bluuebunny/crossref_metadata_2025 huggingface dataset:
COVID-19 y el mercado laboral de Lima Metropolitana y Callao: Un análisis de género
Authors: Paredes Tania
Published: November 2023

Esta investigación analiza el impacto de las medidas de cuarentena por el COVID-19 en el empleo en Lima Metropolitana y Callao en 2020, con énfasis en las diferencias de género. Se utilizaron datos de la Encuesta Permanente de Empleo (EPE) para analizar las horas de trabajo semanales y los salarios por hora, considerando factores como la estructura del hogar y el mercado laboral. Los resultados mostraron una disminución en las horas de trabajo semanales tanto para hombres como para mujeres debido al COVID-19, con un mayor impacto en las mujeres jefas de hogar. Sin embargo, se observó un aumento en las horas trabajadas para mujeres con empleos esenciales y hombres en el sector formal. En cuanto a los ingresos por hora, las mujeres experimentaron una reducción significativa en contraste con los hombres. El incremento en los ingresos por hora se destacó en hombres con empleos esenciales y mujeres en el sector formal.
La Era Digital en la Química Farmacéutica: Transformando el Diseño de Medicamentos con Métodos Computacionales
Authors: Valdiviezo Jesus
Published: November 2023

El diseño de medicamentos se ha beneficiado significativamente de los avances en la química computacional y las redes neuronales. En este artículo, exploramos el papel fundamental que desempeñan técnicas de la química computacional como la Teoría del Funcional de la Densidad (DFT), el Docking Molecular y la Dinámica Molecular (MD) en la comprensión y optimización de interacciones a nivel atómico y molecular. Además, examinamos cómo la integración de redes neuronales ha impulsado la precisión y eficiencia en el diseño de fármacos. Presentamos ejemplos concretos de proyectos de investigación que demuestran la sinergia entre estos métodos y destacan avances significativos en la búsqueda de soluciones médicas efectivas. Asimismo, discutimos los desafíos y consideraciones clave para seguir avanzando en este campo multidisciplinario.
Variables asociadas al regreso a clases presenciales, después de la emergencia sanitaria
Authors: Andraca Sánchez Ciro , González González Justiniano , Muñoz García Alejandra Hitahii , Mendoza Mojica Manuel , Bueno Domínguez Paulino
Published: November 2023

El objetivo del estudio fue identificar las variables asociadas en la transición de las clases virtuales a las presenciales, durante la primera semana del regreso a las aulas, después de la emergencia sanitaria por la COVID-19. En el estudio transversal, basado en el enfoque descriptivo-correlacional, se analizaron variables socioeconómicas, socioemocionales y actitudinales, en estudiantes de la preparatoria No. 9 de la Universidad Autónoma de Guerrero, México. Participaron 58 alumnos y 86 alumnas. Se utilizaron las pruebas de odds ratio (OR) y chi-cuadrado, a partir de la utilización del software SPSS 25, encontrándose, con mayor significancia, la baja escolaridad de los padres (p=,000), compartir celular durante las clases virtuales (p=,000), problemas económicos familiares (p=,000), deficiente señal de internet (p=,001), tener un trabajo remunerado (p=,002), el jefe de familia no tenía un salario fijo (p=,012), y vivir fuera de la ciudad sede de la escuela (p=,044). Con respecto al sexo, se analizó la diferenciación porcentual de las variables socioemocionales: malhumor, ansiedad, aburrimiento, intranquilidad, cansancio y tristeza. Asimismo, se realizó el análisis de varianza (ANOVA) sobre la actitud estudiantil (1. muy de acuerdo o de acuerdo; 2. ni de acuerdo, ni en desacuerdo, y 3. en desacuerdo y muy en desacuerdo) frente a los efectos de la pandemia, encontrándose variaciones entre los valores de los grupos 1 y 3, respecto a las opiniones: hombres y mujeres deben compartir responsabilidades; priorizar el apoyo a la mujer para seguir estudiando, y cuando un familiar se enferma, es preferible que sea cuidado por la mujer, situación similar a lo reportado por González y Cuenca (2020), donde las mujeres fueron más propensas a la realización de tareas del hogar. Se requieren nuevas investigaciones sobre resiliencia, después de haber regresado a las clases presenciales.
African American PhD Social Work Students’ Perspectives and Experiences on Qualitative Research Methods
Authors: Lee Eric P. , Henderson Chelsey , McDaniel Deidre , Maith Christopher , Miller David , Daughtery Laura
Published: November 2023

African American PhD students are severely underrepresented in the attainment of PhDs compared with their White counterparts and, therefore, underrepresented as PhD professors. Key factors contributing to the lack of African American students seeking doctoral education include financial hardship, racial discrimination, and a lack of mentorship. The purpose of this qualitative study is to investigate the experiences and meaning of African American social work students enrolled in a PhD qualitative research methods course at a Historically Black College and University (HBCU). Results from this study will shed light on Black scholars’ experiences in obtaining a doctoral education, identify challenges and barriers in completing a doctoral program, and contribute to ideas on how to increase the number of Black scholars in HBCU PhD.
Potential of Reduction Solid Waste from Office Building (Case Study: Gedung Polda Jambi)
Authors: Laura Winny , Galih Ira , Lovena Anri
Published: November 2023

