bluuebunny/crossref_metadata_2025 huggingface dataset:
CCC- and WASH-mediated endosomal sorting of LDLR is required for normal clearance of circulating LDL
Authors: Bartuzi Paulina , Billadeau Daniel D. , Favier Robert , Rong Shunxing , Dekker Daphne , Fedoseienko Alina , Fieten Hille , Wijers Melinde , Levels Johannes H. , Huijkman Nicolette , Kloosterhuis Niels , van der Molen Henk , Brufau Gemma , Groen Albert K. , Elliott Alison M. , Kuivenhoven Jan Albert , Plecko Barbara , Grangl Gernot , McGaughran Julie , Horton Jay D. , Burstein Ezra , Hofker Marten H. , van de Sluis Bart
Published: March 2016

The low-density lipoprotein receptor (LDLR) plays a pivotal role in clearing atherogenic circulating low-density lipoprotein (LDL) cholesterol. Here we show that the COMMD/CCDC22/CCDC93 (CCC) and the Wiskott–Aldrich syndrome protein and SCAR homologue (WASH) complexes are both crucial for endosomal sorting of LDLR and for its function. We find that patients with X-linked intellectual disability caused by mutations in CCDC22 are hypercholesterolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma LDL cholesterol levels. Furthermore, Commd1 depletion results in mislocalization of LDLR, accompanied by decreased LDL uptake. Increased total plasma cholesterol levels are also seen in hepatic COMMD9-deficient mice. Inactivation of the CCC-associated WASH complex causes LDLR mislocalization, increased lysosomal degradation of LDLR and impaired LDL uptake. Furthermore, a mutation in the WASH component KIAA0196 (strumpellin) is associated with hypercholesterolaemia in humans. Altogether, this study provides valuable insights into the mechanisms regulating cholesterol homeostasis and LDLR trafficking.
Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis
Authors: Leppkes Moritz , Maueröder Christian , Hirth Sebastian , Nowecki Stefanie , Günther Claudia , Billmeier Ulrike , Paulus Susanne , Biermann Mona , Munoz Luis E. , Hoffmann Markus , Wildner Dane , Croxford Andrew L. , Waisman Ari , Mowen Kerri , Jenne Dieter E. , Krenn Veit , Mayerle Julia , Lerch Markus M. , Schett Georg , Wirtz Stefan , Neurath Markus F. , Herrmann Martin , Becker Christoph
Published: March 2016

Ductal occlusion has been postulated to precipitate focal pancreatic inflammation, while the nature of the primary occluding agents has remained elusive. Neutrophils make use of histone citrullination by peptidyl arginine deiminase-4 (PADI4) in contact to particulate agents to extrude decondensed chromatin as neutrophil extracellular traps (NETs). In high cellular density, NETs form macroscopically visible aggregates. Here we show that such aggregates form inside pancreatic ducts in humans and mice occluding pancreatic ducts and thereby driving pancreatic inflammation. Experimental models indicate that PADI4 is critical for intraductal aggregate formation and that PADI4-deficiency abrogates disease progression. Mechanistically, we identify the pancreatic juice as a strong instigator of neutrophil chromatin extrusion. Characteristic single components of pancreatic juice, such as bicarbonate ions and calcium carbonate crystals, induce aggregated NET formation. Ductal occlusion by aggregated NETs emerges as a pathomechanism with relevance in a plethora of inflammatory conditions involving secretory ducts.
Effective energy storage from a triboelectric nanogenerator
Authors: Zi Yunlong , Wang Jie , Wang Sihong , Li Shengming , Wen Zhen , Guo Hengyu , Wang Zhong Lin
Published: March 2016

To sustainably power electronics by harvesting mechanical energy using nanogenerators, energy storage is essential to supply a regulated and stable electric output, which is traditionally realized by a direct connection between the two components through a rectifier. However, this may lead to low energy-storage efficiency. Here, we rationally design a charging cycle to maximize energy-storage efficiency by modulating the charge flow in the system, which is demonstrated on a triboelectric nanogenerator by adding a motion-triggered switch. Both theoretical and experimental comparisons show that the designed charging cycle can enhance the charging rate, improve the maximum energy-storage efficiency by up to 50% and promote the saturation voltage by at least a factor of two. This represents a progress to effectively store the energy harvested by nanogenerators with the aim to utilize ambient mechanical energy to drive portable/wearable/implantable electronics.
An organizing principle for two-dimensional strongly correlated superconductivity
Authors: Fratino L. , Sémon P. , Sordi G. , Tremblay A.-M. S.
Published: March 2016

Superconductivity in the cuprates exhibits many unusual features. We study the two-dimensional Hubbard model with plaquette dynamical mean-field theory to address these unusual features and relate them to other normal-state phenomena, such as the pseudogap. Previous studies with this method found that upon doping the Mott insulator at low temperature a pseudogap phase appears. The low-temperature transition between that phase and the correlated metal at higher doping is first-order. A series of crossovers emerge along the Widom line extension of that first-order transition in the supercritical region. Here we show that the highly asymmetric dome of the dynamical mean-field superconducting transition temperature "Equation missing", the maximum of the condensation energy as a function of doping, the correlation between maximum "Equation missing" and normal-state scattering rate, the change from potential-energy driven to kinetic-energy driven pairing mechanisms can all be understood as remnants of the normal state first-order transition and its associated crossovers that also act as an organizing principle for the superconducting state.
GIS-NaP1 zeolite microspheres as potential water adsorption material: Influence of initial silica concentration on adsorptive and physical/topological properties
Authors: Sharma Pankaj , Song Ju-Sub , Han Moon Hee , Cho Churl-Hee
Published: March 2016

