bluuebunny/crossref_metadata_2025 huggingface dataset:
Enzyme replacement therapy with taliglucerase alfa: 36‐month safety and efficacy results in adult patients with Gaucher disease previously treated with imiglucerase
Authors: Pastores Gregory M. , Shankar Suma P. , Petakov Milan , Giraldo Pilar , Rosenbaum Hanna , Amato Dominick J. , Szer Jeffrey , Chertkoff Raul , Brill‐Almon Einat , Zimran Ari
Published: April 2016

Taliglucerase alfa is the first available plant cell‐expressed human recombinant therapeutic protein. It is indicated for treatment of patients with type 1 Gaucher disease (GD) in adult and pediatric patients in several countries. Study PB‐06‐002 examined the safety and efficacy of taliglucerase alfa for 9 months in patients who previously received imiglucerase. The results of adult patients from Study PB‐06‐002 who continued receiving taliglucerase alfa in extension Study PB‐06‐003 for up to 36 months are reported here. Eighteen patients received at least one dose of taliglucerase alfa in Study PB‐06‐003; 10 patients completed 36 total months of therapy, and four patients who transitioned to commercial drug completed 30–33 months of treatment. In patients who completed 36 total months of treatment, mean percent (±standard error) changes from baseline/time of switch to taliglucerase alfa to 36 months were as follows: hemoglobin concentration, −1.0% (±1.9%; n = 10); platelet count, +9.3% (±9.8%; n = 10); spleen volume measured in multiples of normal (MN), −19.8% (±9.9%; n = 7); liver volume measured in MN, +0.9% (±5.4%; n = 8); chitotriosidase activity, −51.5% (±8.1%; n = 10); and CCL18 concentration, −36.5 (±8.0%; n = 10). Four patients developed antidrug antibodies, including one with evidence of neutralizing activity in vitro. All treatment‐related adverse events were mild or moderate and transient. The 36‐month results of switching from imiglucerase to taliglucerase alfa treatment in adults with GD provide further data on the clinical safety and efficacy of taliglucerase alfa beyond the initial 9 months of the original study. www.clinicaltrials.gov identifier NCT00705939. Am. J. Hematol. 91:661–665, 2016. © 2016 Wiley Periodicals, Inc.
Respiratory system involvement in Costello syndrome
Authors: Gomez‐Ospina Natalia , Kuo Christin , Ananth Amitha Lakshmi , Myers Angela , Brennan Marie‐Luise , Stevenson David A. , Bernstein Jonathan A. , Hudgins Louanne
Published: April 2016

Costello syndrome (CS) is a multisystem disorder caused by heterozygous germline mutations in the HRAS proto‐oncogene. Respiratory system complications have been reported in individuals with CS, but a comprehensive description of the full spectrum and incidence of respiratory symptoms in these patients is not available. Here, we report the clinical course of four CS patients with respiratory complications as a major cause of morbidity. Review of the literature identified 56 CS patients with descriptions of their neonatal course and 17 patients in childhood/adulthood. We found that in the neonatal period, respiratory complications are seen in approximately 78% of patients with transient respiratory distress reported in 45% of neonates. Other more specific respiratory diagnoses were reported in 62% of patients, the majority of which comprised disorders of the upper and lower respiratory tract. Symptoms of upper airway obstruction were reported in CS neonates but were more commonly diagnosed in childhood/adulthood (71%). Analysis of HRAS mutations and their respiratory phenotype revealed that the common p.Gly12Ser mutation is more often associated with transient respiratory distress and other respiratory diagnoses. Respiratory failure and dependence on mechanical ventilation occurs almost exclusively with rare mutations. In cases of prenatally diagnosed CS, the high incidence of respiratory complications in the neonatal period should prompt anticipatory guidance and development of a postnatal management plan. This may be important in cases involving rarer mutations. Furthermore, the high frequency of airway obstruction in CS patients suggests that otorhinolaryngological evaluation and sleep studies should be considered. © 2016 Wiley Periodicals, Inc.
Two cases of RIT1 associated Noonan syndrome: Further delineation of the clinical phenotype and review of the literature
Authors: Milosavljević Doris , Overwater Eline , Tamminga Saskia , de Boer Karin , Elting Mariet W. , van Hoorn Marion E. , Rinne Tuula , Houweling Arjan C.
Published: April 2016

Mutations in RIT1, involved in the RAS‐MAPK pathway, have recently been identified as a cause for Noonan syndrome. We present two patients with Noonan syndrome caused by a RIT1 mutation with novel phenotypic manifestations, severe bilateral lower limb lymphedema starting during puberty, and fetal hydrops resulting in intrauterine fetal death, respectively. Including our patients, a total of 52 patients have been reported with Noonan syndrome caused by a RIT1 mutation. Our report contributes to the delineation of the phenotype associated with RIT1 mutations and underlines that lymphatic involvement is part of this spectrum. In addition, we provide an overview of the currently described Noonan syndrome patients with RIT1 mutations in literature. © 2016 Wiley Periodicals, Inc.
Confirmation of TENM3 involvement in autosomal recessive colobomatous microphthalmia
Authors: Chassaing Nicolas , Ragge Nicola , Plaisancié Julie , Patat Oliver , Geneviève David , Rivier François , Malrieu‐Eliaou Claudie , Hamel Christian , Kaplan Josseline , Calvas Patrick
Published: April 2016

Anophthalmia and microphthalmia are the most severe malformations of the eye, referring to a congenital absence, and a reduced size of the eyeball respectively. More than 20 genes have been shown to be mutated in patients with syndromic and non‐syndromic forms of anophthalmia–microphthalmia. In a recent study combining autozygome and exome analysis, a homozygous loss of function mutation in TENM3 (previously named ODZ3) was reported in two siblings with isolated bilateral colobomatous microphthalmia from a consanguineous Saudi family. Herein, we report a third patient (not related to the previously reported family) with bilateral colobomatous microphthalmia and developmental delay in whom genetic studies identified a homozygous TENM3 splicing mutation c.2968‐2A>T (p.Val990Cysfs*13). This report supports the association of TENM3 mutations with colobomatous microphthalmia and expands the phenotypic spectrum associated with mutations in this gene. © 2016 Wiley Periodicals, Inc.
Molecularly Regulated Reversible DNA Polymerization
Authors: Chen Niancao , Shi Xuechen , Wang Yong
Published: April 2016

Natural polymers are synthesized and decomposed under physiological conditions. However, it is challenging to develop synthetic polymers whose formation and reversibility can be both controlled under physiological conditions. Here we show that both linear and branched DNA polymers can be synthesized via molecular hybridization in aqueous solutions, on the particle surface, and in the extracellular matrix (ECM) without the involvement of any harsh conditions. More importantly, these polymers can be effectively reversed to dissociate under the control of molecular triggers. Since nucleic acids can be conjugated with various molecules or materials, we anticipate that molecularly regulated reversible DNA polymerization holds potential for broad biological and biomedical applications.
Thermally Induced Silane Dehydrocoupling on Silicon Nanostructures
Authors: Kim Dokyoung , Joo Jinmyoung , Pan Youlin , Boarino Alice , Jun Yong Woong , Ahn Kyo Han , Arkles Barry , Sailor Michael J.
Published: April 2016

