bluuebunny/crossref_metadata_2025 huggingface dataset:
USAGE OF THE MOODLE PLATFORM FOR THE PURPOSE OF FORMATION OF COMMUNICATIVE COMPETENCE IN THE PROCESS OF TEACHING THE PHILOSOPHY COURSE IN HIGHER EDUCATION INSTITUTIONS
Authors: Kyrylenko Kateryna , Stratiuk Viktoriia , Boiko Liudmyla , Beniuk Olesia , Kunderevich Olena
Published: December 2021

The purpose of the article is to substantiate the expediency of directing the computer-oriented learning environment to the formation of communicative competence of the future graduate of the higher education institutions. The forms of work of the university lecturer with students in the direction of formation of the communicative educational environment are described, on the example of the use of computer-based learning tools of the Moodle platform, in the process of teaching the “Philosophy” course. The following research methods are used: pedagogical observation, monitoring, analysis, generalization, concretization, systematization. The scientific novelty of the research is to study the communicative capabilities of the Moodle learning platform, ways of using them in teaching the “Philosophy” course in the university in order to form the communicative competence of future graduates and highlight the relevant experience of the Department of Philosophy and Pedagogy of Kyiv National University of Culture and Arts (KNUC&A) in attracting them to work with students. The necessity of the formation of communicative competence as the basic integral characteristic of the person, the direction of educational and training activity of the university of any profile in this direction is substantiated. It is demonstrated that the subject content of the “Philosophy” course provides the formation of communicative competence at the theoretical and practical levels. It has been studied out that Moodle platform helps to create an integrated learning environment with well-established interaction of all participants, to form the communicative competence of future graduates.
Keywords: competency approach; communicative competence; computer-oriented learning environment; Moodle platform; empathic relationships; dialogic educational model; teaching the “Philosophy” course; educational experience of KNUC&A.
ACTUAL ASPECTS OF THE DEVELOPMENT OF SOCIAL AND COMMUNICATIVE ACTIVITY OF STUDENTS
Authors: Averina Kateryna
Published: December 2021

The paper considers the procedural aspects of social communication such as meeting the requirements of today’s comprehensive characteristics of social skills of the future specialist, which is manifested in his ability and ability to effectively perform professional duties adequately to each situation by activating socially and professionally important qualities in the competent application of the existing arsenal of professional knowledge, skills and abilities. The semantic elements of social communication as forms of expression of will, practical actions of an individual or a social group in a certain collective activity to achieve a socially significant result are revealed. It is established that the level of development of social and communicative skills can characterize not only the mechanisms of acquiring knowledge, skills, professionally significant qualities in the learning process, but also the peculiarities of the students’ understanding of social reality in general and in specific situations in particular, when both the adaptive mechanisms and the integrated life narratives of the individual are significantly influenced by the characteristics of the social environment. The need for coordination and focus on creating appropriate conditions for attracting external and internal resources (as a set of objectively existing conditions, means, opportunities that can be mobilized and used in the process of development of any system) to address this issue, including the intensification of participation in the development of communication skills of leading agents of influence ‒ subjects of all levels and types of education – traditional, alternative, extracurricular, “non-formal”, etc.
Keywords: social communication; educational environment; communicative approach; social interaction; subjects of social communication; extracurricular activity; socialization skills; applicants of higher education.
USE OF COMPUTER TOOLS TO DEVELOP MOTIVATION OF STUDENTS TO STUDY MATHEMATICS: CRITERIA OF EFFICIENCY
Authors: Tabler Tetiana
Published: December 2021

The article considers the problem of development of cognitive activity of students in mathematics lessons. The peculiarities of the use of the formative system of assessment in the process of teaching mathematics with the use of computer tools in the context of the tasks of personality-oriented learning. The main risk factors for increasing the mathematical anxiety of students are identified. The pedagogical factors of motivation development and increase of interest in learning, development of mathematical thinking and reduction of mathematical anxiety due to the development of methods to increase the clarity of learning and cognitive activity of students related to the use of computer tools are substantiated. The criteria are substantiated and the indicators of assessment of the development of cognitive activity of students of 7‒9 grades of gymnasiums in the process of teaching mathematics with the use of computer tools are distinguished: motives of students learning at school; interest in studying the study of mathematics (algebra and geometry); success in the study of mathematics (algebra and geometry); motivation to study mathematical disciplines; mathematical anxiety. A method of assessing the impact of the use of computer tools to study certain topics and sections of mathematics in grades 7‒9 in general secondary education, which will increase the motivation of students to study the subject and reduce the level of mathematical anxiety of students. The results are presented and the dynamics of the indicators of the experimental influence of the use of computer interactive tools on the motivation of students to study mathematics is analyzed.
Keywords: personality-oriented learning; mathematical disciplines; mathematical anxiety; pedagogical conditions; mathematics teaching aids; motivation to study mathematics; interactive computer learning tools; success in the study of mathematics.
HISTORICAL ASPECT OF FORMATION AND DEVELOPMENT OF PARTNERSHIP PEDAGOGY
Authors: Tkachuk Larysa
Published: December 2021

