bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional dissection of NEAT1 using genome editing reveals substantial localization of the NEAT1_1 isoform outside paraspeckles
Authors: Li Ruohan , Harvey Alan R. , Hodgetts Stuart I. , Fox Archa H.
Published: March 2017

Large numbers of long noncoding RNAs have been discovered in recent years, but only a few have been characterized. NEAT1 (nuclear paraspeckle assembly transcript 1) is a mammalian long noncoding RNA that is important for the reproductive physiology of mice, cancer development, and the formation of subnuclear bodies termed paraspeckles. The two major isoforms of NEAT1 (3.7 kb NEAT1_1 and 23 kb NEAT1_2 in human) are generated from a common promoter and are produced through the use of alternative transcription termination sites. This gene structure has made the functional relationship between the two isoforms difficult to dissect. Here we used CRISPR-Cas9 genome editing to create several different cell lines: total NEAT1 knockout cells, cells that only express the short form NEAT1_1, and cells with twofold more NEAT1_2. Using these reagents, we obtained evidence that NEAT1_1 is not a major component of paraspeckles. In addition, our data suggest NEAT1_1 localizes in numerous nonparaspeckle foci we termed “microspeckles,” which may carry paraspeckle-independent functions. This study highlights the complexity of lncRNA and showcases how genome editing tools are useful in dissecting the structural and functional roles of overlapping transcripts.
A biochemical framework for eIF4E-dependent mRNA export and nuclear recycling of the export machinery
Authors: Volpon Laurent , Culjkovic-Kraljacic Biljana , Sohn Hye Seon , Blanchet-Cohen Alexis , Osborne Michael J. , Borden Katherine L.B.
Published: March 2017

The eukaryotic translation initiation factor eIF4E acts in the nuclear export and translation of a subset of mRNAs. Both of these functions contribute to its oncogenic potential. While the biochemical mechanisms that underlie translation are relatively well understood, the molecular basis for eIF4E's role in mRNA export remains largely unexplored. To date, over 3000 transcripts, many encoding oncoproteins, were identified as potential nuclear eIF4E export targets. These target RNAs typically contain a ∼50-nucleotide eIF4E sensitivity element (4ESE) in the 3′ UTR and a 7-methylguanosine cap on the 5′ end. While eIF4E associates with the cap, an unknown factor recognizes the 4ESE element. We previously identified cofactors that functionally interacted with eIF4E in mammalian cell nuclei including the leucine-rich pentatricopeptide repeat protein LRPPRC and the export receptor CRM1/XPO1. LRPPRC simultaneously interacts with both eIF4E bound to the 5′ mRNA cap and the 4ESE element in the 3′ UTR. In this way, LRPPRC serves as a specificity factor to recruit 4ESE-containing RNAs within the nucleus. Further, we show that CRM1 directly binds LRPPRC likely acting as the export receptor for the LRPPRC-eIF4E–4ESE RNA complex. We also found that Importin 8, the nuclear importer for cap-free eIF4E, imports RNA-free LRPPRC, potentially providing both coordinated nuclear recycling of the export machinery and an important surveillance mechanism to prevent futile export cycles. Our studies provide the first biochemical framework for the eIF4E-dependent mRNA export pathway.
Administração pública democrática
Authors: Marques Marcelo Henrique Pereira
Published: March 2017

A emergência do estado democrático de direito, o fenômeno do neoconstitucionalismo e a passagem do autoritarismo para a democracia no Brasil apontam para a necessidade de readequação da teoria do direito administrativo. É preciso criar todo um novo contexto pela democratização das bases do direito administrativo. Ainda se mantém viva a racionalidade autoritária que deu origem ao direito administrativo, montada numa estrutura patrimonial e autoritária de poder, com a administração na posição de supremacia. Isso permite à administração pública brasileira se valer de uma base teórica ultrapassada para fundamentar posturas autoritárias. Daí questionar-se qual o papel do direito administrativo na construção de uma administração pública democrática. Um modelo de administrar que sinalize uma maior inserção da democracia no direito administrativo e na administração pública é o desafio atual da disciplina. The emergence of the Democratic Rule of Law State, the phenomenon of the neoconstitutionalism and the passage from authoritarianism to democracy in Brazil point to the necessity of creating a new context of democratization of the basis of the administrative law. The authoritarian rationality that gave birth to the administrative law is still alive, with the administration taking a position of supremacy. This allows the Brazilian public administration to use a surpassed theory to justify authoritarian postures. Therefore question what the role of the Administrative Law in the construction of a democratic public administration is. A model of administration that signalizes with a wider insertion of democracy in the administrative law and in the public administration is the contemporary challenge of the discipline.
O princípio constitucional da eficiência ante o Estado (in) suficiente
Authors: Limberger Têmis , Kossmann Edson Luís
Published: March 2017

O artigo se propõe a responder ao seguinte problema: em que consiste o princípio da eficiência no contexto brasileiro e qual a dimensão do Estado para atender à exigência constitucional? Sustenta-se que é necessária uma interpretação constitucionalmente adequada do princípio da eficiência. Nesse aspecto, é de se verificar que não se trata de uma eficiência sob a ótica da iniciativa privada, onde a eficiência dialoga diretamente com (e para) a expectativa do lucro. A proposição é de uma construção ante as necessidades do Estado, compreendido em sua faceta democrática e de direito, que tem nos ditames constitucionais não somente suas limitações, mas, principalmente, as balizas norteadoras de suas ações funcionais. Assim, o Estado precisa ser eficiente e eficaz para o atendimento das demandas que o pacto constitucional lhe impôs e que se encontram substancialmente desatendidas. O método de trabalho é o hipotético-dedutivo, baseado em pesquisa bibliográfica. The article aims to answer the following question: what is the Principle of Efficiency in the Brazilian context and what is the necessary dimension of the State to meet the constitutional requirement? It is argued that a constitutionally appropriate interpretation of the Principle of Efficiency is required. In this respect, it is important to verify that this is not an efficiency from the perspective of the private sector, where efficiency converses directly with (and for) the expectation of profit. The proposition is of a construction in view of the needs of the State, understood in its democratic and legal facet, which has in the constitutional dictates not only its limitations, but mainly the guiding beacons of their functional actions. Thus, the State needs to be efficient and effective to meet the demands that the constitutional pact imposed on it and that are substantially neglected. The working method is the hypothetico-deductive, based on bibliographical research.
Gun jumping e manutenção de empregos como eficiência global da operação
Authors: De Resende Conselheiro João Paulo
Published: March 2017

