bluuebunny/crossref_metadata_2025 huggingface dataset:
Muscular and Vascular Fallopian Tube Morphology in Ectopic Tubal Pregnancy
Authors: Baxi Seema , Koyani Mitesh , Sabugar Md Hashmi , Pandya Dhwani
Published: May 2024

Background
Although literature is full of articles on histopathological changes in fallopian tube in ectopic pregnancy and the predisposing conditions associated with ectopic pregnancy, none have mentioned or reported abnormal muscle and vascular architecture of the tube. The study was undertaken to find the percentage of different sites of ectopic pregnancies coming to the institute for treatment and to calculate the proportion of various morphological risk factors which could have led to the ectopic pregnancy and to discern the various histopathological changes in cases of ectopic tubal pregnancies.
Methods
A retrospective study was conducted on all the cases of ectopic pregnancies in the year of 2021 and 2022. For comparison of morphological changes equal number of tubes received for tubal ligation were assessed as they served age matching purpose. Hematoxylin & eosin-stained slides were retrieved and re-examined for the histological patterns.
Results
92% of the ectopic pregnancies were tubal pregnancies. Amongst predisposing factors of tubal pregnancies detected morphologically, chronic salpingitis was seen in 71.5% of cases while Salpingitis Isthmica Nodosa (SIN) was seen in 26.1% of cases.
Conclusion
Abnormal morphological findings like tubal muscle splaying, arterial wall thickening leading to grotesque shapes, clear changes in different layers of tunica of blood vessel with or without concentric muscle splaying were seen in tubal ectopic pregnancies in significant numbers of cases.
Dual Invasive Pulmonary Mycosis in a Post Covid-19 Patient: An Autopsy Diagnosis
Authors: Taneja Nitin Sagar , Jadhav Toyaja M , Das Debasheesh , Sen Alok D
Published: May 2024

Patients suffering from Covid19 associated lower respiratory tract infection are most often in an immunocompromised state and are indeed vulnerable to a host of bacterial and fungal infections. Among the fungi, common invaders include candidiasis, aspergillosis and mucormycosis. Aspergillosis is a relatively common fungal infection which has been widely reported to occur in patients suffering from or recently recovered Covid19 infection. The invasive form of this fungus, is, however, less commonly reported in literature. Invasive pulmonary mucormycosis is a relatively uncommon pulmonary fungal disease. Its early diagnosis is essential but difficult as it lacks an effective treatment protocol. Commonly affecting a primarily immunocompromised host, the diagnosis of both infecting fungi primarily rests upon detection of their hyphae and/or spores in the lung and vascular tissue. This report describes presence of invasive pulmonary mucor and aspergillosis detected at autopsy in a post covid 19 patient, who presented with a naso-orbital swelling and had a rather silent clinical course followed by sudden onset of a single episode of massive hemoptysis resulting in his death.
Spectrum of Patterns in Lymph Node Histopathology at A Tertiary Healthcare Centre in Hadoti Region
Authors: Pathak Vandana , Menghani Bhawika , Dhakar Lubhanshi , Sharma Bhoomika
Published: May 2024

Background
Lymph nodes are an integral part of immune system and, being the most widely distributed and easily accessible lymphoid tissue so they are frequently examined for diagnostic purposes. It is necessary to document the spectrum in a particular region to understand the trend and diseases occurring frequently in that region. The aim of this study is to evaluate spectrum of histopathological diagnosis among multiple etiologies of lymphadenopathy.
Methods
This is a retrospective descriptive study undertaken in the Department of Pathology, Government Medical College, Kota of all the lymph node biopsies received in our department over a period of one year from January 2023 to December 2023.
Result
A total of 102 patients were included, out of which females are 60 (59%) cases and males constituted 42 (41%) cases. Most common affected age group was 21-40 years and site was cervical with 42 (41.17%) cases. 54 cases (52.94%) showed changes of reactive lymphadenitis. Hodgkin and non-Hodgkin lymphoma ratio in male to female was 3:1, while that of tubercular lymphadenitis was 3:10. Metastatic squamous cell carcinoma and infiltrating ductal carcinoma was seen contributing to 10 (40%) cases each.
Conclusion
It is evident that most common pattern in lymph node pathology is reactive lymphadenitis, affecting age group 21-40 years, majorly affecting females. Females are mostly involved in cases of tuberculosis with ratio being 3:10. In developing country such as India, this points to frequent population exposure to infections. This could indicate a need to strengthen primary and secondary levels of preventive measures.
HARNESSING THE POWER OF NATURAL LANGUAGE PROCESSING IN NURSING SERVICES
Authors: S. Panchal , P. Thakur
Published: May 2024

Natural Language Processing (NLP) has emerged as a transformative force in healthcare, revolutionizing various aspects of nursing services. This research article explores the applications, benefits, challenges, and future directions of NLP in nursing. Through a comprehensive review, this article highlights the pivotal role of NLP in clinical decision support, health records management, patient interaction, and research synthesis. Real-world case studies illustrate the tangible impact of NLP on improving efficiency, accuracy, and patient outcomes. While acknowledging the advantages of NLP, the article also addresses challenges such as data privacy, model bias, and implementation hurdles. Future predictions envision NLPs evolution towards personalized care, precision medicine, and population health management. The article concludes with a call to action for healthcare organizations to invest in NLP research and collaboration, paving the way for a brighter healthcare future.
ANALGESIC EFFICACY OF ULTRASOUND-GUIDED TRANSVERSUS ABDOMINIS PLANE BLOCK IN PATIENTS UNDERGOING LAPAROSCOPIC APPENDICECTOMY
Authors: K. Joshi Yatri , V. Patel Vidhi , V. Patel Neel
Published: May 2024

