bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparative Analysis of Actual Cost and INA CBG Rate in Diabetic Gangrene Inpatients
Authors: Kinanti Diajeng Putri , Athiyah Umi , Nita Yunita , Diansyah Muhammad Noor
Published: December 2021

Background: Diabetic gangrene is a complication of diabetes mellitus that imposes a substantial financial burden on patients and their families as well as the health care system. Objective: To determine the total cost of disease, and the difference between real cost and INA CBG rate for diabetic gangrene inpatients from January - December 2017 at Universitas Airlangga Hospital, Surabaya Methods: The study was conducted retrospectively by using a total sampling method. The perspective used was the hospital perspective. This study's direct medical costs were laboratory, drug and consumable medical device costs, medical equipment rental, radiology examination, red cross, oxygen, service, and room costs. Data analysis was performed using an independent samples t-test. Results: The results showed that 148 patients met the inclusion criteria. The total real cost of diabetic gangrene inpatients at Universitas Airlangga Hospital in 2017 was IDR 1,339,949,381, and the total INA CBG rate for inpatients with diabetic gangrene was IDR 1,365,047,500. The difference was (p = 0.000) between real cost and INA CBG rate. Conclusion: There is a difference between the actual cost and the INA CBG rate for diabetic gangrene inpatients.
Linguistic Validation of Indonesian Version of the Audit of Diabetes-Dependent Quality of Life Questionnaire
Authors: Rooswita Putri Amelia , Nita Yunita , Zairina Elida , Nugraheni Gesnita , Libriansyah Libriansyah
Published: December 2021

Background: One of the impacts experienced by diabetes mellitus patients is a decrease in their quality of life. The Audit of Diabetes-Dependent Quality of Life (ADDQoL) is a widely used individualized diabetes-specific quality of life measure. However, there was no version available in the Indonesian language. Objective: This study is aimed to undertake linguistic validation, including a cultural adaptation of the ADDQoL questionnaire into the Indonesian language. Method: The original developer granted permission to use and modify the questionnaire. The international linguistic validation procedure developed by the Mapi Research Institute was used. There were six steps involved: forward translation, reconciliation, back translation, expert panel review by a psychologist and clinician, cognitive debriefing with diabetes patients, and proofreading. Result: Problems that arose during the linguistic validation process were resolved by finding conceptually equivalent alternatives and changing sentence structures to achieve equivalence in language, concept, and culture with the original version of the ADDQoL. The developer's team reviewed and discussed all actions taken. Cognitive debriefing interviews with five respondents showed that the ADDQoL questionnaire was simple to understand. Conclusion: The Indonesian version of the ADDQoL is linguistically and culturally validated. Further studies are needed to confirm the structure and reliability of the Indonesian ADDQoL.
Pemanfaatan Media Sosial (Twitter) sebagai Sarana Informasi bagi Mahasiswa di Perpustakaan Universitas Airlangga Surabaya
Authors: . Turwulandari
Published: December 2021

Informasi menjadi suatu hal yang sangat penting di era ini. Perpustakaan Universitas Airlangga sebagai penyedia informasi telah memanfaatkan media sosial berupa twitter. Twitter adalah media sosial yang memungkinkan untuk mengirimkan pesan hingga 140 karakter. Account Perpustakaan Universitas Airlangga adalah @unairlibrary telah di follow sebanyak 6568 follower,Perpustakaan Universitas Airlangga Surabaya telah mengakomodasi para penggunanya tentang kegiatan-kegiatan Perpustakaan Universitas Airlangga meliputi promosi perpustakaan, display produk-produk baru, acara-acara (talkshow, bedah buku, sharing session) serta saran dan kritik melalui media sosial.
Niat Mahasiwa di Surabaya untuk Berhenti Mengonsumsi Minuman Beralkohol Menggunakan Teori Attitude Towards Behavior
Authors: Sitio Denita Mayasari , Kevaladandra Zulfa , Nurmala Ira
Published: December 2021

ABSTRAKLatar Belakang: Minuman beralkohol dikaitkan dengan risiko bertambahnya masalah kesehatan seperti ketergantungan alkohol, sirosis hati, kanker dan cedera. Hubungan kausal terbaru oleh temuan penelitian adalah mengonsumsi alkohol mengakibatkan kejadian penyakit menular seperti tuberkulosis dan HIV/AIDS. Efek dari penggunaan alkohol adalah sekitar 3,3 juta kematian setiap tahun. Jadi, bahaya penggunaan alkohol menyumbang 5,9% dari semua kematian di seluruh dunia.Tujuan: Tujuan dari penelitian ini adalah untuk mendeskripsikan niat mahasiswa di Surabaya untuk berhenti mengonsumsi minuman beralkohol.Metode: Penelitian dilakukan mulai dari Oktober 2017 – Oktober 2018. Penelitian ini dilakukan dengan menggunakan metode penelitian kualitatif dengan pendekatan fenomenologi yang didukung dengan teknik in-depth interview. Informan dari penelitian ini terdiri dari dua kategori yaitu informan kunci dan informan. Adapun informan kunci adalah mahasiswa di Surabaya yang berusia 18-21 tahun, mengonsumsi minuman beralkohol dan memiliki keinginan untuk berhenti mengonsumsi minuman beralkohol. Sedangkan informan adalah teman dekat dari informan kunci. Jumlah informan penelitian adalah 18 orang. Informan dibagi menjadi 2 bagian, yaitu informan kunci dan informan. Informan kunci terdiri dari 7 orang, sedangkan informan terdiri dari 6 orang teman dekat informan kunci dan 5 orang pengurus yayasan ORBIT (Our Right To Be Independent) Surabaya. Pengambilan sampel penelitian menggunakan teknik snowball sampling yang dimulai dari informan kunci, kemudian informan kunci akan memberikan petunjuk untuk informan selanjutnya. Adapun analisis data dilakukan dengan melakukan pengambilan data hingga membuat kesimpulan.Hasil: Hasil penelitian menunjukkan bahwa sebagian besar informan mempercayai adanya dampak negatif akibat dari mengonsumsi minuman tersebut.Kesimpulan: Sebagian besar informan kunci memiliki attitude toward behavior (sikap terhadap perilaku) positif untuk berhenti mengonsumsi minuman beralkohol yang berasal dari evaluasi saat mengonsumsi minuman beralkohol dan mempercayai adanya dampak negatif akibat dari mengonsumsi minuman tersebut. Saran untuk peneliti lainnya diharapkan agar dapat mencari intervensi yang efektif dalam penanganan penyalahgunaan alkohol di kalangan remaja.Kata kunci: mahasiswa, minuman beralkohol, sikap
O Mal no mundo: uma breve abordagem filosófica com enfoque em Sto. Agostinho e Spinoza
Authors: Soares das Chagas José
Published: December 2021

