bluuebunny/crossref_metadata_2025 huggingface dataset:
Wide-field retinotopy reveals a new visuotopic cluster in macaque posterior parietal cortex
Authors: Rima Samy , Cottereau Benoit R. , Héjja-Brichard Yseut , Trotter Yves , Durand Jean-Baptiste
Published: September 2020

We investigated the visuotopic organization of macaque posterior parietal cortex (PPC) by combining functional imaging (fMRI) and wide-field retinotopic mapping in two macaque monkeys. Whole brain blood-oxygen-level-dependent (BOLD) signal was recorded while monkeys maintained central fixation during the presentation of large rotating wedges and expending/contracting annulus of a “shaking” fruit basket, designed to maximize the recruitment of PPC neurons. Results of the surface-based population receptive field (pRF) analysis reveal a new cluster of four visuotopic areas at the confluence of the parieto-occipital and intra-parietal sulci, in a location previously defined histologically and anatomically as the posterior intra-parietal (PIP) region. This PIP cluster groups together two recently described areas (CIP1/2) laterally and two newly identified ones (PIP1/2) medially, whose foveal representations merge in the fundus of the intra-parietal sulcus. The cluster shares borders with other visuotopic areas: V3d posteriorly, V3A/DP laterally, V6/V6A medially and LIP anteriorly. Together, these results show that monkey PPC is endowed with a dense set of visuotopic areas, as its human counterpart. The fact that fMRI and wide-field stimulation allows a functional parsing of monkey PPC offers a new framework for studying functional homologies with human PPC.
Bacterial aggregate size determines phagocytosis efficiency of polymorphonuclear leukocytes
Authors: Alhede Maria , Lorenz Melanie , Fritz Blaine Gabriel , Jensen Peter Østrup , Ring Hans Christian , Bay Lene , Bjarnsholt Thomas
Published: September 2020

The ability of bacteria to aggregate and form biofilms impairs phagocytosis by polymorphonuclear leukocytes (PMNs). The aim of this study was to examine if the size of aggregates is critical for successful phagocytosis and how bacterial biofilms evade phagocytosis. We investigated the live interaction between PMNs andPseudomonas aeruginosa,Staphylococcus aureus,Escherichia coliandStaphylococcus epidermidisusing confocal scanning laser microscopy. Aggregate size significantly affected phagocytosis outcome and larger aggregates were less likely to be phagocytized. Aggregates ofS. epidermidiswere also less likely to be phagocytized than equally-sized aggregates of the other three species. We found that only aggregates of approx. 5 μm diameter or smaller were consistently phagocytosed. We demonstrate that planktonic and aggregated cells of all four species significantly reduced the viability of PMNs after 4 h of incubation. Our results indicate that larger bacterial aggregates are less likely to be phagocytosed by PMNs and we propose that, if the aggregates become too large, circulating PMNs may not be able to phagocytose them quickly enough, which may lead to chronic infection.
A computational phase transformation model for selective laser melting processes
Authors: Noll Isabelle , Bartel Thorsten , Menzel Andreas
Published: September 2020

Selective laser melting (SLM) has gained large interest due to advanced manufacturing possibilities. However, the growing potential also necessitates reliable predictions of structures in particular regarding their long-term behaviour. The constitutive and structural response is thereby challenging to reproduce, due to the complex material behaviour. This motivates the aims of this contribution: To establish a material model that accounts for the behaviour of the different phases occurring during SLM but that still allows the use of (basic) process simulations. In particular, the present modelling framework explicitly takes into account the mass fractions of the different phases, their mass densities, and specific inelastic strain contributions. The thermomechanically fully coupled framework is implemented into the software Abaqus. The numerical examples emphasise the capabilities of the framework to predict, e.g., the residual stresses occurring in the final part. Furthermore, a postprocessing of averaged inelastic strains is presented yielding a micromechanics-based motivation for inherent strains.
Patient competence in the context of cancer: its dimensions and their relationships with coping, coping self-efficacy, fear of progression, and depression
Authors: Giesler Jürgen M. , Weis Joachim
Published: September 2020

Purpose

Influenced in part by research on coping, patient empowerment and self-efficacy, and by patient self-help initiatives, the construct of patient competencies (PC) has been elaborated and later integrated into Germany’s National Cancer Plan. As a self-report measure of PC, the Patient Competence Questionnaire 57 (PCQ-57) has only rarely been evaluated psychometrically. Therefore, we aimed to re-examine its dimensionality and its relationships with related constructs and potential psychosocial cancer outcomes.

Methods

We surveyed 424 breast, colorectal, and prostate cancer patients from clinics for oncological rehabilitation and private oncology practices who completed the PCQ-57 and self-report measures of coping, coping self-efficacy, fear of progression, and depression. Patients’ PCQ-57 responses were submitted to principal axis factor analyses. Using the original scoring keys, we computed internal consistencies (Cronbach’s α) and Pearson correlations between all measures.

Results

Factor analyses suggested 5 of the 8 original PCQ-57 dimensions to replicate satisfactorily, their internal consistencies ranging from 0.74 to 0.88. The competency of managing distress correlated significantly, highly, and negatively with fear of progression and depression (|r’s| ≥ 0.43) and positively with coping self-efficacy (r = 0.58).