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Desburocratização, descentralização e liberdade: a aterrissagem no Brasil real
Authors: Beltrão Helio
Published: March 2017

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The construction non-prefixed verb + spatial adverb in Latvian
Authors: Kalnača Andra
Published: March 2017

The status of constructions of the type non-prefixed verb + adverb with regard to expressing aspectuality (iet iekšā ‘to go in’, vērt vaļā ‘to open up’ etc.) is one of the most interesting problems in Latvian aspectology. However, too little attention has been paid in Latvian linguistics to the use of such constructions in sentences, as well as to the lexical (spatial) meanings of adverbs and their syntactic functions. This study aims to fill that gap, taking a closer look at the ways in which constructions of the type non-prefixed verb + adverb are used in sentences, as well as at the semantics of adverbs and their role in expressing verbal aspect.Whether a verb tends to bind with an adverbial modifier of place (a spatial adverb) when used in actual sentences is determined by verb semantics, resp. telicity, and does not have any direct bearing on the imperfective vs. perfective aspect of the verb or vice versa. Besides, adverbs are non-obligatory. The main conclusion of this study then is that the concept ‘construction of the type non-prefixed verb + adverb’ should be used with extreme caution with regard to verb–adverb bindings in sentences. It can, perhaps, be applied, in a very broad sense, to verbs of motion (and other telic verbs), but not to the use of all Latvian verbs in general.Kokkuvõte. Andra Kalnača: Konstruktsioon prefiksita verb + kohamäärsõna läti keeles. Üks läti keele aspektoloogia huvitavamaid küsimusi on konstruktsioonide prefiksita verb + adverb staatus aspekti väljendamisel (nt iet iekšā ‘sisse minema’, celt pāri ‘üle tõstma’). Siiski pole läti keeleteaduses pööratud piisavalt tähelepanu selle konstruktsiooni kasutamisele lauses ega adverbi leksikaalsele, s.o lokaalsele tähendusele ja süntaktilistele funktsioonidele. Tähtis on rõhutada, et lokaalse tähendusega adverbi lausesse liitmise tingib verbi semantika, s.o teelisus. Verbi imperfektiivsusel/perfektiivsusel pole sellega otsest seost, vrd skriet prom – aizskriet prom ‘minema jooksma’. Sealjuures pole adverbi kasutamine koos verbiga kohustuslik; samuti võib adverb liituda prefiksiga verbile. Sellepärast tuleb mõistet “konstruktsioon prefiksita verb + kohamäärsõna” kasutada väga ettevaatlikult, kui juttu on verbi ja adverbi liitumisest lauses. Üldjoontes võib seda mõistet kasutada liikumis verbide (ja teiste teeliste verbide) kohta, aga mitte kõigi läti keele verbide kohta, sest läti keele verbide ja adverbide kasutamine lauses ei ole grammatiseerunud ei konstruktsioonide ega eraldiseisvate vormidena.Märksõnad: verbi aspekt; teelisus; adverb; liikumisverb; prefiksita/prefiksiga verb
A learner’s grammar for Estonian: Insights from typological research
Authors: Tamm Anne , Kivik Piibi-Kai
Published: March 2017

This paper discusses the need for a modern Estonian reference grammar for learners and lays the basic groundwork for creating one. The current abundance of materials for teaching Estonian as a foreign language and recent advancements in both areal-typological linguistics and in the study of acquisition of Estonian contribute to conceptualizing a new type of grammar, and further improving the teaching and learning of Estonian. Modern language instruction orients to proficiency as the ability to use language in real life. We contend that this goal, combined with the availability of language technology and increased mobility of people increases the demands on effective teaching of language structure. Research has shown that the main difficulties for learners of Estonian concern morphology and morphosyntax. We suggest that including an areal-typological perspective on categories and concepts in describing and explaining the structure of Estonian may help learners in these areas.Kokkuvõte. Anne Tamm, Piibi-Kai Kivik: Grammatika eesti keele õppijale: võõrkeeleõpe ja tüpoloogia. Artikkel osutab ühisosale areaal-tüpoloogilise keeleteaduse ja teise keele omandamise uurimise vahel. Eesti keele morfosüntaks ja süntaks, sh evidentsiaalsuse, aspekti ja eituse väljendamine pakub huvi mõlema ala uurijatele. Keeleõppija jaoks pole siin tegu mitte ainult uue vormi, vaid ka uue grammatilise kategooria või moodustussüsteemiga (nt eitus), kus erinevuste teadvustamine, sh metalingvistiline teadlikkus võib aidata vältida vigu ja kiirendada keeleomandamise protsessi. Artikkel väidab, et kaasaegne kommunikatiivne, suhtluspädevusele suunatud keeleõpe ei väldi grammatika õpetamist, vaid teeb seda läbimõeldult ja kontekstis. Et keeletundides kasutataks võimalikult palju aega suhtlemise harjutamiseks, on vaja käepäraseid ja ammendavaid materjale iseseisvaks tööks, sh grammatikaseletusi ja pedagoogilist grammatikat. Pedagoogiline grammatika, mis põhineb lingvistilisel uurimistööl, pakub uusi võimalusi nii õpetajale kui õppijale sihtja lähtekeele kõrvutamiseks ning veaohtlike või keerulisemate keelenähtuste paremaks omandamiseks.Märksõnad: areaal-tüpoloogiline keeleteadus; eesti keel võõrkeelena; morfosüntaks; kategooriad; õppijagrammatika
ОСНОВНЫЕ НАПРАВЛЕНИЯ СТИМУЛИРОВАНИЯ ТРУДА СТАХАНОВЦЕВ КИРОВСКОГО РЕГИОНА ВО ВТОРОЙ ПОЛОВИНЕ 1930-х ГОДОВ
Authors: Chemodanov Pavel Andreevich
Published: March 2017

