bluuebunny/crossref_metadata_2025 huggingface dataset:
Problem Solving Therapy-induced Amygdala Engagement Mediates Weight Loss and Lifestyle Behavior Change in Patients With Obesity and Depression: A Randomized Controlled Trial
Authors: Lv Nan , Lefferts Wesley K , Xiao Lan , Goldstein-Piekarski Andrea N , Wielgosz Joseph , Lavori Philip W , Simmons Janine M , Smyth Joshua M , Stetz Patrick , Venditti Elizabeth M , Lewis Megan A , Rosas Lisa G , Snowden Mark B , Ajilore Olusola A , Suppes Trisha , Williams Leanne M , Ma Jun
Published: August 2020

Background: Behavioral interventions for obesity have modest and variable effectiveness. Emotion dysregulation may hinder effective weight loss interventions, especially among those with comorbid depression. Whether neural mechanisms related to emotion dysregulation mediate the effect of behavioral intervention on improving health behaviors in obesity combined with depression is unknown. Hyperactivation of the amygdala and loss of functional connectivity with the anterior cingulate regions are neural characteristics of unhealthy responses to negative emotion and accompanying emotion dysregulation. Methods: Using data from a randomized clinical trial of 108 primary care adult patients with obesity and depression, we investigated whether changes in amygdala activity and connectivity following problem solving therapy for depression over 2 months mediate weight loss, physical activity, and/or dietary outcomes at 6 and 12 months. Results: Compared with controls (n=49), intervention participants (n=59) had a significant blunting of the otherwise unhealthy increase in activity of the bilateral amygdala at 2 months (right: -0.83, 95% CI -1.55 to -0.11; left: -0.86, -1.63 to -0.10). While increases in amygdala activity significantly correlated with decreases in leisure-time physical activity levels and total energy expenditure at 12 months in the control group, this relationship was tempered or reversed among intervention participants (for physical activity, right: usual care -692.9, -1365.3 to -20.6; interaction 652.2, -115.4 to 1419.9; left: usual care -686.0, -1127.9 to -244.1; interaction 664.7, 73.1 to 1256.4; for energy expenditure, right: usual care -1.82, -3.08 to -0.56; interaction 1.94, 0.50 to 3.38; left: usual care -1.72, -2.51 to -0.93; interaction 1.89, 0.84 to 2.94). Compared with controls, intervention participants had a significant increase of the otherwise unhealthy loss of amygdala-subgenual anterior cingulate connectivity at 2 months (0.78, 0.05 to 1.52). This increase in functional connectivity significantly correlated with a decrease in BMI at 6 months among intervention participants (usual care 0.04, -0.42 to 0.50; interaction -0.61, -1.20 to -0.02) and an increase in fruit and vegetable intake at 12 months across all participants (usual care 1.42, 0.27 to 2.57; interaction -0.95, -2.36 to 0.46). Conclusions: These findings highlight potential neural mechanism for optimizing the efficacy of behavioral intervention in comorbid obesity and depression.Trial registration: ClinicalTrials.gov#NCT02246413.URL: https://clinicaltrials.gov/ct2/show/NCT02246413.
Is Surgery Better Than Conservative Treatment for Proximal Humeral Fracture: A Systematic Review and Meta-Analysis
Authors: Gong Dawei , Lin Tianye , Xu Jingli , Wang Xiaobo , Li Jian , Zhao Heran , Zhou Chi , Chen Leilei , Wang Haibin
Published: August 2020

Background: Previous studies had compared the effectiveness of surgical and conservative treatment in proximal humeral fracture (PHF), suggesting that both treatments were effective for displaced fractures. However, which treatment is more effective, especially in the elderly patient population, remains controversial to date. This study aims to evaluate the efficacy of the two treatment methods, including functional outcome scores, complications, etc.Methods: We searched four databases (MEDLINE, Web of Science, EMBASE, Cochrane Library) from the inception of the databases to March 2020. Within the scope of the search, the publication time and language of the relevant literatures were not limited. The meta-analysis directly compared the results and complications of the two groups and subgroups. Results: We included 11 comparative studies into our meta-analysis. The contents of the study included 7 randomized controlled trials (RCTs) and 4 non-randomized controlled trials (nRCTs). The pooled data demonstrated that there was no significant difference in postoperative Constant score between surgical and conservative treatment in the RCT subgroup, but there were differences among the nRCT and prosthesis subgroup. Although there was no significant difference between the surgery and conversation group in the major postoperative complications, the subgroup analysis showed fewer complications in the joint prosthesis replacement group. Conclusion: Both treatments could provide better clinical results for patients. The joint prosthesis replacement may offer additional benefits in terms of reduced complications and postoperative function. Furthermore, due to the increasing number of prosthesis replacements and the advent of the aging age, we should consider the individual differences between patients and enrich the clinical efficacy through the personal experience of surgeons before choosing treatment options.
Comparison of the Therapeutic Effects of Short-Segment Posterior Fixation With Monoaxial Pedicle Screws or Polyaxial Pedicle Screws via Injured Vertebra on Thoracolumbar Fracture
Authors: Yao Wenye , Guo Runsheng , Lai Qi , Zhang Bin
Published: August 2020

