bluuebunny/crossref_metadata_2025 huggingface dataset:
Characterization of Rosemary (Salvia rosmarinus) Essential Oil Obtained by Solvent-Free Microwave Extraction with Kombucha Tea (Anthriscus sylvestris L.) Produced by Adding Guava (Psidium guajava L.) Peel and Pulp
Authors: Yangılar Filiz , Gerek Merve Dilara
Published: January 2025

The study aimed to evaluate the potential of creating a functional beverage by enriching Anthriscus sylvestris (L.) kombucha production with guava peel and pulp, showcasing the variety and richness of the product formulations. This was done due to kombucha being a fermented beverage rich in various bioactive compounds that have significant effects on health and the possibility of enhancing product diversity through different formulations. Thus, the kombucha tea was physicochemical, phytochemical, antioxidant activity, and sensory evaluation during the 15-day fermentation period. The increased acetic acid bacteria and yeast count indicates that Anthriscus sylvestris is a viable substrate for the proliferation of Kombucha symbiotic microbes. Adding guava peel and rosemary oil to kombucha significantly increased its total phenolic, flavonoid, and vitamin C content (P<0.05). Anthriscus sylvestris-guava kombucha has antibacterial properties (zones of inhibition of 18.32 and 17.31 mm against Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922, respectively). Moreover, it also provided an inhibitory effect on α-glucosidase and α-amylase, enzymes associated with diabetes. The DPPH, ABTS*+, FRAP, CUPRAC, and ORAC capacities were found to be 66.89-78.90%, 70.83-97.25%, 367-723.15 μmol Trolox/mL, 381.40-460.45 μmol Trolox/mL, and 486.50-737.50 μmol Trolox/mL, respectively. Anthriscus sylvestris kombucha has well-balanced and pleasant sensory properties. These findings indicate that preparing Anthriscus sylvestris kombucha tea with guava may have health effects and that further research is needed to determine potential health benefits.
Nitrogen Fertilization Effects on Oil Content, Sucrose, α- Tocopherol, Fatty Acid and Aminoacid Compositions of Confectionary Sunflower Seed
Authors: Canavar Öner , Gören Hatice Kübra
Published: January 2025

This study investigates the effects of nitrogen fertilization on the composition of confectionary sunflower seeds, including parameters such as oil content, alpha-tocopherol, sucrose, amino acids and fatty acid composition. Nitrogen fertilization, surprisingly, had no significant effect on sunflower oil content, with remarkable differences observed between the genotypes. The α-tocopherol content, an important antioxidant, displayed responses that were dependent on the genotype upon application of nitrogen. The Somon Beyazı genotype consistently demonstrated higher oil content compared to the Ahmet Bey genotype. In addition, both genotypes showed a decrease in α-tocopherol levels as the application of nitrogen increased. Sucrose content was higher in the Somon Beyazı genotype and decreased significantly with increasing nitrogen doses. Significant variations were observed in fatty acid compositions, further emphasizing the impact of genotype and nitrogen application. The study also revealed diverse amino acid profiles, with notable concentrations of glutamine and asparagine. This comprehensive study highlights the complex interaction between genotype and nitrogen fertilization and provides valuable insights for optimising sunflower seed production and quality. The results emphasise the significance of integrating both genetic factors and nutrient management practices into crop cultivation for improved agricultural outcomes.
Assessment of the Effects of Organic Fertilizer Applications on the Biochemical Quality of Basil
Authors: Özbucak Tuğba , Ocak Meltem , Çol Ayvaz Melek , Ertürk Ömer
Published: January 2025

It is important to characterize the biochemical potential of medicinal and aromatic plants, which have significant therapeutic and commercial value. However, fertilizers obtained from natural resources are used in sustainable agricultural practices. In this study, basil (Ocimum basilicum L.) was grown from seed with different doses of barnyard manure, vermicompost and chicken manure were added. This work aimed was to investigate and compared the effect of these different fertilizer doses applications on the biochemical potential of basil plants.
Total phenolic content, antioxidant capacity and antimicrobial activity values were statistically significant according to the type and doses of fertilizer studied. Linalool was found to be the highest amount of volatile compound in leaf samples of manure treated plants. The highest antioxidant capacity values were determined in the samples where farm manure and chicken manure were applied at low (2.5%) and medium (20%) doses and worm manure was applied at high doses. The highest antibacterial effect was detected in the essential oil extract of leaf samples with 10% vermicompost against Bacillus cereus. Among the Gram (-) bacteria, the highest antibacterial effect against E. coli was determined in the essential oil extract of leaf samples with 20% farm manure. The essential oil extract of leaf samples with 20% farm manure also showed significant and high degree of antifungal effect against S. cerevisae.
Environmental and Ecological Risks Posed by Sediment Heavy Metals in Reservoirs: A Preliminary Study from Northwest Türkiye
Authors: Tekiner Murat , Tunçay Tülay , Parlak Mehmet
Published: January 2025

