bluuebunny/crossref_metadata_2025 huggingface dataset:
Air Conditioning
Authors:   School Of Mechanical Engineering, Lingaya’s Vidyapeeth, Faridabad, Haryana, Kumar, Mr. Lokesh
Published: April 2024

The working principles and the basic features of air conditioning systems are introduced in this paper. With the improvement of standard of living, air-conditioning has widely been applied. The increasing demand for comfort air-conditioning has brought within the need for greater numbers of practical, technical and sales personal who have should training in basics principles and applications of modern air-conditioning. The technical information presented in this work is intended to satisfy the immediate and fundamental concepts and relevant principles in the field of air-conditioning. The subject of air-conditioning has come to stay with the universities in the country. Keywords: Air-conditioning, Technology, Cooling system
Detection of Fake Currency Using Machine Learning
Authors:   Assistant Professor, Department of Computer Science and Engineering, Tirumala Engineering College, Teja Mr. Y. Vamsi Krishna
Published: April 2024

Counterfeiting of currency is a growing problem due to advancements in color printing technology, impacting economies worldwide. Fake money is often used for criminal activities, including terrorism. Research indicates that developing countries, like India, are particularly affected. One solution proposed involves analyzing the image of counterfeit currency through pre-processing steps such as converting from RGB to grayscale. This approach aims to tackle the issue of counterfeit currency circulation effectively. After converting the text, the image is divided into sections, its characteristics are assessed, relationships are identified, and a decision is made to determine if the image is authentic or counterfeit. Counterfeit currency continues to be a notable problem. Financial institutions and other establishments have the necessary resources to confirm the legitimacy of money. However, the average person does not have access to such equipment, making it essential to have counterfeit money detection software that can be used by anyone. This study achieves a maximum accuracy of 81% when analyzing 50 Indian currency notes with a denomination of 2000 rupees. This initiative offers a comprehensive overview of a counterfeit detection system that is accessible to the general public. The proposed system uses image processing to distinguish real currency from counterfeit money. The entire software has been developed using the Python programming language. Key Words: Fake Currency, Counterfeit, Denomination, Python, Machine Learning,
Maximum Power Point Tracking with Artificial Neural Network
Authors:   UG students, Department of Electrical and Electronics Engineering, Sai Rajeswari Institute of Technology,, L . Shreya
Published: April 2024

The urgent depletion of fossil fuel resources and the pressing need for environmental preservation have spurred a critical examination of alternative energy solutions. In response, this study focuses on the development of innovative approaches to mitigate the overreliance on conventional energy sources and transition towards sustainable alternatives. As part of a final year project, the research draws inspiration from this imperative and endeavors to design a prototype model that integrates advanced techniques for harnessing solar energy. Index Terms–Maximum Power Point, Buck-Boost Converter, Neural Network Architecture
GENERATIONAL INVESTMENT PATTERNS IN MUTUAL FUNDS: A COMPARATIVE STUDY OF GENERATION X AND MILLENNIALS
Authors:   Master of Business Administration,  Sathyabama University, Chennai, KUMAR ABHISHEK
Published: April 2024

This Master’s thesis examines the investment patterns in mutual funds across two distinct generational cohorts: Generation X and Millennials. The primary aim of this study is to analyze and compare the investment behaviors and preferences between these two groups, focusing on factors such as risk tolerance, investment time horizon, and preferred fund types. Utilizing a mixed-methods approach that combines quantitative data analysis of investment portfolios with qualitative surveys and interviews, this research provides a comprehensive view of how generational differences influence investment decisions. The quantitative analysis involves a statistical examination of mutual fund holdings and transactions sourced from a proprietary database covering the period from 2010 to 2020. Meanwhile, the qualitative component features insights from over 200 individual interviews with representatives of each generation, supplemented by surveys to gauge attitudes towards various investment strategies and market outlooks. Initial findings suggest significant divergences in the investment strategies between Generation X and Millennials. Generation X investors tend to favor income-focused and balanced funds, displaying a preference for stability and long-term growth, influenced possibly by their proximity to retirement. In contrast, Millennials are more inclined towards equity-heavy portfolios and show a greater propensity for embracing emerging market funds and ESG (environmental, social, and governance) themed investments, driven by higher risk tolerance and a longer investment horizon. This thesis not only highlights the distinct investment preferences of these generations but also delves into the sociopolitical and economic factors that might influence these patterns. Furthermore, it discusses the implications of these generational differences for financial advisors, mutual fund managers, and policymakers. By identifying and understanding these generational investment behaviors, industry professionals can better tailor their approaches to meet the needs and preferences of each demographic group, enhancing client satisfaction and engagement. This comparative study contributes to the financial industry’s understanding of demographic shifts and their impacts on market trends, offering valuable insights for developing more targeted and effective investment products and strategies.
International Laws and their Implications for Sustainable Growth
Authors:   BA HONS. BUSINESS ECONOMICS AMITY SCHOOL OF ECONOMICS, AUUP, Nihalani Mehak
Published: April 2024

