bluuebunny/crossref_metadata_2025 huggingface dataset:
Health-related Quality of Life Assessment in Patients with Malignant Gliomas
Authors: Taskiran Emine , Kemerdere Rahsan , Akgun Mehmet Y , Cetintas Semih C , Alizada Orkhan , Kacira Tibet , Tanriverdi Taner
Published: December 2021

Background:

High-grade gliomas have limited time of survival despite aggressive treatment. Patients experience a decline in their physical and mental capacities, affecting their quality of life (QoL), and require proper therapeutic strategies.

Objective:

To assess the QoL of malignant glioma patients before and after the treatment in a longitudinal study of six months.

Methods and Material:

Forty-nine patients who were pathologically diagnosed with glioblastoma and anaplastic glioma according to WHO 2016 were included in this prospective study. The assessment of quality of life was done using the European Organization for Research and Treatment of Cancer (EORTC) quality of life (QoL) questionnaire core-30 prior to surgery, 1 and 5 months after the operation.

Results:

The decline in Karnofsky scores of the patients was statistically significant. Among the symptom scales, fatigue was more prominent after surgery while pain was noticeable during chemotherapy which was correlated with increased age. The mean overall QoL scores showed a clinically significant decline during the postoperative period. The functional scores demonstrated a significant decline in between all periods. Sex was significantly correlated with preoperative emotional and physical functioning. The patients with right-sided lesions had higher mean scores for social and cognitive functioning.

Conclusions:

Low KPS, older age, and female gender may affect cancer symptoms and physical and social activities in malignant glioma patients. Cognitive functions as well as social and occupational roles gradually decline during the first six months of treatments. Overall QoL of high-grade glioma patients deteriorates especially after radiotherapy and during the first months of chemotherapy.
An Unusual Presentation of Progressive Supranuclear Palsy
Authors: Dec-Ćwiek Malgorzata , Boczarska-Jedynak Magdalena , Pera Joanna
Published: December 2021

Progressive supranuclear palsy (PSP) is a neurodegenerative disorder with varied manifestations. Progressive gait freezing (PGF) is considered to be a rare and uncommon presentation of PSP. Here we present 2 patients with freezing of gait as the initial manifestation of PSP-PGF. One patient fulfilled the criteria of PSP-PGF, while the second did not. Nevertheless, according to the movement disorders society-PSP criteria, he met the threshold for possible PSP with progressive gait freezing. We emphasize a broad PSP-PGF spectrum of symptoms and sensitize to the fact that freezing of backward gait could indeed represent an unusual manifestation of atypical parkinsonism.
Drug-resistant 'Non-Lesional' Visual Sensitive Epilepsies of Childhood – Electroclinical Phenotype–Genotype Associations
Authors: Menon Ramshekhar N , Nambiar Poornima N , Keni RR , Baishya Jitupam , Radhakrishnan Ashalatha , Cherian Ajith , Nampoothiri Sheela , Madhavilatha GK , Kotecha Udaya H , Thomas Sanjeev V
Published: December 2021

Background:

Sporadic nonlesional intractable visual-sensitive epilepsies of childhood represent a challenging subset of epilepsies in terms of management and prognostication given a propensity to evolve as epileptic encephalopathy.

Objective:

To study the genetic heterogeneity of drug-resistant visual sensitive epilepsy of childhood.

Methods:

A retrospective chart review was conducted on patients in the pediatric age group between 2016 and 2018, with drug-resistant epilepsy (DRE) and video electro encephalography (VEEG) documented reflex photosensitivity, eye-condition sensitivity. Those patients who underwent genetic testing with targeted next-generation sequencing using an epilepsy gene panel were selected.

Results:

During the study period, out of 96 patients who underwent genetic testing, 4 patients (4.17%) with sporadic DRE presented with clinical phenotypes ranging from myoclonic-atonic epilepsy, generalized epilepsy with eyelid myoclonia as well as febrile and unprovoked seizures, along with visual sensitivity. Video EEG documented abnormalities ranged from occipital, posterior-cortex and generalized discharges with “eyes-closed state” triggered, self-induced “smart-phone” triggered, photosensitive focal-onset and generalized myoclonic seizures. Accompanying developmental impairment was noted. These patients who were investigated with clinical exome sequencing were detected to have mutations in not only SCN1A genes (pathogenic exonic and intronic variants) but also CHD2 (pathogenic) and CACNA1H genes (a familial febrile-seizure susceptibility variant of unknown significance).

Conclusions:

The series highlights the complex genetics of drug-resistant visual-sensitive epilepsy of childhood. Such genotype–phenotype associations throw light on the role of ion-channel and non-ion channel genes on reflex epileptogenesis in this group of patients.
Steroid-Induced acute psychosis in an 8-year-old child with inflammatory bowel disease
Authors: Elbanoni Om-Elkhair , Altawaty Adel
Published: December 2021

We present a case of an 8-year-old male child diagnosed with Crohn's disease, and he experienced a steroid-induced psychosis during induction of remission with corticosteroid therapy. This study aims to report a steroid-induced psychosis in the pediatric age group and add this case to the limited number of reported pediatric patients who developed a steroid-induced psychosis with a focused review of the literature.
Vocal cord biopsy under local anesthesia, with flexible bronchoscope as an outpatient procedure, by “inside-out” technique
Authors: Ravi Ajay , Deshpande Anurag , Ramasubramaniam K , Aggarwal Manish , Goyal Rajiv
Published: December 2021

Background:

Pulmonologists commonly need to take biopsies of laryngeal lesions, either found incidentally while doing bronchoscopy for other indications or while investigating patients for hoarseness of voice and cough. Biopsy of laryngeal lesions has been conventionally done under general anesthesia to provide adequate samples and minimize risks and patient discomfort. Of late, these biopsies have been done as outpatient procedures, by flexible endoscopes, under local anesthesia. However, vocal cord biopsies are often challenging due to poor patient compliance. We have tested an innovative method, which we have called the “inside-out” method, to circumvent this problem.

