bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of videoconference-delivered psychotherapy for children, adolescents, and their parents: A meta-analysis of randomized controlled trials
Authors: von Wirth Elena , Willems Sarah , Döpfner Manfred , Kohl Lea Teresa
Published: September 2023

Introduction

Over the last years, videoconference-delivered psychotherapy (VCP) has found its way into clinical practice. This meta-analysis is the first to evaluate the effectiveness of VCP for children and adolescents with a mental disorder and their parents.

Methods

A systematic literature search was performed to identify randomized controlled trials (RCTs) that compared the effectiveness of VCP for youths with a mental disorder to a control condition. Twelve studies were included. Two reviewers independently extracted data and rated study quality.

Results

Effect size estimates for measures of children's symptoms of mental disorders were large for comparison between VCP and waitlist (posttreatment: Hedges's g = −1.26, k = 5) and negligible for comparisons between VCP and in-person treatment (posttreatment: g = 0.00, k = 6; follow-up: g = −0.05, k = 3). Similarly, effect size estimates for measures of children's functional impairments were large for comparison between VCP and waitlist (posttreatment: g = −1.10, k = 3) and negligible for comparisons between VCP and in-person treatment (posttreatment: g = −0.23, k = 3; follow-up: g = 0.04, k = 2). VCP more effectively reduced symptoms in children with an internalizing disorder ( g = −0.88, k = 5) compared to externalizing disorders ( g = 0.25, k = 2) or tic disorders ( g = −0.08, k = 3).

Discussion

The results provide preliminary evidence that VCP is an effective treatment for youths with a mental disorder and their parents. VCP was equally effective as in-person treatment in reducing children's symptoms and functional impairments. Limitations include the limited number of RCTs and incomplete reporting of methodological features.
Cultivating Latinx Undergraduates' Belonging and Persistence Through Relationally-Based, Culturally-Centered, and Interpersonally-Specific Mentorship
Authors: Delgado-Guerrero Marla , Gloria Alberta M.
Published: September 2023

Exploring the mentoring relationship of 19 Latinx undergraduates, this qualitative study highlighted the importance of mentoring and its influence on belonging, persistence, and retention. Findings confirmed the psychosociocultural framework as integrated through the Undergraduate Mentoring Model. Building on the tenet that “mentoring matters,” the current study was among the first to assess mentoring by mentor type (i.e., peer, staff, and faculty). Using a multistep content analysis, five metathemes emerged: 1) I have a someone who gets it … gets me, 2) imagining possibilities, 3) this is how you work the system, 4) I have someone I can relate with and look up to, and 5) I have someone who believes in me, encourages me, and motivates me to not give up. The findings underscored the importance of multiple mentors throughout Latinx students’ educational journeys and revealed that effective mentoring was developmental, relationally-based, culturally-centered, and interpersonally--specific.
Cream Skimming in an Early College High School: A First-Year Principal’s Dilemma in a High-Performing Campus
Authors: Duncheon Julia , DeMatthews David E. , Smith Taylor
Published: September 2023

Schools of choice need to provide equitable access and opportunities to all students, including students with disabilities and emergent bilinguals. In the context of Early College High Schools, principals and school districts should be partners in ensuring admissions processes are non-discriminatory. In this fictional case, a new principal in a high-performing early college high school becomes concerned that the school has been denying or not actively recruiting students with disabilities and emergent bilingual students. However, when she raises her concern with her supervisors and predecessor, she gets no support. The teaching notes of this case review the literature on ethical leadership, school administration dilemmas, and bounded ethicality.
A comparative study of an online mindfulness coursework: Implications for health and functioning and quality of life
Authors: Peterson Steve
Published: September 2023

This quantitative comparative study was conducted to examine if, and to what extent, differences in health and functioning and quality of life exist for community college students who complete an academic mindfulness course. Surveyed student responses were captured by the Quality of Life Index (QLI) ( Ferrans and Powers, 1985 ), dependent variables measured, and a non-directional two-tailed independent (unpaired) samples t test conducted. A univariate post-test only comparison group design was conducted to measure results of the mindfulness coursework intervention at the conclusion of the courses. A non-probability convenience sampling of 154 participants was collected, with both descriptive and inferential statics calculated. Data results indicated a statistically significant difference in health and functioning between the comparison and the intervention groups as well as quality of life between the comparison and the intervention groups. Effect size (Cohen’s d) at a 95% confidence interval for those students who completed a mindfulness course was large for the overall QLI score as well as the health and functioning subscale. This study demonstrated positive results and statistical significance suggesting the utility of mindfulness coursework. Recommendations from this study include integrating mindfulness coursework in a classroom setting and offering mindfulness training as a stand-alone academic course.
The relationship between health-related knowledge and attitudes and health risk behaviours among Portuguese university students
Authors: F. Alves Regina
Published: September 2023

