bluuebunny/crossref_metadata_2025 huggingface dataset:
Religiöser Universalismus im Zeitalter der Nation. Friedrich von Hügel und die deutsche Geisteswelt (Eucken, Troeltsch, Naumann)
Authors: Stoll Christian
Published: January 2022

The article analyzes the influence of German thought on Baron Friedrich von Hügel’s philosophy of religion. The activities of the British scholar in the networks of Catholic modernism are placed within the broader framework of the international discussion on religion around 1900. His religious universalism was shaped to a great extent by the encounter of German intellectuals from a liberal Protestant background, most notably by Rudolf Eucken, Ernst Troeltsch and Friedrich Naumann. This encounter, started during the 1890s, focussed on the concepts of historical individuality and historical development. It took a new direction with the public role adopted by German intellectuals in the propaganda of the World War. Von Hügel’s often ignored treatise The German Soul reacted to the fusion of liberal religious thought with German nationalism as observed in Troeltsch and Naumann. His criticism of a lack of „international morality“ of German thought and his approach to identify the reason for this deficit in the Lutheran and idealistic tradition shed light on the ongoing discussions of a „Sonderweg“ of German thought. Von Hügel’s late attempts to promote Christianity as an anti-nationalist force remind of other more theological rejections of nationalism after the war. However, these attempts are not based on a strict theological or confessional rationale (like in dialectical theology) but try to continue the interconfessional and interdisciplinary discussion of the beginning of the century. This is revealed best by von Hügel’s close but not uncritical relationship to Troeltsch in the early 1920s.
New methods for new needs? Analysis of the study plans in Social Work from the perspective of graduates: the case of the University of La Laguna
Authors:   Universidad Complutense de Madrid, Hernández-Melián Alejandro
Published: January 2022

The purpose of the research is to analyze the opinions of the graduates in Social Work of the University of La Laguna about their Study Plan, in order that it can serve to evaluate, improve and update this and other curricula of the discipline in other university centres. This work has a descriptive quantitative method and used a questionnaire for data collection, with 102 participants and statistical treatment with SPSS. The main results show a great demand to adjust, firstly, the teaching methods of the teaching staff to the new needs of their students, and secondly, the subjects and contents with the current social realities. Likewise, it points towards a disconnection between university-society, reflected in the problems derived from curricular practices and the application of workshops with external professionals and real practical cases as two of the favourites activities as content of practical classes. Therefore, studies in Social Work in Spain must remain in constant review so as not to be outdated, since social reality, its object of study and analysis, is an element in constant change.
Governance and public policies against rural depopulation through the case of La Rioja (Spain)
Authors:   Universidad de La Rioja, Andrés Sergio
Published: January 2022

Rural depopulation has become one of the central issues on the public agenda in the last decade in Spain. However, despite this visibility and the measures that are being developed, the process is still present. Within the policies against depopulation and rural development, the role of participation and empowerment of the affected populations has become particularly important. The objective is based on the fact that, through a more horizontal governance, they are the protagonists of the actions and measures that affect them, and that this governance becomes a means to avoid the depopulation of rural areas. The European Union's LEADER approach and the Local Action Groups have become the paradigm of this rural governance that favours their development and tackles depopulation. This article analyses the situation of rural governance in the case of a Spanish region such as La Rioja, which is affected by the depopulation of a large part of its rural areas. It starts with a theoretical framework that addresses the concept itself and how it is being articulated with issues such as social capital, territorial capital and participation, as well as the strengths and weaknesses of the scenarios that are being generated, based on the differences between territories. Next, the frameworks of depopulation in Spain are presented, which are marking the very public policies on the issue. Finally, the situation in La Rioja is addressed, focusing on the role of the regional government's plans and strategies to tackle depopulation and the role of the Local Action Groups.
LUIS DE ACOSTA, PLATERO, Y PEDRO ROLDÁN, ESCULTOR. SOBRE LA AMISTAD QUE LES UNIÓ Y EN RELACIÓN CON UN BELÉN QUE COMPARTIERON
Authors: Quiles García Fernando
Published: January 2022

Siguen unas líneas que nos ponen en antecedentes sobre la vida y obras de un platero que trabajó para la Catedral de Sevilla en la segunda mitad del XVII. No tuvo una obra destacada, pero sí una trayectoria que le vinculó con los más importantes artífices de la época, especialmente con Pedro Roldán, de quien llegó a tener un Nacimiento. Esto último nos permite situar a Roldán en un nuevo ámbito creativo, en el que su hija Luisa destacó, con lo que podríamos además establecer el vínculo entre maestro y discípula en ese nuevo escenario creativo.
A AMNESIA DE CLÍO, UNA ÓPERA GALLEGA EN EL PARADIGMA CONTEMPORÁNEO
Authors: Fernández Rosa María
Published: January 2022

Recién iniciado el siglo XXI, pocas artes plantean tantas preguntas a lo que significa el arte actual como la ópera, que despliega con toda su fuerza interrogativa aspectos tales como la apertura a la verdad de la obra de arte y el lugar del canon artístico en la obra actual. Este artículo se plantea el lugar que ocupa la ópera A amnesia de Clío del compositor gallego Fernando Buide en el paradigma artístico contemporáneo, a partir de un análisis contextual respecto a otras óperas del siglo XXI y desde una perspectiva hermenéutica que permita su valoración a partir de sus aportaciones a la experiencia estética contemporánea.
Recordando a la Sociedad Peruana de Salud Pública: 1950-1968
Authors: Bustíos Romaní Carlos M. , Pereyra Zaldívar Héctor
Published: January 2022

