bluuebunny/crossref_metadata_2025 huggingface dataset:
Genomic Signatures of Reinforcement
Authors: Garner Austin , Goulet Benjamin , Farnitano Matthew , Molina-Henao Y. , Hopkins Robin
Published: April 2018

Reinforcement is the process by which selection against hybridization increases reproductive isolation between taxa. Much research has focused on demonstrating the existence of reinforcement, yet relatively little is known about the genetic basis of reinforcement or the evolutionary conditions under which reinforcement can occur. Inspired by reinforcement’s characteristic phenotypic pattern of reproductive trait divergence in sympatry but not in allopatry, we discuss whether reinforcement also leaves a distinct genomic pattern. First, we describe three patterns of genetic variation we expect as a consequence of reinforcement. Then, we discuss a set of alternative processes and complicating factors that may make the identification of reinforcement at the genomic level difficult. Finally, we consider how genomic analyses can be leveraged to inform if and to what extent reinforcement evolved in the face of gene flow between sympatric lineages and between allopatric and sympatric populations of the same lineage. Our major goals are to understand if genome scans for particular patterns of genetic variation could identify reinforcement, isolate the genetic basis of reinforcement, or infer the conditions under which reinforcement evolved.
Hesitant Fuzzy Linguistic Preference Utility Set and Its Application in Selection of Fire Rescue Plans
Authors: Liao Huchang , Si Guangsen , Xu Zeshui , Fujita Hamido
Published: April 2018

Hesitant fuzzy linguistic term set provides an effective tool to represent uncertain decision information. However, the semantics corresponding to the linguistic terms in it cannot accurately reflect the decision-makers’ subjective cognition. In general, different decision-makers’ sensitivities towards the semantics are different. Such sensitivities can be represented by the cumulative prospect theory value function. Inspired by this, we propose a linguistic scale function to transform the semantics corresponding to linguistic terms into the linguistic preference values. Furthermore, we propose the hesitant fuzzy linguistic preference utility set, based on which, the decision-makers can flexibly express their distinct semantics and obtain the decision results that are consistent with their cognition. For calculations and comparisons over the hesitant fuzzy linguistic preference utility sets, we introduce some distance measures and comparison laws. Afterwards, to apply the hesitant fuzzy linguistic preference utility sets in emergency management, we develop a method to obtain objective weights of attributes and then propose a hesitant fuzzy linguistic preference utility-TOPSIS method to select the best fire rescue plan. Finally, the validity of the proposed method is verified by some comparisons of the method with other two representative methods including the hesitant fuzzy linguistic-TOPSIS method and the hesitant fuzzy linguistic-VIKOR method.
Support Needs and Experiences of People Bereaved by Suicide: Qualitative Findings from a Cross-Sectional British Study of Bereaved Young Adults
Authors: Pitman Alexandra , De Souza Tanisha , Khrisna Putri Adelia , Stevenson Fiona , King Michael , Osborn David , Morant Nicola
Published: April 2018

People bereaved by suicide are at increased risk of suicide, but evidence is lacking that available interventions reduce suicide risk. Few large-scale studies have described the views of suicide-bereaved people regarding their needs for support. Our objective was to explore the nature of young adults’ experiences of support after bereavement by suicide and their views on valued and unhelpful aspects. We conducted a cross-sectional study of staff and students aged 18–40 at 37 United Kingdom (UK) higher educational institutions in 2010, eliciting qualitative responses to two questions probing experiences of support and unmet needs after the suicide of a close contact. We conducted thematic analysis of responses from 420 adults bereaved by suicide, of whom 75% had received support after the loss. We identified three broad descriptive areas corresponding to important aspects of support: value and experiences of the support received; views on specific support needs; and reasons for not seeking support. We found that needs for emotional support exist throughout the social networks of people who die by suicide but are often hidden. Our findings suggest a need for proactive offers of support from family, friends, and professionals after suicide, repeated regularly in case a bereaved person does not feel ready for support early on.
In Vitro Influence of Extracts from Snail Helix aspersa Müller on the Colon Cancer Cell Line Caco-2
Authors: Matusiewicz Magdalena , Kosieradzka Iwona , Niemiec Tomasz , Grodzik Marta , Antushevich Hanna , Strojny Barbara , Gołębiewska Małgorzata
Published: April 2018

Colorectal cancer is the third most widely diagnosed cancer. Extracts from snails may modulate growth and development of colorectal cancer cells. The objective of this study was to determine the chemical composition of tissues derived from Helix aspersa Müller and red-ox properties of tissue extracts. Then, the influence of extracts and their fractions of different molecular weights on viability of Caco-2 cells was examined. Tissue lyophilisates contained antioxidants that could be important in the prevention of colorectal cancer. Moreover, we confirmed the presence of a wide array of compounds that might be used in treatment of this disease. The decrease of cell viability after the application of extracts from lyophilized mucus and foot tissues was affirmed. The effect of extract from mucus could be related to the content of some proteins and peptides, proper essential amino acids (EAA)/non-essential amino acids (NEAA) ratio, Met restriction and the presence of Cu, Ca, Zn, Se. The influence of the extract from foot tissues could be assigned additionally to the presence of eicosapentaenoic, α-linolenic, linoleic and γ-linolenic acids. The opposite effect was demonstrated by extract from lyophilized shells which increased cell viability. Further studies are needed to know whether dietary supplying of H. aspersa Müller tissues can be used as an approach in colorectal cancer management.
Non-Metastatic Cutaneous Melanoma Induces Chronodisruption in Central and Peripheral Circadian Clocks
Authors: De Assis Leonardo , Moraes Maria , Magalhães-Marques Keila , Kinker Gabriela , Da Silveira Cruz-Machado Sanseray , De Lauro Castrucci Ana
Published: April 2018

