bluuebunny/crossref_metadata_2025 huggingface dataset:
Risk prediction models for diabetic nephropathy among type 2 diabetes patients in China: a systematic review and meta-analysis
Authors: Xu Wenbin , Zhou Yanfei , Jiang Qian , Fang Yiqian , Yang Qian
Published: July 2024

Objective

This study systematically reviews and meta-analyzes existing risk prediction models for diabetic kidney disease (DKD) among patients with type 2 diabetes, aiming to provide references for scholars in China to develop higher-quality risk prediction models.

Methods

We searched databases including China National Knowledge Infrastructure (CNKI), Wanfang Data, VIP Chinese Science and Technology Journal Database, Chinese Biomedical Literature Database (CBM), PubMed, Web of Science, Embase, and the Cochrane Library for studies on the construction of DKD risk prediction models among type 2 diabetes patients, up until 28 December 2023. Two researchers independently screened the literature and extracted and evaluated information according to a data extraction form and bias risk assessment tool for prediction model studies. The area under the curve (AUC) values of the models were meta-analyzed using STATA 14.0 software.

Results

A total of 32 studies were included, with 31 performing internal validation and 22 reporting calibration. The incidence rate of DKD among patients with type 2 diabetes ranged from 6.0% to 62.3%. The AUC ranged from 0.713 to 0.949, indicating the prediction models have fair to excellent prediction accuracy. The overall applicability of the included studies was good; however, there was a high overall risk of bias, mainly due to the retrospective nature of most studies, unreasonable sample sizes, and studies conducted in a single center. Meta-analysis of the models yielded a combined AUC of 0.810 (95% CI: 0.780–0.840), indicating good predictive performance.

Conclusion

Research on DKD risk prediction models for patients with type 2 diabetes in China is still in its initial stages, with a high overall risk of bias and a lack of clinical application. Future efforts could focus on constructing high-performance, easy-to-use prediction models based on interpretable machine learning methods and applying them in clinical settings.

Registration

This systematic review and meta-analysis was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement, a recognized guideline for such research.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42024498015.
Multi-objective optimization strategy for the distribution network with distributed photovoltaic and energy storage
Authors: Qi Huanruo , Yan Xiangyang , Kang Yilong , Yang Zishuai , Ma Siyuan , Mi Yang
Published: July 2024

The randomness and fluctuation of large-scale distributed photovoltaic (PV) power will affect the stable operation of the distribution network. The energy storage system (ESS) can effectively suppress the power output fluctuation of the PV system and reduce the PV curtailment rate through charging/discharging states. In order to improve the operation capability of the distribution network and PV consumption rate, an optimal multi-objective strategy is proposed based on PV power prediction. First, the back propagation (BP) neural network with an improved genetic algorithm (GA) is used to predict PV power output. Furthermore, an adaptive variability function is added to the GA to improve the prediction accuracy. Then, the distribution network model containing distributed PV and the ESS is constructed. The optimal object contains network power loss, voltage deviation, and PV consumption. The model is solved based on the improved multi-objective particle swarm optimization (MOPSO) algorithm of Pareto optimality. The probabilistic amplitude is adopted to encode the particles for avoiding local optimal. Finally, the proposed optimal strategy is verified by the IEEE 33-bus distribution network. The results show that the proposed strategy has an obvious effect on reducing the network power loss and voltage deviation, as well as improving the PV consumption rate.
Mapping scholarly publications of energy conservation and emission reduction in support of the sustainable development goals (SDGs)
Authors: Xu Kewei , Yang Mingmei , Yang Jiamiao , Nataliia Butina , Cai Yuanyuan , Zhang Hao , Wang Yanwen
Published: July 2024

In light of continuous advancements in science and technology, the global economy is experiencing rapid growth. However, this growth has been accompanied by significant depletion of natural resources and environmental degradation. Consequently, there is a burgeoning global emphasis on energy conservation, emissions reduction, and sustainable development. In this study, based on the Science Citation Index Expanded (SCIE) and Social Science Citation Index (SSCI) databases from 1990 to 2022, a statistical analysis of energy conservation and emission reduction in alignment with Sustainable Development Goals (SDGs)-related publications was undertaken using biblimometric methods. The findings reveal that (1) In recent years, there has been a discernible increase in global research on this subject, especially since 2009, with a sustained trend of exceeding 100 publications per annum. China prominently contributing to this domain, the proportion reached 34.2%, reflecting a growing emphasis on eco-friendly development trends. (2) Due to the burgeoning significance of energy conservation and emission reduction, there has been a notable escalation in research efforts pertaining to “Energy and Fuels,” “Environmental Science” and “Green and Sustainable Science and Technology” and other related subjects. (3) Regarding the keyword analysis, “renewable energy” as the most frequently encountered term, often paired with “CO2 emissions.” This association underscores the pivotal role of renewable energy technologies in advancing green development initiatives and mitigating emissions. (4) China, United States and United Kingdom occupy central positions in terms of both paper publication volume and collaborative networks, collectively accounting for about 54.7%, and these countries are pivotal contributors to the scholarly discourse on sustainable development and environmental conservation. (5) From 1990 to 2022, the top 20 cited articles predominantly address diverse sub-goals of Sustainable Development Goal 7, with a common emphasis on enhancing energy efficiency, sustainability and renewable energy. These findings furnish valuable analytical insights for subsequent researchers investigating energy conservation and emission reduction as well as sustainable development endeavors.
Development of a live attenuated vaccine candidate for equid alphaherpesvirus 1 control: a step towards efficient protection
Authors: Hu Yue , Wu Guiling , Jia Qinrui , Zhang Baozhong , Sun Wencheng , Sa Ruixue , Zhang Siyu , Cai Weifan , Jarhen  , Ran Duoliang , Liu Jianhua
Published: July 2024

