bluuebunny/crossref_metadata_2025 huggingface dataset:
Using Piezosurgery in Anterior Cervical Discectomy and Fusion to Treat Complex Cervical Spondylotic Myelopathy Is Safe and Effective
Authors: Li Yu-Wei , Chen Hao-Jie , Zhao Shi-Xin , Li Xiu-Zhi , Wang Hai-Jiao , Zhou Peng , Cui Wei , Xiao Wei , Li Fan , Hu Bingtao
Published: December 2023

Objective. To investigate the safety and efficacy of piezosurgery in anterior cervical discectomy and fusion (ACDF) for cervical spondylotic myelopathy (CSM). Methods. 47 patients with complex CSM (cCSM) underwent ACDF surgery from 2014 to 2017. Among these patients, 26 underwent ACDF using piezosurgery (group A) and 21 underwent ACDF by using traditional tools such as high-speed air drill, bone curette, and Kerrison bone punch (group B). Average surgical time, intraoperative blood loss, surgical complications, preoperative and postoperative Japanese Orthopaedic Association (JOA) scores, and improvement rate were measured. Results. Average surgical time and intraoperative blood loss were significantly lower in group A than those in group B (P<0.01). The incidences of surgical complications were 3.8% and 23.8% in the A and B groups (P<0.05), respectively. There were no significant differences in JOA scores and improvement rates between data collection periods at preoperative, 3-day postoperative, and 1-year postoperative follow-ups (P>0.05). Conclusion. For treating cCSM, both the piezosurgery and traditional tools led to significant neurological improvement. However, the piezosurgery was superior to the traditional tools in terms of surgical time, blood loss, and complication rate. Hence, piezosurgery was a safe and effective adjunct for ACDF treating cCSM.
Noninvasive Surveillance and Evolutionary Insight into Siadenovirus among Antarctic Penguins
Authors: Arce Rodrigo , Ferreiro Irene , Hurtado Joaquín , Aldunate Fabián , Perbolianachis Paula , Simón Diego , Moratorio Gonzalo , Moreno Pilar , Cristina Juan
Published: December 2023

Avian siadenoviruses infect diverse terrestrial and aquatic birds worldwide. Antarctica hosts several avian species that are susceptible to siadenovirus infection, such as penguins and South Polar skuas. However, the presence, diversity, and transmission of these viruses in Antarctic birds are poorly understood due to limited surveillance and sequence data. In this study, we performed a noninvasive surveillance of avian siadenoviruses using fecal samples collected from waterbirds at King George Island (part of South Shetland Islands, Antarctica) from late January to mid-February 2023. Polymerase chain reaction, sequencing, and phylogenetic analysis were used to investigate the occurrence, genetic diversity, and evolutionary relationships of these viruses in this unique environment. The results of these studies confirmed the presence of siadenoviruses in penguins living along the southeastern coast of King George Island. Distinct viral strains, specific to each penguin species studied, were found suggesting limited interspecies transmission and a complex viral ecosystem within Antarctic bird populations. Siadenovirus strains isolated from penguin’s species were genetically distinct from those infecting South Polar skuas. An in silico 3D modeling of hexon proteins from siadenoviruses gathered from gentoo penguins permitted to detect key amino acid substitutions in the FG2 domain that may affect capsid structure and function. The persistent prevalence of siadenoviruses in Antarctica underscores the need for ongoing surveillance to understand the evolutionary dynamics of viruses in this region. This study is the first to noninvasively detect siadenoviruses in Antarctic penguins, opening a new avenue for viral research. This approach not only sheds light on viral dynamics but also contributes to the conservation of Antarctica’s unique wildlife and biodiversity, especially in the face of increasing global warming.
Data from FBXW7-loss Sensitizes Cells to ATR Inhibition Through Induced Mitotic Catastrophe
Authors: O'Brien Siobhan , Ubhi Tajinder , Wolf Lucie , Gandhi Krishna , Lin Sichun , Chaudary Naz , Dhani Neesha C. , Milosevic Michael , Brown Grant W. , Angers Stephane
Published: December 2023

Abstract
FBXW7 is a commonly mutated tumor suppressor gene that functions to regulate numerous oncogenes involved in cell-cycle regulation. Genome-wide CRISPR fitness screens identified a signature of DNA repair and DNA damage response genes as required for the growth of FBXW7-knockout cells. Guided by these findings, we show that FBXW7-mutant cells have high levels of replication stress, which results in a genotype-specific vulnerability to inhibition of the ATR signaling pathway, as these mutant cells become heavily reliant on a robust S–G2 checkpoint. ATR inhibition induces an accelerated S-phase, leading to mitotic catastrophe and cell death caused by the high replication stress present in FBXW7−/− cells. In addition, we provide evidence in cell and organoid studies, and mining of publicly available high-throughput drug screening efforts, that this genotype-specific vulnerability extends to multiple types of cancer, providing a rational means of identifying responsive patients for targeted therapy.
Significance:
We have elucidated the synthetic lethal interactions between FBXW7 mutation and DNA damage response genes, and highlighted the potential of ATR inhibitors as targeted therapies for cancers harboring FBXW7 alterations.
Early Famine Exposure Results in Left Ventricular Remodeled, Diastolic Dysfunction and Systolic Function Preserved in Adults
Authors: Zhou Dan , Feng Xiaoxuan , Wu Shiping , Yan Mengqi , Wang Jiabin , Nie Zhiqiang , Feng Yingqing
Published: December 2023

