bluuebunny/crossref_metadata_2025 huggingface dataset:
Isolation and Purification of an Antibiotic Polyketide JBIR-99 from the Marine Fungus Meyerozyma guilliermondii by High-Speed Counter-Current Chromatography
Authors: Wu Hankui , Liu Jianmin , Duan Ninghui , Han Ru , Zhang Xinxin , Leng Xiaoyu , Liu Wenjie , Han Liwen , Li Xiaobin , Xing Shu , Zhang Yongchun , Zhou Mingyang
Published: September 2019

JBIR-99 is a secondary metabolite of marine fungi that has been shown to possess strong antibiotic activity. An efficient approach using a combination of size exclusion chromatography with a Sephadex LH-20 and high-speed counter-current chromatography (HSCCC) has been successfully developed for the isolation and purification of a polyketide from the solid-state fermentation of Meyerozyma guilliermondii. The active compound was isolated with purity >95% by HSCCC using an optimized solvent system composed of petroleum ether–ethyl acetate– 95% ethanol–water (5:3:5:3, v/v/v/v) after size exclusion chromatography. This compound was successfully purified in the quantity of 68 mg from 120 mg of the crude extract. The structure of JBIR-99 was elucidated and assigned by 1D, 2D NMR spectroscopic, and positive HRESITOFMS. Moreover, the relative configuration of compound JBIR-99, displaying a quite complex multi-ring structure, is determined by X-ray crystallography for the first time. The purification method developed for JBIR-99 will facilitate the further investigation and development of this antibiotic agent as a lead compound. Furthermore, it is suggested that the combination of size exclusion chromatography and HSCCC could be more widely applied for the isolation and purification of polyketides from marine fungi.
Comparison of Smallest Eigenvalues for Nabla Fractional Boundary Value Problems
Authors: Jonnalagadda Jagan Mohan
Published: September 2019

In this article, we establish the existence of and then compare smallest eigenvalues for nabla fractional boundary value problems involving a fractional difference boundary condition, using the theory of u0-positive operators with respect to a cone in a Banach space.
The Association of Smoking Status and Intensity of Smoking with Blood Lipid Spectrum in a Sample of Middle-Aged Men
Authors: Alexandrov A. A. , Rozanov V. B. , Kotova M. B. , Dadaeva V. A. , Ivanova E. I.
Published: September 2019

Material and methods. A 32-year prospective cohort follow-up of males from childhood (11-12 years) was carried out. After 32 years of 1005 participants 301 (30.0%) were examined. The survey included: a survey on a standard questionnaire (passport data, the presence of bad habits [smoking, alcohol consumption]), a three-time measurement of blood pressure. The levels of total cholesterol, high and low density lipoprotein cholesterol, triglycerides were determined.

Results. There is no established relationship between the average level of total cholesterol and hypercholesterolemia with smoking status and smoking intensity. It is shown that the level of triglycerides is statistically significantly higher in smokers as compared to non-smokers. Hypertriglyceridemia was not associated with smoking status, but was associated with the smoking index in current smokers, and only with the highest values of this index in past smokers. The probability of being in a group with dyslipidemia was more than 2 times higher in smokers as compared to non-smokers. The differences in the chances of getting into a group with dyslipidemia between smokers and nonsmokers in the past were statistically insignificant. The linear dependence of the frequency of dyslipidemia on the intensity of smoking at the present time, i.e. with increasing intensity of smoking increases the frequency of dyslipidemia. Such a dependence between smoking in the past and the frequency of dyslipidemia was not revealed. The probability of being in a group with a high atherogenic risk is 2 times higher in both smokers at present and smokers in the past as compared to non-smokers. The linear dependence of the frequency of high atherogenic risk on the intensity of smoking both now and in the past is established, i.e. with the increase in the intensity of smoking the frequency of high atherogenic risk increases in both smokers at present and smokers in the past as compared to non-smokers.

Conclusion. Close association of smoking with dyslipidemia was confirmed. The high probability of being in a group with a high atherogenic risk not only in smokers at present, but also smokers in the past indicates the importance of not only secondary, but also primary prevention of smoking.
Optimization of Pharmacotherapy with Direct Oral Anticoagulants: the Need to Choose the Right Dosage Regimen
Authors: Kochetkov A. I. , Ostroumova O. D.
Published: September 2019

In recent years, there has been a persistent trend towards the more frequent prescription of direct oral anticoagulants (DOACs) compared with vitamin K antagonists due to the extensive body of evidence showing their high safety and efficacy, which in some cases exceed those of warfarin, and also by reason of there is no necessity for regular monitoring of international normalized ratio. However, the question of the reasonable and rational prescription of DOACs becomes relevant, including issues of their dosing, especially as a result of increasing in the number of patients with a complex cardiovascular risk profile and multimorbidity. In these terms, apixaban stands high among the DOAC class, and its high efficacy and safety both in full dose and reasonably reduced dosage has been proved, including older patients, patients with chronic kidney disease, coronary artery disease, with history of acute coronary syndrome and individuals undergoing percutaneous coronary intervention. This DOAC has strict indications to reduce the dose, they are specified in the drug label, and in such cases a reduced dose should be prescribed, in these clinical conditions the effectiveness and safety of apixaban is also proven. The favorable apixaban pharmacokinetic properties, consisting in low renal clearance, lack of clinically relevant interaction with food and the linear smooth effect on the blood coagulation components without episodes of hypo- and hypercoagulation, are the most important components of high efficacy and safety of this DOAC. The optimal efficacy and safety coupling of apixaban is reflected in the exclusively high patients’ adherence to the treatment confirmed by evidence-based medicine data, and therefore there is no necessity for additional procedures to maintain adherence. All the aforementioned facts allow us to recommend apixaban for widespread use in patients requiring anticoagulant therapy for optimal prevention of systemic thromboembolism and minimizing the associated risk of bleeding.
A Multivariate Analysis-Factors Related To Vascular Calcification On Regular Hemodialysis Patient; First In Indonesia
Authors: Situmorang Daniel Reinaldo P. , Muzasti Riri Andri , Nasution Syafrizal , Lubis Netty Delvrita
Published: September 2019

