bluuebunny/crossref_metadata_2025 huggingface dataset:
INTEGRATIVE MEDICINE THROUGH ISLAMIC PERSPECTIVE IN RESPECTING PANDEMIC COVID-19
Authors: Meity Elvina
Published: March 2022

One of the problems in the world today is the outbreak of the coronavirus pandemic case. The case of this pandemic outbreak also cannot be separated from the problems known to Muslims. Overall, Al-Quran and al-Hadith explain about many stories that we might be able to take the event of ibrah. Islam's perfection has provided many solutions to various kinds of problems that arise by a Muslim, including the coronavirus pandemic, which is of considerable concern to humans worldwide.

Muslim needs to have his own perspective in responding to this coronavirus outbreak's pandemic incident. So that we can do our best to overcome the pandemic case of the coronavirus outbreak by "making peace" with microorganisms, which are also God's creatures, we can contemplate answering questions related to this, for example, why is this outbreak the case of the current pandemic? The perfect guide to life, namely the book of Allah Al Quran, already has the answer.
Pemberdayaan Usaha Garam Rakyat Dalam Meningkatkan Kualitas Garam Menggunakan Teknik Geomembran LDPE di Kelurahan Talise Kota Palu
Authors: Suriawanto Nelky , Nurhayati  , Muhammad Fadhli Wendy , M. Syahril  , Nivita Nanda Gabrela
Published: March 2022

Salt is an important commodity that is widely used from consumption to industry. Talise Village is the only salt-producing village in Palu City because the area is mostly located on the coast of Palu Bay. LDPE (Low Density Polyethylene) geomembrane technology is an empowerment program focused on increasing the production and quality of salt products and improving welfare by increasing the income of salt farmers. The purpose of this activity is to apply LDPE geomembrane technology to salt farmer groups in Talise in producing and improving the quality of SNI-standard salt as consumption salt and increasing awareness of salt farmers to use technology in managing their salt ponds. The method used is the stages of socialization, pre-production and production. The results of this activity program, namely the use of LDPE geomembrane technology on crystal tables, have increased the quantity and quality of salt for salt farmers in Talise Village, Mantikulore District, Palu City, Central Sulawesi. In addition, crop yields have increased threefold and harvest time is 3 to 4 days faster than conventional methods.
Manajemen Bank Sampah: Menjadikan Sampah Bernilai Ekonomi Bagi Masyarakat Pondok Pesantren
Authors: Nurika Globila , Putra Dewa Ngakan Gde Wahyu Mahatma , Niajeng Novta Dwi Nafisah  , Rifdul Basied
Published: March 2022

The Nurul Jadid Islamic Boarding School has a problem with the generation of plastic cup waste from drinks. So far, the waste is only collected and burned. The land/building resources for the waste bank and the existing human resources are sufficient to carry out waste bank activities. However, this condition is not supported by sufficient knowledge and skills in implementing waste management activities through waste banks. Therefore, it is necessary to have community service activities in the form of education, training, and assistance to the managers of Islamic boarding schools and the community in the environment around Islamic boarding schools to carry out waste management activities with a waste bank system. This community service activity is carried out in 3 stages, namely situation analysis partner conditions, implementation of interventions, and evaluation activities. Educational activities showed an increase in participants' knowledge about waste management with the waste bank system by 10,938 points. The training activities showed an increase in the ability of participants to carry out waste bank management activities. Assistance activities for the establishment of a waste bank system which show that the managers of Islamic boarding schools have been able to develop a waste bank organizational system and waste bank management flow. It can be concluded that this community service activity is a very strategic effort in order to prepare participants to carry out activities in waste management starting from the source and making waste have economic value.
PENGARUH MOTIVASI, BUDAYA ORGANISASI, LINGKUNGAN KERJA, DAN KEPUASAN KERJA TERHADAP KINERJA GURU PADA SMA SE-KOTA JUANG BIREUEN
Authors: Saifuddin Saifuddin
Published: March 2022

This research was conducted on high school teachers in Physical Education in Bireuen District, with the aim being a). To find out the magnitude of the influence of the Principal's Leadership on teacher motivation in Physical Education in high schools throughout Bireuen Regency; b). To find out the magnitude of the influence of organizational culture on teacher motivation in Physical Education in high schools throughout Bireuen Regency; c). To find out the magnitude of the effect of financial compensation on the motivation of teachers in Physical Education in high schools throughout Bireuen Regency; and D). To find out the simultaneous influence of the Principal's leadership, organizational culture, and Financial Compensation on the motivation of teachers in Physical Education in the Bireuen District. This research is in the form of quantitative research with a survey of 60 high school Physical Education teachers in the Bireuen Regency, by collecting data through a questionnaire. And the method of data analysis with statistics with the path analysis approach. The results showed that 1). there is an influence of the Principal's Leadership factors on the motivation of high school Physical Education teachers in the Bireuen Regency, which is equal to 35.16%. 2). It also proves the influence of organizational culture factors, namely school culture on the motivation of high school Physical Education teachers in the Bireuen Regency, which is 18.46%. Bireuen, which is 13.81%. 4). The results of the analysis of the value of the coefficient of determination explain that the contribution of the factors of Principal Leadership, Organizational Culture and Financial Compensation to the Physical Education Motivation of 67.4%.
Implikasi Manajemen Program Bahasa Arab dalam Mencetak Lulusan Unggul
Authors: Shobirin Abdurrahman , Hilmi Danial
Published: March 2022

