bluuebunny/crossref_metadata_2025 huggingface dataset:
Efeito do isolamento decorrente da Covid-19 sobre os casos de sífilis e AIDS no Município de Fernandópolis, Estado de São Paulo, Brasil
Authors: Amêndola Olivia Mendes , Rocha Artur Otoni Lima , Kol Luana Teixeira , Speretta Emille , Oliveira Yasmim Janiele Campos de , Pedroso Rafaela Pelluco , Kozusny-Andreani Dora Inês
Published: September 2024

No início de 2020, o mundo foi atingido pela COVID-19, uma doença provocada pelo SARS-CoV-2. Para conter a disseminação do vírus, o Brasil adotou medidas de isolamento social devido à alta transmissibilidade e letalidade da doença. Objetivou-se neste estudo verificar o efeito do isolamento nos anos de 2020 e 2021 sobre as taxas de incidência de sífilis e HIV/AIDS no município de Fernandópolis, SP. Foi realizado um estudo epidemiológico retrospectivo com abordagem quantitativa, utilizando dados do Painel de Indicadores Epidemiológicos do Ministério da Saúde, referentes ao Sistema de Agravo de Notificação (SINAN) para o período de 2019 a 2021. A análise comparou dados de um ano antes da pandemia com os anos durante o isolamento. Variáveis sociodemográficas e epidemiológicas foram analisadas por técnicas de estatística descritiva, considerando a frequência absoluta e relativa dos dados. Nos casos notificados de sífilis, observou-se predominância do sexo masculino, raça branca, faixa etária de 20 a 39 anos e escolaridade de ensino médio completo. Houve um aumento de casos de 2019 para 2020, mas uma diminuição significativa em 2021, ano com o maior número de mortes por COVID-19 e maior período de isolamento. Em relação à AIDS, o sexo masculino prevaleceu durante todos os anos estudados, com maior incidência em 2019 e 2021 na faixa etária de 35 a 49 anos e em 2020 entre 20 e 34 anos. A raça branca predominou em 2019 e 2020, mas não houve registros suficientes em 2021. A escolaridade mostrou igualdade entre as séries, com maior número de casos em 2020 para o ensino médio completo. O número de casos aumentou de 2019 para 2020, mas caiu cerca de 50% em 2021.
A prevenção primária como estratégia de combate à violência na Rota Ecológica dos Milagres
Authors: Figueirôa André Luís Souza de
Published: September 2024

O turismo é uma atividade socioeconômica complexa, suscetível a desafios internos, como a criminalidade e a violência. À vista disso, a prevenção primária emerge como a forma mais genuína e eficiente de abordar o fenômeno criminal, direcionando-se a toda a população. Refere-se a estratégias e intervenções direcionadas à eliminação ou redução das condições que propiciam a ocorrência de atividades criminosas antes que estas se manifestem. Nesse contexto, o objetivo central deste estudo foi analisar os benefícios da implementação das medidas de prevenção primária acerca da violência na região da Rota Ecológica dos Milagres, no Litoral Norte de Alagoas. Para tal finalidade, adotou-se a pesquisa exploratória e descritiva como delineamento metodológico, através da revisão bibliográfica, bem como a aplicação de formulários para militares e gestores municipais. Como efeito, constatou-se que a implementação eficaz de estratégias de prevenção primária da violência na região da Rota Ecológica dos Milagres requer o comprometimento e a colaboração de todos os atores envolvidos, incluindo forças de segurança, gestores municipais, comunidades locais e setor privado. Além disso, identificou-se que ao adotar uma abordagem integrada e baseada em evidências, é possível promover um ambiente seguro e acolhedor que estimule o desenvolvimento socioeconômico sustentável e o bem-estar de todos os indivíduos que vivem e visitam a região.
Büyük İskender’in Baktria ve Sogdiana Bölgelerindeki Seferleri Kapsamında İskitlerle Siyasi İlişkileri Üzerine Değerlendirmeler
Authors: Demir Muzaffer
Published: September 2024

III. Dareios, MÖ 331 yılında Gaugamela Savaşı’nda yenilgiye uğradıktan sonra Büyük İskender’in ordusuyla Ekbatana’daki sarayına yaklaştığı haberini almış ve Baktria satraplığına geri çekilmiştir. Yeniden toparlanarak karşı koyma sürecinde ordusu içinde huzursuzluklar belirmiş ve en yakın komutanı Bessos ve yanındakilerin ihanetine uğrayarak öldürülmüştür. İskender bu ihanetin baş lideri Bessos’un da peşinden gitmeye karar vermiştir. Ordusuyla MÖ 329 yılında Baktria Bölgesi’ne girmiştir. Bessos, meydan savaşı yapmaya cesaret edemeyerek Oxos Nehri’nin ötesine çekilmiş, Sogdiana yerel beyleri ve daha kuzeydeki İskitli müttefiklerinin de desteği ile gerilla savaşı yürütmeye karar vermiştir. İskender’in kararlılığını gören ve kendi bölgelerini de talan etmesini istemeyen yerel beyler Bessos’a da ihanet etmişler ve onu İskender’e teslim etmişlerdir. Buna rağmen sıranın kendilerine de geleceğini düşündüklerinden Spitamenes liderliğinde Baktrialı, Sogdialı ve İskitlerden oluşan ortak bir ayaklanma cephesi kurulmuştur. İskender, MÖ 327 yılına kadar devam eden ayaklanmaları bastırmada büyük zorluklarla karşılaşmış, her ne kadar India Seferi öncesinde önemli ölçüde etkisiz hale getirilseler de bölgede tam anlamıyla bir hakimiyet ve istikrar sağlanamamıştır. Şimdiye kadar yapılan günümüzdeki modern çalışmalarda İskitlerin bu ayaklanmalar esnasında oynadıkları rolün detaylı bir şekilde açıklanmadığı görülmektedir. Bu çalışmada İskitlerin savaş taktikleri ve bazı önemli diplomatik manevralarıyla İskender ve ordusunun tam bir zafer elde edememesinde önemli bir etken olduğu görüşü savunulmaktadır.
Sabazios: Köken ve Nitelik Tartışmaları
Authors: Türkan Ahmet
Published: September 2024

