bluuebunny/crossref_metadata_2025 huggingface dataset:
The Prediction of the Ion Fraction of the Peptide with Selected Charge in Mass Spectrometry with Positive Electrospray Ionization
Authors: Skvortsov V.S. , Alekseychuk N.N. , Miroshnichenko Yu.V. , Rybina A.V.
Published: December 2019

The possibility of prediction of selected ion fraction in the total peptide fraction obtained during mass spectrometry with positive ionization
by electrospray was investigated on the basis of the amino acid sequence. The data obtained in the MS / MS experiment [Ramus et al., 2015] using
the standardized UPS1 kit (48 highly purified human proteins) and deposited in ProteomeXchange (identifier PXD001819) were used as the initial
data set. For each of the identified peptides belonging to one of the proteins of the UPS kit, a list of detected ions of different charge was formed.
The sum of the peak intensities detected for the primary ion was used as a measure of quantity. Since the ratio of the peptide fractions of ions with
different charges does not depend on the concentration in the experimental sample, the total sample was assembled by combining the data obtained
for different dilutions of UPS1. A set of equations of prediction of the fraction of 1+, 2+, and 3+ ions has been constructed. This computational
analysis has shown applicability of the proposed for prediction of the ion fraction of the peptide with selected charge in mass spectrometry with
positive electrospray ionization.
Exosomes of malignant tumors: prospects of omiсs diagnostics
Authors: Shushkova N.A. , Novikova S.E. , Zgoda V.G.
Published: December 2019

The main problems in the diagnostics and treatment of malignant tumors are early detection of the disease, prediction of the course of the disease and response to therapy. The solution may be associated with identification of biomarkers secreted by tumor cells within extracellular vesicles, known as exosomes. The study of exosome proteins attracts special attention, because their molecular composition can have information about tumor identity, and also represent a set of signaling molecules that regulate the processes of tumor progression and growth. In addition, the analysis of exosomes secreted into the extracellular space corresponds to the promising concept of a liquid biopsy. In this review, we have summarized the current experience in the molecular study of exosomes in various types of malignant tumors, including colorectal cancer, lung cancer, ovaries, prostate and breast cancer, with special emphasis on omics methods and outlined the prospects for their use in diagnosis.
The time course of changes in the state of monoaminergic systems in the brain of mice under the acute hypoxia with hypercapnia
Authors: Karpova I.V. , Mikheev V.V. , Marysheva V.V. , Kuritcyna N.A. , Bychkov E.R. , Shabanov P.D.
Published: December 2019

In socially isolated male outbred albino mice, the changes of monoaminergic systems under acute hypoxia with hypercapnia were studied. In cerebral cortex, hippocampus and striatum of the right and left sides of the brain, the concentrations of norepinephrine, dopamine, serotonin and their metabolites – dihydroxyphenylacetic, homovanillic and 5-hydroxyindoleacetic acids were investigated using the HPLC method. In isolated mice, which were not subjected to hypoxia with hypercapnia, higher levels of dopamine and serotonin in the left cortex were found. There was no asymmetry in monoamines and their metabolites in other studied brain structures. 10 min after the onset of exposure, acute hypoxia with hypercapnia resulted in a right-sided increase in norepinephrine levels and a decrease in dopamine levels in the striatum and serotonin levels in the hippocampus. In the cerebral cortex, 10 min after of hypoxic exposure beginning, there was a left-sided decrease in the dopamine content, while the original asymmetry found in the cortex of intact animals disappeared. In isolated mice perished of hypoxia with hypercapnia, almost all parameters returned to the control level. The exception was the ratio of serotonin metabolite level to the neurotransmitter, which in the right cortex became lower than in control animals. In white outbred mice, the brain monoaminergic systems are suggested to be relatively resistant to the negative consequences of hypoxia and hypercapnia, and corresponding shifts resulting in the reflex brain response to changes in the gas composition of the respiratory air.
Impairment of production and posttranslational changes of placental nuclear and membrane proteins with complicated pregnancy
Authors: Pogorelova T.N. , Gunko V.O. , Nikashina A.A. , Mikhelson A.A. , Alliluev I.A. , Larichkin A.V.
Published: December 2019

The content of nuclear and membrane proteins of the placenta, as well as posttranslational modification of these proteins in physiological pregnancy and placental insufficiency (PI) were studied. Differential centrifugation, electrophoresis in polyacrylamide gel, spectrophotometric methods were used. It was found that with PN there is a decrease in the degree of production of the studied proteins of varying degrees relative to control parameters. For chromatin proteins, a more pronounced decrease in the content of non-histone proteins was found in comparison with histones. Among histone fractions, the maximum decrease was detected in the H2A fraction. The degree of change in the amount of membrane proteins depends on the detergent used. Changes in posttranslational protein modifications disorders are characterized by a decrease in the content of amine and amide (especially difficult to hydrolyze) groups and an increase in carbonyl derivatives of proteins. The revealed changes in the composition and structure of the nuclear and membrane proteins of the placenta, performing numerous regulatory functions, can be triggering links in the chain of molecular damage in the placenta at PI.
Correlation of maternal age with birth weight: need to reemphasize
Authors: Goel Suyash , Abichandani Roshni
Published: December 2019

