bluuebunny/crossref_metadata_2025 huggingface dataset:
Tetrac as an anti-angiogenic agent in cancer
Authors: Schmohl Kathrin A , Nelson Peter J , Spitzweg Christine
Published: May 2019

The thyroid hormones T3 and T4 have emerged as pro-angiogenic hormones with important implications for cancer management. Endogenous circulating hormone levels may help stimulate cancer progression and limit the effectiveness of anticancer therapy, though clinical data remain inconclusive. The capacity of thyroid hormones to modulate angiogenesis is mediated through non-canonical mechanisms initiated at the cell surface receptor integrin αvβ3. This integrin is predominantly expressed on tumour cells, proliferating endothelial cells and tumour stroma-associated cells, emphasising its potential relevance in angiogenesis and tumour biology. Thyroid hormone/integrin αvβ3 signalling results in the activation of intracellular pathways that are commonly associated with angiogenesis and are mediated through classical pro-angiogenic molecules such as vascular endothelial growth factor. The naturally occurring T4 analogue tetrac blocks the pro-angiogenic actions of thyroid hormones at the integrin receptor, in addition to agonist-independent anti-angiogenic effects. Tetrac reduces endothelial cell proliferation, migration and tube formation through a reduction in the transcription of vascular growth factors/growth factor receptors, hypoxia-inducible factor-1α, pro-angiogenic cytokines and a number of other pro-angiogenic genes, while at the same time stimulating the expression of endogenous angiogenesis inhibitors. It further modulates vascular growth factor activity by disrupting the crosstalk between integrin αvβ3 and adjacent growth factor receptors. Moreover, tetrac disrupts thyroid hormone-stimulated tumour recruitment, differentiation and the pro-angiogenic signalling of tumour stroma-associated mesenchymal stem cells. Tetrac affects tumour-associated angiogenesis via multiple mechanisms and interferes with other cancer cell survival pathways. In conjunction with its low toxicity and high tissue selectivity, tetrac is a promising candidate for clinical application.
Vaspin in the pig ovarian follicles: expression and regulation by different hormones
Authors: Kurowska Patrycja , Mlyczyńska Ewa , Barbe Alix , Staub Christophe , Gregoraszczuk Ewa , Dupont Joëlle , Rak Agnieszka
Published: May 2019

Vaspin, also known as visceral adipose tissue-derived serine protease inhibitor, is a member of the serine protease inhibitor family. Its expression is associated with obesity, insulin resistance and type 2 diabetes, and elevated concentration is observed in polycystic ovary syndrome. However, vaspin has never been studied in the ovary. Here, we identified vaspin in two prolific breeds of pigs: fat Meishan (MS) and lean Large White (LW). We then investigated the molecular mechanism involved in the regulation of its expression in response to gonadotropins, insulin, insulin-like growth factor type 1 (IGF-1) and steroids (progesterone, testosterone and oestradiol) in ovarian follicles cells. Using real-time PCR and Western blot, we found higher vaspin mRNA and protein expression in the ovarian follicles and adipose tissue at 10–12 days of the oestrous cycle in MS compared to LW. Moreover, vaspin expression, as well as its concentration in plasma and follicular fluid, decreased in ovarian follicles of LW during days of the oestrous cycle, while the opposite results were noted in MS. Immunohistochemistry showed vaspin in granulosa, theca, cumulus cells and oocytes as well as in adipocytes. Vaspin level in the ovary increased by gonadotropin, insulin, IGF-1 and steroids stimulation through kinases JAK/Stat, ERK1/2, PI3K and AMPK, as well as factor NF-κB. These findings all show vaspin expression and regulation in the pig ovary, indicating vaspin as a new regulator in female reproduction. Future studies will be necessary for understanding the role of vaspin on ovarian physiology providing new insights into the pathology of ovaries.
PHILANTHROPY IN ANCIENT TIMES: SOCIAL AND EDUCATIONAL ASPECTS
Authors: AFTYKA LESZEK
Published: May 2019

The article presents the data of ancient times philanthropy that stemmed from community life and was a consequence of the social nature of man; in Rome, for the first time, social and educational activity was formalized, which resulted from moral and legal norms; in the Judaic religion, help to the needy was treated as one of the most important religious practices. The article discusses the most important forms of social aid in the Western antiquity. Charity, volunteering presented as important components of the social and educational activities of modern institutions. The author emphasizes the need for the formation and development of humanistic consciousness, spiritual and moral consciousness of citizens. Therefore, cooperation between educational institutions, families, non-governmental organizations, volunteer movements, charitable foundations for the expansion of active charitable activities, and the creation of a humanistic society is required.
Results of an Environmental Scan to Determine the Level of Uncorrected Refractive Error in First Nations Elementary School Children in Ontario
Authors: Chris A. Paul , Young Nancy L. , Belanger Kayla , Greasley Lyndsay
Published: May 2019

A survey was developed and used to determine the level and quality of vision care services available to First Nations elementary school children across Ontario, and to indirectly determine the level of uncorrected refractive error in First Nations children. Overall, the total survey results showed that 1 child in 4 wore glasses. The results from the survey indicated that remote communities that had a visiting optometrist were more likely to have fewer cases of uncorrected refractive error than non-remote communities. The results suggest that in-community comprehensive eye exams delivered on a regular basis by visiting optometrists would be the most effective way of improving the vision and eye health status of First Nations children.
Updating the Competency Profile and Examination Blueprint for Entry-Level Optometry in Canada
Authors: Cane David , Penny Margaret , Marini Anthony , Hynes Tami
Published: May 2019

The Optometry Examining Board of Canada (formerly Canadian Examiners in Optometry) is a not-for-profit corporation that administers the entry-to-practice examination for optometrists in Canada in service to its members, the 10 provincial optometry regulators.

