bluuebunny/crossref_metadata_2025 huggingface dataset:
Implementasi Sistem Penilaian Kurikulum 2013 pada Mata Pelajaran Matematika
Authors: Ahmad Nurul Qomariyah , Harahap Rosliana , Amalia Anisa
Published: October 2023

Sistem penilaian perlu disesuaikan dengan perkembangan dan kebutuhan dalam rangka pengendalian mutu pendidikan. Penelitian ini bertujuan untuk mengetahui implementasi sistem penilaian kurikulum pada mata pelajaran matematika kelas VII di MTsN 1 Takengon dan kendalanya. Menggunakan metode kualitatif deskriptif dengan instrumen pedoman wawancara, observasi dan dokumentasi. Keabsahan data dengan triangulasi teknik dan analisis data berdasarkan teori Miles dan Huberman. Berdasarkan hasil penelitian guru telah menerapkan prinsip penilaian, mekanisme penilaian yang meliputi pembuatan kriteria ketuntasan minimal (KKM) dan adanya rencana penilaian yang ditulis dalam rencana pelaksanaan pembelajaran. Selain itu guru melakukan penilaian sikap, pengetahuan dan keterampilan dengan bentuk penilaian meliputi penilaian harian, penilaian diri, ulangan, penilaian tengah semester (PTS) , penilaian akhir semester (PAS) yang akhirnya diolah menjadi nilai raport. Sedangkan kendala yang dihadapi guru perlu belajar mengkonversi nilai dalam mengolah nilai raport.
Eksistensi Harta Bersama Dari Perkawinan Campuran
Authors: Anwar Anwar MS
Published: October 2023

Harta yang diperoleh dalam perkawinan adalah harta yang diperoleh selama perkawinan. Namun keberadaan harta bersama tersebut merupakan percampuran antara perolehan istri dan suami dalam perkawinan yang sah menurut syariat dan hukum yang berlaku. Harta bersama dari perolehan istri dan suami akan membawa manfaat jika keluarga dibina. Harta bersama akan berakhir pada saat kedua belah pihak berpisah, baik karena perceraian atau kematian.
Atividade física e longevidade
Authors: Kitayama Caroline
Published: October 2023

O envelhecimento está relacionado a várias alterações orgânicas de um corpo. Há limitações físicas, com redução de habilidades, alteração de percepções, mudança nos reflexos. Os recursos medicamentosos têm como objetivo melhorar o funcionamento fisiológico do corpo, aumentando, ou oferecendo melhores condições para a manutenção de determinadas funções. No entanto, é importante observar as necessidades de independência e de autonomia dessa população. Entre as ações que devem ser aliadas a uma melhor adaptação a essa nova etapa da vida, a atividade física deve ser tratada como recurso indispensável para um envelhecimento ativo. Este estudo apresenta uma revisão da literatura ressaltando os apectos neuroanatomicos, neuro-humorais e a atividade física como regulador hormonal.
Resistance training and hematological responses
Authors: Câmara de Almeida Daniel , Lacerda Oliveira Rios Wellington , Janssen Gomes da Cruz Carlos , Montecelli Eduardo , Sebastião Emerson , Sousa da Silva Renato André
Published: October 2023

Aplastic anemia is a hematopoietic dysfunction that compromises pluripotent cells; the phenomenon that gives rise to the multiplication and maturation of the precursor or primordial cells of blood cells. It is commonly treated with immunosuppressive therapy and/or halogenic bone marrow transplantation. However, despite the comorbidities of aplastic anemia, studies associating physiological changes related to regular physical exercise are still scarce, possibly due to the low prevalence of the disease. Thus, we describe here the impact of a resistance training program on different hematological markers in a patient with severe aplastic anemia. A 39-year-old white male diagnosed with aplastic anemia 22 years ago underwent 12 weeks of resistance training. Different hematological markers were analyzed before and after 7 and 12 weeks of intervention. After the intervention an increase in reticulocytes and several other blood components were observed, the values of which remained within normal limits. In addition, there was a reduction in transaminases and liver enzymes that mark canalicular lesions, proving an improved liver condition. We conclude that after 12 weeks of strength training the patient presented positive changes in different hematological markers, such as erythrocytes, hemoglobin, hematocrit, neutrophils, and leukocytes, suggesting a positive effect of resistance training on the patient's clinical picture associated with the natural course of disease treatment.
Editorial
Authors: Valenzuela Muñoz Alberto
Published: October 2023

La Revista de Investigación Científica Huamachuco, publicada semestralmente por la Universidad Nacional Ciro Alegría (UNCA), tiene como objetivo difundir contribuciones originales e inéditas de autores nacionales e internacionales que resultan de investigaciones científicas y tecnológicas.
Esta revista está dirigida a investigadores, estudiantes, académicos y profesionales con competencia e intereses en las ciencias sociales y aplicadas, adoptando un enfoque multidisciplinario. Los hallazgos presentados en la revista aportan relevancia e impacto tanto para la comunidad científica como para el sector empresarial y la sociedad en general.
Economic valuation for the conservation of the Huallaga River by the population of Tingo María, Las Orquídeas – Naranjillo de Leoncio Prado section
Authors: Oré Cierto Luis Eduardo , Quispe Trinidad Miguel Ángel , Loarte Aliaga Wendy Caroline
Published: October 2023

