bluuebunny/crossref_metadata_2025 huggingface dataset:
SALICYLATE TOXICITY INTENSIVE CARE MANAGEMENT IN CHILDREN
Authors:   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation, Bykov Yuriy , Obedin Aleksandr ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation,   Stavropol Regional Clinical Perinatal Center No. 1, Stavropol, Russian Federation, Fischer Vasiliy ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation,   Shpakovskaya District Hospital, Mikhaylovsk, Russian Federation, Volkov Evgeniy ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation,   Stavropol Regional Clinical Hospital, Stavropol, Russian Federation, Zinchenko Oleg ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation, Muravyova Alla ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation, Yatsuk Ivan ,   Department of Anesthesiology and Resuscitation with a Course of Additional Professional Education, Stavropol State Medical University, Stavropol, Russian Federation,   Stavropol City Clinical Emergency Hospital, Stavropol, Russian Federation
Published: December 2024

A review of the literature on intensive care (IC) management of acute salicylate (SC) toxicity in children and adolescents was conducted. The information
was gathered from the PubMed, Science Direct, and eLibrary databases using the keywords: "salicylates", "children", "adolescents", "acute poisoning",
"overdose", and "intensive care." The review included sources published over the last 10 years (2014-2024). The criteria for including studies in the
review were data regarding the pathogenesis, clinical manifestations, and specific features of IC for SC poisoning in children and adolescents. Works
that focused exclusively on adult patients were excluded from the review. Although the drugs are known to be contraindicated in children, acute SC
poisoning continues to be common in pediatric practice. The clinical manifestations are nonspecific and may include central nervous, gastrointestinal,
and respiratory disturbances. Measuring plasma SC concentration is a crucial diagnostic test for assessing the severity of poisoning. The effectiveness
of gastric lavage has not been proven, and adsorbents are only justified within the first two hours after exposure. Effective IC methods for SC poisoning
include infusion therapy, urinary alkalinization using sodium bicarbonate, and extracorporeal treatment. With modern and adequate emergency care,
the prognosis for recovery is considered favorable.
Keywords: Salicylates, acetylsalicylic acid, children and adolescents, poisoning, intensive care.
CANABIDIOL E SUAS POSSÍVEIS APLICAÇÕES TERAPÊUTICAS NA ODONTOLOGIA UMA REVISÃO DE LITERATURA
Authors: Souza e Silva Monique , Menezes Raquel Teles de , Cintra Tuana Mendonça Faria , Pereira Thais Cristine , Marcucci Maria Cristina , Oliveira Luciane Dias de , Domiciano Vanessa Marques Meccatti
Published: December 2024

As propriedades terapêuticas da planta Cannabis sativa L. é de conhecimento popular desde os povos antigos e, devido a mudanças socioculturais, sua utilização para fins terapêuticos foi reduzida. Entretanto, nos últimos anos, a busca por pesquisas científicas sobre esses efeitos terapêuticos e o incentivo de seu uso tem crescido largamente em todo mundo. O objetivo desta revisão bibliográfica é apresentar a história da planta Cannabis com uso medicinal e evidenciar seus benefícios para a odontologia. Com base em artigos encontrados nas plataformas SciELO, Pubmed e Google acadêmico, foram reunidas informações a respeito da trajetória do uso da planta na medicina e como ela interage com o nosso organismo. Deste modo, as evidências demonstram muitos benefícios para odontologia, como tratamentos de mucosites orais, devido ao efeito antioxidante e anti-inflamatório dos derivados da planta, de doenças periodontais, também pelo potencial de combate a inflamação e pela capacidade antimicrobiana e dor orofacial, uma vez que são considerados analgésicos potentes. Em geral, esta coletânea sugere que as substâncias advindas da planta, como o canabidiol, possuem propriedades biológicas promissoras e o crescente interesse nas pesquisas sobre plantas medicinais e seus fitocompostos fomentam a divulgação e os estudos sobre as aplicações da Cannabis sativa L. em odontologia.
LA DIMENSIÓN TEXTUAL DEL ANÁLISIS INTERACCIONAL DEL DISCURSO EN LOS DISCURSOS POLÍTICO Y RELIGIOSO
Authors: Duarte Alvarado Mercedes
Published: December 2024

El Análisis Interaccional del Discurso (AID) es un modelo teórico para comprender la lengua en sociedad. El objetivo de este trabajo es dilucidar los alcances del estudio de la dimensión textual del AID en una interacción macrodiscursiva entre el Gobierno venezolano y la Iglesia católica. La hipótesis propone que las elaboraciones semánticas de la experiencia tendrían que ser distintas entre los participantes involucrados. Los resultados revelan que en el plano sociosemiótico la interacción es polémica, aunque se construyen campos semánticos afines. Finalmente, las potenciales diferencias y el carácter controversial del intercambio deben analizarse en las interacciones interpersonal y macrodiscursiva.
DE LA VIRTUALIDAD A LA INTELIGENCIA ARTIFICIAL EN EL ÁREA DE LA ENSEÑANZA DEL ESPAÑOL COMO LENGUA EXTRANJERA
Authors: García Fernández María
Published: December 2024