Purpose: To evaluate the therapeutic effects of short-segment posterior fixation with monoaxial pedicle screw or polyaxial pedicle screw via injured vertebra on thoracolumbar fracture.Methods: All patients who underwent short-segment posterior fixation with monoaxial pedicle screws or polyaxial pedicle screws in the injured vertebra of a thoracolumbar fracture (T12-L2). The clinical and radiological data such as the correction of deformity, sagittal profle and record of the perioperative morbidity of the patients were analyzed.Results: There were 63 patients (21 males and 42 females) with an average age of 44.7 years and were categorised into two groups: monoaxial pedicle screws group (group A) and polyaxial pedicle screws group (group B). There were no significant differences in age, gender, fracture site, TLISS Score, ASIA Score, AO Classification, hospital stay, Injury-to-operation intereval, and associated injury between the two groups (P>0.05). Howere, compared with group B, the injury vertebral endplate centre ratio significantly increased postoperatively and at the final follow-up (P<0.05) in group A.Conclusion: Short-segment posterior fixation with monoaxial or polyaxial pedicle screws via the fracture level for thoracolumbar fracture can achieve kyphosis correction, reduce sagittal alignment correction failure, and maintain anterior vertebral height. The insertion of monoaxial pedicle screws at the fracture level after thoracolumbar vertebral fracture has a flick up ffect on the central vertebral body of the injured vertebrae, which is beneficial to the recovery of the vertebral endplate.
Increased Tumor-Infiltrating Plasmacytoid Dendritic Cells Promote Cancer Cell Proliferation and Metastasis via TNF- α/NF-κB/CXCR-4 Pathway in Oral Squamous Cell Carcinoma
Authors: Han Nannan , Li Xing , Wang Yupu , Wang Lin , Zhang Chunye , Zhang Zun , Ruan Min , Zhang Chenping
Published: August 2020

Background

Tumor-infiltrating immune cells are closely associated with tumor occurrence and progression. The present study explored the potential mechanism of tumor-infiltrating plasmacytoid dendritic cells (pDC) mediating the proliferation and metastasis of cancer cells in oral squamous cell carcinoma (OSCC).
Methods

pDC distribution was detected by immunofluorescence and flow cytometry. CXCR-4/7 expression was detected by immunohistochemistry and western blotting. Cell proliferation and migration were measured by CCK-8, colony formation, wound healing and transwell assays. ELISA and western blotting were used to investigate cytokines secretion and NF-κB pathway activity. Nude mice xenograft model and footpad metastasis model were used to evaluate pDC-mediated tumor growth and metastasis in vivo.
Results

Increased tumor-infiltrating pDC in OSCC was significantly associated with tumor size, lymph node (LN) metastasis and CXCR-4 expression. Tumor-infiltrating-pDC- conditioned medium from OSCC patients significantly promoted tumor cell proliferation and invasion via enhancing its CXCR-4 expression through NF-κB pathway in vitro, which was regulated by pDC-derived TNF-α secretion. In vivo experiments further demonstrated that tumor-infiltrating pDC promoted tumor growth and LN metastasis via TNF-α/NF-κB/CXCR-4 axis.
Conclusions

Tumor-infiltrating pDC promoted oral cancer growth and metastasis via activating the TNF-α/NF-κB/CXCR-4 pathway and may serve as a potential immunological target for the treatment of OSCC.
The expression tendency and prognostic value of PDGFRβ in oral cancer
Authors: Wang Lili , Song Hongguang , Yang Shiming
Published: August 2020

Background

Oral cancer is a common malignant tumor in head and neck with poor prognosis. This study aimed to determine the expression tendency and prognostic value of PDGFRβ in oral cancer.

Methods

The mRNA expression level of PDGFRβ in the oral cancer tissues and adjacent normal tissues of oral cancer patients were detected by quantitative real-time polymerase chain reaction (qRT-PCR). And the association of PDGFRβ expression with clinicopathological characteristic was analyzed via chi-square test. Then we used Kaplan-Meier analysis to analyze the effects of PDGFRβ expression on the overall survival of oral cancer patients. The multivariate cox analysis was used to evaluate its prognostic value.

Results

The results indicated that the mRNA expression level of PDGFRβ was significantly increased in oral cancer tissues compared with that in the adjacent normal tissue ( P < 0.001). And its expression is positively associated with clinical stage, T stage, lymph node metastasis and histological grade. Kaplan-Meier analysis revealed that patients with high expression of PDGFRβ had markedly worse overall survival than those with low expression of PDGFRβ (log rank test, P < 0.05). Additionally, cox regression analysis revealed that the high expression of PDGFRβ was an independent prognostic maker in oral cancer patients.

Conclusion

PDGFRβ is up-regulated and involved in the development of oral cancer. Moreover, it could be an independent prognostic bio-marker for oral cancer.
Aberrant expression of lncRNA Sox2ot is associated with advanced tumor progression and poor prognosis in patients with colorectal cancer
Authors: Zhang Keqian , Mao Tianqi , He Zhicheng , Wu Xiaojiao , Peng Yu , Chen Yanrong , Dong Yan , Ruan Zhihua , Wang Zhe
Published: August 2020