Background: Women at both ends of the reproductive age spectrum have unique outcomes which needs to be considered. Adolescents are at increased risk for anaemia, preterm delivery, fetal growth restriction and preeclampsia. The maternal mortality rate is higher on extremes of the age. However, there is marked variability of the birth wt even with in the age group from 19-35 years of age. The present study was conducted with an objective to assess the correlation of Maternal age with birth weight.Methods: A total of 135 women between age 19-35 years were considered who had delivered at term (n=135) and women with any risk factors were excluded. Women were divided in three groups with age <25 years, 26-30 years and >30 years. Both primigravida and multigravida women were included without considering the mode of delivery.Results: According to birth weight, 113 cases had their birth weight >2.5 kg and out of them 43, 56 and 14 cases belonged to age group <25, 26-30 and >30 years respectively while only 22 cases had their birth weight <2.5 kg and out of them 9, 8 and 5 cases had their age group <25, 26-30 and >30 years. Mean birth weight in age group <25 years was 2.96±0.46 kg, in age group 26-30 years, it was 3.19±0.47 kg and in age group >30 years it was 2.79±0.54. On applying ANOVA test, the difference was found statistically significant (p<0.01).Conclusions: The variation in birth weight with respect to maternal age is significant. Limitation of this study was group comprising of 135 women.
Evaluation of selected trace elements in the Moroccan type 2 diabetic patients
Authors: Omri Naoual El , Mekouar Fadwa , Assoufi Naoufal , Maaroufi Abdelkhalek , Smaali Jihane , Charef Amal , Jira Mohammed , Fatihi Jamal , Eljaoudi Rachid
Published: December 2019

Background: Several trace elements have been implicated in the etiology of type 2 diabetes, they can influence the onset or pathogenesis of diabetes in various ways including disruption of normal metabolism of glucose and insulin. The purpose of this work is to evaluate the serum status of copper, zinc, selenium, chromium and manganese in Moroccan type 2 diabetics compared to control group.Methods: Blood samples from 100 type 2 diabetics and 90 control subjects were analyzed for blood glucose, glycated hemoglobin (only for diabetics), lipid status and serum trace elements concentrations.Results: Glucose and triglyceride values were statistically higher in diabetics; while those of HDL-cholesterol were lower. Concentrations of zinc, selenium, chromium, and manganese were lower in diabetics compared to controls. In contrast, copper concentrations were higher.Conclusions: The status of trace elements is impaired in type 2 diabetics compared to a control group.
Study of diagnostic importance of fine needle aspiration cytology in various body lesions in a predominantly rural mountainous region of Jammu and Kashmir, G.M.C Doda, India
Authors: Sheikh Nazia T. , Khurshid Sumat Ul
Published: December 2019

Background: Fine Needle Aspiration Cytology (FNAC) is a procedure of choice as the first line of investigation in diagnosing non-neoplastic and neoplastic swellings of different areas as it has been found to be highly accurate and very useful, cost effective, offer early diagnosis after presentation and  treatment. In this present study in Department of pathology, data was collected and scrutinized. Cytology of various sites including breast, head and neck, salivary glands, thyroid, lymph nodes, etc. was done.Methods: FNAC is performed with the help of 21-22-gauge needle attached with 20 ml syringe by taking all aseptic precautions. Total of 70 cases were collected over a period of 4 months from April 2019 to July 2019.Results: Out of total 70 samples maximum number of cases were found in 21-30 years of age (16 cases); Males were 34(49%) and females were 36(51%) in number. 38 cases (54%) were non-neoplastic ,23 cases (33%) were neoplastic and in 9 cases (13%) no opinion was made. This study included 70 cytologically diagnosed cases. Out of which 38 cases (54%) were non-neoplastic, 23 cases (33%) neoplastic and in 9 cases (13%) no possible opinion could be made due to a number of factors like: Material not corresponding of representative area, small size of lesion, wrong technique, cystic areas, hemorrhage and necrosis and small foci of neoplastic lesion.Conclusions: Even though a number of limitations, FNAC has high accuracy in diagnosing benign and malignant lesions of various sites and thus reduces the period between presentation of tumours and their diagnosis which results in early management.
Seroprevalence of Hepatitis B virus surface antigen among pregnant females attending antenatal clinic at a tertiary care hospital in North India
Authors: Jahan Noor , Kumar Anil , Nigar Asma , Ahmad Siraj , Khatoon Razia , Chaudhary Nitin
Published: December 2019

Background: Hepatitis B infection is one of the most common public health problems worldwide. Hepatitis B virus Surface Antigen (HBsAg) positive mothers may transmit the virus vertically to neonates transplacentally during pregnancy, perinatally during delivery or postnatally through breast milk. Such neonates being carriers of virus are at a very high risk of developing chronic liver diseases at a younger age and also, they act as reservoirs of infection in the community. Objective of the study is to evaluate the seroprevalence of HBsAg in pregnant females attending Antenatal Clinic.Methods: A hospital based cross-sectional study was done from January to June 2019. A total of 840 pregnant females were included in the study who attended Antenatal Clinic for routine checkup whose blood samples were sent to Microbiology Laboratory for screening of HBsAg by Enzyme Linked Immunosorbent Assay (ELISA).Results: Out of 840 pregnant females included in the study, 8 were reactive to HBsAg, hence, prevalence was found to be 0.95%. The seroprevalence of HBsAg was found to be more (1.40%) in 26-35 year females. Maximum seropositivity was seen in females from urban areas (1.0%), those attending OPD of ANC (1.03%) and those who belonged to lower socio-economic class (1.02%).Conclusions: Routine free screening for HBV infection should be offered to all antenatal females to reduce the risk of vertical transmission to the neonates born to infected mothers, thereby, preventing them from becoming carriers and developing chronic hepatitis and hepatocellular carcinoma later in life.
Seroreactivity of HIV among patients attending a tertiary care hospital in North India: a retrospective analysis
Authors: Singh Akanksha , Chopra Deepak , Jahan Sarver , Khatoon Razia
Published: December 2019

