bluuebunny/crossref_metadata_2025 huggingface dataset:
The Development of Most-favored-nation Treatment——From Substance to Procedure
Authors: Cao Jing
Published: April 2022

MFN treatment in international investment law is implemented by the host country to foreign investors, the treatment is

not less than treatment already given or will give the third countries investors. More and more investors sought to take advantage

of the general provisions of MFN clause in bilateral investment treaties in an attempt to enjoy more favorable treatment for dispute

settlement in third treaties. This paper expounds on the basis of cases to analyze whether MFN clause could be applied to the

dispute settlement procedure or MFN treatment could extend to procedural rights.
Analysis of Children’s Picture Book from the Perspective of Systemic Functional Grammar—A Case Study of The Coronavirus Fight
Authors: Hu Ling
Published: April 2022

The Coronavirus Fight is a well-made children’s picture book about epidemic publicity. This article attempts to analyze

the text message from the perspective of Systemic Functional Grammar (SFG). For ideational function, this book uses the material,

relational and behavior process the most. The heavy use of the transitivity process vividly depicts the epidemic situation. For

interpersonal function, most sentences use declarative mood, which indicates that this book aims to express much more information

to the readers. Furthermore, a large amount of the first person also bridges the void between the writer and reader. The analysis of

the text reveals well the meaning which the story conveys: although the coronavirus does harm to human health, our country is

taking effective measures to prevent it, and we should believe we will fight against it one day.
Research on Sub-pixel Edge Feature Extraction and Measurement Based on Polynomial Fitting
Authors: Cao Lexin , Geng Wenli , Zhang Hanwen , Chang Xiaodan , Tang Yijun
Published: April 2022

In the field of image processing,a very classic problem is image segmentation.Moreover,the extraction of image edge

features is a very important link in image segmentation.This paper construct a sub-pixel edge feature extraction model based

on polynomial fitting,and solve the problems of edge extraction and corrected scale measurement.
Comparison of TOEFL iBT and ESOL in Reliability
Authors: Li Zixin
Published: April 2022

TOEFL iBT and ESOL are two language proficiency tests, and they are widely accepted by test takers worldwide. Both

tests assess test takers’ speaking skills, but they vary to some extent. This study will compare these two tests in terms of reliability

criteria.
The Multimodal Analysis of War And Peace
Authors: Ding Ziyue
Published: April 2022

War And Peace, originally a most praised and studied masterpiece in the history of Western Literature, nowadays

represents a literary-artistic phenomena far more than the text composed by Tolstoy. Utilising the multimodal discourse analysis,

now the mainstream of deconstruction method of contemporary linguistics and semiotics research, this thesis analyses the

translations and multimedia adaptions to cover the shortages of previous text studies and simultaneously analyses the application

of multimodal discourse in the adaptation and dissemination of literary works in a two-way perspective.
Innovative Research on Teaching Methods of Classical Dance
Authors: Zhang Xindan
Published: April 2022

The development of classical dance teaching is not only to increase their own development projects, but also has great

significance for the inheritance of traditional culture. However, at present, there are bottlenecks in the teaching methods of classical

dance. In order to promote the development of the art of classical dance under the multi-culture, it is necessary to reform the

teaching method of classical dance innovatively. In order to achieve the overall improvement of students’ comprehensive quality,

inheritance of China’s excellent traditional culture.
Social Wealth Structure of the Ming Dynasty and its Influence on the Historical Development of China
Authors: Zhao Zeming
Published: April 2022

After the middle of the Ming Dynasty, with the rapid development of market commodity economy, Jiangnan town

economy and silver monetization, the social production and life relations had undergone profound changes, and the polarization

of social wealth became more and more serious.A hundred years and seriously solidified centralized system and party struggle and

corrupt bureaucracy promoted this unfair distribution, intensified social conflicts, and eventually led to the demise of the Ming

Dynasty.The article divides the social groups of the Ming Dynasty into different classes, analyzes the composition of its wealth

structure, and discusses the influence of this structure on the historical development of China.
The Development of Service Design in the Medical and Health Industry
Authors: Sun Xiaotong
Published: April 2022

With economic development and social progress, medical and health design has received more and more attention and

has become a national health and safety issue. Today, people are no longer limited to “seeking medical treatment”, but when they

are healthy. “Preventing disease”, seeking a better quality of life through medical means, as a result of which medical products and

services are more closely linked to people’s lives, and China’s medical and health industry has ushered in a historic opportunity

for rapid development. The current medical services have some drawbacks, so the methodology provided by the service design

concept can guide how to better serve the medical field, aiming to provide solutions based on the service design concept, and then

meet the expectations of patients for the medical service experience.
A Study on Senior High School English Reading Teaching Pointing to the Cultivation of Thinking Quality
Authors: Xue Shan
Published: April 2022

The English Curriculum Standards (2017 edition) for the first time clearly listed the quality of thinking as one of the core

competencies of the discipline. However, the current problem facing high school English teaching is how to effectively cultivate

students’ quality of thinking. Therefore, teachers need to actively implement the cultivation of core competence, strive to combine

English reading teaching and the cultivation of thinking quality, and cultivate the thinking quality of students through English

reading teaching.
Analysis of Chinese Tourists' Expectations and Satisfaction with Thai Tourism
Authors: Zhang Taolin
Published: April 2022

With the development of economy, more and more Chinese tourists choose Thailand as their tourism destination, which

is both an opportunity and a challenge for the development of tourism in Thailand. Under this background, it is meaningful to

explore and analyze the tourism expectations and satisfaction of Chinese tourists after their on-site experience in Thailand.

