bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessing emotions in pigs: determining negative and positive mental states
Authors:   Bristol Veterinary School, University of Bristol, UK, Murphy Eimear , Melotti Luca ,   Bristol Veterinary School, University of Bristol, UK, Mendl Michael ,   Bristol Veterinary School, University of Bristol, UK
Published: February 2021

This chapter reviews assessing emotions in pigs, specifically focusing on the ways of determining negative and positive mental states. It begins by examining behavioural indicators of emotion such as behavioural tests, qualitative behaviour assessment, vocalisations, play behaviour, defence cascade responses and facial expression and body posture. The chapter also assesses cognitive indicators of emotion in pigs and judgement bias. This is followed by a discussion of neurophysiological indicators of emotion in pigs, focusing specifically on the physiology of negative and positive emotions.
El artista modernista y el discurso psiquiátrico: Los Raros de Rubén Darío y la mirada médica finisecular
Authors:   Universidad Nacional de Tres de Febrero, Gamarra La Rosa José Luis ,   Pontificia Universidad Católica del Perú
Published: February 2021

This article focuses on the relationship between literary discourse and psychiatric discourse in the late 19th century; especially, in what refers to the establishment of knowledge about the abnormal and the configuration of artistic genius as a pathology. Furthermore, the work aims to examine the construction of a “rhetoric of the disease”, their strategies and functions, in Los Raros (1896-1905) by Rubén Darío, from the analysis of the normal/abnormal conceptual binomial and the emergence of psychiatric discourse as power of normalization in end-of-century artistic productions. The author proposes that the literary portraits that Darío draws in his work reveal a tension between two types of gaze on the normal and the pathological. On the one hand, the artistic gaze of end-of-century artists with an ambivalent discourse that informs about a use of a pathological genius as an artistic ideal; on the other, the psychiatric gaze, which establishes a series of diagnostic and classification devices for abnormal subjects. Darío will face this clinical gaze from the pages of his literary portraits through a discourse that dismantles the episteme of the medical-psychiatric discourse and questions the fluctuating place that modernist writers occupy in the incipient Buenos Aires consumer society.
Salones darianos: fotografía, arte y literatura en la crónica modernista
Authors:   Universidad de Buenos Aires, Salas Klocker Luis Alberto
Published: February 2021

Based on what it has been called the salones darianos, that is, the chronicles that Darío wrote about several art exhibitions that he visited, this work aims to reflect on the role that the image played in the cultural project of modernismo. At the turn of the century, the image’s technological reproducibility broke into both the press and art salons. This was perceived by Darío, who explored the relationship of the photographic image with the incipient cultural industries. Less known than Mundial and Elegancias magazines, the first of Darío’s projects that included a strong presence of images, that is, the “Suplemento Semanal Ilustrado” of La Nación, goes beyond the lettered bias of literary criticism and opens new horizons to modernismo studies. Although this magazine was not directly under his direction, it does coincide with one of the high points of his career in the Argentine newspaper. Darío was for a time the main animator of this magazine, so his performance can be read as a scale model of his operations in pursuit of an expanded artistic field.
OKUL ÖNCESİ EĞİTİM ETKİNLİK KİTABININ YENİLENMİŞ BLOOM TAKSONOMİSİ’NE GÖRE İNCELENMESİ
Authors: YILMAZ Arif , AKBABA Fikrinaz Damla , HALIPINAR Fatma Merve , ORAL Selin , ULUSOY ÜNLÜ Ayşenur
Published: February 2021

Eğitim-öğretim dönemi boyunca sınıf içinde uygulanabilecek etkinlikler okul öncesi eğitim programının temelini oluşturmaktadır. İyi ve etkili bir şekilde planlanmış etkinlikler hem çocukların gelişimine hem de öğretmenlerin mesleki deneyimlerine katkı sağlaması açısından çok önemlidir. Bu doğrultuda, Millî Eğitim Bakanlığı Temel Eğitim Genel Müdürlüğü tarafından öğretmenlere rehber olması için “Okul Öncesi Eğitim Etkinlik Kitabı” hazırlanmıştır. Bu araştırmada, etkinlik kitabında yer alan etkinliklerin kazanım ve göstergelerinin Yenilenmiş Bloom Taksonomisi’ne göre hangi basamakta yer aldığını ortaya koymak amaçlanmıştır. Araştırma, nitel araştırma yöntemlerinden biri olan durum çalışması olarak gerçekleştirilmiş ve doküman incelemesi tekniği kullanılmıştır. Çalışma çerçevesinde kitapta yer alan 341 etkinliğin 27’si basım hataları sebebiyle değerlendirmeye alınmamış, geriye kalan 314 etkinliğin içerdiği 1234 kazanım Yenilenmiş Bloom Taksonomi’sine göre bilişsel süreçler bakımından sınıflandırılmıştır. Kazanımların sınıflandırılmasında “Kazanım Değerlendirme Formu” ve “Etkinlik Değerlendirme Formu” kullanılmıştır. Sonuçlara göre, kazanımların büyük çoğunluğunun bilişsel gelişim alanına yönelik olduğu, kazanımların birçoğunun 3. basamak olan uygulama basamağında yer aldığı ve analiz, değerlendirme, yaratıcılık gibi üst basamaklarda yer alan kazanım sayısının daha az olduğu, kazanımların yoğunluğun ilk üç basamakta yer aldığı görülmüştür. Araştırmadan elde edilen bulgular neticesinde, kitaptaki kazanım ve göstergelerin üst düzey becerileri destekleyecek şekilde kullanılması ve gelişim alanlarının etkinlik türlerinde dengeli dağılması gerektiği ortaya çıkmıştır.
Mathematical modelling and verbal abilities: How they determine students’ ability to solve mathematical word problems?
Authors: Sarjana Ketut , Hayati Laila , Wahidaturrahmi Wahidaturrahmi
Published: February 2021

