bluuebunny/crossref_metadata_2025 huggingface dataset:
LSTM‐Based Approach for Stable Identification of Modal Damping Ratio in Building Structures
Authors: Yun Da Yo , Oh Byung Kwan , Park Kanghyun , Park Hyo Seon
Published: January 2024

Modal parameters are used as safety assessment indicators for evaluating the structural integrity of buildings in various ways. In particular, the modal damping ratio plays a crucial role in accurately predicting the serviceability and safety of buildings, starting from the initial design stage. However, the identification results of the modal damping ratio can become unstable due to measurement time, initial configuration conditions used in the analysis, and nonstationary responses included in the structural response. To address the instability issue, this study proposes a long short‐term memory‐based frequency domain decomposition (FDD‐LSTM) method. The FDD‐LSTM method utilizes the acceleration response of the building as input data and the modal damping ratio obtained from the FDD method as output data, constructing an LSTM network model for the relationship between the acceleration response and modal damping ratio. The FDD‐LSTM method exhibited a discrepancy of less than 0.02% compared to the reference value of the modal damping ratio obtained through free vibration response. Furthermore, when applied to data acquired from an actual building, the method demonstrated a variance of approximately 5%. The proposed FDD‐LSTM method is validated for stability performance using a three‐degree‐of‐freedom numerical analysis model, a 3‐story steel frame structure model, and a 117‐story high‐rise building. The FDD‐LSTM method, trained on a large dataset, enables generalized estimation and addresses instability issues related to modal damping ratio.
Supplementary Table 1 from SLFN11 is a BRCA Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma
Authors: Akashi Hidehiko , Yachida Nozomi , Ueda Haruka , Yamaguchi Manako , Yamawaki Kaoru , Tamura Ryo , Suda Kazuaki , Ishiguro Tatsuya , Adachi Sosuke , Nagase Yoshikazu , Ueda Yutaka , Ueda Masashi , Abiko Kaoru , Kagabu Masahiro , Baba Tsukasa , Nakaoka Hirofumi , Enomoto Takayuki , Murai Junko , Yoshihara Kosuke
Published: January 2024

Supplementary Table 1
Figure S6 from Brentuximab Vedotin–Driven Microtubule Disruption Results in Endoplasmic Reticulum Stress Leading to Immunogenic Cell Death and Antitumor Immunity
Authors: Heiser Ryan A. , Cao Anthony T. , Zeng Weiping , Ulrich Michelle , Younan Patrick , Anderson Martha E. , Trueblood Esther S. , Jonas Mechthild , Thurman Robert , Law Che-Leung , Gardai Shyra J.
Published: January 2024

Supplementary Figure S6. Brentuximab vedotin’s multifaceted mechanism of action
Supplementary Figure 1 from SLFN11 is a BRCA Independent Biomarker for the Response to Platinum-Based Chemotherapy in High-Grade Serous Ovarian Cancer and Clear Cell Ovarian Carcinoma
Authors: Akashi Hidehiko , Yachida Nozomi , Ueda Haruka , Yamaguchi Manako , Yamawaki Kaoru , Tamura Ryo , Suda Kazuaki , Ishiguro Tatsuya , Adachi Sosuke , Nagase Yoshikazu , Ueda Yutaka , Ueda Masashi , Abiko Kaoru , Kagabu Masahiro , Baba Tsukasa , Nakaoka Hirofumi , Enomoto Takayuki , Murai Junko , Yoshihara Kosuke
Published: January 2024

Supplementary Figure Consort diagram of the cases used in this study.
Supplementary Figure S2 from Targeting NANOG and FAK via Cx26-derived Cell-penetrating Peptides in Triple-negative Breast Cancer
Authors: Mulkearns-Hubert Erin E. , Esakov Rhoades Emily , Ben-Salem Salma , Bharti Rashmi , Hajdari Nicole , Johnson Sadie , Myers Alex , Smith Iris Nira , Bandyopadhyay Smarajit , Eng Charis , Downs Erinn , Lathia Justin D. , Reizes Ofer
Published: January 2024

SPR sensograms demonstrating binding of Cx26 peptides to FAK or NANOG proteins.
Supplementary Methods from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
Authors: Li Wei , Sano Renata , Apatira Mutiah , DeAnda Felix , Gururaja Tarikere , Yang Muhua , Lundgaard Greta , Pan Chin , Liu Jing , Zhai Yongjiao , Yoon Woo Hyun , Wang Longcheng , Tse Chris , Souers Andrew J. , Lee Chih-Hung
Published: January 2024

Supplemental methods
Supplemental Figure 4 from Bruton's Tyrosine Kinase Inhibitors with Distinct Binding Modes Reveal Differential Functional Impact on B-Cell Receptor Signaling
Authors: Li Wei , Sano Renata , Apatira Mutiah , DeAnda Felix , Gururaja Tarikere , Yang Muhua , Lundgaard Greta , Pan Chin , Liu Jing , Zhai Yongjiao , Yoon Woo Hyun , Wang Longcheng , Tse Chris , Souers Andrew J. , Lee Chih-Hung
Published: January 2024

Supplemental Figure 4
Supplemental Methods from Delivery versus Potency in Treating Brain Tumors: BI-907828, a MDM2-p53 Antagonist with Limited BBB Penetration but Significant In Vivo Efficacy in Glioblastoma
Authors: Zhang Wenjuan , Vaubel Rachael A. , Oh Ju-Hee , Mladek Ann C. , Talele Surabhi , Zhang Wenqiu , Waller Katie L. , Burgenske Danielle M. , Sarkaria Jann N. , Elmquist William F.
Published: January 2024

