females (OR = 1.80, p = 0.003) were more likely to report recent MA use. In multivariate analysis, MA use among sexual minority males was associated with younger age (adjusted odds ratio [AOR] = 0.93 per year older, p = 0.011), Aboriginal ancestry (AOR = 2.59, p = 0.019), injection drug use (AOR = 3.98, p < 0.001), having a legal order or area restriction (i.e., "no-go zone") impact access to services or influence where drugs are used or purchased (AOR = 4.18, p = 0.008), unprotected intercourse (AOR = 1.62, p = 0.048), and increased depressive symptoms (AOR = 1.67, p = 0.044). Among females, MA use was associated with injection drug use (AOR = 2.49, p = 0.002), Downtown South residency (i.e., an area known for drug use) (AOR = 1.60, p = 0.047), and unprotected intercourse with sex trade clients (AOR = 2.62, p = 0.027).

Conclusions

Methamphetamine use was more prevalent among sexual minority males and females and was associated with different sets of HIV risks and vulnerabilities. Our findings suggest that interventions addressing MA-related harms may need to be informed by more nuanced understandings of the intersection between drug use patterns, social and structural HIV vulnerabilities, and gender/sexual identities. In particular, MA-focused prevention and treatment programs tailored to disenfranchised male and female sexual minority youth are recommended.
Estimated incidence of cardiovascular complications related to type 2 diabetes in Mexico using the UKPDS outcome model and a population-based survey
Authors: Reynoso-Noverón Nancy , Mehta Roopa , Almeda-Valdes Paloma , Rojas-Martinez Rosalba , Villalpando Salvador , Hernández-Ávila Mauricio , Aguilar-Salinas Carlos A
Published: January 2011

Background

To estimate the incidence of complications, life expectancy and diabetes related mortality in the Mexican diabetic population over the next two decades using data from a nation-wide, population based survey and the United Kingdom Prospective Diabetes Study (UKPDS) outcome model

Methods

The cohort included all patients with type 2 diabetes evaluated during the National Health and Nutrition Survey (ENSANut) 2006. ENSANut is a probabilistic multistage stratified survey whose aim was to measure the prevalence of chronic diseases. A total of 47,152 households were visited. Results are shown stratified by gender, time since diagnosis (> or ≤ to 10 years) and age at the time of diagnosis (> or ≤ 40 years).

Results

The prevalence of diabetes in our cohort was 14.4%. The predicted 20 year-incidence for chronic complications per 1000 individuals are: ischemic heart disease 112, myocardial infarction 260, heart failure 113, stroke 101, and amputation 62. Furthermore, 539 per 1000 patients will have a diabetes-related premature death. The average life expectancy for the diabetic population is 10.9 years (95%CI 10.7-11.2); this decreases to 8.3 years after adjusting for quality of life (CI95% 8.1-8.5). Male sex and cases diagnosed after age 40 have the highest risk for developing at least one major complication during the next 20 years.

Conclusions

Based on the current clinical profile of Mexican patients with diabetes, the burden of disease related complications will be tremendous over the next two decades.
Nonparametric intensity bounds for the delineation of spatial clusters
Authors: Oliveira Fernando LP , Duczmal Luiz H , Cançado André LF , Tavares Ricardo
Published: January 2011

Background

There is considerable uncertainty in the disease rate estimation for aggregated area maps, especially for small population areas. As a consequence the delineation of local clustering is subject to substantial variation. Consider the most likely disease cluster produced by any given method, like SaTScan, for the detection and inference of spatial clusters in a map divided into areas; if this cluster is found to be statistically significant, what could be said of the external areas adjacent to the cluster? Do we have enough information to exclude them from a health program of prevention? Do all the areas inside the cluster have the same importance from a practitioner perspective?

Results

We propose a method to measure the plausibility of each area being part of a possible localized anomaly in the map. In this work we assess the problem of finding error bounds for the delineation of spatial clusters in maps of areas with known populations and observed number of cases. A given map with the vector of real data (the number of observed cases for each area) shall be considered as just one of the possible realizations of the random variable vector with an unknown expected number of cases. The method is tested in numerical simulations and applied for three different real data maps for sharply and diffusely delineated clusters. The intensity bounds found by the method reflect the degree of geographic focus of the detected clusters.