In the article, the periodization of the formation and development of partnership pedagogy has been based on socio-pedagogical prerequisites, clarifying the contribution of prominent philosophers, educator-innovators in the development of theoretical, methodological, and technological aspects of partnership pedagogy. The author divides the formation and development of the pedagogy of partnership into two periods: the preparatory and the development of the ideas of partnership pedagogy.The chronological framework of the preparatory period – from antiquity (V century BC) to the 80s of the XX century has been determined. There are two stages within the preparatory period: the first stage – from antiquity (V century BC) to the 50s of the twentieth century, the second stage – the 50–80s of the twentieth century. It has been established that within the first stage, the studied phenomenon is not the object of purposeful holistic study it appeals to it are spontaneous and unsystematic, knowledge about it is scanty and contradictory. The second stage of the preparatory period (the '50s – the mid-'80s of the twentieth century) has been characterized by a systematic study of certain aspects of the problem, the emergence of theories and concepts of cooperation pedagogy, which in the future form the basis of partnership pedagogy, help determine its formation and development.The peculiarities of the second period of the partnership pedagogy development (from 1986 to the present) have been clarified. Two stages of this period are distinguished by the author: the first – from 1986 to 2016, the second – from 2016 to the present. The first stage begins with the signing by the teachers-innovators of the Manifesto “Pedagogy of Cooperation” (1986) and has been characterized by a thorough scientific study, design of ways and means of development of the cooperation pedagogy. Since 2016, when the Concept of the New Ukrainian School has been adopted, the second stage of the second period of formation of partnership pedagogy begins. The concept of “partnership pedagogy” has been transferred from the world view to the normative plane; research is actively carried out, and ideas of partnership pedagogy are developed.
Keywords: partnership pedagogy; cooperation pedagogy; philosophical thought; humanism; teachers-innovators; New Ukrainian School; periodization; formation and development.
PELATIHAN PENULISAN SURAT DINAS PADA PERANGKAT DESA/KELURAHAN DI KECAMATAN JAYALOKA KABUPATEN MUSI RAWAS
Authors: Astuti Tri , Dewi Rusmana , Muslihah Nur Nisai
Published: December 2021

Tujuan akhir kegiatan pelatihan ini adalah meningkatkan pemahaman dan kemampuan para perangkat desa/kelurahan tentang penulisan surat dinas yang baik dan benar berdasarkan aturan dan kaidah PUEBI. Pelaksanaan pelatihan selama dua hari, dari tanggal 31 Mei s.d. 1 Juni 2021 bertempat di ruang pertemuan Kecamatan Jayaloka. Metode yang digunakan ceramah, tanya jawab, disikusi, dan latihan. Sasaran pelatihan adalah para perangkat desa/kelurahan yang ada di Kecamatan Jayaloka Kabupaten Musi Rawas, berjumlah 13 orang. Temuan awal dari hasil analisis data dokumentasi surat masuk dari desa/kelurahan yang tersimpan di pengarsipan surat pada kantor Camat Kecamatan Jayaloka ditemukan masih banyak perangkat desa/kelurahan yang kurang dan belum memahami tata aturan penulisan surat dinas,  khususnya dalam penggunaan kaidah kebahasaan, seperti pemilihan diksi, penggunaan huruf kapital, penggunaan tanda baca, dan penulisan kata tugas. Umumnya para perangkat desa/kelurahan dalam membuat surat dinas hanya copy paste dari surat yang sudah ada. Setelah dilakukan pelatihan selama dua hari menunjukkan adanya peningkatan pengetahuan, pemahaman, dan kemampuan para perangkat desa/kelurahan yang ada di Kecamatan Jayaloka Kabupaten Musi Rawas dalam menulis surat dinas yang baik dan benar berdasarkan aturan dan kaidah PUEBI. Hal ini didukung dari respons peserta pelatihan menunjukkan respons yang cukup baik, ada 69,23% peserta tuntas menyelesaikan kegiatan pelatihan sampai penyelesaian tugas akhir/latihan.
PELATIHAN PEMBUATAN DAN PEMASARAN ZPT ALAMI DI KELURAHAN CAWANG BARU KECAMATAN SELUPU REJANG
Authors: Jayati Ria Dwi , Fitriyana Nur
Published: December 2021

Program Kemitraan Masyarakat (PKM) yang kami usulkan diharapkan dapat membantu masyarakat Kelurahan Cawang Baru pada umumnya dan kelompok IRT Adelia pada khususnya dalam pembuatan dan pemasaran Zat Perangsang Tumbuh (ZPT) alami. Kelurahan Cawang Baru yang terdapat di Kecamatan Selupu Rejang merupakan daerah pertanian yang banyak menghasilkan berbagai macam jenis komoditas tanaman pertanian. Disamping fakta tersebut, saat ini juga sedang marak sekali masyarakat penghobi bunga khususnya ibu-ibu. Selama ini petani dan juga para penghobi tanaman hias di Kelurahan Cawang baru dalam budidaya atau memperbanyak tanaman selain menggunakan pupuk juga menggunakan ZPT yang dijual di pasaran, harga ZPT pabrikan di pasaraan lumayan mahal dan sedikit sulit didapatkan di toko-toko pertanian konvensional karena kandungannya yang tidak alami bisa saja memberikan efek buruk terhadap lingkungan. Mengingat biaya yang harus dikeluarkan untuk membeli ZPT kimiawi dan dampak buruknya terhadap lingkungan, membuat ZPT sendiri dengan memanfaatkan bahan alami yang ada di sekitar menjadi solusi yang tepat untuk menangani masalah biaya dan dampak lingkungan. Untuk mencapai tujuan tersebut, kami menggunakan metode observasi, sosialisasi, pelatihan dan dilanjutkan dengan praktek langsung. Tujuan jangka panjang kegiatan ini adalah menciptakan peluang usaha bagi kelompok PKK Adelia dengan memanfaatkan bahan alami sebagai ZPT yang keberadaannya dibutuhkan petani dan penghobi tanaman hias. Target luaran dari kegiatan adalah (1) pengetahuan, keterampilan dan penghasilan mitra meningkat, (2) menghasilkan produk ZPT alami. Target luaran publikasi: hasil pengabdian dipublikasikan pada jurnal pengabdian masyarakat.
Robustness of Maximin Space-filling Designs
Authors: Lisitza Cassandra
Published: December 2021

