bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis and Evaluation of the Preliminary Stability of White Clays Containing Açaí (Euterpe oleracea) and Acerola (Malpighia emarginata) Powder for Topical use
Authors: Costa Carina Pinheiro , Maia Nicole Kananda Almeida , Pinheiro Emili Braga , Freitas Ana Carolina Gomes de Albuquerque de , Júnior José Otávio Carréra Silva , Alves Taís Vanessa Gabbay
Published: July 2023

Clays are used in cosmetology because they have moisturizing, rejuvenating and antioxidant properties. Such characteristics are enhanced with the combination of actives, such as açaí powder, rich in antioxidant activities, and acerola powder, which has B complex vitamins, but its highest concentration is vitamin C, thus, the two actives minimize damage against free radicals, promoting an improvement in the appearance of the skin. The formulations were developed at three different concentrations, where they were stored in polyethylene pots and underwent preliminary stability tests, where they were subjected to six cycles of thermal stress, since, at the end of each cycle, control parameters were analyzed quality, such as organoleptic characteristics, such as color, odor and appearance, to assess instabilities in formulations. Thus, pH and density values were also determined. In addition, during the ice-thaw process, the samples remained unchanged in terms of initial color, however, the aspects showed evidence of instability, that is, they showed slight changes, that is, the movements of the dispersed active particles to the edges of the pots. In addition, the pH values ranged from 5.0 to 5.5, since it is the appropriate pH value for the skin, as it resembles the stratum corneum, which has a pH of 5.5. In the same follow-up, the results referring to density, showed a high coefficient of variation, but during the statistical analyses, the formulations remained stable, that is, they are suitable for the next test steps.
PERAN KOPERASI BAITUL QIRADH BABURRAYYAN DALAM PEMBERDAYAAN PETANI KOPI GAYO DI DESA WIH NAREH KECAMATAN PEGASING KABUPATEN ACEH TENGAH
Authors: Kamari Samsul , Mahlil Mahlil , Fakhruddin Fakhruddin , Fatimah Fatimah
Published: July 2023

Abstract: The Gayo highlands are one of the coffee-producing regions in Indonesia and the fourth largest exporter of coffee beans in the world, so a good strategy and plan is needed to improve people's welfare through Gayo coffee commodities, one of which is through cooperatives such as the Qiradh Baburrayyan Cooperative for farmers who in Wih Nareh Village, Pegasing District. The purpose of this study was to find out the process of empowering Gayo coffee farmers that was carried out by KBQ Baburrayyan and the obstacles faced in empowering Gayo Coffee Farmers. This study uses a qualitative method with a descriptive approach. Data collection was carried out by interviews, observation, and documentation. The results of the research show that the role of KBQ Baburrayyan in empowering Gayo coffee farmers in Wih Nareh Village, Pegasing District, Central Aceh District has been going quite well. Wih Nareh Village so that the unemployment rate decreased. Then provide guidance to the community such as training and outreach. Furthermore, the Baitul Qiradh Baburrayyan Cooperative also provided seed assistance other than coffee because coffee has a harvest pause period to support the coffee farmers' economy.Keywords: The Role of Cooperatives; Empowerment; Coffee Farmers.Abstrak: Daratan tinggi Gayo merupakan salah satu daerah penghasil kopi di Indonesia dan pengekspor biji kopi terbesar keempat di dunia sehingga dibutuhkan strategi maupun rencana yang baik dalam meningkatkan kesejahteraan masyarakat melalui komoditas kopi gayo, salah satunya melalui koperasi seperti yang dilakukan pihak Koperasi Baitul Qirad Baburrayyan kepada para petani yang ada di Desa Wih Nareh Kecamatan Pegasing. Tujuan dari penelitian ini adalah untuk mengetahui proses pemberdayaan petani kopi gayo yang dilakukan KBQ Baburrayyan serta kendala yang dihadapi dalam melakukan pemberdayaan terhadap Petani Kopi Gayo. Penelitian ini menggunakan metode kualitatif dengan pendekatan deskriptif. Pengambilan data dilakukan dengan wawancara, observasi, dan dokumentasi. Hasil penelitian menunjukkan bahwa Peran KBQ Baburrayyan dalam pemberdayaan petani kopi Gayo di Desa Wih Nareh Kecamatan Pegasing Kabupaten Aceh Tengah telah berjalan cukup baik terlihat dari adanya beberapa program pemberdayaan yang saat ini sedang berlangsung yaitu dengan merangkul tenaga kerja dan anggota kelompok tani dari masyarakat yang ada di Desa Wih Nareh sehingga angka pengangguran menurun. Kemudian melakukan bimbingan kepada masyarakat seperti pelatihan dan sosialisasi. Selanjutnya pihak Koperasi Baitul Qiradh Baburrayyan juga memberi bantuan bibit selain kopi karena kopi memiliki masa jeda panen tujuannya agar menunjang perekonomian petani kopi tersebut.Kata Kunci: Peran Koperasi; Pemberdayaan; Petani Kopi.
The Role of Memorizing the Qur’an in Developing the Character of Students
Authors: Nurchayani Fitri , Rusdin Rusdin , Idhan Mohamad , Azma Azma
Published: July 2023

