bluuebunny/crossref_metadata_2025 huggingface dataset:
MAX WEBER’İN SİYASET TEORİSİ ÜZERİNE BİR DEĞERLENDİRME
Authors: ARI Serdar
Published: October 2022

Max Weber, siyaseti meslek olarak seçecek kişilerle ilgili düşüncelerini ilk kez 1919 yılında Münih Üniversitesi Liberal Sol-Hür Öğrenciler Birliği’nde, “Meslek Olarak Siyaset” başlığı altında verdiği konferansta öğrenci topluluğu ile paylaşmıştır. Bu çalışmanın amacı, kendisi ünlü bir Alman sosyolog, ekonomist ve düşünür olan Max Weber’in hayatının son dönemlerinde dile getirdiği siyasetle ilgili düşüncelerini siyasi sorumluluk, devlet, bürokrasi, egemenlik (otorite) ve etik bağlamında açıklamaktır. Yine Max Weber tarafından ortaya konulan, devlet memurlarının nitelikleri ve çalışma prensipleri ve siyasi arenada takınmak zorunda oldukları tavır ve davranışları daha önce hiç dile getirilmemiş olmaları açısından çalışmamızda önemli yer tutmaktadır. Bu anlamda Max Weber, bir siyasetçide olması gerektiğine inandığı nitelikleri özellikle sorumluluk ve inanç etiği bağlamında ortaya koymuştur. Ayrıca devlet memurlarının tarafsız kalmaları ve hınç duygusundan uzaklaşarak görevlerini yerine getirmeleri gerektiğini ortaya koymuştur.
الاحتياجات التدريبية لمعلمي الصفوف الأولى من وجهة نظرهم بمدينة مأرب
Authors: البدجي د. سعاد محمد ناجي
Published: October 2022

هدفت الدراسة الحالية إلى التعرف على الاحتياجات التدريبية لمعلمي الصفوف الأولى من وجهة نظر المعلمين أنفسهم بمدينة مأرب. وقد اتبعت الدراسة المنهج الوصفي، ولتحقيق هدف الدراسة تم إعداد استبانة وتكونت من (38) فقرة، توزعت على أربعة مجالات (تخطيط للدروس، تنفيذ الدروس، إدارة الصف والعلاقات الإنسانية، أساليب التقويم.)، تم تطبيق الاستبانة على عينة من معلمي الصف تكونت من (49) معلماً ومعلمة من معلمي الصفوف الأولى بمدينة مأرب، وأظهرت الدراسة النتائج الآتية:أن درجة الاحتياجات التدريبية لمعلمي الصفوف الأولى كانت تمثل احتياجاً كبيراً، كما أظهرت وجود فروق دالة احصائياً في تقدير الاحتياجات التدريبية تعزى لمتغير المؤهل، في حين لم تظهر فروق دالة إحصائياً لمتغير سنوات الخبرة.
Genotypic difference in response of chlorophyll content and peroxidase activities to salt stress in triticale
Authors: Uysal Pınar , Ata Sinan
Published: October 2022

The goal of the present study was to determine the salinity resistance of 5 triticale genotypes. Salt-stress experiments were carried out under tissue culture conditions. Regenerated seedlings of five genotypes were exposed to 0 and 100 mM NaCl. Peroxidase activity and pigment content were determined for seedling applied with salt for 7, 14, and 21 days. Peroxidase activity was observed in the triticale seedlings of salt stress in in-vitro conditions. Melez 2001 and Mikham 2002 were determined to be more responsive to stress severity than the other genotypes in terms of chlorophyll content. Our results showed that there was a positive correlation between chlorophyll content and 100 mM concentration salt stress in salt-resistant triticale genotypes.
Investigation of the effects of different genotypes on regeneration capacity in Triticale
Authors: Bezirganoğlu İsmail , Karaman Serap , Reisoğlu Beyza , Yazıcılar Büşra
Published: October 2022

Triticale (x Triticosecale Wittmack) is a synthetic amphiploid cereal that grows on about 3 million hectares in the world. It is grown mostly for forage or animal feed, although some triticale-based foods can be purchased at health food stores or are found in some breakfast cereals. Mature embryos of two triticale cultivars (Ümran Hanım and Melez 2001) were used as the resources explants. The effects of one auxin type (2,4-D) and three various concentrations, (4.0 mg/l; 8mg/l; 12.0mg/l) callus formation and plant regeneration were determined. Callus formation values were detected over 85% in three concentrations. In terms of results, the highest embryogenic callus formation rate was determined 46.91 % at 12 mg/l of Ümran Hanım dicamba. However, the lowest embryogenic callus formation rate was found with a value of 12.86% in Ümran Hanım's 2,4-D 8.0 mg/l hormone application. The highest regeneration capacity was determined at 12.09% at a dose of 12.0 mg/l of Mikham 2001 2,4-D. However, the lowest regeneration capacity was determined at 2.2% at the dose of 4 mg/l of Ümran Hanım 2,4-D. Our results displayed that auxin type and hormone dosage were very significant on the triticale mature embryos.
The potential role of long non-coding RNAs and micro RNAs in insects: From junk to luxury
Authors: Shafi Insha , Gani Mudasir , Shafi Sadiah , Hassan Taskeena , Mantoo Mohd. Ayoub
Published: October 2022

Noncoding RNAs (ncRNAs) play an important role in almost all biological processes and comprise a layer of internal signals
that have a potential control on various levels of gene expression. The research in the field of ncRNAs has progressed a lot
owing to the recent developments in sequencing methods and information analysis. A large number of ncRNAs have been
identified in insects from the RNA-Seq data or transcriptomes and they have important regulatory functions at the epigenetic,
transcriptional, or post-transcriptional levels. The technological innovations have made it possible to discover ncRNAs from
both beneficial (honeybees, silkworm, etc.) and harmful insects (Plutella xylostella, Helicoverpa armigera, Bactrocera species,
aphids etc.). The characterization and utilization of ncRNAs in the field of insect science have become a worldwide research
focus and they are believed to have potential applications in insect pest management and the prevention and management of
diseases of beneficial insects.
Comparison of Iflavirus Diversity in Agricultural and Forest Pest Lepidoptera
Authors: Eroğlu Gözde Büşra
Published: October 2022