Organic trihydridosilanes can be grafted to hydrogen‐terminated porous Si nanostructures with no catalyst. The reaction proceeds efficiently at 80 °C, and it shows little sensitivity to air or water impurities. The modified surfaces are stable to corrosive aqueous solutions and common organic solvents. Octadecylsilane H3Si(CH2)17CH3, and functional silanes H3Si(CH2)11Br, H3Si(CH2)9CH=CH2, and H3Si(CH2)2(CF2)5CF3 are readily grafted. When performed on a mesoporous Si wafer, the perfluoro reagent yields a superhydrophobic surface (contact angle 151°). The bromo‐derivative is converted to azide, amine, or alkyne functional surfaces via standard transformations, and the utility of the method is demonstrated by loading of the antibiotic ciprofloxaxin (35 % by mass). When intrinsically photoluminescent porous Si films or nanoparticles are used, photoluminescence is retained in the grafted products, indicating that the chemistry does not introduce substantial nonradiative surface traps.
Benzimidazobenzothiazole‐Based Bipolar Hosts to Harvest Nearly All of the Excitons from Blue Delayed Fluorescence and Phosphorescent Organic Light‐Emitting Diodes
Authors: Cui Lin‐Song , Kim Jong Uk , Nomura Hiroko , Nakanotani Hajime , Adachi Chihaya
Published: April 2016

Much effort has been devoted to developing highly efficient organic light‐emitting diodes (OLEDs) that function through phosphorescence or thermally activated delayed fluorescence (TADF). However, efficient host materials for blue TADF and phosphorescent guest emitters are limited because of their requirement of high triplet energy levels. Herein, we report the rigid acceptor unit benzimidazobenzothiazole (BID‐BT), which is suitable for use in bipolar hosts in blue OLEDs. The designed host materials, based on BID‐BT, possess high triplet energy and bipolar carrier transport ability. Both blue TADF and phosphorescent OLEDs containing BID‐BT‐based derivatives exhibit external quantum efficiencies as high as 20 %, indicating that these hosts allow efficient triplet exciton confinement appropriate for blue TADF and phosphorescent guest emitters.
Selective Dynamic Assembly of Disulfide Macrocyclic Helical Foldamers with Remote Communication of Handedness
Authors: Tsiamantas Christos , de Hatten Xavier , Douat Céline , Kauffmann Brice , Maurizot Victor , Ihara Hirotaka , Takafuji Makoto , Metzler‐Nolte Nils , Huc Ivan
Published: April 2016

Disulfide bridge formation was investigated in helical aromatic oligoamide foldamers. Depending on the position of thiol‐bearing side chains, exclusive intramolecular or intermolecular disulfide bridging may occur. The two processes are capable of self‐sorting, presumably by dynamic exchange. Quantitative assessment of helix handedness inversion rates showed that bridging stabilizes the folded structures. Intermolecular disulfide bridging serendipitously yielded a well‐defined, C2‐symmetrical, two‐helix bundle‐like macrocyclic structure in which complete control over relative handedness, that is, helix–helix handedness communication, is mediated remotely by the disulfide bridged side chains in the absence of contacts between helices. MM calculations suggest that this phenomenon is specific to a given side chain length and requires disulfide functions
Alkali Metal Carbenoids: A Case of Higher Stability of the Heavier Congeners
Authors: Molitor Sebastian , Gessner Viktoria H.
Published: April 2016

As a result of the increased polarity of the metal–carbon bond when going down the group of the periodic table, the heavier alkali metal organyl compounds are generally more reactive and less stable than their lithium congeners. We now report a reverse trend for alkali metal carbenoids. Simple substitution of lithium by the heavier metals (Na, K) results in a significant stabilization of these usually highly reactive compounds. This allows their isolation and handling at room temperature and the first structure elucidation of sodium and potassium carbenoids. The control of stability was used to control reactivity and selectivity. Hence, the Na and K carbenoids act as selective carbene‐transfer reagents, whereas the more labile lithium systems give rise to product mixtures. Additional fine tuning of the M−C interaction by means of crown ether addition further allows for control of the stability and reactivity.
Base‐Free Conditions for Rhodium‐Catalyzed Asymmetric Arylation To Produce Stereochemically Labile α‐Aryl Ketones
Authors: Dou Xiaowei , Lu Yixin , Hayashi Tamio
Published: April 2016

The asymmetric arylation of 2,2‐dialkyl cyclopent‐4‐ene‐1,3‐diones with aryl boronic acids was found to be efficiently catalyzed by a chiral diene–rhodium μ‐chloro dimer, [{RhCl((R)‐diene*)}2], in the absence of bases in toluene/H2O to give 2,2‐dialkyl 4‐aryl cyclopentane‐1,3‐diones in high yields with high enantioselectivity. Such compounds can not be obtained with high enantiomeric purity under the standard basic conditions used for rhodium‐catalyzed asymmetric arylation because the α‐aryl ketone products undergo racemization under the basic conditions.
Pressure‐Dependent Polymorphism and Band‐Gap Tuning of Methylammonium Lead Iodide Perovskite
Authors: Jiang Shaojie , Fang Yanan , Li Ruipeng , Xiao Hai , Crowley Jason , Wang Chenyu , White Timothy J. , Goddard William A. , Wang Zhongwu , Baikie Tom , Fang Jiye
Published: April 2016

We report the pressure‐induced crystallographic transitions and optical behavior of MAPbI3 (MA=methylammonium) using in situ synchrotron X‐ray diffraction and laser‐excited photoluminescence spectroscopy, supported by density functional theory (DFT) calculations using the hybrid functional B3PW91 with spin‐orbit coupling. The tetragonal polymorph determined at ambient pressure transforms to a ReO3‐type cubic phase at 0.3 GPa. Upon continuous compression to 2.7 GPa this cubic polymorph converts into a putative orthorhombic structure. Beyond 4.7 GPa it separates into crystalline and amorphous fractions. During decompression, this phase‐mixed material undergoes distinct restoration pathways depending on the peak pressure. In situ pressure photoluminescence investigation suggests a reduction in band gap with increasing pressure up to ≈0.3 GPa and then an increase in band gap up to a pressure of 2.7 GPa, in excellent agreement with our DFT calculation prediction.
An In Situ One‐Pot Synthetic Approach towards Multivariate Zirconium MOFs
Authors: Sun Yujia , Sun Lixian , Feng Dawei , Zhou Hong‐Cai
Published: April 2016

Chemically highly stable MOFs incorporating multiple functionalities are of great interest for applications under harsh environments. Herein, we presented a facile one‐pot synthetic strategy to incorporate multiple functionalities into stable Zr‐MOFs from mixed ligands of different geometry and connectivity. Via our strategy, tetratopic tetrakis(4‐carboxyphenyl)porphyrin (TCPP) ligands were successfully integrated into UiO‐66 while maintaining the crystal structure, morphology, and ultrahigh chemical stability of UiO‐66. The amount of incorporated TCPP is controllable. Through various combinations of BDC derivatives and TCPP, 49 MOFs with multiple functionalities were obtained. Among them, MOFs modified with FeTCPPCl were demonstrated to be catalytically active for the oxidation of ABTS. We anticipate our strategy to provide a facile route to introduce multiple functionalities into stable Zr‐MOFs for a wide variety of potential applications.
Weak and Transient Protein Interactions Determined by Solid‐State NMR
Authors: Dannatt Hugh R. W. , Felletti Michele , Jehle Stefan , Wang Yao , Emsley Lyndon , Dixon Nicholas E. , Lesage Anne , Pintacuda Guido
Published: April 2016

