bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of Pharyngeal Anaesthesia on Post-Bronchoscopic Coughing: A Prospective, Single Blinded, Multicentre Trial
Authors: Häntschel Maik , Zahn-Paulsen Mariella , Ehab Ahmed , Böckeler Michael , Spengler Werner , Lewis Richard A. , Hautmann Hubert , Hetzel Jürgen
Published: October 2021

Background: Local anaesthesia of the pharynx (LAP) was introduced in the era of rigid bronchoscopy (which was initially a conscious procedure under local anaesthetic), and continued into the era of flexible bronchoscopy (FB) in order to facilitate introduction of the FB. LAP reduces cough and gagging reflex, but its post-procedural effect is unclear. This prospective multicentre trial evaluated the effect of LAP on coughing intensity/time and patient comfort after FB, and the feasibility of FB under propofol sedation alone, without LAP. Material and methods: FB was performed in 74 consecutive patients under sedation with propofol, either alone (35 patients, 47.3%) or with additional LAP (39 patients, 52.7%). A primary endpoint of post-procedural coughing duration in the first 10 min after awakening was evaluated. A secondary endpoint was the cough frequency, quality and development of coughing in the same period during the 10 min post-procedure. Finally, the ease of undertaking the FB and the patient’s tolerance and safety were evaluated from the point of view of the investigator, the assistant technician and the patient. Results: We observed a trend to a shorter cumulative coughing time of 48.6 s in the group without LAP compared to 82.8 s in the group receiving LAP within the first 10 min after the procedure, although this difference was not significant (p = 0.24). There was no significant difference in the cough frequency, quality, peri-procedural complication rate, nor patient tolerance or safety. FB, including any additional procedure, could be performed equally well with or without LAP in both groups. Conclusions: Our study suggests that undertaking FB under deep sedation without LAP does to affect post-procedural cough duration and frequency. However, further prospective randomised controlled trials are needed to further support this finding.
Clinical Efficacy of Ruxolitinib in Patients with Myelofibrosis: A Nationwide Population-Based Study in Korea
Authors: Lee Byung-Hyun , Moon Hyemi , Chae Jae-Eun , Kang Ka-Won , Kim Byung-Soo , Lee Juneyoung , Park Yong
Published: October 2021

Previous studies have reported the survival benefit after ruxolitinib treatment in patients with myelofibrosis (MF). However, population-based data of its efficacy are limited. We analyzed the effects of ruxolitinib in MF patients with data from the Korean National Health Insurance Database. In total, 1199 patients diagnosed with MF from January 2011 to December 2017 were identified, of which 731 were included in this study. Patients who received ruxolitinib (n = 224) were matched with those who did not receive the drug (n = 507) using the 1:1 greedy algorithm. Propensity scores were formulated using five variables: age, sex, previous history of arterial/venous thrombosis, and red blood cell (RBC) or platelet (PLT) transfusion dependence at the time of diagnosis. Cox regression analysis for overall survival (OS) revealed that ruxolitinib treatment (hazard ratio (HR), 0.67; p = 0.017) was significantly related to superior survival. In the multivariable analysis for OS, older age (HR, 1.07; p < 0.001), male sex (HR, 1.94; p = 0.021), and RBC (HR, 3.72; p < 0.001) or PLT (HR, 9.58; p = 0.001) transfusion dependence were significantly associated with poor survival, although type of MF did not significantly affect survival. Considering evidence supporting these results remains weak, further studies on the efficacy of ruxolitinib in other populations are needed.
Spinal Cord Signal Change on Magnetic Resonance Imaging May Predict Worse Clinical In- and Outpatient Outcomes in Patients with Spinal Cord Injury: A Prospective Multicenter Study in 459 Patients
Authors: Jentzsch Thorsten , Cadotte David W. , Wilson Jefferson R. , Jiang Fan , Badhiwala Jetan H. , Akbar Muhammad A. , Rocos Brett , Grossman Robert G. , Aarabi Bizhan , Harrop James S. , Fehlings Michael G.
Published: October 2021

Prognostic factors for clinical outcome after spinal cord (SC) injury (SCI) are limited but important in patient management and education. There is a lack of evidence regarding magnetic resonance imaging (MRI) and clinical outcomes in SCI patients. Therefore, we aimed to investigate whether baseline MRI features predicted the clinical course of the disease. This study is an ancillary to the prospective North American Clinical Trials Network (NACTN) registry. Patients were enrolled from 2005–2017. MRI within 72 h of injury and a minimum follow-up of one year were available for 459 patients. Patients with American Spinal Injury Association impairment scale (AIS) E were excluded. Patients were grouped into those with (n = 354) versus without (n = 105) SC signal change on MRI T2-weighted images. Logistic regression analysis adjusted for commonly known a priori confounders (age and baseline AIS). Main outcomes and measures: The primary outcome was any adverse event. Secondary outcomes were AIS at the baseline and final follow-up, length of hospital stay (LOS), and mortality. A regression model adjusted for age and baseline AIS. Patients with intrinsic SC signal change were younger (46.0 (interquartile range (IQR) 29.0 vs. 50.0 (IQR 20.5) years, p = 0.039). There were no significant differences in the other baseline variables, gender, body mass index, comorbidities, and injury location. There were more adverse events in patients with SC signal change (230 (65.0%) vs. 47 (44.8%), p < 0.001; odds ratio (OR) = 2.09 (95% confidence interval (CI) 1.31–3.35), p = 0.002). The most common adverse event was cardiopulmonary (186 (40.5%)). Patients were less likely to be in the AIS D category with SC signal change at baseline (OR = 0.45 (95% CI 0.28–0.72), p = 0.001) and in the AIS D or E category at the final follow-up (OR = 0.36 (95% CI 0.16–0.82), p = 0.015). The length of stay was longer in patients with SC signal change (13.0 (IQR 17.0) vs. 11.0 (IQR 14.0), p = 0.049). There was no difference between the groups in mortality (11 (3.2%) vs. 4 (3.9%)). MRI SC signal change may predict adverse events and overall LOS in the SCI population. If present, patients are more likely to have a worse baseline clinical presentation (i.e., AIS) and in- or outpatient clinical outcome after one year. Patients with SC signal change may benefit from earlier, more aggressive treatment strategies and need to be educated about an unfavorable prognosis.
Developing a Prediction Model for 7-Year and 10-Year All-Cause Mortality Risk in Type 2 Diabetes Using a Hospital-Based Prospective Cohort Study
Authors: Chiu Sherry Yueh-Hsia , Chen Ying Isabel , Lu Juifen Rachel , Ng Soh-Ching , Chen Chih-Hung
Published: October 2021