GIS-NaP1 zeolite samples were synthesized using seven different Si/Al ratios (5–11) of the hydrothermal reaction mixtures having chemical composition Al2O3:xSiO2:14Na2O:840H2O to study the impact of Si/Al molar ratio on the water vapour adsorption potential, phase purity, morphology and crystal size of as-synthesized GIS-NaP1 zeolite crystals. The X-ray diffraction (XRD) observations reveal that Si/Al ratio does not affect the phase purity of GIS-NaP1 zeolite samples as high purity GIS-NaP1 zeolite crystals were obtained from all Si/Al ratios. Contrary, Si/Al ratios have remarkable effect on the morphology, crystal size and porosity of GIS-NaP1 zeolite microspheres. Transmission electron microscopy (TEM) evaluations of individual GIS-NaP1 zeolite microsphere demonstrate the characteristic changes in the packaging/arrangement, shape and size of primary nano crystallites. Textural characterisation using water vapour adsorption/desorption, and nitrogen adsorption/desorption data of as-synthesized GIS-NaP1 zeolite predicts the existence of mix-pores i.e., microporous as well as mesoporous character. High water storage capacity 1727.5 cm3 g−1 (138.9 wt.%) has been found for as-synthesized GIS-NaP1 zeolite microsphere samples during water vapour adsorption studies. Further, the total water adsorption capacity values for P6 (1299.4 mg g−1) and P7 (1388.8 mg g−1) samples reveal that these two particular samples can absorb even more water than their own weights.
Fluid dynamic lateral slicing of high tensile strength carbon nanotubes
Authors: Vimalanathan Kasturi , Gascooke Jason R. , Suarez-Martinez Irene , Marks Nigel A. , Kumari Harshita , Garvey Christopher J. , Atwood Jerry L. , Lawrance Warren D. , Raston Colin L.
Published: March 2016

Lateral slicing of micron length carbon nanotubes (CNTs) is effective on laser irradiation of the materials suspended within dynamic liquid thin films in a microfluidic vortex fluidic device (VFD). The method produces sliced CNTs with minimal defects in the absence of any chemical stabilizers, having broad length distributions centred at ca 190, 160 nm and 171 nm for single, double and multi walled CNTs respectively, as established using atomic force microscopy and supported by small angle neutron scattering solution data. Molecular dynamics simulations on a bent single walled carbon nanotube (SWCNT) with a radius of curvature of order 10 nm results in tearing across the tube upon heating, highlighting the role of shear forces which bend the tube forming strained bonds which are ruptured by the laser irradiation. CNT slicing occurs with the VFD operating in both the confined mode for a finite volume of liquid and continuous flow for scalability purposes.
miR-434-3p and DNA hypomethylation co-regulate eIF5A1 to increase AChRs and to improve plasticity in SCT rat skeletal muscle
Authors: Shang Fei-Fei , Xia Qing-Jie , Liu Wei , Xia Lei , Qian Bao-Jiang , You Ling , He Mu , Yang Jin-Liang , Wang Ting-Hua
Published: March 2016

Acetylcholine receptors (AChRs) serve as connections between motor neurons and skeletal muscle and are essential for recovery from spinal cord transection (SCT). Recently, microRNAs have emerged as important potential biotherapeutics for several diseases; however, whether miRNAs operate in the modulation of AChRs remains unknown. We found increased AChRs numbers and function scores in rats with SCT; these increases were reduced following the injection of a eukaryotic translation initiation factor 5A1 (eIF5A1) shRNA lentivirus into the hindlimb muscle. Then, high-throughput screening for microRNAs targeting eIF5A1 was performed, and miR-434-3p was found to be robustly depleted in SCT rat skeletal muscle. Furthermore, a highly conserved miR-434-3p binding site was identified within the mRNA encoding eIF5A1 through bioinformatics analysis and dual-luciferase assay. Overexpression or knockdown of miR-434-3p in vivo demonstrated it was a negative post-transcriptional regulator of eIF5A1 expression and influenced AChRs expression. The microarray-enriched Gene Ontology (GO) terms regulated by miR-434-3p were muscle development terms. Using a lentivirus, one functional gene (map2k6) was confirmed to have a similar function to that of miR-434-3p in GO terms. Finally, HRM and MeDIP-PCR analyses revealed that DNA demethylation also up-regulated eIF5A1 after SCT. Consequently, miR-434-3p/eIF5A1 in muscle is a promising potential biotherapy for SCI repair.
Structural health monitoring (vibration) as a tool for identifying structural alterations of the lumbar spine: a twin control study
Authors: Kawchuk Gregory N. , Hartvigsen Jan , Edgecombe Tiffany , Prasad Narasimha , van Dieen Jaap H.
Published: March 2016

Structural health monitoring (SHM) is an engineering technique used to identify mechanical abnormalities not readily apparent through other means. Recently, SHM has been adapted for use in biological systems, but its invasive nature limits its clinical application. As such, the purpose of this project was to determine if a non-invasive form of SHM could identify structural alterations in the spines of living human subjects. Lumbar spines of 10 twin pairs were visualized by magnetic resonance imaging then assessed by a blinded radiologist to determine whether twin pairs were structurally concordant or discordant. Vibration was then applied to each subject’s spine and the resulting response recorded from sensors overlying lumbar spinous processes. The peak frequency, area under the curve and the root mean square were computed from the frequency response function of each sensor. Statistical analysis demonstrated that in twins whose structural appearance was discordant, peak frequency was significantly different between twin pairs while in concordant twins, no outcomes were significantly different. From these results, we conclude that structural changes within the spine can alter its vibration response. As such, further investigation of SHM to identify spinal abnormalities in larger human populations is warranted.
Optical responses of a metal with sub-nm gaps
Authors: Park Sang Jun , Kim Tae Yun , Park Cheol-Hwan , Kim Dai-Sik
Published: March 2016

If the size of a metallic structure is reduced to be comparable to or even smaller than the typical quantum-mechanical lengths such as the Fermi wavelength or Thomas-Fermi wavelength, the electronic structure and optical responses are modulated by quantum effects. Here, we calculate the optical responses of a metal with sub-nm gaps using the eigenstates obtained from an effective-mass quantum theory. According to our simulation, the dielectric responses can be significantly modified by tuning the inter-gap distances. Remarkably, sub-nm gaps occupying a 0.3% volumetric fraction can elongate the penetration depth by an order of magnitude in the terahertz regime. We find that the detailed dependences of electron-photon interaction matrix elements on the involved electronic wavefunctions play an important role in the optical responses. The results draw our attention to these recently fabricated systems.
Polarization induced Z2 and Chern topological phases in a periodically driving field
Authors: Pi Shu-Ting , Savrasov Sergey
Published: March 2016

