bluuebunny/crossref_metadata_2025 huggingface dataset:
The Gambling Factors Related with the Level of Adolescent Problem Gambler
Authors: Kang Kyonghwa , Ok Jong Sun , Kim Hyeongsu , Lee Kun-Sei
Published: June 2019

The purpose of this study was to investigate the gambling factors related with the gambling problem level of adolescents to provide basic information for the prevention of adolescent gambling problems. The data was drawn from the 2015 Survey on Youth Gambling Problems of the Korea Center on Gambling Problems for Korean students in grades 7–11 (ages 13–17 years) and included 14,011 study subjects (average age 14.9 years, 52.5% male). The lifetime gambling behavior experience was 42.1%, and 24.2% had a gambling behavior experience within the past three months. The past three-month prevalence of problem gambling was 1.1%. The gambling factors related with the level of adolescent problem gambling include the presence of nearby gambling facilities, having personal relationships with people that gamble, a higher number of experienced gambling behaviors, male adolescents, and a greater amount of time spent gambling. To the best of our knowledge, this study is the first report to identify gambling factors related with the level of adolescent problem gambling in Korean adolescents using national data. These findings suggest that gambling prevention efforts must consider not only access to individual adolescents as early intervention, but also environmental strategies such as accessibility regulations and alternative activities.
Evaluating Family Planning Organizations Under China’s Two-Child Policy in Shandong Province
Authors: Xu Lizheng , Yang Fan , Sun Jingjie , Nicholas Stephen , Wang Jian
Published: June 2019

Background: The 2015 two-child policy was the most important institutional change in China’s family planning since the 1978 one-child policy. To implement the two-child policy, China merged the former health departments and family planning departments into the new Health and Family Planning Commission organization. We collected and analyzed funding and expenditure data, providing a novel approach to assessing the family planning outcomes under China’s two-child policy. The paper shows how the management structure and funding levels and streams shifted with the new two-child policy and assesses the new management structure in terms of the ability to carry out tasks under the new family planning policy. Methods: We collected data on the funding, structure of expenditure and social compensation fee in Shandong province from 2011 to 2016, to evaluate how resources were allocated to family planning before and after the organizational change. We also collected interview data from family planning administrators. Results: While total family planning government financing was reduced after the organizational change, expenditures were shifted away from management to family planning work. Funding (80%) was allocated to the grass-root county and township levels, where family planning services were provided. The overlapping work practices, bureaucracy, and inefficiencies were curbed and information flows were improved. Conclusions: The new Health and Family Planning Commissions shifted resources to carry out the new family planning policy. The aims of the two-child policy to reduce inefficiencies, overlapping authorities and excessive management were achieved and expenditures on family planning work was enhanced and made more efficient.
Discovering Memory-Based Preferences for POI Recommendation in Location-Based Social Networks
Authors: Gan Mingxin , Gao Ling
Published: June 2019

Point-of-interest (POI) recommendations in location-based social networks (LBSNs) allow online users to discover various POIs for social activities occurring in the near future close to their current locations. Research has verified that people’s preferences regarding POIs are significantly affected by various internal and external contextual factors, which are therefore worth extensive study for POI recommendation. However, although psychological effects have also been demonstrated to be significantly correlated with an individual’s preferences, such effects have been largely ignored in previous studies on POI recommendation. For this paper, inspired by the famous memory theory in psychology, we were interested in whether memory-based preferences could be derived from users’ check-in data. Furthermore, we investigated how to incorporate these memory-based preferences into an effective POI recommendation scheme. Consequently, we refer to Ebbinghaus’s theory on memory, which describes the attenuation of an individual’s memory in the form of a forgetting curve over time. We first created a memory-based POI preference attenuation model and then adopted it to evaluate individuals’ check-ins. Next, we employed the memory-based values of check-ins to calculate the POI preference similarity between users in an LBSN. Finally, based on this memory-based preference similarity, we developed a novel POI recommendation method. We experimentally evaluated the proposed method on a real LBSN data set crawled from Foursquare. The results demonstrate that our method, which incorporates the proposed memory-based preference similarity for POI recommendation, significantly outperforms other methods. In addition, we found the best value of the parameter H in the memory-based preference model that optimizes the recommendation performance. This value of H implies that an individual’s memory usually has an effect on their daily travel choices for approximately 300 days.
Cigarette Smoke Induces the Risk of Metabolic Bone Diseases: Transforming Growth Factor Beta Signaling Impairment via Dysfunctional Primary Cilia Affects Migration, Proliferation, and Differentiation of Human Mesenchymal Stem Cells
Authors: Aspera-Werz Romina H. , Chen Tao , Ehnert Sabrina , Zhu Sheng , Fröhlich Theresa , Nussler Andreas K.
Published: June 2019

