bluuebunny/crossref_metadata_2025 huggingface dataset:
TRADE LIBERALIZATION AND CONSUMER VULNERABILITY: A LEGAL FRAMEWORK ON LEGISLATIONS AND TESTING MECHANISM FOR ASEAN PRODUCT SAFETY DIRECTIVE
Authors: Alsagoff Syed Sagoff , Ismail Rahmah
Published: October 2017

Since its inception in 1967 ASEAN has advanced in great leaps in the economic sector luring new member states into its pact. From a mere five member states (Malaysia, Indonesia, Thailand, Singapore and the Philippines) ASEAN has today managed to entice five other neighbouring states (Brunei 1984, Vietnam 1995, Laos & Myanmar 1997, Cambodia 1999) into its pact transforming itself into union of ten member states with a consumer population expected to exceed 600 million people. In order to ensure sustainability amid global challenges, member states have engrossed ASEAN Charter in 2007 with a view of creating an ASEAN Economic Community by 2015 that is robust, competitive and sustainable. At this juncture, ASEAN has to realize that like any trade liberalization initiatives, goods moved readily and freely throughout the free-trade area that is facilitated by a lucrative non-barrier tariffs incentives. This vision of a single market which creates a frontier without borders can prove to be advantageous to member states only if they have the required vehicle that is able to overcome the drawback of its progression through harmonization and synchronization efforts that is effective and successful. Like everything else, every advantage has some disadvantages attached to it. This article will address important determining factors that are crucial in the development and scope of proposed ASEAN Product Safety Directive including reviewing relevant determining factors such as regional stability, consumer protection legislations and standard and testing agencies of which one without the other will be incomplete. The proposals suggested in this article will strengthen and unite ASEAN in overcoming unsafe product issues at ASEAN level.
Legal Status of Credit Bank Guarantee in Indonesia’s Legal Guarantee
Authors: Putriyanti Erma Defiana
Published: October 2017

The aim of this research is to analyze  about the legal status of the letter hiring as collateral for bank loans in the Indonesian security law. The method of this research is a normative juridical. The results of this research indicate that the decree hiring is not included in the objects that can be bound by pledge, fiduciary, and mortgage then hiring decree hiring is not included in the personal guarantee and corporate guarantee. Although the hiring decree is issued by a legitimate institution, the institution is not bound by an agreement between the debtor debts with the bank but when the decree was used as security for the bank. Hiring letter is not also included in the general collateral. Decree hiring is not an object and does not qualify as material that can be used as general collateral. The conclusion of this research is that the position of the decree hiring as collateral for bank loans is a new form of guarantee which is not included in the general guarantees and the specific ones. This shows that the system of legal guarantees in Indonesia is not pure anymore embrace a closed system, but has started shifting into an open system.
Qualitative Analysis of Ride-Hailing Regulations in Major American Cities
Authors: Beer Rachel , Brakewood Candace , Rahman Subrina , Viscardi Jennifer
Published: October 2017

Ride-hailing services, which are provided by companies such as Uber and Lyft, are increasingly common in many American cities. Several cities are now regulating or considering regulation of these services. However, regulation has not been well documented across jurisdictions, and city planners and policy makers often want to understand what regulations are being put in place in comparable metropolitan areas. Therefore, the objective of this research was to provide a qualitative comparison of the regulations of ride-hailing companies between major American cities. This goal was accomplished through the evaluation of five driver-related and three company-related types of ride-hailing regulations in 15 major American cities. The driver-related regulations included requirements for background checks, driver’s licenses, vehicle registrations, special licenses such as business licenses, and external vehicle displays. The company-related regulations included requirements for the number of ride-hailing vehicles operating in a metropolitan area, providing a list of drivers to the city, and sharing trip data with the city. The results of this qualitative analysis reveal significant variation in the number of driver-related regulations imposed in the cities that were evaluated. Another key finding is that ride-hailing companies may be less likely to operate in cities where fingerprint-based background checks are mandatory. As ride-hailing regulations continue to evolve, this research can help planners and policy makers better understand the current state of local regulations by providing a systematic comparison across major metropolitan areas in the United States.
Two-Stage Stochastic Programming Model for Robust Personal Rapid Transit Network Design
Authors: Zhao Kangjia , Jin Jian Gang , Lee Der-Horng
Published: October 2017

This study investigated the personal rapid transit (PRT) guideway network design problem at a strategic level. PRT is known as an on-demand mobility method serving the first or last mile of travel demand, which can fluctuate significantly during a day. This on-demand property may make the system vulnerable to changes in the pattern of demand. The robustness of the PRT guideway network refers to the capability to fit different demand patterns. The motivation of this study was to take the uncertainty of demand into consideration in the process of network design to enhance the robustness of the PRT guideway network in operation. This problem was formulated as a two-stage stochastic linear programming model. The model was applied to a case study with real travel demand data from Singapore. The results of the comparison study show that the network designed via the proposed model is robust and cost-effective.
Intubation biomechanics: validation of a finite element model of cervical spine motion during endotracheal intubation in intact and injured conditions
Authors: Gadomski Benjamin C. , Shetye Snehal S. , Hindman Bradley J. , Dexter Franklin , Santoni Brandon G. , Todd Michael M. , Traynelis Vincent C. , From Robert P. , Fontes Ricardo B. , Puttlitz Christian M.
Published: October 2017

OBJECTIVE

Because of limitations inherent to cadaver models of endotracheal intubation, the authors’ group developed a finite element (FE) model of the human cervical spine and spinal cord. Their aims were to 1) compare FE model predictions of intervertebral motion during intubation with intervertebral motion measured in patients with intact cervical spines and in cadavers with spine injuries at C-2 and C3–4 and 2) estimate spinal cord strains during intubation under these conditions.

