bluuebunny/crossref_metadata_2025 huggingface dataset:
Body positive social media posts: who likes them anyway? The role of internalization and body dissatisfaction in the implicit and explicit bias towards thin-ideal social media posts
Authors: Schein Adél , Tódor Imre , Varga Attila , Koronczai Beatrix , Szőcs Levente Álmos , Nagy Bence , Stankovics Adél , Ágoston Csilla , Buvár Ágnes
Published: January 2025

Previous research demonstrated that body positive social media posts can foster body acceptance. However, the question arises about the susceptibility to body positive images and whether body positive social media posts can compensate for the harmful effects of unattainable beauty ideal internalization. This paper explored the role of internalization and trait body dissatisfaction in the implicit and explicit biases towards thin-ideal social media posts. We conducted two online studies (N = 673) with female participants of different age groups (adults, young adults, adolescents). Data was analyzed with path models. Results showed that in the adult and young adult samples, stronger internalization led to a more negative appreciation of body size, which was associated with a stronger implicit and explicit bias towards body-positive social media posts. However, in the adolescent sample, while internalization was directly positively related to the explicit bias towards thin-ideal posts, it was also positively associated with general body dissatisfaction that, in turn, was negatively related to the explicit bias towards thin-ideal posts. Our findings confirm that females with body image concerns are more susceptible to body positive posts that might compensate for the possible negative effects of internalization among (young) adults but not necessarily among adolescents.
Polyphenols and antioxidant activity of Sulla pallida from mining sites of Morocco: Implication for phytoremediation of heavy metal-contaminated pastures
Authors: YEMLAHI Anass EL , ZERRAD Hamass , Caprioli Giovanni , Acquaticci Laura , Annaz Houssam , ZERROUK Mounir HASSANI , LAGLAOUI Amin , ARAKRAK Abdelhay , BAKKALI Mohammed
Published: January 2025

An on-field survey was conducted to assess the physiological and symbiotic response of Sulla pallida in an abandoned mining site in Northeast Morocco. Results indicated that S. pallida maintained high nodulation and nitrogen efficiency even at late growth stages while accumulating significant levels of Fe, Pb, Zn, and Cu in its aerial parts. Phenol content varied significantly (p<0.05) by phenological stage and plant part, with a high concentration of total extractable polyphenols (7.73 %DM) and tannins (6.97 %DM) recorded during the vegetative stage. Antioxidant activity, as shown by DPPH radical scavenging (IC50 of 0.126 mg/mL), was comparable to the control (BHT, IC50 of 0.110 mg/mL). Anti-lipid peroxidation and ferric reduction potential were highest during flowering, with values outperforming controls in some assays. HPLC-ESI-MS/MS analysis identified 38 compounds, with high levels of 4-Hydroxy benzoic acid, rutin, vanillic, gallic, and p-coumaric acids. These findings highlighted S. pallid as a promising forage species for remediating heavy metal-contaminated pastures and promoting sustainable land use.
Early Evolution of BA.2.86 Sheds Light on the Origins of Highly Divergent SARS-CoV-2 Lineages
Authors: Escalera-Zamudio Marina , Tan Cedric , Dorp Lucy van , Balloux Francois
Published: January 2025

Since the emergence of SARS-CoV-2 in late 2019, highly divergent variants with novel constellations of mutations have periodically emerged to displace previously co-circulating virus lineages. The evolutionary mechanisms behind this process remain unclear, but the prevailing hypothesis supports emergence through single events followed by a rapid accumulation of mutations in individual long-term infections. In July 2023, the Omicron-descending BA.2.86 Variant of Interest (VOI) emerged to outcompete other virus lineages, with descending sublineages still dominating as of December 2024. We use BA.2.86 as a case study to test the hypothesis that highly divergent variants emerge during a single chronic infection. By applying a comprehensive suite of evolutionary analyses to independent high-resolution datasets, we identify a cluster of approximately 100 BA.2 genomes that fall directly ancestral and shorten the branch leading to BA.2.86, carrying some BA.2.86-specific lineage defining mutations. These genomes, sampled from multiple countries and at different timepoints, share a single ancestor dating back to December 2021. Additionally, we detect over 2600 earlier BA.2, BA.2.75, and XBB.1.5 genomes with multiple mutations later associated with BA.2.86. These genomes represent a standing genetic variation that likely facilitated a gradual evolution in the direct ancestry of this variant. We further uncover a complex evolutionary process involving recombination between the BA.2.75 and XBB.1.5 parental lineages. Together, our results challenge the notion of a single emergence event, and instead support a more complex scenario, with BA.2.86 likely having evolved over multiple transmission chains.
Intron retention, a novel method for evaluating the response to ketamine in patients with treatment-resistant depression
Authors: okada norihiro , Oshima Kenshiro , Maruko Akiko , Kobayashi Yoshinori
Published: January 2025