It is well established that smoking has detrimental effects on bone integrity and is a preventable risk factor for metabolic bone disorders. Following orthopedic surgeries, smokers frequently show delayed fracture healing associated with many complications, which results in prolonged hospital stays. One crucial factor responsible for fracture repair is the recruitment and differentiation of mesenchymal stem cells (MSCs) at early stages, a mechanism mediated by transforming growth factor β (TGF-β). Although it is known that smokers frequently have decreased TGF-β levels, little is known about the actual signaling occurring in these patients. We investigated the effect of cigarette smoke on TGF-β signaling in MSCs to evaluate which step in the pathway is affected by cigarette smoke extract (CSE). Single-cell-derived human mesenchymal stem cell line (SCP-1 cells) were treated with CSE concentrations associated with smoking up to 20 cigarettes a day. TGF-β signaling was analyzed using an adenovirus-based reporter assay system. Primary cilia structure and downstream TGF-β signaling modulators (Smad2, Smad3, and Smad4) were analyzed by Western blot and immunofluorescence staining. CSE exposure significantly reduced TGF-β signaling. Intriguingly, we observed that protein levels of phospho-Smad2/3 (active forms) as well as nuclear translocation of the phospho-Smad3/4 complex decreased after CSE exposure, phenomena that affected signal propagation. CSE exposure reduced the activation of TGF-β modulators under constitutive activation of TGF-β receptor type I (ALK5), evidencing that CSE affects signaling downstream of the ALK5 receptor but not the binding of the cytokine to the receptor itself. CSE-mediated TGF-β signaling impaired MSC migration, proliferation, and differentiation and ultimately affected endochondral ossification. Thus, we conclude that CSE-mediated disruption of TGF-β signaling in MSCs is partially responsible for delayed fracture healing in smokers.
Initial Harm Reduction by N-Acetylcysteine Alleviates Cartilage Degeneration after Blunt Single-Impact Cartilage Trauma in Vivo
Authors: Riegger Jana , Leucht Frank , Palm Hans-Georg , Ignatius Anita , Brenner Rolf E.
Published: June 2019

Joint injuries are highly associated with the development of post-traumatic osteoarthritis. Previous studies revealed cell- and matrix-protective effects of N-acetylcysteine (NAC) after ex vivo cartilage trauma, while chondroanabolic stimulation with bone morphogenetic protein 7 (BMP7) enhanced type II collagen (COL2) expression. Here, as a next step, we investigated the combined and individual efficacy of intra-articular antioxidative and chondroanabolic treatment in a rabbit in vivo cartilage trauma model. Animals were randomly divided into group A (right joint: trauma (T); left joint: T+BMP7) and group B (right joint: T+NAC; left joint: T+BMP7+NAC). Condyles were impacted with the use of a spring-loaded impact device to ensure defined, single trauma administration. After 12 weeks, histopathological analysis was performed and the presence of matrix metalloproteinase 13 (MMP-13) and COL2 was assessed. Trauma-induced hypocellularity, MMP-13 expression, and cell cluster formation were reduced in NAC-treated animals. In contrast, BMP7 further increased cluster formation. Moreover, synovial concentrations of COL2 carboxy propeptide (CPII) and proteoglycan staining intensities were enhanced in NAC- and NAC+BMP7-treated joints. For the first time, the efficacy of NAC regarding early harm reduction after blunt cartilage trauma was demonstrated in vivo. However, parallel administration of BMP7 was not significantly superior compared to NAC alone.
Effect of the 5-HT2C Receptor Agonist WAY-163909 on Serotonin and Dopamine Metabolism across the Rat Brain: A Quantitative and Qualitative Neurochemical Study
Authors: Whitestone Sara , De Deurwaerdère Philippe , Baassiri Lynn , Manem Julien , Anouar Youssef , Di Giovanni Giuseppe , Bharatiya Rahul , Chagraoui Abdeslam
Published: June 2019

The effects triggered by serotonin2C (5-hydroxytryptamin2C, 5-HT2C) receptor agonists in the brain are often subtle, and methodologies highlighting their widespread actions to account for their multiple modulatory influences on behaviors are still lacking. We report an extended analysis of a neurochemical database on monoamines obtained after the intraperitoneal administration of the preferential 5-HT2C receptor agonist WAY-163909 (0.3 and 3 mg/kg) in 29 distinct rat brain regions. We focused on the metabolite of 5-HT, 5-hydroxyindoleacetic acid (5-HIAA), the metabolites of dopamine (DA), 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA), and the index of the turnovers 5-HIAA/5-HT and DOPAC/DA. WAY-163909 increased and decreased 5-HIAA tissue levels in the amygdala and dorsolateral orbitofrontal cortex, respectively, and decreased the 5-HT turnover in the infralimbic cortex. It enhanced HVA levels in the medial orbitofrontal cortex and DOPAC levels in the amygdala. WAY-163909 increased and decreased DA turnover in the medial orbitofrontal cortex and the anterior insular cortex, respectively. The correlative analysis of the turnovers between pairs of brain regions revealed low levels of correlations across the brain but presented a distinct pattern of correlations after WAY-163909 was compared to saline-treated rats. WAY-163909, notably at 0.3 mg/kg, favored cortico-cortical and cortico-subcortical correlations of both turnovers separately, and frontal DOPAC/DA ratio with cortical and subcortical 5-HIAA/5-HT ratios at 3 mg/kg. In conclusion, the qualitative, but not the quantitative analysis shows that WAY-163909 alters the pattern of correlations across the brain, which could account for its multiple behavioral influences.
First Principles Study of the Vibrational and Thermal Properties of Sn-Based Type II Clathrates, CsxSn136 (0 ≤ x ≤ 24) and Rb24Ga24Sn112
Authors: Zahid Hadeel , Xue Dong , Myles Charles
Published: June 2019

