bluuebunny/crossref_metadata_2025 huggingface dataset:
Abstract SY44-02: ECM remodeling at the pre-metastatic niche
Authors: Erler Janine T.
Published: July 2016

The extracellular matrix (ECM) is one of the most important regulators of cellular and tissue function in the body. The ECM is known to play a critical role in driving cancer progression, and yet we lack knowledge of how ECM is altered during tumour progression to promote cancer metastasis. We have found that an enzyme secreted by tumor and stromal cells called lysyl oxidase (LOX) is responsible for altering the ECM at primary and metastatic sites to greatly enhance metastasis. LOX is an amine oxidase that catalyses the crosslinking of collagens and elastin in the ECM. LOX activity alters the structural and biochemical properties of the ECM, to drive cell proliferation, invasion and angiogenesis. Importantly, LOX modifies pre-metastatic tissue microenvironments prior to tumor cell arrival, enhancing metastatic colonisation and outgrowth. We are expanding our studies to further investigate how ECM is remodeled during cancer progression and how this impacts on cell behavior to drive metastasis.

Citation Format: Janine T. Erler. ECM remodeling at the pre-metastatic niche. [abstract]. In: Proceedings of the 107th Annual Meeting of the American Association for Cancer Research; 2016 Apr 16-20; New Orleans, LA. Philadelphia (PA): AACR; Cancer Res 2016;76(14 Suppl):Abstract nr SY44-02.
Mammalian Target of Rapamycin Signaling Pathway Changes with Intestinal Epithelial Cells Renewal Along Crypt-Villus Axis
Authors: Yang Huansheng , Xiong Xia , Wang Xiaocheng , Yin Yulong
Published: July 2016

Background/Aims: Understanding the mechanism that involves in regulating epithelial cells renewal is the fundamental of regulating intestinal mucosa development and functions and related diseases. The mechanistic target of rapamycin (mTOR) signaling pathway involves in controlling various major processes by integrating intracellular and extracellular cues. The present experiment was conducted to test the correlation between the mTOR signaling pathway and intestinal epithelial cells renewal along crypt-villus axis (CVA). Methods: Intestinal epithelial cells were sequentially isolated from the jejunum of piglets along CVA, and the amount or phosphorylation level of proteins involved in cell cycle, mTOR signaling pathway, gene expression, and the antioxidant capacity in the isolated cells were measured. Results: The results showed that the amount of proteins involved in cell cycle decreased from crypt to villus tip. The amount or phosphorylation level of proteins related to mTOR signaling pathway in intestinal epithelial cells mainly decreased during maturation along CVA. The amount of proteins involved in gene expression and the antioxidant capacity also decreased from crypt to the top of villi. Conclusions: These results indicate that the mTOR signaling pathway may be involved in regulating the intestinal epithelial cells renewal along CVA and it may partly through affecting the antioxidant capacity and gene expression of intestinal epithelial cells. Further histological verification is needed to confirm the results of the present experiments.
What Are the Optimal Monitoring Techniques in Head and Neck Microvascular Reconstruction?
Authors: Moubayed Sami P. , Mourad Moustafa , Urken Mark L.
Published: July 2016

Purpose: We evaluated the outcomes for widely used systems in terms of accuracy, salvage rates, and added cost compared to conventional monitoring. Methods: We performed a narrative review of the literature (high-impact report). Results: The overall free flap success for head and neck reconstruction is at least 95% using any type of monitoring. Salvage rates in decreasing frequency of monitoring techniques are 85% with near-infrared spectroscopy (NIRS), 81% with implantable Doppler, and 61.5% with conventional monitoring. False-positive rates in increasing frequency are 0% for NIRS, 0.4% for conventional monitoring, and <10% for implantable Doppler. Current data show implantable Doppler to be potentially cost-effective for institutions with a failure rate of at least 6%. Buried flaps may be monitored with conventional monitoring using an exteriorized paddle, or using implantable Doppler. Conclusions: The cost-effectiveness of advanced flap monitoring systems beyond conventional monitoring is related to the success rate of each institution. Cost-effectiveness studies are necessary to determine at what point NIRS becomes advantageous.
Intraductal Tubulopapillary Neoplasm of the Pancreas Masquerading as Pancreatic Neuroendocrine Carcinoma: Review of the Literature with a Case Report
Authors: Savant Deepika , Lee Lili , Das Kasturi
Published: July 2016

Background: Intraductal tubulopapillary neoplasm of the pancreas (ITPN) is a rare tumor which was first described in 2009. We report a case with cytologic and histologic findings and discuss the pitfalls in diagnosing this entity on cytology. Case: An 82-year-old female presented with a pancreatic body mass measuring 3.3 cm. Endoscopic ultrasound-guided fine-needle aspiration showed cells in cohesive clusters with high-grade nuclear atypia. Immunohistochemistry (IHC) showed the neoplastic cells to be positive for CK19, CD56 and chromogranin (focal). Ki-67 was high at 50-60%, and chymotrypsin was negative. On the basis of this pattern of staining, the cytologic diagnosis rendered was ‘favors high-grade neuroendocrine carcinoma'. Distal pancreatic resection revealed a cystic 4-cm mass. Histologically, the tumor was seen arising from the duct with a solid growth pattern, tubule formation and papillary structures. IHC showed the tumor to be negative for chromogranin, synaptophysin, CD56, trypsin and chymotrypsin. The Ki-67 index was 70%. The final diagnosis was noninvasive ITPN. Conclusion: We review the literature and discuss the cytomorphologic features and IHC patterns characteristic of this new entity on cytology material in addition to the pitfalls of the cytologic diagnosis.
A first note on foliicolous lichens of Assam, India
Authors: Gupta Pooja , Sinha G. P.
Published: July 2016