This article reviews the concepts of virtuality and artificial intelligence applied to teaching Spanish as a foreign language. It analyzes how these models are integrated to create accessible learning environments for the acquisition of second or foreign languages. Virtuality facilitates distance learning through digital platforms, while artificial intelligence promotes personalization and interactivity of learning. The present research provides a classification of these technologies within the area of ​​Spanish teaching, highlighting their benefits and limits.
LA EVALUACIÓN INCLUSIVA PARA UNA EVALUACIÓN JUSTA
Authors: Romero-González Luis M
Published: December 2024

In a democratic society that upholds values such as social justice, all  individuals have the right to a quality education that enables them to fully develop  their abilities and integrate into all facets of society. In this review article, we  emphasize that achieving such quality education requires a crucial role for  assessment, as education and assessment must go hand in hand. Currently,  assessment aims to be as fair as possible to all learners. After reviewing several works  in this area, the current literature leans towards the idea that, to be fair and to meet  the needs of each student, one of the purposes of assessment is to regulate the  teaching and learning process through its formative function so that all students can  learn, focusing on equity to tailor the assessment to each individual. However,  assessment is a complex process that also has other assigned functions, such as  accounting for each student's learning by following objective and equal evaluation  criteria for all, valuing a fair assessment as one that allows for comparison of results  among individuals and institutions. This creates a dichotomous debate about what  constitutes a fair assessment: one that treats everyone equally, in an egalitarian,  objective manner, valuing justice as treating everyone as equals; or one that adjusts  to the needs of each student, more subjective, and sensitive to the individual differences of each person. The inclusive assessment approach leans towards equity,  offering opportunities to all students based on multiple factors that generate  diversity, not only addressing the presence of disabilities or special educational  needs, but all students. It concludes that an inclusive assessment is one that  understands that all students can learn, that is critical of traditional assessment  procedures which, through deeply rooted practices (timed tests, inflexible  instruments in time and format, exams as the main assessment tool…), favor certain  types of students while excluding others. It is one that is based on the three  principles of educational inclusion: presence, participation, and achievement, to  serve learning, as opposed to traditional assessment, which, conversely, promotes  learning to be at the service of assessment.
EDUCAR EN LOS VALORES CRISTIANOS DE LA CREACIÓN PARA UNA EDUCACIÓN EN LA PAZ DESDE EL INTERIOR
Authors: LUCAS IMBERNÓN MARÍA AUXILIADORA , NAVARRO MAZÓN MARÍA ÁNGELES , GONZÁLEZ ALONSO FERNANDO
Published: December 2024

El tema elegido para esta comunicación es la educación en los valores cristianos  de la creación, que constituye un elemento fundamental para la educación en la  paz desde una dimensión trascendente. Para ello, como dice el Papa Francisco  en Laudato Si’ (2015), es necesario actualizar el mensaje cristiano y educar en la  ecología humana haciendo conscientes a los más jóvenes de la responsabilidad  de cuidar, no solo de la naturaleza, sino de toda la persona humana. Es  necesario enseñar y educar en la responsabilidad moral de que todo lo creado es  un regalo de Dios al ser humano, y que este regalo es necesario cuidarlo (LS 5).  En este trabajo se pretende mostrar que actualizar el mensaje cristiano a través  de la ecología integral es fundamental para poner las bases de una educación  integral que abarque a toda la persona y todas sus dimensiones. En él se  desarrollará el concepto de la ecología cristiana, como nueva concepción para  actualizar los valores humanos y cristianos. Con los conceptos de la eco teología  aportados por el eco teólogo Leonardo Boff (Brasil, 1938), así como la  aportación que ha hecho el Papa Francisco en su amplio magisterio al tema de la  ecología integral y la ecología cristiana, reflexionaremos cómo no se puede  olvidar que todo en la creación está unido: la suerte del planeta está unida a la  del ser humano. Como resultado tendremos una propuesta educativa que  consistirá en educar en una nueva ecología social, económica y espiritual que  aportará una nueva visión a la hora de plantear la educación en valores.  Finalmente, con este trabajo se quiere exponer que educar a las nuevas  generaciones en los valores fundamentales de la creación a través de la ecología  integral, es establecer bases fundamentales para construir personas íntegras y capaces de realizar cambios estructurales que posibiliten sociedades más  fraternas, solidarias y pacíficas.
Operational investigative activities of criminal investigation officers to identify stolen property in the context of digitalization
Authors: Namsaraev Anchig CHingizovich
Published: December 2024

within the framework of the conducted research, the author comes to the con-clusion that currently the practice is experiencing an acute shortage of scientific and methodological materials to ensure compensation for material damage caused as a result of crimes against property. The subject of this study is the specifics of the activities of the criminal investigation units of the internal affairs bodies of the Russian Federation to find and identify stolen property, as a result of the commission of a crime for non-obvious crimes, that is, when the person who committed the crime has not been identified, as well as after the arrest of a suspect in the commission of a crime. Based on the analysis of empirical mate-rials, the author identified a general characteristic of damage compensation ac-tivities, the total amount of stolen property. The purpose of the study is to iden-tify some problems and solutions for finding and identifying property stolen during the commission of crimes. The methodological basis of the research is formed by dialectical, formal-logical, system-structural, statistical methods, as well as the method of statistical analysis and other methods of scientific re-search. The main measures aimed at organizing the activities of employees of criminal investigation departments to identify stolen property are considered. The scientific novelty lies in the development of recommendations, through the conduct of operational investigative measures aimed at organizing the activities of employees of the criminal investigation units of the internal affairs bodies of the Russian Federation to identify the person who committed the crime, to find stolen property, as well as the actions of employees of the criminal investigation units of the internal affairs bodies of the Russian Federation, when detaining a suspect, if not The location of the stolen property has been established.
The tribal structure and localities of the Tungus nomads of the Department of the Kangalas Tungus clans in the XIX-early XX century
Authors: Vinokurov Aleksandr Danilovich , Vinokurova Olga Egorovna , Gogoleva Daiana Aisenovna , Prokopieva Nyurguiaana Innokentyevna
Published: December 2024