METHODS

The FE model was designed to replicate the properties of an intact (stable) spine in patients, C-2 injury (Type II odontoid fracture), and a severe C3–4 distractive-flexion injury from prior cadaver studies. The authors recorded the laryngoscope force values from 2 different laryngoscopes (Macintosh, high intubation force; Airtraq, low intubation force) used during the patient and cadaver intubation studies. FE-modeled motion was compared with experimentally measured motion, and corresponding cord strain values were calculated.

RESULTS

FE model predictions of intact intervertebral motions were comparable to motions measured in patients and in cadavers at occiput–C2. In intact subaxial segments, the FE model more closely predicted patient intervertebral motions than did cadavers. With C-2 injury, FE-predicted motions did not differ from cadaver measurements. With C3–4 injury, however, the FE model predicted greater motions than were measured in cadavers. FE model cord strains during intubation were greater for the Macintosh laryngoscope than the Airtraq laryngoscope but were comparable among the 3 conditions (intact, C-2 injury, and C3–4 injury).

CONCLUSIONS

The FE model is comparable to patients and cadaver models in estimating occiput–C2 motion during intubation in both intact and injured conditions. The FE model may be superior to cadavers in predicting motions of subaxial segments in intact and injured conditions.
Ethnopharmacological basis for antispasmodic, antidiarrheal and antiemetic activities of Ceratonia siliqua pods
Authors: Hamid Irfan , Janbaz Khalid Hussain
Published: October 2017

The study was conducted to provide the ethnopharmacological bases of the crude extract of seed pods of Ceratonia siliqua in the gastrointestinal spasm, diarrhea and emesis. In segregated rabbit jejunum, it showed dose-dependent (0.01-10 mg/mL) relaxation of spontaneous as well as carbachol (1 µM)-induced contraction. Pre-treatment of segregated rat ileum with C. siliqua, significantly (p<0.0001) suppressed the carbachol (1 µM)-induced contraction similar to atropine (1 µM). These results indicated that C. siliqua possesses spasmolytic activity through possible blockage of muscarinic receptor in jejunum preparations. Furthermore, the crude extract inhibited the castor oil-induced diarrhea, charcoal meal propulsion in mice and copper sulfate-induced retches in chicks in a dose-dependent manner (100, 200, 300 mg/kg). These in vitro and in vivo results indicate that C. siliqua possesses the spasmolytic and antidiarrheal activities mediated possibly through blockage of muscarinic receptors. Thus, this study provides a rationale for its folkloric use.

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Observed and Projected Precipitation Changes over the Nine US Climate Regions
Authors: Chylek Petr , Dubey Manvendra , Hengartner Nicholas , Klett James
Published: October 2017

We analyze the past (1900–2015) temperature and precipitation changes in nine separate US climate regions. We find that the temperature increased in a statistically significant (95% confidence level equivalent to alpha level of 0.05) manner in all of these regions. However, the variability in the observed precipitation was much more complex. In the eastern US (east of Rocky Mountains), the precipitation increased in all five climate regions and the increase was statistically significant in three of them. In contract, in the western US, the precipitation increased in two regions and decreased in two with no statistical significance in any region. The CMIP5 climate models (an ensemble mean) were not able to capture properly either the large precipitation differences between the eastern and the western US, or the changes of precipitation between 1900 and 2015 in eastern US. The statistical regression model explains the differences between the eastern and western US precipitation as results of different significant predictors. The anthropogenic greenhouse gases and aerosol (GHGA) are the major forcing of the precipitation in the eastern part of US, while the Pacific Decadal Oscillation (PDO) has the major influence on precipitation in the western part of the US. Our analysis suggests that the precipitation over the eastern US increased at an approximate rate of 6.7%/K, in agreement with the Clausius-Clapeyron equation, while the precipitation of the western US was approximately constant, independent of the temperature. Future precipitation over the western part of the US will depend on the behavior of the PDO, and how it (PDO) may be affected by future warming. Low hydrological sensitivity (percent increase of precipitation per one K of warming) projected by the CMIP5 models for the eastern US suggests either an underestimate of future precipitation or an overestimate of future warming.
Financing Cocaine Use in a Homeless Population
Authors: North Carol , Pollio David
Published: October 2017

