bluuebunny/crossref_metadata_2025 huggingface dataset:
Comprehending and Domesticating of Wild Growing Turkey Tail Mushroom (Trametes versicolor) from Ethiopia on augmented agro-industrial byproducts
Authors: Desisa Buzayehu , Muleta Diriba , Jida Mulisa , Dejene Tatek , Goshu Abayneh , Negi Tadesse , Martin Pablo
Published: November 2023

Despite being one of the most studied white-rot fungi, nothing has been done to discover and domesticate Ethiopia's high-yielding wild Trametes versicolor. Thus, this study was initiated to evaluate the growth performance of T. versicolor on growth media. Accordingly, ten substrates (S1–S10) were formulated by a combination of agroindustrial by-products that mainly constituted sugarcane wastes and animal manures. The effect of substrates on yields, biological efficiencies, and nutritional compositions was examined. The mushroom developed a white, cottony mass on the growth media. T. versicolor cultivated on the S5 combination of 80% sugarcane bagasse, 12% horse manure, and 8% poultry manure had the highest yield (158.33 g/500 g bag) and biological efficiency (31.5%), which had an optimum 31:1 C:N. It has shown good mycelial growth, short colonization, and short pinhead formation time compared to other substrates. Low biological efficiency and yields of 11.50% and 57.67% were obtained from S7, which was not supplemented with nitrogen sources. The content of crude protein, fiber, low fat, and carbohydrates were in the range of 7.46–14.65%, 12.89–18.38%, 0.42–0.53%, and 48.75–66.75%, respectively. The highest nutritional values were obtained from S5, except for carbohydrates from sugarcane bagasse mixed with cotton seed hull (S8). Thus, S5 was found to be a suitable growth medium for domesticating wild T. versicolor mushrooms, particularly in regions where poultry, horse manures, and sugarcane bagasse are abundantly available. Hence, S5 is an optimum substrate for T. versicolor cultivation to improve productivity and nutritional quality at lower costs.
Re-thinking Indoor Humidity Control Strategies: The potential of additive manufacturing with low-carbon, super hygroscopic materials.
Authors: Posani Magda , Voney Vera , Odaglia Pietro , Brumaud Coralie , Dillenburger Benjamin , Habert Guillaume
Published: November 2023

Indoor humidity plays a major role in our comfort and well-being. For this reason, mechanical systems are often used to regulate indoor humidity levels, a choice that can entail relevant embodied and operational carbon emissions. This study offers an alternative solution: using materials that naturally buffer moisture to passively regulate indoor humidity levels.
In this work, a geopolymer composite incorporating industrial waste is implemented via a binder jet 3D-printing technology. The combination of the super hygroscopic nature of the material and optimal geometry allows for an effective reduction of embodied emissions and unlocks an unprecedented potential for passive regulation of indoor humidity. Results show that the adoption of 3D-printed geopolymer-based tiles can improve the annual indoor hygrometric conditions by up to 90% in a library hosting 15 people: a passive performance that is inconceivable to obtain with conventional building materials and manufacturing methods. The 3D-printing technology allows for optimal usage of material and consequent lower embodied emissions. In the case study considered, the environmental impact of using 3D-printed tiles emerges to be lower than adopting a conventional dehumidification system to actively achieve equivalent indoor hygrometric comfort levels over a 15-year time span.
The outcomes of this study pave the way towards merging super hygroscopic low carbon materials with the advanced manufacturing technique of binder jetting in order to regulate indoor humidity levels and reduce indoor environments' dependency on mechanical systems.
Epigenetic Regulation of Host Membrane Protein-encoding Genes Facilitates African Swine Fever Virus Infection
Authors: Zhao Shuhong , Qi Xiaolong , Xiang Yue , Sun Limeng , Xing Lingyu , Zhang Jinfu , Zhang SaiXian , Zhao Qiulin , Guo Yilin , Zhang Lu Zhang Lu , Li Jingjin , Zhou Peng , Zheng Zhuqing , Dai Xueting , Jin Zhe , Jian Yaobang , Li Guosheng , Fu Yanan , Tan Yubei , Zhao Changzhi , Xie Shengsong , Cao Gang , Li Xinyun , Fang Lingzhao , Fu Liangliang , Peng Guiqing
Published: November 2023

African swine fever virus (ASFV) is a highly contagious pathogen specifically infecting porcine alveolar macrophages (PAMs), causing substantial economic losses in pig industry worldwide. However, host receptors and molecular mechanisms underlying the ASFV infection remain unknown, which hinders the relevant vaccine development and precision breeding. Here, we conducted a comprehensive epigenetic profiling of ASFV-exposed PAMs based on the generated 42 functional datasets at both bulk and single-cell resolution. The results showed that transcriptional activity of ARL4C in ASFV-exposed cells was downregulated, thus resulting in intracellular cholesterol accumulation to enhance viral defense. In contrast, ASFV infection induced enhancer-promoter interactions in the host genome to boost transcriptional activity of membrane protein-encoding genes, thereby promoting macrophage activation. Moreover, transcriptional activity of these genes was induced in actively infected macrophages (carrying viral DNA). The gene knockout experiment and the virion attachment assay identified CD244 as a potential host receptor of ASFV, which was associated with host susceptibility. Our findings provide novel insights into the molecular regulation of PAMs during ASFV infection and lay a foundation for vaccine development and precision breeding against ASFV infection.
Neuromodulatory effects of caffeine, vanillin and their combination via the assessment of hippocampal purinergic enzymes and expressions of cholinergic, eNOS, GABA receptor, amyloid protein and histomorphological status of AlCl3-induced Alzheimer’s disease in adult male Wistar rats
Authors: Afolabi Olakunle , Jaiyesimi Kikelomo Folake , Olasehinde Oluwaseun Ruth , Olaoye Oyindamola Adeniyi , Ekakitie Lisa Ilobekemen , Fafure Adedamola Adediran , Adetunji Adedeji Enitan , Oluwafemi Emmanuel Babatunde , Oloyede Omo Ibidun
Published: November 2023

