bluuebunny/crossref_metadata_2025 huggingface dataset:
High dose rate brachytherapy – long term results
Authors:   Clinic of radiotherapy, National Oncology Hospital (USBALO), Sofia, Bulgaria, Genova Boryana , Parvanova Veselina ,   Clinic of radiotherapy, National Oncology Hospital (USBALO), Sofia, Bulgaria, Mihaylova Iglika ,   Clinic of radiotherapy, National Oncology Hospital (USBALO), Sofia, Bulgaria
Published: January 2023

Introduction and objective: High-dose-rate brachytherapy with a temporary implant is one of the alternative methods for the treatment of localised prostate carcinoma, along with radical prostatectomy and external beam radiation therapy. The objective of this study is to analyze the long-term treatment results after definitive high-dose-rate brachytherapy for localised prostate carcinoma in USBALO. Material and methods: For the period from January 2011 to January 2019, 90 patients were treated with HDR-brachytherapy (with a temporary implant) in the Radiotherapy Department of USBALO. The average age is 66.5 years (53÷78 years). Patients are divided into low risk group – 54 (60%) and intermediate risk due to the presence of 1 negative factor – 36 (40%) patients. Follow-up ranged from 16 to 129 months (mean 84 months or 7 years). For the area of ​​the prostate and the base of the seminal vesicles, 20 (22.2%) patients received 3 fractions of 10.5 Gy over 14 days, and 70 (77.8%) received a dose of 3 x 11 Gy. Results: During the follow-up period, biochemical control was established in 78 patients (86.7%). Five-year biochemical control for all patients was 90%, and the 10-year biochemical control – 86.7%. Long-term follow-up of patients shows 5- and 10-year biochemical progression-free survival of 87.9% and 79.7%, respectively. Conclusions: Definitive high-dose-rate brachytherapy provides excellent long-term outcomes in low-risk and favorable intermediate-risk patients with localised prostate cancer in our data compared with those reported to date.
Efficacy and safety of retrograde ureteroscopy for the treatment of impacted proximal ureteral stones larger than 10 mm
Authors:   Department of Urology and Nephrology, Military Medical Academy, Sofia, Hristov Konstantin , Petkova Kremena ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Petrova Daniela ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Petrov Petar ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Gatsev Ognyan ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Todorova Viktoria ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Saltirov Iliya
Published: January 2023

Introduction and objective: Optimal management of large impacted proximal ureteral stones remains controversial. Retrograde ureteroscopy in these cases may be challenging due to the presence of mucosal edema and inflammation, tortuousity and unusual angulations of the ureter. The objective of this study is to evaluate the efficacy and safety of retrograde ureteroscopy (URS) for the treatment of impacted proximal ureteral stones larger than 10 mm. Material and methods: A prospectively collected database of 143 patients, who underwent retrograde ureteroscopy for impacted proximal ureteral stones ≥ 10 mm between January 2016 and December 2021, was reviewed. Data on patients’ preoperative characteristics, stone-free rates, complications and auxiliary procedures was analyzed. Results: Patients’ mean age was 54.2±13.4 years, and male-to-female ratio – 67.8%/32.2%. Mean stone length was 14.2±5.4 mm and mean stone width – 9.6±2.9 mm. 26 (18.2%) patients were on preoperative anticoagulation therapy, which could not be discontinued. 26 patients (18.2%) had preoperative drainage with ureteral stent JJ, and 7 (4.9%) – with percutaneous nephrostomy. Stone-free rate after single procedure was 88.8%. Mean operative time was 44.2±15.4 min. There were no cases of failed endoscopic access to the stone. Flexible ureteroscopy was performed in 34 (23.8%) cases. Postoperative drainage was ureteral stent JJ in 71 (49.7%) patients and ureteral catheter for 24 h – in 33 (23.1%). Most common postoperative complications were fever in 5 (3.5%) and postoperative renal colic – in 5 (3.5%) patients. 8 patients (5.6%) underwent SWL for treatment of residual fragments and 2 (1.4%) – retrograde intrarenal surgery. Conclusions: The results from this study demonstrate that retrograde ureteroscopy is an effective and safe treatment modality for impacted proximal ureteral stones ≥ 10 mm. Its high stone-free rate and low complication rate make retrograde URS a suitable first-line treatment for anticoagulated patients with impacted proximal ureteral stones, who are at increased risk of complications from the antegrade approach
Impact of ureteral access sheath use on outcomes of flexible ureteroscopy for renal stones
Authors:   Department of Urology and Nephrology, Military Medical Academy, Sofia, Petkova Kremena , Petrov Petar ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Petrova Daniela ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Gatsev Ognyan ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Todorova Viktoria ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Hristov Konstantin ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Saltirov Iliya ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria
Published: January 2023

