bluuebunny/crossref_metadata_2025 huggingface dataset:
Effectiveness of Securing Central Venous Catheters with Topical Tissue Adhesive in Patients Undergoing Cardiac Surgery: A Randomized Controlled Pilot Study
Authors: Prachanpanich Naruemol , Morakul Sunthiti , Kiatmongkolkul Napanont
Published: December 2020

Background: Central venous catheters (CVCs) play an important role during cardiac surgery. Topical tissue adhesives form a thin film of coating that becomes bound to keratin in the epidermis. The advantage of this “super glue” lies in its antimicrobial activity. This study aimed to evaluate fixation of CVCs with topical tissue adhesive in patients (prone to bleed) undergoing cardiac surgery regarding its ability to reduce the incidence of pericatheter leakage.Methods: This randomized controlled trial included 150 patients >15 years of age who were (1) scheduled to undergo elective cardiac surgery, (2) required CVC insertion at the internal jugular vein, and (3) scheduled for transfer postoperatively to the cardiac intensive care unit. We randomly assigned patients to a topical tissue adhesive group (TA) or a standard control group (SC). The primary outcome was a change in dressing immediately postoperatively due to pericatheter blood oozing. Secondary outcomes were the number of dressings, total dressings per catheter day, and composite outcome of catheter failure within 3 days. Both intention-to-treat and per-protocol analyses were performed. Seven patients violated the protocol (three TA patients and four SC patients).Results: Regarding the primary outcome, the SC group exhibited a significantly increased incidence of dressing change immediately postoperatively due to pericatheter leakage compared with the TA group in both the intention-to-treat analysis (5.33% vs 18.67%, RR 0.25 [95% CI 0.08 to 0.79], P = 0.012) and the per-protocol analysis (5.56% vs 16.90%, RR 0.289 [95% CI 0.09 to 0.95], P = 0.031). No significant differences were noted in the number of dressings, total dressings per catheter day, or composite outcome of catheter failure within 3 days between the two groups. Multiple logistic regression analysis was performed to adjust baseline characteristics that were different in the per-protocol analysis. The results showed that the risk ratio of immediate postoperative dressing change in TA patients was 0.25 compared to the SC group ([95% CI 0.07 to 0.87], P = 0.029) in the per-protocol analysis.Conclusion: The use of a topical tissue adhesive can reduce the incidence of immediate postoperative pericatheter blood oozing.Trial registration: TCTR20180608004, retrospectively registered on June 06, 2018. http://www.clinicaltrials.in.th/index.php?tp=regtrials&menu=trialsearch&smenu=fulltext&task=search&task2=view1&id=3610
Pilot Randomised Evaluation of Singing in Dementia (PRESIDE): protocol for a two-arm, parallel group randomised controlled feasibility study with waiting-list control
Authors: Dowson Becky , Schneider Justine , Guo Boliang , Bath Philip M , McDermott Orii , Haywood Lee J , Orrell Martin
Published: December 2020

Background As the number of people living with dementia grows, so does the need to provide them with adequate psychosocial support. Many people with dementia live at home with family carers, who also require social and emotional support to cope with their role. Community group singing has received attention for its potential to support people with dementia and their carers. It is postulated that singing can improve cognitive function, strengthen the bonds between care partners, and help to establish social support networks. However, there is a lack of rigorous evidence of singing’s benefits for this population. This study aims to test the feasibility of a randomised controlled trial of community singing in dementia, to pave the way for a larger, conclusive study. Methods The PRESIDE study is designed as a two-arm, parallel group randomised trial with a waiting list control. Dyads consisting of a person with dementia (n=80) and their carer (n=80) will be recruited. Each dyad will be randomised either to attend 10 weeks of community group singing sessions straight away, or to wait for three months before attending the sessions. The singing sessions will be led by experienced professional musicians and will last about 90 minutes, including time for socialising. The primary outcome of this study is the attainment of feasibility criteria around recruitment, retention and the acceptability of the waiting list control. Secondary outcomes include the quality of life, mood, cognition, and musical engagement of the person with dementia, and quality of life, mood, and experiences/challenges of the carer. These data will be collected during home visits at baseline, and three and six months post-baseline. Discussion Despite growing public interest in the positive effects of singing, and encouraging findings from qualitative and non-randomised quantitative studies, there is a lack of rigorous evidence. This is the first randomised controlled trial of community group singing for people with dementia in Europe, to our knowledge. If the results favour a full trial, conclusively demonstrating the effectiveness of group singing could positively affect the opportunities available to community-dwelling people with dementia and their carers.
Intimate partner violence during pregnancy and neonatal mortality in Eastern Ethiopia: A population based matched case-control study
Authors: Ashenafi Wondimye , Mengistie Bezatu , Egata Gudina , Berhane Yemane
Published: December 2020

