bluuebunny/crossref_metadata_2025 huggingface dataset:
Meta-analysis of HNF1A-MODY3 Variants Among Human Population
Authors: Behl Rachna , Malhotra Nishtha , Joshi Vinay , Poojary Shruti , Middha Sanniya , Gupta Shalini , Olaonipekun Arinola B. , Okoye Ikechukwu , Wagh Bhushan , Biswas Dibyendu , Aginah Chukwuemelie , Saini Bhavya , Nwanya Chinaza , Ugwu Sopuluchukwu , Modupe Anthony , Fang Xuanyu S. , Ogunfile Foluso , Ibrahim Abdulrahman Tudu
Published: December 2021

BackgroundPreviously, numerous case-control studies have highlighted variants responsible for Maturity onset diabetes of young (MODY). However, these studies have been conducted among diverse populations and hence yielded contradictory results. We, therefore, performed a meta-analysis to precisely find the association of SNPs with the disease for the HNF1A gene.ObjectiveMeta-analysis of clinically defined studies deciphering mutations in the HNF1A gene responsible for the development of MODY3 was conducted among various populations to determine associations using statistical approaches. MethodsThe curation of 505 research articles published between the years 2000-2021 was carried out. Visualization of data-related protocols and statistical-analysis were conducted, which led to the identification of highly prevalent mutations among different populations (majorly Europe). Further comparison between the frequencies of the control (healthy population) and test (diseased population) dataset generated through curation was performed.ResultsWe identified nine MODY3 mutations (rs587776825, rs1169288, rs1800574, rs2464196, rs137853244, rs137853238, rs587780357, rs137853240 and rs137853243) at the genome-wide significance level (p<5.0×10–8). The present study confirmed that the data does not follow a normal distribution. Further, the data was confirmed to be a more homogenous type with frequencies having a significant association with the disease.Conclusion﻿This meta-analysis found significant associations of mutations in HNF1A with MODY3, consistent with previous studies. Our findings should help elucidate the mutations in a compiled form responsible for causing MODY3.
Development of Critical Thinking Transfer Practice Construct and Sub-Constructs: A 9-steps Approach
Authors:   Faculty of Medicine and Health Sciences, Universiti Sains Islam Malaysia, Negeri Sembilan, Malaysia, Mat Said Noor Azura ,   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia, Bujang Siti Mariam ,   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia, Buang Nor Aishah ,   Centre of STEM Enculturation, Faculty of Education, Universiti Kebangsaan Malaysia, Selangor, Malaysia, Awang Besar Mohd Nasri ,   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia, Siraj @ Ramli Harlina Halizah ,   Department of Medical Education, Faculty of Medicine, Universiti Kebangsaan Malaysia, Selangor, Malaysia
Published: December 2021

The study aimed to develop critical thinking transfer practice (CTTP) construct and sub-constructs relevant to medical undergraduates. The study used a 9-step qualitative case study approach. The prior relationship of construct and sub-constructs were conceptualised to produce the initial thematic framework (Step 1 to 3). Then, a qualitative study confirmed the sub-constructs that were relevant for the undergraduates, as the new data were fitted into the initial framework to become an evolving framework (Step 4 to 5). Next, the construct and sub-constructs were defined operationally (Step 6) and evaluated (Step 7). After that, the evolving framework was revised (Step 8) and developed to become the final construct and sub-constructs (Step 9). Based on the literature, the study conceptualised an initial framework that described the theoretical relationship of the prior construct and six sub-constructs. From the qualitative findings, 37 codes were fitted into the initial framework. The fitting resulted in an evolving framework that contained a theme (the medical undergraduates’ CTTP), 6 categories and 26 sub-categories. A 100% of participants agreed that the data were generated from them. Then, the team members and the expert panels accepted the theme (Cohen Kappa value > 0.80). The maintained and revised theme, categories and sub-categories were used to develop the CTTP construct and 6 sub-constructs. The study discussed in detail the included subconstructs for CTTP. The study also addressed the similarities and differences of the construct and sub-constructs for medical education and general studies. The study concluded that the construct and sub-constructs were theoretically proven to represent the medical undergraduates’ CTTP.
LEADERSHIP SCOLAIRE DURANT LA PANDEMIE DE COVID-19
Authors:   Doctorant Au CEDOc : Homme-Societe-Education Filiere : Analyse et Evaluation Des Systeme dEducation Et De Formation Faculte Des Sciences De lEducation Universite Mohammed V De Rabat., Aissi Soufyane EL
Published: December 2021

Alors que la pandemie de COVID-19 se propageait rapidement a travers le monde, de nombreuses ecoles ont eu du mal a reagir a la fois rapidement et de maniere adequate. Les ecoles sont parmi les institutions societales les plus importantes impactees par la pandemie. Cependant, la plupart des chefs detablissement nont que peu ou pas de formation de gestion de crise, et nont jamais eu a gerer une crise de cette ampleur et de cette portee pendant aussi longtemps. Cet article met laccent sur la vision et les valeurs, la communication et lengagement des familles et de la communaute, lorientation scolaire, les pratiques de leadership axees sur lequite et la reconnaissance des opportunites futures.
CLINICAL PROCEDURE OF IMMEDIATE DENTIN SEALING FOR INDIRECT BONDED RESTORATION
Authors:   PG Student, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India., P. Gurjar Pawan , Vachhani Kiran ,   Professor, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India., Attur Kailash ,   Head of Department &Professor, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India., D. Soni Switibahen ,   PG Student, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India., P. Joshi Vishwesh ,   PG Student, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India., Panchal Akshita ,   PG Student, Department of Conservative Dentistry and Endodontics, Narsinhbhai Patel Dental College and Hospital, Visnagar, Gujarat, India.
Published: December 2021