This article examines the role of Qur’an Memorization in shaping students' characters at Banua Qur’an Palu. This article aims to explore the factors that influence the ability to memorize the Qur’an and the extent to which Qur’anic memorization can shape students' personalities. The research adopts a qualitative method with a case study approach. Data is collected through direct observation, in-depth interviews, and written document analysis. Data analysis techniques include data reduction, presentation, verification, and conclusion. The research findings indicate that the factors influencing the ability to memorize the Qur’an include internal and external factors. Qur’anic memorization can shape the students' personalities because the Qur’an contains verses that prohibit wrongdoing and encourage righteous deeds. These findings align with Tomas Lickona's theory, which suggests that good character can be developed through the habituation of good deeds in students' daily lives. This habituation is known as Moral Knowing, Moral Loving (Moral Feeling), and Moral Doing (Learning to Do). The implications of this research highlight the importance of continuous learning and guidance from religious teachers in shaping the students' characters.
Integracja międzynarodowa Europy Środkowej w myśli politycznej obozu narodowego w czasie II wojny światowej
Authors: Miszewski Dariusz
Published: July 2023

W czasie II wojny światowej obóz narodowy propagował ideę imperialną i koncepcję bloków państw narodowych na czele z Polską. Jako imperium Polska mogła przeciwstawić się skutecznie imperializmowi Niemiec i ZSRR. Idea federacyjna rządu narażała Polskę na agresję ze strony sąsiednich mocarstw i utratę jej historycznych ziem na rzecz sąsiednich narodów. Była zagrożeniem dla państwa narodowego. Prowadziła do jego osłabienia przez struktury ponadnarodowe. Na historycznych ziemiach Polski mogło istnieć tylko państwo polskie. W Europie Środkowej miał powstać antyniemiecki blok państw narodowych pod jej kierownictwem. Współpraca z ZSRR była możliwa pod warunkiem poszanowania niezależności Polski i jej granic.
Utilizing pumice for enhanced structural lightweight concrete
Authors: Ramesh Kumar
Published: July 2023

The work studied the use of special concrete, specifically lightweight concrete, by incorporating pumice as a natural aggregate. One significant disadvantage of nominal concrete is its high dead load, or self-weight, which makes it economically inefficient as a structural material. In contrast, lightweight concrete, with its low density, offers advantages such as reduced dead loads and improved thermal insulation. This reduced density is achieved by partially replacing the coarse aggregate with pumice in the concrete mix. The investigation aimed to compare nominal concrete with lightweight concrete using grade M20. The lightweight concrete was created by replacing different proportions of the coarse aggregate with pumice, ranging from 0%, 20%, 40%, and 60%. The objective of the work was to determine the compressive strength and split tensile strength of the lightweight concrete. The results were then compared with those of conventional concrete to identify the optimal percentage of replacement that provides better strength and meets the structural recommendations. The work aimed to explore the benefits of using lightweight concrete with pumice as a replacement material, assess its strength characteristics, and determine the most favorable replacement percentage for achieving improved strength and meeting structural requirements.
Study of Bond Issuer Companies Listed on IDX and on PT Pefindo Rating List: The Effect of Financial and Non-Financial Factors on Bond Rating
Authors: Kusumowati Dewi , Tangpen Lebrina Lorince
Published: July 2023

The aim of this study is to determine the effect of liquidity, leverage, profitability, bond securities, and maturity variables on bond ratings of entities that issue bonds on the Indonesia Stock Exchange and PT Pefindo's rating list for the period 2019 - 2021. The objects used in this study are all bond issuer companies that have been recorded in PT Pefindo and have complete financial reports on the Indonesia Stock Exchange for 2019 - 2021. There are 11 bond issuer companies used as samples with 3 years of observation so that a sample of 33 is obtained. Sampling is determined by using a purposive sampling, while the insightful strategy utilized is calculated relapse examination. The result shows that liquidity (CR), leverage (DER), profitability (ROA), bond securities and maturity affect on the bond rating. This shows that liquidity, leverage, profitability, bond securities, and maturity have an impact on bond ratings for bond issuer’s entities.
Identifying the Factors Affecting MSMEs’ Intention to Buy Flavor B2 Replacer as Halal Seasoning Solution
Authors: Sulistyo Ricky Setiawan , Kurniawati Masmira
Published: July 2023

Consumption of halal food is currently not only a concern of the Muslim community, but non-Muslim communities have also paid attention to halal products due to their high health orientation. Lard oil is one of the ingredients to improve the taste of food; however, besides being haram, lard contains quite a complex fat content, so all people with health problems cannot consume it. Various breakthroughs have been made by innovating new products, such as the development of artificial flavors that can produce taste characteristics similar to lard but are healthy and halal to consume. This article examines the factors that influence the interest in using food and beverage providers to replace lard with B2 replacer products based on halal awareness, halal food knowledge and perceived value with attitude as a mediating variable. By taking a sample of 372 MSMEs food and beverage providers in the DKI Jakarta area using a purposive sampling technique, this study found that perceived value is the most powerful factor influencing purchase intention, followed by the halal awareness factor. However, halal food knowledge was found to have no direct effect on purchase intention.
Unbalance Response Analysis of a Rotor Kit with Two Identical Discs Located Between Bearings
Authors: Katinić Marko , Kolar Josip , Konjatić Pejo , Bošnjaković Mladen
Published: July 2023

In this paper, the dynamic behavior of a rotor kit with two identical disks located between the plain bearings was analyzed. Modal and harmonic analysis of this rotor kit configuration were performed in the Ansys software package. To calibrate the bearing parameters (stiffness and damping) in the numerical model, experimental measurements of the rotor kit with a disc mounted at the midspan of the shaft were performed. As a result of modal analysis, natural frequencies and models were obtained. Using the Campbell’s diagram, the critical speeds and the influence of the gyroscopic effects on the natural frequencies were determined. The responses of the rotor kit to different unbalance distributions were considered by harmonic analysis.
PQCDSM-Logic in Maintenance (TPM) and Mountaineering
Authors: Schmidt Stefan , S. G. Schmidt Benjamin
Published: July 2023

