bluuebunny/crossref_metadata_2025 huggingface dataset:
FINITE ELEMENT ANALYSIS OF THE DIFFUSION MODEL OF THE BIOCLOGGING OF THE GEOBARRIER
Authors:   National University of Water and Environmental Engineering, Ulianchuk-Martyniuk Oksana V. , Michuta Olha R. , Ivanchuk, Natalia V.
Published: December 2021

The distribution of an organic chemical and the filtration process in the soil which contains a thin geochemical barrier are considered. Microorganism colonies develop in the presence of organic chemicals in the soil which leads to the so-called phenomenon of bioclogging of the pore space. As a result, the conductivity characteristics of both the soil as a whole and the geochemical barrier change. Conjugation conditions as a component of the mathematical model of chemical filtration in the case of inhomogeneity of porous media and the presence of fine inclusions were modified for the case of bioclogging. The numerical solution of the corresponding nonlinear boundary value problem with modified conjugation conditions was found by the finite element method. The conditions of the existence of a generalized solution of the corresponding boundary value problem are indicated. The results on the theoretical accuracy of finite element solutions are presented. Differences in the value of pressure jumps at a thin geochemical barrier were analyzed for the case considered in the article and the classical case on a model example of filtration consolidation of the soil in the base of solid waste storage. The excess pressure in 600 days after the start of the process reaches 25 % of the initial value when taking into account the effect of bioclogging, while is only 6 % for the test case disregarding the specified effect.
Advantages of Compound S-scan over Sectorial Scan or E-scan: A Case Study
Authors: Sundarraj Stephen
Published: December 2021

Within PAUT, inspectors have the option to apply various scanning techniques for performing weld inspections according to their configurations. These include the sectorial scan (S-scan) or a fixed-angle electronic scan (E-scan), or a combination of both called a compound S-scan. Compound S-scan, introduced around 2015 (Magruder 2016), has not been much explored, as not enough data can be extracted from the available resources to determine its effectiveness for inspection. Therefore, the author has taken a specific interest in studying this technique by comparing the available PAUT scanning techniques and providing options for selecting the most appropriate scanning techniques for the intended applications. For this purpose, a 25 mm thick welder qualification test plate with natural defects (verified by RT) was studied.
Percepção do Adolescente frente à sua Condição de Adoecimento Oncológico
Authors: Costa Vânia Chagas da , Melo Nathália Rodrigues Martins de , Nascimento Monique Maria de Lima , Leão Deuzany Bezerra de Melo , Nascimento Carlos Alberto Domingues do , Bushatsky Magaly
Published: December 2021

Introdução: O adoecimento por câncer traz uma rotina cansativa por conta das terapêuticas agressivas, e ocorrem mudanças na vida do adolescente. Objetivo: Compreender a percepção do adolescente frente a sua condição de adoecimento oncológico. Método: Pesquisa exploratória, descritiva, qualitativa, por meio da técnica do discurso do sujeito coletivo, realizada com 13 adolescentes, no período de junho a agosto de 2019, no Centro Especializado em Oncologia Pediátrica de um hospital universitário. As entrevistas individuais foram gravadas baseadas nos seguintes questionamentos: Para você, como e estar doente? O que você pensa sobre seu futuro? Como você se relaciona com seus familiares e com a equipe de saúde? Resultados: Foram identificadas oito ideias centrais, entre elas: estar doente e ruim porque limita rotinas da vida normal; o tratamento e doloroso e altera minha imagem corporal; estar doente tem um lado bom; ficar curado e retomar planos para minha vida; o hospital e a equipe de saúde são acolhedores; falta empatia e acolhimento adequado; humanização na assistência; e apoio familiar. Conclusão: Na percepção do adolescente, o adoecimento vai além da condição de saúde física, interfere e limita sua qualidade de vida e dos familiares, e a escuta terapêutica é essencial para uma assistência humanizada.
Identification of suspected paleotsunami deposits study from Karapyak Beach, Pangandaran area, West Jawa, Indonesia
Authors: Aswan Aswan , Rizal Yan
Published: December 2021

Identifying and constraining palaeotsunami deposits can be a vital tool for establishing the periodicity of earthquakes and their associated tsunami events beyond the historical records. However, the deposits can be difficult to establish and date. In this study we used the characteristics of the 2006 Pangandaran tsunami deposit as a reference for identification of paleotsunami deposits in Karapyak Beach, Pangandaran area, West Java, Indonesia. Similar to the 2006 Pangandaran tsunami deposit, the Karapyak Beach paleotsunami deposit is characterized by light brown loose sand materials overlying a dark brown paleosoil layer with erosional contact. A thin layer that varies in thickness is locally found right above the erosional contact, with non-laminated coarser grain in the lower part that gradually change into medium to fine sand-sized in upper part. The base of the lower part is rich with broken mollusc shells and corals, and the mid-top of the lower part may contain several intact molusc shells and corals, rock fragments and anthropogenic products (rooftile). Those types of fragments are absent in the upper part of the thin layer. Grain size analysis shows a mixture of fine and coarse grains in the lower part of 2006 tsunami deposits as well as in the suspected paleotsunami deposits, suggesting uprush high energy flow during sedimentation. Fining upward sequence above mixed grain layers reflects waning flow or pre-backwash deposition. Foraminifera analysis also shows a mixture of shallow and deep marine foraminifera in the two deposits. Based on the characteristics of the 2006 tsunami deposits, there are at least four identified paleotsunami deposits at Karapyak Beach, Pangandaran area.
The Ideological Legacy of Charles de Gaulle. II. National Paradigm. Part 2. A Concept of France's Greatness
Authors: NAROCHNITSKAYA Ekaterina
Published: December 2021

