bluuebunny/crossref_metadata_2025 huggingface dataset:
Far-Red Absorbing Rhodopsins, Insights From Heterodimeric Rhodopsin-Cyclases
Authors: Broser Matthias
Published: January 2022

The recently discovered Rhodopsin-cyclases from Chytridiomycota fungi show completely unexpected properties for microbial rhodopsins. These photoreceptors function exclusively as heterodimers, with the two subunits that have very different retinal chromophores. Among them is the bimodal photoswitchable Neorhodopsin (NeoR), which exhibits a near-infrared absorbing, highly fluorescent state. These are features that have never been described for any retinal photoreceptor. Here these properties are discussed in the context of color-tuning approaches of retinal chromophores, which have been extensively studied since the discovery of the first microbial rhodopsin, bacteriorhodopsin, in 1971 (Oesterhelt et al., Nature New Biology, 1971, 233 (39), 149–152). Further a brief review about the concept of heterodimerization is given, which is widely present in class III cyclases but is unknown for rhodopsins. NIR-sensitive retinal chromophores have greatly expanded our understanding of the spectral range of natural retinal photoreceptors and provide a novel perspective for the development of optogenetic tools.
The Exercising Brain: An Overlooked Factor Limiting the Tolerance to Physical Exertion in Major Cardiorespiratory Diseases?
Authors: Marillier Mathieu , Gruet Mathieu , Bernard Anne-Catherine , Verges Samuel , Neder J. Alberto
Published: January 2022

“Exercise starts and ends in the brain”: this was the title of a review article authored by Dr. Bengt Kayser back in 2003. In this piece of work, the author highlights that pioneer studies have primarily focused on the cardiorespiratory-muscle axis to set the human limits to whole-body exercise tolerance. In some circumstances, however, exercise cessation may not be solely attributable to these players: the central nervous system is thought to hold a relevant role as the ultimate site of exercise termination. In fact, there has been a growing interest relative to the “brain” response to exercise in chronic cardiorespiratory diseases, and its potential implication in limiting the tolerance to physical exertion in patients. To reach these overarching goals, non-invasive techniques, such as near-infrared spectroscopy and transcranial magnetic stimulation, have been successfully applied to get insights into the underlying mechanisms of exercise limitation in clinical populations. This review provides an up-to-date outline of the rationale for the “brain” as the organ limiting the tolerance to physical exertion in patients with cardiorespiratory diseases. We first outline some key methodological aspects of neuromuscular function and cerebral hemodynamics assessment in response to different exercise paradigms. We then review the most prominent studies, which explored the influence of major cardiorespiratory diseases on these outcomes. After a balanced summary of existing evidence, we finalize by detailing the rationale for investigating the “brain” contribution to exercise limitation in hitherto unexplored cardiorespiratory diseases, an endeavor that might lead to innovative lines of applied physiological research.
A Looming Spatial Localization Neural Network Inspired by MLG1 Neurons in the Crab Neohelice
Authors: Luan Hao , Fu Qinbing , Zhang Yicheng , Hua Mu , Chen Shengyong , Yue Shigang
Published: January 2022

Similar to most visual animals, the crab Neohelice granulata relies predominantly on visual information to escape from predators, to track prey and for selecting mates. It, therefore, needs specialized neurons to process visual information and determine the spatial location of looming objects. In the crab Neohelice granulata, the Monostratified Lobula Giant type1 (MLG1) neurons have been found to manifest looming sensitivity with finely tuned capabilities of encoding spatial location information. MLG1s neuronal ensemble can not only perceive the location of a looming stimulus, but are also thought to be able to influence the direction of movement continuously, for example, escaping from a threatening, looming target in relation to its position. Such specific characteristics make the MLG1s unique compared to normal looming detection neurons in invertebrates which can not localize spatial looming. Modeling the MLG1s ensemble is not only critical for elucidating the mechanisms underlying the functionality of such neural circuits, but also important for developing new autonomous, efficient, directionally reactive collision avoidance systems for robots and vehicles. However, little computational modeling has been done for implementing looming spatial localization analogous to the specific functionality of MLG1s ensemble. To bridge this gap, we propose a model of MLG1s and their pre-synaptic visual neural network to detect the spatial location of looming objects. The model consists of 16 homogeneous sectors arranged in a circular field inspired by the natural arrangement of 16 MLG1s' receptive fields to encode and convey spatial information concerning looming objects with dynamic expanding edges in different locations of the visual field. Responses of the proposed model to systematic real-world visual stimuli match many of the biological characteristics of MLG1 neurons. The systematic experiments demonstrate that our proposed MLG1s model works effectively and robustly to perceive and localize looming information, which could be a promising candidate for intelligent machines interacting within dynamic environments free of collision. This study also sheds light upon a new type of neuromorphic visual sensor strategy that can extract looming objects with locational information in a quick and reliable manner.
A Mixed-Method Approach to Develop and Validate an Integrated Food Literacy Tool for Personalized Food Literacy Guidance
Authors: Boedt Tessy , Steenackers Nele , Verbeke Joke , Vermeulen Astrid , De Backer Charlotte , Yiga Peter , Matthys Christophe
Published: January 2022

Background

Food literacy refers to all practicalities associated with healthy eating. Current food literacy tools are limited in practical use in clinical practice. Therefore, an integrated food literacy tool (IFLT) to assess food literacy and to personalize food literacy guidance was developed and validated.

