bluuebunny/crossref_metadata_2025 huggingface dataset:
Leptomeningeal Collateral Status by Signal Variance in Perfusion Magnetic Resonance Imaging: Association With Initial Stroke Severity and Early Functional Outcome After Thrombectomy
Authors: Helwig Niklas , Seker Fatih , Möhlenbruch Markus A. , Deichmann Ralf , Nöth Ulrike , Gracien René‐Maxime , Hattingen Elke , Wagner Marlies , Seiler Alexander
Published: March 2023

Background

Collaterals are the main determinants of the severity of cerebral ischemia and control the pace of the ischemic tissue damage in acute ischemic stroke. Assessment of collateral status remains a major challenge in stroke imaging. We evaluated a signal variance–based collateral vessel index in perfusion‐weighted imaging (CVIPWI) in terms of its association with initial stroke severity, presence of a mismatch for endovascular thrombectomy (EVT), and early functional outcome in patients with large‐vessel occlusion.

Methods

T2*‐weighted time series from dynamic susceptibility contrast perfusion imaging were processed to calculate the CVIPWI. Ischemic cores were segmented automatically on apparent diffusion coefficient maps. The relationship between collateral status and the fulfilment of mismatch criteria for EVT as well as the association between the CVIPWIand functional outcome in patients undergoing EVT were analyzed. Furthermore, spatial patterns of pial collateralization were investigated.

Results

A total of 156 patients with large‐vessel occlusion were included in the final analysis. Higher CVIPWIand thus better collateral supply was associated with lower baseline National Institutes of Health Stroke Scale and smaller baseline infarct volumes (P=0.022 andP=0.002, respectively), and the CVIPWIvaried significantly among groups according to fulfillment of mismatch criteria for EVT (P<0.001). In patients undergoing EVT (n=105), the CVIPWIwas an independent predictor of favorable functional outcome (modified Rankin scale score of 0–2) at discharge in multivariate analysis (P=0.031). In patients with EVT who had successful reperfusion (n=79), good collateral status was associated with a higher rate of early neurological improvement (P=0.026) and better functional outcome at discharge (P=0.04) in shift analysis.

Conclusion

Signal variance–based CVIPWIrepresents a semiquantitative and objective, thus observer‐independent parameter for direct assessment of collateral status with clinical relevance. Its use may inform clinical decision‐making and may be of interest for clinical stroke trials.
Personal Reflections on Some Early Work in Evolving Strategies in the Iterated Prisoner's Dilemma
Authors: Fogel David B.
Published: March 2023

On the occasion of the 30-year anniversary of the Evolutionary Computation journal, I was invited by Professor Hart to offer some reflections on the article on evolving behaviors in the iterated prisoner's dilemma that I contributed to its first issue in 1993. It's an honor to do so. I would like to thank Professor Ken De Jong, the journal's first editor-in-chief, for his vision in creating the journal, and the editors who have followed and maintained that vision. This article contains some personal reflections on the topic and the field as a whole.
Transcranial Random Noise Stimulation Boosts Early Motion Perception Learning Rather than the Later Performance Plateau
Authors: Liu Na , Wu Di , Wang Yifan , Zhang Pan , Zhang Yinling
Published: March 2023

The effect of transcranial random noise stimulation (tRNS) on visual perceptual learning has only been investigated during early training sessions, and the influence of tRNS on later performance is unclear. We engaged participants first in 8 days of training to reach a plateau (Stage 1) and then in continued training for 3 days (Stage 2). In the first group, tRNS was applied to visual areas of the brain while participants were trained on a coherent motion direction identification task over a period of 11 days (Stage 1 + Stage 2). In the second group, participants completed an 8-day training period without any stimulation to reach a plateau (Stage 1); after that, they continued training for 3 days, during which tRNS was administered (Stage 2). In the third group, participants completed the same training as the second group, but during Stage 2, tRNS was replaced by sham stimulation. Coherence thresholds were measured three times: before training, after Stage 1, and after Stage 2. Compared with sham simulation, tRNS did not improve coherence thresholds during the plateau period. The comparison of learning curves between the first and third groups showed that tRNS decreased thresholds in the early training stage, but it failed to improve plateau thresholds. For the second and third groups, tRNS did not further enhance plateau thresholds after the continued 3-day training period. In conclusion, tRNS facilitated visual perceptual learning in the early stage, but its effect disappeared as the training continued.
Deterrence and Defence: The US Military and International Partnering for Peace in Outer Space
Authors: Sturdevant Rick W.
Published: March 2023

International military alliances have developed to deter potential foes from initiating war and, when deterrence fails, to defeat enemies. From the earliest days of spaceflight, US military leaders have partnered with other nations for various purposes. With the space domain becoming more congested and contested in the early 21st century¸ the US defence establishment has begun expanding and strengthening space-related relationships with like-minded international partners to deter irresponsible, adversarial space behaviour and perpetuate peaceful uses of the outer space domain for civil and commercial purposes.
Post-Election Elite Bargaining and Coalition Formation in the MENA: Lessons from Iraq and Morocco
Authors: Storm Lise , O’Driscoll Dylan
Published: March 2023