Objectives:

We aimed to analyze the feasibility, yield, and the safety of the “inside-out” technique for taking vocal cord biopsies as an outpatient procedure in awake patients.

Material and Methods:

This was a prospective observational study. Data of 38 patients with vocal cord lesions in whom the above technique was employed were analyzed.

Results:

The procedure had a diagnostic yield of 78.9% with a sensitivity of 96.7% and a specificity of 100% for detecting malignancy or dysplasia. There were no major complications.

Conclusions:

The “inside-out” technique was found to be feasible and safe and with a high yield.
A debris flow deposit in Mammoth Cave: field characterization
Authors: Bosch Rachel , Ward Dylan , Bird Aaron , Sturmer Dan , Olson Rick
Published: December 2021

This work presents an analysis of a debris flow deposit below Earth’s surface in the Mammoth Cave System in Kentucky, USA, and is the first study to characterize an in-cave debris flow to this level of detail. The deposit, named Mt. Ararat by cavers, has a maximum thickness of 7 m, a head-to-tail length of 75 m, and a total volume of about 3400 m3, as determined by terrestrial LiDAR and electrical resistivity surveys. The deposit is chaotic, angular, matrix-supported, and roughly inversely graded, with grain sizes, quantified through various grain-size distribution measuring techniques, ranging from clay through boulders larger than 1 m. The clasts are predominantly Mississippian Big Clifty sandstone, which is allochthonous in this part of the cave. The angularity of the blocks in the deposit indicate that they had not experienced significant erosion; and therefore, are determined to have been transported only a relatively short distance over a short time. The deposit profile is compound in appearance with two heads. We thus interpret this as a debris flow deposit resulting from two distinct flow events, and present a chronology of events leading to the present-day Mt. Ararat in Mammoth Cave. The findings of this work will inform further studies of karst-related erosional events, sediment transport, and deposition at different scales in karst aquifers, as well as the ways in which surface and subsurface processes interact to contribute to karst landscape evolution.
Reprezentacije inštrumentalne ljudske glasbe v slovenskih zvočnih množičnih medijih v obdobju med svetovnima vojnama
Authors: Turk Teja
Published: December 2021

Prispevek predstavlja spremembe, ki jih je inštrumentalna ljudska glasba doživljala med svetovnima vojnama skozi razvoj novih zvočnih medijev – gramofonskih plošč z 78 o/min in radia. S predstavljanjem inštrumentalne ljudske glasbe v medijih, njeno popularizacijo in komercializacijo se je oblikovala splošno veljavna podoba t. i. slovenske inštrumentalne ljudske glasbe, ki je recipročno vplivala tudi na ustvarjanje ljudskih godcev.
Conocimiento sobre el muestreo en estudiantes chilenos al término de la educación escolar
Authors: Ruiz-Reyes Karen , Ruz Felipe , Molina-Portillo Elena , Contreras José M.
Published: December 2021

En la actualidad, las nociones de inferencia estadística se incorporan dentro de las orientaciones curriculares de diversos países, incluido Chile, donde se le atribuye gran importancia a la noción de muestra y a su selección (muestreo). Por ello, este artículo tiene por objetivo indagar qué comprenden los estudiantes chilenos que cursan su último año de escolaridad sobre los métodos de muestreo. Se analizan las respuestas de 148 estudiantes chilenos de último año de secundaria (grado 12, 17-18 años) a un ítem de respuesta abierta sobre la identificación del sesgo de un método de muestreo. Los resultados muestran que los escolares prefieren el método de muestreo estratificado frente a otros y tienen dificultades para reconocer sesgos en la selección de muestras concretas.
Medidas de tendencia central y dispersión miradas desde un deporte típico chileno y la modelación estadística
Authors: Ramos-Rodríguez Elisabeth , Alvarado-Garcés Natalia , Vásquez Patricia , Vergara Andrea
Published: December 2021

Este artículo presenta los resultados de una propuesta de aula que considera la modelación estadística para la enseñanza de las medidas de tendencia central y dispersión, a partir del contexto que provee un deporte típico chileno. Desde un enfoque de investigación basado en el diseño, se elabora una propuesta de aula implementada en estudiantes de 15 y 16 años. Su diseño promueve la modelación estadística, considerando el contexto de un deporte nacional chileno, la rayuela, que permite abordar un problema cultural de interés para los estudiantes. Para el análisis de su implementación se articuló y adaptó las fases de un ciclo de investigación estadística con las fases de un modelo asociado al proceso de modelación matemática. Los hallazgos de la implementación evidencian que los estudiantes lograron transitar exitosamente en las dos primeras fases del proceso de modelación, teniendo algunos de ellos más dificultad en las dos últimas fases. Este estudio permite evidenciar que aún es necesario continuar investigando en cómo la modelación de naturaleza estadística se inserta en el currículum matemático, y cómo estas pueden conjugarse, de modo de contar con criterios e indicadores claros para evaluar el desempeño de estudiantes en actividades que involucren análisis estadísticos en contexto.
Preguntas elaboradas por profesores para el estudio de gráficos estadísticos: Los niveles de lectura que se identifican en sus propuestas
Authors: Árevalo-Menases Fabiola , Manzanares Julio
Published: December 2021