Conclusions

Our technique is able to delineate irregularly shaped and multiple clusters, making use of simple tools like the circular scan. Intensity bounds for the delineation of spatial clusters are obtained and indicate the plausibility of each area belonging to the real cluster. This tool employs simple mathematical concepts and interpreting the intensity function is very intuitive in terms of the importance of each area in delineating the possible anomalies of the map of rates. The Monte Carlo simulation requires an effort similar to the circular scan algorithm, and therefore it is quite fast. We hope that this tool should be useful in public health decision making of which areas should be prioritized.
Pepper leaf curl Lahore virus requires the DNA B component of Tomato leaf curl New Delhi virus to cause leaf curl symptoms
Authors: Shafiq Muhammad , Asad Shaheen , Zafar Yusuf , Briddon Rob W , Mansoor Shahid
Published: January 2011

Background

Begomoviruses are whitefly-transmitted geminiviruses with genomes that consist of either two components (known as DNA A and DNA B) or a single component (homologous to the DNA A component of bipartite begomoviruses). Monopartite begomoviruses are often associated with a symptom-modulating DNA satellite (collectively known as betasatellites). Both bipartite and monopartite begomoviruses with associated satellites have previously been identified in chillies showing leaf curl symptoms in Pakistan.

Results

A chilli plant (Capsicum annum) with chilli leaf curl disease symptoms was found to contain a begomovirus, a betasatellite and the DNA B component of Tomato leaf curl New Delhi virus (ToLCNDV). The begomovirus consisted of 2747 nucleotides and had the highest sequence identity (99%) with Pepper leaf curl Lahore virus (PepLCLV-[PK: Lah:04], acc. no. AM404179). Agrobacterium-mediated inoculation of the clone to Nicotiana benthamiana, induced very mild symptoms and low levels of viral DNA, detected in systemically infected leaves by PCR. No symptoms were induced in Nicotiana tabacum or chillies either in the presence or absence of a betasatellite. However, inoculation of PepLCLV with the DNA B component of ToLCNDV induced leaf curl symptoms in N. benthamiana, N. tabacum and chillies and viral DNA accumulated to higher levels in comparison to plants infected with just PepLCLV.

Conclusions

Based on our previous efforts aimed at understanding of diversity of begomoviruses associated with chillies, we propose that PepLCLV was recently mobilized into chillies upon its interaction with DNA B of ToLCNDV. Interestingly, the putative rep-binding iterons found on PepLCLV (GGGGAC) differ at two base positions from those of ToLCNDV (GGTGTC). This is the first experimental demonstration of the infectivity for a bipartite begomovirus causing chilli leaf curl disease in chillies from Pakistan and suggests that component capture is contributing to the emerging complexity of begomovirus diseases in the region.
Immunolocalization of TSOL18 and TSOL45-1A, the successful protective peptides against porcine cysticercosis, in Taenia solium oncospheres
Authors: Martinez-Ocaña Joel , Romero-Valdovinos Mirza , de Kaminsky Rina G , Maravilla Pablo , Flisser Ana
Published: January 2011

Taenia solium life cycle includes humans as definitive hosts and pigs as intermediate hosts. One of the measures to stop the life cycle of this parasite is by vaccination of pigs. In experiments performed in pigs with TSOL18 and TSOL45-1A, two recombinant T. solium proteins, 99.5% and 97.0% protection was induced, respectively. The purpose of this paper was to localize these antigens in all stages of the parasite (adult worms, oncospheres and cysticerci) by immunofluorescence, with the use of antibodies against TSOL18 and TSOL45-1A that were obtained from the pigs used in the vaccination experiment. Results show that TSOL18 and TSOL45-1A are expressed on the surface of T. solium oncospheres and not in tapeworms or cysticerci, indicating that they are stage-specific antigens. This, therefore, might explain the high level of protection these antigens induce against pig cysticercosis.
Salivary glands of primary Sjögren's syndrome patients express factors vital for plasma cell survival
Authors: Szyszko Ewa A , Brokstad Karl A , Øijordsbakken Gunnvor , Jonsson Malin V , Jonsson Roland , Skarstein Kathrine
Published: January 2011

Introduction

The presence of circulating Ro/SSA and La/SSB autoantibodies has become an important marker in the classification criteria for primary Sjögren's syndrome (pSS). Plasma cells producing these autoantibodies are mainly high affinity plasma cells originating from germinal centre reactions. When exposed to the right microenvironment these autoimmune plasma cells become long-lived and resistant to immunosuppressive treatment. Since autoimmune plasma cells have been detected in the salivary glands of SS patients, we wanted to investigate if the glandular microenvironment is suitable for plasma cell survival and if glandular residing plasma cells are the long-lived plasma cell subset.