Background: Intimate partner physical, sexual and psychological abuses and controlling behaviors against pregnant women are common in low-income settings. In Ethiopia, different forms of intimate partner violence (IPV) during pregnancy is highly prevalent and neonatal mortality has been one of the health indicators that did not show significant improvement in the country despite a significant reduction in under-five mortality. We aimed to examine whether exposure to different forms of IPV during pregnancy is associated with neonatal mortality.Methods: A population based matched case–control study was conducted from January to October 2018 in Eastern Ethiopia. A sample of 103 cases (biological mothers of deceased neonates) and 412 controls (biological mothers of survived neonates) were included in the study. The cases and controls were matched for date of birth, sex of the newborn and place of residences. Conditional logistic regression analysis was performed to assess association between IPV during pregnancy and neonatal mortality, controlling for selected potential confounders.Results: After controlling for potential confounding factors (pregnancy and obstetric as well socio-demographic characteristics) sexual violence during pregnancy [Adjusted Odds Ratio (AOR) =3.20: 95% CI: 1.09-9.33] and husband/partner controlling behavior (AOR=2.42: 95% CI: 1.06-5.51) were found to be significantly associated with neonatal mortality. Psychological and physical violence during pregnancy did not show significant associations with the neonatal mortality.Conclusion: Neonatal mortality is strongly associated with intimate partner sexual violence and controlling behaviors during pregnancy. Involving men in maternal health programs is imperative to address issues of violence in pregnancy and promote maternal well being and child health.
Modified silicone stent for the treatment of post-surgical bronchopleural fistula: A clinical observation of 17 cases
Authors: Zeng Junli , Wu Xuemei , Chen Zhide , Zhang Meihua , Ke Mingyao
Published: December 2020

Background: Bronchopleural fistula is a rare but life-threatening event with limited therapeutic options. We aimed to investigate the efficacy and safety of the modified silicone stent in patients with post-surgical bronchopleural fistula.Methods: Between March 2016 and April 2020, we retrospectively reviewed the records of 17 patients with bronchopleural fistula and who underwent bronchoscopic placement of the Y-shaped silicone stent. The rate of initial success, clinical success and clinical cure, and complications were analyzed.Results: Stent placement was successful in 16 patients in the first attempt (initial success rate: 94.1%). The median follow-up time was 107 (range, 5-431) days. All patients achieved amelioration of respiratory symptoms. The clinical success rate was 76.5%. Of the 14 patients with empyema, the daily drainage was progressively decreased in 11 patients, and empyema completely disappeared in six patients. Seven stents were removed during follow-up: four (26.7%) for the cure of fistula, two for severe proliferation of granulomatous tissue and one for stent dislocation. No severe adverse events (i.e. massive hemoptysis, suture dehiscence) took place. Seven patients died (due to progression of malignancy, uncontrolled infection, myocardial infarction and left heart failure).Conclusions: The modified silicone stent may be an effective and safe option for patients with post-surgical bronchopleural fistula patients in whom conventional therapy is contraindicated.
Maternal Death Surveillance and Response in Tanzania: Comprehensiveness of narrative summaries and action points from maternal death reviews
Authors: Said Ali , Pembe Andrea B. , Massawe Siriel , Hanson Claudia , Malqvist Mats
Published: December 2020

Background Maternal deaths reviews are proposed as one strategy to address high maternal mortality in low and middle-income countries, including Tanzania. Review of maternal deaths relies on comprehensive documentation of medical records that can reveal the sequence of events leading to death. The World Health Organization’s and the Tanzanian Maternal Death and Surveillance (MDSR) system propose the use of narrative summaries during maternal death reviews for discussing the case to categorize causes of death, identify gaps in care and recommend action plans to prevent deaths. Suggested action plans are recommended to be Specific, Measurable, Attainable, Relevant and Time bound (SMART). To identify gaps in documenting information and developing recommendations, comprehensiveness of written narrative summaries and action plans were assessed. Methods A total of 76 facility maternal deaths that occurred in two regions in Southern Tanzania in 2018 were included for analysis. Using a prepared checklist from Tanzania 2015 MDSR guideline, we assessed comprehensiveness by presence or absence of items in four domains, each with several attributes. These were socio-demographic characteristics, antenatal care, referral information and events that occurred after admission. Less than 75% completeness of attributes in all domains was considered poor while 95% and above were good/comprehensive. Action plans were assessed by application of SMART criteria and according to the place of planned implementation (community, facility or higher level of health system).Results Almost half of narrative summaries (49%) scored poor, and only1% scored good/comprehensive. Summaries missed key information such as demographic characteristics, time between diagnosis of complication and commencing treatment (65%), investigation results (47%), summary of case evolution (51%) and referral information (47%). A total of 285 action points were analysed. Most action points, 242(85%), recommended strategies to be implemented at health facilities and were mostly about service delivery, 120(42%). Only 42% (32/76) of the action points were deemed to be SMART.Conclusions Abstraction of information to prepare narrative summaries used in the MDSR system is inadequately done. Most recommendations were unspecific with a focus on improving quality of care in health facilities
Acceptability of a Complex Team-based Quality Improvement Intervention for Transient Ischemic Attack
Authors: Damush Teresa M , Penney Lauren S. , Miech Edward J. , Rattray Nicholas A. , Baird Sean A. , Cheatham Ariel J. , Austin Charles , Sexson Ali , Myers Laura J. , Bravata Dawn M.
Published: December 2020