TPM is the foundation for JIT (Just in Time) and Lean Manufacturing and forms the basis of JIT or on-time delivery. The goal of TPM is to improve equipment effectiveness and optimize equipment performance, namely PQCDSM (Productivity, Quality, Cost and Delivery, Safety and health, environment, and Morale). Many producers have tried to transform their production system to a JIT or Lean production system with the aim of increasing productivity and quality, but thus far with little success. This contribution shows how trekking and climbing tours can be used to illustrate the application of PQCDSM-Logic in mountaineering and how this can be transferred to logistics and maintenance practice. The background is the author's decades of experience with expeditions, trekking and climbing tours, TPM implementations and interviews with numerous experts. There are many similarities between the application of PQCDSM-Logic in mountaineering and in logistics and maintenance practice, which will help both in operational practice in industry and in high mountain tours, especially regarding safety in a changing environment. Presented is the extrapolation from mountain climbing to TPM and the importance of leadership for a successful (summit climbs and the like) transformation of the production system to a JIT or Lean production system.
Attributions of Controllability and Helping Intentions among Students
Authors: Kramarić Mate , Kamenov Željka
Published: July 2023

Previous studies have shown that individual and social factors can moderate the relationship between attributions of controllability, emotions, and helping. The aim of this study was to test the attribution-emotion-helping relationship in the Croatian academic context and to investigate the moderating effects of some student variables, i.e., the helper’s academic field, personal absence from class, and the habit of taking notes in class. We conducted a survey experiment with vignettes describing a student who wants to borrow lecture notes. Participants also estimated how often they take lecture notes and how often they had skipped class in the previous semester. The data were collected from 298 students from three faculties of the University of Zagreb. Although Croatian students generally showed a high willingness to help a classmate in need and the effect of controllability on helping intentions was weak, the results supported the attribution-emotion model. However, the results suggest that some student characteristics may attenuate the relationship between controllability, emotions, and helping. The indirect effect of controllability on helping intentions through sympathy was weaker for participants who frequently skipped classes and rarely had their own lecture notes.
Aborting a deformed fetus, a comparative study in Islamic Jurisprudence and man-made laws
Authors: حسين فارس محمد
Published: July 2023

The development of science has led to the advancement of means of detecting the condition of the fetus while it is in its mother’s womb, and in some cases it is proven to the doctor that the fetus has a congenital defect and malformations, and that it will be born deformed and if it is born and lived it will be a burden on its parents, family and society in general, in addition to the pain he suffers Pains throughout his life. This resulted in a discrepancy in both Islamic jurisprudence, As well as positive laws when it comes to a fetus may be born deformed.
An Impact Case Study of Improved Road Infrastructure on Urban Communities in Samoa
Authors: Taua’a Susana
Published: July 2023

This study explores the social-economic impacts of the upgraded Vaitele Street on a selected number of households residing along a two-hundred-meter stretch of the Vaitele Street. Studies conducted elsewhere in the developed and developing world, report a significant positive impact of infrastructure on economic growth, income and productivity. Massive donor funded infrastructure investment particularly in major road and drainage construction have been implemented in Samoa for the last fifteen years to support development efforts to achieve the Millennium Development Goals, now replaced by Sustainable Development Goals. However, there has been a dearth of impact studies both at the national and local levels to gauge how road upgrades among other infrastructure developments are impacting the lives of the general population. This study intends to fill this knowledge gap, by documenting the social –economic experiences of twelve households with road frontage properties and how they are making the most of the opportunities presented by the upgraded Vaitele Street.
The Development of Trade Arrangements in the Caribbean Island Nations and the Pacific Island Countries
Authors: Rai Khushbu
Published: July 2023

The contemporary turn of events post-Brexit and the election of Donald Trump hints at a return of protectionism. However, for years now, the World Trade Organization (WTO) has been advocating and continues to advocate that regional arrangements and closer economic integration would benefit all countries. Arguments regarding trade integration clearly have been contentious. Nonetheless, in regards to small island countries (SICs), it is quite evident that they perform better together than alone. The route to regionalism has been a long and painful journey for both the Caribbean Basin and the Pacific Rim. Many simply dismiss the sluggish growth of the Pacific Island Countries (PICs) in comparison with the Caribbean Island Nations (CINs) by simply declaring that regionalism is working better for the latter. This study presents a detailed account of efforts at nurturing regionalism on the part of these two seemingly similar, yet distinguishable groups of islands. Through such scrutiny, this paper documents a stark contrast in the development of trade arrangements that clearly influence the growth of the regions.
Multilingualism & Translanguaging: A Review of Translanguaging Practices in the Linguistically Diverse Indonesian EFL Classrooms
Authors: Sutrisno Dwi Budidarma
Published: July 2023

This paper reviews the past decade of studies related to translanguaging practices on EFL learning context in Indonesia. This topic has crucially been discussed among scholars in educational settings due to the influence of multilingualism possessed by Indonesian EFL learners. The studies from 2010s-2020s are selected and critically reviewed by focusing on students‘ and teachers‘ perception of translanguaging practices used in EFL classrooms. The discussion covers meaningful insights from various education levels in Indonesia since the country is known as one of the most linguistically diverse communities. The analysis of the review shows how translanguaging contributes to helping the learning activities to be more comprehensive as well as develop students’ multilingual and linguistics competencies. Furthermore, it also lays out the use of code-mixing and code-switching are considered fundamental to balance the incorporation of three languages used while providing learning instructions and strategies. Finally, the pedagogical implication of translanguaging in a multilingual context is discussed. This paper hopes to encourage teachers to gain a deeper understanding of the language policies in the classroom and accommodate language development.
RHINOFACIAL CONIDIOBOLOMYCOSIS IN A DIABETIC MALE
Authors: Pal Dipankar , Chirag Ghale Ben
Published: July 2023