This paper sheds light on how international laws embrace global sustainability goals. Sustainable development has become a focal point in numerous international treaties and conventions, featuring in over 300 agreements, both binding and non-binding. It's widely acknowledged that environmental laws, intertwined with social and economic factors, lay the groundwork for sustainable development objectives, potentially guiding judicial decisions. There's evidence suggesting that international judicial bodies have considered sustainability considerations in their rulings. Furthermore, the paper delves into strategies for tailoring these objectives to fit regional and local contexts, drawing insights from the practices of neighboring countries. This approach seeks to deepen our understanding of how to effectively integrate sustainability goals across various levels of governance.
The Effect of Integrated Warehouse Operation Efficiency on Organizations Performance
Authors:   SOC, NMIMS (Deemed to be University), Navi Mumbai., Bhatia, Maahir
Published: April 2024

In the contemporary business landscape, warehouse efficiency has emerged as a cornerstone of organizational prowess, serving both as a centre of expertise and a strategic tool for competitive advantage. A well-functioning warehouse not only facilitates swift fulfilment of customer needs but also significantly enhances overall business performance. This study seeks to investigate the impact of warehouse attributes on efficiency, focusing particularly on layout and operations. Through a comprehensive literature review, we explore the role of warehouse design and operational practices in driving efficiency gains. Our analysis reveals that the configuration of a warehouse plays a pivotal role in determining its operational effectiveness, with optimized layouts facilitating rapid response to customer demands. Furthermore, effective warehouse operations are identified as critical components in enhancing overall efficiency, working synergistically with layout design to bolster performance. Concurrently, inventory management has emerged as a paramount concern for organizations worldwide, directly influencing operational success. Efficient inventory practices not only enhance customer service but also mitigate stock-related challenges.. By synthesizing insights from both warehouse efficiency and inventory management domains, this study aims to provide a comprehensive understanding of the strategies employed by organizations to optimize operational performance and drive sustainable growth. Keywords: Seamless integration of inventory practices, Efficient warehouse operations, Technological advancements in inventory control, Inventory tracking systems, Optimization of holding costs Technology-driven warehouse management
BRIDGING THE RURAL DIVIDE: UNRAVELING DISTRIBUTION CHALLENGES AND INNOVATING SOLUTION IN EMERGING MARKET
Authors:   School of Business Galgotias University, Singh, Kshitiz
Published: April 2024

This thesis investigates the distribution challenges currently in pastoral areas of Jharkhand and Odisha, two states in India characterized by significant rural populations and diverse socio-economic geographies. The digital peak between civic and pastoral areas has been a persistent barrier to economic development in rising requests like India. Through a mixed-system approach encompassing qualitative interviews and quantitative analysis, this study aims to interpret the factors contributing to the rural-urban divide and explore innovative solutions to ameliorate distribution networks. The literature review synthesizes existing research on rural distribution challenges, the digital divide, and innovative solutions worldwide, furnishing a theoretical framework for the study. Detailed case studies of select rural areas in Jharkhand and Odisha exfoliate light on specific distribution challenges faced by local businesses and consumers, examining the part of the structure, technology relinquishment, request dynamics, and government programs. Drawing perceptivity from stakeholder interviews and case studies, this thesis proposes innovative results acclimatized to the unique requirements of pastoral communities in Jharkhand and Odisha. These results encompass using technology, enhancing last-afar connectivity, perfecting logistics structure, and fostering entrepreneurship. The impact assessment evaluates the effectiveness of the enforced results in bridging the pastoral-civic peak and fostering profitable development. crucial performance pointers such as access to goods and services, income generation, and overall community development are anatomized to gauge the issues. In conclusion, this study underscores the significance of addressing distribution challenges in pastoral areas for inclusive growth and sustainable development in arising requests. Recommendations are handed to policymakers, businesses, and other stakeholders to further strengthen pastoral distribution networks and promote indifferent access to openings in Jharkhand, Odisha, and beyond.
A Study on an Impact of Talent Acquisition and Recruitment through Social Media
Authors:   Master Of Business Administration  School of Business ,Galgotias University, Gudiya Saloni
Published: April 2024

Social media is essential to modern recruiting, particularly when it comes to corporate branding. 76 percent of businesses, according to Employer Branding International, use social media to develop and market their employer brands. In an effort to attract candidates who will fit in as employees, businesses strategically use social media to advertise their cultures, values, and beliefs. However, for effective employer brand promotion, the business must have an identity that is real, credible, relevant, distinctive, and aspirational in order to draw in both present and potential employees. Recruiters can engage job seekers and establish two-way conversation via social networking platforms. Social media is a desirable recruiting tool due to the appeal of decreased expenses for businesses. But little is known about how job prospects use social media during the application process or their capacity to research available positions. In the proposed study, job seekers will be surveyed in order to gauge their perceptions of employer brands, corporate websites, and applicant appeal. Additionally, it will research how dedicated job applicants anticipate being to the business once hired in order to discover, acquire, evaluate, and hire prospects to fill positions necessary to achieve project objectives and company goals.
DIET PLANNING AND RECOMMENDATION SYSTEM USING ML AND MERN STACK
Authors:   Assistant Professor, Computer Science and Engineering, Raghu Engineering College, Visakhapatnam, Uma Pyla.
Published: April 2024