Solid waste management in building can be managed with the waste management policy and waste management practice tools. It is contained in the concept of green building. The purpose of this study was to analyze the potential reduce of solid waste in office buildings which is managed by waste management policy and waste management practice tools, and provide scheme recommendations for solid waste management for office buildings the object of this study is Jambi Regional Police Office Building. The methodology was a survey method with solid waste sampling (SNI 19-3964-1994) in Building A, Building B, Canteen and Garden Area and Parking The sampling did for 8 days. Quantitative and quantitative parameters were obtained from the calculation of the generation and composition of solid waste, and also interviews. The results for the generation of solid waste on Jambi Regional Police Office Building: 40.40 kg/day or 0.027 kg/person.day (consist of 45% organic, 28% inorganic, 26% paper and B3 0.7% and others 0.3%). Recommendations scheme can be given for solid waste management in the form of the application of waste management practice tools are started from modification of the waste into separate, collection is done as often as possible, solid waste treatment is done composting and sales to waste banks. The potential for reducing solid waste if the waste management policy and practice tools are applied is 85.64% to 5.8 kg/day.
Utilization of Bendrat Wire fiber on the Mechanical Properties of Geopolymer Concrete
Authors: Sucahyo Septian Gusti , Nurtanto Dwi , Utami Nanin Meyfa
Published: November 2023

One of the problems in the construction field, especially concrete, is to reduce cracking due to the brittle nature of the concrete itself and increase the strength of the concrete. One of the ingredients to minimize cracks in concrete is the addition of fiber in the concrete mixture. Therefore, additional innovation is needed in the manufacture of concrete. So, this research was carried out by discussing the use of bendrat wire on the mechanical properties of geopolymer concrete. This study aims to determine the results of compressive strength, split tensile strength, and flexural strength with variations in the addition of 0%, 6%, 12%, and 18% were using a 2% superplasticizer with a concrete age of 28 days. The addition of bendrat wire from 0%, 6%, 12%, and 18% of the test results has increased. For compressive strength, respectively, 40.34 MP, 40.552 Mpa, 40.977 Mpa, and 41.189 MPa. For the splitting tensile strength result, which is 2.07 MPa;, 2.123 MPa, 2.176 MPa, and 2.229 MPa. For flexural strength, 4.05 Mpa, 4.09 Mpa, 4.16 Mpa, and 4.25 MPa.
Ankieta na temat Andrzeja Leppera i partii Samoobrona
Authors: Kuligowski Piotr , Leder Andrzej , Moll Łukasz , Okraska Remigiusz , Woś Rafał
Published: November 2023

Tekst zawiera pytania przygotowane przez redaktorów numeru i nadesłane przez zaproszonych autorów odpowiedzi. Ankieta dotyczy Andrzeja Leppera i polityki populizmu. Zapytano między innymi o to, dlaczego Lepper przegrał oraz jakie lekcje można wyciągnąć dzisiaj z jego sukcesów i upadków. Ankieta służy jako rodzaj interwencyjnego, publicystycznego dodatku do numeru tematycznego czasopisma.
Teoria składu klasowego i skład klasowy w polskiej branży budowlanej
Authors: Król Krzysztof
Published: November 2023

Niniejszy tekst został oparty na podstawie prezentacji wygłoszonej podczas I Zjazdu Młodych w Ruchu Pracowniczym organizowanego przez Ogólnopolski Związek Zawodowy Inicjatywa Pracownicza. Zjazd odbył się w dniach 15-17 sierpnia 2020 r. na skłocie Rozbrat. Prezentacja, podobnie jak poniższy tekst, składała się z trzech części. Pierwsza część koncentrowała się na omówieniu teorii składu klasowego oraz na historycznych warunkach powstawania jej założeń. Druga część dotyczyła historycznych przekształceń składu klasowego w gospodarce kapitalistycznej, z kolei trzecia część stosowała teorię składu klasowego do opisu współczesnych stosunków produkcji panujących w polskiej branży budowlanej.
Actitudes y prácticas saludables en una comunidad étnica sobre la prevención de la tuberculosis en Lima, Perú
Authors: Huamán Arias Lucero Aisha , Zevallos Reátegui , Jessica Natividad , Zevallos Reátegui Julia Raquel
Published: November 2023

Objetivo: Determinar la actitud y las prácticas saludables de una comunidad étnica shipibo-konibo sobre la prevención de la tuberculosis. Material y métodos: Investigación descriptiva, transversal. Participaron 96 mujeres de la comunidad shipibo-konibo, quienes viven en Lima y cuyos hijos estudian en una escuela intercultural bilingüe. Para evaluar las actitudes y las prácticas saludables, se elaboró un instrumento que consta de 29 preguntas, de las cuales, 9 son sociodemográficas, 10 miden actitud y 10 determinan las prácticas de prevención de tuberculosis. El instrumento obtuvo validez por prueba binomial (p ≤ 0.01) y confiabilidad por Kuder-Richardson (> 0.7). Se realizó un análisis descriptivo. Resultados: Las participantes se caracterizaron porque eran convivientes en 76.04% y madres solteras en 18.8 %. El 21.9 % tenía 3 hijos; el 77.09 % tuvo educación secundaria; el 47.92 % refirió tener un ingreso mensual inferior a 900 soles; el 80.21 % no posee acceso a agua y desagüe. De manera general, la comunidad étnica presentó actitud global favorable en 55.21 % sobre la prevención de tuberculosis; y en cuanto a las prácticas preventivas de tuberculosis evidenciaron ser no saludables en 64.58 %. Conclusiones: Se observó, de forma global, predominio de prácticas no saludables y de una actitud favorable para la prevención de la tuberculosis.
Factores profesionales y conocimiento de la comorbilidad tuberculosis-diabetes en responsables de salud de la Estrategia Sanitaria de Prevención y Control de Tuberculosis
Authors: Campos Coronel Hugo Rolando , Llanos Zavalaga Luis Fernando
Published: November 2023