The subject of this study is the generic composition of the Tunguses (Evenks) of the Department of the Kangalas Tungus clans in the XIX – early XX century. The purpose of the study is to identify and study documentary and statistical sources in the collections of the National Archive of the Republic of Sakha (Yakutia), which contain information about the administrative-territorial structure, ancestral composition, demography and places of nomadism. General scientific methods (analysis, systematic approach) were used in the study so are special methods (historicism, historical-genetic, archival heuristics) of research. The place of the Administration in the system of administrative and territorial administration, its functions and tasks were studied by the method of analysis. The systematic approach allowed us to identify the characteristic principles of the management structure. The principle of historicism allowed us to consider the Administration in the dynamics of development, the prospect of changing historical events. The historical-genetic method requires an approach to Management as a phenomenon that naturally arose in a certain historical setting. The method of archival heuristics made it possible to identify the affairs of the Board in an array of documents from other funds. The method of archival heuristics made it possible to identify the affairs of the Board in an array of documents from other funds. As a result of the work carried out, a nomenclature of the generic composition, a list of nomadic Kangalas Tunguses on the territory of the Aldan, Amginsky, Gorny, Neryungrinsky and Khangalassky districts of the RS(Ya) was compiled. The novelty lies in the introduction into scientific circulation of previously unpublished archival documents on the declared topic. Based on the results of the work, it was concluded that further research is necessary due to the presence of a large number of unpublished documents.
Terapia ocupacional y el infante prematuro
Authors: Ferro Maritza
Published: December 2024

El fin de este artículo es presentar a los lectores la importancia de la acción-intervención de Terapia Ocupacional en el cuidado de infantes de alto riesgo. Para el logro de esto, se parte de una revisión teórica que señala, respecto al bebé, alteraciones a nivel del tono, del estado de alerta, de la alimentación entre otras; y respecto al ambiente, alteraciones referidas a los estímulos, a la relación con los padres etc. y donde tanto las unas como las otras limitan la ejecución de un rol ocupacional del bebé. Tomando como base lo anterior, se enfatiza la forma de acción de Terapia Ocupacional en lo concerniente al bebé como tal y como participante en el mundo que lo rodea y con el cual establece relaciones que le posibilitan adaptación y competencia, teniendo en cuenta finalmente que a lo largo de este proceso se debe dar una relación dinámica entre el bebé, el grupo de profesionales que intervienen con él y sus padres.
La terapia ocupacional hacia el siglo XXI
Authors: Trujillo Rojas Alicia
Published: December 2024

Esta ponencia examina el porvenir de la terapia ocupacional colombiana a la luz de las condiciones de la vida moderna y el estado evolutivo de la profesión. El tema se desarrolla a partir de los siguientes contenidos: a) Las exigencias que el progreso científico y tecnológico imponen a las universidades y a los profesionalesb) La evolución colombiana en cuanto a apoyo estatal a la ciencia y la tecnología c) La posición de la terapia ocupacional internacional respecto a los logros que requiere la profesión en la sociedad postmoderna, y d) Los retos que representa para la terapia ocupacional colombiana ese contexto nacional e internacional.
La segunda parte de la ponencia sustenta cuatro estrategias conducentes a que la terapia ocupacional pueda asumir una posición de vanguardia en la sociedad de finales de siglo. Estas son la evaluación y el fortalecimiento de los programas de nivel profesional; el apoyo a la formación postgraduada; el incremento en la calidad de los servicios y el establecimiento de relaciones de intercambio nacional e internacional. La autora postula que las cuatro estrategias son instrumentales para el crecimiento científico y tecnológico, el cual contribuirá a vigorizar la actuación y el protagonismo nacional e internacional de la terapia ocupacional colombiana.
Este artículo examina el porvenir de la terapia ocupacional colombiana frente a los retos de la vida moderna. El título tiene la intención de resaltar que debemos ser acreedores a ingresar en el siglo veintiuno. Para merecer ese privilegio es urgente comprometerse con un desarrollo dirigido al mañana, de acuerdo con la realidad colombiana y el avance mundial. No prever las demandas del futuro implicará una creciente situación de desventaja para la profesión. El tema se desenvuelve a partir de cuatro argumentos, a saber: (a) la ciencia y la tecnología son realidades decisivas en la universidad y la sociedad de finales de siglo;(b) a partir de los años ochenta, el Estado colombiano adquiere creciente conciencia sobre la urgencia de hacer efectivo su apoyo a la ciencia y la tecnología; (c) durante el transcurso del siglo veinte, la terapia ocupacional de los países avanzados denota una tendencia ascendente del nivel académico, la producción científica y el respaldo tecnológico; y (d) la evolución de la sociedad contemporánea plantea a la terapia ocupacional colombiana retos que implican demostrar su avance científico y tecnológico como condición para perdurar en el mañana. Puesto que es ineludible afrontar esos desafíos, la sección final de la ponencia plantea cuatro estrategias de acción a corto y a mediano plazo.
Faktor risiko yang berhubungan dengan komplikasi Diabetes Mellitus Tipe 2
Authors: Erdaliza Erdaliza , Mitra Mitra , Rany Novita , Harnani Yessi , Rienarti Abidin Aldiga
Published: December 2024

