bluuebunny/crossref_metadata_2025 huggingface dataset:
The effectiveness and harms of bortezomib in combination with chemotherapy for mantle cell lymphoma
Authors: Wang Xiaoxia , Li Wen , Wang Xin , Liu Xiaoli , Feng Cuijuan , Li Yihan , Li Jing
Published: July 2020

Background:

Chemotherapy with or without consolidation followed by autologous hematopoietic stem cell transplantation is the first-line treatment for mantle cell lymphoma. However, the effectiveness and safety of bortezomib-based chemotherapy for patients with mantle cell lymphoma is still uncertain.

Methods:

In this systematic review, the electronic databases of Cochrane Central Register of Controlled Trials, EMBASE, and PUBMED will be searched from inception to May 1, 2020. Randomized controlled trials that assessed the effectiveness and safety of bortezomib in combination with chemotherapy for patients with mantle cell lymphoma will be included. The patient's important outcomes include overall survival, progression-free survival, overall response rate, quality of life, and serious adverse events (eg, grade III-IV peripheral neuropathy, neutropenia, and infection). All process of the study selection, data extraction, and methodology evaluation will be carried out by 2 authors independently. RevMan 5.3 software will be utilized for statistical analysis.

Results:

This study will provide a detailed summary of latest evidence related to the effectiveness and safety of bortezomib in combination with chemotherapy in overall survival, progression-free survival, overall response rate, quality of life, and serious adverse events for patients with mantle cell lymphoma

Conclusion:

The findings of this study may provide possible guidance for bortezomib in combination with chemotherapy for patients with mantle cell lymphoma.

Systematic review registration:

PROSPERO CRD 42020154938.
Rapidly growing Fibro-osseous pseudotumor of the digit
Authors: Sakuda Tomohiko , Kubo Tadahiko , Shinomiya Rikuo , Furuta Taisuke , Adachi Nobuo
Published: July 2020

Introduction:

Fibro-osseous pseudotumor of the digit is a rare benign lesion of subcutaneous tissue that typically arises in the parabone site of the proximal phalanx in young adult females. The lesion is histopathologically characterized by fibroblastic proliferation and osteoid formation. Good prognosis following complete surgical excision of the tumor has been reported, with a very low recurrence rate and no reports of malignant transformation. Despite its benign clinical behavior, the lesion can be mistaken for a malignant neoplasm, such as an extraskeletal or parosteal osteosarcoma, in case of rapid growth, thereby rendering the diagnosis challenging.

Patient concerns:

We report the case of a 30-year-old right-handed male who presented to our hospital with a rapidly growing mass on the dorsal aspect of the right little finger.

Diagnosis:

The patient was suspected to have soft tissue tumor of the little finger. The lesion could be considered a malignant tumor on the basis of clinical findings.

Interventions:

The patient underwent surgery for exploration and excision of the mass.

Outcomes:

The excised mass was diagnosed to be fibro-osseous pseudotumor of the digit upon histological assessment. Postoperatively, the wound healed without complications. At postoperative 6 months, there were no signs or symptoms of recurrence, and the patient returned to his premorbid functional status.

Conclusion:

Following the detection of a soft tissue mass with clinicopathological features of pseudomalignancy in the digit, clinicians should consider fibro-osseous pseudotumor of the digit as a possible diagnosis, thereby avoiding unnecessary aggressive surgery.
Limitation of non-transplant treatment and proper timing for liver transplantation in patients with hepatocellular carcinoma considering long-term survival
Authors: Nomura Aya , Ishigami Masatoshi , Honda Takashi , Kuzuya Teiji , Ishizu Yoji , Ito Takanori , Kamei Hideya , Onishi Yasuharu , Ogura Yasuhiro , Fujishiro Mitsuhiro
Published: July 2020

In this study, we investigated the long-term survival of patients with hepatocellular carcinoma (HCC) after conventional treatment other than liver transplantation (LT) in our institute and discuss the limitation of non-transplant treatment for HCC and the proper indictors of LT in the recent comprehensive era.

Between 2003 and 2016, 181 patients with HCC aged ≦70 years received active treatment including liver resection, radiofrequency ablation (RFA), and transcatheter arterial chemoembolization (TACE). We analyzed the factors associated with overall survival and proposed new priority for the indicators of LT in HCC patients according to the extracted factors by comparing the survival with 39 transplanted patients with HCC.

Child-Turcotte-Pugh (CTP) score (HR: 1.276; 95% CI: 1.049–1.552, P = .015), and number of tumors (HR: 1.238; 95% CI: 1.112–1.377, P < .001) were selected as significant factors associated with the survival after active treatments for HCC. Patients with LT had significantly better long-term survival compared with those with non-transplant patients regardless of aforementioned factors. However, regarding relatively short survival (3 years), patients with CTP score of ≧9 and/or ≧3 tumors with non-transplant treatment had poorer survival compared with those of transplanted patients (P < .05).

We propose that CTP score of 9 and/or 3 tumors before non-transplant, intensive treatment might be a new priority for considering indicators of LT in patients with HCC.
Responses of metastatic primary fallopian tube carcinoma to pembrolizumab and nab-paclitaxel
Authors: Jiang Jian , Chen Zhi-peng , Zhu Hui-ping , Zhang Yong-qin , Qian Xiao-lan , Zhang Min , Ni Chen , Zuo Yun
Published: July 2020

Rationale:

Primary fallopian tube carcinoma (PFTC) is an extremely rare but invasive malignancy with a dismal prognosis. Very few data exist on the salvage treatment for patients with PFTC. Here we report a case showing an impressive response to immunotherapy combined with chemotherapy, which have never been reported before on patients with metastatic PFTC.