Good program management refers to each function that has a role in improving the quality and quantity of the program. From some of its functions can have positive implications on the development of students of Arabic in accordance with the vision and mission set by an institution. Madrasah Aliyah Muhammadiyah 1 Plus Malang has several Arabic programs that can support student achievement and the program is packaged in an educational, constructive, and productive management. This study uses a descriptive qualitative approach to look for implications of the functions of Arabic program management consisting of planning, organizing, implementing, controlling, and evaluating. From several implications it was found that the terminology and commitment of Madrasah Aliyah Muhammadiyah 1 Plus Malang to the Arabic language program was able to deliver its graduates to become excellent and competent graduates to compete in the Arabic language field.
Upaya Peningkatan Mutu Pendidikan Agama Islam: Problematika dan Solusi
Authors: Jadidah Amatul
Published: March 2022

Education is a means in building the character of the nation in building a highly civilized society, where Islamic Religious Education is an important part.. For this reason, efforts to improve the quality of religious education are important to overcome the problems. The purpose of this study was to find out the problems of implementing Islamic religious education and how to improve the quality of education at Madrasah Ibtidaiyah Al Hikmah in Wringinanom, Poncokusumo District, Malang Regency. In this study, the researcher uses a qualitative type, which emphasizes natural descriptions, and data collection or phenomena collection is carried out from reasonable circumstances. Therefore, researchers are directly involved in the field. From the results of the study, there were several problems found, namely: low cognitive abilities of students; commitment, quality and competence of educators that need to be improved; The lack of understanding of educators about the 2013 curriculum; lack of cooperation between a small number of parents and educators and limited infrastructure. Efforts to overcome these problems, madrasas are carried out in several ways: for students, providing educational sanctions, forming student group work, discussions between students in class, and providing additional hours. For educators, participating in seminars and workshops. For the curriculum, by increasing the socialization of the implementation of the 2013 curriculum. For management, it seeks to increase the involvement between the guardians of students and the community in an effort to improve quality, through meetings. For facilities and infrastructure, the school will seek the realization of facilities and infrastructure that do not yet exist, such as libraries.
Evaluasi Pemanfaatan E-Learning dalam Proses Pembelajaran Distance Learning di SMP IIBS Al Maahira Malang
Authors: Rauf Abdur , Amin Auliatul
Published: March 2022

Selama pandemi berlangsung, mayoritas kegiatan pembelajaran diarahkan menggunakan e-learning, termasuk dalam pembelajaran bahasa Arab. Pemanfaatan e-learning membutuhkan evaluasi untuk perbaikan kedepannya. Penelitian dilakukan untuk mengevaluasi pemanfaatan e-learning pada proses belajar siswa di SMP IIBS AL MAAHIRA PUTRI Malang pada saat pandami covid berlangsung, terutama dalam hal belajar bahasa Arab. Penelitian ini dilakukan kepada seluruh siswa kelas VII  SMP IIBS AL MAAHIRA PUTRI Malang. Metode yang digunakan dalam penelitian ini adalah kuantitatif deskriptif, dengan teknik pengumpulan data menggunakan angket yang disebarkan melalui Google form. Hasil evaluasi menunjukkan bahwa mayoritas siswa lebih suka menggunakan google meet, dengan alat laptop. Meski berupa distance learning, pembelajaran tetap dapat efektif, di mana 77,6% siswa tetap antusias mengerjakan tugas dari guru. Mayoritas siswa tetap lebih menyukai pembelajaran tatap muka. Hasil evaluasi ini berimplikasi kepada pendidik agar dapat membuat rancangan belajar yang menarik, kreatif serta inovatif, agar pembelajaran jarak jauh tetap bisa efektif.
Analisis Penggunaan E-Learning Madrasah sebagai Media Pembelajaran Bahasa Arab di MTsN 2 Kota Surabaya di Era Pandemi Covid-19
Authors: Musyarrofah Hamdatul , Syarifiyah Hilma Nailis , Bachtiar Muhammad Anis
Published: March 2022

The implementation of 4C (Critical Thinking, Communication, Collaboration, Creativity) in the learning process is vital in order to prepare students for the 21st century (Supriano, 2019). In this era which the learning process conducts online, the teachers may still emphasize those values through kinds of questions served especially through e-learning madrasah. Thus, the objectives of this study are to be a reference for the other teachers by exploring the kinds of questions in learning Arabic, also give suggestions or even convey to certain parts so that a revision of e-learning madrasah will be conducted by analyzing the obstacles. Applying descriptive qualitative method, the researchers assume that through the futures of e-learning madrasah the teachers provide PPT/PDF, multiple choices, short answer and essay questions for maharah qiro’ah (reading skill), listening to a video/audio for maharah istima’ wa kalam (listening and speaking skills), fill-in-the-blank, short answer questions as well as asking students to create a simple essay for maharah kitabah (writing skill). Nevertheless, the Arabic font in e-learning madrasah and the learning schedule which is not specific and fixed become the obstacles.
The History and Prospects of Overseas GMP Inspection in China
Authors: Sun Jing-lin , Yu Bo-yang
Published: March 2022

Carrying out the overseas GMP (Good Manufacturing Practices) inspection is a key responsibility of the National Regulatory Agency to supervise the imported pharmaceutical products. And it’s also an important measure to maintain the safety of the pharmaceutical products used by the public. In April 2011, China began to implement the pilot work of overseas GMP inspection. Through exploration and summary, a complete set of inspection procedures and systems have been formed. In this paper, the development history of China's overseas GMP inspection is reviewed, the inspection process and the treatment of inspection results are compared with the US FDA, the EU, WHO and so on. This paper analyzes the numbers, countries and types of products in the overseas GMP inspections, which carried out by China in the past decade, makes a statistical analysis of the observations found in the inspections, discusses the areas where the observations are concentrated, and focuses on the areas where the critical observations are concentrated. Finally, the trend of overseas GMP inspection in the future is prospected.
THE RISKS OF EXPOSURE TO NATURAL RADIATIONS INDUCED HYDROTHERMAL ALTERATION SITES: CASE OF CANCA SITE
Authors: VURAL Alaaddin
Published: March 2022