Immediate Dentin Sealing or pre-hybridization implies the application of resin adhesive to freshly cut dentin after teeth preparation, before impression. Immediate Dentin Sealing has been suggested as an alternative to the delayed dentin sealing (DDS), a technique in which resin adhesive is applied just before final bonding of indirect restorations. Immediate Dentin Sealing technique is universal i.e used in inlays, onlays, veneers, crowns and well documented clinically and experimentally. Various types of Dentin Bonding Agents are available on the market. Difference lies in the thickness of hybrid layer formed and the adhesive used.
NATURAL PRODUCTS WITH ANTI-HERPES ACTIVITIES: IN VIVO STUDIES
Authors:   Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq., Sabry Al-Atbi Hala , B. Sabti Asmaa ,   Department of Chemistry, College of Science, University of Misan, Maysan, Iraq., A. Ali Sahar ,   Department of Chemistry, College of Science, University of Basrah, Basrah, Iraq.
Published: December 2021

Herpes are a group of similar viruses that are responsible for a number of infecting diseases, the most important of which are herpes simplex, herpes zoster and pseudopox. Resistance to traditional antiviral medications is becoming increasingly common, making treatment of such infections even more difficult. For example, the usage of nucleoside analogues like acyclovir to target the DNA-polymerase of the virus on a regular and long-term basis promotes the generation of resistant viruses. As a result, a different treatment is required. Natural products, such as herbal remedies, have been shown to have in vitro and in vivo activity against herpes viruses, and have shown to be a valuable source for new antivirals development and separation. The goal of this review is to highlight the most promising extracts and pure chemicals obtained from plants and marine species that have in vivo anti-herpes simplex virus (HSV-1 and HSV-2) action. Natural products as new anti-HSV medications offer a number of benefits, including fewer side effects, minimal toxicity, and lowered resistance, and a variety ways of deed.
DIGITAL OCCLUSAL ANALYSIS AND ORAL HEALTH-RELATED QUALITY OF LIFE OF PATIENTS WITH 3D PRINTED COMPLETE DENTURES VERSUS CONVENTIONAL DENTURES
Authors:   Fixed and Removable Prosthodontics Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt., S.El Gabry Hisham , M. Eissa Sherihan ,   Fixed and Removable Prosthodontics Department, Oral and Dental Research Institute, National Research Centre, Cairo, Egypt., A. Abuheikal Mohamed ,   Removable Prosthodontics Department, MSA University, Cairo, Egypt.
Published: December 2021

Background: 3D printed complete dentures fabrication with computer-aided designing and computer-aided manufacturing (CAD/CAM) techniques is becoming popular nowadays. However, studies that analyzed the occlusal forces distribution using recent digital methods as T-scan III and further evaluated the dentures effect on patient`s life quality were lacking. Objectives: Evaluation of the occlusal forces distribution using T-scan III, and evaluation of the oral health-related quality of life (OHRQoL) using Oral Health Impact Profile for Edentulous Patients (OHIP-EDEN) questionnaire for 3D printed complete dentures and comparing it with conventional denture fabrication techniques. Methods: Twenty completely edentulous patients were selected and divided randomly into two equal groups according to manufacturing technique group I (patients who received conventional complete dentures), and group II (patients who received 3D printed complete dentures). For all patients, occlusal force analysis (percentage of applied occlusal force on both sides) was performed using the T-Scan III (digital occlusal analysis system). Also, OHRQoL was assessed using (OHIP-EDENT) questionnaire. Results: In the digital occlusal analysis, comparison between right and left sides regarding occlusal forces distribution revealed a significant difference in group I (conventional denture), while in group II (3D printed denture), it revealed an insignificant difference. Regarding, OHIP-EDENT patients in group I (conventional denture) revealed higher scores than group II (3D printed dentures). Also, the correlation between occlusal forces & (OHIP-EDENT) scores revealed a strong negative significant correlation. Conclusions: The 3D printed complete dentures fabricated using CAD/CAM technology proved to be more superior over conventional methods in terms of digital occlusal force analysis and Oral Health Impact Profile for Edentulous Patients (OHIP-EDENT). However, further studies are required on more patients to decide the exact superiority of one technique over the other after long-term follow-up periods.
SIGNIFICANCE OF FORESTS IN TRIBAL VERNACULAR ARCHITECTURE: IN CONTEXT TO KHARIA TRIBE IN JHARKHAND,INDIA
Authors: Saumya Shruti
Published: December 2021

Tribal community and their association with nature is deeply rooted. The primitive tribes in India and the world are settled around forests or islands and use their products for their livelihood. The style of architecture, art, culture, beliefs, socio-economic framework is guided by the local environment. As the primitive tribe remain secluded from the urban development and advancement, their beliefs and practices are limited and are based on real time experiences. The availability of resources around the community shapes the type of architectural and cultural practices of the tribe. The forest provides ample resources like wood, fodder, mud, straw, etc. which serves as construction materials, fuel, and source of livelihood for the ethnic community. The article throws light on the influence of forests and its resourceson the vernacular architectural style, the settlement pattern, dwelling units, construction technology and, materials which ultimately responds to the local climate, art, culture, socio-economic framework, and beliefs of the people.
A CASE REPORT OF APLASIA CUTIS CONGENITA TYPE VI: BART'S SYNDROME
Authors:   Faculty of Medicine, Department of Basic Medical Science, Salaam University, Mogadishu, Somalia., Mead Ahmed , Alem Yordanos ,   College of Heath Science, School of Medicine, Addis Ababa University, Addis Ababa, Ethiopia., Adam Sheikh Omar ,   Faculty of Medicine, Department of Basic Medical Science, Somali National University, Mogadishu, Somalia., Ibrahim Hussein Layla ,   Banadir Maternity and Children Hospital, Mogadishu, Somalia.
Published: December 2021

