bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of fermented sea buckthorn (Hippophae rhamnoides L.) juice and investigation of its antioxidant and antimicrobial activity
Authors: Liu Xiaolu , Lv Mingshan , Maimaitiyiming Ruxianguli , Chen Keping , Tuerhong Nuersiman , Yang Jiangyong , Aihaiti Aihemaitijiang , Wang Liang
Published: January 2023

Sea buckthorn (Hippophae rhamnoides L.) is an edible and medicinal plant species. However, due to its sour taste, it is not readily accepted by consumers. To overcome this, fermentation can be used to change its flavor profile. In this study, we used response surface methodology (RSM) to determine the best process for producing fermented sea buckthorn juice (FSBJ) using probiotics. The biological enzyme activity and total flavonoid content (TFC) of sea buckthorn juice (SBJ) increased after fermentation. When the number of bacteria inoculated was 4.08 × 106 CFU/mL and the inoculation ratio was 30% Z. mobilis, 5% L. casei, 13.75% L. plantarum, 31.25% P. acidilactici, 12.5% L. animalis, and 7.5% P. pentosaceus, the amount of sugar was 2.98% (w/v) after 20 h of fermentation at 37°C, and the superoxide dismutase (SOD) activity reached 725.44 U/mL, and the TFC reached 2.38 mg/mL. FSBJ demonstrated strong antimicrobial activity against Escherichia coli, Staphylococcus aureus and Botrytis cinerea. Then, to investigate the antioxidant capacity of FSBJ, we used H2O2 to induce oxidative stress in C2C12 cells and assessed the protection conferred by FSBJ to damaged cells. It was discovered that after 24 h of treatment with FSBJ, not only was there an increase in the activities of intracellular SOD and glutathione peroxidase (GSH-Px), but also a reduction in reactive oxygen species (ROS) content, catalase (CAT) activity, and malondialdehyde (MDA) content. This research lays the theoretical groundwork and provides reference materials for the improved fermentation of sea buckthorn and demonstrates its resulting antioxidant effect.
Two levels vs. one level of phallopexy in the treatment of concealed penis in patients in pediatric age group
Authors: Elrouby Ahmed , Saad Israa , Kotb Mostafa
Published: January 2023

Introduction

Concealed penis, which is the congenital type of buried penis, is a condition in which a normal-sized penis is totally or partially hidden by pubic, scrotal, or thigh skin. Several procedures had been described for its correction including phallopexy, that is, fixation of penile Buck's fascia to the sub-dermis.

Aim of the work

Our work aims to study the difference in outcome between performing phallopexy at one level and at two levels.

Material and methods

Our study included 180 uncircumcised patients who had a concealed penis while having an average length of an outstretched penis. These patients were divided into two groups: the first one was treated with one level of phallopexy at the 3 and 9 o'clock points, while the second group was treated with the same procedure in addition to another level of stitches at the mid-penile level. The follow-up was carried out for one post-operative year regarding penile skin edema, infection, congestion, necrosis, and/or re-retraction.

Results

The overall success rate was 96.1% for a normally-looking penis without post-operative re-retraction. Re-retraction developed in two patients (2.2%) of those who had one-level phallopexy and in five patients (5.6%) of those who had two-level phallopexy without statistical significance (FEp = .444). Penile skin edema developed in 76 patients (42.2%) being significantly lower in patients with lower body weight (p = .030*).

Conclusion

Phallopexy could be performed safely in the case of the concealed penis with satisfactory results. Two levels of phallopexy did not add any advantage to the post-operative results besides the fact that this may be demanding, time-consuming, and may require higher resources, so we recommend the easier one-level phallopexy in the treatment of such conditions with satisfactory results.
Radial head and neck fractures in children and adolescents
Authors: Kalbitz Miriam , Lackner Ina , Perl Mario , Pressmar Jochen
Published: January 2023

Background

Radial head and neck fractures are a rare entity in pediatric patients. Due to specific characteristics of the blood supply and remodeling potential, the correct diagnosis and initiation of appropriate therapy are crucial for the outcome. Therefore, the aim of this retrospective observational study was to present the outcome of a series of pediatric patients with radial head and neck fractures.

Methods

In total, 67 pediatric and adolescent patients with a fracture of the proximal radius admitted to a Level I Trauma Center (Germany) between 2005 and 2017 were included in this retrospective observational study. Patients were stratified in accordance with the classification of Judet modified by Metaizeau and with the AO Pediatric Comprehensive Classification of Long Bone Fractures (AO-PCCF).

Results

AO-PCCF fracture type of proximal radius was age-dependent. Epiphyseal axis angle and displacement angle correlated significantly. Fractures treated with a K-wire or embrochage centromedullaire elastique stable (ECMES) presented higher displacement angles. The duration of callus formation was dependent on both the reduction technique and fracture displacement. The range of motion after complete fracture consolidation was dependent on the Metaizeau type and reduction technique but independent of the duration of immobilization and physical therapy.

