bluuebunny/crossref_metadata_2025 huggingface dataset:
Multiple Roles of the Small GTPase Rab7
Authors: Guerra Flora , Bucci Cecilia
Published: August 2016

Rab7 is a small GTPase that belongs to the Rab family and controls transport to late endocytic compartments such as late endosomes and lysosomes. The mechanism of action of Rab7 in the late endocytic pathway has been extensively studied. Rab7 is fundamental for lysosomal biogenesis, positioning and functions, and for trafficking and degradation of several signaling receptors, thus also having implications on signal transduction. Several Rab7 interacting proteins have being identified leading to the discovery of a number of different important functions, beside its established role in endocytosis. Furthermore, Rab7 has specific functions in neurons. This review highlights and discusses the role and the importance of Rab7 on different cellular pathways and processes.
Research on the Combustion Characteristics of a Free-Piston Gasoline Engine Linear Generator during the Stable Generating Process
Authors: Miao Yuxi , Zuo Zhengxing , Feng Huihua , Guo Chendong , Song Yu , Jia Boru , Guo Yuyao
Published: August 2016

The free-piston gasoline engine linear generator (FPGLG) is a new kind of power plant consisting of free-piston gasoline engines and a linear generator. Due to the elimination of the crankshaft mechanism, the piston motion process and the combustion heat release process affect each other significantly. In this paper, the combustion characteristics during the stable generating process of a FPGLG were presented using a numerical iteration method, which coupled a zero-dimensional piston dynamic model and a three-dimensional scavenging model with the combustion process simulation. The results indicated that, compared to the conventional engine (CE), the heat release process of the FPGLG lasted longer with a lower peak heat release rate. The indicated thermal efficiency of the engine was lower because less heat was released around the piston top dead centre (TDC). Very minimal difference was observed on the ignition delay duration between the FPGLG and the CE, while the post-combustion period of the FPGLG was significantly longer than that of the CE. Meanwhile, the FPGLG was found to operate more moderately due to lower peak in-cylinder gas pressure and a lower pressure rising rate. The potential advantage of the FPGLG in lower NOx emission was also proven with the simulation results presented in this paper.
Secondary Metabolites in Ramalina terebrata Detected by UHPLC/ESI/MS/MS and Identification of Parietin as Tau Protein Inhibitor
Authors: Cornejo Alberto , Salgado Francisco , Caballero Julio , Vargas Reinaldo , Simirgiotis Mario , Areche Carlos
Published: August 2016

Liquid chromatography coupled with mass spectrometry is an outstanding methodology for fast analysis of phenolic compounds in biological samples. Twenty two compounds were quickly and accurately identified in the methanolic extract of the Antarctic lichen Ramalina terebrata for the first time using ultra high pressure liquid chromatography coupled with photodiode array detector and high resolution mass spectrometry (UHPLC-PDA-Q/Orbitrap/MS/MS). In addition, the extract and the four compounds isolated from this species were tested for the inhibitory activity of tau protein aggregation, which is a protein involved in Alzheimer’s disease (AD). All compounds showed null activity with the exception of parietin, which it was able to inhibit aggregation process of tau in a concentration range between 3 µg/mL (10 µM) to 28 µg/mL (100 µM). In addition, we show how parietin interact with tau 306VQIVYK311 hexapeptide inside of the microtubule binding domain (4R) with the help of molecular docking experiments. Finally, the constituents present in the methanolic extract could possibly contribute to the established anti-aggregation activity for this extract and this in-depth analysis of the chemical composition of R. terebrata could guide further research into its medicinal properties and potential uses.
MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2
Authors: Fujii Tomomi , Shimada Keiji , Asano Aya , Tatsumi Yoshihiro , Yamaguchi Naoko , Yamazaki Masaharu , Konishi Noboru
Published: August 2016

Aberrant expression of microRNAs (miRNAs) is involved in the development and progression of various types of cancers. In this study, we investigated the role of miR-331-3p in cell proliferation and the expression of keratinocyte differentiation markers of uterine cervical cancer cells. Moreover, we evaluated whether neuropilin 2 (NRP2) are putative target molecules that regulate the human papillomavirus (HPV) related oncoproteins E6 and E7. Cell proliferation in the human cervical cancer cell lines SKG-II, HCS-2, and HeLa was assessed using the 3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium, inner salt (MTS) assay. Cellular apoptosis was measured using the TdT-mediated dUTP nick end labeling (TUNEL) and Annexin V assays. Quantitative RT-PCR was used to measure the messenger RNA (mRNA) expression of the NRP2, E6, E7, p63, and involucrin (IVL) genes. A functional assay for cell growth was performed using cell cycle analyses. Overexpression of miR-331-3p inhibited cell proliferation, and induced G2/M phase arrest and apoptosis in SKG-II, HCS-2 and HeLa cells. The luciferase reporter assay of the NRP2 3′-untranslated region revealed the direct regulation of NRP2 by miR-331-3p. Gene expression analyses using quantitative RT-PCR in SKG-II, HCS-2, and HeLa cells overexpressing miR-331-3p or suppressing NRP2 revealed down-regulation of E6, E7, and p63 mRNA and up-regulation of IVL mRNA. Moreover, miR-331-3p overexpression was suppressed NRP2 expression in protein level. We showed that miR-331-3p and NRP2 were key effectors of cell proliferation by regulating the cell cycle, apoptosis. NRP-2 also regulates the expression of E6/E7 and keratinocyte differentiation markers. Our findings suggest that miR-331-3p has an important role in regulating cervical cancer cell proliferation, and that miR-331-3p may contribute to keratinocyte differentiation through NRP2 suppression. miR-331-3p and NRP2 may contribute to anti-cancer effects.
Major Ampullate Spider Silk with Indistinguishable Spidroin Dope Conformations Leads to Different Fiber Molecular Structures
Authors: Dionne Justine , Lefèvre Thierry , Auger Michèle
Published: August 2016

