bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictive Processing and Some Disillusions about Illusions
Authors: Gallagher Shaun , Hutto Daniel , Hipólito Inês
Published: November 2021

A number of perceptual (exteroceptive and proprioceptive) illusions present problems for predictive processing accounts. In this chapter we’ll review explanations of the Müller-Lyer Illusion (MLI), the Rubber Hand Illusion (RHI) and the Alien Hand Illusion (AHI) based on the idea of Prediction Error Minimization (PEM), and show why they fail. In spite of the relatively open communicative processes which, on many accounts, are posited between hierarchical levels of the cognitive system in order to facilitate the minimization of prediction errors, perceptual illusions seemingly allow prediction errors to rule. Even if, at the top, we have reliable and secure knowledge that the lines in the MLI are equal, or that the rubber hand in the RHI is not our hand, the system seems unable to correct for sensory errors that form the illusion. We argue that the standard PEM explanation based on a short-circuiting principle doesn’t work. This is the idea that where there are general statistical regularities in the environment there is a kind of short circuiting such that relevant priors are relegated to lower-level processing so that information from higher levels is not exchanged (Ogilvie and Carruthers, Review of Philosophy and Psychology 7:721–742, 2016), or is not as precise as it should be (Hohwy, The Predictive Mind, Oxford University Press, Oxford, 2013). Such solutions (without convincing explanation) violate the idea of open communication and/or they over-discount the reliable and secure knowledge that is in the system. We propose an alternative, 4E (embodied, embedded, extended, enactive) solution. We argue that PEM fails to take into account the ‘structural resistance’ introduced by material and cultural factors in the broader cognitive system.
A mathematical model for estimating effective stimulated reservoir volume
Authors: Ibrahim Adamu Umar , Negash Berihun Mamo , Rahman Md. Tauhidur , Suleiman Akilu , Kwaku Danso David
Published: November 2021

This study presents a model application for the evaluation of Effective Stimulated Reservoir Volume (ESRV) in shale gas reservoirs. This current model is faster, cheaper, and readily available for estimating ESRV compared to previously published models. Key controlling parameters for efficient ESRV modeling, including geomechanical parameters and time, are considered for the model development. The model was validated for both single and multi-stage fractured reservoirs. For the single fractured reservoir, an ESRV of 3.07 × 106 ft3 was estimated against 3.99 × 106 ft3 of ESRV-FEM field data. Whereas, 7.00 × 109 ft3 ESRV was estimated from the multi-stage fractured reservoir against 7.90 × 109 ft3 of fractal-based model results. Stress dependence, time dependence, and permeability dependence of shale gas reservoirs are found to be essential parameters for the successful calculation of ESRV in reservoirs. An ESRV determined using this method can obtain the estimated ultimate recovery, propped volume, optimal fracture length, and spacing in fractured shale gas reservoirs.
New correlations for predicting two-phase electrical submersible pump performance under downhole conditions using field data
Authors: Chu Thuy , Nguyen Tan C. , Wang Jihoon , Vuong Duc
Published: November 2021

Electrical Submersible Pump (ESP) is one of the major Artificial Lift methods that is reliable and effective for pumping high volume of fluids from wellbores. However, ESP is not recommended for applications with high gas liquid ratio. The presence of free gas inside the pump causes pump performance degradation which may lead to problems or even failure during operations. Thus, it is important to investigate effect of free gas on ESP performance under downhole conditions. At present, existing models or correlations are based on/verified with experimental data. This study is one of the first attempts to develop correlations for predicting two-phase gas–liquid pump performance under downhole conditions by using field data and laboratory data. Field data from three oil producing wells provided by Strata Production Company and Perdure Petroleum LLC. as well as experimental data obtained from experimental facility at Production and Drilling Research Project—New Mexico Tech were used in this study. Actual two-phase pump differential pressure per stage is obtained from experiments or estimated from field data and was normalized using pump performance curve. The values are compared to pump performance curve to study the relationships between pump performance and free gas percentage at pump intake. Correlations to predict ESP performance in two-phase flow under downhole and experimental conditions was derived from the results using regression technique. The correlation developed from field data presented in this study can be used to predict two-phase ESP performance under downhole conditions and under high gas fraction. The results from the experimental data confirm the reliability of the developed correlation using field data to predict two-phase ESP performance under downhole conditions. The developed correlation using the laboratory data predicts quite well the two-phase pump performance at the gas fraction of less than 15% while it is no longer reliable when free gas fraction is more than 15%. The findings from this study will help operating companies as well as ESP manufacturers to operate ESPs within the recommended range under downhole conditions. However, it is recommended to use the proposed correlation on reservoirs with conditions similar to those of the three presented wells.
Biological Equivalence of GGTA-1 Glycosyltransferase Knockout and Standard Porcine Pericardial Tissue Using 90-Day Mitral Valve Implantation in Adolescent Sheep
Authors: McGregor Christopher , Salmonsmith Jacob , Burriesci Gaetano , Byrne Guerard
Published: November 2021

Objective

There is growing interest in the application of genetically engineered reduced antigenicity animal tissue for manufacture of bioprosthetic heart valves (BHVs) to reduce antibody induced tissue calcification and accelerated structural valve degeneration (SVD). This study tested biological equivalence of valves made from Gal-knockout (GalKO) and standard porcine pericardium after 90-day mitral valve implantation in sheep.