Equid alphaherpesvirus 1 (EqAHV1) is a viral pathogen known to cause respiratory disease, neurologic syndromes, and abortion storms in horses. Currently, there are no vaccines that provide complete protection against EqAHV1. Marker vaccines and the differentiation of infected and vaccinated animals (DIVA) strategy are effective for preventing and controlling outbreaks but have not been used for the prevention of EqAHV1 infection. Glycoprotein 2 (gp2), located on the envelope of viruses (EqAHV1), exhibits high antigenicity and functions as a molecular marker for DIVA. In this study, a series of EqAHV1 mutants with deletion of gp2 along with other virulence genes (TK, UL24/TK, gI/gE) were engineered. The mutant viruses were studied in vitro and then in an in vivo experiment using Golden Syrian hamsters to assess the extent of viral attenuation and the immune response elicited by the mutant viruses in comparison to the wild-type (WT) virus. Compared with the WT strain, the YM2019 Δgp2, ΔTK/gp2, and ΔUL24/TK/gp2 strains exhibited reduced growth in RK-13 cells, while the ΔgI/gE/gp2 strain exhibited significantly impaired proliferation. The YM2019 Δgp2 strain induced clinical signs and mortality in hamsters. In contrast, the YM2019 ΔTK/gp2 and ΔUL24/TK/gp2 variants displayed diminished pathogenicity, causing no observable clinical signs or fatalities. Immunization with nasal vaccines containing YM2019 ΔTK/gp2 and ΔUL24/TK/gp2 elicited a robust immune response in hamsters. In particular, compared with the vaccine containing the ΔTK/gp2 strain, the vaccine containing the ΔUL24/TK/gp2 strain demonstrated enhanced immune protection upon challenge with the WT virus. Furthermore, an ELISA for gp2 was established and refined to accurately differentiate between infected and vaccinated animals. These results confirm that the ΔUL24/TK/gp2 strain is a safe and effective live attenuated vaccine candidate for controlling EqAHV1 infection.
Case report: Potential role of immunotherapy in thymic malignancies: a unique case of a durable and complete response upon an immune checkpoint inhibitor
Authors: Luciano Angelo , Pietroluongo Erica , Ottaviano Margaret , Grieco Angela , Peddio Annarita , De Placido Pietro , Servetto Alberto , Mascolo Massimo , Varricchio Silvia , Bianco Roberto , Palmieri Giovannella , Giuliano Mario
Published: July 2024

Thymic epithelial tumors are rare malignancies with an incidence of 1.7 cases per million people per year. They pose significant management challenges due to their association with autoimmune disorders. In this case report, we present the 21-year history of a patient diagnosed with advanced B2/B3 thymoma and Good’s syndrome. The patient achieved a complete and durable response after receiving only two cycles of the immune checkpoint inhibitor Nivolumab. However, this positive outcome was accompanied by the development of severe immune-related myocarditis complicated by reactivation of cytomegalovirus. Moreover, the patient developed a highly uncommon subdiaphragmatic pararectal dissemination of the thymic tumor, which is a condition rarely described in the literature. Despite the success in achieving complete and durable response with immune checkpoint inhibitors, the emergence of immune-related adverse events highlights the potential challenges associated with these treatments, emphasizing the need for careful monitoring and a comprehensive understanding of the intricate interplay between cancer, immune system dysregulations and immunotherapy.
Exploring the role of innate lymphoid cells in the periodontium: insights into immunological dynamics during orthodontic tooth movement
Authors: Pastille Eva , Konermann Anna
Published: July 2024

Background

The periodontal ligament (PDL) experiences considerable mechanical stresses between teeth and bone, vital for tissue adaptation, especially in orthodontic tooth movement (OTM). While recent research emphasizes the role of innate lymphoid cells (ILCs) in regulating sterile inflammation, their involvement in periodontal tissues during OTM remains largely unexplored.

Methods

In this study, PDL tissues from orthodontic patients (n = 8) were examined using flow cytometry to detect ILC subtypes. Transwell co-culture systems were used to expose PDL cells to mechanical strain, followed by measuring migration and ratios of sorted ILC subtypes. Statistical analyses were conducted using paired Student’s t-test, Kruskal-Wallis test, Dunn’s post-test and one-way/two-way ANOVA with Tukey’s post-test (p≤ 0.05; **, p≤ 0.01; ***, p≤ 0.001).

Results

Our findings demonstrate a significant increase in CD127+ CD161+ ILC frequencies in PDL tissues during OTM, indicating ILC involvement in sterile inflammation induced by orthodontic forces. Co-culture assays show directed migration of ILC subsets towards PDL cells and substantial proliferation and expansion of ILCs.

