bluuebunny/crossref_metadata_2025 huggingface dataset:
Adams-Oliver syndrome
Authors: Kiselev L. G. , Bessolova N. A. , Kopylova M. S. , Babitskaya D. A. , Seledueva E. D.
Published: January 2023

The article presents the observation of a rare hereditary disease: Adams–Oliver syndrome. In a newborn girl in the postnatal period, a lesion of the distal extremities was revealed in the form of syndactyly of the proximal phalanges of 4–5 and 2–3 fingers, hypoplasia of the nail phalanges of 2–5 fingers of the left foot, fusion of the proximal phalanges and the absence of middle and nail phalanges of 2–3 fingers of the right foot, hypoplasia of the terminal phalanx and the absence of the nail plate of the 2nd finger of the left hand. In addition to malformations of the extremities, anomalies in the development of the skin on the scalp in the form of an area of aplasia and outgrowths, represented by sweat gland hyperplasia with a fibroepithelial outgrowth, were noted. Cardiac pathology was manifested by a heart rhythm disturbance of the type of sinus bradyarrhythmia. Adams–Oliver syndrome is a complex disease with phenotypic variability, which causes difficulties in clinical diagnosis.
Adaptive neural network vibration suppression control of flexible joints space manipulator based on H∞ theory
Authors: You Zhangping , Zhang Wenhui , Shen Jinmiao , Ye Yangfan , Ye Xiaoping , Zhou Shuhua
Published: January 2023

Considering the control problems caused by uncertainties such as inaccurate modeling, external disturbance and joint flexibility, a neural network control method based on H∞ is proposed. By establishing the dynamic model of the free-floating space robot with flexible joints, according to its dynamic characteristics, it is split into a slow subsystem model representing the rigid characteristics and a fast subsystem model representing the flexible characteristics. Based on the H∞ robust control theory, a robust controller based on neural network is designed to realize the decoupling control of the rigid dynamic model, The designed weight adaptive learning rate can ensure the online and real-time adjustment of parameters. Based on Lyapunov theory, it is proved that the designed controller can ensure that the L2 gain of the system is less than the given index. A feedback controller based on velocity differential is designed to compensate the angle error caused by joint flexibility. The experimental simulation results verify that the proposed control method is effective and has good engineering application value.
Private equity investment tenure and financial performance: Evidence from European PIPE transactions
Authors:   HSE University, Berezinets Irina V. , Ilina Yulia B. ,   St. Petersburg State University, Bobyleva Alla Z. ,   Lomonosov Moscow State University, Burov Alexander N. ,   PJSC Bank “Saint-Petersburg”
Published: January 2023

The role of private equity investments in a modern economy is growing. Private equity funds, which operate in the industry, attract capital, and distribute it across a wide range of portfolio companies. These funds hold their stakes in target companies’ capital for different periods of time. Why would a private equity fund choose to invest in portfolio companies for a certain period of time and what would be the impact of such investments on a portfolio company? Is there any relationship between the tenure of investment and the performance of a target company? This paper examines the relationship between the tenure of private equity investments in public equity and financial performance of European companies. Performance is measured by cash flow growth and net debt to EBITDA ratios. Private investments in public equity transactions with public company targets located in Western European countries during a period from 2005 to 2016 were analyzed. The findings reveal the impact of private equity investor presence on the performance of target companies and confirm non-linear effects of the relationships. A nonlinear relationship between private investments in public equity investment tenure and target company’s performance have been found both in terms of its solvency and cash flow growth rate.
Transforming the prohibition of torture in the context of rising terrorist threats
Authors:   Penza State University, Romanovsky Georgy B. , Romanovsky Vladislav G. ,   Penza State University
Published: January 2023

The article explores the content of the prohibition of torture in constitutional and international acts. The ban is absolute, as confirmed by the extensive practice of international human rights organizations. At present, a revision of the general attitude towards torture in Western Europe is taking place against the background of increasing terrorist threats. In the United States, after the September 11, 2001 terrorist attack, at the level of Justice Department directives, certain methods of “intensive interrogation” were allowed in order to obtain information from persons captured during anti-terrorist operations. It was assumed that in the conditions of the “war on terror”, terrorists were not subject to the privileges provided for by the Geneva Conventions in relation to prisoners of war. Our study involves an analysis of a wide range of sources on problems of the use of torture in the context of countering terrorism, and provides an analysis of foreign scientific discussions of the admissibility of torture against terrorists. One argument is the lack of moral boundaries among terrorists themselves, capable of committing deadly attacks against civilians. Supporters of the use of torture proceed from the principle of extreme necessity for obtaining information about the planned terrorist acts. Opponents of torture proceed from the principle of the moral absolute, which does not justify attaining a goal by any means. In modern legal science there is a search for a balance of interests: the dignity of a person suspected of preparing a terrorist act, and the safety of other citizens, society, and the state.
International cooperation in the fight against cyberpression in the context of response to new challenges and threats
Authors:   MGIMO-University, Klevtsov Kirill K.
Published: January 2023