A problemática clássica do mal na Filosofia. As atitudes teóricas diante da questão. As dificuldades enfrentadas no campo racional quando se apresenta Deus como causa de todas as coisas. Como Santo Agostinho (354-430) justifica a existência do mal a partir da noção de livre-arbítrio e da distinção daquele em ontológico, moral e físico. O confronto entre a concepção calvinista (agostiniana) de Blijenbergh e a de Spinoza (1632-1677) nas cartas do mal. A desantropomorfização de Deus e das noções de "bem" e "mal" na filosofia secularizada de Spinoza.
O confronto crítico de Arendt com Jaspers e Heidegger
Authors: Barbosa Kherlley Caxias Batista
Published: December 2021

A Filosofia Política de Arendt afunda raízes no pensamento existencial de Heidegger e Jaspers. Este trabalho tenta mostrar a apropriação crítica que Arendt faz dos seus mestres, salientando a aproximação e o distanciamento do pensamento arendtiano em relação à filosofia existencial na formação de sua original filosofia política.
Apresentação
Authors: Castelo Branco Judikael , Gomes Peixoto Erika
Published: December 2021

Apresentação do dossiê G. Agamben
Editorial
Authors: Abreu Cláudio
Published: December 2021

Editorial
Reducción y estructuralismo
Authors: O’Lery María de las Mercedes
Published: December 2021

El fenómeno de que una rama relativamente autónoma de la ciencia sea absorbida por, o “reducida” a, otra disciplina es innegable y es una característica recurrente de la historia de la ciencia moderna, y no hay razón para suponer que dicho fenómeno no continuará teniendo lugar en el futuro. Esto afirmaba Ernest Nagel hace exactamente setenta años en el intento por justificar la necesidad de esclarecer la reducción científica (NAGEL, 1949, p. 100). Incluso varios años antes reclamaba el que no se contara con un estudio cuidadoso de la naturaleza de la reducción ni siquiera por parte de aquellos cuya preocupación exclusiva era la lógica de la ciencia (NAGEL, 1935, p. 46). Los posteriores debates acerca de la noción de reducción en la ciencia estuvieron motivados especialmente a partir del modelo de reducción nageliano; el cual ha tenido tanto innumerables adherentes como variadas objeciones. Entre las respuestas inmediatas ante los problemas que adolecía este modelo clásico, puede contarse la ofrecida por el programa estructuralista como una de las primeras. En este trabajo se expondrá lo relativo a la noción de reducción en el marco del programa estructuralista. Una vez presentado este recorrido, se intentará un análisis ulterior acerca de la condición de reducción en sentido ontológico (MOULINES, 1984) tomando en cuenta uno de los más actuales refinamientos del marco conceptual estructuralista como lo es la noción de subestructura parcial escalonada.
Hacia una filosofía comprehensiva de las teorías científicas
Authors: Jaramillo Juan Manuel
Published: December 2021

El nacimiento de la filosofía de la ciencia profesional coincide con el desarrollo de la filosofía analítica y como ésta adopta el método del análisis lógico. Dicho análisis, en el caso de la filosofía de la ciencia, se circunscribe fundamentalmente a la elucidación lógica de la estructura interna de las teorías y de sus relaciones interteóricas inmediatas. Esta propuesta tuvo numerosas críticas, que llevaron a una nueva arquitectónica para la ciencia: la del estructuralismo metateórico. En ella se propone la reconstrucción axiomática de las teorías haciéndose uso de la teoría de informal conjuntos y se introduce los aportes histórico-pragmáticos del historicismo en el contexto de una semántica informal. La introducción de la noción de holón teórico pretende ofrecer una visión más comprehensiva de las teorías científicas. Se busca pasar del análisis local de las teorías y de su entorno inmediato, donde se privilegia la relación lógica de deducibilidad, a una síntesis más global, que correspondería a la estructura global de las teorías. En este trabajo son examinadas las implicaciones que tal propuesta metateórica tiene para una filosofía sintética de la ciencia, cuando las teorías se examinan dentro de una macro-unidad como la del holón teórico. Para ello, son examinadas las nociones interteóricas de reducción aproximativa y de presuposición en algunas teorías científicas.