Methods

Following an iterative process, a food literacy framework was developed and food literacy goals were defined. A corresponding food literacy screener (FLS) to assess food literacy was developed along with an algorithm to provide personalized food literacy guidance based on the food literacy assessment. Content validation of the FLS was assessed by a panel of experts, measuring item and scale content validity index (I/S-CVI) and by the target population in semi structured interviews with 15 adults of reproductive age. Subsequently, an online cross-sectional survey was conducted among 114 adults of reproductive age to evaluate the validity of the FLS. Construct validity was examined against both the validated healthy eating and weight self-efficacy scale and against a food frequency questionnaire assessing healthy eating self-efficacy (HESE) and diet quality, respectively. Reliability was assessed with a two-week test-retest. Pearson correlation tests were conducted.

Results

An IFLT consisting of a FLS and corresponding algorithm to personalize food literacy guidance by prioritizing food literacy goals was developed. The IFLT includes 24 food literacy goals, addressed by 17 FLS items. Every item received a weighting factor based on theory and expert opinion to prioritize food literacy goals according to personal needs. Content validity revealed that the FLS was rated relevant by experts (S-CVI = 0.93) and well-understood by the target population. The FLS has a good construct validity as it was positively correlated with diet quality (r = 0.536, p < 0.001) and with HESE (r = 0.685, p < 0.001). It also showed a good test-retest reliability (r = 0.721, p < 0.001).

Conclusion

The newly developed IFLT is a practically applicable, context specific theory-and expert-based dual purpose tool to assess food literacy and to personalize food literacy guidance by prioritizing individuals' food literacy goals to their needs.
The Clinical Aspects and Prognostic Factors Concerning Survival in Patients With Recurrent Cervical Cancer After Radical Hysterectomy and Adjuvant Chemoradiotherapy
Authors: Zhu Hui-Ting , Yan Wen-Juan , Gao Yu-Hua
Published: January 2022

Purpose

To investigate the recurrence patterns and prognostic factors of patients with recurrent cervical cancer after radical hysterectomy with node dissection (RHND) followed by adjuvant radiotherapy (RT)/concurrent chemoradiotherapy (CCRT).

Methods

The medical records of 153 patients with pre-operative International Federation of Gynecology and Obstetrics stage IB-IIA cervical cancer, who were treated with RHND followed by adjuvant RT/CCRT at the Liaoning Cancer Hospital between January 1, 2012 and May 31, 2018, were retrospectively analyzed.

Results

The median disease progression-free survival time was 16 months, and 75.2% (115/153) of patients had a relapse within two years. The survival of patients with multi-site relapse was significantly lower in comparison to those with relapse in a single site (p < 0.001). The survival rate of patients with distant metastasis (DM) and combined recurrence (DM with localregional recurrence [LR]) was significantly lower than that of patients with only LR (p = 0.006, p < 0.001). Furthermore, the survival rate of patients with combined recurrence was significantly lower than that of patients with only DM (p = 0.046). Multivariate analysis showed that resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after disease relapse, and early disease relapse were independent prognostic factors associated with poor survival.

Conclusion

Most of the cervical cancer patients who received initial RHND followed by adjuvant RT/CCRT had a relapse within two years. Resection margin involvement, para-aortic and common iliac lymph node metastasis, DM, no treatment after recurrence, and early disease relapse were found to be prognostic factors in patients with recurrent cervical cancer after RHND followed by adjuvant RT/CCRT.
Relapsed Refractory Hodgkin Lymphoma and Brentuximab Vedotin-Bendamustine Combination Therapy as a Bridge to Transplantation: Real-World Evidence From a Middle-Income Setting and Literature Review
Authors: Radhakrishnan Vivek S. , Bajaj Rajat , Raina Vasundhara , Kumar Jeevan , Bhave Saurabh J. , Sukumaran Nair Reghu K. , Nag Arijit , Arun Indu , Zameer Lateef , Dey Debdeep , Arora Neeraj , Parihar Mayur , Das Jayanta , Achari Rimpa B. , Mishra Deepak K. , Chandy Mammen , Nair Reena
Published: January 2022

Introduction

Despite high cure rates with standard treatment, 30% patients with Hodgkin lymphoma develop relapsed or refractory (R/R) disease. Salvage therapy followed by autologous hematopoietic cell transplantation (HCT) is considered standard of care. Brentuximab Vedotin (Bv) in combination with Bendamustine (B) has been tested in the salvage setting with promising results.

Materials and Methodology

We conducted a single centre retrospective chart review of patients who received BBv salvage therapy to determine its activity and safety in patients with R/R classical Hodgkin lymphoma (HL). Between May 2011- December 2019, 179 patients were diagnosed with R/R HL.

