bluuebunny/crossref_metadata_2025 huggingface dataset:
Antibacterial potential of Propolis: molecular docking, simulation and toxicity analysis
Authors: Islam Shabana , Hussain Erum Akbar , Shujaat Shahida , Khan Muhammad Umer , Ali Qurban , Malook Saif Ul , Ali Daoud
Published: July 2024

The issue of antibiotic resistance in pathogenic microbes is a global concern. This study was aimed to explore in silico and in vitro analysis of the antibacterial efficacy of different natural ligands against bacterial activity. The ligands included in the study were Propolis Neoflavanoide 1, Carvacrol, Cinnamaldehyde, Thymol, p-benzoquinone, and Ciprofloxacin (standard drug S*). The outcomes of molecular docking revealed that Propolis Neoflavaniode-1 showed a highly significant binding energy of − 7.1 and − 7.2 kcal/mol for the two gram-positive bacteria, as compared to the gram-negative bacteria. All ligands demonstrated acute toxicity (oral, dermal), except for Propolis Neoflavanoide 1 and S* drugs, with a confidence score range of 50–60%. Using a molecular dynamic simulation approach, we investigated Propolis Neoflavaniode-1’s potential for therapeutic use in more detail. An MD simulation lasting 100 ns was performed using the Desmond Simulation software to examine the conformational stability and steady state of Propolis Neoflavaniode-1 in protein molecule complexes. Additionally, in vitro studies confirmed the antimicrobial activity of Propolis Neoflavaniode 1 by increasing the zone of inhibition against Gram-positive bacteria, p < 0.005 as compared to gram-negative bacteria. This study revealed the promising antibacterial efficacy of Propolis Neoflavaniode 1, demonstrated through robust in silico analyses, minimal toxicity, and confirmed in vitro antimicrobial activity, suggesting its potential as a viable alternative to combat antibiotic resistance.
Frame-based block sparse compressed sensing via $$l_2/l_1$$-synthesis
Authors: Wu Fengong , Zhong Penghong , Xiao Huasong , Miao Chunmei
Published: July 2024

In this paper, we consider the frame-based block sparse signal recovery via a$$l_2/l_1$$l2/l1-synthesis method. A new kind of null space property based on the given dictionaryD(blockD-NSP) is proposed. It is proved that sensing matrices satisfying the blockD-NSP is not just a sufficient and necessary condition for the$$l_2/l_1$$l2/l1-synthesis method to exactly recover signals that are block sparse in frameD, but also a sufficient and necessary condition for the$$l_2/l_1$$l2/l1-synthesis to stably recover signals which are block-compressible in frameD. To the best of our knowledge, this new property is the first sufficient and necessary condition for successful signal recovery via the$$l_2/l_1$$l2/l1-synthesis. In addition, we also characterize the theoretical performance of recovering signals via the$$l_2/l_1$$l2/l1-synthesis in the case of the measurements are disturbed.
Synthesis, biochemistry, and in silico investigations of isatin-based hydrazone derivatives as monoamine oxidase inhibitors
Authors: Maliyakkal Naseer , Oh Jong Min , Kumar Sunil , Gahori Prashant , Tengli Anandkumar , Beeran Asmy Appadath , Kim Hoon , Mathew Bijo
Published: July 2024

Ten isatin-based hydrazone derivatives were synthesized using two subseries, IA (isatin + acetophenone) and IB (isatin + benzaldehyde), and evaluated for their monoamine oxidases (MAOs) inhibitory activity. All the compounds showed stronger MAO-A inhibition than MAO-B, and the IB series showed more effective MAO-A inhibitory activity than IA series. Compound IB4 most potently inhibited MAO-A (half maximal inhibitory concentration IC50 = 0.015 µM), followed by IB3 (IC50 = 0.019 µM). On the contrary, compound IB3 showed the highest MAO-B inhibition (IC50 = 0.068 µM), followed by IB4 (IC50 = 1.87 µM). Compound IB3 and IB4 had low selectivity indices of 3.68 and 8.50, respectively. Structurally, the methyl group of IA series decreased the inhibition of both MAO-A and MAO-B. Among them, IB3 and IB4 (4-Cl and 4-Br in B-ring, respectively) showed higher MAO-A and MAO-B inhibition than the other substitutions. Inhibition constant Ki values of IB3 and IB4 for MAO-A were 0.0088 and 0.0063 µM, respectively, and those for MAO-B were 0.048 and 0.060 µM, respectively. IB3 and IB4 were competitive, reversible inhibitors of MAO-A and MAO-B. Molecular docking analysis predicted that IB3 and IB4 formed stable hydrogen bonds between Asn181 and the NH atom of isatin in the ligand-protein complex. Dynamic analysis revealed that IB3 and IB4 are stable with both MAO isoforms. These observations suggest IB3 and IB4 are potent and reversible MAO-A and MAO-B inhibitors and both compounds can be used as therapeutic agents for neurological disorders.
Versatile function of NF-ĸB in inflammation and cancer
Authors: Ma Qiang , Hao Shuai , Hong Weilong , Tergaonkar Vinay , Sethi Gautam , Tian Yu , Duan Chenyang
Published: July 2024