El nacimiento de la filosofía de la ciencia profesional coincide con el desarrollo de la filosofía analítica y como ésta adopta el método del análisis lógico. Dicho análisis, en el caso de la filosofía de la ciencia, se circunscribe fundamentalmente a la elucidación lógica de la estructura interna de las teorías y de sus relaciones interteóricas inmediatas. Esta propuesta tuvo numerosas críticas, que llevaron a una nueva arquitectónica para la ciencia: la del estructuralismo metateórico. En ella se propone la reconstrucción axiomática de las teorías haciéndose uso de la teoría de informal conjuntos y se introduce los aportes histórico-pragmáticos del historicismo en el contexto de una semántica informal. La introducción de la noción de holón teórico pretende ofrecer una visión más comprehensiva de las teorías científicas. Se busca pasar del análisis local de las teorías y de su entorno inmediato, donde se privilegia la relación lógica de deducibilidad, a una síntesis más global, que correspondería a la estructura global de las teorías. En este trabajo son examinadas las implicaciones que tal propuesta metateórica tiene para una filosofía sintética de la ciencia, cuando las teorías se examinan dentro de una macro-unidad como la del holón teórico. Para ello, son examinadas las nociones interteóricas de reducción aproximativa y de presuposición en algunas teorías científicas.
Editorial
Authors: Santana Juliana , Duarte Fábio , Inocêncio Mattos Elizângela , Castilho Souza Raquel , Antonio Penedo do Amaral Roberto
Published: December 2021

Editorial Revista Perspectivas volume 4, número 2 (2019).
Editorial
Authors: Perspectivas Equipe
Published: December 2021

Editorial Perspectivas - Volume 5, número 1 - 2020
A PRÉ-HISTÓRIA DO RIO GRANDE DO NORTE
Authors: Nogueira Mônica
Published: December 2021

A Pré-História do Rio Grande do Norte, publicado pela Editora Brazil Publishing no ano de 2020 apresenta um panorama das pesquisas arqueológicas realizadas pelo Professor Valdeci dos Santos Júnior ao longo dos últimos 15 anos em todo o estado do Rio Grande do Norte, com especial foco na região Central Potiguar.
HISTÓRIA VISUAL DA ARQUEOLOGIA NO SERIDÓ
Authors: Nogueira Mônica , Mafra Fabio
Published: December 2021

A fotografia é um dos mais importantes registros realizados durante uma escavação arqueológica. Para além de auxiliar no controle das escavações e dos vestígios identificados, o registro fotográfico guarda memórias, e nos conta histórias. Na década de 1980, as arqueólogas Gabriela Martin e Alice Aguiar, acompanhadas de alunos do Curso de História da Universidade Federal de Pernambuco, iniciaram as pesquisas em Arqueologia no Seridó potiguar, nos municípios de Parelhas e Carnaúba dos Dantas – RN. A descoberta do manuscrito de José de Azevêdo Dantas forneceu informações inéditas sobre a presença de grafismos rupestres na região, similares àqueles registrados em São Raimundo Nonato – PI, pela arqueóloga Niède Guidon. Neste álbum, apresentam-se imagens deste período inicial das investigações. Todas as fotografias integram o banco de dados imagéticos da Fundação Seridó e INAPAS, selecionadas pelos autores apenas para compor a presente coleção. VISUAL HISTORY OF ARCHEOLOGY IN SERIDÓ  ABSTRACTPhotography is one of the most important records made during an archaeological excavation. In addition to assisting in the control of excavations and identified traces, the photographic record holds memories, and tells us stories. In the 1980s, archaeologists Gabriela Martin and Alice Aguiar, accompanied by students from the Federal University of Pernambuco, began archaeological research at Seridó potiguar, in Parelhas and Carnaúba dos Dantas - RN. The discovery of the José de Azevêdo Dantas manuscript provided unprecedented information about the presence of rock art in the region, similar to those recorded in São Raimundo Nonato - PI, by the archaeologist Niède Guidon. The images of this initial period of investigations are presented. All photographs are part of the Seridó Foundation and INAPAS imagery database, selected by the authors only to compose this collection.Keywords: Archaeology in Seridó; photographic records; archaeological excavation.
Decision Making Power of Homemakers in a Rural Muslim Community of West Bengal: An Empirical Study
Authors: Samsunnehar  , Sarkar Sumana
Published: December 2021

Decision-making power is a vital key for assessing the empowerment of a person. Empowerment increases self-efficacy by which one can control one’s mode of life for survival in a better way. It is an established fact that women are the most disempowered section in our society and the rural Muslim women are relatively more oppressed than others as there is the predominance of social-cultural and economic inequality among this minority community. As a result, these women have very limited opportunities to participate in the decision-making process related to their family matters and societal affairs linked with their own lives. Considering this scenario, the present study attempts to examine and analyse the decision-making power of homemakers in rural Muslim communities at micro level, taking Santoshpur village of Murshidabad district, West Bengal, as a case study. The methodology designed for the present study integrates both quantitative and qualitative methods based on field surveys. For this, fifty respondents have been selected using stratified purposive random sampling technique, and data have been acquired through face-to-face interviews through a semi-structured questionnaire. Then, the Cumulative Empowerment Index (CEI) is constructed based on selected eight key indicators to measure respondents' decision-making ability and liberty. Multiple Correlations are also computed, indicating that education and economic dependencies are the most critical determinants influencing women's empowerment and decision-making processes. The study also reveals that the existing rigid cultural system is mainly responsible for the suppression of women’s identity as well as their thoughts. But there remains hope for the next-generation girl children as different schemes are being taken up by the Government of West Bengal to promote and popularise women’s education at different levels.
Conformational Models of APP Processing by Gamma Secretase Based on Analysis of Pathogenic Mutations
Authors: Kim Meewhi , Bezprozvanny Ilya
Published: December 2021