Aplasia cutis congenita type VI (Barts syndrome), is a rare genetic disorder characterized by congenital localized absence of skin, formation of blisters (epidermolysisbullosa), and nail abnormalities. In this report, we present a rare case of aplasia cutis congenita type VI (Barts syndrome) in a newborn malebaby with the absence of a skin layer over the anterior right leg, slightly below the patella (kneecap) and around the ankle joint.On the second day, the affected areas developed blisters characterizing epidermolysisbullosa.Laboratory investigationswere all normal. The patients wound was managed conservatively with dressing and topical antibiotic ointments.
OCULAR CLINICAL PROFILE OF PATIENTS WITH PSEUDOEXFOLIATION SYNDROME AND PSEUDOEXFOLIATION GLAUCOMA AT TERTIARY CARE CENTRE IN KASHMIR
Authors:   Postgraduate Scholar, Department of Ophthalmology, GMC Srinagar., Bashir Jasiya , Akbar Wani Ejaz ,   Associate Professor, Department of Ophthalmology, GMC Srinagar.
Published: December 2021

Aim: To study the clinical profile of pseudoexfoliation (PEX) syndrome and Pseudoexfoliation glaucoma at tertiary care centre in Kashmir. Materials and Methods: A cross sectional study consisting of 100 PEX and 100 PEXG patiens, attending the general ophthalmology clinic of a tertiary care center in kashmir. All patients underwent a complete ophthalmologic evaluation including recording IOP,gonioscopy and Central Corneal Thickness(CCT). Results: The study cohort comprised 200 patients(100 with PEX and 100 with PEXG). There were 145(72.5) males and 55(27.5%) females. The highest number of patients (120 patients) were from the age group between 61 and 70years. 145(72.5%) patients were involved in outdoor activities.153(76.5%) patients had bilateral involvement of pseudoexfoliationand pseudoexfoliative material was present at anterior lens capsule in 175(49.58%) eyes. Nuclear cataract was predominant type of cataract and was present in 188(48.2%)eyes. Mean IOP was 17.26Â±7.634mmHg in PEX group and 24.39Â±4.456mmHg in PEXG group. Gonioscopyshowed open angles in 96.5% of eyes and occludable in 3.5% eyes . Mean central corneal thickness was 531.80Â±19.127Î¼m. Conclusion: The prevalence of PEX is found to increase with age. Patients with PXG had more severity of optic nerve damage at presentation. Therefore a careful assessment for detection of PEX is warranted and regular follow-up of patients is desired to minimize the extent of optic nerve damage.
Adaptability of F1 sunflower hybrids, created according to an integrated system of line selection for economically valuable traits in various agroclimatic zones
Authors: Babych V. O. , Borovska I. Yu. , Sharypina Ya. Yu. , Parii Ya. F. , Symonenko Yu. V.
Published: December 2021

Purpose. Determine the ecological plasticity and productivity of F1 sunflower hybrids created on the basis of maternal and parental lines, selected according to an accelerated selection system of lines resistant to herbicides (imidazoline and sulfonylurea groups) and broomrape (Orobanche cumana Wallr.).
Methods. Statistical analysis of F1 sunflower hybrids was carried out using the methods of variation statistics, regression and analysis of variance using the Microsoft Office Excel 2016 application package. Molecular biological, biotechnological and classical selection methods were used for the accelerated system of line selection. Thus, for the purpose of targeted selection of sunflower sterility fixers, we used HRG01 molecular SCAR marker to identify the gene for the restoration of pollen fertility (Rf1). To accelerate the creation of parental lines resistant to tribenuron-methyl, we used a culture of immature embryos in vitro.
Results. The results of testing of F1 sunflower hybrids at Kyiv, Chernihiv, Cherkasy (Uman and Shpolianskyi districts), Khmelnytskyi, Kharkiv, Kherson and Odesa regions. The hybrids were created on the basis of selected lines, chosen according to an accelerated selection system for herbicide-resistant lines (imidazoline (IMI-hybrids) and sulfonylurea (SU-hybrids) groups) and broomrape (Orobanche cumana Wall). The standards for comparison with hybrids were: for IMI hybrids – hybrids ‘NK Neoma’ (Syngenta) and ‘ES Genesis’ (Euralis), and for SU-hybrids – ‘SY Sumiko’ (Syngenta) and ‘P64LE25’ (Pioneer). As a result, it was found that among SU-hybrids, UA 2/106 had a 3.9% higher yield when compared to the standards (‘SY Sumiko’ and ‘P64LE25’). And for IMI-hybrids it was found that hybrids UA 1/67, UA 1/66, UA 1/84 have the same yield of 2.76 t/ha as the ‘NK Neoma’ standard. IMI hybrids UA 1/92, UA 1/102 have the same yield of 2.91 t/ha as ‘ES Genesis’.
Conclusions. F1 hybrids were created on the basis of the original breeding material selected due to the accelerated system of sunflower lines selection. The hybrids were analyzed according to the yield indicator. The most productive among the tested SU-hybrids was UA 2/106 hybrid, among the IMI hybrids – UA 1/67, UA 1/66, UA 1/84, UA 1/92 and UA 1/102.
Amino acid content in grain of different winter pea varieties and products of its processing
Authors: Voitovska V.I. , Storozhyk L.I. , Liubych V.V. , Romanov S.M.
Published: December 2021

