bluuebunny/crossref_metadata_2025 huggingface dataset:
DNA methylation accelerated age as captured by epigenetic clocks influences breast cancer risk
Authors: Valencia Celina I. , Saunders Devin , Daw Jennifer , Vasquez Adria
Published: March 2023

Introduction

Breast cancer continues to be the leading form of cancer among women in the United States. Additionally, disparities across the breast cancer continuum continue to increase for women of historically marginalized populations. The mechanism driving these trends are unclear, however, accelerated biological age may provide key insights into better understanding these disease patterns. Accelerated age measured by DNA methylation using epigenetic clocks is to date the most robust method for estimating accelerated age. Here we synthesize the existing evidence on epigenetic clocks measurement of DNA methylation based accelerated age and breast cancer outcomes.

Methods

Our database searches were conducted from January 2022 to April 2022 and yielded a total of 2,908 articles for consideration. We implemented methods derived from guidance of the PROSPERO Scoping Review Protocol to assess articles in the PubMed database on epigenetic clocks and breast cancer risk.

Results

Five articles were deemed appropriate for inclusion in this review. Ten epigenetic clocks were used across the five articles demonstrating statistically significant results for breast cancer risk. DNA methylation accelerated age varied by sample type. The studies did not consider social factors or epidemiological risk factors. The studies lacked representation of ancestrally diverse populations.

Discussion

DNA methylation based accelerated age as captured by epigenetic clocks has a statistically significant associative relationship with breast cancer risk, however, important social factors that contribute to patterns of methylation were not comprehensively considered in the available literature. More research is needed on DNA methylation based accelerated age across the lifespan including during menopausal transition and in diverse populations. This review demonstrates that DNA methylation accelerated age may provide key insights for tackling increasing rates of U.S. breast cancer incidence and overall disease disparities experienced by women from minoritized backgrounds.
Risk factors and conservative therapy outcomes of anastomotic leakage after gastrectomy: Experience of 3,926 patients from a single gastric surgical unit
Authors: He Zhongyuan , Liu Hongda , Zhou Ling , Li Qingya , Wang Linjun , Zhang Diancai , Xu Hao , Xu Zekuan
Published: March 2023

Background

Anastomotic leakage (AL) after gastrectomy is one of the severest postoperative complications and is related to increasing mortality. In addition, no consensus guidelines about strategies of AL treatment have been established. This large cohort study aimed to inspect the risk factors and efficacy of the conservative treatment for AL in patients with gastric cancer.

Methods

We reviewed the clinicopathological data of 3,926 gastric cancer patients undergoing gastrectomy between 2014 and 2021. Results contained the rate, risk factors, and conservative therapy outcomes of AL.

Results

In total, 80 patients (2.03%, 80/3,926) were diagnosed with AL, and esophagojejunostomy was the most frequent AL site (73.8%, 59/80). Among them, one patient (2.5%, 1/80) died. Multivariate analysis indicated that low albumin concentration (P = 0.001), presence of diabetes (P = 0.025), laparoscopic method (P < 0.001), total gastrectomy (P = 0.003), and proximal gastrectomy (P = 0.002) were predicting factors for AL. The closure rate for the conservative treatment of AL in the first month after AL diagnosis was 83.54% (66/79), and the median time from leakage diagnosis to the closure of leakage was 17 days (interquartile range 11–26 days). Low level of plasma albumin (P = 0.004) was associated with late leakage closures. In terms of 5-year overall survival, no significant difference was observed between patients with and without AL.

Conclusion

The incidence of AL after gastrectomy is associated with low albumin concentration, diabetes, the laparoscopic method, and extent of resection. The conservative treatment is relatively safe and effective for the AL management in patients after gastric cancer surgery.
Nadir creatinine as a predictor of renal outcomes in PUVs: A systematic review and meta-analysis
Authors: Meneghesso Davide , Bertazza Partigiani Nicola , Spagnol Rachele , Brazzale Alessandra Rosalba , Morlacco Alessandro , Vidal Enrico
Published: March 2023

Background

Posterior urethral valves (PUVs) represent the most severe pediatric obstructive uropathy, responsible for chronic renal failure in up to 65% of cases and progression to end-stage kidney disease (ESKD) in about 8%–21% of patients. Unfortunately, renal outcomes have poorly improved over time. The key point is to identify patients at risk; thus, several prenatal and postnatal prognostic factors have been analyzed to improve clinical outcomes. Postnatal nadir creatinine seems to accurately predict long-term renal prognosis, but there is no definitive evidence to support this finding.

Objective

We performed a systematic review with meta-analysis to analyze the predictive value of nadir creatinine on long-term renal function in infants with PUVs.

Methods

We conducted this systematic review according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. PubMed and Cochrane Library were systematically searched for studies published from January 2008 to June 2022. All the articles were checked independently by two reviewers in two steps.

Results

A total of 24 articles were screened, and 13 were included for data extraction. Data from 1,731 patients with PUVs were analyzed, with a mean follow-up of 5.5 years; of these, on average, 37.9% developed chronic kidney disease (CKD) and 13.6% developed ESKD. All the articles evaluated nadir creatinine as a predictor of CKD, most using a level of 1 mg/dL, with statistical significance at the 5% level. The relative risk of developing CKD in patients with creatinine values higher than the nadir cutoff considered was 7.69 (95% CI: 2.35–25.17, I2 = 92.20%, p < 0.001).