Introduction and objective: Improvements in endoscopic technologies have led to an expansion of flexible ureteroscopy indications in the treatment of renal and ureteral stones. Ureteral access sheath (UAS) was introduced in the clinical practice to facilitate endoscopic access into the upper urinary tract, reduce intrarenal pressure during the procedure and allow the extraction of fragments. The objective of this study is to analyze the impact of UAS on the efficacy and safety of flexible ureteroscopy (fURS) for the treatment of renal stones. Material and methods: a prospectively collected database including 251 consecutive patients treated with fURS between January 2018 and November 2022 was analyzed. Patients were divided into two groups: group 1 – without UAS, 21 patients (8.3%) and group 2 – with UAS, 231 patients (91.7%). UAS was used at the surgeon’s discretion and 3 patients (1.2%) underwent a sheathless procedure due to failure of UAS insertion. Data on patients’ preoperative characteristics and fURS efficacy and safety were compared. Results: There were no statistically significant differences in patients’ preoperative characteristics except for stone size and surface, which were significantly larger in group 2 (9.6±4.1 vs 13.8±5.2 mm; р<0.001 and 68.6±74.2 vs 128.3±109.3 mm2, p=0.002, respectively). Operating time was significantly longer in group 2 (33.6±12.9 vs 42.0±12.9 min, p=0.005). Stone-free rate after a single procedure and at 3rd postoperative month was similar between groups (95.2% vs 87%, p=0.486 and 95.2% vs 88.7%, p=0.709, respectively). The intra- and postoperative complication rates were higher for group 1 (4.8% vs 0.8%, р=0.011 and 14.3% vs 12.1%, p=0.062, respectively). Multivariate regression model identified stone surface (р<0.001), number of stones (p=0.005) and calcium oxalate monohydrate stone composition (р=0.005), but not UAS use (p=0.580), as independent predictors for stone-free rate following fURS. Conclusions: The results of this study suggest that UAS use has no impact on the efficacy of fURS and is not associated with an increased rate of intra- and postoperative complications.
Safety of the ureteral access sheath in unstented ureters
Authors:   Department of Urology and Nephrology, Military Medical Academy, Sofia, Petrova Petar , Todorova Viktoria ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Hristov Konstantin ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Petrova Daniela ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Gatsev Ognyan ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Petkova Kremena ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Saltirov Iliya ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria
Published: January 2023

Introduction and objective: With advances in technology in recent years, the indications for flexible ureterorenoscopy (fURS) for the treatment of upper urinary tract stones have expanded. To facilitate retrograde access to the kidney, extraction of fragments and reduction of intrarenal pressure during surgery, the ureteral access sheath (UAS) was introduced. The aim of the present study was to investigate the incidence of postoperative stricture after the use of UAS in unstented patients and the effectiveness and safety of different sizes of UAS. Material and methods: A retrospective study was performed, including 240 fURS procedures with the use of UAS, performed between January 2019 and April 2022. We excluded cases in which a previous intervention was performed, patients with a JJ stent, nephrostomy or impacted stones, patients who underwent radiation treatment, or had urinary tract malignancies. The postoperative stricture was considered the presence of hydronephrosis on ultrasound examination or on CT scan in the first and third months. A comparative analysis of the effectiveness and safety of using the 11/13 Fr UAS and the 12/14 Fr UAS was performed. Results: The cohort included 167 patients with a postoperative follow-up of 3 months. In 143 patients (85.7%) UAS 11/13 Fr was used, in 24 patients (14.3%) UAS 12/14 Fr. No postoperative stricture was found in any of the patients. There was no significant difference in efficacy after one procedure using UAS 11/13 versus UAS 12/14 (93.0% vs. 91.7%, p=0.684), despite the larger stone volume in UAS 12/14 (123.4±93.5 mm2 vs. 95.5±41.5, p=0.009). Mean operative time was significantly longer in UAS 11/13 (38.7±11.2 min vs 50.2±16.2 min; p=0.049). Larger UAS size was not associated with more complications compared to a smaller size, comparative safety analysis found no significant differences in the incidence of intra- and postoperative complications (0% vs. 0.7%, p=0.821 and 8.4% vs. 7.2% p=.705, respectively). Conclusions: The results of this study suggest that UAS use has no impact on the efficacy of fURS and is not associated with an increased rate of intra- and postoperative complications.
Treatment with SGLT-2 inhibitors and urinary tract and genital infections risk
Authors:   Department of Urology and Nephrology Military Medical Academy, Sofia, Bulgaria, Petrova Daniela
Published: January 2023

The kidneys are involved in the regulation of glucose homeostasis by reabsorbing glucose filtered into the glomerular filtrate. Reabsorption occurs in the proximal convoluted tubule and is carried out by two isoforms of the sodium-glucose cotransporters (SGLTs). SGLT-2 inhibitors suppress renal glucose reabsorption by lowering the renal threshold for glucose excretion by inhibiting SGLT-2 protein in the proximal tubule of the kidney. As a result, the excretion of glucose in the urine increases. SGLT-2 inhibitors have revolutionized the treatment of patients with type 2 diabetes mellitus with or without cardiovascular disease and patients with diabetic nephropathy. The mechanism of action, SGLT-2 inhibitors is associated with an increase in glycosuria, a risk factor for genital and urinary infections. Additional studies and monitoring of adverse side effects and complications of treatment with these medications are needed. The occurrence of mild to moderate genital and urinary tract infections can be treated according to good clinical practice guidelines for this type of disease, and the continuation of treatment should be determined individually for each patient.
Efficacy and safety of percutaneous nephrolithotomy in patients with body mass index over 30 kg/m2
Authors:   Department of Urology and Nephrology, Military Medical Academy, Sofia, Todorova Viktoria , Gatsev Ognyan ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Hristov Konstantin ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Petrov Petar ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Petrova Daniela ,   Department of Urology and Nephrology, Clinic of Endourology and SWL Military Medical Academy, Sofia, Petkova Kremena ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Saltirov Iliya ,   Department of Urology and Nephrology, Military Medical Academy, Sofia, Bulgaria
Published: January 2023

