bluuebunny/crossref_metadata_2025 huggingface dataset:
ELABORATION OF A METHOD OF LYSOZYME PURIFICATION FROM HUMAN SALIVA
Authors: Krenev I.A. , Berlov M.N.
Published: February 2025

Introduction. Growing antibiotic resistance dictates the need for search for alternative antimicrobial drugs. Antimicrobial polypeptides, including lyso-zyme, are among prospective prototypes. Existing methods of human lysozyme purification are less elaborated in comparison with methods of lyso-zyme purification from other species sources. The aim of the study. Development of a simple and rapid method of lysozyme purification from human saliva, which can be performed in laborato-ries equipped for research of peptides and low-molecular proteins. Material and methods. Human saliva was treated with NaCl, centrifuged, filtered through filter with pores diameter 0.45 μm, used for two-steps sol-id-phase extraction on C18 cartridges (elution with 20% and 60% acetonitrile), reversed-phase high-performance liquid chromatography on C18 column in acetonitrile gradient and re-chromatography. Homogeneity and molecular weight were confirmed by SDS-PAGE electrophoresis. Enzyme activity was confirmed in turbidimetric analysis in the presence of Micrococcus lysodeikticus. The presence of antimicrobial activity was confirmed by electrophore-sis under acidic conditions with subsequent gel overlay against Listeria monocytogenes. Results. Saliva treatment with 62.5—1000 mM NaCl did not affect total protein content in the supernatants after centrifugation. Treated with 0.5 M NaCl and filtered saliva was used for solid-phase extraction. After the separation of components eluted with 20% acetonitrile, components eluted with 60% acetonitrile were used for RP-HPLC. As the result, a major peak was obtained and the fractions used for further purification and analysis. The sample contained a protein with the molecular weight of lysozyme. The protein possessed muramidase activity towards Micrococcus lysodeikticus cell walls and antimicrobial activity towards L. monocytogenes. Conclusions. In the present study, a simple method of lysozyme purification from human saliva was elaborated (about 5 μg of lysozyme from 1 mL of saliva). The protocol preserves essential biological properties of lysozyme.
Alcoholic beverages and their effect on the body
Authors: Volga N.B. , Potapova I.V. , Seliverstov P.V. , Kutsenko V.P.
Published: February 2025

Nowadays, the problem of alcohol consumption does not lose its relevance. It is associated with many socio-economic, demographic and health problems. Therefore, it is important to continue research on the effect of alcoholic beverages on organ systems and the body as a whole, ways to prevent alcohol poisoning, study the combination of alcohol with other products, diagnosis and treatment of alcohol poisoning.
Psychological harassment (mobbing) in labor collectives
Authors: Babanov S.A. , Lysova M.V. , Ostryakova N.A. , Babanov A.S.
Published: February 2025

At present, in the conditions of transformation of the socio-economic paradigm of the Russian society and economy, continuous reforms in society and organizations of various forms of ownership, changes in the forms of traditional organization of society, decreasing demand and social recognition of a number of classical professions, growing unemployment (and in consequence of this fear of losing a job) there is an increase in the prevalence of such social and psychological phenomenon as mobbing [1–3]. Mobbing (mobbing ‒ from the English verb to mob ‒ to rude, to attack in a crowd, pack, to bully) is considered as a form of psychological violence, as a collective psychological terror, bullying against any of the workers on the part of his colleagues, subordinates or superiors, carried out in order to force the employee to leave the place of work or to weaken the degree of his social or professional influence in the team is currently becoming more widespread in production, scientific and educational teams, corporate offices
Using VR-technologies in training nursing staff
Authors: Markelova Yu.V. , Ostrovskaya I.V. , Sukhotina N.V. , Tichina I.A.
Published: February 2025

The relevance of the study of the use of VR-technologies in the training of nursing staff is due to the integration of virtual reality technologies into training programs for nursing staff, including nurses and midwives. It is found that the introduction of these technologies has the potential to significantly improve their professional performance, which is critical in the context of the demands of modern healthcare. The authors emphasize that VR-enabled learning not only contributes to the develop-ment of highly skilled nursing professionals, but also increases the digital literacy and practical skills of learners in the clinical environment. Despite current limitations such as lack of special-ized applications and high hardware costs, current trends toward lower technology costs and the development of open-source software are contributing to the increasing availability of VR solutions. Nevertheless, successful implementation of VR technologies requires a reliable techno-logical infrastructure and appropriate training of teaching staff. Successful integration of vir-tual reality technologies into the healthcare system requires government support and investment, as well as testing to evaluate the effectiveness and safety of VR technologies in different medical scenarios.
Cancer markers in nurse practice
Authors: Skvortsov V.V. , Ustinova M.N. , Erofeev D.S. , Ukhorenko I.S. , Karavayeva E.S.
Published: February 2025

Cancer markers are biological molecules that can be detected in the human body and serve as indicators of the presence of malignant tumors. Their use in clinical practice has become an important aspect of cancer diagnosis, monitoring and prediction. Since their discovery, cancer markers have attracted the attention of researchers and doctors due to their ability to provide valuable information about the patient’s condition, identify the disease at an early stage and evaluate the effectiveness of the treatment.
Peculiarities of cancer precautionary examination of patients at an outpatient surgeon’s appointment
Authors: Matveev K.A. , Penyaz E.V. , Morozov A.M.
Published: February 2025

