bluuebunny/crossref_metadata_2025 huggingface dataset:
Topical Biocomposites Based on Collagen, Hyaluronic Acid and Metronidazole as Periodontitis Treatment
Authors: Kaya Madalina Georgiana Albu , Simonca Alice Geanina , Rau Ileana , Coman Alina Elena , Marin Minodora Maria , Popa Lacramioara , Trusca Roxana , Dinu-Pirvu Cristina-Elena , Ghica Mihaela Violeta
Published: October 2024

Background: It is well known that periodontitis affects the gums and surrounding connective tissue. The chronic inflammatory response induced by bacteria in the gingival tissue leads to the loss of the collagen connection between the tooth and the bone and ultimately to bone loss. Methods: In this context, the aim of this research was the obtaining and characterization of a drug release supports in the form of sponges based on collagen, hyaluronic acid as a support and metronidazole as an antibiotic for the treatment of periodontitis. The sponges were characterized by FT-IR spectroscopy, water uptake, contact angle, SEM microscopy, in vitro metronidazole release analysis from sponges and data modeling. Results: The results showed that all the sponges had a porous structure with interconnected pores, the pore sizes being influenced by hyaluronic acid and metronidazole; the spongious structure became much more dense for samples with metronidazole content. All metronidazole-loaded sponges showed good surface wettability and an adequate swelling capacity for a suitable antimicrobial release at the periodontal pocket. The porous structures allow a controlled release, fast in the first hour, essential to control the initial microbial load at the periodontal level, which continues slowly in the following hours to ensure an effective treatment of periodontitis. Conclusions: Correlating all physical–chemical and bio-pharmaceutical results obtained, a promising solution for periodontitis treatment could be a met-ronidazole–collagen–hyaluronic system consisting of 1% collagen, 1.5% metronidazole and 0.8% hyaluronic acid, and in vitro and in vivo tests are recommended to continue studies.
Present Scenario and Future Landscape of Payloads for ADCs: Focus on DNA-Interacting Agents
Authors: Valsasina Barbara , Orsini Paolo , Terenghi Chiara , Ocana Alberto
Published: October 2024

ADCs have emerged as a promising class of therapeutics, combining the targeting specificity of monoclonal antibodies with the cytotoxic potency of small-molecule drugs. Although the majority of approved ADCs are still based on microtubule binder payloads, the recent success of topoisomerase I inhibitors has revitalized interest in the identification of novel agents overcoming present limitations in the field including narrow therapeutic window and chemoresistance. The success of DNA binders as payload for ADCs has been very limited, up to now, due, among other factors, to high hydrophobicity and planar chemical structures resulting in most cases in ADCs with a strong tendency to aggregate, poor plasma stability, and limited therapeutic index. Some of these molecules, however, continue to be of interest due to their favorable properties in terms of cytotoxic potency even in chemoresistant settings, bystander and immunogenic cell death effects, and known combinability with approved drugs. We critically evaluated several clinically tested ADCs containing DNA binders, focusing on payload physicochemical properties, cytotoxic potency, and obtained clinical results. Our analysis suggests that further exploration of certain chemical classes, specifically anthracyclines and duocarmycins, based on the optimization of physicochemical parameters, reduction of cytotoxic potency, and careful design of targeting molecules is warranted. This approach will possibly result in a novel generation of payloads overcoming the limitations of clinically validated ADCs.
Encapsulation of Phloroglucinol from Rosenvingea intricata Macroalgae with Zinc Oxide Nanoparticles against A549 Lung Cancer Cells
Authors: Muthu Sakthivel , Lakshmikanthan Mythileeswari , Edward-Sam Edwin , Subramanian Mutheeswaran , Govindan Lakshmanan , Patcha Afrina Begum Mithen , Krishnan Kathiravan , Duraisamy Nallusamy , Jeyaperumal Selvakumari , Aziz Al Thabiani
Published: October 2024

Background/Objectives: Phloroglucinol (PHL), a phenolic compound extracted from the brown alga Rosenvingea intricata, exhibits potent antioxidant and anticancer properties. This study aims to extract, purify, and characterize PHL, and further develop functionalized zinc oxide nanoparticles (ZnO NPs) loaded with PHL to enhance its therapeutic potential. Methods: PHL was extracted using acetone and purified through Sephadex LH-20 column chromatography, yielding a highly enriched fraction (F-3). The purified compound was characterized by FTIR, HPLC, NMR, and LC-MS. ZnO NPs were synthesized, PEGylated, and conjugated with PHL, forming ZnO-PEG-PHL NPs. Their characterization included DLS, zeta potential, XRD, SEM-EDAX, and encapsulation efficiency studies. Antioxidant assays (DPPH, FRAP, ABTS, RPA) were performed and in vitro cytotoxicity on A549 lung cancer cells were determined to evaluate the therapeutic efficacy of PHL. Results: The purified PHL fraction showed a high phenolic content (45.65 PHL mg/g), which was was confirmed by spectral analysis. The ZnO-PEG-PHL NPs increased in size from 32.36 nm to 46.68 nm, with their zeta potential shifting from −37.87 mV to −26.82 mV. The antioxidant activity was superior for the ZnO-PEG-PHL NPs in all assays, while the in vitro cytotoxicity tests showed an IC50 of 40 µg/mL compared to 60 µg/mL for the ZnO NPs and 70 µg/mL for PHL. Apoptotic studies revealed significant cell cycle arrest and apoptosis induction. Conclusions: The synthesized ZnO-PEG-PHL NPs demonstrated enhanced antioxidant and anticancer properties, making them promising candidates for cancer therapy and antioxidant applications.
Stiff-Soft Hybrid Biomimetic Nano-Emulsion for Targeted Liver Delivery and Treatment of Early Nonalcoholic Fatty Liver Disease
Authors: Li Juan , Yin Mingxing , Tian Maoxian , Fang Jianguo , Xu Hanlin
Published: October 2024