This article analyses the dynamics of post-election elite bargaining and coalition formation in the cases of Iraq and Morocco, demonstrating that, despite widely differing contexts, the outcome is often far removed from the election results. Recent works on political parties in the Middle East and North Africa (MENA) have alluded to this state of affairs, but, so far, the scholarship is missing in-depth comparative studies of the intricate dynamics of elite bargaining and coalition formation. Beyond not necessarily connecting to the election results, but rather being rooted in competition over access to patronage resources and power, our comparison demonstrates the negative impact that this state of affairs has on the government’s ability to govern.
The So-called Sempiternalism of the Early Academy
Authors: De Cesaris Giulia
Published: March 2023

It is a well-established opinion in the literature that the immediate circle of Plato’s disciples maintained that the generation of the cosmos described in the Timaeus was to be understood as an illustrative, or educational metaphor. On this account, Plato’s students were the first to hold an eternalist, metaphorical reading of the generation of the world, challenged by the Peripatos. When criticising their position in the De Caelo, however, Aristotle describes Early Academic philosophers as holding the more nuanced view that the world is ‘indestructible and yet generated’ (ἄφθαρτον μὲν […] γενόμενον δέ). Is it possible to make any sense of this formulation and restore a different position for Early Academic philosophers? In this paper, I claim that the standard reading can be challenged and that there is ground to believe that Speusippus and Xenocrates held that the world is generated but everlasting. What they denied having happened in time and said should be understood as an illustrative metaphor is the transition from the absence of an order to order or, in other words, the cosmogonic process itself.
Il proemio di Timeo: struttura, contenuto e funzione
Authors: Ferrari Franco
Published: March 2023

In the proem that precedes the account of the generation of the world, Timaeus provides very important elements for understanding the discourse he is about to delivery. It is a complex text that displays at least three different levels: dialectical, analogical (or metaphorical) and epistemological. In the dialectical section, Timaeus establishes that the sensible universe is a generated reality and as such has a cause; in the metaphorical section, he indicates the analogical schemes he will use to explain the genesis of the cosmos (technical and biological) and the causes on which it depends. Finally, in the epistemological section he explains the reason why this exposition cannot achieve truth but must be content with likeness.
Does the Universe Perceive? On Cosmic Perception in the Timaeus
Authors: Preite Alesia
Published: March 2023

In the present paper, I argue that in order to be in a position to understand what the World Soul thinks about, we need first to answer the question of whether the universe perceives and if so, of what it perceives. I shall first (section 1) lay out the main reasons for suspecting that the universe has perception and some possible objections against this view. I will then (section 2) make a case for my claim that the universe has perception on the basis of my ‘minimalist’ account of perception, which identifies four necessary and jointly sufficient conditions for having an instance of aisthēsis: 1) a body; 2) a soul; 3) affections which cause motion/change in the body and in the soul; 4) the cause of these affections. I will show that the universe composed of a World Body and a World Soul meets all four conditions. On the basis of this, I will claim that one can ascribe (self-) perception to the universe. Finally (section 3), I will suggest that the universe perceives the polyhedra of its own body.
Sombras del eleatismo en la concepción del lenguaje: la refutación de Platón y Aristóteles al monismo lingüístico
Authors: Spangenberg Pilar
Published: March 2023

The article studies two texts closely linked to each other. In the first place, the final lines of Physics I 2, a text in which Aristotle offers a refutation against positions that propose to modify the language to adapt it to a monistic semantics that, from his point of view, involves a reduction of the senses of being analogous to that of the Eleatic thinkers that he has been criticizing. Second, the refutation that the Eleatic Stranger offers to the linguistic monists who “deny the possibility of saying one thing through another” in Plato’s Sophist 251a-254e. It is particularly interesting to illuminate the link between such passages in order to exhibit not only important points of contact in their respective positions regarding the relationship between being and language, but also some significant differences in terms of the doctrines each one of them point to, which denotes a rich and extensive discussion held at the time around the problem of unity and multiplicity in their relationship with language.
Comoclathris acuminata (Pleosporaceae, Pleosporales): A new endophytic species from Indian Himalayas
Authors: MATTOO AROOSA JAN , GHOSH ANIKET , NONZOM SKARMA
Published: March 2023

An interesting endophytic fungus was isolated from the stem of Ephedra gerardiana growing in Ladakh, a cold arid desert and a part of trans-Himalayan region in Northwest India. Based on comprehensive cultural, micro-morphological, and phylogenetic analyses, the isolate was identified as a new species of the genus Comoclathris, proposed herein as C. acuminata. The novelty of the taxon was strongly supported by the concatenated dataset based on nuclear ribosomal internal transcribed spacer (nrITS) and large subunit (nrLSU) regions of DNA. It is characterized by predominantly superficial, dark-brown to black, ostiolate ascomata, cylindro-clavate asci, and muriform ascospores. Comoclathris acuminata differs from other known species of Comoclathris in bearing ascospores with a prominent beak-like or pointed apex. A detailed description, illustrations and phylogenetic results of the new species are provided along with its comparison with the allied species.
Placement of Arthonia rubrocincta in Coniocarpon (lichenized Ascomycota: Arthoniaceae), with an extended range for the species in southeastern North America and the Caribbean
Authors: PERLMUTTER GARY B. , MIRANDA-GONZÁLEZ RICARDO , BUNGARTZ FRANK
Published: March 2023