Patient concerns:

A 42-year-old woman, who was diagnosed with PFTC in 2010, had been failed of multiple systemic therapies and antiangiogenic therapy because of the disease recurrence and progression.

Diagnosis:

Metastatic primary fallopian tube carcinoma.

Interventions:

The patient underwent surgery in May 2010 and had multi-line chemotherapies plus an anti-vascular endothelial growth factor (anti-VEGF) monoclonal antibody for about 9 years. Due to treatment failure the patient accepted the immunotherapy with the checkpoint inhibitor, pembrolizumab, combined with nab-paclitaxel from December 2018 to April 2019.

Outcomes:

The patient showed a complete response after 6 cycles, treatment. Thus far, the patient is taking pembrolizumab as maintenance and remains in good health.

Lessons:

Pembrolizumab combined with chemotherapy for treatment of PFTC may provide a positive antitumor effect in multiple metastatic lesions, but more clinical evidence is needed to confirm the efficacy and safety.
Improving FnCas12a genome editing by exonuclease fusion
Authors: Wu Yongqiang , Yuan Qichen , Zhu Yufeng , Gao Xiang , Song Jiabao , Yin Ziru
Published: July 2020

Among current reported Cas12a orthologs, Francisella novicida Cas12a (FnCas12a) is less restricted by protospacer adjacent motif (PAM), which will help target previously inaccessible genomic sites. However, the activity of FnCas12a nuclease is relatively low or undetectable in human cells, limiting its application as desirable genome engineering tools. Here, we describe TEXT (TetheringEXonucleaseT5 with FnCas12a), a fusion strategy that significantly increased the knockout efficiency of FnCas12a in human cells, at multiple genomic loci in three different cell lines. TEXT shows higher insertions and deletions (indels) efficiency than FnCas12a using different spacer lengths from 18nt to 23nt, in which 18nt results in highest fold increase, with up to 11 folds higher efficiency than FnCas12a. Deep sequencing shows that TEXT substantially increased the deletion frequency and deletion size at the targeted locus. TEXT enhances the activity of FnCas12a nuclease and expand its application in human cell genome engineering.
The Phylogenomics of CRISPR-Cas System inSalmonella: an evolutionary race with housekeeping genes
Authors: Kushwaha Simran Krishnakant , Lahiri Chandrajit , Abdella Bahaa , Marathe Sandhya Amol
Published: July 2020

Salmonellaedisplay intricate evolutionary patterns comprising over 2500 serovars having diverse pathogenic profiles. The acquisition/exchange of various virulence factors influence the evolutionary framework. To gain insights into evolution ofSalmonellaas a pathogen in association with the CRISPR-Cas genes we performed phylogenetic surveillance across strains of 22Salmonellaserovars. The strains assorted into two main clades, pertaining to the differences in their CRISPR1-leader andcasoperon. ConsideringSalmonella entericasubsp.entericaserovar Typhimurium and serovar Typhi as signature serovars, we classified the clades as CRISPR1-STM/cas-STM and CRISPR1-STY/cas-STY, respectively. Serovars of the two clades displayed better relatedness, concerning CRISPR-1 leader andcasoperon, across genera than between themselves. This signifies the acquisition of CRISPR1/Cas region a horizontal gene transfer event owing to the presence of mobile genetic elements flanking CRISPR1 array. The CRISPR2 tree does not show such relation. Spacer mapping of the two CRISPR arrays suggests the construct to be canonical, with only 8.8% spacer conservation among the serovars. As opposed to broad-host-range serovars, the host-specific serovars harbor fewer spacers. All typhoidal serovars have CRISPR1-STY/cas-STY system. Comparison of CRISPR andcasphenograms with that of multilocus sequence typing (MLST) suggests differential evolution of CRISPR/Cas system implying supplementary roles beyond immunity.
MARCKS domain phosphorylation regulates the differential interaction of Diacylglycerol Kinase ζ with Rac1, RhoA and Syntrophin
Authors: Ard Ryan , Maillet Jean-Christian , Daher Elias , Phan Michael , Zinoviev Radoslav , Parks Robin J. , Gee Stephen H.
Published: July 2020

Cells can switch between Rac1, lamellipodia-based and RhoA, blebbing-based migration modes but the molecular mechanisms regulating this choice are not fully understood. Diacylglycerol kinase ζ (DGKζ), which phosphorylates diacylglycerol to yield phosphatidic acid, forms independent complexes with Rac1 and RhoA, selectively dissociating each from RhoGDI. DGKζ catalytic activity is required for Rac1 dissociation but is dispensable for RhoA dissociation. Instead, DGKζ functions as a scaffold that stimulates RhoA release by enhancing RhoGDI phosphorylation by protein kinase Cα (PKCα). Here, PKCα-mediated phosphorylation of the DGKζ MARCKS domain increased DGKζ association with RhoA and decreased its interaction with Rac1. The same modification increased binding of the DGKζ C-terminus to the α1-syntrophin PDZ domain. Expression of a phosphomimetic DGKζ mutant stimulated membrane blebbing in mouse embryonic fibroblasts and C2C12 myoblasts, which was augmented by inhibition of endogenous Rac1. DGKζ expression in differentiated C2 myotubes, which have low endogenous Rac1 levels, also induced substantial membrane blebbing via the Rho-ROCK pathway. These events were independent of DGKζ catalytic activity, but dependent upon a functional C-terminal PDZ-binding motif. Rescue of RhoA activity in DGKζ-null cells required the PDZ-binding motif, suggesting syntrophin interaction is necessary for optimal RhoA activation. Collectively, our results define a switch-like mechanism involving DGKζ phosphorylation by PKCα that favours RhoA-driven blebbing over Rac1-driven lamellipodia formation and macropinocytosis. These findings provide a mechanistic basis for the effect of PKCα signaling on Rho GTPase activity and suggest PKCα activity plays a role in the interconversion between Rac1 and RhoA signaling that underlies different migration modes.
Managing corporate brand behavioural integrity: a case of alleged violation of Halal certification
Authors: Butt Muhammad Mohsin , Khong Kok Wei , Alam Muhammad
Published: July 2020