Background: This study investigates the analgesic efficacy of ultrasound-guided Transversus Abdominis Plane (TAP) block versus traditional analgesics in Laparoscopic appendicectomy patients. It focuses on pain reduction, opioid side effects, and recovery parameters, aiming to improve postoperative care by integrating more precise and safer regional anesthesia techniques. Methods:This randomized, controlled, double-blinded study at a tertiary care center evaluated the ultrasound-guided TAP blocks analgesic efficacy in patients undergoing Laparoscopicappendicectomy. Adults meeting specific criteria were assigned to receive either the TAP block or standard analgesia. Outcomes measured included postoperative pain intensity, analgesia use, patient satisfaction, recovery metrics, and safety, analyzed via intention-to-treat with statistical significance set at p<0.05. Results:Pain scores with movement differed significantly between the groups. Group A had a low mean VAS score of 0.24 (SD 0.44, range 0-1.0), whereas Group B experienced higher discomfort, with a mean score of 1.88 (SD 0.67, range 1.0-4.0). Over time, Group As pain levels remained low, peaking slightly at 0.80 at 12 hours, then decreasing. Conversely, Group Bs pain increased significantly, peaking at 3.24 at 6 hours and gradually reducing to 1.88 by 24 hours. Group A (TAP Block) required fewer analgesics, averaging 1.28 interventions (SD 0.46) versus Group B (Standard), which needed more, averaging 3.48 (SD 0.51). Conclusion:Ultrasound-guided TAP block reduces pain, analgesic use, and side effects in appendicectomypatients, promising improved recovery outcomes.
CLINICO-EPIDEMIOLOGICAL STUDY OF CUTANEOUS ADVERSE DRUG REACTIONS IN A TERITIARY CARE CENTRE
Authors: Selva SNDL , Meda Susmitha , Vinnakoti Anitha , Bonthu Indira
Published: May 2024

Background: Cutaneous adverse drug reactions (CADRs), sometimes referred to as toxidermia, are skin side effects of systemic medication delivery that affect 0.1-0.3% of patients who visit the DVL department. These responses might be as minor as a drug rash or as serious as life threatening reactions. Aims & objectives: To evaluate the age and sex distribution, clinical types, and offending drugs causing cutaneous adverse drug reactions. Materials and Methods: A retrospective observational study was conducted at the DVL OPD in a tertiary care hospital in Andhra Pradesh for a duration of 1 year from January 2023 to December 2023, a total of 90 patients with cutaneous drug reactions were noted. Results: In this study, there was female dominance (46%) and most of the patients were in their 30 to 50 years of age group(62.2%) with fixed drug eruption (64.4%) being the most common clinical profile of CADRs, followed by erythema multiforme(8.88%), lichenoid drug eruption (7.77%), acneiform eruption(6.66%), maculopapular eruption (5.55%), urticarial rash (2.22%), keratolysisexfoliativa(2.22%),and SJS/TEN(2.22%). The most culpable group of drugs causing CADRs were antibiotics (40.28%), NSAIDs (28.43%), and anticonvulsants (11.6%). Conclusion:Commonly used drugs like antibiotics and NSAIDs can cause cutaneous adverse drug reactions(CADRs). Hence judicious use of these drugs with necessary caution would be highly beneficial.
EFFECTIVENESS OF SELF INSTRUCTIONAL MODULE ON KNOWLEDGE REGARDING AGGRESSIVE BEHAVIOUR AND ITS PREVENTION AMONG ADOLESCENTS IN SELECTED P. U. COLLEGES AT VIJAYAPUR
Authors:   M.Sc (N), Ph.d, Professor/ HOD. Department of Mental Health Nursing, Tulza Bhavani College of Nursing, Vijayapur., a Nelson , Patil Suresh ,   M.Sc (N), Ph.d, Associate Professor. Department of Mental Health Nursing, Government college of Nursing, BIMS, Belagavi., Varghese Aleyamma ,   M.Sc (N), Lecturer. Department of Child Health Nursing, BLDEAs Shri BM Patil Institute of nursing sicences, Vijayapur., Kambale Anita ,   M.Sc (N), Lecturer. Department of Child Health Nursing, BLDEAs Shri BM Patil Institute of nursing sicences, Vijayapur.
Published: May 2024

Background: Approximately 20% of the population in India consists of adolescents. Adolescence can be defined as a developmental period that serves as a bridge between childhood and maturity. The current stage of growth and development is characterized by a state of vulnerability. Methodology: A quantitative approach with pre experimental one group pretest post test design was adopted for the study. The samples from the selected PU colleges of Vijaypura district were selected using convenient sampling technique. The sample consisted of 60 PU college students. The tools used for data collection was knowledge questionnaire. Results: The study result reveal that, pre tests knowledge score mean was 20.4 and mean post tests score was 26.5. In pretest 8(13.3%) of Adolescents were had Inadequate Knowledge, 42(70.0%) of them were had Moderate Knowledge and 10(16.7%) of them were had Adequate Knowledge and in post test 12(20.0%) of them were had Moderate Knowledge and 48(80.0%) of them were had Adequate Knowledge.A significant difference will be found between the pre test and post test knowledge scores of the adolescents regarding Aggression behaviour and its prevention at 0.05 level of significance. Conclusion:Self instructional module improved the knowledge level of the participants. Since a very few studies have been conducted regarding this topic in India, so the nurse researcher can take further studies on the same topic.
MANAGEMENT OF GROSSLY DECAYED PRIMARY ANTERIORS USING VARIOUS INTRACANAL POST SYSTEMS: AN IN VIVO STUDY
Authors: a Ridhima , Singh Dua Parminder , Mangla Ritu , a Neha , Vyas Divya , Cheday Gurung Karma , Devi Nisha
Published: May 2024