Цель. Целью статьи является анализ деятельности руководства предприятий и профсоюзных организаций Кировского региона по стимулированию труда в стахановском движении в указанный период.Метод или методология проведения работы. Автор анализирует фактические данные с использованием историко-сравнительного, историко-типологического и статистического методов и на этой основе формулирует свою классификацию стимулов, побуждавших рабочих рассматриваемого региона становиться стахановцами.Результаты. В конце автор приходит к выводу о преобладании материальной составляющей стимулирования стахановского труда над нематериальной, чем, по его мнению, и объясняется эффективность проводимой в этом направлении политики профсоюзных комитетов и заводских администраций.Область применения результатов. Статья может быть использована в научно-педагогической и учебной деятельности профессиональными историками, экономистами и социологами, а также студентами перечисленных специальностей.
ИЗМЕНЕНИЯ СЕМЕЙНО-ГЕНДЕРНЫХ ОТНОШЕНИЙ В КОНТЕКСТЕ СОЦИЕТАЛЬНЫХ ТРАНСФОРМАЦИЙ СОВРЕМЕННЫХ ОБЩЕСТВ
Authors: Sazonova Polina Vladimirovna
Published: March 2017

Цель исследования состоит в том, чтобы проанализировать процесс и результаты социетальных трансформаций современных обществ с точки зрения изменения семейно-гендерных отношений и определить социокультурную, экономическую и демографическую направленность этих изменений.Методология проведения исследования. Методологическим основанием статьи является междисциплинарный подход, основанный на социально-философских интенциях объединения социологической, экономической, политической, демографической отраслей знания, работающих в русле обсуждения заявленной проблематики.Результаты. В статье содержится авторская рефлексия по поводу процесса трансформации современных обществ с позиций семейно-гендерных отношений, на основании которой формулируются рекомендации по использованию результатов социетальных трансформаций в пределах властных компетенций.Область применения результатов. Результаты исследования могут быть использованы в сфере социально-политического проектирования с целью повышения эффективности комплекса социально-политических мер, направленных на поддержку семьи в современной России.
ФУНКЦИОНАЛЬНОЕ ВЗАИМОДЕЙСТВИЕ ЛЕКСИЧЕСКИХ И ГРАММАТИЧЕСКИХ ФАКТОРОВ В СИСТЕМЕ АНГЛИЙСКОГО ГЛАГОЛА
Authors: Kotova Nina Sergeevna , Kudryashov Igor Aleksandrivich
Published: March 2017

Цель. Цель проводимого исследования заключается в выявлении особенностей влияния лексической парадигматики, т.е. системы противопоставленных на взаимной основе семантических признаков определенных групп глаголов, на употребление их видо-временных форм, а также обратного воздействия – влияния видо-временных форм на лексическое значение этих групп глаголов при определенных условиях функционирования. В данном случае мы рассматриваем парадигматику в средней иерархии языка – применительно к каждому уровню отдельно.Методология. Изыскание проводится в синхронном плане на материале глагольной системы современного английского языка. Взаимодействие лексических и грамматических факторов в системе английского глагола рассматривается в функциональном аспекте. Такое рассмотрение дает возможность разграничить внутрисистемные явления и явления прагматического характера и тем самым выявить системно-структурные взаимоотношения лексических и грамматических факторов.Материалом исследования послужила обширная группа глаголов.С точки зрения взаимодействия лексического и грамматического в функционально-семантическом поле аспектуальности нас интересует значение, которое реализуется в оппозиции: непредельность – предельность (предельность соотносит действие с пределом, а непредельность обозначает действие безотносительно к его пределу). Конкретная методика, применяемая в анализе исследуемого материала, является комплексной, сочетающей в себе элементы описательно-сопоставительного и функционального методов.Результаты. Взаимосвязь и взаимозависимость лексической и грамматической парадигматики создают определенную устойчивость в употреблении лексических единиц данной парадигмы с видо-временными формами глагола. Тенденции развития и изменения языкового знака в данном случае выражаются в процессах взаимозамещения и взаимопроникновения грамматических форм, в первую очередь, под влиянием прагматических факторов. На данном материале эта тенденция прослеживается в случаях употребления глаголов 4 и 5-ой оппозиции в формах Continuous, которые употребляются вместо Indefinite. Значение грамматической формы модифицирует значения глагола, особо выделяя при этом интенсивность действия, придавая ему определенную эмоциональную окраску.Область применения результатов. Исследованный материал может найти оптимальное применение в сфере практической и теоретической лексикографии, в преподавании общей и частной (английской) лексикологии. Изыскание может оказать помощь в преподавании практического курса английского языка в средней школе и вузе при ориентации учебных программ на функциональное изучение грамматической системы языка.
Institutional Regime Shift in Intellectual Property Rights and Innovation Strategies of Firms in China
Authors: Huang Kenneth Guang-Lih , Geng Xuesong , Wang Heli
Published: March 2017