After performing first-principles calculations of structural and vibrational properties of the semiconducting clathrates Rb24Ga24Sn112 along with binary CsxSn136 (0 ≤ x ≤ 24), we obtained equilibrium geometries and harmonic phonon modes. For the filled clathrate Rb24Ga24Sn112, the phonon dispersion relation predicts an upshift of the low-lying rattling modes (~25 cm−1) for the Rb (“rattler”) compared to Cs vibration in CsxSn136. It is also found that the large isotropic atomic displacement parameter (Uiso) exists when Rb occupies the “over-sized” cage (28 atom cage) rather than the 20 atom counterpart. These guest modes are expected to contribute significantly to minimizing the lattice’s thermal conductivity (κL). Our calculation of the vibrational contribution to the specific heat and our evaluation on κL are quantitatively presented and discussed. Specifically, the heat capacity diagram regarding CV/T3 vs. T exhibits the Einstein-peak-like hump that is mainly attributable to the guest oscillator in a 28 atom cage, with a characteristic temperature 36.82 K for Rb24Ga24Sn112. Our calculated rattling modes are around 25 cm−1 for the Rb trapped in a 28 atom cage, and 65.4 cm−1 for the Rb encapsulated in a 20 atom cage. These results are utilized to predict the lattice’s thermal conductivity (approximately 0.62 W/m/K) in Rb24Ga24Sn112 within the kinetic theory approximation.
Andean Flora as a Source of New Repellents against Insect Pests: Behavioral, Morphological and Electrophysiological Studies on Sitophilus zeamais (Coleoptera: Curculionidae)
Authors: Romani Roberto , Bedini Stefano , Salerno Gianandrea , Ascrizzi Roberta , Flamini Guido , Echeverria Maria Cristina , Farina Priscilla , Conti Barbara
Published: June 2019

Sitophilus zeamais (Motschulsky) is considered as one of the most destructive foodstuff pests. Due to their efficiency, low toxicity for mammalians and low environmental impact, plant-derived essential oils (EOs) are promising tools for pest control. In particular, the OEs extracted from Lamiaceae are considered among the most bioactive in terms of repellent and/or insecticidal effect. Here, we investigated the repellence of the EOs extracted from two aromatic plant species typical of the flora of the Ecuadorian Andes, Clinopodium tomentosum and C. nubigeum, against adults of S. zeamais. The behavioral assays carried out at concentrations ranging from 0.7 to 23.9 μL L−1 air in a two-way static olfactometer showed a significant repellent effect starting from the concentration of 8.4 mL L−1 air both for the EO of C. nubigenum and C. tomentosum. We also carried out a complete structural analysis of the antenna of S. zeamais using scanning (SEM) and transmission electron microscopy (TEM), in order to characterize the olfactory sensilla equipment. In this species, there is no sexual dimorphism also as regards to the antennal morphology and the sensilla type and distribution. We identified six type of sensilla, among which at least three types (Sensillum Trichoideum 1, Sensillum Trichoideum 2 and Grooved Peg Sensillum) can be considered as olfactory. Electroantennography (EAG) recordings carried out on S. zeamais revealed a positive dose-response to both EOs, without differences between the two sexes.
Serologic and Histologic Predictors of Long-Term Renal Outcome in Biopsy-Confirmed IgA Nephropathy (Haas Classification): An Observational Study
Authors: Tsai Shang-Feng , Wu Ming-Ju , Wen Mei-Chin , Chen Cheng-Hsu
Published: June 2019

Background and objective: The Haas classification of IgA nephropathy should be validated for Asian populations. More detailed and newer predictions regarding renal outcome of IgA nephropathy remains mandatory. Materials: We conducted a retrospective cohort study between January 2003 and December 2013. Clinical, Pathological, and laboratory data were all collected via available medical records. A Mann–Whitney U test was used for continuous variables and the Chi-square test was implemented for categorical variables. A Kaplan–Meier curve was put in place in order to determine patient survival and renal survival. The Youden index and Cox proportional hazard regression were used to investigate the possible factors for renal survival and predictive power. Results: All 272 renal biopsy-confirmed IgAN patients were enrolled for further studies. The univariate analysis showed that risk factors for poor renal outcome included stage 4–5 of Haas classification (HR = 3.67, p < 0.001), a poor baseline renal function (HR = 1.02 and p < 0.001 for higher BUN; HR = 1.14 and p < 0.001 for higher serum creatinine; HR = 0.95, p < 0.001 for higher eGFR), IgG ≤ 907 (HR = 2.29, p = 0.003), C3 ≤ 79.7 (HR = 2.76, p = 0.002), a higher C4 (HR = 1.02, p = 0.026), neutrophil-to-lymphocyte ratio > 2.75 (HR = 2.92, p < 0.001), and a platelet-to-lymphocyte ratio ≥ 16.06 (HR = 2.02, p = 0.012). A routine-checked markers, such as neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio, in order to predict the renal outcome, is recommended. Conclusions: This is the first study to demonstrate that Haas classification is also useful for establishing predictive values in Asian groups. A lower serum IgG (≤907 mg/dL) and serum C3 (≤79.7 mg/dL) were both risk factors for poor renal outcome. Additionally, this is the first study to reveal that serum C4 levels, an NLR > 2.75 and a PLR > 16.06, S could suggest poor renal outcome.
MicroRNA Profile of HCV Spontaneous Clarified Individuals, Denotes Previous HCV Infection
Authors: Brochado-Kith Óscar , Gómez Sanz Alicia , Real Luis Miguel , Crespo García Javier , Ryan Murúa Pablo , Macías Juan , Cabezas González Joaquín , Troya Jesús , Pineda Juan Antonio , Arias Loste María Teresa , Díez Viñas Victorino , Jiménez-Sousa María Ángeles , Medrano de Dios Luz María , Cuesta De la Plaza Isabel , Monzón Fernández Sara , Resino García Salvador , Fernández-Rodríguez Amanda
Published: June 2019

