bluuebunny/crossref_metadata_2025 huggingface dataset:
Students and student life at the University of Coimbra
Authors: Vaquinhas Irene , Ribeiro Maria Manuel Tavares
Published: February 2025

A Universidade de Coimbra (Portugal) cativou claramente sucessivas gerações de estudantes, que a consideravam a instituição das futuras elites e um meio de ascensão ao poder. Quem frequentou Coimbra como estudante? Quem eram esses jovens e o que os motivava? Este artigo analisa o corpo estudantil entre 1772 e 1910 sob vários ângulos, tendo em conta o contexto histórico e o perfil socioeconómico dos estudantes. Pretende-se mostrar continuidades e descontinuidades, por vezes até a rutura de um percurso académico. Os estudantes de Coimbra desse período provinham maioritariamente de um meio burguês. A Universidade pode assim ser considerada elitista. Com base em informações sobre a origem geográfica e social, as rotinas quotidianas e as componentes da vivência estudantil, o artigo pretende traçar o perfil do estudante médio, a ligação à vida universitária e urbana e a sua força social e política.
Em 1916, Aurora Teixeira de Castro, aluna da Faculdade de Direito da Universidade de Coimbra, em Portugal, ao saber que tinha chumbado num exame, interpelou alguns membros do júri e contestou a sua decisão, apoiada por dois colegas, utilizando uma linguagem agressiva. Em consequência, foi instaurado um processo na polícia académica contra os estudantes, que viria a dar origem a um movimento de solidariedade com as “vítimas” e de protesto contra a Universidade. A análise deste processo permite um estudo das representações de género no ensino superior, numa altura em que as mulheres estavam a ser admitidas nos cursos universitários. O comportamento de revolta que envolveu o caso, desencadeado por uma pessoa que fazia parte da primeira geração de mulheres a licenciar-se em Direito em Portugal e que viria a ser a primeira notária da Europa, assinala também uma rutura com o arquétipo feminino tradicional associado à passividade e reflecte as mudanças nas identidades de género e a contestação dos símbolos de poder durante a Primeira República democrática.
Pancreatitis, Polyarthritis and Panniculitis (PPP) Syndrome - A Rare Presentation
Authors: Shah Devank , Pokharna Rupesh , Maharshi Sudhir , Sharma Kamleshkumar , Maniar Prerak
Published: February 2025

Pancreatitis, panniculitis, and polyarthritis (PPP) syndrome is a rare manifestation (prevalence 2%–3%) of underlying pancreatic pathology which is characterized by fat necrosis in subcutaneous tissue and joints. The widely accepted etiological hypothesis is systemic dissemination of pancreatic lipase. It has a mortality rate approaching 25%. We present a case of pancreatitis, panniculitis, and polyarthritis syndrome in a 52-year-old man with chronic pancreatitis complicated by pancreatico-pericardial fistula.
A new representative of the group of non-steroidal anti-inflammatory drugs in the therapeutic arsenal of a Russian doctor: pelubiprofen
Authors: Karateev A. E.
Published: February 2025

Non-steroidal anti-inflammatory drugs (NSAIDs) are the main class of analgesics used in Russian medical practice to control acute and chronic pain in various conditions. NSAIDs have proven to be effective, easy to use and affordable. On the other hand, NSAIDs are potentially unsafe: the use of these drugs is clearly associated with an increased risk of class-specific complications in the gastrointestinal tract, cardiovascular system and kidneys.

None of the NSAIDs available on the modern pharmaceutical market can be considered ideal in terms of efficacy/safety ratio. This determines the feasibility of developing new drugs from this group.

A new NSAID has now found its way into the therapeutic arsenal of Russian doctors – a member of the 2-arylpropionic acid derivative family, pelubiprofen. This drug, which is structurally similar to ibuprofen, is a moderately selective inhibitor of cyclooxygenase 2 with a very favorable profile of pharmacological properties. Pelubiprofen has been extensively tested in a series of double-blind, randomized and controlled trials comparing it with aceclofenac and celecoxib. These studies have shown the efficacy and low incidence of adverse events in the treatment of non-specific back pain, osteoarthritis and rheumatoid arthritis with the new drug.
Functional MRI in assessing brain cortex activation patterns in response to olfactory stimuli
Authors: Dolgushin M. B. , Demyanov A. P. , Martynov M. Yu. , Dvoryanchikov A. V. , Katunina E. A. , Malykhina E. A. , Tairova R. T. , Pritshepina K. A. , Belousov V. V.
Published: February 2025

Objective: quantitative assessment of the activation areas of the cerebral cortex in women and men in response to olfactory stimuli using functional magnetic resonance imaging (fMRI).

Material and methods. The study included 14 non-smoking volunteers who were right-handed from birth (8 women and 6 men; mean age – 32.7±6.4 years), without anamnestic and clinical signs of diseases of the nervous system, nasopharynx and oropharynx, and without anosmia during the COVID-19 period. fMRI was performed on a Signa PET/MR 3.0 T scanner (GE Healthcare) with a 32-channel coil. Each olfactory stimulus (lavender and pine needles) was delivered alternately from a 200 ml syringe containing cotton wool soaked in essential oil through a PERFOMA-Judkins catheter. The syringe was opened for 4 seconds for delivery, after which delivery was stopped and the catheter was aspirated to remove the residual odour. Odours were presented at 40 seconds intervals and each odour was presented 4 times. Data analysis focused on the primary olfactory cortex (POC), orbitofrontal olfactory cortex (OOC), insular cortex (IC), and motor cortex (Brodmann’s areas 4 and 6).