Methods

GalKO (n = 5) and standard (n = 5) porcine pericardial BHVs were implanted in a randomized and blind fashion into sheep for 90-days. Valve haemodynamic function was measured at 30-day intervals. After explantation, valves were examined for pannus, vegetation, inflammation, thrombus, and tissue calcification.

Results

Nine of 10 recipients completed the study. There was no difference between study groups for haemodynamic performance and no adverse valve-related events. Explanted BHVs showed mild pannus integration and minimal thrombus, with no difference between the groups. Limited focal mineral deposits were detected by x-ray. Atomic spectroscopy analysis detected tissue calcium levels of 1.0 µg/mg ± 0.2 for GalKO BHVs and 1.9 µg/mg ± 0.9 for standard tissue BHVs (p = 0.4), considered to be both low and equivalent.

Conclusions

This is the first demonstration of biological equivalence between GalKO and standard pig pericardium. The GalKO mutation causes neither intrinsic detrimental biological nor functional impact on BHV performance. Commercial adaptation of GalKO tissue for surgical or transcatheter BHVs would remove the clinical disparity between patients producing anti-Gal antibody and BHVs containing the Gal antigen. GalKO BHVs may reduce accelerated tissue calcification and SVD, enhancing patient choices, especially for younger patients.

Graphical Abstract
Coherent Precipitates as a Condition for Ultra-Low Fatigue in Cu-Rich Ti53.7Ni24.7Cu21.6 Shape Memory Alloys
Authors: Bumke L. , Wolff N. , Chluba C. , Dankwort T. , Kienle L. , Quandt E.
Published: November 2021

Sputtered Ti–rich TiNiCu alloys are known to show excellent cyclic stability. Reversibility is mostly influenced by grain size, crystallographic compatibility and precipitates. Isolating their impact on cyclic stability is difficult. Ti2Cu precipitates for instance are believed to enhance reversibility by showing a dual epitaxy with the B2 and B19 lattice. Their influence on the functional fatigue, if they partly lose the coherency is still unknown. In this study, sputtered Ti53.7Ni24.7Cu21.6 films have been annealed at different temperatures leading to a similar compatibility (λ2 ~ 0.99), grain size and thermal cyclic stability. Films annealed at 550 °C exhibit a superior superelastic fatigue resistance but with reduced transformation temperatures and enthalpies. TEM investigations suggest the formation of Guinier–Preston (GP) zone-like plate precipitates and point towards a coherency relation of the B2 phase and finely distributed Ti2Cu precipitates (~ 60 nm). Films annealed at 700 °C result in the growth of Ti2Cu precipitates (~ 280 nm) with an irregular distribution and a partial loss of their coherency. Thus, GP zones are assumed to cause the reduction of transformation temperatures and enthalpies due to increased internal stresses, whereas the coherency relation of both, Ti2Cu and GP zones, help to increase the superelastic stability, well beyond 107 cycles.
Aotearoa New Zealand’s New National History Curriculum and Histories of Mourning
Authors: Bell Avril , Russell Elizabeth
Published: November 2021

From 2022, New Zealand schools are teaching a new compulsory history curriculum that aims to teach diverse New Zealand histories, while foregrounding the centrality of Māori histories and the impacts of colonisation. The new curriculum will upend a long history of ‘forgetting’ the nation’s contentious and conflictual past, and in particular the nineteenth century ‘wars for New Zealand’ (O’Malley, 2016) that secured settler hegemony over the nation-state. In this paper, we focus on the roles of remembering and forgetting in the narration of national histories to explore what might be a productive orientation to take to this contentious and unsettling past. We argue that the new history curriculum inaugurates a new phase of narrating the nation, replacing earlier phases of monocultural and bicultural nationhood that depended on this past being ‘forgotten’. And we argue for the productive value of a histories of critical mourning approach to remembering this founding violence.
Die Abbildung von Wirkungen beruflicher Weiterbildung in der Bildungsberichterstattung: Bestand und Perspektiven
Authors: Echarti Nicolas , Reichart Elisabeth , Gerhards Pia
Published: November 2021

Dieser Beitrag nimmt eine Bestandsaufnahme der indikatorenbasierten Darstellung der Wirkungen beruflicher Weiterbildung in der nationalen Bildungsberichterstattung vor. Dafür werden Wirkungsdimensionen in einer Wirkungskette systematisiert und die Teilbereiche beruflicher Weiterbildung abgegrenzt. Die Analyse relevanter nationaler Berichte zeigt auf, dass die Teilbereiche sehr uneinheitlich abgedeckt sind und überwiegend öffentlich geförderte Weiterbildungsmaßnahmen dargestellt werden. Es dominieren deskriptive Kennziffern zu kurz- und mittelfristigen Bildungserfolgen und -ergebnissen. In den analysierten Berichten liegen hingegen nur wenige analytische Kennziffern und keine Kennziffern zu langfristigen Bildungserträgen vor. Perspektiven der Weiterentwicklung liegen sowohl in einer verbesserten Datennutzung als auch auf konzeptioneller Ebene der Bildungsberichterstattung.
A network-based group testing strategy for colleges
Authors: Zhao Alex , Kumaravel Kavin , Massaro Emanuele , Gonzalez Marta
Published: November 2021

