bluuebunny/crossref_metadata_2025 huggingface dataset:
O Debate Pós-democrático no Século XXI
Authors: Ballestrin Luciana
Published: June 2023

Atualmente, observam-se diferentes processos de desdemocratização e autocratização em âmbito global, regional e nacional, os quais colocam um urgente desafio analítico e normativo à disciplina da Ciência Política. O presente artigo observa a importância da introdução da questão neoliberal no debate disciplinar sobre a democracia e sua crise na contemporaneidade, entendendo o neoliberalismo como força desdemocratizante, já há décadas observada nos países latino-americanos. São debatidas as potencialidades e os limites para a aplicação do conceito “pós-democrático” no contexto das democracias situadas no sul global, já que ele carrega um anglo-eurocentrismo metodológico e um liberalismo ideológico particulares às realidades norte-americana e europeia. A ideia de um Brasil pós-democrático é aventada em um exercício interpretativo que adverte para os cuidados da importação teórica não contextualizada histórica e geopoliticamente.
Ativismo Feminista Online: mapeando eixos de atuação
Authors: Sarmento Rayza
Published: June 2023

Este texto busca sistematizar as formas da agência feminista online, entendendo-as como expressão dos feminismos contemporâneos, sobretudo vinculados à experiência de mulheres jovens. Exploramos os fenômenos práticos e os estudos voltados para cinco dimensões, como forma de compreensão mais sistematizada dos elementos e processos políticos e discursivos ligados ao ativismo feminista digital: a) aquele relativo à arquitetura da rede; b) a construção de redes de informação e contranarrativa; c) os grupos de engajamento e solidariedade; d) as campanhas visibilizadas principalmente a partir de hashtags e o e) combate à violência digital de gênero.
Transparência nos municípios brasileiros: as dimensões porte populacional e região importam?
Authors: Nascimento Pedro
Published: June 2023

A transparência é um dos principais mecanismos para o fortalecimento dos regimes democráticos. Ela é entendida como a principal ferramenta capaz de reduzir a assimetria informacional entre Estado e sociedade. Porém, segundo dados da Escala Brasil Transparente (EBT), os municípios brasileiros apresentam baixos índices de transparência. Dessa forma, a presente pesquisa objetivou analisar se os fatores Região e Porte Populacional influenciam nos níveis de transparência desses municípios. A análise foi feita com base nos dados da terceira edição da EBT, e contou com uma amostra de 2.325 municípios. Espera-se que o Porte Populacional e a Região do município influenciem na variação da transparência. Após os testes, foi possível verificar que municípios localizados nas regiões Centro-Oeste e Sul tendem a ser mais transparentes que os localizados em outras regiões. Por outro lado, municípios com porte populacional médio e de grande porte mostraram ser mais transparentes que os demais.
Diversity of Ganglion Cell Responses to Saccade-Like Image Shifts in the Primate Retina
Authors: Krüppel Steffen , Khani Mohammad H. , Karamanlis Dimokratis , Erol Yunus C. , Zapp Sören J. , Mietsch Matthias , Protti Dario A. , Rozenblit Fernando , Gollisch Tim
Published: June 2023

Saccades are a fundamental part of natural vision. They interrupt fixations of the visual gaze and rapidly shift the image that falls onto the retina. These stimulus dynamics can cause activation or suppression of different retinal ganglion cells, but how they affect the encoding of visual information in different types of ganglion cells is largely unknown. Here, we recorded spiking responses to saccade-like shifts of luminance gratings from ganglion cells in isolated marmoset retinas and investigated how the activity depended on the combination of presaccadic and postsaccadic images. All identified cell types, On and Off parasol and midget cells, as well as a type of Large Off cells, displayed distinct response patterns, including particular sensitivity to either the presaccadic or the postsaccadic image or combinations thereof. In addition, Off parasol and Large Off cells, but not On cells, showed pronounced sensitivity to whether the image changed across the transition. Stimulus sensitivity of On cells could be explained based on their responses to step changes in light intensity, whereas Off cells, in particular, parasol and the Large Off cells, seem to be affected by additional interactions that are not triggered during simple light-intensity flashes. Together, our data show that ganglion cells in the primate retina are sensitive to different combinations of presaccadic and postsaccadic visual stimuli. This contributes to the functional diversity of the output signals of the retina and to asymmetries between On and Off pathways and provides evidence of signal processing beyond what is triggered by isolated steps in light intensity.

SIGNIFICANCE STATEMENTSudden eye movements (saccades) shift our direction of gaze, bringing new images in focus on our retinas. To study how retinal neurons deal with these rapid image transitions, we recorded spiking activity from ganglion cells, the output neurons of the retina, in isolated retinas of marmoset monkeys while shifting a projected image in a saccade-like fashion across the retina. We found that the cells do not just respond to the newly fixated image, but that different types of ganglion cells display different sensitivities to the presaccadic and postsaccadic stimulus patterns. Certain Off cells, for example, are sensitive to changes in the image across transitions, which contributes to differences between On and Off information channels and extends the range of encoded stimulus features.
Digitalisierung bei Corporate Mergers & Acquisitions
Authors: Fischer Mirko , Herzfeldt Alexander , Floerecke Sebastian , Ertl Christoph , Beyer Hans-Martin , Klawon Michael
Published: June 2023