Iflaviridae is a novel and important family of viruses in the Picornavirales order that infects invertebrates. Iflaviruses are non-enveloped, linear, positive single-stranded RNA viruses. The importance of iflaviruses in agriculture and forestry is twofold because these viruses, both cause economic loss by making insects such as honey bees and silkworms ill and prevent economic loss by making agricultural and forest pest insects ill. Therefore, iflaviruses contain highly interesting isolates that infect both beneficial and harmful insects in agriculture. Its genome structure, like most RNA viruses, has a very small genome size (8.8-10 kb), with a single open reading frame in the entire genome. The genomes of 14 infective iflaviruses that infect agricultural and forest pest insects from different countries have been analyzed so far. In this study, the similar relationship between these 14 viruses, whose complete genomes are available, was analyzed according to the complete sequence of the polyprotein. The results showed that the virus isolates obtained from forest pest insects were closely related to each other. Similarly, it was revealed that the iflaviruses obtained from insects that damage agricultural products are more similar to each other. In addition, the results from this study support previous studies on adding a new genus to the Iflaviridae family, which has only one genus.
TECENDO REFLEXÕES SOBRE AS QUESTÕES DE GÊNERO E SEXUALIDADE NOS ANOS INICIAIS DO ENSINO FUNDAMENTAL
Authors: Do Nascimento Rosilaine Moreira , Rios Pedro Paulo Souza
Published: October 2022

O estudo buscou analisar de que maneira se dá a problematização acerca dos processos de construção e reconstrução das relações de gênero, sexualidades e suas interseccionalidades nos processos ensinoaprendizagem no Ensino Fundamental I. Para tanto, nosso aporte teórico se deu a partir dos estudos teóricos na perspectiva de gênero e educação em Louro (1997; 2008) e Rios (2018) e gênero e infância em Felipe (2013) dentre outros/as pesquisadores/as de gênero e suas intersecções. A partir da abordagem qualitativa descritiva, optou-se por procedimentos de pesquisa o questionário de múltipla escolha, entrevistas semiestruturadas, e análise documental. A pesquisa foi realizada numa Escola pública de Ensino Fundamental do Município de Campo Formoso – Bahia, e teve como sujeitos estudantes do ensino fundamental I, a professora da turma e a coordenadora. A partir deste estudo destacamos a importância de estabelecermos, no âmbito do contexto escolar o debate sobre as questões de gênero e sexualidade, em seus diversos atravessamentos. Considerando que tais temas são inerentes à formação humana, fazendo parte do cotidiano dos/as estudantes desde a infância.
A TELEMEDICINA COMO FERRAMENTA DE CONTINUIDADE DE CUIDADOS EM SAÚDE ÀS PESSOAS PRIVADAS DE LIBERDADE VIVENDO COM HIV/AIDS EM PERÍODO DE PANDEMIA: RELATO DE EXPERIÊNCIA
Authors: Arze Wilma Nancy Campos , Costa Marta Cossetin , Campos Adriel Chihyun Chung
Published: October 2022

Introdução: O contexto de Pandemia Covid-19 representou um entrave a manutenção dos cuidados em saúde, inclusive das crônicas infecciosas tais como o HIV/AIDS, em especial, a população em privação de liberdade, que agrega as limitações inerentes ao isolamento social, a necessidade de transporte e escolta para o deslocamento ao serviço especializado.  Neste contexto, a Telemedicina se configura como ferramenta de continuidade da assistência, permitindo a superação das barreiras geográficas e físicas e, mantendo-se a segurança do usuário. Objetivo: Relatar a experiência de atendimento médico mediado por tecnologias de informação e comunicação às pessoas privadas de liberdade vivendo com HIV/AIDS de duas unidades penais do extremo oeste paranaense no período de julho de 2020 à março de 2021. Método: Trata-se de um estudo descritivo, do tipo relato de experiência. Resultados:  Foram realizados atendimentos médicos de acompanhamento mediado por Tecnologias de Informação e Comunicação (TICs) a dezesseis PPL vivendo com HIV/AIDS em duas unidades penais da região do extremo oeste paranaense. O processo iniciou-se com a realização de exames de rotina e de acompanhamento de CD4 e carga viral e acolhimento das PPL pelo profissional enfermeiro. A Teleconsulta utilizou-se da Plataforma Mymedi, e, constitui-se de ação multiprofissional (médico e enfermeiro). Os usuários mostraram-se receptivos e participativos, obtendo-se no período de acompanhamento manutenção das cargas virais indetectáveis em 93,75% das PPL, e, nenhuma demanda de remoção para atendimento externo e/ou internação hospitalar no período. Conclusão: o atendimento médico mediado por TICs constituiu-se de mais uma ferramenta na busca da garantia do direito de cuidado em saúde às PPL, permitindo superar as barreiras físicas, em especial, impostas pela Pandemia Covid-19, diminuir o tempo de espera para a consulta médica, dispensou as escoltas externas a unidade penal, repercutindo em maior segurança às PPL e equipes de segurança.
UMA SÍNTESE DOS INDICADORES DE DESENVOLVIMENTO HUMANO E SUSTENTABILIDADE PARA A CIDADE DE SÃO PAULO
Authors: Borelli Elizabeth , Neto Aurélio Sbizzarro
Published: October 2022