In response to a state of stress, the body attempts to maintain protein homeostasis through intron retention (IR). In other words, by examining which genes undergo IR under stress (i.e., IR genes), it is possible to analyze what type of stress the body is experiencing (Okada et al. 2024 Front.Psychiatry). Using this principle, we re-analyzed the RNA-seq data of non-responders and responders to ketamine, a drug with specific efficacy for depression, published by Cathomas et al. (2022), and examined IR genes to investigate what the substance of non-responders is. It was found that non-responders were individuals in a state of elevated viral infection. Several IR genes associated with viral infection were restored to a healthy state by ketamine regardless of whether an individual was a non-responder or a responder, so it is more reasonable to interpret that the non-responders are not individuals for whom ketamine does not work, but rather that the effects of ketamine do not catch up due to the extremely elevated inflammatory state of the non-responders. Furthermore, there is one transcriptomic outlier in the non-responders who shows an extreme increase in viral infection, but even if such an individual is excluded from the analysis, the above conclusions from the IR gene analysis remain essentially unchanged, whereas the DEG data were largely changed after this treatment. This further supports our previous claim that IR genes, but not DEGs, may be useful as markers of depression. This study is the first to describe the molecular basis of the difference between non-responders and responders.
WITHDRAWN: Zinc deficiency triggers ribosome remodeling to reverse biofilm azole resistance in Candida albicans
Authors: Wang Yingzhe , Ye Shigan , Deng Yuan , Huang Yingting , Zhu Xiaoliang
Published: January 2025

Biofilm formation is a key cause of high azole resistance and prolonged infection in Candida albicans. Zinc ion is involved in the regulation of biofilm formation and azole resistance in C. albicans, but its specific role remains unknown. We assessed the alteration of azole resistance in C. albicans biofilm in vivo and in vitro by inducing zinc deficiency, and found that zinc deficiency inhibits biofilm formation, reduces the activity of efflux pumps, enhances cellular metabolism levels, reduces in vivo pathogenicity, and ultimately reverses azole resistance. RNA-seq showed that zinc deficiency promotes cell survival under zinc deficiency by triggering intracellular ribosome remodeling, and downregulates the expression of genes related to biofilm core transcription factors and efflux pumps and upregulates the expression of genes related to glucose metabolism. This study provides new insights into the treatment of clinical C. albicans infections, particularly biofilm-associated highly resistant and persistent infections, by targeting zinc.
Study on the mechanism of action of Jingfang mixture against carrageenan-induced thrombosis in rats based on the gut-liver axis
Authors: Ni Wenting , Wang Yunyu , Li Shirong , Cao Qingyu , Sun Chenghong , Yao Jingchun , Zhang Guimin
Published: January 2025

The incidence of thrombosis-related diseases is increasing globally, and it is often treated by mechanical thrombectomy, intravenous thrombolysis and antiplatelet, but it is easy to lead to drug resistance and bleeding complications, which limits the development of its treatment. The gut-liver axis represents a complex two-way communication system, in which intestinal microorganisms not only affect intestinal immunity and intestinal function, but also regulate the coagulation function of the liver. Jingfang Mixture (JF) is a Traditional Chinese Medicine (TCM) that have the function of antithrombotic, but the mechanism is still unclear. This study is aimed to explore the regulatory effect and mechanism of JF on thrombosis rats through the gut-liver axis through a carrageenan-induced rat model. The results showed that after JF treatment, the degree of black tail in rats with thrombosis was significantly reduced, the pathological condition of the tail was improved, the four coagulation parameters and the levels of coagulation factors were adjusted closely to the normal levels, and the levels of liver and intestinal inflammatory factors were significantly reduced. In vitro experiments proved JF had little effect on platelet aggregation, release, and coagulation. In our study, JF can significantly elevate the levels of intestinal tight junction proteins and improve intestinal flora disorders, alleviate the oxidative stress level in the liver, and improve the short-chain fatty acid levels in the feces of rats with thrombosis. Of note, the relative abundances of Clostridia_UCG-014, Ruminococcaceae, Eggerthellaceae, Monoglobaceae and Rikenellaceae were significantly were decreased after JFM intervention. Proteomic results showed that the antithrombotic effect of JF may be related to the coagulation and complement cascade signaling pathway. The gene and protein expression of FGA, FGB, FGG and C3 were elevated after JF treatment, respectively. Finally, we further confirmed the therapeutic effect through fecal microbiota transplantation (FMT) experiments, that the crosstalk of the gut-liver axis contributed to the improvement of thrombosis after JF treatment. In summary, this study took the gut-liver axis as the breakthrough point and coupled with 16S rDNA sequencing, non-targeted metabolomics, TMT-based quantitative proteomics and related comprehensive analysis methods, showing that JF can improve the intestinal flora and immune system disorder, as well as reduce the inflammatory damage of intestinal and liver in carrageenan-induced thrombosis rats, and its protective effect may be related to the complement and coagulation cascade signaling pathway. This study accurately explains the multi-target and multi-pathway mechanism of JF in treating thrombosis-related diseases, which can provide reference for further clinical application.
Bridging the Medication Adherence Gap from Therapeutic Drug Monitoring: A Bayesian approach for Anti-Seizure Medications
Authors: Jiao Zheng , Liu Xiao-Qin , Li Zi-Ran , Lin Wei-Wei , Wang Juan , Gu Fu-Qing , Ding Junjie
Published: January 2025

