bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of bioactive peptides from marine industrial waste for moon cake preservation by coating
Authors: Lu Dongmei , Chen Yanhong , Xie Qiaoling , Qiu Ziting , Zhang Hongyan , Sun Peng , Pan Jinquan , Wang Yun
Published: October 2022

In this study, fish marine bioactive peptides (FMBP) from gill waste obtained from Tilapia (Oreochromis mossambicus) and bighead carp (Hypophthalmichthys nobilis) were explored to provide a green preservation method to maintain the taste and flavor of Chinese moon cake. FMBP were hydrolyzed using a mixture of protease (neutral protease: alkaline protease = 1:1). The enzymatic reaction conditions were researched by single‐factor experiments with antibacterial activity as the evaluation index. Moon cakes were treated with FMBP coating (2.0%, 2.5%, 3.0% or 3.5%) and stored for 25 days at 28°C without packaging. The effect of FMBP on the quality of moon cakes was investigated considering microbiological, physicochemical and sensory properties. Research showed that FMBP significantly inhibited the growth of microorganisms during storage while maintaining the taste of moon cake. The 3% FMBP had the best effect on the coating treatment, which the PV and AV values reduced most significantly (p < 0.05), and especially the total number of colonies (p < 0.05) and the number of coliforms (p < 0.01) was significantly inhibited. The shelf‐life of moon cakes treated with FMBP coating was extended, 2% FMBP by 10 days and 3% or 3.5% FMBP by 20 days, compared with the control group without FMBP treatment by 5 days (when the total number of molds was more than 150 CFU/g, the moon cake was spoiled). These results indicate that FMBP can be used as a food additive antimicrobial agent and preservative.

Novelty Impact Statement

The optimal FMBP enzymatic hydrolysis conditions were obtained, which could be used in the field of food additive antimicrobial or preservative agent. FMBP significantly inhibited the growth of microorganisms during storage while maintaining the quality of moon cakes. The 3% FMBP had the best effect on the coating treatment, which the shelf‐life of moon cakes was extended by 20 days.
Effect of illuminance and colour temperature of LED lighting on asthenopia during reading
Authors: Chen Yilin , Ma Tianju , Ye Zi , Li Zhaohui
Published: October 2022

Purpose

A self‐controlled study to determine the influence of illuminance and correlated colour temperature (CCT) of light‐emitting diode (LED) lighting on asthenopia.

Methods

Twenty‐two healthy postgraduates (nine women) were recruited to read under eight LED lighting conditions with four illuminances (300 lx, 500 lx, 750 lx and 1000 lx) and four CCTs (2700, 4000, 5000 and 6500 K) for 2 h. A subjective asthenopia questionnaire, the optical quality analysis system (OQAS) and an inflammatory cytokine assay were used to assess the levels of asthenopia.

Results

Increased asthenopia was observed after reading, but the degree varied with lighting conditions. There were significant differences among the groups in terms of subjective symptoms (inattention, eye pain, dry eye and total score), optical performance parameters (modulation transfer function [MTF] cut‐off frequency, Strehl ratio [SR], objective scattering index [OSI], mean OSI and accommodative amplitude [AA]) as well as inflammatory cytokines in the tears (epidermal growth factor [EGF], transforming growth factor [TGF]‐α, interleukin [IL]‐6, IL‐8, macrophage inflammatory protein [MIP]‐1β, tumour necrosis factor [TNF]‐α, TNF‐β and vascular endothelial growth factor [VEGF]‐A). All of the subjective and objective measurements collectively suggested that asthenopia was lessened for the 500 lx–4000 K condition. However, asthenopia was significantly worse for 300 lx–2700 K and 1000 lx–6500 K in terms of subjective symptoms and objective optical performance, respectively.

Conclusions

LED illuminance and CCT do have a significant effect on asthenopia during reading. 500 lx–4000 K lighting resulted in the lowest level of asthenopia. Conversely, low illuminance at low CCT (300 lx–2700 K) and high illuminance at high CCT (1000 lx–6500 K) promoted more severe asthenopia.
The growth‐immunity tradeoff in Brassica oleracea‐Xanthomonas campestris pv. campestris pathosystem
Authors: Vega‐Álvarez Carmen , Francisco Marta , Cartea María Elena , Fernández Juan Carlos , Soengas Pilar
Published: October 2022

Plant responses against pathogens are influenced by growth immunity tradeoff, which ensure the best use of limited resources. We study how the immobilization of carbon resources and the induction of defensive responses (glucosinolates, phenolic compounds, stomatal closure) can influence the biomass of two Brassica oleracea lines, differing in their resistance, after infection with Xanthomonas campestris pv. campestris. Potentially, the growth immunity tradeoff can be influenced by the activation of all these processes. However, on the contrary of which is normally stated, our results suggest that the loss of biomass caused by pathogen infection is mainly due to the differential accumulation of starch and the immobilization of sugars rather than the reallocation of resources to synthesize secondary metabolites. Moreover, resistance may be related to the effectiveness of the tradeoff, since the resistant line immobilizes resources more efficiently than the susceptible one. Both inbred lines show a different phytohormones profile, which support the hypothesis that they are employing different strategies to defend themselves against the pathogen. This study emphasizes the key role of the primary metabolism in the defence strategies of plants against pathogens.
Longitudinal lung function in urban firefighters: A group‐based multi‐trajectory modelling approach
Authors: Pendergrast Catherine , Boyle Terry , Crockett Alan J. , Eston Roger , Johnston Kylie N.
Published: October 2022