A proposta deste artigo é sintetizar os principais indicadores de desenvolvimento humano e de sustentabilidade para a cidade de São Paulo, numa abordagem holística, de forma articulada, a partir das conceituações teóricas de Mahbub Ul Haq e Amartya Sen, apresentando a metodologia das principais métricas em uso. Efetuou-se uma análise descritiva e crítica, com base nos dados oficiais disponíveis.  Elaborou-se um panorama referente ao estágio atual e à evolução recente do desenvolvimento humano e sustentabilidade da cidade de São Paulo, visando delinear um perfil do estágio de desenvolvimento humano sustentável, através de indicadores representativos. O objetivo é evidenciar a complexidade e a abrangência do tema, bem como sugerir elementos capazes de oferecer subsídios para o acompanhamento futuro, que possam contribuir para a elaboração de políticas públicas eficientes, visando promover a ampliação do bem-estar social, em sentido amplo.
Andragogía: un límite al edadismo (la Generación Siglo 20/21 un modelo de referencia)
Authors: De Faramiñán Gilbert Juan Manuel
Published: October 2022

A pesar de encontrarnos en pleno siglo XXI, aún se mantienen los estereotipos vejatorios sobre la edad de los seres humanos que han dado lugar al neologismo “edadismo”. Frente a lo cual se impone la necesidad de un cambio de paradigma, que se apoye en las instituciones y en las normas jurídicas, con el fin de poder reivindicar los derechos y el respeto a los mayores. En este sentido, se hacen necesarios proyectos de formación, tanto en las nuevas generaciones como en las generaciones adultas, con el fin de reivindicar la experiencia y la edad. Para lo cual, se hace oportuno un esfuerzo andragógico con el propósito de visualizar la importancia de los años, e incluso nos ha parecido sugerente hablar de la Generación Siglos 20/21, con el propósito de unir a aquellas personas que hayan logrado vivir el puente entre estos dos siglos.
ANALYSIS OF STUDENT FRIENDSHIPS AT MI RADEN INTAN GADINGREJO BASED ON: Perspectives OF George Caspar Homans
Authors: Purwanti Eri , Lestari Yuni , Amsir Rojani
Published: October 2022

Manusia perlu membangun relasi dengan manusia lainnya karena pasti akan membutuhkan bantuan orang lain untuk mencukupi kebutuhannya. Interaksi yang terjadi antara dua individu atau lebih menghasilkan relasi. Salah satu relasi yang bisa dibentuk yakni berupa pertemanan. Hubungan pertemanan memiliki beberapa aspek yang mampu menjalin adanya interaksi antar individu salah satunya yakni adanya timbal balik. Hal ini sesuai dengan teori yang dicetuskan oleh George Caspar Homans yaitu teori pertukaran. Salah satu karakteristik teori pertukaran yang mencolok yakni cost and reward. Manusia Ketika melakukan interaksi selalu mempertimbangkan cost (biaya atau pengorbanan) dengan reward (hadiah atau manfaat) yang didapat dari interaksi. Pada hubungan pertemanan dapat bertahan. Penelitian ini termasuk ke dalam jenis penelitian deskriptif kualitatif dengan metode pengumpulan data menggunakan wawancara. Hasil dari penelitian ini mengungkapkan bahwa analisis pertemanan siswi kelas II Madrasah Ibtidaiyah dengan yang diungkapkan oleh Homans pada teori pertukaran. Hubungan pertemanan tersebut cenderung bertahan dengan sebuah interaksi karena kedua individu memperoleh keuntungan berupa hadiah.
ISLAMIC RELIGIOUS EDUCATION IN SHAPING CHARACTER IN HIGHER EDUCATION
Authors: Evi Gusliana  , Nurlela
Published: October 2022

AbstractCharacter formation is associated with the term ethics, morality, and or values related to moral strength, connoting "positive" and "good" not neutral. Therefore, character education more broadly can be interpreted as education that develops cultural values and national character in students so that they have values and character as their own character, apply these values in their lives as members of society, and religious citizens. nationalist, productive, and creative. The application of Islamic education needs to be done by increasing taqwa to God Almighty and noble character is a manifestation of the faith that is believed by everyone. Therefore, faith and piety that are united in a person will shape a person into a good, strong, honest and responsible person. With a strong character, it will be very useful for the unity and future of the nation. Character education in higher education is very important because it creates a young generation that is honest, polite and ethical. [1]Keywords: Islamic religious education, character, higher education
Analysis of the impacts of health service closure policy on Indonesian nursing during COVID-19 pandemic: A literature review
Authors: Casman Casman , Indah Pertiwi Retno , Chandra Muhammad , Mahardika Putri , Fahmi Ismail , Fitria Utami Ayu , Nur Rohmah Ulfa
Published: October 2022

Background: The COVID-19 pandemic has been over yet; one of the effects of this pandemic is plenty of hospitals in Indonesia have been applying for temporary health service closure.

Objective: This study aimed to analyse the effect of health service closure during the COVID-19 pandemic.

Design: Simple study literature is the method for this study. 

Data Sources: This study used two different search processes. The first search process came from online news platforms (detik.com, kompas.com, and okezone.com), which used a combination of the words “COVID-19”, “emergency room”, “hospital”, and “closed” during November 2020. The second search was from the database (CINAHL, ProQuest, ScienceDirect, PubMed, SpringerLink, and Wiley Online). 

Review Methods: The guidelines of the second search used Preferred Reporting Items for Systematic Review and Meta-Analysis. Both searching processes applied COVID-19 and hospital closed or emergency department closed as the keywords from November 2020-January 2021. 

Results: The first finding showed more than 300 news about health service closure, and the second showed 13 selected articles. There were 42 health service unit closures from 16 provinces in Indonesia. These closures had disadvantages effect for patients, nursing care and nursing education side.