Se realiza una revisión crítica de la información disponible sobre la Sociedad Peruana de Salud Pública (SPSP), inaugurada como organización científica-gremial en agosto de 1950, y desactivada a fines de 1968 por un gobierno de facto. Con esta revisión, 53 años después de ocurrida esta desactivación, queremos mantener viva la memoria de sus esfuerzos para la unificación doctrinaria y la modernización técnica de la salud pública peruana en un contexto difícil; así como rendir homenaje póstumo a sus asociados, quienes nos enseñaron - con los hechos antes que con las palabras - cuál debe ser la conducta de un sanitaristaperuano.
Microcrédito formal y la sostenibilidad de las microempresas peruanas. Caso Lima
Authors: Mauricio Pachas Pablo Willins
Published: January 2022

Es de conocimiento público que Lima ha experimentado un fenómeno inmigratorio predominantemente desde la década de los 70’s, evidenciándose en una explosión demográfica desordenada, donde la población de menores recursos ha encontrado en el emprendimiento popular, opción para el auto empleo y mejorar sus ingresos económicos y acceder a mejor calidad de vida, creando microempresas. El microcrédito formal apareció como forma de apoyo mutuo, entre la entidad aportante y la receptora. Esta investigación de enfoque cuantitativo, tipo aplicado, nivel relacional, diseño no experimental y corte transversal buscó determinar la relación entre microcrédito formal y la sostenibilidad de las microempresas peruanas, en el caso Lima Metropolitana, 2020. Se obtuvieron resultados descriptivos, de dispersión, de normalidad, y de prueba de hipótesis. Los resultados finales permitieron determinar que el microcrédito formal se relaciona positiva y moderadamente con la sostenibilidad (general, ambiental, social y económica) de las microempresas peruanas, específicamente en Lima, 2020. Por último, se presentan recomendaciones a representantes y tomadores de decisiones del gobierno, a directivos de empresas del sector bancario y a investigadores del área especializada en esta temática.
Sabemos cómo impacta la selección y contratación de un talento humano para la organización?
Authors: Ipanaqué Feria Andreita del Carmen
Published: January 2022

Actualmente las organizaciones están pasando por cambios disruptivos, como la globalización de negocios, desarrollo tecnológico y desarrollo del talento humano que conllevan a generar mayor competitividad entre las organizaciones. Es así, que las empresas ante el fuerte impacto del cambio y el intenso movimiento de las organizaciones en busca de la calidad y productividad, se están enfocando en mejorar sus procesos de selección de personal por competencias para captar y seleccionar talentos humanos que agreguen valor, innovación y rentabilidad a la empresa. Por tanto, el objetivo del artículo, es relevar la importancia de los procesos de selección de competencias, y su impacto para la organización, la contratación de personal competente, revestido talento humano para el logro de ventajas competitivas únicas y sostenibles frente a la competencia. Es por eso, que, en los tiempos actuales, el modelo de selección por competencias tiene mayor relevancia en las competencias y habilidades que las empresas exigen a los profesionales, para que sean capaces de afrontar con éxito los retos del futuro, y así adaptarse a cambios internos y externos. Por el tipo de investigación, el presente estudio empleada es de tipo descriptivo, porque se basa en la descripción y/o narración de las características de un objeto observado; y de tipo Correlación, porque mide el grado de relación que existe entre dos o más variables.
Análisis Presupuestal de Gestión de Riesgos de Desastres en salud, Lima-Norte
Authors: Gonzales Guzmán Alberto
Published: January 2022

Determinar la relación de las metas presupuestales con las metas físicas del Programa presupuestal 068 “Reducción de la Vulnerabilidad y Atención de Emergencias por Desastres” de la Dirección de Redes Integradas de Salud Lima Norte (DIRIS Lima Norte), 2019. Metodología: Enfoque cuantitativo; la población estuvo conformada por todos los ítems mediante los cuales se dividió el presupuesto inicial modificado, a modo de una muestra censal. Se usó el método hipotético-deductivo y se aplicó la prueba de Wilcoxon. Resultados: Con un nivel de significancia de 5%, se obtuvo un p-valor > 0,05, por lo que, se afirma que en el análisis presupuestal no se encuentra una relación entre la ejecución de las metas presupuestadas y las metas físicas de la DIRIS Lima Norte, mediante lo cual puede establecerse dos situaciones: (a) baja ejecución presupuestal con alta ejecución de metas físicas; o (b) alta ejecución presupuestal con baja ejecución de metas físicas. Conclusiones: Las metas presupuestales no se relacionan con las metas físicas de la DIRIS Lima Norte.
Ingresos del canon y sobrecanon petrolero y sus efectos socioeconómicos. Estudio de casos en Perú
Authors: Chong Ríos Alexci Igor , Wong Valdiviezo Luis Ángel , Chong Ríos German Vladimir
Published: January 2022

El estudio identifica los efectos del ingreso por canon y sobrecanon petrolero (CSP) sobre dos aspectos socioeconómicos: Primero, su contribución al PBI y la productividad en la región Loreto. Segundo, encontrar la misma contribución del CSP en las regiones de Loreto, Piura, Tumbes, Huánuco y Ucayali en dos dimensiones: 1) la reducción de desigualdad, medida como el gasto per cápita entre el 40% más pobre de la población y, 2) el trabajo decente, medido sobre el porcentaje de jóvenes entre 15 y 24 años que no estudian, no trabajan y no reciben capacitación. Los resultados muestran que CSP tuvieron impacto positivo, pero no significativo en el PBI y la productividad en la región Loreto. El impulso es mínimo. Representa como máximo el 9.5% de las fluctuaciones en el PBI regional y 0.13% en la productividad. En relación al segundo aspecto el efecto es positivo, significativo y exiguo sobre el gasto per cápita del 40% más pobre. El efecto sobre el trabajo decente entre jóvenes de 15 y 24 años, de acuerdo al modelo pooled data, mostró un efecto estadístico, positivo y significativo, y en esa medida los ingresos del canon y sobrecanon no fomentaron la mejora en esta variable.
Inducción, Deducción y Fenomenología en la Investigación Psicológica Sobre Casos de Violencia Familiar
Authors: Sánchez Jiménez Hugo Manuel
Published: January 2022