This study develops a novel conceptual framework to understand the differential impact of formal institutional regime shift in intellectual property rights on the innovation and patenting strategies of Chinese and Western firms operating in China. We argue that to the extent that Chinese firms have been deeply embedded in China’s informal institutions, they are less responsive to formal institutional changes than Western firms operating in China. Using the major China patent law reform of 2001 as an exogenous event, we find results consistent with our key arguments: With the strengthening of the previously weak (utility model) patent protection, Chinese firms are less likely to apply for such patents to safeguard their innovations than Western firms. However, this difference becomes less pronounced in regions with higher quality intellectual property rights and legal institutions that foster research and development and innovation, and when Western firms gain longer operational experience in China. This study advances our understanding of the intricate interaction between formal and informal institutions and specifically how “stickiness” may arise in their substitutive relationship because of the embeddedness of firms in informal institutional environments. It also provides important implications for policy and innovation strategies for policy makers and firms in emerging economies.
Finding the right frameworks
Authors: Foster Sam
Published: March 2017

Sam Foster, Chief Nurse at Heart of England NHS Foundation Trust, discusses the issues around job descriptions, curricula and opportunities for progression needed to ensure care delivery is fit for existing and future patients
What can feminist theory offer policy implementation challenges?
Authors: Carey Gemma , Dickinson Helen , Olney Sue
Published: March 2017

Implementation has long been a vexed issue in the mainstream public policy literature. The literature has remained more concerned with the design of policy and evidence of its impact than on the process by which it plays out. While implementation is often portrayed as a simple process of adopting best practice, experiences indicate that it is a far more complex process involving a range of actors translating policy into practice under varying conditions. Substantial changes to public service environments over the past few decades, both incremental and disruptive, have compounded this complexity. Commentators argue that it is time to look beyond current ‘best practice’ for new conceptual tools to tackle implementation challenges, particularly relating to those that take place around the many boundaries of public services (Dickinson and Sullivan, 2014a). In this paper we consider how post-structural feminist perspectives, with scope to actively challenge orthodoxies and embrace diversity and competing views, might further contemporary policy implementation research and practice.
Tilllutarniit: History, Land and Resilience in Inuit Film and Video
Authors: Igloliorte Heather
Published: March 2017

In early August 2016, Inuit artists Stephen Agluvak Puskas and Isabella-Rose Weetaluktuk co-curated an original format film festival in Montreal, produced in partnership with Concordia University, the FOFA Gallery and Terres en vues festival. For three evenings in a row, the FOFA Gallery’s outdoor courtyard, which opens onto one of the city’s busiest downtown streets, offered up Inuit ‘country’ food (traditional cuisine like raw seal meat and arctic char), music, Inuit games, and film and video. Each evening featured a series of short and feature films directed by or produced in serious collaboration with Inuit, arranged under three distinct themes; Unikausiit (history), Nuna (land) and Pimmariktuq (resilience). This interview is a conversation between Inuk art historian Heather Igloliorte and Puskas and Weetaluktuk, in which the co-curators reflect on the experience of creating the film festival.
On Indigenous Digit-al Media and Augmented Realities in Will Wilson’s eyeDazzler: Trans-customary Portal to Another Dimension
Authors: Smith Laura E.
Published: March 2017

Within a brief historical review of Native American digital and new media practices, this article closely examines Diné artist Will Wilson's eyeDazzler: Trans-customary Portal to Another Dimension (2011). This work features a rug made of 76,050 glass beads inspired by a 1970s wool Eyedazzler rug his grandmother wove. In the center, the artist inserted two black and white QR codes. When scanned the code links to a short video that effectively conflates the digital (hand) with the digital (media). Using Steven Loft's (Mohawk/Jewish) and Angela Haas's (Cherokee/German) methodological models, this paper argues that Wilson's work enhances the capability of a handwoven Navajo rug to reflect and project itself as a webbed network of knowledge. Considering how the work implicates Diné cosmologies and ecologies, eyeDazzler affirms indigenous North Americans' longstanding propensity for dynamic, multi-dimensional, and interconnected worlds. This conclusion challenges art and cultural institutions that perpetuate incongruence between modernity and Indians.
A Brief (Media) History of the Indigenous Future
Authors: Lewis Jason Edward
Published: March 2017

The concept of the ‘future imaginary’ seeks to capture the ways people imagine the futures of their societies. This article considers how Indigenous artists from North America and Oceania have used digital media to illustrate such possible futures from an Indigenous perspective. The review of their work forms the basis for a preliminary analytical framework for understanding different types of imaginings and the cultural and political work they do in expanding the possibilities of future action by Indigenous communities.
Arctic Cultural (Mis)Representation: Advocacy, Activism, and Artistic Expression on Social Media
Authors: Yunes Erin
Published: March 2017

The history of Canadian arctic culture has been predominantly informed through the work of non-Inuit anthropologists, academics, art dealers, curators, and collectors. A continuous cycle of restricted access has led to sustained discriminatory and misinformed representation of arctic life and culture in the media. Although broadband is opening the information highway, as long as restricted northern internet access remains, southern systems of control over Inuit voice and representation will be maintained. Through modern telecommunication technologies, social networking has become an important medium for Inuit self-representation, artistic expression, community advocacy, and activism in a historical narrative that has been dominated by a westernized, southern voice.
Classic Media Review
Authors: Rubio Raúl
Published: March 2017

HUNG LIKE A FLY, WRITTEN AND PERFORMED BY MARGA GÓMEZ (1997) Recorded Live at Josie’s Cabaret, San Francisco Distributed by West Lake Village, CA: Uproar Entertainment
Gay ghetto comics and the alternative gay comics of Robert Kirby
Authors: Shamsavari Sina
Published: March 2017