The "Diet Planning and Recommendation System Using ML and MERN Stack" project aims to develop an innovative solution to address the challenge of personalized diet planning and recommendation. With the rising awareness of the importance of nutrition in maintaining overall health and wellness, there is a growing demand for tools that can offer tailored dietary guidance to individuals based on their unique needs and preferences. This project leverages the power of Machine Learning (ML) algorithms and the MERN (MongoDB, Express.js, React.js, Node.js) stack to create a comprehensive and user-friendly platform. The system collects user data encompassing demographic information, health metrics, dietary habits, and goals. Using ML techniques such as regression, classification, and clustering, the system analyzes this data to generate personalized diet plans and recommendations. The backend of the system, built on Node.js and Express.js, manages data storage and processing, while the frontend, developed with React.js, provides an intuitive interface for users to interact with the system. MongoDB serves as the database, ensuring scalability and flexibility in data management. The ML models continuously learn and adapt based on user feedback and outcomes, enhancing the accuracy and effectiveness of the recommendations over time. Reinforcement learning techniques are employed to optimize diet plans based on real-world outcomes and user satisfaction. By integrating ML with the MERN stack, this project offers a novel approach to diet planning and recommendation, empowering individuals to make informed dietary choices and improve their overall health and well-being. KeyWords:Diet Planning ,Recommendation System,Machine Learning,(ML),MERNStack,Personalized,Nutrition,Health,,,Metrics,Dietary,Habits,Regression,Classification,Node.js, ,React.js,,MongoDB,User,Feedback,ReinforcementLearni,Real-world Outcomes,User Satisfaction,Wellness,Informed Dietary Choices
Automated processing of well logging data to monitor the position of the gas-water contact in underground gas storage facilities
Authors:   Ufa University of Science and Technology, Ufa, Russia, Vakhitova G. R. , Valiullin R. A. ,   Ufa University of Science and Technology, Ufa, Russia, Fedotov V. Y. ,   Ufa University of Science and Technology, Ufa, Russia, Mukhutdinov V. K. ,   Ufa University of Science and Technology, Ufa, Russia, Ibadov F. I. ,   SOCAR, Baku, Azerbaijan
Published: April 2024

Natural oil and gas deposits in most fields include some fluid contacts, such as oil–water, gas–water, or gas–oil. Monitoring the position of the gas–water contact in underground gas storage (UGS) facilities is crucial for monitoring the safety of the subsurface environment. As UGS facilities are geological features of long-term operation, the condition of these features must be regularly monitored for possible gas leaks due to various reasons, whether geological or technical. Periodic surveys of production wells using geophysical methods make it possible to timely detect the reasons for abnormal technical conditions and higher-than-normal water cuts of reservoirs, and to assess shifts in gas–water contact. The suite of production logging methods for surveying and monitoring underground gas storage facilities includes nuclear logging with the use of steady radiation sources (i.e., gamma ray logging and neutron logging). Analysis and interpretation of these methods make it possible to track the shift over time of the gas–water contact in gas-saturated sandstones with an interparticle porosity of >15%. Data from nuclear logging, temperature logs, and composition-based and flow-based surveying are processed and interpreted with the use of known methods and diagnostic indicators to achieve the following goals: to determine the intervals of inter-reservoir and behind-the-casing fluid movement on the base of the well log, to assess the technical condition of the wellbore, to monitor the position of the gas–water contact in the reservoir, to assess the gas saturation of the reservoir, and to monitor the thickness and integrity of the clay caprocks of UGS facilities [1]. This paper discusses the results of automated processing and interpretation of well data recorded during the survey of an UGS facility to determine the current position of the gas–water contact in the reservoir and the gas–water interface in the well. Quantitative interpretation of the neutron logging data with the use of steady radiation sources was performed, and the current gas saturation factor was estimated. Keywords: gas–water contact (GWC); gas saturation; underground gas storage; processing algorithm; gas–water interface (GWI).
Innovative methodology for predicting pipe thickness loss based on electromagnetic flaw detection results
Authors:   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Dyshin O. A. , Bakirova L. R. ,   Azerbaijan State Oil and Industry University, Baku, Azerbaijan, Feyziyeva G. E. ,   Azerbaijan State Oil and Industry University, Baku, Azerbaijan
Published: April 2024

