bluuebunny/crossref_metadata_2025 huggingface dataset:
Cellular manufacturing system: a descriptive bibliometric analysis, framework, implementation steps and future research direction
Authors: Sharma Vikrant , Nimawat Dheeraj
Published: May 2023

Purpose

The purpose of this article is to conduct a bibliometric analysis of the cellular manufacturing system (CMS) literature published from 1982–2021 to identify key issues and trends for the future.

Design/methodology/approach

A six-stage methodology is used to conduct a literature review, which includes: (1) article collection; (2) inclusion/exclusion criteria; (3) reviewing the articles; (4) analyzing the articles; (5) framework development; and (6) future research directions. A total of 936 CMS-specific articles are reviewed. This paper made use of three software tools: the R package, VOSviewer and SciMAT.

Findings

According to the findings, the majority of CM researchers focused on cell formation and design. The USA, Iran and India are the top three leading publishers. Additionally, the gap and future direction of CM are discussed.

Originality/value

To the best of the authors' knowledge, the current study is the first attempt to investigate CMS evaluation through bibliometric and thematic analysis and provides a decisional framework as well as steps for CMS adoption. For individuals who are interested in understanding more about CMS and its evolution, this paper offers a starting point.
COVID-19 communication management in Europe: a comparative analysis of the effect of information-seeking in the public’s sense-making in Italy, Spain and the United Kingdom
Authors: Moreno Angeles , Fuentes Lara Cristina , Tench Ralph , Romenti Stefania
Published: May 2023

Purpose

Governments around the world have shown poor capabilities in responding effectively to the COVID-19 health emergency outbreaks. After the declaration of COVID-19 as an international pandemic by the World Health Organization on January 31, 2020, three countries experienced the greatest initial impact in Europe. Sequentially Italy, Spain and the United Kingdom (UK) were hit by the highest numbers of contagion and death in the first few months in Europe. The aim of this paper is to assess how information channels and sources influenced the public’s evaluation of the three government’s communication response strategies.

Design/methodology/approach

An online survey was conducted between March 14 and April 14, 2020, during the first wave of lockdowns and declarations of States of Emergency in the three countries.

Findings

Findings show particularities for the different countries, but also similarities in response and reactions of the public in the three scenarios. The response strategy of the UK Government was the most untrusted and criticized by citizens. In contrast, the Italian and Spanish Governments, which both chose to respond with the severest restrictions, attracted more support from citizens, especially in Italy, which was the first to close borders and impose lockdowns for the population.

Research limitations/implications

Despite the national differences in the preference of information channels and sources, overall, an empirical relationship between government communication assessment and media use were found in all the scenarios.

Practical implications

This empirical study has theoretical and practical implications. Theoretically, findings will add evidence of implications of the Channel Complementary Theory to the field of risk, crisis and emergency communication. The results also provide insights for communication practitioners in the public sector on how forms of information and trust in sources influence the public’s assessment of authorities’ communication.

Originality/value

Implications for theory and empirical research about communication during a health pandemic are identified and discussed.

Highlights

Citizens engage at a high level and synchronize their use of multiple media and platforms in all the three national scenarios.

Stronger criticism is provided by online media, especially social media and online press in the different national contexts.

Results corroborate that factors related to media choice need to be operationalized for risk and crisis communication research.

When public health depends on people understanding the actions they need to take, the possibility of disobedience is highly dependent on trust.

Compared with Spain and the United Kingdom (UK), trust in government institutions in Italy was stronger and could be explained by the higher use of owned media for information-seeking.
How climate-included variations in crop yields affect migration in India
Authors: Mohapatra Souryabrata , Das Amarendra , Sahoo Dukhabandhu , Sharp Basil , Sahoo Auro Kumar
Published: May 2023

Purpose

The study unravels the effects of climate-induced variations in staple crop yields on various migratory inflows in India while adjusting for seasonal weather and sociodemographic factors.

Design/methodology/approach

The instrumental variable approach is used to assess the potential effects of climate and nonclimate parameters on various migration types, exploiting panel data at the district level from the 2001 and 2011 Census years, with agriculture acting as the mediator.

Findings

As weather-driven variations in rice and wheat yield increase by 10%, the share of migration within and between districts to population decreases by 0.017 and 0.002, respectively. However, rice and wheat yields increase by 494.60 and 524.40%, respectively, with a marginal increase in the share of migration within states to population. Also, the elasticities of disadvantaged groups, literate locals and agricultural workers vary for different relocations.

Originality/value

The current study affirms climate migration through the agricultural channel at a finer spatial scale, asserting the sensitivity aspect of disparate movements to periodic weather and heterogeneous clusters. This is critical for effectively implementing targeted public policies in the face of increasing climate risks.

Peer review

The peer review history for this article is available at https://publons.com/publon/10.1108/IJSE-10-2022-0710
Understanding tour operators’ perception and behaviour towards shopping streets: a qualitative perspective
Authors: Baharum Baizuri , Zahari Mohd Salehuddin Mohd , Hanafiah Mohd Hafiz , Bashir Muhammad A’rif Aizat
Published: May 2023

Purpose

The importance of shopping streets has long been considered a critical aspect of urban tourism. However, limited exploration focuses on the supply side, especially from the tour operator’s (TO) perspective. This paper aims to investigate TOs’ perceptions and attitudes towards packaging Tuanku Abdul Rahman Street (TARS) as an urban shopping spot in Kuala Lumpur.