This article focuses on North American gay comics, especially the ‘gay ghetto’ subgenre, and on the alternative gay comics that have been created in response to the genre’s conventions. Gay comics have received little scholarly attention and this article attempts to begin redressing this balance, as well as turning attention to the contrasts between different genres within the field of gay comics. Gay ghetto comics and cartoons construct a dominant gay habitus, representing the gay community as relatively stable and unified, while the alternative gay male comics discussed critique the dominant gay habitus and construct instead an alternative gay – or ‘queer’ – habitus. The article focuses on the work on Robert Kirby, an influential cartoonist and editor of gay comics anthologies, and particularly on his story ‘Private Club’, in order to explore some of the typical themes and concerns of alternative gay ghetto comics.
Profil Hematologi Sebagai Prediktor Sepsis pada Sindrom Syok Dengue
Authors: Hediyanto Deddy , Laksanawati Ida Safitri , Indrawanti Ratni , Arguni Eggi , Rusmawaningtyas Desi
Published: March 2017

Latar belakang. Infeksi dengue di daerah endemis dapat terjadi bersamaan dengan infeksi lain. Penelitian tentang infeksi dengue pada anak sudah banyak dilakukan, tetapi masih sedikit yang meneliti tentang kejadian sepsis pada sindrom syok dengue (SSD). Profil hematologi sebagai pemeriksaan yang mudah dilakukan, diharapkan dapat digunakan sebagai prediktor sepsis pada SSD.Tujuan. Mengetahui profil hematologi sebagai prediktor sepsis pada SSD.Metode. Penelitian kohort retrospektif pada anak usia 1 bulan-18 tahun yang diambil dari data rekam medis pasien SSD dengan sepsis maupun tidak sepsis dan dirawat di RSUP Dr. Sardjito mulai 1 Januari 2011- 31 Desember 2014. Profil hematologi dan C-reactive protein (CRP) yang digunakan adalah pemeriksaan yang diambil saat pasien pertama kali masuk ke rumah sakit. Analisis statistik dikerjakan dengan analisis univariat, kemaknaan dengan Odds ratio (OR) dan interval kepercayaan 95% (IK95%).Hasil. Didapatkan 98 pasien yang memenuhi kriteria inklusi SSD, di antaranya 30 pasien SSD (30,6%) menderita sepsis. Tidak ada profil hematologi saat pasien pertama kali masuk rumah sakit menjadi prediktor sepsis pada SSD. Pemeriksaan kadar Hb (rerata 13,98±2,28 g/dL, p=0,897), hematokrit saat datang (rerata 40,5±6,6%; p=0,369), leukosit (median 5,68x 103 sel/µL; p= 0,619), trombosit (median 25,5x103 sel/µL; p=0,841). Pemeriksaan CRP dilakukan pada 40 pasien. Pasien SSD dengan sepsis 57,9% memiliki kadar CRP ≥6 mg/L signifikan lebih tinggi dibanding SSD tanpa sepsis (23,8%) dengan nilai p=0,028; OR 2,1 (IK95%: 1,1-3,9). Pemeriksaan biakan darah dilakukan pada 35 pasien, dengan biakan tumbuh pada 6 pasien DSS yang sepsis. Kesimpulan. Kadar CRP ≥6 mg/L berhubungan signifikan dengan kejadian sepsis pada SSD, sedangkan profil hematologi lain tidak.
Isolasi DNA pada Sampel Darah Tepi dan Swab Buccal pada Bayi Penderita ROP: Perbandingan Hasil Uji Konsentrasi dan Indeks Kemurnian
Authors: Siswanto Jo Edy , Berlian Tiara , Putricahya Evira , Panggalo Lidya V , Yuniani Luluk
Published: March 2017

Latar belakang. Retinopati prematuritas (ROP) adalah gangguan perkembangan dari pembuluh darah retina yang mengenai bayi prematur. Faktor genetik diduga berperan terhadap kejadian ROP. Konsentrasi dan kemurnian DNA hasil isolasi diperlukan untuk analisis pemeriksan genetik pada kasus ROP. Tujuan. Mengetahui konsentrasi dan indeks kemurnian DNA menggunakan sampel whole blood, buffy coat dan swab buccal pada kelompok bayi-bayi prematur yang masuk dalam kriteria penapisan ROP. Metode. Enam puluh dari total 182 subyek yang terdiagnosis ROP terpilih dengan systematic random sampling. Konsentrasi dihitung melalui penyerapan spektrofotometrik sinar ultraviolet. Kemurnian ditentukan dengan menghitung rasio antara OD260 dan nilai OD280. Analisis statistik dilakukan dengan uji Kruskal Wallis dan Mann Whitney. Hasil. Uji konsentrasi DNA menggunakan sampel buffy coat lebih tinggi dibandingkan whole blood dan swab buccal. Sampel whole blood mempunyai indeks kemurnian yang paling baik. Kesimpulan. Konsentrasi DNA sampel buffy coat dan whole blood cukup tinggi dengan indeks kemurnian yang baik untuk analisis genetika.
Perbedaan Kadar Vitamin D antara Hipotiroid Kongenital dan Anak Sehat
Authors: Tamara Lianda , Gurnida Dida A. , Fadil R.M.Ryadi
Published: March 2017

