bluuebunny/crossref_metadata_2025 huggingface dataset:
Previously Incarcerated Transgender Women in Southwestern Pennsylvania: A Mixed Methods Study on Experiences, Needs, and Resiliencies
Authors: Creasy Stephanie L. , Hawk Mary , Friedman Mackey R. , Mair Christina , McNaboe Jennifer , Egan James E.
Published: May 2023

Transgender women are disproportionately incarcerated across the United States, placing a burden of adverse health outcomes on this marginalized population. This exploratory study was designed to document the experiences of transgender women experiencing the cycle of incarceration; explore the degree to which the lack of targeted re-entry services contributes to this cycle of incarceration; and identify structural and/or community-level points for advocacy, support, and programming. We use qualitative interviews and geospatial mapping to describe the lack of access to resources, as well as challenges regarding finding housing, accessing health care, and meeting probation and parole requirements. In 2017, we interviewed six transgender women, all of whom are previously incarcerated adults residing in Allegheny County, Pennsylvania. Additionally, we mapped mental health providers and transinclusive resources using geographic information system software to explore barriers related to transportation and access. Results indicate that access to health care, housing, transportation, and transinclusive community support is the most significant barrier to successful re-entry. These analyses suggest that transgender women residing outside the central downtown area of Pittsburgh have increased difficulty regarding access to probation and parole offices, trans-inclusive health care, and LGBTQIA+ community spaces. These preliminary data suggest that there are missed opportunities within re-entry services to change the social and health trajectories of transgender women who are returning to their communities from jail or prison. Future multilevel interventions should incorporate health care, transinclusive community support, stable housing, and the alleviation of transportation barriers. Colocation of re-entry services may increase access, support, and treatment for transgender women re-entering the community.
Un análisis de los cambios en la nueva inversión 2017 de ISO 17025 y en las directrices de INACAL y su efecto sobre laboratorios acreditados peruanos
Authors: Gutiérrez Lara Ricardo
Published: May 2023

El presente trabajo hace una revisión de los requisitos de la nueva versión de la norma ISO/IEC 17025:2017 General Requirements for the Competence of Testing and Calibration Laboratories, adoptada íntegramente como norma técnica peruana NTP-ISO/IEC 17025:2017 Requisitos generales para la competencia de los laboratorios de ensayo y calibración y los relaciona a las directrices emitidas por el Instituto Nacional de Calidad (INACAL) del Perú, por cuanto algunas de ellas hacen algunos requisitos más exigentes y/o más precisos y claros para su aplicación por los laboratorios acreditados por este entidad. Pretende ser una guía rápida que ayude en la implementación de NTP-ISO/IEC 17025:2017 cumpliendo a la vez con lo requerido por INACAL para los laboratorios que acredita.
El rol de la ética en las finanzas
Authors: Pierre García Jean
Published: May 2023

A la luz del número persistente de escándalos financieros que hacen noticia y que azotan a diversas organizaciones, es razonable preguntarse si acaso existe algo intrínseco a la actividad empresarial o al sistema financiero que promueva el comportamiento poco ético de quienes en ellos participan. Las actividades diseñadas para generar conciencia y prevenir actos indebidos parecen no tener el efecto deseado. ¿Es que actuar moralmente trae como onsecuencia no generar beneficios? En este artículo se reseña la propuesta de un filósofo, Joseph Heath, quien propone que el comportamiento ético ocurre naturalmente cuando aseguramos el correcto funcionamiento del sistema de precios en un mercado competitivo y que, por ello, la moralidad no sería algo externo y extraño sino en realidad intrínseco al desarrollo tanto de las finanzas como de las organizaciones.
Living Off-Grid Food and Infrastructure Collaboration Working Paper 1: Concepts and Assumptions
Authors: Battersby Jane , Brown-Luthango Mercy , Fuseini Issahaka , Gulabani Herry , Haysom Gareth , Jackson Ben , Khandelwal Vrashali , MacGregor Hayley , Mitra Sudeshna , Nisbett Nicholas , Perera Iromi , te Lintelo Dolf , Thorpe Jodie , Toriro Percy
Published: May 2023

This working paper is the product of the Living Off-Grid Food and Infrastructure Collaboration. It is designed to bring together our thinking on how infrastructure can shape the food and nutritional security of urban marginalised populations. Infrastructure assemblages include the material (physical and technological), as well as the political and systemic factors that ‘govern’ how infrastructure is developed and used. Urban food systems are made up of public and private actors, and market and governance processes that shape the cost and availability of food in different urban contexts. At the intersection of urban food systems and infrastructure assemblages lies the food and nutrition security of urban dwellers. The framing of contemporary debates and policy priorities with respect to both nutrition and infrastructure are heavily conditioned by presumptions – in favour of formality and griddedness, for example, or of the need to raise agricultural productivity – which fail to reflect the reality of marginalised communities in Southern cities. For these communities, their experience is one of hybridity, with formal and informal infrastructures and economies central to their lives and livelihoods. These hybrid arrangements are imbued with power structures and socio-political dynamics that are context specific and further condition communities’ experiences. Together, these are the factors that condition or shape the possibilities for individuals and households pursuing different food strategies. However, there is a failure to reflect this reality in the conceptualisation of infrastructure challenges, leading to unworkable solutions and policies that end up perpetuating problems. There is an urgent need to reframe problematic assumptions, starting first and foremost from the entry point of urban informal settlements in the global South. By taking food as a lens in this process, we illuminate these contexts, and how they relate to hybrid infrastructure arrangements and potential alternatives. This reformulation is vital at this critical juncture, when Southern cities need infrastructure development that meets the needs of rapidly changing demographics without locking cities and nations into unsustainable pathways.
PENERAPAN BUDAYA BISNIS GUNA PENINGKATAN CITARASA KOPI PADA KELOMPOK TANI KOPI DI DESA PANDUMAN KECAMATAN JELBUK JEMBER
Authors: Ahsin Kusuma Mawardi Ahmad , Farida Lilik , Nusbandono Ariwan Joko , Prita Septarina , Sofianti Dania
Published: May 2023