En el presente artículo se enfatiza la importancia de los métodos inductivo, deductivo y fenomenológico que intervienen en la práctica e investigación de la Psicología forense, teniendo en cuenta el estado actual de las investigaciones en nuestro país en la temática de la violencia familiar. El avance del fenómeno de la violencia en nuestra sociedad exige profundizar en la investigación y realizar un correcto diagnóstico de los efectos de la violencia; es por ello que conocer sobre el empleo y las bases epistemológicas que demandan estos tres métodos, permitirá a los investigadores de la profesión afianzarse en la intervención integral de dichos casos.
Valores hematológicos y bioquímicos del axolotl (Ambystoma mexicanum) mantenidos en cautiverio en Lima, Perú
Authors: Anaya-Lavalle Brayan Alfonso , Morales-Cauti Siever
Published: January 2022

El axolotl o ajolote es un anfibio caudado utilizado en numerosos estudios biomédicos por su capacidad regenerativa. Actualmente se encuentra en la categoría de peligro crítico de extinción a consecuencia de la contaminación acuática, caza indiscriminada e introducción de especies invasoras en su medioambiente natural. El objetivo del presente estudio fue determinar los rangos de parámetros hematológicos y bioquímicos de axolotls cautivos en Lima, Perú, para que puedan ser utilizados como referencia durante la evaluación clínica en laboratorios biomédicos y consultorios veterinarios de especies no convencionales. El estudio se realizó en una colección privada de axolotls en el distrito de San Juan de Miraflores, Lima. Se emplearon 27 axolotls, los cuales fueron restringidos químicamente para realizar la colecta de sangre, lográndose establecer rangos referenciales para 13 parámetros hematológicos y 10 bioquímicos.
Contaminación de agua superficial de la periferia urbana de Puerto Maldonado, al sureste de la amazonia peruana
Authors: Ibana-Lopez Karla , Sihuay-Perales Mayra , Garate-Quispe Jorge , Araújo-Florez Julio , Herrera-Machaca Marx , Alarcón Aguirre Gabriel , Rodriguez-Achata Liset
Published: January 2022

El objetivo del estudio fue evaluar la contaminación de aguas superficiales en la periferia urbana de Puerto Maldonado (amazonia peruana), utilizando análisis biológicos, fisicoquímicos y microbiológicos. Las muestras de agua se colectaron en seis cuerpos de agua (dos ríos, tres quebradas y un lago). Los parámetros fisicoquímicos de cada sitio de estudio no superaron los límites del Estándar de Calidad Ambiental peruano (ECA), excepto el oxígeno disuelto en ríos cercanos a zonas urbanas. La contaminación de los recursos hídricos está relacionada con los vertidos de aguas residuales y la escorrentía de aguas pluviales. Así, los mayores puntos de contaminación fecal fueron en los ríos cercanos a las zonas urbanas, superando el límite establecido por el ECA para la conservación del medio acuático (UFC ml-1 >2000). En el río Madre de Dios, la concentración de coliformes fecales superó en 75 veces al máximo permitido por el ECA, indicando que los ríos Tambopata y Madre de Dios de Puerto Maldonado están fuertemente contaminados.
Utilización del extracto oleoso de Pleuroncodes monodon como pigmentante en el alimento balanceado de la trucha arcoíris (Oncorhynchus mykiss)
Authors: Montufar Paul , Churacutipa Mamani Marisol , Barriga-Sánchez Maritza
Published: January 2022

El objetivo del presente trabajo fue evaluar el extracto oleoso de la munida Pleuroncodes monodon en el alimento balanceado sobre la pigmentación del músculo de la trucha arcoíris (Oncorhynchus mykiss). Los tratamientos fueron T1: alimento formulado sin pigmento, T2 y T3: alimento con 70 y 90 mg de astaxantina natural/kg de alimento, respectivamente y, T4 alimento con pigmento sintético (70 mg de astaxantina/kg de alimento). Se registraron cada 15 días y durante 90 días los valores de color utilizando la regla colorimétrica de Roche SalmoFanR y los valores de L*, a*, b*, C* y H* de la zona dorsal y caudal de la trucha. Los resultados de las lecturas de color indicaron que los tratamientos T2, T3 y T4 obtenidos con la regla SalmoFanR no presentaron diferencias significativas entre ellas; no obstante, la medición obtenida con el colorímetro muestra diferencias de color del T4 con respecto al T2 y T3. Se concluye, que la adición de 70 mg de astaxantina natural por kilogramo de alimento logra la pigmentación similar a lo obtenido con la astaxantina sintética.
Primera aproximación de carga animal óptima en cuyes al pastoreo durante la época lluviosa en la sierra peruana
Authors: Anaya L. Liz , Huamán C. Amparo , San Martín H. Felipe , Ara G. Miguel , Carcelén C. Fernando , Jiménez A. Ronald
Published: January 2022