Conclusion

The results support the reliability and validity of 5 of the 8 original PCQ-57 scales while suggesting refinement of the others. The replicated scales may help identify patients in need of support for dealing with the multiple tasks of adjusting to cancer. Further research should clarify the conceptual and empirical relationships between PC, health literacy, and patient activation as well as potential effects of PC on psychosocial cancer outcomes.
Ultrasound-assisted dispersive micro-solid phase extraction using molybdenum disulfide supported on reduced graphene oxide for energy dispersive X-ray fluorescence spectrometric determination of chromium species in water
Authors: Pytlakowska Katarzyna , Kocot Karina , Pilch Michał , Zubko Maciej
Published: September 2020

Molybdenum disulfide (MoS2) was supported on graphene oxide (GO) by hydrothermal method. The resulting nanocomposite (MoS2-rGO) was characterized by X-ray photoelectron spectroscopy, scanning electron microscopy, and transmission electron microscopy. The experiments show that at pH 2, MoS2-rGO has a great affinity for adsorption of hexavalent chromium ions while Cr(III) ions remain in aqueous sample. In the adsorption process, the dominant role plays chemisorption. The determined adsorption capacity is 583.5 mg g−1. Parameters affecting the extraction process, namely sample pH, sample volume, contact time, and matrix ions, were investigated by sequential batch tests. Under optimal conditions (pH 2, sample volume 50 mL, sonication time 10 min, adsorbent mass 1 mg), the calibration curve covers the 1–200 ng mL−1 range with a correlation coefficient (R2) of 0.998. The recovery of the method is 97 ± 3%. Other data of merit include a relative standard deviation of < 3.5%, enrichment factor of 3350, and detection limit of 0.050 ng mL−1. The accuracy of the method was confirmed by analysis of the reference materials QC1453 (chromium VI in drinking water) and QC3015 (chromium VI in seawater). The method was successfully applied to chromium speciation in water samples, including high salinity ones. The concentration of Cr(III) was calculated as the difference between the total concentration of chromium (after oxidation of Cr(III) to Cr(VI) with potassium permanganate) and the initial Cr(VI) content.

Graphical abstract
Anesthetics and plants: no pain, no brain, and therefore no consciousness
Authors: Draguhn Andreas , Mallatt Jon M. , Robinson David G.
Published: September 2020

Plants have a rich variety of interactions with their environment, including adaptive responses mediated by electrical signaling. This has prompted claims that information processing in plants is similar to that in animals and, hence, that plants are conscious, intelligent organisms. In several recent reports, the facts that general anesthetics cause plants to lose their sensory responses and behaviors have been taken as support for such beliefs. These lipophilic substances, however, alter multiple molecular, cellular, and systemic functions in almost every organism. In humans and other animals with complex brains, they eliminate the experience of pain and disrupt consciousness. The question therefore arises: do plants feel pain and have consciousness? In this review, we discuss what can be learned from the effects of anesthetics in plants. For this, we describe the mechanisms and structural prerequisites for pain sensations in animals and show that plants lack the neural anatomy and all behaviors that would indicate pain. By explaining the ubiquitous and diverse effects of anesthetics, we discuss whether these substances provide any empirical or logical evidence for “plant consciousness” and whether it makes sense to study the effects of anesthetics on plants for this purpose. In both cases, the answer is a resounding no.
Grundwasser in ehemaligen deutschen Steinkohlenrevieren – ein wissenschaftlicher Blickwinkel auf Grubenflutungen
Authors: Kessler Timo , Mugova Elke , Jasnowski-Peters Henning , Rinder Thomas , Stemke Marion , Wolkersdorfer Christian , Hilberg Sylke , Melchers Christian , Struckmeier Wilhelm , Wieber Georg , Schafmeister Maria-Th.
Published: September 2020

Zum Ende des Jahres 2018 wurde in Deutschland der Steinkohlenbergbau eingestellt. Damit beginnt auch in den bis zuletzt aktiven Revieren die Phase des Nachbergbaus inklusive einer dauerhaften Wasserhaltung. Diese beinhaltet typischerweise eine teilweise Grubenflutung und die Ableitung von Grubenwasser in nahegelegene Vorfluter. Im Blickpunkt der öffentlichen und wissenschaftlichen Diskussion stehen bergbauliche Schadstoffquellen und deren Risiken für die oberflächennahen Trinkwasserressourcen. Es existieren eine Reihe Kriterien und Kontrollmechanismen, um potenziellen Schadstoffaustrag zu erkennen und zu verhindern. Dazu zählen moderne Monitoringprogramme und Modellanwendungen, welche bestehende Schadstoffprognosen verbessern können. Daneben ist auch eine rechtlich und fachlich begründete Bewertung von Gefahrenszenarios eine entscheidende Größe für nachhaltiges Risikomanagement. Der Grubenwasseranstieg eröffnet jedoch auch Chancen, ehemalige Bergwerke für energetische Nutzungen umzurüsten. Bereits heute werden Heizkraftwerke mit Grubenwasser betrieben und es besteht großes Ausbaupotenzial. Dieser Beitrag diskutiert die Chancen und Risiken von Grubenflutungen in Deutschland und gibt einen Ausblick, welche Entwicklungen und Herausforderungen in Zukunft zu erwarten sind.
A prospective clinical pilot study on the effects of a hydrogen peroxide mouthrinse on the intraoral viral load of SARS-CoV-2
Authors: Gottsauner Maximilian J. , Michaelides Ioannis , Schmidt Barbara , Scholz Konstantin J. , Buchalla Wolfgang , Widbiller Matthias , Hitzenbichler Florian , Ettl Tobias , Reichert Torsten E. , Bohr Christopher , Vielsmeier Veronika , Cieplik Fabian
Published: September 2020