The imperative of France's grandeur was one of de Gaulle’s national idea essential elements which is as widely known as it is often misinterpreted. Although such classical vocabulary was disappearing from European political discourse, the founder of Gaullism used the notion of greatness strongly rooted in French political culture as a mobilizing symbolic force for meeting crucial domestic challenges. The motive of greatness was also closely linked with the principles of France’s autonomy and global responsibility, on which de Gaulle pivoted the positioning of the Fifth Republic in the post-war world.
All this conflicted with the supranational Euro-Atlantic project, which was the main reason for the sharp negativism against de Gaulle's strategy and rhetoric, accused of "archaic thinking" by his opponents. In fact, the "last great Frenchman’s” concept of "greatness" was quite unorthodox in its reasoning and content, which are of particular interest as part of his relevant ideological legacy. Instead of axiomatic superiority, restoration of former power, civilizing mission, he insisted on the importance of high goal setting, vast undertakings and historical actorness, which were in de Gaulle’s view the existential imperative of French history.
THERMODYNAMIC PROPERTIES OF THE Sb2Te3 COMPOUND
Authors:   Azerbaijan State Oil and Industry University, Aliyev F.R. , Orujlu E.N. ,   M.Nagiyev Institute of Catalysis and Inorganic Chemistry, of NAS of Azerbaijan, Babanly D.M. ,   French–Azerbaijani University, UFAZ
Published: December 2021

Thermodynamic properties of the Sb2Te3 compound were studied by measuring electromotive force (EMF) with a liquid electrolyte in the temperature range of 300-450 K. The partial molar functions of antimony in alloys and the corresponding standard integral thermodynamic functions of the Sb2Te3 compound were calculated for the first time based on the EMF measurements under standard conditions. Comparative analysis of obtained results with literature data was carried out
The Effectiveness of Job Rotation in Enhancing Knowledge Accumulation - A Field Study of the Opinions of a Sample of Employees at Al-Kitab University
Authors: Ahmed Ahmed Farhan
Published: December 2021

The study aims to examine the effectiveness of job rotation in enhancing the knowledge accumulation of workers' opinions at the Iraqi Al-Kitab University by measuring the impact and testing the relationship between job rotation and knowledge accumulation. 62 valid questionnaires were distributed. The study used the statistical program (SPSS) to prove the validity of the research hypotheses related to the correlation and influence between the two research variables (functional rotation, knowledge accumulation). The findings revealed a positive moral correlation between the combined job rotation and the combined knowledge accumulation of the university under study in terms of its variables according to the value of the correlation coefficient at the aggregate level. Some recommendations related to the results of the research were made, the most important of which were: the necessity of developing and pumping new blood into the university, helping the employee and the university to get out of the cycle of stagnation, and resisting the change caused by the belief that the job is the property of the employee.
Diversity of Learners: A Study about how Individual Differences Affect the L2 Learning Process
Authors: Valle John Ramil A. , Ilustre Ramil G. , Figuracion Donna May R. , Cabahug Larme M. , Paningbatan Rosario R. , Guerrero Karlyn Cherlot C. , Amparo Maria Joanna E.
Published: December 2021

Individual differences are considered one of the main factors in language learning. This article begins by presenting the definition of individual differences and identifying the possible individual differences that may affect the L2 learning process are. Based on the literature review, shows that there are eight (8) major individual differences to be found as salient features in the L2 learning process. A brief overview of these eight (8) individual differences is provided, supported by the literature review of 20 journal articles. This journal article used grounded theory design as a method in identifying the relationship of the following individual differences in the L2 learning process. According to the results, although there is a growth in the study of individual differences that affects the L2 learning process, there is still much work to be done and much more investigation is required.
Cash Waqf Linked Sukuk (CWLS) di tengah Pandemi Covid-19 dan Implementasinya Terhadap Ketahanan Ekonomi
Authors: Danugroho Agus , Sa’adah Aqidah Halimatus
Published: December 2021

This study aims to determine how the Cash Waqf Linked Sukuk or CWLS program is in the midst of the Covid-19 pandemic and its implications for economic resilience. The system pioneered and implemented by the Indonesian Waqf Board or BWI is an interesting matter to study. In addition, based on the analysis of the CWLS research VOSViewer software, not many have researched it. Researchers use policy making theory which is used as a research point of view. This research is a descriptive qualitative research. The results of this study indicate that the CWLS waqf system is a form of social investment in Indonesia. The Indonesian Waqf Board acts as an accelerator. The subject of this system is the cash waqf itself collected by BWI as the manager of Indonesian waqf or Nazhir through BNI Syariah and Bank Muamalat Indonesia as Islamic Financial Institutions Receiving Cash Waqf or LKSPWU. Then the cash waqf will later be managed and placed in the State Sukuk Instrument or State Sharia Securities (SBSN) issued by the Ministry of Finance (Kemenkeu). CWLS itself also implements economic resilience. It can be seen on the BWI website on Cash Waqf Linked Sukuk (CWLS) that the government will use the results of the issuance of this State Sukuk to finance the state budget, including to finance the development of public service projects such as the development of educational infrastructure and religious services
More than just a regime type: how Southeast Asian countries respond to COVID-19
Authors: Iberahim Muhammad Maulana
Published: December 2021