Background: Adherence to antiseizure medications (ASMs) is crucial for the success of treatment. However, current recommendations for assessing medication adherence through therapeutic drug monitoring (TDM) may overlook individual patient characteristics, potentially leading to misjudgments. This study aims to evaluate the capability of a Bayesian approach in assessing adherence for 14 ASMs using TDM.
Method: A Bayesian framework incorporating population pharmacokinetics was used to assess adherence using TDM data. Additionally, the impact of patient characteristics, concomitant medications, sampling times, and prior adherence probability was examined.
Results: With essential patient information, such as age, weight, and scheduled dosing regimen, the Bayesian approach effectively assessed recent adherence for all investigated ASMs. The concentration thresholds varied by ASM and were influenced by patients' characteristics. To facilitate individual adherence evaluations, a web-based dashboard was developed.
Conclusion: The integration of Bayesian methods with pharmacokinetics significantly enhances the reliability of TDM in assessing adherence to ASMs.
IMRC-Exo Alleviates Limb Injury Induced by Deinagkistrodon acutus Snakebite in Rabbits Through GSDME-Dependent Pyroptosis Inhibition
Authors: Wu Haohao , Xie Lutao , Du Wang , Lai Linjie , Shangguan Peixin , Wu Xingzhen , Xu Jiefeng , Lan Pin
Published: January 2025

Background
Inflammation plays a critical role in the pathogenesis of limb injury caused by Deinagkistrodon acutus snakebite. Investigating its regulatory mechanisms and intervention strategies may uncover effective therapeutic approaches for this condition. Recent studies have identified pyroptosis as a key pathway exacerbating target organ damage by amplifying inflammatory responses. Immune and Matrix-Regulatory Cells (IMRC), a novel type of mesenchymal stem cell, and their derived exosomes (Exo) that have shown potential in mitigating inflammation-mediated tissue damage by suppressing pyroptosis. This study aimed to evaluate whether IMRC-Exo could alleviate Deinagkistrodon acutus venom-induced limb injury by inhibiting pyroptosis-mediated inflammation in rabbits.
Methods
Eighteen healthy male New Zealand white rabbits were randomly assigned to the Sham, Model, and IMRC-Exo groups. The Model group was established by intramuscular injection of Deinagkistrodon acutus venom (1.5 mg/kg), followed by intravenous infusion of anti-D. acutus venom serum (80 U/kg) after 2 hours. The IMRC-Exo group received IMRC-Exo treatment (7.5 × 10^10 particles) after model establishment. Within 24 hours post-modeling, the left thigh circumference, serum creatine kinase (CK), and myoglobin (Mb) levels were dynamically assessed. Animals were euthanized to collect muscle tissues for histopathological examination, apoptosis analysis, inflammatory cytokine quantification (HMGB1, IL-1β, IL-18), and pyroptosis-related protein detection, including caspase-3, cleaved caspase-3, gasdermin E (GSDME), and N-terminal GSDME (N-GSDME).
Results
Compared with the Sham group, both venom-injected groups exhibited a significant increase in left thigh circumference, elevated serum CK and Mb levels, and aggravated histopathological damage and apoptosis in muscle tissues. However, the IMRC-Exo group showed significantly reduced limb circumference, decreased muscle injury markers, and attenuated tissue damage compared with the Model group. Additionally, venom injection significantly increased HMGB1, IL-1β, IL-18 levels, and the expression of caspase-3, cleaved caspase-3, GSDME, and N-GSDME in muscle tissues of the Model and IMRC-Exo groups compared to the Sham group. Notably, these inflammatory cytokine levels and pyroptosis-related protein expressions were significantly lower in the IMRC-Exo group than in the Model group.
Conclusion
IMRC-Exo effectively alleviates limb wound damage induced by Deinagkistrodon acutus snakebite in rabbits. Its protective mechanism may involve the inhibition of GSDME-dependent pyroptosis-mediated inflammatory injury.
The Omics Molecule Extractor: A web application for the selection of potential biomarker panels
Authors: Lange Emanuel , Schallert Kay , Schwerdt Johannes , Ghosh Susmita , Hentschel Andreas , Reinders Yvonne , Heyer Robert
Published: January 2025

Selecting molecule panels that are applicable to classify the health state of patients is a common task in omics data analysis. Existing software for molecule selection lacks features to select molecule panels from large datasets, requires programming experience, or lacks user-friendly interfaces. We present the Omics Molecule Extractor (OMEx) an open-source web application providing a user-friendly workflow for selecting molecules and molecule panels for sample classification from large datasets. OMEx’s user interface provides interactive visualization for exploring input data and analysis results. The feature selection strategy underlying the algorithm is based on machine learning and has not been available in any software with user interface. Extensive testing using synthetic datasets with known ground truth showed that the algorithm discovers group-separating molecules with high precision. Additionally, OMEx was tested on five real-world omics datasets demonstrating high reproducibility and overlap with reported molecules from other feature selection methods, while also reporting alternative molecules of interest. OMEx is freely available at https://mdoa-tools.bi.denbi.de/omex/home.
A Study of Gender-Specific Learning Patterns in Online Medical Education
Authors: Moranges Maëlle , Ibrahim Noha , Amer-Yahia Sihem , Palombi Olivier
Published: January 2025