Introduction and objective: With the increasing prevalence of urolithiasis, the world is also witnessing an epidemic of obesity. Management of such patients is challenging due to the body habitus and the presence of multiple comorbidities. It is unclear whether percutaneous nephrolithotomy (PCNL) has similar efficacy and safety in obese patients as compared to patients with normal body mass index (BMI). The objective of this study is to assess the impact of body mass index on the efficacy and safety of PCNL in patients with BMI > 30 kg/m2. Material and methods: The medical records of 124 obese patients with BMI > 30 kg/m2, treated between January 2017 and September 2022 were retrospectively reviewed. All patients underwent standard PCNL with ultrasound probe disintegration of stones. Data on patients preoperative characteristics, stone free rates, operating times, intra- and postoperative complications were analysed. Results: Patients’ mean age was 57.0±9.2. The majority of patients had at least one comorbidity – 53 (43.4%) had diabetes, 45 (36.3%) – hypertension and 7 (5.6%) had ischemic heart disease. 100 (80.6%) patients had BMI between 30-34 kg/m2, 12 (9.7%) – between 35-39.9 kg/m2 and 12 (9.7%) patients had BMI measured over 40 kg/m2. Mean stone length was 40.0±14.9 mm and mean stone width 29.3±28.7 mm. In the majority of patients 118 (95.2%) lower pole puncture was performed for access to the stone. 54 (43.5%) of the patients had staghorn stones and 58 (46.8%) had stones composed of uric acid. Mean operative time was 50.3±12.2 min and mean hospital stay 3.5±0.9 days. Stone-free rate after a single procedure was 80.6%. Postoperative complications were fever in 5 (4%) patients, haematuria in 2 (1.6%), formation of AV fistula in 2 (1.6%) and renal colic – in 3 (2.4%) patients. Management of these complications included medical treatment in 7 (5.6%) patients, double JJ stent insertion in 4 (3.2%) and angioembolization in 2 (1.6%). Conclusions: PCNL is safe and effective procedure in obese patients with BMI > 30 kg/m2. BMI seems to have no impact the stone-free or complication rates, despite the potential difficulties in performing it in obese patients.
Obturator hernia cause of ileus – modern diagnosis and surgical approach
Authors:   Department of HPB and Liver Transplant Surgery, Military Medical Academy, Sofia, Bulgaria, Ivanov Veselin , Marvakov Stefan ,   Department of HPB and Liver Transplant Surgery, Military Medical Academy, Sofia, Bulgaria, Dimov Ventsislav ,   Department of Anesthesiology and Intensive Care, Military Medical Academy, Sofia, Bulgaria, Ivanov Ivan ,   Department of HPB and Liver Transplant Surgery, Military Medical Academy, Sofia, Bulgaria, Strashilov Strahil ,   Department of Reconstructive and aesthetic surgery, UMBAL “Dr. Georgi Stranski”, Medical University, Pleven, Bulgaria, Baikushev Rangel ,   Department of Radiology, Military Medical Academy, Sofia, Bulgaria, Vladov Nikola ,   Department of HPB and Liver Transplant Surgery, Military Medical Academy, Sofia, Bulgaria
Published: January 2023

Introduction: The obturator hernia (OH), which is considered relatively rare, is actually the most common of all hernias types of the pelvic floor. It represents 0.073% of all external hernias. Frequency is greater in older women between the 7th and 9th decades. The male: female ratio is 1:6. It mainly presents with symptoms of small bowel obstruction and accounts for 0.2-1.6% of all causes of ileus. Other concomitant complaints are pain in the thigh radiating to the knee (a symptom of Howship-Romberg) or swelling in the inguinal region with abdominal pain. Case Report: We present an 83 -year -old woman who was admitted to the Surgery department of the Military Medical Academy – Sofia with complaints of abdominal pain, vomiting and stop of defecation for several days. From the tests done, ileus of small intestinal origin was established. The diagnosis of incarcerated, obturator hernia was made after a contrast-enhanced CT scan of the abdomen and pelvis. The patient underwent emergency surgery, during which the incarcerated, small intestinal loop was released, retrograde debarasage of the small intestine and plastic of the obturator channel with its own tissues was done. Conclusions: Small bowel obstruction caused by incarceration in obturator hernia is one of the rare causes of intestinal obstruction in surgery, but on the other hand is a common manifestation in this type of hernia and one of the main causes of its detection. The combination of operative technique for the treatment of ileus condition and the plastic of the obturator channel produces good postoperative results.
EFFORT IN SHAPING THE CHARACTER OF STUDENTS THROUGH EXTRACURRICULAR ACTIVITIES: A STUDY FROM THE EDUCATIONAL MANAGEMENT SCIENCE PERSPECTIVE
Authors: Solehah Siti Mar’atus , Arrohmatan Arrohmatan , Murtafi’ah Nurul Hidayati
Published: January 2023

This research aimed to describe efforts to build students' character through extracurricular activities in the perspective of educational management science at the Hidayatul Mubtadiien Islamic boarding school, Bauh Gunung Sari Sekampung Udik Village, East Lampung city, Indonesia with a descriptive qualitative approach. The focus of the study in this study is how efforts to build students' character through extracurricular activities in the perspective of educational management science and analyze the supporting and inhibiting factors of the organization's activities. This research is based on the results of observations, interviews, and documentation at the research site. The results of the study found that character building was planned in a work program and neatly structured work system, then arranged in a complete and measurable division of tasks based on careful consideration and meeting results, then the work program was carried out in earnest to achieve the target. Achievement and superior character of the students, this activity are also controlled through work evaluations in meetings and direct assessments during extracurricular activities. The supporting factors for the success of forming the character of students through extracurricular activities are the activeness of the student administrators and member students in implementing the program, the provision of prizes for those who are disciplined and achievers, the existence of punishments for those who violate the rules, and the paradigm of students who learn to prepare themselves to take part in society. The inhibiting factors for the success of forming the character of students through extracurricular activities are the lack of facilities and infrastructure, unequal distribution of groups, busyness of students outside of extracurricular activities and the lack of preparation of students in extracurricular activities.
MANAJEMEN PEMBIAYAAN PENDIDIKAN YANG EFEKTIF UNTUK MENINGKATKAN MUTU PENDIDIKAN
Authors: Komariyah Siti , Nurhidayah Nurhidayah , Andriyana Nova , Murtafi’ah Nurul Hidayati
Published: January 2023