To plentifully benefit from its properties (mechanical, optical, biological) and its potential to manufacture green materials, the structure of spider silk has to be known accurately. To this aim, the major ampullate (MA) silk of Araneus diadematus (AD) and Nephila clavipes (NC) has been compared quantitatively in the liquid and fiber states using Raman spectromicroscopy. The data show that the spidroin conformations of the two dopes are indistinguishable despite their specific amino acid composition. This result suggests that GlyGlyX and GlyProGlyXX amino acid motifs (X = Leu, Glu, Tyr, Ser, etc.) are conformationally equivalent due to the chain flexibility in the aqueous environment. Species-related sequence specificity is expressed more extensively in the fiber: the β-sheet content is lower and width of the orientation distribution of the carbonyl groups is broader for AD (29% and 58°, respectively) as compared to NC (37% and 51°, respectively). β-Sheet content values are close to the proportion of polyalanine segments, suggesting that β-sheet formation is mainly dictated by the spidroin sequence. The extent of molecular alignment seems to be related to the presence of proline (Pro) that may decrease conformational flexibility and inhibit chain extension and alignment upon drawing. It appears that besides the presence of Pro, secondary structure and molecular orientation contribute to the different mechanical properties of MA threads.
Mirabolides A and B; New Cytotoxic Glycerides from the Red Sea Sponge Theonella mirabilis
Authors: Abou-Hussein Dina , Youssef Diaa
Published: August 2016

As a part of our continuing work to find out bioactive lead molecules from marine invertebrates, the CHCl3 fraction of the organic extract of the Red Sea sponge Theonella mirabilis showed cytotoxic activity in our primary screen. Bioassay-guided purification of the active fractions of the sponge’s extract resulted in the isolation of two new glycerides, mirabolides A and B (1 and 2), together with the reported 4-methylene sterols, conicasterol (3) and swinhosterol B (4). The structures of the compounds were assigned by interpretation of their 1D (1H, 13C), 2D (COSY, HSQC, HMBC, ROESY) NMR spectral data and high-resolution mass determinations. Compounds 1–4 displayed marked cytotoxic activity against human breast adenocarcinoma cell line (MCF-7) with IC50 values of 16.4, 5.18, 6.23 and 3.0 μg/mL, respectively, compared to 5.4 μg/mL observed by doxorubicin as reference drug.
Chemo-Enzymatic Synthesis of Perfluoroalkyl-Functionalized Dendronized Polymers as Cyto-Compatible Nanocarriers for Drug Delivery Applications
Authors: Parshad Badri , Kumari Meena , Achazi Katharina , Bӧttcher Christoph , Haag Rainer , Sharma Sunil
Published: August 2016

Among amphiphilic polymers with diverse skeletons, fluorinated architectures have attracted significant attention due to their unique property of segregation and self-assembly into discrete supramolecular entities. Herein, we have synthesized amphiphilic copolymers by grafting hydrophobic alkyl/perfluoroalkyl chains and hydrophilic polyglycerol [G2.0] dendrons onto a co-polymer scaffold, which itself was prepared by enzymatic polymerization of poly[ethylene glycol bis(carboxymethyl) ether]diethylester and 2-azidopropan-1,3-diol. The resulting fluorinated polymers and their alkyl chain analogs were then compared in terms of their supramolecular aggregation behavior, solubilization capacity, transport potential, and release profile using curcumin and dexamethasone drugs. The study of the release profile of encapsulated curcumin incubated with/without a hydrolase enzyme Candida antarctica lipase (CAL-B) suggested that the drug is better stabilized in perfluoroalkyl chain grafted polymeric nanostructures in the absence of enzyme for up to 12 days as compared to its alkyl chain analogs. Although both the fluorinated as well as non-fluorinated systems showed up to 90% release of curcumin in 12 days when incubated with lipase, a comparatively faster release was observed in the fluorinated polymers. Cell viability of HeLa cells up to 95% in aqueous solution of fluorinated polymers (100 μg/mL) demonstrated their excellent cyto-compatibility.
Bio-Inspired Vision-Based Leader-Follower Formation Flying in the Presence of Delays
Authors: Oyekan John
Published: August 2016

Flocking starlings at dusk are known for the mesmerizing and intricate shapes they generate, as well as how fluid these shapes change. They seem to do this effortlessly. Real-life vision-based flocking has not been achieved in micro-UAVs (micro Unmanned Aerial Vehicles) to date. Towards this goal, we make three contributions in this paper: (i) we used a computational approach to develop a bio-inspired architecture for vision-based Leader-Follower formation flying on two micro-UAVs. We believe that the minimal computational cost of the resulting algorithm makes it suitable for object detection and tracking during high-speed flocking; (ii) we show that provided delays in the control loop of a micro-UAV are below a critical value, Kalman filter-based estimation algorithms are not required to achieve Leader-Follower formation flying; (iii) unlike previous approaches, we do not use external observers, such as GPS signals or synchronized communication with flock members. These three contributions could be useful in achieving vision-based flocking in GPS-denied environments on computationally-limited agents.
A Climate Change Vulnerability Index and Case Study in a Brazilian Coastal City
Authors: Zanetti Vitor , De Sousa Junior Wilson , De Freitas Débora
Published: August 2016