The objective of the research work was to estimate the economic valuation for the conservation and/or protection of the Las Orquideas to Naranjillo section of the Huallaga River on behalf of the population in Tingo Maria, [Peru], and the nearby areas. In order to estimate the willingness to pay (WTP; DAP in Spanish), a survey was done [with a] questionnaire, organized according to the contingent valuation method. For the statistical analysis, the probabilistic, logistic, and multiple linear regression econometric models were used. According to the results of the analysis, it was concluded that the demand curve of the probabilistic model was: WTP-P = 1.097*X7 + 0.762*X12 + 0.443*X13 – 0.219*X16 – 0.582*X17; [for the] logistic model, it was: WTP-L = 1.811*X7 + 1.313*X12 + 0.778*X13 – 0.374*X16 – 0.999*X17; and [for the] multiple linear regression model, it was: WTP-RLM = 0.494 + 0.051*X1 + 0.267*X7 + 0.194*X12 + 0.109*X13 – 0.062*X16 – 0.169*X17; where X1: type of home, X7: assessment of the Huallaga River, X12: intervention [in the] conservation of the Huallaga River, X13: level of education, X16: price they were willing to pay, and the WTP. The average willingness to pay predicted at 84.54% [accuracy]. For the probabilistic model, the average WTP was 6.87 soles, with a variation of 52.97%; [for] the logistic model, the average WTP was 6.84 soles, with a variation of 52.60%; and [for] the multiple linear regression model, the average WTP was 14.92 soles, with a variation of 23.10%.
Technologies for automation of online learning and teaching, adaptation of content and personalization of the learning process
Authors: Gutierrez Sullca Erika Mirella
Published: October 2023

Education is fundamental in the development of every human being; However, the evolution of technology combined with education gave rise to online education. The automation of learning in education provides beneficial benefits, one of the most significant tools is the incorporation of artificial intelligence, which allows the personalization of content tailored to users who use online learning platforms. In conclusion, the potential of learning automation in online education is promising; Continuous technological evolution foresees substantial improvements in the generation of personalized content.
Casos de éxito de Lean Manufacturing en PYMES: Una revisión de la literatura
Authors: Torres Morales Rosa Josselyn
Published: October 2023

La organización en el trabajo cobra cada mayor relevancia debido a la alta competitividad en el entorno empresarial, siendo necesario emplear herramientas o métodos que permitan a la organización obtener un valor agregado. El presente artículo de revisión de la literatura (ARL) se titula “Casos de éxito de Lean Manufacturing en PYMES: Una revisión de la literatura” en el que se plantearon objetivos como: identificar los casos de éxito de Lean Manufacturing en PYMES durante el periodo 2018 – 2023, seguido de los objetivos específicos: identificar las principales limitantes en la aplicación de Lean Manufacturing en PYMES durante el periodo 2018 – 2023 e identificar las herramientas más comunes en la aplicación de Lean Manufacturing en PYMES durante el periodo 2018 – 2023. Ante esto, los principales resultados indican que las empresas del sector PYME tienen múltiples casos de éxito donde evidencian incrementos significativos en la productividad, mejoras en sus tiempos y gestión de sus recursos, a pesar de presentar limitantes de aplicación tales como la falta de acceso a financiamiento, falta de compromiso por parte de la gerencia y empleados y la falta de adaptabilidad de todos los involucrados. Finalmente, la investigación concluye que las PYMES se ven ampliamente beneficiadas con la aplicación de las herramientas Lean Manufacturing y se puede constatar en los miles de casos de éxitos alrededor del mundo.
PLANNING MEDIA ADVERTISING OF JOB VACANCIES
Authors: Sančanin Branislav , Ratković Andrea
Published: October 2023

The primary task of media advertising planning is based on creating a measurable model that will ensure that an advertising message reaches the target group within the set deadlines and cost-effectively. Necessary activities are seen in the context of a dynamic and changing media environment, an increasingly demanding labor market, strong time pressures and insufficient information, with often unequal and inconsistent terminology. This paper examines the complex relationship between the content and context of media advertising and the positive reflections on the greater visibility of the advertising message and the activities undertaken by potential job candidates. The basic parameters on the basis of which media advertising is created, and after that the assessment of efficiency, are considered through quantitative and qualitative indicators for media planning.
MANIPULATIVNI ASPEKT MUZIKE
Authors: Tanasić Branislav R.
Published: October 2023

Svaki senzorni podražaj, bio vizuelni, audio ili neki drugi, generiše moždani odgovor u području korteksa gde se takve informacije primaju, obrađuju i daju puni smisao odnosno percepciju doživljenog. Moždana reakcija se može pratiti merenjem kortikalne aktivnosti kroz sinhronizovan odgovor većeg broja neurona, odnosno formirani elktrični talas. EEG skeniranja pokazuju da se talasi moždanog odgovora u alfa i beta opsegu sinhronizuju oko nosećeg ritma muzičke numere. Sinusoide moždanih talasa fazno se pomeraju tako da se vrh talasa uvek javlja u tačno određenom intervalu u tački koja prethodi narednom udarcu u ritmu bubnja. Na taj način ritam zapravo sinhronizuje moždane talase. Vekovima su ljudi koristili binauralne ritmove sa 4,5 udarca u sekundi, i tako izazivali razna mentalna stanja. Iako ne znajući za binauralne ritmove, za šamane je bilo nepogrešivo poznato da tako prouzrokuju šamanski trans, svirajući bubanj oko 4 do 7 udaraca u sekundi 13 do 15 minuta. Znali su da prepoznaju snagu i pozitivne učinke binauralnih podražaja. Ovaj rad je pokušaj da se rasvetle neke mogućnosti manipulativnih kapaciteta fenomena zvanog muzika.
KOMPETENCIJE BANKARSKIH MENADŽERA U KONTEKSTU GLOBALIZACIJE
Authors: Poštin Jasmina , Jagodić Rusić Aleksandra , Sančanin Branislav
Published: October 2023