Esta investigación de enfoque cualitativo expone los resultados de un estudio exploratorio cuyo objetivo fue mostrar el nivel de lectura de gráficos estadísticos presentes en las preguntas propuestas por docentes de Educación Matemática en Chile, ante gráficos que presentan datos de contextos contingentes en un periodo de tiempo afectado por la situación sanitaria por COVID-19 y datos que carecen de contexto. Los datos obtenidos fueron categorizados de acuerdo a los niveles de lectura de gráficos estadísticos, en donde observamos una tendencia a la elaboración de preguntas que abordan niveles básicos de lectura de gráficos estadísticos, analizando si estos tienen relación con la formación inicial de los profesores, su experiencia docente y si existe diferencia ante los gráficos presentados. Se hace relevante incorporar datos de temáticas contingentes en el estudio de gráficos estadísticos, pues promueven un nivel de lectura mayor de los datos, lo que reafirma la importancia que adquiere el contexto en el estudio estadístico, así como la necesidad de fortalecer el desarrollo profesional docente en torno a la alfabetización estadística, con el fin de formar ciudadanos críticos en una sociedad en constante cambio.
Interpretación y comprensión de gráficos estadísticos por profesores de Matemáticas en formación
Authors: Sánchez Acevedo Nicolás , Toro Barbieri Elizabeth , Araya Bastias Daniela
Published: December 2021

La importancia que tiene los gráficos estadísticos hoy en día es incuestionable dada la alta presencia en diversos medios para representar información. Con la intención de poder complementar investigación en el área, llevamos a cabo un trabajo de replicación con profesores de Matemática en formación. A partir de esto, se llevó a cabo un trabajo con 23 estudiantes de la una carrera de Pedagogía en Matemática, quienes cursan en su mayoría el 6to semestre de formación y explorar en la comprensión gráfica que estos presentan en una actividad sobre esperanza de vida. El estudio fue realizado bajo una metodología cualitativa, haciendo uso de la técnica de análisis de contenido. Dentro de los resultados más significativos, se logró evidenciar una alta clasificación en los niveles 0 de perspectiva personal que se explica en el presente estudio y, nivel 1, de lectura de datos; mostrándose en algunas interpretaciones errores de lectura. A partir de estos resultados, se hace necesario que las casas de estudio, puedan reformular las habilidades en estadística que desarrollen y profundicen aspectos conceptuales de estadística en la formación del profesorado y lograr promover una enseñanza de la estadística que implique una comprensión profunda de esta disciplina.
Quality Reporting of Mixed Methods Research in Tourism-Related Studies
Authors: Van Heerden CH
Published: December 2021

The aim of this study is to gain scientific insight into internationally-accepted criteria for quality reporting of mixed methods research (MMR). Articles published post-2012 in a particular journal, which referred to “mixed methods” and “tourism”, and reported that qualitative and quantitative data were collected, were drawn from Google Scholar and Scopus. The reporting quality of these studies was analysed according to the GRAMMS framework (Good Reporting of a Mixed Methods Study). Most of the articles in the data set did not report on all the elements embedded in GRAMMS. It must not be seen as a reflection of the quality of the MMR design itself, nor is the study flawed. It indicates gaps in the reporting of important MMR elements that could be addressed in future research. Exemplars were identified that could serve as case studies for researchers in terms of the quality of reporting on MMR. Editorial boards should adopt guidelines on how MMR could be presented in articles submitted to their journals. These guidelines could assist authors in preparing their articles to conform to international standards on the reporting of MMR studies. Peer reviewers should use the guidelines to judge the quality of reporting on MMR methodology in articles under review. This study could also serve as a future reference for researchers, postgraduate students and supervisors who aim to incorporate MMR in their research.
Image and Risk Perception of Mozambique as a Tourism Destination: A Segmentation Study
Authors: Abdula Mariamo Amade , Breda Zélia , Eusébio Celeste
Published: December 2021

Tourism has been recognised as one of the main industries in the world. It creates opportunities for developing tourism destinations; however, it also requires adaptation to new challenges in constant evolution. In this context, there is a continuous need to identify and explore new tourism markets, take advantage of emerging opportunities, and create products that offer innovative and differentiating tourism experiences. Mozambique is betting on the development of tourism as a factor of economic and territorial dynamism. This article aims to present a destination image-based segmentation study of potential visitors to Mozambique. A questionnaire was administered to a sample of 382 potential visitors to Mozambique. The application of a hierarchical cluster analysis based on the perceived destination image allowed the identification of three clusters: “nostalgic”, “destination lovers”, and “concerned”. The results highlight differences in terms of perceived risk and intentional behaviour among the clusters identified. The paper ends with important practical implications to improve the image of Mozambique as a tourism destination.
Traffic Congestion and Efficient Ways to Deal with It in Tbilisi, Georgia
Authors: Kacharava Nino
Published: December 2021

Traffic Congestion has become a new version of plague for urbanized areas. Massive breakthroughs in technology, increasing in production of motorized cars, global reduction in prices for automobiles and the rapid population growth in Tbilisi, Georgia has led to the urgence of complete rearrangement of transportation system in the city.