This article explores criminal procedure and other organizational and legal aspects of international cooperation between states in the fight against cybercrime in the face of new challenges and threats. The aim is to identify and consider formal and informal measures of international cooperation in response to transnational cybercrime. Through legal analysis, we demonstrate that such crimes, as a rule, have an international character, as they have negative consequences on the territory of other sovereign countries. The author analyzes various forms of international cooperation in the fight against crime, which include extradition (extradition), legal assistance in criminal matters, transfer of criminal prosecution (judicial proceedings), as well as informal cooperation between law enforcement agencies (international police cooperation), in particular within the framework of US law called “СLOUD Act”. As an empirical basis for the study, materials of Russian operational and investigative practice for 2018–2019, as well as decisions of courts of foreign states, were used. However, the majority of law enforcement agencies deliberately or without intent resort to the practice of obtaining evidence on cybercrimes that are physically located on the territory of another country, independently, without obtaining the consent of this state. This happens through a remote connection in real time to the subscriber device of a criminally prosecuted person or its withdrawal from a victim or witness located on the territory of the state by law enforcement agencies that conduct proceedings on a cybercrime case with subsequent inspection to find information relevant to the case, as well as through the use of other legal methods.
Legalization of marijuana use in comparative criminal legislation
Authors:   College of Criminalistics and Security in Nish, Slavković Vukan ,   University of Montenegro
Published: January 2023

In light of the rapidly shifting legislation regarding the legalization of marijuana use, the popular notion seems to be that marijuana is a harmless pleasure, access to which should not be regulated or considered illegal. World Health Organization recommended to delete cannabis and cannabis resin from Schedule IV of the UN Single Convention on Narcotic Drugs (1961), but to maintain it in Schedule I of the 1961 Convention. The UN Commission on Narcotic Drugs decided by 27 votes to 25 and with one abstention to follow this recommendation. Тhere is the issue of how much this decision will affect the legalization of marijuana in the world. In the paper are analyzed two legislation of the Anglo-Saxon legal system, which supported this initiative (Canada and USA) and legislation of Euro-Continental legal area (Russia) that did not accept the reclassifying of cannabis from the 1961 Convention. Author has compared the Canadian code with Uruguayan, and the U. S. bill with the Mexican legislation, because Mexican bill does not provide the full legalization of marijuana use. In the Russian Federation, all deeds related to narcotic drugs, which were committed on a significant, large, and an especially large scale, and also all acts coherent to traffic of narcotic drugs, regardless of its scale, are regulated by Criminal Code of the Russian Federation. Otherwise, there will be applied an administrative law.
Legal regulation of liability for offenses related to inducement to suicide: Domestic and foreign experience
Authors:   Kazan (Volga Region) Federal University, Talan Maria V. , Shalagin Anton E. ,   Kazan Law Institute of the Ministry of Internal Affairs of Russia, Idiyatullov Almaz D. ,   Kazan Law Institute of the Ministry of Internal Affairs of Russia
Published: January 2023

In this work, a team of authors tried to analyze the current state of legal regulation of acts related to suicide under Russian and foreign criminal legislation. For this, historical, comparative legal, comparative and systemic-structural methods were used. The study reflects the evolution of beliefs about suicide. It is noted that the legislation of more than 160 countries contains provisions on liability for criminal involvement in the suicide of another person. More than 38 legal systems do not mention suicide as a criminal institution. Particular attention is paid to five groups of crimes associated with suicide. The first group includes responsibility for attempted suicide, which is punishable in more than 24 countries around the world. The following contains a wide list of acts related to the inducement of suicidal behavior in the form of: driving to suicide or attempted suicide, inducement to commit suicide (incitement) or assistance in committing it (assistance, aiding, advice, consultation). The third group is made up of norms that consider these acts as one of the types of murder or incitement to it. The fourth group contains corpus delicti with responsibility for disseminating information about methods of committing suicide, promoting suicide and public calls for its implementation. The last group contains privileged compounds with responsibility for euthanasia. The article reveals the features of new types of criminal activity carried out by spreading suicidal ideology on the Internet, persuading children and adolescents to commit suicide by negative information impact and drawing them into computer games that pose a threat to life and health. The article reflects the relationship of suicide with cyberbullying, cyber-harassment, as well as with the illegal activities of destructive criminal organizations (sects), extremism and terrorism. The necessity of further improvement of criminal law mechanisms for protecting individuals from criminal encroachments and anti-suicidal measures is substantiated.
Ideas about real and digital worlds as part of the current worldview of adolescents and parents in a digital society: Possibilities for adaptation
Authors:   Russian Presidential Academy of National Economy and Public Administration, Soldatova Galina , Chigarkova Svetlana ,   Lomonosov Moscow State University, Ilyukhina Svetlana ,   Academy of Social Management
Published: January 2023

The introduction of digital devices into all spheres of life has led to a significant restructuring of our everyday life and the world of the modern person. The real world is increasingly and actively extended by the digital environment, forming a historically unique life in a mixed online and offline reality. Psychology still lacks analyses of the worldview of adolescents most actively socialized in real and virtual spaces and comparisons with perceptions of elder generations that would contribute to understanding the choice of behavioral strategies of different generations and their adaptation to digital transformations. This study compares representations of real and virtual spaces as components of the world picture in adolescents and parents with different levels of user activity, digital competence, and value orientations. The sample was comprised of 282 adolescents aged 14–17 and 337 parents of adolescents of the same age. Adolescents’ pictures of the real and virtual worlds converge, while parents keep these worlds apart in their general system of perceptions. Adolescents and parents have different visions of the virtual world, while they are in common perceptions of the real world. The more time both adolescents and parents spend online, the more positive they perceive the virtual world, which is also characteristic of parents with a high level of digital competence. Adolescents with various value orientations differ in their perceptions of the real world only, while parents differ in their perceptions of both the real world and the virtual world. Thus, compared to the parents’ generation, adolescents, in addition to a generally positive picture of the world and high importance of the real world, also had more positive views of the virtual space and actively adapted to a mixed reality, which could act as a good psychological resource for adapting to major changes and shocks in the pandemic and the transition to distance learning.
Psychological factors of anti-vaccination behavior of Belarusians in the context of the COVID-19 pandemic
Authors:   Yanka Kupala State University of Grodno, Karpinski Konstantin
Published: January 2023