Se realizó una primera aproximación de la carga animal óptima en cuyes al pastoreo durante la época lluviosa en la sierra del Perú, utilizando una pastura perenne asociada conformada por Lolium multiflorum, Lolium perenne, Dactylis glomerata, Trifolium pratense, Trifolium repens y Medicago sativa en función a la ganancia de peso vivo individual y por unidad de área, consumo de alimento, conversión alimenticia, rendimiento de pastura, costos de producción y ratio beneficio costo. Se emplearon 132 cuyes machos G de 15 días de edad en un diseño de bloques completos al azar con tres ciclos de engorde de 60 días como bloque y cuatro tratamientos correspondientes a cargas de 400 (T1), 500 (T2), 600 (T3) y 700 (T4) cuyes/ha/año. Se trabajó en áreas de 200 m2 de pastura donde pastorearon grupos de 8, 10, 12 y 14 cuyes en T1, T2, T3 y T4, respectivamente. Los resultados demostraron que no hubo efecto de la carga animal sobre la ganancia de peso individual, consumo de alimento, conversión alimenticia y rendimiento de pastura (p>0.05). Los efectos sobre la ganancia por unidad de área y ratio beneficio costo (p<0.05) fueron consecuencia directa y esperada del diferente número de animales entre cargas animales. El rango de carga animal fue insuficiente para determinar una carga óptima, de manera que tentativamente se sugiere utilizar la carga de 700 cuyes/ha/año, por ser la carga que favorece lograr más cuyes con parámetros productivos similares a cargas menores y mejores parámetros económicos.
Rehabilitación y mantenimiento en cautiverio de ranas altoandinas (Telmatobius spp) decomisadas en la ciudad de Lima, Perú
Authors: Elías Piperis Roberto , Berenguel Cook Raúl , Reátegui Guzmán Erick , Weaver Thomas J.
Published: January 2022

Las ranas del género Telmatobius están entre las especies de fauna silvestre más traficadas en Perú debido a que son colectadas para ser usadas como fuente alimenticia o porque les atribuyen propiedades medicinales. Entre 2012 y 2013, el Laboratorio de Vida Silvestre de la Facultad de Medicina Veterinaria y Zootecnia de la Universidad Peruana Cayetano Heredia recibió y mantuvo cerca de 400 ranas altoandinas (Telmatobius culeus) de decomisos hechos en el Mercado de La Parada en La Victoria, Lima, por la Administración Técnica Forestal y de Fauna Silvestre de Lima. En este estudio se recopila información producto del trabajo en la rehabilitación y mantenimiento en cautiverio de estos ejemplares.
Calidad de semen bovino diluido y congelado en un diluyente con caseinato de sodio
Authors: Pérez Jackeline , Restrepo B. Giovanni , Usuga S. Alexandra
Published: January 2022

El objetivo del estudio fue evaluar el caseinato de sodio (CS) en la dilución y la congelación de semen bovino. Quince eyaculados provenientes de cinco toros fueron diluidos y congelados individualmente con un diluyente compuesto por tris-glicerol-ácido cítrico con 8% v/v de lipoproteínas de baja densidad (LDL) y suplementado con CS en cuatro tratamientos: CS 3% p/v (CS3), CS 4% p/v (CS4), CS 5% p/v (CS5) y sin CS (Control). Se evaluaron la movilidad y cinética (Sistema SCA®) y la integridad funcional de membrana (prueba HOS) del semen fresco, diluido y descongelado. Además, se evaluó la morfología y vitalidad (eosina-nigrosina) del semen fresco y diluido, y la integridad estructural de membrana (SYBR14/IP), la integridad acrosómica (FITC-PNA) y la capacidad fertilizante in vitro (FIV) del semen descongelado. El análisis estadístico de los parámetros de calidad espermática se realizó mediante modelos lineales y la comparación de las medias por la prueba de Tukey. El análisis estadístico de la FIV se realizó con la prueba de Kruskal-Wallis. CS3 produjo un incremento de la movilidad progresiva y la frecuencia de batido del semen descongelado (p<0.05). CS4 tuvo un efecto deletéreo sobre la movilidad progresiva del semen diluido, mientras CS4 y CS5 afectaron la movilidad, cinética e integridad de membrana del semen descongelado (p<0.05). No se encontraron diferencias para la FIV (p>0.05). La suplementación del diluyente de congelación con caseinato de sodio puede mejorar la calidad posdescongelación del semen bovino.
Efecto de la inclusión de harina de pisonay (Erythrina edulis) de tres edades de rebrote sobre las características productivas en cuyes (Cavia porcellus)
Authors: Cárdenas-Villanueva Ludwing A. , Ramos-Zuñiga Ruth , Huamán-Gamarra José L. , Ramirez Mena Eliseo
Published: January 2022