Pengembangan kualitas produksi kopi hutan melalui organisasi kelompok tani kopi Arum Sukmo di Dusun Sumbercandik Desa Panduman Kecamatan Jelbuk sebagai Mitra Desa Binaan masih dilakukan secara tradisional. Lemahnya budaya bisnis berdampak pada rendahnya hasil uji citarasa kopi yang dialami Mitra Kelompok Tani Kopi saat ini adalah rendahnya orientasi hasil, rendahnya inovasi dan pengambilan risiko, rendahnya orientasi manusia, rendahnya orientasi tim, dan lemahnya keagresifan. Oleh karena itu, solusi yang ditawarkan pada kegiatan desa binaan ini adalah penguatan budaya bisnis dan kewirausahaan adalah budaya perawatan tanaman, budaya proses bahan baku, budaya petik budaya proses produksi, dan budaya mitra usaha. Jenis luaran dari kegiatan desa binaan dilakukan dengan penguatan budaya bisnis kewirausahaan dengan mengubah perilaku bisnis dan orientasi kewirausahaan yang antara lain: Introduksi SOP perawatan tanaman kopi organik dan pendampingan ke kelompok tani Mitra Desa Binaan; Peningkatan kapasitas produksi kopi organik di Mitra Desa Binaan, paling tidak 2 kali lipat dari kondisi awal; Pengolahan produk pasca panen yang sesuai dengan Standard Pengolahan kopi organik tersertifikasi. Hasil kegiatan yang diusulkan antara lain adalah melakukan uji coba budi daya yang berpedoman pada SOP, demonstrasi dan pelatihan budi daya, dan pengolahan produk pasca panen berdasarkan strandar uji citarasa pengolahan kopi organik
SOSIALISASI UMKM DAN PEMBUATAN LABEL PRODUK SEBAGAI PROGRAM PENGEMBANGAN UMKM LOKAL DESA SUMBERSARI KABUPATEN BONDOWOSO
Authors: Tobing Diana Sulianti K. , Ardhyansyah Gerry
Published: May 2023

UMKM di desa Sumbersari Bondowoso memiliki bermacam-macam jenis dan dapat berpotensi untuk dikembangkan lebih baik lagi. Namun berdasarkan hasil survei yang telah dilakukan bahwa beberapa UMKM masih banyak yang belum memahami dan membangun branding produk mereka. Tujuan dari program kerja kelompok 301 yaitu mengembangkan UMKM lokal supaya dapat lebih baik lagi dari segi kualitas produk sehingga dapat memasarkan produknya lebih luas lagi. Dalam menjalankan program kerja Kelompok 301 telah membagi tugas dengan masing-masing anggota kelompok. Tugas yang dapat dilakukan yaitu menjadi koordinator acara sosialisasi strategi pemasaran dan perizinan usaha, selain itu juga membantu membuat desain label produk untuk 5 UMKM yang kelompok 301 dampingi. Metode yang digunakan adalah diskusi dengan anggota kelompok dan pelaku UMKM.
Elaboração e caracterização de sorvete funcional de hibisco (Hibiscus sabdariffa) com inulina e sem lactose
Authors: Ferrari Gabrieli da Silva , Santos Pedro Paullo Alves dos , Rosa Marciane da Silva , Morato Priscila Neder
Published: May 2023

A pesquisa teve como objetivo o desenvolvimento de sorvete funcional de hibisco sem lactose, com adição de inulina, e avaliou as características físico-químicas, microbiológicas e aceitação sensorial. Foram desenvolvidas duas formulações de sorvete com diferentes concentrações de inulina: Formulação 1 (F1), sorvete de hibisco com adição de 3% de inulina; e a Formulação 2 (F2), sorvete de hibisco com adição de 6% de inulina. As formulações apresentaram os resultados nas análises: umidade (F1: 63,31±4,29%; F2: 66,75±0,35%); lipídeos (F1: 3,74±0,73%; F2: 3,77±0,23%); cinzas (F1: 0,86±0,14%; F2: 0,98±0,27%); proteína (F1: 1,34±0,09%; F2: 1,22±0,23%); fibra bruta (F1: 0,76±0,18%; F2: 0,77±0,08%) – e não diferiram estatisticamente entre si (p ≤0,05). A maioria dos julgadores avaliou as amostras como “gostei moderadamente”. Conclui-se que os sorvetes de hibisco com adição de inulina apresentaram resultados interessantes, que indicam a viabilidade do desenvolvimento do produto que poderá atender dietas específicas e restritas, além de apresentar qualidade nutricional e sensorial.
Consumo alimentar e hábitos de vida de pessoas idosas: hipertensas x normotensas
Authors: Moraes Gabriel Barbosa Delmondes de , Pires Alice Coninck , Pegolo Giovana Eliza
Published: May 2023

