bluuebunny/crossref_metadata_2025 huggingface dataset:
KELAYAKAN SCRAPBOOK SUB MATERI PEMANFAATAN KEANEKARAGAMAN HAYATI INDONESIA
Authors: Septiani Uray Rina , Yeni Laili Fitri , Marlina Reni
Published: June 2022

This research aimed to determine the student learning outcomes with cooperative learning models assisted by flipbook media in the material of the human motion system in class VIII SMP Negeri 14 Pontianak. The form of this research was quasi-research (Quasy Experimental Design) with the research design used was Non-equivalent Control Group Design. The research sample was class VIII I as an experimental class and VIII H as a control class, with intact group sampling techniques. The instruments used were multiple choice tests totaling 20 questions. The average student learning outcomes in the experimental class was 16.54, while in the control class was 15.52. The results of the Mann Whitney U test analysis showed that the value of Zhitung<-Ztabel is -2.40 <-1.96, then Ho was rejected and Ha was accepted, meaning that there were differences in learning outcomes of students taught using cooperative learning models assisted by flipbook media and students who are taught using conventional learning models. The value of the effect size was obtained by 0.72 with the medium category, giving an effect of 26.42% on the learning outcomes of students in human motion system material in class VIII of SMP Negeri 14 Pontianak.
KELAYAKAN MEDIA FLICHART KEANEKARAGAMAN JAMUR KALIMANTAN BARAT SUBMATERI PENGELOMPOKAN JAMUR KELAS X SMA
Authors: Sapardi Sapardi
Published: June 2022

This study aims to describe the feasibility of flipchart media about mushroom diversity in West Kalimantan from the results of several studies in the Biology Education study program in mushroom grouping submersion in class X SMA and describe the development of mushroom diversity flipchart media in West Kalimantan for learning mushroom grouping submersion in class X SMA . The form of research used is to provide an overview of the results of several studies that have been carried out in the Biology Education Study Program FKIP Untan on mushroom diversity in West Kalimantan, which is implemented in flipchart media. Flipchart media were tested by experts, namely two lecturers in Biology FKIP Untan and three biology class X high school teachers. The selected biology teachers are SMA Negeri 1 Sungai Raya, SMA Negeri 2 Sungai Raya and SMA Santun Untan. Based on the validator's evaluation, the flipchart is included in the valid category with an average total validation of 3.6 and is feasible/ can be used as a learning medium in the mushroom grouping class X submersion. KEY WORDS: Feasibility, Flipchart, Mushroom Grouping
KELAYAKAN BOOKLET SUBMATERI STRUKTUR DAN FUNGSI JARINGAN TUMBUHAN PADA TANAMAN MONOKOTIL
Authors: Oktaviani Ersa , Daningsih Entin , Marlina Reni
Published: June 2022

This study aimed to determine the feasibility of booklet of plant structure and function tissue submateria lwith additional information about the stomatal distribution and area as teaching material. The research method used was descriptive. Validation by 5 validators consisting of 2 lecturers of the Faculty of Teacher Training and Education (FKIP) Tanjungpura University and 3 biology teachers of class XI SMA using the 2013 curriculum and school accreditation at least B. The assessment uses 5 aspects and 12 criteria. The results of the validation analysis of teaching materials obtained an average CVR and CVI value of 0.95. The booklet needs improvement on content graphing. Therefore, the booklet teaching submaterial with additional information based on the stomatal distribution and area in monocots plant was suitable to be used in the learning process of the structure and function of plant in class in XI SMA.
KELAYAKAN HANDOUT STRUKTUR DAN FUNGSI JARINGAN TUMBUHAN DENGAN TAMBAHAN DISTRIBUSI STOMATA DAN LAJU TRANSPIRASI
Authors: Salina Novi , Daningsih Entin , Marlina Reni
Published: June 2022

This study aimed to determine the feasibility of handout of submaterial structure and function of plant tissue with additional information about the stomatal distribution and transpiration rate used as teaching material. The research method used a descriptive. The validation was conductive by 5 validators and the validator was divided into two, namely the instrument validator and the handout teaching material validator. The instrument validator consisted of 2 Biology Education lecturers at FKIP UNTAN and 1 high school biology teacher in senior high school grade XI pontianak. The handout teaching material validator consisted of 2 Biology Education lecturers at FKIP UNTAN and 3 biology teachers senior high school grade XI pontianak using the 2013 curriculum and school accreditation A. The assessment used 5 aspects and 10 criteria. The results of handout validation of structure and function of plant tissue submaterial in senior high school grade XI of teaching materials with additional information based on the stomatal distribution and the transpiration rate in six monocot plants obtained an average CVR and CVI results 0.99 categorized valid and feasible to be used in the learning process. However, further research was needed on the effectiveness of learning outcomes used handout teaching materials in the learning process.
PENGARUH MODEL PEMBELAJARAN SAVI BERBANTUAN FLIPCHART TERHADAP HASIL BELAJAR PESERTA DIDIK PADA MATERI KEANEKARAGAMAN HAYATI
Authors: Fransiska Nopiani , Ningsih Kurnia , Marlina Reni
Published: June 2022