Results. All subjects showed activation of the POC, OOC, IC and areas 4 and 6 for both odour stimuli, with a slight dominance of the right hemisphere. Lavender odour often led to a stronger activation of the olfactory and motor cortex than pine needle odour. The individual activation map of areas 4 and 6 elicited by lavender odour was characterized by greater variability than the map for pine needle odour. The intensity of activation in response to both odours was higher in women than in men.

Conclusion. The odours of lavender and pine needles activate not only the olfactory areas of the cortex but also areas 4 and 6 and are characterized by certain interhemispheric and gender differences.
Lower spastic paraplegia combined with hydromyelia
Authors: Mendelevich E. G. , Kurbanova A. A.
Published: February 2025

The article presents our own clinical observation of a rare combination of two neurological conditions – lower spastic paraplegia (Strumpell disease) and the formation of a cavity in the central canal of the spinal cord (hydromyelia). The development of slowly progressive muscle weakness and spasticity in the patient's legs was associated with the presence of a cavity in the spinal cord detected on neuroimaging, leading to a misdiagnosis of syringomyelia. Subsequent review of the MRI and clinical data allowed us to interpret the formation of a cavity in the spinal cord as hydromyelia – a "benign" dilation of the central canal of the spinal cord, in contrast to syringomyelia, with no signs of neurological manifestations and no progression according to the MRI data. The revision of the diagnosis and the clinical and genetic analysis enabled the diagnosis of hereditary lower spastic paraplegia (Strumpell disease). Possible common pathogenetic mechanisms of hydromyelia and spastic paraplegia as well as modern data on the course, clinical and MRI features of hydromyelia and its differential diagnosis from syringomyelia are discussed.
Social frailty and cognitive impairment in elderly people
Authors: Komleva Yu. K. , Salmina A. B. , Kolotyeva N. A. , Shpiliukova K. A. , Bondar N. I. , Illarioshkin S. N. , Piradov M. A.
Published: February 2025

The article examines the relationship between social fragility and cognitive impairment (CI) in elderly in the context of population ageing and the increasing proportion of age-related diseases. Social fragility is defined as a progressive loss of social resources, including support and social engagement, which is associated with an increased risk of depression, cognitive decline and dementia.

A comprehensive review of studies published between 2017, and November 2024 was conducted to examine social fragility and its association with CI. The paper provides an overview of current approaches to assessing social fragility, including the use of indices and scales. The main risk factors, including depression, physical activity and CI, and the mechanisms underlying this relationship are analyzed in detail.

Particular attention is paid to the consequences of social fragility for cognitive health and possible prevention strategies. The article discusses the role of social isolation, loneliness, reduced physical activity and diminished social interactions as key aspects that increase the risk of cognitive decline. It also points out that maintaining an active social network and participating in social life can slow the progression of CI and improve the quality of life of elderly.

Our work emphasizes the need for an interdisciplinary approach to the diagnosis and treatment of social fragility, which includes the development of social relationships, the promotion of physical activity and the participation in group activities. These measures can help to strengthen cognitive reserves, reduce the negative effects of social fragility and ensure an active, long life for the elderly population.
Sile (Pencak Silat Nias) as a Negotiation of Religion and Culture between Traditional Societies, Islam, and Christianity in Ono Niha
Authors: Waruwu Famati , Tambunan Elia , Harefa Otieli , Gulo Nestilina , Apvan Bertin Baene Ria
Published: February 2025

Pencak  Silat  is  no  longer  limited  to  martial  arts  but  goes  far  beyond  this.  Suppose  it  is  generally  understood  as  a  martial  art  commonly  called  Sile.  In  that  case,  it  needs  to  be  seen from the socio-theological praxis of the people of Moro’ö District, West Nias Regency, and the people of Tugala Oyo District, North Nias Regency, where they are Nias people in general  who  tend  to  believe  traditionally  based  on  customs,    as  well  as  Christian  church  congregations,  including  Muslims.  This  article  delves  into  Nias’  traditional  pencak  silat  in  2022-2023.  The  empirical  problem  in  Christianity  is  that  there  is  a  tendency  to  label  synchronicity  that  pencak  silat  as  a  traditional  rite  for  primitive  people,  has  always  been  associated with an attempt to display the dimension of “evil spirits” as opposed to the “good spirits”  in  the  Christian  faith  with  the  modern  eyes  of  urban  people.  Meanwhile,  Muslims  tend to be positioned as immigrants. This paper is in the social setting of North and West Nias as a research field, and it is carried out with empirical qualitative research with a socio-theological approach. Data were collected by observation, interview, and documentation. It was found that there is an increasing immersion in cultural arts expressed through pencak silat as a social space (medium) for people of different faiths and traditions. It was found that North and West Nias Sile displayed spatial negotiations between culture and religion.
Pengembangan Media Pembelajaran Berbasis Android Aplikasi RIMath untuk Mendukung Literasi Digital
Authors: Ulum Achmad Miftachul , Khumainah Nanda Dila Zahrotul , Nursirot M. Arul Sholehuddin
Published: February 2025