[English]: This study aims to determine the level of lower secondary school students’ ability in solving mathematical word problems and how much both mathematical modelling ability and verbal ability influence the ability to solve word problems in the implementation of Kurikulum 2013 (Curriculum 2013). This study involved 411 students as samples determined by stratified proportional random sampling technique. The test used was declared valid through construct validity and reliability with Cronbach's alpha. Data were analyzed descriptively and inferentially. Descriptively, the students' ability in solving mathematical word problems was classified as medium. Meanwhile, inferentially, results were obtained indicating that: (1) students' verbal ability is significantly influential on the ability to solve word problems by 47.6%; (2) the students’ ability in mathematical modelling is significantly influential on the ability to solve word problems by 84.6%; and (3) students' verbal and mathematical modelling abilities are significantly influential on the ability to solve word problems by 87.8%. This indicates that the increase in students' ability to solve mathematical word problems will be more optimal if the verbal ability and the mathematical modelling ability are considered simultaneously, rather than focusing on one ability only.
 Keywords: Verbal ability, Mathematical modelling, word problems, Curriculum 2013
 [Bahasa]: Penelitian ini bertujuan menentukan tingkat kemampuan siswa SMP menyelesaikan soal cerita matematika dan seberapa besar pengaruh kemampuan membuat model matematika dan verbal terhadap kemampuan menyelesaikan soal cerita pada pelaksaaan kurikulum 2013. Penelitian ini melibatkan 411 siswa sebagai sampel yang ditentukan melalui teknik stratified porposional random sampling. Tes yang digunakan dinyatakan valid melalui uji validitas konstruk dan reliabel dengan Alpha Cronbach. Data dianalisis secara deskriptif dan inferensial. Secara deskriptif, kemampuan siswa dalam menyelesaikan soal cerita matematika masih tergolong sedang. Sedangkan secara inferensial diperoleh hasil bahwa (1) kemampuan verbal siswa berpengaruh secara signifikan terhadap kemampuan menyelesaikan soal cerita, dengan kemampuan verbal 47,6%; 2) kemampuan siswa dalam membuat model matematika berpengaruh secara signifikan terhadap kemampuan menyelesaikan soal cerita, dengan kemampuan membuat model matematika 84,6%; 3) kemampuan verbal dan membuat model matematika siswa berpengaruh secara signifikan terhadap kemampuan menyelesaikan soal cerita, dengan kemampuan verbal dan membuat model matematika sebesar 87,8%. Hal ini mengindikasikan bahwa peningkatan kemampuan siswa dalam menyelesaikan soal cerita matematika akan lebih optimal jika kemampuan verbal dan kemampuan membuat model matematika diperhatikan secara bersamaan dibandingkan hanya fokus pada salah satu kemampuan saja.
Kata kunci : Kemampuan verbal, Model matematika, Soal cerita, Kurikulum 2013
Los preámbulos fundacionales de la educación física escolar en el entorno español. Una mirada de los textos en educación del siglo XVIII = Beginnings of school physical education in Spain. Analysis of texts on education of the 18th century
Authors: Torrebadella Flix Xavier , Brasó Rius Jordi
Published: February 2021

En el reformismo de la Ilustración, la idealización de una educación pública fue la piedra angular para edificar la noción de un Estado-nación libre y soberano. El objetivo de estudio busca distinguir los preámbulos fundacionales de la educación física escolar que, se fundamentan desde la educación confesional del siglo XVII, y pasan a ser integrados en la emergente ideología liberal y a formar parte de los dispositivos de distinción y utilidad social en el siglo XVIII. La metodología se ha basado en un análisis hermenéutico a partir de las fuentes primarias de la época. Estos textos se refuerzan con fuentes secundarias que permiten dibujar este momento social. Los resultados permiten comprobar un uso instrumental de la educación física escolar, en favor del poder-económico-estatal.AbstractIn the reformism of 18th century, the idealization of a public education was the cornerstone for building the notion of a free and sovereign nation-state. The study objective analyzes the foundational beginnings of school physical education, which are based on confessional education (17th century), and become integrated into the emerging liberal ideology and become part of the devices of distinction and social utility (18th century). The methodology has been based on a hermeneutical analysis based on the primary sources of the time. These texts are accompanied by secondary works that allow us to draw this social moment. The results allow to verify an instrumental use of school physical education, in favor of the state-economic power.
Methodological problems of studying personal educational trajectories in pedagogical psychology
Authors: Gasanova R. R.
Published: February 2021

Modern education is actively changing and looking for directions for its development, work optimization, as well as ways to minimize the processes of destruction and degradation of university and secondary, cultural and professional, general and additional education.

