bluuebunny/crossref_metadata_2025 huggingface dataset:
North Carolina Academic Health Centers and Social Determinants of Health
Authors: Caruana Marc , Weinberger Morris , Shea Christopher M.
Published: November 2024

Background

Academic health centers (AHCs) have traditionally focused on 3 core missions: patient care, research, and education. The current changing health care environment requires AHCs to broaden their focus to improve the health of their communities. This study reports the opportunities and challenges for the 5 North Carolina AHCs addressing social determinants of health (SDOH).

Methods

We used a mixed methods design. We analyzed financial data from systemwide community benefits reports and the Form 990 Schedule H of the primary medical centers (when available) from the 5 AHCs, and we conducted 4 key informant (KI) interviews at each of the 5 AHCs for a total of 20 interviews.

Results

Overall, AHCs spend a very small percentage of their total spending on community improvement services and community benefit operations. By far, the largest amount spent on community benefit is for treating patients eligible for charity care. Food insecurity and access to health care were the most addressed SDOH. Housing was viewed as a crisis that needed to be addressed at statewide and national levels.

Limitations

Community benefits reports from North Carolina AHCs lack important details. Key informant interviews provide far more recent information on the quantity and breadth of initiatives than the latest community benefits reports that were all completed pre-pandemic. We only interviewed 4 stakeholders from each AHC in North Carolina.

Conclusion

A new strategic vision must incorporate social accountability into the AHCs’ core missions to remove barriers and institute and sustain change, but the AHCs face a steep challenge to incorporate social accountability at a core mission level.
Teledentistry as a Tool for Health Care Transformation
Authors: Kanan Christine , McLeod Caroline , Mathews Rebekah
Published: November 2024

Teledentistry is a valuable technology tool that supports dental professionals in improving access to oral health care. Technological infrastructure, workforce availability, staff readiness, reimbursement, and patient population served must all be considered when implementing teledentistry.
Cultural Attunement: A Critical Social Driver of Oral Health
Authors: Burgess-Flowers Jamie , Yokovich Kelsey
Published: November 2024

This perspective piece focuses on the impact that cultural influences have on oral health and underscores the need for culturally attuned care. It explores how integrating cultural elements into patient care can enhance health outcomes and offers a spectrum of recommendations for incorporating culturally attuned practices at various levels.
How North Carolina’s New Center on the Workforce for Health Can Contribute to Oral Health Improvements
Authors: MacCracken Andy
Published: November 2024

The recently created North Carolina Center on the Workforce for Health can help to ensure an adequate oral health workforce to appropriately meet the dental care needs of all our state’s residents.
II. BAYEZİD’İN OĞLU ŞEHZADE ABDULLAH’IN AİLESİ VE SANCAKBEYLİĞİ
Authors: Şafakcı Hamit
Published: November 2024

Tarih alanıyla ilgili çalışmalarda genel olarak hükümdar olan kişiler ayrıntılı incelenmiştir. Hükümdar olma ihtimali olan şehzadeler ise sadece ismen zikredilmiştir. Dönemin iyi anlaşılması için şehzadelerin hayatı da incelenmelidir. Buradan hareketle bir şehzadenin hayatından hareketle hangi bilgilere ulaşılabileceğini tespit etmek amaçlanmıştır. Osmanlı hükümdarı II. Bayezid’in en büyük oğlu olan Abdullah, 1461 yılında doğmuş ve 1483 yılında vefat etmiştir. Şehzade Manisa, Trabzon ve Konya’da görev yapmıştır. İlk olarak 1467 yılında Manisa’da görev yapmaya başlayan Şehzade Abdullah, son olarak Şehzade Cem sorunu üzerine Konya’ya görevlendirilmiştir. Sancak değişikliğinde bölgenin önemi ve şehzadenin tecrübesi gibi konular etkili olmuştur. Kaynaklarda şehzade hakkında dönem anlatımı içerisinde genel bilgiler verilmiştir. Bu çalışmada ise şehzadenin ailesi, çevresi, sancaklardaki görevleri ve ölümü üzerinde durulmuştur. Annesine, babasına ve şehzadeye ait vakıflara konu bağlamında değinilmiştir. Dolayısıyla Şehzade Abdullah’ın hayatı ayrıntılı olarak incelenmiştir. Makale hazırlanırken kroniklerden, arşiv malzemelerinden ve modern çalışmalardan istifade edilmiştir. Çalışmada açıklığa kavuşmayan noktalar olsa da bazı sorunların çözülmesinde bir şehzadenin hayatının incelenmesi faydalı olmuştur.
TRABZON AHKÂM DEFTERLERİNE GÖRE 18. YÜZYILIN İKİNCİ YARISINDA GİRESUN
Authors: Mercimek Yunus
Published: November 2024