Conclusions

Nadir creatinine is the best prognostic factor for long-term renal function in patients affected by PUV. A value above the cutoff of 1 mg/dL should be considered a significant predictor for the risk of CKD and ESKD. Further studies are needed to define different nadir creatinine cutoffs for better stratification of the different CKD stages and for the development of reliable scores, which include the association of several variables.
Biomarkers of viral and bacterial infection in rhinovirus pneumonia
Authors: Hartiala Maria , Lahti Elina , Toivonen Laura , Waris Matti , Ruuskanen Olli , Peltola Ville
Published: March 2023

Background

Rhinovirus (RV) is often detected in children hospitalized with pneumonia, but the role of RV in causing pneumonia is still unclear.

Methods

White blood cell count, C-reactive protein, procalcitonin, and myxovirus resistance protein A (MxA) levels were determined from blood samples in children (n = 24) hospitalized with radiologically verified pneumonia. Respiratory viruses were identified from nasal swabs by using reverse transcription polymerase chain reaction assays. Among RV-positive children, the cycle threshold value, RV subtyping by sequence analysis, and the clearance of RV by weekly nasal swabs were determined. RV-positive children with pneumonia were compared to other virus-positive children with pneumonia, and to children (n = 13) with RV-positive upper respiratory tract infection from a separate earlier study.

Results

RV was detected in 6 children and other viruses in 10 children with pneumonia (viral co-detections excluded). All RV-positive children with pneumonia had high white blood cell counts, plasma C-reactive protein or procalcitonin levels, or alveolar changes in chest radiograph strongly indicating bacterial infection. The median cycle threshold value for RV was low (23.2) indicating a high RV load, and a rapid clearance of RV was observed in all. Blood level of viral biomarker MxA was lower among RV-positive children with pneumonia (median 100 μg/L) than among other virus-positive children with pneumonia (median 495 μg/L, p = 0.034) or children with RV-positive upper respiratory tract infection (median 620 μg/L, p = 0.011).

Conclusions

Our observations suggest a true viral-bacterial coinfection in RV-positive pneumonia. Low MxA levels in RV-associated pneumonia need further studies.
Case report: Joint diagnosis and treatment of intrathoracic gastric duplication with a gastric communication in a child by laparoscopy and gastroscopy
Authors: Zhao Huashan , Zhai Yunpeng , Guo Rui , Xu Hongxiu , Lv Longfei , Zhang Shisong
Published: March 2023

Intrathoracic gastric duplication has rarely been reported. A 5-year-old child with gastric duplication located in the left thorax was diagnosed and treated successfully using laparoscopy combined with gastroscopy. Preoperative computed tomography, upper gastrointestinal contrast study, ultrasound, and other imaging methods were insufficient for accurate diagnosis in this case. Laparoscopy combined with gastroscopy is more suitable for the diagnosis and treatment of gastric duplication.
New insights into light spectral quality inhibits the plasticity elongation of maize mesocotyl and coleoptile during seed germination
Authors: Zhao Xiaoqiang , Niu Yining , Hossain Zakir , Zhao Bingyu , Bai Xiaodong , Mao Taotao
Published: March 2023

The plastic elongation of mesocotyl (MES) and coleoptile (COL), which can be repressed by light exposure, plays a vital role in maize seedling emergence and establishment under adverse environmental conditions. Understanding the molecular mechanisms of light-mediated repression of MES and COL elongation in maize will allow us to develop new strategies for genetic improvement of these two crucial traits in maize. A maize variety, Zheng58, was used to monitor the transcriptome and physiological changes in MES and COL in response to darkness, as well as red, blue, and white light. The elongation of MES and COL was significantly inhibited by light spectral quality in this order: blue light > red light > white light. Physiological analyses revealed that light-mediated inhibition of maize MES and COL elongation was closely related to the dynamics of phytohormones accumulation and lignin deposition in these tissues. In response to light exposure, the levels of indole-3-acetic acid, trans-zeatin, gibberellin 3, and abscisic acid levels significantly decreased in MES and COL; by contrast, the levels of jasmonic acid, salicylic acid, lignin, phenylalanine ammonia-lyase, and peroxidase enzyme activity significantly increased. Transcriptome analysis revealed multiple differentially expressed genes (DEGs) involved in circadian rhythm, phytohormone biosynthesis and signal transduction, cytoskeleton and cell wall organization, lignin biosynthesis, and starch and sucrose metabolism. These DEGs exhibited synergistic and antagonistic interactions, forming a complex network that regulated the light-mediated inhibition of MES and COL elongation. Additionally, gene co-expression network analysis revealed that 49 hub genes in one and 19 hub genes in two modules were significantly associated with the elongation plasticity of COL and MES, respectively. These findings enhance our knowledge of the light-regulated elongation mechanisms of MES and COL, and provide a theoretical foundation for developing elite maize varieties with improved abiotic stress resistance.
Improvement of individual learning with mentoring programs for first-year undergraduate students
Authors: Queiruga-Dios Marián , Perez-Araujo Alvaro , de Ávila-Arias Carmen Romero , Queiruga-Dios Araceli
Published: March 2023

Introduction

This study presents a brief analysis of Spanish universities that promote mentoring programs with students. These mentoring programs are divided into different categories depending on the persons (faculty or students) involved in the process and their characteristics (for novice, senior, or international students). The case of the Universidad Francisco de Vitoria is presented, where first-year students from all undergraduate degrees are involved in an annual course where the core part is related to formal mentoring activities.