Purpose. Determine amino acid content, biological and nutritional value of grain of different winter pea varieties and products of its processing.
Methods. The amino acid share was determined by ion exchange liquid chromatography. Mathematical processing of the obtained data was performed by variance analysis of a one-factor field experiment. Amino acid and integral scores were determined by calculation.
Results. Winter pea grain of ‘NS Moroz’, ‘Baltrap’ and ‘Enduro’ varieties had high amino acid content. In the composition of essential amino acids, lysine and leucine share was the highest – 1.53–1.77%, and methionine share was the lowest – 0.25–0.28% depending on winter pea variety. The main amino acid of winter pea grain was glutamic acid, the share of which was 3.25–3.30% of the share of all amino acids. The share of aspartic acid was 2.30–2.37% depending on the variety. In the composition of essential amino acids, cystine share was the lowest – 0.31–0.37% depending on the variety. The share of essential amino acids in winter pea was 40–41% of their total. The share of tryptophan decreased by 30–43%, isoleucine – by 20–24%, methionine – by 8–29%, phenylalanine, lysine, leucine – by 8–12%, valine share – by 5–9%, threonine one – by 1–5%. In the composition of essential amino acids, cystine share decreased most – by 58–73%, histidine – by 36–43%, glycine – by 42–45% compared to grain. Alanine share decreased by 19–25%, glutamic acid – by 12–15%, tyrosine – by 8–18%, aspartic acid – by 9–12%. The share of serine and arginine decreased least of all – by 3–8%. However, the amount of essential amino acids decreased by only 15–17% depending on the varietal cha­racteristics. It was found that the amino acid score of winter pea grain and products of its processing was non-deficient. Calculations showed that 100 g of winter pea grain satisfied the biological need of adults with isoleucine by 55–58%, valine – 51–42%, tryptophan – 41–50%, lysine – 37–40%, threonine – 39–40%, leucine – 36–38%. The highest daily requirement was provided by 100 g of grain processing products with arginine and glutamic acid – by 20–26%, depending on winter pea variety. For the rest of the essential amino acids, this figure was 6–16% for flour and 2–15% for cereals due to a decrease in the amino acid content in these products.
Conclusions. The share of amino acids, biological and nutritional value of grain of different winter pea varieties and products of its processing, such as cereals and flour were determined. In the amino acid composition, the share of essential amino acids predominated, but 100 g of grain and products of its processing most meet the need for essential amino acids. The share of amino acids is reduced in the products of winter pea processing, especially in cereals. The amino acid score of winter pea grain of ‘NS Moroz’, ‘Baltrap’ and ‘Enduro’ varieties and products of its processing was balanced.
Level of manifestation and variability of grain number per spike in spring barley
Authors: Hudzenko V. M. , Polishchuk T. P. , Lysenko A. A. , Khudolii L. V. , Babenko A. I. , Mandrovska S. M.
Published: December 2021

Purpose. To identify features of the level of manifestation and variability of grain number per spike in spring barley and reveal new genetic sources by combining increased and stable level of manifestation of the trait for breeding in the central part of the Forest-Steppe of Ukraine.
Methods. The research was conducted in 2018–2020 under conditions of the V. M. Remeslo Myronivka Institute of Wheat of NAAS. We studied 96 collection accessions of different subspecies and groups of spring barley varieties originating from 15 countries. A number of statistical parameters and graphical models were used.
Results. The ANOVA of the AMMI model revealed significantly higher part of contribution in the total phenotypic variation for every its component: growing season conditions (33.8–40.2%), genotype (35.2–48.9%), and genotype – environment interaction (17.3–29.3%). According to the homeostaticity (Homi) and breeding value (Sci) levels and GGE biplot visualizations, the samples were differentiated by the level of manifestation and variability of the trait and new genetic sources for barley breeding were identified. The coefficient of phenotypic variation ranged from low in two-rowed hulled samples (PCV = 9.60%) to near-high in hulless ones (PCV = 18.9%). High values of the coefficient of genotypic variation were found in hulless (GCV = 10.95%) and six-rowed samples (GCV = 13.28%). The coefficient of heritability of the trait varied from high (H2 = 79.4%) in two-rowed samples to near-low (H2 = 33.7%) in six-rowed samples. The expected genetic improvement ranged from middle in multi-row samples (GAM = 13.10%) to high in hulless samples (GAM = 23.51%).
Conclusions. Collection accessions combining increased grain number and its relative stability were identified, namely, two-rowed hulled ones ‘Tiver’ (UKR), ‘Almonte’ (CAN), ‘Despina’ (DEU), ‘Symbat’ (KAZ), ‘Smaragd’ (UKR), ‘Novator’ (UKR); two-rowed hulless ones ‘CDC Candle’ (CAN) and ‘Millhouse’ (CAN); multi-row hulled ones ‘AC Wes­tech’ (CAN) and ‘AC Alma’ (CAN). The prospect of further research is to involve the selected accessions into creation of new source material and establish the peculiarities of the inheritance of grain number per spike, as well as to identify the relationship of this trait with other yield components.
ASSISTÊNCIA DE ENFERMAGEM ÀS PESSOAS COM FERIDAS NO MUNICÍPIO DE SANTA CRUZ/RN: RELATO DE EXPERIÊNCIA
Authors: RIBEIRO BARRETO RAVANA AMALIA , Da Silva Isabela de Lima , Dos Santos Medeiros Edriana Mayara , Fernandes de Carvalho Louise Maria , Soares da Silva Ilisdayne Thallita
Published: December 2021