Bu çalışmada, Trabzon eyaletine bağlı bir kaza merkezi olan Giresun’dan Divan-ı Hümâyûn’a iletilen şikâyetlerden hareketle, 18. yüzyılın ikinci yarısında Giresun’un idarî, sosyal ve ekonomik durumu incelenmiştir. Bunun için 1, 2 ve 3 numaralı Trabzon ahkâm defterlerinde kayıtlı Giresun ile ilgili hükümler tespit ve transkribe edilmiştir. Daha sonra bu hükümler konularına göre tasnif edilmiş ve her bir konu ayrı başlıklar altında değerlendirilmiştir. Giresun’dan Divan-ı Hümâyûn’a iletilen şikâyetler içinde ilk üç sırada mirî arazi, miras ve eşkıyalıkla ilgili şikâyetlerin yer aldığı görülmüştür. Bunların dışında alacak-verecek, vergi, mülke ve göreve müdahale, aile, vakıf ve komşulukla ilgili şikâyetler de kayıtlara yansımıştır. 18. yüzyılın ikinci yarısında Giresun’da yaşanan sorunları yansıtan bu şikâyetlerlerden şikâyet eden ve edilenlerin kimliği ve sosyo-ekonomik durumu, şikâyetlerin bildirilme şekilleri ve Divan-ı Hümâyûn’un verdiği kararlar hakkında önemli bilgilere ulaşılmaktadır. Şikâyetler aynı zamanda şehrin idarî yapısı, ekonomik durumu ve sosyal yaşamına dair önemli bilgiler vermektedir. İdarî açıdan Trabzon Sancağı’na bağlı bir kaza merkezi olan Giresun, orta dereceli devlet memurlarına verilen bir zeamet içinde yer almaktaydı. İklimine uygun ziraî ürünleriyle ve bir liman kenti olarak dikkat çeken Giresun’un ekonomisi tarım, ticaret ve denizciliğe dayanmaktaydı. Fındık üretimi ve ticaretinin önemli bir ekonomik faaliyet olduğu Giresun’da ahalinin bir kısmı da maden ve zahire başta olmak üzere taşımacılık yapıyordu. Sosyal yaşama dair öne çıkan en önemli husus ise Giresun’un nüfuzlu ayân ailelerinin neden olduğu asayiş olaylarıydı. Bilhassa Dizdarzâde Hüseyin’in öldürülmesinden sonra oğulları tarafından başlatılan olaylar, şehrin asayiş ve ekonomisine büyük zarar vermiştir. Bu durumdan en çok etkilenenler ise Giresun ahalisi ve zeamet mutasarrıfları olmuştur.
RİZE – İKİZDERE AND ÇAMLIHEMŞİN SURVEYS
Authors: Pekşen Okay , Topaloğlu Yasin , Özsoy Nusret Burak
Published: November 2024

Rize, strategically situated in the eastern Black Sea region, has historically served as a crossroads for numerous civilizations and cultures. Despite the region's significance, systematic historical and archaeological research began only in the 1990s. These early studies, which spanned several research seasons, were instrumental in uncovering Rize's rich historical heritage. To further explore this heritage and shed light on its history and archaeology, surveys have been conducted since 2022 in the İkizdere, Çamlıhemşin, and Hemşin districts of Rize Province, authorized by the Ministry of Culture and Tourism. This article provides a comprehensive assessment of the findings from the 2023 surveys in the İkizdere and Çamlıhemşin districts. In İkizdere, research encompassed various neighborhoods, including Çağrankaya, Çarşı, Gündoğdu, Güney, Kirazlı, Yeşilyurt, and Zafer, as well as villages and highlands such as Ayvalık, Bayır, Cevizlik, Demirkapı, Güneyce, Gürdere, Ihlamur, Ilıcaköy, Şimşirli, Tulumpınar, Yağcılar, and Yeralma. In Çamlıhemşin, surveys were carried out in the villages of Sıraköy, Ortaklar, Yazlık, Mollaveyis (Ülkü), Şenköy, Meydan, Şenyuva, Yolkıyı, Yaylaköy, and Ortan, along with their associated highland areas. This research led to the identification of numerous historically significant sites, including the Çikares Settlement, Tekneler Settlement, Yumurtadağ Obsidian Centre, Kale-i Bala, Kale-i Zir, Güneyce Bridge, Andulli Bridge, Şebek Bridge, Trovit Plateau Stone Road, Ortanköy (Goboş) Bridge, Çilanç Bridge, Şenyuva (Çinçiva) Bridge, Yağcılar Historical Houses, Başyayla Rock Depictions, Numanoğlu Mansion and its tamgas, Çolağan Locality Wall Depictions, Karmik Plateau Wall Depictions, Trovit Plateau Wall Depictions, Kozizoğlu Mansion and Wall Depictions, Mollanç Behlül Mansion and Wall Depictions, Kurdoğlu Mansion and Wall Depictions, Meydan Village Wall Depictions, Güneyce Hacı Sheikh Mosque, Şimşirli Village Middle Neighborhood Mosque, Yağcılar Village Konak Mosque, Kurusaha Mosque, and Şenköy Mosque.
SİNOP AYANCIK MUTFAĞINDA MISIR VE MISIRDAN YAPILAN YEMEKLER
Authors: Ayyıldız Sibel , Türker Nuray
Published: November 2024

Bu çalışmanın amacı Ayancık mutfağında önemli bir malzeme olan mısır ununun elde edilme sürecini ve Ayancık mutfağında hazırlanan mısır yemeklerinin belirlenmesidir. Bu amaçla nitel araştırma yönteminin benimsendiği araştırmada Ayancık ve köylerinde yaşayan 12 kadın ile yüz yüze görüşme yapılmıştır. Araştırma sonuçları, Ayancık’ta mısırın fırınlarda kurutulduğunu, değirmenlerde öğütülerek çeşitli boyutlarda mısır unu elde edildiğini, mısır ununun başta mısır ekmeği, mısır keşkeği olmak üzere çorbadan ekmeğe pek çok yemeğin yapımında temel malzeme olarak kullanıldığını göstermektedir. Ayancık’ta mısırın et yemeklerinde, ot ve sebze yemeklerinde, tahıl yemeklerinde, kuru baklagil yemeklerinde ve ekmek yapımında kullanıldığı belirlenmiştir. Ayancık mutfağında mısırın geçmişten günümüze kadar kullanımı devam etmekle birlikte mısırdan yapılan föte gibi içeceklerin unutulmaya yüz tuttuğu belirlenmiştir.
(KİTAP DEĞERLENDİRME: Feridun M. Emecen, DERKENÂR SÖYLEŞİLER, PORTRELER, MAKALELER, Vakıfbank Kültür Yayınları, İstanbul, 2024, 592 s., ISBN: 978-625-6385-78-8.)
Authors: Tütüncü Bekir
Published: November 2024