Conclusions: Total or partial health service closure could be happened due to increased patient capacity, delays in the treatment of the patient, many nurses getting infected by COVID-19, and nursing students cannot practice directly. Therefore, this issue needs innovative solutions to keep the nursing student placement going well by considering safety for the patient, nurses, nursing students, and trainer/ facilitator.
THE EFFECT OF ADDITIONAL DADIH ON LACTIC ACID BACTERIA AND NUTRITIONAL VALUE OF PUDDING AS A FOOD SUPPLEMENTATION
Authors: HELMIZAR  , AZRIMAIDALIZA  , RESTU SAKINAH  , ARIEF YANDRY
Published: October 2022

Dadih is a dairy product obtained from fermented buffalo milk in West Sumatra, Indonesia. It contains various nutrients and probiotics that are beneficial for prenatal supplementation and pregnancy outcomes. In this study, a pudding enriched with dadih was formulated. The study was conducted in November-December 2019 at the Nutrition Laboratory Andalas University. The design of this study was a True Experiment using a Completely Randomized Design (CRD) with two replications consisting of four formulas. They were F0, F1, F2, and F3 with the addition of dadih at 0, 80, 90, and 100 g, respectively. Analysis of nutritional value and the number of Lactic Acid Bacteria (LAB) was performed. Based on the nutritional value analysis, 100 g of dadih pudding contains 11.59% of carbohydrate, 1.24% of protein, 1.09% of fat, with a total of 61.13 calories for F0; 10.41% of carbohydrate, 2.29% of protein, 3.29% of fat, with a total of 80.41 calories for F1; 10.12% of carbohydrate, 4.74% of protein, 3.32% of fat, with a total 89.32 calories for F2; and 11.84 % of carbohydrate, 3.05% of protein, 3.13% of fat, with a total 87,73 calories for F3. The result of the LAB test of dadih pudding showed that: F0 at 3.1 × 103 (CFU/g); F1 at 1.7 × 109 (CFU/g); F2 at 2.4 × 109 (CFU/g), and F3 at 2.4 × 109 (CFU/g). While the result of the Kruskall Wallis test showed that there was a significant difference between the hedonic test and the hedonic quality test of four dadih pudding formulas (p<0.000). The chosen formula was F3 with the highest nutrition value average of 87.73 kcaL total calories. Dadih pudding is recommended as a food supplementation because it is good for the digestive system and can increase the immune system of pregnant women.
Oryzias latipes (JAPANESE MEDAKA) AS GENETIC MODEL TO STUDY CAUSATIVE GENES OF EPILEPSY DISEASE: AN IN-SILICO APPROACH
Authors: MOHAMED YUNUS NORFATIMAH , MAT YUSUF UMI NABILA , AHMAD LYENA WATTY ZURAINE , KAMBOL ROZIAH , ARIS FARIZAN , ZAKARIA NURUL AILI
Published: October 2022

Epilepsy is a chronic neurological disorder that has affected around 50-70 million people worldwide. Various animal models have previously been used in epilepsy research. To expand the knowledge of the disease, a new animal model is suggested to be explored considering the genetic and phenotypic heterogeneity that contributes to the complexity of the disease. This study was undertaken to analyze 14 causative genes of epilepsy disease in Japanese medaka (Oryzias latipes), humans, and the established model of this disease which is zebrafish (Danio rerio) by assessing the variation in the genes by using MEGA X and predicting the functional motif and secondary structure of the proteins by using PROSITE and GORIV respectively. Results from the variation analysis showed the lowest percentage of conserved genes in Japanese medaka was 60%.50% of the genes of Japanese medaka were found to be more conserved than zebrafish in comparison to a human. The functional motifs present in all genes in Japanese medaka showed the same motifs present in humans. All the secondary structures of Japanese medaka genes were predicted to contain the alpha helix, extended strand, and random coil. In conclusion, it can be inferred that Japanese medaka could be a reliable animal model for epilepsy disease.
A 96-WELL-PLATE–BASED METHOD FOR THE ESTIMATION OF ALPHA-AMYLASE ACTIVITY USING MINIATURISES 3,5-DINITROSALICYLIC ACID (DNSA) COLORIMETRIC METHOD
Authors: NOOR MOHAMAD ZIN NOOR SYAFFINAZ , AZMI NUR AIN SABRINA , ANUAR NURSARAH SYAMIMI , SHAFIE SYAHIRAH AIN , MAZNAN MUHAMAMMAD AIMAN FARIS , GOH YONG MENG , SAMSULRIZAL NURDIANA
Published: October 2022

The DNSA assay has been widely employed for the in vitro detection and quantification of alpha-amylase inhibitory activity. However, the conventional method is associated with inconsistencies between protocols and requires a large volume of samples and other assay reagents that can compromise accurate quantitation. Therefore, the study aimed to develop a reliable, simple, and rapid analytical method for determining α-amylase activity. The developed method was carried out in 96-well microplates with a total volume of 250 µL and a total assay time of 1 hr, including pre-incubation. The method was validated for linearity, the limit of detection (LOD), the limit of quantitation (LOQ), and precision. A higher coefficient of determination (R2) value was observed for the developed method as compared to the conventional method (0.9983 ± 0.0003 vs 0.9667 ± 0.0383). The coefficient of variation (CV%) of each data point was less than 15%, indicating excellent data precision. The optimum assay conditions were identified at 2 U/mL of enzyme solution and 5% (w/v) starch solution at 50 °C incubation temperature with an IC50 value of 0.026 ± 0.005 mg/mL. It is concluded that the developed method is practical, precise, and accurate for estimating α-amylase inhibitory activity and would provide reproducible results.
ENHANCING EMOLLIENT PROPERTIES OF NATURAL AND STRUCTURED VIRGIN COCONUT OIL CREAMS ON SKIN CONDITIONS USING NON-INVASIVE SKIN BIOPHYSICAL METHODS
Authors: IBRAHIM SALIZATUL ILYANA , MATMIN JUAN , HAIRUL NURIANA MUNIRAH , ABDUL MAJEED ABU BAKAR
Published: October 2022