Purpose

This study aims to establish the psychometric properties of behavioural integrity scale at an organizational level from external stakeholders’ perspective and its subsequent influence on consumer trust and commitment with a brand. Moreover, the study also examines how different crisis response strategies moderate the relationship between consumer attributions of the responsibility and corporate brand behavioural integrity in the context of emotional product harm crisis caused by alleged violation of Halal certification by an MNC.

Design/methodology/approach

A quasi-experimental design was applied to test the impact of firm crisis response strategies on its corporate brand behavioural integrity.

Findings

The results provide evidence that behavioural integrity scale can be used to measure consumer perceptions of a corporate brand behavioural integrity. In addition, results indicate that crisis response strategies offer some moderating influence on the relationship between consumer attribution processes and corporate brand behavioural integrity.

Research limitations/implications

Results indicate that existing corporate crisis response strategies are not very helpful in the context of emotional product harm crisis. This study demonstrates that behavioural integrity positively impacts customer relationship-oriented constructs. Furthermore, behavioural integrity scale offers excellent psychometric properties when used at the corporate level.

Practical implications

Organizations can use this proposed conceptual model to monitor and manage behavioural integrity of its corporate brand and its influence on customer-brand relationship constructs.

Originality/value

This study is first of its nature that underscores the importance of measuring and monitoring corporate brand behavioural integrity as a customer trust-building mechanism. It is also the first study that investigates consumer reaction towards alleged brand transgression of its Halal certified product.
Next‐generation sequencing revealing TP53 mutation as potential genetic driver in dermal deep‐seated melanoma arising in giant congenital nevus in adult patients: A unique case report and review of the literature
Authors: Ricci Costantino , Ambrosi Francesca , Grillini Marco , Serra Margherita , Melotti Barbara , Gruppioni Elisa , Altimari Annalisa , Fiorentino Michelangelo , Dika Emi , Lambertini Martina , Corti Barbara
Published: July 2020

Melanoma in giant congenital nevus (M‐GCN) is a rare and potentially lethal neoplasm. In children, M‐GCN appears as a dermal/deep‐seated melanoma (DDM‐GCN) with histopathologic features difficult to distinguish from proliferative nodules (PNs‐GCN). DDM‐GCN in adults is an anecdotal entity and only 8 cases have been described and genetically characterized. We report the first case of DDM‐GCN in a 34‐year‐old man characterized with a large‐panel next‐generation sequence (NGS) highlighting a TP53 mutation with a UV‐signature (C>T substitution) in DDM but not in PNs‐GCN and GCN. Curiously, DDM showed an aberrant p16 overexpression without detection of CDKN2A mutation at NGS. In line with previous studies, it supports a different pathway in children and adults: UV‐induced mutations may be involved in the latter not only by CDKN2A but also by TP53 mutations, with a potentially confusing overexpression of p16 protein. While these data need to be confirmed in larger cases series, our results show that NGS could be an additional genetic diagnostic tool in DDM‐GCN.
STXBP1 encephalopathies: Clinical spectrum, disease mechanisms, and therapeutic strategies
Authors: Abramov Debra , Guiberson Noah Guy Lewis , Burré Jacqueline
Published: July 2020

Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous mutations in the STXBP1 gene include missense, nonsense, frameshift, and splice site mutations, as well as intragenic deletions and duplications and whole‐gene deletions. No genotype–phenotype correlation has been identified so far, and patients are treated by anti‐epileptic drugs because of the lack of a specific disease‐modifying therapy. The molecular disease mechanisms underlying STXBP1‐linked disorders are yet to be fully understood, but both haploinsufficiency and dominant‐negative mechanisms have been proposed. This review focuses on the current understanding of the phenotypic spectrum of STXBP1‐linked disorders, as well as discusses disease mechanisms in the context of the numerous pathways in which STXBP1 functions in the brain. We additionally evaluate the available animal models to study these disorders and highlight potential therapeutic approaches for treating these devastating diseases.

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Modelling of self‐management in schizophrenia: The role of neurocognition, self‐efficacy and motivation
Authors: Zhou Chenxi , Li Zheng
Published: July 2020

Aims and objectives

This study aimed to address the interrelationships among neurocognition, self‐efficacy, motivation and self‐management in individuals with schizophrenia.

Background

Self‐management performance of individuals with schizophrenia is relatively poor. The effect of neurocognitive impairment on self‐management in schizophrenia remains inconsistent, which may be attributed to the neglect of possible mediating factors. Little attention has been given to the role of motivation and self‐efficacy for linking neurocognition to self‐management.

