bluuebunny/crossref_metadata_2025 huggingface dataset:
Ioannites - the course of the chiliastic-eschatological orientation of Orthodox origin
Authors: Shuhayeva Liudmyla M.
Published: December 2019

In the first decades of the XIX century. the territory of the Russian Empire from Western Europe is beginning to penetrate chiliastic ideas. The term "chiliism" refers to the well-known doctrine of the millennial kingdom of Icyca Christ on earth, dating to the first centuries of Christianity. The ideas of chilias became especially popular during the reign of Alexander I, who himself was sympathetic to the mystical-chiliatic teachings. Chilias in the Russian Empire spread in two ways. On the one hand, chiliastic ideas penetrated with the works of German mystics of the late eighteenth - early twentieth centuries. On the other hand, in anticipation of the fast approaching of the millennial kingdom of Christ, the German cultists of the Hiliists moved large parties across southern Russia to the Caucasus, thereby facilitating the spread of their ideas. The religious formations of the Orthodox sectarianism of the chiliastic-eschatological orientation are represented by the Jehovah-Hlinists ("Right Brotherhood"), the Ioannites, and the Malavans.
Summary
Authors: Of the Journal Editorial board
Published: December 2019

Summary
Table of Contents
Authors: Of the Journal Editorial board
Published: December 2019

Table of Contents
PENERAPAN TASK-TECHNOLOGY FIT TERHADAP KINERJA GURU SMK NEGERI 1 INDRALAYA SELATAN
Authors: Wardani Kiky Rizky nova
Published: December 2019

Tujuan dari penelitian ini adalah untuk mengetahui penerapan task-technology fit terhadap kinerja Guru Honor SMK Negeri 1 Indralaya Selatan. Penelitian ini menggunakan sampel sebanyak 52 responden. Metode pengumpulan data menggunakan kuesioner. Teknik analisis data yang digunakan adalah analisis regresi linear sederhana. Hasil dari penelitian ini dapat  memperjelas bahwa aspek teknologi, misalnya: kualitas sistem informasi yang baik akan memberikan motivasi terhadap pemakai sistem informasi (misalnya: berdasarkan kegunaan yang dirasakan). Hal ini tentu saja didukung dengan norma sosial dan faktor situasional lainnya. norma dan faktor ini tentunya  akan meningkatkan pemanfaatan pemakaian teknologi informasi yang membawa ke arah positif bagi kinerja. Untuk hasil dari nilai task-technology fit berpengaruh terhadap kinerja individual, hal ini terbukti dari nilai signifikansinya yang lebih kecil dari 5%. dari nilai tersebut dapat diketahui bahwa pengaruh task-technology fit terhadap kinerja individual dikategorikan baik
The protective effects of melatonin on organisms against the environmental pollutants of heavy metal and non-mental toxins
Authors: Xin Zhenlong , Zhang Xiaolu , Hu Wei , Tan Dunxian X , Han Mengzhen , Ji Ting , Jiang Shuai , Yu Zihao , Reiter Russel. J , Yang Yang
Published: December 2019

Metal and non-metal toxins are primarily derived from the human industrial and agricultural activities. These toxins have substantially polluted our ecosystem and become a major threatening factor to our health. Metal or non-metal pollutants are highly toxic because they interact with biological macromolecules including DNA, proteins and membrane to induce oxidative stress. If they are not properly handled, these toxins will inevitably cause organ and tissue injuries in both animals and plants. To identify the effective remedies to detoxify these toxins becomes the urgent agenda for researchers. Accumulated evidence indicates that melatonin may be a suitable molecule for this purpose. Melatonin, a naturally occurring antioxidant, directly scavenges ROS or upregulates expressions of many antioxidant enzymes to indirectly reduces ROS. In addition, it also promotes the excretion of these metal or non-metal toxins from the body. The multiple protective mechanisms of melatonin   effectively suppress the oxidative stress induced by the metal or non-metal toxins in animals or plants. Melatonin is an environmental-friendly molecule with low or none toxicity to animals or plants. It is a promising molecule which can be used to detoxify the environmental pollutants.
Daytime orexin and night-time melatonin regulation of mitochondria melatonin: roles in circadian oscillations systemically and centrally in breast cancer symptomatology
Authors: Anderson George
Published: December 2019

This article reviews the recent proposed model of Reiter and colleagues in this journal on the role of circadian, pineal gland-derived melatonin in driving mitochondria melatonin production in the pathoetiology and pathophysiology of breast cancers. This uptake of melatonin is proposed to inhibit pyruvate dehydrogenase kinase, thereby increasing the production of acetyl-CoA from pyruvate, with acetyl-CoA being a necessary co-factor for the initiation of the melatonergic pathway within mitochondria. Consequently, this proposed model suggests that a circadian shift in metabolic regulation occurs in breast cancers, from daytime cytosolic glycolysis to a night-time, melatonin-driven mitochondria oxidative phosphorylation, with relevance to the early pathoetiology of breast cancers. This has a number of consequences and links well to wider breast cancer data showing a pathophysiological role for the aryl hydrocarbon receptor, cytochrome P450 (CYP)1B1, 14-3-3 protein, and microRNAs. The current article overviews such data in the context of pineal gland-derived melatonin's circadian regulation of the mitochondria melatonergic pathways in breast cancer cells as proposed by Reiter and colleagues, suggesting that daytime, wake promoting orexin and stress-induced gut dysregulation contribute to mitochondria dysfunction in wider breast cancer symptomatology.
Constant light exposure terminates pregnancy in rats with pineal gland dysfunction, low melatonin level and pro-inflammatory response
Authors: Berbets Andrii M , Barbe Adrian M , Yuzko Oleksandr M
Published: December 2019