Supplemental methods
Figure S3 from Delivery versus Potency in Treating Brain Tumors: BI-907828, a MDM2-p53 Antagonist with Limited BBB Penetration but Significant In Vivo Efficacy in Glioblastoma
Authors: Zhang Wenjuan , Vaubel Rachael A. , Oh Ju-Hee , Mladek Ann C. , Talele Surabhi , Zhang Wenqiu , Waller Katie L. , Burgenske Danielle M. , Sarkaria Jann N. , Elmquist William F.
Published: January 2024

Brain slice study to dissect orthotopic GBM from mouse brain. (A) Schematic of the study. (B) Representative image of mouse brain section marked with tumor region (bright green) and normal brain region.
Data from Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence
Authors: Sharma Monika , Barravecchia Ivana , Teis Robert , Cruz Jeanette , Mumby Rachel , Ziemke Elizabeth K. , Espinoza Carlos E. , Krishnamoorthy Varunkumar , Magnuson Brian , Ljungman Mats , Koschmann Carl , Chandra Joya , Whitehead Christopher E. , Sebolt-Leopold Judith S. , Galban Stefanie
Published: January 2024

Abstract
Therapeutic resistance remains a major obstacle to successful clinical management of diffuse intrinsic pontine glioma (DIPG), a high-grade pediatric tumor of the brain stem. In nearly all patients, available therapies fail to prevent progression. Innovative combinatorial therapies that penetrate the blood–brain barrier and lead to long-term control of tumor growth are desperately needed. We identified mechanisms of resistance to radiotherapy, the standard of care for DIPG. On the basis of these findings, we rationally designed a brain-penetrant small molecule, MTX-241F, that is a highly selective inhibitor of EGFR and PI3 kinase family members, including the DNA repair protein DNA-PK. Preliminary studies demonstrated that micromolar levels of this inhibitor can be achieved in murine brain tissue and that MTX-241F exhibits promising single-agent efficacy and radiosensitizing activity in patient-derived DIPG neurospheres. Its physiochemical properties include high exposure in the brain, indicating excellent brain penetrance. Because radiotherapy results in double-strand breaks that are repaired by homologous recombination (HR) and non-homologous DNA end joining (NHEJ), we have tested the combination of MTX-241F with an inhibitor of Ataxia Telangiectasia Mutated to achieve blockade of HR and NHEJ, respectively, with or without radiotherapy. When HR blockers were combined with MTX-241F and radiotherapy, synthetic lethality was observed, providing impetus to explore this combination in clinically relevant models of DIPG.

Our data provide proof-of-concept evidence to support advanced development of MTX-241F for the treatment of DIPG. Future studies will be designed to inform rapid clinical translation to ultimately impact patients diagnosed with this devastating disease.
Supplementary Figure 1 from T cell–Dependent Bispecific Therapy Enhances Innate Immune Activation and Antibody-Mediated Killing
Authors: Besla Rickvinder , Penuel Elicia , Del Rosario Geoff , Cosino Ely , Myrta Szymon , Dillon Mike , Lazar Greg A. , Nickles Dorothee , Spiess Christoph , Yu Shang-Fan , Polson Andrew G.
Published: January 2024

Gating strategy and time course of activation for circulating NK cells after Mosunetuzumab treatment.
Supplementary Figure.3 from The Tautomerase Activity of Tumor Exosomal MIF Promotes Pancreatic Cancer Progression by Modulating MDSC Differentiation
Authors: Jia Xuebing , Xi Jianbei , Tian Binle , Zhang Yuanyuan , Wang Zhilong , Wang Fan , Li Zheng , Long Jiang , Wang JianFei , Fan Guo-Huang , Li Qi
Published: January 2024

High expression of MIF in pancreatic cancer is associated with poor survival.
Supplementary Legends from Notch Signaling Regulates Immunosuppressive Tumor-Associated Macrophage Function in Pancreatic Cancer
Authors: Yan Wei , Menjivar Rosa E. , Bonilla Monica E. , Steele Nina G. , Kemp Samantha B. , Du Wenting , Donahue Katelyn L. , Brown Kristee L. , Carpenter Eileen S. , Avritt Faith R. , Irizarry-Negron Valerie M. , Yang Sion , Burns William R. , Zhang Yaqing , Pasca di Magliano Marina , Bednar Filip
Published: January 2024

Supplementary Legends
Table S2 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor
Authors: Etherington Mark S. , Hanna Andrew N. , Medina Benjamin D. , Liu Mengyuan , Tieniber Andrew D. , Kwak Hyunjee V. , Tardy Katherine J. , Levin Lillian , Do Kevin J. , Rossi Ferdinando , Zeng Shan , DeMatteo Ronald P.
Published: January 2024

Notable Module 3 genes
Table S1 from Tyrosine Kinase Inhibition Activates Intratumoral γδ T Cells in Gastrointestinal Stromal Tumor
Authors: Etherington Mark S. , Hanna Andrew N. , Medina Benjamin D. , Liu Mengyuan , Tieniber Andrew D. , Kwak Hyunjee V. , Tardy Katherine J. , Levin Lillian , Do Kevin J. , Rossi Ferdinando , Zeng Shan , DeMatteo Ronald P.
Published: January 2024

Flow cytometry antibodies
Supplementary Table S2 from Combination of Anti–PD-1 and Electroacupuncture Induces a Potent Antitumor Immune Response in Microsatellite-Stable Colorectal Cancer
Authors: Wang Yuan , Liu Fengyi , Du Xiaoxue , Shi Jiaqi , Yu Rui , Li Shuang , Na Ruisi , Zhao Ying , Zhou Meng , Guo Ying , Cheng Liang , Wang Guangyu , Zheng Tongsen
Published: January 2024

details regarding reagents
Supplementary Figure 2 from Spatial Distribution of Immune Cells Drives Resistance to Neoadjuvant Chemotherapy in Triple-Negative Breast Cancer
Authors: Donati Benedetta , Reggiani Francesca , Torricelli Federica , Santandrea Giacomo , Rossi Teresa , Bisagni Alessandra , Gasparini Elisa , Neri Antonino , Cortesi Laura , Ferrari Guglielmo , Bisagni Giancarlo , Ragazzi Moira , Ciarrocchi Alessia
Published: January 2024