Background and Objective

Urban firefighters are routinely exposed to both physical and chemical hazards that can negatively impact lung health, but it is unclear if firefighters experience accelerated decline in spirometry parameters due to chronic exposure and acute insults. This study aimed to describe sub‐groups of firefighters with differing spirometry trajectories and examine the relationship between the identified trajectories and demographic, lifestyle and occupational characteristics.

Methods

Data from six waves of the Respiratory Function Measurement and Surveillance for South Australian Metropolitan Fire Service Study (2007–2019) were used to identify spirometry parameter z‐score trajectories, using group‐based multi‐trajectory modelling (GBMTM). Analysis of variance and chi‐square statistics were used to assess trajectory group differences in baseline self‐reported demographic, lifestyle and occupational characteristics.

Results

In the 669 included firefighters, we identified five trajectories for the combination of Forced Expiratory Volume in the first second z‐score (FEV1z), Forced Vital Capacity z‐score (FVCz) and the ratio of FEV1 and FVC z‐score (FEV1/FVCz). There were three stable trajectories of low, average and very high lung function and two declining trajectories of average and high lung function. Analysis of subgroup characteristics revealed no significant differences between expected and actual group proportions for the occupational characteristics of years of service and respiratory protection use. Significant differences were seen in respiratory health and body mass index.

Conclusion

GBMTM defined distinct, plausible spirometry trajectory sub‐groups. Firefighter longitudinal spirometry trajectory group membership was associated with BMI and respiratory disease or symptoms but not with self‐reported smoking history or occupational factors.
Identification of the novel HLA‐A*24:02:01:136 allele in a Northern Indian individual from a Muslim family
Authors: Tambe Manisha , D'Silva Selma Z. , Rajak Jyoti , Pinto Andrea S. , Singh Meenakshi
Published: October 2022

The novel allele HLA‐A*24:02:01:136 as compared with HLA‐A*24:02:01:01 displays a single nucleotide polymorphism at position; gDNA 2827 (C > A).
Clinical outcomes of canine total hip replacement utilizing a BFX lateral bolt femoral stem: 195 consecutive cases (2013–2019)
Authors: Kwok Jenny Y. , Wendelburg Kirk L.
Published: October 2022

Objective

To evaluate the clinical outcomes of total hip replacements (THR) utilizing a BFX lateral bolt stem in dogs with coxofemoral joint disease.

Study design

Retrospective study.

Sample population

A total of 149 dogs representing 195 THR.

Methods

Consecutive THRs utilizing a BFX lateral bolt stem were studied. Preoperative, immediate postoperative, 1‐, 2‐, 3‐, 4‐, and 12‐month postoperative radiographs were performed. All major and minor complications, revisions, outcomes, subsidence, canal flare index (CFI) were recorded.

Results

An intraoperative complication rate of 11.8% was observed. The postoperative complication rate was 13.6%, with 9.2% major and 4.4% minor complications. Complications included: postoperative femur fractures (3.6%), coxofemoral luxation (3.6%), stem failure (0.5%), septic loosening (0.5%), aseptic loosening (0.5%), and acetabular fracture (0.5%). Three dogs underwent prophylactic plating after subjective assessment of cortical thickness. Five of 195 (2.6%) cases underwent explant of their prostheses (median = 3 months). Mean stem subsidence at 1 month postoperatively was 1.22 ± 0.16 mm. An increased CFI was associated with postoperative femur fractures (p < .05). A total of 190 of 195 (97.4%) cases returned to normal function in the long‐term follow‐up period.

Conclusion

Use of the BFX lateral bolt stem resulted in minimal postoperative subsidence, a low femoral stem complication rate, and a high rate of achieving normal limb function.

Clinical significance

The BFX lateral bolt stem should be considered in canine THR as the femoral failure rate is low and the long‐term success rate is high.
An improved method to access initial states in relativistic heavy-ion collisions
Authors: Bhatta Somadutta , Bairathi Vipul
Published: October 2022

Observables in heavy-ion collisions are generally categorized into centralities, which reflect an average over events within a range of impact parameters including a wide variety of initial-state configurations. A multiple binning method using spectator neutrons within each centrality has been shown to provide access to events with rare initial-state conditions. This work suggests an improvement in quantifying the difference between standard centrality and spectator neutron binning towards accessing the initial-state properties. A selection of events with higher initial-state density at a fixed participating nucleon number was observed to result in larger final-state particle production and smaller elliptic flow. The relative difference between observables in centrality and spectator binning shows reduced sensitivity for the observables dominated by impact parameter fluctuations in the initial state, such as triangular flow. This property renders the spectator binning method a good candidate for separating geometric contributions from random fluctuations in the initial state towards final-state observables.
Relativistic spin dynamics conditioned by dark matter axions
Authors: Silenko A. J.
Published: October 2022