As early as the pandemic has spread to Southeast Asian countries and elsewhere, observers have been tempted to associate regime type with COVID-19 responses. This trend encompasses the debate between democratic vs. authoritarian regimes that has been particularly helpful in identifying the normative basis to global pandemic responses. However, it leads into an inquiry whether the comparison of regime as part of variable isolation is scientifically viable in assessing the public policy, given the fact that the comparative matrix is vague. The comparison between democracy and the authoritarian regime will not bring a fair debate, but only to insinuate epistemological obstacle due to socially constructed dichotomy between the two even if the authoritarian regime has done any good practice. Furthermore, such a dichotomy only reflects a binary oversimplification of reality, which neglects an alternative explanation. Drawing on the framework of typology of COVID-19 responses by Greer et. al. (2020)–which includes four key foci, i.e., social policies and crisis management, regime type, formal political institutions, state capacity–this article will extend the framework by applying to the case of Southeast Asian countries, where these countries share similar structure and challenges, yet some countries arguably have been more successful.
Parameterized families of polylog integrals
Authors: Sofo Anthony , Batir Necdet
Published: December 2021

It is commonly known that integrals containing log-polylog integrands admit representations in terms
of special functions such as the Dirichlet eta and Dirichlet beta functions. We investigate two parameterized families
of such integrals and in a particular case demonstrate a connection with the Herglotz function. In the process of the
investigation we recover some known Euler sum equalities and discover some new identities.
Efecto de fisuras en la tracción de juntas soldadas de acero A36 mediante simulación numérica
Authors: Serrano Aguiar Carlos Oswaldo , Calispa Aguilar Marcelo Esteban , Ordoñez Viñan Marco Antonio , Choto Chariguamán Luis Santiago
Published: December 2021

Introducción. Las fisuras son las discontinuidades más críticas que se presentan en la soldadura, desplegando una alta concentración de esfuerzos y por ende una reducción de las cargas que se pueden aplicar a las juntas soldadas, normas de construcción de sistemas de transportación de oleoductos como la API 1104, es muy estricta respecto a la aceptación de estas discontinuidades, pero con una fundamentación empírica. Objetivo. Determinar la influencia que tiene la longitud de las fisuras en el esfuerzo de fluencia de juntas soldadas con el acero ASTM A36 mediante simulación numérica por elementos finitos. Metodología.  Se realiza un análisis cualitativo de determinación de la carga que se puede aplicar a tuberías unidas mediante soldadura con fisuras, las variables independientes son el espesor de tubería, la longitud de la fisura y el diámetro de tubería. Se selecciona tuberías comerciales desde 4 hasta 20 in de diámetro nominal, con 3 espesores cedula 40, XS y 80, además se introduce dos fisuras en la superficie de la junta soldada de 2 y 4 mm de longitud, el modelo geométrico se realizó en el software Solidworks y el análisis estático con elementos finitos en ANSYS, los resultados fueron analizados en SPSS mediante el método de regresión lineal múltiple. Resultados. La variable independiente con mayor influencia en la dependiente es el diámetro de la tubería, seguida de la longitud de la fisura y finalmente el espesor de las tuberías, esto medida por la correlación entre las variables y el modelo a pasos de la regresión. Conclusión. Todas las variables tienen un comportamiento lineal y directamente proporcional a la fuerza permitida aplicable a la junta soldada
ENVIRONMENTAL MONITORING USING ADOLESCENTS’ SALIVA IN OMSK
Authors: Sarf E. A. , Dergacheva M. V. , Zharkikh L. A. , Bel'skaya L. V.
Published: December 2021

Introduction: An effective way to improve the quality of public health is to search for early, pre-pathological changes in the body under the influence of many technogenic factors, which will make it possible to make predictions of the pre-nosological state for the future. Aim: To assess the impact of the environment on the biochemical parameters of saliva in adolescents living in areas with different levels of environmental stress. Methods: The study involved 90 adolescents aged 14 to 16 years (39 boys, 51 girls), living in six administrative districts of Omsk with different levels of environmental pollution. Saliva samples were collected in the morning on an empty stomach, and the biochemical composition was determined using 22 parameters. Intergroup differences were assessed by a nonparametric criterion and principal component analysis (PCA). Results: None of the parameters measured in saliva can be used to characterize the area of residence. PCA showed that that the maximum contribution was made by electrolyte components, protein, and triene conjugates (TC). At the same time, the regions with the maximum differences in the studied biochemical parameters of saliva are geographically distant from each other. So, in ecologically unfavorable areas in saliva the TC level is the highest 0.954 (0.677; 1.019) c. u. and the chloride content is the lowest 8.4 (5.9; 10.6) mmol/L. The opposite trend is observed for ecologically safe areas: the TC level decreases 0.864 (0.792; 1.018) c. u., the chloride content increases 16.1 (9.7; 18.6) mmol/L. A combination of indicators of saliva was revealed, which allows characterizing the state of the body in an integral form. Conclusions: The use of PCA of biochemical parameters of saliva allows monitoring of the ecological situation in the areas of residence supporting the evidence from environmental monitoring in the study area.
NEUROVEGETATIVE SYSTEM CONDITIONS DURING WINTER MARATHON IN MEN
Authors: Eskov V. M. , Pyatin V. F. , Galkin V. A. , Chempalova L. S.
Published: December 2021