Background: Cocaine use is highly prevalent among homeless populations, yet little is known about how it is financed. This study examined associations of income sources with cocaine use and financing of drugs in a longitudinal evaluation of a homeless sample. Methods: A homeless sample was recruited systematically in St. Louis in 1999–2001 and longitudinally assessed annually over two years using the Diagnostic Interview Schedule and the Homeless Supplement, with urine drug testing. Results: More than half (55%) of participants with complete follow-up data (N = 255/400) had current year cocaine use. Current users spent nearly $400 (half their income) in the last month on drugs at baseline. Benefits, welfare, and disability were negatively associated and employment and income from family/friends, panhandling, and other illegal activities were positively associated with cocaine use and monetary expenditures for cocaine. Conclusions: Findings suggest that illegal and informal income-generating activities are primary sources for immediate gratification with cocaine use and public entitlements do not appear to be primary funding sources used by homeless populations. Policy linking drug testing to benefits is likely to have little utility, and public expenditures on measures to unlink drug use and income might be more effectively used to fund employment and treatment programs.
Performance of an Active Micro Direct Methanol Fuel Cell Using Reduced Catalyst Loading MEAs
Authors: Falcão D.S. , Silva R.A. , Rangel C.M. , Pinto A.M.F.R.
Published: October 2017

The micro direct methanol fuel cell (MicroDMFC) is an emergent technology due to its special interest for portable applications. This work presents the results of a set of experiments conducted at room temperature using an active metallic MicroDMFC with an active area of 2.25 cm2. The MicroDMFC uses available commercial materials with low platinum content in order to reduce the overall fuel cell cost. The main goal of this work is to provide useful information to easily design an active MicroDMFC with a good performance recurring to cheaper commercial Membrane Electrode Assemblies MEAs. A performance/cost analysis for each MEA tested is provided. The maximum power output obtained was 18.1 mW/cm2 for a hot-pressed MEA with materials purchased from Quintech with very low catalyst loading (3 mg/cm2 Pt–Ru at anode side and 0.5 mg/cm2 PtB at the cathode side) costing around 15 euros. Similar power values are reported in literature for the same type of micro fuel cells working at higher operating temperatures and substantially higher cathode catalyst loadings. Experimental studies using metallic active micro direct methanol fuel cells operating at room temperature are very scarce. The results presented in this work are, therefore, very useful for the scientific community.
A Market-Based Analysis on the Main Characteristics of Gearboxes Used in Onshore Wind Turbines
Authors: Vázquez-Hernández Cristina , Serrano-González Javier , Centeno Gabriel
Published: October 2017

Even though wind energy is one of the most mature renewable technologies, it is in continuous development not only because of the trend towards larger wind turbines but also because of the development of new technological solutions. The gearbox is one of the components of the drive train in which the industry is concentrating more effort on research and development. Larger rotor blades lead to more demanding requirements for this component as a consequence of a higher mechanical torque and multiplication ratio (due to lower rotational speed of blades while the rotational speed on the generator side remains at similar values). In addition, operating conditions become increasingly demanding in terms of reliability, performance, and compactness. This paper analyses the different gearbox arrangements that are implemented by manufacturers of onshore wind turbines, as well as their market penetration (including different aspects that affect the design of the gearbox, such as drive train configuration and turbine size). The analysis carried out shows a clear convergence towards gearboxes with three stages. However, there is a noticeable diversity in the types of gears used, depending to a large extent on the preferences of each manufacturer but also on the nominal power of the wind turbine and drive train configuration.
A Novel Multi-Phase Stochastic Model for Lithium-Ion Batteries’ Degradation with Regeneration Phenomena
Authors: Zhang Jianxun , He Xiao , Si Xiaosheng , Hu Changhua , Zhou Donghua
Published: October 2017

A lithium-Ion battery is a typical degradation product, and its performance will deteriorate over time. In its degradation process, regeneration phenomena have been frequently encountered, which affect both the degradation state and rate. In this paper, we focus on how to build the degradation model and estimate the lifetime. Toward this end, we first propose a multi-phase stochastic degradation model with random jumps based on the Wiener process, where the multi-phase model and random jumps at the changing point are used to describe the variation of degradation rate and state caused by regeneration phenomena accordingly. Owing to the complex structure and random variables, the traditional Maximum Likelihood Estimation (MLE) is not suitable for the proposed model. In this case, we treat these random variables as latent parameters, and then develop an approach for model identification based on expectation conditional maximum (ECM) algorithm. Moreover, depending on the proposed model, how to estimate the lifetime with fixed changing point is presented via the time-space transformation technique, and the approximate analytical solution is derived. Finally, a numerical simulation and a practical case are provided for illustration.
The Effects of Plant Growth Regulators on Cell Growth, Protein, Carotenoid, PUFAs and Lipid Production of Chlorella pyrenoidosa ZF Strain
Authors: Du Huanmin , Ahmed Faruq , Lin Bin , Li Zhe , Huang Yuhan , Sun Guang , Ding Huan , Wang Chang , Meng Chunxiao , Gao Zhengquan
Published: October 2017