The paper proposes an innovative approach to forecasting based on the results of electromagnetic flaw detection to determine maximum pipe thickness losses over 10-m intervals of the immersion depth of the lower part of a pipe into a well. The main model uses rank transformation applied to a fuzzy regression model with fuzzy input variables and fuzzy output. The input variables include the main parameters of the reservoir in the well (temperature, density, and dynamic viscosity of the hydrocarbon mixture), while the output variable is the maximum loss of pipe thickness in the above–mentioned immersion intervals of the lower part of the pipe. The error of the output forecasts is determined using a numerical procedure to estimate the difference between fuzzy numbers. The forecasting is performed using a sliding method that combines rank fuzzy regression with clear nonlinear regression until the prediction error reaches the specified threshold value. The use of fuzzy regression with fuzzy input and output makes it possible to assess the impact of reservoir parameters on the condition of pipes and the potential for emissions and critical situations. Keywords: Fuzzy LR-type numbers; rank transformation; fuzzy regression; electromagnetic flaw detection; fuzzy outliers; sliding prediction; membership function; pipe thickness loss.
Analysis of the performance of financial and economic activities of national oil and gas enterprises (on the example of Uzbekneftegaz JSC)
Authors:   Tashkent Financial Institute, Tashkent, Uzbekistan, Umurzakov J. Sh.
Published: April 2024

Currently, in the Republic of Uzbekistan, unlike the economies of a number of border countries, such as Tajikistan, the Kyrgyz Republic, the oil and gas industry, which includes enterprises engaged in the production of hydrocarbons, their processing at various levels, supply and sale to consumers, is one of the leading sectors of the country’s economy. To support the oil and gas industry in organizing the extraction and production of goods with high added value, it is necessary to create long trade and production chains for advanced processing of raw materials, the formation of large production associations that make it possible to benefit from economies of scale in production. In this article, the contribution of the oil and gas complex industry to the country's economy, the areas of activity are considered on the example of the joint-stock company «Uzbekneftgaz», which is the leader in the field. The position of society in the market and the existing risks in financial and economic activity are considered on the basis of SWOT analysis. We conducted a small analysis of the current situation in the oil and gas market, assessed the activities of one of the leading national companies in the region and the indicators of its development. In our opinion, this analysis allows us to see the development and improvement of companies from a development point of view. Keywords: environmental; SWOT analysis; liquidity; investments; net profit; expenses; rating agencies; hydrocarbon reserves.
Antikçağ Efes Olimpiyat Oyunları
Authors: Korkmaz Sevda
Published: April 2024

Antik dünyanın yedi harikasından biri olan ‘Artemis tapınağı’, bölgenin en büyük kütüphanesi olan Celsus, arkeolojik yapıları ile antikçağ yaşamı ve dinsel inançlar çerçevesinde Efes antik şehri, bilimsel araştırmalar ve hikayelere sıklıkla konu olmuştur. Ancak antik çağ Helen ve Roma dönemlerinde tanrısal kültleri ile öne çıkarılan Efes, bu özelliği ile iç içe geçen biçimde sportif bir yaşama zemin oluşu gölgede kalmıştır. Homeros’un ‘İliada ve Odysseia’ destanlarında anlatılan Küçük Asya kökenli cenaze oyunlarına kadar giden oyun geleneğinin dışında kalmayan Efes’in, oldukça hareketli bir spor merkezi olduğu günümüze kalan stadyum, spor ve rekreasyon yapıları, anıtlar, yazıtlar ve papirüsler gibi birçok belge ve veriden anlaşılmaktadır. Bu denli canlı bir spor yaşamına sahip şehirde düzenlenen önemli etkinliklerinden bir tanesi de Efes Olimpiyatları’dır. 300 yıldan uzun bir zaman boyunca sürdürülen Efes Olimpiyatları; şehirde yapılan sporlar, öne çıkan sporcular, oyunların kuruluşu, finansı ve konumuna dair bilgileri sunan önemli bir etkinliktir. Bu araştırma kapsamında Efes’te kapsamlı bir program ve anlayış içerisinde gerçekleştirilen bu oyunlara dair bilgiler, literatür tarama ve doküman analizi yöntemleriyle incelenerek sunmak amaçlanmıştır.
GCG structure’s and disclosure to investors’ impacts on ROE in non-bank financing sector companies
Authors: Anggraini Nova Tri , Iskandar Rusdiah , Wardhani Wirasmi
Published: April 2024

This study aims to determine the effect of Shareholders' Rights and the Board of Directors as well as the Audit Committee and Disclosure to Investors on Return On Equity in Financing Companies listed on the Indonesia Stock Exchange (Period 2018-2022). Through this quantitative approach, the research method used is descriptive analysis and hypothesis testing with a total population of 20 non-bank financing companies and a sample of 4 non-bank financing companies listed during the 2018-2022 period. The results show that Shareholders' Rights and the Audit Committee have a significant effect on ROE. In contrast, the Board of Directors and Disclosure to Investors show no effect on ROE.
Reviewer Acknowledgements for International Journal of Chemistry, Vol. 16, No. 1
Authors: John Albert
Published: April 2024

International Journal of Chemistry wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Chemistry publishes their work, appreciate the helpful feedback provided by the reviewers.