Results

Thirty patients received BBv [median age: 30 (15-59) years, females (n=15)]. Primary refractory disease in 19 patients (63%), and 26 patients (87%) had advanced stage at treatment. Most patients received BBv after 2 prior lines of therapy [n=16 (53%)]. The median number of cycles of BBv were 3 (1-6). The number of BBv cycles delivered as outpatient was 63%. The most common Grade III/IV hematological adverse event was neutropenia [n=21, (70%)], while grade III/IV non-hematological toxicities included infections in 4 (13%), neuropathy in 4(13%), skin rash in 2 (7%), GI toxicities in 3 (10%) and liver dysfunction in 2 (7%) patients. The ORR and CR rates were 79% and 62%, respectively. Seventeen patients (57%) underwent an autologous HCT and 8 (26%) underwent an Allogeneic HCT (all haploidentical). The median follow up time from BBv administration was 12 months. Six patients died: 2 = disease progression, and 4 = non-relapse causes (Infection and sepsis = 2, GVHD=2). In addition to this, one patient progressed soon after HCT and another patient relapsed 22 months post HCT. Three year Overall survival (OS) and Event free survival (EFS) probability post-BBv treatment was 75% and 58%, respectively. OS and EFS analysis based on response (viz., CMR) to BBv demonstrated that patients in CMR had better survival probability [93% (p=0.0022) 3yr-OS and 72% (p=0.038) 3yr-EFS probability].

Conclusions

BBv is an active and well-tolerated salvage treatment for patients with R/R HL, even in refractory and advanced settings. In middle-income settings, cost constraints and access determine patient uptake of this regimen.
Detecting QTL and Candidate Genes for Plant Height in Soybean via Linkage Analysis and GWAS
Authors: Wang Jiajing , Hu Bo , Jing Yuliang , Hu Xiping , Guo Yue , Chen Jiankun , Liu Yuxi , Hao Jianhui , Li Wen-Xia , Ning Hailong
Published: January 2022

Soybean is an important global crop for edible protein and oil, and plant height is a main breeding goal which is closely related to its plant shape and yield. In this research, a high-density genetic linkage map was constructed by 1996 SNP-bin markers on the basis of a recombinant inbred line population derived from Dongnong L13 × Henong 60. A total of 33 QTL related to plant height were identified, of which five were repeatedly detected in multiple environments. In addition, a 455-germplasm population with 63,306 SNP markers was used for multi-locus association analysis. A total of 62 plant height QTN were detected, of which 26 were detected repeatedly under multiple methods. Two candidate genes, Glyma.02G133000 and Glyma.05G240600, involving in plant height were predicted by pathway analysis in the regions identified by multiple environments and backgrounds, and validated by qRT-PCR. These results enriched the soybean plant height regulatory network and contributed to molecular selection-assisted breeding.
Common and Specific Characteristics of Adolescent Bipolar Disorder Types I and II: A Combined Cortical Thickness and Structural Covariance Analysis
Authors: Kuang Liangfeng , Gao Weijia , Long Zhiliang , Cao Weifang , Cui Dong , Guo Yongxin , Jiao Qing , Qiu Jianfeng , Su Linyan , Lu Guangming
Published: January 2022

Background

By calculating cortical thickness (CT) and cortical structural covariance (SC), we aimed to investigate cortical morphology and cortical inter-regional correlation alterations in adolescent bipolar disorder type I (BD-I) and type II (BD-II) patients.

Methods

T1-weighted images from 36 BD-I and 22 BD-II patients and 19 healthy controls (HCs) were processed to estimate CT. CT values of the whole brain were compared among three groups. Cortical regions showing CT differences in groups were regarded as seeds for analyzing cortical SC differences between groups. The relationship between CT and clinical indices was further assessed.

Results

Both BD groups showed cortical thinning in several frontal and temporal areas vs. HCs, and CT showed no significant difference between two BD subtypes. Compared to HCs, both BD groups exhibited reduced SC connections between left superior frontal gyrus (SFG) and right postcentral gyrus (PCG), left superior temporal gyrus (STG) and right pars opercularis, and left STG and right PCG. Compared with HCs, decreased SC connections between left STG and right inferior parietal gyrus (IPG) and right pars opercularis and right STG were only observed in the BD-I group, and left PCG and left SFG only in the BD-II group. CT of right middle temporal gyrus was negatively correlated with number of episodes in BD-II patients.

Conclusions

Adolescent BD-I and BD-II showed commonly decreased CT while presenting commonly and distinctly declined SC connections. This study provides a better understanding of cortical morphology and cortical inter-regional correlation alterations in BD and crucial insights into neuroanatomical mechanisms and pathophysiology of different BD subtypes.
Chinese Younger Parents' Quality of Life During the COVID-19 Pandemic: Do Job Changes and Family Conflicts Matter?
Authors: Liu Xiaohan , Bai Yashuang , Huang Ning , Ahmed Farooq , Shahid Muhammad , Guo Jing
Published: January 2022