A first note on foliicolous lichens of Assam enumerating 26 species belonging to 15 genera and eight families are provided.  Four species viz., Bacidina apiahica, Byssoloma chlorinum, Calopadia fusca and Strigula nitidula are reported for the first time from Assam.  A number of rare species are present, including Aulaxina uniseptata, Calenia aspidota and Psorotheciopsis patellarioides.
Gentiana saginoides Burkill (Magnoliopsida: Gentianales: Gentianaceae) rediscovered from Sunderdhunga Valley in Uttarakhand 155 years after description: notes on its population status
Authors: Rawat Dharmendra S. , Rana Charan S. , Singh Harish , Karnatak Manish
Published: July 2016

Gentiana saginoides Burkill (Gentianaceae) was described by Burkill in 1906 based on a collection from Sunderdhunga, Uttarakhand by T. Anderson in 1857. The species was not collected after its type collection despite attempts by several workers in the past. A field survey in and around the type locality was conducted in June 2012 and the species was re-discovered after a lapse of 155 years since its type collection. The species is tentatively categorised as ‘Critically Endangered’ based on field observations. A full description and diagrams of the species are provided here based on new specimens collected.
Dialog und Heteroglossie im Faunus von Sibylla Schwarz
Authors: Bozzi Paola
Published: July 2016

In her pastoral work Faunus, Sibylla Schwarz reproduces the male discourse exactly, but with a female voice, which is, therefore, different and new. The author knows how to stylize different kinds of texts and tailor them to different speech acts. In the search for self-assurance and the suitable literary style, she stages a difficult dialogue of perspectives and voices. This paper investigates the extent to which her own and another’s voice interpenetrate, and the way in which meaning positions of speaker, addressee, and of what is discussed are expressed.
Mit spartanischer Stimme. Sibylla Schwarz und die Lyrik des Dreißigjährigen Kriegs
Authors: Hildebrandt Annika
Published: July 2016

Currently the focus within the study of war literature lies on experience. In contrast to this, Sibylla Schwarz’s “In Praise of Sensible and Virtuous Women” accentuates the interplay between poetical and historical discourses: in her translation of Heinsius, she adapts the speech of a Spartan woman in the mode of parenetical poetry. Read symptomatically, Schwarz’s approach highlights the generic conditions under which war poetry is produced. Simultaneously, it indicates the ambivalent status the genre achieves due to historical circumstances.
Die Lebenswelt der gelehrten Jungfrau aus der Greifswalder Stadtelite – ein Vergleich mit Breslau
Authors: Mróz-Jabłecka Kalina
Published: July 2016

From biographic information given in Protestant funeral sermons, one can obtain knowledge about the upbringing, education and status of women in the urban space. The following article attempts to describe from a micro-sociological perspective the lifeworld of Sibylla Schwarz, who died a premature death in 1638, as presented in Christoph Hagen’s sermon. Taking the aspect of the Querelle des Femmes into consideration, the article aims to compare the lifeworld of the poet to that of other learned women from Wrocław’s urban elite, as is described in selected funeral sermons from Silesia.
Referenzen der frühbarocken Dichtung von Sibylla Schwarz (1621–1638) auf die niederländische Literatur
Authors: Schneikart Monika
Published: July 2016

Followers of Martin Opitz like Hudemann, Rist, Köler, Plavius, Schneider and Sibylla Schwarz build their new poetics partly on the influence of Dutch literature. Schwarz’s adaptations of two poems from Daniel Heinsius’ Spiegel van de doorluchtige Vrouwen (1606) range between translatio and aemulatio. A further poem (“Nacht-Klage”) is compared to an adaptation before Opitz by Peter Lauremberg. Beginning in 1634 Schwarz found innovative ways of processing her knowledge of Jacob Cats’ marriage guide book, Houwelyck (1625), in poetic and pragmatic texts, so that the data by Ziefle need to be corrected. These documents of Dutch influence open up new perspectives on north-eastern Pomerania in the 1630s, especially with regard to the history of the book and the history of education.
Im Schnittpunkt. Sibylle Schwarzʼ Faunus und die Mischung der Diskurse
Authors: Kocher Ursula
Published: July 2016

Sibylle Schwarz’s pastoral, Faunus, is among those works of the Greifswald author that generally receive scant critical attention. The reason for this may lie in the fact, that some scholars perceive the text to be flawed and lacking in originality. A closer examination, however, reveals an aesthetic experiment on the principles of a traditional bucolic. The narrative combines different stylistic devices, genres and ways of representation. Furthermore, it can be seen as a reflection on writing, the status of the imaginary and even on literature itself. Sibylle Schwarz exploited the possibility of combining differing parts of the text offered by the bucolic, while at the same time making use of a fixed arsenal of topoi. The blending of diverse discourses enabled her to achieve a high degree of codification that turns a simple narration into a reflection on art and literature.
The Enculturation Experience of Three Chinese American Adolescents
Authors: Wang Sherry C. , Plano Clark Vicki L. , Scheel Michael J.
Published: July 2016

