bluuebunny/crossref_metadata_2025 huggingface dataset:
IMRT in oral cavity cancer
Authors: Studer Gabriela , Zwahlen Roger A , Graetz Klaus W , Davis Bernard J , Glanzmann Christoph
Published: May 2007

Background

Except for early T1,2 N0 stages, the prognosis for patients with oral cavity cancer (OCC) is reported to be worse than for carcinoma in other sites of the head and neck (HNC). The aim of this work was to assess disease outcome in OCC following IMRT.

Between January 2002 and January 2007, 346 HNC patients have been treated with curative intensity modulated radiation therapy (IMRT) at the Department of Radiation Oncology, University Hospital Zurich. Fifty eight of these (16%) were referred for postoperative (28) or definitive (30) radiation therapy of OCC.

40 of the 58 OCC patients (69%) presented with locally advanced T3/4 or recurred lesions. Doses between 60 and 70 Gy were applied, combined with simultaneous cisplatin based chemotherapy in 78%. Outcome analyses were performed using Kaplan Meier curves.

In addition, comparisons were performed between this IMRT OCC cohort and historic in-house cohorts of 33 conventionally irradiated (3DCRT) and 30 surgery only patients treated over the last 10 years.

Results

OCC patients treated with postoperative IMRT showed the highest local control (LC) rate of all assessed treatment sequence subgroups (92% LC at 2 years). Historic postoperative 3DCRT patients and patients treated with surgery alone reached LC rates of ~70–80%. Definitively irradiated patients revealed poorest LC rates with ~30 and 40% following 3DCRT and IMRT, respectively.

T1 stage resulted in an expectedly significantly higher LC rate (95%, n = 19, p < 0.05) than T2-4 and recurred stages (LC ~50–60%, n = 102).

Analyses according to the diagnosis revealed significantly lower LC in OCC following definitive IMRT than that in pharyngeal tumors treated with definitive IMRT in the same time period (43% vs 82% at 2 years, p < 0.0001), while the LC rate of OCC following postoperative IMRT was as high as in pharyngeal tumors treated with postoperative IMRT (>90% at 2 years).

Conclusion

Postoperative IMRT of OCC resulted in the highest local control rate of the assessed treatment subgroups. In conclusion, generous indication for IMRT following surgical treatment is recommended in OCC cases with unfavourable features like tight surgical margin, nodal involvement, primary tumor stage >T1N0, or already recurred disease, respectively.

Loco-regional outcome of OCC following definitive IMRT remained unsatisfactory, comparable to that following definitive 3DCRT.
Transcriptional regulatory network discovery via multiple method integration: application to e. coli K12
Authors: Sun Jingjun , Tuncay Kagan , Haidar Alaa Abi , Ensman Lisa , Stanley Frank , Trelinski Michael , Ortoleva Peter
Published: May 2007

Transcriptional regulatory network (TRN) discovery from one method (e.g. microarray analysis, gene ontology, phylogenic similarity) does not seem feasible due to lack of sufficient information, resulting in the construction of spurious or incomplete TRNs. We develop a methodology, TRND, that integrates a preliminary TRN, microarray data, gene ontology and phylogenic similarity to accurately discover TRNs and apply the method to E. coli K12. The approach can easily be extended to include other methodologies. Although gene ontology and phylogenic similarity have been used in the context of gene-gene networks, we show that more information can be extracted when gene-gene scores are transformed to gene-transcription factor (TF) scores using a preliminary TRN. This seems to be preferable over the construction of gene-gene interaction networks in light of the observed fact that gene expression and activity of a TF made of a component encoded by that gene is often out of phase. TRND multi-method integration is found to be facilitated by the use of a Bayesian framework for each method derived from its individual scoring measure and a training set of gene/TF regulatory interactions. The TRNs we construct are in better agreement with microarray data. The number of gene/TF interactions we discover is actually double that of existing networks.
Distal thoracic oesophageal perforation secondary to blunt trauma: Case report
Authors: Strauss Dirk C , Tandon Ruchi , Mason Robert C
Published: May 2007

Background

Traumatic perforation of the distal oesophagus due to blunt trauma is a very rare condition and is still associated with a significant morbidity and mortality. This is further exacerbated by delayed diagnosis and management as symptoms and signs are often masked by or ascribed to more common blunt thoracic injuries.

Case report

We present a case of a distal oesophageal perforation, secondary to a fall from a third storey window, which was masked by concomitant thoracic injuries and missed on both computed tomography imaging and laparotomy. The delay in his diagnosis significantly worsened the patient's recovery by allowing the development of an overwhelming chest sepsis that contributed to his death.

Conclusion

Early identification of an intrathoracic oesophageal perforation requires deliberate consideration and is essential to ensure a favorable outcome. Treatment should be individualised taking into account the nature of the oesophageal defect, time elapsed from injury and the patient's general condition.
Duhuo Jisheng Tang for treating osteoarthritis of the knee: a prospective clinical observation
Authors: Lai Jung-Nien , Chen Huey-Jeng , Chen Chao-Chung , Lin Jer-Huei , Hwang Jing-Shiang , Wang Jung-Der
Published: May 2007

Background

Little scientific evidence supports the efficacy of herbal medicines in the treatment of degenerative arthritis of the knee. The purpose of this study is to evaluate both the efficacy and safety of a finished Chinese herbal preparation Duhuo Jisheng Tang (DJT) in reducing symptoms of degenerative osteoarthritis of the knee.