Proteolytic processing of amyloid precursor protein (APP) plays a critical role in pathogenesis of Azheimer’s disease (AD). Sequential cleavage of APP by β and γ secretases leads to generation of Aβ40 (non-amyloidogenic) and Aβ42 (amyloidogenic) peptides. Presenilin-1 (PS1) or presenilin-2 (PS2) pay a role of catalytic subunit of γ-secretase. Multiple familial AD (FAD) mutations in APP, PS1, or PS2 result in increased Aβ42:Aβ40 ratio and accumulation of toxic Aβ42 oligomers and plaques in patient brains. In this study we performed molecular modeling of APP complex with γ-secretase and analyzed potential effects of FAD mutations in APP and PS1. We noticed that all FAD mutations in APP transmembrane domain are predicted to cause an increase in the local disorder of its secondary structure. Based on structural analysis of known γ-secretase structures we proposed that APP can form a complex with γ-secretase in 2 potential conformations – M1 and M2. In conformation M1 transmembrane domain of APP forms a contact with perimembrane domain that follows the transmembrane domain 6 (TM6) in PS1 structure. In conformation M2 transmembrane domain of APP forms a contact with transmembrane domain 7 (TM7) in PS1 structure. By analyzing effects of PS1-FAD mutations on local protein disorder index, we discovered that these mutations increase conformational flexibility of M2 and reduce conformational flexibility of M1. Based on these results we proposed that M2 conformation, but not M1 conformation, of γ secretase complex with APP leads to amyloidogenic (Aβ42-generating) processing of APP. Our model predicts that APP processing in M1 conformation is favored by a curved membranes, such as membranes of early endosomes. In contrast, APP processing in M2 conformation is likely to be favored by a relatively flat memranes such as membranes of late endosomes and plasma membrane. These predictions are consistent with published biochemical analysis of APP processing at different subcellular locations. Our results suggest that specific inhibitors of Aβ42 production could be potentially developed by selectively targeting M2 conformation of γ secretase complex with APP.
An Exploratory Investigation of Organic Solid Waste for Energy Use in the Dominican Republic: Case of the Municipality of Puñal, Santiago
Authors: Franco Edian F , Padrón Iglesia Wilfredo , Pérez Teruel Karina
Published: December 2021

One of the biggest problems that the Dominican Republic has had in recent decades is the efficient management of solid waste produced by the population. This problem has worsened in recent years due to the decrease in available areas for the construction of sanitary landfills, the lack of recycling culture in the population, the deficiency in waste collection, and the scarce legal controls aimed at preserving water and air and soil, among other factors. The objective of this study was to explore the management of solid waste by the population and the municipality of Puñal, province of Santiago, to evaluate and analyze the situation and generation of solid waste, municipal solid waste management services, and the attitudes of the population regarding recycling projects and waste management, to evaluate the viability and sustainability of the use organic waste for energy generation. A total of 275 households from 29 localities in the municipality of Puñal were surveyed, which allowed for a significant population sample. According to the results obtained, the most significant type of waste produced by families is organic waste, followed by plastic waste and paper. Of the total organic waste produced in the municipality, 53% of solid waste is disregarded through the municipal waste collection system, while 47% is used as plant fertilizers or animal feed. On the other hand, most households receive the municipal waste collection service and pay for this service. The results of our research show that the implementation of an energy production system based on organic waste would be viable in the municipality of Puñal. However, a more efficient waste collection system would be necessary and the development of programs and projects that allow all households to participate in the system.
Modeling and Numerical Simulation of a Vegetation Cover
Authors: Hidalgo Arturo , Tello Lourdes
Published: December 2021

The aim of this work is to introduce a mathematical model representing the evolution of the temperature in a vegetation cover and the ground underneath it. Vegetation, and its interaction with soil, plays a very important role in the protection of soil surface from the action of sun and precipitations. A reduction in the vegetated mass increase the risk of desertification, soil erosion or surface runoffs which which can give rise to soil loss and sediment retention. These processes can favour climate change and global warming, which are major concerns nowadays. The mathematical model presented takes into account the main processes involved in vegetation cover and the interaction with the soil, among which, we can mention the Leaf Area Index, which is a dimensionless quantity defined as the one-sided green leaf area per unit ground surface area, or albedo and co-albedo which are clearly influenced by the vegetation. It is also considered a nonlinear heat capacity in the soil which incorporates the latent heat of fusion, when the phase change takes place. The numerical technique used to solve the mathematical model is based on a finite volume scheme with Weighted Essentially Non Oscillatory technique for spatial reconstruction and the third order Runge-Kutta Total Variation Diminishing numerical scheme is used for time integration. Some numerical examples are solved to obtain the distribution of temperature both in the vegetation cover and the soil.
Typical 2-Cys Peroxiredoxins as a Defense Mechanism against Metal-Induced Oxidative Stress in the Solitary Ascidian Ciona robusta
Authors: Drago Laura , Ferro Diana , Bakiu Rigers , Ballarin Loriano , Santovito Gianfranco
Published: December 2021