Digitalisierung in Corporate Mergers & Acquisitions (M&A)-Prozessen birgt ein erhebliches Potenzial zur Effizienz- und Effektivitätssteigerung, erfährt jedoch bislang in der betrieblichen Praxis nur eine geringe Aufmerksamkeit. Dieser Beitrag schlägt angesichts dessen ein Reifegradmodell vor, womit sich der Ist-Stand der digitalen Reife eines Unternehmens bei Corporate M&A ermitteln und darauf aufbauend Optimierungspotenziale identifizieren lassen. Grundlage der Modellerstellung sind einerseits eine Analyse der vorhandenen Reifegradmodelle und andererseits Interviews mit M&A-Experten unterschiedlicher europäischer Unternehmen.
Tilbes, Surtepe and Tilvez Mounds: An Approach about the Early Bronze Ia-Ib phases, north of Birecik-Carchemish subregion (Southeastern Turkey)
Authors: Gil Fuensanta Jesús , Mederos Martín Alfredo , Uktamovich Muminov Otabek
Published: June 2023

The Early Bronze (EB) I culture in the Turkish Middle Euphrates is of particular importance to our Tilbes Project. Such an archaeological period was discovered in three of the archaeological sites under our supervision. We have been able to differentiate two different moments in the character of the occupation during this Early Bronze Age I, Phases Ia and Ib. The EB Ia phase is characterized by a large urbanization and extensive settlement of the places of Surtepe Höyük, Tilvez/Meteler Höyük and Tilbes Höyük. However, the EB Ib phase, which seems to have continued in at least two of the places, Surtepe and Tilbes Höyük, does not present large remains of monumental architecture and does show an increase in funerary remains in both places. Tilbes Höyük also had, during EB Ia-b, a building with ritual-religious characteristics, built in the same place that was later occupied by BA II and BA III sanctuaries in sector E4a-E8-E3. This area of Birecik is included in the ceramic province of the Late Reserved Slip Ware and indicates a change of orientation of Tilbes and Surtepe towards the Northern Levant, the region of the future kingdom of Ebla, as opposed to the route of the Euphrates, dominant during the Late Chalcolithic.
El viaje diario por el manto del cielo egipcio: nueva aproximación a una estela romana en el Musée du Louvre
Authors: Ortiz-García Jónatan
Published: June 2023

El presente trabajo busca profundizar en el conocimiento de la pervivencia de las creencias y prácticas funerarias de tradición osiriana más allá del Egipto dinástico. En esta ocasión el foco se sitúa en uno de los muchos testimonios de una religiosidad compleja fruto en parte de los contactos entre las distintas comunidades religiosas que coexistían en época romana.Este artículo revisita la iconografía religiosa de una estela funeraria en el Musée du Louvre, que incluye como temas la momificación y el renacimiento astral del difunto a quien perteneció el objeto. En la pieza aparece una posible variante de la ilustración de la recitación 151 del Libro de la Salida al Día a la que se incorporó un motivo relativo a indumentos sagrados y el viaje celeste de los difuntos: un manto como metáfora del cielo por el que transitan los muertos identificados con el sol.
Plurality of Hryhorii Skovoroda`s philosophical practices in the modern reading
Authors: BOICHENKO Mykhailo
Published: June 2023

Hryhorii Skovoroda's philosophy is distinguished by a variety of interests and a combination of different genres of the embodiment of philosophical ideas. Skovoroda's philosophical views were reflected in his various life practices in different ways. And yet these different practices harmoniously support each other, ensuring the successful integral self-support of Hryhorii Skovoroda both as a philosopher and as a person. He highly valued the importance of practice for human improvement, but did not develop a special concept of practice of his own. Since Skovoroda himself did not clearly distinguish different types of practices, it is necessary to reconstruct them based on modern ideas about possible philosophical practices. Among the various types of philosophical practices, which are distinguished by modern philosophy and some signs of which can be found in the life and work of Hryhorii Skovoroda, the following were found: practices similar to avoiding metanarratives; practices similar to deconstruction; practices of metaphorization; informational diet practices; improvisation practices; practices of avoiding the effects of the society of the spectacle; spiritual self-reference practices; critical thinking practices; social networking practices. The article attempts a reverse theoretical reconstruction of Hryhorii Skovoroda's philosophical practices. That is, from the standpoint of modern philosophical concepts, the meaning of those life practices that Hryhorii Skovoroda adhered to when he embodied his philosophical views in his actions, mostly without unnecessary declarations, has been partially reconstructed. Skovoroda's practical philosophy was not built by him as a theoretical system, although his life clearly shows the coherence of various life practices. All the practices followed by Hryhorii Skovoroda were fundamentally philosophical – he lived like a philosopher and approached everything like a philosopher, with a philosophical heart and a philosophical head. There were many of these practices, and this article mentions only some of them, namely those that seem significant to us today in the light of the later development of European philosophy – as we know it to this day. It is quite likely that other philosophers of our time, and even more so philosophers of the future, will see in Skovoroda's philosophical life also other various practices.
Child Pedestrian Safety
Authors: Kendi Sadiqa , Johnston Brian D. ,   COUNCIL ON INJURY, VIOLENCE, AND POISON PREVENTION, Hoffman Benjamin , Agran Phyllis F. , Culyba Alison , Dodington James , Lee Lois K. , McFadden Terri , Monroe Kathy , Tenenbein Milton , Quinlan Kyran , Beno Suzanne , Dixon Cinnamon , Dunn Laura , Midgett Jonathan D. , Miller Bethany , Qualters Judith , Kozial Bonnie
Published: June 2023

The field of pedestrian safety has advanced with new evidence related to pediatric pedestrian education, the risks of distracted walking, the benefits of design and programming in safe routes to school, and the emergence of the “Vision Zero” strategy to eliminate all traffic fatalities and severe injuries while increasing safe, healthy, equitable mobility for all.

