bluuebunny/crossref_metadata_2025 huggingface dataset:
Growth Response and Yield of Pagoda Mustard Plant (Brassica narinosa) Due to Concentration and Time Interval of Liquid Bokashi Administration of Rice Washing Water
Authors: Suyani Ida Sugeng , Zuhroh Mimik Umi
Published: January 2023

The purpose of this study was to determine the growth response and yield of pagoda mustard (Brassica narinosa) due to the concentration and time interval for applying liquid bokashi to rice washing water. The research was conducted from December 2019 to February 2020 in Lumbang Village, Lumbang District, Probolinggo Regency. This study used a factorial randomized block design method with two factors, namely concentration and time interval for giving liquid bokashi rice washing water 3 times. The treatment consisted of 2 factors. The first factor is the concentration of liquid bokashi rice washing water (K), namely: K0 = 0% (control/without giving liquid bokashi. The second factor is the time interval for giving liquid bokashi (L). Observation variables consist of plant height (cm), number of leaves (fruit), leaf area (cm2), wet stover weight (g), dry stover weight (g), root length (cm), In this study using a linear model. Data will be analyzed by means of the F test, If the factor variance If there is a significant effect on the interaction, it is tested with 5% DMRT. The conclusions of this study are 1). The concentration of liquid bokashi had a significant effect on the parameters of plant height, number of leaves, leaf area, wet stover weight, dry stover weight and root length, 2). The time interval for bokashi administration had no significant effect on all observation parameters, 3). administration of liquid bokashi and time interval of administration on the growth and yield of pagoda mustard in almost all observed parameters.
La tradición cadavérica en la historia del arte y sus ecos en la obra de Joel-Peter Witkin
Authors: Navas Fernández Alexis
Published: January 2023

El presente artículo tiene como objetivo analizar el tratamiento del cadáver, y sus fragmentos, dentro de la producción fotografía de Joel-Peter Witkin.  Estableciendo líneas de conexión con las Artes Plásticas del Pasado y reflexionando sobre los aportes que se producen al tema del Memento Mori y la Vanitas desde una perspectiva contemporánea.
ASYMMETRIC IMPACTS OF MONETARY POLICY SHOCK ON OUTPUT GAP: EVIDENCE FROM REGIONS IN INDONESIA
Authors: Triwibowo Sugeng , Oktaviani Defy
Published: January 2023

We examine the impact of the monetary policy on regional output gaps across 33 Indonesian provinces. Heterogeneous regional responses of the output gap to monetary policy shock are captured using the Vector Autoregressive model. Moreover, the idiosyncratic variations across provinces accounted for different responses are observed with the spatial econometric model. The spatial analysis suggests that economic structure and financial depth positively and significantly determine the aforesaid asymmetric responses. On the other hand, economic size and trade openness have a negative impact on them.
NOWCASTING REGIONAL ECONOMIC GROWTH IN INDONESIA
Authors: Ringo Jesica Nauli Br. Siringo , Monika Anugerah Karta
Published: January 2023

This study aims to nowcast gross regional domestic product at the provincial level for Indonesia. The dynamic factor model and mixed data sampling were applied to three sets of variables; namely, macroeconomic, financial, and Google Trends. We find that both methods captured several economic expansions and contractions, including the recent downturn during the COVID-19 pandemic. By including the pandemic period, accuracy across the same set of variables and provinces was slightly reduced.
THE SYSTEMIC RISK IN THE GULF COOPERATION COUNCIL COUNTRIES’ EQUITY MARKETS AND BANKING SECTORS: A DYNAMIC COVAR APPROACH
Authors: Maghyereh Aktham , Virk Nader , Awartani Basel , Al Shboul Mohammad
Published: January 2023

This paper examines the systemic risk and its spillover between banking sectors of the Gulf Cooperation Council (GCC) region using the conditional value-at-risk framework. We construct country-specific banking indices using 11 large banks in the region that are systemically important (SIB). We report evidence of systemic risk spilloversfrom SIBs to the broad-based GCC market indices. The incremental tail spillovers are statistically significant for other domestic banks’ tail risk and inflate the systemic risk of cross-country GCC banks.
THE IMPACT OF DOMESTIC INVESTORS’ PARTICIPATION IN GOVERNMENT DEBT ON BANK LOANS TO THE PRIVATE SECTOR: A CROSS-COUNTRY STUDY
Authors: Adamanti Justina , Safuan Sugiharso , Husodo Zaafri Ananto
Published: January 2023

This study analyzes the impact of domestic investors’ participation in government debt on bank loans to the private sector in advanced and emerging countries. We find that domestic bank participation in government debt has a more profound negative impact on bank loans to the private sector in advanced than in emerging countries. Meanwhile, domestic non-bank participation in government debt only negatively impacts bank loans to private sector in emerging countries. While both domestic bank and non-bank participation in government debt have a negative impact on bank loans to the private sector in emerging countries, the latter has a weaker impact.
Rapid Respiratory Panel Testing for SARS-CoV-2: Experience in a Private Tertiary Hospital
Authors: Tamayo Steffanie Charlyne , Andal Jose Jasper , Madrid Manuelito , Lagamayo Evelina , Lo Raymundo , Ang Daphne
Published: January 2023