Conclusions

This study is the first to comprehensively investigate the role of ILCs in sterile inflammation during OTM, revealing their presence and distribution within PDL tissues’ innate immune response in vivo, and exploring their migratory and proliferative behavior in vitro. The results suggest a crosstalk between ILCs and PDL cells, potentially influencing the inflammatory response and tissue remodeling processes associated with OTM.
The current status and trends of oral bone regeneration materials: a bibliometric analysis from 1991 to 2023
Authors: Tu Ronglin , Liu Xiaoming , Xu Lin , Yao Xuemin , Zhang Ran , Li Jiadi , Zhang Wenjun , Liu Jinrong , Wu Xiuping , Li Bing
Published: July 2024

Objectives: Due to the complexity and importance of oral bone structure, oral bone regeneration materials differ from those used in other parts of the body. To study the research trends and hotspots of oral bone regeneration materials, this paper conducts a bibliometric analysis of related papers from 1991 to 2023 (retrieved on 27 September 2023).

Materials and methods: Using bibliometric methods, two visualization metric software, Citespace and VOSviewer, were used to analyze 1217 papers in SCIE, including paper analysis, author analysis, country and institution analysis, keyword analysis, and cited literature analysis.

Results: ① The number of papers is generally increasing and gradually stabilizing; ② Buser D is the most influential author, while Jung, Ronald E has the highest number of papers and total citations; ③ The United States has the highest number of papers and citation frequency. The University of Bern and the University of Zurich in Switzerland are not only the institutions with the most papers, but also the institutions with the most collaborations with other institutions. ④ Many research directions have persisted for decades since their inception. The field of oral bone; regeneration materials is constantly developing and improving. In recent years, the research direction in this field may mainly focus on the role of blood cells and proteins in bone regeneration. ⑤ In recent years, the types of cited literature mainly include barrier membranes, alveolar ridge augmentation, bone graft materials, histological examination, and in vivo animal experimental models.

Conclusion: The United States and Switzerland have a significant influence in the field of oral bone regeneration materials. The research hotspot in recent years is mainly on tissue engineering materials. However, traditional materials still occupy a large proportion in clinical treatment or research. In addition, the combined use of new and old materials has gradually become one of the research hotspots in this field.
One hundred years of Ecuadorian biomedical scientific output and its association with the main causes of mortality: a bibliometric study
Authors: Sisa Ivan , Caicedo-Potosí Jhon , Cordovez María , Verdezoto Clara , Barreno Mishell , Coral Martín , Herrera-Franco Gricelda
Published: July 2024

Introduction

Historically, low-and middle-income countries have been scarce producers of biomedical research; only 2% of the global scientific output is produced by these countries despite accounting for 92% of the global burden of disease. In addition, few low-and middle-income countries have exhaustively mapped and analyzed their scientific production in health and its association with main local burden of disease.

Objective

To evaluate the evolution of biomedical research in Ecuador over the last 100 years and its relationship with the main causes of mortality.

Methods

A bibliometric study embedded in a systematic review design was carried out using biomedical publications indexed in Scopus and Web of Science (WoS) during the period 1920–2021. Information from the National Institute of Statistics and Census was used to identify the main causes of mortality.

Results

Our search strategy identified 16,697 publications related to biomedicine in Ecuador. Of these 3,225 articles met the criteria for this study. Since 2010, there has been an exponential increase in scientific production in biomedicine. This increase was predominantly based on cross-sectional observational studies (49.67%). During the period analyzed (1920–2021), biomedical production was distributed with 52.43% in clinical research, 37.79% in public health, and 9.77% in basic sciences. The research focus with the highest number of publications was epidemiology and surveillance system of diseases (23.44%). Additionally, private universities are the largest producers of biomedical research compared to public universities, 40.12% vs. 19.60%, respectively. Of the total biomedical research produced, 18.54% is associated with the main causes of mortality, and the Ecuadorian private university is the largest contributor to these studies compared to public universities, 39.97% vs. 16.72%.

Conclusion

In one century, Ecuador produced 3,225 articles in biomedicine, according to our criteria. 18.54% of the total produced is aimed at solving the main causes of mortality in the country. Private universities are the leaders in scientific production related to health in Ecuador.
Manganese reduction and associated microbial communities in Antarctic surface sediments
Authors: Wunder Lea C. , Breuer Inga , Willis-Poratti Graciana , Aromokeye David A. , Henkel Susann , Richter-Heitmann Tim , Yin Xiuran , Friedrich Michael W.
Published: July 2024

The polar regions are the fastest warming places on earth. Accelerated glacial melting causes increased supply of nutrients such as metal oxides (i.e., iron and manganese oxides) into the surrounding environment, such as the marine sediments of Potter Cove, King George Island/Isla 25 de Mayo (West Antarctic Peninsula). Microbial manganese oxide reduction and the associated microbial communities are poorly understood in Antarctic sediments. Here, we investigated this process by geochemical measurements of in situ sediment pore water and by slurry incubation experiments which were accompanied by 16S rRNA sequencing. Members of the genus Desulfuromusa were the main responder to manganese oxide and acetate amendment in the incubations. Other organisms identified in relation to manganese and/or acetate utilization included Desulfuromonas, Sva1033 (family of Desulfuromonadales) and unclassified Arcobacteraceae. Our data show that distinct members of Desulfuromonadales are most active in organotrophic manganese reduction, thus providing strong evidence of their relevance in manganese reduction in permanently cold Antarctic sediments.
Inhibitory effect of Lonicera japonica flos on Streptococcus mutans biofilm and mechanism exploration through metabolomic and transcriptomic analyses
Authors: Wang Lin , Liu Ping , Wu Yulun , Pei Hairun , Cao Xueli
Published: July 2024

Introduction

Streptococcus mutans was the primary pathogenic organism responsible for dental caries. Lonicera japonica flos (LJF) is a traditional herb in Asia and Europe and consumed as a tea beverage for thousands of years.