Oncology, as one of the most urgent and complex areas of medicine, requires special attention from medical specialists, especially in the context of outpatient appointments. Every year the number of oncologic diseases continues to grow. In the context of outpatient practice, surgeons face unique challenges related to the need to quickly and accurately assess patients’ condition, as well as to develop personalized approaches to their treatment. Modern oncology requires physicians to not only have a deep knowledge of pathology, but also a high degree of empathy to support patients through difficult times. Outpatient practice is becoming an important platform for early detection of diseases, which directly affects the effectiveness of treatment.
The Effect of Underwater LED Toward Catches of Gillnets in Central Tapanuli
Authors: Fuah Ricky Winrison , Rahayu Rosi , Afranisa Zahra , Fazri Kurniawan
Published: February 2025

Most of the Central Tapanuli Regency area is on the coast, which is part of the Indian Ocean waters and has great potential in the fishing industry, especially marine fisheries. One of the fishing gears widely used by fishermen in Central Tapanuli is the gill net.  Although the amount of marine fisheries resources in Central Tapanuli is quite abundant, the catch of gillnet fishermen often fluctuates, so fishing aids are needed to increase catches, one of the efforts made is using LACUBA. This research was conducted from February to April 2024 in Sibolga Bay, Central Tapanuli. This study used a completely randomised design (CRD), with the first 30 metres of gill net treatment with LACUBA and the remaining 30 metres without LACUBA treatment with a total net length of 60 metres. The results showed that the catch of gill nets using LACUBA influenced the catch, the total catch was 16,845 grams, without LACUBA 8,290 grams for 14 times. Gill nets with LACUBA can increase catches compared to without LACUBA, due to the addition of attractants to the net, so that fish including positive phototaxis will be caught in the net, besides that fish that are looking for prey are also caught because they want to prey on their food in the gill net area.
Optimization of Local Feed Ingredient Composition to Achieve 30% Protein Levels in Cultivated Fish Feed Production
Authors: Zebua Ratna Dewi , Laoli Destriman , Telaumbanua Betzy Victor , Dawolo Januari , Zebua Okniel
Published: February 2025

Aquaculture plays a vital role in meeting the global demand for animal protein, yet the dependency on expensive imported feed ingredients remains a significant challenge. Optimizing the use of local feed ingredients is a strategic approach to enhance sustainability and cost-efficiency in fish farming. This research aims to optimize the composition of local feed ingredients to achieve 30% protein content in farmed fish feed. The formulation involves rice bran, corn bran, fish meal, and tofu dregs, selected based on local availability and protein content. The methodology includes analysis of the protein content of raw materials, formulation testing, and physical evaluation of feed. The results show that the pellets produced have nutritional quality that meets the target, good physical stability, and cost efficiency of up to 40% compared to commercial feed. This research makes a significant contribution in supporting the sustainability of the fish farming industry and reducing dependence on imported raw materials.
Pengembangan Media Video Tutorial Pembuatan Pola Bolero Berbasis Artificial Intelligence Pada Mata Pelajaran Costume Made Kelas XI SMKN 1 Ampek Angkek
Authors: Rahmawati Lusi , Nelmira Weni
Published: February 2025

Pemanfaatan teknologi seperti Artificial Intelligence dapat mendukung pembelajaran. Penelitian ini dilatarbelakangi oleh permasalahan yang terdapat dalam pembelajaran Costum Made pada pembuatan pola bolero, dimana siswa mengalami kesulitan dalam mengikuti pembelajaran terutama pada saat praktik. Hal ini dikarenakan sumber belajar atau bahan ajar terkait dengan mata pelajaran pembuatan pola bolero masih sangat terbatas. Penelitian ini bertujuan menghasilkan media pembelajaran berupa video Tutorial Berbasis Artificial Intelligence yang valid serta dapat dijadikan sebagai sumber belajar bagi siswa dalam pembelajaran Costume Made. Penelitian ini merupakan penelitian dan pengembangan yang dikenal dengan istilah Research and Development (R&D) dengan menggunakan model 4D. Model ini memiliki 4 tahap yaitu: tahap pendefinisian (define), tahap perancangan (design), tahap pengembangan (develop), dan tahap penyebaran (disseminate). Namun untuk tahap penyebaran(disseminate)tidak dapat dilakukan karena keterbatasan peneliti. Teknik pengumpulan data yang dipakai pada penelitian ini adalah observasi, wawancara dan angket. Video Tutorial ini di uji validitasnya oleh 3 orang validator 1 orang ahli media dan 2 orang ahli materi. Instrumen penelitian menggunakan lembar validasi dan lembar praktikalitas. Jenis dan sumber data menggunakan data primer. Analisa data yang digunakan adalah data deskriptif, yaitu mendeskripsikan tingkat validitas dan praktikalitas media pembelajaran video tutorial pembuatan pola bolero berbasis AI. Berdasarkan hasil uji validitas terhadap video tutorial Pembuata pola bolero diperoleh skor 88% dengan kategori sangat valid. Sedangkan hasil praktikalitas dengan guru Pembina mata pelajaran costum made didapat skor 89,6% kategori sangat praktis, praktikalitas siswa kelompok kecil didapat skor 88% kategori sangat praktis, praktikalitas siswa kelompok besar didapat skor 90% kategori sangat praktis. Dapat disimpulkan bahwa video tutorial ini dikatakan sudah layak dan dapat di uji cobakan sebagai sumber belajar pada mata pelajaran Costum Made untuk siswa SMK N 1 Ampek Angkek.
Strategies to Mitigate EFL Test Anxiety
Authors: Abd Elwahab Abd Elmajid Waleed
Published: February 2025