 

The described work resulted in an updated entry-level competency profile for optometry, together with an examination blueprint based upon indicators derived from the competencies. The project took place over the period May 2014 – September 2015 and involved the following steps:

 

Establishment of project teams

Clarification of conceptual framework

Development of proposed competencies

Validation of competencies

Development of indicators for each competency, consistent with the assessment methodologies used in the entry-to-practice examination

Construction of an updated examination blueprint
Re-Envisioning the North: The Importance of Effective Cultural Planning for Economic Growth & Sustainability in Northwestern Ontario Rural Communities
Authors: Kukko Suzanne
Published: May 2019

Since the fall of the forestry industry over a decade ago, Northwestern Ontario has struggled to find its footing in an ever changing, global economy. As the hub of NWO, Thunder Bay has kept their economic engine fired through the facilitation of research and development, and by aggressively promoting itself as a travel destination. But without an anchor industry, research facilities, and major infrastructure, how will northern rural communities continue to sustain themselves? In today’s economic climate, diversification and sustainability must be achieved through attraction of creative talent. Peeling back the layers of the development happening within Nipigon, a small town 110 km east of Thunder Bay, we see that such a transformation is beginning to happen, although not by design. What is Nipigon already successfully doing to transform itself into a creative community? What deliberate actions should it take to achieve further success? Through the development and facilitation of a cohesive cultural planning strategy, Nipigon will be an evolutionary model for other northern rural communities experiencing similar economic challenges.Key Words: cultural planning, creative community, sustainability, arts, culture, north
The rise of the local food movement and its impact on rural economies: With examples from the Region of Durham
Authors: Jibb Stacey
Published: May 2019

Rural economies across North America continue to see the positive impacts of the rise of the local food movement and the evolution of the local food system. Local food is a fluid definition impacted by several factors. Government policy, geography and the personal relationships that develop between producer and consumer all play a part in shaping what is local. This has altered how consumers interact with the local food economy and has given rise to direct-farm marketing and agri-tourism as ways to participate in the local food system. Using examples from northern Durham Region, this paper examines how rural economies are impacted by the growing demand for access to local food and how that translates into direct impacts for the local economy. 

Keywords: local food, local food movement, rural economies, direct-farm marketing, food economy
Adult Tourniquet for Use in School-Age Emergencies
Authors: Harcke H. Theodore , Lawrence Luke L. , Gripp Emily W. , Kecskemethy Heidi H. , Kruse Richard W. , Murphy Stephen G.
Published: May 2019

BACKGROUND:

Gunshot injuries are a leading cause of morbidity and mortality in the pediatric population. The Pediatric Trauma Society supports the use of tourniquets for exsanguinating hemorrhage in severe extremity trauma. The Combat Application Tourniquet (CAT) used with success in adults has not been prospectively tested in children. Our objective with this study was to determine if the CAT is successful in arresting extremity arterial blood flow in school-aged children.

METHODS:

Sixty school-aged volunteers (ages 6–16 years) recruited by age cohort had the CAT applied to an upper arm and thigh while peripheral pulse was monitored by Doppler. The number of windlass turns (maximum allowed: 3 [1080°]) required to arrest arterial pulse was recorded. Success was analyzed by BMI percentile for age and extremity circumference.

RESULTS:

The CAT was successful in occluding arterial blood flow as detected by Doppler pulse in all 60 (100%) of the upper extremities tested. In the lower extremity, 56 (93%) had successful occlusion. The 3-turn maximum allowed by the protocol was not adequate in some obese, older subjects (BMI >30). In both the upper and lower extremity, the number of turns required to occlude blood flow gradually increased with an increase in arm and thigh circumference.

CONCLUSIONS:

Prospective testing of a cohort of school-aged children 6 to 16 years revealed the CAT tourniquet to be suitable for use in both the upper and lower extremity.
Behind Traditional Semi-quantitative Scores of Myocardial Perfusion Imaging: An Eye on Niche Parameters
Authors: Nappi Carmela , Gaudieri Valeria , Cuocolo Alberto
Published: May 2019

The evaluation of stress-induced myocardial perfusion defects by non-invasive myocardial perfusion imaging (MPI) modalities has a leading role in the identification of coronary artery disease, and has excellent diagnostic and prognostic value. Non-invasive MPI can be performed using conventional and novel gamma cameras or by PET/CT. New software has allowed novel parameters that may have a role in the identification of early marks of cardiac impairment to be evaluated. We aim to give an overview of niche parameters obtainable by single photon emission CT (SPECT) and PET/CT MPI that may help practitioners to detect initial signs of cardiac damage and identify new therapy targets. In particular, we summarise the role of left ventricular geometry indices for remodelling, phase analysis parameters to evaluate mechanical dyssynchrony, the concept of relative flow reserve in the evaluation of flow-limiting epicardial stenosis, vascular age and epicardial adipose tissue as early markers of atherosclerotic burden, and emerging parameters for the evaluation of myocardial innervation, such as the total defect score.
PENGELOLAAN BUDIDAYA RUMPUT LAUT BERBASIS DAYA DUKUNG LINGKUNGAN PERAIRAN DI PESISIR KABUPATEN DOMPU, PROVINSI NUSA TENGGARA BARAT
Authors: Yulius Yulius , Ramdhan Muhammad , Prihantono Joko , Gunawan Dino , Saepuloh Dani , Salim Hadiwijaya Lesmana , Rizaki I , Zahara R I
Published: May 2019