Reservoir sediments are an important component of aquatic ecosystems. Concentrations, sources, pollution and ecological risks of heavy metals pose serious risks on sustainable management of these ecosystems. This research focuses on heavy metal contents, physicochemical properties, environmental and ecological risks of sediments in four reservoirs (Ayvacık, Bayramdere, Bayramiç, and Umurbey) in Northwest Türkiye. Bayramiç reservoir had greater sediment Al, Cu, Fe, Mn concentrations, clay and silt contents than the other reservoirs (Ayvacık, Bayramdere, and Umurbey). In all four reservoirs, sediment heavy metals were generally of natural origin. Although sediment pollution index was identified as “considerable contamination” for Mn, such a case was not detected for the other heavy metals (Cd, Co, Cr, Cu, Fe, Ni, Pb, and Zn). An ecological risk assessment was made for reservoir sediments and a “low contamination” was detected.
Blocking effect of double-row periodic pile barriers on vibration waves
Authors: Ding Guangya , Bao Junqi , Zhu Lei , Wu Ming
Published: January 2025

With the rapid development of China’s transportation, the problem of environmental vibration is becoming increasingly prominent, and the traffic lines are inevitably close to the building, and the environmental vibration caused by it has a serious negative impact on the safety of the building, the use of precision instruments and the physical and mental health of residents. In this study, the vibration damping barrier is designed periodically, and its unique band gap characteristics can be used to perform directional vibration damping in specific vibration reduction frequency bands. In this paper, the band gap of the periodic row piles is calculated by the periodic theory, and then the measured attenuation domain characteristics of the periodic row piles in the bandgap frequency band are verified by indoor model tests, and the effects of the length of the concrete row piles, the row spacing, the train speed and the load on the vibration isolation effect are discussed. The results show that with the increase of pile length, the vibration isolation effect gradually increases, in addition, the larger row spacing will reduce the vibration isolation effect, and the increase of train speed and amplitude will also lead to poor vibration isolation effect. This study provides a useful reference for the application of concrete row piles in practical engineering.
Estrategias de acción para el fomento de competencias en derechos sexuales y reproductivos en población adolescente
Authors:   Universidad Cooperativa de Colombia, Cárdenas Quintero Alba Patricia
Published: January 2025

Esta guía práctica está concebida para que los estudiantes- de práctica en Psicología Educativa aborden temas de derechos humanos sexuales y reproductivos en los espacios escolares con estudiantes adolescentes a través de una construcción individual de conocimientos, habilidades, valores y actitudes que fortalezcan su proyecto de vida a lo largo de su trayectoria escolar. Este abordaje se puede llevar a cabo en las aulas de clase o con grupos focales con un número no mayor a diez estudiantes. Por tal razón, en el presente documento se entregarán los lineamientos que establece la labor práctica en función de formar a los jóvenes en temas de sexualidad.
Congelación de células v1
Authors: Garcia Judit
Published: January 2025

Congelar células en crioviales para preservarlas durante largos periodos de tiempo manteniendo la viabilidad. NOTA: Se puede proceder a la congelación cuando el cultivo esté en fase logarítmica de crecimiento con una confluencia alrededor del 80%.
Rapid multiplexed nanopore amplicon sequencing of Plasmodium falciparum microhaplotype loci v1
Authors: Holzschuh Aurel
Published: January 2025

This protocol outlines a multiplexed nanopore amplicon sequencing (AmpSeq) panel targeting six highly diverse P. falciparum microhaplotype loci. For a detailed explanation of the data analysis, please refer to our pre-print and github repository. An example workflow of the bioinformatics pipeline and haplotype inference code used in the pre-print can be found on zenodo.
Inhibitor-free DNA extraction from unsorted bulk samples v1
Authors: Buchner Dominik , Borowski Marie
Published: January 2025

This protocol describes how to extract inhibitor-free DNA from unsorted, homogenized bulk samples. of homogenate can be processed in one extraction, but there is also a miniaturized version for of input material, if less DNA is required. The protocol is based on the DNeasy PowerMax Soil Kit but costs much less. A lot of the buffers can be found in the following patent https://patents.google.com/patent/US7459548B2/en
Plantas medicinales y predictibilidad de uso en algunas veredas del corregimiento de San Cristóbal (Antioquia), Colombia
Authors: Vera-Marín Bladimir , Sánchez-Sáenz Mauricio
Published: January 2025

Durante un periodo de siete meses y con la colaboración de dos conocedores se realizó un registro de plantas medicinales del Corregimiento de San Cristóbal, ejecutándose el inventario de las mismas en tres veredas de la localidad e identificándose un total de 105 especies pertenecientes a 43 familias. El objetivo principal del estudio fue determinar la posibilidad de anticipar el uso medicinal de una especie de planta, si se conoce la familia botánica a la cual pertenece la misma. Mediante un análisis de cluster se estableció la relación entre la familia botánica y el tipo de uso medicinal asignado, conformándose siete grupos de familias asociado cada uno a un conjunto particular de categorías médicas. La relación familia botánica-categoría de uso medicinal establecida, demuestra que una planta en particular puede ser utilizada para diversos fines medicinales. Se concluye que no es posible predecir solo un uso, sino un conjunto de usos medicinales de una planta si se conoce la familia botánica a la cual pertenece. En la zona estudiada, al igual que en otras tierras altas de Suramérica, las familias con uso medicinal mejor representadas, de acuerdo al número de especies y por citación de los colaboradores locales, en general son las mismas, siendo las principales: Asteraceae, Lamiaceae, Apiaceae y Solanaceae.
Nuevos registros de macromicetos para Colombia
Authors: Lombana-Álvarez Paola , Moterroza-Álvarez Jorge A. , Chamorro-Quiroz Luis F. , Franco-Molano Ana E. , Payares-Díaz Iris R.
Published: January 2025

