bluuebunny/crossref_metadata_2025 huggingface dataset:
Tel1 Activation by the MRX Complex Is Sufficient for Telomere Length Regulation but Not for the DNA Damage Response in Saccharomyces cerevisiae
Authors: Keener Rebecca , Connelly Carla J , Greider Carol W
Published: October 2019

Previous models suggested that regulation of telomere length in Saccharomyces cerevisiae by Tel1(ATM) and Mec1(ATR) would parallel the established pathways regulating the DNA damage response. Here, we provide evidence that telomere length regulation differs from the DNA damage response in both the Tel1 and Mec1 pathways. We found that Rad53 mediates a Mec1 telomere length regulation pathway but is dispensable for Tel1 telomere length regulation, whereas in the DNA damage response, Rad53 is regulated by both Mec1 and Tel1. Using epistasis analysis with a Tel1 hypermorphic allele, Tel1-hy909, we found that the MRX complex is not required downstream of Tel1 for telomere elongation but is required downstream of Tel1 for the DNA damage response. Our data suggest that nucleolytic telomere end processing is not a required step for telomerase to elongate telomeres.
Parabolic Nonlinear Second Order Slip Reynolds Equation: Approximation and Existence
Authors: Ait Hadi K.
Published: October 2019

This work studies an initial boundary value problem for nonlinear degenerate parabolic equation issued from a lubrication slip model. Existence of solutions is established through a semi discrete scheme approximation combined with some a priori estimates.
Numerical Solutions for Micropolar Transport Phenomena over a Nonlinear Stretching Sheet
Authors: Bhargava R. , Sharma S. , Takhar H. S. S. , Bég O. A. A. , Bhargava P.
Published: October 2019

We present a numerical study for the steady, coupled, hydrodynamic, heat and mass transfer of an incompressible micropolar fluid flowing over a nonlinear stretching sheet. The governing differential equations are partially decoupled using a similarly transformation and then solved by two numerical techniques – the finite element method and the finite difference method. The dimensionless translational velocity, microrotation (angular velocity), temperature and mass distribution function are computed for the different thermophysical parameters controlling the flow regime, viz the nonlinear (stretching) parameter, b, Grashof number, G and Schmidt number, Sc. All results are shown graphically. Additionally skin friction and Nusselt number, which provide an estimate of the surface shear stress and the rate of cooling of the surface, respectively, are also computed. Excellent agreement is obtained between both numerical methods. The dimensionless translational velocity (f′) for both micropolar and Newtonian fluids is shown to decrease with an increase in nonlinear parameter b. Dimensionless microrotation (angular velocity), g, generally increases with a rise in nonlinear parameter b (in particular in the vicinity of the wall) and decreases with a rise in convective parameter, G. The effects of other parameters on the flow variables are also discussed. The flow regime has significant applications in polymer processing technology and metallurgy.
Dynamical Complexity in Some Ecological Models: Effects of Toxin Production by Phytoplankton
Authors: Upadhyay R. K. K. , Naji R. K. K. , Kumari N.
Published: October 2019

We investigate dynamical complexities in two types of chaotic tri-trophic aquatic food-chain model systems representing a real situation in the marine environment. Phytoplankton produce chemical substances known as toxins to reduce grazing pressure by zooplankton [1]. The role of toxin producing phytoplankton (TPP) on the chaotic behavior in these food chain systems is investigated. Holling type I, II, and III functional response forms are considered to study the interference between phytoplankton and zooplankton populations in the presence of toxic chemical. Our study shows that chaotic dynamics is robust to changes in the rates of toxin release as well as the toxin release functions. The present study also reveals that the rate of toxin production by toxin producing phytoplankton plays an important role in controlling oscillations in the plankton system. The different mortality functions of zooplankton due to toxin producing phytoplankton have significant influence in controlling oscillations, coexistence, survival or extinction of the zooplankton population. Further studies are needed to ascertain if this defence mechanism suppresses chaotic dynamics in model aquatic systems.
A Study of Steady Buoyancy-Driven Dissipative Micropolar Free Convection Heat and Mass Transfer in a Darcian Porous Regime with Chemical Reaction
Authors: Bég O. Anwar Anwar , Bhargava R. , Rawat S. , Takhar H. S. S. , Bég Tasweer A. A.
Published: October 2019

In the present paper we examine the steady double-diffusive free convective heat and mass transfer of a chemically-reacting micropolar fluid flowing through a Darcian porous regime adjacent to a vertical stretching plane. Viscous dissipation effects are included in the energy equation. Assuming incompressible, micro-isotropic fluid behaviour the transport equations are formulated in a two-dimensional coordinate system (x, y) using boundary-layer theory. The influence of the bulk porous medium retardation is modeled as a drag force term in the translational momentum equation. Transformations render the conservation equations into dimensionless form in terms of a single independent variable, η, transverse to the stretching surface. A simplified first order homogenous reaction model is also used to simulate chemical reaction in the flow. Using the finite element method solutions are generated for the angular velocity field, translational velocity field, temperature and species transfer fields. The effects of buoyancy, porous drag and chemical reaction rate are studied. Chemical reaction is shown to decelerate the flow and also micro-rotation values, in particular near the wall. Mass transfer is also decreased with increasing chemical reaction rate. Increasing Darcy number is shown to accelerate the flow. Applications of the study include cooling of electronic circuits, packed-bed chemical reactors and also the near field flows in radioactive waste geo-repositories.
Dependence on Initial Conditions of Attainable Sets of Control Systems with p-Integrable Controls
Authors: Akyar E.
Published: October 2019