Introduction: Cardiovascular disease is one of the main causes of death in patients with chronic kidney disease (CKD) undergoing hemodialysis or peritoneal dialysis therapy. This is related to calcification in large blood vessels such as the aorta. Although some known coronary risk factors, such as age, dyslipidemia, diabetes and smoking, play an important role in cardiovascular disease in patients undergoing hemodialysis, but several other risk factorsy such as anemia, uremic toxins, oxidative stress, and disorders of mineral and bone metabolism also associated with CKD.Method: This study was an analytical cross-sectional study with subjects were from CKD patients who underwent regular hemodialysis (for at least 3 months) in hemodialysis unit of RSKG Rasyida Medan from May 2018 and aged > 18 years. Interviews were conducted regarding age, duration of hemodialysis. Laboratory examination of calcium, phosphate and fetuin-A levels and lateral abdominal X-ray examination were conducted, then a statistical analysis was performed to determine the relationship of these factors with blood vessel calcification in regular hemodialysis patients.Results: Of 113 subjects, duration of hemodialysis in no calcifications group was 52.09 ± 21.725, while mild grade calcification underwent HD for 51.81 ± 29.115, and severe calcification group underwent HD for 69.06 ± 36.030. A total of 10 patients without calcification had a history of DM, which were total 14 patients with calcification (mild and severe group) had history of DM. The mean serum calcium level in the group without calcification was 9,467 ± 0,843 mg / dl, 9,638 ± 0,708 mg / dl in mild group, while the average calcium level was 5,412 ± 0,645 mg / dl in severe group.Conclusion: Duration of hemodialysis, diabetes mellitus, calcium levels and fetuin-A significantly influence the occurrence of calcification in the abdominal blood vessels. (p = 0.004, p = 0.049, p = 0.005 and p = 0.004)
High prevalence of intimate partner violence among pregnant teenagers in Lira district, northern Uganda: a cross sectional study.
Authors: Auma Anna Grace , Ayebare Elizabeth , Olwit Connie , Ndeezi Grace , Nankabirwa Victoria , Tumwine James K
Published: September 2019

Background: Intimate partner violence (IPV) during pregnancy is associated with adverse health outcomes for the mother and her unborn baby. Whereas the literature on IPV in the general population is extensive, little is known about IPV among pregnant teenagers especially in resource limited settings. This study determined the prevalence and factors associated with IPV among pregnant teenagers attending antenatal care clinics (ANC) in Lira District, Northern Uganda. Methods: This was a cross-sectional study of 310 pregnant teenagers attending ANC at Lira regional referral hospital and Ogur health center IV. Eligible teenagers were recruited consecutively until the required sample size was accrued. Data was collected using a structured questionnaire. IPV was determined using the Revised Conflict Tactile Scale (CTS2) screening tool. Logistic regression analysis was performed to identify factors associated with IPV during pregnancy while considering potential confounding factors. Results: The overall prevalence of IPV among pregnant teenagers was 40.6% [95% CI: 35.13-46.34]. The prevalence of psychological violence was 37.1%, [95% CI: 31.70-42.74]; sexual assault 29%, [95% CI: 24.04-34.43] and physical violence was 24.8%, [95% CI: 20.13-30.04]. Partner alcohol intake (OR=5.00, 95%CI: 2.87-8.71, P =0.000); polygamy (OR=2.80, 95%CI: 1.49-5.23, p=0.001); and inability to make major decision in the home by the teenage mother (OR=2.42, 95%CI: 1.29-4.54: P=0.006); were independently associated with IPV during pregnancy. Conclusion: About 4 in 10 of pregnant teenagers in Lira district, Northern Uganda experience IPV. This is higher than what has been reported in the general population of pregnant women in Uganda. Teenagers were more likely to experience IPV if they were in a polygamous relationship, were unable to make major decisions in the home and had an alcoholic partner. IPV screening and counselling should be part of the routine antenatal care package. Key words; Intimate partner violence, teenage pregnancy, factors associated.
New Insights into cytotoxic metabolites produced by Streptomyces griseus isolate KJ623766: Large scale production, structure elucidation and biological activities
Authors: Zaid Ahmed S. Abu , Aleissawy Ahmed E. , Aboshanab Khaled , Yassien Mahmoud A. , Hassouna Nadia A.
Published: September 2019