In this report, we first have a review of the maximin space-filling design methods that is often applied and discussed in the literature (for example, Müller (2007)). Then we will discuss the robustness of the maximin space-filling design against model misspecification via numerical simulation. For this purpose, we will generate spatial data sets on a n x n grid and design points are selected from the n2 locations. The predictions at the unsampled locations are made based on the observations at these design points. Then the mean of the squared prediction errors are estimated as a measure of the robustness of the designs against possible model misspecification. Surprisingly, according to the simulation results, we find that the maximin space-filling designs may be robust against possible model misspecification in the sense that the mean of the squared prediction error does not increase significantly when the model is misspecified. Although the results were obtained based on simple models, this result is very inspiring. It will guide further numerical and theoretical studies which will be done as future work.
Comparison of Treatment Outcomes between Right- and Left-sided Colorectal Adenocarcinoma after Adjuvant Chemotherapy
Authors: Pizarro Dean Marvin Potato , Dy Carlos , Ordinario Mel Valerie` Cruz- , Atutubo Cyrielle Marie
Published: December 2021

Objective: The survival outcomes of patients with metastatic colorectal adenocarcinoma based on tumor laterality has already been established based on large-scale retrospective studies. As for the non-metastatic disease, the data is much more conflicting. Local data in this population is also scarce. In this study, we determined the difference in survival of right-sided versus left-sided colorectal cancer patients after surgery and adjuvant chemotherapy. Patients and Methods: This retrospective study analyzed a total of 124 patients who were diagnosed with early to locally advanced (stage I to IVA) colorectal adenocarcinoma and underwent definitive surgery and adjuvant systemic treatment per physician’s preference. The patients were stratified according to the primary tumor laterality: Right-Sided Colon cancer (RCC) and Left-sided Colon cancer (LCC). The primary outcome being investigated is the disease-free survival (DFS) at 3 years and 5 years. Secondary outcomes are overall survival (OS) at 3 years and 5 years, and site of disease recurrence across laterality.Results: The findings did not show a significant difference in the 3-year and 5-year DFS between RCC and LCC after surgery and adjuvant chemotherapy (3-year DFS: 50.0% in the RCC group and 54.3% in the LCC group; P=.671; 5-year DFS: 36.7% in the RCC group and 36.2% in the LCC group, P=.474). The OS difference was also not significant at 3 years and 5 years (3-year OS: 68.8% in the RCC group and 73.9% in the LCC group, P=.572; 5-year OS: 31.3% in the RCC group and 26.1% in the LCC group, P=.474). The overall recurrence rate was not significantly different in both groups (65.6% in the RCC group and 66.3% in the LCC group; P=.944). Majority of the recurrences were at a distant site in both groups (61.1% in the RCC group and 69.6% in the LCC group; P=.501) and the most common were in the lungs, and liver. Conclusion: The survival outcome of non-metastatic colorectal adenocarcinoma was not significantly different between RCC and LCC after surgery and adjuvant chemotherapy. The outcome was also similar after stratification of the population into early and locally advanced disease. More diverse clinical characteristics other than tumor location may be prognostic of disease-free and survival outcomes in the non-metastatic setting of colorectal cancer. Further studies with a larger sample size are needed to validate the correlation of survival to the specific stage and anatomic location.
The Role of Immunohistochemistry in the Workup of Malignant Neoplasms of Unknown Primary Origin at Khartoum Oncology Hospital
Authors: O.R Omar Eiman , Haussein Naik , Ahmed Amal
Published: December 2021

Background: Carcinoma of unknown primary origin (CUP) comprises various malignancies classified by detection of tissue-specific genes through immunohistochemistry (IHC). We aimed to explore the role of available immunohistochemical markers in diagnosing and classifying malignant neoplasms of unknown primary origin.Methods: A cross-sectional study included 141 patients diagnosed histologically as CUP and referred to the Histopathology and Immunohistochemistry Department, Khartoum Oncology Hospital, from 2012 to 2017. Hematoxylin and Eosin (H&E) and immune stained slides used in the workup were reviewed and classified into the main histologic types of CUP. Data were -analyzed by SPSS. Results: Out of 4436 cases, CUP represents (3.2%). The age group (60-69) years have the highest percentage (20.13%), with male predominance (51.77%). Lymph nodes represent (41.84%) followed by the liver (12.77%), spine (3.55%), and lungs (2.13%). Adenocarcinoma (75.89%) was the most common subtype, followed by undifferentiated neoplasm (14.18%), squamous cell carcinoma (7.09%), and carcinoma with neuroendocrine differentiation (2.84%). In 70 cases (49.6%) of the study cases, the primary site was determined, (17.7%) were given an only differential diagnosis, and in (32.6%) the origin remains unknown. Conclusions: CUP cases during the study period are infrequent (3.2%), and the primary origin was determined in nearly half of patients by the available immune markers. CUP’s common histological types were adenocarcinoma, undifferentiated neoplasm, squamous cell carcinoma, and carcinoma with neuroendocrine differentiation. The most common presenting sites were lymph node, liver, spine, and lungs.
Real World Data of Response of Trastuzumab Based Chemotherapy in Locally Advanced HER2 Positive Breast Cancer from a Developing Country
Authors: Chandra Doval Dinesh , Bothra Sneha , Goyal Pankaj , Agrawal Chaturbhuj , Jain Parveen , Tripathi Rupal , Sharma Anurag , Pasricha Sunil , Choudhary Kumardeep  Dutta
Published: December 2021