Quasi-linear systems governed by p-integrable controls, for 1 < p < ∞ with constraint ‖u(·)‖p ≤ µ0 are considered. Dependence on initial conditions of attainable sets are studied.
Joule Heating Effect on the Coupling of Conduction with Magnetohydrodynamic Free Convection Flow from a Vertical Flat Plate
Authors: Alim M. A. A. , Alam Md. M. M. , Al-Mamun Abdullah
Published: October 2019

The present work describes the effect of magnetohydrodynamic (MHD) natural convection flow along a vertical flat plate with Joule heating and heat conduction. The governing boundary layer equations are first transformed into a non-dimensional form and resulting nonlinear system of partial differential equations are then solved numerically by using the implicit finite difference method with Keller box scheme. The results of the skin friction co-efficient, the surface temperature distribution, the velocity and the temperature profiles over the whole boundary layer are shown graphically for different values of the Prandtl number Pr (Pr = 1.74, 1.00, 0.72, 0.50, 0.10), the magnetic parameter M (M = 1.40, 0.90, 0.50, 0.10) and the Joule heating parameter J (J = 0.90, 0.70, 0.40, 0.20). Numerical values of the skin friction coefficients and surface temperature distributions for different values of Joule heating parameter have been presented in tabular form.
Fuzzy Probabilistic Analysis of Steel Structure Focused on Reliability Design Concept of Eurocodes
Authors: Kala Z.
Published: October 2019

The modern unification of the European standards EUROCODE requires securing a constant quality of metallurgical production in the EU countries. In this paper, experimentally found statistical characteristics of yield stress, ultimate tensile strength and ductility of Czech and Austrian steel are presented. In the probabilistic reliability analysis, the experimentally found yield stress histograms of structural steel S235 of both Czech and Austrian manufacturing processes are considered as basic parameters. The reliability of steel members designed according to EUROCODE 3 is investigated. The objective of the studies is the verification of partial safety factors of load-carrying capacity, and of load action given in the standard EN1990. Differences in failure probabilities of steel members of Czech and Austrian production are studied in connection with the influence of model fuzzy uncertainties in the determination of load action and load-carrying capacity values.
The Effectiveness of Synergistic Enzymatic Reaction with Limited Mediator
Authors: Kulys J. , Dapkūnas Ž.
Published: October 2019

Kinetics of biocatalytical synergistic reactions has been analyzed with special emphasis on stability and reactivity of mediators. The application to the model of kinetic constants taken from the experiments showed that the quasi steady state (QSS) for reduced and oxidized enzyme was achieved in 0.001 s. However, the QSS for the mediator was not established during measurable time. For this reason the kinetics of biocatalytical synergistic reactions was modeled by solving the ordinary differential equations using software package KinFitSim©.
The calculations showed the increase of an apparent life-time of the mediator in the synergistic reaction. The apparent life-time was most affected by reactivity of mediator. The change of the mediator reactivity from 1 M−1s−1 to 105 M−1s−1 increased the apparent life-time from 19 s to 1538 s. This mediator reactivity can be achieved even for strongly endothermic reaction when difference of redox potential of substrate and mediator is 0.35 V. The increase of mediator life-time increased product yield.
Numerical Investigation of Combined Buoyancy and Surface Tension Driven Convection in an Axi-Symmetric Cylindrical Annulus
Authors: Sankar M. , Venkatachalappa M.
Published: October 2019

A numerical study is conducted to understand the effect of surface tension on buoyancy driven convection in a vertical cylindrical annular cavity filled with a low Prandtl number fluid. The inner and outer cylinders are maintained at different uniform temperatures and the horizontal top and bottom walls are thermally insulated. The upper free surface is assumed to remain flat and non-deformable. A finite difference scheme consisting of the Alternating Direction Implicit method and the Successive Line Over Relaxation method is used to solve the vorticity stream function formulation of the problem. Detailed numerical results of heat transfer rate, temperature and velocity fields have been presented for a wide range of physical parameters of the problem. The flow pattern and temperature distribution in the annular cavity are presented by means of contour plots of streamlines and isotherms. The rate of heat transfer is estimated by evaluating the average Nusselt number. Further, the present numerical results are compared with the existing results and are found to be in good agreement.
Asymptotic Stability, Orbital Stability of Hopf-Bifurcating Periodic Solution of a Simple Three-Neuron Artificial Neural Network with Distributed Delay
Authors: Gupta P. D. D. , Majee N. C. C. , Roy A. B. B.
Published: October 2019