The article presents the results of a theoretical and empirical study of the psychological factors of refusal from preventive vaccinations against COVID-19 during an active campaign for mass vaccination of the population of Belarus. Among these factors, the individual characteristics of the subjective perception of the likelihood of infection, the severity of the course and consequences of coronavirus infection, as well as the effectiveness and safety of anticovid vaccination were considered; general attitudes in the field of vaccination and health care; and value attitudes towards health and life. The prevalence of the main categories of vaccination behavior — pro- and antivaccinational — was determined in the Belarusian population sample; the peculiarities of the cognitive assessment of COVID-19 and anticovid vaccination inherent in Belarusians, as well as their meaning-related determinants, were revealed; psychological differences between people with different directions of vaccination behavior are revealed; identified psychological predictors of antivaccination behavior. The empirical study was conducted on a representative population sample of residents of the Republic of Belarus (N=582, aged from 18 to 49 years, 178 men and 404 women), using questionnaire methods, as well as standardized personality questionnaires: “Scale of Basic Value”, “Scale of Healthcare Attitudes”, “Scale of Antivaccination Attitudes”. The results of the study indicate that generalized and nonspecific factors prevail in the regulation of the antivaccination behavior of Belarusians in the context of the coronavirus pandemic, which are associated with personal comprehension and cognitive assessment not so much of a new type of coronavirus infection and anti-vaccines offered to the population, but of the national healthcare system in general and vaccination as such. In this case, the leading factors and predictors of anti-vaccination behavior of Belarusians are general negative attitudes — anti-vaccination, anti-drug and anti-bureaucratic attitudes. In the course of the study, psychometrically developed and validated the original Russian-language “Scale of Antivaccination Attitudes”, designed to change the generalized negative-evaluative (skeptical-distrustful) attitude of the subject to vaccines and vaccination in general. The results obtained indicate the compliance of its measuring properties with conventional psychometric standards.
Empathy and attitude to uncertainty and risk-readiness in Russian doctors
Authors:   Lomonosov Moscow State University, Kryukova Ekaterina , Kornilova Tatiana ,   Lomonosov Moscow State University
Published: January 2023

One important part of the problem of medical uncertainty is the psychological profiles of doctors of different specialties, as well as the role of empathy in their activities. This article tests hypotheses about the specificity of the relationship between empathy and attitudes to- wards uncertainty and risk in the personal profile of doctors of different specialties and, in particular, among psychiatrists. Testing the Jefferson Scale of Empathy (JSE), we used: Medical Risk Scale; Budner’s Scale of Tolerance-Intolerance of Ambiguity, Personal decision-making factors (LFR-21), and the Dirty Dozen (DD) to identify the properties of the Dark Triad. The study involved 265 people: 112 doctors (Mage=36.8; SD=8.6), as well as 153 students who were also included in the JSE approbation. Samples of doctors included: 1) 46 psychiatrists in Moscow (Mage=38.4, SD=8.4), of whom 39 are women; 2) 66 doctors of other special- ties (Mage=41.01, SD=12.8), of which 37 are women. Doctors with expressed personal risk- readiness rated average riskiness for transferring a decision to another one lower, but at the same time, the average risk level when postponing a decision was higher. The Jefferson Scale of Empathy in a Russian-speaking sample of doctors showed a similar three-factor structure to the English-speaking sample. Empathy scales are associated with a positive attitude of doctors to uncertainty and risk, also with their risk assessments in medical decisions, and are included in the differentiation of latent profiles (in a sample of psychiatrists).
Intergenerational relationships as a factor of students’ psychological well-being: The moderation role of time perspective
Authors:   St. Petersburg State University, Strizhitskaya Olga , Petrash Marina ,   St. Petersburg State University
Published: January 2023