Background: Long non-coding RNA (lncRNA) plays an important role in carcinoma progression and prognosis. However, little is known about the pathological role of lncRNA Sox2ot in colorectal cancer (CRC) patients. This study sought to investigate the expression level of lncRNA Sox2ot in CRC, as well as explore its association with CRC progression and prognosis.
Methods: LncRNA Sox2ot expression was measured in 117 paired CRC tissues and adjacent non-cancerous tissues using quantitative real-time polymerase chain reaction (qRT-PCR). Then, the relationship between lncRNA Sox2ot expression and clinicopathological characteristic of CRC patients was detected by Chi-square test. Lastly, relationship between the expression level of lncRNA Sox2ot and overall survival (OS) was analyzed using Kaplan–Meier analysis and univariate and multivariate analyses were evaluated by Cox regression models.
Results: The expression level of lncRNA Sox2ot in CRC tissues were significantly higher than in the adjacent non-cancerous tissues (P<0.05). In addition, high lncRNA Sox2ot expression was positively correlated with N stage, T stage, TMN stage, distant metastasis, histological differentiation grade and lymph node involvement in CRC patients (all, P<0.05). Kaplan-Meier analysis showed that patients with high expression of lncRNA Sox2ot had a shorter OS than those with low lncRNA Sox2ot expression (log rank test, P<0.001). Moreover, in univariate and multivariate Cox regression models, lncRNA Sox2ot expression was an independent prognostic factor for CRC patients.
Conclusion: LncRNA Sox2ot over-expression may serve as an unfavorable prognosis predictor for CRC patients.
A comprehensive review of deep learning applications in hydrology and water resources
Authors: Sit Muhammed , Demiray Bekir Z. , Xiang Zhongrun , Ewing Gregory J. , Sermet Yusuf , Demir Ibrahim
Published: August 2020

The global volume of digital data is expected to reach 175 zettabytes by 2025. The volume, variety and velocity of water-related data are increasing due to large-scale sensor networks and increased attention to topics such as disaster response, water resources management, and climate change. Combined with the growing availability of computational resources and popularity of deep learning, these data are transformed into actionable and practical knowledge, revolutionizing the water industry. In this article, a systematic review of literature is conducted to identify existing research that incorporates deep learning methods in the water sector, with regard to monitoring, management, governance and communication of water resources. The study provides a comprehensive review of state-of-the-art deep learning approaches used in the water industry for generation, prediction, enhancement, and classification tasks, and serves as a guide for how to utilize available deep learning methods for future water resources challenges. Key issues and challenges in the application of these techniques in the water domain are discussed, including the ethics of these technologies for decision-making in water resources management and governance. Finally, we provide recommendations and future directions for the application of deep learning models in hydrology and water resources.
Uncovering Active Ingredients and Mechanisms of Spica Prunellae in the Treatment of Colon Adenocarcinoma: A Study Based on Network Pharmacology and Bioinformatics
Authors: Lei Yan , Yuan Hao , Gai Liyue , Wu Xuelian , Luo Zhixiao
Published: August 2020

Background:

As a well-known herb used in the treatment of colon adenocarcinoma
(COAD), Spica Prunellae (SP) shows favorable clinical effect and safety in China for many years,
but its active ingredients and therapeutic mechanisms against COAD remain poorly understood.
Therefore, this study aims to uncover active ingredients and mechanisms of SP in the treatment of
COAD using a combined approach of network pharmacology and bioinformatics.

Methods:

A comprehensive approach mainly comprised of target prediction, network construction,
pathway and functional enrichment analysis, and hub genes verification was adopted in the current
study.

Results:

We collected 102 compounds-related genes and 3549 differently expressed genes (DEGs)
following treatment with SP, and 64 disease-drug target genes between them were recognized. In
addition, a total of 25 active ingredients in SP were identified. Pathway and functional enrichment
analyses suggested that the mechanisms of SP against COAD might be to induce apoptosis of
colon cancer cells by regulating PI3K-Akt and TNF signaling pathways. Recognition of hub genes
and core functional modules was performed by constructing protein-protein interaction (PPI)
network, from which TP53, MYC, MAPK8 and CASP3 were found as the hub target genes that
might play an important part in therapy for COAD. Subsequently we further compared the
differential expression level and assessed the prognostic value of these four hub genes. These result
of verification suggested that SP exerted therapeutic effects against COAD via a PPI network
involving TP53, MYC, MAPK8 and CASP3.

Conclusion:

In this study, active ingredients and mechanisms of SP in the treatment of COAD
were systematically discussed, which provided the foundation for further experimental studies and
might act to promote its appropriate clinical application.
Withdrawal Notice: Review on Dengue Virus Fusion/Entry Process and Their Inhibition by Small Bioactive Molecules
Authors: Naresh Podila , Pottabatula Shyam Sunder , Selvaraj Jubie
Published: August 2020

The article has been withdrawn at the request of the editor of the journal Mini-Reviews in Medicinal Chemistry
due to incoherent content.

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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Recent Advances in the Analysis Full/Empty Capsid Ratio and Genome Integrity of Adeno-associated Virus (AAV) Gene Delivery Vectors
Authors: Hajba Laszlo , Guttman Andras
Published: August 2020

Adeno-associated virus (AAV) is one of the most promising viral gene delivery
vectors with long-term gene expression and disease correction, featuring high efficiency
and excellent safety in human clinical trials. During the production of AAV vectors, there
are several quality control (QC) parameters that should be rigorously monitored to
comply with clinical safety and efficacy. This review gives a short summary of the most
frequently used AVV production and purification methods, focusing on the analytical
techniques applied to determine the full/empty capsid ratio and the integrity of the
encapsidated therapeutic DNA of the products.
Engineering of Nanospheres Dispersed Microneedle System for Antihypertensive Action
Authors: Sardesai Mrunmayi , Shende Pravin
Published: August 2020

Background:

A combinational therapy is mostly preferred in hypertension treatment because
of low-dose and less side effects like pretibial edema, and gastrointestinal bleeding.

