bluuebunny/crossref_metadata_2025 huggingface dataset:
Haunts or helps from the past: Understanding the effect of recall on current self‐control
Authors: Nikolova Hristina , Lamberton Cait , Haws Kelly L.
Published: July 2015

Conventional wisdom suggests that remembering our past successes or failures can help us make better decisions in the present. But how successful is this practice in the domain of self‐control? Our work examines how the content of consumers' recollections (past self‐control successes versus failures) and the subjective difficulty with which this content comes to mind (easily or with difficulty) jointly shape consumers' self‐control decisions. When successes are easy to recall, people display more self‐control than when they have difficulty recalling successes. However, recalling failures prompts indulgence regardless of its difficulty. We suggest that these differences in behavior may exist because recalling failures has substantially different affective and cognitive consequences than does recalling successes. Consistent with this theory, we demonstrate that external cues toward high or low self‐certainty moderate the effects of recall on self‐control. Taken together, this work enhances our understanding of self‐control, self‐perceptions, and metacognition.
Reconsidering Contact Precautions for Endemic Methicillin-Resistant Staphylococcus aureus and Vancomycin-Resistant Enterococcus
Authors: Morgan Daniel J. , Murthy Rekha , Munoz-Price L. Silvia , Barnden Marsha , Camins Bernard C. , Johnston B. Lynn , Rubin Zachary , Sullivan Kaede V. , Shane Andi L. , Dellinger E. Patchen , Rupp Mark E. , Bearman Gonzalo
Published: July 2015

BACKGROUND

Whether contact precautions (CP) are required to control the endemic transmission of methicillin-resistant Staphylococcus aureus (MRSA) or vancomycin-resistant Enterococcus (VRE) in acute care hospitals is controversial in light of improvements in hand hygiene, MRSA decolonization, environmental cleaning and disinfection, fomite elimination, and chlorhexidine bathing.

OBJECTIVE

To provide a framework for decision making around use of CP for endemic MRSA and VRE based on a summary of evidence related to use of CP, including impact on patients and patient care processes, and current practices in use of CP for MRSA and VRE in US hospitals.

DESIGN

A literature review, a survey of Society for Healthcare Epidemiology of America Research Network members on use of CP, and a detailed examination of the experience of a convenience sample of hospitals not using CP for MRSA or VRE.

PARTICIPANTS

Hospital epidemiologists and infection prevention experts.

RESULTS

No high quality data support or reject use of CP for endemic MRSA or VRE. Our survey found more than 90% of responding hospitals currently use CP for MRSA and VRE, but approximately 60% are interested in using CP in a different manner. More than 30 US hospitals do not use CP for control of endemic MRSA or VRE.

CONCLUSIONS

Higher quality research on the benefits and harms of CP in the control of endemic MRSA and VRE is needed. Until more definitive data are available, the use of CP for endemic MRSA or VRE in acute care hospitals should be guided by local needs and resources.

Infect Control Hosp Epidemiol 2015;36(10):1163–1172
Topological effects on vorticity evolution in confined stratified fluids
Authors: Camassa R. , Falqui G. , Ortenzi G. , Pedroni M.
Published: July 2015

For a stratified incompressible Euler fluid under gravity confined by rigid boundaries, sources of vorticity are classified with the aim of isolating those which are sensitive to the topological configurations of density isopycnals, for both layered and continuous density variations. The simplest case of a two-layer fluid is studied first. This shows explicitly that topological sources of vorticity are present whenever the interface intersects horizontal boundaries. Accordingly, the topological separation of the fluid domain due to the interface–boundary intersections can contribute additional terms to the vorticity balance equation. This phenomenon is reminiscent of Klein’s ‘Kaffeelöffel’ thought-experiment for a homogeneous fluid (Klein, Z. Math. Phys., vol. 59, 1910, pp. 259–262), and it is essentially independent of the vorticity generation induced by the baroclinic term in the bulk of the fluid. In fact, the two-layer case is generalized to show that for the continuously stratified case topological vorticity sources are generically present whenever density varies along horizontal boundaries. The topological sources are expressed explicitly in terms of local contour integrals of the pressure along the intersection curves of isopycnals with domain boundaries, and their effects on vorticity evolution are encoded by an appropriate vector, termed here the ‘topological vorticity’.
Effect of NMDAR antagonists in the tetrabenazine test for antidepressants: comparison with the tail suspension test
Authors: Skolnick Phil , Kos Tomasz , Czekaj Janusz , Popik Piotr
Published: July 2015

Objective

The N-methyl-d-aspartate receptor (NMDAR) antagonist ketamine, produces rapid and enduring antidepressant effect in patients with treatment-resistant depression. Similar dramatic effects have not been observed in clinical trials with other NMDAR antagonists indicating ketamine may possess unique pharmacological properties. Tetrabenazine induces ptosis (a drooping of the eyelids), and the reversal of this effect, attributed to a sympathomimetic action, has been used to detect first-generation antidepressants, as well as ketamine. Because the actions of other NMDAR antagonists have not been reported in this measure, we examined whether reversal of tetrabenazine-induced ptosis was unique to ketamine, or a class effect of NMDAR antagonists.