Background: Nonalcoholic fatty liver disease (NAFLD) poses a risk for numerous metabolic diseases. To date, the U.S. Food and Drug Administration has not yet approved any medications for the treatment of NAFLD, for which developing therapeutic drugs is urgent. Dihydromyricetin (DMY), the most abundant flavonoid in vine tea, has been shown to be hepatoprotective. Its application was limited by low bioavailability in vivo; Methods: In order to improve the bioavailability of DMY and achieve liver-targeted delivery, we designed a DMY-loaded stiff-soft hybrid biomimetic nano drug delivery system (DMY-hNE). The in vivo absorption, distribution, pharmacokinetic profiles, and anti-NAFLD efficacy of DMY-hNE were studied; Results: DMY-hNE was composed of a stiff core and soft shell, which led to enhanced uptake by gastrointestinal epithelial cells and increased penetration of the mucus barrier, thus improving the in vivo absorption, plasma DMY concentration, and liver distribution versus free DMY. In an early NAFLD mouse model, DMY-hNE effectively ameliorated fatty lesions accompanied with reduced lipid levels and liver tissue inflammation; Conclusions: These findings suggested that DMY-hNE is a promising platform for liver drug delivery and treatment of hepatopathy.
Leveraging Numerical Simulation Technology to Advance Drug Preparation: A Comprehensive Review of Application Scenarios and Cases
Authors: Gu Qifei , Wu Huichao , Sui Xue , Zhang Xiaodan , Liu Yongchao , Feng Wei , Zhou Rui , Du Shouying
Published: October 2024

Background/Objectives: Numerical simulation plays an important role in pharmaceutical preparation recently. Mechanistic models, as a type of numerical model, are widely used in the study of pharmaceutical preparations. Mechanistic models are based on a priori knowledge, i.e., laws of physics, chemistry, and biology. However, due to interdisciplinary reasons, pharmacy researchers have greater difficulties in using computer models. Methods: In this paper, we highlight the application scenarios and examples of mechanistic modelling in pharmacy research and provide a reference for drug researchers to get started. Results: By establishing a suitable model and inputting preparation parameters, researchers can analyze the drug preparation process. Therefore, mechanistic models are effective tools to optimize the preparation parameters and predict potential quality problems of the product. With product quality parameters as the ultimate goal, the experiment design is optimized by mechanistic models. This process emphasizes the concept of quality by design. Conclusions: The use of numerical simulation saves experimental cost and time, and speeds up the experimental process. In pharmacy experiments, part of the physical information and the change processes are difficult to obtain, such as the mechanical phenomena during tablet compression and the airflow details in the nasal cavity. Therefore, it is necessary to predict the information and guide the formulation with the help of mechanistic models.
Stable Polymer-Lipid Hybrid Nanoparticles Based on mcl-Polyhydroxyalkanoate and Cationic Liposomes for mRNA Delivery
Authors: Shishlyannikov Sergey M. , Zubkov Ilya N. , Vysochinskaya Vera V. , Gavrilova Nina V. , Dobrovolskaya Olga A. , Elpaeva Ekaterina A. , Maslov Mikhail A. , Vasin Andrey
Published: October 2024

Background/Objectives: The development of polymer–lipid hybrid nanoparticles (PLNs) is a promising area of research, as it can help increase the stability of cationic lipid carriers. Hybrid PLNs are core–shell nanoparticle structures that combine the advantages of both polymer nanoparticles and liposomes, especially in terms of their physical stability and biocompatibility. Natural polymers such as polyhydroxyalkanoate (PHA) can be used as a matrix for the PLNs’ preparation. Methods: In this study, we first obtained stable cationic hybrid PLNs using a cationic liposome (CL) composed of a polycationic lipid 2X3 (1,26-bis(cholest-5-en-3β-yloxycarbonylamino)-7,11,16,20-tetraazahexacosane tetrahydrochloride), helper lipid DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine), and the hydrophobic polymer mcl-PHA, which was produced by the soil bacterium Pseudomonas helmantisensis P1. Results: The new polymer-lipid carriers effectively encapsulated and delivered model mRNA-eGFP (enhanced green fluorescent protein mRNA) to BHK-21 cells. We then evaluated the role of mcl-PHA in increasing the stability of cationic PLNs in ionic solutions using dynamic light scattering data, electrophoretic mobility, and transmission electron microscopy techniques. Conclusions: The results showed that increasing the concentration of PBS (phosphate buffered saline) led to a decrease in the stability of the CLs. At high concentrations of PBS, the CLs aggregate. In contrast, the presence of isotonic PBS did not result in the aggregation of PLNs, and the particles remained stable for 120 h when stored at +4 °C. The obtained results show that PLNs hold promise for further in vivo studies on nucleic acid delivery.
On the Human in Human Dignity
Authors: Catt Isaac E.
Published: October 2024

