bluuebunny/crossref_metadata_2025 huggingface dataset:
NfL reliability across laboratories, stage-dependent diagnostic performance and matrix comparability in genetic FTD: a large GENFI study
Authors: Linnemann Christoph , Wilke Carlo , Mengel David , Zetterberg Henrik , Heller Carolin , Kuhle Jens , Bouzigues Arabella , Russell Lucy L , Foster Phoebe H , Ferry-Bolder Eve , Van Swieten John Cornelis , Jiskoot Lize C , Seelaar Harro , Moreno Fermin , Borroni Barbara , Sánchez-Valle Raquel , Galimberti Daniela , Laforce Robert , Graff Caroline , Masellis Mario , Tartaglia Maria Carmela , Rowe James Benedict , Finger Elizabeth , Vandenberghe Rik , de Mendonca Alexandre , Butler Chris R , Gerhard Alexander , Ducharme Simon , Ber Isabelle L E , Tiraboschi Pietro , Santana Isabel , Pasquier Florence , Levin Johannes , Otto Markus , Sorbi Sandro , Rohrer Jonathan Daniel , Synofzik Matthis
Published: January 2024

Background

Blood neurofilament light chain (NfL) is increasingly considered as a key trial biomarker in genetic frontotemporal dementia (gFTD). We aimed to facilitate the use of NfL in gFTD multicentre trials by testing its (1) reliability across labs; (2) reliability to stratify gFTD disease stages; (3) comparability between blood matrices and (4) stability across recruiting sites.

Methods

Comparative analysis of blood NfL levels in a large gFTD cohort (GENFI) for (1)–(4), with n=344 samples (n=148 presymptomatic, n=11 converter, n=46 symptomatic subjects, with mutations inC9orf72,GRNorMAPT; and n=139 within-family controls), each measured in three different international labs by Simoa HD-1 analyzer.

Results

NfL revealed an excellent consistency (intraclass correlation coefficient (ICC) 0.964) and high reliability across the three labs (maximal bias (pg/mL) in Bland-Altman analysis: 1.12±1.20). High concordance of NfL across laboratories was moreover reflected by high areas under the curve for discriminating conversion stage against the (non-converting) presymptomatic stage across all three labs. Serum and plasma NfL were largely comparable (ICC 0.967). The robustness of NfL across 13 recruiting sites was demonstrated by a linear mixed effect model.

Conclusions

Our results underline the suitability of blood NfL in gFTD multicentre trials, including cross-lab reliable stratification of the highly trial-relevant conversion stage, matrix comparability and cross-site robustness.
Myotonic dystrophy type 1: palliative care guidelines
Authors: Willis Derek , Willis Tracey , Bassie Claire , Eglon Gail , Ashley Emma-Jayne , Turner Chris
Published: January 2024

Palliative care for adults with neuromuscular conditions is an emerging field. Previous guidelines regarding myotonic dystrophy and palliative care have only mentioned end-of-life care and little else. The following guidelines have been written using national experts as a description of best practice as part of the Dystrophia Myotonica National Care Guidelines Consortium.
Note on NLSM tree amplitudes and soft theorems
Authors: Zhou Kang , Wei Fang-Stars
Published: January 2024

This note provides a new point of view for bootstrapping the tree amplitudes of the nonlinear sigma model (NLSM). We use the universality of single soft behavior, together with the double copy structure, to completely determine the tree amplitudes of the NLSM. We first observe Adler’s zero for four-point NLSM amplitudes, by considering kinematics. Then we assume the universality of Adler’s zero and use this requirement to construct general tree amplitudes of the NLSM in the expanded formula, i.e., the formula of expanding NLSM amplitudes to bi-adjoint scalar amplitudes, which allows us to give explicit expressions of amplitudes with arbitrary numbers of external legs. The construction does not require the assumption of quartic diagrams. We also derive double soft factors for NLSM tree amplitudes based on the resulting expanded formula, and the results are consistent with those in the literature.
Relic gravitons and pulsar timing arrays: a theoretical viewpoint
Authors: Giovannini Massimo
Published: January 2024

During the last 3 years the pulsar timing arrays reported a series of repeated evidences of gravitational radiation (with stochastically distributed Fourier amplitudes) at a benchmark frequency of the order of 30 nHz and characterized by spectral energy densities (in critical units) ranging between $$10^{-8}$$

10

-
8

and $$10^{-9}$$

10

-
9

. While it is still unclear whether or not these effects are just a consequence of the pristine variation of the space-time curvature, the nature of the underlying physical processes would suggest that the spectral energy density of the relic gravitons in the nHz domain may only depend on the evolution of the comoving horizon at late, intermediate and early times. Along this systematic perspective we first consider the most conventional option, namely a post-inflationary modification of the expansion rate. Given the present constraints on the relic graviton backgrounds, we then show that such a late-time effect is unable to produce the desired hump in the nHz region. We then analyze a modified exit of the relevant wavelengths as it may happen when the gravitons inherit an effective refractive index from the interactions with the geometry. A relatively short inflationary phase leads, in this case, to an excess in the nHz region even if the observational data coming from competing experiments do not pin down exactly the same regions in the parameter space. We finally examine an early stage of increasing curvature and argue that it is not compatible with the observed spectral energy density unless the wavelengths crossing the comoving horizon at early times reenter in a decelerated stage not dominated by radiation.
Spectrum of FO Logic with Quantifier Depth 4 is Finite
Authors: Yarovikov Yury , Zhukovskii Maksim
Published: January 2024