Background: HIV (Human Immunodeficiency Virus) is the causative agent of AIDS (Acquired Immunodeficiency Syndrome). It belongs to the lentivirus subgroup of the family Retroviridae. The HIV/AIDS is spreading worldwide at an alarming rate. India has the third largest number of estimated people living with HIV/AIDS. Most common mode of HIV transmission is through heterosexual contact, blood transfusion, percutaneous, mucosal and perinatal mode. The present study was done to evaluate the seroreactivity of HIV among patients attending Integrated Counselling and Testing Centre (ICTC) of our Tertiary care hospital.  Methods: This retrospective study was conducted on data of patients who had attended ICTC and undergone HIV testing from January 2017 to January 2019. A total of 4519 patients were included in the study who gave their consent followed by pre-test and post-test counseling and were screened for HIV antibody by using rapid kit Comb-Aids.Results: Out of 4519 samples tested, 23 were reactive to HIV screening test, hence sero-reactivity of HIV was found to be 0.50%. Higher seroreactivity was seen among males (56.5%, 13/23), and patients aged 31-40 years (39.1%, 9/23). Maximum seroreactivity was found among patients of rural areas (73.9%, 17/23), indoor patients (91.3%, 21/23) and married patients (73.9%, 17/23).Conclusions: In this study the seroreactivity of HIV was found to be low among patients attending ICTC but still HIV continues to be a major contributor to the global burden of disease. ICTC data can be used as an important tool for planning and improving the national HIV/AIDS intervention strategy.
Effect of chemotherapy on serum nitric oxide levels in advanced stage breast cancer patients
Authors: Kadam Charushila Y. , Abhang Subodhini A.
Published: December 2019

Background: The role of nitric oxide is still unclear in advanced breast cancer patients undergoing adjuvant chemotherapy. This study was undertaken to investigate the effect of chemotherapy on serum nitric oxide levels in advanced stage breast cancer patients.Methods: In this observational study, clinically and histopathologically proven sixty female patients with advanced stage breast cancer were included. According to Tumor-Node-Metastasis (TNM) classification, patients were further grouped as stage III and stage IV. Thirty healthy and age-matched female controls were selected for comparison. Blood was collected from healthy controls and from breast cancer patients after surgery prior to chemotherapy and after three weeks of administration of first adjuvant chemotherapy cycle. Serum nitric oxide levels were measured by spectrophotometric method.Results: Significantly higher concentrations of serum nitric oxide were observed in breast cancer patients before chemotherapy in stage III (p<0.0001) and stage IV (p<0.0001) of the disease as compare to concentrations in healthy controls. The serum levels of nitric oxide were significantly decreased in stage III as well as stage IV of breast cancer patients after three weeks of receiving first adjuvant chemotherapy cycle as compare to levels before chemotherapy (p<0.0001), however serum nitric oxide levels were higher in stage III (p=0.0036) and stage IV (p<0.0001) of the disease as compare to healthy controls.Conclusions: Chemotherapy drug administration causes decrease in serum nitric oxide levels in advanced stages of breast cancer patients. Monitoring serum nitric oxide levels could be used to predict patients’ response to chemotherapy treatment in breast cancer.
Modeling and validation of L-asparaginase enzyme, an anticancer agent using the tools of computational biology
Authors: P. Praveen Reddy
Published: December 2019

Background: The L-Asparaginase is a medically important drug. The L-Asparaginase enzyme, an anticancer agent produced by microorganisms is used for the treatment of patients suffering from lymphoma and leukemia. The L-Asparaginase is economical and its administration is easy when compared to other commercial drugs available in market. Many microbes have been reported to produce the L-Asparaginase.Methods: In the present work the sequence of L-Asparaginase enzyme protein was obtained from the Universal Protein Resource (UNIPROT) server. The sequence of L-Asparaginase was used to generate 3-D model of L-Asparaginase in SWISS MODEL server. The constructed L-Asparaginase model was verified using Ramachandran Plot in PROCHECK server.Results: The FASTA format of L-Asparaginase enzyme of Bacillus subtilis strain 168 was retrieved from UNIPROT server. The FASTA format of L-Asparaginase was submitted to SWISS MODEL and its three-dimensional structural model was developed based on relevant template model. The model structure of L-Asparaginase was validated in PROCHECK server using Ramachandran Plot. The Ramachandran Plot of L-Asparaginase model inferred the reliability of L-Asparaginase structure model developed in SWISS MODEL server.  Conclusions: In the present study computational tools were exploited to develop and validate a potent anticancer drug, L-Asparaginase. Further the modeled L-Asparaginase enzyme protein can be improved using advanced bioinformatics tools and the same improved enzyme can be produced by improving the L-Asparaginase producing microbial strains by site-directed mutagenesis in the corresponding gene.
Reliability of diabetic neuropathy symptom and diabetic neuropathy examination scoring system for the diagnosis of diabetic peripheral neuropathy in type 2 diabetes mellitus patients
Authors: Ghosh Labani M. , Mannari Jyoti G.
Published: December 2019