Natural products particularly microbial metabolites have been the mainstay of cancer chemotherapy and are likely to provide many of the lead structures and derivatives with new biological activities. In this research, the production of some potential cytotoxic metabolites from Streptomyces (S.) griseus isolate KJ623766 was carried out in 14 L laboratory fermenter under specified optimum conditions (28°C temperature, 200 RPM rotation speed, uncontrolled PH, 3 vvm aeration and 2 bar airflow pressure). After 72 hrs of incubation, the cell free culture supernatant (CFCS) was collected and extracted using ethyl acetate (1:1, v/v) at pH 7.0. Using 3-(4,5-dimethylthazol-2-yl)-2,5-diphenyl tetrazolium-bromide (MTT) assay, the cytotoxic activity of the ethyl acetate extract against Caco2 and Hela cancer cell lines was determined with CD50 of 14 µg/ml and 20 µg/ml, respectively. Bioassay guided fractionation of the ethyl acetate extract using different chromatographic techniques had led to the purification of the cytotoxic metabolites coded W1, R1 and R2 with reproducible amounts of 20, 5, and 1.5 mg/l, respectively. The structures of respective metabolites were determined based on the mass, 1D and 2D NMR spectroscopic analysis and were identified as genistein, β-rhodomycinone and γ- rhodomycinone, respectively. Accordingly, S. griseus isolate KJ623766 can be used as a potential industrial strain for the commercial production of the isoflavonoid genistein, as well as for the production of β-and γ- rhodomycinone to be used for the construction of new derivatives with more potent cytotoxic activities of the anthracycline family. To the best of our knowledge, this is the first report about the production of the isoflavonoid genistein by S. griseus KJ623766.
Efficiency Measurement with Network DEA: An Application to Sustainable Development Goals 4
Authors: KOÇAK Deniz , TÜRE Hasan , ATAN Murat
Published: September 2019

Education is the core of the factors that
improved people for a better lifestyle and increases the level of society’
development. Quality education is one of the most vital goals of Sustainable
Development Goals (SDGs) due to actualizing these factors. Using relational
network data envelopment analysis (DEA), which have three interrelated
substages, this current paper computes the educational economy efficiency of
the Organisation for Economic Co-operation and Development (OECD) countries
bearing in mind the characteristics related to SDGs. The contribution of our
study is the use of a novel approach to computing the educational economy
efficiency using relational network DEA with GAMS. Even though some interesting
differences reveal in the efficiency of the countries, the findings show that
countries with high-efficiency scores are clustered around countries like
Latvia, Slovenia, and Korea.
Anisotropic scaling of the two-dimensional Ising model I: the torus
Authors: Hobrecht Hendrik , Hucht Fred
Published: September 2019

We present detailed calculations for the partition function and the
free energy of the finite two-dimensional square lattice Ising model
with periodic and antiperiodic boundary conditions, variable aspect
ratio, and anisotropic couplings, as well as for the corresponding
universal free energy finite-size scaling functions. Therefore, we
review the dimer mapping, as well as the interplay between its topology
and the different types of boundary conditions. As a central result, we
show how both the finite system as well as the scaling form decay into
contributions for the bulk, a characteristic finite-size part, and – if
present – the surface tension, which emerges due to at least one
antiperiodic boundary in the system. For the scaling limit we extend the
proper finite-size scaling theory to the anisotropic case and show how
this anisotropy can be absorbed into suitable scaling variables.
Diversification of export territories of family businesses as a tool of their further development
Authors: Petrů Naděžda , Tomášková Andrea , Krošláková Monika
Published: September 2019

Family business is the largest global source of jobs in the private sector, whose multigenerational nature strengthens the stability of individual economies. A competitive small and medium-sized enterprise (SME) sector into which family businesses are classified is an essential prerequisite for the full-fledged integration of any economy into the global economic space. For the Czech economy, the importance of foreign trade is increasing, and is dependent on the capabilities of companies to expand to foreign markets. The goal of this article is to identify involvement of the generation of successors to export activities of family business, focusing on diversifying export territories in relation to structure of the industry A secondary goal is to discuss the demand mechanisms for SMEs/family business oriented toward export. The scientific hypotheses defined are focused on demonstrating a dependency between the diversification of export territories, the involvement of the generation of successors in the management of the company and structure of industry. Authors have demonstrated that family businesses managed by the first generation of founders export primarily to the territories of Slovakia, Germany, and the EU. Companies where the next generation contributes to management diversify territorial risk and also export outside the EU countries. A significant correlation was demonstrated between automotive industry and Germany, Slovakia and country outside the EU and mechanical engineering and country outside the EU. The uniqueness of this article lies in the topicality of the real transition of Czech family businesses to the next generation, which carries out foreign trade to promote the further development and sustainability of the family business for future generations.
O PERFIL DOS CONSELHOS MUNICIPAIS DE EDUCAÇÃO: um estudo na região metropolitana de Belém-PA
Authors: Lima Francisco Willams Campos , Damasceno Alberto , Vale Cassio , Brito Maria Gorete Rodrigues
Published: September 2019

