bluuebunny/crossref_metadata_2025 huggingface dataset:
The Impact of Telemedicine Visits on the Controlling High Blood Pressure Quality Measure During the COVID-19 Pandemic: Retrospective Cohort Study
Authors: Ye Siqin , Anstey D Edmund , Grauer Anne , Metser Gil , Moise Nathalie , Schwartz Joseph , Kronish Ian , Abdalla Marwah
Published: February 2022

Background

Telemedicine visit use vastly expanded during the COVID-19 pandemic, and this has had an uncertain impact on cardiovascular care quality.

Objective

We sought to examine the association between telemedicine visits and the failure to meet the Controlling High Blood Pressure (BP) quality measure from the Centers for Medicare & Medicaid Services.

Methods

This was a retrospective cohort study of 32,727 adult patients with hypertension who were seen in primary care and cardiology clinics at an urban, academic medical center from February to December 2020. The primary outcome was a failure to meet the Controlling High Blood Pressure quality measure, which was defined as having no BP recorded or having a last recorded BP of ≥140/90 mm Hg (ie, poor BP control). Multivariable logistic regression was used to assess the association between telemedicine visit use during the study period (none, 1 telemedicine visit, or ≥2 telemedicine visits) and poor BP control; we adjusted for demographic and clinical characteristics.

Results

During the study period, no BP was recorded for 2.3% (486/20,745) of patients with in-person visits only, 27.1% (1863/6878) of patients with 1 telemedicine visit, and 25% (1277/5104) of patients with ≥2 telemedicine visits. After adjustment, telemedicine use was associated with poor BP control (1 telemedicine visit: odds ratio [OR] 2.06, 95% CI 1.94-2.18; P<.001; ≥2 telemedicine visits: OR 2.49, 95% CI 2.31-2.68; P<.001; reference: in-person visits only). This effect disappeared when the analysis was restricted to patients with at least 1 recorded BP (1 telemedicine visit: OR 0.89, 95% CI 0.83-0.95; P=.001; ≥2 telemedicine visits: OR 0.91, 95% CI 0.83-0.99; P=.03).

Conclusions

Increased telemedicine visit use is associated with poorer performance on the Controlling High Blood Pressure quality measure. However, telemedicine visit use may not negatively impact BP control when BP is recorded.
Implementation of a Brief Dialectical Behavioral Therapy Skills Group in High Schools for At-Risk Youth: Protocol for a Mixed Methods Study
Authors: Zapolski Tamika , Whitener MacKenzie , Khazvand Shirin , Crichlow Queenisha , Revilla Rebecca , Salgado Eduardo F , Aalsma Matthew , Cyders Melissa , Salyers Michelle , Wu Wei
Published: February 2022

Background

Adolescence is a developmental period marked by engagement in risk-taking behaviors, especially among impulsive or emotionally dysregulated youth. Thus, interventions that teach skills to reduce the risk of negative outcomes associated with emotional dysregulation are required. Social and emotional learning (SEL) programs have been developed to address both adolescent emotional dysregulation and risk-taking behaviors; however, current programs have mostly been implemented among younger youth and are used as a tier 1 universal intervention rather than a targeted tier 2 intervention for youth identified with emotional regulation difficulties.

Objective

This study aimed to address the need for SEL programming that can be delivered in schools, particularly for older youth who have difficulties with emotional or behavioral dysregulation, to reduce the risk of health-risk behaviors among this population.

Methods

Here, we outline the implementation of an SEL intervention titled Going 4 Goals, a 9-session adaptation of the Dialectical Behavioral Therapy for Adolescents (DBT-A) program delivered to at-risk high school students in a school setting. The primary objectives of the study are to test whether participating in the skills group intervention produces significant increases in the core DBT-A skills of mindfulness, emotional regulation, distress tolerance, and interpersonal effectiveness, while also producing significant decreases in substance use and risky behaviors. These primary outcomes are based on changes in participant scores between baseline and after the intervention and follow-ups at 1, 3, and 6 months compared with a control group of youth participating in the school’s health curriculum at the same time points. Qualitative interviews will also be conducted with intervention participants and school staff to examine acceptability and facilitators of and barriers to the intervention.

Results

A total of 171 participants across 13 groups had been enrolled in the intervention, with data collection ending December 2021. Data analysis will begin in the spring of 2022, with expected results to be published in the spring of 2023.

Conclusions

This paper describes the protocol of the 9-session school-based adaptation of the DBT-A intervention and discusses the strengths and limitations of the study and future directions.

International Registered Report Identifier (IRRID)

DERR1-10.2196/32490
Toward Human Digital Twins for Cybersecurity Simulations on the Metaverse: Ontological and Network Science Approach
Authors: Nguyen Tam N
Published: February 2022

Background

Cyber defense is reactive and slow. On average, the time-to-remedy is hundreds of times larger than the time-to-compromise. In response, Human Digital Twins (HDTs) offer the capability of running massive simulations across multiple domains on the Metaverse. Simulated results may predict adversaries' behaviors and tactics, leading to more proactive cyber defense strategies. However, current HDTs’ cognitive architectures are underdeveloped for such use.

Objective

This paper aims to make a case for extending the current digital cognitive architectures as the first step toward more robust HDTs that are suitable for realistic Metaverse cybersecurity simulations.

Methods

This study formally documented 108 psychology constructs and thousands of related paths based on 20 time-tested psychology theories, all of which were packaged as Cybonto—a novel ontology. Then, this study applied 20 network science centrality algorithms in ranking the Cybonto psychology constructs by their influences.