Introduction: Malnutrition during a critical window of development in a fetus or infant can result in abnormal cardiac remodeling and function. It is uncertain whether the contribution of these effects continues to impact the cardiac remodeling and function of adults over the course of several decades of growth. Our study examined the impact of early Chinese famine exposure on cardiac remodeling, left ventricular (LV) diastolic function, and LV systolic function in adults. Methods: Participants at high risk of cardiovascular disease from the China Patient-Centered Evaluative Assessment of Cardiac Events Million Persons Project (PEACE MPP) were enrolled. The famine in China lasted from 1959 to 1962. A total of three groups were formed based on the participants’ birth dates: pre-famine group, famine exposure group, and post-famine group. Logistic regression and linear mixed models were used to explore the association between famine exposure and cardiac remodeling, LV diastolic function and LV systolic function in adults. Results: The study included 2,758 participants, the mean age was 57.05 years, 62.8% were female, 26.4% had LV hypertrophy (LVH), 59.6% had LV diastolic dysfunction (LVDD), and 10.5% had reduced global longitudinal strain (GLS). Compared to post-famine exposure, participants had independently increased risk of LVH in the famine exposure group (OR: 2.02, 95% CI: 1.60–2.56) and pre-famine exposure (OR: 1.36, 95% CI: 1.06–1.76). Compared to post-famine exposure, the risk of LVDD remarkably increased in the famine exposure group (OR: 3.04, 95% CI: 2.49–3.71) and pre-famine exposure group (OR: 1.87, 95% CI: 1.52–2.31). Famine exposure had no significant impact on GLS but was associated with a significant increase in LV ejection fraction (LVEF) and LV end-diastolic diameter (LVEDD). Significant interactions were observed between the effects of famine exposure and other clinical/sociodemographic variables (gender, systolic blood pressure [SBP] ≥140 mm Hg or not, high school or above or not, and annual income <50,000 RMB or not) on these outcomes. Conclusion: Exposure to famine, particularly during fetal and infant stages, increases the risk of LVH and LVDD in adults. However, the LV systolic function remains preserved. These impacts are more pronounced in females, individuals with SBP ≥140 mm Hg, those with low income, or those with high educational status.
The Challenge of Anticoagulation in Liver Cirrhosis
Authors: Eichholz Julia Carolin , Wedemeyer Heiner , Maasoumy Benjamin
Published: December 2023

Background: Advanced liver diseases are characterized by a number of changes in the hemostatic system. Due to the occurrence of bleeding events in patients with liver cirrhosis, there seems to be a hesitance to the administration of anticoagulant medications. This review summarizes challenges, recommendations, and current developments of anticoagulation in the cirrhotic patient. Summary: The risk of thrombotic events in patients with liver cirrhosis is at least as high as in patients with healthy liver function if not even higher. Standard laboratory markers do not truly reflect the complexity of changes that take place in the coagulative system and therefore cannot be used as a reference for risk of thrombosis or hemorrhage. Potential options for anticoagulant therapy are heparins, vitamin K antagonists, and direct-acting oral anticoagulants which come with differences in safety, application, possible side effects, and data availability for the patient cohort. Key Message: The administration of anticoagulation can be beneficial in patients with liver disease if the indication is present and bleeding prophylaxis has been established. Direct-acting oral anticoagulants appear to be a promising new approach with many improvements compared to conventional substances. Nevertheless, there is a need for further data and prospective trials on the use in patients with liver cirrhosis.
Eine Dermatomyositis mit ungewöhnlichen Befunden und letalem Ausgang
Authors: Polke Markus
Published: December 2023

Background: Interstitial lung disease (ILD) is a frequently observed comorbidity in autoimmune diseases such as dermatomyositis/polymyositis (DM/PM), and it is significantly associated with specific autoantibody types. One unique antibody type is the anti-transcription intermediate factor-1γ antibody (anti-TIF-1γ Ab), which has a positive rate of only 7%. It is often found in combination with malignancy and rarely with ILD, particularly rapidly progressive ILD (RPILD). In some cases, the presence of ILD in individuals with DM may indicate a paraneoplastic syndrome. Pneumocystis jiroveci pneumonia (PJP) typically occurs due to intensive immunosuppressive therapy, human immunodeficiency virus (HIV) infection, or malignancy, and rarely as an isolated condition. Case Presentation: A 52-year-old man with a history of rapid weight loss but non-HIV infected and not immunosuppressed who presented with fever, cough, dyspnea, weakness of the extremities, characteristic rash and mechanic’s hand. Pathogenic tests suggested PJP, laboratory tests suggested a single anti-TIF-1γ Ab positive DM, imaging suggested ILD, and pathology revealed no malignancy. RPILD and acute respiratory distress syndrome (ARDS) developed after anti-infection and steroid hormone therapy. After mechanical support therapy such as Extracorporeal Membrane Oxygenation (ECMO), the patient developed late-onset cytomegalovirus pneumonia (CMVP), complicated bacterial infection, and ultimately death. Additionally, we discuss the potential causes of rapid weight loss, the mechanisms by which anti-TIF-1γ Ab may lead to ILD, and the possible connection between anti-TIF-1γ Ab positivity, rapid weight loss, immune abnormalities, and opportunistic infections.
Hidden Y Chromosome Material and Congenital Cardiovascular Malformations in a Cohort of Turner Syndrome Patients with 45,X Blood Karyotype
Authors: Udo Emediong Q. , Truly Tate , Peters Andrew , Prakash Siddharth K. , Rivera Michelle , Rodriguez-Buritica David Felipe
Published: December 2023

