bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel mouse strains to study circulating permeability factor(s) in primary focal segmental glomerulosclerosis
Authors: den Braanker Dirk , Maas Rutger , Parr Naomi , Deegens Jeroen , Smeets Bart , Wetzels Jack , van der Vlag Johan , Nijenhuis Tom
Published: September 2022

Recurrence of proteinuria after kidney transplantation in primary focal segmental glomerulosclerosis (FSGS) is unpredictable. Several putative circulating permeability factors (CPFs) have been suggested, but none have been validated. A clinically relevant experimental model is required that demonstrates the presence of CPF(s) in patient material, to study CPF(s) and possibly predict recurrence in patients. We aimed to develop a FSGS-prone Thy-1.1 transgenic mouse model with accelerated proteinuria after injection of samples from patients with FSGS. The Thy-1.1 transgene was backcrossed into 5 mouse strains. The age of onset and severity of spontaneous proteinuria varied between the different genetic backgrounds. 129X1/SvThy-1.1 and 129S2/SvPasThy-1.1 mice displayed proteinuria at 4 weeks, whereas Balb/cThy-1.1 and C57BL/6JThy-1.1 mice developed proteinuria from 6 weeks, and were used further. We determined the maximum protein dose that could be injected without causing protein overload in each background. Balb/cThy-1.1 and C57BL/6JThy-1.1 males and females were injected with presumably CPF-containing plasmapheresis effluent from 6 FSGS patients, which induced albuminuria particularly in Balb/cThy-1.1 males. Unfortunately, no response could be detected when using sera instead of plasmapheresis effluent, serum being more clinically relevant in the context of predicting FSGS recurrence. Considering the differences between responses elicited by serum and plasmapheresis effluent, simultaneously collected serum, plasma, and plasmapheresis effluent were tested. Whereas we could detect responses using a validated in vitro model, none of these presumably CPF-containing samples induced proteinuria in Balb/cThy-1.1 males. Thus, we have extensively tested the Thy-1.1 mouse model on different genetic backgrounds with proteinuria after injection of FSGS patient material as clinically relevant readout. The Balb/cThy-1.1 male mouse strain demonstrated the most promising results, but to detect CPF activity in FSGS serum e.g. prior to kidney transplantation, this strain clearly lacks sensitivity and is therefore not yet clinically applicable. It could, however, still be used as research tool to study CPFs in patient samples that did induce proteinuria.
Femoral fixation methods for hamstring graft in anterior cruciate ligament reconstruction: A network meta-analysis of controlled clinical trials
Authors: Nie Shixin , Zhou Shuqing , Huang Wei
Published: September 2022

Objective

To compare the clinical effectiveness of cortical button (CB), cross-pin (CP) and compression with interference screws (IS) fixation techniques in anterior cruciate ligament (ACL) reconstruction using hamstring graft.

Methods

Studies were systematically retrieved from PubMed, Embase, Cochrane Library and Web of Science up to May 20, 2021. Primary outcomes were KT-1000 assessment, International Knee Documentation Committee (IKDC) score A or B, Lachman’s test, pivot-shift test, visual analogue scale (VAS) score, Lysholm score, Tegner score, and Cincinnati Knee Score. Secondary outcomes included reconstruction failures and synovitis. League tables, rank probabilities and forest plots were drawn for efficacy comparison.

Results

Twenty-six controlled clinical trials (CCTs) with 1,824 patients undergoing ACL reconstruction with hamstring graft were included. No significant differences were found among CB, CP and IS fixation methods regarding the 10 outcomes. For KT-1000 assessment, IKDC score A or B, Lachman’s test, VAS score and pivot-shift test, CP had the greatest probability of becoming the best method, and IS may be the suboptimal method in 4 out of these 5 outcomes except pivot-shift test.

Conclusions

CP, CB and IS fixations have comparable clinical performance, while CP fixation is most likely to be the optimum fixation technique for hamstring graft in ACL reconstruction. Future larger-sample studies of high quality comparing these techniques in more clinical outcomes are required.
Knockout of liver fluke granulin, Ov-grn-1, impedes malignant transformation during chronic infection with Opisthorchis viverrini
Authors: Chaiyadet Sujittra , Tangkawattana Sirikachorn , Smout Michael J. , Ittiprasert Wannaporn , Mann Victoria H. , Deenonpoe Raksawan , Arunsan Patpicha , Loukas Alex , Brindley Paul J. , Laha Thewarach
Published: September 2022

Infection with the food-borne liver fluke Opisthorchis viverrini is the principal risk factor for cholangiocarcinoma (CCA) in the Mekong Basin countries of Thailand, Lao PDR, Vietnam, Myanmar and Cambodia. Using a novel model of CCA, involving infection with gene-edited liver flukes in the hamster during concurrent exposure to dietary nitrosamine, we explored the role of the fluke granulin-like growth factor Ov-GRN-1 in malignancy. We derived RNA-guided gene knockout flukes (ΔOv-grn-1) using CRISPR/Cas9/gRNA materials delivered by electroporation. Genome sequencing confirmed programmed Cas9-catalyzed mutations of the targeted genes, which was accompanied by rapid depletion of transcripts and the proteins they encode. Gene-edited parasites colonized the biliary tract of hamsters and developed into adult flukes. However, less hepatobiliary tract disease manifested during chronic infection with ΔOv-grn-1 worms in comparison to hamsters infected with control gene-edited and mock-edited parasites. Specifically, immuno- and colorimetric-histochemical analysis of livers revealed markedly less periductal fibrosis surrounding the flukes and less fibrosis globally within the hepatobiliary tract during infection with ΔOv-grn-1 genotype worms, minimal biliary epithelial cell proliferation, and significantly fewer mutations of TP53 in biliary epithelial cells. Moreover, fewer hamsters developed high-grade CCA compared to controls. The clinically relevant, pathophysiological phenotype of the hepatobiliary tract confirmed a role for this secreted growth factor in malignancy and morbidity during opisthorchiasis.
La provisión de apoyos fuera del aula como medida de atención a la diversidad y sus efectos en la inclusión educativa
Authors: Rodríguez Gudiño Margarita , Jenaro Río Cristina , Castaño Calle Raimundo
Published: September 2022