MÖ 5. yüzyıldan MS 4. yüzyıla kadar Akdeniz Dünyası’nın pek çok yerinde tapınım görmüş olan Tanrı Sabazios, ölüm, yeniden doğuş, bereket, kırsal yaşam, sağlık ve adalet gibi olgular ile ilişkilendirilmiştir. Pek çok metinde Dionysos ve Zeus ile bir tutulmasına karşın Hellen – Roma kültürel hakimiyeti dışında öz niteliklere, kült örgütlenmesine ve mitsel çeşitlemelere sahiptir. Tanrının kökeni ve özellikleri konusundaki tartışmalar hâlâ sürmektedir. Bu makalede söz konusu tartışmalar tanrının kökeni, tapınım coğrafyası, ikonografisi ve özellikleri başlıkları ile değerlendirilmiştir. Tanrının kökeni hakkındaki en güçlü savlar, onun Trakya, Anadolu ya da İran coğrafyasına ait olduğu yönündedir. Bunun yanında, tanrının Levant’tan gelmiş olabileceğini iddia eden bir görüş de vardır. Epigrafik ve arkeolojik kanıtların büyük bir kısmının Trakya ve Batı Anadolu’da bulunmuş olması bu iki bölgeyi öne çıkarmaktadır. Makalede, Sabazios’a bir Anadolu kökeni atfetmenin mümkün olmadığı savunulmakta ve Trakya kökenli olduğu tezi, kaynakların yeni yorumlarıyla desteklenmektedir. Bir başka tartışma alanı ise Sabazios’un özellikleri ve Hellen-Roma dünyasındaki diğer tanrılar ile olan ilişkisidir. Klasik Dönem’den Roma Dönemi’ne kadar pek çok yazar onu Dionysos ile bir tutmuştur. Buna karşılık epigrafik gelenekte Zeus ile ilişkilendirilmiştir. Tanrının ikonografisi ve sembolleri ise senkretik özellikler göstermektedir. Araştırmacıların çoğu, Sabazios’un Zeus ile olan ilişkisinden dolayı onun bir hava tanrısı olduğunu öne sürmüştür. Makalenin ikinci ve üçüncü kısımlarında bu tartışmalar değerlendirilmiş ve Sabazios’un bir yeraltı tanrısı ya da kahraman olabileceği yönünde yeni bir öneri ortaya koyulmuştur.
- PODCAST ROOM RESERVATION APPLICATION USING EXTREME PROGRAMMING METHOD
Authors: Matthew Randy , Lee Francka Sakti
Published: September 2024

In the era of globalization, information technology has become crucial in enhancing the productivity of information processing across various industries. Data management ensures smooth operations and informed decision-making. Podcasts have emerged as significant mediums for information consumption and entertainment, with an increasing number of listeners seeking high-quality content. Producing quality podcasts requires adequate facilities such as advanced recording equipment and acoustically suitable studio spaces. Development methodologies like Extreme Programming emphasize improving functionality and technical implementation. Reservations for podcast studios play a crucial role in scheduling recordings, with online booking systems enabling easy and efficient reservations, albeit requiring intensive individualized services. The capability of reservation systems to provide quick, accurate, and precise information can influence customer experiences and purchasing decisions. The integration of information technology and online reservations is key to optimizing podcast production and distribution, enhancing operational efficiency for service providers, while providing a satisfying experience for listeners. Although the system has yet to be fully implemented, it is designed to streamline booking processes and reduce manual intervention, which is anticipated to lead to significant improvements in both operational efficiency and customer satisfaction.
Detached tentacles of lion’s mane jellyfish Cyanea capillata can injure aquaculture fish
Authors: Sigurdsson GM , Lüskow F , Gislason A , Svavarsson J
Published: September 2024

Gelatinous zooplankton can cause fish mortalities and economic losses for aquaculture companies. While protective measures against jellyfish blooms are increasingly implemented, free-floating tentacles have not been considered. Tentacles with active cnidocysts, both whole and fragmented, can cause potential damage to fish for an unknown duration after the jellyfish bloom has passed. In this pilot study, we measured for how long detached tentacles of the lion’s mane jellyfish Cyanea capillata can cause injuries/catch zooplankton prey. Controlled experiments were conducted in late summer 2007 using in situ collected specimens from northern Iceland. Jellyfish tentacles maintained their full ability to capture brine shrimps Artemia salina for 24 d. However, no prey could be immobilised from Day 26 onwards. To our knowledge, this is the first experimental evidence showing how long cnidocysts in tentacles can catch prey and thus potentially harm aquaculture fish after detachment (about 3.5 wk); this information should be considered when making any hypothetical risk assessment.
The Effectiveness of Communicative and Test-Focused Approaches in TOEFL® Preparation Classes
Authors: Farid Achmad , Yusuf Adi , Qani’ah Binti
Published: September 2024