Conclusion and clinical relevance

Both the epiphyseal axis and displacement angle are suitable for measuring the initial fracture displacement in radiographs. Consolidation is dependent on the initial displacement and reduction technique. The mini-open approach leads to a worse reduction result, later callus formation, and a more restricted range of motion in terms of pronation. Furthermore, the range of motion at follow-up is independent of the duration of immobilization and physiotherapy.
Nephron-sparing surgery for Wilms tumor
Authors: Murphy Andrew J. , Davidoff Andrew M.
Published: January 2023

The algorithm that has been used successfully in the surgical management of unilateral Wilms tumor, radical nephroureterectomy, cannot be used in children who present with synchronous bilateral renal masses. Instead, a surgical approach that removes all tumor masses while preserving as much normal renal parenchyma as possible is encouraged to avoid acute and long-term renal insufficiency. We will review technical aspects of the conduct of nephron-sparing surgery for synchronous bilateral Wilms tumor, including the more recent advances in the use of imaging adjuncts such as pre-operative 3D imaging and fluorescence-guided surgery. The potential role of nephron-sparing surgery for unilateral Wilms tumor will also be discussed.
Nanomolar clodronate induces adenosine accumulation in the perfused rat mesenteric bed and mesentery-derived endothelial cells
Authors: Donoso M. Verónica , Hernández Felipe , Barra Rafael , Huidobro-Toro J. Pablo
Published: January 2023

The vesicular nucleotide transporter (VNUT) is critical for sympathetic co-transmission and purinergic transmission maintenance. To examine this proposal, we assessed whether the bisphosphonate clodronate, claimed as a potent in vitro VNUT blocker, modified spontaneous and/or the electrically evoked overflow of ATP/metabolites and NA from mesentery sympathetic perivascular nerve terminals. Additionally, in primary endothelial cell cultures derived from this tissue, we also evaluated whether clodronate interfered with ATP/metabolite cell outflow and metabolism of N6-etheno adenosine 5′-triphosphate (eATP), N6-etheno adenosine (eADO), and adenosine deaminase enzyme activity. Rat mesenteries were perfused in the absence or presence of .01–1,000 nM clodronate, 1–1,000 nM Evans blue (EB), and 1–10 µM DIDS; tissue perfusates were collected to determine ATP/metabolites and NA before, during, and after perivascular electrical nerve terminal depolarization. An amount of 1–1,000 nM clodronate did not modify the time course of ATP or NA overflow elicited by nerve terminal depolarization, and only 10 nM clodronate significantly augmented perfusate adenosine. Electrical nerve terminal stimulation increased tissue perfusion pressure that was significantly reduced only by 10 nM clodronate [90.0 ± 18.6 (n = 8) to 35.0 ± 10.4 (n = 7), p = .0277]. As controls, EB, DIDS, or reserpine treatment reduced the overflow of ATP/metabolites and NA in a concentration-dependent manner elicited by nerve terminal depolarization. Moreover, mechanical stimulation of primary endothelial cell cultures from the rat mesentery added with 10 or 100 nM clodronate increased adenosine in the cell media. eATP was metabolized by endothelial cells to the same extent with and without 1–1,000 nM clodronate, suggesting the bisphosphonate did not interfere with nucleotide ectoenzyme metabolism. In contrast, extracellular eADO remained intact, indicating that this nucleoside is neither metabolized nor transported intracellularly. Furthermore, only 10 nM clodronate inhibited (15.5%) adenosine metabolism to inosine in endothelial cells as well as in a commercial crude adenosine deaminase enzyme preparation (12.7%), and both effects proved the significance (p < .05). Altogether, present data allow inferring that clodronate inhibits adenosine deaminase activity in isolated endothelial cells as in a crude extract preparation, a finding that may account for adenosine accumulation following clodronate mesentery perfusion.
Wavelet analysis of laser Doppler microcirculatory signals: Current applications and limitations
Authors: Kralj Lana , Lenasi Helena
Published: January 2023

Laser Doppler flowmetry (LDF) has long been considered a gold standard for non-invasive assessment of skin microvascular function. Due to the laser Doppler (LD) microcirculatory signal’s complex biological and physiological context, using spectral analysis is advisable to extract as many of the signal’s properties as feasible. Spectral analysis can be performed using either a classical Fourier transform (FT) technique, which has the disadvantage of not being able to localize a signal in time, or wavelet analysis (WA), which provides both the time and frequency localization of the inspected signal. So far, WA of LD microcirculatory signals has revealed five characteristic frequency intervals, ranging from 0.005 to 2 Hz, each of which being related to a specific physiological influence modulating skin microcirculatory response, providing for a more thorough analysis of the signals measured in healthy and diseased individuals. Even though WA is a valuable tool for analyzing and evaluating LDF-measured microcirculatory signals, limitations remain, resulting in a lack of analytical standardization. As a more accurate assessment of human skin microcirculation may better enhance the prognosis of diseases marked by microvascular dysfunction, searching for improvements to the WA method is crucial from the clinical point of view. Accordingly, we have summarized and discussed WA application and its limitations when evaluating LD microcirculatory signals, and presented insight into possible future improvements. We adopted a novel strategy when presenting the findings of recent studies using WA by focusing on frequency intervals to contrast the findings of the various studies undertaken thus far and highlight their disparities.
Volatile metabolome and floral transcriptome analyses reveal the volatile components of strongly fragrant progeny of Malus × robusta
Authors: Li Guofang , Liu Jia , Zhang He , Jia Linguang , Liu Youxian , Li Jiuyang , Zhou Shiwei , Wang Pengjuan , Tan Ming , Shao Jianzhu
Published: January 2023