Design/methodology/approach

Study data is gathered through qualitative in-depth interviews among 25 TO managers in Kuala Lumpur, Malaysia. The coding process was done manually, followed by qualitative data analysis using ATLAS.ti version 8 software.

Findings

The results show that the TOs regarded TARS as a must-visit shopping spot for international tourists. They argue that TARS’s competitiveness as a shopping street depends on the supporting infrastructure and safe environment, which are currently neglected by the relevant authorities and jeopardise the sustainability of TARS as a must-visit shopping street in the future.

Practical implications

This study’s findings generate value-added information on the potential of shopping tourism and TARS as must-visit shopping streets in Malaysia. On the other hand, the TOs’ concern about the lack of supporting infrastructure and unsafe environment generates varying consequences and implications for the individual TOs, tourism policymakers and government-related authorities.

Originality/value

This study offers new insight for urban tourism policymakers, managers and entrepreneurs to capture the attributes of a vibrant shopping street. There is exclusive potential for local tourism operators to take greater responsibility in shopping tourism planning processes and management operations through trustworthy planning partnerships among respective tourism stakeholders related to the shopping street domain.
Cause – effect relationship of trust of buyer – suppliers' integration on procurement performance in large manufacturing firms in Tanzania
Authors: Kimario Honest F. , Kira Alex R.
Published: May 2023

Purpose

The purpose of this study was to establish the cause-effect relationship between determinants of trust in the buyer–supplier integration and the procurement performance of large manufacturing firms in Tanzania.

Design/methodology/approach

The study surveyed 52 firms from Temeke Municipality, Tanzania using questionnaire subjected to one procurement manager and one stores manager tallying a sample size of 104 respondents. Explanatory design was employed due to the presence of cause–effect relationship and the null hypotheses were tested using binary logistic regression technique at p values < 0.05 and ExpB > 1.

Findings

Mutual goals, geographical vicinity among partners, and supplier reliability are significant for the procurement performance of the manufacturing firms in Tanzania, whereas interpersonal and inter-organizational trusts and perceived buyers’ confidence are of no significant impact.

Research limitations/implications

Buyer–supplier integration is a recently embraced and paramount practice for the manufacturing firms in Tanzania. Therefore, longitudinal study would further add value. The presence of the causality from the tested hypothesis appeals for the necessity of progress tracking.

Practical implications

Causality has been established, and a framework has been developed for the performance of large manufacturing firms using trust of buyer–supplier integration.

Social implications

There shall be creation of more employment opportunities and timely availability of materials from large manufacturing firms in Tanzania.

Originality/value

Anchored on transaction cost economics and resource dependency theories, the study disclosed the root cause of procurement performance in the context of manufacturing firms in Tanzania whilst considering trust as a resource advantage of buyer–supplier integration.
What are the consequences of corporate greenwashing? A look into the consequences of greenwashing in consumer and financial markets
Authors: Teichmann Fabian Maximilian Johannes , Wittmann Chiara , Sergi Bruno Sergio S.
Published: May 2023

Purpose

The purpose of this paper is to explore the nuances of the consequences of greenwashing in the consumer and financial markets. Greenwashing is discussed frequently but in very abstract terms. Hence, a closer examination of the palpable consequences elucidates the ripple effects of this widespread phenomenon.

Design/methodology/approach

Focal points are the concept of green marketing, the stigmatization of corporations in the media and the regulatory consequences of greenwashing behaviour across consumer and financial markets. The two markets are paralleled in order to trace the novelties as well as the points of commonality in greenwashing.

Findings

The current consequences are an insufficient deterrence in both markets. The regulatory trend in both markets is leaning towards more stringent and punitive measures, which will likely affect the efficacy of the deterrence factor.

Originality/value

The influence on consumer perception is identified both as a motivating factor for greenwashing and as one of the most immediate elements which is negatively influenced by its exposition. In addition to the fact that greenwashing practices are common across the two markets, this paper identifies that a systemic deterioration of investor trusts significantly compromises the potential of sustainable finance and impacts investment in the financial market, mirrored in the negative consequences on consumer reactions to greenwashed products.
Using approach-inhibition theory of power to explain how participative decision-making enhances innovative work behavior of high power distance-oriented employees
Authors: Farzana Sumaia , Charoensukmongkol Peerayuth
Published: May 2023

Purpose

This research study investigated the relationship between participative decision-making and innovative work behavior by considering the moderating role of power distance orientation of individuals. Grounded in the approach-inhibition theory of power, the authors proposed that participative decision-making could mitigate perceived power gap and motivate individuals with high power distance orientation to engage more in innovative work behavior.

Design/methodology/approach

Survey data were collected from 243 faculty members from 2 universities located at Dhaka, Bangladesh. The partial least squares structural equation modeling (PLS-SEM) was used for data analysis.