Background: This study aims to evaluate the reliability of the Diabetic Neuropathy Examination Score (DNE), 10-g Semmes-Weinstein Monofilament Examination and Quantitative Sensory Testing by Vibration Perception Threshold (VPT) in the diagnosis of diabetic polyneuropathy and seek a cost effective and reliable screening method in diabetic OPD and IPD against the gold standard of NCV.Methods: This study was carried out in 50 confirmed type 2 diabetic patients matched for age, sex, duration and ABI >0.9 irrespective of the presenting complaints. Patients with either limb amputation, other reasons for peripheral neuropathy, ABI <0.9, critical and comatose were excluded. A complete neurological assessment using a symptom questionnaire, Semmes Weinstein monofilament, vibration and thermal threshold perception analyzer was done and recorded. A score was given out of 20. The patients were retrograde subjected to NCV by a blinded technician and the readings were then compared to the scores.Results: The level of significance between the total neuropathy score and the presence of neuropathy (by NCV) was very significant (p<0.0001) with an association of 0.932. In patients with a mean total neuropathy score of 3.28,10.80 and 15.37, there was no, mild and severe levels of neuropathy in NCV respectively.Conclusions: There is correlation between the total neurological scores and NCV. Therefore, it can be used to screen all diabetic patients for earliest signs of diabetic neuropathy with sustainable results.
Extrarenal angiomyolipoma in uterine cervix: rare presentation in unusual site
Authors: Monteiro Rashmi , Sharma Shikha , Gupta Sonal , Choudhary Indu
Published: December 2019

Angiomyolipoma is a benign neoplasm composed of variable admixture of blood vessels, smooth muscle cells and adipose tissue. Cervical angiomyolipoma are extremely rare and to the best of our knowledge only five cases of angiomyolipoma in cervix have been reported in the literature till date. Authors are presenting a case of angiomyolipoma arising from the uterine cervix. 43 years old female presented with mass descending per vagina for 6 months. This case had no association with tuberous sclerosis. Microscopic examination showed an ill-defined polypoidal, non-encapsulated lesion covered by keratinized stratified epithelium. The lesion is made up of three components, predominantly by fascicles of spindle shaped cells, varying sized blood vessels and multiple foci of mature adipocytes with no evidence of atypia or increased mitotic activity. Smooth muscle component showed strong immunoreactivity to SMA and absence of elastic fibres in the blood vessels were confirmed by histochemistry. Non-vascular smooth muscle cells were negative for HMB-45 in contrast to renal and other extra-renal angiomyolipoma in which HMB-45 immunoreactivity in seen in these cells. To conclude, the differential diagnosis of lower abdominal mass and dysfunctional uterine bleeding should include the angiomyolipoma, even though the uterine cervix is an extremely rare location where they occur.
Comparative study between laparoscopic trans-abdominal preperitoneal and open mesh hernioplasty in repair of non-complicated inguinal hernia
Authors: Sherpiny Waleed Yusif El
Published: December 2019

Background: Inguinal mesh hernioplasty is one of the common procedures performed all over the world. It can be done either through open or laparoscopic techniques. The aim of this study was to compare the outcomes of Lichtenstein tension free hernioplasty versus laparoscopic transabdominal pre-peritoneal (TAPP) mesh repair considering, duration of the surgery, hospital stay, and duration to resume normal activity, degree of postoperative pain, wound infection, recurrence and complications.Methods: Adult patients presented to the general surgical OPD, with the diagnosis of inguinal hernia underwent either Lichtenstein repair or laparoscopic repair by TAPP.Results: Patients in Group A (open-repair) had significantly greater level of local pain during rest and during routine activities than those within Group B (laparoscopic group) during the postoperative period assessed on the visual-analogue scale. Mean operative time for open hernia repair was 43.7 minutes and for laparoscopic hernia repair was 59.03 minutes and the difference were statistically significant (p=0.0001). The mean duration of hospital stay for open hernia repair was 2.16 days and that for laparoscopic hernia repair was 1.08 days with a (p=0.00001) which was statistically significant. The time to resume routine activities was much shorter among Group B patients than patients in Group A. Only one recurrence (3.3%) was seen in Group B after 6 months follow up.Conclusions: It is concluded that laparoscopic TAPP repair of inguinal hernia in adults is safe and preferred operation as compared to open inguinal hernia repair.
Cost-effectiveness analysis of serological prenatal screening for pregnant women in King Abdulaziz University Hospital: a single-center retrospective study
Authors: Saeed Asiri Atheer Yahya , Alsawa Ibtisam Talak Audallah , Fallatah Anas Mahmoud Omar , Hussein Sondos Sami , Alshehri Hisham Z. , Aljahdali Aseel Ahmed Mohammedali , Fatani Arwa Zuhair , Albasri Samera
Published: December 2019