KİTAP DEĞERLENDİRME/BOOK REVIEW

Feridun M. Emecen, DERKENÂR SÖYLEŞİLER, PORTRELER, MAKALELER, Vakıfbank Kültür Yayınları, İstanbul, 2024, 592 s., ISBN: 978-625-6385-78-8.
Técnicas de agrupamiento y análisis geoespacial - Estudio comparativo en la línea de emergencia de Bogotá
Authors: Sánchez-Moreno Jhohan Andrés , Figueroa-García Juan Carlos
Published: November 2024

El presente trabajo aborda un estudio comparativo entre dos periodos: el primero abarca los dos años anteriores al inicio de la pandemia de covid-19 (2018 y 2019) y el segundo corresponde a los años durante la pandemia (2020 y 2021), en la ciudad de Bogotá, Colombia. Para esto se caracteriza el sistema y, mediante técnicas de agrupamiento y análisis geoespacial, se comparan ambos periodos, permitiendo identificar los cambios en el comportamiento de los incidentes y en la atención brindada, teniendo en cuenta el tipo de vehículo y la prioridad asignada. El análisis espacial identificó que las zonas suroccidental y sur fueron las más afectadas, además, que hay una diferencia en el comportamiento entre el periodo diurno y nocturno. En general, la época de pandemia resultó en mayores tiempos de respuesta, en especial ante incidentes de salud mental, y las zonas mencionadasaumentaron su afectación, debido al crecimiento de los incidentes.
Despenalización de la interrupción voluntaria del embarazo en Colombia: objeción de conciencia y otros retos en su implementación
Authors: Garzón Pulido Lina Soledad , Geney Montes María Cristina
Published: November 2024

En Colombia, actualmente, la interrupción voluntaria del embrazo (IVE) está despenalizada hasta la semana 24 y, posteriormente, previo al término del embarazo, si se cumplen las causales indicadas mediante la sentencia C-355 del 2006, las cuales son: (a) si el embarazo pone en riesgo la salud de la mujer; (b) si el embarazo es producto de una violación, y (c) cuando el feto presenta malformaciones incompatibles con la vida. Este trabajo tiene por objeto describir la situación de la IVE en Colombia para los médicos y los pacientes desde su despenalización, mediante un análisis de la literatura y la jurisprudencia. Se caracterizaron los problemas en el ejercicio de la objeción de conciencia y las barreras de acceso a los servicios de IVE. Con base en estos hallazgos, se proponen algunas estrategias para mejorar la implementación de la norma en beneficio de los pacientes y respetar los derechos de los médicos.
Contenidos éticos en la regulación jurídica del cuidador primario
Authors: Reyna Lara Mauricio
Published: November 2024

Este artículo presenta una reflexión sobre el papel que juegan los cuidadores primarios informales. Las actividades que realizan tanto el cuidador formal como el informal son en realidad las mismas, la diferencia radica en que los primeros han sido capacitados y certificados como, por ejemplo, las enfermeras (cuidadores formales). Por su parte, los familiares no cuentan frecuentemente con una capacitación adecuada, pues no existe una alfabetización enfocada en el cuidado de la salud del otro. Recientemente se crearon programas públicos que fomentan el desarrollo de habilidades básicas para el cuidado de otros; no obstante, la retribución social para los cuidadores informales y, más importante, la económica, son áreas que competen al sector gubernamental y jurídico. Es necesaria la regulación jurídica del cuidador primario debido a la magnitud del costo en salud que conlleva responsabilizarse de otro, como el desarrollo de enfermedades, aumento en el desgaste físico, incidencia de psicoestresores, síntomas por sobrecarga de trabajo y afectación a la salud mental. Se debe recordar también que, de acuerdo con la bioética y los derechos humanos, tanto el cuidador como el que es cuidado cuentan con un valor inherente como seres humanos y merecen una vida de calidad.
FROM AFRICA TO BRAZIL, A PARALLEL BETWEEN RELIGION AND TRADITIONAL YORUBA MEDICAL SYSTEMS
Authors: Da Silva Jonatas J. L. S. , Leitão Suzana G , Oliveira Danilo Ribeiro de
Published: November 2024

The Yoruba are one of the largest ethnolinguistic groups in West Africa. Among the Yoruba and their descendants, medicine and magic are given the same name, oogun, due to the similarity of their practices. From this point of view, Yoruba Traditional Medicine is interconnected with Yoruba Traditional Religion, including a series of religious and therapeutic practices employed in general health care and emotional well-being services. With their forced arrival in America, following Portuguese colonization, these people brought their rituals and their vision of medicine to Brazil, giving rise to the religion known as Candomblé. The objective of this work was to conduct a review study on Traditional Medicine employed by African people of Yoruba ethnicity in Nigeria, drawing a parallel with their descendants (direct and indirect) who practice Candomblé in Brazil, from an epistemological perspective, reflecting on the religiosity and health of these people and the challenges for its consolidation as a traditional medical system.
DIREITO, CONSUMISMO E SUSTENTABILIDADE: um olhar sobre este tripé
Authors: Alves Felipe Freitas de Araújo , Silva Renan Antônio da
Published: November 2024