Methods

The inhibitory effect and mechanism of LJF on biofilm formation by S. mutans was investigated. The active extracts of LJF were validated for their inhibitory activity by examining changes in surface properties such as adherence, hydrophobicity, auto-aggregation abilities, and exopolysaccharides (EPS) production, including water-soluble glucan and water-insoluble glucan.

Results and discussion

LJF primarily inhibited biofilm formation through the reduction of EPS production, resulting in alterations in cell surface characteristics and growth retardation in biofilm formation cycles. Integrated transcriptomic and untargeted metabolomics analyses revealed that EPS production was modulated through two-component systems (TCS), quorum sensing (QS), and phosphotransferase system (PTS) pathways under LJF stress conditions. The sensing histidine kinase VicK was identified as an important target protein, as LJF caused its dysregulated expression and blocked the sensing of autoinducer II (AI-2). This led to the inhibition of response regulator transcriptional factors, down-regulated glycosyltransferase (Gtf) activity, and decreased production of water-insoluble glucans (WIG) and water-soluble glucans (WSG). This is the first exploration of the inhibitory effect and mechanism of LJF on S. mutans, providing a theoretical basis for the application of LJF in functional food, oral health care, and related areas.
Time trends in Alzheimer’s disease mortality attributable to metabolic risks and smoking in China from 1990 to 2019: an age-period-cohort analysis
Authors: Sun Simeng , Zhang Ting , Yu Hao , Xia Ting , Yao Yunan , Sun Mengting , Liang Hongmei , Huang Qiaoyu , Wang Weiwei , Yang Huafeng , Hong Xin
Published: July 2024

Background

With the increase in the aging population worldwide, Alzheimer’s disease has become a rapidly increasing public health concern. In the Global Burden of Disease Study 2019, there are three risk factors judged to have evidence for a causal link to Alzheimer’s disease and other dementias: smoking, high body-mass index (HBMI), and high fasting plasma glucose (HFPG).

Objective

This study aimed to analyze trends in AD mortality and the relevant burden across China from 1990 to 2019, as well as their correlation with age, period, and birth cohort.

Methods

The data were extracted from the GBD 2019. Trends in AD mortality attributable to metabolic risks (HFPG and HBMI) and smoking were analyzed using Joinpoint regression. The age-period-cohort (APC) model was used to evaluate cohort and period effects.

Results

From 1990 to 2019, the overall age-standardized mortality rate of AD increased, especially in women. There was an increase in AD mortality due to smoking in the net drift, and it was more significant in women (0.46, 95%CI = [0.09, 0.82]) than men (−0.03, 95%CI = [−0.11, 0.05]). For the cause of HFPG, the net drift values for men and women were 0.82% and 0.43%. For HBMI, the values were 3.14% and 2.76%, respectively, reflecting substantial increases in AD mortality.

Conclusion

Time trends in AD mortality caused by metabolic risks and smoking in China from 1990 to 2019 have consistently increased. Therefore, it is necessary to prevent excessive weight gain and obesity during the later stages of life, especially for females.
Triglyceride glucose-related indexes and lipid accumulation products—reliable markers of insulin resistance in the Chinese population
Authors: Liu Lei , Luo Yufang , Liu Min , Tang Chenyi , Liu Hong , Feng Guo , Wang Meng , Wu Jinru , Zhang Wei
Published: July 2024

Background

Insulin resistance (IR) is a pivotal pathogenic component of metabolic diseases. It is crucial to identify convenient and reliable indicators of insulin resistance for its early detection. This study aimed at assessing the predictive ability of seven novel obesity and lipid-related indices.

Methods

A total of 5,847 female and 3,532 male healthy subjects were included in the study. The triglyceride glucose (TyG) index, TyG-body mass index (TyG-BMI), TyG-waist circumference (TyG-WC), lipid accumulation products (LAP), body roundness index (BRI), body adiposity index (BAI), and visceral adiposity index (VAI) were measured and calculated using the established formulae. IR was diagnosed using the homeostatic model assessment of insulin resistance (HOMA-IR) index over the third quantile.

Results

The levels of all seven lipid-related indices were significantly higher in subjects with higher HOMA-IR values than in those with lower HOMA-IR values. These indices displayed moderate to high effectiveness [receiver operating characteristic (ROC) curve-area under the curve (AUC) > 0.6] in predicting IR. Among them, TyG-BMI (AUC: 0.729), LAP (AUC: 0.708), and TyG-WC (AUC: 0.698) showed the strongest association with HOMA-IR. In the female population, the AUC for TyG-BMI, LAP, and TyG-WC in predicting IR was 0.732, 0.705, and 0.718, respectively. Logistic regression analysis showed the optimal cut-off values of those indicators in predicting IR as follows: TyG-BMI: male subjects – 115.16 [odds ratio (OR) = 6.05, 95% CI: 5.09–7.19], female subjects – 101.58 (OR = 4.55, 95% CI: 4.00–5.16); LAP: male subjects – 25.99 (OR = 4.53, 95% CI: 3.82–5.38), female subjects – 16.11 (OR = 3.65, 95% CI: 3.22–4.14); and TyG-WC: male subjects – 409.43 (OR = 5.23, 95% CI: 4.48–6.24), female subjects – 342.48 (OR = 4.07, 95% CI: 3.59–4.61).

