bluuebunny/crossref_metadata_2025 huggingface dataset:
Fístulas enterocutâneas e enteroatmosféricas – terapêuticas e a enfermagem: revisão de literatura
Authors: Costa Gabriela de França , Oliveira Hellen Carolyne Andrade de , Wilk Mirce Meire Gonçalves de Sousa
Published: February 2023

O presente estudo teve como objetivo analisar, por uma revisão de literatura, a condução terapêutica de enfermagem e dos outros profissionais de saúde às fístulas enterocutâneas e enteroatmosféricas, em especial as pós-anastomóticas. Para isso, realizou-se uma revisão de literatura, com buscas conduzidas no período de agosto a novembro de 2022, nas bases de dados eletrônicas BVS, PubMed e Scielo, nos idiomas: português, inglês e espanhol. Essa pesquisa baseou-se nos descritores encontrados no DeCS e MeSH, e considerando critérios de inclusão e exclusão determinados pelas autoras. Ao total foram encontrados 2015 artigos, sendo que: 727 da BVS, 1288 da PubMed e sem resultados encontrados na Scielo. Desses, 1275 foram excluídos por estarem duplicados e os outros 740 tiveram título e resumo lidos. No final da análise, 21 artigos foram selecionados, pois atendiam à pesquisa. Foi possível concluir que o cuidado a pessoas com fístulas enterocutâneas e enteroatmosféricas no âmbito clínico, tem uma abordagem multidisciplinar. É certo, portanto, que a enfermagem desempenha um importante papel nesse manejo e apesar da escassez de estudos que abordem especificamente sobre o tema, foi possível identificar os principais cuidados de enfermagem que devem ser considerados nesse manejo.
Análise temporal da realização da revascularização miocárdica em pacientes hospitalizados pelo Sistema Único de Saúde brasileiro nos últimos 10 anos
Authors: Frazão Luiz Felipe Neves , Batista Matheus Neres , Souza Victor Vinicius da Cruz , Moura Najara Micaela Peixoto de , Basílio Pedro de Oliveira Batista , Oliveira Júnior Jeferson Lopes de , Lopes Pedro Henrique de Souza , Costa Bruno Henrique Barbosa Sabino da
Published: February 2023

O objetivo dessa pesquisa é analisar a comparação, criando uma análise temporal, das internações, valor médio por internação e taxas de mortalidades, entre todas as regiões brasileiras, no que tange a cirurgia de revascularização do miocárdio (CRVM). Trata-se de um estudo ecológico, com abordagem quantitativa e análise de sequências temporais. Foi pesquisada a população brasileira que tenha sido submetida a CRVM no intervalo de 2012 – 2022 em hospitais do Brasil, cujos procedimentos tenham sido financiados pelo Sistema Único de Saúde (SUS). Para análise temporal das sequências das taxas, foram definidas as variáveis: Internações; Região (Norte, Nordeste, Centro-Oeste, Sul e Sudeste); Taxa de mortalidade; Valor Médio AIH; Valor Total. Segundo o banco de dados do DATASUS, durante o período de 2012 a 2022, em todo território brasileiro, das 124.947.182 internações confirmadas pelo SUS, foram identificadas 228.765 CRVM (0,18%) realizadas em todo Brasil. Evidenciando predomínio de internação na região Sul, com valor médio de R$ 13.200,42 no Brasil e uma taxa de mortalidade em crescimento.
Potencial terapêutico da cetamina em transtornos depressivos
Authors: Mendes Lucas Ferrari da Silva , Bezerra Camila de Sá , Piauilino Bárbara Cândida Nogueira , Sousa Lourivan Leal de , Leal Anne Kaline Marques Portela , Moura Paulo Ricardo de Sousa e Silva , Silva Lucas Solano Araújo da , Noronha Maria Yasmin de Carvalho , Menezes Antônio Gleysson Vieira Abreu
Published: February 2023

Introdução: Um terço dos indivíduos que convivem com transtorno depressivo maior não respondem ao tratamento à base de antidepressivos. A ideação suicida é um agravante frequentemente presente e que é possivelmente letal se não abordado. O difícil controle da ampla sintomatologia relacionada à depressão em determinados pacientes demonstra a necessidade de novas e eficientes estratégias terapêuticas. Verificou-se que a cetamina, apresenta resultados antidepressivos quando administrada em doses subanestésicas. Este trabalho tem como objetivo verificar o potencial antidepressivo da cetamina sobre o transtorno depressivo maior e transtorno depressivo resistente nas produções científicas publicadas entre 2017 a 2022. Metodologia: Trata-se de uma revisão integrativa da literatura. Após busca na base de dados Biblioteca Virtual em Saúde, foram encontradas 100 publicações, mas apenas12 artigos atendiam aos critérios de inclusão. Resultados e discussão: Indica-se como causa da rápida atenuação dos sintomas depressivos o bloqueio dos receptores NDMA promovido pela cetamina, que restabelece a dinâmica sináptica de algumas vias glutamatérgicas desajustadas nos transtornos depressivos, restaura a atividade neural de importantes circuitos relacionados ao stress, à resiliência e à regulação do humor, essencialmente modulando a função de controle cognitivo emocional. Além disso, atua regulando reações imunoinflamatórias disfuncionais envolvidas na fisiopatologia da depressão. Conclusão: A utilização da cetamina para tratamento de transtorno depressivo maior e transtorno depressivo resistente tem demonstrado resultados relevantes que a elencam como forte candidata para compor o arsenal adotado por guidelines internacionais.
Intervensi Permen Hard Candy Dengan Kandungan Teh Hitam Dan Sorbitol Untuk Penurunan Skor Plak Anak-Anak Usia Sekolah
Authors: Prihastari Lisa
Published: February 2023