The
k
-spectrum is the set of all
α
> 0 such that
G(n,n
−α
) does not obey the 0-1 law for FO sentences with quantifier depth at most
k
. In this article, we prove that the minimum
k
such that the
k
-spectrum is infinite equals 5.
PAM-FOG Net: A Lightweight Weed Detection Model Deployed on Smart Weeding Robots
Authors: Bao Jiahua , Cheng Siyao , Liu Jie
Published: January 2024

Visual target detection based on deep learning with high computing power devices has been successful, but the performance in intelligent agriculture with edge devices has not been prominent. Specifically, the existing model architecture and optimization methods are not well-suited to low-power edge devices, the agricultural tasks such as weed detection require high accuracy, short inference latency, and low cost. Although there are automated tuning methods available, the search space is extremely large, using existing models for compression and optimization greatly wastes tuning resources. In this article, we propose a lightweight PAM-FOG net based on weed distribution and projection mapping. More significantly, we propose a novel model compression optimization method to fit our model. Compared with other models, PAM-FOG net runs on smart weeding robots supported by edge devices, and achieves superior accuracy and high frame rate. We effectively balance model size, performance and inference speed, reducing the original model size by nearly 50%, power consumption by 26%, and improving the frame rate by 40%. It shows the effectiveness of our model architecture and optimization method, which provides a reference for the future development of deep learning in intelligent agriculture.
MCRPL: A Pretrain, Prompt, and Fine-tune Paradigm for Non-overlapping Many-to-one Cross-domain Recommendation
Authors: Liu Hao , Guo Lei , Zhu Lei , Jiang Yongqiang , Gao Min , Yin Hongzhi
Published: January 2024

Cross-domain Recommendation is the task that tends to improve the recommendations in the sparse target domain by leveraging the information from other rich domains. Existing methods of cross-domain recommendation mainly focus on overlapping scenarios by assuming users are totally or partially overlapped, which are taken as bridges to connect different domains. However, this assumption does not always hold, since it is illegal to leak users’ identity information to other domains. Conducting Non-overlapping MCR (NMCR) is challenging, since (1) the absence of overlapping information prevents us from directly aligning different domains, and this situation may get worse in the MCR scenario, and (2) the distribution between source and target domains makes it difficult for us to learn common information across domains. To overcome the above challenges, we focus on NMCR and devise MCRPL as our solution. To address Challenge 1, we first learn shared domain-agnostic and domain-dependent prompts and pre-train them in the pre-training stage. To address Challenge 2, we further update the domain-dependent prompts with other parameters kept fixed to transfer the domain knowledge to the target domain. We conduct experiments on five real-world domains, and the results show the advance of our MCRPL method compared with several recent SOTA baselines. Moreover, our source codes have been publicly released.

1
Letter from the Chair
Authors: Murdock Vanessa
Published: January 2024

Greetings SIGIR Members! SIGIR in Taipei was a success. A big thank you to the general chairs
Hsin-Hsi Chen, Wei-Jou (Edward) Duh
, and
Hen-Hsen Huang
, for putting on a great conference, in a beautiful venue. Thank you also to the Program Chairs
Makoto Kato, Josiane Mothe
and
Barbara Poblete
for the excellent technical programming! We would like to congratulate the Best Paper winners
Maik Fröbe, Jan Heinrich Reimer, Sean MacAvaney, Niklas Deckers, Simon Reich, Janek Bevendorff, Benno Stein, Matthias Hagen
, and
Martin Potthast
for their paper
The Information Retrieval Experiment Platform.
We would also like to congratulate
Alireza Salemi, Juan Altmayer Pizzorno
, and
Hamed Zamani
whose paper
A Symmetric Dual Encoding Dense Retrieval Framework for Knowledge-Intensive Visual Question Answering
won the Best Student Paper Award at SIGIR this year. Preparations for SIGIR 2024 in Washington DC are well underway, as preparations for SIGIR 2025 in Padua are beginning.
Tasks, Copilots, and the Future of Search: A Keynote at SIGIR 2023
Authors: White Ryen W.
Published: January 2024

Search is far from being a solved problem. While search engines may cope well with simple tasks, searchers and systems struggle as task complexity increases. Task is central to the search process, motivating the search and driving search behavior. Complex search tasks require more than support for rudimentary fact finding or re-finding. Various support options have been offered by search systems over time (e.g., query suggestions, contextual search) to help search engine users more effectively tackle complex tasks. The recent emergence of generative artificial intelligence (AI) and the arrival of assistive agents, or
copilots
, based on this technology, has the potential to offer further assistance to searchers, especially those engaged in complex tasks. The implications from these advances for the design of intelligent systems and for the future of search itself are significant. This overview of the keynote that I gave at the 2023 ACM SIGIR Conference introduces AI copilots and briefly presents some of the challenges and opportunities for researching, developing, and deploying search copilots.

Date
: 26 July 2023.
Report on the 13th Workshop on Temporal Web Analytics (TempWeb 2023) at WWW 2023
Authors: Spaniol Marc , Baeza-Yates Ricardo , Alonso Omar
Published: January 2024

TempWeb is an established Workshop (series) with a long-standing tradition as a co-located event at The Web Conference. Considering the constantly evolving Web as a primary object of research, TempWeb provides a platform to present longitudinal studies on the Web (structure), its contents, and its communities, etc. by aiming at the investigation of infrastructures, scalable methods, and innovative software for aggregating, querying, and analyzing heterogeneous data at Web scale. Since longitudinal aspects in Web analytics is becoming more and more inter- and transdiciplinary relevant for analysts from various domains, the studies, tools, and demonstrations are not only limited to computer science, but also open to sociology, marketing, environmental studies, politics, etc., to name just a few. As such, TempWeb has developed as a forum for a community from academia and industry covering temporal Web analytics at all levels of granularity and across various disciplines.