The neurotoxic properties of aluminum (Al) have been associated with Alzheimer's disease (AD) development. Consequently, there has been an increasing interest in exploring how bioactive compounds from functional foods can mitigate the detrimental impact of this redox metal in AD. Hence, this study evaluated neuromodulatory effects of caffeine, vanillin and their combination on some hippocampal biochemical parameters in AlCl3-induced AD. Thirty-six (36) adult male Wistar rats (150–200 g) were randomly divided into 6 treatment groups of 6 rats each. Animals were exposed to AlCl3 (100 mg/kg body weight, bw) orally at a single dose to induce AD. Experimental AlCl3-induced animals were administered with 50 mg/kg bw caffeine, vanillin and their combination for 21 days with donepezil (10 mg/kg bw) as control. However, following the 21 days treatment with 50 mg/kg caffeine, vanillin and their combination, a noticeable significant (p < 0.05) decrease was observed in the hippocampal ENTPDase activity with a concomitant increase significantly (p < 0.05) in eNTDase activity, respectively. Also, a significant (p < 0.05) reduction was evident in the hippocampal relative mRNA gene levels of eNOS, AChE and β-amyloid protein with no significant difference in the expression of GABA receptor protein in some treatment groups compared to untreated AlCl3-induced control group. Similarly, hippocampal architecture revealed restoration of dentate gyrus with an increased granular cell counts after the 21 days of treatment. Thus, according to our findings, the ability of caffeine, vanillin and their combination to modulate hippocampal purinergic system and expressions of some vital proteins in AlCl3-induced AD could possibly be a potential therapy in the management of AD.
Outcomes of parenteral nutrition in patients with advanced cancer and malignant bowel obstruction
Authors: Velasquez David A. , Dhiman Ankit , Brottman Colette , Eng Oliver S. , Fenton Emily , Herlitz Jean , Lozano Edward , McDonald Edwin , Reynolds Valerie , Wall Elizabeth , Whitridge Jeffrey , Semrad Carol , Turaga Kiran , Micic Dejan
Published: November 2023

Background
Malignant bowel obstruction (MBO) affects 3–15% of all cancer patients. In patients with advanced cancer and inoperable MBO, the average survival varies between four to nine weeks. Parenteral nutrition (PN) may improve survival in specific patient populations with malignant bowel obstruction.
Aims
This retrospective, single-center cohort study aimed to review individual patient outcomes on PN in the setting of advanced cancer with a diagnosis of MBO and identify clinical and laboratory markers predictive of short- and long-term survival to further highlight patients that would benefit from PN in the setting of an inoperable MBO.
Results
In a retrospective analysis of 68 patients receiving PN for inoperable MBO, the median survival was 142 (IQR: 63.3-239.5) days. Patients experienced a median number of two hospital readmissions (range: 0–10) and spent a median of 29 days (range: 0-105) in the hospital after starting PN. Eighteen (26.5%) patients developed a catheter-related bloodstream infection (CRBSI). A diagnosis of appendiceal cancer was identified as a predictive marker of improved survival (HR: 0.53, 95% CI: 0.29–0.92, p = 0.023).
Conclusions
The use of PN in the context of end-of-life cancer care is a practice that necessitates improvement. Recognizing the outcomes and patient experiences of PN utilization is essential to physicians and patients.
A rare co-occurrence of invasive mucinous adenocarcinoma, unilateral renal agenesis, and bicornuate uterus: Is it a new triad?
Authors: Mbwambo Orgeness Jasper , Anthony Jonaviva , Mremi Alex , Ngowi Nicholas B. , Mvunta David H.
Published: November 2023

Background
Concomitant invasive mucinous adenocarcinoma, unilateral renal agenesis and bicornuate uterus is a rare combination. Unilateral renal agenesis has been associated with genital anomalies, such as unicornuate and bicornuate uterus. Furthermore, a wealth of studies has reported the association between unicornuate uterus and ovarian anomalies, such as the absence of an ovary or ectopic ovaries, but rarely has there been a combination of the three to the best of our knowledge. The present case report is the first case presentation with a combination of the three syndromes: ovarian mucinous tumor, unilateral renal agenesis, and bicornuate uterus.
Case Presentation:
We report the case of a 17-year-old who presented with abdominal distension. On examination, a CT scan revealed a large multicystic abdominal mass on the right side, with an absence of the right kidney while the left kidney was normal in size, appearance, and position. Intraoperatively, massive blood-stained ascitic fluid was evacuated. Additionally, a large whitish polycystic intra-abdominal mass with mucus-like materials and solid areas was attached to the midpoint of the colon and the right ovary, with visible metastasis to the omentum. The uterus was bicornuate. The mass and omentum were taken for histopathology and a diagnosis of invasive mucinous cystadenocarcinoma with metastasis to the colon and omentum was made after a pathological report.
Conclusions
The presence of these conditions in the same individual could potentially complicate medical management and fertility considerations. Thus, a need for a multidisciplinary medical team, including gynecologists, urologists, and oncologists, to address their unique needs and provide appropriate treatment and guidance. Further research and case studies are needed to better understand the possible association and implications of these rare co-occurring conditions.
Removal of fluoride ions from aqueous solutions on unmodified and iron-modified hydrogels
Authors: Rosendo-González Veronica , Gutiérrez-Segura Edith Erielia , Solache-Rios Marcos , Amaya-Chavez Araceli
Published: November 2023