As a post-Soviet Union country, Georgia has had rudiments like “Marshrutkas” (privately owned minibuses) as a primary mode of transportation. Serious research and actions started in 2019 when sustainable urban mobility plan was introduced in Tbilisi; which favors public transport and pedestrians. In the course of this project one of the main avenues was converted into complete street model and hourly parking was introduced in the city centers. However, the problem regarding traffic jams still stands. This paper contributes to analyzing current situation in Tbilisi and suggesting suitable solutions. It will cover how reversible lanes, road pricing, signalized Intersections, reserved bus lanes and parking can be adapted to Tbilisi in order to reduce traffic jams.
Dalyan-İztuzu (Doğu Akdeniz) Sahilinde Mikroplastik Kirliliğinin Araştırılması
Authors: ZİLİFLİ Aytuğ , TUNCER Sezginer
Published: December 2021

Bu çalışmada, Dalyan- İztuzu sahili boyunca 2019 yılında Haziran ve Temmuz aylarında 14 istasyonda örnekleme yapılmıştır. Örnekler, su yüzeyinden (0-15 cm) 2 deniz mili/saat hızında ve 20 dakika süre ile çekilen Manta net ile alınmıştır. Mikroplastikler binöküler stereo mikroskop altında şekillerine, ebadına ve tiplerine göre ayrılmıştır. Çalışmanın sonucunda mikroplastik yoğunluğu ortalama 0,148 ± 0,07 partikül/m2 olarak belirlenmiştir. Bu çalışmadan elde edilen değerlerin Marmara ve özellikle Akdeniz bölgesinde yapılan çalışmalar ile karşılaştırıldığında çok daha düşük olduğu tespit edilmiştir.
The ANALISIS PERAMALAN PERMINTAAN PRODUK MINUMAN HERBAL DENGAN METODE ARIMA PADA CV. GENTONG MAS
Authors: Nurfadilah Nanda
Published: December 2021

CV. Gentong Mas terletak di Kampung Sadang Lebak, Situsari, Karangpawitan, Garut. CV. Gentong Mas merupakan salah satu perusahaan yang memproduksi minuman herbal, produknya dinamakan gentong mas dan guchie mas. Akan tetapi pada penelitian ini, yang akan diteliti hanya produk gentong mas saja. Permasalahan yang dihadapi perusahaan yaitu permintaan yang tidak stabil dan tidak adanya peramalan untuk periode kedepannya Hal ini dikarenakan CV Gentong Mas putus kontrak kerja sama dengan distributor tunggal PT. Oriya Khazanah Sejahtera. Penyebab putus kontrak tersebut dikarenakan terjadi permasalahan di PT Oriya Khazanah Sejahtera sendiri.  Pada penelitian ini metode yang digunakan yaitu Autoregressive Integrated Moving Average (ARIMA), Seasonal Autoregressive Integrated Moving Average (SARIMA) dan Holt-Winters sebagai pembanding. tiga Metode tersebut digunakan untuk mengetahui hasil peramalan mana yang terbaik untuk 1 tahun mendatang, terhitung sejak September 2020 hingga Agustus 2021. Hasil peramalan ini di lihat dari 2 aspek, yaitu Nilai MSE (Mean Squared Error) terkecil dan uji validasi. Berdasarkan hasil pengolahan data diketahui Nilai MSE terkecil yaitu metode Seasonal Autoregressive Integrated Moving Average (SARIMA) dengan nilai MSE sebesar 4,705,580. Akan tetapi ketika di uji validasi, hasil peramalan yang paling mendekati permintaan sebenarnya selama 4 periode (bulan) yaitu metode Autoregressive Integrated Moving Average (ARIMA).  Berdasarkan hasil pengolahan data peramalan menggunakan aplikasi minitab, perbandingan nilai MSE dan uji validasi hasil peramalan menunjukkan bahwa metode terbaik ialah metode arima. Karena hasil peramalannya mendekati hasil permintaan yang sebenarnya.
CRITICAL ANALYSIS OF NIDANA AND SAMPRAPTHI OF AMAVATA WITH SPECIAL REFERENCE TO AUTOIMMUNITY
Authors: P.M. Aswathy , S Nagaraj
Published: December 2021

The human body is a conglomeration of dosha, dhatu and mala. Even though doshas are having opposite gunas they do not harm the body when in equilibrium state and it maintains the integrity of dushyas. Ama is a unique concept in Ayurveda which can be considered as improperly digested food or accumulated metabolic waste which is not expelled out of the body has a tremendous capacity to vitiate the dosha, dhatu and mala and is capable of producing various diseases. Amavata is a disease entity where ama and vata plays important role in the samprapthi of disease and viruddha ahara and chesta are considered to be the main causative factors. Autoimmunity is the system of immune responses of an organism against its healthy cells and tissues. Any disease that results from such an aberrant immune response is termed an autoimmune disease.
Keywords: Amavata, Ama, virudhahara, cheshta, autoimmunity
PRELIMINARY PHARMACEUTICAL AND ANALYTICAL EVALUATION OF SHRINGYADI LEHA
Authors: Karishma Karishma , Usha Sharma , Yadevendra Yadav , Mitra Shuchi , Chand Sharma Khem
Published: December 2021

Aims: Shringyadi Leha has been prepared and studied for its Physico-chemical parameters. The adopted formula- tion is Shringyadi Leha based on Chakradatta. Shringyadi Leha has significant efficacy in pediatric disorders. Methods and Material: The present study provides details of the preparation of Shringyadi Leha, and methods employed in Physico-chemical parameters. Results: Physico-chemical observations revealed the specific characters of the preparation. The preliminary HPTLC study of the compound revealed the components, eight spots in short UV 254nm, 09 spots in 366nm and 10 spots in long UV 550nm. Conclusions: Evaluation of Shringyadi lehyam can be used as a reference standard for further quality control research for the manufacturing and processing of Shringyadi Leah.
Keywords: Shringyadi Leha, Pharmaceutical parameters and HPTLC.
A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFECT OF VRIKSHAMLA TWAK KASHAYA AND DASHAMOOLA KASHAYA IN UDAVARTHINI YONIVYAPAT
Authors: G Sahana , Digambar P Shivale , B.K Kavitha , Parvathy Manju
Published: December 2021

