bluuebunny/crossref_metadata_2025 huggingface dataset:
A novel Prognostic Model for Overall Survival in Patients with melanoma
Authors: Li Wenbo , Yang Dan , Ju Linjun , Chen Zheng , Lei Haike , Wu Zhongjun , Xiang Tingxiu
Published: November 2023

Objective
The objective of this research was to develop and validate a novel prognostic model for predicting overall survival (OS) in patients diagnosed with melanoma.
Methods
Based on data (n = 752) from patients diagnosed with melanoma between January 2017 and December 2020 in Chongqing University Cancer Hospital in China, we randomly divided them into two cohorts: a training cohort (n = 527) and a validation cohort (n = 225) in a 7:3 ratio. We conducted logistic univariable and multivariable analysis to identify independent risk factors for OS in melanoma patients, which were then integrated into a nomogram. The nomogram was internally validated to ensure its reliabitly. The predictive effectiveness of the nomogram was assessed using receiver operating characteristic (ROC) and calibration curve. Decision curve analysis (DCA) curves were also utilized to evaluate the model’ prediction ability.
Results
A total of 752 melanoma patients were included in the analysis. The nomogram incorporated seven independent risk factors for melanoma patients, including age, basic-disease, surgery, tumor node metastasis (TNM), chemotherapy, interleukin2, lactate-dehydrogenase (LDH). The C-indices for OS to predict the 1-, 3-, and 5- years survival retes were 0.704 (0.643–0.766),0.742 (0.685–0.799),0.740 (0.663–0.817) in the training cohort, and 0.733 (0.647–0.818),0.714 (0.624–0.803),0.710 (0.591–0.830) in the validation cohort, respectively. The calibration curve showed a strong agreement between nomogram and actual observations for the probability of survival in both the training and validation cohorts. The calibration plots and DCA of the nomogram demonstrated excellent concordance between the predicted and actual probabilities.
Conclusions
We developed and validated a predictive nomogram for OS in melanoma patients. This nomogram provided a reliable and user-friendly approach to forecast the survival outcomes of individuals with melanoma. The application of this innovative model has the potential to facilitate personalized early detection and treatment strategies, thereby benefiting patients with melanoma.
Zinc oxide doping graphene oxide composites by brush coating for uniformly one-side formation thin films
Authors: Oh Jin Young , Yang Da-Bin , Lee Dong Wook , Jeong Hae-Chang , Seo Dae-Shik
Published: November 2023

We investigated the alignment properties of liquid crystals (LC) on a brush-coated composite film made of graphene oxide and zinc oxide (GO-ZnO). The GO-ZnO composites were prepared using a sol-gel solution process, and the resulting solution was brush-coated onto indium tin oxide (ITO) glass. During the annealing process, an anisotropic roughened surface was created; however, the crystallinity analysis of GO-ZnO indicated that the brushed coating did not affect the crystalline structure significantly. The LC molecules exhibited stable alignment characteristics owing to the aligned surface roughness and hydrophilic properties of GO-ZnO, resulting in a homogeneously aligned structure. Residual DC measurements showed similar levels as the conventional rubbed polyimide cells, and a switching voltage of 1.7 V was observed. Brush coating is a cost-effective and simple deposition/alignment process, making it crucial in terms of cost-efficiency and process simplicity.
Optical and electronic properties of pyrite
Authors: Nzulu Gabriel , Magnusson Martin , Mgnusson Roger
Published: November 2023

The optical and electronic properties of pyrite (FeS2) mineral have been investigated by ex-situ spectroscopic ellipsometry measurements made on pristine (bulk) FeS2. This method offers an alternative to petrographic microscopes used in many laboratories, as well as, in education and research institutions to study optical properties of rocks and minerals. The ability of spectroscopic ellipsometry to determine the dielectric function {ε (E) = ε1 (E) + iε2 (E)} of the material from its structural morphology, band gap, and electrical conductivity within the infrared spectral range (0.73–5.9 eV) is an added advantage over the optical microscopy that require ample time for thin section sample preparation to enable an optical light beam to be transmitted or reflected. As shown in this work, petrographic analyses of rocks and minerals using spectroscopic ellipsometry is a useful technique for optical studies of rocks and minerals with an added advantage over petrographic microscopy (optical microscopy).
Coreopsis grandiflora × lanceolata auf dem Schwemmfächer des Muldedurchbruchs bei Pouch (Landkreise Anhalt-Bitterfeld und Nordsachsen)
Authors: Krumbiegel Anselm , Weiss Volkmar
Published: November 2023

Seit 2018 tritt Coreopsis in zunehmendem Umfang auf dem Schwemmsandfächer des Muldedurchbruches von 2013 in den Seelhausener See zwischen Pouch und Löbnitz auf. Mitteilungen über Vorkommen von Coreopsis lanceolata existieren seit 2002 vereinzelt aus Sachsen-Anhalt und seit 1998 aus Sachsen, vor allem aus der Lausitz und auch von C. grandiflora. Die Bestimmung der Exemplare vom Muldedurchbruch erwies sich vielfach als problematisch, weil an zahlreichen Individuen sowohl Merkmale von C. lanceolata als auch C. grandiflora auftreten. Dies überrascht insofern nicht, als Coreopsis züchterisch für den Gartenbau bearbeitet wurde, um erwünschte Eigenschaften unterschiedlicher Arten in einer Sippe zu vereinigen. In den Folgegenerationen mendeln die Eigenschaften aus. Es wird ein Überblick über die bestimmungsrelevanten Merkmale aus der Literatur gegeben und die Verteilung der Merkmale bei den untersuchten Individuen vom Muldedurchbruch sowie im Vergleich dazu von einer Population aus Sandersdorf bei Bitterfeld und vom Bahnhof Leipzig-Leutzsch. Meist überwiegen die Merkmale von C. lanceolata, oft in Kombination mit solchen von C. grandiflora. Soziologisch lässt sich die Begleitvegetation von Coreopsis auf dem Schwemmfächer der Mulde dem Verband Corynephorion zuordnen. Dieser Standort entspricht, wie auch die aus der Literatur für Sachsen-Anhalt und Sachsen angegebenen, denen im nordamerikanischen natürlichen Verbreitungsgebiet – offene, sandige, trockene Stellen. Es ist daher von einer weiteren Ausbreitung von Coreopsis an entsprechend geeigneten Stellen, wie sie z. B. großflächig in der Bitterfelder Bergbaufolgelandschaft vorhanden sind, zu rechnen. Eine Gefahr von invasivem Verhalten wird hier jedoch nicht gesehen, sondern vielmehr eine Bereicherung als attraktive Insektenweide.
Verwilderungen von Sorbus intermedia (EHRH.) PERS. im Raum Salzwedel (Altmark)
Authors: Brennenstuhl Günter
Published: November 2023