Methods

This study analyzes undergraduate degree students' outcomes and results from 10 different degrees for a period of 4 academic years (from 2016–2017 to 2019–2020). This first analysis corresponds to students' activities and marks awarded on the assessment of the assigned mentoring tasks related to the competencies of critical thinking, proactivity, personal knowledge (with the objective of acceptance and improvement), and the ability to ask transcendental questions. Then, a reliable and valid survey, conducted every year to all senior students, was used to get feedback from students.

Results

After a quantitative and qualitative analysis of students' results, it was noticed that they become more confident in their studies when they engage in mentoring-based courses and sessions, and this benefits their lives. All this information led to the improvement of the mentoring process.
How active social network site use affects green consumption: A moderated mediation model
Authors: Gong Yanping , Chen Chunyan , Tan Yuxuan , Tang Danni
Published: March 2023

A growing body of literature suggests a link between the usage of social networking sites (SNSs) and green consumption. However, researchers have shown that not all types of SNS usage have the same effect on individuals; therefore, to fully understand the relationship between a particular SNS use type and green consumption, as well as the mechanisms underlying the relationship, more research is required. This study examined a moderated mediation model based on self-awareness theory to explain the “how” and “why” of the relationship between active SNS use and green consumption. An offline survey (N = 210) and an online survey (N = 348) were conducted. The results suggest that active SNS use is positively associated with green consumption via public self-awareness and that impression management motives moderate the mediating role of public self-awareness in the relationship between active SNS use and green consumption. By examining the connection between a specific type of SNS use (active SNS use) and green consumption, our study adds to the body of literature on the causes of green consumption. The results have substantial implications for future research promoting socially responsible consumption behavior.
Determinants of improving the relationship between corporate culture and work performance: Illusion or reality of serial mediation of leadership and work engagement in a crisis period?
Authors: Michulek Jakub , Gajanova Lubica , Krizanova Anna , Nadanyiova Margareta
Published: March 2023

The disease COVID-19 has had an impact on the lives of all people in the world. It also had a great impact on the world economies themselves. There are several scientific publications on the impact of the COVID-19 disease on the work performance of employees, while researchers have focused on less traditional factors such as corporate culture, leadership, or work engagement as well. Corporate culture influences the shared values or behavior of employees at the workplace and creates an environment in which employees work. Through leadership, managers should be able to motivate their employees and thereby ensure their better work performance. It can be assumed that if employees are more engaged, their work performance will be higher. The main goal of the paper is to examine whether corporate culture has an impact on the work performance of employees through the mediators of leadership and work engagement. The data necessary for the goal set in this way were obtained through a questionnaire survey, which was attended by 489 respondents during the year 2022. After the data reliability analysis, by using serial mediation with two mediators, the influence of corporate culture on work performance was verified independently, but also through the mediators of leadership and work engagement. Based on the results, it can be claimed that individual factors have a significant impact on work performance, while the influence of corporate culture mediated by leadership and work engagement was also confirmed. The influence of corporate culture, mediated only by leadership, and the independent influence of corporate culture through work engagement on work performance were also confirmed.
Exploring the impact of the COVID-19 pandemic on perceptual disturbances and dysfunctional eating attitudes and behaviors: A review of the literature
Authors: Monthuy-Blanc Johana , Corno Giulia , Abou Chabake Sara
Published: March 2023

From the outbreak of the novel coronavirus 2019 (COVID-19) a new physical and social distancing environment has changed our lives and, more particularly, the way of perceiving oneself, as well as eating attitudes and behaviors. An increasing number of studies have highlighted a risky scenario in terms of negative perceptions of one’s body as well as disordered eating and eating disorder patterns in both clinical and general population. With regard to this postulate, this literature review posits two main concepts—perceptual disturbances and dysfunctional eating attitudes and behaviors—in the general and (sub-)clinical populations, to provide an understanding of these phenomena during the COVID-19 pandemic. The main objective of this article is to provide a comprehensive and critical review of published scientific literature about perceptual disturbances (i.e., negative body image, body image disturbances, low body esteem) and dysfunctional eating attitudes and behaviors, including disordered eating (e.g., restrictive eating, binge-eating episodes, overeating, emotional eating) and eating disorders features in community (i.e., general population) and clinical and sub-clinical samples worldwide during the COVID-19 pandemic. The PubMed, ScienceDirect, Ebsco, and Google Scholar databases were searched. The initial search produced 42 references. Scientific publications from March 2020 to April 2022 were included, and among the works compiled, only published research articles have been retained. Purely theoretical papers were also excluded. The final selection consisted of 21 studies, covering both community, clinical (i.e., eating disorder population), and sub-clinical samples. The details of the results are discussed taking into consideration the potential impact of changes in the way we perceive ourselves and interact with others (e.g., the popularity of videoconferencing and the over-use of social network sites due to social isolation) as well as changes in eating attitudes and behaviors, physical activity and exercise (e.g., as an emotional response to the insecurity generated by the pandemic context), in community and (sub-)clinical samples. The discussion sheds light on two outcomes: (1) a summary of findings with methodological considerations; (2) an intervention continuum to deal with the consequences of the COVID-19 pandemic; (3) and a final conclusion.
Prospective study on Maresin-1 and cytokine levels in medication-naïve adolescents with first-episode major depressive disorder
Authors: Qiu Tian , Li Xiao , Chen Wanjun , He Jinglan , Shi Lei , Zhou Chenxi , Zheng Anhai , Lei Zhongli , Tang Chenglu , Yu Qingchan , Du Lian , Guo Jiamei
Published: March 2023