Conclusion

TyG-index-related parameters and LAP appear to be effective predictors of IR in the Chinese population. Specifically, TyG-BMI may be the most appropriate predictor of IR.
Toward a science-based classification of processed foods to support meaningful research and effective health policies
Authors: Trumbo Paula R. , Bleiweiss-Sande Rachel , Campbell Jessica K. , Decker Eric , Drewnowski Adam , Erdman John W. , Ferruzzi Mario G. , Forde Ciaran G. , Gibney Michael J. , Hess Julie M. , Klurfeld David M. , Latulippe Marie E. , O’Connor Lauren E. , Reimers Kristin J. , Rolls Barbara J. , Schulz Jackie , Weaver Connie , Yu Lynn
Published: July 2024

Processed foods have been part of the American diet for decades, with key roles in providing a safe, available, affordable, and nutritious food supply. The USDA Food Guides beginning in 1916 and the US Dietary Guidelines for Americans (DGA) since 1980 have included various types of commonly consumed processed foods (e.g., heated, fermented, dried) as part of their recommendations. However, there are multiple classification systems based on “level” of food processing, and additional evidence is needed to establish the specific properties of foods classified as “highly” or “ultra”-processed (HPF/UPFs). Importantly, many foods are captured under HPF/UPF definitions, ranging from ready-to-eat fortified whole grain breakfast cereals to sugar-sweetened beverages and baked goods. The consequences of implementing dietary guidance to limit all intake of foods currently classified as HPF/UPF may require additional scrutiny to evaluate the impact on consumers’ ability to meet daily nutrient recommendations and to access affordable food, and ultimately, on health outcomes. Based on a meeting held by the Institute for the Advancement of Food and Nutrition Sciences in May 2023, this paper provides perspectives on the broad array of foods classified as HPF/UPFs based on processing and formulation, including contributions to nutrient intake and dietary patterns, food acceptability, and cost. Characteristics of foods classified as UPF/HPFs are considered, including the roles and safety approval of food additives and the effect of food processing on the food matrix. Finally, this paper identifies information gaps and research needs to better understand how the processing of food affects nutrition and health outcomes.
Effects of short-term dietary nitrate supplementation on exercise and coronary blood flow responses in patients with peripheral artery disease
Authors: Kim Danielle Jin-Kwang , Gao Zhaohui , Luck Jonathan C. , Brandt Kristen , Miller Amanda J. , Kim-Shapiro Daniel , Basu Swati , Leuenberger Urs , Gardner Andrew W. , Muller Matthew D. , Proctor David N.
Published: July 2024

Background

Peripheral arterial disease (PAD) is a prevalent vascular disorder characterized by atherosclerotic occlusion of peripheral arteries, resulting in reduced blood flow to the lower extremities and poor walking ability. Older patients with PAD are also at a markedly increased risk of cardiovascular events, including myocardial infarction. Recent evidence indicates that inorganic nitrate supplementation, which is abundant in certain vegetables, augments nitric oxide (NO) bioavailability and may have beneficial effects on walking, blood pressure, and vascular function in patients with PAD.

Objective

We sought to determine if short-term nitrate supplementation (via beetroot juice) improves peak treadmill time and coronary hyperemic responses to plantar flexion exercise relative to placebo (nitrate-depleted juice) in older patients with PAD. The primary endpoints were peak treadmill time and the peak coronary hyperemic response to plantar flexion exercise.

Methods

Eleven PAD patients (52–80 yr.; 9 men/2 women; Fontaine stage II) were randomized (double-blind) to either nitrate-rich (Beet-IT, 0.3 g inorganic nitrate twice/day; BRnitrate) or nitrate-depleted (Beet-IT, 0.04 g inorganic nitrate twice/day, BRplacebo) beetroot juice for 4 to 6 days, followed by a washout of 7 to 14 days before crossing over to the other treatment. Patients completed graded plantar flexion exercise with their most symptomatic leg to fatigue, followed by isometric handgrip until volitional fatigue at 40% of maximum on day 4 of supplementation, and a treadmill test to peak exertion 1–2 days later while continuing supplementation. Hemodynamics and exercise tolerance, and coronary blood flow velocity (CBV) responses were measured.

Results

Although peak walking time and claudication onset time during treadmill exercise did not differ significantly between BRplacebo and BRnitrate, the diastolic blood pressure response at the peak treadmill walking stage was significantly lower in the BRnitrate condition. Increases in CBV from baseline to peak plantar flexion exercise after BRplacebo and BRnitrate showed a trend for a greater increase in CBV at the peak workload of plantar flexion with BRnitrate (p = 0.06; Cohen’s d = 0.56).

Conclusion

Overall, these preliminary findings suggest that inorganic nitrate supplementation in PAD patients is safe, well-tolerated, and may improve the coronary hyperemic and blood pressure responses when their calf muscles are most predisposed to ischemia.