Diabetes Mellitus Tipe 2 (DM Tipe 2) merupakan penyakit kronis dengan prevalensi yang terus meningkat di Indonesia dan global. Komplikasi DM tipe 2 memberikan dampak serius bagi kualitas hidup penderita. Adanya peningkatan jumlah komplikasi pada pasien DM tipe 2 di RSUD Selasih Kabupaten Pelalawan menjadi permasalahan pada penelitian ini. Tujuan penelitian adalah untuk  mengidentifikasi faktor risiko yang berhubungan dengan komplikasi pada pasien DM tipe 2 di RSUD Selasih Kabupaten Pelalawan.. Desain penelitian yang digunakan adalah kasus kontrol dengan sampel 400 pasien (200 kasus dan 200 kontrol). Kasus adalah pasien DM tipe 2 dengan komplikasi, sedangkan kontrol adalah pasien DM tipe 2 tanpa komplikasi. Sampel kasus dan kontrol diambil menggunakan metode systematic random sampling. Data dikumpulkan melalui rekam medis RSUD Selasih pada Tahun 2023. Analisis data dilakukan melalui uji chi-square dan regresi logistik ganda. Hasil penelitian menunjukkan bahwa kolesterol tinggi (OR=206,46), lama menderita DM (OR=79,62), tekanan darah tinggi (OR=22,54), dan ketidakrutinan kontrol (OR=4,43) secara signifikan berhubungan dengan komplikasi DM tipe 2. Intervensi untuk mengontrol kolesterol, tekanan darah, dan peningkatan rutin kontrol dapat menurunkan risiko komplikasi DM tipe 2. Untuk itu, maka perlu adanya peningkatan edukasi dan program promosi kesehatan dari Rumah Sakit terkait pengelolaan diabetes, sehingga dapat mencegah terjadinya komplikasi DM tipe 2.
ANALYSIS OF POVERTY STRUCTURE IN INDONESIA USING A MULTIFACTORIAL APPROACH
Authors: Pardita Dewa Putu Yudi , Arjawa I Gde Wedana , Paramita Anak Agung Gde Krisna , Setena I Made
Published: December 2024

Poverty is a crucial issue that affects various social and economic aspects in Indonesia, requiring severe attention to achieve sustainable development. This study aims to analyse the impact of economic growth, income distribution, human development index (HDI), government social assistance, and consumption on poverty levels in Indonesia. Using a quantitative research approach with secondary data from Statistics Indonesia for 2019-2023, this study employs panel data regression analysis using EViews 13 to examine the relationship between variables. The findings indicate that economic growth, income distribution, and HDI significantly impact poverty reduction, while government social assistance and consumption do not show a significant influence. These findings imply the need for inclusive economic growth, fairer income distribution, and investments in human capital development. Moreover, there is a need to improve the design of social assistance programs and strategies to promote productive consumption to be more effective in reducing poverty. This highlights the importance of targeted and integrated policies to address poverty in Indonesia comprehensively.JEL: I32, O15, H53.
A transztiretin-amyloidosis specifikus terápiás lehetőségei
Authors: Pozsonyi Zoltán
Published: December 2024

Az elmúlt időszakban látványosan alakult át a szisztémás amyloidosis epidemiológiája. Míg a könnyűlánc-amyloidosis továbbra is ritka, de stabil incidenciájú betegség, a gyulladásos betegségekhez társuló forma (AA) egyre ritkább, a transztiretin-amyloidosis (ATTR) mutációs és vad típusának incidenciája azonban rendkívül megnőtt a fejlett világban. Ezt a látványos növekedést az új, többféle támadópontú gyógyszerek megjelenése okozta fokozódó diagnosztikus éberséggel, valamint az egyszerűbb, könnyebben elérhető diagnosztikai módszerek elterjedésével lehet magyarázni. A közleményben összefoglaljuk a transztiretin-amyloidosis új, specifikus gyógyszeres terápiás lehetőségeit, valamint a közeljövőben várható új kezelési módszereket.
Schedule Optimization for Chemical Library Synthesis
Authors: Ai Qianxiang , Meng Fanwang , Wang Runzhong , Klein J. Cullen , Godfrey Alexander G. , Coley Connor W.
Published: December 2024