Background

Inflammation and immune activation may play a role in the pathological mechanism of Major Depressive Disorder (MDD). Evidence from cross-sectional and longitudinal studies of adolescents and adults has shown that MDD is associated with increased plasma pro-inflammatory cytokines (e.g., IL-1β, IL-6). It has been reported that Specialized Pro-resolving Mediators (SPMs) mediate inflammation resolution, and Maresin-1 can activate the process of inflammation and promote inflammation resolution by promoting macrophage phagocytosis. However, no clinical studies have been conducted to evaluate the relationship between the levels of Maresin-1 and cytokine and the severity of MDD symptomatology in adolescents.

Methods

40 untreated adolescent patients with primary and moderate to severe MDD and 30 healthy participants as the healthy control (HC) group aged between 13 and 18 years old were enrolled. They received clinical and Hamilton Depression Rating Scale (HDRS-17) evaluation and then, blood samples were collected. Patients in the MDD group were re-evaluated for HDRS-17, and blood samples were taken after a six to eight-week fluoxetine treatment.

Results

The adolescent patients with MDD had lower serum levels of Maresin-1 and higher serum levels of interleukin 6 (IL-6) compared with the HC group. Fluoxetine treatment alleviated depressive symptoms in MDD adolescent patients, which was reflected by higher serum levels of Maresin-1 and IL-4 and lower HDRS-17 scores, serum levels of IL-6, and IL-1β. Moreover, the serum level of Maresin-1 was negatively correlated with the depression severity scores on the HDRS-17.

Conclusion

Adolescent patients with primary MDD had lower levels of Maresin-1 and higher levels of IL-6 compared with the HC group, implying that the peripheral level of pro-inflammatory cytokines may be elevated in MDD, resulting in the insufficiency of inflammation resolution. The Maresin-1 and IL-4 levels increased after anti-depressant treatment, whereas IL-6 and IL-1β levels decreased significantly. Moreover, Maresin-1 level negatively correlated with depression severity, suggesting that reduced levels of Maresin-1 promoted the progression of MDD.
Dental service sector and patient-reported oral health outcomes: Modification by trust in dentists
Authors: Song Youngha , Santiago Pedro , Nair Rahul , Cho Hyun-Jae , Brennan David
Published: March 2023

Objective

The study aimed to examine the association between patient-reported oral health outcomes and the dental service sector and trust in dentists. The possible interaction effect of trust on this association was also explored.

Methods

Randomly selected adults aged over 18 years living in South Australia were surveyed using self-administered questionnaires. The outcome variables were self-rated dental health and the evaluation outcome of the Oral Health Impact Profile. The dental service sector and the Dentist Trust Scale were included in bivariate and adjusted analyses with sociodemographic covariates.

Results

Data from 4,027 respondents were analyzed. Unadjusted analysis showed that poor dental health and oral health impact were associated with sociodemographic characteristics, including lower income/education, public dental service, and lower trust in dentists (p < 0.01). Adjusted associations were similarly maintained (p < 0.05) but attenuated with the loss of statistical significance, mainly in the trust tertiles. Lower trust in dentists in the private sector had an interaction effect, with a higher prevalence ratio of oral health impact (prevalence ratio = 1.51; 95% confidence interval, 1.06–2.14; p < 0.05).

Conclusion

Patient-reported oral health outcomes were associated with sociodemographic characteristics, the dental service sector, and trust in dentists.

Implications for public health

The inequality of oral health outcomes between dental service sectors needs to be addressed both independently and in association with covariates including socioeconomic disadvantage.
Healthcare professionals' knowledge, attitude and its associated factors toward electronic personal health record system in a resource-limited setting: A cross-sectional study
Authors: Wubante Sisay Maru , Tegegne Masresha Derese , Melaku Mequannent Sharew , Mengiste Nebyu Demeke , Fentahun Ashenafi , Zemene Wondosen , Fikadie Makida , Musie Basazinew , Keleb Derso , Bewoketu Habtemaryam , Adem Seid , Esubalew Simegne , Mihretie Yohannes , Ferede Tigist Andargie , Walle Agmasie Damtew
Published: March 2023

Introduction

Electronic personal health record (e-PHR) system enables individuals to access their health information and manage it themselves. It helps patient engagement management of health information that is accessed and shared with their healthcare providers using the platform. This improves individual healthcare through the exchange of health information between patients and healthcare providers. However, less is known about e-PHRs among healthcare professionals.