Unmodified and iron-modified hydrogels were synthesized from polyvinyl alcohol and polyvinylpyrrolidone; these materials were used for the adsorption of fluoride ions from an aqueous solution. The structural and morphological characteristics of the unmodified (HG) and modified (HG-Fe) hydrogels were determined by means of hydration percentage, point of zero charge (PZC), infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and dispersive energy spectroscopy (EDS). The parameters considered in the adsorption processes were contact time, pH, fluoride concentration and dosage. The kinetic data were obtained at an initial pH of 6.7 and were best fitted to the Elovich model (R2 = 0.994); the adsorption capacity was higher for HG-Fe than HG. The data obtained at pH 5 were adjusted to the Lagergren equation indicating physical adsorption. The capacities of both materials (HG and HG-Fe) were similar, and the equilibrium time was shorter for HG than HG-Fe. The isotherms were best fitted to the Langmuir model, indicating homogeneous materials. The maximum adsorption capacities were similar for both adsorbents (HG-Fe and HG), and the thermodynamic parameters showed that the processes are exothermic.
Advancing the Boundary of Pre-trained Models for Drug Discovery:Interpretable Fine-Tuning Empowered by Molecular Physicochemical Properties
Authors: Pan Xiang , Lian Xiaoqing , Zhu Jie , Lv Tianxu , Hong Xiaoyan , Ding Longzhen , Li Lihua , Jiang Chunjuan , Ni Jianming
Published: November 2023

The field of drug discovery has seen the emergence of several pre-trained models that exhibit exceptional performance across a range of downstream tasks. However, these pre-trained models resulting with large models and black-box models, which often break down when predicting data for which limited supervised information is available and lack interpretability, still is a major barrier for transformation integration of drug discovery. This paper pushes the boundaries of pre-trained models in the realm of drug molecules by introducing a novel fine-tuning framework known as the Head Feature Parallel Adapter (HFPA), which is designed to be highly interpretable, high-performing, and minimal parameters. Specifically, Our fine-tuning approach partitions the pre-trained model's general chemical feature space into specific molecular physicochemical property feature spaces. Adapter modules with minimal parameters are introduced for each of these spaces, enabling focused exploration of atomic and chemical bond knowledge. The specialized feature spaces are then recombined into the original chemical feature space size, enhancing the model's interpretability through fine-grained feature acquisition. Furthermore, our work offers comprehensive interpretability analysis for hyperparameter selection, providing valuable insights to guide chemists in understanding specific physicochemical properties of molecules. We conducted an extensive series of experiments that demonstrated the superiority of our approach. It outperformed other fine-tuning methods in seven physiology and toxicity prediction tasks. Furthermore, to explore the generalization capability of HFPA on different types of tasks, we also tested it on three physical chemistry tasks, achieving state-of-the-art results.
Decoding peanut smut: A bibliometric analysis of two decades of research progress
Authors: Cazón Luis Ignacio , Paredes Juan Andrés , Miretti Esteban , Gonzalez Noelia , Suarez Lautaro , Conforto Cinthia , Rago Alejandro Mario
Published: November 2023

Since its first report in commercial peanut fields in 1995, the prevalence and yield impact caused by peanut smut disease have rapidly increased. Simultaneously, various research groups have studied this pathosystem using different approaches, contributing to the scientific understanding of the disease. Recognizing the importance of a comprehensive bibliographic review and organized information, this work aims to provide a thorough scientometric analysis of the evolution of peanut smut research from its inception to the present day. To achieve this goal, bibliographic data about the disease were compiled, and metrics were calculated. The analysis revealed that a smaller proportion of the scientific production was published in peer-reviewed journals, with epidemiology and breeding being the predominant topics. Collaborative efforts played a pivotal role in advancing the study of this pathosystem. The research also identified the researchers with the most significant presence in the publications, the institutions involved, and the impact of the papers produced, among other trends. Despite significant scientific and technological advances in peanut smut research, these advances are not adequately represented in peer-reviewed journals, presenting a challenge for researchers in this field. It is crucial to continue generating knowledge to contribute to the integrated management of this complex pathosystem, preventing further yield losses and the pathogen's spread to new production areas.
TiO2 - SnO2 nanocomposite for photocatalytic degradation of acid red 37 dye in aqueous solutions under UV-Light
Authors: Sadik Wagih Abdel Alim Sayed Ahmed , Eldemerdash Abdelghaffar Magraby , Nashed Adel William , Mostafa Amr Ahmed , Elsayed Elsayed Lamie
Published: November 2023