Only the incurious and philosophically challenged doubt the significance of dignity as a central issue in human interactions. Human dignity is much debated in religion, law, moral philosophy, anthropology, psychiatry, bioethics, sociology, philosophical anthropology, psychology, communication studies, and elsewhere. It is subject to competing discourses of ontology, epistemology, axiology, and logic. It appears in intercultural and international discussions of rights, autonomy, race, ethnicity, economics, war, and peace. It is contrasted with guilt, shame, and humiliation, both ordinary and extreme. However, the dynamic roots of dignity are usually presupposed or ignored in favor of reductionist typologies and antinomies. Returning us to lived experience and with post-humanist animal studies and the medical model of psychiatry as exemplary cases of reductionism, I interpret H. Plessner’s semiotic phenomenology as a communicative philosophy of the humane in dignity.
High-Wavenumber Infrared Spectroscopy of Blood Plasma for Pre-Eclampsia Detection with Machine Learning
Authors: Reganin Monteiro Gabriela , Silva Sara Maria Santos Dias da , Rizzato Jaqueline Maria Brandão , Silva Simone de Lima , Cortelli Sheila Cavalca , Silva Rodrigo Augusto , Nogueira Marcelo Saito , Silva de Carvalho Luis Felipe das Chagas e
Published: October 2024

Early detection of pre-eclampsia is challenging due to the low sensitivity and specificity of current clinical methods and biomarkers. This study investigates the potential of high-wavenumber FTIR spectroscopy (region between 2800 and 3600 cm−1) as an innovative diagnostic approach capable of providing comprehensive biochemical insights with minimal sample preparation. Blood samples were collected from 33 pregnant women and their corresponding 33 newborns during induction or spontaneous labor. By analyzing the dried blood plasma samples, we identified biomarkers associated with FTIR vibrational modes, including 2853.6 cm−1 (CH2 stretching in lipids), 2873.0 cm−1 (CH3 stretching in lipids and proteins), and 3279.7 cm−1 (O–H stretching related to water and proteins). Machine learning classification revealed 76.3% ± 3.5% sensitivity and 56.1% ± 4.4% specificity in distinguishing between pre-eclamptic and non-pre-eclamptic pregnant women, along with 79.0% ± 3.5% sensitivity and 76.9% ± 6.2% specificity for newborns. The overall accuracy for classifying all pregnant women and newborns was 71.8% ± 2.5%. The results indicate that high-wavenumber FTIR spectroscopy can enhance classification performance when combined with other analytical methods. Our findings suggest that investigating hydrophilic sites may complement plasma analysis in clinical settings.
High-Sensitivity Refractive Index Sensing Based on an SNPNS Composite Structure
Authors: Wu Di , Zhou Jingwen , Yu Xiang , Sun Yue
Published: October 2024

In this paper, we design and demonstrate an all-fiber-sensitive refractive index (RI) sensor based on the Mach–Zehnder interferometer (MZI). It is constructed by splicing two no-core fibers (NCFs) and a photonic crystal fiber (PCF) between two single-mode fibers (SMFs) to obtain an SMF–NCF–PCF–NCF–SMF composite structure (SNPNS). A study of the effect of varying PCF lengths on the RI reveals that the shorter the length, the higher the sensitivity. The maximum RI sensitivity of 176.9 nm/RIU is attained within the RI range of 1.3365–1.3767 when the PCF length in the SNPNS structure is 3 cm. Meanwhile, the sensor exhibits a high stability in water, with an RSD of only 0.0019% for the interference trough over a duration of two hours. This proposed sensing structure offers the advantages of a large extinction ratio, small size, low temperature sensitivity, and simple fabrication, exhibiting a great potential in RI measurements.
Genome-Wide Characterization and Development of Simple Sequence Repeat Markers for Molecular Diversity Analyses in Yellowhorn (Xanthoceras sorbifolium Bunge)
Authors: Yang Xiaoming , Wang Yuan , Yang Yuewen , Shareng Tuya , Xing Yukun , Bai Gaowa , Xing Zhongyu , Ji Yuanyuan , Liu Liling , Cao Gongxiang
Published: October 2024

Yellowhorn (Xanthoceras sorbifolium Bunge) is a valuable ornamental, medicinal, and woody oilseed species that is indigenous to China. The breeding improvement of yellowhorn has been hindered by a lack of suitable markers and sufficient information regarding the molecular diversity of this species. In this study, we conducted a comprehensive analysis of the yellowhorn genome to characterize the simple sequence repeat (SSR) loci. A total of 4,007,201 SSRs were successfully identified. Among these markers, mono-nucleotide SSRs were most abundant in the genome, while the tri-nucleotide SSRs accounted for the highest proportion in coding sequences. The GO and KEGG function enrichment analysis revealed that most SSR loci in coding sequences were associated with potential biological functions. Additionally, we used 30 pairs of primers to amplify SSR markers to gain a better understanding of the genetic variation in yellowhorn germplasms. The average values of observed heterozygosity and polymorphism information content were 0.625 and 0.517, respectively. Population structure, phylogeny and principal component analyses identified two distinct subclusters. Furthermore, yellowhorn germplasms with the same geographical distribution tended to group together. Moreover, a total of 26 yellowhorn core collections, which accounted for approximately 14.94% of the total yellowhorn germplasms, effectively represented the genetic diversity of all original germplasms. Our findings not only unveiled the genetic diversity and population structure of yellowhorn germplasms but also investigated the yellowhorn core collection, which will serve as a strong basis for yellowhorn management and genetic improvement.
Polyacrylamide Regulated Phytohormone Balance and Starch Degradation to Promote Seed-Potato Sprouting and Emergence
Authors: Yin Meiqiang , Hu Dongmei , Yu Xiaohang , Wang Yijie , Song Sa , Wang Chongyue , Hu Qilin , Wen Yinyuan
Published: October 2024