The authors designed a qualitative, multiple case study that employed the photovoice method to explore how enculturation is experienced by three Chinese adolescents living with their families in a nonethnically dense cultural community. A total of 18 one-on-one interviews were conducted with three youth and their parents. Photos were also used as elicitation tools to understand the meaning of enculturation for each individual. Case descriptions of each adolescent are presented, followed by five cross-case themes: (a) Self-Identifying as Chinese, (b) Parental Strictness, (c) Multiple Groups of Comparison, (d) (Not) Having a Chinese Community, and (e) Messages to Excel. The findings provide a descriptive understanding of how adolescent enculturation is shaped by the family, community, and their intersections. Implications for research and practice, such as the continued need to understand enculturation as a dynamic phenomenon and process, are presented.
Effect of Extraneous “Background” on Visualperceptual Performance of Readers and Non-Readers
Authors: Sabatino David A. , James E. Ysseldyke
Published: July 2016

Tests of visual-motor perceptual abilities, and especially the Bender Visual-motor Gestalt Test, ace heavily relied upon co establish diagnostic weaknesses that may relate to reading deficits in children. It was hypothesized that no significant difference would be observed between the performance of readers and non-readers on original or standard Bender designs and those designs modified by the addition of extraneous “background.” This study compared the performance of readers and non-readers on the standard Bender, a Bender memory test, and two Benders with stimulus designs on extraneous backgrounds.
Cognitive Capitalism
Authors: Coyle Thomas R. , Rindermann Heiner , Hancock Dale
Published: July 2016

Cognitive ability stimulates economic productivity. However, the effects of cognitive ability may be stronger in free and open economies, where competition rewards merit and achievement. To test this hypothesis, ability levels of intellectual classes (top 5%) and average classes (country averages) were estimated using international student assessments (Programme for International Student Assessment; Trends in International Mathematics and Science Study; and Progress in International Reading Literacy Study) ( N = 99 countries). The ability levels were correlated with indicators of economic freedom (Fraser Institute), scientific achievement (patent rates), innovation (Global Innovation Index), competitiveness (Global Competitiveness Index), and wealth (gross domestic product). Ability levels of intellectual and average classes strongly predicted all economic criteria. In addition, economic freedom moderated the effects of cognitive ability (for both classes), with stronger effects at higher levels of freedom. Effects were particularly robust for scientific achievements when the full range of freedom was analyzed. The results support cognitive capitalism theory: cognitive ability stimulates economic productivity, and its effects are enhanced by economic freedom.
Who Is Most Influenced by Justice Perceptions? Assessing the Role of Occupational Status
Authors: Potipiroon Wisanupong , Rubin Ellen V.
Published: July 2016

A growth in organizational justice research is evident in the field of public administration. This present study asks whether the relationship between key justice perceptions and attitudinal and performance outcomes vary as a function of occupational status. Building on the extant literature on social status, this study hypothesizes that employees in a higher status occupation will respond more strongly to justice perceptions than those in a lower status occupation by exhibiting lower levels of job satisfaction, organizational commitment, task performance, and citizenship behaviors. Based on a sample of employees in a large public agency in Thailand, our findings indicate that although employees in the two occupational groups do not differ significantly in their perceived justice levels, those in a higher status occupation are more strongly affected by perceptions of procedural and interpersonal justice. This study underscores the importance of accounting for occupational differences when it comes to implementing justice-related policies and practices.
Gendered Perceptions of Drugs, Aggression, and Violence
Authors: Helm Susana , Okamoto Scott K.
Published: July 2016

Drug use has been linked empirically with aggression and violence among youth in national and State of Hawai‘i samples. In addition, aggression and violence appear to be gendered experiences perceived differently by girls and boys. This article explores the intersection of drug offers/drug refusals with aggression and violence with specific attention paid to gendered perceptions of drug use situations as a context for aggression and violence. A qualitative study, in which 14 sex-specific focus group discussions were held, focused on rural Native Hawaiian middle school students ( N = 64). Students were asked to discuss drug refusal strategies in a variety of drug offer contexts. Feminist theories and approaches were used to examine the role of aggression and violence in drug refusal as perceived by Native Hawaiian girls as compared with boys. Girls and boys differed in their perceptions of aggression and violence in drug offer situations, initially as evidenced by the extent to which the girl groups focused on the intersection of drugs and violence. Furthermore, qualitative analyses reflected gender norms and stereotypes about aggression and violence perpetration, and girls’ apparently unique concerns about sexual violence victimization. Implications are discussed in terms of prevention research and practice, specifically in terms of school-based prevention curricula.
Perceptions About Sexual Offenses: Misconceptions, Punitiveness, and Public Sentiment
Authors: King Laura L.
Published: July 2016