Despite their roles in controlling many cellular processes, weak and transient interactions between large structured macromolecules and disordered protein segments cannot currently be characterized at atomic resolution by X‐ray crystallography or solution NMR. Solid‐state NMR does not suffer from the molecular size limitations affecting solution NMR, and it can be applied to molecules in different aggregation states, including non‐crystalline precipitates and sediments. A solid‐state NMR approach based on high magnetic fields, fast magic‐angle sample spinning, and deuteration provides chemical‐shift and relaxation mapping that enabled the characterization of the structure and dynamics of the transient association between two regions in an 80 kDa protein assembly. This led to direct verification of a mechanism of regulation of E. coli DNA metabolism.
3D Assembly of All‐Inorganic Colloidal Nanocrystals into Gels and Aerogels
Authors: Sayevich Vladimir , Cai Bin , Benad Albrecht , Haubold Danny , Sonntag Luisa , Gaponik Nikolai , Lesnyak Vladimir , Eychmüller Alexander
Published: April 2016

We report an efficient approach to assemble a variety of electrostatically stabilized all‐inorganic semiconductor nanocrystals (NCs) by their linking with appropriate ions into multibranched gel networks. These all‐inorganic non‐ordered 3D assemblies benefit from strong interparticle coupling, which facilitates charge transport between the NCs with diverse morphologies, compositions, sizes, and functional capping ligands. Moreover, the resulting dry gels (aerogels) are highly porous monolithic structures, which preserve the quantum confinement of their building blocks. The inorganic semiconductor aerogel made of 4.5 nm CdSe colloidal NCs capped with I− ions and bridged with Cd2+ ions had a large surface area of 146 m2 g−1.
Intra‐ and Intermolecular Nickel‐Catalyzed Reductive Cross‐Electrophile Coupling Reactions of Benzylic Esters with Aryl Halides
Authors: Konev Mikhail O. , Hanna Luke E. , Jarvo Elizabeth R.
Published: April 2016

Nickel‐catalyzed cross‐electrophile coupling reactions of benzylic esters and aryl halides have been developed. Both inter‐ and intramolecular variants proceed under mild reaction conditions. A range of heterocycles and functional groups are tolerated under the reaction conditions. Additionally, the first example of a stereospecific cross‐electrophile coupling of a secondary benzylic ester is described.
Selective Hydrogen Generation from Formic Acid with Well‐Defined Complexes of Ruthenium and Phosphorus–Nitrogen PN3‐Pincer Ligand
Authors: Pan Yupeng , Pan Cheng‐Ling , Zhang Yufan , Li Huaifeng , Min Shixiong , Guo Xunmun , Zheng Bin , Chen Hailong , Anders Addison , Lai Zhiping , Zheng Junrong , Huang Kuo‐Wei
Published: April 2016

An unsymmetrically protonated PN3‐pincer complex in which ruthenium is coordinated by one nitrogen and two phosphorus atoms was employed for the selective generation of hydrogen from formic acid. Mechanistic studies suggest that the imine arm participates in the formic acid activation/deprotonation step. A long life time of 150 h with a turnover number over 1 million was achieved.
Variable activation in striatal subregions across components of a social influence task in young adult cannabis users
Authors: Gilman Jodi M. , Lee Sang , Kuster John K. , Lee Myung Joo , Kim Byoung Woo , van der Kouwe Andre , Blood Anne J. , Breiter Hans C.
Published: April 2016

Introduction

Decades of research have demonstrated the importance of social influence in initiation and maintenance of drug use, but little is known about neural mechanisms underlying social influence in young adults who use recreational drugs.

Methods

To better understand whether the neural and/or behavioral response to social influence differs in young adults using illicit drugs, 20 marijuana‐using young adults (MJ) aged 18–25, and 20 controls (CON) performed a decision‐making task in the context of social influence, while they underwent functional magnetic resonance imaging scans. A priori analyses focused on the nucleus accumbens (NAc), with post hoc analyses in the rest of the striatum. In this task, participants could choose to either follow or go against group influence.

Results

When subjects applied social information to response choice selection (independent of following or going against group influence), we observed activation in the middle striatum (caudate), in the MJ group only, that extended ventrally into the NAc. MJ users but not CON showed greater activation in the NAc but not the caudate while making choices congruent with group influence as opposed to choices going against group influence. Activation in the NAc when following social influence was associated with amount of drug use reported. In contrast, during the feedback phase of the task we observed significant NAc activation in both MJ and CON, along with dorsal caudate activation only in MJ participants. This NAc activation did not correlate with drug use.

Conclusions

This study shows that MJ users, but not CON, show differential brain activation across striatal subregions when applying social information to make a decision, following versus going against a group of peers, or receiving positive feedback. The current work suggests that differential neural sensitivity to social influence in regions such as the striatum may contribute to the development and/or maintenance of marijuana use.
Genome‐wide time‐to‐event analysis on smoking progression stages in a family‐based study
Authors: He Liang , Pitkäniemi Janne , Heikkilä Kauko , Chou Yi‐Ling , Madden Pamela A.F. , Korhonen Tellervo , Sarin Antti‐Pekka , Ripatti Samuli , Kaprio Jaakko , Loukola Anu
Published: April 2016

Background

Various pivotal stages in smoking behavior can be identified, including initiation, conversion from experimenting to established use, development of tolerance, and cessation. Previous studies have shown high heritability for age of smoking initiation and cessation; however, time‐to‐event genome‐wide association studies aiming to identify underpinning genes that accelerate or delay these transitions are missing to date.

Methods

We investigated which single nucleotide polymorphisms (SNPs) across the whole genome contribute to the hazard ratio of transition between different stages of smoking behavior by performing time‐to‐event analyses within a large Finnish twin family cohort (N = 1962), and further conducted mediation analyses of plausible intermediate traits for significantSNPs.

Results

Genome‐wide significant signals were detected for three of the four transitions: (1) for smoking cessation on 10p14 (P = 4.47e‐08 for rs72779075 flanked byRP11‐575N15andGATA3), (2) for tolerance on 11p13 (P = 1.29e‐08 for rs11031684 inRP1‐65P5.1), mediated by smoking quantity, and on 9q34.12 (P = 3.81e‐08 for rs2304808 inFUBP3), independent of smoking quantity, and (3) for smoking initiation on 19q13.33 (P = 3.37e‐08 for rs73050610 flanked byTRPM4andSLC6A16) in analysis adjusted for first time sensations. Although our topSNPs did not replicate, anotherSNPin theTRPM4‐SLC6A16gene region showed statistically significant association after region‐based multiple testing correction in an independent Australian twin family sample.