The relativistic spin dynamics defined by the pseudoscalar field of dark matter axions is rigorously determined. The relativistic Hamiltonian in the Foldy–Wouthuysen representation is derived. It agrees with the previously obtained nonrelativistic Hamiltonians and the relativistic classical estimation of the axion wind effect. In the relativistic Hamiltonian, the biggest term describes the extraordinary (three orders of magnitude) enhancement of the axion wind effect in storage ring experiments as compared with experiments with immobile particles. This term defines the spin rotation about the longitudinal axis. The effects caused by the axion-induced oscillating EDM and the axion wind consist in the spin rotations about the different horizontal axes and phases of stimulating oscillations differ by$$\pi /2$$π/2. Experiments in a search for dark matter axions has been discussed. The two experimental designs for axion search experiments in storage rings have been elaborated.
A study of potential laser-induced degradation in remote standoff Raman spectroscopy for wall paintings
Authors: Li Yu , Suzuki Amelia , Cheung Chi Shing , Gu Yuda , Kogou Sotiria , Liang Haida
Published: October 2022

A mobile remote standoff Raman spectroscopy system operational at typical distances of 10 m was developed specifically for research of historical sites and wall paintings recently. Here we present an upgrade to that system informed by a thorough experimental investigation of the relevant laser-induced degradation issues. Reflectance spectroscopy as a more sensitive technique than Raman spectroscopy was used for monitoring and a new phenomenon of reversible alterations was detected in many paint samples at very low laser intensities of less than 1 W/cm2 when Raman measurements detected no changes. Contrary to conventional wisdom, the intensity threshold for safe operation was found to decrease significantly for larger incident irradiation area in the case of a vermilion oil paint sample. Damage threshold in intensity for each material needs to be determined for different spot sizes, which can be orders of magnitude lower for 1 mm spot size compared with micro-Raman. Results from this study is also relevant to portable Raman systems which use similarly large spot sizes. However, the larger spot size still generates more Raman photons overall under safe operation than micro-Raman systems. Continuous-wave (CW) lasers are found to be best suited to efficient, that is more Raman signal detected over a given measurement time, and safe Raman operation than ns-pulse lasers at the same wavelength. While the damage threshold in intensity for ns-pulse lasers is much higher than that of CW lasers, the pulse energy allowed in one pulse for safe operation is still too low to allow detection of Raman signal, and the need for multiple pulses makes pulse laser inefficient owing to the low repetition rate necessary to ensure adequate heat dissipation between pulses. The safety of the upgraded system was evaluated and found that no permanent laser-induced degradation was detected within 60 s of laser irradiation for any of the paint samples.
Identification of Oxidative Stress-Associated Molecular Subtypes and Signature for Predicting Survival Outcome of Cervical Squamous Cell Carcinoma
Authors: Wang Lei , Qu Hui , Ma Xiaolin , Liu Xiaomei
Published: October 2022

Background. Cervical squamous cell carcinoma (CESC) is the gynecologic malignancy with high incidence rate and high mortality rate. Oxidative stress participates in gene regulation and malignant tumor progression, including CESC. Methods. RNA-seq, clinical information, and genomic mutation were from The Cancer Genome Atlas- (TCGA-) CESC and GSE44001 datasets. Oxidative stress-related genes were obtained from the gene set enrichment analysis (GSEA) website. ConsensusClusterPlus was used for clustering, which was assessed by the Kaplan-Meier (KM) survival curve analysis, mutation analysis, immunocharacteristic analysis, and therapy. Prognostic signatures were built by combining weighted correlation network analysis (WGCNA), least absolute shrinkage and selection operator (LASSO) algorithm, and stepAIC. The prognostic power of this model was evaluated using the KM survival curve analysis, receiver operating characteristic (ROC) curve analysis, nomogram, and decision curve analysis (DCA). Results. 218 of the 291 CESC cases (74.91%) presented oxidative stress-related gene mutation, especially FBXW7. Three clusters were determined based on oxidative stress-related genes, among which cluster 3 (C3) presented low-frequency mutation and hyperimmune state and was sensitive to immunotherapy. This research developed a 5-gene oxidative stress-related prognostic signature and a RiskScore model. As shown by ROC analysis, in the TCGA and GSE44001 datasets, the RiskScore model showed a high prediction accuracy for 1-, 3-, and 5-year CESC overall survival. High RiskScore was associated with enhanced immune status. The nomogram model was greatly predictive of the overall survival of CESC patients. Conclusion. Our prognostic model was based on oxidative stress-related genes in CESC, potentially aids in CESC prognosis, and provides potential targets against CESC.
An Autopsy Case of Rapidly Aggravated Clostridium perfringens Septicemia with Colorectal Cancer
Authors: Kohya Risako , Murai Taichi , Taguchi Yudai , Sawai Kyohei , Takehara Masaya , Nagahama Masahiro , Itaya Kazufumi , Koike Yuta , Endo Ayana , Ono Yuji , Nagasaka Atsushi , Nishikawa Shuji , Nakamura Michio
Published: October 2022