Penelitian ini bertujuan untuk menguraikan manajemen pembiayaan pendidikan sebagai upaya untuk meningkatkan mutu pendidikan. Penelitian menggunakan kajian data pustaka berupa buku-buku sebagai sumber data. Penelitian dilakukan dengan membaca, menelaah, dan menganalisis literature seperti buku, artikel, dan karya ilmiah lainnya. Pendidikan merupakan usaha yang dilakukan sebagai investasi dalam menghasilkan manusia-manusia yang memiliki pengetahuan sikap dan keterampilan yang dibutuhkan dalam pembangunan suatu bangsa. Manajemen pembiayaan pendidikan memegang peranan penting dalam meraih tujuan pendidikan dan meningkatkan mutu pendidikan. Salah satu cara untuk meningkatkan mutu pendidikan adalah dengan memperhatikan standar nasional pendidikan yang berlaku di Indonesia diantaranya adalah standar pembiayaan. Kebijakan pendidikan dikembangkan oleh pemerintah pusat daerah dan masyarakat yang mengacu pada UU No. 22 tahun 1999 tentang pemerintahan daerah serta perangkat peraturan yang berlaku. Pembiayaan pendidikan sangat dibutuhkan untuk kebutuhan operasional, dan gaji, kesejahteraan pegawai, peningkatan kegiatan proses belajar mengajar, pemeliharaan dan pengadaan sarana dan prasarana, peningkatan pembinaan kesiswaan, peningkatan kemampuan professional guru, administrasi pendidikan dan pengawasan. Proses belajar mengajar akan meningkat apabila tujuan yang akan dicapai memenuhi persyaratan. Akan tetapi dunia pendidikan di Indonesia masih menghadapi berbagai persoalan yang serius, dari rendahnya alokasi anggaran dari pemerintah.
ANALISIS KRITIS PENDIDIKAN AKHLAK BAGI PESERTA DIDIK (Bangun Rancang Pemikiran Hamka)
Authors: Qurun Khoirotu Alkahfi
Published: January 2023

This article discusses a critical analysis of moral education for students (Prof. Dr.Hamka thinking design). Education today is experiencing a lot of moral decadence and a loss of social values which are marked by promiscuity, drinking, brawls, drugs, and many more things that come out of morality. This is part of deviant behavior among adolescents, youth and society. Furthermore, Hamka, an Indonesian scientist and intellectual figure, Prof. Dr. Hamka. As it is understood that character plays a very important role in shaping a person's attitude and behavior, both as an individual, society and nation, in order to achieve life goals in accordance with the right guidance. Character development becomes urgent, in the midst of developing attitudes and behaviors that conflict with values (norms), both religious and cultural values (norms). This research is library research (Library Research) where the data is obtained from reading and collecting books related to research, such as primary data and secondary data. After getting the data, then the data is processed using the reading method at the symbolic stage, namely reading that is not carried out thoroughly but captures the contents of the data, reading at the semantic level, namely reading in detail, decomposing, and capturing the essence of the data. Then these data were analyzed using the Verstehen, Holistic, and Interpretation methods. Character development based on monotheism values, both textually sourced from the Qur'an and al-Hadith as well as originating from the thoughts of Islamic scientists, such as Hamka reconstructing these thoughts and concepts aims to prepare humans, especially new Muslim scientists who always have an Islamic commitment, as guidelines for the right management of life
IMPLEMENTASI PROBLEM BASED LEARNING PADA PELAJARAN FIQIH MENINGKATKAN HASIL BELAJAR DAN AKTIVITAS PESERTA DIDIK
Authors: Kholidur Rosidi Harun , Iswantir Iswantir , Asnimar Rita
Published: January 2023

Based on the results of daily tests on fiqh subjects, it shows that learning is less successful because it is still below the specified KKM, even though the teacher has explained all the material but has not used good learning methods, only conventional learning models so that students are active in learning, and are less interested in taking fiqh lessons. This study aims to improve the learning outcomes of grade VI students of MIS Bustanut Tholabah in Fiqh subjects. The location of this research is in class VI MIS Bustanut Tholabah Mekar Jaya Village, Jabung District, East Lampung Regency with a total of 15 students. 7 boys and 8 girls. The data in this study were obtained through interviews, action observation results, and evaluation results. This research was carried out in 3 cycles. The results showed that in cycle I, before the action was taken, the average score was 61.67. The average score increased to 74 after the action. The average score increased to 74 after the action. As for student activity, it was found that 73% of students were active. For the evaluation results, only 60% of students reached the KKM. In cycle II, before the action was taken, the average score was 68.33. The average score increased to 73.66 after the action was taken. The average score increased to 73.66 after the action was taken. As for student activity, 77% of students were found to be active. For evaluation results, 70% of students have reached the KKM. In cycle III, before the action was taken, the average score was 68.33. The average score increased to 85 after the action was taken. Cycle III has achieved success of 80% of students who reached the KKM, and student activity reached 90%. Based on the results of the study it can be concluded that learning with a problem-based learning model can improve student learning outcomes, and increase student activity. Learning becomes more fun because students actively participate in all processes of learning activities, this PBL learning model must support TPACK (TECHNOLOGICAL PEDAGOGICAL CONTENT KNOWLEDGE) and requires supporting devices that support learning such as projectors, laptops, and at least more fun media. However, this model is less suitable for children who have limitations or disabilities.
The Effect of Aerobic Exercise on Oxidative Stress in Skeletal Muscle Tissue: A Narrative Review
Authors: Shamsnia Elham , Matinhomaee Hasan , Azarbayjani Mohammad Ali , Peeri Maghsoud
Published: January 2023