Coastal areas are highly susceptible to the effects of climate change, particularly to sea-level rise and extreme rainfall events, resulting in increased social and environmental vulnerabilities. In this context, the need for predictive planning instruments, especially in densely populated coastal areas, is a critical management priority. A number of indexes has been developed to assess coastal vulnerability. However, coastal vulnerability indexes are yet to simultaneously consider inland (e.g., landslides and flooding) and ocean (sea-level rise and coastal erosion) hazards in conjunction. To help fill this gap, we developed the Socio-Environmental Vulnerability Index for Coastal Areas. The proposed index is a diagnostic tool to assess the socio-environmental vulnerability of coastal regions in the context of climate change. Applied to the city of Santos, a coastal municipality in São Paulo state, Brazil, the index revealed that most of the city are in areas highly vulnerable to sea-level rise and floods related to extreme rainfall events. Findings show that, in fact, approximately 70% of the area of Santos (27.5 km2) consists of high vulnerability areas mostly located close to urban drainage channels, residential, and other built-in areas. Another 0.12% (0.05 km2) were classified as very high vulnerability areas compromising port and industrial infrastructure. These results highlights the susceptibility of the urban insular area of Santos to climatic change hazards. This study might prove relevant to support local decision-makers in preparing adaptation plans and responding to climate-related risks in vulnerable coastal cities.
Criminality and election outcomes in Nigeria
Authors: Suleiman Barnabas
Published: August 2016

This study explores democratic practice in Nigeria’s Fourth Republic in the light of globally prescribed and acceptable norms, tenets and values of democracy as a form of government. The study was conducted in Nigeria and adopted a multistage sampling technique to administer questionnaire to 700 delegates across the six (6) geopolitical zones of Nigeria’s 36 States. The results and findings show that Nigeria’s democracy is plagued with massive electoral fraud, including intimidation, disenfranchisement of eligible contestants and voters from participating in the democratic process, corruption of the election process, scam, and fraudulent declaration of winners of elections. The implications of such democratic deceit in Nigeria’s democracy includes voter apathy resulting from lack of confidence in the democratic process and outcome, violence and political instability and the nonparticipation of qualified and honest  citizens in the politics of Nigeria. Consequently, leaders that emerge from Nigeria’s democratic politics are not always the choice of the people, which explains why they are not accountable to the people as well as why there is deficit of public trust in Nigeria’s democratic system.
Sistema nacional de aprendizado: a mudança econômica em economias retardatárias
Authors: Prizon Ivan , Pereira Adriano José
Published: August 2016

Este artigo trata de como a evolução das Tecnologias Sociais (TS) em um ambiente institucional pode reduzir o hiato tecnológico entre os países industrializado e de industrialização tardia. As TS’s são relações organizacionais que moldam e são moldadas pelas instituições e que através do processo de aprendizado podem levar a um aumento da capacidade de absorção tecnológica. O conceito de Sistema Nacional de Aprendizado (SNA) é referenciado para compreensão da dinâmica dos atores sociais e sua trajetória de desenvolvimento individual e coletivo. O artigo utiliza-se das abordagens institucionalista e evolucionária como forma de correlacionar a mudança técnica e institucional, considerando-as como fator fundamental para o desenvolvimento capitalista, a partir de processos inovativos. A perspectiva de economias retardatárias é importante para a compreensão da não estaticidade econômica dos países e tendo assim a diminuição do hiato tecnológico como algo passível de ser atingido.
Venture capital e inovação: uma análise a partir das startups de biocombustíveis dos Estados Unidos
Authors: Françoso Mariane Santos , De Queiroz Sérgio Robles Reis
Published: August 2016

O presente trabalho tem como objetivo mostrar a importância do venture capital para o surgimento de novas empresas de alta tecnologia, tomando o exemplo das startups de biocombustível nos Estados Unidos, país com o sistema de venture capital considerado o mais desenvolvido do mundo. Através de revisão bibliográfica e análise de redes foi possível perceber que o venture capital tem participação intensa nessas empresas, caracterizando-se como uma importante fonte de financiamento.
Five Years Later: An Update on the Status of Collections of Endemic Gulf of Mexico Fishes Put at Risk by the 2010 Oil Spill
Authors: Chakrabarty Prosanta , O’Neill Glynn , Hardy Brannon , Ballengee Brandon
Published: August 2016

The 2010 Gulf of Mexico Oil Spill took place over 180,000 square kilometers during a 12-week period over five years ago; however, this event continues to influence the development and distribution of organisms in and around the region of the disaster. Here we examine fish species that may have been most affected by noting their past distribution in the region of the spill and examining data of known collecting events over the last 10 years (five years prior to the spill, five years post spill).

We found that more than half of the endemic fish species of the Gulf (45 of 77)
Intravitreal Bevacizumab for Zone II Retinopathy of Prematurity
Authors: Larrañaga-Fragoso Paula , Peralta Jesús , Bravo-Ljubetic Luciano , Pastora Natalia , Abelairas-Gómez José
Published: August 2016

Purpose:

To evaluate the treatment outcomes of intravitreal bevacizumab injections as monotherapy in type 1 retinopathy of prematurity (ROP).

Methods:

A retrospective chart review was performed for patients with type 1 ROP who had intravitreal bevacizumab injections between November 2013 and January 2015 at La Paz University Hospital in Madrid, Spain. Gestational age at birth, birth weight, sex, ROP zone, ROP stage, mean age at treatment, and follow-up period were recorded. The final clinical status of the retina was noted for each patient. The primary outcome measures included ROP recurrences requiring re-treatment, complete or incomplete peripheral vascularization, mean age at complete vascularization, and refractive errors.