Scientific evidence reveals a high prevalence of health risk behaviour among university students. This calls for the creation of educational programmes that promote more knowledge about health. However, knowledge alone is not enough to change behaviours; other factors should be considered, including attitudes towards health. The objective of this cross-sectional study was to analyse the relationship between knowledge, attitudes and health risk behaviours among university students. For this, a previously validated self-report questionnaire was applied to a stratified sample of 840 students, by year of study (first- and third-year students) and their scientific area. In addition to sociodemographic issues, the questionnaire contains a health-related knowledge scale, an attitudes towards health scale, and questions about health risk behaviours. Students displayed poor knowledge about health, correctly answering 17.77 (SD = 4.59) questions out of a total of 36, and moderate scores concerning attitudes towards health ( M = 2.61, SD = 0.48, range: 1–5). Students reported always engaging in, on average, 3.88 (SD = 1.45) of the seven behaviours subject to the analysis. Mediation analyses indicated that knowledge about health and attitudes towards health were statistically significant predictors of risky behaviours. Furthermore, it was indicated that attitudes towards health have a mediating effect between health knowledge and health risk behaviours. Findings from this study indicate that public health and education policies should promote healthy behaviours among university students, taking into account not only the level of knowledge but essentially the development of positive attitudes when facing behaviours which put health at risk.
“I am the pilot, but i need a committed crew”: Researching early childhood education and care leadership by using the actantial model of power
Authors: Heikkinen Kirsi-Marja , Ahtiainen Raisa , Kallioniemi Arto , Fonsén Elina
Published: September 2023

Leadership in Early Childhood Education and Care (ECEC) is changing globally. We investigated ECEC leadership and leaders’ interpretations of power and its realization between leaders and followers, a little researched topic in the field. Our theoretical framework consists of ECEC contextual knowledge and prior research attached with Michel Foucault’s and Mary Parker Follet’s perceptions of power as positive, relational and discursive microphenomenon. Our essay data ( N = 46) was written by ECEC center leaders before participating in educational leaders in-service training. The method of analysis was Greimas’ actantial analysis (1979), which enabled us to build two actantial models of leaders’ perspectives and relation to power. Findings indicate that power is a leader-centered, unstructured and hiding concept needing conscious reframing and integration of positional and non-positional leader roles in the community.
Antiangiogenic Activity of Mangostins Isolated from Thailand Stingless Bee Propolis
Authors: Ohta Toshiro , Ishizu-Nagashima Eriko , Mizuno Sayaka , Miyata Ryo , Vongsak Boonyadist , Kumazawa Shigenori
Published: September 2023

Background/Objective

Propolis, a resinous substance collected by honeybees from origin plants to protect their beehive, has been reported to have various biological activities and gained popularity as an alternative medicine in recent years. We have previously reported the plant origin, the chemical composition and some biological activities of native Thailand stingless bee propolis. In this study, we further elucidated its active components and their mode of action.

Methods/Results

Among nine prenylated xanthones isolated from this propolis, α-mangostin and γ-mangostin were shown to strongly inhibit tube formation of human umbilical vein endothelial cells (HUVECs), an indication of antiangiogenic activity in vitro. Further investigation of their effects at a molecular level revealed that both mangostins inactivated extracellular signal-regulated kinase 1/2 (ERK1/2) and activated p38 in tube-forming HUVECs in a concentration-dependent manner. Taken together, the two mangostins were shown to inhibit angiogenesis in vitro by inactivating angiogenic signal ERK1/2 and activating stress signal p38. Detailed comparison revealed that α-mangostin seemed to have a slightly stronger effect than γ-mangostin in these experiments. Combined with the fact that being the most abundant component among the nine prenylated xanthones tested, α-mangostin might be responsible for the antiangiogenic activity of this Thailand stingless bee propolis.

Conclusion

These results indicate that α-mangostin isolated from Thailand stingless bee propolis may be a good candidate for future applications in the prevention of angiogenesis-related diseases.
Recognizing the 2023 Fellows of the National Academy of School Nursing
Authors: Duff Carolyn L. , Delack Sandra , Johnson Kathleen , Davis-Alldritt Linda , Hlinomaz Joan
Published: September 2023

Membership as a Fellow in the National Academy of School Nursing (FNASN) is the NASN’s highest recognition award. At the 2023 NASN Conference, five new Fellows were inducted and now add FNASN to their credentials. This group of exemplary school nurse professionals contributes to school nursing practice in many ways that crisscross NASN’s Framework for 21st Century School Nursing Practice™. They each have chosen unique pathways to provide service. The 2023 NASN Fellows are: Eileen Gavin, New Jersey; Jenny Gormley, Massachusetts; Lynne Meadows, Georgia; Kathy Reiner, Colorado; and Sharonlee Trefry, Vermont. The following article outlines each Fellow’s unique path to attaining FNASN.
Just Playing the Role of Good Study Participants? Evaluative Conditioning, Demand Compliance, and Agreeableness
Authors: Ingendahl Moritz , Woitzel Johanna , Alves Hans
Published: September 2023

Evaluative Conditioning (EC) is the change in liking of stimuli due to their co-occurrence with other valenced stimuli. Recent research has shown stronger EC effects for more agreeable individuals. Because EC procedures are prone to demand characteristics, we hypothesized that more agreeable individuals might simply play the role of good study participants and therefore show stronger EC effects. We tested this in two preregistered experiments ( N = 700). In Experiment 1, self-reported Agreeableness and a behavioral measure of Demand Compliance moderated EC. However, Agreeableness and Demand Compliance were uncorrelated, and the moderations were independent. Experiment 2 used an instructional EC paradigm, showing only a moderation by Demand Compliance but not Agreeableness. Our studies imply that although EC effects are related to Demand Compliance, more agreeable participants are not more likely to comply with demand characteristics in EC experiments.
Perceptions and experiences of prenatal mental health: A qualitative study among pregnant women in Ghana
Authors: Agyekum Buruwaa Adomako
Published: September 2023