Objectives

SARS-CoV-2 is mainly transmitted by inhalation of droplets and aerosols. This puts healthcare professionals from specialties with close patient contact at high risk of nosocomial infections with SARS-CoV-2. In this context, preprocedural mouthrinses with hydrogen peroxide have been recommended before conducting intraoral procedures. Therefore, the aim of this study was to investigate the effects of a 1% hydrogen peroxide mouthrinse on reducing the intraoral SARS-CoV-2 load.

Methods

Twelve out of 98 initially screened hospitalized SARS-CoV-2-positive patients were included in this study. Intraoral viral load was determined by RT-PCR at baseline, whereupon patients had to gargle mouth and throat with 20 mL of 1% hydrogen peroxide for 30 s. After 30 min, a second examination of intraoral viral load was performed by RT-PCR. Furthermore, virus culture was performed for specimens exhibiting viral load of at least 103 RNA copies/mL at baseline.

Results

Ten out of the 12 initially included SARS-CoV-2-positive patients completed the study. The hydrogen peroxide mouthrinse led to no significant reduction of intraoral viral load. Replicating virus could only be determined from one baseline specimen.

Conclusion

A 1% hydrogen peroxide mouthrinse does not reduce the intraoral viral load in SARS-CoV-2-positive subjects. However, virus culture did not yield any indication on the effects of the mouthrinse on the infectivity of the detected RNA copies.

Clinical relevance

The recommendation of a preprocedural mouthrinse with hydrogen peroxide before intraoral procedures is questionable and thus should not be supported any longer, but strict infection prevention regimens are of paramount importance.

Trial registration

German Clinical Trials Register (ref. DRKS00022484)
Active Force Generation in Cardiac Muscle Cells: Mathematical Modeling and Numerical Simulation of the Actin-Myosin Interaction
Authors: Regazzoni Francesco , Dedè Luca , Quarteroni Alfio
Published: September 2020

Cardiac in silico numerical simulations are based on mathematical models describing the physical processes involved in the heart function. In this review paper, we critically survey biophysically-detailed mathematical models describing the subcellular mechanisms behind the generation of active force, that is the process by which the chemical energy of ATP (adenosine triphosphate) is transformed into mechanical work, thus making the muscle tissue contract. While presenting these models, that feature different levels of biophysical detail, we analyze the trade-off between the accuracy in the description of the subcellular mechanisms and the number of parameters that need to be estimated from experiments. Then, we focus on a generalized version of the classic Huxley model, built on the basis of models available in the literature, that is able to reproduce the main experimental characterizations associated to the time scales typical of a heartbeat—such as the force-velocity relationship and the tissue stiffness in response to small steps—featuring only four independent parameters. Finally, we show how those parameters can be calibrated starting from macroscopic measurements available from experiments.
On the possibility of getting traceable time and frequency measurements via GNSS receivers
Authors: Bauch Andreas , Piester Dirk , Polewka Thomas , Staliuniene Egle
Published: September 2020

The realization of Coordinated Universal Time, one of the tasks of the International Bureau of Weights and Measures, relies on a network of international time links which currently is organized in a star-like scheme that links all contributing laboratories. GPS signal reception is the technique most widely employed by the laboratories. The PTB currently plays a unique role in the process due to its function as the central pivot in the time transfer between the participating laboratories. We discuss how the PTB meets its obligations to the international timekeeping community as well as to its users in Germany. In its role as an National Metrology Institute (NMI), PTB is entrusted with the realization and dissemination of legal time in Germany. The services were offered to the public support measurements and timing applications traceable to the national and international standards to be made in calibration laboratories and in many industrial sectors. We thus discuss the meaning and definition of traceability, how different GNSS systems can be used to establish traceability and their performance in doing so.
Multiplex gene editing and large DNA fragment deletion by the CRISPR/Cpf1-RecE/T system in Corynebacterium glutamicum
Authors: Zhao Nannan , Li Lu , Luo Guangjuan , Xie Shan , Lin Ying , Han Shuangyan , Huang Yuanyuan , Zheng Suiping
Published: September 2020