This study investigates the effectiveness of the Communicative Approach and the Test-Focused Approach in TOEFL® preparation classes. Sixty-four students from Islamic Senior High School Madrasah Aliyah Al-Insan (pseudonym) in Jombang, East Java, Indonesia, were divided into two groups: one receiving instruction based on the Communicative Approach and the other on the Test-Focused Approach. Using a quasi-experimental design, pre-test and post-test scores were analyzed to measure improvements in TOEFL performance. The results showed significant score increases in both groups. The Communicative Approach group’s mean pre-test score of 456 improved to 483 post-intervention, while the Test-Focused Approach group’s mean score rose from 460 to 493. The paired sample t-test results indicated statistically significant improvements within each group, with p-values of 0.00 for the Communicative Approach and 0.00 for the Test-Focused Approach. Additionally, the independent sample t-test revealed that the Test-Focused Approach group performed significantly better than the Communicative Approach group post-intervention, with a p-value of 0.030. These findings align with existing theories on language learning and test preparation, suggesting that while communicative methods enhance overall language proficiency, test-focused strategies more effectively boost immediate test performance. The study concludes that integrating both approaches in TOEFL preparation programs can provide a balanced and comprehensive strategy, optimizing both language development and test readiness. Future research should explore the long-term effects of such integrated methods on students' language proficiency and academic success.
Analysing the Meaning of Audience for Cross-gender Artists in the Documentary Lelaki Ayu Primadona Java: Lengger Lanang
Authors: Ujiningtyas Safira Nur
Published: September 2024

Lengger Lanang is a traditional Javanese dance performed by a group of men that dress like women. This tradition might clash with a conservative Indonesian culture that considers cross-dressing men as deviant. This research aims to analyze how a group of people perceive a documentary film titled Lelaki Ayu Primadona Jawa: Lengger Lanang about a group of Lengger Lanang dancers. Using Stuart Hall’s encoding-decoding theory, this research involved seven informants who were divided into three groups of reader positions: dominant, negotiation and opposition. This research used a descriptive qualitative research design which focuses on the audience's reading position by analyzing the audience's understanding of cross-gender artists through documentary film scenes. Data was obtained from in-depth interviews with the informants. The research results showed that four informants who were in dominant positions and three informants who were in negotiating positions, and there were no audience members who were in opposition positions. The audience's reading position is influenced by the background of the audience watching the documentary. The audience interprets this documentary as an understanding of artists across gender but also discusses the preservation of the culture, history and values ​​of the Lengger Lanang dancers.
Una cartografía (¿posible?) de las movilidades migratorias de las personas transfemeninas y travestis en Argentina
Authors: Darouiche Cristian Alejandro
Published: September 2024

El siguiente trabajo sugiere abandonar el concepto de migraciones trans* y/o exilio como nombramiento de los desplazamientos geográficos de personas transfemeninas y travestis, proponiendo conceptualizar tales desplazamientos geográficos como movilidades migratorias. Para ejemplificar el uso del concepto propuesto se dan a conocer los datos de un trabajo de campo etnográfico realizado con transfeminidades de la ciudad de Mar del Plata, en Argentina. Esa investigación buscó relevar las condiciones materiales de vida y los factores que obligaban y/o empujaban a la migración. El dato principal es que la movilidad aparece como un hito en sus biografías, pero que, además, se la concibe como un proyecto abierto de varios movimientos, y de idas y venidas concebidas como retornos. Este trabajo apuesta al concepto de movilidad migratoria, ya que habilita dos aristas nuevas de análisis sobre los desplazamientos geográficos de las personas transfemeninas.
THE ROLE OF CIVIL SERVICE POLICE UNIT IN ENFORCING HYGIENE LAWS IN PALU CITY, CENTRAL SULAWESI
Authors: Gaghauna Vanessa Gloria , Tan Anselmus
Published: September 2024

The increase in the population of Palu City has implications for increasing community activities and affecting waste generation, if it cannot be managed properly it will cause various problems. The regulations issued by the Palu City government which prohibit people from littering are often ignored. This research aims to analyze and describe the role of the Palu City Satpol-PP in enforcing regional legal products regarding waste management and cleanliness by identifying and analyzing supporting and inhibiting factors, as well as what efforts are being made. This research employed a descriptive method with a qualitative approach. Data collection techniques were conducted through interviews, observations, and document studies. The results of this research show that the Palu City Civil Service Police Unit has carried out its role well as a regional law enforcer regarding cleanliness, in this case, its role as a stabilizer, innovator, modernizer, and pioneer. However, there are still several obstacles, including a lack of public awareness and limited Civil Servant Investigator personnel. Thus, the Palu City Civil Service Police Unit is intensively carrying out outreach and counselling to the community and business actors, taking a humanist and persuasive approach, as well as increasing the number of Civil Servant Investigators.
ENFORCEMENT OF SINTANG REGENCY REGIONAL REGULATION NUMBER 13 OF 2017 CONCERNING PUBLIC ORDER BY THE SINTANG REGENCY PAMONG PRAJA POLICE UNIT
Authors: Riyanto Maria Angela , Dananjaya Gede Bhayu
Published: September 2024

Sintang Regency still faces problems in the context of public order, primarily related to alcoholic beverage business licenses. This study aims to describe and analyze the enforcement of Sintang Regency Regional Regulation Number 13 of 2017 concerning Public Order by the Sintang Regency Pamong Praja Police Unit, specifically regarding alcoholic beverage business licenses. The research method is descriptive-qualitative. The results showed that in carrying out the duties and functions of enforcing regional regulations, the Satpol PP of Sintang Regency faced problems related to the lack of public understanding of obtaining business licenses and also the Pamong Praja Police Unit, which did not provide sufficient understanding to the public regarding related regional regulations. In conclusion, the enforcement of Sintang Regency Regional Regulation Number 13 of 2017 concerning Public Order by the Sintang Regency Pamong Praja Police Unit is quite well implemented. It needs to be strengthened in several aspects, including by conducting intense socialization activities, strengthening leadership commitment, and employee participation in training activities relevant to duties and functions.
PENGARUH KECERDASAN EMOSIONAL, PERILAKU BELAJAR TERHADAP TINGKAT PEMAHAMAN AKUNTANSI DENGAN KEPERCAYAAN DIRI SEBAGAI VARIABEL PEMODERASI PADA PERGURUAN TINGGI SWASTA DI BATAM
Authors: Efriyenti Dian
Published: September 2024