Date
: 1 May 2023.

Website
: http://temporalweb.net/.
Report on the 1st Workshop on Generative Information Retrieval (Gen-IR 2023) at SIGIR 2023
Authors: Bénédict Gabriel , Zhang Ruqing , Metzler Donald , Yates Andrew , Deffayet Romain , Hager Philipp , Jullien Sami
Published: January 2024

The first edition of the workshop on Generative Information Retrieval (Gen-IR 2023) took place in July 2023 in a hybrid fashion, co-located with the ACM SIGIR Conference 2023 in Taipei (SIGIR 2023). The aim was to bring information retrieval researchers together around the topic of generative AI that gathered attention in 2022 and 2023 with large language models and diffusion models. Given the novelty of the topic, the workshop was focused around multi-sided discussions, namely panels and poster sessions of the accepted proceedings papers. Two main research outcomes are the proceedings of the workshop1 and the potential research directions discussed in this report.

Date
: 27 July 2023.

Website
: https://coda.io/@sigir/gen-ir.
Report on the 11th International Workshop on News Recommendation and Analytics (INRA 2023) at ACM RecSys 2023
Authors: Kille Benjamin , Lommatzsch Andreas , Özgöbek Özlem , Liu Peng , Zhang Lemei , Eide Simen
Published: January 2024

News remains a challenging domain for personalization. INRA'23 allowed experts and practitioners to get together and discuss recent trends and future directions. Peer review selected six contributions for presentation covering a wide array of topics including beyond accuracy evaluation, the use of large language models, misinformation, and emotions in news.

Date
: 18 September 2023.

Website
: https://research.idi.ntnu.no/NewsTech/INRA/.
Report on the 14th Conference and Labs of the Evaluation Forum (CLEF 2023): Experimental IR Meets Multilinguality, Multimodality, and Interaction
Authors: Aliannejadi Mohammad , Arampatzis Avi , Faggioli Guglielmo , Ferro Nicola , Giachanou Anastasia , Kanoulas Evangelos , Li Dan , Tsikrika Theodora , Vlachos Michalis , Vrochidis Stefanos
Published: January 2024

This is a report on the fourteenth edition of the
Conference and Labs of the Evaluation Forum
(CLEF 2023), held on September 18--21, 2023, in Thessaloniki, Greece. CLEF was a four-day hybrid event combining a conference and an evaluation forum. The conference featured keynotes by Barbara Plank and Claudia Hauff, and presentation of peer-reviewed research papers covering a wide range of topics, in addition to many posters. The evaluation forum consisted of thirteen labs: BioASQ, CheckThat!, DocILE, eRisk, EXIST, iDPP, ImageCLEF, JokeR, LifeCLEF, LongEval, PAN, SimpleText, and Touché, addressing a wide range of tasks, media, languages, and ways to go beyond standard test collections.

Date
: 18--21 September, 2023.

Website
: https://clef2023.clef-initiative.eu/.
Report on the 10th Joint Workshop on Interfaces and Human Decision Making for Recommender Systems (IntRS 2023) at ACM RecSys 2023
Authors: Brusilovsky Peter , de Gemmis Marco , Felfernig Alexander , Lops Pasquale , Polignano Marco , Semeraro Giovanni , Willemsen Martijn C.
Published: January 2024

The 10th edition of the Joint Workshop on Interfaces and Human Decision Making for Recommender Systems was held as part of the 17th ACM Conference on Recommender Systems (RecSys), the premier international forum for the presentation of new research results, systems and techniques in the broad field of recommender systems. The workshop was organized as a hybrid event: the physical session took place on September 18th at the venue of the main conference, Singapore, with the possibility for authors to present remotely. The IntRS workshop brings together an interdisciplinary community of researchers and practitioners who share research on new recommender systems (informed by psychology), including new design technologies and evaluation methodologies, and aim to identify critical challenges and emerging topics in the field. This year we focused particularly on topics related to Human-Centered AI, Explainability of decision-making models, User-adaptive XAI systems, which are becoming more and more popular in the last years, especially in domains where recommended options might have ethical and legal impacts on users. The integration of XAI with recommender systems is crucial for enhancing their transparency, interpretability, and accountability. This topic attracted a lot of interest from the community, as demonstrated by the fact that several workshop papers proposed methods for recommendation explanations.

Date
: 18 September 2023.

Website
: https://intrs2023.wordpress.com.
Report on the 1st Workshop on Task Focused IR in the Era of Generative AI
Authors: Shah Chirag , White Ryen W.
Published: January 2024

Search and recommender systems should prioritize support for user tasks over support for individual queries or actions. To that end, the Information Retrieval (IR) community has spent decades trying to understand users' tasks and their contexts, and how to best assist users in making progress toward completing them. The recent advancements in generative artificial intelligence (AI) have drastically shifted the landscape of task-focused IR. Users can now express not only their queries and questions, but actual information needs, tasks, and goals in natural language to an AI system and receive not just results, but also answers in natural language that are generated specifically for them. This new paradigm raises many interesting questions, opportunities, and challenges. We brought together a group of highly motivated students and scholars in a two-day workshop on the Microsoft campus in Redmond to discuss these issues, learn from each other, and envision a new future for task-focused IR and information access more broadly.

Date
: 28--29 September 2023.