Findings

The results from the model estimation showed that the positive relationship between participative decision-making and innovative work behavior was stronger among faculty members with high power distance orientation than those with low power distance orientation. The simple slope analysis also clarified the fact that faculty members with high power distance orientation could increase their innovative work behavior to be at the same level as that of faculty members with low power distance orientation when the members were involved highly in participative decision-making.

Practical implications

Participative decision-making is a management practice that should be implemented in order to motivate faculty members to actively engage in innovative work behavior. Particularly for faculty members who are sensitive towards the power status of other members in the workplace, this management practice is highly recommended to lessen the perceived social barrier that discourages these faculty members from engaging in innovative work behavior.

Originality/value

The authors' research advanced knowledge from prior studies by offering new theoretical insight into the role of empowerment practice that could motivate individuals with high power distance orientation to engage more in innovative practices.
Knowledge mining and graph visualization of ancient Chinese scientific and technological documents bibliographic summaries based on digital humanities
Authors: Zheng Xiang , Li Mingjie , Wan Ze , Zhang Yan
Published: May 2023

Purpose

This study aims to extract knowledge of ancient Chinese scientific and technological documents bibliographic summaries (STDBS) and provide the knowledge graph (KG) comprehensively and systematically. By presenting the relationship among content, discipline, and author, this study focuses on providing services for knowledge discovery of ancient Chinese scientific and technological documents.

Design/methodology/approach

This study compiles ancient Chinese STDBS and designs a knowledge mining and graph visualization framework. The authors define the summaries' entities, attributes, and relationships for knowledge representation, use deep learning techniques such as BERT-BiLSTM-CRF models and rules for knowledge extraction, unify the representation of entities for knowledge fusion, and use Neo4j and other visualization techniques for KG construction and application. This study presents the generation, distribution, and evolution of ancient Chinese agricultural scientific and technological knowledge in visualization graphs.

Findings

The knowledge mining and graph visualization framework is feasible and effective. The BERT-BiLSTM-CRF model has domain adaptability and accuracy. The knowledge generation of ancient Chinese agricultural scientific and technological documents has distinctive time features. The knowledge distribution is uneven and concentrated, mainly concentrated on C1-Planting and cultivation, C2-Silkworm, and C3-Mulberry and water conservancy. The knowledge evolution is apparent, and differentiation and integration coexist.

Originality/value

This study is the first to visually present the knowledge connotation and association of ancient Chinese STDBS. It solves the problems of the lack of in-depth knowledge mining and connotation visualization of ancient Chinese STDBS.
Strategic responses to environmental performance monitoring barriers: a case study of Malaysian Government green procurement
Authors: Vejaratnam Navarani , Chenayah Santha , Mohamad Zeeda Fatimah , Appolloni Andrea
Published: May 2023

Purpose

This study aims to investigate the potential influence of organisational responses to conflicting institutional demands towards barriers to environmental performance (EP) monitoring of government green procurement (GGP) in Malaysia.

Design/methodology/approach

The paper used a qualitative methodology based on a single case study involving policymakers, procurement officials and a monitoring authority. The study data were analysed drawing on the perspectives of organisational responses to conflicting institutional demands.

Findings

The three key challenges that hindered EP monitoring of GGP in Malaysia were policy irregularities, knowledge asymmetry and communication gaps. These challenges are likely the consequences of the acquiescence, avoidance, compromise and defiance strategies commonly used in dealing with the institutional complexity faced in Malaysia’s public policy arena.

Practical implications

The government, at various institutional levels, may benefit from the theoretical and empirical findings of the case study. Knowledge of barriers can facilitate the policymakers in designing the monitoring process meticulously. Meanwhile, awareness of the influence of organisational responses to institutional complexity on GGP barriers can help redefine field actors’ interests and values in improving policy monitoring. In addition, reporting of the monitored EP bridges the institutional gaps between the macro-state level and the micro-organisational level of GGP, besides increasing the government’s transparency and accountability regarding green procurement.

Social implications

Fewer challenges in the EP monitoring system contribute to an improved GGP policy. In turn, an improved policy may enhance public health and reduce environmental degradation.

Originality/value

The study contributes to the GGP monitoring and institutional theory by showing that barriers to EP monitoring culminate from the organisational response to the institutional demands faced in the policy environment. The authors argue that this is one of the few studies that have examined the barriers to EP monitoring of public policy explicated in the context of organisational responses to institutional demands.
Electoral Democracy and Working‐Age Mortality
Authors: MONTEZ JENNIFER KARAS , CHENG KENT JASON , GRUMBACH JACOB M.
Published: May 2023

Policy Points

The erosion of electoral democracy in the United States in recent decades may have contributed to the high and rising working‐age mortality rates, which predate the COVID‐19 pandemic.

Eroding electoral democracy in a US state was associated with higher working‐age mortality from homicide, suicide, and especially from drug poisoning and infectious disease.

State and federal efforts to strengthen electoral democracy, such as banning partisan gerrymandering, improving voter enfranchisement, and reforming campaign finance laws, could potentially avert thousands of deaths each year among working‐age adults.