Este estudo teve como objetivos descrever características sociodemográficas, hábitos de vida e o consumo de alimentos de pessoas idosas. Trata-se de um estudo transversal. As principais variáveis investigadas foram: consumo de alimentos in natura e ultraprocessados; prática de exercícios físicos/esportes; diagnóstico autorreferido de hipertensão arterial e histórico familiar. Participaram 175 indivíduos (78,9% mulheres). A idade média, para ambos os sexos, foi de 69,7±6,4 anos. Destes, 52,6% se declararam hipertensos e 64,1% desses relataram casos de hipertensão familiar; além disso, 68,5% dos hipertensos relataram diagnóstico de pelo menos outra doença crônica. A frequência da prática de atividades físicas foi maior entre os normotensos. A hipertensão foi associada apenas ao consumo de carne com gordura aparente. As frequências de consumo dos alimentos indicam percentuais de idosos que não consomem diariamente vegetais e frutas. Estratégias de Educação Alimentar e Nutricional e das demais áreas da saúde são essenciais para a promoção da saúde de pessoas idosas.
Automedicação por usuários de uma Estratégia Saúde da Família: uma análise no contexto da pandemia de covid-19
Authors: Souza Maria Carolinne Cardoso de , Conceição Jonatas Reis Bessa da , Goulart Letícia
Published: May 2023

O objetivo foi analisar a prevalência e os fatores associados à automedicação para COVID-19 em usuários de uma Estratégia Saúde da Família (ESF). Trata-se de um estudo observacional e transversal, no qual participaram 124 usuários de ambos os sexos e maiores de 18 anos. Foi aplicado um questionário estruturado na Unidade de Saúde da Família. Um total de 69 (55,64%) participantes informaram consumir medicamentos para covid-19 sem prescrição médica, sendo a maioria sob o intuito de prevenir a doença. Renda familiar de até 1 salário mínimo se relacionou a apresentar 17,46 (OR IC 95% = 2,47-123,251) mais chances de não se automedicar. A prevenção foi o principal norteador para induzir o consumo de medicamentos sem prescrição médica, e a prática se relaciona com maior renda familiar. Faz-se necessário o desenvolvimento de ações de promoção ao uso racional de medicamentos, bem como educação em saúde nos territórios da ESF.
O design e a unidade gráfica da marca do Campeonato Brasileiro de Futebol Masculino
Authors: Ramos Lucas Pereira , Almada Juan Felipe , Barth Mauricio , Pinheiro Cristiano Max Pereira
Published: May 2023

O Campeonato Brasileiro de Futebol Masculino é uma competição anual que envolve as 20 melhores equipes do Brasil e, no ano de 2021, foi transmitido por 5 diferentes plataformas, sendo que cada emissora possuía a sua maneira de ilustrar as informações das partidas por meio de seu pacote gráfico. Nesse sentido, a presente pesquisa tem o objetivo, por intermédio de um levantamento qualitativo, de analisar as respostas de consumidores da competição de futebol mais popular do país, acerca da capacidade de identificação do campeonato por meio de seus elementos gráficos aplicados em transmissões ao vivo, seja pela televisão, seja por plataformas de streaming. Com o resultado obtido, fundamentou-se a necessidade da criação de um manual de identidade visual, trazendo, assim, uma assertividade nas aplicações da marca, em seus elementos de apoio, em qualquer transmissão que envolva o seu conteúdo, fidelizando o consumidor à marca do torneio, criando, assim, uma proximidade entre ela e o torcedor.
Liver Fibrosis in Individuals with Hepatitis C Virus Genotype 1B from Brazilian Eastern Amazon
Authors: Da Silva Tatiane Lobato , Dias Apio Ricardo Nazareth , Quaresma Juarez Antônio Simões , Falcão Luiz Fábio Magno
Published: May 2023

IHepatitis C virus (HCV) has a high genetic diversity, with seven genotypes with 86 subtypes. This genetic variability confers persistence in the infection and escape of the immune system with evolution to cirrhosis and cancer. Environmental factors can contribute to different disease progression, being essential to assess the viral genotype in the infection and discuss the environmental particularities of Eastern Amazon, and the frequencies of Liver fibrosis between different HCV genotypes in patients living in a region of the Brazilian Eastern Brazilian Amazon. Consists in an observational cross-sectional study. Sociodemographic and clinical data of 76 individuals diagnosed with Hepatitis C between 2019 and 2020 in public health services were selected. Data collected was tabulated in Microsoft Excel 2010TM spreadsheets and analysed in GraphPad Prism 5.0TM. Liver fibrosis was associated with genetic subtypes. Subtype 1b was predominant (42.1%), followed by 1a (13%) and 3a (1.3%). 69.7% of participants had chronic hepatitis, with mild fibrosis (F1/F2) being the most prevalent (38.1%). Severe fibrosis was detected in 75% of individuals infected with the subtype 1b, that is associated with more severe disease. We suggest further studies, to assess other communities in the region, as well as the monitoring of these patients with Liver Elastography to determine the disease evolution and its better management.
The Macroscopic Mechanical Equilibrium Condition Governing and Supporting Equilibrium States: the Physical Origin of the Equation of State
Authors: Liu Gang
Published: May 2023

The Macroscopic Mechanical Equilibrium Condition can be shown to be the physical origin of the Equation of State of any material system, then can describe all thermodynamic quasi-equilibrium processes caused by the change of the external temperature and/or mechanical environment. If it cannot be satisfied, the system would be broken.
Zanubrutinib: Coming of Age for BTK Inhibitors in the Treatment of Chronic Lymphocytic Leukemia?
Authors: Molica Stefano , Tam Constantine , Allsup David , Polliack Aaron
Published: May 2023