This study explores gender-specific learning patterns among medical students using an online educational tool utilized at the national level in France. Despite increasing numbers of women in medical school admissions, persistent disparities in professional medical careers raise concerns that such inequalities may already be present during university training. In this study, we analyze data from all fourth-year medical students in France for the academic years 2022-2023 and 2023-2024. We employ a Subgroup Discovery algorithm to identify patterns in online engagement and performance within these two national cohorts, focusing on gender as the key demographic variable. Our analysis revealed significant gender differences, with a proportion of male students displaying higher levels of engagement and academic performance. In contrast, female students were more likely to disengage from interactive components of the platform or to perform poorly or averagely in some medical specialties. We hypothesize that these differences may be attributed to the nature of the evaluations, which are predominantly in multiple-choice question format, potentially favoring male students. Additionally, stress and psychological distress, which are known to affect female students, may further exacerbate these performance disparities. These findings underscore the need for targeted interventions in medical education to address early gender disparities, promoting a more equitable learning environment for all students.
Rainfall patterns and their association with flood fatalities across diverse Euro-Mediterranean regions over 41 years
Authors: Papagiannaki Katerina , Lagouvardos Konstantinos , Kotroni Vassiliki , Diakakis Michalis , Kyriakou Petros
Published: January 2025

Flood fatalities remain a critical challenge in the Euro-Mediterranean region. This study analyses 2,245 fatalities from 11 territories (1980–2020) using the FFEM-DB and the global MSWEP rainfall dataset. Extreme rainfall is shown to be a significant risk factor, with fatal floods in many regions associated with rainfall exceeding the 99th percentile of daily values over 41 years. However, in some territories, fatalities also occurred under less severe rainfall, reflecting regional differences in exposure and vulnerability. In the South EU-Mediterranean, deadly floods are triggered mainly by higher rainfall than in the Central EU. Autumn is the most hazardous season, though summer floods in the South EU-Mediterranean demonstrate heightened exposure and impact severity. The findings are discussed in light of the climatology, geomorphology, and societal vulnerabilities, highlighting the importance of tailored management strategies to address regional disparities, particularly as climate change intensifies rainfall patterns across the Euro-Mediterranean region.
Neoadjuvant Immunotherapy as a risk factor for Hashimoto's Disease
Authors: Araujo-Filho Irami , Meneses do Rêgo Amália Cinthia
Published: January 2025

This review investigates the association between neoadjuvant immunotherapy and the onset of Hashimoto's disease in patients with neoplastic conditions. With the increasing use of immunotherapy in oncology, understanding potential immune-related adverse events, particularly autoimmune thyroiditis, is crucial for optimizing patient outcomes and managing therapy-related risks. Our findings suggest a notable incidence of Hashimoto's disease among cancer patients receiving neoadjuvant immunotherapy. The underlying mechanisms may involve immune checkpoint inhibitors disrupting immune tolerance, leading to autoimmune thyroiditis. This review highlights the need for vigilant monitoring of thyroid function in patients undergoing immunotherapy and suggests potential strategies for early detection and management of Hashimoto's disease in this population. Further research is required to elucidate the precise mechanisms and risk factors involved, which could inform clinical guidelines and improve patient care.
Instrumentação e montagem da mesa cirúrgica para sinusectomia via endoscópica
Authors: Queiroz de Aguiar Lucas , Bezerra Freitas Rayane , Maciel Ana Luisa Silva , De Azevedo Queiroz Raissa , Dantas Palmeira Wendell
Published: January 2025

Introdução: A sinusectomia objetiva o retorno da funcionalidade adequada dos seios paranasais, com recuperação e restauração da mucosa sinusal, em que a utilização do endoscópio torna a cirurgia menos invasiva e mais efetiva. Objetivos: Este artigo de revisão propõe listar os instrumentos cirúrgicos utilizados na sinusectomia por via endoscópica, assim como é realizada a preparação da mesa cirúrgica. Métodos: Didaticamente, imagens reais dos instrumentos cirúrgicos e da mesa cirúrgica dispostos adequadamente para a instrumentação. Conclusão: A utilização de instrumentos cirúrgicos corretamente permite que o procedimento cirúrgico seja mais efetivo e alcance seu objetivo.
Identificação e genotipagem do vírus da síndrome da mancha branca (WSSV) isolado de Litopenaeus vannamei no estado do Rio Grande do Norte
Authors:   , Peixoto Emanuelly Cristina Rodrigues
Published: January 2025

A síndrome da mancha branca é uma doença notificável cujo agente etiológico é o Vírus da Síndrome da Mancha Branca (White Spot Syndrome Virus - WSSV) responsável por graves perdas econômicas na carcinicultura mundial. Desde 2012, têm sido verificados registros oficiais da presença do vírus no estado do Rio Grande do Norte - RN , região de extensa produção camaroneira. Apesar da importância, pouca informação tem sido produzida quanto às origens e biodiversidade dos virus circulantes. Diante disso, objetivou-se investigar a presença do vírus em criações de Litopenaues vannamei oriundos de fazendas do RN, bem como realizar a genotipagem dos isolados. Um total de cinco fazendas foram submetidas ao estudo, das quais foram coletadas 10 amostras de cada. Foram selecionados dois viveiros de cada uma das fazendas, escolhidos mediante suspeita clínica de WSSV. O DNA genômico foi extraído para investigação da presença ou ausência do vírus através da reação em cadeia da polimerase (PCR). Posteriormente, foi realizada por PCR a genotipagem dos isolados utilizando as repetições em tandem de número variável – VNTR (ORFs 75, 94 e 125). Os resultados revelaram a presença do vírus em apenas uma das 5 fazendas analisadas. As regiões (ORF 75 e ORF 94) foram identificadas nos isolados da fazenda positiva e não houve amplificação para o ORF 125. O número de unidades repetidas (RUs) foi calculado, sendo verificado 9 repetições para o ORF 75 e 10 para o ORF 94, um padrão que ainda não havia sido descrito, alertando para a necessidade de mais isolados caracterizados geneticamente para o rastreamento e vigilância epidemiológica da doença.
To Punish or Reintegrate? Balancing Legal Protection and the Future of the Child Terrorist
Authors: Khalid Ihab Natiq , Hassan Muhamad Sayuti , Said Muhammad Helmi Md
Published: January 2025