Nuclear factor-kappaB (NF-ĸB) plays a crucial role in both innate and adaptive immune systems, significantly influencing various physiological processes such as cell proliferation, migration, differentiation, survival, and stemness. The function of NF-ĸB in cancer progression and response to chemotherapy has gained increasing attention. This review highlights the role of NF-ĸB in inflammation control, biological mechanisms, and therapeutic implications in cancer treatment. NF-ĸB is instrumental in altering the release of inflammatory factors such as TNF-α, IL-6, and IL-1β, which are key in the regulation of carcinogenesis. Specifically, in conditions including colitis, NF-ĸB upregulation can intensify inflammation, potentially leading to the development of colorectal cancer. Its pivotal role extends to regulating the tumor microenvironment, impacting components such as macrophages, fibroblasts, T cells, and natural killer cells. This regulation influences tumorigenesis and can dampen anti-tumor immune responses. Additionally, NF-ĸB modulates cell death mechanisms, notably by inhibiting apoptosis and ferroptosis. It also has a dual role in stimulating or suppressing autophagy in various cancers. Beyond these functions, NF-ĸB plays a role in controlling cancer stem cells, fostering angiogenesis, increasing metastatic potential through EMT induction, and reducing tumor cell sensitivity to chemotherapy and radiotherapy. Given its oncogenic capabilities, research has focused on natural products and small molecule compounds that can suppress NF-ĸB, offering promising avenues for cancer therapy.
Papillary tumor of the pineal region: analysis of DNA methylation profiles and clinical outcomes in 76 cases
Authors: Wu Zhichao , Dazelle Karen , Abdullaev Zied , Chung Hye-Jung , Dahiya Sonika , Wood Matthew , Lee Han , Lucas Calixto-Hope G. , Mao Qinwen , Robinson Lorraina , Fernandes Igor , McCord Matthew , Pytel Peter , Conway Kyle S. , Yoda Rebecca , Eschbacher Jennifer M. , Maher Ossama M. , Hasselblatt Martin , Mobley Bret C. , Raisanen Jack M. , Hatanpaa Kimmo J. , Byers Joshua , Lehman Norman L. , Cimino Patrick J. , Pratt Drew , Quezado Martha , Aldape Kenneth
Published: July 2024

Papillary tumor of the pineal region (PTPR) is an uncommon tumor of the pineal region with distinctive histopathologic and molecular characteristics. Experience is limited with respect to its molecular heterogeneity and clinical characteristics. Here, we describe 39 new cases and combine these with 37 previously published cases for a cohort of 76 PTPR’s, all confirmed by methylation profiling. As previously reported, two main methylation groups were identified (PTPR-A and PTPR-B). In our analysis we extended the subtyping into three subtypes: PTPR-A, PTPR-B1 and PTPR-B2 supported by DNA methylation profile and genomic copy number variations. Frequent loss of chromosome 3 or 14 was found in PTPR-B1 tumors but not in PTPR-B2. Examination of clinical outcome showed that nearly half (14/30, 47%) of examined patients experienced tumor progression with significant difference among the subtypes (p value = 0.046). Our analysis extends the understanding of this uncommon but distinct neuroepithelial tumor by describing its molecular heterogeneity and clinical outcomes, including its tendency towards tumor recurrence.
NTRK-fused central nervous system tumours: clinicopathological and genetic insights and response to TRK inhibitors
Authors: Kim Eric Eunshik , Park Chul-Kee , Kim Seung-Ki , Phi Ji Hoon , Paek Sun Ha , Choi Jung Yoon , Kang Hyoung Jin , Lee Joo Ho , Won Jae Kyung , Yun Hongseok , Park Sung-Hye
Published: July 2024

Background Neurotrophic tropomyosin receptor kinase (NTRK) gene fusions are found in 1% of gliomas across children and adults. TRK inhibitors are promising therapeutic agents for NTRK-fused gliomas because they are tissue agnostic and cross the blood–brain barrier (BBB). Methods We investigated twelve NGS-verified NTRK-fused gliomas from a single institute, Seoul National University Hospital. Results The patient cohort included six children (aged 1–15 years) and six adults (aged 27–72 years). NTRK2 fusions were found in ten cerebral diffuse low-grade and high-grade gliomas (DLGGs and DHGGs, respectively), and NTRK1 fusions were found in one cerebral desmoplastic infantile ganglioglioma and one spinal DHGG. In this series, the fusion partners of NTRK2 were HOOK3, KIF5A, GKAP1, LHFPL3, SLMAP, ZBTB43, SPECC1L, FKBP15, KANK1, and BCR, while the NTRK1 fusion partners were TPR and TPM3. DLGGs tended to harbour only an NTRK fusion, while DHGGs exhibited further genetic alterations, such as TERT promoter/TP53/PTEN mutation, CDKN2A/2B homozygous deletion, PDGFRA/KIT/MDM4/AKT3 amplification, or multiple chromosomal copy number aberrations. Four patients received adjuvant TRK inhibitor therapy (larotrectinib, repotrectinib, or entrectinib), among which three also received chemotherapy (n = 2) or proton therapy (n = 1). The treatment outcomes for patients receiving TRK inhibitors varied: one child who received larotrectinib for residual DLGG maintained stable disease. In contrast, another child with DHGG in the spinal cord experienced multiple instances of tumour recurrence. Despite treatment with larotrectinib, ultimately, the child died as a result of tumour progression. An adult patient with glioblastoma (GBM) treated with entrectinib also experienced tumour progression and eventually died. However, there was a successful outcome for a paediatric patient with DHGG who, after a second gross total tumour removal followed by repotrectinib treatment, showed no evidence of disease. This patient had previously experienced relapse after the initial surgery and underwent autologous peripheral blood stem cell therapy with carboplatin/thiotepa and proton therapy. Conclusions Our study clarifies the distinct differences in the pathology and TRK inhibitor response between LGG and HGG with NTRK fusions.
New perspectives, additions, and amendments to plant endemism in a North African flora
Authors: Abd El-Ghani Monier , Hosni Hasnaa , Shamso Eman , Ellmouni Faten
Published: July 2024