Corynebacterium glutamicum is an essential industrial strain that has been widely harnessed for the production of all kinds of value-added products. Efficient multiplex gene editing and large DNA fragment deletion are essential strategies for industrial biotechnological research. Cpf1 is a robust and simple genome editing tool for simultaneous editing of multiplex genes. However, no studies on effective multiplex gene editing and large DNA fragment deletion by the CRISPR/Cpf1 system in C. glutamicum have been reported. Here, we developed a multiplex gene editing method by optimizing the CRISPR/Cpf1-RecT system and a large chromosomal fragment deletion strategy using the CRISPR/Cpf1-RecET system in C. glutamicum ATCC 14067. The CRISPR/Cpf1-RecT system exhibited a precise editing efficiency of more than 91.6% with the PAM sequences TTTC, TTTG, GTTG or CTTC. The sites that could be edited were limited due to the PAM region and the 1–7 nt at the 5′ end of the protospacer region. Mutations in the PAM region increased the editing efficiency of the − 6 nt region from 0 to 96.7%. Using a crRNA array, two and three genes could be simultaneously edited in one step via the CRISPR/Cpf1-RecT system, and the efficiency of simultaneously editing two genes was 91.6%, but the efficiency of simultaneously editing three genes was below 10%. The editing efficiency for a deletion of 1 kb was 79.6%, and the editing efficiencies for 5- and 20 kb length DNA fragment deletions reached 91.3% and 36.4%, respectively, via the CRISPR/Cpf1-RecET system. This research provides an efficient and simple tool for C. glutamicum genome editing that can further accelerate metabolic engineering efforts and genome evolution.
Landslide detection by deep learning of non-nadiral and crowdsourced optical images
Authors: Catani Filippo
Published: September 2020

The recent development of mobile surveying platforms and crowdsourced geoinformation has produced a huge amount of non-validated data that are now available for research and application. In the field of risk analysis, with particular reference to landslide hazard, images generated by autonomous platforms (such as UAVs, ground-based acquisition systems, satellite sensors) and pictures obtained from web data mining are easily gathered and contribute to the fast surge in the amount of non-organized information that may engulf data storage facilities. Therefore, the high potential impact of such methods is severely reduced by the need of a massive amount of human intelligence tasks (HITs), which is necessary to filter and classify the data, whatever the final purpose. In this work, we present a new set of convolutional neural networks (CNNs) specifically designed for the automated recognition of landslides and mass movements in non-standard pictures that can be used in automated image classification, in supporting UAV autonomous guidance and in the filtering of data-mined information. Computer vision can be of great help in fostering the autonomous capability of intelligent systems to complement, or completely substitute, HITs. Image and object recognition are at the forefront of this research field. The deep learning procedure has been accomplished by applying transfer learning to some of the top-performer CNNs available in the literature. Results show that the deep learning machines, calibrated on a relevant dataset of validated images of landforms, may supply reliable predictions with computational time and resource requirements compatible with most of the UAV platforms and web data mining applications in landslide hazard studies. Average accuracy achieved by the proposed methods ranges between 87 and 90% and is consistently higher than that obtained by general-purpose state-of-the-art image recognition convolutional neural networks. The method can be applied to early warning, vulnerability assessment, residual risk estimation, model parameterisation and landslide mapping. Specific advantages will be the reduction of the present limitations in the intelligent guidance of landslide mapping drones, the classification of fake news, the validation of post-disaster information and the correct interpretation of an impending change in the environment.
Epidemiology and Molecular Characterization of Rotavirus A in Fruit Bats in Bangladesh
Authors: Islam Ariful , Hossain Mohammad Enayet , Rostal Melinda K. , Ferdous Jinnat , Islam Ausraful , Hasan Rashedul , Miah Mojnu , Rahman Mustafizur , Rahman Mohammed Ziaur , Daszak Peter , Epstein Jonathan H.
Published: September 2020

Rotavirus A (RVA) is the primary cause of acute dehydrating diarrhea in human and numerous animal species. Animal-to-human interspecies transmission is one of the evolutionary mechanisms driving rotavirus strain diversity in humans. We screened fresh feces from 416 bats (201 Pteropus medius, 165 Rousettus leschenaultii and 50 Taphozous melanopogon) for RVA using rRT-PCR. We detected a prevalence of 7% (95% CI 3.5–10.8) and 2% (95% CI 0.4–5.2) in P. medius and R. leschenaultii, respectively. We did not detect RVA in the insectivorous bat (T. melanopogon). We identified RVA strains similar to the human strains of G1 and G8 based on sequence-based genotyping, which underscores the importance of including wildlife species in surveillance for zoonotic pathogens to understand pathogen transmission and evolution better.
Covid-19 and Crisis-Prompted Distance Education in Sweden
Authors: Bergdahl Nina , Nouri Jalal
Published: September 2020

This study represents the first research effort to explore the transition from traditional teaching into distance teaching in Swedish schools enforced by covid-19. Governments made gradual and injudicious decisions to impede the spread of the pandemic (covid-19) in 2020. The enactment of new measures affected critical societal functions and included travel restrictions, closing of borders, school closures and lockdowns of entire countries worldwide. Social distancing became the new reality for many, and for many teachers and students, the school closure prompted a rapid transition from traditional to distance education. This study aims to capture the early stages of that transition. We distributed a questionnaire to teachers’ (n = 153) to gain insights into teacher and school preparedness, plans to deliver distance education, and teachers’ experience when making this transition. Results show that the school preparedness was mainly related to technical aspects, and that teachers lack pedagogical strategies needed in the emerging learning landscape of distance education. Findings reveal four distinct pedagogical activities central for distance education in a crisis, and many challenges faced during the transition. While preparedness to ensure continuity of education was halting, schools and teachers worked with tremendous effort to overcome the challenges. Results expand on previous findings on school closure during virus outbreaks and may in the short-term support teachers and school leaders in making informed decisions during the shift into distance education. The study may also inform the development of preparedness plans for schools, and offers a historical documentation.
Effects of Basicity and Al2O3 Content on the Chemistry of Phases in Iron Ore Sinter Containing ZnO
Authors: Park Junwoo , Rajavaram Ramaraghavulu , Suh In-Kook , Jeon Jiwon , Son Sanghan , Lee Joonho
Published: September 2020