SARS-CoV-2 has infected more than 643 million individuals worldwide and accounts for close to 64,950 deaths in the Philippines. Due to COVID-19’s clinical overlap with other diseases and non-specific radiologic findings, its diagnosis rests primarily on laboratory methods, including reverse transcription polymerase chain reaction (RT-PCR) and multiplexed molecular platforms for rapid syndromic testing. Compared to RT-PCR which has a turnaround time of 24 to 72 hours, multiplexed molecular platforms can provide alternative diagnoses to COVID-19 in an average of one hour, providing meaningful data that can impact clinical and resource management when handling acute surge of patients with respiratory symptoms.
Unforeseen Metal Toxin Produced in Particulates of Wildland Fires
Authors: Fendorf Scott , Lopez Alandra , Lezama-Pacheco Juan
Published: January 2023

Accentuated by climate change, catastrophic wildfires are a growing, distributed global public health risk from inhalation of smoke and dust. An underrecognized health threat arises from altered naturally occurring metals originating in soils and plants. Here, we demonstrate that high temperatures during California wildfires catalyzed widespread transformation of chromium to its carcinogenic form in soil and ash, particularly in areas with metal-rich geologies. In wildfire ash, we observed dangerous levels of reactive hexavalent chromium in wind-dispersible particulates that persisted in surficial layers for up to a year post-fire. The geographic distribution of metal-rich soils and fire incidents illustrate the broad global threat of wildfire smoke- and dust-born metals to populations.
MSCs’ conditioned media cytokine and growth factor profiles and their impact on macrophage polarization
Authors: Peshkova Maria , Korneev Alexander , Suleimanov Shakir , Vlasova Irina I. , Svistunov Andrey , Kosheleva Nastasia , Timashev Peter
Published: January 2023

Background.
There is a growing body of evidence that multipotent mesenchymal stromal cells’ (MSCs’) remarkable therapeutic potential is attributed not only to their differentiation and regenerative capacity, but also to the paracrine effect, underlying their immunomodulatory properties. MSCs’ secretome (i.e., cytokines, growth factors, and extracellular vesicles) is therefore increasingly discussed in the context of their ability to modulate inflammatory response and promote regeneration. There is evidence that 2D or 3D culturing conditions have an impact on the cells’ secretome, and here we aimed to compare the secretion of cytokines and growth factors in human MSCs from different sources cultured in 2D and 3D conditions and assess their effect on human macrophages polarization in vitro.
Methods.
MSCs were derived from human adipose tissue, bone marrow, gingiva, placenta, and umbilical cord, cultured as monolayers or as cell spheroids. Their cytokine profiles were analyzed, and data standardization was carried out using a z-score. Human peripheral blood mononuclear cells-derived macrophages were then treated with umbilical cord-derived MSCs’ conditioned media and their effect on macrophages polarization was assessed.
Results.
Our findings suggest that umbilical cord-derived MSCs’ conditioned media demonstrated the highest cytokine and growth factor levels and despite mostly pro-inflammatory cytokine profile were able to promote human macrophages’ polarization to anti-inflammatory M2 state and inhibit their polarization to pro-inflammatory M1 state.
Conclusions.
Umbilical cord-derived MSCs’ conditioned media hold great potential for therapeutic use, demonstrating significant anti-inflammatory effect on human macrophages.
Uncertainty in non-CO2 greenhouse gas mitigation: Make-or-break for global climate policy feasibility
Authors: Harmsen Mathijs , Tabak Charlotte , Höglund-Isaksson Lena , Humpenöder Florian , Purohit Pallav , Vuuren Detlef van
Published: January 2023

Despite its projected crucial role in stringent, future global climate policy, non-CO2greenhouse gas (NCGG) mitigation remains a large uncertain factor that has received relatively little scientific attention. A revision of the estimated mitigation potential could have massive implications for the feasibility of global climate policy to reach the Paris Agreement climate goals. Here, we provide a systematic bottom-up estimate of the total uncertainty in NCGG mitigation, by developing “optimistic, default and pessimistic” long-term non-CO2marginal abatement cost (MAC) curves. The global 1.5-degree climate target is found to be out of reach under pessimistic MAC assumptions, as is the 2-degree target under high emission assumptions. MAC uncertainty translates into a large projected range in (all in a 2-degree scenario) relative NCGG reduction (40–58%), carbon budget (± 120 Gt CO2) and policy costs (± 16%). Partly, the MAC uncertainty signifies a gap that could be bridged by human efforts, but largely it indicates uncertainty in technical limitations.
An Iterative Capacity Dimensioning Scheme for Lte Advanced Networks Under Resource Constraints
Authors: Chandimal Nuwan , Wavegedara Chandika Bandara
Published: January 2023

The demand for mobile data has continued to grow exponentially over the last two decades or so, mainly due to the rapid proliferation of smart devices and high-quality video applications. Legacy voice-oriented networks (e.g., 2G networks) have now become obsolete. The fourth generation (4G) long term evolution (LTE) offers many improvements over the third generation (3G) High Speed Packet Access (HSPA). As of end 2021, 4G LTE has the widest population coverage globally among all the other mobile network technologies. However, there are yet a considerable number of countries with less than 60% 4G LTE coverage. Network dimensioning is an indispensable initial step in the radio network planning process. Dimensioning of LTE-A networks are more difficult and challenging compared to legacy networks due to different varieties of services offered with different quality of service (QoS) requirements. Even though mobile network operators are usually keen on adapting new technologies as soon as they can, they have limited investment capacities and are highly concerned about the maximum utilization of resources with a high return on investment (ROI). On the other hand, an under-dimensioned network may fail to cater for the user requirements. Thus, it is imperative to have an accurately
Assessment of dimethyl sulphide odorous emissions during coal extraction process in Coal mine Velenje
Authors: Uranjek Gregor , Horvat Milena , Milačič Radmila , Rošer Janez , Kotnik Jože
Published: January 2023

