bluuebunny/crossref_metadata_2025 huggingface dataset:
Empfehlungen für die Erstellung von Hitzeaktionsplänen – Handeln für eine bessere Gesundheitsvorsorge
Authors: Mücke Hans-Guido , Straff Wolfgang
Published: March 2020

Als Effekt des Klimawandels stellen extreme Hitzeereignisse eine zunehmende Gesundheitsgefährdung dar. Hitzeaktionspläne dienen der Etablierung gezielter Interventionsmaßnahmen zum präventiven Gesundheitsschutz. Hierzu wurden 2017 Handlungsempfehlungen publiziert. Sie skizzieren kurz-, mittel- und langfristige Optionen für gesundheitliche Anpassungsmaßnahmen an den Klimawandel für eine zeitnahe Umsetzung regional bzw. lokal angepasster Hitzeaktionspläne.
Sharing SRP data to reduce environmentally associated disease and promote transdisciplinary research
Authors: Heacock Michelle L. , Amolegbe Sara M. , Skalla Lesley A. , Trottier Brittany A. , Carlin Danielle J. , Henry Heather F. , Lopez Adeline R. , Duncan Christopher G. , Lawler Cindy P. , Balshaw David M. , Suk William A.
Published: March 2020

The National Institute of Environmental Health Sciences (NIEHS) Superfund Basic Research and Training Program (SRP) funds a wide range of projects that span biomedical, environmental sciences, and engineering research and generate a wealth of data resulting from hypothesis-driven research projects. Combining or integrating these diverse data offers an opportunity to uncover new scientific connections that can be used to gain a more comprehensive understanding of the interplay between exposures and health. Integrating and reusing data generated from individual research projects within the program requires harmonization of data workflows, ensuring consistent and robust practices in data stewardship, and embracing data sharing from the onset of data collection and analysis. We describe opportunities to leverage data within the SRP and current SRP efforts to advance data sharing and reuse, including by developing an SRP dataset library and fostering data integration through Data Management and Analysis Cores. We also discuss opportunities to improve public health by identifying parallels in the data captured from health and engineering research, layering data streams for a more comprehensive picture of exposures and disease, and using existing SRP research infrastructure to facilitate and foster data sharing. Importantly, we point out that while the SRP is in a unique position to exploit these opportunities, they can be employed across environmental health research. SRP research teams, which comprise cross-disciplinary scientists focused on similar research questions, are well positioned to use data to leverage previous findings and accelerate the pace of research. Incorporating data streams from different disciplines addressing similar questions can provide a broader understanding and uncover the answers to complex and discrete research questions.
Fingolimod Rescues Demyelination in a Mouse Model of Krabbe's Disease
Authors: Béchet Sibylle , O'Sullivan Sinead A. , Yssel Justin , Fagan Steven G. , Dev Kumlesh K.
Published: March 2020

Krabbe's disease is an infantile neurodegenerative disease, which is affected by mutations in the lysosomal enzyme galactocerebrosidase, leading to the accumulation of its metabolite psychosine. We have shown previously that the S1P receptor agonist fingolimod (FTY720) attenuates psychosine-induced glial cell death and demyelination bothin vitroandex vivomodels. These data, together with a lack of therapies for Krabbe's disease, prompted the current preclinical study examining the effects of fingolimod in twitcher mice, a murine model of Krabbe's disease. Twitcher mice, both male and female, carrying a natural mutation in the galc gene were given fingolimod via drinking water (1 mg/kg/d). The direct impact of fingolimod administration was assessed via histochemical and biochemical analysis using markers of myelin, astrocytes, microglia, neurons, globoid cells, and immune cells. The effects of fingolimod on twitching behavior and life span were also demonstrated. Our results show that treatment of twitcher mice with fingolimod significantly rescued myelin levels compared with vehicle-treated animals and also regulated astrocyte and microglial reactivity. Furthermore, nonphosphorylated neurofilament levels were decreased, indicating neuroprotective and neurorestorative processes. These protective effects of fingolimod on twitcher mice brain pathology was reflected by an increased life span of fingolimod-treated twitcher mice. Thesein vivofindings corroborate initialin vitrostudies and highlight the potential use of S1P receptors as drug targets for treatment of Krabbe's disease.

SIGNIFICANCE STATEMENTThis study demonstrates that the administration of the therapy known as fingolimod in a mouse model of Krabbe's disease (namely, the twitcher mouse model) significantly rescues myelin levels. Further, the drug fingolimod also regulates the reactivity of glial cells, astrocytes and microglia, in this mouse model. These protective effects of fingolimod result in an increased life span of twitcher mice.
THE USE OF THE “DESIGN-THINKING” AND “SEVEN HATS” METHODSAT THE PROJECT INITIATION AND PLANNING STAGE
Authors: Kolesnikov Olexii E. , Lukianov Dmytro V. , Gogunskii Viktor D. , Sherstyuk Olga I.
Published: March 2020