This study purpose to determine the effect of the SAVI (Somatic Auditory Visualization Intellectualy) learning model assisted by flipchart media on the learning outcomes of stundents in the concept of biodiversity concept in class X SMA PGRI 1 Pontianak. The from of research used was quasy experimental design with a nonequivalent control group design. The research sample consisted ot two classes, namely class xa as an experimental class and class xb as acontrol class, the technique used in sampling is technique. The instrument used was a multiple choice with 20 items. The average score of the experimental class learning outcomes 14,21 while the control class 12,83. U-Mann Whitney test result abtained that Zcount (-2,47) < -Ztable (-1,96) these result indicate there are differences in learning outcomes of students who are taught with the SAVI learning model assisted by flipchart media and who are taught using conventional models. Through the calculation of the effect size, the SAVI learning model assisted by flipchart media has an effect of 25,17% on the learning outcomes of grade X stundest of SMA PGRI 1 Pontianak.
KELAYAKAN BIOCARD PADA SUBMATERI TUMBUHAN PAKU KELAS X SMA
Authors: PEBUANTI PEBUANTI PEBUANTI
Published: June 2022

This study aims to determine the feasibility of learning media Biocard and species diversity of ferns (Pteridophyta) in the natural tourism area of Riam Merasap Bengkayang. This research comprised two stages. The first stage is observing the diversity of ferns in the natural tourism area of Riam Merasap Bengkayang and the second stage is developing media Biocard based on the results of the observations. The form of this research is quantitative with a descriptive method. Samples were taken using a purposive sampling technique with multiple plot methods. The findings showed that there were 11 species of ferns found in a closed area (canopy) and 6 species in an open area. Of the two location conditions, the highest Importance Value Index (INP) is in the open area. The highest INP value in open areas is 59.790% on Nephrolepis hirsutula (Frost.) Pr, species, and the lowest INP is 6.809% on Lygodium circinatum (Burm.f.) Sw. The highest INP in the covered area is 45.465% on Stenochlaena palustris (Burm.) Bedd. species and the lowest INP is 1.460% on the Pitrogramma calomelanos, Drymoglossum piloselloides (Linn.) species, and the Diplazium eculentum (Retz.) Sw species. The media was validated by five validatory with a CVI value of 0.96 and thus Biocard is not suitable for use as a learning media.
PERSEPSI SISWA TERHADAP PEMBELAJARAN BIOLOGI PADA KURIKULUM 2013 EDISI REVISI 2018
Authors: Irvandi Dede
Published: June 2022

To achieve the expected educational goals, a curriculum wass needed that can help the learning process run smoothly. The implementation of a curriculum would certainly had an impact on students, their perceptions on the perceptions of each student, especially in biology subjects. The aims of this study was determine students' perceptions in the biology learning process by teachers related to the applied curriculum. This study used a qualitative approach with a descriptive method which was a descriptive feature to describe the status of a phenomenon and was also a qualitative research, namely to see the perceptions of class XI students including teaching and learning activities that occur in the classroom. Observations show that SMA Negeri 2 Menyuke had implemented the use of the 2018 revised 2013 Curriculum which had four aspects of learning, namely Strengthening Character Education, Literacy, 4C (Communication, Critical Thinking, Creativity, and Collaboration), and HOTS (High Order Thinking Skill) which in total, students' perceptions of biology learning were 74.51% which was classified as good.
LiNi0.5Mn1.5O4 cathode microstructure for all-solid-state batteries
Authors: Lee Hyeon Jeong , Liu Xiaoxiao , Chart Yvonne , Tang Peng , Bae Jin-Gyu , Narayanan Sudarshan , Lee Ji Hoon , Potter Richard , Sun Yongming , Pasta Mauro
Published: June 2022

Solid-state batteries (SSB) have received increasing attention as a next-generation energy storage technology due to their potential in delivering superior energy density, power density and safety compared to commercial Li-ion batteries. One of the main challenges limiting their practical implementation is the rapid capacity decay caused by the loss of contact between cathode active material and solid electrolyte upon cycling. Here we use the promising high voltage, low-cost spinel LiNi0.5Mn1.5O4 (LNMO) as a model system to demonstrate the importance of the cathode microstructure in SSBs. We design Al2O3-coated LNMO particles with a hollow microstructure aimed at suppressing electrolyte decomposition, minimise volume change during cycling and shorten the Li-diffusion pathway to achieve maximum cathode utilisation and improve areal capacity. When cycled with a Li6PS5Cl solid electrolyte and a Li-In anode, we demonstrate capacity retention above 70% after 100 cycles with an active material loading of 27 mg/cm2 (2.2 mAh/cm2) at a current density of 0.8 mA/ cm2.
Learning Conductance: Gaussian Process Regression for Molecular Electronics
Authors: Deffner Michael , Weise Marc Philipp , Zhang Haitao , Mücke Maike , Proppe Jonny , Franco Ignacio , Herrmann Carmen
Published: June 2022

Experimental studies of charge transport through single molecules often rely on break junction setups, where molecular junctions are repeatedly formed and broken while measuring the conductance, leading to a statistical distribution of conductance values. Modeling this experimental situation and the resulting conductance histograms is challenging for theoretical methods, as computations need to capture structural changes in experiments, including the statistics of junction formation and rupture. This type of extensive structural sampling implies that even when evaluating conductance from computationally efficient electronic structure methods, which typically are of reduced accuracy, the evaluation of conductance histograms is too expensive to be a routine task. Highly accurate quantum transport computations are only computationally feasible for a few selected conformations and thus necessarily ignore the rich conformational space probed in experiments. To overcome these limitations, we investigate the potential of machine learning for modeling conductance histograms, in particular by Gaussian process regression. We show that by selecting specific structural parameters as features, Gaussian process regression can be used to efficiently predict the zero-bias conductance from molecular structures, reducing the computational cost of simulating conductance histograms by an order of magnitude. This enables the efficient calculation of conductance histograms even on the basis of computationally expensive first-principles approaches by effectively reducing the number of necessary charge transport calculations, paving the way towards their routine evaluation.
Reaction Dynamics within a Cluster Environment
Authors: Briant Marc , Mestdagh Jean-Michel , Gaveau Marc-André , Poisson Lionel
Published: June 2022