Z2 and Chern topological phases such as newly discovered quantum spin Hall and original quantum Hall states hardly both co–exist in a single material due to their contradictory requirement on the time–reversal symmetry (TRS). We show that although the TRS is broken in systems with a periodically driving field, an effective TRS can still be defined provided the ac–field is linearly polarized or certain other conditions are satisfied. The controllable TRS provides us a route to manipulate contradictory phases by tuning the polarization. To demonstrate the idea, we consider a tight-binding model that is relevant to several monolayered materials as a benchmark system. Our calculation shows not only topological Z2 to Chern phase transition occurs but rich Chern phases are also observed. In addition, we also discussed the realization of our proposal in real materials, such as spin-orbit coupled graphene and crystal Bismuth. This opens the possibility of manipulating various topological phases in a single material and can be a promising approach to engineer new electronic states of matter.
Abrupt climate shift in the Western Mediterranean Sea
Authors: Schroeder K. , Chiggiato J. , Bryden H. L. , Borghini M. , Ben Ismail S.
Published: March 2016

One century of oceanographic measurements has evidenced gradual increases in temperature and salinity of western Mediterranean water masses, even though the vertical stratification has basically remained unchanged. Starting in 2005, the basic structure of the intermediate and deep layers abruptly changed. We report here evidence of reinforced thermohaline variability in the deep western basin with significant dense water formation events producing large amounts of warmer, saltier and denser water masses than ever before. We provide a detailed chronological order to these changes, giving an overview of the new water masses and following their route from the central basin interior to the east (toward the Tyrrhenian) and toward the Atlantic Ocean. As a consequence of this climate shift, new deep waters outflowing through Gibraltar will impact the North Atlantic in terms of salt and heat input. In addition, modifications in the Mediterranean abyssal ecosystems and biogeochemical cycles are to be expected.
A Simple Geotracer Compositional Correlation Analysis Reveals Oil Charge and Migration Pathways
Authors: Yang Yunlai , Arouri Khaled
Published: March 2016

A novel approach, based on geotracer compositional correlation analysis is reported, which reveals the oil charge sequence and migration pathways for five oil fields in Saudi Arabia. The geotracers utilised are carbazoles, a family of neutral pyrrolic nitrogen compounds known to occur naturally in crude oils. The approach is based on the concept that closely related fields, with respect to filling sequence, will show a higher carbazole compositional correlation, than those fields that are less related. That is, carbazole compositional correlation coefficients can quantify the charge and filling relationships among different fields. Consequently, oil migration pathways can be defined based on the established filling relationships. The compositional correlation coefficients of isomers of C1 and C2 carbazoles, and benzo[a]carbazole for all different combination pairs of the five fields were found to vary extremely widely (0.28 to 0.94). A wide range of compositional correlation coefficients allows adequate differentiation of separate filling relationships. Based on the established filling relationships, three distinct migration pathways were inferred, with each apparently being charged from a different part of a common source kitchen. The recognition of these charge and migration pathways will greatly aid the search for new accumulations.
Fast and efficient method for molecular weight analysis of cellulose pulp, in-process and finished product
Authors: Patkar Satish N. , Panzade Prasad D.
Published: March 2016

The purpose of this study is to establish a method for molecular weight analysis of cellulose pulp using fewer GPC columns, with shorter analysis time and lower cost of analysis using HPLC, which is applicable in processing or manufacturing units.
A novel biosensor nanomaterial for the ultraselective and ultrasensitive electrochemical diagnosis of the breast cancer-related BRCA1 gene
Authors: Kazerooni Hanif , Nassernejad Bahram
Published: March 2016

Supramolecular ionic liquids grafted on nitrogen-doped graphene aerogels (SIL-g-(N)GAs) were used as a novel electrochemical DNA biosensor for the direct detection of the breast cancer-related BRCA1 gene.
Pt/WO3/FTO memristive devices with recoverable pseudo-electroforming for time-delay switches in neuromorphic computing
Authors: Shi Tuo , Yin Xue-Bing , Yang Rui , Guo Xin
Published: March 2016

A recoverable pseudo-electroforming process was discovered in Pt/WO3/FTO devices.
Effects of Fe cations in ruthenium-complex multilayers fabricated by a layer-by-layer method
Authors: Oyama Makiko , Ozawa Hiroaki , Nagashima Takumi , Haga Masa-aki , Ishida Takao
Published: March 2016

Molecular multilayers were fabricated using a Ru complex containing Fe cations on an indium tin oxide surface to control the properties of the Ru-complex multilayers such as the multilayer orientation and the electron transport.
Structural effects of a carbon matrix in non-precious metal O2-reduction electrocatalysts
Authors: He Wenhui , Wang Ying , Jiang Chunhuan , Lu Lehui
Published: March 2016

The unique geometric and electronic structural effects of a carbon matrix in several typical non-precious metal O2-reduction electrocatalysts are discussed.
Preparation of nanoliposome loaded with peanut peptide fraction: stability and bioavailability
Authors: Gong Kui-Jie , Shi Ai-Min , Liu Hong-Zhi , Liu Li , Hu Hui , Yang Ying , Adhikari Benu , Wang Qiang
Published: March 2016

Nanoliposome loaded with peanut peptide fraction (PPF) prepared by high pressure microfluidization (HPM) treatment was investigated as well as its stability and bioavailability.
Sustainable oxidations with air mediated by gallic acid: potential applicability in the reutilization of grape pomace
Authors: Scoccia Jimena , Perretti Marcelle D. , Monzón Diego M. , Crisóstomo Fernando P. , Martín Víctor S. , Carrillo Romen
Published: March 2016

Tannins like gallic acid and even grape pomace extract are able to perform oxidations with air thus unleashing an alternative method for reutilization and valorization of bio-wastes.
A lipidomics investigation into the intervention of celastrol in experimental colitis
Authors: Wang Renping , Gu Xueqin , Dai Weiquan , Ye Jun , Lu Feng , Chai Yifeng , Fan Guorong , Gonzalez Frank J. , Duan Gengli , Qi Yunpeng
Published: March 2016

Celastrol significantly alleviated DSS-induced colitis in mice. Lipidomics highlights alteration of several lipid markers associated with colitis. Celastrol treatment recovered SCD1 expression and restored the levels of lipid markers.
Recent progress in fabrication techniques of graphene nanoribbons
Authors: Xu Wentao , Lee Tae-Woo
Published: March 2016