Conclusion

Our results suggest that the functional effect of theTRPM4‐SLC6A16gene region deserves further investigation, and that complex neurotransmitter networks including dopamine and glutamate may play a critical role in smoking initiation. Moreover, comparison of these results implies that genetic contributions to the complex smoking behavioral phenotypes vary among the transitions.
Exercise therapy improves aerobic capacity of inpatients with major depressive disorder
Authors: Kerling Arno , von Bohlen Anne , Kück Momme , Tegtbur Uwe , Grams Lena , Haufe Sven , Gützlaff Elke , Kahl Kai G.
Published: April 2016

Background

Unipolar depression is one of the most common diseases worldwide and is associated with a higher cardiovascular risk partly due to reduced aerobic capacity.

Objectives

Therefore, the aim of our study was to examine whether a structured aerobic training program can improve aerobic capacity in inpatients with MDD (major depressive disorder).

Methods

Overall, 25 patients (13 women, 12 men) diagnosed with MDD were included in the study. Parameters of aerobic capacity, such as maximum performance, maximum oxygen consumption, and VAT (ventilatory anaerobic threshold), were assessed on a bicycle ergometer before and 6 weeks after a training period (three times per week for 45 min on two endurance machines). In addition, a constant load test was carried out at 50% of the maximum performance prior to and after the training period. The performance data were compared with 25 healthy controls matched for sex, age, and body mass index before and after the training period.

Results

Compared to controls, patients with MDD had significantly lower aerobic capacity. After training, there was a significant improvement in their performance data. A significant difference remained only for VAT between patients with MDD and healthy controls.

Conclusion

With regard to the coincidence of MDD with cardiovascular and cardiometabolic disorders, a structured supervised exercise program carried out during hospitalization is a useful supplement for patients with MDD.
Development of educational software for undergraduate Chemical Engineering courses
Authors: Dabaghian Zoheir , Movagharnejad Kamyar , Mohammadi Maedeh
Published: April 2016

An instructive software was developed and programmed as an educational aid for design of distillation tower and tray hydraulics using visual basic language. This user‐friendly software can be used as an educational aid for undergraduate Chemical Engineering courses. This tool allows students to study the behavior of the distillation tower and explore the different mass transfer and unit operation features. The students will be able to perform many simulation exercises including the tower overall and interior design and predict the behavior of undesired phenomena such as weeping and flooding. The software environment facilitates students’ learning by providing a step‐by‐step procedure and instructions that are consistent with standard course books. © 2016 Wiley Periodicals, Inc. Comput Appl Eng Educ 24:577–585, 2016; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.21733
Phase II evaluation of sunitinib in the treatment of recurrent or refractory high‐grade glioma or ependymoma in children: a children's Oncology Group Study ACNS1021
Authors: Wetmore Cynthia , Daryani Vinay M. , Billups Catherine A. , Boyett James M. , Leary Sarah , Tanos Rachel , Goldsmith Kelly C. , Stewart Clinton F. , Blaney Susan M. , Gajjar Amar
Published: April 2016

Sunitinib malate is a small multi‐targeted tyrosine kinase inhibitor that inhibits vascular endothelial growth factor receptor (VEGFR), platelet‐derived growth factor receptor (PDGFR) and stem cell factor receptor (KIT), which are highly expressed by some high‐grade brain tumors. We conducted a phase II study to estimate the efficacy and further characterize the pharmacokinetics of sunitinib in pediatric patients with recurrent or refractory high‐grade glioma (Stratum A) or ependymoma (Stratum B). This was a prospective, multicenter Phase II trial conducted through the Children's Oncology Group (ClinicalTrials.gov Identifier NCT01462695). Sunitinib, 15 mg/m2, was orally administered once daily for 4 weeks every 6 weeks. The safety and tolerability of sunitinib, an estimate of progression‐free survival (PFS), analyses of sunitinib pharmacokinetics (PK) and pharmacodynamics modulation of plasma VEGF and VEGFR2 were also assessed. Thirty eligible patients (17 patients on Stratum A, 13 patients on Stratum B) were enrolled and 29 patients were evaluable for response. Sunitinib was reasonably well tolerated in children with recurrent ependymoma or high‐grade glioma. Most adverse events were of mild‐to‐moderate severity and manageable with supportive treatment. While there was a statistically significant modulation of plasma VEGFR2 with sunitinib exposure, there were no sustained tumor responses. Both strata were closed at time of planned interim analysis as there was not sufficient efficacy associated with sunitinib in children with recurrent brain tumors. Sunitinib was well tolerated in children and young adults with recurrent high‐grade glioma or ependymoma but had no single agent objective antitumor activity in these patients.
Capecitabine‐related liver lesions: sinusoidal dilatation mimicking liver metastasis
Authors: Groom Katherine , Penna Marta , Arul Dhili , Steward Michael , Leonard Pauline , Wilson Jonathan
Published: April 2016

Key Clinical Message

A 30‐year‐old lady treated with capecitabine for primary colon adenocarcinoma developed liver lesions suspicious for metastasis. Liver biopsies showed sinusoidal dilatation thought to be secondary to capecitabine. This case highlights the importance of differentiating between benign and malignant liver lesions during cancer surveillance preventing unnecessary liver resections for benign disease.
ChemInform Abstract: SYNTHESIS OF PENTA‐N,O‐ACETYL‐DL‐VALIENAMINE AND ITS RELATED BRANCHED‐CHAIN UNSATURATED AMINOCYCLITOLS AND CYCLITOLS
Authors: OGAWA S. , TOYOKUNI T. , SUAMI T.
Published: April 2016

Das Cyclohexentriol‐trisacetat (I) wird bromiert, die dabei gebildeten isomeren Dibromide (II) werden getrennt und daraus die Derivate (III) hergestellt.
ChemInform Abstract: CARBONATES AND POLYCARBONATES FROM UREA AND ALCOHOL
Authors: BALL P. , FUELLMANN H. + , HEITZ W.
Published: April 2016

Harnstoff reagiert mit primären und sekundären Alkoholen katalytisch in einer zweistufig verlaufenden Reaktion zu Carbonsäureestern und Ammoniak, das wieder in den Kreisprozeß eingeht.
ChemInform Abstract: FACILE SYNTHESES OF 1,3‐DITHIOL‐2‐ONES AND 1,3‐DITHIOL‐2‐THIONES
Authors: HALEY N. F. , FICHTNER M. W.
Published: April 2016

Aus den Olefinen (I) entstehen die Allylhalogenide (II), die zu den Thiocarbonaten (III) substituiert werden.
ChemInform Abstract: SIMPLE SYNTHESIS OF 4‐(HETEROARYLMETHYL)PHENOLS AND THEIR ACYLATION
Authors: KUEBEL B. +
Published: April 2016

Der Benzaldehyd (I) wird mit Acetessigester (IIa) oder Acetylaceton (IIb) zu den Produkten (III) kondensiert, die zu den Verbindungen (IV) hydriert werden.
ChemInform Abstract: SYNTHESIS OF 1,1′‐DIMERCAPTODIMETHYL SELENIDE AND 1,1′‐BIS(HYDROSELENO)DIMETHYL SELENIDE FROM 1,1′‐DIBROMODIMETHYL SELENIDE
Authors: SCHMIDT M. , HOFFMANN G. G.
Published: April 2016