This statement is a revision of the 2009 American Academy of Pediatrics policy statement “Pedestrian Safety” and is accompanied by a technical report (www.pediatrics.org/cgi/doi/10.1542/peds.2023-062508) providing additional detail to support recommendations. This statement is intended to assist practicing pediatricians to offer evidence-based advice to families about the benefits of active transportation and the specific risks and safety precautions to consider for child pedestrians at different ages. For community pediatricians and the American Academy of Pediatrics, the statement provides an overview of specific programs and policies that, if implemented, could foster independent mobility for children while increasing pediatric pedestrian safety. This statement identifies trends in public health and urban design relevant to pedestrian safety.
WebMRI: Brain extraction and linear registration in the web browser
Authors: Harmouche Ahmed , Kövér Ferenc , Szukits Sándor , Dóczi Tamás , Bogner Péter , Tóth Arnold
Published: June 2023

Background and Aim

Since the initial release of the World Wide Web, the capabilities of web browsers have grown from presenting formatted documents to running complex programs, such as 3D game engines. The medical imaging community started to adopt technologies that came with the fifth major version of the HyperText Markup Language (HTML5). It led to the creation of various web-based radiological applications such as cornerstone.js or BrainBrowser. BrainBrowser supports both 3D and 2D rendering of neuroimaging data. However, it cannot run important image processing algorithms, such as brain extraction and linear registration, which are essential in most neuroimaging workflows. The most commonly used library that supports these algorithms is the FMRIB Software Library (FSL). We aim to build a web-based cross-platform neuroimaging platform that combines data visualization with image processing.

Methods

We built our system as an extension of BrainBrowser. We developed WebMRI in JavaScript and designed the user interface using HTML, CSS, and Bootstrap. We used Emscripten to port the brain extraction and linear registration tools of FSL to the web.

Results

We built WebMRI, a fully web-based extensible neuroimaging platform that combines the visualization capabilities of BrainBrowser with the brain extraction and linear registration tools of FSL by porting them from C++ to WebAssembly. We extended BrainBrowser with a plugin system that makes it easy to bring other processing algorithms into the platform. We released the WebMRI source code on Github: https://github.com/wpmed92/WebMRI.

Conclusions

We developed and released WebMRI, a web-based cross-platform open-source neuroimaging platform.
Pemberdayaan Potensi Sosial Masyarakat Melalui Yayasan Aksi Cepat Tanggap (ACT) Bandung
Authors: Nuraeni Irma , Safei Agus Ahmad , Aziz Rohmanur
Published: June 2023

Humanity issue is the main things that need to be developed for the development of community welfare in the social, educational, economic and religious fields. This writing aims to find out the existence of the Aksi Cepat Tanggap Foundation (ACT) in the midst of the Bandung community in developing the potential and development of a strong civil society which has the potential to empower and develop the community. The research method used is a field study method by conducting surveys, interviews and documentation directly to the Foundation branch office. Data processing and analysis includes the process of collecting data, classifying data, connecting data with one another, analyzing data, and drawing conclusions. So it can be concluded that with the role of social capital, trust, accountability and transparency improve the condition of community welfare.
Program Pemberdayaan Masyarakat Difabel Melalui Difabel Creative Center di Daarut Tauhiid
Authors: Bisqi Muhammad Rival , Rifa’i A.Bachrun , Azis Ali
Published: June 2023

The aim of this research is to find out the process, implementation and results of community empowerment through the disabled creative center (DCC) program which is specifically for people with disabilities in the city of Bandung and is managed by DT – Peduli. The research method uses a descriptive method with a qualitative approach. The results showed that the DCC program took the form of sewing skills training, screen printing training, clothing production, and marketing of products. With the implementation, this meeting is carried out on a scheduled and neatly packaged basis which is inserted with a program of guidance on physical and spiritual motivation in the form of mini seminars, workshops or thematic training guided by successful experts and practitioners and Second, the Disability Workshop is a space to facilitate the potential possessed by the participants or DCC alumni so they can display their superior products or expertise profiles offline and online. As for the results of the DCC program, people with disabilities in the city of Bandung are able to improve their standard of living and are more empowered after participating in the disabled creative center (DCC) program.
ASSESSMENT OF FARMERS’ PERCEPTIONS CONCERNING POTATO FARMING SYSTEMS IN NORTH WESTERN ETHIOPIA
Authors:   Debre Tabor University, Aragaw Momina , Abebe Tesfaye ,   Holetta Agricultural Research Center Adet Agricultural Research Center, Worku Wallelign ,   Hawassa University, Amare Tadele ,   Holetta Agricultural Research Center Adet Agricultural Research Center
Published: June 2023