Methods

A prospective follow-up study was carried out in two hospitals in Taipei between April and October 2005. Sixty-eight osteoarthritis patients, with symptoms diagnosed by radiologists, received DJT at a rate of 2.5 g, twice daily for four weeks. Baseline scores were measured on the Western Ontario and McMaster Universities Osteoarthritis (WOMAC) index, followed by further measures at the end of weeks 1, 2 and 4. The World Health Organization Quality of Life (WHOQOL) assessment was undertaken as a secondary outcome, with pattern identification questionnaires being adopted. Regression models were constructed to explore the score differences between the baseline and at weeks 2 and 4 by various determinants including age, gender, body mass index (BMI), severity at baseline, use of rescue medication, aversion to cold and flaccidity of the lower back and knees.

Results

Among the 68 participants, there were statistically significant reductions in the WOMAC index scores for pain, stiffness and physical functioning in the second and fourth weeks, with effects first appearing during week 2. By week 4, the mean WOMAC index scores had fallen from 22.2 (± 19.2) to 16.1 (± 16.2) for pain, from 28.1 (± 24.9) to 18.5 (± 20.3) for stiffness, and from 22.6 (± 18.0) to 18.2 (± 17.8) for physical functioning, while the global score for pain under the visual analogue scale (VAS) was reduced from 38.7 (± 21.5) to 27.8 (± 19.8).

Conclusion

In the treatment of degenerative osteoarthritis of the knee, a 4-week therapy with the Chinese herbal preparation DJT reduced pain and stiffness and improved physical functioning, but it was less effective in treating flaccidity and aversion to cold.
Cirrhotic cardiomyopathy
Authors: Baik Soon Koo , Fouad Tamer R , Lee Samuel S
Published: May 2007

Cirrhotic cardiomyopathy is the term used to describe a constellation of features indicative of abnormal heart structure and function in patients with cirrhosis. These include systolic and diastolic dysfunction, electrophysiological changes, and macroscopic and microscopic structural changes. The prevalence of cirrhotic cardiomyopathy remains unknown at present, mostly because the disease is generally latent and shows itself when the patient is subjected to stress such as exercise, drugs, hemorrhage and surgery. The main clinical features of cirrhotic cardiomyopathy include baseline increased cardiac output, attenuated systolic contraction or diastolic relaxation in response to physiologic, pharmacologic and surgical stress, and electrical conductance abnormalities (prolonged QT interval). In the majority of cases, diastolic dysfunction precedes systolic dysfunction, which tends to manifest only under conditions of stress. Generally, cirrhotic cardiomyopathy with overt severe heart failure is rare. Major stresses on the cardiovascular system such as liver transplantation, infections and insertion of transjugular intrahepatic portosystemic stent-shunts (TIPS) can unmask the presence of cirrhotic cardiomyopathy and thereby convert latent to overt heart failure. Cirrhotic cardiomyopathy may also contribute to the pathogenesis of hepatorenal syndrome. Pathogenic mechanisms of cirrhotic cardiomyopathy are multiple and include abnormal membrane biophysical characteristics, impaired β-adrenergic receptor signal transduction and increased activity of negative-inotropic pathways mediated by cGMP. Diagnosis and differential diagnosis require a careful assessment of patient history probing for excessive alcohol, physical examination for signs of hypertension such as retinal vascular changes, and appropriate diagnostic tests such as exercise stress electrocardiography, nuclear heart scans and coronary angiography. Current management recommendations include empirical, nonspecific and mainly supportive measures. The exact prognosis remains unclear. The extent of cirrhotic cardiomyopathy generally correlates to the degree of liver insufficiency. Reversibility is possible (either pharmacological or after liver transplantation), but further studies are needed.
Differential expression of interferon responsive genes in rodent models of transmissible spongiform encephalopathy disease
Authors: Stobart Michael J , Parchaliuk Debra , Simon Sharon LR , LeMaistre Jillian , Lazar Jozef , Rubenstein Richard , Knox J David
Published: May 2007

Background

The pathological hallmarks of transmissible spongiform encephalopathy (TSE) diseases are the deposition of a misfolded form of a host-encoded protein (PrPres), marked astrocytosis, microglial activation and spongiosis. The development of powerful gene based technologies has permitted increased levels of pro-inflammatory cytokines to be demonstrated. However, due to the use of assays of differing sensitivities and typically the analysis of a single model system it remained unclear whether this was a general feature of these diseases or to what extent different model systems and routes of infection influenced the relative levels of expression. Similarly, it was not clear whether the elevated levels of cytokines observed in the brain were accompanied by similar increases in other tissues that accumulate PrPres, such as the spleen.

Results

The level of expression of the three interferon responsive genes, Eif2ak2, 2'5'-OAS, and Mx2, was measured in the brains of Syrian hamsters infected with scrapie 263K, VM mice infected with bovine spongiform encephalopathy and C57BL/6 mice infected with the scrapie strain ME7. Glial fibrillary acidic expression confirmed the occurrence of astrocytosis in all models. When infected intracranially all three models showed a similar pattern of increased expression of the interferon responsive genes at the onset of clinical symptoms. At the terminal stage of the disease the level and pattern of expression of the three genes was mostly unchanged in the mouse models. In contrast, in hamsters infected by either the intracranial or intraperitoneal routes, both the level of expression and the expression of the three genes relative to one another was altered. Increased interferon responsive gene expression was not observed in a transgenic mouse model of Alzheimer's disease or the spleens of C57BL/6 mice infected with ME7. Concurrent increases in TNFα, TNFR1, Fas/ApoI receptor, and caspase 8 expression in ME7 infected C57BL/6 mice were observed.