The research objective is to comprehend the methodological problems of studying personal educational trajectories in educational psychology.

Research methodology. The work represents a theoretical understanding of the methodological problems of studying personal educational trajectories in pedagogical psychology. Our study develops the idea of the systematic understanding significance of methodological problems of studying personal educational trajectories in pedagogical psychology.

The study main results. Various aspects of the methodological problems of studying personal educational trajectories in pedagogical psychology are reflected in many works of domestic and foreign researchers. However, they are fragmented and do not meet the demands of modern practice with its constant changes. They do not meet many of the needs related to progressive innovations in the field of procedural and substantive dialogue, substantive and procedural individualization, orientation towards obtaining effective and necessary knowledge that help a person to become a cultural subject. They do not correspond to regressive returns to standardization formalism, the rejection of fundamental education and understanding a person of himself and the world in favor of functional fragmentation and commodification, which reduces education to the purchase of competencies and/or documents on the purchase of competencies. The educational space formation is the basis to create an individual educational trajectory for developing a person as an individual, partner and professional. Individual educational trajectories act as a condition for students' self-determination in the educational space. Making it possible to choose one's own educational trajectory is an essential component of the modern educational environment.

Conclusions. Both the standards of general and additional education, and the original educational and their support should be organized on clearly verified and transparent grounds, within the framework of models methodically and methodologically formulated and formed based on scientific ideas. It is necessary to take into account and minimize various risks of developing and implementing individual educational trajectories of students in educational organizations: the interaction of participants in educational relations.
Quality theorization and personality development technologization in the sport and educational environment
Authors: Pozharkin D. I. , Kazantseva N. A. , Kazantseva O. A.
Published: February 2021

The article defines the foundations for the processes of quality theorization and personality development technologization in the sports and educational environment. It clarifies the concepts of «theorization of quality for personality development in the sport and educational environment», «personality development technologization in the sport and educational environment» in the system of traditional pedagogy and pedagogical methodology (broad, narrow, local meanings), innovative pedagogy and pedagogical methodology (adaptive-productive, reproductive-productive, creative-productive meanings). The authors determine bases of dualistic understanding of the importance to create pedagogical conditions for quality management by personality development technologization in the sport and educational environment and to implement the ideas of integrity and universality in functioning and managing the sport and educational environment. They specify the possibilities to set and solve the problems of quality theorization and personality development technologization in the sport and educational environment through revealing functions, principles, models, technologies of theorizing quality and personality development technologization in the sport and educational environment, pedagogical conditions for quality management, personality development technologization in the sport and educational environment, theorizing the basis of integrity and universality in functioning and managing the sport and educational environment.
Problems of information and psychological analysis confrontations in the logic of metamodern psychology
Authors: Sobolnikov V. V.
Published: February 2021

The analysis of the phenomenon of «information-psychological confrontation» as a direction of scientific research and practical activities of subjects in the realities of the metamodern of the XXI century is presented. The transformation of the world community, the development of technologies, AI, databases, biotechnologies (BEGEN), their complex application for destructive purposes have exposed new threats. The aim of the work was the theoretical substantiation of the phenomenon of «information-psychological confrontation » in the logic of the methodology of the psychology of the metamodern, and the refinement of the conceptual elements of the probabilistic model of the selection of technologies. The research methodology and methodology includes a system-activity approach and principles: virtuality, interactivity, digitality and oscillation. Associated activities within the confrontation have become a single genetic basis for its deployment. The general scientific method of cognition, included a theoretical and methodological analysis of sources, generalization, analysis, comparison. Systematization provided the flow of empirical and theoretical data using the methods of discourse and comparative analysis. In order to interpret paradigmatic texts, the techniques of hermeneutics, methods of metamodern psychology and political psychology were extracted. As a result of the analysis of the Anglo-Saxon model of confrontation, the essence is revealed, the methodology is refined, the author's edition of the definition is introduced. Analysis of promising technologies, problems of hybridization of confrontation, stages of their development, have determined the range of issues of psychological science to counter threats and challenges. The promising technologies of confrontation and the conceptual elements of the probabilistic model of their selection have been substantiated. It is based on the principle of oscillation with its mechanism for eliminating rigid structures and introducing conceptual diversity through flexible tools. In conditions of aggravated geopolitical rivalry, an adequate analysis and reaction of power structures is in demand. The development of theoretical foundations and bringing the confrontation system to a new level becomes relevant and is a novelty. In conclusion, the direction of further scientific research of various aspects of information and psychological confrontation was determined.
Psychological analysis of the relationship of monetary installations and strategies of a person financial behavior
Authors: Shperlin A. V. , Plotnikov S. G. , Mayborodina N. V.
Published: February 2021