The article is devoted to the comparison of tools for analyzing innovative ideas, such as “design thinking” and the modified “seven hats” method. Both methods are actively used in project management at the initiation and planning stages. Thetechnology of generation, analysis and selection of creative ideas of projects based on the combination of these two approaches when working in a team is considered. The article is a continuation of the authors' research in the field of creative thinking prob-lems, both in the field of education, and in the field of professional project and program management. The results can be used to develop a theoretical framework for project management at the stage of generating ideas and initiating projects.The logic of the process approach of the design-thinking method echoes the logic of using the modified seven hats method. Therefore, the authors propose to use in the work of project teams at the stage of project initiation a modified “seven hats”method together with the “design-thinking” method. At the stageof consideration of the project idea, it is proposed to approach the devel-opment of the idea step by step, since this is required by the “design-thinking” method, and at each stage all team members wear the same “hats”. The paper presents the methodology obtained by directly transferring the methods and tools proposed for the “seven hats” method in the logic of their consistent use in conjunction with the “design thinking” technique. A table has been developed for the correspondence of the stages of creating a project idea using the “design thinking” and “seven hats” approaches, for example, the “green hat” is assigned to the “generating ideas” stage, and the “blue”, “white” and “black” hats to the “prototype testing” phase. Developing the ideas of Edward de Bono, it becomes possible not only to effectively generate ideas at the stage of project initiation, but also to develop prototypes that have the value the customer needs. Namely, this is the result of a successfulproject activity.
3D VECTOR FIELDS VISUALIZATION USING GRAPHICS PROCESSING UNITS
Authors: Romanyuk Olexandr N. , Vyatkin Sergey I. , Antoshchuk Svitlana G.
Published: March 2020

The paper describes a method of visualization of three-dimensional vector fields adapted for GPUs. The aim of this work is to develop and implement a method of visualization of three-dimensional vector fields, effectively using GPUs. The software for visualization of three-dimensional vector field based on algorithms developed by the authors is created. This application provides visualization of three-dimensional vector fields through an interactively controlled animation sequence. The main criteria for evaluating the performance of visualization algorithms are the ease of interpretation and performance. The paper deals with the problems of adaptation of the computational model of vector field visualization algorithms to the implementation based on the GPU. Effective data representation for methods implemented based on vertex and pixel shaders of graphic processors is developed. The generalized model of calculations based on the graphic processor is offered. The program for interactive visualization of sections of a three-dimensional field of speeds by means of animation is created. A method of decomposition of a three-dimensional texture cube to represent a three-dimensional vector field is developed. All proposed algorithms are implemented in the form of software modules that can be used to build a visualization system. This paper describes a method of ray casting for visualizing three-dimensional vector fields. The distinguishing features of this method are the separation of the screen into cells (spans) and the pipelining of calculations using an intermediate description of the frame in the form of a list of primitives. Splitting calculations into two phases using an intermediate frame description allows achieving maximum performance at the stage of pixel calculations that require the most resources and determine the performance of the system as a whole. The advantages of such an approach over the frame-buffer visualization method are shown. The use of modern graphics equipment allows achieving the best results in terms of performance. Three-dimensional vector fields are used in scientific visualization, image processing and for special effects.
PREDICTING OF SPORTS EVENTS RESULTS
Authors: Zhdanova Olena G. , Romanchenko Bohdan V. , Sperkach Maiia O.
Published: March 2020

Today, the field ofbetting and bookmaking is popular with a wide range of sports fans. Issues of predicting the outcome of future events are and will be relevant for everyday life, sports, politics, etc. With the increasing number and quality of methods of intellectual analysis, the idea of predicting the results of sporting events became feasible. Applying different mathematical methods helps to obtain more accurate predictions of results than subjective expert estimates. The paper introduces the concept of betting and describes in general terms the task of bookmaking. The purpose of the study and the tasks that must be accomplished to achieve the goal are identified. Existing research results of different scientists who have researched this problem are analyzed. There arefour basic principles for predicting the outcome of sports events. Different approaches to the task have been considered and our own way of solving it has been proposed. Methods such as Poisson distribution, simulation modeling of the Markov Monte Carlo chain, and many other research methods have been considered. The formulation of the problem is formulated and the properties of the problem are investigated. A backtesting algorithm was developed and described as a mechanism for presenting team statistics at any point in time for a particular season to collect sports event data. Correlation analysis for the selected parameters was shown to show a moderate correlation of data and the use of Google AutoML to identify patterns between the data was described. The importance of using machine learning to solve this problem is outlined. A system has been developed that collects event data and calculates statistics for each team at each point of time using the backtesting algorithm. A service has been developed to create and test the quality of the strategy. The results of experimental studies of task efficiency are presented, where we conducted experimental sets of strategies with and without adding the result of the AutoML service and for each strategy the Pearson correlation coefficient was calculated based on the results of two past seasons. The results obtained are analyzed.
18F-FDOPA PET/CT accurately identifies MEN1-associated pheochromocytoma
Authors: Tepede Aisha A , Welch James , Lee Maya , Mandl Adel , Agarwal Sunita K , Nilubol Naris , Patel Dhaval , Cochran Craig , Simonds William F , Weinstein Lee S , Jha Abhishek , Millo Corina , Pacak Karel , Blau Jenny E
Published: March 2020