Website
: https://ir-ai.github.io.
Report on the 21st Dutch-Belgian Information Retrieval Workshop (DIR 2023)
Authors: Anand Avishek , Pera Maria Soledad , Heuss Maria , V Venktesh , Corsi Matteo
Published: January 2024

This year, the 21st edition of the Dutch-Belgian Information Retrieval Workshop (DIR), was hosted by TU Delft. Following a series of online interactions due to the COVID-19 pandemic, this edition returned to its traditional in-person format. In this report, we provide a summary of the program and discuss key insights and lessons learned gleaned from the event.

Date
: 27 November 2023.

Website
: https://dir2023.github.io/DIR2023/.
Metric Optimization and Mainstream Bias Mitigation in Recommender Systems
Authors: Li Roger Zhe
Published: January 2024

Recommender Systems have drawn extensive attention in recent decades. The most important factor to make a recommender succeed is user satisfaction, which is largely reflected by the recommendation accuracy. In accordance, this thesis dives into recommendation accuracy from two different perspectives that, unfortunately, are at tension with each other: achieving the maximum overall recommendation accuracy, and balancing that accuracy among all users.

The first part of this thesis focuses on maximizing the overall recommendation accuracy Li et al. [2021a]. This accuracy is usually evaluated with some user-oriented metrics tailored to the recommendation scenario. However, recommendation models could be trained to maximize some other generic criteria that do not necessarily align with the criteria ultimately captured by the metric above. Recent research usually assumes that the metric used for evaluation is also the metric used for training. We challenge this assumption, mainly because some metrics are more informative than others. Indeed, we show that models trained via the optimization of a loss inspired by Rank-Biased Precision (RBP) tend to yield higher accuracy, even when accuracy is measured with metrics other than RBP. However, the superiority of this RBP-inspired loss stems from further benefiting users who are already well-served, rather than helping those who are not.

This observation inspires the second part of this thesis, where our focus turns to helping nonmainstream users, who are difficult to recommend to either because of the lack of data for effective modeling or a niche taste that is hard to match similar users.

Our first effort consists in using side data, beyond the user-item interaction matrix, so that users and items are better represented. This will be of benefit especially for the non-mainstream users, for which the user-item matrix alone is ineffective. We propose Neural AutoEncoder Collaborative Filtering (NAECF) Li et al. [2021b], an adversarial learning architecture that, in addition to maximizing the recommendation accuracy, leverages side data to preserve the intrinsic properties of users and items and show that NAECF leads to better recommendations specially for non-mainstream users, while at the same time there is a marginal loss for the mainstream ones.

Our second effort Li et al. [2023] consists in explicitly focusing more on non-mainstream users in a recommendation model. In particular, we propose a mechanism based on cost-sensitive learning that weighs users according to their mainstreamness, so that they get more attention during training. The result is a recommendation model tailored to non-mainstream users, that narrows the accuracy gap, and again at negligible cost to the mainstream users.

Awarded by
: Delft University of Technology, Delft, The Netherlands on 14 November 2023.

Supervised by
: Alan Hanjalic and Julián Urbano.

Available at
: https://doi.org/10.4233/uuid:235a5f5c-5e18-4e67-a8e6-84a7e310db12.
Optimized Charge Dynamics of Sr2Fe2O5/rGO Composite Electrodes: Redefining Supercapacitor Efficiency
Authors: Bilal Muhammad , Ahmad Farooq , Zawar Sidra , Waqas Umer , Khan Muhammad Ahmed , Ramay Shahid M. , Atiq Shahid
Published: January 2024

Mixed transition metal oxides have become highly effective electrode materials due to their remarkable cyclic stability and improved capacitance, which has consequently led them to display exceptional electrochemical performance. In this work, a facile synthesis of Sr2Fe2O5/reduced graphene oxide composites was carried out through a solvothermal technique to investigate the electrochemical performance. X-ray diffraction patterns confirmed the cubic perovskite structure of Sr2Fe2O5. The morphological analysis revealed well-defined grains with sharp boundaries, having uniformly distributed porous regions. The stoichiometric ratios of sample compositions were confirmed using elemental analysis. The electrolyte employed for the electrochemical characterizations was 1 M potassium hydroxide (KOH), carried out using three-electrode cell. The composite sample Sr2Fe2O5/15% reduced graphene oxide showed excellent electrochemical performance compared to other samples. It demonstrated a maximum specific capacitance of ∼360.29 F g−1 at a lower scan rate of 0.01 V s−1, as observed using cyclic voltammetry. The electrochemical analysis of this electrode through the GCD system has a high value of capacitance ∼1110 F g−1 followed by a high energy density value of ∼32.76 Wh kg−1, respectively. The Nyquist plot revealed less barrier to charge transfer. Therefore, the comprehensive investigation of this electrode material suggested that this as-synthesized composite could be utilized in high-performance energy storage devices.
Inclusion Properties for Classes of p-Valent Functions
Authors: Munasser B. M. , Mostafa A. O. , Sultan T. , EI-Sherbeny Nasser A. , Madian S. M.
Published: January 2024

Making use of a differential operator, which is defined here by means of the Hadamard product, we introduce classes of p-valent functions and investigate various important inclusion properties and characteristics for these classes. Also, a property preserving integrals is considered.
Dental Biopolymer Composites with Antibiotics, Bisphosphonate, and Hydroxyapatite for Possible Use in Bone Tissue Regeneration
Authors: Budiul Mihaela Maria , Vlase Gabriela , Negru Daniel , Okolišan Dorinel , Bradu Ionela-Amalia , Tăşală Alexandra , Pahomi Alexandru , Vlase Titus , Jumanca Daniela , Galuscan Atena , Sfirloaga Paula , Carabă Nicoleta , Popescu Roxana , Matichescu Anamaria
Published: January 2024