Background: Data regarding pathologic response of Trastuzumab based chemotherapy in locally advanced HER2 positive breast cancer in neoadjuvant setting is scarce. Methods: A retrospective analysis was conducted from January 2014 to January 2019 at a tertiary cancer care centre in North India and 81 breast cancer patients who underwent neoadjuvant chemotherapy were included. The clinical and pathologic characteristics, response, toxicity and survival data was collected, collated and analyzed. Results: The most commonly observed tumor characteristics at baseline were clinical stage T4 (72.8%), nodal stage N2 (40.7%), invasive ductal carcinoma on histology (98.8%), grade 3 (66.7%) and hormone receptor negativity (54.3%). In terms of post treatment characteristics, a higher incidence of partial response (55.6%), post treatment tumor stage ypT0 (45.7%), nodal status ypN0 (54.3%), absence of extracapsular invasion (77.8%) and absence of pathologic complete response (pCR, 63%) were observed. pCR was attained in 30 patients and was most commonly associated with clinical tumor stage T4 (26/30), nodal stage N2-N3 (19/30), grade 3 (21/30) and hormone receptor negativity (20/30). Altogether, 19.75% had grade 3/4 adverse events. At 6 years, 86% v/s 61% patients were disease free (p=0.037) and 93% v/s 79% patients (p=0.181) were alive in the pCR and no pCR groups, respectively. Conclusion: Even in locally advanced breast cancer (LABC), Trastuzumab had good response in terms of pCR and survival outcomes. Thus, one can be encouraged to use this single HER2 blockade if dual blockade is not feasible in HER2 positive LABC in the neoadjuvant setting.
Ovarian Germ Cell Tumor with Myasthenia Gravis: Co-incidence or a Possible link?
Authors: Iftikhar Jhanzeb , Sheikh Fareeha , Khalid Nazish , Sarwar Muhammad Abubakar , Azhar Musa , Masood Sheikh Rizwan
Published: December 2021

Teratomas are a common form of germ cell tumor. Teratomas are commonly found in the gonadal organs, such as the ovaries and testes. Treatment of choice for ovarian teratomas is complete surgical excision, which exhibits a good prognosis in benign teratomas; however, chemotherapy treatment is needed for malignant components. Neurological paraneoplastic presentation of gynecological tumors is rare; however, ovarian tumors account for 10% of this presentation. In literature, paraneoplastic limbic encephalitis, anti-N-methyl-D-aspartate receptor encephalitis, and paraneoplastic cerebellar degeneration have been reported in ovarian teratomas and tumors; however, myasthenia gravis has been reported only twice. In both of those cases, manifestation of myasthenia gravis was preceding the diagnosis of ovarian cancer. We describe the first case of a 21-year-old female who presented with new-onset myasthenia gravis after finishing chemotherapy for ovarian teratoma. Another unusual aspect of our case is the rare co-occurrence of gliomatosis peritonei with mature teratoma.
Refractory Craniopharyngioma: Successful Treatment with LINAC Based Stereotactic Radiosurgery (SRS): First Case in Nepal
Authors: Thakur Subhash , Chawla Saloni
Published: December 2021

Purpose: To present first case of refractory craniopharyngioma treated successfully with SRS in Nepal. Bckground: Craniopharyngioma is a benign tumour, which progresses slowly and compresses the pituitary gland and nearby structures. First line of treatment is surgery followed by adjuvant radiotherapy as complete resection is usually not feasible. Here, we are reporting a case of recurrent craniopharyngioma treated with LINAC based SRS. Case Presentation: A 43 years old man diagnosed case of craniopharyngioma in May 2019. He underwent left pterional craniotomy and subtotal resection of tumour and kept on observation. He developed symptomatic as well as radiological recurrence in July 2020. Second debulking was not possible, so we did SRS on 23rd August 2020; 14Gy Dose was delivered to gross tumour volume. Six months after SRS, Patient is doing well. Conclusions: LINAC based SRS is a frameless, non-invasive and safe procedure with excellent clinical outcomes for recurrent or residual craniopharyngioma.
Strategic and Economic Importance of Chabahar Port
Authors: Munir Fakhr ul , khan Shaukat , Ihsan Nelofer
Published: December 2021

Due to China's engagement in the Gwadar Port,India has hastened the process of becoming ashareholder and stakeholder in Chabahar Port in order tocounter the Chinese threat. Chabahar is India's gateway toCentral and South Asia. It is Iran's intention to link and accessthese countries through the building of the Chabahar Port. Withthe expansion of these connections between South Asia andCentral Asia, West Asian countries and Europe via Chabahar,not only will Iran gain, but so will the nations of these regions.Iran will be able to play a key role as a result of these linkages,which will increase the strategic importance of Iran andChabahar.
Postmodern Absurdist Critique of Julian Barnes’s The Only Story
Authors: Nawaz Arshad , Ijaz Muhammad , Anjum Khalid Mehmood
Published: December 2021