In the current study, the prolonged light exposure at night on the

function of pineal gland, melatonin production, pro-inflammatory response and progress of pregnancy in pregnant rats were

investigated. A long term (entire gestation stage) of 24 h light exposure not

only modify the morphologies of pinealocytes by decreasing their nucleus/cytoplasm ratio and mitochondrial

numbers but also reduce the level of circulating melatonin. The biological

consequences for this constant light exposure in pregnant rats were the

elevated the pro-inflammatory response indicated by the increased production of

IL-6 and finally, the termination of pregnancy compared to their controlled counterparts

under the normal light/dark cycle. The result showed that the pregnancy was

terminated at the early stage of embryo development. The report, for the first

time, established a potential association among the pineal function,

pro-inflammatory reaction and pregnant progress under the influence of light

exposure. This observation has a high relevant to the rise in human infertility since humans have overexposed to the light

at night with the increased light pollution globally.
Enterochromaffin cells as the source of melatonin: key findings and functional relevance in mammals
Authors: Pal Palash K. , Sarkar Swaimanti , Chattopadhyay Aindrila , Tan Dunxian X , Bandyopadhyay Debasish
Published: December 2019

The enteroendocrine cells in gastrointestinal (GI) tract synthesize more than thirty hormones in mammals. Among these cells, the enterochromaffin (EC) cells are probably the most important one due to the fact that they produce melatonin. The rate-limiting enzymes for melatonin synthesis including arylalkylamine-N-acetyltransferase (AANAT, currently the SNAT) and hydroxyindole-O-methyltransferase (HIOMT, currently the ASMT) have been identified in EC cells and this has confirmed the local melatonin production in GI tract by these cells. EC cells play a critical role in regulation of gastrointestinal physiology, particularly, in protection of the GI tract from free radical attack and inflammatory reaction. GI tract is the major site exposed to the oxidative stress and inflammation because of the food residue metabolism and the presence of trillions of microbes including the pathological bacteria. Thus, it requires strong protection. Melatonin synthesized by the EC cells provides the onsite protection in GI tract since this molecule is the potent free radical scavenger and effective ant-inflammatory agent. In this review we summarize the available information regarding the structural and functional variability of the EC cells as well as their pathophysiological roles in the GI tract. The focus is given to the protective effects of melatonin produced by the EC cells on the oxidative stress, inflammation and microbiota balance in GI tract.
Melatonin modifies tumor hypoxia and metabolism by inhibiting HIF-1α and energy metabolic pathway in the in vitro and in vivo models of breast cancer
Authors: Mota André De Lima , Jardim-Perassi Bruna Vitorasso , De Castro Tialfi Bergamin , Colombo Jucimara , Sonehara Nathália Martins , Nishiyama Victor Keniti Gomes , Pierri Vinícius Augusto Gonçalves , Zuccari Debora Aparecida Pires de Campos
Published: December 2019

Breast cancer is the most common cancer among women and has a high mortality rate. Adverse conditions in the tumor microenvironment, such as hypoxia and acidosis, may exert selective pressure on the tumor, selecting subpopulations of tumor cells with advantages for survival in this environment. In this context, therapeutic agents that can modify these conditions, and consequently the intratumoral heterogeneity need to be explored. Melatonin, in addition to its physiological effects, exhibits important anti-tumor actions which may associate with modification of hypoxia and Warburg effect. In this study, we have evaluated the action of melatonin on tumor growth and tumor metabolism by different markers of hypoxia and glucose metabolism (HIF-1α, glucose transporters GLUT1 and GLUT3 and carbonic anhydrases CA-IX and CA-XII) in triple negative breast cancer model. In an in vitro study, gene and protein expressions of these markers were evaluated by quantitative real-time PCR and immunocytochemistry, respectively. The effects of melatonin were also tested in a MDA-MB-231 xenograft animal model. Results showed that melatonin treatment reduced the viability of MDA-MB-231 cells and tumor growth in Balb/c nude mice (p <0.05). The treatment significantly decreased HIF-1α gene and protein expression concomitantly with the expression of GLUT1, GLUT3, CA-IX and CA-XII (p <0.05). These results strongly suggest that melatonin down-regulates HIF-1α expression and regulates glucose metabolism in breast tumor cells, therefore, controlling hypoxia and tumor progression.
Specificity and nanomolar potency of melatonin on G-protein coupled melatonin MT1 and MT2 receptors expressed in HEK-293T human embryo kidney cells
Authors: Rivas-Santisteban Rafael , Reyes-Resina Irene , Raich Iu , Pintor Jesus J , Alkozi Hanan Awad , Navarro Gemma , Franco Rafael
Published: December 2019

This is a pre-registered study, i.e. a study whose hypotheses and experiments designed to address these hypotheses have been deposited in a database before starting the experiments. The study aims at assessing the Gs versus Gi coupling and the potency of melatonin in the human version of melatonin MT1 and MT2 G-protein-coupled receptors expressed in HEK-293T cells. The results show that these receptors are Gi but not Gs coupled. By using a standard procedure of modulation of 0.5 µM forskolin-induced cAMP levels, it was found that the potency on MT2 receptor-mediated actions is in the low nanomolar range, but the potency on MT1 receptor is in the high nanomolar range.  The potency of melatonin to stimulate the MT2 receptor is similar to that of a selective agonist, N-[2-(2-methoxy-6H-isoindolo[2,1-a]indol-11-yl)ethyl]butanamide (IIK7). Overall, the data on the potency of melatonin on its receptors will provide a new look for melatonin research. It is important to consider this finding for appropriately addressing physiological or therapeutic effects based on melatonin potency. Thus, the low doses of melatonin used in the existing prolonged release preparations or in other supplements should be revisited.
THE OCCURRENCE OF OBESITY AMONG STUDENT AT ELEMENTARY SCHOOL LAMPUNG-INDONESIA
Authors: Novikasari Linawati , Kunang Analia , Girsang Vierto Irennius
Published: December 2019