This perspective article reviews experimental and theoretical works where rare gas clusters and helium nanodroplet are used as nanoreactor to investigate chemical dynamics in a solvent environment. A historical perspective is presented first, then specific considerations on the mobility of reactants within these reaction media. The dynamical response of pure clusters and nanodroplets to photoexcitation is shortly reviewed before examining the role of the cluster (or nanodroplet) degrees of freedom on the photodynamics of the guest atoms and molecules.
Understanding water transport through graphene-based nanochannels via experimental control of slip length
Authors: Wen Xinyue , Foller Tobias , Jin Xiaoheng , Musso Tiziana , Kumar Priyank , Joshi Rakesh
Published: June 2022

The water transport along graphene-based nanochannels has gained significant interest. However, experimental access to the influence of defects and impurities on transport poses a critical knowledge gap. Here, we investigate the water transport of cation intercalated graphene oxide membranes. The cations act as water-attracting impurities on the channel walls. Via water transport experiments, we show that the slip length of the nanochannels decay exponentially with the hydrated diameter of the intercalated cations, confirming that water transport is governed by the interaction between water molecules and the impurities on the channel wall. The exponential decay of slip length approximates non-slip conditions. This offers experimental support for the use of the Hagen-Poiseuille equation in graphene-based nanochannels, which was previously only confirmed by simulations. Our study gives valuable feedback to theoretical predictions of the water transport along graphene-based channels with water-attracting impurities.
A Robust and Efficient Propane Dehydrogenation Catalyst from Unexpectedly Segregated Pt2Mn Nanoparticles
Authors: Rochlitz Lukas , Pessemesse Quentin , Fischer Jörg W. A. , Klose Daniel , Clark Adam H. , Plodinec Milivoj , Jeschke Gunnar , Payard Pierre-Adrien , Copéret Christophe
Published: June 2022

The increasing demand for short chain olefins like propene for plastics production and the availability of shale gas make the development of highly performing propane dehydrogenation (PDH) catalysts, robust towards industrially applied harsh regeneration conditions, a highly important field of research. A combination of surface organometallic chemistry (SOMC) and thermolytic molecular precursor (TMP) approach was used to prepare a nanometric, bimetallic Pt-Mn mate-rial (3 wt% Pt, 1.3 wt% Mn) supported on silica via consecutive grafting of a Mn and Pt precursor on surface OH groups present on the support surface, followed by a treatment under a H2 flow at high temperature. The material exhibits a 70% fraction of the overall Mn as MnII single sites on the support surface; the remaining Mn is incorporated in segregated Pt2Mn nanoparticles. The material shows great performance in PDH reaction with a low deactivation rate. In particular, it shows outstanding robustness during repeated regeneration cycles, with conversion and selectivity stabilizing at ca. 37% and 98%, respectively. Notably, a material with a lower Pt loading of only 0.05 wt% shows an outstanding catalytic per-formance – initial productivity of 4523 gC3H6/gPt h and an extremely low kd of 0.003 h-1 under a partial pressure of H2 – ranging among the highest reported productivities. A combined in situ XAS, STEM, EPR and metadynamics at the DFT level study could show that the strong interaction between the MnII decorated support and the unexpectedly segregated Pt2Mn particles is most likely responsible for the outstanding performance of the investigated materials.
Molecular Sonification for Molecule to Music Information Transfer
Authors: Mahjour Babak , Bench Jordan , Zhang Rui , Frazier Jared , CERNAK TIMOTHY
Published: June 2022

Organic chemical structures encode information about a molecule’s atom and bond arrangement. The most established way to encode a molecular structure is through line drawing, although other representations based on graphs, strings, one-hot encoded labels, or fingerprint arrays are critical to the computational study of molecules. Here we show that music is a highly dimensional information storage medium that can be used to encode molecular structure. The resultant method allows a molecular structure to be heard as a musical composition, where the key of the music is based on the molecular properties and the melody is based on the atom and bond arrangement. This allows for a molecular generation approach that leverages modern artificial intelligence tactics for music generation.
New insights into the kinetics of metal|electrolyte interphase growth in solid-state-batteries via an operando XPS analysis - part II: modelling
Authors: Williams Nicholas J. , Quérel Edouard , Seymour Ieuan D. , Skinner Stephen , Aguadero Ainara
Published: June 2022

