bluuebunny/crossref_metadata_2025 huggingface dataset:
Substrate‐Controlled Asymmetric Total Syntheses of Microcladallenes A, B, and C Based on the Proposed Structures
Authors: Sohn Te‐ik , Kim Deukjoon , Paton Robert S.
Published: September 2015

Substrate‐controlled asymmetric total syntheses of (+)‐microcladallenes A, B, and C have been accomplished based on the proposed structures. The syntheses of microcladallenes A and B confirmed the structures and absolute configurations of both natural products. However, the synthesis of microcladallene C, which includes seven stereogenic centers and an (R)‐bromoallene in its compact C15 framework, brought the realization that its proposed structure must be revised. The introduction of C12‐bromine into these natural products with retention of configuration relied on TiBr4‐mediated nucleophile‐assisting leaving group brominations, the stereochemical outcome of which could be attributed, at least in part, to an oxonium or halonium ion formation–fragmentation sequence through intricate neighboring group participation. In addition, the pivotal β‐oriented vicinal cis‐dichloride function in microcladallene C was elaborated through a novel tandem Cl2‐induced electrophilic cyclization/imidate chlorination process. The positive rotations of these natural products with an (R)‐bromoallene constitute exceptions to Lowe’s rule for reasons yet to be determined.
Copper‐Catalyzed Oxyboration of Unactivated Alkenes
Authors: Itoh Taisuke , Matsueda Takumi , Shimizu Yohei , Kanai Motomu
Published: September 2015

The first regiodivergent oxyboration of unactivated terminal alkenes is reported, using copper alkoxide as a catalyst, bis(pinacolato)diboron [(Bpin)2] as a boron source, and (2,2,6,6‐tetramethylpiperidin‐1‐yl)oxyl (TEMPO) as an oxygen source. The reaction is compatible with various functional groups. Two regioisomers are selectively produced by selecting the appropriate ligands on copper. The products may be used as a linchpin precursor for various other functionalizations, and net processes such as carbooxygenation, aminooxygenation, and dioxygenation of alkenes can be achieved after CB bond transformations. Mechanistic studies indicate that the reaction involves the following steps: 1) Transmetalation between CuOtBu and (Bpin)2 to generate a borylcopper species; 2) regiodivergent borylcupration of alkenes; 3) oxidation of the thus‐generated CCu bond to give an alkyl radical; 4) trapping of the resulting alkyl radical by TEMPO.
ChemInform Abstract: High Pressure Phase Transitions in Scheelite Structured Fluoride: ErLiF4.
Authors: Garg Nandini , Mishra A. K. , Poswal H. K. , Tyagi A. K. , Sharma Surinder M.
Published: September 2015

ErLiF4 is prepared by solid state reaction of stoichiometric amounts of LiF and ErF3 (1.
ChemInform Abstract: Monoclinically Distorted Perovskites, A2ZnTiO6 (A: Pr, Gd): Rietveld Refinement, and Dielectric Studies.
Authors: Das Nibedita , Nath Masood A. , Thakur Gohil S. , Thirumal M. , Ganguli Ashok K.
Published: September 2015

Pr2ZnTiO6 and Gd2ZnTiO6 are prepared by calcination of stoichiometric amounts of Pr6O11 or Gd2O3, TiO2 and ZnO (alumina crucible, staged heating at 1323, 1423, and 1523 K, 4 h each stage).
ChemInform Abstract: Electrochemical and Structural Study of Layered P2‐Type Na2/3Ni1/3Mn2/3O2 as Cathode Material for Sodium‐Ion Battery.
Authors: Wen Yanfen , Wang Bei , Zeng Guang , Nogita Kazuhiro , Ye Delai , Wang Lianzhou
Published: September 2015

The title material is prepared by coprecipitation from aqueous solutions containing MnSO4, NiSO4, Na2CO3, and NH4OH.
ChemInform Abstract: Isolation and Characterization of the [Ga2Al18O8(OH)36 (H2O)12]8+ Cluster: Cationic Variations on the Wells—Dawson Topology.
Authors: Fairley M. , Corum K. W. , Johns A. , Unruh D. K. , Basile M. , de Groot J. , Mason S. E. , Forbes T. Z.
Published: September 2015

A new heterometallic cluster, [Ga2Al18O8(OH)36 (H2O)12](nds)4·31H2O (nds: 2,7‐naphthalene disulfonate) is synthesized by heating a partially hydrolized aqueous solution of AlCl3 and GaCl3 with a Ga/Al ratio of 1:2 at 80 °C for 24 h in an autoclave followed by addition of Na2(nds) as a co‐crystallization agent (room temperature, 21 d, 30% yield).
ChemInform Abstract: The Vanadium(V) Oxoazides [VO(N3)3], [(bipy)VO(N3)3], and [VO(N3)5]2‐.
Authors: Haiges Ralf , Vasiliu Monica , Dixon David A. , Christe Karl O.
Published: September 2015

[VO(N3)3] is prepared by a fluoride‐azide exchange reaction between [VOF3] and Me3SiN3 in MeCN solution (evacuated Teflon FEP ampoule, ‐196 °C → ‐20 °C, 2 h, 94% yield) and subsequent removal of volatiles in vacuum at ‐20 °C and 25 °C [caution: polyazides are extremely shock‐sensitive and can explode violently].
ChemInform Abstract: 1D Pure Inorganic Helical Chain Framework Built upon Banana‐Shaped Molybdovanadates: Synthesis, Crystal Structure, and Magnetic Properties.
Authors: Gao Qiao , Li Fengyan , Xu Lin
Published: September 2015

The new compound (NH4)12[Na(H2O)5] [Na(H2O)2]2 [Fe5CoMo22V2O87(H2O)] ·19H2O is synthesized from an aqueous solution of (NH4)6Mo7O24, NaVO3, CoCl2, and NH4OH (pH 5.0), which is heated to about 90 °C followed by addition of FeCl3 (90 °C, 30 min, 23% yield).
ChemInform Abstract: Investigation of the La2O3—Nb2O5—WO3 Ternary Phase Diagram: Isolation and Crystal Structure Determination of the Original La3NbWO10 Material.
Authors: Vu T. D. , Barre M. , Adil K. , Jouanneaux A. , Suard E. , Goutenoire F.
Published: September 2015