Education is very essential for the progress of a country. This is because education can provide enormous benefits to the younger generation. In carrying out education, learning media is needed to convey material and information by teachers to students. Media is very important in learning. So teachers must look for efficient media to apply in learning so that students are happy, comfortable and enthusiastic in learning. The approach used in this research is R&D with a 4D model. There are four stages that will be carried out in this research, namely Define, Design, Develop, and Disseminate. In processing the data, researchers used descriptive analysis techniques to draw conclusions from the data obtained. In the initial stage, researchers define the problems that exist in mathematics learning. The next stage is that researchers design learning media according to teacher needs to support digital literacy. In the third stage, the researchers carried out validation. As for the validation percentage results, the material aspect received 78.125%, including the very feasible category, the integration aspect received 91.6%, including the very feasible category, and the media aspect received 68.75%, including the appropriate category. The final stage is disseminate, researchers disseminate learning media to MTS Miftahul Ulum.
Enhancing second language motivation and facilitating vocabulary acquisition in an EFL classroom through translanguaging practices
Authors: Wang Xince , Xia Chunlai , Zhao Qiujie , Chen Liping
Published: February 2025

With the growing prominence of bilingual and multilingual education, translanguaging has garnered increasing attention. This approach not only challenges traditional English-as-a-Foreign-Language (EFL) research, which has historically focused on specific learning outcomes, but also shifts the emphasis to the dynamic processes involved in Second Language (L2) teaching and learning. By integrating multilingual and multimodal resources, translanguaging enhances students’ L2 motivation and vocabulary acquisition in the EFL classroom. This study adopts translanguaging as both a pedagogical tool and an analytical lens, offering insights into how the teacher uses translanguaging in designing the course and conducting vocabulary instruction. New characteristics of teachers’ translanguaging practices in vocabulary instruction are identified from the dynamic process of teacher-student meaning-making through translanguaging practices. Participants from focus group report the shift of L2 Motivational Self System from Ought-to L2 Self to Ideal L2 Self and L2 Learning Experience, the enhancement of L2 motivation, and cognitive, interactive, and motivational benefits from translanguaging practices. Overall, this research contributes to the growing body of literature on translanguaging, highlighting its role in creating a more inclusive and effective L2 learning environment in EFL settings. It also offers practical recommendations for educators to enhance students’ motivation, engagement, and success in vocabulary learning through the use of translanguaging.
Behavioral and histopathological insights into phenylthiazolyl-1,3,5-triazines: potential antidepressant candidates in a rat model of depression
Authors: Sati Aarti , Kyllait Pynshngainlang , Gahtori Prashant , Bhat Hans Raj , Hussain Md Sadique , Gupta Gaurav , Gahtori Archana
Published: February 2025

Objectives

To evaluate the antidepressant-like effects of Phenylthiazolyl-1,3,5-triazine derivatives through behavioral tests, molecular docking, and histopathological analysis in a rat brain model of depression.

Methods

Phenylthiazolyl-1,3,5-triazine derivatives were synthesized and administered at a dose of 30 mg/kg in albino rats. Behavioral effects were assessed using the Forced Swim Test and Tail Suspension Test. Molecular docking with MD simulations via CDocker was employed to analyze ligand-receptor interactions. Histological analysis of brain tissues was conducted to assess structural and vascular changes.

Results

Among the derivatives, PS1 and PS5 showed significant antidepressant-like activity compared to standard imipramine. Molecular docking revealed that hydrogen bonding, pi-pi interactions, and intermolecular neighbor effects stabilized the ligand-receptor complexes. Histopathological analysis of PS1-treated rats demonstrated preserved vascular integrity, reduced edema, and the absence of hydrophobic alterations.

Conclusions

Phenylthiazolyl-1,3,5-triazines, particularly PS1, exhibit promising potential as antidepressant agents. Their behavioral efficacy and protective histological effects suggest therapeutic relevance. Further studies integrating biomarkers and gene expression analyses are needed to optimize these derivatives for clinical application.
Pioneering the future: incorporating lifestyle medicine tools in osteopathic medical education
Authors: Bansal Shipra , Shubrook Jay H.
Published: February 2025

The role of lifestyle has taken a renewed importance in disease prevention and chronic disease management. Osteopathic medicine has long focused on comprehensive, holistic care for our patients, and the tenets support the role of lifestyle medicine (LM) in osteopathic clinical care. In this commentary, the authors make the argument for incorporating LM more formally into the clinical curriculum at colleges of osteopathic medicine and will draw parallels with these two programs.
Assessing the efficacy of a hybrid closed loop system in a racial-ethnic minority cohort of children and adolescents with type 1 diabetes
Authors: Granados Andrea , Orrego Castellanos Juliana , Martinez Sanchez Andrea , Giraldo Maria Jose , Carrillo-Iregui Adriana
Published: February 2025

Objectives

Despite improved outcomes in the use of a hybrid closed loop system (HCLS), significant disparities in the application of this technology exist among youth with type 1 diabetes (T1DM). The study aimed to evaluate the impact of a tubeless HCLS on glycemic outcomes in a pediatric racial-ethnic minority population.

Methods

A retrospective, single-center study included youth with T1D initiating HCLS Omnipod 5. Outcomes included HbA1c, continuous glucose monitor variables, BMI Z score, and episodes of diabetic ketoacidosis (DKA). Outcomes were compared from baseline, 3 and 6 months of Omnipod 5 start.

Results

The study included 174 participants, aged between 2 and 22 years, with a mean age of 7.9 ± 3.7 years. Hispanics constituted 87.3 % (152) of the cohort, with 53 % males and 47 % females. Insurance coverage was 56.9 % public, 42.5 % private, and 0.5 % uninsured. Baseline HbA1c level was 8.0 % ± 1.7, 7.3 % ± 1.1 at 3 months and 7.3 % ± 1.1 at 6 months (p<0.001). Glucose time in range (TIR) was 54.5 % at baseline to 61.9 % at 3 months, and 60.5 % at 6 months (p<0.001). Notably, there were no changes in BMI z-scores or DKA episodes following the initiation of the HCLS Omnipod 5.