Context

Working‐age mortality rates are high and rising in the United States, an alarming fact that predates the COVID‐19 pandemic. Although several reasons for the high and rising rates have been hypothesized, the potential role of democratic erosion has been overlooked. This study examined the association between electoral democracy and working‐age mortality and assessed how economic, behavioral, and social factors may have contributed to it.

Methods

We used the State Democracy Index (SDI), an annual summary of each state's electoral democracy from 2000 to 2018. We merged the SDI with annual age‐adjusted mortality rates for adults 25–64 years in each state. Models estimated the association between the SDI and working‐age mortality (from all causes and six specific causes) within states, adjusting for political party control, safety net generosity, union coverage, immigrant population, and stable characteristics of states. We assessed whether economic (income, unemployment), behavioral (alcohol consumption, sleep), and social (marriage, violent crime, incarceration) factors accounted for the association.

Findings

Increasing electoral democracy in a state from a moderate level (defined as the third quintile of the SDI distribution) to a high level (defined as the fifth quintile) was associated with an estimated 3.2% and 2.7% lower mortality rate among working‐age men and women, respectively, over the next year. Increasing electoral democracy in all states from the third to the fifth quintile of the SDI distribution may have resulted in 20,408 fewer working‐age deaths in 2019. The democracy–mortality association mainly reflected social factors and, to a lesser extent, health behaviors. Increasing electoral democracy in a state was mostly strongly associated with lower mortality from drug poisoning and infectious diseases, followed by reductions in homicide and suicide.

Conclusions

Erosion of electoral democracy is a threat to population health. This study adds to growing evidence that electoral democracy and population health are inextricably linked.
Chromosome‐level genome assembly of the Asian citrus psyllid, Diaphorina citri
Authors: Lei Shuang , Yu Shi‐Jiang , Pan Qi , Ding Li‐Li , Li Si‐Chen , Cheng Lu‐Yan , Wang Shu‐Qi , Lou Bing‐Hai , He Jun , Lei Cui‐Yun , Cong Lin , Liu Hao‐Qiang , Wang Xue‐Feng , Ran Chun
Published: May 2023

Diaphorina citri is a global citrus pest. As a vector insect, it can transmit the causative agents of citrus huanglongbing, causing irreversible losses to the citrus industry. The acquisition of genomic information can provide a molecular genetic basis for effective control of D. citri. Here, the DNBSEQ™, Oxford Nanopore Technologies, and Hi‐C technologies are applied to generate a high‐quality chromosome‐level genome of D. citri. The genome size of D. citri was 523.78 Mb with a scaffold N50 of 47.05 Mb distributed on 13 chromosomes. A total of 250.64 Mb (47.85%) repeat sequences and 24 048 protein‐coding genes were predicted. Genome resequencing of female and male individuals indicated that the sex chromosome system of D. citri is XO. Phylogenetic analysis demonstrated that D. citri and Pachypsylla venusta, which separated from their most recent common ancestor about 336.62 million years ago, were the most closely related. Additionally, we identified genes potentially involved in detoxification metabolism, pathogen transmission, and honeydew secretion for further investigation. The high‐quality genome provides an important reference for developing effective management strategies of D. citri.
Factors affecting presenteeism in workers with nocturnal hemodialysis: A two‐center cross‐sectional study
Authors: Yabe Hiroki , Tabata Aki , Sugimoto Norihisa , Saeki Tomohiro , Tsukada Takeshi , Mohara Jin
Published: May 2023

Introduction

Presenteeism and work dysfunction in dialysis patients should be assessed to improve disease management and work productivity. Therefore, this study aimed to investigate the prevalence and factors surrounding presenteeism and work dysfunction in workers with nocturnal hemodialysis.

Methods

This multicenter cross‐sectional study included 42 workers with nocturnal hemodialysis. Presenteeism was measured in patients using the Work Functioning Impairment Scale (WFun), employment status, exercise habit, and exercise self‐efficacy (SE).

Results

The WFun score was 12.5 ± 6.3 points, and patients with mild presenteeism were 12 (28.6%), moderate was 2 (4.8%), and severe was 1 (2.4%). Multiple regression analysis, which was adjusted for few confounding factors, showed that WFun had a significant relationship with lower exercise SE (r = −0.32) and normalized protein catabolism rate (r = 0.31).

Conclusions

Working patients with nocturnal hemodialysis had presenteeism and a significant correlation with exercise SE and nPCR. This study provides a framework to prevent work dysfunction in nocturnal hemodialysis patients.
A novel molecular mechanism mediated by circCCDC134 regulates non‐small cell lung cancer progression
Authors: Tong Zhufeng , Wang Zhen , Jiang Jinghan , Tong Chengcheng , Wu Lan
Published: May 2023

Background

Circular RNA (circRNA) plays a crucial role in non‐small cell lung cancer (NSCLC) progression. However, the role of circCCDC134 in NSCLC is still largely unknown.