Arthonia rubrocincta morphologically and anatomically fits the generic concept of Coniocarpon and is here transferred to the latter genus as Coniocarpon rubrocinctum. Specimens from southeastern United States and Bahamas were studied and the range of the species is found to extend north into North Carolina, USA and southeast to the Bahamas. Thatch palm (Coccothrinax argentata) is reported as a new phorophyte. An emended description based on examined material is presented for the species.
Malaxis henanensis (Orchidaceae, Malaxideae), a new species from China
Authors: SHI XIAO-LING , KANG YANG , LIU YU-YING , TU SONG , PENG HONG-JUN , LIU ZHONG-JIAN , PENG DONG-HUI
Published: March 2023

N/A
Diagnostic Value of Convolutional Neural Network Algorithm and High-Sensitivity Cardiac Troponin I Detection Under Machine Learning in Myocardial Infarction
Authors: Lu Xuejun , Jiang Meilian , Lin Ming-Ho
Published: March 2023

Background: It aimed to the diagnosis and examination of acute myocardial infarction (AMI) using echocardiography under improved convolutional neural network (CNN) algorithm and high-sensitivity (Sen) cardiac troponin I (hs-cTnI) detection. The application effect was also evaluated.
Methods: Ninety AMI patients were recruited as the AMI group, and ninety healthy individuals who underwent physical examinations simultaneously were chosen as control (Ctrl) group. Improved CNN algorithm-based echocardiography combined with hs-cTnI detection was applied, and its diagnostic
efficiency was evaluated. Results: The optimal dataset scale (ODS), optimal image scale (OIS) and average precision (AP) of the proposed algorithm were better than those of manual labeling, Canny algorithm, and structured edge (SE) algorithm (P < 0.05). The left ventricular
ejection fraction (LVEF) of the patients in the AMI group was inferior to that of Ctrl group ((55.09±2.78)%) versus (65.01±3.19)%), the left ventricular end-diastolic dimension (LVEDD) was superior to that of Ctrl group ((54.89±6.56) mm vs. (45.98±5.77) mm), and
the cTnI level was also superior to that of Ctrl group ((2.90±0.31) pg/L vs. (0.73±0.42) pg/L) (P < 0.05). The diagnostic Sen (91.89%), specificity (Spe) (81.25%), accuracy (Acc) (90.00%) and consistency (0.56) of echocardiography combined with hs-cTnI were superior
to those of single echocardiography or cTnI detection (P < 0.05).
Cognitive Load and Peace Attitude Influence Cooperative Choices in the Iterated Prisoner’s Dilemma Game
Authors: Fabio Rosa Angela , Marcuzzo Alex , Calabrese Chiara
Published: March 2023

Human society and its development are based on the principle of cooperation. The choice of a cooperative strategy in a context of uncertainty, such as the iterated Prisoner’s Dilemma game, can be influenced by many factors, both individual and situational. However, there is limited evidence regarding how these factors affect strategic choices when players are subjected to cognitive load conditions. The aim of this study was to investigate the effects of situational factors, such as cognitive load, and two individual factors, namely peace attitude and personality, on strategic decision-making. Fifty-six adults participated in the iterated Prisoner’s Dilemma game under two conditions that differed in cognitive load: in the first condition, they had to make decisions about the Prisoner’s Dilemma task with working memory load, while in the second condition, they had to make decisions about the same task without working memory load. Additionally, participants completed the Peace Attitude Scale and the Italian 10-Item Big Five Inventory. The results indicated that both individual and situational factors influenced strategic choices. Specifically, cognitive load increased the cooperative strategy in the iterated Prisoner’s Dilemma game. Furthermore, individual factors influenced strategic choices only in the condition with cognitive load: people with higher levels of peace attitude and conscientiousness tended to be more cooperative than those with lower peace attitude.
Social Media Addiction and Poor Mental Health: Examining the Mediating Roles of Internet Addiction and Phubbing
Authors: Ergün Naif , Özkan Zafer , Griffiths Mark D.
Published: March 2023

Many researchers have examined the potential detrimental role of problematic social media use (often referred as ‘social media addiction’) on mental health. The present study investigated how social media addiction is associated with three components of mental health: depression, anxiety, and stress. In addition, structural equation modeling was used to test the mediating roles of internet addiction and phubbing among a sample of young adults ( N = 603). Results showed that social media addiction was associated with poorer mental health via internet addiction and phubbing. More specifically, associations between social media addiction and stress, and social media addiction and anxiety were explained by both internet addiction and phubbing. The association between social media addiction and depression was explained by internet addiction only. These results remained consistent after controlling for gender, age, frequency of internet use, frequency of social media use, and frequency of smartphone use. These findings extend the extant literature by providing evidence for the dual roles of internet addiction and phubbing in explaining the relationship between social media addiction and poor mental health. Social media addiction did not directly influence poorer mental health but did via internet addiction and phubbing. Therefore, greater awareness of the inter-relationships between technology-based behaviors and their impact on mental health is needed among a wide range of stakeholders, and these inter-relationships need considering in the prevention and treatment of technology-based disorders.
Do Multifamily unit Rents Increase in Response to Light Rail in the Pre-service Period?
Authors: Peng Qiong , Knaap Gerrit‐Jan , Finio Nicholas
Published: March 2023