Objective:

So the objective of the present work was to formulate an advanced drug delivery system in
the form of bio-responsive microneedles by incorporating nifedipine, a cardiodepressant and diltiazem,
a vasodilator for effective synergism in the treatment of hypertension.

Methods:

The pH-responsive PLGA nanospheres of diltiazem were formulated using Water-in-Oil-in-
Water (W/O/W) double emulsion and solvent-diffusion-evaporation technique. These nanospheres were
added to nifedipine-PVP mixture and then incorporated into mold to develop microneedles.

Results:

The microneedles showed the release of nifedipine almost 96.93± 2.31% for 24 h due to high
PVP solubilization. The nanospheres of diltiazem on contact with acidic pH of skin managed to form of
CO2 bubbles and increase the internal pressure to burst PLGA shell due to pore formation. The mean
blood pressure observed for the normal group was 89.58 ± 3.603 mmHg, whereas the treatment with the
new formulation significantly reduced the mean blood pressure up to 84.11 ± 2.98 mmHg in comparison
to the disease control group (109.9 ± 1.825 mm Hg).

Conclusion:

This system co-delivers the drugs nifedipine and diltiazem in hypertension and shows an
advance alternative approach over conventional drug delivery system.
Evaluation of the Technological Potential of Grape Peels Through Patent Document Analysis: Agro-industrial Waste with Biotechnological Potential
Authors: Souza Euzelia L. , Leal Ingrid L. , Umsza-Guez Marcelo A. , Machado Bruna A.S.
Published: August 2020

Background:

Grape (Vitis vinifera L.) is consumed by old-world populations in its natural
form and is used to produce wine or juice. Currently, China is the largest grape producer in the world.
The red grapes stand out because of their phytochemical composition, more specifically their high
resveratrol levels. Resveratrol is a compound that has a number of different beneficial effects on health
and is mainly used in the food and cosmetic industries. Grape peel is a waste product and new strategies
based on nanotechnology can minimize its environmental impact and add value to this residue.

Objectives:

The first objective of this study was to evaluate the technological potential of utilizing
grape peel by researching and analyzing information extracted from patent documents filed worldwide
in order to identify the main countries that hold the research technology, the main depositors and inventors,
and the main areas of application. The second aim was to research and investigate grape peel
products that have been created using nanotechnology.

Methods:

An analysis of all patented documents related to grape peel processes, products, or different
industrial applications that may use nanotechnology was carried out. This was achieved by undertaking
a Derwent Innovation Index (DII) database search.

Results:

A total of 752 patent documents were identified in the surveyed area. These were assessed for
depositor country of origin, type of depositor, inventors, the evolution of deposits over time, and areas
of application. Only 6% of the total represented products and processes in the nanotechnology area.
There was a growth in the number of patent filings from 2015, which showed that the researched area
is a current and developing technology with new application possibilities. The main depositing countries
were China, the United States, and Japan, which dominate the researched technology. The identified
documents discussed using the grape peel to develop new food, medical and dental products.

Conclusion:

Over the last few years, different approaches have been suggested for the production of
nanoproducts based on grape peel. The results from this study showed that although incipient, nanotechnology
is a promising area of research that can be explored by universities and companies because
the products could have significant positive characteristics and, even though they are made out of a
byproduct, have great application potential.
Review on Disease, Dose, Destination and Delivery Aspects of Simvastatin
Authors: Devi Arpna , Kumar Maninder , Kumar Mohit , Mandal Uttam K.
Published: August 2020

Statins are the choice of drugs for the treatment and management of hypercholesterolaemia
because of their established lipid-lowering efficacy and safety profile. Among the various statins, simvastatin
is a very popular antihyperlipidemic drug with pleiotropic effects that have a wide range of applications
such as antioxidant, anti-inflammatory, antifibrotic effect as well as angiogenic activity.
However, poor biopharmaceutical characteristics like low solubility and high permeability make this
drug more challenging for formulation scientists in terms its delivery to different targeted areas. Oral
drug delivery systems, lipid nanoparticles, PLGA nanoparticles, sustained-release tablets, matrix-type
transdermal, co-encapsulating nanostructured lipid carriers are some of the strategies that have been
explored to address this issue. This review provides an update regarding the disease, destination, dose
and delivery associated with this wonderful lipid-lowering drug molecule.
Representaciones Sociales de Adolescentes pertenecientes a las Barras Futbolísticas de Tunja hacia su Colectividad
Authors: Suárez-Sierra María-Tatiana
Published: August 2020

El presente artículo de investigación surge de la pesquisa denominada “Representaciones Sociales de Adolescentes pertenecientes a las Barras Futbolísticas de Tunja hacia su Colectividad”, cuyo objetivo es determinar las representaciones sociales que tienen estos sujetos frente a sus hinchadas. La metodología es de corte cualitativo, el cual se fundamenta por el enfoque histórico-hermenéutico y por los estudios cualitativos de caso. La muestra para el presente estudio estuvo compuesta por 15 adolescentes de los 11 a 18 años, vinculados a las hinchadas de Aguante Sur Patriotas, La Mancha Ajedrezada, Desquicio Millonario, Los del Sur, Barón Rojo Sur, Pasión Escarlata y Artillería Verde Sur. La estrategia de recolección de información se basó en la aplicación de entrevistas semiestructuradas. El análisis de resultados se realizó desde el sistema categorial, el cual permitió ver que las creencias de los jóvenes hacia las agrupaciones se fortalecen mediante experiencias y procesos de socialización, que conllevan al establecimiento de axiomas y propósitos que contribuyen al fortalecimiento de la identidad, a nivel individual y grupal, mediante el uso de elementos simbólicos que, en algunos casos, son factores que potencializan beneficios en los sujetos y en otros son un medio que generan dificultades psicosociales que alteran el ciclo vital del adolescente.
Enfoques de aprendizaje en la materia de español en niños con trastornos de aprendizaje
Authors: Vega-Villanueva Nadia , Mendoza-Meraz Gerónimo , Carmona-García Lilia-Susana
Published: August 2020