The use of UV irradiation in conjunction with oxidants or catalysts (TiO2) to treat industrial wastewater has piqued interest as a viable alternative to traditional approaches. The purpose of this research is to investigate the preparation and characterization of TiO2 – SnO2 nanocomposites with various ratios, as well as their application in the photocatalytic degradation of acid red 37 dye in aqueous solution under UV irradiation as a model pollutant. XRD, TEM, EDAX, FTIR, were used to characterise. The photocatalytic degradaion was studied with different advanced oxidation processes using UV/TiO2, UV/ SnO2, UV/TiO2 – SnO2 (97 : 3 ), UV/TiO2 – SnO2 (93 : 7 ), UV/TiO2 – SnO2 (90 : 10 ), UV/TiO2 – SnO2 (85 : 15 ), UV/TiO2 – SnO2 (80 : 20 ), UV/TiO2 – SnO2 (90 : 10 ) /H2O2, UV/TiO2 – SnO2 (90 : 10 ) /Na2S2O8 and UV/TiO2 – SnO2 (90 : 10 ) /NaIO4 using a batch photoreactor.
Trauma and Management
Authors: Occhionorelli Dott. Savino , Maruca Dott. Alberto Maria , Lacavalla Dott. Domenico , Bianchera Dott. Andrea , Andreotti Dott. Dario , Stano Dott. Rocco
Published: November 2023

Worldwide, more than nine people die every minute from accidents or abuse and 5.8 million people of all ages and economic classes die every year from accidental injuries. This retrospective study aims to describe the statistical trends regarding trauma management in our hospital “Arcispedale Sant’Anna, Azienda Ospedaliero Universitaria di Ferrara” between March 2010 and December 2019, identifying 575 trauma patients who were first admitted to the Emergency Department then transferred to the Emergency General Surgery Department. For each patient data about sex, age, cause of trauma, dynamic of trauma, triage color, pain scale, Trauma Team activation (TTA), Injury Severity Score (ISS) and body regions affected from the trauma were collected and for each of the latter categories were analyzed sex distribution, causes of trauma, and median age. The Cribari Matrix Method (CMM) was also applied in order to identify potential overtriage and undertriage. This study provided us important relations between trauma and both age and sex, also proving the coherence between ISS and triage color assignation, dynamic of trauma, and mortality. The CMM index proved the achievement for our Hospital, a first level facility equipped with a second level Emergency Department, of the benchmarks for overtriage rates but not for undertriage ones by the American College of Surgeons Committee on Trauma (ACS COT) recommendations.
Loss-of-function mutation in DDX53 associated with hereditary spastic paraplegia-like disorder
Authors: Yuan Xiangshu , Wang Ya , Li Xiyuan , Zhong Sheng , Zhou Danyi , Lin Xianlong , Wang Maofeng , Yang Yanling , Fang Hezhi
Published: November 2023

DEAD-box helicase 53 (DDX53) is a member of the DEAD-box protein family of RNA helicases. Unlike other family members that are responsible for RNA metabolism, the biological function of DDX53 and its impact on the human condition are unclear. Herein, We found 21 patients with loss-of-function variants at DDX53, of whom 19 patients exhibited neurological disorders. Notably, a local patient with a full-length DDX53 deletion mutation had hereditary spastic paraplegia-like (HSP-like) clinical manifestation with lower extremity spasticity, intellectual disability, walking disorder, visual impairment, and lateral ventricular white matter lesions. Bioinformatic analysis revealed that DDX53 was mainly expressed in the cerebellar cortex and may function as a tissue-specific RNA helicase. Transcriptome analysis showed that the expression of multiple brain-associated genes involved in synapse organization, neuron function, and neuromuscular junctions was affected by DDX53 depletion. Moreover, RNA immunoprecipitation sequencing (RIP-seq) analysis showed that DDX53 interacted with 176 genes, and 97 of these genes were associated with the execution of neurofunction, particularly in the regulation of cell projection organization and nervous system development. Collectively, although a more specified cell or animal model is required to fully understand the functional role of DDX53 in the human brain, we report for the first time that DDX53 is required for the maintenance of neuronal function and that loss-of-function mutations in DDX53 may cause HSP due to impaired RNA metabolism in the nervous system.
Optical properties of daily used water inside Kathmandu valley
Authors: Koirala Sudhan , Neupane Damodar , Mulmi Deependra Das , Dhobi Saddam Husain
Published: November 2023

This article comprehensively examines the characteristics of water samples sourced from diverse locations in the Kathmandu Valley, encompassing density, transmittance, absorption coefficient, mass attenuation coefficient, and molecular cross-section area, across varying temperatures. Density variations, within a temperature range of 8°C to 48°C, are reported, spanning from 1.000140 to 1.177248 g/cm³. Transmittance increases with wavelength and exhibits temperature-related variations due to differing impurities among sources. The relationship between transmittance and temperature lacks a distinct pattern, influenced by unique source impurities and temperature effects. Moreover, the molecular cross-section area (MCA) estimates particles to be approximately 10− 24cm2. Additionally, the mass attenuation coefficient consistently decreases with wavelength across all samples. These findings provide a comprehensive insight into the intricate interplay between water properties, impurities, temperature, and radiation interactions in various water sources.
Factors associated with patients’ experience of accessibility to general practice: results from a national survey in Norway
Authors: Jelin Elma , Bjertnaes Oyvind , Norman Rebecka Maria
Published: November 2023