Results:

From 14 patients enrolled with type 1 ROP, 28 eyes were included. The mean gestational age at birth was 25.9 ± 2.34 weeks (range: 23.6 to 32.4 weeks) and the median birth weight was 694 g (range: 487 to 1,740 g). All eyes showed zone II ROP: 18 eyes (64.3%) had anterior zone II ROP and 10 eyes (35.7%) had posterior zone II ROP. One week after intravitreal bevacizumab injection, 14 eyes (50%) had achieved complete regression of ROP, and a partial regression of ROP was observed in 10 eyes (35.7%). Twenty-two eyes (78.6%) obtained complete vascularization during the follow-up. The median time to complete vascularization was 134 ± 21.45 days. The mean spherical equivalent at last visit was 1.99 diopters.

Conclusions:

Intravitreal bevacizumab injection used as a monotherapy is an effective treatment approach in patients with zone II ROP.

[
J Pediatr Ophthalmol Strabismus
. 2016;53(6):375–382.]
Optic Gliomas in Neurofibromatosis Type 1
Authors: Parkhurst Emily , Abboy Sridevi
Published: August 2016

Purpose:

To examine the incidence, presentation, and outcome of optic gliomas in children with neurofibromatosis type 1 (NF1) in Southern California Kaiser Permanente.

Methods:

The authors queried the Southern California Kaiser Permanente electronic medical record database to find patients diagnosed as having NF1. Genetics, ophthalmology, and imaging medical records of patients with optic glioma were reviewed.

Results:

A total of 708 patients younger than 21 years had a diagnosis of NF1 in Southern California Kaiser Permanente and 30 (4.2%) had a diagnosis of optic glioma. The average age of diagnosis was 5 years, with a range of 18 months to 12 years. Half (15 of 30) of the patients diagnosed as having optic glioma presented with symptoms (eg, vision loss, proptosis, and precocious puberty). Eight of 15 of the symptomatic patients were treated with surgery and/or chemotherapy. Symptomatic children were diagnosed later than those diagnosed through routine screening (5.7 vs 3.9 years old). The oldest child presented with symptoms at age 12 years. One asymptomatic patient had prophylactic chemotherapy. Sixty-three percent (19 of 30) of the gliomas were bilateral, 23% (7 of 30) were right-sided, and 13% (4 of 30) were left-sided. Fifty-three percent (17 of 30) of the gliomas involved the optic chiasm.

Conclusions:

Screening practices for optic glioma are inconsistent. Most children with NF1 at risk for optic glioma do not have even one visit with an ophthalmologist. Children with NF1 can develop asymptomatic optic glioma as early as age 1 year. Annual ophthalmologic examination and screening for precocious puberty in children with NF1 is important for early diagnosis of optic gliomas and may reduce morbidity.

[
J Pediatr Ophthalmol Strabismus
. 2016;53(6):334–338.]
Residencia San Pedro, California
Authors: Neutra Richard J. , Fisher Benno , Koschin Serge , Blanton John
Published: August 2016

Esta vivienda representa una aproximación más hacia la típica casa grande española, con techos de teca de 7 cm, que los señores Rados han edificado y en la que albergan a su gran familia de hijos, los cuales tienen ya sus propios vástagos. Ambos, el señor y la señora Rados, descienden de familias navieras italianas de Trieste, y el propio señor Rados tiene una compañía constructora de barcos en el puerto de San Pedro, que puede verse desde su propia casa. Los dos son verdaderamente unos abuelos muy sociables, cariñosos y atentos. Por añadidura, la señora Rados se entretiene frecuentemente y le agrada el cuidado de la casa. Por ello ha sido proyectada para facilitar sensiblemente toda esta serie de actividades.
Convento de La Tourette
Authors: Editorial Equipo
Published: August 2016

Situado en Aveux-sur-Arbresle, cerca de Lyon, el convento ocupa la cima de un pequeño montículo frente a un valle y con vistas al ondulado paisaje de la campiña lionesa.
Edificio administrativo Nestlé, en Vevey
Authors: Tschumi Jean
Published: August 2016

La casa Nestlé ha levantado —para centralizar su aparato administrativo— un soberbio edificio en Vevey (Suiza), haciendo gala de unas premisas admirables: elección cuidadísima del emplazamiento, perfecto diseño, empleo de materiales nobles y esmerada ejecución. Era, pues, necesario que se obtuviera un resultado correspondiente, una obra maestra de gran belleza y perfecto funcionamiento.
Nueva York. Centro deportivo y recreativo
Authors: Luckman Charles
Published: August 2016

Charles Luckman Asociados, oficina de proyectos de Los Angeles y Nueva York, ha recibido el encargo de proyectar un centro deportivo y recreativo, con presupuesto de 38 millones de dólares, por parte del Almirante John J. Bergen y de Irving Mitchell Felt, presidente y director, respectivamente, de la Graham-Paige Corporation, propietaria del Madison Square Garden.
David B. Steinman
Authors: Editorial Equipo
Published: August 2016

El doctor ingeniero David B. Steinman, diseñador de más de cuatrocientos puentes en todo el mundo, ha fallecido en Nueva York, a los setenta y tres años de edad. Como homenaje a su memoria, y en agradecimiento a sus frecuentes colaboraciones en nuestra revista, “Informes de la Construcción” le dedica este cálido recuerdo.
Museo Nacional, en Accra, Ghana
Authors: Drake y Lasdun Arquitectos
Published: August 2016

El edificio, de indudable efecto plástico con su escueto diseño y esmerada realización, se adapta, fundamentalmente — y en esto consiste la utilidad y funcionalismo, base de la belleza—, a las condiciones topográficas y climáticas de la región, y a la finalidad para la que fue construido, expresando su fisonomía exterior el contenido y el uso a que se destina.
Cubierta colgada en la piscina municipal de Wuppertal
Authors: Leonhardt Fritz , Andra Wolfhart
Published: August 2016