Objective

Therefore, this study aimed to assess Health professionals' Knowledge and attitude and its associated factors toward e-PHR at the teaching hospital in northwest Ethiopia.

Methods

An institution-based cross-sectional study design was used to determine healthcare professionals' knowledge and attitude and their associated factors toward e-PHR systems in teaching hospitals of Amhara regional state, Ethiopia, from 20 July to 20 August 2022. Pretested structured self-administered questionnaires were used to collect the data. Descriptive statistic was computed based on sociodemographic and other variables presented in the form of table graphs and texts. Bivariable and multivariable logistic analyses were performed with an adjusted odds ratio (AOR) and 95% CI to identify predictor variables.

Result

Of the total study participants, 57% were males and nearly half of the respondents had a bachelor's degree. Out of 402 participants, ~65.7% [61–70%] and 55.5% [50–60%] had good knowledge and favorable attitude toward e-PHR systems, respectively. Having a social media account 4.3 [AOR = 4.3, 95% CI (2.3–7.9)], having a smartphone 4.4 [AOR = 4.4, 95% CI (2.2–8.6)], digital literacy 8.8 [(AOR = 8.8, 95% CI (4.6–15.9)], being male 2.7 [AOR = 2.7, 95% CI (1.4–5.0)], and perceived usefulness 4.5 [(AOR = 4.5, 95% CI (2.5–8.5)] were positively associated with knowledge toward e-PHR systems. Similarly, having a personal computer 1.9 [AOR = 1.9, 95% CI (1.1–3.5)], computer training 3.9 [AOR = 3.9, 95% CI (1.8–8.3)], computer skill 19.8 [AOR = 19.8, 95% CI (10.7–36.9)], and Internet access 6.0 [AOR = 6.0, 95% CI (3.0–12.0)] were predictors for attitude toward e-PHR systems.

Conclusion

The findings from the study showed that healthcare professionals have good knowledge and a favorable attitude toward e-PHRs. Providing comprehensive basic computer training to improve healthcare professionals' expectation on the usefulness of e-PHR systems has a paramount contribution to the advancement of their knowledge and attitude toward successfully implementing e-PHRs.
Comparison of different time intervals between laparoscopic cholecystectomy to endoscopic retrograde cholangiopancreatography for patients with cholecystolithiasis complicated by choledocholithiasis
Authors: Hu Lingbo , Shi Xingpeng , Wang Aidong
Published: March 2023

Background

Endoscopic retrograde cholangiopancreatography (ERCP) followed by laparoscopic cholecystectomy (LC) is a common strategy for treatment of patients with gallstones with co-existing stones in the common bile duct (CBD). We conducted this study to compare the effect of different time intervals between ERCP and LC.

Methods

A total of 214 patients who underwent elective LC after ERCP for gallstones and CBD stones between January 2015 and May 2021 were retrospectively reviewed. We compared the hospital stay, operation time, perioperative morbidity, and conversion rate to open cholecystectomy, according to the interval between ERCP and ERCP and LC, namely, one day, 2–3 days, and 4 days or more. A generalized linear model was used to analyze the differences among the groups for outcomes.

Results

There were a total of 214 patients with 52, 80, and 82 patients in group 1, group 2, and group 3 respectively. These groups did not differ significantly in terms of major complications or conversion to open surgery (p = 0.503 and p = 0.358, respectively). The generalized linear model showed that operation times in group 1 and group 2 were similar (odds ratio (OR) 0.144, 95% confidence interval (CI) 12.597, 8.511, p = 0.704), while operation time was significantly longer in group 3 than in group 1 (OR 4.005, 95% CI, 0.217, 20.837, p = 0.045). Post-cholecystectomy hospital stay was similar among the three groups, while post-ERCP hospital stay was significantly longer in group 3 compared with group 1.

Conclusion

We recommend that LC be performed within three days after ERCP to reduce operating time and hospital stay.
Subscapularis tendon tear classification and diagnosis: A systemic review and meta-analysis
Authors: Saremi Hossein , seifrabiei Mohamadali
Published: March 2023

Background

In the current study, we performed a systematic review and meta-analysis regarding the comparison of accuracy, sensitivity, and specificity of the techniques in diagnosing SSC tendon tears. Also, we performed a systematic review of the classification of SSC tendon tears.

Methods

English language, peer-reviewed journal publications from the first date available to March 2022 were extracted by searching PubMed and Web of Science databases. A forest plot was used to graphically show the results of pooled sensitivity, specificity, and accuracy of different diagnostic modalities.

Results

There were six studies on using MRI to diagnose subscapularis tendon tears, five studies on MRI, four studies on clinical examination, one on ultrasonography, and one on CT arthrography. Pooled sensitivity values for MRI, MRA, clinical examination, ultrasonography, and CT arthrography were 0.71 (CI: 0.54; 0.87), 0.83 (0.77; 0.88), 0.49 (0.31; 0.67), 0.39 (0.29; 0.51), and 0.90 (0.72–0.97), respectively. The pooled specificity values for MRI, MRA, clinical examination, ultrasonography, and CT arthrography were 0.93 (CI: 0.89; 0.96), 0.86 (0.75; 0.93), 0.89 (0.73; 0.96), 0.93 (0.88; 0.96), and 0.90 (0.69; 0.98), respectively. The pooled diagnostic accuracy values for MRI, MRA, clinical examination, ultrasonography, and CT arthrography were 0.84 (CI: 0.80; 0.88), 0.85 (0.77; 0.90), 0.76 (0.66; 0.84), 0.76 (0.70; 0.81), and 0.90 (0.78; 0.96), respectively.