The article presents study results of the relationship between monetary attitudes and strategies of a person's financial behavior. Factor analysis of the questionnaire by L. P. Tang «Money Ethic Scale» (MES) carried out on the Russian sample allowed identifying 5 agreed factors characterizing the respondent monetary attitudes: «Good», «Freedom», «Power», «Evil», «Budget». The structure of attitudes includes affective, cognitive, and behavioral components. The study reveales that Russian respondents are characterized by a contradictory and extremely emotional attitude towards money: along with the predominance of monetary values and attitude towards money as a supreme good and a symbol of freedom, at the same time there is a perception of money as an absolute evil, and a conviction of their harm to human life. The data obtained in the study indicate the prevalence of consumer, savings and debt models of financial behavior among the respondents, which can be explained by the peculiarities of the respondents' monetary attitudes among other things. The study results indicate the presence of a relationship between monetary attitudes and strategies of financial behavior, low efficiency of these strategies determined by the super emotional and irrational attitude towards money dominated in the modern Russian society. Prospects for further research are the analysis of the whole complex of factor, including individual-psychological characteristics influencing people's attitude to the material conditions of their own life and the choice of behavioral strategies in the economic sphere of life. In addition, the authors believe that to develop training and correctional programs contributed to raising the level of financial literacy, forming a rational attitude towards money, constructive strategies for financial behavior and effective economic and psychological adaptation of people in modern socio-economic conditions are promising and of practical importance.
Determinants of public mood in ethnic environment (a case of the Republic of Tyva)
Authors: Badarchi K. B. , Tovuu N. O.
Published: February 2021

The article examines features of the public attitude formation and dynamics in the ethnic environment in the context of influencing economic and socio-cultural factors. There is a paradox of stabilization (stagnation) of the population social and socio-political activity at the background of worsening socio-economic conditions in the residence region, which is clearly manifested in the ethnic periphery conditions. The Republic of Tyva and the indigenous ethnic group (Tuvinians) are studied as a model region. The authors associate the existing paradox with the loss of a subjectivity sense by representatives of a small ethnic group related to issues of general regional social significance and, on the contrary, a significance sense of family ties as a source of safety and well-being in ordinary life. The importance of family ties determines the high potential of cohesion with the secondary importance of the subject of joint (social) action. This is a positive resource from the point of the manageability of an ethnic society as an object of management, in particular, preserving socio-political stability in the region. At the same time, it is obvious that the visible manifestations of public sentiment do not correspond to the real situation in the economy and social sphere. Public apathy can cause declining or deteriorating the regional socio-economic situation, socio-political instability, and other cataclysms in the future. This issue requires deep analysis, discussion and timely resolution to prevent negative consequences, on the contrary, harmonize the development of our multinational country in the future.
A Diagnostic Algorithm Based on a Simple Clinical Prediction Rule for the Diagnosis of Cranial Giant Cell Arteritis
Authors: Czihal Michael , Lottspeich Christian , Bernau Christoph , Henke Theresa , Prearo Ilaria , Mackert Marc , Priglinger Siegfried , Dechant Claudia , Schulze-Koops Hendrik , Hoffmann Ulrich
Published: February 2021

Background: Risk tratification based on pre-test probability may improve the diagnostic accuracy of temporal artery high-resolution compression sonography (hrTCS) in the diagnostic workup of cranial giant cell arteriitis (cGCA). Methods: A logistic regression model with candidate items was derived from a cohort of patients with suspected cGCA (n = 87). The diagnostic accuracy of the model was tested in the derivation cohort and in an independent validation cohort (n = 114) by receiver operator characteristics (ROC)-analysis. The clinical items were composed to a clinical prediction rule, integrated into a stepwise diagnostic algorithm together with CRP-values and hrTCS-values. Results: The model consisted of 4 clinical variables (age > 70, headache, jaw claudication, anterior ischemic optic neuropathy). The diagnostic accuracy of the model for discrimination of patients with and without a final clinical diagnosis of cGCA was excellent in both cohorts (AUC 0.96 and AUC 0.92, respectively). The diagnostic algorithm improved the positive predictive value of hrCTS substantially. Within the algorithm, 32.8% of patients (derivation cohort) and 49.1% (validation cohort) would not have been tested by hrtCS. None of these patients had a final diagnosis of cGCA. Conclusion: A diagnostic algorithm based on a clinical prediction rule improves the diagnostic accuracy of hrTCS.
Computational Analysis Reveals a Critical Point Mutation in the N-Terminal Region of the Signaling Lymphocytic Activation Molecule Responsible for the Cross-Species Infection with Canine Distemper Virus
Authors: Yamamoto Yuta , Nakano Shogo , Seki Fumio , Shigeta Yasuteru , Ito Sohei , Tokiwa Hiroaki , Takeda Makoto
Published: February 2021

Infection of hosts by morbilliviruses is facilitated by the interaction between viral hemagglutinin (H-protein) and the signaling lymphocytic activation molecule (SLAM). Recently, the functional importance of the N-terminal region of human SLAM as a measles virus receptor was demonstrated. However, the functional roles of this region in the infection process by other morbilliviruses and host range determination remain unknown partly because this region is highly flexible, which has hampered accurate structure determination of this region by X-ray crystallography. In this study, we analyzed the interaction between the H-protein from canine distemper virus (CDV-H) and SLAMs by a computational chemistry approach. Molecular dynamics simulations and fragment molecular orbital analysis demonstrated that the unique His28 in the N-terminal region of SLAM from Macaca is a key determinant that enables formation of a stable interaction with CDV-H, providing a basis for CDV infection in Macaca. The computational chemistry approach presented should enable determination of molecular interactions involving regions of proteins that are difficult to predict from crystal structures because of their high flexibility.
CRISPR/dCas9-based Systems: Mechanisms and Applications in Plant Sciences
Authors: Karlson Chou Khai Soong , Mohd Noor Siti Nurfadhlina , Nolte Nadja , Tan Boon Chin
Published: February 2021