Aim of the study Assessing the perception of north western Ethiopia farmers’ on the role of potato in the farming system Material and methods: Elders with different socioeconomic back grounds and experience on potato production were used for this study. A proportional allocation formula was employed. Data was collected from both primary and secondary sources. Primary sources of data were collected. The questionnaire constituted open ended questions to allow full expression about the issue. Discussions were made with farmers, agricultural extension officers, researchers, and potato experts. All sets of data were subjected to Statistical Package for the Social Sciences (SPSS), Version 24 computer software (20) and descriptive statistics such as mean, standard deviation and frequency were used to analyze the collected data. Class intervals were used to analyze descriptive statistics for age, education level, family size, etc. Results and conclusions: The survey also revealed that farmers use potato in soil fertility management, had their own local varieties and different variety preferences. They were losing such local potato varieties which had different quality attributes to be used in different breeding/agronomy programmes and best fit to degraded lands. More frequency of ploughing causes soil and nutrient erosion. The study also revealed that there were traditional techniques of soil fertility management like terracing, fertilization and crop rotation mainly with potato. Farmers in the surveyed area believed that potato can ameliorate the fertility of the soil and protect soils from erosion. Researches should be conducted to minimize number of ploughing in potato production.
Successful transcatheter aortic valve replacement in a patient with radiation-induced aortic stenosis
Authors: Zubarev D. D. , Sim S. V. , Krasnov V. S. , Gorbatykh A. V. , Chernyavsky M. A. , Prokhorikhin A. A.
Published: June 2023

Aortic stenosis is one of the most common valvular heart defects that occurs in patients with oncology after radiation therapy and requires surgical treatment. However, this group of patients has a higher risk of intra- and postoperative complications, and therefore the most optimal method of surgical treatment of aortic stenosis in such a cohort of patients is transcatheter aortic valve implan­tation (TAVI).

Brief description. Forty-six-year old woman entered the Almazov National Medi­cal Research Center with a clinical picture of severe aortic stenosis. At a young age, the patient was diagnosed with lymphogranulomatosis, or Hodgkin’s disease, for which radiation therapy was performed, which was complicated in the long term by valvular pathology. After a thorough examination, a high intraoperative risk for the patient was determined by the cardiac team and endovascular treatment of severe aortic stenosis was performed. The postoperative period was complicated by the development of complete atrioventricular block, which caused the implantation of a permanent dual-chamber pacemaker.

Discussion. The presented case is an example of successful surgical treatment of aortic stenosis associated with previous radiation therapy for Hodgkin’s disease in a patient.

Conclusion. Endovascular aortic valve implantation is a promising approach to the treatment of patients with post-radiation aortic stenosis, since it is associated with unfavorable anatomical and clinical risk factors for surgical valve replacement. Despite their younger age, these patients represent a category of higher surgical risk. Therefore, additional attention should be paid to the planning of the procedure and the prevention of the main TAVI risks.
Short‑to‑mid‑term follow‑up results of transcatheter closure of atrial septal defect in patients older than 60 years
Authors: Le T. K. , Nguyen Minh N. , Hoang T. H.
Published: June 2023

Aim. To assess short-to-mid-term clinical and echocardiographic outcomes and identify factors associated with pulmonary arterial hypertension (PAH) in patients older than 60 years.

Material and methods. Retrospective single-center study of 51 consecutive patients (mean age 63,3±3,2 years, 76% females) undergoing percutaneous ASD closure. Functional status, right ventricular (RV) remodeling and pulmonary artery systolic pressure (PASP) was assessed before and 24 hours after the procedure, at 6 months and 12 months.

Results. The mean ASD size was 21,8±4,4 mm. Compared to before procedure, at 24 hours a significant improvement of NYHA class (NYHA II-III 7 (13,7%) vs. 34 (66,7%) patients, p<0,0001, respectively), RV size (26,9±5,7 vs. 31,3±5,7 mm, p<0,0001, respectively) and PASP (26,9±5,7 vs. 50,4±14,2 mm Hg, p<0,001) was detected. At 1 year, RV size and PASP decreased to 22±4,6 mm, p<0,0001 and 33,8±10,8 mm Hg, p<0,0001, respectively, compared to before ASD closure, PAH remained in 10 (19,6%) patients. Pre-intervention PASP ≥57,5 mm Hg was an independent predictor of residual PAH at 1 year (odds ratio 1,31, 95% confidence interval (CI) 1,04-1,67, p=0,024; c-statistics 0,939, 95% CI 0,865-1,0, p<0,001, sensitivity 80%, specificity 92,6%).

Conclusion. Percutaneous ASD closure in elderly patients was associated with regression of RV size and PASP, as well as symptomatic improvement in the short- and medium-term. Pre-intervention PASP was an independent predictor associated with residual PAH after one year.
Antiplatelet therapy de-escalation in a patient after percutaneous coronary intervention with a high risk of bleeding
Authors: Kassymova A. A. , Mansurova J. A. , Karazhanova L. K. , Chinybayeva A. A.
Published: June 2023

According to recommendations of ESC 2020-year, de-escalation of therapy with a P2Y12 receptor inhibitor (transition from prasugrel or ticagrelor to clopidogrel) It can be considered as an alternative strategy of dual antiplatelet therapy (DAPT) for patients with acute coronary syndrome (ACS) who are unsuitable for the use of a strong platelet inhibitor.

De-escalation can be performed based on an individual clinical evaluation under the supervision of platelet function testing or CYP2C19 genotyping, depending on the patient’s risk profile and the availability of appropriate diagnostic methods. The optimal dosage of strong P2Y12 receptor inhibitors, such as ticagrelor or prasugrel is not entirely clear and is especially difficult to define for patients of Asian nationality.

The article describes a clinical case of antiplatelet therapy de-escalation, particularly a dose reduction of the potent P2Y12 receptor inhibitor ticagrelor in a patient after percutaneous coronary intervention (PCI) with a high risk of bleeding based on platelet function determination and genetic testing. A 47-year-old patient of Kazakh nationality was hospitalized with gastrointestinal bleeding.