In the present study, eight kinds plant growth regulators—salicylic acid (SA), 1-naphthaleneacetic acid (NAA), gibberellic acid (GA3), 6-benzylaminopurine (6-BA), 2, 4-epi-brassinolide (EBR), abscisic acid (ABA), ethephon (ETH), and spermidine (SPD)—were used to investigate the impact on microalgal biomass, lipid, total soluble protein, carotenoids, and polyunsaturated fatty acids (PUFAS) production of Chlorella pyrenoidosa ZF strain. The results showed the quickest biomass enhancement was induced by 50 mg·L−1 NAA, with a 6.3-fold increase over the control; the highest protein content was increased by 0.005 mg·L−1 ETH, which produced 3.5-fold over the control; total carotenoids content was induced most effectively by 1 mg·L−1 NAA with 3.6-fold higher production than the control; the most efficient elicitor for lipid production was 5 mg·L−1 GA3 at 1.9-fold of the control; 0.2 mg·L−1 ETH induced the abundant production of 1.82 ± 0.23% linoleic acid; 0.65 ± 0.01% linolenic acid was induced by 1 mg·L−1 NAA; 2.53 ± 0.15% arachidonic acid and 0.44 ± 0.05% docosahexaenoic acid were induced by 5 mg·L−1 GA3. Transcriptional expression levels of seven lipid-related genes, including ACP, BC, FAD, FATA, KAS, MCTK, and SAD, were studied by real-time RT-q-PCR. 5 mg·L−1 GA3 was the most effective regulator for transcriptional expressions of these seven genes, producing 23-fold ACP, 31-fold BC, 25-fold FAD, 6-fold KAS, 12-fold MCTK compared with the controls, respectively.
Non-Newtonian Flow Characteristics of Heavy Oil in the Bohai Bay Oilfield: Experimental and Simulation Studies
Authors: Xin Xiankang , Li Yiqiang , Yu Gaoming , Wang Weiying , Zhang Zhongzhi , Zhang Maolin , Ke Wenli , Kong Debin , Wu Keliu , Chen Zhangxin
Published: October 2017

In this paper, physical experiments and numerical simulations were applied to systematically investigate the non-Newtonian flow characteristics of heavy oil in porous media. Rheological experiments were carried out to determine the rheology of heavy oil. Threshold pressure gradient (TPG) measurement experiments performed by a new micro-flow method and flow experiments were conducted to study the effect of viscosity, permeability and mobility on the flow characteristics of heavy oil. An in-house developed novel simulator considering the non-Newtonian flow was designed based on the experimental investigations. The results from the physical experiments indicated that heavy oil was a Bingham fluid with non-Newtonian flow characteristics, and its viscosity-temperature relationship conformed to the Arrhenius equation. Its viscosity decreased with an increase in temperature and a decrease in asphaltene content. The TPG measurement experiments was impacted by the flow rate, and its critical flow rate was 0.003 mL/min. The TPG decreased as the viscosity decreased or the permeability increased and had a power-law relationship with mobility. In addition, the critical viscosity had a range of 42–54 mPa∙s, above which the TPG existed for a given permeability. The validation of the designed simulator was positive and acceptable when compared to the simulation results run in ECLIPSE V2013.1 and Computer Modelling Group (CMG) V2012 software as well as when compared to the results obtained during physical experiments. The difference between 0.0005 and 0.0750 MPa/m in the TPG showed a decrease of 11.55% in the oil recovery based on the simulation results, which demonstrated the largely adverse impact the TPG had on heavy oil production.
Optimal Design of Permanent Magnet Arrangement in Synchronous Motors
Authors: Liu Xiaoyu , Lin Qifang , Fu Weinong
Published: October 2017

A general pattern, which can include different types of permanent magnet (PM) arrangement in PM synchronous motors (PMSMs) is presented. By varying the geometric parameters of the general pattern, the template can automatically produce different types of PM arrangement in the rotor. By choosing the best arrangement of PMs using optimization method, one can obtain a better performance and lower manufacturing cost. Six of the most widely used conventional types of rotor structures can be obtained through the parameter variation of the general pattern. These types include five embedded PM types and a traditional surface-mounted PM type. The proposed approach combines optimization method embedded with finite element method (FEM) for solving the multi-objective optimization for the PM structures. To save computing load, this paper employs a strategy of sub-group optimization, which is on account of the impact levels of the design parameters on the objective functions, and a parallel computation, which is a valid method to shorten the computing time. As an application example, a PMSM is optimally designed. Its simulation results and prototype experiments are provided to showcase the effectiveness of the proposed method.
A Two-Dimensional Multiphysics Coupling Model of a Middle and Low Temperature Solar Receiver/Reactor for Methanol Decomposition
Authors: Wang Yanjuan , Liu Qibin , Lei Jing , Li Jiwei , Chen Can
Published: October 2017

Abstract: In this paper, the endothermic methanol decomposition reaction is used to obtain syngas by transforming middle and low temperature solar energy into chemical energy. A two-dimensional multiphysics coupling model of a middle and low temperature of 150~300 °C solar receiver/reactor was developed, which couples momentum equation in porous catalyst bed, the governing mass conservation with chemical reaction, and energy conservation incorporating conduction/convection/radiation heat transfer. The complex thermochemical conversion process of the middle and low temperature solar receiver/reactor (MLTSRR) system was analyzed. The numerical finite element method (FEM) model was validated by comparing it with the experimental data and a good agreement was obtained, revealing that the numerical FEM model is reliable. The characteristics of chemical reaction, coupled heat transfer, the components of reaction products, and the temperature fields in the receiver/reactor were also revealed and discussed. The effects of the annulus vacuum space and the glass tube on the performance of the solar receiver/reactor were further studied. It was revealed that when the direct normal irradiation increases from 200 W/m2 to 800 W/m2, the theoretical efficiency of solar energy transformed into chemical energy can reach 0.14–0.75. When the methanol feeding rate is 13 kg/h, the solar flux increases from 500 W/m2 to 1000 W/m2, methanol conversion can fall by 6.8–8.9% with air in the annulus, and methanol conversion can decrease by 21.8–28.9% when the glass is removed from the receiver/reactor.
Germination of Seeds of Melanoxylon brauna Schott. under Heat Stress: Production of Reactive Oxygen Species and Antioxidant Activity
Authors: Santos Marcone , Borges Eduardo , Ataíde Glauciana , Souza Genaina
Published: October 2017