The main purpose of this study is to investigate the risk of exposure of natural radiation in areas with intensive alteration development, using various methods. As a case study, Canca hydrothermal alteration site located on the west-southwest of Gümüşhane, Northeast of Turkey, was selected. Above two hundred soil samples were obtained from the Canca (Gümüşhane, Türkiye) hydrothermal alteration site and analyzed for some radioisotope elements, such as, potassium (40K), uranium 238U and thorium (232Th) by ICP-AES (Inductively Coupled Plasma-Atomic Emission Spectrometry) and ICP-MS (Inductively Coupled Plasma-Mass Spectrometry). The distributions of the activities of the radioactive elements in examined soil samples belonging to the Canca field were assessed with the help of some parameters and compared the global average concentrations of those elements. The obtained results for those elements are generally for lots of sample locations greater than the global average values of them. This study conducted in the context of the Canca (Gümüşhane, Türkiye) hydrothermal alteration site showed that the hydrothermal alteration areas should be examined for the risk of exposure to radiation.
TURKISH SOCIETY'S ATTITUDE TO VIOLENCE AGAINST WOMEN
Authors: Zıvdır Pelin , ATEŞEYAN Yasemin , ÖZCANARSLAN Neslihan
Published: March 2022

The aim of this research is to determine the attitudes of women and men towards violence against women. This cross-sectional study was carried out on May-September 2021 with the participation of 454 people aged between 19-60 who could read and write, use a smart phone, had no visual impairment and agreed to participate in the study. The data were collected using the Descriptive Characteristics Information Form prepared by the researchers and the Attitude Scale towards Violence Against Women prepared by Gömbül (1998). The data obtained in the research were analyzed in the SPSS 25.0 statistical package program. It was determined that 37.4% of the participants were between the ages of 18-25, 78% were women, 51.8% were undergraduates, 53.1% were single, and 58.6% were working. In the study, the total score average of the scale was found to be significantly higher for those who consider arranged marriage more appropriate, those who think that one can commit violence unintentionally out of anger, and those who see violence as partly a means of discipline and acceptance (p<0.05). The participants' attitudes towards violence against women were below the average. However, it is observed that there is a traditionalist point of view in the results of the study.
NVESTIGATION of THE RELATIONSHIP BETWEEN MIDWIFERY STUDENTS' INTERCULTURAL SENSITIVITY and COMPASSION LEVEL
Authors: ŞİMŞEK  KÜÇÜKKELEPÇE Didem , ÜLKÜ BULUT ÖZLEM , İNAN KIRMIZIGÜL EBRU , GÖLBAŞI ZEHRA
Published: March 2022

Due to the nature of the midwifery profession, midwives care for individuals in different cultures. This research was conducted to examine the relationship between midwifery students' intercultural sensitivity and their level of compassion. the research is relationship-seeking-descriptive type and was conducted with 206 students studying in midwifery departments in different cities and universities in Turkey. Data in the study were obtained by using the Descriptive Characteristics Form, the Intercultural Sensitivity Scale (ISS), and the Compassion Scale (CS).It was determined that the midwifery students' mean ISS score was 83.92±5.56 and CS score was 104.26±9.68, and there was a moderate, positive and significant relationship between students' intercultural sensitivity and privacy awareness (r=0.627, p<0.01)As a result of the study, it is seen that compassion is a significant predictor of intercultural sensitivity. In a globalizing world where the importance of intercultural sensitivity is understood, it is thought that it is important to develop training strategies to train midwives with high compassion levels.
Covid-19 Vaccines Across the Globe-A Case Study
Authors: Varala Ravi , Sekharan Chandra Bala , Bollikolla Hari Babu
Published: March 2022

A brief study on the status of covid-19 vaccines all over the world is presented for the purpose of better understanding to readers.
Sistem Informasi Pembelian Dan Penjualan Barang Bekas Berbasis Java Desktop Pada Toko Besi Tua Samin
Authors: Londol Marwan M.
Published: March 2022

Proses pendataan pembelian dan penjualan barang bekas di toko besi tua Samin saat ini masih dilakukan secara manual, yaitu setiap transaksi pembelian dan penjualan dicatat dalam sebuah buku transaksi. Pencatatan dan perhitungan dengan cara manual merupakan pekerjaan yang  tidak  efektif  dan  efisian,  Karena  bisa  saja  terjadi  kesalahan pendataan atau perhitungan yang mengakibatkan kerugian Metode penelitian dalam penelitian ini menggunakan pendekatan metode Kualitatif. Sumber data kualitatif diperoleh melalui observasi dan wawancara serta Studi Pustaka yang berhubungan dengan   teori-teori yang menunjang  proses penyusunan Karya Tulis Minor. Hasil yang diperoleh pada penelitian yaitu, sistem dapat mengola data barang, data pembelian dan penjualan serta dapat memproses nota pembelian dan penjualan. Dengan adanya sistem informasi pembelian dan penjualan barang bekas ini di harapkan dapat membantu pihak toko besi Samin dalam mengelola data penjualan dan pembelian.
Sistem Informasi Monitoring Pekerjaan Sales Di PT. Bosowa Berlian Motor Cabang Luwuk Banggai Berbasis Web
Authors: Putra Yasa I Ketut
Published: March 2022