This research paper endeavors to examine the postmodern absurdism as a literary sub genre in postmodern fiction. It delves deep into the concept of absurdism by concentrating upon the characteristics that distinguish it as a postmodern sub genre. Through the analysis of the postmodern novel, The Only Story (2018), this research paper illustrates how the characteristics of absurdism haven impact upon a postmodern society characterized by boredom, meaninglessness, futility, and confusion. It also highlights how different characters, events, and places have been portrayed in the novel to depict the absurdity of human existence. The theoretical paradigm of the research is based upon Thomas Nagel’s Essay “The Absurd” which is about postmodern space of absurdism and was presented in the American Philosophical Association Eastern Division. The study limelight's how the absurd occurrences and bizarre characters found in the researcher's primary text depict the complexity of the postmodern absurd world in both literal and metaphoric dimensions.
Study of Lexical Variation between Dhani and Majhi Punjabi
Authors: Hasan Wasim , Khan Arshad Ali
Published: December 2021

Abstract The present study highlights lexical variation in Dhani and Majhi dialects of Punjabi language spoken in Pakistani Punjab that may lead to a communication gap. It focuses on the description of vocabulary differences of words of daily use. It is partly qualitative and partly quantitative research, which was conducted through a survey. Data were collected from thirty participants (15 speakers from each variety) from Chakwal district of Rawalpindi Division and Sheikhupura, Nankana Sahib districts of Lahore Division in Punjab province, Pakistan. It was collected through a word list consisting of two hundred and sixty vocabulary items that are used in daily conversation. Results retrieved from analysis of the collected data show that two hundred and nine Dhani words, i-e 80 %, do not exist in Majhi variety at all and have their alternatives in Majhi whereas, fifty-one words i-e 20 % exist but are pronounced differently in Majhi.
The Use of Technological Gadgets by English Language Students: A Study at University Level in Southern Punjab Pakistan
Authors: Khaliq Abdul , Raes Muhammad , Ahmad Rasheed
Published: December 2021

Using technological gadgets for the learning process is now important. Information technology playsan important role in the study of English as a foreign language. The current study determines theadvantages and ease of use of technological devices offered by South Punjab Universities as teachingaids. The study also looked at student fulfillment and emphasized the difficulties met by English-speaking pupils in using these means. It was a blended technique study in which a survey was appliedto collect the data. Members were 170 male and female understudies from the Faculty of English andTranslation Studies. The discoveries show that technical gadgets are exceptionally helpful and adaptableto utilize. The understudies were happy with the innovative hardware. Unexpectedly, a few understudiesannounced encountering various issues, like web issues, absence of abilities, and absence of directionprograms. Ends and suggestions on the utilization of these assets are given.
Anarchism: A Legacy of Postmodernism
Authors: Shaukat  , Munir Fakhr ul , Hamza Muhammad
Published: December 2021

This study has made the implicit links betweenpostmodernism and anarchism explicit in order to uncoverthe philosophical origins of terrorism in the postmodern society. This studydeals with the Anarchists' philosophical background and howPostmodernism fanned it. Anarchists' approach mainly whirls around asingle point agenda, and that is, they are against the state or existence ofstates' borders. I mention again what Researcher has already mentioned,the state and all other international institutions emerged after a rationalapproach as stated by Hegel. Postmodernism denied that reality in everycontour, whether those are institutions or anything else. Anarchism broughtthis concept into a broader paradigm and started denying the existence ofthe state. So, both postmodernists and anarchists have denied the realityin their own capacities, but the grounds and arguments are the same.Anarchism paved the way for multiple active terrors based centrifugalmovements throughout the world.
Covid-19 information from the three most widely read newspapers in Europe. Differences and convergences
Authors: Strizzolo Nicola , Moschin Massimiliano
Published: December 2021

Our study aims to understand the mutability of virus-related discourses by tracing common points of reference. To do so, we chose three newspapers from as many European states and monitored each mid-month Wednesday during the first wave of Covid-19: January to October 2020. The newspapers investigated were those with the largest audience: Corriere della Sera (Italy), Das Bild (Germany), and The Sun (United Kingdom). To do so, we used categories such as context, frame, and theme. We sifted the corpus, comprising 1175 articles, with Atlas.ti. Based on the categories used and their frequency, we reconstructed contextualization, framing, and thematization – all at a more abstract level. On content revolving around the keywords Covid-19 and Coronavirus, the only differences that emerged were a greater interest in sports for The Sun and vacations for Das Bild. All the newspapers considered granting little space to the weakest areas of the population: disabled or young people, women, immigrants, and the unemployed.
Kapitał społeczny elementem konstytutywnym bezpieczeństwa publicznego
Authors: Adamczyk Monika
Published: December 2021

Szukając nowych rozwiązań dla starych problemów, zwraca się uwagę na takie znaczące dla dobrego funkcjonowania współczesnego społeczeństwa kwestie jak sieci powiązań międzyludzkich, zaufanie czy normy. Pojęcie kapitału społecznego jest używane już od kilku dekad do opisu i wyjaśniania fenomenu zmian w sferze społeczno-politycznej i gospodarczej, zaistniałych w wyniku transformacji społeczno-ekonomicznej. Odnosi się ono również do sfery działań obejmujących m.in. budowanie partnerskich i demokratycznych relacji we wspólnotach lokalnych, w których kapitał społeczny stanowi podstawę trwałych sieci społecznego zaangażowania zaufania i wzajemności. Celem prezentowanego artykułu jest próba przedstawienia korzyści wynikających z posiadania przez wspólnotę lokalną zasobów kapitału społecznego, jak również wskazanie jego pozytywnego oddziaływania na bezpieczeństwo publiczne.
Studies and Analyses of Political Science
Authors: Makuch Anna
Published: December 2021