Objetivo: Determinar la asociación entre los factores profesionales y el grado de conocimiento de la comorbilidad tuberculosis-diabetes (TB-DM) en profesionales de salud responsables de la Estrategia Sanitaria de Prevención y Control de Tuberculosis (ES-PCTB) de una red de salud de Lima. Metodología: Estudio cuantitativo observacional de tipo transversal analítico; se trabajó con el universo de centros de salud de la Red de Salud San Juan de Lurigancho. Se aplicó el cuestionario «Factores profesionales y conocimientos sobre la comorbilidad TB-DM en profesionales de la salud responsables de la ES-PCT», constituido por características sociodemográficas (3 preguntas), factores profesionales (3 preguntas), criterios para identificación de TB-DM (9 preguntas), diagnóstico de TB-DM (21 preguntas), y tratamiento TB-DM (20 preguntas); el cual fue validado por un grupo de expertos (p = 0.01) y prueba piloto con coeficiente Kuder-Richardson de 0.89. Resultados: El 50 % de los profesionales de la salud responsables de las ES-PCT son médicos generales, y el 50 % son enfermeros; el 88.2 % no realizaron estudios de postgrado y un 50 % llevaba tiempo trabajando en la ES-PCT, que oscila entre 1 a 5 años. La proporción de profesionales de la salud con conocimiento adecuado fue de 20.6 %. Se halló asociación entre el tipo de profesional de la salud y el conocimiento de la comorbilidad TB-DM (p = 0.001). Conclusiones: Se encontró asociación significativa entre el tipo de profesión de salud y el conocimiento de la comorbilidad TB-DM.
Cuidados de los padres de familia frente a las reacciones postvacunación de sus niños menores de un año en el servicio de inmunización de un centro de atención primaria
Authors: Huaman Hinostroza Maria Paula , Huangal Silva Melannie Alessandra , Victorio Roncal Emily Milagros , Torres Deza Clara Carmen
Published: November 2023

Objetivo: Determinar los cuidados brindados por los padres de familia frente a las reacciones postvacunación de sus niños menores de un año en el servicio de inmunización de un centro de salud materno infantil en Zapallal (Lima, Perú). Material y métodos: Estudio de enfoque cuantitativo, descriptivo y transversal. La muestra estuvo conformada por 60 participantes con niñas(os) menores de un año de edad, seleccionados por muestreo aleatorio simple. El instrumento fue elaborado por las investigadoras, el cual contiene 22 ítems y está compuesto por tres partes: i) datos sociodemográficos, ii) cuidado de los padres de familia frente a las reacciones locales, y iii) cuidado de los padres de familia frente a las reacciones sistémicas; asimismo, ha sido validado a través de juicio de expertos y prueba piloto mediante KR = 0,712, demostrando que el instrumento es confiable. Resultados: Los padres de familia se caracterizaron por ser de nivel secundario, estado civil conviviente, con dos hijos en promedio. De forma general, declararon brindar cuidado adecuado en un 58,33 % frente a las reacciones postvacunación. Al revisar los cuidados postvacunación, se encontró que fueron adecuados frente al dolor en 56,67 %, ante el endurecimiento en 20 %, y frente al enrojecimiento en 41,67 %. En cuanto a las reacciones sistémicas, fueron adecuados los cuidados ante la identificación de fiebre en 33,33%, ante la fiebre en 91,67%, frente a la diarrea en 60,00 %, en presencia de vómito en 85,00 %, ante la pérdida de apetito en 23,33 %, y frente a la irritabilidad en 51,67 %. Conclusiones: En la mayoría de padres de familia prevaleció los cuidados adecuados frente a las reacciones locales y sistémicas postvacunación.
Concept Analysis of the Sacred in Nursing Practice
Authors: Rader Beverley
Published: November 2023

The purpose of this concept analysis was to clarify the meaning of the sacred in nursing practice by applying Chinn and Kramer’s (2015) framework. Online word etymology published works of scholars and nurse theorists were the foundational sources for this concept analysis. Additionally, an extensive review of published nursing literature retrieved 42 records between the years 1987 and 2019. Three themes and seven subthemes were identified, which help to make meaning of this nursing concept. Major themes include encountering the sacred at the major life transitions, honoring the sacred during patient care, and acknowledging the sacred nature of the nursing practice.
The Association of Family Characteristics with Dietary Diversity among Adolescent Girls in Denpasar City, Bali, Indonesia
Authors: Utami Ni Wayan Arya , Ani Luh Seri
Published: November 2023

Background: The three main nutritional problems in adolescent girls are chronic energy deficiency, obesity, and anemia. These problems are associated with food quality or dietary diversity, often influenced by family characteristics.
Objectives: This study aimed to determine the association of dietary diversity among adolescent girls in Denpasar City with family characteristics, such as parents' occupation, education and income, type and size of family, government social programs, and food security.
Methods: This cross-sectional study was conducted involving 516 adolescent girls selected through a multistage sampling. The first stage involved the selection of 12 villages in 4 sub-districts, and the second involved using simple random sampling to select respondents from each village. Data were obtained using the Minimum Dietary Diversity for Women questionnaire, and Multiple logistic regression was applied to identify the determinant of dietary diversity.
Results: The result showed a mean score of 6.7 (SD±1.7) with a maximum of 8.4, and the proportion of inadequate dietary diversity was 11.4%. Based on a bivariable test, six variables were found to be significantly associated with dietary diversity among adolescent girls. After including these variables in a multiple logistic regression model, it was observed that family size (AOR=6.986; 95% CI: 2.718 -17.957; p-value=0.000), mother's education (AOR =1.904; 95% CI: 1.029-3.525; p-value=0.04), and household income (AOR=0.422; 95% CI: 0.227-0.784; p-value=0.006) were significantly associated with dietary diversity.
Conclusions: In conclusion, family characteristics, such as having a family size of five or more, a lower level of mother’s education, and household monthly income below the district minimum wage, were significantly associated with inadequate dietary diversity. This condition required intervention in the form of promoting food diversification at the family level.
The Effectiveness of Smartphone-Based Nutrition Education Intervention in Successful Practice of Exclusively Breastfeeding: A Meta-Analysis
Authors: Pratiwi Rachmahnia , Atmaka Dominikus Raditya , Sutoyo Deandra Ardya Regitasari , Mahmudiono Trias
Published: November 2023