Methods

The effects of ketamine and other NMDAR antagonists to reverse tetrabenazine-induced ptosis were examined and compared with their antidepressant-like effects in the tail suspension test (TST) in mice.

Results

All the NMDAR antagonists tested produced a partial reversal of tetrabenazine-induced ptosis and, as expected, reduced immobility in the TST. Ketamine, memantine, MK-801 and AZD6765 were all about half as potent in reversing tetrabenazine-induced ptosis compared to reducing immobility in the TST, while an NR2B antagonist (Ro 25-6981) and a glycine partial agonist (ACPC) were equipotent in both tests.

Conclusion

The ability to reverse tetrabenazine-induced ptosis is a class effect of NMDAR antagonists. These findings are consistent with the hypothesis that the inability of memantine, AZD6765 (lanicemine) and MK-0657 to reproduce the rapid and robust antidepressant effects of ketamine in the clinic result from insufficient dosing rather than a difference in mechanism of action among these NMDAR antagonists.
Glee's McKinley High: Following Middle America's sexual taboos
Authors: ADAMS JIMI
Published: July 2015

Writers for popular media frequently draw on insights known about social networks in developing their plotlines and character biographies (whether in books, television, movies, etc.). Perhaps most known to network analysts in this respect, Freeman (2000) presents a collection of network concepts represented in comic strips. These depictions often are consistent with the patterns network analysts observe in real-world empirical examples. For example, the long-running sitcom Friends exhibited strong homophily (McPherson et al., 2001) or assortative mixing on race and socioeconomic status among the main characters. Other times the violation of these typical patterns can serve to generate dramatic tension or a source of comedy. For example transitivity—or the tendency of one's friends to also become friends (Holland & Leinhardt, 1972)—is absent in the movie Hush where Jessica Lange's character plots to kill the daughter-in-law she does not like. P-O-X social balance (Heider, 1948) describes the tendency for friends to share common interests, which was violated to comedic effect in the Seinfeld episode where Jerry's character simply cannot accept his date's refusal to try a taste of the pie he finds delicious, bothering him for days and ultimately leading to his ending the relationship.
THE NEW FUNDAMENTAL NORM OF RECOVERY FOR LOSSES TO EXPRESS TRUSTS
Authors: Turner P.G.
Published: July 2015

THE principles for recovering monetary relief for losses to express trusts have recently been uncertain, especially in “commercial” situations. Where trustees undertook to hold money on trust for a lender and to advance the money to a borrower after receiving security documents, the trustees no doubt breach the trust by advancing the money without first receiving the security documents. However, since Target Holdings v Redferns [1996] A.C. 421, it has been uncertain what measure of relief the lender-beneficiary can recover – and especially whether the measure differs according to (1) whether the form of relief claimed is a general accounting or “equitable compensation” for only particular defaults or (2) whether the circumstances are “commercial”. Under the accounting doctrines as traditionally applied, trustees unable to vouch for trust assets they earlier received could not reduce their liability by showing that part or all of the loss would have been suffered even had they performed the trust correctly. The trustees were responsible for the misapplied sum regardless of causal enquiries. But, in Target, the House of Lords – emphasizing the commercial nature of the case – denied a lender-beneficiary's claim to recover the full sum wrongly disbursed by trustees. The significance of the case has been contested. Did Target change a fundamental norm of monetary relief for losses suffered through breach of trust – a norm applicable regardless of whether the form of relief claimed is a general accounting or equitable compensation for only particular defaults? Did Target instead leave the traditional accounting doctrines untouched, and create a new remedy of equitable compensation for breach of trust? Or did Target establish a “commercial” exception to traditional principles of trustee accountability, an exception limiting the quantum of relief? Indeed, was Target decided per incuriam?
THE AMENDED DIMINISHED RESPONSIBILITY PLEA
Authors: Rogers Jonathan
Published: July 2015

IN R. v Golds [2014] EWCA Crim 748, the Court of Appeal was asked to clarify the meaning of “substantially impaired” in the partial defence of diminished responsibility in murder cases. By virtue of s. 2(1) of the Homicide Act 1957, as amended by the Coroners and Justice Act 2009, s. 52, diminished responsibility is made out where:

(1)

… D was suffering from an abnormality of mental functioning which –

(a)

arose from a recognised medical condition,

(b)

substantially impaired D's ability to do one or more of the things mentioned in subsection (1A), and

(c)

provides an explanation for D's acts and omissions in doing or being a party to the killing.

(1A)

Those things are –

to understand the nature of D's conduct;

to form a rational judgment;

to exercise self-control. …

The facts in Golds were tragically redolent of many such cases. Golds suffered from schizophrenia, and was said to live in fear of “everything” and to hear voices criticising and tormenting him. His partner (Claire) had registered to become his carer. He stopped taking his medication and his condition got steadily worse. On the fateful day, according to other witnesses, there was a difficult meeting with Claire and her family, and Golds later assaulted Claire at their home. Claire told Golds to leave, and they argued further over a bank card. Golds himself did not remember what happened next, but he fetched a knife and said that he would kill Claire, which he did (22 separate knife wounds were found on her body). When the police arrived, he said that Claire “had Satan in her eyes”.
WHOLE-LIFE SENTENCES IN THE UK: VOLTE-FACE AT THE EUROPEAN COURT OF HUMAN RIGHTS?
Authors: Hart Naomi
Published: July 2015