Typical 2-Cys peroxiredoxins (2-Cys Prdxs) are proteins with antioxidant properties belonging to the thioredoxin peroxidase family. With their peroxidase activity, they contribute to the homeostatic control of reactive oxygen species (ROS) and, therefore, participate in various physiological functions such as cell proliferation, differentiation, and apoptosis. Although Prdxs have been shown to be potential biomarkers for monitoring the aquatic environments, minimal scientific attention has been devoted to describing their molecular architecture and function in marine invertebrates. Our study aims to clarify the protective role against stress induced by exposure to metals (Cu, Zn, and Cd) of three Prdxs (Prdx2, Prdx3, and Prdx4) in the solitary ascidian Ciona robusta, an invertebrate chordate. Here we report a detailed pre- and post-translational regulation of the three Prdx isoforms. Data on intestinal mRNA expression, provided by qRT-PCR analyses, show a generalized increase for Prdx2, 3, and 4, which is correlated to metal accumulation. Furthermore, the increase in tissue enzyme activity observed after Zn exposure is slower than that observed with Cu and Cd. The obtained results increase our knowledge of the evolution of anti-stress proteins in invertebrates and emphasize the importance of the synthesis of Prdxs as an efficient way to face adverse environmental conditions.
Protection of Human Rights and Freedoms in the Administrative Proceedings of the European Union
Authors: Rastorhuiev Oleksandr , Makushev Petro , Pukhtetska Alla , Hridochkin Andriy , Smaznova Irina
Published: December 2021

Since there is a problem of forming a system of modern doctrinal knowledge on protection in administrative proceedings by individuals of their rights violated in public relations, the topic under research becomes relevant. The justice in national administrative cases requires qualitative improvement taking into account European experience. The purpose of the research is to form a uniform judicial enforcement in the field of public relations, establish the rule of law, and provide fair justice. The methodological basis of this study is a set of general scientific (dialectical, analysis, and synthesis), as well as special legal (historical, comparative law, consideration and interpretation of legal norms, formal-logical) methods of scientific knowledge. The practical significance of the obtained results is that the formulated theoretical provisions, proposals and recommendations can be used: in research to conduct further research on the problems of administrative proceedings in Ukraine, ways and means of effective protection of subjective rights of individuals; in law-making for further improvement in accordance with European principles of national legislation; in the law enforcement practice of judges of administrative courts of Ukraine for consideration and resolution of public law disputes, in the protection of their rights in administrative judicial specialization by citizens and legal entities.
El cáncer como castigo divino en «Doña Blanca de Navarra», de Francisco Navarro Villoslada (1847)
Authors: Muñoz de Morales Galiana Javier
Published: December 2021

Doña Blanca de Navarra, de Navarro Villoslada, narra el asesinato de la dama que da título a esta, a manos de su hermana Leonor, quien la envenena para poder quedar como legítima heredera al trono navarro. No obstante, la misma divinidad decide castigar tal fratricidio provocándole a la nueva monarca un tumor maligno que concluye a un mismo tiempo con su vida y su reinado. El presente artículo tiene como objetivo detallar la importancia del cáncer como efecto de la providencia en el conjunto de la novela, atendiendo sobre todo a la ideología reaccionaria y en extremo católica del autor, a quien, con relación a momentos de crisis política, recomendaba una confianza absoluta en la providencia, a quien le atribuía la capacidad de luchar siempre por el bando en teoría correcto mediante la implantación de enfermedades en los adversarios políticos que supuestamente las merecían.
La morfología de la enfermedad: variación de los cuerpos enfermos en la literatura hispanoamericana de las últimas décadas
Authors: Wu Yiyang
Published: December 2021

En este artículo se pretende hacer un breve recorrido de las transformaciones que ha experimentado la dimensión metafórica de la enfermedad en la literatura hispanoamericana de las últimas décadas. Se trata de ahondar en las diferentes implicaciones alegóricas que tiene la enfermedad durante las distintas etapas de la literatura hispanoamericana. Bajo el ambiente autoritario de la dictadura, los cuerpos enfermos de los subalternos remiten constantemente a las condiciones estigmatizadas de las minorías sociales. A lo largo de la transición democrática, los cuerpos enfermos obtienen una connotación más subversiva y una expansión desterritorializadora que traspasa el control biopolítico. En algunas novelas de los últimos años del siglo XXI, la enfermedad logra una trascendencia que va más allá de las disputas ideológicas y sirve como denominador común del ser, poniendo de manifiesto la tendencia a volver a las cualidades básicas de la humanidad en la literatura.
La enfermedad como vertebradora de la escritura en «Papá» de Federico Jeanmaire
Authors: Caño Rivera Claudia
Published: December 2021

En este artículo exploramos la relación entre literatura y enfermedad en la novela Papá (2003) del escritor argentino Federico Jeanmaire. Para ello, tras un estado de la cuestión que nos sirve como aproximamiento a la obra, dividimos nuestro análisis en tres bloques principales: las metáforas que rodean la enfermedad, el traslado de las metáforas y la literatura y su relación con la enfermedad. De este modo, nuestro objetivo es, en un primer lugar, analizar la retórica que rodea la enfermedad e investigar el posible traslado de estas metáforas a otros temas que aparecen en el libro, como la relación paterno filial. En segundo lugar, estudiamos la relación entre literatura y enfermedad y las distintas posiciones desde las que abordar la cuestión, centrándonos en la enfermedad como origen del hecho literario y en la escritura como forma de terapia.
Peptidylglycine α-Amidating Monooxygenase And Adrenomedullin Measurement In Cirrhosis Suggesting Cardiomyopathy
Authors: Goetze Jens P. , Voiosu Andrei , Wiese Signe , Schulte Janin , Kaufmann Paul , Bergmann Andreas , Bartels Emil D. , Møller Søren
Published: December 2021