A distributed delay model of a class of three-neuron network has been investigated. Sufficient conditions for existence of unique equilibrium, multiple equilibria and their local stability are derived. A closed interval for a parameter of the system is identified in which Hopf-bifurcating periodic solution occurs for each point of such interval. The orbital stability of such bifurcating periodic solution at the extreme points of the interval is ascertained. Lastly global bifurcation aspect of such periodic solutions is studied. The results are illustrated by numerical simulations.
Unsteady Laminar Free Convection from a Vertical Cone with Uniform Surface Heat Flux
Authors: Pullepu Bapuji , Ekambavanan K. , Chamkha A. J. J.
Published: October 2019

Numerical solutions of, unsteady laminar free convection from an incompressible viscous fluid past a vertical cone with uniform surface heat flux is presented in this paper. The dimensionless governing equations of the flow that are unsteady, coupled and non-linear partial differential equations are solved by an efficient, accurate and unconditionally stable finite difference scheme of Crank-Nicolson type. The velocity and temperature fields have been studied for various parameters Prandtl number and semi vertical angle. The local as well as average skin-friction and Nusselt number are also presented and analyzed graphically. The present results are compared with available results in literature and are found to be in good agreement.
Chaotic Dynamics in a Three Species Aquatic Population Model with Holling Type II Functional Response
Authors: Upadhyay R. K. K.
Published: October 2019

A three-trophic model for marine community is proposed and investigated by means of numerical bifurcation analysis. The proposed model based on a modified version of the Leslie-Gower scheme, incorporates mutual interference in all the three populations and generalizes several other known models in the ecological literature. We investigate the dynamical behavior of the model system by considering the Holling type II functional response of toxin liberation process. Bifurcation diagram and two-dimensional parameter scan suggest that chaotic dynamics is robust to variations in toxin production by phytoplankton. Our study suggests that toxic substances released by TPP population may act as bio-control by changing the state of chaos to order. The mutual interference also induces chaos and acts as both stabilizing and destabilizing factors.
Existence Theorems for Some Classes of Boundary Value Problems Involving the P(X)-Laplacian
Authors: Andrei Ionica
Published: October 2019

We prove an alternative for a nonlinear eigenvalue problem involving the p(x)-Laplacian and study a subcritical boundary value problem for the same operator. The theoretical approach is the Mountain Pass Lemma and one of its variants, which is very useful in the study of eigenvalue problems.
Transient Mixed Convection Flow of A Second-Grade Visco-Elastic Fluid over a Vertical Surface
Authors: Damseh R. A. A. , Shatnawi A. S. S. , Chamkha A. J. J. , Duwairi H. M. M.
Published: October 2019

The viscoelastic boundary layer flow and mixed convection heat transfer near a vertical isothermal surface have been examined in this paper. The governing equations are formulated and solved numerically using an explicit finite difference technique. The velocity and temperature profiles, boundary layer thicknesses, Nusselt numbers and the local skin friction coefficients are shown graphically for different values of the viscoelsatic parameter. In general, it is found that the velocity decreases inside the boundary layer as the viscoelsatic parameter is increased and consequently, the local Nusselt number decreases. This is due to higher tensile stresses between viscoelsatic fluid layers which has a retardation effects on the motion of these layers and consequently, on the heat transfer rates for the mixed convection heat transfer problem under investigation. A Comparison with available published results on special cases of the problem shows excellent agreement.
Chaos Synchronization Using Active Control and Backstepping Control: A Comparative Analysis
Authors: Vincent U. E. E.
Published: October 2019

This paper examines the synchronization performance of two widely used chaos synchronization techniques: active control and backstepping control. It is shown that the two methods have excellent performance, with the active control marginally outperforming the backstepping control in terms of transient analysis. However, the complexity of active controllers suggests that the backstepping control would be more attainable in engineering applications.
Density Dependent Predator Death Prevalence Chaos in a Tri-trophic Food Chain Model
Authors: Bandyopadhyay M. , Chatterjee S. , Chakraborty S. , Chattopadhyay J.
Published: October 2019

Ecological systems have all the properties to produce chaotic dynamics. To predict the chaotic behavior in an ecological system and its possible control mechanism is interesting. Aziz-Alaoui [1] considered a tri-trophic food-chain model with modified Leslie-Gower type growth rate for top-predator population and established the chaotic dynamics exhibited by the model system for a certain choice of parameter values. We have modified the said model by incorporating density dependent death rate for predator population. Our mathematical findings reveal the fact that there are two coexisting equilibrium points one of which is a source and the other one is a sink. The positive equilibrium point which is sink is actually globally asymptotically stable under certain parametric conditions. Numerical experiment analysis shows that the model system are capable to produce chaotic dynamics when the rate of intra specific completion is very low and chaotic dynamics disappears for a certain value of the rate of intra specific completion for predator species. Our results suggest that the consideration of density dependent death rate for predator species have the ability to control the chaotic dynamics.
The Method of Prime Costs Determination of the Model Row Goods
Authors: Barashkov A. S. S. , Petrosian D. S. S.
Published: October 2019