Menstruation is a physiological, natural event in the reproductive stage of the female. Due to a sedentary lifestyle and lack of self-care, stress, untimely food and other factors, many gynaecological problems occur and one of the most common among them is Dysmenorrhea. Painful menstruation is the most common cause which disturbs the mental state of the woman also affecting her day to day activities during the cycle. Pain is the Pratyatma Lak- shana of Vata vikruti mentioned in Ayurveda. Artava Nishkramana is the normal function of Apana vayu which moves in Pratiloma gati and obstructs the pathway of Artava. In our Classics, most of the gynaecological prob- lems are discussed under Yonivyapat. Udavartini Yonivyapat can be co-related and defined as painful menstrua- tion i.e. Dysmenorrhea. Considering the prevalence of dysmenorrhea in the present era, the trial drug Vrikshamlatwak kashaya which possess the properties such as Shoolprashamana and Vatahara was selected to evaluate its effect in the management of Udavartini yonivyapat. Objectives: To compare and evaluate the effect of Vriksham- la Twak kashaya and Dashamoola kashaya in Udavarthini yonivyapat w.r.s primary dysmenorrhea. Methodolo- gy: This research work was a randomized comparative clinical study of 40 patients suffering from symptoms of Udavartini Yonivyapat, who were randomly selected and categorized into 2 groups of 20 patients each. Group A was treated with Vrikshamla Twak kashaya and group B with Dashamoola Kashaya. Both Kashayas were given in Apanakaala (before food) with Sukhoshna Jala as Anupana. Duration of Treatment: 10 days (Starting 7days before the commencement of cycle till 3rd day of the menstrual cycle) for 3 consecutive cycles. Results and In- terpretation- Both the groups showed statistically significant results. Statistically, there was no significant differ- ence between the groups. Conclusion: Both Vrikshamla Twak kashaya and Dashamoola Kashaya had an equal effect in treating Udavartini Yonivyapat.
Keywords: Udavartini, Dysmenorrhea, Vrikshamla Twak Kashaya, Dashamoola kashaya.
COMPARATIVE CLINICAL STUDY OF SHUNTHYAADI SNEHA YOGA NASYA OVER KSHAVATHU ROGA W.S.R. TO ALLERGIC RHINITIS BASED ON SNEHA MEDIA
Authors: Aithal Shreeganesh , Kurle Laxmi. B.
Published: December 2021

Shunthyaadi Sneha Yoga which is a Sneha Kalpana developed with Ghrita and Taila Paka method containing ingredients which are Kshavathu hara and indicated specifically in Kshavathu Roga. In Ayurveda, Kshavathu is a symptom of many diseases and at the same time a separate disease entity. The literal meaning of Kshavathu is sneezing and is the main symptom of Allergic Rhinitis and both share similar etiological factors. Allergic rhinitis is an atopic disease characterised by symptoms of nasal congestion, clear rhinorrhea, sneezing, postnasal drip, and nasal pruritis.
It is an inflammatory disorder of the nasal mucosa induced by allergen exposure triggering IgE-
mediated inflammation. Around 20–30 % of the Indian population suffers from allergic rhinitis and that 15 % develop asthma. In the present study, an attempt has been made to compare the efficacy of Shunthyaadi Taila Nasya and Shunthyaadi Ghrita Nasya designed in two groups comprising fifteen patients each and analysed with parametric and non-parametric tests. Both the groups showed remarkable results in the management of Kshavathu.
Keywords: Kshavathu, Shunthyaadi Sneha Yoga, Shunthyaadi Taila, Shunthyaadi Ghrita, Nasya,
A STUDY ON SROTODUSHTI WITH SPECIAL REFERENCE TO ASSESSMENT OF SROTOSHTI LAKSHANA IN ARTAVAVAHA SROTAS THROUGH CLINICAL, BIOCHEMICAL AND RADIOLOGICAL FINDINGS’- SURVEY STUDY
Authors: Shivakumari Shivakumari , Chate Vasudev A , Shreevastha Shreevastha
Published: December 2021

The concept of Srotas and Srotodushti Lakshana has been very scientifically explained in the various context of Ayurveda literature. Detailed Srotas and Srotodushti Lakshana are according to Charaka Samhita Vimansthana assessment of Srotodushti Lakshana can be done by Pratyksha Pramana and in detail explanation. The Srotas play an important role in physiology and the pathogenesis of diseases in normal state; they regulate the physiolo- gy of the body and maintain the anatomical structures of dhatus. The influences of aetiology factors on Srotas can affect pathological manifestations. Considering this fact present study explores various aspects related to the Sro- tas, Srotodushti and Srotodushti Lakshana. Objectives-To assessment of Srotodushti Lakshana in Artavavaha Srotas through Clinical, biochemical, and radiological examination in Artavavaha Srotas. Methodology -The study was conducted under two headings, conceptual and survey study. Conceptual study all the concerned litera- ture were referred and analysed and for survey study, the Artvavaha Sroto Vikara observed and survey through face-face interview. -Hence it is concluded that the knowledge of Srotas is not only used in learning about the anatomy of the transport system of the body but also to understand their physiology and pathology. It can be as- sessed through clinical, biochemical, and radiological findings.
Keywords: Srotas, Srotodushti Lakshana, Artavavaha Srotas,
A CLINICAL STUDY TO EVALUATE THE EFFICACY OF BILVA TAILA ANUVASAN BASTI IN VATAJA PRAVAHIKA
Authors: Kumari Parvesh , Kulkarni Satyajit P. , Vashist Priyanka
Published: December 2021