Während einer mehrere Jahrzehnte umfassenden Beobachtungszeit konnten im Raum Salzwedel an 45 Fundorten, verteilt auf 10 Messtischblatt-Quadranten, Verwilderungen von Sorbus intermedia ermittelt werden. Die Fundorte werden mitgeteilt, Angaben zur Individuenzahl, zum Habitus und zur Beständigkeit vervollständigen die Aussagen. Die Herkunft der Verwilderungen wird an einigen Beispielen diskutiert.
Genus Asplenium L. im Altmarkkreis Salzwedel
Authors: Brennenstuhl Günter
Published: November 2023

Im Beobachtungsgebiet, das hauptsächlich den Altkreis Salzwedel umfasst, ist das Genus Asplenium L. mit den Arten A. ruta-muraria und A. trichomanes vertreten. Es werden ausschließlich Sekundärstandorte besiedelt. An einigen Fundorten konnte die Entwicklung der Populationen über mehrere Jahrzehnte verfolgt werden. Während der Beobachtungszeit (1967–2013) wurden von A. ruta-muraria 40 und von A. trichomanes lediglich 3 Vorkommen ermittelt, die 19 bzw. 3 Messtischblatt-Quadranten zuzuordnen sind. Durch die seit 1990 vermehrt durchgeführten Sanierungsmaßnahmen an Bauwerken sind etliche Vorkommen vernichtet bzw. ist deren Individuenzahl stark dezimiert worden. Die aktuelle Bestandssituation wird mitgeteilt.
Nachtrag zur Brombeerflora von Sachsen-Anhalt mit Nachbargebieten
Authors: Weber Heinrich E.
Published: November 2023

Drei neue Rubus-Arten (Haselblattbrombeeren) der Sektion werden beschrieben: Rubus tilioides W. JANSEN & H. E. WEBER mit Vorkommen vor allem in Thüringen, außerdem in Sachsen und Sachsen-Anhalt; R. anhaltianus H. E. WEBER (mittleres bis südwestliches Sachsen-Anhalt, angrenzendes Thüringen) und R. orbifrons H. E. WEBER (südwestliches Sachsen-Anhalt, ein Nachweis auch im angrenzenden Thüringen). Neu für Sachsen-Anhalt nachgewiesen wurde Rubus xiphophorus H. E. WEBER. Außerdem wurden weitere Fundorte für Rubus wahlbergii ARRH. bei Bergwitz und Helbra in Sachsen-Anhalt ermittelt. Die neuen Arten sind illustriert durch Fotos ihrer Holotypen und von lebenden Pflanzen im Gelände. Ihre Verbreitung wird durch Auflistung von Herbarbelegen und durch Rasterkarten mitgeteilt.
Chorispora tenella (PALL.) DC., Brassicaceae, ein Neubürger in der Flora von Sachsen-Anhalt
Authors: Kästner Arndt
Published: November 2023

Chorispora tenella (PALL.) DC. zählt zum Verwandtschaftskreis von Raphanus (Brassicaceae). Das Hauptverbreitungsgebiet liegt in Südosteuropa. In Deutschland kommt die Art bisher nur sehr selten vor. Neuerlich wurde ein weiterer Fund auch in Sachsen-Anhalt, Saalekreis nahe Halle festgestellt.
Über einen neuen Binnenlandnachweis von Cochlearia danica L. bei Pretzier (Altmark)
Authors: Brennenstuhl Günter
Published: November 2023

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Hierochloe odorata in der Fuhneniederung bei Radegast
Authors: Stolle Jens
Published: November 2023

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Bemerkenswerte Arten nach Straßenbaumaßnahmen in Salzwedel
Authors: Brennenstuhl Günter
Published: November 2023

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Fundorte bemerkenswerter Pflanzenarten in Sachsen-Anhalt
Authors: Ziesche Heinz
Published: November 2023

In diesem Beitrag werden Neufunde (bezogen auf die Rastereinheit Messtischblatt-Quadrant) ab dem Jahr 2000 sowie Wiederbestätigungen bemerkenswerter Farn- und Blütenpflanzen in Sachsen-Anhalt genannt, welche die Kenntnisse über die Verbreitung der Arten im Bundesland erweitern sowie mögliche Tendenzen andeuten. Die zeitlichen Angaben beziehen sich auf den Kenntnisstand des „Verbreitungsatlas der Farnund Blütenpflanzen Ostdeutschlands“ (BENKERT et al. 1996) sowie auf aktuelle Kartierungsmitteilungen.
Trifolium retusum in Sachsen-Anhalt: Verbreitung, Soziologie
Authors: John Heino , Korneck Dieter
Published: November 2023