El objetivo del presente estudio fue evaluar el efecto de tres edades de rebrote y tres niveles de inclusión de harina de pisonay (Erythrina edulis) sobre el consumo y conversión alimenticia; la ganancia de peso, y el rendimiento de carcasa en el engorde de cuyes (Cavia porcellus). Se utilizó las hojas y los peciolos secados bajo sombra de árboles cosechados, y procesados mecánicamente a 2 mm de tamaño de partícula. Se utilizaron 120 cuyes machos mejorados, distribuidos en 10 tratamientos (3 edades de rebrote, tres niveles de inclusión de la harina y un grupo control con harina de alfalfa) durante 56 días. La ganancia de peso total y diaria, además de la conversión alimenticia tuvieron un comportamiento similar entre los tratamientos; el consumo del alimento fue menor con el tratamiento 8M30% (54.0 g/día) con respecto al CA20% (59.3 g/día) (p<0.05) y el rendimiento de carcasa fue mayor en 4M20% (73.5%) en comparación con la dieta control (71.1%) (p<0.05). El consumo del alimento (60.3 g/día) como la conversión alimenticia (5.3) fue mayor a los 12 meses de edad de rebrote (p<0.05) con respecto a los 4 y 8 meses que fueron similares entre sí. El rendimiento de carcasa fue similar (72%) con la inclusión de 10 y 20% y disminuyó (70.6%) con el 30% de harina de pisonay (p<0.05), . La harina de pisonay utilizado como insumo alimenticio para la elaboración de concentrado no afecta las características productivas en cuyes.
Descripción osteológica de la taruca (Hipocamelus antisensis) (d'Orbigny, 1834): II. Esqueleto axial
Authors: Zapata Coacalla Celso , Pacheco Curie Joel Iván , Arias Flores José Carlos
Published: January 2022

Hippocamelus antisensis (d'Orbigny 1834), llamado taruca comúnmente, es un ciervo que vive en Perú, Bolivia y Chile entre los 3500 a 5000 m, y es considerado como especie vulnerable. Se describe el esqueleto axial de la taruca con base a cuatro especímenes (dos machos y dos hembras), según autorización RDG N°158-2015-SERFOR-DGGSPFFS. Las piezas óseas se obtuvieron conforme a la técnica anatómica, la descripción está de acuerdo con la Nómina Anatómica Veterinaria y las medidas a lo descrito por Von den Driesch. En el cráneo el occipital no tiene una protuberancia del occipital muy sobresaliente, el hueso frontal se caracteriza por su apófisis del asta y por presentar hasta tres forámenes supraorbitarios, el lagrimal presenta una fosa del lagrimal profunda y una fisura cubierta por cartílago, el hueso incisivo y maxilar son alargados, en el maxilar existe la presencia de un alveolo dentario para el canino, la sínfisis de la mandíbula permanece hasta la edad adulta, el vómer se proyecta hacia caudal relacionándose con el hueso palatino, presenta 7 vértebras cervicales, 13 torácicas, 7 lumbares, 5 sacras y 7 coccígeas y el esternón con 7 esternebras, presenta una apófisis xifoides pronunciada. Se concluye que la cabeza es alargada por las características de los huesos maxilar e incisivo, la presencia de forámenes y las características de las astas en el hueso frontal pueden ser utilizados para su identificación, la existencia de la fosa del lagrimal profunda y una fisura cubierta por cartílago, las coanas están divididas por el vómer.
Effects of humate and neodymium on phytochemical levels in kale at different ontogenetic stages
Authors: Anteh J. D. , Timofeeva O. A. , Mostyakova A. A.
Published: January 2022

The increased global mortality caused by the rise in chronic diseases can be reduced by the consumption of antioxidant-rich foods. Leafy green kale (Brassica oleracea var. sabellica) has high nutritional value due to its high antioxidant content and its consumption is highly correlated with a reduced risk of developing some chronic diseases. The paper focuses on examining the effects of two different mineral nutrients – neodymium and potassium humate – on the accumulation of flavonoids, vitamin C, phenolic compounds, carotenoids and malondialdehyde (MDA) content in field-grown leafy green kale. Leaves from treated plants were collected at three stages of maturity –14 weeks, 18 weeks, and 22 weeks and subjected to spectrophotometric analysis. The results showed that the stimulatory effect of both mineral nutrients on the phytochemicals varied at the different growth stages - the highest significant effect of neodymium has been mostly observed at week 18 with high flavonoid, vitamin C, and carotenoid levels. Phenolic compounds for this variant are the same as in the control samples, while the level of malondialdehyde was reduced by 21.8%, signifying increased antioxidant activity. The rare earth element primarily maintained some phytochemical content at weeks 14 and 22. Following soil treatment with potassium humate, the levels of studied phytochemical compounds were either maintained or elevated at weeks 14, 18, and 22. Humic acid exerted the greatest decrease in malondialdehyde content in kale at week 14, indicating a reduction in the lipid peroxidation process in leaves. Accordingly, the harvest date of leafy green kale (Brassica oleracea var. sabellica) should depend on the type of mineral nutrient applied. The obtained results provide information that may be relevant to the production of functional varieties and enhance the nutritional and possibly the economic value of kale.
Functional state of the myometrium of rats under chronic in vivo effect of nanostructured ZnO and ТіО2 materials
Authors: Tsymbalyuk O. V. , Davydovska T. L. , Naumenko A. M. , Liashevych A. N. , Lupaina I. S. , Voiteshenko I. S. , Nuryshchenko N. Y. , Skryshevsky V. A.
Published: January 2022