In the 21st century due to sedentary lifestyle, irregular food habits like in taking of unwholesome food Virudhha quantity, quality and timings, one is always under tremendous mental stress this leads to gastric upset (Agniman- dya) which is said to be the root cause of various diseases like Grahani, Atisara and Pravahika. Pravahika is a disease characterized by straining in the process of passage of stool which is mainly by vitiated Vayu hence Vata- ja Pravahika is selected for our study and has a correlation with signs and symptoms of Amoebiasis which is a type of Dysentery. Aim: To evaluate the efficacy of Bilva Taila Anuvasan Basti and also to compare the efficacy of Bilva Taila Anuvasan Basti and Laghu Gangadhar Choorna in the management of Vataja Pravahika. Materi- als and Methods: It was an open randomized trial study, and the current study was planned for 60 patients of Vataja Pravahika. Thirty patients (Group A) were treated with Anuvasan Basti along with Laghu Gangadhar Choorna and in other Thirty (Group B) were treated with Laghu Gangadhar Choorna only. Results and Conclu- sion: Individually both groups have given relief in cardinal signs and symptoms of Vataja Pravahika. Whilecomparing, it was statistically proved that Bilva Taila Anuvasan Basti (Group A) is more effective than Laghu Gangadhar Choorna (Group B) which shows the role /importance of Anuvasan Basti in the management of Vata- ja Pravahika.
Keywords: Vataja Pravahika, Amoebiasis, Bilva Taila Anuvasan Basti, Laghu Gangadhar Choorna
COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY OF GEETAM AND CHANDRANULOMAVILOMA PRANAYAMA IN KRODHA
Authors: T V Anagha , Rai Anil Kumar , Hegde Raviprasad
Published: December 2021

Krodha is a Manasika Vikara which can be assessed by Droha done by another person. Here is an attempt made to evaluate the efficacy of Geetam and Chandra Anuloma Viloma Pranayama in the management of Krodha. Forty subjects fulfilling the diagnostic and inclusion criteria were selected and randomly assigned into two groups. Group A was treated with Geetam, and Group B were treated with Chandra Anuloma Viloma Pranayama. The effect of treatment was assessed based on symptoms of Krodha, Intermittent explosive disorder and Buss and Perry Scale. Both Geetam and Chandra Anuloma Viloma Pranayama showed a statistically significant effect on the assessment criteria. On comparison between two groups, there is no statistically significant difference between Group A and Group B. Thus, the null hypothesis is rejected, and the alternative hypothesis (H1) is accepted i.e., There is an equivalent effect of both Geetam and Chandra Anuloma Viloma pranayama in the management of the Krodha.
Keywords: Geetam; Chandra Anuloma Viloma, Pranayama; Krodha; Aggression; Intermittent explosive disorder.
A VIEW OF AYURVEDA ON AUTISM SPECTRUM DISORDERS - A CONCEPTUAL STUDY
Authors: A K Nithya , Chowta Jithesh
Published: December 2021

Autism Spectrum Disorders (ASD) is a neuro-developmental disorder. It is defined by deficits in social reciproci- ty and communication and by unusual restricted, repetitive behavior1 It is one of the challenging disorders for children and their families. Prevalence estimates for autism spectrum disorder (ASD) have been increasing over the past few decades, with estimates at about 5 in10,000 in the 1960s and current estimates as high as 1 in 88.2 It is one of the challenging disorders for children and their families and this condition typically persists throughout one’s life period. While coming to the view from Ayurveda, most clinical features of different varieties of autism spectrum disorder resemble the features of Unmada. The condition may be due to the result of Khavaigunya of Srotas which nurtures Manas as a consequence of many Agantuja and Sahaja factors.3
Keywords: Autism Spectrum Disorders, Unmada, Manovaha srotas, Jnanotpatti
A COMPARATIVE CLINICAL STUDY TO EVALUATE THE EFFICACY
OF RAJAPRAVARTAKA CHURNA AND HINGUVACHADI CHURNA IN PCOS
Authors: Attar Shabeena. I. , Digamber Shivale.
Published: December 2021

Polycystic Ovarian Syndrome (PCOS) is the most common health problem caused by a disproportion of reproduc- tive hormones with the ovarian expression of various metabolic disorders and a wide range of clinical features such as obesity, menstrual abnormalities and hyperandrogenism. In this modern era, the erratic lifestyle, high- calorie diet and deskbound jobs have resultantly expanded the spread of hormonal disparities and menstrual disor- ders have led to an increased prevalence of PCOS up to 20-30 %. There are similar conditions explained in the classics under the context of Pushpaghni jataharini. The treatment should be Kapha-Vata hara, vatanulomana, dipana, pittavardhaka along with avoidance of causative factors. Considering the above facts, Rajapravartaka churna and Hinguvachadi churna were selected for the study. The present study was aimed to bring out the effect of Ayurveda in PCOS, which is safe and non-hormonal. Objectives of the study: 1) A comprehensive study of PCOS and its congruence in Ayurveda. 2) To study the efficacy of Rajapravartaka churna and Hinguvachadi churna in PCOS and to compare its efficacy. Materials and Methods: A randomized comparative clinical study of two groups, consisting of 20 patients in each group. Group A - Rajapravartaka churna orally in the dose of 3gm twice daily along with tila kwata as an anupana 50ml; before food for a period of two consecutive cycles. Group B was given Hinguvachadi churna orally in the dose of 250mg twice daily along with water; before food for a period of two consecutive cycles. Results and Interpretation: The study has shown a statistically signifi- cant difference between each group in its efficacy. Conclusion: Rajapravartaka churna showed better results thanHinguvachadi churna while taking the account of the percentage of each criterion.
Keywords: Polycystic ovarian syndrome, Pushpaghni Jataharini, Rajapravartaka Churna, Hinguvachadi
Churna.
CHITTA PARIKARMA OF YOGA DARSHANA AND ITS APPLICATION IN THE AYURVEDA
Authors: Nimbal Ashwini A. , Katti Anand , Kulkarni Akshar
Published: December 2021