THE ECtHR has for the second time in three years engaged with the British Government's handling of whole-life prison terms. In Hutchinson v United Kingdom (Application no. 57592/08), Judgment of 3 February 2015, not yet reported, the Fourth Section accepted the authoritativeness of an English court's decision on the meaning of English law relating to the Home Secretary's discretion to reduce a whole-life sentence. It also yielded to national judges on whether this sentence review mechanism complies with the proscription on inhuman and degrading treatment in Article 3 of the ECHR.
STATISTICAL MODEL FOR THE RELATIONSHIP BETWEEN MAIZE KERNEL ORIENTATION AND SEED LEAF AZIMUTH
Authors: KOLLER ADRIAN , TORRES GUILHERME , BUSER MICHAEL , TAYLOR RANDY , RAUN BILL , WECKLER PAUL
Published: July 2015

Hand-planted plots of across-row-oriented corn seeds (Zeamays L.) produce highly structured leaf canopies and have shown significant yield advantage over randomly planted plots in prior studies. For further investigation of the phenomenon by simulation, the objective of this study was to develop a probabilistic model for the correlation between seed orientation and initial plant orientation. In greenhouse trials, the azimuthal orientation of kernels of four different hybrids was recorded at planting. At collar setting of the seed leaf, the orientation of the seed leaf was determined and the angular data subjected to the analytical methods of circular statistics. The results indicate that the correlation between seed azimuth and seed leaf azimuth can be described by a von Mises distribution. The probabilistic seed to seed leaf azimuth model described herein may be implemented in simulation models to investigate the effect of canopy architecture, canopy closure and light interception efficiency of corn under conditions of seed oriented planting.
Stratigraphy and depositional environments of the Late Famennian (Late Devonian) of Southern Belgium and characterization of the Strud locality
Authors: DENAYER JULIEN , PRESTIANNI CYRILLE , GUERIAU PIERRE , OLIVE SÉBASTIEN , CLÉMENT GAËL
Published: July 2015

The Famennian (Upper Devonian,c. 372 to 359 Ma) strata of Belgium have recently received much attention after the discoveries of early tetrapod remains and outstandingly preserved continental arthropods. The Strud locality has yielded a diverse flora and fauna including seed-plants, tetrapods, various placoderm, actinopterygian, acanthodian and sarcopterygian fishes, crustaceans (anostracans, notostracans, conchostracans and decapods) and a putative complete insect. This fossil assemblage is one of the oldest continental – probably fresh-water – ecosystems with a considerable vertebrate and invertebrate diversity. The study of the palaeoenvironment of the Strud locality is crucial because it records one of the earliest and most important phases of tetrapod evolution that took place after their emergence but before their terrestrialization. It raises the question of environmental and ecological conditions for the Devonian aquatic ecosystem and the selection pressures occurring at the onset of tetrapod terrestrialization. The present study characterized the fluvial facies of the Upper Famennian sedimentary rocks of Strud and the surrounding areas. The exceptional preservation of arthropods and plants in the main fossiliferous layers is explained by rapid burial in the fine-grained sediment of the quiet and confined flood plain environment. Newly investigated fossiliferous sections in the Meuse–Samson area led to the description and correlation of key sections (Strud, Wierde and Jausse sections, complemented by the less continuous Haltinne, Huy and Coutisse sections). Moreover, the investigated sections allowed a review of the age of the fossiliferous horizon, which is now definitely considered to be Late Famennian in age.
EFFECT OF NATIVITY AND DURATION OF RESIDENCE ON CHRONIC HEALTH CONDITIONS AMONG ASIAN IMMIGRANTS IN AUSTRALIA: A LONGITUDINAL INVESTIGATION
Authors: Pasupuleti Samba Siva Rao , Jatrana Santosh , Richardson Ken
Published: July 2015

This study examined the effect of Asian nativity and duration of residence in Australia on the odds of reporting a chronic health condition (cancer, respiratory problems, cardiovascular disease (CVD) and diabetes mellitus). Data were from waves 3, 7 and 9 of the Household Income and Labour Dynamics in Australia (HILDA) longitudinal survey, and multi-level group-mean-centred logistic regression models were used for the analysis. After covariate adjustment, Asian immigrants were less likely to report cancer and respiratory problem compared with native-born Australians. While there was no significant difference in reporting CVD, they were more likely to report diabetes than native-born people. Asian immigrants maintained their health advantage with respect to cancer regardless of duration of residence. However, after 20 years of stay, Asian immigrants lost their earlier advantage and were not significantly different from native-born people in terms of reporting a respiratory problem. In contrast, Asian immigrants were not measurably different from native-born Australians in reporting diabetes if their length of stay in Australia was less than 20 years, but became disadvantaged after staying for 20 years or longer. There was no measurable difference in the odds of reporting CVD between Asian immigrants and native-born Australians for any duration of residence. On the whole this study found that health advantage, existence of healthy immigrant effect and subsequent erosion of it with increasing duration of residence among Asian immigrants depends upon the chronic health condition.
Different chronological patterns of appearance of blood derived milk components during mastitis indicate different mechanisms of transfer from blood into milk
Authors: Wellnitz Olga , Zbinden Christina , Lüttgenau Johannes , Bollwein Heinrich , Bruckmaier Rupert M
Published: July 2015

