bluuebunny/crossref_metadata_2025 huggingface dataset:
An Open Label Phase Ib Dose Escalation Study of TRC105 (Anti-Endoglin Antibody) with Axitinib in Patients with Metastatic Renal Cell Carcinoma
Authors: Choueiri Toni K. , Michaelson M. Dror , Posadas Edwin M. , Sonpavde Guru P. , McDermott David F. , Nixon Andrew B. , Liu Yingmiao , Yuan Zhenhua , Seon Ben K. , Walsh Meghara , Jivani Manoj A. , Adams Bonne J. , Theuer Charles P.
Published: September 2018

Background

TRC105 is an IgG1 endoglin monoclonal antibody that potentiates VEGF inhibitors in preclinical models. We assessed safety, pharmacokinetics, and antitumor activity of TRC105 in combination with axitinib in patients with metastatic renal cell carcinoma (mRCC).

Subjects, Materials, and Methods

Heavily pretreated mRCC patients were treated with TRC105 weekly (8 mg/kg and then 10 mg/kg) in combination with axitinib (initially at 5 mg b.i.d. and then escalated per patient tolerance to a maximum of 10 mg b.i.d.) until disease progression or unacceptable toxicity using a standard 3 + 3 phase I design.

Results

Eighteen patients (median number of prior therapies = 3) were treated. TRC105 dose escalation proceeded to 10 mg/kg weekly without dose-limiting toxicity. Adverse event characteristics of each drug were not increased in frequency or severity when the two drugs were administered concurrently. TRC105 and axitinib demonstrated preliminary evidence of activity, including partial responses (PR) by RECIST in 29% of patients, and median progression-free survival (11.3 months). None of the patients with PR had PR to prior first-line treatment. Lower baseline levels of osteopontin and higher baseline levels of TGF-β receptor 3 correlated with overall response rate.

Conclusion

TRC105 at 8 and 10 mg/kg weekly was well tolerated in combination with axitinib, with encouraging evidence of activity in patients with mRCC. A multicenter, randomized phase II trial of TRC105 and axitinib has recently completed enrollment (NCT01806064).

Implications for Practice

TRC105 is a monoclonal antibody to endoglin (CD105), a receptor densely expressed on proliferating endothelial cells and also on renal cancer stem cells that is implicated as a mediator of resistance to inhibitors of the VEGF pathway. In this Phase I trial, TRC105 combined safely with axitinib at the recommended single agent doses of each drug in patients with renal cell carcinoma. The combination demonstrated durable activity in a VEGF inhibitor-refractory population and modulated several angiogenic biomarkers. A randomized Phase II trial testing TRC105 in combination with axitinib in clear cell renal cell carcinoma has completed accrual.
FTIR, thermal and ionic conductivity studies of nanocomposite polymer electrolytes
Authors: Sharma Shuchi , Pathak Dinesh , Dhiman Naresh , Kumar Rajiv , Kumar Manoj
Published: September 2018

In this study, proton-conducting nanocomposite plasticized polymer electrolytes based on poly(methyl methacrylate) (PMMA) complexed with trifluoromethanesulfonic acid (HCF3SO3) plasticized with propylene carbonate (PC) and dispersed with nanosized fumed silica (SiO2) have been prepared through the solution-casting technique. The ionic conductivity of electrolytes was measured as a function of acid, plasticizer and fumed silica concentrations. A maximum ionic conductivity of 3·31 × 10−4 S/cm for PMMA + 10 wt% trifluoromethanesulfonic acid polymer electrolytes and 5·37 × 10−3 S/cm for plasticized polymer electrolytes containing 50 wt% PC has been observed at room temperature. The viscosity percolation threshold for nanocomposite polymer electrolytes was observed at 3 wt% concentration of fumed silica with ionic conductivity of 8·84 × 10−3 S/cm at room temperature. Fourier transform infrared studies suggested the complexation of constituents of the electrolytes, formation of ion aggregates in unplasticized polymer electrolytes and dissociation of ion aggregates with the addition of the plasticizer in plasticized polymer electrolytes. Differential scanning calorimetry and thermogravimetric analysis studies proved that these electrolytes are thermally stable only up to 130°C. The conductivity shows negligible change with temperature from 30 to 130°C and time of 30 d, which is desirable for their use in practical applications such solid-state batteries, fuel cells, sensors and supercapacitors.
Measuring Aggregate Housing Wealth: New Insights from an Automated Valuation Model
Authors: Gallin Joshua H. , Molloy Raven , Sommer Kamila , Nielsen Eric , Smith Paul
Published: September 2018