Results

Out of 108 psychology constructs, the top 10 are Behavior, Arousal, Goals, Perception, Self-efficacy, Circumstances, Evaluating, Behavior-Controllability, Knowledge, and Intentional Modality. In this list, only Behaviors, Goals, Perception, Evaluating, and Knowledge are parts of existing digital cognitive architectures. Notably, some of the constructs are not explicitly implemented. Early usability tests demonstrate that Cybonto can also be useful for immediate uses such as manual analysis of hackers’ behaviors and automatic analysis of behavioral cybersecurity knowledge texts.

Conclusions

The results call for specific extensions of current digital cognitive architectures such as explicitly implementing more refined structures of Long-term Memory and Perception, placing a stronger focus on noncognitive yet influential constructs such as Arousal, and creating new capabilities for simulating, reasoning about, and selecting circumstances.
COVID-19 Mental Health Stressors of Health Care Providers in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) Intervention: Qualitative Study
Authors: Sato Christa , Adumattah Anita , Abulencia Maria Krisel , Garcellano Peter Dennis , Li Alan Tai-Wai , Fung Kenneth , Poon Maurice Kwong-Lai , Vahabi Mandana , Wong Josephine Pui-Hing
Published: February 2022

Background

Since the pandemic, more Canadians have reported poorer mental health. A vital group experiencing a high level of stressors consists of health care providers (HCPs) caring for COVID-19 patients, carrying out public health responses, or working with vulnerable populations. The mental health of HCPs is negatively affected by the pandemic, not only at work but also at home and in the community. Intersecting stressors at multiple levels contribute to HCPs’ experiences of fatigue, insomnia, anxiety, depression, and posttraumatic stress symptoms.

Objective

The aim of this qualitative study was to explore the pandemic stressors experienced by HCPs at work, at home, and in the community before participating in the Pandemic Acceptance and Commitment to Empowerment Response (PACER) online intervention.

Methods

Informed by a social ecological approach, we used a qualitative reflective approach to engage 74 HCPs in diverse roles. Data were collected during the first 2 waves of the COVID-19 pandemic (June 2020 to February 2021) in Canada.

Results

Informed by a social ecological framework, 5 overarching themes were identified in our thematic analysis: (1) personal level stressors that highlight HCPs’ identities and responsibilities beyond the workplace; (2) interpersonal level stressors from disrupted social relationships; (3) organizational stressors that contributed to unsettled workplaces and moral distress; (4) community and societal stressors attributed to vicarious trauma and emotional labor; and (5) the multilevel and cumulative impacts of COVID-19 stressors on HCPs’ health.

Conclusions

COVID-19 is not merely a communicable disease but also a social and political phenomenon that intensifies the effects of social inequities. Current understanding of pandemic stressors affecting HCPs is largely partial in nature. Although workplace stressors of HCPs are real and intense, they need to be explored and understood in the context of stressors that exist in other domains of HCPs’ lives such as family and community to ensure these experiences are not being silenced by the “hero” discourses or overshadowed by professional demands.
Identifying COVID-19 Outbreaks From Contact-Tracing Interview Forms for Public Health Departments: Development of a Natural Language Processing Pipeline
Authors: Caskey John , McConnell Iain L , Oguss Madeline , Dligach Dmitriy , Kulikoff Rachel , Grogan Brittany , Gibson Crystal , Wimmer Elizabeth , DeSalvo Traci E , Nyakoe-Nyasani Edwin E , Churpek Matthew M , Afshar Majid
Published: February 2022

Background

In Wisconsin, COVID-19 case interview forms contain free-text fields that need to be mined to identify potential outbreaks for targeted policy making. We developed an automated pipeline to ingest the free text into a pretrained neural language model to identify businesses and facilities as outbreaks.

Objective

We aimed to examine the precision and recall of our natural language processing pipeline against existing outbreaks and potentially new clusters.

Methods

Data on cases of COVID-19 were extracted from the Wisconsin Electronic Disease Surveillance System (WEDSS) for Dane County between July 1, 2020, and June 30, 2021. Features from the case interview forms were fed into a Bidirectional Encoder Representations from Transformers (BERT) model that was fine-tuned for named entity recognition (NER). We also developed a novel location-mapping tool to provide addresses for relevant NER. Precision and recall were measured against manually verified outbreaks and valid addresses in WEDSS.

Results

There were 46,798 cases of COVID-19, with 4,183,273 total BERT tokens and 15,051 unique tokens. The recall and precision of the NER tool were 0.67 (95% CI 0.66-0.68) and 0.55 (95% CI 0.54-0.57), respectively. For the location-mapping tool, the recall and precision were 0.93 (95% CI 0.92-0.95) and 0.93 (95% CI 0.92-0.95), respectively. Across monthly intervals, the NER tool identified more potential clusters than were verified in WEDSS.

Conclusions

We developed a novel pipeline of tools that identified existing outbreaks and novel clusters with associated addresses. Our pipeline ingests data from a statewide database and may be deployed to assist local health departments for targeted interventions.
Evaluation of the Dengue Surveillance System in Khyber Pakhtunkhwa Province, Pakistan, in 2020
Authors: Khan Omar Sharif
Published: February 2022

Background

Installation and actualization of a disease surveillance system are prerequisites for early detection of outbreaks. Prompt response is possible when a robust surveillance system is in place. Dengue is one of the many diseases endemic to Pakistan and is potentially fatal.