Actualmente, en México, los niños que presentan trastornos de aprendizaje cursan todos los grados escolares junto con los niños regulares. En el estado de Chihuahua el Programa de Servicio Especializado Escolar, a través de un equipo profesional, pretende superar estas problemáticas en los niveles iniciales de la Primaria a los casos más graves, ya que no puede abarcar a toda esta población y, a su vez, proporcionar asistencia específica, a fin de que los niños superen lo más posible las deficiencias que les impide buen desenvolvimiento escolar. Los niños que cursan con trastornos leves deben superar sus problemáticas solos, buscando estrategias de aprendizaje por sí mismos, para consolidar los aprendizajes de cada asignatura. Ante este panorama, el objetivo de la presente investigación fue comparar los Enfoques de Aprendizaje en la materia de español, respecto a los promedios y género de sus alumnos, en los estudiantes con trastornos de aprendizaje que cursan 6º grado de Primaria en escuelas públicas de la ciudad de Chihuahua, Chih., México. Para llegar a los resultados, se llevó a cabo una investigación no experimental, de campo, comparativo y correlacional, de corte transeccional, realizada en Escuelas Primarias públicas. Se recabaron los datos, aplicando el cuestionario sobre Procesos de Aprendizaje R-LPQ-2F de Biggs, Kember y Leung (2001). Participaron, de forma individual y voluntaria, 227 Alumnos de 6° grado de Primaria, detectados por el equipo de USAER, con Trastornos de Aprendizaje en 35 escuelas. Resultados. Se observó el empleo de ambos enfoques, en distintos niveles, por parte de los Alumnos participantes. Se encontró predominancia del Enfoque Profundo. Las niñas emplean el Enfoque Profundo más que los niños y no se encontró relación entre los promedios de calificación anual de la materia de Español, con el empleo de ningún tipo de Enfoque de Aprendizaje.
Reproducible Machine Learning Methods for Lung Cancer Detection Using Computed Tomography Images: Algorithm Development and Validation
Authors: Yu Kun-Hsing , Lee Tsung-Lu Michael , Yen Ming-Hsuan , Kou S C , Rosen Bruce , Chiang Jung-Hsien , Kohane Isaac S
Published: August 2020

Background

Chest computed tomography (CT) is crucial for the detection of lung cancer, and many automated CT evaluation methods have been proposed. Due to the divergent software dependencies of the reported approaches, the developed methods are rarely compared or reproduced.

Objective

The goal of the research was to generate reproducible machine learning modules for lung cancer detection and compare the approaches and performances of the award-winning algorithms developed in the Kaggle Data Science Bowl.

Methods

We obtained the source codes of all award-winning solutions of the Kaggle Data Science Bowl Challenge, where participants developed automated CT evaluation methods to detect lung cancer (training set n=1397, public test set n=198, final test set n=506). The performance of the algorithms was evaluated by the log-loss function, and the Spearman correlation coefficient of the performance in the public and final test sets was computed.

Results

Most solutions implemented distinct image preprocessing, segmentation, and classification modules. Variants of U-Net, VGGNet, and residual net were commonly used in nodule segmentation, and transfer learning was used in most of the classification algorithms. Substantial performance variations in the public and final test sets were observed (Spearman correlation coefficient = .39 among the top 10 teams). To ensure the reproducibility of results, we generated a Docker container for each of the top solutions.

Conclusions

We compared the award-winning algorithms for lung cancer detection and generated reproducible Docker images for the top solutions. Although convolutional neural networks achieved decent accuracy, there is plenty of room for improvement regarding model generalizability.
NPK uptake and growth of maize on ombrogenous peat as affected by the application of mycorrhizal fungal multi-spores and compound fertilizers
Authors: Sahfitra Angga Ade , Hanudin Eko , Wulandari Cahyo , Utami Sri Nuryani Hidayah
Published: August 2020

This study investigated the effectiveness of mycorrhizal fungal multi-spores and inorganic fertilizers in increasing NPK uptake and growth of maize on ombrogenous peat soils in Riau. The experiment, which was carried out in a plastic house, was arranged in a completely randomized design (CRD) with two factors, consisting of five replications. The first factor was the application of mycorrhizal fungal multi-spores, consisting of two levels (with and without application). The second factor was the application of inorganic fertilizer, consisting of three levels (P0: without fertilizer, PM-1: mixture of 225 kg Urea + 100 kg SP-36 + 75 kg KCl + 1000 kg Dolomite, and PM-2: mixture of 450 kg Urea + 200 kg SP-36 + 150 kg KCl +2000 kg Dolomite). Observed data consisted of agronomic observations, soil observations, and mycorrhiza observations. Agronomic observations consisted of plant height, root dry weight, shoot dry weight, and N, P, K nutrient uptake, and soil observations consisted of total and available N, P, K nutrients in the soil. Meanwhile, mycorrhiza observations consisted of infected roots and spore populations. The data obtained were then analyzed using DMRT to see the significant effect of the treatments. There was no interaction effect of mycorrhiza and compound fertilizer on the variables of shoot and root dry weight, but the interaction effect was observed on the variables of of shoot N, P, K uptake and root P and K uptake.
Towards Adoption of a Human Rights Based Framework for Social Protection in Botswana
Authors: Solo Kholisani , Ntseane Dolly Mogomotsi
Published: August 2020

