bluuebunny/crossref_metadata_2025 huggingface dataset:
Association of Psychological Factors with Limb Disability in Patients with Cervical Radiculopathy: Comparison with Carpal Tunnel Syndrome
Authors: Moradi Ali , B.O. Mahla Daliri , Khorasani Hamidreza Mazloum , Olia Neda Daliri Beirak , Azhari Amin , Shakeri Mohammadtaghi
Published: April 2022

Background: Regarding musculoskeletal conditions, patient’s psychological distress, are shown to be associated with higher disability. This study aims to investigate the association of validated scores for depression, anxiety, and pain catastrophizing, with measures of upper limb patient-reported and performance-based disability, in patients with cervical radiculopathy (CR), and compare the obtained results with our similar study on carpal tunnel syndrome (CTS).Methods: In a cross-sectional study, we recruited 92 patients with CR, and investigated their disability level using patient-reported questionnaires (Quick Disabilities of the Arm, Shoulder and Hand (DASH) and pain Likert Scale) and by measuring grip and pinch strength. We also assessed their psychological status with Hospital Anxiety and Depression Scale questionnaire for depression (HADS-D) and anxiety (HADS-A) and also Pain Catastrophizing Scale (PCS) tools. We performed correlational coefficient analysis between disability and psychological scores and regression analysis of dependent variables (Pain, DASH, grip and pinch scores) and independent (psychological) variables. Finally, Z observed value was calculated to compare correlational coefficients between two diseases of CTS and CR.Results: The results of the correlational coefficient analysis indicate that all three HADS-A, HADS-D and PCS scores correlated with DASH score (r = 0.49, 0.37, 0.38 for HADS-A, HADS-D and PCS, respectively; p < 0.001 for all three). HADS-A also significantly correlated with VAS pain score (r = 0.41, P <0.001) and grip strength (r = -0.25, P = 0.016). Linear regression analysis revealed that anxiety has a notable predicting value for DASH and VAS pain scores as well as grip strength. Fisher’s r correlation coefficient to z transformation, revealed that there was no difference between two diseases of CTS and CR in terms of the resulted r coefficients from correlational coefficient analysis between disability and psychological distress.Conclusion: It is concluded that psychological disorders are associated with disability in CR patients, with anxiety also correlating with objective disability parameter of grip strength. Finally, both CTS and CR patients’ disabilities relate to psychological conditions in a similar manner. Level of Evidence: Level IV (cross-sectional study)
Recurrence risk stratification using radiologic-EBV DNA to identify enlarged retropharyngeal lymph nodes of nasopharyngeal carcinoma: a model-histopathologic correlation study
Authors: Mao Minjie , Sheng Hui , Seeruttun Sharvesh Raj , Chi Peidong , Huang Kewei , Liu Wen , Tan Wencheng
Published: April 2022

Background
Accurate assessment of the nature of enlarged retropharyngeal lymph nodes (RLN) of nasopharyngeal carcinoma (NPC) patients after radiotherapy is essential for planning the treatment. This study aimed to develop a non-invasive and effective model for predicting the recurrence of RLN (RRLN) in NPC.
Methods
The data of post-radiotherapy NPC patients (N = 76) with abnormal enlargement of RLN who underwent endonasopharyngeal ultrasound-guided fine-needle aspirations (EPUS-FNA) were examined. They were randomly divided into a discovery (n = 53) and validation (n = 23) cohort. Univariate logistic regression was used to assess the association between variables (magnetic resonance imaging characteristics, EBV DNA) and RRLN. Multiple logistic regression was used to construct a prediction model. The accuracy of the model was assessed by discrimination and calibration, and decision curves were used to assess the clinical reliability of the model to assist decision-making.
Results
Abnormal enhancement, minimum axis diameter (MAD) and EBV-DNA were identified as independent risk factors for RRLN and could stratify NPC patients into three risk groups. The probability of RRLN in the low-, medium- and high-risk groups were 37.5%, 82.4%, and 100%, respectively. The AUC of the final predictive model was 0.882 (95% CI:0.782–0.982) in the discovery cohort and 0.926 (95% CI,0.827–1.000) in the validation cohort, demonstrating good clinical accuracy for predicting the RRLN of NPC patients. The favorable performance of the model was confirmed by the calibration plot and decision curve analysis.
Conclusions
The proposed radiologic and EBV DNA model to predict the RRLN of NPC patients after radiotherapy could be a valuable tool for clinical decision-making.
Prediction of the potential distribution of the predatory mite Neoseiulus californicus (McGregor) in China under current and future climate scenarios
Authors: Chen Lin , Jiang Chunxian , Zhang Xueyan , Song Cancan , Wang Rulin , Wang Xian , Li Qing
Published: April 2022

Neoseiulus californicus is a predatory mite with a wide global distribution that can effectively control a variety of pest mites. In this study, MaxEnt was used to analyse the potential distribution of N. californicus in China and the BCC-CSM2-MR model was used to predict changes in the suitable areas for the mite from 2021-2100 under three climate change scenarios: SSP126, SSP245 and SSP585. The results showed that (1) the average AUC value of the model was over 0.95, which demonstrated an excellent model accuracy. (2) Annual mean temperature (Bio1), precipitation of the coldest quarter (Bio19), and precipitation of the driest quarter (Bio17) were the main climatic factors that affected and controlled the potential distribution of N. californicus, with suitable ranges of 6.97-23.27 °C, 71.36-3924.8 mm, and 41.94-585.08 mm, respectively. (3) The suitable areas for N. californicus were mainly distributed in the southern half of China, with a total suitable area of 226.22× 104 km2 in current. Under the future climate change scenario, compared with the current scenario, lowly and moderately suitable areas of N. californicus increased, while highly suitable areas decreased. Therefore, it may be necessary to cultivate high-temperature resistant strains of N. californicus to adapt to future environmental changes.
Self-cleaning, hydrophilic ZnO and REM oxides doped-ZnO coatings manufactured via sol-gel spin-coating method
Authors: Tański Tomasz , Zaborowska Marta , Jarka Paweł , Woźniak Anna
Published: April 2022