In West Asia regions such as Iraq and Syria, children are vulnerable to terrorists, especially the Islamic State of Iraq and Syria (ISIS). Iraq has suffered years of massacre by ISIS using children recruited and transformed into “lions”. This resulted in the enactment of the Iraqi Anti-Terrorism Law in 2005 to address the menace. However, this law did not distinguish between adult offenders and child offenders; rather, it issued general punishment for the crime of terrorism. The study aims to determine the justification for punishment for child terrorists in light of the surrounding circumstances of indoctrination and transformation into dehumanized humans. Studies on child recruitment by ISIS, child soldiers, and ISIS and children were collected and analyzed using doctrinal legal analysis. The findings were thematically analyzed and discussed accordingly. It was discovered that justification for the punishment of children recruited by ISIS would be more effective when certain factors like the method of child recruitment are examined, the experiences of the children, and the impact the recruitment has had on the recruited children to avoid recidivism. That has turned them into terrorists and lacking human sympathy. This study suggests the need to punish these children under the provision of Juvenile Welfare Care with the purpose of de-radicalizing, rehabilitating, and reintegrating them into society while considering the safety of the community. Relevant strategies are essential for safeguarding the future of children and protecting their human rights.
O Brasil na TAP. Representações Luso-Brasileiras na Produção Cultural da Companhia Aérea de Bandeira Portuguesa
Authors: Vanspauwen Bart Paul
Published: January 2025

A combinação de contributos dos estudos pós-coloniais, de património e de mobilidade constitui um prisma privilegiado para análise das metáforas de viagem e encontro. Tal como Paul Gilroy (1993) considerou os navios coloniais unidades culturais e políticas que navegavam nas várias partes do mundo atlântico, também é possível considerar, no presente pós-colonial, que os aviões transatlânticos servem de mediadores nas dimensões culturais e políticas das viagens. Sem dúvida, e durante os seus quase 80 anos de existência, a companhia aérea de bandeira TAP Air Portugal tem vindo a desempenhar um papel fundamental na conexão das comunidades de língua portuguesa dispersas geograficamente, mas ligadas política, económica, cultural e afetivamente. Após os importantes eventos institucionais, e relativamente recentes, como a fundação da Comunidade de Países de Língua Oficial Portuguesa, em 1996, e a Exposição Mundial de Lisboa de 1998, as relações pós-coloniais lusófonas ficaram mais visíveis, tanto internacionalmente quanto internamente. E nas representações de elementos da cultura expressos pela TAP, o Brasil tem tido um papel dominante. Enquadrando o meu trabalho em debates sobre a promoção de memórias sociais e patrimónios culturais, pretendo compreender a maneira como as relações luso-brasileiras têm vindo a ser representadas pela TAP. A nível metodológico, realizo uma análise do discurso, que incide sobre as noções usadas pela TAP (tais como “abraço”, “amizade” e “hospitalidade”); teoricamente, problematizo entendimentos sobre os conceitos de “portugalidade” e “brasilidade” como elementos-chave da ideia de “lusofonia”.
Collaborative Development of Feedback Concept Maps for Virtual Patient–Based Clinical Reasoning Education: Mixed Methods Study
Authors: Mayer Anja , Hege Inga , Kononowicz Andrzej A , Müller Anja , Sudacka Małgorzata
Published: January 2025

Background

Concept maps are a suitable method for teaching clinical reasoning (CR). For example, in a concept map, findings, tests, differential diagnoses, and treatment options can be documented and connected to each other. When combined with virtual patients, automated feedback can be provided to the students’ concept maps. However, as CR is a nonlinear process, feedback concept maps that are created together by several individuals might address this issue and cover perspectives from different health professionals.

Objective

In this study, we aimed to develop a collaborative process for creating feedback concept maps in virtual patient–based CR education.

Methods

Health professionals of different specialties, nationalities, and levels of experience in education individually created concept maps and afterward reached a consensus on them in structured workshops. Then, medical students discussed the health professionals’ concept maps in focus groups. We performed a qualitative content analysis of the transcribed audio records and field notes and a descriptive comparison of the produced concept maps.

Results

A total of 14 health professionals participated in 4 workshops, each with 3‐4 participants. In each workshop, they reached a consensus on 1 concept map, after discussing content and presentation, as well as rationales, and next steps. Overall, the structure of the workshops was well-received. The comparison of the produced concept maps showed that they varied widely in their scope and content. Consensus concept maps tended to contain more nodes and connections than individual ones. A total of 9 medical students participated in 2 focus groups of 4 and 5 participants. Their opinions on the concept maps’ features varied widely, balancing between the wish for an in-depth explanation and the flexibility of CR.