Factors involved in the spontaneous cleareance of a hepatitis C (HCV) infection are related to both HCV and the interaction with the host immune system, but little is known about the consequences after a spontaneous resolution. The main HCV extrahepatic reservoir is the peripheral blood mononuclear cells (PBMCs), and their transcriptional profile provides us information of innate and adaptive immune responses against an HCV infection. MicroRNAs regulate the innate and adaptive immune responses, and they are actively involved in the HCV cycle. High Throughput sequencing was used to analyze the miRNA profiles from PBMCs of HCV chronic naïve patients (CHC), individuals that spontaneously clarified HCV (SC), and healthy controls (HC). We did not find any differentially expressed miRNAs between SC and CHC. However, both groups showed similar expression differences (21 miRNAs) with respect to HC. This miRNA signature correctly classifies HCV-exposed (CHC and SC) vs. HC, with the has-miR-21-3p showing the best performance. The potentially targeted molecular pathways by these 21 miRNAs mainly belong to fatty acids pathways, although hippo signaling, extracellular matrix (ECM) interaction, proteoglycans-related, and steroid biosynthesis pathways were also altered. These miRNAs target host genes involved in an HCV infection. Thus, an HCV infection promotes molecular alterations in PBMCs that can be detected after an HCV spontaneous resolution, and the 21-miRNA signature is able to identify HCV-exposed patients (either CHC or SC).
Financial Structure, Misery Index, and Economic Growth: Time Series Empirics from Pakistan
Authors: Wang Nianyong , Haroon Shah Muhammad , Ali Kishwar , Abbas Shah , Ullah Sami
Published: June 2019

This study empirically analyzes the impact of the financial structure and misery index on economic growth in Pakistan. We adopted Autoregressive-Distributed Lag (ARDL) for a co-integration approach to the data analysis and used time series data from 1989 to 2017. We used GDP as the dependent variable; the Financial Development index (FDI) and misery index as the explanatory variables; and remittances, real interest, and trade openness as the control variables. The empirical results indicate the existence of a long-term relationship among the included variables in the model and the FD index, misery index, interest rate, trade openness, and remittances as the main affecting variables of GDP in the long run. The government needs appropriate reform in the financial sector and external sector in order to achieve a desirable level of economic growth in Pakistan. The misery index is constructed based on unemployment and inflation, which has a negative implication on the economic growth, and the government needs policies to reduce unemployment and inflation.
Performance of Hybrid Powder-Suspension Axial Plasma Sprayed Al2O3—YSZ Coatings in Bovine Serum Solution
Authors: Gopal Vasanth , Goel Sneha , Manivasagam Geetha , Joshi Shrikant
Published: June 2019

Ceramic coatings on metallic implants are a promising alternative to conventional implants due to their ability to offer superior wear resistance. The present work investigates the sliding wear behavior under bovine serum solution and indentation crack growth resistance of four coatings, namely (1) conventional powder-derived alumina coating (Ap), (2) suspension-derived alumina coating (As), (3) composite Al2O3—20wt % Yittria stabilized Zirconia (YSZ) coating (AsYs) deposited using a mixed suspension, and (4) powder Al2O3—suspension YSZ hybrid composite coating ApYs developed by axial feeding plasma spraying, respectively. The indentation crack growth resistance of the hybrid coating was superior due to the inclusion of distributed fine YSZ particles along with coarser alumina splats. Enhanced wear resistance was observed for the powder derived Ap and the hybrid ApYs coatings, whereas the suspension sprayed As and AsYs coatings significantly deteriorated due to extensive pitting.
Study on Non-Commutativity Measure of Quantum Discord
Authors: Liang Jin , Zhang Chengwei
Published: June 2019

In this paper, we are concerned with the non-commutativity measure of quantum discord. We first present an explicit expression of the non-commutativity measure of quantum discord in the two-qubit case. Then we compare the geometric quantum discords for two dynamic models with their non-commutativity measure of quantum discords. Furthermore, we show that the results conducted by the non-commutativity measure of quantum discord are different from those conducted by both or one of the Hilbert-Schmidt distance discord and trace distance discord. These intrinsic differences indicate that the non-commutativity measure of quantum discord is incompatible with at least one of the well-known geometric quantum discords in the quantitative and qualitative representation of quantum correlations.
Solutions of Direct and Inverse Even-Order Sturm-Liouville Problems Using Magnus Expansion
Authors: Perera Upeksha , Böckmann Christine
Published: June 2019