Context: Performing intense aerobic exercise leads to an increase in the level of reactive oxygen species (ROS) and a decrease in the level of antioxidant enzymes in body tissues, especially skeletal muscles, and ultimately oxidative stress. Therefore, it is very important to measure oxidative stress before it causes damage to cells and destroys them. Evidence Acquisition: In this review, 92 articles were studied between 2012 and 2022, of which 54 were used. The search was done in Google Scholar, PubMed, Science Direct, and SID databases. An electronic search of studies was done using the keywords ROS, aerobic training, exercise, oxidative stress, antioxidant defense, skeletal muscle, and nuclear factor-erythroid 2-related factor 2 (NRF2). Results: The review of studies conducted in the field of antioxidant adaptations of skeletal muscle shows that the intensity and duration of activity are the main factors in controlling (creating or preventing) oxidative stress in skeletal muscle tissue. Also, taking antioxidant supplements before ROS levels reach peak physiological performance can reduce the beneficial effects of exercise. On the other hand, antioxidant treatment, after maximal performance related to ROS, can lead to reduced fatigue and/or improved performance. Conclusions: It seems that the increase in oxidative stress caused by aerobic exercise is a function of the amount of ROS production and the internal and external antioxidant defense capacity of the individual. However, different types of aerobic exercise along with various antioxidant supplements need to be performed for a long time in different people in order to achieve better approaches to early prediction of oxidative stress and reducing the destructive effects of skeletal muscle.
Effect of 12-Week Aerobic Exercise Training on Chemokine Ligands and Their Relative Receptors in Balb/C Mice with Breast Cancer
Authors: Esmailiyan Mehrnoosh , Nobari Hadi , Kargarfard Mehdi , Amerizadeh Atefeh , Esfarjani Fahimeh , Vaseghi Golnaz , Badicu Georgian , Prieto González Pablo , Ardigo Luca Paolo
Published: January 2023

Background: Some chemokines like C C motif chemokine ligand (CCL) 2 and 5 and their receptors (CCR) 2 and 5 are mediators of chronic inflammation and cancer development. Moreover, physical exercise can increase the activity of antioxidant enzymes. However, its effect on cancer cells has not been reported at present. Objectives: Therefore, the present study aimed to ascertain the effect of 12-week aerobic exercise training (AET) on CCL2, CCR2, CCL5, and CCR5 in mice with breast cancer. Methods: Sixteen Balb/c mice aged 4 - 5 weeks (n = 16; approximate weight: 18 ± 2 g) were divided into two groups: AET group (AETG) and control group (CG) (n = 8 per group). The AETG performed 12-week treadmill running at 18 m/min for 40 min and five times a week. Plasma levels of CCL2 and CCL5 were measured by ELISA, and the CCR2 and CCR5 were evaluated by Western blotting. Two independent sample t-test was applied to compare the differences between AETG and CG. Results: The analysis displayed after 12 weeks showed a significant reduction in AETG compared to CG in CCL2 (3.94 ± 1.12 vs. 15.40 ± 3.29 pg/mL; P = 0.001), CCR2 (0.56 ± 0.19 vs. 1.00 ± 0.001; P = 0.002), CCL5 (138.59 ± 15.72 vs. 267.57 ± 49.06 ng/mL; P = 0.001) and CCR5 (0.36 ± 0.12 vs. 1.00 ± 0.001; P = 0.001), respectively. Conclusions: We concluded that one of the main mechanisms of a positive effect of exercise on breast cancer is reducing the inflammation via CCL2 and CCL5 and their related receptors CCR2 and CCR5, respectively. Since these molecules can be triggered off oxidative stress and tumorigenesis, these results can pave the way for further studies in this field.
Evaluation Awareness of Parents About Use of Medications in Children
Authors: Safi Samghabadi Laila , Taherahmadi Hassan , Yousefichaijan Parsa , Rafiei Mohamad , Karimi Matloub Saeed , Rezagholizamenjany Masoud
Published: January 2023

Background: Proper use of medications in outpatients, as an important issue, especially in children, should be considered. Objectives: The aim of present study was to evaluate the awareness of parents about the consumption of medications. Methods: This interventional study was conducted on patients’ parents referred to Amir Kabir Hospital. First, a medical history was taken, and then they completed a compiled questionnaire. After completing the checklist by parents, they were educated about general information on how to use medicines. Before and after the education about the proper use of medications, data were analyzed by SPSS software. Results: From one hundred evaluated cases, the mean and standard deviation (SD) of age were 4.3 ± 2.4. In addition, we observed statistically significant differences between the level of parental awareness before and after the intervention. Conclusions: In parents with any level of education, training about the proper use of medications is necessary and important.
Vitamins D and E Improve Valproic Acid-Induced Autistic-Like Behaviors and Oxidative Stress in the Rat Offspring
Authors: Abbarin Davood , Vafaei Abbas Ali , Rashidy Pour Ali , Bandegi Ahmad Reza , Taherian Abbasali , Rahmani Mehrnoosh , Jarrahi Morteza , Sedaghat Katayoun
Published: January 2023

Background: Autism spectrum is a type of developmental-neurodegenerative disease commonly reflected in social communications and associated with oxidative stress in the brain. Vitamins D and E, as strong antioxidants, may improve autistic-like behavioral disorders. Objectives: The aim of this study was to determine the effects of vitamins D and E on pain, threshold, motor coordination, and anxiety behavior, as well as oxidative stress parameters in an autistic model in rats. Methods: We induced an experimental model of congenital autism in the rat by injection of valproic acid (500 mg/kg) into pregnant rats on the day 12.5th of gestation. From postnatal day 30 to 60, male offspring received daily injections of vitamins D (5 µg/kg) and/or E (10 mg/kg) or vehicle. Next, their anxiety levels were assessed with the elevated plus maze and open field, pain thresholds with hot plate, motor and balance with rotarod, and spatial learning and memory with T-maze. The rat brain was then removed to measure oxidative markers, including Malondialdehyde, Glutathione, and Catalase. Results: Results indicated that injection of valproic acid-induced autistic-like behaviors, including increased pain threshold, increased anxiety, decreased exploring behaviors, reduced balance power, and motor learning, and produced oxidative stress. Administration of vitamins D and E significantly ameliorated these symptoms. Conclusions: These findings may indicate that vitamins D and E improved sensory, motor, anxiety, and cognitive deficits in an experimental model of autism, probably by reducing the oxidative stress and inflammatory process or maintaining balance in the neurotransmitter system.
Effects of Rehabilitative Exercises on Swallowing Function in Elderly People: A Pilot Randomized Controlled Trial
Authors: Ebrahimian Dehaghani Shiva , Bakhtiyari Jalal , Salmani Masoomeh , Shahabi Saba , Tahooneh Ali , Alibakhshi Hossein
Published: January 2023