This study aimed to describe chronological patterns of changes of various candidate blood components in milk during the acute phase of a mammary immune response in detail. Eight dairy cows were challenged withEscherichia colilipopolysaccharide in one udder quarter. Milk from challenged and control quarters and blood samples were taken before, and 1 and 2 h after challenge and then every 15 min until 5 h after challenge. The SCC, serum albumin, immunoglobulin (Ig)G1, IgG2, lactate dehydrogenase (LDH), and L-lactate in milk and blood, and α-lactalbumin in blood were analysed. All selected parameters in milk increased in challenged quarters but did not increase in control quarters. Milk IgG1, IgG2, serum albumin, and LDH were already significantly increased at 2 h after challenge whereas a significant increase of SCC was detectable at 2·75 h and L-lactate was increased at 2·25 h after challenge. In blood L-lactate was increased at 3·75 h after challenge, however, other factors in blood did not change significantly within the 5 h of experiment. In conclusion, the increase of blood components in milk during inflammation follows two different patterns: There is a rapid increase for IgG1, IgG2, or LDH, before the increase of SCC, and their concentrations reach a plateau within 3 h. On the other hand, SCC and L-lactate show a slower but consistent increase not reaching a plateau within 5 h after LPS challenge. L-lactate increases to higher concentrations in milk than in blood. This clearly shows that the increase of blood components follows different patterns and is therefore a controlled and compound-specific process and not exclusively an unspecific type of leakage.
Representation as power and performative practice: Global civil society advocacy for working children
Authors: HOLZSCHEITER ANNA
Published: July 2015

This article analyses global civil society advocacy in the field of child labour through the lens of theories on political representation in global governance. The article is sympathetic to newer theories on political representation which, fundamentally, understand representation as a dialectic of performative practices between representatives and their real or imagined constituencies. However, the article argues that the contemporary literature on political representation turns a blind eye on two aspects that are central to understanding this dialectic of representation in the child labour case: first, representation as power and second, the contested nature of citizenship. The article thus proposes an approach to political representation that allows highlighting the power-dimension inherent to the interrelation between formal and performative aspects of representation, that is, between civil society actors’ power to represent and their power over representation. Using such an approach, the article presents empirical insights on CSO representation in global policymaking on child labour – a field in which conflicts over legitimate representation, citizenship, and grassroots participation continue to be exceptionally fierce.
Approach to the study of fast electron transport in cylindrically imploded targets
Authors: Del Sorbo D. , Arikawa Y. , Batani D. , Beg F. , Breil J. , Chen H. , Feugeas J.L. , Fujioka S. , Hulin S. , Koga M. , MacLean H. , Morace A. , Namimoto T. , Nazarov W. , Nicolai Ph. , Nishimura H. , Ozaki T. , Sakaki T. , Santos J.J. , Spindloe Ch. , Tanaka K.A. , Vaisseau X. , Veltcheva M. , Yabuchi T. , Zhang Z.
Published: July 2015

The transport of relativistic electron beam in compressed cylindrical targets was studied from a numerical and experimental point of view. In the experiment, cylindrical targets were imploded using the Gekko XII laser facility of the Institute of Laser Engineering. Then the fast electron beam was created by shooting the LFEX laser beam. The penetration of fast electrons was studied by observing Kα emission from tracer layers in the target.
Design, testing and evaluation of an end-effector for self-relocation
Authors: Han Feng , Sun Kui , Liu Yu , Liu Hong
Published: July 2015

Two identical end-effectors are indispensable for self-relocation of a space manipulator, which is an effective way of extending its servicing capability. The prototype design is intimately linked to the requirements. The significant features and functionality of the end-effector and its grapple fixture are described, including the key analysis efforts. The characteristics of the end-effector and their suitability for self-relocation and payload handling were confirmed by testing, which used two prototype end-effectors, a semi-physical simulation testbed system with two, six degrees of freedom (DOF) industrial robot arms, and an air-bearing testbed system with a seven DOF manipulator. The results demonstrate that the end-effector satisfies the requirements and it can work well in a simulated space environment. With the compliance motion of the manipulator, the end-effector can perform soft capture and the manipulator can securely self-relocate and handle the payload.
Regularity bounds for complexes and their homology
Authors: NGUYEN HOP D.
Published: July 2015

LetRbe a standard graded algebra over a fieldk. We prove an Auslander–Buchsbaum formula for the absolute Castelnuovo–Mumford regularity, extending important cases of previous works of Chardin and Römer. For a bounded complex of finitely generated gradedR-modulesL, we prove the equality regL= maxi ∈$_{\mathbb Z}${regHi(L) −i} given the condition depthHi(L)⩾ dim Hi+1(L) - 1 for alli< supL. As applications, we recover previous bounds on regularity of Tor due to Caviglia, Eisenbud–Huneke–Ulrich, among others. We also obtain strengthened results on regularity bounds for Ext and for the quotient by a linear form of a module.
Permutation classes and polyomino classes with excluded submatrices
Authors: BATTAGLINO DANIELA , BOUVEL MATHILDE , FROSINI ANDREA , RINALDI SIMONE
Published: July 2015