This study aims to evaluate the emollient properties of natural-based oil creams on skin conditions. The focus is primarily on natural virgin coconut oil (VCO) and structured VCO (SVCO) which contain medium-chain triglycerides (MCTs) that have been reported to have a permeation enhancement effect on the lipophilic active ingredient. SVCO, which contains a higher amount of MCTs than VCO, was produced by lipase-catalyzed acidolysis of caprylic/octanoic acid (eight-carbon chain) and VCO. The emollient cream was prepared using the oil in water (o/w) formulation cream and it consisted of 30% (w/w) of oils, emulsifying wax, and deionized water. While in the oil phase, 5% (w/w) α-tocopherol, the model lipophilic active ingredient was added to the cream. Significant effects (p<0.05) were statistically produced in the skin moisture content, transepidermal water loss (TEWL), and skin elasticity values for all formulations as compared to the skin at T0 (before application) after the short- and long-term study periods. The skin smoothness (SEsm) and skin roughness (SEr) values, which are indicators of the skin condition, also showed significant improvement. The results indicated that VCO and SVCO creams exerted an emollient effect when applied topically and also acted as skin permeation enhancers in the formulation.
HDL AND ITS SUBPOPULATION (HDL2 AND HDL3) PROMOTE CHOLESTEROL TRANSPORTERS EXPRESSION AND ATTENUATES INFLAMMATION IN 3T3-L1 MATURE ADIPOCYTES INDUCED BY TUMOR NECROSIS FACTOR ALPHA
Authors: ABD MUID SUHAILA , AWANG JALIL REMEE , HARUN NOOR HANISA , MOHD NAWAWI HAPIZAH , RUTH FROEMMING GABRIELE ANISAH
Published: October 2022

Obesity activates inflammation causing dysfunction of adipocytes. Increasing high-density lipoprotein (HDL) levels in obesity may be beneficial in overcoming this effect. However, not much data is available on the effects of HDL and its subpopulations in inflamed adipocytes. The objective of this study was to investigate the effects of total HDL (tHDL) and the comparison between its subpopulations (HDL2 & HDL3) on protein and gene expression of cholesterol transporters, inflammation, and adipokines in TNF-α stimulated 3T3-L1 mature adipocytes. TNFα alone had lower adiponectin and higher protein and gene expression of IL-6 and NF-ĸβ (p65) compared to unstimulated adipocytes and these effects were attenuated by HDLs especially HDL3 (in most of the biomarkers). HDL and its subpopulation had higher cholesterol transporters expression in 3T3-L1 mature adipocytes induced by TNF-α compared to unstimulated cells. Increment of cholesterol transporters expression by HDL leads to reduce secretion of inflammatory markers [IL-6 & NF-kB (p65)] and visfatin and increases adiponectin secretion in the inflamed mature adipocytes. HDL exhibits beyond its reverse cholesterol transporter property by exhibiting anti-inflammatory effects thru the deactivation of NF-ĸβ (p65). This may contribute to reducing the progression of obesity-related complications.
ANTI-INFLAMMATORY EFFECTS OF Vitex trifolia LEAVES HYDROALCOHOLIC EXTRACT AGAINST HYDROGEN PEROXIDE (H2O2)- AND LIPOPOLYSACCHARIDE (LPS)-INDUCED RAW 264.7 CELLS
Authors: GHAFARI AHMAD TAMIM , JAHIDIN AISYAH HASYILA , ZAKARIA YUSLINA , HAZIZUL HASAN MIZATON
Published: October 2022

Inflammation is the human body’s defensive response against harmful events and a hallmark of many chronic conditions. Commonly, pharmacological approaches to treat inflammation include the use of non-steroidal anti-inflammatory drugs (NSAIDs) that could potentially possess life-threatening side effects after prolonged use. Hence there is a need for safer alternatives with fewer possible side effects. Vitex trifolia is a shrub from the family Verbenaceae, which possesses potential anti-inflammatory effects and is traditionally used to treat inflammation-related diseases in several Asian countries. This study aimed to explore the antioxidant and anti-inflammatory effect of V. trifolia leaves hydroalcoholic extract (VT) against murine macrophages (RAW 264.7 cells) induced with hydrogen peroxide (H2O2) and lipopolysaccharide (LPS). The reactive oxygen species (ROS) production was evaluated in the H2O2-induced macrophages. On the other hand, the interleukin (IL)-1β, IL-6, tumor necrosis factor (TNF)-α, and cyclooxygenase (COX) levels were quantified in the LPS-induced macrophages. VT (25 & 50 µg/mL) showed protective effects and significantly (p<0.05) increased the cell viability and reduced the ROS production compared to that of macrophages treated with 300 µM H2O2 alone. Additionally, VT (50 & 100 µg/mL) significantly (p<0.05) reduced LPS-induced TNF-α and IL-6 levels and COX activity compared to the macrophages treated with LPS (1 µg/mL), alone. However, VT and diclofenac had no inhibitory effect on IL-1β induced by LPS. Moreover, a significant positive correlation was found between VT antioxidant and anti-inflammatory effects. Concisely, these outcomes showed the potential antioxidant and anti-inflammatory effect of VT with a positive correlation between these protective actions. Therefore, our results suggest that VT may serve as a source of nutraceutical compounds with impending antioxidant and anti-inflammatory activities. However, further molecular investigations on the isolated compounds of the plant and in vivo studies are suggested for future work.
A Comprehensive Review on the Effect of Filler Materials on Engineering Properties of Asphalt Concrete Mixes
Authors: Olaiya Ogunleye Ranti , Tolulope Ata Bisola , Ayuba Thabita
Published: October 2022

The effect of filler materials on the properties of bituminous concrete was reviewed in this paper. Flexible pavement layer is made up of asphalt concrete. It is the commonest type of pavement in the world. Asphalt concrete contains aggregates, bitumen binder and fillers. The Asphalt concrete has voids which needs to be filled for better performance of its functions. Fillers help to fill voids and change the physical and chemical properties of asphalt concrete and bitumen combines with filler to forms mastic that holds the aggregates together. Asphalt Institute recommended 4-8% fillers for use. The recent developments in technology is geared towards the use waste materials as fillers in concrete production. It was revealed in this review that Marble dust and Calcium Carbide Residue (CCR) can be used in bituminous mix as alternative to conventional fillers in asphalt mixes. The waste bagasse and coconut peat fillers give mastic viscosity similar to limestone filler but higher than granite filler. Concrete dust and brick dust as fillers in bituminous mix improve flow value, Marshall stability and physical characteristic of bitumen. The conclusion of this review analysis shows that fillers in bituminous mix reduces the problem associated with waste disposal and high concentration of calcium carbonate in waste ash can help to reduce rutting and moisture damage potentials.
MEREKONSTRUKSI KISAH PEMBANGUNAN MENARA BABEL DARI PERSPEKTIF SPRITUALITAS KAUM PENTAKOSTAL
Authors: Manurung Kosma
Published: October 2022