Abstract This study is expected for accounting students to be confident that affects empathy, because students who have high confidence will be easy to empathize with others. The sign of a student understanding of accounting is not only shown from the values obtained in the course but also if the student is to follow and be able to master the concepts related, accounting science that has been acquired so far can be applied in social life or in other words in practice the world of work. Research sample at University of Riau Islands, University of Batam and International University of Batam amounted to 82 respondents. The results showed the results of emotional intelligence and learning behavior partially and simultaneously affect the level of understanding of accounting. While confidence moderate the relationship between emotional intelligence with the level of understanding of accounting, but not significant with t arithmetic results obtained - 1.029 greater than t table -1,990, or Sig value 0.307> 0.05. Confidence moderates the relationship between learning behavior with the level of understanding of accounting, but not significant.Keywords: Emotional Intelligence, Learning Behavior, Level of Understanding Accounting, Self Confidence.Abstrak Penelitian ini diharapkan agar mahasiswa akuntansi menjadi percaya diri yang mempengaruhi empati, karena siswa yang memiliki kepercayaan diri tinggi akan mudah berempati dengan orang lain. Tanda pemahaman mahasiswa akuntansi tidak hanya ditunjukkan dari nilai-nilai yang diperoleh dalam mata kuliah tetapi juga jika siswa tersebut mengikuti dan dapat menguasai konsep-konsep terkait, ilmu akuntansi yang telah diperoleh selama ini dapat diterapkan dalam kehidupan sosial atau dengan kata lain dalam praktek dunia kerja. Sampel penelitian di Universitas Kepulauan Riau, Universitas Batam dan Universitas Internasional Batam berjumlah 82 responden. Hasil penelitian menunjukkan hasil kecerdasan emosional dan perilaku belajar secara parsial dan simultan berpengaruh terhadap tingkat pemahaman akuntansi. Sedangkan kepercayaan memoderasi hubungan antara kecerdasan emosional dengan tingkat pemahaman akuntansi, tetapi tidak signifikan dengan hasil t hitung diperoleh - 1,029 lebih besar dari t tabel -1,990, atau nilai Sig 0,307> 0,05. Keyakinan memoderasi hubungan antara perilaku belajar dengan tingkat pemahaman akuntansi, tetapi tidak signifikan.Kata Kunci: Kecerdasan Emosional, Perilaku Belajar, Tingkat Pemahaman Akuntansi, Kepercayaan Diri
PENGELOLAAN LINGKUNGAN KERJA DAN STRESS KERJA TERHADAP KINERJA KARYAWAN
Authors: Frianto Agus
Published: September 2024

Abstract: In any organization, human resources has an important role in achieving efficiency and effectiveness of the organization by managing physical resources, financial, and human beings in the most effective and efficient. Extrinsic Motivation and Work Environment is one of the factors that can affect the performance of the employees. Mechanical sampling using simple random sampling with a sample of 150 respondents. This research used SPSS (Statistic Program for Social System) version 23 for windows. Based on causality test found a significant positive effect of the work environment and work stress on employee performance with T-statistic values of 4,376 and 4,393.The results showed that the magnitude of the effect of the work environment and work stress on employee performance by 66.2% while the remaining 33.8% is influenced by other variables.Keywords: Work Environment, Work Stress and Employee PerformanceAbstrak: Dalam setiap organisasi, sumber daya manusia memiliki peranan penting dalam pencapaian efisiensi dan efektifitas organisasi dengan mengelola sumber daya fisik, keuangan, dan manusia dalam cara yang paling efektif dan efisien. Motivasi Ekstrinsik dan Lingkungan Kerja merupakan salah satu faktor yang dapat mempengaruhi kinerja karyawan. Penelitian ini bertujuan untuk menguji dan menganalisis apakah motivasi ekstrinsik dan lingkungan kerja berpengaruh terhadap kinerja karyawan. Teknik pengambilan sampel menggunakan teknik simple random sampling dengan jumlah sampel 150 responden. Penelitian ini menggunakan software SPSS (Statistic Program for Social System) versi 23 for windows. Berdasarkan uji kausalitas didapatkan pengaruh yang signifikan positif lingkungan kerja dan stress kerja terhadap kinerja karyawan dengan nilai T-statistik sebesar 4,376 dan 4,393. Hasil penelitian menunjukkan bahwa besarnya pengaruh lingkungan kerja dan stress kerja terhadap kinerja karyawan sebesar 66,2% sedangkan sisanya 33,8% dipengaruhi oleh variabel lain.Kata kunci : Lingkungan Kerja, Stress Kerja dan Kinerja Karyawan
Peluang dan Tantangan Pada Industri Rumah Tangga Kuliner: Tinjauan Literatur
Authors: Malihah Lola , Sari Aji Nur , Zaitun
Published: September 2024

