bluuebunny/crossref_metadata_2025 huggingface dataset:
Testamentos de Palencia. Hombres y mujeres del ámbito rural en la segunda mitad del setecientos = Wills in Palencia. Men and women in the rural world in the second half of the eighteenth century
Authors: Quijada Sánchez Didio
Published: February 2020

El presente trabajo tiene como objetivo analizar el comportamiento diferenciado entre hombres y mujeres ante el hecho de la muerte y, por otro lado, examinar los testamentos del medio rural con la finalidad de comparar y contrastar conlos del ámbito urbanoThe purpose of this paper is to examine the differences in the behavior of men and women in relation to death as well as to compare rural and urban wills
Identidad, sobrecualificación y riesgos en trabajadores de empresas de externalización de servicios. Un estudio desde la antropología del trabajo
Authors: González González Miguel
Published: February 2020

Autor: Miguel González GonzálezDirector: Dr. Óscar Fernández ÁlvarezTesis doctoral defendida el 29 de enero de 2018La aplicación de los métodos de la Antropología cultural debe extenderse al estudio intensivo de las sociedades complejas e industriales y no solo al estudio de la evolución material de los llamados pueblos primitivos tal y como afirmaba Claudio Esteva Fabregat (1973). A través de la Antropología del trabajo podemos dar explicaciones complejas de las relaciones laborales, es decir, de la interacción entre actores individuales como son el trabajador y el empresario y colectivos, como son las asociaciones sindicales, patronales y su relación con el gobierno.  A través de la investigación cualitativa, utilizando el método etnográfico y el trabajo de campo nos introducimos en el sector del telemarketing, que es un modelo paradigmático de externalización de servicios, para desarrollar nuestra investigación y analizar las relaciones laborales del siglo XXI desde la perspectiva de la Antropología del Trabajo. La empresa es un espacio de relaciones, tanto formales como informales que se solapan entre los propios trabajadores y la propia empresa
Understanding Social Justice Engagement in Social Work Curriculum
Authors: Benner Kalea , Loeffler Dianne , Buchanan Steven
Published: February 2020

Understanding how undergraduate social work students learn knowledge and skills related to social justice is paramount to meeting the professional imperative of social justice in social work practice. However, there is no singular definition of social justice, nor is there consistency in how social justice is taught across social work curricula. Typically, social work programs either infuse social justice across the social work curriculum or require an in-depth, social justice content-driven course. These dual inconsistencies create challenges in understanding how students learn social justice. This study seeks to understand if undergraduate students have better outcomes related to knowledge and skill in a course structured with an in-depth social justice-–specific curriculum versus a course that has social justice infused across the content. Simply knowing how social justice curriculum is taught is not sufficient; rather, we must understand how social justice engagement is learned.
PROPERTIES OF WAVEFIELD EXTRAPOLATION OPERATORS (ON THE EXAMPLE OF PREDICTION OF GHOST REFLECTIONS)
Authors: Denisov M. S. , Egorov A. A.
Published: February 2020

Seismic deghosting algorithms involve wavefield extrapolation. The operator of such a transformation is integral, and when applied to discrete seismic data, its approximation is used, which corresponds to a method of numerical integration. The paper examines the limits of applicability of the approximation by the method of cells and the method of rectangles. It is shown that when processing 3D seismograms recorded using traditional survey geometries, correct ghost prediction is possible only after interpolation. When processing 2D seismic gathers, it is possible to predict and remove ghost waves for deep and shallow streamers. The streamer shape can be arbitrary. The results of the study and the conclusions made are valid not only for ghost prediction operators, but also for all seismic exploration tasks that involve wavefield extrapolation.
The Relationship of Food Security and Economical-Social Issues with Osteoporosis in Women Over 45 Years
Authors: Ahmadi Neshat , Movahedi Ariyo , Djazayeri Seyyed Abolghasem
Published: February 2020

Background: Today food security is one of the most important issues throughout the world. Every year, millions of people die due to the shortage of food and nutrient products. The current study aimed to investigate the effect of food security and economic-social issues on women over 45 years who referred to the Bone Density Assessment Center in Kermanshah City in 2015. Methods: A 9-item questionnaire was applied to collect the required data. The collected data were analyzed using the liner regression and Kruskal–Wallis one-way analysis of variance. Results: Bone density was significantly correlated with the participants' household size, number of children, history of menopause, familial history of osteoporosis, number of pregnancies, calcium supplementation, use of sunscreen, and reception of some food elements. Conclusion: Since economic and social issues play a critical role in food security, these cases can significantly affect the density of bones.
Seasonality of Acute Retinal Necrosis
Authors: Hedayatfar Alireza , Ashraf Khorasani Maryam , Behnia Mehdi , Sed-aghat Ahad
Published: February 2020

Purpose: To study the seasonal variability in the occurrence of acute retinal necrosis (ARN) in a series of polymerase chain reaction (PCR)-positive patients.
Methods: Consecutive patients clinically diagnosed with ARN and a positive PCR result of aqueous humor during a seven-year period were studied retrospectively. Patients’ demographics, causative viral agent(s), and the date of disease onset were extracted from medical records.
Results: Twenty eyes of 20 patients were enrolled; the mean age at presentation was 39.6 ± 14.4 (range, 6–62) years. Nine patients were female. The most common causative agent was varicella-zoster virus in 16 patients (80%), followed by herpes simplex virus in two patients (10%). The disease onset was in winter in 10 patients (50%), and the highest incidence was in February (five patients, 25%). The cumulative occurrence of ARN was significantly higher in the first half of the year (winter and spring) compared to the second half of the year (summer and fall) (P = 0.030). In general, seasons with a high incidence of ARN were preceded by cold seasons.
Conclusion: In our series, we observed seasonal variability in the incidence of ARN, with the highest incidence during winter and spring. However, further epidemiologic studies in different geographical areas are required to elucidate the true seasonal nature of ARN.
Intraorbital Steroid Injection for Active Thyroid Ophthalmopathy
Authors: Bagheri Abbas , Abbaszadeh Mohammad , Yazdani Shahin
Published: February 2020