The specificities of the structure and blood supply of the uterus facilitate a considerable accumulation of nanosized xenobiotics, including nanoparticles of metal oxides, in its tissues. Numerous in vitro and in vivo experiments demonstrated that nanoparticles of metal oxides (ZnO and TiO2) have significant cytotoxic activity, caused by oxidative stress induction. However, there is no information about the impact of these nanomaterials on the functional state of the myometrium under chronic exposure on the organism. Tenzometric methods and mechanokinetic analysis were used in our work to investigate the contractile activity of the myometrium of non-pregnant rats. The contractile activity was either spontaneous or induced by oxytocin (the uterotonic hormone) and acetylcholine (the agonist of muscarinic choline receptors) under chronic peroral intake of the ZnO and TiO2 aqueous nanocolloids into the organism. It was found that after burdening of rats with ZnO and ТіО2 aqueous nanocolloids there were no changes in the pacemaker-dependent mechanisms forming the frequency of spontaneous contractions in the myometrium, but there was a considerably induced increase in the AU index of contractions. It was shown that during the oxytocin-induced excitation of the myometrium under both chronic and short-term burdening of the rats with ZnO and TiO2 aqueous nanocolloids, the mechanisms that regulate the intracellular concentration of Ca2+ ions are the target for the nanomaterials. When the rats were burdened with ZnO aqueous nanocolloids for 6 months, during cholinergic excitation there was hyperstimulation of both M3-receptor-dependent mechanisms of Са2+ ions intake via the potential-governed Са2+-channels of L-type into the smooth muscles of the myometrium, and M2-receptor-dependent mechanisms, controlling the intracellular concentration of these cations. Thus, the regularities and mechanisms of the change in the functioning of uterine smooth muscles under chronic intake of the ZnO and TiO2 aqueous nanocolloids were determined in this study.
Features of skin wound healing in rats with experimental chronic kidney disease
Authors: Pavlov S. B. , Litvinova O. B. , Babenko N. M.
Published: January 2022

Chronic kidney disease negatively affects the morphofunctional state of all organs due to hemodynamic and metabolic disorders. Changes in the content of cytokines observed in kidney diseases, which regulate the processes of inflammation and tissue repair, can complicate the course of the wound process. This research aimed to study disorders in the process of skin wound repair due to changes in the dynamics of production of interleukins IL-1β, IL-6, IL-10, IL-4, growth factors bFGF and VEGF in animals with experimental chronic kidney disease. The levels of interleukins and growth factors were determined on the 7th, 14th and 28th days after surgical modeling of wounds in the blood of rats with experimental chronic kidney disease and animals of the control group. To assess the dynamics and quality of wound healing, a semi-quantitative histological analysis was performed. The study showed an increase in the content of pro-inflammatory interleukins in the group of sick rats: on the 7th day the level of IL-1β was 1.19 times higher, and IL-6 – 1.55 times, on the 14th day the level of IL-1β was 1.37 times in comparison with the control group. The maximum increase in the concentration of anti-inflammatory interleukins was noted on the 28th day: IL-4 was 2.10 times higher, IL-10 – 1.39 times higher than in the control group. The content of bFGF and VEGF in animals of the control group reached its maximum on the 7th day, and in animals with chronic kidney disease – on the 15th day after surgery. Semi-quantitative histological analysis showed a decrease in indicators in the group of sick animals: the number of fibroblasts and collagen deposition – on the 7th day, reepithelialization – on the 28th day. A persistent increase in the number of polymorphonuclear leukocytes was also noted at all periods of the experiment: by 1.38, 1.99, and 9.82 times – on the 7th, 14th, and 28th days, respectively. The study showed that the dynamics of the production of interleukins and growth factors were impaired in rats with chronic kidney disease. In the process of damage regeneration in sick animals, pro-inflammatory mechanisms prevailed with the involvement of a large number of immunocompetent cells, as a result, skin wounds took longer to heal.
GC-MS analysis of cuticular waxes and evaluation of antioxidant and antimicrobial activity of Chaenomeles cathayensis and Ch. × californica fruits
Authors: Lykholat Y. V. , Khromykh N. O. , Didur O. O. , Sklyar T. V. , Holubieva T. A. , Lykholat T. Y. , Lavrentievа K. V. , Liashenko O. V.
Published: January 2022

Fruit extracts of the Chaenomeles species are a rich source of compounds having health-promoting properties, while their distribution between the species and cultivars varies significantly depending on both genotype and environmental threats. This study aimed at discovering antioxidant and antimicrobial potential of the secondary metabolites of fruit and waxes of fruit cuticular of introduced Ch. cathayensis and Ch. × californica plants. The sum of detected polyphenols in the isopropanolic fruit extracts varied slightly between the species, while significant excesses in indices were seen for both species peel extracts as compared to pulp extracts. Antimicrobial assays carried out by disc diffusion method showed notable activity of the fruit peel and pulp extracts of both species against all tested Gram-negative and Gram-positive bacterial strains, and two Candida strains as well. Pseudomonas aeruginosa strain was the most resistant to the action of both fruit extracts, especially peel extracts of Ch. cathayensis fruits. As identified by gas chromatography-mass spectrometry (GC-MS) assays, chloroformic extracts from the fruits of cuticular waxes of Ch. cathayensis and Ch. × californica contained six prevailing fractions: aldehydes, alkanes, alcohols, esters, fatty acids and various terpenoids. The predominant compounds were tetrapentacontane (21.8% of total amount) and heptacosanal (23.1% of total), respectively in the cuticular waxes of Ch. cathayensis and Ch. × californica. Cinnamaldehyde, cis-9-hexadecenal, hexadecanoic acid, oleic acid, olean-12-ene-3,28-diol (3. beta), lupeol, diisooctyl phthalate, 9-octadecenoic acid, 1,2,3-propanetriyl ester, 1,3,12-nonadecatriene-5,14-diol and some other identified compounds are well-known for their bioactivity, indicating the feasibility of studying the antimicrobial potential of plant fruits.
Spoofing Attack Detection Method for UAV Navigation System
Authors: Basan Elena , Abramov Eugene , Basyuk Anatoly , Sushkin Nikita
Published: January 2022