Conclusions

The study showed that a tubeless HCLS significantly improved glycemic control in a pediatric minority cohort with T1DM, without affecting BMI Z-scores or increasing DKA episodes. Ongoing efforts to address disparities in diabetes technology access are crucial for optimizing care and alleviating the burden on individuals with T1DM across racial backgrounds.
The crystal structure of dichlorido(η
6-p-cymene)(triphenylarsine)ruthenium(II), C28H29AsCl2Ru
Authors: Morerwa Zanele , Clayton Hadley S.
Published: February 2025

C28H29AsCl2Ru, monoclinic, P21/n (no. 14), a = 15.4135(9) Å, b = 9.2514(5) Å, c = 35.444(2) Å, β = 97.000(3)°, V = 5016.5(5) Å3, Z = 8, R

gt
(F) = 0.0537, wR
ref(F
2) = 0.1127, T = 100 K.
Copyright Societies and Musicians in the Democratic Republic of Congo: Enduring Infrastructures in Times of Decolonization?
Authors: Pouillard Véronique
Published: February 2025

This article examines the role of copyright societies in shaping the work of musicians in the Democratic Republic of the Congo during decolonization. The Belgian colonial authorities had transferred the Western system of intellectual property rights and collecting societies to Congo during the colonial period. Intellectual property dues granted specific revenues to Congolese artists until the late colonial period under a legal regime that was otherwise repressive for the colonized. At the same time, Kinshasa became one of the early music capitals on the African continent. First, this article outlines the firms and institutions that comprised the emerging record industry in Congo. Second, it quantifies the total dues for intellectual property rights paid to Congolese musicians during the late colonial and early postcolonial periods. Third, it examines ruptures and continuities with the emergence of new authors’ rights societies in Congo during the postcolonial era. Such systems also allowed for geographical extensions among the diasporas of Congolese musicians, especially in France and Belgium, supplementing the infrastructures in the Democratic Republic of the Congo. Fourth, it highlights the continuities in Congolese copyright societies and the influence of a long and complex period of decolonization on music infrastructures.
Normativität in der Ökonomik
Authors: Polk Andreas
Published: February 2025

Der Artikel erörtert die normativen Grundlagen der Ökonomik. Diese Fragen werden in der Literatur nur selten erörtert, zum Beispiel in Michael Sandels Diskussion über die moralischen Grenzen von Märkten oder in Forschung, die Verdrängungseffekte des Marktes auf moralisches Verhalten untersucht. Der Beitrag diskutiert die Vor- und Nachteile normativer Zurückhaltung in den Wirtschaftswissenschaften. Am Beispiel des individuellen Verhaltens in Zeiten des Klimawandels wird deutlich, dass die Ökonomik die ethische Dimension des menschlichen Verhaltens nicht ignorieren sollte. Dies ist insbesondere dann der Fall, wenn der ordnungspolitische Rahmen falsche Anreize setzt und dies zu Marktversagen führt.
Shifting from a ‘just’ to a ‘fair’ transition in environmental discourse: a case of old wine in a new bottle?
Authors: Manzella Pietro
Published: February 2025

This paper investigates the language used in certain institutional documents discussing the ‘just’ and ‘fair’ transitions, aiming to determine whether this lexical shift is merely nominal or reflects differences in the construction of these concepts. Specifically, two non-binding documents are considered: the International Labour Organization (ILO) Guidelines (2015) and the European Union (EU) Council Recommendation (2022). Using the Appraisal Framework, particularly the Judgement subsystem, the paper explores how these texts evaluate human behaviour and the ethical dimensions related to environmental transitions, addressing the following questions: How is this shift discursively framed in these documents? What are the potential implications of this terminological change in terms of stance-taking and reader reception regarding environmental issues? The findings reveal that while both the ILO Guidelines and the EU Recommendation emphasise the urgency of transitioning to greener economies, the ILO Guidelines advocate for a participatory ‘just’ transition, whereas the EU Recommendation promotes a more top-down ‘fair’ transition. This distinction aligns with Rawls’ theory of justice, with the ‘just’ transition reflecting a more inclusive approach.
Rethinking late prehistoric Mediterranean Africa: architecture, farming and materiality at Kach Kouch, Morocco
Authors: Benattia Hamza , Bokbot Youssef , Onrubia-Pintado Jorge , Benerradi Meryem , Bougariane Bouchra , Bouhamidi Bouchra , Carballo-Pérez Jared , Echcherif-Baamrani Othman , Elqably Asmae , Ghayati Noufel , Hachami Hassan , Kbiri-Alaoui Mohamed , Lazarescu Raluca , Lombardi Lorena , Lucarini Giulio , Martínez-Sánchez Rafael M. , Mateu-Sagés Marta , Menéndez-Molist Pau , Montero-Ruiz Ignacio , Ouakrim Zayd , Pérez-Jordà Guillem , Radi Moad , Ramon-Torres Joan , Sobrevia-Corral Eric , Touri Tachfine , Broodbank Cyprian
Published: February 2025

The European shores of the Mediterranean are characterised by well-known sociocultural and economic dynamics during the Bronze and Early Iron Ages (2200–550 BC), but our understanding of the African shores is comparatively vague. Here, the authors present results from excavations at Kach Kouch, Morocco, revealing an occupation phase from 2200–2000 cal BC, followed by a stable settlement from c. 1300–600 BC characterised by wattle and daub architecture, a farming economy, distinctive cultural practices and extensive connections. Kach Kouch underscores the agency of local communities, challenging the notion of north-western Africa as terra nullius prior to Phoenician arrival.
Sidi Zin Archaeological Project: new investigations into the Acheulean and Middle Stone Age in Tunisia
Authors: Ben Arous Eslem , Aouadi Nabiha , Belhouchet Lotfi , Mekki Héla , Trabelsi Kaïs , Mabrouki Mosbah , Essid El Mabrouk , Fehri Noômène , Shao Qingfeng , Falguères Christophe , Lebreton Vincent , Roberts Patrick , Patalano Robert
Published: February 2025