Leveraging easily accessible data from hospitals to identify high-risk mortality rates for clinical diabetes care adjustment is a convenient method for the future of precision healthcare. We aimed to develop risk prediction models for all-cause mortality based on 7-year and 10-year follow-ups for type 2 diabetes. A total of Taiwanese subjects aged ≥18 with outpatient data were ascertained during 2007–2013 and followed up to the end of 2016 using a hospital-based prospective cohort. Both traditional model selection with stepwise approach and LASSO method were conducted for parsimonious models’ selection and comparison. Multivariable Cox regression was performed for selected variables, and a time-dependent ROC curve with an integrated AUC and cumulative mortality by risk score levels was employed to evaluate the time-related predictive performance. The prediction model, which was composed of eight influential variables (age, sex, history of cancers, history of hypertension, antihyperlipidemic drug use, HbA1c level, creatinine level, and the LDL /HDL ratio), was the same for the 7-year and 10-year models. Harrell’s C-statistic was 0.7955 and 0.7775, and the integrated AUCs were 0.8136 and 0.8045 for the 7-year and 10-year models, respectively. The predictive performance of the AUCs was consistent with time. Our study developed and validated all-cause mortality prediction models with 7-year and 10-year follow-ups that were composed of the same contributing factors, though the model with 10-year follow-up had slightly greater risk coefficients. Both prediction models were consistent with time.
Retinopathy of Prematurity and Hearing Impairment in Infants Born with Very-Low-Birth-Weight: Analysis of a Korean Neonatal Network Database
Authors: Song Chang Myeon , Ahn Ja-Hye , Hwang Jae Kyoon , Kim Chang-Ryul , Kim Mi Jung , Lee Kyeong Mi , Lee Hyun Ju , Ahn Seong Joon
Published: October 2021

Background: To investigate hearing impairment and its association with retinopathy of prematurity (ROP) among children born with very low birth weight (VLBW, birth weight < 1500 g). Methods: This prospective registry study included 7940 VLBW infants who underwent both ophthalmic (ROP) and hearing screening at the 70 participating centers of the Korean Neonatal Network. Hearing screening was performed using auditory brainstem response and/or automated otoacoustic emission testing. Hearing impairment, defined as a unilateral or bilateral hearing threshold of ≥40 dB on the auditory brainstem response threshold (ABR-T) test, was evaluated and compared between children with and without ROP at the corrected ages of 18 months and 3 years. Results: The frequency of infants who did not undergo hearing screening at near-term ages was higher in the ROP group than in the no-ROP group (18.2% vs. 12.0%, p < 0.001), and the prevalence of hearing impairment at 18 months was higher in the ROP group than in the no-ROP group (3.5% vs. 2.2%, p = 0.043). The prevalence of deafness was higher in children with ROP than those without ROP (0.4% vs. 0.1%, p = 0.049). There were significant differences in hearing impairment among the stages of ROP (p < 0.001). However, multivariate analyses and propensity score matching showed no significant association between ROP and hearing impairment at 18 months and 3 years after adjusting for prematurity-related variables (all p > 0.05). Conclusions: Among infants born with VLBW, hearing impairment was more common in those with ROP than in those without ROP at 18 months of age. However, there was no significant independent association between hearing impairment and ROP.
Incidence and Practice of Early Prone Positioning in Invasively Ventilated COVID-19 Patients—Insights from the PRoVENT-COVID Observational Study
Authors: Stilma Willemke , van Meenen David M. P. , Valk Christel M. A. , de Bruin Hendrik , Paulus Frederique , Serpa Neto Ary , Schultz Marcus J. ,   on behalf of the PRoVENT-COVID Collaborative Group
Published: October 2021