The concept of the model row goods is introduced. These are the interchangeable goods differing by quality and price. Cognacs of various vintage years produced on one cognac factory are a typical example of such goods. For the indicated kind of the goods the method of the cost price determination of the goods of competitors is worked out and realized. The initial information for determination is the data on the prices of the goods and sales volumes.
Analysis of a Vaccination Model for Carrier Dependent Infectious Diseases with Environmental Effects
Authors: Naresh Ram , Pandey Surabhi , Misra A. K. K.
Published: October 2019

We have proposed and analyzed a nonlinear mathematical model for the spread of carrier dependent infectious diseases in a population with variable size structure including the role of vaccination. It is assumed that the susceptibles become infected by direct contact with infectives and/or by the carrier population present in the environment. The density of carrier population is assumed to be governed by a generalized logistic model and is dependent on environmental and human factors which are conducive to the growth of carrier population. The model is analyzed using stability theory of differential equations and numerical simulation. We have found a threshold condition, in terms of vaccine induced reproduction number R(φ) which is, if less than one, the disease dies out in the absence of carriers provided the vaccine efficacy is high enough, and otherwise the infection is maintained in the population. The model also exhibits backward bifurcation at R(φ) = 1. It is also shown that the spread of an infectious disease increases as the carrier population density increases. In addition, the constant immigration of susceptibles makes the disease more endemic.
Numerical Approximation of Some Infinite Gaussian Series and Integrals
Authors: Stoncelis M. , Vaičiulis M.
Published: October 2019

The paper deals with numerical computation of the asymptotic variance of the so-called increment ratio (IR) statistic and its modifications. The IR statistic is useful for estimation and hypothesis testing on fractional parameter H ∈ (0, 1) of random process (time series), see Surgailis et al. [1], Bardet and Surgailis [2]. The asymptotic variance of the IR statistic is given by an infinite integral (or infinite series) of 4-dimensional Gaussian integrals which depend on parameter H. Our method can be useful for numerical computation of other similar slowly convergent Gaussian integrals/series. Graphs and tables of approximate values of the variances σp2(H) and σˆp2(H), p = 1, 2 are included.
Hopf Bifurcation Analysis in a Delayed Kaldor-Kalecki Model of Business Cycle
Authors: Kaddar A. , Talibi Alaoui H.
Published: October 2019

In this paper, we analyze the model of business cycle with time delay set forth by A. Krawiec and M. Szydłowski [1]. Our goal in this model is to introduce the time delay into capital stock and gross product in capital accumulation equation. The dynamics are studied in terms of local stability and of the description of the Hopf bifurcation, that is proven to exist as the delay (taken as a parameter of bifurcation) cross some critical value. Additionally we conclude with an application.
Effects of Suction and Blowing on Flow Separation in a Symmetric Sudden Expanded Channel
Authors: Layek G. C. C. , Midya C. , Mukhopadhyay S.
Published: October 2019

A numerical simulation has been carried out to study the laminar flow in a symmetric sudden expanded channel subjected to a uniform blowing/suction speed placed at the lower and upper porous step walls. The governing equations for viscous flow have been solved using finite-difference techniques in pressure-velocity formulation. The results obtained here have been compared with the available experimental and numerical results of similar problems. It is noted that the recirculating region formed near the step walls diminishes in its length for increasing values of blowing speed applied at the porous step walls. For a suitable blowing speed, the recirculation zone disappears completely. The critical Reynolds number for the flow bifurcation (i.e. flow asymmetry) is obtained and it increases with the increase of the blowing speed. The critical Reynolds number for symmetry breaking of the flow decreases with the increasing values of suction speeds. The primary and the secondary recirculating regions formed near the channel walls are controlled using blowing.
The Palliative Use of Intrathecal Baclofen in Niemann-Pick Disease Type C
Authors: Ubeda Tikkanen Ana , Buxton Kristin , Ullrich Christina K. , Stone Scellig SD. , Nimec Donna L.
Published: October 2019

Niemann-Pick disease type C is a rare progressive genetic disorder that leads to the abnormal accumulation of lipids within various tissues of the body, including brain tissue and liver. There is a rapid progression of the disease, resulting in severe disability in only a few years after the first symptoms, and survival is not much longer. Spasticity, dystonia, and chronic pain are common findings that severely impact quality of life in these patients. Analgesic management with traditional pain medications is not always effective, and the risk for secondary effects in medically complex patients is high. Liver function is also a limiting factor in these patients. This is a case report of a boy with advanced Niemann-Pick disease type C with developmental regression, cataplexia, and seizures. His severe spasticity made positioning and care difficult, and intense pain required multiple hospitalizations. He had unsuccessfully trialed multiple drugs. An intrathecal baclofen pump was placed without surgical complications and resulted in positive clinical effects. Baclofen pumps have classically been used for spasticity management in adults and children with nonprogressive diseases such as cerebral palsy or spinal cord injury with relatively long life expectancies. In adults, they have been used in patients with multiple sclerosis; however, use in pediatric neurodegenerative diseases has scarcely been reported. The use of intrathecal baclofen in palliative settings might provide an additional resource to provide comfort and quality of life for children with neurodegenerative diseases not only at end-of-life stages but also earlier on.
Power spectrum and coherence of electroencephalograms of young people with the use of mnemotechnics
Authors: Usenkо Y. , Severynovska О. , Kоfan І. , Dregval І. , Znanetska O.
Published: October 2019