Recent advances in GNR production strategies have been reviewed with a focus on mass production processes.
Electrocatalytic oxidation of ethanol on a glassy carbon electrode modified with a gold nanoparticle-coated hydrolyzed CaFe–Cl layered double hydroxide in alkaline medium
Authors: Taei Masoumeh , Havakeshian Elahe , Salavati Hossein , Abedi Fardin
Published: March 2016

The Ca–Fe–Cl LDH was synthesized by a co-precipitation method in alkaline medium.
Density functional theory approach to CO2 adsorption on a spinel mineral: determination of binding coordination
Authors: Moon Hye Sook , Kwon Soonchul , Kwon Sung Hyun , Cho Min , Seo Jeong Gil , Lee Seung Geol
Published: March 2016

Adsorption mechanisms of CO2 on MgAl2O4 (100) surface.
Modeling and optimizing the performance of PVC/PVB ultrafiltration membranes using supervised learning approaches
Authors: Chi Lina , Wang Jie , Chu Tianshu , Qian Yingjia , Yu Zhenjiang , Wu Deyi , Zhang Zhenjia , Jiang Zheng , Leckie James O.
Published: March 2016

A systematic data analytics framework is developed based on supervised learning (SL), which is used to optimize poly(vinyl chloride) (PVC) and polyvinyl butyral (PVB) blend ultrafiltration membranes fabricatedviadry/wet phase inversion.
Differential influence of additives on the various stages of insulin aggregation
Authors: Saha Shivnetra , Sharma Anurag , Deep Shashank
Published: March 2016

The different species in the aggregation pathway of insulin are stabilized/destabilized to different extent in the presence of various additives.
Theoretical and experimental investigations of the Li storage capacity in single-walled carbon nanotube bundles
Authors: Ramos-Sanchez G. , Chen G. , Harutyunyan A. R. , Balbuena P. B.
Published: March 2016

Lithium stored in interstitial sites reflects the actual low capacity observed from the 2nd cycle and beyond.
Preparation and electromagnetic wave absorption properties of FeNi3 nanoalloys generated on graphene–polyaniline nanosheets
Authors: Ding Xiao , Huang Ying , Li Suping , Wang Jianguo
Published: March 2016

The ternary nanocomposites of rGO–PANI–FeNi3 were successfully synthesized by combining polymerization with hydrothermal reduction reaction.
A pH-driven molecular shuttle based on rotaxane-bridged periodic mesoporous organosilicas with responsive release of guests
Authors: Gao Meng , Han Shuhua , Hu Yongfeng , Dynes James J. , Liu Xiangguo , Wang Dongniu
Published: March 2016

A pH-driven molecular shuttle was immobilized into the framework of the PMOs in which the β-CDs could shuttle mechanically.
Influence of polyvinylpyrrolidone (PVP) capping layer on silver nanowire networks: theoretical and experimental studies
Authors: Hwang Jinyoung , Shim Youngseon , Yoon Seon-Mi , Lee Sang Hyun , Park Sung-Hoon
Published: March 2016

By adjusting the polyvinylpyrrolidone (PVP) capping layer thickness on silver nanowire networks, improved electrical and optical properties were obtained, which was confirmed both experimentally and theoretically (Molecular dynamics and Monte Carlo simulations).
Enhanced hepatic-targeted delivery via oral administration using nanoliposomes functionalized with a novel DSPE–PEG–cholic acid conjugate
Authors: Li Ying , Zhu Chunyan
Published: March 2016

DSPE–PEG–cholic acid modified nanoliposomes interacted with cholic acid receptor on intestine epithelial cells and hepatocytes specifically for oral hepatic targeting.
Design of core–shell magnetic mesoporous silica hybrids for pH and UV light stimuli-responsive cargo release
Authors: Santha Moorthy Madhappan , Kim Hak-Bong , Bae Jae-Ho , Kim Sun-Hee , Ha Chang-Sik
Published: March 2016

The drug carrier system proposed here efficiently works under UV light and pH triggers for controlled release of model cargoes. The nanocarrier can be used in the targeted delivery of cargoes by the ‘ON’ and ‘OFF’ command by the UV light trigger.
Gravitational collapse of depletion-induced colloidal gels
Authors: Harich R. , Blythe T. W. , Hermes M. , Zaccarelli E. , Sederman A. J. , Gladden L. F. , Poon W. C. K.
Published: March 2016

We study the ageing and ultimate gravitational collapse of colloidal gels in which the interparticle attraction is induced by non-adsorbing polymers via the depletion effect.
A colorimetric and fluorescent dual probe for palladium in aqueous medium and live cell imaging
Authors: Yan Jin-wu , Wang Xiao-lin , Tan Qi-feng , Yao Pei-fen , Tan Jia-heng , Zhang Lei
Published: March 2016

A colorimetric and fluorescent dual probe for palladium species was rationally developed by combining the resorufin fluorophore with allyl chloroformate.
A near-infrared fluorescent aza-bodipy probe for dual-wavelength detection of hydrogen peroxide in living cells
Authors: Xu Jingjing , Zhai Jingying , Xu Yanmei , Zhu Jingwei , Qin Yu , Jiang Dechen
Published: March 2016

A boronic acid functionalized aza-borondipyrromethene dye (azaBDPBA) was applied to the dual-wavelength detection of hydrogen peroxide with high selectivity, which was loaded into cells to indicate the alteration of intracellular hydrogen peroxide during biological processes.
Cell-free compartmentalized protein synthesis inside double emulsion templated liposomes with in vitro synthesized and assembled ribosomes
Authors: Caschera Filippo , Lee Jin Woo , Ho Kenneth K. Y. , Liu Allen P. , Jewett Michael C.
Published: March 2016

A cell-free expression platform for making bacterial ribosomes encapsulated within giant liposomes was capable of synthesizing sfGFP.
Boosting the photocatalytic performance of (001) BiOI: enhancing donor density and separation efficiency of photogenerated electrons and holes
Authors: Fan Wenjie , Li Haibo , Zhao Fengyi , Xiao Xujing , Huang Yongchao , Ji Hongbing , Tong Yexiang
Published: March 2016