Este estudio analiza el impacto del apoyo fuera del aula como medida de atención a la diversidad en el alumnado de primaria, además de las nominaciones positivas y negativas que emiten y reciben, así como sus perfiles sociométricos. La muestra representa a 20 colegios ordinarios de la región de Extremadura (España). Participaron 881 alumnos (de 6 a 12 años) pertenecientes a 43 aulas de primaria, de primero a sexto curso; de estos, 98 alumnos (11,12 %) presentaban necesidades específicas de apoyo educativo. Como instrumento se utilizó un cuestionario sociométrico basado en el método de nominación de iguales y la asociación de atributos. Los resultados muestran que los alumnos con necesidades específicas de apoyo educativo (ACNEAE) obtienen más rechazo y que este aumenta a medida que lo hace el nivel educativo. Además, estos alumnos reciben más nominaciones por parte de sus iguales con NEAE. Los alumnos con y sin NEAE muestran perfiles sociométricos distintos que denotan perfiles comportamentales diferentes. Los resultados muestran que la provisión de apoyos fuera del aula parece actuar como factor inhibidor de la inclusión educativa.
The evolution of the local innovation agents (ALI) program methodology and its contribution to the innovation management at Medicatriz Dermocosmetics
Authors: Marengo Lívia Luize , Soares Allan Nunes , Romão Henrique Rafael da Silva , Araújo Davi Lucas Arruda de , Zilber Silvia Novaes
Published: September 2022

Objective: evaluate the influence of participation in cycles of the ALI Program in the innovative ambience of Medicatriz Dermocosmetics from 2013 to 2020. Investigated context: the basis of the ALI Program methodology was defined by eight premises: concrete results; use of indicators; results for Sebrae and the innovation ecosystem; involvement of the company's team; collective construction of solutions; tools; companies motivated to innovate; and ALI as a facilitator to overcome the dilemma of having a good creative potential, but without converting into innovations that provide increased sales. Intervention: adopt mechanisms to solve the diagnosed problems, some interventions of open innovation, co-creation, branding, ethnographic research, current customer, and employee satisfaction were proposed for each cycle of participation. Results: in the first cycle, eleven new products were launched using nanotechnology and sensory transversality; in the second, there was a sub-category of customers and humanized projects for customers, employees, and social circles; in the third, remodeling of workshops, creation of paid courses, school visits, supervised internship, and advanced support; and in the fourth, a model for recognizing employees was created. Conclusion: the promotion of the continued practice of innovation actions in small companies and contributions to Medicatriz permeated the four dimensions of innovation. The company understands that investment in human development increases the chances of organizations becoming productive and engaging for their employees, suppliers, and customers.
Molecular docking studies on the phytoconstituents as therapeutic leads against SARS-CoV-2
Authors: Tiwari Abhishek , Tiwari Varsha , Verma Navneet , Singh Anita , Kumar Manish , Saini Vipin , Sahoo Biswa Mohan , Kaushik Deepak , Verma Ravinder , Sagadevan Suresh
Published: September 2022

Because of the present pandemic researchers are seeking for phytocandidates that can inhibit or stop SARS-CoV-2. The main protease (Mpro) of SARS-CoV-2 and spike glycoprotein (S) are both suppressed by bioactive compounds found in plants that work by docking them together. The Mpro proteins 6LU7 (complex with an inhibitor N3) and 5C3N (space group C2221) were employed in docking research. PyRx and AutoDock Vina software were used as docking engine. 22 identified phytoconstituents were selected from IMPPAT, a manually curated database, on the basis of their antiviral effects. Docking studies showed that phytoconstituents β-amyrin (-8.4 kcal/mol), withaferin A (-8.3 kcal/mol), oleanolic acid (-7.8 kcal/mol), and patentiflorin A (-8.1 kcal/mol) had the best results against 5C3N Mpro protein whereas kuwanon L (-7.1 kcal/mol), β-amyrin (-6.9 kcal/mol), oleanolic acid (-6.8 kcal/mol), cucurbitacin D (-6.5 kcal/mol), and quercetin (-6.5 kcal/mol) against 6LU7 Mpro protein. All the compounds were examined for their ADMET characteristics using SwissDock. Present research reports that the phytoconstituents along with docking score will be helpful for future drug development against Covid-19.
Thermal Performance of Double Pass Solar Air Heater With Tubular Solar Absorber
Authors: Hussein Nassr Fadhil , Ahmed Sabah T , Ekaid Ali L
Published: September 2022