Background: Congenital primary infections with Toxoplasma gondii, cytomegalovirus (CMV), Epstein–Bar virus (EBV), rubella, and hepatitis B virus (HBV) are viral infections transmitted transplacentally through the blood to the fetus and can be life-threatening. Therefore, we aimed to determine the prevalence of these infections and assess the cost-effectiveness of blood tests among pregnant women with positive serologies.Methods: This retrospective review was conducted among pregnant women with positive prenatal screening serology test results between January 2013 to July 2018. A p-value of <0.05 was used to calculate statistical significance.Results: Overall, 9095 pregnant women delivered in the last 5 years. Of these, 97 had positive prenatal screening serology and were enrolled in our study. Of 97, 61 (62.9%) were Saudis and 36 (37.1%) non-Saudis. The prevalence rates of rubella, CMV, EBV, and HBV were 78.35%, 59.79%, 14.43%, and 5.15%, respectively. Additionally, 44 of 97 women developed undesired antepartum outcomes, whereas 47 had adverse neonatal outcomes. CMV, HBV, and rubella were significantly associated with adverse pregnancy outcomes (P<0.005). During the study period, USD 1460228.27 was spent to screen 9095 pregnant women and USD 15573.68 to diagnose 97 pregnant women with positive serology.Conclusions: Because infections with toxoplasma, CMV, EBV, rubella, and HBV can cause serious risk to the mother and fetus during pregnancy. Thus, setting new hospital policies regarding early screening for high-risk pregnancies and early detection of these infections during prenatal visits are inevitable to avoid undesired outcomes.
Knowledge and preventive practices regarding dengue in an urban area of Palakkad
Authors: Chakkanmattil Sreedevi , Zachariah Shilu M. , Soman Deepak Kuttikatt , J. J. Jayalekha , K. P. Athira , Naina Marie J.
Published: December 2019

Background: Dengue is the most rapidly spreading viral disease in the world. Kerala had reported high incidence of dengue cases recently including deaths. Integrated vector management is the most effective method of vector control which requires community participation. As high incidence of dengue cases are reported in Palakkad district, it is imperative to assess the knowledge level and preventive practices followed by the community. This will help to formulate further action plans including awareness creation and behaviour change.Methods: A cross sectional study was conducted in two randomly selected wards of Palakkad municipality from July to August 2017. An adult from each household was interviewed using a semi-structured questionnaire. The household and its surroundings were also observed to identify breeding sources and calculate relevant vector indices.Results: 95.9% of informants knew that dengue is transmitted through bite of infected mosquito. 67.8% felt that dengue mosquito bites during the daytime. 53.0% of the families observed dry day practices. 15.8% used mosquito repellent creams and only 25.9% used mosquito nets. The house index, container index and breteau index were found to be 24.60%, 23.55% and 33.43% respectively.Conclusions: The awareness regarding modes of transmission and biting time of Aedes mosquito is good but the usage of personal protective measures is quite low. Although majority of the respondents had knowledge about breeding places, there were significant numbers of breeding sources especially plastic containers. Vector indices were also high indicating risk of transmission of dengue.
Prevalence and pattern of self-medication among urban population Chidambaram: a cross-sectional study
Authors: Gowthaman R. , Viknesh Ambayiram A.
Published: December 2019

Background: Self-medication as the selection and use of medicines by the individuals to treat self-recognised illness or symptoms. Self-medication is recognised as a part of self-care. The objectives of this study was to find out the prevalence of self-medication in an urban Chidambaram, Tamil Nadu, to find out the pattern of self-medication with regard to its practice and to find out the reasons favoring the practice of self-medication.Methods: The cross-sectional study was carried out in the month of September 2018 in a randomly selected urban field practice area of a tertiary care hospital. The sample size was calculated to be 360. Data was collected from all the houses in the selected field practice area. The data collected was entered into Microsoft excel spread sheet 2018 and analysis was done using SPSS version 21.Results: Self-medication was practiced by 195 (48.75%) of the households and 215 (18.6%) of the study participants. 42.1% reported pharmacist as source of knowledge. Most common symptom/sign for which self-medication was practiced was fever (42%). Most commonly (57.9%) used self-medicament was non-steroidal anti-inflammatory agents. Antibiotics were used by 15.4% as self- medicament. Among the 195 households practising self-medication, 65 (33.3%) reported that accessibility to pharmacy was more than that of clinic as reason for practicing self-medication.Conclusions: The usage of antibiotics as self-medicament and decreased awareness regarding the side effects of self-medicaments indicated decreased practice of responsible self-medication in the study area. More studies have to be conducted regarding the awareness, barriers and facilitators for practicing responsible self-medication.
Exploring the institutional sustainability of adolescent reproductive and sexual health program in Tripura
Authors: Baidya Subrata , Reang Taranga , Chowdhury Purvita , Paul Debosmita
Published: December 2019