In this article, the authors aimed to analyze the physiological and biochemical alterations in Melanoxylon brauna seeds subjected to heat stress. For this, seed germination, electric conductivity (EC), the production of reactive oxygen species (ROS), and the activity of antioxidant enzymes were assessed. Seeds were incubated at constant temperatures of 25, 35, and 45 °C. Independent samples were first incubated at 35 and 45 °C and then transferred to 25 °C after the intervals of 24, 48, 72, and 96 h. To evaluate EC, seeds were soaked for 0, 24, 48, and 72 h, at 25, 35, and 45 °C and then transferred to Erlenmeyer flasks containing 75 mL of deionized water at 25 °C, for 24 h. ROS production and enzyme activity were assessed every 24 h in seeds soaked at the aforementioned temperatures. Germination did not occur at 45 °C. Seeds soaked at 35 °C for 72 h and then transferred to 25 °C showed higher percentages of germination and a higher germination speed. Seed soaking at 45 °C increased peroxide production, which compromised the antioxidant enzyme system due to a reduction in the activity of enzymes APX, POX, and CAT, thus ultimately also compromising the cell membrane system.
Electric Currents along Astrophysical Jets
Authors: Contopoulos Ioannis
Published: October 2017

Astrophysical black holes and their surrounding accretion disks are believed to be threaded by grand design helical magnetic fields. There is strong theoretical evidence that the main driver of their winds and jets is the Lorentz force generated by these fields and their associated electric currents. Several researchers have reported direct evidence for large scale electric currents along astrophysical jets. Quite unexpectedly, their directions are not random as would have been the case if the magnetic field were generated by a magnetohydrodynamic dynamo. Instead, in all kpc-scale detections, the inferred electric currents are found to flow away from the galactic nucleus. This unexpected break of symmetry suggests that a battery mechanism is operating around the central black hole. In the present article, we summarize observational evidence for the existence of large scale electric currents and their associated grand design helical magnetic fields in kpc-scale astrophysical jets. We also present recent results of general relativistic radiation magnetohydrodynamic simulations which show the action of the Cosmic Battery in the vicinity of astrophysical black holes.
How Next-Generation Sequencing Has Aided Our Understanding of the Sequence Composition and Origin of B Chromosomes
Authors: Ruban Alevtina , Schmutzer Thomas , Scholz Uwe , Houben Andreas
Published: October 2017

Accessory, supernumerary, or—most simply—B chromosomes, are found in many eukaryotic karyotypes. These small chromosomes do not follow the usual pattern of segregation, but rather are transmitted in a higher than expected frequency. As increasingly being demonstrated by next-generation sequencing (NGS), their structure comprises fragments of standard (A) chromosomes, although in some plant species, their sequence also includes contributions from organellar genomes. Transcriptomic analyses of various animal and plant species have revealed that, contrary to what used to be the common belief, some of the B chromosome DNA is protein-encoding. This review summarizes the progress in understanding B chromosome biology enabled by the application of next-generation sequencing technology and state-of-the-art bioinformatics. In particular, a contrast is drawn between a direct sequencing approach and a strategy based on a comparative genomics as alternative routes that can be taken towards the identification of B chromosome sequences.
Assessing the Impacts of Climate Change on River Discharge Dynamics in Oueme River Basin (Benin, West Africa)
Authors: Biao Eliézer
Published: October 2017

Understanding the impacts of climate change on water resources is of utmost importance to successful water management and further adaptations strategies. The objective of this paper is to assess the impacts of climate change on river discharge dynamics in Oueme River basin in Benin. To this end, this paper used the distribution based scaling approach to improve usability of regional climate model projections for hydrological climate change impacts studies. Hydrological simulations in Bétérou and Bonou sub-catchments of the Oueme River were carried out with a lumped conceptual hydrological model. The main contribution of this paper is to use the hydrological model based on the least action principle (HyMoLAP), which is designed to minimize uncertainties related to the rainfall-runoff process and scaling law, for this assessment. The bias correction approach allows reducing the differences between the observed rainfall and the regional climate model (HIRHAM5 and RCA4) rainfall data. Corrected and raw HIRHAM5 and RCA4 rainfall data were compared with the observed rainfall using Mean Absolute Error (MAE) and Root Mean Square error (RMSE). The results of the bias correction show a decrease in the RMSE and MAE of the raw HIRHAM5 and RCA4 rainfall data of approximately 91% to 98% in both catchments. The results of the simulation indicate that the HyMoLAP is suitable for modelling river discharge in the Oueme River basin. For the future projection based on RCP4.5 scenarios, the projected mean annual river discharge by using HIRHAM5 and RCA4 in Bétérou and Bonou decrease with the magnitude ranging respectively from −25% to −39% and −20% to −37% in the three time horizons 2020s (2011–2040), 2050s (2041–2070) and 2080s (2071–2100), representing the early, middle and late of 21st century. As regards the future projection based on RCP8.5 scenarios, the projected mean annual river discharge by using HIRHAM5 and RCA4 in Bétérou and Bonou decrease with the magnitude ranging respectively from −15% to −34% and −18% to −36% in the three time horizons. The model uncertainties projections indicated that the entire discharge distribution shifted toward more extreme events (such as drought) compared to the baseline period.
Health in All Policies in South Australia—Did It Promote and Enact an Equity Perspective?
Authors: Van Eyk Helen , Harris Elizabeth , Baum Fran , Delany-Crowe Toni , Lawless Angela , MacDougall Colin
Published: October 2017