Potatoes are typically seeded as tubers, and their slow sprouting significantly impacts production. Therefore, the effects of polyacrylamide (20 g·L−1, 30 g·L−1, and 40 g·L−1) as a seed potato dressing on sprouting, seedling growth, and biomass were investigated. The phytohormone content, respiratory intensity, and starch metabolism enzyme activity were analyzed to elucidate the physiological mechanisms involved. The sprouting rate significantly increased after 20 g·L−1 and 30 g·L−1 treatments by 40.63% and 15.63%, respectively. The sprouting energy was the highest (52.0%) at 20 g·L−1, 7.67 times higher than the control. The 20 g·L−1 and 30 g·L−1 treatments also promoted emergence and growth, with the emergence rate increasing by 18.18% and 27.27% and growth increasing by over 8.1% and 11.9%, respectively. These effects were related to changes in phytohormone content and accelerated starch conversion. After treatment, the auxin and cytokinin contents in the apical buds increased significantly at the germination initiation stage, and during the germination and vigorous growth phases, the auxin, cytokinin, and gibberellin contents increased. Polyacrylamide treatment activated α-amylase and promoted starch degradation, increasing soluble sugar content to provide nutrients and energy for sprouting. This study provides a promising approach for promoting potato tuber sprouting and seedling growth.
Synergistic Phytochemical and Pharmacological Actions of Hair RiseTM Microemulsion: A Novel Herbal Formulation for Androgenetic Alopecia and Hair Growth Stimulation
Authors: Muangsanguan Anurak , Ruksiriwanich Warintorn , Linsaenkart Pichchapa , Jantrawut Pensak , Rachtanapun Pornchai , Jantanasakulwong Kittisak , Sommano Sarana Rose , Sringarm Korawan , Arjin Chaiwat , Sainakham Mathukorn , Castagnini Juan M.
Published: October 2024

Androgenetic alopecia (AGA) is a genetic condition characterized by an excessive response to androgens, leading to hairline regression in men and hair thinning at the vertex in women, which can negatively impact self-esteem. Conventional synthetic treatments for AGA are often limited by their side effects. In contrast, Thai medicinal plants offer a promising alternative with fewer adverse effects. This study investigates the synergistic phytochemical and pharmacological effects of a novel Hair RiseTM microemulsion, formulated with bioactive extracts from rice bran (Oryza sativa), shallot bulb (Allium ascalonicum), licorice root (Glycyrrhiza glabra), and corn kernels (Zea mays), for the treatment of hair loss. The microemulsion, in concentrations of 50%, 75%, and 100% (v/v), significantly enhanced the proliferation of human hair follicle dermal papilla cells (HFDPCs) compared to minoxidil. Additionally, it upregulated critical hair growth signaling pathways, including Wnt/β-catenin (CTNNB1), Sonic Hedgehog (SHH, SMO, GLI1), and vascular endothelial growth factor (VEGF), surpassing standard controls such as minoxidil and purmorphamine. The microemulsion also demonstrated potent anti-inflammatory and antioxidant properties by reducing nitric oxide production and oxidative stress, factors that contribute to inflammation and follicular damage in AGA. Furthermore, Hair RiseTM inhibited 5α-reductase (types 1–3), a key enzyme involved in androgen metabolism, in both human prostate cancer cells (DU-145) and HFDPCs. These findings suggest that Hair RiseTM microemulsion presents a promising natural therapy for promoting hair growth and reducing hair loss via multiple synergistic mechanisms, offering a potent, plant-based alternative to synthetic treatments.
Toxicity of Nitrite to Juvenile Sunray Surf Clam (Mactra chinensis Philippi)
Authors: Dai Yuanyuan , Dong Yubo , Wu Huimin , Chen Zilong , Yang Feng , Jia Jia , Chen Zhongzhi
Published: October 2024

Nitrite is a common pollutant in marine environments and can cause mortality in crustaceans and bivalves. The purpose of the current study is to understand nitrate’s toxicity to juvenile clams due to its potential impact on aquaculture and marine ecosystems. Juvenile sunray surf clams (Mactra chinensis Philippi) (1.00 ± 0.10 cm shell length, 0.75 ± 0.04 cm shell height) were exposed to varying concentrations of nitrite for 96 h and 20 days, respectively. The LC50 for survival at 96 h was 37 mg/L NO2-N. Histological evaluations were made on juvenile clams exposed at 30 mg/L after 20 d of exposure. Epithelial cells and digestive diverticulum are the best sub-lethal effect indicators. Shell length and antioxidant enzyme activities were measured at the beginning of the experiment and then observed 10 and 20 days after exposure. A logarithmic relationship was obtained between the relative growth rate (based on the shell length) of juvenile M. chinensis and the nitrite concentration. Compared to the control, activity suppression of superoxide dismutase and catalase activity was detected from the concentration of 1 mg/L NO2-N. It is recommended that nitrite concentrations remain below 1 mg/L to prevent stress during the early developmental stages of clams.
Advances in Smart-Response Hydrogels for Skin Wound Repair
Authors: Fan Yinuo , Wang Han , Wang Chunxiao , Xing Yuanhao , Liu Shuying , Feng Linhan , Zhang Xinyu , Chen Jingdi
Published: October 2024