Se presentan los resultados del trabajo realizado en la Estación Meteorológica de CARSUCRE, en bosque seco tropical del municipio de Colosó, departamento de Sucre (Colombia), donde se efectuaron transectos lineales de 100 m al lado del arroyo Sereno y parte alta del bosque (cerro), durante los meses de febrero-agosto y noviembre del año 2011, se realizaron un total de 182 colecciones, distribuidas en los filos Ascomycota (4 géneros y 11 especies) y Basidiomycota (31 géneros con 59 especies), se logró recolectar 39 registros nuevos para Sucre y siete para Colombia. Este trabajo constituye un estudio pionero para el departamento de Sucre, debido a que no existe información acerca de los hongos silvestres presentes en el bosque seco tropical (Bs-T).
Señalización Sonic Hedgehog (SHH) en el cerebro adulto: vía crucial para la reactivación de los astrocitos y la reparación del cerebro
Authors: Bermúdez-Muñoz Olga M.
Published: January 2025

Mientras que las neuronas juegan un papel fundamental en la neurotransmisión en el sistema nervioso central de los animales, las células gliales son cruciales para dar sostén a las neuronas y por lo tanto, para el funcionamiento del cerebro. Estudios recientes han puesto de manifiesto que las células gliales regulan la liberación y reciclaje de neurotransmisores, el metabolismo del piruvato y del glutatión, sirviendo de tampón para diferentes iones, participando en la organización de la barrera hematoencefálica y en la producción de mielina y del líquido cefalorraquídeo. La actividad de las células gliales se encuentra estrechamente coordinada por la comunicación entre las neuronas y la glía. Entre la señalización celular del cerebro, la vía Sonic Hedgehog (SHH) juega un papel importante al regular el desarrollo y patrón del sistema nervioso central. En el cerebro adulto, la proteína SHH es secretada por las neuronas y por los astrocitos y media de esa manera las interacciones neuro-gliales. Cuando ocurre un daño en el cerebro, la vía de señalización SHH es (re)-activada en el cerebro adulto. Las células gliales y particularmente los astrocitos, son células esenciales para la respuesta del cerebro frente a un daño y para su reparación. La respuesta de los astrocitos se encuentra mediada por la activación de la vía SHH en estas células. En este artículo se revisa la importancia de las células gliales y específicamente de los astrocitos en la fisiología del cerebro, la implicación de la vía de señalización SHH en la organización y funcionamiento del cerebro, y cómo la señalización SHH regula la re-activación de los astrocitos y la respuesta celular frente al daño tisular y a la reparación del cerebro en el organismo adulto.
Tuberculosis meníngea: detección y caracterización de antígenos específicos de mycobacterium tuberculosis en líquido cefalorraquídeo
Authors: Pino Paula , Volcy Mitchel , Franco Andrés , Uribe Carlos , Guzmán Angela , Restrepo Blanca , Robledo Jaime
Published: January 2025

La tuberculosis meníngea (TBM) es la causa más importante de meningitis crónica mundialmente. Se diagnostica demostrando Mycobacterium tuberculosis en líquido cefalorraquídeo (LCR) por directo y cultivo, ambos poco sensibles (0-25%, 25-86%, respectivamente) (1). Estas dificultades han llevado a buscar métodos diagnósticos más sensibles, de bajo costo y fácil implementación. Se han caracterizado algunos antígenos específicos de M. tuberculosis: ESAT-6, complejo 85, proteína de 38 kDa, lfacristalina(2) y CFP-10 (3), los cuales podrían tener potencial iagnóstico detectados en muestras clínicas. Esta estrategia es tractiva como herramienta diagnóstica, pues no se necesita espuesta inmune activa.
Fragilidad ósea en el síndrome de hiperinmunoglobulinemia E: SHIE
Authors: Rosahyra Sandoval , Pablo Patiño , Carlos Montoya , Olivares Margarita , Helì Salgado , José Franco
Published: January 2025

SHIE se caracteriza por expresión variable de anormalidades inmunológicas (eczema crónico, abscesos en piel, neumonías con neumatoceles, eosinofilia e IgE sérica elevada), y anormalidades no inmunes del tejido conectivo, dentición y sistema esquelético. (1) La incidencia de anormalidades esqueléticas (fracturas recurrentes) en una cohorte de 98 pacientes es de 43%. (2)
Correlación clínica y toxinológica en pacientes con envenenamiento escorpiónico en Colombia
Authors: Cárdenas Silvia , Otero Rafael , Quintana Juan , Díaz Cadavid Abel , Navío Elvira , Toro Fabiola , Paniagua Jorge , García Walter , Estévez Judith , Mancilla Rita , Alagón Alejandro
Published: January 2025

En Colombia se presentan accidentes graves y fatales por picaduras de escorpión (1), especialmente por las especies Tityus asthenes, T. pachyurus y Centruroides gracilis en los departamentos de Antioquia y Tolima con un 24% de casos moderados / graves (2). En el presente trabajo se estandarizará un inmunoensayo (ELISA) para determinar las concentraciones de veneno y antiveneno en pacientes con accidente escorpiónico en los departamentos de Antioquia y Tolima, durante las primeras 48 horas de tratamiento.
Características del gen Duffy y su relación con infección malárica en diferentes comunidades étnicas del Chocó
Authors: González L. , Gómez J. , Vega O. , Herrera S. , Bedoya Berrío Gabriel , Ramírez J. , Carmona Fonseca Jaime , Maestre A.
Published: January 2025