We describe the incidence and practice of prone positioning and determined the association of use of prone positioning with outcomes in invasively ventilated patients with acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019 (COVID-19) in a national, multicenter observational study, performed at 22 intensive care units in the Netherlands. Patients were categorized into 4 groups, based on indication for and actual use of prone positioning. The primary outcome was 28-day mortality. Secondary endpoints were 90-day mortality, and ICU and hospital length of stay. In 734 patients, prone positioning was indicated in 60%—the incidence of prone positioning was higher in patients with an indication than in patients without an indication for prone positioning (77 vs. 48%, p = 0.001). Patients were left in the prone position for median 15.0 (10.5–21.0) hours per full calendar day—the duration was longer in patients with an indication than in patients without an indication for prone positioning (16.0 (11.0–23.0) vs. 14.0 (10.0–19.0) hours, p < 0.001). Ventilator settings and ventilation parameters were not different between the four groups, except for FiO2 which was higher in patients having an indication for and actually receiving prone positioning. Our data showed no difference in mortality at day 28 between the 4 groups (HR no indication, no prone vs. no indication, prone vs. indication, no prone vs. indication, prone: 1.05 (0.76–1.45) vs. 0.88 (0.62–1.26) vs. 1.15 (0.80–1.54) vs. 0.96 (0.73–1.26) (p = 0.08)). Factors associated with the use of prone positioning were ARDS severity and FiO2. The findings of this study are that prone positioning is often used in COVID-19 patients, even in patients that have no indication for this intervention. Sessions of prone positioning lasted long. Use of prone positioning may affect outcomes.
The Development of Electronic Health and Artificial Intelligence in Surgery after the SARS-CoV-2 Pandemic—A Scoping Review
Authors: Taha-Mehlitz Stephanie , Hendie Ahmad , Taha Anas
Published: October 2021

Background: SARS-CoV-2 has significantly transformed the healthcare environment, and it has triggered the development of electronic health and artificial intelligence mechanisms, for instance. In this overview, we concentrated on enhancing the two concepts in surgery after the pandemic, and we examined the factors on a global scale. Objective: The primary goal of this scoping review is to elaborate on how surgeons have used eHealth and AI before; during; and after the current global pandemic. More specifically, this review focuses on the empowerment of the concepts of electronic health and artificial intelligence after the pandemic; which mainly depend on the efforts of countries to advance the notions of surgery. Design: The use of an online search engine was the most applied method. The publication years of all the studies included in the study ranged from 2013 to 2021. Out of the reviewed studies; forty-four qualified for inclusion in the review. Discussion: We evaluated the prevalence of the concepts in different continents such as the United States; Europe; Asia; the Middle East; and Africa. Our research reveals that the success of eHealth and artificial intelligence adoption primarily depends on the efforts of countries to advance the notions in surgery. Conclusions: The study’s primary limitation is insufficient information on eHealth and artificial intelligence concepts; particularly in developing nations. Future research should focus on establishing methods of handling eHealth and AI challenges around confidentiality and data security.
Long-Term Influence of Paraspinal Muscle Quantity in Adolescent Idiopathic Scoliosis Following Deformity Correction by Posterior Approach
Authors: Kim Hong Jin , Yang Jae Hyuk , Chang Dong-Gune , Suk Se-Il , Suh Seung Woo , Nam Yunjin , Kim Sang-Il , Song Kwang-Sup
Published: October 2021

Pedicle screw instrumentation (PSI) through posterior approach has been the mainstay of deformity correction for adolescent idiopathic scoliosis (AIS). However, changes in the quantity of paraspinal muscles after AIS surgery has remained largely unknown. The aim of this study was to investigate long-term follow-up changes in paraspinal muscle volume in AIS surgery via a posterior approach. Forty-two AIS patients who underwent deformity correction by posterior approach were analyzed through a longitudinal assessment of a cross-sectional area (CSA) in paraspinal muscles with a minimum five-year follow-up. The CSA were measured using axial computed tomography images at the level of the upper endplate L4 by manual tracing. The last follow-up CSA ratio of the psoas major muscle (124.5%) was significantly increased compared to the preoperative CSA ratio (122.0%) (p < 0.005). The last follow-up CSA ratio of the multifidus and erector spine muscles significantly decreased compared to the preoperative CSA ratio (all p < 0.005). The CSA ratio of the erector spine muscle was correlated with the CSA ratio of the psoas major (correlation coefficient = 0.546, p < 0.001). Therefore, minimizing the injury to the erector spine muscle is imperative to maintaining psoas major muscle development in AIS surgery by posterior approach.
The Pathophysiology and Management of Hemorrhagic Shock in the Polytrauma Patient
Authors: Fecher Alison , Stimpson Anthony , Ferrigno Lisa , Pohlman Timothy H.
Published: October 2021