Prenatal mental health problems can have adverse effects on the health and wellbeing of the mother as well as her baby. However, the factors associated with its etiology, expression, and coping mechanisms in Ghana remain understudied. This qualitative study explored the perceptions and experiences of prenatal mental health problems among 21 pregnant women in Accra through semi-structured interviews. Interpretative Phenomenological Analysis led to three dominant themes; “conceptions of prenatal mental disorders” (sub-themes: awareness and constructions of prenatal mental health problems), “experiences of mental health problems” (sub-themes: symptoms of prenatal mental health problems and causal attributions of prenatal mental health problems) and “coping mechanisms of the pregnancy experience” (subthemes: faith, social support and work). The lack of knowledge of mental health disorders in this study and the expression of contextually relevant and culturally defined constructions and experiences of prenatal mental health problems, highlight the need for the development of culturally suitable interventions within the Ghanaian context.
Mental Health Screening Differences in Non-English Speaking Patients: Results From a Retrospective Cohort Study
Authors: Müller Frank , Abdelnour Alyssa M. , Rutaremara Diana N. , Arnetz Judith E. , Achtyes Eric D. , Alshaarawy Omayma , Holman Harland T.
Published: September 2023

Purpose:

To assess differences in mental health screening based on patient’s preferred language.

Methods:

For this retrospective cohort study, data for 85 725 unique patients from 10 primary care clinics in West Michigan were analyzed if patients received at least 1 mental health screening with the Patient Health Questionnaire 4 (PHQ-4) within a 12-month period (10/15/2021-10/14/2022). A general linear regression model was used to assess the adjusted odds ratios (aOR) of being screened.

Results:

Patients having a preferred language other than English (n = 2755) had an 87.0% chance of receiving the recommended mental health screening, compared to 76.7% of English-speaking patients ( P < .001). A multivariable model revealed decreased screening odds for Kinyarwanda (aOR 0.29, 95% CI 0.19-0.45) and Persian/Dari/Pashto (aOR 0.46, 95% CI 0.23-0.91) speaking patients and higher screening odds for Spanish (aOR 1.45, 95% CI 1.19-1.77), Bosnian (aOR 2.13, 95% CI 1.11-4.11), and Vietnamese (aOR 2.25 95% CI 1.64-3.08) speaking patients compared to English speaking patients.

Conclusions:

Results highlight the inequities between the language groups that are probably the result of the challenges to access multilingual depression and anxiety screening instruments. Furthermore, providers may be prone to bias about who they think “needs” a mental health screening. We suggest that measures are implemented to ensure consistency in mental health screening regardless of a patients’ preferred language.
Young Adolescent With Restricted Arm Motion During a Preparticipation Physical Exam
Authors: Potts Audrey A. , McLachlan Madison L. , Stoll Rebecca J. , Billings Thomas , Miller Nathaniel E.
Published: September 2023

A healthy 15-year-old right-hand dominant football player presented to the clinic for a preparticipation examination (PPE) with an exam notable for reduced right shoulder range of motion. The patient reported no complaints, including no pain. Upon questioning, he noted a remote non-sports related injury to that shoulder with unremarkable radiographs at that time. Subsequent X-ray imaging showed a bony abnormality thought to be consistent with an osteochondroma. However, advanced imaging identified it as a heterotrophic ossification center that required a complex, multidisciplinary surgical team to correct. This case of a high school football player’s routine PPE that resulted in surgery highlights not only whether sport participation is safe, but also the importance of direct, specific language that asks about the history of any injuries, rather than specifically sports related.
Cultural Value Adaptation in Advertising is Effective, But Not Dependable: A Meta-Analysis of 25 Years of Experimental Research
Authors: Hornikx Jos , Janssen Anne , O’Keefe Daniel J.
Published: September 2023

Advertisers sometimes use value appeals that are adapted to their specific cultural audience. After a meta-analysis in 2009 showing cultural value adaptation to be effective, new studies have been published and the advertising landscape has rapidly changed. The current meta-analysis involving about 120 comparisons of adapted versus unadapted value appeals on persuasion and ad liking presents three results. First, cultural value adaptation effects in advertising exist (persuasion: mean r = .049; ad liking: mean r = .055). Second, these adaptation effects have diminished over time (correlations between year of publication and persuasion effects: r = −.152; between year of publication and ad liking: r = −.185). Third, the adaptation effects do not allow for dependable advice for practitioners. We discuss these results in the context of globalization and the standardization-adaptation debate.
Fezolinetant: A New Nonhormonal Treatment for Vasomotor Symptoms
Authors: Onge Erin St. , Phillips Bradley , Miller Lisa
Published: September 2023