Test anxiety is a significant issue for many English Language students, negatively impacting their language acquisition, academic performance, and psychological well-being. This study explores the causes of test anxiety among EFL learners and investigates effective strategies to mitigate this challenge. A mixed-methods approach was employed, combining a systematic review of the literature with an original empirical study. The literature review examined current research on the factors contributing to test anxiety and the cognitive, emotional, and behavioral consequences it can have on EFL students. The empirical component involved surveying 125 male and female EFL students at Taibah University using the Foreign Language Classroom Anxiety Scale (FLCAS) to assess their levels of test anxiety. Semi-structured interviews were also conducted with a subset of 25 students to gain deeper insights into their experiences and perspectives. The statistical analysis of the survey data revealed that EFL learners commonly struggle with physiological symptoms of anxiety, persistent worries about exam performance, and concerns over teacher feedback and perceptions. The qualitative findings further highlighted the detrimental impact of test anxiety on cognitive functioning, including impaired attention, memory, and information processing. Based on the combined findings, the study provides a set of practical recommendations for EFL educators and institutions to address test anxiety. These include fostering supportive classroom environments, implementing relaxation and cognitive-behavioral techniques, leveraging technology and gamification, promoting social support, and tailoring interventions to individual and cultural needs. Integrating test anxiety mitigation into curriculum and teacher training is also emphasized as a means of ensuring sustainable and scalable solutions.
Daily life waste materials: Transforming kitchen leftovers into sustainable organic fertilizers for enhanced plant growth
Authors: Md. Nahid Mahmud  , Ahmed Ali Omar
Published: February 2025

With the increasing awareness of environmental friendliness in agriculture, there is a growing concern about the harmful effects of chemical fertilizers. As a result, alternative methods are being sought that enhance plant growth and improve soil health without harming the environment. This paper discusses waste materials used in daily life, such as banana peels, tea leaves, egg shells, coffee grounds, and other vegetable or fruit residues, which can be easily converted into organic fertilizers. The paper discusses the nutritional value of these materials, such as potassium, nitrogen, phosphorus, and calcium, which help in healthy plant growth and root strength. It explains how these materials improve soil microbial activity and help in providing the right amount of nutrients required by plants. In addition, the method of converting waste materials into compost or directly applying them to the soil is also explained in detail. This method not only reduces waste, but also acts as an environmentally friendly and effective method in agriculture, which can prove to be a sustainable and cost-effective alternative for farming. Through this method, it is possible to maintain environmental balance along with agriculture and can be profitable for farmers, which will usher in a new era in agriculture.
Developing intelligent automation workflows in Microsoft power automate by embedding deep learning algorithms for real-time process adaptation
Authors: Rama Krishna Debbadi  , Obed Boateng
Published: February 2025

The advent of intelligent automation has revolutionized business processes by integrating artificial intelligence (AI) with robotic process automation (RPA) to enable adaptive, efficient, and data-driven decision-making. Microsoft Power Automate, a widely used low-code automation platform, offers a powerful environment for developing intelligent workflows. However, traditional automation lacks dynamic decision-making capabilities, which can be significantly enhanced by embedding deep learning algorithms. This integration enables real-time process adaptation, allowing workflows to learn from historical data, predict outcomes, and make proactive adjustments without human intervention. This study explores the impact of embedding deep learning models within Power Automate workflows to enhance real-time process adaptability. By leveraging Azure Machine Learning and AI Builder, businesses can deploy deep neural networks for tasks such as anomaly detection, demand forecasting, sentiment analysis, and intelligent document processing. The research presents real-world applications across industries, including predictive maintenance in manufacturing, customer sentiment-driven automation in retail, and fraud detection in financial services. Challenges such as model deployment complexities, latency in real-time inference, and the need for seamless integration between AI services and Power Automate are also analyzed. Strategies for overcoming these challenges, such as optimizing model performance, leveraging cloud-based AI services, and ensuring scalable automation architectures, are proposed. The findings suggest that embedding deep learning models into Microsoft Power Automate can drive significant improvements in process efficiency, decision accuracy, and operational resilience, ultimately enabling businesses to achieve higher levels of automation intelligence and competitiveness.
Advances in neurology: The impact of artificial intelligence on the diagnosis and treatment of neurological diseases
Authors: Marjorie Bindá Leite  , Jeniffer Aparecida de Morais Rodrigues  , Carolina Fátima Gioia Nava  , José Wilson Lima Furtado Junior  , Wildes Aparecido da Silva Araújo  , Danielly Crispim Torres  , Marinaldo Soares Leite
Published: February 2025

Although AI has immense potential to improve the diagnosis and treatment of neurological diseases, continued progress is needed in system transparency, clinical validation, and regulation to ensure that these tools are safely and effectively adopted in medical practice. Therefore, the objective is to explore the potential of Artificial Intelligence in the early and accurate diagnosis of neurological diseases, highlighting its benefits, technical and ethical challenges, and the need for advancements in transparency, clinical validation, and regulation for its safe and effective adoption in medical practice. The methodology of this study is based on a narrative review of the literature, aimed at analyzing the impact of Artificial Intelligence on the diagnosis of neurological diseases. Despite advances, challenges remain, including the need for high-quality data and population diversity, as well as issues related to model interpretability and large-scale clinical validation. However, with the continuous improvement of AI technologies and their integration with clinical decision support systems, the perspective is that neurology will increasingly benefit from these innovations, improving the quality of patient care. The combination of AI with advances in neuroimaging, genetics, and digital monitoring has the potential to transform neurological care, enabling faster diagnoses, more effective treatments, and better quality of life for patients. Thus, Artificial Intelligence not only enhances the understanding of neurological diseases but also drives precision medicine, establishing itself as one of the pillars of the future of neurology.
An AI-driven framework for modernizing oracle ERP systems in the public sector
Authors: Srikanth G
Published: February 2025