Based on investigations of the La2O3‐WO3‐Nb2O5 ternary phase diagram, La3NbWO10 is newly discovered in samples prepared from stoichiometric amounts of La2O3, Nb2O5, and WO3 (alumina crucible, complex heating schedule with max.
ChemInform Abstract: Synthesis, Characterization, and Properties of Reduced Europium Molybdates and Tungstates.
Authors: Abeysinghe Dileka , Gerke Birgit , Morrison Gregory , Hsieh Chun H. , Smith Mark D. , Poettgen Rainer , Makris Thomas M. , zur Loye Hans‐Conrad
Published: September 2015

Single crystals of K0.094Eu0.906MoO4, K0.097Eu0.903WO4, EuWO4, and EuMoO4 are grown from molten KCl and CsCl fluxes using MoO3 (WO3) and Eu2O3 in the molar ratio of 2:1 with the in situ reductants Mo (W) and Zn (evacuated silica tubes, 850 °C (1000 °C for EuMoO4), 1 d (2 d for EuMoO4); cooling to 650 °C at a rate of 10 °C/min).
ChemInform Abstract: Anhydrous Manganese Hypophosphite Dense Framework Solid: Synthesis, Structure and Magnetic Studies.
Authors: Bhat Gulzar A. , Vishnoi Pratap , Gupta Sandeep K. , Murugavel Ramaswamy
Published: September 2015

Colorless crystals of [Mn(H2PO2)2]n·0.11DMF are solvothermally synthesized by reaction of MnCl2 with H3PO2 in a 8:1:1 (v/v) mixture of DMF, H2O, and EtOH (autoclave, 140 °C, 48 h, 60% yield).
ChemInform Abstract: (Pt1‐xCux)3Cu2B and Pt9Cu3B5, the First Examples of Copper Platinum Borides. Observation of Superconductivity in a Novel Boron Filled β‐Mn‐Type Compound.
Authors: Salamakha Leonid P. , Sologub Oksana , Stoeger Berthold , Michor Herwig , Bauer Ernst , Rogl Peter F.
Published: September 2015

(Pt1‐xCux)3Cu2B (x = 0.33) (I) and Pt9Cu3B5 (II) are prepared by repeated arc melting of the elements (Ta foil in evacuated quartz tubes, 600 °C, 240 h).
ChemInform Abstract: Synthesis of Phospholane—Phosphoramidite Ligands and Their Application in Asymmetric Catalysis.
Authors: Hammerer Tim , Leitner Walter , Francio Giancarlo
Published: September 2015

Ligand PPQ shows the best performance in the hydrogenations of olefines and imines as well as in the hydroformylation of styrenes among the title ligands.
ChemInform Abstract: Pd‐Catalyzed Asymmetric Allylic Amination with BOP Ligands and Its Applications to the Synthesis of Fused Polycyclic Alkaloids.
Authors: Zang Yang , Ojima Iwao
Published: September 2015

The allylic amination reaction of piperonylamides (I) with carbonate (II) in the presence of a chiral biphenol‐based diphosphinite ligand affords the corresponding piperonylamides (III) in high yields and enantioselectivities.
ChemInform Abstract: Catalytic Enantioselective Synthesis of N,Cα,Cα‐Trisubstituted α‐Amino Acid Derivatives Using 1H‐Imidazol‐4(5H)‐ones as Key Templates.
Authors: Etxabe Julen , Izquierdo Joseba , Landa Aitor , Oiarbide Mikel , Palomo Claudio
Published: September 2015

1H‐Imidazolones are reacted with nitroolefines and vinyl ketones in an enantioselective Michael reaction to trisubstituted amino acids.
ChemInform Abstract: Z‐Selective, Mg‐Mediated Synthesis of α,β‐Unsaturated‐β‐Iodo Morita—Baylis—Hillman‐Type Adducts
Authors: Bugarin Alejandro , Connell Brian T.
Published: September 2015

from aldehydes (II) and electron‐deficient alkynes (I)
ChemInform Abstract: Alkoxy‐Directed Cyclopropanation of 1,1‐Disubstituted Alkenes with Esters: New Approach to Quaternary Carbon Centers.
Authors: Rao Nagavaram Narsimha , Cha Jin Kun
Published: September 2015

A new approach to 1,2,2‐trisubstituted cyclopropanols (III) and (V) utilizing 3,3‐disubstituted homoallylic alcohols (I) and (IV) in the Kulinkovich cyclopropanation of esters (II) is reported.
ChemInform Abstract: Isomerization of Olefins Triggered by Rhodium‐Catalyzed C—H Bond Activation: Control of Endocyclic β‐Hydrogen Elimination.
Authors: Yip Stephanie Y. Y. , Aissa Christophe
Published: September 2015

4‐Pentenals isomerize to 3‐pentenals by rhodium catalysis.
ChemInform Abstract: Ring‐Closing Enyne Metathesis of Terminal Alkynes with Propargylic Hindrance.
Authors: Laroche Benjamin , Detraz Morgane , Blond Alain , Dubost Lionel , Mailliet Patrick , Nay Bastien
Published: September 2015

The title reaction is investigated in the presence of different Grubbs catalysts.
ChemInform Abstract: Multicomponent Reaction of 2‐Aminobenzimidazole, Arylglyoxals, and 1,3‐Cyclohexanedione.
Authors: Petrova Olesya N. , Zamigajlo Lali L. , Ostras Konstantin S. , Shishkina Svetlana V. , Shishkin Oleg V. , Borisov Alexander V. , Musatov Vladimir I. , Shirobokova Maria G. , Lipson Victoria V.
Published: September 2015

The title three‐component reaction provides access to Michael adducts and/or fused heterocyclic systems depending on the reaction conditions.
ChemInform Abstract: A New Synthesis of Polyfunctionalized 2‐Alkyl‐1,4‐diketones.
Authors: Palmieri Alessandro , Gabrielli Serena , Sampaolesi Susanna , Ballini Roberto
Published: September 2015

Functionalized polycarbonyl frameworks such as (III), (V), and (VII) are synthesized in very short time and maintaining the nitro functionality by reaction of silyl enol ethers with β‐nitroenones.
ChemInform Abstract: Trifluoroborane‐Catalyzed C—H Functionalization/S—H Insertion Reaction: Construction of N,S‐Acetal Quaternary Centers.
Authors: Cai Yan , Ge Haihong , Sun Weize , Miao Zhiwei
Published: September 2015

Mercaptans and thiophenols participate in the insertion reaction with carbenoids generated in situ from α‐diazophosphonates to produce N,S‐acetals containing quaternary centers.
ChemInform Abstract: Titanium Carbenoid‐Mediated Cyclopropanation of Allylic Alcohols: Selectivity and Mechanism.
Authors: Duran‐Pena M. J. , Botubol‐Ares J. M. , Hanson J. R. , Hernandez‐Galan R. , Collado I. G.
Published: September 2015