We construct a new measure of aggregate U.S. housing wealth based on Zillow’s Automated Valuation Model (AVM). AVMs offer advantages over other methods because they are based on recent market transaction prices, utilize large datasets which include property characteristics and local geographic variables, and are updated frequently with little lag. However, using Zillow’s AVM to measure aggregate housing wealth requires overcoming several challenges related to the representativeness of the Zillow sample. We propose methods that address these challenges and generate a new estimate of aggregate U.S. housing wealth from 2001 to 2016. This new measure provides insights into some of the disadvantages of other approaches to measuring housing wealth. Specifically, with respect to the owner valuations typically used in survey data, it appears that homeowners were slow to recognize the drop in housing wealth during the financial crisis and that their estimates of this drop were unrealistically small. At the same time, repeat-sales price indexes appear to overstate the extent of the drop in value between 2006 and 2011 and overstate the recovery thereafter.
Sanger sequencing protocol - BRCA1/2 mutations are not a common cause of malignant melanoma in the Polishpopulation v1
Authors: Dębniak Tadeusz , J Scott Rodney , Górski Bohdan , Masojć Bartłomiej , Kram Andrzej , Maleszka Romuald , Cybulski Cezary , Paszkowska-Szczur Katarzyna , Kashyap Aniruddh , Murawa Dawid , Malińska Karolina , Kiedrowicz Magdalena , Rogoża-Janiszewska Emilia
Published: September 2018

In the study we have used a standard Thermo Scientific Sanger sequencing protocol which can be found under this link: http://www.ramaciotti.unsw.edu.au/wp-content/uploads/2016/08/sequencing_handbook_FLR.pdf
1851 LONDRA SERGİSİ VE OSMANLI DEVLETİ’NİN KATILIŞI
Authors: Tekdemir Aziz
Published: September 2018

Sanayi devrimi sonrası Avrupa Devletleri’nde üretimin artması, yeni pazar ve hammadde ihtiyacını da beraberinde getirmiştir. Bu ihtiyacın giderilebilmesi için sanayi ürünlerinin ve üretim araçlarının tanıtılması amacı ile uluslararası sergiler düzenlenmeye başlanmıştır. Ayrıca bu sergilerle ülkelerin bilim, sanayi, teknoloji ve tarım alanındaki gelişme ve yeniliklerinin herkese duyurulması amaçlanmıştır. Öncülüğünü Fransa ve İngiltere’nin yaptığı sanayi sergileri, ilgili ülkelerin sömürgelerinden gelen hammadde ve bu hammaddelerden üretilen sanayi ürünlerinin pazarlanmasına yönelik olarak yapılmıştır. Başlangıçta sanayi ve ticari amaçla başlatılan sergiler, Avrupa ile Avrupa dışında bulunan devletlerin kültür ve yerel sanatları arasında, etkileşime de sebep olmuştur. 18. yüzyılın sonlarından itibaren Fransa'da ulusal düzeyde ve 19. yüzyılın ilk yarısında çeşitli Avrupa ülkelerinde düzenlenen benzer olayların doruk noktası olan Londra sergisi ilk uluslararası sergi olarak kayda geçmiştir. 1851 yılında Londra’da açılan sergi bundan sonra düzenlenen diğer uluslararası sergilere de ilham kaynağı olmuştur.
Y KUŞAĞI TEMSİLCİLERİNİN AİLE ALGILARI ÜZERİNE BİR ANALİZ
Authors: Paker Tükel İrem
Published: September 2018

Sosyal bilimler alanında, ortak zaman diliminde
yaşamanın getirisi olarak benzer özelliklere sahip bireylerin oluşturduğu
gruplar “kuşak” kavramı ile tanımlanmaktadır. Günümüzde, kuşaklar ortak bir
kabul olarak; Gelenekselciler, Bebek Patlaması, X, Y ve Z Kuşağı olarak literatürde
yer almaktadır. Ortak zaman diliminde yaşayan insanların algıları,
beklentileri, hayata bakış açıları, alışkanlıkları ve gündelik yaşam pratikleri
kendilerinden önceki ve sonraki zamanlarda yaşayanlara göre farklılık
göstermektedir. Gündelik yaşamın pratiklerinde yaşanılan değişimin en yoğun
hissedildiği alan toplumlarda genel olarak aile kurumu üzerindedir. Günümüzde,
Y Kuşağı temsilcilerinin çoğu aileleriyle bir arada yaşayan ve kendinden farklı
bir kuşağın temsilcisi olan anne babalarıyla zor iletişim kuran bireyler olarak
toplumda yer almaktadır.  Toplumu oluşturan en küçük
birim olarak tanımlanan aile, eğitim, sağlık ve güvenlik gibi bazı işlevlerini başka
kurumlara aktarmış olsa da ulusların ve kültürlerin gelişimi için temel birim
olmaya devam etmektedir. Toplumun temel yapısını oluşturan aile kurumu,
bireylerin ve toplumun gösterdiği değişime paralel bir şekilde değişmektedir.
Ailenin yapısında görülen değişimlere rağmen aile, özünde toplumun en küçük birimi
olarak kalmaya ve hem bireyler için hem de toplum için işlevini sürdürmeye
devam etmektedir. Bu çalışmada, önceki araştırmalar ve Y kuşağının temel
özellikleri dikkate alınarak bu kuşak temsilcileri için ailenin değişen anlam
ve önemine ve toplumsal yaşamda nasıl bir belirleyiciliği olduğuna
değinilmektedir.
TÜRKİYE-SURİYE İLİŞKİLERİNDE BİR KIRILMA NOKTASI: EKİM 1998 KRİZİ VEYA DİĞER BİR İFADEYLE “İLAN EDİLMEMİŞ SAVAŞ”
Authors: Gökcan Özkan
Published: September 2018