Background:
In the landscape of healthcare quality assessment, understanding patient experiences is vital. Positive patient experience correlates with high-quality clinical outcomes and reduced healthcare utilization thus, improving access to general practice is one of the current priorities in numerous healthcare systems. This study aimed to explore patient, general practitioner (GP), and practice level predictors of patient-experienced accessibility, including a composite index containing accessibility items. The secondary aim was to gain a deeper understanding of patient-perceived accessibility through free-text comments.
Methods:
Data was collected from a national survey of patient experiences with general practice in Norway (2021-2022). We identified 7 accessibility-related items from the Norwegian patient experiences with GP questionnaire (PEQ-GP) and computed a composite index score of accessibility. Predictors consisted of patient’s self-reported characteristics, as well as background data about the GP and GP practice. The analysis included univariate analyses, and seven logistic regression models, following an evaluation of the need for multilevel modelling by estimating the intraclass correlation coefficient (ICC) and the design effect statistics for the seven dependent variables. In addition, we performed a multiple linear regression with the index score of accessibility. Finally, a qualitative analysis was conducted of free-text survey comments among patients that had a score of 0 (unfavorable) on all the seven accessibility items one of the main themes.
Results:
The total number of responses was 7,912 (42%). The main predictor associated with patient-perceived accessibility was whether patients normally see their own GP. This result was highly significant (p<0.001) and in positive association both with all seven accessibility items in logistic regression analyses with OR ranging from 3.208 -1.756, as well as in the multiple linear regression with the index score. In addition to patient/GP continuity; self-reported mental health, practice size, and GP specialization were the strongest predictors. Qualitative analyses confirmed patients' inability to see their own GP as a central theme.
Conclusions:
In summary, the findings underscore the critical role of patient/GP continuity to enhance accessibility. Strengthening patient access to healthcare services and fostering meaningful patient-provider relationships should be used to inform efforts of better organizing and improving future general practice.
Comparison of the demographics of residential rooftop and community solar adopters
Authors: O'Shaughnessy Eric , Barbose Galen , Kannan Sudha , Sumner Jenny
Published: November 2023

Rooftop and community solar are alternative product classes for residential solar in the United States. Community solar, where multiple households buy solar from shared systems, could make solar more accessible by reducing initial costs and removing adoption barriers for renters and multifamily building occupants. Here, we test whether existing community solar projects have expanded solar access in the United States. We find that community solar adopters are more likely to live in multifamily buildings than rooftop solar adopters, are more likely to rent, and to a lesser extent tend to earn less income. We do not find that community solar expands access in terms of race. These differences are driven, roughly evenly, by inherent differences between the two solar products and by policies that specifically target low-income community solar adoption. The results suggest that alternative solar products can effectively expand solar access and that policy could augment such benefits.
Completion of Maternal and Child Health Continuum of Care and Associated Factors Among Women in Gode District, Shebele Zone, Eastern Ethiopia ,2022
Authors: Ayehubizu Liyew Mekonen , Yohannes Semehal Haile , yadeta zemenu Shiferaw , Fetene Metsihet Tariku
Published: November 2023

Background
The Continuum of care for reproductive, maternal, newborn, and child health includes integrated service delivery for mothers and children from pre-pregnancy to delivery, the immediate postnatal period, and childhood. In Ethiopia, the magnitude of antenatal care, skilled delivery, postnatal care, and immunization for children have shown improvement. Despite this, there was limited research on the percentage of mothers who have completed maternal and child continuum care.
Objective
To assess the Completion of Maternal and Child Health Continuum of Care and Associated Factors among women in Gode District, Shebele Zone, Eastern Ethiopia ,2022.
Method
A community-based cross-sectional study design applied from November 1–15, 2022. A stratified sampling method was applied. A woman who gave birth in the last year preceding the data collection period will be included in the study. An interviewer-administered semi-structured questioner will be used for data collection. Data collected by using kobo collect and analyzed using STATA version 17. Both Bivariable and multivariable logistic regression analyses will be done. In multivariable analysis, variables having P-values less than 0.05 will be taken as factors associated with the completion of the maternal and child health continuum of care.
Result
The Completion of MCH continuum of care was 13.5% (10.7%-17.0%) in Gode district,2022. Accordingly, Husband occupation (Government employee) [AOR = 2.3, 95%CI:(1.2–4.7)] and perceived time to reach health facility (less than 30 minutes) [AOR = 2.96, 95%CI:(1.2–7.5)] were factors showing significant association with maternal and child health continuum of care among mothers in Gode district, Somali regional State;2023 at P-value ≤ 0.05.
Conclusion and recommendation: Only
13.5% of mothers in Gode district received all of the recommended maternal and child health services during their pregnancy, childbirth, and postpartum period. The study found that two factors were associated with a higher likelihood of receiving MCH continuum of care: husband occupation and perceived time to reach a health facility. Governments can play a key role in increasing the maternal and child health continuum of care by investing in health care infrastructure
Relationship between hypomagnesaemia and ICU mortality in patients with severe intracerebral hemorrhage
Authors: Jiang Xinzhao , Gao Faliang , Shi Zongjie , Liu Fang , zhao Wenyan , Sun Qihong
Published: November 2023