Objective

This study aimed to assess the current dengue surveillance system and its performance and to provide recommendations to stakeholders for its actualization and improvement.

Methods

A cross-sectional study was conducted in 2020 to document the outcomes. The evaluation was guided by the updated Centers for Disease Control and Prevention guidelines for public health surveillance for the year 2019. A structured questionnaire was designed and piloted to estimate the simplicity, flexibility, acceptability, and stability of the current dengue surveillance system. The sample included 45 provincial- and district-level staff involved in dengue surveillance. Provincial data on dengue were analyzed to evaluate completeness, quality, positive predictive value, sensitivity, and representativeness. Field visits to districts were performed to assess data flow and timeliness.

Results

The reporting rate ranged from 12/100,000 in 2017 to 21/100,000 in 2019, with a total of 7641 reported cases in the province. The mean time of reporting cases was 1 day (range 0-2 days). The simplicity of the dengue surveillance system was at 90% with respect to structure and data flow. The stability of the system was at 84% because of data backup. System flexibility was at 81% and allowed the addition and modification of variables. The average completeness of the selected variables was 65%. About 59% of the staff interviewed considered the system acceptable. Data quality was suboptimal at 48%. The representativeness of the system was at 40%, and it was mainly representative of secondary and tertiary health care hospitals, particularly inpatients. The system positive predictive value for dengue was 15% and sensitivity was 14%, which were below par. The dengue surveillance system can detect dengue outbreaks early.

Conclusions

An immediate, collaborative, multisectoral, and transdisciplinary plan is needed to enhance reporting from all health facilities. Adequate government funding is needed to improve data quality, and a monitoring mechanism is needed at all levels for prompt functioning of the surveillance system.
Virtual Dermatology and the COVID-19 Pandemic in a Resource-Limited Country Such as Nepal
Authors: Jha Krishna , Jha Anil Kumar
Published: February 2022

Background

The COVID-19 pandemic has caused nationwide lockdown, which led to the disruption of health services. Despite being a rising health care modality in Nepal, virtual dermatology services became an effective tool to provide dermatologic care through web-based consultations throughout the country. Therefore, we assessed the implementation of teledermatology services at our center to provide uninterrupted health services across the country during the pandemic.

Objective

This study aimed to evaluate the clinicodemographic profile of patients using teledermatology services and patient acceptance of this service.

Methods

A retrospective, single-center, observational study was carried out. Clinicodemographic data from the patients using teledermatology services were obtained and analyzed. A set of questionnaires regarding patients’ acceptance of teledermatology services were administered to the patients through a survey via telephone calls, and the obtained data were interpreted.

Results

A total of 122 teleconsultations were carried out within the country. The mean age of patients was 33.48 (SD 17.89) years. Of these 122 patients, 79 (64.8%) were from outside and 43 (35.2%) were from inside the city where the institute is located. The average distance from the institute to the patients’ residence was approximately 144.84 (SD 157.20) km, and the mean travel time was approximately 385.31 (SD 889.52) minutes. In total, 89 patients could be contacted, of whom 81 (91%) found the service easy to use, 75 (84.3%) were able to express their problems in a manner similar to that during direct visits, 49 (55.05 %) thought that the teleconsultation was the same as an in-person visit, 80 (89.9%) were satisfied, and 85 (95.5%) agreed to use teledermatology services in the future. Superficial fungal infection was the most common diagnosis (24.6 %). Newly registered patients were more satisfied than follow-up patients (96.36% vs 79.41%, respectively; P=.01).

Conclusions

This study highlights the importance of virtual dermatology services to deliver dermatologic care during the pandemic in Nepal. In the future, this program has a promising role in providing health care services to meet the medical needs of patients.

Conflicts of Interest

None declared.
Interobserver and Human–Artificial Intelligence Concordance in Differentiating Between Invasive and In Situ Melanoma
Authors: Polesie Sam , Paoli John
Published: February 2022

Background

Machine learning algorithms including convolutional neural networks (CNNs) have recently made significant advances in research settings. Even though several algorithms nowadays are targeted directly to the consumer market, their implementation in clinical practice is still pending. Most melanomas are easy to recognize even without the aid of dermoscopy. Nonetheless, it is often more challenging to discriminate between invasive melanoma and melanoma in situ (MIS) in a preoperative setting even with the assistance of dermoscopy. Although several dermoscopic features suggestive of MIS and invasive melanomas have been presented, their usefulness in a larger setting is limited by how well physicians agree on their presence or absence.

Objective

The overarching aims of this research project are to identify useful dermoscopic features to help dermatologists predict melanoma thickness and to develop CNNs that can assist dermatologists in the preoperative assessment of melanoma thickness. The ultimate aim is to develop algorithms that can strengthen patient care, improve clinical decision-making, and be used in routine health care.

Methods

We have included dermoscopic images as well as clinical close-up images of invasive melanomas and MIS from our department during the time period of January 1, 2016, to December 31, 2020. Using this image material, we have trained, validated, and tested two separated CNNs based on dermoscopic and clinical close-up images. We have also invited dermatologists to review the test sets and, for a subset of the dermoscopic images, asked them to specify the presence of prespecified dermoscopic features. Subsequently, we compared CNN outputs to the combined dermatologists’ output for all lesions and assessed the interobserver agreement for several dermoscopic features.