En humanos la resistencia innata a la infección por Plasmodiumtiene relación con la presencia de polimorfismos en genes o en proteínas expresadas en la superficie de los eritrocitos. La condición homocigótica negativa para el grupo sanguíneo Duffy resulta en resistencia a la infección por Plasmodium vivax. En Colombia se conoce muy poco acerca de la frecuencia de polimorfismos eritrocitarios que confieren resistencia parcial o completa contra la malaria por P. vivax, por lo cual se hace necesario realizar una caracterización más profunda de estos fenómenos (1,2)
Evaluación de cisticerco de taenia crassiceps como antígeno sustituto para el diagnóstico de la neurocisticercosis
Authors: Botero Luz Elena , Agudelo Sonia
Published: January 2025

Para el diagnóstico de la neurocisticercosis (NCC) se requiere de extractos antigénicos obtenidos de los cisticercos de Taenia solium (T.so), lo cual presenta dificultades técnicas por la difícil consecución de cerdos naturalmente infectados (1). Sin embargo, los extractos antigénicos obtenidos de Taenia crassiceps (T.cra) muestran una alta homología con los de T.so, brindando ventajas en la producción de antígenos para implementar en técnicas serológicas (2,3). Nuestro grupo ha venido trabajando en la búsqueda de alternativas para el diagnóstico serológico de cisticercosis humana y porcina enColombia y en el establecimiento de un modelo animal de fácil mantenimiento que permita la obtención de cisticercos a gran escala.
Evaluación de la concentración de fention en leche y actividad de colinesterasas eritrocíticas en bovinos en lactancia
Authors: Nicolás Ramírez , Ruiz Jhon , Zapata María , Betancur María , Carlos López
Published: January 2025

La leche es uno de los principales alimentos para el consumo humano, pero en el proceso de producción desde el origen (granja) puede estar sometida a múltiples tipos de contaminación. Una fuente de contaminación muy importante son los pesticidas, entre los cuales están los organofosforados, (OP), los que se utilizan, entre otros fines, para el control de ectoparásitos como la mosca en el ganado lechero, lo cual es una práctica común en nuestro medio. Subsiguiente al tratamiento de vacas lecheras con OP, estos productos pueden ser eliminados a través de la leche y residuos de OP ser encontrados en ella. Los pesticidas, entre ellos los OP como el fention, plantean un serio peligro para la salud, por lo tanto, son necesarios estudios que profundicen en el comportamiento de estos plaguicidas en los líquidos corporales de los animales especialmente en los de consumo humano como la leche, con el fin de conocer el riesgo real para la salud de los animales y del hombre. Aunque la medición de los residuos tóxicos y sus metabolitos se puede hacer en otros líquidos biológicos como la sangre y la orina, dadas las características especiales de consumo de leche por los humanos, es necesario cuantificar los residuos de plaguicidas en ella.
Modelo de datos para un sistema de información de urgencias
Authors: Flórez José
Published: January 2025

La toma de decisiones en los servicios de urgencias debe seruna acción documentada y personalizada de acuerdo a lacondición del paciente, existen protocolos y guías de manejoque son susceptibles de automatizarse. Para que un sistema detoma de decisiones clínicas basado en el computador funcionede una manera adecuada, se requiere una estrategia de capturaelectrónica de la información clínica de forma primaria. Cuandose pretende diseñar un sistema de información, sus interfacesdeben ser similares a lo que ocurre en la vida real; por esto esnecesario identificar y modelar como se maneja y cuales sonlos datos que se recolectan en la actualidad, en la historia clínicabasada en papel. Nuestro sistema de salud es único y particular y cuenta con un Sistema Integral de Información, el cual demandaunos datos mínimos de reporte.
Efecto del polimorfismo del receptor ? 2 adrenérgico sobre la respuesta antihipertensiva en pacientes con hipertensión esencial
Authors: Méndez Juan Carlos , Melguizo Isaac , García Edwin , McEwen Juan , Aristizabal Dagnovar
Published: January 2025

La hipertensión arterial esencial (HTE) es uno de los principales factores de riesgo cardiovascular y generador indirecto de la enfermedad coronaria, la mayor causa de muertes en Colombia y el mundo [1].El Sistema Nervioso Simpático (SNS) modifica la resistenciaarterial periférica a través del receptor ? 2 adrenérgico,  generando señales intracelulares que regulan la relajación delmúsculo liso vascular. Este receptor experimenta un procesodenominado desensibilización, es decir, cuando es activado porun agonista por tiempo prolongado, la respuesta no será de lamisma intensidad a la inicial. La desensibilización del receptor? 2 parece estar determinada por la estructura de aminoácidospolimórficos: Arginina 16 Glicina y Ácido glutámico 27 Glutaminaamino terminales. Estas variantes son codificadas por polimorfismos de un solo nucleótido (SNP) 46 y 79. La funciónde estos polimorfismos y su efecto en la función vascular escontroversial. Evidencias clínica e in vitro sugieren que la Glicina16 se desensibiliza mas rápido que la Arginina; igualmente, elÁcido glutámico 27 facilita la desensibilización versusglutamina[2].
Evaluación del efecto de tres polimorfismos en el gen del receptor adrenérgico beta-2 en el trabajo de parto pretérmino
Authors: Ríos Juan , García Cristina , Parra Sergio , Cuesta González Fanny
Published: January 2025