Floral fragrance is an important trait that contributes to the ornamental properties and pollination of crabapple. However, research on the physiological and molecular biology of the floral volatile compounds of crabapple is rarely reported. In this study, metabolomic and transcriptomic analyses of the floral volatile compounds of standard Malus robusta flowers (Mr), and progeny with strongly and weakly fragrant flowers (SF and WF, respectively), were conducted. Fifty-six floral volatile compounds were detected in the plant materials, mainly comprising phenylpropane/benzene ring-type compounds, fatty acid derivatives, and terpene compounds. The volatile contents were significantly increased before the early flowering stage (ES), and the contents of SF flowers were twice those of WF and Mr flowers. Odor activity values were determined for known fragrant volatiles and 10–11 key fragrant volatiles were identified at the ES. The predominant fragrant volatiles were methyl benzoate, linalool, leaf acetate, and methyl anthranilate. In the petals, stamens, pistil, and calyx of SF flowers, 26 volatiles were detected at the ES, among which phenylpropane/benzene ring-type compounds were the main components accounting for more than 75% of the total volatile content. Functional analysis of transcriptome data revealed that the phenylpropanoid biosynthesis pathway was significantly enriched in SF flowers. By conducting combined analyses between volatiles and differentially expressed genes, transcripts of six floral scent-related genes were identified and were associated with the contents of the key fragrant volatiles, and other 23 genes were potentially correlated with the key volatile compounds. The results reveal possible mechanisms for the emission of strong fragrance by SF flowers, and provide a foundation for improvement of the floral fragrance and development of new crabapple cultivars.
An empirical study on cultural identity measurement and its influence mechanism among heritage tourists
Authors: Fu Yuanbo , Luo Jian Ming
Published: January 2023

In the effort to integrate culture and tourism, an important strategy for the prosperity and sustainability of tourism, it is necessary to factor in tourists’ cultural identity and emotional interaction with cultural heritage to keep pace with the trends of cultural heritage tourism. Drawing on in-depth interviews and software such as Nvivo and Smart-PLS, this study aims to develop and verify cultural identity measures for cultural heritage tourists, construct a theoretical model of cultural identity, travel experience, place attachment, satisfaction, and revisit intention, and verify the theoretical relationship between these dimensions in the Archaeological Ruins of Liangzhu City. The results show that cultural identity is positively associated with travel experience and place attachment but not significantly associated with satisfaction; travel experience is positively associated with place attachment and revisit intention; place attachment is positively associated with satisfaction; place attachment is positively associated with revisit intention; satisfaction is positively associated with revisit intention. This qualitative and quantitative research enriches the theoretical achievements concerning cultural identity among cultural heritage tourists and proposes recommendations for management practice accordingly.
Effect of personality traits on matching dolls and their makers
Authors: Uetsuki Miki , Kimura Misako
Published: January 2023

Studies have shown that possessions such as cars and dogs resemble their owners, and products such as dolls resemble their makers even when students make them. We conducted three experiments to examine which part of the dolls resembled their makers. The results demonstrated that people match dolls to their makers when their eye regions were masked (Experiment 1), and the matching is possible even with the back views of the dolls (Experiment 2). These results may indicate people match dolls to their makers based on resemblances other than faces. Experiment 3 demonstrated that no effect of resemblance in personality traits was observed when dolls’ faces were visible. However, the resemblance of personality traits assumed by the dolls and their makers play an important role in the matching judgment when dolls’ faces were invisible (because of back views).
Consumer loneliness: A systematic review and research agenda
Authors: Huang Shanshan , Li Mingfei
Published: January 2023

Treading on the heels of the spread of the coronavirus, the “loneliness virus” has been capturing territories globally. Consumers are not immune to loneliness. Although academics and the general public have recognized the devastating effects of loneliness, the academic attention given to consumer loneliness (CL) is scattered and fragmentary. The purpose of this article is to systematically review the antecedents (predictors and alleviators) and consequences (consumer behaviors, emotions, preferences, attitudes, and cognition) of CL in various consumption contexts. This review also presents findings on CL as a mediator and moderator in consumer studies. This work adds to the growing body of CL literature by synthesizing the existing findings and knowledge. More importantly, we present a future research agenda by linking CL to significant research lines and detailed implications for practitioners in the marketplace.
AI-based chatbot micro-intervention for parents: Meaningful engagement, learning, and efficacy
Authors: Entenberg Guido A. , Mizrahi Sophie , Walker Hilary , Aghakhani Shirin , Mostovoy Karin , Carre Nicole , Marshall Zendrea , Dosovitsky Gilly , Benfica Daniellee , Rousseau Alexandra , Lin Grace , Bunge Eduardo L.
Published: January 2023

Introduction

Mental health issues have been on the rise among children and adolescents, and digital parenting programs have shown promising outcomes. However, there is limited research on the potential efficacy of utilizing chatbots to promote parental skills. This study aimed to understand whether parents learn from a parenting chatbot micro intervention, to assess the overall efficacy of the intervention, and to explore the user characteristics of the participants, including parental busyness, assumptions about parenting, and qualitative engagement with the chatbot.

Methods

A sample of 170 parents with at least one child between 2–11 years old were recruited. A randomized control trial was conducted. Participants in the experimental group accessed a 15-min intervention that taught how to utilize positive attention and praise to promote positive behaviors in their children, while the control group remained on a waiting list.