Purpose: To evaluate the effect of orbital steroid injections in patients with active thyroid ophthalmopathy resistant to or dependent on systemic steroids, or with complications related to systemic steroid use.
Methods: This prospective non-comparative case series includes 31 eyes of 17 patients with active thyroid ophthalmopathy and clinical activity score (CAS) of 3 or more, without compressive optic neuropathy or overt exposure keratopathy. All subjects had a history of previous systemic steroid use (with steroid resistance or dependence) or had developed complications related to steroids. A combination of steroids including triamcinolone acetonide 20 mg and dexamethasone 4 mg was injected in the upper and lower retroseptal orbital spaces three or four times at one-month intervals. The patients were examined periodically after each injection and at least three months after the last injection.
Results: Mean pre-injection CAS was 5.2 ± 1.3 which was improved to 1.6 ± 1 after the fourth injection (P < 0.001). Upper and lower lid retraction improved in 100% and 68.2% of the affected eyes, respectively. Strabismus completely resolved in one of five affected patients and the most significant improvement was observed in supraduction. Mean improvement in exophthalmos was 1.2 ± 1.1 mm. Visual acuity did not significantly change after the injections. Eyelid ecchymosis and/or subconjunctival hemorrhage was observed in 7.1% and intraocular pressure rise occurred in 8.8% of eyes.
Conclusion: Orbital steroid injections can be used for the treatment of active thyroid ophthalmopathy when the patient is resistant to or dependent on systemic steroids or has developed complications of systemic steroids.
Von Hippel-Lindau Disease and the Eye
Authors: Karimi Saeed , Arabi Amir , Shahraki Toktam , Safi Sare
Published: February 2020

Retinal hemangioblastoma (also referred to as retinal capillary hemangioma) is a benign lesion originating from the endothelial and glial components of the neurosensory retina and optic nerve head. Historically known as a manifestation of the von Hippel- Lindau (VHL) disease, it can be seen as an isolated finding or in association with some rare ocular conditions. In addition to characteristic ophthalmoscopic features, results of numerous ancillary tests including angiography, ultrasound, optical coherence tomography, and genetic tests may support the diagnosis and differentiate it from similar conditions. Because of serious life-threatening complications of VHL disease, every ocular approach to retinal hemangioblastomas should be in relationship with additional multidisciplinary diagnostic and therapeutic efforts. In addition, any patient with actual or probable diagnosis of VHL disease should be screened for ocular involvement. Unfavorable visual loss can occur early, and ocular complications of VHL range from exudative retinopathy to tractional retinal detachment, neovascular glaucoma, and phthisis bulbi. Accordingly, various treatment methods have been tested with overall acceptable responses, including photocoagulation, cryotherapy, photodynamic therapy, plaque radiotherapy, vitrectomy, and more novel intra-vitreal injections of anti-vascular endothelial growth factors and propranolol.
Unilateral Duane Retraction Syndrome Associated with Unilateral Congenital Cataract
Authors: Farvardin Majid , Bolkheir Alireza
Published: February 2020

Purpose: To report unilateral congenital cataract in a case of ipsilateral Duane retraction syndrome.
Case Report: In this case, we present a six year old girl who was referred with ocular deviation. She had a history of congenital cataract surgery in the left eye at the age of two years. The subject had no associated systemic disease, developmental delay, or positive family history. She was finally diagnosed as having Duane retraction syndrome in the same eye.
Conclusion: Duane retraction syndrome can be associated with congenital cataract due to the matching time of gestational development of the lens to that of ocular and nonocular anomalies associated with Duane syndrome. As both of these disorders are rare, coincidence of both in the same person and the same eye by chance is a very remote possibility.
Optic Nerve Cysticercosis at the Orbital Apex
Authors: Dhahir Al-Mendalawi Mahmood
Published: February 2020

This is a Letter to Editor and does not have an abstract.
Author's Reply to Optic Nerve Cysticercosis at the Orbital Apex
Authors: Goel Neha
Published: February 2020

This is a Reply Letter and does not have an abstract.
Prevalence of Visual Impairment in School Children
Authors: Gharebaghi Reza , Heidary Fatemeh
Published: February 2020

This is a Letter to Editor and does not have an abstract.
Time to Call into Question the Fundus-based Evaluation of Diabetic Retinopathy after Intravitreal Injections
Authors: Tadayoni Ramin
Published: February 2020

This is an Editorial and does not have an abstract.
PREDICTING THE POTENTIAL BANKRUPTCY OF COAL MINING COMPANIES USING ALTMAN Z-SCORE METHOD DURING 2012-2016 PERIOD
Authors: Ernayani Rihfenti
Published: February 2020

Purpose of the study: This study aimed to determine and predict potential bankruptcy in coal mining companies listed in Indonesia Stock Exchange (IDX) period 2012-2016.