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Banater Segge (Carex buekii W imm.) und das Caricetum buekii Kopecky et Hejny 1965 in Sachsen-Anhalt im Vergleich mit anderen Regionen Mitteleuropas
Authors: Warthemann Guido , Reichhoff Lutz
Published: November 2023

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Zum taxonomischen Rang zweier kritischer Sippen der Gattung Gagea in Mitteleuropa
Authors: John Heino , Peterson Angela , Peterson Jens
Published: November 2023

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Verbreitung, standortökologische Bindung und Populationsentwicklung der Natternzungengewächse (Ophioglossaceae) in ehemaligen Braunkohleabbaugebieten Sachsen-Anhalts
Authors: Tischew Sabine , Lebender Andreas
Published: November 2023

Am Beispiel der Bergbaufolgelandschaft Sachsen-Anhalts wird anhand eines Vergleiches von Verbreitungskarten gezeigt, dass anthropogene Sekundärstandorte zunehmend wichtige Ersatzlebensräume für das Vorkommen von Ophioglossaceen darstellen. Für die Arten Ophioglossum vulgatum (Gemeine Natternzunge), Botrychium lunaria (Mondrautenfarn) sowie Botrychium matricariifolium (Ästige Mondraute) werden die standörtliche Bindung und die Vergesellschaftung auf den Folgeflächen des Braunkohletagebaus gezeigt. Die Natternzungengewächse stellen typische Beispiele für naturschutzrelevante Arten dar, die nach dem Durchlaufen der Pionierphase auf den Kippenflächen in mittleren Sukzessionsstadien auftreten. Sie bevorzugen nährstoffarme, lichte Pionierwälder in Kombination mit krautschichtarmen Offenlandmosaiken. Infolge der relativ langsam verlaufenden Sukzessionsprozesse besteht vor allem auf Extremstandorten die Möglichkeit, ohne Pflegeaufwand langfristig geeignete Lebensräume für diese Arten zu erhalten. Die Ergebnisse von Untersuchungen auf Dauerbeobachtungsflächen zeigen, dass insbesondere die Populationen der Gemeinen Natternzunge starken Schwankungen in der Populationsdichte unterliegen. Auf den grundwasserfernen Standorten reagiert die Art sehr sensibel auf den Witterungsverlauf und bildet unterirdische Ruhestadien aus. Insgesamt sind die Konkurrenzsituation und das Entwicklungspotenzial für die Arten der Ophioglossaceen auf den meisten Standorten positiv zu bewerten. Eine wesentliche Grundlage für den Erhalt der Arten in der Bergbaufolgelandschaft im Sinne des Prozessschutzes sind die Ausweisung und der Schutz von möglichst ausgedehnten Sukzessionsflächen mit unterschiedlichen Entwicklungsstadien.
Beiträge zur Flora der Umgebung von Weißenfels
Authors: Herz Eckhard , Köhler Hans
Published: November 2023

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Floristische Neu- und Wiederfunde in der Fuhneaue im Saalkreis
Authors: Krumbiegel Anselm
Published: November 2023

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Populationsdynamik einiger Orchideenarten von Waldrandökotonen des Huy nach Pflegeeingriffen
Authors: Wegener Uwe , Eberspach Wolfgang
Published: November 2023

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Floristische Neu- und Wiederfunde in der Fuhneaue im Landkreis Bitterfeld
Authors: Krumbiegel Anselm
Published: November 2023

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Nomenklatorisch-taxonomische Änderungen in der 16. Auflage der von W. ROTHMALER begründeten Exkursionsflora von Deutschland
Authors: Braun Uwe
Published: November 2023

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Bemerkenswerte Funde aus Sachsen-Anhalt
Authors: Korsch Heiko
Published: November 2023

Die kleine Zusammenstellung enthält bemerkenswerte Neufunde und Bestätigungen ausden Jahren 1994-1997 aus Sachsen-Anhalt. Bis 1995 sind diese bereits in den Verbreitungsatlas der Farn- und Blütenpflanzen Ostdeutschlands eingegangen. Der größere Teilder Angaben stammt aus den von mir in den letzten beiden Jahren kartierten Meßtischblättern Ziegelroda (4634) und Querfurt (4635), der Rest aus fast ganz Sachsen-Anhalt.
Man sieht nur was man kennt – Drei Zwergwasserlinsen-Arten der Gattung Wolffia Schleid. in Sachsen-Anhalt nachgewiesen
Authors: Frank Dieter , Bog Manuela , Appenroth Klaus-Jürgen , Schmitz Ulf
Published: November 2023

Vorinformationen zum Vorkommen von Zwergwasserlinsen in Sachsen-Anhalt wurden geprüft. Hinweise zu Wolffia arrhiza Horkel ex Wimm. für den Drömling und das Flämingvorland wurden bestätigt. Die neophytischen Wolffia columbiana H. Karst. und Wolffia globosa (Roxb.) Hartog & Plas konnten im Elbetal nachgewiesen werden. Die Artzugehörigkeit wurde durch DNA-barcoding (Sequenzierung) des plastidären intergenischen Markers psbK-psbI bestätigt.
Bibliographie botanischer Literatur über Sachsen-Anhalt 2018 und Nachträge
Authors: Krumbiegel Anselm
Published: November 2023

Die Bibliographie zur botanischen Literatur über Sachsen-Anhalt wird mit Nachträgen und den bisher zugänglichen Publikationen und Abschlussarbeiten von 2018 fortgesetzt.
Bibliographie botanischer Literatur über Sachsen-Anhalt 2010/2011
Authors: Krumbiegel Anselm
Published: November 2023

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Nachtrag zu aktuellen Vorkommen bemerkenswerter Pflanzenarten in der Fuhneniederung des Saalkreises
Authors: Stolle Jens
Published: November 2023