Pheochromocytoma (PHEO) in multiple endocrine neoplasia type 1 (MEN1) is extremely rare. The incidence is reported as less than 2%. We report a case of a 76-year-old male with familial MEN1 who was found to have unilateral PHEO. Although the patient was normotensive and asymptomatic, routine screening imaging with CT demonstrated bilateral adrenal masses. The left adrenal mass grew from 2.5 to 3.9 cm over 4 years with attenuation values of 9 Hounsfield units (HU) pre-contrast and 15 HU post-contrast washout. Laboratory evaluation demonstrated an adrenergic biochemical phenotype. Both 18F-fluorodeoxyglucose (18F-FDG) PET/CT and 123I-metaiodobenzylguanidine (123I-mIBG) scintigraphy demonstrated bilateral adrenal uptake. In contrast, 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT demonstrated unilateral left adrenal uptake (28.7 standardized uptake value (SUV)) and physiologic right adrenal uptake. The patient underwent an uneventful left adrenalectomy with pathology consistent for PHEO. Post-operatively, he had biochemical normalization. A review of the literature suggests that adrenal tumors >2 cm may be at higher risk for pheochromocytoma in patients with MEN1. Despite a lack of symptoms related to catecholamine excess, enlarging adrenal nodules should be biochemically screened for PHEO. 18F-FDOPA PET/CT may be beneficial for localization in these patients.

Learning points:

18F-FDOPA PET/CT is a beneficial imaging modality for identifying pheochromocytoma in MEN1 patients.

Adrenal adenomas should undergo routine biochemical workup for PHEO in MEN1 and can have serious peri-operative complications if not recognized, given that MEN1 patients undergo frequent surgical interventions.

MEN1 is implicated in the tumorigenesis of PHEO in this patient.
Integrated analysis of mRNA and protein expression profiling in tubal endometriosis
Authors: Qi Hang , Zhang Huiyu , Zhao Xiaoya , Qin Ya , Liang Guiling , He Xiaoqing , Zhang Jian
Published: March 2020

Tubal endometriosis (tubal EM) is a subtype of endometriosis (EM) associated with fallopian tube impairments and infertility. Since the molecular mechanism underlying tubal EM is not clear, we assume that an aberrant transcriptome of fallopian tube epithelium and microenvironment changes caused by cytokines in tubal fluid are possible causes. The aim of this study was to identify potential hub mRNAs/proteins of tubal EM through integrated transcriptomic and proteomic analyses and to elucidate significant pathways, cellular functions, and interaction networks during the initiation and progression of tubal EM. We obtained human fallopian tube epithelium and tubal fluid samples from patients with and without tubal EM. Tubal epithelia were analyzed using microarray, and tubal fluid was analyzed using quantitative label-free LC-MS/MS. We identified differentially expressed genes (DEGs) and differentially expressed proteins (DEPs) and determined common mRNAs/protein. We observed 35 commonly deregulated mRNAs/proteins, and IPA indicated that cellular movement, inflammatory response, and immune cell trafficking were significantly activated during the pathogenesis of tubal EM. We also identified acute phase response signaling pathway activation as a unique pathogenesis signature of tubal EM. Our results demonstrate that an integrated analysis of the transcriptome and proteome has the potential to reveal novel disease mechanisms at a molecular level.
Cas9-Mediated Gene-Editing in the Malaria Mosquito Anopheles stephensi by ReMOT Control
Authors: Macias Vanessa M. , McKeand Sage , Chaverra-Rodriguez Duverney , Hughes Grant L. , Fazekas Aniko , Pujhari Sujit , Jasinskiene Nijole , James Anthony A. , Rasgon Jason L.
Published: March 2020

Innovative tools are essential for advancing malaria control and depend on an understanding of molecular mechanisms governing transmission of malaria parasites by Anopheles mosquitoes. CRISPR/Cas9-based gene disruption is a powerful method to uncover underlying biology of vector-pathogen interactions and can itself form the basis of mosquito control strategies. However, embryo injection methods used to genetically manipulate mosquitoes (especially Anopheles) are difficult and inefficient, particularly for non-specialist laboratories. Here, we adapted the ReMOT Control (Receptor-mediated Ovary Transduction of Cargo) technique to deliver Cas9 ribonucleoprotein complex to adult mosquito ovaries, generating targeted and heritable mutations in the malaria vector Anopheles stephensi without injecting embryos. In Anopheles, ReMOT Control gene editing was as efficient as standard embryo injections. The application of ReMOT Control to Anopheles opens the power of CRISPR/Cas9 methods to malaria laboratories that lack the equipment or expertise to perform embryo injections and establishes the flexibility of ReMOT Control for diverse mosquito species.
Respiratory Support During Pulmonary Artery Thromboembolia (Review)
Authors: Ostapchenko D. A. , Gutnikov A. I. , Rubanova D. V. , Losev A. A.
Published: March 2020

Pulmonary artery thromboembolia (PATE) is not a clinical entity as such, but a complication of diﬀerent diseases and conditions leading to deep thrombosis in the low tension circulation system, right cardiac chambers or causing local thrombosis in the pulmonary artery system. PATE is characterized by complex pathogenesis of respiratory failure of varying severity, which makes it diﬃcult to choose a respiratory support technique.

Purpose of the overview: to show advantages of diﬀerent respiratory support techniques and prospects of high-ﬂux oxygen therapy with regard to PATE pathophysiology.

82 sources were selected based on the principle of combining clinical and experimental data from papers published over the recent 5 years and earlier that are still relevant for medical practice.