On the basis of previous studies, this study compares the expected value of different tourism factors with the actual experience

satisfaction model, combines the results of the questionnaire survey, carries out data analysis with the help of software, verifies the

research hypothesis and draws conclusions. The study finds that Chinese tourists' satisfaction in Thailand is highly correlated with

the expectations of various tourism factors, and both of them are influenced by the differences of Chinese tourists' demographic

information. At the same time, the overall satisfaction is affected by various specific satisfaction factors, showing a linear additive

relationship. Finally, this study analyses the conclusions and problems found, and puts forward some countermeasures and

suggestions based on Thailand's relevant policies, economic and cultural status, to provide a suggestion for the sustainable and

healthy development of Thailand's tourism market to China.
Factors Impact Investor Decision to Hospitality & Tourism Transaction in SET50 Index Stock Market in Thailand
Authors: Zhao Fengyu
Published: April 2022

In early 2020, the outbreak of new coronavirus did not reverse the trend of global spread until May 2021, and even the

situation in some countries was worse than that in 2020 which is a comprehensive challenge to human health, economic growth,

social development, national security and international relations.

Under the premise of a poor global economic environment, it is important for tourism practitioners and investors to make the right

decision and make a profit in the Thai stock ticket market SET50.On the basis of previous studies on Thai stock market and Thai

Investors’ financial behavior, this paper draws on previous research results.

For investors, when monetary policy is introduced, they can refer to this study to modify their investment analysis. It also has a

certain reference value for hospitality and tourists.
A Study on Teaching Strategies of High School Geography Centered on the “Problem Study” Section of the New Textbook
Authors: Deng Ting
Published: April 2022

The new high school geography textbook continues to use the “problem study” section, which has an important status

and role in teaching. This paper first discusses the characteristics of the “Problem Study” section of the new textbook, and then

focuses on the teaching strategies based on the “Problem Study” section of the new high school geography textbook, aiming to

provide effective reference for front-line teachers to carry out high school geography teaching.
Research on the Cultivation of College Students' Scientific Research and Innovation Ability
Authors: Li Guang , Chen Ruirui
Published: April 2022

The cultivation of innovative talents in secondary colleges and universities is one of the core tasks of the current reform

and development of our society and country. The training of innovative ability plays a vital role in the cultivation of students'

innovative thinking consciousness and practical ability. It plays an obvious role in promoting the educational concept, training

mode, innovative atmosphere, improving the guiding role of relevant instructors, and establishing an efficient student scientific

research team.
Analysis of Negative Sentence in English Teaching and Learning
Authors: Yuan Yirong
Published: April 2022

A grammatical category—negative sentence was identified in the article; It explained why it is problmatic for my EFL/

ESL students, in terms of form, meaning and use and finally discussed its pedagogic implications in the EFL/ESL class.
Examining the Psychometrics of the Connor-Davidson Resilience Scale (CD-RISC) among Medical Staff Members at the Faculty of Medicine, Suez Canal University, Egypt
Authors: Gouda Enas , Kamal Doaa , Fouad Sally , Elaraby Shimaa
Published: April 2022

Objectives: This study aims to investigate the level of Career Resilience among Medical Staff members and examine the psychometrics of the Connor-Davidson Resilience Scale (CD-RISC). Subjects and Methods: This is a descriptive, cross-sectional study; the study population included medical staff from basic and clinical departments at the Faculty Of Medicine, Suez Canal University (FOM-SCU) (n=75). The instrument was Connor-Davidson Resilience Scale (CD-RISC) to assess medical staffs’ career resilience. Results: This study reveals that the medical staff at FOM-SCU agreed that things happen for a reason, past success gives them confidence for new challenge and, sometimes fate or God can help (78%, 72% and 72%, respectively). Ninety two percent of participants had a resilience score of ?50%. Exploratory Factor Analysis (EFA) of the CD-RISC was conducted. This analysis yielded four factors. These factors were labeled as follows: Factor 1: Personal Competence, Factor 2: Tolerance of Negative Affect; Factor 3: Acceptance of change, secure relationships, and spiritual influences; and Factor 4: Control. Conclusion: The findings revealed that the medical staff received a high level of career resilience, and they especially felt that God gives them confidence. Resilience reveals how the medical staff copes with change and how they face challenges and risk events in the health profession. This study assessed the psychometric properties of the CD-RISC questionnaire and concluded that it is a reliable and valid instrument to measure career resilience in medical staff.
Density and Distribution of Principal Prey Species of Tigers and Leopards in Pench Tiger Reserve, Madhya Pradesh
Authors: Chatterjee Anindita Bidisha , Sankar Kalyansundaram , Qureshi Qamar
Published: April 2022