This article introduces an analogue of permutation classes in the context of polyominoes. For both permutation classes and polyomino classes, we present an original way of characterizing them by avoidance constraints (namely, with excluded submatrices) and we discuss how canonical such a description by submatrix-avoidance can be. We provide numerous examples of permutation and polyomino classes which may be defined and studied from the submatrix-avoidance point of view, and conclude with various directions for future research on this topic.
Fontan conversion with hepatic vein exclusion: a means for hepatic preservation in single ventricle heart disease
Authors: Kogon Brian , McConnell Michael , Book Wendy
Published: July 2015

Patients with single ventricle heart disease often undergo staged surgical palliation, ultimately resulting in Fontan anatomy and physiology. Long-term consequences include cirrhosis of the liver, protein-losing enteropathy, and premature death. Elevated central venous pressure and venous congestion transmitted to the abdominal viscera have been implicated in the aetiology of many of these complications. We present a novel operation directed at protecting the liver and intestines by excluding the splanchnic venous return from the Fontan pathway. Instead of exposure to elevated Fontan pressures, the liver and intestines will be exposed to lower common atrial pressures. We hope that this modification will minimise the abdominal complications of Fontan anatomy and physiology.
Modeling Evacuation of a Hospital without Electric Power
Authors: Vugrin Eric D. , Verzi Stephen J. , Finley Patrick D. , Turnquist Mark A. , Griffin Anne R. , Ricci Karen A. , Wyte-Lake Tamar
Published: July 2015

Hospital evacuations that occur during, or as a result of, infrastructure outages are complicated and demanding. Loss of infrastructure services can initiate a chain of events with corresponding management challenges. This report describes a modeling case study of the 2001 evacuation of the Memorial Hermann Hospital in Houston, Texas (USA). The study uses a model designed to track such cascading events following loss of infrastructure services and to identify the staff, resources, and operational adaptations required to sustain patient care and/or conduct an evacuation. The model is based on the assumption that a hospital’s primary mission is to provide necessary medical care to all of its patients, even when critical infrastructure services to the hospital and surrounding areas are disrupted. Model logic evaluates the hospital’s ability to provide an adequate level of care for all of its patients throughout a period of disruption. If hospital resources are insufficient to provide such care, the model recommends an evacuation. Model features also provide information to support evacuation and resource allocation decisions for optimizing care over the entire population of patients. This report documents the application of the model to a scenario designed to resemble the 2001 evacuation of the Memorial Hermann Hospital, demonstrating the model’s ability to recreate the timeline of an actual evacuation. The model is also applied to scenarios demonstrating how its output can inform evacuation planning activities and timing.

VugrinED, VerziSJ, FinleyPD, TurnquistMA, GriffinAR, RicciKA, Wyte-LakeT. Modeling evacuation of a hospital without electric power. Prehosp Disaster Med. 2015;30(3):1-9
Sufficient Catheter Length for Pneumothorax Needle Decompression: A Meta-Analysis
Authors: Clemency Brian M. , Tanski Christopher T. , Rosenberg Michael , May Paul R. , Consiglio Joseph D. , Lindstrom Heather A.
Published: July 2015

Introduction

Needle thoracostomy is the prehospital treatment for tension pneumothorax. Sufficient catheter length is necessary for procedural success. The authors of this study determined minimum catheter length needed for procedural success on a percentile basis.

Methods

A meta-analysis of existing studies was conducted. A Medline search was performed using the search terms: needle decompression, needle thoracentesis, chest decompression, pneumothorax decompression, needle thoracostomy, and tension pneumothorax. Studies were included if they published a sample size, mean chest wall thickness, and a standard deviation or confidence interval. A PubMed search was performed in a similar fashion. Sample size, mean chest wall thickness, and standard deviation were found or calculated for each study. Data were combined to create a pooled dataset. Normal distribution of data was assumed. Procedural success was defined as catheter length being equal to or greater than the chest wall thickness.

Results

The Medline and PubMed searches yielded 773 unique studies; all study abstracts were reviewed for possible inclusion. Eighteen papers were identified for full manuscript review. Thirteen studies met all inclusion criteria and were included in the analysis. Pooled sample statistics were: n=2,558; mean=4.19 cm; and SD=1.37 cm. Minimum catheter length needed for success at the 95th percentile for chest wall size was found to be 6.44 cm.

Discussion

A catheter of at least 6.44 cm in length would be required to ensure that 95% of the patients in this pooled sample would have penetration of the pleural space at the site of needle decompression, and therefore, a successful procedure. These findings represent Level III evidence.