Peptidylglycine α-amidating monooxygenase (PAM) is a processing enzyme involved in maturation of regulatory peptides. One product of PAM activity is adrenomedullin (bio-ADM), which regulates vascular tone and endothelial integrity. In this study, we examined PAM activity and bio-ADM concentrations in patients with various degrees of hepatic cirrhosis including the role of the liver in net release of the two markers. We enrolled 48 patients with cirrhosis and 16 control subjects: The patients were evenly distributed according to the Child-Turcotte classification. PAM activity was progressively increased in cirrhotic patients but without a net release across the liver, leg, or kidney. In contrast, bio-ADM concentrations were not only associated to severity of disease but also found to be directly released by the liver. Given the major expression of PAM in the heart, we propose that increased PAM activity in plasma from patients with cirrhosis may reflect cardiac involvement, e.g. cirrhotic cardiomyopathy.
Maternal Near Miss in Patients with Systemic Lupus Erythematosus
Authors: Silva Arlley Cleverson Belo , Sun Sue Yazaki , Campanharo Felipe Favorette , Morooka Letícia Tiemi , Cecatti José Guilherme , Mattar Rosiane
Published: December 2021

Introduction: Systemic lupus erythematosus (SLE) may cause irreversible organ damage. Pregnancy with coexisting SLE may have severe life-threatening risks. Severe maternal morbidities (SMM) include maternal death, maternal near miss (MNM), and potentially life-threatening conditions (PLTC). This study aimed to determine the prevalence of SMM in patients with SLE and analyze the parameters that contributed to cases of greater severity. Methods: This is a cross-sectional retrospective study from analysis of data retrieved from medical records of pregnant women with SLE treated at São Paulo Hospital , Brazil, from 2005 to 2015. The pregnant women were divided in control group without complications, group with PLTC, and group with MNM. Results: Out of 149 pregnancies, there were 14 cases of MNM (9.4%), 56 cases of PLTC (37.6%), and no maternal death. The maternal near miss rate was 112.9 per 1,000 live births. The majority of PLTC (83.9%) and MNM (92.9%) cases had preterm deliveries with statistically significant increased risk compared with control group [p=0.0042; OR (95% CI): 12.05 (1.5-96.6) for MNM group and p=0.0001; OR (95% CI): 4.84 (2.2-10.8) for PLTC group]. SMM increases the risk of longer hospitalization [p<0,0001; OR (95% CI): 18.8 (7.0-50.6) and p <0.0001; OR (95% CI): 158.17 (17.6-1424,2) for PLTC and MNM, respectively], newborns with low birth weight [p=0.0006; OR (95% CI): 3.67 (1.7-7.9) and p=0.0009; OR (95% CI): 17.68 (2-153.6) for PLTC and MNM group, respectively] as well as renal diseases [PLTC (58.9%, 33/56; p = 0.0069) and MNM (78.6%, 11/14; p = 0.0026)]. MNM cases presented increased risk for neonatal death [p=0.0128; OR (95% CI): 38.4 (3.3-440.3)], stillbirth and miscarriage [p=0.0011; OR (95% CI): 7.68 (2.2-26.3)]. Conclusion: SLE was significantly associated with severe maternal morbidity, longer hospitalizations, and increased risk of poor obstetric and neonatal outcomes, such as prematurity, neonatal death, miscarriage and fetal loss.
MAGNet: A Camouflage Object Detection Network Simulating The Observation Effect of Magnifier
Authors: Jiang Xinhao , Cai Wei , Jiang Bo , Yang Zhiyong , Wang Xin
Published: December 2021

In recent years, protecting important objects by simulating animal camouflage has been widely used in many fields. Therefore, the Camouflaged Object Detection (COD) technology has emerged. COD is more difficult than traditional target detection techniques because of the high degree of fusion of camouflaged objects with the background. In this paper, we strive to identify camouflaged objects more accurately. Inspired by humans using a magnifier to search for hidden objects in pictures, we propose a COD network that simulates the observation effect of a magnifier, termed Magnifier Network (MAGNet). Specifically, our MAGNet contains two parallel modules, i.e., Ergodic Magnify module (EMM) and Attention Focus module (AFM). The EMM is designed to mimic the magnifying process of a magnifier ergodicing an image, and the AFM is used to perform the observation process in which human attention is highly focused for focusing on a region. The two sets output camouflaged object maps are merged to achieve the effect of simulating the observation of the object by a magnifier. Extensive experiments demonstrate that compared with 14 cutting-edge detection models, the MAGNet can achieve the best comprehensive effect of 8 evaluation indicators on the public COD dataset, and the segmentation accuracy is significantly improved.
Rate of Postoperative Urinary Retention After Anterior Compartment Prolapse Surgery: a Randomized Controlled Trial Comparing Early Versus Conventional Transurethral Catheter Removal
Authors: Chansriniyom Nareenun , Kijmanawat Athasit , Wattanayingcharoenchai Rujira , Aimjirakul Komkrit , Bartlett Jittima Manonai , Chinthakanan Orawee
Published: December 2021