Hydrophilic photocatalytically active ZnO and ZnO thin films doped with Yb2O3 and Eu2O3 with optical transmittance exceeding 76% in the visible light range (λ = 550 nm) were prepared by a combination of sol-gel technique, spin-coating and high temperature thermal treatment at 500 and 600℃. The thin films were tested using advanced research methods, i.e.: morphology and topography and fractures along with approximate thickness values were investigated on scanning electron microscope (SEM), chemical composition was determined using X-ray Energy Dispersive Spectroscopy (X-ray Energy Spectroscopy), topography and roughness were measured on atomic force microscope (AFM), water contact angle values were determined by sitting water droplet method, optical properties of the fabricated materials were investigated using UV/Vis spectrophotometer. The decolorization efficiency of rhodamine B in aqueous solution was analyzed over a period of 190 min, obtaining degradation rates of: 54.7% and 43.1%, for ZnO and ZnO coatings doped with ytterbium oxide and europium oxide, respectively. The roughness of thin hybrid coatings did not exceed 50 nm, ensuring effective absorption of electromagnetic radiation by the layers. The methodology presented by the authors for the fabrication of thin hybrid films characterized by the key properties of self-cleaning coatings can be successfully applied to coatings of photovoltaic panels and architectural glass structures.
Application of diffusion tensor imaging and neurophysiological monitoring in the quantitative and predictive evaluation of spinal cord function
Authors: Cao Yue , Liu Xin-Rui , Song Hong-Mei , Chong Shin-Tai , Cui Yu-He , Huang Qi , Yu Ming-Xin , Bai Yang , Xu Hai-Yang , Zhao Gang
Published: April 2022

Objective: To identify which the combination of diffusion tensor imaging (DTI) and neurophysiological monitoring (NM) is reliable in the quantitative and predictive evaluation of spinal cord function. Methods: Data acquisition was collected in 12 patients who underwent ﻿spinal cord tumor surgery in our hospital. Fractional anisotropy (FA) and apparent diffusion coefficient (ADC) data of the regions of interest (ROIs) on DTI images were obtained. Preoperative NM and intraoperative neurophysiological monitoring (IONM) were performed. Patients were followed up 2 weeks later. European myelopathy score (EMS score) was recorded pre- and post-operatively. Correlation analysis was conducted to evaluate spinal cord function.Results: The average value of ADC in the two ROIs before operation was higher than that in the area without spinal cord compression (P=0.026), while the average value of FA was the opposite (p=0.018). Preoperative FA value significantly decreased in the fiber-interrupted group and the moderate-to-severe-damage group (P<0.05). The preoperative FA value had more significant positive correlation with the postoperative EMS score (R=0.853, P=0), while the preoperative SEP amplitude had more significant positive correlation with the improvement rate (R=0.826, P=0.001). Conclusion: ﻿For spinal cord tumor patients, the combination of preoperative DTI and NM could quantify the postoperative spinal cord function and predict the prognosis more comprehensively. Preoperative FA value is more valuable to reflect the postoperative subjective symptom, while preoperative SEP amplitude is more meaningful to predict the improvement degree of disease.
The protective effect of aspirin-induced temporary threshold shift in an animal model of cisplatin-related ototoxicity
Authors: Tzelnick Sharon , Mizrachi Aviram , Barkan Neta , Shivatzki Shaked , Yosefof Eyal , Hikri Elad , Attias Joseph , Hilly Ohad
Published: April 2022

purpose: The purpose of this study was to evaluate whether induction of temporary threshold shift (TTS) with aspirin prior to cisplatin exposure can prevent or minimize cisplatin detrimental effects on hearing.Methods: We randomly divided BALB mice into three groups: ]1[ cisplatin only, ]2[ aspirin only, and ]3[ combined aspirin/cisplatin. Cisplatin was administered as a single intraperitoneal injection of 14 mg/kg. Aspirin was administered for three weeks via intraperitoneal injection of 200 mg/kg sodium salicylate, twice daily. Air conduction thresholds were recorded using Auditory Brainstem Responses (ABR). Cochleae were harvested and cochlear hair cells were counted using a scanning electron microscope (SEM).Results: Aspirin-induced TTS have reached an average of 30.05±16.9 dB after two weeks. At 60 days, cisplatin-only treated mice experienced an average threshold shifts of 50.7 dB at 4 kHz, 35.16 dB at 8 kHz, 70dB at 16 kHz, 53.1 dB at 32 kHz. All threshold shifts were significantly worse than for cisplatin/aspirin treated mice with TTS of 11.85 dB at 4 kHz, 3.58 dB at 8 kHz, 16.58 dB at 16 kHz, 20.41dB at 32 kHz (p<0.01). Cochlear cell count with SEM has shown reduction in the number of both inner and outer hair cells in the mid-turn in cisplatin treated mice. Conclusion: Aspirin induced TTS can protect from cisplatin-induced ototoxicity. This beneficial effect was demonstrated by auditory thresholds as well as SEM. Larger pre-clinical and clinical studies are still needed to confirm these findings.
Application of three-dimensional reconstruction of renal tumor vessels to guide laparoscopic partial nephrectomy of hilar tumors and non-hilar tumors under zero ischemia
Authors: Xin SONG , Chen JIANG , Dongming LIU , Wei XUE , Yiran HUANG
Published: April 2022