Underground coal extraction at Coal Mine Velenje occasionally gives rise to odour complaints from local residents.
This manuscript describes a robust quantification of odorous emissions of mine sources and a model-based analysis aimed to establish a better understanding of the sources, concentrations, dispersion, and possible control of odorous compounds during coal extraction process.
Major odour sources during underground mining are released volatile sulphur compounds from coal seam, that have characteristic malodours at extremely low concentrations at µg/m3 levels. Analysis of 1028 gas samples taken over a six-year period (2008-2013) reveal that dimethyl sulphide ((CH3)2S) is the major odour active compound present in the mine, being detected on 679 occasions throughout the mine. While hydrogen sulphide (H2S) and sulphur dioxide (SO2) were detected 5 and 26 times.
Analysis of gas samples has shown that main DMS sources in the mine are coal extraction locations at longwall faces and development headings and that DMS is releasing during transport from main coal transport system.
The dispersion simulations of odour sources in the mine have shown that the concentrations of DMS at median levels can represents relatively modest odour nuisance. While at peak levels the concentration of DMS remained sufficiently high to create an odour problem both in the mine and on the surface. Overall, dispersion simulations have shown that ventilation regulation on its own is not sufficient as an odour abatement measure.
Effects of temperature on soil geochemical properties and accumulation of heavy metals in rapeseed (Brassica napus)
Authors: Lee Sujung , Kim Kyoung-Woong
Published: January 2023

The global surface temperature is predicted to increase by 1.0°C to 5.7°C by the end of the twenty-first century from the Inter-governmental Panel on Climate Change (IPCC) report, but the effects of higher temperatures on soil properties and heavy metal accumulation in plants are unclear. To investigate the effects of soil temperature on soil geochemical properties and the accumulation of heavy metals in plants, we grew rapeseeds (Brassica napus) in pots filled with contaminated field soil at four different temperatures (22.5, 22.9, 23.7, and 24.6°C) in a controlled growth chamber. The concentration of heavy metals in the rapeseed samples at different temperatures showed a positive partial correlation coefficient with the soil temperatures. The order of partial correlation coefficients was Zn (0.50) > Cd (0.21) > Cu (0.19) > As (0.15) > Pb (0.13). However, only the Zn concentration in rapeseed showed a significant moderate positive correlation (r = 0.50, p < 0.01) with soil temperature. In terms of soil properties, soil pH positively correlated (r = 0.49, p < 0.01), whereas the cation exchange capacity (CEC) negatively correlated (r = -0.55, p < 0.001) with soil temperatures. These results suggest that increasing soil temperatures affect the plant metabolisms and soil geochemical properties and enhance the soil-to-plant transfer of heavy metals. Therefore, future global warming may lead to unforeseen losses in crop productivity and pollutant accumulation, consequently resulting in detrimental effects on the health of animals and human beings.
Flowering is the critical growth stage for adverse effects of salinity on the grain yield of sunflower
Authors: Mila Afrin Jahan , Bell Richard W. , Barrett-Lennard Edward G. , Kabir Enamul , Dell Bernard
Published: January 2023

Purpose Crop sensitivity to root zone salinity can vary over time during a cropping season, which can lead to severe damage when high sensitivity coincides with high soil salinity. The variation in salinity sensitivity of sunflower (Helianthus annuus L.) during its growth cycle is not known.
Methods Two pot experiments were conducted in sand culture with a complete nutrient solution to test the response of sunflower to salinity at different growth stages. Solutions were repeatedly flushed through pots in excess to maintain the specified salt concentrations in the soil solution. In Experiment 1, salt-sensitive growth stages were determined by applying solutions of increasing electrical conductivity (EC < 0.7, 2, 4 or 8 dS m-1) throughout vegetative, flowering or grain filling stages based on well-defined phenology. In Experiment 2, the most sensitive stage to root-zone salinity was determined by exposing the plants to 10-day periods of salinity (EC < 0.7, 8, 16 and 24 dS m-1) overlapping by 4 days starting from the 13-leaf to grain filling.
Results In both experiments, decreases in seed yield were associated with exposure of plants to elevated EC during the period when the disk flower was opening to ~95% anthesis, while grain filling was the least sensitive. In experiment 2, measurements of ion concentrations and rates of photosynthesis in leaves suggested that Na+ toxicity decreased yield due to decreases in the availability of photosynthates to flowers.
Conclusion To maximise sunflower yield in saline soils, crop management should minimise salinity stress from flower opening to anthesis.
Study protocol for a randomized controlled trial to determine the effectiveness of a mHealth application as a family supportive tool in pediatric otolaryngology perioperative process (TONAPP).
Authors: DOBRINA RAFFAELLA , Cassone Andrea , Cin Margherita Dal , Ronfani Luca , Giangreco Manuela , Schreiber Silvana , Starec Anja , Brunelli Laura , Brumatti Liza Vecchi , Bicego Livia
Published: January 2023

Background

While otorhinolaryngology (ORL) surgery is common in children, hospitalization, surgery, and post-discharge home management are stressful experiences for young patients and their family caregivers. Findings from literature highlight a lack of time in hospitals to support ORL surgery children and their caregivers in the perioperative process, along with the risks of caregivers’ autonomous web or social media resources investigation. Therefore, this study aims to evaluate the effectiveness of a mobile health application with contents to support ORL patients and their caregivers in the perioperative period to reduce caregivers’ anxiety and children distress compared to standard care.