Background: Fast food is one that causes the risk of obesity and cause health problems. Nowadays, the occurrence of obesity in children tends to increase, and many other factors that can make obesity in children.Purpose: Knowing that factors associated with occurrence of obesity among student in Elementary School (Sekolah Dasar Negeri 2)  Labuhan Bandar Lampung 2018Methods: This research was quantitative with cross sectional approach. Population in this research is all student at Elementary School (Sekolah Dasar Negeri 2)  Labuhan Dalam Bandar Lampung with the sample of 63 respondents (simple random sampling).Results: Finding, genetic factor were 33 (52,4%)  respondents with p-value 0,001, food intake factor 35 (55,6%) respondent with p-value 0,010 and physical activity factor 32 (50,8%) respondent with p-value 0,007.Conclusion: There is a relationship between genetic factors, food intake factor and physical activity factor with the occurrence of obesity among student in Elementary School (Sekolah Dasar Negeri 2)  Labuhan Bandar Lampung 2018. Suggestion, this research could be used as base data, also need to do another research with number of respondent and different method. School management to report to public health services (Puskesmas) to provide nutritionist to give health education to student about obesity.
REDUCTION OF ANXIETY IN CHILDREN FACING HOSPITALIZATION BY PLAY THERAPY: ORIGAMI AND PUZZLE IN LAMPUNG-INDONESIA
Authors: Pribadi Teguh , Elsanti Devita , Yulianto Andri
Published: December 2019

Background: At the time of hospitalization of children, they feel uncomfortable such as an anxiety. Statistics data base in 2010 in Indonesia reported that in 35 of 420 children has stress during hospitalization. However during hospitalization the children must be cooperate in treatment for recovery.Purpose: Knowing the influence of play therapy: origami and puzzles for reducingan anxiety to children at Pertamina Bintang Amin Hospital, Bandar Lampung-Indonesia 2018.Methods: Quantitative researchwith design used quasi-experimental. The study population was all patient at pediatric ward at Pertamina Bintang Amin Hospital, Bandar Lampung Indonesiawith 50 children as sampleand used instruments: Zung Self-Rating Scale (ZSRAS) and Tailor Manifest Anxiety Scale (T-MAS).The statistical analysis used an independent T test.Results: Finding significane different of the total score of anxiety before and after play therapy (before play therapy: origami and puzzle were 20.2and20.7) and (after play therapy: origami and puzzle were 14.9 and 12.7). The total score rates was descrease of 5.27 in origami therapy and of 8.0 in puzzle therapy with p-value of 0.000.Conclusion: There was differences effect in both of play therapy: origami and puzzle to reducing an anxiety.It is suggestions to management hospital to provide play therapy such as origami and puzzle as an alternative therapy to reduce anxiety to the children due to hospitalization and thus supporting the healing process.
BODY MASS INDEX (BMI) AMONG PATIENTS WITH HYPERTENSION
Authors: Platini Hesti , Hastuti Widia , Andoko Andoko
Published: December 2019

Background: Hypertension or high blood pressure is still a high cause of death in the world. One factor in the occurrence of hypertension is poor nutritional status. Measurement of nutritional status is by knowing body mass index.Purpose: To describe the body mass index (BMI) values in patients with hypertension.Methods: Descriptive with cross sectional approach with consecutive sampling. The number of samples was 40 respondents. Data retrieval is measurement of blood pressure, height and weight. Data analyzed and made by frequencies and percentages.Results: The highest number of hypertension was in the age range of  60-74 years old and the highest gender in this research is women and hypertension in grade I with overweight body mass index values (35%), normal body mass index (62.5%).Conclusion: This study shows that hypertensive patients at Public Health Centre (Puskesmas Pasundan Garut) was show a high body mass index (BMI) value. By early detection to prevent of further severe complications and management of hypertension can be done to improve the quality of life.
CONTRIBUTING FACTORS RELATED TO TYPE 2 DIABETES MELLITUS AMONG ELDERLY: RETROSPECTIVE COHORT STUDY IN LAMPUNG-INDONESIA
Authors: Setiawati Setiawati , Rahmayati Septina , Marliyana Marliyana
Published: December 2019

Background: Type II Diabetes Mellitus is the most common non-communicable diseases among the elderly. Several modifiable and non-modifiable factors contributed to the occurrence of these diseases.Purpose: Describing of the factors related to the occurrence of type 2 Diabetes Mellitus among the elderly at an integrated development post non- communicable diseases (Posbindu PTM Way Halim) Bandar Lampung-Indonesia.Methods: The type of this research is quantitative, from database in the medical record with total of 74 by purposive random sampling. Data analyzed by univariate and bivariate (chi-squared).Results: Smoker (p-value =  0.016; OR 3.429), physical activity (p-value = 0,000 ; OR 7.467) and waist circumference (p-value = 0.011 OR 4,091). Those were main factors that influence  to the occurrence of DM among eldely. Conclusion: It is suggested to management Public Health Services (Puskesmas) to establish a more integrated development post non- infectious diseases (Posbindu) to reach all the elderly. By controlling all of the factors that influence the occurrence of type II DM in various ways, so that the elderly will have a better life and prevent the complications
FAMILY ROLES AND BLOOD GLUCOSE MANAGEMENT IN PATIENTS WITH TYPE 2 DIABETES MELLITUS AT BANDAR LAMPUNG, INDONESIA
Authors: Chrisanto Eka Yudha , Saputra Yoko , Nadrati Bahjatun
Published: December 2019