The overview presents the structure of main causes and prevalence of PATE and considers thrombogenesis stages and predominant manifestations of respiratory failure during PATE occurring due to inconsistency be

tween pulmonary ventilation and perfusion. Review discusses ﬁve methods of respiratory therapy in PATE patients: low-ﬂux and high-ﬂux oxygen therapy, non-invasive and invasive artiﬁcial lung ventilation, extracorporeal blood oxygenation. Finally, the paper shows the eﬃcacy and limitations of these methods.

Conclusion. High-ﬂux oxygen therapy seems to be the most eﬀective and promising technique in PATE patients thanks to absence of adverse cardiohemodynamic consequences, subjective comfort for patients, and relation to minimal risks of secondary infectious complications.

Nevertheless, the clinical experience accumulated is insuﬃcient to make an absolute choice of one particular technique for respiratory support during PATE. It is necessary to continue investigating the clinical eﬃcacy of high-ﬂux oxygen therapy in the speciﬁc population of patients who experienced PATE.
FEASIBILITY OF RESPIRATORY SYSTEM MODULE BASED ON CREATIVE PROBLEM SOLVING LEARNING MODEL WITH MIND MAPPING TO EMPOWER PROBLEM SOLVING SKILLS
Authors: Sugiyanto Fadilah Nur , Masykuri Mohammad , Muzzazinah Muzzazinah
Published: March 2020

KELAYAKAN MODUL SISTEM PERNAPASAN BERBASIS CREATIVE PROBLEM SOLVING DISERTAI MIND MAPPING UNTUK MEMBERDAYAKAN KETERAMPILAN PEMECAHAN MASALAH        AbstractThe aim of this research is to describe the feasibility of respiratory system module based on Creative Problem Solving learning model with mind mapping to empower problem solving skill. This research was a research and development by using descriptive percentage technique. The feasibility of module is tested through a validation stage by a team of experts, practitioners, and students. Validation results by experts’ show, respiratory system module expressed in appropriate criteria and very good category. This result is supported by the results of the appraisement of practitioners and students with an average grade on very good category. The results indicate that the respiratory system module is worthy can be used to empower problem solving skills.AbstrakPenelitian ini bertujuan mendeskripsikan kelayakan modul sistem pernapasan berbasis model pembelajaran Creative Problem Solving disertai mind mapping untuk memberdayakan keterampilan pemecahan masalah. Penelitian ini merupakan penelitian Research & Develompment (R&D) dengan menggunakan teknik deskriptif persentase. Hasil validasi modul sistem pernapasan oleh ahli dengan kriteria layak dan dengan kategori sangat baik. Hasil tersebut didukung oleh hasil penilaian praktisi pendidikan dan siswa, dengan kategori nilai rata-rata sangat baik. Hasil ini mengindikasi bahwa modul sistem pernapasan hasil pengembangan layak digunakan untuk memberdayakan keterampilan pemecahan masalah.kurang, 15% dengan kategori kurang, 3% dengan kategori baik, dan 27% dengan kategori sangat baik.
THE CONTRIBUTION OF CONTENT, PEDAGOGY, AND TECHNOLOGY ON THE FORMATION OF SCIENCE TEACHERS’ TPACK ABILITY
Authors: Yulisman Hendra , Widodo Ari , Riandi Riandi , Nurina Cut Intan Evtia
Published: March 2020

KONTRIBUSI PENGETAHUAN KONTEN, PEDAGOGI, DAN TEKNOLOGI TERHADAP PEMBENTUKAN TPACK GURU IPA AbstrakModel integrasi teknologi mengalami perubahan dari model yang berfokus pada teknologi ke model yang berfokus pada pedagogi, salah satunya adalah TPACK. Informasi mengenai kemampuan TPACK guru IPA dan kontribusi pengetahuan konten, pedagogi, dan teknologi dalam pembentukan TPACK guru masih belum banyak tersedia. Oleh sebab itu, penelitian ini bertujuan untuk memperoleh informasi mengenai kemampuan TPACK guru IPA dan kontribusi pengetahuan konten, pedagogi, dan teknologi dalam pembentukan TPACK. Penelitian survei ini melibatkan 88 orang guru mata pelajaran IPA Kota Banda Aceh. Data mengenai kemampuan TPACK guru diperoleh dari soal tes berbentuk pilihan berganda. Penyebaran soal dilakukan secara langsung melalui kegiatan pelatihan. Analisis data dilakukan secara statistik deskriptif dan inferensial (pemodelan SEM-PLS). Hasil penelitian menunjukkan bahwa profil kemampuan TPACK guru IPA SMP di Kota Banda Aceh didominasi oleh  pengetahuan konten (CK). Hasil analisis SEM-PLS menunjukkan bahwa CK, PK, dan PCK secara langsung dan tidak langsung berkontribusi dalam pembentukan TPACK guru IPA SMP di Kota Banda Aceh. Pemerintah dan penyelenggara pendidikan diharapkan dapat membantu guru untuk meningkatkan kemampuan menggunakan teknologi secara efektif dalam kegiatan pembelajaran agar terbentuk TPACK yang komprehensif.AbstractThe model of technology integration has changed from models that focus on technology to models that focus on pedagogy, one of which is TPACK. The information about science teachers’ TPACK and the contribution of content, pedagogy, and technology on the formation of science teachers’ TPACK is still limited. Therefore, this research aimed to obtain information about the science teachers’ TPACK and the contribution of content, pedagogy, and technology on the formation of TPACK. This survey research involved 88 science teachers from Banda Aceh City. The data about science teachers’ TPACK was obtained from multiple-choice test questions. The questions were distributed directly through training activities. Data analysis was performed by descriptive and inferential statistics (SEM-PLS modeling). The results showed that the TPACK ability profile of junior high school science teachers in Banda Aceh City was dominated by content knowledge (CK). The results of the SEM-PLS analysis showed that CK, PK, and PCK, directly and indirectly, contributed to the formation of the science teachers’ TPACK in junior high school in Banda Aceh City. The government and education providers were expected to be able to help teachers to improve the ability to use technology effectively in learning activities to form a comprehensive TPACK.
EFEKTIFITAS PELATIHAN LABORATORIUM VIRTUAL SEBAGAI MEDIA PEMBELAJARAN BAGI GURU KIMIA
Authors: Lutfi Achmad , Sukarmin Sukarmin
Published: March 2020