The quality of life (QoL) might have been decreased owing to social disruptions in daily life and basic functioning after the coronavirus disease (COVID-19) pandemic. This work aims to examine the relationship between job changes, family conflicts, and QoL among parents during COVID-19 in China. We recruited 1,209 adults through an online cross-sectional survey in China during the COVID-19 lockdown from April 21 to April 28, 2020. Convenient and cluster sampling methods were used to recruit parents. The global health items in the Patient-Reported Outcomes Measurement Information System (PROMIS) were used as a measurement for QoL. Data were mainly analyzed by multiple linear regression with SPSS. Both marital conflict (β = −0.243, p < 0.001) and parent–child conflict (β = −0.119, p = 0.001) were negatively associated with the QoL among parents during the lockdown. Job changes moderated the relationship between marital conflict and QoL (β = −0.256, p = 0.022). In addition, the interaction effects of job changes and family conflict on QoL were significant only among fathers and one-child families. This study indicated that family conflict was a crucial factor correlated with QoL among young parents in the backdrop of the COVID-19 lockdown. Job changes could interact with marital conflict and parent–child conflict on the quality of life.
The Role of Tea Tree Oil in Alleviating Palmitic Acid-Induced Lipid Accumulation in Bovine Hepatocytes
Authors: Yang Tianyu , Ma Xiaoyu , Jiang Maocheng , Cheng Zhiqiang , Datsomor Osmond , Zhao Guoqi , Zhan Kang
Published: January 2022

Tea tree oil (TTO) plays an important role in lipid metabolism, alleviating the inflammatory responses. Fatty liver is associated with lipid accumulation in hepatocytes, leading to inflammation. However, there is very limited information on the effects of TTO on lipid accumulation, and inflammation in bovine hepatocytes. This study aimed to evaluate whether TTO alleviates palmitic acid (PA)-induced lipid accumulation in bovine hepatocytes. Hepatocytes isolated from mid-lactating Holstein cows were pretreated with 100 μM PA for 72 h. Cells were either pretreated with PA alone (PA group) or with PA followed by 0.00625% TTO treatment for 12 h (PT group). Expression of fatty acid oxidant genes increased (P < 0.05) while fatty acid synthesis genes decreased (P < 0.05) in the PT group compared with the PA group. PA treatment resulted in increased (P < 0.05) expression of tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6), but these increases were less in the PT group (P < 0.05). Compared to the PA group, expression of phosphorylated (p)-p65 and p-inhibitor κBα (p-IκBα) was suppressed (P < 0.05) by TTO treatment. TTO treatment limited (P < 0.05) the increase in intracellular reactive oxygen species (ROS) and prevented (P < 0.05) a reduction in mitochondrial membrane potential observed in response to PA treatment. Expression of endoplasmic reticulum (ER) stress genes was reduced (P < 0.05) in the PT group compared with the PA group. Our results suggest that TTO treatment attenuates the effects of PA in hepatocytes, leading to fatty acid oxidation, decreased fatty acid synthesis, suppressed inflammatory response, and reduced ER stress. Taken together, the results of this study suggest that TTO treatment may be a promising therapeutic approach to imbalanced lipid homeostasis, inflammation and ER stress in dairy cows shortly before and after calving.
Energy-Efficient Trajectory Optimization for UAV-Enabled Cellular Communications Based on Physical-Layer Security
Authors: Yuan Ziwei , Yang Yanping , Wang Dong , Ma Xiaoping
Published: January 2022

Low-altitude cellular-enabled Unmanned Aerial Vehicles (UAVs) provide potential supplementary platforms to assist air-to-ground cooperative communication. This paper investigates a joint safety information interaction scheme for a UAV-enabled network, which involves the complex constraints of three-dimensional trajectory planning, average energy efficiency optimization, and physical-layer security. Specifically, by modeling the UAV and the Ground Station (GS) as the transmit sources, we define the secure Energy Efficiency (EE) as the ratio of the total secrecy rate to the energy consumption of the whole system. Then, to achieve secure and energy-efficient communication in eavesdropping scenarios, we formulated the optimization problem as maximizing both the uplink/downlink secure EE of the system, subject to the constraints of the UAV’s mobility and the allowable transmit power. For this highly coupled non-convex problem, a composite solution of joint fractional programming, alternate optimization, the bisection method, and the interior-point method is proposed to obtain the achievable EE. Simulation and performance analysis gave the conclusions that the joint optimization of trajectory and power allocation is capable of maximizing the information secure EE. Additionally, the secure EE increases with the increase of the average transmit power, which finally tends to be stable.
Assessment of the Impact of Material Selection on Aviation Sustainability, from a Circular Economy Perspective
Authors: Markatos Dionysios N. , Pantelakis Spiros G.
Published: January 2022

Climate change and global warming pose great sustainability challenges to the aviation industry. Alternatives to petroleum-based fuels (hydrogen, natural gas, etc.) have emerged as promising aviation fuels for future aircraft. The present study aimed to contribute to the understanding of the impact of material selection on aviation sustainability, accounting for the type of fuel implemented and circular economy aspects. In this context, a decision support tool was introduced to aid decision-makers and relevant stakeholders to identify and select the best-performing materials that meet their defined needs and preferences, expressed through a finite set of conflicting criteria associated with ecological, economic, and circularity aspects. The proposed tool integrates life-cycle-based metrics extending to both ecological and economical dimensions and a proposed circular economy indicator (CEI) focused on the material/component level and linked to its quality characteristics, which also accounts for the quality degradation of materials which have undergone one or more recycling loops. The tool is coupled with a multi-criteria decision analysis (MCDA) methodology in order to reduce subjectivity when determining the importance of each of the considered criteria.
Antioxidant Activity of Resveratrol Diastereomeric Forms Assayed in Fluorescent-Engineered Human Keratinocytes
Authors: Bononi Ilaria , Tedeschi Paola , Mantovani Vanessa , Maietti Annalisa , Mazzoni Elisa , Pancaldi Cecilia , Brandolini Vincenzo , Tognon Mauro
Published: January 2022