Group testing has recently become a matter of vital importance for efficiently and rapidly identifying the spread of Covid-19. In particular, we focus on college towns due to their density, observability, and significance for school reopenings. We propose a novel group testing strategy which requires only local information about the underlying transmission network. By using cellphone data from over 190,000 agents, we construct a mobility network and run extensive data-driven simulations to evaluate the efficacy of four different testing strategies. Our results demonstrate that our group testing method is more effective than three other baseline strategies for reducing disease spread with fewer tests.
»Ein echter Naturforscher von heute hat eine tiefe Verachtung gegen ›Literatur‹«
Authors: Gronau Magdalena , Gronau Martin
Published: November 2021

Der vorliegende Aufsatz beleuchtet die komplexen Wechselbeziehungen zwischen Physik, Literatur und Philologie in der ersten Hälfte des 20. Jahrhunderts. Ausgehend von einem Brief des österreichischen Physikers Erwin Schrödinger an Ernst Cassirer gehen wir der Frage nach, inwiefern die prominenten deutschsprachigen Vertreter der aufstrebenden theoretischen Physik nicht nur literarische Texte und Inhalte verarbeiteten, sondern in ihrer zutiefst philologisch geprägten Publikations- und Arbeitspraxis auch textwissenschaftlich operierten. Lassen sich in den nachgelassenen und publizierten Schriften von Physikern wie Schrödinger neue Hinweise darauf finden, dass die »Macht der Philologie« noch weit ins Jahrhundert der Physik nachwirken, ja Philologie vielleicht sogar als Wissensmodell in der theoretischen Physik fungieren konnte?
AUV localisation: a review of passive and active techniques
Authors: Maurelli Francesco , Krupiński Szymon , Xiang Xianbo , Petillot Yvan
Published: November 2021

Localisation, i.e. estimation of one’s position in a given environment is a crucial element of many mobile systems, manned and unmanned. Due to the high demand for autonomous exploration, patrolling and inspection services and a rapid improvement of batteries, sensors and machine learning algorithms, the quality of localisation becomes even more important for smart robotic systems. The underwater domain is a very challenging environment due to the water blocking most of the signals over short distances. Recent results in localisation techniques for underwater vehicles are summarised in two principal categories: passive techniques, which strive to provide the best estimation of the vehicle’s position (global or local) given the past and current information from sensors, and active techniques, which additionally produce guidance output that is expected to minimise the uncertainty of estimated position.
Cultivation of hierarchical 3D scaffolds inside a perfusion bioreactor: scaffold design and finite-element analysis of fluid flow
Authors: Sampson Kaylie , Koo Songmi , Gadola Carter , Vasiukhina Anastasiia , Singh Aditya , Spartano Alexandra , Gollapudi Rachana , Duley Matthew , Mueller Jens , James Paul F. , Yousefi Amy M.
Published: November 2021

The use of porous 3D scaffolds for the repair of bone nonunion and osteoporotic bone is currently an area of great interest. Using a combination of thermally-induced phase separation (TIPS) and 3D-plotting (3DP), we have generated hierarchical 3DP/TIPS scaffolds made of poly(lactic-co-glycolic acid) (PLGA) and nanohydroxyapatite (nHA). A full factorial design of experiments was conducted, in which the PLGA and nHA compositions were varied between 6‒12% w/v and 10‒40% w/w, respectively, totaling 16 scaffold formulations with an overall porosity ranging between 87%‒93%. These formulations included an optimal scaffold design identified in our previous study. The internal structures of the scaffolds were examined using scanning electron microscopy and microcomputed tomography. Our optimal scaffold was seeded with MC3T3-E1 murine preosteoblastic cells and subjected to cell culture inside a tissue culture dish and a perfusion bioreactor. The results were compared to those of a commercial CellCeram™scaffold with a composition of 40% β-tricalcium phosphate and 60% hydroxyapatite (β-TCP/HA). Media flow within the macrochannels of 3DP/TIPS scaffolds was modeled in COMSOL software in order to fine tune the wall shear stress. CyQUANT DNA assay was performed to assess cell proliferation. The normalized number of cells for the optimal scaffold was more than twofold that of CellCeram™scaffold after two weeks of culture inside the bioreactor. Despite the substantial variability in the results, the observed improvement in cell proliferation upon culture inside the perfusion bioreactor (vs. static culture) demonstrated the role of macrochannels in making the 3DP/TIPS scaffolds a promising candidate for scaffold-based tissue engineering.
Provable Data Possession (PDP) and Proofs of Retrievability (POR) of Current Big User Data
Authors: Walker Ieuan , Hewage Chaminda , Jayal Ambikesh
Published: November 2021

A growing trend over the last few years is storage outsourcing, where the concept of third-party data warehousing has become more popular. This trend prompts several interesting privacy and security issues. One of the biggest concerns with third-party data storage providers is accountability. This article, critically reviews two schemas/algorithms that allow users to check the integrity and availability of their outsourced data on untrusted data stores (i.e., third-party data storages). The reviewed schemas are provable data possession (PDP) and proofs of retrievability (POR). Both are cryptographic protocols designed to provide clients the assurance that their data are secure on the untrusted data storages. Furthermore, a conceptual framework is proposed to mitigate the weaknesses of the current storage solutions.
Therapeutic Effects of Microsurgical Clipping at Different Time Points on Intracranial Aneurysm and Prognostic Factors
Authors: Huang Ge , Sun Yang , Li Jinhong , Xie Zhengyuan , Tong Xiaoguang
Published: November 2021

Background

Microsurgical clipping is effective for treating early rupture hemorrhage in intracranial aneurysm (IA) patients. We aimed to evaluate the therapeutic effects of microsurgical clipping at different time points on IA and to explore prognostic factors.