Design

A cross‐sectional study.

Methods

Three hundred and twenty patients were recruited with convenience sampling in this study. Patients’ neurocognitive function, self‐efficacy, motivation and self‐management behaviours were measured. Pearson or Spearman correlation analysis and path analysis were performed to examine the interrelationships. This study followed STROBE checklist for cross‐sectional studies (see Appendix S1).

Results

The final model, with good fit indices, revealed that (1) neurocognition, self‐efficacy and motivation were directly associated with self‐management, (2) self‐efficacy and motivation partly mediated the impact of neurocognition on self‐management and (3) motivation additionally mediated the association of self‐efficacy and self‐management.

Conclusions

Our study extends the current findings, indicating that self‐efficacy and motivation may act as mediators in the relationship between neurocognition and self‐management in schizophrenia.

Relevance to clinical practice

Mental health professionals should pay attention to interventions targeting both cognitive and psychosocial components to enhance self‐management in individuals with schizophrenia.
Changing course
From Here to There
Michael Bond
Belknap Press, 2020. 304 pp.
Authors: Rosen Lawrence
Published: July 2020

Navigational skills require nurturing, lest we lose our way
Immigrants help make America great
Authors: Parikh Sudip
Published: July 2020

I am a scientist. I am an American. And I am the product of special expert visas and chain migration—among the many types of legal immigration into the United States. On 22 June, President Trump issued a proclamation that temporarily restricts many types of legal immigration into the country, including that of scientists and students. This will make America neither greater nor safer—rather, it could make America less so.
Online Optimization with Predictions and Non-convex Losses
Authors: Lin Yiheng , Goel Gautam , Wierman Adam
Published: July 2020

We study online optimization in a setting where an online learner seeks to optimize a per-round hitting cost, which may be nonconvex, while incurring a movement cost when changing actions between rounds. We ask: under what general conditions is it possible for an online learner to leverage predictions of future cost functions in order to achieve near-optimal costs? Prior work has provided nearoptimal online algorithms for specific combinations of assumptions about hitting and switching costs, but no general results are known. In this work, we give two general sufficient conditions that specify a relationship between the hitting and movement costs which guarantees that a new algorithm, Synchronized Fixed Horizon Control (SFHC), achieves a 1 + O(1/w) competitive ratio, where w is the number of predictions available to the learner. Our conditions do not require the cost functions to be convex, and we also derive competitive ratio results for non-convex hitting and movement costs. Our results provide the first constant, dimension-free competitive ratio for online non-convex optimization with movement costs. We also give an example of a natural problem, Convex Body Chasing (CBC), where the sufficient conditions are not satisfied and prove that no online algorithm can have a competitive ratio that converges to 1.
Urodynamic Assessment of Neuronal Intranuclear Inclusion Disease
Authors: Aiba Yosuke , Sakakibara Ryuji , Lee Fang-Ching , Tateno Fuyuki
Published: July 2020

Neuronal intranuclear inclusion disease (NIID) is a disease that causes leukoencephalopathy (dementia) and peripheral neuropathy (variable manifestation including bladder dysfunction). This is the first urodynamic report to show that bladder dysfunction in NIID is a combination of detrusor overactivity, decreased bladder sensation, large post-void residual, and neurogenic changes in the sphincter electromyogram. This report will help managing bladder dysfunction in NIID.
Immunogenicity Evaluation of Chimeric Subunit Vaccine Comprising Adhesion Coli Surface Antigens from Enterotoxigenic Escherichia coli
Authors: Khoobbakht Dorna , Zare Karizi Shohreh , Motamedi Mohammad Javad  , Kazemi Rouhollah , Roghanian Pooneh , Amani Jafar
Published: July 2020

Enterotoxigenic Escherichia coli (ETEC) is the most common agent of diarrhea morbidity in developing countries. ETEC adheres to host intestinal epithelial cells via various colonization factors. The CooD and CotD proteins play a significant role in bacteria binding to the intestinal epithelial cells as adhesin tip subunits of CS1 and CS2 pili. The purpose here was to design a new construction containing cooD and cotD genes and use several types of bioinformatics software to predict the structural and immunological properties of the designed antigen. The fusion gene was synthesized with codon bias of E. coli in order to increase the expression level of the protein. The amino acid sequences, protein structure, and immunogenicity properties of potential antigens were analyzed in silico. The chimeric protein was expressed in E. coliBL21 (DE3). The antigenicity of the recombinant proteins was verified by Western blotting and ELISA. In order to assess the induced immunity, the immunized mice were challenged with wild-type ETEC by an intraperitoneal route. Immunological analyses showed the production of a high titer of IgG serum with no sign of serum-mucosal IgA antibody response. The result of the challenge assay showed that 30% of immunized mice survived. The results of this study showed that CooD-CotD recombinant protein can stimulate immunity against ETEC. The designed chimera could be a prototype for the subunit vaccine, which is worthy of further consideration.
Rhythm Complexity Modulates Behavioral and Neural Dynamics During Auditory–Motor Synchronization
Authors: Mathias Brian , Zamm Anna , Gianferrara Pierre G. , Ross Bernhard , Palmer Caroline
Published: July 2020