Resveratrol is a powerful antioxidant molecule. In the human diet, its most important source is in Vitis vinifera grape peel and leaves. Resveratrol exists in two isoforms, cis- and trans. The diastereomeric forms of many drugs have been reported as affecting their activity. The aim of this study was to set up a cellular model to investigate how far resveratrol could counteract cytotoxicity in an oxidant agent. For this purpose, a keratinocyte cell line, which was genetically engineered with jelly fish green fluorescent protein, was treated with the free radical promoter Cumene hydroperoxide. The antioxidant activity of the trans-resveratrol and its diastereomeric mixture was evaluated indirectly in these treated fluorescent-engineered keratinocytes by analyzing the cell number and cell proliferation index. Our results demonstrate that cells, which were pre-incubated with resveratrol, reverted the oxidative damage progression induced by this free radical agent. In conclusion, fluorescent-engineered human keratinocytes represent a rapid and low-cost cellular model to determine cell numbers by studying emitted fluorescence. Comparative studies carried out with fluorescent keratinocytes indicate that trans-resveratrol is more efficient than diastereomeric mixtures in protecting cells from the oxidative stress.
SBT (Composed of Panax ginseng and Aconitum carmichaeli) and Stigmasterol Enhances Nitric Oxide Production and Exerts Curative Properties as a Potential Anti-Oxidant and Immunity-Enhancing Agent
Authors: Han Na-Ra , Kim Kyeoung-Cheol , Kim Ju-Sung , Park Hi-Joon , Ko Seong-Gyu , Moon Phil-Dong
Published: January 2022

Immune dysregulation is a risk factor for several diseases, including infectious diseases. Immunostimulatory agents have been used for the treatment of immune dysregulation, but deleterious adverse effects have been reported. The present study aims to establish the anti-oxidant and immunity-enhancing effects of Sambu-Tang (SBT), composed of Panax ginseng and Aconitum carmichaeli, and stigmasterol (Stig), an active compound of SBT. Immune-related factors were analyzed in RAW264.7 macrophage cells, mouse primary splenocytes, and the serum and spleen of cyclophosphamide-induced immunosuppressed mice. Results showed that the production levels of nitric oxide (NO) and expression levels of inducible NO synthase and heme oxygenase-1 were increased following SBT or Stig treatment in RAW264.7 cells. SBT or Stig increased the production levels of G-CSF, IFN-γ, IL-12, IL-2, IL-6, and TNF-α and induced the activation of NF-κB in RAW264.7 cells. SBT or Stig promoted splenic lymphocyte proliferation and increased splenic NK cell cytotoxic activity. In addition, SBT or Stig enhanced the levels of IFN-γ, IL-12, IL-2, IL-6, or TNF-α in the serum and spleen of the immunosuppressed mice. SBT or Stig increased the superoxide dismutase activity in the spleen. Collectively, SBT and Stig possess anti-oxidant and immunomodulatory activities, so they may be considered effective natural compounds for the treatment of various symptoms caused by immune dysregulation.
The Most Important Risk Factors Affecting the Physical Health of Orthodontists: A Pilot Study
Authors: Trakiniene Giedre , Rudzinskaite Monika , Gintautaite Greta , Smailiene Dalia
Published: January 2022

The purpose of this study is to evaluate the most frequent problems in the physical health of orthodontists and to determine which factors in the working environment of dental specialists have the most important influence on the physical health of orthodontic practitioners. This survey was conducted using a questionnaire that was distributed among orthodontists and dental specialists. The questionnaire consisted of 42 questions: 36 closed-ended questions with 1 or multiple possible answer choices, and 6 open-ended questions. The survey was carried out online and responses were collected anonymously. The study included 266 questionnaires completed by orthodontists and dental practitioners with a mean age of 34.5 ± 10.1 years. The results showed that 71% of orthodontists and 90% of dental practitioners experienced different types of pain during their workday and after work. The most common health problems among orthodontists were shoulder and neck pain. Orthodontists’ health status was better than dentists’. Usually, orthodontists experience shoulder and neck pain. The factors that helped orthodontists avoid health disorders were: the use of individually adjustable backrests and saddle-type chairs, assuming a neutral sitting position, keeping work equipment as close as possible, and breaks in between patients during work.
Our Cherished Moments of Involuntary Realism: Charles Harrison, Modernism, and Art Writing
Authors: Moonie Stephen
Published: January 2022

In May 1969, Charles Harrison reviewed Morris Louis’ exhibition at the Waddington Galleries in London. Months later, he helped to install the exhibition When Attitudes Become Form at the Institute of Contemporary Arts. Harrison also wrote the catalogue text, published in Studio International. Those two texts marked a significant point in Harrison’s career. They were indicative of his disillusionment with modernist criticism, and of his burgeoning interest in the work of post-minimal and conceptual art. In this respect, the two essays mark a transition from modernism to post-modernism in the space between a formalist analysis of the art object and a more dispersed field of artistic practice, where a changed relationship between art practice, criticism, and curating was taking place. However, in the 2000s, Harrison came to reflect upon this cardinal moment. Harrison referred to his recollected experiences of the late 1960s as a ‘cherished moment of involuntary realism’, opening up issues around art writing which remain pertinent to the practice of art history.
Platelets’ Role in Dentistry: From Oral Pathology to Regenerative Potential
Authors: Bianchi Serena , Torge Diana , Rinaldi Fabiola , Piattelli Maurizio , Bernardi Sara , Varvara Giuseppe
Published: January 2022