Background: The use of black tea as an anti-plaque and anti-caries material is still very limited in Indonesia. Various studies have shown the benefits of black tea which can reduce plaque scores, increase fluoride levels and inhibit the growth of Streptococcus mutans bacteria. The innovation of black tea in the form of candy is expected to be liked by children and does not eliminate its benefits as an alternative to anti-cariogenic ingredients. Objective: To determine the difference in effectiveness between consuming black tea candy with sorbitol and placebo candy (sorbitol only) in reducing plaque accumulation. Methods: This study is a experimental using a Randomized Controlled Clinical Trials (RCT) design and a single blind method. The research subjects consisted of 42 students at SDN 019 Cempaka Putih and SDN 03 Pagi Pasar Minggu, aged 7-8 years. The sample was selected based on the inclusion criteria of the study. The examination was carried out to determine plaque scores using the Loe and Sillness index and pufa index scores which were measured in 3 measurement times, namely day 1, day 7 and day 23. Results: The average PUFA index of research subjects was 1,05. The results of this study showed that there was a significant decrease in plaque scores in each group before and after consuming sweets on the 1st day, 7th day and 23rd day measurement (p-value 0.05). In the black tea group, there was a greater reduction in plaque scores than the placebo group.. Conclusion: Consuming black tea candy compared to placebo candy containing sorbitol had the same effectiveness in reducing plaque scores.
Mind Mapping dan Daya Berpikir Ilmiah Terhadap Hasil Belajar Pada Mata Pelajaran Pendidikan Agama Islam pada Siswa di SMAN 20 Kab. Tangerang
Authors: Heriyanto Toto
Published: February 2023

Penelitian ini bertujuan untuk mengetahui bagaimana penggunaan mind mapping dan daya berpikir ilmiah dalam meningkatkan hasil belajar siswa pada mata pelajaran pendidikan agama Islam. Latar belakang penelitian ini bersumber pada kondisi dan situasi kegiatan belajar mengajar di sekolah yang masih menggunakan pendekatan konvensional. Penelitian ini dilakukan pada kelas XI SMAN 20 Kab. Tangerang.Metode yang digunakan dalam penelitian ini adalah metode penelitian eksperimen. Sedangkan untuk menganalisis dan menguji hipotesis menggunakan analisis varian (ANAVA) dua jalur. Teknik pengumpulan datanya menggunakan tes dan angket. Tes digunakan untuk mengukur hasil belajar PAI melalui penggunaan mind mapping. Hasil penelitian dengan analisis varian (ANAVA) dua jalur menunjukkan bahwa:Terdapat perbedaan hasil belajar PAI antara siswa yang belajar menggunakan mind mapping dan daya berpikir ilmiah dengan siswa yang belajar menggunakan pendekatan konvensional. Siswa yang belajar menggunakan mind mapping dan daya berpikir ilmiah mempunyai hasil belajar yang lebih tinggi dibandingkan dengan siswa yang belajar menggunakan pendekatan konvensional
ANGLIČTINA V AKADEMICKOM PROSTREDÍ (cvičebnica). ENGLISH FOR DOCTORAL STUDENTS
Authors:   Pavol Jozef Šafárik University in Košice, Kolaříková Zuzana , Petruňová Helena , Timková Renáta
Published: February 2023

The publication contributes to an active acquisition and development of language skills in the area of academic English. Individual lessons include tasks in which the user will find a lot of useful vocabulary in the form of collocations, phrases and sentences which can be applied in practice. The tasks are focused on the area of English pronunciation, grammar, word formation, vocabulary, improving communicative competence in written and verbal communication, improvement of professional skills of presentation, academic writing, etc. The publication provides space for complementing and creating own database of vocabulary (topic pages).
Desgaste profesional y job performance en colaboradores de entidades microfinancieras en la región Junín
Authors: Aguilar-Tinoco Jhordana A. , Bermudo-Soto Luz M. , Lazaro-Lino Keyla I. , Valdez-Barreto Evelyn , Ramírez-Arellano Miguel A.
Published: February 2023

Actualmente puede observarse altos niveles de desgaste profesional asociado a niveles bajos de desempeño y, por tanto, de productividad en diversos sectores empresariales. El objetivo formulado fue medir la relación existente entre desgaste profesional y job performance en entidades microfinancieras de la región Junín. La investigación estuvo enmarcada en los lineamientos del paradigma cuantitativo y en los criterios de un diseño no experimental-transversal, de tipo básico observacional y nivel relacional. La muestra lo conformaron 190 colaboradores de entidades microfinancieras de la región Junín. La técnica empleada fue la encuesta, se midió el desgaste profesional utilizando el inventario de agotamiento de Maslach y para medir job performance se utilizó la escala de desempeño laboral, los datos fueron analizados con el soporte del SPSS 25 para Windows. Los resultados muestran correlación negativa de -0,224 entre desgaste profesional y job performance con un p-valor de 0,027. Por tanto, se concluyó que existe correlación negativa significativa entre desgaste profesional y job performance en colaboradores de entidades microfinancieras de la región Junín.
PENDIDIKAN KARAKTER RELIGIUS BERBASIS BUDAYA SEKOLAH DI SD ISLAM PLUS AS-SYAFI'IYAH TANGGULANGIN
Authors: Maftukha Aniq , Kurniawan Machful Indra
Published: February 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan Pendidikan karakter religius berbasis budaya sekolah di SD Islam Plus As-Syafi’iyah Tanggulangin Sidoarjo. Metode penelitian ini menggunakan metode kualitatif deskriptif dengan teknik pengumpulan data yang dilakukan menggunakan wawancara, observasi, dan dokumentasi. Untuk analisis data yang dilakukan dengan menggunakan pengumpulan data (data collection), Reduksi Data (Data Reduction), Penyajian Data ( Data Display ), Penarikan Kesimpulan/Verifikasi (conclusions). Hasil penelitian menunjukkan bahwa Pendidikan karakter religius berbasis budaya sekolah di SD Islam Plus As-Syafi’iyah Tanggulangin diintegrasikan dalam tiga jenis Pendidikan yaitu Pendidikan Intrakurikuler, Kokurikuler, dan Ekstrakurikuler. Dalam Pendidikan intrakurikuler diterapkan dengan menambah materi ajar pembelajaran PAI (Fiqih, Aqidah dan Bahasa Arab), penyusunan RPP serta memberikan pesan-pesan moral dan nilai-nilai religius pada setiap akhir pembelajaran. Dalam Pendidikan kokurikuler mengunakan praga, praktik dan media sebagai penunjang pembelajaran. Dan pada Pendidikan ektrakurikuler seperti drum band, pramuka, computer, kaligrafi, Qira’ah dan seni sholawat Al-banjari. Terdapat Pembelajaran Al-Qur’an dengan menggunakan metode pembelajaran Qira’ati sebagai menunjang program  tahfidz Qur’an. Budaya sekolah yang dimiliki yaitu 5S, sholat berjama’ah, shobahul Qur’an, berdo’a sebelum dan sesudah belajar, budaya membaca surah-surah pendek dalam juz 30, budaya membaca do’a–do’a harian, budaya membaca dan menulis Al-Qur’an, budaya infaq pada hari jum’at, budaya peringatan hari besar islam, budaya wisata religi.
Autosomal Dominant Polycystic Kidney Disease: Review and Management Update
Authors: Martínez Víctor
Published: February 2023