The aim of the present study was to formulate new variants of synthetic and animal-source bone materials coated with different biopolymers, containing antibiotics (ampicillin and oxacillin) and alendronate drugs. Validation consists in establishing mixtures that do not present interactions between components. These materials should act as a drug delivery system alongside the bone base. Natural polymers such as chitosan, alginate, and kappa-carrageenan have been shown to be optimal materials for drug delivery due to their intrinsic biocompatibility. Binary, ternary, and quaternary mixtures between components are analyzed by FT-IR spectroscopy, UV-Vis analysis, thermogravimetry (TGA), and scanning electron microscopy (SEM). The analysis led to the validation of materials suitable for the controlled release of active substances, which have the greatest chance of increasing the speed of bone regeneration, as well as helping in the local administration of antibiotics, which currently must be administered in the form of oral formulations or an injection. According to the FTIR, thermogravimetry, UV-Vis, SEM, and cytotoxicity tests performed in this study, it can be said that it is quite easy to obtain materials that can be used in dental practice that facilitate bone reconstruction through local treatment. At the same time, it was found that both active substances can be incorporated into the material together with Alg and Chit, thus limiting the adverse effects and maximizing the local beneficial effects.
A New Sine-Based Probabilistic Approach: Theory and Monte Carlo Simulation with Reliability Application
Authors: Heydari Tahereh , Zare Karim , Shokri Soheil , Khodadadi Zahra , Almaspoor Zahra
Published: January 2024

Data modeling is a very crucial stage for decision making in applied sectors. Probability distributions are considered important tools for decision making. So far, numerous probability distributions have been developed and implemented. Most of these distributions are developed by introducing from one to eight additional parameters. Sometimes, the addition of new parameters leads to re-parameterization problems. To avoid such issues, we introduce a novel probabilistic approach. The proposed approach may be termed as a new weighted sine-G method. The beauty and key advantage of the new weighted sine-G method are that it has no additional parameters. Through using the new weighted sine-G method, a new weighted sine-Weibull distribution is introduced, which is a modification of the Weibull distribution. The estimators of the new model are also derived. Furthermore, a simulation study is carried out to evaluate the estimators of the new weighted sine-Weibull distribution. Finally, a practical application from the reliability sector is considered to evaluate the new weighted sine-Weibull distribution. Based on certain decision tools, it is observed that the proposed model is the best competing distribution for applying it in the reliability sector.
Data from Mouse Tissues that Undergo Neoplastic Progression after K-Ras Activation Are Distinguished by Nuclear Translocation of phospho-Erk1/2 and Robust Tumor Suppressor Responses
Authors: Parikh Neha , Shuck Ryan L. , Nguyen Thuy-Ai , Herron Alan , Donehower Lawrence A.
Published: January 2024

Abstract
Mutation of K-Ras is a frequent oncogenic event in human cancers, particularly cancers of lungs, pancreas, and colon. It remains unclear why some tissues are more susceptible to Ras-induced transformation than others. Here, we globally activated a mutant oncogenic K-Ras allele (K-RasG12D) in mice and examined the tissue-specific effects of this activation on cancer pathobiology, Ras signaling, tumor suppressor, DNA damage, and inflammatory responses. Within 5 to 6 weeks of oncogenic Ras activation, mice develop oral and gastric papillomas, lung adenomas, and hematopoietic hyperproliferation and turn moribund. The oral, gastric, and lung premalignant lesions display activated extracellular signal–regulated kinases (Erk)1/2 and NF-κB signaling as well as activated tumor suppressor and DNA damage responses. Other organs such as pancreas, liver, and small intestine do not exhibit neoplastic progression within 6 weeks following K-RasG12D activation and do not show a potent tumor suppressor response. Even though robust Erk1/2 signaling is activated in all the tissues examined, the pErk1/2 distribution remains largely cytoplasmic in K-RasG12D–refractory tissues (pancreas, liver, and intestines) as opposed to a predominantly nuclear localization in K-RasG12D–induced neoplasms of lung, oral, and gastric mucosa. The downstream targets of Ras signaling, pElk-1 and c-Myc, are elevated in K-RasG12D–induced neoplastic lesions but not in K-RasG12D–refractory tissues. We propose that oncogenic K-Ras–refractory tissues delay oncogenic progression by spatially limiting the efficacy of Ras/Raf/Erk1/2 signaling, whereas K-Ras–responsive tissues exhibit activated Ras/Raf/Erk1/2 signaling, rapidly form premalignant tumors, and activate potent antitumor responses that effectively prevent further malignant progression. Mol Cancer Res; 10(6); 845–55. ©2012 AACR.
Data from TLE1 Is an Anoikis Regulator and Is Downregulated by Bit1 in Breast Cancer Cells
Authors: Brunquell Chris , Biliran Hector , Jennings Scott , Ireland Shubha Kale , Chen Renwei , Ruoslahti Erkki
Published: January 2024