Persaingan adalah bagian yang tidak terpisahkan dalam sebuah bisnis. Setiap pelaku usaha selalu berupaya untuk menarik minat konsumen sebanyak mungkin dan memenangkan pesaingan pasar. Industi rumah tangga adalah bagian dari Usaha Mikro, Kecil, Menengah yang sering disebut berperan besar dalamg perekonomian Indonesia. Dalam menjalankan bisnisnya para pelaku usaha ini juga harus menerapkan strategi yang tepat untuk menghadapi persaingan dan agar tetap dapat bertahan. Tulisan ini merupakan sebuah tinjauan pustaka yang bertujuan untuk mengetahui peluang dan tantangan dalam menerapkan strategi pemasaran oleh pelaku usaha kuliner. Data dalam tulisan ini berupa data sekunder yang diperoleh dari kajian pustaka yang relevan dengan tema yaitu peluang dan tantangan yang dihadapi para pelaku usaha kuliner. Hasil dari analisis ini menunjukkan bahwa adanya persaingaan sehingga para pelaku industri rumah tangga bidang kuliner ini berusaha mempertahankan kualitas produk dengan selalu menggunakan bahan baku yang bermutu dan tidak menggunakan bahan pengawet, pewarna dan pemanis buatan yang berbahaya bagi kesehatan. Harga yang ditawarkan juga masih relatif murah, memilih tempat berjualan yang strategis sehingga memudahkan konsumen untuk membeli. Adanya usaha rumah tangga ini juga berpeluang meciptakan lapangan pekerjaan, penopang perekonomian daerah dan ekonomi nasional serta dapat menjadi upaya pelestarian kuliner nusantara. Sedangkan tantangannya adalah adanya digitalisasi dimana penjual juga menawarkan pembelian berbasis online serta melakukan promosi pada berbagai media, termasuk promosi melalui media sosial.  Memiliki sumber daya manusia yang memahami teknologi dan aplikasi digital baik untuk promosi ataupun untuk transaksi keuangan.
Analisis Halal Value Chain Pelaksanaan Self Declare di Halal Center
Authors: Laila Rahma Qumil , Alim Mohammad Nizarul
Published: September 2024

Pelaksanaan sertifikasi halal khususnya self-declare harus memperhatikan value chain yang dilakukan oleh para aktor. Karena adanya beberapa permasalahan dan hambatan yang terjadi, maka value chain menjadi sangat penting. Penelitian ini bertujuan untuk mendeskripsikan bagaimana sistem self-declare dari perspektif analisis halal value chain serta beberapa permasalahan dalam proses self-declare di halal center. Penelitian ini mengaplikasikan pendekatan kualitatif serta jenis penelitian deskriptif. Hasil penelitian menunjukkan bahwa tiga lembaga dan wewenangnya terkait dengan self-declare telah diidentifikasi yaitu BPJPH, MUI, dan LP3H. Value chain untuk self-declare dianalisis melalui tiga aspek yaitu proses, informasi dan aktor. Enam proses dalam pengajuan self-declare melibatkan berbagai aspek informasi dari pelaku usaha. Informasi tersebut melibatkan informasi pelaku usaha, produk, proses, dan lokasi produksi. Pelaku usaha, pendamping PPH, BPJPH, dan komite fatwa produk halal merupakan aktor yang terlibat dalam proses pengajuan self-declare. Permasalahan yang muncul dalam proses pengajuan self-declare di halal center yaitu inefisiensi operasional yang disebabkan oleh pelaku usaha dan pendamping PPH.
Popular Reactions to Donald Trump’s Indictments and Trials and their Implications for the 2024 Election
Authors: Jacobson Gary
Published: September 2024

The sharp momentum shifts in the presidential contest during the summer of 2024—induced by Joe Biden’s disastrous debate performance, Donald Trump’s attempted assassination, Biden’s withdrawal and the subsequent surge in support for Kamala Harris—have overshadowed the most striking feature of the 2024 election: Donald Trump’s return from exile in Mar-a-Lago to win easy nomination and a serious chance of returning to the White House despite the ignominy of the January 6, 2021, Capitol invasion, felony indictments in four jurisdictions (with convictions on all 34 counts in one of them), and losses in three civil suits since his departure from the White House 2021. This paper documents and attempts to explain this reality through analysis of hundreds of surveys probing reactions to Trump’s criminal charges and civil suits, with an eye to gauging their potential role in shaping voting choices in 2024. mp
Inverse problem for semilinear wave equation with strong damping
Authors: Protsakh Nataliya
Published: September 2024

The initial-boundary and the inverse coefficient problems for the semilinear hyperbolic equation with strong damping are considered in this study. The conditions for the existence and uniqueness of solutions in Sobolev spaces to these problems have been established. The inverse problem involves determining the unknown time-dependent parameter in the right-hand side function of the equation using an additional integral type overdetermination condition.
Autophagy and the pancreas: Healthy and disease states
Authors: Zhou Zixian , Zhang Pengcheng , Li Juan , Yao Jiaqi , Jiang Yuhong , Wan Meihua , Tang Wenfu , Liu Ling
Published: September 2024

Macroautophagy/autophagy is an intracellular degradation pathway that has an important effect on both healthy and diseased pancreases. It protects the structure and function of the pancreas by maintaining organelle homeostasis and removing damaged organelles. A variety of pancreas-related diseases, such as diabetes, pancreatitis, and pancreatic cancer, are closely associated with autophagy. Genetic studies that address autophagy confirm this view. Loss of autophagy homeostasis (lack or overactivation) can lead to a series of adverse reactions, such as oxidative accumulation, increased inflammation, and cell death. There is growing evidence that stimulating or inhibiting autophagy is a potential therapeutic strategy for various pancreatic diseases. In this review, we discuss the multiple roles of autophagy in physiological and pathological conditions of the pancreas, including its role as a protective or pathogenic factor.
Topological indices based VIKOR assisted multi-criteria decision technique for lung disorders
Authors: Ashraf Tahreem , Idrees Nazeran
Published: September 2024

Lung disorders involve swelling, inflammation, and muscle tightening around the airways, with symptoms such as coughing, wheezing, shortness of breath, and abnormal fluid build-up. The global prevalence of these conditions is rising, highlighting the need for extensive research to alleviate their severity and symptoms. Due to the chronic nature and recurrence of these disorders, the human body often develops immunity and side effects to certain medications. Therefore, developing novel and appropriate drug combinations is crucial. This study analyzes a dataset of lung disorder drugs, characterized by various topological indices. The structures of 16 drugs used to treat lung disorders are correlated with their physical properties using degree-based graph invariants. When considering specific attributes, the VIKOR (VlseKriterijumska Optimizacija I Kompromisno Resenje) method provides an optimal ranking for each drug. The QSPR results highlight the effectiveness of this approach in drug prioritization, offering valuable insights for clinical decision-making and drug development. This methodology can enhance the strategic selection of treatments for lung disorders, leading to improved patient care and better resource allocation.
Comparison of branched, fenestrated, and parallel strategies for endovascular treatment of thoracoabdominal aortic pathologies involving visceral regions
Authors: Ma Xiaochen , Wu Zhishi , Zhu Guanglang , Guo Mingjin , Li Yongxin , Liu Junjun , Liu Mingyuan , Li Youjin , Ye Bo , Chen Tao , Qi Ming , Xiao Hongyan , Zeng Zhaoxiang , Sun Yudong , Feng Rui , Jing Zaiping , Feng Jiaxuan
Published: September 2024

Purpose

To compare the long-term efficacy of the parallel stent graft (PSG), fenestrated stent graft (FSG), and branched stent graft (BSG) techniques to treat thoracoabdominal aortic pathologies.