Introduction: Bicuspid aortic valve is the most common congenital cardiac malformation (CCM) in adults and is 30–50 times more frequent in Turner syndrome (TS). We hypothesize that both X and Y chromosome dosages contribute to the prevalence of CCM in TS. The recognition of genotype-phenotype correlations may improve risk stratification of patients with 45,X karyotypes who have cryptic Y chromosome mosaicism. Methods: Utilizing data and samples from the UTHealth Turner Syndrome Research Registry, we correlated Y chromosome DNA identified by multiplex quantitative PCR and SNP microarrays with the presence of congenital heart lesions. Results: We identified Y chromosome DNA in more than 10% of registry participants, including 2 participants who had no detectable Y DNA by karyotype or SNP microarray. Conclusions: There were no significant correlations between the presence of Y DNA and CCM.
Tyrosine Hydroxylase Knockdown at the Hypothalamic Supramammillary Nucleus Area Induces Obesity and Glucose Intolerance
Authors: Zhang Yahong , Tsai Tsung-Huang , Ezrokhi Michael , Stoelzel Carl , Cincotta Anthony H.
Published: December 2023

Introduction: The supramammillary nucleus (SuMN) exerts influences on a wide range of brain functions including feeding and feeding-independent fuel metabolism. However, which specific neuronal type(s) within the SuMN manifest this influence has not been delineated. This study investigated the effect of SuMN tyrosine hydroxylase (TH) (rate-limiting enzyme in dopamine synthesis) knockdown (THx) on peripheral fuel metabolism. Methods: SuMN-THx was accomplished using a virus-mediated shRNA to locally knockdown TH gene expression at the SuMN. The impact of SuMN-THx was examined over 35–72 days in rats least prone to developing metabolic syndrome (MS) – female Sprague-Dawley rats resistant to the obesogenic effect of high fat diet (HFDr) and fed regular chow (RC) – upon body weight/fat, feeding, glucose tolerance, and insulin sensitivity. The influence of HFD, gender, and long-term response of SuMN-THx was subsequently investigated in female HFDr rats fed HFD, male HFDr rats fed RC, and female HFD-sensitive rats fed RC over 1 year, respectively. Results: SuMN-THx induced obesity and glucose intolerance, elevated plasma leptin and triglycerides, increased hepatic mRNA levels of gluconeogenic, lipogenic, and pro-inflammatory genes, reduced white adipose fatty acid oxidation rate, and altered plasma corticosterone level and hepatic circadian gene expression. Moreover, SuMN-THx increased feeding during the natural resting/fasting period and altered ghrelin feeding response suggesting ghrelin resistance. This MS-inducing effect was enhanced by HFD feeding, similarly observed in male rats and persisted over 1 year. Discussion/Conclusion: SuMN-THx induced long-term, gender-nonspecific, multiple pathophysiological changes leading to MS suggesting SuMN dopaminergic circuits communicating with other brain metabolism and behavior control centers modulate peripheral fuel metabolism.
The effect of entrepreneurial readiness, adversity quotient, and social intelligence on employability students
Authors: Zulmi Nizar , Tentama Fatwa
Published: December 2023

Vocational high schools aim to create graduates who are ready to work, but in reality, many graduates are not ready to work at this time. Low employability is the main problem. This study aims to design and test a theoretical model of the effect of entrepreneurial readiness, adversity quotient, and social intelligence on employability in vocational high school students. The population of this study was students of class XII vocational high school "X" in Moyudan, Sleman, which consisted of 209 students. The sample in this study was 68 students selected by cluster random sampling technique. The data collection method used employability scales, entrepreneurial readiness scales, adversity quotient scales, and social intelligence scales. Data were analyzed using the structural equation model (SEM) through the Smart Partial Least Square 3.3.9 program. The results of this study are the formation of a model of the influence of entrepreneurial readiness, adversity quotient, and social intelligence on employability that is appropriate (fit) with empirical data. The adversity quotient has a positive and very significant effect on employability, while entrepreneurship readiness and social intelligence have no impact on employability. This model can be used as a valid reference in developing employability variables.
The role of gamification implementation in improving quality and intention in software engineering learning
Authors: Wahyuningsih Tri , Sediyono Eko , Hartomo Kristoko Dwi , Sembiring Irwan
Published: December 2023