RNA-guided genomic transcriptional regulation tools, namely Clustered Regularly Interspaced Short Palindromic Repeats interference (CRISPRi) and CRISPR-mediated gene activation (CRISPRa), are a powerful technology for the field of functional genomics. Deriving from the CRISPR/Cas9 system, both systems comprise a catalytically dead Cas9 (dCas9) and a single guide RNA (sgRNA). This type of dCas9 is incapable of cleaving DNA but retains its ability to specifically bind to DNA. The binding of the dCas9/sgRNA complex to a target gene results in transcriptional interference. The CRISPR/dCas9 system has been explored as a tool for transcriptional modulation and genome imaging. Despite its potential applications and benefits, the challenges and limitations faced by the CRISPR/dCas9 system include the off-target effects, PAM sequence requirement, efficient delivery methods, and the CRISPR/dCas9-interfered crops being labeled as genetically modified organisms in several countries. This review highlights the progression of CRISPR/dCas9 technology as well as its applications and potential challenges in crop improvement.
Sustainable Agri-Food Processes and Circular Pathways in a Life Cycle Perspectives: Where Is Applicative Research Going?
Authors: Stillitano Teodora , Spada Emanuele , Iofrida Nathalie , Falcone Giacomo , De Luca Anna Irene
Published: February 2021

This study aims at providing a systematic and critical review on the state-of-the-art of life cycle applications from the circular economy point of view. In particular, the main objective is to un-derstand how researchers adapt life cycle approaches for the measurement of the empirical cir-cular pathways of agri-food systems along the overall lifespan. To perform the literature review, PRISMA protocol was considered to conduct a review by qualitative synthesis. Specifically, an evaluation matrix has been set up to gather and synthesize research evidence, by classifying pa-pers according to several integrated criteria. The literature search was carried out employing scientiﬁc databases. Findings evidence that the most common circularity topics are about closed-loop production systems, i.e. nutrient recovery for agricultural purposes, production of renewable energy, valorization of residues and wastes as fertilizers, food waste, and agro-wastes recycling for agriculture. To evaluate the benefits/impacts of CE strategies, Life Cycle Assess-ment (LCA) proved to be the most common methodology applied by authors, as it can help to meet the main CE requirements slowing and closing resource loops.
"It is Like Medicine": Using Sports to Promote Adult Women's Health in Rural Kenya
Authors: Barchi Francis , AbiNader Millan A. , Winter Samantha C. , Obara Lena M. , Mbogo Daniel , Thomas Bendettah M. , Ammerman Brittany
Published: February 2021

Despite the well-documented health benefits of recreational sports, few opportunities exist in lower- and middle-income countries for adult women to participate in recreational physical activities. An explanatory sequential mixed methods approach was used to explore associations between an innovative soccer program for adult women and self-reported health status. Cross-sectional survey data were collected in 2018-2019 from 702 women in the Nikumbuke Project, a health and literacy program in southeastern rural Kenya, followed by focus group discussions with 225 women who also participated in the Project's soccer program. Quantitative findings suggest that women who participated in soccer had 67% greater odds of reporting good or excellent health than their non-soccer playing peers. Thematic analysis of qualitative data indicated that women credited soccer with less pain, fatigue, and stress, as well as weight loss and reduced dependence on medicine for hypertension, pain, and sleep problems. Women equated health benefits with greater ease and efficiency in completing chores, reduced worries, youthful energy, male-like strength, and pleased husbands. Soccer programs for adult women may be particularly effective interventions in settings where access to health care is limited and where lack of opportunity to engage in physical aerobic activity increases women's risks for poor health outcomes. .
Local and Global Stability Analysis for Gilpin-Ayala Competition Model Involved in Harmful Species Via LMI Approach and Variational Methods
Authors: Rao Ruofeng
Published: February 2021

In this paper, stability of reaction-diffusion Gilpin-Ayala competition model with Dirichlet boundary value, involved in harmful species, was investigated. Employing Mountain Pass Lemma and linear approximation principle results in the local stability criterion of the null solution of the ecosystem which owns at least three stationary solutions. On the other hand, globally asymptotical stability criterion for the null solution of the ecosystem was derived by variational methods and LMI approach. It is worth mentioning that the stability criteria of null solution presented some useful hints on how to eliminate pests and bacteria. Finally, two numerical examples show the effectiveness of the proposed methods.
Network Protein Interaction in the Link between Stroke and Periodontitis Interplay: A Pilot Bioinformatic Analysis
Authors: Leira Yago , Mascarenhas Paulo , Blanco Juan , Sobrino Tomás , Mendes José João , Machado Vanessa , Botelho João
Published: February 2021