Restoration of severely decayed primary maxillary anterior teeth is a big challenge to the pediatric dentist. For the management of such teeth, pedodontists must use intracanal posts such as prefabricated, orthodontic wire in Î± or Î© forms, metallic posts with macroretention, short posts with composite resin, polyethylene ribbon posts, and biologic posts.A total of 30 severely decayed primary maxillary anterior teeth from children aged 3 to 5 years with atleast one-third of the root present were selected. The teeth were randomly divided into 3 groups: Group1(Omega Post), Group 2(Biological Post) and Group 3(Glass Fibre Post). Retention, marginal adaptation and marginal discoloration were clinically evaluated during follow up of 3,6 and 9 month intervals.The results showed a significant difference in retention of Group I when intragroup comparison between baseline and 9 months time intervalwas done. However there was statistically non significant difference in retention of group II and III. A non significant result was seen in marginal adaptation and marginal discoloration of all three groups. Hence it was concluded that glass fibre post showed excellent results which allows its recommendation for management of grossly decayed anteriors with better esthetics and minimum discomfort to children.
A CRITICAL STUDY ON THE IMPORTANCE OF SCHOOL VOLUNTEERING AND SOCIAL WORK TO INCREASE ACADEMIC SUCCESS
Authors:   Professor, Department of Social Work, Mahatma Gandhi Kashi Vidyapith, Varanasi, India., Verma Bhavna , Giri Sandeep ,   Associate Professor, Department of Social Work, Mahatma Gandhi Kashi Vidyapith, Varanasi, India.
Published: May 2024

This important investigation explores the crucial contribution that social work and school volunteering make to improving pupil achievement. The investigation successfully reveals a substantial positive association between active school volunteering and engagement in social work programmes and higher academic success through a thorough analysis that uses both descriptive and regression approaches. According to a descriptive analysis, students who volunteered at their schools had better attendance, more involvement in class, and greater quantities of motivation, all of which contributed to their achievement in school. This association was clarified using regression analysis, which also demonstrated that social work and active involvement in school volunteerism had a beneficial effect on students GPAs.
“Das Floß der Medusa”: About Problem of Henze’s Political Engagement
Authors:   Gnesin Russian Academy of Music, Ryzhinsky Alexander S.
Published: May 2024

The article is devoted to one of the most famous works of H. W. Henze “Das Floß der Medusa” (“The Raft of Medusa”), often seen as an example of Henze’s political engagement. The author of the article concludes that the oratorio was recognized as a political composition in large part due to the accompanying circumstances of its creation and premiere, but not based on the original idea and its realisation. The author demonstrate “Das Floß der Medusa” like a example of the protest music as a direction that exposes not only fascism, but also any form of social inequality, violence against the person. The study of the features of choral style of “Das Floß der Medusa” reveals parallels in the textural structure between Henze’s oratorio and Nono’s works of the 1950s (“La victoire de Guernica”, “Il canto sospeso”, “Intolleranza 1960”). The use of political text resources, the operation of individual syllables and phonemes of a literary text, work with multilingual verbal rows, the active use of diagonal texture — all this brings together the choral works of two contemporaries. At the same time, Henze’s composition also reflected the searches in the field of vocal timbre, characteristic of other composers of Darmstadt Summer Course — the use of various modifications of speech singing (Sprechgesang), the latest techniques of vocal articulation (vocal tremolo, prolongation of the anterolingual vibrant). All this together allows us to talk about Henz’s oratorio as one of the most peculiar choral compositions of the late 1960s.
Facilitating listeners’ understanding of scientific knowledge in TED Talks: A corpus-based analysis of code glosses as metadiscourse resources of popularization
Authors:   Irkutsk National Research Technical University, Boginskaya Olga A.
Published: May 2024

A considerable amount of research has established that media discourse is an interactive event whose success and efficiency depend on speaker-listener relationship. Yet the nature of this interaction has been explored in a great number of studies, few works deal with how TED speakers address the needs of their listeners and manage the interaction with them. TED is considered to be one of the new ways of spreading scientific information online. Due to being an emerging genre, TED Talks have barely been analyzed in terms of popularization tools used to facilitate listeners’ comprehension of materials presented by TED speakers. Drawing on a corpus of 80 transcripts of TED Talks derived from the ted.com website, this study explores how TED speakers elaborate their ideas to address listeners’ needs. The aim of this research is to explore the types of code glosses, their lexical realizations, pragmatic functions and frequencies of occurrence. In order to explore the types and frequency of code glosses employed in TED lectures, the present study applied the quantitative method. With the aim of identifying the pragmatic functions the code glosses serve in TED Talks, the study applied the interpretative method. The analysis of the corpus revealed that code glosses are a crucial element of expert-lay interactions serving the popularization function. Two types of code glossing were employed by TED speakers with the predominance of exemplifiers intended to facilitate listeners’ comprehension and make speaker’s ideas accessible through illustration or scenario-based elaboration. All code glosses found in the corpus serve the popularization purpose which indicates that TED speakers made attempts to recontextualize scientific content and make specialized concepts comprehensible for a lay listener.
Roman law in the jurisprudence of Russian courts
Authors:   St. Petersburg State University, Rudokvas Anton D. , Fedorova Olga A. ,   St. Petersburg State University
Published: May 2024