ClemencyBM, TanskiCT, RosenbergM, MayPR, ConsiglioJD, LindstromHA. Sufficient catheter length for pneumothorax needle decompression: a meta-analysis. Prehosp Disaster Med. 2015;30(3):15
Judicial Politics in International Trade Relations: Introduction to the Special Issue
Authors: DE BIÈVRE DIRK , POLETTI ARLO
Published: July 2015

International institutions have acquired an almost obvious presence in international politics and the question of their design has received prominent attention in recent years. Apart from key organizational characteristics like size of their membership, policy scope, depth of cooperation, decision-making rules, and their degree of openness towards non-state actors, one of their most striking features is their differing degree of legalization or judicialization (Goldstein and Martin, 2000; Zangl, 2008). Some institutions possess strong enforcement mechanisms or rules, while others rely on voluntary cooperation by their members.
Does Enforcement Matter? Judicialization in PTAs and Trade Flows
Authors: HICKS RAYMOND , KIM SOO YEON
Published: July 2015

This paper focuses on the variability of judicialization across preferential trade agreements (PTAs) and their impact on trade flows. We develop a categorization of PTAs that contrasts enforcement mechanisms with the level of trade policy discretion allowed by a trade agreement and the degree of flexibility allowed for members. Utilizing an original dataset of PTAs signed by countries in Asia, which has emerged as one of the most active regions of PTA formation and which exhibits wide variability in levels of judicialization, we compare the effects of trade policy discretion, flexibility provisions, and enforcement mechanisms in PTAs on trade flows. We examine the empirical strength of our theoretical framework distinguishing between discretion, flexibility, and enforcement using confirmatory factor analysis. The empirical analysis then goes on to examine their respective effects on trade flows. The results show that agreements with strong commitments, that is, those that remove more trade policy discretion from a government, lead to a greater expansion of trade between signatories. Enforcement and flexibility mechanisms, however, have mixed effects.
Dealing with PTAs in the WTO: Falling through the Cracks between ‘Judicialization’ and ‘Legalization’
Authors: MAVROIDIS PETROS C.
Published: July 2015

Preferential trade agreements (PTAs) have to be consistent with the WTO. Their monitoring at the multilateral level has failed so far for various reasons. The question arises what to do? Completion of the contract (‘legalization’) has failed repeatedly, and, in light of vested interests and incentives, there is no reason to believe it can succeed now. Judicialization can be discarded as well, since the incentives to enforce the WTO contract in this respect are lacking. The good arguments thus lie in favour of building bridges between the WTO and PTAs, and the weaker arguments with an effort to enhance enforcement against PTAs through either judicialization or legalization of the monitoring process.
Cooperation in the Shadow of WTO Law: Why Litigate When You Can Negotiate
Authors: POLETTI ARLO , DE BIÈVRE DIRK , CHATAGNIER J. TYSON
Published: July 2015

In the current multilateral trade regime, members often negotiate under the shadow of WTO law. This article develops a formal explanation of the way in which the credible threat to resort to and the actual use of WTO litigation can influence multilateral trade negotiations. We contend that the ability to impose costs on a defendant by way of litigation increases the complainant's bargaining power, opening a bargaining window and ultimately increasing the chances for cooperation in multilateral trade negotiations. On the other hand, the complainant's preference for loss-mitigation over gains from retaliation and its expectations about the likelihood that the defendant will not comply with an adverse ruling can augment the defendant's bargaining leverage. Thus, contrary to conventional wisdom, increased enforcement does not necessarily make actors shy away from further cooperation, although the credibility of the defendant's non-compliant threats crucially affects the location of any potential negotiated agreement. Empirically, we show that the argument can account for how Brazil, a potential complainant, and the EU and the US, two potential defendants, approached and bargained agricultural negotiations in the Doha Round.
No functional sexual dimorphism in Minorcan horse assessed by geometric morphometric methods
Authors: Parés-Casanova Pere M. , Allés C.
Published: July 2015

The existence of sexual dimorphism in the Minorcan horse, an autochthonous breed from Minorca Island in the Balearic archipelago (NW Mediterranean Sea), is established in the official standard, with females being shorter and longer than males as well as having slenderer necks and a squarer croup. However, no study so far has explored the size and shape components of this dimorphism separately. The aim of this study was to analyse the morphology of this breed using geometric morphometric methods in order to find size and shape differences between sire lines. The analysis was based on landmarks digitized in lateral view from 38 registered adult Minorcan horses (20 males and 18 females) within an age range of 3–14 years (average 7 years) with different performance goals. The analyses did not reveal any significant differences between the “shape” and “size” of male and female animals, for the landmarks studied, so the sexes are functionally similar.
Is crossbreeding of cattle beneficial for mixed farming systems in Central Java?
Authors: Widi T.S.M. , Udo H.M.J. , Oldenbroek K. , Budisatria I.G.S. , Baliarti E. , van der Zijpp A.J.
Published: July 2015