Background: The Protocol-guided Rapid Evaluation of Veterans Experiencing New Transient Neurologic Symptoms (PREVENT) program was a complex quality improvement (QI) intervention targeting transient ischemic attack (TIA) evidence-based care. The aim of this study was to evaluate program acceptability among the QI teams and factors associated with degrees of acceptability.Methods: QI teams from six Veterans Administration facilities participated in active implementation for a one-year period. We employed mixed methods to evaluate program acceptability. Multiple data sources were collected over implementation phases and triangulated for this evaluation. First, we conducted 30 onsite, semi-structured interviews during active implementation with 35 participants at 6 months; 27 interviews with 28 participants at 12 months; and 19 participants during program sustainment. Second, we collected participant automated response survey data during the team kick-off meeting. Third, we conducted debriefing meetings after onsite visits and monthly virtual collaborative calls. All interviews and debriefings were audiotaped, transcribed, and de-identified. De-identified files were qualitatively coded and analyzed for common themes and acceptability patterns. We conducted mixed-methods matrix analyses comparing acceptability by satisfaction ratings and by the Theoretical Framework of Acceptability (TFA). Results: Overall, the QI teams reported the PREVENT program was acceptable. At pre-implementation phase, reviewing quality data, team brainstorming solutions and development of action plans were rated as most useful during the team kickoff meetings. Program acceptability perceptions varied over time across active implementation and after teams accomplished actions plans and moved into sustainment. We observed team acceptability growth over a year of active implementation in concert with the QI team’s self-efficacy to improve quality of care. Guided by the TFA, the QI teams’ acceptability was represented by the respective seven components of the multifaceted acceptability construct.Conclusions: Program acceptability varied by time, by champion role on QI team, by team self-efficacy, and by perceived effectiveness to improve quality of care aligned with the TFA. A complex quality improvement program that fostered flexibility in local adaptation and supported users with access to data, resources, and implementation strategies was deemed acceptable and appropriate by front-line clinicians implementing practice changes in a large, national healthcare organization.Trial Registration: clinicaltrials.gov: NCT02769338
Use of Probiotics to Reduce Infections and Death and Prevent Colonization with Extended-spectrum Beta-lactamase (ESBL) Producing Bacteria among Newborn Infants in Tanzania (ProRIDE Trial): Study Protocol for a Randomized Controlled Clinical Trial
Authors: Kuwelker Kanika , Langeland Nina , Löhr Iren , Gidion Joshua , Manyahi Joel , Moyo Sabrina , Blomberg Bjørn , Klingenberg Claus
Published: December 2020

Background: Extended-spectrum beta-lactamase producing Enterobacteriaceae (ESBL-E) has emerged as an urgent global health threat, and is by World Health Organization ranked as priority 1 among pathogens in need of new treatment. Studies have shown high mortality in Tanzanian children with ESBL-E infections. Gut colonization of ESBL-E, which is a potential risk factor of ESBL-E infections, is reported to be very high among children in Tanzania. Probiotics may potentially reduce gut colonization of multidrug-resistant bacteria. However, there is limited data on whether probiotics may reduce ESBL-E carriage in infants. The ProRIDE Trial aims to evaluate whether the use of probiotics can reduce morbidity and mortality among infants in Haydom, Tanzania, and whether this effect is mediated through prevention of ESBL-E carriage. Methods/Design: This large randomized double-blinded placebo-controlled trial aims to recruit 2000 newborn infants at Haydom Lutheran Hospital and the surrounding area in the period of November 2020 to November 2021. Participants will be enrolled from day 0-3 after birth, and randomized to receive probiotics or placebo for four weeks. Participants will be followed up for six months, during which three visits will be made to collect clinical and demographic information, as well as rectal swabs and fecal samples which will be subjected to laboratory analysis. The primary composite outcome is the prevalence of death and/or hospitalization at six months of age. Discussion: As the use of probiotics may give a more favorable gut composition, and thereby improve health and reduce morbidity and mortality, the results may have implications for future therapy guidelines in Africa and internationally. Trial Registration: www.clinicaltrials.gov , Trial identifier NCT04172012, Registered 21 November 2019
Tocilizumab improves survival in severe COVID-19 pneumonia with persistent hypoxia: A retrospective cohort study with follow-up from Mumbai, India
Authors: Gokhale Yojana , Mehta Rakshita , Kulkarni Uday , Karnik Nitin , Gokhale Sushant , Sundar Uma , Chavan Swati , Kor Akshay , Thakur Sonal , Triwedi Tripti , Kumar Naveen , Baveja Sujata , Wadal Aniket , Kolte Shaonak , Deolankar Aukshan , Pednekar Sangeeta , Kalekar Lalana , Padiyar Rupal , Londhe Charulata , Darole Pramod , Pol Sujata , Gokhe Seema Bansode , Padwal Namita , Pandey Dharmendra , Yadav Dhirendra , Joshi Anagha , Badgujar Harshal , Trivedi Mayuri , Shah Priyanshu , Bhavsar Prerna
Published: December 2020