Clinical trial registration:https://clinicaltrials.gov/, identifier NCT02553733.
Navigating the straits: realizing the potential of proton FLASH through physics advances and further pre-clinical characterization
Authors: Fenwick John D. , Mayhew Christopher , Jolly Simon , Amos Richard A. , Hawkins Maria A.
Published: July 2024

Ultra-high dose-rate ‘FLASH’ radiotherapy may be a pivotal step forward for cancer treatment, widening the therapeutic window between radiation tumour killing and damage to neighbouring normal tissues. The extent of normal tissue sparing reported in pre-clinical FLASH studies typically corresponds to an increase in isotoxic dose-levels of 5–20%, though gains are larger at higher doses. Conditions currently thought necessary for FLASH normal tissue sparing are a dose-rate ≥40 Gy s-1, dose-per-fraction ≥5–10 Gy and irradiation duration ≤0.2–0.5 s. Cyclotron proton accelerators are the first clinical systems to be adapted to irradiate deep-seated tumours at FLASH dose-rates, but even using these machines it is challenging to meet the FLASH conditions. In this review we describe the challenges for delivering FLASH proton beam therapy, the compromises that ensue if these challenges are not addressed, and resulting dosimetric losses. Some of these losses are on the same scale as the gains from FLASH found pre-clinically. We therefore conclude that for FLASH to succeed clinically the challenges must be systematically overcome rather than accommodated, and we survey physical and pre-clinical routes for achieving this.
Exploring the effects of negative supervisory feedback on creativity among research and development personnel: challenge or threat?
Authors: Li Haihong , Zhang Jianwei , Bhutto Muhammad Yaseen , Ertz Myriam , Zhou Jie , Xuan Xingyu
Published: July 2024

Supervisory feedback to stimulate research and development (R&D) employee creativity is a management issue that concerns scholars and practitioners. However, there are divergences and contradictions regarding whether negative feedback promotes or hinders employee creativity. Integrating the feedback intervention and cognitive appraisal theories, we developed a double-edged sword model for negative supervisory feedback's influence on creativity. We tested the proposed model using a field sample of 513 R&D employees from seven science and technology enterprises. The results indicated that R&D employee challenge and threat appraisal moderated negative supervisory feedback's effect on prevention focus and the distal consequences for creativity. Individuals with high (low) levels of challenge (threat) appraisal have decreased prevention focus, thereby increasing their creativity when receiving negative supervisory feedback. In contrast, individuals with low (high) challenge (threat) appraisal have increased prevention focus, thereby decreasing their creativity when receiving negative supervisory feedback. These findings offer interesting implications for research on negative feedback and stimulation of science and technology R&D employee creativity in organizations.
The effects of age and gender and elite levels on perceptual–cognitive skills of adolescent badminton athletes
Authors: Wu Kuo-Cheng , Lee Yu-Lung , Chen Shiau-Cheng
Published: July 2024

Introduction

This study aimed to examine perceptual-cognitive skills across age, gender and elite levels of badminton adolescent athletes.

Methods

A total of 57 badminton athletes divided into junior high school athletes (age = 13.36 ± 1.14 years, females = 22, males = 11) and senior high school athletes (age = 16.25 ± 0.84 years, females = 11, males = 13) were evaluated using a cognitive component skills approach. Elite levels were classified as semi-elite (n = 29, score = 3.23) and competitive elite (n = 28, score = 5.84) levels. Each group completed a cognitive test, including an evaluation of their capacity for Corsi block-tapping (CCT) and spatial priming tasks (SPT).

Results

No gender effects were found in the perceptual skills of the adolescent players, and the age effect was consistent across gender. For the elite levels, the perceptual-cognitive skills of SPT of reaction time was performed equally in the groups of semi-elite and competitive players, however, in the CCT Span of working-memory (WM), competitive-elite players outperformed semi-elite players.

Conclusion

We found that perceptual-cognitive skills of WM play crucial roles in the open-skill sports of badminton. Thus, when developing advanced skills to higher elite levels in adolescent players, perceptual-cognitive skills should be considered.
Reviving health mediation during the COVID-19 crisis and beyond: an implementation study in deprived neighbourhoods of Marseille, France
Authors: Fruleux Alix , Gaudart Jean , Franke Florian , Nauleau Steve , Dutrey Kaiser Anne , Legendre Eva , Balma Dorothée , Lescaudron Marc , Tamalet Lucile , Malfait Philippe , Chaud Pascal , Rebaudet Stanislas
Published: July 2024

Introduction

In 2020, during France’s COVID-19 response, healthcare professionals from a hospital and an association initiated health mediation interventions in Marseille’s vulnerable neighbourhoods, funded by the regional health authorities. This mixed method research evaluates the CORHESAN program that lasted until June 2022.

Methods

We examined CORHESAN documents and reports, conducted interviews, and analysed activity data, comparing it to the COVID-19 hotspots identified on a weekly basis at the neighbourhood level, using generalised linear mixed models (GLMMs).

