bluuebunny/crossref_metadata_2025 huggingface dataset:
The Expansion Mechanism of the Cooperative Networks of Supply Support Organizations in a Public Health Emergency
Authors: Lian Chenxi , Wang Jian , Liu Jida
Published: August 2021

The outbreak of COVID-19 has significantly restricted the productive capacity of society and resulted in a shortage of supplies to maintain survival. Lightening the burden not only depends on government agencies, but also needs extensive social organization participation. However, few studies focus on how to promote social cooperation to support the provision of emergency supplies. This study aimed to find out the theoretical mechanism to expand the cooperative networks of supply support organizations during the epidemic. Data from the emergency response to the COVID-19 pandemic in China were used. Three cooperative networks from a progressive perspective were constructed based on the cooperative relationships among organizations. The expansion mechanism was verified by the exponential random graph model. The results show that when the institutional network expands into an interactive network, the composition of organization types has changed, but the cooperative network’s efficiency does not improve much. The matching effect of the organizational type and the Matthew effect of nodes are both effective paths to promote cooperative network expansion, however, the structure effect shows that complex relationship structure is not a critical factor. Our findings highlight the importance of core organizations and the function of different types of organizations in building cooperative network as well as providing theoretical frameworks for policymakers to use in guiding and motivating social cooperation in emergency supplies.
The Kurdish Women’s Movement in Turkey and Its Struggle for Gender Justice
Authors: Merdjanova Ina
Published: August 2021

This paper looks at the Kurdish women’s struggles for gender justice at the intersection of two diverse social movements in Turkey: the Kurdish national movement, on the one hand, and the Turkish feminist movement, on the other. It argues that the Kurdish Women’s Movement (KWM) has functioned as a powerful process of learning for both men and women in the Kurdish community and in the larger society. It has destabilized and transformed the feudal–patriarchal relations and norms in the Kurdish community, the lingering sexism in the Kurdish movement, and the majoritarian constraints in the Turkish feminist movement.
Impact of Income Inequality on Urban Air Quality: A Game Theoretical and Empirical Study in China
Authors: Wang Feng , Yang Jian , Shackman Joshua , Liu Xin
Published: August 2021

Income inequality and environmental pollution are of great concern in China. It is important to better understand whether the narrowing of income inequality and environmental improvement contradict each other. The study aims to investigate the linkage between income inequality and environmental pollution. To illustrate the interplay between different income groups on environmental issues, we apply a mixed-strategy game. Based on the game-theoretic analytical result, the probability of residents supporting clean energy and environmental protection decreases as income inequality widens and increases as inequality narrows. This empirical study is based on the proportion of coal consumption and urban air pollution data from 113 key environmental protection cities and regions in China. The air quality data are from the National Environmental Air Quality Monitoring Network published in the China Statistical Yearbook from 2014–2018. Convincing results show that regions with higher income inequality suffer severe smog and related pollution and that economies with narrow income disparity experience significant improvements in smog and pollution control, with the expansion of the proportion of clean energy use. The results also provide no evidence of the impact of per capita income on pollution. We studied the relationship between individuals of different wealth levels within an economy, within a repeated-game setting. The finding suggests that the distribution of growth impacts pollution. Imposing higher taxes on air polluters while transferring the revenue to the lower-income group is suggested.
Protective Factors That Foster Resilience to HIV/AIDS: Insights and Lived Experiences of Older Gay, Bisexual, and Other Men Who Have Sex with Men
Authors: Liboro Renato M. , Yates Tammy C. , Bell Sherry , Ranuschio Brandon , Da Silva George , Fehr Charles , Ibañez-Carrasco Francisco , Shuper Paul A.
Published: August 2021

Since the beginning of the HIV/AIDS epidemic, gay, bisexual, and other men who have sex with men (gbMSM) have been disproportionately impacted by HIV/AIDS health disparities. Research showed that resilience to HIV/AIDS is associated with increased use of relevant health services, lower sexual health risks, and improved mental health outcomes among racially and ethnically diverse gbMSM. As the subpopulation that has historically been impacted by HIV/AIDS the longest, older gbMSM living with HIV/AIDS have inarguably exhibited resilience to HIV/AIDS the most. The qualitative study described in this paper sought to identify and examine protective factors that fostered resilience to HIV/AIDS based on the insights and lived experiences of racially and ethnically diverse, older gbMSM. Applying a community-based participatory research approach that included the meaningful involvement of older gbMSM living with HIV/AIDS in different roles (i.e., advisory committee member, collaborator, peer researcher, and participant), the study recruited and included forty-one older gbMSM living with HIV/AIDS from Ontario, Canada, in confidential, semi-structured interviews. Utilizing thematic analysis, we identified three major themes from the participant interviews as factors that fostered the resilience of older gbMSM to HIV/AIDS and helped to address HIV/AIDS health disparities: (1) established protective factors, (2) behavioral protective factors, and (3) controversial protective factors. This paper argues for the importance of valuing and capitalizing on these protective factors in the conceptualization and development of interventions, services, and programs that are dedicated to fostering resilience to HIV/AIDS.
The Impact of COVID-19 Pandemic in Portuguese Cancer Patients: A Retrospective Study
Authors: Lima Aurea , Sousa Hugo , Nobre Amanda , Faria Ana Luisa , Machado Manuela
Published: August 2021