Methodology: This study to using the Altman Z-Score method, with five (5) ratios, namely Working Capital to Total Asset, Retained Earnings to Total Assets, Earning before interest and tax to total assets, Market Value of Equity to Book Value of Debt, and Sales to Total Assets. The ratio of working capital to total assets (X1) is a ratio of liquidity which measures the extent of working capital that is used to finance the total assets.

Main Findings: The result showed, by the Z-Score value in 2016 from the coal mining companies studied, four companies fall in the category of potential bankruptcy, three companies in the grey area, and four in the healthy category.

Applications of this study: Data sources in this study were coal mining companies listed on the Indonesia Stock Exchange (IDX) for the period 2012-2016.

Novelty/Originality of this study: There are 11 coal mining companies taken as sample based on purposive sampling. The result shows, by the Z-Score value in 2016 from the coal mining companies studied, four companies fall in the category of potential bankruptcy, three companies in the grey area, and four in the healthy category.
HIGHER EDUCATION INTERVENTION IN RADICALISM WITH HEBAT (HYPNOTHERAPY, E-LEARNING, COUNSELING, RELIGIOUS ACTUALIZATION, AND TECHNOLOGY)
Authors: Fathoni Rodli Achmad , Boeriswati Endry , Adhi Prasnowo M , Hidayatulloh Syarif , Nirwana Sari Renny
Published: February 2020

Purpose of the study: This research has a purpose as a form of intervention efforts against the ingress of radicalism in college.

Methodology: Research conducted using the method of HEBAT (Hypnotherapy, E-learning, Counseling, Religious Actualization, and Technology) at five universities for research.

Main Findings: with game HEBAT aid, it can be seen that the tendency of the character and personality of students leads to individualism as much as 21% and as much as 13% radical. From these results, then conducted a phase of therapy to lower the level of inclination using the application of practice Ahlusunnah Wal Jamaah.

Applications of this study: the research object is the students in the college student organization internally.

Novelty/Originality of this study: The application of practice Ahlusunnah Wal Jamaah Annahdiyah in the form of activities that reflect Tawassuth, Tawazun, I'tidal, and Tasamuh that in activities inserted hypnotherapy techniques. In the last phase of deepening given shape in the form of counseling and provision of material via e-learning.
Evaluation of serum vitamin D levels in premenopausal women with iron deficiency anemia
Authors: ATALAY Eray , BİLGEHAN Gökhan , ŞİŞMAN Pınar , ERDOĞDU Halil İbrahim
Published: February 2020

Objectives:
In recent years, many effects of
vitamin D except on bone metabolism have been discovered. Vitamin D contributes
to the correction of the anemia by acting on the erythroid precursors in the
bone marrow via Vitamin D Receptor and provides the elimination of free
radicals and prooxidant substances secondary to iron deficiency due to its
antioxidant effect in iron deficiency anemia (IDA).

Methods: A total of 97 female premenopausal
women aged 18-44 were included in the study. Fifty patients with hemoglobin
levels below 12 mg/dl and iron deficiency were classified as IDA group, and 47
subjects with hemoglobin levels of 12 mg/dl and above were classified as
control group. The demographic data and biochemical parameters of all patients
included in the study were analyzed.

Results: The vitamin D of the patient group
was found to be 7.87 ± 3.63 ng/ml and the vitamin D of the control group was
11.84 ± 6.72 ng/ml. The difference between the groups was statistically
significant. There was a positive correlation between serum vitamin D and serum
hemoglobin, hematocrit, serum MCH, serum iron level, transferrin saturation
index, ferritin.

Conclusions: In the light of the results of our study and other studies in the
literature, we think that vitamin D deficiency may be important in patients
with IDA and that vitamin D deficiency in these individuals will contribute to
the regulation of anemia due to positive effects of vitamin D on both
erythropoiesis and hepcidin in IDA are considered. However, larger studies are
needed to clarify this issue.
Histological and immunohistochemical study of nerve fibers and ganglia in the periarterial adipose tissue of the pulmonary artery bifurcation in patients with and without pulmonary hypertension
Authors: Mitrofanova L. B. , Perminova A. A. , Goncharova N. S. , Mikhailov E. N.
Published: February 2020

Background. One of the possible methods of reducing pressure in the pulmonary artery (PA) in pulmonary hypertension (PH) is radiofrequency damage of the periarterial nerve fibers. At the same time, the impact of the autonomic nervous system has not been fully determined yet. It is also known that dopamine induces LA vasorelaxation, however, the subtypes of dopamine receptors involved in this mechanism have not yet been identified.

Objective. To assess the morphology of nerve fibers and ganglia in the periarterial adipose tissue of the PA bifurcation in patients with and without PH. Design and methods. Tissue samples of the PA bifurcation zone with surrounding fatty tissue were taken from 8 patients with PH and 9 patients without PH (autopsy material): 7 women aged 59 ± 22 years and 10 men 62 ± 15 years. An immunohistochemical reaction was performed with antibodies to S100 protein, tyrosine hydroxylase (TH), M1 muscarinic receptor, D1, D2, D5 dopamine receptors. The number of nerve fibers and ganglia per area of the preparation, their diameter and depth relative to the PA intima were estimated.