Background: Exclusive breastfeeding is the cornerstone of infant health and one of the 2030 Sustainable Development Goals (SDGs). The advancement of information technology can be used to promote health, and providing information through messages on smartphone applications can improve breastfeeding awareness and adherence.
Objectives: To determine which social media platforms effectively promote exclusive breastfeeding through nutrition education interventions.
Methods: This study employed a meta-analysis method. The terms “breastfeeding,” “social media,” and “smartphone” were used to search for articles in multiple electronic journals, such as Scopus, PubMed, ScienceDirect, and Google Scholar. Articles that provide an intervention using smartphone media for groups of expectant mothers who wish to breastfeed their babies and mothers who have ceased breastfeeding and want to resume were selected. Forest plot analysis was performed using the STATA 12.
Results: From 2018 to 2021, seven articles were obtained, with research conducted in the United States, India, Indonesia, Israel, and Brazil. The study’s findings revealed that a nutritional education intervention using Smartphones led to an average success rate of exclusive breastfeeding between the intervention group and the control group of 1.23 (7 studies), 95% CI (1.08 - 1.39); P = 0.000; and I2 = 97.1%.
Conclusions: Intervention using smartphones by sending short messages daily and counselling by telephone every week can increase mothers’ knowledge and ability to provide exclusive breastfeeding to their infants. An intervention using smartphones to transmit daily text messages and weekly telephone counselling could enhance mothers’ knowledge and ability to breastfeed their children exclusively.
Integrate memory mechanism in multi-granularity deep framework for driver drowsiness detection
Authors: Zhang Handan , Liu Tie , Lyu Jie , Chen Dapeng , Yuan Zejian
Published: November 2023

Driver drowsiness detection is a critical task for early warning of safe driving, while existing spatial feature-based methods face the challenges of large variations of head pose. This paper proposes a novel approach to integrate the memory mechanism in a multi-granularity deep framework to detect driver drowsiness, and the temporal dependencies over sequential frames are well integrated with the spatial deep learning framework on the frontal faces. The proposed approach includes two steps. First, the spatial Multi-granularity Convolutional Neural Network is designed to utilize a group of parallel Convolutional Neural Network extractors on well-aligned facial patches of different granularities and extract facial representations effectively for large variations of head pose. Furthermore, it can flexibly fuse detailed appearance clues of the main parts and local-to-global spatial constraints. Second, the memory mechanism is set up using a deep long short-term memory network of facial representations to explore long-term relationships with variable length over sequential frames, which is capable of distinguishing the states with temporal dependencies, such as blinking and closing eyes. The proposed approach achieves 90.05% accuracy and about 37 frames per second (FPS) speed on the evaluation set of the National Tsing Hua University Driver Drowsiness Detection dataset, which is applied to the intelligent vehicle for driver drowsiness detection. A dataset named Forward Instant Driver Drowsiness Detection is also built and will be publicly accessible to speed up the study of driver drowsiness detection.
YEREL İDARELERDE KAMU PERSONELİNİN PERFORMANS YÖNETİMİNE YAKLAŞIMI: KOCAELİ BÜYÜKŞEHİR BELEDİYESİ ÖRNEĞİ
Authors: DEMİREL Demokaan , MİDİLLİ SORAN Melikenur
Published: November 2023

Kamu yönetimi vatandaş taleplerine duyarlı olmak, hizmet sunumunda niteliği artırmak durumundadır. Yerel yönetimler halka en yakın demokratik birimlerdir. Türkiye’de yerel yönetimlerin, özellikle de metropoliten belediyelerin sundukları hizmetin çeşitliliği ve hizmet sunulan alanın büyüklüğü dikkate alındığında maliyet-fayda analizi yapmaları elzemdir. Performans yönetim yerel ölçekteki hizmetlerin vatandaş taleplerine uygunluğunu değerlendirerek ekonomik rasyonalite mantığını kamu yönetiminde geçerli kılmaktadır. Performans yönetiminin başarılı biçimde uygulanabilmesi yerelde istihdam edilen kamu personelinin niteliğine de bağlıdır. Bu çalışma yerel kamu personelinin Kocaeli Büyükşehir Belediyesi örneğinde performans yönetimine yaklaşımı ortaya koyma amacındadır. Çalışma metodolojik olarak Kocaeli Büyükşehir Belediyesi’nde çalışan basit örnekleme yöntemiyle seçilen 350 memura uygulanmıştır. İstatistiki veriler tek yönlü ANOVA, tek yönlü regresyon, Pearson korelasyonu, standart sapma ve ortak frekans yöntemleriyle analiz edilmiştir. Ulaşılan sonuçlara göre, genel olarak yerel kamu personeli performans ölçüm uygulamalarına sıcak bakmaktadır. Bunun için uzman personel istihdamı ile değişim sürecini başlatacak hizmet içi eğitim programlarına ihtiyaç vardır. Performans değerlendirmelerinin çoğulcu bir perspektife dayandırılması, görevde yükselme, ücretlendirme, ödül ve disiplin uygulamalarında dikkate alınması gerekli görülmektedir. Yerel düzeydeki katılımcı ve demokratik uygulamaların performans sonuçlarına olumlu yansıyacağı düşünülmektedir.
ÇİFT MARKALI OTEL KAVRAMINA YÖNELİK TEORİK BİR DEĞERLENDİRME
Authors: DEMİRAY Gökhan , ÖZTÜRK Mertcan
Published: November 2023