Given bleeding type 3 by BARC (Bleeding Academic Research Consortium) associated with DAPT, it was decided to apply a strategy to de-escalate antiplatelet therapy under the control of platelet function testing (PFT) and genetic testing.

In this case, replacement of ticagrelor with the weak P2Y12 receptor inhibitor clopidogrel was not possible as the patient appeared to be a carrier of the CYP2C19*2 polymorphism contributing to loss of function of the cytochrome P-450(CYP) enzyme.
Retrospective analysis of the prevalence of ischemic stroke and the appointment of anticoagulant therapy in patients with atrial fibrillation depending on the body mass index
Authors: Druzhilov M. A. , Kuznetsova T. Yu. , Druzhilova O. Yu. , Tsarkova M. K. , Gavrilov D. V. , Gusev A. V.
Published: June 2023

Aim. To estimate the prevalence of ischemic stroke (IS) and the appointment of anticoagulant therapy in patients with atrial fibrillation (AF) depending on body mass index (BMI) as part of a retrospective analysis of big data from certain subjects of the Russian Federation using artificial intelligence technologies.

Material and methods. The information was obtained from the Webiomed predictive analytics platform, which includes depersonalized data from electronic health records of patients in 6 Russian constituent, extracted using artificial intelligence technologies. Individuals with AF aged ≥18 years were selected with available data on BMI of 18,5-60,0 kg/m2 inclusive (n=56003; men, 41,0%; age, 67,4±14,5 years, CHA2DS2-VASc score, 3,4±1,8). The following BMI ranges were identified: 18,5-21,9 kg/m2, 22,0-24,9 kg/m2 (taken as a reference), 25,0-29,9 kg/m2, 30,0-34,9 kg/m2, 35,0-39,9 kg/m2 and 40,0-60,0 kg/m2. The indicators were analyzed in age ranges (≤64 years, 65-74 years, ≥75 years) separately among men and women.

Results. Among men ≤64 years of age, patients with overweight and class 2 obesity were characterized by a significantly higher incidence of IS. Among women ≤64 years, a significantly higher frequency of IS was found in subgroups with overweight and class 1-3 obesity, while among women aged 65-74 years — in a subgroup with a BMI of 18,5-21,9 kg/m2. Patients aged ≥75 years showed an insignificant trend towards the maximum frequency of IS with a BMI of 18,5-21,9 kg/m2. A higher frequency of anticoagulant therapy prescription was found in subgroups with overweight and class 1-3 obesity; in most age and sex subgroups, the differences are significant. A significantly lower frequency of anticoagulant therapy prescription to persons ≥75 years of age with a BMI of 18,5-21,9 kg/m2 was noted.

Conclusion. The study showed a significant BMI paradox in the context of the relationship between the frequency of IS and BMI value in patients with AF. A higher incidence of IS in persons ≤64 years of age with a BMI ≥25 kg/m2 compared with pa­tients with normal weight may be an additional argument for establishing an inde­pen­-dent prognostic role of obesity in the development of thromboembolic events in AF.
Factors determining adherence to anticoagulant therapy in patients with atrial fibrillation
Authors: Pevzner D. V. , Kostritsa N. S. , Galaeva L. M. , Merkulova I. A. , Dorogun O. B. , Krasnoperova E. V. , Komarov A. L.
Published: June 2023

Aim. To identify risk factors for low adherence and develop a scale for its pre­diction. To evaluate the association of the predictive score with actual low adherence according to the 8-item Morisky Medication Adherence Scale, self-drug withdrawal, and adverse outcomes in patients with atrial fibrillation (AF).

Material and methods. The study included patients with AF and a high risk of thromboembolic events according to the CHA2DS2-VASc scale, who were hospitalized from January 2011 to December 2017. Potential risk factors for non-adherence, selected from the literature, were tested in a multivariate regression analysis followed by the development of an adherence prediction scale. The asso­ciation of predicted low adherence with actual adherence was assessed.

Results. The study included 199 patients. The analysis identified following predictors of low adherence: low income, history of bleeding, prior stroke, 4 positive responses to the adherence questionnaire, warfarin. Based on these predictors, a scale for predicting adherence was developed, while a threshold value of 3 points was identified (sensitivity, 90,2%, specificity, 98,4%). A significant association of low predicted adherence on the developed scale with actual adherence and adverse outcomes was demonstrated.

Conclusion. We have developed a scale for predicting adherence to anticoagulant therapy, and also determined its threshold value. In case of a high risk of low adherence, clinicians should try to increase adherence in order to prevent comp­lications.
Modern approaches to interpretation of clinical trial results to evaluate the effectiveness of heart failure therapy. Analysis of the results of randomized trials PARADIGM-HF, DAPA-HF, EMPEROR-Reduced and VICTORIA
Authors: Gilyarevsky S. R. , Mareev Yu. V.
Published: June 2023