In this paper Lie group method in combination with Magnus expansion is utilized to develop a universal method applicable to solving a Sturm–Liouville problem (SLP) of any order with arbitrary boundary conditions. It is shown that the method has ability to solve direct regular (and some singular) SLPs of even orders (tested for up to eight), with a mix of (including non-separable and finite singular endpoints) boundary conditions, accurately and efficiently. The present technique is successfully applied to overcome the difficulties in finding suitable sets of eigenvalues so that the inverse SLP problem can be effectively solved. The inverse SLP algorithm proposed by Barcilon (1974) is utilized in combination with the Magnus method so that a direct SLP of any (even) order and an inverse SLP of order two can be solved effectively.
A New Algorithm for Fractional Riccati Type Differential Equations by Using Haar Wavelet
Authors: Khashan M. Motawi , Amin Rohul , Syam Muhammed I.
Published: June 2019

In this paper, a new collocation method based on Haar wavelet is developed for numerical solution of Riccati type differential equations with non-integer order. The fractional derivatives are considered in the Caputo sense. The method is applied to one test problem. The maximum absolute estimated error functions are calculated, and the performance of the process is demonstrated by calculating the maximum absolute estimated error functions for a distinct number of nodal points. The results show that the method is applicable and efficient.
Resistance Change Mechanism of Electronic Component Mounting through Contact Pressure Using Elastic Adhesive
Authors: Sato Takashi , Koshi Tomoya , Iwase Eiji
Published: June 2019

For mounting electronic components through contact pressure using elastic adhesives, a high contact resistance is an inevitable issue in achieving solderless wiring in a low-temperature and low-cost process. To decrease the contact resistance, we investigated the resistance change mechanism by measuring the contact resistance with various contact pressures and copper layer thicknesses. The contact resistivity decreased to 4.2 × 10−8 Ω·m2 as the contact pressure increased to 800 kPa and the copper layer thickness decreased to 5 µm. In addition, we measured the change in the total resistance with various copper layer thicknesses, including the contact and wiring resistance, and obtained the minimum combined resistance of 123 mΩ with a copper-layer thickness of 30 µm using our mounting method. In this measurement, a low contact resistance was obtained with a 5-µm-thick copper layer and a contact pressure of 200 kPa or more; however, there is a trade-off with respect to the copper layer thickness in obtaining the minimum combined resistance because of the increasing wiring resistance. Subsequently, based on these measurements, we developed a sandwich structure to decrease the contact resistance, and a contact resistivity of 8.0 × 10−8 Ω·m2 was obtained with the proposed structure.
Bovine Milk Oligosaccharides with Sialyllactose Improves Cognition in Preterm Pigs
Authors: Obelitz-Ryom Karina , Bering Stine Brandt , Overgaard Silja Hvid , Eskildsen Simon Fristed , Ringgaard Steffen , Olesen Jonas Lynge , Skovgaard Kerstin , Pankratova Stanislava , Wang Bing , Brunse Anders , Heckmann Anne Birgitte , Rydal Martin Peter , Sangild Per Torp , Thymann Thomas
Published: June 2019

Optimal nutrition is important after preterm birth to facilitate normal brain development. Human milk is rich in sialic acid and preterm infants may benefit from supplementing formula with sialyllactose to support neurodevelopment. Using pigs as models, we hypothesized that sialyllactose supplementation improves brain development after preterm birth. Pigs (of either sex) were delivered by cesarean section at 90% gestation and fed a milk diet supplemented with either an oligosaccharide-enriched whey with sialyllactose (n = 20) or lactose (n = 20) for 19 days. Cognitive performance was tested in a spatial T-maze. Brains were collected for ex vivo magnetic resonance imaging (MRI), gene expression, and sialic acid measurements. For reference, term piglets (n = 14) were artificially reared under identical conditions and compared with vaginally born piglets naturally reared by the sow (n = 12). A higher proportion of sialyllactose supplemented preterm pigs reached the T-maze learning criteria relative to control preterm pigs (p < 0.05), and approximated the cognition level of term reference pigs (p < 0.01). Furthermore, supplemented pigs had upregulated genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in hippocampus. Sialyllactose supplementation did not lead to higher levels of sialic acid in the hippocampus or change MRI endpoints. Contrary, these parameters were strongly influenced by postconceptional age and postnatal rearing conditions. In conclusion, oligosaccharide-enriched whey with sialyllactose improved spatial cognition, with effects on hippocampal genes related to sialic acid metabolism, myelination, and ganglioside biosynthesis in preterm pigs. Dietary sialic acid enrichment may improve brain development in infants.
Effect of Postoperative Oral Intake on Prognosis for Esophageal Cancer
Authors: Okada Genya , Momoki Chika , Habu Daiki , Kambara Chisako , Fujii Tamotsu , Matsuda Yasunori , Lee Shigeru , Osugi Harushi
Published: June 2019