Public sector organizations face serious need to upgrade their Enterprise Resource Planning systems because this upgrade helps them to work more efficiently and serve customers effectively. This paper suggests an innovative plan to include Artificial Intelligence into Oracle ERP systems, which helps improve work processes and makes better decisions while handling automatic repetitive tasks. This framework enables easy modifications to ERP systems through AI while also working with less human action to give improved data insights. The research analyzes ERP system challenges before explaining how AI tools help systems to execute processes faster and more securely plus offering better adaptability. The analysis uses actual practice evidence and numerical data to explain how AI supports government organizations when they transform their Oracle ERPs. Research data proves that digital ERP systems that employ Artificial Intelligence technologies assist companies to work better and make smart transformational digital decisions.
A new alien species record for the Flora of Türkiye: Ipomoea indica (Burm.) Merr. (Convolvulaceae)
Authors: Elmas Emire , Yaşayacak Hasan
Published: February 2025

Ipomoea indica (Burm.) Merr. is an invasive species with a wide distribution in tropical and subtropical regions and its natural habitat is South America. I. indica, which is a new record for the flora of Turkiye, was collected and photographed on 27 June 2022 from Alanya-İncekum. Additionally, the species was observed and photographed in Izmir-Foça, Manavgat-Çenger and Muğla-Bodrum in the Mediterranean and Aegean regions of Türkiye between 27 June 2022 and 02 July 2023. Alanya-İncekum, İzmir-Foça, Manavgat-Çenger and Muğla-Bodrum and taxonomically described. Although this species is morphologically similar to I. purpurea and I. tricolor, I. purpurea differs from I. indica in having smaller flowers (4-6 cm.), shorter sepals (1.1-1.6 cm.) with hirsute surfaces and predominantly unlobed leaves. Similarly, I. tricolor differs from I. indica by having smaller flowers (3.5-6 cm) and sepals that are glabrous, have scarious margins and shorter (6-7 mm). The spread of I. indica, which has the potential to exhibit invasive behavior, risks putting pressure on native plant species and the ecosystem. Therefore, it is important to conduct additional studies to understand the impacts of alien species and determine management strategies.
Comparative anatomy and palynology of two Herniaria L. species (Caryophyllaceae)
Authors: Cömert Yağmur , Koç Murat
Published: February 2025

In this study, the anatomical and palynological features of Herniaria incana Lam. and H. pisidica Brummitt. species were investigated. Similarities and differences were discussed for species. Anatomy and pollen studies of these taxa are presented for the first time in this work. Scanning Electron Microscopy (SEM) and Light Microscopy (LM) studies on the pollen grains have revealed that they are prolate – spheroidal and their exine ornamentation is microechinate – punctate. The stem has a collateral vascular bundle and the mesophyll type is bifacial for both H. incana and H. pisidica.
Lipoic acid confers osmotic stress tolerance to maize seedlings by upregulating the enzymes of antioxidant defense and glyoxalase systems
Authors: Sezgin Muslu Asiye , Terzi Rabiye
Published: February 2025

Exogenous application of lipoic acid (LA), which is a special antioxidant substance, alleviates abiotic stress damage in plants. However, the mechanism of action of LA in stress tolerance is still not fully understood. Here, the effect of exogenous LA on the coordination of antioxidant defense and glyoxalase systems to alleviate osmotic stress damage was investigated. LA (12µM) was applied to the roots of 21-day-old seedlings in Hoagland nutrient solution for 8 hours and then the seedlings were exposed to 10% polyethylene glycol (PEG6000) for 3 days. Seedlings grown in Hoagland nutrient solution for 28 days were used as the control group. Exogenous LA under osmotic stress was found to increase the fresh and dry weights of the leaves, leaf relative water content, and non-enzymatic compounds such as ascorbate and glutathione (GSH) while significantly decreasing the contents of hydrogen peroxide (H2O2) and methylglyoxal (MG). LA application also increased some antioxidant enzyme activities such as ascorbate peroxidase (1.2-fold), glutathione peroxidase (1.3-fold), glutathione reductase (1.4-fold), and monodehydroascorbate reductase (1.8-fold). LA significantly induced the relative expression levels of the genes coding the antioxidant enzymes. Furthermore, LA stimulated the enzyme activities of the glyoxalase system (glyoxalase I (Gly I) (1.3-fold) and glyoxalase II (Gly II) (1.1-fold). Additionally, the relative expression levels of the Gly I and Gly II genes were consistent with the findings of the Gly I and Gly II activities. Moreover, exogenous LA induced the expression level of Gly II (1.4-fold) more than that of Gly I (1.3-fold). As a result, LA mitigates osmotic stress damage in maize by enhancing the activity of antioxidant and glyoxalase systems, enabling the rapid removal of reactive oxygen species and the toxic compound MG, thereby providing a protective mechanism. Further investigation of the effects of LA on crops exposed to abiotic stresses will contribute to improve the stress tolerance and increase agricultural yields.
Antioxidant profiling of Anethum graveolens: Insights into phenolic and flavonoid-rich extracts
Authors: Ayık Burak , Emsen Buğrahan , Doğan Muhammet
Published: February 2025