The biological clock has received increasing interest due to its key role in regulating body homeostasis in a time-dependent manner. Cancer development and progression has been linked to a disrupted molecular clock; however, in melanoma, the role of the biological clock is largely unknown. We investigated the effects of the tumor on its micro- (TME) and macro-environments (TMaE) in a non-metastatic melanoma model. C57BL/6J mice were inoculated with murine B16-F10 melanoma cells and 2 weeks later the animals were euthanized every 6 h during 24 h. The presence of a localized tumor significantly impaired the biological clock of tumor-adjacent skin and affected the oscillatory expression of genes involved in light- and thermo-reception, proliferation, melanogenesis, and DNA repair. The expression of tumor molecular clock was significantly reduced compared to healthy skin but still displayed an oscillatory profile. We were able to cluster the affected genes using a human database and distinguish between primary melanoma and healthy skin. The molecular clocks of lungs and liver (common sites of metastasis), and the suprachiasmatic nucleus (SCN) were significantly affected by tumor presence, leading to chronodisruption in each organ. Taken altogether, the presence of non-metastatic melanoma significantly impairs the organism’s biological clocks. We suggest that the clock alterations found in TME and TMaE could impact development, progression, and metastasis of melanoma; thus, making the molecular clock an interesting pharmacological target.
Cell-Specific PEAR1 Methylation Studies Reveal a Locus that Coordinates Expression of Multiple Genes
Authors: Izzi Benedetta , Noro Fabrizia , Cludts Katrien , Freson Kathleen , Hoylaerts Marc F.
Published: April 2018

Chromosomal interactions connect distant enhancers and promoters on the same chromosome, activating or repressing gene expression. PEAR1 encodes the Platelet-Endothelial Aggregation Receptor 1, a contact receptor involved in platelet function and megakaryocyte and endothelial cell proliferation. PEAR1 expression during megakaryocyte differentiation is controlled by DNA methylation at its first CpG island. We identified a PEAR1 cell-specific methylation sensitive region in endothelial cells and megakaryocytes that showed strong chromosomal interactions with ISGL20L2, RRNAD1, MRLP24, HDGF and PRCC, using available promoter capture Hi-C datasets. These genes are involved in ribosome processing, protein synthesis, cell cycle and cell proliferation. We next studied the methylation and expression profile of these five genes in Human Umbilical Vein Endothelial Cells (HUVECs) and megakaryocyte precursors. While cell-specific PEAR1 methylation corresponded to variability in expression for four out of five genes, no methylation change was observed in their promoter regions across cell types. Our data suggest that PEAR1 cell-type specific methylation changes may control long distance interactions with other genes. Further studies are needed to show whether such interaction data might be relevant for the genome-wide association data that showed a role for non-coding PEAR1 variants in the same region and platelet function, platelet count and cardiovascular risk.
Dirty Water, Muddied Politics: Hybridisation of Local and National Opposition to Kumtor Mine, Kyrgyzstan
Authors: Horrocks-Taylor Joseph
Published: April 2018

From a Mongolian ‘super mine’ to China’s One Belt One Road, rapid infrastructural development is reforging Central Asia as an economic pivot of the future. Such development offers enticing economic benefits, but threatens fragile environments and local livelihoods. Due to the weakness of the state, the emphasis will be on citizens to hold developers accountable to their social and environmental pledges. Reports of political elites influencing the demands of popular protests call into question the ability of citizens to fulfil this function. This paper examines protest authenticity in Kyrgyzstan, focusing on an environmental social movement against Kumtor gold mine. We trace the emergence and evolution of the social movement, identifying the flexible discursive and scalar strategies it uses to achieve emphasis of the local level and relevance on the national scale. The discussion focuses on how national political saliency may incentivise elite involvement with social movements. This involvement can mask the local demands of the social movement, fixing the environmental problem as a national issue. It is crucial to understand the scalar dynamics of elite-protest interaction if Central Asian civil society is to hold future infrastructural developments to account.
Electrochemical Impedance and Polarization Corrosion Studies of Tantalum Surface Modified by DC Plasma Electrolytic Oxidation
Authors: Sowa Maciej , Simka Wojciech
Published: April 2018