Türkiye-Suriye ilişkilerinin son 40 yıllık seyrine
baktığımızda en önemli kırılma anlardan birinin 1998 yılının Ekim ayında
yaşandığını söylemek mümkündür. 1990’lı yılların ilk yarısında imzalanan
güvenlik protokollerine rağmen Suriye’nin PKK faaliyetlerine desteğini sürdürmesi
ve Abdullah Öcalan’ın Suriye topraklarında ikamet ediyor olması, 1998
sonbaharında iki ülkeyi savaşın eşiğine getirmiştir. Ekim 1998 Krizi'nin Adana
Mutabakatı'nın imzalanması ile son bulması, iki ülke ilişkilerinde yeni bir
dönemin kapılarının aralanmasına neden olmuştur. Bu çalışmada PKK
faaliyetlerinin Türkiye-Suriye ilişkilerinde oynadığı inşa edici rol, Ekim 1998
Krizi üzerinden analiz edilmektedir. Ekim 1998 Krizi’nin Suriye yönetiminin PKK
faaliyetlerine destek vermeyeceğini resmen taahhüt ederek sonlanması, iki ülke
ilişkilerinde uzlaşmazlıktan her alanda işbirliği dönemine geçişin başlangıç
noktası olmuştur. Bu nedenle Ekim 1998 Krizi’ni bir kırılma noktası olarak
değerlendirmek mümkündür.
10 habilidades directivas. ¿Cuáles. ¿Para qué. ¿Cómo?.
Authors: Codina Jiménez Alexis
Published: September 2018

We present the results of an investigation conducted by the author to identify what they think are the ten key management skills, used for the preparation of a diploma program in this area. We analyze the areas of performance management and key skills needed in each, the logic of the skill system is proposed, why and wherefore of every one of them, as well as the specifics of the “change management” as skills. Finally, we present approaches and experiences on teaching skills.
Aproximación a los conceptos de neoconstitucionalismo y derechos fundamentales
Authors: Carrillo de la Rosa Yezid
Published: September 2018

Both first separate ones of this work propose an approach to the concept of fundamental Rights from two perspective: a methodologic one, in which they are tried to reveal the epistemologic models that from social sciences exist to approach the problematic one of the fundamental rights and, an historical one, in that it is tried to show, briefly, the most excellent moments in the formation and development of these
Aspectos internacionales del derecho a la salud
Authors: Díaz Ricardo Tatiana
Published: September 2018

This article is an advance summary of the research project called ASPECTS OF INTERNATIONAL LAW AND ARGUMENTS FOR HEALTH IN COLOMBIA. The article considers that the progress of international legislation have contributed decisively to the consolidation by way of Colombian constitutional jurisprudence of the right to health. A brief compilation of international legal instruments is made in this article
El camino hacia los derechos y libertades fundamentales en el ámbito de la unión europea
Authors: Sánchez Santana José Antonio
Published: September 2018

This study briefly exposes the road traveled by The European Union’s treaties, institutions and the battle towards the creation of a positive catalog of human rights and fundamental freedoms. As a result, the European Union Treaty’s legal referral to the Charter of Fundamental Rights elevates its status to substantive right. This significant event together with the imminent accession to the European Agreement for the defense of the human rights and fundamental freedoms has suggested the start of a new political integration cycle that leads its steps to reach the goals which have been called “Constitutional Community” by some authors.
Vigías para la democracia en Cartagena de Indias-Colombia
Authors: Navarro Díaz Luis Ricardo
Published: September 2018

This next article suggests a study of the relationship between communication and democracy based on aconcrete and authentic experience such as the youth project named Democracy Watchdogs implementedin Cartagena-Colombia, among other cities. The paper deems the young watchdog as a political citizenmeaning social, reasonable, critical, disputatious, deliberating and hence inter subjective. In relationshipwith these postulates, the democracy development, via the media, is established starting from participationprocesses as a need of Latin-American regional contexts.
La inversión extranjera directa en Colombia años 1990 - 2009
Authors: Ramírez Molinares Carlos Vicente
Published: September 2018

The present article was written based on the research study titled “Analysis of foreign investment inColombia from 1990 to 2005”, and for the purpose of the preparation of this article, a 2009 inference ismade. In Colombia, two types of foreign investment were established: direct foreign investment (DFI) andthe portfolio investment though more emphasis is made on DFI in this article with no disregard of the latterand its importance for the country.The main finding of the research lies in the fact that as from 2004 the DFI statistical data shows that it hasbeen increasing throughout the years due to the foreign countries´ confidence in the Colombian economyand progress made in terms of security.
Los principios de igualdad y reciprocidad en ofertas extranjera vs Las mipymes en contratación estatal
Authors: Pardo Posada Nohora Elena
Published: September 2018

The government’s contracting statute points out equal opportunities for those interested in governmentbidding. It honors constitutional principles of equality, transparency, swiftness, advertising among others.However, as a result of the recently passed 3809 Act of September 30th, 2009 on SMEs it could be claimedthat globalization has not yet reached this public activity’s scope.
Sistema de gestión social para pequeñas y medianas empresas
Authors: Carbal Herrera Adolfo Enrique , Blanquicett Torralvo Jesús Elías
Published: September 2018