The article discusses the results of modern studies evaluating the effectiveness of drug therapy for heart failure with reduced ejection fraction (HFrEF). Modern approaches to a comprehensive evaluation of data obtained in various randomized clinical trials (RCTs) are presented. The role of methods for presenting the RCT results is considered, as well as the difference between hazard ratio and relative risk is clarified. Expert opinions are discussed about the limitations of simplified approaches to comparing the results of large RCTs, which are based only on comparisons of hazard ratio without taking consideration of patient characteristics, study duration, and the absolute number of adverse outcomes that developed. Information is provided on the role of accounting for multiple comparisons in assessing clinical outcomes in RCTs. The article compares the VICTORIA results on the study of vericiguat in patients with a recent episode of HFrEF decompensation with RCTs on the evaluation of the effects of drugs that are part of standard therapy.
DX single-lead implantable cardioverter-defibrillator system with a floating atrial dipole: when, to whom, and why?
Authors: Prokopenko A. V. , Ivanitsky E. A.
Published: June 2023

The article reflects information for cardiologists, cardiac surgeons, doctors pro­gramming implanted antiarrhythmic devices, employees and residents of the depart­ments of cardiology and cardiac surgery. Most often, we choose a model of an implantable cardioverter-defibrillator (ICD) strictly individually for each patient, based on the anamnesis characteristics, safety and highest efficiency of ICD systems offered on the market. With each new ICD model, manufacturing companies strive to minimize the number of implantable components and develop better algorithms to discriminate between atrial tachyarrhythmias and true ventricular tachyarrhythmias. However, the risk of inappropriate ICD therapy still remains high. Thus, attending physicians and cardiologists programming implantable antiarrhythmic devices often face difficulties in correcting ICD settings and planning further treatment of a patient with shocks caused by atrial tachyarrhythmias. The authors sought to form an idea about the features of a single-chamber ICD recording atrial potentials using a floating dipole, as well as the advantages of the DX system over classical single-chamber ICD systems, and to define a type of a patient for whom this implantable system would be the best choice preventing sudden cardiac death.
Review of 20-year results of ASCOT Legacy
Authors: Nagorny M. B. , Kuchmin A. N.
Published: June 2023

The article presents the results of a 20-year follow-up of patients in the ASCOT Legacy study, indicating that antihypertensive and lipid-lowering therapy reduces mortality in patients with hypertension and high cardiovascular risk in the long term. In the group of patients treated with amlodipine compared with the β-blocker atenolol, there was a decrease in mean systolic and diastolic blood pressure (BP), as well as a long-term improve in the form of a decrease in the prevalence of cardiovascular events and mortality due to stroke. An important feature of therapy based on amlodipine was the reduction in BP variability. The article reflects the results of major studies that determine the possibility and effectiveness of early prescription of combined antihypertensive and lipid-lowering therapy.
New Meta-heuristic - Based Approach for Identification and Control of Stable and Unstable Systems
Authors: Azegmout Mohamed , Mjahed Mostafa , El Kari Abdeljalil , Ayad Hassan
Published: June 2023

Nowadays, the use of meta-heuristic algorithms (MAs) for tackling complicated engineering issues has shown significant promise, therefore applying MAs to optimum model parameters and PID parameters can be quite beneficial. As a result, this paper looks at the capabilities of four recently released resilient MAs in optimizing model parameters and PID parameters for various system behaviors. Hence, these four meta-heuristic algorithms are used such as Ant Colony Optimization (ACO), Cultural Algorithm (CA), Invasive Weed Optimization (IWO), and Black Hole Algorithm (BHA). The key contribution of this study is the employment of many meta-heuristics at the same time with the same objective function while taking into consideration each algorithm parameters for identification and control, then compared to traditional techniques such as Least square (LS) and Reference Model (RM). Thus, the most efficient algorithm is the one that yields the lowest cost function, has the lowest standard deviation (SD), and uses the least amount of CPU time. Regarding identification, simulation findings showed that CA algorithm has the best cost, lowest standard deviation (SD) and fewest CPU time 2.7838e-13, 7.1108e-13 and 3.1395(s), respectively. As for control system, it is shown that created intelligent-based controllers are more dependable than reference model controllers in stabilizing the behaviors of the various examined processes, with the IWO algorithm finds the best gains of PID and converges the fastest with best cost 3.2905e-10 and CPU time 48.8732(s). Moreover, ACO and BHA both failed to achieve satisfactory results in terms of accuracy and CPU time compared to others algorithms. Additionally, studies also showed that optimization methods has good performance, resilient and effective.
Gestalt Principles Governed Fitness Function for Genetic Pythagorean Neutrosophic WASPAS Game Scene Generation
Authors: Petrovas Aurimas , Bausys Romualdas , Zavadskas Edmundas
Published: June 2023

The maintenance of visual appeal and coherence in the procedural game scene generation is still a difficult problem. Traditional procedural game scene generation algorithms produce samples that show a noticeable resemblance to each other. The proposed algorithm allows us to add diverse game object compositions and increase creativity value in that way. Result diversity is formed by the proposed genetic algorithm modification and MCDM method based on the fitness function. Video game immersion is reached by aesthetic game element pattern composition, and one of the solutions for this issue is to apply automated aesthetic modelling of the generated game levels. In this research, the construction of fitness function was extended by the modelling of aesthetic principles, which were reverse-engineered from Gestalt principles. All rules were implemented by construction of a focal function with a square zone for each matrix cell of the single game scene. Five types of Gestalt rules were modelled and combined into a Pythagorean neutrosophic WASPAS method and the final score calculation algorithm was proposed. The proposed approach to generating game scenes strikes a balance between functionality and aesthetics to provide players with an engaging and immersive gaming experience.
Influencer Kaynak Güvenilirliği ve Marka Tutumunun Satın Alma Niyeti Üzerindeki Etkisi
Authors: SARIOĞLU Cüneyd İkbal
Published: June 2023