Methods

Quantitative real‐time PCR was utilized for measuring circCCDC134, microRNA (miR)‐625‐5p and nuclear factor of activated T cell 5 (NFAT5) expression. Cell functions were evaluated by colony formation, EdU, transwell, and wound healing assays and flow cytometry. Glucose consumption, lactate production, and ATP level were determined to analyze cell glycolysis. Western blot analysis was used to detect protein expression. Animal experiments were performed to assess the effect of circCCDC134 on NSCLC tumor growth. RNA interaction was evaluated by dual‐luciferase reporter assay and RIP assay. Exosomes were isolated from the serum of NSCLC patients and healthy normal controls.

Results

Highly expressed circCCDC134 was found in NSCLC tissues and cells, as well as in the serum exosomes of NSCLC patients. Downregulated circCCDC134 restrained NSCLC cell growth, metastasis and glycolysis. CircCCDC134 sponged miR‐625‐5p to regulate NFAT5. MiR‐625‐5p inhibitor abolished the regulation of circCCDC134 knockdown on NSCLC progression, and NFAT5 overexpression eliminated the effects of miR‐625‐5p on NSCLC cell behaviors. CircCCDC134 knockdown also inhibited NSCLC tumor growth.

Conclusion

Our study revealed that circCCDC134 was involved in regulating NSCLC progression through the miR‐625‐5p/NFAT5 pathway, confirming that circCCDC134 might function as the diagnostic and therapeutic target for NSCLC.
Population pharmacokinetic and exposure‐response modelling to inform upadacitinib dose selection in adolescent and adult patients with atopic dermatitis
Authors: Ismail Mohamed , Doelger Eva , Eckert Doerthe , Irvine Alan D. , Chu Alvina D. , Teixeira Henrique D. , Liu Wei , Nader Ahmed
Published: May 2023

Aims

First, population pharmacokinetic analyses were used to characterize upadacitinib pharmacokinetics in adolescent and adult participants with atopic dermatitis (AD) and to identify patient covariates that may impact upadacitinib pharmacokinetics. Second, the exposure‐response relationship for upadacitinib with efficacy and safety endpoints, and the effect of age and concomitant use of topical corticosteroids (TCS) on the exposure‐response relationship and dose selection for patients with AD were evaluated.

Methods

A two‐compartment model with combined first‐ and zero‐order absorption adequately characterized the upadacitinib concentration‐time profiles in 911 healthy volunteer adolescent and adult participants with AD who received upadacitinib 15 or 30 mg orally once daily (QD) as monotherapy or in combination with TCS for 16 weeks. Logistic regression models were developed to characterize the exposure‐efficacy and safety relationships, and simulations were performed based on final exposure‐response models to predict efficacy responses in participants with AD who received placebo or upadacitinib as monotherapy or in combination with TCS.

Results

Upadacitinib exposures were comparable between adolescents and adults. Mild or moderate renal impairment was predicted to increase the upadacitinib area under the plasma concentration‐time curve from time zero to 24 h after dosing (AUC24) approximately 12% and 25%, respectively, compared to participants with normal renal function. Female participants were predicted to have 20% higher AUC24 compared to male participants. Participants with AD were predicted to have 18% higher AUC24 compared to healthy participants. Simulated clinical efficacy responses showed added clinical efficacy benefit for all endpoints evaluated (8‐14%) with the upadacitinib 30 mg once‐daily regimen compared to 15 mg once‐daily in both age groups. In participants receiving upadacitinib in combination with TCS, significant exposure‐dependent increases in upadacitinib efficacy endpoints were observed. No significant effects of age or weight were identified in any of the exposure‐response models.

Conclusion

The results of these analyses support the dose justification for upadacitinib in adult and adolescent patients with moderate to severe AD.
‘All of a sudden for no reason they've been displaced’: Constructing the ‘contingent refugee’ in early media reports on the Ukrainian refugees
Authors: Sambaraju Rahul , Shrikant Natasha
Published: May 2023

This paper analyzes descriptions of Ukrainian refugees in the aftermath of the Russian invasion of Ukraine. Findings of previous research on news media descriptions of refugees point to problematic descriptions of refugees that downgrade their deservingness of refuge and treat refugee status as an inherent feature of fleeing individuals instead of as contingent on external circumstances. However, there is a widespread perception that Ukrainian refugees are being reported on in a more positive light. We therefore examine how news media describe these refugees. Our corpus includes English media news coverage from February 25, 2022, to March 25, 2022, the initial period of the invasion. A discursive psychological analysis of news interactions where hosts elicit information from correspondents about current ongoings with Ukrainian refugees shows that Ukrainian refugees are constructed as vulnerable, and their actions are treated as reasonable given the situation. These descriptions construct Ukrainian refugees as those who are only contingently refugees and legitimate help‐giving by other parties. Our findings, therefore, highlight distinct, previously unanalyzed ways that refugees are constructed: contingent refugees. We discuss implications of our findings for understanding refugee inclusion and exclusion.
A cognitive balance approach to understanding intergroup attitudes in post‐Brexit Northern Ireland
Authors: Loughnane Jack , Roth Jenny , van Tilburg Wijnand
Published: May 2023