Ibrutinib, a first-in-class Bruton’s Tyrosine Kinase inhibitor (BTKi), is a commonly deployed therapeutic option for previously untreated, and relapsed/refractory (R/R) patients with chronic lymphocytic leukemia (CLL). The use of ibrutinib is, however, partially limited by significant off-target side effects. Zanubrutinib (zanu) is a second-generation BTKi with enhanced target selectivity and occupancy of the kinase binding site. The SEQUOIA study showed that zanu significantly prolonged progression-free survival (PFS) when compared to bendamustine–rituximab (BR) in treatment-naive CLL patients with an acceptable safety profile. More recently, data from the phase III ALPINE trial which directly compared zanu with ibrutinib has demonstrated that zanu’s advantages are both an improved safety profile and enhanced clinical efficacy.
Based on the results of the SEQUOIA and ALPINE pivotal trials the Food and Drug Administration (FDA) and European Medicines Agency (EMA) licensed zanu for the treatment of patients with CLL or small lymphocytic lymphoma (SLL) in January 2023. The updated (v2.2023) National Comprehensive Cancer Network (NCCN) guidelines and newly released German CLL algorithm, suggest that zanu may replace first-generation BTKi as one of the preferred therapeutic options for patients with CLL/SLL due to its increased selectivity for the kinase binding site, improved therapeutic efficacy, and favorable toxicity profile.
CD10-Bound Human Mesenchymal Stem/Stromal Cell-Derived Exosomes Possess Immunomodulatory Cargo and Maintain Cartilage Homeostasis under Inflammatory Conditions
Authors: Kouroupis Dimitrios , Kaplan Lee D. , Huard Johnny , Best Thomas M.
Published: May 2023

The onset and progression of human inflammatory joint diseases are strongly controlled by the activation of resident synovium/infrapatellar fat pad (IFP) pro-inflammatory and pain-transmitting signaling. We recently reported that intra-articularly injected IFP-derived Mesenchymal Stem/Stromal Cells (IFP-MSC) acquire a potent immunomodulatory phenotype and actively degrade Substance P (SP) via neutral endopeptidase CD10 (neprilysin). Our hypothesis is that IFP-MSC robust immunomodulatory therapeutic ef-fects are largely exerted via their CD10-bound exosomal secretome (IFP-MSC EXOs) by attenuating synoviocyte pro-inflammatory activation and articular cartilage degradation. Herein, IFP-MSC EXOs were isolated from CD10High- and CD10Low-expressing IFP-MSC cultures and their exosomal miRNA cargo was assessed using multiplex methods. Functionally, we interrogated the effect of CD10High and CD10Low EXOs on stimulated by inflammatory/fibrotic cues synoviocytes monocultures and cocultures with IFP-MSC de-rived chondropellets. Finally, CD10High EXOs were tested in vivo for their therapeutic capacity in an animal model of acute synovitis/fat pad fibrosis. Our results showed that CD10High and CD10Low EXOs possess distinct miRNA profiles. Reactome analysis of miRNAs highly present in exosomes showed their involvement in the regulation of six gene groups, particularly the immune system. Stimulated synoviocytes exposed to IFP-MSC EXOs demonstrated significantly reduced proliferation and altered inflammation-related molecular profiles compared to control stimulated synoviocytes. Importantly, CD10High EXOs treatment of stimulated chondropellets/synoviocytes cocultures indicated a significant chondroprotective effects. Therapeutically, CD10High EXOs treatment resulted in robust chondroprotective effects by retaining articular cartilage structure/composition and PRG4 (lubricin)-expressing cartilage cells in the animal model of acute synovitis/IFP fibrosis. Our study suggests that CD10High EXOs possess immuno-modulatory miRNA attributes with strong chondroprotective/anabolic effects for articular cartilage in vivo. The results could serve as a foundation for EXOs-based therapeutics for the resolution of detrimental aspects of immune-mediated inflammatory joint changes associated with conditions such as osteoarthritis (OA).
The Growth Oscillator and Plant Stomata: an Open and Shut Case
Authors: Lamport Derek T
Published: May 2023

Since Darwin’s “Power of movement in plants” the precise mechanism of oscillatory plant growth remains elusive. Hence the search continues for the hypothetical growth oscillator that regulates a huge range of growth phenomena ranging from circumnutation to pollen tube tip growth and stomatal movements. Oscillators are essentially simple devices with few components. A universal growth oscillator with only four major components became apparent recently with the discovery of a missing component, notably arabinogalactan glycoproteins (AGPs) that store dynamic Ca2+ at the cell surface. Demonstrably, auxin-activated proton pumps, AGPs, Ca2+ channels and auxin efflux “PIN” proteins, embedded in the plasma membrane, combine to generate cytosolic Ca2+ oscillations that ultimately regulate oscillatory growth: Hechtian adhesion of the plasma membrane to the cell wall and auxin-activated proton pumps trigger the release of dynamic Ca2+ stored in periplasmic AGP monolayers. These four major components represent a molecular PINball machine a strong visual metaphor that also recognizes auxin efflux “PIN” proteins as an essential component. Proton “pinballs” dissociate Ca2+ ions bound by paired glucuronic acid residues of AGP glycomodules, hence reassesses the role of proton pumps. It shifts the prevalent paradigm away from the recalcitrant “acid growth” theory that proposes direct action on cell wall properties, with an alternative explanation that connects proton pumps to Ca2+ signaling with dynamic Ca2+ storage by AGPs, auxin transport by auxin-efflux PIN proteins and Ca2+ channels. The extensive Ca2+ signalling literature of plants ignores arabinogalactan proteins (AGPs). Such scepticism leads us to reconsider the validity of the universal growth oscillator proposed here with some exceptions that involve marine plants and perhaps the most complex stress-test, stomatal regulation.
Comparative Proteomic Analysis of Toxoplasma gondii Rh Wild-type and Four SRS29B (SAG1) Knock-Out Clones Reveals Significant Differences Between Individual Strains
Authors: Hänggeli Kai Pascal Alexander , Hemphill Andrew , Müller Norbert , Heller Manfred , Anne-Christine Uldry , Braga-Lagache Sophie , Müller Joachim , Boubaker Ghalia
Published: May 2023