Supplementary Figure 2. CD3 and CD20 expression analysis in AOIs comparing pCR and pNR patients
Supplementary Figure S5 from Combination of Anti–PD-1 and Electroacupuncture Induces a Potent Antitumor Immune Response in Microsatellite-Stable Colorectal Cancer
Authors: Wang Yuan , Liu Fengyi , Du Xiaoxue , Shi Jiaqi , Yu Rui , Li Shuang , Na Ruisi , Zhao Ying , Zhou Meng , Guo Ying , Cheng Liang , Wang Guangyu , Zheng Tongsen
Published: January 2024

Supplementary Figure S5 and legend
Data from The Tautomerase Activity of Tumor Exosomal MIF Promotes Pancreatic Cancer Progression by Modulating MDSC Differentiation
Authors: Jia Xuebing , Xi Jianbei , Tian Binle , Zhang Yuanyuan , Wang Zhilong , Wang Fan , Li Zheng , Long Jiang , Wang JianFei , Fan Guo-Huang , Li Qi
Published: January 2024

Abstract
Pancreatic cancer is a deadly disease that is largely resistant to immunotherapy, in part because of the accumulation of immunosuppressive cells in the tumor microenvironment (TME). Much evidence suggests that tumor-derived exosomes (TDE) contribute to the immunosuppressive activity mediated by myeloid-derived suppressor cells (MDSC) within the pancreatic cancer TME. However, the underlying mechanisms remain elusive. Herein, we report that macrophage migration inhibitory factor (MIF) in TDEs has a key role in inducing MDSC formation in pancreatic cancer. We identified MIF in both human and murine pancreatic cancer–derived exosomes. Upon specific shRNA-mediated knockdown of MIF, the ability of pancreatic cancer–derived exosomes to promote MDSC differentiation was abrogated. This phenotype was rescued by reexpression of the wild-type form of MIF rather than a tautomerase-null mutant or a thiol-protein oxidoreductase-null mutant, indicating that both MIF enzyme activity sites play a role in exosome-induced MDSC formation in pancreatic cancer. RNA sequencing data indicated that MIF tautomerase regulated the expression of genes required for MDSC differentiation, recruitment, and activation. We therefore developed a MIF tautomerase inhibitor, IPG1576. The inhibitor effectively inhibited exosome-induced MDSC differentiation in vitro and reduced tumor growth in an orthotopic pancreatic cancer model, which was associated with decreased numbers of MDSCs and increased infiltration of CD8+ T cells in the TME. Collectively, our findings highlight a pivotal role for MIF in exosome-induced MDSC differentiation in pancreatic cancer and underscore the potential of MIF tautomerase inhibitors to reverse the immunosuppressive pancreatic cancer microenvironment, thereby augmenting anticancer immune responses.
FIGURE 4 from Combined Inhibition of EZH2 and FGFR is Synergistic in BAP1-deficient Malignant Mesothelioma
Authors: Badhai Jitendra , Landman Nick , Pandey Gaurav Kumar , Song Ji-Ying , Hulsman Danielle , Krijgsman Oscar , Chandrasekaran Gayathri , Berns Anton , van Lohuizen Maarten
Published: January 2024

EZH2 inhibition together with FGFR inhibition is well tolerable and shows reduced tumor growth in xenograft models of mesothelioma. A, Schematic representation of the treatment schedule of the MTD. NSG mice were treated with a combination of AZD4547 (FGFRi) and GSK126 (EZH2i) or AZD457 and tazemetostat (EZH2i) for 28 consecutive days. B, Body weight of individual mice in the treatment group over time. Shown are C57BL/6 mice from the AZD4547/GSK126 cohort. C, NSG mice with BNC and NC xenografts were treated with vehicle, AZD4547 (7.5 mg/kg once daily), GSK126 (40 mg/kg once daily), or a combination. Shown is mean tumor volume over time (tumor volume ± SEM; n = 8 mice per treatment group). D, NSG mice with BNC and NC xenografts were treated with vehicle, AZD4547 (7.5 mg/kg once daily), tazemetostat (250 mg/kg twice daily), or a combination. Shown is mean tumor volume over time (tumor volume ± SEM; n = 8 mice per treatment group); P values were determined by using two-tailed unpaired Student t test; ∗, P < 0.05; ∗∗, P < 0.01, ∗∗∗, P < 0.001; and ∗∗∗∗, P < 0.0001.
Data from Combined Inhibition of EZH2 and FGFR is Synergistic in BAP1-deficient Malignant Mesothelioma
Authors: Badhai Jitendra , Landman Nick , Pandey Gaurav Kumar , Song Ji-Ying , Hulsman Danielle , Krijgsman Oscar , Chandrasekaran Gayathri , Berns Anton , van Lohuizen Maarten
Published: January 2024