The recognition and management of life-threatening hemorrhage in the polytrauma patient poses several challenges to prehospital rescue personnel and hospital providers. First, identification of acute blood loss and the magnitude of lost volume after torso injury may not be readily apparent in the field. Because of the expression of highly effective physiological mechanisms that compensate for a sudden decrease in circulatory volume, a polytrauma patient with a significant blood loss may appear normal during examination by first responders. Consequently, for every polytrauma victim with a significant mechanism of injury we assume substantial blood loss has occurred and life-threatening hemorrhage is progressing until we can prove the contrary. Second, a decision to begin damage control resuscitation (DCR), a costly, highly complex, and potentially dangerous intervention must often be reached with little time and without sufficient clinical information about the intended recipient. Whether to begin DCR in the prehospital phase remains controversial. Furthermore, DCR executed imperfectly has the potential to worsen serious derangements including acidosis, coagulopathy, and profound homeostatic imbalances that DCR is designed to correct. Additionally, transfusion of large amounts of homologous blood during DCR potentially disrupts immune and inflammatory systems, which may induce severe systemic autoinflammatory disease in the aftermath of DCR. Third, controversy remains over the composition of components that are transfused during DCR. For practical reasons, unmatched liquid plasma or freeze-dried plasma is transfused now more commonly than ABO-matched fresh frozen plasma. Low-titer type O whole blood may prove safer than red cell components, although maintaining an inventory of whole blood for possible massive transfusion during DCR creates significant challenges for blood banks. Lastly, as the primary principle of management of life-threatening hemorrhage is surgical or angiographic control of bleeding, DCR must not eclipse these definitive interventions.
Is Saffron Able to Prevent the Dysregulation of Retinal Cytokines Induced by Ocular Hypertension in Mice?
Authors: Fernández-Albarral José A. , Martínez-López Miguel A. , Marco Eva M. , de Hoz Rosa , Martín-Sánchez Beatriz , San Felipe Diego , Salobrar-García Elena , López-Cuenca Inés , Pinazo-Durán María D. , Salazar Juan J. , Ramírez José M. , López-Gallardo Meritxell , Ramírez Ana I.
Published: October 2021

Cytokine- and chemokine-mediated signalling is involved in the neuroinflammatory process that leads to retinal ganglion cell (RGC) damage in glaucoma. Substances with anti-inflammatory properties could decrease these cytokines and chemokines and thus prevent RGC death. The authors of this study analysed the anti-inflammatory effect of a hydrophilic saffron extract standardized to 3% crocin content, focusing on the regulation of cytokine and chemokine production, in a mouse model of unilateral laser-induced ocular hypertension (OHT). We demonstrated that following saffron treatment, most of the concentration of proinflammatory cytokines (IL-1β, IFN-γ, TNF-α, and IL-17), anti-inflammatory cytokines (IL-4 and IL-10), Brain-derived Neurotrophic Factor (BDNF), Vascular Endothelial Growth Factor (VEGF), and fractalkine were unaffected in response to laser-induced OHT in both the OHT eye and its contralateral eye. Only IL-6 levels were significantly increased in the OHT eye one day after laser induction compared with the control group. These results differed from those observed in animals subjected to unilateral OHT and not treated with saffron, where changes in cytokine levels occurred in both eyes. Therefore, saffron extract regulates the production of proinflammatory cytokines, VEGF, and fractalkine induced by increasing intraocular pressure (IOP), protecting the retina from inflammation. These results indicate that saffron could be beneficial in glaucoma by helping to reduce the inflammatory process.
RTA404, an Activator of Nrf2, Activates the Checkpoint Kinases and Induces Apoptosis through Intrinsic Apoptotic Pathway in Malignant Glioma
Authors: Tsai Tai-Hsin , Lieu Ann-Shung , Huang Tzuu-Yuan , Kwan Aij-Lie , Lin Chih-Lung , Hsu Yi-Chiang
Published: October 2021

Background: Malignant glioma (MG) is an aggressive malignant brain tumor. Despite advances in multidisciplinary treatment, overall survival rates remain low. A trifluoroethyl amide derivative of 2-cyano-3-,12-dioxoolean-1,9-dien-28-oic acid (CDDO), CDDO–trifluoroethyl amide (CDDO–TFEA) is a nuclear erythroid 2-related factor 2/antioxidant response element pathway activator. RTA404 is used to inhibit proliferation and induce apoptosis in cancer cells. However, its effect on tumorigenesis in glioma is unclear. Methods: This in vitro study evaluated the effects of RTA404 on MG cells. We treated U87MG cell lines with RTA404 and performed assessments of apoptosis and cell cycle distributions. DNA content and apoptosis induction were subjected to flow cytometry analysis. The mitotic index was assessed based on MPM-2 expression. Protein expression was analyzed through Western blotting. Results: RTA404 significantly inhibited the cell viability and induced cell apoptosis on the U87MG cell line. The Annexin-FITC/PI assay revealed significant changes in the percentage of apoptotic cells. Treatment with RTA404 led to a significant reduction in the U87MG cells’ mitochondrial membrane potential. A significant rise in the percentage of caspase-3 activity was detected in the treated cells. In addition, these results suggest that cells pass the G2 checkpoint without cell cycle arrest by RTA404 treatment in the MPM-2 staining. An analysis of CHK1, CHK2, and p-CHK2 expression suggested that the DNA damage checkpoint system seems also to be activated by RTA404 treatment in established U87MG cells. Therefore, RTA404 may not only activate the DNA damage checkpoint system, it may also exert apoptosis in established U87MG cells. Conclusions: RTA404 inhibits the cell viability of gliomas and induces cancer cell apoptosis through intrinsic apoptotic pathway in Malignant glioma. In addition, the DNA damage checkpoint system seems also to be activated by RTA404. Taken together, RTA404 activated the DNA damage checkpoint system and induced apoptosis through intrinsic apoptotic pathways in established U87MG cells.
Femoral µCT Analysis, Mechanical Testing and Immunolocalization of Bone Proteins in β-Hydroxy β-Methylbutyrate (HMB) Supplemented Spiny Mouse in a Model of Pregnancy and Lactation-Associated Osteoporosis
Authors: Tomaszewska Ewa , Muszyński Siemowit , Donaldson Janine , Dobrowolski Piotr , Chand Deepesh K. P. , Tomczyk-Warunek Agnieszka , Hułas-Stasiak Monika , Puzio Iwona , Lamorski Krzysztof , Sławiński Cezary , Jabłoński Mirosław , Blicharski Tomasz
Published: October 2021