Conclusions

Although the number of participating health professionals and students was relatively low, we were able to show that consensus workshops are a constructive method to create feedback concept maps that include different perspectives of health professionals with content that is useful to and accepted by students. Further research is needed to determine which features of feedback concept maps are most likely to improve learner outcomes and how to facilitate their construction in collaborative consensus workshops.
Evolution of Artificial Intelligence in Medical Education From 2000 to 2024: Bibliometric Analysis
Authors: Li Rui , Wu Tong
Published: January 2025

Background

Incorporating artificial intelligence (AI) into medical education has gained significant attention for its potential to enhance teaching and learning outcomes. However, it lacks a comprehensive study depicting the academic performance and status of AI in the medical education domain.

Objective

This study aims to analyze the social patterns, productive contributors, knowledge structure, and clusters since the 21st century.

Methods

Documents were retrieved from the Web of Science Core Collection database from 2000 to 2024. VOSviewer, Incites, and Citespace were used to analyze the bibliometric metrics, which were categorized by country, institution, authors, journals, and keywords. The variables analyzed encompassed counts, citations, H-index, impact factor, and collaboration metrics.

Results

Altogether, 7534 publications were initially retrieved and 2775 were included for analysis. The annual count and citation of papers exhibited exponential trends since 2018. The United States emerged as the lead contributor due to its high productivity and recognition levels. Stanford University, Johns Hopkins University, National University of Singapore, Mayo Clinic, University of Arizona, and University of Toronto were representative institutions in their respective fields. Cureus, JMIR Medical Education, Medical Teacher, and BMC Medical Education ranked as the top four most productive journals. The resulting heat map highlighted several high-frequency keywords, including performance, education, AI, and model. The citation burst time of terms revealed that AI technologies shifted from imaging processing (2000), augmented reality (2013), and virtual reality (2016) to decision-making (2020) and model (2021). Keywords such as mortality and robotic surgery persisted into 2023, suggesting the ongoing recognition and interest in these areas.

Conclusions

This study provides valuable insights and guidance for researchers who are interested in educational technology, as well as recommendations for pioneering institutions and journal submissions. Along with the rapid growth of AI, medical education is expected to gain much more benefits.
The Relationships between ESG Responsibility, Earnings Management, and Tax Aggressiveness: Evidence of the Halo Effect from Indonesia
Authors: Ekawati Erni
Published: January 2025

Introduction/Main Objectives: Sustainable firms should develop competitiveness by seeking interconnections between financial and non-financial goals. This research investigates the halo effect to shed light on the motives behind environmental, social, and governance (ESG) responsibility and tax aggressiveness engaged in by the firms dealing with real earnings management (REM). Background Problems: Do higher ESG scores improve corporate value due to corporate credibility and ethical practices, or due to the motive of doing good to cover up irresponsible practices? Novelty: Only a few studies have investigated the motivation of Indonesian companies in carrying out ESG, associated with REM and tax aggressiveness to test for a halo effect. Research Methods: This study is based on a sample of manufacturing companies listed on the Indonesia Stock Exchange between 2015 and 2019. Panel data regression models are used in testing the hypotheses. Finding/ Results: ESG scores have a positive effect on market value. The halo effect is present in manufacturing firms practicing REM. Firms entering into REM have significantly higher ESG scores. REM has a negative effect while ESG scores have a positive effect on tax aggressiveness. Conclusion: ESG scores could increase firms’ value. However, the presence of the halo effect results in higher ESG scores for firms engaging in REM. The REM activity prevents firms from aggressive tax planning, while governance responsibility encourages them to do so. The halo effect opens up the opportunity to engage in REM and tax aggressiveness. Thus, the government requires scrutiny considerations in order to avoid the unfavorable side effects of ESG enforcement.
Does the Use of Solid Cooking Fuels Increase Household Out-Of-Pocket Medical Expenses? Evidence from Indonesia
Authors: Siagian Theo Ojahan Pardamean , Hartono Djoni
Published: January 2025

Introduction/Main Objectives: The objective of this study is to assess how the utilization of solid cooking fuels influences out-of-pocket medical expenses incurred by households in Indonesia. Background Problems: Solid cooking fuel use remains prevalent in Indonesia, negatively impacting the health of household members, and consequently affecting associated medical expenses as well. Novelty: To the best of the authors’ understanding, this study is the first to explore how the use of solid cooking fuels affects the out-of-pocket medical expenses of households in Indonesia. Research Methods: This study employs instrumental variables to address existing endogeneity issues. Finding/ Results: On average, households using solid cooking fuels show a 0.0041 increased proportion of out-of-pocket medical expenses to total household expenditure compared to households using non-solid cooking fuels. Conclusion: The Indonesian government can reduce household medical expenses by improving the use of cleaner cooking fuels. Implementable policies include providing assistance with clean energy cooking equipment and ensuring the availability of clean energy in areas in need.
Internal Whistleblowing and Perceptions of Organizational Politics, Pressure, and Professional Commitment
Authors: Risty Ilyona , Aprilia Beta Suandi  , Alif Muhammad Ikhsan
Published: January 2025