Decades of research on public opinion about crime reveal varying, yet relatively punitive attitudes that are often riddled with misconceptions. Sparked by the increased media and legislative attention devoted to sex offenders beginning in the 1990s, researchers began to more closely examine public opinion about sexual offenses. Findings suggest the public adheres to several misconceptions about sexual offenses and supports harsh sanctions for offenders. However, further research is warranted to more closely examine the relationships among these variables. Thus, the goal of the present study was to survey Pennsylvania residents to examine the degree to which misconceptions about sexual offenses inform punitiveness. The results supported the hypotheses in that a high level of support for misconceptions and punitiveness was identified, and adherence to misconceptions was the strongest predictor of punitiveness. These findings demonstrate a clear need for educational and awareness efforts to dispel public misconceptions about sexual offending and victimization.
Deltaic land subsidence and sea level fluctuations along the east coast of India since 8 ka: A palynological study
Authors: Farooqui Anjum , Ranjana  , Nautiyal Chandra Mohan
Published: July 2016

The consequences of climate change and land subsidence are often related to sea level rise/fall. Mangrove extinction and migration were assessed through palynological studies in two sedimentary cores in order to address climate, Relative Sea level (RSL) and its relation to geomorphology since 8420 cal. yr BP from Kanuru (500 cm deep) and since 5850 cal. yr BP from Machilipatnam (118 cm deep), Krishna delta, India. Four units/nine phases of sediment depositional environment were identified on the basis of marine/terrestrial palynomorphs. In Unit 1, the marine palynomorphs indicate palaeoshoreline in Kanuru from 8420 to 8300 cal. yr BP which is now ~4–5 km from the present-day shoreline, but after a short span a retreat in sea level took place between 8300 and 7040 cal. yr BP. About three to four short-term intermittent rise/fall in RSL were recorded in Unit 2 between 7040 and 3980 cal. yr BP in Kanuru and between 5225 and 3240 cal. yr BP in Machilipatnam. During this period, the diversity of mangroves was more in Machilipatnam and only salt-tolerant mangroves were present in Kanuru. Unit 3 is characterized by non-estuarine sediment deposition since 3920–240 cal. yr BP in Kanuru and since 3240–950 cal. yr BP in Machilipatnam. Unit 4 shows a rise in RSL in both the studied sites which began much earlier in Machilipatnam than in Kanuru. Loss of mangrove diversity and dominance of salt-tolerant mangroves were recorded in Unit 4. Results indicate climate-induced RSL fluctuations highlighting the cooling event of 8.2 ka BP from Kanuru site and duration of intermittent rise/fall of RSL during middle Holocene transgression. The rate of sea level rise during the period was not continuous but interrupted by three to four retreats. At present, the evidence of these are at different depths in both the sites and in other contemporary sites along the east coast of India, suggesting neo-tectonics in the vertical stack of Holocene sediment. The geomorphology of the studied sector is tectonically controlled which may increase deltaic instability in future.
Biomarkers, lactate, and clinical scores as outcome predictors in systemic poisons exposures
Authors: Lionte C , Sorodoc V , Tuchilus C , Cimpoiesu D , Jaba E
Published: July 2016

Acute exposure to systemic poisons represents an important challenge in clinical toxicology. We aimed to analyze the potential role of cardiac biomarkers, routine laboratory tests, and clinical scores as morbidity and in-hospital mortality predictors in patients intoxicated with various systemic poisons. We conducted a prospective study on adults acutely exposed to systemic poisons. We determined the PSS, Glasgow Coma Scale (GCS), and we performed electrocardiogram, laboratory tests, lactate and cardiac biomarkers (which were reassessed 4 h, respectively 6 h later). Of 120 patients included, 45% developed complications, 19.2% had a poor outcome, and 5% died. Multivariate logistic regression sustained lactate (odds ratio (OR) 1.58; confidence interval (CI) 95%: 0.97–2.59; p 0.066), MB isoenzyme of creatine kinase (6h-CKMB; OR 1.08; CI 95%: 1.02–1.16; p 0.018) as predictors for a poor outcome. A GCS < 10 (OR 0.113; CI 95%: 0.019–0.658; p 0.015) and 4h-lactate (OR 4.87; CI 95%: 0.79–29.82; p 0.087) predicted mortality after systemic poisons exposure. Receiver operating characteristic analysis showed that brain natriuretic peptide (area under the curve (AUC), 0.96; CI 95%: 0.92–0.99; p < 0.001), lactate (AUC, 0.91; CI 95%: 0.85–0.97; p < 0.001), and 6h-CKMB have good discriminatory capacity for predicting a poor outcome. In conclusion, these biomarkers, lactate, and GCS can be used to predict morbidity and mortality after systemic poisons exposure.
Neuropsychiatric manifestations of Parkinson’s disease
Authors: Molina Ruiz Rosa M , Evans Andrew H , Velakoulis Dennis , Looi Jeffrey CL
Published: July 2016

Objective:

This clinical update review focuses on the classification and description of common neuropsychiatric manifestations in Parkinson’s disease (PD).

Method:

We conducted a systematic search of the literature using Pubmed and selected the most recent and relevant papers for this review.

Results:

Neuropsychiatric manifestations in PD are are very frequent and may arise from an abnormal psychopathological response to the disease, neurobiological changes related to the disease itself, complications of treatments or a combination of all of these.