Background: Diabetes Mellitus ranks 8th out of 10 major diseases in Lampung province with a prevalence of 0.4%. Based on Rikesdas Lampung Province results in 2013 it is known that DM pavelence reaches 0.7% with pravelensi in Bandar Lampung reaches 0.8% and for Public Health Services (Puskesmas) Panjang in 2017 cases of DM was found as much as 2145.Purpose: Knowing that the relation family roles and blood glucose management  in patients with type 2 Diabetes Mellitus at Bandar Lampung, IndonesiaMethods: This was quantitative research type with analytical survey design and cross sectional approach. Population in this research were all patient of Diabetes Mellitus (DM) Type 2 in April 2018, at Puskesmas Panjang Bandar Lampung and the samples were 79 respondents given of questioner. The statistical test used is Chi Square test.Results: The frequency distribution of respondents aged between 60-69 years 54 (68.4%) respondents, female of 54 (68.4%) respondents, primary elementary education (45.6%) respondents, Duration of DM ≥ 5 years of 42 (53.2%) respondents, uncontrol blood sugar as many as 53 respondents (67.1%), poor family roles as many as 42 (53.2%) respondents, with p-value 0,000.Conclusion: There the relation of family roles and blood glucose management  in patients with type 2 Diabetes Mellitus at Bandar Lampung, IndonesiaSuggestions: The management of Public Health Centre (Puskesmas) to give counseling to the family about the importance of family roles and blood glucose management  in patients with type 2 Diabetes Mellitus
DIFFERENCES IN LEUKOCYTE RATE BETWEEN ACUTE NONPERFORATED AND PERFORATED APPENDICITIS IN HOSPITALISED PATIENTS BANDAR LAMPUNG-INDONESIA
Authors: Ladyani Festy , Dewi Nur Fitria
Published: December 2019

Background: Acute appendicitis is one of the most common acute abdominal pain. A late check up and diagnosis could bring harms which is turning into perforated appendicitis. Leukocyte count is a laboratory collation that is generous and quick to diagnose the acute apendicitis and perforated appendicitis, however there’s no certain limit of the leukocytes count to recognize whether it is acute apendicitis or perforated appendicitis.Purpose: This research was to find out the comparison of leucocyte count average between acute appendicitis and perforation appendicitis in Dr. H. Abdul Moeleok public hospital of Lampung province in 2014-2016.Methods: An analytic research with cross sectional approach. Population was 382 patients with appendicitis in Dr. Hi. Abdul Moeloek public hospital. Samples were taken using total sampling technique with 196 respondent samples for acute appendicitis and 196 respondent samples for perforation appendicitis. Data were analyzed by using univariate analysis with percentage and bivariate analysis with t-test.Results: the average of leucocyte count of acute appendicitis patients was 10,907 with minimum and maximum leucocyte count of 5,000 and 18,500 respectively. The average of leucocyte count of perforation appendicitis patients was 22,789 with minimum and maximum leucocyte count of 16,500 and 31,000 respectively. There were differences of leucocyte counts between acute appendicitis patients and perforation appendicitis patients with p-value < 0.05.Conclusion: there were significant differences of leucocyte count averages between acute appendicitis and perforation appendicitis.
BULLYING BEHAVIOR AMONG TEENAGERS AT JUNIOR HIGH SCHOOL LAMPUNG -INDONESIA
Authors: Pribadi Teguh , Utami Susri , Marliyana Marliyana
Published: December 2019

Background: Cases of bullying in schools are common at this time. In Junior High School (Sekolah Menengah Pertama 2 Muhammadiyah) Bandar Lampung in 2017 has 16 cases of bullying behavior or about 15% of cases.Purpose: Knowing Factors Associated With Bullying Behavior of Junior High School (Sekolah Menengah Pertama 2 Muhammadiyah) Bandar Lampung Year 2018.Methods: Quantitative research using cross sectional. The participant was 109 students as respondents (total sampling) and obtained 92 respondents as suitable of inclusion criteria. Univariate data analysis to know the frequency distribution and bivariate analysis using chi-square test.Results: In this study showed the frequency distribution of respondents had low self esteem 38 (84.6%) behaved bullying, poor family care pattern 44 (88%) bullying behavior, 39 poor peers 39 (79,6%) bullying behavior. the relationship between bullying behavior and self-esteem (p value 0,000), bullying behavior and family parenting (p value 0,000), bullying behavior and  peers group (p value 0,000).Conclusion: There is a relationship between factors (self esteem, family parenting, and peers) with bullying behavior among students of Junior High School (Sekolah Menengah Pertama 2 Muhammadiyah) Bandar Lampung 2018. Suggest to the highest Education Department of Bandar Lampung,  especially through Counseling department to be conducted another research in another school and follow up on the results of this study as: doing  school programs that creating networks support, sports, consultants, art, community and anti-bullying campaigns.
HEALTH PROBLEMS AMONG THE ELDERLY AT MAJALAYA PUBLIC HEALTH CENTERS (PUSKESMAS) WEST JAVA-INDONESIA
Authors: Shobarina Agiesta Sephya , Sriati Aat , Shalahuddin Iwan
Published: December 2019