Automated chemistry platforms hold the potential to enable large-scale organic synthesis campaigns, such as producing a library of compounds for biological evaluation. The efficiency of such platforms will depend on the schedule according to which the synthesis operations are executed. In this work, we study the scheduling problem for chemical library synthesis, where operations from interdependent synthetic routes are scheduled to minimize the makespan---the total duration of the synthesis campaign. We formalize this problem as a flexible job-shop scheduling problem with chemistry-relevant constraints in the form of a mixed integer linear program (MILP), which we then solve in order to design an optimized schedule. The scheduler's ability to produce valid, optimal schedules is demonstrated by 720 simulated scheduling instances for realistically accessible chemical libraries. Reductions in makespan up to 58%, with an average reduction of 20%, are observed compared to the baseline scheduling approach.
Magnetic carboxylated cellulose nanocrystals for pullulanase immobilization: enhanced enzyme activity and reusability
Authors: Li Yuanpeng , Hou Yi , Luo Shengkai , Hu Songqing
Published: December 2024

In the realm of enzyme immobilization, challenges such as decreased activity post-immobilization and insufficient reusability are frequently encountered. In this paper, carboxylated cellulose nanocrystals (CNCs) obtained from deep eutectic solvent (DES) pretreatment were used for the synthesis of magnetic CNCs (MCNCs), which served as a carrier for enzyme immobilization. The results demonstrated that the hydrophilic carboxyl groups introduced on MCNCs by DES pretreatment are beneficial for enhancing the activity and reusability of immobilized pullulanases. Based on activity and reusability, we further optimized the immobilization conditions and catalytic temperature. Under the optimal conditions, compared to free enzymes, the relative activity of immobilized pullulanase increased to 162.24%, and it maintained 95.07% of its initial activity after 15 cycles of reuse. Overall, our findings highlight the potential of immobilizing pullulanase on MCNC to enhance enzyme activity and reusability.
In-vitro Delivery of Hydrophilic Drugs from Alginate–Montmorillonite Nanocomposite Hydrogels Cross-linked with Multivalent Cations
Authors: Malektaj Haniyeh , D. Drozdov Aleksey , Gurikov Pavel , Schroeter Baldur , Fini Elham , deClaville Christiansen Jesper
Published: December 2024

Alginate hydrogels cross-linked with various cations have numerous applications in targeted drug delivery. To enhance drug encapsulation efficiency, montmorillonite (MMT) clay nanoplatelets are incorporated into the alginate network. This study focuses on the effects of cations (Fe3+, Cu2+, Sr2+, and Ca2+) and concentration of MMT on the kinetics of the in-vitro release of diclofenac sodium from alginate–MMT nanocomposite hydrogels. Drug release is assessed in pH 7 solutions at 37 °C using a UV/Vis spectrophotometer. MMT affects the total drug release differently based on the formation constants of the cations. Drug release data are fitted to a model to identify the release mechanism. The release kinetics for alginate–MMT gels cross-linked with Fe3+ ions differ from those for gels bridged by Cu2+, Sr2+, and Ca2+ ions. Scanning Electron Microscopy analyzes the structural morphology of CO2-supercritical dried gels. Mesh size and diffusion coefficient are calculated from swelling tests. It is found that gel morphology, mesh size, egg-box junction reorganization, and drug release kinetics are strongly affected by the formation constant of cations. This study establishes a correlation between the formation constant and diffusivity, providing a predictive framework for diffusivity across different cations.
Predicting and Explaining Yields with Machine Learning for Carboxylated Azoles and Beyond
Authors: Janssen Kerrin , Proppe Jonny
Published: December 2024

Carbon dioxide can be transformed into valuable chemical building blocks, including C2-carboxylated 1,3-azoles, which have potential applications in pharmaceuticals, cosmetics, and pesticides. However, only a small fraction of the millions of available 1,3-azoles are carboxylated at the C2 position, highlighting significant opportunities for further research in the synthesis and application of these compounds. In this study, we utilized a supervised machine learning approach to predict reaction yields for a dataset of amide-coupled C2-carboxylated 1,3-azoles. To facilitate molecular design, we integrated an interpretable heat-mapping algorithm named PIXIE (Predictive Insights and Xplainability for Informed chemical space Exploration). PIXIE visualizes the influence of molecular substructures on predicted yields by leveraging fingerprint bit importances, providing synthetic chemists with a powerful tool for the rational design of molecules. While heat mapping is an established technique, its integration with a machine-learning model tailored to the chemical space of C2-carboxylated 1,3-azoles represents a significant advancement. This approach not only enables targeted exploration of this underrepresented chemical space, fostering the discovery of new bioactive compounds, but also demonstrates the potential of combining these methods for broader applications in other chemical domains.
Collective Motion of Methylammonium Cations Affects Phase Transition and Self-Trapped Exciton Emission in MAPbI3 Films
Authors: Yeh Chia-Hsun , Cheng Wen-Yu , Chou Tai-Che , Liu Yi-Chun , Chang Chia-Wei , Chen Yu-Sheng , Wang Chih-Hsing , Weng Shih-Chang , Sharp Ian , Chou Pi-Tai , Jiang Chang-Ming
Published: December 2024