Background: Adolescents are at the peak of growth velocity and warrant special consideration as they undergo enormous psychological, physical as well as cognitive changes. The Government of India implemented friendly adolescent reproductive and sexual health (ARSH) clinics to improve healthcare services all over the country. However, there is lack of information on the sustainability of the programme.Methods: Community workers and public health workers from randomly selected twenty sub centres for intervention from West Tripura district and control from the adjacent Khowai district were selected. Knowledge prior and post intervention at both sites of the health workers was assessed by a self-administered questionnaire on 0 day, at 3, 6 and 12 months. Difference of knowledge score was analysed by paired t-test.Results: The mean knowledge score significantly differed at pre-intervention and immediately post intervention (p<0.01). The knowledge score was sustained even after 12 months of intervention among public (14.63±3.01) and community health workers (12.53±2.91). However, at the control site, a gradual decrease was noted over duration of 12 months. Intervention also considerably increased the utilization of ARSH clinics by both male and females in comparison to previous year’s data.Conclusions: The intervention and increased sustainability of acquired knowledge over 12 months seem to enhance the capacity for the adolescent clinics. Therefore, training the health workers to manage various sexual and reproductive health issues along with creating a friendly environment for adolescents is indispensable in the present setting.
Comparative study of pap smear and colposcopy guided biopsy in a district medical college
Authors: Subramanyam Bhanu Rekha , Garlapati Hemasree
Published: December 2019

Background: Cancer cervix is the second most gynaecological and in India, one in fifty women suffer with cancer cervix and hence intense screening is mandatory.Methods: This prospective study was conducted in SVS Medical College, a district tertiary centre. 100 women who presented to gynaecology outpatient department who fulfilled all the inclusion criteria were subjected to pap smear and colposcopic guided biopsy. The data was correlated and compared to critically evaluate the sensitivity and specificity of colposcopy versus Pap smear in the early detection of dysplasia.Results: Colposcopy has far better sensitivity than Pap smear and almost negligible difference in specificity.Conclusions: Colposcopy is definitely more sensitive and accurate than pap smear and can be included as the primary screening in district hospitals as a primary screening tool in detecting cancer cervix.
Elaboração e aceitabilidade de macarrão tipo espaguete enriquecido com farinha de erva-sal (Atriplex nummularia L.)
Authors: Araujo Rodrigues Thais Jaciane , Vieira Agdylannah Felix , Dos Santos Trindade Aline Chiara , Rocha Ana Paula Trindade , Gouveia Deyzi Dos Santos , De Oliveira Vanessa Fernandes
Published: December 2019

The objective of this experiment was to dry the leaves of salt grass (Atriplex nummularia) and to make pasta with partial substitution of wheat flour for salt-grass meal. The leaves, with an initial water content of 77%, were submitted to kiln drying with forced air circulation at 60 ° C. Spaghetti-type pasta was prepared in 0, 5, 10 and 15% wheat flour combinations and subjected to microbiological evaluation according to the current legislation, which resulted in satisfactory sanitary and hygienic conditions. The sensorial test was performed with 50 untrained judges, and we observed that the standard formulation, without the addition of the salt-grass meal had the highest scores in all the attributes evaluated while the formulation with 15% of saltgrass meal had the lowest scores. The study showed that percentages of less than 15% salt grass meal have good consumer acceptability. Regarding firmness, there has been an increase in it with the addition of salt-grass meal.
Comportamento ingestivo de caprinos em caatinga raleada e enriquecida com capim corrente (Urochloa trichopus Stapf) e submetidos à suplementação
Authors: Nascimento George Vieira do , Pereira Filho José Morais , Gama Jean Francisco Pereira , Dantas Nayanne Lopes Batista , Silva Francisco Dyrlley Andrade da , Dias Diane Cristina de Araújo
Published: December 2019

The objective of this study was to evaluate the ingestive behavior of grazer goats and goats in feedlot, receiving supplementation in thinned caatinga enriched with Urochloa trichopus Stapf grass. The animals were kept under pasture from 8am to 4 pm, period in which it was assessed the grazing, rumination and idleness of 24 crossbred F1 goats (Boer x SPRD). They were evaluated at 10-minute intervals, under four levels of supplementation (0%, 0.5%, 1% and 1.5%). Evaluation of feedlot behavior took place between 4 pm and 8am. The animals activities were analyzed at 5-minute intervals during concentrate consumption and every 10 minutes after consumption, with three levels of supplementation (0.5%, 1% and 1.5%). We used a completely randomized design with 4 treatments and 6 replications for grazing behavior and 3 treatments and 6 replications for confinement behavior and the data were analyzed by regression at 5% probability. Supplementation decreased ingestion time on grassland and increased rumination time. As for feedlot behavior, supplementation increased ingestion time and decreased time spent in rumination.
Exigências nutricionais de cálcio para vacas leiteiras na microrregião de Sousa-PB a partir do uso de aplicativo para smartphone
Authors: Rodrigues Gilderlândio Pinheiro , Fernandes Beatriz Dantas , Dos Santos Lima Jéssica Monique , Da Silva Bismark Alves , Da Silva Daniel Cézar , Do Nascimento Júnior Marcos José
Published: December 2019

Technological innovation has had a remarkable rise and its use in rural areas has become a subdisidiary method for both producers and professionals in the agrarian area. In dairy cattle, there is a lack of information about nutritional management. The supply of minerals is inadequate and it does not meet the requirements of animals often. The objective of this study was to develop an application to estimate the nutritional requirements of calcium for dairy cows and to help producers to provide adequate amounts of this mineral. The application was created from the Java platform, using recommendations from the National Research Council (NRC), with calculation of requirements for maintenance of lactating and non-lactating cows, females in growth, gestation. The application enables the filling of data from animal characterization to the type and quantity of concentrate and forage provided. After filling the data the application will generate the result informing whether the cow in lactation has a deficit, surplus or if it is receiving adequate amounts of the mineral. It also demonstrates the amount of calcium that should be increased or decreased, according to the needs of each animal. Using the bovine calcium application, producers will provide an appropriate supplement, reducing unnecessary costs and increasing milk production.
Estágio docente no curso de Administração: uma análise da atividade do discente-professor
Authors: Costa de Araujo Paula Mara , Bianco Monica De Fátima , Teixeira Valadão Kleyton , Boreli de Anchieta Rebeca
Published: December 2019