EFFECTIVITY OF VIRTUAL LABORATORY TRAINING AS A LEARNING MEDIA FOR CHEMISTRY TEACHERSAchmad Lutfi, SukarminUniversitas Negeri Surabaya, Indonesia achmadlutfi@unesa.ac.idAbstractThe study aims to determine the level of training achievement using virtual laboratories for chemistry teachers on the ability of teachers to use virtual laboratories and the achievement of objectives in learning chemistry using virtual laboratories. The training was conducted for chemistry teachers who were members of the City and District High School Chemistry Teachers' Working Group (MGMP). During the study, the teachers were trained in how to install, operate virtual laboratories, and conduct experiments with virtual laboratories. At the end of the activity, an ability test was conducted using a virtual laboratory, giving questionnaires to participants and assigning participant assignments in the form of lesson plans (RPP) with the use of virtual laboratories as learning media. The data obtained showed that 90% of the participating teachers had been able to use virtual laboratory programs, including installing, operating, and conducting experiments with virtual laboratories. 82-100% of the participants found it useful to participate in the activities, and the compiled lesson plans showed that the participants were able to use the virtual laboratory as a medium for chemistry learning with a percentage of 85% -100%, and students gave positive responses and good learning outcomes after participating in chemistry learning with use of virtual laboratories. AbstrakPenelitian bertujuan mengetahui tingkat ketercapaian pelatihan menggunakan laboratorium virtual bagi guru kimia terhadap kemampuan guru menggunakan laboratorium virtual dan ketercapaian pembelajaran kimia dengan menggunakan laboratorium virtual. Pelatihan dilakukan terhadap guru kimia yang tergabung pada Musyawarah Guru Mata Pelajaran Kimia Sekolah Menengah Atas  Kota dan Kabupaten Kediri. Selama penelitian dilatihkan cara menginstal , mengoperasikan laboratorium virtual dan melakukan percobaan dengan laboratorium virtual. Pada akhir kegiatan dilakukan tes kemampuan menggunakan laboratorium virtual, pemberian angket kepada peserta dan pemberian tugas peserta berupa pembuatan rencana pelaksanaan pembelajaran (RPP) dengan pemanfaatan laboratorium virtual sebagai media pembelajaran. Data yang diperoleh menunjukkan 90% guru peserta telah mampu menggunakan program laboratorium virtual, meliputi: menginstal, mengoperasikan, dan melakukan percobaan dengan laboratotium virtual. Sebesar 82-100 % peserta merasa bermanfaat mengikuti kegiatan dan RPP yang disusun memperlihatkan bahwa peserta sudah dapat memanfaatkan laboratorium virtual sebagai media pembelajaran kimia dengan prosentasi  85%-100%, serta peserta didik memberikan tanggapan positif dan hasil belajar yang baik setelah mengikuti  pembelajaran kimia dengan penggunaan laboratorium virtual.
PENINGKATAN KEMAMPUAN PEMECAHAN MASALAH FISIKA DENGAN MODEL PEMBELAJARAN INQUIRY-DISCOVERY
Authors: Wartono Wartono , Batlolona John Rafafy , Mahfi Rizqi Maulidina
Published: March 2020

ENHANCEMENT OF PHYSICS PROBLEM-SOLVING SKILLS WITH INQUIRY-DISCOVERY LEARNING MODEL AbstractThe purpose of this study was to determine differences in problem solving abilities of students who were given inquiry-discovery learning through web-assisted empirical-theoretical reviews with students who were given conventional learning. This study uses a quasi-experimental pretest-posttest control group design. The average gain score of the problem solving ability test shows that students who are taught with inquiry-discovery learning through web-assisted empirical-theoretical reviews are higher than students who are taught with conventional learning. Hypothesis test results show that students who are learning with inquiry-discovery learning through web-assisted empirical-theoretical reviews have higher problem solving abilities than students who are taught with conventional learning, this also applies to students with high or low initial abilities. AbstrakTujuan dari penelitian ini adalah untuk mengetahui perbedaan kemampuan pemecahan masalah siswa yang diberi pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web dengan siswa yang diberi pembelajaran konvensional. Penelitian ini menggunakan rancangan quasi exsperiment pretest-posttest control group design. Hasil rata-rata gain score tes kemampuan pemecahan masalah menunjukkan siswa yang dibelajarkan dengan pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web lebih tinggi daripada siswa yang dibelajarkan dengan pembelajaran konvensional. Hasil uji hipotesis menunjukkan bahwa siswa yang dibelajarakan dengan pembelajaran inquiry-discovery melalui tinjuan empiris-teoritis berbantuan web memiliki peningkatan kemampuan pemecahan masalah lebih tinggi daripada siswa yang dibelajarakan dengan pembelajaran konvensional, hal ini juga berlaku pada siswa yang berkemampuan awal tinggi maupun rendah.
THE RELATIONSHIP BETWEEN SELF-CONFIDENCE AND STUDENTS PERFORMANCE ‎IN BIOLOGY LAB EXCERCISE
Authors: Fadlilah Dina Rahma , Miarsyah Mieke , Azrai Eka Putri
Published: March 2020