Introduction: Long-duration physical activity in winter is associated with significant demands for neurovegetative system. Aim: To explore the changes in the parameters of sympathetic and parasympathetic neurovegetative systems in men during a winter marathon. Methods: Parameters of the sympathetic and parasympathetic nervous systems of the group were estimated in 15 men after the winter marathon (50 km) using an automated computer-based system. Pairwise comparisons matrices of the parameter of the sympathetic and parasympathetic systems before and after the marathon were performed. There were found the k numbers of pair samples that had a common general population. Results: Four matrices of pairwise comparisons were constructed and shown the increasing of the proportion of stochastic from k1 = 11 to k2= 13 for the sympathetic autonomic nervous system. Conclusions: An equidirectional dynamic of stochastic's proportion changes before and after the marathon is observed. For the sympathetic and parasympathetic systems, the drop of chaos is observed, but we still can make a conclusion on the statistical instability of the samples.
Early myocardial functional abnormalities in primary dyslipidemia: clinical and echocardiographic observations in young children from a highly consanguineous population
Authors: El-koofy Nehal M. , Fattouh Aya M. , Ramadan Areef , Elmonem Mohamed A. , Hamed Dina H.
Published: December 2021

Background: Dyslipidemia is a major health problem among children and adolescents worldwide due to its significant association with cardiovascular disease. Primary dyslipidemias are commonly familial syndromes that can be completely asymptomatic.Purpose: Apart from the risk of coronary artery disease (CAD), limited data are currently available on the direct effects of dyslipidemia on myocardial function in children.Methods: We recruited 25 children with primary dyslipidemia (14 with isolated hypercholesterolemia, 4 with isolated hypertriglyceridemia, and 7 with combined dyslipidemia). Relevant clinical manifestations and laboratory and radiological investigations were evaluated. Pulsed-wave Doppler and tissue Doppler imaging echocardiography were performed for all recruited patients and the results were compared with those of 15 age- and sex-matched healthy children.Results: The median age of the dyslipidemic children was 8 years (range, 1.5–16 years). A family history was documented in 13 cases (52%), while 18 (72%) had consanguineous parents. None of the dyslipidemic children had a personal history or clinical manifestations of CAD. In contrast, echocardiographic findings differed in several diastolic function parameters of both right and left ventricles in dyslipidemic children compared to controls. Based on normalized z scores, aortic valve narrowing was detected in 7 patients (28%), while narrowing of the aortic sinus (sinus of Valsalva) was detected in 15 patients (60%).Conclusion: Different types of primary dyslipidemia produce functional myocardial abnormalities early in childhood. Biochemical and echocardiographic screening of high-risk children is advised to minimize the incidence of serious cardiovascular complications.
Протидія кримінальним правопорушенням, учиненим у кіберпросторі, як новий напрям криміналістики
Authors: САМОЙЛЕНКО ОЛЕНА
Published: December 2021

Діяльність із розслідування кримінальних правопорушень потребує реалізації широкого кола завдань правоохоронних органів, серед яких одним з основ них завдань визнається протидія кримінальним правопорушенням. Сьогодні середовищем вчинення більшості останніх є кіберпростір. Телекомунікаційна мережа, комп’ютерна інформація та інші елементи такого середовища будуть предметом, знаряддям та/або засобом широкого кола злочинних посягань – від сфери національної безпеки до відносин власності. Десятиліттями в криміналістиці приділялася увага проблемам розслідування лише тих діянь, які докладно описані як кіберзлочини в Конвенції про кіберзлочинність, що, звісно, не відповідало умовам часу.
Метою статті є дослідження протидії кримінальним правопорушенням, учиненим у кіберпросторі, як нового напряму криміналістичної науки.
У статті визначені й описані складнощі, що виникають на шляху успішності теоретичних розробок, і перспективи дослідження окремих структурних одиниць визначеного наукового напряму.
Встановлено, що структурно науковий пошук учених у цьому напрямі можна активізувати для вирішення двох груп завдань: 1) формування концептуальних засад протидії таким правопорушенням; 2) визначення структурних одиниць вказаного напряму, зокрема напрямів формування методик розслідування кримінальних правопорушень, учинених у кіберпросторі; відповідно, розроблення останніх.
У результаті аналізу криміналістичної діяльності з протидії злочинності та на підставі наявних розробок у галузі філософії, кібернетики та телекомунікаційних технологій конкретизовані вихідні загальнотеоретичні положення у досліджуваному науковому напрямі криміналістики. По-перше, виокремлено два рівня злочинної діяльності у кіберпросторі, зокрема: 1) сукупність одиничних злочинів, що мають взаємозв’язок за розвитком; 2) злочинні технології. По-друге, криміналістичну класифікацію цієї множини правопорушень визнано підґрунтям розроблення комплексної методики (теоретико-методичних засад) розслідування кримінальних правопорушень, учинених у кіберпросторі. По-третє, обґрунтовано, що полімотивованість злочинної діяльності у кіберпросторі є принциповим підходом при розв’язанні питань оптимізації протидії відповідній категорії правопорушень. По-четверте, спільний аналітичний підхід до процесу протидії кібрзлочинам уповноважених на це суб’єктів і ситуаційну обумовленість визнано ключовими аспектами побудови та реалізації тактичних операцій при розслідуванні кримінальних правопорушень, учинених у кіберпросторі.
Ischemic Tolerance – Blessing or Curse
Authors: BURDA J , BURDA R
Published: December 2021