Latar belakang. Pertumbuhan dan perkembangan yang optimal pada anak dengan hipotiroid kongenital ditunjang oleh nutrisi yang seimbang dan adekuat. Salah satu mikronutrien yang dibutuhkan adalah vitamin D. Di Indonesia, belum ada data kadar vitamin D pada anak dengan hipotiroid kongenital.Tujuan. menentukan perbedaan kadar vitamin D antara hipotiroid kongenital dan anak sehat. Metode. Studi comparative dengan rancangan potong lintang kriteria inklusi anak berusia 1 bulan–5 tahun yang tidak mendapat suplementasi vitamin D. Periode penelitian bulan Juli hingga Desember 2015. Pemeriksaan kadar vitamin D dilakukan dengan metode ELISA. Perbedaan kadar vitamin D pada kedua kelompok dianalisis dengan Mann Whitney. Hasil. Didapatkan 70 subjek yang memenuhi kriteria inklusi terdiri atas 35 anak dengan hipotiroid kongenital dan 35 anak sehat. Kadar vitamin D rerata pada kelompok hipotiroid kongenital adalah 85,87 nmol/L dan pada kelompok anak sehat adalah 97,74 nmol/L. Kadar vitamin D pada hipotiroid kongenital berbeda bermakna dengan anak sehat (p<0,001).Kesimpulan. Kadar vitamin D pada hipotiroid kongenital lebih rendah daripada anak sehat.
Pengaruh Hipomagnesemia Terhadap Mortalitas Pasien Anak di Ruang Rawat Intensif
Authors: Gratya Resa - , Martuti Sri , Salimo Harsono
Published: March 2017

Latar belakang. Magnesium merupakan kation intraselular kedua terbanyak setelah kalium. Pasien dengan penyakit kritis yang dirawat di ruang rawat intensif memiliki risiko tinggi terjadinya hipomagnesemia. Pasien dengan hipomagnesemia memiliki mortalitas yang tinggi.Tujuan. Melakukan analisis pengaruh hipomagnesemia terhadap mortalitas pada pasien anak di ruang rawat intensif.Metode.Penelitian bersifat kohort prospektif dilakukan pada bulan Mei hingga Juli 2016 di PICU dan HCU RS Dr. Moewardi Surakarta. Subjek berjumlah 40 anak diambil secara konsekutif. Analisis statistik dilakukan dengan program SPSS 22.0 menggunakan uji chi square atau Fisher bila syarat uji chi square tidak terpenuhi, uji t independen bila sebaran data normal, atau uji Mann Whitney bila sebaran data tidak normal. Pengaruh faktor risiko dan mortalitas dianalisis dengan logistik regresi.Hasil. Di antara 40 anak terdapat 21 orang laki-laki, 26 dengan penyakit non bedah dan 18 anak gizi baik. Kejadian hipomagnesemia terdapat pada 5 dan 1 anak di antaranya meninggal. Hipomagnesemia tidak berhubungan dengan mortalitas (p=1,000; OR 1,00; IK95% 0,096-10.408). Faktor risiko yang berhubungan dengan mortalitas adalah jenis penyakit non bedah. Jenis kelamin, usia, status nutrisi dan jenis penyakit tidak berhubungan dengan mortalitas.Kesimpulan. Tidak terdapat pengaruh hipomagnesemia terhadap mortalitas. Faktor risiko yang berhubungan dengan mortalitas adalah jenis penyakit non bedah.
English language learner teacher effectiveness and the Common Core
Authors: Johnson Tammy , Wells Lorra
Published: March 2017

Common Core State Standards (CCSS) and teacher effectiveness are among the most contentious issues in education today. With an increase in English language learners (ELLs) and the rigorous requirements imposed by the CCSS, teachers are left unprepared and ELLs struggle to stay afloat. Using California as a case study, this research synthesis outlines the current problem, which includes the complexity of the CCSS, the achievement gap between ELLs and their peers, and ill-equipped teachers. In addition, present-day efforts to alleviate such difficulties like the revised World Language: English Language Development credential and multicultural training are outlined. Based on our review, we recommend targeted policy changes, which include preservice teachers’ participation in extensive fieldwork with ELLs, in-service teachers’ comprehensive professional development connected to practice, as well as a systematic evaluation process to measure ELL teacher effectiveness.
Investigating student exposure to competency-based education
Authors: Ryan Sarah , Cox Joshua D.
Published: March 2017

In recent years, most U.S. states have revised policy by providing schools at least some flexibility to move away from the Carnegie unit system, with its focus on credits and “seat time,” toward competency-based policies that link student advancement to mastery of content. Yet, there is little systematically collected information about how competency-based education is implemented, making it difficult to evaluate the impact on student outcomes. Using data from 600 students in grades 9-12 and confirmatory factor analytic techniques, we report initial reliability and validity results from the pilot administration of a survey designed to capture student exposure to elements that have been described as essential to a competency-based, student-centered model for learning and instruction. These elements include mastery-based progression, personalization, flexible assessment, and the development of specific skills and dispositions. Results suggest that the survey offers a way to reliably measure and study variation in the implementation of competency-based education. Importantly, the survey provides a way to capture implementation from the student perspective, leveraging the fact that student reports about their classroom experiences may be a particularly reliable source of information about instructional practice.
Ten Reflective Steps for Rendering Research Societally Relevant
Authors: Pohl Christian , Krütli Pius , Stauffacher Michael
Published: March 2017

Abstract While the goal of transdisciplinary research is to be relevant to society, specific instructions for accomplishing this remain implicit. We propose to improve this situation by means of a 10-step approach aimed at stimulating explicit reflections around ways to render
research more societally relevant.Today, there is an increasing need for researchers to demonstrate the practical value their research can generate for society. Over the past decade, experts in transdisciplinary research have developed numerous principles, methods, and tools for making
research more societally relevant. If researchers are unfamiliar with transdisciplinary research, they may miss opportunities to adapt these principles and tools to their research projects. We are developing a 10-step approach for joint use by transdisciplinarity experts and researchers about
how to best align their research projects with the requirements of transdisciplinarity. We have successfully applied this approach in numerous workshops, summer schools, and seminars at ETH Zurich and beyond. Ten questions guide discussions between transdisciplinarity experts and researchers
around research issues, identify and review the societal problems addressed, identify relevant actors and disciplines, and clarify the purpose and form of the interaction with them. The feedback we have obtained clearly indicates that the 10-step approach is a very useful tool: It provides
a systematic procedure for thinking through ways to better link research to societal problem solving.
Real-world Laboratories and Transformation Research: Call for Papers: GAIA Open Access Special Issue
Authors: Schäpke Niko , Stelzer Franziska , Bergmann Matthias , Lang Daniel J. , Wagner Felix , Miller Eric
Published: March 2017