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Zum Verhalten von mit Grassaat ausgebreiteten gebietsfremden Sippen entlang der Bahnstrecke Stendal-Uelzen
Authors: Brennenstuhl Günter
Published: November 2023

An der Bahnstrecke Stendal-Uelzen werden seit 1990 umfangreiche Bauarbeiten durchgeführt. Die dabei entstandenen Bodenverwundungen sind anschließend mit Grassaatmischungen wieder begrünt worden. Dadurch gelangten auch gebietsfremde Sippen zur Entfaltung, deren Populationsentwicklung an mehreren Wuchsorten verfolgt wurde. Aus dem Verhalten (Beständigkeit, Ausbreitung, Rückgang) von 12 in die Betrachtung einbezogenen Arten werden Rückschlüsse auf den im Beobachtungsgebiet erlangten floristischen Status gezogen.
Man sieht nur, was man kennt. Ficaria calthifolia Rchb. auf historisch altem Grünland
Authors: Frank Dieter
Published: November 2023

Eine bisher nicht erkannte heimische Scharbockskrautart, Ficaria calthifolia Rchb., wurde im Elbetal bei Pretzsch neu für Sachsen-Anhalt nachgewiesen. Da die Art nicht über Mechanismen zur aktiven Fernausbreitung verfügt, sondern räumlich-zeitlich kleine Nischen besiedelt (CSR-Strategie), ist Habitatkontinuität wichtig. In diesem Zusammenhang wird die Bedeutung von historisch altem Grünland diskutiert.
Verwilderungen von Amelanchier-Taxa in der Umgebung von Salzwedel (Altmark)
Authors: Brennenstuhl Günter
Published: November 2023

Die Fundortdaten der im Altmarkkreis Salzwedel nachgewiesenen Verwilderungen von Amelanchier alnifolia, A. lamarckii und A. spicata werden mitgeteilt. Angaben zu den Standortverhältnissen, zur Begleitflora und zum Populationsumfang ergänzen die Ausführungen. Außerdem wird auf wesentliche Unterscheidungsmerkmale der drei Arten eingegangen.
Genus Pulmonaria L. in der Umgebung von Salzwedel (Altmark)
Authors: Brennenstuhl Günter
Published: November 2023

Pulmonaria obscura ist die einzige Art des Genus Pulmonaria, die im Raum Salzwedel noch autochthone Vorkommen aufzuweisen hat. Hinzu kommen einige Verwilderungen der auch als Zierpflanze gezogenen P. officinalis s. str. Von beiden Arten werden die aktuellen Nachweisdaten mitgeteilt. Auf die Differenzierung des P. officinalis agg. und die Trennung von weiteren kultivierten Sippen wird eingegangen. Außerdem werden die historischen Aufzeichnungen über Vorkommen von P. angustifolia bei Salzwedel dargestellt. Angaben zur Bedeutung von P. officinalis s. str. in der Volksheilkunde vervollständigen die Ausführungen.
Aktuelle Situation der Park-Vorkommen von Fritillaria meleagris L. in Sachsen-Anhalt
Authors: Krumbiegel Anselm
Published: November 2023

Im Jahr 2016 wurden die drei Vorkommen von Fritillaria meleagris in Landschaftsparks in Sachsen-Anhalt erfasst und mit den Befunden aus dem Jahr 2010 verglichen.
Wiederfund von Lindernia procumbens am Bleddiner Dorfteich (Lkrs. Wittenberg)
Authors: Krumbiegel Anselm
Published: November 2023

Im Rahmen des Monitorings der Pflanzenarten des Anhangs IV der FFH-Richtlinie in Sachsen-Anhalt wurde Lindernia procumbens erstmals nach zwölf Jahren am letzten bekannten Fundort, dem Bleddiner Dorfteich, wiedergefunden. Der Nachweis unterstreicht die Notwendigkeit regelmäßiger Kontrollen des Fundortes, an dem trotz wiederholt günstig erscheinender Bedingungen die Art jahrelang nicht auftritt.
Aktuelle Situation einiger Vorkommen von Fritillaria meleagris in Sachsen-Anhalt
Authors: Krumbiegel Anselm
Published: November 2023

Zwischen 2011 und 2014 wurden die vier Vorkommen von Fritillaria meleagris L. außerhalb von Parkanlagen teils mehrfach aufgesucht und die Populationsgrößen ermittelt. Ergänzend zu den Erhebungen aus dem Jahr 2010 wurden am Fundort bei Salzwedel zusätzlich Vegetationsaufnahmen erstellt.
PROMISING RESEARCH ON ANTIVIRAL MEDICATIONS OFFERS NEW PROSPECTS FOR SARS-COV-2 RECOVERY
Authors:   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Gurram Anusha , Chagamreddy Bavitha ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Tumukunde Jessica ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Venkata Supraja Kurapati Lakshmi ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Sai Manoja Rasagna M. Sri ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Chowdary Chigurupati Druthima ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Pavani Doppalapudi ,   Department of Biotechnology, Koneru Lakshmaiah Education Foundation, Guntur, Andhra Pradesh, India., Singh Ranwas Reethika ,   Department of Molecular Biology, Cresent Biosciences, ICRAB Campus, Kanpur, Uttar Pradesh, India.
Published: November 2023