Results

Results showed that participants engaged with a brief AI-based chatbot intervention and were able to learn effective praising skills. Although scores moved in the expected direction, there were no significant differences by condition in the praising knowledge reported by parents, perceived changes in disruptive behaviors, or parenting self-efficacy, from pre-intervention to 24-hour follow-up.

Discussion

The results provided insight to understand how parents engaged with the chatbot and suggests that, in general, brief, self-guided, digital interventions can promote learning in parents. It is possible that a higher dose of intervention may be needed to obtain a therapeutic change in parents. Further research implications on chatbots for parenting skills are discussed.
Case report: New insights into persistent chronic pelvic pain syndrome with comorbid somatic symptom disorder
Authors: Huang JiChao , Zhong Yi , Duan Yu , Sun Jie
Published: January 2023

Chronic pelvic pain syndrome (CPPS) is generally defined as pain in the pelvic area that persisted for 3–6 months or longer. The pain can be constant or episodic and functionally disabling. Any dysfunction of the central nervous system can lead to central sensitization, which enhances and maintains pain as well as other symptoms that are mediated by the central nervous system. It occurs in subgroups of nearly every chronic pain condition and is characterized by multifocal pain and co-occurring somatic symptoms. Somatic symptom disorder (SSD) is defined as a condition in which having one or more somatic symptoms, such as excessive worries, pressure, and catastrophic events. These symptoms can be very disruptive to a patient’s life and can cause significant distress. SSD cases with severe symptoms frequently undergo repeated medical investigations and the symptoms often lead patients to seek emergency medical treatment and consult with specialists repeatedly, which is a source of frustration for patients and clinicians. Here we report a case that Asian female with persistent CPPS with comorbid SSD, who got in trouble for up to 8 years. This case reminds clinicians to pay excessive attention to the diagnosis of CPPS with comorbid SSD after recovery from acute COVID-19, with hope of raising awareness in the identification of SSD and present new insight into appropriate treatment for each woman who suffers from it.
Relationships between athletic ability and academic performance in primary school students: A 3-year follow-up study
Authors: Ji Hao Zong , Bai Cui Jin , Yun Yang , Dong Wu Xiang , Yi Qian Ze , Ping Wu Dan , Yi Tang , Xia Zheng Hong , Min Zhang Zhi , Long Xu Jing , Fei Zhang Teng , Ji Wang Jun , Zhen Li , Zhuang Gao , Ke Li Ying
Published: January 2023

Background

The aim of this study was to examine whether academic performance is associated with students' athletic ability in primary school.

Methods

A 3-year follow-up study was conducted among 1,136 Chinese students. Sit-up and jump rope testers were used to measure 1-min sit-ups and 1-min jump ropes, respectively. Meanwhile, the Pittsburgh Sleep Quality Scale and the Beck Depression Inventory were used to estimate sleep quality and depression levels. The end-of-semester examinations were used to evaluate students' academic performance during the follow-up period.

Results

After adjusting for confounders, the mean change in Chinese language performance for participants stratified by 1-min sit-ups at baseline was 0.35 (95% CI: −0.37 to 0.76) for level 1 (slowest), 0.52 (95% CI: −0.54 to 1.08) for level 2, and 1.72 (95% CI: 1.14 to 2.30) for level 3 (fastest) (P for trend = 0.003); the mean change in math scores was 0.28 (95% CI: −0.50 to 0.95) for level 1 (slowest), 0.95 (95% CI: 0.38 to 1.52) for level 2, and 1.41 (95% CI: 0.82 to 1.99) for level 3 (fastest) (P for trend = 0.048). The mean change in foreign language scores was −0.45 (95% CI: −0.99 to −0.93) for level 1 (slowest), −0.14 (95% CI: −0.44 to 0.41) for level 2, and 0.69 (95% CI: 0.25 to 1.13) for level 3 (fastest) (P for trend = 0.004). The mean change in Chinese language performance for participants stratified by 1-min jump ropes at the baseline was 0.30 (95% CI: −0.16 to 0.76) for level 1 (slowest), 1.09 (95% CI: 0.42 to 1.76) for level 2, and 1.74 (95% CI: 1.14 to 2.35) for level 3 (fastest) (P for trend = 0.001). The mean change in math scores was 0.41 (95% CI: −0.11 to 0.92) for level 1 (slowest), 1.44 (95% CI: 0.69 to 2.19) for level 2, and 1.43 (95% CI: 0.76 to 2.10) for level 3 (fastest) (P for trend = 0.019). The mean change in foreign language performance was −0.71 (95% CI: −1.08 to −0.33) for level 1 (slowest), 0.95 (95% CI: −0.40 to 1.50) for level 2, and 0.91 (95% CI: 0.41 to 1.41) for level 3 (fastest) (P for trend < 0.001).