Background: Cytokine storm triggered by Severe Corona Virus Disease 2019 (COVID-19) is associated with high mortality. With high ‘Interlukin -6’ (IL-6) levels reported in COVID-19 related deaths in China1, IL-6 is considered to be the key player in COVID-19 cytokine storm. Tocilizumab, a monoclonal antibody against IL-6 receptor, is used on compassionate grounds for treatment of COVID-19 cytokine storm. The aim of this study was to assess effect of tocilizumab on mortality due to COVID-19 cytokine storm.Method: This retrospective, observational study included patients of severe COVID-19 pneumonia with persistent hypoxia (defined as saturation 94% or less on supplemental Oxygen of 15 L per minute through non-rebreathing mask or PaO2/FiO2 ratio of less than 200) who were admitted to a tertiary care center in Mumbai, India, between 31st March to 5th July 2020. In addition to standard care, single Inj. Tocilizumab 400mg was given intravenously to 151 consecutive COVID-19 patients with persistent hypoxia, from 13th May to 5th July 2020. These 151 patients were retrospectively analysed and compared with historic controls, i.e consecutive COVID-19 patients with persistent hypoxia, defined as stated above (N=118, from our first COVID-19 admission on 31st March to 12th May 2020 i.e, till tocilizumab was available in hospital). Univariate and multivariate Cox regression analysis was performed for identifying predictors of survival. Statistical analysis was performed using IBM SPSS version 26. Results: On multivariate Cox regression analysis, independent predictors of survival were use of tocilizumab (HR 0.621, 95% CI 0.427-0.903, P 0.013) and higher oxygen saturation.Conclusion: Tocilizumab improved survival in severe COVID-19 pneumonia with persistent hypoxia
The concept of controlling the unmanned vehicles in open pit mining
Authors:   T. F. Gorbachev Kuzbass State Technical University, Chicherin Ivan , Fedosenkov Boris ,   T. F. Gorbachev Kuzbass State Technical University, Syrkin Ilia ,   T. F. Gorbachev Kuzbass State Technical University, Sadovets Vladimir ,   T. F. Gorbachev Kuzbass State Technical University, Dubinkin Dmitrii ,   T. F. Gorbachev Kuzbass State Technical University
Published: December 2020

Introduction. The article presents the results of studies related to the description of the synthesis and further analysis of the dynamic behavior of unmanned vehicles (UMV) operating in coal-mining pits and other mining quarries. The urgency of the discussed study is dictated by the need to create safe and effective conditions for stripping / mining and transportation operations. This is ensured, among other things, by the operation of unmanned heavy-duty dump cars. Research aim is to develop the concept for the formation of route parameters and models of the movement dynamics of vehicles along technological routes. Methodology. The paper describes the technology for generating and processing the signals in control subsystems as parts of both the computer-aided dispatching system and the on-board autonomous ISSN 0536-1028 «Известия вузов. Горный журнал», № 8, 2020 119 control subsystem of the UMV. The methods used in the research include the study of the forms and characteristics of current trajectories (CT) in relation to a nominal axial trajectory (NAT). In this case, a current trajectory of the UMV is considered within the framework of the so-called S-frames, which are generated in the form of geolocations on a working route of the UMV from the mining face to the place of unloading and vice versa. As a variable characterizing the behavior of the UMV on a current trajectory, a 1D-signal with a time-dependent frequency is adopted, the nature of the change of which is determined by the dynamic shape of a CT with regard to the NAT. Results. Such chirp-signals, together with the wavelet transform apparatus introduced into consideration, allow in a semantically transparent and information-rich video graphic form to represent and subject to further processing the signals characterizing a certain UMV current behavior on the route. The obtained parameters of such secondary wavelet representations of the UMV current dynamics (wavelet maps) are further planned to be used in the subsystem for dynamic modal controlling the UMV movement in the opencast mine. Conclusions. The results of the research allow us to form current routes of UMVs movement according to the models based on the analytical tools accompanying the dynamics of the UMV, proposed in the work.
The 100th Anniversary of the Department of Mining Engineering of UrSMU
Authors:   Ural State Mining University, Valiev Niiaz , Propp Vladimir ,   Ural State Mining University, Vandyshev Aleksandr ,   Ural State Mining University
Published: December 2020

The article is dedicated to the history of the Department of Mining Engineering establishment and development. The Department of Mining Arts used to be its original name. The department has been reformed several times over its centennial history. In 1931 the country was in urgent need in engineers with narrow specializations and the department was divided into 6 departments: sheet deposits development, ore mining, mine construction, mine aeration and work safety, mine transport, and industrial management. Each of the departments still exists making its contribution to high-skilled mining engineers training. The departments of sheet deposits development and ore mining were an exception, as soon as they amalgamated 78 years later to establish the Department of Mining Engineering in 2009. Over the entire period of its existence, the departments of mining art-mining engineering have trained more than 10 thousand mining engineers, including 52 thousand specialists for foreign countries. The graduates have been working successfully in all regions of the Soviet Union and still work for mining enterprises in Russia and abroad. There are 2 academicians, 18 Doctors of Science, more than 60 PhDs, 3 Lenin and State Prize laureates, 6 Heroes of Socialist Labour, 2 Deputy Ministers of the Government of the Russian Federation, local Government Chairmen, and Governors of the regions of the Russian Federation among the graduates of the department.
Specifying the approaches to geoinformation monitoring to assess the development dynamics of mining enterprises as natural-technological systems
Authors:   Institute of Mining UB RAS, Kornilkov Sergei , Antoninova Natalia ,   Institute of Mining UB RAS, Panzhin Andrei ,   Institute of Mining UB RAS, Shubina Liubov ,   Institute of Mining UB RAS, Isakov Sergei ,   Ural State Mining University
Published: December 2020