In modern Russian judicial practice, the justification of court decisions by normative provisions extracted from all that is collectively embraced by the concept of “soft law” is becoming increasingly widespread. In this article, this phenomenon is revealed in the aspect of the practical application by Russian courts of certain provisions of Roman law. Considering specific examples of this kind, the authors, through doctrinal reflection, seek to identify common reasons that encourage domestic courts to turn to the mentioned source of “soft law” and come to the conclusion that modern Russian civil law in a sense repeated the path that was traversed by the civil law of imperial Russia. If, back in the middle of the 19th century, the judiciary could not even think of looking for a source of inspiration anywhere other than a literal interpretation of the text of the law, then with the beginning of the “Great Reforms” of the 1860s, the unsuitability of such an approach for servicing the rapidly developing turnover was revealed, and since the legislator could not keep up with its development, the main work of adapting positive law to changing relations was accepted the courts have assumed much broader discretionary powers. Since the possibilities of the domestic doctrine to meet the needs of the law enforcement officer in understanding and developing Russian law turned out to be very limited, judges found themselves in demand for the European civilian tradition based on Roman law, familiarity with which prompted them to independent judicial law-making. In many ways, similar processes are observed in post-Soviet Russia, a visible manifestation of which is the expansion of “soft law” into law enforcement practice, primarily through an appeal to the analogy of law and teleological interpretation. One of the facets of this process is the revival of interest in the legacy of Roman law and the Romanistic tradition. In this sense, unexpected parallels are found with the development of the common law.
The constitutionalisation of private law: Comparative analysis
Authors:   Constitutional Court of the Russian Federation, Kornilina Polina
Published: May 2024

This article is divided into four parts. The first part discloses the definition of constitutionalisation of private law, which means the influence of fundamental (constitutional) human rights on private law. The second part is devoted to the analysis of the key issue related to the topic of constitutionalisation of private law — how and to what extent fundamental (constitutional) human rights influence private law. In this regard, the four models of private law constitutionalisation identified in comparativism and the pro/contra arguments for each of them are examined. The third part of the article examines which of these models is embodied in foreign legal orders (in particular, Germany, the Neatherlands, Canada, South Africa and the UK). The author concludes that the most widespread is the model of indirect influence of fundamental human rights on private law. The fourth part of the article provides a comparative legal analysis of the application of the indirect model of constitutionalisation. This model identifies two approaches that characterise the attitude of foreign lawmakers to human rights provisions in different ways. The first approach, the “strong” indirect model, assumes that human rights provisions enshrine rights that constitute binding rules. This approach is represented in particular in the UK. The second, the “weak” indirect model, views human rights provisions as enshrining values and being principles to be taken into account alongside other circumstances. This approach is represented in particular in Germany.
Prácticas sustentables, alternativas para la conservación del suelo en Agave tequilana Weber
Authors: Guevara-Gutiérrez Rubén Dario , Mancilla Villa Óscar Raúl , Olguín-López José Luis , Torres-Romero José Gerardo , Rosales-Almendra Manuel Pío , Barreto-Garcia Oscar Arturo , Palomera García Carlos , Avelar Roblero Juan Uriel , Hernández Vargas Omar
Published: May 2024

En la escala comercial, las plantaciones de agave azul tequilero (Agave tequilana Weber var. azul) han requerido grandes extensiones de tierra para satisfacer demandas del mercado, plantado como monocultivo extensivo a fin de producir la materia prima para la elaboración de tequila. En la región Sierra de Amula, Jalisco, el agave azul es plantado en diversos tipos de suelo e inclinaciones de pendiente (3 a >45%), que adicional al trazo de surcos a favor de la pendiente, hace suponer el incremento de tasas erosivas del suelo y agua. Esta práctica en el municipio de Autlán de Navarro, Jalisco, ha modificado el uso del suelo, la agricultura de temporal y cambios sustanciales de actividades agrícolas tradicionales, que, por desconocimiento de su manejo, los agricultores independientes a las compañías de agave-tequila, plantan este cultivo por imitación con mínima o nula asesoría técnica. El objetivo del estudio fue dar conocer el efecto del manejo tradicional al cultivo de agave tequilero sobre la pérdida de suelo, en comparación a la implementación de prácticas sustentables (labranza de conservación y cultivo de cobertura) como alternativa a la conservación del suelo durante el ciclo de lluvias. La unidad de muestreo fueron lotes de escurrimiento (2 m por 5 m). La precipitación pluvial promedio anual del municipio fue de 631.5 mm, en manejo tradicional generó 1531.9 m3 ha-1 de escorrentía superficial y pérdida de suelo de 21.3 t ha-1, esto fue 74% y 96% respectivamente, superior en relación con labranza de conservación, pero similares con relación al cultivo de cobertura en relación con la escorrentía (superior con 4%) pero inferior en pérdida de suelo (32%). En conclusión, se identifica que el manejo de cultivo tradicional, intensifica la degradación del suelo y agua, además del efecto directo de aplicar herbicidas de amplio espectro, así como del trazo del surcado a favor de la pendiente
Natural Compounds that Modulate Circadian Rhythms
Authors: TOMITA Tatsunosuke , Wadhwa Renu , Onishi Yoshiaki
Published: May 2024