The clinical interaction between stroke and periodontitis has been consistently studied and confirmed. Hence, forecasting potentially new protein interactions in this association using bioinformatic strategies presents potential interest. In this exploratory study, we conducted a protein-protein network interaction (PPI) search with documented encoded proteins for both stroke and periodontitis. Genes of interest were collected via GWAS database. The STRING database was used to predict the PPI networks, first in a sensitivity purpose (confidence cut-off of 0.7), and then with a highest confidence cut-off (0.9). Genes over-representation was inspected in the final network. As a result, we foresee a prospective protein network of interaction between stroke and periodontitis. Inflammation, pro-coagulant/pro-thrombotic state and ultimately atheroma plaque rupture is the main biological mechanism derived from the network. These pilot results may pave the way to future molecular and therapeutic studies to further comprehend the mechanisms between these two conditions.
Assessment of Climate Indices and NDWI Analysis in Lerma Chapala Basin
Authors: Castro-Lazcarro Miriam , Davydova-Belitskaya Valentina , Cárdenas-Tristán Abraham
Published: February 2021

Lake Chapala is a natural ecosystem of Mexico, declared Ramsar site, currently, is an area with importance in the agricultural sector, tourism, and important source of drinking water in the Metropolitan area of Guadalajara, considered as a thermo regulatory body. This study used tools such as Rhtest, as well as analyzing extreme climate indices using RClimdex. In addition, the relationship with the change in water surface of Lake Chapala was assessed through the NDWI index, using Landsat images, between 1985 and 2018. According to the obtained results, the signs of climatic variability are detected in the study region, which, directly affects the basin runoff and water levels in the lake, as well as, the factor of water overexploitation in the basin, so it is considered that the lake conditions mostly depend on the type of management that is given to the resource. Finally, the results will help the understanding of climate variability and its water resources influence of the Lerma Chapala basin, which will assist in future research.
The Impact of Feedback Information on Dynamics Performance of Production-Inventory Control Systems
Authors: AL-Khazraji Huthaifa , Cole Colin , Guo William
Published: February 2021

The aim of this paper is to examine the beneficial impact of feedback information in the dynamics of production-inventory control systems. Two production-inventory control system models are analyzed: APIOBPCS and 2APIOBPCS models. The simulation-based experiment designs were conducted by using the state-space equations of the two models. The bullwhip effect as measured by the variance ratio between the order rate and the consumption rate, and inventory responsiveness as measured by the Integral of Absolute Error between the actual and the target levels of inventory, are two metrics used to evaluate the performance of the production-inventory control system in response to a random customer demand. To ensure that both models work under optimal performance, multi-objective particle swarm optimization (MOPSO) is employed to address the problem of tuning the controller’s parameters. The simulation results show the 2APIOBPCS model outperforms the APIOBPCS model at achieving the desired bullwhip effect and being able to provide better inventory responsiveness. The improvement in the inventory responsiveness becomes more significant when the system operates under mismatched lead time and/or an initial condition.
Online Identity Theft, Security Issues, and Reputational Damage
Authors: A/P Sinnathamby Sehgar Sopna , Zukarnain Zuriati Ahmad
Published: February 2021

Online identity-based theft is known to be one of the most serious and growing threats to victims, such as individuals and organizations, over the last 10 years due to the enormous economic damage these crimes have caused. The availability of personal information on the Internet has increased the chances of this cyber-crime. Online identity theft crime is the result of a combination of cyber-crimes on the one hand and lack of awareness and training of users on the other hand to protect personal data on the other. Education and awareness, which also contributes to early detection, is the strongest tool for consumers to safeguard themselves from online identity fraud. This paper provides a comprehensive explanation of online identity theft, the various approaches that thieves use to attack individuals and organizations and the types of fraud involved in this cyber-crime. The aim of this research is to evaluate the need for a reformulation of the concept of identity theft in order to be compatible with the evolution of behaviors and fraud.
INTERNAL AND EXTERNAL DETERMINANTS OF HOUSING PRICE BOOM IN HONG KONG
Authors: Taghizadeh-Hesary Farhad , Yoshino Naoyuki , Mortha Aline , Chiu Alvin , Naderi Niki
Published: February 2021

Hong Kong’s housing market witnessed a dramatic housing price appreciation in recent years, with the price index for private domestic housing units being three times higher than ten years ago. This trend is supported by both internal and external factors, as illustrated in this paper. By developing a theoretical model and an empirical analysis on the key variables influencing housing prices using monthly data from 1999 to 2018, we find that the main drivers of housing price appreciation are from the demand side and include income level, money supply and inflation. The main contribution of this study is the quantification of the role of Mainland China’s macroeconomic factors in housing price booms in Hong Kong. Our study shows that capital inflow from and inflation and recessions in Mainland China contribute to increasing housing prices in Hong Kong because the city’s real estate is seen as a way to preserve asset value. These findings call for the need for control of capital inflow between the two economies as well as for stricter regulations against empty houses in Hong Kong.
BLOCKCHAIN FUTURES IN CRYPTOCURRENCIES, TRADE AND FINANCE: A PRELIMINARY ASSESSMENT
Authors: Aysan Ahmet Faruk , Sadriu Behar , Topuz Humeyra
Published: February 2021

The study explores whether blockchain technology can change the paradigm of the current financial structure and the balance of power in the international financial system. Accordingly, this study reviews the development of blockchain technology by analyzing China and Venezuela, both of which struggle to harness their technological advancement and to enhance their power in the international realm. We found that Venezuela invests in blockchain technology to create an alternative payment structure for survivability, while China’s desire is to become a global leader in global blockchain technology.
THE NEXUS AMONG EMPLOYMENT, PRODUCTIVITY AND TRADE OPENNESS: EVIDENCE FROM BRICS AND INDONESIA
Authors: Rath Badri Narayan , Ridhwan Masagus M.
Published: February 2021