This report presents a case of a 60-year-old man who was diagnosed with ascending colon cancer with metastases of the lymph nodes and multiple liver metastases. Three days before the introduction of the first chemotherapy, he visited our hospital due to high fever. The blood test revealed an increase in the inflammatory response, hepatobiliary enzyme level, lactate dehydrogenase (LDH) level, and renal function deterioration. Contrast-enhanced computed tomography (CT) showed a rapid progression of primary lesion and liver metastatic lesions. Treatment with 5-fluorouracil, leucovorin, and oxaliplatin and cetuximab (FOLFOX/Cmab) was initiated, and the patient was admitted to our hospital after the first day of chemotherapy. At midnight, he had chills, red urine, and rapid hypoxemia. The second blood test showed progression of anemia; increased total bilirubin, aspartate aminotransferase, and LDH levels; and decreased platelet and fibrinogen levels. The serum was red wine in color, indicating marked hemolysis. The respiratory condition rapidly deteriorated, and tracheal intubation was performed and transferred into the intensive care unit. However, blood oxygenation did not increase, and the patient died the next morning, 19 h after admission, despite intensive care. Postmortem CT showed intraperitoneal free air and gas retention in the liver tumor and portal vein system. Pathological autopsy revealed perforation in ascending colon cancer, many Gram-positive rods in the perforation site, dissemination of bacteria throughout the body, and diffuse pulmonary edema. Subsequently, blood cultures reported Clostridium perfringens (CP), which is a product of alpha-toxin. CP infection can cause rapid aggravation and sudden death. The physicians should be aware of this highly fatal infection, leading to immediate diagnosis and treatment.
An Economic Analysis of Tourism Contribution for Urban Poverty Reduction in Major Tourist Towns of North Shewa Zone, Amhara Region, Ethiopia
Authors: Fikire Abebaw Hailu , Bires Zemenu , Emeru Girma Mulugeta
Published: October 2022

Tourism has a significant contribution to the livelihood diversification of the communities and supporting economic development efforts. This study aimed at an economic analysis of tourism’s contribution to urban poverty reduction in Major Tourist Towns of North Shewa Zone, Amhara Region, Ethiopia. A multistage simple random sampling and purpose sampling were used to select sample respondents from the population in the study area. Hence, a total of 286 valid observations from 385 sample respondents were used for the analysis of the collected data. Both descriptive and inferential statistics were used to analyze the data. The finding of this study revealed that tourism has a significant and positive contribution to poverty reduction in urban areas, but the level of contribution is minimal. Besides, it exhibited that funding aids and government concern for tourism-targeted programs and access to credit infrastructure, tourism education, and policy were the significant factors that affect tourism’s role in urban poverty reduction. Thus, to enhance its contributions and overcome industry bottlenecks, the government shall put tourism as a valuable development pillar, develop pro-poor strategies linking tourism with the urban poor, develop urban tourism development programs, and assign tourism-trained professional leaders to the sector.
Lysophosphatidic Acid Induced Apoptosis, DNA Damage, and Oxidative Stress in Spinal Cord Neurons by Upregulating LPA4/LPA6 Receptors
Authors: Yang Yifan , Xu Jing , Su Qingxin , Wu Yiran , Li Qizheng , Ma Zongren , Ding Tao
Published: October 2022

Lysophosphatidic acid (LPA) has disruptive effects on lumbar spinal stenosis (LSS). Recently, LPA has been reported to be involved in spinal cord neuronal injury and toxicity, promoting the pathogenesis of LSS. However, the exact effects of LPA on spinal cord neurons remain unknown. The purpose of this study is to investigate the effects of LPA (18 : 1) on spinal cord neuronal cytotoxicity, apoptosis, DNA damage, and oxidative stress. After clinical detection of LPA secretion, spinal cord neurons were treated with LPA (18 : 1); cell viability was analyzed by MTT assay, and LDH leakage was detected by LDH kit; cell apoptosis was detected by flow cytometry; ROS production was measured by DCFDA staining and MitoSOX Red Staining; the activation of the Gα12/Gα13 signaling pathway was detected by serum response factor response element (SRF-RE) luciferase reporter gene; the relationship among LPA, LPA4/6, and ROCK was examined by western blotting. In spinal cord neurons treated with LPA (18 : 1), cellular activity decreased and LDH release increased. The Rho kinase inhibitor (Y-27632) can attenuate LPA-induced apoptosis, DNA damage, and oxidative stress in spinal cord neurons. Moreover mechanistic investigation indicated that LPA (18 : 1) activates Gα12/13–Rho–ROCK2-induced apoptosis, DNA damage, and oxidative stress in spinal cord neurons by upregulating LPA4/LPA6 receptors. Further, the Rho kinase inhibitor Y-27632 attenuates the effects of LPA by downregulating LPA4/LPA6 receptors. Taken together, the possible mechanism by which LPA secretion in LSS patients aggravates patient injury was further elucidated using an LPA-induced spinal cord neuronal injury cell model in vitro.
[Retracted] Analysis of the Impact of the Traditional Literature Environment Based on Big Data Technology on Overseas Literature
Authors: Ding Qing
Published: October 2022