The effects of basicity and Al2O3 content on the chemistry of phases in iron ore sinter containing ZnO were investigated by Rietveld analysis of the X-ray diffraction (XRD) patterns. Bulk composition analysis was carried out using inductively coupled plasma-atomic emission spectroscopy (ICP-AES) and wet-chemical analysis. The composition of each phase was investigated using a scanning electron microscope-energy dispersive X-ray analyzer (SEM-EDX). It was found that ZnO exists in the franklinite and the silicoferrite of calcium and aluminum (SFCA) phases. With increasing ZnO content, the phase fraction of the franklinite increased, while the fraction of SFCA slightly increased. When ZnO content was fixed at 1 wt pct and basicity increased, the fraction of franklinite decreased and that of SFCA increased. Here, the solubility of ZnO in the SFCA increased. As the Al2O3 content increased, the fraction of franklinite decreased and that of SFCA increased, while ZnO content in the SFCA did not change significantly.
A Comparative Study of Different Administrations of Nebulized Hyaluronic Acid After Endoscopic Endonasal Surgery for Chronic Rhinosinusitis
Authors: Abbate Vincenzo , Iaconetta Giorgio , Maglitto Fabio , Improta Giovanni , Romano Antonio , Bonavolontà Paola , Seidita Francesco , Califano Luigi , Dell’Aversana Orabona Giovanni
Published: September 2020

Hyaluronic Acid (HA) plays many roles in wound healing in general, through different mechanisms. Several authors reported the effectiveness of hyaluronic acid in promoting mucosal healing and reducing discomfort for patients after endoscopic sinus surgery (ESS). Different methods for HA nasal administration have been reported. The aim of our study has been to evaluate the efficacy of the administration of nebulized HA through a nasal douche compared with its administration through a nasal spray with patients undergoing ESS for chronic rhinosinusitis. From January 2013 to January 2019 a prospective clinical trial was carried out in our hospital with 163 patients who had undergone ESS for chronic rhinosinusitis. The sample was divided into three groups according to the method of administration of HA. Our study confirm the efficacy of the administration of nebulized HA through nasal douche in post-operative care (6.5% vs 4.5%). The most relevant data regards the nasal dryness sign: the data revealed an unexpected percentage of worsening of that sign at time T3 (p = 0.049) particularly evident in the patients treated with HA through nasal douche compared to whom the nasal spray device was prescribed (4% vs 1%). Further studies are needed to identify the best means of administration of HA, which would satisfy the requirements for efficacy in terms of the results and, at the same time, patient compliance.
Reproductive decision-making in the context of hereditary cancer: the effects of an online decision aid on informed decision-making
Authors: Reumkens Kelly , Tummers Marly H. E. , Severijns Yil , Gietel-Habets Joyce J. G. , van Kuijk Sander M. J. , Aalfs Cora M. , van Asperen Christi J. , Ausems Margreet G. E. M. , Collée Margriet , Dommering Charlotte J. , Kets Marleen , van der Kolk Lizet E. , Oosterwijk Jan C. , Tjan-Heijnen Vivianne C. G. , van der Weijden Trudy , de Die-Smulders Christine E. M. , van Osch Liesbeth A. D. M.
Published: September 2020

Individuals having a genetic predisposition to cancer and their partners face challenging decisions regarding their wish to have children. This study aimed to determine the effects of an online decision aid to support couples in making an informed decision regarding their reproductive options. A nationwide pretest-posttest study was conducted in the Netherlands among 131 participants between November 2016 and May 2018. Couples were eligible for participation if one partner had a pathogenic variant predisposing for an autosomal dominant hereditary cancer syndrome. Participants completed a questionnaire before use (T0), and at 3 months (T3) after use of the decision aid to assess the primary outcome measure informed decision-making, and the secondary outcome measures decisional conflict, knowledge, realistic expectations, level of deliberation, and decision self-efficacy. T0–T3 comparisons show an overall positive effect for all outcome measures (allps < 0.05; knowledge (ES = − 1.05), decisional conflict (ES = 0.99), participants’ decision self-efficacy (ES = −0.55), level of deliberation (ES = − 0.50), and realistic expectations (ES = − 0.44). Informed decision-making increased over time and 58.0% of the participants made an informed reproductive decision at T3. The online decision aid seems to be an appropriate tool to complement standard reproductive counseling to support our target group in making an informed reproductive decision. Use of the decision aid may lessen the negative psychological impact of decision-making on couples’ daily life and wellbeing.
The Italian mobile surgical units in the Great War: the modernity of the past
Authors: Vergani Contardo , Venturi Marco
Published: September 2020