Abstract
Malignant mesothelioma is a highly aggressive tumor with a survival of only 4–18 months after diagnosis. Treatment options for this disease are limited. Immune checkpoint blockade using ipilimumab and nivolumab has recently been approved as a frontline therapy, but this led to only a small improvement in overall patient survival. As more than half of patients with mesothelioma have alterations in the gene encoding for BAP1 this could be a potential marker for targeted therapies. In this study, we investigated the synergistic potential of combining EZH2 inhibition together with FGFR inhibition for treatment of BAP1-deficient malignancies. The efficacy of the combination was evaluated using human and murine preclinical models of mesothelioma and uveal melanoma in vitro. The efficacy of the combination was further validated in vivo by using BAP1-deficient mesothelioma xenografts and autochthonous mouse models. In vitro data showed sensitivity to the combined inhibition in BAP1-deficient mesothelioma and uveal melanoma tumor cell lines but not for BAP1-proficient subtypes. In vivo data showed susceptibility to the combination of BAP1-deficient xenografts and demonstrated an increase of survival in autochthonous models of mesothelioma. These results highlight the potential of this novel drug combination for the treatment of mesothelioma using BAP1 as a biomarker. Given these encouraging preclinical results, it will be important to clinically explore dual EZH2/FGFR inhibition in patients with BAP1-deficient malignant mesothelioma and justify further exploration in other BAP1 loss–associated tumors.
Significance:
Despite the recent approval of immunotherapy, malignant mesothelioma has limited treatment options and poor prognosis. Here, we observe that EZH2 inhibitors dramatically enhance the efficacy of FGFR inhibition, sensitising BAP1-mutant mesothelioma and uveal melanoma cells. The striking synergy of EZH2 and FGFR inhibition supports clinical investigations for BAP1-mutant tumors.
Two Japanese Families with Pigmented Paravenous Retinochoroidal Atrophy and HK1 Mutation: A Case Report
Authors: Sato Shigeru , Morimoto Takeshi , Fujikado Takashi , Tanaka Sayaka , Sai Sou , Tsujikawa Motokazu , Nishida Kohji
Published: January 2024

Hexokinase 1 (HK1) gene is the cause of autosomal dominant retinitis pigmentosa (RP) 79. To date, only E874K mutation has been reported as the causative mutation in patients with nonsyndromic RP. As a Caucasian RP case with a pathological variant of HK1 exhibiting pigmented paravenous retinochoroidal atrophy (PPRCA) phenotype was recently reported, we reviewed RP79 cases in our Japanese RP cohort. Consequently, 2 Japanese patients, who were diagnosed with RP79 by genetic tests in our RP cohort, were included in this study. Patient 1 was a 60-year-old woman. Fundus examination revealed symmetrical donut-shaped retinal degeneration, with pigment deposition avoiding the macula. Moreover, degeneration extended in a peripheral direction along the vessels like a starfish, and degeneration was observed around the veins and arteries. Patient 2 was a 75-year-old man. Fundus examination revealed symmetric macula-avoiding donut-shaped retinal degeneration, with paravenous protruding degeneration along the blood vessels like in case 1. Both Japanese cases, which belonged to two separate families, had the same HK1 pathogenic mutation, with a phenotype of PPRCA. Furthermore, atrophy along retinal arteries was noted. Reviewing previous nonsyndromic RP79 cases revealed symptoms that are believed to be those of PPRCA. Ultra-widefield fundus imaging, especially ultra-widefield fundus autofluorescence, has been useful in detecting PPRCA. If these devices become widely available, more cases may be discovered in the future because PPRCA can be used as a clue to suspect RP79, and Sanger sequencing may be used to identify pathogenic mutations in HK1 at a lower cost and more easily than using whole-exome sequencing.
Growth Factors and Microneedling in Alopecia Areata: A Narrative Review
Authors: Almutlq Malak M. , Bukhari Abrar E.
Published: January 2024

Alopecia areata (AA) is an autoimmune condition that causes non-scarring hair loss on the scalp or other hair-bearing surfaces. Various signalling molecules regulate the hair cycle and hair follicle regeneration. These include genes, growth factors, nuclear receptors, cytokines, and subcellular signalling pathways. Growth factors can cause the vascular endothelium and dermal fibroblasts to proliferate, extend the anagen phase, and delay the initiation of catagen in the hair follicle, thereby promoting hair growth. Microneedling causes the release of growth factors and has been shown to help high-molecular-weight drugs penetrate the stratum corneum and hair follicles. These recent discoveries regarding the pathogenesis of AA have resulted in the development of promising therapies. Herein, this article reviews the use of growth factors and microneedling in the treatment of AA and explores their efficacy and safety. Treatment with growth factors and microneedling appears to be highly effective for AA, with no major adverse effects, and may provide a new option for hair regeneration therapy. To support the efficacy of growth factors and microneedling for AA treatment, additional large-scale studies of patients with AA are needed.
Customer Preference Shift: A Laundry Shop Experience
Authors: Narsico Lalaine O. , Narsico Peter G.
Published: January 2024

This study was an attempt to investigate the dynamics of a phenomenon that happened in a self-service laundry shop. In the beginning, very few customers would patronize it. But little by little more customers began to frequent the shop and most of these were from the locality. The preference shift of customers was interesting. This situation was believed to reveal some findings that could be used in similar businesses. Qualitative was the method and specifically a case study. It made use of observations and informal interviews of two laundry attendants who have been in at least two years in the laundry shop, one maintenance personnel who has been present since the start of the establishment, and over five hundred regular customers. The observations and interviews revolve around the areas of concern at the start of the laundry shop, key characteristics of regular customers, reasons why customers made the preference shift from going with what they used to do towards availing the new service package, and the challenges encountered in the process of service delivery. Conclusions on the four areas of inquiry were; service value realization was slow and this influenced the initiatives that were made; customer satisfaction was dependent on price, service quality, and rapport and subsequently led to referrals; customers realized that it is more convenient to avail of the new service package, and competition served as a reason to improve service delivery; and sustained customer loyalty and organizational citizenship provide an environment for growth.
An Investigation about Education as Envisioned by Confucius and Its Implications for Contemporary Moral Education
Authors: Shaoan Md Mirajur Rhaman , Jamil Bushra , Musengamana Irene , Mahamud Akash , Chineta Okoye Maureen , Arif Muhammad , Namanyane Tebatso , Akter Jesmin
Published: January 2024