Bosowa Berlian Motor Cabang Luwuk Banggai yang merupakan perusahan dengan label penjualan mobil. Berkembangnya penjualan mobil yang pesat tidak diiringi dengan pembuatan monitoring pekerjaan sales selama ini monitoring pekerjaan sales menggunakan papan tulis yang ditulis setiap satu pekan yang dinilai kurang efektif. Metode penelitian yang digunakan penulis dalam penyusunan karya tulis minor yaitu metode Observasi yaitu Pengumpulan data dengan mengadakan penelitian dan meninjau secara langsung ke lapangan dan metode Studi Pustaka yaitu mengambil referensi dari buku-buku serta sumber-sumber yang dapat dijadikan acuan dalam penulisan penelitian ini. Hasil yang diperoleh pada penelitian yaitu, sistem informasi monitoring pekerjaan sales pada PT. Bosowa Berlian Motor Cabang Luwuk Banggai Selama ini monitoring pekerjaan sales menggunakan papan tulis yang ditulis setiap satu pekan yang dinilai kurang efektif sistem yang ada perlu dikembangkan lagi agar memonitoring pekerja secara up to date. Dengan adanya sistem informasi monitoring pekerjaan sales ini di harapkan dapat membantu proses monitoring Pekerjaan Sales yang lebih efektif dan menarik yang dapat digunakan dengan mudah oleh perusahaan serta dapat memonitoring pekerjaan sales secara up to date.
Preparation and Characterization of Lidocaine-Loaded, Microemulsion-Based Topical Gels
Authors: Daryab Mahshid , Faizi Mehrdad , Mahboubi Arash , Aboofazeli Reza
Published: March 2022

: Microemulsion-based gels (MBGs) were prepared for transdermal delivery of lidocaine and evaluated for their potential for local anesthesia. Lidocaine solubility was measured in various oils, and phase diagrams were constructed to map the concentration range of oil, surfactant, cosurfactant, and water for oil-in-water (o/w) microemulsion (ME) domains, employing the water titration method at different surfactant/cosurfactant weight ratios. Refractive index, electrical conductivity, droplet size, zeta potential, pH, viscosity, and stability of fluid o/w MEs were evaluated. Carbomer® 940 was incorporated into the fluid drug-loaded MEs as a gelling agent. Microemulsion-based gels were characterized for spreadability, pH, viscosity, and in-vitro drug release measurements, and based on the results obtained, the best MBGs were selected and subsequently subjected to ex-vivo rat skin permeation anesthetic effect and irritation studies. Data indicated the formation of nano-sized droplets of MEs ranging from 20 - 52 nm with a polydispersity of less than 0.5. In-vitro release and ex-vivo permeation studies on MBGs showed significantly higher drug release and permeation in comparison to the marketed topical gel. Developed MBG formulations demonstrated greater potential for transdermal delivery of lidocaine and advantage over the commercially available gel product, and therefore, they may be considered as potential vehicles for the topical delivery of lidocaine.
Gaze and the Organization of Participation in Collective Visual Conduct
Authors: Kidwell Mardi , Reynolds Edward
Published: March 2022

In this article, we demonstrate how participants make use of others’ gazing actions to monitor and engage events in their surroundings. Specifically, we focus on a tension between one sort of gazing action that participants freely join in, “noticing”, and another, “watching”, that is subject to constraints related to participant identities toward a collective and their corresponding rights of membership that include toward what and with whom they may gaze. Employing the method of conversation analysis, we provide a fine-grained examination of differences between the two gazing actions that include movements of the head, body, eyes, and feet, and highlight how these differences provide a resource for differentially orienting to the environment and joining in visually based activities with others.
Overcoming Vascular Barriers to Improve the Theranostic Outcomes of Nanomedicines
Authors: Tang Yufu , Yu Zhongzheng , Lu Xiaomei , Fan Quli , Huang Wei
Published: March 2022

Nanotheranostics aims to utilize nanomaterials to prevent, diagnose, and treat diseases to improve the quality of patients’ lives. Blood vessels are responsible to deliver nutrients and oxygen to the whole body, eliminate waste, and provide access for patrolling immune cells for healthy tissues. Meanwhile, they can also nourish disease tissues, spread disease factors or cells into other healthy tissues, and deliver nanotheranostic agents to cover all the regions of a disease tissue. Thus, blood vessels are the first and the most important barrier for highly efficient nanotheranostics. Here, the structure and function of blood vessels are explored and how these characteristics affect nanotheranostics is discussed. Moreover, new mechanisms and related strategies about overcoming vascular obstacles for improved nanotheranostic outcomes are critically summarized, and their merits and demerits of each strategy are analyzed. Moreover, the present challenges to completely exhibit the potential of overcoming vascular barriers to improve the theranostic outcomes of nanomedicines in life science are also discussed. Finally, the future perspective is further discussed.
Integrated Design of a Membrane‐Lytic Peptide‐Based Intravenous Nanotherapeutic Suppresses Triple‐Negative Breast Cancer
Authors: Chen Charles H. , Liu Yu‐Han , Eskandari Arvin , Ghimire Jenisha , Lin Leon Chien‐Wei , Fang Zih‐Syun , Wimley William C. , Ulmschneider Jakob P. , Suntharalingam Kogularamanan , Hu Che‐Ming Jack , Ulmschneider Martin B.
Published: March 2022