Diante de uma pesquisa bibliográfica, qualitativa e descritiva, partindo de uma análise das bibliografias, a hipótese da relação entre Direito, Consumismo e Sustentabilidade será desenvolvida de forma a se conseguir aclarar os objetivos deste artigo: explicar os conceitos acima mencionados, encontrar a relação entre Consumismo e Sustentabilidade e indicar como o Instituto do Direito pode colaborar com um planeta mais sustentável financeiramente, ambientalmente e sadiamente, em esferas individuais e coletivas. Com o desenrolar do século XXI e a crescente aceleração do consumo, em suas várias faces, chegamos em um ponto em que a Terra já não mais se sustenta, trazendo consequências múltiplas ambientais e para a saúde humana. É desta maneira que a regulamentação trazida pelo Direito deve proporcionar mecanismos de consumo sustentável e coibir práticas de incentivo ao consumo desenfreado. Como conclusão, se notou a relação próxima entres estes três conceitos e a necessidade de que a regulamentação jurídica interfira nos moldes de consumo perniciosos para as finanças pessoais, saúde dos indivíduos e equilíbrio ambiental
CONSUMISMO E NATUREZA: a ética da responsabilidade na busca da preservação
Authors: Alves Felipe Freitas de Araújo , Approbato Ana Patrícia Ribeiro , Silva Renan Antônio da
Published: November 2024

Não há como negar que os impactos ambientais decorrentes das ações humanas têm ganhado grande destaque, em especial as vinculadas ao consumo. O presente artigo científico tem por objetivo demonstrar a importância da preservação do meio ambiente, com base em diretrizes éticas, de modo a garantir a qualidade de vida da presente e das futuras gerações, realizando, para tanto, uma pesquisa qualitativa do tema a ser examinado, utilizando-se a técnica da pesquisa bibliográfica e documental, com análises de registros doutrinários e artigos científicos capazes de demonstrar a possibilidade de um consumo sustentável e consciente envolto em atitudes éticas, tudo ajustado ao quanto disposto no art. 225 da Constituição Federal. Assim, será possível concluir, com referida análise, que as atitudes do ser humano, sem observância dos limites da natureza, das diretrizes legais e da ética poderão causar ao meio ambiente danos irreversíveis.
THE INDIGENOUS REVOLUTION IN THE AMERICAS: perceptions obtained among the Laklãnõ indigenous people
Authors: Virgilio Jefferson
Published: November 2024

The paper presents a little-explored facet of indigenous activism in Brazil: The empirical material is based on research that has been carried out with the Laklãnõ people since 2016 and which has been discussed in different spaces. The focus is to demonstrate how these indigenous are protagonists of an unprecedented revolutionary process - and outside of a Western-European orientation. This revolutionary process is articulated in a larger network with other indigenous peoples in America who carry out other anti- system fronts, not necessarily being in contact with each other, or even knowing of the actions being carried out. I specifically discuss the practical actions of the Laklãnõ people that enhance the results of this revolutionary process. The paper suggests an articulation of these and other fronts of action as constituents of a greater engine for the development of a particular model of indigenous counter-colonialism with a focus oriented on safeguarding a plant species (Zág - Araucaria) at extreme risk of extinction and which has been sacred to this people for thousands of years through the appropriation and re-signification of a series of devices that are identified by the natives as <<weapons (of colonization and destruction) of the whites.
Il contributo delle Digital Humanities per un approcio allo studio dell’epigrafia Ispano-Romana
Authors: Bastero Acha Marina
Published: November 2024

Within the various research areas of Ancient History, Digital Humanities have gained a significant role in recent years. However, in the more specific field of Epigraphy, which is the topic of this contribution, although the usefulness of Information and Communication Technologies (ICTs) has begun to be evaluated, these resources have largely been used as a complementary tool and not as an integral part of the epigraphic discipline. For this reason, it can be to present and describe those ICT-related tools that can be consider fundamental for a modern epigraphic study, with a particular focus on the Latin epigraphy of Roman Hispania.
An Investigation into the Effects of Varying Seasons, Indole-3-Butyric Acid (IBA) and Rooting Media on the Rooting and Longevity of Air-layered Water Apples (Syzygium samarangense L.)
Authors: Giriprasath R.S. , Umesh B.C. , Vinay T.V. , Jeevitha D. , Manjula B.S. , Ranchana P. , Suresh V.
Published: November 2024

Background: The variation observed in sexual propagation often results in slow growth and fruit development, attributed partly to insufficient photosynthates during early growth stages. To address this challenge, vegetative propagation methods such as air layering offer promising solutions. This technique not only accelerates productivity but also enhances the quality of water apples. Recognizing the importance of air layering in water apple cultivation, this experiment was conducted to standardize this technique by examining the impact of different seasons and planting media in the western tropical wet and dry climate of Tamil Nadu. Methods: The study was conducted to evaluate the variables affecting air layering in water apples in Coimbatore district. The experiment was carried out with three different factors like seasons [August (S1), September (S2) and October (S3)] and IBA [applied at different concentrations of 2000 mg/L (I1), 3000 mg/L (I2) and 4000 mg/L (I3)] along with different rooting media: Cocopeat (M1) and Sphagnum moss (M2). The factorial randomized complete block design (FRCBD) was laid out for statistical analysis. Result: Sphagnum moss performed as a better rooting medium due to its high water holding capacity and good aeration. Increase in the number and early formation of roots were due to more rain fall and high relative humidity in August, that resulted in more nutrient uptake and structural stability. The discovery aids in determining the optimal conditions, including season, dosage and combination (4000 mg/L IBA with sphagnum moss applied in August), for successful air layering in water apple.
Characteristics of lower extremity ulcers among patients treated at Prof. Dr. I.G.N.G. Ngoerah General Hospital, Denpasar, Bali
Authors: Puspita Sari Luh Gede Melia , Suryawati Nyoman
Published: November 2024