In this investigation, the effect of replacing the conventional solar absorber with a new solar absorber on the thermal performance of a double-pass solar air heater has been studied experimentally and numerically.  Three configurations have been introduced, the first configuration is a double pass solar air heater with a flat plate solar absorber (DPSAHWFP) for the aim of comparison, and the second configuration is a double pass solar air heater with a tubular absorber that includes a set of tubes which are fitted perpendicularly to the direction of airflow (DPSAHWT-1),  and the third configuration is double-pass solar air heater with a tubular absorber that involves set of tubes which are fitted in parallel to the direction of airflow (DPSAHWT-2). The experiments have been carried out under indoor conditions at a constant heat flux equal to 1000 W/m2 and different air mass flow rates (0.01– 0.03 kg/s). The results revealed that the air mass flow rate has a substantial impact compared to the rise in air temperature, hence, the thermal performance of solar air heater is directly proportional to increase air mass flow rate. In addition, the experimental and numerical outcomes indicated that for all air flow rates. The (DPSAHWT-2) offers higher thermal performance as compared to other models, where the maximum effective efficiency has been obtained at 0.03 kg/s equal to 80.9 %. Moreover, (DPSAHWT-2) is more efficient than DPSAHWFP and DPSAHWT-1 by 4.2 % and 9.8 % respectively.
Effects of exercise combined with diet intervention on body composition and serum biochemical markers in adolescents with obesity: a systematic review and meta-analysis
Authors: Zhao Liangyu , Dong Xiaosheng , Gao Yan , Jia Zhihao , Han Suyue , Zhang Juntao , Gao Yubo
Published: September 2022

Background

This systematic review aims to evaluate the effects of exercise combined with diet (ECWD), exercise alone, diet alone, and no intervention on body composition and serum biochemical markers in adolescents with obesity to provide reference for solving the metabolic disorders of adolescents caused by obesity.

Contents

Studies published before January 5, 2021 were retrieved from PubMed, Web of Science, Ovid, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wanfang data, VIP database, and SinoMed. Randomized controlled trials with an age between 10 and 20 years, body mass index (BMI) ≥28 kg/m2 or ≥95th percentiles, no history of endocrine and metabolic diseases, heart disease, hematologic disease, and so on before the trial were included.

Fifteen of the 50,155 studies met the criteria. Meta-analysis showed that ECWD was more effective in reducing BMI (kg/m2) (−2.45 kg/m2, 95% CI: −3.06; −1.85) and fat thickness of back (−13.77 mm, 95% CI: −15.92; −11.62), abdomen (−11.56 mm, 95% CI: −14.04; −9.09), and upper arm (−14.81 mm, 95% CI: −16.74; −12.89) than other interventions; in reducing body fat (−7.03 kg, 95% CI: −9.77; −4.29) and thigh circumference (−4.05 cm, 95% CI: −5.58; −2.52), ECWD and diet alone were more effective than exercise alone; ECWD and exercise alone were more effective in reducing waist circumference (−6.05 cm, 95% CI: −8.37; −3.72), waist-to-hip ratio (WHR; −0.06, 95% CI: −0.11; −0.01), upper arm circumference (−2.57 cm, 95% CI: −3.70; −1.45), triglycerides (TG; −0.30 mmol/L, 95% CI: −0.45; −0.14), total cholesterol (TC; −0.30 mmol/L, 95% CI: −0.59; −0.01), and low density lipoprotein (LDL; −0.22 mmol/L, 95% CI: −0.40; −0.04) than diet alone. ECWD also had effects on tumor necrosis factor-α (TNF-α), interleukin-6, leptin, and so on.

Outlook

ECWD is more effective than exercise alone, diet alone, or no intervention in solving the problems of body shape and metabolic disorder of adolescents with obesity.
Can interoceptive sensitivity provide information on the difference in the perceptual mechanisms of recurrent and chronic pain? Part I. A retrospective clinical study related to multidimensional pain assessment
Authors: Ciaramella Antonella , Pozzolini Valentino , Scatena Erika , Carli Giancarlo
Published: September 2022

Objectives

Although neurobiological research has shown that interoception plays a role in the perception of pain and its chronification, the relationship between interoceptive sensitivity and pain has not been definitively confirmed by clinical studies. The aim of this study was therefore to better understand the relationship between interoceptive sensitivity, somatization, and clinical pain, and to identify any differences in the interoceptive sensitivity of patients with recurrent vs. chronic pain.

Methods

Scores from 43 Chronic pain subjects, assessed using ICD-11 Criteria; 42 healthy subjects (without pain or psychiatric disorders); and 38 recurrent pain subjects on the Multidimensional Assessment of Interoceptive Awareness (MAIA), Body Perception Questionnaire (BPQ-SF), Somatosensory amplification scale (SSAS), Patient Health Questionnaire (PHQ-15), Symptom Checklist-Revised (SCL-90-R), and Italian Pain Questionnaire (IPQ) were compared.

Results

Negative attention to the body was indicated by higher scores of psychosomatic dimensions as SSAS, SCL90R somatization, and PHQ-15 in recurrent, but especially chronic pain (p<0.000 for all). An increase in psychosomatic dimension scores (i.e., somatization, somatosensory amplification) was associated with an increase in both autonomic nervous system reactivity (ANSR) dimension scores and the negative influence of the Not-worrying, attention regulation and trusting of the MAIA. In contrast, the presence of pain and scores for its dimensions with associated with lower supra-diaphragmatic activity as per the BPQ.