Hybrid organic-inorganic halide perovskites are celebrated for their exceptional optoelectronic properties and facile fabrication methods, making them prime candidates for next-generation photovoltaic and optoelectronic devices. However, their inherent instability limits practical applications. To address this, a new class of 3D hollow perovskites, denoted as {en}MAPbI3, has been developed by partially replacing methylammonium (MA+) with ethylenediammonium (en) cations. This study systematically investigates the structural, phase transition, and photophysical properties of {en}MAPbI₃ thin films with varying en content. Incorporating en cations expands the unit cell, suppresses the tetragonal-to-orthorhombic phase transition, and disrupts dipole-dipole interactions among MA⁺ cations. Temperature-dependent photoluminescence (PL) and X-ray diffraction (XRD) reveal that en incorporation stabilizes the tetragonal phase while diminishing the collective rotational dynamics of MA⁺ cations, crucial for phase stability and self-trapped exciton (STE) formation. These insights advance the understanding of 3D hollow perovskites and highlight their potential for stable and tunable optoelectronic applications.
Size-dependent effects of Ge addition on the coking and sintering tendency of PtnGex/alumina (n=4,7,11) model catalysts
Authors: Li Guangjing , Chiu Shawn , Morgan Harry , Fuchs Autumn , Isakov Avital , Poths Patricia , Zhang Zisheng , Alexandrova Anastassia , Anderson Scott
Published: December 2024

The reactivity and adsorbate binding properties of alumina-supported Ptn and PtnGem (n/m = 4/1, 7/2, 11/4) model catalysts were studied using a combination of ethylene and CO temperatureprogrammed desorption (TPD), He+ ion scattering (ISS), and detailed density functional theory (DFT). The Ptn/alumina catalysts gradually deactivated in repeated CO TPD runs and deactivated more rapidly in repeated ethylene TPD runs due to the effects of sintering and carbon deposition (coking). PtnGem/alumina catalysts were dramatically more stable against deactivation by both sintering and coking. Carbon addition to Ptn/alumina also increased stability against sintering, but not coking. Ion scattering was used to probe the nature of adsorbate binding, including the effects of both carbon and Ge addition on the accessibility of strong Pt-associated binding sites for ethylene and CO. DFT was used to examine the electronic and geometric structures and ethylene and CO binding properties of Ptn (n = 4, 7) with added Ge, carbon, or both. Consistent with the ISS results, DFT shows that loss of strong adsorbate binding sites mostly resulted from changes to the electronic properties of the clusters, rather than simple blocking of binding sites by Ge or carbon
Indications for a Direct Singlet Fission Mechanism in TIPS-Pentacene Crystals from Hybrid DFT/MRCI and Molecular Mechanics Studies
Authors: Schulz Timo , Hédé Simon , Marian Christel
Published: December 2024

A hybrid quantum mechanics/molecular mechanics setup was used to model the singlet fission (SF) of electronically excited 6,13-bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene) in the crystalline phase. The optically bright S^bright_1 state possesses nearly identical excitation energies and oscillator strengths in the two nonequivalent dimer units with large and small structural overlap, respectively. A shearing/tilting motion of the two slip-stacked TIPS-pentacene building blocks is the key for stabilizing the singlet-coupled triplet-pair state, ^1(TT), in the large/small overlap situation. In both dimer models, the S^bright_1 and ^1(TT) states swap energetic order upon geometry relaxation, indicative of strong nonadiabatic coupling between these states and a direct SF mechanism in TIPS-pentacene crystals, at variance with unsubstituted pentacene. The overall energy balance E(S^bright_1 ) -(E(T_1)+E(T_1)) remains positive at all investigated nuclear arrangements. Charge-transfer states and the ferromagnetically coupled ^5(TT) state lie energetically too high for taking part in the SF mechanism.
PRINTING ARABIC BOOKS IN EUROPE 1475 – 1710
Authors: Waisy Karwan
Published: December 2024

This period of printing and translating Arabic books in Europe (1475-1710) is considered as a “significant and preliminary phase” of printing books in Arabic language in Europe. Hence, this article is allocated to depict the printing books in Arabic language process. This article pays a great attention to the written language of Quran and Arabic grammar in Europe. This subject is been regularly ignored, and Kurdish academic institutions have begun to pay attention to it. As a result, this research attempts to clarify some historical development and new assessment of i. This study has taken most attention to the printing process, types of printings, and other aspects of it. The article uses some key articles and reports, which are published in English language. The objective of this research is to show the most important Arabic books that have been printed in Europe and the European aims of printing these books. Most of the Arabic books printed by Europeans were related to Islam and Arabic grammar. This raises key questions why European paid most attention to the printing and translating Arabic accounts. According to this premise, this research aims to answer some crucial questions that are related to this study, such as: Why the European paid most attention to printing and translating Arabic books?  What subjects and issues were these books related to? Were Europeans seeking to benefit from those books, or were they attempting to critique Islam and the Arabic language? Did the printing and translating Arabic books have effects on the emergence of ideas in the Arabic World?
Digital Arms for Digital Consumer Harms - Mapping Legal and Technical Solutions for Dark Patterns in EU Consumer Law
Authors:   Maastricht University, Roșca Constanța ,   Leiden University
Published: December 2024

Since 2010, technologists have warned about online businesses using dark patterns—designs that may behaviorally manipulate consumers—in user interfaces.

This book tunes into the academic debate on regulating dark patterns in EU consumer protection law. It connects it with discussions on technology regulation in law and technology scholarship to map policy solutions.