Rumput laut adalah alga makroskopik yang hidup di perairan, dan merupakan salah satu komoditas sumber daya pesisir dan laut cukup potensial karena memiliki nilai ekonomis yang tinggi, mudah dibudidayakan dan biaya produksi yang rendah. Perairan Kabupaten Dompu Provinsi Nusa Tenggara Barat (NTB) merupakan kawasan yang memiliki sumberdaya alam pesisir dan laut yang beraneka ragam, salah satunya dijadikan sebagai pengembangan budidaya rumput laut dengan jenis Eucheuma cottoni yang merupakan salah satu dari 5 jenis rumput laut yang dimanfaatkan di Indonesia. Tujuan dari penelitian ini adalah untuk mengetahui wilayah kesesuaian perairan budidaya rumput laut di Kabupaten Dompu serta mengestimasi daya dukung lingkungan perairannya. Penelitian ini menggunakan metode spasial dan nilai daya dukung lingkungan perairan berdasarkan unsur nutrien N dan P karena kedua unsur tersebut memiliki pengaruh terhadap kelangsungan budidaya rumput laut. Hasil penelitian kesesuaian perairan budidaya rumput laut diperoleh luasan sesuai sekitar 72.515 Ha atau 99,49 % dari luas total wilayah kawasan pengembangan. Hasil pendugaan daya dukung budidaya rumput laut long line untuk nilai produksi pada unsur N relative tinggi 0.7 ton/th, dengan masa panen selama 3-4 kali, dengan luas ruang perairan sebesar 15.219 Ha. Budidaya rumput laut yang telah dimanfaatkan saat ini seluas 500 Ha atau 3,3 % dari total luasan daya dukung, sehingga luasan yang belum termanfaatkan seluas 14.719 Ha atau 66,7 % dari total luasan daya dukung.
KUALITAS PERAIRAN TELUK KAYELI, KABUPATEN BURU, PROPINSI MALUKU, UNTUK BUDIDAYA LAUT DAN WISATA BAHARI
Authors: Rustam Agustin , Prabawa Fajar Y , Tussadiah Armyanda
Published: May 2019

Kualitas perairan merupakan salah satu faktor penting dalam mendukung usaha budidaya laut dan wisata bahari yang umumnya dilakukan di sebuah perairan teluk, seperti Teluk Kayeli yang terletak di Pulau Buru.  Penelitian ini bertujuan untuk menganalisis  kondisi perairan Teluk Kayeli yang dimanfaatkan sebagai lokasi kegiatan budidaya laut dan wisata bahari. Pengambilan sampel air dilakukan dengan menggunakan metode survei, dengan penentuan titik sampling secara sistematis di seluruh bagian dalam teluk pada bulan Oktober 2014. Hasil penelitian menunjukkan bahwa kualitas perairan di Teluk Kayeli masih sesuai baku mutu. Sebanyak 18 jenis fitoplankton dan 8 jenis zooplankton yang ditemukan. Kelimpahan rata-rata fitoplankton 51 sel/L dengan kelimpahan tertinggi jenis Chaetoceros decipiens. Berdasarkan analisis kualitas perairan Teluk Kayeli dinilai sesuai untuk budidaya keramba jaring apung dan wisata bahari, dengan nilai nitrat 0,006 mg/L, DO (dissolved oxygen) 5,89 mg/L, salinitas 33,26 PSU dan turbiditas 0,23 NTU. Hasil penelitian ini tidak mengukur kandungan logam berat dalam perairan sehingga disarankan agar dilakukan pengukuran logam berat terkait dengan masih adanya usaha penambangan yang membuang limbah ke sungai. Berdasarkan analisis kualitas perairan penelitian ini, Teluk kayeli sesuai untuk budidaya jaring apung maupun wisata bahari sehingga diperlukan infrastruktur ramah lingkungan yang mendukung, serta kajian daya dukung Teluk Kayeli untuk dua kegiatan tersebut.
Tempos históricos plurais: Braudel, Koselleck e o problema da escravidão negra nas Américas
Authors: Marquese Rafael de Bivar , Da Silva Júnior Waldomiro Lourenço
Published: May 2019

O artigo explora as interconexões entre as formulações de Fernand Braudel e Reinhart Koselleck a respeito do tempo histórico. Na primeira parte, após passarmos em revista os aspectos centrais do modelo braudeliano, procuramos demonstrar a forma como Koselleck se apropriou dele, renovando e radicalizando-o mediante um duplo procedimento de condensação e complexificação. Na segunda parte, por meio de um breve balanço historiográfico, exploramos as potencialidades da teorização braudel-koselleckiana no campo específico da escravidão negra nas Américas, expondo uma agenda de pesquisa renovada.
Cartas sobre o estudo e a utilidade da história
Authors: Bolingbroke Visconde de
Published: May 2019

Trechos selecionados e traduzidos por Arthur Alfaix Assis. Texto original em The Works of Lord Bolingbroke, Vol. II, Philadelphia: Carey andHart, 1841, p. 173-334.
Prevention, Monitoring, and Management of Cardiac Dysfunction in Patients with Metastatic Breast Cancer
Authors: Curigliano Giuseppe , Azambuja Evandro , Lenihan Daniel , Calabrò Maria Grazia , Cardinale Daniela , Cipolla Carlo Maria
Published: May 2019

Cardiac monitoring is becoming an important part of breast cancer care. Breast cancer and cardiovascular disease (CVD) share many common risk factors, and it is estimated that by the median age of diagnosis, many patients with breast cancer will have established or subclinical CVD. In addition, a number of treatments for metastatic breast cancer are known to have cardiac effects. As such, there is a clear need to prevent, identify, and effectively manage cardiovascular events in patients with breast cancer. Current clinical practice for patients with metastatic breast cancer involves a comprehensive set of assessments to ensure efficacy and safety of treatment. Adding cardiac monitoring to the assessments already required for patients with breast cancer may improve survival and quality of life. Currently, cardiac monitoring is recommended for several breast cancer treatments, and guidelines related to cardiac monitoring are available. Here, we review the risk of CVD in patients with breast cancer, providing an overview of the cardiac events associated with standard therapies for metastatic breast cancer. We also assess the current clinical recommendations relating to cardiac monitoring, and practical management strategies for oncologists. Cardio-oncology is a growing medical subspecialty that promotes the need for effective cancer therapy while minimizing cardiac effects. Integrating cardiac monitoring into routine clinical practice may safeguard patients with metastatic breast cancer against adverse cardiac effects.