Mobilising cross-sectoral action is helpful in addressing the range of social determinants that contribute to health inequities. The South Australian Health in All Policies (SA HiAP) approach was implemented from 2007 to stimulate cross-sector policy activity to address the social determinants of health to improve population wellbeing and reduce health inequities. This paper presents selected findings from a five year multi-methods research study of the SA HiAP approach and draws on data collected during interviews, observation, case studies, and document analysis. The analysis shows that SA HiAP had dual goals of facilitating joined-up government for co-benefits (process focus); and addressing social determinants of health and inequities through cross-sectoral policy activity (outcomes focus). Government agencies readily understood HiAP as providing tools for improving the process of intersectoral policy development, while the more distal outcome-focused intent of improving equity was not well understood and gained less traction. While some early rhetorical support existed for progressing an equity agenda through SA HiAP, subsequent economic pressures resulted in the government narrowing its priorities to economic goals. The paper concludes that SA HiAP’s initial intentions to address equity were only partially enacted and little was done to reduce inequities. Emerging opportunities in SA, and internationally, including the UN Sustainable Development Goals, may revive interest in addressing equity.
Reply to the Letter of Terracini B. et al. “Comment on Piscitelli et al. Hospitalizations in Pediatric and Adult Patients for All Cancer Type in Italy: The EPIKIT Study under the E.U. COHEIRS Project on Environment and Health”. Int. J. Environ. Res. Public Health 2017, 14, 495
Authors: Piscitelli Prisco , Marino Immacolata , Falco Andrea , Rivezzi Matteo , Neglia Cosimo , Della Rosa Giulia , Militerno Giuseppe , Bonifacino Adriana , Rivezzi Gaetano , Romizi Roberto , Miserotti Giuseppe , Montella Maurizio , Bianchi Fabrizio , Marinelli Alessandra , De Donno Antonella , De Filippis Giovanni , Serravezza Giuseppe , Di Tanna Gianluca , Gennaro Valerio , Ascolese Mario , Distante Alessandro , Burgio Ernesto , Colao Annamaria
Published: October 2017

A letter to the IJERPH Editor was submitted by Terracini B. et al. as a comment to our latest paper “Hospitalizations in Pediatric and Adult Patients for all Cancer Type in Italy:[...]
Assessment of SIP Buildings for Sustainable Development in Rural China Using AHP-Grey Correlation Analysis
Authors: Bai Libiao , Wang Hailing , Shi Chunming , Du Qiang , Li Yi
Published: October 2017

Traditional rural residential construction has the problems of high energy consumption and severe pollution. In general, with sustainable development in the construction industry, rural residential construction should be aimed towards low energy consumption and low carbon emissions. To help achieve this objective, in this paper, we evaluated four different possible building structures using AHP-Grey Correlation Analysis, which consists of the Analytic Hierarchy Process (AHP) and the Grey Correlation Analysis. The four structures included the traditional and currently widely used brick and concrete structure, as well as structure insulated panels (SIPs). Comparing the performances of economic benefit and carbon emission, the conclusion that SIPs have the best overall performance can be obtained, providing a reference to help builders choose the most appropriate building structure in rural China.
Turkey National Mesothelioma Surveillance and Environmental Asbestos Exposure Control Program
Authors: Metintaş Selma , Batırel Hasan Fevzi , Bayram Hasan , Yılmaz Ülkü , Karadağ Mehmet , Ak Güntülü , Metintaş Muzaffer
Published: October 2017