Tantalum has recently become an actively researched biomaterial for the bone reconstruction applications because of its excellent corrosion resistance and successful clinical records. However, a bare Ta surface is not capable of directly bonding to the bone upon implantation and requires some method of bioactivation. In this study, this was realized by direct current (DC) plasma electrolytic oxidation (PEO). Susceptibility to corrosion is a major factor determining the service-life of an implant. Therefore, herein, the corrosion resistance of the PEO coatings on Ta was investigated in Ringer’s solution. The coatings were formed by galvanostatic anodization up to 200, 300 and 400 V, after which the treatment was conducted potentiostatically until the total process time amounted to 5 min. Three solutions containing Ca(H2PO2)2, Ca(HCOO)2 and Mg(CH3COO)2 were used in the treatment. For the corrosion characterization, electrochemical impedance spectroscopy and potentiodynamic polarization techniques were chosen. The coatings showed the best corrosion resistance at voltages low enough so that the intensive sparking was absent, which resulted in the formation of thin films. The impedance data were fitted to the equivalent electrical circuits with two time constants, namely R(Q[R(QR)]) and R(Q[R(Q[RW])]). The inclusion of W in the circuit helped to fit the low-frequency part of the samples PEO-ed at 400 V, hinting at the important role of diffusion in the corrosion resistance of the PEO coatings described in the research.
How Am I Driving? Using Genetic Programming to Generate Scoring Functions for Urban Driving Behavior
Authors: López Roberto , González Gurrola Luis , Trujillo Leonardo , Prieto Olanda , Ramírez Graciela , Posada Antonio , Juárez-Smith Perla , Méndez Leticia
Published: April 2018

Road traffic injuries are a serious concern in emerging economies. Their death toll and economic impact are shocking, with 9 out of 10 deaths occurring in low or middle-income countries; and road traffic crashes representing 3% of their gross domestic product. One way to mitigate these issues is to develop technology to effectively assist the driver, perhaps making him more aware about how her (his) decisions influence safety. Following this idea, in this paper we evaluate computational models that can score the behavior of a driver based on a risky-safety scale. Potential applications of these models include car rental agencies, insurance companies or transportation service providers. In a previous work, we showed that Genetic Programming (GP) was a successful methodology to evolve mathematical functions with the ability to learn how people subjectively score a road trip. The input to this model was a vector of frequencies of risky maneuvers, which were supposed to be detected in a sensor layer. Moreover, GP was shown, even with statistical significance, to be better than six other Machine Learning strategies, including Neural Networks, Support Vector Regression and a Fuzzy Inference system, among others. A pending task, since then, was to evaluate if a more detailed comparison of different strategies based on GP could improve upon the best GP model. In this work, we evaluate, side by side, scoring functions evolved by three different variants of GP. In the end, the results suggest that two of these strategies are very competitive in terms of accuracy and simplicity, both generating models that could be implemented in current technology that seeks to assist the driver in real-world scenarios.
Mechanical Behavior of Two Ferrite–Martensite Dual-Phase Steels over a Broad Range of Strain Rates
Authors: Liang Jiangtao , Zhao Zhengzhi , Wu Hong , Peng Chong , Sun Binhan , Guo Baoqi , Liang Juhua , Tang Di
Published: April 2018

The present study concerns the deformation and fracture behavior of two ferrite–martensite dual phase steels (FMDP660 and FMDP780) with different phase fractions subjected to different strain rate (0.001 s−1 to 1000 s−1) tensile testing. For both steels, the yield strength (YS) monotonically increased with strain rates, whereas the values of ultimate tensile strength (UTS), uniform elongation (UE) and post-uniform elongation (PUE) were maintained stable at the low strain rate range (0.001–0.1 s−1), followed by a significant increase with strain rate at high strain rate levels (0.1–1000 s−1). The FMDP780 steel with a higher fraction of martensite possessed a stronger strain rate sensitivity of tensile strength and elongation (UE and PUE) values at the high strain rate stage, compared with the FMDP660 sample. The change of UTS and UE with different strain rates and phase fractions was highly related to the strain hardening behavior, which was controlled by the dislocation multiplication in ferrite, as validated by transmission electron microscopy (TEM). The fracture surface of the two steels was characterized by dimpled-type fracture associated with microvoid formation at the ferrite–martensite interfaces, regardless of the strain rates. The change of the dimple size and PUE value of the two steels with strain rates was attributed to the effect of adiabatic heating during tensile testing.
The Merensky Cyclic Unit, Bushveld Complex, South Africa: Reality or Myth?
Authors: Hunt Emma , Latypov Rais , Horváth Péter
Published: April 2018

The Merensky Unit, Bushveld Complex, is commonly described using genetic terms such as “cyclic unit”, typically without careful consideration of the connotations. We suggest that this contributes to the debate on processes forming the unit. This study integrates an extensive field study with detailed petrographic and textural analyses of the Merensky Unit to determine whether it is a “cyclic unit” sensu stricto. The study indicates that the bulk of the platinum-bearing chromitite-feldspathic orthopyroxenite developed through heterogeneous nucleation and in situ growth during multiple replenishment events. The overlying leuconorite developed above a gradational boundary, reflecting mixing following replenishment by a relatively more evolved magma. The bulk of this unit also formed in situ. The uppermost poikilitic anorthosite formed above a distinct boundary through a subsequent injection of a plagioclase-saturated magma, which crystallised in situ. Processes of gravitational settling and local remobilisation of crystals cannot be discounted from contributing to the development of the unit. The final textures throughout the unit developed through pervasive textural equilibration, with extensive fluid-mediated textural equilibration forming the megacrystic feldspathic orthopyroxenite. The evidence for at least five replenishment events indicates that the Merensky Unit is not a cyclic unit; therefore, the genetic term, “Merensky Cyclic Unit”, is misleading and its use should be carefully considered in future work.
Extraction and Analysis of Gigantol from Dendrobium officinale with Response Surface Methodology
Authors: Zheng Siyan , Zhu Yingpeng , Jiao Chunyan , Shi Mengyao , Wei Lianping , Zhou Yang , Jin Qing , Cai Yongping
Published: April 2018