Research goal of the article has been set to verify the hypothesis according to which technological innovations contribute to systemic safety during the COVID-19 pandemic. The analyzed area contains key statements of available data regarding innovation impulses in the first pandemic period (2020 – spring/autumn). In the light of this data new trend has been confirmed to be using advanced technologies based on digital records in promoted solutions. Innovation in pandemic days meets conditions, not by classic definitions of the term “innovation” but rather “ultra-fast-innovation” which creatively uses digitalized tools. Technological innovations fulfill their role of aiding the safety process under the conditions which assume that network-based storage and data transfer systems are reliable and resistant against systemic crisis, which is a potential systemic threat.
ANALISIS STRATEGI PENGEMBANGAN PEMASARAN PRODUK SARI KURMA CV. AMAL MULIA SEJAHTERA, KABUPATEN BOGOR
Authors: Putra Aditya Perdana , Budiraharjo Kustopo , Mukson Mukson
Published: December 2021

Penelitian ini bertujuan untuk mengidentifikasi dan menganalisis faktor-faktor internal dan faktor-faktor eksternal pemasaran produk sari kurma, merumuskan alternatif strategi pemasaran yang dapat diterapkan terhadap produk sari kurma, dan menyusun prioritas alternatif strategi pemasaran terhadap produk sari kurma di CV. Amal Mulia Sejahtera. Penelitian ini dilaksanakan pada bulan Februari – April 2021 di CV. Amal Mulia Sejahtera, Kabupaten Bogor. Metode penentuan sampel yang digunakan merupakan teknik judgement sampling dengan total 8 orang responden. Data dianalisis secara deskriptif kuantitatif menggunakan metode analisis Strength, Weakness, Opportunity, and Threat (SWOT) dan Analytical Hierarchy Process (AHP). Hasil penelitian menunjukkan bahwa prioritas alternatif strategi yang dapat direkomendasikan untuk diterapkan terhadap pemasaran produk sari kurma Al-Jazira milik CV. Amal Mulia Sejahtera secara berurutan, yaitu: (1) Memperluas jangkauan distribusi dan penjualan produk sari kurma, (2) Peningkatan kualitas dan kuantitas produk sari kurma, (3) Optimalisasi promosi produk sari kurma dalam peningkatan pangsa pasar, dan (4) Memelihara stabilitas harga produk sari kurma. Prioritas substrategi utama yaitu “Meningkatkan jumlah dan persebaran agen produk sari kurma CV. Amal Mulia Sejahtera di berbagai wilayah di Indonesia”.
Characteristics of patients who dropped out after multidisciplinary pain management in Japan: A prospective cohort study
Authors: Takahashi Naoto , Takatsuki Kozue , Kasahara Satoshi , Yabuki Shoji
Published: December 2021

BACKGROUND: Because regular visits to distant hospitals may be a burden to patients, both in terms of time and cost, some patients with chronic musculoskeletal pain may discontinue multidisciplinary pain treatment, unable to maintain motivation to attend. OBJECTIVE: To evaluate and compare the pre-program characteristics of patients who dropped out and patients who continued treatment, thereby clarifying the characteristics of patients at risk of dropping out. METHODS: A multidisciplinary pain management treatment program was implemented for patients at the Pain Management Center, Hoshi General Hospital. From April 2015 to March 2018, 23 patients participated in the program. Twelve of the 23 patients lived outside the prefecture where the hospital is located. Of these 12 patients, five completed the program, while seven did not. We compared the dropout and continuation groups in terms of patient characteristics, pain severity, pain-related psychosocial factors, and quality of life. RESULTS: We found significant differences (p< 0.05) in median age, Japanese Orthopaedic Association Back Pain Evaluation Questionnaire walking ability dysfunction score, and Roland-Morris Disability Questionnaire score. CONCLUSIONS: The characteristics of patients who dropped out were older age, walking ability dysfunction, and low quality of life associated with low back pain.
Long noncoding RNA RP11-909N17.2 presages a poor prognosis of non-small cell lung cancer
Authors: Gao Wei , Liu Tingting , Tuo Zhongzhen , Ma Lujuan , Zhou Zehua
Published: December 2021

BACKGROUND: Long non-coding RNAs (lncRNAs) were detected extraordinarily expressed in various tumors and could combine with microRNAs (miRNAs) to play important role in tumor cells. This study is to explore the role of lncRNA RP11-909N17.2 in NSCLC and discuss in what way it functions in NSCLC. METHODS: 120 NSCLC patients were enlisted in this study. Expression levels of lncRNA RP11-909N17.2 and miR-767-3p were detected and the correlation between lncRNA RP11-909N17.2 expression and the clinical data characteristics was analyzed. Prognosis potential of lncRNA RP11-909N17.2 was inferred with Kaplan-Meier and multivariate Cox regression assays. Biological functions of NSCLC cells were accessed by cell counting Kit-8, transwell migration and invasion assay. Mechanism of RP11-909N17.2 action on NSCLC cells was investigated by luciferase activity assay with wide-type or mutation. RESULTS: LncRNA RP11-909N17.2 has an ascendant expression while miR-767-3p has descended one in NSCLC tissue specimens and cells. Over-expression of lncRNA RP11-909N17.2 can shorten the overall survival period of NSCLC patients when compared with low expression. Knockdown of lncRNA RP11-909N17.2 suppressed biology function of NSCLC cell including proliferation, migration, and invasion. CONCLUSION: LncRNA RP11-909N17.2 can be developed into a prognostic index for NSCLC. LncRNA RP11-909N17.2 plays a promoting role in NSCLC cells possibly by binding miR-767-3p as a sponge.
Methylation of FBN1, SPG20, ITF2, RUNX3, SNCA, MLH1, and SEPT9 genes in circulating cell-free DNA as biomarkers of colorectal cancer
Authors: Alizadeh-Sedigh Maryam , Fazeli Mohammad Sadegh , Mahmoodzadeh Habibollah , Sharif Shahin Behrouz , Teimoori-Toolabi Ladan
Published: December 2021