 

Reviewers for Volume 16, Number 1

 

 

Ahmet Ozan Gezerman, Toros Agri-Industry, Research and Development Center, Turkey

Ayodele Temidayo Odularu, University of Fort Hare, South Africa

Chennaiah Ande, University of Georgia, USA

Ho Soon Min, INTI International University, Malaysia

Hui Tan, Columbia University, USA

Kevin C. Cannon, Penn State Abington, USA

Khaldun Mohammad Al Azzam, The University of Jordan, Jordan

Mohamed Abass, Ain Shams University, Egypt

Mustafa Oguzhan Kaya, Siirt University, Turkey

Nejib Hussein Mekni, Al Manar University, Tunisia

Rafael Gomes da Silveira, Federal Institute of Education, Brazil

Rodrigo Vieira Rodrigues, University of São Paulo, Brazil

Severine Queyroy, Aix-Marseille Université, France

Sitaram Acharya, Dallas College, USA

Tony Di Feo, Natural Resources Canada, Canada

Vinícius Silva Pinto, Federal Institute of Goiás, Brazil

Albert John

On behalf of,

The Editorial Board of International Journal of Chemistry

Canadian Center of Science and Education
The Judicial Scrutiny of Environmental Risk and the Legislative Scheme of the Water Act: A Comment
Authors: John Mathew
Published: April 2024

This paper outlines the central role of risk management in the regulatory toolkit administering Indian environmental law. In particular, it examines the operationalization of risk management in the functioning of Water Act through the management of pollution standards, especially the extent to which standards management has informed adjudication by the higher judiciary and the National Green Tribunal. This examination of adjudication the cases is typed into cases that strictly deal with standards management, cases that deal with procedural objections to regulatory interventions to manage standards and public interest litigation cases. Though the overall number of cases are small, strict standards management cases constitute about a third of the overall number of cases arising out of the standards management provisions of the statute. Drawing on this distribution of cases the paper comments on the nature and limits of standards management as the framework of managing risk in the Water Act. Accordingly, this paper is also an introductory comment on the kind of enquiry that will make salient the framework of risk management that organizes the regulatory framework of the Water Act in particular and Indian environment law in general.
Disruption in Myelination in the Brain by APOE4
Authors: Editorial Staff
Published: April 2024

How the brain is affected by APOE4 -one of the most important genetic risk factors in patients with Alzheimer's disease (AD), is still not clear. This missing piece is a substantial barrier to understanding the risk factors of AD and their use as therapeutic targets. Blanchard and colleagues performed a study to delineate the function of APOE4 by post-mortem transcriptomic analysis of the brains of non-carriers and carriers of APOE4. The data from their results point to the fact that APOE4 influences a host of expression profiles and signaling mechanisms in all of the studied cell types. The most significant effects were observed in the cholesterol homeostasis and transport mechanisms. It was observed that the oligodendrocytes were subjected to abnormal cholesterol metabolism, which subsequently affected the electrical activity of neurons. These results were affirmed using induced pluripotent stem cells, post-mortem human brains, and targeted replacement mice. It was also seen that altered deposition of cholesterol in APOE4 carrier brains reduced myelination. Pharmacological improvement in axonal myelination of APOE4 mice demonstrated better memory and learning. By providing a single-cell atlas of the partaking signaling events, the authors concisely represented the transcriptomic effects of APOE4. A working relationship between cholesterol transport, myelination, and subsequent effects on learning and memory with APOE4 was also provided, thus unveiling potential targets for treating AD. Nature (2022) DOI: 10.1038/s41586-022-05439-w.
A Review On the Sources and Mechanisms of Chemoresistance in Hepatocellular Carcinoma
Authors: Ain Qura Tul , Ali Muhammad , Ahmed Mushood , Rehman Bisma , Ibrahim Ahsan , Bashir Fawad , Shahid Tahreem
Published: April 2024

Degenerative Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related deaths worldwide, with surgical resection followed by chemotherapy being the primary treatment method. However, the complex nature and high metastatic potential of HCC often render treatment plans ineffective, and acquired drug resistance frequently results in disease relapse in patients. In this review, we conducted an extensive literature search of different databases, including Medline, Scopus, and Cochrane, to identify studies that have addressed chemoresistance in HCC. This article provides a comprehensive knowledge of molecular mechanisms of chemoresistance in HCC, including genetic polymorphism, apoptosis, DNA methylation, tumor suppressor genes, DNA repair, topoisomerases, drug efflux, and epithelial-mesenchymal transition. Understanding these mechanisms is crucial for developing personalized combination therapies, identifying chemosensitive populations, and evaluating the effectiveness of chemotherapeutic agents through cell culture and orthotopic models. Therapies that can counter these resistance mechanisms need to be developed to better manage and control the disease. This would increase the patient survival rate and help decrease the use of multiple chemotherapeutic agents that greatly increase the risk of toxicities encountered by patients. Further studies are needed, so a combined effort by healthcare professionals and pharmaceutical companies can be the key to combatting the ever-rising rate of chemoresistance in HCC.
Challenges with Newly Approved CRISPR Gene Technologies
Authors: Ahmed Sagheer
Published: April 2024

CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) technology is a powerful gene-editing tool that allows for precise modification of DNA. While CRISPR has shown immense potential in laboratory and preclinical studies, the development of CRISPR-based therapies for human use is still in the early stages. However, on December 08, the Food and Drug Administration (FDA) of the United States of America approved two milestone treatments, Casgevy and Lyfgenia, representing the first cell-based gene therapies for the treatment of sickle cell disease (SCD) in patients 12 years and older. Several CRISPR-Cas9 therapies that work on the same principle are in clinical trials as treatments for a range of diseases.
However, there are still significant concerns with the use of this new technology. One major concern with CRISPR technology is the potential for off-target effects, where unintended changes may occur in locations other than the target gene.  The introduction of CRISPR components into the body may also trigger an immune response. Several laboratories are investigating ways to mitigate immune reactions and improve the delivery of CRISPR components. The method of delivering CRISPR components into cells is also important for safety. Further research into different delivery methods, such as viral vectors or nanoparticles, would help optimize efficiency while minimizing potential side effects.
The long-term effects of CRISPR-based interventions are an area of ongoing research. Understanding the stability of CRISPR-induced changes over time and potential consequences is crucial for assessing safety. Ethical considerations are important to discussions about CRISPR use, particularly when it comes to editing the human germline (sperm, eggs, embryos), as changes made in these cells would be heritable. The potential for unintended consequences and ethical implications necessitates careful consideration.
It is important to consider that although CRISPR holds great promise, the technology is relatively young, and research is ongoing to address safety concerns. The scientific community and regulatory bodies are actively working to ensure that CRISPR technologies are developed and implemented responsibly. Continuous advancements, ongoing research, and open communication will be essential to addressing safety challenges associated with CRISPR.
Mesiodens: the most common case of hyperdontia – presentation of radiological cases
Authors:   Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Aristotle University of Thessaloniki., Liappis Evangelos , Vlachopanos Zois-Panagiotis ,   Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Aristotle University of Thessaloniki., Impas Christos ,   Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Aristotle University of Thessaloniki., Papadeli Chrysi ,   Department of Dentoalveolar Surgery, Implantology and Oral Radiology, School of Dentistry, Aristotle University of Thessaloniki.
Published: April 2024

Mesiodens is the most common case of supernumerary teeth. It is a very usual developmental abnormality of permanent dentition, either accompanied or not by painful symptomatology and other pathological findings. Mesiodens are often detected by chance, through patients' radiological examination for other reasons. So, radiology and its methods assist in the radiographic estimation of a mesiodens. The purpose of this study is to present the valuable contribution of oral radiology in detecting asymptomatic mesiodens and determining their exact position. Four radiological cases have been chosen for this study. The four patients belong to different age groups (29, 9, 64 and 71 years old accordingly) and are of both genders. Each one came to the School of Dentistry for different dental treatments. Three different radiological technoques of oral radiology have been applied for their examination, namely periapical, panoramic and cone-beam computed tomography radiographs. In all cases, the mesiodens were impacted and asymptomatic, thus detected by chance through the conducted radiographic evaluation. In case of mesiodens, radiology contributes significantly in determining the tooth's characteristics, as in most cases the mesiodens is impacted. All eadiographic methodologies presented in this studyare essential not only for the diagnosis, but also for the surgical management of mesiodens. In case of prosthodontic treatment in edentulous patients, orthodontic treatment or at the presence of pathological findings, the impacted mesiodens should be extracted, Otherwise, the decision depends on the clinical and radiological findings.
La traducción feminista en la práctica del aula. Experiencia docente en el campo de los estudios culturales hispánicos
Authors: Castro Olga
Published: April 2024

A pesar de los retos que pueden presentar los contenidos transgresores en el aula, desde la pedagogía feminista se ha reflexionado sobre las oportunidades que estos presentan para concienciar al alumnado sobre ciertos temas de gran relevancia social. Con todo, abordar la práctica de la traducción feminista de textos transgresores presenta retos adicionales, dada la falta de consenso existente sobre qué son o cómo se materializan las llamadas estrategias feministas de traducción. En este artículo reflexiono sobre mi experiencia docente impartiendo mi asignatura «Gender and Translation in the Hispanic World: Translating Women Writers», en la que la traducción funciona no solo como puerta de acceso a autoras del Caribe, Guinea Ecuatorial, Estado español y Latinoamérica, sino también como poderosa herramienta con la que se fomenta un debate sobre el papel de mediación ideológica del sujeto traductor, aprovechando las oportunidades que brinda la tecnología digital.
Antimicrobial Properties of Cola Nitida
Authors:   Department of Microbiology, Faculty of Life Science, University of Benin, Benin City, Enabulele, O.I. Onaivi, T.J.
Published: April 2024