Conclusions:

Neuropsychiatric symptoms may precede the motor clinical presentation of PD. Early recognition is essential.
Nonlinear control of stick-slip oscillations by normal force modulation
Authors: Nath Jyayasi , Chatterjee S
Published: July 2016

The present paper investigates the efficacy of controlling friction induced vibration by normal load modulation. Friction-induced self-excited vibration, attributed to the low-velocity drooping characteristics of friction (Stribeck effect), is modelled by a mass-on-belt model where the normal force of the mass is being modulated based on the acceleration feedback followed by a second order filtering. Polynomial model is employed to study the friction phenomenon between the mass and the belt. The pole crossover design (to ensure faster transient and greater relative stability) is implemented to optimize the filter parameters with an independent choice of the belt velocity and control gain. These sets of optimized parameter values are then used to construct local stability boundaries in the plane of control parameters. Numerical simulations in a MATLAB SIMULINK model and bifurcation diagrams obtained in AUTO (while using belt velocity as the bifurcation parameter) indicate that a significantly small-amplitude limit cycle resulting from a supercritical Hopf bifurcation stabilizes the extreme low velocity region at higher values of the control gain. With the increase of the control gain the subcritical nature of Hopf bifurcation changes to a supercritical one. The efficacy of this optimization (based on numerical results) in the delicate low velocity region is also enclosed.
A criterion for optimal sensor placement for minimizing spillover effects on optimal controllers
Authors: Khushnood Muhammad Atif , Xiaogang Wang , Naigang Cui
Published: July 2016

Optimal control techniques (LQG, H∞, etc.) offer several advantages for active vibration control, such as possibility of trade-off between achievable vibration attenuation and required control inputs, simultaneous suppression of multiple modes, unified and systematic controller design procedure for MIMO systems. However, a major limitation in their application has been the phenomena of spillover. For optimal controllers robustness to spillover is achieved by rolling-off controller response. In this paper, a novel criterion of sensors placement to minimize roll-off requirement, for given actuator locations, is proposed. As an illustration H∞ control is applied for suppressing first two modes of a slewing spacecraft. Comparison of results obtained for sensor location based on proposed criterion with those of collocated sensor location showed: (a) for a given controller order, performance characteristics similar to collocated control with improved robustness to spillover can be obtained by using the proposed criterion of sensor placement; (b) with proposed placement criterion robustness to spillover can be maintained with lower order controller as compared with the minimum controller order required for collocated control.
Depression and anxiety in patients receiving interferon-alpha: The role of illness perceptions
Authors: Hepgul Nilay , Pariante Carmine M , Baraldi Sara , Borsini Alessandra , Bufalino Chiara , Russell Alice , Agarwal Kosh , Cleare Anthony J , Forton Daniel M , Henderson Max , Mondelli Valeria , Ranjith Gopinath , Hotopf Matthew
Published: July 2016

Development of psychiatric symptoms during interferon-alpha therapy may be influenced by psychological factors. We examined illness perceptions using the Revised Illness Perceptions Questionnaire in 55 patients with chronic hepatitis C virus infection, due to receive interferon-alpha. The Hospital Anxiety and Depression Scale was used to assess the development of symptoms. Negative identity, consequences and emotional representation beliefs were significantly associated with both higher depression and anxiety scores. Negative illness perceptions play a predictive role in the development of interferon-alpha-induced psychiatric symptoms.
When childbirth becomes a tragedy: What is the role of hospital organization?
Authors: Cipolletta Sabrina
Published: July 2016

In this autoethnographic study, I analyse my birthing event, in order to point out some relevant cultural aspects of the experience. I explore the role of expectations, childbirth place, medicalization and relationships with healthcare professionals and partner. My experience and the analysis of the context where childbirth takes place leads to the conclusion that hospital organization is central to women’s experiences of giving birth, but the hospital culture is still too centred on the security that medical interventions guarantee, relegating people to a passive position. Health services should address personal agency, in order to guarantee more respectful childbirth care.
Multimodality treatment of brain metastases from renal cell carcinoma in the era of targeted therapy
Authors: Bassanelli Maria , Viterbo Antonella , Roberto Michela , Giacinti Silvana , Staddon Anita , Aschelter Anna Maria , D’Antonio Chiara , Marchetti Paolo
Published: July 2016

In patients with renal cancer, brain metastasis is associated with poor survival and high morbidity. Poor life expectancy is often associated with widespread extracranial metastases. In such patients, a multidisciplinary approach is paramount. Brain metastases-specific therapies may include surgery, radiosurgery, conventional radiation and targeted therapies (TT) or a combination of these treatments. Some factors are important prognostically when choosing the best strategy: performance status, the number, size and location of brain metastases, the extension of systemic metastases and a well-controlled primary tumour. Failure of chemical therapy has always been attributed to an intact blood–brain barrier and acquired drug resistance by renal cancer cells. Recent studies have demonstrated objective responses with TT in a variety of cancer types, including renal cancer. In most cases, these agents have been used in combination and in conjunction with whole-brain radiation therapy and radiosurgery. Local control appears to be better with the combined method if the patient has a good performance status and may improve overall survival. This review summarizes current literature data on multidisciplinary approach in the management of renal brain metastasis with radiation, surgery and TT with an emphasis on potential better outcomes with a combination of current treatment methods.
Ergonomics and Prevention of Injuries From Needles Sticks and Sharps in the OR
Authors: Kalaga Pramila , Balters Marcus , Crowley Lynn , Paulsen Lisa , Erkes Laura Peet , Boes Emily , Patterson Emalee , Carr Jill , Forse Armour , Alsagar Barb , Culbertson Sandy , Kayl Matt , Jessen Christopher , Wright Christine , Myers Janel
Published: July 2016

Aim:

Implement ergonomic process improvement within the OR, to decrease incidence of injuries from sharps and needle sticks among the OR teams.