Gamification can make learning more fun and engaging for students. Software engineering can utilize gamification to help students learn and improve their skills from the complexity of software engineering. This study used quantitative research to examines perceived ease of use, student satisfaction, and perceived usefulness to measure gamification quality, which can have an impact on software engineering intention, namely intention, loyalty, and participation in following and understanding software engineering materials. The data was collected based on an online questionnaire survey, 90 data were collected and then measured and analyzed using SmartPLS 3. The results showed that perceived ease of use, student satisfaction, and perceived usefulness have a significant influence on gamification quality, which also leads to a positive impact on software engineering intention. This research guides teachers and educational institutions that gamification is very successful as a learning medium to simplify complex information to be more interactive.
Implementation of the 8+i link and match vocational school program
Authors: Wahjusaputri Sintha , Rahmanto Muhammad Arifin , Suciani Suciani , Kustantini Susi
Published: December 2023

This research aims to create the 8+i link and match model as an embodiment of a healthy learning ecosystem between schools and the worlds of business and industry. The research technique is a mix of quantitative and qualitative research methodologies. The qualitative technique develops a basic list of success characteristics using meta-ethnography, whereas the quantitative approach defines the link between the variables under examination by establishing or building many latent variables that explain the relationship between variables using Aiken's formula and SPSS version 26. The study's findings demonstrate the success of the 8+i link and match model between Muhammadiyah 1 Ciputat vocational high school/Sekolah Menengah Kejuruan (SMK) Muhammadiyah 1 Ciputat and industry in generating efficiency and mutual benefits for both parties, not just ordinary collaboration, but intense collaboration from the curriculum development, learning, and industrial work practices designed collaboratively. The Implication of the 8+i link and match model if correctly implemented is that the industry will profit because the training expenses is reduced, and vocational high schools will benefit because their graduates is absorbed by the industry. Recommendations for the vocational high school curriculum must include schools, and industry, also Teaching personnel must include practitioners from industry as well as instructors from schools.
Development of a mathematics module on circle material based on the small group discussion model
Authors: Lumbantoruan Jitu Halomoan , Ditasona Candra
Published: December 2023

This research aims to produce a mathematics module on circle material based on the small group discussion model to improve learning outcomes. The fact is that there are 48% of students who get low mathematics learning outcomes. Another fact is that at the high school level, 62% of students in circle material scored below the minimum completeness criteria. Urgent development research was carried out to produce circular module products. The method in this research is research and development (RD). The subjects and objects of the research were high schools and there were 32 students. Data collection techniques, material expert instruments, teachers, and student data were also obtained from the results of student pre-tests and post-tests. The data was analyzed by adding up all the assessment scores on the instruments adding up the test results and averaging the individual and classical scores. The results, and assessment of all module components by material experts, mathematics teachers, small group trials, and large group trials were 88.29%, 90.45%, 93.50%, and 92.10% in the very good category. The average score of students' post-test results is 87.50. Conclusion, this circle module can improve student learning outcomes significantly.
Development of DIGaKiT: identifying students’ alternative conceptions by Rasch analysis model
Authors: Samsudin Achmad , Azizah Nurul , Fratiwi Nuzulira Janeusse , Suhandi Andi , Irwandani Irwandani , Nurtanto Muhammad , Yusup Muhamad , Supriyatman Supriyatman , Masrifah Masrifah , Aminudin Adam Hadiana , Costu Bayram
Published: December 2023

Alternative conceptions become obstacles in physics. However, it is difficult to find instruments that can identify students' alternative conceptions, especially in gases kinetic theory (DIGaKiT). The purpose of this research was to development of diagnostic instrument of DIGaKiT in identifying students’ alternative conceptions by Rasch analysis model. The research method used the defining, designing, developing, and disseminating (4D). The samples are 31 students (12 male students and 19 female students, their ages were typically 16 years old) at one of the senior high schools at Belitung. Rasch analysis was used to identify the validity, reliability, and distribution of students' alternative conceptions. The result is that the level of validity and reliability of the instrument is in a good category. Meanwhile, alternative conceptions of the kinetic theory of gases can be identified in all questions, and the questions with the highest alternative conceptions are questions with code Q11 (77%) and the lowest are questions with codes Q1, Q5, and Q6 (4%). Therefore, teachers must design learning processes that can reduce students’ alternative conceptions of the kinetic theory of gases material.
The role of motivation factors in education for the development of student’s environmental leadership in HEIs
Authors: Rudyshyn Serhii , Truskavetska Iryna , Romanyuk Svitlana , Vakal Anatolii , Hnatyuk Vitaliy
Published: December 2023

This study aimed to explore the motivational factors influencing the development of environmental leadership qualities among students in higher educational institutions (HEIs). The study used surveys based on the methods of Zhang and Nunez Alonso, the Karpenko criteria, and the methods of Chen and Semedo. The study revealed that the proposed program, designed to enhance motivation and foster environmental leadership qualities, positively impacted students' motivation. Approximately one-third of students exhibited only an elementary level of environmental culture, indicating a lack of focus on environmental protection. However, applying the proposed approach increased motivation, environmental culture, and environmental leadership among students. Furthermore, a correlation was identified between motivation factors, environmental culture, and environmental leadership qualities. Future research should explore strategies for promoting ecological behavior among students, schoolchildren, and adults.
Principles and problems of policy implementation reconsiderations for effective secondary school administration
Authors: Akporehe Dorah Ataphia , Comfort Osiobe , Egoh Blessing
Published: December 2023