This research study corresponds to a social management system design as a strategy seeking to improve competitiveness and assure the small and medium-sized enterprises’ sustainability. It was developed as a result of the internal and external analysis of an industry and tourism sector’s group of SMEs in the city of Cartagena. The designed structure provides the existence of a systematic and cyclic process of continuous improvement consisting of five stages: Sensibilizing, Planning, Implementing, Measuring – Valuating, Communicating and Adjusting.
Análisis histórico sobre dinámicas de ciudadanía y comunicación en la ciudad de montería durante el periodo independentista y principios del siglo XX
Authors: Garcés Prettel Miguel
Published: September 2018

This article intends to expose the Corporate Social Responsibility concept deemed as a corporate performance process in which active and passive individuals as well as the internal and external ones participate tinged by objective and subjective factors. The fundamental contribution is to call for a reflection on the contradiction between the Corporate Social Responsibility and “planned obsolescence’s” principles and the possible ways to lessen such a contradiction.
Atención en salud en la jurisprudencia constitucional. Análisis a partir de los derechos subjetivos
Authors: Díaz Ricardo Tatiana
Published: September 2018

The constitutional court through legal acts of enforcement’s rulings has developed the dynamics for the State’s compliance with its obligation with regards to the GHSSS (General Healthcare and Social Security System) users and advises, in each category of the subject in particular and according to the needs they have, on the way in which they should be served, valued and effectively protected in view of any violation of their right to public health by the stakeholders that manage the system. This work analyzes the right to health considering two special subjects: children and pregnant women.
La validez jurídica en el iusnaturalismo y el positivismo
Authors: Carrillo De La Rosa Yezid , Carrillo Ahneyenzy
Published: September 2018

This work responds to the research line on “contemporary legal issues” and is a breakthrough of the research project in place titled “ the validity problem of the current sources’ system in the Colombian law”. Even though the project’s purpose is to develop a critical assessment of the validity concept as well as study the current sources’ system in the Colombian Law following the promulgation of the 1991 Political Constitution as a step forward, this article aims only at developing the first aspect; this is the legal validity concept issue in the currents of iusnaturalist, positivist and neoconstitutionalist thoughts.
El rol del liderazgo estratégico en las organizaciones
Authors: Fierro Ulloa Isidro José
Published: September 2018

The leadership itself affects the organizations’ performance and therefore, the strategic leadership is the formulation and articulation of a vision that represents the incorporation of the strategic goals. The main goal of this article is to analyze the conceptual aspect of the strategic leadership and how it can contribute to the enhancement of the organizations’ market competitiveness. A recount of literature was conducted by gathering empirical evidence about the effect of the strategic leadership within the organizations. Based on the above, it is fair enough to conclude that the strategic leadership can pave the road and set the guidelines and goals of the organizations. At the same time, it is concluded that the strategic leadership has a positive effect on various aspects of the organizations’ competitiveness.
La creación de valor en las empresas
Authors: Ramírez Molinares Carlos Vicente , Carbal Herrera Adolfo , Zambrano Meza Ariel
Published: September 2018

For decades the goal of management was to fundamentally maximize the shareholders’ profits and equity, but due to today’s globalization of the economy, companies are forced to be managed with efficiency and effectiveness not only to just survive but also convincingly increase the company value and be competitive; it other words, it is fundamental to create value for the companies’ shareholders. In order for that to be achieved it is necessary to consider not just the benefits but also the cost incurred to generate such benefits. If the benefit is greater than the weighted average cost of capital of the resources used, it is fair to say that value has been created. Hence this article’s goal is to establish whether or not value is being added in the case study of the company OMEGA S.A., and find out if the economic value-added (EVA) is greater than cero and also determine whether the market value-added (MVA) is positive.
Acceso y movilización de personas con discapacidad físico-motriz en instituciones de educación superior Cartagena de Indias
Authors: Díaz Ricardo Tatiana , Arrieta Leottau Yanina
Published: September 2018

This is an applied research on the effectiveness of law, with theoretical and practical methodological phases. The problem that develops is the verification of the efficiency levels of laws rules that protect access to physically disabled people driving the educational institutions in the city of Cartagena, in 2011. Initial results lead us to say that in Cartagena de Indias is a high level of vulnerability of this population.
Aspectos regulatorios del consumo en Colombia: Autoridades y responsabilidades
Authors: Sayas Contreras Rafaela , Martelo Angulo Viviana de Jesús
Published: September 2018

The consumer’s right to compensation and reparation is an aspect that the United Nations has considered in the Resolution 39/248 regarding the protection of consumers in developing countries. Therefore, the aim of this article is to conduct an analysis of the Colombian consumer law in accordance with the United Nations policy on this issue. Furthermore, we show the legal means that the Colombian law has developed for consumer protection based on the Law No. 1480 of 2011, “Consumer’s Statute”, by analyzing the jurisdictional and administrative actions, as well as the shortcomings of Colombian law on this matter.
Dirección estratégica para la internacionalización de los mercados de las cooperativas
Authors: Ruiz Guerra Ignacio
Published: September 2018