La gran piscina municipal de Wuppertal (Alemania), de forma en T, presenta una superficie de 40 x 65 en planta. Para cubrir esta superficie se pensó, en principio, en cubrirla con una lámina ondulada, de hormigón, de generatrices según la mínima dimensión de su proyección.
B. C. Electric Building. Vancouver - Canadá
Authors: Thompson, Berwick y Pratt Arquitectos
Published: August 2016

Este edificio está destinado a albergar las oficinas de una empresa oficial, la B. C. Electric, con objeto de centralizar todos los servicios, administración y relaciones con el público. El gran número de empleados —un millar— pueden así estar reunidos en un solo edificio, con lo que se facilitan las interrelaciones y se consigue máxima rapidez y economía.
Dos nuevos puentes ligeros, en Alemania
Authors: Bay Hermann
Published: August 2016

Las dos obras, objeto de ligera descripción en este trabajo, dan patentes muestras de las direcciones generales en el orden constructivo hacia la belleza, esbeltez y función específica, objeto éste, que ha de cubrir las exigencias de la explotación pública, en este caso, de la obra.
Acabado de un firme de hormigón
Authors: Rocci Sandro Rocci
Published: August 2016

Supongamos que el hormigón fresco acaba de sufrir la última pasada de la máquina extendedora, vibradora. Lo principal está hecho ya; pero quedan una serie de pequeñas y algo enojosas, pero importantísimas, operaciones de acabado, que son las que marcan la diferencia entre el éxito y el fracaso más o menos encubierto de todas las costosas operaciones que han sido ya realizadas. El ejecutar con buen criterio y cierto cuidado estos detalles corona la empresa. A todo lo largo de su historia ha venido quedando claro que el firme de hormigón es una obra que requiere buen sentido al proyectar y una ejecución esmerada; sólo estos dos factores, especialmente el segundo, pueden garantizar el éxito de la construcción.
Embajada de U. S. A., La Haya
Authors: Breuer M.
Published: August 2016

Tres extremos o premisas fundamentales había que tener en cuenta al proyectar este edificio —su emplazamiento, la ciudad en que iba a construirse y los factores históricos que la rodean—, los cuales han de ser estudiados con esmero al proyectar un edificio cualquiera y deben ser punto de partida para conformar su fisonomía, textura y volumetría, pero todos ellos se acusan más pronunciadamente en el caso de un edificio oficial y en el de una ciudad tradicionalmente sede del Gobierno holandés.
Vivienda unifamiliar, Chicago
Authors: Mazer Richard , Rosner Lawrence M.
Published: August 2016

Este edificio fue proyectado para un contratista de casas. Él lo quería funcional, adaptado a las costumbres de vivir de su familia y debía ser el prototipo de las casas que él quería construir en el futuro para su clientela. Su arquitecto propuso una casa con muchos conceptos modernos y progresivos que se adaptaría fácilmente en una ciudad, pero quedaría dentro de los medios económicos de una familia normal. El resultado fue que el arquitecto, junto con el contratista, construyeron muchas casas parecidas en Chicago y sus alrededores.
Vivienda unifamiliar en Las Matas
Authors: García Benito M.
Published: August 2016

En las proximidades de Madrid, en el término de Las Rozas, y en una parcela de unos 1.000 m2, con pendiente acusada hacia el mediodía, se ha construido esta graciosa vivienda, adoptando, en su emplazamiento y planta, soluciones ambas acertadas y funcionales, de acuerdo con la orientación y el relieve del terreno. Dada la necesidad de aprovechar al máximo el solar, y con la idea de dejar una zona de jardín lo más amplia posible, se ha ceñido la vivienda, cuanto está permitido, a la medianería norte, dejando la parte más noble de la residencia (salón y dormitorios) mirando al sur, a la zona ajardinada y de piscina.
Edificio para oficinas en Hartford, Estados Unidos
Authors: Sherwood, Mills y Smith Arquitectos
Published: August 2016

Este edificio ha obtenido el primer premio del Instituto Americano de Arquitectos, en 1960, y el Certificado de Mérito para un proyecto destacado, en 1959, de la Asociación de Arquitectos de Nueva York.
Iglesia del Redentor, en Turín, Italia
Authors: Mosso Nicola , Mosso Leonardo , Norzi Livio
Published: August 2016

Hace unos años, y junto a otros colegas del Instituto Nacional de Urbanismo, estudié un plano regulador del pueblo de Miraflori, en Turin, planificación que posteriormente ha sido considerada en las oficinas técnicas municipales. El conjunto o complejo constructivo comprendía una serie de edificios públicos, entre los que era de rigor prever un centro parroquial que satisficiera las necesidades lógicas de los trece mil habitantes que componen el poblado, adyacente al gran núcleo industrial de la Fiat Miraflori.
Vivienda unifamiliar. Feldmeilen, Suiza
Authors: Breuer Marcel , Beckhard Herbert , Eidenbenz Eberhard
Published: August 2016

Aún antes de conocer la identidad del arquitecto autor de esta magnífica residencia podemos asimilarla a su acusada personalidad, por los rasgos característicos de su estilo peculiar, por su configuración en planta, alzados y tratamiento.
Algunas presas de tierra en Francia
Authors: Vié Georges
Published: August 2016