Understanding the interfacial dynamics of batteries is crucial to control degradation and increase electrochemical performance and cycling life. If the chemical potential of a negative electrode material lies outside of the stability window of an electrolyte (either solid or liquid), a decomposition layer (interphase) will form at the interface. To better understand and control degradation at interfaces in batteries, theoretical models describing the rate of formation of these interphases are required. Yet, experimental data which could support these models are challenging to obtain considering that the decomposition reaction is dynamic in nature and occurs at a deeply buried interface making it inaccessible to quantitative non-destructive techniques such as X-ray photoelectron spectroscopy (XPS) which has a limited depth of analysis. In the first article of this two-parts study, an experiment was designed to study the formation of an interphase at the interface between a Na metal negative electrode and a NaSICON solid electrolyte (Na3.4Zr2Si2.4P0.6O12 or NZSP) using a recent XPS protocol. Data was collected operando as a Na metal layer was plated on top of the NZSP electrolyte inside the XPS chamber. It was demonstrated that an interphase forms at the Na0|NZSP interface but that a native Na3PO4 layer present on thermally activated NZSP samples can minimize the extent of decomposition. In this second article, it is demonstrated that the rate of plating and interphase formation at the Na0|NZSP interface can be accurately described by adapting the theory of coupled ion-electron transfer (CIET). Models are fitted using experimental data from the first part of this study (in particular, the peak positions and peak areas as a function of Na0 plating time). This second part of the study therefore highlights the depth of information which can be extracted from this single operando experiment.
Trends in Research and Development for CO2 Capture and Sequestration
Authors: Yu Xiang , Catanescu Carmen Otilia , Bird Robert , Satagopan Sriram , Baum Zachary J. , Zhou Qiongqiong Angela
Published: June 2022

Technological and medical advances over the past few decades epitomize human capabilities. However, the increased life expectancies and concomitant land-use changes have significantly contributed to the release of ~830 gigatons of CO2 into the atmosphere over the last three decades, an amount comparable to the prior two and a half centuries of CO2 emissions. The United Nations has adopted a pledge to achieve “net zero”, i.e., yearly removing as much CO2 from the atmosphere as the amount emitted due to human activities, by the year 2050. Attaining this goal will require a concerted effort by scientists, policy makers and industries all around the globe. Design of novel industrial-scale materials to selectively remove CO2 from other atmospheric gases has meant that it is now possible to adopt a multi-pronged approach towards atmospheric CO2 remediation. Broadly, the CO2 present in the atmosphere can be captured using materials and processes for biological, chemical, and geological technologies that can sequester CO2 while also reducing our dependence on fossil-fuel reserves. In this review, we used the curated literature available in the CAS Content Collection to present a systematic analysis of the various approaches taken by scientists and industrialists to restore carbon balance in the environment. Our analysis highlights the latest trends alongside the associated challenges.
Conformal efficiency as a metric for comparative model assessment befitting federated learning
Authors: Heyndrickx Wouter , Arany Adam , Simm Jaak , Pentina Anastasia , Sturm Noe , Humbeck Lina , Mervin Lewis , Zalewski Adam , Oldenhof Martijn , Schmidtke Peter , Friedrich Lukas , Loeb Regis , Afanasyeva Arina , Moreau Yves , Ceulemans Hugo
Published: June 2022

As training volume increases predictive model quality, leveraging existing external data sources holds the promise of time- and cost-efficiency. In a drug discovery setting, pharmaceutical companies all own substantial but confidential datasets. The MELLODDY project develops a privacy-preserving federated machine learning solution and deploys it at an unprecedented scale (more than 100,000 tasks across ten major pharmaceutical companies), while ensuring the security and privacy of each partner’s sensitive data. Each partner builds models that benefit from a shared representation, for their own private assays. Established predictive performance metrics such as AUC ROC or AUC PR are constrained to unseen labelled chemical space. However, they cannot gauge performance gains in unlabelled chemical space. Federated learning indirectly extends labelled space, but in a privacy-preserving context, a partner cannot use this label extension for performance assessment. Metrics that estimate uncertainty on a prediction can be calculated even where no label is known. Practically, the chemical space covered with predictions of sufficient confidence, reflects the applicability domain of a model. After establishing a link to established performance metrics, we propose the efficiency from the conformal prediction framework (‘conformal efficiency’) as a proxy to the applicability domain size. A documented extension of the applicability domain would qualify as a tangible benefit from federated learning. In interim assessments, MELLODDY partners report a median increase in conformal efficiency of the federated over the single-partner model of 5.5% (with increases up to 9.7%). Subject to distributional conditions, that efficiency increase can be directly interpreted as the expected increase in conformal i.e. high confidence predictions. In conclusion, we present the first evidence that privacy-preserving federated machine learning across massive drug-discovery datasets from ten pharma partners indeed extends the applicability domain of property prediction models.
Degradable linear and bottlebrush thioester-functional copolymers through atom transfer radical ring-opening copolymerization of a thionolactone
Authors: Nisa Qamar , Theobald William , Hepburn Kyle , Riddlestone Ian , Bingham Nathaniel , Kopec Maciek , Roth Peter
Published: June 2022