Autosomal dominant polycystic kidney disease (ADPKD) is the most common inherited nephropathy. Initially, it is characterised by the growth of renal cysts. Later, progressive deterioration of renal function determines the prognosis of ADPKD, depending on the main factors of progression (genetic, renal volume, and hypertension). Ultrasonography is the diagnostic technique of choice in the screening for relatives of ADPKD patients. Due to the absence of specific treatment it is necessary, in many cases, to start with renal replacement therapy. ADPKD can also be associated with extrarenal manifestations, mainly polycystic liver disease and cerebral aneurysms, which contribute to increased morbidity and mortality of these patients.
Rituximab and Other New Anti-CD20 MAbs for Non-Hodgkin’s Lymphoma Treatment
Authors: Polito Letizia , Bortolotti Massimo , Maiello Stefania , Battelli Maria Giulia , Bolognesi Andrea
Published: February 2023

Non-Hodgkin’s lymphomas (NHLs) are a heterogeneous group of different haematological cancers with a wide range of aggressiveness. NHLs represent >80% of lymphomas and the majority of NHLs involve B cells. CD20 represents a good target for NHL immunotherapy because it is largely expressed on B cell NHL and not on B cell precursors and plasma cells. The anti-CD20 monoclonal antibody (mAb) rituximab (RTX) was the first antibody approved by the FDA for lymphoma therapy and has revolutionised B cell lymphoma treatment. Several clinical trials have demonstrated the high efficacy of RTX, resulting in a significant improvement in overall response rates and in NHL patient survival. However, RTX, both as a single agent and in combination with chemotherapy, induces several side-effects and resistance mechanisms. Remarkable efforts have been made to improve RTX efficacy, including conjugation to an active moiety (radionuclide, toxin, enzyme, or drug) and the development of new anti-CD20 mAbs. This review summarises the characteristics of RTX and other anti-CD20 mAbs for NHL treatment; the results of the main clinical trials are reported.
Development of matrix calculator learning media
Authors: Ariyanti Novia , Taurusta Cindy , Amir Mohammad Faisal
Published: February 2023

The purpose of this research is to design dan develop an android-based matrix calculator learning media. This type of research is research and development. The model used in research development is the ADDIE model which consists of five stages namely Analyze, Design, Development, Implementation, and Evaluation. The matrix calculator learning media developed has met the feasibility of valid, practical and effective media. The difference with other matrix calculator application is that in this application there is a solution to a three-variable system of linear equations using the Cramer method. Where is the Cramer method in its completion using matrix arithmetic operations.
Pengaruh Pemberian Traksi-Translasi dan Hold Relax Terhadap Perubahan ROM Shoulder Akibat Capsulitis Adhesive
Authors: Hikmah Nurul , Fatimah Fitriah Nurul , Sudaryanto Sudaryanto
Published: February 2023

Latar Belakang : Capsulitis Adhesive adalah gangguan yang terjadi di area bahu berupa peradangan pada kapsul sendi yang menyebabkan rasa kaku dan nyeri. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian trkasi-translasi dan hold relax terhadap perubahan ROM shoulder pada pasien Capslitis adhesive. Metode : Penelitian ini adalah  penelitian Pra Eksperimen dengan One group pre-test & post-test design. Populasi sampel adalah penderita Capsulitis Adhesive Poli Fisioterapi Rumah Sakit Umum Daerah Barru. Pengambilan data pasien dengan menggunakan goniometer pre-test dan post-test.  Selama masa penelitian jumlah sampel sebanyak 12 responden yang diambil menggunakan teknik total sampling yaitu seluruh penderita. Hasil : Hasil penelitian menunjukkan penderita yang mengalami Capsulitis Adhesive lebih banyak dialami kelompok usia  ≥ 45 tahun dan jenis kelamin sebagian besar perempuan.  ROM sebelum & sesudah pemberian intervensi menunjukkan ada perubahan yang signifikan dari nilai p=0,000 dengan tingkat kepercayaan 95%. Berdasarkan Uji Paired Sampel T Test dengan nilai p= 0,000 < (0,05) telah memperlihatkan bahwa terdapat pengaruh traksi-translasi dan hold relax terhadap perubahan ROM pada penderita Capsulitis Adhesive. Kesimpulan : Disimpilkan bahwa ROM sebelum & sesudah pemberian traksi-translasi & hold relax memperlihatkan ada perubahan  ROM setelah diberikan teknik traksi-translasi dan hold relax.
Hubungan Gaya Hidup Dengan Kejadian Stroke Di Rumah Sakit
Authors: Wijianto Wijianto , Yuda Wanda Kurnia
Published: February 2023