For the last 20 years the cooperative sector has succumbed to the exponential growth of the commercial societies. This growth of the commercial private competition, and especially the unlimited worldwide market, fast and modern plus the technology, which is dynamic, have become a difficult area of extension for the agro-industrial cooperatives, since their priorities are mainly to secure to sell of the production, therefore they are not prepared in the event that a certain market caters for the products they cannot provide. The cooperative sector in Spain is a clear representative of the rural industry, and in many cases this is the reason of the growth in these areas, and without which, a great economical contribution would be wasted, a contribution that would be used for the maintenance of the per capita income of the inhabitants of these areas. The cooperative sector, even though it represents a minimum percentage of the worldwide market, it has theneed to expand in other international markets, and the strategy is to be based on the determinations that avoid the high quotas of risk, but this contributes to the profitability that allows the standardization of this market so they can improve their goals in times of prosperity.
Problemas ineludibles en la caracterización de los conflictos constitucionales y la ponderación de principios (Planteamiento de la cuestión)
Authors: Carrillo de la Rosa Yezid
Published: September 2018

This article reflects the advances of the research project titled “argumentation and weighting”, which intends to zero in the problems the law theorists have to tackle when defending a rational theory of weighting on its particular and universal versions. Of course, by building an advance, it shows the current status of the research and the possible lines of conceptual and theoretical development, which are necessary to bring the project to completion.
Gobierno corporativo una aproximación teórica
Authors: Portalanza Alexandra
Published: September 2018

The fate of the economical and financial world in the last decades has conditioned in a way the way the organizations are reñated to people and entities in their field. This has prompted in the organizations the need to count on corporate government systems that are effective. The purpose of this article is to document the evolution of the “corporate goverment” construct in order to contribute with the structuring of a conceptual frame that organizes knowledge. After having revised the background and concepts, related theories and groups of interest that are involved,the conclusion is that the definition of the term corporate government varies depending on the point of view and the structures and processes inside each organization. Thus one of the main goals of CG is to ensure and protect the interests of all the stakeholders in one organization.
La educación básica en Colombia
Authors: Montes Miranda Alexander Javier , Gamboa Suárez Audin Aloiso , Lago de Fernández Carmen
Published: September 2018

The reflections presented in the following article propose a discussion of educational policies related to education policies related to the quality of the basic education in Colombia. Analysis of the major theoretical concepts of the category of quality and the most relevant studies on school-quality and relationship education policy are made. To this extent, the article also shows the theoretical conceptions of basic primary education approaches, the role of teachers as a factor associated with the quality of education and the different looks of educational policy as commitment to improving the quality of education.
Responsabilidad patrimonial del estado por ataques terroristas
Authors: Sayas Contreras Rafaela , Solórzano Padilla Luis Carlos
Published: September 2018

The council of State, in several occasions and under different arguments, has declared the State asresponsible due to the damages that the victims of terrorist attacks have suffered according to the criteriaof damage imputation that range from lack of service, the damage itself or the exceptional damage. But thecriteria of damage that comes directly from the terrorist attack according to the High Court’s jurisprudence,has not always been unified especially when it is related to reparatory parameters, which, in principle onlydeal with material and moral damages, from a private law perspective. Eventually, the jurisprudence showsa tendency towards a more humanized criterion, oriented by the “integral reparation” parameters, whichtranscend the traditional guidelines of damage reparation.
Verificación del cumplimiento de las normas de tránsito por parte de los conductores de transporte público urbano en la ciudad de Cartagena, Colombia
Authors: Díaz Ricardo Tatiana , Arrieta Leottau Yanina , Mercado García Edir
Published: September 2018

This research is focused on the efficiency of the law. It analyses the conduct of the citizens with respect to the compliance of specific norms (specially the public transportation drivers in Cartagena).
This research gauges the public drivers’ compliance of the traffic norms in light of the three-dimensionality of the law, and at the same time we perform an evaluation of the citizens’ perception of the law’s institutional structure with the ultimate academic goal of contributing to increase the compliance to the law in Cartagena de Indias, Colombia.
Diagnóstico de la cadena logística de exportación del banano ecuatoriano hacia estados unidos de américa
Authors: Fierro Ulloa Isidro José , Villacres Rojas Carlos Ernesto
Published: September 2018

The current situation of the Ecuadorian banana export to the United States market is not at its best moment, limitations such as high production costs add up to the current logistic chain. This affects the situation of this sector, which is so important for the economy. Therefore, in order to improve the competitiveness of the Ecuadorian banana in the United States of America, this study focuses on a diagnosis of its weaker points in the current logistic chain through surveys and interviews given to small and medium sized exporting companies in order to avoid unnecessary intermediaries in the commercialization of the Ecuadorian banana.Such intermediaries make the final product more expensive, rendering it in a disadvantage point before other exporting countries in Central America, which have the privilege of being geographically closer to the United States of America, and whose banana has the same characteristics of the Ecuadorian banana.
Propuesta metodológica para la gestión de inventarios en una empresa de bebidas por el método justo a tiempo caso de estudio
Authors: Vélez Rojas Richard Javier , Pérez Ortega Giovanni
Published: September 2018