A clear gap in the debate on social protection in Botswana has been the lack of a thorough analysis on the human rights based framework. The aim of this paper is to provide an overview of the position of the government of Botswana regarding a right- based approach to social protection. The primary objective is to assess whether social protection regime in Botswana is backed by a legal framework. The paper starts by examining conceptual issues. Here we discuss the concept of social security and social protection. The next section examines international and regional instruments that have been formulated to protect the right to access social protection. Through this analysis, it will be clearly shown that although Botswana is officially committed to providing social safety nets to the poor and vulnerably, social protection is not yet entrenched in the legal framework. To arrive at this conclusion, a thorough analysis is made using the Human Rights-Based approach for social protection developed by the United Nations General Assembly and the Human Rights Council. In conclusion the paper provides recommendations on how Botswana can develop a sustainable human rights- based social protection framework.
Democracy of the Oppressed: A Perspective from below Alternative Perspective, Flawed Policies and Perceptions towards Adivasis—Past, Present and Future
Authors: Ganaie Dr. Nasir Ahmad
Published: August 2020

Book Review
VERBS OF SPEAKING IN SERBIAN AND ENGLISH PROVERBS
Authors: Pejčić Aleksandar
Published: August 2020

The aim of this paper is to perform a corpus analysis of verbs of speaking in 63 English and 60 Serbian proverbs in order to reveal the effect of their linguistic properties in signalling different metaphorical meanings of proverbs in the cognitive theoretical framework. The results reveal that prototypical verbs of speaking appear in approximately half of the sample of proverbs while the semantic markedness of verbs is achieved mostly lexically, although expectedly more so in the English language. The two languages also differ in the synonymy of these expressions and their metaphorical mapping. We propose three types of proverbs depending on the degree of abstraction of the speech act, in accordance with the generic is specific scheme, which we consider vital for the interpretation of proverbs.
PARTIAL TRANSPHONEMIZATION OF ENGLISH LOANWORDS IN SERBIAN: ACOUSTIC EVIDENCE FROM THREE VOWELS
Authors: Sudimac Nina , Stojičić Violeta
Published: August 2020

Following the principles of lexical borrowing which regulate the phonological adaptation of English loanwords in the Serbian language, we investigate the acoustics of the partial transphonemization of three English vowels. We have employed the Praat software in the acoustic analysis of speech to measure the values of the first three formants and the duration of vowels in accented positions in a sample of English loanwords integrated into Serbian in contrast to the corresponding vowels in English words. First, we contrast the acoustic features of the English vowels /ʌ/, /ɪ/ and /ʊ/ and the Serbian vowels /ɑ/, /i/ and /u/ by measuring the first three formants of the vowels in speech produced by English-Serbian native bilingual speakers. Second, we measure the duration of vowels in pairs of English words and their replicas in Serbian which we labelled ‘false acoustic pairs’ due to the differences in vowel length. The results verify the principle of substitution which governs the integration of loanwords on the phonological level in Serbian as a borrowing language, which requires that borrowed words comply with the phonological system of the language, in which case the phonological adaptation of phonemes of different qualities is partial.
RECEPTAREA LITERATURII SÂRBE ÎN ROMÂNIA ÎN ULTIMUL SFERT DE VEAC
Authors: Nedelcu Octavia
Published: August 2020

În prima parte a lucrării se face o scurtă trecere în revistă a activității de traducere din limba sârbă în limba română de-a lungul timpului, subliniindu-se importanța traducerilor în patrimoniul literar național. În continuare sunt prezentate traducerile operelor scriitorilor sârbi și ecourile acestora în critica literară ori valorizarea lor în diverse studii literare din ultimul sfert de veac. Cu precădere este vorba despre traducerile din creația lui Milorad Pavić, Miloš Crnjanski, Danilo Kiš și Ivo Andrić. Ultima pare a lucrării cuprinde o listă aproape completă de opere literare a scriitorilor sârbi traduși în limba română din 1990-2018.
RADIVOJE KONSTANTINOVIĆ SOBRE JORGE LUIS BORGES
Authors: Dickov Vesna
Published: August 2020

En este artículo nos ocupamos del papel de Radivoje Konstantinović en la recepción interpretativa de la obra literaria del escritor argentino Јorge Luis Borges en el área de la lengua serbia. En este sentido, el campo de nuestro interés está compuesto por varios textos (prefacios, postfacios, ponencias presentadas en las reuniones científicas internacionales) publicados por Radivoje Konstantinović durante la segunda mitad del siglo XX en  ediciones particulares impresas en el idioma serbio. Estos textos se presentan de una manera crítica, con respecto al criterio cronológico, a fin de señalar los parámetros cualitativos y cuantitativos básicos que son característicos para esta clase de recepción (tipo de textos, fecha y lugar de publicación, distribución, editores), con el objetivo de determinar la importancia de la influencia de Radivojе Konstantinovic en la formación y modificación del horizonte de expectativas de los lectores en relación con la aceptación de las creaciones literarias de Jorge Louis Borges en el área de la lengua serbia.
SOBRE LA INTERPRETACIÓN SIMBÓLICA Y TRADUCCIÓN DEJ.L. BORGES EN RADIVOJE KONSTANTINOVIĆ
Authors: Trivić Aneta
Published: August 2020