Policy implementation has presented the Nigerian educational system with countless obstacles cum problems. This research explored the principles and problems of policy implementation reconsiderations for effective secondary school administration. The study adopted a descriptive research design. The study population was 286 principals. The study sample was 229 principals drawn through a simple random sampling, representing 80% of the population. An instrument, principles and problems of policy implementation for effective secondary school administration was utilized for data collection. Cronbach alpha established a reliability coefficient of 0.89. Mean and standard deviation were used for data collection, while a t-test was utilized to test the hypotheses at a 0.05 significance level. The researchers found that the principles of policy implementation for effective secondary school administration are founded on ensuring a positive and clear policy statement, flexibility in the policy statement, fact-based policy statement, effectiveness in policy statement communication, openness to review, and properly documented in writing. It was recommended that school principals provide copies of the school policy to all the teachers. The principals should not be subjective in implementing policy for effective school administration. The implication of the study is that principals should adopt effective principles for policy implementation.
Intelligent MPPT control for SEPIC-Luo converter in grid tied photovoltaic system
Authors: Prasad D. Thivya , Anandhakumar R. , Balamurugan P.
Published: December 2023

Grid connected solar photovoltaic (SPV) systems are becoming more and more common due to steadily rising energy demand. The advantages of photovoltaic power generation, such as its eco-friendliness, low maintenance requirements, and lack of noise, are making it as a significant renewable energy source (RES). This framework presents the modeling and control design of PV grid tied system implemented with integrated single ended primary inductance (SEPIC) Luo converter. The main goal of this work includes investigating solar PV system behaviour and creating an effective grid connected solar power. Solar PV module tracks maximum power, with an aid of chaotic cascaded fuzzy a maximum power point tracking (MPPT) has developed. The DC voltage obtained is fed to 1Φ voltage source inverter (VSI) for conversion of AC voltage. In comparison to typical PWM control, the spectrum performance of the examined voltages is improved by adjusting the nominal duty cycle of main switch of SEPIC-Luo converter. So that PV output impedance is equivalent to DC-DC converter's input resistance. Finally, the obtained AC voltage is supplied to 1Φ grid for further applications. With less THD, an efficiency of 96% is achieved when the implementation of the suggested system is carried out using MATLAB/Simulink.
Numerical model of variable valve timing distribution for a supercharged diesel engine
Authors: Benallal Abdellah , Hayyani Mohamed Yasser , Mhadhbi Ghazi , Ilinca Adrian
Published: December 2023

Recently, there's been a strong drive to improve performance of diesel engines while reducing their greenhouse gases emissions. Techniques like exhaust gas recirculation, turbocharging, and variable valve timing have become widespread. The last technique fine-tunes valve operation based on engine speed, which optimize efficiency and power output while saving fuel. This study zeroes in on a specific 4-cylinder, 4-stroke diesel engine of 1.56-liter, GT-Power software is employed to examine a supercharged version and implementing diverse valve lift techniques. The findings are revealing a substantial 30% increase in power output. At 1000 rpm, power rises from 15.1 kW for the standard engine to 19.72 kW for the modified version. For higher engine speeds, the improvements become even more pronounced, reaching a 66% boost compared to the standard configuration. Furthermore, the newly configured engine showcases an impressive 13% decrease in fuel-specific consumption at elevated engine speeds, contributing to enhanced technical performance and fuel efficiency. The numerical model developed in this study holds the potential to aid in the design of novel diesel engines equipped with variable valve timing systems. To lend further support to these findings, experimental validation is recommended.
Voltage stability of a photovoltaic DC microgrid using fuzzy logic controller
Authors: Manohar Kalangiri , Padma Kottala
Published: December 2023

This article employs a fuzzy logic controller (FLC) to investigate voltage stability in a PV-based DC microgrid. Several photovoltaic (PV) modules, a DC-DC converter, and loads make up the microgrid. Due to the widespread use of intermittent PV power, voltage stability is a crucial problem for DC microgrids and is difficult to accomplish. This study proposes an FLC-based voltage control technique that leverages input factors including PV output power, DC-DC converter duty cycle, and load current to identify the best course of action for preserving the system's voltage stability. The FLC's performance is assessed by simulation, and it is meant to be resilient to parameter fluctuations and uncertainties. The simulation results demonstrate that the suggested FLC-based control strategy successfully maintains the microgrid's voltage stability under a variety of operational circumstances, including changing solar irradiance and load variations. Moreover, the FLC performs better than other control methods.
Optimization of controllers using soft computing technique for load frequency control of multi-area deregulated power system
Authors: Jain Dharmendra , Bhaskar M. K.
Published: December 2023