El trabajo de parto pretérmino (TPP), es una causa importantede morbilidad y mortalidad perinatal. Debido a la inmadurez y asu baja capacidad de adaptación al ambiente extrauterino, lasupervivencia neonatal y las complicaciones de un recién nacidopretérmino generan un problema de salud pública de importanciamundial.Los receptores adrenérgicos ? 2 (? 2AR) son el principal mecanismo de comunicación intercelular para inducir relajaciónde las fibras musculares miometriales y tanto estos receptores como sus vías de señalización intracelular sufren alteracionesimportantes en relación con el inicio del trabajo de parto normal.Recientemente se ha encontrado que la homocigozidad para el polimorfismo Arg16, que está asociado in vitro con la tenuación del proceso de disminución del número de los ? 2AR 1), protege del parto pretérmino (2), y que el alelo Glu27, sociado con resistencia a la desensibilización in vitro, contradictoriamente podría ser un factor de riesgo para el parto antes de las 37 semanas de gestación (3).
PCR-RFLP de secuencias ITS como método de identificación de especies de anopheles del subgénero nyssorhynchus
Authors: Zapata Mario , Trujillo Andrea , Agudelo Olga , Quiñones Martha , Tu Jake , Luckhart Shirley , Correa Margarita
Published: January 2025

La malaria constituye uno de los problemas más importantesde salud pública en Colombia. Los vectores son mosquitos delgénero Anopheles; en Colombia están presentes especies delsubgénero Nyssorhynchus, algunas de ellas importante vectoresde malaria, como: An. albimanus, An darlingi y An. nuñeztovari.Varias especies pertenecientes a este subgénero presentan altasimilaridad morfológica del adulto, generando dificultad en laidentificación taxonómica. En los últimos años se han utilizadomarcadores moleculares como los espaciadores internostranscritos (ITS) del DNA ribosomal (DNAr) para examinarvariaciones ínterespecies (ITS2) e intraespecie (ITS1) (1)
Clinical case of malignant endometrioid-associated neoplasia of a postoperative scar
Authors: Kayukova E. V.
Published: January 2025

Malignant endometrioid-associated neoplasias are malignant tumors wich develop as a result of malignant transformation of endometrioid heterotopias outside the uterus. The mechanisms of their transformation are diverse, and oncological risks are known only for ovarian and breast cancer.

The article presents a rare clinical case of malignant endometrioid-associated neoplasia of a postoperative scar in a 67-year-old woman. Differential criteria and prognostic factors of the disease course are considered. The literature data on this issue were analyzed. Literature search was carried out in PubMed, eLIBRARY.RU databases over the past 5 years was performed for the search words: malignant endometrioid-associated neoplasia, endometrioid cancer of postoperative scar.

Malignant endometrioid-associated neoplasia of the postoperative scar is a rare malignant tumor that develops from endometrioid heterotopia in women who have undergone surgery on the pelvic organs. Oncological look-out and timely routing of such patients to a specialized level can increase the effectiveness of treatment and improve the prognosis of such patients.
Netupitant/palonosetron (NEPA) for prophylaxis of nausea and vomiting induced by chemotherapeutic conditioning before autologous stem cell transplantation
Authors: Akhmedov M. I. , Lunin V. V. , Khairullina L. S. , Cherkashina I. V. , Chervontseva A. M. , Vernyuk M. A. , Semochkin S. V. , Fedenko A. A. , Kaprin A. D.
Published: January 2025

Background. Combination of 5-HT3-receptor inhibitors and NK1-inhibitors with dexamethasone and olanzapine is the standard-of-care measure for prevention of chemotherapy-induced nausea and vomiting in autologous hematopoietic stem cell transplant (auto-HCT) recipients.

Aim. To assess the efficacy and toxicity of netupitant/palonosetron (NEPA) as monotherapy in the prevention of nausea and vomiting induced by pretransplant conditioning.

Materials and methods. This prospective study included patients (n = 21) who underwent auto-HCT at the P.A. Herzen Moscow Oncology Research Institute – branch of the National Medical Research Radiological Centre. Patients with multiple myeloma were administered 1 capsule of NEPA 1 hour before conditioning, patients with lymphoma – 2 capsules: 1 hour before conditioning and 72 hours after the first dose of the drug. The primary endpoint was the complete response rate defined as no emesis and no rescue medication during the acute and delayed phases.

Results. Complete response in the overall cohort was achieved in 81 % of patients both in the acute and delayed phases. In the high-dose melphalan group and LEAM-conditioning group (lomustine, etoposide, cytarabine, melphalan), the rates were also identical in the acute and delayed phases and were 75 and 88.9 %, respectively. Complete control in the entire cohort was achieved in 66.7 % during acute phase and 76.2 % during delayed phase. Corresponding rates in high-dose melphalan group were 66.7 and 75 %, respectively, and in LEAM-conditioning group – 66.7 and 77.8 %, respectively.