Methods

A total of 102 eligible patients were divided into good prognosis group (n = 87) and poor prognosis group (n = 15) according to Glasgow Outcome Scale (GOS) scores at discharge. The effects of microsurgical clipping at different time points (within 24 h, 48 h and 72 h) were compared. The incidence rates of postoperative complications in patients with different Hunt–Hess grades were compared. Prognostic factors were determined by multivariate logistic regression analysis. The nomogram prediction model was established based on independent risk factors and validated.

Results

The good recovery and success rates of complete aneurysm clipping were significantly higher in patients undergoing surgery within 24 h after rupture. The incidence rate of complications was significantly higher in patients with Hunt–Hess grade IV. Good and poor prognosis groups had significantly different age, history of hypertension, preoperative intracranial hematoma volume, aneurysm size, preoperative Hunt–Hess grade, later surgery, postoperative complications and National Institute of Health Stroke Scale (NIHSS) score, as independent risk factors for prognosis. The nomogram model predicted that poor prognosis rate was 14.71%.

Conclusion

Timing (within 24 h after rupture) microsurgical clipping benefits the prognosis of IA patients. Age, history of hypertension, preoperative intracranial hematoma volume, aneurysm size, preoperative Hunt–Hess grade, later surgery, postoperative complications and NIHSS score are independent risk factors for poor prognosis.
MicroRNA-320a-3p Signatures as a Satisfactory Predictor of Acute Coronary Syndrome and Attenuates Inflammation by Targeting X-Linked Inhibitor of Apoptosis Protein
Authors: Zhang Yong , Zhang Zhen , Zhang Aiyuan
Published: November 2021

Acute coronary syndrome (ACS) is a heart disease with a high mortality rate. Recently, more and more evidence illustrated that microRNAs (miRNA) participated in regulating the occurrence of heart disease. This study aimed to detect the level of serum miR-320a-3p in patients with ACS, predict its possibility as a candidate gene for diagnosis, and explore its potential mechanism in the regulation of ACS. 139 ACS patients and 126 controls were recruited in this study. The expression level of miR-320a-3p was determined by qRT-PCR. The predictive value in ACS was assessed by receiver operating characteristic (ROC) curve. Enzyme-linked immunosorbent assay (ELISA) was used to measure the protein expression levels of inflammatory factors. The downstream targets of miR-320a-3p were verified by luciferase reporter gene assay. In ACS patients and rat models, the expression level of serum miR-320a-3p was significantly increased. ROC curve revealed that abnormal expression of miR-320a-3p was of diagnostic value for ACS. In an in vivo rat model, down-regulation of miR-320a-3p inhibited the production of von Willebrand factor (vWF), Heart fatty acid-binding protein (H-FABP), interleukin-1β (IL-1β), IL-6, and tumor necrosis factor-α (TNF-α). In other words, down-regulation of miR-320a-3p reduced rat vascular endothelial injury and inflammation. X-linked inhibitor of apoptosis protein (XIAP) was determined to be a direct target of miR-320a-3p. miR-320a-3p is useful for the diagnosis of ACS. Animal experiments confirmed that up-regulated miR-320a-3p promoted vascular endothelial injury and inflammatory response by targeting XIAP, thus promoting the development of ACS. MiR-320a-3p may be a new breakthrough in the diagnosis and treatment of ACS.
The Market in Poetry in the Persian World
Authors: Bashir Shahzad
Published: November 2021

'Poetic speech is a pearl, connected to the king's ear.' This statement gestures to words as objects of material value sought by those with power and resources. I provide a sense for the texture of the Persian world by discussing what made poetry precious. By focusing on reports on poets' lives, I illuminate the social scene in which poetry was produced and consumed. The discussion elicits poetry's close connections to political and religious authority, economic exchange, and the articulation of gender. At the broadest level, the study substantiates the interdependency between cultural and material reproduction of society.
Considerations for Post-processing Parameters in Mixed-Method 3D Analyses
Authors: Selden Robert Z. , Butaric Lauren N. , Bergstrom Kersten , Van Gerven Dennis
Published: November 2021

The production of three-dimensional (3D) digital meshes of surface and computed tomographic (CT) data has become widespread in morphometric analyses of anthropological and archaeological data. Given that processing methods are not standardized, this leaves questions regarding the comparability of processed and digitally curated 3D datasets. The goal of this study was to identify those processing parameters that result in the most consistent fit between CT-derived meshes and a 3D surface model of the same human mandible. Eight meshes, each using unique thresholding and smoothing parameters, were compared to assess whole-object deviations, deviations along curves, and deviations between specific anatomical features on the surface model when compared with the CT scans using a suite of comparison points. Based on calculated gap distances, the mesh that thresholded at “0” with an applied smoothing technique was found to deviate least from the surface model, although it is not the most biologically accurate. Results have implications for aggregated studies that employ multimodal 3D datasets, and caution is recommended for studies that enlist 3D data from websites and digital repositories, particularly if processing parameters are unknown or derived for studies with different research foci.
The sources of military dissent: Why and how the US military contests civilian decisions about the use of force
Authors: Brooks Risa , Erickson Peter M.
Published: November 2021