Die Titelselenide (III) werden aus Bis‐ [brommethyl]‐selenid (I) über die mit Na‐disulfid bzw. Na‐diselenid erhaltenen Poly(dithiomethyl)‐ und Poly(diselenomethyl)selenide (II) und deren Spaltung mit Na in flüssigem Ammoniak bei anschließender Hydrolyse dargestellt.
ChemInform Abstract: THE REACTION OF MOLYBDENUM(VI) DIOXO DERIVATIVES WITH HETEROCUMULENES
Authors: CENINI S. , PIZZOTTI M.
Published: April 2016

Die Reaktionen der Mo(VI)‐Chelatkomplexe (I) mit (II) liefern die Oxoary1irnido‐ Derivate (III) und S02.
ChemInform Abstract: CHARACTERIZATION OF TWO SYNAPTOSOMAL PEPTIDES IN CALF BRAIN
Authors: LAEHDESMAEKI P. + , AIRAKSINEN K. , VARTIAINEN M. , HALONEN P.
Published: April 2016

Die beiden Peptide wurden chromatographisch und durch Gelfiltration gereinigt und mittels der Dansyl‐ Chlorid‐Methode und Spaltung durch Peptidasen als H‐Ala‐Gly‐Glu‐phosphoserin‐ OH und N‐Acetyl‐Asp‐Glu‐taurin‐OH charakterisiert.
ChemInform Abstract: SYNTHETIC OPIUM ALKALOIDS AND DERIVATIVES. A SHORT TOTAL SYNTHESIS OF (.+‐.)‐DIHYDROTHEBAINONE, (.+‐.)‐DIHYDROCODEINONE, AND (.+‐.)‐NORDIHYDROCODEINONE AS AN APPROACH TO A PRACTICAL SYNTHESIS OF MORPHINE, CODEINE, AND CONGENERS
Authors: RICE K. C.
Published: April 2016

Aus Phenethylamin (I) und der Phenylessigsäure (II) ist über die im Formelschema angegebenen Stufen das Bromierungsprodukt (VIa) erhältlich, das zum Derivat (VIb) ‐verseift und zu (VII) umgelagert werden kann.
ChemInform Abstract: OXIDATION STATE, VALENCY, AND ELECTRON CONFIGURATION OF TIN IN A LINEAR SULFUR‐TIN‐SULFUR ARRAY
Authors: HERBER R. H. , DISALVO F. J. , FRANKEL R. B.
Published: April 2016

Messungen des 119Sn‐Mößbauer‐Effekts an der Einschlußverbindung TaS2·Sn bei 4.2 K und äußeren magnetischen Feldstärken von 0,50 und 80 kOe bestätigen frühere Beobachtungen (magnetische und ESCA‐Daten), daß keine signifikante Dichte ungepaarter Elektronen am Metallatom lokalisiert ist.
ChemInform Abstract: CRYSTAL AND MOLECULAR STRUCTURE OF MOLYBDENUM TETRACHLORIDE OXIDE BY NEUTRON AND X‐RAY DIFFRACTION
Authors: TAYLOR J. C. , WAUGH A. B.
Published: April 2016

MoOCl4 kristallisiert in der Raumgruppe Pl mit Z=2.
ChemInform Abstract: PHOTOELECTROCHEMICAL COMPATIBILITY OF N‐TUNGSTEN SELENIDE AND N‐MOLYBDENUM SELENIDE WITH VARIOUS REDOX SYSTEMS
Authors: MENEZES S. , DISALVO F. J. , MILLER B.
Published: April 2016

Untersuchungen mit Hilfe hydrodynamisch modulierter rotierender Scheiben‐ und Ring‐Scheiben‐Elektroden gestatten die Auftrennung der photoelektrochemischen Reaktionen an n‐WSeZ und n‐MoSe2 in verschiedenen Redox‐Elektrolyten in Komponenten für Löchertransfer und Photokorrosion.
ChemInform Abstract: RAMAN SPECTROSCOPIC STUDIES OF AQUEOUS URANYL NITRATE AND PERCHLORATE SYSTEMS
Authors: BROOKER M. H. , HUANG C.‐H. , SYLWESTROWICZ J.
Published: April 2016

Raman‐Spektren der Schmelzen der hydratisierten Salze (I) und (II) sowie ihrer wäßrigen Lösungen zeigen, daß (I) in wäßriger Lösung oberhalb 1.5 Mden schwachen Komplex UOZNO; bildet (B1 = 0.15 bei einer Ionenstärke von 6.25), während beim Perchlorat (II) keine Ionenpaarbildung auftritt.
ChemInform Abstract: PREPARATION AND RAMAN SPECTRA OF CALCIUM AND MAGNESIUM NITRITE MONOHYDRATES AND CALCIUM NITRITE
Authors: BROOKER M. H. , DEYOUNG B. S.
Published: April 2016

H2O, Ca(NO2)2 and Mg(NO2)2°C H2O. ‐ Die Titelsalze werden aus wäßriger Lösung nach Reaktion A und Bdargestellt und Raman‐spektroskopisch bei 77 Kcharakterisiert.
ChemInform Abstract: BORON ANALOGS OF THE α‐AMINO ACIDS. SYNTHESIS, X‐RAY CRYSTAL STRUCTURE, AND BIOLOGICAL ACTIVITY OF AMMONIA‐CARBOXYBORANE, THE BORON ANALOG OF GLYCINE
Authors: SPIELVOGEL B. F. , DAS M. K. , MCPHAIL A. T. , ONAN K. D. , HALL I. H.
Published: April 2016

Durch Aminaustausch in der entsprechenden Trimethylaminverbindung mit fl.
ChemInform Abstract: STRUCTURAL INVESTIGATION OF A B‐FERROCENYL‐SUBSTITUTED TETRACARBON CARBORANE, 4((η5‐C5H5)FE(η5‐C5H4))‐2,3,7,8‐(CH3)4C4B8H7
Authors: GRIMES R. N. , MAXWELL W. M. , MAYNARD R. B. , SINN E.
Published: April 2016

Die Reaktion von (CH3)4C4B SHS mit Na‐naphthalenid, FeClg und NaCSHS in THF liefert die Titelverbindung (Ausb.‐ Angabe in mg), die durch "B‐, 1H‐NMR‐ und Massenspektren sowie eine Einkristallröntgendiffraktionsuntersuchung charakterisiert wird.
ChemInform Abstract: LOW‐TEMPERATURE CRYSTAL AND MOLECULAR STRUCTURE OF THE μ‐BROMO‐HEXACARBONYL(OCTAHYDROTRIBORATO(1‐))DIMANGANESE, (μ‐BR)(CO)6(B3H8)MN2
Authors: CHEN M. W. , GAINES D. F. , HOARD L. G.
Published: April 2016