BiOI nanosheets with highly exposed (001) and surface disorders are used for efficient photocatalytic HCHO oxidation under visible light irradiation.
Synthesis of covalently bonded boron-dipyrromethene–diarylethene for building a stable photosensitizer with photo-controlled reversibility
Authors: Hu Qiao-Ju , Lu Yu-Chen , Yang Cheng-Xiong , Yan Xiu-Ping
Published: March 2016

A novel covalently bonded aza-boron-dipyrromethene–diarylethene photosensitizer was prepared for reversible photo-controlled singlet oxygen generation.
K+-Induced in situ self-assembly of near-infrared luminescent membrane material armored with bigger Yb(iii) complex crystallites
Authors: Chen Wanmin , Tang Xiaoliang , Dou Wei , Ju Zhenghua , Xu Benhua , Xu Wenxuan , Liu Weisheng
Published: March 2016

A semi-rigid ligand could capture effectively Yb3+ ions to form a stable Yb3+ complex and provide a potential cavity to accommodate alkali metal ions.
Towards understanding the improved stability of palladium supported on TS-1 for catalytic combustion
Authors: Setiawan Adi , Friggieri Jarrod , Hosseiniamoli Hadi , Kennedy Eric M. , Dlugogorski Bogdan Z. , Adesina Adesoji A. , Stockenhuber Michael
Published: March 2016

A novel TS-1 supported Pd catalyst was synthesized and tested in methane combustion under very lean (<1%) and humid conditions.
A designed lipopeptide with a leucine zipper as an imbedded on/off switch for lipid bilayers
Authors: Wang Sijia , Shen Yinxing , Zhang Junqi , Xu Shouhong , Liu Honglai
Published: March 2016

As a drug carrier, a liposome containing zipper-type lipopeptide achieves reversible and highly controlled release by thermo-stimulation.
Multiscale computational modeling of 13C DNP in liquids
Authors: Küçük Sami Emre , Sezer Deniz
Published: March 2016

Quantitative prediction of 13C DNP coupling factors is achieved for acetone in water and pure chloroform.
Planar vs. three-dimensional X62−, X2Y42−, and X3Y32− (X, Y = B, Al, Ga) metal clusters: an analysis of their relative energies through the turn-upside-down approach
Authors: El Bakouri Ouissam , Solà Miquel , Poater Jordi
Published: March 2016

Despite the fact that B and Al belong to the same group 13 elements, the B62− cluster prefers the planar D2h geometry, whereas Al62− favours the Oh structure, which is caused by orbital interactions.
Improved synthesis and hydrothermal stability of Pt/C catalysts based on size-controlled nanoparticles
Authors: Lemus J. , Bedia J. , Calvo L. , Simakova I. L. , Murzin D. Yu. , Etzold B. J. M. , Rodriguez J. J. , Gilarranz M. A.
Published: March 2016

A novel method for the preparation of stable Pt/C catalysts with size-controlled nanoparticles has been developed.
Cyclopentadienyl nickel(ii) N,C-chelating benzothiazolyl NHC complexes: synthesis, characterization and application in catalytic C–C bond formation reactions
Authors: Teo Wei Jie , Wang Zhe , Xue Fei , Andy Hor T. S. , Zhao Jin
Published: March 2016

CpNi(ii) N,C-chelating benzothiazolyl NHC complexes have been synthesized. They are efficient catalysts for the homo-coupling of benzyl bromide in the presence of MeMgCl at r.t. with good function group tolerance.
Gold nanotriangles decorated with superparamagnetic iron oxide nanoparticles: a compositional and microstructural study
Authors: Hachtel J. A. , Yu S. , Lupini A. R. , Pantelides S. T. , Gich M. , Laromaine A. , Roig A.
Published: March 2016

The combination of iron oxide and gold in a single nanoparticle results in both magnetic and plasmonic properties that can stimulate novel applications in bio-sensing, medical imaging, or therapeutics. Microwave assisted heating allows the fabrication of multi-component, multi-functional nanostructures by promoting selective heating at desired sites. Recently, we reported a microwave-assisted polyol route yielding gold nanotriangles decorated with iron oxide nanoparticles. Here, we present an in-depth microstructural and compositional characterization of the system using scanning transmission electron microscopy (STEM) and electron energy loss spectroscopy (EELS). A method to remove the iron oxide nanoparticles from the gold nanocrystals and some insights on crystal nucleation and growth mechanisms are also provided.
Monodisperse polyethylene glycol diacrylate hydrogel microsphere formation by oxygen-controlled photopolymerization in a microfluidic device
Authors: Krutkramelis K. , Xia B. , Oakey J.
Published: March 2016

There is widespread interest in microfabricated PEG-based hydrogels as drug delivery and tissue scaffolding materials. A nitrogen micro-jacketed microfluidic device is presented for the the continuous on-chip photopolymerization of microscale PEGDA particles.
Synthesis of decahydropyrrolo[1,2-a]tetrazolo[1,5-d]pyrazines via Strecker reaction and intramolecular [3+2] cycloaddition
Authors: Afraj Shakil N. , Chen Chinpiao , Lee Gene-Hsian
Published: March 2016

An efficient method for synthesizing a series of novel (5aS,10R)-10-aryl-5,5a,6,7,8,10-hexahydropyrrolo[1,2-a]tetrazolo[1,5-d]pyrazines by using a catalyst-free three-component Strecker reaction followed by an intramolecular [3+2] cycloaddition.
Stereo-chemical contributions to the glass transition and liquid–liquid phase separation in high molecular weight poly(N-vinyl carbazole)
Authors: Al Lafi Abdul G. , Hay James N.
Published: March 2016

Thermal history and purification effects on the structural properties of PVK were investigated. Liquid–liquid phase separation is suggested to occur by separation of isotactic rich segments from a matrix which is predominantly atactic.
Exploring the role of a single water molecule in the tropospheric reaction of glycolaldehyde with an OH radical: a mechanistic and kinetics study
Authors: Kaur Ramanpreet , Vikas Vikas
Published: March 2016