Objective: To review the safety, efficacy, and tolerability of fezolinetant for the treatment of vasomotor symptoms associated with menopause. Data Sources: A literature search was conducted through PubMed using the following search terms: fezolinetant, ES259564, SKYLIGHT, vasomotor symptoms, and menopause. Study Selection and Data Extraction: Selected articles included those which described clinical studies of the pharmacology, pharmacokinetics, efficacy, safety, or tolerability of fezolinetant. Data Synthesis: Fezolinetant works by inhibiting neurokinin B from binding to its receptor in the hypothalamus, thereby decreasing the occurrence of vasomotor symptoms. Clinical trials have demonstrated fezolinetant is superior to placebo in decreasing the frequency and severity of vasomotor symptoms. Common adverse effects associated with the use of fezolinetant include headache and gastrointestinal disturbances, as well as elevations in liver transaminase levels. Conclusions: Clinical practice guidelines for the treatment of vasomotor symptoms associated with menopause recommend hormone therapy as the most effective treatment option. Risks associated with hormone use may limit the use of this option in some patients. Neurokinin B inhibitors, like fezolinetant, target the physiologic cause of vasomotor symptoms. With the approval of fezolinetant, as well as elinzanetant which is currently in phase 3 clinical trials, providers and patients have additional nonhormonal treatment options for vasomotor symptoms associated with menopause.
Efficacy and safety of modular versus monoblock stems in revision total hip arthroplasty: a systematic review and meta-analysis
Authors: Wang Daofeng , Li Hua , Zhang Wupeng , Li Huanyu , Xu Cheng , Liu Wanheng , Li Jiantao
Published: September 2023

Background

Both modular and monoblock tapered fluted titanium (TFT) stems are increasingly being used for revision total hip arthroplasty (rTHA). However, the differences between the two designs in clinical outcomes and complications are not yet clear. Here, we intend to compare the efficacy and safety of modular versus monoblock TFT stems in rTHA.

Methods

PubMed, Embase, Web of Science, and Cochrane Library databases were searched to include studies comparing modular and monoblock implants in rTHA. Data on the survivorship of stems, postoperative hip function, and complications were extracted following inclusion criteria. Inverse variance and Mantel–Haenszel methods in Review Manager (version 5.3 from Cochrane Collaboration) were used to evaluate differences between the two groups.

Results

Ten studies with a total of 2188 hips (1430 modular and 758 monoblock stems) were finally included. The main reason for the revision was aseptic loosening. Paprosky type III was the most common type in both groups. Both stems showed similar re-revision rates (modular vs monoblock: 10.3% vs 9.5%, P = 0.80) and Harris Hip Scores (WMD = 0.43, P = 0.46) for hip function. The intraoperative fracture rate was 11.6% and 5.0% (P = 0.0004) for modular and monoblock stems, respectively. The rate of subsidence > 10 mm was significantly higher in the monoblock group (4.5% vs 1.0%, P = 0.003). The application of extended trochanteric osteotomy was more popular in monoblock stems (22.7% vs 17.5%, P = 0.003). The incidence of postoperative complications such as periprosthetic femoral fracture and dislocation was similar between both stems.

Conclusions

No significant difference was found between modular and monoblock tapered stems as regards postoperative hip function, re-revision rates, and complications. Severe subsidence was more frequent in monoblock stems while modular ones were at higher risk of intraoperative fracture.

Level of evidence: Level III, systematic review of randomized control and non-randomized studies.

Trial Registration: We registered our study in the international prospective register of systematic reviews (PROSPERO) (CRD42020213642).
National spine surgery registries’ characteristics and aims: globally accepted standards have yet to be met. Results of a scoping review and a complementary survey
Authors: Pascucci Simona , Langella Francesco , Franzò Michela , Tesse Marco Giovanni , Ciminello Enrico , Biondi Alessia , Carrani Eugenio , Sampaolo Letizia , Zanoli Gustavo , Berjano Pedro , Torre Marina
Published: September 2023

Background

Surgery involving implantable devices is widely used to solve several health issues. National registries are essential tools for implantable device surveillance and vigilance. In 2017, the European Union encouraged Member States to establish “registries and databanks for specific types of devices” to evaluate device safety and performance and ensure their traceability. Spine-implantable devices significantly impact patient safety and public health; spine registries might help improve surgical outcomes. This study aimed to map existing national spine surgery registries and highlight their features and organisational standards to provide an essential reference for establishing other national registries.

Methods

A scoping search was performed using the Embase, PubMed/Medline, Scopus, and Web of Science databases for the terms “registry”, “register”, “implantable”, and all terms and synonyms related to spinal diseases and national registries in publications from January 2000 to December 2020. This search was later updated and finalised through a web search and an ad hoc survey to collect further detailed information.

Results

Sixty-two peer-reviewed articles were included, which were related to seven national spine registries, six of which were currently active. Three additional active national registries were found through the web search. The nine selected national registries were set up between 1998 and 2021. They collect data on the procedure and use patient-reported outcome measures (PROMs) for the follow-up.