Conclusion. NEPA monotherapy demonstrates high efficacy in auto-HCT recipients receiving highly-emetogenic pretransplant conditioning, while simplifying the antiemetic prophylaxis protocol as compared to four-drug-based regimens.
Review of the II Scientific and Practical conference “The role of modern laboratory diagnostics and an interdisciplinary approach in real clinical practice”. November 14, 2024, Moscow
Authors: Editorial Article
Published: January 2025

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First line chemotherapy in locally advanced and disseminated esophageal squamous cell carcinoma
Authors: Sokolovskiy V. V.
Published: January 2025

Retrospective analysis of the treatment results of 156 patients with locally advanced and disseminated esophageal squamous cell carcinoma was performed. The patient group included 124 (79.3 %) men (median age 64 years) and 32 (20.5 %) women (median age 63.4 years). Metastases were found primarily in the lymph nodes – 136 (87.2 %) cases, lungs – 44 (28.2 %) cases, liver – 38 (24.4 %) cases. The patients received treatment with a two-component drug combination: paclitaxel + carboplatin (ТР), or a four-component combination: docetaxel + cisplatin + leucovorin + 5-fluorouracil (mDCF). The mDCF combination showed higher rates of toxicity: hematogenic (neutropenia) and non-hematogenic (asthenia, weight loss, lower limb edema) complications. In 37 (23.7 %) patients, grade III and IV dysphagia were diagnosed. It was managed by endoscopic installation of self-expanding stents. Currently, despite toxic side symptoms, both schemes are safe and are the most commonly prescribed for locally advanced and disseminated esophageal squamous cell carcinoma.
Multiple myeloma and anti-BCMA CAR-T therapy: a literature review
Authors: Faenko A. P. , Dudina G. A. , Mabudzade C. K.
Published: January 2025

Significant progress has been made in the treatment of multiple myeloma (MM), leading to improved clinical outcomes. However, despite the success of traditional methods such as surgery, radiotherapy, and chemotherapy, the challenge of fully curing patients with relapsed and refractory MM remains pressing. A promising therapeutic approach is the use of chimeric antigen receptor T-cells (CAR-T), which has demonstrated efficacy in patients with resistant B-cell malignancies and is actively being studied for the treatment of MM. Special attention is being given to B-cell maturation antigen (BCMA) as a potential target for CAR-T therapy in MM.

The objective is to analyze the current state of anti-BCMA CAR-T therapy in ММ, covering aspects of production, preclinical and clinical trials, as well as examining therapy-related toxicity and relapses.

Data analysis was conducted using specialized medical databases such as PubMed, Scopus, Web of Science, Frontiers, and Google Scholar from 1974 to 2024. The article reviews latest achievements in CAR-T therapy for MM, current advances in the production and application of BCMA CAR T-cells, along with key challenges faced by this technology. The data obtained confirm significant progress in optimizing CAR T-cell structures and improving manufacturing processes, making the therapy more accessible for clinical use.

Although early-phase trials of anti-BCMA CAR-T therapy show promising results, challenges remain, such as toxicity and insufficient response in some patients. Optimization of CAR structure and manufacturing technologies may improve the efficacy and accessibility of CAR T-cell therapy, making it a key direction for future research.
«CRISIS», «REVOLUTION», «CIVIL WAR» AS COMPONENTS OF THE CONCEPT OF SCIENTIFIC REPRODUCTION OF THE SOCIAL PROGRESS OF UKRAINE IN 1917-1920
Authors:   Kuras Institute of Political and Ethnic Studies of the NAS of Ukraine Ukraine, Soldatenko Valerii
Published: January 2025

The article seeks to elucidate the logical interconnections, interdependencies, and reciprocal influences of significant social phenomena during one of the most pivotal periods in Ukrainian history. Even a general framework for understanding these phenomena can facilitate a constructive crystallization of approaches, enhance methodological consistency in research practices, and foster a clearer comprehension of events from a century ago, which are currently subjected to diverse, often conflicting or unconvincing interpretations within historiography and political science. By rationalizing the interplay and clarifying distinctions among the theoretical constructs of «crisis», «revolution», and «civil war» through the lens of the historical context from 1917–1920, this analysis presents opportunities for a more precise and realistic depiction of intricate social trends and processes. Specifically, this methodical examination reveals that a singular, linear model depicting progression along an ascending trajectory—moving «from the smaller to the larger»—is inadequate. Instead, it necessitates a more adaptable and dialectical approach; it becomes evident that not only can political crises precipitate revolutions—which may subsequently incite civil wars—but civil wars themselves can initiate a «reverse reversal», triggering political crises. Moreover, the ramifications of civil wars significantly alter the developmental trajectory of revolutions and influence choices regarding pathways for social development.
THE INFLUENCE OF INTERNATIONAL ORGANIZATIONS ON THE RESOLUTION OF THE GREEK-TURKISH POLITICAL CONFLICT
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Batrymenko Oleg , Nelipa Dmytro ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Tkach Oleg ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: January 2025