Methods

An open two arm randomized control trial study design will be adopted. The intervention will consist of a mobile health application with contents to support ORL patients and their caregivers in the perioperative period. One hundred and eighty participants will be enrolled and randomly assigned to the experimental group that will have in use the m-health application or the control group. The control group will receive standard information and education about the ORL perioperative period by healthcare providers orally or through booklets. The primary outcome will be the difference between intervention and control group in preoperative caregiver state anxiety. Secondary outcome measures include children’s distress before surgery and family preparation for hospitalization.

Discussion

The results of the study will be critical for the implementation of a new and safe model for the management of care and education in paediatrics. In this model, organisational and health-related positive outcomes may be achieved by supporting continuity of care and empowering citizens for informed participation and satisfaction in paediatric health promotion and management.

Trial registration

Trial identifier: NCT05460689 registry name: ClinicalTrials.gov. Date of registration: July 15, 2022. Url: https://clinicaltrials.gov/ct2/show/NCT05460689?term=NCT05460689&draw=2&rank=1
Well-dispersed titanium dioxide and silver nanoparticles on external and internal surfaces of asymmetric alumina hollow fibers for enhanced chromium (VI) photoreductions
Authors: Costa Igor G. F. , Ribeiro Stella R.F.L. , Nascimento Lucas L. , Patrocinio Antonio Otavio T. , Cardoso Vicelma L. , Batista Fabiana R. X. , Reis Miria H. M.
Published: January 2023

Silver (Ag)-decorated titanium dioxide (TiO2) catalysts were produced under ultrasound irradiation at different loadings of Ag nanoparticles (from 5 to 50 wt%). Then, the catalysts were supported on internal and external surfaces of alumina hollow fibers with asymmetric pore size distribution. The produced catalysts were considered for Cr(VI) photoreductions. The ultrasound-assisted process potentialized the distribution of Ag nanoparticles on the TiO2 surface. The loading of Ag nanoparticles at concentrations greater than 5 wt% was necessary to improve the TiO2 activity for Cr(VI) photoreduction. The loading of Ag nanoparticles at 30 wt% improved the Cr(VI) photoreduction of the single TiO2 catalyst from 40.49 ± 0.98 to 55.00 ± 0.83% after 180 min of reaction. Suspended and supported Ag-decorated TiO2 catalysts achieved total Cr(VI) photoreduction after 21 h of reaction. The adjusted reaction rate constant with the externally supported Ag-TiO2 catalyst was 3.57x10-3 ± 0.18 x10-3 min-1. Similar reaction rate constants were achieved with suspended and internally supported catalysts (approximately 2.70x10-3 min-1). After 10 sequential reuses, all catalysts presented similar Cr(VI) photoreductions of approximately 66%. Nevertheless, the use of the externally supported catalyst is suggested for Cr(VI) photoreductions due to its superior catalyst activity at least in the first reuse cycles.
A critical review on phycoremediation of Pollutants from Wastewater – A Novel Algae Based Secondary Treatment with the Opportunities of Production of Value-Added Products
Authors: Sengupta Swagata Laxmi , Chaudhuri Rajib Ghosh , Dutta Susmita
Published: January 2023

Though the biological treatment employing bacterial strains has wide application in effluent treatment plant, it has got several limitations. Researches hence while looking for alternative biological organisms that can be used for secondary treatment came up with the idea of using microalgae. Since then, a large number of microalgal/cyanobacterial strains have been identified that can efficiently remove pollutants from wastewater. Some researchers also found out that the algal biomass not only acts as a carbon sink by taking up carbon dioxide from the atmosphere and giving oxygen but also is a renewable source of several value-added products that can be extracted from it for the commercial use. In this work, the cleaning effect of different species of microalgae/cyanobacteria on wastewater from varied sources along with the value-added products obtained from the algal biomass as observed by researchers during the past few years are reviewed. While a number of review works in the field of phycoremediation technology was reported in literature, a comprehensive study on phycoremediation of wastewater from different industries and household individually is limited. In the present review work, the efficiency of diverse microalgal/cyanobacterial strains in treatment of wide range of industrial effluents along with municipal wastewater having multi-pollutants has been critically reviewed.
A neighborhood comprehensive learning particle swarm optimization for the vehicle routing problem with time windows
Authors: Wu Qichao , Xia Xuewen , Song Haojie , Xu Xing , Zhang Yinglong , Yu Fei , Wu Hongrun
Published: January 2023