To study the influence of conventional literature on foreign literature driven by big data, this essay begins with surveys and interviews. Chinese big data‐driven corpora are distinct from other Chinese corpora, as is widely known. Its main objective is to categorize professional corpora that are unknown and fall within the category of professional corpora. In order to provide a straightforward and useful domain partitioning model for corpus texts, this research makes use of text clustering and big data‐driven methodologies. We can easily determine the domain of the aligned text, making it easier to do machine translation research in the future. The research findings demonstrate that the accuracy rate of the approach suggested in this article is essentially above 89.79%, demonstrating the viability of the way of automatically building a corpus suggested in this paper in the experiment.
Early Clinical Outcomes of ACL Reconstruction Using Semitendinosus Tendon Combined with LARS Synthetic
Authors: Zhang Baocai , Xiang Peng , Bian Shuai , Wang Yibo , Wang Yu , Ma Yuzhuo
Published: October 2022

Objective. To compare the early clinical outcomes of ACL reconstruction using the augmented semitendinosus tendon combined with LARS synthetic material and the autologous hamstring tendons. Methods. A total of 68 eligible patients with ACL rupture were reconstructed using either 4-strand autologous hamstring tendons, representing the control group, or the LARS synthetic material augmented grafts. The duration of postoperative swelling and recovery exercise was recorded. Lysholm and IKDC scores were used for evaluation of knee joint function. Lachman and pivot shift tests were conducted to evaluate stability. Results. The scores of the three knee functions in cases of the augmentation group were significantly higher than those of the control group 6 months after surgery (

P
<
0.05

). There were no significant differences in Tegner score in the two groups 12 months after surgery (

P
>
0.05

). In general, the augmentation group returned to exercise 12 weeks after surgery, while the control group required 30 weeks. Conclusions. The present study indicates that synthetic material augmentation grafts allow earlier return to exercise and display more satisfactory results compared with the control group.
Information Extraction and Data Planning of Smart City Based on Internet of Things
Authors: Farisi Zeyad
Published: October 2022

In order to solve the problem of slow resource scheduling in the process of smart city management, the author proposes a smart city information extraction and data planning system based on the Internet of Things. IoT requires different technologies for analysis for different data types. Managers use different IoT applications to analyze data from different devices and integrate relevant data for possible machine failure or emergency in smart home applications. Situation is predicted. The system includes a cloud platform intelligence center, uses the cloud management module to monitor various hardware devices, constructs the cloud computing resource scheduling objective function, uses the cultural particle swarm algorithm to solve the objective function, and obtains the cloud computing resource scheduling scheme. The experimental results show that the overall utilization rate of the system is the best, close to 100%. Conclusion. The system can realize the effective management of the smart city and monitor the city situation in real time. When implementing resource scheduling, the task completion time is short, the system utilization rate is high, and the resources can be maximized.
In Vitro Evaluation of the Cytotoxic Potential of Environmental Contaminant Mixtures Present in Water for Human Use
Authors: Hakeem Israa J. , Amare Ngiste
Published: October 2022

Chemicals from Pharmaceuticals and Personal Care Products (PPCPs) have become much more prevalent in the environment in recent years. The effects of these substances on human health and the environment are frequently debatable because they typically have poorly understood mechanisms of toxic action. For this reason, we set out to evaluate a binary mixture consisting of butylhydroxyanisole (BHA) and propylparaben (PPB), two approved additives that have been found in the environment and have a range of health-related effects. Based on our prior research, we chose an experimental model called Vero cells, kidney fibroblasts from the African green monkey ( Chlorocebus aethiops), with high sensitivity in toxicology studies and ideal characteristics for the analysis of chemical compounds’ mechanisms of action. The experimental design includes a battery of tests using many complimentary biochemical and morphological biomarkers, the usefulness of which we have previously established. The outcomes demonstrated that the mixtures of BHA and PPB cause significant functional alterations brought on by osmotic imbalance, which are connected to irregularities in cell cycle progression, increases in ploidy, which included cell cycle imbalances as well as increases in proliferation. On the other hand, we have been able to show that the quantitative estimate of the anticipated cellular responses generally does not adjust precisely to the observed effect through the analysis of the prediction of the combined effect using mathematical models. However, once the individual compounds’ respective mechanisms of action have been established, the toxicity caused by the mixtures can be qualitatively predicted.
Construction and Computation of the College English Teaching Path in the Artificial Intelligence Teaching Environment
Authors: Liu Shaojie
Published: October 2022