Şirketler hem maliyetler açısından hem de pazarlama açısından çeşitli faydalar sağlayabilmek için marka ittifakı stratejileri uygulamaktadırlar. Uygulamalar kapsamında turizm sektöründe de çift marka stratejisi, maliyet ve operasyonel verimlilik sunduğu için sektörde ilgi görmekte ve gelişme gösteren yeni bir strateji olarak kabul edilmektedir. Çift markalı otel stratejisi, küresel otel şirketleri arasında yaygınlık kazanmaya başlamasına rağmen akademik alanda araştırmalar eksik kalmaktadır. Özellikle ulusal literatürde yeterince ele alınmaması sebebiyle çift markalı otel kavramının teorik altyapısının oluşturulması ve sonraki çalışmalara yol gösterici olabilmek adına teorik bir değerlendirme yapılması amaçlanmıştır. Çalışmada nitel araştırma yöntemi esas alınmış olup, konuya ilişkin kaynak ve doküman incelemesi gerçekleştirilmiştir. Çalışmanın amacı doğrultusunda kavramın gelişim süreci, uygulamadaki avantaj ve dezavantajları, sektörel örnekleri, tanımlamaları sunulmuş olup sonraki çalışmalara faydalı olabilecek önerilerde bulunulmuştur.
Attitude towards Sexuality: Perceptions of Male University Students in Gujarat
Authors: Thomas Bigi
Published: November 2023

At a time when there is an unprecedented surge in reported cases of all forms of sexual violence, including rape of women by men even within intimate relations across the world, it is essential to investigate men’s attitude towards sexuality with its intricacies from a gendered perspective, especially when the legal, social and cultural structures continue to fail in challenging the prevailing gendered discourses around sexuality. This study attempts to explore the attitude of male university students towards sexuality and encapsulate the same with gender-specific patriarchal theories. With a descriptive research design, this study interviewed 396 male university students from a chosen university in Gujarat, India, selected by stratified — systematic sampling method from different streams of study. Quantitative analysis underlined and clearly portrayed the unfavourable attitudes towards sexuality held by a large proportion of university students. This study also attempts to illustrate how gendered power inequality highly influences their sexual entitlement and sexual constriction attitudes.
El Sueño educativo de Plotino Rhodakanaty, en México
Authors: Marín Meneses Benjamín
Published: November 2023

En el presente escrito, el autor trata de exponer los intentos educativos, en México, del griego Plotino Constantino Rhodakanaty. Médico de profesión, y sumamente versado en el socialismo, arribó a las costas de Veracruz a inicios de febrero de 1861. Su llegada al país respondió a los decretos presidenciales de Ignacio Comonfort, quien esperaba llamar la atención de extranjeros, para que poblaran las regiones más abandonadas e inhóspitas de México. El heleno, fiel a las doctrinas que profesaba, se presentó al escenario político con varias propuestas de cambio social, siendo la educación uno de los vectores más importantes que intentó desarrollar. El objetivo es desglosar esa historia, para dar a conocer las bases del primer proyecto educativo de corte socialista en México. Se busca solventar un problema fundamental: Rhodakanaty no legó un plan de estudios que reflejara sus deseos concretos, pero sus manuscritos sí están llenos de comentarios educativos. Para reconstruir su sueño pedagógico se ocuparán escritos de la propia autoría de Rhodakanaty, añadiendo también referencias a los autores que le influyeron y notas periodísticas que constatan su proselitismo.
Una educación humanista desvinculada de la práctica docente
Authors: Alarcón Félix Carmen Patricia
Published: November 2023

El presente ensayo muestra los rasgos del enfoque humanista de la educación que presentan las reformas educativas generadas en México: 1993, 2006, 2011 y 2017, exponiendo la desvinculación que existe con las prácticas docentes actuales desde una visión de la maestra responsable del Departamento de Orientación Educativa del nivel de secundaria, con los propósitos, perfil de egreso y competencias para la vida que dejan muy en claro las características del tipo de ciudadanos que se pretenden formar en su paso por la educación básica. Del mismo modo, se mencionan los principales precursores del humanismo y sus aportaciones. Se habla de algunos rasgos de la educación tradicionalista con la intención de compararla con lo que ofrece el paradigma humanista de la educación y la necesidad que impera en nuestra sociedad de ver reflejados en sus integrantes los valores que permitan una interacción social positiva y enriquecedora para todos. Se expresa cómo dicha necesidad se puede atender de manera relevante si al interior de las aulas se trasladan los valores, principios y fundamentos de esta corriente pedagógica. Se proponen algunas estrategias para promover una comunicación asertiva a partir de la autoevaluación y coevaluación del trabajo de los docentes, directivos, alumnos y alumnas.
AUSTRIAN SYNDROME: A RARE CASE REPORT
Authors: HASSAN KAMENA MWANA-YILE , EJJEBLI Samia , BADI Hanane , BUCUMI Jean Claude , MARHOUM Kamal El Filali
Published: November 2023

Austrian syndrome is a rare and fatal triad of pneumonia, meningitis and endocarditis caused by Streptococcus pneumoniae, with a mortality rate of 60%. We report a case of Austrian syndrome in a 59-year-old patient, witha history of arterial hypertension on angiotensin 2 receptor antagonist therapy for five years, chronic smoking at 20 packs per year and occasional enolism for fifteen years, presenting with prolonged fever associated with loss of consciousness with no respiratory or cardiac signs, in whom purulent bacterial meningitis with positive Gram stain, infective endocarditis with mitral and aortic localization and interstitial pneumopathy have been demonstrated with negative blood cultures. Although the mortality rate is very high, early management of Austrian syndrome can improve the patient's quality of life.
Investigation of steam adsorption chillers to modernize existing central steam plant systems
Authors: Nallar Melisa , Barnett Shelia , Martinez-Guerra Edith , Potter Jamie , Rinaudo Christina
Published: November 2023