From 1980s onwards, Indonesia's government has been implementing crossbreeding with European beef breeds through artificial insemination to improve the beef performance of local cattle, in response to the increasing demand for meat. Crossbreeding is promoted and implemented throughout the country, regardless of the various agro-ecological zones, each endowed with different feed resources in the smallholder farming systems. This study analyses the impact at farm level of crossbreeding in the different mixed farming conditions in Central Java. Quantitative and qualitative information was collected through participatory approaches involving famers (n= 252) in four study areas representing three agro-ecological zones: Wet lowlands (subdivided in two areas based on the history of breeding local cattle and crossbreeding), Wet uplands and Dry uplands. Phenotypic characteristics, reproductive performances, and carcass characteristics of Ongole and crossbred cattle were assessed, together with farmers’ reasons for keeping Ongole or crossbred breeding stock, the functions of cattle on the farms and the Gross Margins (GM) of the cattle component on Ongole and crossbred farms. Across different agro-ecological zones, crossbreeding is not changing the farming systems: herd sizes, farm types, experience in cattle keeping and functions of cattle were about the same for Ongole and crossbred farms. The agro-ecological zones differed in the cropping pattern and feed resources; however, they did not differ in amounts of dry matter and crude protein fed to individual animals. Crossbreeding is changing the individual characteristics of cattle and consequently the market prices of animals. In general, mature female crossbred cattle were approximately 25 percent heavier than mature female local cattle. Male crossbred progeny was 16 percent heavier their local counterparts, whereas female crossbred progeny was 24 percent heavier than female local cattle. In terms of reproduction performances, both local and crossbred cows performed well with calf crops ranging between 73 and 86 percent per year. Most farmers preferred crossbred over Ongole cattle. Simmental cross is the most preferred. GM for crossbred and Ongole farms were comparable within the different study areas; selling prices of crossbreds are higher, but feed costs too. Crossbreeding will continue. It is promoted by government policies and farmers are motivated to keep crossbred cattle as body weights and market prices are higher than for Ongole cattle; however, farmers said that they do not prefer upgrading to very high levels of Simmental. A viable Ongole population is needed to reduce the risk of upgrading to too high levels of Simmental.
Estimation of Divergence from Hardy–Weinberg Form
Authors: Stark Alan E.
Published: July 2015

The Hardy–Weinberg (HW) principle explains how random mating (RM) can produce and maintain a population in equilibrium, that is, with constant genotypic proportions. When proportions diverge from HW form, it is of interest to estimate the fixation indexF, which reflects the degree of divergence. Starting from a sample of genotypic counts, a mixed procedure gives first the orthodox estimate of gene frequencyqand then a Bayesian estimate ofF, based on a credible prior distribution ofF,which is described here.
Temporal Stability of Implicit Sequence Knowledge
Authors: Tamayo Ricardo , Frensch Peter A.
Published: July 2015

Abstract. Previous research has shown that explicit and implicit knowledge of artificial grammars may decay at different rates (e.g., Tamayo & Frensch, 2007 ; Tunney, 2003 ). We extend these findings to sequential regularities embedded in serial reaction time (SRT) tasks. We compared the forgetting patterns of implicit and explicit knowledge after a retention interval of 7 days without rehearsal. Explicit knowledge decayed after 7 days, whereas implicit knowledge was retained. These data were modeled according to the assumptions involved in the single-system model suggested by Shanks, Wilkinson, and Channon (2003) . The best fit for the model was obtained by modifying the parameters related to (a) the common knowledge-strength variable for implicit and explicit knowledge, and (b) reliability of the explicit test. We interpret these dissociations as a boundary condition for single-system models that assume constant random noise to explain dissociations in the forgetting patterns of implicit and explicit sequential knowledge.
Phylogenetic congruence and ecological coherence in terrestrial Thaumarchaeota
Authors: Oton Eduard Vico , Quince Christopher , Nicol Graeme W , Prosser James I , Gubry-Rangin Cécile
Published: July 2015

Thaumarchaeota form a ubiquitously distributed archaeal phylum, comprising both the ammonia-oxidising archaea (AOA) and other archaeal groups in which ammonia oxidation has not been demonstrated (including Group 1.1c and Group 1.3). The ecology of AOA in terrestrial environments has been extensively studied using either a functional gene, encoding ammonia monooxygenase subunit A (amoA) or 16S ribosomal RNA (rRNA) genes, which show phylogenetic coherence with respect to soil pH. To test phylogenetic congruence between these two markers and to determine ecological coherence in all Thaumarchaeota, we performed high-throughput sequencing of 16S rRNA and amoA genes in 46 UK soils presenting 29 available contextual soil characteristics. Adaptation to pH and organic matter content reflected strong ecological coherence at various levels of taxonomic resolution for Thaumarchaeota (AOA and non-AOA), whereas nitrogen, total mineralisable nitrogen and zinc concentration were also important factors associated with AOA thaumarchaeotal community distribution. Other significant associations with environmental factors were also detected for amoA and 16S rRNA genes, reflecting different diversity characteristics between these two markers. Nonetheless, there was significant statistical congruence between the markers at fine phylogenetic resolution, supporting the hypothesis of low horizontal gene transfer between Thaumarchaeota. Group 1.1c Thaumarchaeota were also widely distributed, with two clusters predominating, particularly in environments with higher moisture content and organic matter, whereas a similar ecological pattern was observed for Group 1.3 Thaumarchaeota. The ecological and phylogenetic congruence identified is fundamental to understand better the life strategies, evolutionary history and ecosystem function of the Thaumarchaeota.
Metagenomic study of red biofilms from Diamante Lake reveals ancient arsenic bioenergetics in haloarchaea
Authors: Rascovan Nicolás , Maldonado Javier , Vazquez Martín P , Eugenia Farías María
Published: July 2015