Circadian rhythms of innate 24 h cycles comprise well-conserved biological phenomena
from cyanobacteria to mammalian. They are driven by light and regulated by clock genes that
work as transcription factors and control the expression of many other genes and physiological
functions in the cells. The expression of ~ 40% of protein-coding genes shows 24 h oscillation patterns
in mice, implying their importance in normal body functions. Indeed, the physiological and
behavioural rhythmicity generated through clock genes-mediated multiple mechanisms affects the
quality of life at large. Disrupted circadian rhythmicity is associated with several kinds of diseases.
For example, cancer cells show abnormal expression patterns for circadian rhythm genes that
have been shown to regulate oncogenesis, drug responses, and disease prognosis. Furthermore, the
modern globalisation of human lifestyle and business and social activities have disrupted innate
circadian rhythm, resulting in a variety of diseases through disrupted humoral, immunological,
and neuronal pathways. Safe and sustainable modulation of circadian rhythm has become a prevalent
need that warrants basic and interventional research, as well as clinical investigations. Although
traditional systems of medicine suggest some natural compounds with circadian rhythmmodulating
potential, most of these have not been validated in laboratory or clinical studies. Reliable
read-outs of the effects of test compounds on circadian rhythmicity have been limited by the
availability of live cell assays. We have, herein, provided an overview of living cell-embedded real-
time reporter gene assays designed for screening compounds that modulate circadian rhythm,
and discussed the potential of some natural compounds for circadian rhythm modulation as validated
by cell-based assay systems, and their role in disease therapeutics.
Benzimidazole as a Privileged Scaffold in Drug Design and Discovery
Authors: Kumar Ram , Marianesan Arockia Babu , Pathak Shilpi
Published: May 2024

Benzimidazole is a privileged drug design and discovery scaffold with various phar-macological activities, including antimicrobial, anticancer, antitubercular, anti-inflammatory, an-tidiabetic, antihypertensive, antimalarial, and many more. This scaffold can be observed in the structure of numerous FDA-approved drugs and employed in medicinal chemistry to develop novel bioactive compounds through rational drug design. Its broad pharmacological significance is due to physicochemical attributes, including H-bond donor-acceptor efficiency, π-π stacking interactions, and hydrophobic interactions; these characteristics enable benzimidazole derivatives to bind with macromolecules efficiently. This article emphasizes mechanisms, SAR, and docking studies to unveil benzimidazole's various active hybrids accountable for diversified activities. It will assist researchers in strategically designing various novel benzimidazole-endowed hybrids to develop clinically active therapeutic candidates.
Physicochemical Properties of Quinoa (Chenopodium quinoa Willd.) Protein Isolated from Black, Q12, and Titicaca Seed
Authors: Sekhavatizadeh Seyed Saeed , Hosseinzadeh Saeid
Published: May 2024

Background:

Quinoa was cultivated in different parts of the world because of the water
crisis. On the other view, proteins from plant sources have attracted significant interest. One of the
sustainable protein sources is quinoa protein.

Objective:

The aim of this study was to isolate quinoa protein and determine physicochemical
properties for its use in the food industry.

Methods:

Quinoa Protein Isolates (QPIs) were separated from Quinoa Seed (QS) varieties (Black-
-QS, Q12-QS, and Titicaca-QS). The particle size, FTIR, SEM, emulsion activity and stability,
protein solubility, and gelation properties were assessed.

Results:

The Q12-QPI had the highest average particle size, 945 μm. The Black-QPI and Titicaca
(T)-QPI had a higher protein content (87.32 ± 1.93, 87.84 ± 1.62% w/w), respectively, and a more
condensed structure. The surface morphology of Black-QPI and T-QPI showed regular flat and
compact surfaces with some small aggregates. Black-QPI had the most negative zeta potential
charge (-38.8 ± 0.03) and stability among the TQPIs. Emulsion capacity was equal among the samples,
but emulsion stability was the greatest value (34.48 ± 8.1) in T-QPI. The protein solubility ratio
was 70.72, 70.0, and 69.27% in Q12-QPI, T-QPI, and Black-QPI, respectively. The higher elastic
performance of Q12-QPI and T-QPI than Black-QPI was seen during the heating steps in the
gelation stage.