Danas se banke, kao najvažnije finansijske institucije u svetu, suočavaju sa ozbiiljnim izazovima i globalnim pitanjima izazvanih finansijskim krizama i društvenim, ekonomskim i političkim promenama. Način upravljanja bankama koje su suočene sa ovim izazovima postaje ključno za njihov uspon ili pad, posebno imajući u obzir žestoku konkurentsku bankarsku industriju. Glavnu ulogu u ovom “modernom bankarstvu” zauzimaju kvalifikovani menadžeri. Na njima je da pronađu rešenja kako bi opstali konkurentni na globalnom nivou, zatim da su orijentisani na klijente i kontinuirana poboljšanja, kao i da su usmereni ka novim tehnologijama. Problem istraživanja predstavljaju promenljive kompetencije menadžera u procesu globalizacije. Osnovni cilj je da se ispitaju opšte kompetencije menadžera kako bi se došlo do nalaza ključnih kompetencija neophodnih za modernu bankarsku upravljačku strukturu. U ovoj studiji istraživanje će biti bazirano na analizi postojeće literature, sa akcentom na novija istraživanja. Rezultati su korisni za osnaživanje bankarskih menadžera na osnovu najpotrebnijih veština.
DAVČNE UTAJE V SLOVENIJI
Authors: Longar Urška , Grivec Malči
Published: October 2023

Davki so finančna obremenitev davkoplačevalcev, torej fizične ali pravne osebe. Z odvajanjem davkov se na eni strani zmanjšuje razpoložljiv dohodek zavezanca, na drugi strani pa le-ti predstavljajo prihodek davčne blagajne. Ta sredstva so temelj delovanja države, saj so namenjana financiranju javnih storitev. Četudi imamo tako od tega korist državljani, pa se pogosto zgodi, da se posamezniki plačilu davkov izogibajo oz. da prihaja do davčnih utaj. Do davčne utaje pride, ko fizična ali pravna oseba prikrije podatke o poslovanju z namenom, da bi plačala manjšo dajatev oziroma ko te dajatve sploh ne želi plačati. Pri tem ima pomembno vlogo davčni urad, saj lahko le v dobro razvitem davčnem sistemu država zagotovi, da bo prejela planirane prihodke iz naslova davkov. Kljub nadzoru nad plačanimi davki pa prihaja do razlike med načrtovanim in dejansko prejetim denarjem ‒ to razliko imenujemo davčna vrzel. Ta pa nastane zaradi izogibanja plačevanju davkov, davčnih utaj, nezmožnosti plačila zapadlih obveznosti ter postopkov zaradi insolventnosti. V empiričnem delu prispevka predstavimo podatke o davčnih utajah v Sloveniji. Prikažemo gibanje davčne vrzeli in neizterjanega DDV v letih od 2012 do 2018. Na podlagi tega ugotovimo, ali se davčna vrzel skozi preučevana leta zmanjšuje ali povečuje ter kakšni so razlogi za ugotovljene trende.
ZADUŽENOST I ODRŽIVI RAZVOJ
Authors: Piljić Jozo
Published: October 2023

Udjel javnog duga Bosne i Hercegovine u bruto domaćem proizvodu (BDP) u 2020. godini iznosio je 35,08 posto. Unutarnji dug se uglavnom sastoji od stare devizne štednje, ratnih potraživanja i dugova nižih razina vlasti. Slab kreditni rejting zemlje je u velikoj mjeri ograničio prije svega vanjsko, ali i unutarnje javno zaduživanje u poslijeratnom periodu. Premda je relativna visina državnog duga (35,08%), znatno ispod gornje granice od 60% BDP-a koju propisuje Europska unija, ipak s državnim dugom treba upravljati iznimno oprezno jer prekomjerno zaduživanje, zaduživanje radi financiranja državnog proračuna odnosno (osobne) potrošnje, jedan je od glavnih faktora unutarnje neravnoteže. Javna zaduženost Bosne i Hercegovine je na kraju 2020. godine iznosila 12,15 milijardi KM, od čega je vanjski dug 8,66 milijardi KM ili 71,27 posto, a unutrašnji dug 3,49 milijardi KM ili 28,73 posto. Najveći je nedostatak fiskalne politike u cjelokupnom razdoblju taj što se, unatoč prilivima odnosno prihodima od prodaje državne imovine (privatizacija), država zaduživala i nije uspjela stvoriti uvjete za brži ekonomski razvoj. S obzirom na to da banke u Bosni i Hercegovini u vlasništvu stranaca ostvaruju znatno više profite na ovom nego na inozemnom tržištu, da tome pridonosi i fiskalna politika, može se zaključiti da se radi o odlivu dohotka u inozemstvo.
INDUSTRIJA 5.0 I DIGITALNO POSLOVANJE ORGANIZACIJA: UTICAJ NA LJUDSKE RESURSE
Authors: Lukić Nikolić Jelena
Published: October 2023

Tehnologija je svuda oko nas. Različita tehnološka rešenja su kroz istoriju pomagala savremenom čoveku da jednostavnije, brže i bezbednije obavi razne zadatke i aktivnosti. Svaka industrijska revolucija i njeni tehnološki izumi su dovodili do brojnih promena u načinu funkcionisanja organizacija. Doba pete industrijske revolucije (Industrije 5.0) je takođe uslovilo brojne promene u načinu poslovanja organizacija. U ovom radu je sagledan uticaj Industrije 5.0 na ljudske resurse – potpuna i delimična automatizacija radnih mesta, strah od gubitka posla, potreba za novim radnim pozicijama, novim znanjima i veštinama, ali i saradnja ljudi i robota.
Prediction of Electric Vehicle Energy Consumption in an Intelligent and Connected Environment
Authors: Liu Qingchao , Gao Fenxia , Zhao Jingya , Zhou Weiqi
Published: October 2023