Background

Endemism is essential in biodiversity, biogeography, and conservation tasks. Based on herbarium specimens kept in some local herbaria, many published literature, and available information, we compiled a comprehensive list and an updated assessment of the Egyptian endemic and near-endemic taxa. The application of quantitative approaches to the distribution patterns, conservation status, and habitat preference of endemic taxa in Egypt was provided. Comparisons of the near-endemic taxa with other neighbouring flora were explained. For each taxon, the distribution patterns, most preferable habitat, biological spectrum, and taxa among 14 phytogeographical regions (Operational Geographical Units; OGUs) of Egypt were determined.

Results

In this study, 19 endemics (out of 70) and 76 near-endemics (out of 181) are newly added taxa. Differentiation indices represented the taxonomic degrees of differentiation among endemic taxa. Two different indices were used to assess endemism: single-region endemic taxa (SRET) and multiple-region endemic taxa (MRET). Most endemic and near-endemic taxa were recorded from the mountainous Sinai (S) and the Mareotis sector of the Mediterranean coastal land (Mm). Generally, the most represented families in endemic and near-endemic areas were Asteraceae, Caryophyllaceae, Lamiaceae, and Fabaceae. More than 60% of the endemic taxa occurred in the sandy plains, wadis (desert valleys), and rocky plains and mountains. Applying hierarchical cluster analysis to the occurrences of 70 endemic taxa in the 14 studied OGUs revealed five main floristic groups (I–V), each characterized by certain OGUs. We provided eight groups of near-endemic taxa that represented their extension in neighbouring countries.

Conclusions

The presented data will help to fill the gap in our knowledge of endemism, provide baseline information to understand biogeographical processes and facilitate further cooperation toward conservation purposes.
Effects of thermophilic and acidophilic microbial consortia on maize wet-milling steeping
Authors: Sun Yaqin , Xia Wenjing , Tang Langjun , Xiu Zhilong , Jin Weiwu , Wang Xiaoyan , Tao Jin , Liu Haijun , An Hongyan , Li Yi , Tong Yi
Published: July 2024

To understand the ecology of species and promote biotechnology through beneficial strain selection for improving starch yield in maize wet-milling steeping, bacterial diversity and community structure during the counter-current steeping process in a commercial steeping system were characterized and investigated. The microbial diversity in the steeping liquor, which consisted of 16 phyla, 131 families, and 290 genera, was more abundant compared to those present on the surface of unsteeped maize. As the counter-current steeping progressed, exposing newer maize to the older steepwater, Lactobacillus dominated, replacing Rahnella, Pseudomonas, Pantoea, and Serratia. The thermophilic and acidophilic microbial consortia were enriched through adaptive evolution engineering and employed to improve starch yield. Several steeping strategies were evaluated, including water alone, SO2 alone, mono-culture of B. coagulans, microbial consortia, and a combination of consortium and SO2. Combining the microbial consortium with SO2 significantly increased the starch yield to, about 66.4 ± 0.5%, a 22% and 46% increase over SO2 alone and the consortium alone, respectively. Scanning electron microscope (SEM) of steeped maize structure indicated that the combination of consortium and SO2 disrupted the protein matrix and widened gaps between starch granules in maize endosperm. This released proteins into the steepwater and left starch granules in the aleurone layer. The steeping strategy of using thermophilic and acidophilic microbial consortium as additives shows potential application as an environmentally friendly alternative to conventional maize steeping procedures.
Influence of temperature on the compression properties of expanded thermoplastic polyurethane (ETPU)
Authors: Meuchelböck Johannes , Peiffer Carlo , Walter Lena , Dippold Marcel , Munro Peter , Ruckdäschel Holger
Published: July 2024

This study explores how expanded thermoplastic polyurethane (ETPU) responds to temperature and compression at various temperatures. Dynamic mechanical thermal analysis (DMTA) was used to understand the temperature influence at small deformations. To investigate the deformation behavior at different compression stages we employed in-situ CT measurements and 3D strain mapping. Through quasi-static compression tests at temperatures from − 50 to 120 °C, we determined the influence of temperature on compression modulus, elastic stress, stress at 50% deformation, densification, and energy absorption. Remarkably, ETPU demonstrates robust recovery after compression, particularly within the − 50 to 60 °C temperature range. Subsequent compression tests show consistent or even slightly increased compression properties, such as a 10% increase in energy absorption for samples previously tested at − 40 °C, indicating that ETPU can withstand prior exposure to different temperatures.
Deep learning systems for forecasting the prices of crude oil and precious metals
Authors: Foroutan Parisa , Lahmiri Salim
Published: July 2024