We addressed how rhythm complexity influences auditory–motor synchronization in musically trained individuals who perceived and produced complex rhythms while EEG was recorded. Participants first listened to two-part auditory sequences (Listen condition). Each part featured a single pitch presented at a fixed rate; the integer ratio formed between the two rates varied in rhythmic complexity from low (1:1) to moderate (1:2) to high (3:2). One of the two parts occurred at a constant rate across conditions. Then, participants heard the same rhythms as they synchronized their tapping at a fixed rate (Synchronize condition). Finally, they tapped at the same fixed rate (Motor condition). Auditory feedback from their taps was present in all conditions. Behavioral effects of rhythmic complexity were evidenced in all tasks; detection of missing beats (Listen) worsened in the most complex (3:2) rhythm condition, and tap durations (Synchronize) were most variable and least synchronous with stimulus onsets in the 3:2 condition. EEG power spectral density was lowest at the fixed rate during the 3:2 rhythm and greatest during the 1:1 rhythm (Listen and Synchronize). ERP amplitudes corresponding to an N1 time window were smallest for the 3:2 rhythm and greatest for the 1:1 rhythm (Listen). Finally, synchronization accuracy (Synchronize) decreased as amplitudes in the N1 time window became more positive during the high rhythmic complexity condition (3:2). Thus, measures of neural entrainment corresponded to synchronization accuracy, and rhythmic complexity modulated the behavioral and neural measures similarly.
Effect of Tranquil and Active Video Representations of an Unfamiliar Dog on Subjective Mental States
Authors: Ein Natalie , Reed Maureen J. , Vickers Kristin
Published: July 2020

The aim of this pilot study was to examine the effects of different videos of an unfamiliar dog (tranquil and active) on subjective mental state measures. All participants watched two videos of an unfamiliar dog (tranquil and active). Subjective measures of stress, anxiety, alertness, attention, likeability, and cuteness were assessed. The results showed that the tranquil dog video significantly decreased anxiety only. Additionally, the active dog video significantly decreased stress and anxiety. Across the videos, the results showed the active dog video significantly improved subjective alertness and attention when compared with the tranquil dog video. Lastly, the active dog video was rated more likeable and cuter relative to the tranquil dog video. The practical implications of these findings could include how to improve various subjective mental states for humans in public settings (e.g., hospital) where nonhuman animals are not always allowed.
Process Democracy
Authors: Vallier Kevin
Published: July 2020

Democratic theorists have proposed a number of competing justifications for democratic order, but no theory has achieved a consensus. While expecting consensus may be unrealistic, I nonetheless contend that we can make progress in justifying democratic order by applying competing democratic theories to different stages of the democratic process. In particular, I argue that the selection of political officials should be governed in accord with aggregative democracy. This process should prize widespread participation, political equality, and proper preference aggregation. I then argue that the selection of public policies by political officials should be governed in accord with deliberative democracy. This process should prize high quality deliberation and political equality. A process democracy is a democracy that joins an aggregative process for selecting officials with a deliberative process for selecting policies. Democracy is justified and legitimate when it is structured in this way.
Interpretable clinical prediction via attention-based neural network
Authors: Chen Peipei , Dong Wei , Wang Jinliang , Lu Xudong , Kaymak Uzay , Huang Zhengxing
Published: July 2020

Background

The interpretability of results predicted by the machine learning models is vital, especially in the critical fields like healthcare. With the increasingly adoption of electronic healthcare records (EHR) by the medical organizations in the last decade, which accumulated abundant electronic patient data, neural networks or deep learning techniques are gradually being applied to clinical tasks by utilizing the huge potential of EHR data. However, typical deep learning models are black-boxes, which are not transparent and the prediction outcomes of which are difficult to interpret.

Methods

To remedy this limitation, we propose an attention neural network model for interpretable clinical prediction. In detail, the proposed model employs an attention mechanism to capture critical/essential features with their attention signals on the prediction results, such that the predictions generated by the neural network model can be interpretable.

Results

We evaluate our proposed model on a real-world clinical dataset consisting of 736 samples to predict readmissions for heart failure patients. The performance of the proposed model achieved 66.7 and 69.1% in terms of accuracy and AUC, respectively, and outperformed the baseline models. Besides, we displayed patient-specific attention weights, which can not only help clinicians understand the prediction outcomes, but also assist them to select individualized treatment strategies or intervention plans.

Conclusions

The experimental results demonstrate that the proposed model can improve both the prediction performance and interpretability by equipping the model with an attention mechanism.
A síndrome de Cri Du Chat em adolescentes
Authors: Ribeiro Erlane marques , Matos Estela Mares Santos Salmito , Albuquerque Leonardo Siqueira , Carneiro Luzia Julia Porto , Carneiro Regina Coeli de Carvalho Porto
Published: July 2020

Introdução: A síndrome do miado do gato ou síndrome 5p é uma doença congênita rara causada por uma anormalidade cromossômica. Relato do caso: Apresentamos o caso de uma paciente de 13 anos com características dismórficas leves. O retardo mental era grave, com comportamento mal adaptativo e hiperatividade. O diagnóstico citogenético da anormalidade cromossômica 46 XX del 5pter-->p13 foi estabelecido. Conclusão: O diagnóstico precoce dessa doença é necessário para a qualidade de vida dos pacientes, mas esse diagnóstico é difícil de ser realizado em pacientes que foram vistos, pela primeira vez, em idade mais avançada.
Sądownictwo konstytucyjne we Francji po II wojnie światowej
Authors: Jamróz Lech
Published: July 2020

Constitutional Judiciary in France after the Second World War. The Importance of Constitutional Republican Tradition