Given the changing nature of power systems, it is challenging to optimize the controller for controlling load frequency problems. Distributed power generating sources and power system reorganization with multi-sources and multi-stakeholders make traditional load frequency control approaches unsuitable for current power systems. This research provides the comparative analysis of regulation of the load frequency in a multiple-area deregulated electricity system with the help of soft computing. In a reorganized electrical system, the major objectives of load frequency control (LFC) are to set up system frequency into acceptable limit, swiftly return the frequency to the setpoint, reduce tie-line power flow fluctuations across adjacent control zones, and track load demand agreements. To achieve LFC's goals, proportional integral derivative (PID) gain values must be tuned, for optimization purpose, soft computational methods are used in this present work. MATLAB/Simulink simulation results show that soft computing controllers can keep tie line power interchange within contracted constraints and frequency variation within the allowed range. This article compares auto tuned PID, genetic algorithm (GA), and particle swarm optimization (PSO) controllers in unregulated circumstances, load frequency regulation of two-area power systems.
Effect of computer workstation set-ups on muscle oxygen saturation and perceived fatigue
Authors: Radin Umar Radin Zaid , Yin Tiong Jing , Ahmad Nadiah
Published: December 2023

Multiple literatures show evidences of how office workstation set-ups can influence muscle activities. However, the relationship between the postural adoption due to workstation setup and its effect to muscle oxygen saturation among office workers is unclear. The aim of this study was to investigate trends of muscle oxygen saturation and perceived fatigue ratings between different upper limbs posture variations among representative computer users. A repeated measure experiment was conducted on 15 participants to compare the muscle oxygen saturation and perceived fatigue ratings between four different office work posture variations. Parametric and non-parametric statistical analyses were conducted to analyze significant differences on the dependent parameters. Data analysis showed statistically significant trends (p≤0.050) of lower muscle oxygen saturation in workstation set-ups in which participants were adopting raised shoulder and extended arm positions. In addition, the findings revealed that the perceived fatigue ratings on the shoulder, upper arm and lower arm are the lowest (p≤0.050) in workstation condition where subject can adopt neutral postures. The results highlight the effect of good office workstation setup and work postures to individual muscle oxygen saturation and fatigue levels.
Nursing student caring behaviours: a systematic review
Authors: Permana Bhakti , Yusuf Ah. , Bakar Abu
Published: December 2023

Caring is central to nursing and requires scientific professional skills and knowledge. Numerous definitions highlight the fact that there is a range of perspectives regarding the caring behaviors. The purpose of this study was to provide a summary of caring behaviors among nursing students in order to depict a more comprehensive view, which could be used as foundational data for the argument that cultivating caring behaviors should be an early focus of the nursing curriculum. Article selection was guided by the preferred reporting items for systematic reviews and meta-analyses (PRISMA) Statements. Literature searches were conducted in June 21, 2022 in PubMed, cumulative index to nursing and allied health (CINAHL), and (OVID). The following search blocks were generated: nursing students, caring behavior, and education. About 318 were found using primary search descriptors and 19 studies were included in the review. All research was published between 2016 and 2020. The majority of studies were conducted using a cross-sectional design, two studies used prospective, and one study used a retrospective design. The caring behavior of nursing students varies depending on the country and instrument used, ranging from a moderate score to a high score, and varies from one study year to the next. The most dominant caring behavior domains reported are the domains of instrumental caring/physical caring and expressive caring/emotional caring. This study adds to the existing literature on nursing care and explains the universality of the concept of care from multiple theoretical perspectives. Caring interventions should be used to help students develop clinically-relevant caring behaviors.
The impact of the pandemic on environmental health from the perspective of energy sector
Authors: Asri Novena Damar , Legowo Evita H , Yusgiantoro Purnomo
Published: December 2023

This study reviews the impact of the COVID-19 pandemic on environmental health through the energy sector, based on the close relationship between energy, the economy, and the environment. The lockdown policy to contain the spread of the disease has hampered the global economy. Due to the close relationship between energy and the economy, the decline in global economic growth can be easily indicated by the decrease in world energy consumption. However, this study argues that this situation also opens the opportunity of restoring environmental health. Thus, the objective of the study is to find the opportunity and the lesson that can be learned from the COVID-19 pandemic. This study employs a qualitative method that combines descriptive analysis and literature review. It involves a review, processing, and observation of quantitative data (statistics) and qualitative data. This study finds that the pandemic opens opportunities to relieve the environment damaged by fossil-dominated energy consumption to pursue economic growth. However, this study also finds the challenge to overcome and lesson learned. The challenge is the two-way pressure from demand and prices that renewables must face. The lesson to be learned is mainly to reduce the dependency on fossil energy sources, primarily if it is imported. However, on top of that, the government must be able to seize the opportunities to overcome the challenge. Thus, this study is expected to provide an optimistic view of taking advantage of the blessing in disguise of the pandemic to rehabilitate environmental health through the energy sector.
Knowledge and attitudes towards antibiotic resistance among health profession students in Indonesia
Authors: Syahniar Rike , Farsida Farsida , Kosasih Audia Nizhma Nabila , Mardhia Mardhia , Bekti Heri Setiyo , Marpaung Nurasi Lidya E. , Darmawan Ade , Indriyani Indriyani , Husna Ismalia , Amany Hana Amirah
Published: December 2023