Background: Swallowing problems are common in healthy elders. Swallowing difficulties are the cause of medical and psychosocial complications in old age. Thus, to prevent and minimize these complications, diagnosis and proper interventions are important. Objectives: This study aimed to investigate the effects of rehabilitative exercises on swallowing function and quality of life in older adults. Methods: A total of forty healthy elders were randomly assigned to the rehabilitative exercises group (n = 20) and the compensatory group (n = 20). Inclusion criteria in this study were as follows: age 60 - 80; the presence of swallowing problems assessed clinically by a speech therapist; no history of swallowing treatment, pneumonia or head and neck surgery, and other neurological or general disorders that can influence swallowing function. Randomization was undertaken using a block randomization technique. Rehabilitative exercises, including muscle strengthening exercises, were used in 3 sets of 10 per muscle group and three times per week for one month for the rehabilitative exercise group. In order to evaluate the outcomes, the Mann Assessment of Swallowing Ability (MASA) and the P-dysphagia handicap index (P-DHI) were administered. Statistical analysis of data was done by the use of parametric statistical tests such as independent t-test, paired sample t-test, and nonparametric tests such as Mann-Whitney test, and P-value ≤ 0.05 was considered to be statistically significant. Results: There were no significant differences between the two groups regarding demographic and clinical swallowing function before intervention (P ≤ 0.05). There was a significant improvement in the clinical function of swallowing and swallow-related quality of life in the group which received the rehabilitative exercises compared to the group that received only the compensatory methods (P < 0.001). Conclusions: Our research has indicated that swallowing rehabilitative exercises are more effective in improving clinical swallowing function in elderly persons than compensatory exercises.
La Renaissance, en passant par la Lorraine
Authors: Roudet Nicolas
Published: January 2023

Cet article est un compte-rendu du livre : Europe XVI-XVII, n° 20, n° 21 et n° 22 : « La Renaissance en Europe dans sa diversité », n° 20 : « Les pouvoirs et lieux de pouvoir » publié sous la direction de Gérard Giuliato, Marta Peguera Poch & Stefano Simiz, 558 p., EAN 9782917030097 ; n° 21 : « Les savoirs, les savoir-faire et leurs transmissions », publié sous la direction de Patrizia Gasparini, Danielle Morali, Roseline Théron & Hélène Vacher, 530 p., EAN 9782917030103 & n° 22 : « Circulation des hommes, des idées et des biens, héritages », publié sous la direction de Lioudmila Chvedova, Michel Deshaies, Stanisław Fiszer & Marie-Sol Ortola, 560 p., EAN 9782917030110.
Dits & Écrits d’André Malraux : quelques inédits
Authors: Travi Claude
Published: January 2023

Cet article est un compte-rendu du livre : Jacques Chanussot & Claude Travi, Dits et Écrits d’André Malraux. Bibliographie commentée, nouvelle édition revue et augmentée, avant‑propos de Jean‑Claude Larrat, Dijon : Éditions Universitaires de Dijon, coll. « Écritures », 2016, 813 p., EAN 9782364411807.
Shakespeare, un héritage juridique
Authors: Cot Guillaume
Published: January 2023

Cet article est un compte-rendu du livre : Dominique Goy‑Blanquet, Côté cour, côté justice. Shakespeare et l’invention du droit, Paris : Gallimard, coll. « Esprit des Lois, Esprit des Lettres », 2016, 542 p., EAN 9782406057277.
Poètes, traducteurs & correcteurs
Authors: Tachet Marie‑Pierre
Published: January 2023

Cet article est un compte-rendu du livre : Pauline Galli‑Andreani, Mallarmé, Valéry et Claudel traducteurs, Paris : Presses Universitaires de Vincennes, coll. « L'Imaginaire du Texte », 2016, 320 p, EAN 9782842925321.
Dynamique(s) du groupe littéraire : microsociologies d’un objet polymorphe
Authors: Côté Julien
Published: January 2023

Cet article est un compte-rendu du livre : La Dynamique des groupes littéraires, sous la direction de Denis Saint-Amand, Liège : Presses Universitaires de Liège, coll. « Situations », 2016, 192 p., EAN : 9782875621047.
Le « méloforme » : mort & transfiguration(s) d’une aporie
Authors: Perreault Isabelle
Published: January 2023

Cet article est un compte-rendu du livre : Frédéric Sounac, Modèle musical et composition romanesque. Genèse et visages d’une utopie esthétique, Paris : Classiques Garnier, coll. « Perspectives comparatistes », 2014, 568 p., EAN 9782812430404
Derrida de l'intérieur, Derrida de l'extérieur
Authors: Christophe Cosker sans prénom
Published: January 2023

Cet article est un compte-rendu du livre : Dominique Maingueneau & Mathilde Vallespir (dir.), Lire Derrida ? Autour d’Eperons. Les styles de Nietzsche, Limoges, Lambert–Lucas, coll. « Le Discours philosophique », 2015, 132 p., EAN : 9782359351279.
Pour une anti‑polémologie du savoir. Les structures discursives de l’Occident
Authors: Meunier Marine
Published: January 2023

Cet article est un compte-rendu du livre : Bertrand Westphal, La Cage des méridiens. La littérature et l’art contemporain face à la globalisation, Paris, Les Éditions de Minuit, coll. « Paradoxe », 2016. EAN : 9782707329585.
Sous les apparences d’une illisibilité
Authors: Caillé Anne-Renée
Published: January 2023