It also draws on web measurement literature to explore the technical feasibility of computationally detecting unlawful dark patterns to improve digital market enforcement. This exercise challenges policy and academic preferences for technology-neutral regulation by showing how technology neutrality may hinder the design of compliant user interfaces and the development of computational methods for digital enforcement. Its findings and recommendations are relevant to academics, policymakers, and enforcement authorities.
Chapter 2. A primer on web development and design
Authors:   Maastricht University, Roșca Constanța ,   Leiden University
Published: December 2024

E-commerce is rapidly growing and is expected to reach $4.45 trillion in revenue by 2024, with online stores being the primary sales channel. To succeed, retailers need to optimize user experience on their websites, as poor design can lead to lost sales. Big companies like Amazon lead the market by continuously innovating and testing website features to improve customer satisfaction.
Chapter 9. Summary of conclusions and final remarks
Authors:   Maastricht University, Roșca Constanța ,   Leiden University
Published: December 2024

This chapter discusses the need to better regulate dark patterns in digital markets to protect consumers. It argues that technology-specific rules may be more effective than general regulations, as they can address the unique challenges posed by these practices. The author suggests that automated detection methods could help enforce compliance and adapt to the changing digital landscape.
The Effect of Health Education on Low Fat Diets through Video Media on Knowledge Level in Cholesterol Sufferers
Authors: Retnosari Merlina , Yuniartika Wachidah
Published: December 2024

Hypercholesterolemia is still a health problem that can lead to complications such as hypertension, coronary heart disease, and stroke, but it can be controlled by modifying lifestyle. Health education in the form of video media counseling can be done to increase knowledge and awareness to change one's behavior. This study aimed to determine the effect of health education on a low-fat diet through video media on the level of knowledge. This study used a quasi-experiment with a one-group pre and post-test design. The sample used was 33 respondents using the purposive sampling technique. The research was conducted from June to July 2024. Using the Dyslipidemia Dietary Knowledge Questionnaire (DDKQ), which was developed, the results of corrected item-total correction >0.632 with Cronbach's alpha >0.60, namely 0.941. Inclusion criteria are the results of checking cholesterol levels before giving intervention (200mg/dl), willingness to be a respondent, the category of knowledge is less and enough, can do activities independently, and has a cellphone. Exclusion criteria have comorbidities and do not follow the flow of research until the end. Data analysis using univariate analysis and the Wilcoxon signed rank test. Based on the Wilcoxon Signed Ranks test results, the p-value is 0.001, which is <0.05. There is an effect of health education on a low-fat diet through videos on the level of knowledge in cholesterol sufferers.
НАПРЯМИ СУЧАСНИХ ДОСЛІДЖЕНЬ У СПОРТИВНОМУ ТАНЦІ, СПРЯМОВАНІ НА ФОРМУВАННЯ СТРУКТУРИ СПЕЦІАЛЬНОЇ ПІДГОТОВЛЕНОСТІ СПОРТСМЕНІВ ВИСОКОГО КЛАСУ
Authors: Соронович І. М. , Коросташов Д. Д. , Галай Я. С.
Published: December 2024

Актуальність. Сучасна система наукових досліджень в спортивному танці є природнім продовження фундаментальних і прикладних досліджень теорії спорту, прикладної біології, психології, біомеханіки спорту. Систематизація даних класичної і сучасної літератури проведено відповідно цільовим настановам підготовки спортсменів в спортивному танці. Мета. Сформувати передумови і визначити шляхи вдосконалення тренувального процесу спортсменів високого класу в спортивному танці. Методи. Мета-аналіз класичної і сучасної літератури з теорії спорту, науково-методичних основ підготовки спортсменів-танцюристів, біології спорту. Результати. В роботі розглянуті фактори забезпечення і реалізації змагальної діяльності спортсменів-танцюристів, які визначені за узагальненими критеріями теорії спорту В. Платонова, 2020 [12] і теорії танцювального спорту M. Wyon, G. Allard, 2022 [56], розкриті і модифіковані відповідно сучасними тенденціями розвитку виду спорту. Згідно з даними спеціалістів до факторів забезпечення відносять характеристики нейродинамічних функцій, реактивних властивостей КРС, опорно-рухового апарату, специфічні прояви силових можливостей і енергозабезпечення, які формують структурні компоненти функціонального забезпечення змагальної діяльності – швидку кінетику, стійкий стан функцій, компенсацію втоми. До факторів реалізації відносять – артистичну і хореографічну майстерність, ментальні (психологічні) чинники. Висновки. Механізмом вдосконалення змагальної діяльності є інтеграція технічної, фізичної, артистичної і хореографічної підготовки в структури забезпечення і реалізації змагальної діяльності, підґрунтям інтеграційних процесів є функціональне забезпечення спеціальної працездатності спортсменів з урахуванням кількісних і якісних характеристик стандартної європейської і латиноамериканської програми змагань, специфічних характеристик підготовленості партнерів і партнерок.
Fantasia Melengking
Authors: Alpan Deny , Sidik Hadaci , Surayya Yade , Adha Yasril , Hendri Yon
Published: December 2024