The Sidi Zin Archaeological Project aims to bridge understanding of the Acheulean–Middle Stone Age transition in northern Tunisia, a relatively understudied region in the context of hominin evolution. The Sidi Zin locality will provide chronological, palaeoenvironmental, geomorphological and cultural insights into Acheulean and Middle Stone Age occupations in Tunisia.
Excavations at the Xiangranggounan site reveal changes in dwellings during the Late Bronze Age on the Qinghai-Tibet Plateau
Authors: Meng Qi , Han Fang , Lu Hongliang , Song Jixiang , Qiao Hong , Li Jiyuan , Xia Yanping , Du Zhanwei
Published: February 2025

Xiangranggounan is an intensively occupied settlement associated with the Kayue culture on the north-eastern Qinghai-Tibet Plateau. Excavations in 2022 and 2023 revealed five house types with clear stratigraphic relationships that help to expand current understanding of the evolution of prehistoric settlement patterns in harsh plateau environments.
Interdisciplinary Management of Cardiotoxicity in Outpatient Settings: A Survey on Practices, Perceptions and Potential for Improvement
Authors: Quick Silvio , Payo-Anez Lorena , Casimiro de Almeida Clara Marx , Schmitt Jochen , Ibrahim Karim , Kösters Markus , Christoph Marian , Haase Tina , Harst Lorenz
Published: February 2025

Background: Cardiotoxicity is a major concern in patients undergoing chemotherapy, requiring interdisciplinary management. However, the extent to which cardiotoxicity is managed in the outpatient setting among these specialists may vary, potentially leading to gaps in patient care. Methods: This questionnaire study assessed the current practices and perceptions of cardiologists, oncologists and gynaecologists regarding the management of cardiotoxicity in patients undergoing outpatient chemotherapy in Germany. Results: A total of 1,329 medical professionals were contacted via an online questionnaire; 132 (9.9%) were included in the survey. The participants in our survey reported treating a total of 1,905 chemotherapy patients per month (range 1–200). Of these patients, only 37% of those treated by oncologists (n=13) and 48% of those treated by gynaecologists (n=53) received cardiological care. The results showed that 37% (49/132) of the healthcare professionals surveyed said they performed cardiovascular toxicity risk assessment of chemotherapy in their clinical practice. More than half of the participants (56%, 39/70) expressed a need for simplified cardio-oncology guidelines. The majority of participants (84% [59/70] and 83% [58/70], respectively) requested tools to assist in cardiovascular toxicity risk assessment and the implementation of appropriate therapeutic measures for patients undergoing chemotherapy. Conclusion: Our study underscores potential interdisciplinary care gaps, possibly increasing the risk of undetected cardiotoxicity. Variations in cardiotoxicity management among specialities highlight the need for increased awareness and improved collaboration. Interdisciplinary clinical pathways could address these issues, as could a dedicated cardio-oncology network for primary care physicians’ support.
On invariant ideals in crossed products of torsion-free minimax nilpotent groups
Authors: Tushev A.V.
Published: February 2025

Let $R$ be a finitely generated commutative domain and let $N$ be a nilpotent minimax torsion-free group acted by a solvable group of operators $G$ of finite rank. In the presented paper we study properties of some types of $G$-invariant ideals of a crossed product $R * N$.
A policisztás ovárium szindrómával élő nők szexuális elégedettsége
Authors: Tóth Erika , Sz. Makó Hajnalka , Teleki Szidalisz Ágnes
Published: February 2025

A policisztás ovárium szindróma (PCOS) egy genetikai prediszpozícióval rendelkező, multiszisztémás endokrin betegség, amely a nők közel egynegyedét érintheti. A tünetegyüttes természetéből adódóan a PCOS-sel élő nők számos pszichés szövődménnyel szembesülhetnek, ami a betegek közel háromnegyedénél okoz pszichológiai problémákat. A közlemény célja, hogy bemutassa a PCOS-sel élő nők pszichés nehézségeit, kiemelten elemezve a kevésbé kutatott szexuális elégedettséget. Bronfenbrenner ökológiai elméletét alapul véve a szexuális elégedettségre ható tényezőket a mikro-, a mezo-, az exo-, és a makroszintek mentén tárjuk fel. A PCOS-el élő nők a szexuális elégedettség terén mind a négy szinten veszélyeztetettek lehetnek: a mikrorendszer szintjén korlátozottabban élhetik meg a szexuális vonzerejüket; a mezorendszer szintjén csökkenhet a szexuális funkcionalitásuk; az exo- és makrorendszerek szintjén pedig a PCOS kezelése és a társadalmi és vallási elvárások miatt több stresszt élhetnek meg, mint más nők. Kiemelten fontos ezért a pszichológiai szövődmények megelőzése, szűrése és terápiája. A szexuális elégedettség terén hatásosnak bizonyult a szexuális funkcionalitás javításában a metforminkezelés és a testmozgás szorgalmazása; a szexuális attraktivitás megélése terén pedig jó eredmények várhatóak a pozitív testképet támogató egyéni, valamint a párok kommunikációját ja vító párterápiáktól. További kutatás javasolt, hogy jobban feltárhassuk a PCOS-ben érintett nők szexuális elégedettségét, és az ökológiai rendszer négy szintjének szexuális elégedettségre, valamint egymásra gyakorolt hatását.
Az EU-többnyelvűség hatása a magyar szaknyelvekre: terminológiai kihívások és lehetőségek
Authors: Fischer Márta
Published: February 2025