Results

The CNN developed using dermoscopic images performed on par with the invited dermatologists whereas the CNN using clinical close-up images was outperformed by the group of dermatologists. Two dermoscopic features (atypical blue-white structures and shiny white lines) both displayed a moderate to substantial interobserver agreement and were both indicative of invasive melanomas >1.0 mm.

Conclusions

CNNs used to differentiate between invasive melanomas and MIS might be an example of a clinically relevant machine learning application, but they need further refinement and evaluation in prospective clinical trials. Only a few dermoscopic features are helpful in distinguishing melanoma thickness.

Conflicts of Interest

None declared.
COVID-19 Assessment and Testing in Rural Communities During the Pandemic: Cross-sectional Analysis (Preprint)
Authors: Fitzsimon Jonathan , Gervais Oliver , Lanos Chelsea
Published: February 2022

BACKGROUND

The COVID-19 pandemic exacerbated the need for urgent improvements in access to health care for rural, remote, and underserviced communities. The Renfrew County Virtual Triage and Assessment Centre (VTAC) was designed to provide access to COVID-19 testing and assessment with a family physician. The goal was to protect emergency departments and 911 paramedics while ensuring that nobody was left at home, suffering in silence. Residents were encouraged to call their own family physician for any urgent health needs. If they did not have a family physician or could not access their usual primary care provider, then they could call VTAC. This study reports on the output of a service model offering access to assessment and COVID-19 testing through a blend of virtual and in-person care options by a multidisciplinary team.

OBJECTIVE

The purpose of this study was to assess the ability of VTAC to provide access to COVID-19 assessment and testing across rural, remote, and underserviced communities.

METHODS

We conducted a cross-sectional analysis of the data derived from the cases handled by VTAC between March 27, 2020 (launch day), and September 30, 2020.

RESULTS

Residents from all 19 census subdivisions and municipalities of Renfrew County accessed VTAC. A total of 10,086 family physician assessments were completed (average 64 per day). Of these, 8535 (84.6%) assessments were to unique patient users. Thirty physicians provided care. Using digital equipment setup in the patients’ home, 31 patients were monitored remotely. VTAC community paramedics completed 14,378 COVID-19 tests and 3875 home visits.

CONCLUSIONS

Renfrew County’s experience suggests that there is tremendous synergy between family physicians and community paramedics in providing access to COVID-19 assessment and COVID-19 testing. The blended model of virtual and in-person care is well suited to provide improved access to other aspects of health care post pandemic, particularly for patients without a family physician.
Implementation and Experiences of Telehealth: Balancing Policies With Practice in Countries of South Asia, Kuwait, and the European Union (Preprint)
Authors: John Oommen , Sarbadhikari Suptendra Nath , Prabhu Thanga , Goel Ashvini , Thomas Alexander , Shroff Sunil , Allaudin Fazilah , Weerabaddana Chaminda , Alhuwail Dari , Koirala Udaya , Johnrose Jayalal , Codyre Patricia , Bleaden Andy , Singh Shubnum , Bajaj Shuchin
Published: February 2022

UNSTRUCTURED

This viewpoint summarizes the discussion that occurred during the “Translating Policy to Practice in Telehealth–Lessons from Global Implementation Experiences” panel that was held virtually at Telemedicon2020, December 18-20, 2020. This panel brought together policy and implementation experts from some countries of South Asia, Kuwait, and the European Union to share their experiences in the development and implementation of telehealth standards and of the scale up of telehealth interventions within health systems. Several common themes arose from the discussion, including the significant role of people; encouragement by respective government policymakers; addressing concerns, particularly related to privacy, confidentiality, and security; and capacity building of human resources. These are discussed in turn, along with the future directions identified by the panelists, which emphasized the need for active encouragement toward the adoption and diffusion of digital health in general and of telehealth in particular. All stakeholders, ranging from governmental policymakers to common citizens, need to come together to build trusting partnerships to realize the advantages offered by telehealth.
Statistical Considerations for Analyzing and Interpreting Data from Biometric Monitoring Technologies (BioMeTs) in Clinical Trials (Preprint)
Authors: Ratitch Bohdana , Kunkoski Elizabeth , Fontanari Adriano , Onorati Francesco , Dabral Abhishek , Rodriguez-Chavez Isaac R. , Vandendriessche Benjamin , Vega Julio , Morton Stuart , Damestani Yasaman
Published: February 2022

UNSTRUCTURED

The proliferation and increasing maturity of biometric monitoring technologies allows clinical investigators to measure the health status of trial participants in a more holistic manner, especially outside of clinical settings. This includes capturing meaningful aspects of health in daily living and in a more granular and objective manner compared to traditional tools in clinical settings. Within multidisciplinary teams, statisticians and data scientists are increasingly involved in clinical trials that incorporate digital clinical measures and are called upon to provide input into study planning, generation of evidence on the clinical validity of novel clinical measures, and evaluation of the adequacy of existing evidence. Analysis objectives related to demonstrating clinical validity of novel clinical measures differ from typical objectives related to demonstrating safety and efficacy of therapeutic interventions using established measures which statisticians are most familiar with. This paper discusses statistical considerations for generating evidence for clinical validity through the lens of the type and intended use of a clinical measure. This paper also briefly discusses the regulatory pathways through which clinical validity evidence may be reviewed and highlights challenges that statisticians and data scientists may encounter while dealing with data from biometric monitoring technologies.
Exploring the applicability of using natural language processing to support nationwide venous thromboembolism surveillance (Preprint)
Authors: Wendelboe Aaron , Saber Ibrahim , Dvorak Justin , Adamski Alys , Feland Natalie , Reyes Nimia , Abe Karon , Ortel Thomas , Raskob Gary
Published: February 2022

BACKGROUND

Conducting public health surveillance for venous thromboembolism (VTE) at a national scale is important for measuring the disease burden and the impact of prevention measures. Integrating natural language processing (NLP) into VTE surveillance may be an efficient and accurate option in establishing a sustainable and cost-effective national surveillance system.