Este trabajo tiene doble objetivo: por un lado representamos los temas, símbolos y metáforas empleadas por J. L. Borges en su obra prosaicay dirigimos nuestra atención hacia su recepción e interpretación en el ámbito serbio (nos centramos en primer lugar ellaberinto como símbolo de la construcción espacio-temporal, psicológica,  existencial u onírica). Paralelamente exploramos las críticas y observaciones que sobre Borges ha elaborado profesor Radivoje Konstantinović, uno de los mejores conocedores de la obra borgeana. El segundo objetivo que perseguimos concierne el análisis traductológico: examinamos las soluciones y métodos traductológicos empleados en textos serbios por Konstantinović. En tal análisis partimos de la estructuración sistemática y jerárquica del sistema lingüístico y comentamos las soluciones gramáticas y estilísticas interesantes para los serbio hablantes. El corpus principal está basado en el relato La casa de Asterión y su traducción serbia Asterionovdom (ZUNS). En la investigación nos apoyamos en los métodos de interpretación simbólica/metafórica (cuando representamos y analizamos ideas y símbolos dominantes en la obra prosaica de J.L. Borges), análisis lingüístico y traductológico del texto en prosa y análisis contrastivo (cuando utilizamos los corpus paralelos para comparar las distintas soluciones traductológicas del mismo texto).
EL TÓPICO DE FRIVOLIDAD Y SUPERFICIALIDAD FEMENINA EN LA NOVELA POPULAR ESPAÑOLA (1840-1869)
Authors: Jovanović Snežana
Published: August 2020

Este trabajo aborda uno de los tópicos más arraigados en la cultura y literatura española del siglo XIX, sobre todo en las novelas publicadas entre 1840 y 1869 bajo el membrete de novela original o novela de costumbres contemporáneas, englobadas bajo el término de la novela popular. El estereotipo de la mujer frívola, coqueta, amiga del lujo y del dinero, de la mujer tentadora e intrínsecamente mala que causa la perdición del hombre.El trabajo se centra en el análisis de las formas bajo las que este tópico aparece, indaga en que clases sociales se dan los personajes que lo representan, si tienen entidad propia y si pueden tener el rol de protagonista o simplemente sirven de ejemplo de malas acciones o comportamientos que hay que condenar.
LE CHANGEMENT DE SENS DES LEXEMES EN DIACHRONIE
Authors: Miljković Ivana
Published: August 2020

Dans le cadre d’une analyse diachronique nous nous proposons d’étudier, du point de vue de la sémantique, les lexèmes français qui ont subi des changements de sens. L’objectif de nos recherches est de mettre en évidence les différents types d’évolutions du sens, tant pour les substantifs que pour les adjectifs et les verbes. Parfois le sens d’origine est perdu, parfois il continue de coexister avec un sens nouveau, parfois il a perdu son caractère polysémique, etc. Et les raisons de ces évolutions de sens sont variables, depuis un simple changement d’usage jusqu’à une évolution de vision sociétale. En nous basant sur un corpus incluant les lexèmes « panier », « compter/conter », « voler », « vilain », ou encore « calcul » nous allons nous attacher à caractériser les différents types d’évolution et leurs raisons historiques. Nous évoquerons toutes les relations sémantiques en diachronie, en insistant particulièrement sur le changement de sens, la polysémie et l’homonymie.
LA LITTERATURE AU PROFIT DE L’APPRENTISSAGE DE LA LANGUE : LE CAS DU FRANÇAIS LANGUE ETRANGERE
Authors: Simović Vesna
Published: August 2020

La littérature, considérée traditionnellement comme la meilleure expression de la langue, a toujours été liée à l’enseignement des langues étrangères. Le statut de la littérature a beaucoup changé lors de l’évolution des méthodologies de l’apprentissage/enseignement des langues allant de la consécration de l’apprentissage d’une langue jusqu’au évincement de la classe de langue au niveau débutant. Pourtant, elle a gardé sa place dans l’apprentissage/enseignement des langues jusqu’à nos jours. Considéré actuellement comme un document authentique témoignant des pratiques quotidiennes des natifs et de plus comme un document communicatif, le texte littéraire reste incontournable dans l’apprentissage des langues. Dans la présente contribution, nous nous proposons de montrer les modalités et les avantages de l’utilisation de la littérature pour l’apprentissage de la langue, plus précisément la langue française.
LA RENAISSANCE ET LE CLASSICISME : PARALLÈLES ENTRE DEUX ÉPOQUES DES LETTRES FRANÇAISES
Authors: Vučelj Nermin
Published: August 2020