In France, the institution of the constitutional court appeared relatively late. In the period of the Third Republic, the main obstacle to a serious discussion on the introduction of a constitutional court to the political system was the prevailing concept of a “sovereign parliament” and the associated primacy of the act (statute). The doctrine of those times strengthened the view of the special role of the act (statute) in the legal system; also in the protection of individual rights. These are the main elements of the French republican tradition, which was formed during the Third Republic and was strengthened in the next republican period under the Constitution of 1946. The Constitutional Council, the first independent constitutional court, was introduced into the new system of France (1958) not so much from the conviction of this institution, but from the desire to limit the sovereign power of the parliament and the primacy of the law. The earlier Constitutional Committee (1946) could not fulfill this role, but its importance is underlined in French literature.
ORIENTAÇÃO SEXUAL ESCOLAR E A FORMAÇÃO DE PROFESSORES DE CIÊNCIAS: DA INDIVIDUALIDADE À REFLEXÃO DA PRÁTICA DOCENTE
Authors: Coelho Yuri Cavaleiro de Macêdo , Vasconcelos Sinaida Maria
Published: July 2020

Resumo: A sexualidade humana é um tema cercado de dúvidas e tabus. Por isso, salienta-se a necessidade da inserção do tema, na formação inicial de educadores. Diante disto, investigaram-se, através de uma articulação didática sobre o tema, as percepções, vivências e perspectivas relacionadas à sexualidade, na formação individual e escolar-universitária de futuros professores de ciências. O trabalho empírico envolveu a coleta de dados baseada nas respostas fornecidas pelos acadêmicos a um questionário inicial e nos pontos de vista profissional e pessoal manifestados frente a situações-problemas hipotéticas apresentadas em um debate. As análises e discussão dos dados possibilitaram identificar equívocos na concepção de práticas educacionais que objetivam trabalhar a sexualidade na escola, evidenciando que se deve atribuir maior importância à reflexão da sexualidade, durante o período de formação desses profissionais. Os dados também sugerem que as experiências pessoais e possíveis posicionamentos profissionais dos graduandos se comportam de maneira interdependente e complementar. Registra-se, por fim, que o processo de formação docente como orientador sexual ainda é deficitário, uma vez que os debates dessas temáticas são pouco presentes em disciplinas do currículo tradicional e/ou, muitas vezes, discutidas sob uma perspectiva que distancia a dimensão humana, dialógica, moral e cultural, intrínsecas à sexualidade.  Palavras-Chave: Educação Sexual. Transversalidade. Formação Docente. Abstract:Human sexuality is a subject surrounded by doubts and taboos. Therefore, the need to insert the theme is emphasized in the initial formation of educators. Thus, the aim of this study was to investigate, through a didactic articulation on the subject, the perceptions, experiences and perspectives related to sexuality, in the individual and university-college education of future science teachers. The empirical work involved data collection based on the answers provided by the academics to an initial questionnaire and on the professional and personal points of view expressed in the hypothetical problem situations presented in a debate. The data made it possible to identify misconceptions in the conception of educational practices that aim to work sexuality at school, showing that greater importance should be given to the reflection of sexuality during the period of training of these professionals. The data also suggest that undergraduates' personal experiences and possible professional positions behave in an interdependent and complementary manner. Finally, it is noted that the process of teacher education as a sexual advisor is still deficient, since the debates on these themes are rarely present in traditional curriculum subjects and/or often discussed from a perspective that distances the dimension human, dialogical, moral and cultural, intrinsic to sexuality.Keywords: Sexual Education. Transversality. Teacher Training.
Pies na krótkiej smyczy na chwiejnym mostku
Authors: Muskat Tabakowska Elżbieta
Published: July 2020

Punktem wyjścia artykułu jest tytułowa metafora, której Douglas Hofstadter używa, mówiąc o przekładzie. Hofstadter opisuje zadanie stojące przed tłumaczem, zwłaszcza w przypadku tekstu literackiego, jako dzieło budowniczego mostu, spinającego dwa brzegi kanionu oddzielającego oryginał od przekładu. Konstrukcja, która jest z początku jedynie chwiejną kładką, stopniowo zmienia się w solidny most, w miarę jak tłumacz odkrywa coraz głębsze warstwy znaczeń. Ten proces, nieuchronnie subiektywny, wymaga skupienia uwagi na rozmaitych aspektach przekładanego tekstu. Są one uderzająco podobne do wymiarów obrazowania w modelu gramatyki i języka naturalnego stworzonym przez Ronalda Langackera. W szerszej perspektywie ta zbieżność stanowi argument przemawiający za transdyscyplinarnym podejściem do problematyki przekładu. Pracą tłumacza kierują jego kompetencja, wyobraźnia i empatia, ale jednocześnie podlegają one restrykcjom tytułowej „krótkiej smyczy”: ograniczeniom stwarzanym przez język, ale także przez wymogi określonego kontekstu. Jako ilustrację, autorka przytacza przykłady zaczerpnięte z własnego warsztatu tłumacza. Jest to tekst, w którym różne, a czasem wzajemnie sprzeczne, tożsamości bohaterki wymagają od tłumacza szczególnej uważności wobec leksykalnych i stylistycznych detali. To one tworzą smycz, jednocześnie umożliwiając tłumaczowi budowanie mostu.
Odstępstwa od normy w kategorii gramatycznej liczby w powieści Wojna polsko-ruska pod flagą biało-czerwoną i ich odzwierciedlenie w przekładzie na język rosyjski
Authors: Orzechowska Joanna
Published: July 2020