Conclusion

This study suggests that participation in jump rope and sit-up exercises may positively affect students' academic performance.
Evaluation on the psychological adjustment and countermeasures of civil servants in public emergencies
Authors: Zhu Tianyi , Guo Shijie , Li Wenfeng , Li Zhuang
Published: January 2023

Public health emergencies are inevitable major development crises, and there are almost no omens of any emergency. The current social development would inevitably affect the psychological situation of civil servants. Grass roots civil servants have a wider range of tasks, more difficult working conditions and a more difficult environment. Under the strong social pressure, civil servants would also have negative factors such as fear and negative attitude. The mental health of grass-roots civil servants depends not only on the image and efficiency of the government, but also on creating a harmonious atmosphere and the quality of economic development. Therefore, people must pay attention to the psychological health of civil servants. It is mainly through psychological intervention and psychological adjustment to improve mental health. By analyzing the psychological characteristics of civil servants under emergencies and under pressure, and according to the importance of their coping ability under emergencies, this paper conducted corresponding psychological adjustment and psychological intervention to ensure the psychological health of civil servants, improve their ability to deal with public emergencies, and enable them to use correct and positive psychology to deal with public emergencies. It can be seen from the firefly algorithm that the prediction error value of the comprehensive quality of civil servants was declining, while the evaluation effect of the comprehensive quality was rising. The average value of the prediction error value of the comprehensive quality was about 0.49, and the average value of the evaluation effect of the comprehensive quality was about 0.73. In the whole process, the prediction error value of comprehensive quality decreased by 0.37, and the evaluation effect of comprehensive quality increased by 0.33. The comprehensive psychological quality and psychological adjustment ability of civil servants after psychological intervention were better than those before psychological intervention. The comprehensive psychological quality of civil servants after psychological intervention was 8.56% higher than that before psychological intervention, and the psychological adjustment ability was 8.47% higher than that before psychological intervention.
Effects of chronic stress on smartphone addiction: A moderated mediation model
Authors: Qiu Huake , Lu Hongliang , Pei Jiawei , Zhang Yajuan , Ma Yongjie , Xing Chen , Wang Xinlu , Zhu Xia
Published: January 2023

Introduction

Based on the compensatory Internet use theory and diathesis-stress model, the present study explores the effects of chronic stress on smartphone addiction (SPA). As intolerance of uncertainty and emotion-related variables are important factors that affect addictive behavior, we explore the mediating role of intolerance of uncertainty and the moderating role of emotion differentiation.

Methods

We conducted a questionnaire survey of 286 participants (13.64% female; Mage = 22.88; SD = 3.77; range = 17–39) on chronic stress, SPA, intolerance of uncertainty, and emotion differentiation. SPSS 28.0 was used to analyze the descriptive statistics and correlations and test the moderated mediation model.

Results

We find that (1) intolerance of uncertainty, SPA, and chronic stress are positively correlated with each other. Positive emotion differentiation is positively correlated with intolerance of uncertainty and negative emotion differentiation. (2) Intolerance of uncertainty plays a mediating role in chronic stress and SPA. (3) Positive emotion differentiation significantly moderates the relationship between chronic stress and SPA. Under the condition of low positive emotion differentiation, chronic stress is more effective in predicting SPA.

Discussion

These findings may contribute to intervention and prevention programs for SPA. Thus, the intervention and prevention of SPA can start from two directions-reduce the intolerance of uncertainty and enhance the ability to experience positive emotion differentiation.
Patient safety culture in neonatal intensive care units: A qualitative content analysis
Authors: Babaie Mohadese , Nourian Manijeh , Atashzadeh-Shoorideh Foroozan , Manoochehri Houman , Nasiri Malihe
Published: January 2023

Background

Safety culture, as an important and influential component of neonatal safety, can lay the ground for the provision of professional and quality care by creating a positive insight among workers. The present study aimed to explain the concept of safety culture and its dimensions from the perspective of the nurses and the physicians working in neonatal intensive care units (NICUs).

Methods

This qualitative directed content analysis study was carried out with 24 NICU physicians and nurses working in Tehran, Iran. These multicenter participants were selected through purposive sampling with maximum diversity in terms of demographic characteristics. The data was collected through in-depth semi-structured interviews and was analyzed using the deductive approach. The COREQ checklist was used for the comprehensive report of this study.

Results

The concept of patient safety culture in NICUs included achieving professional development, constructive interactions, organizational supportive climate, management's commitment to neonatal safety, planning and implementation of neonatal developmental care, which are extracted from 5 main categories, 10 generic categories and 21 sub-categories.

Conclusion

The dimensions of safety culture include procedures that, if promoted, could improve neonatal safety, reducing harm to neonates' health while expending less financial and human resources. Gaining knowledge of the status of these dimensions in wards and hospitals can give a purposeful direction to promote neonate health and policymaking.
Association between prothrombin time-international normalized ratio and prognosis of post-cardiac arrest patients: A retrospective cohort study
Authors: Tang Yiyang , Sun Jing , Yu Zaixin , Liang Benhui , Peng Baohua , Ma Jing , Zeng Xiaofang , Feng Yilu , Chen Qin , Zha Lihuang
Published: January 2023

Background

Cardiac arrest (CA) can activate blood coagulation. This study aimed to explore the potential prognostic value of prothrombin time–international normalized ratio (INR) in post-CA patients.

Methods

The clinical data of eligible subjects diagnosed with CA was extracted from the MIMIC-IV database as the training cohort. Restricted cubic spline (RCS), Kaplan–Meier (K-M) survival curve, and Cox regression analyses were conducted to elucidate the association between the INR and all-cause mortality of post-CA patients. Subgroup analysis, propensity score matching (PSM), and inverse probability of treatment (IPTW) were also conducted to improve stability and reliability. Data of the validation cohort were collected from the eICU database, and logistic-regression analyses were performed to verify the findings of the training cohort.