Conservation of large carnivores is dependent on a viable population of their principal prey species. Line transect based density estimation has been established as a robust method for monitoring prey population trend. Chital (Axis axis) and sambar (Rusa unicolor) are the major ungulates in Pench tiger reserve, Madhya Pradesh that are principal tiger and leopard prey. Estimated densities using line transect surveys were highest for chital in the study area with a range of 44–52 individuals per sq. km. from 2013–16. Sambar density remained stable ranging from 5–8 individuals per sq. km. over the three years (2013–16). Camera trap-based encounter rate was used to calculate the Relative Abundance Index of the principal prey species of tigers and leopards in the study area. Spatial distribution pattern using the Relative Abundance Index showed that 47.16% chital captures were congregated near the submergence area whereas 38.53% sambar captures were near rugged areas. Abundant resources and lack of competition from domestic livestock in the core zone contribute to such high estimates of prey population in the study area.
Dentigerous Cyst Associated with Compound Odontome in the Anterior Region of Maxilla – A Case Report
Authors: Loganathan Mahalakshmi , Harikrishnan Prasad , Muthusamy Rajmohan , Nagarajan Senthilkumar
Published: April 2022

Dental professionals encountered tumor and cystic lesions in their daily practice. However, a concurrent lesion are quite rare and poses diagnostic challenge. Odontoma are the most common odontogenic tumor of the jaw. Although transformation from cyst to tumor is quite common (orgin of ameloblastoma from a dentigerous cyst) but tumor to cyst is very rare1. Here, we report a case of a dentigerous cyst associated with odontome and an unerupted tooth in the anterior region of the maxilla.
Nurses’ Perception of Learning Organization Dimensions
Authors: Salem Olfat A , Alatawi Sarah Ruwayi F , Nazik Zakari MA
Published: April 2022

Converting the healthcare delivery system into a learning organization is essential for improving health outcomes. As nurses are the forces that implement changes to meet organizational objectives, they are continuously involved in the learning process. This study aims to explain the learning organization dimensions as perceived by Nursing staff in Saudi Arabia. This is a descriptive study that uses a convenience sample of 550 nurses. Data was collected using The Dimensions of the Learning Organization Questionnaire (DLOQ). The questionnaire consists of seven dimensions of learning organization. The DLOQ is based on a six-point Likert scale which was scored from 1-6. The study found the highest perceived dimension was “Embedded Systems.” While the lowest perceived dimension was “Empowerment.” The study concluded that while some dimensions were perceived highly by nurses like embedded systems, some dimensions, like system connections and empowerment, were perceived lowly which indicates areas of weaknesses in the organization.
Análise dos Parâmetros de Irregularidade Longitudinal na Rua Bonaire em Açailândia-MA com o Uso do Equipamento MERLIN Modificado
Authors: Silva Lucas Carvalho , Souza Átila Marconcine de , Soares João Victor da Silva , Silva Lucas Manoel da , Crispim Flavio Alessandro , Ferreira Ludimilla da Silveira
Published: April 2022

No Brasil o modal rodoviário é o que possui a maior participação na matriz de transporte. O enfoque dessa pesquisa foi a Rua Bonaire, no município de Açailândia-MA, por ter conexão com a rodoviária e a zona central do município em questão. O objetivo do presente trabalho foi classificar o estado de qualidade de um trecho dessa rua, por meio da verificação dos parâmetros de irregularidade longitudinal através de uma metodologia prática, moderna e eficiente, empregando um equipamento MERLIN modificado com uma trena a laser. Os dados de medição foram analisados conforme a metodologia de Cundill, ou seja, através de um histograma de frequência, onde os dados foram marcados de acordo com a depreciação do trecho ou elevação do trecho. Para isso foram realizadas aferições em um trecho de 200 metros com o MERLIN modificado, calculando os parâmetros de: Índice de Irregularidade Internacional (IRI) e o Quociente de Irregularidade (QI) destes trechos analisados.  Determinou-se com este trabalho que o conceito da condição de serventia da Rua Bonaire é péssimo e que as modificações feitas no MERLIN tradicional, tornaram o processo de coleta de dados mais prático e eficiente, facilitando assim o cálculo do IRI e QI. Por fim, através deste estudo, diversas oportunidades serão criadas acerca de futuras pesquisas sobre as condições de rodagens de outras vias, principalmente devido ao salto técnico que foi obtido do equipamento MERLIN tradicional para o MERLIN confeccionado neste trabalho.
Wpływ procesu integracji Polski z Unią Europejską na rozwój rynków nieruchomości
Authors: Kucharska-Stasiak Ewa , Załęczna Magdalena , Żelazowski Konrad
Published: April 2022

Publikacja skupia się na zmianach, zachodzących na rynkach nieruchomości po 2004 roku. Podjęto w niej próbę odpowiedzi na pytanie o czynniki wpływające na proces zmian, jakim podlegały rynki nieruchomości ze wskazaniem roli akcesji do UE. Okres, podlegający ocenie jest szczególny, bowiem – oprócz efektów, związanych z integracją, ujawnił się silnie wpływ kryzysu światowego, korygujący zachowania uczestników rynku.
ÖRGÜTSEL VATANDAŞLIK DAVRANIŞI, AÇIK İNOVASYON VE FİRMA PERFORMANSI İLİŞKİSİ
Authors: İMAMOĞLU Salih Zeki , TÜRKCAN Hülya , BİRGÜLEN Özlem
Published: April 2022