The increase of external information and the need for processing of large information arrays has been leading to the search for mechanisms of thinking in mental activity, as well as new methods of data protection and reproduction. Power spectrum and coherence of electroencephalograms (EEG) during memorizing of foreign words has been analyzed in many ways: in the usual one with the help of mnemotechnics. The research was conducted during the ovarian phase of the cycle of 11 female students aged 18–20. Registration of EEG activity was carried out according to the international system of H. Jasper,"10–20". The process of recollection of associative information led to the decrease in the power spectrum of the EEG in the alpha range in the frontal and temporal loci of the left hemisphere and the prefrontal sections of both hemispheres, in the beta range it was probable only in T6 zone of beta2 range, in the delta range it was in the prefrontal, posterior lower-frontal and posttemporal loci of both hemispheres, in the central, parietal and occipital regions of the left hemisphere, as well as in the anteriofrontal zone of the right hemisphere, in the theta-range – in the prefrontal and posterior lower-frontal regions of both hemispheres and in the posttemporal and occipital loci of the left hemisphere. Synchronization in the delta range is the reflection of the processes of figural information processing and manipulation. With the increase of attention concentration, the synchronization was observed in the theta range in the anteriofrontal and F4–P4 zones. Interhemispheric functional and symmetrical bonds in the alpha and beta ranges indicate the involvement of the corpus callosum in the process of memorizing foreign words, which facilitates their faster, more correct and easier reproduction, especially with the use of associative images. The decrease of power spectrum in the delta and theta ranges showed that less effort was required to reproduce associative information than to mention unsupported images of foreign words. The effective use of the association method is realized by reduction of the power spectrum of the waves in the alpha range in the frontal and temporal loci of the left hemisphere and the prefrontal sections of both hemispheres, which indicates the activation of mental activity in these zones in the processes of maintaining and reproducing associative information.
Influence of staphylococcal Phage SAvB14 on biofilms, formed by Staphylococcus aureus variant bovis
Authors: Horiuk Y. V. , Kukhtyn M. D. , Stravskyy Y. S. , Klymnyuk S. I. , Vergeles K. M. , Horiuk V. V.
Published: October 2019

The use of bacteriophages for the treatment of chronic inflammatory processes has proved to be relevant, especially during isolation of antibiotic-resistant pathogens formed in biofilms. The article presents the results of research on the influence of Phage SAvB14 on young and mature biofilms formed by Staphylococcus aureus variant bovis. In the experiments we used cultures of S. aureus and a specific Phage SAvB14 isolated from the secretion of the mammary gland of cows suffering from chronic mastitis. In the study of the influence of bacteriophage on formed biofilms we determined the optical density of the dye solution that was washed from the biofilm photometrically on a spectrophotometer PE-5400UV (Ecroskhim, Russia) and the number of staphylococcal cells in the biofilm after the action of the bacteriophage on 24-hour and 72-hour biofilms by a ten-fold dilution on beef-extract agar. It was determined that under the influence of the bacteriophage on young 24-hour biofilms of S. aureus var. bovis, the optical density of the dye solution from biofilm increased within 4 hours up to 10% and the number of microbial cells increased by 1.8 times. After 32 hours of bacteriophage action, the optical density of the dye solution decreased on average by 34% compared to the initial density and the number of S. aureus cells in the biofilm decreased by 30 times. This indicates that microbial cells of young biofilms are not subject to complete lysis during the action of even this specific bacteriophage. Degradation of 77.5% of biofilm under the influence of the bacteriophage was observed on mature 72-hour biofilm within 32 hours at 37 °C. At the same time, viable cells of S. aureus were not isolated from the biofilm. This indicates the high lytic activity of the bacteriophage against mature biofilm bacteria and the possibility of its use in chronic staphylococcal infections caused by S. aureus var. bovis. Thus, the obtained data indicate that when mature 72-hour biofilms are exposed to the researched bacteriophage, their degradation is more intense compared with the young 24-hour biofilms, and the amount of destroyed biofilm was on average 2 times higher. This suggests that the use of specific staphylococcal Phage SAvB14 isolated by us for the destruction of biofilm, formed by S. aureus var. bovis, is promising.
Regulation of physiological processes in winter wheat by growth regulators in conditions of powdery mildew infection
Authors: Mamenko Т. P. , Yakymchuk R. A.
Published: October 2019