Malignant mesothelioma (MM) is an important health problem due to ongoing asbestos exposure. Environmental asbestos exposure leads to a high risk of MM in Turkey. The Turkish Mesothelioma Working Group and the Turkish Public Health Institute designed and performed the Turkey National Mesothelioma Surveillance and Environmental Asbestos Exposure Control Program (TUNMES-EAECP). The aim of this study was to analyze the results of the TUNMES-EAECP. Patients diagnosed with MM (code C45.0–C45.9) between 2008 and 2012 were identified. The “from case to the field” method was used to determine the villages with current or previous asbestos exposure. Special public health teams took soil samples from these villages, which were then examined using an X-ray diffractometer. Direct Standardized Average Annual Mesothelioma Incidence Rate (AMIR) and relative risk (RR) of MM were calculated. Finally, a projection on the incidence of MM between 2013 and 2033 was made. The number of confirmed MM cases was 5617 with a male to female ratio of 1.36. Mean age was 61.7 ± 13.4 (20–96) years. The median survival was eight (95% CI 7.6–8.4) months. Asbestos exposure continues in 379 villages, with 158,068 people still living in high risk areas. The standardized AMIR was 2.33/100,000 per year. The risk of MM was higher in males, in both sexes over the age of 40, in asbestos-containing provinces, and in those where the TUNMES was organized. Among the population with continuing asbestos exposure in rural areas, the number of MM cases between 2013 and 2033 was estimated as 2511. As such, the incidence of MM in Turkey is as high as in industrialized countries. Asbestos exposure in rural areas continues to be a serious problem in Turkey, which obviates the necessity for effective preventive measures.
New Pyrazole-Hydrazone Derivatives: X-ray Analysis, Molecular Structure Investigation via Density Functional Theory (DFT) and Their High In-Situ Catecholase Activity
Authors: Karrouchi Khalid , Yousfi El , Sebbar Nada , Ramli Youssef , Taoufik Jamal , Ouzidan Younes , Ansar M’hammed , Mabkhot Yahia , Ghabbour Hazem , Radi Smaail
Published: October 2017

The development of low-cost catalytic systems that mimic the activity of tyrosinase enzymes (Catechol oxidase) is of great promise for future biochemistry technologic demands. Herein, we report the synthesis of new biomolecules systems based on hydrazone derivatives containing a pyrazole moiety (L1–L6) with superior catecholase activity. Crystal structures of L1 and L2 biomolecules were determined by X-ray single crystal diffraction (XRD). Optimized geometrical parameters were calculated by density functional theory (DFT) at B3LYP/6–31G (d, p) level and were found to be in good agreement with single crystal XRD data. Copper (II) complexes of the compounds (L1–L6), generated in-situ, were investigated for their catalytic activities towards the oxidation reaction of catechol to ortho-quinone with the atmospheric dioxygen, in an attempt to model the activity of the copper containing enzyme tyrosinase. The studies showed that the activities depend on four parameters: the nature of the ligand, the nature of counter anion, the nature of solvent and the concentration of ligand. The Cu(II)-ligands, given here, present the highest catalytic activity (72.920 μmol·L−1·min−1) among the catalysts recently reported in the existing literature.
Bioactivity of Olive Oil Phenols in Neuroprotection
Authors: Angeloni Cristina , Malaguti Marco , Barbalace Maria , Hrelia Silvana
Published: October 2017

Neurological disorders such as stroke, Alzheimer’s and Parkinson’s diseases are associated with high morbidity and mortality, and few or no effective options are available for their treatment. These disorders share common pathological characteristics like the induction of oxidative stress, abnormal protein aggregation, perturbed Ca2+ homeostasis, excitotoxicity, inflammation and apoptosis. A large body of evidence supports the beneficial effects of the Mediterranean diet in preventing neurodegeneration. As the Mediterranean diet is characterized by a high consumption of extra-virgin olive oil it has been hypothesized that olive oil, and in particular its phenols, could be responsible for the beneficial effect of the Mediterranean diet. This review provides an updated vision of the beneficial properties of olive oil and olive oil phenols in preventing/counteracting both acute and chronic neurodegenerative diseases.
Preparation and Characterization of Resorbable Bacterial Cellulose Membranes Treated by Electron Beam Irradiation for Guided Bone Regeneration
Authors: An Sung-Jun , Lee So-Hyoun , Huh Jung-Bo , Jeong Sung , Park Jong-Seok , Gwon Hui-Jeong , Kang Eun-Sook , Jeong Chang-Mo , Lim Youn-Mook
Published: October 2017

Bacterial cellulose (BC) is an excellent biomaterial with many medical applications. In this study, resorbable BC membranes were prepared for guided bone regeneration (GBR) using an irradiation technique for applications in the dental field. Electron beam irradiation (EI) increases biodegradation by severing the glucose bonds of BC. BC membranes irradiated at 100 kGy or 300 kGy were used to determine optimal electron beam doses. Electron beam irradiated BC membranes (EI-BCMs) were evaluated by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, thermal gravimetric analysis (TGA), and using wet tensile strength measurements. In addition, in vitro cell studies were conducted in order to confirm the cytocompatibility of EI-BCMs. Cell viabilities of NIH3T3 cells on 100k and 300k EI-BCMs (100 kGy and 300 kGy irradiated BC membranes) were significantly greater than on NI-BCMs after 3 and 7 days (p < 0.05). Bone regeneration by EI-BCMs and their biodegradabilities were also evaluated using in vivo rat calvarial defect models for 4 and 8 weeks. Histometric results showed 100k EI-BCMs exhibited significantly larger new bone area (NBA; %) than 300k EI-BCMs at 8 weeks after implantation (p < 0.05). Mechanical, chemical, and biological analyses showed EI-BCMs effectively interacted with cells and promoted bone regeneration.
Systemic Inflammation, Oxidative Damage to Nucleic Acids, and Metabolic Syndrome in the Pathogenesis of Psoriasis
Authors: Borska Lenka , Kremlacek Jan , Andrys Ctirad , Krejsek Jan , Hamakova Kvetoslava , Borsky Pavel , Palicka Vladimir , Rehacek Vit , Malkova Andrea , Fiala Zdenek
Published: October 2017