An unprecedented titanium carbenoid generated in situ from methylene diiodide, manganese, and Nugent′s reagent is assumed as key intermediate in the highly chemo‐ and diastereoselective cyclopropanation of allylic alcohols.
ChemInform Abstract: Hydrogenation of (N,N‐Disubstituted Aminomethyl)nitrobenzenes to (N,N‐Disubstituted Aminomethyl)anilines Catalyzed by Palladium—Nickel Bimetallic Nanoparticles.
Authors: Bao Hailin , Wang Dingsheng , Wang Xinyan , Cheng Chuanjie , Li Yadong , Hu Yuefei
Published: September 2015

A stable nanosized Pd‐Ni bimetallic catalyst is prepared by heating Raney‐Ni and Na2PdCl4 in water.
ChemInform Abstract: A New Arylation of Silyl Enol Ethers by Quinone Monoacetal Substitution.
Authors: Dohi Toshifumi , Kamitanaka Tohru , Takamuro Hitoho , Mishima Yusuke , Washimi Naohiko , Kita Yasuyuki
Published: September 2015

The developed method offers a mild metal‐catalyst‐free access to α‐arylated carbonyl products containing a 2‐phenol moiety.
ChemInform Abstract: Metal‐Free Chemoselective ortho‐C(sp2)—F Bond Hydroxylation and N‐Trifluoroacylation of Fluoroarylamines for Domino Synthesis of 2‐(N‐Trifluoroacyl)aminophenols.
Authors: Venkateswarlu Vunnam , Balgotra Shilpi , Aravinda Kumar K. A. , Vishwakarma Ram A. , Sawant Sanghapal D.
Published: September 2015

A novel method for the selective ortho‐directed monohydroxylation and concomitant N‐trifluoroacylation of 2‐ and 6‐fluoro‐ or 2,6‐difluoro‐substituted anilines is developed.
ChemInform Abstract: N‐Heterocyclic Carbene‐Catalyzed Aerobic Oxidation of Aryl Alkyl Alcohols to Carboxylic Acids.
Authors: Yu Dong‐Fang , Xing Ping , Jiang Biao
Published: September 2015

The metal‐free oxidation of benzylic alcohols by O2 in the presence of N‐heterocyclic carbenes affords aromatic carboxylic acids conveniently.
ChemInform Abstract: SN2 Displacement at the Quaternary Carbon Center: A Novel Entry to the Synthesis of α,α‐Disubstituted α‐Amino Acids.
Authors: Ishihara Kotaro , Hamamoto Hiromi , Matsugi Masato , Shioiri Takayuki
Published: September 2015

A novel method for the azidation on quaternary carbon atoms is reported.
ChemInform Abstract: Air Oxidative Radical Oxysulfurization of Alkynes Leading to α‐Thioaldehydes.
Authors: Zhou Shao‐Fang , Pan Xiang‐Qiang , Zhou Zhi‐Hao , Shoberu Adedamola , Zhang Pei‐Zhi , Zou Jian‐Ping
Published: September 2015

The method leads to the desired difunctionalized synthons which are of high interest in synthetic organic and medicinal chemistry.
ChemInform Abstract: Asymmetric Synthesis of Diarylmethane Derivatives by Dynamic Kinetic Resolution.
Authors: Gooch Lewis M. , Rossington Steven B. , Wilkinson James A.
Published: September 2015

Using the chiral ligand (‐)‐ sparteine as additive, the asymmetric allylation of ortho‐methoxydiphenylmethane (I) is carried out with e.e.
ChemInform Abstract: Propylphosphonic Anhydride (T3P) Mediated Synthesis of β‐Lactams from Imines and Aryl‐Substituted Acetic Acids.
Authors: Coulthard Graeme , Unsworth William P. , Taylor Richard J. K.
Published: September 2015

The products are generally delivered in high yields and with high to excellent trans‐selectivity.
ChemInform Abstract: Synthesis of 1,2,3‐Substituted Pyrroles from Propargylamines via a One‐Pot Tandem Enyne Cross Metathesis—Cyclization Reaction.
Authors: Chachignon Helene , Scalacci Nicolo , Petricci Elena , Castagnolo Daniele
Published: September 2015

The synthesis of all propargylamine substrates is described.
ChemInform Abstract: Enantioselective Hydroamination/Cyclization of Aminoalkenes by (Bis)‐C2 Symmetric and (Mono)‐C2 Symmetric Anionic Tetraamide Complexes of La(III).
Authors: Huynh Khoi , Anderson Bryon K. , Livinghouse Tom
Published: September 2015

It is demonstrated that anionic La(III)‐complexes (LAB) and (LAM) efficiently catalyze the enantioselective synthesis of pyrrolidines (II).
ChemInform Abstract: A Facile Synthesis of N‐Substituted 2,5‐Dimethylpyrroles with Saccharin as a Green Catalyst
Authors: Bhandari Namratha , Gaonkar Santosh L.
Published: September 2015

in the Paal—Knorr condensation
ChemInform Abstract: Catalytic Asymmetric Construction of Vicinal Tetrasubstituted Stereocenters by the Mannich Reaction of Linear α‐Substituted Monothiomalonates with Isatin N‐Boc Ketimines.
Authors: Liu Teng , Liu Weiwei , Li Xiaonian , Peng Fangzhi , Shao Zhihui
Published: September 2015

The method is highly enantio‐ and diastereoselective and affords less accessible 3‐aminooxindoles with vicinal tetrasubstituted stereocenters.
ChemInform Abstract: Rhodium‐Catalyzed Regioselective Direct C—H Arylation of Indoles with Aryl Boronic Acids.
Authors: Wang Liang , Qu Xing , Li Zhan , Peng Wang‐Ming
Published: September 2015

The arylation of indoles (I) and related substrates provides the corresponding 3‐substituted products in excellent yields and this reaction is compatible to a wide range of functionalized groups.
ChemInform Abstract: Rhenium‐Catalyzed [4 + 1] Annulation of Azobenzenes and Aldehydes via Isolable Cyclic Rhenium(I) Complexes.
Authors: Geng Xiaoyu , Wang Congyang
Published: September 2015

Optimized conditions under Re2(CO)10 catalysis lead to formation of various 2H‐indazoles.
ChemInform Abstract: Multidirectional Synthesis of Substituted Indazoles via Iridium‐Catalyzed C—H Borylation.
Authors: Sadler Scott A. , Hones Andrew C. , Roberts Bryan , Blakemore David , Marder Todd B. , Steel Patrick G.
Published: September 2015