Abstract
TLE1 is a Groucho-related transcriptional repressor protein that exerts survival and antiapoptotic function in several cellular systems and has been implicated in the pathogenesis of cancer. In the present study, we found that TLE1 is a regulator of anoikis in normal mammary epithelial and breast carcinoma cells. The induction of apoptosis following loss of cell attachment to the extracellular matrix (anoikis) in untransformed mammary epithelial MCF10A cells was associated with significant downregulation of TLE1 expression. Forced expression of exogenous TLE1 in these cells promoted resistance to anoikis. In breast cancer cells, TLE1 expression was significantly upregulated following detachment from the extracellular matrix. Genetic manipulation of TLE1 expression via overexpression and downregulation approaches indicated that TLE1 promotes the anoikis resistance and anchorage-independent growth of breast carcinoma cells. Mechanistically, we show that TLE1 inhibits the Bit1 anoikis pathway by reducing the formation of the proapoptotic Bit1-AES complex in part through sequestration of AES in the nucleus. The mitochondrial release of Bit1 during anoikis as well as exogenous expression of the cytoplasmic localized Bit1 or its cell death domain induced cytoplasmic translocation and degradation of nuclear TLE1 protein. These findings indicate a novel role for TLE1 in the maintenance of anoikis resistance in breast cancer cells. This conclusion is supported by an immunohistochemical analysis of a breast cancer tissue array illustrating that TLE1 is selectively upregulated in invasive breast tumors relative to noninvasive ductal carcinoma in situ and normal mammary epithelial tissues. Mol Cancer Res; 10(11); 1482–95. ©2012 AACR.
Data from Repression of Malignant Tumor Progression upon Pharmacologic IGF1R Blockade in a Mouse Model of Insulinoma
Authors: Zumsteg Adrian , Caviezel Christoph , Pisarsky Laura , Strittmatter Karin , García-Echeverría Carlos , Hofmann Francesco , Christofori Gerhard
Published: January 2024

Abstract
NVP-AEW541, a specific ATP-competitive inhibitor of the insulin-like growth factor-1 receptor (IGF1R) tyrosine kinase, has been reported to interfere with tumor growth in various tumor transplantation models. We have assessed the efficacy of NVP-AEW541 in repressing tumor growth and tumor progression in the Rip1Tag2 transgenic mouse model of pancreatic β-cell carcinogenesis. In addition, we have tested NVP-AEW541 in Rip1Tag2;RipIGF1R double-transgenic mice which show accelerated tumor growth and increased tumor malignancy compared with Rip1Tag2 single-transgenic mice. Previously, we have shown that high levels of IGF-2, a high-affinity ligand for IGF1R, are required for Rip1Tag2 tumor cell survival and tumor growth. Unexpectedly, treatment of Rip1Tag2 mice with NVP-AEW541 in prevention and intervention trials neither did affect tumor growth nor tumor cell proliferation and apoptosis. Yet, it significantly repressed progression to tumor malignancy, that is, the rate of the transition from differentiated adenoma to invasive carcinoma. Treatment of Rip1Tag2;RipIGF1R double-transgenic mice resulted in moderately reduced tumor volumes and increased rates of tumor cell apoptosis. Sustained expression of IGF-2 and of the IGF-2–binding form of insulin receptor (IR-A) in tumor cells suggests a compensatory role of IR-A upon IGF1R blockade. The results indicate that inhibition of IGF1R alone is not sufficient to efficiently block insulinoma growth and imply an overlapping role of IGF1R and insulin receptor in executing mitogenic and survival stimuli elicited by IGF-2. The reduction of tumor invasion upon IGF1R blockade on the other hand indicates a critical function of IGF1R signaling for the acquisition of a malignant phenotype. Mol Cancer Res; 10(6); 800–9. ©2012 AACR.
Data from Lysophosphatidic Acid–Induced p21Waf1 Expression Mediates the Cytostatic Response of Breast and Ovarian Cancer Cells to TGFβ
Authors: Wu Jinhua , Mukherjee Abir , Lebman Deborah A. , Fang Xianjun
Published: January 2024

Abstract
Lysophosphatidic acid (LPA) is a multifunctional intercellular phospholipid mediator present in blood and other biological fluids. In cancer cells, LPA stimulates expression or activity of inflammatory cytokines, angiogenic factors, matrix metalloproteinases, and other oncogenic proteins. In this study, we showed that LPA upregulated expression of the cyclin-dependent kinase inhibitor p21Waf1 in TGFβ-sensitive breast and ovarian cancer cells, but not in TGFβ-resistant ones. We examined the possibility that LPA-induced p21 might contribute to the cytostatic response to TGFβ. In serum-free conditions, TGFβ alone induced p21 expression weakly in TGFβ-sensitive cells. Serum or serum-borne LPA cooperated with TGFβ to elicit the maximal p21 induction. LPA stimulated p21 via LPA1 and LPA2 receptors and Erk-dependent activation of the CCAAT/enhancer binding protein beta transcription factor independent of p53. Loss or gain of p21 expression led to a shift between TGFβ-sensitive and -resistant phenotypes in breast and ovarian cancer cells, indicating that p21 is a key determinant of the growth inhibitory activity of TGFβ. Our results reveal a novel cross-talk between LPA and TGFβ that underlies TGFβ-sensitive and -resistant phenotypes of breast and ovarian cancer cells. Mol Cancer Res; 9(11); 1562–70. ©2011 AACR.
FIGURE 2 from Lung Fibroblasts Take up Breast Cancer Cell-derived Extracellular Vesicles Partially Through MEK2-dependent Macropinocytosis
Authors: Wan Yuhao , Zhao Yue , Cao Minghui , Wang Jingyi , Tran Sheila V. , Song Zhixuan , Hsueh Brent W. , Wang Shizhen Emily
Published: January 2024