Hydrogels have emerged as promising candidates for biomedical applications, especially in the treatment of skin wounds, as a result of their unique structural properties, highly tunable physicochemical properties, and excellent biocompatibility. The integration of smart-response features into hydrogels allows for dynamic responses to different external or internal stimuli. Therefore, this paper reviews the design of different smart-responsive hydrogels for different microenvironments in the field of skin wound therapy. First, the unique microenvironments of three typical chronic difficult-to-heal wounds and the key mechanisms affecting wound healing therapeutic measures are outlined. Strategies for the construction of internal stimulus-responsive hydrogels (e.g., pH, ROS, enzymes, and glucose) and external stimulus-responsive hydrogels (e.g., temperature, light, electricity, and magnetic fields) are highlighted from the perspective of the wound microenvironment and the in vitro environment, and the constitutive relationships between material design, intelligent response, and wound healing are revealed. Finally, this paper discusses the severe challenges faced by smart-responsive hydrogels during skin wound repair and provides an outlook on the combination of smart-responsive hydrogels and artificial intelligence to give scientific direction for creating and using hydrogel dressings that respond to stimuli in the clinic.
Composite Fiber Wrapping Techniques for Enhanced Concrete Mechanics
Authors: Li Zhongxu , Hao Guojun , Du Haoran , Fu Tianjian , Liu Depei , Huang Yuxiang , Ji Yongcheng
Published: October 2024

This study systematically investigates the enhancement effects of different fiber-reinforced polymer (FRP) materials on the axial compressive performance of concrete. Through experimental evaluations of single-layer, double-layer, and composite FRP reinforcement techniques, the impact of various FRP materials and their combinations on concrete’s axial compressive strength and deformation characteristics was assessed. The results indicate that single-layer CFRP reinforcement significantly improves concrete axial compressive strength and stiffness, while double-layer CFRP further optimizes stress distribution and load-bearing capacity. Among the composite FRP reinforcements, the combination with CFRP as the outer layer demonstrated superior performance in enhancing the overall structural integrity. Additionally, numerical analyses of the mechanical behavior of the reinforced structures were conducted using ABAQUS 2023HF2 finite element software, which validated the experimental findings and elucidated the mechanisms by which FRP influences the internal stress field of concrete. This research provides theoretical support and empirical data for the optimized design and practical application of FRP reinforcement technologies in engineering.
Mechanical Behavior of Polymeric Materials: Recent Studies
Authors: Collar Emilia P. , García-Martínez Jesús-María
Published: October 2024

This Special Issue is devoted to one of the most exciting fields in polymer science and technology: the many factors that influence the properties of polymer-based materials [...]
Using the Herschel–Bulkley Consistency Index to Characterise Complex Biopolymer Systems—The Effect of Screening
Authors: Raja Anand , Wilfert Philipp K. , Picken Stephen J.
Published: October 2024

The use of the consistency index, as determined from fitting rheological data to the Herschel–Bulkley model, is described such that it may yield systematic trends that allow a very convenient description of the dissipative flow properties of linear and branched (bio)polymers in general, both in molecular and weakly associated supramolecular solutions. The effects of charge-mediated interactions by the systematic variation of the ionic strength and hydrogen bonding by a systematic variation in pH, using levels that are frequently encountered in systems used in practice, is investigated. These effects are then captured using the associated changes in the intrinsic viscosity to highlight the above-mentioned trends, while it also acts as an internal standard to describe the data in a concise form. The trends are successfully captured up to 100 times the polymer coil overlap and 100,000 times the solvent viscosity (or consistency index). These results therefore enable the rapid characterization of biopolymer systems of which the morphology remains unknown and may continue to remain unknown due to the wide-ranging monomer diversity and a lack of regularity in the structure, while the macromolecular coil size may be determined readily.
Investigation of Temperature at Al/Glass Fiber-Reinforced Polymer Interfaces When Drilling Composites of Different Stacking Arrangements
Authors: Salem Brahim , Mkaddem Ali , Habak Malek , Dobah Yousef , Elfarhani Makram , Jarraya Abdessalem
Published: October 2024

This attempt covers an investigation of cutting temperature at interfaces of Fiber Metal Laminates (FMLs) made of glass fiber-reinforced polymer (GFRP) stacked with an Al2020 alloy. GFRP/Al/GFRP and Al/GFRP/Al composite stacks are both investigated to highlight the effect of stacking arrangement on thermal behavior within the interfaces. In a first test series, temperature history is recorded within the metal/composite stack interfaces using preinstalled thermocouples. In a second test series, a wireless telemetry system connected to K-type thermocouples implanted adjacent to the cutting edge of the solid carbide drill is used to record temperature evolution at the tool tip. Focus is put on the effects of cutting speed and stacking arrangement on the thrust force, drilling temperature, and delamination. From findings, the temperature histories show high sensitivity to the cutting speed. When cutting Al/GFRP/Al, the peak temperature is found to be much higher than that recorded in GFRP/Al/GFRP and exceeds the glass transition point of the GFRP matrix under critical cutting speeds. However, thrust force obtained at constitutive phases exhibits close magnitude when the stacking arrangement varies, regardless of cutting speed. Damage analysis is also discussed through the delamination factor at different stages of FML thickness.
3D Printing of Wood Composites: State of the Art and Opportunities
Authors: Ramaux Johan , Ziegler-Devin Isabelle , Besserer Arnaud , Nouvel Cécile
Published: October 2024