A GAIA special issue will focus on reflections and empirical insights regarding real-world laboratories. In order to bring the growing research community together and to combine empirical evidence, the guest editors hereby invite colleagues to submit papers.
Co-design und co-production von Wissen für die nachhaltige Stadt: Das Reallabor Urban Office in Heidelberg
Authors: West Christina , Marquardt Editha , Gerhard Ulrike
Published: March 2017

Das Reallabor Urban Office treibt in der Wissenschaftsstadt Heidelberg nachhaltige Stadtentwicklung aktiv voran. Das Reallaborteam hat seine Arbeit mit Projekten der Internationalen Bauausstellung verknüpft, die bis 2022 in Heidelberg läuft. Bei der Entwicklung von Forschungsfragen
und Lösungswegen sind zahlreiche Praxispartner beteiligt ‐ so kann Urban Office wichtige Impulse setzen.
Philosophische Aspekte der Nachhaltigkeitsforschung und Humanökologie: Wissensintegration, Menschenbild, Ethik
Authors: Tretter Felix , Simon Karl-Heinz
Published: March 2017

Welche Anregungen kommen von der Philosophie für die aktuelle Nachhaltigkeitsforschung? Die Deutsche Gesellschaft für Humanökologie diskutiert dies bei ihrer Jahrestagung. Sie legt dabei den Schwerpunkt auf die Themen Wissensintegration, Menschenbild und Ethik und stellt
sich der Herausforderung, sie in der Zusammenschau zu erörtern.
Citizen Science in the Social Sciences: A Call for More Evidence
Authors: Heiss Raffael , Matthes Jörg
Published: March 2017

While citizen science research is already established in the natural sciences, it remains difficult to find in mainstream social sciences. Yet, social science research stands to benefit greatly from civic engagement. In this age of new technologies, citizen contributions have become
more feasible. In Austria, for example, students are engaged in a citizen science project called YAPES, in which they use their smartphones to submit comments and photos about how they get in touch with political issues. Challenges do exist for this form of research, however, from the
relation between human observation and data quality to ethical questions.
Towards a Sustainable Use of Phosphorus: A Transdisciplinary Scenario Analysis for the Administrative District of Lüneburg, Germany
Authors: Sieveking Annelie , Weber Hanna , Riewerts Bente , Böhme Melanie
Published: March 2017

Abstract Closing phosphorus (P) cycles at a local level faces many challenges. In our transdisciplinary research project, we developed and assessed scenarios of sustainable P use, focusing on stakeholders’ preferences in terms of desirability and probability. For a
future sustainability assessment, we collaboratively developed six sustainability indicators.Global food supply depends on the availability of phosphorus (P). To produce P fertilizer for agricultural use, phosphate rock is needed. Phosphate rock is, however, a finite and increasingly scarce
resource and is mined only in a few countries. By using recycled phosphates as fertilizers, it might be possible to meet the agricultural demand of P in a more sustainable manner. Based on a Formative Scenario Analysis of the administrative district of Lüneburg in Northern Germany,
this transdisciplinary study develops several scenarios aiming at closing the local P cycle. The most desirable scenario from the stakeholders’ perspective is characterized by two aspects: First, stakeholders from industry and agriculture are committed to the use of recycled phosphates,
and second, policies support P recycling efforts. This scenario is, at the same time, regarded as the least probable one because it is unlikely that statutory rules will change soon and that recycled phosphates will be accepted in agriculture or by the industry. For a future sustainability
assessment of the developed scenarios, a set of six sustainability indicators was developed.
Reading woman subject from the point view of neoliberalism in Turkey: #sendeanlat (tell your story) case study
Authors: Aka Assiye
Published: March 2017

Neoliberalism is a concept is used to explain the changes in capitalism such as saving crisis and profitability in the early 1970s. While referring to the difference between government and governance, it also fortifies a state's influence on administrative processes by minimizing it. Namely, neoliberalism problematizes the state concept and delimits it by calling individual choices. On the other hand, it includes administrative forms which support normalizations of both institutions and individuals according to market. In this study, 600 K tweets sent under #sendeanlat (tellyourstory) hashtag in which women tell their personal violence experiences will be analyzed to inspect security, violence and woman subject from the point view of neoliberalism, and their positioning to each other. As a result, the question what kind of solutions could be producible against violence mechanisms which are both reason and result of neoliberal political economy. The method of this study includes both quantitative and qualitative techniques. For qualitative analysis 1200 ranked tweet and for quantitative analysis, 600K tweets are inspected. Tweets are archived by using R Statistical Software via Twitter Rest API and quantitative techniques are applied by using the same software environment. Ranked tweets are coded with MAXQDA qualitative analysis software by using open coding approach.
PERLINDUNGAN HAK ATAS LINGKUNGAN HIDUP YANG BAIK DAN SEHAT DI ERA GLOBALISASI
Authors: Rochmani Rochmani
Published: March 2017