The work addresses the analysis of connections between indicators of intergenerational relations, time perspective and psychological well-being. The period of early adulthood is a period of self-determination, searching for meanings and setting goals for the future. Such transformations affect not only specific, but also integral mental characteristics, such as psychological well-being. The change in social roles that occurs at this age leads to the formation of new social ties, including complicating the system of intergenerational relations. At the same time, research shows that time perspective is associated with psychological well-being, while, as a rule, a positive assessment of perspective is positively associated with psychological well-being. Also, the time perspective is associated with intergenerational relationships. At the same time, there is no data on how these three constructs relate to each other. In our study, we grounded on the existing data and principles of development in ontogenesis, which led us to the idea that time perspective can mediate the strength of effect of intergenerational relationships on psychological well-being. The study sample consisted of 433 students of St Petersburg universities aged 17–24. For the study, we used: the scale of psychological well-being by C.Riff as adapted by L.V.Zhukovskaya, E.G.Troshikhina, Zimbardo Time Perspective Inventory (ZTPI), Intergenerational Social Relations Questionnaire (M.D.Petrash, O.Yu. Strizhitskaya). The analysis showed that intergenerational relationships, time perspective, and psychological well-being were closely related. Regression analysis refined these results by highlighting the component “personal growth” as the most closely associated with both intergenerational relationships and time perspective. Pathway structural modeling allowed us to see the mediation effect of time perspective. Thus, the results of our study allowed us to conclude that intergenerational relationships, time perspective and psychological well-being were connected, but also had the differentiated nature of these relationships. The theoretical significance of the results is that we showed the role of relationships with other generations and their effect on the psychological well-being of young people, that was mediated by the parameters of the time perspective. The practical significance of the work is related to the possibilities of psychological assistance in the formation and correction of the time perspective, taking into account the mechanisms obtained in the work.
On Water Synthesis of 3-Aryl-1,2,4-Triazolo[4,3-a]Pyridines Using
Iodobenzene Diacetate (IBD)
Authors: Aneja Deepak Kumar , Soni Rinku , Sihag Monika , Rani Neha , Kinger Mayank
Published: January 2023

An iodobenzene diacetate (IBD)-mediated simple and green method was determined for
the intramolecular oxidative cyclization of 3-aryl-2-pyridiylhydrazones of different aromatic
aldehydes in an aqueous medium at room temperature. This efficient strategy provides a route to
the synthesis of 3-aryl-1,2,4-triazolo[4,3-a]pyridines in water which eliminates the requirement to
use costly and unsafe volatile organic solvents. All reactions were carried out by just stirring the
reaction components in water at room temperature. This protocol provides a wide substrate scope
and good functional group tolerance.
A SAÚDE PREVENTIVA E A OBRIGATORIEDADE VACINAL COMO DIREITO DE TODOS, DEVER DO ESTADO E DE CADA CIDADÃO:
Authors: Bonizzato Luigi , Nehab Marcio Fernandes
Published: January 2023

A presente pesquisa objetiva examinar uma específica e direcionada relação entre determinados direitos fundamentais, como, de um lado, os relativos a liberdades e integridade física e, de outro, os relativos à vida, à saúde e ao bem-estar social. Entretanto, toda essa análise voltada para uma meta maior e grande cerne deste trabalho: o apontamento da relevância e magnitude da imunização pelo ato de vacinação, o qual deve, por meio de reforma à Constituição, tornar-se obrigatório no país. Nessa linha, o presente Artigo, além de explanar e teorizar, apresenta-se como propositivo, sobretudo ao expressamente trazer uma minuta, ou seja, um projeto de Proposta de Emenda à Constituição (PEC), a incidir sobre a Constituição do Brasil de 1988. Fez-se uso de método dedutivo analítico e, paralelamente, indutivo, a fim de que se pudesse chegar a novas conclusões e proposições, especialmente ligadas à vacinação. E isso, sem se esquecer de fazer menção à incidência e fenômeno nacional e global da Covid-19 e alguns de seus desdobramentos, sobretudo no Brasil. Exames técnicos-jurídicos e médicos, labutados e exibidos em convergência, embasaram o Artigo e as conclusões finais, segundo as quais deve ser obrigatória a vacinação, a partir do fornecimento de todas as condições à população, pelo Estado brasileiro.
IMPACTOS DA JUDICIALIZAÇÃO DA SAÚDE NOS DIREITOS DA PERSONALIDADE À LUZ DO CONSEQUENCIALISMO
Authors: Siqueira Dirceu Pereira , Santos Marcel Ferreira dos
Published: January 2023

O presente artigo tem por objetivo investigar em que medida a judicialização desenfreada da saúde pode impactar os direitos da personalidade e quais mecanismos e/ou filtros podem de ser utilizados, pelo Estado-Juiz, para adequação da tutela jurisdicional. Como problema de pesquisa, pretende-se discutir se o Estado-Juiz deve, ou não, por ocasião do silogismo judicial, levar em consideração as consequências práticas que as suas decisões podem provocar no seio social e nos direitos da personalidade. A tomada de decisão sobre quem irá experimentar prestação social de saúde não pode ser exercida com base em visão abstrata de tutela de direitos fundamentais sem examinar o custo da implementação desses direitos e o impacto orçamentário. O consequencialismo se insere, a partir da Lei de Introdução às Normas do Direito Brasileiro e Código de Ética da Magistratura Nacional, como componente legal apto a influir agentes estatais. Como percurso metodológico para o desenvolvimento do trabalho, utilizar-se-á do método hipotético-dedutivo. Aventa-se, como hipótese, a ser corroborada ou refutada ao longo da pesquisa, que o Poder Judiciário, com visão sentimentalista de tutela de direitos fundamentais, enfrenta lides envolvendo direito à saúde sem examinar as consequências práticas que suas decisões provocam no seio social, no orçamento público e na tutela de direitos da personalidade em geral. Como procedimento, objetiva-se o aprofundamento teórico por meio de pesquisa bibliográfica nas bases de dados da Scopus, EBSco e Google Acadêmico.
TABELA DE PROCEDIMENTOS DO SUS À LUZ DA ORDEM ECONÔMICA:
Authors: Machado Danyele da Silva , Lelis Davi Augusto Santana de , Clark Giovani
Published: January 2023