The radical thiocarbonyl addition–ring-opening (TARO) copolymerization of thionolactones with vinyl comonomers affords selectively degradable thioester functional polymers promising for biomedical applications. Herein, the use of atom transfer radical polymerization (ATRP) is investigated for the first time, using dibenzo[c,e]oxepane-5(7H)-thione (DOT), Cu(I)Br, and tris[2-(dimethylamino)ethyl]amine (Me6TREN) as thionolactone, catalyst, and ligand, respectively, with the acrylate comonomers poly(ethylene glycol) methyl ether acrylate (PEGA), methyl acrylate, benzyl acrylate, and butyl acrylate. Polymerizations were impeded by a side reaction, the Cu(I)-catalyzed dethionation of DOT to its (oxo)lactone analog, which caused the loss of up to 50 mol% of DOT in the early polymerization stages and limited the final copolymer DOT content. Nonetheless, readily degradable copolymers with low dispersities (1.10 ≤ Ð ≤ 1.26) were formed using DMSO, acetonitrile, or toluene as solvent. Presuming adventitious water to be the oxygen source, the dethionation side reaction could be minimized (≥ 5 mol-% lactone) by using anhydrous polymerization conditions, which enabled the synthesis of copolymers with higher DOT content. Exploiting documented advantages of ATRP over thermally-initiated RAFT polymerization in the synthesis of brushes, water-soluble molecular brushes were prepared by grafting PEGA–DOT copolymers from a pre-made multi-ATRP initiator. Due to faster incorporation of DOT, the cleavable thioesters were located close to the junctions and enabled the fast (< 1 min) oxidative cleavage of the arms from the core to give water-soluble products using 10 mM oxone. Expanding the scope of the ATRP and TARO methods, this work presents facile access to polymer materials with tailored architectures and degradability.
Impact of Tether Length and Flexibility on the Efficiency of Analyte Capture by Tethered Receptors
Authors: Beggiato Matteo , Dupont-Gillain Christine , Krishnamoorthy Sivashankar
Published: June 2022

Structure and functionality of molecular layers play a crucial role in determining the outcome of analyte-receptor interactions on affinity biosensors. The control over the structure of these molecular layers gives an independent means to enhance the sensor performance. Here we study the impact of the length and flexibility of molecular tethers on analyte capture by tethered receptors on quartz crystal microbalance and surface plasmon resonance sensors. Our results show clear enhancement of analyte-receptor interactions when receptors are bound to the sensor via flexible, and longer tethers. The findings further reveal a qualitative similarity of the impact of tether length on widely different type of binding interactions, viz. gold nanoparticle binding to tethered amine layers, and neutravidin binding to tethered biotin layers. By independent determination of tether densities, our investigations decouple the impact of receptor densities, and the tether conformations, and confirm the role of tether length on adsorption densities and kinetics. The results agree with theoretical reports in literature that predict enhanced analyte capture by receptors anchored to surface via long, flexible tethers, owing to enhanced freedom of movement and thereby its ability to “seek” the analyte in solution. These findings highlight the significance of factoring in the structure of the molecular tether to enhance analyte capture by tethered receptors, and thereby the performance of affinity biosensors.
Implementation of a cylindrical distribution function for the analysis of anisotropic molecular dynamics simulations.
Authors: Mandle Richard
Published: June 2022

The cylindrical distribution function (CDF) is a convenient anisotropic analogue of the radial distribution function, the difference being the use of cylindrical shells for binning. As such, CDF analysis can be a powerful tool for the analysis of positional correlations within anisotropic systems, such as liquid crystals. Here we describe a lightweight Python tool, cylindr, for the calculation of cylindrical distribution function, which is compatible with the output of a number of popular MD engines. We demonstrate the use of cylindr in computing the CDF of a number of exemplar materials: classical and ferroelectric nematics; lamellar and columnar liquid crystals.
A Cobalt Adduct of an N-hydroxy-piperidinium Cation
Authors: Anferov Sophie , Anderson John
Published: June 2022

Cooperativity between organic ligands and transition metals in H-atom (proton/electron) transfer catalysis has been an important recent area of investigation. Tetramethylpiperidine-N-oxyl (TEMPO) radicals feature prominently in this area, prompting us to examine cooperativity between its hydrogenated congener, TEMPOH, and Co centers ligated by dihydrazonopyrrole ligands which have previously been shown to also store H-atom equivalents. Addition of TEMPOH to (tBu,TolDHP)CoOTf results in the formation of an unusual Co-adduct of 1-hydroxy-2,2,6,6-tetramethylpiperidin-1-ium (TEMPOH2+) which has been characterized with IR spectroscopy and single crystal X-ray diffraction. This adduct is thermally unstable, and decomposes, putatively via N–O homolysis, to generate 2,2,6,6-tetramethylpiperidine and the Co-hydroxide complex [(tBu,TolDHP)CoOH][OTf]. Computational investigations suggest a proton-coupled electron transfer step to generate the TEMPOH2+ adduct where the Co center serves as an electron acceptor. Despite the prevalence of aminoxyl reagents in catalysis, particularly in aerobic transformations, metal complexes of differently hydrogenated congeners of TEMPO are rare. The isolation of a TEMPOH2+ adduct and investigations into its formation shed light on related transformations that may occur during metal-aminoxyl cooperative catalysis.
impact of COVID-19 pandemic and associated restrictions on skin cancer diagnosis and treatment in the western world
Authors: Bendayan Solomon , Lagacé François , Netchiporou Elena , Litvinov Ivan
Published: June 2022

No abstract for letter to editor as per author guidlines.
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Authors: Injeti Neelam
Published: June 2022

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Trabajabilidad del concreto con mezclas embolsadas y su influencia en la resistencia
Authors: Reymundo Gamarra Richard Hugo , Caller Pariona Sunlii K.
Published: June 2022

Nuevas tecnologías que permitan elevar la velocidad de construcción y durabilidad del concreto aparecen cada día y las dificultades de su uso son mayores, de aquí la necesidad de recurrir a un concreto con capacidad  de ser preparado en seco. Investigaciones preliminares certifican ventajas frente al concreto convencional en situaciones adversas como la lejanía y desabastecimiento de agregados.

En esta investigación, a fin de mejorar las propiedades del concreto embolsado UNICON y TOPEX, se ha variado la cantidad de agua por bolsa de concreto con el propósito de obtener una adecuada trabajabilidad, sin perjudicar la resistencia a compresión. La información obtenida podrá ser utilizada para elevar la productividad en la construcción de edificaciones.