Lower extremity ulcers are one of the ulcers that are difficult to heal. This condition causes significant morbidity, mortality, costs, and reduces the quality of life. Epidemiological studies in Indonesia often focus on diabetic foot ulcers, so a general description of lower extremity ulcers is still lacking. This study aimed to determine the characteristics of lower extremity ulcers in outpatients at the Dermatology and Venereology Outpatient Polyclinic, Prof. Dr. I.G.N.G Ngoerah General Hospital, Denpasar, Bali. The data were taken retrospectively from medical records from January 2018 until December 2021. A total of 15 subjects were enrolled in this study. Among the subjects, 8 (53.3%) were male and 7 (46.6%) were female. The age group of 40 yo and over dominated this study (60%). The common ulcer predilection was on the cruris (42.1%) and the wound culture results were dominated by Staphylococcus aureus (40%). Comorbidities were found in 7 subjects (46.7%) and the majority was hypertension (42.8%). Several subjects also had additional diagnoses at the time of the visit, including Morbus Hansen (60%), deep vein thrombosis (10%), cellulitis (10%), pyoderma gangrenosum (10%), and systemic lupus erythematosus (10%). In conclusion, the most characteristics of lower extremity ulcer patients at Prof. Dr. I.G.N.G Ngoerah General Hospital  are males, age group > 40 yr, with cruris as a predilection, and hypertension as the most common comorbid.
CEA and Cyfra 21-1 linked to serial miRNA expressions of advanced-stage non-small cell lung cancer in Indonesia
Authors: Hanafi Arif Riswahyudi , Jayusman Achmad Mulawarman , Imelda Priscillia , Alfasunu Serafim , Sadewa Ahmad Hamim , Pramono Dibyo , Heriyanto Didik Setyo , Haryana Sofia Mubarika , Kresno Siti Boedina
Published: November 2024

Globally, lung cancer is one of the cancers leading to dead, dominated by non-small cell lung cancer (NSCLC). In a previous study has shown those serial miRNA expressions (miR-148, miR-34, miR-222, and miR-155) had prognostic value in advanced-stage NSCLC patients. Meanwhile, CEA and Cyfra 21-1, pulmonary tumor markers, are sometimes considered in the Department of Pulmonology, Dharmais Cancer Hospital, Jakarta, although they are not used in routine clinics for prognostication. Both miRNA and CEA-Cyfra 21-1 are valuable biomarkers in NSCLC. This study aimed to evaluate their correlation between CEA and/or Cyfra 21-1 with miRNA expressions in NSCLC patients. It was a cohort retrospective study using data from the previous study. The correlation between variables was analyzed by Spearman-rho. A positive correlation was observed between CEA and Cyfra 21-1 with miR-148, miR-222, and miR-155 [(CEA: p=0.00369, r=0.522; p=0.00242, r=0.542; p 0.00106, r=0.576) (Cyfra: 21-1= p 0.01252, r=0.378; p=0.00035, r=0.519; p=0.01532, r=0.368)]. In conclusion, CEA and Cyfra 21-1 correlate with miR-148, miR-222, and miR-155 expressions in advanced-stage NSCLC.
The correlation between stress level and eating disorder syndrome in preclinical medical students at Faculty of Medicine and Veterinary Medicine, University of Nusa Cendana, Kupang, East Nusa Tenggara
Authors: Djema Marceline Consolatrix Cheyene , Sagita Sidarta , Woda Rahel Rara , Legoh Dickson
Published: November 2024

Nowdays with various kinds of needs and demands in life that must be met at any time can cause stress of someone. Medical students are often experience high level of stress due to the demands of high education standards requirements. Continous chronic stress can affect eating behaviour lead to the potential cause of eating disorder syndrome (EDS). This study aimed to evaluate the correlation between stress level and EDS in preclinical medical students of Nusa Cendana University, Kupang, East Nusa Tenggara. It was an analytic observational with a cross sectional design conducting on the preclinical medical students by filling out depression anxiety stress Scale (DASS-42) and eating attitude test (EAT-26) questionnaires. Respondents were selected by the probability sampling method with a stratifies random sampling technique. A total 141 respondents who met the inclusion and exclusion criteria were recruited. Bivariate analysis by using the Wilcoxon Theta correlation test was performed. Among respondents involved in this study, 13 (9.2%) respondents did not experience stress and 128 (90.8%) experienced stress including 43 (30.5%) mild stress, 68 (48.3%) moderate stress, and 17 (12.3%) severe stress. The EDS was observed in 15 (10.6%) respondents. A significant moderate correlation between stress level and EDS was indicated (θ = 0.58). In conclusion, there is correlation between stress level and EDS on preclinical medical students of Nusa Cendana University, Kupang.
High-sensitivity C-reactive protein/albumin (hs-CRP/albumin) ratio as a predictor of deterioration of clinical outcome in central nervous system infections
Authors: Hayati Hanifah Fajarisna , Satiti Sekar , Paryono Paryono , Intansari Umi , Sutarni Sri , Subagya Subagya , Indarwati Indarwati , Setyopranoto Ismail
Published: November 2024

Central nervous system (CNS) infections such as encephalitis, meningitis, or myelitis have high morbidity and mortality in Indonesia. High sensitivity C-reactive protein (hs-CRP) is a sensitive marker of acute inflammation, while albumin is the most abundant protein component in plasma and cerebrospinal fluid (CSS). Infection triggers an inflammatory response so that an increase in the hs-CRP/albumin ratio (CAR) can be a predictor of worsening clinical outcome in patients with CNS infections. However, studies examining the predictor value of serum and CSF CAR on worsening clinical outcomes of patients are limited, particularly in CNS infections. The purpose of this study was to prove the CAR as a predictor of worsening clinical outcome in patients with CNS infections.  It was an observational study using a prospective cohort design. Fifty subjects recruited until October 2021 at Dr. Sardjito General Hospital were involved.  The multivariate regression analysis showed that serum CAR (OR=3.604; 95%CI=1.487-8.736; p =0.005) could be a single predictor. However, by combining three variables, namely serum CAR, CSF CAR, and decreased consciousness at admission, could be a stronger predictor of worsening clinical outcome in patients with CNS infection (AUC = 97.1%; 95%CI = 0.929-1.00; p <0.001). The optimal cut-off value for serum CAR was 1.35 (Youden index = 0.88, sensitivity = 96%, specificity = 92%) while for CSF CAR was 0.14 (Youden index = 0.60, sensitivity = 76%, specificity = 84%). In conclusion, a combination predictive model of three variables, namely serum CAR, CSF CAR, and awareness at admission can be a stronger predictor of clinical outcome in patients with CNS infection than serum CAR alone.
Papulopustular demodicosis: a case report
Authors: Mariyani Sri , Etnawati Kristiana
Published: November 2024