O trabalho tem como escopo questionar a política pública de saúde, acerca da remuneração das Santas Casas, quando da prestação complementar de serviços no âmbito do Sistema Único de Saúde, o qual utiliza valores unitários tabelados de procedimentos como parâmetro de cálculo da remuneração destas entidades filantrópicas. Nesta seara, expõe-se a problemática da ausência de correção inflacionária da tabela de procedimentos do SUS, como contraponto à essencialidade destas instituições no contexto das ações de saúde. Analisar-se-á esta faticidade a partir do Direito Econômico, mormente pelos ditames da ordem econômica constitucional, baseados na sua ideologia adotada, ensinada pelo Professor Washington Peluso Albino de Souza, os quais implicam a juridicização da política econômica aplicada. Examinar-se-á o entendimento doutrinário a respeito do tema, bem como a solução judicial para o fato, conforme o método analítico substancial, a fim de determinar a resposta jurídica para este embaraço econômico e contribuir para a manutenção da política pública e da relação fático-jurídica entre o Estado e a sociedade civil, como cumprimento do direito fundamental, social e humano que é a saúde, de forma democrática e cidadã.
The Relationship of Village Funds With Village Economic Development: A Village Level Study in Indonesia
Authors: Yusuf Mohamad , Khoirunurrofik Khoirunurrofik
Published: January 2023

The Village Fund Program is a manifestation of fiscal decentralization in Indonesia, which is intended to support equitable development and increase community welfare. The village government has the authority to plan the use of the Village Fund and to spend it concerning regulations from the central government. The use of the Village Fund needs to be evaluated to determine whether the funds have been spent properly and to support the village's economic development. This study aims to identify Village Fund program activities that can affect village economic development and determine regional priorities in utilizing Village Funds for village development in the economic field. The analysis was conducted using a qualitative approach by mapping and tagging Village Fund expenditures. The mapping and tagging aim to ensure that Village Fund spending follows the mandate and to know the composition of the share of economic spending in each region. The results showed that: (1) the utilization of the Village Fund was following the applicable priority guidelines for the use of the Village Fund; (2) the share of economic spending in the eastern part of Indonesia is lower than in other regions, but the trend is constantly rising, while the share of economic spending in the islands of Java and Bali shows a higher number. Based on the research results, this study suggests that villages in disadvantaged areas prioritize Village Fund spending for infrastructure improvement and regional openness to increase village progress or independence.
Исследование некоторых низкотемпературных характеристик пластификаторов на основе этиленгликоля
Authors: Путис С.М. , Мершин А.Ю. , Душенок С.А.
Published: January 2023

The results obtained by studying the low-temperature characteristics of diodes (ethylene glycol and its derivatives) and their nitroesters by the differential scanning calorimetry method are presented. It is shown that the studied compounds are characterized by glass transition temperatures in the range from -73 to -103oC, while ethylene glycol and its dinitrate differ from other compounds in the presence of crystallization and melting temperatures under experimental conditions.
Фоточувствительность полевого транзистора металл-диэлектрик-полупроводник на основе пленки PbSnTe:In с составом вблизи инверсии зон
Authors: Климов А.Э. , Ахундов И.О. , Голяшов В.А. , Горшков Д.В. , Ищенко Д.В. , Сидоров Г.Ю. , Пащин Н.С. , Супрун С.П. , Тарасов А.С. , Федосенко Е.В. , Терещенко О.Е.
Published: January 2023

A prototype of a metal–insulator–semiconductor field-effect transistor based on PbSnTe:In/(111)BaF2 film with an Al2O3 gate dielectric was designed for the first time. With the gate voltage applied in the range – 7.7 V < Ugate < +7.7 V the relative modulation in the drain-source current Ids/Ids attained near five-fold change at T = 4.2 K. When illuminated with rela-tively low (~100 photon/s) fluxes, negative photoconductivity was detected accompanied with a decrease in Ids by ~104 times and a simultaneous decrease in Ids by ~103 times or even more. The estimated detectivity was about 71016 cmHz0.5W-1 at a wavelength  about 25 micron with the accumulation time about 0.5 s. A qualitative model is discussed which assumes the ex-istence of deep traps and a photo-capacitance effect.
Ползучесть древесины, исследованная методами непрерывного наноиндентирования от нано- до макромасштаба
Authors: Головин Ю.И. , Гусев А.А. , Тюрин А.И. , Головин Д.Ю. , Васюкова И.А. , Юнак М.А.
Published: January 2023

The paper presents the results of creep measurement in common pine wood at different scales ranging from nano to macro by means of continuous nanoindentation. It is shown that wood structure elements pertaining to different scale levels make different contribution to steady creep rate.
Male fertility: a summary overview of the publications April – September 2022
Authors: Rogozin D. S.
Published: January 2023

The article provides an overview of the most significant publications on male infertility. The main selection criteria were the practical relevance of the article, as well as the impact factor of the journal it was published, according to the SCImago Journal Rank (SJR). As a result, a list of 10 papers published in Q2-Q3 (April — September) 2022 was formed. The summary overview includes articles on the following topics: role of coronavirus infection in disorders of spermatogenesis, efficacy of hormonal stimulation before surgical sperm extraction, therapy consequences of diabetes mellitus on progeny reproductive health, new methods for selecting spermatozoa in ICSI, the efficacy of antioxidants, the safety of vaccines against SARS-CoV-2, the importance of genetic tests and predictive factors for micro-TESE success.
Comparison of the Users’ Attitudes Toward Cannabidiol on Social Media Platforms: Topic Modeling Study
Authors: Li Yongjie , Yan Xiangyu , Wang Zekun , Ma Mingchang , Zhang Bo , Jia Zhongwei
Published: January 2023

Background

As one of the major constituents of the cannabis sativa plant, cannabidiol (CBD) is approved for use in medical treatment and cosmetics because of its potential health benefits. With the rapid growth of the CBD market, customers purchase these products, and relevant discussions are becoming more active on social media.