In order to optimize the extraction of gigantol from Dendrobium officinale, the influence of methanol concentration, ultrasonic temperature, and liquid ratio on extraction efficiency was analysed by the response surface analysis method. The results show that the extraction rate reached a maximum when the methanol concentration was 92.98%, the solid-liquid ratio was 27.2 mL/g, and the extraction temperature was 41.41 °C. The content of gigantol of Dendrobium officinale in leaves was significantly higher than that in stems, reaching 4.7942 μg/g. The content of gigantol in Dendrobium huoshanensis Fengdou was significantly higher than that of other species of Fengdou. This experiment has practical significance for improving the utilization rate of Dendrobium officinale, and provides a reference for the study of the pharmacological and biological activity of gigantol.
A Facile, One-Pot, Surfactant-Free Nanoprecipitation Method for the Preparation of Nanogels from Polyglycerol–Drug Conjugates that Can Be Freely Assembled for Combination Therapy Applications
Authors: Vossen Laura , Wedepohl Stefanie , Calderón Marcelo
Published: April 2018

A well-established strategy to treat drug resistance is the use of multiple therapeutics. Polymer-based drug delivery systems (DDS) can facilitate a simultaneous delivery of two or more drugs. In this study, we developed and synthesized a dendritic polyglycerol (PG) nanogel (NG) system that allows for free combination of different fixed ratios of active compound conjugates within a single NG particle. As a proof of concept, we synthesized NGs bearing the chemotherapeutic agent doxorubicin (DOX) and paclitaxel (PTX) in different ratios, as well as conjugated dye molecules. Our combination PG NGs were formed by simply mixing PG–drug/dye conjugates bearing free thiol groups with PG-acrylate in an inverse surfactant-free nanoprecipitation method. With this method we obtained PG-NGs in the size range of 110–165 nm with low polydispersity indices. Solubility of hydrophobic PTX was improved without the need for additional solubilizing agents such as polyethylene glycol (PEG). Interestingly, we found that our NGs made from PG-DOX conjugates have a high quenching efficiency for DOX, which could be interesting for theranostic purposes.
Synthesis of a Flexible Freestanding Sulfur/Polyacrylonitrile/Graphene Oxide as the Cathode for Lithium/Sulfur Batteries
Authors: Peng Huifen , Wang Xiaoran , Zhao Yan , Tan Taizhe , Bakenov Zhumabay , Zhang Yongguang
Published: April 2018

Rechargeable lithium/sulfur (Li/S) batteries have received quite significant attention over the years because of their high theoretical specific capacity (1672 mAh·g−1) and energy density (2600 mAh·g−1) which has led to more efforts for improvement in their electrochemical performance. Herein, the synthesis of a flexible freestanding sulfur/polyacrylonitrile/graphene oxide (S/PAN/GO) as the cathode for Li/S batteries by simple method via vacuum filtration is reported. The S/PAN/GO hybrid binder-free electrode is considered as one of the most promising cathodes for Li/S batteries. Graphene oxide (GO) slice structure provides effective ion conductivity channels and increases structural stability of the ternary system, resulting in excellent electrochemical properties of the freestanding S/PAN/GO cathode. Additionally, graphene oxide (GO) membrane was able to minimize the polysulfides’ dissolution and their shuttle, which was attributed to the electrostatic interactions between the negatively-charged species and the oxygen functional groups on GO. Furthermore, these oxygen-containing functional groups including carboxyl, epoxide and hydroxyl groups provide active sites for coordination with inorganic materials (such as sulfur). It exhibits the initial reversible specific capacity of 1379 mAh·g−1 at a constant current rate of 0.2 C and maintains 1205 mAh·g−1 over 100 cycles (~87% retention). In addition, the freestanding S/PAN/GO cathode displays excellent coulombic efficiency (~100%) and rate capability, delivering up to 685 mAh·g−1 capacity at 2 C.
Franciscan Prophets and the Inquisition (1226–1326)
Authors: Anderson C.
Published: April 2018

This paper examines how Franciscan apologetics and polemics over the status of St. Francis and the Rule of 1223 created a climate of inquisitorial suspicion over prophecy and prophetic claims.
Naked-Eye Detection of Glucose in Saliva with Bienzymatic Paper-Based Sensor
Authors: Santana-Jiménez Luis , Márquez-Lucero Alfredo , Osuna Velia , Estrada-Moreno Ivan , Dominguez Rocio
Published: April 2018