Stroke is a neurological disorder associated with vascular injury of the central nervous system. This disease is the second leading cause of death and the leading cause of disability worldwide. The prevalence of stroke in Indonesia increases with age. The highest stroke cases were aged 75 years and over (50.2%) and the lowest was 15-20 years (0.6%). Based on gender, male (11.0%) was more than female (10.9%). Stroke can be done by controlling lifestyle such as smoking, alcohol consumption, light physical activity, unhealthy eating patterns. The population in this study was to find stroke patients at Moewardi Hospital. Samples were outpatients at Anggrek 2 and inpatients at instalasi rehabilitasi medik totaling 30 patients. The method used is analytic observational with cross sectional design. Collecting data through direct interview techniques to the patient or the patient's guardian. The statistical test used to analyze the data in this study was the chi square test. The results of data analysis showed a relationship between diet (p=0.025 <0.05) and physical activity (p=0.010 <0.05) with the incidence of stroke at Dr Moerwardi Hospital, and there was no significant relationship between smoking (p=0.459 > 0.05) and alcohol (p = 0.309 > 0.05) with the incidence of stroke in Dr Moewardi Hospital.
Berjalan Tanpa Alas Kaki Lebih Mengaktivasi Otot Tungkai Bawah Dibanding Berjalan Menggunakan Sepatu
Authors: Haryatno Pajar , Romadhon Aditya Johan
Published: February 2023

Aktivitas berjalan merupakan kebutuhan dasar manusia dalam melakukan transfer dan ambulasi, penggunaan alas kaki seperti sepatu dapat membatasi informasi sensoris pada reseptor sensoris tungkai bawah. Penelitian ini dilakukan guna mengetahui perbandingan aktivasi otot tungkai bawah antara berjalan tanpa alas kaki dan penggunaan sepatu. Subjek yang digunakan pada penelitian ini adalah 100 mahasiswa jurusan Fisioterapi Politeknik Kesehatan Surakarta yang memenuhi kriteria inklusi dan eksklusi, yang telah ditetapkan. Subjek pada penelitian ini di bagi menjadi 2 kelompok, Kelompok 1 melakukan aktivitas berjalan tanpa alas kaki dan Kelompok 2 berjalan dengan alas sepatu, pada kedua kelompok tersebut diberikan surface electromyograph berupa myofeedback pada otot tibialis anterior dan gastrocnemius selama aktivitas berjalan, perekaman aktivasi otot tibialis anterior dan gastrocnemius dilakukan selama subjek berjalan lurus kedepan sejauh 5 meter. Rerata nilai aktivasi otot tibialis anterior lebih besar saat subjek melakukan aktivitas berjalan menggunakan sepatu dibanding tanpa alas kaki, sedangkan aktivasi otot gastrocnemius lebih besar pada kelompok tanpa alas kaki dibanding kelompok menggunakan sepatu, dengan nilai kebermaknaan p< 0.05. Berjalan tanpa alas kaki mampu mengaktifkan otot-otot kecil pada kaki dan otot-otot besar pada tungkai dibanding penggunaan sepatu.
The Hubungan Tingkat Kebugaran Kardiorespirasi Dengan Kualitas Hidup Pada Penyintas Coronavirus Disease 2019 Di Kota Makassar
Authors: Nur'amalia Riskah , Awaliah Tariza Resky , Husna Puja Asmaul
Published: February 2023

Pendahuluan: Penyintas Covid-19 sering mengeluhkan beberapa gejala pasca terinfeksi seperti kelelahan, batuk, sesak napas, demam, dermatitis, sakit kepala dan lain sebagainya. Gejala-gejala tersebut menetap hingga berbulan-bulan, akibatnya terjadi limitasi fungsional berupa penurunan toleransi aktivitas fisik yang dirasakan penyintas Covid-19 kemudian berdampak terhadap perubahan kebugaran Kardiorespirasi serta berdampak pada kualitas hidup. Tujuan: penelitian ini bertujuan untuk mengetahui hubungan tingkat kebugaran Kardiorespirasidan kualitas hidup pada penyintas Covid-19 di kota Makassar. Metode: penelitian ini menggunakan desain cross sectional. Populasi penelitian ini adalah penyintas Covid-19 di Kota Makassar. Pengambilan sampel menggunakan teknik purposive sampling dengan jumlah sampel 385 orang (n=385). Pengumpulan data dilakukan dengan pengambilan data primer melalui pengukuran tingkat kebugaran Kardiorespirasi menggunakan Six Minute Walk Test (6MWT) dan kualitas hidup dengan pengisian kuisioner SF-36. Hasil: dimana tidak terdapat hubungan yang signifikan antara tingkat kebugaran Kardiorespirasidengan kualitas hidup pada penyintas Covid-19 di kota Makassar
PRACTICAL FEATURES OF THE QUALIFICATION OF ACTS AIMED AT NON-EXECUTION OF A COURT VERDICT, COURT DECISION OR OTHER JUDICIAL ACT
Authors:   Rostov State Economic University (RINH), Rostov-on-Don, Russia, BARKHO VLADIMIR
Published: February 2023