Dorota Masłowska’s Wojna polsko-ruska pod flagą biało-czerwoną employs various types of linguistic innovations. One of them is a mistaken selection of the number of nouns. This stylistic means results in linguistic humour. In the Russian translation of the novel reflecting this phenomenon should not pose any problems. However, neither of the instances of the stylistic means analysed in the paper was reflected in the Russian target text. It is difficult to determine why the translator did not attempt to show Russian readers a reconstruction of the language of the Polish text. As a result, Irina Lappo’s translation lacks the poetic qualities and refreshing touches of Masłowska’s language.
Identifying Undergraduate Students’ Misconceptions in Understanding Acid Base Materials
Authors: Mubarak S. , Yahdi Y.
Published: July 2020

Students’ misconceptions have become phenomenon in teaching and learning, especially in chemistry which is considered as difficult subject. The objective of this study is to identify undergraduate student’s misconception profiles related to acid-base concepts in inorganic chemistry. This test was conducted with 15 item three tier multiple choices test. Data were identified descriptively and qualitatively. This test instruments are judged as valid with CVR score of 0,99 and mean of 1,73. Meanwhile, the reliability for this instrument varies for each tier combination; for tier one only, r11 was given reliability score for 0,93; for combination tier one and tier two, r11 score was 0,90, and for combination of all tiers, r11 score was 0,81. The test conducted revealed that average percentage of misconception in this test is 33.31% for all items. The highest misconception profile is 60,61% in item no.6 hard soft acid base concept. This includes 15,15% misconception false positive, 9,09% misconception false negative, and 36.36% specific misconception.
Percepção do estudante de enfermagem sobre aprendizagem de liderança nas situações de emergência hospitalar
Authors: De Melo Guilherme Raydan , Sanches Roberta Seron , Fava Silvana Maria Coelho Leite , Costa Andréia Cristina Barbosa , Assunção Munyra Rocha Silva , Lima Rogério Silva
Published: July 2020

Objetivou-se conhecer a percepção dos acadêmicos de enfermagem a respeito da aprendizagem da competência para liderar a equipe de enfermagem nas situações de emergência no ambiente hospitalar. Trata- se de uma pesquisa de abordagem qualitativa, na qual participaram 15 acadêmicos de enfermagem de uma Universidade pública, obtidos a partir de amostra por conveniência. A coleta de dados foi realizada por entrevista semiestruturada, gravada em áudio. Para análise dos dados utilizou-se a Análise Temática. Obteve-se três temas: Liderança do enfermeiro nas situações de emergência: a prática é fundamental; Ser estagiário: “somos mais liderados do que lideramos”; e Potencialidades e fraquezas na aprendizagem da liderança nas situações de emergência. Os estudantes de enfermagem integrantes do estudo reconhecem o papel do enfermeiro como líder nas situações de emergência, enfatizam que a aprendizagem desta competência está relacionada às oportunidades de vivenciar as situações na prática clínica. Contudo, observou-se que as escassas oportunidades de experimentar as emergências associadas à condição de ser estagiário dificultam a aprendizagem do que é ser líder neste contexto assistencial.
Contribuições da simulação móvel para profissionais de saúde e comunidade: protocolo de scoping review
Authors: Silva Cristiane Costa Reis Da , Domingues Fernandes Maria Isabel , Negrão Baptista Rui Carlos , Oliveira Silva Rosana Maria , Hagemann de Malfussi Luciana Bihain
Published: July 2020

O objetivo desta revisão de escopo é identificar e analisar na literatura o emprego da estratégia da simulação móvel para profissionais de saúde e para a comunidade. A simulação clínica é uma forma de metodologia ativa que favorece de forma segura o desenvolvimento de diversas habilidades e competências, tanto para estudantes quanto profissionais de saúde, e auxilia a tomada de decisão possibilitando a repetição da situação simulada sem expor o paciente a erros. A simulação móvel é um campo recente da simulação clínica e diz respeito à simulação que se desloca até os profissionais. A questão que norteia esta revisão é: que contribuições da simulação móvel têm sido identificadas e avaliadas nos processos de formação de profissionais de saúde e da comunidade? O percurso metodológico empregado para o desenvolvimento deste protocolo seguiu as diretrizes do Joanna Briggs Institute para scoping review, composto por cinco etapas: formulação da questão de pesquisa; identificação de estudos relevantes; seleção dos estudos; mapeamento das evidências científicas; apresentação e interpretação dos resultados
La salud y su cuidado como relación cultural intersubjetiva: reflexión fenomenológica en Schütz
Authors: Guerrero Castañeda Raul Fernando , González Soto Cinthia Elizabeth , Jiménez González María de Jesús
Published: July 2020

El objetivo del presente ensayo fue reflexionar en torno a la salud y cuidado como relación cultural intersubjetiva, retomando algunos conceptos de Alfred Schütz como intersubjetividad, cultura y mundo de la vida. La salud comprende un significado objetivo y a la vez uno subjetivo, su cuidado dependerá de la conciencia de las personas y su intencionalidad; además se determina también por una conciencia colectiva. Se destaca el papel de la cultura como una forma de comunicación relacional entre seres humanos y entre varios conocimientos que dependen de las formas de vida que se mantienen por generaciones y que siguen teniendo diversas formas de vivencia de la salud. Se concluye que la salud debe ser un valor en un sentido ampliamente estricto, donde se considere la perspectiva social y la recreación de significados en torno a la vivencia; es decir, la convivencia social otorga significados que son visibles en la vida cotidiana. Es imperante para los profesionales de enfermería y de la salud integrar la cultura como una forma de acercamiento al cuidado de la salud.
Programas de promoção da saúde no ensino superior: uma revisão de escopo
Authors: Evangelista Renata Alessandra , Almeida Macedo Loureiro Helena María , Almeida Silva Luiz , De Assis Bueno Alexandre , Oliveira da Cruz Mendes Aida Maria
Published: July 2020