Commodity markets, such as crude oil and precious metals, play a strategic role in the economic development of nations, with crude oil prices influencing geopolitical relations and the global economy. Moreover, gold and silver are argued to hedge the stock and cryptocurrency markets during market downsides. Therefore, accurate forecasting of crude oil and precious metals prices is critical. Nevertheless, due to the nonlinear nature, substantial fluctuations, and irregular cycles of crude oil and precious metals, predicting their prices is a challenging task. Our study contributes to the commodity market price forecasting literature by implementing and comparing advanced deep-learning models. We address this gap by including silver alongside gold in our analysis, offering a more comprehensive understanding of the precious metal markets. This research expands existing knowledge and provides valuable insights into predicting commodity prices. In this study, we implemented 16 deep- and machine-learning models to forecast the daily price of the West Texas Intermediate (WTI), Brent, gold, and silver markets. The employed deep-learning models are long short-term memory (LSTM), BiLSTM, gated recurrent unit (GRU), bidirectional gated recurrent units (BiGRU), T2V-BiLSTM, T2V-BiGRU, convolutional neural networks (CNN), CNN-BiLSTM, CNN-BiGRU, temporal convolutional network (TCN), TCN-BiLSTM, and TCN-BiGRU. We compared the forecasting performance of deep-learning models with the baseline random forest, LightGBM, support vector regression, and k-nearest neighborhood models using mean absolute error (MAE), mean absolute percentage error, and root mean squared error as evaluation criteria. By considering different sliding window lengths, we examine the forecasting performance of our models. Our results reveal that the TCN model outperforms the others for WTI, Brent, and silver, achieving the lowest MAE values of 1.444, 1.295, and 0.346, respectively. The BiGRU model performs best for gold, with an MAE of 15.188 using a 30-day input sequence. Furthermore, LightGBM exhibits comparable performance to TCN and is the best-performing machine-learning model overall. These findings are critical for investors, policymakers, mining companies, and governmental agencies to effectively anticipate market trends, mitigate risk, manage uncertainty, and make timely decisions and strategies regarding crude oil, gold, and silver markets.
Subcarrier modulated navigation signal processing in GNSS: a review
Authors: Yao Zheng , Qi Yunhan , Lu Mingquan
Published: July 2024

Subcarrier modulated signals are widely used in the new generation of Global Navigation Satellite Systems (GNSS) to improve spectral compatibility and ranging accuracy. The unique structure of subcarrier modulated signals poses an ambiguity threat to acquisition and tracking, rendering traditional GNSS signal processing algorithms unsuitable. Designing unambiguous acquisition and tracking as well as observation extraction techniques for subcarrier modulated signals that can realize the high ranging accuracy potential while avoiding the ambiguity threat is a topic of common interest in both academia and industry. Numerous studies have addressed the ambiguity elimination problem of subcarrier modulated signals. However, to the best of our knowledge, no updated reviews on this topic reflecting recent advances in the field have been presented in the past few years. On the one hand, the unique composite subcarrier modulated signal structure in the B1 and B2 bands of the BeiDou Navigation Satellite System (BDS) and the E5 band of the Galileo satellite navigation system (Galileo) has been gradually emphasized by academics. On the other hand, unambiguous processing methods for subcarrier modulated signals based on multidimensional tracking loops have flourished, which provides a new way to solve the ambiguity problem. An overview of the most representative subcarrier modulated signal processing techniques, focusing on the achievements made in the last decade, is presented in this article, which can be a starting point for the researchers who start their study in this area. Furthermore, we aim to present a complete review on the recent breakthroughs that have taken place within this research area, providing links to the most interesting and successful advances in this research field. Remaining challenges with prospects are also given.
Assessing the potential integration of large language models in accounting practices: evidence from an emerging economy
Authors: Toumeh Ahmad A.
Published: July 2024

This research intends to demonstrate the potential integration of large language models (LLMs) in accounting practices in Jordan. It is a mixed methods study that employs semi-structured interviews and content analysis of published financial reports. A total of 13 semi-structured interviews are conducted with various accounting professionals, such as accountant, financial analyst, financial controller, auditor, tax consultant, and finance manager. In addition, the study includes a thorough content analysis of financial reports, which reveals a compelling pattern highlighting the distinct narrative content richness prevalent across financial, industrial, and service sectors. The results emphasize the need for sector-specific adaptation, suggesting a paradigm shift in financial reporting practices. This study represents the initial empirical exploration in Jordan. It serves as a bridge between theory and application, offering both theoretical insights and practical guidance for accounting professionals. Ultimately, the study envisions a future where LLMs significantly enrich financial reporting practices across diverse sectors.
m6A-dependent mature miR-151-5p accelerates the malignant process of HNSCC by targeting LYPD3
Authors: Huang Fei , Ren Yuan , Hua Yufei , Wang Ying , Li Ruomeng , Ji Ning , Zeng Xin , Bai Ding , Chen Qianming , Zhou Xikun , Wu Junjie , Li Jing
Published: July 2024

miRNA has emerged as a crucial regulator in various of pathological and physiological processes, yet its precise mechanism of action the detailed mechanism of their action in Head and neck squamous cell carcinoma (HNSCC) remains incompletely understood. This study sheds light on the role of mi-151-5p, revealing its significantly elevated expression in tumor cells, which notably enhances the invasion and migration of HNSCC cells. This effect is achieved through directly targeting LY6/PLAUR Domain Containing 3 (LYPD3) by miR-151-5p, involving complementary binding to the 3’-untranslated regions (3’-UTR) in the mRNA of LYPD3. Consequently, this interaction accelerates the metastasis of HNSCC. Notably, clinical observations indicate a correlation between high expression of miR-151-5p and low levels of LYPD3 in clinical settings are correlated with poor prognosis of HNSCC patients. Furthermore, our investigation demonstrates that glycosylation of LYPD3 modulates its subcellular localization and reinforces its role in suppressing HNSCC metastasis. Additionally, we uncover a potential regulatory mechanism involving the facilitation of miR-151-5p maturation and accumulation through N6-methyladenosine (m6A) modification. This process is orchestrated by methyltransferase-like 3 (METTL3) and mediated by a newly identified reader, heterogeneous nuclear ribonucleoprotein U (hnRNP U). These findings collectively underscore the significance of the METTL3/miR-151-5p/LYPD3 axis serves as a prominent driver in the malignant progression of HNSCC.
Diversification of FT-like genes in the PEBP family contributes to the variation of flowering traits in Sapindaceae species
Authors: Huang Xing , Liu Hongsen , Wu Fengqi , Wei Wanchun , Zeng Zaohai , Xu Jing , Chen Chengjie , Hao Yanwei , Xia Rui , Liu Yuanlong
Published: July 2024