The Bible that believers believe as a way of life tells many interesting stories to study and one of them is the story of the construction of the tower of Babel. This study specifically seeks to reconstruct the story of the construction of the tower of Babel from the perspective of the spirituality of the Pentecostals. By using text analysis methods and literature studies, the researcher attempts to systematically and deeply analyze the conditions of the times at that time, analyzing the passage of Genesis 11:1-9 regarding the construction of the tower of Babel in order to gain a comprehensive understanding to correlate with the perspective of the Pentecostals interpreting this story. . It is concluded that for the Pentecostals, the story of the construction of the Tower of Babel is interpreted as the limitation of human effort, misguided unity, it is necessary to prioritize the role of the Holy Spirit, and God's judgment.Alkitab yang diyakini orang percaya sebagai pedoman hidup menceritakan banyak kisah yang menarik untuk dikaji dan salah satunya adalah kisah pembangunan menara Babel. Penelitian ini secara khusus berupaya merekonstruksi kisah pembangunan menara Babel dari perspektif spritualitas kaum pentakostal. Dengan menggunakan metode analis teks dan kajian literatur, peneliti berupaya untuk menganalisa secara sistimatik dan mendalam kondisi zaman pada waktu itu, menganalisis perikop Kejadian 11:1-9 terkait pembangunan menara Babel ini guna mendapatkan pemahaman yang komprehensif untuk dikolerasikan dengan perspektif kaum pentakostal memaknai kisah ini. Disimpulkan bahwa bagi kaum pentakostal kisah pembangunan menara babel ini dimaknai sebagai keterbatasan usaha manusia, kesatuan yang salah sasaran, perlu mengedepankan peran Roh Kudus, dan penghakiman Tuhan.
Sub-Clavicular Hibernoma: A Rare Diagnosis of Lipomatous Tumor
Authors:   Radiology resident, Université catholique de Louvain, CHU UCL Namur, Department of Radiology, Avenue G Thérasse 1, 5530, Yvoir,Belgium, Zaïd Boughaleb , Stéphane Mazy ,   Université catholique de Louvain, CHU UCL Namur, Department of Radiology, Place L Godin 15, 5000, Namur, Belgium, Gebhard Muller ,   Institut de Pathologie et Génétique, Av. Georges Lemaître 25, 6041 Charleroi, Belgium, Aline Berners ,   Université catholique de Louvain, CHU UCL Namur, Department of Plastic Surgery, Place L Godin 15, 5000, Namur, Belgium., Françoise Kayser ,   Université catholique de Louvain, CHU UCL Namur, Department of Radiology, Avenue G Thérasse 1, 5530, Yvoir, Belgium
Published: October 2022

Lipomatous tumors are the most common soft tissue tumors, including a large variety of benign and malignant lesions. Hibernoma is a benign lipomatous tumor originating from the brown adipose tissue inherited from the fetus. The diagnosis is often incidental, since the large majority are asymptomatic or very slow growing. Differential diagnosis with other lipomatous tumors is often challenging. Hence the diagnostic work-up is large and must be multidisciplinary. Biopsy and large resection with sane margins are the standard of care. We describe a 48-year-old male patient with a history of a painless, mobile, slow growing right sub-clavicular mass apparently evolving for eleven years. This patient underwent ultrasound, mammography, MRI, CT Scan and ultrasound guided large core biopsy at different points in time. We describe this case of a well-documented hibernoma of the sub-clavicular region in line with the current literature.
Pretreatments, Dehydration Methods and Packaging Materials: Effects on the Nutritional Quality of Tomato Powder- a review
Authors:   Institute of Agricultural Research, Debre Zeit Centre, EIAR, P.O. Box 2003, Addis Ababa, Ethiopia., Yegrem Lamesgen , Ababel Lijalem ,   Institute of Agricultural Research, Debre Zeit Centre, EIAR, P.O. Box 2003, Addis Ababa, Ethiopia.
Published: October 2022

Pretreatments and drying are commonly used before drying tomatoes to inactivate enzymes, improve the drying process, and improve the quality of dried tomato powders. In this review, the effects of different pretreatments (osmotic solutions), dehydration methods and packaging materials on quality attributes of tomato powder were summarized. These include pretreatments and osmotic agent solution (potassium metabisulfite, calcium chloride, sodium metabisulphite, ascorbic acid, citric acid, sodium chloride and sodium benzoate), thermal blanching (steam blanching and hot water) and non-thermal processes like freezing, sulfuring, etc. and drying methods (oven, sun and indirect solar dryer). The tomato powders were dried to preserve, store, and transport them. Drying implies not only physical changes, which the consumer can easily detect through visual inspection, but also chemical modifications. These are responsible for alterations in color, flavor and nutritional value, which compromise the overall quality of the final tomato powder. Maximum lycopene, vitamin A and C contents were found in freeze dried and direct sundried than samples dried using other methods in low drying temperature. Freeze driers showed in keeping the nutritional quality of tomato powder with a combination of different pretreatments. Different pretreatments including osmotic agent solutions have their own merits and demerits for the final tomato powder. To overcome the drawbacks of nutritional quality, non-thermal pretreatment categories may be a better alternative to thermal blanching, and more fundamental research is required for better design and scale-up.
Optimization of the Technology Sector Stock Portfolio during the Covid-19 Pandemic Using the Markowitz Model
Authors: Meisel Grace , Sinaga Marlina Setia
Published: October 2022