Introduction/Main Objectives: This study examines the influence of organizational political perceptions of internal whistleblowing intention, specifically investigating the role of professional commitment on the pressure felt by employees within the framework of the conservation of resources theory. Background Problems: Previous research has focused on what factors can increase internal whistleblowing intention, while there are contextual factors that cannot be ignored, specifically the state of the working environment that may hinder such intention. Novelty: This research investigates a different phenomenon from the point of view of an environment that creates a negative perception while also linking it to the professional commitment to the impact of internal whistleblowing intentions. Research Methods: This study employs a questionnaire-based survey method targeting employees of banks affiliated with the Association of Stated-Owned Banks in Indonesia. The sample consists of 115 participants and the data were analyzed using structural equation modeling (SEM). Findings/Results: The findings of this research suggest that employees' views on organizational politics and the corresponding pressure hinder their willingness to report violations. Nevertheless, a strong level of professional dedication does not lessen the impact of organizational politics on perceived pressure. This underscores the necessity for organizations to cultivate a cooperative atmosphere that can diminish the adverse perceptions of organizational politics. Conclusion: This research carries particular importance, notably within the financial industry, illustrating how the interactions among organizational politics, pressure, and professional commitment influence employees' tendency toward internal reporting of misconduct. Further, this research enriches the discourse on internal whistleblowing, providing a richer conceptualization of its determinants from both environmental and situational perspectives.
What Drives Youth to Shop for Local Fashion Online? Extending the Planned Behavior Theory and Ethnocentrism
Authors: Kartikasari Dwi , Zuliarni Sri , Hati Shinta Wahyu , Anggraini Ria , Sari Desi Ratna , Andayani Nur Rahmah
Published: January 2025

Introduction: Local businesses and lawmakers in emerging economies are under tremendous pressure to compete with foreign entities and comprehend consumer behavior in the setting of increasing interna­tionalization and the growing significance of e-commerce. Main Objectives: By adding to the theory of planned behavior and consumer ethnocentrism, this study aims to find the factors that affect people's intentions to buy local products in the context of e-commerce, fashion, youth, and Indonesia. Methods: Nonprobability snowball online sampling on social media was conducted to collect 651 valid responses. Findings/Results: We used a variance-based partial least squares structural equation model to show that attitudes, perceived behavioral control, subjective norms, and consumer ethnocentrism, directly and indirectly, affect people's intentions to buy local goods online. Conclusions: In our structural model, we stress how vital consumer ethnocentrism and subjective norms are as internal and external factors for consumers. Implications: We encourage managers of local businesses and future researchers to include these concepts in their marketing plans and research. Novelty: This research shows that consumers react differently to the opposite sign of consumer ethnocentrism when they deal with subjective norms as an outside factor because of competitive mediation. Limitations: The generalizability of our findings to different countries, situations, and product categories is limited, so we suggest future research expand beyond our scope.
Exploring the Dynamics of Work Satisfaction and Innovation Among Young Lecturers in Post-Pandemic Indonesia
Authors: Dara Despinur , Saparuddin Saparuddin
Published: January 2025

Introduction/Main Objectives: This study purposes to investigate the complex relationship among work autonomy, work crafting, work satisfaction, and innovative work behaviour. Background Problems: How autonomy, crafting, and work satisfaction relate and, more collectively, affect young lecturers' innovative work behaviours within the shifting educational circumstances in Indonesia is a major concern. Novelty: This research has groundbreaking importance because it applies the self-determination theory to this particular academic context of Indonesia. It emphasises the impact of cultural variations on the motivation and behaviour of young lecturers. It offers an innovative perspective on how young lecturers may be innovative and adaptable in the face of pedagogical and technical changes that are occurring at a fast rate. Research Methods: The study uses a mixed method approach in which 382 young lecturers from state universities in Indonesia participate in surveys, in-depth interviews, and participatory observations. By using structural equation modelling (SEM) by Lisrel and systematically coded by NVIVO, it becomes possible to analyse the complex interrela­tionships between the variables. Finding/Result: Work crafting on work satisfaction and work satisfaction on innovative behaviour has a significant positive impact. In contrast, work autonomy has no significant influence on lecturer work satisfaction. Excessive autonomy and interference without assistance will lower lecturer work satisfaction. In a dynamic educational environment, encouraging young lecturers to use creative teaching techniques and having institutional support can boost their creativity. Conclusion: What is brought into sharp focus through this study is the balance of autonomy with adequate support for young lecturers in a world that is rapidly developing in terms of digital education. Thus, pressure exists in universities to ensure young lecturers enjoy convenience in their work and support them to ensure they obtain the institutional support and work tools required in the digital era.
Efektivitas Komunikasi Perubahan Sosial dan Perilaku dalam Peningkatan Pengetahuan Gizi Remaja: Scoping Review
Authors: Maulidiyanti Mareta , Hawadi Lydia Freyani , Anshari Dien
Published: January 2025