An implementation of methods for protecting unmanned aerial vehicles (UAVs) from spoofing attacks of the global positioning system (GPS) to ensure safe navigation is discussed in this paper. The Global Navigation Satellite System (GNSS) is widely used to locate UAVs and is by far the most popular navigation solution. This is due to the simplicity and relatively low cost of this technology, as well as the accuracy of the transmitted coordinates. However, there are many security threats to GPS navigation. Primarily this is due to the nature of the GPS signal, the signal is transmitted in the clear, so an attacker can block or tamper with it. This study analyzes the existing GPS protection methods. As part of the study, an experimental stand and scenarios of attacks on the UAV GPS system were developed. Data from the UAV flight logbook was collected and an analysis of cyber-physical parameters was carried out to see an effect of the attack on the on-board sensors readings. Based on this, a new method for detecting UAV anomalies was proposed, based on an analysis of changes in UAV internal parameters. This self-diagnosis method allows the UAV to independently assess the presence of changes in its subsystems and identify signs of a cyberattack. To detect an attack, the UAV collects data on changes in cyber-physical parameters over a certain period of time, then updates this data. As a result it is necessary for the UAV to determine the degree of difference between the two time series of the collected data. The greater the degree of difference between the updated data and the previous ones, the more likely the UAV is under attack.
Methodology for Ensuring a Comfortable Microclimate State in a Smart Home Using an Ensemble of Fuzzy Artificial Neural Networks
Authors: Mozohin Andrey
Published: January 2022

Analysis of the application of smart home technology indicates an insufficient level of controllability of its infrastructure, which leads to excessive consumption of energy and information resources. The problem of managing the digital infrastructure of human living space, is associated with a large number of highly specialized solutions for home automation, which complicate the management process. Smart home is considered as a set of independent cyber-physical devices aimed at achieving its goal. For coordinated work of cyber-physical devices it is proposed to provide their joint work through a single information center. Simulation of device operation modes in a digital environment preserves the resource of physical devices by making a virtual calculation for all possible variants of interaction of devices between themselves and the physical environment. A methodology for controlling the microclimate of a smart home using an ensemble of fuzzy artificial neural networks is developed, with the example of joint use of air conditioning, ventilation and heating. The neural network algorithm allows you to monitor the parameters of the physical environment, predict the modes of cyber-physical devices and generate control signals for each of them, ensuring the joint operation of devices with minimal resource consumption and information traffic. A variant of practical implementation of a smart home climate control system on the example of a multifunctional educational computer class is proposed. Hybrid neural networks of air conditioning, ventilation and heating systems were developed. The testing of the microclimate control system of a multifunctional university classroom using hybrid neural networks was carried out, a programmable logic controller of domestic production was used as a control device. The goal of management based on cooperating cyber-physical devices is to achieve a minimum of power and information traffic when they work together.
The Urban Land Nexus– Challenges and Opportunities of Regularising Informal Settlements
Authors: Magina Fredrick Bwire , Kyessi Alphonce , Kombe Wilbard
Published: January 2022

Informal settlements in Tanzania accommodate more than 70% of the urban population. Owing to this, the Tanzanian government has undertaken several initiatives to address the growing size and number of informal settlements. One such initiative is regularisation which addresses security of tenure for residents of these settlements. Most of the people living in informal settlements lack legal land ownership and as a result properties in such settlements have relatively less value and lack security of tenure. Providing security of tenure is believed to encourage investment into informal households and facilitate the provision of urban services. This study aims to evaluate the process of regularisation in three Tanzanian settlements; Magengenu in Dar es Salaam (Tanzania’s largest city), Ibungilo and Isamilo in Mwanza city (the nation’s second largest city). Using qualitative data the paper explores the challenges and opportunities that emerged from regularisation. Findings indicate that the regularisation process has facilitated the issuance of title deeds, increased land value and security of tenure. However, a number of challenges were highlighted during regularisation. These include an over-emphasis on the protection of private rights while undermining public interests, a lack of harmonised cost for regularisation, and prolonged delays in completing the regularisation process. These require policy actions, particularly reviewing the national informal settlements regularisation guidelines, as a way to address the weaknesses emerging from regularisation projects in the studied settlements. We conclude that land regularisation remains an important tool to enhance livable cities and protect long-term public and private interests in land development. In order to achieve this, supportive policy actions are required to support the protection of public interests in land regularisation and harmonise the costs of regularisation.
Renal replacement therapy in heart transplant recipients
Authors: Poz I. L. , Strokov A. G. , Kopylova Yu. V. , Poptsov V. N. , Gautier S. V.
Published: January 2022

Kidney injury in cardiac transplant recipients is one of the most severe complications affecting both short- and long-term transplant outcomes. The need for renal replacement therapy (RRT) is determined not only and not so much by the degree of renal dysfunction, as by the need for correction of fluid balance and metabolic disorders. These circumstances are associated with the specificity of extracorporeal renal replacement therapy in donor heart recipients. In this review, we discuss the problems of early versus delayed initiation of RRT, anticoagulation and vascular access, advantages and disadvantages of continuous and intermittent techniques. Special attention is paid to chronic kidney injury and peculiarities of kidney transplantation in heart recipients.
Analysis of the odds ratio of developmental delay in children with biliary atresia 12 months after liver transplantation
Authors: Syrkina A. V. , Tsirulnikova O. M. , Pashkova I. E. , Silina O. V. , Chekletsova E. V. , Oleshkevich S. Yu.
Published: January 2022

Background. Liver cirrhosis occurring before 1 year of age can affect a child’s development. Liver transplantation is the only radical treatment for decompensated cirrhosis. In biliary atresia, cirrhosis develops during the first months of life. The duration of cirrhosis in biliary atresia may vary from palliative Kasai portoenterostomy (PE) to liver transplantation. Developmental abnormalities in children with biliary atresia have been shown to occur both before and after liver transplantation. Association between duration of liver cirrhosis and psychomotor development of children has been underestimated.