Objective: To investigate the safety and efficacy of three-dimensional reconstruction of renal tumor vessels to guide laparoscopic partial nephrectomy of hilar tumors and non-hilar tumors under zero ischemia. Methods: The clinical data of 82 patients with renal cancer who underwent zero ischemia retroperitoneal laparoscopic partial nephrectomy in the department of urology of our hospital from January 2018 to January 2021 were retrospectively reviewed. The patients were divided into hilar group and non-hilar group. The clinical data of all patients were statistically analyzed by t-test or χ². Results: There was no significantly difference in gender, age, tumor diameter and pathological stage between hilar and non-hilar tumor group.Most of the target vessels in the hilar tumor group were single targets, while most of the target vessels in the non-hilar tumor group were multiple targets (P<0.05). There was no significantly difference between the groups for mean operative time and length of stay. But hilar tumor group had significantly longer operation time (109.3±9.2 vs. 90.3±9.5 min, p<0.001). There was no significant difference in renal GFR and serum creatinine between the two groups. Hilar tumor group had no significantly difference of change of creatinine and GFR at post-operative 6 and 12 months as compared with non-hilar tumor group. There were no bleeding, urinary leakage, infection and other related complications in the two groups after 1 month follow-up. After 12 months of follow-up, there was no tumor recurrence and metastasis in the two groups. Conclusion: The application of three-dimensional renal tumor vascular reconstruction technology can better realize laparoscopic zero ischemia nephron sparing surgery. The target vessels of patients with hilar, single and early renal cancer are easier to find, which is more suitable for three-dimensional renal tumor vascular reconstruction technology to implement laparoscopic zero ischemia nephron sparing surgery.
Landslide hazard zonation assessment in the Southwestern Highlands of Ethiopia, using integrated approaches of GIS and remote sensing techniques
Authors: Reda Talema Moged , ... Tesfaldet Sisay , Anteneh Zeleke Simachew , .... J Muralitharan Jothimania , Bassa Muluken Fanta
Published: April 2022

Landslide is a common environmental problem in southwestern highlands of Ethiopia. Especially highland area of Konta special woreda is mostly vulnerable for landslide hazards. The study was conducted in northern Konta special woreda which includes Ameya, Gowa, Genji and Chida areas. The main objective of this study was to assess landslide hazard zonation through the integration of GIS and remote sensing techniques. In order to identify sensitivity areas for the occurrence of landslide hazard most important influential factors such as elevation, slope, aspect, drainage density, land-use/land-cover and Normalized difference vegetation index (NDVI) were considered. Further, these factors were weighted using analytical hierarch process method based on their influence for landslide hazard. As a result of this study, very low hazard zonation sites are cover about 10.76 km 2 or 1.78% of the total area whereas low and moderate landslide hazard zonation cover about 259.57 km 2 (38.04%) and 241.86 km 2 (40.02%) respectively. In addition, high and very high landslide hazard zonation are cover about 98.09 km 2 (16.23%) and 24.02 km 2 ( 3.98%) of the total area respectively. Hence, most part of the study area falls under risky landslide hazard zonation. Especially, Ameye and Genji towns is found under higher landslide hazard zonation.
Phosphorus recovery from a pilot-scale grate furnace: influencing factors beyond wet chemical leaching conditions
Authors: Boniardi G. , Turolla A. , Fiameni L. , Gelmi E. , Bontempi E. , Canziani R.
Published: April 2022

Phosphorus is a non-renewable resource going to be exhausted in the future. Sewage sludge ash is a promising secondary raw material due to its high phosphorus content. In this work, the distribution of 19 elements in bottom and cyclone ashes from pilot-scale grate furnace have been monitored to determine the suitability for the phosphorus acid extraction. Moreover, the influence of some parameters beyond wet chemical leaching conditions were investigated. Experimental results showed that bottom ash presented lower contamination in comparison to cyclone ash and low co-dissolution of heavy metals (especially Cr, Pb and Ni), while high phosphorus extraction efficiencies (76–86%) were achieved. High Al content in the bottom ash (9.4%) negatively affected the phosphorus extraction efficiency as well as loss on ignition, while the particle size reduction was necessary for ensuring a suitable contact surface. The typology of precipitating agents did not strongly affect the phosphorus precipitation, while pH was the key parameter. At pH 3.5–5, phosphorus precipitation efficiencies higher than 90% were achieved, with a mean phosphorus content in the recovered material equal to 16–17%, comparable to commercial fertilizers. Instead, the co-precipitation of Fe and Al had a detrimental effect on the recovered material, indicating the need for additional treatments.
LncRNA SBF2-AS1: A Budding Star in Various Cancers
Authors: Tan Fangshun , Chen Jinlan , Wang Bei , Du Zhuoying , Mou Jie , Wu Yinxin , Liu Yuling , Zhao Fangnan , Yuan Chengfu
Published: April 2022