Conclusion

The identification of increased interferon responsive gene expression in the brains of three rodent models of TSE disease at two different stages of disease progression suggest that this may be a general feature of the disease in rodents. In addition, it was determined that the increased interferon responsive gene expression was confined to the CNS and that the TSE model system and the route of infection influenced the pattern and extent of the increased expression. The concurrent increase in initiators of Eif2ak2 mediated apoptotic pathways in C57BL/6 mice infected with ME7 suggested one mechanism by which increased interferon responsive gene expression may enhance disease progression.
Lack of α-synuclein increases amyloid plaque accumulation in a transgenic mouse model of Alzheimer's disease
Authors: Kallhoff Verena , Peethumnongsin Erica , Zheng Hui
Published: May 2007

α-synuclein is a small soluble, cytosolic protein which associates with vesicular membranes. It is a component of intracellular Lewy bodies present in Parkinson's disease and a subset of Alzheimer's disease (AD). In addition, early studies identified a fragment of α-synuclein in the amyloid plaques of AD patients. Hypothesizing that α-synuclein might modify the AD pathogenic process, we crossed the Tg2576 strain of APP transgenic mice onto an α-synuclein knockout background to determine the effects of α-synuclein on Aβ production and plaque deposition. We found that α-synuclein deficiency does not affect the Aβ levels, nor does it alter the age of onset of plaque pathology. To our surprise, however, loss of α-synuclein leads to a significant increase in plaque load in all areas of the forebrain at 18 months of age. This is associated with an increase in another synaptic protein, synaptophysin. We thus conclude that α-synuclein is not involved in seeding of the plaques, but rather suppresses the progression of plaque pathology at advanced stages.
Apolipoprotein E levels in cerebrospinal fluid and the effects of ABCA1polymorphisms
Authors: Wahrle Suzanne E , Shah Aarti R , Fagan Anne M , Smemo Scott , Kauwe John SK , Grupe Andrew , Hinrichs Anthony , Mayo Kevin , Jiang Hong , Thal Leon J , Goate Alison M , Holtzman David M
Published: May 2007

Background

Animal studies suggest that brain apolipoprotein E (apoE) levels influence amyloid-β (Aβ) deposition and thus risk for Alzheimer's disease (AD). We have previously demonstrated that deletion of the ATP-binding cassette A1 transporter (ABCA1) in mice causes dramatic reductions in brain and cerebrospinal fluid (CSF) apoE levels and lipidation. To examine whether polymorphisms in ABCA1 affect CSF apoE levels in humans, we measured apoE in CSF taken from 168 subjects who were 43 to 91 years old and were either cognitively normal or who had mild AD. We then genotyped the subjects for ten previously identified ABCA1 single nucleotide polymorphisms (SNPs).

Results

In all subjects, the mean CSF apoE level was 9.09 μg/ml with a standard deviation of 2.70 μg/ml. Levels of apoE in CSF samples taken from the same individual two weeks apart were strongly correlated (r2 = 0.93, p < 0.01). In contrast, CSF apoE levels in different individuals varied widely (coefficient of variation = 46%). CSF apoE levels did not vary according to AD status, APOE genotype, gender or race. Average apoE levels increased with age by ~0.5 μg/ml per 10 years (r2 = 0.05, p = 0.003). We found no significant associations between CSF apoE levels and the ten ABCA1 SNPs we genotyped. Moreover, in a separate sample of 1225 AD cases and 1431 controls, we found no association between the ABCA1 SNP rs2230806 and AD as has been previously reported.

Conclusion

We found that CSF apoE levels vary widely between individuals, but are stable within individuals over a two-week interval. AD status, APOE genotype, gender and race do not affect CSF apoE levels, but average CSF apoE levels increase with age. Given the lack of association between CSF apoE levels and genotypes for the ABCA1 SNPs we examined, either these SNPs do not affect ABCA1 function or if they do, they do not have strong effects in the CNS. Finally, we find no evidence for an association between the ABCA1 SNP rs2230806 and AD in a large sample set.
Caries in the infundibulum of the second upper premolar tooth in the horse
Authors: Lundström Torbjörn S , Dahlén Gunnar G , Wattle Ove S
Published: May 2007

Background

Swedish equine dental practices have empirically found that the prevalence of infundibular caries as a primary disorder in the first permanent premolar teeth (P2) of the horse upper jaw has increased during the last 10 years. A previously unknown bacterial species, Streptococcus devriesei (CCUG 47155T), which is related to Streptococcus mutans, has recently been isolated from these carious lesions. To understand the aetiology of caries in horses, it is essential to elucidate the relationship between S. devriesei and P2 infundibular caries.