Materials and methods

In total, 291 patients with thoracic aortic aneurysm (TAA) and dissection (TAD) involving visceral arteries who underwent PSG (n = 85; 15 TAA and 70 TAD), FSG (n = 107; 47 TAD and 60 TAA), or BSG (n = 99; 37 TAD and 62 TAA) were included from multiple centers from January 2015 to December 2022, and a total of 1,108 visceral aortic branches were reconstructed.

Results

The average reconstruction time of each visceral aortic branch for FSG, BSG, and PSG is 27.5 ± 12.1, 23.2 ± 11.9, and 18.8 ± 11.8 min, respectively (P < 0.01). The free-from-endoleak rate at the last follow-up for FSG, BSG, and PSG was 86.9%, 91.9%, and 60.0%, respectively. The last follow-up patency rate for FSG, BSG, and PSG was 85.0%, 91.9%, and 94.1%, respectively. The average reconstruction price of each visceral aortic branch for FSG, BSG, and PSG was 41.40 ± 3.22 thousand RMB, 41.84 ± 3.86 thousand RMB, and 42.35 ± 4.52 thousand RMB, respectively (P = 0.24).

Conclusion

To treat the aortic pathologies involving the visceral segment, BSG had a lower endoleak rate and higher branch patency rate when compared with the FSG and PSG techniques. The expense of BSG was comparable to the other two techniques.
Reproductive outcomes in fresh transfer cycles and antagonists with premature luteinizing and/or progesterone surge: a single center retrospective cohort study
Authors: Wei Chun-Xiao , Zhang Jian-Wei , Xiang Shan , Lian Fang
Published: September 2024

Background

The optimal outcome of assisted reproductive technology is a successful live birth after fresh embryo transfer. However, the success pregnancy rate of fresh embryo transfer cycle in antagonist protocol is lower than that observed in other protocols. Despite the use of antagonists (GnRH-ant), the incidence of luteinizing hormone surge and elevated progesterone levels remain at approximately 5%-38%. Progesterone is widely recognized to exert adverse effects on fresh embryo transfer outcomes. This study aimed to investigate the impact of luteinizing hormone surge and progesterone levels on live birth rate following fresh embryo transfer and explore appropriate progesterone thresholds to enhance pregnancy outcomes.

Methods

This retrospective cohort study included a total of 1,177 antagonist protocol cycles with fresh embryo transfer. The patients were divided into four groups based on the presence of premature LH surge and progesterone level on trigger day>1.5ng/ml. Then, the relationship between the variables and the pregnancy outcome was analyzed and compared in each group.

Results

The transient rise of luteinizing hormone did not impact pregnancy outcomes (P=0.345; P=0.3; P=0.787), in contrast to progesterone levels on the day of hCG administration (P=0.047*; P=0.015*; P=0.021*). In cases with luteinizing hormone surge, elevated progesterone levels were correlated with higher antral follicle count (AFC), and as progesterone levels increased, a greater quantity of oocytes and embryos were obtained. However, there was no statistically significant difference in pregnancy outcomes. In cases without luteinizing hormone surge, elevated progesterone levels led to significantly poorer pregnancy outcomes. Furthermore, the curve-fitting and threshold-effect analysis revealed a notable decline in live birth rates when progesterone exceeded or equaled 1.10ng/ml (OR, 0.25; 95% CI, 0.09–0.66; P = 0.005*).

Conclusion

The GnRH-ant dosage addition should be carefully selected in flexible antagonist protocols. The presence of elevated progesterone levels may be associated with improved embryo quality when luteinizing hormone surge occurred. In the absence of a luteinizing hormone surge, progesterone levels showed a larger impact on the pregnancy outcome, and fresh embryo transfer should not be performed if the progesterone level on the day of hCG administration is higher than 1.10ng/ml.
Nonlinear relationship between triglyceride-glucose index and the risk of prediabetes and diabetes: a secondary retrospective cohort study
Authors: Cao Changchun , Hu Haofei , Xiao Peng , Zan Yibang , Chang Xinru , Han Yong , Zhang Xiaohua , Wang Yulong
Published: September 2024

Background

The triglyceride-glucose (TyG) index, recognized for its cost-efficiency and simplicity, serves as an accessible indicator of insulin resistance. Yet, its correlation with the risk of prediabetes and diabetes (Pre-DM/DM) in the Chinese demographic remains uncertain. Consequently, our study explored the association between the TyG index and the development of Pre-DM/DM within the Chinese population.

Methods

The retrospective cohort study was carried out utilizing data from a health screening initiative. The study included 179541 adults over 20 who underwent medical examinations at the Rich Healthcare Group over a period spanning from 2010 to 2016. The correlation between the TyG index and Pre-DM/DM risk was investigated using Cox regression analysis. Furthermore, Cox proportional hazards regression with cubic spline functions and smooth curve fitting was incorporated to explore their non-linear connection.