Primary demodicosis is an infestation of Demodex colonization >5 mites/cm2 without pre-existing or concomitant inflammatory skin disease. Primary demodicosis is divided into 3 variants i.e. spinulata, papulopustular and nodulocystic. Several topical and systemic agents are used in the Demodex facial treatment. A 22 y.o. man complained of acne on his face three months ago. On physical examination, there were pustules, multiple erythematous papules, ice pick atrophic scars, and box and rolling scars. KOH examination found the Demodex number > 5 mites/cm2. No spores were found. The patient received oral and topical metronidazole therapy. Papulopustular demodicosis is a follicular inflammation caused by Demodex mites. The inflammatory stage shows a predilection for the perioral, periorbital, and periauricular regions. According to the pattern of morphology and localization of the centrofacial area, some cases of demodicosis are often referred to as Rosacea-like (rosaceiform) demodicosis. The treatment goals are to reduce the overall number of mites and treat the underlying condition. This paper reports a case of papulopustular demodicosis of the face. The diagnosis was made by history taking and physical examination using the diagnostic criteria for demodicosis. Clinical improvement was obtained after oral and topical metronidazole therapy for two weeks.
Topical anti-aging agents: state-of-the-art review
Authors: Prakoeswa Flora Ramona Sigit , Maharani Faradiba , Satria Yohanes Aditya Adhi , Awanis Ghina Shabrina , Febrianty Astrida Fesky
Published: November 2024

Skin aging can be divided into intrinsic and extrinsic aging. Even though it is inevitable, symptoms of skin aging are a common concern for patients. As a result, there is a surge in the making of anti-aging cosmeceuticals. However, there is a lack of evidence-based data to support the usage of topical preparations as anti-aging treatments. Therefore, further studies are needed to explore topical treatment options for skin aging. This literature review discusses the mechanism of commonly used topical anti-aging agents and their adverse reactions.
Dermoscopy features on dermatomycosis
Authors: Lubis Flora Marlita
Published: November 2024

Dermoscopy is a non-invasive tool mainly used to clarify pigmented and nonpigmented skin lesions. Based on its physical properties, dermoscopy is divided into non-polarized and polarized. Dermoscopy examination is a diagnostic technique that is often performed on skin disorders, including skin disorders due to fungal infections. Some of the fungal diseases that are examined bydermoscopy are tinea capitis, pityriasis versicolor and onychomycosis. The dermoscopy features found in tinea capitis are comma hair, corkscrew hair, black dots and short hair. Onychomycosis found dermoscopy chromonychia, white longitudinal stripes and opaque nails (cloudy). The dermoscopy in pityriasis versicolor shows hypopigmented and hyperpigmented patterns.
Translation and Adaptation of the STOPP/START Criteria Version 3 for Potentially Inappropriate Prescribing in Older People to European Portuguese: A Study Protocol
Authors: A. Rodrigues Daniela , Roque Fátima , Herdeiro Maria Teresa , Monteiro Luís
Published: November 2024

Introduction: As the global population ages, managing medication use in older adults becomes increasingly complex due to polypharmacy and the associated risks of adverse drug events. To improve the safety and appropriateness of medication use in the older population, tools like the Screening Tool of Older Persons’ Prescriptions (STOPP) and Screening Tool to Alert doctors to Right Treatment (START) criteria have been developed. The availability of updated criteria is crucial to better support healthcare professionals in Portuguese-speaking regions. The aim of this study is to translate and validate the STOPP/START version 3 criteria for Portuguese, providing an updated and useful tool for healthcare professionals.Methods and Analysis: This study will be conducted through four phases: I) translation of the STOPP/START version 3 criteria to European Portuguese; II) collection of sociodemographic, clinical, and medication data; III) intrarater reliability study; and IV) interrater agreement study. This study obtained ethics approval by the Ethics Committee of the Administração Regional de Saúde do Centro, Portugal. The availability of the translated criteria will enable the integration of STOPP/START version 3 into clinical practice in Portugal, facilitating improved medication safety and appropriateness. This integration is expected to lead to better management of polypharmacy and a reduction in adverse drug events, ultimately enhancing patient outcomes and supporting evidence-based prescribing practices.
The climates of the world’s wine regions
Authors: Puga German , Anderson Kym
Published: November 2024

The aim of this article is to describe the climates of the world’s wine regions and discuss implications of climate change for those regions. In doing so, we summarise a recent scientific journal article: Puga et al. (2022). We also incorporate insights from other work – part of which is first published here.
To -8 MPa and back: in-situ annual water relation in non-irrigated olive trees
Authors: Barzilai Oded , Avraham May , Wagner Yael , Dag Arnon , Hochberg Uri
Published: November 2024