Methods

Single, double and triple immunohistochemistry as well as immunofluorescence staining was performed on minor salivary gland tissue retrieved from pSS, chronically inflamed and normal subjects.

Results

We detected significant numbers of CD138+, non-proliferating, Bcl-2 expressing plasma cells in the salivary glands of pSS patients with high focus score (FS). Furthermore, we demonstrated that CXCL12 and interleukin (IL)-6 survival factors were highly expressed in pSS salivary gland epithelium and by focal mononuclear infiltrating cells. Notably, adipocytes when present in the salivary gland tissue were an important source of CXCL12. We clearly demonstrate that plasma cells are localised in close proximity to CXCL12 and IL-6 expressing cells and thus that the environment of salivary glands with high FS provide factors vital for plasma cell survival.

Conclusions

Plasma cells residing in the salivary glands of pSS patients with high FS showed phenotypic characteristics of the long-lived plasma cell subtype. Furthermore, the pSS salivary gland microenvironment provided niches rich in factors vital for plasma cell survival.
α-TEA cooperates with chemotherapeutic agents to induce apoptosis of p53 mutant, triple-negative human breast cancer cells via activating p73
Authors: Tiwary Richa , Yu Weiping , Sanders Bob G , Kline Kimberly
Published: January 2011

Introduction

Successful treatment of p53 mutant, triple-negative breast cancers (TNBC) remains a daunting challenge. Doxorubicin (DOXO) and cisplatin (CDDP) are standard-of-care treatments for TNBC, but eventually fail due to acquired drug resistance and toxicity. New treatments for overcoming drug resistance and toxicity in p53 mutant, TNBC are therefore badly needed. Unlike p53, p73 - a member of the p53 family - is usually not mutated in cancers and has been shown to regulate p53-mediated apoptotic signaling in p53-deficient cancers. Therefore, identification of anticancer agents that can activate p73 in p53-deficient cancers may provide a chemotherapeutic approach for treatment of p53 mutant cancers. Here we report on the reconstitution of the p53 tumor suppressor pathway in a p53-independent manner via p73 with combination treatments of α-TEA, a small bioactive lipid, plus DOXO or CDDP.

Methods

p53 mutant, TNBC cell lines MDA-MB-231, BT-20 and MDA-MB-468 were used to evaluate the anticancer effect of chemotherapeutic drugs and α-TEA using annexin V (FITC)/PI staining, western blot analyses, RT-PCR and siRNA knockdown techniques.

Results

Combination treatments of α-TEA plus DOXO or CDDP act cooperatively to induce apoptosis, caspase-8 and caspase-9 cleavage, p73, phospho-c-Ab1 and phospho-JNK protein expression, and increase expression of p53 downstream mediators; namely, death receptor-5, CD95/APO-1 (Fas), Bax and Noxa, as well as Yap nuclear translocation - plus reduce expression of Bcl-2. Knockdown of p73, c-Abl, JNK or Yap using siRNAs shows that p73 plays a critical role in combination treatment-enhanced apoptosis and the expression of pro-apoptotic and anti-apoptotic mediators, and that c-Abl, JNK and Yap are upstream mediators of p73 in combination treatment responses.

Conclusions

Data show that α-TEA in combination with DOXO or CDDP synergistically enhances apoptosis in TNBC via targeting p53-mediated genes in a p73-dependent manner, and that p73 responses are downstream of c-Abl, JNK and Yap.
Geoelectric experimental design — Efficient acquisition and exploitation of complete pole-bipole data sets
Authors: Blome Mark , Maurer Hansruedi , Greenhalgh Stewart
Published: January 2011