Conclusion:

The suitable nutritional and functional resources of Titicaca quinoa protein make it
an appropriate candidate to use as a safe food additive.
Targeted Therapy of Tumors and Cancer Stem Cells based on Oxidant-Regulated Redox Pathway and its Mechanism
Authors: Wang Shunshun , Han Juanjuan , Wang Zijun , Liu Xianqiong , Wang Chunli , Nisar Muhammad Farrukh , Pan Lianhong , Xu Kang
Published: May 2024

A malignant tumor is a frequent and common disease that severely threatens human
health. Many mechanisms, such as cell signaling pathway, anti-apoptosis mechanism, cell stemness,
metabolism, and cell phenotype, have been studied to explain the reasons for chemotherapy,
radioresistance, and tumor recurrences in antitumor treatment. Cancer stem cells (CSCs) are
important tumor cell subclasses that can potentially organize and regulate stem cell properties.
Growing evidence suggests that CSCs can initiate tumors and constitute a significant factor in
metastasis, recurrence, and treatment resistance. The inability to completely target and remove
CSCs is a considerable obstacle in tumor treatment. Therefore, drugs and therapeutic strategies
that can effectively intervene with CSCs are essential for the treatment of different tumor types.
However, the current strategies and efficacy of targeted elimination of CSCs are very limited.
Oxidative stress has been recognized to play a crucial role in cancer pathophysiology. Moreover,
reactive oxygen species (ROS) production and imbalance of the built-in cellular antioxidant
defense system are hallmarks of tumor and cancer etiology. The current paper will focus on the
regulation and mechanism behind oxidative stress in tumors and cancer stem cells and its tumor
therapy applications. Additionally, the article discusses the role of CSCs in causing tumor
treatment resistance and recurrence based on a redox perspective. The study also emphasizes
that targeted modulation of oxidative stress in CSCs has great potential in tumor therapy,
providing novel prospects for tumor therapy.
The Effects and Safety of Silymarin on β-thalassemia in Children and Adolescents: A Systematic Review based on Clinical Trial Studies
Authors: Rahimi-Dehkordi Nasim , Heidari-Soureshjani Saeid , Sherwin Catherine MT
Published: May 2024

Background:

β-thalassemia imposes significant complications on affected patients. Silymarin,
a natural flavonoid complex, has potential therapeutic properties.

Objective:

This systematic review aims to comprehensively evaluate the literature on the mechanistic
effects of Silymarin on β-thalassemia outcomes in children and adolescents.

Methods:

A systematic search of electronic databases, including MEDLINE/PubMed, Embase,
Scopus, Cochrane Library, and Web of Science (WOS), was done to identify relevant clinical
trials before January 2024. Various data were extracted, including study characteristics, outcomes
measured (hematological parameters, oxidative stress markers, iron metabolism, and other outcomes),
proposed mechanisms, and safety.

Results:

By iron chelation effects, Silymarin can reduce reactive oxygen species (ROS) production,
increase intracellular antioxidant enzyme glutathione (GSH), and insert antioxidant effects. It
also attenuated inflammation through reduced tumor necrosis factor-alpha (TNF-α), transforming
growth factor-β1 (TGF-β1), interferon-gamma (IFNγ), C-reactive protein (CRP), interleukin 6
(IL-6), IL-17, and IL-23 levels and increase in IL-4 and IL-10 levels. By reducing iron overload
conditions, Silymarin indicates modulatory effects on immune abnormalities, inhibits red blood
cell (RBC) hemolysis, increases RBC count, and minimizes the need for a transfusion. Moreover,
it reduces myocardial and hepatic siderosis, improves liver function tests, and modifies abnormal
enzymes, particularly for aspartate transaminase (AST), alanine transaminase (ALT), alkaline
phosphatase (ALP), total bilirubin, and total protein levels. Silymarin also reduces iron overload,
increases antioxidant and anti-inflammatory capacity in cardiomyocytes, and reveals antioxidant
effects.

Conclusion:

Silymarin indicates promising effects on various aspects of children and adolescents
with β-thalassemia and has no serious side effects on the investigated dosage.
Multimodal Deep Learning for Cancer Survival Prediction: A Review
Authors: Zhang Ge , Ma Chenwei , Yan Chaokun , Luo Huimin , Wang Jianlin , Liang Wenjuan , Luo Junwei
Published: May 2024

Background::

Cancer has emerged as the "leading killer" of human health. Survival prediction
is a crucial branch of cancer prognosis. It aims to estimate patients' survival risk based on
their disease conditions. Accurate and efficient survival prediction is vital in cancer patients' treatment
and clinical management, preventing unnecessary suffering and conserving precious medical
resources. Deep learning has been extensively applied in cancer diagnosis, prognosis, and treatment
management. The decreasing cost of next-generation sequencing, continuous development of related
databases, and in-depth research on multimodal deep learning have provided opportunities for establishing
more functionally rich and accurate survival prediction models.

Objective::

The current area of cancer survival prediction still lacks a review of multimodal deep
learning methods.

Methods::

We conducted a statistical analysis of the relevant research on multimodal deep learning
for cancer survival prediction. We first filtered keywords from 6 known relevant papers. Then, we
searched PubMed and Google Scholar for relevant publications from 2018 to 2022 using "Multimodal",
"Deep Learning" and "Cancer Survival Prediction" as keywords. Then, we further searched
the related publications through the backward and forward citation search. Subsequently, we conducted
a detailed analysis and review of these studies based on their datasets and methods.

Results::

We present a comprehensive systematic review of the multimodal deep learning research
on cancer survival prediction from 2018 to 2022.