This study investigates the total phenolic and flavonoid contents, antioxidant activity, and metal chelation capacity of acetone and water extracts from Anethum graveolens L.. The total phenolic content of the acetone extract was significantly higher (173.49 ± 4.91 µg GAE/mg extract) than the water extract (98.52 ± 3.62 µg GAE/mg extract). Similarly, the flavonoid content of the acetone extract (72.81 ± 1.15 µg QE/mg extract) exceeded that of the water extract (27.69 ± 1.72 µg QE/mg extract). Concentration-dependent responses revealed higher antioxidant activity for the acetone extract across all tested concentrations (12.5–400 µg/mL), with a sharper increase in response at higher concentrations. The IC50 values for DPPH radical scavenging and metal chelation activities further confirmed the acetone extract's superior performance, with lower IC50 values for DPPH scavenging (51.56 µg/mL) and metal chelation (113.46 µg/mL) compared to the water extract (192.44 µg/mL and 268.95 µg/mL, respectively). Hierarchical clustering and 3-D surface plot analyses demonstrated strong correlations between DPPH scavenging and metal chelation activities for both extracts, with Pearson correlation coefficients of r = 0.94 for the acetone extract and r = 0.99 for the water extract. While the acetone extract displayed higher bioactivity, the water extract exhibited a more tightly linked relationship between its antioxidant and metal chelation properties. These findings highlight the potential of A. graveolens extracts as natural antioxidants and metal chelators, offering promising applications for oxidative stress mitigation and metal toxicity management.
Peningkatan Kemampuan Pekerja Peternakan Ayam Petelur dalam Identifikasi Bahaya Potensial dan Masalah Kesehatan
Authors: Angraini Dian Isti , Febriani Wiwi , Daulay Suryani Agustina , Nisa Lutfi Khoirun , Ramadhan Rifqi Ihza
Published: February 2025

Peternakan ayam petelur merupakan salah usaha yang banyak ditemukan termasuk di Lampung Selatan. Usaha ini sangat menjanjikan karena permintaan akan telur ayam yang selalu tinggi untuk pemenuhan kebutuhan protein. Pada lingkungan kerja di peternakan ayam petelur memiliki bahaya potensial, yang dapat berupa bahaya fisika, biologi, kimia, ergonomi, maupun psikososial. Pajanan bahaya potensial secara berlebihan menjadi potensi risiko masalah kesehatan berupa gangguan, cedera ataunkerusakan pada tubuh pekerja sehingga diperlukan upaya untuk mengidentifikasi dan menganalisis bahaya potensial yang berisiko untuk menjaga kondisi pekerja dan lingkungan kerja yang aman dan sehat. Tujuan dari kegiatan ini adalah meningkatkan kemampuan para pekerja di peternakan ayam petelur “X” di Lampung Selatan dalam mengidentifikasi bahaya potensial dan masalah kesehatan di lingkungan kerja. Metode yang akan dilakukan adalah dengan edukasi melalui ceramah dan diskusi interaktif, pemutaran video, dan simulasi. Kegiatan ini dilaksanakan selama 3 hari dan bertempat di peternakan ayam petelur “X” Kabupaten Lampung Selatan. Peserta berjumlah 7 orang yang merupakan karyawan dan pimpinan peternakan ayam petelur tersebut. Hasil pengabdian didapatkan bahwa terjadi peningkatan pemahaman peserta sebanyak 85,7% menjadi pemahaman yang baik, 14,3% peserta memiliki pemahaman cukup baik, dan tidak ada peserta memiliki pemahaman yang kurang mengenai identifikasi bahaya potensial dan masalah kesehatan di lingkungan kerja. Hasil kegiatan ini mendapatkan bahwa bahaya potensial yang ada berasal dari ergonomi dan psikologis; Pimpinan peternakan ayam petelur tersebut telah menetapkan waktu untuk melakukan stretching bagi para pekerja dan meningkatkan komunikasi dua arah dalam menghadapi permasalahan yang ditemui. Kesimpulan hasil kegiatan ini yaitu peningkatan kemampuan identifikasi bahaya potensial dan masalah kesehatan di lingkungan kerja ini dapat mencegah pekerja mengalami masalah kesehatan, cedera atau penyakit akibat kerja.
Efektivitas Penerapan Teknologi Informasi Terintegrasi (Mobile dan Website) serta Penggunaan Teknologi Tepat Guna pada Alat Perajang Tembakau
Authors: Vernanda Dwi , Iqbal Mohammad , Susilawati Susilawati
Published: February 2025