Introduction. The article considers problems related to the need in a system of indicators assessing mining technological conditions variation based on mining dynamics monitoring as well as its harmful environmental impact, which is constant over an indefinite period of time. Besides, the introduction of a block of biogeochemical indicators into the general indicative system in order to develop effective methods of environmental rehabilitation is associated with the study of self-healing processes, which will allow managing these processes, thereby accelerating the formation of stable and well-functioning ecosystems. Research aim. Base on the research, the article aims to determine approaches to geoinformation monitoring to assess the dynamics of mining enterprises formation as integrated natural-technological systems in order to choose a strategy for the environmentally safe development of natural deposits and technogenic mineral formations. Methodology. An algorithm for assessing the dynamics of mining enterprises formation as naturaltechnological systems is considered as well as the main directions and tasks of geoinformation monitoring as a tool for controlling technical risks and compensating for environmental risks during the development of solid mineral deposits. Results. The article considers methodological aspects of systematic assessment of natural deposits and man-made formations development projects implementation based on geoinformation monitoring data. Besides, the dynamics of mining enterprises formation as natural-technological systems is proposed to be assessed based on the ideology of modeling transient processes where the object changes its parameters from some initial (initial) to prescribed (final) by the approved design documentation. The transition process at least involves: a transformed natural system, a technological system that changes or affects the natural one, and a socio-economic system being a complex where the organizational, financial and economic activities of the enterprise are implemented in management.
Developing the technology of feldspar raw materials pre-flotation conditioning at the Kedrovoe deposit
Authors:   Uralmekhanobr OJSC, Gazaleeva Galina , Buzunova Tatiana ,   Uralmekhanobr OJSC, Shigaeva Varvara ,   Uralmekhanobr OJSC
Published: December 2020

Introduction. When developing the technology of fieldspar raw material processing, it is essential to select efficient modes of grinding and desliming. Research aim is to develop the technology of feldspar raw materials pre-flotation conditioning at the Kedrovoe deposit as applied to the technology of JSC Malyshevskoye rudoupravlenie. Methodology. Feldspar grinding kinetics in a ball mill was determined, and useful minerals disclosure degree was determined using AXIO Imager A1m optical microscope. The optimal size of sludge in ISSN 0536-1028 «Известия вузов. Горный журнал», № 8, 2020 61 hydrocycloning has also been identified. The object of research was a representative sample of pegmatites from the Kedrovoe deposit. Results. The research results showed that the optimal grinding time is 30 minutes, the content of the +0.16 mm size class is no more than 20–22%, and the optimal class for disliming with minimal losses of feldspar is minus 40 microns. The best results for product classification were obtained at a pressure at the inlet of the hydrocyclone of 1.2 bar, a sand packing diameter of 7 mm. The solids content in the feed was 24.15%, the content of particles with a size of minus 40 microns in the drain was 96.19%. Conclusions. Investigation of feldspar raw materials grinding and desliming at the Kedrovoe deposit made it possible to obtain dependencies for the effective control of the sludge content of minus 40 microns in the hydrocyclone discharge by changing the solids content in the feed and to identify effective grinding modes.
In-store promotion and customer value on private label product purchase intention
Authors: Maharani Nina , Helmi Arief , Mulyana Asep , Hasan Meydia
Published: December 2020

This study aims to determine the influence of in-store promotion in the form of price discount and price package on customer value and purchase intention. The research sample was 120 consumers purchasing the private label products in modern stores using a purposive sampling technique. The data were then analyzed using SEM PLS. The result revealed that all hypotheses were accepted and each variable studied showed a strong and significant influence on each other, especially in terms of its influence on the purchase intention. In-store promotion is a more influencing variable of purchase intention in private label products than customer value. The result also pointed out the three most dominant items forming in-store promotion, customer value, and purchase intention. Those items are the frequency of discount program, the products’ quality, and the reference group that helps the company promoting private label products, usually friends’ recommendation. These findings are expected to be used by decision-makers in retail businesses to formulate in-store promotional activities and create customer value following the target market to increase consumers’ willingness to buy private label products.
Acknowledgment The authors would like to express their gratitude to the Doctoral Dissertation Research Grant Program of the Ministry of Research, Technology, and Higher Education for funding this research. The authors highly appreciate the assistance, suggestions, and inputs from both editors and reviewers of this article.
An exhaustive research and analysis on seismic performance of prefabricated concrete shear wall structure
Authors: Chen Shuzhen , Poongodi M.
Published: December 2020

In order to accelerate the process of building industrialization, improve the overall stability and construction quality of the building. In this paper, a bolted connection method is designed to study the seismic performance of the composite concrete shear wall specimens with horizontal split joints from the aspects of bearing capacity, ductility, energy dissipation, deformation capacity and failure mode. The test results show that the bolted concrete shear wall is feasible and the connectors can effectively connect the upper and lower precast shear walls to form a whole with certain lateral stiffness. The energy dissipation capacity of the specimens is similar to that of other prefabricated concrete shear wall structures with “self-reduction”. The displacement Angle is greater than 1/120 of the limit value of the displacement Angle between elastic-plastic layers under the action of large earthquakes, and the specimen has good deformation capacity. The energy dissipation capacity of the structure from dynamics perspective reveals that smaller capacity of the specimen by providing energy dissipation factor E= 0.24 and equivalent viscous damping coefficient of 0.038.
Federalism in Russia: Current State and Emerging Trends
Authors: Salikov M.
Published: December 2020