La presa adosada al dique, llamada de Serre de Monge, donde se ha instalado la Central subterránea, tiene 600 m de longitud en coronación, embalsa 1.200 millones de metros cúbicos. La Central dispone de cuatro grupos Francis, de 90.000 KVA de potencia, que utilizará un caudal de 300 m/s con un salto hidrostático de 107 metros.
Palacio ENI, Italia
Authors: Nizzoli y Oliveri Arquitectos
Published: August 2016

El palacio de la Sociedad Nacional de Hidrocarburos se levanta muy próximo a la vía Emilia, sobre un solar de 20.000 m2, ocupando casi 3.000 m2 la superficie cubierta. La parte libre de terreno ha sido dedicada a pistas de acceso, estacionamiento, zonas verdes y edificio destinado a biblioteca.
Puentes para carretera en Serre-Ponçon
Authors: Courbon J.
Published: August 2016

En el Departamento de los Altos Alpes (Francia) se ha proyectado levantar una presa de cierre sobre el rio Durance en una zona denominada Serre-Ponçon. La construcción de esta presa crea un remanso de unos 20 kilómetros de longitud que ha obligado a modificar los trazados de la línea férrea y varias carreteras cuyas plataformas se hallaban en zonas inundables por el referido remanso.
Reconstrucción de los puentes de Chalonnes
Authors: Delcamp A.
Published: August 2016

Los puentes de la carretera general núm. 161 bis, tronco de la circulación entre norte y sur del Departamento de Main et Loire (Francia), salvan el rio Loire a unos 20 km al oeste de Angers formando tres estructuras diferentes, una para cada brazo del río, que, desde 1841 a 1940, han estado en servicio, si bien con una carga máxima para vehículos de 8,4 toneladas.
Grandes remolques
Authors: Editorial Equipo
Published: August 2016

El empleo creciente del material pesado auxiliar en la construcción de obras de ingeniería civil ha motivado la fabricación de grandes plataformas, capaces de transportar toda clase de maquinaria auxiliar. En general, este tipo de maquinaria requiere medios de transporte, pues su circulación por carreteras es lenta, obstructiva y cara, siempre que se trate de grandes distancias, caso presente en la mayoría de ocasiones en que se exige un traslado de esta maquinaria de una a otra obra.
Edificio de oficinas
Authors: Y asociados Gollins, Melvin, Ward
Published: August 2016

Este edificio, que servirá de sede a la casa «Castrol», es un imponente y a la vez grácil edificio y se levanta entre la calle Balcombe, la plaza Gloucester y la avenida Marylebone. Está constituido por un amplio cuerpo bajo que ocupa la totalidad del solar y que se eleva en dos y tres plantas, con limpia y escueta portada de acceso de cuidadas pero simplicísimas líneas.
Edificio de oficinas Kaiser Center
Authors: Becket Welton
Published: August 2016

El nuevo edificio de 28 plantas del Centro Kaiser reúne la sede central de esta gran organización industrial, que tiene más de cincuenta filiales, distribuidas en diversas facetas de la industria: aluminio, minerales, cemento, productos químicos, yeso... Aquí se centra la dirección y las oficinas generales de la empresa.
Iglesia de San Jacobo, Anger
Authors: Haindl F. F.
Published: August 2016

Se trata de una iglesia destinada al uso doble de los fieles en general, y particularmente formando parte del monasterio de las Hermanas de la Caridad, de Anger. Está prevista para una capacidad de quinientos feligreses sentados (alumnos y visitantes),en la planta baja, y un oratorio posterior, en la primera planta, con posibilidad de albergar a 220 hermanas. Los asientos están dispuestos de forma gradual, con objeto de facilitar la vista hacia el altar desde todos los puntos; en este oratorio se prevé también un altar.
La tribuna del hipódromo Yonkers
Authors: Feld Jacob , Levy Lionel K.
Published: August 2016

La reforma del hipódromo Yonkers, de Nueva York, dedicado a las carreras de caballos de trote, a cuyas reuniones nocturnas suelen concurrir de 15 a 35.000 espectadores, se ha verificado siguiendo un programa desarrollado entre el tiempo muerto y las temporadas de actividad. Rodeado de otras edificaciones, el único espacio que se podía disponer era el ganado en el sentido vertical. Todo se encaminó, en primer lugar, hacia un acceso fácil y zonas cómodas de estacionamiento de vehículos.
Colegio en Costa-Mesa, California
Authors: Neutra Richard J. , Alexander R.
Published: August 2016

Un edificio científico en un Centro de enseñanza, un lugar destinado a enseñar y aprender principios básicos y fundamentales del saber humano; a educar el pensamiento en la técnica de la observación sistemática, de acuerdo con las últimas ideas y con la información más reciente. Todo este cúmulo de detalles, y algo todavía más complejo, debe representar un Centro de educación científica, expresando neta y claramente su misión, a la sola observación del conjunto construido. Realmente, es ésta una condición que debería ser inherente a cualquier obra arquitectónica: transparentar, por su forma y tratamiento, el contenido y función del edificio.
Vivienda unifamiliar, Andover (Massachusetts)
Authors: Breuer Marcel
Published: August 2016

Esta casa de campo, situada en Andover —Massachusetts, U. S. A.—, contiene todas las características distintivas de la arquitectura de Breuer; es decir: nitidez, organigrama perfecto, utilización sabia de los materiales, adaptación al paisaje, simplicidad de líneas y estudiada modulación que proporciona los volúmenes y la distribución en planta.
Edificio Tavaro, Ginebra
Authors: Addor y Julliard Georges
Published: August 2016