This article is devoted to the consideration of the practical features of the qualification of acts for the commission of which criminal liability occurs if it turns out that they are aimed at non-execution of certain judicial acts. The relevance of the research topic is determined by the fact that the range of human rights is extremely wide, while the state has undertaken to protect them from illegal and unjustified encroachments. In this regard, everyone has the right to apply to the court for the protection of their rights and interests (part 1 of Article 46 of the Constitution of the Russian Federation). Currently, the activities of domestic courts are focused primarily on the correct, timely and full-fledged consideration and resolution of cases arising from the existing legal relations. The purpose of this article, which consists in analyzing the practical features of the qualification of acts under Article 315 of the Criminal Code of the Russian Federation, largely depends on understanding the essence of the correct and timely execution of a court decision. As a general rule, any decision made by the courts on behalf of the Russian is correct, lawful and justified. Nevertheless, the law separately specifies the procedural aspects of making court decisions and establishes requirements regarding their legality and validity. In addition, the practical significance of the topic is confirmed by the importance of resolving competition between general and special rules. Taking into account these aspects, it is important to note that the protection of the rights of persons involved in the case is carried out, including through reasonable and balanced judicial decisions. In other words, non-execution of court decisions violates the basic foundations of the administration of justice in the Russian Federation, therefore, must be punished by law.
GOVERNANCE OF PROTECTIONIST MEASURES WITHIN THE WTO
Authors:   Saint-Petersburg State University of Aerospace Instrumentation, Saint Petersburg, Russian Federation, KOLESNIKOVA TATIANA
Published: February 2023

The purpose of the study is to determine the prospects for development of protectionism as the dominant paradigm of countries’ economic policies in the context of supranational regulation of international trade within the World Trade Organization (the WTO, Organization). During the study it was found out that the tools of modern protectionism include non-tariff import restriction measures, as well as fiscal and administrative measures to support production and export. The use of these tools contributes to an increase in compensation protectionist measures by trading partners. It was revealed that the WTO mechanisms limit the range of protectionist measures by participating in the provision of balance of interests of the WTO member states. The article concluded that in spite of the WTO crisis, manifested in the inability to reach new agreements based on the principle of consensus due to differences in the goals and interests of the participating member states, the WTO is interested in the safety and functioning of this institution. Participation in the Organization provides relatively non-discriminatory access of goods on foreign markets, and also allows you to defend the interests of the country during discussion of the modernization issues within the existing international trading system. At the same time, as it was noted, in the context of the WTO crisis, alternative platforms for implementation of economic interests of states are becoming regional economic units of different forms of integration.
STUDI KEPADATAN DAN POLA DISTRIBUSI BIVALVIA PADA EKOSISTEM MANGROVE DI PERAIRAN DESA TANJUNG PINANG KECAMATAN KUSAMBI KABUPTEN MUNA BARAT
Authors: Solata Indra , Ramli Muhammad , Oetama Dedy
Published: February 2023

Bivalvia merupakan golongan kekerangan remis, dan sebangsanya. Penelian ini dilaksanakan pada bulan November-April 2022 di perairan Desa Tanjung Pinang, Kecamatan Kusambi, Kabupaten Muna Barat. Analisis tekstur substrat di lakukan di Laboratorium Perikanan dan Ilmu Kelautan Universitas Halu Oleo. Pengambilan sampel bivalvia dilakukan dengan dua kali pengulangan dari masing-masing stasiun. Pengambilan dilakukan dengan meletakan transek kuadrat ukuran 1 x 1 meter sebanyak 5 transek pada petak contoh 10 x 10 meter sebagai daerah patokan pengambilan sampel bivalvia. Hasil Penelitian ditemukan tiga jenis bivalvia Anadara Granosa, Polymesoda Bengalensis, dan Tellina Laevigate dengan nilai komposisi jenis berkisar antara 24  -  40 %. Nilai kepadatan bivalvia berkisar antara 5.3  –  10.1 ind/m2. Jenis mangrove yang temukan adalah jenis Rhizophora mucronata, Rhizophora Apiculata dan Sonneratia Alba dengan nilai kerapatan berkisar antara 800  –  2600 pohon/ha. Tingginya mangrove pada stasiun III mempengaruhi keberadaan bivalvia di perairan tersebut.Kata kunci : Jenis Biavalvia, Kepadatan Biavalvia, Mangrove dan Perairan Desa Tanjung Pinang.
Antibacterial Activity of Ethanolic Extract Siwak Stem (Salvadora persica) Against Staphylococcus aureus ATCC 25923
Authors: Nisa’ Nur Sholikhah  , Andang Arif Wibawa  , Rukmana Rizal Maarif
Published: February 2023

Infection is caused by bacteria, one of which is Staphylococcus aureus. Infectious treatment can use Siwak as natural plants (Salvadora persica), namely Siwak plants. Salvadora persica contains Saponins, Alkaloids, Tanins, and Fenols. This study is to know the antibacterial activity of Salvadora persica stems against Staphylococcus aureus ATCC 25923 growth. Extraction method using maceration with ethanol as a solvent. The group of extract compounds was identified using various chemical reagents. Salvadora persica stem extract was made in various concentrations of 6,25%, 12,5%, 25%, and 50% by using dimethyl sulfoxide 2% (DMSO) as thinner. Chlorhexidine 0,2% was a positive control, and DMSO 2% was a negative control. Antibacterial activity test was obtained by diffusion method. Analysis data used way ANOVA test. The results ethanolic extract of the siwak stem contains a class of compounds: saponins, alkaloids, tannins, and phenols. The result showed that Salvadora persica stem extracts antibacterial activity against Staphylococcus aureus ATCC 25923. Antibacterial activity test against Staphylococcus aureus from laboratory culture showed an average of largest inhibition zone diameter on 50% concentration with 20,5 mm diameter and smallest inhibition zone at 6,25% concentration with 14 mm diameter.
High-resolution imaging in studies of alcohol effect on prenatal development
Authors: Meombe Mbolle Augustine , Thapa Shiwani , Bukiya Anna N. , Jiang Huabei
Published: February 2023