Platelets are a cellular subgroup of elements circulating in the bloodstream, responsible for the innate immunity and repairing processes. The diseases affecting this cellular population, depending on the degree, can vary from mild to severe conditions, which have to be taken into consideration in cases of minor dental procedures. Their secretion of growth factors made them useful in the regenerative intervention. The aim of this review is to examine the platelets from biological, examining the biogenesis of the platelets and the biological role in the inflammatory and reparative processes and clinical point of view, through the platelets’ pathology and their use as platelets concentrates in dental regenerative surgery.
Development of a BIM and IoT-Based Smart Lighting Maintenance System Prototype for Universities’ FM Sector
Authors: Fialho Beatriz Campos , Codinhoto Ricardo , Fabricio Márcio Minto , Estrella Júlio Cezar , Ribeiro Cairo Mateus Neves , Bueno Julio Mendonça dos Santos , Torrezan João Pedro Doimo
Published: January 2022

Reactive maintenance (RM) is a core service of the operation and maintenance (O&M) phase, the most prolonged and costly within the building lifecycle. RM is characterised by inefficient asset information and communication management, impacting critical FM problems and users’ experience. Building information modelling (BIM) and Internet of things (IoT) has enabled the development of digital twins, moving facilities management (FM) from a reactive approach towards a predictive one. Although previous studies have investigated the application of such technologies to FM, there is a lack of understanding on procedural issues related to its implementation in FM and RM. This research aimed to characterise strategies and decisions involved in prototyping a BIM and IoT-based smart-lighting maintenance system and identify its potential impacts on universities’ maintenance processes. The adopted research strategy and data collection methods involved prototyping, questionnaires, and interviews. The results show a high level of complexity in converging maintenance needs and technological abilities for FM and the importance of procedures and standards at organisational and industry levels. Moreover, it evidenced that the automation of functions and the centralisation of information enabled by BIM and IoT can optimise service provision, generate environmental and efficiency gains, and improve users’ safety and satisfaction.
Small Non-Coding RNAs in Leukemia
Authors: Balatti Veronica , Croce Carlo M.
Published: January 2022

In 2020, more than 60,500 people were diagnosed with leukemia in the USA, and more than 23,000 died. The incidence of leukemia is still rising, and drug resistance development is a serious concern for patients’ wellbeing and survival. In the past two decades, small non-coding RNAs have been studied to evaluate their functions and possible role in cancer pathogenesis. Small non-coding RNAs are short RNA molecules involved in several cellular processes by regulating the expression of genes. An increasing body of evidence collected by many independent studies shows that the expression of these molecules is tissue specific, and that their dysregulation alters the expression of genes involved in tumor development, progression and drug response. Indeed, small non-coding RNAs play a pivotal role in the onset, staging, relapse and drug response of hematological malignancies and cancers in general. These findings strongly suggest that small non-coding RNAs could function as biomarkers and possible targets for therapy. Thus, in this review, we summarize the regulatory mechanisms of small non-coding RNA expression in different types of leukemia and assess their potential clinical implications.
ZnO Transducers for Photoluminescence-Based Biosensors: A Review
Authors: Rodrigues Joana , Pereira Sónia O. , Zanoni Julia , Rodrigues Carolina , Brás Mariana , Costa Florinda M. , Monteiro Teresa
Published: January 2022

Zinc oxide (ZnO) is a wide bandgap semiconductor material that has been widely explored for countless applications, including in biosensing. Among its interesting properties, its remarkable photoluminescence (PL), which typically exhibits an intense signal at room temperature (RT), arises as an extremely appealing alternative transduction approach due to the high sensitivity of its surface properties, providing high sensitivity and selectivity to the sensors relying on luminescence output. Therefore, even though not widely explored, in recent years some studies have been devoted to the use of the PL features of ZnO as an optical transducer for detection and quantification of specific analytes. Hence, in the present paper, we revised the works that have been published in the last few years concerning the use of ZnO nanostructures as the transducer element in different types of PL-based biosensors, namely enzymatic and immunosensors, towards the detection of analytes relevant for health and environment, like antibiotics, glucose, bacteria, virus or even tumor biomarkers. A comprehensive discussion on the possible physical mechanisms that rule the optical sensing response is also provided, as well as a warning regarding the effect that the buffer solution may play on the sensing experiments, as it was seen that the use of phosphate-containing solutions significantly affects the stability of the ZnO nanostructures, which may conduct to misleading interpretations of the sensing results and unreliable conclusions.
The Evolution of Finger Counting between Kindergarten and Grade 2
Authors: Poletti Céline , Krenger Marie , Dupont-Boime Justine , Thevenot Catherine
Published: January 2022