Literature reports that SARS-CoV-2 infection in cancer patients may be associated with higher severity and mortality, nevertheless the knowledge is limited. We aimed to describe patients’ demographic characteristics and COVID-19 disease outcomes in Portuguese cancer patients. We conducted a retrospective study in a cohort of cancer patients diagnosed with COVID-19. A total of 127 individuals were included: 46.5% males and 53.5% females, with a median age of 72 years. Clinicopathological characteristics were used in univariate and multivariable logistic regression analyses to estimate odds ratios for each variable with outcomes adjusting for potential confounders. Our cohort revealed that 84.3% of patients had more than one risk factor for severe disease rather than cancer. In total, 36.2% of patients were admitted to the Department of Internal Medicine, 14.2% developed severe disease, 1.6% required Intensive Care Unit, and mortality was observed in 11.8%. Severe COVID-19 disease was associated with unfit (ECOG PS > 2) patients (p = 0.009; OR = 6.39; 95% CI: 1.60–25.59), chronic kidney disease (p = 0.004; OR = 20.7; 95% CI: 2.64–162.8), immunosuppression (p < 0.001; OR = 10.3; 95% CI: 2.58–41.2), and presence of respiratory symptoms at diagnosis (p = 0.033; OR = 5.05; 95% CI: 1.14–22.4). Increased risk for mortality was associated with unfit patients (p = 0.036; OR = 4.22; 95% CI: 1.10–16.3), cardiac disease (p = 0.003; OR = 8.26; 95% CI: 2.03–33.6) and immunosuppression (p = 0.022; OR = 5.06; 95% CI: 1.27–20.18). Our results demonstrated that unfit and immunosuppressed patients, with chronic kidney disease and cardiac disease, have, respectively, an increased risk for severe disease and mortality related to COVID-19. Hence, this study provides important information on risk factors for severe COVID-19 disease and associated mortality in a Portuguese cancer population.
Music Therapy with Neonatal Intensive Care Unit-Discharged Mother-Infant Dyads: Developing a Method for Nurturing Communicative Parental Efficacy (CoPE with Music)
Authors: Calderon-Noy Galit , Gilboa Avi
Published: August 2021

While much advancement has been documented in the practice of music therapy in the neonatal intensive care unit (NICU) environment, there is currently a shortage of music therapy-based methods for NICU-discharged dyads. Back in their homes, mothers might feel alone, lacking guidance, and possibly losing their parental efficacy and their ability to communicate with their baby. In this article, we present a method for nurturing the communicative parental efficacy (CoPE) that was successfully practiced with several NICU-discharged dyads. In eight weekly sessions, the music therapist improvises with the dyad and focuses on (1) containing the mother’s emotions; (2) modeling musical interactions with the baby; and (3) practicing these musical interactions with the mother, enabling her to gain communicative parental efficacy. The basic ideas of CoPE are outlined, and a short case study is then described, to demonstrate how it is used. Finally, suggestions for future directions for the development of CoPE are provided.
Diaries of Nursing Students during the COVID-19 Pandemic: A Qualitative Descriptive Study
Authors: Türkleş Serpil , Boğahan Münevver , Altundal Hilal , Yaman Zeliha , Yılmaz Mualla
Published: August 2021

Little is known about the experiences of nursing students during the pandemic process. This research was conducted to determine the feelings, thoughts, and experiences of nursing students during the COVID-19 pandemic process. This qualitative study was conducted with 47 first-year nursing students of a faculty that experienced the COVID-19 pandemic between 3–30 April 2020. Student nurses stated that they felt fear and anxiety; they liked this situation in the beginning due to the constraints during the pandemic process, but due to the prolongation of this process, they experienced boredom due to monotonous extraordinary days of doing the same things every day and realized that every moment before the pandemic was very valuable. In addition, the students stated that rich and poor are equal in the face of the virus and that all humanity has learned solidarity by leaving wars, fights, and superiority efforts. In this process, it was found that nursing students have negative coping methods, such as not being able to manage time well due to constraints at home and spending too much time on the phone, internet, and computer. In this context, empowering nursing students to cope with challenging emotions and thoughts starting from their educational life will contribute to the development of both students and the profession.
Uganda Mountain Community Health System—Perspectives and Capacities towards Emerging Infectious Disease Surveillance
Authors: Siya Aggrey , Mafigiri Richardson , Migisha Richard , Kading Rebekah C.
Published: August 2021

In mountain communities like Sebei, Uganda, which are highly vulnerable to emerging and re-emerging infectious diseases, community-based surveillance plays an important role in the monitoring of public health hazards. In this survey, we explored capacities of village health teams (VHTs) in Sebei communities of Mount Elgon in undertaking surveillance tasks for emerging and re-emerging infectious diseases in the context of a changing climate. We used participatory epidemiology techniques to elucidate VHTs’ perceptions on climate change and public health and assessed their capacities to conduct surveillance for emerging and re-emerging infectious diseases. Overall, VHTs perceived climate change to be occurring with wider impacts on public health. However, they had inadequate capacities in collecting surveillance data. The VHTs lacked transport to navigate through their communities and had insufficient capacities in using mobile phones for sending alerts. They did not engage in reporting other hazards related to the environment, wildlife, and domestic livestock that would accelerate infectious disease outbreaks. Records were not maintained for disease surveillance activities and the abilities of VHTs to analyze data were also limited. However, VHTs had access to platforms that could enable them to disseminate public health information. The VHTs thus need to be retooled to conduct their work effectively and efficiently through equipping them with adequate logistics and knowledge on collecting, storing, analyzing, and relaying data, which will improve infectious disease response and mitigation efforts.
Do People Become More or Less Materialistic during Disasters? The Mediating Roles of Mortality Salience and Gratitude
Authors: Jiang Da , Liu Shuang , Lee John Chi-Kin , Li Liman Man Wai
Published: August 2021