Firmanın sahip olduğu insan kaynağı, onun çıktıları için temel belirleyici faktördür. Bu doğrultuda, firma yararı için gönüllü olarak ekstra çaba sarf eden çalışanlar başarılı çıktılar elde etmek için önemlidir. Küresel rekabet şartlarında firmanın kaynak kısıtını ortadan kaldıran açık inovasyon firmanın başarılı olmasını sağlarken, iletişim, işbirliği ve koordinasyona dayalı olduğundan açık inovasyonun başarılı yürütülmesi de çalışanların ekstra çabalarıyla mümkündür. Buradan hareketle bu çalışmanın amacı, örgütsel vatandaşlık davranışı, açık inovasyon ve firma performansı arasındaki ilişkiyi araştırmaktır. Araştırma kapsamında, Kocaeli bölgesindeki imalat sanayinde faaliyette bulunan 188 firmadan anket yoluyla veri toplanmıştır. Toplanan veriler AMOS istatistiksel paket programında analiz edilmiştir. Analiz sonuçlarına göre, örgütsel vatandaşlık davranışı açık inovasyonu ve açık inovasyon da firma performansını pozitif yönde etkilemektedir. Ayrıca, örgütsel vatandaşlık davranışı ve firma performansı ilişkisinde açık inovasyonun tam ara değişken rolü olduğu bulunmuştur.
In horses with secondary sinusitis caused by dental disease, is computed tomography more accurate than radiography for the identification of apical dental pathology?
Authors: Gill-Parsons Rebecca , Shipman Emma , Pickles Kirstie
Published: April 2022

PICO question

In adult horses with secondary sinusitis caused by dental disease, is computed tomography more accurate than radiography for the identification of apical dental pathology?

 

Clinical bottom line

Category of research question

Diagnosis

The number and type of study designs reviewed

The literature search identified four papers that were critically reviewed. The publications consist of two retrospective case-controlled studies, one clinical study and one descriptive study

Strength of evidence

Weak

Outcomes reported

Four studies reported the sensitivity of computed tomography (CT) for the diagnosis of apical dental pathology in horses presented for evaluation of clinical signs of sinus disease with histopathological evidence of apical dental pathology. All studies reported the radiographic changes present in these horses or used absence of definitive radiographic changes consistent with apical dental disease as a reason to undertake further CT evaluation. All four papers found that CT identified teeth with apical pathology that radiography had not

Conclusion

CT is more accurate than radiography for the diagnosis of equine maxillary apical dental pathology; however, clear guidelines on the CT changes associated with apical dental pathology are required. Loss of the lamina dura, infundibular changes or pulpal gas as singular findings on CT imaging can be seen in teeth with no underlying histopathological evidence of apical disease, and in maxillary teeth imaged in horses without clinical signs of maxillary cheek tooth pathology

 

How to apply this evidence in practice

The application of evidence into practice should take into account multiple factors, not limited to: individual clinical expertise, patient’s circumstances and owners’ values, country, location or clinic where you work, the individual case in front of you, the availability of therapies and resources.

Knowledge Summaries are a resource to help reinforce or inform decision making. They do not override the responsibility or judgement of the practitioner to do what is best for the animal in their care.
Can Teachers' Job Satisfaction Be Ensured Despite Economic Inadequacies? The Impact of Positive Psychological Capital
Authors: Elcicek Zakir , Han Bunyamin , Yildiz Sabriye
Published: April 2022

This research examines the impact of teachers' positive psychological capital (PPC) on their job satisfaction (JS) levels. In the study, the relational survey model was used by conducting hierarchical regression analysis. The sample of the study consists of randomly selected 376 teachers in Batman, Turkey. The data were collected with the "Positive Psychological Capital Scale" and “Minnesota Job Satisfaction Scale (MSQ-Short form)”. According to the results, the PPC levels (total scores and dimensions) of the teachers are at a very high level; only the optimism dimension of the PPC scale and JS were found to be at a high level. In the regression analysis, the model (Model 6) that measures the effect of all dimensions of PPC on JS is significant. This finding implies that PPC is a significant predictor on JS and approximately 22% of the total variance in job satisfaction is explained PPC. The results of the study imply that self-efficacy and optimism components of PPC can be used to increase JS of teachers even the economic needs are not adequately met.
Investigation of Primary School Children’s Views of Life During the COVID-19 Pandemic Through Metaphors
Authors: Taneri Ahu , Mutlu Dilek
Published: April 2022

Global epidemics bring about problems that affect the lives of all individuals to a great extent. Although there have been global epidemics at different times, especially in the last two decades, primary school students are faced with such a situation for the first time. In order for students to manage this process in a healthy manner, it is important to see life through their eyes. It is necessary for both decision makers and practitioners to refer to students’ own comments and statements in order to see the traces of the effects of the measures taken on behalf of the students on their views. Determining primary school students’ views of the concept of life in this process is extremely important in terms of seeing and interpreting the process from their perspective and planning the continuation of the process. In the current study, the metaphors that primary school students developed regarding the concept of life during the pandemic and the explanations they brought to these metaphors were examined. In the study, it was determined that the students were able to explain the concept of life in the COVID-19 period using different metaphors and qualifiers. It was seen that metaphors were gathered under the categories of being restricted, disruption of order, feeling threatened, and despair. It was concluded that primary school students evaluate life predominantly negatively during the COVID-19 period.
SURİYELİ ÖĞRENCİLERİN MATEMATİK DERSİ KAZANIMLARINA ULAŞMALARI SÜRECİNDE İKİNCİ SINIF ÖĞRETMENLERİNİN KARŞILAŞTIĞI SORUNLAR
Authors: DAĞLI Kadir , YÜKSEL Sedat
Published: April 2022