The ongoing COVID-19 pandemic has spurred extensive research efforts worldwide to identify effective treatments for SARS-CoV-2, the virus responsible for the disease. This study focusses on recent developments in antiviral medication research, showcasing the potential breakthroughs and novel approaches in the quest for SARS-CoV-2 recovery. From monoclonal antibodies to emerging antiviral drugs and vaccine advancements, this research landscape offers renewed hope for managing and ultimately defeating the virus. We summarize the key findings, promising prospects, and evolving strategies in the field of antiviral therapeutics, underscoring the collective efforts to combat the global pandemic.
ASSESSMENT OF SHIFT IN THE ANTIBIOTIC SUSCEPTIBILITY PATTERN OF AEROBIC BACTERIAL ISOLATES FROM MICROBIAL BIOFILMS IN PATIENTS WITH ORAL SQUAMOUS CELL CARCINOMA AND PRECANCEROUS CONDITIONS
Authors: Agarwal Aditi , Sharma Rajni , Sharma Kopal , Sharma Navya
Published: November 2023

Background: Antimicrobial resistance is a concerning global health problem in reference to cancer patients as they are more susceptible to drug-resistant microorganisms because of their immunocompromised states. Aim: The aim of this study was to study the changes in the pattern of aerobic bacterial flora in the patients of oral cancer and precancerous lesions and to identify the susceptibility to commonly used Antibiotics in clinical practice. Methods: This prospective observational study was carried out in a randomly selected cohort of oral cancer and precancerous patients being treated at tertiary care centre in Rajasthan, for a period of 1 year. Oral swabs were collected from patients presenting with oral cancer and precancerous lesions and subjected to microbiological examination for their colony characters, morphology on Gram stain as well for Antibiotic sensitivity patterns for commonly used drugs. Results: Of the 100 oral cancer patients, isolated bacterial colonies showed a mixture of Gram-Positive and Gram-Negative organisms. Staphylococcus species (nâ€‰= 15) were seen in high numbers in the case of Gram-positive organisms, while in Gram-negative bacteria Pseudomonas species (nâ€‰=â€‰45) increased in number. Among the precancerous patient group normal commensal (Micrococci, n= 24) was the predominant species. In Gram-negative bacteria, all were susceptible to Piperacillin Tazobactam and Imipenem while in Gram-positive bacteria all were susceptible to Linezolid, Gentamicin, and Vancomycin. Conclusion: This study showed 90% susceptibility to every class of commonly used antibiotics. Multidrug resistance (MDR) was seen in 9.52% of the bacterial isolates. Antimicrobial resistance is emerging among cancer patients. Studies on cultural sensitivity patterns will help clinicians to prescribe antibiotics judiciously and will further decrease the chances of antimicrobial resistance in these patients.
Neumomediastino traumático secundario al efecto Macklin. Reporte de caso
Authors: Medina-Ortega Marco Antonio , López-Valencia David , Solano-Arboleda Nicolás , Cortés-Bolaños Giovanna
Published: November 2023

Introducción: el neumomediastino (NM) se define como la presencia de aire libre alrededor de las estructuras mediastínicas. Es un hallazgo radiológico poco frecuente y alarmante en el contexto del paciente politraumatizado y su adecuado estudio permite descartar lesiones potencialmente letales. Métodos: se presenta el caso de un paciente masculino de 43 años de edad, ingresado en el contexto de politraumatismo contundente. Al examen físico, se encontraba con enfisema subcutáneo y saturometría limítrofe, con hallazgo tomográfico de NM. Resultados: se practicó esofagogastroduodenoscopia, que reportó normalidad y al examen físico no presentó aumento del enfisema subcutáneo en el seguimiento, catalogando el caso como secundario a efecto Macklin. Posteriormente, el paciente fue egresado en adecuadas condiciones y sin repercusión durante su estancia hospitalaria. Conclusiones: el NM es una entidad poco frecuente, pero alarmante, que obliga al conocimiento de sus causas y estudio de las mismas para descartar lesiones potencialmente letales.
morphological processes of Balish
Authors: Beratha Ni Luh Sutjiati
Published: November 2023

Balinese English which is in this article called Balish has an important role in the world of tourism, namely as one of the most important capital for workers in the field of tourism, and they use Balish.  Tourism workers are classified as lower class such as merchants, masseurs, parking attendants, shop assistants or kiosks, etc. Balish lexicon has gone through morphological processes. These are the proofs that linguistics has been affected, particularly in the field of morphology. Therefore, this article aims to find Balish lexicon along with their morphological processes. The data were taken from tourism workers at Ubud and Tanah Lot. Documentation method and note-taking technique were applied in collecting the data. Yule’s theory of word formation (2020) and morphological processes theory from O’Grady & Archibald (2016) were applied in analyzing the data through descriptive-qualitative method. The results of the research show that there are 12 types of morphological processes found, namely compounding, blending, borrowing, clipping, conversion, initialism, acronym, inflection and derivation, coinage, and multiple processes. The research proves that morphological process is still relevant and has always been the fundamental base in the formation of new lexemes in a constantly advancing world.
Appropriation of Information Systems for Keeping Records of the Implementation Process in Retail Trade
Authors: Kolmykova S. V. , Cherkashnev R. Yu. , Belyaev A. V.
Published: November 2023

Relevance. The modern economy requires a constant increase in the competitiveness of economic entities by reducing uncertainty and minimizing possible risks. As a result, the trading business should be a well-coordinated mechanism aimed at effective management. One of the criteria for effective management is the implementation of competent sales accounting, for the automation of which there are a number of information systems. The purpose of the study is to identify promising aspects of the implementation of information systems aimed at automating the accounting of the sales (sales) process in retail trade. Objectives: a brief overview of information systems as separate specialized programs used to manage sales in retail; development of recommendations for the implementation of software products in non-automated outlets; presentation of the results of automation of business processes through the introduction of information systems. Methodology. In this study, methods of comparative analysis, synthesis, generalization, economic and statistical, as well as graphical methods of information processing were used. Results. The study made it possible to identify promising aspects of the implementation of information systems to automate the accounting of the sales (sales) process in retail trade. The list of relevant information systems of the studied notional area is demonstrated. Recommendations were developed for the implementation of information systems that implement the accounting of retail sales to non-automated outlets. Also, in the course of the work, prospects for the implementation of information ERP systems, in particular, individually configured, taking into account the specifics and features of the company's business processes, were identified. The calculation of the economic efficiency of a pharmacy institution that implements retail trade through the introduction of an information system is presented, as a result of which the importance of automating the accounting of the sales (sales) process is emphasized. Conclusions. Outdated technologies in enterprises significantly complicate the digital transformation of business, despite the variety of ready-made information systems in the subject area under study. The introduction of such systems requires a significant restructuring of organizational changes, business processes, including the adaptation of the accounting system.
Auricular point acupressure in patients with chronic low back pain: A literature study
Authors: Dewi Ervin Septian , Masfuri Masfuri , Arista Liya
Published: November 2023