Stock investment in Indonesia has grown quite rapidly in recent years and has attracted the attention of many people . When investing, analysis is needed to get future profits by minimizing stock risk. One of the ways that can be used to minimize risk is to form an optimal portfolio using the Markowitz model. The technology sector is one of the stock sectors that has progressed because of the high public interest in technology-related matters during the Covid-19 pandemic. In this study , the optimal portfolio is a portfolio containing EMTK with a weight of 63% and TFAS with a weight of 37% which produces an expected return value of 0.007488 ( 0.7488%) and a risk value of 0.035000 (3.5%).
Kinerja Kewirausahaan: Literasi Ekonomi, Literasi Digital dan Peran Mediasi Inovasi
Authors: Firmansyah Deri , Dede
Published: October 2022

Penelitian dengan pendekatan kuantitatif menekankan pada analisis statistik yang didukung oleh data kualitatif. Teknik purposive sampling digunakan peneliti dalam memilih sampel sebanyak 39 responden, dengan mempertimbangkan calon responden. Temuan penelitian menunjukkan bahwa literasi ekonomi memiliki hubungan dengan literasi digital untuk memprediksi inovasi dalam mempengaruhi kinerja kewirausahaan kelompok tani muda. Literasi ekonomi dan literasi digital mempengaruhi inovasi. Literasi ekonomi dan literasi digital mempengaruhi kinerja wirausaha baik secara langsung maupun tidak langsung melalui inovasi. Inovasi secara tidak langsung terbukti memediasi pengaruh literasi ekonomi digital terhadap kinerja wirausaha. Pengaruh literasi ekonomi dan literasi digital terhadap kinerja wirausaha, baik secara langsung maupun tidak langsung melalui inovasi, dalam hubungan sebab akibat dan pengaruhnya relatif rendah, serta pengaruh peran mediasi inovasi terhadap kinerja wirausaha. Hal ini dapat menjadi bahan pertimbangan untuk penelitian selanjutnya untuk mengidentifikasinya.
Islamic Financial Infrastructure towards the Establishment of Sharia Central Banks
Authors: Pandoman Agus
Published: October 2022

History notes that America has gotten two giant economic crises both the Great Depression of 1930s and the Financial Crisis of 2008’s. On August 15, 1971 the United States Dollar went down drastically. Without Congressional approval, President Nixon ended the coinage between the United States Dollar and the gold. Consequently the dollar becomes Monopoly Money. After that, the biggest economic boom in history has begun. In 2009, when the economy ran aground, Central Bankers in the world created trillion dollars, yen, pesos, euros and pounds by following a monopoly for bankers.1 The concept has changed to the present time. The distribution of money has become a concept of debt in various forms, including the use of money as a capital instrument. The main contributors to capital in Islamic trade traffic (muamalah) are economic real, not loans (non-loans), actors who direct money used for business capital are concentrated in the form of financing, but after the end of the Gold standard (fiat money), how far the meaning of financing can fulfill justice based on Islamic economics. The concept of the Bank is any camouflage with the money industry, and it is not clear enough, exactly the difference between the Bank and Islamic nuances, because all financial industries are under one container, namely the interest-base central bank. In short, Islamic banking with a financing system, while conventional banking with a loan system. Two different central banks are greatly  needed.
Pengembangan Modul Pembelajaran Matematika Berbasis Inkuiri Kelas X SMAK Arastamar Lotu Tahun Pelajaran 2021/2022
Authors: Nazara Agustina , Harefa Amin Otoni , Harefa Agnes Renostini
Published: October 2022

Tujuan penelitian ini yaitu: Mengetahui kelayakan modul pembelajaran, mengetahui kepraktisan, mengetahui keefektifan modul pembelajaran  berbasis inkuiri pada materi trigonometri kelas X SMAK dalam proses pembelajaran. Penelitian ini merupakan penelitian pengembangan menggunakan model pengembangan ADDIE yang terdiri dari tahap analisis (analysis), perancangan (design), pengembangan (development), implementasi (implementation), danevaluasi (evaluation). Instrument yang digunakan adalah angket validasi yang meliputi aspek kelayakan isi, kelayakan penyajian, dan kelayakan desain, angket respon peserta didik dan tes hasil belajar. Hasil penelitian; (1) validitas isi modul mencapai persentase rata-rata 92,64% (sangat layak), validitas bahasa mencapai persentase rata-rata 100% dengan kriteria sangat layak, validitas desain mencapai persentase rata-rata 100% dengan kriteria sangat layak. (2) kepraktisan modul berdasarkan uji perseroangan mencapai persentase 93,47% dengan kriteria sangat praktis, uji kelompok kecil mencapai persentase 86,08% dengan kriteria sangat praktis, uji lapangan mencapai persentase 91,04% dengan kriteria sangat praktis, (3) efektifitas modul mencapai persentase 88% dengan kriteria sangat efektif.
Kemampuan Guru dalam Mengembangkan Media Pembelajaran Interaktif pada Pembelajaran Tematik melalui Bimbingan Teknis Media Pembelajaran di SD Negeri Cipayung Sukmajaya Kota Depok
Authors: Amaliah
Published: October 2022

Tujuan dari penelitian ini adalah meningkatkan kemampuan guru dalam mengembangkan media pembelajaran interaktif pada pembelajaran tematik di SD Negeri Cipayung Kota  Depok. Mengetahui kualitas pembelajaran Tematik di SD Negeri Cipayung Kecamatan Sukmajaya Kota Depok. Metode Penelitian yang digunakan adalah Penelitian Tindakan sekolah yang sejenis  dengan Classroom  Action  Research  dengan  penelitian  deskriptif  kualitatif,  adalah  penelitian  tindakan  yang  mengacu  pada  conteks  of  discovery. Hasil penelitian menunjukkan nilai kinerja pembuatan media pembelajaran interaktif dengan kualifikasi Amat Baik demikian pula dengan Siklus I, sedangkan pada Siklus II terdapat 3 orang guru atau setara dengan 18,75% menunjukkan dengan kualifikasi Amat Baik.
Analisis Kesalahan Siswa dalam Menyelesaikan Soal Cerita Berdasarkan Teori Newman dan Perilaku Pemecahan Masalah
Authors: Fahmi Abdul Halim  , Puji Savvy Dian Faizati  , Aulia Datul Cahyani  , Anas Malik
Published: October 2022