Studies have yielded inconclusive findings regarding the relationship between disaster experience and materialism. Whereas some have found a positive relationship, others have reported a negative relationship. To clarify the mechanisms underlying these mixed findings, we proposed and examined two mechanisms, namely mortality salience and gratitude. A total of 214 participants (Mage = 42.05 years, SD = 16.49 years) were randomly assigned into either an experimental condition to experience a disaster or a control condition. Participants in the experimental condition reported a lower level of materialism than the scores of their counterparts in the control condition. Such effects were mediated by both mortality salience and gratitude. Participants in the experimental condition reported higher levels of both mortality salience and gratitude simultaneously. Mortality salience strengthened materialism, but gratitude weakened materialism. These findings highlighted the duel-existing mechanisms underlying the relationship between disaster experience and materialism.
Impact of Safety Culture on Safety Performance; Mediating Role of Psychosocial Hazard: An Integrated Modelling Approach
Authors: Naji Gehad Mohammed Ahmed , Isha Ahmad Shahrul Nizam , Mohyaldinn Mysara Eissa , Leka Stavroula , Saleem Muhammad Shoaib , Rahman Syed Mohamed Nasir Bin Syed Abd , Alzoraiki Mohammed
Published: August 2021

We conceptualize that safety culture (SC) has a positive impact on employee’s safety performance by reducing their psychosocial hazards. A higher level of safety culture environment reduces psychosocial hazards by improving employee’s performance toward safety concerns. The purpose of this study was to evaluate how psychosocial hazard mediates the relationship between safety culture and safety performance. Data were collected from 380 production employees in three states of Malaysia from the upstream oil and gas sector. Structural equation modeling was implemented to test the suggested hypotheses. The proposed model was evaluated using structural equation modeling. A stratified sampling with a Likert 5-point scale was used to distribute the questionnaires. Furthermore, the proposed model was tested using the simulation of the structural equation and partial. According to our findings, all hypotheses were significant. A review of prior studies was used to select the items of the dimension for the data collection. Safety culture was assessed with psychosocial hazard to determine its direct and indirect impact on safety performance. Results suggest that to enhance safety performance (leading and lagging), psychosocial concerns in the workplace environments should be taken into consideration by employees. In addition, the findings showed that the psychosocial hazard fully mediates the relationship between safety culture and safety performance.
Facilitators and Barriers for Young Medical Doctors Writing Their First Manuscript for Publication
Authors: Raffing Rie , Jensen Thor Bern , Larsen Sanne , Konge Lars , Møller Christine , Tønnesen Hanne
Published: August 2021

Although scientific publication is often mandatory in medical professions, writing the first research article for publication is challenging, especially as medical curricula have only a minor focus on scientific writing. The aim was therefore to identify facilitators and barriers experienced by medical doctors writing their first scientific article for publication. An explorative inductive approach made use of semi-structured interviews for collecting data until saturation. Data were analyzed with systematic text condensation. Several barriers were identified: (a) writing in general; (b) writing in English; (c) dealing with content, structure, and presentation; and (d) navigating in the author group. Good supervision in the initial writing phase was a facilitating factor. Medical doctors requested a course in which they could work on their own articles and give feedback to fellow students. They valued skilled lecturers and individual supervision, and they wanted to learn about author instructions, how to present text correctly, and how to sell their core message. Their goal was to create a useful end product and to obtain European Credit Transfer System (ECTS) points. The facilitators and barriers that medical doctors experience when writing their first scientific article for publication and their course requests should be reflected in the learning objectives and content of future courses.
Insomnia and Insomnia-Related Care in the Department of Veterans Affairs: An Electronic Health Record Analysis
Authors: Bramoweth Adam D. , Tighe Caitlan A. , Berlin Gregory S.
Published: August 2021

The objective was to examine insomnia and insomnia-related care within a regional network of Department of Veterans Affairs (VA) facilities since the VA roll-out of cognitive behavioral therapy for insomnia (CBT-I) in 2011. A retrospective analysis of VA electronic health records (EHR) data from 2011 to 2019 was conducted. The annual and overall prevalence of four insomnia indicators was measured: diagnoses, medications, consultations for assessment/treatment, and participation in CBT-I. Also examined were sociodemographic and clinical differences among veterans with and without an insomnia indicator, as well as differences among the four individual insomnia indicators. The sample included 439,887 veterans, with 17% identified by one of the four indicators; medications was most common (15%), followed by diagnoses (6%), consults (1.5%), and CBT-I (0.6%). Trends over time included increasing yearly rates for diagnoses, consults, and CBT-I, and decreasing rates for medications. Significant differences were identified between the sociodemographic and clinical variables across indicators. An evaluation of a large sample of veterans identified that prescription sleep medications remain the best way to identify veterans with insomnia. Furthermore, insomnia continues to be under-diagnosed, per VA EHR data, which may have implications for treatment consistent with clinical practice guidelines and may negatively impact veteran health.
The Significance of the DUF283 Domain for the Activity of Human Ribonuclease Dicer
Authors: Szczepanska Agnieszka , Wojnicka Marta , Kurzynska-Kokorniak Anna
Published: August 2021