This report investigates the integration of steam adsorption chillers as a modernization strategy for conventional central steam plant systems. Our objective is to assess the feasibility, advantages, and challenges of incorporating steam adsorption chillers into existing steam plant setups to enhance energy efficiency and cooling capabilities. Central steam plant systems have historically been used for steam-based heating but often lack cooling capabilities, necessitating additional cooling infrastructure. Steam adsorption chillers offer a potential solution by using waste steam for cooling, optimizing energy utilization and reducing reliance on traditional cooling methods. Through a comprehensive analysis, this report evaluates the technical compatibility and potential cost implications of implementing steam adsorption chillers. It explores factors such as system integration, operational dynamics, and maintenance requirements to provide a holistic view of the feasibility and benefits of this modernization approach. The findings aim to offer valuable insights to decision-makers and Army facility managers seeking innovative ways to upgrade central steam plant systems. By considering the technical and economic aspects of adopting steam adsorption chillers, this report contributes to the knowledge base for sustainable and efficient energy utilization in central plant operations.
Micropore Structure Characteristics and Recoverability Evaluation of Typical Shale Oil Reservoirs
Authors: Yao Lanlan , Yang Zhengming , Li Haibo , Du Meng , Zhou Tiyao , Zhang Yapu , Huang Qianhui , Chen Xinliang , Wang Ning
Published: November 2023

In view of the weak research on the availability of typical shale oil reservoirs from the perspective of development, this study introduced a two-dimensional nuclear magnetic resonance (NMR) evaluation method on the basis of the previous one-dimensional NMR combined with centrifugal physical simulation experiments. Not only the production characteristics of typical shale oil reservoirs were studied but also the microscopic production laws of different occurrence states were studied. The results show that the pore distribution of Jilin shale is more concentrated than that of Qinghai shale. The oil of the two blocks mainly occurs in 0.01–10 ms pores, and the occurrence ratio of Jilin shale in the pores is higher, which is more than 90%. The oil production of the two blocks is mainly dominated by 0.01–10 ms pores, and the utilization efficiency contribution of these pores in Jilin shale is higher, accounting for about 80%. The utilization efficiency (UE) increases logarithmically with centrifugal force, and the growth rate of Jilin shale is greater than that of Qinghai shale. The proportion of free oil in Jilin block is less than that in Qinghai block. The shale oil in the two blocks is both at 15% final UE, and the UE of free oil in Jilin shale is about 9% and that of Qinghai shale is about 12%. The recoverability of Jilin shale is lower than that of Qinghai shale.
The Effect of Knowledge Brokering on Nurses' Empathy with Patients Receiving Cardiac Care: An Experimental Study
Authors: Galehdarifard Atefeh , Khademi Mojgan , Gholami Mohammad , Radfar Moloud , Ebrahimzadeh Farzad , Imani-Nasab Mohammad-Hasan
Published: November 2023

Background
Previous reports have suggested a relationship between empathetic behaviors and a reduction in cardiovascular events. However, evidence has also revealed a lack of empathy among nurses. Therefore, interventions are necessary to improve empathy among cardiac nurses.
Aim
To determine the effect of knowledge brokering on nurses' empathy with patients receiving cardiac care.
Methods
This is an experimental study conducted on a total of 100 cardiac nurses. Participants were assigned to two groups of control and intervention using stratified random allocation. In the intervention group, knowledge brokering was performed using Dobbin's seven-stage method. Data were collected using Empathy Construct Rating Scale (ECRS) With the overall score ranges from +252 to -252. Then, data were analyzed using SPSS version 21. The significance level was considered < .05.
Results
The mean empathy change score (MECS) ± standard deviation was 22.90 ± 50.93 in the intervention group (p = .003) and 7.10 ± 60.20 in the control group (p = .408). The MECS between the study groups was compared based on the baseline empathy score (BES) (<100, ≥100). This comparison revealed that in nurses with BES ≥100, the adjusted MECS in the intervention group was significantly higher than the control group (11.44 units versus -15.42 units).
Conclusion(s)
The findings indicate that the effectiveness of knowledge brokering depends on the BES of nurses. The utilization of this intervention can enhance empathetic behaviors in cardiac nurses with a BES ≥100. This empirical study contributes to a better understanding of knowledge brokering.
New record of larval-pupal endoparasitoid Exorista deligata parasitising Indian Tea looper Hyposidra talaca from India
Authors: Sharma Pooja V. , Das Tamal , Mukherjee Susmita , Pathan Ejaj K. , Rahman Azizur , Gathalkar Ganesh B.
Published: November 2023

This is the first record of Exorista deligata (Pandellé, 1896) (Diptera: Tachinidae) as a parasitoid of Hyposidra talaca (Walker, 1860) (Lepidoptera: Geometridae) from India. H. talaca is a major and new emerging defoliator of the Tea plant Camellia sinensis (L) Kuntze (Theaceae). It completes multiple generations per year without diapause on C. sinensis, resulting in heavy crop loss. The field-collected larvae/pupa of H. talaca were checked for parasitoid infestations and reared until either the host or parasitoid emerged. The parasitoid was identified as E. deligata with morphological characteristics and confirmed by the mitochondrial cytochrome oxidase subunit-I (COX-CO1) gene sequencing technique. The parasitoid is infrequent with unexplored parasitic biology. It parasitises the larva and completes its lifecycle inside the developing H. talaca by entirely devouring the host. The mean percent parasitisation caused by E. deligata studied herein was 25.4% (range 5.88%-57.69%). Based on its parasitisation ability, we suggest the species could be a potential biological control agent to address the damage mitigation caused by the tea looper pest, H. talaca.
Values of LncRNA SNHG14 in The Differential Diagnosis and Prognosis Evaluation of Acute Ischemic Stroke
Authors: Lu Hongxiang , Zhang Yuezhan
Published: November 2023