Abuse and overuse of antibiotics cause the increasing prevalence of antibiotic resistance. Doctors, nurses, midwives, and pharmacy professionals play an essential role in providing information and education on the use of antibiotics to the public. This study aims to compare and identify the factors that influence the knowledge and attitudes of students’ medicine, midwifery, pharmacy, and nursing toward antimicrobial resistance. An online crosssectional survey involving 530 medical, midwifery, pharmacy, and nursing students who are currently in the clinical or professional study stage. The Mann–Whitney U test and the Kruskal–Wallis test was run to assess differences in the mean scores of knowledges and attitudes. Factors related to knowledge and attitudes regarding antibiotic resistance were analyzed using linear regression. Most (93%) students have a good level of knowledge and have a positive attitude 49.81%, neutral 43.78%, and negative 6.41%. There was a relationship between age (p=0.012), major (p=0.000), source of information (p=0.013), and knowledge and attitudes about antibiotics (p<0.05). We conclude that there are differences in knowledge and attitudes toward antibiotic resistance among clinical-stage students of medicine, midwifery, pharmacy, and nursing. We found that essential knowledge and attitudes should be revised regarding antibiotic resistance.
Theory of planned behavior in creating disease prevention behavior
Authors: Prasetya Hanung , Darmayanti Aquartuti Tri , Setyorini Yuyun
Published: December 2023

Human behavior, in dealing with pandemic, becomes one of the key factors during the speed of an outbreak. In this way, individual and social responsibility are needed to determine behaviors, end the pandemic, and anticipate for the next outbreak. The purpose of this systematic review is to provide structured information about the results of applying the theory of planned behavior (TPB) in concern to create COVID-19 preventive behavior (CPB) as the case example. This systematic review was compiled by searching articles using the keywords "theory of planned behavior"[MeSH] AND COVID-19 preventive behavior. ("theory of planned behavior"[MeSH]) AND "hand disinfection"[MeSH]. "Theory of planned behavior" AND "social distancing." "Theory of planned behavior" AND "wearing mask." The search was obtained from PUBMED and Google Scholar. The 13 articles met the requirements to be reviewed qualitatively on the implementation of TPB. The results showed that TPB was effective to bring about the prevention behavior of infectious disease, such as COVID-19. Other significant aspects are intentions, norms, and behavioral control. The TPB model can be applied for health promotion in creating prevention behavior of infectious disease.
Knowledge, eating patterns, and hypertension among elderly in the coastal areas of Bangkalan, Indonesia
Authors: Festi Wiliyanarti Pipit , Wulandari Fitri , Sumarliyah Eni
Published: December 2023

Hypertension is a non-communicable disease which frequently occurs in the elderly. This study aimed to assess hypertension and knowledge as well as hypertension and eating patterns among elderly in the coastal areas. The design of this study is cross-sectional study. The population in this study were elderly with hypertension who lived in the Sukolilo Health Center area in Bangkalan. The sample was selected using simple random sampling of 110 elderlies. The inclusion criteria were elderly who were aged ≥60 years old with systolic blood pressure (SBP) of >140 mmHg and diastolic blood pressure (DBP) of >90 mmHg. The instrument was food frequency questionnaire (FFQ). The blood pressure was measured by using standard operating procedures. The data were analyzed by the Spearman’s rank test. The results indicated that most of the respondents were lack of knowledge of 66 people (29.1%) and had a poor eating pattern of 78 people (70.9%). Most of the respondents were in the moderate hypertension of 52 people (47.3%). The statistical analysis indicated a relationship between knowledge and the incidence of hypertension of p=0.004 (p<0.05; r=0.974). In conclusion, understanding about blood pressure control is required to prevent hypertension.
RGB-based colorimetric method for the analysis of water alkalinity using Cordyline fruticosa extracts as visual indicator
Authors: Parungao Christian Alex C. , Reyes Darwin F.
Published: December 2023

Leaf extracts of Cordyline fruticosa was used as a natural visual indicator for a digital image-based analytical procedure for the measurement of water alkalinity. A smartphone and ImageJ were used to capture and process the images, respectively. This work sought to develop and evaluate a greener strategy of using of Cordyline fruticosa leaf extract as natural indicator, in a digital image-based colorometric set-up using smartphone. Under optimized conditions, the linear working range was from 40 to 160 ppm of CaCO3, with a calibration sensitivity of 5 x 10-3 ppm and a coefficient of correlation (r2) = 0.998. The limit of detection and quantification were 39 ppm and 117 ppm, respectively. A 10,000 ppm CaCO3 solution was tested using the proposed method and the results statistically agree with the results obtained from titrimetric methods. The study presented a simple analytical procedure that can be develop and apply for the assessment of pollution that could pose serious human and environmental health hazards.
The role of body appreciation and boredom on married men’s sexual satisfaction
Authors: Josephine Angelique Felicia , Sukamto Monique Elizabeth , Redita Natasya Engga
Published: December 2023

Adult male appreciation of his body can affect sexual satisfaction. In addition, boredom caused by a lack of variety in sexual relations can also have an impact on sexual satisfaction in marriage. The aim of this study was to examine the role of body appreciation in predicting increased sexual satisfaction, either directly or indirectly through the mediation of sexual boredom, in early and middle-aged married men. Data were collected from a total of 382 participants (mean age 38 years) using a cross-sectional survey method with convenience sampling. Participants completed the extended satisfaction with life scale (ESWLS), body appreciation scale-2 (BAS-2), and sexual boredom scale (SBS). The results showed that sexual boredom partially mediated the indirect role of body appreciation in predicting sexual satisfaction (B=0.159; z=4.383; sig.=0.001<0.05) because body appreciation can also directly predict increased sexual satisfaction (B=0.814, t=11.418; sig.=0.001<0.05). This result indicates that body appreciation as an internal factor plays a greater role in predicting high sexual satisfaction in early and middle adulthood men.
Prevention and control of diabetes mellitus complications in productive population in rural
Authors: Nurlatif Rr. Vita , Sumardiyono Sumardiyono , Rahardjo Setyo Sri
Published: December 2023