Die Synthese der Titelverbindung (II) erfolgt wie aufgezeigt aus (I) mit 35% Ausb. und aus (III) und (IV) mit 15% Ausbeute.
ChemInform Abstract: DIVALENT LANTHANIDE CHEMISTRY. BIS (PENTAMETHYLCYCLOPENTADIENYL) EUROPIUM(II) AND ‐YTTERBIUM(II) DERIVATIVES: CRYSTAL STRUCTURE OF BIS (PENTAMETHYLCYCLOPENTADIENYL) (TETRAHYDROFURAN YTTERBIUM(II) ‐HEMITOLUENE AT 176 K
Authors: TILLEY T. D. , ANDERSEN R. A. , SPENCER B. , RUBEN H. , ZALKIN A. , TEMPLETON D. H.
Published: April 2016

Die Reaktion von 3 Mol‐ äquivalenten Na‐pentamethylcyclopentadienid mit EuCl3 in siedendem THF liefert nach Umkristallisieren aus Diethylether den roten, paramagnetisohen Komplex (II).
ChemInform Abstract: A ONE POT REACTION INVOLVING HYDROLYSIS‐REDUCTION OF BIPHTHALYLIDENE IN AN ALKALINE MEDIUM
Authors: TASHIRO M. , SUMIDA T. , FUKATA G.
Published: April 2016

Das durch Kupplung von Phthalsäureanhydrid (I) mit Triethylphosphit (II) erhaltene Biphthalyliden (III) wird unter Baseneinwirkung zu einem Gemisch aus dem Dicarboxybenzoin (IV), dem ringgeschlossenen isomeren Lacton (V), Phtha‐ lid (VI) und Phthalsäure (VII) gespalten.
ChemInform Abstract: ELECTRON DEFICIENT HETEROAROMATIC AMMONIOAMIDATES. PART 19. N‐(3‐QUINAZOLINIO)AMIDATES. PART 7. PHOTOCHEMISTRY OF N‐(3‐QUINAZOLINIO)AMIDATES IN THE PRESENCE OF AMINES AND OF ACETAMIDE
Authors: BARTA‐SZALAI G. , FETTER J. , LEMPERT K. , MOELLER J.
Published: April 2016

Bestrahlung (durch Pyrex‐Filter) der Chinazolinio‐ amidate (II) und der Dimeren (III) in Butylamin (Ia), von (IIIb) zusätzlich in Benzylamin (Ib), Morpholin (Ic) bzw. in Gegenwart von Acetamid (Id) in Dioxan (Ie) oder 70 CH2Cl2 sowie der Addukte (IV) in CH2Cl2 führt zu komplexen Gemischen aus Verbindungen vom Typ (V)‐(X).
ChemInform Abstract: PHOTOCHEMISTRY OF IMINIUM SALTS IN THE PRESENCE OF N‐ELECTRON DONATING ALCOHOLS AND ETHERS
Authors: STAVINOHA J. , BAY E. , LEONE A. , MARIANO P. S.
Published: April 2016

Bei der Photolyse der 2‐Phenyl‐1‐pyrrolinium‐Salze (I) in Tetrahydrofuran (II) bzw. Methanol entstehen Addukte (III) bzw. (IV) bzw. aus (Ia) und Methanol das Cyclisierungsprodukt (V) durch gleichzeitig gebildeten Formaldehyd.
ChemInform Abstract: CHEMICAL PROPERTIES OF THE FULVENE RADICAL CATION: A CYCLOADDITION WITH 1,3‐BUTADIENE
Authors: RUSSELL D. H. , GROSS M. L.
Published: April 2016

Mittels Cyclotron‐Resonanz‐Spektroskopie wurden die Ion‐Molekül‐Reaktionen des Ions mit Benzol, Prl, Alkenen, MeOCH=CH2 oder 1,3‐Butadien untersucht.
ChemInform Abstract: AN ACID‐PROOF BASIC CATALYST FOR THE SELECTIVE DEHYDROCHLORINATION OF 1,1,2‐TRICHLOROETHANE
Authors: MOCHIDA I. , WATANABE H. , FUJITSU H. , TAKESHITA K.
Published: April 2016

Das Trichlorethan (I) wird in Gegenwart von Methylimidazol/ HCl/SiO2 bei 250°C zum Dichlorethylen (II) dehydrochloriert.
ChemInform Abstract: RHODIUM TRICHLORIDE‐CATALYZED AMIDE BOND FORMATION UNDER MILD CONDITIONS
Authors: YAMAMOTO Y. , YATAGAI H. , MARUYAMA K.
Published: April 2016

Durch Rhodiumtrichlorid wird die Reaktion der Ester (I) mit n‐Butylamin zum Carbonsäureamid (III) beschleunigt.
ChemInform Abstract: A SHORT NEW AZULENE SYNTHESIS
Authors: SCOTT L. T. , MINTON M. A. , KIRMS M. A.
Published: April 2016

Aus den Säurechloriden (I) werden die Diazoketone (II) hergestellt, die zu den Azulenonen (III) cyclisiert werden.
ChemInform Abstract: A SIMPLE METHOD FOR PREPARATION OF ARYL 2,2,2‐TRIFLUOROETHYL ETHERS
Authors: CAMPS F. , COLL J. , MESSEGUER A. , PERICAS M. A.
Published: April 2016

Natriumphenolate, z.B. (I), werden mit 2,2,2‐Trifluorethyl‐methansulfonat (II) in Hexamethylphosphorsäuretriamid (HMPT) zu Trifluorethyl‐phenylethern (III) umgesetzt.
ChemInform Abstract: ACTIVE ESTERS OF ANTHRANILIC ACID; N‐(O‐AMINOBENZOYLOXY)IMIDES AS REAGENTS FOR O‐AMINOBENZOYLATION
Authors: HINMAN C. , VAUGHAN K.
Published: April 2016

Anthranilsäure (I) wird mit N‐Hydroxysuccinimid (II) in Gegenwart von Dicyclohexylcarbodiimid in den aktiven Ester (III) übergeführt, der mit aliphatischen Aminen (IV) Anthranilamide (V) in guten Ausbeuten liefert.
ChemInform Abstract: TRAPPING THE INTERMEDIATE INVOLVED IN THE INTRAMOLECULAR CYCLIZATION OF CYCLOPROPYL KETONES. A CONVENIENT PREPARATION OF OPEN‐CHAIN Γ‐HYDROXY KETONES
Authors: MURPHY W. S. , WATTANASIN S.
Published: April 2016

Bei der Behandlung mit Zinntetrachlorid erhält man aus den Phenylcyclopropyl‐phenylketonen (I) die 1‐Tetralone (II) und die Carbinole (III) in Form der beiden Stereoisomeren.
ChemInform Abstract: NITROGEN‐CONTAINING CARCINOGENIC COMPOUNDS. LXXXVII. SYNTHESIS OF FLUORINATED D AND TRIFLUOROMETHYLATED INDOLO(2,3‐A)CARBAZOLES AND INDOLO(2,3‐A)ACRIDINES
Authors: STRAPPAGHETTI A. , RABERE G. , FRAVOLINI A. , JACQUIGNON P.
Published: April 2016