The long non-coding RNA (LncRNA) SNHG14 has been investigated for its potential in acute ischemic stroke (AIS) and transient ischemic attack (TIA) diagnosis. 32 healthy people, 85 patients with AIS, and 40 patients with TIA had their blood tested to determine SNHG14 mRNA transcript levels using quantitative real-time polymerase chain reaction. (qRT-PCR). A stroke's severity was measured using the Stroke Severity Scale developed by the National Institutes of Health. (NIHSS). After 30 days, individuals with AIS were evaluated for progress using a modified Rankin Scale. (mRS).There was no significant difference in SNHG14 LncRNA levels between TIA patients and Controls, despite the huge rise in AIS incidence. (p > 0.05). (all p 0.001). Compared to those who did well on the AIS test, those who performed poorly had substantially greater levels of SNHG14 LncRNA. (mRS 0–1 points). (mRS 0–2). LncRNA SNHG14 had an AUC of 0.714 (80%, 61.18%) when used to identify AIS in TIA patients, and a comparable finding was seen when predicting a poor 30-day prognosis of AIS (73%, 66.67%). There are also graphical representations of the findings. Improvements in NIHSS and mRS scores were associated with increases in SNHG14 LncRNA mRNA levels in individuals diagnosed with AIS. It is critical that we focus entirely on this decision. (all p 0.05).Analysis of the long non-coding RNA known as SNHG14 in the patient's blood can be used to diagnose AIS, rule out TIA, forecast the intensity of the disease, and evaluate the prognosis. You can accomplish everything on that list simultaneously.
The Distance to the Stars
Authors: Siebenmorgen Ralf , Chini Rolf
Published: November 2023

The vastness of a clear night sky evokes for most people curiosity about the distance to the stars. There are two primary methods for estimating stellar distances – parallax and luminosity. In this study, we present a new analysis revealing a noteworthy discrepancy between these two methods. Due to the accuracy of GAIA, parallaxes can directly be converted into distances. In contrast, luminosity distances require – apart from the determination of apparent and absolute brightness of a star – the reddening value that allows a correction for interstellar extinction. Using 47 stars with non-peculiar reddening curves from the high-quality sample1 we find here that the luminosity distance overestimates the parallactic distance for most (79%) of these stars. This puzzling discrepancy can only be removed when incorporating a new population of large dust grains – so-called dark dust – with our model2 that respects contemporary constraints of the interstellar dust3 and is updated to scope for the first time with the absolute reddening. The model provides a visual extinction which unifies the conflicting distances. Another far-reaching consequence of the flat absorption and scattering properties of dark dust is that it broadens the light curves4 of SNIa, which serve as a measure of the quantity of dark energy5.
Retifanlimab and the arginase inhibitor CB-1158 show low activity in microsatellite-stable colorectal cancer patient-derived organoids co-cultured with tumor-infiltrating lymphocytes
Authors: Bayo Cristina , Marin Silvia , Madurga Sergio , Lahoz Sara , Archilla Ivan , Bravo Raquel , Cuatrecasas Miriam , Gines Angels , Hernandez Claudia , de Lacy Borja , Oliveres Helena , Rojas Mariam , Tarrado-Castellarnau Mariam , Valverde Silvia , Mas Francesc , Camps Jordi , Postigo Antonio , Benítez-Ribas Daniel , Cascante Marta , Maurel Joan
Published: November 2023

Background
Cancer immunotherapies show low activity in metastatic microsatellite-stable (MSS) colorectal cancer (CCR) patients. Arginase 1 inhibitors have shown activity in pre-clinical models associated with PD-1 inhibitors.
Methods
We established a platform with co-cultures of metastatic MSS CCR patient-derived organoids (PDOs) and expanded autologous tumor-infiltrating lymphocytes to evaluate the efficacy of retifanlimab (PD-1 inhibitor), CB-1158 (arginase inhibitor), and their combination. CB-1158, retifanlimab, and CB-1158 + retifanlimab were tested using two PDOs representative of the IMMETCOLS IMC3 signature.
Results
Increased T-cell PDOs recognition was observed in co-cultures versus T cells alone. CB-1158, retifanlimab and CB- 1158 plus retifanlimab failed to increase T-cell PDOs recognition and T-cell cytotoxic effects. CB-1158 inhibited arginase, but the impaired synthesis of endogenous ornithine, through arginase, decreased ornithine release into the co-culture medium and increased glutamine, histidine, and putrescine consumption as compensation to guarantee ornithine and polyamines synthesis.
Conclusion
These results demonstrate the lack of meaningful activity of both monotherapy and combination therapy in PDO and autologous tumor-infiltrating lymphocyte preclinical models and suggest modest clinical activity in metastatic CCR MSS, at least in tumors meeting IMC3 metabolic characteristics.
Comparative transcriptional analysis identifies genes associated with the attenuation of Theileria parva infected cells after long-term in vitro culture
Authors: Heijden Elisabeth van der , Lefevre Lucas , Gossner Anton , Tzelos Thomas , Connelley Timothy , Hassan Musa
Published: November 2023