Accurate energy consumption prediction is essential for improving the driving experience. In the urban road scenario, we discussed the influencing factors of energy consumption and divided the modes from various perspectives. The differences in energy consumption characteristics and distribution laws for electric vehicles using the IDM and CACC car-following models under different traffic flows are compared. An energy consumption prediction framework based on the LightGBM model is proposed. According to the study, driving range, acceleration, accelerating time, decelerating time and cruising time all significantly impact the overall energy consumption of electric vehicles. There are apparent differences in energy consumption characteristics and distribution laws under different traffic flows: average energy consumption is lower under low flow and increased under high flow. The CACC-electric vehicles consume more energy in low flow than IDM-electric vehicles. Under high flow, the opposite is true. The results show that the proposed framework has a high accuracy: the MAPE based on IDM datasets is 3.45% and the RMSE is 0.039 kWh; the MAPE based on CACC datasets is 5.57% and the RMSE is 0.042 kWh. The MAPE and RMSE are reduced by 33.7% and 50.6% (maximum extent) compared to the best comparison algorithm.
Além do paradigma: (sobre o legado de Thomas Kuhn)
Authors: Araújo Nabil
Published: October 2023

Adentra o denso debate em torno do polêmico A estrutura das revoluções científicas, de Thomas Kuhn, livro seminal que completou 60 anos em 2022 e é uma das mais citadas obras nas humanidades e nas ciências sociais, além de ter sido também favoravelmente recebido por cientistas naturais. Em busca de um olhar sobre o legado de Thomas Kuhn, o autor Nabil Araújo propõe uma releitura contemporânea do livro do célebre autor, em contraste com Os universos da crítica: paradigmas nos estudos literários, de Eduardo Prado Coelho, tendo ainda, como aporte, o texto escrito pelo renomado antropólogo Clifford Geertz sobre o autor de A estrutura das revoluções científicas.
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress
Authors: Wang Jinyang , Wen Yaxin , Zhao Wentao , Zhang Yan , Lin Furong , Ouyang Cong , Wang Huihui , Yao Lizheng , Ma Huanhuan , Zhuo Yue , Huang Huiying , Shi Xiulin , Feng Liubin , Lin Donghai , Jiang Bin , Li Qinxi
Published: October 2023

Accumulating evidence indicates that acetate is increased under energy stress conditions such as those that occur in diabetes mellitus and prolonged starvation. However, how and where acetate is produced and the nature of its biological significance are largely unknown. We observed overproduction of acetate to concentrations comparable to those of ketone bodies in patients and mice with diabetes or starvation. Mechanistically, ACOT12 and ACOT8 are dramatically upregulated in the liver to convert free fatty acid-derived acetyl-CoA to acetate and CoA. This conversion not only provides a large amount of acetate, which preferentially fuels the brain rather than muscle, but also recycles CoA, which is required for sustained fatty acid oxidation and ketogenesis. We suggest that acetate is an emerging novel ‘ketone body’ that may be used as a parameter to evaluate the progression of energy stress.
Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase
Authors: Boulet Manon , Gilbert Guerric , Renaud Yoan , Schmidt-Dengler Martina , Plantié Emilie , Bertrand Romane , Nan Xinsheng , Jurkowski Tomasz , Helm Mark , Vandel Laurence , Waltzer Lucas
Published: October 2023

N6-methyladenine (6mA) DNA modification has recently been described in metazoans, including in Drosophila, for which the erasure of this epigenetic mark has been ascribed to the ten-eleven translocation (TET) enzyme. Here, we re-evaluated 6mA presence and TET impact on the Drosophila genome. Using axenic or conventional breeding conditions, we found traces of 6mA by LC-MS/MS and no significant increase in 6mA levels in the absence of TET, suggesting that this modification is present at very low levels in the Drosophila genome but not regulated by TET. Consistent with this latter hypothesis, further molecular and genetic analyses showed that TET does not demethylate 6mA but acts essentially in an enzymatic-independent manner. Our results call for further caution concerning the role and regulation of 6mA DNA modification in metazoans and underline the importance of TET non-enzymatic activity for fly development.
Structural and biophysical analysis of a Haemophilus influenzae tripartite ATP-independent periplasmic (TRAP) transporter
Authors: Currie Michael J , Davies James S , Scalise Mariafrancesca , Gulati Ashutosh , Wright Joshua D , Newton-Vesty Michael C , Abeysekera Gayan S , Subramanian Ramaswamy , Wahlgren Weixiao Y , Friemann Rosmarie , Allison Jane R , Mace Peter D , Griffin Michael DW , Demeler Borries , Wakatsuki Soichi , Drew David , Indiveri Cesare , Dobson Renwick CJ , North Rachel A
Published: October 2023

Tripartite ATP-independent periplasmic (TRAP) transporters are secondary-active transporters that receive their substrates via a soluble-binding protein to move bioorganic acids across bacterial or archaeal cell membranes. Recent cryo-electron microscopy (cryo-EM) structures of TRAP transporters provide a broad framework to understand how they work, but the mechanistic details of transport are not yet defined. Here we report the cryo-EM structure of the Haemophilus influenzae N-acetylneuraminate TRAP transporter (HiSiaQM) at 2.99 Å resolution (extending to 2.2 Å at the core), revealing new features. The improved resolution (the previous HiSiaQM structure is 4.7 Å resolution) permits accurate assignment of two Na+ sites and the architecture of the substrate-binding site, consistent with mutagenic and functional data. Moreover, rather than a monomer, the HiSiaQM structure is a homodimer. We observe lipids at the dimer interface, as well as a lipid trapped within the fusion that links the SiaQ and SiaM subunits. We show that the affinity (KD) for the complex between the soluble HiSiaP protein and HiSiaQM is in the micromolar range and that a related SiaP can bind HiSiaQM. This work provides key data that enhances our understanding of the ‘elevator-with-an-operator’ mechanism of TRAP transporters.
STP4: spatio temporal path planning based on pedestrian trajectory prediction in dense crowds
Authors: Sato Yuta , Sasaki Yoko , Takemura Hiroshi
Published: October 2023