Objetiva-se conhecer o perfil dos Conselhos Municipais de Educação da região metropolitana de Belém - PA, a fim de compreender as condições políticas e institucionais que reúnem para desenvolver suas incumbências na gestão das políticas educacionais. Por meio de questionários aplicados foi possível identificar que tais Conselhos demonstram condições efetivas de executarem sua funções, a partir do perfil delineado e das informações obtidas junto aos sujeitos onde se pode concluir que o potencial desses colegiados pode ser determinante para a democratização da estrutura estatal
TECNOLOGIA MÓVEL E DISLEXIA: POSSIBILIDADES PEDAGÓGICAS INCLUSIVAS PELA INTERFACE DO APPMOBILE “SILABANDO”
Authors: Souza Carla Salomé Margarida de , Reis Marlene Barbosa de Freitas , Freitas Gislene De , Santos Lilian Cristina dos
Published: September 2019

Este artigo objetiva compreender a dislexia, suas características e intervenções no contexto da inclusão e das novas tecnologias. Para tanto, foi realizado uma pesquisa qualitativa em duas etapas. Na primeira, buscou-se construtos teóricos para fundamentar as concepções e intersecções da tríade: inclusão, dislexia e tecnologia móvel; na segunda, foi feito um estudo exploratório, a fim de analisar o aplicativo móvel “Silabando”. Os resultados apontam que o uso pedagógico do aplicativo analisado, pode otimizar a aprendizagem das crianças disléxicas e, consequentemente, favorecer sua inclusão.
A TRAJETÓRIA DA EDUCAÇÃO BRASILEIRA NO CONTEXTO ECONÔMICO
Authors: DE OLIVEIRA ANDRÉA MARIA DE MELO COUTO , Dusek Patricia Maria , Avelar Kátia Eliane Santos
Published: September 2019

O estudo apresenta uma breve retrospectiva da educação brasileira, no contexto econômico, ponderando as transformações educacionais e reflexo de alguns acontecimentos históricos sobre a conjuntura atual da educação. Traçou-se um paralelo entre a (re)construção das teorias econômicas e sua (des)preocupação em superar as desigualdades. Questiona-se a aplicabilidade e consequências da Emenda Constitucional 95/2016 (teto de gastos públicos) em contraponto às demandas sociais, em especial, a educação e o cumprimento das metas estabelecidas pelo Plano Nacional de Educação (PNE) 2014-2024.
AVALIAÇÃO 360º: DAS EMPRESAS DIRETO ÀS ESCOLAS DE TEMPO INTEGRAL NO ESTADO DE SÃO PAULO
Authors: Venco Selma Borghi , Mattos Rosemary
Published: September 2019

O presente artigo objetiva debater um dos aspectos da gestão do trabalho implementado pela Secretaria Estadual de Educação, no âmbito do Programa de Ensino Integral (PEI): a avaliação 360 graus, a qual integra um conjunto de procedimentos da avaliação de desempenho dos profissionais do magistério. As reflexões aqui construídas associam duas pesquisas, uma de caráter documental; e outra qualitativa, por meio de entrevistas semi-estruturadas realizadas junto a diretores.as das escolas estaduais. Constata-se que a política educacional paulista permanece coerente aos princípios gerencialistas e adota mensurações comportamentais, com vistas a enquadrar os profissionais vinculados ao Programa e adota como medida punitiva o desligamento do PEI, que bonifica em 75% os aderentes. Mesmo frente a um aumento salarial significativo, há evidências de abandono do Programa, tendo em vista as pressões vivenciadas e a desconfiguração do trabalho intelectual.
Moral and Value Orientations of Adolescents in Extracurricular Work
Authors: Козин Сергей , Kozin Sergey , Мустафина Анна , Mustafina Anna
Published: September 2019

The present paper gives a review of such terms as "value" and "extracurricular activities". Secular values are to be passed from generation to generation. Family is the most traditional means of the transfer. However, educational institutions are of equal importance, though criticized at all times and under all regimes. Therefore, school must build spiritual and moral values in schoolchildren, taking in consideration the current conditions. The authors tried to answer the question how exactly the modern school should do it. The research contains an analysis of numerous foreign and domestic scientific sources, as well as the authors’ own empirical research. The research objective was to identify the psychological and pedagogical conditions for orientation of adolescents to moral values during extracurricular activities. The empirical basis was the data obtained from a survey conducted at a secondary school (Romanovskaya Station) in 2018 (N=43). The research employed methods of analysis and synthesis. The results of theoretical and empirical research can find direct application in the educational process. They may also be useful for humanitarian departments of Russian pedagogical universities that prepare students for spiritual and moral education of students. In addition, the data can be used in the system of training and retraining of teachers.
Digital Environment as a New Challenge for University Library
Authors: Кудрина Екатерина , Rudrina Ekaterina , Ивина Карина , Ivina Karina
Published: September 2019

The research features the relevance and importance of the transition to the digital economy and digital society as the most important priorities of the state policy of the Russian Federation. The authors emphasize the impact of this process on the development of all types of libraries, including university libraries. Digital environment results in a number of social and technological challenges, e.g. the specifics of dealing with e-users of university libraries, access to electronic resources, new requirements for the publication activity of teachers and researchers in specialized sources and professional competence status, creativity of managers and specialists of university libraries, etc. The paper describes The Concept of Development of University Libraries, a draft document that emphasizes the changing role of university libraries and the need to change the content of their activities. The project takes into account the development of world libraries and such components as infrastructure, structure, and ultrastructure, including new challenges to the digital environment. The study features the case of the State University of Management that educates management personnel for libraries.
Personal Formation and Fulfillment in the Russian Socio-Cultural Environment
Authors: Золотухин Владимир , Zolotukhin Vladimir , Порхачев Василий , Porhachev Vasily
Published: September 2019