Objectives
This study aims to explore the relationship between hypomagnesemia and mortality in severe intracerebral hemorrhage (ICH) patients.
Methods
In this study, 2026 patients with ICH from the Electronic Intensive Care Unit Collaborative Study database were enrolled. Two groups were classified based on the serum magnesium levels of ICH patients: hypomagnesemia and non- hypomagnesemia groups. Primary outcome was ICU mortality. Secondary outcomes were ICU stay time and mechanical ventilation use. Multivariable logistic regression analyses were used to study the relationship between hypomagnesemia and ICU mortality. We also performed a cumulative survival rate analysis by Kaplan-Meier curves.
Results
We enrolled a total of 2026 severe ICH patients who were older than 16 years and were hospitalized in the ICU for more than 24 hours. Of these, 277 (13.7%) patients died in the ICU. We observed hypomagnesemia in 489 patients. Multivariable logistic regression analyses demonstrated that hypomagnesemia was related to a 38% increased risk of ICU mortality, a prolonged length of ICU stay of 45.11 hours, as well as a 67% increased risk of mechanical ventilation use in severe ICH patients.
Conclusion
Our study suggested that hypomagnesemia was related to a higher risk of ICU mortality, longer ICU stay time, and a higher risk of mechanical ventilation use in patients with severe ICH. However, further randomized, prospective and controlled studies are needed to confirm these findings.
Causal relationships between new 412 gut microbiota, 731 inflammatory cells,91 inflammatory proteins and circulating leukocytes and subarachnoid hemorrhage: a Multi-omics, Bidirectional Mendelian randomization study and Meta-analysis
Authors: Yan Congzhi , Li Yun
Published: November 2023

Background
A neurological emergency with potentially fatal outcomes is subarachnoid hemorrhage (SAH). Arachnoid and soft meninges are separated by a tiny gap called the subarachnoid space. The term "SAH" describes a clinical state brought on by bleeding into the subarachnoid space as a result of diseased or damaged blood vessels rupturing at the base or surface of the brain.
Methods
To obtain preliminary results, this study integrated the use of several omics with Mendelian randomization analysis and MR-IVW, MR Egger, MR weight median, and MR weight mode. Reverse Mendelian randomization analysis using subarachnoid hemorrhage as exposure. Lastly, to get a summary of the findings, conduct a meta-analysis on the preliminary data.
Results
GBPA-Pyridoxal 5 photosphate biosynthatis I (OR = 1.48,95% CI, 1.04–2.12) and GBPA-glucose biosynthesis I(OR = 0.68,95% CI, 0.52–0.90)is positively correlated with SAH. The urokinase type plasma activator levels showed a positive correlation with SAH (OR = 1.17,95% CI, 1.04–1.32).CD80 on CD62L + Plasmacytoid Dendritic Cell, CD80 on plasmacytoid Dendritic Cell, CD123 on CD62L + plasmacytoid Dendritic Cell and SSC-A on Plasmacytoid Dendritic Cell were found to be associated with SAH.
Conclusion
Using Mendelian randomization and meta-analysis, four inflammatory cells, one inflammatory protein, and two new gut microbiota-related pathways were shown to be connected to SAH in this investigation. suggesting that each of these could be a potential treatment target for SAH. This implies that controlling gut microbiota and using anti-inflammatory medications are essential for treating SAH.
Kyphectomy and Sliding Growing Rod Technique in patients with congenital lumbar kyphosis deformity with myelomeningocele
Authors: Karatas Muhammed Enes , Bayram Yusuf , Şafak Halid , Kar İlyas , Sağlam Necdet , Uçar Bekir Yavuz
Published: November 2023

Objective
Neural tube defects are the most common congenital disorders after cardiac anomalies. Lumbar kyphosis deformity is observed in 8–15% of these patients. This deformity severely limits the daily lives of these patients. In our study, we aimed to correct the kyphosis angle of the patients with lumbar kyphosis associated with myelomeningocele (MMC) and allow them to continue their growth without limiting their lung capacity by applying kyphectomy and sliding growing rod technique.
Patients and Methods:
In this study, we retrospectively evaluated 24 patients with congenital lumbar kyphosis deformity associated with MMC, aged between 4 and 9 years, and who applied to XXXXXX Hospital between the dates of 2018 and 2021. We evaluated preoperative and postoperative kyphosis angles, correction rates, bleeding during operations, operation time, level of instrumentation, number of the resected vertebrae, initial levels of the posterior defects, duration of hospital stays, annual lengthening, and weight of the patients.
Results
Mean age was 5.04 (between 4 and 9). Mean preoperative and early postoperative kyphosis angles were 129.8° (87–175°) and 0.79° (-20–24°), respectively. The kyphotic deformity correction rate was 99.1%. A difference was found regarding kyphosis measurements between preoperative and early period values (p < 0.05). The annual height lengthening of patients was calculated as 0.74cm/year and 0.77 cm/year between T1–T12 and T1–S1, respectively. Mean preoperative levels of hemoglobin (Hgb) was 11.95, postoperative Hgb value was 10.02 and the decrease was significant (p < 0.05). In terms of complications, 50% (12) had broken/loosen screws, 50% (12) had undergone debridement surgery, 37.5% (9) had vacuum assisted closure (VAC) therapy, and 33.3% (8) had to get all of their implants removed.
Conclusion
We believe that our sliding growing rod technique is an excellent method which makes life, rehabilitation process, and daily care easier for MMC patients with lumbar kyphosis. This technique seems to be a safe and reliable method which preserves lung capacity and allows lengthening.
Deenz Dark Triad Personality Scale: Development, Validation, and Reliability
Authors: Dar Deen Mohd
Published: November 2023