Biology lab exercise are an important aspect on learning process. However, the outcome of the lab activity might not come as the curriculum goals expected. It is due to several reasons. This paper try to measure the relationship between students’ character and students’ performance in Biology lab exercise. This study used self-confidence as a proxy of students’ character. A unique Indonesian high school datasets and simple regression analysis were used for this research. Evidence shows that pupils’ self-confidence 3% among other variables that determine students’ performance and it has positive but insignificant impacts on students performance. The evidence demonstrates there is a weak relationship between self-confidence and students performance in lab practice. Keyword: self confidence; performance of students; Biology practice
THE USE OF POGIL MODEL (PROCESS-ORIENTED GUIDED-INQUIRY LEARNING) TO ‎INCREASE THE CONCEPT UNDERSTANDING OF STUDENTS ON REACTION RATE ‎TOPIC
Authors: Aulia Hanna , Saridewi Nanda , Yunita Luki
Published: March 2020

This study aims to determine the effect of application of POGIL model in improving student` understanding of the material on reaction rate. The method used in this research is Quasi Experiment with Non Equivalent Control Design research descriptions and sampling with purposive sampling technique.The instrument used in this research are 12 essay test instrument with conceptual understanding indicator covering ability to comprehend, apply, and analyze. In this reseacrh, obtained pretest score of control class as much as 26,10 and experiment class 24,86. Next, the score of posttest of concrol class is 62,48 and experiment class is 76,48. Based on the hypothesis test with the level of trust α (0,05) obtained by t-test of posttest data obtained that the value of sig (2-tailed) 0,00 < 0,005 and tcount< ttabel (6,521<2,045) which mean H0 rejected and H1 accepted so that it can be concluded that there is a significant influence on the application of POGIL model to student understanding of the material on the rate of reaction. Keywords :Concept Understanding; POGIL; Reaction Rate
Healthcare Expenditure on Childbirth in India: Two Part Model Analysis
Authors:   Guru Gobind Singh College for Women, Chandigarh-160019, India, Kaur Mandeep , Kumar Sumit ,   Sri Guru Granth Sahib World University, Fatehgarh Sahib-140407, India
Published: March 2020

The aim of the study is to estimate the extent and determinants of healthcare expenditure of inpatients on childbirth in India. The study is based on sample of 14510 women who gave birth to a child (whether live or still-birth, vaginal or caesarean). To estimate the determinants two-part models has been utilised. The results indicate that women spent on average around INR 9103 per childbirth in hospitals. There are also wide variations in the spending pattern of women on childbirth. Household size, economic status, occupation, religion, and caste impact the expenditure on childbirth in hospitals. There are also wide-variations in the spending of women belonging to different geo-graphical locations of India. Surgeries/caesarean or utilisation of facilities like special room and diagnostic tests etc. also significantly increase the expenditure. Women opting for public health facilities or having insurance spend less as compared to others. Government of India should increase investment in health to strengthen its current infrastructure. There is dire need to improve the quality of public health facilities, to reduce the regional imbalances in health facilities, to improve the coverage of health insurance in India for equitable and pro-people health facilities.
ON THE REGULATION OF THE SPECIAL PERIOD AS THE FACTOR AFFECTING
THE CRIMES CLASSIFICATION
Authors: Nikolaienko T. B.
Published: March 2020

It has been determined in the article that taking into account the measures for preventing military crime, there are problems regarding the usage of a special period as a qualifying circumstance in investigative and judicial practice.
The author has proved that in the current conditions in the east of Ukraine, amid the war crime growth, any violation of the military discipline order is a negative manifestation of the weakening of the military formations ability to reliably counteract the enemy, but also a direct threat to the national security of Ukraine. Hence, the issue of the special period unification has become problematic amid the increased criminal responsibility for committing crimes under the conditions of special period. They relate, in particular, to the time limits of the special period affecting the origin and termination of criminal legal relations, the qualification of crimes committed under the special period, and the possibility of applying the retroactive effect of the law in case of a change of legal regime in the state.
Investigating these issues, taking into account the acts of the current legislation, governing the categorical apparatus of the special period, the general rules for the legal norms interpretation and practice of the special period applying, the author has proved that the special period does not contain defining features in terms of its time limits unification, which affects the accuracy in norms’ content understanding, and accordingly its correct application.
In that context, the author has suggested the notion of “special period” where, from the point of view of its time limits, it is determined that the moment of its termination (in case of partial mobilization) is exclusively the promulgation of the President’s of Ukraine decision on demobilization. The content of “mobilization time” is the period from the beginning of mobilization (announcement of mobilization) to its termination (announcement of demobilization).
By analyzing the probability of the retroactive effect of the law in case of the special period ending, it has been proved that persons convicted for committing crimes in the conditions of the special period upon its completion are not subjected to the retroactive effect of the law as mitigating or abolishing liability, since the change of regime affects only the application of the law in terms of punishment imposition as having committed the crime of qualified composition.
PECULIARITIES OF RESPONSIBILITY OF A LAW ENFORCEMENT OFFICER
FOR COMMITTING AN INTENTIONAL MURDER IN REQUIRED DEFENSE
AND DETENTION OF A OFFENDER
Authors: Plysiuk N. M.
Published: March 2020