This article presents a methodological proposal, which aims to improve inventory management in a beverages company, using sugar as the most important raw material in this case. Because of some problems found with the supply of the aforementioned raw material, 5 phases were developed in order to guarantee an optimum inventory management, the phases are stages that explain and show the necessary conditions to develop the method, they also explain which parts are involved and what is their function in each of the project headings, plus they describe formulas that help with planning, control and appropriate execution for the project.
Mercado bursátil colombiano
Authors: León López Guillén
Published: September 2018

The purpose of this research was to determine the level of knowledge and citizen participation in Barranquilla with respect to the stock market so that we can characterize the investing profile based on complementary information in a social-economical level. The literature and the papers that analyze in a thorough way the behavior of micro-agents of the stock market are relatively scarce, therefore, the results of this research suppose and advancement in this field. The empiric enquiry and the application of a tool designed for this purpose, allowed us to identify the factors that contribute with the development and limitation of this market. The results reveal a bigger appropriation in stock market knowledge among citizens with a better financial and formative position with respect to the rest of the agents that represent meaningful backwardness. There is also an evident negative correlation between the level of income and stock investment. In this sense, the general conclusions underline the need to establish educational and financial strategies directed to promoting a better participation that promotes and generates interest on financial matters, particularly in the stock market; hence the importance of promoting training, and promotion of the financial culture and a better access to investment channels for the citizens.
Importancia de la formación del profesorado y su impacto en el proceso educativo desde la primera infancia
Authors: Múnera Cavadias Liris
Published: September 2018

This article is based on an analysis on the importance of formal education since early childhood stage. Ever since the creation of the laws that legalize this first cycle of formation, the impact of the thought and dreams of the teacher in his daily teaching routine, plus the teaching and learning views, have been vital aspects for a more humanized education.
This article is the result of the research made for the doctoral thesis, which aims to: “analyze the approaches and conceptions on training the teachers in the early stages of future Children Educators in the State Universities in the Caribbean part of Colombia”, it is a qualitative research, which uses two instruments. The first one is an adaptation of the survey made by Trigwell, and the second one is a semi-structured interview designed for such an effect, which will allow us to identify, contextualize and reflect upon the research question. The expected results are to know the pedagogic approaches and conceptions used by forming teachers.
La investigación en la enseñanza del derecho para la formación de abogados. Caso universidad de Cartagena de indias periodo 1994 – 2014
Authors: Alarcón Lora Andrés Antonio
Published: September 2018

The objective of this research is to analyze how the education provided by the teachers of the Faculty of Law and Political Sciences, University of Cartagena, has influenced the formation of the research competence of undergraduate students between 1994 and 2012; This same process will pose an analysis of the role of the teacher in the Faculty of Law and Political Science at the research training of students. So, in this article, a theoretical approach to the categories of formative research is proposed, under the curriculum design and development.
Actuaciones de las fuerzas militares generadoras de responsabilidad estatal a partir de la constitución política de 1991
Authors: Echeverría Acuña Mario Armando
Published: September 2018

The armed conflict in Colombia has transcended the legal framework due to human rights violations because of enforced disappearances, the death of civilians who were allegedly killed in battle (False Positives) and other actions that breach the IHL (massacres and enforced disappearances), in which the State through the armed forces has become responsible for the wrongful damage derived from its illegal actions. In spite of being a guarantor of the of the protection of rights. This article enquires those activities that of the armed forces that become a source of State Responsibility according to the interpretation that our Supreme Dispute Tribunal has made of the clause contained in Constitutional article 90, when they dealt with every case in concrete. For that effect, we will analyze the case-law tendency of the State Council on responsibility of the armed forces. The goal is to describe the different elements for its configuration according to differentactions of agents of the state (armed forces) as generators of responsibility.
Pleito pendiente internacional. Una mirada desde el comité de derechos humanos
Authors: González Serrano Andrés
Published: September 2018

This article tackles the element of conventional and regulatory admissibility of “no pending international lawsuit.” Due to a basic, descriptive and deductive research we obtain the results of this analysis, which allows us to answer the question “What should be understood by pending international lawsuit?” plus it allows us to understand the general goal of identifying the arguments of the Committee when a State proposes inadmissibility of communication due to the existence of a pending lawsuit. As a result, we understood that international pending lawsuit exists when there is an identity between the parties, the facts, and the rights of two international complaints and that they be in process at the same time before courts with an equivalent nature.
Diseño de un sistema de gestión en responsabilidad social empresarial para pequeños hoteles de la ciudad de Cartagena
Authors: Vergara Arrieta José Julio , Carbal Herrera Adolfo Enrique
Published: September 2018