The high incidence of Diabetes Mellitus in low-income regions has promoted the development of low-cost alternatives to replace blood-based procedures. In this work, we present a bienzymatic paper-based sensor suitable for the naked-eye detection of glucose in saliva samples. The sensor was obtained by a stamping procedure and modified with chitosan to improve the colorimetric readout. The bienzymatic reaction of GOx-HRP coupled with 2,4,6-tribromo-3-hydroxy benzoic acid was applied for the detection of glucose within a range from 0 to 180 mgdL−1 in buffer and artificial saliva solutions. The visual readout was perceived by the naked eye and registered with an office scanner to evaluate the analytical performance. The results showed a limit of detection of 0.37 mgdL−1 (S/N = 3) with an R.S.D. of 1.69% and a linear range from 1 to 22.5 mgdL−1 with an R2 of 0.99235. The analysis of human saliva samples was performed without pre-processing, achieving recoveries from 92 to 114%. The naked-eye detection was evaluated under two different light settings, showing average recoveries of 108.58 and 90.65% for standard and low illumination. The proposed device showed potential for easy-to-use, sensitive, low-cost, fast, and device-free detection of salivary glucose suitable for untrained personnel operation and limited facilities.
Effects of Cable Sway, Electrode Surface Area, and Electrode Mass on Electroencephalography Signal Quality during Motion
Authors: Symeonidou Evangelia-Regkina , Nordin Andrew , Hairston W. , Ferris Daniel
Published: April 2018

More neuroscience researchers are using scalp electroencephalography (EEG) to measure electrocortical dynamics during human locomotion and other types of movement. Motion artifacts corrupt the EEG and mask underlying neural signals of interest. The cause of motion artifacts in EEG is often attributed to electrode motion relative to the skin, but few studies have examined EEG signals under head motion. In the current study, we tested how motion artifacts are affected by the overall mass and surface area of commercially available electrodes, as well as how cable sway contributes to motion artifacts. To provide a ground-truth signal, we used a gelatin head phantom with embedded antennas broadcasting electrical signals, and recorded EEG with a commercially available electrode system. A robotic platform moved the phantom head through sinusoidal displacements at different frequencies (0–2 Hz). Results showed that a larger electrode surface area can have a small but significant effect on improving EEG signal quality during motion and that cable sway is a major contributor to motion artifacts. These results have implications in the development of future hardware for mobile brain imaging with EEG.
Noise Source Visualization Using a Digital Voice Recorder and Low-Cost Sensors
Authors: Cho Yong
Published: April 2018

Accurate sound visualization of noise sources is required for optimal noise control. Typically, noise measurement systems require microphones, an analog-digital converter, cables, a data acquisition system, etc., which may not be affordable for potential users. Also, many such systems are not highly portable and may not be convenient for travel. Handheld personal electronic devices such as smartphones and digital voice recorders with relatively lower costs and higher performance have become widely available recently. Even though such devices are highly portable, directly implementing them for noise measurement may lead to erroneous results since such equipment was originally designed for voice recording. In this study, external microphones were connected to a digital voice recorder to conduct measurements and the input received was processed for noise visualization. In this way, a low cost, compact sound visualization system was designed and introduced to visualize two actual noise sources for verification with different characteristics: an enclosed loud speaker and a small air compressor. Reasonable accuracy of noise visualization for these two sources was shown over a relatively wide frequency range. This very affordable and compact sound visualization system can be used for many actual noise visualization applications in addition to educational purposes.
Three-Dimensional Modeling of Weed Plants Using Low-Cost Photogrammetry
Authors: Andújar Dionisio , Calle Mikel , Fernández-Quintanilla César , Ribeiro Ángela , Dorado José
Published: April 2018

Sensing advances in plant phenotyping are of vital importance in basic and applied plant research. Plant phenotyping enables the modeling of complex shapes, which is useful, for example, in decision-making for agronomic management. In this sense, 3D processing algorithms for plant modeling is expanding rapidly with the emergence of new sensors and techniques designed to morphologically characterize. However, there are still some technical aspects to be improved, such as an accurate reconstruction of end-details. This study adapted low-cost techniques, Structure from Motion (SfM) and MultiView Stereo (MVS), to create 3D models for reconstructing plants of three weed species with contrasting shape and plant structures. Plant reconstruction was developed by applying SfM algorithms to an input set of digital images acquired sequentially following a track that was concentric and equidistant with respect to the plant axis and using three different angles, from a perpendicular to top view, which guaranteed the necessary overlap between images to obtain high precision 3D models. With this information, a dense point cloud was created using MVS, from which a 3D polygon mesh representing every plants’ shape and geometry was generated. These 3D models were validated with ground truth values (e.g., plant height, leaf area (LA) and plant dry biomass) using regression methods. The results showed, in general, a good consistency in the correlation equations between the estimated values in the models and the actual values measured in the weed plants. Indeed, 3D modeling using SfM algorithms proved to be a valuable methodology for weed phenotyping, since it accurately estimated the actual values of plant height and LA. Additionally, image processing using the SfM method was relatively fast. Consequently, our results indicate the potential of this budget system for plant reconstruction at high detail, which may be usable in several scenarios, including outdoor conditions. Future research should address other issues, such as the time-cost relationship and the need for detail in the different approaches.
An Azimuth Antenna Pattern Estimation Method Based on Doppler Spectrum in SAR Ocean Images
Authors: Meng Hui , Wang Xiaoqing , Chong Jinsong
Published: April 2018

In synthetic aperture radar (SAR) ocean remote sensing, it is very difficult to estimate an accurate azimuth antenna pattern (AAP) from low-scattering SAR images without strong scattering targets. Therefore, an azimuth antenna pattern estimation method based on Doppler spectrum in SAR ocean images is proposed in this paper. In order to preserve the complete AAP information, an azimuth unweighted matched filter is used to re-image the SAR raw data in the proposed method. Then, the shape factor of AAP can be obtained by linear statistics of the relationship between Doppler center and edge frequency spectrum in Doppler spectrum of each distance gate. In addition, the impact of the uniformity and signal-to-noise ratio of SAR ocean images on the estimation results are also analyzed by simulation. Finally, the feasibility of proposed method is verified by data from ERS-2 (European remote sensing satellite (ERS) was the European Space Agency’s first Earth-observing satellite). Experimental results show that the AAP estimated by proposed method has a good estimation result.
The Roots of the Religious Cold War: Pre-Cold War Factors
Authors: Kirby Dianne
Published: April 2018