Long non-coding RNA (lncRNA) is a new kind of RNA with a length of over 200 nucleotides. Current
frontiers revealed that lncRNAs implicate in various tumor progression, including tumorigenesis, proliferation,
migration, invasion, metastasis, and angiogenesis. Recently discovered long non-coding RNA SETbinding
factor 2 antisense RNA 1 (lncRNA SBF2-AS1), an oncogenic antisense RNA to SBF2, locates at
11p15.1 locus and is 2708 nt long. Accumulating evidence has demonstrated that lncRNA SBF2-AS1 participates
in the progression of the various tumor, including pathogenesis, diagnosis, treatment, and prognosis of
acute myeloid leukemia (AML), breast cancer (BC), cervical cancer (CC), clear cell renal cell carcinoma
(ccRCC), colorectal cancer (CRC), diffuse large B-cell lymphoma (DLBCL), esophageal squamous cell carcinoma
(ESCC), gastric cancer (GC), glioma, glioblastoma (GBM), hepatocellular carcinoma (HCC), lung cancer
(LC), lung adenocarcinoma (LUAD), non-small cell lung cancer (NSCLC), osteosarcoma (OS), pancreatic cancer
(PC), papillary thyroid cancer (PTC), small cell lung cancer (SCLC). Therefore, we summarized the underlying
mechanisms of lncRNA SBF2-AS1 in various cancers to utilize its therapeutic function in target-selective
treatment modalities.
New Trends in Nontransplant Therapy for Acquired Aplastic Anemia
Authors: Ding Shaoxue , Fu Rong
Published: April 2022

Aplastic anemia (AA) is a hematological disease characterized by pancytopenia and hypofunctional
bone marrow hematopoiesis. Patients with AA are treated with either immunosuppressive therapy (IST) using
anti-thymocyte globulin (ATG) and cyclosporine (CsA) or hematopoietic stem cell transplantation (HSCT), if a
matched donor is available. The standard IST regimen for AA patients results in response rates up to 70% and
even higher overall survival. However, primary and secondary failures after IST remain frequent, and to date,
all attempts aiming to overcome this problem have been unfruitful. The nontransplant therapeutic options for
AA have significantly expanded during the last few years. Here, we review the new trends of nontransplant
therapy for AA and summarize the current therapeutic effect of AA.
Liposomes in the Targeted Gene Therapy of Cancer: A Critical Review
Authors: Akkewar Ashish , Mahajan Nilesh , Kharwade Rohini , Gangane Purushottam
Published: April 2022

Cancer immunotherapy has advanced significantly in recent years. Nanocarriers like liposomes
can improve cancer immunotherapy and even stronger immune responses by improving cell
type-specific distribution. Liposomes are lipid bilayer vesicles that are biodegradable and biocompatible
and are often used as smart delivery systems for both hydrophobic and hydrophilic bioactive. Whereas
the idea of employing liposomes for administering drugs has been known since the 1960s, the early
2000s saw continuing technological advances and formulations for drug entrapment and manufacturing.
Modern deterministic studies have tried discovering more about how genetic material is delivered
through liposomes. Liposomes' interactions with cells are still a bit of mystery. Liposome-mediated
transmission of genetic material experiences systemic impediments perlysosomal degradation, endosomal
escape, and nuclear uptake. Controlling the physical architecture and chemical properties of liposome
structures, such as lipid-to-DNA charge, ester bond composition, size, and ligand complexation
structure, is critical for targeting liposomes' success as vehicles for gene delivery. This analysis focuses
on advancements in ligand-targeted liposomes and theranostic (diagnostic) liposomes for cancer diagnosis
and treatment. This review will explore the numerous transgene mechanisms and molecular targets
implicated in cancer cell death and the associated benefits of using liposomal formulations
throughout the years. This sequence of breakthroughs will interest aspiring researchers and the pharmaceutical
industry involved in liposome development.
Alzheimer’s Disease-Related Psychosis: An Overview of Clinical Manifestations,
Pathogenesis, and Current Treatment
Authors: Benmelouka Amira Y. , Ouerdane Yassamine , Outani Oumaima , Alnasser Yusra T. , Alghamdi Badrah S. , Perveen Asma , Ashraf Ghulam Md. , Ebada Mahmoud Ahmed
Published: April 2022

Behavioral and psychotic manifestations, including aggression, delusions, and hallucinations,
are frequent comorbidities in patients with debilitating nervous illnesses such as Alzheimer’s
disease (AD), Amyotrophic Lateral Sclerosis, Multiple Sclerosis, and Parkinson’s disease. ADrelated
psychosis may be linked to a poor disease prognosis, highlighting that early detection and
management are mandatory. The manifestations are variable and may be very heterogeneous, imposing
a real diagnostic issue. Some assessment tools such as BEHAVE-AD, CERAD-BRSD, and the
Psycho-Sensory Hallucinations Scale have been designed to facilitate the diagnosis. The mechanisms
behind neurodegeneration-related psychosis are complex and are not fully understood, imposing a
burden on researchers to find appropriate management modalities. Familial history and some genetic
disturbances may have a determinant role in these delusions and hallucinations in cases with AD.
The loss of neuronal cells, atrophy in some regions of the central nervous, and synaptic dysfunction
may also contribute to these comorbidities. Furthermore, inflammatory disturbances triggered by
pro-inflammatory agents such as interleukins and tumor necrosis factors are stratified among the potential
risk factors for the onset of numerous psychotic symptoms in Alzheimer’s patients. Little is
known about the possible management tools; therefore, it is urgent to conduct well-designed trials to
investigate pharmacological and non-pharmacological interventions that can improve the care process
of these patients. This review summarizes the current findings regarding the AD-related psychosis
symptoms, pathological features, assessment, and management.
The Human Right to Adequate Food in Brazil: A Multidisciplinary
Approach
Authors: Evangelista Alberto Gonçalves , Prestes Raphael Jayson
Published: April 2022