El edificio se ha construido con fines administrativos, con objeto de agrupar las oficinas y zonas de recepción, de la fábrica de máquinas de coser "Elna". Mediante la distribución en planta y en sentido netamente longitudinal, a lo largo de la carretera Chatelaine y con retranqueo respecto de esta vía de gran tráfico y ruido, así como previendo un gran espacio verde entre esta pantalla constructiva de líneas modernas y la fábrica, situada al fondo .del solar, se ha conseguido aislar las oficinas de ambas zonas ruidosas.
Estudio sobre un bordillo encauzador para carretera
Authors: Rocci Sandro , Holenweg Peter
Published: August 2016

La utilidad de un bordillo prefabricado resulta bien evidente. Puede cumplir las funciones de: limitador lateral del firme, fácil reposición, evitar el deterioro de los márgenes, y, convenientemente dispuesto, constituir un eficaz balizamiento nocturno de la carretera. Puede, ademáa, utilizarse como encofrado para construir la banda exterior del firme.
Centrales térmicas a pie de mina
Authors: Seshadri B.
Published: August 2016

Ligera descripción de la gran cuenca hullera de carbón pardo, de Victoria (Australia). Esta inmensa cuenca carbonífera está situada a unos 150 km de Melbourne, estado de Victoria, y en la región denominada el Valle del río Latrobe. Se cree que esta cuenca es la mayor del mundo en su género. Estos yacimientos se extienden en una longitud de unos 65 km y una anchura que varía de 8 a 16 km. En un cierto lugar de esta zona, y a unos 27 m de profundidad, se ha perforado una capa de unos 330 m de potencia, lo que, innegablemente, hace de ella la mayor del mundo. Al crearse en 1919 la Comisión Nacional de Electricidad, se previó la construcción de la primera Central a pie de mina para el año 1923, con una capacidad inicial de 50.000 kW de potencia.
Estudio de los fenómenos de fluencia en sistemas posteriormente modificados
Authors: Johannson Johannes
Published: August 2016

La fluencia es la deformación plástica que tiene lugar en una pieza de hormigón, debido a las solicitaciones por compresión. Freyssinet fue el primero que desarrolló una teoría de la fluencia, de extraordinaria importancia en las estructuras de hormigón pretensado. Terzaghi ideó un modelo en el que se puede explicar muy bien el proceso físico que se realiza en el hormigón, el cual conduce a la deformación plástica.
Hombre, calor y aislamiento
Authors: Neutra Richard J.
Published: August 2016

Con los nuevos tipos estructurales y con los adelantos de las ciencias biológicas en lo que se refiere a los procesos orgánicos, mis ideas sobre aislamiento, y las de casi todos los demás arquitectos y constructores, han sufrido una evolución interesantísima en los últimos veinticinco años. Y me complace subrayar que los que, como yo, estudiamos el decorado humano, podemos hacer mucho en beneficio de nuestros clientes. No hace aún mucho tiempo toda la protección de una casa contra el peligro de transferencia térmica se confiaba exclusivamente a muros y cubiertas no aislantes. Los propietarios se limitaban a culpar al tiempo de su falta de confort. Pero esta falta de comodidad en cuanto a calefacción no era la única consecuencia; tras ella aparecían daños de efectos duraderos y patológicos.
Primera iglesia congregacional
Authors: Blessing Wilfred E.
Published: August 2016

La primera iglesia congregacional que se construía en Sunnyvale (California) había de ser estudiada con extraordinario cuidado, para que expresara, por sí misma, la verdadera integridad espiritual y de función para que era creada.
Iglesia episcopal de San Agustín, Indiana
Authors: Dart Edward D.
Published: August 2016

Una congregación episcopal de Gary —ciudad industrial del acero en el Estado de Indiana— ha construido esta modesta iglesia que, sin duda, se aparta de la línea tradicional arquitectónica recta y severa para adoptar formas nuevas, originales y gratas que aporten ideas innovadoras y marquen nuevas directrices a las construcciones de nuestro tiempo.
El suelo estabilizado, material de construcción
Authors: Nadal Jaime
Published: August 2016

Desde el momento en que se comprobó que, mediante determinados tratamientos, era posible mejorar la calidad de un suelo haciéndolo más resistente, más impermeable y más duradero, el suelo pasó a constituir lo que se llama un material de construcción. Los orígenes de este material se pierden en la lejanía del tiempo, habiéndosele dado múltiples usos, algunos de los cuales han evolucionado en tal forma, que hoy resulta ya difícil reconocer en ciertos objetos su antecesor —suelo estabilizado— e, incluso, escapan del grupo de lo que, actualmente, cabe considerar bajo la denominación genérica que encabeza estas líneas.
Gettysburg: Monumento al mundo libre
Authors: Neutra Richard J.
Published: August 2016

En el verano del año 1958 fui invitado, por las autoridades de la Universidad de Arizona, en Tucson, a la colocación de la primera piedra de su futuro taller, construido para favorecer el desarrollo técnico del Estado. Varios alcaldes y ministros presenciaron la ceremonia, que fue muy interesante, y uno de los periodistas presentes, John Riddick, del "Tucson Daily Citizen", invitó cordialmente, a mi esposa y a mí, a atravesar, al día siguiente, la frontera mejicana, que cruzaba un vasto desierto.
Aeropuerto internacional de Roma
Authors: Luccichenti - , Monaco - , Morandi - , Zavitteri -
Published: August 2016

No disponible
Grúa para obras de gran altura
Authors: Hochtief AG
Published: August 2016

En las construcciones modernas donde las estructuras se extienden predominantemente en altura, caso corriente en los llamados rascacielos, entre los elementos auxiliares de obra se encuentra, en primer lugar, la grúa.
Flipping First-Year English
Authors: Prodoehl Dana Edwards
Published: August 2016