Methods

The anterior infundibulum of maxillary P2, or the occlusal surface at the site of the infundibulum, in 117 horses and ponies, 77 with and 40 without caries in this tooth, was sampled for bacteriological analyses between 1990 and 2004. Samples were transported in VMGA III medium and then inoculated onto MSB agar. The approximate number of bacteria was counted in each sample and the isolates were characterised biochemically, using a commercial kit.

Results

All 50 samples taken from carious lesions after 2002 were positive for an S. mutans-like strain, i.e. S. devriesei. The bacteria were also found in four of the control animals, but were much less numerous than in samples from caries-affected horses. None of the swabs taken prior to 2002 were positive for this bacteria.

Conclusion

Our results demonstrate that S. devriesei can colonise the infundibulum of P2 of the horse upper jaw, which can be fatal for the dental tissue. We conclude that S. devriesei is strongly associated with P2 caries in horses.
HitKeeper, a generic software package for hit list management
Authors: Hau Jörg , Muller Michael , Pagni Marco
Published: May 2007

Background

The automated annotation of biological sequences (protein, DNA) relies on the computation of hits (predicted features) on the sequences using various algorithms. Public databases of biological sequences provide a wealth of biological "knowledge", for example manually validated annotations (features) that are located on the sequences, but mining the sequence annotations and especially the predicted and curated features requires dedicated tools. Due to the heterogeneity and diversity of the biological information, it is difficult to handle redundancy, frequent updates, taxonomic information and "private" data together with computational algorithms in a common workflow.

Results

We present HitKeeper, a software package that controls the fully automatic handling of multiple biological databases and of hit list calculations on a large scale. The software implements an asynchronous update system that introduces updates and computes hits as soon as new data become available. A query interface enables the user to search sequences by specifying constraints, such as retrieving sequences that contain specific motifs, or a defined arrangement of motifs ("metamotifs"), or filtering based on the taxonomic classification of a sequence.

Conclusion

The software provides a generic and modular framework to handle the redundancy and incremental updates of biological databases, and an original query language. It is published under the terms and conditions of version 2 of the GNU Public License and available at http://hitkeeper.sourceforge.net.
Effect of carbon source perturbations on transcriptional regulation of metabolic fluxes in Saccharomyces cerevisiae
Authors: Çakır Tunahan , Kırdar Betül , Önsan Zİlsen , Ülgen Kutlu Ö , Nielsen Jens
Published: May 2007

Background

Control effective flux (CEF) of a reaction is the weighted sum of all fluxes through that reaction, derived from elementary flux modes (EFM) of a metabolic network. Change in CEFs under different environmental conditions has earlier been proven to be correlated with the corresponding changes in the transcriptome. Here we use this to investigate the degree of transcriptional regulation of fluxes in the metabolism of Saccharomyces cerevisiae. We do this by quantifying correlations between changes in CEFs and changes in transcript levels for shifts in carbon source, i.e. between the fermentative carbon source glucose and nonfermentative carbon sources like ethanol, acetate, and lactate. The CEF analysis is based on a simple stoichiometric model that includes reactions of the central carbon metabolism and the amino acid metabolism.

Results

The effect of the carbon shift on the metabolic fluxes was investigated for both batch and chemostat cultures. For growth on glucose in batch (respiro-fermentative) cultures, EFMs with no by-product formation were removed from the analysis of the CEFs, whereas those including any by-products (ethanol, glycerol, acetate, succinate) were omitted in the analysis of growth on glucose in chemostat (respiratory) cultures. This resulted in improved correlations between CEF changes and transcript levels. A regression correlation coefficient of 0.60 was obtained between CEF changes and gene expression changes in the central carbon metabolism for the analysis of 5 different perturbations. Out of 45 data points there were no more than 6 data points deviating from the correlation. Additionally, up- or down-regulation of at least 75% of the genes were in qualitative agreement with the CEF changes for all perturbations studied.

Conclusion

The analysis indicates that changes in carbon source are associated with a high degree of hierarchical regulation of metabolic fluxes in the central carbon metabolism as the change in fluxes are correlating directly with the change in transcript levels of genes encoding their corresponding enzymes. For amino acid biosynthesis there was, however, not found to exist a similar correlation, and this may point to either post-transcriptional and/or metabolic regulation, or be due to the absence of a direct perturbation on the amino acid pathways in these experiments.
Toll-Like Receptor 9 Expression in Murine and Human Adrenal Glands and Possible Implications during Inflammation
Authors: Tran Nguyen , Koch Alexander , Berkels Reinhard , Boehm Olaf , Zacharowski Paula A. , Baumgarten Georg , Knuefermann Pascal , Schott Matthias , Kanczkowski Waldemar , Bornstein Stefan R. , Lightman Stafford L. , Zacharowski Kai
Published: May 2007

Context: Sepsis is a leading cause of death in the Western world and can be associated with failure of the hypothalamic-pituitary-adrenal axis. A coordinated response of the adrenal and immune system is of vital importance for survival during sepsis. Within the immune response, Toll-like receptors (TLRs) play a crucial role by recognizing pathogen-associated molecules such as bacterial DNA. TLR-9 can detect motifs of unmethylated cytosine-phosphate-guanine (CpG) dinucleotides (CpG-DNA) being present in bacterial DNA.

Objective: We investigated whether TLR-9 is expressed in human and murine adrenal glands and whether its activation is associated with an adrenal response.