Olive trees are known for their capability to endure and recover from low stem water potentials (Ψstem < -6 MPa) and even maintain substantial gas exchange under such conditions. In the current experiment, we tested the physiological responses of mature olive trees in-situ while enduring such Ψstem under field conditions for seven months of rainless Israeli summer. To characterize olive trees' seasonal response to drought, we followed the annual patterns (a measurement day once a month) of Ψstem, gas exchange, osmotic adjustment, and hydraulic conductance of mature bearing olive trees that were disconnected from irrigation. We found that through the dry summer, the trees gradually dehydrated to a minimum of -8.1 MPa in October. An increase of 1320 mmol/kg in the leaf osmotic concentration through the summer was part of the tree's acclimation to the low Ψstem. Surprisingly, despite the low Ψstem that have probably led to substantial xylem cavitation, the trees maintained stomatal conductance of at least 0.023 mol m-2 s-1 and positive assimilation throughout the year. Following the winter rains, the plants recovered their Ψstem, gas exchange, and hydraulic conductance to maximal values. The results demonstrate olives' remarkable ability to tolerate Ψstem while maintaining above minimal gas exchange and producing fruits.
La marque « Végétal local » vue par EDF : analyse de filière et retours d’expérience
Authors: DIECKHOFF Léa , ROULEAU Juliette , DELESSE Florine , CLERMONT Sandra
Published: November 2024

L’entreprise EDF, en tant qu’aménageur d’infrastructures majeures et gestionnaire de plus de 30 000 hectares de foncier terrestre en France continentale, collabore depuis plus de dix ans avec les Conservatoires botaniques nationaux sur l’origine du matériel végétal utilisé dans ses projets d’aménagement, de réhabilitation post-chantier et de restauration écologique. Cette collaboration se traduit notamment par un partenariat national initié dès la création en 2015 de la marque « Végétal local ». Cette dernière, animée par le réseau des Conservatoires botaniques nationaux, l’Afac-Agroforesteries et Plante & Cité, vise à garantir l’utilisation de matériel végétal adapté au territoire où les projets sont mis en place, dans un souci de protection de la diversité génétique. L’article présente la vision d’EDF sur la structuration de la filière, qui se distingue par un réseau d’animateurs locaux, un lien avec les acteurs de l’économie des territoires et une forte implication du monde de la formation et de la recherche. Un retour d’expérience sur les projets portés par EDF avec du « Végétal local « permet de mettre en lumière les avantages de la marque, mais aussi les défis qui vont de pair avec son utilisation.
The Missing Piece of the Quantum Puzzle
Authors: Mardari Ghenadie N.
Published: November 2024

Modern theoretical physics is built around two myths. The first one is that quantum observables are inseparable from the act of measurement. In some cases, this “observer effect” is supposed to be so strong that some qualities are mutually exclusive. Though, what is the difference between quantum contextuality and classical contextuality? This is where the second myth comes in. Objectively incompatible properties are treated as if they do not exist in classical physics. Instead, only two types of observables are considered: the ones that can occur at the same time as part of a single system, and the ones that are produced by measurement artifacts. As a result, we have a gap between two incomplete theories: a “quantum” theory without objective processes and a “classical” theory without mutually exclusive events. Together, they create the false impression that quantum entanglement is non-local. This is illustrated below with a clockwork mechanism for predetermined sequential properties. The system produces super-quantum Bell violations, as well as the features of quantum monogamy, in ideal experiments without loopholes. A separate illustration, with a classical fluid flow-splitter, is used to explain quantum-like Bell violations with independent and random measurement settings at remote stations. Objective contextuality is the missing piece of the quantum puzzle.
Impact Resistance of Potential Replacement Materials for Large Power Transformer Tanks
Authors: Williams Jide , Hoffman Joseph , Predecki Paul , Kumosa Maciej
Published: November 2024

The protective effect of polymer coatings on Polymer Matrix Composite (PMC) panels against high-velocity ballistic impacts specifically as a potential replacement material for Large Power Transformer Tanks (LPT) has not been widely investigated. In particular, numerical predictions of the ballistic performance of the panels with coatings under impact are not available which is not surprising considering the complexity of the problem due to the prohibitive cost of the experimental testing. This numerical study was performed to understand the potential beneficial effects of a polyurea (PU) coating on PMCs, in application in LPT tanks. Glass fiber/epoxy and carbon fiber/epoxy composite panels individually and in a hybrid combination were subjected to 400 m/s ballistic impact. Using finite elements, the impact damage evolution for uncoated panels was investigated to determine the arrest depth as a function of panel thickness. Subsequently, the panels were evaluated for their ballistic response in the presence of PU coatings. It has been shown numerically for the first time that the addition of PU was three times more efficient in protecting the glass and carbon fiber panels against penetration than by increasing their thickness. In all three cases, adding a coating of PU decreased the estimated cost, mass, and thickness of the panels required to prevent penetration of the modeled projectile.
Duality of the Navier-Stokes Dynamics and Lack of Finite-Time Explosion
Authors: Migdal Alexander
Published: November 2024

We describe the duality of incompressible Navier-Stokes fluid dynamics in three dimensions, leading to its reformulation in terms of a one-dimensional momentum loop equation. The momentum loop equation does not have finite-time blow-up solutions. The decaying turbulence is a solution of this equation equivalent to a string theory with discrete target space made of regular star polygons and Ising degrees of freedom on the sides. This string theory is solvable in the turbulent limit, equivalent to the quasiclassical approximation in a nontrivial calculable background. As a result, the spectrum of decay indexes is analytically computed, and it agrees very well with real and numerical experiments. Among the decay indexes there are complex conjugate pairs related to zeros of the Riemann zeta function. The Kolmogorov scaling laws are replaced by certain number theory functions, nonlinear in log-log scale.
Environmental Factors Influencing Species Richness Expression In Grasslands Of The Colombian Orinoquia
Authors: Minorta-Cely Vladimir , Niño Larry , Rangel-Ch. J. Orlando , Sánchez-Mata Daniel
Published: November 2024