Over the years, especially after the French Revolution and World War II, human
rights have been internalized by several institutions and legislation worldwide, such as the United
Nations (UN). However, in practice, much still needs to be done for the regulations to be applied.
In Brazil, although the right to food is guaranteed in the Federal Constitution, there is still
a wide disparity in per capita food acquisition in the different regions, with greater acquisitions
in the South, Southeast, and Midwest regions and a significant decrease in the North and Northeast
regions. In addition, the use of antibiotics as performance enhancers (or growth promoters)
in animal production can put the population's health at risk, given the antimicrobial resistance to
important drugs used in human medicine. Thus, the objective of this work is to interdisciplinary
defend the good nutrition of Brazilians.
Recent Updates and Technological Developments in Evaluating Cardiac
Syncope in the Emergency Department
Authors: Ojha Utkarsh , Ayathamattam James , Okonkwo Kenneth , Ogunmwonyi Innocent
Published: April 2022

Syncope is a commonly encountered problem in the emergency department (ED), accounting
for approximately 3% of presenting complaints. Clinical assessment of syncope can be
challenging due to the diverse range of conditions that can precipitate the symptom. Annual mortality
for patients presenting with syncope ranges from 0-12%, and if the syncope is secondary to a
cardiac cause, then this figure rises to 18-33%. In ED, it is paramount to accurately identify those
presenting with syncope, especially patients with an underlying cardiac aetiology, initiate appropriate
management, and refer them for further investigations. In 2018, the European Society of
Cardiology (ESC) updated its guidelines with regard to diagnosing and managing patients with
syncope. We highlight recent developments and considerations in various components of the workup,
such as history, physical examination, investigations, risk stratification, and novel biomarkers,
since the establishment of the 2018 ESC guidelines. We further discuss the emerging role of artificial
intelligence in diagnosing cardiac syncope and postulate how wearable technology may transform
evaluating cardiac syncope in ED.
Efficacy of Mesenchymal Stem Cells from Human Exfoliated Deciduous
Teeth and their Derivatives in Inflammatory Diseases Therapy
Authors: Su Junxiang , Ge Xuejun , Jiang Nan , Zhang Ziqian , Wu Xiaowen
Published: April 2022

Mesenchymal stem cells derived from postnatal orofacial tissues can be readily isolated and
possess diverse origins, for example, from surgically removed teeth or gingiva. These cells exhibit stem
cell properties, strong potential for self-renewal, and show multi-lineage differentiation, and they have
therefore been widely employed in stem cell therapy, tissue regeneration, and inflammatory diseases.
Among them, stem cells from human exfoliated deciduous teeth [SHED] and their derivatives have
manifested wide application in the treatment of diseases because of their outstanding advantages—
including convenient access, easy storage, and less immune rejection. Numerous studies have shown that
most diseases are closely associated with inflammation and that inflammatory diseases are extremely
destructive, can lead to necrosis of organ parenchymal cells, and can deposit excessive extracellular matrix
in the tissues. Inflammatory diseases are thus the principal causes of disability and death from many
diseases worldwide. SHED and their derivatives not only exhibit the basic characteristics of stem cells but
also exhibit some special properties of their own, particularly with regard to their great potential in inhibiting
inflammation and tissue regeneration. SHED therapy may provide a new direction for the treatment
of inflammation and corresponding tissue defects. In this review, we critically analyze and summarize the
latest findings on the behaviors and functions of SHED, serum‑free conditioned medium from SHED
[SHED-CM], and extracellular vesicles, especially exosomes, from SHED [SHED-Exos], and discuss
their roles and underlying mechanisms in the control of inflammatory diseases, thus further highlighting
additional functions for SHED and their derivatives in future therapies.
Cryptolepine Targets TOP2A and Inhibits Tumor Cell Proliferation in Breast Cancer Cells -An In vitroandIn silicoStudy
Authors: Mehraj Umar , Qayoom Hina , Shafi Shazia , Farhana Pzd , Asdaq Syed Mohammed Basheeruddin , Mir Manzoor Ahmad
Published: April 2022

Background:

DNA Topoisomerase II Alpha (TOP2A), a protein-coding gene, is central to the replication process and has been found deregulated in several malignancies, including breast cancer. Several therapeutic regimens have been developed and approved for targeting TOP2A and have prolonged the survival of cancer patients. However, due to the inherent nature of the tumor cell to evolve, the earlier positive response turns into a refractory chemoresistance in breast cancer patients.

Objective:

The study’s main objective was to analyze the expression pattern and prognostic significance of TOP2A in breast cancer patients and screen new therapeutic molecules targeting TOP2A.

Methods:

We utilized an integrated bioinformatic approach to analyze the expression pattern, genetic alteration, immune association, and prognostic significance of TOP2A in breast cancer (BC) and screened natural compounds targeting TOP2A, and performed an in-silico and an in vitro analysis.