This research paper corresponds to the design of a management system in social corporal responsibility for small hotels in Cartagena, based on the characterization and evaluation of its practices in this field, it provides a powerful tool to guide the processes of implementation of actions or activities of socio-environmental nature in these corporate units. Tourism is considered as one transcendental production betting in Bolivar due to its dynamism, job offering, wealth distribution and contribution to the regional development. This sector moves a great deal of the economy in Cartagena and many of the inhabitants depend on it directly or indirectly. However, tourism in Cartagena presents different issues that affect competitiveness and sustainability as inadequate management processes and the low availability of qualifies staff. In this sense,the corporate social responsibility plays an important role as long as it is understood as a management and commitment tool to which the corporate units adhere, allowing improvement in the dynamism of its operations and orientation of its internal processes in such a fashion that they can reach optimum levels of welfare in all the organization.For the development of this research we explored information on this topic along with fieldwork in small hotels in the city, and finally, after documentary data analysis, plus those taken directly from the reality of our subject of study, we continued to design the management system for small hotels in Cartagena.
La auditoría ambiental como función de la administración pública en la protección del bien público ambiental, para construir la empresa ecológica como meta del desarrollo sostenible
Authors: Antúnez Sánchez Alcides Francisco
Published: September 2018

This article is about environmental control through auditing as an appraising tool of the environmental management, the starting point is the scientific problem: insufficiencies in in the juridical order in terms of environmental auditing in the State sector. Its final goal is environmental control on behalf of the ecocompany and the sustainable development. Its objective is to propose theoretical arguments on environmental auditing starting from its historic, doctrinal and exegetic appraisal in order to perfect its juridical system. The methods that were implemented were the legal-theoretical, comparative law, the logic-historic, and the analytical and synthetic ones. Our techniques were surveys and interviews through questionnaires. They allowed us to assemble the present article. The main result was the proposition of theoretical arguments for perfecting the environmental auditing in the future in the state sector plus other forms of management in the social economic context. Its goal is to achieve sustainable development with the creation of eco-companies that allow balance between progress and nature.
La importancia de las técnicas de toma de notas para los estudiantes de interpretación
Authors: Fierro Ulloa Isidro José , Hinojosa Navarrete María Tatiana
Published: September 2018

This research is instructive and aims to help the interpreters to attain general knowledge about the notetaking techniques. This paper is based on the fact that in the translation classes, the teaching of note takingtechniques has not been a priority. This article suggests its inclusion in the syllabus in order to improve thecompetences of the students. First off, we need to make a diagnosis of the translation and interpretation’sstudents and alumni’s level; after a bibliographic revision was made, we determined the existing techniquesfrom which we finally propose Jean Francois Rozan’s technique. The theoretical framework presentsconcepts of the consecutive interpretation, note taking and techniques. The methodology uses the survey to15 students and 15 alumni as an instrument from the translation and interpretation program. The results ofthis research show that the students need to use one or several techniques in order to optimize their workdue to the complexity of the translation process and the different challenges they have to tackle when itcomes to do their job.
Metodología para la conversión de la información contable y financiera hacia la norma NIIF para PYMES
Authors: García Barbosa Milton Darío , Serpa de Avila Ilver
Published: September 2018

The methodology for the conversion of the accounting and financial information to the IFRS for SMEs, is supported in the Project Management Body of Knowledge (PMBOK) fifth version. The general objective of this research: to design a methodology for the conversion of the accounting and financial information to the IFRS for SMEs, based on the requirements found in the Law 1314 of 2009 and the Decree 3022 of 2014, in order that small and medium-sized enterprises (SMEs) reach international accounting standards. To achieve this objective, this research used a deductive-descriptive method that allowed researchers to make descriptive inferences; starting with general administrative and accounting processes and ending up with specific types of deductions in each of the areas of IFRS implementation for SMEs. One of the conclusions of this work establishes the importance of confronting the conversion process: applying concepts, tools and techniques of Project Management in IFRS adoption for SMEs for the first time.
La realidad del desarrollo y la contabilidad ambiental
Authors: Mantilla Pinilla Eduardo , Cabeza Rozo Mindrey Tatiana , Vargas Barajas Julieth Andrea
Published: September 2018

Since the Earth Summit in Rio de Janeiro - Brazil, 1992, “development” has been defined as meeting the human needs of the present without compromising the resources and opportunities to sustain future generations, which demands an answer to problems regarding nature, the environment, and society. Although, the new paradigm of “sustainable development” involves the eradication of poverty and the reduction of environmental harm, it is difficult to say that these are the true goals of this concept, especially when it measured predominately by economic and financial information, while ignoring social and environmental variables, as the dynamics and necessary balances. In addition, it is important to understand that the development requires conditions and processes that ensure a quality life, dignity, and social welfare, which is not clear within the sustainability concept. This situation requires theorizing the development and constructing tools for disclosure, measure, and evaluation. That is why this research is focused on what really drives the development of a nation and its context, seeking the creation of an integral conceptual framework, which incorporates variables and conditions with a social sense to solve the problem of maintaining quality life on the planet.
Impacto financiero en los contribuyentes del impuesto predial unificado ocasionado por la ausencia de regulación de gradualidad en los procesos de actualización catastral en Cartagena D.T. y C.
Authors: Martínez González Iván Ignacio , Marín Jiménez Byron Guillermo
Published: September 2018