Fungal sinusitis may be caused by lamentous fungi like mucorales, aspergillus, entomophthorales. Mucormycosis, Aspergillosis have
immunocompromising risk factors whereas entomophthorales can occur in apparently healthy person with signicant soil exposure. It is a rare
condition with involvement of mucosa of the nasal sinuses and facial soft tissues. There is no bony or angioinvasion seen with these fungi. It grows
relentlesslessly and may mimic soft tissue neoplasm causing facial disgurement.
OBSERVATIONAL STUDY OF SEROPREVALENCE OF HUMAN PAPILLOMA VIRUS (HPV) BY ELISA METHOD IN FEMALE PATIENTS ATTENDING IN GYNAECOLOGY OPD
Authors: Haldar Jaydeb , Turbadkar Dilip , Baveja Sujata , Shubhra Das Shanta
Published: July 2023

Background: Human papilloma virus (HPV) infection has been reported to be frequently occurring sexually transmitted disease. Although most HPV infections regress, persistent HPV infection, however is strongly associated with the risk of cervical cancer and genital warts. Present study was an observational study of seroprevalence of Human Papilloma Virus (HPV) by ELISA method in female patients attending in Gynaecology OPD. Material and Methods: Present study was cross-sectional study, observational study, conducted in female patients attending Gynecology OPD with clinically suspected cases of HPV. Each patient underwent ELISA Test for HPV. Results: Among 160 patients, majority of were from age group 31-40 years (39.38%), having education of secondary schooling (38.13%), were ofce workers (32.5%) followed by house-wife 25.63%. The majority of patients were in Class III (38.75%) followed by Class IV (25.62%) Seroprevalence among patients was 23.12%. The patients who used homemade napkins had a highest seroprevalence of HPV 68.18% followed by patients who are suffering from STD's (63.83 %), had a family history of cervical cancer (50 %), women who used to smoke (37.7 %), drink (25 %), had multiple sex partners (25 %) and the least number seropositivity was among patient who had gynecological problems 23.12%. Conclusion: The association of demographic prole and seropositivity of HPV among patients showed that educational status, age of marriage, mode of contraception, parity, socioeconomic status, risk factors and clinical symptoms showed statistically signicant
PENGEMBANGAN MEDIA KOTAK PINTER AKSARA JAWA (PIRAWA) PADA MATA PELAJARAN BAHASA JAWA KELAS IV SD NEGERI GONDANG 03 KABUPATEN BATANG
Authors: Afiana Sinta Dina , Azizah Mira , Eka Subekti Ervina
Published: July 2023

The problem was found that the learning media was limited, the learning method was only lectures and assignments, the teacher had not used creative learning media which resulted in students not being enthusiastic and students' learning motivation low. The purposes of this research are 1) Knowing the procedure for developing Pirawa Box media, 2) Knowing the feasibility level of Pirawa Box media, 3) Knowing the practicality of Pirawa Box media. This study uses the Research and Development (RnD) method. Data collection techniques using interviews and questionnaires. Data were analyzed using qualitative descriptive and quantitative descriptive. The results showed that the Kotak Pirawa media was declared feasible with the analysis results from the media expert validation of 100% and the results of the material expert validation analysis of 95.7% very good category. The Pirawa Box media was stated to be practical with a percentage of 100% in the very good category. Through the results of the student response questionnaire analysis obtained a percentage of 99%. Based on the results of this study, the Pirawa Box media developed was declared feasible and practical to use in the learning process.
Mediation as an alternative method of resolving disputes in the opposition procedure against the trade mark application.
Authors: Radziwiłł Filip
Published: July 2023

Alternative dispute resolution (ADR) is becoming increasingly popular as a fast, effective, relatively cheap and lightly burdensome way to resolve conflicts. The aim of this article is to discuss the institution of mediation as an alternative method for resolving conflicts and the possibility of applying it in trade mark disputes, using the example of opposition to a trade mark application before the Polish Patent Office. The article divides the grounds for opposition into infringement of the personal or economic rights of third parties and identity with or similarity to an earlier trade mark, reputed trade mark or well-known trade mark. It analyses the possibility of using mediation at the stage which the legislature indicates to the parties as the time limit for amicable settling disputes as well as the legitimacy, possibility and admissibility of mediation at other stages of opposition proceedings.
Eine Frage des Preises
Authors: Nissen Madeleine
Published: July 2023

Der Preisdruck auf Bio steigt. Nun bündeln Öko-Bauern und Hersteller ihre Kräfte, um Druck bei der Politik zu machen. Ihnen geht es nicht nur ums Geld, sondern auch um den Standard. Madeleine Nissen
Asien-Sortiment wird breiter
Authors: Bender Ralf
Published: July 2023

Das Verständnis für asiatische Lebensmittel in Europa wächst. Gleichwohl sucht der Verbraucher nach Produkten, die gut verständlich und einfach in der Zubereitung sind.
Impulso de los planes y los fondos de pensiones de empleo por la ley 12/2022
Authors: Tapia Hermida Alberto J.
Published: July 2023