In the absence of any steric directing group, the title reaction proceeds selectively at C‐3 of the indazole skeleton.
ChemInform Abstract: Intramolecular Cyclization of Alkylimidazoles.
Authors: Joshi Madhur S. , Lansakara Ashabha I. , Pigge F. Christopher
Published: September 2015

1,2‐Dialkylimidazoles are converted to nucleophilic 2‐alkylidene imidazoles upon treatment with Boc2O.
ChemInform Abstract: Cu‐Catalyzed sp3 C—H Bond Oxidative Functionalization of Alkylazaarenes and Substituted Ethanones: An Efficient Approach to Isoxazoline Derivatives.
Authors: Wang Gang‐Wei , Li Shi‐Xia , Wu Quan‐Xiang , Yang Shang‐Dong
Published: September 2015

2‐Methylpyridine, 3‐ and 4‐methylquinolines give only trace amounts of the desired product or fail in the reaction.
ChemInform Abstract: Efficient Assembly of Mono‐ and Bis(1,2,4‐oxadiazol‐3‐yl)furoxan Scaffolds via Tandem Reactions of Furoxanylamidoximes.
Authors: Fershtat Leonid L. , Ananyev Ivan V. , Makhova Nina N.
Published: September 2015

Tandem heterocyclization of furoxanylamidoximes with a diversity of carboxylic acid chlorides is efficiently achieved under mild reaction conditions to give oxadiazol‐3‐yl furoxans in good yields.
ChemInform Abstract: Regio‐ and Stereoselective Synthesis of α‐Hydroxy‐β‐azido Tetrazoles.
Authors: Couty Francois , Quinodoz Pierre , Lo Cheikh , Kletskii Mikhail , Burov Oleg , Marrot Jerome
Published: September 2015

The Bu2SnO2‐mediated concomitant cycloaddition/ring‐opening azidolysis reaction of α,β‐epoxy nitriles with trimethylsilyl azide provides the title compounds in a regio‐ and stereoselective manner.
ChemInform Abstract: Enantioselective Synthesis of Dihydropyran‐Fused Indoles Through [4 + 2] Cycloaddition Between Allenoates and 3‐Olefinic Oxindoles.
Authors: Wang Feng , Li Zhen , Wang Jie , Li Xin , Cheng Jin‐Pei
Published: September 2015

About 20 target ring structures are prepared from 3‐olefinic oxindoles.
ChemInform Abstract: L‐Proline Nitrate: A Recyclable and Green Catalyst for the Synthesis of Highly Functionalized Piperidines.
Authors: Agrawal Nikita R. , Bahekar Sandeep P. , Sarode Prashant B. , Zade Sanjio S. , Chandak Hemant S.
Published: September 2015

The application of the ionic liquid L‐proline nitrate as catalyst for the pseudo‐five component reaction of aromatic aldehydes, anilines, and β‐dicarbonyl compounds is demonstrated.
ChemInform Abstract: Tandem Synthesis of Pyrroloisoquinolines Through 5‐endo Iodolactamization, Oxidative Functionalization and α‐Amidoalkylation Reaction.
Authors: Tang Yu , Han Ranran , Lv Mingcan , Chen Yang , Yang Pan
Published: September 2015

The reaction can be performed in two separate steps or in one pot.
ChemInform Abstract: A Versatile Synthesis of Novel pan‐PIM Kinase Inhibitors with Initial SAR Study.
Authors: Flanders Yvonne , Dumas Stephane , Caserta Justin , Nicewonger Robb , Baldino Michael , Lee Chee‐Seng , Baldino Carmen M.
Published: September 2015

The synthesis of a series of novel inhibitors of the PIM family of kinases is described.
ChemInform Abstract: Studies Toward the Synthesis of Cinachyramine. An Efficient Route to 1,5‐Diazabicyclo[4.4.0]dec‐5‐enes.
Authors: Barykina‐Tassa Olga V. , Snider Barry B.
Published: September 2015

Hydrogenation of readily available pyrido[1,2‐a]pyrimidinium salts (I) over a Rh‐catalyst forms title compounds (II) in high yields, providing a general route to this little‐studied class of compounds.
ChemInform Abstract: Microwave‐Assisted Synthesis of New Quinazolinone and (Dihydroquinazolinylphenyl)oxazolone Derivatives.
Authors: Fozooni Samieh , Firoozi Halime
Published: September 2015

Microwave‐assisted three‐component reaction of isatoic anhydride (I) with hippuric acid (II) and aromatic aldehydes affords the new quinazolinone derivatives (IV), which react with aromatic aldehydes under microwave irradiation conditions to give oxazole derivatives (VI).
ChemInform Abstract: Synthesis of [1,2]Dithiolo[3,4‐b]pyridines via the Reaction of Dithiomalondianilide with Arylmethylidenemalononitriles.
Authors: Dotsenko Victor V. , Krivokolysko Sergey G. , Frolov Konstantin A. , Chigorina Elena A. , Polovinko Vitaliy V. , Dmitrienko Artem O. , Bushmarinov Ivan S.
Published: September 2015

A novel one‐pot procedure for accessing the comparatively little studied title compounds (III) is reported.
ChemInform Abstract: Vilsmeier Reagent‐Mediated Synthesis of 6‐[(Formyloxy)methyl]‐pyrazolopyrimidines via a One‐Pot Multiple Tandem Reaction.
Authors: Lu Shi‐Han , Liu Po‐Lin , Wong Fung Fuh
Published: September 2015

Chloroacetylaminopyrazoles of type (I) react with formamide in the presence of PBr3 via Vilsmeier type intermediates to give pyrazolopyrimidines having a O‐formylhydroxymethyl side chain.
ChemInform Abstract: Dual Roles of β‐Oxodithioesters in the Copper‐Catalyzed Synthesis of Benzo[e]pyrazolo[1,5‐c][1,3]thiazine Derivatives.
Authors: Wen Li‐Rong , Yuan Wen‐Kui , Li Ming
Published: September 2015

The mild and efficient procedure affords a series of pharmaceutically interesting title heterocycles bearing a broad spectrum of functionalities and a (Z) configurated side chain.
ChemInform Abstract: Radical Isomerization of Borylated Allylic Sulfones.
Authors: Altenhofer Erich , Harmata Michael
Published: September 2015