Method:

A pre and post intervention design was adopted. The number of reported incidents related to needle sticks and sharps over a seven month period prior to the implementation of the ergonomic process improvement(January to July 2014) and over a seven month period following implementation(January to July 2015), were compared. A participatory approach was adopted, for conducting the study and the study team included an ergonomist, surgery educators, two surgeons, operations leader, department manager, team lead, risk manager and two pre-med students functioning as study assistants. Ergonomics training for the prevention of injuries from sharps and needle sticks was developed, which incorporated physical, cognitive and teamwork measures alongside the prevention measures outlined by AORN and evidence based measures identified following a literature review. The Surgery Educator, the Ergonomist and an Attending Surgeon, participated in delivering the ergonomics injury prevention training. The management, including the Team Lead and OR Manager participated in supporting and facilitating the implementation of the injury prevention measures, where possible, such as double gloving; safe passing zones; verbal feedback; silence or task related communications only during critical phases, etc.

Results:

A significant difference was found in the frequency of the overall sharps and needle stick related incidents over the pre and post implementation time periods of interest(Wilcoxon Signed Rank test - significant at p≤ 0.05 level, where the W-value is 2 and the critical value for W with N=6 is 2). 63.51% decrease in incidence rate was found among the OR staff, and 44.25% decrease in incidence rate was found among students and residents, pre and post implementation. Overall, a 55% decrease was found in the incident rate of events related to sharps and needle sticks among the OR teams(experts and novices combined), over the first seven months of implementing the ergonomic process improvement.

Conclusion

Within the complex task and team work environments of the operating room in teaching hospitals, ergonomics and human factors fundamentals related to individual task performance, team work and work design could help improve the effectiveness of the safety measures.
Endogenous Estrogen Regulates Somatostatin-Induced Rebound GH Secretion in Postmenopausal Women
Authors: Veldhuis Johannes D. , Erickson Dana , Yang Rebecca , Takahashi Paul , Bowers Cyril
Published: July 2016

Background:

Systemic concentrations of T, estradiol (E2), GH, IGF-1, and IGF binding protein-3 decline in healthy aging individuals. Conversely, T and E2 stimulate GH and IGF-1 production in hypogonadal patients.

Hypothesis:

Because E2 stimulates GH secretion, putatively via the nuclear estrogen receptor-α and E2 and GH fall with menopause, we postulated that diminished endogenous E2 contributes to low GH output in older women.

Location:

The study was conducted at the Mayo Center for Clinical and Translational Science.

Study Design:

This was a randomized, double-blind, controlled study in 60 healthy postmenopausal women treated with the following: 1) double placebo; 2) anastrozole, a potent inhibitor of aromatase-enzyme activity, which mediates E2 synthesis from T; and/or 3) fulvestrant, a selective estrogen receptor-α antagonist.

Methods:

GH pulse generation was quantified by frequent GH sampling before and after short-term iv somatostatin infusion, thought to induce hypothalamic GHRH-mediated rebound-like GH secretion.

Results:

On anastrozole, E2 fell from 3.1 ± 0.35 pg/mL to 0.36 ± 0.04 pg/mL, and estrone from 13 ± 1.4 pg/mL to 1.9 ± 0.01 pg/mL (P < .001) by mass spectrometry. Estrogen values were unchanged by fulvestrant. T concentrations did not change. One-hour peak GH rebound after somatostatin infusion declined markedly during both estrogen-deprivation schedules (P < .001). Mean (150 min) maximal GH rebound decreased comparably (P < .001). Measures of GH rebound correlated negatively with computed tomography-estimated abdominal visceral fat (all P < .05).

Conclusion:

These data suggest a previously unrecognized dependence of hypothalamo-pituitary GH regulation on low levels of endogenous estrogen after menopause.
Rediscovering The Roses of Eyam: A forgotten television play
Authors: Lamb Ben
Published: July 2016

In 1973 playwright and television dramatist Don Taylor rewrote and directed his play The Roses of Eyam for UK television. The original play, which was staged at the Northcott Theatre in Exeter in 1970, has been somewhat disregarded in Theatre Studies criticism despite its worldwide popularity in educational circles. Similarly, the subsequent television play has been relatively overlooked in historical studies of British television despite the fact it was one of the most ambitious dramas of its time. This article examines Don Taylor’s 1973 televisual adaptation in relation to his original production through archival research of production documents, interviews with producer David Rose, and a number of textual analyses. Analysing the process of adaptation the play had to undergo to fit with the conventions of 1970s studio productions will reassess established truisms present within adaptation scholarship regarding the visual language of studio-based television drama.
Review
Authors: Raw Laurence
Published: July 2016