Seni bertutur atau sering dikenal dengan sastra lisan merupakan satu diantara wujud ekpresi dari Masyarakat. seni bertutur yang tumbuh dan berkembang di Desa Mudung Darat, Kab. Muaro Jambi, yaitu Jolo Mudung. Jolo memiliki makna sebuah nyanyian, sedangkan Mudung merupakan nama sebuah desa. Seni bertutur Jolo Mudung berisikan pantun yang sesuai dengan konteks yang terjadi pada masyarakat. Metode dalam penggarapan karya ini menggunakan: persiapan, tahap proses penciptaan. Hasil penggarapan ini yaitu Jolo mudung adalah sebuah komposisi musik yang terbagi dalam 2 bagian. Komposisi musik Melengking berangkat dari lantunan sahutan Jolo Mudung , yang menggembangkan melodi sahutan Jolo Mudung diwujudkan menjadi sebuah komposisi musik dengan format World musik serta bentuk musik Fantasia.
Changes in The Use Of Gending Kebo Giro To Hadrah Shalawat Nabi Mahallul Qiyam In Temu Manten Tradition in Bumi Mulya Kuantan Singingi Regency Riau Province
Authors: Sari Renita , Sriwulan Wilma , Awerman Awerman , Wijaksana Bambang
Published: December 2024

Temu Manten is a tradition in the traditional Javanese wedding procession. Temu Manten in Javanese means bring together bride and groom at the bride's residence in a part of traditional wedding processions. When the Temu Manten procession takes place, used Gending Kebo Giro as a music accompaniment at Temu Manten tradition. Gending Kebo Giro is played starting from the beginning of the procession until the Temu Manten tradition ends. Over time, the Temu Manten tradition in Bumi Mulya has undergone several significant changes, one of which is the change of musical accompaniment to the Temu Manten procession. Musical accompaniment which usually uses Gending Kebo Giro is currently replaced by Hadrah Sholawat Nabi Mahalul Qiyam. This study uses a qualitative research method using ethnography as a  approach. Data collection was carried out through literature study, observation, and interviews. Through the theory of change by Gerth and Mills as the main theory, the research results show that: changes in the use of gending to hadrah are caused by several factors including inter-ethnic marriage, the influence of Malay culture, and reasons for spending much amount of material.
Application possibilities of marketing strategy in construction companies
Authors: Bashar Habib oglu Shirinov , Ilkin Farid oglu Mammadzade
Published: December 2024

The purpose of the analysis of the socio-economic environment is to determine the social and socio-economic aspects related to the development and evaluation of the project strategy and marketing concept. These aspects can reflect the society and its culture, social and economic situation, politics in the regions, as well as existing rules, traditions and customs, etc. The scope and depth of marketing research is determined by the complexity or novelty of the research. Determining the appropriate methods and means of conducting marketing research should be consistent with the objectives and limitations. A fairly important point in conducting research is the assessment of necessary and sufficient information. Since the collection of information itself has a high cost in the modern economy, its collection process requires adequate management. An external and internal analysis should be carried out in each specific project, but the base set, as a rule, remains the same. Market structure analysis is usually the identification and quantification of different market segments. At the same time, there are many models for the analysis of market segments, which are a combination of different criteria or directions for segmentation, market (structuring). Such criteria can be consumer segmentation: - with the benefit obtained from the use of the product; - through life; - gender and age; - geographic; - about the situations of consumers; - according to the rules (strategies) for the selection of goods; - brand loyalty; - due to price sensitivity; - using the classifiers of the sectors of the national economy; - according to the way you shop. Analysis of market capacity is aimed at predicting potential sales realistically in a certain place, determining the goods sold. When analyzing market capacity, it is very important to identify and account for seasonal or other fluctuations in sales. In our opinion, when choosing a strategy for the development of construction enterprises, it is necessary to be guided by a system of objective preconditions for the formulation of the main strategies, because real success depends not only on the rational organization of production, cost, but also on the reduction, resource efficiency, increase in labor productivity and other organizational and production factors, but also from the ability to adapt to the external environment, the needs of consumers, the competition of commodity producers, distribution channels and the movement of goods, ie. it also depends on the marketing strategy.
Comparison of Structural Response Utilizing Probabilistic Seismic Hazard Analysis and Design Spectral Ground Motion
Authors: Pranowo . , Makrup Lalu , Pawirodikromo Widodo , Muntafi Yunalia
Published: December 2024

Indonesia is seismically active due to tectonic plate convergence south of Java Island. In the examination of earthquake-resistant structures, Indonesia possesses the SNI 1726-2019 rule; however, it requires re-evaluation in conjunction with other seismic motions, specifically the PSHA method. The PSHA approach is employed in probability-based seismic hazard analysis, taking into account uncertainties related to earthquake magnitude, location, and frequency to provide a comprehensive assessment of a location's hazard level. To demonstrate the impact of ground motion induced by earthquakes on structural reaction, it is essential to study the structure using the time history of SNI and PSHA artificial earthquake shaking. Spectrum matching with target spectra derived from probabilistic seismic hazard analysis can build artificial time histories. Consequently, the time history obtained from the analysis can be considered to be derived from the probabilistic methodology. Both analytical methods, SNI and PSHA, indicate that the structural reaction of the Alana Hotel is not markedly different, and the structure remains secure against seismic activity. Doi: 10.28991/CEJ-SP2024-010-012 Full Text: PDF