In T. gondii, as well as in other model organisms, gene knock-out using CRISPR-Cas9 is a suitable tool to identify the role of specific genes. The general consensus implies that only the gene of interest is affected by the knock-out. Is this really the case? In a previous study, we have generated knock-out (KO) clones of TgRH88_077450 (SRS29B; SAG1) which differed in the numbers of integrated dihydrofolate-reductase-thymidylate-synthase (MDHFR-TS) drug-selectable marker. Clones 18 and 33 had a single insertion of MDHFR-TS within SRS29B. Clone 6 was disrupted by the insertion of a short unrelated DNA-sequence, but the marker was integrated elsewhere. In clone 30, the marker was inserted into SRS29B and several other MDHFR-TS copies were found in the genome. KO and wild-type (WT) tachyzoites had similar shape, dimensions and vitality. This prompted us to investigate the impact of the genetic engineering as such on the overall proteome patterns of the four clones as compared to the respective WT. Comparative shotgun proteomics of the five strains was performed. Overall, 3236 proteins were identified. Principal component analysis of the proteomes revealed five distinct clusters corresponding to the five strains by both iTop3 and iLFQ algorithms. Detailed analysis of the differentially expressed proteins revealed that the target of the KO, srs29B, was lacking in all KO clones. Besides this protein, twenty other proteins were differentially expressed between KO clones and WT or between different KO clones. The protein exhibiting the highest variation between the five strains was srs36D encoded by TgRH_016110. The deregulated expression of SRS36D was further validated by quantitative PCR. Moreover, the transcript levels of three other selected SRS genes, namely SRS36B, SRS46, and SRS57 exhibited significant differences between individual strains. These results indicate that knocking out a given gene may affect the expression of other genes. Therefore, care must be taken when specific phenotypes are regarded as a direct consequence of the KO of a given gene.
PHYSICAL AND CHEMICAL PROPERTIES OF SILVER-CONTAINING NANOSORBENT OBTAINED FROM RICE STRAW BIOCHAR
Authors: Smolyanichenko Alla
Published: May 2023

Improving the quality of natural water purification is one of the priority areas in the research of scientific communities in the field of ecology. At the same time, the task is to achieve optimal efficiency at a low cost of the technological process. The solution in this case is the use of materials necessary for cleaning, in particular, sorbents from natural raw materials, including agricultural waste. At present, a sufficient number of research results have been published confirming the effectiveness of the sorbent from biochar of various agricultural wastes, as well as from rice straw biochar. This article proposes an innovative method for modifying biochar from rice straw, which allows the use of the material as a sorbent with a disinfecting effect. The method consists in processing biochar in a process activation apparatus (PAP) in a solution of silver nitrate with the release in the form of a carbon nanomaterial with attached metallic silver ions on the surface of biochar particles. Rice straw biochar was mixed in distilled water with silver nitrate AgNO3 and placed in the AAP in a replaceable insert with ferromagnetic particles that have a magnetostrictive effect under the influence of an electromagnetic field. Next, the contact of biochar impregnated with a solution of silver nitrate and ferromagnetic particles was carried out for 2 minutes under electromagnetic influence, after which the treated sample was dried in an oven for 4 hours at t=105ºС, followed by calcination in a muffle furnace at 450ºС for 3 hours. The resulting silver-containing sorbent was subjected to a physicochemical analysis of its properties, photographs of electron microscopy were also obtained, and a bacteriological analysis of the effectiveness of the sorbent on natural water was carried out. According to the results of the analyzes, the silver-containing sorbent is a mesoporous nanomaterial with an average mesopore diameter for desorption of 196 Å, a relative volume of pores with a diameter of up to 900 Å 0.034 cm3/g,, specific surface 7.45 m2/g and a content of metallic silver ions on the surface of the sorbent particles of (Ag) 16.7%, oxygen (O) 54.9%, unexpectedly (С) 13.7%, silicon (Si) 8.1%. Laboratory studies for the bacteriological analysis of natural water consisted in the sorption processing of the selected samples in the carbonization mode, followed by sedimentation after the introduction of the reagent (a mixture of coagulant and flocculant). The analysis was carried out on three indicators - total microbial count (TMC), total coliform bacteria (TCB) and thermotolerant coliform bacteria (TCB). According to the research results, the sorbent showed its disinfecting properties and confirmed its high efficiency (90,48%-100%).
Exploring the Performance Boundaries of a Reconfigurable Multi-Mission Military UAV through Multidisciplinary Analysis
Authors: Santos Dioser , Rogers Jeremy , De Rezende Armando , Maldonado Victor
Published: May 2023

The performance of a small reconfigurable unmanned aerial vehicle (UAV) is evaluated, 1 combining a multidisciplinary approach in computational analysis of additive manufactured struc- 2 tures, fluid dynamics, and experiments. Reconfigurable UAVs promise cost savings and efficiency 3 without sacrificing performance, while demonstrating versatility to fulfill different military mission 4 profiles. The use of computational fluid dynamics (CFD) in UAV design produces higher accuracy 5 aerodynamic data, which is particularly important for complex aircraft concepts such as blended 6 wing bodies. To address challenges relating to anisotropic materials, the Tsai-Wu failure criterion is 7 applied to structural analysis, using CFD solutions as load inputs. Aerodynamic performance results 8 show the low-speed variant attains an endurance of 1 hour, 48 minutes, whereas for its high-speed 9 counterpart, it is 29 minutes at 66.7% higher cruise speed. Each variant serves different aspects of 10 small UAS deployment in combat, with low-speed envisioned for close surveillance, and high-speed 11 for incursions. Experimental and simulation results suggest room for design iteration, in wing area 12 and geometry adjustments. Structural simulations demonstrated the need for airframe improvements 13 in the low-speed configuration. This paper highlights the potential of reconfigurable UAVs to disrupt 14 the industry, advocating for further research and design improvements.
Improving Bug Assignment and Developer Allocation in Soft-ware Engineering through Interpretable Machine Learning Models
Authors: Shenouda Mina Samir , Sherief Nada H. , Abdelmoez Walid M.
Published: May 2023