The antimicrobial evaluation of ethanol, methanol and aqueous extracts of Cola nitida on Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli was experimented. The assay was carried out by agar disc diffusion method. Results showed that the ethanol, methanol and aqueous extracts of the seed were found to be of a relatively higher effect having a zone of inhibition of 5mm against the samples of S. aureus than the other bacteria at the concentration of 400mg/mm. None of the extract was active against P. aeruginosa. E. coli showed a zone of inhibition of 3mm with ethanolic extract but showed a lower zone of inhibition with both methanol and aqueous extract. When compared to standard antibiotics such as septrin, amoxicillin, tetracycline, ampiclox and doxycycline, all the extracts had a high zone of inhibition of 5mm on S. aureus except for doxycycline which showed a higher zone of inhibition on all the test organisms. This antimicrobial property showed by the seed extracts on some of the organisms is an evidence of the ethno-medicinal uses of the plants due to the presence of some phytochemicals such as saponins, tanins, and alkaloids among others. For effective utilization of these Cola seeds as well as other relevant parts of the Cola plant, further research has been recommended.
Perancangan Website Penjualan Toko Online Pada Toko Usaha Tani Mandiri Sintang Dengan Menggunakan Framework Codeigniter
Authors: - Dany Fahrurrozi , David David  , Gusti Syarifudin  , Sandy Kosasi  , Susanti Margaretha Kuway
Published: April 2024

The Mandiri Farming Business Store has a need to be able to increase sales, manage goods/products so that they can be conditioned, and sales or marketing that is classified as conventional, which causes human error and farmers who have to come all the way to the store to get product information. This research aims to build a codeigniter-based sales website that has an MVC concept and a product recommendation system. This will simplify the shop activity process. The scope of the research uses the CodeIgniter framework which has an MVC concept and a product recommendation system to build sales websites. Using the midtrans API as a payment gateway. The form of research used is a case study. The research method used is DSR (Design Science Research). The design method used is the Agile Extreme Programming (XP) method. The results of this research produced a fertilizer and plant seed sales website that provides product and goods information to buyers and makes it easier for buyers to make purchases online. The conclusion of this research is that it facilitates sales and purchase transaction activities in stores. This research suggests adding other features such as delivery services.
What The Thunder Said
Authors: Redmond Walter
Published: April 2024

Eliot considered “What the Thunder Said” the most important part of The Waste Land, and he thought “the twenty-nine lines of the water-dripping song… were good”.
The Burnt Norton
Authors: Redmond Walter
Published: April 2024

1935. AIR is the symbol of the first quartet.
Experiência docente e a relação com o saber
Authors: Silva Ana Paula Ferreira da
Published: April 2024

Esse estudo investiga os ciclos de vida profissional na relação com o saber docente durante o primeiro ano de aulas remotas. O objetivo é compreender a relação com o saber docente, a partir da premissa de que havia poucas experiências, recursos e orientações que pudessem subsidiar as escolhas e as práticas docentes. Os dados foram coletados por questionário online e tratados nos softwares estatísticos Sphinx iQ2 e Minitab. As análises fundamentam-se em Charlot, Tardif, Huberman, Cavaco, Hargreaves e Fullan. As mudanças em relação à docência foram sentidas pelos professores com mais tempo de docência que precisaram reaprender o saber-fazer da prática docentes. Embora as aprendizagens e adaptações das práticas pedagógicas sejam significativas, o desejo de saber se confundiu à representação do saber, pois parecem ser resultado da urgência e das demandas externas impostas e não uma possibilidade desejável e desejada pelos professores.
Adaptações jurídicas em direito de família: as novas configurações familiares
Authors: Souza Lindsei Santos , Cavalcante Jéssica Painkow Rosa
Published: April 2024

O Projeto de Lei (PL) nº 5.167/2009 propõe uma definição restritiva de família, limitando-a à união entre homem e mulher e excluindo outras formas familiares, como as uniões homoafetivas. Essa proposta entra em conflito com a decisão do Supremo Tribunal Federal (STF) nas Ações Diretas de Inconstitucionalidade (ADI) nº 4.277 e na Arguição de Descumprimento de Preceito Fundamental (ADPF) nº 132, que reconheceram as uniões estáveis homoafetivas como entidades familiares. O PL, ainda em tramitação, suscita debates sobre a constitucionalidade e os possíveis impactos nas configurações familiares contemporâneas. Enquanto seus defensores argumentam pela preservação dos valores tradicionais da família, seus críticos apontam para a inconstitucionalidade da proposta e sua contradição com os avanços na jurisprudência do STF. A análise crítica do projeto à luz das decisões do STF visa identificar possíveis conflitos normativos e implicações para os direitos das novas configurações familiares. A pesquisa combina análise bibliográfica e comparação entre o PL e as decisões do STF, visando oferecer uma visão abrangente dos desafios legais e sociais envolvidos na possível aprovação do projeto e destacar a importância de uma legislação inclusiva e atualizada para a proteção e reconhecimento das diversas formas de família na sociedade contemporânea.
Os saberes do professor do curso de direito a partir da análise de narrativas docentes
Authors: Lima Gisele Laus da Silva Pereira , Moretto Milena
Published: April 2024