Este estudio expone el proceso de impulso de los planes y fondos de pensiones de empleo en España mediante la Ley 12/2022 que modifica la Ley de Regulación de los Planes y Fondos de Pensiones de 2002 para introducir dos nuevos instrumentos: los fondos de pensiones de empleo de promoción pública abiertos y los planes de pensiones de empleo simplificados.
Rezension von: Rothenhäusler, Gisela, Das Wurzacher Schloss 1940-1945
Authors: Schober Sarah-Maria , Rothenhäusler Gisela
Published: July 2023

Gisela Rothenhäusler: Das Wurzacher Schloss 1940-1945 – ein kleines Kapitel europäischer Geschichte. Kriegsgefangene im Oflag VC. Zivilinternierte aus Jersey. Jüdische Häftlinge aus Bergen-Belsen. Hg. von der Stadt Bad Wurzach. (Bad Wurzacher Reihe 1). Lindenberg: Kunstverlag Josef Fink 2008; 384 S., zahl. Abb., 24,90 EUR
أصول كتابة البحوث العلمية
Authors: سراج وليد محمد
Published: July 2023

هذا بحث في أصول وقواعد كتابة البحوث العلمية الزراعية باللغة العربية. وهو يبحث في طرائق ومناهج البحث العلمي والتأليفي، التي يمكن أن تعم أيضا على مجموعة العلوم الأخرى، التي تعتمد على المنهج التجريبي كعلوم الحياة، (البيولوجيا) والكيمياء والفيزياء والرياضيات وغيرها.
Lactobacillus plantarum: A Potential Health Booster- A Comprehensive Review
Authors: S Dr. Narendra Kumar
Published: July 2023

Lactobacillus plantarum has potential applications and health benefits. This comprehensive literature review highlights the probiotic properties of L. plantarum and its ability to withstand adverse conditions and adhere to the intestinal epithelium. It has immense applications in the food industry, focusing on fermentation, preservation, and bioactive compound production. Furthermore, the impact of L. plantarum on human health, including its role in modulating gut microbiota, enhancing immune responses, and potentially preventing gastrointestinal disorders are indicated. This literature review suggests its therapeutic potential in allergy, asthma, autoimmune disorders, and cancer. This research emphasizes L. plantarum's potential as a versatile probiotic strain with significant health implications. Keywords Lactobacillus plantarum, Beneficial probiotic, Gastrointestinal disorders, Immune system regulation, Pharmaceutical, Biotechnological industries, Biofuels, Bioplastics, Bioactive compounds, Gut microbiota, Metabolic Capabilities, Functional Properties.
Pyrrolizidine plant extracts as diagnostic biochemical markers on therapeutic consequences
Authors: Suranjana Haldar  , Atish Haldar
Published: July 2023

The consumption of cereals and bakery products contaminated with seeds of species containing Pyrrolizidine alkaloids (PAs) has been involved in mass poisonings in rural areas of Afghanistan, India, South Africa and the former USSR. Poisoning can manifest as acute or subacute veno-occlusive disease with specific symptoms such as persistent hepatomegaly, leading to cirrhosis or shown to have genotoxic, mutagenic, teratogenic and carcinogenic effects. Several such toxicity testing of PAs have been done in cultured animal cells with reference to mice model, to better understand the pathway of metabolic impairement. Also the pluripotent proprty of mice bone marrow cells show better analyzing capacity of differentiated cell lineages. Therefore this pre-analytic review aims to focus the risk evaluation methods of PA exposure on current knowledge and recent advances of metabolic pathways of different PAs. In addition, this review provides perspectives of precision toxicity assessment strategies and biomarker development for the risk control of human intoxication by PAs with eventual categorization of pyrrole-protein adducts like serum Alanine Transferase (ALT), Glutathione transferase (GSH-T), Alkaline Phosphatase (ALP) in different cell lineages grown by lab-based cell culture techniques.
Does the Sierra Madre Mountain Range in Luzon Act as a Barrier to Typhoons?
Authors: Bagtasa Gerry , Racoma Bernard Alan
Published: July 2023

Tropical cyclones (TCs) making landfall in Luzon weaken due to the surface friction of Luzon’s mountainous terrain and the reduced ocean heat, momentum, and moisture fluxes over the landmass. Landmass also influences TC rain distribution by orographic enhancement or blocking of a TC’s moisture-laden circulation. In this study, we investigated the influence of the effects of the Sierra Madre and the Cordillera Mountains Ranges (SMMR and CMR) on TC-associated wind and rainfall hazards to answer the question of whether the SMMR or the CMR mitigates TC hazards. We used the Weather Research and Forecasting (WRF) model with modified SMMR and CMR terrains to disentangle the effects of the orography with flat land. Results show that Luzon-passing TCs maintain their intensities at landfall regardless of the frictional effects of the mountain ranges but the CMR inhibits the re-intensification of westward-moving TCs emerging from landmass after traversing Luzon. The SMMR reduces wind exposure and basin-wide rainfall of the Cagayan Valley. Hence, the SMMR can be considered a barrier for that region. In addition, the weakening effect of the SMMR reduces the wind exposure of the island of Catanduanes and eastern Bicol the most. However, for the rest of Luzon, the SMMR enhances rainfall which will likely compensate for the slight decrease in wind exposure – especially considering that most TC-related damages are water/rainfall related. The CMR, overall, has a larger hazard-mitigating effect than the SMMR. In any case, we believe that shifting the discourse to these mountains’ biodiversity conservation and restoration – rather than their purported TC mitigating effects – will be more strategically constructive.
Development and Evaluation of Multi-week Tropical Cyclone Strike Probability Forecasts in the Philippines
Authors: Adelino Joanne Mae , Tierra Maria Czarina , Villafuerte Marcelino
Published: July 2023