Durch Umsetzung von 2‐Hydroxymethylencyclohexanon (I) mit Diazoniumsalzen von Fluor‐ und Trifluormethyl‐anilinen (II) und anschließende Fischer‐Cyclisierung der gebildeten Phenylhydrazone werden die fluor‐ und trifluormethylsubstituierten l‐Keto‐tetrahydrocarbazole (III) synthetisiert.
ChemInform Abstract: SYNTHETIC STUDIES OF THE FLAVONE DERIVATIVES. VII. SYNTHESIS OF 6,8‐DIMETHOXYFLAVONE DERIVATIVES AND THEIR 13C‐NMR
Authors: IINUMA M. , MATSUURA S.
Published: April 2016

Die beiden Flavone (I) und (III) werden ausgehend von dem Benzaldehyd (II) in einer mehrstufigen Synthese hergestellt.
ChemInform Abstract: THE USE OF DIETHYL 3‐OXOHEPTANEDIOATE IN THE PECHMANN CYCLOCONDENSATION
Authors: CHATTERJEE A. , MALLIK R.
Published: April 2016

Die sauer katalysierte Kondensation von Resorcin‐monomethylether (I) mit 3‐Oxoheptandicarbonsäureester (II) führt zum Cumarin‐4‐butancarbonsäureester (III), der nach Verseifung mit Polyphosphorsäure zum tricyclischen Oxolacton (IV) cyclisiert wird.
ChemInform Abstract: PREPARATION OF 1,4‐DIPHENYL‐3‐SUBSTITUTED ISOQUINOLINES
Authors: MATAKA S. , TAKAHASHI K. , TSUDA Y. , TASHIRO M.
Published: April 2016

0‐Dibenzoylbenzol (I) reagiert mit den Aminen (II) in Gegenwart von Basen wie 1,5‐Diazabicyclo(5,4,0)‐ undec‐5‐en (DBU), Kaliumhydroxid oder Kalium‐tert.‐butylat in Alkoholen oder Toluol zu den Isochinolinen (III) und (IV).
ChemInform Abstract: STUDIES ON HETEROCYCLIC CHEMISTRY. 23. FORMATION OF 1,1′‐BI‐1H‐PYRROLO(3,2‐C)PYRIDINES BY THE DEOXYGENATION OF 4‐NITRO‐3‐STYRYLPYRIDINE 1‐OXIDES WITH TERVALENT PHOSPHORUS COMPOUNDS
Authors: NISHIWAKI T. , ABE N. , MORIYASU K.
Published: April 2016

Die Desoxygenierung der Pyridin‐N‐oxide (I) ergibt die Bi‐pyrrolo‐pyridine (II).
ChemInform Abstract: SYNTHESIS OF PROXL‐BENZOISOALLOPURINOL
Authors: FOSTER R. H. , LEONARD N. J.
Published: April 2016

Aus der Methylanthranilsäure (I) entsteht mit Formamid das Chinazolinon (IIa), dessen Derivat (IIc) mit Nitrit das prox‐Benzoisoallopurinol (III) liefert.
ChemInform Abstract: ANTIINFLAMMATORY AND ANALGESIC PROFILE OF AMIDINES OF 3‐AMINO‐1,2,4‐BENZOTRIAZINE AND 3‐AMINO‐1,2,4‐BENZOTRIAZINE‐1‐OXIDE
Authors: REGAN B. A. , HANIFIN J. W. , LANDES M. J. , OSTERBERG A. C. , PATEL G. J. , RIDGE D. N. , SLOBODA A. E. , LANG S. A. JUN.
Published: April 2016

Die Reaktion der Benzotriazinamine (I) bzw. ihrer 1‐N‐Oxide mit den Amidacetalen (II) ergibt in guter Ausbeute die Amidine (III).
ChemInform Abstract: BRIDGED‐RING NITROGEN COMPOUNDS. PART 4. SYNTHESIS AND APPLICATIONS OF 8‐ETHOXYCARBONYL‐6,7‐DIHYDRO‐2‐METHOXYBENZOCYCLOHEPTEN‐5‐ONE; PREPARATION OF METHANOBENZAZOCINES AND ETHANOBENZAZEPINES
Authors: PROCTOR G. R. , SMITH F. J.
Published: April 2016

Ausgehend von dem Methoxybenzaldehyd (I) und dem Diester (II) wird nach angegebener Reaktionsfolge das Benzosuberon (IVb) dargestellt, aus dem über den Alkohol (Va) das Keton (Vc) zugänglich ist.
ChemInform Abstract: BORON‐NITROGEN COMPOUNDS. 85. STUDIES ON (ALKYLTHIO)(DIMETHYLAMINO)BORANE AND D (ETHYLTHIO)PHENYLBORANE SYSTEMS
Authors: NIEDENZU K. , READ R. B. , SEELIG S. S.
Published: April 2016

(V), die miteinander im Gleichgewicht vorliegen.
ChemInform Abstract: SYNTHESIS AND REACTIONS OF POLYMER‐ANCHORED MOLYBDENUM(V AND VI) TRIPEPTIDE COMPLEXES
Authors: TOPICH J.
Published: April 2016

Als potentielle Modelle für Molybdoenzyme werden einfache Peptide als Koordinationsliganden gewählt, wobei diese an eine unlösliche Polystyrolmatrix gebunden sind.
ChemInform Abstract: REACTIVITY OF THE REOX3(PPH3)2 COMPLEXES (X = CL OR BR) WITH SCHIFF BASES
Authors: MAZZI U. , RONCARI E. , ROSSI R. , BERTOLASI V. , TRAVERSO O. , MAGON L.
Published: April 2016

Die Re‐Komplexe (I), (III) und (IV) werden durch Umsetzung der Oxotrihalogeno‐ Re(V)‐Komplexe (II) mit den entsprechenden Schiffschen Basen, ihren Trimethylsilyl‐ oder Li‐Derivaten wie aufgezeichnet synthetisiert.
ChemInform Abstract: ((R)‐2‐METHYL‐1,4,7‐TRIAZACYCLONONANE)(1,1,1‐TRIS(AMINOMETHYL)ETHANE)COBALT(III) AND SOME MONO((R)‐2‐METHYL‐1,4,7‐TRIAZACYCLONONANE)COBALT(III) COMPLEXES
Authors: NONOYAMA M.
Published: April 2016

Der Co(III)‐Titelkomplex (Ia) wird durch die 1:1:1‐molare Umsetzung von Co(II)‐ chloridhexahydrat und den Trihydrochloriden der beiden N3‐Liganden in Gegenwart von LiOH unter Luftoxidation als säulenchromatographisch trennbares Gemisch zweier Isomeren synthetisiert.
ChemInform Abstract: PURINE COMPLEXES WITH DIVALENT 3D METAL CHLORIDES
Authors: SPECA A. N. , MIKULSKI C. M. , IACONIANNI F. J. , PYTLEWSKI L. L. , KARAYANNIS N. M.
Published: April 2016

Die 2:1‐molare Umsetzung von Purin mit den entsprechenden Metall(II)‐chloriden in Ethanol/Triethylorthoformiat führt zu den 1:1‐Komplexen (I) mit linearer oligomerer Struktur, in der das über sein N(3)‐ und sein N(9)‐Atom gebundene Purin als Brücke fungiert und nur terminale Chloridliganden vorliegen.
ChemInform Abstract: DECARBOXYLATION SYNTHESES OF TRANSITION METAL ORGANOMETALLICS. II. TRANS‐CARBONYL(POLYHALOGENOPHENYL)BIS(TRIPHENYLPHOSPHINE)RHODIUM(I) COMPOUNDS
Authors: DEACON G. B. , FAULKS S. J. , MILLER J. M.
Published: April 2016