Conclusions

Pain chronification might depend on both the impairment of interoceptive sensitivity and an increase on psychosomatic dimensions via modification of ANSR hyperactivity and a reduction of the MAIA Not-worrying dimension.
Era uma vez a lembrança de uma árvore chamada "do esquecimento"
Authors: Araújo da Silva Renato
Published: September 2022

As disciplinas de história e antropologia no mundo todo tem como aliadas, entre outras, a arqueologia quando o objetivo é recuperar entre outros aspectos as diferentes materialidades dos povos colonizados. Calcados em trabalhos interdisciplinares tanto a cultura material, como a própria territorialidade, parte da memória atlântica e as profundas transformações identitárias estão sendo resgatados no contexto da chegada e permanência de milhões de africanos e afrodescendentes no período colonial brasileiro. Aquilo que outrora poderia ter sido um rompimento com uma memória de uma certa “África perdida”, recuperar-se-á pelo trabalho da arqueologia histórica e etnoarqueologia. Por meio de uma seleção pontual e não exaustiva e com objetivos de fomentar a discussão do problema, faremos aqui um panorama preliminar sobre alguns dos desafios para resgate arqueológico de materialidade e memória de herança africana no Brasil. Por fim traçamos um paralelo entre a destruição de sítios ao embotamento da memória provocada pela interpretação apressada do cruzamento de iconografias africanas e afro-brasileiras ou de alguns resultados científicos.
Juntando cacos
Authors: Cardoso de Mello Louise
Published: September 2022

Este artigo apresenta um estudo sobre as práticas materiais do processo etnogenético de configuração de comunidades negras rurais ao longo do século XIX no vale do baixo e médio Guaporé (atual estado de Rondônia), a partir da análise do material cerâmico histórico procedente do Forte Príncipe da Beira. Seu principal objetivo é refletir sobre o que a interseção de elementos indígenas, africanos e europeus identificados na cerâmica de barro cozida escavada no recinto intramuros nos diz sobre a persistência de comunidades de práticas e as dinâmicas sociais e interétnicas no Forte e seu entorno. Considerando a historicidade das terras de pretos ao longo do Guaporé, bem como a sobrevivência desses elementos culturais na cerâmica tradicionalmente produzida na região, o presente estudo dialoga com a literatura da Arqueologia da Persistência, propondo uma reconceituação em torno da noção de “reexistência”, em linha com as teorizações dos movimentos negros e indígenas, e as reivindicações de comunidades quilombolas.
Autodecolonização – Uma pesquisa pessoal no além coletivo
Authors: Makuxi Jaider Esbell
Published: September 2022

Resumo: Aplicar pesquisa em pensar a minha passagem no mundo como alguém minimamente consciente de si tem me levado a lugares surpreendentes. A dinâmica do me levar faz um movimento retroalimentar considerando que eu não iria sem meu coletivo anterior, isto seja, a minha identidade ancestral. Mais que um circuito entre ancestralidade e atualidade, essa questão é uma base para se navegar em águas revoltas, visto que, se não bem entendidas ou explicadas, essas duas palavras acabam por fazer parte do jogo epistemológico colonial.
 
Abstract: Applying research in thinking about my passage in the world as someone minimally aware of himself has taken me to surprising places. The dynamics of taking me make a feedback movement considering that I would not go without my previous collective, that is my ancestral identity. More than a circuit between ancestry and actuality, this question is a basis for navigating rough waters, since, if not well understood or explained, these two words end up being part of the colonial epistemological game.
Editorial
Authors: Guedes Milheira Rafael , Peretti Wagner Gustavo , Vergara Cerqueira Fábio
Published: September 2022

Sem resumo
Seed germination and salinity tolerance of habitat-indifferent halophytes as associated with geographical distribution
Authors: Gairola Sanjay , Hameed Abdul , Rasheed Aysha , Alketbi Asma , Aljasmi Mariam , El-Keblawy Ali
Published: September 2022

Germination response to environmental factors often depends on the seed source. Habitat-indifferent halophytes that can grow well under both saline (SH) and non-saline habitats (NSH) offer a good opportunity to understand salinity tolerance during the germination stage under varying
environmental factors, such as temperature and light. This study compared seed germination responses among different populations of two common habitatindifferent halophytes (Salsola drummondii and Suaeda vermiculata) from subtropical hyperarid deserts of the United Arab Emirates
(UAE) and semiarid warm sub-tropical areas in Pakistan. This study highlights many similarities and differences in the seed germination and recovery responses of habitat-indifferent halophytes occurring in two contrasting climatic regions. The germination window of UAE seeds was wider, i.
e., they germinated at higher rates under all temperatures in both light and darkness. This indicates that seeds of UAE populations can germinate at any time of the year, if conditions are optimal, and faciltate a faster seedling establishment under fluctuating harsh environmental conditions
compared to populations from semiarid warm sub-tropical areas in Pakistan. The eco-physiological significance of the responses is also discussed.
Digital Literacy and Long-Term Labor Outcomes
Authors: Meza-Cordero Jaime
Published: September 2022

Technological skills are critical for high-productivity occupations. Between 2012 and 2017, a selected group of primary schools in Costa Rica were provided with one laptop per enrolled student. This paper evaluates this ambitious intervention by elucidating the effects on students’ educational and labor market aspirations, school outcomes, and time allocation after six years of access to a computer with connectivity. Using baseline, midline, and endline primary data from program participants and a control group, and a difference-in-difference strategy, this study shows that the program influenced treated students to increase their school motivation, their target education completion, and their intention to migrate in adulthood. The results do not find conclusive evidence of positive change toward pursuing computer science-related occupations or office-based jobs. The findings show evidence of a significant increase in computer usage for treated children but no impacts on the time spent performing homework, outdoor activities, and home chores.
Enzymatic saccharification of eucalyptus chips with a pretreatment process using NH4Cl
Authors: Huo Dan , Wang Dongsheng , Yang Qiulin , Si Chuanling , Liu Qiujuan , Li Bin , Zhang Fengshan
Published: September 2022