Medical services in WWI had to face enormous new problems: masses of wounded, most with devastating wounds from artillery splinters, often involving body cavities, and always contaminated. Tetanus, gas gangrene, wound infections were common and often fatal. Abdominal wounds were especially a problem: upon entering the war the commanders of all medical services ordered to avoid surgery, based on dismal experiences of previous wars. Surgical community divided into non-operative and operative treatment supporters. The problem seemed mainly organizational, as the wounded were rescued after many hours and treated by non-specialist doctors, in inadequate frontline settings or evacuated back with further delay of treatment. During initial neutrality, Italian Academics closely followed the debate, with different positions. Many courses and publications on war surgery flourished. Among the interventionists, Baldo Rossi, to provide a setting adequate to major operations close to the frontline, with trained surgeons and adequate instruments, realized for the Milano Red Cross three fully equipped, mobile surgical hospitals mounted on trucks, with an operating cabin-tent, with warming, illumination and sterilizing devices, post-operative tents and a radiological unit. Chiefs of the army approved the project and implemented seven similar units, called army surgical ambulances, each run by a distinguished surgeon. Epic history and challenges of the mobile units at the frontline, brilliant results achieved on war wounds and epidemics are described. After the war they were considered among the most significant novelties of military medical services. Parallels with present scenarios in war and peace are outlined.
Elastic-plastic-brittle transitions of potassium dihydrogen phosphate crystals: characterization by nanoindentation
Authors: Zhang Yong , Hou Ning , Zhang Liang-Chi , Wang Qi
Published: September 2020

Potassium dihydrogen phosphate (KDP) crystals are widely used in laser ignition facilities as optical switching and frequency conversion components. These crystals are soft, brittle, and sensitive to external conditions (e.g., humidity, temperature, and applied stress). Hence, conventional characterization methods, such as transmission electron microscopy, cannot be used to study the mechanisms of material deformation. Nevertheless, understanding the mechanism of plastic-brittle transition in KDP crystals is important to prevent the fracture damage during the machining process. This study explores the plastic deformation and brittle fracture mechanisms of KDP crystals through nanoindentation experiments and theoretical calculations. The results show that dislocation nucleation and propagation are the main mechanisms of plastic deformation in KDP crystals, and dislocation pileup leads to brittle fracture during nanoindentation. Nanoindentation experiments using various indenters indicate that the external stress fields influence the plastic deformation of KDP crystals, and plastic deformation and brittle fracture are related to the material’s anisotropy. However, the effect of loading rate on the KDP crystal deformation is practically negligible. The results of this research provide important information on reducing machining-induced damage and further improving the optical performance of KDP crystal components.
Diagnosis and Management of Fetal Ductus Arteriosus Constriction
Authors: Chugh Bindiya D. , Makam Adinarayana
Published: September 2020

The ductus arteriosus is an important structure in the fetal circulation. It connects the pulmonary artery to the arch of the aorta distal to the origin of the left subclavian artery and carries most of the right ventricular output. Patency of the ductus arteriosus is maintained by factors like prostaglandin E2, nitric oxide and low oxygen tension of the blood. With the advent of ultrasonography and Spectral Doppler, many cases of ductal constriction have been reported. It can be idiopathic but is usually secondary to the use of medication like NSAIDs, isoxsuprine, fluoxetine and also some particular foods rich in polyphenol like herbal teas, dark chocolate, berries and coffee. Idiopathic ductal constriction is a rare finding. Ductus arteriosus constriction occurs largely due to inhibition of the prostaglandin synthetase pathway as the ductus arteriosus becomes more sensitive to prostaglandin inhibitors in later gestation. It is, therefore, more commonly seen in the 3rd trimester. Because of fetal hyperdynamic compromise, it results in tricuspid regurgitation, right ventricular hypertrophy and ultimately right ventricular failure, hydrops, pulmonary hypertension and even intrauterine fetal death. We present a series of ductus arteriosus constriction, of which 3 cases were associated with tricuspid regurgitation, 1 case with right sided dominance of the heart and 1 case with moderate to severe right ventricular hypertrophy. Mild cases require close fetal monitoring and severe cases may need urgent delivery. Postnatal prognosis seems to be good in cases of ductal constriction associated with right heart abnormalities as right heart abnormalities resolve in a couple of weeks, although pulmonary hypertension and right ventricular failure are major concerns. Preventive measures include avoiding the use of NSAIDs and other medications especially in the 3rd trimester and changes in maternal dietary habits.
Amiodaron-induzierte Thyreopathien
Authors: Trummer Christian , Theiler-Schwetz Verena , Pilz Stefan
Published: September 2020