u araştırmanın amacı ilkokul ikinci sınıf öğretmenlerinin Suriyeli sığınmacı öğrencilere matematik kazanımlarını edindirme sürecinde karşılaştıkları zorlukları ortaya koymaktır. Nitel bir araştırma olan bu çalışmada temel nitel araştırma deseni kullanılmıştır. Araştırmanın çalışma grubunu Bursa'da Suriyeli sığınmacı öğrencilerin yoğun olarak bulunduğu okullarda görev yapan 13 öğretmen oluşturmuştur. Araştırmada veriler yarı yapılandırılmış görüşme ile toplanmış ve betimsel analiz ile çözümlenmiştir. Araştırmada öğretmenlerin Suriyeli sığınmacı öğrencilerin diğer derslere göre matematik dersini daha çok sevdikleri ve matematik dersinde daha başarılı oldukları görüşünde oldukları ortaya çıkmıştır. Öğretmenler matematik dersi kazanımlarına ilişkin olarak Suriyeli sığınmacı öğrencilerin genel olarak aritmetik ve geometrik kazanımlarda zorlanmazken akademik dil gerektiren problem çözme veri toplama kazanımlarına ulaşmada zorlandıkları görüşündedirler
Control tecnológico empresarial y nuevos problemas aplicativos tras la L.O. 3/2018. Una mirada desde el deber de información previa
Authors: García Rubio María Amparo
Published: April 2022

La aprobación de la L.O. 3/2018, de Protección de datos personales y garantía de los derechos digitales, ha puesto fin a la situación previa de ausencia de regulación legal específica en materia de control tecnológico en la relación laboral. No obstante, la llegada de esta Ley no ha acabado con todos los interrogantes que la cuestión plantea, no sólo por las dudas interpretativas que generan algunas de sus previsiones, sino también porque ahora es necesario determinar la relación entre ese nuevo parámetro de legalidad y el canon de constitucionalidad. Estas controversias se están haciendo visibles en la práctica judicial, de ahí que el presente estudio se dirija a profundizar en esos nuevos conflictos suscitados, con especial atención a los vinculados al deber empresarial de información.
Mechanisms of chemotherapy resistance in ovarian cancer
Authors: Ortiz Mylena , Wabel Emma , Mitchell Kerry , Horibata Sachi
Published: April 2022

Ovarian cancer is one of the most lethal gynecologic cancers. The standard therapy for ovarian cancer has been the same for the past two decades, a combination treatment of platinum with paclitaxel. Recently, the FDA approved three new therapeutic drugs, two poly (ADP-ribose) polymerase inhibitors (olaparib and niraparib) and one vascular endothelial growth factor inhibitor (bevacizumab) as maintenance therapies for ovarian cancer. In this review, we summarize the resistance mechanisms for conventional platinum-based chemotherapy and for the newly FDA-approved drugs.
Natural bioactive compounds: a potential therapeutic strategy to sensitize bladder cancer to cisplatin treatment?
Authors: Ruiz de Porras Vicenç
Published: April 2022

Bladder cancer (BC) is the tenth most common cancer, and its incidence is steadily rising worldwide, with the highest rates in developed countries. Neoadjuvant cisplatin-based chemotherapy followed by radical cystectomy is the standard therapy for patients with muscle-invasive bladder cancer. However, less than 50% of patients initially respond to this treatment and nearly all of them eventually develop resistance, which is an important barrier to long-term survival. Therefore, there is an urgent need to understand the mechanisms of cisplatin resistance in BC and develop ways to counteract them. Several preclinical studies have demonstrated that naturally derived bioactive compounds, such as phytochemicals and flavonoids, can enhance the antitumor activity of cisplatin, with minimal side effects, by targeting different pathways involved in cisplatin sensitivity and resistance. However, their poor bioavailability has been one of the main problems for their successful introduction into clinical practice. At present, however, many new formulations with greatly increased bioavailability are under study in several clinical trials with encouraging results.
Towards a BETter understanding of cardiac fibrosis
Authors: Stout Elizabeth S. , Elliott David A. , Porrello Enzo R.
Published: April 2022

Fibroblast activation is a hallmark feature of pathological remodeling of the heart and represents an attractive target for therapeutic intervention. Pharmacological inhibition of chromatin remodeling enzymes reduces cardiac fibrosis, but the underlying transcriptional regulatory mechanisms remain poorly understood. Using single-cell genomics to profile alterations in the transcriptional and chromatin landscape during stress-induced cardiac remodeling, Alexanian et al. discovered a critical role for Mesenchyme Homeobox 1 in the regulation of myofibroblast activation and cardiac fibrosis. We briefly review these important findings and comment on the significance of their work.
How to determine KPIs in Multi-Annual Infrastructure Contract – Case Montenegro
Authors:   University of Belgrade - Faculty of Transport and Traffic Engineering, Bošković Branislav , Bugarinović Mirjana , Stojadinović1 Nikola , Bankovic Milan
Published: April 2022