ABSTRACT Background: Elderly Health problems can lead to decline in elderly body functions and become a factor that improves health problems. As a result, many elderly people come to public health services every day with the same complaints and different complaints.Purpose: to recognize the description of health problems among the elderly at Majalaya  public health centers (Puskesmas) West Java-IndonesiaMethods: A descriptive research with documentation study. The object of research is medical records of elderly who went to public health center during the last 1 year from April 2017 until March 2018. The number of samples is 3899 elderly based on elderly visit number gained by total sampling technique. The technique of data collection is through elderly medical records at Majalaya Public Health Centre during  the last 1 year. This research uses frequency distribution and proportion analysis.Results: Showed that almost all elderly came independently without being escorted by their families and hypertension was the highest-ranking health problems experienced by elderly (40,9%) others were rheumatoid atritis (14,9%), cough  and flu (8.2%) , gastritis (7,9%) and chepalgia (7.6%) , they were the 5th highest health problems experienced by the elderly at Majalaya Public Health center during the last 1 year.Conclusion: Among 22 health problems that are experienced by elderly, hypertension is the most common problem complained by elderly. It is recommended that health care workers optimize services regarding the handling and treatment of chronic health problems among elderly.
IRON DEFICIENCY ANEMIA AND CURRENT STATE OF KNOWLEDGE AMONG ADOLESCENT GIRLS, LAMPUNG-INDONESIA
Authors: Nurhayati Nurhayati , Perdani Agni Laili , Trismiyana Eka
Published: December 2019

Background: Anemia is a condition with lower hemoglobin and hematocrit levels. The number of iron deficiency in Indonesia among children aged 5 to 14 years is still quite high at 26.4%. Less knowledge in adolescent caused by the consumption of unhealthy food or light snacks.Purpose: To describe the relationship of  Iron deficiency anemia and  current state of knowledge among adolescent girls in 1st Mesuji Junior High School.Methods: The type of this research is an observational study with a cross-sectional method. The population of this study was members of all adolescent girls in class VIII and IX at 1st Mesuji Junior High School with the total is 87 respondents. Data collected by a questionnaire and analyzed used chi-square.Results: The most of the respondents 47 (54%) had poor knowledge about Iron deficiency anemia and experienced of Iron deficiency anemia 44 (50.6%) with p-value = 0.001.  Conclusion: There is a relationship between Iron deficiency anemia and  current state of knowledge among adolescent girls, Mesuji Junior High School in 2018.  It is recommended for school management to further improve health promotion or counseling about Iron deficiency anemia in adolescent girls, especially in prevention.
The correlation of the low birth weight with stunting incident on child aged 6-59 months in Lampung-Indonesia
Authors: Nurmalasari Yesi , Alfarisi Ringgo , Kartika Syawalia
Published: December 2019

Background: Stunting or short was failed condition to grow of the baby (0-11 months old) and toodler (12-59 months old) impacted of the cronic malnutrition especially in the first 1.000 days of life its effecting the children to be too short. LBW is a factor that most dominant risk against stunting on child.Purpose : This research was to know the Correlation between history of low body weight of birth with the genesis stunting of the toodler aged 6-59 months in Mataram Ilir Village Seputih Surabaya Central Lampung 2019.Methods: This type of research is analysis observation with cross sectional design with purposive sampling as the sampling technique and Chi Square test as the bivariate analysis.Results: The results of the analysis showed that the frequency distribution of children with a history of LBW was 85 (35%), and the proportion of respondents with a history of normal weight birth was 152 (64.1%). While the frequency of the incidence of infants with normal height was 141 (59.5%), and the frequency of genesis stunting was 96 (40.5%). The results showed that the p-value was 0.005 and OR  was 2.282 (95% CI: 1.29 - 3.8).Conclusion: There was a significant relationship between history of LBW and genesis stunting.
Nursing education on collaborative discharge planning and motivating patients to control for further care and management
Authors: Kusumaningsih Dewi , Agustianda Muhammad
Published: December 2019

Background: Nurse as a health worker had a role as educators. The role of nurse educators could be seen from 10 inpatients resulted there were 4 inpatients (40%) stated that nurses did their roles accurately and 6 patients (60%) stated that there were nurses didn’t their roles properly. This condition could cause an increasing amount of patients who uncontrolled  at Dr. A. Dadi Tjokrodipo Hospital  Bandar Lampung.Purpose: To know there was a correlation of nursing education on collaborative discharge planning and motivating patients to control for further care and managementMethods: This research was quantitative method. The design of this study was an analytical survey with a cross-sectional. The samples used in this study were 136 people. Collecting data sampling used a consecutive sampling. The statistical test used a chi-square test.Results: The roles of nurse educator which had not good categories were 73 respondents (53.7%) and the roles of nurse educator which had good category were 63 respondents (46.3%). Low control motivations were 69 respondents (50.7%) and high control motivations were 67 respondents (49.3%). The results of data analysis using the chi-square test showed p-value = 0.001.Conclusion: There was a correlation of the roles of the nurse educator in discharge planning with motivation of inpatients for control. It was expected that the results of this study could be used as material for consideration and input for the hospital to be able to know the importance of the role of nurse educators in discharge planning.
"Teamwork cooperation": Nurse’s experience of cardiac arrest nursing care
Authors: Budi Arif Wahyu Setyo , Afiyanti Yati , Azidin Yustan
Published: December 2019

Background : Emergency conditions are conditions that occur suddenly and are very life-threatening, so help must be given quickly, precisely and correctly. One of the life-threatening conditions is cardiac arrest, which is a condition where the heart cannot function anymore, and requires collaboration between health personnel in providing help and this always ends in death. The incidence of cardiac arrest at the Ulin Regional General Hospital during May to June 2017 was 88 cases and most of the deaths occurred in patients. Cardiac arrest can still be saved by the correct nursing care process so that return of spontaneous circulation can occur.Purpose : Identify and explore the experience of nurses doing nursing care for cardiac arrest.Methods: This type of research is qualitative with a phenomenological approach. The number of participants in this study were 9 nurses in the emergency room and intensive care unit. The process of retrieving data using interview guides, and data analysis using Colaizzy.Results: This study obtained a major theme, "Collaborative Teamwork" when providing nursing care for cardiac arrest. This theme was formed from two sub-themes namely "division of job teams", "collaboration" and KIE to the patient's family.The participant describing the existence of maintained teamwork can help smooth the process of nursing cardiac arrest so that patients can return to the condition of return of spontaneous circulation.
Acute respiratory distress syndrome after traumatic brain injury in Purwokerto-Indonesia
Authors: Munjiati Munjiati , Walin Walin , Herry Herry , Ferry Ferry
Published: December 2019