Today, English is the world’s main international language and is widely spoken. In this context, the learning of English has long been valued by all countries. In addition, English plays an essential role in the process of economic globalization, specifically in the majority of countries where English is not the native language. At the same time, as China’s integration into the world grows, the importance of English has become more pronounced, and the demand for English language skills has increased. At present, China’s ever-expanding opening to the outside world, its developing science and technology, and its rising international status have created an urgent need for English-speaking professionals. This will lay the foundation for China’s economic and social development and enable China to play a greater and more active role in international affairs, which has great practical and far-reaching historical significance. At present, the traditional English teaching mode has been criticized due to a great number of issues. At the same time, the new English language standards and the change of evaluation methods have created new demands on English teaching methods. As a result, with the development of artificial intelligence technology, the application of artificial intelligence technology in the field of education has brought new directions for the optimization of English classroom. In addition, diversified network technologies also provide new support for the realization of intelligent and collaborative English classroom teaching. To be specific, the maturity of English intelligent speech synthesis and intelligent speech evaluation technologies has enabled intelligent technologies to reach or even surpass the level of human teachers in certain areas. However, due to the limitations of the market environment and evaluation methods, the products that can focus on English classroom teaching are not highly intelligent and less collaborative. What is more, the process of English classroom intelligence has stagnated compared to other subjects. Obviously, from the perspective of integrating artificial intelligence technology with English classroom, it is quite necessary and feasible to design and develop an intelligent teaching assistant that can be applied to college English teaching. As information technology continues to evolve, both national and teacher levels are beginning to focus on how it can be better used in the teaching of subjects. Therefore, the use of online information technology in teaching and learning presents a great opportunity for research and practice in English language learning at the university level.
KCNH6 Enhanced Hepatic Glucose Metabolism through Mitochondrial Ca2+ Regulation and Oxidative Stress Inhibition
Authors: Zhang Ying-Chao , Xiong Feng-Ran , Cheng Cheng , Shen Han , Zhao Ru-Xuan , Zhu Juan-Juan , Zhang Lin , Lu Jing , Yang Jin-Kui
Published: October 2022

KCNH6 has been proven to affect glucose metabolism and insulin secretion both in humans and mice. Further study revealed that Kcnh6 knockout (KO) mice showed impaired glucose tolerance. However, the precise function of KCNH6 in the liver remains unknown. Mitochondria have been suggested to maintain intracellular Ca2+ homeostasis; ROS generation and defective mitochondria can cause glucose metabolism disorders, including type 2 diabetes (T2D). Here, we found that Kcnh6 attenuated glucose metabolism disorders by decreasing PEPCK and G6pase abundance and induced Glut2 and IRS2 expression. Overexpression of Kcnh6 increased hepatic glucose uptake and glycogen synthesis. Kcnh6 attenuated intracellular and mitochondrial calcium levels in primary hepatocytes and reduced intracellular ROS and mitochondrial superoxide production. Kcnh6 suppressed oxidative stress by inhibiting mitochondrial pathway activation and NADPH oxidase expression. Experiments demonstrated that Kcnh6 expression improved hepatic glucose metabolism disorder through the c-Jun N-terminal kinase and p38MAPK signaling pathways. These results were confirmed by experiments evaluating the extent to which forced Kcnh6 expression rescued metabolic disorder in KO mice. In conclusion, KCNH6 enhanced hepatic glucose metabolism by regulating mitochondrial Ca2+ levels and inhibiting oxidative stress. As liver glucose metabolism is key to T2D, understanding KCNH6 functions may provide new insights into the causes of diabetes.
Evaluation of the Reproductive Performance, Body Proportions, Nutritional Value, and Biochemical Parameters of Achatina achatina
Authors: Tchowan Guy Merlin , Toukala Jean Paul , Ngoula Ferdinand , Tchoumboué Joseph
Published: October 2022

To assess the effect of energy levels on the reproductive performance of African Land Snails, ninety young snails of one month of age, weighing between 1 and 1.5 g, of shell length between 15.5 and 23.85 mm and shell diameter between 12.60 and 16.85 mm and free from wounds or shell defects were divided into 3 groups of 5 snails each and 6 replicates in cages equipped with feeders and drinking troughs. Each treatment was randomly assignedto one of the experimental feeds with variable energy levels (2600, 2800, and 3000 kcal/kg) in addition to pawpaw leaves as a staple feed. The cultured substrates were watered daily, and the animals were monitored for a period of 24 months. The results showed that the shortest ages of onset of maturity as well as the highest number of spawns per treatment were observed in snails receiving 2600 kcal/kg of energy in the feed compared to other treatments. The highest egg morphometric and fertility characteristics were found in animals fed the highest energy level of the feed. The highest protein level in the hemolymph was observed in snails given 3000 kcal/kg energy of the feed while the lowest cholesterol level was observed in animals receiving the same treatment. The highest total meat and gonad weight were observed in animals receiving 2800 kcal/kg energy in the feed compared to other treatments. The levels of dry and organic matter, protein, and fat in the ash increased with the energy level of the diet. Animals that received 2800 kcal/kg energy in the diet recorded a significantly lower calcium level in the flesh compared to the other two treatments. On the other hand, the percentage of phosphorus increased significantly with the energy level of the diet. In conclusion, the 2600 kcal/kg energy level can be retained in the feed of adult snails.
Influence of the Clinical Nursing Pathway on Nursing Outcomes and Complications of Cervical Carcinoma Patients Undergoing Chemotherapy via PICC
Authors: Tang Hongxia , Gao Li , Li Yahui
Published: October 2022