In this longitudinal study, we aimed at determining whether children who efficiently use finger counting are more likely to develop internalized arithmetic strategies than children who are less efficient. More precisely, we analyzed the behavior of 24 kindergarteners aged between 5 and 6 years who used their fingers to solve addition problems, and we were interested in determining the evolution of their finger counting strategies towards mental strategies after 2 years (Grade 2). Our results show that kindergarteners who were the most proficient in calculating on fingers were the more likely to have abandoned this strategy in Grade 2. This shows that the use of efficient finger counting strategies early during development optimizes the shift to mental strategies later on during school years. Moreover, children who still use their fingers to solve additions in Grade 2 present lower working memory capacities than children who had already abandoned this strategy.
Modified Maximum Entropy Method and Estimating the AIF via DCE-MRI Data Analysis
Authors: Amini Farsani Zahra , Schmid Volker J.
Published: January 2022

Background: For the kinetic models used in contrast-based medical imaging, the assignment of the arterial input function named AIF is essential for the estimation of the physiological parameters of the tissue via solving an optimization problem. Objective: In the current study, we estimate the AIF relayed on the modified maximum entropy method. The effectiveness of several numerical methods to determine kinetic parameters and the AIF is evaluated—in situations where enough information about the AIF is not available. The purpose of this study is to identify an appropriate method for estimating this function. Materials and Methods: The modified algorithm is a mixture of the maximum entropy approach with an optimization method, named the teaching-learning method. In here, we applied this algorithm in a Bayesian framework to estimate the kinetic parameters when specifying the unique form of the AIF by the maximum entropy method. We assessed the proficiency of the proposed method for assigning the kinetic parameters in the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), when determining AIF with some other parameter-estimation methods and a standard fixed AIF method. A previously analyzed dataset consisting of contrast agent concentrations in tissue and plasma was used. Results and Conclusions: We compared the accuracy of the results for the estimated parameters obtained from the MMEM with those of the empirical method, maximum likelihood method, moment matching (“method of moments”), the least-square method, the modified maximum likelihood approach, and our previous work. Since the current algorithm does not have the problem of starting point in the parameter estimation phase, it could find the best and nearest model to the empirical model of data, and therefore, the results indicated the Weibull distribution as an appropriate and robust AIF and also illustrated the power and effectiveness of the proposed method to estimate the kinetic parameters.
A Fault-Tolerant Transmission Scheme in SDN-Based Industrial IoT (IIoT) over Fiber-Wireless Networks
Authors: Zhou Qinbin , Zhao Taotao , Chen Xiaomin , Zhong Yuesheng , Luo Heng
Published: January 2022

Driven by the emerging mission-critical and data-intensive applications in industrial intelligent manufacturing, the software-defined network (SDN) based fiber-wireless access network (FiWi) is attracting considerable attention thanks to its capability of central control and large bandwidth. However, the heterogeneity of the network leads to new challenges, since the packet loss can be caused either by the poor channel quality of wireless links or network component failures. A novel and adaptive mechanism combining sparse random linear network coding with parallel transmission (SNC-PT) is proposed to achieve the fault-tolerance against high packet loss rate and any network element malfunction. We illustrate the benefits of using the SNC-PT mechanism to improve fault tolerance by characterizing the network performance with respect to the completion time and goodput along with its relationship to channel quality and node failures. We show that significant performance gains can be obtained in comparison with conventional uncoded transmission based on transmission control protocol (TCP). The simulation results show that the SNC-PT mechanism is fault-tolerant, while it can significantly shorten the data transmission completion time to at least 12% of the baseline and increase the goodput by about 10% compared to other coding schemes such as random linear network coding.
Nutritional Function and Flavor Evaluation of a New Soybean Beverage Based on Naematelia aurantialba Fermentation
Authors: Sun Tao , Jiang Hao , Yang Kai , Li Xingkai , Wang Shiyu , Yao Haoyu , Wang Rui , Li Sha , Gu Yian , Lei Peng , Xu Hong , Sun Dafeng
Published: January 2022

The soy beverage is a healthy product rich in plant protein; however, its unpleasant flavor affects consumer acceptance. The aim of this study was to determine the feasibility of using Naematelia aurantialba as a strain for the preparation of fermented soybean beverages (FSB). Increases in Zeta potential, particle size, and viscosity make soy beverages more stable. We found that nutrient composition was increased by fermenting N. aurantialba, and the antioxidant activity of soybean beverages significantly increased after 5 days of fermentation. By reducing the content of beany substances such as hexanal and increasing the content of 1-octen-3-ol, the aroma of soybean beverages fermented by N. aurantialba changed from “beany, green, and fatty” to “mushroom and aromatic”. The resulting FSB had reduced bitterness but considerably increased sourness while maintaining the fresh and sweet taste of unfermented soybean beverages (UFSB). This study not only provides a theoretical basis for the market promotion of FSB but also provides a reference for basidiomycetes-fermented beverages.
The Promise and Challenges of Determining Recombinant Bovine Growth Hormone in Milk
Authors: Raux Axel , Bichon Emmanuelle , Benedetto Alessandro , Pezzolato Marzia , Bozzetta Elena , Le Bizec Bruno , Dervilly Gaud
Published: January 2022