The article considers the phenomenon of federal relations in modern Russia from a theoretical and normative point of view. Studying related categories, such as federalism, federation and federal system, the author comes to the conclusion that it is federal relations, which by their nature are purely legal relations, are the core of any federal system. It is the analysis of the dynamics of development of these relations that shows the viability of a particular federal system. Using the concept of systems theory, the author reveals the structure of federal relations, which includes their subjects, objects and content. In turn, the content of federal relations can be revealed using the principles of both the horizontal and the vertical separation of powers. In this regard, not only normative regulation (the Constitution, federal and regional laws), but also judicial practice are of great importance: namely, decisions of the Constitutional Court of the Russian Federation, which handed down a significant number of decisions revealing the essence of federal relations in specific cases and resolving existing problems. The development of the federal system, and, consequently, the actual federal relations can be traced in examples of an institutional and regulatory nature. Vivid examples of this development are structural changes in the federal system associated with the formation of a new constituent entity of the federation and the adoption of a new constituent entity in the federation. Such examples have occurred in modern Russia, although in the case of the adoption of new entities in the current regulatory framework, certain problems are found that should be eliminated by making appropriate amendments to the law governing the procedure for such adoption. The COVID-19 pandemic, unfortunately, has affected virtually every nation in the world. The relationship between the federal center and the constituent entities of the federation in such an extraordinary situation has been affected too and has undergone certain changes. Their analysis cannot but lead to a correction of the normative regulation of federal relations in the event of similar situations in the future. Amendments to the Constitution of the Russian Federation have affected a large layer of public relations. Federal relations are no exception, since the “Federated Structure” section of the Constitution includes a number of rather interesting changes.
People-Centered Approach and Youth Participation in BRICS: A Case of BRICS School
Authors: Gladun E. , Van der Merwe Reon C.A.
Published: December 2020

International Research and Educational Program “BRICS School” took place in Moscow on 5–10 October 2020.
Türkiye Türkçesinde 1930’lu Yıllardan Sonra Türetilen veya Canlandırılan Yeni Sözcüklerin Ağız Metinlerine Etkisinin Bir Örneklem Üzerinden Değerlendirilmesi
Authors: Çelik Anıl
Published: December 2020

Gelişen teknoloji ve kitle iletişim araçlarının Türkiye Türkçesi ağızlarının konuşulduğu yörelerin hemen her köşesine ulaşması sonucu ortaya çıkan etkileşimin bu ağızlara yoğun bir biçimde yansımaya başladığından Türkiye diyalektolojisi ile ilgili birçok kaynakta bahsedilmektedir. Bununla birlikte, ağız derlemelerinin kaynak kişilerinde bulunması gereken özellikler sıralanırken; öğrenim durumu, yöreden ayrılmamış olma, yaş, yörenin ağız özelliklerini taşıma, cinsiyet, meslek, büyük yerleşim merkezleriyle iletişim durumu gibi nitelikler ön plana çıkarılır. Zira bu niteliklerin bahsi geçen etkileşimin ağza ne denli yansıyacağına önemli etkilerde bulunduğu düşünülmektedir. Bu noktada söz konusu düşünceleri bilimsel bir yöntemle sınamak adına Türkiye Türkçesinde 1930’lu yıllardan sonra türetilen veya canlandırılan yeni sözcüklerin ağız metinlerine etkisinin ölçülmeye çalışılması birtakım yönlendirici veriler sağlayabilir. Çünkü yeni türetilen sözcüklerin halk diline geçmesi konusunda yazı dili, kitle iletişim araçları ve teknoloji son derece etkilidir. Eğer bu yeni sözcüklerin ağız metinlerinin söz varlığındaki yeri ve sıklığı tespit edilirse yazı dilinin ve teknolojinin ağızlara yapmış olduğu etkiye dair birtakım çıkarımlarda bulunmak mümkün olacaktır. Bu düşünceden hareketle bu çalışmada Anadolu ve Rumeli ağızlarından temsilî olarak seçilen dört örnek ağız çalışmasının söz varlığı yeni sözcükler üzerinden değerlendirilmiştir. Batı Grubu Ağızlarından Yalova İli Yerli Ağzı, Doğu Grubu Ağızlarından Yusufeli Ağzı, Kuzeydoğu Grubu Ağızlarından Arhavi İlçesi Derecik Köyü Ağzı ve Rumeli Ağızlarından Lüleburgaz Ağızları üzerine yapılmış çeşitli lisansüstü tez çalışmalarından yola çıkılarak bu dört örnek ağız bölgesi söz konusu bağlamda karşılaştırmaya tabi tutulmuştur.
Hüzünlü ve Neşeli Müziklerin Kısa Süreli Bellek Üzerine Etkisi
Authors: Toptaş Hazal , Erdal Barış , Kındap Tepe Yeliz , Çiğdem Burhanettin , Topaktas A. Suat
Published: December 2020