Kelompok Tani Caringin yang berada di Desa Cimeuhmal, Kecamatan Tanjungsiang, Kabupaten Subang, tengah menghadapi sejumlah tantangan dalam pengelolaan tembakau. Pengelolaan anggota dan lahan masih dilakukan secara manual, meliputi pencatatan data petani, luas lahan, distribusi bibit dan pupuk, serta perhitungan hasil panen, yang rentan terhadap kesalaha. Selain itu, proses perajangan tembakau yang menggunakan pisau secara manual dinilai tidak efisien, memakan waktu, dan menimbulkan risiko kecelakaan kerja. Di sisi lain, pemasaran produk hanya dilakukan secara lokal dan secara offline, sehingga menghambat potensi peningkatan pendapatan. Kegiatan pengabdian ini memiliki tujuan untuk menangani permasalahan terkait pencatatan manual data kepemilikan lahan kelompok tani, permasalahan kecelakaan dalam perajangan tembakau, dan pemasaran tembakau yang masih dilakukan secara konvensional secara offline. Solusi yang diusulkan mencakup pengembangan sistem informasi berbasis aplikasi mobile untuk mengelola data petani, memantau aktivitas pertanian, serta melakukan penjadwalan otomatis untuk pemupukan dan perawatan tanaman. Penerapan alat mesin perajang tembakau modern akan mempercepat proses perajangan, menghasilkan rajangan yang lebih seragam, dan mengurangi risiko kecelakaan. Untuk memperluas pemasaran, akan dibuat website “tembakaucaringin.com” guna mempromosikan produk tembakau ke pasar yang lebih luas dan memfasilitasi transaksi online. Anggota kelompok tani juga akan diberikan pelatihan mengenai penggunaan sistem informasi, pengoperasian alat perajang, dan pengelolaan website. Hasil pengabdian berupa perancangan aplikasi mobile apps monitoring lahan tembakau, website pemasaran tembakau, dan alat perajang tembakau ini ini diharapkan dapat menjadi solusi untuk meningkatkan produktivitas, kualitas tembakau, serta kesejahteraan ekonomi anggota Kelompok Tani Caringin dan masyarakat sekitar.Kesimpulan dari pengabdian ini adalah kegiatan yang bertujuan untuk meningkatkan efisiensi dan kesejahteraan Kelompok Tani Caringin melalui pengembangan aplikasi mobile untuk manajemen data, alat mesin perajang tembakau, dan pembuatan website pemasaran. Ide gagasan ini diharapkan dapat meningkatkan produktivitas, kualitas tembakau, dan memperluas pasar, serta mengurangi risiko kecelakaan kerja dan kesalahan dalam pengelolaan
Pembuatan Video Promosi untuk Peningkatan Brand Image dan Brand Awareness Desa Wisata Hijau Bilebante
Authors: Faerrosa Lady , Qatrunnada Qatrunnada , Agus Pratama Aryan
Published: February 2025

Perkembangan teknologi informasi, terutama media sosial seperti TikTok, Instagram, dan YouTube, memberikan peluang besar bagi Usaha Mikro, Kecil, dan Menengah (UMKM) dan destinasi wisata untuk mempromosikan produk dan jasa yang dimiliki. Sayangnya, meskipun Desa Wisata Hijau (DWH) Bilebante di Lombok memiliki potensi wisata yang unik, pengelola masih belum memaksimalkan pemanfaatan media sosial untuk promosi, terutama melalui sebuah video. Kegiatan pengabdian ini bertujuan untuk membantu pengelola DWH Bilebante dalam pembuatan video promosi yang dapat dipublikasikan melalui akun sosial media guna meningkatkan brand image dan brand awareness DWH Bilebante. Metode pelaksaan dimulai dari observasi objek wisata, penulisan naskah dan narasi, pengambilan footage, serta editing video. Hasil kegiatan pengabndian berupa video promosi yang menonjolkan keindahan alam dan budaya lokal DWH Bilebante. Video promosi tersebut menunjukkan peningkatan engagement yang signifikan, dengan lebih dari 800 tayangan di Instagram dan lebih dari 80 tayangan di YouTube. Diharapkan, video ini dapat memperkuat brand image DWH Bilebante sebagai destinasi wisata yang ramah, unik, dan kaya akan kearifan lokal, serta menarik lebih banyak wisatawan untuk berkunjung.
KosyFinder E-Commerce System Based on Web Geographic Information System and Expert System
Authors: Hardiana Hardiana , Siaulhak Siaulhak , Jumardi Andi , Iriansa Iriansa
Published: February 2025

Latar Belakang: Permasalahan saat ini mahasiswa maupun masyarakat dalam mencari informasi kos hanya mengandalkan informasi dari teman, kerabat, atau pencarian manual dalam mencari ketersedian kos. Saat ini pula ketersedian platform penyedia layanan informasi untuk kos saat ini sudah bayak, khususnya yang berbasis website maupun yang berbasis android. Layanan informasi kost yang berbasis website maupun berbasis android hanya menyediakan informasi umum terkait dengan informasi kos, belum mampu menyediakan informasi yang komprehensif.
Tujuan: Tujuan penelitian ini yakni mengembangkan platform e-commerce KosyFinder yang terintegrasi dengan Web Geographic Information System (WebGis)  dan Sistem Pakar yang dapat membantu pengguna dalam pemilihan kos sesuai kebutuhan.
Metode : Metode penelitian yang digunakan yaitu Research and Development menggunakan model pengembangan waterfall dan  metode certainty factor (CF) dalam mendiagnosa kesehatan lingkungan pemukiman sekitar kos.
Hasil : Hasil penelitian ini menghasilkan sebuah produk aplikasi e-commerse KosyFinder yang terintegrasi dengan WebGis dan sistem pakar. Hasil pengujian ahli dan pengujian pengguna diperoleh nilai akhir yaitu 3.8 (sangat sesuai) artinya sistem dihasilkan sudah dapat digunakan.
Kesimpulan: Platform yang kembangkan berfungsi dengan baik dan sesuai dengan yang diharapkan sesuai dengan hasil pengujian ahli dan user dengan kategori sangat sesuai.
Web-Based Pistol Storage Security Monitoring System Optimization for Database Effectiveness
Authors: Lukman Nur Rokhim Ahmad , Syafaat Mokhammad , Kasiyanto Kasiyanto , Widiatmoko Dekki , Sridaryono Aguk
Published: February 2025