Recombinant bovine growth hormone (rbGH) is produced in large quantities and widely used in a number of countries worldwide to stimulate milk production in dairy animals. The use of this compound in animal production is strictly regulated by food safety directives in force, in particular in the European Union (EU). Although analytical strategies for the detection of rbGH in blood have been successfully reported over the past 15 years, they do not fully answer the expectations of either competent authorities or industrials that would expect measuring its occurrence directly in the milk. As a matrix of excretion but also of consumption, milk appears indeed as the matrix of choice for detecting the use of rbGH in dairy animals. It also allows large volumes to be collected without presenting an invasive character for the animal. However, rbGH detection in milk presents several challenges, mainly related to the sensitivity required for its detection in a complex biological matrix. This review article presents the specific difficulties associated with milk and provides an overview of the analytical strategies reported in the literature and whether they concern indirect or direct approaches to the detection of rbGH administration to animals, with applications either for screening or confirmation purposes.
Color, Starch Digestibility, and In Vitro Fermentation of Roasted Highland Barley Flour with Different Fractions
Authors: Zhao Zixuan , Ming Jian , Zhao Guohua , Lei Lin
Published: January 2022

Highland barley (HB) is commonly milled into flour for direct consumption or further processed with other food formulations. Nevertheless, the association between milling and HB flour properties remains lacking. This work studied the effect of particle sizes (coarse, 250–500 μm; medium, 150–250 μm; fine, <150 μm) on physicochemical and nutritional properties of raw and sand-roasted HB flour. Gelatinization enthalpy decreased with increasing particle sizes of raw HB flour, while no endothermic transitions were observed in sand-roasted flour. Sand roasting destroyed starch granules and decreased short-range molecular order. Starch digestibility increased while total short-chain fatty acids (SCFAs) production decreased with decreasing particle sizes in all samples. The relative crystallinity of sand-roasted HB flour decreased by 80–88% compared with raw samples. Sand roasting raised in vitro starch digestibility, while total SCFAs during in vitro fecal fermentation decreased. Sand-roasted HB flour with particle sizes <150 μm had the highest starch digestibility (94.0%) but the lowest production of total SCFAs (1.89–2.24 mM). Pearson’s correlation analysis confirmed the relationship between the nutritional qualities of HB flour and milling.
Low-Temperature and UV Irradiation Effect on Transformation of Zirconia -MPS nBBs-Based Gels into Hybrid Transparent Dielectric Thin Films
Authors: Muşat Viorica , Herbei Elena Emanuela , Anghel Elena Maria , Jank Michael P. M. , Oertel Susanne , Timpu Daniel , Frangu Laurenţiu
Published: January 2022

Bottom-up approaches in solutions enable the low-temperature preparation of hybrid thin films suitable for printable transparent and flexible electronic devices. We report the obtainment of new transparent PMMA/ZrO2 nanostructured -building blocks (nBBs) hybrid thin films (61–75 nm) by a modified sol-gel method using zirconium ethoxide, Zr(OEt)4, and 3-methacryloxypropyl trimethoxysilane (MPS) as a coupling agent and methylmethacrylate monomer (MMA). The effect of low-temperature and UV irradiation on the nBBs gel films is discussed. The thermal behaviors of the hybrid sols and as-deposed gel films were investigated by modulated thermogravimetric (mTG) and differential scanning calorimetry (DSC) analysis. The chemical structure of the resulted films was elucidated by X-ray photoelectron (XPS), infrared (IR) and Raman spectroscopies. Their morphology and crystalline structure were observed by scanning electron microscopy (SEM), high-resolution transmission electron microscopy (HR-TEM), and grazing incidence X-ray diffraction. The cured films show zirconia nanocrystallites of 2–4 nm in the hybrid matrix and different self-assembled structures for 160 °C or UV treatment; excellent dielectric behavior, with dielectric constant values within 6.7–17.9, depending on the Zr(OEt)4:MMA molar ratio, were obtained.
Potential Association between the Use of Anabolic Steroids and COVID-19 Infection
Authors: Althobaiti Yusuf S. , Alzahrani Mohammed S. , Alhumayani Shahad M. , Assiry Shaima A. , Aljuaid Hadeel F. , Algarni Majed A.
Published: January 2022

Anabolic androgenic steroids (AASs) are synthetic analogs of testosterone that can affect the immune system. Bodybuilders and sportsmen are at risk of abusing AASs. The aim of this study was to investigate the association between AASs use and coronavirus disease (COVID-19). This cross-sectional study included adults aged 18 years and above. Between 16 April and 23 June 2021, gym-attending participants completed an online survey. Multivariable analysis was performed using multiple logistic regression to identify factors associated with COVID-19 diagnosis and severity. Current use of AASs was reported in 7.5% of the 520 study participants. Approximately 20% of the study participants reported that they had contracted COVID-19, approximately half of whom reported moderate to severe disease. Contracting COVID-19 was reported more frequently by current users than by non-current users (35.90% vs. 18.92%, p = 0.011). Multivariable analysis revealed that contracting COVID-19 was nearly five times more likely among current users of AASs than among non-current users (OR = 4.89, 95% CI: 1.69–14.13). Current use of AASs was also associated with greater odds of moderate to severe COVID-19 disease (OR = 3.71, 95% CI: 1.04–13.21). Our findings suggest that the use of AASs could be an underlying risk factor for COVID-19 severity.