Autologous administration of attenuated Theileria parva-infected cells induces immunity to T. parva in cattle. The mechanism of attenuation, however, is largely unknown. Here, we used RNA sequencing of pathogenic and attenuated T. parva-infected T-cells to elucidate the transcriptional changes underpinning attenuation. We observed differential expression of several host genes, including TRAIL, PD-1, TGF-β and granzymes that are known to regulate inflammation and proliferation of infected cells. Importantly, many genes linked with the attenuation of the related T. annulata-infected cells were not dysregulated in this study. Furthermore, known T. parva antigens were not dysregulated in attenuated relative to pathogenic cells, indicating that attenuation is not due to enhanced immunogenicity. Overall this study suggests that attenuation is driven by a decrease in proliferation and restoration of the inflammatory profile of T. parva-infected cells. Additionally, it provides a foundation for future mechanistic studies of the attenuation phenotype in Theileria-infected cells.
Integrating brainstem and cortical functional architectures
Authors: Misic Bratislav , Hansen Justine , Cauzzo Simone , Singh Kavita , Garcia-Gomar Maria Guadalupe , Shine James , Bianciardi Marta
Published: November 2023

The brainstem is a fundamental component of the central nervous system yet it is typically excluded from in vivo human brain mapping efforts, precluding a complete understanding of how the brainstem influences cortical function. Here we use high-resolution 7 Tesla fMRI to derive a functional connectome encompassing cortex as well as 58 brainstem nuclei spanning the midbrain, pons and medulla. We identify a compact set of integrative hubs in the brainstem with widespread connectivity with cerebral cortex. Patterns of connectivity between brainstem and cerebral cortex manifest as multiple emergent phenomena including neurophysiological oscillatory rhythms, patterns of cognitive functional specialization, and the unimodal-transmodal functional hierarchy. This persistent alignment between cortical functional topographies and brainstem nuclei is shaped by the spatial arrangement of multiple neurotransmitter receptors and transporters. We replicate all findings using 3 Tesla data from the same participants. Collectively, we find that multiple organizational features of cortical activity can be traced back to the brainstem.
Heritable changes in chromatin contacts linked to transgenerational obesity
Authors: Blumberg Bruce , Chang Richard Cheng-An , Egusquiza Riann , Amato Angélica , Li Zhuorui , Joloya Erika , Wheeler Hailey , Nguyen Angela , Shioda Keiko , Odajima Junko , Lawrence Michael , Shioda Toshi
Published: November 2023

Burgeoning evidence demonstrates that effects of environmental exposures can be transmitted to subsequent generations through the germline without DNA mutations1,2. This phenomenon remains controversial because underlying mechanisms have not been identified. Therefore, understanding how effects of environmental exposures are transmitted to unexposed generations without DNA mutations is a fundamental unanswered question in biology. Here, we used an established murine model of male-specific transgenerational obesity to show that exposure to the obesogen tributyltin (TBT) elicited heritable changes in chromatin interactions (CIs) in primordial germ cells (PGCs). New CIs were formed within the Ide gene encoding Insulin Degrading Enzyme in the directly exposed PGCs, then stably maintained in PGCs of the subsequent (unexposed) two generations. Concomitantly, Ide mRNA expression was decreased in livers of male descendants from the exposed dams. These males were hyperinsulinemic and hyperglycemic, phenocopying Ide-deficient mice that are predisposed to adult-onset, diet-induced obesity. Creation of new CIs in PGCs, suppression of hepatic Ide mRNA, increased fat mass, hyperinsulinemia and hyperglycemia were male-specific. Our results provide a plausible molecular mechanism underlying transmission of the transgenerational predisposition to obesity caused by gestational exposure to an environmental obesogen. They also provide an entry point for future studies aimed at understanding how environmental exposures alter chromatin structure to influence physiology across multiple generations in mammals.
ASAP: an automatic sequential assignment program for congested multidimensional solid state NMR spectra
Authors: Chen Bo
Published: November 2023

Accurate signal assignments can be challenging for congested solid-state NMR (ssNMR) spectra. We describe an automatic sequential assignment program (ASAP) to partially overcome this challenge. ASAP takes three input files: the residue type assignments (RTAs) determined from the better-resolved NCACX spectrum, the full peak list of the NCOCX spectrum, and the protein sequence. It integrates our auto-residue type assignment strategy (ARTIST) with the Monte Carlo simulated annealing (MCSA) algorithm to overcome the hurdle for accurate signal assignments caused by incomplete side-chain resonances and spectral congestion. Combined, ASAP demonstrates robust performance and reduces the time of signal assignments of large proteins (> 200 residues) from years to days.
Laser-printed 3D full-thickness skin equivalent morphology and metabolism monitoring by dual-mode OCT/Fluorescence system
Authors: Sokolovski Sergei , Khalid Arooj , Dremin Viktor , El-Tamer Ayman , Surmina Maria , Lancelot Celine , Rafailov Edik
Published: November 2023

The 3D architecture of native human skin is a crucial requirement in investigating the skin in health and pathologies, wound healing, and testing of skin cosmetic and care product safety and personalized skin disease treatments. In this research, we used human skin cell lines to build full-thickness skin equivalents (FSE). Tissue regenerative medicine is based on tissue engineering and so far, FSE is well known approach to developing healthy and pathological skin models. Here we architected 3D printed high-resolution scaffolds for the growth and maturation of the FSEs also developed and validated custom-built combined fluorescence spectroscopy (FS) and optical coherence tomography (OCT) imaging system for indestructible assessing metabolism and morphology of developed human FSEs on 3D printed scaffolds. This system demonstrated high sensitivity in detecting fluorescence from nicotinamide adenine dinucleotide (NADH) and riboflavin 5’-adenosine diphosphate (FAD) in solutions and cell suspensions, and high-resolution imaging of FSE morphology. Thus, our developed multimodal optical system can be used in the future for the assessment of metabolism, maturation, and viability of 3D models of biological tissues in time-course development.