The relationships between environmental characteristics and species richness in the grasslands of the Colombian Orinoquia are presented and analyzed using an ordinal logistic regression model. Ordinal and scale covariates were included, and their bivariate significance was assesed using Spearman's rho and Kendall's Tau-b. The covariates that showed statistical significance with the weighted richness thresholds (WRT) and defined the model were soil depth and soil moisture regime, both of which had positive correlations. In contrast, the percentage of bare soil and the monthly minimum temperature showed negative correlations. This contribution highlights the relevance of articulating and combining the floristic and phytosociological characterization of grassland vegetation to advance predictive studies aimed at defining and understanding the potential divergent relationships between vegetation and basic attributes of the natural environment, along with their implications for conservation.
A Computational Model of Minimal Phenomenal Experience (MPE)
Authors: Sandved-Smith Lars
Published: November 2024

Minimal phenomenal experience (MPE), or "pure consciousness," represents a fundamental form of conscious experience characterised by reflexive meta-awareness and the absence of many features of regular phenomenology. It has been described as e.g. non-conceptual, atemporal, non-egoic and aperspectival. This paper aims to develop a computational model of MPE using the mathematics of variational free energy minimization derived from the free energy principle (FEP). I employ a computational neurophenomenology approach, formalising key phenomenological features of MPE within the active inference framework. The model incorporates parametric depth, allowing for higher-order inferences about generative model parameters. I relate specific model parameterisations to reported MPE qualities such as meta-awareness, equanimity, effortlessness, and non-conceptuality. The proposed model suggests that MPE arises when an agent achieves very low free energy through self-directed awareness and modulation of their generative model, particularly by emphasising awareness of awareness itself. The model predicts elements of MPE phenomenology including a sense of effortlessness, timelessness, and the potential for a "zero-person perspective”. The implementation details for a simulation of the proposed model are outlined, as well as directions for empirical validation.
Beyond Temperature Peaks: The Growing Persistence and Intensity of Tmin and Tmax Heatwaves in Portugal’s Changing Climate (1980/1981–2022/2023)
Authors: Espinosa Luis Angel , Portela Maria Manuela , Ocampo-Guerrero Nikte
Published: November 2024

This study investigates the trends and characteristics of heatwaves in mainland Portugal from 1980/1981 to 2022/2023 using ERA5-Land reanalysis data. This research uses the Heatwave Magnitude Index (HWMI) to identify heatwave days for minimum (Tmin) and maximum (Tmax) temperatures across 15 grid-points representing Portugal’s diverse geography and climate. Three key annual parameters are analysed: the number of heatwave days (ANDH), the average temperature during heatwaves (AATW), and the intensity of heatwave events (AIHD). Results reveal a consistent increase in heatwave persistence throughout mainland Portugal, with more pronounced trends observed for Tmax compared to Tmin. ANDH Tmin shows upward trends across all grid-points, with increases ranging from 0.8 to 4.2 days per decade. ANDH Tmax exhibits even more significant increases, with 11 out of 15 grid-points showing statistically significant rises, ranging from 2.2 to 4.4 days per decade. Coastal areas, particularly in the south, demonstrate the most substantial increases in heatwave persistence. The intensity of heatwaves, as measured by AIHD, also shows positive trends across all grid-points for both Tmin and Tmax, with southern locations experiencing the most significant increases. The study also discusses decadal trends in annual averages of Tmin and Tmax, as well as extreme measures such as annual minimum (AMIN) and annual maximum (AMAX), daily temperatures spatially represented across mainland Portugal. These analyses reveal widespread warming trends, with more pronounced increases in Tmax compared to Tmin. The AMIN and AMAX trends further corroborate the overall warming pattern from the heatwave analyses, with notable spatial variations observed. The findings indicate a substantial worsening in the occurrence, duration, and intensity of heatwave events. This increased persistence of heatwaves, especially evident from the early 2000s onwards, suggests a potential climate regime shift in mainland Portugal. The results underscore the need for adaptive strategies to address the growing challenges posed by more frequent and intense heatwaves in the region.
Enhancing the Mechanical Properties of Sawdust Concrete with Silica Fume, Metakaolin, and Marble Powder
Authors: Rajaee Arash , Sadeghzadeh Mohammadreza , Shekhi Morteza , Yousefi Mohammadsadra , Abrishami Saeed
Published: November 2024

This research explores the innovative use of sawdust as a sustainable aggregate in concrete, addressing both environmental and structural challenges. The study investigates the effects of incorporating sawdust at varying proportions (15%, 25%, and 35%) into concrete mixtures, aiming to reduce carbon emissions and promote lightweight construction. Recognizing the negative impact of waste glass powder on concrete strength, this research introduces silica fume (SF), metakaolin (MK), and marble powder (MP) as potential additives to enhance the compressive strength and reduce the specific weight of sawdust concrete. The experimental program involved 13 concrete mixtures, with SF, MK, and MP added at 5%, 10%, and 15% by mass to a 25% sawdust mix. Results indicate that increasing sawdust content significantly decreases compressive strength, with reductions from 31.655 MPa in the control to 6.291 MPa at 35% sawdust. However, the addition of SF and MK notably improved strength, with SF enhancing it by 68.8% at 10% addition and MK by 69.3% at 5%. MP, while less effective, still increased strength by 42.9%. Sawdust addition consistently reduced concrete density, from 2399 kg/m³ in the control to 2091 kg/m³ at 35% sawdust. SF further reduced density, whereas MK and MP increased it. The study concludes that 10% SF or 5% MK are optimal for improving sawdust concrete properties, offering a balance of enhanced strength and reduced weight. This research contributes to sustainable construction practices by demonstrating the viability of sawdust and specific additives in creating environmentally friendly, lightweight concrete solutions.