The radical isomerization of borylated allylic sulfones such as (I), (V), and (VII) to their thermodynamically more stable isomers (III)/(IV), (VI), and (VIII), resp., is reported.
ChemInform Abstract: Synthesis of Silafluorenes and Silaindenes via Silyl Radicals from Arylhydrosilanes: Intramolecular Cyclization and Intermolecular Annulation with Alkynes.
Authors: Xu Liang , Zhang Shuai , Li Pengfei
Published: September 2015

Diarylacetylenes perform well in the intermolecular annulation while dipropyl‐ as well as di(2‐thienyl)acetylenes give only low yields.
ChemInform Abstract: Natural Thioredoxin Reductase Inhibitors from Jatropha integerrima.
Authors: Zhu Jian‐Yong , Lou Lan‐Lan , Guo Yan‐Qiong , Li Wei , Guo Yan‐Hong , Bao Jing‐Mei , Tang Gui‐Hua , Bu Xian‐Zhang , Yin Sheng
Published: September 2015

Nine new diterpenoids including seven lathyranes [cf.
ChemInform Abstract: A Solvent‐Free Approach to Glycosyl Amides: Toward the Synthesis of α‐N‐Galactosyl Ceramides.
Authors: Chennamadhavuni Divya , Howell Amy R.
Published: September 2015

Reduction of glycosyl azides to amines followed by coupling with p‐nitrophenol esters of lipids as key step provides α‐ and β‐glycosyl amides.
ChemInform Abstract: Understanding the Outstanding Power Conversion Efficiency of Perovskite‐Based Solar Cells
Authors: Collavini Silvia , Voelker Sebastian F. , Delgado Juan Luis
Published: September 2015

Review: [11 refs.
ChemInform Abstract: Emerging Trends in Bio‐Synthesis and Applications of Gold Nanoparticles: a Blooming Technology
Authors: Shidhaye Supriya S. , Budhkar Tejal S. , Surve Chaitali V. , Dhone Ashwini G.
Published: September 2015

Review: 26 refs.
ChemInform Abstract: Ferroelectric‐Based Catalysis: Switchable Surface Chemistry
Authors: Kakekhani Arvin , Ismail‐Beigi Sohrab
Published: September 2015

Review: 138 refs.
ChemInform Abstract: Correlating Structure and Function of Metal Nanoparticles for Catalysis
Authors: Zhang Liang , Anderson Rachel M. , Crooks Richard M. , Henkelman Graeme
Published: September 2015

Review: 48 refs.
ChemInform Abstract: Green Chemistry Based Benign Routes for Nanoparticle Synthesis
Authors: Malik Parth , Shankar Ravi , Malik Vibhuti , Sharma Nitin , Mukherjee Tapan Kumar
Published: September 2015

Review: 82 refs.
ChemInform Abstract: Exploration of New Superconductors and Functional Materials and Fabrication of Superconducting Tapes and Wires of Iron Pnictides
Authors: Hosono Hideo , Tanabe Keiichi , Takayama‐Muromachi Eiji , Kageyama Hiroshi , Yamanaka Shoji , Kumakura Hiroshi , Nahara Minoru , Hiramatsu Hidenori , Fujitsu Satoru
Published: September 2015

Review: 536 refs.
ChemInform Abstract: Modelling Binuclear Metallobiosites: Insights from Pyrazole‐Supported Biomimetic and Bioinspired Complexes
Authors: Dalle Kristian E. , Meyer Franc
Published: September 2015

Review: 134 refs.
ChemInform Abstract: Latest Developments in Metalloenzyme Design and Repurposing
Authors: Heinisch Tillmann , Ward Thomas R.
Published: September 2015

Review: 89 refs.
ChemInform Abstract: Methods for the Synthesis of 1‐Substituted 1H‐imidazol‐2(3H)‐ones
Authors: Antonova Maria M. , Baranov Vladimir V. , Kravchenko Angelina N.
Published: September 2015

Review: 118 refs.
ChemInform Abstract: Investigations of the Chemistry of Alkyl Phosphites Toward Nitrogen‐Containing Compounds: Efficient Approaches to α‐Amino‐, β‐Amino‐, and/or Enaminophosphonates
Authors: Abdou Wafaa M. , Barghash Reham F. , Bekheit Mohamed S.
Published: September 2015

Review: [183 refs.
ChemInform Abstract: Designing P*‐Chirogenic Organophosphorus Compounds: From Ligands to Organocatalysts
Authors: Juge Sylvain
Published: September 2015

Review: 90 refs.
ChemInform Abstract: π‐Rich σ2P‐Heterocycles: Syntheses, Reactivity, and Application Potential of 1,3‐Benzazaphospholes
Authors: Heinicke Joachim W. , Ghalib Mohammed , Niaz Basit , Jones Peter G.
Published: September 2015

Review: 11 refs.
ChemInform Abstract: Lithiated Oxazolinyloxiranes and Oxazolinylaziridines: Key Players in Organic Synthesis
Authors: Florio Saverio , Degennaro Leonardo , Mansueto Rosmara , Musio Biagia , Perna Filippo M. , Salomone Antonio
Published: September 2015

Review: 59 refs.
ChemInform Abstract: Rearrangement Reactions for the Synthesis of Some Oxa‐ and Azatricyclic Ring Heterocyclic Compounds
Authors: Torincsi Mercedesz , Hornyanszky Gabor , Kolonits Pal , Novak Lajos
Published: September 2015

Review: 49 refs.
ChemInform Abstract: Catalytic Asymmetric Hydrogenation of Heteroarenes and Arenes
Authors: Kuwano Ryoichi
Published: September 2015

Review: 12 refs.
ChemInform Abstract: Use of EPR Spectroscopy to Unravel Reaction Mechanisms in (Catalytic) Bond Activation Reactions: Some Selected Examples
Authors: Manck Sinja , Sarkar Biprajit
Published: September 2015

Review: 92 refs.
ChemInform Abstract: Controlling the Activities of the Diiron Centre in Bacterial Monooxygenases: Lessons from Mutagenesis and Biodiversity
Authors: Nichol Tim , Murrell J. Colin , Smith Thomas J.
Published: September 2015

Review: 56 refs.
ChemInform Abstract: Cyclin Dependent Kinase (CDK) Inhibitors as Anticancer Drugs
Authors: Sanchez‐Martinez Concepcion , Gelbert Lawrence M. , Lallena Maria Jose , de Dios Alfonso
Published: September 2015