Design: Human fetal and adult adrenal glands; wild-type, C57BL/6 and TLR-9 deficient (TLR-9−/−) mice; and in vitro cell line models were used in the study.

Setting: The study took place at a university hospital.

Results: TLR-9 is expressed in human and murine adrenal glands, as well as in in vitro cell lines (Y-1 and NCI-H295R cells). CpG-oligodeoxynucleotide challenge caused a 3-fold increase in plasma levels of corticosterone in wild-type mice. This effect was not observed in TLR-9−/− mice. Furthermore, CpG-oligodeoxynucleotide challenge resulted in a strong release of several inflammatory cytokines, such as TNF-α, and IL-1β, -6, -10, and -12 in vivo as well as in vitro. Again, this effect was not present in TLR-9−/− mice.

Conclusions: TLR-9 is present in both murine and human adrenal glands. TLR-9 stimulation led to a corticosterone and inflammatory cytokine response. TLR-9 may play a role in the regulation of the hypothalamic-pituitary-adrenal axis during conditions in which bacterial DNA is present.
Defining the LGR8 Residues Involved in Binding Insulin-Like Peptide 3
Authors: Scott Daniel J. , Wilkinson Tracey N. , Zhang Suode , Ferraro Tania , Wade John D. , Tregear Geoffrey W. , Bathgate Ross A. D.
Published: May 2007

The peptide hormone insulin-like peptide 3 (INSL3) is essential for testicular descent and has been implicated in the control of adult fertility in both sexes. The human INSL3 receptor leucine-rich repeat-containing G protein-coupled receptor 8 (LGR8) binds INSL3 and relaxin with high affinity, whereas the relaxin receptor LGR7 only binds relaxin. LGR7 and LGR8 bind their ligands within the 10 leucine-rich repeats (LRRs) that comprise the majority of their ectodomains. To define the primary INSL3 binding site in LGR8, its LRRs were first modeled on the crystal structure of the Nogo receptor (NgR) and the most likely binding surface identified. Multiple sequence alignment of this surface revealed the presence of seven of the nine residues implicated in relaxin binding to LGR7. Replacement of these residues with alanine caused reduced [125I]INSL3 binding, and a specific peptide/receptor interaction point was revealed using competition binding assays with mutant INSL3 peptides. This point was used to crudely dock the solution structure of INSL3 onto the LRR model of LGR8, allowing the prediction of the INSL3 Trp-B27 binding site. This prediction was then validated using mutant INSL3 peptide competition binding assays on LGR8 mutants. Our results indicated that LGR8 Asp-227 was crucial for binding INSL3 Arg-B16, whereas LGR8 Phe-131 and Gln-133 were involved in INSL3 Trp-B27 binding. From these two defined interactions, we predicted the complete INSL3/LGR8 primary binding site, including interactions between INSL3 His-B12 and LGR8 Trp-177, INSL3 Val-B19 and LGR8 Ile-179, and INSL3 Arg-B20 with LGR8 Asp-181 and Glu-229.
The role of achievement goal orientations in students' perceptions of and preferences for classroom environment
Authors: Tapola Anna. , Niemivirta Markku.
Published: May 2007

Background. Recent research on achievement motivation has begun to examine the effects of environmental factors affecting students' motivational beliefs and goal tendencies. However, when interpreting and applying the results, individual factors underlying students' different perceptions of their learning environment are often ignored. An implicit assumption seems to be that regardless of their dispositional differences (e.g. motivational basis), students will experience and benefit from instructional practices in the same way.

Aims. This paper highlights the importance of students' dispositional motivational factors when examining differences in their perceptions of and preferences for the learning environment. The study builds on a conception of student motivation that emphasizes the interaction of individual and contextual factors.

Sample and method. Questionnaires served as self‐report tools and assessed students' achievement goal orientations, self‐esteem, causality beliefs, academic withdrawal and perceptions of and preferences for the learning environment. The sample consisted of 208 sixth grade elementary school students.

Results. Based on latent class cluster analysis and one‐way analyses of variance, it was found that students' perceptions of and preferences for the learning environment vary depending on differences in students' motivational tendencies.

Conclusions. Students' dispositional motivational characteristics should be taken into account both in theoretical considerations and in instructional interventions.
Which thoughts can kill a boxer? Naive theories about cognitive and emotional antecedents of suicide
Authors: Spörrle Matthias , Försterling Friedrich
Published: May 2007

Objectives. We investigated naive theories regarding the association among beliefs, emotions and behaviours to test Rational Emotive Behaviour Therapy's (REBT) assumption that rational cognitions and adaptive emotions lead to functional behaviours whereas irrational cognitions and maladaptive emotions trigger dysfunctional reactions.

Design. We applied an experimental between‐subjects design.

Methods. Participants read newspaper articles about the defeat of a boxer. In one condition, the authentic article informed participants that he committed suicide and in the other, a fictitious article about the same defeat described the athlete as successfully continuing his career. Different question formats were employed to assess participants' assumptions about the stimulus person's defeat‐related cognitions and emotions: rating scales, sentence completion and free responses.

Results. Participants assumed significantly more irrational beliefs (e.g. ‘I absolutely have to win’) on the side of the boxer in the suicide scenario than in the non‐suicide version. This finding was obtained by directive and non‐directive assessment methods. Additionally, participants expected the suicidal stimulus person to be experiencing maladaptive emotions (e.g. depression, guilt) whereas a successful resumption of his career lead to expectations of adaptive affects (e.g. sadness, concern). Ratings of the functionality revealed that sadness, fear, annoyance and concern were expected to be more functional than depression, anxiety, rage and guilt.