Fetal alcohol syndrome represents the leading known preventable cause of mental retardation. FAS is on the most severe side of fetal alcohol spectrum disorders that stem from the deleterious effects of prenatal alcohol exposure. Affecting as many as 1 to 5 out of 100 children, FASD most often results in brain abnormalities that extend to structure, function, and cerebral hemodynamics. The present review provides an analysis of high-resolution imaging techniques that are used in animals and human subjects to characterize PAE-driven changes in the developing brain. Variants of magnetic resonance imaging such as magnetic resonance microscopy, magnetic resonance spectroscopy, diffusion tensor imaging, along with positron emission tomography, single-photon emission computed tomography, and photoacoustic imaging, are modalities that are used to study the influence of PAE on brain structure and function. This review briefly describes the aforementioned imaging modalities, the main findings that were obtained using each modality, and touches upon the advantages/disadvantages of each imaging approach.
Formononetin isolated from Sophorae flavescentis inhibits B cell-IgE production by regulating ER-stress transcription factor XBP-1
Authors: Yang Nan , Musa Ibrahim , Maskey Anish R. , Li Ke , Wang Zhenzhen , Liang Banghao , Zhang Shuwei , Zhan Jixun , Li Xiu-Min
Published: February 2023

Rationale

IgE plays an important pathologic role in most, if not all, allergic conditions. We previously showed that ASHMI (anti-asthma herbal medicine intervention) suppressed IgE production in murine models of asthma and in asthma subjects. However, the active compounds in ASHMI responsible for the IgE suppression are still unknown.

Objective

We sought to identify the compound(s) in ASHMI that are responsible for IgE inhibition as well as investigate the mechanisms by which the identified compound(s) decreases IgE production.

Methods

The compounds in Sophorae Flavescentis were separated using Column chromatography and preparative-HPLC. The separated compounds were identified using LC-MS and 1H-NMR. U266 cells, an IgE-producing plasma cell line, were cultured with various concentrations of identified compounds. The levels of IgE production by the U266 cell were measured by ELISA. Trypan blue exclusion was used to determine the cell viability. The gene expression of XBP-1 and IgE-heavy chain was determined by RT-PCR.

Results

A single compound identified as formononetin was isolated from Sophorae Flavescentis. Formononetin significantly and dose dependently decreased the IgE production in U266 cells across a concentration range of 2–20 µg/ml (p < 0.05–0.001 vs. untreated cells) with an IC50 value of 3.43 μg/ml. There was no cytotoxicity at any tested concentration. Formononetin significantly decreased XBP-1, and IgE-heavy chain gene expression compared with untreated cells (p < 0.001).

Conclusion

Formononetin decreased IgE production in human B cell line U266 cells in a dose-dependent fashion through the regulation of XBP-1 ER transcription. Formononetin may be a potential therapy for allergic asthma and other IgE-mediated diseases.
Recent advances in antibacterial coatings for orthodontic appliances
Authors: Wang Nannan , Yu Jingjing , Yan Jiarong , Hua Fang
Published: February 2023

In the process of orthodontic treatment, the presence of orthodontic appliances makes it difficult to clean tooth surfaces. This can lead to an increased level of bacterial colonization, resulting in enamel demineralization and periodontal diseases. Considering the large surface area that orthodontic appliances usually have and that they can be in direct contact with bacteria throughout the treatment, modifications in the form of coatings on the surface of orthodontic appliances can be an effective and practical approach to reducing bacterial proliferation and preventing relevant adverse effects. In this mini-review, we discuss various antibacterial coatings which have been applied onto orthodontic appliances in recent 5 years, as well as their antibacterial mechanisms and methods for the preparation of these coatings. From this mini-review, both orthodontists and researchers can get the latest findings in the field of antibacterial coatings onto orthodontic appliances, which is helpful for the decision-making in clinical practice and research activities.
Efficient removal of bovine serum albumin from water by cellulose acetate membranes modified with clay and titania nano particles
Authors: Refaat Heba M. , Ashraf Nada , El-Dissouky Ali , Tieama Hossam A. , Kamoun Elbadawy A. , Showman M. S.
Published: February 2023

Modified cellulose acetate membranes with bentonite clay (CA/bent) and TiO2 nanoparticles (CA/TiO2) using the phase inversion method are successfully prepared and characterized. These Membranes are favored due to their high salt rejection properties and recyclability. The IR and EDX spectral data indicate the formation of modified membranes. The Scan Electron Microscope micrographs show that the modified membranes have smaller particle sizes with higher porosity than the neat membrane. The average pore diameter is 0.31 µm for neat cellulose acetate membrane (CA) and decreases to 0.1 µm for CA/0.05bent. All modified membranes exhibit tensile strengths and elongation percentages more than the neat membrane. The higher tensile strength and the maximum elongation% are 15.3 N/cm2 and 11.78%, respectively, for CA/0.05bent. The thermogravimetric analysis of modified membranes shows higher thermal stability than the neat membrane. The modified membranes exhibit enhanced wettability and hydrophilicity compared with cellulose acetate, by measuring the contact angle which decreases from 60° (CA) to 40° (CA/0.1bent). The ultrafiltration tests indicated that the CA/bent and CA/TiO2 are better than CA. The most efficient nanocomposite membrane is CA/0.05bent with 100% removal of (BSA) from industrial water with a flux equal to 9.5 mL/min under an applied pressure of 20 bar. Thus, this study introduces a novel ultrafiltration membrane (CA/0.05bent) that can be used effectively to completely remove bovine serum albumin from contaminated water.
Regulatory effects of oral microbe on intestinal microbiota and the illness
Authors: Lu Yanbei , Li Zhengyi , Peng Xian
Published: February 2023

Over the past decade, the association between oral health, intestinal microbiota, and systemic diseases has been further validated. Some oral microbial species have been isolated from pathological intestine mucosa or feces and identified as biomarkers for intestinal diseases. A small proportion of oral microbiome passes through or colonizes the lower gastrointestinal tract, even in healthy individuals. Opportunistic pathogens from the oral cavity may expand and participate in the occurrence and progression of intestinal diseases when the anatomical barrier is disrupted. These disruptors interact with the intestinal microbiota, disturbing indigenous microorganisms, and mucosal barriers through direct colonization, blood circulation, or derived metabolite pathways. While interacting with the host’s immune system, oral-derived pathogens stimulate inflammation responses and guide the transition of the intestinal microenvironment from a healthy state to a pre-disease state. Therefore, the oral-gut microbiome axis sheds light on new clinical therapy options, and gastrointestinal tract ecology balance necessitates simultaneous consideration of both oral and gut microbiomes. This review summarizes possible routes of oral microbes entering the intestine and the effects of certain oral bacteria on intestinal microbiota and the host’s immune responses.
circRNA, a novel diagnostic biomarker for coronary heart disease
Authors: Tong Xiao , Zhao Xinyi , Dang Xuan , Kou Yan , Kou Junjie
Published: February 2023

Objective

This study aimed to identify the potential diagnostic biomarkers of coronary heart disease (CHD) from exosome-derived circRNA.