DASHIELL HAMMETT AND THE MOVIES, WILLIAM H. MOONEY (2014) New Brunswick: Rutgers University Press, 213 pp., ISBN: 9780813562620, p/bk, $26.95
Practitioners’ Perspectives
Authors: Ue Tom , Shinn Christopher
Published: July 2016

The following interview was completed by e-mail on 26 November 2015. It focuses on Christopher Shinn’s Teddy Ferrara (2015), a play both informed by and in response to a number of recent suicides, including that of Tyler Clementi. This conversation explores Shinn’s creative processes for the play, which began its theatrical life in the Goodman Theatre in Chicago before being brought to the Donmar Warehouse in London where it had its London premiere. It goes on to examine Shinn’s views about the adolescent experience, desire, and LGBTQ issues, and it suggests some avenues for more positive ways to engage in discussions despite our differences.
Aplicação do método COP para avaliação da vulnerabilidade intrínseca à contaminação do aquífero cárstico Salitre, Irecê-BA, Brasil.
Authors: Villanueva Tereza Cristina Bittencourt , Bastos Leal Luiz Rogério , Zucchi Maria do Rosário , Azevedo Antônio Expedito Gomes de , Villanueva Pablo Ramosandrade
Published: July 2016

A área de estudo localiza-se na microrregião de Irecê, situada na porção centro-norte do estado da Bahia, Brasil. Compreende uma área piloto do aquífero cárstico Salitre, de aproximadamente 250km², delimitada por parte dos municípios de Irecê e Lapão. Constitui-se por rochas carbonáticas da Formação Salitre de idade Neoproterozóica. Para determinação da vulnerabilidade intrínseca à contaminação do aquífero na área foi utilizado o Método COP, e para tanto, alguns produtos foram gerados para aplicação no modelamento, como análise granulométrica dos solos, elaboração do Mapa Hidrogeológico, Mapa de Declividade, Mapa de Dolinas e Fraturas e Mapa de Uso e Ocupação dos Solos, em escala 1:25.000. Esses produtos permitiram a geração do Mapa de Vulnerabilidade Intrínseca à Contaminação da área, que apresentou como resultado um zoneamento de vulnerabilidade que possibilitou a delimitação de 3 classes de vulnerabilidade intrínsecas na área: Moderada (53%), Baixa (40%) e Muito Alta (7%). Os resultados obtidos podem ser utilizados para o planejamento, gestão hídrica e territorial da área.
Direct georeferencing with correction of map projection distortions for active imaging
Authors: Švec Zdeněk
Published: July 2016

In aerial photogrammetry, the Cartesian coordinate system for the description of object space is commonly used. In contrast, many projects have to be processed in the space combined by the composition of a map projection and Vertical datum. In that space, some geometric deformations exist. There are some compensative methods for active and passive sensors. In the case of active sensors, decomposition and the correction of observation vector for each ground point can be used. We obtain height, horizontal distance and horizontal angle in this process. All of these values should be corrected for precise georeferencing. The contribution deals with the derivation of the corrections and gets some theoretical values from the area of the Czech Republic.
Multiple query optimization on the D-Wave 2X adiabatic quantum computer
Authors: Trummer Immanuel , Koch Christoph
Published: July 2016

The D-Wave adiabatic quantum annealer solves hard combinatorial optimization problems leveraging quantum physics. The newest version features over 1000 qubits and was released in August 2015. We were given access to such a machine, currently hosted at NASA Ames Research Center in California, to explore the potential for hard optimization problems that arise in the context of databases.

In this paper, we tackle the problem of multiple query optimization (MQO). We show how an MQO problem instance can be transformed into a mathematical formula that complies with the restrictive input format accepted by the quantum annealer. This formula is translated into weights on and between qubits such that the configuration minimizing the input formula can be found via a process called adiabatic quantum annealing. We analyze the asymptotic growth rate of the number of required qubits in the MQO problem dimensions as the number of qubits is currently the main factor restricting applicability. We experimentally compare the performance of the quantum annealer against other MQO algorithms executed on a traditional computer. While the problem sizes that can be treated are currently limited, we already find a class of problem instances where the quantum annealer is three orders of magnitude faster than other approaches.
Risk Management Model in Surface Exploitation of Mineral Deposits
Authors: Stojanović Cvjetko
Published: July 2016

Risk management is an integrative part of all types of project management. One of the main tasks of pre-investment studies and other project documentation is the tendency to protect investment projects as much as possible against investment risks. Therefore, the provision and regulation of risk information ensure the identification of the probability of the emergence of adverse events, their forms, causes and consequences, and provides a timely measures of protection against risks. This means that risk management involves a set of management methods and techniques used to reduce the possibility of realizing the adverse events and consequences and thus increase the possibilities of achieving the planned results with minimal losses.

Investment in mining projects are of capital importance because they are very complex projects, therefore being very risky, because of the influence of internal and external factors and limitations arising from the socio-economic environment. Due to the lack of a risk management system, numerous organizations worldwide have suffered significant financial losses. Therefore, it is necessary for any organization to establish a risk management system as a structural element of system management system as a whole.