Results

CORHESAN was implemented by a team of up to nine health mediators, six private nurses hired on an ad hoc basis, supervised by a general coordinator and two part-time medical and nursing coordinators. Multiple partnerships were established with shelters, associations, social-housing landlords and local institutions. The team accompanied 6,253 people affected by COVID-19 or contact in the practical implementation of their isolation and contact tracing. Of the 5,180 nasopharyngeal samples for RT-PCR and 1,875 for antigenic testing: 12% were taken at home and 27% in partner facilities in the targeted neighbourhoods; 32% were taken from symptomatic patients and 30% in the context of contact tracing; and 40% were positive. Multiple awareness sessions on prevention methods and distributions of personal protection kits and self-diagnostic tests were conducted in the streets, in shelters, in associations or at home. A total of 5,929 doses of COVID-19 vaccine were administered in a walk-in vaccination centre, at temporary street vaccination posts, during operations at partner facilities, or during home-visits to patients with limited autonomy. GLMMs showed that the intervention significantly targeted its testing interventions in neighbourhoods with socioeconomic disadvantage and/or past under-testing (adjusted odds ratio (aOR), 2.75 [1.50–5.00]) and those with high hotspot level (aOR for level-3 versus level-0, 1.83 [1.24–2.71]).

Discussion

The pandemic emphasised the potential of health mediation interventions to address health disparities. Building on this, a new program began in July 2022, aiming at enhancing cancer screening and vaccinations in deprived areas of Marseille. Evaluations are ongoing to assess its activities and impact, and provide evidence to future implementation initiatives.
A network analysis of the interrelationships between depression, anxiety, insomnia and quality of life among fire service recruits
Authors: Liu Jian , Gui Zhen , Chen Pan , Cai Hong , Feng Yuan , Ho Tin-Ian , Rao Shu-Ying , Su Zhaohui , Cheung Teris , Ng Chee H. , Wang Gang , Xiang Yu-Tao
Published: July 2024

Background

Research on the mental health and quality of life (hereafter QOL) among fire service recruits after the end of the COVID-19 restrictions is lacking. This study explored the network structure of depression, anxiety and insomnia, and their interconnections with QOL among fire service recruits in the post-COVID-19 era.

Methods

This cross-sectional study used a consecutive sampling of fire service recruits across China. We measured the severity of depression, anxiety and insomnia symptoms, and overall QOL using the nine-item Patient Health Questionnaire (PHQ-9), seven-item Generalized Anxiety Disorder scale (GAD-7), Insomnia Severity Index (ISI) questionnaire, and World Health Organization Quality of Life-brief version (WHOQOL-BREF), respectively. We estimated the most central symptoms using the centrality index of expected influence (EI), and the symptoms connecting depression, anxiety and insomnia symptoms using bridge EI.

Results

In total, 1,560 fire service recruits participated in the study. The prevalence of depression (PHQ-9 ≥ 5) was 15.2% (95% CI: 13.5–17.1%), while the prevalence of anxiety (GAD-7 ≥ 5) was 11.2% (95% CI: 9.6–12.8%). GAD4 (“Trouble relaxing”) had the highest EI in the whole network model, followed by ISI5 (“Interference with daytime functioning”) and GAD6 (“Irritability”). In contrast, PHQ4 (“Fatigue”) had the highest bridge EI values in the network, followed by GAD4 (“Trouble relaxing”) and ISI5 (“Interference with daytime functioning”). Additionally, ISI4 “Sleep dissatisfaction” (average edge weight = −1.335), which was the central symptom with the highest intensity value, had the strongest negative correlation with QOL.

Conclusion

Depression and anxiety were important mental health issues to address among fire service recruits in the post-COVID-19 era in China. Targeting central and bridge symptoms identified in network analysis could help address depression and anxiety among fire service recruits in the post-COVID-19 era.
Promoting sustainable communities through affordable housing. A case study of Beirut, Lebanon
Authors: Mazzetto Silvia , El-Khoury Roula , Malkoun Joanna
Published: July 2024

Promoting sustainable communities aims at creating both environmentally and socially responsible living environments. This paper explores the role of affordable housing in promoting the long-term sustainability of a community within healthy living conditions by closely examining the relationship between affordable housing, urban development policies, and sustainability, with the capital of Lebanon, Beirut, serving as a case study. The first part of the paper focuses on the current building laws issued in the official newspaper in 2004 using a content analysis methodology to demonstrate the impact of the changes in the laws on the new morphology and social fabric of the city through the creation of a favorable environment for big developers, wealthy property owners, and real estate agencies and, at the expense of old city residents and low-income families. The second part of the paper uses the qualitative analysis methodology to justify the presence of large unused stock of residential units in Beirut, referring to information from multiple data sources selected based on their applicability to sustainable development, affordable housing, and urban planning in areas related to the case study, Beirut. This part then investigates the potential presented by this stock of residential units in Beirut to increase the supply of affordable housing and foster a sustainable community. This paper argues that the promoted vertical expansion of the city weighs heavily on the environment and fails to provide a diverse mix of housing units, excluding a significant portion of the community from the city. Alternative development models aligning with principles of sustainable development and challenging the current building laws can promote social inclusivity, reduce urban sprawl, and minimize environmental impacts associated with new constructions, thus preserving the city’s physical and social fabric.
The enhancement of water and energy conservation through condensed water reclamation for evaporative cooling towers
Authors: Leung Yiu-Kuen , Cheng Ka Wai Eric
Published: July 2024