Conclusion::

Multimodal deep learning has demonstrated powerful data aggregation capabilities and
excellent performance in improving cancer survival prediction greatly. It has made a significant positive
impact on facilitating the advancement of automated cancer diagnosis and precision oncology.
Quantum Dots: Chemistry, Properties, and Energy Storage Applications
Authors: Das Himadri Tanaya , Balaji T. Elango , Dutta Swapnamoy , Das Payaswini , Das Nigamananda
Published: May 2024

Currently, Quantum dot nanomaterials have received a lot of attention due to
their intriguing features. Most intriguing is how they can be used as electrodes to create
safe chemical-free supercapacitor parts and produce clean energy. Due to their high
charge storage capacity and stability, quantum dot electrodes are increasingly in
demand for high-tech hybrid supercapacitors. This chapter covers the electrochemical
performance, physiochemical characteristics, and synthesis of numerous quantum dots.
They are also provided with information about the electrochemical characteristics of
various supercapacitors. To show readers the potential of this field of study, the best
operational factors are highlighted.
MXene: Chemistry, Properties, and Energy Storage Applications
Authors: Devi Manisha , Jaswal Shipra , Kumar Swadesh
Published: May 2024

The growing interest and demand for energy storage applications have
significantly encouraged the development of a broad range of functional 2D materials.
Owing to the extraordinary properties including 2D lamellar structure, larger interlayer
space, mechanical strength, high thermal and electrical conductivity, and negative zetapotential, carbides/nitrides/carbonitrides of transition metal, usually known as MXenes
have received the interest of researchers in the development of environmentally
friendly materials for storage and conversion of energy. In this chapter, we focused on
the MXene, their methods of preparation, the progress of development of various
MXenes, and their modification for the storage of energy. Here, we have discussed the
various storage devices for energy including batteries and superconductors. This
chapter offers scientific inspiration and literature for the rational design and synthesis
of high-capacity MXenes and their composites that can fulfill the increased demand for
next-generation energy storage devices.
Oxazole, Oxadiazole, Isoxazoline and Oxazoline Derivatives as Anti-Inflammatory Agents
Authors: Keertika Bentham Science Publisher , Sharma Nutan
Published: May 2024

Oxygen and Nitrogen containing five-membered heterocyclic compounds
have been the target of intense investigation in the last two decades to discover potent
biologically active compounds as anti-inflammatory agents. The related studies
comprising of fascinating oxazole-based derivatives include oxazoles, isoxazoles,
oxazolines, and oxadiazoles, as therapeutic agents, which have become an interesting
topic.Therefore, noticeable achievements have been accomplished in the field of antiinflammatory studies. This chapter will discuss some latest updates on the synthesis
and anti-inflammatory studies of these oxazole-based derivatives, which we hope will
be beneficial to synthetic organic and medicinal chemists.
The Dynamic Effect of Trade Openness, Debt, and Foreign Investment in Ghana’s Economy: An ARDL Bound Testing Approach
Authors: Yeboah Evans , Lamin Ceesay
Published: May 2024

The impact of macroeconomic factors offers insight into the performance of an economy. This study investigates the dynamic short- and long-term effect of trade openness, external debt, and foreign direct investment (FDI) within Ghana's economy. Utilizing Autoregressive Distributed Lag (ARDL) bound testing and Granger causality analysis, the study examines data spanning from 1991 to 2022. The results of the ARDL cointegration test reveal a long-term relationship among the variables. However, in the short term, the findings present a mixed effect of FDI and trade openness, with both positive and negative impacts. In the long run, FDI and external debt exhibit a positive influence, whereas trade openness appears to impede economic growth. Furthermore, the Granger causality test identifies a unidirectional causality relationship between the variables and economic growth. The study suggests that the government implement investment-oriented and trade policies to stimulate economic growth.
VIRTUAL REALITY (VR) GEOGRAPHIC INFORMATION SYSTEM (GIS) MODEL TO PROMOTE RURAL TOURISM PRODUCT IN PERAK TENGAH DISTRICT
Authors: Abdul Rahman Norainah , Samsudin Mohammad Kamarul Izham , Isa Mohd Ismail , Mohamad Muhammad Rijal , Rahmat Arina
Published: May 2024

Perak Tengah District is not stated as an important tourism cluster in Perak. Nevertheless, Perak Tengah has tourism resources that need to be highlighted as an alternative for rural tourism. The main issue is that Perak Tengah district's tourism resources have not been effectively advertised or utilised, nor have there been any formal digital tourism marketing activities been put into place. The mixed method study was used to identify potential rural tourism products and to obtain the opinion of local operators on how to market the tourism products. The evaluation of rural tourism in terms of goods and destinations in Perak Tengah Districts is the main emphasis of this paper. The findings show that marketing and promotion have emphasised on strengthening local business environments and cultivating strong stakeholder ties. The adoption of Virtual Reality Geographical Information System (VRGIS) model by Perak Tengah District in developing the tourism roadmap or ‘Peta Pelancongan’ is to encourage communication and data exchange which are the essential elements for its success. For future research, the extension of developing a comprehensive application for rural tourism products in Perak Tengah District should be considered.
THE PARADOX OF THE REN: A LOOK AT REAL ESTATE NEGOTIATOR (REN) PRACTICES IN MALAYSIA
Authors: Kien Hwa Ting , Ahmad@Baharum Zarita
Published: May 2024

This paper explores the findings of a focus group discussion held to examine the current state of Real Estate Negotiator (REN) practice in Malaysia. RENs, acting as representatives of estate agencies, play a crucial role in facilitating property transactions. However, the discussion revealed significant ambiguities surrounding their responsibilities, ethical considerations, and the efficacy of the REN Tag system. Participants recounted instances of misrepresentation of property details, inflated rental/prices, and deceptive marketing activities. This highlighted the need for stronger measures to promote ethical conduct within the profession, including awareness campaigns, stricter disciplinary measures, and a robust complaint mechanism.
QUALITATIVE RESEARCH CHALLENGES IN ASSESSING RAINWATER HARVESTING IMPLEMENTATION FIDELITY FOR RELIABLE DATA
Authors: Mohd Latif Hafizah , Mohamed Norazida , Donyavi Sohrab , Samsudin Noor Sahidah
Published: May 2024