Az Európai Uniónak sok hivatalos nyelve van, ami példátlan volumenű fordítási tevékenységgel jár. A többnyelvű uniós szövegalkotás és fordítás a hivatalos nyelvekben egy sajátos uniós szaknyelv, ún. eurolektus kialakulását is eredményezi, amely a szakmai és a tudományos nyelvhasználatra is hatással van. A tanulmány bemutatja a többnyelvűség Európai Unióban értelmezett – és a soknyelvűségtől eltérő – fogalmát, a tagállami hagyományoktól eltérő uniós szaknyelv jellemzőit, valamint mindazon speciális terminológiai feladatokat, amelyek a folyamatos fordítási kötelezettségből adódnak. Rámutat, hogy a hazai fülnek gyakran idegennek hangzó, szokatlan megnevezések mögött tudatos fordítói döntések állhatnak. Végül a tanulmány felhívja a figyelmet arra az igen fontos tényre, hogy a csatlakozást követően a fordításokat az uniós intézmények koordinálják, ezért a tagállam felelőssége, hogy az uniós többnyelvűségből adódó fordítási-terminológiai kihívásokat lehetőséggé tudja-e alakítani a magyar tudományos és szaknyelvek fejlesztésére.
Induktív vs. deduktív kutatási közelítésmód a menedzsmenttudományban: előnyök és hátrányok, lehetőségek a deduktív közelítésmód alkalmazására
Authors: Görög Mihály
Published: February 2025

A kutatásmódszertan szakirodalma általában áttekintést ad mind az induktív, mind a deduktív kutatási közelítésmódról, valamint az alkalmazható kvalitatív és kvantitatív módszerekről, miközben betekintést ad a kutatási tevékenység tudományfilozófiai alapjaiba is. Ugyanakkor ez az irodalom többnyire mellőzi a logika kutatásban betöltött szerepét, aminek eredménye nemegyszer hiányos vagy nem megfelelő érvelésként mutatkozik meg doktori disszertációkban, de még kutatáson alapuló tudományos közleményekben is. A nem megfelelő érvelés előfordulása pedig alapvetően arra vezethető vissza, hogy a kutatásmódszertan irodalma, különösen a menedzsmenttudomány területén, a logika mellőzésének következtében nemegyszer nem megfelelően értelmezi az induktív és deduktív érvelés, és így az ilyen jellegű kutatás mibenlétét. A tanulmány alapvető célja, hogy a logika tudományát segítségül hívva rávilágítson az induktív és a deduktív kutatási közelítésmód értelmezésére a menedzsmenttudomány területén. Ez szükségessé teszi a logika – amely az érvelés tudományaként meghatározó szerepet játszik az új tudás létrehozatalában Arisztotelész óta – legalapvetőbb kategóriáinak áttekintését. Ezek alapján pedig lehetőség van a menedzsmenttudomány területére vonatkoztatva újraértelmezni az alapvető kutatástípusokat, a kutatás elemzésének egységét, valamint a tudás-létrehozatal spirál modelljét.
Association of hyperuricemia with dietary patterns and alcohol consumption in the adult population. Results of the ESSE-RF epidemiological study
Authors: Karamnova N. S. , Shvabskaya O. B. , Rytova A. I. , Balanova Yu. A. , Evstifeeva S. E. , Imaeva A. E. , Kapustina A. V. , Kotova M. B. , Maksimov S. A. , Muromtseva G. A. , Shalnova S. A. , Drapkina O. M.
Published: February 2025

Aim. To study the associations of hyperuricemia (HU) with dietary patterns and alcohol consumption in the Russian population.

Material and methods. Representative samples of male and female population aged 25-64 years (17929 people, including 6593 men and 11336 women) from 13 Russian regions were examined. The response rate was ~80%. The dietary pattern was studied by the consumption rate of the main food groups. HU was diagnosed at a uric acid (UA) level >400 μmol/l for men and >360 μmol/l for women. The results are presented as odds ratio (OR) and 95% confidence interval (CI).

Results. People with HU more often consume fish (men by 28% and women by 34%) (p<0,005), less often — sweets (by 22 and 21%, respectively) (p<0,001) and cheese (by 13 and 14%, respectively) (p<0,05). In the diet of individuals with HU, excess sugar consumption is lower by 19 and 23% in men and women, respectively (p<0,001). Women with HU also have 13% lower red meat consumption, 36% lower legume consumption, 28% higher poultry consumption (p<0,001) and 25% lower low-fat dairy products (p<0,05), as well as 15% lower animal fat use in cooking (p=0,008) compared to individuals without HU. Individuals with HU do not discontinue alcohol, but its consumption is lower than in individuals without HU. In men, the amount of alcohol consumed has a linear association with the UA level of and HU risk. In general, among male alcohol consumers, the risk of HU is 1,32 [1,13-1,54] (p=0,001). In men with low alcohol consumption, the risk of HU is 1,24 [1,05-1,45] (p=0,009), with moderate and high consumption — 1,61 [1,32-1,97] (p<0,001) and 1,64 [1,27-2,12] (p<0,001), respectively.