Dicers are multidomain proteins, usually comprising an amino-terminal putative helicase domain, a DUF283 domain (domain of unknown function), a PAZ domain, two RNase III domains (RNase IIIa and RNase IIIb) and a dsRNA-binding domain. Dicer homologs play an important role in the biogenesis of small regulatory RNAs by cleaving single-stranded precursors adopting stem-loop structures (pre-miRNAs) and double-strand RNAs into short RNA duplexes containing functional microRNAs or small interfering RNAs, respectively. Growing evidence shows that apart from the canonical role, Dicer proteins can serve a number of other functions. For example, results of our previous studies showed that human Dicer (hDicer), presumably through its DUF283 domain, can facilitate hybridization between two complementary RNAs, thus, acting as a nucleic acid annealer. Here, to test this assumption, we prepared a hDicer deletion variant lacking the amino acid residues 625-752 corresponding to the DUF283 domain. The respective 128-amino acid fragment of hDicer was earlier demonstrated to accelerate base-pairing between two complementary RNAs in vitro. We show that the ΔDUF(625-752) hDicer variant loses the potential to facilitate RNA-RNA base pairing, which strongly proves our hypothesis about the importance of the DUF283 domain for the RNA-RNA annealing activity of hDicer. Interestingly, the in vitro biochemical characterization of the obtained deletion variant reveals that it displays different RNA cleavage properties depending on the pre-miRNA substrate.
TNFα and Immune Checkpoint Inhibition: Friend or Foe for Lung Cancer?
Authors: Benoot Thomas , Piccioni Elisa , De Ridder Kirsten , Goyvaerts Cleo
Published: August 2021

Tumor necrosis factor-alpha (TNFα) can bind two distinct receptors (TNFR1/2). The transmembrane form (tmTNFα) preferentially binds to TNFR2. Upon tmTNFα cleavage by the TNF-alpha-converting enzyme (TACE), its soluble (sTNFα) form is released with higher affinity for TNFR1. This assortment empowers TNFα with a plethora of opposing roles in the processes of tumor cell survival (and apoptosis) and anti-tumor immune stimulation (and suppression), in addition to angiogenesis and metastases. Its functions and biomarker potential to predict cancer progression and response to immunotherapy are reviewed here, with a focus on lung cancer. By mining existing sequencing data, we further demonstrate that the expression levels of TNF and TACE are significantly decreased in lung adenocarcinoma patients, while the TNFR1/TNFR2 balance are increased. We conclude that the biomarker potential of TNFα alone will most likely not provide conclusive findings, but that TACE could have a key role along with the delicate balance of sTNFα/tmTNFα as well as TNFR1/TNFR2, hence stressing the importance of more research into the potential of rationalized treatments that combine TNFα pathway modulators with immunotherapy for lung cancer patients.
Analysis of the Applicability of microRNAs in Peripheral Blood Leukocytes as Biomarkers of Sensitivity and Exposure to Fractionated Radiotherapy towards Breast Cancer
Authors: Marczyk Michal , Polańska Joanna , Wojcik Andrzej , Lundholm Lovisa
Published: August 2021

Biomarkers for predicting individual response to radiation and for dose verification are needed to improve radiotherapy. A biomarker should optimally show signal fidelity, meaning that its level is stable and proportional to the absorbed dose. miRNA levels in human blood serum were suggested as promising biomarkers. The aim of the present investigation was to test the miRNA biomarker in leukocytes of breast cancer patients undergoing external beam radiotherapy. Leukocytes were isolated from blood samples collected prior to exposure (control); on the day when a total dose of 2 Gy, 10 Gy, or 20 Gy was reached; and one month after therapy ended (46–50 Gy in total). RNA sequencing was performed and univariate analysis was used to analyse the effect of the radiation dose on the expression of single miRNAs. To check if combinations of miRNAs can predict absorbed dose, a multinomial logistic regression model was built using a training set from eight patients (representing 40 samples) and a validation set with samples from the remaining eight patients (15 samples). Finally, Broadside, an explorative interaction mining tool, was used to extract sets of interacting miRNAs. The most prominently increased miRNA was miR-744-5p, followed by miR-4461, miR-34a-5p, miR-6513-5p, miR-1246, and miR-454-3p. Decreased miRNAs were miR-3065-3p, miR-103a-2-5p, miR-30b-3p, and miR-5690. Generally, most miRNAs showed a relatively strong inter-individual variability and different temporal patterns over the course of radiotherapy. In conclusion, miR-744-5p shows promise as a stable miRNA marker, but most tested miRNAs displayed individual signal variability which, at least in this setting, may exclude them as sensitive biomarkers of radiation response.
Inhibition of BET Proteins during Adolescence Affects Prefrontal Cortical Development: Relevance to Schizophrenia
Authors: Bilecki Wiktor , Wawrzczak-Bargieła Agnieszka , Majcher-Maślanka Iwona , Chmelova Magdalena , Maćkowiak Marzena
Published: August 2021