Many species of Sapindaceae, such as lychee, longan, and rambutan, provide nutritious and delicious fruit. Understanding the molecular genetic mechanisms that underlie the regulation of flowering is essential for securing flower and fruit productivity. Most endogenous and exogenous flowering cues are integrated into the florigen encoded by FLOWERING LOCUS T. However, the regulatory mechanisms of flowering remain poorly understood in Sapindaceae. Here, we identified 60 phosphatidylethanolamine-binding protein-coding genes from six Sapindaceae plants. Gene duplication events led to the emergence of two or more paralogs of the FT gene that have evolved antagonistic functions in Sapindaceae. Among them, the FT1-like genes are functionally conserved and promote flowering, while the FT2-like genes likely serve as repressors that delay flowering. Importantly, we show here that the natural variation at nucleotide position − 1437 of the lychee FT1 promoter determined the binding affinity of the SVP protein (LcSVP9), which was a negative regulator of flowering, resulting in the differential expression of LcFT1, which in turn affected flowering time in lychee. This finding provides a potential molecular marker for breeding lychee. Taken together, our results reveal some crucial aspects of FT gene family genetics that underlie the regulation of flowering in Sapindaceae.
Exome Sequencing Identifies Carriers of the Autosomal Dominant Cancer Predisposition Disorders Beyond Current Practice Guideline Recommendations
Authors: Samadder N. Jewel , Gay Emily , Lindpere Vanda , Bublitz Michelle L. , Bandel Lorelei A. , Armasu Sebastian M. , Vierkant Robert A. , Ferber Matthew J. , Klee Eric W. , Larson Nicholas B. , Kruisselbrink Teresa M. , Egan Jan B. , Kemppainen Jennifer L. , Bidwell Jessa S. , Anderson Jennifer L. , McAllister Tammy M. , Walker T'Nita S. , Kunze Katie L. , Golafshar Michael A. , Klint Margaret A. , Presutti Richard J. , Bobo William V. , Sekulic Aleksander , Summer-Bolster Jolene M. , Willman Cheryl L. , Lazaridis Konstantinos N.
Published: July 2024

PURPOSE

The autosomal dominant cancer predisposition disorders hereditary breast and ovarian cancer (HBOC) and Lynch syndrome (LS) are genetic conditions for which early identification and intervention have a positive effect on the individual and public health. The goals of this study were to determine whether germline genetic screening using exome sequencing could be used to efficiently identify carriers of HBOC and LS.

METHODS

Participants were recruited from three geographically and racially diverse sites in the United States (Rochester, MN; Phoenix, AZ; Jacksonville, FL). Participants underwent Exome+ sequencing (Helix Inc, San Mateo, CA) and return of results for specific genetic findings: HBOC ( BRCA1 and BRCA1) and LS ( MLH1, MSH2, MSH6, PMS2, and EPCAM). Chart review was performed to collect demographics and personal and family cancer history.

RESULTS

To date, 44,306 participants have enrolled in Tapestry. Annotation and interpretation of all variants in genes for HBOC and LS resulted in the identification of 550 carriers (prevalence, 1.24%), which included 387 with HBOC (27.2% BRCA1, 42.8% BRCA2) and 163 with LS (12.3% MSH6, 8.8% PMS2, 4.5% MLH1, 3.8% MSH2, and 0.2% EPCAM). More than half of these participants (52.1%) were newly diagnosed carriers with HBOC and LS. In all, 39.2% of HBOC/LS carriers did not satisfy National Comprehensive Cancer Network (NCCN) criteria for genetic evaluation. NCCN criteria were less commonly met in underrepresented minority populations versus self-reported White race (51.5% v 37.5%, P = .028).

CONCLUSION

Our results emphasize the need for wider utilization of germline genetic sequencing for enhanced screening and detection of individuals who have LS and HBOC cancer predisposition syndromes.
Increase in Testosterone Levels and Improvement of Clinical Symptoms in Eugonadic men With a Prolactin-secreting Adenoma
Authors: Carlier Lea , Chanson Philippe , Cazabat Laure , Daclin Sylvie , Salenave Sylvie , Hage Mirella , Trabado Séverine , Young Jacques , Maione Luigi
Published: July 2024

Objective

Testosterone concentrations, albeit rarely, may be in the normal range (>3.0 ng/mL) in men with a prolactin-secreting pituitary adenoma (PSPA-nt). The evolution of total, bioavailable testosterone, gonadotropin levels, and that of graded symptoms of testosterone deficiency (TD) are uncertain in these patients.

Design

Retrospective case-control longitudinal study at a tertiary referral center.

Methods

From 287 men, we selected 25 PSPA-nt men undergoing prolactin normalization (<20.0 ng/mL) during the follow-up. Graded symptoms of TD were investigated by structured interviews. Biochemical changes and TD symptoms were compared to those of a matched cohort of 61 men with pituitary neoplasms and normal testosterone levels (PA-nt).