Researchers found several error problems experienced by students. This error can hinder the student's knowledge process, therefore it is necessary to conduct an error analysis in order to find out the error and the cause of the student's making a mistake. The research method uses a qualitative approach with the type of descriptive research. The researcher gave a story test and then examined and analyzed the test results based on the stages of Newman's error analysis. Furthermore, interviews were held with 6 subjects to reveal data or information that was not revealed in the test. The results of this study indicate that students make the most mistakes in the process skill and encoding stages. In this study also found the behavior shown by students in solving story problems: 1) DTA-Not Proficient; 2) DTA-Limited Context (without justification); and 3) DTA-Limited Context
Peran Mediasi Inovasi: Hubungan Antara Harga dan Kualitas Pelayanan dengan Kepuasan Konsumen
Authors: Eka Pranajaya  , Setiawan Teddy , Firmansyah Deri , Dwinanto P. Susetyo
Published: October 2022

Price, service quality and innovation change the management game in an effort to find the right alternative to increase customer satisfaction as a form of adaptability. This study aims to examine the mediating role of innovation on the relationship between price and service quality to predict consumer satisfaction. The sample used as many as 160 with quota sampling technique. Path analysis was selected using the help of the Eviews v10 program, the indirect effect was carried out with the Sobel test. The findings of structural analysis I, show that price and service quality have a significant positive effect on innovation both individually and simultaneously. The results of structural analysis II, show that service quality directly has a significant positive effect on consumer satisfaction, while price directly has a significant negative effect on customer satisfaction. From the Sobel test, it is known that there is a significant positive causal effect of price and service quality on consumer satisfaction with the mediating role of innovation. Other causal effects related to price, service quality, the role of innovation and customer satisfaction still need to be investigated and developed.
Element Analysis and Sustainable Development of Portuguese Architecture
Authors: Junxin  Song
Published: October 2022

This paper mainly analyzes the elements of Portuguese architecture. Finally, according to the results of field investigation and historical data analysis, some reference suggestions are put forward from the perspective of cultural heritage protection
The Effect of Capital Structure, Institutional Ownership, Liquidity, and Diversification Strategy on Financial Performance
Authors: Kurniawati Astria , Wahyuni Sri , Fitriati Azmi , Inayati Nur Isna
Published: October 2022

Financial performance is a determination to measure the success of a profit making enterprise. This study aims to examine the influence of capital structure, institutional ownership, liquidity ratios, and diversification strategies. The population in this study is industrial sector companies listed on the IDX for the 2019-2021 period. The sampling method is carried out by purposive sampling. So that 81 research samples were obtained. The data analysis mthod used is multiple linear regression analysis.  The results of the partial analysis of capital structure, institutional ownership, and liquidity ratios have a significant negative effect on financial performance, while diversification strategies have a significant positive effect on financial performance. The results of this study can contribute scientifically to further research on factors that affect wishful performance.
Perancangan Sistem Administrasi Kantor Desa Mekarsari, Kabupaten Bandung
Authors: Sutisna Mamun , Amalia Sholihati , Tjahjawati Sri Surjani Tjahjawati , Sarah Ira Siti , Putri Ivon Sandya Sari , Suhaeni Tintin
Published: October 2022

Pemerintahan Desa Mekarsari, Kecamatan Pasirjambu, Kabupaten Bandung tidak mempunyai sistem pengelolaan dokumen pelayanan masyarakat yang baik sehingga berdampak pada kualitas pelayanan masyarakat. Upaya yang dilakukan untuk mengatasi hal tersebut adalah dengan memberikan pelatihan tentang pengelolaan dokumen administrasi sehingga siap dikelola oleh software Image Ware Scan Manager (IWSM). Software ini memungkinkan pengelolaan dokumen dalam jumlah yang besar secara efisien dan proses indeks dokumen secara otomatis. Kegiatan dilaksanakan sejak bulan Mei sampai dengan September 2022. Sistem administrasi yang dihasilkan dari kegiatan ini berdampak positif bagi pekerjaan para perangkat desa sehingga pelayanan pada masyarakat dapat terlaksana dengan lebih tertib dan cepat.
Pengembangan Sumber Daya Manusia berbasis Kompetensi untuk Meningkatkan Kualitas Produksi Briket Arang Batok Kelapa pada Kelompok Usaha Sundil Sejahtera
Authors: Idrus Syech , Damayanti Si Luh Putu , Gede I Putu , BM Firman
Published: October 2022

Kegiatan ini bertujuan mengembangkan sumber daya manusia berbasis kompetensi melalui pelatihan dan penambahan alat kerja guna meningkatkan kapsitas dan kualitas produksi briket arang batok kelapa. Sasaran dalam kegiatan PKM tahun 2022 adalah kelompok usaha Sundil Sejahtera dusun Sundil desa Montong Terep kabupaten Lombok Tengah. Metode pelaksanaan kegiatan berupa penyuluhan dan pendampingan. Hasil pre tes pengetahuan peserta terkait penjaminan mutu produk, merek, pengemasan, K3, dan pembukuan rata-rata diperoleh sebesar 47.13%, sedangkan nilai ketrampilannya 34.78%. Setelah kegiatan pengabdian dilakukan, terjadi peningkatan pengetahuan yaitu rata-rata sebanyak 88.53% dan keterampilannya rata-rata sebesar 80.95%, tumbuhnya kesadaran peserta atas pentingnya hal ini, ditandai dengan saran yang diterima tim pengabdiaan,  di mana seluruh peserta berharap agar kemitraan ini dapat diteruskan sebab manfaatnya sangat dirasakan.