BACKGROUND: Investigating aberrant tumor-specific methylation in plasma cell-free DNA provides a promising and noninvasive biomarker for cancer detection. OBJECTIVE: We aimed to investigate methylation status of some promoter regions in the plasma and tumor tissues to find biomarkers for early detection of colorectal cancer. METHODS: This case-control study on seventy colorectal cancer patients and fifty matched healthy controls used Methylation-Specific High-Resolution Melting Curve analysis to evaluate the methylation of the selected promoter regions in converted genomic tissue DNA and plasma cfDNA. RESULTS: The methylation levels in selected regions of SPG20 (+24375 to +24680, +24209 to +24399, and +23625 to +23883), SNCA (+807 to +1013, +7 to +162, and -180 to +7), FBN1 (+223 to +429, +1 to +245, and -18 to -175), ITF2 (+296 to +436 and -180 to +55), SEPT9 (-914412 to -91590 and -99083 to -92264), and MLH1 (-13 to +22) were significantly higher in tumor tissues compared with normal adjacent tissues. The methylation levels of FBN1, ITF2, SNCA, and SPG20 promoters were significantly higher in the patient’s plasma compared to patient’s normal tissue and plasma of healthy control subjects. FBN1, SPG20, and SEPT9 promoter methylation had a good diagnostic performance for discriminating CRC tissues from normal adjacent tissues (AUC > 0.8). A panel of SPG20, FBN1, and SEPT9 methylation had a higher diagnostic value than that of any single biomarker and other panels in tissue-based assay (AUC > 0.9). The methylation of FBN1(a) and SPG20(a) regions, as the closest region to the first coding sequence (CDS), had a good diagnostic performance in plasma cfDNA (AUC > 0.8) while a panel consisted of FBN1(a) and SPG20(a) regions showed excellent diagnostic performance for CRC detection in plasma cfDNA (AUC > 0.9). CONCLUSION: Methylation of FBN1(a) and SPG20(a) promoter regions in the plasma cfDNA can be an excellent simple, non-invasive blood-based test for early detection of CRC.
Anti-inflammatory iron chelator, DIBI, reduces leukocyte-endothelial adhesion and clinical symptoms of LPS-induced interstitial cystitis in mice
Authors: Hagn Georg , Holbein Bruce , Zhou Juan , Lehmann Christian
Published: December 2021

BACKGROUND: Interstitial cystitis (IC) is a prevalent and debilitating chronic inflammatory disease of the urinary bladder. Currently there are no fully effective therapeutic agents available, in part due to the still obscure pathogenesis of IC. Lipopolysaccharide (LPS) also known as endotoxin from Gram negative bacteria elicits IC in mice and has formed the basis of model systems for investigation. Excess free iron plays an important role in inflammation through generation of reactive oxygen species (ROS). The novel iron chelator DIBI has been shown to sequester excess free iron and dampen excess inflammatory responses to systemic LPS administration and also to Gram negative bacterial infections. OBJECTIVE: The overall objective of this study was to evaluate the effects of DIBI on LPS induced IC in mice. Leukocyte activation, endothelial adhesion and functional capillary density were assessed by intravital microscopy of the bladder microcirculation following a single intravesical LPS administration with or without intravesical DIBI treatment. Clinical IC symptoms were also assessed through behavioral and pain threshold force measurements. METHODS: Four groups of female BALB/c mice (n = 5–6/group) were randomized in this study: control group, IC group without therapy, IC group with DIBI therapy and control group with DIBI therapy. The groups were examined using intravital microscopy (IVM) of the bladder for leukocyte-endothelial interactions (adherent leukocytes, temporarily interacting leukocytes) and functional capillary density (FCD). A modified behavioral score by Boucher et al. and Von-Frey-Aesthesiometry were used to evaluate key behavioral indices related to pain and visceral pain perception. RESULTS: LPS introduced intravesically induced an early (≤2h) inflammation of the bladder evidenced by leukocyte activation and adhesion to bladder capillary walls. Intravesical DIBI therapy of mice 30min following LPS administration and assessed after 1.5h treatment showed a significant decrease in the number of adherent leukocytes compared to IC animals without DIBI treatment. DIBI treated mice showed a significantly lowered increase in behavioral distress scores compared to IC mice without therapy. Untreated IC mice exhibited a significantly decreased threshold force value for evoked pain response and DIBI treatment improved the threshold pain response. A significant inverse correlation was found for the two pain and suffering evaluation methods results. CONCLUSION: DIBI reduced inflammatory endothelial leukocyte adhesion and key indices related to pain and suffering over those observed in untreated IC mice. Our findings suggest a potential therapeutic role for DIBI for IC treatment.
The provincial trend of population aging in China – based on population expansion forecast formula
Authors: Duan Lingyun , Liu Ziyuan , Yu Wen , Chen Wei , Jin Dongyan , Feng Yao , Wang Yu , Liu Jiajia , Zhou Han , Sun Suhua , Dai Ruixi
Published: December 2021