A metabolite of leucine, ß-hydroxy-ß-methylbutyrate (HMB), used as a dietary supplement effects muscle tissue gain and bone tissue quality. Since there are no studies on the effects of HMB during pregnancy yet, the aim of the current study was to determine the effects of HMB supplementation during pregnancy on osteoporotic bone quality postpartum and post-lactation using spiny mice (Acomys cahirinus) as the animal models. The six-month-old dams were divided into four groups: pregnant and lactating controls, and pregnant and lactating HMB-treated (during the second trimester of pregnancy) females. The intensity of the immunoreaction of osteocalcin (OC), osteoprotegerin (OPG), bone morphogenetic protein 2 (BMP-2), tissue inhibitor of metalloproteinases 2 (TIMP-2), matrix metalloproteinase 8 and 13 (MMP-8 and MMP-13) and proteins involved in bone turnover, was measured in femoral trabecular and compact bone, as well as in the hyaline and epiphyseal cartilage of the femora. The analysis of the trabecular bone microarchitecture showed that the administration of HMB to pregnant females, by influencing the proteins responsible for bone cell activity and collagen remodeling, can provide protection from bone loss. Based on the results of the current study it can be assumed that HMB administration to pregnant females has a more positive impact on trabecular than compact bone.
Flexural Property of a Composite Biomaterial in Three Applications
Authors: Irie Masao , Maruo Yukinori , Nishigawa Goro , Matsumoto Takuya
Published: October 2021

Resin composite is widely used in the dental field in clinics as a biomaterial. For example, it has been used as a composite material, a type of biomaterial, to repair caries and restore masticatory function, and as a luting agent to adhere the restoration to the tooth substrate. In order to demonstrate its function, we have measured the mechanical strength. From such basic research, we explain the potential of a dental material through the measurement of flexural strength and modulus of elasticity. In this research, we introduce commercial products that are actually used as composite materials suitable for tooth substrate and provide readers with their properties based on flexural strength and modulus of elasticity. In clinical performance, it might be advisable to delay polishing when a composite material is used for a luting material, a filling material and a core build-up material, as the flexural strength and the flexural modulus of elasticity were improved after 1 day of storage, and flexural strength and characteristics are considered as important mechanical properties of oral biomaterials.
Recent Advances in Strain-Hardening UHPC with Synthetic Fibers
Authors: Dai Jian-Guo , Huang Bo-Tao , Shah Surendra P.
Published: October 2021

This paper summarizes recent advances in strain-hardening ultra-high-performance concretes (UHPC) with synthetic fibers, with emphasis on their tensile properties. The composites described here usually contain about 2.0% high-density polyethylene (PE) fibers. Compared to UHPC with steel fibers, strain-hardening UHPC with synthetic fibers generally show a higher tensile ductility, lower modulus in the cracked state, and relatively lower compressive strength. The tensile strain capacity of strain-hardening UHPC with synthetic fibers increases with increasing tensile strength. The f’cftεt/w index (compressive strength × tensile strength × tensile strain capacity/tensile crack width) is used to compare the overall performance of strain-hardening UHPC. Moreover, a probabilistic approach is applied to model the crack width distributions of strain-hardening UHPC, and estimate the critical tensile strain in practical applications, given a specific crack width limit and cumulative probability. Recent development on strain-hardening UHPC with the use of seawater, sea-sand and PE fibers are also presented.
Flexible Krylov Methods for Edge Enhancement in Imaging
Authors: Gazzola Silvia , Scott Sebastian James , Spence Alastair
Published: October 2021

Many successful variational regularization methods employed to solve linear inverse problems in imaging applications (such as image deblurring, image inpainting, and computed tomography) aim at enhancing edges in the solution, and often involve non-smooth regularization terms (e.g., total variation). Such regularization methods can be treated as iteratively reweighted least squares problems (IRLS), which are usually solved by the repeated application of a Krylov projection method. This approach gives rise to an inner–outer iterative scheme where the outer iterations update the weights and the inner iterations solve a least squares problem with fixed weights. Recently, flexible or generalized Krylov solvers, which avoid inner–outer iterations by incorporating iteration-dependent weights within a single approximation subspace for the solution, have been devised to efficiently handle IRLS problems. Indeed, substantial computational savings are generally possible by avoiding the repeated application of a traditional Krylov solver. This paper aims to extend the available flexible Krylov algorithms in order to handle a variety of edge-enhancing regularization terms, with computationally convenient adaptive regularization parameter choice. In order to tackle both square and rectangular linear systems, flexible Krylov methods based on the so-called flexible Golub–Kahan decomposition are considered. Some theoretical results are presented (including a convergence proof) and numerical comparisons with other edge-enhancing solvers show that the new methods compute solutions of similar or better quality, with increased speedup.
A Review of Modern Thermal Imaging Sensor Technology and Applications for Autonomous Aerial Navigation
Authors: Nguyen Tran Xuan Bach , Rosser Kent , Chahl Javaan
Published: October 2021