Conclusions. The results show that naive psychological theories about the antecedents of dysfunctional behaviour are in accordance with theoretical assumptions of REBT: Irrational beliefs are viewed to be connected with maladaptive emotions and to result in dysfunctional behaviour, and adaptive emotions are thought to be of higher functional value than their maladaptive counterparts. The use of different question formats and a between‐subject design excluded that results are due to methodological artifacts or contrast effects.
An Exploration of Recent Club Drug Use among Rave Attendees
Authors: Yacoubian George S. , Peters Ronald J.
Published: May 2007

Raves are characterized by large numbers of youth dancing for long periods of time and by the use of “club drugs,” such as 3, 4-methylenedioxymethamphetamine (MDMA or “ecstasy”). While a small body of research has explored the use of ecstasy and other club drugs (EOCD) among club rave attendees in the United States, we are aware of no studies that have investigated the relationship between EOCD use and high-risk sexual behaviors among members of this population. We explored the association between EOCD use and high-risk sexual behaviors among a sample of 283 club rave attendees interviewed during the spring and summer of 2005. Data were collected at 13 rave events in two different clubs along the Baltimore-Washington corridor between March 17 and September 3, 2005. Potential respondents were conveniently sampled and approached between 12 a.m. and 5 a.m. as they exited the clubs. Only 12% reported using ecstasy within the two days preceding the interview, findings considerably lower than our earlier studies of club rave attendees. Moreover, no significant relationship was discerned between recent MDMA use and high-risk sexual behavior. These findings suggest that the use of EOCD among rave attendees has diminished and that the allocation of significant resources to combat their proliferation, among this and other populations at risk for EOCD use, may be premature.
Predicting Successful College Experiences: Evidence from a First Year Retention Program
Authors: Noble Kimberly , Flynn Nicole T. , Lee James D. , Hilton David
Published: May 2007

Research indicates that programs designed to target first year students increase their likelihood of success during that year and their chances of completing an undergraduate education (Bureau & Rromrey, 1994; Conner & Colton, 1999). Theoretically, such programs should help in part because they foster integration into campus communities and help align personal goals with institutional goals. In an effort to increase retention and achievement of first year students, the University of South Alabama implemented a program for resident first year students called ESSENCE in the fall of 1998. The purpose of this study is to measure the effects of that program on student success. Specifically we are interested in assessing the effects of the program on GPAs and graduation rates. In multivariate analyses, we compare GPAs and graduation rates for resident ESSENCE students, resident non-ESSENCE students, and non-resident students controlling for other predictors of success. We find that ESSENCE improves GPAs and the likelihood of graduating in five years relative to other experiences, even when controlling for other factors.
Differences by Gender, Ethnicity, and Acculturation in the Efficacy of the keepin’ it Real Model Prevention Program
Authors: Kulis Stephen , Yabiku Scott T. , Marsiglia Flavio F. , Nieri Tanya , Crossman Ashley
Published: May 2007

This study examined whether the efficacy of keepin’ it REAL, a model program for substance use prevention in schools, was moderated by gender, ethnicity, and acculturation. Gender differences in program efficacy may arise through boys' higher risk of drug use, inadequate attention to girls' developmental issues, or cultural factors like polarized gender expectations. Data came from a randomized trial in 35 Phoenix, Arizona, middle schools involving 4,622 mostly Latino 7th graders. Using multi-level mixed models and multiple imputation missing techniques, results for the total sample showed no gender differences in program effects on recent substance use, but the program was more effective in fostering boys' than girls' anti-drug norms. Subgroup analyses demonstrated several more beneficial program effects for boys than girls (less alcohol and cigarette use and stronger anti-drug norms), but only among less acculturated Latinos. There were no gender differences in program effects among more acculturated Latinos, nor among non-Latino whites.
The Professional Mentor Program Plus: An Academic Success and Retention Tool for Adult Learners
Authors: Scott Chaunda L. , Homant Robert J.
Published: May 2007

To promote the academic success of and to retain adult students of color, the Academic Services Unit at the University of Detroit Mercy (UDM), an urban Catholic university, in Detroit Michigan, has designed and implemented the Professional Mentor Program Plus, funded by the State of Michigan's King-Chavez-Parks (KCP) higher education initiative, that fuses academic support programming, and mentoring, designed exclusively for adult students, into a proactive academic success and retention model. The program's rationale, history, and findings from the 2003–04 year-end evaluation are presented, followed by the program's future development plan.
Utilizing First-Year Curricula Linkage to Improve In-Major Persistence to Graduation: Results from a Four-Year Longitudinal Study, Fall 2000—Spring 2004
Authors: Lifton Donald , Cohen Alan , Schlesinger Warren
Published: May 2007