Results:

Our study showed that TOP2A is highly overexpressed in breast cancer tissues and overexpression of TOP2A correlates with worse overall survival (OS) and relapse-free survival (RFS). Moreover, TOP2A showed a high association with tumor stroma, particularly with myeloid-derived suppressor cells. Also, in silico and in vitro analysis revealed cryptolepine as a promising natural compound targeting TOP2A.

Conclusion:

Cumulatively, this study signifies that TOP2A promotes breast cancer progression, and targeting TOP2A in combination with other therapeutic agents will significantly enhance the response of BC patients to therapy and reduce the development of chemoresistance.
Study of Multi-layered Cobalt Silicide Nanostructured Thin Films Prepared
by Ion Beam Sputtering
Authors: Kumar Anil , Kaur Karamjit
Published: April 2022

Aims:

This work focuses on the different existing techniques for synthesis of nanomaterials,
the selection of potential process for preparation of Co/Si and Co/Si/Co such that material with optimum
characteristics may be obtained.

Background:

The process of synthesis plays a crucial role in physical properties and associated phenomena
acquired by them, and hence is a deciding factor in various potential applications of the materials.

Objective:

The aim of the study was to investigate the properties of multi-layered cobalt silicide
nanostructured thin films prepared by ion beam sputtering.

Method:

The cobalt silicide is selected for synthesis using IBS technique owing to vast scope of its
application in manufacturing microelectronic devices.

Result:

The formation of nanostructured layers has been confirmed through XRD and XRR patterns.

Conclusion:

The role of substrate thickness, interface quality and crystalline structure is very important
in deciding properties of multilayer nano-structured thin films.
The Effect of The Use of Different Types and Levels of Tapioca Flour on The Physical Quality of Rabbit Meatballs
Authors: Widati Aris Sri , Mustakim Mustakim , Widyastuti Eny Sri , Evanuarini Herly , Amertaningtyas Dedes , Apriliyani Mulia Winirsya
Published: April 2022

The purpose of this research was to determine the best type and level of tapioca flour in rabbit meatballs based on pH, WHC, cooking loss, and color. Rabbit meat and tapioca flour were used as research materials. The method used is a laboratory experiment using a completely randomized design with a factorial pattern. Factor A is the type of tapioca flour, namely dragon tapioca flour and special tapioca flour. Factor B is the level of use of tapioca flour, namely 25% and 50%. The pH value, WHC, cooking loss, and color used as the analyzed variable. Data analysis used Analysis of Variance and if there was a significant effect, it was continued with Duncan's Multiple Distance Test or DMRT. The results showed that the treatment using different types and levels of tapioca flour had a highly significant difference effect (P < 0.01) on WHC, cooking loss, L, a*, and b* and had no effect (P>0.05) on rabbit meatball pH. It can be concluded that tapioca special flour with level 25% gives the best results on characteristic of rabbit meatball.
Исследование и разработка безразрядной изоляции проводов космического применения
Authors: Толстиков С.Ю. , Саенко В.С. , Тютнев А.П.
Published: April 2022

The present research aimed to investigate a charging of the cylindrical insulation layer of wires for space applications under the influence of isotropic electron radiation with an electron injection uniform in the volume of the dielectric. An analytical solution of the first-order differential equation resulting from the proposed charging model is obtained. A software has been developed and received state registration that allows for a complete calculation of the physical parameters of space-application wires resistant to electrification effects. The obtained results are proposed to be used for modeling and testing of wires for space applications in order to completely exclude the physical possibility of the occurrence of electrostatic discharges (ESR) of the "insulation-core" type during the operation (of the spacecraft) in orbit during geomagnetic disturbances in the Earth's magnetosphere.
Влияние искровых разрядов на множественные соударения двух стальных шаров в колыбели Ньютона
Authors: Дубинов А.Е. , Голованов В.В. , Любимцева В.А.
Published: April 2022

The spark discharges influence on multiple collisions of two balls in Newton’s cradle was studied experimentally. The single pendulum dynamics without collisions as well as the dynamics of two pendulums with collisions was video-recorded. A non-monotonic oscillations' damping of the pendulums (the so-called beating effect) was observed both in collisions with spark discharges and without them.
The pendulum oscillations' damping was investigated. It was found that collisions between balls increase the damping coefficient, and spark discharges decrease the damping coefficient.
Комплексная диэлектрическая проницаемость и оптические характеристики композитов полипропилен + Na-=SUP=-+-=/SUP=--монтмориллонит
Authors: Годжаев Э.М. , Мамедова Р.Л. , Ахмедова А.М. , Гарибова С.Н.
Published: April 2022

The paper presents the results of studying the frequency dependence of the real and imaginary parts of the dielectric constant of polypropylene modified with Na+ montmorillonite. Using the experimental values of the complex dielectric constant, the optical functions such as the real and imaginary parts of the refractive index, optical conductivity, reflection and absorption coefficients, the characteristic function of the electron energy losses of PP+x vol% Na+ montmorillonite composites have been determined It is shown that on the basis of a high-pressure polymer with the use of Na + montmorillonite as a filler, it is possible to create composite materials with improved physical parameters. To obtain stable electrophysical properties, it is necessary to optimize the composition of the composite material and the volume of the filler. By the method of dielectric spectroscopy in the frequency course, information is obtained not only on the behavior of the complex dielectric constant, but also on the structure of the composite material, which is indispensable for the purposeful regulation of the volumetric content of the filler.
Оптимизация изготовления одномодовых растянутых оптических волокон для когерентной микрооптики
Authors: Лебедев Н.М. , Миньков К.Н. , Шитиков А.Е. , Данилин А.Н. , Красивская М.И. , Лоншаков Е.А. , Горелов И.К. , Дмитриев Н.Ю. , Биленко И.А.
Published: April 2022