The research features ways of personal formation and fulfillment in the Russian socio-cultural space. An effective use of educational technologies contributes to personal fulfillment. Higher education helps students to socialize and adapt. Modern society requires professional competencies. However, there is a contradiction between the state demand and the requirements of modern technological management, which determines the range of problems associated with the image of a graduate that would satisfy both the state and the employers. The specifics of the use of educational technologies are significantly affected by the national mentality, which reflects the degree of impact on social and cultural policy at state and regional levels. Human potential is a reflection of the formed knowledge; it is individual and market-oriented. The problem lies in the degree of the demand for graduates on the labor market and the competencies that should be adapted to the current state of technology development in various fields of activity. The effectiveness of professional training depends on the socio-economic opportunities of the institution, its infrastructure, and opportunities to reveal the creative potential of its graduates. The higher the degree of real demand for specific specialists, the more successful and qualified will be the future specialist. If the system of competencies defines the boundaries within which the university forms the image of the future graduate, a universal graduate should possess competitive advantages, which results in the problem of a unique image of the graduate.
Procjena djelotvornosti fizioterapije i upravljanja režima pacijenata na funkcioniranje ramenog zgloba nakon implantacije ukupne reverzibilne endoproteze
Authors: Čuj Jakub , Kračmar Bronislav , Jandová Soňa , Kendrová Lucia , Nechvátal Pavol , Gajdoš Miloslav
Published: September 2019

Aim: The aim of our study was to evaluate the effect of established regime and physiotherapy treatment described by Brems on patients after reverse arthroplasty of shoulder joint, their ability to perform activities of daily living, functional status of the shoulder girdle, and a range of motion. Methods: The research sample consisted of 60 patients, 57±2.9 years, with implanted total reverse endoprosthesis of shoulder joint. To assess the ability of performing the activities of daily living, we used the Simple Shoulder Test. Functional status of shoulder joint was evaluated through a “Constant Score” questionnaire. The range of movement was evaluated through the “Constant Score – Range of Motion“ questionnaire. The examined parameters were evaluated before surgery and a month after the surgery. During the one-month post-surgery period, all participants undergone the set of targeted physiotherapy treatment and kept the established regime. After one month of targeted physiotherapeutical treatment and correct regime management we observed significant differences in all examined parameters (p<0.001). Results: After one month of post-surgery physiotherapy, significant differences in the ability to perform certain activities of daily living, functioning of the operated shoulder joint and in the range of movement, have been reported. Conclusion: The results of our study confirmed that if patients follow this specific rehabilitation protocol and cooperate during various stages of recovery, there is a high probability that after one month, they can perform activities of daily living.
Agir participativo e comunicativo: fundamentos filosóficos e legais da participação da criança e do adolescente nas políticas públicas
Authors: Zaro Jadir , Custódio André Viana
Published: September 2019

O presente artigo tem por objetivo geral analisar a participação ativa e comunicativa de crianças e adolescentes nas políticas públicas, sua fundamentação filosófica, proteção legal e importância social. Se questionando sobre quais são os fundamentos que justificam a participação ativa da criança e do adolescente na constituição das políticas públicas. Para tanto, pretende-se descrever, a partir da compreensão filosófica, o ser humano, dado com dignidade e valor individual e coletivo; aprofundar o sentido e a importância da linguagem, demonstrando seu valor instrumental e próprio; para assim, acentuar a importância do agir comunicativo e a participação da criança e do adolescente nas políticas públicas de um estado democrático de direito, que possibilita a gestão pública compartida. O método de abordagem é dedutivo e o método de procedimento monográfico com técnicas de pesquisa bibliográfica. Conclui-se que a participação da criança e do adolescente é justificada, necessária e fundamental para a elaboração de políticas públicas que contemplam as necessidades básicas da população e do Estado, de uma forma geral e mais relevante quando essas estão voltadas para os cidadãos e sujeitos em processo de desenvolvimento.
The Effectiveness of Telerehabilitation as a Supplement to Rehabilitation in Patients After Total Knee or Hip Replacement: Randomized Controlled Trial
Authors: Eichler Sarah , Salzwedel Annett , Rabe Sophie , Mueller Steffen , Mayer Frank , Wochatz Monique , Hadzic Miralem , John Michael , Wegscheider Karl , Völler Heinz
Published: September 2019

Background

Telerehabilitation can contribute to the maintenance of successful rehabilitation regardless of location and time. The aim of this study was to investigate a specific three-month interactive telerehabilitation routine regarding its effectiveness in assisting patients with physical functionality and with returning to work compared to typical aftercare.

Objective

The aim of the study was to investigate a specific three-month interactive telerehabilitation with regard to effectiveness in functioning and return to work compared to usual aftercare.