Conclusion

According to our systematic review and meta-analysis, MR arthrography was the most accurate in diagnosing subscapularis tears. MR arthrography was the most sensitive, and MRI and ultrasonography were the most specific in detecting subscapularis tears.
Implementing Deep Convolutional Neural Networks for QR Code-Based Printed Source Identification
Authors: Tsai Min-Jen , Lee Ya-Chu , Chen Te-Ming
Published: March 2023

QR codes (short for Quick Response codes) were originally developed for use in the automotive industry to track factory inventories and logistics, but their popularity has expanded significantly in the past few years due to the widespread applications of smartphones and mobile phone cameras. QR codes can be used for a variety of purposes, including tracking inventory, advertising, electronic ticketing, and mobile payments. Although they are convenient and widely used to store and share information, their accessibility also means they might be forged easily. Digital forensics can be used to recognize direct links of printed documents, including QR codes, which is important for the investigation of forged documents and the prosecution of forgers. The process involves using optical mechanisms to identify the relationship between source printers and the duplicates. Techniques regarding computer vision and machine learning, such as convolutional neural networks (CNNs), can be implemented to study and summarize statistical features in order to improve identification accuracy. This study implemented AlexNet, DenseNet201, GoogleNet, MobileNetv2, ResNet, VGG16, and other Pretrained CNN models for evaluating their abilities to predict the source printer of QR codes with a high level of accuracy. Among them, the customized CNN model demonstrated better results in identifying printed sources of grayscale and color QR codes with less computational power and training time.
A Fast Path Planning Method of Seedling Tray Replanting Based on Improved Particle Swarm Optimization
Authors: Sun Erjie , Xiao Zhang , Tan Yu
Published: March 2023

In the factory nursery, qualified seedlings can be used to replant unqualified seedlings or missing seedlings in the seedling tray through automatic transplanters. Due to the random positions of unqualified and missing seedlings, the end effector of the automatic replanting machine spends substantial time shuttling between the supply tray and the target tray to complete the replanting task. Therefore, we proposed a fast path planning method based on improved particle swarm optimization and compared it with the fixed sequence method and genetic algorithm in experiments with different replanting numbers in different tray types. The experiment shows that the improved particle swarm optimization algorithm and genetic algorithm can shorten the length of the replantation path by about 20% compared with the fixed sequence method, and the running time of the improved particle swarm optimization algorithm is 57.63% less than the genetic algorithm on average. The replanting path optimization method based on improved particle swarm optimization designed in this research can significantly optimize the length and time of the replanting path of the seedling tray, improve the efficiency of the replanting operation, and meet the real-time requirements.
Vegetation Characteristics of the Main Grassland Types in China Respond Differently to the Duration of Enclosure: A Meta-Analysis
Authors: Liu Cheng , Li Hui , Liu Kesi , Shao Xinqing , Huang Jing , Siri Muji , Feng Changliang , Yang Xiaomeng
Published: March 2023

Enclosure is one of the useful measures to protect and restore degraded grasslands, and it is widely used around the world. The vegetation characteristics of grasslands directly reflect the recovery status of degraded grasslands; however, conflicting results of plant traits were continually achieved in the numerous on-site studies of enclosure in the last two decades. It is necessary to conduct a systematic assessment to find a general conclusion for the effects of enclosure on different grasslands. Studies on the enclosure grasslands in China were taken as the objects to refine the relationships between grassland vegetation characteristics and enclosure measures using meta-analysis. Enclosure had positive effects on the restoration of vegetation coverage, aboveground and belowground biomass, and diversity of degraded grasslands. Different vegetation characteristics and grassland types showed different responses to enclosure duration. The vegetation productivity reached a maximum in the 11–15 years of enclosure for alpine grasslands and typical steppe grasslands, 6–10 years for desert grasslands, and more than 15 years of enclosure for meadow grasslands. Plant species diversity reached the peak values when alpine grasslands and typical steppe grasslands were enclosed approximately 10 years, desert grasslands approximately 11–15 years, and meadow grasslands approximately 5 years. These results indicated that the management strategies of enclosed grasslands should be adjusted reasonably according to the types and the management objectives of grasslands in order to maintain or even improve the condition and services of grassland ecosystems.
Relationship between Phosphorus and Nitrogen Concentrations of Flax
Authors: Xie Yaping , Li Lingling , Wang Limin , Zhang Jianping , Dang Zhao , Li Wenjuan , Qi Yanni , Zhao Wei , Dong Kongjun , Wang Xingrong , Zhang Yanjun , Zeng Xiucun , Zhou Yangchen , Wang Xingzhen , Shi Linrong , Wu Gang
Published: March 2023