Background: Chronic low back pain is defined as pain that persists for 12 weeks or more and is a major health problem worldwide and is associated with high medical costs, decreased productivity, and disability. The use of analgesics with nonsteroidal

 

anti-inflammatory drugs or opioids is one of the most common strategies to manage CLBP, but is not free from various adverse side effects. The use of other effective interventions to control pain including non-opioid medications, topical treatments, physical modalities, and complementary and alternative therapies is needed to reduce the side effects resulting from the use of pharmacological therapies. Auricular Point Acupressure is one of the complementary strategies of Traditional Chinese Medicine (TCM) that is widely used clinically to treat pain. APA may be useful for acute or chronic pain, either alone or in combination with other treatments.

Objectives: To analyze the effectiveness of Auricular Point Acupressure for chronic low back pain.

Methods: Literature review through online databases namely: Google Scholar, PubMed, EBSCOhost, and Scopus on articles with free full-text criteria, using Indonesian or English, publication in the last 10 years (2013-2022), and research designs of clinical trials, randomized controlled trials, systematic reviews, meta- analysis. The article search used the keywords (low back pain OR low back pain OR back pain) AND (auriculotherapy OR auricular therapy OR auricular acupressure OR ear acupressure) AND (pain OR disability).

Results: 50 articles were found with 5 articles meeting the inclusion criteria. Of the five articles, the majority explained that the use of Auricular Acupressure is relatively safe and effective for reducing chronic low back pain, some articles showed a decrease in disability rates and improved sleep quality.

Conclusions: Auricular Point Acupressure can be considered a relatively safe and effective complementary therapy fopr reducing chronic low back pain.
Effects of bathing in bed with warm water on vital signs and oxygen saturation in adult patients attached to mechanical ventilators
Authors: Firmansyah Bayu , Hartoyo Mugi , Supadi Supadi , Budiyati Budiyati
Published: November 2023

Background: Illness and hospitalization generally require modifications in personal hygiene practices. During hospitalization and especially in  the Intensive Care Unit (ICU), patients experience situations involving the need for personal hygiene, procedures performed on them due to limitations arising as a result of the ill condition. Bed bathing is an intervention that must be performed in critical patients with the aim of meeting personal hygiene  needs in critical patients, but it is necessary to carry out close monitoring and control to avoid side effects, such as hemodynamic status instability.  

Objectives:: To determine the effect of bathing in bed with warm water on vital signs and oxygen saturation in adult patients attached with mechanical ventilators.

Methods:: This study is a quasi-experimental study involving 18  samples determined by total sampling technique  based on inclusion criteria: Patients attached to mechanical ventilators, aged 18 years or older, stable in hemodynamics and exclusion criteria: Attached drugs for the heart, patients with head injuries, receiving drug therapy to lower body temperature.

Results: The paired t-test results showed an effect between bathing in bed with warm water on systole blood pressure (p = 0.042; p < 0.005), breathing (p = 0.009), and pulse rate (p = 0.025). There was no effect between bathing in bed with warm water on diastole blood pressure (p = 0.063), body temperature (p = 0.862) and oxygen saturation (p = 0.120). 
Conclusions : Bed bathing affects systolic blood pressure, breathing, pulse rate and has no effect on diastolic blood pressure, body temperature, and oxygen saturation. However, during bathing in bed should always pay attention to changes that occur in vital signs and oxygen saturation.
Behavior Change Techniques for the Maintenance of Physical Activity in Cancer
Authors: Edbrooke Lara , Jones Tamara L
Published: November 2023

Ester et al report the findings from a 2-arm cluster randomized controlled trial nested within a hybrid effectiveness-implementation study, which involved a 12-week exercise and behavior change program for rural and remote Canadians (Exercise for Cancer to Enhance Living Well [EXCEL]). The addition of 23 weeks of app-based physical activity monitoring to the EXCEL program did not result in significant between-group differences in physical activity at 6 months. While several behavior change techniques were included in the initial 12-week intervention, additional techniques were embedded within the mobile app. However, there is currently a lack of evidence regarding how many and which behavior change techniques are the most effective for people with cancer and if these differ based on individual characteristics. Potentially, the use of the mobile app was not required in addition to the behavior change support delivered to both groups as part of the EXCEL program. Further research should involve participants who may be in most need of behavioral support, for example, those with lower levels of self-efficacy. Suggestions for future research to tailor behavior change support for people with cancer are discussed.
Older Adults’ Trust and Distrust in COVID-19 Public Health Information: Qualitative Critical Incident Study (Preprint)
Authors: Shiroma Kristina , Zimmerman Tara , Xie Bo , Fleischmann Kenneth R , Rich Kate , Lee Min Kyung , Verma Nitin , Jia Chenyan
Published: November 2023

BACKGROUND

The COVID-19 infodemic has imposed a disproportionate burden on older adults who face increased challenges in accessing and assessing public health information, but little is known about factors influencing older adults’ trust in public health information during COVID-19.