Limited navigation capabilities of many current robots and UAVs restricts their applications in GPS denied areas. Large aircraft with complex navigation systems rely on a variety of sensors including radio frequency aids and high performance inertial systems rendering them somewhat resistant to GPS denial. The rapid development of computer vision has seen cameras incorporated into small drones. Vision-based systems, consisting of one or more cameras, could arguably satisfy both size and weight constraints faced by UAVs. A new generation of thermal sensors is available that are lighter, smaller and widely available. Thermal sensors are a solution to enable navigation in difficult environments, including in low-light, dust or smoke. The purpose of this paper is to present a comprehensive literature review of thermal sensors integrated into navigation systems. Furthermore, the physics and characteristics of thermal sensors will also be presented to provide insight into challenges when integrating thermal sensors in place of conventional visual spectrum sensors.
A Hybrid Robust Image Watermarking Method Based on DWT-DCT and SIFT for Copyright Protection
Authors: Hamidi Mohamed , El Haziti Mohamed , Cherifi Hocine , El Hassouni Mohammed
Published: October 2021

In this paper, a robust hybrid watermarking method based on discrete wavelet transform (DWT), discrete cosine transform (DCT), and scale-invariant feature transformation (SIFT) is proposed. Indeed, it is of prime interest to develop robust feature-based image watermarking schemes to withstand both image processing attacks and geometric distortions while preserving good imperceptibility. To this end, a robust watermark is embedded in the DWT-DCT domain to withstand image processing manipulations, while SIFT is used to protect the watermark from geometric attacks. First, the watermark is embedded in the middle band of the discrete cosine transform (DCT) coefficients of the HL1 band of the discrete wavelet transform (DWT). Then, the SIFT feature points are registered to be used in the extraction process to correct the geometric transformations. Extensive experiments have been conducted to assess the effectiveness of the proposed scheme. The results demonstrate its high robustness against standard image processing attacks and geometric manipulations while preserving a high imperceptibility. Furthermore, it compares favorably with alternative methods.
Influence of SST in Low Latitudes on the Arctic Warming and Sea Ice
Authors: Alekseev Genrikh V. , Glok Natalia I. , Vyazilova Anastasia E. , Kharlanenkova Natalia E. , Kulakov Mikhail Yu.
Published: October 2021

Global climate models, focused on projecting anthropogenic warming, have not detected an increase in sea surface temperature (SST) at low latitudes comparable to the observed one. This appears to be one reason for the discrepancy between the model estimates of warming and reduction of the sea ice extent in the Arctic and the observed changes in the climate system. In previous studies, it was shown that short-term manifestations of the impact of low latitudes on the Arctic climate were identified in 2–3 weeks as a result of strengthening of atmospheric circulation patterns. In this paper, for the first time, a climatic relationship was established among an increase in SST, air temperature, and water vapor content at low latitudes, and a decrease in sea ice extent in the Arctic. ECMWF Re-Analysis data (ERA-Interim, ERA5), Hadley Centre Sea Ice and Sea Surface Temperature data set (HadISST), sea ice archives of the World Centers NSIDC (USA), and Arctic and Antarctic Research Institute (Russia), observations of water temperature in the Kola section (33°30’ E), calculated sea ice parameters using the Arctic and Antarctic Research Institute coupled ice-ocean circulation model (AARI–IOCM). Methods of multivariate correlation analysis, calculating spectra and coherence, and creating correlation graphs were used to obtain the results. For the first time, estimates of the effect of heat transport from low to high latitudes on climate change and sea ice extent in the Arctic over the past 40 years have been obtained, explaining a significant part of their variability. The increase in heat transport is affected by an increase in SST at low latitudes, where a significant part of the solar heat is accumulated. Due to the increase in SST, the amount of heat transported by the ocean and the atmosphere from low latitudes to the Arctic increases, leading to an increase in the air temperature, water vapor content, downward longwave radiation at high latitudes, and a decrease in the thickness and extent of winter sea ice. Potential topics include, but are not limited to: the role of heat and moisture transport in the Arctic warming, effect of SST at low latitudes on transports, linkage of warming in low latitudes and in shrinking of the Arctic sea ice.
Monitoring and Forecasting the Ocean State and Biogeochemical Processes in the Black Sea: Recent Developments in the Copernicus Marine Service
Authors: Ciliberti Stefania A. , Grégoire Marilaure , Staneva Joanna , Palazov Atanas , Coppini Giovanni , Lecci Rita , Peneva Elisaveta , Matreata Marius , Marinova Veselka , Masina Simona , Pinardi Nadia , Jansen Eric , Lima Leonardo , Aydoğdu Ali , Creti’ Sergio , Stefanizzi Laura , Azevedo Diana , Causio Salvatore , Vandenbulcke Luc , Capet Arthur , Meulders Catherine , Ivanov Evgeny , Behrens Arno , Ricker Marcel , Gayer Gerhard , Palermo Francesco , Ilicak Mehmet , Gunduz Murat , Valcheva Nadezhda , Agostini Paola
Published: October 2021