Amiodaron ist ein Klasse III-Antiarrhythmikum mit einem breiten Spektrum von Wirkungen auf die Schilddrüse, wodurch sowohl eine Schilddrüsenunterfunktion als auch eine Schilddrüsenüberfunktion entstehen kann. Dies ist zum einen durch den sehr hohen Jodgehalt von Amiodaron und zum anderen durch das mögliche Auslösen einer destruktiven Thyreoiditis zu erklären. Eine Amiodaron-induzierte Hypothyreose (AIH) wird wie auch sonst üblich mit Levothyroxin behandelt, ein Absetzen von Amiodaron ist deshalb nicht notwendig. Bei der Amiodaron-induzierten Thyreotoxikose (AIT) werden zwei Formen unterschieden: Die AIT 1 entsteht durch den Jodexzess bei Amiodarontherapie auf dem Boden eines Morbus Basedow oder einer Schilddrüsenautonomie, die AIT 2 stellt eine destruktive Thyreoiditis dar. Diese Unterscheidung ist bei der Diagnostik von großer Bedeutung, da je nach Subtyp eine unterschiedliche Erstlinientherapie begonnen wird. Die AIT 1 wird zunächst mit Thionamiden (± Natriumperchlorat) behandelt, PatientInnen mit AIT 2 erhalten zu Beginn Glukokortikoide. Falls eine genaue Einteilung in einen der beiden Subtypen nicht möglich ist (Mischtypen/undefinierte Typen), kann zunächst das Ansprechen auf Thionamide getestet werden oder von Beginn an eine Kombinationstherapie mit Glukokortikoiden erfolgen. Amiodaron muss insbesondere bei milden Fällen einer AIT 2 nicht abgesetzt werden, bei AIT 1 sollte ein Absetzen erwogen werden. In Notfällen sowie bei kritisch kranken PatientInnen kann auch eine Thyreoidektomie erfolgen.
A Multi-layered Psychological-Based Reference Model for Citizen Need Assessment Using AI-Powered Models
Authors: Alharthi Rajwa , El Saddik Abdulmotaleb
Published: September 2020

We propose an automatic, low-cost, large-scale, nonintrusive human need recognition framework that utilized a multi-layered psychological-based reference model and designed with different modules including data collection, preprocessing, feature extraction and contextualization module. The reference model comprises several classification and regression models to identify human psychological needs, measure their satisfaction levels, evaluate their surrounding environment around different life aspects during any subjective event or towards emerging topics at any time, and in any location, using their publicly available social media content. We evaluate the predictive powers of various textual, psychological, semantic, lexicon-based and Twitter-specific features. To provide benchmark results, we compare and evaluate the performance of diverse machine learning algorithms. Our results confirm the effectiveness of the developed reference model. The framework is used to recognize citizen needs in response to the New Zealand terror attacks which occurred on March 15th, 2019.
Web Conferencing Facilitation Within Problem-Based Learning Biomedical Engineering Courses
Authors: Arena Sara L. , Lee Yong W. , Verbridge Scott S. , Muelenaer Andre , VandeVord Pamela J. , Arena Christopher B.
Published: September 2020

Problem-based learning (PBL) has been effectively used within BME education, though there are several challenges in its implementation within courses with larger enrollments. Furthermore, the sudden transition to online learning from the COVID-19 pandemic introduced additional challenges in creating a similar PBL experience in an online environment. Online constrained PBL was implemented through asynchronous modules and synchronous web conferencing with rotating facilitators. Overall, facilitators perceived web conferencing facilitation to be similar to in-person, but noted that students were more easily “hidden” or distracted. Students did not comment on web conferencing facilitation specifically, but indicated the transition to online PBL was smooth. Course instructors identified that a fully synchronous delivery as well as modifications of Group Meeting Minutes assignments as potential modifications for future offerings. Future work will aim to address the perceptions and effectiveness of web conferencing facilitation for PBL courses within an undergraduate BME curriculum, as web conferencing could prove to be another significant breakthrough in addressing challenges of problem-based learning courses.
Unwanted Attention: Swiss Multinationals and the Creation of International Corporate Guidelines in the 1970s
Authors: Pitteloud Sabine
Published: September 2020

During the last decade, we have seen an increased opposition to globalization. Within this wave of criticism, firms and more specifically multinational corporations have been major targets, accused of multiple wrongdoings, such as social dumping, fiscal evasion, job cuts, trade deficits, abuses of power, and environmental damages. In many respects, this debate echoes the one that took place during the 1970s with respect to oil shocks, de-industrialization, and imperialism. At that time, several international organizations, such as the OECD, ECOSOC, ILO, and the European Community started to address the issue of multinationals and international investments, and advocated for the creation of guidelines to regulate their activities. The following paper explores the reactions of Swiss multinationals to these attempts, as well as their strategies for protecting their latitude in conducting business. Relying on archival material of the Swiss Union of Commerce and Industry and of the Federal Archives, this paper shows how the biggest companies in the pharmaceutical, machine, and food processing industries—all of them still being global players —decided to create a task force to deal with these emerging regulations at the international level.
Reactivity to Sustainability Metrics: A Configurational Study of Motivation and Capacity
Authors: Slager Rieneke , Gond Jean-Pascal , Crilly Donal
Published: September 2020