This paper investigates the nexus among employment, labor productivity and trade openness in Brazil, Russia, India, China, South Africa (BRICS), and Indonesia using annual data (1991–2018). The results suggest a long-run relationship among the variables but only in the agricultural sector of these economies. We also find a unidirectional causality running from employment to productivity in only the agricultural sector. Similarly, trade openness also Granger causes employment. Our final result indicates that trade openness positively influences labor productivity in the long-run. From a policy perspective, it is imperative for BRICS and Indonesia to target employment generation by promoting trade openness.
DRIVERS OF ILLIQUIDITY IN THE ASEAN SOVEREIGN BOND MARKET
Authors: Kinateder Harald , Bauer Robert , Wagner Niklas
Published: February 2021

We study illiquidity in ASEAN-5 sovereign bond markets from 2008 to 2019 by using an illiquidity measure, which is based on a proxy of the amount of arbitrage capital available in sovereign bond markets. Our analysis identifies three drivers of illiquidity in Singapore, namely economic policy uncertainty, the default spread and the GDP growth rate. In contrast, liquidity of all other markets is mostly not characterized by economic drivers. It appears that overall liquidity is lower in the markets outside Singapore and therefore deviations in these yield curves are higher on average and arbitrage eliminates larger deviations not immediately but in a delayed manner.
El asesino como el ‘doppelgänger’ de la ‘Final Girl’
Authors: Ganga Algarra José
Published: February 2021

Como apunta Freud en su texto “Lo ominoso”, la cuestión de lo siniestro puede partir de complejos infantiles reprimidos y suele estar vinculado a la propia imagen, al reflejo. Este artículo se propone indagar en el componente ominoso freudiano de la figura de Gosthface, el asesino enmascarado de Scream, slasher de terror adolescente y de masas dirigido por el autor estadounidense Wes Craven. Para ello, hemos indagado en la construcción del personaje de Sidney Prescott, la Final Girl –término creado por Carol Clover– de la saga, la superviviente última y la única heroína que es capaz de hacer frente al psicópata. Analizando la última secuencia de la película, en la que se resuelve la identidad del asesino, desde una perspectiva psicoanalítica y de género, indagaremos en las consecuencias que la confluencia entre la identidad, siempre plástica, del psicópata y la de la protagonista del relato tienen en la construcción de la identidad femenina desde los años noventa.
El Atragantamiento en el cine de Pedro Almodóvar. Análisis de Dolor y Gloria
Authors:   Universidad Complutense de Madrid, Hernández Martínez Eva
Published: February 2021

El presente trabajo propone un análisis de varios fragmentos de Dolor y Gloria (Almodóvar, 2019) con la metodología del análisis textual a fin de deletrear lo referido al síntoma mayor del personaje: el atragantamiento. Este trabajo pretende dar cuenta del carácter regresivo del film y su relación con los numerosos flashbacks (en total, más de un 30% del metraje). El cuerpo del protagonista aparece convertido en síntoma, incapacitándole para amar y trabajar. A lo largo del análisis se estudia la conflictiva del protagonista para desear y sus esfuerzos para elaborar la muerte de la madre. Se traza una comparativa entre Bringing up Baby (Howard Hawks, 1938) y Dolor y Gloria a partir del análisis de la primera propuesto por González Requena donde explica la utilización de dos operadores textuales recurrentes en la filmografía almodovariana: el hueso y el tigre. El punto de llegada será el deletreo del primer deseo de Salvador Mallo, alter ego del director, Pedro Almodóvar. La principal aportación consiste en la identificación de cierto atragantamiento de lo femenino y lo materno en los personajes masculinos de la filmografía de Almodóvar; más concretamente, en el film Dolor y Gloria.
Repercusión y difusión social de la posverdad y fake news en entornos virtuales
Authors:   Universidad Antonio de Nebrija, uárez Escribano Beatriz
Published: February 2021

Los seres humanos han tratado de agarrarse a identidades monolíticas que cree seguras como las determinadas por ideas políticas, religiosas o culturales desde siempre. Este fondo tiene mucho que ver con el deseo de aceptación social y la necesidad de elegir entre inabarcables opciones. La posverdad y las fake news han complicado esta situación, ya que modifican nuestra conducta utilizando diferentes dimensiones lingüísticas, llegando a crear mentiras, rumores y todo tipo de especulaciones. El objetivo de esta investigación consiste en determinar el nivel de veracidad que damos a las noticias, y si esta es directamente proporcional al número de votos (o me gusta) que tengan. A través de una revisión bibliográfica documental de diferentes mensajes encontrados en redes sociales, se evidencia nuestra renuncia a la verdad debido a las escasas competencias digitales que tenemos. Los resultados demuestran que nuestro comportamiento digital se ha visto modificado, ya que cada vez son menos las personas que contrastan la información que reciben, provocando que estas noticias falsas se propaguen mucho más rápido.
Structural brain network characteristics in patients with episodic and chronic migraine
Authors: Michels Lars , Koirala Nabin , Groppa Sergiu , Luechinger Roger , Gantenbein Andreas R , Sandor Peter S , Kollias Spyros , Riederer Franz , Muthuraman Muthuraman
Published: February 2021