OBJECTIVE

We evaluated the performance of the VTE identification instance of IDEAL-X, an NLP tool, in automatically classifying cases of VTE from “reading” unstructured text from diagnostic imaging records.

METHODS

Accessing imaging records from pilot surveillance systems for VTE from Duke University and the University of Oklahoma Health Sciences Center (OUHSC) during 2012–2014, we used a VTE identification model of IDEAL-X to classify cases of VTE that had previously been manually classified according to pre-defined criteria. The performance measures (and 95% confidence intervals [CI]) calculated were accuracy, sensitivity, specificity, and positive and negative predictive values.

RESULTS

The VTE model of IDEAL-X “read” 1591 records from Duke University and 1487 records from OUHSC for a total of 3078 records. The combined performance measures were 93.7% accuracy (95% CI: 93.7%–93.8%), 96.3% sensitivity (95% CI: 96.2%–96.4%), 92.0% specificity (95% CI: 91.9%–92.0%), 89.1% positive predictive value (95% CI: 89.0%–89.2%), and 97.3% negative predictive value (95% CI: 97.3%–97.4%). The sensitivity was higher at Duke University (97.9%, 95% CI: 97.8%–98.0%) than at OUHSC (93.8%, 95% CI: 93.5%–94.0%), but the specificity was higher at OUHSC (96.3%, 95% CI: 96.2%–96.3%) than at Duke University (90.4%, 95% CI: 90.1%–90.5%).

CONCLUSIONS

The VTE model of IDEAL-X accurately classified cases of VTE from pilot surveillance systems from 2 separate states and health systems. NLP is a promising tool in the design and implementation of an automated national surveillance system for VTE.
Web-based interventions for pregnant women with gestational diabetes mellitus: A systematic review and meta-analysis (Preprint)
Authors: Guo Pingping , Chen Dandan , Xu Ping , Wang Xiaojuan , Zhang Wei , Mao Minna , Zheng Qiong , Jin Yin , Feng Suwen
Published: February 2022

BACKGROUND

Gestational diabetes mellitus (GDM) is one of the most prevalent diseases during pregnancy and is closely related to considerable short-term and long-term maternal and neonatal complications, so effective management of GDM is essential. Web-based interventions (WBIs) have been applied to assist in managing GDM due to the advantages of high accessibility and efficiency, but findings across studies were inconsistent.

OBJECTIVE

This systematic review and meta-analysis aimed to comprehensively evaluate the efficacy of WBIs on maternal glycemic control, behavioral outcomes, cognitive and attitudinal outcomes, mental health, maternal and neonatal clinical outcomes, as well as medical service utilisation and costs in pregnant women with GDM.

METHODS

PubMed, Embase, Cochrane Library, Web of Science and CINAHL were searched from each database inception to January 2022 to identify relevant randomized controlled trials (RCTs) and controlled clinical trials (CCTs). The methodological quality of included studies were assessed using the Effective Public Health Practice Project tool. Meta-analysis was conducted using Stata 12.0 software. Three subgroup analyses regarding the intervention interactivity, format and technology were also performed based on the outcome data of glycaemic control parameters.

RESULTS

A total of 22 publications arising from 19 RCTs/CCTs were included. The overall meta-analyses on glycemic control parameters demonstrated that compared with the control group, WBIs could significantly improve fasting blood glucose (SMD =-1.95, 95% CI [-3.29, -.61]; P=.004) and 2‑hour postprandial blood glucose (SMD =-1.53, 95%CI [-2.82, -.25]; P=.02), while no significant effect was found on glycated haemoglobin and 1‑hour postprandial blood glucose. The results of subgroup analyses indicated that mobile application-delivered interventions with personalized format and interactive function showed more beneficial effects on maternal glycemic control. Moreover, WBIs could jointly enhance the compliance with self-monitoring of blood glucose, improve the satisfaction with care, increase normal vaginal delivery, as well as decrease emergency caesarean and composite neonatal complication, while the effectiveness on other outcomes were either not significant or inconclusive.

CONCLUSIONS

WBIs are promising approaches for GDM management. Personalized, interactive and mobile application-delivered interventions seems to be more worthy of being recommended for future clinical practice. More high-quality studies are required to verify these findings before strong recommendations.