Previous research on reactivity—defined as changing organizational behaviour to better conform to the criteria of measurement in response to being measured—has found significant variation in company responses toward sustainability metrics. We propose that reactivity is driven by dialogue, motivation, and capacity in a configurational way. Empirically, we use fuzzy set qualitative comparative analysis to analyze company responses to the sustainability index FTSE4Good. We find evidence of complementary and substitute effects between motivation and capacity. Based on these effects, we develop a typology of reactivity to sustainability metrics, which also theorizes the use of metrics as tools for performance feedback and the building of calculative capacity. We show that when reactivity is studied configurationally, we can identify previously underacknowledged types of responses. We discuss the theoretical and practical implications for studying and using sustainability metrics as governance tools for responsible behaviour.
Like Oil and Water: The Politics of (Not) Assessing Glyphosate Concentrations in Aquatic Ecosystems
Authors: HENDLIN Yogi Hale , ARCURI Alessandra , LEPENIES Robert , HÜESKER Frank
Published: September 2020

Since the International Agency on Cancer Research’s monograph found glyphosate to be a likely carcinogen, the regulatory focus on the chemical has centred on this determinative criterion for regulatory action. Yet, other pertinent factors, such as the effects of glyphosate on fresh and ground water and ensuing effects on biodiversity, have received less attention as legitimate rationales for regulating the chemical. This underrepresentation prevents a wider policy discussion on the environmental and human health effects of the chemical and fails to disrupt assumptions of path-dependently continuing on agriculture’s chemical treadmill. To avoid ad hoc post hoc chemical regulation, we assess four areas of chemical regulatory oversight in Europe with regard to glyphosate affecting water: (1) the undue emphasis on in laboratorio versus in situ testing; (2) assessing single chemicals (isolated glyphosate) versus admixtures (glyphosate plus surfactants and adjuvants) that are used in practice; (3) the tendency to downplay harms to non-human life; and (4) the lack of policy coherence in the existing regulatory framework. Focusing on European Union regulation of pesticide and water policy affecting aquatic environments, we conclude that issues of measurement and priority have become highly politicised in both science and policy, requiring preventative, precautionary frameworks utilising plural forms of measurement.
Survey to determine the relative importance of clinical factors used to make empiric antibiotic decisions
Authors: Kim Casey , Szymczak Julia E. , Schnellinger Erin M. , Herman David J. , Kennedy Leigh A. , Talati Naasha J. , Hamilton Keith W.
Published: September 2020

A cross-sectional survey study of inpatient prescribers in a university health system was performed to assess the importance they place on different clinical risk factors when making empiric antibiotic decisions. Our findings show that these clinical risk factors were weighted differently based on the clinical scenario and the type of prescriber.
Intravital damage to the body ofDickinsonia(Metazoa of the late Ediacaran)
Authors: Ivantsov Andrey , Zakrevskaya Maria , Nagovitsyn Aleksey , Krasnova Anna , Bobrovskiy Ilya , Luzhnaya (Serezhnikova) Ekaterina
Published: September 2020

Several specimens ofDickinsoniacf.D.menneri, originating from a single burial event at the Lyamtsa locality of the late Ediacaran (Vendian) in the southeastern White Sea area, Russia, represent deviations from normal morphology: a reduction in the total length of the body; the loss of portions of the body; various deformations of the transverse elements, called isomers; and splitting of the longitudinal axis with the formation of two posterior ends. It is assumed that these deformations were formed as a result of non-lethal damage, which occurred long before the burial event, and the response ofDickinsoniato them. The progress of the regeneration process at the damaged areas, and especially its deviations, indicates that the growth zone was located at the posterior end of theDickinsoniabody. The cause of non-lethal damage toDickinsoniacould not be established, but the local distribution of deformed specimens preserved in the same burial event alongside cyanobacterial colonies, and the presence of weak deformations, expressed only in shortening of the length of some isomers, lead to the conclusion that damage resulted from short episodes of physicochemical impact, rather than occasional attacks by a hypothetical macrophage.
Single-seed cascades on clustered networks
Authors: McSweeney John K.
Published: September 2020

We consider a dynamic network cascade process developed by Duncan Watts applied to a class of random networks, developed independently by Newman and Miller, which allows a specified amount of clustering (short loops). We adapt existing methods for locally tree-like networks to formulate an appropriate two-type branching process to describe the spread of a cascade started with a single active node and obtain a fixed-point equation to implicitly express the extinction probability of such a cascade. In so doing, we also recover a formula that has appeared in various forms in works by Hackett et al. and Miller which provides a threshold condition for certain extinction of the cascade. We find that clustering impedes cascade propagation for networks of low average degree by reducing the connectivity of the network, but for networks with high average degree, the presence of small cycles makes cascades more likely.
Stochastic differential equations driven by fractional Brownian motion with locally Lipschitz drift and their implicit Euler approximation
Authors: Zhang Shao-Qin , Yuan Chenggui
Published: September 2020

In this paper, we study a class of one-dimensional stochastic differential equations driven by fractional Brownian motion with Hurst parameter $ H \gt \frac{1}{2}$. The drift term of the equation is locally Lipschitz and unbounded in the neighbourhood of the origin. We show the existence, uniqueness and positivity of the solutions. The estimates of moments, including the negative power moments, are given. We also develop the implicit Euler scheme, proved that the scheme is positivity preserving and strong convergent, and obtain rate of convergence. Furthermore, by using Lamperti transformation, we show that our results can be applied to stochastic interest rate models such as mean-reverting stochastic volatility model and strongly nonlinear Aït-Sahalia type model.