Although environmental groups have declaimed the application of greywater to alleviate water consumption, the progress of condensed water implementation for high-rise buildings was still sluggish. As greywater demands wastewater treatment before any application, the novelty of this study was to demonstrate the direct use of condensed water in an existing cooling water system without wastewater treatment. Considering there is barely any practical case study research to unveil the water-energy nexus in reclaiming condensed water for evaporative cooling tower systems, this research has signified that condensed water is a simple and low-budget application for water conservation and energy saving. Given that the condensed water possesses an intrinsic impurity-free property, the water-saving potentials have been amplified to the most tolerable total dissolved solids (TDS) of system water. Furthermore, it is beneficial that water quality control ameliorated the operating working conditions, the system performances were improved, and then less power was consumed. By getting rid of the wastewater treatment, consolidating the feasibility of practical direct-use application, and its sustainability for water and energy saving, this research may revive the attention of green building claimers to expedite its implementation and tie in the green building design. The condensed water derived from the electric ventilation system was reclaimed as an alternative water source for cooling without extra power consumption, which was ideal for concentration dilution and beneficial to descaling. An evaporative cooling system consumes tons of water, and the water losses are necessarily compensated by fresh water; this process occurs gradually over time and progressively escalates the TDS with time, which evocates water scale formations. Although the bleed-off (BO) that discharges the impurity-laden system water effectively lowers the TDS, it is not a water conservation measure, and the chemical effluent poses environmental hazards. The higher cycles of concentration (CoC) reduce the frequency of BO and sustain the full efficacy of antiscaling chemicals. Whenever water scales appear as a resistance of heat transfer deposit on the heat exchangers, the heat management capability is diminished and energy efficiency drops. The water and energy saving enhancement method was accomplished by reclaiming the condensed water and setting higher CoC.
Drilling in an African Lake to Find Out Whether Climate Change Drove Human Evolution
Authors: Foerster Verena , Simon Marine , Schaebitz Frank
Published: July 2024

Why does drilling into a dried-out lake in eastern Africa get scientists excited? Simple answer: the lake’s sediments store valuable information about how past climate change shaped the environment where our earliest ancestors lived. Those sediments serve as a natural record of Earth’s ancient climate. While much is known about human evolution from fossil discoveries in eastern Africa, the role that climate change might have played for human biological and cultural evolution remained unclear for a long time. But now we have drilled 278 m into the ground at the bottom of the old Chew Bahir Lake in southern Ethiopia, which has given us some detailed answers. This natural record covers the last 620,000 years of climate history from one of the proven habitats of ancient Homo sapiens, and it can help us to unravel connections between climate and human evolution.
How Mom’s Diet Impacts Baby’s Gut Health
Authors: Jaleel Sana , Ramotar Priya , Daniel Sarah , Mirpuri Julie
Published: July 2024

What a mom eats before her baby is born can impact the baby’s development. In this experiment, we fed pregnant mice an unhealthy high-fat diet to see the effect on the intestines of the baby mice after they were born. We found that the babies had more of a certain type of immune cell and that their intestines were more easily damaged compared to babies whose moms ate a healthier diet. In the second part of the experiment, we blocked the effects of these unusual immune cells and saw that the intestines of these babies became more resistant to damage, almost like those of baby mice whose moms ate healthy diets. Our research shows how important it is for moms to eat healthy foods when they are pregnant, to keep the newborn baby’s gut healthy.
Assessment of the spatial distribution and identification of potential risk areas for the sterility mosaic disease of pigeonpea (Cajanus cajan L. Huth) in Southern India
Authors: Mediga Kasi Rao , Sunkad Gururaj , Shil Sandip , Kulkarni Sunil , Patil Balanagouda , Sharath Chandran U. S. , Ashwini P. , Sharma Mamta
Published: July 2024

Sterility mosaic disease (SMD) is an emerging biotic risk to the cultivation of pigeonpea throughout the Indian subcontinent. The prevalence and distribution of SMD documented from diverse agro-climatic zones are still poorly known. In this investigation, we determined the spatial distribution of SMD covering major pigeonpea-growing states of Southern India namely, Karnataka, Telangana, Tamil Nadu, Maharashtra, and Andhra Pradesh by considering 2 years of exploratory survey data. Geospatial approaches were employed to determine the SMD incidence levels at unvisited locations using neighboring observations. The results indicated enormous variability in disease incidence ranging from 0 to 82.64% and 0 to 36.84%, respectively, in Kharif 2021–22 and 2022–23 in pigeonpea-growing states. Spatial autocorrelation analysis and Ripley’s K function established the presence of average clustering over sampling locations. Two main clusters were identified via agglomerative hierarchical cluster analysis. From the Local Moran’s I spatial autocorrelation (LISA) analysis, most of the districts were clustered together at (I<0). From the p-values, Bidar and Krishnagiri districts recorded the highest spatial dependence, while the remaining districts recorded medium spatial dependence (p < 0.05). Based on kriging, the Chittoor district of Andhra Pradesh, Medak and Ranga Reddy districts of Telangana, Bijapur district of Karnataka, and Latur district in Maharashtra states were found to be vulnerable to SMD occurrence in the future. The Matern and Spherical models were shown to be the best of the several semivariogram experimental models tested for spatial patterns of SMD incidence, from which OK and IK maps were created. Based on the interpolation results, the potential SMD hotspots/risk areas were most prominent in Telangana, Andhra Pradesh, Karnataka, and Tamil Nadu states. These identified hotspots for SMD revealed high levels of disease probability rates (>25%) above the threshold level and must be closely monitored to restrict and minimize further disease spread across the studied areas in Southern India. In pigeonpea, this is the first study in India that attempted to understand the spatial pattern of SMD using geostatistical methodologies. The results of the study will aid in the design and dissemination of specific management practices and curb the further spread of SMD.