An important way of regulating the key units of metabolism in the plant organism under the action of stressors is the use of biologically active substances with regulating properties – plant growth regulators. They affect endogenous regulatory systems, altering key metabolic pathways and thus increasing the plant's sustainability and productive potential in adverse environmental conditions. The aim of the research was to establish the possibility of regulation of physiological processes in winter wheat varieties by exogenous treatment of plants with growth regulators of synthetic (salicylic acid) and natural (Emistim C and Biolan) origin to increase their resistance to the phytopathogen Erysiphe graminis DC f. sp. tritici Em. Marchal , the causative agent of powdery mildew. The intensity of the physiological processes in plants was evaluated by the dynamics of the activity of antioxidant enzymes – ascorbate peroxidase and catalase, the release of ethylene and the integrity of the cell membranes. The objects were selected varieties of soft winter wheat, which were grown in controlled growing conditions against the background of infection by powdery mildew. The treatment of plants was carried out using aqueous salicylic acid solutions in the concentration of 10–5 M (experimentally established by us), Emistim C and Biolan (manufacturer Agrobiotech) in the concentration specified by the manufacturer at the rate of 20 mL/ha, when the development of the disease reached 5% of the total natural background of the infection in the plants during the stages of heading-beginning of flowering. Infection of winter wheat with powdery mildew leads to disruption of cell membrane integrity, increased activity of catalase and ascorbate peroxidase in leaves of the susceptible winter wheat variety. The intensification of ethylene release by leaves of the resistant variety was observed, which was caused by the hypersensitive reaction of the hormone to the effect of stress. The use of plant treatment by growth regulators contributes to maintaining the integrity of membrane structures, adaptive changes in the activity of antioxidant enzymes and regulation of the synthesis of the stress hormone ethylene in both winter wheat varieties under stress. Such changes in the physiological processes induced by plant growth regulators are accompanied by the preservation of the grain productivity of winter wheat and the increase of their resistance to the development of the disease.
Influence of Different Implants on the Biomechanical Behavior of a Tooth-Implant Fixed Partial Dentures: A Three-Dimensional Finite Element Analysis
Authors: Lencioni Karina Albino , Noritomi Pedro Yoshito , Macedo Ana Paula , Ribeiro Ricardo Faria , Pereira de Almeida Rossana
Published: October 2019

This study analyzed the biomechanical behavior of rigid and nonrigid tooth-implant supported fixed partial dentures. Different implants were used to observe the load distribution over teeth, implants, and adjacent bone using three-dimensional finite element analysis. A simulation of tooth loss of the first and second right molars was created with an implant placed in the second right molar and a prepared tooth with simulated periodontal ligament (PDL) in the second right premolar. Configurations of two types of implants and their respective abutments—external hexagon (EX) and Morse taper (MT)—were transformed into a 3D format. Metal-ceramic fixed partial dentures were constructed with rigid and nonrigid connections. Mesh generation and data processing were performed on the 3D finite element analysis (FEA) results. Static loading of 50 N (premolar) and 100 N (implant) were applied. When an EX implant was used, with a rigid or nonrigid connection, there was intrusion of the tooth in the distal direction with flexion of the periodontal ligament. Tooth intrusion did not occur when the MT implant was used independent of a rigid or nonrigid connection. The rigid or nonrigid connection resulted in a higher incidence of compressive forces at the cortical bone as well as stress in the abutment/pontic area, regardless of whether EX or MT implants were used. MT implants have a superior biomechanical performance in tooth-implant supported fixed partial dentures. This prevents intrusion of the tooth independent of the connection. Both types of implants studied caused a greater tendency of compressive forces at the crestal area.
Estrategia pedagógica basada en las tecnologias de informacion y comunicación (tic), para la enseñanza de los principios básicos de la convivencia social.
Authors: Espinosa-Urbina Gloria Belén
Published: October 2019

La investigación se plantea con el objetivo general de proponer el uso de las TIC como estrategia pedagógica para laenseñanza de los principios básicos de la convivencia social de los estudiantes de la Institución Educativa Carlos Pérez Escalante de la ciudadde San José de Cúcuta, Norte de Santander, Colombia, convalidando la necesidad de alcanzar mayores niveles de integración y armonía entrelos estudiantes, debido a las problemáticas surgidas con los mismos. El estudio se estructuró en una investigación cuantitativa, de tipodescriptiva, bajo el diseño de campo en la modalidad de proyecto factible. Asimismo, la población y muestra de investigación estuvo formadapor ochenta docentes (80) los cuales atienden a los niños y niñas de educación primaria. La recolección de la información se desarrolló através de la técnica de la encuesta utilizando como instrumento un cuestionario con 22 ítems bajo la escala de Likert con cinco opciones derespuesta: Siempre, casi siempre, algunas veces, casi nunca y nunca. Los resultados de estos instrumentos fueron analizados por medio deestadísticos descriptivos e interpretados. A partir de este análisis se formuló la propuesta correspondiente, así como también, las conclusionesy recomendaciones.
Health-Related Quality of Life in MONARCH 2: Abemaciclib plus Fulvestrant in Hormone Receptor-Positive, HER2-Negative Advanced Breast Cancer After Endocrine Therapy
Authors: Kaufman Peter A. , Toi Masakazu , Neven Patrick , Sohn Joohyuk , Grischke Eva-Maria , Andre Valerie , Stoffregen Clemens , Shekarriz Sarah , Price Gregory L. , Carter Gebra Cuyun , Sledge George W.
Published: October 2019