Vehicle routing problem with time windows (VRPTW), which is a typical NP-hard combinatorial optimization problem, plays an important role in modern logistics and transportation systems. Although the particle swarm optimization (PSO) algorithm exhibits very promising performance on continuous problems, how to adapt PSO to efficiently deal with VRPTW is still challenging work. In this paper, we propose a neighborhood comprehensive learning particle swarm optimization (N-CLPSO) to solve VRPTW. To improve the exploitation capability of N-CLPSO, we introduce a new remove-reinsert neighborhood search mechanism. We calculate an information matrix (IM) recording the probability of adjacency between two clients based on the information about the clients themselves and the local information about the elite individuals to guide the removal operation of the neighborhood search. At the same time, we combine the cost matrix (CM) that records the cost of customer removal with IM to create a guided reinsertion operator based on local information to guide the routing. Moreover, to enhance the exploration of N-CLPSO, a semi-random disturbance strategy is proposed. To
prevent degradation of the population, the longest common sequences of elites are saved when performing the disturbance. To illustrate the effectiveness of N-CLPSO, this paper conducts extensive experiments
Effect of Laser Irradiation and Rhizobium on Growth Parameters of Clover
Authors: Maher Khalid Ali , Ahmed Abd El-Rahman , Hassan Helmy , El-Raie Ahmed
Published: January 2023

This study aims to study the effect of different combinations of Laser or/and Rhizobium on the growth parameters of clover plants. To carry out this study, irradiation of seeds by laser radiation and seeds incubation by Rhizobium combination with laser exposure times 5, 10, and 15 minutes compared to untreated seeds were used. Growth plants were cut four times during the growing season every 40–45 days, then growth parameters were measured. Obtained results showed that using treated seeds by combination laser exposed for 5 minutes and Rhizobium gave higher growth parameters followed by 10 minutes and control. While the exposure time of 15 minutes was less value. By using Laser excised times or/and Rhizobium, the results indicated that the growth parameters values of cover plants at irrigated with fresh water were higher than clover plants irrigated with groundwater. So, the authors recommended to use of irridiation by Laser beam and/or incubation by Rhizobium of clover seeds or any different seeds crops in order to improve vegetation and productivity of crops.
Rapid oxidation of gasoline exhausts reveals marked impacts of transient conditions on potential of secondary organic aerosol production
Authors: Peng Jianfei , Zhang Jinsheng , Song Ainan , Lv Zongyan , Tong Hui , Du Zhuofei , Guo Jiliang , Wu Lin , Wang Ting , Hallquist Mattias , Mao Hongjun
Published: January 2023

Vehicle emission is a major source of atmospheric secondary organic aerosols (SOA). Driving condition is a critical influencing factor for vehicular SOA production, but few studies have revealed SOA production dependence on the rapidly-changing real-world driving conditions. Here, a fast-response oxidation flow reactor system is developed and deployed to quantify the SOA formation potential under transient driving conditions. Results show that the SOA potential varies by orders of magnitude, e.g., 20-1500 mg kg-fuel-1 and 12–155 mg kg-fuel-1 for China V and China VI vehicles, respectively. High speed, acceleration, and deceleration are found to considerably promote SOA production due to higher organic gaseous emissions caused by unburned fuel emission or incomplete combustion. In addition, China VI vehicles significantly reduce SOA potential, yield, and acceleration and deceleration peaks. Our study provides experimental insight into vehicular SOA formation under transient driving conditions, which would benefit high-time-resolved SOA simulations in the urban atmosphere.
WITHDRAWN: Bifurcation scenarios in the hardware-in-the-loop experiments of highly interrupted milling processes
Authors: Toth Rudolf R. , Stepan Gabor
Published: January 2023

Hardware-in-the-loop (HIL) measurements of highly interrupted milling processes were conducted. A real spindle was used with a dummy tool on which the cutting forces were emulated with contactless sensors and actuators. During the experiments, Hopf- and period-doubling bifurcations were identified. The nonlinear dynamics of these period-doubling bifurcations are analyzed for a discrete model of highly-interrupted milling. This investigation found the bifurcation to be subcritical, which draws the attention to the limited practical validity of linear stability analysis.
Content Analysis of YouTube Videos Regarding Natural Disasters in India and Analysis of Users Sentiment through Viewer Comments
Authors: Rout Lulu , Acharya Manoj Kumar , Acharya Shubhasmita
Published: January 2023

This research investigates the ease with which people in India can access natural disaster videos on YouTube with the goal of raising awareness and empowering the general populace to take action for their own safety. The article describes the most common category of calamity for which videos were produced in India. The comments added by viewers in each video's comment area are analyzed in order to determine the viewers' intentions and feelings in relation to the available videos. This is done so in order to analyze viewers' sentiments. For this reason, study makes use of Webometric analyzer to retrieve the pertinent information from YouTube by utilizing the YouTube API key. Furthermore, the R-studio environment was utilized in order to do the sentiment analysis. After the raw data have been collected, they go through a process of manual verification so that the legitimacy and accuracy of the data may be confirmed. Following the application of the criteria for elimination, there were a total of 467 relevant movies and 20689 comments that were retrieved for further examination. Following a comprehensive investigation, it was discovered that the majority of films were published between the years of 2008 and 2010. When looking at the total amount of videos released on the topic of natural disasters in India, the most notable channels are INDIA TODAY, WION, and NDTV, among others. These channels have the most footage available online. Using the keyword analysis that was performed on the videos' titles, it was discovered that the majority of the movies in the collection were about cyclones, rather than any of the other kinds of natural disasters that can be found in India.
The transcription factor Zeb1 controls homeostasis and function of type 1 conventional dendritic cells
Authors: Wang Yan , zhang quan , He Tingting , Wang Yechen , Lu Tianqi , Wang Zengge , Lin Shen , Yang Kang , Wang Xinming , Xie Jun , Zhou Ying , Hong Yazhen , Liu Wen-Hsien , Mao Kairui , Cheng Shih-Chin , Chen Xin , Li Qiyuan , Xiao Nengming
Published: January 2023