Background: Traumatic brain injury  was most source morbidity and mortality at patient by real trauma. Traumatic brain injury  case who dead before to the hospital was caused by shock, hypoxemia and hypercapnia. So needed basic of knowledge and ability to take care of patient of breath disease.Purpose: To explore the factors that influence respiratory distress on traumatic brain injury  at Prof. Dr. Margono Soekarjo hospital in Purwokerto, IndonesiaMethods: The kind of this research was correlation with using cross sectional approach. The population of this research was all patients with traumatic brain injury  in the emergency ward Prof. Dr. Margono Soekarjo hospital Purwokerto on November-Desember 2017. The sample take as 19 person. The analyzed used was Coefficient Contingency Test.Results: The result of this research shows that patient with traumatic brain injury had respiratory distress (57.9%) higher following by phlegm’s accumulation (52,6%) also had the decrease of consciousness (47,4%). There was real influence as statistic between phlegm’s accumulation and respiratory distress on traumatic brain injury (p=0.040). There was as statistically significant between the decrease of consciousness and respiratory distress on traumatic brain injury (p=0,009).Conclusion: It can be concluded that there was a statistically significant influence between decreased awareness of respiratory distress on traumatic brain injury (p=0.0009)
The effect of cinnamon on pain among teenage girls with primary dysmenorrhea in Lampung Indonesia
Authors: Evayanti Yulistiana , Hidayat Sri Andayani
Published: December 2019

Background: Dysmenorrhea is an event that occurs during menstruation that occurs and causes teenage girls  are absent from school and daily activities. Based on the results of the survey on November at  Bandar Lampung high school, of the 10 teenage girls who had menstruation as many as 7 (70%)  often complian of severe pain  during menstruation.Purpose: Knowning the effect of cinnamon on pain among teenage girls with primary dysmenorrhea in Lampung IndonesiaMethods: The quantitative research, the design of this study is Pre-experimental with the on-group pretest-posttest approach. The population was teenage girls in grade X and XI at Bandar Lampung  high school and samples were 30 teenagers. Sampling of this research was using purposive sampling technique which was carried out from April, 2019  to Juli, 2019. The analysis used univariate analysis and bivariate analysis using the T test.Results: The mean of dysmenorrhea before consumption was 6.67 and after consumption was 2.13 . The effect of cinnamon on pain among teenage girls with primary dysmenorrhea with p-value 0.00 <0.05.Conclusion: The significant effect of cinnamon on pain among teenage girls with primary dysmenorrheain at Bandar Lampung 13th high school in 2019. Finding in this study could be applied as alternative therapy for teenager and further research need more deep exlporation.
Caring behaviors by nurses in patients’ perceptions and experiencing an anxiety during hospitalization
Authors: Pribadi Teguh , Herwan Herwan
Published: December 2019

Background: Feeling anxious due to lack of attention from the surroundings can be solved by providing a good caring performance from the health workers. The nursing experts place caring as the core principle of a nurse in performing his work. Caring behavior refers to giving attention to patients, respecting others, and showing empathy so that a nurse should maintain the relationship with the patients by having this the patients can commit and be responsible with them.Purpose: Knowing nursing caring behavior on anxiety level of hospitalized patients.Methods: This study was a quantitative study. The design was analytical with cross sectional approach. The population of the study consisted of 262 adult patients in average registered at Ryacudu General Hospital, Kotabumi Lampung. The elder and pediatric inpatients were excluded. The samples were 79 respondents. The sampling technique was accidental sampling.Results: Based on the statistical analysis, the p value was 0.487 or the p value > 0.05, there wasn’t nursing caring behavior on anxiety level of hospitalized patients.Conclusion: The health practitioners should improve their nursing quality by following nurse training about therapeutic communication. It is expected that health workers can increase caring so that patient anxiety can be reduced and can improve the quality of health services by providing training to all nursing staff on good and correct therapeutic communication.
Molecular Identification of Vibrio alginolyticus Causing Vibriosis in Shrimp and Its Herbal Remedy
Authors: ABDUL HANNAN MD. , MAHBUBUR RAHMAN MD. , NURUNNABI MONDAL MD. , SUZAN CHANDRA DEB , CHOWDHURY GAZLIMA , TOFAZZAL ISLAM MD.
Published: December 2019

Penaeus monodon is highly susceptible to vibriosis disease. Aims of the study were to identify the pathogen causing vibriosis in P. monodon through molecular techniques and develop a biocontrol method of the disease by application of herbal extracts. Shrimp samples were collected aseptically from the infected farm and the bacteria were isolated from the infected region of those samples. Based on phenotypic identification, several isolates were identified as Vibrio sp. 16S rRNA gene sequences of the selected isolates exhibited 100% homology with V. alginolyticus strain ATCC 17749. An in vivo infection challenge test was performed by immersion method with V. alginolyticus where these isolates caused high mortality in juvenile shrimp with prominent symptoms of hepatopancreatic necrosis. Antibiogram profile of the isolates was determined against eleven commercial antibiotic discs whereas the isolates were found resistant to multiple antibiotics. A total of twenty-one herbal extracts were screened where Emblica officinalis, Allium sativum, and Syzygium aromaticum strongly inhibited the growth of V. alginolyticus in in vitro conditions. In in vivo conditions, the ethyl acetate extracts of E. officinalis and A. sativum successfully controlled the vibriosis disease in shrimp at a dose of 10 mg/g feed. This is the first report on molecular identification and biocontrol of V. alginolyticus in shrimp in Bangladesh.
Molecular Epidemiology of Hepatitis B Virus in Turkish Cypriot
Authors: SUMER UNAL , SAYAN MURAT
Published: December 2019