Questions about the peculiarities of the responsibility of a law enforcement officer for committing a premeditated murder in the performance of their duties in the context of necessary defense and detention of a criminal are explored. In the science of criminal law, one of the debates is the question of recognizing the subjects of premeditated killings when exceeding the limits of the necessary defense and when exceeding the measures necessary to detain the offender of law enforcement officers. In criminal law, there are several points of view regarding the qualification of actions of a police officer in causing them harm to the detained person and in the necessary defense. What are the causes of death in case of exceeding the limits of necessary defense or in case of exceeding the measures necessary for the detention of a person who committed a socially dangerous assault by a law enforcement officer – intentional murder if the limits of necessary defense are exceeded, or in case of exceeding the measures necessary for detention power or authority.
When deciding on the responsibility of a law enforcement officer in the conditions of necessary defense and detention of the perpetrator, it is necessary to establish: whether the requirements of the sectoral legislation regarding the grounds for the use of weapons, special means and physical influence measures have been met, and whether the requirement that “in case of impossibility to avoid the use of force, it shall not exceed the extent necessary to fulfill the duties assigned to the police and shall minimize the possibility of harming the offender's health to members of the public”. In compliance with both requirements, liability is excluded – such acts are not criminal. In case of non-compliance with such requirements, a law enforcement officer should be criminally responsible for a crime in the field of official activity. In addition, one should not forget that one of the conditions for the lawfulness of causing harm to a person in detention is the time of detention – immediately after the commission of the encroachment. With this in mind, in the deliberate killing of a detainee immediately after committing an encroachment on him, the actions of a law enforcement officer should be qualified under Art. 118 of the Criminal Code, and in the case of a similar act, if the detained person, for example, is wanted, for a similar crime – no. In such a case there will be, in the presence of signs, excess of power (Article 365 of the Criminal Code of Ukraine).
THE IDENTITY OF THE OFFENDER AS AN ELEMENT OF THE FORENSIC CHARACTERISTIC OF THE CRIME
Authors: Chaplynska Yu. A.
Published: March 2020

The scientific article deals with some aspects of crime investigation. The identity of the offender is considered as an element of forensic characteristics. Investigating the identity of the offender provides the investigation with a number of additional features. The identity of the offender as an element of forensic characteristics is a set of socially significant features and attitudes that characterize a person guilty of violating the criminal law, in combination with other conditions and circumstances affecting his criminal behavior. In particular, the information about it allows to distinguish the data necessary for the organization of the most effective search of the person who committed the crime, and subsequently – its exposition, provide elimination of the causes and conditions of committing criminal offenses and their recidivism. And during the conduct of investigative (search) actions – the possibility of effective establishment of psychological contact, the use of appropriate tactical techniques.
In order to construct an effective forensic characteristic, elements must be identified that have a clear investigative focus and can help determine further directions of the investigation. Therefore, it is indisputable to distinguish in the structure of forensic characteristics of crimes such component as the person of the offender. By identifying its characteristic features, it becomes possible to build versions at the initial stage of the investigation, to use certain tactical techniques in the course of procedural actions.
A forensic investigation of an individual consists of establishing forensically relevant information about the offender and other participants in the investigation process. Investigation of the identity of the offender as an element of forensic characteristics, allows to accumulate in the portrait of the likely offender his characteristic features. Creating a forensic portrait is important enough for the whole investigation process. In any case, it allows you to put forward certain versions and search for the person who disappeared from the scene, as well as the possibility of qualitative procedural actions.
HISTORY OF BECOMING LEGISLATION IN RELATION TO LEGAL STATUTE
A CHILDREN-INVALIDS ON WALKS IN THE LIFE OF UKRAINE
Authors: Butryn-Boka N. S.
Published: March 2020