Membrane‐lytic peptides offer broad synthetic flexibilities and design potential to the arsenal of anticancer therapeutics, which can be limited by cytotoxicity to noncancerous cells and induction of drug resistance via stress‐induced mutagenesis. Despite continued research efforts on membrane‐perforating peptides for antimicrobial applications, success in anticancer peptide therapeutics remains elusive given the muted distinction between cancerous and normal cell membranes and the challenge of peptide degradation and neutralization upon intravenous delivery. Using triple‐negative breast cancer as a model, the authors report the development of a new class of anticancer peptides. Through function‐conserving mutations, the authors achieved cancer cell selective membrane perforation, with leads exhibiting a 200‐fold selectivity over non‐cancerogenic cells and superior cytotoxicity over doxorubicin against breast cancer tumorspheres. Upon continuous exposure to the anticancer peptides at growth‐arresting concentrations, cancer cells do not exhibit resistance phenotype, frequently observed under chemotherapeutic treatment. The authors further demonstrate efficient encapsulation of the anticancer peptides in 20 nm polymeric nanocarriers, which possess high tolerability and lead to effective tumor growth inhibition in a mouse model of MDA‐MB‐231 triple‐negative breast cancer. This work demonstrates a multidisciplinary approach for enabling translationally relevant membrane‐lytic peptides in oncology, opening up a vast chemical repertoire to the arms race against cancer.
Determination of critical Y‐leaf potassium concentrations in pure‐line and hybrid rice
Authors: Gruener Chandler E. , Drescher Gerson L. , Slaton Nathan A. , Roberts Trenton L. , Gbur Edward E. , Hardke Jarrod T.
Published: March 2022

Potassium (K) deficiency symptoms of rice (Oryza sativa L.) are difficult to visually diagnose during reproductive growth. Critical tissue–K concentrations may change across time and within cultivars. Our goal was to evaluate rice yield response to K fertilization and define continuous critical Y‐leaf–K concentrations (YLKC) for the production of ≥95% relative yield in pure‐line and hybrid rice. Ten Y‐leaves (uppermost leaf with a fully developed collar) were collected weekly during rice reproductive growth from selected fertilizer‐K rates (0–150 kg K ha–1) in 13 trials with variable soil‐test K (32–164 mg kg–1). Trials were seeded either with a pure‐line (8) or hybrid (5) cultivar. Significant yield increases from K fertilization occurred in 38% of the trials. Pure‐line cultivars were responsive to K fertilization and rice without fertilizer‐K produced 66–90% of maximum yield produced by fertilized treatments (8,506–11,153 kg ha–1). Hybrid rice receiving no fertilizer‐K produced 96–99% of maximum yield (9,067–12,572 kg ha–1) regardless of soil‐test K. The YLKC increased with increasing fertilizer‐K rate and declined across time for K‐sufficient rice or remained relatively constant across time for rice marginally sufficient or deficient in K. Rice YLKC above 16.0 g K kg–1 between R1 and R2 maximizes pure‐line cultivars yield production. The critical YLKC declined to about 13.0 g K kg–1 between R2 and R3 but was less accurate for diagnosing K deficiency than samples collected before R2. The YLKC can be used to assess pure‐line cultivars’ K nutritional status between the R1 and R2 stages.
Economic returns from three‐year crop rotations under low precipitation in Pacific Northwest
Authors: Long Dan S. , Barroso Judit , Painter Kathleen M. , Reardon Catherine L. , Williams John D.
Published: March 2022

Some producers in the inland Pacific Northwest (PNW) are interested in diversifying the traditional 2‐yr sequence of winter wheat (Triticum aestivum L.) (WW)–summer fallow (SF) with oilseed crops to capture break crop effects. The objective of this study was to compare production costs and economic returns of 2‐yr sequences with those of intensified 3‐yr sequences at a low‐precipitation (<300 mm) site where the long‐term rotation has been WW‐SF. A 5‐year (2014–2018) cropping sequence study was conducted that included summer fallow with intensive tillage (SF) and reduced tillage (RTF) in 2‐yr rotations with WW; and RTF in 3‐yr rotations with WW, winter canola (WN; Brassica napus L.), or spring carinata (SC; Brassica carinata A. Braun) as a primary crop and spring wheat (SW), spring barley (SB; Hordeum vulgare L.), or SC as a secondary crop. Reduced tillage fallow increased WW yields by 14% compared with SF. Production of WN and SC in WN‐SW‐RTF and SC‐SW‐RTF, expressed by equivalent WW yield, was 42%, and 35% of WW in WW‐RTF vs. 67% needed to compensate for 1/3 less cropping with WW. Production of SC in WW‐SC‐RTF was 21% of WW in WW‐RTF vs. 33% needed to compensate. Mean net returns over total costs were negative with WW‐RTF least unprofitable at −US$162 ha−1 followed by WW‐SB‐RTF at −$167 ha−1, WW‐SF at −$180 ha−1, WW‐SC‐RTF at −$191 ha−1, SC‐SW‐RTF at −$205 ha−1, and WN‐SW‐RTF at −$229 ha−1. Including oilseeds in 3‐yr rotations with WW and fallow apparently may be less profitable than WW in 2‐yr rotations with fallow.
Crystal‐size–dependent external surface diffusion barriers in Pt/ZSM‐5 catalyzed n‐pentane isomerization
Authors: Hu Shen , Chen Jiaxuan , Zhang Qunfeng , Liu Junru , Meng Jinlin , Ye Guanghua , Zhou Xinggui , Yuan Weikang
Published: March 2022