Cet article est un compte-rendu du livre : Bénédicte Gorrillot, Alain Lescart (dir.), L’Illisibilité en questions. Avec Michel Deguy, Jean-Marie Gleize, Christian Prigent, Nathalie Quintane, Septentrion, coll. « Littératures », mai 2014. ISBN: 9782757407417.
Itinéraire intellectuel & spirituel d’un francophoniste
Authors: Clavaron Yves
Published: January 2023

Cet article est un compte-rendu du livre : Charles Bonn, Lectures nouvelles du roman algérien. Essai d’autobiographie intellectuelle, Paris, Classiques Garnier, « Bibliothèques francophones », 2016, 280 pages. EAN :9782812451072
Propagation diffuse
Authors: Coste Didier
Published: January 2023

Cet article est un compte-rendu du livre : Approches interdisciplinaires de la lecture nº10 – La résonance lectorale, sous la direction de Marie‑Madeleine Gladieu, Jean‑Michel Pottier & Alain Trouvé, Reims : Épure, 2016, 226 p, EAN 9782374960142.
Amplitudes poétiques
Authors: Reymond Emmanuel
Published: January 2023

Cet article est un compte-rendu du livre : Gaëlle Théval, Poésies ready-made, xxe-xxie siècles, Paris : L’Harmattan, coll. « Arts & médias », 2015, 288 p., EAN 9782343069449
L’Asie de Paul Claudel
Authors: Bruckert Thomas
Published: January 2023

Cet article est un compte-rendu du livre : Jacques Houriez, Paul Claudel rencontre l’Asie du tao. Paris : Honoré Champion, 2016, coll. « Poétiques et Esthétiques xxe-xxie siècle », 326 p. EAN : 9782745331304.
Le mystère Tintin. Du bon usage de la structure, & au-delà
Authors: Nattiez Jean-Jacques
Published: January 2023

Cet article est un compte-rendu du livre : Renaud Nattiez, Le mystère Tintin. Les raisons d’un succès universel, Paris : Les Impressions Nouvelles, 2016, 366 p., EAN 9782874493096.
Le théâtre est-il pensable ?
Authors: Chaperon Danielle
Published: January 2023

Cet article est un compte-rendu du livre : Olivier Saccomano, Le Théâtre comme pensée, Besançon, Les Solitaires intempestifs, 2016.
Lire pour agir : les vertus pédagogiques de la fiction
Authors: Feller Sophie
Published: January 2023

Cet article est un compte-rendu du livre : Augustin Voegele, Morales de la fiction de La Fontaine à Sartre, Paris, Orizons, coll. « Comparaisons », 2016, 156 p., EAN 9791030900835.
« Parler comme l’image » : du discours des catalogues d’expositions et du groupe surréaliste
Authors: Reverseau Anne
Published: January 2023

Cet article est un compte-rendu du livre : Colette Leinman, Les Catalogues d’expositions surréalistes à Paris entre 1924 et 1939, Amsterdam, New York, Brill / Rodopi, coll « Faux Titre 401 », 2015, 318 p., EAN 9709042039179
Les Âges de la poésie chinoise en France
Authors: Vinclair Pierre
Published: January 2023

Cet article est un compte-rendu du livre : Yu Wang, La Réception des anthologies de poésie chinoise classique par les poètes français (1735-2008), Paris, Classiques Garnier, coll. « Études de littérature des xxe et xxie siècles », 2017, 779 p., EAN 978240606282
Récits d’intellectuels allemands sur la Ville Lumière et ses révolutions
Authors: Deffarges Anne
Published: January 2023

Cet article est un compte-rendu du livre : Gerhard R. Kaiser (éd.), Deutsche Berichte aus Paris, 1789-1933. Zeiterfahrung in der Stadt der Städte, Göttingen : Wallstein, 2017, 550 p., EAN 9783835330184.
La chambre noire de Germaine de Staël
Authors: Baudoin Sébastien
Published: January 2023

Cet article est un compte-rendu du livre : Stéphanie Genand, La Chambre noire. Germaine de Staël et la pensée du négatif, Genève, Droz, 2017, 381 p. EAN 9782600047388.
Dans le leurre des mots : la dialectique du traducteur
Authors: Tachet Marie-Pierre
Published: January 2023

Cet article est un compte-rendu du livre : Stéphanie Roesler, Yves Bonnefoy et Hamlet - Histoire d'une retraduction, Paris, Classiques Garnier, coll. « Perspectives comparatistes », 2016, 359 p., EAN : 9782812451287.
« La flamme éteinte se rallume » : lecture du livre VII des Métamorphoses d’Ovide nouvellement traduites par Marie Cosnay
Authors: Pichot Pierre-Élie
Published: January 2023

Cet article est un compte-rendu du livre : Ovide, Les Métamorphoses, trad. Marie Cosnay, éditions de l'Ogre, Paris, octobre 2017, 165/218 mm, 528 p., EAN : 9791093606996.
« Idole individuelle » & histoire du livre
Authors: Lesage Sylvain
Published: January 2023

Cet article est un compte-rendu du livre : Olivier Bessard‑Banquy, La Fabrique du livre. L’édition littéraire au XXe siècle, Bordeaux : Presses universitaires de Bordeaux & Du Lérot éditeur, 2016, 510 p., EAN 9791030000917.
La littérature résistante ou les nouvelles Humanités Scientifiques
Authors: Dumouchel Suzanne
Published: January 2023

Cet article est un compte-rendu du livre : Martial Poirson, Politique de la représentation. Littérature, spectacle, discours de savoir (xviie‑xxie siècles), Paris : Honoré Champion, coll. « Le dialogue des Arts», 2014, 266 p., EAN 9782745327987.
Le statut logique de la fiction (médiévale)
Authors: Moran Patrick
Published: January 2023