Die Rh(I)‐carboxylate (III) werden durch die Reaktion a) des Hydrido‐Komplexes (I) mit den entsprechenden Carbonsäuren (II) und/oder b) von trans‐Chlorocarbonylbis‐[triphenylphosphin]‐Rh mit den aus den Säuren (II) und Tl‐carbonat synthetisierten Tl‐carboxylaten (Ausb. 48‐99%) dargestellt.
ChemInform Abstract: BI‐ AND POLYNUCLEAR ORGANOMETALLIC COMPLEXES OF PALLADIUM(II) WITH 4,4′‐BIPYRIDINE
Authors: USON R. , FORNIES J. , NAVARRO R. , GALLO A.
Published: April 2016

Die zweikernigen 4,4′‐bipyridyl‐verbrückten Pd‐Komplexe (II) und (IV) werden durch Umsetzung der Pd‐Ausgangskomplexe (I) bzw. (III) mit Bipyridyl erhalten.
ChemInform Abstract: TOTAL SYNTHESIS OF (.+‐.)‐HIRSUTENE
Authors: HUDLICKY T. , KUTCHAN T. M. , WILSON S. R. , MAO D. T.
Published: April 2016

Eine neue Synthese der Titelverbindung (XI) wirdbeschrieben.
ChemInform Abstract: FLUORINATED STEROIDS. II. POLYHALOGEN DERIVATIVES
Authors: NEDER A. , USKERT A. , MEHESFALVI ZS. , KUSZMANN J.
Published: April 2016

Umsetzung der 5,6‐ungesättigten Steroide (I), (IV) bzw. (VI) mit BrF ‐ erzeugt aus HF und NBS bzw. aus HF/Pyridin und NBS ‐ verläuft überwiegend unter Bildung der Soz‐Brom‐öß‐fluor‐Derivate (IIa), (III) bzw. (VIIa); aus (I) bzw. (VI) entstehen auch die Produkte (IIb)‐(IId) bzw. (VIIb).
ChemInform Abstract: STEROIDS. PART CCXXXV. ANALOGS OF ANDROGENS WITH THE OPEN RING A
Authors: KASAL A.
Published: April 2016

Die Synthese des A‐nor‐3,5‐seco‐Analogen (IV) von 5,6‐Dehydro‐epi‐androsteron beruht auf einem Unterschied in der Acy1ierungs‐ und Oxidationsgeschwindigkeit der beiden Hydroxylgruppen des aus dem nor‐seco‐Testosteron‐pivalat (Ia) über den Ester (Ib), (II) und dessen Desulfurierungsprodukt erhältlichen Diols (III).
ChemInform Abstract: INCORPORATION OF TRANS‐OLEFINIC DIPEPTIDE ISOSTERES INTO ENKEPHALIN AND SUBSTANCE P ANALOGS
Authors: COX M. T. , GORMLEY J. J. , HAYWARD C. F. , PETTER N. N.
Published: April 2016

Dargestellt werden die Verbindungen (II) sowie (IV), (VI) und (VII).
ChemInform Abstract: AN ALTERNATIVE SYNTHESIS OF DIPEPTIDOAMINOBENZOPHENONE AND NOVEL HETEROCYCLIC FORMATIONS OF RING‐OPENED 1,4‐BENZODIAZEPINE DERIVATIVES
Authors: HIRAI K. , ISHIBA T. , FUJISHITA T. , SUGIMOTO H.
Published: April 2016

Das aus dem Aminodichlorbenzophenon (I) darstellbare Glycin‐N‐methylanilid (II) cyclisiert mit Basen spontan zum Benzodiazepinon (III), mit Chloracetylchlorid (IV) wird aus (III) das Peptid (V) erhalten, das sich mit KI zum Iodoacetamid (VI) umsetzen läßt. K‐phthalimid (VII) wird von (VI) zum Phthaloyldipeptid (VIII) alkyliert, das durch Hydrazinolyse in das Diglycylmethylaminobenzophenon (IX) übergeführt wird.
ChemInform Abstract: SYNTHESIS OF METHYL 2,3‐DI‐O‐METHYL‐α‐D‐SIBIROSAMINIDE
Authors: YOSHIMURA J. , HONG N. , RAHMAN A. U. , SATO K.
Published: April 2016

Ausgehend vom Benzylidenaltropyranosid (I) wird der Deoxymethylaminozucker (III) über den Ketozucker (IIa) und das Oxim (IIb) synthetisiert.
ChemInform Abstract: SYNTHESIS OF DINUCLEOSIDE PHOSPHATES CONTAINING 5′‐O‐BONDED 1‐(6‐DEOXY‐β‐D‐ALLOFURANOSYL)URACIL AND 1‐(6‐DEOXY‐α‐L‐TALOFURANOSYL)URACIL
Authors: PADYUKOVA N. SH. , SMRT J.
Published: April 2016

Aus der geschützten β‐D‐Allofuranose (Ia) wird über die Derivate (Ib) und (Ic) das Nucleosid (Id) dargestellt und mit den Ribonucleosidphosphaten (III) zu den geschützten Dinucleosidphosphaten (IV) umgesetzt, deren Hydrolyse zu den freien Dinucleosidphosphaten (V) führt.
ChemInform Abstract: THERMOGRAVIMETRIC ANALYSIS OF COBALT SULFATE
Authors: NANDI P. N. , KHER V. G. , WANKAR G. B. , DESHPANDE D. A.
Published: April 2016

Unabhängig bei Temp. von 12.5, 40 und 50°C gezüchtete Co‐sulfat‐Kristalle (bei 12.5 und 40°C entsteht das Heptahydrat, bei 50°C das Hexahydrat) werden thermogravimetrisch untersucht.
ChemInform Abstract: COMPLEX FORMATION BETWEEN SILVER(+) AND PHOSPHATE(3‐) IN MOLTEN EQUIMOLAR (POTASSIUM, SODIUM) NITRATE. A COMPARISON WITH OTHER SILVER(I) OXOANION COMPLEXES IN THE SAME MEDIUM
Authors: HOLMBERG B. , THOME G.
Published: April 2016

Die Stabilitätskonstanten für die Komplexe AgPOä ′und Agg PO; werden aus potentiometrischen Daten für den Temp.‐Bereich 524‐622 K bestimmt.
ChemInform Abstract: STUDIES OF HYDROLYZED ALUMINUM CHLORIDE SOLUTIONS. 1. NATURE OF ALUMINUM SPECIES AND COMPOSITION OF AQUEOUS SOLUTIONS
Authors: BOTTERO J. Y. , CASES J. M. , FIESSINGER F. , POIRIER J. E.
Published: April 2016

Der Hydrolyse‐Fällungs‐Prozeß von Al(OH)3 aus AlCl3‐Lösung wird bei einer AI‐Konzentration von l0" Mbei 25°C "Al‐NMR‐ spektroskopisch und durch pH‐Titration untersucht.