Methods

From August 2016 to December 2017, 111 patients (mean 54.9 years old; SD 6.8; 54.3% female) with hip or knee replacement were enrolled in the randomized controlled trial. At discharge from inpatient rehabilitation and after three months, their distance in the 6-minute walk test was assessed as the primary endpoint. Other functional parameters, including health related quality of life, pain, and time to return to work, were secondary endpoints.

Results

Patients in the intervention group performed telerehabilitation for an average of 55.0 minutes (SD 9.2) per week. Adherence was high, at over 75%, until the 7th week of the three-month intervention phase. Almost all the patients and therapists used the communication options. Both the intervention group (average difference 88.3 m; SD 57.7; P=.95) and the control group (average difference 79.6 m; SD 48.7; P=.95) increased their distance in the 6-minute-walk-test. Improvements in other functional parameters, as well as in quality of life and pain, were achieved in both groups. The higher proportion of working patients in the intervention group (64.6%; P=.01) versus the control group (46.2%) is of note.

Conclusions

The effect of the investigated telerehabilitation therapy in patients following knee or hip replacement was equivalent to the usual aftercare in terms of functional testing, quality of life, and pain. Since a significantly higher return-to-work rate could be achieved, this therapy might be a promising supplement to established aftercare.

Trial Registration

German Clinical Trials Register DRKS00010009; https://www.drks.de/drks_web/navigate.do? navigationId=trial.HTML&TRIAL_ID=DRKS00010009
Issues in the financing and provision of Orthotics and Prosthetics services in Iran: Protocol for a Qualitative Research Study (Preprint)
Authors: Shahabi Saeed , Ahmadi Ahmad , Shabaninejad Hosein
Published: September 2019

BACKGROUND

The demand for rehabilitation services, including Orthotics and prosthetics services, is increasing. Traffic injuries, Eight-years imposed war, natural disasters, aging, and chronic diseases are the main causes of disability in Iran that lead to the great need for receiving these services. This study will attempt to identify the challenges in the financing and provision of Orthotics and Prosthetics services in Iran and declare the policy solutions to improve the financing and delivery of these services in line with the universal health coverage.

OBJECTIVE

This study aims to explore the challenges in the financing and provision of the Orthotics and Prosthetics services in Iran and propose policy solutions to strengthen this sector.

METHODS

This study will use the qualitative content analysis method for understanding the challenges. The study population of this study will be all clinicians, academics, and policy-makers who involved in the financing and provision of the Orthotics and Prosthetics services. The purposeful sampling, as well as the snowball sampling, will be used to select the informants. The individual face-to-face semi-structured interviews will be conducted in Tehran, Isfahan, and Shiraz. Furthermore, telephone and Skype interviews will be applied to participants who lived in other regions. This project will be performed from 2019 to 2020.

RESULTS

We believe the results will lead to identifying challenges and also policy solutions to strengthen the Orthotics and Prosthetics services in the healthcare system and improve the utilization in Iran.

CONCLUSIONS

The findings will inform the policy-makers to better planning in Iran and internationally.
A User-Friendly, Web-Based Integrative Tool (ESurv) for Survival Analysis: Development and Validation Study (Preprint)
Authors: Pak Kyoungjune , Oh Sae-Ock , Goh Tae Sik , Heo Hye Jin , Han Myoung-Eun , Jeong Dae Cheon , Lee Chi-Seung , Sun Hokeun , Kang Junho , Choi Suji , Lee Soohwan , Kwon Eun Jung , Kang Ji Wan , Kim Yun Hak
Published: September 2019

BACKGROUND

Prognostic genes or gene signatures have been widely used to predict patient survival and aid in making decisions pertaining to therapeutic actions. Although some web-based survival analysis tools have been developed, they have several limitations.

OBJECTIVE

Taking these limitations into account, we developed ESurv (Easy, Effective, and Excellent Survival analysis tool), a web-based tool that can perform advanced survival analyses using user-derived data or data from The Cancer Genome Atlas (TCGA). Users can conduct univariate analyses and grouped variable selections using multiomics data from TCGA.

METHODS

We used R to code survival analyses based on multiomics data from TCGA. To perform these analyses, we excluded patients and genes that had insufficient information. Clinical variables were classified as 0 and 1 when there were two categories (for example, chemotherapy: no or yes), and dummy variables were used where features had 3 or more outcomes (for example, with respect to laterality: right, left, or bilateral).

RESULTS

Through univariate analyses, ESurv can identify the prognostic significance for single genes using the survival curve (median or optimal cutoff), area under the curve (AUC) with C statistics, and receiver operating characteristics (ROC). Users can obtain prognostic variable signatures based on multiomics data from clinical variables or grouped variable selections (lasso, elastic net regularization, and network-regularized high-dimensional Cox-regression) and select the same outputs as above. In addition, users can create custom gene signatures for specific cancers using various genes of interest. One of the most important functions of ESurv is that users can perform all survival analyses using their own data.

CONCLUSIONS

Using advanced statistical techniques suitable for high-dimensional data, including genetic data, and integrated survival analysis, ESurv overcomes the limitations of previous web-based tools and will help biomedical researchers easily perform complex survival analyses.
A web-based system for booking patients for hospital admission to the orthopedic department (Preprint)
Authors: Dabrowski Mikolaj , Kubaszewski Lukasz
Published: September 2019

BACKGROUND

Poor management efficiency in the Polish health system requires the use of patient information systems that have been in operation for several years. However, their heterogeneity and technological and functional diversity pose a challenge. Not only do systems of different companies differ from each other, but within the same solution, there are shortcomings or differences in functional modules across different units of the health sector. These are due to variations in demands related to the specifics of the unit.