OBJECTIVE

This study aims to identify sources that older adults turn to for trusted COVID-19 public health information and factors that influence their trust. In addition, we explore the relationship between public health information sources and trust factors.

METHODS

Adults aged 65 years or older (N=30; mean age 71.6, SD 5.57; range 65-84 years) were recruited using Prime Panels. Semistructured phone interviews, guided by critical incident technique, were conducted in October and November 2020. Participants were asked about their sources of COVID-19 public health information, the trustworthiness of that information, and factors influencing their trust. Interview data were examined with thematic analysis.

RESULTS

Mass media, known individuals, and the internet were the older adults’ main sources for COVID-19 public health information. Although they used social media for entertainment and personal communication, the older adults actively avoided accessing or sharing COVID-19 information on social media. Factors influencing their trust in COVID-19 public health information included confirmation bias, personal research, resigned acceptance, and personal relevance.

CONCLUSIONS

These findings shed light on older adults’ use of information sources and their criteria for evaluating the trustworthiness of public health information during a pandemic. They have implications for the future development of effective public health communication, policies, and interventions for older adults during health crises.
Use of e-Cigarettes in Cigarette Smoking Cessation: Secondary Analysis of a Randomized Controlled Trial (Preprint)
Authors: Santiago-Torres Margarita , Mull Kristin E , Sullivan Brianna M , Bricker Jonathan B
Published: November 2023

BACKGROUND

Many adults use e-cigarettes to help them quit cigarette smoking. However, the impact of self-selected use of e-cigarettes on cigarette smoking cessation, particularly when concurrently receiving app-based behavioral interventions, remains unexplored.

OBJECTIVE

This study used data from a randomized trial of 2 smartphone apps to compare 12-month cigarette smoking cessation rates between participants who used e-cigarettes on their own (ie, adopters: n=465) versus those who did not (ie, nonadopters: n=1097).

METHODS

The study population included all participants who did not use e-cigarettes at baseline. “Adopters” were those who self-reported the use of e-cigarettes at either 3- or 6-month follow-ups. “Nonadopters” were those who self-reported no use of e-cigarettes at either follow-up time point. The primary cessation outcome was self-reported, complete-case, 30-day point prevalence abstinence from cigarette smoking at 12 months. Secondary outcomes were missing-as-smoking and multiple imputation analyses of the primary outcome, prolonged abstinence, and cessation of all nicotine and tobacco products at 12 months. In logistic regression models, we first examined the potential interaction between e-cigarette use and treatment arm (iCanQuit vs QuitGuide) on the primary cessation outcome. Subsequently, we compared 12-month cigarette smoking cessation rates between adopters and nonadopters separately for each app.

RESULTS

There was suggestive evidence for an interaction between e-cigarette use and treatment arm on cessation (P=.05). In the iCanQuit arm, 12-month cigarette smoking cessation rates were significantly lower among e-cigarette adopters compared with nonadopters (41/193, 21.2% vs 184/527, 34.9%; P=.003; odds ratio 0.55, 95% CI 0.37-0.81). In contrast, in the QuitGuide arm, 12-month cigarette smoking cessation rates did not differ between adopters and nonadopters (46/246, 18.7% vs 104/522, 19.9%; P=.64; odds ratio 0.91, 95% CI 0.62-1.35).

CONCLUSIONS

The use of e-cigarettes while concurrently receiving an app-based smoking cessation intervention was associated with either a lower or an unimproved likelihood of quitting cigarette smoking compared to no use. Future behavioral treatments for cigarette smoking cessation should consider including information on the potential consequences of e-cigarette use.

CLINICALTRIAL

ClinicalTrials.gov NCT02724462; https://clinicaltrials.gov/study/NCT02724462
Feasibility and Effectiveness of a Personalized Home-Based Motor-Cognitive Training Program in Community-Dwelling Older Adults: Protocol for a Pragmatic Pilot Randomized Controlled Trial (Preprint)
Authors: Seinsche Julia , de Bruin Eling D , Saibene Enrico , Rizzo Francesco , Carpinella Ilaria , Ferrarin Maurizio , Ifanger Sarina , Moza Sotiria , Giannouli Eleftheria
Published: November 2023

BACKGROUND

Exergame-based motor-cognitive training in older adults has been associated with improvements in physical, cognitive, and psychological functioning. The novel Cocare system (Dividat GmbH), developed through a user-centered design process, allows motor-cognitive training in a telerehabilitation setting. It includes (1) a stationary stepping platform for supervised exergame training (Dividat Senso; Dividat GmbH), (2) a home-based version (Dividat Senso Flex, which is a rollable pressure-sensitive mat; Dividat GmbH), (3) an assessment system (including motor-cognitive tests), and (4) a rehabilitation cockpit for remote training supervision and management.

OBJECTIVE

The aim of this study is to test the feasibility and effectiveness of this novel training system.

METHODS

A total of 180 older adults from Switzerland, Italy, and Cyprus aged ≥60 years with a prescription for rehabilitation are randomly allocated to an intervention group or a control group. Both groups continue with their usual care, whereas participants in the intervention group additionally perform a 2-week supervised exergame training program at rehabilitation centers, followed by a 10-week home training program under remote supervision. The assessment system is used to indicate the start level of each participant, and, in both intervention periods, standardized progression rules are applied. The measures of feasibility include adherence, attrition, exergame enjoyment, willingness to perform such a training program, and the number and types of help requests. Effectiveness is assessed in terms of cognitive and physical functioning, balance confidence, and quality of life.

RESULTS

Data collection started in February 2023 and is ongoing. Final measurements are expected to be performed in January 2024.

CONCLUSIONS

Owing to the user-centered design approach, the Cocare system is expected to be user-friendly and offers several novel features to cover the whole continuum of care. This pragmatic trial will provide valuable information regarding final necessary adaptations and subsequent implementation efforts.