Review: 78 refs.
ChemInform Abstract: Rational Modification of the Biological Profile of GPCR Ligands Through Combination with Other Biologically Active Moieties
Authors: Huang Guozheng , Nimczick Martin , Decker Michael
Published: September 2015

Review: 99 refs.
ChemInform Abstract: Recent Strategies to Develop Self‐Healable Crosslinked Polymeric Networks
Authors: An So Young , Arunbabu Dhamodaran , Noh Seung Man , Song Young Kyu , Oh Jung Kwon
Published: September 2015

Review: 141 refs.
ChemInform Abstract: Perovskite Photovoltaics: Rare Functions of Organo Lead Halide in Solar Cells and Optoelectronic Devices
Authors: Miyasaka Tsutomu
Published: September 2015

Review: [87 refs.
ChemInform Abstract: A Multidisciplinary Approach to Understand the Interactions of Nonthermal Plasma and Catalyst: A Review
Authors: Kim Hyun‐Ha , Teramoto Yoshiyuki , Negishi Nobuaki , Ogata Atsushi
Published: September 2015

Review: 140 refs.
ChemInform Abstract: Limitations and Extensions of the Lock‐and‐Key Principle: Differences Between Gas State, Solution and Solid State Structures
Authors: Schneider Hans‐Joerg
Published: September 2015

Review: 124 refs.
ChemInform Abstract: Rhodium Complexes in Homogeneous Catalytic Systems for Oxidative Functionalization of Alkanes: Experiment and Quantum‐chemical Calculations
Authors: Chepaikin E. G. , Borshch V. N.
Published: September 2015

Review: 71 refs.
Superficially Porous Particle Based Hydroxypropyl‐β‐cyclodextrin Stationary Phase for High‐Efficiency Enantiomeric Separations
Authors: Spudeit Daniel A. , Breitbach Zachary S. , Dolzan Maressa D. , Micke Gustavo A. , Armstrong Daniel W.
Published: September 2015

A superficially porous particle (SPP)‐based hydroxypropyl‐β‐cyclodextrin (HPBCD) chiral stationary phase (CSP) was produced and its chromatographic performance was compared to both 5 µm and 3 µm fully porous particle (FPP)‐based CSPs. The relative surface coverage of the HPBCD chiral selector on each particle was approximately equal, which resulted in equivalent enantiomeric selectivity (α) values on each phase when constant mobile phase conditions were used. Under such conditions, the SPP column resulted in greatly reduced analysis times and three times greater efficiencies compared to the FPP columns. When higher flow rates were used, efficiency gains per analysis times were five times greater for the SPP column compared to the FPP‐based columns. When the mobile phases were altered to give similar analysis times on each column, resolution values were doubled for the SPP column. Finally, the novel SPP based HPBCD column proved to be stable for 500 injections under high flow rate (4.5 mL/min) and high pressure (400 bar) conditions used for an ultrafast (~45 sec) enantiomeric separation. Chirality 27:788–794, 2015. © 2015 Wiley Periodicals, Inc.
Direktsynthese von Bioethylen aus Weizenstroh
Authors: Steffien Doreen , Roßberg Christine , Kiehle Rica , Bremer Martina , Fischer Steffen , Bertau Martin
Published: September 2015

Die Konversion von Lignocellulose in Ethylen führt zu einer bis zu dreimal höheren Wertschöpfung gegenüber Bioethanol. Voraussetzung ist der direkte Zugang zu Bioethylen ohne vorangehende Isolierung des Ethanols. Erreicht wurde dies durch eine Vorbehandlung von Weizenstroh mit Natronlauge. Bei der anschließenden simultanen Verzuckerung und Fermentation (SSF) mit dem Cellulasekomplex aus Penicillium verruculosum wurden bei Verwendung von Saccharomyces cerevisiae L13 Ethanolgehalte von ca. 13 Vol.‐% erreicht. Durch Strippen der Fermentationsbrühe mit N2 wurde ohne weitere Aufarbeitung und Reinigungsoperation am ZSM‐5‐Kontakt quantitativ Ethylen erhalten.
Processing of Grinding Slurries Arising from NdFeB Magnet Production
Authors: Kruse Stephanie , Raulf Karoline , Trentmann Anna , Pretz Thomas , Friedrich Bernd
Published: September 2015

Neodymium‐iron‐boron (NdFeB) grinding slurries are the residual output of grinding as shaping process step in the production process of sintered NdFeB magnets. The treatment of the grinding slurries with the aim of recovering rare earth elements may lead to a reduced demand in primary raw materials like the rare earth elements neodymium, praseodymium and dysprosium. In this study, the possibility of recycling the contained rare earth elements, which account for up to 30 wt % in the alloy, through a pyrometallurgical process was investigated. The necessity of a thermal conditioning prior to the pyrometallurgical process is described.
Application of irreversible thermodynamics to the solvent diffusion in an amorphous glassy polymer: A comprehensive model for drying of toluene‐poly(methyl methacrylate) coatings
Authors: Verros George D.
Published: September 2015

In this work a comprehensive framework for modelling solvent‐polymer mutual diffusion coefficient in the glassy state is proposed. This framework is based on irreversible thermodynamics. In particular, an appropriate transformation is used to show that case‐II diffusion appearing in the glassy state could be reduced to a close‐to‐equilibrium rubbery state where typical equations relating the solvent‐polymer mutual diffusion coefficient with chemical potential and the solvent self‐diffusion coefficient are available. Moreover, this theory is applied to solvent evaporation from a toluene‐poly(methyl methacrylate) film. The toluene evaporation process is modelled as a coupled heat and mass problem with a moving boundary. Model predictions were found to be in satisfactory agreement with available experimental data. It is believed that this work could be used to further study solvent diffusion in the glassy polymer state.
Cation‐assisted adsorption of chlorophenols by nano‐xerogels
Authors: Hassani Sorour , Ghasemi Awat , Fazli Mostafa , Haghbeen Kamahldin , Legge Raymond L.
Published: September 2015