How do militaries push back when they oppose civilian initiatives? This article analyses the sources and character of military dissent, focusing on the United States. It details the sources of military preferences over policy and strategy outcomes, emphasising the interplay of role conceptions with other material and ideational factors. It then presents a repertoire of means – tactics of dissent – through which military leaders can exert pressure, constraining and shaping civilians’ decision-making calculus and the implementation of policy and strategy choices. Empirically, it traces military dissent in the 1990s-era humanitarian interventions; the US's ‘War on Drugs’ beginning in the 1980s; and the Afghanistan surge debate in 2009. In so doing, the article contributes to a broader research programme on military dissent across regime types. It also expands scholars’ understandings of preference formation within militaries and illuminates the various pathways through which military dissent operates and potentially undermines civilian control.
Divergent effects of sex and calcium/vitamin D supplementation on serum magnesium and markers of bone structure and function during initial military training
Authors: Hennigar Stephen R. , Kelley Alyssa M. , Nakayama Anna T. , Anderson Bradley J. , McClung James P. , Gaffney-Stomberg Erin
Published: November 2021

Maintaining Mg status may be important for military recruits, a population that experiences high rates of stress fracture during initial military training (IMT). The objectives of this secondary analysis were to (1) compare dietary Mg intake and serum Mg in female and male recruits pre- and post-IMT, (2) determine whether serum Mg was related to parameters of bone health pre-IMT, and (3) whether Ca and vitamin D supplementation (Ca/vitamin D) during IMT modified serum Mg. Females (n 62) and males (n 51) consumed 2000 mg of Ca and 25 μg of vitamin D/d or placebo during IMT (12 weeks). Dietary Mg intakes were estimated using FFQ, serum Mg was assessed and peripheral quantitative computed tomography was performed on the tibia. Dietary Mg intakes for females and males pre-IMT were below the estimated average requirement and did not change with training. Serum Mg increased during IMT in females (0·06 ± 0·08 mmol/l) compared with males (–0·02 ± 0·10 mmol/l; P < 0·001) and in those consuming Ca/vitamin D (0·05 ± 0·09 mmol/l) compared with placebo (0·001 ± 0·11 mmol/l; P = 0·015). In females, serum Mg was associated with total bone mineral content (BMC, β = 0·367, P = 0·004) and robustness (β = 0·393, P = 0·006) at the distal 4 % site, stress–strain index of the polaris axis (β = 0·334, P = 0·009) and robustness (β = 0·420, P = 0·004) at the 14 % diaphyseal site, and BMC (β = 0·309, P = 0·009) and stress–strain index of the polaris axis (β = 0·314, P = 0·006) at the 66 % diaphyseal site pre-IMT. No significant relationships between serum Mg and bone measures were observed in males. Findings suggest that serum Mg may be modulated by Ca/vitamin D intake and may impact tibial bone health during training in female military recruits.
Effect of black soldier fly (Hermetia illucens) larvae meal on lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei
Authors: Chen Yongkang , Chi Shuyan , Zhang Shuang , Dong Xiaohui , Yang Qihui , Liu Hongyu , Tan Beiping , Xie Shiwei
Published: November 2021

The present study investigated the effect of black soldier fly (Hermetia illucens) larvae meal (BSF) on haemolymph biochemical indicators, muscle metabolites as well as the lipid and glucose metabolism of Pacific white shrimp Litopenaeus vannamei. Four diets were formulated in which the control diet contained 25 % of fishmeal (FM) and 10 % (BSF10), 20 % (BSF20), and 30 % (BSF30) of FM protein were replaced with BSF. Four hundred and eighty shrimp (0·88 ± 0·00 g) were distributed to four groups of three replicates and fed for 7 weeks. Results showed that growth performance of shrimp fed BSF30 significantly decreased compared with those fed FM, but there was no significant difference in survival among groups. The whole shrimp crude lipid content, haemolymph TAG and total cholesterol were decreased with the increasing BSF inclusion. The results of metabolomics showed that the metabolite patterns of shrimp fed different diets were altered, with significant changes in metabolites related to lipid metabolism, glucose metabolism as well as TCA cycle. The mRNA expressions of hk, pfk, pk, pepck, ampk, mcd, cpt-1 and scd1 in hepatopancreas were downregulated in shrimp fed BSF30, but mRNA expression of acc1 was upregulated. Unlike BSF30, the mRNA expressions of fas, cpt-1, fbp and 6pgd in hepatopancreas were upregulated in shrimp fed BSF20. This study indicates that BSF20 diet promoted lipid synthesis and lipolysis, while BSF30 diet weakened β-oxidation and glycolysis as well as affected the unsaturated fatty acids synthesis, which may affect the growth performance and body composition of shrimp.
Triassic calc-alkaline lamprophyre dykes from the North Qiangtang, central Tibetan Plateau: evidence for a subduction-modified lithospheric mantle
Authors: Liu Bin , Tang You-Jun , Xing Lü-Ya , Xu Yu , Zhao Shao-Qing , Sun Yang , Huang Jian
Published: November 2021