The effects of transit investments on land and housing values are a longstanding topic of interest in part because the nature and timing of those effects are important for designing anti-displacement and land value capture strategies. For these reasons, we explore whether multifamily unit rents have increased in planned station areas before the Purple Line light rail project in Maryland is operational. We employ a difference-in-difference (DID) approach to explore this question and validate the DID results with a first difference approach. We find that rents for units located within one-half mile of anticipated stations did increase well before transit service is expected to begin, but only for units with two or more bedrooms. We suggest these results imply that anti-displacement and land value capture strategies are warranted and potentially viable, but to be effective they need to be adopted well before transit service begins. Further, our results suggest that in the case of the Purple Line in Maryland, such policies should focus on units located within one-half mile of proposed stations and concentrate on preserving affordable units with two or more bedrooms.
How do Researchers Use Social Media for Science Communication?
Authors: Keng Teck-Ee , Cheng Ming-Yu
Published: March 2023

This study provides an overview of social media usage among researchers in Malaysia and examines factors affecting their use for science communication. The online questionnaire gathered the opinions of 425 researchers from over 20 science disciplines. The descriptive analysis highlighted usage preferences for 10 commonly used social media, while statistical analysis in particular MANOVA and correlation analysis, identified significant factors influencing researchers’ social media use. Up to 62% of respondents believe that social media is more effective in reaching the public, compared to other media. WhatsApp, Facebook, YouTube, Google Scholar, and ResearchGate are routinely used or perceived as beneficial to use. However, Twitter, Instagram, WordPress, and LinkedIn are seldom used because they are less preferred for science communication. Seniority, perceived importance, and perceived credibility are significantly correlated with both intention and actual use. Meanwhile, age and experience are significantly correlated with actual use, but not the intention. Researchers are likely to post and share more on social media if they believe that science communication is important or if they are credible enough to present a scientific consensus. This study offered important insights into the perceptions, concerns, and factors influencing their use for science communication. By determining the perceptions, concerns and motivators affecting researchers, the findings shed light on effective ways to promote researchers’ use of social media to communicate scientific knowledge.
A nomogram based on metabolic profiling to discriminate lung cancer among patients with lung nodules
Authors: Li Chenwei , Chen Zhuo , Zhao Hui , Wang Cuicui , Yu Shujun , Ma Hengde , Wang Qi , Du Xiaohui
Published: March 2023

Objective

To develop a nomogram that discriminates lung cancer from benign lung nodules through metabolic profiling.

Methods

This was a retrospective cohort study that recruited 848 participants who were randomized into training and validation sets at a 7:3 ratio. Clinical characteristics and metabolic profiles were retrieved. Variables in the training set with statistically significant differences were selected for further least absolute shrinkage and selection operator (LASSO) regression. The nomogram was built from 13 variables identified by stepwise regression analysis. Receiver operating characteristic, calibration curve, and decision curve analyses were conducted to evaluate the performance of the nomogram by internal validation.

Results

Thirteen variables were selected through LASSO regression to build the nomogram: age, sex, ornithine, tyrosine, glutamine, valine, serine, asparagine, arginine, methylmalonylcarnitine, tetradecenoylcarnitine, 3-hydroxyisovaleryl carnitine/2-methyl-3-hydroxybutyrylcarnitine, and hydroxybutyrylcarnitine. The nomogram had good discrimination for the training set, with an area under the curve of 0.836 (95% confidence interval: 0.830–0.890). Moreover, the calibration curve with 1000 bootstrap resamples showed that the predicted value coincided well with the actual value. Decision curve analysis described a net benefit superior to baseline within the threshold probability range of 15% to 93%.

Conclusions

The nomogram constructed from metabolic profiling accurately predicted risk of lung cancer.
Sounding and imagining sounds improve visual time perception: Application of the modality effect of time perception
Authors: Wei Shasha , Tian Yu , Yuan Jiajin
Published: March 2023

This study examines whether the modality effect can be used to improve visual time perception. In Experiment 1, we used a time-reproduction task to explore the accuracy (i.e., deviation of reproduced time from veridical time) and precision (i.e., variability of reproduced time) of time perception under auditory, visual, or audiovisual conditions. Results confirmed the existence of a modality effect. Experiments 2a and 2b and Experiment 3 examined whether adding auditory stimuli improves visual time perception. In Experiments 2a and 2b, participants were required to sound when the visual stimuli appeared. Results showed that the addition of sound to visual stimuli perception is associated with higher time perception accuracy than viewing visual stimuli alone. Given that sounding is not always applicable, we conducted Experiment 3, with participants asked to imagine sounds instead of sounding. Results showed that imaginary sounds improved accuracy. However, in Experiments 2a, 2b, and 3, neither sounding nor imagining sounds changed the precision of time perception. The findings of this study indicate that adding auditory stimuli reliably improves the accuracy of visual-time perception, irrespective of whether the sound is real or imagined.
Large-Scale Network Imputation and Prediction of Traffic Volume Based on Multi-Source Data Collection System
Authors: Kwon Donghyun , Lee Changhee , Kang Heechan , Kim Inhi
Published: March 2023