Software engineering is a comprehensive process that requires developers and team members to collaborate across multiple tasks. In software testing, bug triaging is a tedious and time-consuming process. Assigning bugs to the appropriate developers can save time and maintain their motivation. However, without knowledge about a bug's class, triaging is difficult. Motivated by this challenge, this paper focuses on the problem of assigning the suitable developer to new bug by analyzing the history of developers’ profiles and analyzing history of bugs for all developers using machine learning-based recommender systems. Explainable AI (XAI) is AI that humans can understand. It contrasts with "black box" AI, which even its designers can't explain. By providing appropriate explanations for results, users can better comprehend the underlying insight behind the outcomes, boosting the recommender system's effectiveness, transparency, and confidence. In this paper, we propose two explainable models for recommendation. The first one is an explainable recommender model for personalized developers generated from bug history to know what the preferred type of bug is for each developer. The second model is an explainable recommender model based on bugs to generate the best developer for each bug from bug history.
Enhancing Industrial Cyber Security, Focusing on Formulating a Practical Strategy for Making Predictions Through Machine Learning Tools in Cloud Computing Environment
Authors: Abbas Zaheer , Myeong Seunghwan
Published: May 2023

Cloud computing has revolutionized how industries store, process, and access data. However, the increasing adoption of cloud technology has also raised concerns regarding data security. Machine learning (ML) is a promising technique to enhance cloud computing security. This paper focuses on utilizing ML techniques (Support Vector Machine, XGBoost, and Artificial Neural Networks) to progress cloud computing security in the industry. The selection of 11 important features for the ML study satisfies the study's objectives. This study focused on identifying gaps in utilizing ML techniques in cloud cyber security. Moreover. this study aims at developing a practical strategy for predicting the employment of machine learning in an Industrial Cloud environment regarding trust and privacy issues. The efficiency of the employed models is assessed by applying validation matrices of Precision, Accuracy, Recall values, F1 score, R.O.C. curves, and Confusion matrix. The results demonstrated that the X.G.B. model outperformed in terms of all the matrices with an Accuracy of 97.50 %, 97.60 % Precision, 97.60 % Recall values, and 97.50 % F1 score. This research highlights the potential of ML algorithms in enhancing cloud computing security for industries. It emphasizes the need for continued research and development to create more advanced and efficient security solutions for cloud computing.
Nipping at the Bud Stage: Controlling Future Diabetes Burden by Preventive Oral Health Care Approach for Early Childhood Dental Caries
Authors: Gallaba Sachee , Perera Irosha , Gunasekara Uthpala , Gamlathge Pushpa
Published: May 2023

Diabetes mellitus and dental caries (tooth decay) are not only common Non Communicable Diseases (NCDs) contributing to high burden of diseases but costly diseases to manage. Diabetes mellitus is a leading cause of mortality and reduced life expectancy across the globe. Early child hood dental caries (ECC) denotes a common chronic childhood disease and cariogenic dietary patterns dominated by refined sugar is one of the main causative factors. Thus, high burden of ECC could be a proxy indicator of excessive refined sugar consumption of a child. If such unhealthy dietary patterns are continued through to adolescent to adulthood, there is a high probability of an individual becoming a diabetic. Therefore, it is rational to argue high ECC burden in a country could be an indicator of future burden of diabetes. Moreover, ECC provides a critical period and a window of opportunity across life-course perspective, to intervene with cariogenic dietary patterns underpinned by common risk factor approach. This could be achieved by tailored dietary counseling for parental care givers of children with ECC. A healthy dietary pattern fostered in the childhood, most probably would continue to adulthood which may become beneficial in reducing the incidence of diabetes. Against this backdrop, we provide a perspective from Sri Lanka: a lower-middle-income country (LMIC) which records the highest prevalence of diabetes and pre-diabetes in south Asia. Our perspective will provide novel insights and innovative ideas into prevention and control of diabetes burden in LMICs, harnessing the potential of preventive dentistry.
Chitosan-Based Biomaterials for Hemostatic Applications: A Review on Recent Advances
Authors: Gheorghita Daniela , Moldovan Horatiu , Robu Alina , Bita Ana-Iulia , Grosu Elena , Antoniac Aurora , Corneschi Iuliana , Antoniac Iulian , Bodog Alin Danut , Bacila Ciprian Ionut
Published: May 2023

Hemorrhage is a detrimental event present in traumatic injury, surgery, and disorders of bleeding, that can become life-threatening if not properly managed. Moreover, uncontrolled bleeding can complicate surgical interventions, altering the outcome of surgical procedures. Therefore, to reduce the risk of complications and decrease the risk of morbidity and mortality associated with hemorrhage, it is necessary to use an effective hemostatic agent that ensures immediate control of bleeding. In recent years, there have been increasingly rapid advances in developing novel generation of biomaterials with hemostatic properties. Nowadays, a wide array of topical hemostatic agents is available, including chitosan-based biomaterials that have shown outstanding properties such as: antibacterial, antifungal, hemostatic, analgesic activity, in addition to their biocompatibility, biodegradability, and wound-healing effects. This review provides an analysis of chitosan-based hemostatic and discusses the progress made in their performance, mechanism of action, efficacy, cost, and safety in recent years.
Thiourea Derivatives Rejuvenate Mitochondria and Provide Anti-viral Activity Against Chronic Hepatitis B Infection
Authors: Kumar Jitendra , Tyagi Purnima , Saini Akhilesh Kumar , Sharma Deepti , Maras Jaswinder Singh , Kumar Vijay
Published: May 2023