This work reveals that though a single-water molecule decelerates the atmospheric reaction between the glycolaldehyde and OH radical, however, it facilitates thecis–​transinterconversion along the hydrogen-abstraction pathways.
Synthesis of BiOI nanosheet/coarsened TiO2 nanobelt heterostructures for enhancing visible light photocatalytic activity
Authors: Li Zhanjun , Wang Meiting , Shen Jianxing , Zhu Zhiwen , Liu Yu
Published: March 2016

BiOI nanosheet/coarsened TiO2 nanobelt heterostructure composites (BiOI/TiO2 CNHs) were prepared via an efficient hydrothermal method.
A new concept for electroless nickel plating: aluminium as reducing agent
Authors: Zhang Xingkai , Zhang Junyan
Published: March 2016

Aluminum was used as a reducing agent for preparing nickel coatings with excellent corrosion resistance from electroless plating baths containing no reducing agents.
A highly selective and sensitive acylhydrazone-based turn-on optical sensor for Al3+
Authors: Ma Junchi , Shi Wei , Feng Lei , Chen Yabin , Fan Kui , Hao Yunpeng , Hui Yonghai , Xie Zhengfeng
Published: March 2016

The fluorescence turn-on probing of Al3+ in ethanol was realized by the utilization of a type of conjugated acylhydrazone-based compound.
Comparison of hyper-cross-linked polystyrene/polyacryldiethylenetriamine (HCP/PADETA) interpenetrating polymer networks (IPNs) with hyper-cross-linked polystyrene (HCP): structure, adsorption and separation properties
Authors: Fu Zhenyu , Han Shan , Huang Jianhan , Liu You-Nian
Published: March 2016

HCP/PADETA IPNs can separate salicylic acid efficiently from phenol in a mixed solution.
Catalyst-free and environment friendly synthesis of 2-aryl-3-substituted-4-thiazolidinones in water
Authors: Thakare Manoj P. , Shaikh Rahimullah , Tayade Dipak
Published: March 2016

A simple, efficient, eco-friendly, and cost-effective method has been developed for the three component one pot synthesis of 2-aryl-3-substituted-4-thiazolidinones is described.
Fire retardant sol–gel coatings for flexible polyurethane foams
Authors: Bellayer S. , Jimenez M. , Barrau S. , Bourbigot S.
Published: March 2016

Untreated flexible polyurethane foams used in upholstered products are prone to rapid fire growth. Sol–gel process was evaluated to flame retard it. A successful intumescent formulation gave 60% reduction of the peak of heat release rate.
Non-doped deep blue light-emitting electrochemical cells from charged organic small molecules
Authors: Shanmugasundaram Kanagaraj , Subeesh Madayanad Suresh , Sunesh Chozhidakath Damodharan , Choe Youngson
Published: March 2016

Pure deep-blue light-emitting LEC devices were fabricated utilizing charged organic small molecules. with CIE coordinates of (0.15, 0.09) and (0.16, 0.10) for compound1and compound2, respectively.
α-MoO3/polyaniline composite for effective scavenging of Rhodamine B, Congo red and textile dye effluent
Authors: Dhanavel S. , Nivethaa E. A. K. , Dhanapal K. , Gupta V. K. , Narayanan V. , Stephen A.
Published: March 2016

Polyaniline modified MoO3 composites were synthesized via a chemical oxidative polymerization method and employed as a novel adsorbent for Rhodamine B (RhB), Congo red (CR) and textile dye effluent.
A novel acid-catalyzed rearrangement of 2-substituted-3-(2-nitrophenyl)oxiranes for the synthesis of di- and mono-oxalamides
Authors: Mamedov Vakhid A. , Mamedova Vera L. , Khikmatova Gul'nas Z. , Mironova Ekaterina V. , Krivolapov Dmitry B. , Bazanova Olga B. , Chachkov Denis V. , Katsyuba Sergey A. , Rizvanov Il'dar Kh , Latypov Shamil K.
Published: March 2016

A new acid-catalyzed rearrangement of oxiranes for the syntheses of biologically important pharmaceutical molecules with anthranilic acid and oxalamide moieties has been discovered.
Solvent-controlled formation of a reduced graphite oxide gel via hydrogen bonding
Authors: Liu Yang , Liang Cheng-Lu , Wu Jing-jie , Bao Rui-Ying , Qi Guo-Qiang , Wang Yu , Yang Wei , Xie Bang-Hu , Yang Ming-Bo
Published: March 2016

Hydrogen bonding between solvent molecules and the oxygen-containing functional groups on rGO sheets is vital to achieve high-performance rGO gels.
Is it possible to substitute hexane with green solvents for extraction of carotenoids? A theoretical versus experimental solubility study
Authors: Yara-Varón E. , Fabiano-Tixier A. S. , Balcells M. , Canela-Garayoa R. , Bily Antoine , Chemat F.
Published: March 2016

Evaluation of five green solventsi.e.2-methyltetrahydrofuran (2-MeTHF), dimethyl carbonate (DMC), cyclopentyl methyl ether (CPME), isopropyl alcohol (IPA) and ethyl acetate, for replacing of hexane in extraction of carotenoids from carrots.
Hyperbranched polyethylenimine based polyamine-N-oxide-carboxylate chelates of gadolinium for high relaxivity MRI contrast agents
Authors: Xiong Rulin , Cheng Likun , Tian Yu , Tang Weijun , Xu Kehan , Yuan Yuan , Hu Aiguo
Published: March 2016

Polydentate amine-N-oxide carboxylates were used as ligands for the formation of Gd(iii) complexes with high relaxivity as MRI contrast agents. Cytotoxicity assays revealed good cytocompatibility of these complexes for clinical applications.
Understanding the structural requirements of cyclic sulfone hydroxyethylamines as hBACE1 inhibitors against Aβ plaques in Alzheimer's disease: a predictive QSAR approach
Authors: Ambure Pravin , Roy Kunal
Published: March 2016

Beta (β)-site amyloid precursor protein cleaving enzyme 1 (BACE1) is one of the most important targets in Alzheimer's disease (AD), which is responsible for production and accumulation of beta amyloid (Aβ).
Targeting of the Leishmania mexicana cysteine protease CPB2.8ΔCTE by decorated fused benzo[b]thiophene scaffold
Authors: Scala A. , Micale N. , Piperno A. , Rescifina A. , Schirmeister T. , Kesselring J. , Grassi G.
Published: March 2016