Although newly developed traffic detectors were actively deployed to improve the accuracy and coverage of collecting city-wise traffic state information, the rapid transition of the traffic management system caused the problems of massive data corruption. For the practical application of recovering the missing values, the deep learning-based imputation technique is used, which relies on prediction performance with the consideration of dynamic spatial and temporal characteristics in the traffic state information. However, the existing method requires an assumption that the given data comprise a complete dataset from a single source based on the experiments evaluated on a small scale or long stream of freeways. In this paper, we propose a multi-variable spatio-temporal learning technique based on multi-source traffic state information, which was realized by adopting Attention-based Spatial–Temporal Graph Convolutional Networks (ASTGCN). The proposed imputation method cooperatively aggregates spatial and temporal correlation from two different types of detectors into an integrated framework, which allows us to predict missing volume regardless of the missing rate. Moreover, the study was conducted on a large-scale network that contains the entire road characteristics. Daejeon city has served as a case study to demonstrate the performance, and the results show that the mean absolute error of the proposed method is under 12 vehicles/5 min. Our work indicates that multi-source traffic state information can be utilized to impute city-wide missing traffic volume.
Study on interior noise control of minibus based on structural acoustic radiation
Authors: Xiao Shenghao , He Jie , Xu Gang , Li Yumei , San Yunlong , Cheng Si
Published: March 2023

Aiming at the problem of excessive low-frequency noise inside a minibus, the interior noise control scheme was studied to improve the NVH (Noise, Vibration, and Harshness) performance of the vehicle based on the characteristics of the structural acoustic radiation. With acoustic contribution as the evaluation index, the ability of the structure to radiate noise to the vehicle was studied from the perspective of modal participation and panel contribution. In this study, the legacy finite element model of the vehicle was firstly established, and the model was validated through the modal test of the BIW (Body in White), and the noise transfer function analysis was carried out to identify the critical frequency points. Furthermore, the improved super element method (SEM) was used to establish the super element simulation model of the vehicle, the simulation analysis of the modal contribution and panel contribution was carried out for the critical frequency points, and the panels that provide the main contribution were determined. In addition, a single-factor experimental study was carried out on the position of the critical panel by using the dynamic vibration absorbers with different performance parameters, so as to verify the accuracy of the simulation results of the panel acoustic contribution for the critical frequency. Finally, the structural optimization schemes of the critical panels were designed and verified by experiments. It was indicated that optimizing the acoustic radiation characteristics of the structure by improving the body panel structure to reduce interior noise was feasible.
Design evaluation reviews on the savonius, darrieus, and combined savonius-darrieus turbines
Authors: Tantichukiad Komsan , Yahya Azmi , Mohd Mustafah Anas , Mohd Rafie Azmin Shakrine , Mat Su Ahmad Suhaizi
Published: March 2023

The combination of Savonius and Darrieus turbines had been proposed with the aim to overcome the weaknesses and complement the strengths from each design. This paper gathers relevant information and provided an extensive review on the combined Savonius-Darrieus turbine for both wind and hydro applications. The paper initially reviews the experimental and computational methodologies utilized in previous research in design evaluation of the turbines. The self-starting capability and efficiency of both turbines were the main concern. Following this, investigations were conducted on the possibility of combining the advantages on the two turbines with respect on the design compactness, radius ratios, attachment angles and rotational velocities.
Influencers and Their Salience: Public Perceptions of Individual Agendas on Instagram
Authors: Bantimaroudis Philemon
Published: March 2023

This article draws evidence from a national survey conducted in the Republic of Cyprus. Examining the influencer phenomenon, personal salience is scrutinised as the primary objective of ordinary social media users seeking to draw attention toward themselves. Respondents provided evidence about the types of content they desire in connection with influencers they follow on social media. Furthermore, they provided perceptional evidence about Instagram’s capacity to render individuals salient in social media communities. Finally, the study shows that demographic characteristics and certain types of personal content are associated with influencers’ personal salience.
Digital Games as Media for Teaching and Learning: A Template for Critical Evaluation
Authors: Pötzsch Holger , Hansen Therese Holt , Hammar Emil Lundedal
Published: March 2023

Background

Videogames can be useful tools for teaching and learning. To plan educational uses, potential benefits and possible problematic aspects of specific titles need to be critically assessed by teachers and school leaders prior to implementation.

Theory and Method

Based on game ontological models, we identify salient areas of inquiry in games research and use these to structure a template for evaluation. This way we operationalize foundational games research and put key insights to practical use in the planning and preparation of videogame-based teaching sessions.