Latar Belakang: Masa remaja perempuan merupakan masa krusial dalam mengembangkan pola makan bergizi yang berdampak pada kesejahteraan reproduksi di masa depan. Upaya preventif melalui edukasi gizi yang efektif khususnya pada remaja yang memiliki peran penting pada kualitas sumber daya manusia sangat krusial untuk dilakukan dalam jangka panjang. Namun, studi evaluasi berbagai pendekatan komunikasi perubahan sosial dan perilaku belum komprehensif sehingga menunjukkan pentingnya penelitian dibidang ini.Tujuan: Penelitian ini bertujuan untuk mengkaji bagaimana intervensi Komunikasi Perubahan Sosial dan Perilaku (KPSP)/Social Behavior Change Communication (SBCC) dengan berbagai platform dapat  meningkatkan pengetahuan dan kesadaran remaja perlunya gizi seimbang, serta mendorong penerapan kebiasaan makan sehat.Metode: Penelitian menggunakan metode scoping review yang dilakukan berdasarkan pedoman PRISMA. Terdapat 1142 artikel teridentifikasi diawal. Setelah ekstraksi dilakukan dengan melihat relevansi maka 13 artikel dipilih untuk dianalisis.Hasil: Hasil menunjukkan bahwa pendidikan gizi berbasis media sosial dan booklet menjadi platform yang paling efektif untuk menjangkau remaja, sementara pendekatan berbasis komunitas memberikan dampak yang lebih mendalam melalui dukungan personal.Kesimpulan: Penelitian ini menemukan bahwa penanganan  KPSP, yang diterapkan melalui berbagai platform secara efektif mendorong perubahan positif dalam perilaku melalui penggunaan pesan dan intervensi yang terfokus melalui berbagai media
Reclaiming Dignity: A Study on Transgender Experiences in Truth About Me: A Hijra Life Story
Authors: M S Anjana
Published: January 2025

Transgender people in India, often referred to as hijras, aravanis, or kothis, have a rich cultural history but face significant challenges in contemporary society. Despite their recognized presence in Indian culture and religion for centuries, they encounter widespread discrimination, marginalization, and violence. Most of the violences and prejudices transgender individuals are facing due to their gender identity and expression. These violations are compounded when intersecting with other social categories such as caste, class, ethnicity, and disability. They face substantial barriers in accessing education and employment. When it comes to educational settings, they experience bullying, harassment, and exclusion, leading to high dropout rates. The influences of these intersectional factors are evident in A. Revathi’s Truth About Me: A Hijra Life Story. Her autobiography depicts the life and struggles of the ‘Third Sex’ in Indian society. Revathi is an Indian transgender activist and a writer. She writes about the unspoken tales of the transgender lives and how they are socially stigmatized under the mainstream point of view. Truth About Me is one of the seminal works in literature which explores the complexities faced by transgender individuals in India. It discusses how the mainstream society mistreats and subjugates the transgender community within the constitution and law where all have the equal right to live regardless to sex, caste, gender, etc.
Unravelling the Invisible Spatial Logic: Spatial Production of the Clothing Wholesale Service Area in the Liuhua District in Guangzhou, China
Authors: Guo Fangjie
Published: January 2025

This article focuses on an unplanned clothing wholesale district in Guangzhou City, China. Dramatic Chinese Economic Transition and the district’s advantageous location next to the Guangzhou Railway Station have led to its commercial success. Smaller clusters of clothing wholesale buildings, clothes processing shops, shop design companies, tag shops, mannequin shops and logistics companies constitute this district. This research aims to understand how these smaller clusters choose their locations in the district without holistic urban planning in advance. By following the Actor-Network Theory, this research regards spaces as actors among other human and non-human actors and adopts a bottom-up perspective to investigate the spatial structures of the district. Qualitative methods including observation, semi-structured interviews and mapping are used. This research has found that invisible spatial logics behind the physical structures have induced the formation of the district, businesspeoples’ location choices and their spatial appropriations. This research goes beyond the visible forms and shapes to investigate the urban dynamics and complexities. It offers new perspectives to understand the spatial structures of urban spaces from the perspectives of space end-users.
Casos de enseñanza: Aprendizaje situado para solucionar problemas complejos y tomar decisiones
Authors: Díaz Barriga Frida , Heredia Sánchez Abraham
Published: January 2025

Aprendizaje situado para solucionar problemas complejos y tomar decisiones
Paulo Freire, uno de los grandes educadores latinoamericanos, dijo que la educación
tiene sentido porque los seres humanos somos proyectos y, a la vez, podemos tener
proyectos para el mundo. Estamos convencidos de que las y los docentes asumen el
compromiso de diseñar propuestas educativas que apoyan el aprendizaje de sus
estudiantes y que contribuyen a superar realidades complejas como la desigualdad social,
migración, violencia, exclusión y discriminación.
Mediante la propuesta del método de casos de enseñanza es posible transitar hacia una
mirada crítica y creativa que fortalezca la acción educativa ante escenarios complejos y que
requieren abordarse desde enfoques inclusivos y de justicia social. Esta publicación ofrece una
serie de principios y recursos educativos para diseñar e implementar el método de casos en la
formación y práctica docente con un enfoque centrado en el aprendizaje. El lector podrá
acceder a ejemplos modélicos de casos, sitios web con colecciones de casos y videos
educativos de interés y actualidad. Conozca más sobre esta publicación en el sitio
https://grupogiddet.wixsite.com/casos o al escanear el código QR.