With the production of wood waste constantly on the increase, questions relating to its recycling and reuse are becoming unavoidable. The reuse of wood and its derivatives can be achieved through the production of composite materials, using wood as a reinforcement or even as the main matrix of the material. Additive manufacturing (also known as 3D printing) is an emerging and very promising process, particularly with the use of bio-based and renewable materials such as wood or its industrial derivatives. The aim of this paper is to present an overview of additive manufacturing processes using wood as a raw material and including industrial solutions. After presenting wood and its waste products, all the additive manufacturing processes using wood or its industrial derivatives will be presented. Finally, for each 3D printing process, this review will consider the current state of research, the industrial solutions that may exist, as well as the main challenges and issues that still need to be overcome.
Evaluating the Effectiveness of Cellulose-Based Surfactants in Expandable Graphite Wood Coatings
Authors: Jurczyková Tereza , Kmeťová Elena , Kačík František , Lexa Martin , Dědič Daniel
Published: October 2024

This study deals with the design of modern environmentally friendly and non-toxic flame retardants based on expandable graphite 25 K + 180 (EG) modified by cellulose ethers (Lovose TS 20, Tylose MH 300, Klucel H) and nanocellulose (CNC) that are biocompatible with wood and, therefore, are a prerequisite for an effective surfactant for connecting EG to wood. The effectiveness of the formulations and surfactants was verified using a radiant heat source test. The cohesion of the coating to the wood surface and the cohesion of the expanded graphite layer were also assessed. The fire efficiency of the surfactants varied greatly. Still, in combination with EG, they were all able to provide sufficient protection—the total relative mass loss was, in all cases, in the range of 7.38–7.83% (for untreated wood it was 88.67 ± 1.33%), and the maximum relative burning rate decreased tenfold compared to untreated wood, i.e., to 0.04–0.05%·s−1. Good results were achieved using Klucel H + EG and CNC + EG formulations. Compared to Klucel H, CNC provides significantly better cohesion of the expanded layer, but its high price increases the cost of the fireproof coating.
Optimization of Cellulase Production from Agri-Industrial Residues by Aspergillus terreus NIH2624
Authors: Kadoguchi Elen Ayumi , Velasco Josman , Silva Silvio Silvério da , Ingle Avinash P. , Segato Fernando , Chandel Anuj Kumar
Published: October 2024

The objective of this study was to assess the cellulase production of four fungi: Aspergillus terreus NIH2624, Aspergillus clavatus NRRL1, Aspergillus versicolor CBS583.65 and Aspergillus phoenicis ATCC3157, under submerged cultivation conditions. When these fungi were cultured in shake flasks using Mandels and Weber’s minimal medium with 1% sugarcane bagasse as a carbon source and 1.8 g/L of rice bran extract as a nitrogen source, A. terreus showed maximum cellulase production (filter paper activity (FPase) 3.35 U/mL; carboxymethyl cellulase activity (CMCase) 1.69 U/mL). Consequently, A. terreus was selected for the optimization study for cellulase production. Among the different tested carbon sources, A. terreus showed higher CMCase activity when it was cultivated on delignified sugarcane bagasse (1.64 U/mL) and higher FPase activity on sugarcane straw (7.95 U/mL). Regarding the nitrogen sources, the maximum FPase activity was observed when using rice bran (FPase, 8.90 U/mL) and soybean meal (FPase, 9.63 U/mL). The optimized fermentation medium (minimal medium with delignified sugarcane bagasse and rice bran as carbon and nitrogen sources, respectively) resulted in an enzymatic cocktail mainly composed of xylanases, with a maximum activity of 1701.85 U/mL for beechwood xylan, 77.12 U/mL for endoglucanase and 21.02 U/mL for cellobiohydrolase. Additionally, the enzymatic cocktail showed efficient activities for β-glucosidase, β-xylanase, arabinofuranosidase and lytic polysaccharide monoxygenases (LPMOs). This cellulase enzyme solution has the potential to efficiently hydrolyze lignocellulosic biomass, producing second-generation sugars in biorefineries.
The Transformative Role of Nano-SiO2 in Polymer Electrolytes for Enhanced Energy Storage Solutions
Authors: Jayanthi S. , Vahini M. , Karthickprabhu S. , Anusuya A. , Karthik N. , Karuppasamy K. , Ramachandran Tholkappiyan , Nichelson A. , Mahendran M. , Sundaresan B. , Vikraman Dhanasekaran
Published: October 2024

In lithium–polymer batteries, the electrolyte is an essential component that plays a crucial role in ion transport and has a substantial impact on the battery’s overall performance, stability, and efficiency. This article presents a detailed study on developing nanostructured composite polymer electrolytes (NCPEs), prepared using the solvent casting technique. The materials selected for this investigation include poly(vinyl chloride) (PVC) as the host polymer, lithium bromide (LiBr) as the salt, and silica (SiO2) as the nanofiller. The addition of nano-SiO2 dramatically enhanced the ionic conductivity of the electrolytes, with the highest value of 6.2 × 10−5 Scm−1 observed for the sample containing 7.5 wt% nano-SiO2. This improvement is attributed to an increased amorphicity resulting from the interactions between the polymer, salt, and filler components. A structural analysis of the prepared NCPEs using X-ray diffraction revealed the presence of both crystalline and amorphous phases, further validating the enhanced ionic transport. Additionally, the thermal stability of the NCPEs was found to be excellent, withstanding temperatures up to 334 °C, thereby reinforcing their potential application in lithium–polymer batteries. This work explores the electrochemical performance of a fabricated lithium-ion-conducting primary electrochemical cell (Zn + ZnSO4·7H2O|PVC: LiBr: SiO2|PbO2 + V2O5), which demonstrated an open circuit voltage of 2.15 V. The discharge characteristics of the fabricated cell were thoroughly studied, showcasing the promising potential of these NCPEs. With the support of superior morphological and electrical properties, as-prepared electrolytes offer an effective pathway for future advancements in lithium–polymer battery technology, making them a highly viable candidate for enhanced energy storage solutions.
Three-Dimensional Morphological Study of MnTe-like Structures by Assessment of Tortuosity Tensor Using Computational Fluid Dynamics
Authors: Prenesti Giuseppe , Petrassi Edoardo Walter , Guzzo Caterina , Mannella Silvia , Stellato Francesco , Crisafulli Laura , Azzato Giulia , Katovic Andrea , Lauria Agostino , Caravella Alessio
Published: October 2024