Methods

The microarray data of circRNA derived from the exosomes of patients with CHD and mRNA in acute myocardial infarction was retrieved from exoRBase website and GEO database (GSE61144), respectively, to identify the differentially expressed genes (DEGs). Our findings detected the differentially expressed circRNAs and mRNAs and predicted their correlation with microRNAs using the microRNA target prediction website, thus ascertaining the corresponding circ-microRNA and micro-mRNAs. Then, we performed systematic Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis on the differentially expressed mRNA. Protein-Protein Interactions (PPI) of these DEGs were examined using STRING. The receiver operator characteristic (ROC) curve was used to validate the diagnostic efficacy of circRNA in patients with CHD. Finally, the RNAs identified in this study were verified by quantitative real-time polymerase chain reaction (qRT-PCR).

Results

A total of 85 differentially expressed circRNAs (4 up-regulated and 81 down-regulated) were identified by screening the circRNAs in exosome of CHD patients. Based on the prediction data of circRNA, mRNA, and the corresponding microRNA, a ceRNA network was constructed, including 7 circRNA nodes, 5 microRNA nodes, and 2 mRNA nodes. Finally, validated by qRT-PCR testing, we found circRNA0001785, circRNA0000973, circRNA0001741, and circRNA0003922 to be the promising candidate for the effective prediction of CHD. These potential diagnostic markers can provide insight for further research on the occurrence of CHD or even acute coronary syndrome (ACS).
Citalopram in the treatment of elderly chronic heart failure combined with depression: A systematic review and meta-analysis
Authors: Yan Longmei , Ai Yuzhen , Xing Yaxuan , Wang Biqing , Gao Anran , Xu Qiwu , Li Hongzheng , Chen Keji , Zhang Jingchun
Published: February 2023

Background

Depression is an independent factor to predict the hospitalization and mortality in the chronic HF patients. Citalopram is known as an effective drug for depression treatment. Currently, there is no specific recommendation in the HF guidelines for the treatment of psychological comorbidity. In recent years, many studies have shown that the citalopram may be safe in treating of chronic HF with depression.

Objective

To evaluate the efficacy and safety of the citalopram in the treatment of elderly chronic HF combined with depression.

Methods

PubMed, EMBASE, Cochrane, Web of Science, CNKI, VIP, CBM, and Wanfang were searched from their inception to May 2022. In the treatment of elderly chronic HF combined with depression, randomized controlled studies of the citalopram were included. Independent screening and extraction of data information were conducted by two researchers, and the quality was assessed by the Cochrane bias risk assessment tool. Review manager 5.4.1 was employed for statistical analysis.

Results

The results of meta-analysis prove that the citalopram treatment for depressed patients with chronic HF has a benefit for HAMD-24 (MD: −8.51, 95% CI: −10.15 to −6.88) and LVEF (MD: 2.42, 95% CI: 0.51 to 4.33). Moreover, the score of GDS decreases, and NT-proBNP (MD: −537.78, 95% CI: −718.03 to −357.54) is improved. However, the comparison with the control group indicates that there is no good effect on HAMD-17 (MD: −5.14, 95% CI: −11.60 to 1.32), MADRS (MD: −1.57, 95% CI: −3.47 to 0.32) and LVEDD (MD: −1.45, 95% CI: −3.65 to −0.76). No obvious adverse drug reactions were observed.

Conclusion

Citalopram treatment for depressed patients with chronic HF has a positive effect on LVEF and NT-proBNP. It can alleviate HAMD-24 and GDS, but the relative benefits for LVEDD, HAMD-17 and MADRS still need to be verified.

Systematic Review Registration: PROSPERO [CRD42021289917].
Mesenchymal stem cell-based therapy for non-healing wounds due to chronic limb-threatening ischemia: A review of preclinical and clinical studies
Authors: Huerta Carlos Theodore , Voza Francesca A. , Ortiz Yulexi Y. , Liu Zhao-Jun , Velazquez Omaida C.
Published: February 2023

Progressive peripheral arterial disease (PAD) can result in chronic limb-threatening ischemia (CLTI) characterized by clinical complications including rest pain, gangrene and tissue loss. These complications can propagate even more precipitously in the setting of common concomitant diseases in patients with CLTI such as diabetes mellitus (DM). CLTI ulcers are cutaneous, non-healing wounds that persist due to the reduced perfusion and dysfunctional neovascularization associated with severe PAD. Existing therapies for CLTI are primarily limited to anatomic revascularization and medical management of contributing factors such as atherosclerosis and glycemic control. However, many patients fail these treatment strategies and are considered “no-option,” thereby requiring extremity amputation, particularly if non-healing wounds become infected or fulminant gangrene develops. Given the high economic burden imposed on patients, decreased quality of life, and poor survival of no-option CLTI patients, regenerative therapies aimed at neovascularization to improve wound healing and limb salvage hold significant promise. Cell-based therapy, specifically utilizing mesenchymal stem/stromal cells (MSCs), is one such regenerative strategy to stimulate therapeutic angiogenesis and tissue regeneration. Although previous reviews have focused primarily on revascularization outcomes after MSC treatments of CLTI with less attention given to their effects on wound healing, here we review advances in pre-clinical and clinical studies related to specific effects of MSC-based therapeutics upon ischemic non-healing wounds associated with CLTI.
The impact of the soluble epoxide hydrolase cascade on periodontal tissues
Authors: Abdalla Henrique Ballassini , Van Dyke Thomas E.
Published: February 2023