Results

Baseline testosterone levels were similar between PSPA-nt and PA-nt subjects. The prevalence of specific and suggestive symptoms of TD was higher in PSPA-nt (20% and 68%) than in PAnt (3.3 and 29.5%; P = .02 and P = .0015, respectively). At the follow-up, total and bioavailable testosterone levels increased in PSPA-nt but not in PA-nt patients (Δ change: 1.28 ± 2.1 vs0.03 ± 1.5 ng/mL, + 0.33 ± 0.55 vs-0.26 ± 0.60 ng/mL; P = .0028 and P = .0088, respectively). LH and FSH levels also increased in PSPA-nt men (P < .05). Specific and suggestive, but not nonspecific symptoms of TD, improved only in PSPA-nt men (P < .05 for both). Baseline testosterone and LH were the strongest predictors of testosterone improvement in PSPA-nt patients.

Conclusion

Despite having normal testosterone levels at baseline, patients with PSPA-nt experience a relief of TD symptoms and an improvement of their pituitary-gonadal axis function following prolactin normalization, especially when baseline TT and LH levels are in the low-normal range.
Who Divorces Whom: Unilateral Divorce Legislation and the Educational Structure of Marriage
Authors: Afunts Geghetsik , Jurajda Stepan
Published: July 2024

The introduction of unilateral divorce legislation (UDL) starting in the late 1960s led to spikes in U.S. divorce rates. We ask whether making divorce easier affected the educational structure of marriage. Using marriage and divorce certificate data covering 1970–1988, we provide new evidence on the evolution of the educational structure of marriage inflows (newlyweds) and outflows (divorces). Next, we leverage the timing of UDL introduction across states to estimate its effects on both flows. We find that UDL affected the educational structure of divorce but not of new marriages: it made generally unstable hypogamous couples (women married to less educated partners) less likely to divorce and made homogamous couples more stable than hypergamous ones (women married to more educated partners).
Ho‘ailona
Authors: Otjen Nathaniel
Published: July 2024

This article asks what it means for conservation scientists to label a member of an endangered, endemic species homeless. By considering the boundary-crossing figure of Ho‘ailona, a partially blind Hawaiian monk seal who was declared homeless and translocated six times between 2008 and 2009, the article argues that the language of home points to the ongoing operations of colonialism in Western conservation. Reading the discourse of homelessness offers a methodology for tracing the histories and manifestations of colonial logics as they circulate in conservation science. At the same time, the article considers how Kānaka Maoli articulated a contrapuntal claim to home that positioned Ho‘ailona as belonging in his natal waters and among a multispecies community of caregivers. Bringing together critical homelessness studies and settler colonial studies, the essay examines how settler societies and institutions use endangered marine species to make specific claims to home and, by extension, erase Indigenous claims to place.
Uncertain Waters and Irony in Australian Settler Literatures
Authors: Shewry Teresa , Steer Philip
Published: July 2024

Critics are increasingly recognizing the presence of irony in environmental cultures, often stressing its ability to highlight disjunctions between the individual’s convictions and their compromised behaviors. This article extends this work by taking up the relationship between irony and settler-colonial imaginaries in writings about unpredictable bodies of water. Focusing on settler writing in Australia, the article juxtaposes nineteenth-century author Henry Lawson and contemporary novelist Jane Rawson to argue that irony constitutes a form of environmental knowledge, calling up norms and hierarchies regarding water but also creating openings toward waters that cannot be given meaning. Lawson’s writings about ephemeral rivers and lakes stress their divergence from metropolitan ideas of water’s continuity, presence, and visibility. Largely ignoring Indigenous peoples’ relationships with water, his ironies of overturned expectations and norms make contact with but also disparage water in unfamiliar forms. By contrast, Rawson’s A Wrong Turn at the Office of Unmade Lists (2013) employs irony to grasp how climate-changed floodwater disrupts settler norms founded upon the erasure of floodplains and of Indigenous and colonial histories of urban rivers. Juxtaposing Rawson with Lawson illuminates an ongoing need to be cautious about the ideals that irony may evoke in response to changing and uncertain waters. At the same time, irony provides a multivalent tool to critically address what Mark Rifkin calls “settler common sense,” to glimpse the persistence of Indigenous knowledge and perspectives, and to acknowledge occluded forms of environmental agency.
Death anxiety scale (DAS): internal structure and factorial invariance in Peruvian adults
Authors: De La Cruz-Valdiviano Carlos , Bazán-Ramirez Aldo , Olivas-Ugarte Lincol , Quijano-Pacheco Juan
Published: July 2024

Background Studies have this reported the presence of death anxiety, ranging from near-death experiences to physically ill people, to a simple thought about death, as well as when it is associated with states of loneliness. The Templer’s Death Anxiety Scale (DAS), based on Eysenk’s incubation theory, has been adapted and validated in different contexts and is still insufficient in countries such as Peru. This study aimed to determine the psychometric properties of the DAS, its internal structure, and factorial invariance. Methods An online scale was used in 1248 Peruvians aged between 18 and 70 years (M= 27.37, SD= 11.29) from all regions. DAS was validated using exploratory factor analysis (EFA), confirmatory factor analysis (CFA), convergent validity, measurement invariance, and internal consistency (reliability). Results Psychometric properties were found with adequate values in its structure and validity based on the internal structure through exploratory factor analysis, where it was found that the components of the scale are interrelated and the data matrix is factorizable. model of three specific factors and a general factor is presented, which is consistent with the theory and has practical utility, revealing adequate statistical values that reflect acceptable levels of reliability. Finally, there was fairness according to sex and age group of the scale by means of factorial invariance analysis. Conclusions Our results indicate adequate psychometric properties and facilitate a better data collection process for future research.
Beyond stroke therapy, neuroaid (a chinese herbal) has an effect on cognition and neurogenesis, a bibliometric study
Authors: SALEH ARMAN YURISALDI , Valentina Riezky , Susanto Tirta Darmawan , Saputra Dwi Arwandi Yogi
Published: July 2024