Assessing local councils’ adherence to rainwater harvesting policy regulated in the by-laws is critical to the success of water conservation efforts. However, there are certain challenges that must be addressed in this assessment. This paper highlights the aforementioned challenges and provides recommendations for future research. The research used a qualitative approach, employing six distinct methods to obtain more robust and reliable data: (i) desk study, (ii) document review, (iii) interviews, (iv) observation, (v) self-analysis questions and (vi) focus group discussion. The success of the implementation-focused research was based on a defined direction of assessment, eligible participants and sites, suitable methods, access to reliable data, robust analysis and writing proficiency. This paper suggests that future search should focus on establishing relevant skills, building relationships with the participants, defining concepts and exploring alternative data sources. Assessing implementation fidelity was not easy because it necessitated substantial resources to draw meaningful conclusions about the extent to which the rainwater harvesting policy was delivered. Addressing qualitative research challenges in assessing rainwater harvesting implementation could enable researchers to suggest implementers on making more informed decisions in attaining Sustainable Development Goal 6.
THE FACTORS INFLUENCING THE SUCCESS OF BOUTIQUE HOTELS IN KLANG VALLEY, MALAYSIA
Authors: Ab Majid Rohayu , Said Rosli , Omar Mohd Don , Wahid Nurdiana , Rosman Siti Hasniza
Published: May 2024

Boutique hotels, despite not matching the service level of 5-star counterparts, remain a flourishing presence in the hospitality industry, drawing a substantial influx of visitors. This study is dedicated to dissecting the contributory impact factors driving the triumph of boutique hotels in Malaysia. Delving into seven primary dimensions, these are further elaborated into a comprehensive framework of 28 sub-factors. Collated through a 210-strong questionnaire survey, the data collection was centred on patrons of boutique hotels situated in Malaysia's Klang Valley region. Employing inferential analysis techniques, the research probes the significance of these factors in shaping the fortunes of boutique hotels in the Malaysian context. The dataset underwent Chi-Square analysis to ascertain the noteworthy significance attached to each sub-factor. Notably, findings underscore that among the 28 scrutinised sub-factors, a notable set of 17 sub-factors establish a substantial correlation with visitor preferences, exerting a pivotal role in the overarching triumph of boutique hotels within Malaysia.
KEY HOUSING CONDITIONS THAT DIMINISH HEALTHY HOMES AMONG ABORIGINAL COMMUNITIES IN ROYAL BELUM PARK MALAYSIA
Authors: Mohd Latif Hafizah , Essah Emmanuel
Published: May 2024

Research on healthy homes has been carried out relatively little in Malaysia. The aim of this paper is to establish the relationship between key architectural elements of Aboriginal homes in Sungai Kejar, the Royal Belum State Park, and their potential health risks. The data were drawn through naturalistic observation, unstructured interviews and semi-structured interviews. Despite their green features, many Aboriginal homes lack water-tight measures, sanitation facilities and proper flooring - making the people more susceptible to diseases like Leptospirosis and Malaria. Due to their nomadic lifestyle, the people construct temporary homes using green materials like bamboo and leaves. The government-provided wooden and brick houses did not meet most of their preferences primarily due to their lifestyle, culture and belief system. These underlying issues necessitate a thorough evaluation and research to propose optimal construction methods that meet the bare minimum criteria for healthy homes while also accommodating their lifestyle and preserving cultural heritage. This could include introducing brick flooring, portable rainwater harvesting for clean water supply and healthy homes awareness campaigns.
BEST PRACTICES IN ENSURING NATURAL JUSTICE IN ADJUDICATION PROCEEDINGS
Authors: Ahmad Nurlee Azizah , Ismail Zulhabri , Judi Siti Suhana , Sui Pheng Low
Published: May 2024

This study explores the interplay between natural justice principles and adjudication within the Malaysian construction industry, focusing on challenges under the Construction Industry Payment and Adjudication Act (CIPAA). It assesses the impact of CIPAA on natural justice through a review of case law from 2014 to 2017, highlighting 11 key cases where adherence to natural justice was questioned. The study proposes best practices, including Obtaining agreement from the claimant for the request to extension time by the respondent to enhance fairness and reduce legal disputes in adjudication.
Big Bang Theory
Authors: Julie A. , Sangeetha B. , Mary M. Sabeena Margaret , Priya P. , Anusuya V. , Subashini P.
Published: May 2024

Abstract
In 1927 a Belgian cosmologist and a catholic priest George Lemaitre proposed the Big Bang Theory. It explains about what happen for Bang that occurred 13.8 billion years ago. The Big Bang is how astronomers explain the way the universe began. Researches say that universe is still expanding. What causes the acceleration? Big Bang theory explains it. The earliest times of the universe lasting from approximately 10-43 to 10-11seconds after the Big Bang. According to Big Bang Theory all matter in the universe were concentrated as single extremely dense and hot free ball. Scientists like Stephen Hawking, George Elis and Roger Penrose have studied and researched on the Big Bang Theory. Big Bang hypothesis states that “All of the current and past matter in the universe came into existence at the same time”.