O presente relato possui como objetivo descrever a experiência dos discentes acerca das ações do projeto de extensão intitulado: “Assistência de enfermagem às pessoas com feridas no município de Santa Cruz/RN”. As ações do projeto supracitado ocorriam na Clínica Escola de enfermagem da FACISA/UFRN e nos domicílios dos pacientes. As atividades consistiam em treinamento dos integrantes; atendimento conforme Processo de Enfermagem; capacitações dos profissionais de saúde e cuidadores; divulgação cientifica por meio das redes sociais do projeto. Durante esse período foi possível oferecer a sociedade um serviço de qualidade, além de oferecer um espaço para os discentes aprimorarem a prática manual e o julgamento clínico.

Palavras-chave: Ferimentos e lesões; enfermagem; sistema único de saúde.
Corrigendum to: Chloro-s-triazenes-toxicokinetic, Toxicodynamic, Human Exposure, and Regulatory Considerations
Authors: Abass Khaled , Pelkonen Olavi , Rautio Arja
Published: December 2021

An error appeared in the graphical abstract and figure no. 1 of the article entitled “Chloro-s-triazines-toxicokinetic, toxicodynamic, human
exposure, and regulatory considerations” by Khaled Abass, Olavi Pelkonen and Arja Rautio, Current Drug Metabolism 2021, 22(8), 645-656.

We regret the error and apologize to readers.

The original article can be found online at https://doi.org/10.2174/1389200222666210701164945
The Potential of Natural Products in the Treatment of Triple-negative Breast Cancer
Authors: Ke Danny Yu Jia , El-Sahli Sara , Wang Lisheng
Published: December 2021

Triple-negative breast cancer (TNBC) is a subtype of breast cancer that lacks receptors
for targeted therapy. Consequently, chemotherapy is currently the mainstay of systemic treatment
options. However, the enrichment of cancer stem cells (CSC, a subpopulation with stem-cell characteristics
and tumor-initiating propensity) promotes chemo-resistance and tumorigenesis, resulting
in cancer recurrence and relapse. Furthermore, toxic side effects of chemotherapeutics reduce patient
wellbeing. Natural products specifically compounds derived from plants, have the potential to
treat TNBC and target CSCs by inhibiting CSC signaling pathways. Literature evidence from six
promising compounds was reviewed, including sulforaphane, curcumin, genistein, resveratrol, lycopene,
and epigallocatechin-3-gallate. These compounds have been shown to promote cell cycle
arrest and apoptosis in TNBC cells. They also could inhibit the epithelial-mesenchymal transition
(EMT) that plays an important role in metastasis. In addition, those natural compounds have been
found to inhibit pathways important for CSCs, such as NF-κB, PI3K/Akt/mTOR, Notch 1, Wnt/β-
catenin, and YAP. Clinical trials conducted on these compounds have shown varying degrees of effectiveness.
Epidemiological case-control studies for the compounds commonly consumed in certain
human populations have also been summarized. While in vivo and in vitro data are promising,
further basic and clinical investigations are required. Likely, natural products in combination with
other drugs may hold great potential to improve TNBC treatment efficacy and patient outcomes.
Asymmetric Synthesis of 2,3-Dihydrofurans via Squaramide Catalyzed
Michael-Alkylation Reaction
Authors: Ma Zhi-Wei , Wang Chuan-Chuan , Chen Xiao-Pei , Sun Bin , Tao Jing-Chao , Lv Quan-Jian
Published: December 2021

A highly stereoselective methodology was developed to construct dihydrofurans. In the
presence of a bifunctional squaramide catalyst, the Michael addition/cyclization between cyclohexane-
1,3-dione and α-bromonitroalkenes occurred smoothly to provide the desired dihydrofurans with high
to excellent yields (90-94%) and good to high enantioselectivities (80-94% ee). This catalytic protocol
was compatible with a range of structurally distinct α-bromonitroalkenes.
Chiral Allenylcarbonyls – Underexploited Building Blocks for Complex
Synthesis
Authors: Yadavalli Krishna , Lepore Salvatore D.
Published: December 2021

Chiral allenylcarbonyls such as allenoates remain underutilized in complex synthesis
despite recent advances in synthesis methods to prepare them non-racemically. The field is now
ripe for the employment of this class of allenes as building blocks to facilitate the construction of
complex small-molecule compounds, such as bridged bicycles.
Benign Synthesis of Metal-organic Framework (MIL-101-Cr) and Evaluation of Carbon-
dioxide Adsorption Behaviour Employing Adsorption Isotherm Models
Authors: Kayal Sibnath , Singh Ayushi
Published: December 2021

Background:

In today’s world, rising temperature due to global warming is caused by higher concentration of carbon dioxide (CO2) emissions in the atmosphere. Metal-Organic Framework (MOF) materials have
the potential to be used in carbon dioxide capture and utilization technology.

Objective:

The purpose of this work is to prepare metal-organic framework materials by a benign synthesis method using water as the solvent, followed by the characterization and property evaluation for CO2 adsorption study.