Exploiting the information content offered by geoelectric data in an efficient manner requires careful selection of the electrode configurations to be used. This can be achieved using sequential experimental design techniques proposed over the past few years. However, these techniques become impractical when large-scale 2D or 3D experiments have to be designed. Even if sequential experimental design were applicable, acquisition of the resulting data sets would require an unreasonably large effort using traditional multielectrode arrays. We present a new, fully parallelized pole-bipole measuring strategy by which large amounts of data can be acquired swiftly. Furthermore, we introduce a new experimental design concept that is based on “complete” data sets in terms of linear independence. Complete data sets include a relatively small number of basis electrode configurations, from which any other configuration can be reconstructedby superposition. The totality of possible configurations is referred to as the comprehensive data set. We demonstrate the benefits of such reconstructions using eigenvalue analyses for the case of noise-free data. In the presence of realistic noise, such reconstructions lead to unstable results when only four-point (bipole-bipole) configurations are considered. In contrast, complete three-point (pole-bipole) data sets allow more stable reconstructions. Moreover, complete pole-bipole data sets can be acquired very efficiently with a fully parallelized system. Resolution properties of complete pole-bipole data sets are illustrated using both noise-free and noisy synthetic data sets. We also show results from a field survey performed over a buried waste disposal site, which further demonstrates the usefulness of our approach. Although this paper is restricted to 2D examples, it is trivial to extend the concept to 3D surveys, where the advantages of parallelized pole-bipole data acquisition become very significant.
Full-azimuth subsurface angle domain wavefield decomposition and imaging Part I: Directional and reflection image gathers
Authors: Koren Zvi , Ravve Igor
Published: January 2011

We present a new subsurface angle-domain seismic imaging system for generating and extracting high-resolution information about subsurface angle-dependent reflectivity. The system enables geophysicists to use all recorded seismic data in a continuous fashion directly in the subsurface local angle domain (LAD), resulting in two complementary, full-azimuth, common-image-angle gather systems: directional and reflection. The complete set of information from both types of angle gathers leads to accurate, high-resolution, reliable velocity model determination and reservoir characterization. The directional angle decomposition enables the implementation of specular and diffraction imaging in real 3D isotropic/anisotropic geological models, leading to simultaneous emphasis on continuous structural surfaces and discontinuous objects such as faults and small-scale fractures. Structural attributes at each subsurface point, e.g., dip, azimuth and continuity, can be derived directly from the directional anglegathers. The reflection-angle gathers display reflectivity as a function of the opening angle and opening azimuth. These gathers are most meaningful in the vicinity of actual local reflecting surfaces, where the reflection angles are measured with respect to the derived background specular direction. The reflection-angle gathers are used for automatic picking of full-azimuth angle-domain residual moveouts (RMO) which, together with the derived background orientations of the subsurface reflection horizons, provide a complete set of input data to isotropic/anisotropic tomography. The full-azimuth, angle-dependent amplitude variations are used for reliable and accurate amplitude versus angle and azimuth (AVAZ) analysis and reservoir characterization. The proposed system is most effective for imaging and analysis below complex structures, such as subsalt and subbasalt, high-velocity carbonate rocks, shallow low-velocity gas pockets, and others. In addition, it enables accurate azimuthal anisotropic imaging and analysis, providing optimal solutions for fracture detection and reservoir characterization.
Psychopharmacology in children with intellectual disability
Authors: Bramble David
Published: January 2011

Children and adolescents with intellectual disability have high rates of psychiatric morbidity, the most common presentation being behavioural difficulties, especially in the context of autism. This clinical review describes the applicability of the full range of current psychopharmacological agents to the mental health difficulties commonly encountered in clinical practice in this field, with an emphasis on informing the choice of an initial ‘best fit’ single agent for the various clusters of symptoms and signs presented by individual patients. It is emphasised that the evidence base for most practice parameters in this area is extremely modest and that a high level of caution is recommended when applying this information in everyday practice. The article also discusses some of the specific difficulties and challenges encountered within the field and makes some practical suggestions for good practice.
Letter from Australia: mental healthcare in Victoria
Authors: Castle David J.
Published: January 2011

Mental health services in the state of Victoria, Australia, have undergone enormous change over the past 15 years, with the closure of all stand-alone psychiatric hospitals and a shift of resources and services into the community. Although successful overall, various areas cause concern, including pressure on acute beds, a paucity of alternative residential options, and suboptimal integration of government and non-government agencies concerned with the care of people with mental illnesses. Certain groups, notably those with complex symptom sets such as substance use and mental illness, intellectual disability and forensic problems, remain poorly catered for by the system. Finally, community stigma and lack of work inclusion for mentally ill individuals are ongoing challenges.