Surface barriers persist in the molecular transport across external crystal surface of zeolites, which brings strong influences on zeolite catalysis. This study probes the role of crystal‐size–dependent surface barriers in zeolite catalysis, with n‐pentane isomerization catalyzed by Pt/ZSM‐5 as a model reaction system. Chemical liquid deposition of SiO2 is performed to reduce surface barriers on ZSM‐5 crystals with different sizes. After SiO2 deposition, surface barriers on both small (266 nm) and large (1304 nm) crystals are significantly reduced, while the improvement in catalytic activity for the large crystals (76.1%–129.1%) is much higher than that for the small ones (−17.4% to 16.7%). For the large ZSM‐5 crystals, diffusion limitation is stronger, and thus the effect of surface barriers on catalytic activity is more important. This study reveals the unique role of crystal‐size–dependent surface barriers in zeolite catalysis, and understanding this is important for the optimal design of zeolite catalysts.
Microsecond Backbone Motions Modulate the Oligomerization of the DNAJB6 Chaperone
Authors: Cawood Emma E. , Clore G. Marius , Karamanos Theodoros K.
Published: March 2022

DNAJB6 is a prime example of an anti‐aggregation chaperone that functions as an oligomer. DNAJB6 oligomers are dynamic and subunit exchange is critical for inhibiting client protein aggregation. The T193A mutation in the C‐terminal domain (CTD) of DNAJB6 reduces both chaperone self‐oligomerization and anti‐aggregation of client proteins, and has recently been linked to Parkinson's disease. Here, we show by NMR, including relaxation‐based methods, that the T193A mutation has minimal effects on the structure of the β‐stranded CTD but increases the population and rate of formation of a partially folded state. The results can be rationalized in terms of β‐strand peptide plane flips that occur on a timescale of ≈100 μs and lead to global changes in the overall pleat/flatness of the CTD, thereby altering its ability to oligomerize. These findings help forge a link between chaperone dynamics, oligomerization and anti‐aggregation activity which may possibly lead to new therapeutic avenues tuned to target specific substrates.
Metal‐free, Phosphoric Acid‐catalyzed Regioselective 1,6‐Hydroarylation of para‐Quinone Methides with Indoles in Water
Authors: Xiong Biquan , Si Lulu , Liu Yu , Xu Weifeng , Jiang Tao , Cao Fan , Tang Ke‐Wen , Wong Wai‐Yeung
Published: March 2022

An efficient, cheap and green protocol for the highly regioselective 1,6‐hydroarylation of para‐quinone methides (p‐QMs) with indoles at the C‐3 position has been established by phosphoric acid catalysis in water under transition‐metal‐free reaction conditions. A wide range of indole derivatives and para‐quinone methides (p‐QMs) are compatible for the reaction, affording the corresponding 1,6‐hydroarylation products with good to excellent yields. The possible mechanism of the reaction has been explored through step‐by‐step control experiments. The protocol is convenient for practical applications, leading to a safe, green and feasible way for the formation of C‐3 diarylmethyl functionalized indole derivatives.
Maternal hereditary hemolytic anemia and birth defects in the National Birth Defects Prevention Study
Authors: Papadopoulos Eleni A. , Fisher Sarah C. , Howley Meredith M. , Browne Marilyn L. ,   National Birth Defects Prevention Study
Published: March 2022

Objectives

Hereditary hemolytic anemia (HHA) results from genetic mutations that cause red blood cell abnormalities. Little research exists on the relationship between HHA and birth defects. Using data from the National Birth Defects Prevention Study (NBDPS), we described characteristics of HHA‐exposed women and estimated associations between HHA during pregnancy and specific birth defects.

Methods

The NBDPS was a population‐based, case–control study of major birth defects and included pregnancies with estimated delivery dates from October 1997 through December 2011. Participants were ascertained from hospital discharge lists or birth defect registries at 10 sites. Trained interviewers collected information about pregnancy exposures via telephone questionnaire. We described characteristics among HHA‐exposed women and calculated crude odds ratios and exact 95% confidence intervals for defects with ≥3 exposed cases.

Results

Among 31 HHA‐exposed women (28 cases/3 controls), 13 (42%) reported sickle cell anemia, 17 (55%) reported thalassemia, and one (3%) reported hereditary spherocytosis. The average age at delivery for HHA‐exposed case women was 27.3 years (range: 17–38). The majority (82%) of HHA‐exposed case women reported additional conditions during pregnancy, including hypertension, genitourinary infections, and respiratory illnesses. Additionally, 93% of case women reported using medication during pregnancy. Among the 28 cases, 18 (64%) had isolated birth defects. The defects with ≥3 exposed cases were anencephaly, atrial septal defect, gastroschisis, and cleft palate. Except for anencephaly, the 95% confidence intervals for all estimates were close to or included the null.

Conclusion

This hypothesis‐generating study adds to the sparse literature on the association between HHA and birth defects.
A novel signature based on immune‐related gene pairs and clinical features to predict prognosis and treatment effect in “driver gene negative” lung adenocarcinoma
Authors: Cai He‐yuan , Yang Hao‐shuai , Shan Shi‐chao , Lei Yi‐yan , Zou Jian‐yong , Zhu Ying , Luo Hong‐he
Published: March 2022

Objective

Examining the role of immune‐related genes (IRGs) in “driver gene negative” lung adenocarcinoma (LUAD) may provide new ideas for the treatment and study for this LUAD subgroup. We aimed to find the hub immune‐related gene pairs can stratify the risk of “driver‐gene‐negative” LUAD.

Materials and Methods

IRGs were identified according to ImmPort database based on RNA sequencing results of tumors and normal tissues from 46 patients with “driver gene negative” LUAD at The First Affiliated Hospital of Sun Yat‐sen University and cyclically singly paired as immune‐related gene pairs (IRGPs). Multivariate Cox analysis was used to construct an immune risk model and a prognostic nomogram combining was also been developed. Immune microenvironment landscape described by CIBERSORT and drug sensitivity calculated by pRRophetic algorithm were used to explore possible treatment improvements.