Micro- and nanofibers are the universal elements of the optical schemes for solving wide variety of experimental tasks. One usually uses the commercial optical fiber tapering in the burner’s flame to produce such nanofibers. Such tapers are actively used for production of highly sensitive sensors, experiments with the cold atoms and coupling to optical microresonators. The theoretical model of geometrical shape altering during the fiber tapering and heating was adapted in this publication for use in the algorithm with universal adjustment of the tapering modes to get a fiber with the desired set of parameters. One of the innovations was the implementation of the computer vision to control the tapering process. As a result, the nanofibers with the optimal waist diameter of about 700 nm for the radiation wavelength of 1.55 micron were obtained. The optimized methodic of tapering allows the production of the nanofibers with the transmittance of up to 80%. The produced nanofibers were successfully used for coupling to the crystalline whispering gallery mode microresonator. As a result, the optical combs with the spectrum range up to 200 nm were obtained in IR range.
Evaluation of a Collaborative Care Program for Patients With Treatment-Resistant Schizophrenia: Protocol for a Multiple Case Study
Authors: Jongkind Amy , Hendriks Michelle , Grootens Koen , Beekman Aartjan T F , van Meijel Berno
Published: April 2022

Background

Approximately one-third of all patients with schizophrenia are treatment resistant. Worldwide, undertreatment with clozapine and other effective treatment options exist for people with treatment-resistant schizophrenia (TRS). In this respect, it appears that regular health care models do not optimally fit this patient group. The Collaborative Care (CC) model has proven to be effective for patients with severe mental illness, both in primary care and in specialized mental health care facilities. The key principles of the CC model are that both patients and informal caregivers are part of the treatment team, that a structured treatment plan is put in place with planned evaluations by the team, and that the treatment approach is multidisciplinary in nature and uses evidence-based interventions. We developed a tailored CC program for patients with TRS.

Objective

In this paper, we provide an overview of the research design for a potential study that seeks to gain insight into both the process of implementation and the preliminary effects of the CC program for patients with TRS. Moreover, we aim to gain insight into the experiences of professionals, patients, and informal caregivers with the program.

Methods

This study will be underpinned by a multiple case study design (N=20) that uses a mixed methods approach. These case studies will focus on an Early Psychosis Intervention Team and 2 Flexible Assertive Community treatment teams in the Netherlands. Data will be collected from patient records as well as through questionnaires, individual interviews, and focus groups. Patient recruitment commenced from October 2020.

Results

Recruitment of participants commenced from October 2020, with the aim of enrolling 20 patients over 2 years. Data collection will be completed by the end of 2023, and the results will be published once all data are available for reporting.

Conclusions

The research design, framed within the process of developing and testing innovative interventions, is discussed in line with the aims of the study. The limitations in clinical practice and specific consequences of this study are explained.

International Registered Report Identifier (IRRID)

DERR1-10.2196/35336
Morfologi dan Kandungan Kolkisin Biji Gloriosa Superba yang Diperoleh dari Pantai Krakal, Gunung Kidul
Authors: Rahmawati Sri Indah , Widyastuti Yuli , Yunus Ahmad
Published: April 2022

Gloriosa superba merupakan herba merambat yang mempunyai nama lokal Kembang Sungsang. G. superba berkembangbiak secara liar di daerah Pantai Krakal, Gunung Kidul, Yogyakarta. Herba ini bermanfaat sebagai pengobatan tradisional dan pemuliaan tanaman. Populasi tanaman ini sangat melimpah di sekitar Pantai Krakal dan tidak diketahui manfaatnya oleh masyarakat sekitar. Tujuan penelitian ini adalah mengetahui morfologi secara umum G. superba dan mengetahui kadar kolkisin yang terkandung dalam biji G. superba. Pengambilan contoh G. superba dilaksanakan bulan November 2016 di Pantai Krakal dengan mengambil seluruh bagian tanaman untuk pengamatan morfologi tanaman. Analisis kadar kolkisin yang terkandung dalam biji G. superba menggunakan metode KLT-Densitometri. Hasil penelitian ini menyebutkan bahwa morfologi tanaman ini terdiri dari bunga yang berwarna merah dan kuning, daun berwarna hijau meruncing, biji yang dibungkus oleh buah kapsul, umbi berwarna putih dan batang yang merambat panjang hingga ±5 m. Kadar kolkisin yang terkandung dalam ekstrak air biji G. superba sebesar 12,84 µg/µl (± 2,88).
The Growth of Tiwai (Eleutherine Americana L. Merr.) Under Different Forest Tree Stands in Agroforestry System
Authors: Purwanti Noordiana Herry , Taryono Taryono
Published: April 2022