With water quality deteriorating globally, identification of novel adsorbents for removal of chloroaromatic compounds for wastewater treatment is of growing interest. Classic xerogels produced by drying sol‐gels of tetraalkoxy silanes, such as tetramethoxy orthosilane (TMOS) or tetraethoxy orthosilane (TEOS), carry a negative surface charge in water when the pH is higher than the Point of Zero Charge (PZC). This feature was employed in this study to load divalent metal cations on the surfaces of these materials to facilitate chlorophenol (CP) adsorption. Although classic xerogels do not show a high affinity for the adsorption of chlorophenols such as 2‐chlorophenol (2CP) in aqueous media, TEOS xerogels loaded with the cations Ni2+, Cd2+, and Zn2+ showed 225, 249, and 306 % increases, respectively, in the adsorption of 2CP compared to the unloaded TEOS xerogel. Adsorption of the divalent cations on the xerogels exhibited the order of Zn2+ > Cd2+ > Ni2+, with maximum adsorption capacities (Q°) of 15.9 and 13 mg/g for Zn2+ on TEOS and TMOS xerogels, respectively. Using TEOS xerogels loaded with Zn2+ (TEOS‐Zn), adsorption of 2CP, 2,4‐dichlorophenol (DCP), and 2,4,6‐trichlorophenol (TCP) in aqueous media was studied. The adsorption was found to be spontaneous and obeyed pseudo‐second order kinetics, suggesting a chemisorption mechanism between CP and TEOS‐Zn. The equilibrium isothermal adsorption data were most closely fitted with a Langmuir equation resulting in Q° values of 13.9, 9.17, and 8.5 mg/g for 2CP, DCP, and TCP, respectively.
Free fall and controlled gravity drainage processes in fractured porous media: Laboratory and modelling investigation
Authors: Saedi Benyamin , Ayatollahi Shahab , Masihi Mohsen
Published: September 2015

Gravity drainage is known to be one of the most effective methods for oil recovery in fractured reservoirs. In this study, both free fall and controlled gravity drainage processes were studied using a transparent fractured experimental model, followed by modelling using commercial CFD software. The governing equations were employed based on the Darcy and mass conservation laws and partial pressure formulation. Comprehensive examination was done on variables such as fluid saturation, velocity, and pressure distribution in the matrix and fracture, as well as fluid front level and production rate. Additionally, effects of the model parameters on the gravity drainage performance were investigated. The experimental results confirmed a higher oil recovery factor at breakthrough for lower production rates in the controlled gravity drainage. Satisfactory agreement was observed between the experimental data and modelling results.
Ag on Pt(111): Changes in Electronic and CO Adsorption Properties upon PtAg/Pt(111) Monolayer Surface Alloy Formation
Authors: Diemant Thomas , Schüttler Konstantin M. , Behm R. Jürgen
Published: September 2015

The front cover artwork is provided by T. Diemant, K. M. Schüttler, and R. J. Behm, Ulm University, Germany. Using the example of CO desorption, the image illustrates the changes of the electronic and chemical properties of a bimetallic PtAg surface when going from a Ag film/Pt(111) to a PtAg/Pt(111) surface alloy. Read the full text of the article at 10.1002/cphc.201500528
Investigation of DOTA–Metal Chelation Effects on the Chemical Shift of 129Xe
Authors: Jeong Keunhong , Slack Clancy C. , Vassiliou Christophoros C. , Dao Phuong , Gomes Muller D. , Kennedy Daniel J. , Truxal Ashley E. , Sperling Lindsay J. , Francis Matthew B. , Wemmer David E. , Pines Alexander
Published: September 2015

Recent work has shown that xenon chemical shifts in cryptophane‐cage sensors are affected when tethered chelators bind to metals. Here, we explore the xenon shifts in response to a wide range of metal ions binding to diastereomeric forms of 1,4,7,10‐tetraazacyclododecane‐1,4,7,10‐tetraacetic acid (DOTA) linked to cryptophane‐A. The shifts induced by the binding of Ca2+, Cu2+, Ce3+, Zn2+, Cd2+, Ni2+, Co2+, Cr2+, Fe3+, and Hg2+ are distinct. In addition, the different responses of the diastereomers for the same metal ion indicate that shifts are affected by partial folding with a correlation between the expected coordination number of the metal in the DOTA complex and the chemical shift of 129Xe. These sensors may be used to detect and quantify many important metal ions, and a better understanding of the basis for the induced shifts could enhance future designs.
Industry perspectives on biomarker qualification
Authors: Lavezzari G , Womack AW
Published: September 2015

Biomarkers have the potential to expedite drug development, increase patient safety, and optimize clinical response. Yet few have achieved regulatory qualification. A survey was conducted to clarify industry's perspective on biomarker qualification and identify the most promising biomarkers for drug development. The results across toxicities/clinical areas highlight challenges in regulatory qualification, although early prioritization and alignment on an evidentiary standard framework are key factors in facilitating biomarker development and qualification.
Polymer Electrolyte Membrane Electrolyzers Utilizing Non‐precious Mo‐based Hydrogen Evolution Catalysts
Authors: Ng Jia Wei Desmond , Hellstern Thomas R. , Kibsgaard Jakob , Hinckley Allison C. , Benck Jesse D. , Jaramillo Thomas F.
Published: September 2015

The development of low‐cost hydrogen evolution reaction (HER) catalysts that can be readily integrated into electrolyzers is critical if H2 from renewable electricity‐powered electrolysis is to compete cost effectively with steam reforming. Herein, we report three distinct earth‐abundant Mo‐based catalysts, namely those based on MoSx, [Mo3S13]2− nanoclusters, and sulfur‐doped Mo phosphide (MoP|S), loaded onto carbon supports. The catalysts were synthesized through facile impregnation–sulfidization routes specifically designed for catalyst‐device compatibility. Fundamental electrochemical studies demonstrate the excellent HER activity and stability of the Mo‐sulfide based catalysts in an acidic environment, and the resulting polymer electrolyte membrane (PEM) electrolyzers that integrate these catalysts exhibit high efficiency and durability. This work is an important step towards the goal of replacing Pt with earth‐abundant catalysts for the HER in commercial PEM electrolyzers.
Antimony Doping in Solution‐processed Cu2ZnSn(S,Se)4 Solar Cells
Authors: Tai Kong Fai , Fu Dongchuan , Chiam Sing Yang , Huan Cheng Hon Alfred , Batabyal Sudip Kumar , Wong Lydia Helena
Published: September 2015

Kesterite Cu2ZnSn(S,Se)4 (CZTSSe) is obtained using a facile precursor‐solution method followed by selenization. Power‐conversion efficiency of 6.0 % is achieved and further improved to 8.2 % after doping the absorber with 0.5 mol % Sb. XRD and Raman spectroscopy show similar characteristics for the undoped and doped CZTSSe. Increasing the Sb concentration increases the grain size and lowers the series resistance. However, further Sb doping beyond 0.5 mol % degrades device performance due to lower open‐circuit voltage (and therefore lower fill factor). The effect of Sb doping and the doping concentration are investigated by power‐dependent and temperature‐dependent photoluminescence studies, revealing that trap density is significant reduced with 0.5 mol % Sb doping. Additional doping beyond 0.5 mol % creates more defects that quench the photoexcited carriers and decrease the open‐circuit voltage.
Double‐frequency buck converter as a candidate topology for integrated envelope elimination and restoration applications in power supply of RFPAs
Authors: Saberkari Alireza , Shirmohammadli Vahideh , Martinez Herminio , Alarcón Eduard
Published: September 2015