Application of knowledge about ischemic tolerance to clinic requires the solid understanding of mechanism of creation of this phenomenon. This review summarizes research that has been carried out in many laboratories over a long period of time, but the main focus will be on own experimental research. The main emphasis is devoted to the possibility of preparing full tolerance in the donor's body and its transfer to the patient in the form of activated blood plasma. Such plasma could be administered as soon as the patient is transported to the hospital and would take effect immediately after administration to the patient's bloodstream. One chapter is also devoted to anticonditioning, i.e. the possibility of preventing the activation of tolerance. Anticonditioning could be used to treat oncologic patients. We expect that this method could increase effectiveness of cancer treatment. Cross-tolerance with a wide range of diverse stressors gives us the courage to assume that activated plasma can significantly help with a wide range of pathological events.
The Cell Body Space Occupied by the Nucleus During the Cell Differentiation in Human Lymphocytic, Granulocytic and Erythroid Cell Lineages
Authors: SMETANA K , KLAMOVÁ H , MIKULENKOVÁ D , ČERMÁK J , OTEVŘELOVÁ P , KARBAN J , TRNĚNÝ M
Published: December 2021

The present nuclear and cell body diameter measurements demonstrated size differences of the approximate cell space estimate occupied by the cell nucleus during the cell differentiation in lymphocytic, granulocytic and erythroid cell lineages. These lineages were used as convenient models because all differentiation steps were easily identified and accessible in diagnostic peripheral blood or bone marrow smears of blood donors (BDs), patients suffering from chronic lymphocytic leukemia (CLL), patients with chronic myeloid leukemia (CML) and refractory anemia (RA) of the myelodysplastic syndrome (MDS). The cell space occupied by the nucleus was constant and did not change during the cell differentiation in the lymphocytic cell lineages of BDs and CLL patients despite the decreased cell size. In contrary, the cell space occupied by the nucleus markedly decreased in differentiating cells of granulocytic and erythroid lineages of patients suffering from CML. In the erythroid cell lineage in patients with RA of MDS the small reduction of the cell space occupied by the nucleus during the differentiation was not significant. The measurements also indicated that in progenitor cells of all studied cell lineages nuclei occupied more than 70 % of the cell space. Thus, the nucleus-cytoplasmic morphological and functional equilibrium appeared to be characteristic for each differentiation step and each specific cell lineage.
Changes in Phenotypic Patterns of Blood Monocytes After Kidney Transplantation and During Acute Rejection
Authors: ŠVACHOVÁ V , KRUPIČKOVÁ L , NOVOTNÝ M , FIALOVÁ M , MEZEROVÁ K , ČEČRDLOVA E , LÁNSKÁ V , SLAVČEV A , VIKLICKÝ O , STŘÍŽ I
Published: December 2021

Peripheral blood monocytes, which serve as precursors for tissue macrophages and dendritic cells (DC), play a key role in the immune response to kidney allograft, reparation processes and homeostasis regulation. In this prospective study, we used multicolor flow cytometry to monitor the phenotypic patterns of peripheral monocytes in subjects with uncomplicated outcomes and those with acute rejection. We found a reciprocal increase in the proportion of “classical monocytes” (CD14+CD16-) along with a decline in pro-inflammatory “intermediary” (CD14+CD16+) and “non-classical” (CD14lowCD16+) monocytes in subjects with normal outcomes. In subjects with acute rejection, we observed no reduction in “intermediary” monocytes and no increase in “classical” monocytes. Patients with uncomplicated outcomes exhibited downregulated HLA-DR in all three monocyte subpopulations. However, non-classical monocytes were unaffected in subjects with acute rejection. Expression of CD47 was downregulated after transplantation, while patients with antibody-mediated rejection and donor-specific antibodies showed higher pre-transplant values. In monocytes isolated at the time of biopsy, CD47 expression was higher in individuals with acute rejection compared to patients with normal outcomes one year post-transplant. Expression of CD209 (DC-SIGN) and the proportion of CD163+CD206+ subpopulations were upregulated during the first week after kidney transplantation. CD209 was also upregulated in samples taken on the day of biopsy confirming acute rejection. Our data demonstrate that kidney allograft transplantation is associated with phenotypic changes in peripheral blood monocytes during acute rejection.
Pregnancy-Related Thromboembolismin Sickle Cell Disease
Authors: AlDallal Salma M.
Published: December 2021