Background: The present study investigated the role of proteins from the bromodomain and extra-terminal (BET) family in schizophrenia-like abnormalities in a neurodevelopmental model of schizophrenia induced by prenatal methylazoxymethanol (MAM) administration (MAM-E17). Methods: An inhibitor of BET proteins, JQ1, was administered during adolescence on postnatal days (P) 23–P29, and behavioural responses (sensorimotor gating, recognition memory) and prefrontal cortical (mPFC) function (long-term potentiation (LTP), molecular and proteomic analyses) studies were performed in adult males and females. Results: Deficits in sensorimotor gating and recognition memory were observed only in MAM-treated males. However, adolescent JQ1 treatment affected animals of both sexes in the control but not MAM-treated groups and reduced behavioural responses in both sexes. An electrophysiological study showed LTP impairments only in male MAM-treated animals, and JQ1 did not affect LTP in the mPFC. In contrast, MAM did not affect activity-dependent gene expression, but JQ1 altered gene expression in both sexes. A proteomic study revealed alterations in MAM-treated groups mainly in males, while JQ1 affected both sexes. Conclusions: MAM-induced schizophrenia-like abnormalities were observed only in males, while adolescent JQ1 treatment affected memory recognition and altered the molecular and proteomic landscape in the mPFC of both sexes. Thus, transient adolescent inhibition of the BET family might prompt permanent alterations in the mPFC.
Hyponatremia in Children and Adults with Prader–Willi Syndrome: A Survey Involving Seven Countries
Authors: Coupaye Muriel , Pellikaan Karlijn , Goldstone Anthony P. , Crinò Antonino , Grugni Graziano , Markovic Tania P. , Høybye Charlotte , Caixàs Assumpta , Mosbah Helena , De Graaff Laura C. G. , Tauber Maithé , Poitou Christine
Published: August 2021

In Prader–Willi syndrome (PWS), conditions that are associated with hyponatremia are common, such as excessive fluid intake (EFI), desmopressin use and syndrome of inappropriate antidiuretic hormone (SIADH) caused by psychotropic medication. However, the prevalence of hyponatremia in PWS has rarely been reported. Our aim was to describe the prevalence and severity of hyponatremia in PWS. In October 2020, we performed a retrospective study based on the medical records of a large cohort of children and adults with PWS from seven countries. Among 1326 patients (68% adults), 34 (2.6%) had at least one episode of mild or moderate hyponatremia (125 ≤ Na < 135 mmol/L). The causes of non-severe hyponatremia were often multi-factorial, including psychotropic medication in 32%, EFI in 24% and hyperglycemia in 12%. No obvious cause was found in 29%. Seven (0.5%) adults experienced severe hyponatremia (Na < 125 mmol/L). Among these, five recovered completely, but two died. The causes of severe hyponatremia were desmopressin treatment for nocturnal enuresis (n = 2), EFI (n = 2), adrenal insufficiency (n = 1), diuretic treatment (n = 1) and unknown (n = 1). In conclusion, severe hyponatremia was very rare but potentially fatal in PWS. Desmopressin treatment for nocturnal enuresis should be avoided. Enquiring about EFI and monitoring serum sodium should be included in the routine follow-ups of patients with PWS.
Liver Resection for Intrahepatic Cholangiocarcinoma—Single-Center Experience with 286 Patients Undergoing Surgical Exploration over a Thirteen Year Period
Authors: Lang Hauke , Baumgart Janine , Heinrich Stefan , Huber Tobias , Heuft Lisa-Katharina , Margies Rabea , Mittler Jens , Hahn Felix , Gerber Tiemo S. , Foerster Friedrich , Weinmann Arndt , Marquardt Jens U. , Kloeckner Roman , Straub Beate K. , Bartsch Fabian
Published: August 2021

Background: Intrahepatic cholangiocarcinoma (iCCA) accounts for about 10% of primary liver cancer. Surgery is the only potentially curative treatment. We report on our current series of 229 consecutive hepatic resections for iCCA, which is one of the largest Western single-center series published so far. Methods: Between January 2008 to December 2020, a total of 286 patients underwent 307 surgical explorations for intended liver resection of iCCA at our department. Data were analyzed with regard to (1) preoperative treatment of tumor, (2) operative details, (3) perioperative morbidity and mortality, (4) histopathology, (5) outcome measured by tumor recurrence, treatment of recurrence and survival and (6) prognostic factors for overall and disease-free survival. Results: the resectability rate was 74.6% (229/307). In total, 202 primary liver resections, 21 repeated, 5 re-repeated, and 1 re-re-repeated liver resections were performed. In primary liver resections there were 77% (155/202) major hepatectomies. In 39/202 (20%) of patients additional hepatic wedge resections and in 87/202 (43%) patients additional 119 other surgical procedures were performed next to hepatectomy. Surgical radicality in first liver resections was 166 R0-, 33 R1- and 1 R2-resection. Following the first liver resection, the calculated 1-, 3- and 5-year-survival is 80%, 39%, and 22% with a median survival of 25.8 months. Until the completion of data acquisition, tumors recurred in 123/202 (60.9%) patients after a median of 7.5 months (range 1–87.2 months) after resection. A multivariate cox regression revealed tumor size (p < 0.001), T stage (p < 0.001) and N stage (p = 0.003) as independent predictors for overall survival. N stage (p = 0.040), preoperative therapy (p = 0.005), T stage (p = 0.004), tumor size (p = 0.002) and M stage (p = 0.001) were independent predictors for recurrence-free survival. Conclusions: For complete surgical removal, often extended liver resection in combination with complex vascular or biliary reconstruction is required. However, despite aggressive surgery, tumor recurrence is frequent and long-term oncological results are poor. This indicated that surgery alone is unlikely to make great strides in improving prognosis of patients with iCCA, instead clearly suggesting that liver resection should be incorporated in multimodal treatment concepts.
Examining the Neurobiology of Non-Suicidal Self-Injury in Children and Adolescents: The Role of Reward Responsivity
Authors: Case Julia A. C. , Mattoni Matthew , Olino Thomas M.
Published: August 2021