Cognitive balance theory posits that a drive for cognitively consistent thoughts modulates interpersonal relations. We extended cognitive balance theory to intergroup relations and tested it in a real‐life setting where intergroup relations are under strain: Northern Ireland in the wake of the UK's withdrawal from the EU. We predicted that when the groups of Irish people and British people in Northern Ireland are perceived as more compatible, intergroup bias would be lower than when groups are perceived as less compatible. We collected data of residents of Northern Ireland before the UK's official withdrawal from the EU (N = 604) and after (N = 350). As hypothesized, attitudes towards British people positively related to attitudes towards Irish people when participants perceived the groups as more compatible. We found the opposite relationship at low levels of perceived compatibility. Exploratory cross‐lagged panel analyses did not show that these effects occurred longitudinally, suggesting that cognitive balance does not drive judgements over time possibly because people are less likely to notice inconsistent responses across different time points. The present research demonstrates that intergroup attitudes assessed at a certain point in time follow cognitive balance principles.
Unravelling rift propagation from Cenozoic subsidence patterns: Examples from the Dangerous Grounds, South China Sea
Authors: Fang Penggao , Ding Weiwei , Wei Xiaodong , Zhao Yanghui
Published: May 2023

How seafloor spreading in marginal basins controls subsidence patterns in continental margins under rift propagation settings remains poorly understood. Herein, based on detailed geological interpretation and backstripping of 37 high‐resolution multichannel seismic reflection sections, we calculate the Cenozoic tectonic subsidence across the Dangerous Grounds (DG), South China Sea, in order to study interactions between seafloor spreading and the propagation of rift basins. Our results show that rapid subsidence occurred in the eastern Dangerous Grounds (EDG) from the Palaeocene to early Oligocene, then migrated westwards to the middle Dangerous Grounds (MDG) during the early Oligocene to early Miocene, and finally reached the western Dangerous Grounds (WDG) during the early to middle Miocene. We interpret this western migration of intensive subsidence as the response of the inherited pre‐Cenozoic heterogeneous lithospheric structure of South China. Thermal re‐equilibration of the lithosphere then dominated the rapid post‐spreading subsidence throughout the whole DG from the middle Miocene. An anomalous subsidence deficit occurred in the EDG during the early Oligocene to early Miocene, and in the MDG during the early to middle Miocene; this phenomenon might be related to small‐scale mantle convection associated with the propagation of seafloor spreading from east to southwest.
Assessment of joint bleeding and target joints in patients with severe or moderately severe hemophilia B (factor IX ≤2%) receiving prophylaxis with rIX‐FP in the PROLONG‐9FP clinical trial program
Authors: Laws Hans‐Juergen , Fukutake Katsuyuki , Lopez‐Fernandez Maria Fernanda , Li Yanyan , Seifert Wilfried , Tagliaferri Annarita
Published: May 2023

Objective

To assess the impact of prophylaxis with rIX‐FP, a fusion protein linking recombinant factor IX (FIX) with human albumin, on joint outcomes.

Methods

Joint outcomes were assessed in pediatric (<12 years) and adult/adolescent (≥12 years) patients receiving rIX‐FP prophylaxis every 7, 10, or 14 days; patients (>18 years) well‐controlled on a 14‐day regimen could switch to a 21‐day regimen. Target joints were defined as ≥3 spontaneous bleeds into a single joint within a 6‐month period.

Results

For adult/adolescent (n = 63) and pediatric (n = 27) patients, median (Q1, Q3) annualized joint bleeding rate was 0.39 (0.00, 2.31), 0.80 (0.00, 2.85), 0.20 (0.00, 2.58), and 0.00 (0.00, 1.78) when treated with 7‐, 10‐, 14‐, or 21‐day prophylaxis. 50.0%, 38.9%, 45.5%, and 63.6% of adult/adolescent patients had no joint bleeds when treated with 7‐, 10‐, 14‐, or 21‐day prophylaxis, respectively, and 40.7%, 37.5%, and 37.5% of pediatric patients had no joint bleeds when treated with 7‐, 10‐, or 14‐day prophylaxis. Ten adult and two pediatric patients developed target joints; all resolved by the end of the study.

Conclusion

Prophylaxis with rIX‐FP produced low joint bleeding rates and provided excellent hemostatic efficacy in the treatment of joint bleeds. All target joints reported resolved with rIX‐FP prophylaxis.
Long‐term follow‐up of 64 children with classical infantile‐onset Pompe disease since 2004: A French real‐life observational study
Authors: Tardieu Marine , Cudejko Céline , Cano Aline , Hoebeke Célia , Bernoux Delphine , Goetz Violette , Pichard Samia , Brassier Anaïs , Schiff Manuel , Feillet François , Rollier Paul , Mention Karine , Dobbelaere Dries , Fouilhoux Alain , Espil‐Taris Caroline , Eyer Didier , Huet Frédéric , Walther‐Louvier Ulrike , Barth Magalie , Chevret Laurent , Kuster Alice , Lefranc Jérémie , Neveu Julien , Pitelet Gaele , Ropars Juliette , Rivier François , Roubertie Agathe , Touati Guy , Vanhulle Catherine , Tardieu Emilie , Caillaud Catherine , Froissart Roseline , Champeaux Murielle , Labarthe François , Chabrol Brigitte
Published: May 2023

Background

Classical infantile‐onset Pompe disease (IOPD) is the most severe form of Pompe disease. Enzyme replacement therapy (ERT) has significantly increased survival but only a few studies have reported long‐term outcomes.