Type 1 conventional dendritic cells (cDC1s) are the most efficient cross-presenting cells that induce protective cytotoxic T cell response. However, the regulation of their homeostasis and function is incompletely understood. Here we observed a selective reduction of splenic cDC1s in mice with Zeb1 deficiency in dendritic cells, due to excessive cell death, rendering mice higher resistance to Listeria infection. Moreover, cDC1s from other sources of Zeb1-deficient mice displayed impaired cross-presentation of exogenous antigens, resulting in compromised antitumor CD8+ T cell responses. Mechanistically, Zeb1 facilitated the production of phagosomal reactive oxygen species by repressing the expression of microRNA-96 that targeted Cybb mRNA of NADPH oxidase Nox2. Consequently, loss of Zeb1 in cDC1s diminished phagosomal membrane rupture that permits antigen export to the cytosol. Cybb re-expression in Zeb1-deficient cDC1s fully restored the defective cross-presentation while microRNA-96 overexpression in Zeb1-sufficient cDC1s inhibited cross-presentation. Therefore, our results identify a novel Zeb1-microRNA-96-Cybb pathway that controls cross-presentation in cDC1s and uncover an essential role of Zeb1in cDC1 homeostasis.
Changes in self-harm and suicide in California from 2017-2021: a population-based study
Authors: Lund Julia J. , Tomsich Elizabeth , Schleimer Julia P. , Pear Veronica A.
Published: January 2023

Background: Self-harm and suicide are major public health problems with immediate and long-term effects on individuals, families, and communities. In 2020 and 2021, stressors wrought by the COVID-19 pandemic, stay-at-home mandates, economic turmoil, social unrest, and growing inequality likely modified risk for self-harm. The coinciding surge in firearm purchasing may have increased risk for firearm suicide. In this study, we examined changes in counts and rates of fatal and nonfatal intentional self-harm in California across sociodemographic groups during the first two years of the COVID-19 pandemic relative to prior years.Methods:We used California-wide death data and University of California (UC)-wide hospital data to summarize fatal and nonfatal instances of intentional self-harm across race/ethnicity, age, education, gender, region, and method of harm. We compared case counts and rates in 2020 and 2021 with 2017-2019 averages.Results: Suicide decreased overall in 2020 (4123 deaths; 10.5 per 100,000) and 2021 (4104; 10.4 per 100,000), compared to pre-pandemic (4484; 11.4 per 100,000). The decrease in counts was driven largely by males, white, and middle-aged Californians. Conversely, Black Californians and young people (age 10-19) experienced increased burden and rates of suicide. Firearm suicide also decreased following the onset of the pandemic, but relatively less than overall suicide; as a result, the proportion of suicides that involved a firearm increased (from 36.1% pre-pandemic to 37.6% in 2020 and 38.1% in 2021). Females, people aged 20-29, and Black Californians had the largest increase in the likelihood of using a firearm in suicide following the onset of the pandemic. Counts and rates of nonfatal, intentional self-harm in UC hospitals increased in 2020 (2160; 30.7 per 100,000) and 2021 (2175; 30.9 per 100,000) compared to pre-pandemic (2083; 29.6 per 100,000), especially among young people (age 10-19), females, and Hispanic Californians.Conclusions: The COVID-19 pandemic and co-occurring stressors coincided with heterogeneous changes in risk of self-harm and suicide across the California population. Marginalized racial groups, females, and younger people experienced increased risk for self-harm, particularly involving a firearm. Public health intervention and policy action are necessary to prevent fatal and nonfatal self-harm injuries and reduce related inequities.
Clinical outcome comparison between transjugular intrahepatic portosystemic shunt and endoscopic treatment in patients with cavernous transformation of the portal vein presenting with variceal bleeding: A retrospective study
Authors: Tong Yaru , Zhang Ming , Zhang Feng , Xiao Jiangqiang , Wang Yi , Zhang Wei , Huang Shuling , Peng Chunyan , Zhuge Yuzheng , Zhang Bin
Published: January 2023