CLINICALTRIAL

PROSPERO CRD 42022296625;https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=296625
Recuerdos de juventud de un imperialista exiliado
Authors: Viveros Anaya Luz América
Published: February 2022

En el artículo se propone una revisión de José Manuel Hidalgo y Esnaurrízar (1826-1896) como cronista de la vida en las cortes europeas, novelista del mundo aristócrata y autor del texto autobiográfico  Recuerdos de juventud  (1887). El estudio del autor fue obstaculizado durante más de un siglo por la visión negativa que se tuvo de su actuación política durante la Intervención Francesa y el Segundo Imperio. Sin embargo,  Recuerdos de juventud  revela la modernidad de su concepción ya que fue publicado entre los primeros que propiciaron el surgimiento del espacio autobiográfico en México. José Hidalgo recuerda su juventud como miembro de la legación de México en Roma, cuando el Papa Pío IX se encontraba refugiado en Gaeta por los conflictos políticos de mediados de siglo. En el artículo se señalan algunas características de la autofiguración del autor y los propósitos que pudo perseguir con su escritura.
El espacio del islam “vivo” en los Altos de Chiapas
Authors: González Calderón Silvia , Leyva Cortés Samantha , Quintana Noriega María Carolina
Published: February 2022

San Cristóbal de Las Casas es una ciudad dinámica y compleja, entre otras cosas por alojar diferentes interpretaciones en torno a lo sagrado que la convierten en un espacio de disputa entre diversos grupos religiosos, entre ellos los musulmanes de reciente aparición. La presencia del islam en la región de los Altos de Chiapas está estrechamente relacionada con la expulsión de indígenas conversos al protestantismo de San Juan Chamula. En San Cristóbal de las Casas, actualmente se ubica una población aproximada de 300 musulmanes, en su mayoría chamulas.La relevancia de la presencia del islam en Chiapas se manifiesta en una de sus mezquitas: Imam Malik, considerada el centro islámico de oración más ambicioso en México por su construcción, materiales y extensión. Los distintos inmuebles materializan el islam por medio de la orientación, el color, la ornamentación y la disposición, sin marginar la lógica y función de áreas fundamentadas en la jurisprudencia islámica, sin embargo, se adaptan a dinámicas, tradiciones y visiones particulares como la chamula.
A Study on Types of Cyber Crimes and Cyber Attacks Today
Authors: Lodh Anushka Alok , Dalave Chetan Vijaykumar
Published: February 2022

Abstract: With the increasing number of COVID-19 cases in the world and deaths worldwide has given a very worse condition to the whole world besides this covid pandemic there is also increase in number of Cyber-crimes and Cyber-attack of different types in the whole world. As Technology is advancing everyday there is a rise in Cyber-crime problem today, however security measures and prevention to protect this technology and the users of the technology is not advancing as quickly. So, the aim of this study is to understand and learn different types of Cybercrimes and Cyberattacks today in the world. It is important to prevent and to put awareness about the types of crimes and attacks. There are some protective procedures such as keep your software Up to date, Using of Anti-Virus Protection and also the use of Firewall, Continuously Changing Passwords and keep it as strong as can be, and also two step or multi step authentication should be done whenever necessary. Keywords: Cyber-crimes, Cyber-attacks, Types of Cyber-crimes, Prevention Measures, Threats
IOT Based Person/Wheelchair Fall Detection System
Authors: Kamble Sayali M. , Kawle Pratiksha R. , Mohile Suwarna S. , Meshram Megha R. , Mam Prof. Gayatri Padole , Mam Neetu Gyanchandani
Published: February 2022

Abstract: Keeping an in depth tab of recent folks or folks on chair with bound health conditions for his or her health and safety is a very important task. With maturity, weak bones and weakness because of alternative health connected problems could lead to will increase risk of falling. A supervisor might not continually be on the market with them and if correct assistance is not provided at the correct time it should cause larger health considerations which will need extra resources for treatment. For this purpose we've projected a wise IOT Fall Detection System exploitation acceptable sensors that square measure integrated facilitate to assist} report these incidents to assist avail help at the correct time to forestall additional injury to health. The same system uses sensors like associate degree measuring system to live the speed of the person, a rotating mechanism to live the person’s orientation so as to live their stability, a load sensing element once the system is employed by an individual employing a chair to live their weight, a Wi-Fi module and a microcontroller that sends the general readings to alert the involved those that shall give with the right suggests that to assist the person in want. The microcontroller receives all the info from the sensors and perpetually transmits and monitors the acceleration and also the orientation of the person. Any fast abrupt modification within the system which will result from a fall is taken into account as a ‘fall’ and is reported. A serious concern would be that not all fast movement may end up from a fall and be thought of as a matter of concern. To avoid this warning a nap button is provided to snooze the system. This button will be ironed before a definite time say 15-30 seconds to prevent the system from causation the alert, thus avoiding any confusion and panic. This method will be mounted to the person’s chair or will be created compact to be created into a wearable device which will be worn on the hand. Keywords: Measuring system, Gyro meter, Microcontroller
Optimization of System Authentication Services using Blockchain Technology
Authors: Riadi Imam , Herman Herman , Ifani Aulyah Zakilah
Published: February 2022

With the development of the era, one thing that must be considered for security is the Login System. In most cases, user login information is stored on the server. This gives access to sensitive informatio, many hackers easily break into data from users. Based on these problems, this research focuses on data security authentication in the form of usernames and passwords in the login system. Authentication using blockchain is used to reduce malicious access and increase security for the authentication process. One of the innovative technologies that can solve these problems is Blockchain Technology. Using blockchain technology, hackers will find it difficult to change and modify the same data on all computers at the same time because it takes a very long time to crack the encryption code on each block of data in the entire computer network. Data storage or transactions in the blockchain are stored in the form of hashes. This makes it difficult for hackers to break into it. Tests in this study using Wireshark tools and network miner. Based on the research conducted, the test was conducted as many as 5 times with two scenarios, namely authentication of the login system before using the blockchain and after using the blockchain. The results obtained. The, system built using blockchain can secure data. The test results obtained that data in the form of usernames and passwords were converted into hashes and with the immutable nature of the blockchain, data from users could not be changed or replaced by anyone.
Studi Komparatif Kemampuan Mahārah Qirā’ah Siswa Pesantren Salafi dan Khalafi di Aceh Barat, Indonesia
Authors: Mubshirah Dara
Published: February 2022