Conclusion. The diet of individuals with HU differs significantly from the diet of individuals without HU, which is more pronounced among women. In men, the risk of HU increases linearly with the amount of alcohol consumed.
From life history theory to clinical practice: potential markers of fast life strategy
Authors: Kim O. T. , Drapkina O. M.
Published: February 2025

Currently, there is increasing evidence that early human development mediates the risk of early cardiometabolic diseases and their risk factors in adulthood. This publication considers potential markers of the so-called fast life strategy — a life cycle characterized by a high disease risk, as well as the conditions leading to the formation of such a strategy. In the future, they may allow stratifying groups at high risk of premature death from cardiovascular and metabolic diseases in routine clinical practice and conducting their early prevention.
Associations of neighborhood infrastructure with cardiovascular diseases and their risk factors: results of the ESSE-RF-3 epidemiological study
Authors: Maksimov S. A. , Kotova M. B. , Shalnova S. A. , Balanova Yu. A. , Imaeva A. E. , Kutsenko V. А. , Evstifeeva S. E. , Kapustina A. V. , Muromtseva G. A. , Karamnova N. S. , Shvabskaya O. B. , Repkina T. V. , Gonoshilova T. O. , Kudryavtsev A. V. , Belova N. I. , Shagrov L. L. , Samotrueva M. A. , Yasenyavskaya A. L. , Bashkina O. A. , Glukhovskaya S. V. , Levina I. A. , Shirshova E. A. , Dorzhieva E. B. , Urbanova E. Z. , Borovkova N. Yu. , Kurashin V. K. , Tokareva A. S. , Ragino Yu. I. , Simonova G. I. , Khudyakova A. D. , Nikulin V. N. , Aslyamov O. R. , Khokhlova G. V. , Solovyova A. V. , Rodionov A. A. , Kryachkova O. V. , Shamurova Yu. Yu. , Mikhailov E. V. , Tarabrina Yu. O. , Ataev M. G. , Radzhabov M. O. , Gasanova Z. M. , Umetov M. A. , Khakuasheva I. A. , Elgarova L. V. , Yamashkina E. I. , Balykova L. A. , Usanova A. A. , Nikitina A. M. , Savvina N. V. , Spiridonova Yu. E. , Naumova E. A. , Yudin V. S. , Keskinov A. A. , Yudin S. M. , Kontsevaya A. V. , Drapkina O. M.
Published: February 2025

Aim. To analyze the association of neighborhood infrastructure with cardiovascular diseases (CVDs) and their risk factors (RFs) in a representative all-Russian adult population sample.

Material and methods. Data from the ESSE-RF3 study conducted in 2020-2022 in 15 Russia regions were used. The total sample included 28731 men and women aged 35-74 years. The neighborhood infrastructure was assessed using the Russian version of the (Neighborhood Environmental Walkability Scale (NEWS). The following CVDs and their risk factors were assessed: hypertension, obesity, hypercholesterolemia, alcohol abuse, smoking, diabetes, coronary artery disease, myocardial infarction, stroke, and cancer. Associations of disease outcomes with neighborhood infrastructure were assessed using logistic regression with adjustment for individual sociodemographic characteristics.

Results. Population density, distance from infrastructure facilities to home, accessibility of infrastructure facilities, walkability and aesthetics of the area, as well as safety related to traffic and crime, are associated with CVDs and their risk factors. The greatest number of associations are noted with smoking, alcohol abuse, obesity, diabetes and hypertension.

Conclusion. The study results confirm the need to take into account the neighborhood infrastructure when assessing cardiovascular risk, implementing preventive strategies and urban planning decisions.
MicroRNA as biomarkers of coronary artery disease in real-world practice
Authors: Mikhailina V. I. , Meshkov A. N. , Kiseleva A. N. , Ershova A. I. , Drapkina O. M.
Published: February 2025

The literature review is devoted to circulating microRNA (small noncoding ribonucleic acid molecules) of blood plasma and serum, and potential of their use as new biomarkers of coronary artery disease (CAD) at various stages. The study results demonstrate different levels of plasma and serum microRNA expression in patients with and without CAD. In this regard, determination of microRNA expression level for minimally invasive diagnosis of CAD seems promising, as well as further prognosis of disease progression. A list of microRNAs as potential biomarkers of CAD has been compiled.
The Department of Medical Sciences of the RAS, Therapeutic Sciences Council meeting: Scientific projects marathon of Russian therapeutic departments "From innovative technologies and education to healthcare practice. Digitalization in healthcare"
Authors: Drapkina O. M. , Khovaeva Ya. B. , Vasilev L. M. , Ermachkova L. V. , Kirillov A. O. , Moiseenko N. P. , Prokopenko T. I. , Tachkin D. V. , Tikhomirov L. I. , Dumler A. A. , Uteva N. A. , Chaliy M. E. , Strigunov A. A. , Nesterova O. Yu. , Kamalov A. A. , Nevzorova V. A. , Bogdanov D. Yu. , Priseko L. G. , Gabbasova L. A. , Georginova O. A. , Armaganov A. G. , Garbuzova E. V. , Livzan M. A. , Ershova A. I.
Published: February 2025

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MYBPC3-associated cardiomyopathy: features of the course and prospects for specific therapy
Authors: Nefedova D. A. , Myasnikov R. P. , Kulikova O. V. , Drapkina O. M.
Published: February 2025