OBJECTIVE

Therefore, the lack of appropriate tools for planning patient admissions in the present hospital information system, the current failure of paper management methods, and the lack of tools at the ready to create our own have forced the implementation of commercial solutions.

METHODS

An Admission of Patient Program based on the browser is available on devices connected only to the hospital network. The program used the online FullCalendar library and the MySQL database.

RESULTS

The system is based on the form of a calendar with the possibility of editing a patient's records planned for a given day of admission. It is intuitive and easy to use. It is a transparent program, thanks to the use of color styles in the records.

CONCLUSIONS

Conclusions. After 2 years, the system works efficiently and is a significant facilitator of the management of patient admission planning, which translates into the appropriate use of branch resources (number of staff and hospital beds) and optimization of operating room usage.
CORRUPCIÓN Y DERECHOS HUMANOS EN LA ONU, EN SUS COLABORADORES Y EN SUS VIGILANTES
CORRUPTION AND HUMAN RIGHTS IN THE UN, IN ITS COLLABORATORS AND IN ITS WATCHERS
Authors: Quinteiro Maria Esther Martínez
Published: September 2019

La ONU, que contempla entre sus misiones la de luchar contra la  corrupción, fundó, el 14 de julio de 1997, la Oficina de Naciones Unidas contra la Droga y el Delito (UNODC), cuyo objetivo es  luchar contra las drogas y las múltiples manifestacio-nes del crimen organizado transnacional, la corrupción y la prevención del terrorismo. Seis años después, la Asamblea General de la ONU aprobó  (Resolución 58/4. 2003) su primer instrumento jurídicamente vinculante para combatir dicha lacra: la  Convención de las Naciones Unidas Contra la Corrupción, que entró en vigor en diciembre de 2005. Se  confió   su desarrollo a Expertos y Grupos de Trabajo creados ad hoc, encargándose velar por su aplicación y asegurar su control a la  bienal Conferencia  de los Estados  Parte, de carácter intergubernamental.  Dada la frecuente  dimensión transnacional de la corrupción o la no menos frecuente impunidad de la corrupción local allí donde los funcionarios carecen de controles internacionales, la iniciativa parece a todas luces necesaria  y  plausible.  Desgraciadamente la eficacia de este mecanismo es relativa y su fiabilidad escasa dado que la ONU misma, sus funcionarios, sus colaboradores  de la sociedad civil y hasta ciertas organizaciones autoerigidas en  sus "vigilantes", no se libran de la corrupción que  pretenden  perseguir. Esto  redunda en la erosión de los Derechos Humanos.
Procedimientos poéticos y figuraciones autoficcionales en los biodramas de Vivi Tellas: estudio de casos
Authors: Tossi Mauricio
Published: September 2019

El impacto de las producciones escénicas e intelectuales de Vivi Tellas han generado diversos modelos de gestión y creación, los que funcionan como marcos de referencia en el teatro de Buenos Aires y en otros campos artísticos de la región. Ante la multiplicidad de lecturas que estas creaciones escénicas promueven, en este artículo analizaremos los procedimientos y las figuraciones autoficcionales de tres obras definidas por Tellas como “biodramáticas”. Desde nuestra perspectiva, este análisis procedimental permitirá, por un lado, comprender sus configuraciones poéticas y subjetivas, por otro, generar fuentes para un estudio comparado con otras modalidades interregionales del teatro documental y autoficcional.
Peningkatan Hasil Belajar Mawaris Melalui Pembelajaran Kooperatif Tipe Jigsaw
Authors: Ramadhan Tu
Published: September 2019

The learning of Islamic Religious Education (PAI) in the class is less activity of the students because the learning strategy is dominated by the teacher, and there is no varied learning strategy, then the choice that can be done to solve this problem is with the use of cooperative type jigsaw in learning subjects Islamic Religious Education as well as conducting classroom action research. This study aims to find out how the activities of teachers and students in learning subjects Islamic Religious Education (PAI) discussion of inheritance with the use of cooperative type jigsaw on twelve students, Natural Science State High School one Kutamakmur, and to find out how to improve learning outcomes. This research uses a qualitative approach with the class action research method (PTK) and using data collection instrument through observation, test, diary, documentation and analyzed by reducing data, describe and conclude. And the subject of the research is the teacher of Islamic Religious Education who teaches mawaris material through the cooperative strategy of jigsaw type and students of class XII IPA.1 SMA Negeri 1 Kutamakmur academic year 2016/2017 second semester of 25 students. The results showed an increase: (1) In the first cycle of teacher activity 52%, then increased to 70% in cycle II, and the third cycle increased to 84%, (2) Student activity in the first cycle was 47%, then increased in cycle II to 68%, and on the third cycle increased to 83%, (3) student learning outcomes in cycle I was 10 students completed (40%), then in cycle II increased 16 students complete (64%), and cycle III increased to all students complete (100%).
Pengembangan Media E-Learning Interaktif Dalam Menyongsong Revolusi Industri 4.0 Pada Materi Ekosistem Untuk Siswa SMA
Authors: Sadikin Ali , Hakim Nasrul
Published: September 2019