This article is sanctified to research of question of history of becoming of legislation in relation to legal position of children-invalids. The row of documents, that assisted the bookmark of legislative foundation, that became the regulator of relations between the state, society and children-invalids, is outlined. The state is under an obligation not only at formal level to provide normal development of children-invalids but also incarnate in life necessary facilities for functioning. Social defence of invalids from the side of the state consists in the provision of benefit, motor, orientation and perception of information, adjusted accommodation vehicles, in establishment of guardianship or extraneous supervision, and also adaptation of building of settlements, public transport, facilities of communications and connection to the features of invalids. A manual is paid in accordance with a current legislation. In turn, local public authorities are under an obligation to provide to the invalids necessary terms for free access and using in a civilized manner-spectacle establishments and sport building, for engaging in physical education and sport, and also to provide grant the special sport to the inventory. Taking into account the necessity of approaching of national legislation to international to the state it is yet needed to pay attention to problems that arise up for people with disability : they are often confined and possibilities to participate in economic life. And it is a greater question of domestic barriers, but not possibilities of people with disability to work. From it, the large percent of people with disability appears on verge of poverty. Therefore, normative acts must be the instrument of realization of rights for children-invalids exactly now. It is well-proven that construction of the legal framework is based on the fact that not only is declared a particular set of guarantees for persons with disabilities, and the law establishes a procedure for their implementation and control over the implementation, which is able to ensure the implementation of the totality of social rights of persons.
LEGAL WAYS TO COMBAT INFORMATION RARE IN UKRAINE
Authors: Shcherbyna Ye. M.
Published: March 2020

In the article the problem of existence of informative corporate raid is investigated in Ukraine, legal ways of overcoming (minimizations of harm) of informative corporate raid in modern realities. In the epoch of information technologies the question of defence of the information and information becomes all more actual about itself in her primitive kind. And it touches not only the certain personal data but also information of пр business reputation of legal entity. Now the question of defence of business reputation of legal entities becomes urgent, through abuse of the certain interested citizens by the rights on offering a “own opinion”. By a basic problem, that will be considered in the real article there is an invention of ways of legal counteraction to the socalled “informative corporate raid”, consideration of variants of judicial and extrajudicial defence of the broken right.
Actuality of this theme consists in that an informative corporate raid does obstacle to normal economic activity of plenty of enterprises real to the sector of economy and ways of his overcoming or even.
An informative corporate raid deeply got to modern realities of Ukrainian societ. Corrupted of power, to accomplish imperfection of home legislation and not desire of organs of local selfgovernment active operating under defence it basic taxpayers legal entities is a favourable environment for distribution and greater taking root of such aggressive verbal attacks Ukrainian business. Only clear legislative settlement, and the debugged work of representatives of legal entities, executive, local selfovernmentand unindifferentcitizens bodies can overcome such negative phenomenon. Eradication of informative corporate raid will assist the improvement of economic and investment climate in a country that will result in the inevitable improvement of standard of livingorate raid will assist the improvement of economic and investment climate in a country that will result in the inevitable improvement of standard of living.
THE MODERN STATE OF SCIENTIFIC THOUGHT ISIN RELATION TO SUBJECTS OF CORPORATIVE LAW
Authors: Shcherbakova N. V.
Published: March 2020

The article is devoted research of question of the modern state of scientific thought in relation to studies about subjects of corporative law. There is actuality of theoretical and practical value of select problems, taking into account prevalence of different legal forms of legal entities in an economic turn.
The analysis of becoming and development of studies is conducted about subjects of corporative law. Specified, that transition of Ukraine from administratively command system to the market relations caused the appearance of new legal forms conducts of economic activity, which got partial embodiment in a national legislation which must was have time after stormy development of economic relations and design the most adequate forms of realization of business. It is rotined that the multidimensionalness of legal description of subjects of corporative law predetermines appearance of different scientific looks and approaches.
It is set that the modern state of studies about subjects of corporative law is characterized the presence of civil legal and economic legal approaches among which an author is select narrow and wide interpretation of circle of subjects of corporative law. It is found out, that such selection predefined by certain factors, in particular, by establishment of a particular branch belonging of corporative legal relationships, its’ legal nature and content, and also it is well-proven that list of participants, subjects of corporative legal relationships related to the selection of interests of the proper circle of persons, their defence.
Generalization is done, that the perspective is see subsequent research of problems of subjects of corporative legal relationships both in part of decision of general circle of these subjects and features of legal status of commercial companies, legal entities of corporative type created in different legal forms, taking into account importance of such developments, by conditioned euro-integration steps between Ukraine and EU in the sphere of legislation about companies and corporative management, and by adduction the legal adjusting over of activity of corporations to the requirements of international standards and gradual rapprochement with the rules of EU.
Handbook of Research on Digital Content, Mobile Learning, and Technology Integration Models in Teacher Education, edited by Jared Keengwe
Authors: Visedo Elizabeth
Published: March 2020

Handbook of Research on Digital Content, Mobile Learning, and Technology Integration Models in Teacher Education

Edited by Jared Keengwe

Hershey, PA: IGI Global

US $225

ISBN 9781522529538 (Hardback)

498 pages

2018
La dualización productiva normal: precisiones y ampliación. Bases antropológicas próximas de la actividad económica (I)
Authors: Falgueras-Salinas Ignacio , Falgueras-Sorauren Ignacio
Published: March 2020

Continuando una línea de investigación ya abierta, empezamos un segundo tramo de la misma con este trabajo, el cual se ocupa de: (i) precisar ideas ya esbozadas anteriormente, y (ii) ampliar en detalle el desarrollo de la dualización productiva normal, comenzando por su polo inferior. Con esto se introducen temas nuevos en los que ya se adelantan algunos rasgos que, aunque han sido considerados típicos de la actividad económica, aquí se muestra que no le pertenecen todavía, pero sí que, en cierto sentido, la preludian, razón por la cual los estimamos como primeras bases próximas de la misma.