Results

The mean age of study participants was 41.18 ± 12.20 years old, and 95255 (53.05%) were male. During a median follow-up of 3.01 years, 21281 (11.85%) participants were diagnosed with Pre-DM/DM. After adjusting the potential confounding factors, the results showed that the TyG index was positively correlated with incident Pre-DM/DM (HR: 1.67, 95%CI: 1.62-1.71, P< 0.001). Additionally, a non-linear association was observed between the TyG index and the onset of Pre-DM/DM, with an inflection point identified at 8.73. Hazard ratios (HR) to the left and right of this inflection point were 1.95 (95%CI: 1.86-2.04) and 1.34 (95%CI: 1.27-1.42), respectively. Furthermore, sensitivity analyses confirmed the stability of these findings.

Conclusion

The TyG index exhibited a non-linear positive relationship with the risk of Pre-DM/DM. These findings imply that maintaining the TyG index at a lower, specified threshold may be beneficial in mitigating the onset of Pre-DM/DM.
Interleukin signaling in the regulation of natural killer cells biology in breast cancer
Authors: Xu Jiachi , Gao Hongyu , Azhar Muhammad Salman , Xu Haifan , Chen Siyuan , Li Mingcan , Ni Xinxi , Yan Ting , Zhou Hui , Long Qian , Yi Wenjun
Published: September 2024

In the field of breast cancer treatment, the immunotherapy involving natural killer (NK) cells is increasingly highlighting its distinct potential and significance. Members of the interleukin (IL) family play pivotal regulatory roles in the growth, differentiation, survival, and apoptosis of NK cells, and are central to their anti-tumor activity. These cytokines enhance the ability of NK cells to recognize and eliminate tumor cells by binding to specific receptors and activating downstream signaling pathways. Furthermore, interleukins do not function in isolation; the synergistic or antagonistic interactions between different interleukins can drive NK cells toward various functional pathways, ultimately leading to diverse outcomes for breast cancer patients. This paper reviews the intricate relationship between NK cells and interleukins, particularly within the breast cancer tumor microenvironment. Additionally, we summarize the latest clinical studies and advancements in NK cell therapy for breast cancer, along with the potential applications of interleukin signaling in these therapies. In conclusion, this article underscores the critical role of NK cells and interleukin signaling in breast cancer treatment, providing valuable insights and a significant reference for future research and clinical practice.
Novel prognostic signature for hepatocellular carcinoma using a comprehensive machine learning framework to predict prognosis and guide treatment
Authors: Zheng Shengzhou , Su Zhixiong , He Yufang , You Lijie , Zhang Guifeng , Chen Jingbo , Lu Lihu , Liu Zhenhua
Published: September 2024

Background

Hepatocellular carcinoma (HCC) is highly aggressive, with delayed diagnosis, poor prognosis, and a lack of comprehensive and accurate prognostic models to assist clinicians. This study aimed to construct an HCC prognosis-related gene signature (HPRGS) and explore its clinical application value.

Methods

TCGA-LIHC cohort was used for training, and the LIRI-JP cohort and HCC cDNA microarray were used for validation. Machine learning algorithms constructed a prognostic gene label for HCC. Kaplan–Meier (K-M), ROC curve, multiple analyses, algorithms, and online databases were used to analyze differences between high- and low-risk populations. A nomogram was constructed to facilitate clinical application.

Results

We identified 119 differential genes based on transcriptome sequencing data from five independent HCC cohorts, and 53 of these genes were associated with overall survival (OS). Using 101 machine learning algorithms, the 10 most prognostic genes were selected. We constructed an HCC HPRGS with four genes (SOCS2, LCAT, ECT2, and TMEM106C). Good predictive performance of the HPRGS was confirmed by ROC, C-index, and K-M curves. Mutation analysis showed significant differences between the low- and high-risk patients. The low-risk group had a higher response to transcatheter arterial chemoembolization (TACE) and immunotherapy. Treatment response of high- and low-risk groups to small-molecule drugs was predicted. Linifanib was a potential drug for high-risk populations. Multivariate analysis confirmed that HPRGS were independent prognostic factors in TCGA-LIHC. A nomogram provided a clinical practice reference.

Conclusion

We constructed an HPRGS for HCC, which can accurately predict OS and guide the treatment decisions for patients with HCC.
Activation of pro-resolving pathways mediate the therapeutic effects of thymosin beta-4 during Pseudomonas aeruginosa-induced keratitis
Authors: Wang Yuxin , Banga Loveleen , Ebrahim Abdul Shukkur , Carion Thomas W. , Sosne Gabriel , Berger Elizabeth A.
Published: September 2024

Introduction

Current treatments for bacterial keratitis fail to address the sight-threatening inflammatory host response. Our recent work elucidating the therapeutic mechanisms of adjunctive thymosin beta-4 (Tβ4) in resolving inflammation and infection in bacterial keratitis revealed modulation of effector cell function and enhanced bacterial killing. The current study builds upon the observed effects on effector cell function by investigating the impact of Tβ4 on specialized pro-resolving lipid mediator (SPM) pathways as they play a significant role in inflammation resolution.

Methods

Using a well-established in vivo model of Pseudomonas aeruginosa-induced bacterial keratitis, we assessed key enzymes (5-LOX and 12/15-LOX) involved in SPM pathway activation, SPM end products (lipoxins, resolvins), and receptor levels for these mediators. In vitro validation using LPS-stimulated murine monocyte/MΦ-like RAW 264.7 cells and siRNA to inhibit Tβ4 and LOX enzymes was carried out to complement our in vivo findings.

Results

Findings from our in vivo and in vitro investigations demonstrated that adjunctive Tβ4 treatment significantly influences enzymes and receptors involved in SPM pathways. Further, Tβ4 alone enhances the generation of SPM end products in the cornea. Our in vitro assessments confirmed that Tβ4-enhanced phagocytosis is directly mediated by SPM pathway activation. Whereas Tβ4-enhanced efferocytosis appeared to be indirect.