The aim of this research was to understand the process of training university professors through the teaching internship in the PhD Course in Administration in a Brazilian public university. The research was based on the theoretical-analytical contribution of ergology and on the analysis of the work activity of “teacher-students” in the first semester of 2018 to understand how they put their values, choices and beliefs in their actions before a set of established norms and organizational context. The results of this research point out that the participants realize the relevance of the teacher’s role and the interpersonal relations in the context, giving importance to their relations with the students and demanding a greater interaction with the tutor-teacher, as well as with the coordination of the program in order to cooperate with the teacher training process. They use their formal and informal knowledge, reflect on the dynamics of learning how to teach, although they are concerned with previous norms, they do not hesitate to change their work form to better adjust the methodology and content to the students and their singularities.
Destinação de recursos de um banco de desenvolvimento: uma análise do perfil de financiamentos do BNDES
Authors: Saturnino Odilon , Silva Edmilson Junior Bezerra da , Bizerril Danielly Fernandes , Silva Ismael Martins da , Barbosa Laís De Mendonça
Published: December 2019

Compounding a research line of Auditory and Controlling in the Public Sector of the Public Administration Perspectives Observatory, this project aimed to make an analysis of the financing profile of the Economic and Social Development National Bank – BNDES, having as focus its function as a financial banking institution of development and support to the public sector and small organizations. The methodological approach used was quantitative. The study examined non automatic data related to BNDE’s financing direct and indirect operations and direct and indirect operations with Public Administration, from 2002 to 2018. So, it is census, with econometric analysis of secondary data obtained in BNDES Transparency site. Variables that characterize BNDES as a development institution (especially to cities in the countryside and small organizations) have been identified.
The Study of Water Sorption with Hydrolysis Lignin by Solid-State NMR Spectroscopy
Authors: Shestakov S.L. , Popova Yu.A. , Kozhevnikov A.Yu. , Kosyakov D.S. , Sypalov S.A.
Published: December 2019

Hydrolysis lignin is formed as a by-product of cellulose production and has limited industrial application. The ability of hydrolysis lignin to absorb and retain some water is important aspect for the study of its properties and modification methods. The processes of water sorption by hydrolysis lignin were studied with solid-state NMR spectroscopy. The samples were humidified in desiccators containing different saturated salts solutions with different relative air humidity above them. The sorption capacity of the samples was determined by water sorbed from the air, and it was found that lignin absorbs the amount of water equal to 40% of sample weight at maximum relative humidity of the air. The cross-polarization (CP) and magic angle spinning (MAS) methods were used to register solid-state NMR spectra. Using the 1H-NMR spectra, it was found that the hydrolysis lignin is hydrated in the whole volume, and the water penetrates into the deep layers of polymer, however, the distribution of water at the likely sorption sites is uneven. It was obtained with use of 13C-NMR spectroscopy that hydrolysis lignin hydrates in both hydrophilic and hydrophobic regions of the macromolecule, and the bulk of sorbed water (~64%) concentrates around the hydroxyl and methoxyl groups of lignin and polysaccharide residues.
Pendekatan kriminologi dan gender terhadap model kurikulum pembinaan narapidana anak kelas I Blitar
Authors: Saifullah Saifullah
Published: December 2019

This study is aimed to elaborate the criminology and gender approaches taken to provide curriculum material contents in forming curriculum models for fostering child detainees in the child prison. Using legal and conceptual approaches, this study elaborates the findings as follows: in the criminology perspective, to provide curriculum material contents in forming curriculum models for fostering child detainees in child prison is by using religious approach, completing facilities and infrastructures, optimizing employee roles, applying formal education in prison, giving treatment and health care, supporting for the creation of social recovery, giving  remission of crimes and assimilated opportunities including a leave to visit family or parole and a leave before being released. Whereas, in the gender perspective, it is by not distinguishing between sexes during the treatment to them. In addition, the final result of the curriculum model formation for fostering child detainees in child prison of LPKA (Child-specific Guidance Institution) in Blitar can be referred to as; the treatment system for correctional students in prison. This system consists of input in the form of an initial stage of 0 to 1/3 course with an administrative orientation pattern; the advanced stage consists of 1/3 to ½ course and ½ to 2/3 course; the final stage is 2/3 to any uncertain course stage with the achievement of correctional goal that is social reintegration: live, life, livelihood.
DISTINCTIVE PERSONALITY TRAITS OF PRESENT-DAY ADOLESCENTS –ACTIVE USERS OF SOCIAL MEDIA
Authors: N. Tkach Elena , V. Sitnikova Elena
Published: December 2019

Purpose of the study: To Reveal and describe the distinctive personality traits of today’s adolescents who are active users of social media.

Methodology: The major methods employed to explore the researched problem were the interview and testing which allowed revealing and scrutinizing the explored psychological and pedagogical phenomena.