This paper proposes the use of double‐frequency (DF) buck converter architecture consisting of a merged structure of high and low frequency buck cells as a candidate topology for envelope elimination and restoration (EER) applications and integrated power supply of RF power amplifiers (RFPA) to obtain favorable tradeoffs in terms of efficiency, switching ripple, bandwidth, and tracking capability. It is shown that having two degrees of freedom in designing the DF buck helps to achieve high efficiency, low output ripples, and tracking capability with low ripples, simultaneously. A comparison analysis is done with regards to the mentioned performance indexes with the standard and three‐level buck converters; in addition, the results are validated in HSPICE in BSIM3V3 0.35‐µm CMOS process. Copyright © 2015 John Wiley & Sons, Ltd.
Family stress moderates relations between physiological and behavioral synchrony and child self‐regulation in mother–preschooler dyads
Authors: Suveg Cynthia , Shaffer Anne , Davis Molly
Published: September 2015

From a bio‐behavioral framework, the relations between physiological synchrony, positive behavioral synchrony, and child self‐regulation under varying levels of risk were examined among 93 mother‐ (M age = 30.44 years, SD = 5.98 years) preschooler (M age = 3.47 years, SD =.52 years, 58.70% male) dyads. Physiological synchrony was examined using interbeat interval (IBI) data and measures of positive behavioral synchrony and self‐regulation were based on observations of a mother–child interaction task. Results supported the phenomenon of physiological synchrony among mother–preschooler dyads during an interaction, but not a baseline, task. Moderation analyses indicated that under conditions of high family risk, positive behavioral synchrony and child self‐regulation were greater when physiological synchrony was low. Positive behavioral synchrony was positively associated with child self‐regulation, regardless of risk status. The results document physiological synchrony among mothers and their preschool‐aged children and the complex ways that physiological attunement relates to important developmental processes. © 2015 Wiley Periodicals, Inc. Dev Psychobiol 58:83–97, 2016.
Positive correlation of plasma PCSK9 levels with HbA1c in patients with type 2 diabetes
Authors: Yang Sheng‐Hua , Li Sha , Zhang Yan , Xu Rui‐Xia , Guo Yuan‐Lin , Zhu Cheng‐Gang , Wu Na‐Qiong , Cui Chuan‐Jue , Sun Jing , Li Jian‐Jun
Published: September 2015

Background

Proprotein convertase subtilisin/kexin type 9 (PCSK9) has been demonstrated to be involved in not only lipid metabolism but also glucose homeostasis. Glycated haemoglobin (HbA1c) is a ‘gold standard’ for monitoring long‐term glycaemic control. However, the correlation of plasma PCSK9 levels with HbA1c remains undetermined.

Methods

We consecutively enrolled 805 subjects undergoing coronary angiography, including 176 patients with type 2 diabetes mellitus (T2DM) and 629 non‐diabetic patients. The baseline characteristics were collected, and serum PCSK9 level was assessed by ELISA. Univariable regression analysis and multiple‐variable regression analysis were used to examine the associations of PCSK9 with HbA1c. Furthermore, the HbA1c was compared across the tertiles of PCSK9 levels. And also, PCSK9 levels were compared in poorly controlled (HbA1c ≥ 7.0%) and well‐controlled (HbA1c < 7.0%) patients with T2DM.

Results

PCSK9 levels were positively correlated with low‐density lipoprotein cholesterol in both T2DM and non‐T2DM. Univariable regression analysis revealed a positive association between PCSK9 and HbA1c in patients with T2DM (β = 0.255, p = 0.001) but not in patients without diabetes (β = 0.061, p = 0.128). Multiple‐variable regression analysis exhibited that PCSK9 was independently correlated with HbA1c in T2DM after adjustment for traditional atherosclerotic risk factors (β = 0.197, p = 0.020). Moreover, HbA1c level was higher in patients with the highest tertile of PCSK9 than that in the lowest tertile (p = 0.042). Additionally, higher levels of PCSK9 were found in poorly controlled group compared with the well‐controlled group (p = 0.029).

Conclusions

Data suggest a positive correlation of PCSK9 levels with HbA1c in patients with T2DM but not in patients without T2DM, indicating a potential role of PCSK9 in T2DM. Copyright © 2015 John Wiley & Sons, Ltd.
Essential phospholipids prevent islet damage induced by proinflammatory cytokines and hypoxic conditions
Authors: Shahbazov Rauf , Kanak Mazhar A. , Takita Morihito , Kunnathodi Faisal , Khan Omar , Borenstein Nofit , Lawrence Michael C. , Levy Marlon F. , Naziruddin Bashoo
Published: September 2015

Background

The pancreatic islet damage that occurs through an inflammatory response and hypoxia after infusion is a major hurdle in islet transplantation. Because essential phospholipids (EPL) have been shown to exhibit anti‐inflammatory properties in liver disease, we analysed their protective effect on islets in inflammatory or hypoxic conditions.

Methods

We evaluated the viability of mouse and human islets cultured with cytokines or in hypoxic conditions for 48 h and measured cytokine expression in islets by quantitative polymerase chain reaction. We then employed an in vivo mouse assay, transplanting a marginal dose of human islets treated with or without EPL into the subcapsule of the kidney in diabetic nude mice and determining the cure rate.

Results

The viability of mouse and human islets damaged by cytokines was significantly improved by supplementation of EPL in the culture (p = 0.003 and <0.001 for mouse and human islets respectively). EPL significantly inhibited intracellular expression of IL‐1β and IL‐6 in cytokine‐damaged human islets (p < 0.001). The viability of human islets in hypoxic conditions was significantly better when treated with EPL (p < 0.001). In the in vivo mouse assay, the EPL‐treated islet group had a higher cure rate than the untreated control, with marginal statistical significance (75 and 17% respectively, p = 0.07).

Conclusions

EPL could be a potent agent to protect islets from inflammatory and hypoxic conditions after isolation procedures. Further studies to clarify the effect of EPL in islet transplantation are warranted. Copyright © 2015 John Wiley & Sons, Ltd.