La investigación fue experimental, se elaboró testigos de 4” y 8” para determinar la resistencia a la compresión (3, 7 y 28 días) y la trabajabilidad a través de su consistencia; para ello, se trabajó con dosis de agua diferentes: 3.5, 4.0, 4.5, 5.0 y 5.5 l/ bolsa. Se obtuvo, para 28 días, una resistencia de concreto 210 kg/cm² con 4.99 l/bolsa y asentamiento 7.19” para UNICON y con 4.41 l/bolsa y asentamiento 7.15” para TOPEX; una resistencia de concreto 175 kg/cm² con 5.25 l/bolsa y asentamiento 7.6” para UNICON y con 4.85 l/bolsa y asentamiento 8.1” para TOPEX; una resistencia de concreto 140 kg/cm² con 5.55 l/bolsa y asentamiento 8” para UNICON y con 5.2 l/bolsa y asentamiento 8.3” para TOPEX. Concluyendo que, a mayor cantidad de agua, mayor trabajabilidad, ligera segregación y menor resistencia a compresión
Dinámica de cambios de usos de suelo mediante agentes inteligentes y cadenas de Markov en el distrito de Huancayo
Authors: Arauco Esquivel Saúl , Huamán Samaniego Héctor , Soriano Córdova Gabriel
Published: June 2022

El cambio de usos del suelo en la ciudad de Huancayo se ha incrementado de manera descontrolada, debido a la migración de población rural a la ciudad, generando la formación de anillos concéntricos y desplazamiento del suelo agrícola para el desarrollo de otras actividades. El análisis del impacto de los cambios de uso de suelo en la zona rural – urbana de la ciudad de Huancayo se produce en la zona periurbana. Este trabajo de investigación se justifica porque ayuda a comprender el comportamiento del crecimiento urbano de la ciudad, mediante el uso de los agentes inteligentes y las cadenas de Markov.

El trabajo tiene como objetivo determinar la influencia de los cambios de usos de suelo en la distribución de las actividades sociales, económicas y comerciales en el distrito de Huancayo. El método de investigación es el Corine Land Cover, a partir de la teoría del crecimiento urbano se determina el cambio dinámico de uso de suelo. El cambio de uso de suelo de las vías aumenta en un 37 %, así mismo, se evidencia que el cambio de uso de suelo para el crecimiento urbano alcanzará un 19 % y 16 % de disminución del suelo agrícola.
Pérdida de carga en un sistema de tuberías de agua: comparación de resultados experimentales mediante el equipo HM 150.61
Authors: De La Cruz Lezama Marcial , Delzo Salomé Armando Siles , Jacobi Lorenzo Ronald , Mattos Inga Carlos Pedro
Published: June 2022

El trabajo consistió en comparar los resultados de pérdida de carga obtenidos de manera experimental mediante el equipo HM 150.61, en un sistema de tuberías de agua. La medición de los datos primigenios se realizó con los instrumentos artesanales y el cálculo en una hoja de cálculo Excel, y para la medición electrónica se utilizó el equipo HM 150.61 que cuenta con sensores de medición, proveído por la empresa Gunt Hamburg.

El objetivo principal fue determinar la desviación entre la medición experimental y electrónica, pudiendo evidenciar que existe poca desviación; y se comprobó la efectividad de dicho equipo como medio de aprendizaje para los estudiantes de ingeniería y carreras afines; también la medición con el equipo y los resultados experimentales muestran la efectividad de combinar los dos métodos para medir y estimar las pérdidas de carga y poder tomar decisiones mucho más acertadas a la hora de ejecutar proyectos de  redes de distribución de agua potable. Se determina el comportamiento de la curva de pérdida de carga, para calcular la potencia de bomba necesaria para hacer circular el agua en un sistema de tuberías.
Pretratamiento ácido de residuos de Apio (Apium Graveolens)
Authors: Eufracio Arias Wilder E. , Sanabria Pérez Elías A.
Published: June 2022

En la investigación se determinó la influencia del tiempo, temperatura y dosis de H2SO4 en las características de la celulosa y concentración de glucosa en el pretratamiento ácido de los residuos de apio, de tal manera que los residuos de apio pretratados tengas las mejores condiciones para la hidrólisis y posterior fermentación, y tener como producto final etanol. La parte experimental consistió en colectar y preparar los residuos de apio, preparar el reactivo DNS y elaborar la curva de calibración de la glucosa que sirve para determinar la concentración de azucares reductores, realizar el pretratamiento ácido a 25 g de residuos en cada experimento y determinar la morfología de la celulosa con el microscopio de barrido electrónico (SEM) Mira 3 Tescan. Las variables que se evaluó son la concentración del H2SO4 (0.1%, 2.5% y 4.0%), temperatura (60, 70 y 80 °C) y tiempo (2, 3 y 4 horas) y se siguió las experimentaciones del diseño experimental. De las pruebas iniciales, los niveles bajos de las variables son las mejores condiciones del pretratamiento ácido por la morfología que presentan que concuerdan con lo indicado en la literatura, con ello la producción de glucosa en la hidrólisis será mayor y etanol en la fermentación.
Prototipado Bootstrapping y adaptabilidad disruptiva para el desarrollo de un parque científico tecnológico de tercera generación
Authors: Porras Rojas Javier Eduardo , Carrera Cabezas Diego
Published: June 2022