The article analyzes the influence of the European Union on the Greek-Turkish international political conflict. The set of scientific studies of Greek-Turkish relations is relevant in several dimensions: attention is focused on the nature of conflict communications, which provides a dimension of relations with the European Economic Community (EU) and the European Union (EU); turning points and periods of positive changes began in the Greco-Turkish conflict. The article is a theoretically grounded review of opinions and approaches about the causes, means, and consequences of EU participation in Greek-Turkish relations. It was determined that there is a lack of research devoted to the analysis of the impact of the EU on the ongoing Greek-Turkish conflict. The notions of Greek-Turkish relations about the role of the EU remain insufficiently theorized, remain analytical bases that consider all possible sources of EU influence, connect them with proitic, economic factors and conditions. It is proved that there is a gap filling. It was found out that, by specifying and alternatively applying the criteria of confusion about crucial turning points, the nature, scale of change can be corrected through defining the complex structure of your EU influence pathways.
Research on Strategies to Enhance Competitiveness of for Domestic Companies in Response to the Expansion of International E-commerce Platforms
Authors:   The Korean Logistics Research Association, Lee Kang-Hyun , Bang Sun-ho , Shin Kwang-Sup
Published: January 2025

This study employs an AHP (Analytic Hierarchy Process) analysis to identify key factors that enhance the competitiveness of domestic e-commerce platforms in response to the market expansion of global e-commerce companies. It evaluates the priority of these factors based on the perspectives of different stakeholders, including platform operators, sellers, and consumers.
A review of prior research on strategies for enhancing e-commerce platform competitiveness and government policies reveals that many key factors are repeatedly utilized. Based on these insights, interviews were conducted with experts—platform operators or sellers with over 10 years of experience—to identify variables deemed important by these professionals. The variables considered appropriate for inclusion in the survey questionnaire were selected from those highlighted by the experts. These variables were categorized into major factors and sub-factors, with the major factors being classified under political (P), economic (E), social (S), and technological (T) dimensions for further study. To derive the critical factors for improving the competitiveness of domestic platform companies, the survey targeted individuals employed in industries related to the e-commerce platform sector. The respondents included platform employees, sellers using e-commerce platforms, and consumers.
The results of this study indicate the following:
Platform Operators’ Perspective: Focus on ecosystem design and management to maximize profitability and attract both consumers and sellers.
Sellers’ Perspective: Emphasis on increasing sales, reducing costs, and maximizing profit.
In the e-commerce ecosystem, platform operators view sellers and consumers as customers, while sellers view consumers as customers.
Ultimately, the market entry of global e-commerce platforms poses challenges for domestic platform operators, sellers, and consumers. Stakeholders must cooperate to foster a fair and mutually beneficial ecosystem that can address these challenges and ensure sustainable growth. Only through collaboration among stakeholders, focusing on high-priority factors for each group, can domestic platforms counteract the ultra-low-priced goods strategies of global platforms and enhance their competitiveness.
Reducing the Parameter Dependency of Phase-Picking Neural Networks with Dice Loss
Authors: Park Yongsoo , Beroza Gregory C.
Published: January 2025

Training a neural network for picking seismic phase arrivals has been commonly posed as a segmentation problem. It is a highly imbalanced segmentation problem in the sense that the background vastly dominates the foreground because we are trying to pick the optimal single sample point that represents the arrival of a seismic phase in a many seconds long time window. Here, we test the Dice loss, which is a preferred loss function for highly imbalanced image segmentation problems. We show that phase-picking neural networks trained on the Dice loss behave in a binary fashion for which the prediction output is almost always either nearly 1 or nearly 0. This feature removes the strong dependence of data processing workflows on the prediction score threshold, which is an otherwise critical parameter to determine when using neural networks trained on the cross-entropy loss. When strategically used, models trained on the Dice loss can reduce the parameter dependency of machine learning-based seismic monitoring.
Earthquake Recurrence Estimates for Northern Caribbean Faults from Combinatorial Optimization
Authors: ten Brink Uri S. , Geist Eric L.
Published: January 2025

We use combinatorial optimization to find the optimal spatial distribution of random samples of earthquakes (≥6.5) that minimize the misfit in target slip rates for all faults in the northeast Caribbean, and we derive magnitude–frequency relationships with uncertainties for these faults. Slip rates for many faults are derived from geodetic block models, not direct measurements, because of their underwater locations. Predicted recurrence rates for earthquakes on the East Hispaniola and Puerto Rico trench faults are 220–450 yr for moment magnitude (M) 7 and 3000–5000 yr for M 8, with the maximum feasible magnitude of M 8.2. The most frequent earthquakes with magnitudes ≥7.0 are predicted on the large upper plate strike-slip faults, Enriquillo (EF), and Septentrional faults, commensurate with the historical record. Calais et al. (2023) suggested that shortening in western Hispaniola is accommodated on the offshore Jérémie and onshore Malpasse faults north and south of EF, instead of on terrestrial faults in the western Hispaniola and EF. Because of our system-modeling approach, such a configuration predicts less frequent earthquakes on EF and western Hispaniola and Muertos convergent zones. Recurrence times of a few hundred years for M 6.7 earthquakes are predicted on the submerged faults in Mona Passage, and infrequent M > 7 earthquakes are predicted on the Virgin Islands faults.
The Beautiful Risk of Education Is at Risk. Pedagogy as the Art of Providing Constructive Adversity
Authors: Winther Josefin
Published: January 2025