Human lung fibroblasts take up MDA-MB-231 EVs via dynamin- and caveolae-dependent endocytosis and macropinocytosis. A, Fibroblasts were pretreated with 80 µmol/L Dynasore or an equal volume of DMSO (as a control) for 24 hours and then incubated with 10 µg/mL EVs for 6 hours in the continuous presence of Dynasore or control (n = 3 wells per group; 5 images per well). Data are presented as mean ± SD. ***, P < 0.001. B, Cells were pretreated with 50 µmol/L EIPA, 10 µmol/L CPZ, or 200 µmol/L Genistein for 24 hours and then incubated with 10 µg/mL EVs for 6 hours in the presence of drug (n = 3 wells per group; 5 images per well). Data are presented as mean ± SD. ***, P < 0.001; ns, not significant. C, Representative images of Dynasore-, EIPA-, CPZ-, or Genistein-treated cells and untreated cells. Images were captured at 10 ×. Green, CFSE; yellow, DiI; blue, Hoechst 33342. Scale bar, 100 µm.
Role of Bupropion in the Management of Internet Gaming Disorder: A Systematic Review
Authors: Suryadarma Antonius Yansen , Trisna Irwan
Published: January 2024

This systematic review aims to summarize the role of bupropion in the management of internet gaming disorder (IGD) patients. Five electronic databases were searched without date restrictions until September 10, 2021. Four studies with a moderate risk of bias were included. Compared to escitalopram, bupropion showed better improvement in reducing addictive use of online gaming and IGD severity (low certainty). Compared with placebo or no treatment, bupropion was better in reducing addictive use of online gaming, IGD severity, and the total time of online game playing (low to moderate certainty). The combination of bupropion with cognitive behavior therapy (CBT) was superior to bupropion alone in reducing the addictive use of online gaming and the total time of online game playing (low certainty). Bupropion may be effective in improving IGD symptoms. However, there is an evident need for more extensive randomized controlled trials (RCTs) with better methodology and longer follow-up before more conclusions can be drawn.
Qualitative Study of Factors Causing Double Numbering of Medical Record Documents at Dharma Yadnya Hospital Denpasar
Authors: Ni Luhtu Rediyantini  , Purwanti Ika Setya , Widana A. A. Gde Oka
Published: January 2024

Introduction: Duplication is when two medical record numbers have the same identity or patient. Duplication or double numbering of medical records occurs because the patient's medical record file is not found when the patient comes for treatment, or the patient needs to remember to bring the Medical Index Card (MIC). This study wanted to determine the factors that cause duplication or double numbering of medical record documents. Method: Data collection was carried out by in-depth interviews, observation, and documentation using case study research with qualitative descriptive methods. The Miles and Huberman method is used in data analysis. The sample of this study amounted to 5 people with purposive sampling techniques. Results: The results of the study showed that the implementation of medical record documents in the registration section uses a computerized system, numbering system using the Unit Numbering System (UNS), alignment system using the Straight Numerical Filling (SNF) system, storage system using a Decentralized system, and the leading cause of duplication of medical record numbers at Dharma Yadnya Hospital is that when patients come for treatment often do not bring MIC or other identity cards. Conclusion: From the study results, the implementation of taking medical record documents has not followed the Standard Operational Procedure (SOP) because it has yet to implement tracers. So, tracers are recommended, and officers must be careful in carrying out health services following existing SOP regulations.
Vacuum effect of wrongful criminal justice process: The case of Indonesia
Authors: Rahmawati Erni , Dermawan Mohammad Kemal
Published: January 2024

Introduction: The victims in Indonesia who have been wrongly arrested in various phases of the criminal justice process and have accordingly experienced suffering are not yet included within the terms. The existing term does not clearly describe the officials responsible for the wrongful arrest while enforcing criminal law either. This study aims to address these problems. Method: Using literature review as a research method to explain problems regarding the terms of wrongful arrest, the study also uses critical victimology, which includes structural victimization and state crime. Results: The process of wrongful arrest in Indonesia comprised of victims who were released in the early phase of the case investigation and victims who have served their sentences. Additionally, officials in the criminal justice system, especially the police, and judges, have a significant role in attracting people into the criminal justice system and keeping them in the position of the perpetrator until the last phase, even when all the evidence point to the victim’s innocence. Conclusions: Such a characteristic can be described as a vacuum. It tends to suck the victims until the final phase despite its ability to release them in the middle of the process with the help of parties of the justice system. Given this problem, wrongful criminal justice process as a new term has emerged, which includes and explains problems not adequately addressed by the previous term. Through this term, it is expected that the victims will get more attention and receive compensation from the state.
Unveiling the Morphology of Saharan Heritage: Exploring Urban Heritage in the Algerian Sahara
Authors: Gherraz Halima , Guechi Imen , Alkama Djamel
Published: January 2024

This study is dedicated to exploring the Ksurian heritage of the Algerian Sahara, aiming to reveal the abundance and variety embedded within each ksar. Employing a comprehensive analytical approach, we meticulously examine four fundamental aspects: the urban layout, the dwellings, the materials utilized, and the construction techniques employed. To accomplish this research, extensive field visits were conducted, encompassing photography, on-site surveys, and engaging discussions with experts to gain profound insights into the distinctive characteristics of each region. Our findings unveil a remarkable and diverse heritage, exhibiting variations from one region to another, ultimately reflecting the unique traditions and capabilities of the Saharan population.
Programa BR do Mar e seus efeitos sobre a matriz de transporte e rotas inter-regionais no Brasil
Authors: Barbosa Márcio Nora , Azevedo André Filipe Zago de , Massuquetti Angélica , Gurgel Angelo Costa
Published: January 2024