Objective

In this study, we aimed to understand the users’ attitudes toward CBD products in various countries by conducting text mining on social media in countries with different substance management policies.

Methods

We collected posts from Reddit and Xiaohongshu, conducted topic mining using the latent Dirichlet allocation model, and analyzed the characteristics of topics on different social media. Subsequently, a co-occurrence network of high-frequency keywords was constructed to explore potential relationships among topics. Moreover, we conducted sentiment analysis on the posts’ comments and compared users’ attitudes toward CBD products on Reddit and Xiaohongshu using chi-square test.

Results

CBD-related posts on social media have been rapidly increasing, especially on Xiaohongshu since 2019. A total of 1790 posts from Reddit and 1951 posts from Xiaohongshu were included in the final analysis. The posts on the 2 social media platforms, Reddit and Xiaohongshu, were categorized into 7 and 8 topics, respectively, by the latent Dirichlet allocation model, and these topics on the 2 social media were grouped into 5 themes. Our study showed that the themes on Reddit were mainly related to the therapeutic effects of CBD, whereas the themes on Xiaohongshu concentrated on cosmetics, such as facial masks. Theme 2 (CBD market information) and theme 3 (attitudes toward CBD) on Reddit had more connections with other themes in the co-occurrence network, and theme 3 and theme 1 (CBD therapeutic effects) had a high co-occurrence frequency (22,803/73,865, 30.87%). Meanwhile, theme 1 (CBD cosmetics) on Xiaohongshu had various connections with others (169,961/384,575, 44.19%), and the co-occurrence frequency of theme 4 (CBD ingredients) and theme 1 was relatively prominent (27,128/49,312, 55.01%). Overall, users’ comments tended to be positive for CBD-related information on both Reddit and Xiaohongshu, but the percentage was higher on Xiaohongshu (82.25% vs 86.18%; P<.001), especially in cosmetics and medical health care products.

Conclusions

The CBD market has grown rapidly, and the topics related to CBD on social media have become active. There are apparent differences in users’ attitudes toward CBD in countries with different substance management policies. Targeted CBD management measures should be formulated to suit the prevalence of CBD use of each country.
Electronic Medical Record System Use and Determinants in Ethiopia: Systematic Review and Meta-Analysis
Authors: Tegegne Masresha Derese , Wubante Sisay Maru , Kalayou Mulugeta Hayelom , Melaku Mequannent Sharew , Tilahun Binyam , Yilma Tesfahun Melese , Dessie Hiwote Simane
Published: January 2023

Background

The strategic plan of the Ethiopian Ministry of Health recommends an electronic medical record (EMR) system to enhance health care delivery and streamline data systems. However, only a few exhaustive systematic reviews and meta-analyses have been conducted on the degree of EMR use in Ethiopia and the factors influencing success. This will emphasize the factors that make EMR effective and increase awareness of its widespread use among future implementers in Ethiopia.

Objective

This study aims to determine the pooled estimate of EMR use and success determinants among health professionals in Ethiopia.

Methods

We developed a protocol and searched PubMed, Web of Sciences, African Journals OnLine, Embase, MEDLINE, and Scopus to identify relevant studies. To assess the quality of each included study, we used the Joanna Briggs Institute quality assessment tool using 9 criteria. The applicable data were extracted using Microsoft Excel 2019, and the data were then analyzed using Stata software (version 11; StataCorp). The presence of total heterogeneity across included studies was calculated using the index of heterogeneity I2 statistics. The pooled size of EMR use was estimated using a random effect model with a 95% CI.

Results

After reviewing 11,026 research papers, 5 papers with a combined total of 2439 health workers were included in the evaluation and meta-analysis. The pooled estimate of EMR usage in Ethiopia was 51.85% (95% CI 37.14%-66.55%). The subgroup study found that the northern Ethiopian region had the greatest EMR utilization rate (58.75%) and that higher (54.99%) utilization was also seen in publications published after 2016. Age groups <30 years, access to an EMR manual, EMR-related training, and managerial support were identified factors associated with EMR use among health workers.

Conclusions

The use of EMR systems in Ethiopia is relatively low. Belonging to a young age group, accessing an EMR manual, receiving EMR-related training, and managerial support were identified as factors associated with EMR use among health workers. As a result, to increase the use of EMRs by health care providers, it is essential to provide management support and an EMR training program and make the EMR manual accessible to health professionals.
ULTRASOUND-ASSISTED SYNTHESIS AND DOCKING STUDY OF NOVEL CHROMONE-THIADIAZOLE INTEGRATED PHOSPHONATE DERIVATIVES TARGETING TOPOISOMERASE II AS ANTICANCER AGENTS
Authors: CHIVTE VAISHNAVI K. , CHIVTE DHANASHREE KIRAN
Published: January 2023

Objective: The present studies discuss the anticancer activity of different topoisomerase II inhibitors with docking study.