Results. There were no statistically significant differences in the structure and size of nerve fibers and ganglia in patients with and without PH. In general, the average number of nerve fibers per area of the preparation (4 cm2) was 29,1 ± 15,5; ganglia — 1,1 ± 1,3; the average fiber diameter was 130,6 ± 35,1 pm, ganglia — 532,0 ± 790,7 pm; the average fiber-intima distance was 2141,4 ± 663,3 pm, the ganglion-intima — 1799,0 ± 500,5 pm. The density of fibers around the PA bifurcation was significantly higher (p = 0,04) in patients with chronic heart failure (CHF) II NYHA functional class (FC) (20 ± 10 fibers / 4 cm2) compared to patients with CHF III-IV FC (11 ± 4 fibers / 4 cm2). The expression of M1 and TH was determined on nerve fibers and ganglia, in the endothelium and smooth muscle cells of the PA, in the epithelium of the bronchi. At the same time, unlike M1, the expression of TH was not observed in all nerve cells, and its level ranged from 1 to 4 points. No D2 receptor expression was detected, D1 expression was mild, and D5 was 4 points in all cases in the endothelium and smooth muscle cells of the LA.

Conclusions. Morphometric analysis of nerve fibers and ganglia revealed no differences between patients with and without PH. There was a significant decrease in the number of nerve fibers with the progression of heart failure. TH expression on nerve fibers and ganglia was less pronounced and was not observed in all cells as compared with the M1 receptor. Expression of dopamine receptors was detected only in the endothelium and smooth muscle cells of the PA. Further morphological study involving larger sample will allow the substantiation for the validity of the interventional innervation of the PA.
Der performative Zauber der Sirenen? Adornos negative Dialektik und das deutschsprachige Gegenwartstheater
Authors: Englhart Andreas
Published: February 2020

Wieso flüchtete ADORNO, der Philosoph der Student*innenrevolte, der Fürsprecher der Avantgarde von Schönberg bis Beckett, im April 1969 vor der Performance protestieren-der Studentinnen mit nackten Brüsten? Der Beitrag erörtert Verbindungen von ADORNOS Dialektik der Aufklärung, Negativer Dialektik und Ästhetischer Theorie zur Ästhetik des heutigen performativen oder postdramatischen Theaters. Dennoch blieb für ADORNO das Theater ein Ort der Kunst, verwirklichte sich die Revolution nicht in der performativen Verweigerung von Sinn, im grausamen Realen der ‚Sirenen‘ und der Dekonstruktion, sondern in einem Werk, das das Unversöhnliche darzustellen und so zu versöhnen habe.
Julian Pölslers Verfilmung von Marlen Haushofers Roman „Die Wand“ als unabgeschlossener Wandlungsprozess
Authors: Kory Beate Petra
Published: February 2020

2012 verfilmte der österreichische Drehbuchautor und Regisseur JULIAN ROMAN PÖLSLER sein ‚Lebensbuch‘ Die Wand, MARLEN HAUSHOFERS 1963 erschienenen Roman. Da PÖLSLER sich exakt an die Romanvorlage halten wollte, entschied er sich für den Einsatz des Voice-overs, die ihm massive Kritik seitens der Filmtheoretiker einbrachte. Dem Film wurde in der Folge als ‚Hörbuch mit Bildern‘ jegliche Originalität abgesprochen. Daher setzt sich dieser Beitrag zum Ziel, durch den Vergleich des Films mit der Romanvorlage den persönlichen Beitrag des Regisseurs zur Deutung des Romans hervorzuheben, wobei auch auf die Funktion der Unterschiede des Films im Vergleich zum Roman im Filmgefüge eingegangen wird.
AGE ASPECTS OF MORPHOLOGICAL CHANGES OF GALLBLADDER SHEATHS IN ACUTE CHOLECYSTITIS
Authors: Polyansky M. B. , Nazarenko D. P. , Ishunina T. A.
Published: February 2020

In this study, the analysis of morphological changes of the gallbladder was carried in patients with acute cholecystitis of four age groups: young (25-44), middle (45-59), old (60-74) and senile (75-89) age. In patients older than 50 years the more pronounced growth of dense connective tissue (p=0,028) and a higher degree of lymphocytic infiltration (p=0,045) was observed in the adventitia as compared to women younger than 50 years. In patients of the elderly and senile age in the mucosa the number of macrophages was higher than in women of the young and middle age (p= 0,03). In the old age group, the cross-sectional area of the nuclei of the surface epithelium was significantly higher than young women (p=0,018). These changes point to chronic protracted course of gallstone disease in women of older age groups and acute inflammation in patients of the younger age.
THE MORPHOLOGY OF THE MICROCIRCULATORY BED OF THE LIVER DURING EXPERIMENTAL INHALATION OF HYDROCHLORIC ACID VAPORS
Authors: Shadlinsky V. B. , Garaev G. Sh. , Khydyrova Kh. F.
Published: February 2020

The aim of the study was to investigate changes in the hepatic vessels of small diameter under the influence of exogenous intoxication caused by respiratory way. Experiments were carried out on 16 rabbits of the chinchilla breed, which were divided equally into 4 groups. The first group included the control animals whose vascular structures were considered intact. The second group included the animal liver preparations which were studied on the 10th day of the experiments, and the III group animals were investigated on the 30th day of the experiment. The animals included into the IV group were killed on the 60th day of the experiment and preparations of the left lobe of their livers were investigated. It was found that on the 10th day of the experiments in the left lobe of the liver of the studied animals, there was an increase in the number and magnitude of the diameter of the vessels of the microcirculatory bed. On the 30th day of the experiments, on the contrary, the number of functioning hemocapillaries and their diameters are decreased. By the end of experiments of the phenomenon of a reduction of the microcirculatory bed in a liver were even more aggravated.
MORPHOLOGICAL CHANGES OF THE RETICULAR ZONE OF THE CORTEX OF ADRENAL GLANDS AND OF THE SECRETORY ACTIVITY OF ITS CORTICOSTEROCYTES IN THE PUBERTAL PERIOD IN RATS DEVELOPING AT THE INFLUENCE OF THE ENDOCRINAL DISRUPTER DICHLORODIPHENYLTRICHLOROETHANE
Authors: Tsomartova D. A. , Yaglova N. V. , Yaglov V. V. , Obernikhin S. S. , Nazimova S. V. , Sledneva Y. P.
Published: February 2020