NH4Cl was used to optimize the pretreatment conditions for biomass pretreatment to improve enzymatic saccharification and hemicellulose degradation of eucalyptus chips. After pretreatment, the solid substrate (SS) and pretreatment liquor (PL) were characterized, and the SS was enzymatically hydrolyzed to detect the conversion yield of cellulose (CYC). For the pretreatment using NH4Cl, the removal rate of hemicellulose reached up to 100% in some cases, but a great proportion of cellulose remained in the SS. The optimized conditions for pretreatment using NH4Cl were 0.3 M NH4Cl at 200 °C for 25 min. A comprehensive evaluation found that the most suitable severity parameter for pretreatment and enzymatic saccharification was 4.5, although a higher severity parameter could increase the CYC. XRD and FTIR analysis showed that the pretreatment had little influence on the cellulose crystalline region, and the lignin was well-retained in the pretreatment process.
Physical and mechanical properties of boards made from modified rapeseed straw particles
Authors: Hýsek Štěpán , Sikora Adam , Schönfelder Ondřej , Böhm Martin
Published: September 2022

Composites made from annual plants, such as winter rapeseed, can be used as an alternative to wood-based composites because of their ecological character, low price, as well as physical and mechanical properties. The goal of this study was to prepare such boards and evaluate their properties. Unmodified material and chemically and hydrothermally modified rapeseed particles glued by powder polyester glue were used. The characteristics measured were the internal bonding, swelling and moisture uptake over time, and surface soundness. The results showed that modification of the raw material influenced the properties of the resulting composites. The highest swelling values were exhibited by the boards with particles that were alkaline-modified. Boards made from hydrothermally modified particles achieved the highest strengths compared with the commercially produced boards. The alkaline modification of the particles resulted in a stronger adhesive bond between the particle and adhesive. During the internal bonding test, the boards made from the alkaline-modified particles exhibited cohesive failures in the particles. Therefore, the modification of the particles increased the mechanical properties of the boards, but the physical properties deteriorated.
Determination of Vibration Object’ Coordinate on Surface of Earth
Authors:   International Research and Training Centre of Information Technologies and Systems of the NAS and MES of Ukraine, Zelinsky Volodymyr A. , Lуsochenko Serhii V. ,   Educational and Scientific Institute of High Technologies of Taras Shevchenko National University of Kyiv, Ilchenko Volodymyr V. ,   Educational and Scientific Institute of High Technologies of Taras Shevchenko National University of Kyiv, Nikiforov Mykola M. ,   Military Institute of Taras Shevchenko National University of Kyiv, Kulsky Oleksandr L. ,   Educational and Scientific Institute of High Technologies of Taras Shevchenko National University of Kyiv, Krychta Vitaliy V. ,   Educational and Scientific Institute of High Technologies of Taras Shevchenko National University of Kyiv
Published: September 2022

The problem of determination of vibrating object’s coordinates on Earth’s surface is considered for the case in which generated seismic waves are measured with several probes. Analytical dependencies of vibrating object’s coordinates as functions of the probes’ coordinates, relative delays of the wave front for different probes, and velocity of its propagation are obtained. Configurations involving three and four probes are being investigated, calculations’ algorithms and codes are described, and the accuracy of the coordinate’s determination is studied.
The benchmark for VAT and VAT expenditures in Ukraine: methodological and pragmatic aspects
Authors:   State Educational and Scientific Institution ", Sokolovska Alla ,   Academy of Financial Management"
Published: September 2022

Despite the preparation by the State Tax Service of Ukraine of Reports on tax reliefs that are a loss of budget revenues, which indicate certain steps towards the introduction of the concept of tax expenditures in the budget process, the question of their quality remains open due to the uncertainty of the principles of distribution of tax reliefs into those that are losses of budget revenues and other tax reliefs, and due to the algorithm for calculating budget losses from the provision of tax reliefs. In view of the above, the purpose of the article is to determine methodological approaches to the formation of Directories and, accordingly, Reports of the State Tax Service of Ukraine on tax reliefs (on the example of VAT reliefs), that are losses of budget revenues, and on other tax reliefs and justification of the guidelines for improving the quality of such reports. Based on the analysis of concepts of benchmark tax system (tax) and tax expenditure and approaches to determining their main elements, the author formulates requirements for the structure of Directories of tax reliefs and Reports on tax reliefs, in particular, it is established that if the Directory of tax reliefs, which are losses of budget revenues should include only tax expenditures, then in the structure of the Directory of other tax incentives two components can be distinguished – "structural incentives", which are elements of the benchmark tax system, and special incentives that do not lead to the loss of budgetary revenues. In order to facilitate the identification and analysis, the main components of "structural VAT reliefs" in Ukraine, as well as types (groups) of reliefs that do not cause budget losses are identified, cases of unjustified classification of tax reliefs in the State Tax Service Directories are considered and proposals to change their classification are substantiated. Based on the calculations, it was identified which groups of reliefs predominate in the system of other reliefs, as well as in the reliefs that are losses of budget revenues. According to the results of the study, it was concluded that the amount of "structural reliefs" of VAT in Ukraine is 4.5 times higher than the amount of tax expenditures, which, if necessary, can be considered as a reserve for increasing tax revenues to the state budget of Ukraine. The shortcomings of the systematic accounting of VAT reliefs in the Directories of tax reliefs have been identified and proposals aimed at improving the correctness and completeness of their accounting have been developed.
The influence of government debt policy on the development of Ukraine's economy
Authors:   State Institution “Institute for Economics and Forecasting, NAS of Ukraine”, Harkavenko Valentyna , Yershova Galina ,   State Institution "Kundiiev Institute of Occupational Health of the National Academy of Medical Sciences of Ukraine"
Published: September 2022