Conclusion

Our study identified nine currently active national spine surgery registries. However, globally accepted standards for developing a national registry of spine surgery are yet to be established. Therefore, an international effort to increase result comparability across registries is highly advisable. We hope the recent initiative from the Orthopaedic Data Evaluation Panel (ODEP) to establish an international collaboration will meet these needs.
Potential for high toxicity of polystyrene nanoplastics to the European Daphnia longispina
Authors: de Souza Machado Anderson Abel , Ghadernezhad Nesar , Wolinska Justyna
Published: September 2023

Background

Current regulatory discussions about microplastics are often questioned based on a lack of data indicating high ecotoxic hazards of these particles within standard and recognized definitions. Moreover, there is scientific debate on what metrics to report the micro-nanoplastics toxicity (i.e. mass or particle counts-based exposure). We present here the high potential sensitivity of three genotypically different clones of the European Daphnia longispina species complex exposed to non-functionalized polystyrene nanobeads of 50 nm and 100 nm in diameter according to adapted OECD 202 test protocol.

Results

EC50s 48 h varied from 0.2 to 8.9 mg L−1 (mean 2.49 mg L−1) for 50 nm beads, and from 32.7 to 90.3 mg L−1 (mean 59.39 mg L−1) for the 100 nm. EC10s 48 h varied from 0.0007 to 7.5 mg L−1 (mean 0.28 mg L−1) for 50 nm beads, and from 25.5 to 69.1 mg L−1 (mean 47.51 mg L−1) for the 100 nm. Inter-clonal variability was about tenfold. Therefore, several 1000 s-fold variations in mass-based ecotoxicity for these polystyrene beads was observed if particle size and Daphnia genotype are considered jointly.

Conclusions

Such ecotoxicity potential is comparable to highly toxic chemicals in global and EU-based regulatory classification and labelling. Ecotoxicity based on particle counts suggested convergence of EC50s, with effects generally observed around 1011 to1015 particles L−1. The present results highlight the potential high hazard of these particles and the relevance of particle size and exposure metrics on hazard conclusion.

Graphical Abstract
Comparative transcriptomic analysis of wheat cultivars differing in their resistance to Fusarium head blight infection during grain-filling stages reveals unique defense mechanisms at play
Authors: Chen Can , Guo Qi , He Qifang , Tian Zhuangbo , Hao Weihao , Shan Xinyu , Lu Jie , Barkla Bronwyn J. , Ma Chuanxi , Si Hongqi
Published: September 2023

Fusarium head blight (FHB) is a devastating fungal disease that poses a significant threat to wheat production, causing substantial yield losses. Understanding the molecular mechanisms of wheat resistance to FHB is crucial for developing effective disease management strategies. This study aimed to investigate the mechanisms of FHB resistance and the patterns of toxin accumulation in three wheat cultivars, Annong8455, Annong1589, and Sumai3, with different levels of resistance, ranging from low to high respectively, under natural field conditions. Samples were taken at three different grain-filling stages (5, 10, and 15 DPA) for gene expression analysis and phenotypic observation. Results found that toxin concentration was inversely correlated with varietal resistance but not correlated with disease phenotypes, indicating that toxin analysis is a more accurate measure of disease status in wheat ears and grains. Transcriptomic data showed that Sumai3 exhibited a stronger immune response during all stages of grain filling by upregulating genes involved in the active destruction of pathogens and removal of toxins. In contrast, Annong1589 showed a passive prevention of the spread of toxins into cells by the upregulation of genes involved in tyramine biosynthesis at the early stage (5 DPA), which may be involved in cell wall strengthening. Our study demonstrates the complexity of FHB resistance in wheat, with cultivars exhibiting unique and overlapping defense mechanisms, and highlights the importance of considering the temporal and spatial dynamics of gene expression in breeding programs for developing more resistant wheat cultivars.
Clinical characteristics and prognostic nomograms of 12555 non-severe COVID-19 cases with Omicron infection in Shanghai
Authors: Yin Chun , Hu Bo , Li Kunyan , Liu Xian , Wang Shuili , He Rulin , Ding Haibing , Jin Mingpeng , Chen Cheng
Published: September 2023

Background

Omicron variant of the severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has rapidly become a global threat to public health. Numerous asymptomatic and mild cases had been admitted in shelter hospitals to quickly win the fight against Omicron pandemic in Shanghai. However, little is known about influencing factors for deterioration and length of stay (LOS) in hospitals among these non-severe cases.

Methods

This study included 12,555 non-severe cases with COVID-19 in largest shelter hospital of Shanghai, aiming to explore prognostic factors and build effective models for prediction of LOS.

Results

Data showed that 75.0% of participants were initially asymptomatic. In addition, 94.6% were discharged within 10 days, only 0.3% with deterioration in hospitals. The multivariate analysis indicated that less comorbidities (OR = 1.792, P = 0.012) and booster vaccination (OR = 0.255, P = 0.015) was associated with the decreased risk of deterioration. Moreover, age (HR = 0.991, P < 0.001), number of symptoms (HR = 0.969, P = 0.005), time from diagnosis to admission (HR = 1.013, P = 0.001) and Cycle threshold (CT) values of N gene (HR = 1.081, P < 0.001) were significant factors associated with LOS. Based on these factors, a concise nomogram model for predicting patients discharged within 3 days or more than 10 days was built in the development cohort. In validation cohort, 0.75 and 0.73 of Areas under the curve (AUC) in nomograms, similar with AUC in models of simple machine learning, showed good performance in estimating LOS.