Affection of developing organism by endocrine disruptors is an actively studied topic of scientific research in medicine, caused by a progressive increase in the number of diseases and disorders in the development of the reproductive and endocrine systems. Dichlorodiphenyltrichloroethane (DDT) is the most wide-spread endocrine disruptor. Low-dose exposure to DDT disrupts production of sex steroids by poorly known mechanisms. The research was focused on assessment of morphology of adrenal zona reticularis and fine structure of reticularis endocrine cells and changes in their secretory machinery in rats exposed to low doses of DDT during prenatal and postnatal development. The experimental group consisted of the male offspring of dams, who daily consumed solution of o, p-DDT at a concentration of 20 µg/l, from mating until the end of the suckling period in offspring, which then consumed a similar solution of DDT. Daily consumption of DDT by the offspring was 2,90±0,12 µg/kg body weight. These doses corresponds to levels of exposure of humans to DDT with food products taking to account the differences in metabolism of DDT in rats and humans. The control and experimental rats were sacrificed on the 42nd day of postnatal development (pubertal period). Light microscopy of adrenal sections found hypoplasia of zona reticularis in rats after developmental exposure to endocrine disruptor. Electron microscopy revealed prevalence of cells with low lipid content in cytoplasm, less developed endoplasmatic reticulum and Golgi complex and signs of lowered functional activity of mitochondria indicated decreased steroidogenic activity of zona reticularis. These findings explain previously found impaired production of sex steroids in DDT-exposed rats. Electron microscopy also found that disruption of steroid secretion in reticularis cells by DDT led to compensatory enlargement of cells and increase in number of mitochondria per m2 of cytoplasm indicating development of structural support for long-term enhancement of steroidogenic activity.
THE COMPARATIVE MORPHOLOGICAL ANALYSIS OF THE NEPHROTOXICITY OF DOXORUBICIN AND NANOSTRUCTURED DOXORUBICIN IN CONDITIONS OF TRANSPLANTABLE CARCINOGENESIS
Authors: Chairkin I. N. , Chairkina N. V. , Deryabina O. N. , Medvezhonkov V. Y. , Kalmin O. V.
Published: February 2020

The study was carried out on 120 mongrel white laboratory rats, to whom were transplanted the ascitiс Zaidel's hepatoma and which were divided into three equal groups. Of these, the first group of animals was a control group without treatment. In the second group, to animals doxorubicin was injected, in the third group, nanostructured doxorubicin was injected to the animals for 21 days. The aim of the study was to assess the degree of morphological changes in the tubules and glomeruli of the kidneys under the influence of nanostructured doxorubicin and doxorubicin in the condition of transplantable carcinogenesis. Given the nephrotoxicity of the chemotherapy drugs studied, the dynamics of structural changes in the tubules and glomeruli of the kidneys was studied. Conducted a comparative morphological evaluation of the changes occurring in the kidneys. The results of a morphological study of the structural components of the kidneys prove that doxorubicin and nanostructured doxorubicin have different effects on both the tubular apparatus and the glomeruli of the kidneys in the condition of transient carcinogenesis. The use of doxorubicin is accompanied by a relatively pronounced nephrotoxic effect, which is indicated by dystrophic and necrobiotic changes in the epithelium of convoluted tubules and the glomerular apparatus of the kidneys. The use of nanostructured doxorubicin is limited to moderately expressed dystrophic changes in the epithelium of the tubular apparatus of the kidneys, the glomerular apparatus remains intact at the same time. Thus, the use of the preparation of nanostructured doxorubicin for the treatment of the ascitic hepatoma of Zaidel in experimental animals has a less pronounced toxic and damaging effect on the renal parenchyma.
ABOUT THE Xth PLENUM OF THE BOARD OF THE SCIENTIFIC MEDICAL SOCIETY OF ANATOMISTS, HISTOLOGISTS AND EMBRYOLOGISTS
Authors: Klochkova S. V. , Dydykin S. S. , Khayrullin R. M. , Nikityuk D. B.
Published: February 2020

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THE INFLUENCE OF GOLD NANOPARTICLES OF DIFFERENT DIAMETER ON THE PRENATAL DEVELOPMENT OF WHITE RATS
Authors: Mikheeva N. A.
Published: February 2020

The effect of different diameter gold nanoparticles on the prenatal morphogenesis of white rats was studied. Gold nanoparticles 5, 10, 30, 50 and 150 nm in diameter covered with polyethylene glycol were administered intravenously to pregnant female white rats on the 15th gestation day at a dose of 2.0 ml per kg of animal weight (an average of 0.5-0.7 ml per animal ) in the form of a suspension (concentration of 57 pg gold per ml, an average of 28-40 pg per animal). The presence of gold nanoparticles in tissues was visualized by the method of autometallography with silver nitrate, and the total gold content in the fetuses was estimated by atomic adsorption spectroscopy. The permeability of the hemochoric barrier for particles with diameters of 5, 10, 30, and 50 nm was established. Macro- and microscopic analyzes of fetuses and newborn rats indicate the absence of morphogenetic, teratogenic and embryo-lethal effects when administered single-fold to pregnant rats at parenteral doses of 114 mcg / kg / day during late organogenesis. The obtained data testify to the prospects of using gold nanoparticles up to 150 nm in diameter for diagnostic and therapeutic purposes (thernostics) during pregnancy.
AGE-RELATED INVOLUTION OF THE SYMPATHETIC NERVOUS SYSTEM, SUDDEN CARDIAC DEATH AND FEATURES OF DIAGNOSIS OF MYOCARDIAL
Authors: Shvalev V. N. , Rogoza A. N. , Sergienko V. B. , Reutov V. P. , Malykhina T. V. , Shitov V. N. , Prosvirin A. V.
Published: February 2020