The influence of the government's debt policy on the development of Ukraine's economy is analyzed. It is determined that today almost all indicators of debt stability in Ukraine exceed the critical limit, beyond which the state loses the ability to solve debt problems on its own. Thus, during 2014–2021, the domestic public and state-guaranteed debt of Ukraine increased in hryvnia equivalent by 3.9 times and as of the end of 2021 amounted to UAH 1,111.6 billion. The increase in debt was primarily due to direct public debt, which increased 4.1 times during the analyzed period. It is concluded that the scale of government borrowing in Ukraine makes it a threat to the economy, because without a change in the current government debt policy, the risk of the government's inability to meet its obligations to repay and service the debt will increase. Emphasis is placed on rethinking the country's economic policy in the direction of limiting the country's debt dependence, improving the structure of balance of payments and foreign trade balances, a balanced approach to the liberalization of relations in the foreign economic sphere and attracting foreign investment. A detailed analysis of trends in the issuance of domestic and external government bonds, as well as attracting debt financing from international financial organizations. The study of trends, and most importantly the structure of domestic government bonds, suggests that their growth is due to the need to finance not only the state budget deficit, but also the shortcomings and miscalculations of monetary and debt policy, as well as protectionist interests of individual businesses. Emphasis is placed on the fact that a significant share of non-residents' funds in domestic government bonds increases the country's exchange rate and financial vulnerability and is a factor that allows non-residents to influence the foreign exchange market and, accordingly, the national currency and international reserves of Ukraine.
Peculiarities of non-financial reporting development in Ukraine
Authors:   National University of Life and Environmental Sciences of Ukraine, Dielini Maryna
Published: September 2022

Under the condition of sustainable development, corporate social responsibility (CSR) becomes more important, and can be the key to improving the company's image and competitiveness on the market. Areas and forms of CSR implementation are numerous, one of which is the company's reporting on socially responsible practices. The importance of non-financial reporting is also emphasized by the Concept of state policy in the field of promoting corporate social responsibility in Ukraine until 2030 that highlights the necessity to publish non-financial reporting, which substantiates the topic of this scientific article. The purpose of the article is to determine the features of the introduction and dissemination of the practice of compiling and forms of non-financial reporting in Ukraine as a direction of manifestation of social responsibility of business. Methods of the article include analytical, statistical, comparison, and extrapolation ones etc. Theoretical analysis allows determining the main standards by which non-financial reports can be generated. These include: Global Reporting Initiative (GRI), UN Global Compact Report, AA1000 Standard, SA 8000: 2001 Social Responsibility Standard, and ISO 26000 Standard. Among the most common are the GRI Standard and UN Global Compact Report. The practical results of the study reveal that in Ukraine the number of GRI reports has increased compared to 2008, but this development is uneven. A comparison of the number of non-financial reports in Ukraine and Europe according to the Corporate Register found out that the number of reports in European countries has different trends: a decrease in 2017-2018 in some countries (UK, Germany, and France) and a subsequent revival to gradual growth in all countries. Analysis of the Transparency Index, calculated by the Center for the Development of Corporate Social Responsibility that considers the websites of companies based on CSR information for the period 2012-2020 reflects a change of countries that are leaders in this indicator. A positive characteristic is that among the TOP-10 companies there are not only private enterprises, but also state-owned ones. Overall indicators of CSR practices tend to increase and reflect the growing importance of this area of corporate social responsibility.
STIMULATION OF THE PROTEINASEPROTEINASE INHIBITOR SYSTEM AS A RESULT OF IMMERSION HYPOTHERMIA [
Authors:   GI “L.T. Malaya Therapy National Institute of the National Academy of Medical Sciences of Ukraine”, Kharkіv, Ukraine, Samokhina L.M. , Lomako V.V. ,   Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of Ukraine, Kharkіv, Ukraine
Published: September 2022