This study investigates Confucius' views on education and their rel-evance in the 4.0 era. Confucius is known as "the great model teach-er for centuries" for his dedication to education and his thoughts regarding its role, purpose, substance, and teaching techniques. Con-fucius founded Confucianism. Confucius felt education should be a right for everyone, not just the affluent. "No class difference in school" quickly transforms people's educational views. It makes formal schooling possible for most individuals. The idea of Confu-cius is innovative because people from all backgrounds desire jus-tice and equality in education. However, a synthesis of Confucius' education concepts based on past research adds to the literature on educational philosophy. Confucius's thoughts help people world-wide understand the incredible education ideas that have ever de-veloped in moral education. The results of this research can be guid-ed and affect modern educational authorities and policymakers.
Pre-Service Teachers’ Perceptions on Their Professional Identity Development (PID)
Authors: Liwanag Belinda A.
Published: January 2024

This research is focused on the perceptions of the pre-service teachers’ Professional Identity Development (PID). The respondents included 16 pre-service teachers from a private teacher education institution. It employed a descriptive narrative design with the qualitative method of collecting data using interview questionnaire and focus group discussion guideline as instruments. The findings showed all the shared experiences were perceived to be contributory to the development of the professional identity of the Pre-service Teachers (PTs) in the competencies stipulated in the Philippine Professional Standards for Teachers (PPST). Results of the interview done individually and as a group revealed how PTs perceived their professional identity development, which is essentially like the competencies of Stage 1 (Beginning Teacher). These include 1) Exhibiting mastery of concepts and pedagogy; 2) Effectiveness in communicating concepts; 3) Proficiency in information and communication technology (ICT) utilization; 4) Creating safe and conducive learning environment (classroom management); 5) Flexibility with the diverse learners; 6) Efficiency in lesson planning; 7) Consistency in reporting and monitoring learners’ progress; 8) Actively collaborating with colleagues and participating in the school community; and 9) Pursuing of continuous professional development. It proposes up-skilling and re-skilling of pre-service teachers which will all lead to the formation of a competent beginning teacher in the 21st century.
Differences in College Lecturers’ Ratings of Principals Instructional Leadership: A Jamaican Perspective.
Authors: Nevins-Bennett Cerease
Published: January 2024

The purpose of this quantitative study is to determine how lecturers rated their principals as instructional leaders and to examine the differences in lecturers’ ratings of principals’ instructional leadership based on the demographic characteristics of gender, age range, lecturing status, number of years current principals have been employed to the colleges. and the highest level of educational attainment of the current principals.  A survey that adopted the Principal Instructional Management Rating Scale (PIMRS) was used to collect data from 170 participants purposively. Overall, lecturers had moderately high ratings of principals’ instructional leadership within the colleges. There were no statistically significant differences in the ratings of lecturers based on age range and the number of years the current principal has been employed within the colleges. Male lecturers rated their principal higher than female lecturers on the dimension of creating a positive college climate. Adjunct lecturers gave their principals a higher rating than full-time lecturers on the dimension of managing instructional programs.  Principals that had a master’s degree as their highest educational attainment were rated higher by the lecturers on the dimension of defining the college mission. This study contributes to the body of knowledge by filling the gap at the college level.
Exploring Socio-Economics and Its Role in the Oral Health Care of Patients in A Philippine Government Hospital
Authors: Alas Carmi Angeline , Candelaria Emilio Paul , Canlas Jocelyn , Patacsil Jaya Grace , Malang Bernandino P.
Published: January 2024

Despite the availability of dental services and educational programs, as well as, established national health system responses, and oral health interventions and procedures, oral health problems (dental caries, gum diseases and unmet dental needs) persist in the Philippines. The aim of this study was to investigate the socioeconomic factors in terms of sex, age, marital status, educational attainment, occupation, and monthly income and their effect on the oral health awareness in terms of benefit and practices. A total of 100 patients from a selected government hospital were surveyed. The respondents were asked to answer a standardized questionnaire about their socioeconomic status, awareness on the benefits of oral health care, and awareness on the practices for oral health care. Chi-Square Test for Independence was used to identify which demographic and socioeconomic indicators determined the level of awareness of the respondents on the benefits of and practices for good oral health. The Chi-Square Test showed that only sex had a significant relationship with the awareness on the benefits of good oral health (p-value = 0.05). All the other indicators had insignificant effects; Age group (p-value = 0.435), Civil Status (p-value = 0.443), Education (p-value = 0.244), Employment status (p-value = 0.722), Income (p-value = 0.986). For the awareness on good oral practice, both sex and civil status showed a significant relationship (p-values 0.028 and 0.01). For the other indicators, null hypothesis was accepted; Age group (p-value = 0.61), education (p-value = 0.914), employment status (p-value = 0.334), income (p-value = 0.64).   The results of this study are in line with the Andersen Healthcare Utilization Model, which holds that people's use of healthcare services is influenced by several predisposing, enabling, and need-related factors. The knowledge of, and observance of, good oral health is essential in determining the need for oral healthcare. Moreover, a variety of socioeconomic and personal factors (enabling and predisposing) are crucial in facilitating or impeding people's ability to access and make use of oral healthcare services. Addressing these issues and promoting education and knowledge about the value of excellent oral health practices are crucial for good oral health.
Safety, Security, and Disaster Preparedness Plan of AIMS as Perceived by Internal Stakeholders: Towards the Enhancement of Institutional Safety and Security Plan
Authors: Cabasal Maria Celia C. , Lusiniara Manolito T. , Alumia Amador B.
Published: January 2024