Neurological nature of major cardiac diseases is attributed to elevated social tension. The established phenomena of early age involution of the sympathetic part of the vegetative nervous system due to Cannon's law make it possible to study the mechanism of sudden cardiac death and to search for diagnostic methods for its prevention. One of such methods is time-frequency spectral analysis of the heart rate variability at the early phases of orthostatic tests. The radionuclide diagnostic method has revealed new data on correlation between blood capillaries and sympathetic nervous plexus under myocardial infarction.
Características do mercado de trabalho russo, 2008-2018
Authors: Gnevasheva Vera A , Ryazantsev Sergey V
Published: February 2020

O estudo é dedicado à revisão das tendências atuais no mercado de trabalho russo após a transição de uma economia planejada para uma economia de mercado. Mudanças significativas afetaram tanto o processo de formação da força de trabalho quanto sua distribuição e uso. Surgiram novos problemas, como o desemprego oculto e estrutural, que afetam as possibilidades de equilibrar a oferta e a demanda de trabalho. Ênfase particular é dada à formação do segmento juvenil do mercado de trabalho, necessário para um estudo detalhado, uma vez que a formação profissional da força de trabalho afeta a possibilidade de construir e mudar o capital humano do país no futuro, e determina a futura estrutura ocupacional, suas perspectivas e a possibilidade de interações com o mercado de trabalho global. As tendências identificadas nos permitem medir a influência do Estado no mercado de trabalho, a fim de aumentar sua eficiência e otimizar o uso da mão de obra. O componente social dos processos de formação, distribuição e uso do trabalho, sem dúvida, também está refletido nos prognósticos e nas medidas para aumentar a eficiência do mercado de trabalho.
The Case of Leprosy in Work Area of Talango Health Center in Sumenep Regency: Case Control Study
Authors: Rhomdani Fetty , Sulistyorini Lilis
Published: February 2020

Introduction: Leprosy was caused by Mycobacterium leprae infection which attacks the peripheral nerves and human skin. A total of 39 cases of leprosy occurred in 2018 at the Talango Health Center and became the highest prevalence in Sumenep Regency each year. Multibacillary leprosy dominates in 76.92% of cases. This study aims to analyze the influence of physical environment factors of the home namely temperature, humidity, ventilation, occupancy density, natural lighting, wall types, and floor types on the incidence of leprosy in Talango Health Center. Method: This type of research was observational analytic with a case-control research design. The respondent chosen was 25 cases and 25 controls, taken using simple random sampling. Data were collected through observation sheets which included measurements of temperature, humidity, ventilation, occupancy density, natural lighting observations, types of walls and floors. Data analysis using a chi-square test. Result and Discussion: The results of this study indicate that there was a significant correlation of ventilation variables (p = 0,03) and natural lighting (p = 0,04), whereas in the temperature (p = 1,00), humidity (p = 0,48), occupancy density (p = 1,00), wall type (p = 1,00), and floor type (p = 1,00) found no significant correlation. The physical environment of the house has not received special attention from the local community. As long as they were still comfortable living with these conditions there was no need to take any action. Conclusion: The community needs to be increased awareness by counseling and increasing knowledge of the dangers of the physical environment of the house that were not properly maintained at minimum health standards.
The Examination of Restrained Joints Created in the Process of Multi-material FFF Additive Manufacturing Technology
Authors: Kluczynski Janusz , Sniezek Lucjan , Kravcov Alexander , Grzelak Krzysztof , Svoboda Pavel , Szachogluchowicz Ireneusz , Franek Ondrej , Morozov Nikolaj , Torzewski Janusz , Kubecek Petr
Published: February 2020

The paper is focused on the examination of the internal quality of joints created in a multi-material - additive manufacturing process. The main part of the work focuses on experimental production and non-destructive testing of restrained joints of modified PLA (polylactic acid) and ABS (Acrylonitrile butadiene styrene) 3Dprinted on RepRap 3D device that works on the "open source" principle. The article presents the outcomes of non-destructive materials test in the form of the data from the Laser Amplified Ultrasonography, microscopic observations of the joints area and tensile tests of the specially designed samples. The samples with designed joints were additively manufactured of two materials: specially blended PLA (Market name – PLA Tough) and conventionally made ABS. The tests are mainly focused on the determination of the quality of material connection in the joints area. Based on the results obtained, the samples made of two materials were compared in the end to establish which produced material joint is stronger and have a lower amount of defects.
Flexible Players within the Sheaths: The Intrinsically Disordered Proteins of Myelin in Health and Disease
Authors: Raasakka Arne , Kursula Petri
Published: February 2020