Methods:

MIL-101-Cr metal-organic framework and its derivatives with alkali ion dopants were prepared by benign hydrothermal synthesis route, which were characterized by powder X-ray diffraction method. The adsorption
isotherms of CO2 for MIL-101-Cr and its derivatives were studied to comprehend the influence of alkali dopants
on CO2 sorption behaviour. The equilibrium uptakes of CO2 were further evaluated by fitting the isotherms with
Langmuir, Toth and Dubinin – Astakohv adsorption models to determine the adsorption parameters. Results: The
crystalline structural integrity of MIL-101-Cr is not affected by doping with alkali ions. The isosteric heat of CO2
adsorption is diminished with an increase in alkali dopant size, while the induced surface structural heterogeneity
increases with increasing alkali dopant size.

Conclusion:

The equilibrium and thermodynamic parameters calculated from this study are useful
for applications in carbon dioxide capture and utilization technology.
N-heterocycles: Recent Advances in Biological Applications
Authors: Dinodia Monica
Published: December 2021

Nitrogen based heterocycles display an impressive repertoire of biological activities, including antioxidant, antimicrobial, anti-tuberculosis, analgesic, anti-inflammatory, anti-viral, anti-HIV, anti-cancer, anti-helminthic, and other pharmacological activities. Numerous novel nitrogen-based heterocycles have been synthesized, which showed various physiological properties, and their application in medicinal chemistry is ever-growing. The present review will provide an in-depth view of N-heterocyclic compounds that showed biological activities in the last 5 years (2017-2021). This review article will be helpful for the structural design of effective and sustainable N-heterocyclic drugs against diseases with minimal side effects.
β-sitosterol in Various Pathological Conditions: An Update
Authors: Yadav Poonam , Chauhan Chandan , Singh Sanjiv , Banerjee Sugato , Murti Krishna
Published: December 2021

Phytosteroids are biologically active compounds found naturally in herb plasma membranes,
with a chemical composition similar to animal plasma membrane cholesterol. It can be
found in almost all fats abundant plant’s diets. One of the vital phytosterols is β-sitosterol which
has several biological activities. It has been proved in various in-vivo and in-vitro research in
which β-sitosterol stabilized several physiological activities like as antioxidant, CNS activity (like
anti-alzheimer, anxiolytic and sedative effects, CNS depressant activity), lipid-lowering effects
(like nonalcoholic fatty liver disease), antidiabetic, anti-inflammatory and analgesic effects, anticancer
and immunomodulatory, protective effects in pulmonary fibrosis, wound healing effects and
anti-viral and COVID-19 activity. The experimental research on β-sitosterol shows that it can be
used as a nutritional supplement to combat variousexisting diseases. In this review, we are highlighting
the most significant pharmacological action of β-sitosterol on the basis of available literature.
A Review on Bioactive Constituents of Essential Oils as Mosquito Repellent
Authors: Dutta Rajat Subhra , Sahu Supriya , Mazumder Bhaskar
Published: December 2021

Currently, the research focus has been on finding new alternatives to synthetic mosquito
repellents due to their toxicity. Natural products act as a suitable alternative since plant-based
mosquito repellents have been used traditionally due to their low toxicity. Essential oils as mosquito
repellent have gained importance due to various functional bioactive constituents. Different formulations
of essential oils have been studied from time to time to enhance the stability and protection
time. However, the underlying mechanism of repellent activity of the bioactive constituents
against specific mosquito species remains unexplored. This review focuses on the various sources
of essential oil with their bioactive components and their receptor-based mechanism of action for
inducing mosquito repellency against different mosquito species. Furthermore, a comparison of the
various formulations of essential oil-based mosquito repellents with synthetic repellents has been
discussed.
Pharmaceutical Lozenges: Recent Trends and Developments with an Update
on Research and Patents
Authors: Kumar Rajesh , Kulkarni Mangesh Pradeep , Sharma Arun , Tanwar Sagar , Vandana Parashara Bhattar , Wadhwa Sheetu , Singh Gurvinder , Kumar Pardeep
Published: December 2021

Pharmaceutical oral dosage forms are tremendously preferred by both consumers as well
as pharmaceutical manufacturers owing to the plethora of benefits they offer. Lozenges (LZs) are
one of the dosage forms that provide a palatable means of drug administration and have great importance
with respect to their pharmaceutical applications. LZs offer additional benefits to pediatric
and geriatric patients, along with people having problems associated with the gastro-intestinal
tract. Dysphagia is a common problem faced by all age groups, which gives rise to the need for
LZs. Moreover, the foremost merit presented by the medicated LZs includes its augmented retention
time in the oral cavity that results in an enhanced bioavailability for buccal or upper gastro-intestinal
disorders. Further, LZs can also be used to bypass the first-pass effect. The present review
covers various aspects of LZs such as formulation, manufacturing techniques, evaluation parameters,
marketed products, patents, and a compilation of research work that has been done on
lozenges as a delivery system.
The influence of roselle-based wedang uwuh (Hibiscus sabdariffa L.) on SOD (superoxide dismutase) and MDA (malondialdehyde) of cigarette smoke-exposed rat
Authors: Dewanti Widyaningsih Tri , Alif Nugroho Muhammad Fawzul
Published: December 2021