Implications for Practice

This review details the common risk factors associated with cardiovascular disease that are frequently observed in patients with metastatic breast cancer, as well as the adverse cardiac effects of many therapies that are commonly prescribed. The review also provides a rationale for routine and comprehensive cardiovascular assessment of all patients at baseline, and during and after therapy depending on the treatment and presence of risk factors for cardiovascular disease. The medical discipline of cardio-oncology is increasingly being recognized as an important part of clinical practice to ensure effective cancer therapy while maintaining cardiac health.
Comparative lateral load field tests on straight-sided and belled piers in sloped ground
Authors: Qian Zeng-zhen , Lu Xian-long , Yang Wen-zhi
Published: May 2019

Comparative lateral load field tests were conducted on two straight-sided and two belled piers in a natural arid loess sloping ground with an inclination angle of 20° in the western Chinese Loess Plateau. The pier-head displacements, sloping ground surface deformations and soil pressure distributions were measured. The lateral load–displacement curves of the straight-sided and belled piers in the sloping ground generally exhibited the same three-phase non-linear behaviour, and their performances were similar to those of laterally loaded drilled shafts in horizontal ground. The ‘interpreted failure load’ of the laterally loaded piers in sloping ground was obtained using the representative lateral interpretation criteria and their extensions. Compared with the normalised lateral load–displacement curves of the drilled shafts in horizontal ground under drained and undrained lateral loadings, the displacement required to completely mobilise the lateral resistance for piers in sloping ground was much smaller. It was found that the use of belling can cause greater load transfer depths and can effectively mobilise more soil to resist lateral load. In addition, for both straight-sided and belled piers, an additional embedment of the shaft in sloping ground can increase lateral resistance to match the level-ground lateral capacity.
Improved one-phase model of uniform corrosion for predicting the volume of rust
Authors: Zhang Yanlong , Su Ray Kai Leung
Published: May 2019

One-phase models of rebar corrosion have been widely used by practising engineers to predict the volume of rust and the time to cracking of the concrete cover, but the models have only considered the deformation of concrete and not the deformation of steel or the rust layer. Neglecting the deformation of the rust layer may result in inaccurate predictions. This study therefore proposes an adjustment factor to take into account the effect of the deformation of the rust layer on predicting the volume of rust with a conventional one-phase model of uniform corrosion. Furthermore, the effects of the material properties of the rust layer and corrosion-induced expansive pressure on the adjustment factor are investigated. To avoid inaccurate predictions of the volume of rust, the proposed adjustment factor should be applied in the conventional one-phase model of corrosion when the Young's modulus of rust is less than 460 MPa.
Kabarcıklı Akışkan Yataklı Bir Reaktörde Isı Geçişini Etkileyen Parametrelerin İncelenmesi
Authors: ERBAŞ Oğuzhan
Published: May 2019

Akışkan yataklı kazanlar, konvansiyonel yakma sistemlerine

göre düşük kaliteli yakıtların değerlendirilmesi açısından ekonomik, teknolojik

ve çevreci olma özelliklerini taşımaktadır. Akışkan yatak teknolojisi, kömür,

biyokütle, endüstriyel ve evsel atıkları temiz, güvenli ve yüksek verimli bir

şekilde yakılabilmektedir. Bu bağlamda "akışkan yatakta yakma" nem ve

kükürt oranı yüksek linyitlerimizin değerlendirilmesinde, verimin artırılması

ve NOx, SO2 gibi zararlı emisyonların azaltılmasında

önemli bir seçenektir.

Akışkan yatakta, basınçlandırılan yakma havası ile yatak partikülünde

oluşturulan sürüklenme kuvveti ve yukarı yönde oluşan ortamsal kaldırma kuvveti

toplamı, aşağı yönde oluşan yatak partikül yerçekimi kuvvetleri ile

dengelenerek, yatak malzemesi kararsız yoğun türbülanslı ve sıvısal

hidrodinamik özellikli bir davranışa zorlanır. Bu davranış akışkan yatakta

hidrodinamiksel tasarımın ve ısı transfer mekanizmasının temelini oluşturur. Bu

çalışmada; kabarcıklı akışkan yataklı bir reaktörde daldırılmış yüzeyden ısı

geçişini belirleyen parametrelerin etkisi farklı test koşullarında deneysel

olarak incelenmiştir.
Calibration Protocol - Fluorescence Standard Curve with Fluorescein v1
Authors: Tennant Richard , Rutten Paul
Published: May 2019