Background: Gun storage security is an important aspect in supporting operations, but manual monitoring often creates obstacles to the effectiveness and accuracy of gun storage data management.
Objective: The purpose of this study is to optimize the gun storage security monitoring system with web-based technology to improve the effectiveness and accuracy of the database.
Methods: The method used in this study is the development of a web server-based system that is integrated with real-time monitoring features, automatic notifications, cloud-based data storage to facilitate data access and tracking.
Result: The results of this study are the creation of a system that is able to improve the accuracy and responsiveness of gun storage monitoring, as well as improve the efficiency of database management.
Conclusion: In conclusion, the implementation of this web-based system has the potential to reduce security risks and significantly increase the effectiveness of monitoring in gun storage.
Development of an Information System for Admission of New Students Using Waterfall to Increase the Efficiency of Registration
Authors: Faid Mochammad , Setiawan Novaldo Jaka , Alfiandri Yanuar Ricky
Published: February 2025

Background: Problems faced in the previous manual system include long queues, data inaccuracy, and slow administration, which hamper services to prospective students and parents.
Objective: This study aims to improve the efficiency of the New Student Admissions (PPDB) process at Junior High School (SMP) Islam Abdul Wahid through the implementation of an online PPDB website.
Method: The method used in this study is a software development approach with a waterfall model, which includes the stages of needs analysis, design, implementation, and system testing. Research data were obtained through interviews with administrative staff and questionnaires to prospective students and parents. This website is designed using web technologies to ensure reliability and ease of use.
Result: The results of this study are that the online PPDB website is able to speed up the registration process, increase data accuracy, and significantly improve the service system.
Conclusion: The conclusion of this study is that the implementation of the online PPDB website provides an effective solution in improving the efficiency of school administration and can be applied in other educational institutions as a form of digital innovation in the modern era.
Accelerated Fatigue Life Estimation of An Axle Housing
Authors: Aksoy Fatma Dilay , Dağcı Olcay , Çamoğlu Oğuzhan , Balcı Onur
Published: February 2025

In this study, the fatigue test time of an axle housing was aimed to decrease by increasing the testing load without having permanent deformation on the housing. In this concern, the deformation values of the banjo zone of a heavy-duty commercial vehicle welded complete axle housing under static loads were measured with a dial indicator, the elastic behavior of the housing was observed, and the yield limit was tried to be determined. The axle housing underwent vertical fatigue tests under specified elastic loading circumstances, and the housing's fatigue life was examined under progressively higher loading conditions. In parallel with the static and fatigue tests, the stress and displacement values in the axle housing were obtained with the finite element analysis program ANSYS and verified with the test results. Load conditions, test configurations and fatigue life results are described in detail in the article. Considering the preliminary study [1] results, this study went one step further and tried to obtain the optimum load-life relationship that can be applied as accelerated vertical fatigue test condition for verification of an axle housing. In this way, it is aimed to reduce the time spent on fatigue tests and to provide economic benefits by performing tests in fewer cycles with a higher load.
Sobre las precauciones en el uso de los modernos anti-inflamatorios no esteroides
Authors: Acosta de Pérez O.
Published: February 2025

Los analgésicos anti-inflamatorios no esteroides (AINES) son un grupo heterogéneo de compuestos con propiedades analgésicas, antiinflamatorias y antipiréticas. Producen sus efectos farmacológicos al inhibir la enzima cicloxigenasa (COX), que cataliza el primer paso en la síntesis de prostaglandinas (PG) a partir del ácido araquidónico. Existen dos isoformas de dicha enzima.COX1 es responsable de la producción de PG que regulan la hemostasia y cordinan acciones hormonales. Existe en la mucosa gástrica, neuronas y riñones. PGI2, por ejemplo, desempeña un rol fisiológico importante al mantener la perfusión de los riñones. COX2 es inducida en células activadas por exposición a mediadores inflamatorios, promoviendo inflamación, dolor y fiebre. La estimulación provocada por endotoxinas, citokinas y factor de crecimiento, este último importante en el proceso de curación, puede aumentar 20-80 veces el nivel basal de la enzima. En general los AINES inhiben ambas enzimas, pero con diferente intensidad. Algunos inhiben más intensamente a COX1 que COX2 (aspirina, indometacina, ibuprofeno) y otros inhiben de igual manera a ambas isoformas (diclofenac, paracetamol, naproxeno). Nimesulda y meloxican inhiben más a COX2 y celecoxib y rofecoxib (coxibs) actúan casi exclusivamente inhibiendo COX2.
Concentración sérica de minerales con relación al ciclo estral en bovinos Brangus
Authors: Brem J. J. , Mestre J. , Trulls H. E. , Pochon D. O.
Published: February 2025