Background: Cavernous transformation of the portal vein (CTPV) is often associated with portal hypertension and varicose bleeding. Endoscopic treatments (ETs) and transjugular intrahepatic portosystemic shunts (TIPS) can be able to prevent rebleeding in patients with CTPV. This study aimed to compare the clinical outcomes of TIPS and ET in patients with CTPV presenting with variceal bleeding.
Methods: We reviewed the data of patients with portal cavernous transformation presenting with variceal bleeding in Nanjing Drum Tower Hospital from February 2014 to January 2021, which included 38 patients who underwent endoscopic treatment and 25 patients who underwent TIPS therapy.
Results: During the follow-up period, the upper gastrointestinal rebleeding rate and survival rate have no significant difference between the ET group and TIPS group (P ＞0.05). The median hospitalization cost in the TIPS group ( 93258.00 Chinese Yuan) was significantly higher than that in the ET group (47109.00 Chinese Yuan) (P = 0.001), and the length of hospital stay in the TIPS group ( 14.52 ± 12.00 days) was much shorter than that in the ET group ( 23.05 ± 12.87 days) (P = 0.003). The incidence of OHE in the TIPS group was higher than that in the ET group (P = 0.013).
Conclusions: For patients with CTPV presenting with variceal bleeding, TIPS was not superior to ET regarding preventing rebleeding and long-term survival. ET, rather than TIPS, may be a better choice for patients with CTPV presenting with variceal bleeding regarding medical expenses and postoperative complications.
Protein disulfide isomerase gene family and its potential function on Endoplasmic Reticulum quality control in Diatom Phaeodactylum tricornutum
Authors: Du hua , liu Xiaojuan , Ma Wanying , Chen Jichen , Liu Zidong , Du Hong
Published: January 2023

PDI was a molecular chaperone and played an important role in Endoplasmic Reticulum quality control (ERQC). PDI chaperone participated in the refolded of the misfolded/ unfolded proteins to maintain the cellular homeostasis under different stresses. However, bioinformatic characteristics and potential functions of PtPDIs in diatom Phaeodactylum tricornutum were still unknown so far. Hence, the genome-wide characterization of PtPDI proteins in P. tricornutum was firstly studied via bioinformatic and transcriptomic methods. Totally, 42 PtPDI genes were identified from the genome of P. tricornutum. The motifs, protein structure, classification, the number of introns-exons, phylogenetic relationship, and the expression level of 42 PtPDI genes under the tunicamycin stress were analyzed. The PtPDI genes in P. tricornutum were divided into three individual branches, indicating different evolutional relationships of these PtPDIs. The 14 up-regulated PtPDI genes under the tunicamycin treatment might have a positive effect on the ER quality control of the unfolded/ misfolded proteins, while the 7 down-regulated PtPDIs might negative effect the ERQC. Anyway, the important functions of PtPDIs in the ERQC of P. tricornutum still need more experiments to clarify. The study here provides a comprehensive understanding of the genome wide PtPDIs gene family and will be important for the functional study of PtPDIs in the ERQC.
Exceptional multi-year prediction skill of the Kuroshio Extension in a high-resolution decadal prediction system
Authors: Kim Who , Yeager Stephen , Danabasoglu Gokhan , Chang Ping
Published: January 2023

The Kuroshio Extension (KE) has far-reaching influences on climate as well as on local marine ecosystems. Thus, skillful multi-year to decadal prediction of the KE state and understanding sources of skill are both societally important and scientifically challenging. Retrospective forecasts using a high-resolution coupled system at an eddy-rich (0.1°) ocean and 0.25° atmosphere horizontal resolution show exceptional skill in predicting decadal KE variability up to lead year 4, substantially higher than the skill found in a similarly configured low-resolution (~1° for all components) system. The exceptional skill is attained because the high-resolution prediction system can more realistically simulate the westward propagation of initialized SSH anomalies in the central North Pacific and their expression within the sharp KE front. These results argue for the use of high-resolution models for future studies that aim to predict changes in the western boundary current systems and associated biological fields.
Urinary titin is not an early biomarker of skeletal muscle atrophy induced by muscle denervation in mice
Authors: Tanihata Jun , Minamisawa Susumu
Published: January 2023

Early detection of skeletal muscle atrophy is important to prevent further muscle weakness. However, there are few non-invasive biomarkers for skeletal muscle atrophy. Recent studies have reported that the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, is detected in the urine of patients with muscle damage. In this study, we hypothesized that urinary N-titin would be a potential early biomarker of skeletal muscle atrophy in mice caused by sciatic nerve denervation. Male mice were randomly divided into control and denervation groups, and urinary N-titin levels were assessed daily for 9 days using an enzyme-linked immunosorbent assay system. Despite reduced titin protein levels in atrophic muscles 10 days after denervation, cleaved N-titin fragments were not increased in the urine of mice with denervation-induced muscle atrophy. Furthermore, we found no uptake of Evans blue dye from the extracellular space into the cytoplasm in atrophic muscles, suggesting that the sarcomeric membrane is intact in those muscles. The present results suggest that cleaved N-titin in the urine is not suitable as an early biomarker of skeletal muscle atrophy.
Analyzing the digital divide among the demographics in the State of Telangana with reference to adoption of Digital Banking services.
Authors: M John Paul
Published: January 2023