La pierre angulaire de la Renaissance française et de l’Âge classique français fait leur enracinement dans l’antiquité gréco-romaine. Si l’humanisme refonde l’héritage antique et le Grand Siècle le reprend, devrait-il y voir une simple continuité entre l’époque de l’humanisme et l’Âge classique ? Parmi les théoriciens, les uns considèrent le classicisme français comme un second humanisme ou nomment la Pléiade la première école du classicisme, voire ils accentuent les parallélismes soulignant les similitudes entre ces deux époques des lettres françaises. Les autres théoriciens signalent la rupture du classicisme avec l’époque précédente et accentuent l’opposition entre la réforme de la Pléiade et la langue ronsardienne de l’imagination débridée, d’une part, et, d’autre part, la doctrine classique et la langue malherbienne annonçant la clarté et le rationalisme du Grand Siècle. Pour susciter de nouvelles considérations à ce sujet, cette recherche revalorise des parallèles entre deux époques et leurs poétiques que les théoriciens ont fait dans l’histoire littéraire, de la fin du xixe siècle, tout au long du xxe siècle, jusqu’au début du xxie siècle.
L’IMAGE DE L’ORIENT DANS LES RÉCITS DE CHATEAUBRIAND, LAMARTINE, NERVAL, GAUTIER ET FLAUBERT
Authors: Đurić Vladimir
Published: August 2020

Par une analyse comparative et imagologique, cet article examine la vision de l’Orient, plutôt imaginaire que documentaire, des écrivains romantiques tels Chateaubriand, Lamartine, Nerval, Gautier et d’un réaliste malgré lui – Flaubert. Le but de cet article sera alors de relever et souligner les différences ainsi que les nuances dans les images créées par ces grands auteurs et voyageurs de l’époque qui nous ont laissé des récits de voyage extraordinaires. Ceci dit, nous nous proposons de montrer diverses images référentes comme celles des Balkans, de la Grèce, de l’Égypte et de la Palestine où les réflexions différentes de nos écrivains voyageurs se croisent. Nous allons finir par la constatation qu’il y a toujours une idée civilisatrice omniprésente à l’Orient que nos auteurs mettent en valeur.
LE PREMIER HOMME D’ALBERT CAMUS : LE PROBLÈME DU GENRE
Authors: Cvetković Vanja
Published: August 2020

Le Premier Homme d’Albert Camus est une œuvre autobiographique, mais, vu qu’il s’agit d’un livre inachevé, pourrions-nous jamais préciser son genre ? Cet article cherche à montrer de quelle manière cet ouvrage erre dans le champ autobiographique, tout en essayant de l’y déterminer la place. Ainsi, en suivant les critères formels du genre établis par Philippe Lejeune dans le Pacte autobiographique (1975), nous examinerons si les éléments autobiographiques présents dans le livre suffisent de le qualifier d’autobiographie de Camus, ou il faudra mieux le classifier parmi les genres voisins : le roman autobiographique, défini par Lejeune dans la suite de son Pacte, ou l’autofiction, prise dans son sens originel donné par Doubrovsky dans le Fils (1977) et les écrits qui l’ont suivi. Ainsi nous analyserons non seulement la nature de l’ouvrage camusien, mais aussi les nuances fines qui séparent les genres dans la théorie, tout en montrant leur proximité sur ce beau example de la pratique littéraire.
EFFECTS OF EXERCISE PROGRAM ON COORDINATION AND EXPLOSIVE POWER IN UNIVERSITY DANCE STUDENTS
Authors: Stošić Dejan , Uzunović Slavoljub , Pantelić Saša , Veličković Saša , Đurović Marko , Piršl Danica
Published: August 2020

The aim of this research is to determine the effects of a ten-week modern and recreational dance exercise program and trunk and leg muscle strengthening exercises on the coordination and explosive power of student-age female dancers. The total number of participants was 54, of which 27 made up the experimental group who participated in an experimental exercise program and 27 the control group. The experimental group performed Hip Hop and Dancehall dances and trunk and leg muscle strengthening exercises 3 times a week for 90 min each. The control group had no additional forms of exercise other than regular daily activities. The coordination of the participants was evaluated on the basis of six tests (Side Steps, 20 Steps forward Twirling a Baton, Skipping the Horizontal Jump Rope, Turning in 6 squares, Hand-Foot Drumming and Agility test with a Baton) and two tests for determining explosive power parameters (the squat jump and countermovement jump). Results showed statistical significance between the groups in 5 variables of coordination at the multivariate and univariate level (p<.05, p<.01), and in both variables of explosive power at the univariate level (p<.05). A large and intermediate effect size of the experimental program was determined for 5 variables of coordination, and intermediate effect size for both variables of explosive power. The results of this study showed that a ten-week exercise program for recreational and modern dance and exercises for strengthening the muscles of the torso and legs have a positive effect on the changes in the parameters of coordination and explosive power in student-age female dancers.
THE INFLUENCE OF STRENGTH ON THE RESULTS OF THE VORTEX THROW
Authors: Stanković Daniel , Šućur Jelena , Raković Aleksandar
Published: August 2020

The aim of this paper was to determine the influence of strength on the results of the vortex throw. The research was carried out on a sample of 50 children aged 7 to 10, using the following measuring instruments for the evaluation of strength: the standing long jump, throwing a medicine ball from a supine position, torso lifts for 30 s knees bent, the plank and hanging leg raises. The research also included one measuring instrument for the evaluation of the distance in the vortex throw (the criterion variable). Based on the obtained results, it can be concluded that strength has a statistically significant influence on the results of the vortex throw among children aged 7 to 10 with a shared variability of approximately 43%. The greatest part of this significance can be ascribed to the tests of the medicine ball throw from a supine position which is responsible for the evaluation of the strength of the arms and shoulder belt. There were also significant correlations of the variables the standing long jump and torso lifts for 30 s knees bent with the result in vortex throw, but they did not significantly affect the results for this age group.