The Black Sea Monitoring and Forecasting Center (BS-MFC) is the European reference service for the provision of ocean analyses, forecasts, and reanalyses in the Black Sea basin. It is part of the Copernicus Marine Environment and Monitoring Service (CMEMS) and ensures a high level of efficiency in terms of operations, science, and technology for predictions and the monitoring of physical and biogeochemical processes in the Black Sea. The operational BS-MFC framework is based on state-of-the-art numerical models for hydrodynamics, biogeochemistry, and waves; analysis, forecast, and reanalysis are provided on a spatial grid with about 3 km of horizontal resolution that covers the whole Black Sea basin (the Azov Sea is not included). The scientific assessment of BS-MFC products is performed by implementing a product quality dashboard that provides pre-qualification and operational model skills according to GODAE/OceanPredict standards. Novel interfaces based on high-resolution models are part of the scientific development plan to ensure a strong connection with the nearest seas from a modelling point of view, in particular with the Mediterranean Sea. To improve forecasting skills, dedicated online coupled systems are being developed, which involve physics, biogeochemistry, and waves together with the atmosphere and, in the future, with ensemble forecasting methodologies and river-ocean interfaces.
The Making of a Gravel Beach (Cavo, Elba Island, Italy)
Authors: Cinelli Irene , Anfuso Giorgio , Bartoletti Enrico , Rossi Lorenzo , Pranzini Enzo
Published: October 2021

This paper presents the history and evolution of the different projects carried out from 1999 to 2008 at Cavo beach in the Elba Island, Italy. The village of Cavo almost completely lost its beach in the 1970s due to the reduction of sedimentary input, and the backing coastal road was defended by a revetment and two detached breakwaters. Such severe erosion processes continued in the following years and impeded any possibility of beach tourist development. In 1999, a project based on the removal of existing breakwaters and beach nourishment works based on the use of gravel as borrow sediment and the construction of two short groins to maintain nourished sediment, raised environmental concern and did not find the approval of the stakeholders. They were worried about the characteristics of the sediments, i.e., waste materials from iron mining rich in red silt and clay. Such sediment fractions made the sea red during the nourishment and deposited on the Posidonia oceanica meadow in front of the beach, with a potential environmental impact. Furthermore, they cemented the gravel fraction forming a beach rock. Between 2006 and 2008, these materials were covered with better quality gravel, extending and raising the beach profile, which required the elevation and lengthening of the two existing groins. Beach evolution monitoring following the second project, based on morphological and sedimentological data acquired before, during and after the works, demonstrated the great stability of the newly created beach. The wider beach has allowed the construction of a promenade and the positioning, in summer, of small structures useful for seaside tourism, increasing the appeal of this village. Data presented in this paper shows an interesting study case, since few examples exist in international literature regarding gravel nourishment projects monitoring and evolution.
Sedimentary Environmental Evolution of the Western Taiwan Shoal Area since the Late Pleistocene
Authors: He Chipeng , Sha Longbin , Zhao Dongbo , Dai Lu , Li Zheng , Tang Jiabing , Li Xianfu , Li Dongling
Published: October 2021

A new pollen analysis and major and trace element contents were conducted on a 40 m long gravity core recovered from the Taiwan Shoal (sand ridges), south of the Taiwan Strait, beginning in the Late Pleistocene. The changes in the pollen assemblage and concentration represent the climate change around the Taiwan Shoal and the strength of the Zhe-Min Coastal Current, whereas variations in major and trace element contents can imply the source of the sediments in the Taiwan Shoal, which are correlated with the rise or fall of the sea level with increased marine dinoflagellate cysts. The interval of 40–30 m was characterized by high pollen and spore concentrations, and evergreen Quercus was dominant taxon, which indicates a warm sedimentary environment, and the surrounding area of the Taiwan Shoal were covered by a tropical and subtropical broad-leaved forest. There were no pollen and spores from 30–24 m, which indicates a strong hydrodynamic sedimentary environment, and most of the Taiwan Shoal might have been experience subaerial exposure. The interval of 24–17 m was characterized by the reappearance of pollen and spores, as well as marine dinoflagellate cysts and foraminifera, suggesting the climate was warm and wet in the study area and an apparent marine sedimentary environment with relatively high sea level. Deciduous Quercus dominated the interval of 17–12 m, which indicated that the climate was relatively cool, corresponding to the end of Marine isotope stages3 (MIS3) to the Last Glacial Maximum accompanied by weathering and denudation. Above 12 m, the low pollen concentration with increased marine dinoflagellate cysts and foraminifera abundance suggested a marine sedimentary environment in the Taiwan Shoal. The high concentrations in Pinus corresponds to Holocene high sea level.
Laboratory Study of Integrated Wet-Towing of a Triple-Bucket Jacket Foundation for Far-Offshore Applications
Authors: Yan Chaojun , Wang Haijun , Guo Yaohua , Wang Zhen , Liu Xiao
Published: October 2021

As a form of clean and low-carbon green energy, offshore wind power occupies an important position in the global energy structure. With the rapid development of the wind power industry, wind power projects gradually develop from offshore to far-offshore sea areas. The multi-bucket jacket foundation is a considerable foundation type for far off-shore projects, but high installation costs involving ship transportation with parted components and field installation has significantly hindered its wide application. In this study, based on a 6.7-MW triple-bucket jacket foundation (TBJF) project of a deep-sea wind farm in China, a new integrated wet-towing method of “jacket + triple-bucket foundation” composite structure was proposed, which is suitable for far long-distance transportation of far-offshore applications. The static-model test of both self-stability and wet-towing stability was conducted. Based on the test and the numerical results, the natural period of the foundation for different draft depths in hydrostatic water and the stability for different eccentric loads were first evaluated. Then, the effects of different wet-towing modes and sea conditions on the stability of the TBJF were investigated. Finally, the optimal wet-towing mode and applicable sea conditions for the TBJF structure were proposed.
Role of Protein Glycosylation in Interactions of Medically Relevant Fungi with the Host
Authors: Gómez-Gaviria Manuela , Vargas-Macías Ana P. , García-Carnero Laura C. , Martínez-Duncker Iván , Mora-Montes Héctor M.
Published: October 2021