Background

In the phase III MONARCH 2 study (NCT02107703), abemaciclib plus fulvestrant significantly improved progression-free survival (PFS) versus placebo plus fulvestrant in patients with hormone receptor-positive (HR+), HER2-negative advanced breast cancer (ABC). This study assessed patient-reported pain, global health-related quality of life (HRQoL), functioning, and symptoms.

Materials and Methods

Abemaciclib or placebo (150 p.o. mg twice daily) plus fulvestrant (500 mg, per label) were randomly assigned (2:1). The modified Brief Pain Inventory, Short Form (mBPI-sf); European Organization for Research and Treatment of Cancer (EORTC) QoL Core 30 (QLQ-C30); and Breast Cancer Questionnaire (QLQ-BR23) assessed outcomes. Data were collected at baseline, cycle 2, every two cycles 3–13, thereafter at every three cycles, and 30 days postdiscontinuation. Longitudinal mixed regression and Cox proportional hazards models assessed postbaseline change and time to sustained deterioration (TTSD) by study arm.

Results

On-treatment HRQoL scores were consistently maintained from baseline and similar between arms. Patients in the abemaciclib arm (n = 446) experienced a 4.9-month delay in pain deterioration (mBPI-sf), compared with the control arm (n = 223), and significantly greater TTSD on the mBPI-sf and analgesic use (hazard ratio, 0.76; 95% CI, 0.59–0.98) and QLQ-C30 pain item (hazard ratio, 0.62; 95% CI, 0.48–0.79). TTSD for functioning and most symptoms significantly favored the abemaciclib arm, including fatigue, nausea and vomiting, and cognitive and social functioning. Only diarrhea significantly favored the control arm (hazard ratio, 1.60; 95% CI, 1.20–2.10).

Conclusion

HRQoL was maintained on abemaciclib plus fulvestrant. Alongside superior PFS and manageable safety profile, results support treatment with abemaciclib plus fulvestrant in a population of patients with endocrine-resistant HR+, HER2-negative ABC.
Participation of Foreign Capital in Banking System of the Russian Federation
Authors: Tatarinova Larisa
Published: October 2019

Changes of them political situation in the world, introduction of economic sanctions in regard to the Russian Federation have changed the situation in banking system and have had an impact on the banks activities with foreign participation. The article examines possible variants of foreign capital in the banking system of the Russian Federation, presents the foreign and national practice of the Bank of Russias regulation of foreign investments into the banking sector beginning from 1991 till present. It shows the foreign capital role in own funds (capital), in assets of the Russian Federation banking sphere, in attracting monetary funds of private and legal entities in crediting the real economic sector. It notes that against the general background of decreasing number of the credit organizations of the Russian Federation there is a decrease of the number of the banks with foreign participation, their structural subdivisions. Beginning from 2013, there is a decrease of the foreign capital share. The aggregate charter capital of the national banking system manifests negative trends and other indicators of the banks activities with foreign participation. Beginning from 2014 and up till now, the role of the banks with foreign participation in the banking sector of the Russian Federation is beginning to go down.
Buddhism as a System of Behavioral Rules
Authors: Levchenko Irina
Published: October 2019

The article examines interrelations, mutual influence of Buddhism, Buddhist ethics, religious and legal norms in the process of formation of political and legal systems in historical retrospect and in our days. The author draws attention to the importance of Buddhist religious norms in definition of moral stances, world outlook, value orientations, legal consciousness and rules of behavior. The article brings forth definitions of "Buddhist state", "Buddhist religious community", describes some law features of the modern Buddhist states, as well as the states where Buddhism is officially recognized by the state as a religion. It pays special attention to increasing the Buddhism influence on the state of the legal system not only in the Buddhist states but also in the countries where Buddhist organization play a considerable role and the authority of the Buddhist community (sandhi) increases. The author notes the historical features of the origin and development of the Buddhist community and Buddhist organizations in the Russian Federation. The need for apprehending the Buddhism place in Russias socio-cultural space is connected with the future which is not possible independently of the moral and religious traditions.
Criminological Characteristics and Prevention of Crimes Related to Illicit Trafficking of Special Technical Means for Secret Obtaining of Information (Regional Aspect)
Authors: Usov Evgeny
Published: October 2019