Results

A novel immune risk model with 5‐IRGPs (CD1A|CXCL135, CD1A|S100A7L2, IFNA7|CMTM2, IFNA7|CSF3, CAMP|TFR2) can accurately distinguish patients in the high‐ and low‐risk groups. Risk score act as an independent prognostic factor and is related to clinical stage. There are significant differences in tumor immune microenvironment and PD‐1/PD‐L1/CTLA‐4 expression between groups. The low‐risk patient may benefit more from the commonly used chemotherapy regimens such as gemcitabine and paclitaxel.

Conclusion

This study constructed 5‐IRGPs as a reliable prognostic tool and may represent genes pairs that are potential rationale for choice of treatment for “driver gene negative” LUAD.
Therapist attitudes and countertransference as predictors of professional quality of life and burnout among psychotherapists
Authors: Houshangi Homa , Khanipour Hamid , Farahani Mohammad Naghy
Published: March 2022

This study aimed to examine the role of attitudes towards psychotherapy and countertransference dimensions as predictors of professional quality of life and burnout among psychotherapists in Iran. Participants were 259 psychotherapists who worked in mental health centres in Tehran (Iran), and they completed the Professional Quality of Life questionnaire, the Therapist Response Questionnaire and the Therapist Attitudes Scale. Professional quality of life was associated with countertransference dimensions and attitude towards psychotherapy. This study concludes that psychotherapists can benefit from working on their specific countertransference issues and re‐evaluating their basic attitudes towards psychotherapy to achieve the highest levels of professional satisfaction. Culture may play a role in a specific therapist's attitude and difficulties in addressing certain aspects of countertransference.
A Phase 1, Open‐Label Study to Evaluate the Effect of Food and Concomitant Itraconazole Administration on the Pharmacokinetics of AMG 986 in Healthy Subjects
Authors: Trivedi Ashit , Mather Omar , Vega Silvia , Hutton Shauna , Hellawell Jennifer , Lee Edward
Published: March 2022

This phase 1, open‐label study evaluated the effect of food and administration of the cytochrome P450 3A4 and P‐glycoprotein inhibitor itraconazole (ITZ) on the pharmacokinetics of AMG 986. In cohort 1, 12 healthy subjects received a single oral dose of AMG 986 200 mg ± food on days 1 and 10. In cohort 2, 15 healthy subjects received oral ITZ 200 mg once daily on days 8 to 15 and a single oral dose of AMG 986 10 mg on days 1 and 11. The geometric least squares mean ratios of fed/fasted for AMG 986 maximum observed concentration (Cmax) and area under the plasma concentration–time curve from time 0 to infinity (AUCinf) were 0.76 (90%CI, 0.61‐0.95) and 1.07 (90%CI, 0.94‐1.22), respectively. The geometric least squares mean ratios of AMG 986 10 mg plus ITZ 200 mg/AMG 986 10 mg alone for AMG 986 Cmax and AUCinf were 1.36 (90%CI, 1.25‐1.48) and 5.13 (90%CI, 4.71‐5.59), respectively. Overall, 3 subjects experienced mild treatment‐related adverse events; there were no serious or fatal adverse events. In conclusion, food had no apparent effect on the exposure of AMG 986 200 mg; therefore, food restrictions are not required. Potent cytochrome P450 3A4 and/or P‐glycoprotein inhibitors may warrant AMG 986 dose reduction and should be coadministered with caution in patients with heart failure treated with AMG 986.
Reconsidering the formation of dust void in axial magnetic field
Authors: Wang Yunfan , Sun Pingyuan , Yu Yongjun , Chen Zhaoyang , Huang Feng
Published: March 2022

We propose a nonlinear fluid model to describe the dust void formation in a magnetic field environment. It is found that the radius of the dust void keeps decreasing as the intensity of the magnetic field increases. Further research shows that the circular motion of ions affects the balance of electric field force and ion‐drag force, which is the main reason for the change of dust voids. The Lorentz force of grains theoretically tends to increase the radius of the dust void, but the force is so small that it can be ignored.
The number of circulating CD26 expressing cells is decreased in critical COVID‐19 illness
Authors: deKay Joanne T. , May Teresa L. , Riker Richard R. , Rud Jonathan , Gagnon David J. , Sawyer Douglas B. , Seder David B. , Ryzhov Sergey
Published: March 2022

We evaluated the number of CD26 expressing cells in peripheral blood of patients with COVID‐19 within 72 h of admission and on day 4 and day 7 after enrollment. The majority of CD26 expressing cells were presented by CD3+CD4+ lymphocytes. A low number of CD26 expressing cells were found to be associated with critical‐severity COVID‐19 disease. Conversely, increasing numbers of CD26 expressing T cells over the first week of standard treatment was associated with good outcomes. Clinically, the number of circulating CD26 cells might be a marker of recovery or the therapeutic efficacy of anti‐COVID‐19 treatment. New therapies aimed at preserving and increasing the level of CD26 expressing T cells may prove useful in the treatment of COVID‐19 disease.
GAs with escape from stagnation of search for multiset iteration permutations problem – consecutive meals planning
Authors: Kashima Tomoko , Orito Yukiko , Someya Hiroshi
Published: March 2022

In this paper, consecutive meals planning is formulated as a multiset iteration permutation problem that determines the optimal meals plan on a period consisting of consecutive days. In this problem, a meal is characterized by some characteristics such as food style, ingredient, cooking method, and so on. The evaluation function is defined by use of information entropy for measuring the appearance order of meal's characteristics on the meals plan. For optimizing this problem, Genetic Algorithms (GAs) with escape from stagnation of search are proposed. It is empirically shown that the proposed GAs with escape operation work better than the conventional permutation GA without escape operation for small and large size optimization problems.
A proposal of eye glance input interface using smartphone built‐in camera
Authors: Saiga Yu , Mizuno Tota , Matsumoto Yu , Mito Kazuyuki , Itakura Naoaki
Published: March 2022