Cigarette smoke is the leading cause of several respiratory diseases because it contains high free radical compounds. These free radical compounds can be neutralized with antioxidants obtained from natural ingredients such as roselle. Roselle contains various bioactive compounds and consumes in the form of infusion. Mixing roselle with various herbs as wedang uwuh can increase the antioxidant content. Wedang uwuh is a beverage consisting of various combinations of herbs such as sappan wood, cloves, and cinnamon. This study aims to analyze levels of MDA and SOD in rats exposed to cigarette smoke and given wedang uwuh. This research was conducted on 30 white male Wistar rats that divided into six groups- P0 (normal control), P1 (roselle-based wedang uwuh), P2 (commercial wedang uwuh), P3 (smoke control), P4 (smoke + roselle-based wedang uwuh), P5 (smoke + commercial wedang uwuh). The dose of wedang uwuh is 2.7 ml/kg BW, and the dose of exposure to cigarette smoke is one cigarette for 5 minutes for 30 days. The differences between each group were analyzed using the one way ANOVA test and HSD advanced test. Statistical results showed that giving roselle-based wedang uwuh (P4) significantly reduced MDA levels and increased SOD than the smoke control group (P3). Roselle-based wedang uwuh reduce the MDA levels and increase SOD better than commercial wedang uwuh.
Glucohealth: The potential of porang (Amorphophallus muelleri) acid hydrolysed glucomannan as an inhibitor of SARS-CoV-2 interaction with ACE2
Authors: Hasnanuha Ulayya Amira , Zaki Mubarok Ahmad , Widodo Widodo , Bambang Widjanarko Simon , Eklesia Marlita
Published: December 2021

The novel SARS-CoV-2 that causing global pandemic COVID-19 known to enter the host cell using the hACE2 as cell receptor. SARS-CoV S1 protein cleaves the ACE2 receptor, then the S2 subunits facilitates the cell membrane fusion, the inhibition of S1-ACE2 interaction can help develop anti SARS-CoV-2 medication. Porang glucomannan is a polysaccharide known as immunomodulator but never reported as anti-virus by direct inhibition of viral entry. Glucohealth was developed to investigate its potential. Method: Glucohealth is a glucomannan hydrolysate (HGM) that made from porang (Amorphophallus muelleri). Hydrolysis was carried using HCl in different concentration (0.25N, 0.5N, 1N) then analyzed its inhibitor activity using ELISA kit. Result: Higher HCl concentration produced HGM with smaller average particle size and lower glucomannan content. However, ELISA studies showed that glucomannan, including its hydrolysates, have the potency to bind with S1 protein and inhibit the binding activity of S1-ACE2. Degraded glucomannan proven to have better bioactivity and able to interact with pathogen to inhibit its cell entry. This project should be a gateway for further biomedical study of glucomannan from Indonesia’s local tuber and new approach to produce more natural therapy against COVID-19.
KONSEP DEFERRED PROSECUTION AGREEMENT (DPA) DALAM PERTANGGUNG-JAWABAN PIDANA KORPORASI SEBAGAI BENTUK ALTERNATIF PENYELESAIAN SENGKETA
Authors: Ferdian Ardi
Published: December 2021

Corporate prosecution through formal prosecution is considered to be able to destroy the corporation. If possible, the punishment of the corporation should not cause the corporation to go bankrupt and go bankrupt. The entanglement of corporations in criminal law does not only occur in Indonesia, in the world several phenomenal big cases have disrupted the company's health, which has impacted the company to make efficient by closing several of its subsidiaries and automatically downsizing the number of employees, namely the case that happen to Siemens Aktiengesellschaft (AG) and Volks Wagen (VW). To minimize the bankruptcy of corporations as a result of being convicted, several countries apply the Deferred Prosecution Agreement. The Deferred Prosecution Agreement is an alternative form of dispute resolution carried out outside the court. The author wants to know how the advantages and disadvantages of implementing the Deferred Prosecution Agreement if it is applied in Indonesia by using a conceptual approach and a comparative approach to the application of the Deferred Prosecution Agreement in England and America, to produce the concept of implementing the Deferred Prosecution Agreement in Indonesia. The results of the author's research, the concept of setting up a Deferred Prosecution Agreement at least contains: 1) Corporate approval for cooperation, 2) Process supervision by Judges, 3) Determining the term of the agreement, 4) Standard agreement clauses, 5) Considerations for the use of deferred prosecution agreement only for certain cases. However, we also need to know the advantages and disadvantages of this Deferred Prosecution Agreement concept if applied in Indonesia. The advantages are: 1) The company's reputation and trust are maintained, 2) Minimizes corporate bankruptcy, 3) Shorten, simple and low-cost case resolution, 4) Prosecutors are given the power to regulate the contents of the agreement. Weaknesses: 1) Prone to abuse of authority, 2) Need to make special rules (Lex Specialis). The author suggests that if you apply the concept of the Deferred Prosecution Agreement to corporate crimes, the attorney general should make regulations that regulate the guidelines for the implementation of the Deferred Prosecution Agreement and the standard operating procedures of the prosecutor dealing with the Deferred Prosecution Agreement. If supervision is needed, it is necessary to make special rules regarding the Supervisory Board.
KAJIAN YURIDIS EFEKTIFITAS PENYELESAIAN KREDIT MACET MELALUI LELANG HAK TANGGUNGAN
Authors: Ningsih Ayup
Published: December 2021