Chronic hepatitis B (CHB) infection and the Hepatitis B virus protein X (HBx) are a major risk factor for the development of hepatocellular carcinoma (HCC). In CHB, HBx induces mitochondrial dysfunction, exhaustion and impaired function in hepatocytes. Restoring hepatocyte health along with reduction in virus replication could be an ideal treatment of CHB. Thiourea derivatives are well known for their antiviral property though their effect on mitochondrial and/ or hepatocyte health is obscure. The current pilot study focus on the repurposing of DSA-00, DSA-02, and DSA-09 on mitochondrial health and hepatocyte replenishment. HepG2.2.15 cells were treated with these, alongside Entecavir (ETV). The proteomics analysis showed DSA-00 and ETV were enriched with proteins associated with antiviral responses. DSA-00 additionally showed increase in proteins linked to mitochondrial response. DSA-02 showed association with innate immune system and citric acid cycle. DSA-09 displayed pathways similar to DSA-00 and ETV. The treated groups exhibited enhanced bio-energetic and antiviral response compared to the untreated group. FACS analysis, validated thiourea derivatives restored exhausted hepatocytes by targeting mitochondrial potential and function. Our findings suggest that (DSA-00, DSA-02, and DSA-09) may hold potential as a novel treatment strategy restoring mitochondrial healthy along with anti-viral response in CHB.
Comparative Analysis of Maternal and Neonatal Outcomes between Elective and Emergency Cesarean Section at a Single Tertiary Hospital
Authors: Al Riyami Nihal , Al Shereiqi Shurooq , Pillai Silja
Published: May 2023

The aim of this study was to determine the most common maternal and neonatal complications related to cesarean section at Sultan Qaboos University Hospital (SQUH) and to compare the outcomes between emergency and elective cesarean sections. A retrospective cohort study was conducted in the department of Obstetrics and Gynecology at SQUH from 1st January 2016 to 31st December 2016. This comparative study involved 300 women who underwent cesarean section, 150 in elective cesarean section group and 150 in emergency cesarean section group. Data was collected from the delivery ward maternity registry and Electronic Patient Records. SPSS software version 23 was used to analyze the data.The mean maternal age was 29.66 (± 4.96) and 33.22 (± 4.63) years in the elective and emergency cesarean section groups respectively (p=001). The main risk factor for both the groups was maternal diabetes and the most common indication for both was previous cesarean section. Hypotension related anesthetic complication was noted more in elective cesarean section (15.3%) than in emergency cesarean section group (4.0%) with p value=0.002. The most common major intraoperative complication in both groups was postpartum hemorrhage, 66.9% women in emergency group and 63.0% women in elective group. Post-partum fever was seen in 12.0% of women in emergency group as compared to 4% in elective group (p=0.019). Anemia was observed in 79.2% and 65.3% in emergency and elective groups respectively (p=0.011). Respiratory distress syndrome and transient tachypnea of the newborn were the main neonatal complications in both groups. There was no significant difference between emergency and elective cesarean section related maternal and neonatal complications except for transient intraoperative hypotension, maternal postoperative febrile morbidity and anemia. Future prospective studies including larger sample size and multiple centers is recommended.
Phylogeny and Taxonomy of the Genus Amphichorda (Bionectriaceae): An Update on Beauveria-like Strains and Description of a Novel Species from Marine Sediments
Authors: Guerra-Mateo Daniel , Gené Josepa , Baulin Vladimir , Cano-Lira José F.
Published: May 2023

The genus Amphichorda has been recently re-erected as an independent linage from Beauveria, circumscribed within Cordycipitaceae. However, its phylogenetic relationships with other members of this family remain obscure. In our on-going efforts to expand the knowledge on the diversity of culturable ascomycetes from the Mediterranean Sea, we isolated several specimens of Amphichorda. Preliminary sequence analyses revealed great phylogenetic distance with accepted Amphichorda species and a close relation to Onychophora coprophila. Onychophora is a monotypic genus of enteroblastic conidiogenous cells, presumably related to Acremonium (Bionectriaceae); while Amphichorda exhibits holoblastic conidiogenesis. Here, we examine representative strains of Amphichorda species to resolve the taxonomy of the genus and the above-mentioned fungi combining morphological, ultrastructure and multi-locus phylogenetic analyses (ITS, LSU, tef1, BenA). The results revealed Amphichorda as a member of the Bionectriaceae, where its asexual morphs represent a transition between enteroblastic and holoblastic conidiogenesis for this group of fungi. We also describe and illustrate Amphichorda littoralis sp. nov., and propose the new combination Amphichorda coprophila. In addition, we stablish key phenotypic features to distinguish Amphichorda species and demonstrate the higher salt tolerance degree of A. littoralis, consistent with its marine origin. This work provides a comprehensive framework for future studies in the genus.
Associations of Clinical and Dosimetric Parameters with Urinary Toxicities after Prostate Brachytherapy: A Long-Term Single-Institution Experience
Authors: Ito Masaya , Makita Chiyoko , Mori Takayuki , Takano Hirota , Kumano Tomoyasu , Matsuo Masayuki , Iinuma Koji , Kawase Makoto , Nakane Keita , Nakano Masahiro , Kumano Tomoyasu
Published: May 2023