Tropical cyclone (TC) forecast, provided a few weeks in advance, can be beneficial for the preparation and mitigation of disaster risks in TC-vulnerable countries such as the Philippines. In this study, TC strike probability forecasts with a lead time of up to 4 wk were derived by combining the TC tracks from each ensemble member of the three models – namely, NCEP Coupled Forecast System version 2 (CFSv2), European Centre for Medium-Range Weather Forecasts Ensemble Prediction System (ECMWF), and NCEP Global Ensemble Forecast System version 12 (GEFSv12) – to show how likely it is for a TC to form or strike an area within the 300-km radius of the TC center. To assess its performance, real-time-derived TC strike probability forecasts over the Tropical Cyclone Information Domain (TCID) of the Philippines (bounded by 0–27 °N and 110–155 °E) covering the period from 06 Oct 2020–31 Oct 2022 were evaluated. Verification metrics revealed that the skill and reliability of the TC forecasts vary with lead time and the TC being forecasted. Week 1 forecasts are reliable and can be helpful for decision-making, whereas Week 2 forecasts are considered most reliable only up to the 51–60% probability interval. On the other hand, forecasts with 3–4-wk lead times are reliable for probabilities less than 20%. The case study performed using five TCs with different intensity classifications has shown that generally, forecasts for TCs with stronger intensity have higher skill than forecasts for relatively weaker ones. It was also observed that the magnitude of the probability values varies with the intensity changes within the validity period. These findings suggest that multi-model ensemble forecasts can be utilized for the improvement and eventual operationalization of multi-week TC strike probability forecasts over the Philippines.
Pengaruh Kebijakan Politik Etis Terhadap Perkembangan Pendidikan di Indonesia
Authors: Novriyanto Yus , Apriyana Shelita Bunga , Komariyah Siti
Published: July 2023

Pendidikan merupakan program untuk meningkatkan kualitas sumber daya manusia dan mengurangi jumlah buta huruf yang berdampak baik kepada pemerintah Belanda dan rakyat pribumi. Pada masa kolonial Belanda Pendidikan formal sangat susah untuk masyarakat pribumi baik kaum priyayi maupun masyarakat biasa. Setelah menerapkan politik etis pada awal abad 20 dan lambat laun semakin banyak sekolah formal yang didirikan di Hindia Belanda, dampak dari kebijakan etis ini adalah melahirkan para intelektual yang akhirnya akan menyadari bahwa bangsanya sedang dalam kebebasan dan menginginkan perubahan. Rumusan masalah yang diangkat adalah bagaimana awal kebijakan politik etis, bagaimana sistem pendidikan masa kolonial, bagaimana lembaga pendidikan masa kolonial. Dari rumusan masalah yang diangkat, tujuannya adalah untuk mengetahui bagaimana awal kebijakan politik etis, bagaimana sistem Pendidikan masa kolonial dan mengetahui Lembaga Pendidikan pada masa kolonial. Dalam penulisan artikel ini penulis menggunakan metode penelitian adalah metode kualitatif dengan menggunakan sumber sekunder seperti buku dan jurnal ilmiah.

Kata Kunci: Pendidikan, Politik Etis, Kolonial
Decreto Ley 19990 y la remuneración asegurable de los servidores públicos del ministerio de cultura bajo el decreto legislativo 276 en Lima durante el año 2020
Authors:   , Núñez Argumedo Mercedes Virginia
Published: July 2023

La presente investigación, se ha desarrollado teniendo en cuenta que la participación del Estado Peruano en temas previsionales se gestiona a través del Sistema Nacional de Pensiones de la Seguridad Social (SNP) el cual ha sido creado mediante el Decreto Ley Nº 19990, siendo el otorgamiento de la pensión de jubilación la más relevante; y en ese sentido, sobre la base del planteamiento del problema de qué manera se relaciona la Pensión de Jubilación del Decreto Ley 19990 y la Remuneración Asegurable de los Servidores Públicos del Decreto Legislativo 276 del Ministerio de Cultura - Sede Lima 2020. Asimismo, el análisis descriptivo dentro del marco normativo nacional e internacional que guardan estrecha vinculación con el Sistema Nacional de Pensiones de la Seguridad Social en el Perú, se establecen los objetivos de esta investigación que analiza cómo se relaciona la Pensión Jubilación del Decreto Ley 19990 y la Remuneración Asegurable de los Servidores Públicos- Decreto Legislativo 276 del Ministerio de Cultura-Sede Lima 2020, así como inciden los montos insuficientes en los derechos fundamentales, los recursos humanos del sector público y el ciclo de vida laboral. Por otro lado, se abordan los principales aspectos de la problemática y una revisión de las últimas medidas dictadas por el Ejecutivo, sobre la Pensión Jubilación del Decreto Ley 19990- ONP y la Remuneración Asegurable de los Servidores Públicos. Finalmente, se presentan las conclusiones y recomendaciones, mediante las cuales se evidencia la necesidad de una reforma pensionaria, la aplicación de nuevas alternativas y mecanismos, para el incremento de los montos insuficientes de la Pensión de Jubilación, así como la mejora de la Remuneración Asegurable.
PENGARUH PENGEMBANGAN SUMBER DAYA MANUSIA DAN MOTIVASI KERJA TERHADAP KINERJA KARYAWAN PT FUMIDA JAKARTA
Authors: Nuryadi  , Ummi Kultsum
Published: July 2023

Tujuan dari penelitian ini adalah untuk mengetahui Pengaruh Pengembangan Sumber Daya Manusia Dan Motivasi Kerja Terhadap Kinerja Karyawan PT Fumida

Metode penelitian yang digunakan dalam penelitian ini adalah deskriptif dengan pendekatan kuantitatif. Populasi sebanyak 47 orang. Teknik pengambilan sampel dengan menggunakan sampel jenuh sehingga didapat jumlah sampel dalam penelitian ini sebanyak 47 responden. Teknik analisis data menggunakan regresi berganda.