Plate readers report fluorescence values in arbitrary units that vary widely from instrument to instrument. Therefore absolute fluorescence values cannot be directly compared from one instrument to another. In order to compare fluorescence output of test devices between teams, it is necessary for each team to create a standard fluorescence curve. Although distribution of a known concentration of GFP protein would be an ideal way to standardize the amount of GFP fluorescence in our E. coli cells, the stability of the protein and the high cost of its purification are problematic. We therefore use the small molecule fluorescein, which has similar excitation and emission properties to GFP, but is cost-effective and easy to prepare. (The version of GFP used in the devices, GFP mut3b, has an excitation maximum at 501 nm and an emission maximum at 511 nm; fluorescein has an excitation maximum at 494 nm and an emission maximum at 525nm). You will prepare a dilution series of fluorescein in four replicates and measure the fluorescence in a 96 well plate in your plate reader. By measuring these in your plate reader, you will generate a standard curve of fluorescence for fluorescein concentration. You will be able to use this to convert your cell based readings to an equivalent fluorescein concentration. Before beginning this protocol, ensure that you are familiar with the GFP settings and measurement modes of your instrument. You will need to know what filters your instrument has for measuring GFP, including information about the bandpass width (530 nm / 30 nm bandpass, 25-30 nm width is recommended), excitation (485 nm is recommended) and emission (520-530 nm is recommended) of this filter. Note: The iGEM Particle Standard Curve with Microspheres calibration method is a pre-requisite for carrying out this protocol. You will need data from that calibration to analyse the results of this protocol.
SOSYAL MEDYA VE YATIRIM ARAÇLARININ DEĞERİ ARASINDAKİ İLİŞKİNİN İNCELENMESİ: BITCOIN ÖRNEĞİ
Authors: POLAT Mustafa , AKBIYIK Adem
Published: May 2019

Sosyal medya, insanları alış
veriş alışkanlıklarından yatırım kararlarına kadar birçok ticari niyetleri
üzerinde yüksek etki düzeyi olduğu güncel birçok çalışmada araştırılmaya
başlanmıştır ve bu ilişki ortaya konmuştur. Bu ilişki üzerine inşa edilerek geliştirilen
güncel analiz yöntemleri yatırım araçlarının gelecek değerlerini tahmin ederek
yatırım kararları almada bir destek mekanizması olarak kullanılması çok cazip
bir konudur. Bu sebeple bu ilişki yatırımcı ve analistlerden akademisyenlere
kadar güncel bir ilgi konusu olmuştur.

 Bu çalışmanın amacı da sosyal medya ile
yatırım kararları arasındaki ilişkiyi metinsel ve finansal analiz aracılığı ile
görmeye çalışmaktır. Bu çalışmada Twitter üzerinden metin madenciliği ile veri
çekilmiş ve sentiment(duygu) analizi ile yorumların olumlu ya da olumsuz olma
durumu incelenmiştir. Sentiment analizinden elde edilen sayısal değerler ile
güncel ve küresel bir yatırım aracı olan Bitcoin fiyatları arasındaki ilişkinin
varlığını sorgulamak adına Granger Nedensellik analizi gibi finansal analizler
kullanılmıştır.
Contextual definitions and their applicability in the language of law
Authors: Ogleznev V. V.
Published: May 2019

Contextual definitions within the framework of modern logics and philosophy of science are widely used and explained. Moreover, they have acquired an independent epistemological meaning, along with other types of definitions. However, in the humanities, their applicability has been questioned and challenged many times. The author, on the contrary, substantiates the premise that the effectiveness of contextual definitions, in particular in the legal language, is not lower, and sometimes even much higher than the effectiveness of generic definitions. In a contemporary, especially western legal science, Bentham’s and Harts’s points of view that the contextual definition is opposed to the genetic definition continues to dominate, and the latter in relation to the analysis of legal concepts is recognized as ineffective and unproductive. The author is of the opinion that these two types of definitions may well coexist and in some sense complement each other, taking into account different areas of their applicability. The main and most characteristic area of application of contextual definitions, according to the author, are the constitutional rules of law. Constitutional rules of law in this approach are considered as contextual definitions of the basic concepts by which other rules of law in the legal system are formulated. Contextual definitions are very useful when we need to clarify the very general concepts and terms that can be found, for example, in the text of the Constitution. As a result, the defined terms become semantically meaningful, and their use in the legal language becomes syntactically consistent.
Category offense in theoretical and legal views of Aleksandr P. Kunitsyn
Authors: Egorov A. A.
Published: May 2019

The article is devoted to theoretical and legal views of Aleksandr P. Kunitsyn concerning the concept offense. The author analyzes the process of emergence of law and human rights as its type, in the context of which the right to perform acts is particularly highlighted. The paper examines the scholars’ views with regard to the concept, types, elements of the offense and the circumstances excluding criminality of the act. General theoretical ideas of Aleksandr P. Kunitsyn are compared with the views of his contemporaries — representatives of the science of criminal law — in order to determine the degree of their development. In conclusion, the stance of Aleksandr P. Kunitsyn concerning the issue of punishment is given. The author notes that Kunitsyn quite objectively and naturally describes the process of emergence of law within which he places emphasis on human rights. This emphasis is particularly relevant today. The division of human rights into primary and derivative is a perfectly correct guess that has been accepted by the legal science as a whole. Formulating the concept of an act inconsistent with the law, Aleksandr P. Kunitsyn uses neither “crime” nor “wrong.” However, the word “offense” used by him only within the framework of the general definition refers to the private law interpretation of a wrongful act. Classifications of types of offenses offered by him surpass classifications offered by his contemporaries — representatives of the science of criminal law — by definition, conciseness and depth of thought. This is a very rare phenomenon, since in most cases it is the developments of the criminal law doctrine that precede the actual general theoretical ideas. His views on careless form of guilt did not have analogues among researchers of the phenomenon of crime.
Sacred Spaces
Authors: Gonçalves José Fernando
Published: May 2019