What is at stake when risk is eradicated from education? Education is a key arena for the development and growth of children and young people. Despite extensive knowledge about how a sound development and growth can take place, there are considerable developments in society that diminishes elements of risk in education. This article explores what is at stake when elements of risks are removed from education. In light of pedagogical and psychological theories, it demonstrates how different kinds of risks are essential for growth at different stages of development. The article aims to show the value of risk in education by highlighting just how intrinsic this element is to all aspects of growth and development.
Interpersonal Communication as a Basis for Cooperation Between Early School Education Teachers
Authors: Ławecka Emilia
Published: January 2025

The article presents the stages of the communication process between early childhood education teachers. The aim of the study is to show the impact of communication on teachers’ cooperation, including describing the formation of communication networks, which are communication structures. Another goal is to describe the features of communication that prove that it, like feedback, is one of the key factors of constructive cooperation. In this work, we will focus on analyzing the role and importance of dialogue between teachers, exploring its various aspects, from the impact on interpersonal relationships to the consequences for the quality of cooperation between teachers. The final goal is to indicate the advantages of interpersonal communication.
The Inclusion Process of Students with Special Educational Needs in Grades 1–3 and Its Impact on Psychological and Social Well-Being. Perspectives of Students, Teachers, and Parents
Authors: Klimowicz Joanna
Published: January 2025

This study aimed to examine the opinions of students, teachers, and parents regarding the inclusion process of children with special educational needs (SPE) in grades 1–3 of primary school. The research methodology was based on a diagnostic survey using questionnaires and interviews. The application of methodological triangulation contributed to obtaining a comprehensive view of the analyzed issue, which is crucial for drawing accurate conclusions and practical recommendations. This article presents an analysis of the obtained research results regarding the inclusion process, with a focus on the psychological well-being of students as described in the literature. The findings pertaining to the inclusion process in grades 1–3 of primary school enable a deeper understanding of the complex effects of this process and identification of areas requiring further support and improvement in educational practices. Due to the complexity of the issue, further research in this field is necessary.
Students’ Mental Well-Being and Its Determinants in Jesper Juul’s Pedagogy
Authors: Ozga Anna Urszula
Published: January 2025

Jesper Juul is a Danish educator, family therapist, creator of a humanistic approach to education, founder of the international organization Familylab which operates in over 15 countries around the world. The author equates the psychological well-being of an individual with mental health and developed psychosocial competencies, and in his numerous works he suggests teachers how to achieve such a goal. He believes that the following four areas should be developed in a young person: personal integrity (self-awareness, knowledge of one’s own needs, emotions, values and boundaries), self-esteem (i.e. what an individual knows about himself/herself and how he/she feels about it), self-confidence (which depends on the skills one has) and self-responsibility (in order for a person to be responsible for his/her own decisions, actions and choices). Juul repeatedly points to the crisis of the school and its destructive impact on the mental well-being of students, who in this institution are constantly assessed, required to be obedient, and cannot decide on the fulfillment of their basic needs. To improve the situation not only of students, but also of teachers and parents, he proposes: 1) to replace compulsory schooling with the right to education; 2) to modify the management culture at school and to develop a new type of leadership in education; 3) to take care of teachers, and, in particular, to equip them with competencies to build relationships; such content should also be introduced into the pedagogical preparation program for students – future teachers; 4) to thank students for going to school.
The Problem of Child Abuse and Neglect and the Selected Aspects of Social Capital
Authors: Czyżewska Monika
Published: January 2025

This review article, which analyzes empirical articles from the last 30 years, aims to point out the potential role of social capital in preventing child maltreatment at the micro and mesolevels: families and local communities. The analysis is based on foreign research (from English-language journals; unfortunately, there is not any research done by Polish researchers in this field) which examined whether and how social capital (including its aspects such as social trust, networks and social support) can reduce the risk of child abuse and neglect. The first part of the work contains an overview of basic terminological findings. Then, the literature on the subject was reviewed. The results of numerous studies indicate the important role of social capital in reducing the use of violent methods by parents, and the need to reach out to parents who suffer from depression or experience social isolation. The article ends with conclusions and proposals for actions at the local level aimed at supporting families and communities in preventing violence and neglect against children.
Education of a Child up to Seven Years Old in the Polish Care and Education System in the Opinions of Practitioners – Experts from Greater Poland
Authors: Sadowska Katarzyna Bożena
Published: January 2025

Since kindergartens and nurseries in Poland, despite the achievements of modern pedagogy, psychology and related sciences, still prefer the model of the directive, or even behavioral, education, the subject of the research presented in this study is the opinion of practitioners – experts regarding selected problems of educating a child up to seven years old in the Polish care system and education. The research aimed to identify the opinions of practitioners – experts regarding selected problems of education of children up to seven years of age in the Polish care and education system. The research problem is as follows: What are the selected problems of educating a child up to seven years old in the Polish care and education system? In connection with the above, many detailed problems were identified and described in the study. The research was carried out using the diagnostic survey method using the interview technique (with eight experts – practitioners with various seniority and professional experience from Greater Poland in the period from June to October 2023). The greatest shortcomings of educating a child up to the age of seven included the following: lack of child orientation, insufficiently qualified and reluctant staff towards children, lack of understanding of the determinants of educating a child up to the age of three, pursuit of directive education and education not adapted to the needs and capabilities of the child, and to the visual expectations parents and "expectations" related to documenting work, lack of "permission" for children’s play due to the instrumentalization of education and the commercialization of educational services.