In a debt agreement that includes a guarantee regulated in the Mortgage Law, the form of legal protection provided by the State through the Mortgage Law to the creditor is the authority to execute the object of the debtor's guarantee or auction. Implementation of the auction through the State Auction Institution, namely the Office of the State Assets and Auction Service (KPKNL). The purpose of writing this article is to find out the arrangement and implementation of mortgage auctions at KPKNL. The method used is empirical juridical, with the research location at KPKNL Semarang PMK No. 213/PMK.06/2020. Auction of Mortgage through KPKNL is an effective solution for both parties in the case of debtors defaulting, because KPKNL applies regulatory procedures according to applicable regulations that protect the interests of both parties, debtors and creditors properly, which are guaranteed by regulations. The rights of creditors must be protected when the debtor defaults. Settlement of bad debts through auctions must be carried out as the final "ultimum remidium" step for debtors.
READY TO ADAPT TO NEW HABITS COVID-19 PANDEMIC INVOLVING HEALTH CADRES
Authors:   Clinical Nursing Program, Faculty of Nursing and Midwife, Universitas Nahdlatul Ulama Surabaya, Rusdianingseh Rusdianingseh , Hatmanti Nety Mawarda ,   Clinical Nursing Program, Faculty of Nursing and Midwife, Universitas Nahdlatul Ulama Surabaya, Roesbiantoro Andi ,   Medical Undergraduated Program, Faculty of Medicine, Universitas Nahdlatul Ulama Surabaya, Winarno Didik Dwi ,   Public Health Center Kebonsari Surabaya
Published: December 2021

Adaptation to New Habits is an act of implementing a new life order needed to maintain productivity during the COVID-19 pandemic by implementing transmission prevention behaviors or COVID-19 health protocols. This community service is an activity that aims to improve the knowledge and skills of health cadre in helping to improve family health by emphasizing the Adaptation of New Habits during the Covid-19 pandemic in the Kebonsari Surabaya. The COVID-19 pandemic has limited the activities of health cadre in the community so that it needs to be refreshed regarding health materials in the hope that through the health cadre, the adaptation of new habits during the covid-19 pandemic will be well socialized in the community. The method used in this community service activity is the provision of health education related to Adaptation to New Habits and a review of the skills of health cadre in providing health education to the community. The media used is a flipchart. The result of this community service activity is an increase in cadre knowledge by 30% regarding the material for adapting new habits during the covid_19 pandemic. Education through flipchart media is one way to increase knowledge.
A Review of Microplastics Risk Assessment in the Coastal Environment
Authors: Balasubramaniyan Balakrishnan
Published: December 2021

Pollution from microplastics has recently become a prevalent threat to the ecosystem. Microplastics with a dimension less than or equal to 5 mm are smaller. There are many ways that microplastics can reach the atmosphere. By various mechanisms, the breakdown of macro plastics will happen. Chemical degradation, tire abrasion, is the most common forms of degradation. Microplastics (MPs) pollution in the coastal and marine ecosystem is currently a global problem. Transferring MPs from land to sea and allowing them to enter the food chain has a direct negative impact on marine life and human health. The combined toxicity effects of MicroPlastics (MPs) and other contaminants in marine environments, as well as their toxicity effects and mechanisms based on a variety of environmentally important test organisms, were also covered in this study.
An Updated Review on Nanomaterials for Biomedical Advancements: Concepts and Applications
Authors: Adhikary Krishnendu
Published: December 2021

The sphere of Nanotechnology encompasses most of our lives and houses biomedicine and biomedical advancements. Nanoparticles owing to their minuscule sizes and due to various physicochemical and electrical properties have been exploited in pharmaceutical industries, agriculture, packaging, cosmetic, food industries. Nanomedicine is a laboratory-designed molecular-level pharmaceutical material that has revolutionized diagnostic techniques and therapeutics. Nanoscience and nanotechnology and their wide applications have become spread field worldwide because nanomaterials have novel and unique properties. Nanotechnology involves understanding and manipulating materials normally in the size range of 1 to 100 nm, where they show completely novel physicochemical properties from their bulk counterpart. The capacity to study compounds at the molecular level has aided the hunt for materials with exceptional qualities for medical applications. Nanotechnology in recent days is applied in the designing of nano biosensors. Nanobiosensors are biological molecules immobilized onto the surface of a signal transducer. The application of nano biosensors in the field of disease detection has increased in recent years which has influenced in research of cancer and biosensing. Due to the high surface area of nanoparticles, they are important in the production of nano biosensors with high levels of sensitivity and diminish the response times. However, a comprehensive review regarding the type, mode of function, and their application in various diseases is missing. Nano Deterministic lateral displacement technology that provided exosome splitting based on size differences has resulted in providing the much-needed boost to cancer research. The time taken for cancer screening has been reduced drastically. that This review aims to describe the utilization of nano deterministic lateral displacement technology, nano biosensors, and their applications in certain disease diagnoses.
Oporto ... (1955)
Authors: Resende Nuno
Published: December 2021

Oporto and the Douro: views and monuments, cujo texto e arranjo gráfico ficaram a cargo de Frederic P. Marjay, foi uma obra editada em 1955 pela livraria Bertrand, em Lisboa, Portugal. Ocupa um lugar despercebido entre as várias publicações de propaganda turística portuguesa que veiculavam a ideia de um país pitoresco e progressista, que começou a ser gizado pela Política do Espírito por volta de 1932, mas com raízes nos últimos anos da Monarquia. O livro, com uma parte composta ao modo de álbum, chama a atenção pelas suas fotografias a preto e branco de página inteira: vistas de locais, monumentos, reprodução de pinturas históricas e retratos de tipos sociais, marcadas por um ritmo contrastante de brancos e negros, com características pictorialistas. Analisar o arranjo gráfico da obra, a cargo de Marjay, e compreender, através dos fotógrafos e das suas fotografias, os significados deste trabalho (propagandístico, político e artístico), refletindo sobre as temáticas veiculadas, é o nosso objetivo principal.