Results

A total of 1,324 subjects were included in the training cohort. A linear correlation existed between INR and the risk of all-cause death of post-CA patients, as shown in RCS analysis, with a hazard ratio (HR) >1 when INR exceeded 1.2. K-M survival curve preliminarily indicated that subjects with INR ≥ 1.2 presented lower survival rate and shorter survival time, and the high level of INR was independently associated with 30-day, 90-day, 1-year, and in-hospital mortalities, with multivariate-adjusted HR of 1.44 (1.20, 1.73), 1.46 (1.23, 1.74), 1.44 (1.23, 1.69), and 1.37 (1.14, 1.64), respectively. These findings were consistent and robust across the subgroup analysis, PSM and IPTW analyses, and validation cohort.

Conclusions

We systematically and comprehensively demonstrated that elevated INR was associated with increased short- and long-term all-cause mortality of post-CA patients. Therefore, elevated INR may be a promising biomarker with prognosis significance.
How can green credit decrease social health costs? The mediating effect of the environment
Authors: Rong Yanbo , Hu Jinyan
Published: January 2023

Green credit plays an important role in environmental protection and residents' health. This paper discusses the impact path of green credit on social health costs with the help of a quantile regression. The implementation of a green credit policy can decrease social health costs in China, and green credit works best in the economically developed Eastern region. As the quantile increases, so gradually does the absolute value of the green credit coefficient. This result proves that for provinces with rich per capita financial health expenditures, green credit plays a greater role in decreasing social costs, a conclusion also supported by our robustness test. In addition, we find that environmental pollution plays a mediating role in the path of green credit affecting health, and this finding is verified in the green credit and health general equilibrium model. Based on these findings, the government should encourage the active innovation of green credit products, and the banking industry should develop personalized green credit products for specific pollutant types or industries while decreasing government pressure.
Being with other animals: Transitioning toward sustainable food futures
Authors: Nieuwland Joachim , Meijboom Franck L. B.
Published: January 2023

How do non-human animals (hereafter animals) fit into sustainable food futures? This question prompts ethical reflection. However, especially in times of transformative change, one should not overlook ontological assumptions before engaging in ethics. We follow up on the work of the late Australian philosopher Val Plumwood as she prominently made this move to the ontological level when considering the edibility of animals. As she invites one (1) to listen to animals as well as (2) to embody one's own edibility, salient ontological assumptions about how humans relate to other animals, and the rest of reality, rise to the surface. While Plumwood also developed a modest ethical framework to address animal edibility, her ontological approach is highlighted here, especially as it appears to point toward moral relativism. Plumwood's ontological approach is further developed, notably by unraveling the dualism between self and other. Doing so results in a more non-conceptual way of relating to other animals. As a genuinely interdependent way of engaging with reality, it appears most relevant to considering what role animals might have in sustainable food futures.
Global Epidemiological Features of Human Monkeypox Cases and Their Associations With Social-Economic Level and International Travel Arrivals: A Systematic Review and Ecological Study
Authors: Du Min , Sun Huimin , Zhang Shimo , Yuan Jie , Yan Wenxing , Liu Qiao , Qin Chenyuan , Liu Min , Liu Jue
Published: January 2023

Objectives: We aimed to evaluate global epidemiological features of human monkeypox (mpox) cases and their associations with social-economic level and international travel arrivals.

Methods: We estimated the pooled value by random-effects models. Then, we conducted an ecological study to evaluate the relationship of confirmed cases with social-economic indices and international travel arrivals using correlation analyses.

Results: The average age (2022: 35.52, 95% CI [28.09, 42.94] vs. before 2022: 18.38, 95% CI [14.74, 22.02]) and comorbidity rate (2022: 15.7%, 95% CI [8.9%, 22.4%] vs. before 2022: 14.9%, 95% CI [8.5%, 21.3%]) of mpox cases in the 2022 human mpox outbreak were significantly higher than those of cases before 2022. During the 2022 mpox outbreak, the proportion of men who have sex with men (MSM) was high (79.8%, 95% CI [65.5%, 94.2%]). The number of confirmed mpox cases in 2022 significantly correlated with high social-economic levels and international travel arrivals (all p < 0.05).

Conclusion: Our findings highlighted the importance of early surveillance and timely detection in high-risk populations, including older people, MSM, and travelers, which is crucial to curb the wide transmission of mpox.
Inverse Reinforcement Learning as the Algorithmic Basis for Theory of Mind: Current Methods and Open Problems
Authors: Ruiz-Serra Jaime , Harré Michael S.
Published: January 2023