Primitive lamprophyres in orogenic belts can provide crucial insights into the nature of the subcontinental lithosphere and the relevant deep crust–mantle interactions. This paper reports a suite of relatively primitive lamprophyre dykes from the North Qiangtang, central Tibetan Plateau. Zircon U–Pb ages of the lamprophyre dykes range from 214 Ma to 218 Ma, with a weighted mean age of 216 ± 1 Ma. Most of the lamprophyre samples are similar in geochemical compositions to typical primitive magmas (e.g. high MgO contents, Mg no. values and Cr, with low FeOt/MgO ratios), although they might have experienced a slightly low degree of olivine crystallization, and they show arc-like trace-element patterns and enriched Sr–Nd isotopic composition ((87Sr/86Sr)i = 0.70538–0.70540, ϵNd(t) = −2.96 to −1.65). Those geochemical and isotopic variations indicate that the lamprophyre dykes originated from partial melting of a phlogopite- and spinel-bearing peridotite mantle modified by subduction-related aqueous fluids. Combining with the other regional studies, we propose that slab subduction might have occurred during Late Triassic time, and the rollback of the oceanic lithosphere induced the lamprophyre magmatism in the central Tibetan Plateau.
Association between women’s empowerment and diarrhoea in children under five years: evidence from the 2017/18 Benin Demographic and Health Survey
Authors: Zegeye Betregiorgis , Idriss-Wheeler Dina , Yaya Sanni
Published: November 2021

Globally, diarrhoea is the third leading cause of death for under five-children. Women’s empowerment can significantly reduce under-five mortality due to diarrhoea. This study investigated the association between women’s empowerment and childhood diarrhoea in Benin using data from the 2017/18 Benin Demographic and Health Survey. A total of 7979 currently married women were included in the study. A logistic regression model was used to control for possible confounders. The prevalence of diarrhoea among children under five years of age was 13.6%. About 36.3% of the currently married women decided either alone or together with their husband on their own health, purchase of large household items and visiting family/relatives. Close to 65.4% of currently married women disagreed with all five reasons to justify wife-beating. The children of mothers who had decision-making power were less likely to have diarrhoea (aOR = 0.74, 95% CI: 0.57–0.96) than the children of mothers who had no decision-making power. Moreover, the children of mothers who disagreed with all five reasons to justify wife-beating (aOR = 0.79, 95% CI: 0.65–0.96) were less likely to have diarrhoea than the children of mothers who accepted wife-beating as a part of life. Women’s age, educational level, wealth index and region were associated with childhood diarrhoea in Benin. The role of women’s empowerment, as determined by decision-making power and wife-beating attitude, was found to be significantly associated with the risk of childhood diarrhoea in Benin, after adjusting for other variables. Therefore, it is essential for policymakers in Benin to reinforce strategies and interventions focusing on women’s empowerment to avert childhood mortality caused by diarrhoea. This includes improving household economic status, women’s education and decision-making power and enhancing awareness of women’s human and democratic rights.
Local anaesthetic techniques in endoscopic sinonasal surgery: a contemporaneous review
Authors: Watts E , Thompson A , Pankhania M , Okonkwo O , Ahmed S
Published: November 2021

Objective

Endoscopic endonasal surgery is a minimally invasive technique that has revolutionised the management of complex neurosurgical, otolaryngological, skull-base and craniofacial lesions. Traditionally performed under general anaesthetic, this study explores the growing role of local anaesthetic techniques.

Method

A contemporaneous review of modified dental techniques and intraoral anatomy provides a supportive guide for performing endoscopic sinus surgery under local anaesthetic.

Results

The practical procedures for four midfacial nerve blocks are described with relevance to endoscopic surgery under local anaesthetic. Anatomy, surgical technique and potential complications are discussed for the incisive foramen block, sphenopalatine ganglion block (via endonasal approach), maxillary nerve block (via the greater palatine foramen and the transoral lateral pterygoid plate approach) and transcutaneous approach to the pterygomaxillary fissure.

Conclusion

Ultimately, such techniques may extend the safety and efficacy of endoscopic sinus surgery, limit surgical risk and increase satisfaction for patients, surgeons and healthcare managers alike.
Evaluating the impact of the first 10 years of the Cambridge Masters in Conservation Leadership
Authors: Sandbrook Chris , Nelson Howard P. , Bolderson Shelley , Leader-Williams Nigel
Published: November 2021

Conservation lacks sufficient well-trained leaders who are empowered to catalyse positive change for the natural world. Addressing this need, the University of Cambridge launched a Masters in Conservation Leadership in 2010. The degree includes several features designed to enhance its impact. Firstly, it recruits international, gender-balanced cohorts of mid-career professionals, building leadership capacity in the Global South and providing a rich environment for peer learning. Secondly, teaching includes applied leadership training in topics such as fundraising, leading people and networking, as well as interdisciplinary academic topics. Thirdly, the degree is delivered through the Cambridge Conservation Initiative, a partnership of international NGOs and networks, facilitating extensive practitioner-led and experiential learning. We present details of programme design and evaluate the impact of the Masters after 10 years, using data from course records, student and alumni perspectives, and interviews with key stakeholders. The course has broadly succeeded in its design and recruitment objectives. Self-assessed leadership capabilities, career responsibilities and the overall impact of alumni increased significantly 5 years after graduation. However, specific impacts of alumni in certain areas, such as on their professional colleagues, have been less clear. We conclude by outlining future plans for the Masters in light of growing demands on conservation leaders and the changing landscape of leadership capacity development. These include reforms to course structure and assessment, long-term support to the alumni network and developing a conservation leadership community of practice.
Congenital transmission of Mexican strains of Trypanosoma cruzi TcIa: interaction between parasite and human placental explants
Authors: Barbosa Cecilia Gomes , Gómez-Hernández César , da Silva Marcos Vinícius , Rezende-Oliveira Karine , Ferreira Paula Tatiana Mutão , de Oliveira Ana Carolina Morais , Desidério Chamberttan Souza , Helmo Fernanda Rodrigues , de Carvalho-Costa Tamires Marielem , Dos Santos Ingrid Ketlen Pereira , Saraiva Lorena Kelly Alves , de Oliveira Carlo José Freire , Machado Juliana Reis , Ferro Eloisa Amália Vieira , Rodrigues Virmondes , Ramirez Luís Eduardo
Published: November 2021