Myelin ensheathes selected axonal segments within the nervous system, resulting primarily in nerve impulse acceleration, as well as mechanical and trophic support for neurons. In the central and peripheral nervous systems, various proteins that contribute to the formation and stability of myelin are present, which also harbour pathophysiological roles in myelin disease. Many myelin proteins share common attributes, including small size, high hydrophobicity, multifunctionality, longevity, and intrinsic disorder. With recent advances in protein biophysical characterization and bioinformatics, it has become evident that intrinsically disordered proteins (IDPs) are abundant in myelin, and their flexible nature enables multifunctionality. Here, we review known myelin IDPs, their conservation, molecular characteristics and functions, and their disease relevance, along with open questions and speculations. We place emphasis on classifying the molecular details of IDPs in myelin and correlate these with their various functions, including susceptibility to post-translational modifications, function in protein-protein and protein-membrane interactions, as well as their role as extended entropic chains. We discuss how myelin pathology can relate to IDPs and which molecular factors are potentially involved.
Effect of Peg-Coated Silver and Gold Nanoparticles on Spirulina platensis Biomass during Its Growth in Closed System
Authors: Cepoi Liliana , Zinicovscaia Inga , Rudi Ludmila , Chiriac Tatiana , Rotari Ion , Turchenko Vitalii , Djur Svetlana
Published: February 2020

Silver and gold nanoparticles are a promising tool for medical and industrial application, therefore, their ecotoxicity should be carefully examined. The effect of silver (12 nm) and gold (4.7) nanoparticles coated with polyethylene glycol on Spirulina platensis biomass growth and biochemical composition was investigated. The spirulina cultivation medium was supplemented with nanoparticles in concentration range 0.025-0.5 µM. Given concentrations stimulated spirulina biomass growth, while content of proteins, carbohydrates and auxiliary pigments was affected insignificantly by presence of nanoparticles in cultivation medium. The pronounced effect of gold nanoparticles at concentration 0.5 µM on the lipids content was observed. TEM images demonstrate that nanoparticles penetrate inside the cell, resulting in ultrastructural changes in cells.
Recommendations for Promoting Patient Engagement in Chronic Care: A Consensus Conference Statement
Authors: Graffigna Guendalina , Barello Serena , Riva Giuseppe , Corbo Massimo , Damiani Gianfranco , Iannone Primiano , Bosio Albino Claudio , Ricciardi Walter
Published: February 2020

Patient engagement is receiving a growing attention in the healthcare context. However, although worldwide healthcare stakeholders agree that patient engagement is a priority for quality and effective care, no shared recommendations on how to promote patient engagement are currently available. Based on these premises, a Consensus Conference (CC) was promoted to address four main issues: What is the definition of Patient Engagement? How measuring Patient Engagement? What are the most recommended methodologies and the tools to promote Patient Engagement? What is the role of new technologies in promoting of Patient Engagement? The consensus was obtained through an iterative process that began with a systematic synthesis of the available literature in each domain followed by plenary expert discussions. This CC - including the systematic analysis of internationals scientific evidences (2749 sources across the major international scientific databases) together with experiences of a multi-disciplinary consortium of investigators and key stakeholders - attempted to provide the first evidence-based Expert Consensus Statement for the promotion of Patient Engagement in chronic care. These recommendations should be envisaged as inspirational principles to promote a real eco-system of engagement and might orient health services research and interventions.
Genome-wide association study of seed coat color in sesame (Sesamum indicum L.)
Authors: Mei Hongxian , Cui Chengqi , Liu Yanyang , Liu Yan , Cui Xianghua , Du Zhenwei , Wu Ke , Jiang Xiaolin , Zheng Yongzhan , Zhang Haiyang
Published: February 2020

Background:Sesame is an important and ancient oilseed crop. Sesame seed coat color is an extremely important agronomic trait, and is related to biochemical functions involved in protein and oil metabolism, and antioxidant content. Because of its complication, the genetic basis of sesame seed coat color remains poorly understood.Results:Genome-wide association study (GWAS) using 42,781 single-nucleotide polymorphisms (SNPs) was performed with a diverse association-mapping panel comprising 366 sesame germplasm lines in 12 environments. In total, 224 significant SNPs (P< 2.34×10−7) explaining approximately 13.34% of the phenotypic variation on average were identified, and 35 significant SNPs were detected in more than 6 environments. Out of 224 significant SNPs, 22 were located in the confidence intervals of previous reported quantitative trait loci. A total of 92 candidate genes were identified in the vicinity of the 4 SNPs that were most significantly associated with sesame seed coat color.Conclusions:The results in this paper will provide new insights into the genetic basis of sesame seed coat color, and should be useful for molecular breeding in sesame.
Precise lysosome pH indicator based on self-decomposable nanoparticles
Authors: Pang Cui , Song Chaojun , Li Yize , Wang Qiaofeng , Zhu Xiaosheng , Wu Jianwei , Tian Yi , Fan Hao , Hu Jinwei , Li Chen , Wang Baolong , Liu Wenchao , Fan Li
Published: February 2020