This research introduces the Deenz Dark Triad Personality Scale (DTPS-33), a 33-item instrument designed to measure Machiavellianism, Narcissism, and Psychopathy. Developed by Deen Mohd in 2015, the scale underwent content validation by psychology professors and was tested on a sample of 23 students. The study aimed to assess the reliability and validity of the scale through statistical analysis.
Association Between Social Support and Ambulance Use Among Older People in Japan: An Empirical Cross-sectional Study
Authors: Asano Yotaro , Takasugi Tomo , Ueno Keiko , Kondo Naoki , Yoshino Atsuto , Ojima Toshiyuki
Published: November 2023

Background
Ambulance service demand and utilization are increasing worldwide. To address this issue, the factors that affect ambulance use must be identified. Few studies have examined factors that can intervene and thus reduce the frequency of ambulance use. This study explored the potential association between social support and ambulance use among older adults in Japan. The findings could help improve the health of individuals by providing social support and effectively managing the growing demand for ambulances.
Methods
This cross-sectional study was conducted as part of the Japan Gerontological Evaluation Study. In December 2019 and January 2020, we collaborated with individuals aged 65 years or above with no long-term care needs. A total of 24,581 participants were included in the analysis. The objective and explanatory variables were ambulance use and social support, respectively. Binomial regression analysis was used to calculate the odds ratios (ORs) and 95% confidence intervals (CIs).
Results
Social support was associated with ambulance use. People who had no one to listen to their complaints or worries were significantly more likely to use ambulance services than those who did (OR [95% CI] = 1.26 [1.03–1.53]). People with no one to take care of them when they were ill were also significantly more likely to use ambulance services than those who had someone to provide care (1.15 [1.01–1.31]). Moreover, the results of binomial logistic regression analysis indicated that individuals who called an ambulance but were not hospitalized had significantly lower social support compared to those who did not call an ambulance.
Conclusions
The results suggest that the presence and quality of social support play a significant role in ambulance use among older adults in Japan. Our findings can help policymakers to plan and implement strategies for reducing the burden on emergency medical care.
Menstruation Disorders Related to Covid-19 Infection in Students of the Faculty of Medical and Nursing Pelita Harapan University
Authors: Natalie Angelique , Nainggolan Julita
Published: November 2023

Background: The current COVID-19 pandemic has created several problems related to the reproductive system in women, especially menstrual disorders. Changes that occur in the cycle, volume, and duration of menstruation can raise important issues, because they are indicators of the level of decline in a woman's fertility. Changes that occur in the menstrual cycle can cause reproductive problems in women, one example is fertility disorders. Considering that research on this matter is still minimal in Indonesia, the authors intend to carry out a scientific investigation of this phenomenon, so that people can better understand the impact of COVID-19 infection on the reproductive system, especially on disorders that can arise during menstruation.
Method: This study used a cross-sectional study of 198 respondents that meet the research criteria.
Results: Of the 198 respondents with inclusion criteria, it was found that 75 (37.9%) female students did not experience menstrual disorders after being infected with COVID-19 while 123 (62.1%) other female students experienced menstrual disorders. With 89 (28.7%) experiencing menstrual duration disturbances, 67 (21.6%) menstrual volume disturbances, 32 (10.3%) frequency disturbances, 32 (16.16%) menstrual regularity disturbances, 44 (14.2%) menstrual cessation disorders, and 78 (25.2%) menstrual pain disorders. Based on the Chi Square test, a p value of 0.592 was obtained so that the P Value was > 0.05 and showed that there was no relationship between COVID-19 infection and menstrual disorders.
Conclusion: There is no significant relationship between menstrual disorders and COVID-19 infection in UPH Faculty of Medicine and Nursing students
Proposal for a framework for the use of secondary data in health education
Authors: Figueiredo Francisco Winter dos Santos , Silva Bhárbara Karolline Rodrigues , Neto Luiz Sinésio Silva , Quaresma Fernando Rodrigues Peixoto , Maciel Erika da Silva
Published: November 2023

Objective
To describe the major sources of secondary data in healthcare and develop a framework for using these data in teaching.
Methods
A narrative literature search was conducted in PubMed, Scopus and the Virtual Health Library using descriptors related to teaching, secondary data and health in Portuguese, English and Spanish. In addition, through the meeting of experts and based on the articles found in the review, a unified framework of these data in teaching is created.
Results
79 studies were found, of which 14 were included after meeting the eligibility criteria. The main databases found were from the Ministry of Education, the SUS Department of Information Technology, and other sources (Institute of Health Metrics and Evaluation and Institute of Applied Economic Research) were included after a meeting with experts. The developed framework consists of three phases and 11 elements, including planning, searching and extracting data, adapting for teaching, and incorporating data for health teaching.
Conclusion
There are few data sources that can be used for health education, but those proposed are used in this framework, it is possible to transform the data into knowledge that can be transferred to teaching, taking into account teachers' knowledge of indicators, Technologies and innovations are taken into account in teaching.
Role of Fibroblast Growth Factor-23 as an Early Marker of Metabolic Bone Disease of Prematurity
Authors: Llorente-Pelayo Sandra , Docio Pablo , Arriola Silvia , Lavín-Gómez Bernardo A. , García-Unzueta María T. , Ballesteros María Ángeles , Cabero-Pérez M Jesús , González-Lamuño Domingo
Published: November 2023