Este artigo investiga os efeitos que o Programa BR do Mar, incentivo à cabotagem, poderá exercer sobre a matriz de transportes de cargas e nas rotas inter-regionais do país. Para tanto, foi desenvolvido um Modelo de Equilíbrio Geral Computável, denominado PAEG-TLOG, com base no GTAP em sua versão 10. Os resultados indicam que a matriz de transporte inter-regional obtém um crescimento da participação da cabotagem, representando uma redução de, aproximadamente, 410 mil caminhões nas estradas em longas distâncias, reduzindo os acidentes, os custos com roubos e avarias e gerando menores níveis de poluição.
Oferta e demanda de exportação da carne bovina brasileira para a Ásia no período de 2002 a 2019
Authors: Vilela Marina de Paula , Barros Geraldo Sant'Ana de Camargo , Adami Andreia Cristina de Oliveira
Published: January 2024

Neste artigo, são estimados os determinantes da demanda e oferta de exportação da carne bovina desossada congelada brasileira para a Ásia entre 2002 a 2019, aplicando-se os métodos de mínimos quadrados em dois e três estágios. Para identificação de problemas de autocorrelação e heterocedasticidade utilizou-se o procedimento de Newey-West. Após essacorreção, a estimativa do efeito de restrições sanitárias não se mostrou significativa. Já os efeitos dos preços da carne bovina dos países concorrentes, preço do produto brasileiro no mercado asiático, peso médio das carcaças, taxa de câmbio e renda se mostraram importantes para explicar o desempenho das exportações brasileiras.
A noção de poema em prosa, por Meschonnic
Authors: Paixão Fernando
Published: January 2024

Por se tratar de um gênero híbrido, o poema em prosa costuma ser um tema de controvérsia entre os críticos; enquanto alguns o assumem como um modelo próprio, historicamente consolidado ao longo do século XX, outros refutam essa identidade. O presente artigo visa contribuir com o debate, ao levantar as ideias dede Henri Meschonnic sobre o assunto, tendo em vista seu entendimento da noção de ritmo. O autor francês sugere em seus escritos que o gênero novo implica uma “outra liturgia”, em comparação com a poesia e a prosa. E aponta alguns caminhos para o entendimento dessa expressão heterogênea.
Traduzir o poema Henri Meschonnic
Authors: Mendes Rafael Costa
Published: January 2024

Este artigo propõe uma reflexão teórico-prática sobre os mecanismos que são mobilizados na atividade de tradução para o português da obra poética de Henri Meschonnic (1932-2009). Nosso objetivo é observar a continuidade que existe entre a escrita de poemas e os ensaios teóricos e traduções bíblicas realizados pelo poeta-tradutor francês, para então, por meio de uma experimentação tradutória teórico-prática, continuar Meschonnic no Brasil. Nesse sentido, o estudo será desenvolvido em torno de três etapas. A primeira trata sobre a situação da obra de Meschonnic no Brasil. A segunda aborda uma poética do contínuo que caracteriza o estilo e o pensamento do poeta-tradutor. A terceira consiste na realização de uma experiência teórico-prática com a tradução de trechos de poemas de Meschonnic para a língua portuguesa. O conjunto de reflexões aqui desenvolvido busca fornecer meios para integrar a obra poética do poeta-tradutor no amplo movimento que faz continuar Meschonnic no Brasil.
Historicidade – contínuo/descontínuo dança-história na poesia sufi
Authors: Yunis Leandra
Published: January 2024

O artigo aborda o sentido da historicidade/alteridade em Henri Meschonnic em relação a algumas teorias da História que se constelam na perspectiva de um estudo sobre a tradução do aspecto dançante na poesia do místico sufi Jalal Uddin Rumi, do século XIII.
Je traduis toujours dans une autre langue, je ne suis l’hôte d’aucune: le thème et l’éthique
Authors: Ferreira Alice Maria Araújo
Published: January 2024

La direction en traduction organise la plupart des discours sur l’éthique qui s’articule souvent autour de la relation national/étranger et de la position de celui qui accueil, c’est-à-dire de celui qui traduit l’étranger dans sa langue. En ce sens, l’éthique se présente comme un rapport de soi envers l’autre, de la traduction envers l’original, une hospitalité, une fidélité. Henri Meschonnic quant à lui, analysant l’éthique à l’instance du sujet, la définit dans un double rapport à soi et à l’autre, qui émerge du rapport des sujets au vivre. Ce double rapport comparait se manifeste dans notre essai, d’une part, dans le thème, puisque dans cette direction l’original et l’altérité ne sont pas du même côté, et d’autre part, chez le sujet e/i-migré qui ne sépare pas ce que la distance a éloigné. Nous partons d’un récit personnel de migration et traduction qui met en scène les rapports affectifs que le sujet é/i-migré entretient avec les langues qui lui servent à vivre. Dans un second temps, l’éthique du traduire étant liée à la conception même de traduction comme relation, c’est ce rapport qu’il nous faudra questionner, ou plutôt les rapports. Peut-on traduire dans un double rapport éthique lié à l'altérité et à l'original qui, cette fois, ne sont pas du même côté ? Ou encore, comment (car c'est toujours un mode) être éthique avec soi-même et avec l'autre tel que les deux versants se constituent comme sujet par/dans la relation?
As metamorfoses em uma narrativa amazônica
Authors: Lacerda Gabriela Ismerim
Published: January 2024

O presente artigo pretende, através da narrativa “Epépim”, coletada, transcrita e publicada por Barbosa Rodrigues em Poranduba amazonense, observar dois tipos de metamorfoses: “transformação em estrelas” e “fragmentos corporais metamorfoseados” para, então, refletir sobre a importância das metamorfoses para a literatura indígena amazônica.