La presente investigación tiene como objetivo principal determinar cómo incide el prototipado bootstrapping en el desarrollo del parque científico tecnológico de tercera generación de la Universidad Nacional del Centro del Perú (UNCP). Con un enfoque para la adaptación de materiales en la resolución de problemas y el uso del diseño sobre criterios múltiples. La investigación se encuentra en la interfaz entre territorio, arquitectura, biología e informática y aborda la complejidad, la sostenibilidad y desafíos de innovación en el diseño e ingeniería de materiales y entornos. El Proyecto se inserta dentro del ámbito de una ciudad-territorio (CT) y en esta se hace aplicativo, vía materia mediada, el desarrollo de un Parque Científico y Tecnológico (PCT) de tercera generación, haciendo evidente la relación estratégica de PCT-CT, inmerso en una modelación generativa de Inteligencia Territorial (IT), situación que faculta la gestión pertinente y eficaz a través del uso de herramientas Delivery Unit y/o CitiStat, que validan el I+D+I, de la UNCP, la red de PYMEs situadas dentro de Selva Central y de la misma CT, que constituyen los actores y grupos de interés a ser captados como inminentes integrantes del PCT y de otro lado recoger las experiencias de cuatro estratégicos PCTs de Cataluña-España (PCTs: UPC, UB, UAB, Lleida, se cuenta con un convenio inicial específico con la Universitat Politècnica de Catalunya).
Parámetros limnológicos y productividad piscícola para la piscicultura de trucha arco iris en lagunas altoandinas - Junín, Perú
Authors: Chanamé Zapata Fernán , Poma Chávez Christian
Published: June 2022

Se evaluaron los parámetros limnológicos determinantes de la productividad piscícola para la piscicultura de la trucha arco iris en lagunas altoandinas, Junín - Perú. Se consideraron tres sectores de muestreo en cada una de las tres lagunas, Habascocha, Huascacocha y Pomacocha; en los cuales, se recolectaron 36 muestras de agua. Las muestras se recolectaron directamente de las lagunas en cada uno de los sectores de muestreo, en envases de vidrio de 750 mL. La temperatura del agua, oxígeno, dióxido de carbono, alcalinidad, dureza y pH, fueron determinados in situ, mientras que los nitritos, nitratos, fosfatos y los parámetros biológicos como fitoplancton, zooplancton, vegetación acuática, necton, bentos, fueron analizados en el Laboratorio de Análisis de aguas de la UNCP. Se determinó la productividad piscícola teórica, de las lagunas, previo cálculo de su capacidad biogénica en función a las características físicas, químicas y biológicas, predominantes en el ambiente acuático y el coeficiente de productividad, así como la capacidad de carga inicial con la productividad anual (kg), el área a utilizar y la capacidad biogénica de cada laguna. Los resultados obtenidos demuestran que, los parámetros limnológicos cumplen con los requerimientos ambientales para la piscicultura de la trucha arco iris, en diferentes sistemas de producción en lagunas altoandinas. Presentan una capacidad biogénica de IV, siendo aguas de una productividad piscícola media. La productividad piscícola de manera extensiva para las lagunas, Habascocha, Huascacocha es de 245.56, 264.72 y 239.85 kilogramos por año, respectivamente, la cual resulta adecuada para la producción de truchas en jaulas flotantes.
Desarrollo económico y social en el Perú en el contexto de la crisis sanitaria del COVID-19 y en el marco del bicentenario de la República
Authors: Serruto Castillo Alison , Rivera Flores Víctor Alfonso , Sana Chalco Fiorela Luz , Zanabria Cabrera Luis Carlo
Published: June 2022

El Perú se ubica entre los países que peor ha manejado la pandemia a nivel mundial, demostrando su alta vulnerabilidad, así como las profundas contradicciones socioeconómicas acentuadas por el modelo económico neoliberal aplicado desde los años noventa hasta la actualidad. En tanto, para el presente artículo se tiene como objetivo analizar el desarrollo económico y social en el Perú en el contexto de la crisis sanitaria del COVID-19 y en el marco del bicentenario de la República. Para lo cual se utilizó como metodología la revisión documental de artículos científicos y revisión estadística de las principales plataformas públicas virtuales: INEI, ENAHO, MEF, MINEDU, MINSA y otros. Entre los resultados se tiene que el Perú ha tenido un crecimiento económico positivo ininterrumpido desde 2005 al 2015, la pobreza fue disminuyendo un -1.8% en promedio desde el 2009 al 2016, el 2017 aumento un 1%, los siguientes años antes de la pandemia solo disminuyo en - 0.8%, aumentado en 9.9 % el año 2020. En cuanto al empleo se destaca que el 67.7% es informal, y en educación el -4.4% de estudiantes entre 3 a 16 años no pudieron acceder a las clases escolares, este mismo año solo se ejecutó el 69.1% del presupuesto destinado a salud. Se concluye que el crecimiento económico no tuvo resultados sostenibles en los indicadores sociales y económicos del presente estudio, puesto que en todos se observa debilidades y son más notorios en esta crisis sanitaria.
Factores familiares que inciden en la calidad de vida de adultos mayores durante la pandemia en El Tambo – Ecuador
Authors: Paucar Muñoz Diana Esther , Urgilés León Sandra Jackeline , Fernández Aucapiña Nancy Yolanda
Published: June 2022