Aims

We develop a template for the evaluation of videogames as tools for and objects of teaching and learning to facilitate critical uses of these technologies in schools and other educational settings.

Results

We present a template for critical evaluation to facilitate the use of videogames for educational endeavors. The template distinguishes between videogames as tools for and objects of teaching and learning and is structured along the game ontological dimensions of 1) sign system, 2) rules and mechanics, 3) materiality and 4) players, and includes aspects of both representation and simulation. This way, we disentangle a complex phenomenon and make its components amendable for critical analysis and constructive intervention.

Discussion and Conclusion

We offer illustrating examples for how the template can be used to assess the usability of specific titles in education and discuss advantages and disadvantages. Finally, we suggest steps for implementation and further improvement.
Treating Adolescents With Opioid Use Disorder: A Medication-Assisted Treatment Approach
Authors: Russ Brian R. , D. Gorham Jessica
Published: March 2023

With drug-related overdose death involving opioids hitting record numbers in 2021, clinical mental health counselors (CMHCs) need to be prepared to address the needs of adolescent clients with opioid use disorder (OUD). Adolescent populations with OUD have significant risk factors and poor outcomes and are at elevated risk for an opioid-related overdose due to surges in high-potency opioids. Medication-assisted treatment (MAT) has been an evidenced-based treatment option for adolescents that combines pharmacotherapy and behavioral therapies to treat OUD. This article reviews the adolescent MAT literature and provides clinical implications for CMHCs working with adolescent populations diagnosed with OUD. The medications and behavioral therapies utilized in MAT are highlighted in this article, and a case study provides additional context.
Compound faults diagnosis of rotating machinery via enhanced two-layer sliding correlated kurtosis
Authors: Zhang Chunlin , Hou Wenbo , Wang Yanfeng , Hu Bingbing
Published: March 2023

Compound faults identification from vibration signals is still a challenge for rotating machinery because the multiple periodic impulsive fault signals may oscillate with the same frequency. In this research, a method termed enhanced two-layer sliding correlated kurtosis (TLSCK) is presented for isolating and identifying the compound defects from the monitored data containing strong background noise and compound faults. The method contains two main steps: the dual-tree complex wavelet package transform (DTCWPT) based correlated kurtogram is conducted on the raw monitored data as a frequency filtering step; further, the enhanced TLSCK method is conducted to diagnosis the compound defects from above filtered signals. The output signal of the enhanced TLSCK could locate the occurrence of interested fault impulses, while the unwanted vibration components and residual noise are well eliminated. Both numerically simulated and experimentally measured vibration data of damaged rolling bearings are analyzed via the presented method to test its performance, and the analysis results validate that the proposed method is effective in detecting compound faults of rotating machinery.
Online frequency estimation of periodic disturbance based on FFT algorithm with application in repetitive control
Authors: Farrokhi Moghadam Hassan , Vasegh Nastaran , Seyed Mousavi Sayed Mohsen
Published: March 2023

In this paper, a new adaptive method is proposed for online frequency estimation of a periodic disturbance by the output measurement based on the fast Fourier transform algorithm. The performance of the proposed algorithm is evaluated in the face of time varying frequency, time varying amplitude, non-sinusoidal periodic disturbance, and different plants. Also, the convergence rate of the method is compared by other estimation methods. Then, the online estimation is used in the repetitive controller structure for eliminating periodic disturbances with unknown frequencies. A new analysis is performed on RC and the stability conditions are determined in a theorem. These are illustrated in simulation results. The effectiveness of this method is shown on the application of ϕ-shaped PZT active suspension and it is compared by existing results.
A direct method for wave propagation in elastic fiber composites
Authors: Ru Chong Q
Published: March 2023

A direct method is proposed to study wave dispersion in stiff unidirectional fiber-reinforced elastic random composites. The present model is featured by a modified form of classical elastodynamic equations supplied with a simple differential relation between the displacement field of the composite and the displacement field of the mass center of representative cell. Explicit formulas are derived for the attenuation coefficient and effective phase velocity of in-plane P-waves, SV-waves, and anti-plane SH-waves, respectively. The efficiency and accuracy of the model are demonstrated by comparing predicted results (on the frequency for the maximum attenuation and effective phase velocity at frequencies below the bandgap) with a large group of known data reported in past decades. The proposed model offers a novel general method for dynamics of stiff unidirectional fiber-reinforced elastic random composites.
Pragmatic Deficits in Attention Deficit/Hyperactivity Disorder: Systematic Review and Meta-Analysis
Authors: Kessler Paige B. , Ikuta Toshikazu
Published: March 2023

Introduction:

While poorer pragmatic language skills have been found in attention-deficit/hyperactivity disorder (ADHD) populations, there has been no conclusive evidence of this. We aimed to conduct a meta-analysis of pragmatic language abilities in ADHD populations to definitively demonstrate the extent of pragmatic language deficits in these populations as compared to typically developing (TD) populations.

Methods:

Studies were identified using the search terms ((attention deficit) OR (adhd)) AND (pragmatics), and those studies were screened and reviewed for inclusion criteria, descriptive information, and outcome variables in order to conduct a meta-analysis.