The article is an examination of the roots of the amalgam of complex forces that informed the ‘religious cold war’. It looks at the near and the more distant past. Naturally this includes consideration of the interwar years and those of the Second World War. It also means addressing divisions in Christianity that can be traced back to the end of the third century, to the official split of 1054 between Catholic and Orthodox, the impact of the Crusades and the entrenched hostility that followed the fifty-seven years imposition on Constantinople of a Latin Patriarch. It surveys the rise of significant forces that were to contribute to, as well as consolidate and strengthen, the religious cold war: civil religion, Christian fundamentalism and the Religious Right. The article examines both western and eastern mobilization of national religious resources for political purposes.
Converting UN Sustainable Development Goals (SDGs) to Decision-Making Objectives and Implementation Options at the River Basin Scale
Authors: Ge Yingchun , Li Xin , Cai Ximing , Deng Xiangzheng , Wu Feng , Li Zhongyuan , Luan Wenfei
Published: April 2018

The Sustainable Development Goals (SDGs) of the United Nations cover all living things on Earth. However, downscaling the SDGs to regional scales for implementation is challenging. In the paper, we convert the general SDGs into tangible and actionable goals, targets and indicators for use in integrated river basin management (IRBM). Further, we propose a decision support framework that can be used to support IRBM implementation based on the SDGs. The framework offers a context for open thinking in which IRBM decision makers envision socioeconomic and ecosystem goals and the development tracks of a river basin and explore the various paths that can be followed to reach the goals. In particular, indicators are proposed for use in IRBM, which consider five aspects of river basins, specifically water, ecosystems, socioeconomic development, ability and data. To enable decision-making that promotes progress toward the goals, five scenarios, 17 sub-scenarios and 29 key parameters are provided that form a diverse set of scenarios corresponding to specific decision schemes. Moreover, these scenarios, sub-scenarios and parameters consider future uncertainties and both engineering and non-engineering measures that can be taken to achieve the co-development of human and natural factors in a basin.
A 10-Year Statistical Analysis of Heavy Metals in River and Sediment in Hengyang Segment, Xiangjiang River Basin, China
Authors: Tang Jingwen , Chai Liyuan , Li Huan , Yang Zhihui , Yang Weichun
Published: April 2018

Heavy metal elements in water and surface sediments were characterized in Hengyang river segment in Xiangjiang River basin, one of China’s most important heavy metal control and treatment region. Data of heavy metal monitoring results in water and sediment for 10 years were acquired from an environmental monitoring program in the main channel of the studied area. Descriptive and exploratory statistical procedures were performed to reveal the characteristics of the sample distributions of heavy metal elements. The sample distributions of heavy metal elements were largely skewed right. Data censoring and too severe rounding in the water monitoring data were identified to have caused discretization in the sample distributions. Temporal and spatial characteristics of the data sets were addressed. The chromium (Cr) in the sediment possessed unique behavior, and this could be caused by a rapid deposition and releasing process.
Estimated Dietary Intake of Trace Metals from Swordfish Consumption: A Human Health Problem
Authors: Barone Grazia , Dambrosio Angela , Storelli Arianna , Garofalo Rita , Busco Vito , Storelli Maria
Published: April 2018

Trace element (Hg, Pb, Cd, Zn, Cu, Ni, and Cr) occurrence was determined in the muscle tissue of swordfish collected in the Mediterranean Sea to assess whether the intakes complied with the recommended levels for essential metals and permissible levels for toxic elements. Metals were analyzed by an atomic absorption spectrophotometer (Shimadzu AA 7000). The methodology of Target Hazard Quotient (THQ) was also evaluated. The ranking order of toxic metal concentration was Hg > Cd > Pb, while for essential elements the distribution pattern followed the sequence Zn > Cu > Ni > Cr. The Estimated Weekly Intakes (EWI) as well as THQ for Cd and Pb indicated that swordfish consumption did not pose a risk to human health, whereas the major concern was for Hg. Fish size-related changes in Hg concentrations resulted in high EWI and THQ values relative to larger fish consumption, implying a potential risk to human health. For consumer protection, catches of swordfish approximately above 44 kg should be avoided as these fish have a higher risk of containing toxic levels of Hg.
Environmental justice concerns and the proposed Atlantic Coast Pipeline route in North Carolina
Authors: Wraight Sarah , Hofmann Julia , Allpress Justine , Depro Brooks
Published: April 2018