Haematological disorders are predominant in the tropical and subtropical countries where major problems of sickle-cell disease (SCD) and thalassaemias are often recorded. However, reports of these conditions have increased in the Western hemisphere more recently. Genetic counselling, early detection of the disease condition, and determining an appropriate treatment regimen remains the solution. Most molecular types of SCD have been determined and the pathological impact of individual types along with the degree of severity is known to clinical investigators and physicians. There is, however, a significant need for a proper counselling system for the clinical diagnosis in most countries. Lack of funding, trained personnel, relevant physicians, instruments, and laboratories are the challenges to overcome. Pregnancy-associated SCD and thromboembolism require special mention due to their mortality rate, complexity of treatment, and care necessities. This review considers some of the most important aspects of pregnancy-associated SCD and thromboembolism, shedding light on the present understanding of the disease condition, pathology, clinical issues, the association with venous thromboembolism, recent treatment measures, and clinical and social management of pregnant women and fetuses for patients with SCD. Integrated social and clinical care along with extensive timely medical and clinical counselling for patients can improve the present situation which is growing in different countries. To save future generations and pregnant mothers from the haematological disorders that could be either prevented or treated, essential genetic screening or counselling should be made a priority by governments. In addition, social education and campaigns related to the disease condition can help to improve the situation.
Adult-Onset Still’s Disease Complicated with Haemophagocytic Lymphohistiocytosis (HLH): A Case Report
Authors: Asghar Muhammad Sohaib , Tauseef Abubakar , Fatmi Warda , Khan Narmin , Zafar Maryam , Rasheed Uzma , Shaikh Nimra , Akram Mohammed , Fayaz Basmah , Iqbal Zehra
Published: December 2021

Haemophagocytic lymphohistiocytosis (HLH) is a rare but potentially aggressive and life-threatening syndrome of overactive histiocytes and lymphocytes that commonly affects infants; it is also observed in children and adults of all ages. The disease is differentiated into either primary or secondary causes. Primary HLH tends to be of genetic origin, while secondary HLH results from either infection, autoimmune disorders, or malignancies. Secondary HLH is most commonly associated with viral infections in immunocompromised patients. This paper presents a case of HLH in a tertiary care hospital, associated with adult-onset Still’s disease, diagnosed on both biochemical criteria and histopathologic examination of bone marrow smear.
Cholangioscopy and its Primary Sclerosing Cholangitis
Authors: Fung Brian , Fejleh Phillip , Tejaswi Sooraj , Tabibian James
Published: December 2021

Primary sclerosing cholangitis (PSC) is a cholestatic liver disease characterised by chronic inflammation and fibro-obliteration of the intrahepatic and/or extrahepatic bile ducts. It is associated with numerous hepatobiliary complications including an increased risk of malignancy (in particular, cholangiocarcinoma) and biliary tract stone formation. The evaluation of biliary strictures in patients with PSC is especially challenging, with imaging and endoscopic methods having only modest sensitivity for the diagnosis of cholangiocarcinoma, and treatment of biliary strictures poses a similarly significant clinical challenge. In recent years, peroral cholangioscopy has evolved technologically and increased in popularity as an endoscopic tool that can provide direct intraductal visualisation and facilitate therapeutic manipulation of the biliary tract. However, the indications for and effectiveness of its use in patients with PSC remain uncertain, with only a few studies performed on this small but important subset of patients. In this review, the authors discuss the available data regarding the use of peroral cholangioscopy in patients with PSC, with a focus on its use in the evaluation and management of biliary strictures and stones.
Gastrointestinal Inflammation and the Gut Microbiome: An Evolving Conceptual Framework with Implications for Diagnosis and Therapy in Inflammatory Bowel Disorders
Authors: Grundmann Oliver
Published: December 2021

The human gut microbiome has garnered much attention over the past two decades with important discoveries linking it to human health and disease. The commensal bacterial flora evolves due to the influence of a number of factors including diet, pathogen exposure, environmental toxicants, disease states, and a challenged microenvironment that requires balancing with the host itself. However, the composition of bacterial species can impact and contribute to the development of local and systemic inflammation. Among the factors attributed to intestinal inflammation are dysbiosis caused by pathogenic bacteria, following decreased host immunity or loss of intestinal barrier function. Dysbiosis can also be triggered by antibiotic therapy or the use of other medications that allow for colonisation of pathogenic bacteria, such as proton pump inhibitors. The imbalance with commensal bacteria leads to the generation of proinflammatory mediators and a reduction of host immune defences, due to a lack of short-chain fatty acid generation needed for energy production to maintain barrier and immune function. The initially localised inflammation results in further dysbiosis as former commensal bacteria are able to breach the barrier and cause systemic immune responses. Low-grade systemic inflammation is a hallmark of inflammatory bowel disease. Because a specific dysbiosis is common in patients with inflammatory bowel disease, it can serve as an early diagnostic marker in its development. Furthermore, faecal microbiome transplants have shown promising benefits in patients with ulcerative colitis and Crohn’s disease.
D-chiro-inositol, Vitamin D, and Epigallocatechin Gallate Avoid Surgery in Females with Uterine Fibroids: Two Case Reports
Authors: Oliva Mario Montanino
Published: December 2021