This article proposes a means of autonomous mobile robot navigation in dense crowds based on predicting pedestrians’ future trajectories. The method includes a pedestrian trajectory prediction for a running mobile robot and spatiotemporal path planning for when the path crosses with pedestrians. The predicted trajectories are converted into a time series of cost maps, and the robot achieves smooth navigation without dodging to the right or left in crowds; the path planner does not require a long-term prediction. The results of an evaluation implementing this method in a real robot in a science museum show that the trajectory prediction works. Moreover, the proposed planning’s arrival times is 26.4% faster than conventional 2D path planning’s arrival time in a simulation of navigation in a crowd of 50 people.
Improved deep learning image classification algorithm based on Swin Transformer V2
Authors: Wei Jiangshu , Chen Jinrong , Wang Yuchao , Luo Hao , Li Wujie
Published: October 2023

While convolutional operation effectively extracts local features, their limited receptive fields make it challenging to capture global dependencies. Transformer, on the other hand, excels at global modeling and effectively captures global dependencies. However, the self-attention mechanism used in Transformers lacks a local mechanism for information exchange within specific regions. This article attempts to leverage the strengths of both Transformers and convolutional neural networks (CNNs) to enhance the Swin Transformer V2 model. By incorporating both convolutional operation and self-attention mechanism, the enhanced model combines the local information-capturing capability of CNNs and the long-range dependency-capturing ability of Transformers. The improved model enhances the extraction of local information through the introduction of the Swin Transformer Stem, inverted residual feed-forward network, and Dual-Branch Downsampling structure. Subsequently, it models global dependencies using the improved self-attention mechanism. Additionally, downsampling is applied to the attention mechanism’s Q and K to reduce computational and memory overhead. Under identical training conditions, the proposed method significantly improves classification accuracy on multiple image classification datasets, showcasing more robust generalization capabilities.
TTC13 expression and STAT3 activation may form a positive feedback loop to promote ccRCC progression
Authors: Xie Lingling , Fang Yu , Chen Jianping , Meng Wei , Guan Yangbo , Gong Wenliang
Published: October 2023

Background

Renal cell carcinoma (RCC) originates from renal tubular epithelial cells and is mainly classified into three histological types, including clear cell renal cell carcinoma (ccRCC) which accounts for about 75% of all kidney cancers and is characterized by its strong invasiveness and poor prognosis. Hence, it is imperative to understand the mechanisms underlying the occurrence and progression of ccRCC to identify effective biomarkers for the early diagnosis and the prognosis prediction.

Methods

The mRNA level of TTC13 was quantified by RT-PCR, while the protein level was determined by western blot and immunohistochemistry (IHC) staining. Cell proliferation was measured by cck-8, and cell apoptosis was detected by flow cytometry. The binding of STAT3 to the promoter region of TTC13 was determined by the luciferase reporter assay and chip experiments. STAT3 nuclear translocation was assessed by immunofluorescence staining.

Results

We found that TTC13 was up-regulated in ccRCC, and TTC13 promoted cell proliferation as well as inhibited cell apoptosis and autophagy of ccRCC through wnt/β-catenin and IL6-JAK-STAT3 signaling pathways. Furthermore, TTC13 might play a role in the immune infiltration and immunotherapy of ccRCC. Mechanistically, STAT3 activated the transcription of TTC13 gene.

Conclusions

STAT3 directly regulated TTC13 expression through a positive feedback loop mechanism to promote ccRCC cell proliferation as well as reduce cell apoptosis and autophagy. These findings suggested new and effective therapeutic targets for more accurate and personalized treatment strategies.
Stress, Anxiety, and Depression among Nursing Students at a Tertiary Teaching Hospital in Karnataka, India: A Cross-sectional Study
Authors: Nair Rachana K , Ahmed Mansoor
Published: October 2023

Introduction: Nursing students are valuable human resources in the health profession. During their student life, they face a great deal of stress, which can negatively affect their mental and physical health, as well as their academic performance. However, there is limited evidence regarding stress, anxiety, and depression among nursing students in Karnataka, India. Aim: To estimate the prevalence of stress, anxiety, and depression among nursing students and determine the factors associated with these conditions amongst them. Materials and Methods: A cross-sectional study was conducted at Department of Community Medicine, Mysore Medical College and Research Institute, Mysuru from March 2022 to August 2022, involving 200 undergraduate nursing students. The study included nursing students from the 1st year to the 4th year. Data was obtained using a predesigned and pretested questionnaire consisting of two parts: the first part collected details on sociodemographic and academic parameters, and the second part assessed psychological parameters using the Depression, Anxiety and Stress scale (DASS) 21 Scale. Data were entered into an excel spreadsheet and presented as frequencies and percentages using Statistical Package for Social Sciences (SPSS) software version 24.0. Factors associated with stress, anxiety, and depression were analysed using the Chi-square test, with a p-value <0.05 considered statistically significant. Results: A total of 200 nursing students participated in the study. The mean age of the participants was 20.22 years, with a standard deviation of 1.42. A total of 39 students (19.5%) reported moderate stress, while 26 (13%) reported severe to extremely severe stress. Approximately 35 (25%) participants experienced moderate to severe depression. Among the participants, 63 (31.5%) reported moderate anxiety, while 78 (39%) reported severe to extremely severe levels of anxiety. Factors such as academic year, lack of time for leisure activities, financial crisis in the family, and addiction to internet use were significantly associated with stress (p<0.05). Conclusion: The prevalence of depression, anxiety, and stress was high among nursing students in the study. These statistics can help nursing educators understand the challenges faced by nursing students and assist in promoting the quality of clinical practice.
Role of Serum β-hCG and First Trimester Ultrasonographic Parameters in Predicting Mid-trimester Pregnancy Outcomes: A Prospective Cohort Study
Authors: Rajamnickam Shanmuga Priya , Raveendran Sajeethakumari , Tripathy Saswati , Murugesan Anuradha , Panneerselvam Deboral
Published: October 2023