Son yıllarda pazarlama alanında yenilikler, teknoloji ve sosyal medya alanlarındaki açılımlarla devam etmektedir. Bu yeniliklerden birisi olan sosyal medya fenomeni ya da yaygın ismiyle influencer (sosyal etkileyici) pazarlama kavramı giderek yaygınlaşmaktadır. Markaların ön plana çıkarak marka tutumunun oluşması ve kalıcı olmasında influencer kaynak güvenliğinin sağlanması önemli rol oynamaktadır. Influencer kaynak güvenilirliği; güvenilirlik, çekicilik, uzmanlık ve online benlik sunumu şeklinde ele alınmıştır. Bu çalışmada, influencer kaynak güvenilirliği boyutlarının ve marka tutumun satın alma niyeti üzerindeki etkisinin ortaya çıkarılması amaçlanmaktadır. Bu bağlamda, internet üzerinde yapılan anketlerden dönüş sağlayan toplam 3127 katılımcı analize dâhil edilmiştir. Yapılan analizler sonucunda, oluşturulan hipotezler, ikisi hariç kabul edilmiştir. Buna göre, influencer kaynak güvenilirliğinin 2 alt boyutu olan güvenilirlik ve çekicilik değişkenleri ile marka tutumu, tüketicilerin satın alma niyeti üzerinde pozitif etkide bulunmaktadır. Araştırma sonuçlarına göre, influencer pazarlamasında kaynak güvenilirliğinin çok önemli olduğu ve kaynak güvenilirliğini oluşturan alt boyutlar olan güvenilirlik ve çekicilik konusunda tüketicilere pozitif algılamalar verildiğinde, marka tutumu ve nihai olarak satın alma niyetinin pozitif olarak etkileneceği görülmüştür. Bu çalışma, pazarlamadaki yeni ve önemli gelişmelerden birisi olan influencer güvenilirliğini marka tutumuyla birlikte satın alma niyetine etkisini araştırdığı için literatüre katkı yapmaktadır. Bulgular değerlendirildiğinde pazarlama faaliyetlerinde influencer pazarlamanın kaynak güvenilirliği açısından nasıl olması gerektiği konusunda tavsiyelerde bulunulabilir. İnfluencerların öncelikle çekici ve güvenilir olması, satın alma niyeti ve marka tutumu açısından tüketici davranışlarını olumlu yönde etkilemektedir. İşletmelerin bu sonuçları değerlendirerek influencer pazarlama faaliyetlerini planlaması önerilmektedir. Burada özellikle influencerların reklamını yapacakları marka ile uyumlu olması önem arz etmektedir.
FETAL ECG EXTRACTION FROM THE ABDOMINAL SIGNAL USING WAVELET BISPECTRUM TECHNIQUE
Authors: Viunytskyi O. G. , Shulgin V. I. , Roienko A.A. , Totsky Alexander V. , Eguiazarian K. O.
Published: June 2023

The paper is devoted to the issues of digital signal processing in noninvasive fetal electrocardiography (NI-FECG) during pregnancy. This technology has been attracting more and more attention, both from doctors of perinatal medicine and specialists in the field of electrophysiological signal processing. The former is interested in it as a new informative tool for diagnosing the condition of the fetus and various disorders of the course of pregnancy and the latter as a new field of application of modern signal processing techniques. A novel technique for filtering the FECG signal extracted during NI-FECG and detecting Q-wave R-wave S-wave (QRS) of ventricular complexes of FECG based on combined wavelet bispectrum processing strategy is proposed and studied. New algorithms were used in the prototype of the developed NI-FECG system. The proposed algorithms have shown their efficiency and high quality of FECG extraction and filtering.
Dibujo para estudiantes de ingeniería: representación gráfica
Authors:   Universidad Cooperativa de Colombia, Rozo Martínez Leandro Raúl
Published: June 2023

Con el paso del tiempo, la ingeniería civil ha venido innovando en los procesos de construcción con el propósito de mejorar su eficiencia. Por esa razón, los estudiantes de ingeniería, además de adquirir conocimientos base, deben desarrollar habilidades para el uso de herramientas empleadas en diseños de ingeniería civil. La presente guía dispone de las instrucciones necesarias para adentrar al estudiante en su primera experiencia de representación de esquemas gráficos de dibujos de ingeniería, lo cual permitirá descubrir las capacidades, habilidades y destrezas que cada individuo posee dentro de esta área base. Se abordan el origen y descubrimiento de las primeras representaciones gráficas encontradas por la humanidad; los tipos de líneas, incluyendo consulta temática y desarrollo de ejercicios iniciales de trazos a mano alzada y con el uso de herramientas; los círculos y su importancia, con los ejercicios respectivos; y la historia de la aparición de las letras y el alfabeto, que incluye ejercicios de letra técnica empleada en formatos de dibujo en ingeniería. Finalmente, a través del desarrollo temático y de los ejercicios de práctica, el estudiante podrá indagar y comparar las ventajas y desventajas de los medios de representación gráfica con base en su primera experiencia, en el papel que han desempeñado y en la investigación realizada.
Rousseau’s Pygmalion as Research on Stage: From Theory to Practice and Back Again
Authors: Gullstam Maria
Published: June 2023