Las personas adultas mayores constituyen la población más vulnerable en épocas de pandemia por sus situaciones fisiológicos y psicológicos por ello: Determinar los factores familiares que inciden en la calidad de vida de adultos mayores en época de pandemia en la Comunidad de Jalupata, del Cantón El Tambo – Ecuador, fue el objetivo de investigación cumplido mediante un diseño cuantitativo de tipo descriptivo aplicado a una muestra de 40 PAM y 40 de sus familiares; con dos escalas se recolectó información la cual fue tabulada y analizada para obtener resultaros que mostraron correlación e incidencia entre la variable independiente factores familiares en dimensiones de derechos del adulto mayor, convivencia familiar y vínculos afectivos con la variable dependiente calidad de vida de PAM. En un rango de nivel medio o moderado, existe incidencia de parte de cada una de las dimensiones de la variable factores familiares sobre la variable calidad de vida, pero no todos los factores analizados presentan una relación con los indicadores y dimensiones de la variable dependiente, esto es lógico ya que en mayor o menor medida existen factores familiares que serán aplicados por unas familias y en otras no. Se concluyó que entre los factores familiares que inciden están la protección familiar, contribuir económicamente, integrar adultos mayores dentro de reuniones espirituales, laborales, contribuir a satisfacer necesidades básicas, brindar cuidados de salud física, mental, visitarlos, generar acciones de apego. Los factores que inciden negativamente son el maltrato físico y psicológico sobre la presencia de enfermedades, la integración y salud psicoemocional.
Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension
Authors: Florentin Jonathan , Zhao Jingsi , Tai Yi-Yin , Sun Wei , Ohayon Lee L , O’Neil Scott P , Arunkumar Anagha , Zhang Xinyi , Zhu Jianhui , Al Aaraj Yassmin , Watson Annie , Sembrat John , Rojas Mauricio , Chan Stephen Y , Dutta Partha
Published: June 2022

Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure, leading to right ventricular failure and death. Pathogenic features of PH include endothelial apoptosis and vascular inflammation, which drive vascular remodeling and increased pulmonary arterial pressure. Re-analysis of the whole transcriptome sequencing comparing human pulmonary arterial endothelial cells (PAECs) isolated from PH and control patients identifiedAREG, which encodes Amphiregulin, as a key endothelial survival factor. PAECs from PH patients and mice exhibited down-regulation ofAREGand its receptor epidermal growth factor receptor (EGFR). Moreover, the deficiency ofAREGandEGFRin ECs in vivo and in vitro heightened inflammatory leukocyte recruitment, cytokine production, and endothelial apoptosis, as well as diminished angiogenesis. Correspondingly, hypoxic mice lackingEgfrin ECs (cdh5cre/+Egfrfl/fl) displayed elevated RVSP and pulmonary remodeling. Computational analysis identifiedNCOA6,PHB2, andRRP1Bas putative genes regulatingAREGin endothelial cells. The master transcription factor of hypoxia HIF-1⍺ binds to the promoter regions of these genes and up-regulates their expression in hypoxia. Silencing of these genes in cultured PAECs decreased inflammation and apoptosis, and increased angiogenesis in hypoxic conditions. Our pathway analysis and gene silencing experiments revealed that BCL2-associated agonist of cell death (BAD) is a downstream mediator ofAREG.BADsilencing in ECs lackingAREGmitigated inflammation and apoptosis, and suppressed tube formation. In conclusion, loss of Amphiregulin and its receptor EGFR in PH is a crucial step in the pathogenesis of PH, promoting pulmonary endothelial cell death, influx of inflammatory myeloid cells, and vascular remodeling.
Psychosomatic Medicine in the Context of Theological Reflection
Authors:   Russian Academy National Economy and Public Administration, Damte D. S. ,   Russian Orthodox University of Saint John the Divine
Published: June 2022

The article provides a comparative analysis of the notions of man, illness, health and treatment in psychosomatic medicine and in theological anthropology. This topic seems relevant in the context of exploring a wide range of issues related to the dialogue between theology and modern human sciences. Various materials show similarities between the anthropological approaches presented in the works of psychosomatic theorists and in theological anthropology, which makes possible an interaction between them that expands and deepens knowledge about human beings, their problems and possible ways of solving them.
Socio-political Guidelines of the Religious Community of Modern Russia in the Context of Ensuring National Security
Authors:   Saratov State Law Academy, Slobozhnikova V. S.
Published: June 2022

The guidelines of the socio-political practices of the religious world of modern Russia are considered in the context of the tasks formulated in the National Security Strategy adopted in 2021. The author identifies the areas of security to which the religious community can make a serious contribution: human potential development; maintenance of civil peace and harmony in the country, development of mechanisms of interaction between the state and civil society; protection of traditional Russian spiritual and moral values, culture and historical memory. The problems of the activity of the religious world in these areas are presented, attention is focused on the formation of the civic identity of Russians within the framework of secular state-confessional relations.
Chinese-American Relations and Problem of Taiwan
Authors:   Irkutsk State University, Puzynya N. N.
Published: June 2022

The problems of Chinese-American relations over the course of fifty years since the establishment of the first contacts, related to the solution of the Taiwan issue, which, according to the official representatives of the PRC, is a key one in bilateral relations, are considered. The evolution and reasons for the change in the approaches of the Chinese and American sides to solving this problem are analyzed. In conclusion, it is indicated that in modern conditions, taking into account various circumstances, both objective and subjective, such a development of events that can dramatically change the state of modern Sino-American relations is not excluded.