Objective: to determine the chances of developmental delay in children depending on the cirrhosis persistence duration.

Materials and methods. The study enrolled 83 children with biliary atresia (47 children underwent palliative Kasai PE, 36 children with liver transplantation did not undergo Kasai PE). All children had their psychomotor development assessed before PE and 12 months after PE using the Griffiths psychomotor developmental scale (translation and adaptation by E.S. Keshishian) for children up to 24 months of age. Statistical analysis was performed by calculating odds ratios with 95% confidence intervals.

Results. Comparative analysis showed that in the subgroup of children who underwent Kasai PE, cirrhosis persistence before transplantation was 2.6 months longer than in children without Kasai PE (p = 0.011). The odds of developmental delay in preparation for liver transplantation were 3.3 times higher in the subgroup of children who underwent Kasai palliative PE compared to children without palliative (95%, CI 1.35–8.31). The odds of developmental delay 12 months after liver transplantation were 4.4 times higher in the subgroup of children who underwent palliative Kasai PE than in children without the palliative care (95% CI 1.54–12.5).

Conclusion. Children who underwent liver transplantation after palliative surgical treatment had lower levels of psychomotor development than children without palliative Kasai PE both before and 12 months after liver transplantation (p = 0.0018, p = 0.01 respectively).
The role of apoptotic bone marrow cells in activation of liver regeneration
Authors: Onishchenko N. A. , Nikolskaya A. O. , Gonikova Z. Z. , Kirsanova L. A. , Shagidulin M. Yu. , Sevastianov V. I.
Published: January 2022

Objective: using an adoptive transfer model to study the cellular mechanisms involved in the formation of the initial stage of liver regeneration during intraperitoneal injection of a healthy recipient with apoptotic bone marrowderived mononuclear cells (BM-MNCs) from a donor after extended liver resection.

Materials and methods. Male Wistar rats (n = 40) were used to create a model of adoptive transfer of apoptotic BM-MNCs (a-BM-MNCs) taken from the donor after extended liver resection to a healthy recipient. During the experiments, the animals were divided into five groups. Four experimental groups with intraperitoneal injection of the same doses to the recipient: freshly isolated BM-MNCs (group 1); BM-MNCs subjected to apoptosis for 48 hours by storage at t = 4–6 °C in phosphate-buffered saline (PBS) (group 2) or in a Custodiol HTK solution (group 3). In group 4, the animals were injected with PBS after storing BM-MNCs in it. The control animals were animals injected with saline (group 5). For selection of effective modes of apoptosis induction, BM-MNCs stained with 7AAD after incubation in solutions were analyzed by flow cytometry. Targeted transfer of regenerative signals to the recipient was assessed by the mitotic activity of hepatocytes in the liver and tubular epithelium in the kidneys, as well as by the intensity of microstructural changes in the liver 24, 48 and 72 hours after injection of the studied material.

Results. BMC incubation in PBS and HTK for 48 hours at t = 4–6 °C provides the most effective accumulation of a-BM-MNCs in early apoptosis. It was shown that a-BM-MNCs retain the ability to target-focused transmission of regulatory signals to the liver supported by autophagy process during adoptive transfer. It was established that a-BM-MNCs (groups 2 and 3) in comparison to native BM-MNCs (group 1) at adoptive transfer increased the regenerative potential of the liver due to pronounced increase in the activity of autophagy processes and directed infiltration of immunomodulatory mononuclear cells in the liver.

Conclusion. a-BM-MNCs create a stronger basis for development and implementation of a targeted and effective regeneration program by enhancing autophagy processes and immunomodulatory effect on mononuclear cells, which are regenerative signal carriers.
Computer modeling of different shaped patches in classical carotid endarterectomy
Authors: Loginova V. G. , Zakharov Yu. N. , Kazantsev A. N. , Shokin Yu. I. , Evtushenko E. V. , Barbarash L. S. , Onishchenko P. S. , Klyshnikov K. Yu. , Ovcharenko E. A.
Published: January 2022

Objective: to construct geometric models of carotid bifurcation and build a computer modeling for carotid endarterectomy (CEA) operations with patches of various configurations.

Materials and methods. The method uses reconstructed models of a healthy blood vessel obtained from a preoperative computed tomography (CT) study of the affected blood vessel of a particular patient. Flow in the vessel is simulated by computational fluid dynamics using data from the patient's ultrasonic Doppler velocimetry and CT angiography. Risk factors are assessed by hemodynamic indices at the vessel wall associated with Wall Shear Stress (WSS).

Results. We used the proposed method to study the hemodynamic results of 10 virtual CEA operations with patches of various shapes on a reconstructed healthy artery of a particular patient. The reason for patch implantation was to ensure that the vessel lumen is not narrowed as a result of the surgery, since closing the incision without a patch can reduce the vessel lumen circumference by 4–5 mm, which adversely affects blood flow. On the other hand, too wide a patch creates aneurysmorphic deformation of the internal carotid artery (ICA) mouth, which is not optimal due to formation of a large recirculation zone. In this case, it was found that the implanted patch width of about 3 mm provides an optimal hemodynamic outcome. Deviations from this median value, both upward and downward, impair hemodynamics. The absence of a patch gives the worst of the results considered.

Conclusion: The proposed computer modeling technique is able to provide a personalized patch selection for classical CEA with low risk of restenosis in the long-term follow-up.