Araştırmada neşeli ve hüzünlü müzik dinlemenin Kalp Hızı Değişkenliği (KHD) ve kısa süreli bellek performansı üzerindeki etkisi incelenmiştir. Bu amaçla araştırmaya müzik eğitimi alan 33’ü erkek (%50.8) ve 32’si (%49.2) kadın toplam 65 üniversite öğrencisi tesadüfi yolla seçilmiştir. Katılımcıların yaş ortalaması 21.68’dir (ranj = 18-30, S = 2.48). Araştırmada bellek performanslarını belirlemek için Sayı Dizisi Öğrenme Testi ters ve düz kodlama yoluyla; otonom sinir sistemi aktivasyonu Kalp Hızı Değişkenliği (KHD) ölçümüyle değerlendirilmiştir. Yapılan analizler sonucunda neşeli müzik dinleme sırasındaki kalp hızının ve LF/HF’nin hüzünlü müzik dinleme sırasındaki kalp hızı ve LF/HF değerlerinden yüksek olduğu bulunmuştur. Ayrıca hüzünlü müzik dinleme sırasındaki HF’nin neşeli müzik dinleme sırasındaki HF’den yüksek olduğu görülmüştür. Müzik dinleme öncesindeki KHD değerlerinin ise birbirinden farklılaşmadığı belirlenmiştir. Hüzünlü müzik dinleme sırasında yüksek frekans (HF) değerlerinin artması parasempatik aktivasyonun bir göstergesi olarak yorumlanmıştır. Neşeli müzik dinledikten sonraki KHD değerlerinin cinsiyete göre farklılaşmadığı belirlenmiştir. Ancak hüzünlü müzik dinledikten sonraki KHD değerlerinin cinsiyete göre farklılaştığı yani erkeklerin hüzünlü müzik dinleme sonrası LF ve LF/HF skorlarının kadınlardan yüksek olduğu görülmüştür. Bu bulgu erkeklerin kadınlara göre sempatik aktivasyon derecesinin daha yüksek olduğunu, dolayısıyla hüzünlü müziklerden daha fazla etkilendiğini göstermektedir. Katılımcıların sayı dizisini düz kodlama skorlarına göre müzik öncesi, hüzünlü ve neşeli müzik dinledikten sonrasındaki değerlerin birbirinden farklılaşmadığı görülmüştür. Ancak sayı dizisini müzik öncesi tersten kodlama ile hüzünlü ve neşeli müzik dinledikten sonra tersten kodlama skorları arasında farklılaşma bulunduğu tespit edilmiştir. Müzik dinleme öncesindeki sayı dizisini ters kodlama skorlarının hüzünlü müzik ve neşeli müzik dinledikten sonraki ters kodlama skorlarından düşük olduğu belirlenmiştir. Tüm bu sonuçlar neşeli ve hüzünlü müziklerin bellek performansı üzerinde pozitif etkiler uyandırdığına işaret etmektedir.
Natural Plus Synthetic Hydrotropic Solubilization using Response Surface
Methodology to Optimize the Solid Dispersion of Hydrochlorothiazide
Authors: Saharawat Arun , Deepali  , Nainwal Nidhi
Published: December 2020

Background:

Solubility/dissolution is said to be the key factor that influences the oral bioavailability of drug and
is also the rate limiting step in formulation development.

Objective:

Hydrochlorothiazide (HCZ) is a BCS Class IV drug with low solubility and low permeability. The present work
aimed to increase the solubility of hydrochlorothiazide using blends of natural and synthetic hydrotropes.

Methods:

Two hydrotropes one from natural (piperazine) and other from synthetic origin (sodium benzoate) were selected
for the formulation of solid dispersion (SD) of HCZ. Preliminary trial batches were prepared by considering the safe dose of
both the selected hydrotropes i.e. sodium benzoate (SB) and piperazine (PP). A 32 full factorial design was opted for
preparing the optimized solid dispersion of hydrochlorothiazide.

Results:

The quadratic models were found to be best fitted for the studied responses, which were percent solubility and invitro drug release. The results showed increased solubility and in-vitro drug release of HCZ solid dispersions as a function
of increasing levels of both hydrotropes.

Conclusion:

In this work, it was concluded that the use of natural hydrotropes along with synthetic hydrotropes gave an
effective and safe approach for the solubility enhancement of the HCZ.
Study of the Parameters Affecting the Loading of Fluorescein on Coated Gold Nanoparticles: Promising Nanostructure for Cancer Diagnosis
Authors: Hendi Nazanin , Shakeri-Zadeh Ali , Attaran Neda , Alamzadeh Zahra , Asefnejad Azadeh
Published: December 2020

Background:

Recent advances in nanotechnology have led to the use of nanomaterials in the diagnosis
of cancer by imaging techniques.

Objective:

This study aimed to synthesize fluorescein-conjugated gold nanoparticles and study the parameters
affecting the loading of fluorescein on synthesized coated gold nanoparticles with the ability to be used in medical
diagnostic methods.