Results:

A total of 14 studies (5,772 participants) met the criteria for quantitative synthesis. Meta-analysis indicated that ADHD populations exhibited significantly poorer pragmatic language skills than TD populations, with a very large overall effect size of −1.55. These results indicate that pragmatic language is significantly impaired in ADHD populations.

Conclusion:

It is suggested that pragmatic language skills may deserve greater surveillance considering the importance of pragmatic language in socio-emotional development, daily life, and academic success.
The use of telemedicine for perioperative pain management during the COVID-19 pandemic
Authors: Xie Anping , Hsu Yea-Jen , Speed Traci J , Saunders Jamia , Nguyen Jaclyn , Khasawneh Amro , Kim Samuel , A Marsteller Jill , M McDonald Eileen , Shechter Ronen , N Hanna Marie
Published: March 2023

Introduction

Using a human factors engineering approach, the Johns Hopkins Personalized Pain Program adopted telemedicine for perioperative pain management in response to the COVID-19 pandemic. This study examines the impact of telemedicine adoption on the quality and outcomes of perioperative pain management.

Methods

A mixed-methods study with a convergent parallel design was conducted. From June 2017 to December 2021, 902 patients participated in the Personalized Pain Program. Quantitative data on daily opioid consumption, pain severity and interference, physical and mental health status, and patient satisfaction and engagement were continuously collected with all patients using chart review and patient surveys. Beginning 23 March 2020, the Personalized Pain Program transitioned to telemedicine. A pre–post quasi-experimental design was used to examine the impact of telemedicine. In addition, qualitative interviews were conducted with 3 clinicians and 17 patients to explore their experience with telemedicine visits.

Results

The monthly number of new patients seen in the Personalized Pain Program did not significantly change before and after telemedicine adoption. Compared to patients having in-person visits before the pandemic, patients having telemedicine visits during the pandemic achieved comparable improvements in daily opioid consumption, pain severity and interference, and physical health status. While telemedicine helped overcome many challenges faced by the patients, the limitations of telemedicine were also discussed.

Conclusion

The COVID-19 pandemic stimulated the use of telemedicine. To facilitate telemedicine adoption beyond the pandemic, future research is needed to examine best practices for telemedicine adoption and provide additional evidence on the effectiveness of telemedicine.
Axial compressive behavior of self-compacting micro-expansive high-strength concrete confined by glass fiber reinforced plastic tube
Authors: Wang Leijia , Zhu Mingqiao , Yue Wenhui , Dong Jiarui
Published: March 2023

To solve the instability of the compression bars in the space truss composed of GFRP tubes, a composite column with high-strength concrete (HSC) confined by glass fiber-reinforced plastic (GFRP) tube was proposed. High-strength self-compacting micro-expansive concrete with a slump greater than 255 mm was produced under normal-temperature curing conditions and confined by GFRP tubes. A mechanical performance test of the GFRP-confined HSC short column under axial compression was performed. The effects of GFRP tube types, concrete expansion agent, constraint effect, ultimate load capacity, and failure mode of the composite structure were discussed and analyzed through the test. A model of the stress-strain response of the GFRP confined HSC column was proposed. The results show that the 45° fiber-wound GFRP tube has a significant restraining effect on the HSC. The stress-strain relationship increases quadratically in a linear fashion. When the composite column was damaged, the GFRP fiber was broken and the concrete was crushed. The ultimate strength was about 1.5 times that of unconstrained HSC columns, and the loading method has less influence on the results. The expansion agent has a significant effect on the deformation performance of the composite column, and its ultimate strain was about 1.4 times that of the composite column without expansion agent.
Translating (in) the margins: The dilemmas, ethics, and politics of a transnational feminist approach to translating in multilingual qualitative research
Authors: Burkhard Tanja , Park Su Jin
Published: March 2023

Drawing on two multilingual qualitative datasets (Korean/English and German/English), this paper examines the dual role and positionalities of two researchers who simultaneously act as translators, as well as the implications of this dual role for multilingual qualitative research. This work is informed by transnational feminist translation studies and transnational feminist approaches to qualitative research, and founded on the two researchers' intimate familiarity with their participants' languages, contexts, and meaning-making processes. Considering the complexity of this familiarity, this work presents unique dilemmas—challenges and opportunities—with respect to translating, representing, and writing about multilingual qualitative data.
For what it’s worth: European Arts & humanities graduates’ employability and their engagement in society
Authors: Comunian Roberta , Jewell Sarah , Sunmoni Adesola , Dent Tamsyn
Published: March 2023

How do European Arts and Humanities (A&H) graduates contribute to their economies and societies? This paper aims to answer this challenging research question by analysing data from the 2018 pilot Eurograduate survey of graduates. The article explores the monitoring of employment dynamics and considers the labour market outcomes of A&H graduates compared to other graduate groups. Our analysis enables an understanding of the utilisation of A&H graduates’ knowledge and skills in the current employment market (job-qualification match) and more specifically, their contribution to legal, social and cultural occupations. The dataset variables enable an exploration of the multiple contributions made by A&H graduates to other aspects of contemporary society. Specifically, we examine graduates’ volunteering activity during and after their degree, alongside other forms of civic engagement, including political and social action. The findings contribute to the broader debate on the value and impact of A&H degrees beyond measurements of graduate earnings.
Configuration design and grasping contact accuracy analysis of a four-finger manipulator used for grasping fragile objects of elliptic cross section
Authors: Wang Dongxia , Wang Liangwen , Xie Hongchang , Wu Zhenzhen , Xie Guizhong , Wang Caidong , Zheng Huadong , Wang Zhuang
Published: March 2023