Methods: The work reports the synthesis of novel diethyl (4-oxo-4H-chromen-3-yl)(5-substituted phenyl-1,3,4-thiadiazol-2-ylamino)methyl phosphonate derivatives 6(a-j). They were synthesized through one-pot three-component Kabachnik-Fields reaction by using ultrasonicator processor, at room temperature in presence of Zirconium oxychloride (ZrOCl2).

Results: The structures of the synthesized compounds were confirmed by spectral analysis. The synthesized derivatives 6(a-j) were evaluated for their in vitro anticancer activity against human cancer cell lines such as DU 145 (Human Prostate Cancer) and MCF-7 (Breast cancer) and also on non-tumor cell lines such as MCF-10 (normal breast epithelial cell) by MTT assay. From the anticancer screening results data, compound 6e was found to be the most potent anticancer compound among the synthesized compounds against MCF-7 and DU 145 cancer cell lines with IC50 value of 2.97 µM and 3.11 µM, respectively. The compound 6h has shown cell cycle arrest at G2/M phase, along with the decrease of cells at G0/G1 phage. The compound 6h was able to induce apoptosis in DU 145 cell lines. The synthesized compounds 6(a-j) were further evaluated for their topoisomerase II inhibitory activity.

Conclusion: The anticancer screening result and MTT assay, along with the docking study shows that the synthesised derivative are active anticancer agent against MCF-10, DU-145 and MCF-7 cell line.
INVESTIGATION ON THE INTERACTION OF β-SITOSTEROL AND LUTEOLIN-7-GLUCOSIDE BINDING TO BOVINE SERUM ALBUMIN
Authors: GARAD SUNIL VENKATRAO , SANGRAM PATIL SIDHESHWAR
Published: January 2023

Objective: The study ondrug–protein interactions is an important field of interest because of the prospective of unraveling of drug action mechanisms and the possibility of designing novel medicines. Bovine serum albumin (BSA) has been studied extensively because of its structural homology with human serum albumin (HSA). The objective of the work was to study the interaction between β-sitosterol and Luteolin–7-glucoside with bovine serum albumin (BSA) investigated by molecular docking.
Methods: Docking studies were carried out using a crystal structure of bovine serum albumin complexed with naproxen (pdb code-4OR0). Auto dock 4.2 was used to perform molecular docking. Ligands were found flexible during the docking process, and protein was kept rigid.
Results: Molecular docking studies revealed that the β-sitosterol can bind in the large hydrophobic cavity of BSA, mainly by the hydrophobic interaction but also by hydrogen bond interactions between the hydroxyl (OH) group of β-sitosterol to SER 488 with hydrogen bond distance of 2.1Å. Luteolin-7-glucoside molecule interact by hydrophobic interaction with LYS 431, ARG 427, ALA 193 amino acids of Bovine Serum Albumin. The amino acids ARG 458, ARG 435, ARG 185 are involved in forming a hydrogen bond with hydroxyl oxygens, carbonyl carbon of Luteolin-7-glucoside with hydrogen bond distance of 2.4, 2.3 and 1.9 Å, respectively.
Conclusion: Study indicated that hydrophobic and hydrogen bonding interactions were mostly responsible for albumin interaction. Further research of the pharmaceutical potential of plant molecules will be valuable for monitoring their biological functions.
ULOGA AGENCIJE ZA ENERGETIKU REPUBLIKE SRBIJE U REGULACIJI ENERGIJE IZ OBNOVLJIVIH IZVORA – STUDIJA SLUČAJA VETROPARK „ČIBUK 1“
Authors: Spasojevic Nenad
Published: January 2023

Poslednjih godina u svetu je sve veći trend rasta proizvodnje energije iz obnovljivih izvora. U tom procesu energetske tranzicije Republika Srbija, kao i ostale države Zapadnog Balkana u velikoj meri zaostaje za državama Evropske unije koje konstantno postavljaju nove optimistične ciljeve. Na putu evropskih integracija Republike Srbije stoji potreba da se uskladi pravni i institucionalni okvir kako bi se omogućila veća proizvodnja energije iz obnovljivih izvora, a samim tim i smanjila zavisnost od uglja i prekomernog zagađenja. Autor će zato u radu analizirati trenutno stanje procesa energetske tranzicije u Republici Srbiji, ali i ulogu koju u tom procesu ima Agencija za energetiku Republike Srbije koja je jedan od najznačajnijih regulatornih organa. Posebni fokus rada biće na ispitivanju toga kako ovo regulatorno telo utiče na proces izdavanja neophodnih licenci proizvođačima električne energije iz obnovljivih izvora, ali i kako utiče na formiranje cene električne energije. Primenom metode studije slučaja na primeru vetroparka Čibuk 1 biće analiziran tok razvoja vetroparka, kao i uloga Agencije za energetiku u tom procesu. Na kraju za sam proces energetske tranzicije važno pitanje je ispitati i kolika je zapravo korisnost i isplativost od pokretanja vetroparkova u Republici Srbiji.
STRATEGIJA RAZVOJA OPŠTINE RAKOVICA 2011 – 2020 GODINE
Authors: Divljak Milica
Published: January 2023