Employing descriptive-comparative design, the perception towards the safety, security and disaster preparedness of AIMS was taken from 167 employees and 343 students and strategically compared using T-test and analysis of variance (ANOVA). A standardized questionnaire adapted from the School Safety and Security Checklist by the New York State Police and the Virginia State Education Department was used as instrument during the data gathering period held last 1st Trimester of school year 2022-2023. Demographic profile and mean perception were also statistically treated using frequency, percentage and weighted mean. Based on the results, most of the employee respondents are newly-hired, single, not over 30 years old, physically fit and majority are females. They agreed that AIMS management have a safety and security management plan for its internal stakeholders. However, there are significant differences on their perception when grouped by Department, Position, and Years of Service at AIMS. Specifically, employees who are older and more mature seek improvement and enhancement on the services, facilities, and policies pertaining to safety.

 On the other hand, majority of the student respondents are male, BSMT first year students and claimed to be physically fit. Their perception towards the safety and security management of AIMS were higher compared to the employees. However, no significant difference was shown on their perception towards the safety and security management plan of AIMS when grouped according to their profile. For the school grounds, both respondents imply the need for parking facility improvement while on the school interior, it is recommended to conduct a psychological capability training and access to conflict resolution under the initiative of the Regiment Department.
Potential Association of Strongyloides stercoralis and its effectivity against Type 2 Diabetes Mellitus: A Systematic Review of Scientific Attestation
Authors: Alimpolos Jean A. , Martinez Christian Ray A. , Morris Navy May G. , Solano Roel Nickelson P.
Published: January 2024

The association of Strongyloides stercoralis in Type 2 Diabetes mellitus has put on a spotlight on various researchers after the discovery of S. stercoralis's capability to conduct immunomodulation through lowering the production and release of cytokines, all of which provide a contradictory action towards the development of T2DM. T2DM results from a high number of macrophages that secrete cytokines and chemokines abnormally, which affects the B-pancreatic cells and leads to insulin resistance. However, regardless of this information, the linkage of the immunomodulation mechanism of S. stercoralis infection against T2DM still needs clarification and further validation. Thus, this systematic review was conceptualized to identify if there is a direct association between S. stercoralis and T2DM, including the effects of the helminth on patients with such a disease, and the underlying factors related to this relationship. Studies for the review were collected in the following databases: PubMed, ProQuest, Wiley, Open Access Theses and Dissertations (OATD), Internet Archive Scholars, and Elsevier. The 2020 Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) criteria was utilized to identify and screen eligible studies for review and among the chosen articles, three have suggested a direct association between S. stercoralis infection and T2DM, while two studies proved the absence of an association by statistical and clinical characteristics. These limited findings and conflicting evidence for a direct link between S. stercoralis and T2DM may indicate that the comorbidity of both factors points more toward an indirect relationship.
Filipino Work Values and Job Satisfaction among Teachers of Selected Elementary Schools in the Division of Zambales
Authors: Laurenio Jr Welmer A. , Cabal Esmen M.
Published: January 2024

The study investigates the relationship between work values and job satisfaction among teachers, aiming to understand how teachers' values influence their overall job satisfaction. Specifically, the focus is on Filipino work values among elementary school teachers in the Division of Zambales. A survey questionnaire was employed to assess the work values and job satisfaction of teacher-respondents. Results revealed a demographic profile of primarily female teachers in the early middle-aged group, married, Roman Catholic, Master's degree holders, with substantial teaching experience, occupying the position of Teacher I, and earning an entry-level monthly income. Filipino work values received high ratings, emphasizing their significance in shaping professional attitudes. Teacher-respondents expressed a high level of job satisfaction. Significant differences in Filipino work values were identified, including intellectual achievement orientation, interpersonal values, managerial values, material values, occupational values, religious values, organizational values, and variety values, based on various demographic factors. Similarly, significant differences in job satisfaction were noted concerning job security and job responsibilities. The study established a significant relationship between Filipino work values and job satisfaction among elementary teacher-respondents. Recommendations include a thorough evaluation of work values by the Human Resource Management (HRM) Office before employee promotion. Future research should expand the scope to validate and generalize findings, contributing to a more comprehensive understanding of Filipino work values and job satisfaction among teachers.
Ciclo 22: uma experiência de extensão e formação na USP
Authors:   Universidade de São Paulo. Faculdade de Educação, Vidal Diana Gonçalves
Published: January 2024