Muchos analitos pueden variar su concentración sanguínea acorde al estado fisiológico del animal, especialmente aquéllos provocados por fluctuaciones hormonales del medio interno. En este trabajo se evaluó el comportamiento de algunos minerales en sangre durante las distintas etapas del ciclo estral, en una categoría determinada de hembras bovinas de condición corporal muy homogénea. Se utilizaron 38 vaquillonas Brangus (3/4 A.Angus 1/4 Brahman) de 3 años de edad, que no habían recibido servicio reproductivo. Se encontraban sobre potreros de pasto pangola, con aguadas de buena calidad y presentaban un excelente estado nutricional. En el seguimiento del ciclo estral, las muestras de sangre para el dosaje de progesterona fueron tomadas dos veces por semana durante un mes. La concentración hormonal fue determinada por la técnica del radioinmunoanálisis (RIA) con hormona marcada con 125I de alta actividad específica. Hacia la mitad de la prueba, se efectuaron dosajes sanguíneos de cobre, calcio, fósforo inorgánico, hierro y magnesio por espectrofotometría UV–visible. En la mayoría de los animales se registró una actividad ovárica normal con picos de progesterona que en muchos casos superaron holgadamente los 6 ng/ml; solo 4 de ellos presentaron anestros. El análisis de la variancia de los valores bioquímicos, considerados según la etapa del ciclo estral al momento del muestreo, no mostró diferencias significativas en la concentración sanguínea de los minerales considerados. Se concluye que la actividad ovárica, con los cambios hormonales que ella representa, no fue suficiente para modificar las concentraciones sanguíneas de estos minerales, por lo cual no debería ser considerada como variación importante en la interpretación diagnóstica de los resultados.
Determinaciones hematológicas y urinarias en aguará-guazú (Chrysocyon brachyurus) en cautiverio en el nordeste argentino
Authors: Mussart N. B. , Solís G. A. , Arzuaga S. M. , Coppo J. A.
Published: February 2025

El propósito de este estudio fue obtener valores hemáticos y urinarios de este cánido silvestre, actualmente en peligro de extinción, a efectos de compararlos con los intervalos de referencia reportados para animales sanos y así deducir su estado de salud durante el cautiverio. Se reportan valores para unos 30 parámetros del medio interno, registrados sobre 5 ejemplares de aguará-guazú alojados en zoológicos de Chaco y Corrientes. Las concentraciones de algunos analitos resultaron semejantes a las registradas en investigaciones previas (leucocitos, proteínas totales, hematocrito), pero otras difirieron considerablemente. Por no haberse hallado datos previos, no pueden compararse las fracciones electroforéticas seroproteicas, que resultaron semejantes a las del perro doméstico, excepto por tasas más altas de alfa globulinas y presencia de pre-albúmina. Tampoco fueron hallados datos sobre valores urinarios para Chrysocyon brachyurus, algunos de los cuales no difirieron de los publicados para el perro (densidad, pH, ausencia de glucosa). En la orina de algunos ejemplares se detectaron cristales de cistina (cistinuria) y huevos de Capillaria sp y Dioctophyme renale, concomitantes con hematuria, proteinuria, cilindruria y presencia de nitritos, así como elevadas concentraciones séricas de beta globulinas (reactantes de fase aguda) y urea y creatinina (retención nitrogenada). Las elevadas tasas de linfocitos y eosinófilos (defensas activadas) y la baja glucemia descartan la existencia de estrés. La eosinofilia podría relacionarse con las parasitosis antemencionadas. Las reducidas concentraciones de hemoglobina, albúmina, glucosa, colesterol, calcio y fósforo, quizás respondan a estados de subnutrición, y los aumentos de bilirrubina y ALP, acompañados por baja actividad de las enzimas indicadoras de inflamación hepática (ALT, AST, LDH), indicarían una ligera colestasis, tal vez atribuible a la sobrecarga hepática por alimentación inadecuada. Los parámetros estudiados se revelaron potencialmente útiles para indicar diversas enfermedades internas, por lo cual se recomienda su realización para controlar el estado de salud del aguará-guazú en cautiverio.
Estudio histoquímico y ultraestructural de focos de criptas displásicas del intestino grueso inducidos con 1,2–dimetilhidrazina en ratas
Authors: Sánchez Negrette M. , Montenegro M. A. , Lértora W. J. , Borda J. T.
Published: February 2025

El objetivo de este estudio fue verificar cambios histoquímicosy ultraestructurales en los focos de criptas displásicas (FCD) inducidos por el carcinógeno1,2–dimetilhidrazina (DMH) en intestino grueso de ratas. Fueron utilizadas 30 ratasWistar machos, de 3 meses de edad, mantenidas con dieta balanceada (20 experimentales y10 controles). La DMH fue administrada a los animales experimentales por vía subcutáneadurante 16 semanas, a dosis de 20 mg/kg de peso corporal. Luego de la última inoculaciónse sacrificaron todos los animales de ambos grupos. En el intestino grueso se localizaronlos FCD, en los cuales se estudiaron los cambios histológicos e histoquímicos del epiteliointestinal a partir de muestras seccionadas en 5μm, coloreadas con hematoxilina y eosina,PAS y azul alcian a pH 2,5; también fueron examinados mediante microscopía electrónicade barrido. Histoquímicamente los FCD se caracterizaron por disminución o ausencia de lacoloración de mucosustancias neutras y ácidas, reaccionando negativamente al PAS y al azulalcian. Desde el punto de vista ultraestructural se registraron aumentos del tamaño de lascriptas (hiperplasia y crecimiento desorganizado de las células glandulares) y cambios enla superficie, caracterizados por una leve distorsión de las bocas de aberturas de las criptas,aumento del grosor de sus paredes y disminución del número y tamaño de las microvellosidades(menor grado de maduración). Las lesiones halladas indican que la superficie mucosadel intestino grueso de ratas tratadas con DMH desarrolla cambios morfológicos durante lacarcinogénesis, evidenciables antes de la aparición del tumor visible macroscópicamente.