Academic departments have expanded the typical persistence agenda of First-Year Seminars to use them specifically as tools for in-major retention. This article reports the empirical results of a four-year longitudinal study assessing the successful efforts to improve the persistence-to-graduation-within-major of business students. The pedagogy can be easily transferred to other campus majors. The approach used in this study linked a discipline-specific First-Year Seminar in business with the curriculum of an existing “traditional” business course, Introduction to Business. The study's results suggest that, in the first semester, a curriculum linkage between a First-Year Seminar and a traditional course in the same discipline may be an antidote to the lure that other disciplines have in swaying new students away from their original choice of major.
Great Minds Don't Always Think Alike: The Challenges of Conducting Substance Abuse Prevention Research in Public Schools
Authors: Renes Susan L. , Ringwalt Chris , Clark Heddy Kovach , Hanley Sean
Published: May 2007

Prevention researchers and school personnel lack a common understanding concerning the opportunities and burdens of school-based drug prevention research. In this article, we review issues related to researching substance abuse prevention programs in school settings, and assess challenges related to recruitment, communication, research design, surveying, and ensuring program fidelity. We conclude that before any school is enrolled, there must be a mutual understanding as to the nature and extent of the study's requirements and what adjustments a school will have to make to support a successful collaboration. Further, researchers must understand that schools' responsibilities for preparing students to perform well on academic and standardized tests will always overshadow the value they place on participating in studies to evaluate the effectiveness of prevention curricula.
Tenacious Persisters: Returning Adult Students in Higher Education
Authors: Kinser Kevin , Deitchman Jay
Published: May 2007

We identify “tenacious persisters” as returning students who have stopped out of college or who delayed their entry into college for more than three years after high school. Using a mixed method approach, we compare the experiences of tenacious persisters enrolled in a community college to students who followed more standard persistence paths. Both groups have similar motivations for attending college at this point in their lives, and similar expectations for achieving their goals. Tenacious persisters, however, attribute much more significance to barriers and personal deficiencies in explaining their past attendance patterns. We conclude that how students persist either as tenacious persisters or standard persisters seems to make a difference in how they view their current attempt at college and the obstacles they may have overcome to be there.
Revisiting First-Year College Students' Mattering: Social Support, Academic Stress, and the Mattering Experience
Authors: Rayle Andrea Dixon , Chung Kuo-Yi
Published: May 2007

In this study, Nancy Schlossberg's (1989) theory of college students' mattering to others was revisited. Mattering is the experience of others depending on us, being interested in us, and being concerned with our fate. The relationships of gender, mattering to college friends and the college environment, and friend and family social support with academic stress of 533 first-year undergraduates were examined. Female students reported higher levels of family support, mattering to friends, mattering to their college, and academic stress. Regardless of gender, college friend social support was the most powerful predictor of mattering; mattering to the college was the most powerful predictor of academic stress levels. Research-informed implications for reducing first-year students' academic stress and enforcing their social support and experiences of mattering are discussed.
Contact angles of protein black foam films under dynamic and equilibrium conditions
Authors: Nedyalkov Michail , Sultanem Caroline , Benattar Jean-Jacque
Published: May 2007

The contact angles of protein Newton black foam films from ALG (alpha-lactalbumin), BLG (beta-lactoglobulin) and BSA (bovine serum albumin) are measured here within. The measurements are carried out under dynamic and equilibrium conditions. For all proteins, a strong hystheresis effect of the contact angle is observed under dynamic conditions. An attempt is made to explain these results by the slow adsorption and desorption kinetics of the protein bilayers and by the dynamic structure and the rheology of the protein network forming the bubble walls. In addition, we propose a modification of the experimental device reported previously for contact angle measurements of large flat films in equilibrium. The advantages of this method are discussed in detail. Some shortcomings (precision, reproducibility) of this preliminary variant of the device in this initial stage of its application, do not allow one to draw reliable conclusions about the interactions of these films. Some improvements of the measurement quality are proposed.
Determination of diclofenac in pharmaceuticals and urine samples using a membrane sensor based on the ion associate of diclofenac with Rhodamine B
Authors: Kormosh Zholt , Hunka Iryna , Bazel Yaroslav , Laganovsky Andriy , Mazurenko Iryna , Kormosh Nataliya
Published: May 2007

The potentiometric response characteristics of a diclofenac selective electrode, based on ion association in different plasticizers, were compared. The sensitivity, working range, detection limit and selectivity of membrane sensors demonstrated significant dependence on the type of plasticizers. The potentiometric unit presented a linear response toward diclofenac concentrations between 1 × 10−5 − 5 × 10−2 mol L−1, with slopes of approximately 60 mV dec−1, and exhibited a response time of 3 s. The potentiometric analysis of sodium diclofenac in pharmaceutical formulations was perfomed by the membrane electrode proposed and compared with the results of potentiometric titration given by the Pharmacopoeia of Ukraine.
On formation of thin SiO2/a-Si:H interface when biased oxidized semiconductor surface interacts with plasma or liquid solution
Authors: Pinčík Emil , Kobayashi Hikaru , Takahashi Masao , Brunner Róbert , Jurečka Stanislav , Rusnák Jaroslav
Published: May 2007