Background: Patients undergoing surgery for esophageal cancer are at risk of prolonged hospital stay for postoperative malnutrition. Postoperative early oral feeing is a part of the “enhanced recovery after surgery protocol” for coping with this risk. However, the usefulness of early oral intake during perioperatively is questionable. Methods: In total, 117 patients treated surgically for esophageal cancer were analyzed in the study. We assessed the oral energy sufficiency rate per nutritional requirement (oral-E/NR) at the fourth week postoperatively and classified the patients into two groups: Poor oral intake group (POI group; <25% oral-E/NR) and the control group (≥25% oral-E/NR). We analyzed the relationship among postoperative oral intake and prognoses. Results: The POI group had worse postoperative nutritional status and a lower survival rate than the control group. In a multivariate analysis, <25% oral-E/NR was one of the independent factors contributing to negative outcomes postoperatively (adjusted hazard ratio: 2.70, 95% confidence interval: 1.30–5.61). Conclusions: In patients undergoing surgery for esophageal cancer, poor postoperative oral intake negatively affected not only on their postoperative nutritional status but also their overall prognosis. It is necessary to improve the adequacy of oral intake postoperatively for patients with esophageal cancer.
Procedure to Estimate Added and Free Sugars in Food Items from the Swedish Food Composition Database Used in the National Dietary Survey Riksmaten Adolescents 2016–17
Authors: Wanselius Julia , Axelsson Cecilia , Moraeus Lotta , Berg Christina , Mattisson Irene , Larsson Christel
Published: June 2019

A high intake of added and free sugars is associated with poor diet quality, caries, and potentially has a role in non-communicable diseases. As a result, dietary guidelines advice limitation. However, there is no standardized method for estimation of added and free sugars in food items and consequently intake is difficult to measure. This study aimed to refine a procedure for sugars estimation and apply it to a Swedish dietary survey on adolescents (Riksmaten Adolescents 2016–17). A national sample of 3099 adolescents in school year 5, 8 and 11 participated (55% girls). Individual dietary intake data from two non-consecutive days was collected retrospectively and used for analysis. A ten-step systematic procedure for estimation of sugars in a Swedish context has been developed by combining two earlier methods, one for estimation of added sugars and one for free sugars. Sugars estimates were made for all food items comprising the survey database. Mainly objective decisions were necessary to make the estimates (92% and 93% for the sugars respectively); meaning that the procedure was largely transparent. In relation to Nordic Nutrition Recommendations, 45% of the participants had an intake that adhered to the guidelines. However, the majority of intakes was close to the recommendation. Further research on how specific food sources contribute to added and free sugars is necessary to facilitate further guidance on sugars and how to reach recommended target levels in Sweden.
Robustness of Food Processing Classification Systems
Authors: Bleiweiss-Sande Rachel , Chui Kenneth , Evans E. Whitney , Goldberg Jeanne , Amin Sarah , Sacheck Jennifer
Published: June 2019

Discrepancies exist among food processing classification systems and in the relationship between processed food intake and dietary quality of children. This study compared inter-rater reliability, food processing category, and the relationship between processing category and nutrient concentration among three systems (Nova, International Food Information Council (IFIC), and University of North Carolina at Chapel Hill (UNC)). Processing categories for the top 100 most commonly consumed foods children consume (NHANES 2013–2014) were independently coded and compared using Spearman’s rank correlation coefficient. Relative ability of nutrient concentration to predict processing category was investigated using linear discriminant analysis and multinomial logistic regression and compared between systems using Cohen’s kappa coefficient. UNC had the highest inter-rater reliability (ρ = 0.97), followed by IFIC (ρ = 0.78) and Nova (ρ = 0.76). UNC and Nova had the highest agreement (80%). Lower potassium was predictive of IFIC’s classification of foods as moderately compared to minimally processed (p = 0.01); lower vitamin D was predictive of UNC’s classification of foods as highly compared to minimally processed (p = 0.04). Sodium and added sugars were predictive of all systems’ classification of highly compared to minimally processed foods (p < 0.05). Current classification systems may not sufficiently identify foods with high nutrient quality commonly consumed by children in the U.S.
Novel Ideas in Nonleptonic Decays of Double Heavy Baryons
Authors: Gutsche Thomas , Ivanov Mikhail , Körner Jürgen , Lyubovitskij Valery
Published: June 2019

The recent discovery of double charm baryon states by the LHCb Collaborarion and their high precision mass determination calls for a comprehensive analysis of the nonleptonic decays of double and single heavy baryons. Nonleptonic baryon decays play an important role in particle phenomenology since they allow for studying the interplay of long and short distance dynamics of the Standard Model (SM). Furthermore, they allow one to search for New Physics effects beyond the SM. We review recent progress in experimental and theoretical studies of the nonleptonic decays of heavy baryons with a focus on double charm baryon states and their decays. In particular, we discuss new ideas proposed by the present authors to calculate the W-exchange matrix elements of the nonleptonic decays of double heavy baryons. An important ingredient in our approach is the compositeness condition of Salam and Weinberg, and an effective implementation of infrared confinement both of which allow one to describe the nonperturbative structure of baryons composed of light and heavy quarks. Furthermore, we discuss an ab initio calculational method for the treatment of the so-called W-exchange diagrams generated by W ± boson exchange between quarks. We found that the W ± -exchange contributions are not suppressed in comparison with the tree-level (factorizing) diagrams and must be taken into account in the evaluation of matrix elements. Moreover, there are decay processes such as the doubly Cabibbo-suppressed decay Ξ c + → p ϕ recently observed by the LHCb Collaboration, which is contributed to only by one single W-exchange diagram.
Synchronized Optical and Acoustic Droplet Vaporization for Effective Sonoporation
Authors: Liu Wei-Wen , Huang Sy-Han , Li Pai-Chi
Published: June 2019