Hasil penelitian menunjukan bahwa : (1) Terdapat pengaruh yang positif dan signifikan variabel pengembangan sumber daya manusia terhadap kinerja karyawan PT Fumida. Hal ini dibuktikan dengan nilai thitung > ttabel yaitu 7.704 > 2.015 dengan nilai probabilitas (signifikansi) = 0.000 yaitu berada di bawah 0.05. (2) Terdapat pengaruh yang positif dan signifikan variabel motivasi kerja terhadap kinerja karyawan PT Fumida. Hal ini dibuktikan dengan nilai thitung > ttabel yaitu 4.601 > 2.015 dengan nilai probabilitas (signifikansi) = 0.000 yaitu berada di bawah 0.05. (3) Terdapat pengaruh yang positif dan signifikan variabel pengembangan sumber daya manusia dan motivasi kerja terhadap kinerja karyawan PT Fumida Hal ini dibuktikan dengan nilai Fhitung>Ftabel  yaitu 30.831 > 3.21.

 

 

Kata kunci: Pengembangan sumber daya manusia, motivasi kerja, dan kinerja.
Method to choose the ideal size of earplug
Authors: Zimpfer Veronique , Andeol Guillaume , Demumieux Yvan , Job Agnes , Hamery Pascal , Blanck Geoffroy , De Mezzo Sebastien
Published: July 2023

The last version of 3MTM Combat ArmsTM earplugs was designed to meet the hearing protection needs of the French armed forces. This earplug uses triple-flange-design fits in three sizes (small, medium, and large) allowing the best adaptation to all morphologies. The individual choice of the size of the earplug is the major problem to have an adequate protection: how to choose the ideal size? Three methods were assessed in the current study. The first method was based on the observation of tympanometry tips fit. The second was a commercial device allowing to check the attenuation of the earplug in situ. The last one was based on the detection of leak in low frequency with an instrumented earplug. The objective of this study was to compare these three different methods. An assessment test with 106 soldiers was performed. Each soldier was tested with the three methods, in a different order. The results of the different methods are presented and compared.
Przekład w kontekście pomocy prawnej w sprawach karnych pomiędzy Polską a Turcją
Authors: Kologlu Małgorzata
Published: July 2023

Niniejszy artykuł ma celu przedstawienie najlepszego modelu tłumaczenia dla terminów ekwiwalentnych pomiędzy tureckim a polskim na podstawie przykładów zaczerpniętych z pism sądowych wymienianych w ramach współpracy sądowej pomiędzy oboma państwami. Teksty te zostały wybrane jako materiał badawczy, ponieważ obejmują szeroki zakres słownictwa nie tylko ustawowego, ale również specjalistycznego z zakresu postępowania karnego, a także języka potocznego zawartego chociażby w zeznaniach świadków. Autorka stara się przybliżyć główne problemy przekładowe tłumaczeń sądowych pomiędzy tureckim i polskim, przy okazji omawiając w skrócie status biegłego tłumacza przysięgłego w Turcji i związany z nim największy problem, z jakim boryka się Turcja w ramach współpracy sądowej z Polską, mianowicie brak wykfalifikowanych tłumaczy sądowych.
Heterocyclic Steroids
Authors: Mudgal Mukesh M. , Mudgal Mangesh M.
Published: July 2023

Steroids are organic compounds with four rings arranged in a precise
molecular configuration and are involved in many biological functions displaying a
wide spectrum of biological activities and diverse chemical reactivities. Structural
modifications of the steroidal rings have attracted a considerable amount of attention
recently. Steroids of natural origin have been modified in several ways, particularly in
the cyclopentanophenanthrene ring system with heteroatoms such as nitrogen, oxygen,
and/or sulfur or with the heterocyclic ring to obtain more active compounds with less
or no harmful side effects and are termed as heterosteroids or heterocyclic steroids.
Heterocyclic steroids are enticing as the minor modifications to the steroidal molecules,
produce remarkable differences in their biological activities. The introduction of the
heteroatom in the skeleton of a steroidal molecule often poses challenges to organic
chemists, demanding the exploration of new synthetic reactions and new synthetic
routes. In this article, the overview of the various synthetic strategies employed to
synthesize azasteroids, oxasteroids, thiasteroids, and steroids modified by the
introduction of the heterocyclic ring is broadly covered along with its biological
significance.
Una aproximación a la situación de las personas discapacitadas en el ámbito del empleo ordinario. Especial referencia a la Ley 15/2022, de 12 de julio, integral para la igualdad de trato y no discriminación
Authors: Dozo Mougán Irene
Published: July 2023