Background: Migraine is a primary headache disorder that can be classified into an episodic (EM) and a chronic form (CM). Network analysis within the graph-theoretical framework based on connectivity patterns provides an approach to observe large-scale structural integrity. We test the hypothesis that migraineurs are characterized by a segregated network. Methods: 19 healthy controls (HC), 17 EM patients and 12 CM patients were included. Cortical thickness and subcortical volumes were computed, and topology was analyzed using a graph theory analytical framework and network-based statistics. We further used support vector machines regression (SVR) to identify whether these network measures were able to predict clinical parameters. Results: Network based statistics revealed significantly lower interregional connectivity strength between anatomical compartments including the fronto-temporal, parietal and visual areas in EM and CM when compared to HC. Higher assortativity was seen in both patients’ group, with higher modularity for CM and higher transitivity for EM compared to HC. For subcortical networks, higher assortativity and transitivity were observed for both patients’ group with higher modularity for CM. SVR revealed that network measures could robustly predict clinical parameters for migraineurs. Conclusion: We found global network disruption for EM and CM indicated by highly segregated network in migraine patients compared to HC. Higher modularity but lower clustering coefficient in CM is suggestive of more segregation in this group compared to EM. The presence of a segregated network could be a sign of maladaptive reorganization of headache related brain circuits, leading to migraine attacks or secondary alterations to pain.
A novel clinical model for predicting malignancy of solitary pulmonary nodules: A multicenter study in Chinese population
Authors: He Xia , Xue Ning , Liu Xiaohua , Tang Xuemiao , Peng Songguo , Qu Yuanye , Jiang Lina , Xu Qingxia , Liu Wanli , Chen Shulin
Published: February 2021

Background: This study aimed to establish and validate a novel clinical model to differentiate between benign and malignant solitary pulmonary nodules (SPNs). Methods: Records from 295 patients with SPNs in Sun Yat-sen University Cancer Center were retrospectively reviewed. The novel prediction model was established using LASSO logistic regression analysis by integrating clinical features, radiologic characteristics and laboratory test data, the calibration of model was analyzed using the Hosmer-Lemeshow test (HL test). Subsequently, the model was compared with PKUPH, Shanghai and Mayo models using receiver-operating characteristics curve (ROC), decision curve analysis (DCA), net reclassification improvement index (NRI), and integrated discrimination improvement index (IDI) with the same data. Other 101 SPNs patients in Henan Tumor Hospital were used for external validation cohort.Results: A total of 11 variables were screened out and then aggregated to generate new prediction model. The model showed good calibration with the HL test (P = 0.964). The AUC for our model was 0.768, which was higher than other three reported models. DCA also showed our model was superior to the other three reported models. In our model, sensitivity = 78.84%, specificity = 61.32%. Compared with the PKUPH, Shanghai and Mayo models, the NRI of our model increased by 0.177, 0.127, and 0.396 respectively, and the IDI changed -0.019, -0.076, and 0.112, respectively. Furthermore, the model was significant positive correlation with PKUPH, Shanghai and Mayo models.Conclusions: The novel model in our study had a high clinical value in diagnose of MSPNs.
Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer’s disease: a Mendelian randomization study
Authors: Ou Ya-Nan , Yang Yu-Xiang , Shen Xue-Ning , Ma Ya-Hui , Chen Shi-Dong , Dong Qiang , Tan Lan , Yu Jin-Tai
Published: February 2021

Background: Observational studies suggest that the use of antihypertensive medications (AHMs) is associated with a reduced risk of Alzheimer’s disease (AD); however, these findings may be biased by confounding and reverse causality. We aimed to explore the effects of blood pressure (BP) and lowering systolic BP (SBP) via the protein targets of different AHMs on AD through a two-sample Mendelian randomization (MR) approach. Methods: Genetic proxies from genome-wide association studies of BP traits and BP-lowering variants in genes encoding AHM targets were extracted. Estimates were calculated by inverse-variance weighted method as the main model. MR Egger regression and leave-one-out analysis were performed to identify potential violations. Results: There was limited evidence that genetically predicted SBP/diastolic BP level affected AD risk based on 400/398 single nucleotide polymorphisms (SNPs), respectively (all P>0.05). Suitable genetic variants for β-blockers (1 SNP), angiotensin receptor blockers (1 SNP), calcium channel blockers (CCBs, 45 SNPs) and thiazide diuretics (5 SNPs) were identified. Genetic proxies for CCB [odds ratio (OR)=0.959, 95% confidence interval (CI)=0.941-0.977, P=3.92×10-6], and overall use of AHMs (OR=0.961, 95% CI=0.944-0.978, P=5.74×10-6, SNPs=52) were associated with a lower risk of AD. No notable heterogeneity and directional pleiotropy were identified (all P>0.05). Additional analyses partly support these results. No single SNP was driving the observed effects. Conclusions: This MR analysis found evidence that genetically determined lowering BP was associated with a lower risk of AD and CCB was identified as a promising strategy for AD prevention.