The passage from sacred to secular space confers on religious space a wider functionality that will allow the incorporation of an abstract and open spatial symbolism to different perceptions of the divine to see, feel or invoke God. According to Rudolf Otto, on the Protestant churches the architectonic expression of the numinous is made by three fundamental elements of representation: obscurity, silence and emptiness. As elements that conceptually oppose the concrete or definitive symbol, they acquire a universal meaning that modern architecture itself will incorporate as a process of artistic emancipation.For a contemporary architect to design a religious space thus imposes an inevitable incursion into this Protestant matrix that appeals to the simplicity of forms, to the fidelity of construction and to the aesthetic experience as access to the transcendent. The mortuary chapels I am presenting takes up this contact with the modern constructive knowledge and with the return to the essential sacred place made of space, light and matter.
El acento católico
Authors: García-Lozano Rafael Ángel
Published: May 2019

El artículo comienza planteando la pregunta por la influencia protestante en la arquitectura religiosa católica contemporánea, abordada en algunos ámbitos territoriales, como el español, incluso de forma académica, y en publicaciones que han resultado referentes para la propia proyectación de iglesias en aquella época, y a la postre para el estudio y la investigación sobre este tema. A partir de este punto de partida, se analizan las influencias recibidas por la arquitectura religiosa contemporánea desde el ámbito protestante, tanto desde el punto de vista teológico como desde el meramente arquitectónico y constructivo, así como el papel llevado a cabo por otras influencias centroeuropeas relevantes. Finalmente el artículo desarrolla el acento aportado por la confesión católica a la arquitectura religiosa contemporánea a partir de las aportaciones tanto del Movimiento Litúrgico como más tarde del Concilio Vaticano II, poniendo de relieve el diálogo de éstas con las propuestas compartidas también por la Reforma.
Taller Templos Comunitarios
Authors: Bastías Gómez Freddy , Silva Gopfert Pablo
Published: May 2019

Para diseñar cualquier edificio sagrado, no basta con revisar la literatura: se requiere observar el rito de la vida, aun cuando no se comparta su fe. Por ello, el Taller Templos Comunitarios consideró diseñar templos y espacios de sociabilización para las comunidades luterana, musulmana y masónica, en el contexto de una carrera de arquitectura, en una universidad laica creada a partir de una disposición testamentaria que aleja la religión de sus aulas.Una experiencia en donde las comunidades hicieron las veces de mandante, pudiendo explorar sus posibilidades reales de edificar, mientras los estudiantes accedieron a observar y diseñar espacios para un rito que no practican. Todo en un ambiente alejado de proselitismos, diverso culturalmente, con diferencias de fe, asumiendo que el desafío común a todos los credos es diseñar un espacio que se ausenta del mundo para acoger los rituales más sagrados de la vida en comunidad.
Defining the Sacred
Authors: Crosbie Michael J.
Published: May 2019

How do we define what is sacred architecture? People of all ages are turning away from organized religion, and looking for a more genuine, personal experience of the spiritual. In considering sacred architecture, a distinction is whether architecture itself is sacred or that architecture is an instrument that calls forth the sacred. Distinctions should be drawn between situational versus substantive sacred space. A divine presence is believed to reside in substantive sacred space. In situational, anyplace can be sacred depending on the presence, location, and actions of human beings, often acting in community.Edward Anders Sovik was one of the most influential architects in the design of modern churches in the US. Active from the mid-20th-century through the 1970s, Sovik designed mostly Protestant churches and wrote extensively about church design and its liturgical underpinnings. Sovik believed that early Christians perceived themselves as a community of faith unattached to any place. His skepticism about the sacredness of buildings and objects sits squarely within Protestant theology. His religious architecture offers a good model for today, as the definition of sacred architecture is changing. Sovik’s emphasis on the secular and the sacred is prescient regarding the current state of religion and spirituality, and became the basis of a recent graduate design studio at Catholic University of America.
Competency of distal femur locking plate as an answer for fixation of all varieties of distal femur fractures
Authors: Medhi Mriganka Nagen , Mote Girish Balasaheb
Published: May 2019

Background: Distal femur fractures are common and need to be treated operatively and for optimal functional outcome. Multiple implants are available for fixation e.g. angled blade plate, dynamic condylar screw, buttress plate, antegrade nailing, retrograde nailing, locking distal femoral plates, external fixator etc. We have designed this study to analyse clinico-radiological outcome and competency of locked plating for all varieties of distal femur fractures.

Methods: We conducted a prospective interventional study on 79 consecutive patients with fractures of distal femur operated with locking distal femur plate from January 2015 to February 2018. Patients were regularly followed up with x-rays and clinical examination. At the end of clinicoradiological union, patients were evaluated with Neer’s score.

Results: Total 79 distal femur fractures were studied based on inclusion and exclusion criteria. There were 63 (79.75%) males and 16 (20.25%) females. As per AO classification fracture of type A were 39 (49.36%), type B were 10 (12.65%) and type C were 30  (37.97%). Average time period from injury to surgery was 8.2 days. In our study, the average period of clinicoradiological union was 16 weeks. 62 (78.48%) patients had excellent to satisfactory outcome, 13 (16.45%) patients had unsatisfactory and 4 (5.06%) patients had poor outcome.

Conclusions: Distal femur fractures are common, complex injuries and different implant option are available for fixation. All types of distal femur fractures can be fixed using distal femur locking compression plate. If fixed following basic principles of fracture fixation good results can be obtained.
BIOGRAPHICAL RESEARCH AND PUBLIC SECTOR ACCOUNTING LECTURERS
Authors: Yuhertiana Indrawati , Andre Purwanugraha Heribertus , Andayani Sari , Andhaniwati Erry , Denhas Kiki Nuriska
Published: May 2019

Purpose of Study: This research aims to understand the self learning process among accounting lecturers in mastering public sector accounting.