This paper focuses on a morphological study of the MnTe-like structures, carried out by the evaluation of the tortuosity tensor and other related parameters using a computational fluid dynamics approach recently developed by our research group. The present work focuses on all possible crystals—existing or not developed yet—having the same structure as that of the manganese telluride. This analysis provides new information not present yet in the open literature. The motivation behind this study lies in the importance of this type of structure in physics and material science. In particular, the structures investigated are anisotropic and bi-disperse, with two independent geometrical parameters controlling the structure shape: the ratio of the particle diameters (r1) and the normalised inter-particle distance (r2). Exploiting this fact, several different structures of the same family are created, changing these two parameters independently, also allowing inter-penetration of particles to enlarge the study’s applicability. The results are primarily obtained in terms of the tortuosity tensor, needed to catch and quantify the anisotropy of the structures. Then, other morphological parameters, such as connectivity, principal diffusion directions, and anisotropy factors, are evaluated, obtaining in this way a novel morphological characterisation of the structure. It is found that high values of tortuosity are observed at lower and higher values of {r1, r2}, which means that there exists a minimum value between them. Additionally, the anisotropy factor is found to be higher at lower values of {r1, r2} and lower at higher ones. This is in accordance with the fact that, as the inter-particle distance and the ratio between particle diameters increase, the structure enlarges, which implies a lower influence of the particle distribution and, thus, a gradually more isotropic structure.
Closing the Loop between Plastic Waste Management and Energy Cogeneration: An Innovative Design for a Flexible Pyrolysis Small-Scale Unit
Authors: Koumpakis Dimitrios-Aristotelis , Michailidou Alexandra V. , Vlachokostas Christos , Mertzanakis Christos
Published: October 2024

This study proposes a simplified unit that can be employed in an industrial facility for the utilization of its own abundant plastic waste, primarily from discarded packaging, to achieve full or partial energy autonomy. By converting this waste into synthetic pyrolysis oil equivalent to 91,500 L, the industry can power a combined heat and power generation unit. The proposed unit was designed with a focus on maintaining high temperatures efficiently while minimizing oxygen exposure to protect the integrity of hydrocarbons until they transform into new compounds. Pyrolysis stands as a foundational procedure, paving the way for subsequent thermochemical transformations such as combustion and gasification. This study delves into the factors affecting pyrolysis and presents analytically the mathematical formulations and relevant calculations in order to effectively design and apply a real-life system. On this basis, fuels from plastic waste can be produced, suitable for utilization in typical equipment meant to produce heat, estimated for six months’ operation and 800 MWh of electricity. This study enhances the transition towards a more circular and resource-efficient economy with technologies that unlock the latent energy contained within the discarded matter. Additionally, it demonstrates the feasibility of a moderate investment in a co-generation system for industries utilizing 568 tonnes of plastic waste per year. The design and accurate calculations of this study highlight the theoretical potential of this technology, promoting environmental sustainability and resource conservation.
Pastoral Reflection on Depictions of Contemporary Religious Subcultures in Online Discussions: An Analysis of Stereotypes (A Case Study from Slovakia)
Authors: Tkácová Hedviga
Published: October 2024

In terms of ethnic and religious characteristics, the majority of the Slovak population identifies with Slovak nationality and Christianity. Recent quantitative and qualitative research on the value orientations of Slovaks has revealed negative stereotypical and dismissive attitudes towards “difference”, which is often perceived as “non-Slovak” or “not ours”. In this social, cultural, and religious context, the question arises as to what understanding and tolerance of religious expressions can be expected in the current, often conflict-ridden society and what pastoral challenges arise from this. The aim of the research was to identify whom participants in online discussions consider to be the most “different” from themselves, which specific attributes of other religious subcultures (i.e., those other than the majority Christian) the discussants consider the most “different”, and how they evaluate this “difference”. The research method used was critical discourse analysis (CDA), which focuses on identifying and addressing social issues by analysing how these problems are presented in language—in our case, in written online comments within selected online discussions. The research confirms that the attitude of participants in online discussions towards the differences of other religious groups in the context of Slovakia is often accompanied by suspicion and majority negativism. The research findings point to the need for in-depth research focusing on the meaning and practical possibilities of reducing the social distance of the majority population concerning religious and ethnic minorities.
Community-Based Disaster Insurance for Sustainable Economic Loss Risk Mitigation: A Systematic Literature Review
Authors: Purwandari Titi , Surya Hilda Azkiyah , Riaman  , Hidayat Yuyun , Sukono  , Saputra Moch Panji Agung
Published: October 2024