CLINICALTRIAL

ClinicalTrials.gov NCT05751551; https://www.clinicaltrials.gov/study/NCT05751551

INTERNATIONAL REGISTERED REPORT

DERR1-10.2196/49377
Exploring User Experiences of the Mom2B mHealth Research App During the Perinatal Period: Qualitative Study (Preprint)
Authors: Bilal Ayesha-Mae , Pagoni Konstantina , Iliadis Stavros I , Papadopoulos Fotios C , Skalkidou Alkistis , Öster Caisa
Published: November 2023

BACKGROUND

Perinatal depression affects a significant number of women during pregnancy and after birth, and early identification is imperative for timely interventions and improved prognosis. Mobile apps offer the potential to overcome barriers to health care provision and facilitate clinical research. However, little is known about users’ perceptions and acceptability of these apps, particularly digital phenotyping and ecological momentary assessment apps, a relatively novel category of apps and approach to data collection. Understanding user’s concerns and the challenges they experience using the app will facilitate adoption and continued engagement.

OBJECTIVE

This qualitative study explores the experiences and attitudes of users of the Mom2B mobile health (mHealth) research app (Uppsala University) during the perinatal period. In particular, we aimed to determine the acceptability of the app and any concerns about providing data through a mobile app.

METHODS

Semistructured focus group interviews were conducted digitally in Swedish with 13 groups and a total of 41 participants. Participants had been active users of the Mom2B app for at least 6 weeks and included pregnant and postpartum women, both with and without depression symptomatology apparent in their last screening test. Interviews were recorded, transcribed verbatim, translated to English, and evaluated using inductive thematic analysis.

RESULTS

Four themes were elicited: acceptability of sharing data, motivators and incentives, barriers to task completion, and user experience. Participants also gave suggestions for the improvement of features and user experience.

CONCLUSIONS

The study findings suggest that app-based digital phenotyping is a feasible and acceptable method of conducting research and health care delivery among perinatal women. The Mom2B app was perceived as an efficient and practical tool that facilitates engagement in research as well as allows users to monitor their well-being and receive general and personalized information related to the perinatal period. However, this study also highlights the importance of trustworthiness, accessibility, and prompt technical issue resolution in the development of future research apps in cooperation with end users. The study contributes to the growing body of literature on the usability and acceptability of mobile apps for research and ecological momentary assessment and underscores the need for continued research in this area.
Interoperability and electronic health records (EHR) standards in medicine (Preprint)
Authors: Nair Rajesh
Published: November 2023

BACKGROUND

Interoperability and electronic health records (EHR) standards in medicine

OBJECTIVE

What is the latest evidence related to EHR data interoperability, and standards in medicine?

METHODS

N/A

RESULTS

The need for interoperability is evident in every part of a typical health care organization, as many clinicians in a hospital setting need to communicate with their counterparts in the community and as such the EHRs should be able to share data automatically and seamlessly across institutions and display it in useful ways.

CONCLUSIONS

Currently, a usable and reliable patient data at the point of care regardless of socioeconomic background is critical to the management of patients in medicine, especially the chronically ill.
Improving communication and decision-making process during consent among elderly patients for research trials using EHRs: A medico-legal perspective (Preprint)
Authors: Nair Rajesh
Published: November 2023

BACKGROUND

In British Columbia there has been an increase in the elderly population with current estimates at 700,5001. Clinical trials are one type of research involving experiments or observations designed to answer specific questions about new treatments and known interventions that warrant further study or comparison. The informed consent (IC) process can be very confusing for the elderly pertaining to electronic health record (EHR) data storage.

OBJECTIVE

We postulate that to improve IC communication and decision-making HCPs must be considered from the medico-legal perspective.

METHODS

N/A

RESULTS

IC process is complex and cognitive assessments should be considered for determining capacity.

CONCLUSIONS

IC can be challenging for the elderly patient.
Exploring Women’s Lived Experiences of Early Marriage in Rural Indonesia
Authors: Yunizar Cahya H. , Xiong Zha B. , Solheim Catherine
Published: November 2023

Early marriage is still a global concern, and Indonesia ranks second behind Cambodia in the number of early marriages within the ASEAN region. Despite the spread of technology and the influence of Western media, some Indonesian families, especially those who live in rural areas, continue to practice early marriage. Therefore, the purpose of this study was to understand the reasons behind early marriage based on the perspective of Indonesian women who were married before the age of 18. Based on a phenomenological approach, thirty women, ages 18-45, from the Madurese community in Situbondo, East Java participated in the study. Results showed that young Madurese women decided to get married for love and companionship, as well as for economic benefits and protecting the family’s honor. Participants also believed that cultural norms and values related to marriage, sexual purity, and gender expectations play a role in early marriage. Suggestions for future studies and community interventions are discussed.
Nanofibers: An Effective Biomedical Tool for Burn Management
Authors: Punjaram Miss. Mahale Gayatri
Published: November 2023

Abstract: The largest organ in the body and the organ that interacts most directly with the environment is the skin. As a result, the skin is susceptible to numerous injuries, including burns. Cell types, cytokines, mediators, the neurovascular system, and matrix remodelling work in concert to heal skin wounds. Through re-epidermalization, interactions between epidermal and stromal cells, angiogenesis, and habitation of hypertrophic scars and keloids, tissue regeneration technology significantly improves skin restoration. With the use of several skin substitutes, skin healing success rates for burn injuries have dramatically increased. For the reconstruction of skin tissue, we examine the use of cells, growth factors, scaffolds, or scaffolds seeded with cells in this review. We also compare the high efficacy and affordability of each therapy. We outline the key components, successes, and difficulties of cell-based therapy for minimising scar formation and enhancing the management of burn injuries.