Introduction NeuroAiD, also known as MLC601 or MLC901, is a Chinese herbal combination used worldwide for stroke treatment. It contains herbal components and five hewan components. MLC601 contains herbal components and hewan components, while MLC901 has a similar herbal composition. NeuroAiD is used to support neurologic recovery after stroke and to aid cognitive function in Alzheimer’s disease. Studies show that NeuroAiD has potential in treating Alzheimer’s disease and is beneficial in both local and global stroke models and in the Kortikal culture. However, there is limited bibliometric research on NeuroAiD, which is a method of collecting data from published articles to analyze developments and trends in the field of research. This research contributes significantly to the literature and helps develop more effective stroke treatment strategies. Methods In this work, a literature review methodology is employed to gather data from the Scopus database using the keywords neuroaid. Data were analyzed using Biblioshiny and VOSviewer software to produce visualizations and bibliometric maps. We conducted quantitative and qualitative analysis Results The research trend found are documents by year, most relevant sources, factorial map of the most cited documents, factorial map of The documents with the highest contributes, documents by author, documents by country or territory, documents by subject area, documents by affiliation, network visualization, overlay visualization of scopus database using vosviewer, density visualization, thematic map, thematic evolution, topic dendogram, and world cloud. Conclusions The study investigates the potential of Neuroaid, a neuroprotective drug, for stroke prevention and cognitive function enhancement. It uses terms like “cognition” and “neurogenesis” to highlight its potential. While the study’s focus may be limited, it provides valuable insights into research direction and potential areas of neuroaid for stroke treatment.
Hypoxic Preconditioning Promotes Survival of Human Adipose Derived Mesenchymal Stem Cell
Authors: Suryawan I Gde Rurus , Pikir Budi Susetyo , Rantam Fedik Abdul , Ratri Anudya Kartika , Nugraha Ricardo Adrian
Published: July 2024

Background: Contributing factors for improved survival of human adipocytes mesenchymal stem cells (h-AMSCs) cultured through hypoxia preconditioning, in example apoptosis inhibition involving BCL2 and HSP27 expression, trigger signal expression (VEGF), SCF expression, OCT-4 expression, and CD44+ expression. The objective if this study was to explain the mechanism and role of hypoxic preconditioning and the optimal duration of hypoxic preconditioning exposure to improve survival of h-AMSCs. Methods: An experimental laboratory explorative study (in vitro) with hypoxic preconditioning in h-AMSCs cultures. This research was conducted through four stages. First, isolation of h-AMSCs culture from adipose tissue of patients. Second, the characterization of h-AMSCs from adipose tissue by phenotype (flowcytometry) through CD44+, CD90+ and CD45-expression before being pre-conditioned for hypoxic treatment. Third, the hypoxic preconditioning in h-AMSCs culture (in vitro) was performed with an oxygen concentration of 1% for 24, 48 and 72 hours. Fourth, observation of survival from h-AMSCs culture was tested on the role of CD44+, VEGF, SCF, OCT-4, BCL2, HSP27 with Flowcytometry and apoptotic inhibition by Tunnel Assay method. Results: The result of regression test showed that time difference had an effect on VEGF expression (p<0.001;β=-0.482) and hypoxia condition also influenced VEGF expression (p<0.001;β=0.774). The result of path analysis showed that SCF had effect on OCT-4 expression (p<0.001; β=0.985). The regression test results showed that time effects on HSP27 expression (p<0.001; β=0.398) and hypoxia precondition also affects HSP27 expression (p<0.001; β=0.847). Pathway analysis showed that BCL2 expression inhibited apoptosis (p=0.030; β=-0.442) and HSP27 expression also inhibited apoptosis (p<0,001;β=-0.487). Conclusion: Hypoxic preconditioning of h-AMSC culture has proven to increase the expression of VEGF, SCF, OCT-4, and BCL2 and HSP27. This study demonstrated and explained the existence of a new mechanism of increased h-AMSC survival in cultures with hypoxic preconditioning (O2 1%) via VEGF, SCF, OCT-4, BCL2, and HSP 27.
Investor demand in syndicated EFSF/ESM bond issuances
Authors: Hillebrand Martin , Mravlak Marko , Schwendner Peter
Published: July 2024

The European Financial Stability Facility (EFSF) and the European Stability Mechanism (ESM) were set up at the peak of the European sovereign debt crisis to issue bonds and lend to countries under current funding stress. This study analyses investor demand in syndicated bond issuances of EFSF and ESM from 2014 to 2020 on an unprecedented granularity level using a dataset of individual orders with statistical inference. Particularly, we investigate orderbook dynamics for three main aspects: first, we determine the main factors segmenting investor demand. Second, we analyse price dynamics in the transactions and their relation to investor demand. Third, we investigate whether any indications of orderbook inflation might explain the increased volatility in orderbook volume. We identify issuance tranche and tenor as the main determinants of investor demand that are largely anticipated in the notional. Further, we note that ESM is doing economical pricing, where the new issue premium tends to be lower in a market context with larger demand. Lastly, we find a mixture of an increasing number and an increasing volume of orders as drivers of large order books. This confirms that there are no indications of orderbook inflation tendencies in the analysed time period.
Reconceptualizing learning loss: the need for trauma-informed and responsive care in K-12 education
Authors: Tran Annie Nguyen
Published: July 2024