Arabic is one of the materials studied in modern (khalafi) and traditional (salafi) Islamic Boarding Schools (Pesantren). Reading comprehension ability (Mahārah Qira’āh) is one of the crucial skills in learning Arabic. This study aimed to determine the extent of the differences in the qirā’ah ability in Pesantren Khalafi and Salafi in West Aceh. This study uses a comparative method. To collect the data, the researcher employed tests on 50 students of Pesantren Salafi and 50 students Pesantren Khalafi. Whereas to analyze the data researcher employed the Mann Witney statistical test with a = 0.05. The results of this study showed that there was a difference between the Mahārah Qirā’ah ability of Students in Pesantren Khalafi and Salafi with the statistical value of reading lined texts (p-value (0.011) <α (0.05) and reading unlined books (p-value (0.043)) <α ( 0.05).
Effects of Thyme and Thyme Oil on Growth of White Shrimp, Litopenaeus vannamei
Authors: Aktaş Mevlüt , Genç Münevver Ayçe , Bircan Yıldırım Yasemin , Kaya Doğukan , Çalışıcı Özlem , Genç Ercüment
Published: February 2022

In this study, it was aimed to evaluate the effectiveness of different levels of thyme leaf and thyme oil as feed additives in white shrimp (Litopenaeus vannamei) culture. In the experiment, five groups were formed as 1% and 2% thyme leaves (ThyL1% and ThyL2%), 0.5% and 1% thyme oil (ThyO0.5% and ThyO1%), and control group. Shrimps (6.67±1.52 g) were stocked at a stocking rate of 15 shrimp/250 L (100% water change day-1) in a three-replications. At the end of the trial, the highest final body weight (14.90±2.77) and weight gain (8.22±0.72) were determined in the ThyO1% group and were statistically different compared to the control group (Final weight: 13.54±3.37, weight gain: 6.87±0.54) (p<0.05). While the best feed conversion ratio between the groups was similarly determined in the ThyO1% (2.59±0.92) group, there was no difference between the groups in terms of survival rates. Histological examination of hepatopancreatic tissues showed no difference in tissue morphology between the groups. Dry matter, crude protein, and crude ash contents did not differ significantly between the groups. The highest lipid content was found in the ThyO1% group (1.64) compared to the other groups (p<0.05). Saturated and unsaturated fatty acids composition values differed significantly for all groups. (p<0.05). As a result, it can be stated that 1% thyme oil added feed can be used as a growth promoter in white shrimp culture.
Perda de hábitat e o surgimento de epidemias: importância da socialização do conceito de Saúde Única na conscientização ambiental
Authors: Vítor dos Santos Rodrigues Israel , Silva Sousa Caine , Aguilar-Aleixo Luciana
Published: February 2022

A perda de hábitat causa perturbação da dinâmica ambiental, desequilibrando este pilar da Saúde Única ou “One Health”, e afetando os demais pilares: saúde animal e humana. Para que os impactos da ação antrópica sejam diminuídos, a divulgação científica tem sido grande aliada, popularizando o conhecimento e favorecendo a conscientização da população. Esta pesquisa-ação avalia o potencial da mesa-redonda online: “O que a evolução tem a nos dizer sobre a perda de hábitat e surgimento de epidemias?” na promoção da Saúde Única. O evento, realizado em 10 de setembro de 2020 pelo projeto de extensão universitária “Evolução para Todos”, proporcionou debate entre os palestrantes, das áreas de virologia e ecologia aplicada à conservação, e o público de 236 pessoas de diferentes formações e localidades, sobre aspectos evolutivos e ecológicos da pandemia por COVID-19. Após as palestras houve um debate com participação direta do público, esclarecendo dúvidas e ampliando a discussão de conceitos. Esta pesquisa-ação evidenciou que a divulgação científica é uma aliada essencial contra os impactos das ações antrópicas, que no contexto da temática, podem afetar os três pilares da Saúde Única. Os participantes trouxeram retorno positivo, demonstrando a importância de debates como este na conscientização da sociedade.
Retained bronchial foreign body diagnosed after 29 years of penetrating chest trauma -- A case report.
Authors: Pun Bishika , Rimal Ankit
Published: February 2022

This is a case of retained bronchial foreign body identified by Computed
tomography (CT) scan after 29 years of initial chest trauma in a patient
with long standing history of shortness of breath and recurrent
pulmonary infections eliciting the importance of CT scan in identifying
such foreign bodies.
Eruptive xanthomas as a marker for metabolic disorders: A specific form of xanthoma that reflects hypertriglyceridemia
Authors: Otaki Souichiro , Ashida Kenji , Matsuo Yuko , Moritaka Kanoko , Iwata Shimpei , Nagayama Ayako , Kawaguchi Aya , Koga Hiroshi , Yoshinobu Satoko , Hasuzawa Nao , Motomura Seiichi , Akiba Jun , Nomura Masatoshi , Nakama Takekuni
Published: February 2022