This paper presents an approach to a Risk management model in the project of opening a surface coal mine, developed based on studies of extensive scientific literature and personal experiences of the author, and which, with certain modifications, may find use for any investment project, both in the mining industry as well as in investment projects in other areas.
Introducing Au Potential Areas, Using Remote Sensing and Geochemical Data Processing Using Fractal Methods in Chartagh, Western Azerbijan – Iran
Authors: Mansouri Edris , Feizi Faranak
Published: July 2016

The studied area - Chartagh - is located in the East of Azerbaijan gharbi Province, Iran. In this paper, geology map, ASTER satellite images were used and after processing these images with ENVI softwares, geochemical data analysis consisting of lithogeochemical samples, within geological field observations. On ASTER data; using a number of selected methods including band ratio, Minimum Noise Fraction (MNF) and Spectral Angle Maper (SAM) distinguished alternation zones. Geochemical anomalies were separated by number - size (N-S) fractal method. (N-S) fractal method was utilized for High intensive Au, As and Ag anomalies.
Analysis of Combustion Process of Sewage Sludge in Reference to Coals and Biomass
Authors: Środa Katarzyna , Kijo-Kleczkowska Agnieszka
Published: July 2016

Production of sewage sludge is an inseparable part of the treatment process. The chemical and sanitary composition of sewage sludge flowing into the treatment plant is a very important factor determining the further use of the final product obtained in these plants. The sewage sludge is characterized by heterogeneity and multi-components properties, because they have characteristics of the classical and fertilizer wastes and energetic fuels. The thermal utilization of sewage sludge is necessary due to the unfavorable sanitary characteristics and the addition of the industrial sewage. This method ensures use of sewage sludge energy and return of expenditure incurred for the treatment of these wastes and their disposal. Sewage sludge should be analyzed in relation to conventional fuels (coals and biomass). They must comply with the applicable requirements, for example by an appropriate degree of dehydration, which guarantee the stable and efficient combustion.

This paper takes the issue of the combustion process of the different sewage sludge and their comparison of the coal and biomass fuels.
Arsenic Pollution Study at Nitra-Krška Ny Location as an Example of Line Contamination
Authors: Varga Michal , Kolenčík Marek
Published: July 2016

The aim of this article was to identify the level of arsenic in soils and water as a type of line contamination with widespread environmental impact. For this purpose, as the “model locality” was chosen the Nitra River (Krškany location situated around 80 km from the original source of contamination - Zemianske Kostoľany). EcaFlow 150 analyzer was used to identify the content of arsenic in water and soil samples, SEM and EDS were used to characterize morphology, surface area, and chemical composition of primary substrate. In Nitra-Krškany, significant values of arsenic concentrations were observed for surface water, 14.75 μg l-1, which exceeded the WHO international A limit 1.5 times, for filtered water from the sediment, 149.9 μg l-1, with the present exceedance in all categories (WHO international A limit 15 times), and for soil samples, 26.6 mg kg-1, which exceeded 2.6 times the Slovak soil legal limit (10 mg kg-1). Detection of arsenic confirmed line contamination in Nitra - Krškany. As the main source responsible for contamination there was evaluated coal combustion residuals that consist of spherical aggregates from 2 μm to 1 mm dimension, non-linear topography. This type of contamination has a long-term impact due to hazardous materials and non-stable reactive surface area.
Medical Informatics applied in psoriasis diagnosis and management
Authors: Hangan L.T. , Capatana D. , Nicola Gh. , Chirila S. , Gurgas L. , Cambrea Simona Claudia
Published: July 2016

Psoriasis represents a chronic disease, with a prevalence of 0.91% to 8.5% worldwide. The clinical manifestations of the disease vary a lot from patient to patient and the response to treatment also varies a lot.

Today, in spite of the drawbacks it has, PASI (Psoriasis Area Severity Index) represents one of the best tools used to evaluate the extent of the disease and the response to medication.

One of the drawbacks of using this scoring system is considered to be the way a doctor has to calculate the result. In this study we offer, step by step, a possible solution to create an informatics tool that can offer the result of the score based on the inputs made by the doctor.
Escalation of tuberculosis notification: an analysis of associated social factors
Authors: Miandad Muhammad , Nawaz-ul-Huda Syed , Burke Farkhunda , Azam Muhammad , Khan Imran
Published: July 2016

Studies have revealed that socioeconomic factors such as those pertaining to unmarried respondents, dependency, housing congestion and room sharing are associated with tuberculosis rates not only in developing countries but also in developed countries. Karachi has been identified as one of the most vulnerable cities where the spread of TB is increasing with the passage of time. The purpose of the present study is to assess TB notification with reference to some social factors in order that the findings of this study may provide helpful information for guidance related to social and economic policy formulation, at least at the local level to combat and eliminate tuberculosis. The methodology was based on NTP registered patients’ data and social factor analysis data which were acquired through questionnaire survey from notified patients. The result pertaining to TB notification reveals an increasing trend during the last seven years from 2007 until 2013. The notification of female patients compared to that of males is high, which is evidence of the fact that women in Pakistan are more affected but a comparison of patients to the total population in the respective years i.e. the patient population ratio, reveals a decreasing trend. The findings of the study emphasize that the problem of TB control can be resolved expeditiously with the cooperation of the public sector, which should be motivated to meet the core requirements of the programme at various administrative levels and strongly enforced standards of quality of life.