Tools quantifying phosphorus (P) status in plants help to achieve efficient management and to optimize crop yield. The objectives of this study were to establish the relationship between P and nitrogen (N) concentrations of flax (Linum usitatissimum L.) during the growth season to determine the critical P concentration for diagnosing P deficiency. Field experiments were arranged as split plots based on a randomized complete block design. Phosphorus levels (0, 40, 80, 120, and 160 kgP2O5 ha−1) were assigned to the main plots, and cultivars (Dingya 22, Lunxuan 2, Longyaza 1, Zhangya 2, and Longya 14) were allocated to the subplots. Shoot biomass (SB) and P and N concentrations were determined at 47, 65, 74, 98, and 115 days after emergence. Shoot biomass increased, while P and N concentrations and the N:P ratio declined with time in each year. The P concentration in respect of N concentration was described using a liner relationship (P = 0.05, N + 1.68, R2 = 0.76, p < 0.01) under non-limiting P conditions, in which the concentrations are expressed in g kg−1 dry matter (DM). The N:P ratio was fitted to a second-order polynomial equation (N:P = 11.56 × SB−0.1, R2 = 0.71, p = 0.03), based on the SB of flax. This research first developed a predictive model for critical P concentration in flax, as a function of N concentration in shoots of flax. The critical P concentration can be used as a promising alternative tool to quantify the degree of P deficiency of flax during the current growing season.
Integration of the Microbiome, Metabolome and Transcriptome Reveals Escherichia coli F17 Susceptibility of Sheep
Authors: Chen Weihao , Lv Xiaoyang , Cao Xiukai , Yuan Zehu , Wang Shanhe , Getachew Tesfaye , Mwacharo Joram M. , Haile Aynalem , Quan Kai , Li Yutao , Sun Wei
Published: March 2023

Escherichia coli (E. coli) F17 is one of the most common pathogens causing diarrhea in farm livestock. In the previous study, we accessed the transcriptomic and microbiomic profile of E. coli F17-antagonism (AN) and -sensitive (SE) lambs; however, the biological mechanism underlying E. coli F17 infection has not been fully elucidated. Therefore, the present study first analyzed the metabolite data obtained with UHPLC-MS/MS. A total of 1957 metabolites were profiled in the present study, and 11 differential metabolites were identified between E. coli F17 AN and SE lambs (i.e., FAHFAs and propionylcarnitine). Functional enrichment analyses showed that most of the identified metabolites were related to the lipid metabolism. Then, we presented a machine-learning approach (Random Forest) to integrate the microbiome, metabolome and transcriptome data, which identified subsets of potential biomarkers for E. coli F17 infection (i.e., GlcADG 18:0-18:2, ethylmalonic acid and FBLIM1); furthermore, the PCCs were calculated and the interaction network was constructed to gain insight into the crosstalk between the genes, metabolites and bacteria in E. coli F17 AN/SE lambs. By combing classic statistical approaches and a machine-learning approach, our results revealed subsets of metabolites, genes and bacteria that could be potentially developed as candidate biomarkers for E. coli F17 infection in lambs.
Plasma and Synovial Fluid Cell-Free DNA Concentrations Following Induction of Osteoarthritis in Horses
Authors: Panizzi Luca , Dittmer Keren E. , Vignes Matthieu , Doucet Jennie S. , Gedye Kristene , Waterland Mark R. , Rogers Chris W. , Sano Hiroki , McIlwraith C. Wayne , Riley Christopher B.
Published: March 2023

Biomarkers for osteoarthritis (OA) in horses have been extensively investigated, but translation into clinical use has been limited due to cost, limited sensitivity, and practicality. Identifying novel biomarkers that overcome these limitations could facilitate early diagnosis and therapy. This study aimed to compare the concentrations of synovial fluid (SF) and plasma cell-free DNA (cfDNA) over time in control horses with those with induced carpal OA. Following an established model, unilateral carpal OA was induced in 9 of 17 healthy Thoroughbred fillies, while the remainder were sham-operated controls. Synovial fluid and plasma samples were obtained before induction of OA (Day 0) and weekly thereafter until Day 63, and cfDNA concentrations were determined using fluorometry. The SF cfDNA concentrations were significantly higher for OA joints than for sham-operated joints on Days 28 (median 1430 μg/L and 631 μg/L, respectively, p = 0.017) and 63 (median 1537 μg/L and 606 μg/L, respectively, p = 0.021). There were no significant differences in plasma cfDNA between the OA and the sham groups after induction of carpal OA. Plasma cfDNA measurement is not sufficiently sensitive for diagnostic purposes in this induced model of OA. Synovial fluid cfDNA measurement may be used as a biomarker to monitor early disease progression in horses with OA.
Short-Term Microplastic Exposure Impairs Cognition in Hermit Crabs
Authors: Crump Andrew , Aiken Catherine , Cunningham Eoghan M. , Arnott Gareth
Published: March 2023

We tested whether acute microplastic exposure impacts information gathering and processing (cognition) in hermit crabs (Pagurus bernhardus). For five days, we kept 51 hermit crabs in tanks containing either polyethylene microspheres (n = 27) or no plastic (n = 24). We then transferred individuals into an intermediate-quality shell and presented them with two vials containing either a better or worse shell. Because touching both shell vials required an equivalent behavioural response, this design controlled for general activity. Plastic-exposed hermit crabs were less likely and slower than controls to touch the better shell vial, instead preferring the worse shell vial. Microplastics, therefore, impaired assessments and decision-making, providing direct evidence of acute microplastic exposure disrupting hermit crab cognition.
Integrative Analysis of Blood Transcriptomics and Metabolomics Reveals Molecular Regulation of Backfat Thickness in Qinchuan Cattle
Authors: Yu Hengwei , Raza Sayed Haidar Abbas , Pan Yueting , Cheng Gong , Mei Chugang , Zan Linsen
Published: March 2023