There is an increased demand for molecular and epidemiological information regarding Hepatitis B Virus (HBV) infection as the disease severity depends on these specifications. We have aimed to analyze nucleos(t)ide analogues (NA) resistance and typical HBsAg escape mutations with the dispersion of HBV genotype/subgenotype/HBsAg serotypes on overlapping pol/S gene regions in the Turkish population. Samples were collected in Northern Cyprus. Reverse transcriptase (rt) region between 80–250 amino acids were amplified. Typical HBsAg escape mutations were determined as HBIg escape (6.48%), vaccine escape (8.34%), HBsAg misdiagnosis (9.25%), and immune escape mutations (8.34%). NAs resistances were determined as primary (2.78%), partial (2.78%), and compensatory mutations (26.85%) in overlapping pol/S gene region. The study patients were predominantly infected with HBV genotype D/D1 (98%). However, the predominant HBsAg serotype was ayw2 (99%). The most common NA resistance mutation was rtQ215H/P/S (16.67%), however, for S gene the misdiagnosis mutations were observed most frequently (9.25%). We can conclude that HBV D/D1 is the dominant strain and ayw2 is the dominant serotype in the Turkish Cypriot. Cyprus is an island located in the Eastern Mediterranean region, and it is, therefore, a key location for human trafficking and immigration; as a result of this reputation, it is necessary to analyze HBV phylogenetically for local dynamics, and our results indicate that treatment naïve population is prone to these pol/S gene mutations. However, if HBV strains were also analyzed among Greek Cypriots too, this would enable a complete island survey. With this work, we believe that we have enlightened this subject for further research.
The Diversity of the Endobiotic Bacterial Communities in the Four Jellyfish Species
Authors: LIU QING , CHEN XINTONG , LI XIAOYA , HONG JIANPING , JIANG GUIXIAN , LIANG HONGYU , LIU WENWEN , XU ZHENG , ZHANG JING , WANG WEI , XIAO LIANG
Published: December 2019

The associated microbiota plays an essential role in the life process of jellyfish. The endobiotic bacterial communities from four common jellyfish Phyllorhiza punctata, Cyanea capillata, Chrysaora melanaster, and Aurelia coerulea were comparatively analyzed by 16S rDNA sequencing in this study. Several 1049 OTUs were harvested from a total of 130 183 reads. Tenericutes (68.4%) and Firmicutes (82.1%) are the most abundant phyla in P. punctata and C. melanaster, whereas C. capillata and A. coerulea share the same top phylum Proteobacteria (76.9% vs. 78.3%). The classified OTUs and bacterial abundance greatly decrease from the phylum to genus level. The top 20 matched genera only account for 9.03% of the total community in P. punctata, 48.9% in C. capillata, 83.05% in C. melanaster, and 58.1% in A. coerulea, respectively. The heatmap of the top 50 genera shows that the relative abundances in A. coerulea and C. capillata are far richer than that in P. punctata and C. melanaster. Moreover, a total of 41 predictive functional categories at KEGG level 2 were identified. Our study indicates the independent diversity of the bacterial communities in the four common Scyphomedusae, which might involve in the metabolism and environmental information processing of the hosts.
Inhibition of Drug Resistance of Staphylococcus aureus by Efflux Pump Inhibitor and Autolysis Inducer to Strengthen the Antibacterial Activity of β-lactam Drugs
Authors: LUAN WENJING , LIU XIAOLEI , WANG XUEFEI , AN YANAN , WANG YANG , WANG CHAO , SHEN KESHU , XU HONGYUE , LI SHULIN , LIU MINGYUAN , YU LU
Published: December 2019

This study explored a potential treatment against methicillin-resistant Staphylococcus aureus (MRSA) infections that combines thioridazine (TZ), an efflux pump inhibitor, and miconazole (MCZ), an autolysis inducer, with the anti-microbial drug cloxacillin (CXN). In vitro, the combination treatment of TZ and MCZ significantly reduced 4096-fold (Σ (FIC) = 0.1 – 1.25) the MIC value of CXN against S. aureus. In vivo, the combination therapy significantly relieved breast redness and swelling in mice infected with either clinical or standard strains of S. aureus. Meanwhile, the number of bacteria isolated from the MRSA135-infected mice decreased significantly (p = 0.0427 < 0.05) after the combination therapy when compared to monotherapy. Moreover, the number of bacteria isolated from the mice infected with a reference S. aureus strain also decreased significantly (p = 0.0191 < 0.05) after the combination therapy when compared to monotherapy. The pathological changes were more significant in the CXN-treated group when compared to mice treated with a combination of three drugs. In addition, we found that combination therapy reduced the release of the bacteria-stimulated cytokines such as IL-6, IFN-γ, and TNF-α. Cytokine assays in serum revealed that CXN alone induced IL-6, IFN-γ, and TNF-α in the mouse groups infected with ATCC 29213 or MRSA135, and the combination of these three drugs significantly reduced IL-6, IFN-γ, and TNF-α concentrations. Also, the levels of TNF-α and IFN-γ in mice treated with a combination of three drugs were significantly lower than in the CXN-treated group. Given the synergistic antibacterial activity of CXN, we concluded that the combination of CXN with TZ, and MCZ could be developed as a novel therapeutic strategy against S. aureus.
Antibiotic Resistance Among Uropathogenic Escherichia coli
Authors: KOT BARBARA
Published: December 2019