Introduction: One of the concerns in pregnant women is the risk of miscarriage and the psychological sequelae that follow. Screening in early pregnancy can identify future miscarriages in asymptomatic pregnancies. Aim: To study the role of serum Beta-Human Chorionic Gonadotropin (β-hCG) doubling and ultrasonic parameters like Yolk Sac Diameter (YSD), Gestational Sac Diameter (GSD), and Crown-Rump Length (CRL) in predicting mid-trimester pregnancy outcomes. Materials and Methods: A prospective cohort study was conducted at SRM Medical College and Hospital in Tamil Nadu, India, among 381 antenatal women between 6-10 weeks of gestation for a period of two years from December 2017 to July 2019. At baseline, parameters like serum β-hCG doubling titer at 48 hours and ultrasound parameters like YSD, GSD, and CRL were evaluated. The participants were followed-up until 20 weeks of gestation. The results were statistically analysed using sensitivity, specificity, Positive Predictive Value (PPV), and Negative Predictive Value (NPV). Results: The mean age of the women included in the study was 25.89±4.2 years, with the majority of women belonging to the 21-29 years age group. Among the enrolled pregnant women, 347 had normal outcomes while 34 experienced pregnancy failure. The results indicated that β-hCG was the strongest predictor of pregnancy outcomes with a sensitivity of 52.9%, specificity of 100%, PPV of 100%, and NPV of 95.6%. YSD predicted loss rates with a sensitivity of 50%, specificity of 97.1%, PPV of 62.9%, and NPV of 95.2%. GSD predicted miscarriage with a sensitivity of 17.6%, specificity of 97.4%, PPV of 40%, and NPV of 92.3%. CRL predicted miscarriage with a sensitivity of 30.5%, specificity of 97.9%, PPV of 61.1%, and NPV of 93.2%. Conclusion: β-hCG, YSD, GSD, and CRL were found to be statistically significant in predicting abnormal pregnancy outcomes. Among the four, β-hCG proved to be the best predictor.
Non-Surgical Treatment of Class II Division 1 Malocclusion in an Adult Patient with a Missing Lower Lateral Incisor Tooth: A Case Report
Authors: Wani Mohsin Aslam , Autar Ram , Siddiqui Shiraz , Amir Mohd , Trivedi Shashank
Published: October 2023

Class II Division 1 malocclusion is clinically more widespread than any other form of malocclusion and can be managed in a variety of ways, taking into account variables such as patient compliance, age, and anteroposterior disparity. Orthodontic camouflage treatment, aimed at masking the underlying skeletal discrepancy, is an acceptable option for most patients. This typically involves the extraction of two maxillary premolars in cases without mandibular arch crowding, or the extraction of two maxillary and two mandibular premolar teeth when crowding is present. The present case report aimed to discuss the successful treatment of a unique case involving a 19-year-old adult female patient with Class II Division 1 malocclusion, a missing mandibular left lateral incisor, and an overjet of 7 mm. Since the patient declined surgical and prosthetic treatment, an alternative, novel, and unorthodox method of camouflage treatment was employed, which involved the extraction of maxillary first premolars combined with symmetrical incisor space closure. The achieved treatment outcomes included a functionally and aesthetically acceptable occlusion, reduced overjet, and an improved soft tissue profile.
Double J Stent an Indispensable Device in Modern Urology Practice-Timely Removal Prevents Catastrophic Complications: A Retrospective Observational Study
Authors: Singh Harjinder , Singh Harbhupinder , Grewal Tejinderpal Kaur , Kaur Savleen , Sandhu Anoopinder Kaur
Published: October 2023

Introduction: Double J (DJ) stent placement is routinely used for various urological procedures. The potential complications of retained or forgotten stents include haematuria, infection, pain, ureteral injury, displacement, fragmentation, encrustation, stone formation, sepsis, renal failure, or even mortality. Various methods have been used alone or in combination for the retrieval of these encrusted stents. Their timely removal is crucial as the potential complications of retained or forgotten stents are very catastrophic and not cost-effective. Aim: To highlight the importance of timely removal/replacement of DJ stents. Materials and Methods: A retrospective observational study was conducted in the Department of Urology at Government Medical College, Patiala, Punjab, India, and data were collected from March 2021 to March 2023. A total of 149 patients who underwent DJ stenting for various procedures in the department or were referred from outside with attempted difficult removal were included in the study. Relevant investigations were performed. Data were collected from the registers maintained in the operation theatre. Data are presented as mean, numbers, and proportions as appropriate. Various procedures were used alone or in combination for stent removal. Results: The mean age of the study participants was 41.50 years with a range from 16 to 70 years. A total of 149 patients were included, and 163 procedures were performed to remove the DJ stents. A total of 24 (14.81%) stents patients developed complications in the form of mild encrustation of the renal and urinary bladder end of the stent, up migration, down migration, broken stents, heavy encrustations at both renal and bladder ends, partial intraperitoneal placement and stone formation at renal and bladder ends. Out of 163 total procedures,149 (91.41%) endoscopic retrievals were done, and 14 (8.59%) multiple procedures were done to remove stent fragments and stones. Postoperative complications were seen in 25 (16.78%) patients. Conclusion: Timely removal of DJ stents prevents catastrophic complications. The phrase by Desiderius Erasmus, “Prevention is better than cure,” holds merit in the present study
A Review on the Company Profile of TBM Seed Company and Its Sales and Marketing Policies
Authors: Thakur Deepak Kumar , Singh Anjali , Verma Tripti
Published: October 2023