Methodology: The present study has been carried out a qualitative approach within the interpretive paradigm using biographical research. By employing thematic analysis, it was scrutinized 41 curriculum vitae of accounting lecturers. It focussed on education background, work experience, training, and publication related to public sector knowledge.

Main Findings: This research showed that the mastery of public sector accounting is learned by the formal and non-formal education, teaching activities and community services. Ontologically, this study is built on a belief that based on Bloom’s learning theory the effort of accounting educator could explain as lifelong learning in improving their cognitive, affective and pshychomotoric ability.

Implications/Applications: Efforts public sector accounting faculty to master public sector accounting mapped to cognitive, affective and psychomotoric. Strengthening the cognitive aspect is done through formal and non formal education. Some lecturers who do not gain knowledge of public sector accounting from formal education to look through non-formal education in a variety of training activities, workshops and seminars. Basic self learning theory and assumptions andragogy as adult learners who are motivated internally reinforce this fact.
Laparoskopi veya laparatomi ile histerektomi uygulanan hastaların postoperatı̇f vajı̇nal uzunluk ve kaf hematomu yönünden karşılaştırılması
Authors: Şimşek Erkan , Kadiroğulları Pınar , SEÇKİN Kerem Doğa , KARAASLAN Onur , KIYAK Hüseyin , Yıldırım Gökhan
Published: May 2019

Amaç:
Benign
endikasyonlar nedeniyle yapılan laparoskopik ve laparotomik histerektomi
ameliyatları sonrası, postoperatif vajinal uzunluk değerlerinin ve kaf hematomu
oluşma riskinin belirlenerek, operasyon tekniğine göre karşılaştırılması
amaçlanmıştır. Gereç
ve Yöntemler: Ocak
2017 - Ocak 2018 tarihleri arasında beningn endikasyonlar ile total laparoskopik
histerektomi (TLH) ve total abdominal histerektomi (TAH) yapılan 267 hasta
değerlendirildi. Hastaların operasyon öncesi demografik özellikleri, probe
küretaj sonuçları, smear sonuçları, geçirilmiş ameliyatları ve kronik
hastalıklarıyla ilgili bilgileri kaydedildi. Hastalar histerektomi sonrası 1.
ve 2. gün kontrolleri yapılarak taburcu edildiler. Postoperatif 7. gün kontrole
çağrılarak transvajinal ultrason ile kaf hematomu varlığı değerlendirildi ve
hastaların hegar bujisi yardımı ile histerektomi sonrası vajinal uzunlukları
ölçüldü. Bulgular:
Çalışmada kalan
200 hastayı içeren iki grup
arasında yaş, gravida, parite, geçirilmiş operasyon öyküsü, kronik hastalık
hikayesi gibi demografik özellikler arasında anlamlı fark saptanmadı. TLH olan
hastalarda tedaviye dirençli menometroraji 44 (%44) en sık saptanan operasyon
endikasyonu iken, TAH olan hastalarda myoma uteri 96 (%96) en sık endikasyon
olarak saptandı. Histerektomi sonrası vajinal uzunluk, TLH grubunda 6,35±0.81
cm, TAH grubunda 6.73±0.92 cm olarak hesaplanmış olup, iki grup arasındaki fark
istatiksel olarak anlamlı izlenmiştir (p=0.002).Kaf hematomu varlığı
değerlendirildiğinde, TLH grubunda 14 hasta, TAH grubunda 18 hastada
saptanmış olup, gruplar arasında anlamlı fark izlenmemiştir.

Sonuç:
Histerektomi
olan hastalarda postoperatif dönemde vajen kafında hematom gelişiminin
operasyon şeklinden etkilenmediği ve ayrıca preoperatif dönemdeki demografik
hasta özelliklerinin operasyon şekline çok büyük etkide bulunmadığı
gözlenmektedir. TLH yapılan hastalarda postoperatif vajinal uzunluk, TAH
yapılan hastalara kıyasla daha kısa olarak izlenmektedir. Ancak, hastanın
postoperative vajinal uzunluk ölçümü ikinci planda değerlendirilebilen bir
kriter olup öncelikle preoperative endikasyonlar ve minimal invaziv cerrahiye
uygunluğu gözetilerek cerrahi seçeneği belirlenmelidir.
The effect of work stress on the performance of employees psychological well-being and subjective well-being (Study at PT. Global Insight Utama Bali area)
Authors: Tsalasah Ekromi Fraida , Noermijati Noermijati , Ratnawati Kusuma
Published: May 2019

This study aimed to analyze the effect of work stress on employee performance, analyze the effect of work stress on psychologicall well-being, to analyze the influence of psychologicall well-being of the employee's performance, analyze the effect of work stress on subjective well-being, to analyze the influence of subjective well-being of the performance employee, psychologicall To analyze the effect of well-being as mediation work stress on employee performance, and analyze the influence of subjective well-being as mediation work stress on employee performance. Mechanical analysis using PLS. The analysis showed that the effect of work stress on employee performance, job stress affect the well-being psychologicall, psychologicall well-being affect the performance of the employee
The effect of commitment, leadership and compensation on job satisfaction and performance of government apparatus in West Sulawesi Province
Authors: Atika Atika , Modding Basri , Sammaila Baharuddin , Hafied Hamzah
Published: May 2019