Urinary tract infections (UTIs) belong to the most common community-acquired and nosocomial infections. A main etiological factor of UTIs is uropathogenic Escherichia coli (UPEC). This review describes the current state of knowledge on the resistance of UPEC to antibiotics recommended for the treatment of UTIs based on the available literature data. Nitrofurantoin and fosfomycin are recommended as first-line therapy in the treatment of uncomplicated cystitis, and the resistance to these antimicrobial agents remains low between UPEC. Recently, in many countries, the increasing resistance is observed to trimethoprim-sulfamethoxazole, which is widely used as the first-line antimicrobial in the treatment of uncomplicated UTIs. In European countries, the resistance of UPEC to this antimicrobial agent ranges from 14.6% to 60%. The widespread use of fluoroquinolones (FQs), especially ciprofloxacin, in the outpatients is the cause of a continuous increase in resistance to these drugs. The resistance of UPEC to FQs is significantly higher in developing countries (55.5–85.5%) than in developed countries (5.1–32.0%). Amoxicillin-clavulanic acid is recommended as first line-therapy for pyelonephritis or complicated UTI. Resistance rates of UPEC to amoxicillin-clavulanic acid are regionally variable. In European countries the level of resistance to this antimicrobial ranges from 5.3% (Germany) to 37.6% (France). Increasing rates of UPEC resistance to antimicrobials indicate that careful monitoring of their use for UTI treatment is necessary.
Diversity, Virulence Factors, and Antifungal Susceptibility Patterns of Pathogenic and Opportunistic Yeast Species in Rock Pigeon (Columba livia) Fecal Droppings in Western Saudi Arabia
Authors: ABULREESH HUSSEIN H. , ORGANJI SAMEER R. , ELBANNA KHALED , OSMAN GAMAL E.H. , ALMALKI MESHAL H.K. , ABDEL-MALEK AHMED Y. , GHYATHUDDIN ABDULLAH A.K. , AHMAD IQBAL
Published: December 2019

Bird fecal matter is considered a potential source of pathogenic microbes such as yeast species that contaminate the environment. Therefore, it needs to be scrutinized to assess potential environmental health risks. The aim of this study was to investigate the diversity of the yeasts in pigeon fecal droppings, their antifungal susceptibility patterns, and virulence factors. We used culturing techniques to detect the yeasts in pigeon fecal droppings. The isolates were then characterized based on colony morphologies, microscopic examinations, and biochemical reactions. The molecular identification of all yeast isolates was performed by sequencing of the amplified ITS gene. Genes encoding virulence factors CAP1, CAP59, and PLB were also detected. Antifungal susceptibility patterns were examined by the disk diffusion method. A total of 46 yeast-like isolates were recovered, and they belonged to nine different genera, namely, Cryptococcus, Saccharomyces, Rhodotorula, Candida, Meyerozyma, Cyberlindnera, Rhodosporidium, Millerozyma, and Lodderomyces. The prevalence of two genera Cryptococcus and Rhodotorula was high. None of the yeast isolates exhibited any resistance to the antifungal drugs tested; however, all pathogenic Cryptococcus species were positive for virulence determinants like urease activity, growth at 37°C, melanin production, the PLB and CAP genes. This is the first report on the molecular diversity of yeast species, particularly, Cryptococcus species and their virulence attributes in pigeon fecal droppings in Saudi Arabia.
The Composition of Fungal Communities in the Rumen of Gayals (Bos frontalis), Yaks (Bos grunniens), and Yunnan and Tibetan Yellow Cattle (Bos taurs)
Authors: WANG HOUFU , LI PENGFEI , LIU XUCHUAN , ZHANG CHUNYONG , LU QIONGFEN , XI DONGMEI , YANG RENHUI , WANG SHULING , BAI WENSHUN , YANG ZHEN , ZHOU RONGKANG , CHENG XIAO , LENG JING
Published: December 2019

The rumen is a microbial-rich ecosystem in which rumen fungi play an important role in the feed digestion of ruminants. The composition of rumen fungi in free-range ruminants such as gayals, yaks, Tibetan yellow cattle, and the domesticated Yunnan yellow cattle was investigated by sequencing an internal transcribed spacer region 1 (ITS1) using Illumina MiSeq. A total of 285 092 optimized sequences and 904 operational taxonomic units (OTUs) were obtained from the four cattle breeds. The rumen fungi abundance and Chao and Simpson indexes were all higher in free-range ruminants than in domesticated ruminants. Three fungal phyla were identified by sequence comparison: Neocallimastigomycota, Basidiomycota, and Ascomycota. Basidiomycota and Ascomycota have very low abundance in the rumen of four breeds cattle but anaerobic fungi (AF) Neocallimastigomycota occurred in a high abundance. In Neocallimastigomycota, the dominant genera were Piromyces, Anaeromyces, Cyllamyces, Neocallimastix, and Orpionmyces in four cattle breeds. The composition of the major genera of Neocallimastigaceae varied greatly among the four cattle breeds. The unclassified genera were unequally distributed in gayals, yaks, Tibetan and Yunnan yellow cattle, accounting for 90.63%, 98.52%, 97.79%, and 27.01% respectively. It appears that free-range ruminants have more unknown rumen fungi than domesticated ruminants and the cattle breeds and animal diets had an impact on the diversity of rumen fungi.