Predmet rada je lokalni ekonomski razvoj gradske opštine Rakovica, čiji su postulati sagledani kroz analizu Strategije razvoja opštine donete za period od 2011. do 2020. godine. Cilj rada je sagledanje pozitivnih i negativnih aspekata u procesu donošenja i implementacije Strategije, što će biti izvršeno kroz prikaz analize stanja po sektorima utvrđenih Strategijom kao i definisanih predloga i zadataka namenjenih poboljšanju stanja, potom i pregledom postignuća i identifikovanih problema. Teorijski okvir za razumevanje koncepta lokalnog ekonomskog razvoja, kao i određene karakteristike u primeni ovog koncepta u našoj državi, uz analizu Strategije i pregled postignuća doprinose uočavanju i adekvatnom razumevanju problema sa kojima se jedinice lokalne samouprave načelno susreću u Srbiji, ali i posebnih problema gradskih opština u Beogradu koje nisu određene kao jedinice lokalne samouprave, uz naglasak na slučaj gradske opštine Rakovica.
CRECIMIENTO ECONÓMICO, TIPO DE CAMBIO REAL Y EXPORTACIONES MANUFACTURERAS DE MÉXICO, 1998-2020
Authors: Castañeda Martínez Ana Erika , López González Teresa
Published: January 2023

El principal objetivo del artículo es comprobar empíricamente, para el caso de México en el periodo 1998-2020, la hipótesis central del enfoque neoestructuralista que sostiene la existencia de una relación positiva entre el tipo de cambio real y el crecimiento económico. Utilizamos un modelo de cointegración del tipo Engle y Granger. Exponemos hechos estilizados sobre los flujos comerciales que muestran algunas características de dichos flujos, los cuales permiten entender por qué en la economía mexicana no se registraron las derramas de la difusión tecnológica (spillovers from technology difussion) que, según la nueva teoría del comercio internacional, son inducidas por la liberalización comercial, más concretamente por las exportaciones de mercancías. Estos hechos estilizados contribuyen a la interpretación de los resultados del modelo de cointegración, así como a identificar algunos de los factores de la restricción externa al crecimiento en la economía mexicana (Thirlwall, 1979).
 
ECONOMIC GROWTH, REAL EXCHANGE RATE AND MEXICO’S MANUFACTURING EXPORTS, 1998-2020
ABSTRACT
The main objective of this article is to empirically test, for the case of Mexico over the period 1998-2020, the central hypothesis of the Neostructuralist approach, namely the existence of a positive relationship between the real exchange rate and economic growth. To this purpose, a cointegration model of the Engle and Granger type is used. Stylized facts about trade flows are presented showing some characteristics of the said flows, which allow us to understand why in the Mexican economy the spillovers of technological diffusion are not seen, spillovers which, according to the new international trade theory, are induced by trade liberalization, more specifically by merchandise exports. These stylized facts contribute to the interpretation of the results of the cointegration model as well as to identify some of the factors involved in the external constraints on the growth rate of the Mexican economy (Thirlwall, 1979).
A Home of Opportunity: Exploring the Real Issues Behind the Informal Housing Market in Developing Countries and Solutions to Tackle the Problem
Authors: Carrasco Lucia
Published: January 2023

Abstract: Based on the work of Hernando De Soto, this essay explores the chaotic housing situation in developing countries, the issues that contribute to this, and potential solutions. We ask: why do systems work in the West but not in developing countries? An analysis of the informal markets in these countries provides insight into this question and its implications.
Performance Evaluation of Selected Open-Ended Mutual Fund Schemes in India
Authors: Sharma Dr. Ishwar , Bharti  , Verma Bhawana , Saini Chanchal
Published: January 2023

Abstract: Mutual funds are considered as the best investment option because they offer a higher return with little risk. The study’s main aim is to evaluate the performance of selected large and small cap equity mutual fund schemes. The performance has been analysed in terms of return and risk using risk-adjusted performance measures. The present study is descriptive and secondary data has been collected from the website of BSE, NSE and Mutual funds. The analysis shows that “HDFC Top 100 Fund - Growth Option - Direct Plan” is top large cap mutual funds scheme and “Tata Small Cap Fund-Direct Plan-Growth” is top small cap mutual funds scheme among the selected funds as per Sharpe, Treynor and Jenson ratio.
Thyroid Disease Detection System
Authors: Sirohi Devansh , Kashyap Deepanshu , Pal Devendra , Goyal Gopal , Verma Bhumica
Published: January 2023

Abstract: This paper aims to recognize the diagnosis of the thyroid disease and then categorize the type of thyroid disease a patient may be suffering from (i.e., hyperthyroidism or hypothyroidism). The project implementation is being done by using python and Kaggle is the platform from which the dataset has been taken. At present many machine learning algorithms have been used to detect thyroid disease like but our goal is to implement the machine learning algorithm which has higher accuracy and which takes less time in detecting the disease along with the type of thyroid. We have trained the dataset taken from Kaggle over various machine learning techniques. We have also attempted to reduce the number of parameters required to detect the disease.
Review: Formulation Development of Liquid Dosage Form
Authors: Gupta Vishal , Sharma Surya Prakash , Chaurasia Deepak Kumar , Shukla Dr. Tarkeshwar P.
Published: January 2023

Abstract: Liquid dosage forms are generally found in medicines for aged and paediatrics patients. Though, they have specific advantages, along with fast efficacy due to the devoid of dissolution time and quick absorption in the stomach and intestines than tablets. Liquid formulations have been broadly used in pharmaceutics due to their high dosing adjustability, comfort of swallowing, and rapid onset of action.