Inertial cavitation-based sonoporation has been utilized to enhance treatment delivery efficacy. In our previous study, we demonstrated that tumor therapeutic efficacy can be enhanced through vaporization-assisted sonoporation with gold nanodroplets (AuNDs). Specifically, the AuNDs were vaporized both acoustically (i.e., acoustic droplet vaporization, ADV) and optically (i.e., optical droplet vaporization, ODV). A continuous wave (CW) laser was used for ODV in combination with an ultrasound pulse for ADV. Although effective for vaporization, the use of a CW laser is not energy efficient and may create unwanted heating and concomitant tissue damage. In this study, we propose the use of a pulsed wave (PW) laser to replace the CW laser. In addition, the PW laser was applied at the rarefaction phase of the ultrasound pulse so that the synergistic effects of ADV and ODV can be expected. Therefore, a significantly lower laser average power can be expected to achieve the vaporization threshold. Compared to the CW laser power at 2 W/cm2 from the previous approach, the PW laser power was reduced to only 0.2404 W/cm2. Furthermore, we also demonstrate in vitro that the sonoporation rate was increased when the PW laser was applied at the rarefaction phase. Specifically, the vaporization signal, the inertial cavitation signal, and the sonoporation rate all displayed a 1-µs period, which corresponded to the period of the 1-MHz acoustic wave used for ADV, as a function of the relative laser delay. The increased sonoporation rate indicates that this technique has the potential to enhance sonoporation-directed drug delivery and tumor therapy with a lower laser power while keeping the cell death rate at the minimum. Photoacoustic imaging can also be performed at the same time since a PW laser is used for the ODV.
Prescribing Patterns of Antihypertensive Medications in US Ambulatory Care Settings
Authors: Sahakian Yelena , Bylykbashi Brisilda , Rahman Ateequr
Published: June 2019

Over 70 million Americans are diagnosed with hypertension. Adherence to current AHA/ACC 2017 hypertension guidelines and appropriate antihypertensive therapy is important for optimal treatment outcomes. This study investigates prescribing patterns for ambulatory care patients with hypertension and adherence to these guidelines. Data from the 2015 National Ambulatory Medical Care Survey (NAMCS) were used in the study. Patients with primary diagnoses of essential hypertension were extracted from the data using ICD-9 code “401”. A total of 595 patients were identified. Correlation among demographic variables, source of payment and prescriber specialty were examined. Chi-square and descriptive analysis were performed. 51.4% of the prescriptions were non-first-line medications. Primary care physicians and cardiologists adhered to the guidelines more, when compared to the other specialties. There was a significant difference between various geographic regions, as it relates to guidelines adherence. This study concluded that prescribers do not always adhere to the AHA/ACC 2017 hypertension guidelines. It is recommended to adhere to the guidelines if there are no contraindications. The study’s findings were limited to the ambulatory patients visiting providers in 2015 and by the operational definitions of the study.
Effect of Water Stress during Grain Filling on Yield, Quality and Physiological Traits of Illpa and Rainbow Quinoa (Chenopodium quinoa Willd.) Cultivars
Authors: Gámez Angie L. , Soba David , Zamarreño Ángel M. , García-Mina José M. , Aranjuelo Iker , Morales Fermín
Published: June 2019

The total area under quinoa (Chenopodium quinoa Willd.) cultivation and the consumption of its grain have increased in recent years because of its nutritional properties and ability to grow under adverse conditions, such as drought. Climate change scenarios predict extended periods of drought and this has emphasized the need for new crops that are tolerant to these conditions. The main goal of this work was to evaluate crop yield and quality parameters and to characterize the physiology of two varieties of quinoa grown under water deficit in greenhouse conditions. Two varieties of quinoa from the Chilean coast (Rainbow) and altiplano (Illpa) were used, grown under full irrigation or two different levels of water deficit applied during the grain filling period. There were no marked differences in yield and quality parameters between treatments, but the root biomass was higher in plants grown under severe water deficit conditions compared to control. Photosynthesis, transpiration and stomatal conductance decreased with increased water stress in both cultivars, but the coastal variety showed higher water use efficiency and less discrimination of 13C under water deficit. This response was associated with greater root development and a better stomatal opening adjustment, especially in the case of Rainbow. The capacity of Rainbow to increase its osmoregulant content (compounds such as proline, glutamine, glutamate, K and Na) could enable a potential osmotic adjustment in this variety. Moreover, the lower stomatal opening and transpiration rates were also associated with higher leaf ABA concentration values detected in Rainbow. We found negative logarithmic relationships between stomatal conductance and leaf ABA concentration in both varieties, with significant R2 values of 0.50 and 0.22 in Rainbow and Illpa, respectively. These moderate-to-medium values suggest that, in addition to ABA signaling, other causes for stomatal closure in quinoa under drought such as hydraulic regulation may play a role. In conclusion, this work showed that two quinoa cultivars use different strategies in the face of water deficit stress, and these prevent decreases in grain yield and quality under drought conditions.
Influence of Branching on the Configurational and Dynamical Properties of Entangled Polymer Melts
Authors: Chremos Alexandros , Douglas Jack F.
Published: June 2019