Background Acidic pH of lysosomes are closely related to the autophagy, thus well known of the precise lysosomes pH changes will give more information on the autophagy process and status. So far, however, only pH changes in a relative broad range could be indicated, the exactly lysosomes pH detection has never arrived. Methods In our study, we established an endo/lysosome pH indicator based on self-decomposable SiO 2 nanoparticle system with specific synthesis parameters. The central concentrated MB in the central-hollow structural nanoparticles presented sensitive release as a function of pH values from pH 4.0-4.8, which is the exactly the pH range of lysosomes. The linear correlation of the OD values and the pH values has been built up, which has been used for detection of lysosomes pH in 6 different cell lines. Results By this system, we succeeded in precise detecting the pH average changes of lysosomes before and after BPSi NPs endocytosis, clarifying the mechanism of the autophagy termination after BPSi endocytosis. Conclusions The self-decomposable nanoparticles based luminal pH indicator may provide a new methodology and strategy to know better of the lysosome pH, then indicate more details on autophagy process or other important signaling about metabolism.
Proteomic analysis to identify markers of exposure to cadmium sulphide quantum dots (CdS QDs)
Authors: Gallo Valentina , Srivast Vaibhav , Bulone Vincent , Zappettini Andrea , Villani Marco , Marmiroli Nelson , Marmiroli Marta
Published: February 2020

Background The increasing use of cadmium sulphide (CdS) quantum dot (QD)-enabled products is expected to be accompanied by their release into the environment. In this study, the whole organism Saccharomyces cerevisiae was used as a model eukaryote to study protein modulations employing 2D- gel electrophoresis and gel-free iTRAQ (Isobaric Tags for Relative and Absolute Quantitation) proteomics following cell exposure to CdS QDs for 9 and 24 h. From both biotechnological and ecotoxicological perspectives, the use of S. cerevisiae as a model organism sheds light on the impact nanomaterials have on the biochemical responses of the exposed organism. Results Key proteins involved in essential biological pathways were downregulated, in particular after 24 h exposure. These include the major proteins of the glycolytic pathway, the components of mitochondrial respiratory chain complexes III, IV and V involved in the oxidative phosphorylation chain, the ATP-dependent molecular chaperone Hsc82 as well as other proteins responsible for protein folding and ubiquitination in the endoplasmic reticulum. Some of the proteins whose expression was altered have previously been described as strongly-adsorbed by CdS QD nanomaterial surfaces as hard corona, and involved in the cytotoxicity of this class of engineered nanomaterials. These data may be extrapolated to broader contexts and a wider range of organisms by allowing the identification of robust biomarkers of exposure to CdS QDs. Conclusions The work shows the power of the model organisms S. cerevisiae in biotechnology to ensure high levels of health and environmental safety. In fact, the double proteomic approach allowed to identify early markers of exposure to CdS QDs among all the proteins reprogrammed by the treatment.
Anti-inflammatory effect of the specific carbohydrate diet in children with juvenile idiopathic arthritis
Authors: Berntson Lillemor
Published: February 2020

Background Diet has an effect on the intestinal immune system, which may have consequences for inflammatory diseases. Specific carbohydrate diet (SCD) is an effective anti-inflammatory treatment for inflammatory bowel disease in children. We explored the anti-inflammatory effect of SCD in children with juvenile idiopathic arthritis (JIA). Methods Twenty-two patients with JIA (age 6.3–17.3 years), with stable, low-to-medium disease activity, were included in the study. Seven children dropped out within two weeks from the start of SCD, and fifteen patients, who completed four to five weeks of SCD, were evaluated in the final analyses. A dietician introduced parents and children to SCD with written and verbal instructions, and regular follow-ups were performed during the intervention period. Patients were studied with clinical and laboratory examinations before, during and after the intervention. In addition to conventional JIA laboratory tests, analyses were performed of short chain fatty acids in faecal samples at inclusion and after two and four weeks of SCD. Results SCD significantly decreased morning stiffness (p = 0.003) and pain (p = 0.048), and improved physical function assessed through the child health assessment questionnaire (p = 0.022). Arthritis improved in five of the seven children with arthritis at inclusion. Faecal butyrate increased significantly (p = 0.020). Conclusions SCD has significant positive effect on arthritis activity, morning stiffness, pain and physical function in children with JIA. Our results suggest that change in bacterial activity of the intestinal canal by dietary intervention may provide an effective and feasible complementary treatment for JIA.
Longitudinal assessment of the quality of life of patients after gastric bypass
Authors: MOURA DEISE SILVA DE , PATIAS LUCIANA DAPIEVE , HERNANDEZ NATHALY MARIN , ANTONIAZZI RAQUEL PIPPI , ALVAREZ GLAUCO DA COSTA , MACHADO ANA CRISTINA DE ASSUNÇÃO , MARQUES CLANDIO TIMM , MORAES CRISTINA MACHADO BRAGANÇA DE
Published: February 2020

Background Bariatric surgery is currently considered an effective way to lose weight after failure in the clinical treatment over a 2-year period. Severe obesity is associated with a wide range of serious health complications and reduced health-related quality of life and throughout its context has a significant impact on the health, longevity and quality of life of individuals. The objective of this study was to monitor the impact of weight reduction, induced by bariatric gastric bypass surgery, on the quality of life of pre and post-operative patients at 1, 2 and 6 months. Methods Longitudinal observational study conducted from December 2016 to October 2017 in southern Brazil. The convenience sample consisted of 104 obese individuals eligible to undergo bariatric gastric bypass surgery. The quality of life evaluation was performed using the SF-36 self-administered questionnaire (The Medical Outcomes Study Short Form Health Survey). Results Obese patients presented significant weight loss after surgery and in the evaluation of quality of life the mean scores of the 8 domains of the SF-36 obtained a significant improvement (p <0.001) between time 0 and 6, as well as the components of mental health (vitality, social aspects, emotional aspects and mental health) and physical health component (functional capacity, physical aspects, pain and general state of health). Conclusions Patients who underwent gastric bypass bariatric surgery had significant improvements in quality of life during the 6 postoperative months.