China is one of the countries that have entered the stage of population aging. At present, the phenomenon of aging population has become a widespread concern of the whole society. Scientific and accurate prediction of aging population will help relevant departments to formulate specific countermeasures. This paper uses the Yearbook of China’s 1% population sampling survey in 2015 and the data published by the National Bureau of statistics. Based on the basic population prediction formula, the population prediction formula is established by using the index extrapolation method to predict the population aging development trend of provinces and cities in China from 2020 to 2050. The results show that: China’s aging degree will continue to increase, the size of the elderly population will continue to increase, 2020–2030 will be a period of rapid growth of the national population aging, after then the aging ratio will decline. The government should formulate security countermeasures for the elderly from various aspects as soon as possible and actively respond to aging the population.
Attention Deeplabv3 model and its application into gear pitting measurement
Authors: Xi Dejun , Qin Yi , Wang Zhiwen
Published: December 2021

An efficient visual detection method is explored in this study to address the low accuracy and efficiency of manual detection for irregular gear pitting. The results of gear pitting detection are enhanced by embedding two attention modules into Deeplabv3 + to obtain an improved segmentation model called attention Deeplabv3. The attention mechanism of the proposed model endows the latter with an enhanced ability for feature representation of small and irregular objects and effectively improves the segmentation performance of Deeplabv3. The segmentation ability of attention Deeplabv3+ is verified by comparing its performance with those of other typical segmentation networks using two public datasets, namely, Cityscapes and Voc2012. The proposed model is subsequently applied to segment gear pitting and tooth surfaces simultaneously, and the pitting area ratio is calculated. Experimental results show that attention Deeplabv3 has higher segmentation performance and measurement accuracy compared with the existing classical models under the same computing speed. Thus, the proposed model is suitable for measuring various gear pittings.
Using a recurrent neural network with S2 characteristics, efficient identification of localised cortical dysplasia
Authors: Karthika A. , Subramanian R. , Karthik S.
Published: December 2021

Focal cortical dysplasia (FCD) is an inborn anomaly in brain growth and morphological deformation in lesions of the brain which induces focal seizures. Neurosurgical therapies were performed for the detection of FCD. Furthermore, it can be overcome through the presurgical evaluation of epilepsy. The surgical result is attained basically through the output of the presurgical output. In preprocessing the process of increasing true positives with the decrease in false negatives occurs which results in an effective outcome. MRI (Magnetic Resonance Imaging) outputs are efficient to predict the FCD lesions through T1- MPRAGE and T2- FLAIR efficient output can be obtained. In our proposed work we extract the S2 features through the testing of T1, T2 images. Using RNN-LSTM (Recurrent neural network-Long short-term memory) test images were trained and the FCD lesions were segmented. The output of our work is compared with the proposed work yields better results compared to the existing system such as artificial neural network (ANN), support vector machine (SVM), and convolution neural network (CNN). This approach obtained an accuracy rate of 0.195% (ANN), 0.20% (SVM), 0.14% (CNN), specificity rate of 0.23% (ANN), 0.15% (SVM), 0.13% (CNN) and sensitivity rate of 0.22% (ANN), 0.14% (SVM), 0.08% (CNN) respectively in comparison with RNN-LSTM.
Deep symbolic processing of human-performed musical sequences
Authors: Rangel Nahum , Godoy-Calderon Salvador , Calvo Hiram
Published: December 2021

Artificial music tutors are needed for assisting a performer during his/her practice time whenever a human tutor is not available. But for these artificial tutors to be intelligent and fulfill the role of a music tutor, they have to be able to identify errors made by the performer while playing a musical sequence. This task is not a trivial one, since all musical activities are considered as open-ended domains. Therefore, not only there is no unique correct way of performing a musical sequence, but also the analysis made by the tutor has to consider the development level of the performer, the difficulty level of the performed musical sequence, and many other variables. This paper describes an ongoing research that uses cascading connected layers of symbolic processing as the core of a human-performed error identification and characterization module able to overcome the complexity of the studied open-ended domain.
Factors predicting fear of falling avoidance behavior in parkinsonisms
Authors: Longhurst Jason K. , Rider John V. , Eckard Kameron , Hammar Ryan , Vukojevic Franjo , Campbell Jillian , Landers Merrill R.
Published: December 2021

BACKGROUND: Fear of falling avoidance behavior (FFAB) is common in parkinsonisms and results in potentially mitigable downstream consequences. OBJECTIVE: Determine the characteristics of individuals with parkinsonisms most associated with FFAB. METHODS: A retrospective, cross-sectional study was conducted from medical records data of 142 patients with parkinsonisms. These data included: demographics (age, sex), disease severity (Movement Disorders Society –Unified Parkinson’s Disease Rating Scale Part III (MDS-UPDRS III), years since diagnosis), fall history (number of fall injuries in previous year), and gait and balance function (five times sit to stand, MiniBESTest, Timed Up and Go (TUG), dual-task TUG, ten-meter walk test (10MWT), observed freezing of gait (FOG) (MDS-UPDRS III item 11)). RESULTS: 10MWT (p < .001) and MDS-UPDRS III item 11 (p < .014) were significantly associated with FFAB above and beyond disease severity, which also contributed significantly to the overall model (ps < .046). Fall history was not associated with FFAB. CONCLUSION: Our findings suggest that the largest portion of variability in FFAB is explained by gait velocity and FOG; however, disease severity also explains a significant portion of the variability of FFAB. Further investigation into factors predictive of FFAB and mitigation of downstream consequences, using more robust designs, is warranted.