In Pekalongan Regency, Central Java, Indonesia, cases of productive population with diabetes mellitus have rapidly increased over the past three years. With regard to individual-based problems prevention and management, this is not sufficiently balanced. From the standpoint of the provider, this study examines attempts to prevent and control diabetes mellitus in productive population, including obstacles and limitations. With a focus on three rural areas (Wiradesa, Tirto I and Kedungwuni I Sub-Districts), qualitative study included 75 productive-age diabetics and 30 breadwinners. In-depth interviews and focus group discussions were used to gather data, which was then thematically analyzed. Three rural locus with the highest prevalence of diabetes mellitus in productive population were found in the results. Through screening for non-communicable diseases at integrated service post (Posyandu), chronic disease management programs and cross-sectoral activities, there are numerous initiatives for the prevention and management of complications. The challenges include constantly changing programmers, programmers with many assignments, inadequate target awareness and low motivation, as well as a worse recording and reporting system. Such that fundamental information on both individual and public health cannot be accessed. Based on individual emphasis, recording and reporting, several programs for complication prevention and management are required to identify the range of non-communicable diseases.
Factors influencing unable to eat healthy and nutritious food among Indonesian onset COVID-19 pandemic
Authors: Mamahit Adi Yeremia , Suryani Dyah , Suyitno Suyitno , Akbar Hairil , Sari Dewi Puspito , Rahmawati Ade , Nuraeni Tating , Supriatin Supriatin
Published: December 2023

Nearly every aspect of household life has been touched by the coronavirus disease (COVID-19) pandemic, including the amount and quality of food consumed by the family. This study aimed to examine the factors associated with unable to eat healthy and nutritious food onset of the COVID-19 pandemic in Indonesia. This study used data from Rapid Gender Assessment Survey developed by United Nations Women from September to December 2021. Totally 2,285 respondents aged >18 years old with access to mobile phones have been selected by random digit dialing (RDD). The multivariate analysis revealed living in the town, who graduated from secondary, primary, and no education, households with five or more members, income changes during the pandemic, and those who had not completed vaccine COVID-19 were 1.44; 1.57; 1.73; 2.06; 1.26; 2.74; 1.29 times more likely to be unable to eat healthy and nutritious food. In conclusion, 39.17% of respondents were unable to eat healthy and nutritious food, and factors of changes in income had the biggest impact. Future research could examine the impact of the pandemic on people's capacity to access and buy wholesome food.
Identification of Clinical Drivers of Left Atrial Enlargement Through Genomics of Left Atrial Size
Authors: Agrawal Vineet , Manouchehri Ali , Vaitinadin Nataraja S. , Shi Mingjian , Bagheri Minoo , Gupta Deepak K. , Kullo Iftikhar J. , Luo Yuan , McNally Elizabeth M. , Puckelwartz Megan J. , Ferguson Jane F. , Wells Quinn S. , Mosley Jonathan D.
Published: December 2023

BACKGROUND:

Greater left atrial size is associated with a higher incidence of cardiovascular disease and mortality, but the full spectrum of diagnoses associated with left atrial enlargement in sex-stratified clinical populations is not well known. Our study sought to identify genetic risk mechanisms affecting left atrial diameter (LAD) in a clinical cohort.

METHODS:

Using Vanderbilt deidentified electronic health record, we studied 6163 females and 5993 males of European ancestry who had at least 1 LAD measure and available genotyping. A sex-stratified polygenic score was constructed for LAD variation and tested for association against 1680
International Classification of Diseases
code–based phenotypes. Two-sample univariable and multivariable Mendelian randomization approaches were used to assess etiologic relationships between candidate associations and LAD.

RESULTS:

A phenome-wide association study identified 25
International Classification of Diseases
code–based diagnoses in females and 11 in males associated with a polygenic score of LAD (false discovery rate q<0.01), 5 of which were further evaluated by Mendelian randomization (waist circumference [WC], atrial fibrillation, heart failure, systolic blood pressure, and coronary artery disease). Sex-stratified differences in the genetic associations between risk factors and a polygenic score for LAD were observed (WC for females; heart failure, systolic blood pressure, atrial fibrillation, and WC for males). By multivariable Mendelian randomization, higher WC remained significantly associated with larger LAD in females, whereas coronary artery disease, WC, and atrial fibrillation remained significantly associated with larger LAD in males.

CONCLUSIONS:

In a clinical population, we identified, by genomic approaches, potential etiologic risk factors for larger LAD. Further studies are needed to confirm the extent to which these risk factors may be modified to prevent or reverse adverse left atrial remodeling and the extent to which sex modifies these risk factors.