A potent and highly selective anhydride-based inhibitor ofLeishmania mexicanacysteine protease CPB2.8 (IC50= 3.7 μM) was investigated by inhibition assays, NMR biomimetic experiments and docking studies.
N, O-codoped hierarchical porous carbons derived from algae for high-capacity supercapacitors and battery anodes
Authors: Yu Wenhua , Wang Huanlei , Liu Shuang , Mao Nan , Liu Xiao , Shi Jing , Liu Wei , Chen Shougang , Wang Xin
Published: March 2016

Nitrogen and oxygen codoped hierarchical porous carbons have been synthesized by using a direct carbonization/activation procedure of biomass algae – Enteromorpha.
Influence of N-anion-doping on the production and the photoluminescence properties of γ-Ca2SiO4:Ce3+ phosphors and the β → γ phase transformation
Authors: Ji Weiwei , Ye Shifan , Lee Ming-Hsien , Hao Luyuan , Xu Xin , Agathopoulos Simeon , Zheng Dewen , Fang Chaohe , Huang Yuanrui
Published: March 2016

A dramatic shift in the emission from yellow to light-blue was recorded when γ-Ca2SiO4:Ce3+ was heated to 800 °C.
Paraffin wax‐based dielectric lens for metamaterial measurement in the S‐band
Authors: Zarghooni Behnam , Dadgarpour Abdolmehdi , Denidni Tayeb A.
Published: March 2016

In this study, the paraffin wax is used in a moulding process to fabricate two dielectric lenses with the diameter of 24 inches for metamaterial measurement in the S‐band (1–4 GHz) using the free‐space method. The moulding process guarantees the lower cost and ease of implementation compared to the conventional machining procedure. To verify the lens performance, the two fabricated samples are used to measure the S‐parameters of a well‐known spiral metamaterial unit cell. In this process, a three‐dimensional prototype of the unit cell is fabricated and placed between two standard horn antennas facing each other, and the dielectric lenses are used in front of the each horn antenna to ensure that the metamaterial prototype is correctly illuminated by the incident wave. This experiment provides a very good agreement with the simulation and confirms that the lens structure works properly.
Microstrip‐fed complementary Yagi–Uda antenna
Authors: Rodriguez‐Ulibarri Pablo , Bertuch Thomas
Published: March 2016

In this study, a microstrip‐fed complementary Yagi–Uda antenna backed with milled cavities is presented. This antenna is intended to radiate as near as possible to the end‐fire direction while keeping a low profile and small size. The radiator and reflector elements are U‐shaped slots while the director is a rectangular slot. These slots are printed on top of a very thin bendable commercial substrate. The radiator is fed by a microstrip line printed on the bottom side of the substrate. A thick metallic plate in which cavities are milled is placed below the substrate and connected by pin wires to the upper metallisation of the substrate. An S‐band prototype is designed, fabricated and measured providing an operational bandwidth of 3% around 2.44 GHz, a maximum gain of about 8 dBi is achieved in the main beam which points towards 46° away from the broadside direction. Finally, simulation results of array and different conformal configurations are presented demonstrating the advantages of the microstrip feeding and the thin substrate material. Bending of the antenna along H‐plane and E‐plane for different curvatures is evaluated.
Kritik an der Selbstverwaltung
Authors: Gaede Kirsten
Published: March 2016

Die Selbstverwaltung steht derzeit auf dem Prüfstand. Zu diesem Ergebnis kommt der Sachverständigenrat in seinem Gutachten 2005. Skeptisch beurteilt der Rat auch das Pflegesystem.
Auf Sendung
Authors: Mühlnikel Ingrid
Published: March 2016

Der Burda-Verlag geht mit einem eigenen Sender für Gesundheitsthemen an den Start. Mit einem 24-Stunden-Programm will Focus Gesundheit die Zuschauer über Medizinthemen und Gesundheitsförderung informieren, beraten und unterhalten. Zu sehen ist der Spartenkanal auf Premiere.
Unwetter über Süd-England
Authors: Glatzer Ulrich
Published: March 2016

Die Gerüchteküche hatte bereits seit März gebrodelt. Jetzt hat es im Nationalen Programm für IT (NPfIT) im englischen Gesundheitswesen richtig gekracht. In einer spektakulären Aktion hat sich Fujitsu, der für den Süden Englands verantwortliche Serviceprovider, von IDX, seinem zentralen Software-Lieferanten, getrennt. Statt IDX soll nun dem Vernehmen nach der US-amerikanische Anbieter Cerner die dringend benötigten Programmteile liefern.
Auslaufmodell DMP
Authors: Mühlnikel Ingrid
Published: March 2016

Jetzt, wo die DMP so richtig angerollt sind, könnte es sein, dass bei einem Wahlsieg der Union der Zug gestoppt wird. Experten sind sich einig: Die Kopplung an den Risikostrukturausgleich ist teuer und ineffizient.
Arbeitsplatz Europa
Authors: Spielberg Petra
Published: March 2016

Die beruflichen Qualifikationen von über 150 Berufen sollen in jedem Land der EU anerkannt werden. Damit wird die bislang geltende Ärzte- durch die Berufsanerkennungsrichtlinie ersetzt. Der Freizügigkeit werden jedoch Grenzen gesetzt: Neue Facharzttitel werden nicht ohne weiteres akzeptiert.
Hauen und Stechen
Authors: Ghanaat Henrik
Published: March 2016

Auf dem Münchener Klinikmarkt ist der Konkurrenzkampf voll entbrannt. 50 Häuser wetteifern um die Gunst der Patienten. Nach der Fusion der städtischen Kliniken fühlt sich die Kommune für den Wettbewerb gerüstet. Ob zurecht, ist allerdings fraglich: Die privaten Betreiber wollen schon bald weitere Marktanteile erobern.
Alles auf eine Sparte
Authors: Schmidt Hartmut
Published: March 2016

Fresenius hat gute Zahlen vorgelegt. Und der Erwerb der amerikanischen Renal Care Group bringt das Unternehmen auch international besser ins Geschäft. Allerdings: Die Akquisition verstärkt den Einfluss der Sparte FMC auf den Gesamtkonzern.