Purpose To compare the rate of postoperative urinary retention (POUR) after anterior prolapse surgery between early transurethral catheter removal (24 hours postoperatively) and our standard practice (on postoperative day 3)Methods We conducted a randomized controlled trial among patients undergoing anterior compartment prolapse surgery between 2020 and 2021 at a university hospital. Women were randomized into two groups. After removal, if the second void residual urine volume exceeded 150 mL, POUR was diagnosed and intermittent catheterization was performed. The primary outcome was the POUR rate. The secondary outcomes included urinary tract infection, asymptomatic bacteriuria (AB), time to ambulation, time to spontaneous voiding, length of hospitalization, and patient satisfaction.Results Sixty-eight women were enrolled. There were no significant differences in baseline characteristics, intraoperative blood loss, operative time, anesthetic modalities, opioid use, and complications. The overall POUR rate was 29.4%. The POUR rate in the conventional group was 18.2% higher than that in the early-removal group; however, this was not statistically significant. (32.4% vs. 26.5%, RR 0.82; 95% CI: 0.39–1.72). There was no significant difference between groups for postoperative AB rate (14.7 vs. 0%, p=0.053). The early-removal group had shorter lengths of hospital stay (1 day vs. 3 days, p<0.001) and 3.8 hours earlier time to ambulation (p=0.2), without significant differences in postoperative patient satisfaction. Conclusion Among patients undergoing anterior compartment prolapse surgery, early catheter removal was comparable in POUR rate to conventional treatment, with shorter hospitalization. Therefore, early transurethral catheter removal is preferable following anterior compartment prolapse surgery. Clinical trial registration number thaiclinicaltrials.org, TCTR20210309003, 09 March 2021, retrospectively registered.
Metabolic and Anti-Inflammatory Effects of Antidepressants in Patients Diagnosed with Major Depressive Disorder: A Prospective Cohort Study
Authors: Hussein Osamah , Izakson Lidia , Zidan Jamal
Published: December 2021

Introduction:
There is growing evidence showing a correlation between major depression disorder (MDD), metabolic syndrome and inflammation. To examine the influence of antidepressant medications on the metabolic, inflammatory profiles, oxidative stress and endothelial derangement of patients suffering from MDD.
Results
Depressive patients displayed significantly higher serum triglycerides than control group, which increased significantly during eight weeks of antidepressive treatment. In the patients' group, serum levels of ALT and AST increased significantly during treatment. Serum peroxide level was significantly higher in patients before and during treatment vs. controls and decreased significantly in the patients' group during treatment. Macrophage chemoattractant protein-1 and hs-CRP serum levels were higher in patients before treatment as compared with controls. The percentage of gated IgM CD19+ and CD14+ cells in depressive patients before treatment was significantly higher than in the control group. The percentage of T regulatory cells increased significantly during antidepressive treatment.
Discussion
MDD patients had increased oxidative stress, inflammatory responses, metabolic derangements and endothelial injury. Antidepressant medications increased the percentage of T regulatory cells.
Methods
Twenty-nine patients aged 22-58 who were diagnosed with MDD but not medicated, were selected for the study. During the 8-week duration of the research, patients received anti-depressant medication.
Synthesis of 2-methylacrylamide/high-molecular-weight Cellulose for Removing Anionic Dyes from Water by Irradiation with Gamma Rays
Authors: Zhang Shuaifeng , Gu Jun , Fan Baochao , Li Li , Li Bin
Published: December 2021

We report a new method for treating high-molecular-weight cellulose with 60Co gamma rays to simultaneously graft functional groups onto the natural polymer and promote its solubility. After exposing cellulose to a 40-kilogray dose of gamma rays in the presence of 2-methylacrylamide, numerous amide groups were grafted onto the cellulose chain and its solubility increased markedly. Amide-functionalized aerogels were prepared via the sol-gel method using the irradiated product as a raw material. Compared with 40-kGy-irradiated cellulose aerogel, the amide-functionalized aerogels had relatively high zero-point charge pH values and excellent adsorption capacities with regard to anionic dyes over the pH range 2-10. They were also stable in terms of reusability. Therefore, the 2-methylacrylamide/high-molecular-weight cellulose aerogel has great potential for use in the treatment of colored surface wastewater. The 60Co gamma ray irradiation technique described herein is a flexible, stable and highly efficient method for the preparation of functionalized cellulose products.
Treatment of Polycystic Ovary Syndrome-Related Infertility Using a Combination of Compound Xuanju Capsules and Hormone Therapy: A Meta-Analysis
Authors: Ma Qianwen , Tan Yong
Published: December 2021

Objective

To compare the therapeutic effects of compound Xuanju capsules combined with hormone therapy versus hormone therapy alone on polycystic ovary syndrome (PCOS)-related infertility using a meta-analysis.
Methods

Electronic databases including PubMed, The Cochrane Library, Web of science, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), Wanfang Data, and VIP database were manually searched. The quality of included studies was evaluated based on the Cochrane systematic review standards, and the valid data were extracted for meta-analysis using Revman 5.3 software.
Results

A total of 14 randomized controlled trials accounting for 1249 patients were included. Meta-analysis showed that patients in the compound Xuanju capsule + hormone therapy group had higher estradiol levels and overall rates of effective treatment than those in the hormone therapy alone group. Moreover, they also exhibited lower levels of luteinizing hormone and follicle-stimulating hormone as well as lower Kupperman scores than the hormone therapy alone group.
Conclusions

The combination of compound Xuanju capsules and hormone therapy is more effective than hormone therapy alone in the treatment of PCOS-related infertility. However, the quality of current studies is low, and high-quality clinical trials are warranted.
Childbirth Experience, Risk of PTSD and Obstetric and Neonatal Outcomes According to Antenatal Classes Attendance
Authors: Avignon Valerie , David Baud , Laurent Gaucher , Corinne Dupont , Antje Horsch
Published: December 2021