Conclusion

Collectively, this study not only provides important evidence to deeply understand clinical characteristics and risk factors of short-term prognosis in Shanghai Omicron outbreaks, but also offers a concise and effective nomogram model to predict LOS. Our findings will play critical roles in screening high-risk groups, providing advice on duration of quarantine and helping decision-makers with better preparation in outbreak of COVID-19.
Prevalence of allergen sensitization among children with allergic rhinitis in Changzhou, China: a retrospective observational study
Authors: Hu Zhibang , Xue Jianrong , Pan Min , Bao Yongzheng , Zou Wenlan , Wang Chunhui , Ma Jing
Published: September 2023

Objective

To determine the prevalence of sensitivity to common inhaled and food allergens among children with allergic rhinitis (AR) in Changzhou in eastern China and provide a basis for epidemiological research of pediatric allergic rhinitis and allergen avoidance in this region.

Methods

This was a retrospective observational study, a total of 1248 children with AR were enrolled at the Third People’s Hospital of Changzhou between January 2018 and December 2019. The serum-specific immunoglobulin E (sIgE) to 19 kinds of inhaled and food allergens and serum total IgE were detected with the AllergyScreen test (Mediwiss Analytic GmbH, Moers, Germany). All participants had a positive reaction to at least one allergen in the test (the sIgE concentration ≥ 0.35 IU/ml).

Results

Among the patients, 818 (65.54%) were male and 430 (34.46%) were female, with 81 (6.50%) aged 1–3 year, 501 (40.14%) aged 4–7 year, and 666 (53.36%) aged 8–14 year. The positivity rate of inhaled allergens was 80.05% (n = 999), while the positivity rate of food allergens was 66.19% (n = 826). 828 patients (66.35%) were sensitized to multiple allergens. The most common inhaled allergens were Dermatophagoides pteronyssinus (65.38%), mold mix (25.56%), house dust (20.67%), and dog hair dander (13.94%), and the most common food allergens were cow’s milk (30.31%), cashew nut (27.9%), egg (22.68%), and beef (12.98%). With an increase in age, the inhaled allergen positivity rate showed a significant increase (P < 0.01), while the food allergen positivity rate decreased significantly (P < 0.01). There were significant age differences in total IgE levels (P < 0.01) and the total IgE level was highest in the group aged 8–14 year.

Conclusions

Dermatophagoides pteronyssinus was the most common sensitizing allergen in pediatric patients with AR in Changzhou. Several other inhaled and food allergens were also common. We observed that multiple allergenic factors play an important role in the occurrence and development of AR.
Sleep, light exposure at night, and psychological wellbeing during pregnancy
Authors: Ng Choon Ming , Kaur Satvinder , Kok Ee Yin , Chew Wan Ling , Takahashi Masaki , Shibata Shigenobu
Published: September 2023

Background

Psychological wellbeing during pregnancy is imperative for optimal maternal outcomes. The present study aimed to determine the association between sleep quality, light exposure at night, and psychological wellbeing in the 2nd and 3rd trimesters of pregnancy.

Methods

This prospective study was conducted in 9 randomly selected government maternity clinics in Kuala Lumpur, Malaysia. Healthy women aged 20–48 years old with single pregnancy were recruited using convenience sampling (n = 169). Sleep quality, light exposure at night, and psychological wellbeing were self-reported using the Pittsburgh Sleep Quality Index (PSQI), Harvard Light Exposure Assessment (H-LEA), and Depression, Anxiety, and Stress Scale (DASS-21) in the 2nd trimester and followed-up at the 3rd trimester.

Results

During the 2nd and 3rd trimesters of pregnancy, mild to severe symptoms of stress (10.7 and 11.3%), anxiety (42 and 44.3%), and depression (9.6 and 16.6%) were observed among the participants. Adjusted multiple linear regression revealed that poor sleep quality and higher light exposure at night were attributed to greater stress and depression symptoms in the 3rd trimester. Higher lux level exposed from 10 pm to < 1 am was associated with increased stress (β = 0.212, p = 0.037) and depression (β = 0.228, p = 0.024). Only poor sleep quality was observed to adversely affect anxiety (β = 0.243, p = 0.002) and depression levels (β = 0.259, p = 0.001) in the 2nd trimester.

Conclusions

Present study provided preliminary findings on the association between sleep quality, light at night, and psychological wellbeing of pregnant women. As a recommendation, future research could investigate whether public health interventions aimed at decreasing artificial light at night can benefit sleep quality and the psychological health of pregnant women.
Machine learning techniques for the identification of risk factors associated with food insecurity among adults in Arab countries during the COVID-19 pandemic
Authors: Qasrawi Radwan , Hoteit Maha , Tayyem Reema , Bookari Khlood , Al Sabbah Haleama , Kamel Iman , Dashti Somaia , Allehdan Sabika , Bawadi Hiba , Waly Mostafa , Ibrahim Mohammed O. ,   The Regional CORONA COOKING Survey Group, De Backer Charlotte , Teunissen Lauranna , Van Royen Kathleen , Cuykx Isabelle , Decorte Paulien , Ouvrein Gaëlle , Poels Karolien , Vandebosch Heidi , Maldoy Katrien , Pabian Sara , Matthys Christophe , Smits Tim , Vrinten Jules , DeSmet Ann , Teughels Nelleke , Geuens Maggie , Vermeir Iris , Proesmans Viktor , Hudders Liselot , Al-Mannai Mariam , Alalwan Tariq , Naim Elissa , Mansour Rania , Yazbeck Nour , Agha Hazem , Seir Rania Abu , Arrish Jamila , Fallata Ghadir , Alhumaidan Omar , Alakeel Shihana , AlBuayjan Norah , Alkhunein Sarah , Binobaydan Budur , Alshaya Aeshah , Aldhaheri Ayesha , Polo Stephanny Vicuna , Al-Halawa Diala Abu
Published: September 2023