Main Findings: It was revealed that today’s adolescents who actively use social media have the proclivity for submission, rejection of responsibility and leadership, describe themselves as being selfish, self-centered, having an inclination towards rivalry and dominance, while their agemates perceive themselves as being friendlier and less inclined to dominance. This paper explains that the active use of social media by the adolescents today is driven by their need for communication, high levels of anxiety and determination to preserve their individuality. Teenagers who actively use social media are sensitive, impulsive, and expressive, have low self-control, maybe confrontational, tend to be self-indulgent and seek benefits in different life situations. The active use of social media is related to a strongly expressed keenness of the teenagers to communicate, while at the same time they have low motivation for spiritual self-fulfilment in the area of public activity.

Applications of this study:  The applications are that the obtained results may be used in the psychological and pedagogical practice of work with adolescents, their parents, and teachers, as well as for professional training and qualification upgrade of teachers and psychologists.

Novelty/Originality of this study: The novelty of this study is that it allows for a deep psychological analysis of determinants and predictors of problems and difficulties faced by today’s teenagers.
CORPORATE SOCIAL RESPONSIBILITY AS A RESERVE FOR THE GROWTH OF ENTREPRENEURIAL ACTIVITY IN THE RUSSIAN ARCTIC
Authors: Skufina Tatiana , Bazhutova Ekaterina , Samarina Vera , Serova Natalia
Published: December 2019

Purpose of the study: To explore the consists of studying the opportunities for unlocking the potential of carrying out an entrepreneurial activity of big business within the Russian Arctic as a part of corporate social responsibility policy conducted by it.

Methodology: The leading approach identified is the integrated approach which includes theoretical generalizations, analysis of practical activities of the corporations, and sociological methods of obtaining the information.

Main Findings: The main concepts of big business management that contribute to boosting its entrepreneurial activity have been discussed, and opportunities for enhancing the entrepreneurial activity of big business within the Russian Arctic as a constituent of the corporate social responsibility policy have been found.

Applications of this study: The materials of the paper are of practical importance for corporations working within the Russian Arctic.

Novelty/Originality of this study: In the work, models of corporate social responsibility implemented by corporations of the Arctic states have been summarized.
Desempenho Mercadológico no Mercado de Alta Tecnologia: Uma Revisão Sistemática
Authors: Goulart Gislayne da Silva , Weber Alessandra Ferrari , Porto Rafael Barreiros
Published: December 2019

Objetivo: Analisar a produção científica relativa ao desempenho mercadológico no mercado de alta tecnologia no período de 1997 a 2019.Método: Foram utilizadas as metodologias de bibliometria e revisão sistemática. O processo de busca foi realizado nas bases Web of Science e SPELL e resultou na seleção de 23 artigos dentro do escopo definido, dentre 82 estudos. Os estudos selecionados foram analisados por meio de estatística descritiva, Classificação Hierárquica Descendente (CHD) e Análise Fatorial de Correspondência (AFC).Principais resultados: Os resultados apontam um recente interesse sobre a mensuração de desempenho no mercado de alta tecnologia, sobretudo nos mercados emergentes como Taiwan e China, com o uso de indicadores multidimensionais, financeiros e não financeiro. Por meio das análises de CHD e AFC observou-se a formação de quatro Classes – ‘Habilidades internas’, ‘Alianças’, ‘Foco a jusante’ e ‘Foco a montante’ – cujas temáticas predominantes explicitam os focos de interesse associados ao desempenho mercadológico no mercado de alta tecnologia.Relevância/originalidade: O estudo inova ao propor um protocolo para realizar análises textuais de artigos científicos com auxílio do software Iramuteq, possibilitando a identificação dos diferentes enfoques dos estudos e agrupamento por semelhanças.Contribuições: É proposta uma agenda de estudos futuros em função dos resultados e de lacunas sobre desempenho e indicadores utilizados pelas empresas no mercado de alta tecnologia. Sob o prisma gerencial, destaca-se que os indicadores mais utilizados nesse mercado são as vendas, a participação de mercado e o desempenho de novos produtos.
Obezitenin Tedavisinde Geçmiş ve Güncel Bariatrik Cerrahi Uygulamaları
Authors: GÜNGÖR Şeyda
Published: December 2019

Obezite; çağımızın görülme sıklığı hızla artmakta
olan kronik ve kompleks bir hastalığıdır. Obezitenin kanser, metabolik sendrom,
tip 2 diyabet gibi bazı hastalıkların yanında kardiyovasküler, renal ve muskuloskeletal sistem bozukluklarının, psikolojik rahatsızlıkların ve
diğer birçok işlevsel bozukluğun artışında etkisinin olduğu günümüz
literatürünce kabul edilmiştir. Obezitenin tedavisinde düzenli
fiziksel aktivite eşliğinde sağlıklı diyet uygulamalarının veya medikal
tedavilerin sonuç vermediği durumlarda; donanımlı merkezlerde deneyimli ekipler
tarafından bariatrik cerrahi uygulamaları gerçekleştirilmektedir. Sürecin
başarılı geçmesi hastaya en uygun bariatrik cerrahi uygulamasına karar
verilmesi ve süreç boyunca sürekli beslenme ve metabolik takip ile mümkündür.
Her bir uygulamanın ise avantajları ve dezavantajları mevcuttur. Bu derlemede bariatrik cerrahinin
eski ve yeni uygulamaları hakkındaki genel bilgiler bir araya getirilmiştir.