A crucial goal of reducing backfat thickness (BFT) is to indirectly improve feed conversion efficiency. This phenotype has been reported in certain papers; however, the molecular mechanism has yet to be fully revealed. Two extreme BFT groups, consisting of four Qinchuan cattle, were chosen for this study. We performed metabolite and transcriptome analyses of blood from cattle with a high BFT (H-BFT with average = 1.19) and from those with a low BFT (L-BFT with average = 0.39). In total, 1106 differentially expressed genes (DEGs) and 86 differentially expressed metabolites (DEMs) were identified in the extreme trait. In addition, serum ceramide was strongly correlated with BFT and could be used as a potential biomarker. Moreover, the most notable finding was that the functional genes (SMPD3 and CERS1) and metabolite (sphingosine 1-phosphate (S1P)) were filtered out and significantly enriched in the processes related to the sphingolipid metabolism. This investigation contributed to a better understanding of the subcutaneous fat depots in cattle. In general, our results indicated that the sphingolipid metabolism, involving major metabolites (serum ceramide and S1P) and key genes (SMPD3 and CERS1), could regulate BFT through blood circulation.
Optimizing a U-Shaped Conveyor Assembly Line Balancing Problem Considering Walking Times between Assembly Tasks
Authors: Kuo Yiyo , Chen Ssu-Han , Yang Taho , Hsu Wei-Chen
Published: March 2023

This research deals with a U-shaped assembly line balancing problem in which items are fixed on the conveyor. Operators execute the assembly tasks without removing items from the conveyor as the assembly items are assumed to be unsuitable for manual handling. The operators have to walk beside the conveyor at the same speed as the conveyor while they execute assembly tasks. If the operators want to assemble other items, they may have to walk to other positions at their normal walking speed. Therefore, the cycle time of an operator should include assembly times and walking times between assembly tasks. In this research, a mathematical model of the proposed U-shaped conveyor assembly line balancing problem was developed. Given a number of operators, the mathematical model can optimize the sequence of tasks and allocation of tasks to workstations using the commercial software LINGO 17. Because LINGO 17 requires a long computing time, simulated annealing (SA), which can accept worse new solutions in the search procedure, is proposed. The experimental results show that the proposed SA can optimize the problem efficiently.
Agent-Based Virtual Machine Migration for Load Balancing and Co-Resident Attack in Cloud Computing
Authors: Xu Biao , Lu Minyan
Published: March 2023

The majority of cloud computing consists of servers with different configurations which host several virtual machines (VMs) with changing resource demands. Additionally, co-located VMs are vulnerable to co-resident attacks (CRA) in a networked environment. These two issues may cause uneven resource usage within the server and attacks on the service, leading to performance and security degradation. This paper presents an Agent-based VM migration solution that can balance the burden on commercially diverse servers and avoid potential co-resident attacks by utilizing VM live migrations. The Agent’s policies include the following: (i) a heuristic migration optimization policy to select the VMs to be migrated and the matching hosts; (ii) a migration trigger policy to determine whether the host needs to relocate the VMs; (iii) an acceptance policy to decide if the migration request should be accepted; and (iv) a balancer heuristic policy to make the initial VM allocation. The experiments and analyses demonstrate that the Agents can mitigate CRA in a distributed way to mitigate the associated risks while achieving acceptable load balancing performance.
Displacement Analyses of Main Structure of Parallel Pit Excavation and Analysis of Countermeasures
Authors: Cui Xiangyang , Li Zhaoping , Guo Fei , Han Xuegang , Song Jianping
Published: March 2023

To solve the impact on the pre-existing main structure due to the need for early traffic restoration of urban roads within the cross-hub and the difficulty of co-ordinating a construction plan among groups of pits, a construction method combining TD and BU was proposed. By establishing a three-dimensional finite difference method (FDM) of parallel pit excavation considering the small strain constitutive model of the strata, the influence of four different excavation schemes on the pre-existing main structs is studied. The results of the study show that: (1) the asynchronous excavation of the pit on both sides of the cover excavation area causes additional deformation of the steel pipe structs; sequential excavation produces the greatest additional deformation of the steel tube columns, followed by staggered excavation and the least simultaneous excavation; (2) the middle 1 slab enhances the overall stiffness of the main structure in the cover excavation area, reducing the additional deformation caused by the unsynchronized excavation of the pit, with the maximum horizontal deformation of 5.8 mm, a reduction of 61%; (3) the greater the depth of excavation and the closer the distance from the pit, the more obvious the deformation of the steel pipe column; and (4) the function relationship between δhm/H and the relative stiffness coefficient Rd was obtained by fitting, and the maximum controlled mis-step spacing of the foundation excavation on both sides was 4.3 m when the middle 1 floor slab was cast.