This systematic literature review (SLR) explores the role of community-based catastrophe insurance (CBCI) as a tool for sustainable economic loss risk mitigation. Utilizing bibliometric analysis and a literature review, this study aims to reveal the methods employed in CBCI schemes from a novel perspective, highlighting their effectiveness in mitigating catastrophe risks. The PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology was employed to systematically collect and analyze articles sourced from the Scopus, ScienceDirect, and Dimensions databases. The findings provide a comprehensive summary of the CBCI implementation, including various considerations such as risk-sharing mechanisms, premium determination, and policy frameworks. This research offers a fresh perspective on CBCI as a sustainable approach to catastrophe risk mitigation, contributing valuable insights to policymakers, practitioners, and researchers interested in community resilience and disaster risk management.
The Characteristics of Precipitation with and without Bright Band in Summer Tibetan Plateau and Central-Eastern China
Authors: Yang Liu , Sun Nan , Ma Ming , Cui Chunguang , Wang Bin , Wang Xiaofang , Fu Yunfei
Published: October 2024

The bright band (BB) is an important symbol of the ice–water transition zone in stratiform precipitation, and the presence or absence of BB will lead to different microphysical processes. In this paper, the characteristics of BB and precipitation characteristics with and without BB in summer at Tibetan Plateau (TP) as well as Central-eastern China (CEC) are analyzed by using Global Precipitation Measurement (GPM) and the fifth generation ECMWF atmospheric reanalysis of the global climates (ERA5) datasets. The results show the freezing level height and BB height in TP are 0.5 km higher than those in CEC. With the increase in rain rate, the BB height decreases in TP but increases in CEC. The BB width becomes wider with the increase in maximum radar reflectivity. Secondly, the maximum reflectivity factor and particle diameter of stratiform precipitation with BB appear at 5 km, while the maximum reflectivity factor of stratiform precipitation without BB and convective precipitation appear near the ground. The particle diameter first decreases and then increases from the cloud top to the ground. Thirdly, the land surface temperature of convective precipitation is about 2.5 °C higher than stratiform precipitation with BB, indicating higher land surface temperatures are more likely to trigger convection. Lastly, BB can lead to a decrease in brightness temperature and an increase in polarized difference at 89 GHZ and 166 GHZ in CEC, likely due to the increasing ice particles in stratiform precipitation with BB.
Synergistic Potential of Optical and Radar Remote Sensing for Snow Cover Monitoring
Authors: Hidalgo-Hidalgo Jose-David , Collados-Lara Antonio-Juan , Pulido-Velazquez David , Fassnacht Steven R. , Husillos C.
Published: October 2024

This research studies the characteristics of snow-covered area (SCA) from two vastly different sensors: optical (Moderate-Resolution Imaging Spectroradiometer, or MODIS, equipped on board the Terra satellite) and radar (Synthetic Aperture Radar (SAR) on-board Sentinel-1 satellites). The focus are the five mountain ranges of the Iberian Peninsula (Cantabrian System, Central System, Iberian Range, Pyrenees, and Sierra Nevada). The MODIS product was selected to identify SCA dynamics in these ranges using the Probability of Snow Cover Presence Index (PSCPI). In addition, we evaluate the potential advantage of the use of SAR remote sensing to complete optical SCA under cloudy conditions. For this purpose, we utilize the Copernicus High-Resolution Snow and Ice SAR Wet Snow (HRS&I SWS) product. The Pyrenees and the Sierra Nevada showed longer-lasting SCA duration and a higher PSCPI throughout the average year. Moreover, we demonstrate that the latitude gradient has a significant influence on the snowline elevation in the Iberian mountains (R2 ≥ 0.84). In the Iberian mountains, a general negative SCA trend is observed due to the recent climate change impacts, with a particularly pronounced decline in the winter months (December and January). Finally, in the Pyrenees, we found that wet snow detection has high potential for the spatial gap-filling of MODIS SCA in spring, contributing above 27% to the total SCA. Notably, the additional SCA provided in winter is also significant. Based on the results obtained in the Pyrenees, we can conclude that implementing techniques that combine SAR and optical satellite sensors for SCA detection may provide valuable additional SCA data for the other Iberian mountains, in which the radar product is not available.
Stronger Impact of Extreme Heat Event on Vegetation Temperature Sensitivity under Future Scenarios with High-Emission Intensity
Authors: Yang Han , Zhong Chaohui , Jin Tingyuan , Chen Jiahao , Zhang Zijia , Hu Zhongmin , Wu Kai
Published: October 2024

Vegetation temperature sensitivity is a key indicator to understand the response of vegetation to temperature changes and predict potential shifts in ecosystem functions. However, under the context of global warming, the impact of future extreme heat events on vegetation temperature sensitivity remains poorly understood. Such research is crucial for predicting the dynamic changes in terrestrial ecosystem structure and function. To address this issue, we utilized historical (1850–2014) and future (2015–2100) simulation data derived from CMIP6 models to explore the spatiotemporal dynamics of vegetation temperature sensitivity under different carbon emission scenarios. Moreover, we employed correlation analysis to assess the impact of extreme heat events on vegetation temperature sensitivity. The results indicate that vegetation temperature sensitivity exhibited a declining trend in the historical period but yielded an increasing trend under the SSP245 and SSP585 scenarios. The increasing trend under the SSP245 scenario was less pronounced than that under the SSP585 scenario. By contrast, vegetation temperature sensitivity exhibited an upward trend until 2080 and it began to decline after 2080 under the SSP126 scenario. For all the three future scenarios, the regions with high vegetation temperature sensitivity were predominantly located in high latitudes of the Northern Hemisphere, the Tibetan Plateau, and tropical forests. In addition, the impact of extreme heat events on vegetation temperature sensitivity was intensified with increasing carbon emission intensity, particularly in the boreal forests and Siberian permafrost. These findings provide important insights and offer a theoretical basis and guidance to identify climatically sensitive areas under global climate change.