Uterine fibroids (UF) represent the most common benign tumours in females of reproductive age, and can negatively affect fertility. Patients with UFs need to reduce the tumour size with pharmacological treatments or surgically remove the fibroid before using assisted reproductive technology (ART). On the other hand, surgery implies long waiting times before ART to avoid the risk of rupture of the uterus. Long waiting periods are often unacceptable for older individuals who want to undergo ART procedures. Unfortunately, no specific and safe treatment for UFs is currently available. Here the author reports two cases of patients with UFs and associated heavy menstrual bleeding who seek pregnancy through ART. Both underwent a daily treatment with epigallocatechin gallate, vitamin D, vitamin B6, and D-chiro-inositol for 3 months. The patients showed a volume reduction of 73.8% and 68.4%, respectively. This was associated with decreased blood loss (42.1% and 48.7%, respectively). After 3 months from the end of the treatment, both patients underwent ART procedure without the need for surgical intervention.
A File Encoding Using A Combination of Advanced Encryption Standard, Cipher Block Chaining and Stream Cipher In Telkom Region 4 Semarang
Authors: Handoko Lekso Budi , Krismawan Andi Danang
Published: December 2021

The increase in significant advances in information technology greatly provides comfort and convenience in managing data. This convenience is what makes people who are not responsible for using it as a crime such as hacking, cracking, phishing, and so on. In Telkom Region 4 Semarang, there is a container where there are important company data such as customer data. Customer data is very important and the contents of the data must be kept confidential. The company has experienced significant losses due to information leakage due to negligence in the last 5 years. For this reason, data security is necessary so that data is safe and is not misused. This study applies the Advance Encryption Standard algorithm - Cipher Block Chaining (AES-CBC) and Stream cipher in order to secure data so as to reduce the risk of data theft by telecom subscribers. Based on the average avalanche effect value of AES-CBC and a stream cipher of 49.34%, this shows that the AES-CBC and Stream Cipher encrypted files are difficult to crack so that data confidentiality is well maintained.
Designing The Concepts - Framework & The Maturity Level Of Smart Pondok Pesantren (Islamic Boarding Schools)
Authors: Novianto Sendi , Gamayanto Indra , Alzami Farrikh
Published: December 2021

Abstract - The development of information technology and significant progress is happening today, where changes need to face increasingly high global competition. Islamic boarding schools are the centre of change, where boarding schools must develop four important factors: human resource development, information technology, culture and e-spirituality. This article is about developing smart city 3.0 and 5.0, where the resulting framework and methods can apply to Islamic boarding schools. Our research object is Islamic boarding schools, and in this place, we do community service. This article's results are the framework and the maturity level of smart Islamic boarding schools, where there are three indicators (people-culture, technology-business, implementation-global goals)  and three important levels (stage 1-the foundation, stage 2-good foundation, stage 3- great foundation), which are the basis for developing a smart islamic boarding school. Moreover, this article is version 1.0, which in its development will extend to the application. An application Si-PenO (Online registration information system) completed at the Askhabul Kahfi Islamic boarding school as proof of applying the concept we created in this article. This change is needed to face globalization, and change is a good thing if it does systematically. Furthermore, this article will continue to develop in versions 2.0 and 3.0 and applications that we will implement in Islamic boarding schools.
A Video Quality Testing : Review of Human Visual Aspect
Authors: Krismawan Andi Danang , Handoko Lekso Budi
Published: December 2021

Various types of video player applications have been widely used by the community. The emergence of the latest version and a variety of features make people need to make a choice to use a video player application with a good visual level. The type of video that is often played is a file with an MP4 extension. This file type is not heavy but is usually intended for long file durations such as movies. In this paper, we will use a dataset in the form of a movie file with an MP4 extension. The video player applications used include VLC, Quick time, Potplayer, KMPLayer, Media Player Classic (MPC), DivX Player, ACG Player, Kodi, MediaMonkey. Through various empirical calculations, such as Mean Square Error (MSE), Peak Signal to Noise Ratio (PSNR), Structutral Similarity Index Measurement (SSIM), Threshold F-ratio, Visual Signal to Noise Ratio (VSNR), Visual Quality Metric (VQM), and Multiscale - Structutral Similarity Index Measurement (MS-SSIM) has analyzed the visual capabilities of each video player application. Experimental results prove that the KMPlayer application gets the best visual results compared to other selected applications.
Improvement of Accuracy and Handling of Missing Value Data in the Naive Bayes Kernel Algorithm
Authors: Bijanto Bijanto , Yunus Ryan
Published: December 2021

The lost impact on the research process, can be serious in classifying results leading to biased parameter estimates, statistical information, decreased quality, increased standard error, and weak generalization of the findings. In this paper, we discuss the problems that exist in one of the algorithms, namely the Naive Bayes Kernel algorithm. The Naive Bayes kernel algorithm has the disadvantage of not being able to process data with the mission value. Therefore, in order to process missing value data, there is one method that we propose to overcome, namely using the mean imputation method. The data we use is public data from UCI, namely the HCV (Hepatisis C Virus) dataset. The input method used to correct the missing data so that it can be filled with the average value of the existing data. Before the imputation process means, the dataset uses yahoo bootstrap first. The data that has been corrected using the mean imputation method has just been processed using the Naive Bayes Kernel Algorithm. From the results of the research tests that have been carried out, it can be obtained an accuracy value of 96.05% and the speed of the data computing process with 1 second.
E-Report System to Help Monitor Student Academic Progress Using Forward Chaining for Grade Promotion According to Student Development Level
Authors: Mulyono Ibnu Utomo Wahyu , Ningrum Novita Kurnia , Umami Zahrotul , Widyatmoko Karis
Published: December 2021