Conclusion

Collectively, these findings suggest that the therapeutic effect of Tβ4 resolves inflammation through the activation of SPM pathways, thereby enhancing host defense and tissue repair. Our research contributes to understanding the potential mechanisms behind Tβ4 immunoregulatory function, pointing to its promising ability as a comprehensive adjunctive treatment for bacterial keratitis.
Characterisation and Immunogenicity of Neisseria cinerea outer membrane vesicles displaying NadA, NHBA and fHbp from Neisseria meningitidis serogroup B
Authors: Manoharan Shathviga , Farman Theo A. , Piliou Stavroula , Mastroeni Pietro
Published: September 2024

More affordable and effective vaccines against bacterial meningitis caused by Neisseria meningitidis serogroup B are still required for global prevention. We have previously shown that modified outer membrane vesicles (mOMVs) from commensal Neisseria cinerea can be used as a platform to induce immune responses against meningococcal antigens. The aim of the present study was to use a combination of two genetically engineered mOMVs to express multiple antigens from N. meningitidis known to be involved in protective immunity to meningococcal meningitis (different variants of factor H binding protein (fHbp), Neisseria Heparin Binding Antigen (NHBA) and Neisseria Adhesin A (NadA)). Antigen expression in the mOMVs was confirmed by Western blotting; detoxification of the lipooligosaccharide (LOS) was confirmed by measuring human Toll-like receptor 4 (hTLR4) activation using in vitro cell assays. Mice immunised with a combination of two mOMVs expressing fHbp, NHBA and NadA produced antibodies to all the antigens. Furthermore, serum bactericidal activity (SBA) was induced by the immunisation, with mOMVs expressing NadA displaying high SBA titres against a nadA+ MenB strain. The work highlights the potential of mOMVs from N. cinerea to induce functional immune responses against multiple antigens involved in the protective immune response to meningococcal disease.
Assessing the vulnerability of sensitive species in Mediterranean fisheries: insights from productivity-susceptibility analysis
Authors: Li Veli Daniel , Barrionuevo Jose Carlos Baez , Bargione Giada , Barone Giulio , Bdioui Marouene , Carbonara Pierluigi , Fahim Reda Magdy , Follesa Maria Cristina , Gökçe Gökhan , Mahmoud Hatem Hanafy , Ligas Alessandro , Idrissi Mohammed Malouli , Moramarco Giulia , Panayotova Marina , Petetta Andrea , Sacchi Jacques , Tsagarakis Konstantinos , Virgili Massimo , Lucchetti Alessandro
Published: September 2024

Mortality resulting from interactions with fishing gears represent an important threat to sensitive species globally. In this study, we address this issue by defining five species groups of marine megafauna (marine mammals, seabirds, demersal and pelagic elasmobranchs, and sea turtles), and conducting a productivity-susceptibility analysis (PSA) within the context of data-limited fisheries in the Mediterranean and Black Sea. Although there are significant differences among species within each group, this approach has been considered much more direct and functional for management purposes. The productivity (P) of each species group was determined by evaluating a set of attributes averaged across representative species within each group. Species groups’ susceptibility (S) to bycatch was assessed through a comprehensive review of existing literature and expert judgment, considering a series of semi-quantitative attributes. Our analysis identified areas and fishing gears posing potential risks to the species groups assessed, highlighting that sea turtles and elasmobranchs face the potential risk of incidental captures from various fishing gears operating in both neritic (bottom trawls, set nets and bottom longlines) and pelagic (drifting longlines) environments. Marine mammals exhibit moderate risk across most fishing gears, with particular concern for the harbour porpoise Phocoena phocoena relicta in the Black Sea, primarily due to the interaction with set nets, which can severely impact entire population even capturing few specimens due the species low productivity. Seabirds face reduced impact with fishing activities, irrespective of the type of gear examined or the specific area under investigation. Overall, our study highlights the specific basins and fishing gears requiring focused management measures, mitigation strategies, and enhanced monitoring activities to mitigate the impacts of bycatch on vulnerable marine megafauna.
Assessing the changes in marine microalgae diversity in the Nanji Islands Nature Reserve over the past decades using sediment eDNA
Authors: Li Haotian , Xu Alan Ningyuan , Yang Zaibao , Lei Yanli , Chen Jiaxin , Zhan Zifeng , Xu Kuidong , Li Tiegang , Xie Shangwei
Published: September 2024

The Nanji Islands, designated as one of China’s national nature reserves, are renowned for their abundant microalgal resources. Changes in microalgae can serve as indicators of marine environmental shifts. Despite this significance, the absence of comprehensive historical records on microalgal diversity has limited the evaluation of marine environmental protection efforts. This study addresses this gap by analyzing surface sediments and sediment cores from the Nanji Islands, utilizing 210Pb dating and employing environmental DNA (eDNA) technology to trace historical shifts in the molecular diversity of microalgae. Chloroplast gene fragments were amplified using rbcL primers, and 210Pb dating determined the deepest sediment layer (78-80 cm) to date back to 1994. From the 70-72 cm layer to the 60-62 cm layer, the number of microalgal reads increased rapidly from 27,716 to 65,143, signifying enhanced abundance over the 10 years following the establishment of the nature reserve. This was followed by a deceleration in microalgal abundance growth over the subsequent 20 years, potentially reflecting variations in primary production of microalgae. Concurrently, the rise in operational taxonomic units (OTUs) and the Margalef index suggest a boost in microalgal diversity, which may be attributed to improvements in the marine environment. The microalgal community composition has shifted from a dominance of Dinoflagellata and Streptophyta to a predominance of Bacillariophyta, the change in phosphate would be one of the impact factors worth noting. This study provides foundational data on the historical changes in microalgae in the Nanji Islands and serves as a reference for exploring the relationship between environmental conditions and microalgal dynamics.