The apparatus performance is a fundamental problem affecting the organizational performance of West Sulawesi Province Government. Many factors affect it, both individual characteristics and organizational, especially commitment, leadership, compensation and job satisfaction. This study analyzes the effect of organizational commitment, leadership and compensation on job satisfaction and the impact on apparatus performance. The study was conducted on 358 respondents of Government apparatus in West Sulawesi Province. The data was collected by five point Likert scale and analyzed by Structural Equation Model (SEM). The study results found that commitment and leadership affect on job satisfaction and apparatus performance. While compensation only affects job satisfaction and does not affect on performance apparatus.
Healthy Birth Practice #2: Walk, Move Around, and Change Positions Throughout Labor
Authors: Ondeck Michele
Published: May 2019

Women who use upright positions and are mobile during labor have shorter labors, less intervention, fewer cesarean births, and report less severe pain, and describe more satisfaction with their childbirth experience than women in recumbent positions. The evidence for supporting physiologic childbearing for optimal birth fails to disrupt intervention intensive hospital practices that deny 60% of women mobility in labor despite calls by maternity care organizations to not restrict mobility for low risk women in spontaneous labor.
Healthy Birth Practice #3: Bring a Loved One, Friend, or Doula for Continuous Support
Authors: Green Jeanne , Hotelling Barbara A.
Published: May 2019

All women should be allowed and encouraged to bring a loved one, friend, or doula to their birth without financial or cultural barriers. Continuous labor support offers benefits to mothers and their babies with no known harm.
POSTMORTEM CHANGES IN COLOR AND TRANSPARENCY OF TEETH AND THEIR FORENSIC VALUE
Authors: Manin A. I. , Barinov E. H. , Romodanovskiy P. O.
Published: May 2019

In this work the changing of shades of color and transparency of teeth was researched using computer technology. Dynamic postmortem changes of teeth and dentoalveolar fragments were researched throughout the 90 days.
POLYMORPHISM OF SEVEN MICROSATELLITE STR-LOCI INCLUDED IN THE STANDARD SET CODIS, ESS AND ISSOL FOR THE NATIVE POPULATION OF THE REPUBLIC OF ARMENIA
Authors: Bisharyan M. S. , Arutyunyan D. N. , Bagdasaryan M. R. , Sargsyan A. L.
Published: May 2019

The aim of the work was to study polymorphism of microsatellite STR loci vWA, CSF1PO, TPOX, TH01, D16S539, D13S317, D7S820 included in CODIS, ESS and ISSOL standard core loci for Armenian population. Correspondence of frequencies of examined loci to the Hardy – Weinberg equilibrium was revealed. To distinguish genetic variability of STR loci we examined vWA, CSF1PO, TPOX, TH01, D16S539, D13S317, D7S820STR loci of Armenian population residing in the territory of Armenia and compared with data of Caucasian-American population presented in the Promega Technical Manual Allele Frequencies for Caucasian-Americans protocol. This comparative study revealed significant differences for tested populations. The results indicate that this set of polymorphic STR loci provides some polymorphic information. Therefore, prior to the usage of new DNA markers included in CODIS, ESS and ISSOL standard core loci into forensic casework, as well as DNA paternity and relationship testing, studies should be performed on Armenian populationto establish polymorphism of microsatellite STR loci specific for Armenian population.
DETERMINATION OF PLACES OF ADMISSION OF MEDICAL CARE DEFECTS
Authors: Giyasov Z. A. , Islamov Sh. E.
Published: May 2019

The article is devoted to determination of places of admission of medical care defects. The purpose of the study was to determine the defects of medical care in the context of institutions, among specialists in various fields, by the nature and causes of occurrence. The material of the study was the findings of the commission of forensic medical examinations about professional offenses of medical workers conducted in all forensic institutions of the Republic of Uzbekistan. With a comprehensive multivariate analysis of the data obtained, logical, dialectical, comparative methods were used, as well as the collection and study of individual facts, monographic descriptions and statistical methods. It was revealed that medical care defects were mostly committed at the stage of hospitalization in central regional hospitals, emergency medical care units and at the stage before hospitalization in rural medical aid stations and polyclinics. Among medical specialties the defects were more often revealed in the work of obstetricians-gynecologists, surgeons, pediatrists, etc. The defects in diagnosis and treatment were prevailing and they developed due to subjective causes. The data concerning medical localizations were the defects were committed, taking into consideration specialties, essence and causes of development, were presented.
INTERNATIONAL CONGRESS “THE TOPICAL ISSUES OF FORENSIC MEDICINE AND EXPERT PRACTICE – 2019”
Authors: Klevno V. A.
Published: May 2019

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Serviços de descoberta: panorama nas bibliotecas das instituições públicas de ensino superior brasileiras
Authors: Almeida Fernanda Gomes , Cendón Beatriz Valadares
Published: May 2019

Este trabalho visa apresentar os contextos, conceitos, vantagens e limitações das principais abordagens para tornar os recursos das bibliotecas visíveis e acessíveis aos usuários como os catálogos online e os produtos de descoberta - interfaces ou ferramentas que têm um único ponto de entrada para todos os recursos da biblioteca, simplificando a consulta dos seus acervos físicos e online. Teve também por objetivo verificar se as bibliotecas em instituições públicas de ensino superior brasileiras têm aderido ao uso dos serviços de descoberta em escala para uma maior visibilidade dos seus acervos físicos e online, adaptando-se aos interesses da “geração Google”. A metodologia consistiu da identificação das instituições públicas de ensino superior por meio do Sistema e-MEC e da consulta aos sites das bibliotecas ou sistemas de bibliotecas das instituições identificadas visando apontar aquelas que utilizam os serviços de descoberta em escala na web. A pesquisa demonstrou que, embora promissores, os serviços de descoberta na web ainda não são uma realidade para a maioria das bibliotecas de instituições públicas universitárias brasileiras apresentando reflexões sobre as razões para a baixa taxa de adesão.