Methods

We retrospectively analyzed the outcomes of classical IOPD patients diagnosed in France between 2004 and 2020.

Results

Sixty‐four patients were identified. At diagnosis (median age 4 months) all patients had cardiomyopathy and most had severe hypotonia (57 of 62 patients, 92%). ERT was initiated in 50 (78%) patients and stopped later due to being ineffective in 10 (21%). Thirty‐seven (58%) patients died during follow‐up, including all untreated and discontinued ERT patients, and 13 additional patients. Mortality was higher during the first 3 years of life and after the age of 12 years. Persistence of cardiomyopathy during follow‐up and/or the presence of heart failure were highly associated with an increased risk of death. In contrast, cross‐reactive immunologic material (CRIM)‐negative status (n = 16, 26%) was unrelated to increased mortality, presumably because immunomodulation protocols prevent the emergence of high antibody titers to ERT. Besides survival, decreased ERT efficacy appeared after the age of 6 years, with a progressive decline in motor and pulmonary functions for most survivors.

Conclusions

This study reports the long‐term follow‐up of one of the largest cohorts of classical IOPD patients and demonstrates high long‐term mortality and morbidity rates with a secondary decline in muscular and respiratory functions. This decreased efficacy seems to be multifactorial, highlighting the importance of developing new therapeutic approaches targeting various aspects of pathogenesis.
Globus pallidus internus versus subthalamic nucleus deep brain stimulation for isolated dystonia: A 3‐year follow‐up
Authors: Lin Suzhen , Shu Yimei , Zhang Chencheng , Wang Lingbing , Huang Peng , Pan Yixin , Ding Jianqing , Sun Bomin , Li Dianyou , Wu Yiwen
Published: May 2023

Background and purpose

Bilateral deep brain stimulation (DBS) surgery targeting the globus pallidus internus (GPi) or the subthalamic nucleus (STN) is widely used in medication‐refractory dystonia. However, evidence regarding target selection considering various symptoms remains limited. This study aimed to compare the effectiveness of these two targets in patients with isolated dystonia.

Methods

This retrospective study evaluated 71 consecutive patients (GPi‐DBS group, n = 32; STN‐DBS group, n = 39) with isolated dystonia. Burke–Fahn–Marsden Dystonia Rating Scale scores and quality of life were evaluated preoperatively and at 1, 6, 12, and 36 months postoperatively. Cognition and mental status were assessed preoperatively and at 36 months postoperatively.

Results

Targeting the STN (STN‐DBS) yielded effects within 1 month (65% vs. 44%; p = 0.0076) and was superior at 1 year (70% vs. 51%; p = 0.0112) and 3 years (74% vs. 59%; p = 0.0138). For individual symptoms, STN‐DBS was preferable for eye involvement (81% vs. 56%; p = 0.0255), whereas targeting the GPi (GPi‐DBS) was better for axis symptoms, especially for the trunk (82% vs. 94%; p = 0.015). STN‐DBS was also favorable for generalized dystonia at 36‐month follow‐up (p = 0.04) and required less electrical energy (p < 0.0001). Disability, quality of life, and depression and anxiety measures were also improved. Neither target influenced cognition.

Conclusions

We demonstrated that the GPi and STN are safe and effective targets for isolated dystonia. The STN has the benefits of fast action and low battery consumption, and is superior for ocular dystonia and generalized dystonia, while the GPi is better for trunk involvement. These findings may offer guidance for future DBS target selection for different types of dystonia.
Impact of weight gain with dolutegravir on antiretroviral adherence and viral suppression in four African countries
Authors: Romo Matthew L. , Esber Allahna L. , Owuoth John , Maswai Jonah , Sing'oei Valentine , Iroezindu Michael , Bahemana Emmanuel , Kibuuka Hannah , Cavanaugh J. Sean , Shah Neha , Ake Julie A. , Crowell Trevor A. ,   the AFRICOS Study Group
Published: May 2023

Objective

We hypothesized that total body weight (TBW) gain after switching antiretroviral therapy (ART) regimen to tenofovir disoproxil fumarate/lamivudine/dolutegravir (TLD) may negatively impact ART adherence and viral load (VL) and therefore sought to examine these associations.

Methods

The ongoing African Cohort Study (AFRICOS) enrols people with HIV at 12 facilities in Kenya, Nigeria, Tanzania and Uganda supported by The US President's Emergency Plan for AIDS Relief. Among ART‐experienced participants who switched to TLD, we used multivariable multinomial logistic regression to examine associations between pre−/post‐TLD changes in percentage TBW (≥5% gain, <5% change, ≥5% loss) and changes in self‐reported ART adherence (0, 1–2, ≥3 days missed doses in past 30 days) and VL [(<50 copies/mL (undetectable), 50–999 copies/mL (detectable, but suppressed), ≥1000 copies/mL (unsuppressed)].