This chapter discusses the development, implementation, and assessment of an online module that addresses argument writing for First-Year English classes at University of Wisconsin – Whitewater. The author offers a blueprint for the development of online modules—from planning and funding to implementation and assessment—in order to offer new approaches to the flipped or inverted classroom that may be of particular interest to courses in the Humanities, specifically English. The chapter also offers advice and best practices for instructors interested in developing such modules in order to supplement student learning and create more effective conferencing strategies.
Fostering Collaborative Learning with Mobile Web 2.0 in Semi-Formal Settings
Authors: Mwanza-Simwami Daisy
Published: August 2016

Mobile Web 2.0 technologies such as: mobile apps, social networking sites and video sharing sites have become essential drivers for shaping daily activities and meeting learning needs in various settings. However, very few studies link mobile Web 2.0 to supporting collaborative learning in real-life problem solving activities in semi-formal contexts. A study of collaborative learning and mobile Web 2.0 usage practices in real-life problem solving activities was carried out with 18 participants recruited from a local faith based community club. Research data was gathered through observational studies, open-ended questionnaires, semi-structured interviews and by logging content captured on mobile devices. Data analysis examined learner demographics, social interactions and artefacts produced in activities. Results indicate that the choice and use of mobile Web 2.0 to support collaborative learning in semi-formal settings is based on the ways in which technological functions effectively support and enhance established social relations and practices.
The i2Flex Methodology
Authors: Avgerinou Maria D. , Gialamas Stefanos P.
Published: August 2016

This chapter begins with a brief overview of blended learning in the K-12 in order to provide the theoretical framework for the i2Flex methodology and ground it on the larger educational landscape of the early 21st Century. The background, definition, and praxis of the methodology are then presented, followed by the conditions that are critical to its success. Specific reference is made to perspectives, instruments and processes that have served as pillars and guides for i2Flex, such as Boyer's scholarship of teaching (1990), TPACK (Mishra & Koehler, 2006), the Community of Inquiry (CoI) Framework (Garrison, et al., 2000), and the Quality Matters® course design standards and rubric.
Innovative Instruction in STEM Education
Authors: Coyle Victoria C. , Newman Dianna L. , Connor Kenneth A.
Published: August 2016

Research from the learning sciences provides evidence that students engaged in collaborative learning in authentic activities are better able to retain and transfer knowledge to alternate contexts leading educators to reexamine the role of the lecture as a dominant instructional method. The use of alternate classroom structures to create student-centered learning environments is appropriate in STEM education. This chapter presents the development of a flipped classroom in a higher education STEM course, and describes the iterative process and subsequent structure of the course over several years. Considerations when implementing a flipped model of instruction are: the degree of self-regulation required of students, methods of assessment and the relationship between online information and authentic activities that students participate in during class. Recommendations for future research directions are discussed.
Teaching Strategies and Tactics in K-12 Blended Education
Authors: Katz Anne , Kim Jackie Hee-Young
Published: August 2016

With a mission of creating a new paradigm of instructional methods to increase engagement in student learning in order to help develop more resilient students in a high-needs school district, this study examined implementation of the flipped classroom model in an early childhood and childhood education setting. This chapter will start by locating challenges in the current K-12 educational field. It will then examine how flipped classroom model approaches will simultaneously help educators meet long-standing challenges and support teachers to meet the diverse needs of students. This chapter will further discuss a pedagogical rationale for the flipped classroom model. It will then proceed to showcase best practices in utilizing the Flipped Classroom (FC) Model through the presentation of multiple teacher case studies. Lastly, this chapter will discuss considerations that should be examined while executing the Flipped Classroom model.
Applying the Polysynchronous Learning to Foster the Student-Centered Learning in the Higher Education Context
Authors: Ouyang Fan
Published: August 2016

Teaching and learning computer programming has posed great challenges for both instructors and students. An emerging blended learning mode - polysynchronous learning has potentials to motivate and engage students in the programming learning process, to optimize students' programming learning experiences, and to transform the computer programming teaching and learning. This paper aims to integrate the polysynchronous learning, as a communication model, with the student-centered learning, as a pedagogical approach, to design a graduate-level course - App Design and Development. The authors primarily focuses on describing my decision-making process of the physical environment design, the technologies and tools selection, and the polysynchronous learning activity design, as well as specific details regarding these three aspects. Moreover, potentials, challenges, and implications of applying the polysynchronous learning to foster the student-centered learning in the higher education context are discussed.
Guidelines for Design and Implementation of Mobile Learning
Authors: Ally Mohamed , Samaka Mohammed
Published: August 2016

As technology evolves, there is a shift towards the use of mobile technology to deliver education both on-campus in a blended format and online delivery. This shift is moving at a very fast pace which is a major challenge for educational organizations which has to train staff and build the infrastructure for mobile delivery. Educators have to be trained on how to develop quality mobile learning materials, how to use the technology for the delivery, and how to provide quality support to students so that they are successful when using mobile technology to learn. This chapter provides guidelines for designing and implementing mobile learning.
Instructional Re-design for an Active Flipped Classroom
Authors: Hosler Kim A.
Published: August 2016

The purpose of this chapter is to present and discuss the instructional design process model -- ADDIE, and nine flipped course design principles, which when used in parallel, offer a means to support the development and implementation of a hybrid or flipped classroom. Discussion of the pedagogical terms hybrid, blended, flipped classrooms, and active learning, are followed by an overview of the instructional design process model ADDIE, along with evidenced-based flipped classroom design principles. A partial example of how these two frameworks may be applied to the re-design of a fully online course into a flipped or hybrid course is demonstrated, and emergent design-consideration questions are offered.