Künftig dürfte FMC rund 75 Prozent des Gesamtumsatzes erwirtschaften.
Zwang zur Expansion
Authors: Schmidt Hartmut
Published: March 2016

Curanum konnte in den vergangenen Monaten den Ertrag deutlich steigern. Verantwortlich dafür war auch das geringe Wachstum. Und hier liegt der Haken: Curanum muss expandieren, um seine Ziele zu erreichen und die Anleger zufrieden zu stellen.
Verkäufe beflügeln den Kurs
Authors: Schmidt Hartmut
Published: March 2016

Die Marseille-Aktie wird derzeit von Immobilienspekulationen getrieben: Die Anleger hoffen, dass weitere Verkäufe die Liquidität erhöhen. Doch auf lange Sicht muss das Unternehmen seine Ertragsaussichten verbessern. Das Pflegegeschäft muss wachsen, die Reha-Sparte muss zurück in die Gewinnzone.
Wachgeküsst
Authors: Gaede Kirsten
Published: March 2016

Die Rolle der Stationsschwester wird vielerorts noch unterschätzt. Doch Experten warnen: Wenn diese Schlüsselposition nicht vernünftig besetzt ist, bleiben Ziele wie Prozess- und Patientenorientierung Theorie.
Jede vierte Arztrechnung falsch
Authors: Kolbeck Cornelia
Published: March 2016

Die privaten Krankenversicherungen beanstanden immer mehr Arztrechnungen und zahlen sie auch nicht. Ein Grund dafür ist die fast drei Jahrzehnte alte privatärztliche Gebührenordnung: sie bildet moderne Medizin nicht adäquat ab. Die Versicherten bleiben auf den Behandlungskosten sitzen.
MEDICA 2005
Authors: Geisendorf Nicklas
Published: March 2016

Die Medica bricht auch in diesem Jahr alle Rekorde: Die Medica bricht auch in diesem Jahr alle Rekorde. Doch der Trend zum Superlativ kann nicht verbergen, dass die weltgrößte Medizin-Messe einen Umbruch durchmacht. Zahlreiche deutsche Hersteller haben sich von der Leistungsschau zurückgezogen, zahlreiche ausländische Anbieter haben ihre Plätze eingenommen, um Produktezu präsentieren und Geschäftsabschlüsse einzufädeln. Die weltgrößte Medizin-Messe spiegelt die Globalisierung des Marktes – mit ihren Licht- und Schattenseiten.
Der Coup
Authors: Glatzer Ulrich
Published: March 2016

Mit der Übernahme von Helios hat die Fresenius AG nicht nur die Finanzwelt überrascht. Sie hat damit auch den Startschuss gegeben für wirklichen Wettbewerb in der Gesundheitswirtschaft. In der Branche wird nichts mehr sein wie zuvor.
Mehr als eine Oberfläche
Authors: Glatzer Ulrich
Published: March 2016

GWI hat mit der neuen Version seines KIS-Systems Orbis dessen Erscheinungsbild vollständig verändert. Die zusätzlich vereinheitlichte Funktionslogik aller Teil­systeme und aktive Entscheidungsunterstützung sollen die Nutzerakzeptanz erhöhen.
Die Gewinnmaschine
Authors: Gaede Kirsten
Published: March 2016

In Akutkliniken ist die Physiotherapie eine Nebendarstellerin. Das ist an der Uniklinik in Köln anders: Als ausgegliederte GmbH ist die Abteilung über Nacht zum Star geworden. Seit Jahresbeginn hat die Medifitreha bereits eine halbe Million Euro Gewinn erwirtschaftet.
Wettbewerb im Hause des Herrn
Authors: Heuer Claudia
Published: March 2016

Kliniken in konfessioneller Trägerschaft müssen sich wie alle anderen den veränderten Bedingungen stellen. Vor dem Insolvenzverwalter sind alle gleich. Nicht so vor dem Patienten. In dessen Augen haben die Konfessionellen einen Vorteil: Sie strahlen Nächstenliebe aus. Jetzt gilt es, diesen Wettbewerbsvorteil auszubauen.
Frisches Geld für Kliniken
Authors: Meinke-Carstanjen Annette
Published: March 2016

Unternehmen wollen vermehrt mit Krankenhäusern zusammenarbeiten. Sie übernehmen die Kosten von Gesundheitstrainings, Check-ups und engagieren sich bei Reha-Maßnahmen. Die Firmen erwarten ein hohes Maß an Kundenorientierung. Dem Klinikmarkt eröffnet sich damit eine neue Geldquelle.
Konkurrenz drückt die Kurse
Authors: Schmidt Hartmut
Published: March 2016

Rhön hat gute Zahlen vorgelegt. Dennoch verlor die Aktie fünf Prozent an Wert. Offenbar nahmen viele Anleger die Übernahme von Helios durch Fresenius zum Anlass, ihre Rhön-Aktien zu verkaufen. Ein voreiliger Entschluss: Das Unternehmen dürfte sich der Konkurrenz erwehren – und seinen Weg unbeirrt fortsetzen.
Entlastung in Sicht
Authors: Schmidt Hartmut
Published: March 2016

Ein ganzes Bündel von Kapitalmaßnahmen soll Maternus aus der Verlustzone bringen und die Suche nach einem neuen Großaktionär erleichtern. Die Anleger glauben offenbar an eine fundamentale Besserung: Seit Jahresanfang ist die Aktie um 200 Prozent gestiegen.
Pioniere in Bottrop
Authors: Ghanaat Henrik
Published: March 2016

Die Telekom-Tochter T-Systems und die Bundesknappschaft wollten nicht länger auf die Gesundheitskarte warten. Ende September starteten sie einen Feldtest in Bottrop. Und an dem sollen schon bald 75 Arztpraxen und 20.000 Versicherte teilnehmen.
Daten auf Rädern
Authors: Janning Martina
Published: March 2016

Krankenhaus-Informationssysteme sind aus dem Klinikalltag nicht mehr wegzudenken. Doch noch immer tun sich viele Häuser schwer damit, die digitale Technik überall einzusetzen. Die Kliniken Mönchengladbach haben eine Lösung für mehr Mobilität entwickelt: Ein Visitewagen bringt die elektronische Akte ans Patientenbett.