Abstract. Electronic based biology learning media is important to be developed to meet students' needs for the development of the industrial revolution 4.0. The purpose of this research is to produce a product that consists of Web-based interactive e-learning media. The research method uses Research & Development (R&D) with ADDIE models (analysis, Design, Development, Implementation, and Evaluation). Measuring instruments used in this study were questionnaires given to validators and when testing small groups and large groups. In this study using qualitative data analysis from the results of the questionnaire which was then asked quantitatively. The results showed that the media validator and material validator were worth mentioning by the media to be tested. After being tested in small groups, students get a score of 80% (good) and in trials large groups get a score of 80.74% (good). While subject matter teachers gave a score of 80.76% (good). Thus it can be concluded that the responses of students and teachers to interactive e-learning media products based on web ecosystem material are included in the criteria both in accordance with the industrial revolution 4.0. So that students can learn and use interactive e-learning media anywhere and anytime to facilitate learning. For further research it is recommended for other educational materials and levels.

Keywords: Media e-learning, Web, industrial revolution 4.0, Ecosystem

Abstrak. Media pembelajaran biologi berbasis elektronik penting dikembangkan untuk memenuhi kebutuhan siswa seiring perkembangan revolusi industri 4.0. Tujuan penelitian ini adalah menghasilkan produk berupa media e-learning interaktif berbasis Web. Metode penelitian menggunakan Research & Development (R&D) dengan model ADDIE (analysis, Design, Development, Implementation, dan Evaluation). Alat ukur yang digunakan dalam riset ini adalah kuesioner yang diberikan kepada validator dan saat uji kelompok kecil dan kelompok besar. Dalam penelitian ini menggunakan analisis data kualitatif dari hasil kuesioner lalu ditafsirkan secara kuantitatif. Hasil penelitian menunjukkan bahwa validator media dan validator materi menyatakan layak media ini untuk diujicobakan. Setelah diujicoba pada kelompok kecil pada siswa mendapatkan skor 80% (baik) dan pada uji coba kelompok besar mendapat skor 80,74% (baik). Sementara guru bidang studi memberikan skor 80,76% (baik). Dengan demikian dapat disimpulkan bahwa respon siswa dan guru terhadap produk media e-learning interaktif berbasis web pada materi ekosistem termasuk dalam kriteria baik sesuai dengan revolusi industri 4.0. Peneliti menyarankan agar siswa dan menggunakan media e-learning interaktif dimana dan kapan saja untuk memudahkan belajar. Untuk penelitian selanjutnnya disarankan untuk materi dan jenjang pendidikan yang lain .

Kata Kunci : Media e-learning, Web, revolusi industri 4.0, Ekosistem
Reflexiones sobre Diseño, Arte y Tecnología
Authors: Di Bella Daniela Viviana
Published: September 2019

Este texto presenta de manera sintética una serie de reflexiones acerca de la relación dialógica que se manifiesta en las décadas recientes entre el Diseño, el Arte y la Tecnología, entendidos como territorios de acción, frente a la relación de dependencia-independencia de tipo pendular propia del arte y el diseño. La modificación operada por la revolución digital es uno de los determinantes del posible corrimiento de los límites disciplinares, además de ser contexto y parte de la emergencia de un nuevo paradigma cultural, fértil para el desarrollo de un nuevo espacio de experimentación conceptual y prácticas intermediales.
Re-encanto do concreto por sistemas enativos afetivos: a naturalização das tecnologias no ecossistema.
Authors: Domingues Diana Maria Gallicchio
Published: September 2019

ResumoNeste ensaio, num aporte retroprospectivo, condenso especificidades de produções anteriores e esboço projetos em desenvolvimento que apontam para tecnologias criativas e inovação disruptiva com sistemas enativos afetivos, numa estreita e mútua relação ou reciprocidade entre o biológico, dados e o ambiente. Trata-se de um ecossistema que reconfigura o conceito de “vivo” ou a transformation du vivant, apontado por Poissant e Daubner (2012). São geradas formas de vida que ampliam tecnologias anteriores, configurando inovações disruptivas, pois se misturam a modos de viver no cotidiano com os avanços das tecnologias, principalmente pelos dispositivos móveis e sistemas de sensoriamento e processamento de sinais. Este ensaio é construído por alguns fragmentos publicados, que demarcam meu posicionamento científico e estético-antropológico, sempre com tecnologias criativas e os modos de pensar a arte mesclada à vida com sistemas que re-encantam o concreto.AbstractIn this essay, in a retrospective approach, it condenses specificities of previous productions and outlines projects under development that point to creative technologies and disruptive innovation with affective enactive systems, in a close and mutual relationship or reciprocity between biological, data and the environment. It is an ecosystem that reconfigures the concept of “living” or the transformation “du vivant”, pointed by Poissant and Daubner (2012). Life forms are generated that amplify previous technologies, configuring disruptive innovations, as they blend with everyday ways of living with the advances of technologies, mainly by mobile devices and sensing and signal processing systems. This essay is built by some published fragments, which demarcate my scientific and aesthetic-anthropological positioning, always with creative technologies and ways of thinking art mixed with life with systems that re-enchant the concrete.