In this paper we present the results of research into a relation(s) between the bias voltage of an oxide/a-Si:H/c-Si sample during formation of very-thin and thin oxides and the resulting distribution of oxide/semiconductor interface states in the a-Si:H band gap. Two oxygen plasma sources were used for the first time in our laboratories for formation of oxide layers on a-Si:H: i) inductively coupled plasma in connection with its application at plasma anodic oxidation; ii) rf plasma as the source of positive oxygen ions for the plasma immersion ion implantation process. The oxide growth on a-Si:H during plasma anodization is also simply described theoretically. Properties of plasmatic structures are compared to ones treated by chemical oxidation that uses 68 wt% nitric acid aqueous solutions. We have confirmed that three parameters of the oxide growth process — kinetic energy of interacting particles, UV-VIS-NIR light emitted by plasma sources, and bias of the samples — determine the distribution of defect states at both the oxide/a-Si:H interface and the volume of the a-Si:H layer, respectively. Additionally, a bias of the sample applied during the oxide growth process has a similar impact on the distribution of defect states as it can be observed during the bias-annealing of similar MOS structure outside of the plasma reactor.
Role of the mercury pressure during reaction synthesis of Hg(Re)-based superconducting films
Authors: Valeriánová M. , Chromik Š. , Odier P. , Štrbík V.
Published: May 2007

Thin films of mercury based superconductors were prepared on the R-plane sapphire with a CeO2 buffer layer using a two step process involving the deposition of the Hg-free precursor and ex situ mercuration in the sealed quartz tube. For the thin film preparation, a method with no contact between the mercury source and the precursor film was used for mercuration. We studied the influence of the basic parameters of the mercuration (annealing time, temperature and partial pressure of the mercury) regarding the composition and superconducting properties of prepared Hg-based films to determine appropriate conditions for this mercuration method. We found out that an increased partial pressure of mercury inhibited the creation of the parasitic Re-based phase and supported the crystallization of the superconducting phase. The advantage of this mercuration method is higher reproducibility as well as its capability to prepare high quality thin large areas films.
Helminths of the vagrant shrew, Sorex vagrans, from western Montana, USA
Authors: Kinsella John
Published: May 2007

A total of 19 helminth species (1 trematode, 11 cestodes, 7 nematodes) were collected from 45 vagrant shrews, Sorex vagrans (Mammalia, Soricidae), in western Montana, USA. One trematode (Brachylaima sp.), 2 cestodes (Paruterina candelabraria, Staphylocystoides longi), and 6 nematodes (Baruscapillaria rauschi, Eucoleus oesophagicola, Longistriata meylani, Paracrenosoma sp., Parastrongyloides winchesi, Pseudophysaloptera formosana) are reported for the first time from this host. Baruscapillaria rauschi n. comb. is proposed for Capillaria rauschi Read, 1949. This is the first record of merocercoids of P. candelabraria from a shrew, and the first report of the genus Paracrenosoma in North America.
Larval Hysterothylacium sp. (Nematoda, Anisakidae) and trematode metacercariae from the amphipod Paracorophium excavatum (Corphiidae) in New Zealand
Authors: Luque José , Bannock Liza , Lagrue Clément , Poulin Robert
Published: May 2007

Previously undescribed fourth-stage larvae of anisakid nematodes were found in the haemocoel of the amphipod Paracorophium excavatum (Thomson, 1884) (Corophiidae) in New Zealand. Morphological examination by light microscopy showed that the worms belonged to a species of Hysterothylacium Ward et Magath, 1917, based on several characters including the presence of interlabia, the location of the excretory pore posterior to the nerve ring, and the characteristics of the intestinal caecum and ventricular appendix. Interestingly, several male specimens showed precocious sexual development. This is the first record of fourth larval stage and precocious adult male specimens of Hysterothylacium in an invertebrate host, as well as the first record of anisakid larvae in New Zealand crustaceans. In addition, metacercariae of two trematode species, Coitocaecum parvum and Microphallus sp., are recorded for the first time from the amphipod P. excavatum.
Evaluation of the Ability of Physical Therapists to Palpate Intrapelvic Motion With the Stork Test on the Support Side
Authors: Hungerford Barbara A , Gilleard Wendy , Moran Michael , Emmerson Cathryn
Published: May 2007

Background and Purpose

Clinical indicators of pelvic girdle dysfunction are limited. However, research has shown that the pattern of intrapelvic motion is altered during single-leg support in subjects with pelvic girdle pain (PGP). Functionally, no relative motion should occur within the pelvis during load transfer, whereas anterior rotation of the innominate bone relative to the sacrum occurs during weight bearing in the presence of PGP. The aim of this study was to investigate whether the pattern of intrapelvic motion could be detected reliably during a new clinical assessment test for functional load transfer: the Stork Test on the support side.

Subjects and Methods

Three physical therapists were randomly assigned to palpate the motion of the innominate bones and sacrum in 33 subjects during the Stork Test on the support side. The direction of bone motion was indicated on 2-point and 3-point scales.

Results

When a 2-point scale was used, intertherapist agreement on the pattern of intrapelvic motion occurring during load transfer showed good reliability (left κ=.67, right κ=.77), and the percentage of agreement was high (left=91.9%, right=89.9%). A 3-point scale resulted in moderate reliability for both the left and the right sides (left κ=.59, right κ=.59), and the percentage of agreement decreased to 82.8% (left) and 79.8% (right).

Discussion and Conclusion

The ability of the physical therapists to reliably palpate and recognize an altered pattern of intrapelvic motion during the Stork Test on the support side was substantiated. The ability to distinguish between no relative movement and anterior rotation of the innominate bone during a load-bearing task was good. Further research is needed to determine the validity of this test for detecting pelvic girdle dysfunction.