The transition to a contractual relationship between government and Infrastructure Manager under Directive 2012/34 /EU requires the possession of contract management skills and the development of key performance indicators (KPIs). Previous activities related to the Multi Annual Infrastructure Contract (MAIC) have been exclusively in the field of the Annual Infrastructure Maintenance Program implementation (railway maintenance, public procurement, and supervision of civil works implementation). However, under Directive 2012/34/EU it is necessary to introduce a system of performance indicators for upgrading/modernize infrastructure to obtain value for money. The paper presents a systematic approach in determining the KPIs and their merits on the example of a contract between the Government of Montenegro and the Railway Infrastructure manager of Montenegro (ŽICG JSC) with the aim to improve the operation and quality of services of ŽICG JSC and the condition of railway infrastructure in Montenegro as well. Keywords – Key performance indicators, railway infrastructure Multi-annual contract. Keywords – Key performance indicators, railway infrastructure Multi-annual contract.
Micromobility – Infrastructure, Legislative and Safety Challenges
Authors: Glavić Draženko , Trpković Ana , Jevremović Sreten , Milenković Marina
Published: April 2022

Abstract – Modern cities and their transportation systems are challenged by new mobility options – micromobility, which includes light vehicles such as electric: scooters, skateboards, bicycles etc. Regardless of whether they are private or public service offer, the micromobility opened many questions concerning legislation, infrastructure limitation and traffic safety, which will be briefly discussed in this paper. Keywords – Electric micromobility, Street redesign, Legislation, Safety, MaaS
Graph Database Modeling of Urban Area Road Networks
Authors: Hristoski1 Ilija , Malenkovska Todorova Marija
Published: April 2022

Abstract – Specific features delivered by the class of Graph Databases allow for modeling road networks of different scales. In this paper, we propose and implement a Graph Database model of a typical road network inherent to urban areas. Such a database can be used along with diverse information systems, to provide information of various natures. Keywords – Road networks, Urban areas, Traffic, Graph databases, Neo4j.
PSO contract management – achievements and challenges
Authors: Stanojević Miloš , Stanimirović Uroš , Bošković Branislav , Bugarinović Mirjana
Published: April 2022

Abstract – Introducing competition in the railway passenger market is still a complex problem, especially with certain, insufficiently addressed aspects of PSO contract management. Considering this have a significant influence on the performance of the rail traffic, this paper reviews the practice in relevant EU countries and the Republic of Serbia in terms of PSO contract management. Keywords – PSO, contract management, passenger traffic.
Simulation Model of Belgrade Suburban Passenger Trains Service Using OpenTrack
Authors: Jeremić Dušan , Milosavljević Milan , Vujović Dušan
Published: April 2022

Abstract – In this paper, simulation models, created in the OpenTrack simulation tool, were used to compare the proposed timetable with a variant in which all trains from and Lazarevac would be extended to Belgrade Center. This paper aims to analyze the effects of the increasing number of trains on part of Belgrade railway junction from Resnik to Belgrade Center. The results have shown that the section from Dedinje junction to Resnik has more than enough capacity for the increased number of trains. Also, the simulation results show us that when the number of trains increases by 40%, BG trains can operate without or with acceptable delays. Keywords – railway, simulation, BG voz, OpenTrack.
The impact of trailer active safety system on improving the safety of transport of dangerous goods
Authors: Matijašević Momčilo , Sremac Siniša , Ilić Jugoslav
Published: April 2022

Abstract – The intense technological growth results in the increase of demands for mobility of dangerous goods, mostly carried on the roads. The regulations that define the Transport of Dangerous Goods, give special emphasis to the mandatory equipment that must be installed (electronic suspension and braking systems) as well as its mandatory control of technical correctness. The efficiency of the braking system as well as the vehicle suspension system significantly affects the length of the stopping distance when moving through populated areas, moving at night or in heavy traffic and is of great importance in relation to the overall traffic safety. Proper technical control of vehicles with built-in electronic systems, includes well-trained workers, quality diagnostic equipment and the necessary awareness of transport participants about the importance of technical correctness of vehicles. All these factors and the impact of correctness of the braking and suspension systems on the vehicle safety are analysed in this paper. Keywords – Technical requirements for vehicles, transport of dangerous goods, ADR.
Development of Marketing Positioning of the Pilotless Bus in the Russian Market
Authors: Gorokhova Anna , Efremov Andrey
Published: April 2022

Abstract – In paper technique of development of pilotless bus marketing positioning in the Russian market will be offered. The technique consists of 4 stages: a research in positioning; determination of key properties of pilotless bus, company, market; definition of the development directions of the pilotless bus; comparative assessment of positioning options. Keywords – Pilotless bus (unmanned bus), Positioning, Marketing, Consumer perception.
Night Road Safety Inspection
Authors: Nováček Jakub , Kohout Tomáš
Published: April 2022

Abstract – Europe has committed to reduce the number of serious road traffic accidents. This requires building a safe infrastructure. Safety inspections are used to measure and increase the road safety. To fulfil the stated goals, the safety inspection must also be carried out at night, when specific road defects are encountered. Keywords – Night Safety Inspection, Safety Defects, Road lighting, Traffic accidents.
Closing the Knowledge Gap: Horizontal Transfer of Mariner Transposons between Rhus Gall Aphids and Other Insects
Authors: Ahmad Aftab , Su Xu , Harris AJ , Ren Zhumei
Published: April 2022