Objetivo: Mapear e examinar os programas de promoção da saúde ocupacional implementados com professores de instituições de ensino superior. Método: Revisão de escopo, baseado nos procedimentos recomendados pelo Instituto Joanna Briggs. Na busca foram utilizados os MESH: Faculty, Health promotion, Occupational health e Universities, composta por uma combinação de 15 palavras-chaves nas bases de dados MEDLINE, CINAHL, SCOPUS, PsycINFO e Web of Science. A busca manual foi realizada nas bases RCAAP, Banco de Teses da CAPES e periódicos especializados, sem limite temporal. Resultados: Foram encontrados 2498 estudos, sendo 57 lidos na íntegra e 28 compuseram a seleção final. A maioria dos estudos estabeleceu relações de causalidade entre variáveis. O mapeamento dos dados evidenciou um grande número de estudos voltados para a avaliação da saúde e bem-estar da comunidade acadêmica, com desenvolvimento de habilidades individuais e coletivas. O empowerment e as oportunidades de aprendizagem sobre as questões de saúde foram mencionados nas intervenções que visavam à promoção da saúde física e mental e do bem-estar. Conclusões: Todos os programas assumiram que a promoção da literacia influenciava o bem-estar e a qualidade de vida. Este trabalho possibilita nortear as intervenções em saúde ocupacional para criação de ambientes saudáveis e implementação de políticas públicas saudáveis que apoiam e reorientam as condições favoráveis à saúde dos indivíduos e coletividades, além de proporcionarem a promoção de bem-estar e do estilo de vida saudável nas universidades.
Pengaruh Penambahan Arang Aktif Terhadap Mutu Sabun Mandi Cair Rumput Laut (Gracilaria sp.)
Authors: Tanjung Anasri , Prasetyati Sukma Budi , Wardani Ade Kusuma , Saputra Rahmat Surya Hadi
Published: July 2020

Sabun merupakan molekul organik yang terdiri dari dua gugus yaitu gugus polar dan non polar. Formulasi penambahan arang aktif pada sabun mandi cair dipercaya dapat menyerap dan mengangkat kotoran dari permukaan sampai ke dalam pori-pori. Penelitian ini bertujuan untuk memformulasikan pembuatan sabun mandi cair rumput laut dengan penambahan arang aktif, serta melakukan pengujian mutu sabun mandi cair rumput laut yang meliputi pengujian organoleptik, pH, kadar logam merkuri, viskositas dan stabilitas busa. Penelitian dilakukan dari tanggal 11 Maret 2019 sampai dengan 29 Juni 2019 di PT. Rumah Rumput Laut Bogor, dengan bahan baku rumput laut diambil dari Kabupaten Karawang. Penelitian ini menggunakan perlakuan penambahan dan tanpa penambahan arang aktif. Data yang diperoleh kemudian diolah menggunakan statistik untuk mencari nilai rata-rata. Formulasi bahan dalam pembuatan sabun mandi cair rumput laut adalah TEA dan setil alkohol 2.08%, EDTA, sodium klorida dan penoxyetanol 0.98%, gliserin dan VCO 3,47%, esensial oil 0.58%, bubur 23.16%, asam sitrat dan arang aktif 2.32%, aquades 50.96%, KOH 1.97% dan minyak jarak 4.63%. Pengujian mutu yang dilakukan pada sabun mandi cair rumput laut pada laboratorium dengan penambahan arang aktif adalah pH sebesar 9.44, tidak ditemukannya logam merkuri, viskositas sebesar 424 cPs, stabilitas busa sebesar 78.95% dan nilai kesukaan terhadap warna, aroma, kekentalan, jumlah busa, kesan licin, kesan lembut yang ditinggalkan sebesar 6 (suka) dari skala 1 sampai dengan 7.
El respeto: un valor que desafía a la educación de universitarios tabasqueños en la modernidad liquida
Authors: Hernández Romero Gladys
Published: July 2020

Los valores son considerados una guía o patrón de comportamiento que orientan los modos particulares de ser y vivir del individuo. Además, forman el criterio de juicio, preferencia y elección que conducen a una determinada acción. En este sentido, el objetivo de esta investigación es conocer la práctica de valores durante la formación profesional de los universitarios, priorizando el respeto. Para la recolección de datos se aplicó un cuestionario de elaboración propia de ocho ítems a muestra intencional de 100 estudiantes, con edades que oscilaron entre los 18 y los 20 años, dentro de una universidad pública ubicada al sur-sureste de los Estados Unidos Mexicanos. Los resultados señalan que los participantes consideran practicar los valores; sin embargo, estas respuestas llaman poderosamente la atención, ya que en contraparte manifiestan la carencia en prácticas éticas en la convivencia diaria dentro de la institución académica. Dentro de las conclusiones se puntualiza la necesidad de establecer acciones que aminoren la presencia de conflictos en la vida académica y relaciones profesionales, formando así un entorno de ética para la futura generación laboral.