We probe the influence of branching on the configurational, packing, and density correlation function properties of polymer melts of linear and star polymers, with emphasis on molecular masses larger than the entanglement molecular mass of linear chains. In particular, we calculate the conformational properties of these polymers, such as the hydrodynamic radius R h , packing length p, pair correlation function g ( r ) , and polymer center of mass self-diffusion coefficient, D, with the use of coarse-grained molecular dynamics simulations. Our simulation results reproduce the phenomenology of simulated linear and branched polymers, and we attempt to understand our observations based on a combination of hydrodynamic and thermodynamic modeling. We introduce a model of “entanglement” phenomenon in high molecular mass polymers that assumes polymers can viewed in a coarse-grained sense as “soft” particles and, correspondingly, we model the emergence of heterogeneous dynamics in polymeric glass-forming liquids to occur in a fashion similar to glass-forming liquids in which the molecules have soft repulsive interactions. Based on this novel perspective of polymer melt dynamics, we propose a functional form for D that can describe our simulation results for both star and linear polymers, covering both the unentangled to entangled polymer melt regimes.
On the Automated Mapping of Snow Cover on Glaciers and Calculation of Snow Line Altitudes from Multi-Temporal Landsat Data
Authors: Rastner Philipp , Prinz Rainer , Notarnicola Claudia , Nicholson Lindsey , Sailer Rudolf , Schwaizer Gabriele , Paul Frank
Published: June 2019

Mapping snow cover (SC) on glaciers at the end of the ablation period provides a possibility to rapidly obtain a proxy for their equilibrium line altitude (ELA) which in turn is a metric for the mass balance. Satellite determination of glacier snow cover, derived over large regions, can reveal its spatial variability and temporal trends. Accordingly, snow mapping on glaciers has been widely applied using several satellite sensors. However, as glacier ice originates from compressed snow, both have very similar spectral properties and standard methods to map snow struggle to distinguish snow on glaciers. Hence, most studies applied manual delineation of snow extent on glaciers. Here we present an automated tool, named ‘ASMAG’ (automated snow mapping on glaciers), to map SC on glaciers and derive the related snow line altitude (SLA) for individual glaciers using multi-temporal Landsat satellite imagery and a digital elevation model (DEM). The method has been developed using the example of the Ötztal Alps, where an evaluation of the method is possible using field-based observations of the annual equilibrium line altitude (ELA) and the accumulation area ratio (AAR) measured for three glaciers for more than 30 years. The tool automatically selects a threshold to map snow on glaciers and robustly calculates the SLA based on the frequency distribution of elevation bins with more than 50% SC. The accuracy of the SC mapping was about 90% and the SLA was determined successfully in 80% of all cases with a mean uncertainty of ±19 m. When cloud-free scenes close to the date of the highest snowline are available, a good to very good agreement of SC ratios (SCR)/SLA with field data of AAR/ELA are obtained, otherwise values are systematically higher/lower as useful images were often acquired too early in the summer season. However, glacier specific differences are still well captured. Snow mapping on glaciers is impeded by clouds and their shadows or when fresh snow is covering the glaciers, so that more frequent image acquisitions (as now provided by Sentinel-2) would improve results.
Classification of Tropical Forest Tree Species Using Meter-Scale Image Data
Authors: Cross Matthew , Scambos Ted , Pacifici Fabio , Vargas-Ramirez Orlando , Moreno-Sanchez Rafael , Marshall Wesley
Published: June 2019

Accurate classification of tropical tree species is critical for understanding forest habitat, biodiversity, forest composition, biomass, and the role of trees in climate variability through carbon uptake. The aim of this study is to establish an accurate classification procedure for tropical tree species, specifically testing the feasibility of WorldView-3 (WV-3) multispectral imagery for this task. The specific study site is a defined arboretum within a well-known tropical forest research location in Costa Rica (La Selva Biological Station). An object-based classification is the basis for the analysis to classify six selected tree species. A combination of pre-processed WV-3 bands were inputs to the classification, and an edge segmentation process defined multi-pixel-scale tree canopies. WorldView-3 bands in the Green, Red, Red Edge, and Near-Infrared 2, particularly when incorporated in two specialized vegetation indices, provide high discrimination among the selected species. Classification results yield an accuracy of 85.37%, with minimal errors of commission (7.89%) and omission (14.63%). Shadowing in the satellite imagery had a significant effect on segmentation accuracy (identifying single-species canopy tops) and on classification. The methodology presented provides a path to better characterization of tropical forest species distribution and overall composition for improving biomass studies in a tropical environment.
Electrooculograms for Human–Computer Interaction: A Review
Authors: Chang Won-Du
Published: June 2019

Eye movements generate electric signals, which a user can employ to control his/her environment and communicate with others. This paper presents a review of previous studies on such electric signals, that is, electrooculograms (EOGs), from the perspective of human–computer interaction (HCI). EOGs represent one of the easiest means to estimate eye movements by using a low-cost device, and have been often considered and utilized for HCI applications, such as to facilitate typing on a virtual keyboard, moving a mouse, or controlling a wheelchair. The objective of this study is to summarize the experimental procedures of previous studies and provide a guide for researchers interested in this field. In this work the basic characteristics of EOGs, associated measurements, and signal processing and pattern recognition algorithms are briefly reviewed, and various applications reported in the existing literature are listed. It is expected that EOGs will be a useful source of communication in virtual reality environments, and can act as a valuable communication tools for people with amyotrophic lateral sclerosis.