Periodontitis is a chronic inflammatory disease with complex pathogenesis. Uncontrolled inflammation is driven by the immune system in response to accumulation of oral biofilm that leads to alveolar bone loss, bleeding, increased periodontal probing depth with loss of attachment of the connective tissues to the tooth, and ultimately, tooth loss. Soluble epoxide hydrolase (sEH) is an enzyme that converts epoxy fatty acids (EpFAs) produced by cytochrome P450 (CYP450) to an inactive diol. It has been shown that EpFAs display important features to counteract an exaggerated inflammatory process. Based upon this observation, inhibitors of sEH have been developed and are being proposed as a strategy to regulate proinflammatory lipid mediator production and the chronicity of inflammation. This mini review focuses on the impact of sEH inhibition on periodontal tissues focusing on the mechanisms involved. The interaction between Specialized Pro-Resolving Mediators and sEH inhibition emerges as a significant mechanism of action of sEH inhibitors that was not formerly appreciated and provides new insights into the role SPMs may play in prevention and treatment of periodontitis.
Posterior regularization method for phase removal of shale nano-structure imaging in space domain
Authors: Fan Shufang , Tang Wei , Wang Yanfei , Nashed M. Zuhair
Published: February 2023

X-Ray computed tomography is a non-destructive method that is used, among many applications, to study the size, shape, 3D structures and interconnections of pores in shale. We use phase retrieval methods to deal with the “edge enhancement” effect caused by phase shift. The process of phase retrieval can be described by the transport-of-intensity equation (TIE). But this is an ill-posed problem. The existing methods focus on phase retrieval in the frequency domain. To tackle the ill-posedness, we propose a new method whose main idea is to solve this problem in space domain with a regularization technique. We study a synthetic shale model and simulate the projection data. Then we apply three methods to retrieve the phase: conventional method in frequency domain, direct solving method and iterative Tikhonov regularization method in space domain. Finally, we use the standard filtered back-projection (FBP) method to present the outcome. By analyzing the results, we find advantages of the new method: more stability and fewer artifacts under noise perturbations. The study shows that relative errors of the new method are nearly 1% of that of the traditional method based on frequency domain, and hence the new method is promising for the practical data processing.
Analysis of the 2021 Milford, Utah earthquake swarm: Enhanced earthquake catalog and migration patterns
Authors: Whidden Katherine M. , Petersen Gesa M. , Mesimeri Maria , Pankow Kristine L.
Published: February 2023

An earthquake swarm occurred in Spring 2021 in south-central Utah near the town of Milford. The University of Utah Seismograph Stations located 125 earthquakes between March 19 and May 10 with magnitudes ranging from 0.5 to 3.2. We implement a matched-filter technique in order to identify additional earthquakes that went undetected during the routine network location. The 125 network-located earthquakes are used as templates and are cross-correlated with continuous data for the dates Feb 17—June 10. This time period corresponds to approximately 1 month before the earthquake swarm began through 1 month after it ended. For the matched-filter analysis, we rely heavily on station FOR1, which is located within 5 km of most template events. Four other stations within 20–30 km of most template events provide a supplement to the closest station. The matched-filter implementation results in the detection of over 600 earthquakes in addition to the original 125 catalog events. This is one of the largest swarms ever recorded in Utah, and no previous large swarms have been recorded in this location. We use HypoDD to obtain relative double-difference locations of the catalog events. Both routine locations and HypoDD relocations of the catalog events suggest a fault dipping west beneath the mountain range, opposite of typical Basin and Range normal faults that dip beneath alluvial valleys. Moment tensors for the largest five events show normal faulting consistent with the west-dipping fault seen in the seismicity. Hydrothermal features in the area, including a geothermal power plant, suggest that fluids may be a contributing factor to the earthquake swarm triggering. We examine the role of fluids by exploring bounds on diffusion parameters and investigating spatial migration characteristics of the swarm seismicity. We conclude that this swarm is the result of heterogenous stress conditions in a prefractured region.
GLP−1 receptor agonists for the treatment of obesity: Role as a promising approach
Authors: Wang Jing-Yue , Wang Quan-Wei , Yang Xin-Yu , Yang Wei , Li Dong-Rui , Jin Jing-Yu , Zhang Hui-Cong , Zhang Xian-Feng
Published: February 2023

Obesity is a complex disease characterized by excessive fat accumulation which is caused by genetic, environmental and other factors. In recent years, there has been an increase in the morbidity, disability rate,and mortality due to obesity, making it great threat to people’s health and lives, and increasing public health care expenses. Evidence from previous studies show that weight loss can significantly reduce the risk of obesity-related complications and chronic diseases. Diet control, moderate exercise, behavior modification programs, bariatric surgery and prescription drug treatment are the major interventions used to help people lose weight. Among them, anti-obesity drugs have high compliance rates and cause noticeable short-term effects in reducing obese levels. However, given the safety or effectiveness concerns of anti-obesity drugs, many of the currently used drugs have limited clinical use. Glucagon-like peptide-1 receptor (GLP-1R) agonists are a group of drugs that targets incretin hormone action, and its receptors are widely distributed in nerves, islets, heart, lung, skin, and other organs. Several animal experiments and clinical trials have demonstrated that GLP-1R agonists are more effective in treating or preventing obesity. Therefore, GLP-1R agonists are promising agents for the treatment of obese individuals. This review describes evidence from previous research on the effects of GLP-1R agonists on obesity. We anticipate that this review will generate data that will help biomedical researchers or clinical workers develop obesity treatments based on GLP-1R agonists.