Sales-Selling the products or services of a firm is referred to as sales. A crucial area for TBM in any seed company is sales and marketing. We must first comprehend sales and marketing in order to understand this. Marketing is the process of getting people to understand your goods through services, strategies, and advertising. Due to the difficulty and expense of marketing, strategic planning is required. This review Paper summarized all the key points and steps adopted by the company to accelerate the sales and marketing policies. This research is unique in that it offers proof of "how" MNCs are using a circular model. The marketing strategies of well-known companies are analyzed in-depth in this study in order to ascertain the aspects that have led to their market success.
Idiopathic Pulmonary Hemosiderosis in Pediatric in Patients: Report of Four Cases in Rabat, Morrocco
Authors: Benchidmi S.  , Lamghari Y.  , Saad A.  , Maalmi N.  , Jaabouti G.  , Aminou S.  , Elqoraichi O.  , EL Hafidi N.  , Mahraoui C.  , Benchekroun S.
Published: October 2023

Idiopathic pulmonary hemosiderosis (IPH) is a rare cause of diffuse alveolar hemorrhage. Patients with IPH usually present with the classical triad: hemoptysis, and iron deficiency anemia, and pulmonary infiltrates on chest imaging, the diagnosis is often delayed by years.

We report four IPH pediatrics cases of children diagnosed at the children’s hospital of Rabat, Morocco. The aim of this study is to review the clinical manifestations, diagnostic tools and treatment of this affection.

All the four patients were presented with the classical triad, the diagnosis was based on the Clinical, radiologic and biologic findings. Bronchoalveolar lavage was performed to all the patients and confirmed the diagnosis by the identification of siderophages.

High doses of Corticosteroids, by an induction therapy with an intravenous methylprednisolone (20 mg/kg/day for 3 days) followed by oral prednisone (1 mg/kg/day) had shown a good therapeutic response. One patient was treated first with oral corticosteroid and switched over to synthetic antimalarial drugs, because he had side effects from long-term cortico therapy. Then the clinical condition has been improved. The evaluation of response to the therapy included the clinical symptoms and signs, laboratory data and chest x ray. The prognosis of IPH is influenced by several factors, including the time of diagnosis, early initiation of treatment, and the presence of comorbidities.
Role of Sulphur Fertilization in Legume Crops: A Comprehensive Review
Authors: Dawar Rakesh , Karan Shyam , Bhardwaj Sunil , Meena Deepak Kumar , Padhan Smruti Ranjan , Reddy Kadapa Sreenivasa , Bana R. S.
Published: October 2023

Sulphur (S) is an indispensable macronutrient for plant growth and development, and its role in enhancing the productivity and quality of legume crops has garnered increased attention in agricultural research. This comprehensive review explores the multifaceted significance of sulphur fertilization in legumes, shedding light on the pivotal role it plays in optimizing crop performance. From its involvement in amino acid synthesis and protein formation to its impact on chlorophyll production and antioxidant defense mechanisms, sulphur is a key player in the intricate web of plant metabolic processes. The review delves into the intricate molecular mechanisms that underlie sulphur assimilation and its impact on various physiological functions in legumes. Additionally, it investigates the influence of sulphur on legume crop quality parameters, emphasizing its effect on protein content and amino acid profiles, as well as its role in improving crop resistance to abiotic and biotic stresses. The symbiotic relationships between legumes and nitrogen-fixing rhizobia further complicate the sulphur scenario, making it imperative to dissect the dynamic interplay between these crucial elements. With a backdrop of changing agricultural practices, environmental concerns, and the increasing demand for sustainable food production, this review addresses the challenges and opportunities in sulphur fertilization. It also highlights the need for precise nutrient management strategies to harness the full potential of sulphur in legume crop production. In conclusion, this comprehensive review serves as a valuable resource for researchers, agronomists, and policymakers, offering insights into the pivotal role of sulphur fertilization in enhancing the productivity, quality, and sustainability of legume crops in an ever-evolving agricultural landscape.
Molecular Modeling of Enoyl Acyl Carrier Protein Reductase Inhibitors for Mycobacterium tuberculosis and their Pharmacokinetic Predictions
Authors: Zonon Narcisse Fidèle , Mousse Logbo Mathias , Allangba Koffi N’Guessan Placide Gabin , Kouman Koffi Charles , Megnassan Eugene
Published: October 2023