Although prior work has shown heightened response to negative outcomes and reduced response to positive outcomes in youth with a history of non-suicidal self-injury (NSSI), little is known about the neural processes underlying these responses. Thus, this study examined associations between NSSI engagement and functional activation in specific regions of interest (ROIs) and whole-brain connectivity between striatal, frontal, and limbic region seeds during monetary and social reward tasks. To test for specificity of the influence of NSSI, analyses were conducted with and without depressive symptoms as a covariate. We found that NSSI was associated with decreased activation following monetary gains in all ROIs, even after controlling for depressive symptoms. Exploratory connectivity analyses found that NSSI was associated with differential connectivity between regions including the DS, vmPFC, insula, and parietal operculum cortex when controlling for depressive symptoms. Disrupted connectivity between these regions could suggest altered inhibitory control of emotions and pain processing in individuals with NSSI. Findings suggest dysfunctional reward processes in youth with NSSI, even very early in the course of the behavior.
Prevalence and Prognostic Value of Psychological Stress Events in Patients with First Myocardial Infarction—Long-Term Follow-Up Study
Authors: Jaensch Andrea , Schöttker Ben , Schmucker Roman , Koenig Wolfgang , Brenner Hermann , Rothenbacher Dietrich
Published: August 2021

While there is good evidence that symptoms of depression determine prognosis of patients with coronary heart disease (CHD), the role of psychological stress is less clear. We evaluated the prognostic value of stressful events in patients with initial myocardial infarction (MI) with respect to subsequent cardiovascular events. The KAROLA-study included patients with CHD who participated in an in-patient rehabilitation program. A total of 577 patients with initial MI were included and self-reported psychological stressful events before their MI was assessed by a structured questionnaire. Hazard ratios were used to evaluate the long-term association of stressful events with secondary cardiovascular events. Additionally, associations of stressful events with depression, anxiety and other cardiovascular risk factors were investigated. Unusual stress at work (26.5%) and sleep disorder (23.4%) were the most frequently reported stressful events that occurred in the last 4 weeks before MI. However, only death of a family member showed a statistically significant increase in risk for subsequent cardiovascular events (HR: 1.59; 95%-CI: 1.01–2.50) and this result was not corrected for multiple testing. Notably, we found higher symptom scores of anxiety and depression associated with all single stressful event items. In conclusion, we found no clear patterns that psychological stressful events before MI would increase the long-term risk of subsequent adverse CHD events directly. However, we saw increased symptom scores of anxiety and depression in persons with stressful events.
Electrochemical Skin Conductance Alterations during Spinal Cord Stimulation: An Experimental Study
Authors: Goudman Lisa , Vets Nieke , Jansen Julie , De Smedt Ann , Billot Maxime , Rigoard Philippe , Cordenier Ann , Engelborghs Sebastiaan , Scafoglieri Aldo , Moens Maarten
Published: August 2021

Despite the well-known clinical effects of spinal cord stimulation (SCS), the mechanisms of action have not yet been fully unraveled. The primary aim of this study was to measure whether electrochemical skin conductance, as a measure of peripheral sympathetic autonomic function, is altered by SCS. A second aim was to compare skin conductance levels of patients with failed back surgery syndrome (FBSS) with age- and sex-matched healthy controls. Twenty-three patients with FBSS treated with SCS participated in this study. Sudomotor function was measured with the SudoscanTM instrument on the hands and feet during SCS on and off states. Difference scores in skin conductance between patients and age- and sex-matched healthy controls were calculated. Normal sudomotor function at the painful lower limb was revealed for 61% of the patients when SCS was activated. Skin conductance levels were not altered between on and off states of SCS. Differences in scores between patients and healthy controls were significantly different from zero. This study showed that SCS does not influencing the sympathetic nervous system in patients with FBSS, as measured by skin conductance levels. Moreover, it suggested that there is no normalization of the functioning of the sympathetic nervous system, despite the effectiveness of SCS to reduce pain intensity.
Microwave Synthesis of MnO2-Lignin Composite Electrodes for Supercapacitors
Authors: Mehta Siddhi , Jha Swarn , Huang Dali , Arole Kailash , Liang Hong
Published: August 2021