Arsenic metabolism is proposed to be an ancient mechanism in microbial life. Different bacteria and archaea use detoxification processes to grow under high arsenic concentration. Some of them are also able to use arsenic as a bioenergetic substrate in either anaerobic arsenate respiration or chemolithotrophic growth on arsenite. However, among the archaea, bioenergetic arsenic metabolism has only been found in the Crenarchaeota phylum. Here we report the discovery of haloarchaea (Euryarchaeota phylum) biofilms forming under the extreme environmental conditions such as high salinity, pH and arsenic concentration at 4589 m above sea level inside a volcano crater in Diamante Lake, Argentina. Metagenomic analyses revealed a surprisingly high abundance of genes used for arsenite oxidation (aioBA) and respiratory arsenate reduction (arrCBA) suggesting that these haloarchaea use arsenic compounds as bioenergetics substrates. We showed that several haloarchaea species, not only from this study, have all genes required for these bioenergetic processes. The phylogenetic analysis of aioA showed that haloarchaea sequences cluster in a novel and monophyletic group, suggesting that the origin of arsenic metabolism in haloarchaea is ancient. Our results also suggest that arsenite chemolithotrophy likely emerged within the archaeal lineage. Our results give a broad new perspective on the haloarchaea metabolism and shed light on the evolutionary history of arsenic bioenergetics.
Human Upf1 is a highly processive RNA helicase and translocase with RNP remodelling activities
Authors: Fiorini Francesca , Bagchi Debjani , Le Hir Hervé , Croquette Vincent
Published: July 2015

RNA helicases are implicated in most cellular RNA-dependent events. In eukaryotes however, only few have been functionally characterized. Upf1 is a RNA helicase essential for nonsense-mediated mRNA decay (NMD). Here, using magnetic tweezers and bulk assays, we observe that human Upf1 is able to translocate slowly over long single-stranded nucleic acids with a processivity >10 kb. Upf1 efficiently translocates through double-stranded structures and protein-bound sequences, demonstrating that Upf1 is an efficient ribonucleoprotein complex remodeler. Our observation of processive unwinding by an eukaryotic RNA helicase reveals that Upf1, once recruited onto NMD mRNA targets, can scan the entire transcript to irreversibly remodel the mRNP, facilitating its degradation by the NMD machinery.
Obesity-induced DNA hypermethylation of the adiponectin gene mediates insulin resistance
Authors: Kim A. Young , Park Yoon Jeong , Pan Xuebo , Shin Kyung Cheul , Kwak Soo-Heon , Bassas Abdulelah F. , Sallam Reem M. , Park Kyong Soo , Alfadda Assim A. , Xu Aimin , Kim Jae Bum
Published: July 2015

Adiponectin plays a key role in the regulation of the whole-body energy homeostasis by modulating glucose and lipid metabolism. Although obesity-induced reduction of adiponectin expression is primarily ascribed to a transcriptional regulation failure, the underlying mechanisms are largely undefined. Here we show that DNA hypermethylation of a particular region of the adiponectin promoter suppresses adiponectin expression through epigenetic control and, in turn, exacerbates metabolic diseases in obesity. Obesity-induced, pro-inflammatory cytokines promote DNMT1 expression and its enzymatic activity. Activated DNMT1 selectively methylates and stimulates compact chromatin structure in the adiponectin promoter, impeding adiponectin expression. Suppressing DNMT1 activity with a DNMT inhibitor resulted in the amelioration of obesity-induced glucose intolerance and insulin resistance in an adiponectin-dependent manner. These findings suggest a critical role of adiponectin gene epigenetic control by DNMT1 in governing energy homeostasis, implying that modulating DNMT1 activity represents a new strategy for the treatment of obesity-related diseases.
Asymmetric synthesis of N-allylic indoles via regio- and enantioselective allylation of aryl hydrazines
Authors: Xu Kun , Gilles Thomas , Breit Bernhard
Published: July 2015

The asymmetric synthesis of N-allylic indoles is important for natural product synthesis and pharmaceutical research. The regio- and enantioselective N-allylation of indoles is a true challenge due to the favourable C3-allylation. We develop here a new strategy to the asymmetric synthesis of N-allylic indoles via rhodium-catalysed N-selective coupling of aryl hydrazines with allenes followed by Fischer indolization. The exclusive N-selectivities and good to excellent enantioselectivities are achieved applying a rhodium(I)/DTBM-Segphos or rhodium(I)/DTBM-Binap catalyst. This method permits the practical synthesis of valuable chiral N-allylated indoles, and avoids the N- or C-selectivity issue.
Extensive volatile loss during formation and differentiation of the Moon
Authors: Kato Chizu , Moynier Frederic , Valdes Maria C. , Dhaliwal Jasmeet K. , Day James M.D.
Published: July 2015

Low estimated lunar volatile contents, compared with Earth, are a fundamental observation for Earth–Moon system formation and lunar evolution. Here we present zinc isotope and abundance data for lunar crustal rocks to constrain the abundance of volatiles during the final stages of lunar differentiation. We find that ferroan anorthosites are isotopically heterogeneous, with some samples exhibiting high δ66Zn, along with alkali and magnesian suite samples. Since the plutonic samples were formed in the lunar crust, they were not subjected to degassing into vacuum. Instead, their compositions are consistent with enrichment of the silicate portions of the Moon in the heavier Zn isotopes. Because of the difference in δ66Zn between bulk silicate Earth and lunar basalts and crustal rocks, the volatile loss likely occurred in two stages: during the proto-lunar disk stage, where a fraction of lunar volatiles accreted onto Earth, and from degassing of a differentiating lunar magma ocean, implying the possibility of isolated, volatile-rich regions in the Moon’s interior.