Methods:

The synthesized gold nanoparticles were functionalized with polyethylene glycol. Then, these particles
were conjugated with fluorescein under different conditions. To investigate the optical and structural features
as well as the factors affecting the loading, the nanoparticles were evaluated by ultraviolet-visible, fluorescence
and FT-IR spectrophotometer, fluorescence spectrophotometer, transmission electron microscopy, dynamic
light scattering, and zeta potential measuring device. Also, the use of these particles in cancer diagnosis
on the skin melanoma cell (B16F10) was examined using a fluorescence microscope.

Results:

PEG-coated spherical gold nanoparticles were synthesized as a carrier for the fluorescein dye detector.
The coating agent concentration, incubation time, temperature, and pH of the medium affected the loading efficiency
of fluorescein on the nanoparticles. Also, optimal conditions for use in the diagnostic applications were
investigated. Ten micromolar of the sample were selected for cell imaging studies. The fluorescence signal of
B16F10 cells containing nanoparticles was relatively strong, indicating the amount of nanoparticles uptaken by
the cells.

Conclusion:

The results showed that by designing fluorescent gold nanoparticles with fluorescein as fluorescent
detectors and considering their diagnostic importance, an efficient way to diagnose incurable diseases can
be found.
Pharmacological Strategies for COVID-19 - A Review of the Most Promising Repurposed Antiviral Drugs
Authors: Chopra Deepti , Boparai Jaspreet K , Bhandari Bharti , Srivastava Anurag , Gupta Rakesh
Published: December 2020

:

A novel coronavirus, SARS- CoV-2 (2019-nCoV), emerged in December 2019 as an immediate
global challenge. Comprehensive efforts at the present time are focused simultaneously on
containing the spread of this virus and extenuating the ill effects. There is an immediate need for
drugs that can help before a vaccine can be developed. Researchers are endeavoring to find antiviral
therapies specific to the virus. As the condition is an emerging, rapidly evolving situation and
development of new drugs is a long process, and is unfeasible to face the immediate global challenge.
Strategy to reposition the previously used drugs can prove to be effective to combat this difficult
to treat pandemic. Several drugs such as Hydroxychloroquine, Umifenovir, Remdesivir, Lopinavir/
Ritonavir, interferon, Darunavir, Favipiravir, Nitazoxanide, etc. are currently undergoing clinical
studies to test the safety and efficacy of the drug against this pandemic. The present review
gives a snapshot look at the current clinical experience with repurposed antiviral drugs.
Implications of the COVID-19 Pandemic for the Development and Update of Clinical Practice Guidelines: Viewpoint
Authors: Steeb Theresa , Follmann Markus , Hagen Ralf Matthias , Berking Carola , Heppt Markus Vincent
Published: December 2020

Following the rapid spread of a new type of coronavirus (SARS-CoV-2), nearly all countries have introduced temporary restrictions affecting daily life, with “social distancing” as a key intervention for slowing the spread of the virus. Despite the pandemic, the development or actualization of medical guidelines, especially in the rapidly changing field of oncology, needs to be continued to provide up-to-date evidence- and consensus-based recommendations for shared decision making and maintaining the treatment quality for patients. In this viewpoint, we describe the potential strengths and limitations of online conferences for medical guideline development. This viewpoint will assist guideline developers in evaluating whether online conferences are an appropriate tool for their guideline conference and audience.
Usability of a Co-designed eHealth Prototype for Caregivers: Combination Study of Three Frameworks (Preprint)
Authors: Tremblay Melanie , Latulippe Karine , Guay Manon , Provencher Véronique , Giguère Anick , Poulin Valérie , Dubé Véronique , Giroux Dominique
Published: December 2020

BACKGROUND

Co-design (or the participation of users) has shown great potential in the eHealth domain, demonstrating positive results. Nevertheless, the co-design approach cannot guarantee the usability of the system designed, and usability assessment is a complex analysis to perform, as evaluation criteria will differ depending on the usability framework (or set of criteria) used. ISO (International Organization for Standardization) on usability (ISO 9241-210), Nielsen heuristic, and Garrett element of user experience inform different yet complementary aspects of usability.

OBJECTIVE

This study aims to assess the usability and user experience of a co-design prototype by combining 3 complementary frameworks.

METHODS

To help caregivers provide care for functionally impaired older people, an eHealth tool was co-designed with caregivers, health and social service professionals, and community workers assisting caregivers. The prototype was a website that aims to support the help-seeking process for caregivers (finding resources) and allow service providers to advertise their services (offering resources). We chose an exploratory study method to assess usability in terms of each objective. The first step was to assess users’ first impressions of the website. The second was a task scenario with a think-aloud protocol. The final step was a semistructured interview. All steps were performed individually (with a moderator) in a single session. The data were analyzed using 3 frameworks.

RESULTS

A total of 10 participants were recruited, 5 for each objective of the website. We were able to identify several usability problems, most of which were located in the information design and interface design dimensions (Garrett framework). Problems in both dimensions were mainly coded as effectiveness and efficiency (ISO framework) and error prevention and match between the system and the real world (Nielsen heuristic).

CONCLUSIONS

Our study provided a novel contribution about usability analysis by combining the 3 different models to classify the problems found. This combination provided a holistic understanding of the usability improvements needed. It can also be used to analyze other eHealth products.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/11634