Protein glycosylation is a highly conserved post-translational modification among organisms. It plays fundamental roles in many biological processes, ranging from protein trafficking and cell adhesion to host–pathogen interactions. According to the amino acid side chain atoms to which glycans are linked, protein glycosylation can be divided into two major categories: N-glycosylation and O-glycosylation. However, there are other types of modifications such as the addition of GPI to the C-terminal end of the protein. Besides the importance of glycoproteins in biological functions, they are a major component of the fungal cell wall and plasma membrane and contribute to pathogenicity, virulence, and recognition by the host immunity. Given that this structure is absent in host mammalian cells, it stands as an attractive target for developing selective compounds for the treatment of fungal infections. This review focuses on describing the relationship between protein glycosylation and the host–immune interaction in medically relevant fungal species.
Morphological and Phylogenetic Appraisal of Novel and Extant Taxa of Stictidaceae from Northern Thailand
Authors: Wei De-Ping , Wanasinghe Dhanushka N. , Gentekaki Eleni , Thiyagaraja Vinodhini , Lumyong Saisamorn , Hyde Kevin D.
Published: October 2021

Stictidaceae comprises taxa with diverse lifestyles. Many species in this family are drought resistant and important for studying fungal adaptation and evolution. Stictidaceae comprises 32 genera, but many of them have been neglected for decades due to the lack of field collections and molecular data. In this study, we introduce a new species Fitzroyomyces hyaloseptisporus and a new combination Fitzroyomycespandanicola. We also provide additional morphological and molecular data for Ostropomyces pruinosellus and O. thailandicus based on new collections isolated from an unidentified woody dicotyledonous host in Chiang Rai, Thailand. Taxonomic conclusions are made with the aid of morphological evidence and phylogenetic analysis of combined LSU, ITS and mtSSU sequence data. Characteristics such as the shape and septation of ascospores and conidia as well as lifestyles among genera of Stictidaceae are discussed.
COVID-19-Associated Invasive Pulmonary Aspergillosis in the Intensive Care Unit: A Case Series in a Portuguese Hospital
Authors: Ranhel David , Ribeiro Ana , Batista Judite , Pessanha Maria , Cristovam Elisabete , Duarte Ana , Dias Ana , Coelho Luís , Monteiro Filipa , Freire Pedro , Veríssimo Cristina , Sabino Raquel , Toscano Cristina
Published: October 2021

Invasive pulmonary aspergillosis (IPA) has become a recognizable complication in coronavirus disease 2019 (COVID-19) patients admitted to intensive care units (ICUs). Alveolar damage in the context of acute respiratory distress syndrome (ARDS) appears to be the culprit in facilitating fungal invasion in COVID-19 patients, leading to a COVID-19-associated pulmonary aspergillosis (CAPA) phenomenon. From November 2020 to 15 February 2021, 248 COVID-19 patients were admitted to our ICUs, of whom ten patients (4% incidence) were classified as either probable (six) or possible (four) CAPA cases. Seven patients had positive cultural results: Aspergillus fumigatus sensu stricto (five), A. terreus sensu stricto (one), and A. welwitschiae (one). Five patients had positive bronchoalveolar lavage (BAL) and galactomannan (GM), and two patients had both positive cultural and GM criteria. All but two patients received voriconazole. Mortality rate was 30%. Strict interpretation of classic IPA definition would have resulted in eight overlooked CAPA cases. Broader diagnostic criteria are essential in this context, even though differentiation between Aspergillus colonization and invasive disease might be more challenging. Herein, we aim to raise awareness of CAPA in view of its potential detrimental outcome, emphasizing the relevance of a low threshold for screening and early antifungal treatment in ARDS patients.
Experience and Perceptions of a Family Health History Risk Assessment Tool among Multi-Ethnic Asian Breast Cancer Patients
Authors: Yoon Sungwon , Goh Hendra , Fung Si , Tang Shihui , Matchar David , Ginsburg Geoffrey , Orlando Lori , Ngeow Joanne , Wu Rebekah
Published: October 2021

A family health history-based risk assessment is particularly valuable for guiding cancer screening and treatment strategies, yet an optimal implementation depends upon end-users’ values and needs. This is not only true prior to disease development, but also for those already affected. The aim of this study is to explore perceptions of the value of knowing one’s family health history (FHH)-based risk, experience using a patient-facing FHH tool and the potential of the tool for wider implementation. Twenty multi-ethnic Asian patients undergoing breast cancer treatment in Singapore completed an FHH-based risk assessment. Semi-structured one-on-one interviews were conducted and data were thematically analyzed. All participants were female and slightly more than half were Chinese. The acceptance and usage of an FHH risk assessment tool for cancers and its broader implementation was affected by a perceived importance of personal control over early detection, patient concerns of anxiety for themselves and their families due to risk results, concerns for genetic discrimination, adequacy of follow-up care plans and Asian cultural beliefs toward disease and dying. This study uniquely sheds light on the factors affecting Asian breast cancer patients’ perceptions about undergoing an FHH-based risk assessment, which should inform steps for a broader implementation in Asian healthcare systems.