This report describes publicly available data sets and quantitative analysis that local communities can use to evaluate environmental justice concerns associated with pipeline projects. We applied these data and analytical methods to two counties in North Carolina (Northampton and Robeson counties) that would be affected by the proposed Atlantic Coast Pipeline (ACP). We compared demographic and vulnerability characteristics of census blocks, census block groups, and census tracts that lie within 1 mile of the proposed pipeline route with corresponding census geographies that lie outside of the 1-mile zone. Finally, we present results of a county-level analysis of race and ethnicity data for the entire North Carolina segment of the proposed ACP route. Statistical analyses of race and ethnicity data (US Census Bureau) and Social Vulnerability Index scores (University of South Carolina’s Hazards & Vulnerability Research Institute) yielded evidence of significant differences between the areas crossed by the pipeline and reference geographies. No significant differences were found in our analyses of household income and cancer risk data.
BALANCING PUBLIC AND PRIVATE INTERESTS THROUGH OPTIMIZATION OF CONCESSION AGREEMENT DESIGN FOR USER-PAY PPP PROJECTS
Authors: FENG Ke , WANG Shouqing , LI Nan , WU Chunlin , XIONG Wei
Published: April 2018

In user-pay public private partnership (PPP) projects, private sectors collect user fees to cover cost and reap revenue. For projects that cannot be self-financed, public sectors usually invest public funds to make them financially feasible. The concession agreement allocates revenues and risks, and lies in the center of balancing public and private interests. However, stakeholders may have contrary opinions regarding the optimization of concession agreement. While private sectors are concerned about earning money, public sectors pay more attention to the efficient use of public funds. To address this challenge, this paper firstly identifies several key concessionary items, including concession period, concession price, capital structure and government subsidy. Then, a multi-objective optimization model is presented using discounted cash flow method, in which key concessionary items act as decision variables and public and private interests are represented by two sub-objectives. Subsequently, the model is solved using non-dominated sorting genetic algorithm-II (NSGA-II). Furthermore, a numerical case based on Beijing No. 4 Metro Line is provided to demonstrate the application of the model. Results show that the proposed model can produce a series of viable combinations of concessionary items that balance public and private interests, which provides practical references for relative decision making activities.
Dispatch from the field II: the mystery of the red and blue Opadometa male (Araneae, Tetragnathidae, Opadometa sarawakensis)
Authors: Miller Jeremy , Freund Christian , Rambonnet Liselotte , Koets Lianne , Barth Nadine , van der Linden Corné , Geml József , Schilthuizen Menno , Burger Richard , Goossens Benoit
Published: April 2018

Males of Opadometa are difficult to associate with conspecific females, and sex-matching errors may persist in the taxonomic literature. Recommended best practices for definitive sex matching in this genus suggest finding a male in the web of a female, or better yet, mating pairs.

A male Opadometa was observed hanging on a frame line of the web of a female Opadometa sarawakensis, a species for which the male was previously undescribed. This occurred during a tropical ecology field course held at the Danau Girang Field Centre in Sabah, Malaysia. A taxonomic description was completed as a course activity.
A new species of Charinus (Amblypygi: Charinidae) from Ghana, with notes on West African whip spiders
Authors: Harms Danilo
Published: April 2018

The fauna of whip spiders (Amblypygi) in Western Africa is poorly known but probably diverse. Here, I describe the new speciesCharinuskakumsp. n.based on female morphology, and accompanied by DNA sequence data. The species is small and differs from other African species ofCharinusin the low number of pseudosegments on leg IV, female genital features, spination patterns of the pedipalp, and small body size. It was collected from wet tropical rainforest in Kakum National Park, Ghana and is only the fourth species ofCharinusto be recorded from the highly diverse Western African biodiversity hotspot. With a total body length of not even 6 mm it is also one of the smallest whip spiders in the world.
Mapping of nutrient regulating ecosystem service supply and demand on different scales in Schleswig-Holstein, Germany
Authors: Bicking Sabine , Burkhard Benjamin , Kruse Marion , Müller Felix
Published: April 2018

This study deals with one of the regulating ecosystem services, nutrient regulation. In order to guarantee sustainable land management, it is of great relevance to gain spatial information on this ecosystem service. Unsustainable land management with regard to nutrient regulation may, for example, result in eutrophication which has been identified as a major threat for the environmental state of our water bodies. In the first step of research, the potential supplies and demands of/for nutrient regulation were assessed and mapped at two different spatial scales: The German federal state of Schleswig-Holstein (regional scale) and the Bornhöved Lakes District (local scale). The assessment was undertaken for nitrogen, as an exemplary nutrient. Subsequently, potential supply and demand, combined with the nitrate leaching potential and the groundwater nitrate concentration, were incorporated into a correlation analysis. The data was statistically analysed with varying pre-processing and spatial resolutions. The statistical analysis reveals that large scale data with low resolution leads to more uncertain results. Decreasing the spatial scale and increasing the resolution of the data through a spatially more explicit assessment, leads to more explicit results. It is striking that the study reveals a spatial mismatch between the potential supply and demand for the ecosystem service nutrient regulation, which denotes unsustainable land management in the study areas.
Thermal and Viscoelastic Properties of Underfill Using hexagonal Boron Nitride (hBN) Nanofiller
Authors: Razgaleh S. A. , Aravamudhan Shyam
Published: April 2018