Results

Among 1508 participants, median time from starting TLD to follow‐up was 9 months (interquartile range: 7–11). Overall, 438 (29.1%) participants experienced a TBW gain ≥5%, which was more common among females than among males (32.2% vs 25.2%, p = 0.005) and participants switching from efavirenz [32.0% vs nevirapine (19.9%) and boosted protease inhibitor (20.0%); p < 0.001]. Compared with a TBW change <5% [950 (63.0%) participants], TBW gain ≥5% was not significantly associated with more days with missed ART doses [adjusted odds ratio (aOR) = 0.77, 95% confidence interval (CI): 0.48–1.23] or VL becoming detectable and/or unsuppressed (aOR = 0.69, 95% CI: 0.41–1.16).

Conclusions

Although a substantial proportion of participants experienced weight gain after switching to TLD, we did not identify a significant impact on adherence or virological outcomes.
The effect of Salix alba L. bark extract on dark circles in vitro and in vivo
Authors: Jeon Suwon , Yoon Sohyun , Kim Yuna , Shin Seoungwoo , Ji Hyanggi , Cho Eunae , Park Deokhoon , Jung Eunsun
Published: May 2023

Objective

Dark circles in the infraorbital area are a common cosmetic concern among individuals because they exhibit fatigue and are undesirable across all ages. Of the dark circle etiologies, blood stasis by poor‐vascular integrity can cause darkening of the lower eyelid skin, which might be alleviated by reduced endothelial permeability. In this study, we investigated the effects of Salix alba bark extract (SABE) on the synthesis of hyaluronic acid (HA) in fibroblasts and vascular integrity protection from inflammatory cytokine. We also performed a clinical trial investigating the effect of SABE on dark circles.

Methods

To confirm the effect of SABE on HA synthesis in human dermal fibroblasts (HDFs), we performed ELISA and real‐time PCR. We investigated the interaction HDF‐secreted substance with vascular integrity, and human dermal microvascular endothelial cells (HMEC‐1) were treated with conditioned medium (CM) from HDF treated with or without SABE. Subsequently, we conducted a clinical study on 29 subjects by having them apply SABE containing cream for 8 weeks.

Results

Salix alba bark extract treatment increased HA synthesis and regulated HMW–HA‐related gene expressions in HDF. CM from SABE‐treated HDF alleviated endothelial permeability and led to improved vascular integrity in HMEC‐1 cells. Treatment with the cream containing 2% SABE for 8 weeks improved the parameters measuring dark circles, skin microcirculation and elasticity.

Conclusion

Our results showed that SABE could protect against dark circles in vitro, and that topical treatment of SABE improved the clinical indexes of dark circles in a clinical study. Therefore, SABE can be used as an active ingredient for improving dark circles.
Thirty years of International Transactions in Operational Research: past, present, and future direction
Authors: Akpan Ikpe Justice
Published: May 2023

The journal “International Transactions in Operational Research” (ITOR) marks its 30th anniversary this year. This study undertakes the first bibliometrics analysis of ITOR covering the past 30 years (1994–2023). Utilizing metadata from 1835 articles published in the journal, this article evaluates ITOR’s intellectual, conceptual, and social structures. The study highlights several exciting outcomes: First, the literature publication trend shows sustained growth and increased articles’ publication and citation impacts. Second, the analysis of the intellectual structure using co‐citation analysis and text analytics identified a solid collaborative relationship with core sources in operations research and management science and applications. Third, the conceptual evaluation using the co‐occurrence of keywords as the unit of analysis identifies the thematic trends of publications in ITOR. Finally, the social structures, which focused on country collaborations and literature contributions dynamics and impacts, offer insights into future directions to maintaining or strategizing a global focus for the Journal.
Hybrid double‐dermal flap technique for vest‐over‐pants‐closure correction of depressed abdominal scars
Authors: Gelidan Adnan G.
Published: May 2023

Surgical procedures performed during neonatal period or childhood that result in vertical midline, transverse left upper quadrant, or central upper abdominal scars create significant psychological concerns in adulthood. Various surgical techniques correct depressed scars, including scar revision, Z‐ or W‐plasty flaps, sub‐incision tunnelling, fat grafting, and autologous or alloplastic dermal grafting. This article describes a novel technique for repairing depressed abdominal scars using hybrid double‐dermal flaps. We included patients with psychosocial concerns who underwent abdominal scar revision because of wedding plans. Hybrid local de‐epithelised dermal flaps were used to correct the depression of the abdominal scar. Superior and inferior skin flaps, medial and lateral to the depressed scar, were de‐epithelised for 2 to 3 cm and sutured using the vest‐over‐pants technique with 2/0 nylon permanent sutures. Six female patients who want to marry were included in this study. Depressed abdominal scars were successfully fixed using hybrid double‐dermal flaps, either from the superior‐inferior aspect for transverse scars or from the medial‐lateral aspect for vertical scars. No postoperative complications were noted, and the patients were satisfied with the outcomes. De‐epithelialised double‐dermal flaps in the vest‐over‐pants technique are an effective and valuable surgical technique for correcting depressed scars.