Ciclo 22 teve como objetivo divulgar atividades realizadas pela comunidade uspiana em torno do bicentenário da Independência do Brasil, centenário da Semana de Arte Moderna e do movimento modernista no Brasil; além de criar um ambiente de discussão sobre o presente e o futuro do país. O projeto Ciclo 22 surgiu assim como um meio de dar visibilidade às diversas ações promovidas pelas Unidades da USP, aglutinando-as em um único portal (https://ciclo22.usp.br/) e valendo-se de mídias sociais para divulgação tanto à própria comunidade uspiana, quanto à toda a sociedade. Compreendendo que a produção de conhecimento científico das várias áreas de conhecimento deveria chegar à escola pública, o Ciclo 22 não apenas vasculhou as iniciativas desta natureza já existentes na USP, como criou formas de disseminação como vídeos e podcasts. À sua clara missão extensionista, o projeto acrescentou a dimensão formativa. Além das parcerias com a PRCEU, PRPG e Jornal da USP, iniciadas em 2021, o ano de 2022 inaugurou a relação com a Rádio USP, que passou a veicular quinzenalmente o podcast Ciclo 22 no vestibular. Ao todo foram produzidos 19 episódios. Quatro alunos de graduação e duas pós-Doutorandas foram responsáveis pela produção de conteúdos do site, do Jornal e da Rádio USP, atuando em todas as etapas do processo e propondo soluções, apreciadas em reuniões quinzenais da equipe. O expediente favoreceu a profissionalização dos estagiários e a capacitação das pós-doutorandas no exercício de orientação e da gestão de projetos, bem como ofereceu a todos os envolvidos a oportunidade de conhecer melhor a USP e o trabalho desenvolvido pelas Unidades, pesquisadores, docentes, alunos, órgãos administrativos e cursinhos populares. Foi, de fato, uma imersão nas iniciativas levadas a cabo pela comunidade uspiana nas suas várias vertentes.
ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban
Authors: Ren An-Jing , Wei Chunchun , Liu Ya-Jin , Liu Mengna , Wang Ping , Fan Juan , Wang Kai , Zhang Sha , Qin Zhenbang , Ren Qiu-Xiao , Zheng Yanjun , Chen Yu-Xia , Xie Zhifang , Gao Ling , Zhu Yi , Zhang Youyi , Yang Huang-Tian , Zhang Weiping J.
Published: January 2024

BACKGROUND:

Intracellular Ca
2+
cycling determines myocardial contraction and relaxation in response to physiological demands. SERCA2a (sarcoplasmic/endoplasmic reticulum Ca
2+
-ATPase 2a) is responsible for the sequestration of cytosolic Ca
2+
into intracellular stores during cardiac relaxation, and its activity is reversibly inhibited by PLN (phospholamban). However, the regulatory hierarchy of SERCA2a activity remains unclear.

METHODS:

Cardiomyocyte-specific ZBTB20 knockout mice were generated by crossing ZBTB20
flox
mice with Myh6-Cre mice. Echocardiography, blood pressure measurements, Langendorff perfusion, histological analysis and immunohistochemistry, quantitative reverse transcription-PCR, Western blot analysis, electrophysiological measurements, and chromatin immunoprecipitation assay were performed to clarify the phenotype and elucidate the molecular mechanisms.

RESULTS:

Specific ablation of ZBTB20 in cardiomyocyte led to a significant increase in basal myocardial contractile parameters both in vivo and in vitro, accompanied by an impairment in cardiac reserve and exercise capacity. Moreover, the cardiomyocytes lacking ZBTB20 showed an increase in sarcoplasmic reticular Ca
2+
content and exhibited a remarkable enhancement in both SERCA2a activity and electrically stimulated contraction. Mechanistically, PLN expression was dramatically reduced in cardiomyocytes at the mRNA and protein levels by ZBTB20 deletion or silencing, and PLN overexpression could largely restore the basal contractility in ZBTB20-deficient cardiomyocytes.

CONCLUSIONS:

These data point to ZBTB20 as a fine-tuning modulator of PLN expression and SERCA2a activity, thereby offering new perspective on the regulation of basal contractility in the mammalian heart.
Amoenoboletus brachysporus (Boletaceae), a new species from Southern China
Authors: LI TING , ZHONG GUORUI , LI TAIHUI , DENG WANGQIU , ZHANG MING
Published: January 2024

Amoenoboletus brachysporus is described as a new species from Southern China. Morphologically, it is closely related to A. granulopunctatus and A. mcrobbii, but distinguished by its relatively larger basidiomata with the pileus covered with conspicuous greyish yellow to yellowish brown patches or coarse fibrillose squamules, longer and broader stipes densely covered with dark red, appressed squamules, and obviously shorter basidiospores (7–9 × 5–6.3 μm). Phylogenetically, newly generated sequences from the new species form a distinct clade within the genus Amoenoboletus. Detailed morphological descriptions, colour photographs of the new species and comparisons with closely related taxa are presented.
Radiographic Investigation of Differences in Static Anterior Tibial Translation With Axial Load Between Isolated ACL Injury and Controls
Authors: Cance Nicolas , Dan Michael J. , Pineda Tomas , Demey Guillaume , Dejour David H.
Published: January 2024

Background:

Static anterior tibial translation (SATT) is radiographically measured to show the amount of tibial translation during the single-leg stance, and thus it is representative of the physiological axial load subjected to the anterior cruciate ligament (ACL) during the stance. Increased SATT has been associated with increased posterior tibial slope (PTS) and is also associated with increased graft failure.

Purpose:

To compare the SATT value in a control population with that in a population with an isolated ACL injury, as well as to compare the effect of tibial slope on SATT between the 2 groups.

Study Design:

Cohort study; Level of evidence, 3.

Methods:

A consecutive series of patients without ligamentous or meniscal injuries between 2019 and 2022 was reviewed. A matched consecutive cohort of patients with nonacute ACL injuries (surgery between 6 and 12 weeks after injury) without concomitant pathology was reviewed. Preoperative SATT and PTS were measured with a previously validated technique on lateral weightbearing knee radiographs. The SATT value was determined, and regression analysis was performed to investigate the relationship between SATT and PTS.

Results:

In total, 101 controls and 115 patients with an ACL injury were included in this study. The mean SATT was 1.31 mm (SD, 2.44 mm) and the mean PTS was 10.61° (SD, 3.28°) in the control cohort. The SATT was larger (mean, 2.27 mm; SD, 3.36 mm) in the ACL-injured cohort despite the tibial slope measurement being less in the ACL-injured cohort (mean, 9.46°; SD, 2.85°; P = .016). Linear regression analysis showed that for every 1° of increase in PTS, there was a 0.34-mm increase in SATT in the control cohort; however, there was a greater increase of 0.5 mm for every 1° of increase in PTS in the ACL-injured cohort. We found no significant differences in SATT when the cohorts were compared by age ( P = .26) or sex ( P = .10).