This chapter discusses the historical sources that were used for Performing Premodernity’s production of Jean-Jacques Rousseau’s Pygmalion (1762/1770) and the way the practical work influenced the group’s understanding of the scène lyrique. Studying video recordings of the production, and reflecting on the continued collaboration with the performers, the author delves into the question of why her emotional response to the production grew stronger over the years.
Swimming in the Water of Theatrical Conventions: The Performers’ Perspective
Authors: Sauter Willmar , Schneider Magnus Tessing
Published: June 2023

In this interview, the singer-actors João Luís Paixão and Laila Cathleen Neuman describe their experience of taking part in the workshop experiments of the research group Performing Premodernity as well as in the group’s production of Jean-Jacques Rousseau’s Pygmalion, which premiered at the State Castle of Český Krumlov in 2015. The conversation revolves around the scenic interpretation of Pygmalion and the genre of melodrama at large and about what the singers learned about eighteenth-century acting from performing at the Drottningholm Palace Theatre and in other historic theatre sites.
Presenting the Theatre of Drottningholm
Authors: Wiles David
Published: June 2023

A transcript of the keynote lecture given to the International Federation for Theatre Research which met in Stockholm in 2016. The lecture introduced delegates to the Theatre of Drottningholm, presenting it not as inert heritage but as a living laboratory for exploring eighteenth-century acting. Staged excerpts from Handel, Rameau, and Rousseau’s Pygmalion demonstrate how language was harnessed to gesture in order to distinguish and embody human passions. This was not a static system of acting but kept changing, and the theatre architecture itself reflects a tension between different historical ideals.
Navigating Personal Health Crises, Imposter Syndrome, Sexual Harassment, Clinical Mistakes and Leadership Challenges: Lessons for Work-Life Wellness in Academic Medicine: Part 3 of 3
Authors: Barach Paul , Ahmed Rami , Agarwal Gaurava , Olson Kristine , Welch Julie , Chernoby Kimberly , Hein Christine , Anand Tanya , Joseph Bellal , Rosenstein Donald , Sotto-Santiago Sylk , Hartsock Jane , Holmes Emily , Schroeder Kristen , Hartwell Jennifer
Published: June 2023

In this final manuscript of the three-part series, the authors address issues of imposter syndrome, pregnancy, and parental leave, second victim phenomenon, sexual harassment, response to suicide, and managing a budget while advancing diversity, equity, and inclusion. The case scenarios have learners and non-clinicians as their main characters, bringing attention to the cross-cutting nature of the complex issues we see both in and around a career in medicine.
The Identifiability of Mathematical Models in Epidemiology: Tuberculosis, HIV, COVID-19
Authors: Krivorotko Olga , Kabanikhin Sergey , Petrakova Victoriya
Published: June 2023

The paper is devoted to the short review and application of sensitivity-based identifiability approaches for analyzing mathematical models of epidemiology and related processes described by systems of differential equations and agent-based models. It is shown that for structural identifiability of basic SIR models (describe the dynamic of Susceptible, Infected and Removed groups based on nonlinear ordinary differential equations) of epidemic spread and linear compartmental models it is possible to use a priori information about the process. It is demonstrated that a model can be structurally identifiable but be practically non-identifiable due to incomplete data. The paper uses methods for analyzing the sensitivity of parameters to data variation, as well as analyzing the sensitivity of model states to parameter variation, based on linear and differential algebra, Bayesian, and Monte Carlo approaches. It was shown that in the SEIR-HCD model of COVID-19 propagation, described by a system of seven ordinary differential equations and based on the mass balance law, the parameter of humoral immunity acquisition is the least sensitive to changes in the number of diagnosed, critical and mortality cases of COVID-19. The spatial SEIR-HCD model of COVID-19 propagation demonstrated an increase the sensitivity of the partial immunity duration parameter over time, as well as a decrease in the limits of change in the infectivity and infection parameters. In the case of the SEIR-HCD mean-field model of COVID-19 propagation, the sensitivity of the system to the self-isolation index and the lack of sensitivity of the stochastic parameters of the system are shown. In the case of the agent-based COVID-19 propagation model, the change in the infectivity parameter was reduced by more than a factor of 2 compared to the statistics. A differential model of co-infection HIV and tuberculosis spread with multiple drug resistance was developed and its local identifiability was shown.
An analysis of online reputation at integrated resort in Macao—Evidence from the survey of customer online review
Authors: Tang Mengying , Zhang Xiaobin , Wang Jue , Kim Hak-Seon
Published: June 2023

Integrated resorts, an important business card for Macao’s tourism industry, has attracted many tourists and become an important economic pillar. Customer reviews posted on the Internet are an important reflection of the online reputation of integrated resorts and can directly affect performance. Thus, integrated resort operators and destination managers need to develop business strategies by knowing key influencing factors in online reputation of Macao’s integrated resorts. In this study, 13,282 customer reviews were collected from the top five Macao integrated resorts in terms of number of reviews on Google Travel. Through cluster analysis, nighty-nine keywords with the highest frequency were divided into four clusters: “entertainment”, “experience”, “facilities”, and “atmosphere”. The results of factor analysis classified fifteen keywords into four groups: “consumption”, “room service”, “transportation”, and “entertainment”. Finally, the results of the linear regression analysis indicated that “consumption”, “room service”, and “entertainment” had a significant positive effect on online reputation, while “transportation” had a non-significant negative effect. This study enriches the research on the online reputation of integrated resorts by using big data technology and puts forward decision-making suggestions to stakeholders on the key influencing factors in online reputation based on the data analysis results and the findings of related studies.