Theory of mind (ToM) is the psychological construct by which we model another’s internal mental states. Through ToM, we adjust our own behaviour to best suit a social context, and therefore it is essential to our everyday interactions with others. In adopting an algorithmic (rather than a psychological or neurological) approach to ToM, we gain insights into cognition that will aid us in building more accurate models for the cognitive and behavioural sciences, as well as enable artificial agents to be more proficient in social interactions as they become more embedded in our everyday lives. Inverse reinforcement learning (IRL) is a class of machine learning methods by which to infer the preferences (rewards as a function of state) of a decision maker from its behaviour (trajectories in a Markov decision process). IRL can provide a computational approach for ToM, as recently outlined by Jara-Ettinger, but this will require a better understanding of the relationship between ToM concepts and existing IRL methods at the algorthmic level. Here, we provide a review of prominent IRL algorithms and their formal descriptions, and discuss the applicability of IRL concepts as the algorithmic basis of a ToM in AI.
Acknowledgment to the Reviewers of Acoustics in 2022
Authors:   Acoustics Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Exploring the Barriers to the Adoption of Climate-Smart Irrigation Technologies for Sustainable Crop Productivity by Smallholder Farmers: Evidence from South Africa
Authors: Serote Batizi , Mokgehle Salmina , Senyolo Grany , du Plooy Christian , Hlophe-Ginindza Samkelisiwe , Mpandeli Sylvester , Nhamo Luxon , Araya Hintsa
Published: January 2023

Climate change continues to impact the livelihoods of smallholder farmers due to low adaptive capacity. In South Africa, the challenge is exacerbated by water scarcity and shortened crop-growing seasons. Climate-smart irrigation innovative technologies (CSIT) enhance smallholder farmers’ resilience to climate change. However, there is still a limited level of effective adoption and usage of these technologies in smallholder communities. This study investigated the barriers affecting the adoption of CSIT in rural areas of the Vhembe and Capricorn districts in Limpopo Province, South Africa. We explored the farmers’ socioeconomic factors extracted from farmers’ perceptions of CSIT-specific attributes. A multi-stage randomized sampling technique was used to select 100 smallholder farmers (SHF). Data analyzed by descriptive statistics such as percentages and frequency distribution are presented in graphs and tables. According to the findings, insufficient communication channels, a lack of financial availability, unstable land tenure systems, and insufficient training are the main obstacles to implementing CSIT. There is a need for policy and decision-makers to improve the communication channels for disseminating agro-meteorological information to the intended beneficiaries.
Long-Term Impact of Boron Addition at Various Dosages to a Groundnut-Cabbage System on Crop Yield and Boron Dynamics in Typic Haplustepts
Authors: Kumar Dileep , Patel Khusvadan C. , Shukla Arvind K. , Behera Sanjib K. , Ramani Vinubhai P. , Suthar Bhavin , Patel Ravi A.
Published: January 2023

The addition of boron (B) fertilizers to soils with low B content is required for augmenting crop yield. Therefore, it is imperative to have knowledge about the impact of long-term B addition at various dosages on crop yield and soil-B dynamics. A field experiment of a 6-year duration was carried out at Anand Agricultural University, Gujarat, India to study the influence of long-term B fertilization in the groundnut (Arachis hypogaea L.)-cabbage (Brassica oleracea var. capitata) cropping system in different rates and frequencies on yield of crops and soil-B dynamics. The direct effect of B addition on groundnut yield and the residual effect on succeeding cabbage crop yield was eval-uated. The treatments of the experiment encompassed various combinations of three frequencies and four rates of B application including one control (no B application). The application of B at different rates and frequencies significantly increased groundnut and cabbage yield in comparison to yield attained under the control. The addition of 1.0 kg B ha−1 in alternate years was found op-timum for enhancing the yield of groundnut and cabbage crops grown on study soil. Boron appli-cation enhanced B content in groundnut pod, haulm, cabbage and available B in soil. Optimal available B content in soil was 1.25 mg kg−1 for both groundnut pod and cabbage-head yield. The application of B with different rates and frequencies significantly enhanced B fractions in soil. The content of different fractions improved with the increase in rates of B application. The percentage contribution of various B fractions towards total B content followed the order: readily soluble B (0.43 to 0.55%) < specifically adsorbed B (0.74 to 0.98%) < organically bound B (0.70 to 1.55%) < ox-ide bound B (1.26 to 3.11%) < residual boron B (93 to 96.8%). Path analysis revealed the highest contribution of total boron towards groundnut-pod yield with a coefficient value of 4.30. Whereas oxide-bound boron fraction contributed to the maximum extent with a coefficient value of 0.91 towards cabbage-head yield. This information will be useful for B management in the ground-nut-cabbage cropping system grown on studied soil.
Acknowledgment to the Reviewers of Agriculture in 2022
Authors:   Agriculture Editorial Office
Published: January 2023

High-quality academic publishing is built on rigorous peer review [...]
Identification of Resistance to the Corn Weevil (Sitophilus zeamais M.) in Mexican Maize Races (Zea mays L.)
Authors: Jiménez-Galindo José Cruz , Castillo-Rosales Adán , Castellanos-Pérez Gloria , Orozco-González Francisco , Ortega-Ortega Adalberto , Padilla-Chacón Daniel , Butrón Ana , Revilla Pedro , Malvar Rosa Ana
Published: January 2023