Background. Cervical Carcinoma (CC) is the second most common cause of death in women, with most patients being diagnosed at an advanced stage. The conventional treatment for CC, with a long chemotherapy treatment cycle, is less than satisfactory and will cause serious damage to the patient’s blood vessels. Objective. To analyze the impact of the clinical nursing pathway (CNP) on the incidence of complications and adverse prognosis in patients undergoing chemotherapy for CC via peripherally inserted central catheters (PICC). Materials and Methods. This study enrolled 157 CC patients who underwent PICC chemotherapy in the Shaanxi Provincial Cancer Hospital between March 2017 and April 2020 and assigned them between the two groups according to different nursing interventions. Ninety-three patients treated with CNP intervention were included in the research group (RG), and sixty-four cases treated with the routine nursing intervention were included in the control group (CG). The self-care ability and intervention satisfaction of patients were assessed using the self-care ability scale and the intervention satisfaction questionnaire, respectively, both developed by our hospital. The complication rate was observed in both cohorts, and the adverse prognosis of patients was statistically analyzed. Finally, an assessment was made on the patients’ quality of life (QOL) using the quality of life questionnaire core 30 (QLQ-C30). Results. Higher scores of self-management information, catheter nursing ability, self-care compliance, and abnormal situation management were determined in RG after the nursing intervention. RG also outperformed CG in the overall incidence rates of complications and poor prognosis. Moreover, RG presented statistically higher nursing satisfaction and QLQ-C30 scores than CG after the nursing intervention. Conclusion. CNP has a significant nursing effect on patients with CC treated with PICC chemotherapy, which can not only reduce the incidence of postchemotherapy complications but also improve patient prognosis, satisfaction, and life quality, with the value for clinical promotion.
Design of Ideological and Political Communication Path of Curriculum under the Background of Intelligent Information of New Media
Authors: Lu Han
Published: October 2022

In order to improve the effectiveness of the safe, high-quality, and efficient communication mechanism of ideological and political courses in the new media perspective, the ideological and political communication path of courses in the new media perspective based on blockchain technology is designed. Mainly through the organic combination of online communication, offline-online dynamic feedback, and offline communication, based on the blockchain structure, an online information transmission path of online ideological and political courses leading to offline and offline feedback online is formed. In this path, the new media network platform uses the method based on bad information screening to screen out bad information, obtain a relatively safe ideological and political course information and cultural source, and then spread the information. Through the optimization strategy of PBFT consensus protocol based on a C4.5 decision tree, the trust environment for the dissemination of ideological and political courses is constructed. The network load balancing channel allocation algorithm based on the maximum flow of curriculum ideological and political communication path is adopted to ensure the network fluency and realize the efficient dissemination of curriculum ideological and political information. The experimental results show that the designed path can realize information security, high quality, and efficient sharing of ideological and political courses and has good performance.
Design and Simulation of Multichannel Dynamic Measurement Control System
Authors: Shen Dawei , Pei Dongxing , Ma Tiehua
Published: October 2022

The circuit system designed in this paper uses FPGA and single-chip microcomputer as the main chips. It uses VHDL language programming and performs functional simulation and verification of the core control program through ModelSim software, and finally, a storage-type dynamic measurement and control system with one-to-multiple channels, adjustable trigger modes, and optional sampling frequency is realized. At the same time, the system is further optimized in terms of power consumption and volume. The storage measurement and control system can successfully record eight-channel dynamic voltage signals, and the relative error of the experimental results is less than 2% through the simulation trigger experiment and Hopkinson bar experiment loading.
Physiological Effects of Ferroptosis on Organ Fibrosis
Authors: Du Xiaojun , Dong Rui , Wu Yuzhang , Ni Bing
Published: October 2022

Ferroptosis is a new type of programmed cell death with unique morphological, biochemical, and genetic features. From the initial study of histomorphology to the exploration of subcellular organelles and even molecular mechanisms, a net connecting ferroptosis and fibrosis is being woven and formed. Inflammation may be the bridge between both processes. In this review, we will discuss the ferroptosis theory and process and the physiological functions of ferroptosis, followed by a description of the pathological effects and the underlying mechanisms of ferroptosis in the pathogenesis of tumorigenesis, ischemic damage, degenerative lesions, autoimmune diseases, and necroinflammation. We then focus on the role of ferroptosis in the fibrosis process in the liver, lung, kidney, heart, and other organs. Although the molecular mechanism of ferroptosis has been explored extensively in the past few years, many challenges remain to be resolved to translate this information into antifibrotic practice, which is becoming a promising new direction in the field of fibrotic disease prevention and treatment.
The Design of a Moral Education Evaluation System for College Students Based on a Deep Learning Model
Authors: Liu Tianji , Ru Bao , Zhang Yeqing
Published: October 2022