Antenatal classes have evolved considerably and include now a discussion of the parents' birth plan. Respecting this plan normally results in a better childbirth experience, an important protective factor of post-traumatic stress disorder following childbirth (PTSD-FC). Antenatal class attendance may thus be associated with lower PTSD-FC rates.This cross-sectional study took place at a Swiss University hospital. All primiparous women who gave birth to singleton from 2018-2020 were invited to answer self-reported questionnaires. Data for childbirth experience, symptoms of PTSD-FC, neonatal, and obstetrical outcomes were compared between women who attended (AC) or not (NAC) antenatal classes.A total of 794/2876 (27.6%) women completed the online questionnaire. Antenatal class attendance was associated with a poorer childbirth experience (p=0.03). When taking into account other significant predictors of childbirth experience, only induction of labor, use of forceps, emergency caesarean, and civil status remained in the final model of regression. Intrusion symptoms were more frequent in NAC group (M=1.63 versus M=1.11, p=0.02). Antenatal class attendance, forceps, emergency caesarean, and hospitalisation in NICU remained significant predictors of intrusions for PTSD-FC. Use of epidural, obstetrical, and neonatal outcomes were similar for AC and NAC.
DNA damage in tissue-resident macrophages leads to age-related neurodegeneration
Authors: garinis George , Gkirtzimanaki Katerina , Tsakani Edisona , Arvanitaki Ermioni , Nenedaki Electra , Kefalogianni Mary , Niotis Georgios , Kalafatakis Ilias , Goulielmaki Evi , Psilodimitrakopoulos Sotiris , Karagogeos Domna , Stratakis Emmanuel
Published: December 2021

Neurodegenerative disorders are a growing challenge for the elderly yet their etiology remains elusive. Here, we show that persistent DNA damage in tissue-resident macrophages carrying an ERCC1-XPF DNA repair defect leads to cerebellar ataxia in mice. We find that cytoplasmic chromatin fragments accumulate in the brain microglia of progeroid and naturally aged mice stimulating a type-I Interferon (IFN-I) response and are then packaged in extracellular vesicles (EVs) leading to Purkinje cell death and neurodegeneration in Er1CX/− animals. To reduce neuroinflammation, we developed an EV-based strategy to deliver recombinant DNase I specifically in inflamed Er1CX/− microglia in vivo. Our approach rapidly removes dsDNAs from the cytoplasm of microglial cells and in secreted EVs; it alleviates the IFN-I response, decreases Purkinje cell death and delays the onset of neuronal decline in Er1CX/− animals. Thus, brain microglia causally contribute to neurodegeneration allowing for the development of promising therapeutic strategies against age-related neuroinflammation.
Low-Stress Livestock Handling Protects Cattle in a Five-Predator Habitat
Authors: Louchouarn Naomi X , Treves Adrian
Published: December 2021

Given the ecological importance of top predators, societies are turning to non-lethal methods for coexistence. Coexistence is challenging when livestock are released within wild predator habitats, even when people supervise or use lethal methods. We report a randomized, controlled design to evaluate low-stress livestock handling (L-SLH), a form of range riding, to deter grizzly (brown) bears, gray wolves, cougars, black bears, and coyotes in Southwestern Alberta. The treatment condition was supervision by two newly hired and trained range riders and an L-SLH practicing range rider. This treatment was compared against a baseline pseudo-control condition of the single experienced range rider working alone. Cattle experienced zero injuries or deaths in either condition. We infer that inexperienced range riders trained and supervised by an experienced rider did not raise or lower the risk to cattle. Also, predators did not shift to the cattle herds protected by fewer range riders. Pending experimental evaluation of other designs, we recommend use of L-SLH.
Mercury and selenium concentrations in the oysters Saccostrea palmula and Crassostrea corteziensis from four coastal lagoons of NW Mexico: health risk assessment
Authors: Sepúlveda Carlos Humberto , Sotelo-Gonzalez Maria Isabel , Osuna-Martínez Carmen Cristina , García-Ulloa Manuel , Góngora-Gómez Andrés Martín , Frías-Espericueta Martín Gabriel , Sánchez-Cárdenas Rebeca , Espinosa-Alonso Laura Gabriela
Published: December 2021

Mercury (Hg) and selenium (Se) concentrations in the soft tissue of the oysters Saccostrea palmula and Crassostrea corteziensis from four coastal lagoons (Altata, Macapule, Navachiste, El Colorado) of Northwest Mexico were determined. A total of 2520 specimens of S. palmula and 3780 of C. corteziensis (72.15 ± 4.95 and 73.57 ± 5.31 mm, respectively) were sampled seasonally from summer 2019 to spring 2020. The higher Hg concentration (wet weight) for S. palmula (0.13 ± 0.03–0.11 ± 0.02 µg g−1) and C. corteziensis (0.12 ± 0.02–0.11 ± 0.03 µg g−1) were obtained in summer−autumn 2019; Hg level was similar among the coastal lagoons and did not exceed the limit established by Mexican legislation and by the Food and Drug Agency. The higher Se concentration occurred in spring 2020 for both oyster species in El Colorado lagoon (4.55 ± 0.02 and 4.08 ± 0.05 µg g−1, respectively). The Se/Hg molar ratio of S. palmula and C. corteziensis ranged from 48.76–149.59 and 31.72–155.37, respectively; while the Se health benefit value was 19.23–42.28 and 17.82–35.30, respectively. The hazard quotient for Hg -estimated as methylmercury- and Se in both species of oyster was below 1. The high molar ratio obtained (Se/Hg > 1) indicates that the concentration of Se was sufficient to neutralize the possible toxicity of the Hg, therefore, the consumption of S. palmula and C. corteziensis from the four coastal lagoons studied does not represent a risk.