To examine the association of clinical, treatment, and dose parameters with late urinary toxicity after low-dose-rate brachytherapy (LDR-BT) for prostate cancer, we retrospectively studied patients with prostate cancer who underwent LDR-BT from January 2007 through December 2016. Urinary toxicity was assessed using the International Prostate Symptom Score (IPSS) and Overactive Bladder (OAB) Symptom Score (OABSS). Severe and moderate lower urinary tract symptoms (LUTS) were defined as IPSS ≥ 20 and ≥ 8, respectively; OAB was defined as a nocturnal frequency of ≥ 2 and a total OABSS of ≥ 3. In total, 203 patients (median age, 66 years) were included, with a mean follow-up of 8.4 years after treatment. The IPSS and OABSS worsened after 3 months of treatment; these scores improved to pretreatment levels after 18–36 months in most patients. Patients with a higher baseline IPSS and OABSS had a lower frequency of moderate and severe LUTS and OAB at 24 and 60 months, respectively. LUTS and OAB at 24 and 60 months were not correlated with the dosimetric factors of LDR-BT. Although the rate of long-term urinary toxicities assessed using IPSS and OABSS was low, the baseline scores were related to long-term function. Refining patient selection may further reduce long-term urinary toxicity.
A Review of State-of-the-art and Short-Term Forecasting Models for Solar PV Power Generation
Authors: Tsai Wen-Chang , Tu Chia-Sheng , Hong Chih-Ming , Lin Whei-Min
Published: May 2023

Accurately predicting the power of solar power generation can greatly reduce the impact of the randomness and volatility of power generation on the stability of the power grid system, which is beneficial for the balanced operation and optimized dispatch of the power grid system, and reduces operating costs. Solar PV power generation depends on weather conditions, which are prone to large fluctuations under different weather conditions. Its power generation is characterized by randomness, volatility and intermittency. Recently, the demand for further investigation and effective use on the uncertainty of short-term solar PV power generation prediction has been getting increasing attention in many application of renewable energy sources. In order to improve the predictive accuracy of output power of solar PV power generation and develop a precise predictive model, the authors worked predictive algorithms for the output power of a solar PV power generation system. Moreover, since short-term solar PV power forecasting is one of the important aspects for optimizing the operation and control of renewable energy systems and electricity markets, this review focuses on the predictive models of solar PV power generation, which can be verified in the daily planning and operation of a smart grid system. In addition, the predictive methods in the reviewed literature are classified according to the input data source used for accurate predictive models, and the case studies and examples proposed are analyzed in detail. The contributions, advantages and disadvantages of the predictive probabilistic methods are compared. Finally, the future studies of short-term solar PV power forecasting is proposed.
Határokról határon innen és túlról – Beszámoló a 21. Élőnyelvi Konferenciáról
Authors: Jánk István , Sinkovics Balázs
Published: May 2023

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Az áru- és márkanevek tárgyalásának jellegzetességei az anyanyelvi taneszközökben
Authors: Takács Judit
Published: May 2023

A tanulmány azt vizsgálja, milyen terjedelemben és feladattípusok által jelennek meg az áru- és a márkanevekhez kapcsolódó ismeretek az általános iskola 3., 4. és 6. évfolyamának taneszközeiben. Célja elsősorban annak feltárása, hogy a névtani ismeretek átadása során a többihez képest mekkora súly esik e marginális helyzetű, a magyar névtanban ritkán kutatott névfajta megismertetésére. Emellett vizsgálja azt is, hogy az adott névtípust jellemzően milyen feladattípusok és tipikus névegyedek által mutatják be a tankönyvírók. A többi névtípushoz hasonlóan a márkanevekkel kapcsolatban is dominánsan tulajdonnevekre vonatkozó feladatokat találunk. Az onomasztikai feladatok is leginkább csak az egyes termékkategóriák jellemző neveit adják meg. Azok, amelyek például a „jó márkanév” kialakításának módjára, az egyes kategóriák közti (például személynév → márkanév vagy márkanév → fajtanév) változásra vonatkoznának, illetve ezek esetleges helyesírási kérdéseit tárnák fel, a vizsgált taneszközökben szórványosan jelennek csak meg.
Az anyanyelvi órák zárása retorikai és szakpedagógiai nézőpontból
Authors: Antalné Szabó Ágnes
Published: May 2023

Az óratervezés olyan komplex folyamat, amelyben több tudományterület kutatási eredményeire is lehet, sőt szükséges építeni. A tanulmány azt vizsgálja, hogyan alkalmazhatók a retorika tanításai az anyanyelvi órák záró szakaszának a megtervezésében. A retorikai nézőponton túl didaktikai, szakpedagógiai szempontból is foglalkozik az RJR-modellre épülő anyanyelvi órák reflektáló szakaszának a céljaival és funkcióival, továbbá pszichológiai kutatási eredményekkel is alátámasztja a retorikai elvek alkalmazásának a hasznosságát és szükségességét. A tanulmány bemutatja az anyanyelvi órák tervezésével kapcsolatos, két nem reprezentatív vizsgálat eredményeit. Ezeknek célja annak feltárása volt, hogy a magyartanárjelölt hallgatók mennyire veszik figyelembe a korábban megismert anyanyelv-pedagógiai ajánlásokat az óratervezéskor az anyanyelv-pedagógiai szemináriumon, valamint az összefüggő egyéni iskolai gyakorlaton, tartalmaz-e az óratervük összegző, reflektáló részt, valamint ehhez milyen módszertani megoldást választanak. A tanulmány befejező része példákat mutat be az anyanyelvi órák záró szakaszában alkalmazható gyakorlattípusokra, figyelembe véve a retorikai és a szakpedagógiai elveket egyaránt.
Goda Beatrix – Péterfi Rita (szerk.): Szöveg nélküli képkönyvek. Elmélet és gyakorlat (Szabó Ildikó)
Authors: Szabó Ildikó
Published: May 2023

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