The demand for energy storage devices made from biodegradable materials has increased significantly due to sustainability. Currently, such devices possess vital issues, such as high manufacturing costs and toxicity, low reliability, as well as poor electrochemical performance. In this research, microwave synthesis was conducted to fabricate a low-cost, high-performing, plant-based electroactive material. MnO2 microparticles fabricated via microwave irradiation were deposited on two plant-based materials as substrates made of Al/lignin and Al/AC/lignin. The quasi-solid-state supercapacitors were assembled using a polymeric gel electrolyte of PVA/H3PO4. Scanning electron microscopy was performed to examine the polydispersity, morphology, and porosity of the micro-MnO2 deposited materials. FTIR and UV-vis spectroscopy were performed to study the composition and verify deposition of micro-MnO2 on the lignin-based matrixes. Cyclic voltammetry (CV) was employed to study the polarization resistance of the system. The cyclic charge-discharge (CCD) and electrochemical impedance spectroscopy (EIS) were performed to observe cyclic performance and interfacial resistances. Electrochemical tests showed that after 700 cycles of charge-discharge, both the supercapacitors exhibited high capacitance retention above 90%. Compared to the existing technology, this method enables consistent material structurization with tunable properties due to the controlled heating time and exposure to radiation with minimal waste. This work provides an alternative approach to synthesize low-cost and scalable green composite electrodes for flexible supercapacitors.
Koji Molds for Japanese Soy Sauce Brewing: Characteristics and Key Enzymes
Authors: Ito Kotaro , Matsuyama Asahi
Published: August 2021

Soy sauce is a traditional Japanese condiment produced from the fermentation of soybeans, wheat, and salt by three types of microorganisms, namely koji molds, halophilic lactic acid bacteria, and salt-tolerant yeast. The delicate balance between taste, aroma, and color contributes to the characteristic delicious flavor imparted by soy sauce. In soy sauce brewing, protein and starch of the raw materials are hydrolyzed into amino acids and sugars by enzymes derived from koji molds. These enzymatically hydrolyzed products not only directly contribute to the taste but are further metabolized by lactic acid bacteria and yeasts to most of organic acids and aromatic compounds, resulting in its distinctive flavor and aroma. The color of the soy sauce is also due to the chemical reactions between amino acids and sugars during fermentation. Therefore, koji mold, which produces various enzymes for the breakdown of raw materials, is an essential microorganism in soy sauce production and plays an essential role in fermenting the ingredients. In this review, we describe the manufacturing process of Japanese soy sauce, the characteristics of koji molds that are suitable for soy sauce brewing, and the key enzymes produced by koji molds and their roles in the degradation of materials during soy sauce fermentation, focusing on the production of umami taste in soy sauce brewing.
Deon and Telos: How Journalisms Are Evolving Their Ethical Approaches
Authors: Lynch Jake Alexander
Published: August 2021

Survey evidence shows a deontological ethical ideology remains dominant in global journalism, underpinned by a cultural value of detachment. This article opens by considering the strain imposed on these precepts in US corporate media while covering the Trump White House—ultimately to breaking point with the defeated president’s campaign to overturn the result, attempting to co-opt news organisations in the process. Feedback loops of cause and effect have, in any case, been exposed in today’s extended media, making the involvement of journalism in stories—through influence on audience responses and source behaviours—impossible to overlook. At the same time, new journalisms are emerging and growing, which adhere instead to a teleological ethical ideology. They openly identify themselves with external goals, and appeal for funds from donors and supporters on that basis. The article then goes on to present original data from analysing statements of aims and purpose put out by 12 news organisations working in four of these new fields: Peace Journalism; Solutions Journalism; Engaged, or Participatory Journalism; and Investigative Journalism, respectively. These represent a growing edge in journalism, it is argued, since they are positioned to respond positively to the changed conditions brought about by political and technological forces, which were illustrated by the Trump crisis. The study points to the changes in institutional arrangements now needed, if the structural foundations for their survival and success are to be strengthened.
Benefits of Online Sources of Information in the Tourism Sector: The Key Role of Motivation to Co-Create
Authors: Garcia-Haro Maria Angeles , Martinez-Ruiz Maria Pilar , Martinez-Cañas Ricardo , Ruiz-Palomino Pablo
Published: August 2021

Online sources of information are a matter of special interest in tourism research. In particular, they are key elements in the formation of destination image. The purpose of this paper is to examine the relationship between online sources of information and destination image and to analyze the mediating role of motivation to co-create in that relationship. A research model was developed, and hypotheses were tested on data collected from 394 usable responses about the World Heritage city of Cuenca (Spain). The results show that online commercial sources have a direct positive impact on the conative, affective and cognitive dimensions of the tourist image, in this order. Additionally, this study supports the view that motivation to co-create mediates the relationship between online information sources and destination image. Finally, motivation to co-create was also found to have a positive and direct impact, in this order, on conative, cognitive and affective image. The main value of our research is that it underlines the essential influence of motivation to co-create in the relationship between online information sources and destination image. This study also provides a critical review of the existing literature by positing a conceptual theoretical framework that links three types of online sources of information (social media sources, online commercial sources and online non-commercial sources) and destination image.
Spatial Scale Mismatches in the EU Agri-Biodiversity Conservation Policy. The Case for a Shift to Landscape-Scale Design
Authors: Falco Francesca L. , Feitelson Eran , Dayan Tamar
Published: August 2021