Eruptive xanthomas are skin manifestations associated with
hypertriglyceridemia. Accordingly, improvement of hypertriglyceridemia
can ameliorate this condition. We report a case of a patient with type 2
diabetes mellitus who was diagnosed with this skin lesion. Clinicians
should be aware that eruptive xanthomas could indicate metabolic
disorders associated with atherosclerosis.
Gill proteome networks explain energy homeostasis during salinity stress in Oreochromis mossambicus
Authors: Root Larken , Kültz Dietmar
Published: February 2022

Acclimations of Oreochromis mossambicus to elevated salinity were
conducted with multiple rates of salinity increase and durations of
exposure to determine the rate-independent maximum salinity limit and
the incipient lethal salinity. Quantitative proteomics of over 3000 gill
proteins simultaneously was performed to analyze molecular phenotypes
associated with treatments representative of key zones in the
salinity-level x duration matrix. For this purpose, a species- and
tissue-specific data-independent acquisition (DIA) assay library of MSMS
spectra was created. From these DIA data, protein networks representing
complex molecular phenotypes associated with salinity acclimation were
generated. Organismal performance indicators of salinity tolerance were
then correlated with salinity-regulated protein networks. O.
mossambicus was determined to have a wide “zone of resistance” from
approximately 75g/kg salinity to 120g/kg, which fish survive for a
limited period with eventual loss of function. Crossing the critical
threshold salinity into the zone of resistance corresponds with blood
osmolality increasing beyond 400 mOsm, significantly reduced body
condition factor, and cessation of feeding. Gill protein networks
impacted at extreme salinity levels both above and below the critical
salinity threshold include increased energy metabolism, especially
upregulation of electron transport chain proteins, and regulation of
specific osmoregulatory proteins. Cytoskeletal, cell adhesion, and
extracellular matrix proteins are enriched in regulation network
patterns that are sensitive to the critical salinity threshold. Network
analysis of these patterns provides deep insight into specific
mechanisms of energy homeostasis during salinity stress.
PACS-2 Ameliorates Tubular Injury by Facilitating Endoplasmic Reticulum-Mitochondria Contact and Mitophagy in Diabetic Nephropathy
Authors: Li Chenrui , Li Li , Yang Ming , Yang Jinfei , Zhao Chanyue , Han Yachun , Zhao Hao , Jiang Na , Wei Ling , Xiao Ying , Liu Yan , Xiong Xiaofen , Xi Yiyun , Luo Shilu , Deng Fei , Chen Wei , Yuan Shuguang , Zhu Xuejing , Xiao Li , Sun Lin
Published: February 2022

Mitochondria-associated endoplasmic reticulum membrane
(MAM) is emerging as a novel insight into tubular injury in diabetic
nephropathy (DN), but the precise mechanism remains unclear. Here, we demonstrate that the expression of phosphofurin
acidic cluster sorting protein 2 (PACS-2), a critical regulator of MAM
formation, is significantly decreased in renal tubules
of patients with DN, which is positively correlated with renal function and
negatively correlated with degrees of tubulointerstitial lesions. Conditional deletion of Pacs-2 in proximal tubules (PT)
aggravates albuminuria and tubular injury in streptozotocin (STZ)-induced diabetic
mice. Mitochondrial fragmentation,
MAM disruption and defective mitophagy accompanied by altered expression of
mitochondrial dynamics and mitophagic protein including DRP1 and BECN1 are
observed in tubules from diabetic mice, while these changes are more pronounced in
PT-specific Pacs-2 knockout mice. In vitro, overexpression of PACS-2 in HK-2 cells alleviates excessive
mitochondrial fission induced by high glucose through blocking mitochondrial
recruitment of DRP1, and subsequently restores MAM integrity and enhances
mitophagy. Mechanistically, PACS-2 binds to BECN1 and mediates the
relocalization of BECN1 to MAM where it promotes the formation of
mitophagosome. Together, these data
highlight an important but previously unrecognized role of PACS-2 in
ameliorating tubular injury in DN by facilitating MAM formation and
mitophagy.
Implementación del sistema Cross Docking para el proceso de distribución en una empresa de confección de prendas de vestir
Authors: Reyes Palomino Antonio José , Galofre Vásquez Marjorie , Fontalvo Cerpa Winston , Acuña Molina Norberto
Published: February 2022

La necesidad de disminuir los tiempos de respuesta en las entregas a los puntos de ventas y evacuar el producto terminado aglomerado en el área de almacenamiento temporal son las razones de crear una estructura formal de una guía de despacho. El objetivo del presente estudio fue desarrollar un sistema de distribución de prendas de vestir, que de manera automática designe la cantidad de prendas de vestir por enviar a cada almacén con solo digitar el lote de determinada talla y de manera inmediata elabore la guía, recurso indispensable para realizar el procedimiento de despacho. Para que la sistematización alcance el objetivo deseado, se utilizaron los porcentajes de recibos por día de los almacenes y se agruparon en cuatro categorías: grandes, medianos, centros comerciales y pequeños, utilizando como herramienta Microsoft Excel, la cual permite que se realicen las iteraciones secuenciales. Una vez se validó la información, se dio aplicabilidad a esta herramienta en complemento con la metodología Cross Docking, que consiste en reducir el tiempo de operatividad y almacenamiento temporal para lograr mejoras en el proceso, generando mayor flujo, distribuciones acordes con los pedidos, tendencia a cero en el almacenamiento temporal, entregas a tiempo, bases de información confiables, mayor exhibición e incremento en las ventas.