Patanjali’s Yoga Darshana deals with the Chitta Parikarma as certain sublime attitudes to imbibe and to incul- cate in life. The Parikarmas are described as Maitri, Karuna, Harsha, Upeksha with Sukhi, Dukhi, Punyatma, Papatma respectively. These are four elements of true love and are the four immeasurable virtues, helps to calm the mind in a troubled and complicated world. Ayurveda is the science of life aimed at developing the physical, mental, intellectual, emotional, and spiritual levels of the human being and it states that health is the root cause for the attainment of Dharma, Artha, Kama and Moksha. Both Ayurveda and Yoga Darshana consider Moksha as the highest goal of life as both Ayurveda and Yoga Darshana has been evolved from the same source, the Veda. Both are practical and applied sciences and are said to be contemporary, the Yoga chiefly deals with the removal of psychological Vedanas and attainment of salvation, while Ayurveda is more concerned with physical and mental ailments. To achieve the goals of both Yoga Darshana and Ayurveda, the Chitta Parkarmas of Yoga Darshanaplays a very important role as these are the ways to keep the mind happy and calm hence the Ayurveda explained these Chitta Parikarmas under Sadvritta and while explaining the qualities of a physician.
Keywords: Yoga Darshana, Chitta Parikarma, Vaidya Vrutti, Ayurveda
AN INSIGHT OF IMPORTANCE OF DEEPANA & PAACHANA IN PANCHAKARMA: CONCEPTUAL STUDY
Authors: Yadav Ajay Kumar , Thakar Anup B
Published: December 2021

Panchakarma therapy is a unique clinical treatment done for bio-purification of the body. Both Shodhana (bio- purification) and Shamana treatment (Pacification Treatment) modalities of Ayurveda place equal emphasis on Deepana and Paachana (appetizer-digestives). Deepana and Paachana karma plays important role in bringing the Sama dosha (dosha associated with ama) to Nirama (doshas without ama) state, as they mobilize the doshas from Shakha to koshtha and thus helps in easy expulsion of Doshas from the body. Deepana and Paachana Karma, as Purvakarma of Shodhana (bio-purification) procedures, are also essential. Purvakarma (preoperative procedure) refers to the body's preparation for Panchakarma procedures, and the body needs to achieve the full benefits of the treatments. Shodhana without Ama- Paachana results in further complications. As a result, the treatment is based on Srotoshodhana, Paachana, Agnideepana, and Vatanulomana. Objective: The objective is to extensively ex- plore the concept of Deepana & Paachana and elicit its applied aspect in Panchakarma therapy. Data Source: All the available information related to Deepana & Paachana is mentioned in classical texts primarily in Charaka Samhita and its related Commentaries, articles, Journals. Review Methods: The information related to Deepana & Paachana and its judicious use in Panchakarma are reviewed by comparing and analysing the different aspects of both classical tests and allied commentaries as well as contemporary authors. Conclusion: The concept of Deepana & Paachana here has been studied analytically in the radiance of proper and judicious Panchakarma practices to elicit its utility in better treatment.
Keywords: Deepana, Paachana, Panchakarma, Purvakarma.
PREVENTIVE AND THERAPEUTIC EFFECT OF YOGĀSANA AND PRĀNĀYAM IN THE PATIENTS OF DIABETES MELLITUS: AN OVERVIEW
Authors: Kathait Rashmi , Pandey Ajai Kumar
Published: December 2021

Objective: The present review was carried out with the objectives of identifying the role of Yogāsana (yogic practices) and Prānāyam (breathing practices) as a modality to prevent and treat diabetes. Data Source: The fea- sible beneficial effects of Yogāsana (yogic practices) and Prānāyam (breathing practices) on diabetes were as- sessed, which is based on relevant classical texts along with textbooks of contemporary medical sciences. Be- sides, recent research articles related to clinical studies conducted in various institutions as available on the inter- net and published in authentic databases (Pub-Med, Google Scholar, Web of Science etc.) were also referred through the ancestry approach. Review Methods: The possible correlation has been made between collected in- formation and has been presented systematically. The quality of the studies was assessed by the author and logi- cally presented in this context. Result and Discussion: Yoga offers a non-invasive way to manage various clini- cal conditions up to some extent. It can be prescribed with other systems of medicines as an adjuvant for health promotion. Recent evidence suggests that Yoga and controlled lifestyle measures reduce blood sugar load in peo- ple with diabetes.
Keywords: Yoga, Yogāsana, Prānāyam, Diabetes mellitus, Insulin resistance, lifestyle disease.
CORRELATION BETWEEN PRAKRITI AND RITUCHARYA: A CONCEPTUAL STUDY
Authors: Savita Savita , Sharma Ashok Kumar
Published: December 2021

Ayurveda is the science of life, or the knowledge of living, which addresses all of the aspects of life that make it worthwhile to live in its purest form. The concept of Tridosha and Prakriti is central to Ayurveda's philosophy. Prakriti describes an individual's physical, physiological, and psychological expression. The unique biological constitution generated by the preponderance of the Tridoshas Vata, Pitta, and Kapha is known as human Prakriti. Such characteristics are inherited and remain with a person throughout his or her life. Prakriti is a person's constitution, which is unique to them and is regulated by their physiology. Individuals with Vata Prakriti have Alpa Bala and Alpa Ayu and are more susceptible to illnesses. Pitta Prakriti people have Madhyama Bala and Madhyama Ayu and are moderately prone to diseases, whereas Kapha Prakriti people have Uttama Bala and Uttama Ayu and are moderately prone to diseases. Prakriti, Vikara, Kala, and Bala are all linked to sustaining human health and producing sickness. Different illnesses result when Doshas rise or decrease in a person during specific seasons. Adana Kala and Visarga Kala are the two divisions of Kala. The debilitating phase is known as Adana Kala. The sun depletes one's physical power. The moon is powerful in Visarga Kala, and it provides strength to the living organism. These changes in the environment cause changes in the body's Dosha sthiti. Ritucharya (seasonal lifestyle) is recommended by Ayurveda for preventing illnesses caused by changes in Tridosha owing to Kala (season). In this study, we attempted to promote Ritucharya about Prakriti.
Keywords: Ayurveda, Ritucharya, Prakriti, Tridosha, Ritu
A CONCEPTUAL REVIEW OF HARATALA - AN ARSENIC-BASED AYURVEDIC COM- POUND
Authors: Chandra Sharad , Singh Karbhal Kamleshwar , Alka Bhagat
Published: December 2021