Background

A direct consequence of global warming, and strongly correlated with poor physical and mental health, food insecurity is a rising global concern associated with low dietary intake. The Coronavirus pandemic has further aggravated food insecurity among vulnerable communities, and thus has sparked the global conversation of equal food access, food distribution, and improvement of food support programs. This research was designed to identify the key features associated with food insecurity during the COVID-19 pandemic using Machine learning techniques. Seven machine learning algorithms were used in the model, which used a dataset of 32 features. The model was designed to predict food insecurity across ten Arab countries in the Gulf and Mediterranean regions. A total of 13,443 participants were extracted from the international Corona Cooking Survey conducted by 38 different countries during the COVID -19 pandemic.

Results

The findings indicate that Jordanian, Palestinian, Lebanese, and Saudi Arabian respondents reported the highest rates of food insecurity in the region (15.4%, 13.7%, 13.7% and 11.3% respectively). On the other hand, Oman and Bahrain reported the lowest rates (5.4% and 5.5% respectively). Our model obtained accuracy levels of 70%-82% in all algorithms. Gradient Boosting and Random Forest techniques had the highest performance levels in predicting food insecurity (82% and 80% respectively). Place of residence, age, financial instability, difficulties in accessing food, and depression were found to be the most relevant features associated with food insecurity.

Conclusions

The ML algorithms seem to be an effective method in early detection and prediction of food insecurity and can profoundly aid policymaking. The integration of ML approaches in public health strategies could potentially improve the development of targeted and effective interventions to combat food insecurity in these regions and globally.
Dynamicity, emerging patterns, and spatiotemporal trends of scientific production on the use of activated carbon in oral health: a scientometric study
Authors: Mayta-Tovalino Frank , Espinoza-Carhuancho Fran , Alvitez-Temoche Daniel , Mauricio-Vilchez Cesar , Munive-Degregori Arnaldo , Barja-Ore John , Pacheco-Mendoza Josmel
Published: September 2023

Background

The use of activated carbon (AC) in oral hygiene products has gained significant interest; however, its potential benefits for oral health remain uncertain. This study aimed to conduct a scientometric analysis to examine the dynamicity, emerging patterns, and trends over time in scientific production concerning the use of AC in oral health.

Methods

The Web of Science database was searched for articles published between 2005 and 2022. Various bibliometric indicators, including the H-index, annual growth, Lotka’s law, Bradford’s law, and Sankey diagram, were used for data analysis. Overlay maps, timezone visualization, and three field plots were used to evaluate visualization patterns, time–temporal relationships, and trends. Information retrieval process was performed on March 11, 2023.

Results

The analysis revealed that only six studies constituted the top references with the highest number of citations in recent years, with Brooks’ 2017 study demonstrating the most significant increase in citation. The dual-map overlay demonstrated a close citation relationship between cluster 4 (Molecular Biology Immunology) and the areas of Environmental, Toxicology, and Nutrition. The visualization graph of publication patterns indicated the journals that accumulated the highest number of citations during the study period.

Conclusion

This scientometric study provides valuable insights into the use of AC in oral health and its impact on the field of dentistry. It determines the most productive journals, authors, and countries with the greatest influence. AC effectively removes pollutants and is gaining interest for use in dental effluent treatment. Thus, it may be a viable option for professionals.
The efficacy of oxytocin gel in postmenopausal women with vaginal atrophy: an updated systematic review and meta-analysis
Authors: Farahat Ramadan Abdelmoez , Salamah Hazem Mohamed , Mahmoud Abdelrahman , Hamouda Esraa , Hashemy Mahmoud , Hamouda Heba , Samir Ali , Chenfouh Imane , Marey Ahmed , Awad Dina M. , Farag Elsayed , Abd-Elgawad Mohamed , Eldesouky Elsayed
Published: September 2023

Background

Genitourinary syndrome of menopause (GSM) is a common and disturbing issue in the postmenopausal period. Unlike vasomotor symptoms, it has a progressive trend. Our study aims to evaluate the efficacy and safety of oxytocin gel versus placebo gel in postmenopausal women with GSM.