The effect of immersion hypothermia (IН) on proteolysis activity in adult male rats, which was performed at 0 °C for 5 min in the “forced swimming” test, studied; the body temperature decreased to 27.5 ± 0.5°C. In blood serum and non-nuclear fractions of homogenates of cerebral cortex, hypothalamus, cerebellum, brainstem, lungs, heart, liver and kidneys tissues were determined the total proteinase activity (TPA), non-trypsin-like proteinases (NTPs), such as chymase, prostate-specific antigen, partially tonin, kallikrein rK9, as well as trypsin-inhibitory activity of α-1-proteinase inhibitor (α-1-PI), α-2-macroglobulin (α-2-MG) by highly sensitive (10-9–10-10 g) enzymatic methods. It is noted that IH led to the TPA increase in all studied tissues (4-84 times), which corresponds to the psycho-emotional effects and the phenomenon of hormesis. After 24 h, TPA decreased, remaining above the control level, and in the kidneys increased further (90 times). NTLP activity as a result of IH increased in blood serum and cerebellum, decreased in the hypothalamus, and after 24 h increased further in serum (7 times), cerebellum, and heart. The activity of α-1-PI also increased in the brainstem, lungs, heart and kidneys, and decreased after 24 h in serum below the control level, and in the brainstem remained high, protecting against proteolytic attack. The activity of α-2-MG increased in the hypothalamus, heart, and cerebral cortex, maximum in the brainstem (2-5 times), and after 24 h - more significantly (24 times), but there were no changes in the cerebellum, where its initial level is the biggest. Thus, the development of IG as a result of swimming in cold water for 5 min at 0oC has a stimulating effect on the body and leads to a significant activation of the reactions of limited proteolysis.
NEUTROPHIL EXTRACELLULAR TRAPS IN ACUTE PANCREATITIS
Authors:   Lviv Regional Clinical Hospital, Ukraine, Chooklin S. , Chuklin S. ,   St. Paraskeva Medical Center, Lviv, Ukraine, Barylyak R. ,   Lviv Regional Clinical Hospital, Ukraine
Published: September 2022

The review focuses on the role of neutrophilic extracellular traps (NETs) in the pathogenesis of acute pancreatitis. It is shown that NETs can activate trypsin, cause inflammation and pancreatic tissue damage, and clog the excretory ducts. NETs are involved in the formation of gallstones, which are one of the leading etiological factors of acute pancreatitis. NETs also surround necrotic tissue in patients with severe acute pancreatitis and contribute to further systemic inflammatory response syndrome. The mechanisms of NETs formation in acute pancreatitis, in particular, the importance of damageassociated molecular patterns, neutrophil microparticles, and platelets in these processes are considered.
Potencial nematicida de hongos aislados de cultivos de plátano dominico hartón (Musa AAB Simmonds) del suroeste antioqueño
Authors: Marin Pavas Duber Alexander , Alzate-Tamayo Juan Pablo , Calle-Restrepo Alejandro , Salazar-Moncada Diego Alberto , Ocampo-Jiménez Omar , Calle-Osorno Jaime de Jesús
Published: September 2022

El objetivo de este trabajo fue evaluar el potencial nematicida de aislados fúngicos provenientes de cultivos de plátano de los municipios de Andes y Jardín (Suroeste antioqueño). Se analizaron in vitro diez aislados fúngicos frente a los nematodos fitoparásitos de los géneros Meloidogyne y Radopholus. Los hongos pertenecían a los géneros Paecilomyces, Pochonia, Arthrobotrys, Lecanicillium y Metarhizium. Se realizaron pruebas metabólicas cualitativas con diversos sustratos con el fin de observar la capacidad de degradación de diferentes compuestos característicos en la estructura de huevos o juveniles de nematodos. También, se evaluó la capacidad de colonizar huevos o juveniles de Meloidogyne sp. y, la mortalidad de los aislados frente a los géneros Meloidogyne y Radopholus. Se encontró que la mayoría de los aislados fueron capaces de degradar Tween 80 (90% de los aislados), seguido de caseína (80%), gelatina (80%), Tween 20 (60%), y en menor medida quitina (40% de los aislados); además, el 30% de los aislados presentaron formación de cristales en los medios de Tween. El 70% de los aislados podían infectar huevos, mientras que el 30% restante infectaban juveniles (J2) de Meloidogyne sp., después 24 horas de incubación. En cuanto al porcentaje de mortalidad del hongo y el filtrado, se encontró que todos los aislados difieren del control (p<0.05), siendo aislados de los géneros Pochonia y Paecilomyces quienes presentaron porcentajes de mortalidad superiores al 90%.
Autoeficácia e procrastinação acadêmica em estudantes do ensino superior
Authors: Fior Camila Alves , Sampaio Rita Karina Nobre , Reis Cláudia Angélica do Carmo , Polydoro Soely Aparecida Jorge
Published: September 2022

Os objetivos do estudo são analisar as diferenças da autoeficácia na formação superior (AEFS) e da procrastinação acadêmica em função do sexo, idade e momento do curso e estabelecer relações entre os construtos. Participaram da investigação 1.635 estudantes do ensino superior, 66,5% mulheres, 48,6% ingressantes e 67,5% menores de 22 anos. Os instrumentos utilizados foram a Escala de Autoeficácia na Formação Superior e a Escala de Procrastinação Acadêmica. As mulheres relataram níveis superiores na AEFS e nas dimensões regulação da formação, ações proativas e gestão acadêmica. Os estudantes mais velhos descreveram autoeficácia mais elevada na totalidade da escala e em todas as dimensões e os ingressantes indicaram menor nível de autoeficácia acadêmica. Os homens e os estudantes mais jovens relataram resultados mais elevados na procrastinação. As correlações entre a autoeficácia e a procrastinação são negativas e, na maioria, moderadas. Os achados reforçam a relação conceitual entre os construtos e potenciais implicações para o sucesso acadêmico são discutidas.
POLITIK HUKUM PERKAWINAN BEDA AGAMA DI INDONESIA (Analisis Mengenai Intervensi Partai Politik terhadap Undang-undang Nomor 1 Tahun 1974 Tentang Perkawinan)
Authors: Abdurrahman Hakim
Published: September 2022