One of the essential aspects of the economic structure of every country is taxation, which is closely related to the economy of every citizen, their socio-economic status and its role within society. This research aims to analyze the behavior of the updates of the Cadastral appraisals in recent years and to demonstrate the absence of regulation of gradualness that occurs in these processes each five years by demonstrating that in the update process the principles of equity and tax contributory capacity, includes in the constitution and law, are violated. In addition, the research aims to measure the financial impact of the tax on taxpayers, evaluating their rationality and objectivity forward the economy. The research is qualitative and quantitative, which involves the identification of the present factors, the tax effects of these processes for updating cadastral, the descriptive analysis of the techniques and procedures employed by the Agustín Codazzi Geographical Institute to perform this important work in the properties located in the district.
Evaluación de la eficiencia financiera en cuatro sectores de clase mundial
Authors: Chamorro Futinico Julio César , López Pita Manuell Guillermo
Published: September 2018

The National Development Plan 2010-2014 proposed the strengthening of new industries focus on innovation as one of the “locomotives of growth” and identified four sectors called world classes, considered strategic for Colombia, which are supported by the Productive Transformation Program (PTP) created by the CONPES 3527 and 3678 with the purpose of developing highly competitive sectors and addedvalue producers (Porter, 1990). In the period 2008-2013 the PTP presented unsatisfactory indicators and this is attributed to the existence other industries with better financial indicators that attract investment, placing large sums of capital in sectors that do not produce higher added-value as those related to mining. Therefore, the objective of this document is to assess the financial efficiency of these sectors by applying the methodology of Economic Value Added (EVA) from the operating results and their capacity to cover the cost of capital (Stern, Shiely, & Ross, 2001). The results obtained show that these sectors destroy economic added-value, due to the cost of capital, which increases with the expected rates of return for investors, considering other more profitable sectors
La escritura como una propuesta de evaluación en los programas de contaduría pública
Authors: Usme Suárez Wilson Alexis
Published: September 2018

Some accounting teachers have developed educational proposals that allow writing to be viewed as a transverse subject in accounting classes. Thus, the aim of this paper is to offer a range of strategies for writing that facilitate the development of practical skills commensurate with the needs of the current professional context. To achieve this purpose, a justification was constructed about the relevance of writing within the accounting curriculum, based on the demands of the environment and the results of research carried out in the past that demonstrates the advantages of writing for the accounting curriculum. The analysis that emerges from this work is derived from the existing background about Writing in scientific disciplines. The mail, the letter, and the auditor’s notes, among other types of writing, are the result of this reflection, which raises a dialog on the activity of writing as an accountant.
Incentivos fiscales en Brasil - una forma de ejecución de los derechos fundamentales
Authors: Rangel Rosso Rocco Antonio
Published: September 2018

When studying the complex regulatory tax in Brazil is facing a legal loophole, in regard to the legal framework and the very concept of tax incentives. Research on screen, making use of a method of qualitative analysis, using the methods of hypothetical-deductive approach of descriptive and analytical character, is the bottom line offer some basic assumptions about the normative design of the tax incentives, come to recognize the correct use of this form of state intervention in the economy, can foster the development of rights as culture, education, health, environmental sustainability, regional development, among other constitutional provisions.
La jurisdicción militar desde los fallos de la Corte Interamericana en relación con Colombia
Authors: González Serrano Andres , Meléndez Salamanca Maria Isabel
Published: September 2018

The article addresses what is the competence and scope of military criminal jurisdiction in Colombia as a State Party to the American Convention on Human Rights, and the general objective of identifying the citation niches that the Inter-American Court of Human Rights has established in relation to the question under study. The result is achieved through the development of basic, descriptive, deductive research and through the creation of a jurisprudential line, obtaining: that military jurisdiction has a restrictive and exceptional scope, and that its jurisdiction is limited only in judging active military personnel by the commission of crimes or misdemeanors that by their very nature offend against legal property of the military order.
El abastecimiento estratégico y su aplicación en las empresas
Authors: Mendoza Rivadeneira Maria Teresa , Ceballos Polanco Norman
Published: September 2018

The competitiveness generated by globalization, productivity, and recognition of supply as essential in production planning have led companies to seek new methods and procedures to provide their supply chain. The objective of this paper is to highlight the strategies implemented by different companies in this respect, with the aim of providing supplies and materials at the right time and at a lower cost. The case study of three companies was carried out and a bibliographical review of the different approaches used for the application and evaluation of the strategic supply. As a conclusion, it is set that the effects of the implementation of a strategic supply method is a factor of success in the administrative management, and its fundamental planning and study in the operation of the company.
Evaluación de la política pública de la mujer en el departamento del atlántico en el año 2013
Authors: Salcedo Díaz Laura , De los Rios Castiblanco Juan Carlos
Published: September 2018

The objective of this research is to carry out an evaluation of the public policy for women in the department of Atlántico in 2013 based on a qualitative and quantitative study with legal and political perspectives. The policy under study is called “Public Policy for gender equity and women’s rights in the department of Atlantic 2011 - 2021”. Three indicators are analyzed: impact, effectiveness, efficiency and quality of the results. The tools used are: bibliographical, context review on the problems and solutions that the public policy implies. Review of targets for efficiency and effectiveness and interviews with members of the Women’s Secretariat and representatives of the target population. Finally, it is determined that the policy is based on a perspective of individual gender violence while in application it is evidence of the dyadic, feminist approach.