Epon 826 epoxy resin in conjunction with Epikure 3140 curing agent was used in this study to fabricate underfill composites. Nanofiller of 500nm hexagonal boron nitride (hBN) was incorporated in the underfill epoxy using ultrasonication technique to alter their thermal and viscoelastic properties. Filler contents ranging from 1% to 5% volume fraction (vol.%) were used to investigate changes in thermal behavior and viscoelasticity of underfill with an increase in filler loading. Thermal analysis has shown an increase in thermal conductivity of the underfill by increasing the filler loading. Using 5% vol.% of 500nm hBN nanofiller a thermal conductivity of 0.32 W/m.K was obtained as compared to neat epoxy with thermal conductivity of about 0.2 W/m.K, showing an enhancement in thermal conductivity of the underfill material. Furthermore, studying viscoelastic properties of fabricated underfills suggested the influence of filler and filler loading on viscoelasticity of underfill.
Fluorescent characterization of amyloid deposits in the kidneys of mdx mice
Authors: Gusel'nikova Valeriia , Antimonova Olga , Fedorova Elena , Shavlovsky Mikhail , Krutikov Aleksandr , Mikhailova Ekaterina , Gudkova Aleksandra , Mikhailov Vyacheslav , Korzhevskii Dmitry
Published: April 2018

Amyloidosis is a group of diseases that occurs when amyloid proteins are deposited in tissues and organs. The traditional way of identifying amyloid in tissue sections is staining with Congo red. However, this method has a number of limitations including background staining (background fluorescence), low fluorescence intensity and false-positive staining. Therefore, a complex of fluorescence-based methods should be applied to characterize tissue localization of amyloid deposits. The aim of this study was to identify amyloid deposits in the kidneys of dystrophin-deficient mdx mice using different fluorescent dyes. We examined 8 cases of renal amyloidosis in aged mdx mice. In all cases, we used traditional methods for amyloid detection (Congo red and Thioflavin T), as well as a new fluorescent dye, disodium salt of 2,7- (1-amino-4-sulfo-2-naphthylazo) fluorene (DSNAF). In our study, we confirmed the amyloid structure of protein deposits in kidneys of aging mdx mice by several fluorescence-based staining methods. We found that fixation method has profound effects on downstream staining procedures, and demonstrated that the application of specific fixative, zinc-ethanol-formaldehyde (ZEF), instead of traditional NBF allow to reduce the background fluorescence. We also illustrated the usefulness of novel fluorescent dye DSNAF for detection of amyloid deposits in mouse tissues. Our results confirmed the strong affinity and high specificity of this dye for amyloid fibrils. The verification of DSNAF for detecting amyloid in human tissues will provide a conclusion on the applicability of the developed staining method in clinical research practice.
Paroxysmal nocturnal hemoglobinuria: When delay in diagnosis and long therapy occurs
Authors: Mancuso Salvatrice , Sucato Giuseppe , Carlisi Melania , Santoro Marco , Tarantino Giuseppe , Iannitto Emilio , Napolitano Mariasanta , Siragusa Sergio
Published: April 2018

Paroxysmal nocturnal hemoglobinuria (PNH) is a rare clonal disorder characterized by hemolytic anemia, bone marrow failure and thrombosis, caused by a somaticmutation in PIG-A gene that results in theabsence of CD55 and CD59, two important complement regulatory proteins. In thispaper, a case of PNH is retrospectively examined looking for clinical and laboratory features, and the entire course of the disease from the onset of the symptoms isdescribed, together with an adequate follow-up over a 7-years treatment period. Inthis case, the not specificity and the limited clinical relevance of the symptoms led to adelay in diagnosis. After thrombosis, Eculizumab therapy has been shown to be effective, and during seven years of follow-up no events have occurred that put the patient’s life at risk. A multidisciplinary approach is crucial in cases like this, inorder to allow early diagnosis and minimize the risks for the patients.
Meningitis, Spondylodiscitis, Pneumonia and Septic Shock with Streptococcus pneumoniae in a Previously Healthy Woman with Isolated IgG2-, IgG3-, IgA-Deficiency and Monoclonal Gammopathy of Undetermined Significance
Authors: Gaini Shahin , Gudnason David , á Steig Bjarni , Nielsen Jenny Jónsdóttir
Published: April 2018

A 66 years old Caucasian woman with pneumococcal meningitis was treated and discharged after an uncomplicated course. Five months later she was readmitted withfever and right side abdominal pain and diagnosed with pneumococcal spondylodiscitis. One year later she was treated fora severe chest X-ray confirmed left lobar pneumonia. Two years later she was diagnosed with a pneumococcal pneumonia inher left lung with septic shock. An immunedeficiency screen revealed slightly reduced IgA levels, low IgG2 levels, low IgG3 levels and high IgG1 levels. No other immunedefects were identified. She did not respondserologically on vaccination with 13-valentconjugate and 23-valent polysaccharide pneumococcal vaccines. Further evaluations revealed a positive M-component inher blood and a bone marrow biopsy diagnosed her to have monoclonal gammopathy of undetermined significance. To protecther against future life threatening pneumococcal infections she was started on treatment with intravenous immunoglobulin. The case report illustrates the importance of thorough evaluation of patients with unusual infectious disease entities or unusual frequency of infections in individual patients. To optimize prophylactic measures and active treatment options in the individual patient, it is important to identify underlying causes of diseases and immune deficiencies that potentially can lead to life threatening infections. This is illustrated inour case by an undiagnosed monoclonal gammopathy of undetermined significancein an apparently healthy woman with atleast three life threatening documented pneumococcal infections in a two-year period and poor pneumococcal vaccine response