El concepto de discapacidad como factor explícito de no discriminación ha evolucionado a lo largo del tiempo, lo que ha supuesto un avance en la igualdad de oportunidades y de trato de las personas con discapacidad y su inclusión social. El desarrollo de disposiciones, políticas y acciones han contribuido de manera crucial a garantizar los derechos más esenciales de este vulnerable colectivo como la personalidad, la integridad, la independencia y la inclusión. No obstante, la adopción de métodos eficaces que faciliten la incorporación de trabajadores que sufren alguna limitación a un mercado de trabajo igualitario e inclusivo es una tarea que aún queda por resolver.
Structural Determinants of Financial Sustainability of Listed Financial Companies in Nigeria
Authors: Doshiro Musa Umar , Ibrahim Hauwa Victoria , Usman Tanimu Gadi
Published: July 2023

The study examined the effect of structural determinant of financial sustainability of listed financial companies in Nigeria from 2012-2021. The study adopted longitudinal research design with panel multiple regression model was used for the analysis. The study found that managerial ownership has a positive significant effect on financial sustainability, institutional ownership has negative insignificant effect on financial sustainability while foreign ownership has positive insignificant effect on financial sustainability of listed financial companies in Nigeria. Based on the finding, the study recommends that managers should be encouraged to acquire more shares since it will lead them to be more committed to the company’s operations that can increase financial sustainability of the company. Also, the banks should encourage foreign investors to acquire shares because the resultant distribution of ownership among different groups can impact on managerial opportunism, which subsequently has implications for managerial behavior and corporate performance. This, they will monitor and check the management behaviour whenever necessary.
Novel insights into D-Pinitol based therapies: a link between tau hyperphosphorylation and insulin resistance
Authors: Medina-Vera Dina , López-Gambero Antonio Jesús , Navarro Juan Antonio , Sanjuan Carlos , Baixeras Elena , Decara Juan , de Fonseca Fernando Rodríguez
Published: July 2023

Alzheimer’s disease is a neurodegenerative disorder characterized by the amyloid accumulation in the brains of patients with Alzheimer’s disease. The pathogenesis of Alzheimer’s disease is mainly mediated by the phosphorylation and aggregation of tau protein. Among the multiple causes of tau hyperphosphorylation, brain insulin resistance has generated much attention, and inositols as insulin sensitizers, are currently considered candidates for drug development. The present narrative review revises the interactions between these three elements: Alzheimer’s disease-tau-inositols, which can eventually identify targets for new disease modifiers capable of bringing hope to the millions of people affected by this devastating disease.
Physiological and pathological functions of circular RNAs in the nervous system
Authors: Zhou Min , Li Shi , Huang Chuan
Published: July 2023

Circular RNAs (circRNAs) are a class of covalently closed single-stranded RNAs that are expressed during the development of specific cells and tissues. CircRNAs play crucial roles in physiological and pathological processes by sponging microRNAs, modulating gene transcription, controlling the activity of certain RNA-binding proteins, and producing functional peptides. A key focus of research at present is the functionality of circRNAs in the nervous system and several advances have emerged over the last 2 years. However, the precise role of circRNAs in the nervous system has yet to be comprehensively reviewed. In this review, we first summarize the recently described roles of circRNAs in brain development, maturity, and aging. Then, we focus on the involvement of circRNAs in various diseases of the central nervous system, such as brain cancer, chronic neurodegenerative diseases, acute injuries of the nervous system, and neuropathic pain. A better understanding of the functionality of circRNAs will help us to develop potential diagnostic, prognostic, and therapeutic strategies to treat diseases of the nervous system.
Metabotropic glutamate receptors (mGluRs) in epileptogenesis: an update on abnormal mGluRs signaling and its therapeutic implications
Authors: Huang Leyi , Xiao Wenjie , Wang Yan , Li Juan , Gong Jiaoe , Tu Ewen , Long Lili , Xiao Bo , Yan Xiaoxin , Wan Lily
Published: July 2023

Epilepsy is a neurological disorder characterized by high morbidity, high recurrence, and drug resistance. Enhanced signaling through the excitatory neurotransmitter glutamate is intricately associated with epilepsy. Metabotropic glutamate receptors (mGluRs) are G protein-coupled receptors activated by glutamate and are key regulators of neuronal and synaptic plasticity. Dysregulated mGluR signaling has been associated with various neurological disorders, and numerous studies have shown a close relationship between mGluRs expression/activity and the development of epilepsy. In this review, we first introduce the three groups of mGluRs and their associated signaling pathways. Then, we detail how these receptors influence epilepsy by describing the signaling cascades triggered by their activation and their neuroprotective or detrimental roles in epileptogenesis. In addition, strategies for pharmacological manipulation of these receptors during the treatment of epilepsy in experimental studies is also summarized. We hope that this review will provide a foundation for future studies on the development of mGluR-targeted antiepileptic drugs.
Transcriptional regulation in the development and dysfunction of neocortical projection neurons
Authors: Wang Ningxin , Wan Rong , Tang Ke
Published: July 2023

Glutamatergic projection neurons generate sophisticated excitatory circuits to integrate and transmit information among different cortical areas, and between the neocortex and other regions of the brain and spinal cord. Appropriate development of cortical projection neurons is regulated by certain essential events such as neural fate determination, proliferation, specification, differentiation, migration, survival, axonogenesis, and synaptogenesis. These processes are precisely regulated in a tempo-spatial manner by intrinsic factors, extrinsic signals, and neural activities. The generation of correct subtypes and precise connections of projection neurons is imperative not only to support the basic cortical functions (such as sensory information integration, motor coordination, and cognition) but also to prevent the onset and progression of neurodevelopmental disorders (such as intellectual disability, autism spectrum disorders, anxiety, and depression). This review mainly focuses on the recent progress of transcriptional regulations on the development and diversity of neocortical projection neurons and the clinical relevance of the failure of transcriptional modulations.