Cet article est un compte-rendu du livre : Virginie Greene, Logical Fictions in Medieval Literature and Philosophy, Cambridge University Press, 2014, 322 p, EAN 9781107068742.
Représentations du sida, d’hier à aujourd’hui
Authors: Rossi Silvia
Published: January 2023

Cet article est un compte-rendu du livre : Alessandro Badin, Stefano Genetti, Fabio Libasci & Jean-Marie Roulin (dir.), Littérature et sida, alors et encore, Leiden / Boston : Brill / Rodopi, coll. « CRIN », vol. 62, 2016, 144 p., EAN 9789004322790.
Qui a peur de l’imitation ? C’est pas nous…
Authors: Julliot Caroline
Published: January 2023

Cet article est un compte-rendu du livre : Maxime Decout, Qui a peur de l’imitation ?, Paris : Les Éditions de Minuit, coll. « Paradoxe », 2017, 160 p. EAN 9782707343123.
À une passante très étrangère
Authors: Coste Didier
Published: January 2023

Cet article est un compte-rendu du livre : Claudine Le Blanc, Les Livres de l’Inde : une littérature étrangère en France au XIXe siècle, Paris, Presses Sorbonne Nouvelle, 2014, 236 p., EAN 9782878546361.
Investissements & désinvestissements de la langue en contexte juif
Authors: Rousselet Cécile
Published: January 2023

Cet article est un compte-rendu du livre : Keren Mock, Hébreu, du sacré au maternel, Paris : CNRS Éditions, coll. « Philosophie et histoire des idées », 2016. EAN13:9782271087379
Le paradigme Angot, ou la fin des haricots ?
Authors: Huppe Justine
Published: January 2023

Cet article est un compte-rendu du livre : Vincent Kaufmann, Dernières nouvelles du spectacle. Ce que les médias font à la littérature, Paris : Seuil, 2017, 274 p.EAN 9782021374766.
Circulating Oral Poetry in “Reel” Time
Authors: O’Neill Sean
Published: January 2023

Cet article est un compte-rendu du livre : Flagg Miller, The Moral Resonance of Arab Media. Audiocassette Poetry and Culture in Yemen, Cambridge : Harvard University Press, 2007, 525 p., EAN 9780932885326.
Le XXe siècle déchiffré grâce à une paire de ciseaux : le cut‑up & ses corollaires
Authors: Anysia Troin‑Guis sans prénom
Published: January 2023

Cet article est un compte-rendu du livre : Clémentine Hougue, Le Cut‑Up de William S. Burroughs. Histoire d’une révolution du langage, Dijon : Les Presses du réel, 2014, 416 p., EAN 9782840667117.
Misérables Misérables
Authors: Laforgue Pierre
Published: January 2023

Cet article est un compte-rendu du livre : Victor Hugo, Les Misérables, édition établie par Henri Scepi, avec la collaboration de Dominique Moncond’huy, Paris : Gallimard, coll. « Bibliothèque de la Pléiade », 2018, 1734 p. + p. IX-LXXXVII, EAN 9782070142224.
Robbe-Grillet : le Nouveau Roman et après
Authors: Sirvent Michel
Published: January 2023

Cet article est un compte-rendu du livre : Roger-Michel Allemand(éd.), Alain Robbe-Grillet. Entretiens complices, Paris : Éditions EHESS, coll. « Audiographie », 2018, 204 p., EAN 9782713227608.
Ce que la fiction fait à la Révolution (et inversement)
Authors: Roman Myriam
Published: January 2023

Cet article est un compte-rendu du livre : Jean-Marie Roulin et Corinne Saminadayar-Perrin (dir.), Fictions de la Révolution. 1789-1912, Presses universitaires de Rennes, coll. « Interférences », 2017, 362 p., EAN 9782753565180.
« Il montait dans une chaire magistrale et prêchait le sermon sur le dandysme »
Authors: Richard Philippe
Published: January 2023

Cet article est un compte-rendu du livre : Alain Montandon (dir.), Dictionnaire du dandysme, Paris, Champion, coll. « Dictionnaires & références » n° 37, 2016, 728 p., ISBN  9782745329592
Les rires de Paris : théâtre & comique à la fin du XVIIIe siècle
Authors: Cot Guillaume
Published: January 2023

Cet article est un compte-rendu du livre : Stéphanie Fournier, Rire au théâtre à Paris à la fin du XVIIIesiècle, Paris : Gallimard, coll. « L’Europe des Lumières », 2016, 779 p., EAN 9782406058519.
La Vie parisienne ou la fabrique médiatique de la mondanité
Authors: Jarrasse Bénédicte
Published: January 2023

Cet article est un compte-rendu du livre : Clara Sadoun‑Édouard, Le Roman de La Vie parisienne. Presse, genre, littérature et mondanité (1863‑1914), préface de M. le Professeur Philippe Hamon, Paris, Honoré Champion, coll. « Romantisme et modernités », n° 180, 2018, 570 p., EAN 9782745346339.
Les passants d’Idomeni
Authors: Gannier Odile
Published: January 2023

Cet article est un compte-rendu du livre : Georges Didi-Huberman & Niki Giannari, Passer, quoi qu’il en coûte, Paris : Les Éditions de Minuit, 2017, 104 p., 11 illustrations in-texte, ISBN : 9782707343901
Visages de l’altérité. Figures de femmes étrangères en Suisse romande au tournant du XIXe siècle
Authors: Rousselet Cécile
Published: January 2023

Cet article est un compte-rendu du livre : Océane Guillemin, D’Hélène à Lilith. Figures de femmes étrangères en Suisse romande (1890-1914), postface de Daniel Maggetti, Lausanne, Archipel Essais, vol. 25, 2017. ISBN 9782940355242, 140 p.