Methods

A systematic review and meta-analysis synthesizing randomized controlled trials (RCTs) from Web of Science, SCOPUS, PubMed, and Cochrane Central Register of Controlled Trials databases on January 18, 2023. Keywords such as “oxytocin,“ “intravaginal,“ “vaginal,“ “atrophic,“ and “atrophy” were used. We used Review Manager (RevMan) version 5.4 in our analysis. We used the risk ratio (RR) for dichotomous outcomes and the mean difference (MD) for continuous outcomes; both were presented with the corresponding 95% confidence interval (CI) and were calculated with the Mantel-Haenszel or inverse variance statistical method. Cochrane’s Q test and the I2 statistic were used as measures of statistical inconsistency and heterogeneity. The Cochrane Risk of Bias Tool for RCTs was used for the quality assessment of the included studies.

Results

Seven studies with 631 patients were included. Regarding the maturation index, there was a statistically insignificant increase in the oxytocin arm (MD = 12.34, 95% CI (-12.52-37.19), P = 0.33). Clinically assessed vaginal atrophy showed a statistically significant reduction in the oxytocin group (RR = 0.32, 95% CI (0.23 − 0.10), P < 0.00001). For dyspareunia, vaginal pH, and histological evaluation of vaginal atrophy, there was a statistically insignificant difference between the two groups (RR = 1.02, 95% CI (0.82–1.27), P = 0.84), (MD = -0.74, 95% CI (-1.58-0.10), P = 0.08), and (MD = -0.38, 95% CI (-0.82-0.06), P = 0.09), respectively. There was no significant difference in the safety profile between the two groups as measured by endometrial thickness (MD = 0.00, 95% CI (-0.23-0.23), P = 0.99).

Conclusions

Although oxytocin has been proposed as a viable alternative to estrogen in the treatment of GSM, our findings show the opposite. Larger, high-quality RCTs are needed to confirm or refute our results.

Trial registration

PROSPERO registration number CRD42022334357.
Temporal trends in chronic complications of diabetes by sex in community-based people with type 2 diabetes: the Fremantle Diabetes Study
Authors: Davis Wendy A. , Davis Timothy M. E.
Published: September 2023

Background

Whether recent reductions in cardiovascular disease (CVD) events and mortality in type 2 diabetes apply equally to both sexes is largely unknown. The aim of this study was to characterize temporal changes in CVD events and related outcomes in community-based male and female Australian adults with type 2 diabetes or without known diabetes.

Methods

Participants from the longitudinal observational Fremantle Diabetes Study Phases I (FDS1; n = 1291 recruited 1993–1996) and II (FDS2; n = 1509 recruited 2008–2011) and four age-, sex- and postcode-matched individuals without diabetes (FDS1 n = 5159; FDS2 n = 6036) were followed for first myocardial infarction, stroke, heart failure hospitalization, lower extremity amputation, CVD death and all-cause mortality. Five-year incidence rates (IRs) for males versus females in FDS1 and FDS2 were calculated, and IR ratios (IRRs) derived.

Results

The FD1 and FDS2 participants were of mean age 64.0 and 65.4 years, respectively, and 48.7% and 51.8% were males. For type 2 diabetes, IRRs for all endpoints were 11–62% lower in FDS2 than FDS1 for both sexes. For participants without diabetes, IRRs were 8–56% lower in FDS2 versus FDS1 apart from stroke in females (non-significantly 41% higher). IRRs for males versus females across FDS phases were not significantly different for participants with type 2 diabetes or those without diabetes (P-values for male * FDS2 interaction ≥ 0.0.083 adjusted for age). For risk factors in participants with type 2 diabetes, greater improvements between FDS1 and FDS2 in smoking rates in males were offset by a greater reduction in systolic blood pressure in females.

Conclusions

The incidence of chronic complications in Australians with type 2 diabetes and without diabetes has fallen similarly in both sexes over recent decades, consistent with comparably improved overall CVD risk factor management.
A3DyDB: exploring structural aggregation propensities in the yeast proteome
Authors: Garcia-Pardo Javier , Badaczewska-Dawid Aleksandra E. , Pintado-Grima Carlos , Iglesias Valentín , Kuriata Aleksander , Kmiecik Sebastian , Ventura Salvador
Published: September 2023

Background

The budding yeast Saccharomyces cerevisiae (S. cerevisiae) is a well-established model system for studying protein aggregation due to the conservation of essential cellular structures and pathways found across eukaryotes. However, limited structural knowledge of its proteome has prevented a deeper understanding of yeast functionalities, interactions, and aggregation.

Results

In this study, we introduce the A3D yeast database (A3DyDB), which offers an extensive catalog of aggregation propensity predictions for the S. cerevisiae proteome. We used Aggrescan 3D (A3D) and the newly released protein models from AlphaFold2 (AF2) to compute the structure-based aggregation predictions for 6039 yeast proteins. The A3D algorithm exploits the information from 3D protein structures to calculate their intrinsic aggregation propensities. To facilitate simple and intuitive data analysis, A3DyDB provides a user-friendly interface for querying, browsing, and visualizing information on aggregation predictions from yeast protein structures. The A3DyDB also allows for the evaluation of the influence of natural or engineered mutations on protein stability and solubility. The A3DyDB is freely available at http://biocomp.chem.uw.edu.pl/A3D2/yeast.

Conclusion

The A3DyDB addresses a gap in yeast resources by facilitating the exploration of correlations between structural aggregation propensity and diverse protein properties at the proteome level. We anticipate that this comprehensive database will become a standard tool in the modeling of protein aggregation and its implications in budding yeast.