The purpose of this study is to develop a line‐of‐sight input interface using the eye‐glance input method, which uses a glance eye movement and method of estimating the eye‐control movement by analyzing the image of the area near the eye‐ball. The motion was discriminated by taking an image using the built‐in camera of a smartphone to rapidly look at the four corners of the smartphone and calculate the moving distance of the eyeball, which was divided into horizontal and vertical components using the optical flow function in Open CV library. In the experiment, we obtained data by asking the subjects to look at the reciprocate of quick gaze movements at each of the four corners and the center of the screen. As a result of data analysis, characteristics of waveforms were obtained for the movements looking at the four corners, and we could determine which of the four corners the users were looking at. Furthermore, by distinguishing between camera shake and line‐of‐sight movement using the variance value, the discrimination rate was 90% or more even when held in the hand. It was shown that the Eye Glance movement can be measured with a smartphone as well as a PC.
Influence of the Intraday Electricity Market Structure on the Degradation of Li‐Ion Batteries Used to Firm Photovoltaic Production
Authors: Beltran Hector , Ayuso Pablo , Cardo-Miota Javier , Segarra-Tamarit Jorge , Aparicio Néstor , Pérez Emilio
Published: March 2022

This article considers the introduction of Li‐ion batteries in photovoltaic power plants to firm their energy production and analyzes the dependence of their degradation on the structure of the electricity market where the power production is traded. The operation of the batteries is decided as a result of successive optimization problems that benefit from the use of deep‐learning‐based irradiance forecasting tools with low prediction error, which allows the batteries to keep a small size. In addition, state‐of‐the‐art battery aging models are handled to derive a realistic lifetime prognosis. The simulation results obtained by using real data from three European locations, which have different irradiance patterns and market structures, show how the proposed control strategy makes it possible to decouple the saturation rate of the batteries from the climatic conditions of the plant location. Furthermore, regarding the market structure, the results show that the shorter the energy block and the closer the lead time, the lower is the degradation of the batteries.
Ionic Thermoelectric Effect Inducing Cation‐Enriched Surface of Hydrogel to Enhance Output Performance of Triboelectric Nanogenerator
Authors: Chen Yizhong , Shi Chaosheng , Zhang Jingfei , Dai Yongqiang , Su Yu , Liao Bing , Zhang Mingqiu , Tao Xiaoming , Zeng Wei
Published: March 2022

The most robust consensus related to ionic‐hydrogel‐based triboelectric nanogenerator (TENG) is that the charge density at the solid interface plays a pivotal role in its output performance. However, there has been no reliable evidence of the mechanism regarding the influence of ion enrichment on TENG. Higher surface charge density at the solid interface could result in higher output performance. Herein, the ionic hydrogel is prepared through polymerization reaction of the organic monomers with LiCl as the ionic conductor. The ion migration on the hydrogel surface is regulated via tuning the temperature difference between the top and bottom sides. Upon contacting with the upper electrode, more induction charges are induced on the cation‐enriched surface of hydrogel, leading to a larger output of the TENG. At the temperature difference of 25 °C, the open‐circuit voltage and maximum output power density is increased by 77% and 166% compared with the TENG without temperature field, respectively. When the temperature of the hydrogel surface is higher than 50 °C, the output performance of TENG would decrease due to the water loss of hydrogel. This research will advance further understanding of the mechanism of thermoelectric ionic conductors in TENGs, self‐powered sensors, and wearable devices.
Fire test of metal sandwich plates during a window spill fire
Authors: Zhou Ru , Yu Zhenjiang , Chen Zhihao , Qian Jianan , Jiang Juncheng
Published: March 2022

To study the melting characteristics and fire spreading behavior of metal sandwich plates during the fire spill plume, a small experimental platform was built according to NFPA285 and ISO 13785‐2 test standards. The results showed that the fire behavior is driven by the exposure of the core material, and this happens by routing of the panels, deformation due to heat exposure or melting of the core. The fire risk of the façade of the metal sandwich plate with different splicing models was evaluated. It was found that when there was no splicing gap in the midline of the fire source during a window spill fire, the peak temperature above the window was the lowest. In the façade system, the width of the metal sandwich plate and the maximum temperature showed an inverse linear relationship. When the height of the plate decreased, the heating rate of the plate above the window increased. The fire spread in the façade system was accompanied by a change in the sandwich panel size, and the corresponding dimensionless expression was obtained.
Comprehensive evaluation of Luzhou‐flavor liquor quality based on fuzzy mathematics and principal component analysis
Authors: Liu Yanbo , Qiao Zhangning , Zhao Zhijun , Wang Xian , Sun Xiyu , Han Suna , Pan Chunmei
Published: March 2022

Currently, the primary method of identifying high‐ and low‐quality liquors is sensory tasting, which is prone to uncertainty caused by the biases of tasters. To address this problem, this study used color, aroma, taste, and style as four factors affecting the sensory quality of Luzhou‐flavor liquor; determined the weights of each factor; and quantitatively evaluated the sensory quality of five different Luzhou flavor liquor using fuzzy mathematical methods. The volatile aromatic substances in the liquor samples were detected by GC‐MS, and analyzed using principal component analysis. The results obtained from fuzzy mathematics and principal component analysis indicated that the comprehensive evaluation system was scientifically sound and reasonably constructed.