This paper aims to analyze the existence of political party intervention in legislative drafting on regulation No 1/1974 about marriage. Political party intervention is actually contrary to responsive legal theory that is applied in the formation of regulations in Indonesia. Political party intervention can change the legal content in the formulation of legislation because there are interests that are subjective. The implication, of course the resulting legal products will not solve problems in society that have been assessed as public issues. If examined from the perspective of public policy, Government intervention is likely to occur at the policy planning stage. This is due to the process, the party as an element of political power views the importance of the values ??of flow in order to be contained in the laws discussed. The result, the regulations that have been passed are far different from the proposed bills. One example is the Marriage regulation. Debate and rejection occur in the discussion of the article 2 (1) UUP 1974. The affiliation of Islamic parties considers marriage to be a matter of worship and religious values. On the other, Nationalist party affiliation refused because it did not reflect reception legal theory.
Pelayanan Publik Pada Dinas Kependudukan dan Pencatatan Sipil di Kabupaten Lamongan Dalam Perspektif Fikih Siyasah
Authors: Musyafaah Nur Lailatul , Wijaya Arif
Published: September 2022

This article discusses public services at the Population and Civil Registration Service (Dispendukcapil) Lamongan according to Fiqh Siyasah. This research is field research and is qualitative in nature. Data were collected through observation, interviews, and documentation. The collected data were analyzed by the deductive method. The result of the research shows that public services in the Dispendukcapil Lamongan are related to administrative services, which include population services (KTP, KK, Transfer Certificate) and civil registration services (birth certificates, death certificates, marriage certificates, divorce certificates, child validation certificates). Even though the Dispendukcapil Lamongan has made efforts to improve services, there are still complaints from the public in several services, both from service attitudes and facilities, including in the queuing system and waiting room facilities. In the fiqh siyasah perspective, the public services provided by the Dispendukcapil Lamongan are part of the fiqh siyasah idariyyah (administrative management fiqh). In serving the people, a state employee must be trustworthy, honest, and fair. The service must be based on benefit as the rule of tasharruf al-imam ala al-raiyyah manut bi al mashlahah (Public service must be based on maslahat). Based on this, it is hoped that the Dispendukcapil Lamongan will further improve the quality of services, facilities, and infrastructure.

 

Abstrak: Artikel ini membahas tentang Pelayanan Publik pada Dinas Kependudukan dan Pencatatan Sipil (Dispendukcapil) Lamongan menurut Fikih Siyasah. Penelitian ini adalah Penelitian lapangan dan bersifat kualitatif. Data dikumpulkan melalui observasi, wawancara dan dokumentasi. Data yang terkumpul dianalisis dengan metode deduktif. Hasil penelitian adalah pelayanan publik di Dispendukcapil Lamongan adalah berkaitan dengan pelayanan administrasi yaitu meliputi pelayanan kependudukan (KTP, KK, Surat Keterangan Pindah) dan pelayanan pencatatan sipil (Akta Kelahiran, Akta Kematian, Akta Perkawinan, Akta Perceraian, Akta pengesahan anak). Meskipun Dispendukcapil Kabupaten Lamongan telah berusaha meningkatkan pelayanan, masih terdapat keluhan masyarakat dalam beberapa pelayanan baik dari sikap pelayanan maupun fasilitas, di antaranya dalam sistem antrian dan fasilitas ruang tunggu. Dalam perspektif fikih siyasah, pelayanan publik yang diberikan Dispendukcapil Kabupaten Lamongan merupakan bagian dari fikih siyasah idariyyah (fikih pengelolaan administrasi). Dalam melayani rakyat, seorang pegawai negara harus amanah, jujur dan adil. Pelayanan tersebut harus didasarkan pada kemaslahatan sebagaimana kaidah tasharruf al-imam ala al-raiyyah manut bi al mashlahah (Pelayanan publik harus didasarkan pada maslahat). Berdasarkan hal tersebut, diharapkan DIspendukcapil Lamongan semakin meningkatkan kualitas pelayanan, sarana dan prasarana.
Altruistic Hedonic Games
Authors: Kerkmann Anna Maria , Nguyen Nhan-Tam , Rey Anja , Rey Lisa , Rothe Jörg , Schend Lena , Wiechers Alessandra
Published: September 2022

Hedonic games are coalition formation games in which players have preferences over the coalitions they can join. For a long time, all models of representing hedonic games were based upon selfish players only. Among the known ways of representing hedonic games compactly, we focus on friend-oriented hedonic games and propose a novel model for them that takes into account not only the players’ own preferences but also their friends’ preferences. Depending on the order in which players look at their own or their friends’ preferences, we distinguish three degrees of altruism: selfish-first, equal-treatment, and altruistic-treatment preferences. We study both the axiomatic properties of these games and the computational complexity of problems related to various common stability concepts.
Will Innovation management and re-engineering positively affect sustainability and performance? Research in energy companies
Authors: Sonmez Cakir Fatma , Adiguzel Zafer
Published: September 2022

Failure in reengineering or innovation management will not only decrease the performance of the organization but also endanger its sustainability. Objective. To carry out a study on energy companies to investigate the importance of the subject. Methodology. The reason energy companies are selected for the research is that innovation and change come to the fore with the need for new energy sources. LISREL, SPSS 25 and SPSS PROCESS V.3 were used in the analyses. Results. As a result of the research, it can be said that innovation management in energy companies has a positive impact on both sustainability and performance. At the same time, both the independent and the mediation variable effect of reengineering is positive. Conclusions. Innovation and change are inevitable and can be explained as a result of research where positive results can be achieved if properly managed.