Agroforestry is a method and system of land management involving the simultaneous cultivation of farm crops and trees Land use under forest stands in the community has not been optimal. This research aims to study the growth, yield and qualitatively secondary metabolite content and find the best microclimate based on stand of different forest trees of  Tiwai (Eleutherine americana L. Merr.). The research was carried out at research field of Agrotechnology Innovation Centre at Kalitirto, Berbah, Sleman, Yogyakarta and laboratory of agriculture production, Institute of Agriculture “INTAN” Yogyakarta. Treatments are  combinations of forest tree stand i.e. gaharu, teak, mahogany, and control, and plant spacing factors i.e. 25 x 20 cm and 20 x 20 cm, and arranged in split block design with 3 replications.  Plant height, leaf numbers, bulb weight and productivity were observed and analyzed statistically using analysis of variance approach. The treatment effects are studied by mean comparisons using Duncan Multiple Range Test  with α = 5%. Qualitative data such as flavonoid content were descriptively analyzed. The result showed that there are statistically different growth and yield of Tiwai grown under forest tree stands. Tiwai which was grown under teak and gaharu with density 20 x 20 cm yielded similar productivity with control which is 271 – 331 g/m2 and equal to 578 – 883 kg boulbs/ha. There is different brewed colors from dark red to deep purplish Red. Types of tiwai secondary metabolite were dependent upon tree stands.  At control, and under mahogany and gaharu, more apigenin was observed, whereas  kaempferol and lutenoid were found under teak and gaharu. The tiwai cultivation under tree stands probably provided benefit with the 1.5 B/C ratio in the agroforestry system.
The Estimation of Genetic Parameters of Cucumber Fruit Yield components (Cucumis sativus L.)
Authors: Setyaningastuti Harumi Farah , Taryono Taryono
Published: April 2022

Cucumber is regarded as main vegetable in Indonesian, however its production cannot match the demand and to increase production can be done by increasing diversity and productivity through plant breeding. The estimation of genetic parameters plays an important role in breeding work, therefore the objectives of this study were to obtain the estimated value of the genetic parameters of some cucumber yield components, to determine the important characteristics of cucumber yield components, and to identify cucumber accessions with high potential yield. The study was conducted at AIC UGM, Berbah, Sleman, Yogyakarta. The accessions used were 23 numbers from the AIC UGM collections and 4 controls. The study used a completely randomized design and analyzed with ANOVA. The results showed that the days to ﬁrst harvest, fruit length, fruit weight, fruit diameter, and ﬂesh thickness give high heritability. The number of fruits and potential yield per hectare gives moderate heritability, and seed rendement gives low heritability. Fruit weight, fruit breadth, and ﬂesh thickness were found as the main important characteristics in yield component. Accession number 372 has the earliest ﬁrst harvest date, accession number 329 and 390 have high potential yield/hectare, fruit weight, fruit length, ﬂesh thickness, and fruit breadth.
Robotics Learning at Elementary School: Constructing Abstractions Using Multiple Instruments
Authors: Nogry Sandra , Spach Michel
Published: April 2022

This paper explores the robotics learning process at elementary school using a sociocultural approach. Its focus is on the activity of students aged 6-8 years during robotics learning sessions designed and implemented by two teachers. Drawing on two case studies, this research examines the functions of artefacts and semiotic representations during the learning process. While numerous artefacts are used, this question, well documented in the field of mathematics, is still little studied in the field of educational robotics. Microgenetic analyses highlight the multiple conversions triggered by the artefacts used in constructing the symbolic representations that make up the formal language to be acquired by students when learning how to program a sequence of instruction. The study highlights the embeddedness of the process of abstraction in this field.
ЦИФРОВОЙ СУВЕРЕНИТЕТ НАЧИНАЕТСЯ С ТРАНСПОРТНЫХ СЕТЕЙ СВЯЗИ
Authors: Попов С.
Published: April 2022

В середине марта в Москве состоялась XIII Международная конференция "Transport Networks Russia & CIS: Развитие магистральных сетей связи". Вопреки традиционному англоязычному названию, пожалуй, впервые за ее историю главную партию в событии исполнили российские производители оборудования для транспортных сетей связи. Этой составляющей конференции в первую очередь посвящен настоящий репортаж.
РАЗРАБОТКА МОДЕЛИ РЕЗЕРВИРОВАНИЯ ВОЛС ФРАГМЕНТА СЕТИ СВЯЗИ
Authors: Логин Э. , Довгий С. , Сторожук Н.
Published: April 2022

Предлагается алгоритм процесса моделирования для оптимального формирования дополнительных маршрутов резервирования сети связи, позволяющего обеспечить резервное соединение узлов в случае повреждения
участка ВОЛC. Результатом моделирования является формирование множества вариантов решения по резервированию ВОЛС на тех участках, где надежность
сети связи не удовлетворяет требуемым значениям, а также оценка характеристик всего фрагмента сети связи и его отдельных элементов.
Implementation Paper on Personalized Travel Recommendation by Mining People Attributes
Authors: Deshmukh Miss. Samradni , Ingole Prof. K. R.
Published: April 2022

Abstract: The recommendation system has growth choices in recent years. The recommendation system is existing in many applications which gives online travel information for individual travel package. A new model named travel recommendation using data mining techniques which extracts the features like locations, travel seasons of various landscapes. Thus, it possesses the material of the travel packages and interests of tourists. Further extending E-TRAST model with the tourist-relation-area season topic model includes relationship with tourists. It includes mining significant tourist locations based on the user search trajectories of users on web and also derives a personalized travel algorithm recommendation system using travelogues and users contributed photos with metadata of this photo by comparing existing different technique. To suggest personalized POI sequence, first famous routes are stratified as per the similarity between user package and route package. Keywords: Travel package, recommender systems, cocktail, topic modeling, and collaborative filtering