In the pathogenesis of psoriasis, systemic inflammation and oxidative stress play mutual roles interrelated with metabolic syndrome (MetS). This study aims to map the selected markers of inflammation (C-reactive protein (CRP)), oxidative damage to nucleic acids (DNA/RNA damage; 8-hydroxy-2′-deoxyguanosine, 8-hydroxyguanosine, and 8-hydroxyguanine), and the parameters of MetS (waist circumference, fasting glucose, triglycerides, high-density lipoprotein (HDL) cholesterol, diastolic and systolic blood pressure) in a group of 37 patients with psoriasis (62% of MetS) and in 43 healthy controls (42% of MetS). Levels of CRP, DNA/RNA damage, fasting glucose, and triglycerides were significantly elevated in patients. MetS in conjunction with psoriasis was associated with high levels of CRP, significantly higher than in control subjects without MetS. Patients with MetS exhibited further DNA/RNA damage, which was significantly higher in comparison with the control group. Our study supports the independent role of psoriasis and MetS in the increase of CRP and DNA/RNA damage. The psoriasis contributes to an increase in the levels of both effects more significantly than MetS. The psoriasis also diminished the relationship between CRP and oxidative damage to nucleic acids existent in controls.
Comparative Analysis of the Cytology and Transcriptomes of the Cytoplasmic Male Sterility Line H276A and Its Maintainer Line H276B of Cotton (Gossypium barbadense L.)
Authors: Kong Xiangjun , Liu Dongmei , Liao Xiaofang , Zheng Jie , Diao Yong , Liu Yiding , Zhou Ruiyang
Published: October 2017

In this study, the tetrad stage of microspore development in a new cotton (Gossypium barbadense L.) cytoplasmic male sterility (CMS) line, H276A, was identified using paraffin sections at the abortion stage. To explore the molecular mechanism underlying CMS in cotton, a comparative transcriptome analysis between the CMS line H276A and its maintainer line H276B at the tetrad stage was conducted using an Illumina HiSeq 4000 platform. The comparison of H276A with H276B revealed a total of 64,675 genes, which consisted of 59,255 known and 5420 novel genes. An analysis of the two libraries with a given threshold yielded a total of 3603 differentially expressed genes (DEGs), which included 1363 up- and 2240 down-regulated genes. Gene Ontology (GO) annotation showed that 2171 DEGs were distributed into 38 categories, and a Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis showed that 2683 DEGs were classified into 127 groups. Thirteen DEGs were randomly selected and detected by quantitative reverse-transcribed PCR (qRT-PCR), and the results indicated that the transcriptome sequencing results were reliable. The bioinformatic analysis results in conjunction with previously reported data revealed key DEGs that might be associated with the male sterility features of H276A. Our results provide a comprehensive foundation for understanding anther development and will accelerate the study of the molecular mechanisms of CMS in cotton.
Analyzing and Modelling the Corrosion Behavior of Ni/Al2O3, Ni/SiC, Ni/ZrO2 and Ni/Graphene Nanocomposite Coatings
Authors: Nazir Mian Hammad , Khan Zulfiqar Ahmad , Saeed Adil , Bakolas Vasilios , Braun Wolfgang , Bajwa Rizwan , Rafique Saqib
Published: October 2017

A study has been presented on the effects of intrinsic mechanical parameters, such as surface stress, surface elastic modulus, surface porosity, permeability and grain size on the corrosion failure of nanocomposite coatings. A set of mechano-electrochemical equations was developed by combining the popular Butler–Volmer and Duhem expressions to analyze the direct influence of mechanical parameters on the electrochemical reactions in nanocomposite coatings. Nanocomposite coatings of Ni with Al2O3, SiC, ZrO2 and Graphene nanoparticles were studied as examples. The predictions showed that the corrosion rate of the nanocoatings increased with increasing grain size due to increase in surface stress, surface porosity and permeability of nanocoatings. A detailed experimental study was performed in which the nanocomposite coatings were subjected to an accelerated corrosion testing. The experimental results helped to develop and validate the equations by qualitative comparison between the experimental and predicted results showing good agreement between the two.
High Thermal Conductivity of Copper Matrix Composite Coatings with Highly-Aligned Graphite Nanoplatelets
Authors: Simoncini Alessandro , Tagliaferri Vincenzo , Ucciardello Nadia
Published: October 2017

Nanocomposite coatings with highly-aligned graphite nanoplatelets in a copper matrix were successfully fabricated by electrodeposition. For the first time, the disposition and thermal conductivity of the nanofiller has been evaluated. The degree of alignment and inclination of the filling materials has been quantitatively evaluated by polarized micro-Raman spectroscopy. The room temperature values of the thermal conductivity were extracted for the graphite nanoplatelets by the dependence of the Raman G-peak frequency on the laser power excitation. Temperature dependency of the G-peak shift has been also measured. Most remarkable is the global thermal conductivity of 640 ± 20 W·m−1·K−1 (+57% of copper) obtained for the composite coating by the flash method. Our experimental results are accounted for by an effective medium approximation (EMA) model that considers the influence of filler geometry, orientation, and thermal conductivity inside a copper matrix.