Conclusion:

The present study reports a reference SATT value of 1.31 mm (SD, 2.44 mm) in a non–ACL-injured cohort, which was lower than in the ACL-injured cohort (mean, 2.27 mm; SD, 3.36 mm). The effect of slope on weightbearing anterior tibial translation was greater in the ACL-injured population than in the control cohort.
Potential induction of hyperkeratosis in rats’ cervi by gentamicin via induction of oxidative stress, inflammation and apoptosis
Authors: Abdelzaher Walaa Yehia , Attya Mina Ezzat , Zeen El-Din Mohamed Ahmed , El Satae Alaa Gamal , Mohamed Hatem A , Rofaeil Remon R
Published: January 2024

The present study aimed to identify the possible effect of gentamicin (GEN) in Rats’ Cervi. Estradiol Valerate (EV) was used to induce cervical hyperkeratosis. GEN was administered in absence of EV. Serum and cervical GEN concentration were determined. Levels of malondialdehyde (MDA), total nitrites/nitrate (NOx), reduced glutathione (GSH), tumor necrosis factor-α (TNF-α), sirtuin type 1 (Sirt1) and nuclear factor (erythroid-derived 2)-like-2 factors (Nrf2) were measured in cervix tissue. Expression of BAX and Bcl2 were determined. Cervical histopathological examination was done. EV and GEN significantly increased MDA, NOx, TNF-α and BAX/Bcl2 ratio with decrease in GSH, Nrf2 and Sirt1 levels in cervical tissue. Histopathological picture of diffuse and marked hyperkeratosis was detected in EV and GEN groups. In conclusion, GEN-induced cervical hyperkeratosis via induction of oxidative stress, inflammation and apoptosis.
A Study on Attitude Towards Social Networking Among Adolescents and Parents
Authors: Mathur Tripti , Sharma Ratna Dixit
Published: January 2024

The purpose of this study is to know how students in school and parents perceive social networks. A random sample of 50 adolescents aged 17–21 and 50 parents aged 45–48 irrespective of gender were selected randomly from students in the eleventh and twelfth grades with their parents in Ambala, Haryana, India. A self-developed questionnaire consisting of 60 items about social networking was used, of which half of the items were in favour and half not in favour of social networking. The scoring of the questionnaire was done using scores 1 to 7 correlating to the options from ‘strongly disagree’ to ‘strongly agree’. Descriptive analysis and part–whole correlations and t-ratios were used to analyse the obtained data.

The difference in opinion between parents and adolescents about social networking is more evident when one considers the generation gap, income group and rural and urban groups. The attitude of parents, teachers and adolescents towards social networking sites is neutral. Social networking sites are both a boon and a curse, depending upon the level of awareness pertaining to the different aspects such as privacy, accessibility and the purpose for which they are being used.
Digitalization, Spillover and Environmental, Social, and Governance Performance: Evidence From China
Authors: Gu Jiafeng
Published: January 2024

There is growing interest in the relationship between digitalization and environmental, social, and governance (ESG) performance, but existing research focuses on the one-way relationship and ignores the two-way mechanism. Based on a sample of 3335 listed companies in China in 2020, this study adopts a spatial simultaneous equation model to investigate the bidirectional mechanism between companies’ digitalization and ESG performance. The results show that digitalization and ESG performance have a significant positive two-way mechanism; digitalization enhances ESG performance, while ESG performance promotes digitalization. The results also indicate a significant positive intra-industry spillover effect for both digitization and ESG performance. Further research shows that the relationship between digitization and ESG performance does not differ depending on the definition of spatial weights, however, the spillover effects do differ depending on the definition of spatial weights.
FLOW: Flow dysfunction of hemodialysis vascular access: A randomized controlled trial on the effectiveness of surveillance of arteriovenous fistulas and grafts
Authors: Zomer Bianca , Ruiter Matthijs S , Dekker Friedo W , Goertz Ellen GD , de Haan Michiel W , Hemmelder Marc HH , Hiligsmann Mickaël JC , Konijn Wanda S , van Loon Magda M , Maessen José MC , Mees Barend ME , Rotmans Joris I , Schurink Geert WH , Vleugels Marie-José JPJ , Snoeijs Maarten GJ
Published: January 2024

Introduction:

It is assumed that identification and correction of asymptomatic stenoses in the vascular access circuit will prevent thrombosis that would require urgent intervention to continue hemodialysis treatment. However, the evidence base for this assumption is limited. Recent international clinical practice guidelines reach different conclusions on the use of surveillance for vascular access flow dysfunction and recommend further research to inform clinical practice.

Methods:

The FLOW trial is a double-blind, multicenter, randomized controlled trial with a 1:1 individual participant treatment allocation ratio over two study arms. In the intervention group, only symptomatic vascular access stenoses detected by clinical monitoring are treated, whereas in the comparison group asymptomatic stenoses detected by surveillance using monthly dilution flow measurements are treated as well. Hemodialysis patients with a functional arteriovenous vascular access are enrolled. The primary outcome is the access-related intervention rate that will be analyzed using a general linear model with Poisson distribution. Secondary outcomes include patient satisfaction, access-related serious adverse events, and quality of the surveillance process. A cost effectiveness analysis and budget impact analysis will also be conducted. The study requires 828 patient-years of follow-up in 417 participants to detect a difference of 0.25 access-related interventions per year between study groups.

Discussion:

As one of the largest randomized controlled trials assessing the clinical impact of vascular access surveillance using a strong double-blinded study design, we believe the FLOW trial will provide much-needed evidence to improve vascular access care for hemodialysis patients.