Objectives - Ayurveda is the science of life practised by ancient Aryans which is based on Atharva-Veda. The object of Ayurveda is to counteract the imbalance of three very essential elements, Vata, Pitta, and Kapha. Rasa Shastra is the branch of Ayurveda which deals with knowledge of alchemical & pharmaceutical processes. Haratala is an important mineral drug in Rasa Shastra for alchemical purposes and therapeutic uses. Methods – This review is focused on the concise discussion, collection and interpretation of Haratala related descriptions in different Ayur- vedic and modern literature. Results - Haratala is being used in the field of treatment of various diseases, especially in Rasa Shastra. There is no controversial opinion regarding the identity of 'Haratala' as it is equated with the 'Orpiment'(Arsenic Trisulphide) of modern mineralogy. Conclusions -Haratala is an Arsenic based Ayurvedic com- pound which is being used for several years in Ayurveda for treatment of various disease, especially in Vata- Kaphatmaka Vyadhi.
Keywords: Ayurveda, Rasa Shastra, Haratala, Arsenic-Trisulphide,
MANAGEMENT OF THROMBOANGIITIS OBLITERANS - A CASE REPORT
Authors: Chougule Vishal , Shetty Shailesh
Published: December 2021

Thromboangitis obliterans (TAOs) is a rare disease affecting arteries and veins of the upper and lower limbs. The condition has a strong association with the use of tobacco. Thromboangitis obliterans also known as Buerger's disease is found in the age group between 40 to 45 years, and men are most prone to get affected. The present case is a male aged 65 years complaining of a wound on the heel on the right foot, associated with pain, discharge, slough, foul smell, edema and discolouration of the skin for which he visited our hospital, the patient was previ- ously diagnosed as TAO, considering his clinical features at the time of admission, an intervention was planned based on the treatment principle of Dusta Vrana like Virechana, Basti and Raktamokshana. There was complete
healing of the wound at the end of the treatment with no signs of recurrence during the follow-up suggesting the need for Shodhana in the effective management of TAO.
Keywords: Dushta Vrana, Thromboangiitis Obliterans, Ayurveda, Panchakarma, Shodhana, Case report
REVIEW OF CHARAKOKTA SUTIKA PARICHARYA AND ITS CLINICAL SIGNIFICANCE
Authors: Gurjar Komal , Pushpalatha B. , Bharathi K. , Choudhary Poonam
Published: December 2021

The transformation of a female, from a woman to a mother is the happiest lifetime event, but this happiness is gained only after undergoing tremendous physical exertion during labour. The women become extremely debili- tated physically & mentally, after the delivery & there are more incidences of backache, feeling weakness etc. After the delivery of the baby, the placenta is expelled then the woman is termed as Sutika & the care is termed as Sutika-Paricharya. Mithyaachara during this period results in incurable diseases or diseases which are difficult to cure. After following proper Sutikopacharya (puerperal regimen) woman regains all the lost things and reaches pre-pregnancy status. The mode of Paricharya includes important therapies, nutritional diet &Swasthavrithapalana. The main achievements through Sutika-Paricharya are Garbhashayashuddhi, Dhatu- Paripurnata, Sthanya- Vriddhi,Punarnavekarana. So, the present study has been selected to review Charakokta- Sutika-Paricharya& its clinical importance.
Keywords: Sutika, SutikaParicharya, SutikaParicharya, Mithyaachara
PATHOGENESIS AND MANAGEMENT OF COVID-19 FROM THE PERSPECTIVE OF AYURVEDA
Authors: Reetika Pathak , S. R. Inchulkar , Sangeeta Bhagat
Published: December 2021

Today the whole world is going through an epidemic, which has been declared as a Corona pandemic. From vil- lage to city, from country to abroad, from elders to children, from illiterate to scientist, no one is untouched by its wrath. It is spreading from person to person through infection. The whole world is fighting this Corona virus and is engaged in getting rid of it. The entire medical system of the world, the medical community and other public sectors are playing their role as Covid-Warriors. Inhalation of infectious aerosols and close contact are the main routes of Covid-19 transmission. Proper prevention & management to stop or slow the spread of a contagious dis- ease. Ayurveda is also engaged in treating it with its original purpose. Ayurveda is a science of life, which deals with comfort and discomfort physiological and pathological aspects of life. The first principle of Ayurveda is to protect the health of the healthy, in which Ayurveda proclaims the ethics, it paves the way for a healthy lifestyle while eradicating diseases its second principle, in which Ayurveda describes its medical principles. Following a routine with a balanced diet is extremely important during the Corona period. A healthy diet & lifestyle is very important before, during & after an infection. People should resort to Panchkarma therapy and also to rejuvena- tion therapy with medicines that increase the strength of the body. Yoga helps a significant role in the psycho- social care and rehabilitation of Covid-19 in quarantine and isolation.
Keywords: Ayurveda, Covid-19, Health, Panchakarma, Yoga.