Genetic cardiomyopathies (CMP) are a group of diseases characterized by myocardial pathology not caused by hypertension, coronary artery disease, congenital and acquired defects. Development of imaging methods and molecular genetic diagnostics showed that the traditional phenotypic classification does not fully meet modern needs due to the presence of clinical, morphological and genotypic "crossing" of CMP. At the same time, in recent years, data have been obtained showing that the genetic substrate has a significantly higher prognostic value compared to the phenotype and plays a significant role in risk stratification and the choice of patient management tactics, as well as in family screening. Taken together, this has led to a shift in focus from phenotypic features to genotype as the basis for modern classifications of cardiomyopathy. One example of such a genotype-specific approach is the identification of cardiomyopathy associated with MYBPC3 gene variants as an independent entity. The aim of the article was to describe the role of MYBPC3 gene and the cardiac myosin-binding protein C encoded by it in cardiomyocyte function, to present current literature data on pathogenesis, clinical features and developing strategies for MYBPC3cardiomyopathy treatment, as well as to highlight current problems and directions for future research in this area.
Patients with atrial fibrillation after discharge from a multidisciplinary hospital: analysis of death risk and its causes based on 10-year follow-up data
Authors: Luk'yanov M. M. , Gomova T. A. , Martsevich S. Yu. , Shepel R. N. , Soplenkova A. G. , Smirnov A. A. , Valiakhmetov M. N. , Stepanova E. V. , Savishcheva A. A. , Drapkina O. M.
Published: February 2025

Aim. To evaluate the outcomes of 10-year follow-up of patients with atrial fibrillation (AF) after hospitalization in various departments of a multidisciplinary hospital and to determine the most significant prognostic factors associated with a high death risk.

Material and methods. In the outpatient registry RECVAZA-AF Tula after discharge from a multidisciplinary hospital, the outcomes for the period 2013-2024 (follow-up, 7,9±3,7 years) were assessed in 1159 patients with AF (age, 69,2±9,8 years; men, 48,0%). Information on fatal outcomes was obtained from the Regional Information System of the Tula Oblast.

Results. Over 10 years, 509 (43,9%) patients with AF died. The highest proportion of deaths was among those who had stroke and myocardial infarction (MI) — 55,1 and 52,9%, respectively, with permanent AF (51,4%), at the age of ≥80 years (66,4%). High all-cause and cardiovascular death risk was associated with the following factors: age (hazard ratio (HR)=1,04 and HR=1,06; p<0,001); prior stroke (HR=1,38; p=0,008 and HR=1,69; p=0,001); permanent AF (HR=1,36; p=0,02 and HR=1,61; p=0,009); diabetes (HR=1,67; p<0,001 and HR=1,43; p=0,015); systolic blood pressure <110 mm Hg (HR=1,96; p=0,001 and 1,82; p=0,035). Chronic obstructive pulmonary disease and low hemoglobin levels were associated with a high all-cause mortality only (HR=2,02; p=0,001 and HR=1,49; p=0,018), and prior MI was associated with a cardiovascular death risk only (HR=1,32; p=0,043). The proportion of deaths was lowest among those discharged from cardiology departments (excluding emergency cardiology) — 33,7% and internal medicine departments — 37,0%, and the highest among those discharged from neurology departments — 54,9%, emergency cardiology departments — 56,7%, and surgical departments — 47,9%.

Conclusion. Over 10 years after discharge from a multidisciplinary hospital, 43,9% of patients with AF died. The mortality rate was highest in AF with prior stroke and MI, with permanent AF, and at an age of ≥80 years. Prognostically unfavorable factors also included diabetes, chronic obstructive pulmonary disease, low hemoglobin levels, and systolic blood pressure <110 mm Hg. The lowest mortality rate was among patients discharged from cardiology (excluding emergency cardiology) and internal medicine departments, and the highest one was among those discharged from emergency cardiology, neurology, and surgery departments.
Myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable coronary artery disease
Authors: Yarmedova S. F. , Yavelov I. S. , Drapkina O. M.
Published: February 2025

Aim. To determine the potential of diagnosing myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable coronary artery disease (CAD) before an in-depth examination.

Material and methods. This cross-sectional single-center study included stable patients with an established diagnosis of CAD and complaints of paroxysmal dyspnea, who were undergoing inpatient treatment in the cardiology department (n=101). All study participants underwent treadmill stress echocardiography to detect transient myocardial ischemia. Complaints, anamnesis data, results of physical examination, laboratory tests, electrocardiography (ECG) and transthoracic cardiac ultrasound examination, including tissue Doppler were analyzed.

Results. Myocardial ischemia according to stress echocardiography was detected in 36 (35,6%) patients. According to multivariate analysis, independent signs indicating myocardial ischemia as a cause of dyspnea were the duration of dyspnea attack (odds ratio (OR) 1,43, 95% confidence interval (CI): 1,06-1,92; p=0,02), typical angina (OR 5,57, 95% CI: 1,17-26,63; p=0,031), pathological Q wave (OR 6,66, 95% CI: 2,03-21,85; p=0,002), right atrium volume (OR 0,96, 95% CI: 0,92-1,00; p=0,045) and lateral e` (OR 1,26, 95% CI: 1,01-1,57; p=0,038). When combining these variables into a single regression equation, the area under the characteristic curve (ROC curve) was 0,83, 95% CI: 0,750,91; sensitivity, specificity, positive and negative predictive value for the optimal cutoff point were 88,9, 72,6, 57,1 and 91,1%, respectively. In turn, for the point scale created using these variables, the area under the ROC curve was 0,79 with 95% CI: 0,70-0,88; sensitivity, specificity, positive and negative predictive value were 83,3 and 64,6, 56,6 and 87,5%, respectively. There was no significant difference in the areas under the ROC curve for regression equation and point scale (p=0,355).

Conclusion. The presence of myocardial ischemia as a cause of paroxysmal dyspnea in patients with stable CAD can be predicted based on the data available in real-world practice, including the characteristics of clinical manifestations, resting ECG, and transthoracic cardiac ultrasound.