Congenital transmission of Chagas disease plays an important role in endemic countries because it is not a diagnosis that is encountered frequently in prenatal care. Due to limited information regarding congenital transmission of Trypanosoma cruzi in Mexico, the present study aimed to investigate protozoan infectivity and modulation of immune responses in human placental explants infected with T. cruzi Ia Mexican strains. The Inc-5 strain showed increased infectivity and modulated IL-1β, IL-10 and TLR-4, decreasing their expression after 24 h of infection. Both strains (Inc-5 and Ninoa) stimulated the production of TNF-α and decreased IL-6 levels 96 h after infection. An important detachment of the syncytiotrophoblast caused by infection with T. cruzi was observed after 24 h of infection. In this study, ex vivo infection of human placental villi was performed to better understand interactions involving parasitic T. cruzi and human placental tissue. It was concluded that the strains of TcIa present parasitism in placental tissue, modulation of the innate immune system of the placenta, and cause intense detachment of the syncytiotrophoblast, a fact that may be more associated with abortion and premature birth events than the congenital transmission itself, justifying the low rate of this transmission mechanism by this genotype.
Endocrinopathies mimicking gene negative long QT syndrome
Authors: Chakraborty Praloy , Roberts Jason D. , Gollob Michael H.
Published: November 2021

Ventricular repolarisation can be influenced by hormonal milieu which may mimic long QT syndrome. We describe a series of patients referred for genetic testing for diagnosed long QT syndrome where a detailed clinical workup demonstrated endocrinopathies as the cause of presumed “gene negative” long QT syndrome and QT prolongation.
Determinants of vegetable intake among urban socio-economically disadvantaged adolescents: a systematic review of quantitative studies
Authors: Bel-Serrat Silvia , von der Schulenburg Antje , Mullee Amy , Murrin Celine
Published: November 2021

Objective:

To investigate the determinants of vegetable intake in urban socio-economically disadvantaged adolescents to inform the development of an intervention programme.

Design:

A narrative systematic review was carried out by searching five electronic databases from 2013 to 2020. The descriptors used for the search strategy were vegetable intake, adolescents, determinants and correlates. Inclusion criteria were including a sample of socio-economically disadvantaged adolescents aged 12–18 years, evaluation of the association between vegetable intake and determinants of intake, and conducted in urban settings of high-income countries. Thirteen studies met the inclusion criteria. Identified determinants of vegetable intake were reported according to the five levels of the socio-ecological model of health.

Setting:

Studies included in the review were conducted in four countries: USA (n 8), Australia (n 3), Ireland (n 1) and New Zealand (n 1).

Participants:

Adolescents aged 12–18 years from socio-economically disadvantaged backgrounds living in urban settings.

Results:

Thirty-nine determinants were identified. Nutrition knowledge was the only determinant consistently investigated in several independent samples which was not associated with vegetable intake in socio-economically disadvantaged adolescents. For the remaining potential determinants, it was not possible to examine the consistency of evidence as there were not enough studies investigating the same determinants. Most of the studies followed a cross-sectional design and were carried out in school settings.

Conclusions:

There is a need for further studies on the determinants of vegetable intake in this population preferably with longitudinal designs and beyond the school setting in different countries to guide the development of successful interventions.
Confocal Microscopy in Ecophysiological Studies of Algae: A Door to Understanding Autofluorescence in Red Algae
Authors: Coronado-Parra Teresa , Roldán Mónica , Aboal Marina
Published: November 2021

Alga in the genus Chroothece have been reported mostly from aquatic or subaerial continental environments, where they grow in extreme conditions. The strain Chroothece mobilis MAESE 20.29 was exposed to different light intensities, red and green monochromatic light, ultraviolet (UV) radiation, high nitrogen concentrations, and high salinity to assess the effect of those environmental parameters on its growth. Confocal laser scanning microscopy (CLSM) was used as an “in vivo” noninvasive single-cell method for the study. The strain seemed to prefer fairly high light intensities and showed a significant increase in allophycocyanin (APC) and chlorophyll a [photosystem I (PSI) and photosystem II (PSII)] fluorescence with 330 and 789 μM/cm2/s intensities. Green monochromatic light promoted a significant increase in the fluorescence of APC and chlorophyll a (PSI and PSII). UV-A significantly decreased phycocyanin and increased APC, while UV-A + B showed a greater decreasing effect on c-Phycocyanin but did not significantly change concentrations of APC. The increase in nitrogen concentration in the culture medium significantly and negatively affected all pigments, and no effect was observed with an increase in salinity. Our data show that CLSM represents a very powerful tool for ecological research of microalgae in small volumes and may contribute to the knowledge of phycobiliproteins in vivo behavior and the parameters for the large-scale production of these pigments.
How counterterrorism throws back wartime medical assistance and care to pre-Solferino times
Authors: Bouchet-Saulnier Françoise
Published: November 2021