Este artigo tem como objetivo investigar os saberes necessários para a docência universitária no ensino jurídico, fundamentando-se na perspectiva enunciativo-discursiva, que considera a linguagem como dialógica. Para tanto, como procedimento metodológico utilizou-se a entrevista narrativa com dois professores do Curso de Direito de uma instituição privada do interior de São Paulo, que permitiu analisar as histórias de vida dos docentes e os significados que eles atribuem aos saberes que entendem necessários para serem professores. Os resultados apontam que os saberes valorizados pelos professores são aqueles relacionados à sua área de atuação profissional e experienciais à sua prática pedagógica. As análises demonstram que a docência universitária como uma profissão requer saberes específicos, e especificamente no ensino jurídico possuem os desafios e as demandas da sociedade contemporânea que vão além de um viés profissional, mas uma formação que deve ser comprometida com a interação humana e a reflexão sobre a diversidade dos problemas sociais.
Histomorphological changes in gills and hepatopancreas of crabs: an integrative review
Authors: Vasconcelos Yara Nantes , Metri Cassiana Baptista , Predes Fabrícia de Souza
Published: April 2024

Crustaceans are a biological model of ecotoxicology and consequently are widely used to assess the impact of xenobiotics. The toxicity of xenobiotics starts in the interaction of biomolecules and can even cause changes in an entire ecosystem. This paper aims to compile the histomorphological changes caused by xenobiotics in the gills and hepatopancreas of crabs through an integrative review. The literature search was done using PubMed with keywords in English and the filters "full text" and "publications from 2001-21". A total of 299 studies were found and 35 of them were selected based on the title and abstract. Later, 17 were included in the study. There were 18 categories of histomorphological changes in the gills and 22 in the hepatopancreas. We noticed that there is no consensus on the terminology used for histomorphological changes in this group. Furthermore, it was observed that the quality of the histological slides was quite diverse, making the identification and comparison of changes in the images problematic. The aforementioned considerations justify the need for this study to address a gap and encourage future research to develop a guide of histomorphological changes in crabs and its use as a tool for environmental biomonitoring.
Trajétorias não lineares rumo a docência: de discente egresso da 1ª turma a docente em enfermagem
Authors: Mendes-Rodrigues Clesnan , Cunha Cristiane Martins , Gomes Fabiola Alves
Published: April 2024

A chegada ao ensino superior, como docente, pode seguir diferentes trajetórias: as lineares (da pós-graduação direto à docência), as não lineares (que permeiam outros caminhos, antecedendo o acesso a docência) ou um misto das duas. Neste sentido, o presente trabalho tem como objetivo relatar as experiências de três egressos da 1ª Turma de Graduação em Enfermagem da Universidade Federal de Uberlândia (UFU) rumo à docência no curso de graduação de Enfermagem da UFU. Observamos a ocorrência de trajetórias não lineares e distintas entre os egressos, mas com a formação concentrada na UFU, face à necessidade de manutenção de vínculos empregatícios. Os docentes tiveram experiências em outras instituições nacionais e internacionais, as quais foram possíveis graças às bolsas acadêmicas e à estabilização profissional. Os dados reforçam ainda que as trajetórias individuais e as formações complementares em outras áreas tiveram impacto na atuação dos docentes nas mais diversas atividades de ensino, pesquisa e extensão.
Perfil sociodemográfico dos óbitos por neoplasia maligna de estômago em um estado do Norte brasileiro
Authors: Ramos Leonardo de Paula , Damasceno Edmilson dos Santos , Luz Jefferson Barreto da , Cardozo Jhonatan Jones Oliveira , Fecury Amanda Alves
Published: April 2024

Introdução: o câncer de estômago representa um desafio significativo para a saúde pública devido à sua alta incidência e impacto na morbidade e mortalidade. Além de ser uma das neoplasias malignas mais comuns em todo o mundo, é frequentemente diagnosticada em estágios avançados, o que dificulta o tratamento e reduz as taxas de sobrevida dos pacientes. Objetivo: identificar o perfil sociodemográfico dos óbitos por neoplasia maligna de estômago no estado do Amapá. Método: estudo epidemiológico descritivo de série temporal. Foram incluídos todos os óbitos por neoplasia maligna do estômago registrados no Sistema de Informações de Mortalidade (SIM), disponibilizado pelo Departamento de Informática do Sistema Único de Saúde (Datasus), no período de janeiro de 2013 a dezembro de 2022, no Estado do Amapá. Realizou-se a análise descritiva dos dados, por meio da determinação de frequências absolutas e relativas. Resultados: dos 541 casos registrados, houve maior acometimento desse agravo entre indivíduos do sexo masculino (68,6%), com idade superior ou igual à 60 anos (61,2%), raça/cor parda (66,3%) e tempo de escolaridade de um a sete anos (44%). Ao observar os dados por ano registrado, em 2019 identificou-se o maior número de óbitos registrados (n=72) e foi possível notar o aumento da frequência dos óbitos registrados do ano de 2013 ao de 2022, entre indivíduos do sexo feminino (28,3% e 32,1%), na faixa etária de 30-59 anos (30,4% e 39,6%), pardos (60,9% e 68%) e com escolaridades de oito a 11 anos (10,9% e 15,1%) e maior ou igual a 12 anos (4,3% e 15,1%). Conclusão: os achados reforçam a necessidade de uma abordagem integrada e abrangente no enfrentamento do câncer de estômago, com foco na promoção da saúde, prevenção e tratamento adequado para a redução dos impactos desse agravo na saúde pública, favorecendo desfechos clínicos e epidemiológicos associados a essa neoplasia.