With the rapid development of deep learning, its application in the field of education has gradually attracted attention. This study introduces a deep learning-based moral education evaluation system for college students. The evaluation of the ideological and political education of college students is an important driving force to strengthen and improve the ideological and political education of college students, and its connotation is very rich. However, at present, there are many difficulties in the evaluation of ideological and political education in colleges and universities, such as narrow evaluation objectives, monotonous evaluation structures, lack of pertinence in the evaluation process, and subjective evaluation standards. The internal mechanism and external mechanism of the evaluation mechanism, the qualitative analysis and quantitative analysis of the evaluation method, the absoluteness and relativity of the evaluation standard, the dynamic and static evaluation process, and the systematic and specialized evaluation are combined to ensure the college students’ thinking the objectivity and effectiveness of political education evaluation.
College Students’ Ideological and Political In-Depth Teaching Community Based on Core Literacy Model
Authors: Yanju Feng , Chao Dong , Man Li
Published: October 2022

With the development of the times, building a learning community in ideological and political teaching has become an urgent need for teaching reform. In ideological and political teaching, the common vision of teachers and students is to carry out cooperative exploration and ultimately realize the progress and growth of common teachers and students, and implement the core of political science. Learning community in ideological and political teaching has the characteristics of group symbiosis, common value, cooperation and sharing, and democratic openness. Therefore, building a learning community in ideological and political teaching is conducive to the formation of a new teaching model of cooperative inquiry and the establishment of equality and democracy. The new teacher-student relationship can cultivate students’ higher-order thinking and promote more meaningful learning. It has been proved by practice that it is valuable to construct a learning community in the ideological and political teaching of universities. Teachers and students should change the traditional teaching concept. University political teachers should carefully prepare lessons, set up teaching design, be considerate to students, be close to reality, be close to knowledge itself, enhance the communication and interaction between teachers and students, and students and students, and actively build a learning community in the process of ideological and political teaching. To enable students to get new knowledge, solve challenging problems, and finally achieve progress and growth.
In-Vitro Leishmanicidal Activity and Molecular Docking Simulations of a Flavonoid Isolated from Pistacia integerrima Stew ex Brandis
Authors: Hemeg Hassan A. , Rauf Abdur , Rashid Umer , Muhammad Naveed , Al-Awthan Yahya S. , Bahattab Omar S. , Al-Duais Mohammed A. , Uzair Ali Shah Syed , Sharma Rohit
Published: October 2022

Pistacia integerrima Stew ex Brandis is a valued medicinal plant used for curing various diseases such as diarrhea, fever, liver disorder, pain, asthma, and inflammation. The aim of this study was the isolation of bioactive leishmanicidal agents from the methanolic extract. The methanolic extract led to the isolation of flavonoids 3,5,7,4/-tetrahydroxy-flavanone (1). The extract and isolated compound 1 were tested for antileishmanial effect. The extract showed a percent effect of 63.09 with an IC50 value (49.32 µM). The isolated compound 1 was more leishmanicidal than the extract with a percent growth inhibition of 68.09. We have performed docking studies on two antileishmanial targets; homology modeled dihydrofolate reductase (DHFR) and pteridine reductase (PTR1) from Leishmania major (L. major). Interaction with important residues of the studied enzymes revealed the possible mechanism of in-vitro activity against promastigotes of L. major.
Stachys pilifera Benth. Ameliorates Bleomycin-Induced Pulmonary Fibrosis in Rats through the Antioxidant Pathways
Authors: Danaei Nazanin , Panahi kokhdan Esmaeel , Sadeghi Hossein , Sadeghi Heibatollah , Hassanzadeh Sajad , Rostamzadeh Davoud , Azarmehr Nahid , Hafez Ghoran Salar
Published: October 2022

Background and Aim. Fibrosis of the lungs is an interstitial lung disease whose diagnosis and treatment are not well-established. Stachys pilifera Benth. (Lamiaceae) has been proven to have antioxidant and anti-inflammatory properties. This study was performed to determine the effect of S. pilifera extract on bleomycin-induced pulmonary fibrosis in rats. Methods. In this experimental study, 35 male Wistar rats (120–180 g) were divided into five groups (n = 7) as follows: intratracheal instillation of bleomycin (BLM, 7.5 IU/kg) was administered to group II. The third and fourth groups received BLM plus Stachys pilifera hydroalcoholic extract (SPHE) (300 mg/kg/day, gavage). Vitamin E (500 mg/kg/day, gavage) was given to group V in addition to BLM. After 14 days, the animals were euthanized to assess biochemical parameters and lung histopathology. Malondialdehyde (MDA), nitric oxide (NO), total thiol (TSH), and glutathione (GSH) levels were measured. In addition, hydroxyproline (HYP) levels along with histological changes in lung tissue were also assessed. Results. MDA, NO, and HYP elevations induced by BLM toxicity were significantly inhibited by SPHE (300 and 600 mg/kg), and Vit E. SPHE also significantly increased GSH and TSH levels in comparison to the BLM group.HPLC analyses showed the presence of thymol (55.47 ng/mL) and carvacrol (109.91 ng/mL) in SPHE as potential bioactive phenolic compounds. Conclusion. The results suggest that SPHE alleviates the development of BLM-induced pulmonary fibrosis by inhibiting the proliferation of fibroblasts mediated by antioxidant pathways. Other mechanisms underlying this Effect of SPHE need to be clarified through further research.