Purpose: Metabolic bone disease of prematurity (MBDP) remains a significant cause of morbidity in extremely premature newborns. In high-risk patients, suspected diagnosis and subsequent treatment modifications, with limitations in terms of sensitivity and specificity, rely on low phosphorus levels and/or high levels of alkaline phosphatase (ALP). We investigatedthe potential of fibroblast growth factor-23 (FGF23) as an early marker for MBDP when measured at 3-4 weeks of life in at-risk patients.
Methods: This single-center prospective observational noninterventional study includedpreterm newborns of both sexes, with a gestational age of less than 32 weeks and/or a birth weight of less than 1500 grams. In the standard biochemical screening for MBDP performed between 3 and 4 weeks of life within a nutritional profile, the determination of FGF23 was included along with other clinical and metabolic studies.
Results: In astudy involving 25 at-risk premature newborns, 20% (n=5) were diagnosed with MBDP. Three of these patients (60%) were identified as high-risk based on biochemical evaluation at 3-4 weeks of age, while the other two patients (40%) were diagnosed in subsequent weeks. However, in all 5 patients, measurement of FGF23 levels would allow for early identification and optimization of treatment before other markers become altered. Low levels of FGF23 at 3-4 weeks, even with normal phosphorus and ALP levels, indicatethe need for modifications in nutritional supplementation.
Conclusions: MBDP remains a significant concern in extremely premature newborns. Current diagnostic techniques are limited, necessitating reliance on biochemical markers. Early detection of low FGF23 levels allows for timely treatment interventions, potentially preventing demineralization.
Multiline Orthogonal Scanning Temporal Focusing (mosTF) Microscopy for Scattering Reduction in High-speed in vivo Brain Imaging
Authors: Xue Yi , Boivin Josiah R. , Wadduwage Dushan N. , Park Jong Kang , Nedivi Elly , So Peter T. C.
Published: November 2023

Temporal focusing two-photon microscopy enables high resolution imaging of fine structures in vivo over a large volume. A limitation of temporal focusing is that signal-to-background ratio and resolution degrade rapidly with increasing imaging depth. This degradation originates from the scattered emission photons are widely distributed resulting in a strong background. We have developed Multiline Orthogonal Scanning Temporal Focusing (mosTF) microscopy that overcomes this problem. mosTF captures a sequence of images at each scan location of the excitation line, followed by a reconstruction algorithm reassigns scattered photons back to the correct scan position. We demonstrate mosTF by acquiring mice neuronal images in vivo. Our results show remarkably improvements with mosTF for in vivo brain imaging while maintaining its speed advantage.
Pan-cancer and multi-omics analyses revealed the diagnostic and prognostic value of BAZ2A in liver cancer
Authors: Liu Yan , Wang Junli , Guo Jimin , Zhang Qianyi , Wang Shuqing , Hu Fen , Wu Jinghua , Zhao Yating , Zhang Jinghua , Yu Yuan , Li Yufeng , Zhang Xiaojun
Published: November 2023

BAZ2A, an epigenetic regulatory factor that affects ribosomal RNA transcription, has been shown to be highly expressed in several cancers and promotes tumor cell migration. This study explored the expression and mechanism of BAZ2A in tumorigenesis at the pan-cancer level. The Cancer Genome Atlas, Gene Expression Omnibus databases and TIMER2.0, cBioPortal and other tools were used to analyze the level of expression of BAZ2A in various tumor tissues and to examine the relationship between BAZ2A and survival, prognosis, mutation and immune invasion. In vitro experiments were performed to assess the function of BAZ2A in cancer cells. Using combined transcriptome and proteome analysis, we examined the possible mechanism of BAZ2A in tumors. BAZ2A exhibited high expression levels in multiple tumor tissues and displayed a significant association with cancer patient prognosis. The main type of BAZ2A genetic variation in cancer is gene mutation. Downregulation of BAZ2A inhibited proliferation, migration, and invasion and promoted apoptosis in LM6 liver cancer cells. The mechanism of BAZ2A in cancer development may involve lipid metabolism. These results help expand our understanding of BAZ2A in tumorigenesis and development and suggest BAZ2A may serve as a prognostic and diagnostic factor in several cancers.
ParseGBIF: An R package for parsing species occurrence records into unique collection events
Authors: de Melo Pablo Hendrigo Alves , Bystriakova Nadia , Lucas Eve , Monro Alexandre
Published: November 2023

Biodiversity data aggregators, such as Global Biodiversity Information Facility (GBIF) suffer from inflation of the number of occurrence records when data from different databases are merged but not fully reconciled. The ParseGBIF workflow is designed to parse duplicate GBIF species occurrence records into unique collection events (gatherings) and to optimise the quality of the spatial data associated with them. ParseGBIF provides tools to verify and standardize species scientific names according to the World Checklist of Vascular Plants taxonomic backbone, and to parse duplicate records into unique ‘collection events’, in the process compiling the most informative spatial data, where more than one duplicate is available, and providing crude estimates of taxonomic and spatial data quality. When GBIF occurrence records for a medium-sized vascular plant family, the Myrtaceae, were processed by ParseGBIF, the average number of records useful for spatial analysis increased by 180%. ParseGBIF could therefore be valuable in the evaluation of species’ occurrences at the national scale in support for national biodiversity plans, identification of plant areas important for biodiversity, sample bias estimation to inform future sampling efforts, and to forecast species range shifts in response to global climate change.