Horizontal transfer of transposons (HTT) is an important source of genomic evolution in eukaryotes. The HTT dynamics is well characterized in eukaryotes including insects however, but there is a huge gap of knowledge about HTT regarding many eukaryotes’ species. In this study we analyzed the events of the HTT between Rhus gall aphids (Hemiptera) and other insects. We analyzed the Mariner-like transposable elements (MLEs) belongs to Rhus gall aphids for the possible HT events. The MLEs have patchy distribution and have high similarity over the entire length of element with insects MLEs from different orders. We selected representative sequences from the Rhus gall MLEs and identified five events of HT between MLEs of Rhus gall aphids and other insects from five different orders. We also found multiple HTT events among the MLEs of insects from the five orders which demonstrate that these Mariner elements have been involved in recurrent HT between these six order of insects. Our current study closed the knowledge gap of HTT and reported the events between Rhus gall aphids and other insects for the first time. We believe that this study about HTT events will help to understand the evolution and spread of transposable elements in the genomes of Rhus gall aphids.
Genetic Diversity of Porcine Circovirus 2 Subtypes in Wild Boar and Domestic Pigs in Ukraine
Authors: Rudova Nataliia , Buttler Jeremy , Kovalenko Ganna , Sushko Mykola , Bolotin Vitaliy , Muzykina Larysa , Zinenko Oleksandr , Stegniy Borys , Dunaiev Yurii , Sytiuk Mykola , Gerilovych Anton , Drown Devin M. , Bortz Eric , Solodiankin Oleksii
Published: April 2022

Porcine circovirus type 2 (PCV2) is responsible for a number of porcine circovirus associated diseases (PCAD) that can severely impact domestic pig herds. For a non-enveloped virus with a small genome (1.7 kb ssDNA), PCV2 is remarkably diverse, with 8 subtypes (a-h). New subtypes of PCV2 can spread through migration of wild boars, which are thought to infect domestic pigs and spread further through the domestic pig trade. Despite a large swine population, the diversity of PCV2 subtypes in Ukraine has been undersampled, with few PCV2 genome sequences reported in the past decade. To gain a deeper understanding of PCV2 subtype diversity in Ukraine, samples of blood serum were collected from wild boars (n = 107) that were hunted in Ukraine during the November-December 2012 hunting season. We found 34/107 (31.8%) prevalence of PCV2 by diagnostic PCR. For domestic pigs, liver samples (n = 16) were collected from a commercial market near Kharkiv in 2019, of which 6/16 (37%) were positive for PCV2. We sequenced the genotyping locus ORF2, a gene encoding the PCV2 viral capsid (Cp), for 11 wild boar and 6 domestic pig samples in Ukraine using an Oxford Nanopore MinION device. Of 17 samples with resolved subtypes, PCV2 subtype b was most common in wild boar (10/11, 91%), while domestic pigs were infected with subtypes b and d. We also detected subtype b/d and b/a co-infections in wild boar and domestic pigs, respectively, and subtype f in a wild boar from Poltava for the first time in Ukraine. Building a maximum likelihood phylogeny, we identified a sublineage of PCV2 subtype b infections in both wild and domestic swine, suggesting a possible epizootic cluster and ecological interaction in northeastern Ukraine.
Activity-Dependent Induction of Younger Molecular, Cellular and Organism Phenotypes
Authors: Lissek Thomas
Published: April 2022

In several mammalian species including humans, complex stimulation patterns such as cognitive challenge and physical exercise lead to improvements in organ function, organism health and performance, as well as possibly longer lifespans. The hypothesis is presented here that activity-dependent transcriptional programs, induced by these environmental stimuli, temporarily and lightly de-differentiate somatic cells such as neurons and muscle cells into a state that resembles functionally younger cells to allow cellular remodeling and adaptation of the organism to environmental change. This cellular adaptation program targets several process classes that are heavily implicated in aging, such as mitochondrial metabolism, cell-cell communication, intracellular signaling and epigenetic information processing and leads to functional improvements in these areas. I reverse engineer these activity-dependent gene programs, identify critical molecular nexus points such as CREB, MEF2 and cFos and speculate as to how one might leverage them to prevent and attenuate human aging-related decline of body function, enhance human performance and restore more youthful levels of function and morphology. The findings presented here can serve as a basis for the study and development of effective longevity efforts as the underlying gene programs could be used as markers for treatment success and as targets for therapy development.
Automated Coronary Optical Coherence Tomography Feature Extraction with Application to Three-Dimensional Reconstruction
Authors: Carpenter Harry J. , Ghayesh Mergen H. , Zander Anthony C. , Di Giovanni Giuseppe , Li Jiawen , Psaltis Peter J.
Published: April 2022