Globally, the Coronavirus (COVID-19) pandemic immediately and drastically changed the norms of the K-12 education system when schools were forced to close to mitigate the spread of COVID-19. School closures forced educational collaborators to shift from in-person learning to a virtual platform. As a result, the sudden change to a different modality of teaching and learning contributed to the widening of the opportunity gap for students – particularly students from low socioeconomic statuses, English language learners, students with disabilities, and students whose academic and non-academic needs became inaccessible. With the opportunity gap continuing to expand, collaborators must consider the need for a different approach to address the academic and non-academic needs of students, as students and educators returned to in-person learning. This paper discusses how the pandemic contributed to global discussions on student learning loss and how there needs to be a reconceptualization of learning loss to understand how K-12 education can adapt to a new norm. School districts should consider the need for trauma-informed and responsive care to support students in re-engaging with their school community. The implementation of this level of care will allow students to heal while developing new social, emotional, and academic skills that they were unable to build upon as a result of the pandemic.
The genome sequence of the Mauritius parakeet, Alexandrinus eques (formerly Psittacula eques) (A.Newton & E. Newton, 1876)
Authors: Morales Hernán E. , Groombridge Jim J. , Tollington Simon , Henshaw Sion , Tatayah Vikash , Ruhomaun Kevin , van Oosterhout Cock , Gilbert M. Thomas P. ,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective
Published: July 2024

We present a genome assembly from an individual male Alexandrinus eques, formerly Psittacula eques (the Mauritius Parakeet; Chordata; Aves; Psittaciformes; Psittacidae). The genome sequence is 1203.8 megabases in span. Most of the assembly is scaffolded into 35 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 18.86 kilobases in length.
Understanding the barriers and facilitators of human papillomavirus vaccine uptake in Kwale and Mombasa counties in Kenya: A study protocol
Authors: Kiyuka Patience Kerubo , Gichuki Paul Muriithi , Nekesa Henderica , Okoyo Collins , Ouma Nelson , Mwangangi Joseph , Chi Primus Che , Njomo Doris
Published: July 2024

Background Cervical cancer poses a significant public health problem globally. Human papillomavirus (HPV) vaccination protects against HPV types 16 and 18, responsible for approximately 70% of cervical cancer cases. The optimal vaccination age is in the early adolescent period before sexual debut with possible HPV infection. In 2019, through the Ministry of Health, the Kenya government introduced the HPV vaccine to 10-14-year-old girls. However, analysis of the vaccine coverage across the counties shows that uptake is suboptimal. Our study proposes to apply the World Health Organization (WHO) Measuring Behavioural and Social Drivers (BeSD) of the vaccination framework to understand the barriers and facilitators of HPV vaccine uptake in two counties of Kenya. Methods The study design will be cross-sectional, utilising a mixed methods approach for data collection. We will sample 668 girls aged 10–14 years, across the two counties of Kwale and Mombasa and collect data using using an interviewer-administered questionnaire. Qualitative data will be collected through focus group discussions with CHEWs, and community leaders, and key informant interviews with nurses, clinical officers, vaccine program managers and national vaccine focal persons. We will use the WHO BeSDvaccination framework as our conceptual framework. Significance Understanding the barriers and facilitators for HPV vaccination will help in developing strategies to be applied for improving HPV vaccine uptake.
The effectiveness and health impact of fad diets on obese patients: a literature review
Authors: Kraszkiewicz Adrianna , Zaliwska Dominika , Paduszyńska Natalia , Dąbrowska Anna , Gonciarz Marta Justyna , Czach Magdalena , Strojny Agnieszka Aleksandra , Adamiec Dominika Karolina , Kamińska Monika Anna , Kienanh Do Monika
Published: July 2024

Introduction and purpose
Obesity is a serious health problem nowadays and it is becoming more and more common. There are plenty of causes of obesity including bad eating habits, genetic factors, and psychological factors. A lot of obese people look for a way to lose weight. Fad diets are popular dietary strategies which are promoted as a quick way to lose weight. This article highlights some popular dietary strategies including low-carbohydrate diet, low-fat diet, Paleolithic Diet and Detox Diet. The aim of this paper is to analyse their effectiveness in the process of successful weight loss and their health impact.
State of knowledge
According to WHO in 2022 1 in 8 people in the world were obese. Fad diets are promoted as methods to improve health and as a quick way to lose weight. However, available research suggests a rather unfavorable impact on human health in the context of long-term adherence to these diets. Limited data suggests the beneficial long-term health impact of such diets. Moreover, dieting and weight cycling caused by the repetitive process of weight loss after dieting and weight regain afterwards may also play a role in the development of obesity.
Conclusion
Fad diets are not recommended as a long-term way of nutrition. The main limitation of these dietary strategies is their short-term effectiveness rather than long-term. Adherence to these diets is hard for patients. Because of their strict rules and food exclusions, the risk of weight regain is high. Moreover, they do not show many positive long-term health consequences and they are not superior to conventional healthy diets. What’s more, strict obedience to fad diets for extended periods of time may be detrimental to the dieter's health.