Sitophilus zeamais (Motsch.) (Coleoptera: Curculionidae) has a global distribution and is one of the most important post-harvest pests of maize (Zea mays L.). Some Mexican maize races could be a novel source of resistance against S. zeamais to improve commercial maize, generating lines, varieties, and hybrids with resistance to the pest. These are original races from the center of origin of maize and have been exposed to selection pressure from S. zeamais and other pests for thousands of years, which probably resulted in some type of resistance. We studied the resistance of Mexican maize races to S. zeamais focusing on antixenosis, antibiosis, and tolerance. Antibiosis reduces the survival and reproduction of the insect or prolongs the time between generations, whereas antixenosis reduces the rate of initial and successive accumulation of the insect population. Obligate-antibiosis and free-choice bioassays were performed, and in those experiments, resistance traits and the consumption by S. zeamais were measured. The most resistant accession showed high adult mortality and fewer adults in the 1st generation, where the number of emerged adults is an ideal trait to evaluate the level of maize resistance to the pest. Net consumption (in grams) is the most economically important trait because it indicates the gross amount lost in a store, while yield losses (percentage of consumption) allow for studying tolerance. The type of endosperm did have an influence on the resistance/tolerance to S. zeamais. The flint varieties showed significantly higher mortality of adults before entering the seed, a lower quantity of emerged adults of the first generation in the obligate-antibiosis bioassay, and lower net consumption and percentage in both bioassays. In general, the varieties of the races Cristalino de Chihuahua, Apachito, and Azul showed high levels of resistance, with the Cristalino-079 (flint) and Azul (floury) accessions also being tolerant, and low levels of consumption by S. zeamais. Both could be used in breeding programs to reduce losses caused by S. zeamais.
The Yield-Forming Role of Nitrogen in Rice in the Growing Seasons with Variable Thermal Conditions
Authors: Zhang Jianwei , Zhou Yan , Wu Longmei , Xu Lei , Xu Cong , Liang Dong , Ding Yanfeng , Zhang Yongchun , Wang Jidong , Li Ganghua
Published: January 2023

A reduced basal and increased topdressing fertilizer rate (RBIT) can usually increase rice yield, but whether this practice alleviates the impact of poor weather on rice production is unknown. Thus, the effect of three integrated RBIT treatments (RBITs, including RBIT alone, RBIT in combination with straw incorporation (RBITS) or a reduced fertilizer rate (RBITR)) on rice growth and nutritional status under different weathers was investigated in a 9-year experiment. Conventional fertilization (CF) was the control. We found that daytime temperature and light (DTL) after heading were the main meteorological factors limiting rice yield increases. RBITs did not affect rice yield under High-DTL, compared with CF, but RBITS significantly increased rice yield under Low-DTL. Compared with High-DTL, the positive effect of RBIT and RBITR on the N concentration and proportion in vegetative organs under Low-DTL was higher than the K concentration in vegetative organs, but RBITS showed the opposite trend. Regression analysis indicated that the harvest index had stronger correlations with the N concentration (negative), K concentration (positive), and N/K (negative) in vegetative organs under Low-DTL than under High-DTL. Our findings suggested that RBITS could improve rice adaptability to daytime temperature and light changes after heading by balancing crop nutritional status (N/K).
Utilization of Cooked Cassava and Taro as Alternative Feed in Enhancing Pig Production in Ecuadorian Backyard System
Authors: Valverde Lucio Alfredo , Gonzalez-Martínez Ana , Rodero Serrano Evangelina
Published: January 2023

Pork production in Ecuador is of significant economic and nutritional importance. Many of these operations are family- or backyard-based and utilize alternative feed ingredients to reduce production costs. The current study aimed to determine the chemical composition of cooked cassava and taro, and to evaluate their inclusion in the feed of backyard pigs during the growth and fattening phases. A total of 42 castrated pigs from two geographic locations in Ecuador were studied over a period of 100 days, during which their weight and measurements were recorded at three-week intervals. At the end of the experiment, ileum samples were collected from the slaughtered pigs in order to calculate the apparent digestibility of the feed. The crude protein levels of cassava and taro were found to be 3.2% and 2.1%, respectively. The combination of cooked cassava and taro was found to be a suitable replacement for corn, with the best results observed in the group receiving a diet incorporating 21% each of cassava and taro. Analysis of the ileal content also revealed that this group exhibited the highest nitrogen assimilation from the diet.
Human–Animal Bond Generated in a Brief Animal-Assisted Therapy Intervention in Adolescents with Mental Health Disorders
Authors: Rodrigo-Claverol Maylos , Manuel-Canals Marta , Lobato-Rincón Luis Lucio , Rodriguez-Criado Natalia , Roman-Casenave Maite , Musull-Dulcet Elisabet , Rodrigo-Claverol Esther , Pifarré Josep , Miró-Bernaus Yvette
Published: January 2023

Background: The human–animal bond is crucial for the proper development of animal-assisted therapy (AAT) sessions. However, in specific cases such as in AAT focused on psychiatric patients who are admitted to acute units, there is only a short period of time available to establish this bond. Objectives: To assess the degree of HAB generated after two AAT sessions in adolescents admitted to acute psychiatry units. Methods: A prospective multicenter cohort study aimed at adolescents aged 13 to 17 years admitted to the acute child and adolescent psychiatry unit of three hospitals. Intervention: Two weekly 1 h group sessions of AAT with therapy dogs. Main outcome: The Center for the Study of Animal Wellness Pet Bonding Scale Survey (CSAWPB). Results: One hundred and fourteen adolescents participated. A positive perception of the dog was generated, achieving a good level of bonding and attachment. Conclusions: The results obtained make it possible to affirm that a short period of time is enough to establish a good HAB between patients and therapy dogs. This study aims to contribute to the study of non-pharmacological interventions as a complement to pharmacological treatments in adolescents with mental health disorders.