Coronary optical coherence tomography (OCT) is an intravascular, near-infrared light-based imaging modality capable of reaching axial resolutions of 10-20 µm. This resolution allows for accurate determination of high-risk plaque features, such as thin cap fibroatheroma; however, visualisation of morphological features alone still provides unreliable positive predictive capability for plaque progression or future major adverse cardiovascular events (MACE). Biomechanical simulation could assist in this prediction, but this requires extracting morphological features from intravascular imaging to construct accurate three-dimensional simulations of patients’ arteries. Extracting these features is a laborious process, often carried out manually by trained experts. To address this challenge, numerous techniques have emerged to automate these processes while simultaneously overcoming difficulties associated with OCT imaging, such as its limited penetration depth. This systematic review summarises advances in automated segmentation techniques from the past five years (2016-2021) with a focus on their application to the three-dimensional reconstruction of vessels and their subsequent simulation. We discuss four categories based on the feature being processed, namely: coronary lumen; plaque characteristics and subtypes; artery layers; and stents. Areas for future innovation are also discussed as well as their potential for future translation.
Modeling of forest fires based on the Bayesian forecast model and geoinformation technologies
Authors: Barabash Oleg , Bandurka Olena
Published: April 2022

Today, a variety of information about forest ecosystems can be obtained using remote sensing methods. The use of space data for forest monitoring is cost-effective because it allows you to quickly obtain the objective information needed by foresters to solve practical problems. Satellite data provide wide coverage of forest lands, high accuracy of results, as well as high frequency of data obtained. Space images of the Ovruch district of the Zhytomyr region of Ukraine in the summer of 2020 were selected for the study. Determination of breed composition was carried out by the methods of controlled classification, namely the Bayesian classifier. It was found that 70 % of forests are pine, less aspen, hornbeam, birch, alder and ash tree species. According to statistics, during 2000-2020, 51.4 thousand hectares of forest plantations in Ukraine were damaged and destroyed by forest fires. Therefore, objective and timely information on the consequences of fires is needed to solve a wide range of applied problems of forestry. An important task in assessing the environmental and economic damage caused to forestry as a result of forest fires is to determine the area of damaged forests. The paper considers technologies for determining the area of the forest where the fire took place, using space images of the Landsat 8 satellite. The normalized NBR fire index before and after the fire and the DNBR index are used to identify areas burned by fire and impression levels. To predict forest fires, a mathematical model based on Bayes' theorem was created and a thematic map with fire hazard classes on a quarterly basis was created. To check the accuracy of the results of the created forecast model, the thematic map was combined with a layer of defined fire areas. This software product is quite flexible and versatile, it can be easily adapted for use not only to identify burned forest lands, but also for other areas.
Determination of higher harmonics source in mixed-load power supply systems
Authors: Gapon Dmytro , Zuev Andrey , Kachanov Petro , Kubrik Boris
Published: April 2022

The article considers the possibility of determining the source of higher harmonics of currents and voltages in the electrical network in the directions of power of the respective components. The research purpose is evaluating the effectiveness of theoretical methods, computer modeling of a fragment of the electrical network and electrical load receivers operating in parallel. Different combinations of active, reactive and nonlinear loading are investigated. Larionov's scheme was used as a nonlinear load. According to the results of the study, conclusions were made about the effectiveness of the method used. Thus, in particular, in the case of parallel operation of nonlinear and mixed active-nonlinear load, the source of higher harmonics is determined incorrectly. Suggestions for ways to improve the algorithm are made.
Outcomes Following Total Hip Arthroplasty for Osteonecrosis of the Femoral Head in Patients on Hemodialysis
Authors: Hoggard Timothy M. , Chen Dennis Q. , Quinlan Nicole D. , Bell Joshua E. , Werner Brian C. , Cui Quanjun
Published: April 2022

Background:

Osteonecrosis of the femoral head (ONFH) is a potentially debilitating condition, often requiring total hip arthroplasty (THA). Patients on hemodialysis (HD) are at increased risk for complications after THA for osteoarthritis, however there is limited information on outcomes of THA for ONFH in patients on HD. With increasing prevalence of chronic kidney disease (CKD) requiring HD, studies are needed to characterize the risk of complications in these patients. Therefore, the purpose of this study was to evaluate HD as a potential risk factor for complication after THA in patients with ONFH on HD.

Methods:

Patients on HD with ONFH who underwent THA with at least 2 years of follow-up were identified using a combination of ICD-9 and CPT codes in a national insurance database. A 10:1 matched control cohort of patients with ONFH not on HD was created for comparison. A logistic regression analysis was used to evaluate rates of death, hospital readmission, emergency room (ER) visit, infection, revision, and dislocation between cohorts. Differences in hospital charges, reimbursement, and length of stay between the two groups were also assessed.

Results:

One thousand one hundred thirty-seven patients on HD who underwent THA for ONFH were compared to a matched control cohort of 11,182 non-HD patients who underwent THA for ONFH. Patients on HD experienced higher rates of death (HD 4.1%, non-HD 0.9%; odds ratio [OR] 3.35, p < 0.01), hospital readmission (HD 16.1%, non-HD 5.9%; OR 2.69, p < 0.01) and ER visit (HD 10.4%, non-HD 7.4% OR 1.5, p < 0.01). Hemodialysis was not associated with higher risk of infection, revision, or dislocation, but was associated with significantly higher charges (p < 0.01), reimbursement (p < 0.01), and hospital length of stay (p < 0.01).

Conclusions:

While patients on HD do not have increased risk of implant-related complications, they are at increased risk of developing medical complications following THA for ONFH and subsequently may require more resources. Orthopedic surgeons and nephrologists should be cognizant of the increased risk in this population to provide appropriate preoperative counseling and enhanced perioperative medical management.

Level of Evidence:

Therapeutic Level III.