Tuberculosis (TB) is a deep public health concern worldwide worsened by reported multi drugresistant (MDR) and extensively drug- resistant (XDR) stralins of Mycobacterium tuberculosis, the causative agent of the disease. A new class of thiadiazole inhibitors were reported to inhibit the enoyl-acyl transporter protein reductase (InhA) of Mycobacterium tuberculosis (MTb). We performed here the computer-aided molecular design of novel thiadiazole (TDZ) inhibitors of InhA by in situ modifying the reference crystal structure of (S)-1-(5-((1-(2,6-difluorobenzyl)-1 H-pyrazol-3yl)amino)-1,3,4-thiadiazol-2-yl)-1-(4-methylthiazol-2-yl)ethanol-InhA (PDB code: 4BQP). Thus a training set of 15 hybrids with known inhibition potency \(\left(\mathrm{IC}_{50}^{\exp }\right)\) was selected to establish a onedescriptor quantitative structure-activity relationship (QSAR) model resulting in a linear correlation between the Gibbs free energy (GFE) during the formation of the InhA-TDZ complex and \(\mathrm{IC}_{50}^{\mathrm{exp}}\left(\mathrm{plC} \mathrm{C}_{50} \exp ==-0.29 \mathrm{x} \Delta \Delta \mathrm{G}_{\mathrm{com}}+8.13 ; \mathrm{n}=15 ; \mathrm{R}^2=0.92, \mathrm{R}^2{ }_{\mathrm{xv}}=0.91 ;\right.\) F-test of \(142.6 ; \sigma=0.21 ; \alpha>\) \(\left.95 \% ; R^2-R_{x v}^2=0.01\right)\). The 3D pharmacophore model \((\mathrm{PH} 4)\) generated from the active conformations of TDZs ( \(\mathrm{pIC}_{50}^{\mathrm{exp}}=0.93 \times \mathrm{pIC}_{50}^{\text {pred }}+0.47 ; \mathrm{n}=15 ; \mathrm{R}^2=0.97 ; \mathrm{R}_{\mathrm{xv}}=0.94 ;\) F-test of \(215.45 ; \sigma=0.17 ; \alpha>98 \% ; R^2-R_{x v}^2=0.03\) ) served as a virtual screening tool for new analogs from a virtual library (VL). The combination of molecular modeling and \(\mathrm{PH} 4\) in silico screening of (\(\mathrm{VL}\)) resulted in the identification of novel potent antitubercular agent candidates with favorable pharmacokinetic profiles of which the six best hits predicted inhibitory potencies \(\mathrm{IC}_{50}^{\text {pre }}\) in the sub nanomolar range \((0.1-0.2 \mathrm{nM})\).
Knowledge Level of Farmers towards Use of Private Bio-fertilizers
Authors: Rakesh Karravula , Naik R. M.
Published: October 2023

Bio-fertilizers are ready-to-use live formulates of beneficial microorganisms that on application to seed, root or soil mobilize and augment the availability of nutrients through their biological activity in particular, and help build up microflora and soil health in general. The study was conducted in the Navsari district of South Gujarat using Ex-post facto research design. A total of 120 respondents were selected randomly. Private Bio-fertilizers in this study are referred to as the bio-fertilizers that are manufactured by private manufacturers. This study concluded that little less than half of respondents had moderate knowledge about use of private bio-fertilizers.The relationship between profile of the respondents and their knowledge level towards use of private bio-fertilizers revealed that Education, occupation, mass media exposure, scientific orientation were found positively and highly significantly associated at 1 per cent level of probability whereas, land holding, extension contact, social participation, risk orientation, economic motivation and management orientation were positively and significantly associated at 5 percent level of probability, while age, gender, family size, farming experience, annual income and family type had non-significant association with knowledge about use of private bio-fertilizers.
Elucidation of interface interactions between a dehydratase domain and an acyl carrier protein in cremimycin polyketide synthase
Authors: Kotagiri Kaede , Tachibana Haruka , Kawasaki Daisuke , Chisuga Taichi , Kashima Toma , Fushinobu Shinya , Kudo Fumitaka , Eguchi Tadashi , Miyanaga Akimasa
Published: January 2025

Modular polyketide synthases (PKSs) are multi‐domain enzymes involved in the biosynthesis of polyketide natural products. The dehydratase (DH) domain catalyzes the dehydration of the β‐hydroxyacyl unit attached to the acyl carrier protein (ACP) domain in modular PKS. Although the DH domain likely recognizes the cognate ACP domain during the dehydration reaction, the molecular basis of DH–ACP interactions remains elusive. In this study, we conducted cross‐linking analysis using a pantetheine‐type probe for investigating the ACP recognition of a fusion‐DH protein generated from a split‐DH domain of cremimycin PKS. Based on the AlphaFold 3‐predicted model structure of the fusion‐DH–ACP complex, DH–ACP interface residues were identified and validated by mutational analysis. Our findings provide the first detailed insights into domain–domain interactions between DH and ACP in modular PKSs.
Optimized Heat Treatment for Electron Beam Powder Bed Fusion Processed IN718: Correlating Microstructure, Texture, and Mechanical Properties
Authors: Vikram Raja Jothi , Kirchner Alexander , Klöden Burghardt , Suwas Satyam
Published: January 2025

This study investigates the microstructure and mechanical properties of Inconel 718 (IN718) manufactured via electron beam melting (EBM). The EBM‐processed IN718 exhibits a unique grain structure with columnar grains along the build direction (BD) and equiaxed grains perpendicular to it. Contrary to typical solidification textures, the strongest texture intensities are observed for (110) and (111) orientations, attributed to in situ δ phase precipitation during high‐temperature processing. The microstructure notably lacks cellular structures common in additively manufactured materials, instead featuring δ phase formed through in‐situ aging. A tailored heat treatment strategy is developed to control δ phase precipitation at grain boundaries, mitigating grain boundary sliding (GBS). This treatment results in <100> texture and large columnar grains, leading to a twofold increase in yield strength compared to the as‐printed (AP) condition. Interestingly, the AP EBM IN718 shows no signs of dynamic strain aging (DSA), distinguishing it from conventionally processed IN718. This comprehensive analysis of microstructure, texture, and mechanical behavior provides valuable insights for optimizing EBM processing and heat treatment of IN718 for enhanced performance in high‐temperature applications.