The digitalisation of banking services is certainly a positive note that reduces the fatigue of the customers by operating their transactions through their mobile gadgets and other electronic instruments using the internet. However, the research literature demonstrates that Digital initiatives not only has positive connotation but has created a digital divide among the demographics across the communities (Benda et al, 2011) the studies also show evidence that there exists a huge gap among age groups, gender, income levels and socio-cultural groups in availing digital technologies in financial,especially the banking sector (Upadhyaya, L., et al, 2018). The present study is an attemptwhich focuses on understanding the changing and existing phenomenon of banking with special reference to Digitalisation and the adoption process of these new technologies by customers. The study mainly takes the constructs from Technology acceptance Models to test whether there exists any digital divide among the demographics in the study.
A population of faint, old, and massive quiescent galaxies at 3 < z < 4 revealed by JWST NIRSpec Spectroscopy
Authors: NANAYAKKARA THEMIYA , Glazebrook Karl , Jacobs Colin , Schreiber Corentin , Brammer Gabriel , Esdaile James , Kacprzak Glenn , Labbe Ivo , Lagos Claudia , Marchesini Danilo , Marsan Cemile , Nateghi Hasti , Oesch Pascal , Papovich Casey , Remus Rhea-Silvia , Tran Kim-Vy
Published: January 2023

The confirmation of the presence of very massive quiescent galaxies at epochs
only 1–2 Gyr after the Big Bang [1–8] has challenged models of cosmology and
galaxy formation [9]. Producing sufficient numbers of these requires abundant
numbers of the host dark matter halos to have been assembled and sufficient
time for star formation to proceed extremely quickly and then cease just as
rapidly. Ground-based spectroscopy has suggested ages of 200–300 Myr[3] at
redshifts 3 < z < 4. The true number and ages of these objects have however
been highly uncertain as ground-based spectra has been limited to the bright-
est of them [e.g. 3, 5], at wavelengths ∼ 2μm, which introduces a signficant
potential bias towards younger objects [7]. The launch of the James Webb
Space Telescope (JWST) enables dramatically more sensitive and constraining
spectroscopic observations due to the very low sky background, sharp image
quality, and access to wavelengths beyond 2μm. Here we report JWST NIR-
Spec [10] (0.6–5.3μm) observations of five new quiescent galaxy candidates
that were beyond the limit of previous ground-based spectroscopy. The high
signal:noise spectra of galaxies with continuum significantly fainter than ear-
lier confirmations show that they are also at redshifts 3 < z < 4, and that they
have substantial stellar masses of ∼ 0.5−1.2×1011 M⊙ comparable to massive
galaxies in the nearby Universe. One of the galaxies has been quenched for ∼> 1
billion years pointing to a presence of substantially older and fainter galaxies
than those revealed so far by ground-based spectroscopy. This suggests that
some of the massive galaxies have very early formation epochs (during the
epoch of reionization, z ∼> 6) pointing to a need for high conversion rates of
baryons to stars in the first massive galaxy halos in the early Universe [11, 12].
Knowledge-based mechanistic modeling accurately predicts disease progression with gefinitib in EGFR-mutant lung adenocarcinoma
Authors: L'Hostis Adèle , Palgen Jean-Louis , Perrillat-Mercerot Angélique , Peyronnet Emmanuel , Jacob Evgueni , Bosley James R. , Duruisseaux Michaël , Toueg Raphaël , Lefèvre Lucile , Kahoul Riad , Ceres Nicoletta , Monteiro Claudio
Published: January 2023

Lung adenocarcinoma (LUAD) is associated with a low survival rate at advanced stages. Although the development of targeted therapies has improved the survival of LUAD patients with identified and specific genetic alterations, such as mutations on the epidermal growth factor receptor (EGFR), the emergence of tumor resistance remains a threat to patient survival and calls for the development of new therapies. In this paper, we present the In Silico EGFR mutant LUAD (ISELA) model that links patients’ individual characteristics, including tumor genetic heterogeneity, to tumor size evolution and tumor progression over time under first generation EGFR-tyrosine kinase inhibitor gefitinib. This translational mechanistic model gathers extensive knowledge on LUAD and was calibrated on multiple scales, including in vitro, human tumor xenograft mouse and human, reproducing more than 90% of the experimental data identified. Moreover, with 98.5% coverage and 99.4% negative log rank tests, the model accurately reproduced the time to progression from the Lux-Lung 7 clinical trial, which was unused in calibration, thus supporting the model high predictive value. Therefore, this knowledge-based mechanistic model could be a valuable tool to support the development of new therapies against EGFR mutant LUAD as a foundation for the generation of synthetic control arms based on mechanistic models.
Use of the Bayesian statistics and the product of probabilities in the ionizing radiation field
Authors: Castillo Terman Frometa , Pyakuryal Anil , Narayanasamy Ganesh , Mesbahi Asghar
Published: January 2023

Nowadays, the probability of the intersection (PI) of two or more stochastic events or processes is calculated as the product of probabilities (PPs). The Bayes’ theorem (BT) is widely used in the ionizing radiation field. We will show the PI is not only obtained as the PPs; but the minimum of their probabilities; and demonstrate that terms P(B|A) and P(A|B) in the BT are not new probabilistic metrics, but the own respective probabilities of B and A events. Mathematical derivations based on strong probabilistic foundations, and with their respective illustrations were our methodology. There are demonstrations of: 1) The two ways for determining the PI; and 2) Incoherencies of the BT. The tumor control probability (TCP) and normal tissue non-complication probability (NTCP0) of the radiation oncology treatments to patients with more than one target, calculated respectively as the product of TCP, and NTCP0 of each treatment, are excellent-practical examples in the determination of the PI using PPs. Given previously explained conditions of the BT terms; the use of this theorem should be re-considered. The current determination of the PI using the PPs is not valid for stochastic variables belonging to a stochastic event or process.