Environmental damage can result in the right to a good environment and healthy living in communities disrupted. Right to good living environment and healthy part of human rights. Violation of good environment and healthy is a violation of human rights. Right to environment is a human right that must be upheld and respected by the international community. Violations of the right to a good environment and healthy environment is a crime. However, that is still a lot of human rights violations occur. Right to a good and healthy environment is a fundamental human right. The rights attached to a construction that strengthen human life. In the globalization era human rights violations can be filed in an international judicial mechanisms, as a form of protection of the right to a good and healthyenvironment.Kerusakan lingkungan hidup dapat mengakibatkan hak atas lingkungan hidup yang baik dan sehat pada masyarakat terganggu.  Hak atas lingkungan hidup yang baik dan sehat bagian dari HAM. Pelanggaran terhadap lingkungan hidup yang baik dan sehat merupakan pelanggaran HAM. Hak atas  lingkungan hidup merupakan  HAM yang harus dijunjung tinggi dan dihormati oleh masyarakat internasional. Pelangaran terhadap hak atas lingkungan hidup yang baik dan sehat merupakan kejahatan lingkungan. Namun demikian yang terjadi masih banyak pelanggaran HAM. Hak atas lingkungan yang baik dan sehat merupakan hak yang fundamental manusia. Hak itu melekat sebagai yang memperkuat konstruksi kehidupan manusia. Di era globalisasi pelanggaran HAM berat bisa diajukan dalam mekanisme peradilan internasional, sebagai wujud perlindungan terhadap  Hak atas lingkungan yang baik dan sehat.
MEREKONSTRUKSI SISTEM HUKUM ADMINISTRASI MENUJU HUKUM YANG MELAYANI
Authors: Susanto Sri Nur Hari
Published: March 2017

This research aims to reconstruct the legal system, especially state administrative law so that it can function as a law that can serve the public interest. Other objectives is to study conceptually harmonize laws and regulations relating to public service. The method used is a normative legal research, which explores the use of a conceptual approach. The results showed that the reconstruction of the administrative law which is oriented toward public service, it must first pay attention to the paradigm shift of the administration of the state itself. It is thus necessary to take measures to harmonize the legislation of sectoral public services based on the principles / legal principles that are generally acceptedPenelitian ini bertujuan untuk merekonstruksi sistem hukum khususnya hokum administrasi negara sehingga dapat difungsikan sebagai hukum yang dapat melayani kepentingan publik. tujuan lainnya adalah melakukan kajian konsepsional mengharmonisasikan peraturan perundang-undangan yang berkaitan dengan pelayanan publik. Metode penelitian yang digunakan adalah penelitian hukum normative, yang membahas menggunakan pendekatan konseptual. (conceptual Approach). Hasil penelitian menunjukan bahwa rekonstruksi hukum administrasi negara yang memiliki orientasi terhadap pelayanan publik, maka harus terlebih dahulu memperhatikan perubahan paradigma terhadap administrasi negara itu sendiri. Dengan demikian perlu dilakukan langkah-langkah untuk  mengharmonisasikan peraturan perundang-undangan sektoral bidang pelayanan publik dengan berpedoman pada prinsip-prinsip/asas-asas hukum yang berlaku umum
ANALISIS PENERAPAN SANKSI PIDANA TENTANG KEJAHATAN KONSERVASI SUMBER DAYA ALAM HAYATI
Authors: Prasetyawati S.Endang
Published: March 2017

Management of natural resources and ecosystems as part of the authorized capital is essentially an integral part of sustainable development as an accomplishment of Pancasila. Indonesian nation has a rich natural diversity in it, which are of a variety of animals, one of them is an endangered species. Human behavior can currently threaten the extinction of endangered species which human ambition would like to have but do not care about habitat native population. Extinction of rare animals can be prevented by established legal protections for endangered speciesPengelolaan sumber daya alam hayati dan ekosistemnya sebagai bagian dari modal dasar tersebut pada hakikatnya merupakan bagian integral dari pembangunan nasional yang berkelanjutan sebagai pengamalan Pancasila. Bangsa Indonesia memiliki keanekaragaman kekayaan alam di dalamnya, diantaranya mempunyai berbagai macam satwa, salah satunya satwa langka. Perilaku manusia saat ini dapat mengancam kepunahan dari satwa langka yang mana ambisi manusia ingin memiliki tetapi tidak memperdulikan populasinya dihabitat asalnya. Kepunahan satwa langka ini dapat dicegah dengan ditetapkan perlindungan hukum terhadap satwa langka yang dilindungi
FUNGSI HUKUM DALAM KEHIDUPAN MASYARAKAT
Authors: R. Mawardi Didiek
Published: March 2017

The function of law as a means to achieve social justice , the reality in the life of society , there has been a shift in values  and or cultural order , ignorance of the norm of honesty , the degrdation of the feeling of shame , nor loss of trust in the legal and law enforcement , compliance with laws decreased, causing law dysfunction . The problem that arises is why the function of the law has not been fully realized and how to optimize the function of law in society. There is no other option , that the substance of the law and arbitrate should significantly oriented and argue the morality to the formation of a prosperous society ( Indonesia ) through the process of empowerment of the legal system , through a process of dialogue , as well as raise community participation .
EKSISTENSI PIDANA MINIMUM KHUSUS SEBAGAI SARANA PENANGGULANGAN TINDAK PIDANA KORUPSI
Authors: Sudirman Antonius
Published: March 2017

The essence of the  specific minimal criminal sanctions in the Anti-Corruption Act, as a means to prevent disparity in sentencing and as a deterrent effect for the corrupt. The formulation of a specific minimal criminal sanctions in the Anti-Corruption Act considered too small, so criminals are not afraid to do or repeat corruption. In the Anti-Corruption Act is not regulated on guidelines for the application of a specific minimal sentencing. Therefore, the Anti-Corruption Act needs to be reviewed with the aim to aggravate the minimal sentencing so can be a deterrent effect for the corrupt, and stipulate sentencing guidelines as a handle in the application of a minimal criminal sanctions.