The COVID-19 pandemic that has occurred in the world and Indonesia is one of the affected countries. To limit the rate of transmission of COVID-19, the Ministry of Education issued regulations relating to online schools. With this online school, both parents and teachers need media to be able to monitor students' academic progress as long as online schools are implemented. Therefore, we need a system that can assist teachers and parents in monitoring students' academic progress. In this study, an e-report was designed by incorporating the components of students' academic aspect and students' character aspect. This system is supported by a decision support system using forward chaining to determine the feasibility of a grade increase according to the level of development of the student. The output of this system is student grade reports, advice given to parents and grade promotion decisions based on academic and character aspect.
HEALTH SERVICES VOCATIONAL SCHOOL STUDENTS’ KNOWLEDGE LEVELS OF ON PARASITIC DISEASES
Authors: EKİCİ Abdurrahman , YÜREKTÜRK Şehriban , ELASAN Sadi , HALİDİ Ahmed Galip , KARAKUŞ Sinan , AYDEMİR Selahattin , ŞAHİN Maksut , YASUL Muhammed , YİLMAZ Hasan
Published: December 2021

In this study, it has been aimed to determine the knowledge level of the students of Van Yuzuncu Yıl University Health Services Vocational School, who will serve as the health personnel of the future, about parasitic diseases, prevention and control measures from these diseases. A total of 587 students, comprising 418 (71.2%) females and 169 (28.8%) males, studying at Van Yüzüncü Yıl University Health Services Vocational School, were included in the study. The questions in the questionnaire were arranged in three groups, as those about parasitic diseases, transmission routes of these diseases, and prevention and treatment. Cronbach alpha coefficients were calculated within the scope of the reliability analysis of the questionnaire questions. The Cronbach alpha values for the domains of Knowledge Level About Parasitic Diseases, Knowledge Level About the Transmission of Parasitic Diseases, and Knowledge Level About the Prevention and Treatment of Parasitic Diseases were determined as 0.647 (64.7%), 0.707 (70.7%), and 0.566 (56.6%), respectively. A statistically significant difference was found between the departments included in the study in terms of the level of knowledge about parasitic diseases (P < 0.05). A statistically significant difference was found between the departments in the evaluation made between the level of knowledge about the prevention and treatment of parasitic diseases and the personal characteristics of the students (P < 0.05). As the result, it was observed that the students participating in the study did not have sufficient knowledge about parasitic diseases.
Analisis Tingkat Kerawanan Banjir di Kabupaten Semarang Menggunakan Overlay dan Skoring Memanfaatkan SIG
Authors: Ramadhan Dawa Rysqyqa , Chernovita Hanna Prillysca
Published: December 2021

Abstrak: Bencana banjir merupakan bencana yang sering terjadi di wilayah iklim tropis khususnya daerah yang letaknya dikelilingi oleh aliran air atau genangan air seperti danau. Banjir di Indonesia dipengaruhi oleh pergantian musim yang tidak menentu yang menyebabkan bencana banjir. Penelitian ini bertujuan untuk memetakan wilayah yang rawan terhadap banjir dan mengetahui sebarapa besar tingkat kerawananan banjir yang dapat terjadi di studi area penelitian pada wilayah Kabupaten Semarang. Penelitian ini menggunakan metode overlay dengan tumpang susun layer, berdasarkan hasil perhitungan total scoring dari nilai dan bobot dari tiap parameter. Pengumpulan data dilakukan dengan mengumpulkan data sekunder berupa data spasial dan non spasial dari lembaga resmi Negara Indonesia, yang dipakai untuk mendukung analisis yang dilakukan. Dari hasil analisis yang dilakukan pada studi area penelitian di wilayah Kabupaten Semarang, diketahui terdapat 159 desa pada daerah dengan tingkat kerawanan yang rendah, serta 109 desa pada daerah dengan tingkat kerawanan sedang, sisanya 20 desa berada pada tingkat kerawanan tinggi. Dari analisis yang dilakukan, dapat ditarik kesimpulan bahwa wilayah Kabupaten Semarang khususnya pada daerah studi area penelitian menghasilkan informasi dari empat kecamatan yang ada, memiliki tingkat kerentanan yang didominasi oleh tingkat tidak rawan dan cukup rawan. Kata kunci: Bencana Banjir, Overlay, Scoring, Sistem Informasi Geografi.Abstract: Disaster flood disasters that occur in climatic areas, especially areas associated with water flows or puddles such as lakes. Floods in Indonesia are inspired by the changing seasons that are disastrous floods. This study aims to map the areas that are prone to flooding and how much danger is the level of flood vulnerability that can occur in the study area of Semarang Regency. This study uses an overlay method with overlapping layers, based on the calculation of the total score of the values and weights of each parameter. Data collection was carried out by collecting secondary data in the form of spatial data and non-official Indonesian institutions, which were used to support the analysis carried out. From the results of the analysis carried out in the study area of research in Semarang Regency, it is known that there are 159 villages in areas with low levels of vulnerability, as well as 109 villages in areas with moderate levels of vulnerability, the remaining 20 villages are at high levels of vulnerability. From the analysis carried out, it can be concluded that the Semarang Regency area, especially in the study area the research area produces information from the four existing sub-districts, has a level of vulnerability which is dominated by a level of vulnerability which is not vulnerable and quite vulnerable. Keywords: Flood Disaster, Overlay, Scoring, Geographic Information System.