Domestic counterterrorism (CT) frameworks have been increasingly employed to criminalize impartial medical care to wounded and sick from non-State armed groups labelled as criminal or terrorist in non-international armed conflicts (NIACs). It has also contributed to legitimize attacks and incidental damage on medical facilities in armed conflicts overlooking the international humanitarian law (IHL) protection afforded to the wounded and sick as well as to medical personnel and facilities. This article compares the treatment of the wounded and sick in both international armed conflicts (IACs) and NIACs in the context of the global war on terrorism. It demonstrates the impacts that CT measures have on the IHL protection of the medical mission while demonstrating the increased acceptance that some incidental damages, such as the downgrading of IHL core protections, are tolerated, by some countries in the global fight against terrorism. The article further illustrates how the special criminal status of wounded and sick from non-State armed groups in armed conflicts that are evolving in a CT context can mechanically contaminate the status of impartial humanitarian medical activities, facilities and personnel in such contexts. It also shows how the simultaneous application of CT and IHL in numerous contexts of armed conflict as well as the involvement of State armed forces under those two different bodies of law contributes to blurring the lines between IHL and CT, between protected or “criminal” humanitarian and medical activities. In contexts of complex military operations, this reality creates a mind-set conducive to legal mistakes and security incidents on the medical mission. Although there is a distinction between the protection from attacks and the protection from prosecution under IHL, in practice, numerous military operations to arrest are launched in ways similar to attacks and can end up with some killings. The article concludes that States could easily limit the impact of CT on IHL by adding an exemption in their CT framework for humanitarian and medical assistance that is compatible with IHL. This is the first necessary condition – even if obviously not a sufficient one – to end the legal ambiguity between IHL and State domestic law as to the criminalization or loss of the IHL protected status for the much necessary needed medical assistance and care activities in times of armed conflict that are evolving in a CT context.
Digitale Palliative Care
Authors: Amann Manuel , Blum David
Published: November 2021

Zusammenfassung. Palliative Care wird immer digitaler. Der Artikel beleuchtet, wie digitale Ansätze helfen können bei der Identifikation von Patientinnen und Patienten, die für Angebote der Palliative Care qualifizieren und diese in Anspruch nehmen möchten. Digitale Ansätze können zum Monitoring von Patientinnen und Patienten durch Apps und Wearables eingesetzt werden, aber auch in der psychosozialen und spirituellen Begleitung werden digitale Methoden wichtiger. An einem Fall wird der therapeutische Einsatz von virtueller Realität dargelegt. Die Arbeitsorganisation – und seit der Coronakrise auch die Lehre – ist digital geworden. Bei allen Vorteilen müssen aber auch die möglichen Nachteile betrachtet werden, welche die Digitalisierung mit sich bringt.
Der patientenzentrierte Notfallplan – Erfahrungen aus der Praxis
Authors: Loupatatzis Barbara , Karzig-Roduner Isabelle
Published: November 2021

Zusammenfassung. Der Wunsch vieler Menschen in der Schweiz ist es, zu Hause sterben zu können. Der vorliegende Praxisbericht zeigt beispielhaft, wie die Zusammenarbeit von Hausärztinnen und Hausärzten und einem spezialisierten Palliative- Care-Team sowie die Anwendung eines individuell auf das Therapieziel und die Grundkrankheit der Patientin/des Patienten adaptierten Notfallplans die Umsetzung dieses Wunsches unterstützen können. Eine gute Koordination der gesundheitlichen Vorausplanung (Advance Care Planning) durch einen individualisierten, patientenzentrierten Notfallplan sowie die gemeinsame Umsetzung der Betreuung durch das interdisziplinäre, multiprofessionelle Behandlungsteam und die Organisation eines gutes Betreuungsnetzwerks sind essenzielle Bestandteile, damit ungewollte Notfallhospitalisationen am Lebensende vermieden werden können.
FPGA Design for On‐Board Measurement of Intermittency From In‐Situ Satellite Data
Authors: Deak N. , Creț O. , Munteanu C. , Teodorescu E. , Echim M. M.
Published: November 2021

Intermittency is a fundamental property of space plasma dynamics, characterizing turbulent dynamical variables as well as passive scalars. Its qualitative and quantitative description from in‐situ data requires an accurate estimation of the probability density functions (PDFs) of fluctuations and their moments, particularly the flatness, a normalized fourth order moment of the PDF. Such a statistical description needs a sufficiently large number of samples for the computation to be meaningful. Due to inherent technological limitations (e.g., limited telemetry bandwidth) not all samples collected on‐board can be sent to the ground for further analysis. Therefore, a technology designed to process on‐board the data and to compute the flatness is useful to fully exploit the capabilities of scientific instruments installed on robotic platforms, including nanosatellites. We designed, built, and tested in laboratory such a technology based on Field Programable Gate Arrays (FPGA). The building principle is the classical estimation of PDFs and their moments, based on normalized histograms of a measure. The technical design uses the FloPoCo (Floating‐Point Cores) framework with customized arithmetic operators; the computation block is a pipelined architecture, which computes a new value of the flatness in each clock cycle. The design and implementation achieve optimization directives of the FPGA resources relevant for operation in space, like area, energy efficiency, and precision. The technology was tested in laboratory using Xilinx SRL16 or SRLC32 macros and provides correct results validated with test time series provided by magnetic field data collected in the solar wind by ULYSSES spacecraft. The characteristics and performance of the laboratory prototype pave the way for a space qualified version of the laboratory design.