A type of manipulator configuration with four-fingers is put forward, for grasping fragile hollow workpieces, with adjustable finger length and finger pad shape. Within a certain range, the manipulator can be used to grasp the internal cross section of fragile objects with different size of circular and oval shape. The design idea and structure of the manipulator are introduced, while the join positions between the finger pad and the finger body, as determined by uniform interpolation or Chebyshev interpolation, are comparatively analyzed and researched regarding forming force contact with workpiece. During the process of grasping, the internal forces and deformations between finger pad and workpiece are analyzed, based on a constructed finite element analysis model. The calculation example shows that, under the same grasping parameters, the maximum impact force on the workpiece is reduced by 63%, when the curvature adjustment points for the finger pad are distributed according to the Chebyshev interpolation, compared to their equal spacing distribution. Research has provided a theoretical basis for the design optimization of the finger pad structure and the connection point positions. For using manipulator to grasp objects with different size of circular and oval shape, the working space of the proposed manipulator is studied. The experiments show that, the manipulator structure, as presented in this article, can meet the requirements of relevant tasks.
Efficacy and safety of a triple combination of atezolizumab, bevacizumab plus GEMOX for advanced biliary tract cancer: a multicenter, single-arm, retrospective study
Authors: Wang Kang , Liu Zong-Han , Yu Hong-Ming , Cheng Yu-Qiang , Xiang Yan-Jun , Zhong Jing-Ya , Ni Qian-Zhi , Zhou Li-Ping , Liang Chao , Zhou Hong-Kun , Pan Wei-Wei , Guo Wei-Xing , Shi Jie , Cheng Shu-Qun
Published: March 2023

Background:

Anti-programmed cell death ligand 1/vascular endothelial growth factor inhibition, coupled with chemotherapy, may potentiate antitumor immunity leading to enhanced clinical benefit, but it has not been investigated in advanced biliary tract cancer (BTC).

Objectives:

We investigated the efficacy and safety of atezolizumab, bevacizumab, and gemcitabine plus oxaliplatin (GEMOX) in advanced BTC and explore the potential biomarkers related to the response.

Design:

Multicenter, single-arm, retrospective study.

Methods:

Advanced BTC patients, who received a triple combination therapy at three medical centers between 18 March 2020 and 1 September 2021, were included. Treatment response was evaluated via mRECIST and RECIST v1.1. Endpoints included the overall response rate (ORR), disease control rate (DCR), progression-free survival (PFS), overall survival (OS), and safety. The whole exome sequencing of pathological tissues was conducted for bioinformatic analysis.

Results:

In all, 30 patients were enrolled. The best ORR was 76.7% and the DCR was 90.0%. The median PFS was 12.0 months, and the median OS was not reached. During the treatment, 10.0% (3/30) of patients suffered from ⩾grade 3 treatment-related adverse events (TRAEs). Furthermore, fever (73.3%), neutropenia (63.3%), increased aspartate transaminase and alanine aminotransferase levels (50.0% and 43.3%, respectively) are the most common TRAEs. Bioinformatics analysis revealed patients with altered ALS2CL had a higher ORR.

Conclusion:

The triple combination of atezolizumab, bevacizumab, and GEMOX may be efficacious and safe for patients with advanced BTC. ALS2CL may be a potential predictive biomarker for the efficacy of triple combination therapy.
Advances in immunotherapy for cervical cancer
Authors: Grau-Bejar Juan Francisco , Garcia-Duran Carmen , Garcia-Illescas David , Mirallas Oriol , Oaknin Ana
Published: March 2023

Cervical cancer still represents a major public health problem, being the fourth most common cancer in incidence and mortality in women worldwide. These figures are unacceptable since cervical cancer, an human papillomavirus-related malignancy, is a largely preventable disease by means of well-established screening and vaccination programs. Patients with recurrent, persistent, or metastatic disease unsuitable for curative therapeutic approaches represent a dismal prognosis population. Until recently, these patients were only candidates for cisplatin-based chemotherapy plus bevacizumab. However, the introduction of immune checkpoint inhibitors has revolutionized the treatment landscape of this disease achieving historical overall survival improvements in both the post-platinum and frontline settings. Interestingly, the clinical development of immunotherapy in cervical cancer is currently advancing to earlier stages of the disease, as the locally advanced setting, whose standard of care has not changed in the last decades with still modest outcomes. As more innovative immunotherapy approaches are in clinical early development in advanced cervical cancer, promising efficacy data are emerging that may shape the future of this disease. This review summarizes the main treatment advances carried out in the field of immunotherapy throughout the past years.