The process of technological development of the society involves the emergence of not only new opportunities, but also new potential threats. Special technical means for secret obtaining information are the devices with unique characteristics that determine their use in law enforcement. At the same time, illegal trafficking of these devices poses a threat to the objects of criminal law protection. The article analyzes the crimes, as provided for by Art. 138.1 of the Criminal Code, committed on the territory of Irkutsk Oblast over the period from 2011 to 2017. It brings forth the criminological features of crimes, as provided for by Art. 138.1 of the Criminal Code of the Russian Federation, committed on the territory of Irkutsk Oblast: it describes the typical methods and time of committing crimes, the peculiarities of the criminals' personality. In addition, this paper offers measures to counteract this type of crime. It gives a criminological characteristics of the crimes connected with illicit trafficking of special technical means for secret receiving of information.
University Communication Channels Transformation in Eurasian Area: Mass Approach or Originality
Authors: Khlebovich Daria
Published: October 2019

The article deals with the processes of university`s communication channels with target audiences transformation. Since universities have a specific role in creating the Eurasian educational system, it is necessary to increase their integration po-tential, especially through the activation of communications through modern channels. Key problems of universities that can be solved through the develop-ment of communication channels are formulated. It is shown that online channels contribute to building a dialogue between the organization and target audiences and generate personal content. The dilemma «a standard decision with an orienta-tion to the experience of others vs a unique decision and a new experience» does not have a single solution. The university site is considered as the most important point of interaction through an online channel. Traditional and unique practices of using the university communication channels are presented. The conclusion is made about the necessity to find innovative and unique solutions that empower the growth of university's competitiveness.
Methodology of Systems Analysis in Sustainable Forest Management
Authors: Rusetskaya Genrietta , Vedernikova Tatyana
Published: October 2019

The article is dedicated to forest systems management in Russia in conditions of increasing discrepancy between decreasing forest areas, degradation of their state and steady growth of need for different functions of forests. Inadequacy of managerial solutions is determined by a variety of problems, among which is lack of systems analysis of the problem of extremely intensive and disorganized timber logging in conditions of inefficient reproduction of trees and low productivity of forests. To switch to sustainable forest management a methodology of sequential analysis of maintenance and reproduction of forest systems has been developed. Complexity growth of highly sophisticated forest systems management, which is characterized by hierarchy and emergence, requires the use of systems analyses of certain subsystems within the structure of forest system at the level of their interaction and relations among them. The forest system structure is represented in the form of large subsystems according to their main objectives: creation of highly efficient and cost effective timber stand, conservation of biological diversity and useful features of forest systems, maintenance of social and economic functions of forests. For overall evaluation of forest systems management, efficiency criteria and indices targeted at final result have been used. At the practical level, these criteria reflect the required changes in the forest system on the whole in simplified form and serve as baseline for intensive techniques of forest systems management. Forests reproduction is determined by a large quantity of natural and anthropogenic factors, among which preparation of soil, quality of seeds, production and planting of seedlings, crop cultivation, felling etc. Each factor should also be considered as a subsystem with corresponding elements and relations among them. For opportune adoption of measures, efficiency evaluation of appropriate activities in the processes of constant dynamics of forest areas is necessary, which allows us to create information basis for predicting short-term and long-term forests reproduction. The influence of each factor can be estimated using orgraphs technique, where the nodes of the graph are the studied indices and the arcs reflect intensity of influence change of one index on the other. A variety of models reflecting the essence and process conditions of the forest system will serve as baseline for building a mathematical model with subsequent switch to digital models.
On the Role of Atomic Engneering Industry in Competitive Recovery of Russia
Authors: Balashova Maria , Naumenko Ilya , Tsvigun Irina
Published: October 2019

According to the internationally recognized ratings of national competitiveness assessment, the relevant global index of Russias economy has been recently stable on the level that does not reflect its real potential. This is also proved by the value of the aggregate designated indicators of the countrys economic development monitoring. The research into the papers that are strategically important for Russias continuous progress indicates the ways the government has chosen for further reforms through integrating an important innovational segment into the countrys economic structure. The article considers one of the ways of increasing the national competitiveness by means of improving the organization of Russian atomic engineering industry. Taking into account the current worldwide trends in this industry, as well as the competitive advantages of the Russian monopolist «Rosatom», its opportunities and threats in the world market, the authors suggest extending the geography of Russian nuclear power technologies usage by selling them to Asia - the fastest growing and developing atomic engineering market in the world.
Possible Focus Areas of Government Regulation of the Real Estate Market
Authors: Bedin Boris
Published: October 2019

The housing problem is relevant for many countries, including Russia. The solution of this problem is impossible without active and meaningful participation by the state. The residential real estate market has specific characteristics that significantly distinguish it from other markets. The article highlights the features of the residential real estate market as an object of government regulation. The author describes specific features of the government as a subject of management of the residential real estate market, substantiates rationale for the active participation of the state in the management of the real estate market, and outlines possible directions of government regulation of the residential real estate market. The author also describes the Russian experience of implementing certain measures in the framework of direct and indirect forms of government regulation of the residential real estate market as well as the results of such events.