Agriculture is a major driver of the ongoing biodiversity decline, demanding an urgent transition towards a system that reconciles productivity and profitability with nature conservation; however, where public policies promoting such transitions are in place, their design often poorly fits the relevant biogeophysical systems, decreasing the policies’ expected effectiveness. Spatial scale mismatches are a primary example in this regard. The literature reviewed in this paper, drawing from both ecology and policy studies, suggests to foster policy implementation at the landscape scale, where most functional ecological processes—and the delivery of related ecosystem services—occur on farmland. Two strategies are identified for coordinating policy implementation at the landscape scale: the promotion of farmers’ collective action and the partition of space on an ecologically sound basis through spatial planning. As the new European Union Common Agricultural Policy (CAP) post-2023 is currently being defined, we assess if and how the draft agri-biodiversity legislation includes any of the strategies above. We find no comprehensive uptake of the landscape-scale perspective at the EU level, thereby suggesting that a powerful tool to overcome the CAP underperformance on biodiversity is being overlooked.
Validation of Chemokine Biomarkers in Duchenne Muscular Dystrophy
Authors: Ogundele Michael , Zhang Jesslyn S. , Goswami Mansi V. , Barbieri Marissa L. , Dang Utkarsh J. , Novak James S. , Hoffman Eric P. , Nagaraju Kanneboyina ,   CINRG-DNHS Investigators, Hathout Yetrib
Published: August 2021

Duchenne muscular dystrophy (DMD) is a progressive muscle disease involving complex skeletal muscle pathogenesis. The pathogenesis is triggered by sarcolemma instability due to the lack of dystrophin protein expression, leading to Ca2+ influx, muscle fiber apoptosis, inflammation, muscle necrosis, and fibrosis. Our lab recently used two high-throughput multiplexing techniques (e.g., SomaScan® aptamer assay and tandem mass tag-(TMT) approach) and identified a series of serum protein biomarkers tied to different pathobiochemical pathways. In this study, we focused on validating the circulating levels of three proinflammatory chemokines (CCL2, CXCL10, and CCL18) that are believed to be involved in an early stage of muscle pathogenesis. We used highly specific and reproducible MSD ELISA assays and examined the association of these chemokines with DMD pathogenesis, age, disease severity, and response to glucocorticoid treatment. As expected, we confirmed that these three chemokines were significantly elevated in serum and muscle samples of DMD patients relative to age-matched healthy controls (p-value < 0.05, CCL18 was not significantly altered in muscle samples). These three chemokines were not significantly elevated in Becker muscular dystrophy (BMD) patients, a milder form of dystrophinopathy, when compared in a one-way ANOVA to a control group but remained significantly elevated in the age-matched DMD group (p < 0.05). CCL2 and CCL18 but not CXCL10 declined with age in DMD patients, whereas all three chemokines remained unchanged with age in BMD and controls. Only CCL2 showed significant association with time to climb four steps in the DMD group (r = 0.48, p = 0.038) and neared significant association with patients’ reported outcome in the BMD group (r = 0.39, p = 0.058). Furthermore, CCL2 was found to be elevated in a serum of the mdx mouse model of DMD, relative to wild-type mouse model. This study suggests that CCL2 might be a suitable candidate biomarker for follow-up studies to demonstrate its physiological significance and clinical utility in DMD.
Genetic Parameters for Different Measures of Feed Efficiency and Their Relationship to Production Traits in Three Purebred Pigs
Authors: Santiago Kier Gumangan , Lopez Bryan Irvine , Kim Sung-Hoon , Lee Dong-Hui , Cho Young-Gyu , Song Yu-Na , Seo Kang-Seok
Published: August 2021

Residual feed intake (RFI) gained attention as a potential alternative to the feed conversion ratio (FCR). Thus, this study aimed to estimate genetic parameters for different feed efficiency (FE) traits (FCR, RFI1 to RFI5) and their genetic correlation to on-test daily weight gain (ADG), backfat (BFT), loin muscle area (LMA), lean percentage (LP), and total feed intake (FI) for 603 Male Duroc (DD), 295 Landrace (LL), and 341 Yorkshire (YY). The common spatial pen effect was also estimated in these traits. Five RFI measures were estimated by regressing daily feed intake on initial testing age (ITA), initial testing weight (IBW), and ADG for RFI1; other models were the same as RFI1 except for additional BFT for RFI2; LMA for RFI3; BFT and LMA for RFI4; BFT, LMA, and average metabolic body weight (AMBW) instead of IBW for RFI5. Genetic parameters estimated using two animal models and the REML method showed moderate heritability for FCR in all breeds (0.22 and 0.28 for DD, 0.31 and 0.39 for LL, 0.17 and 0.22 for YY), low heritability for the majority of RFI measures in DD (0.15 to 0.23) and YY (0.14 to 0.20) and moderate heritability for all RFI measures in LL (0.31 to 0.34). Pen variance explained 7% to 22% for FE and 0% to 9% for production traits’ phenotypic variance. The genetic correlation revealed that selection against less complex RFI1 in DD and LL and RFI2 in YY would bring the most advantageous reduction to FI (0.71 for DD, 0.49 for LL, 0.43 YY) without affecting ADG in all breeds (0.06 for DD, −0.11 for LL, 0.05 for YY), decrease in BFT, and increase in LP in DD (0.51 in BFT, −0.77 in LP) and LL (0.45 in BFT, −0.83 in LP). Therefore, inclusion of these breed-specific RFI measures in the future selection criteria would help improve feed efficiency in the swine industry.