bluuebunny/crossref_metadata_2025 huggingface dataset:
Why women with breast cancer presented late to health care facility in North-west Ethiopia? A qualitative study
Authors: Tesfaw Aragaw , Alebachew Wubet , Tiruneh Mulu
Published: December 2020

Background

Although early diagnosis is a key determinant factor for breast cancer survival, delay in presentation and advanced stage diagnosis are common challenges in low and middle income countries including Ethiopia. Long patient delays in presentation to health facility and advanced stage diagnosis are common features in breast cancer care in Ethiopia but the reasons for patient delays are not well explored in the country. Therefore we aimed to explore the reasons for patient delay in seeking early medical care for breast cancer in North-west Ethiopia.

Methods

A qualitative study was conducted from November to December 2019 using in-depth interviews from newly diagnosed breast cancer patients in the two comprehensive specialized hospitals in North West Ethiopia. Verbal informed consent was taken from each participant before interviews. A thematic content analysis was performed using Open Code software version 4.02.

Results

Lack of knowledge and awareness about breast cancer, cultural and religious beliefs, economic hardships, lack of health care and transportation access, fear of surgical procedures and lack of trusts on medical care were the major reasons for late presentation of breast cancer identified from the patient’s narratives.

Conclusions

The reasons for late presentation of patients to seek early medical care for breast cancer had multidimensional nature in Northwest Ethiopia. Health education and promotion programs about breast cancer should be designed to increase public awareness to facilitate early detection of cases before advancement on the existing health care delivery system.
Heritagization of street art as a theatrical performance: The case study of Dolk’s artworks conservation in Bergen, Norway
Authors: Nomeikaite Laima
Published: December 2020

In recent years, individual street artworks have been framed as cultural heritage. However, attempts to integrate street artworks and graffiti into formal heritage frameworks have not provided solutions to the philosophical and practical problems associated with their preservation. Rather than focusing on street artworks as passive objects to be conserved, preserved or managed, this research analyses the conservation of Dolk’s street artworks as an example of lively theatrical performance emerging from embodied actions, lived processes and social practices. Applying non-representational theory, heritage studies and cultural studies, the research argues that the conservation of street artworks is not passive, but active – a process in which humans, social media and artworks, themselves, are active, relational and equally important actors contributing to ‘heritagization’. The case illustrates that acts of destruction – as well as social media debates and street art performances that oppose conventional heritage practices and commodification – can serve as stimuli for not only reconsidering the meanings and values of street art but also protecting the rights of city commons.
Graffiti is back in town: Critical approaches to visual and spatial practices in Berlin
Authors: Hoppe Ilaria
Published: December 2020

The article considers the critical potential of both graffiti and street art using Berlin as an example, where these forms of urban creativity have flourished. It offers an interdisciplinary, context-related analysis by combining visual and spatial theories, which highlight both their critical agency as well as their affirmative potential in processes of gentrification. In this way, the study takes up the question of Avramidis and Tsilimpounidi about what graffiti and street art actually do in urban space. Thus, they are understood as spatial and visual forms of critique and protest, as also historic positions within the discourses on architecture and the city show, where graffiti, in particular, appears as a critical term. This applies to the general notion of graffiti being a confrontation with the capitalist system and its hegemonic spectacle, as well as the abject view, comparing them with dirt within a racist discourse. Finally, these contestations of and within the democratic city dissolve themselves in the post-urban paradigm. This implies a notion of the city under complete private ownership and control where there is no place for dialectics anymore and the ‘urban’ is seen as a threat to society.
An architectural palimpsest: (Re)writing crisis-ridden Athens1
Authors: Avramidis Konstantinos
Published: December 2020

This article focuses on the Bank of Greece headquarters building in Athens, which has been a site of recurring political expression in contemporary crisis. It is based on a corpus of graffiti writings from the particular building gathered over the span of five years (2010–15), a rather politically dense period. Mapping the constant appearance, removal and reappearance of the writings through a series of architectural drawings, the aim of this article is to explore visual means of understanding graffiti as a palimpsestic phenomenon. The article is structured after the scale of the drawings – from the city scale, to the building and finally the surface – introducing an architectural method of reading and writing graffiti.
The spatial politics of street art in post-Revolution Egypt
Authors: El-Shewy Mohamed
Published: December 2020

This article is concerned with exploring the politics of street art and graffiti in Egypt in the aftermath of the uprising against former President Hosni Mubarak in 2011. Rather than viewing street art and graffiti as mere by-products of the revolutionary period, the article centres them as important elements of political and social struggle. I put forward a reading of Egypt’s street art and graffiti as sites of politics through both aesthetic and spatial approaches. To do so I draw on Jacques Rancière’s concept of ‘dissensus’, a term referring to a political and aesthetic process that creates new modes of perception and novel forms of political subjectivity. In various writings, Rancière argues that part of the work of ‘dissensus’ is the creation of spaces where political activity can take place. As spatially bound practices, street art and graffiti can allow a visible ‘dissensus’ to take place. Through a semiotic analysis of several street art and graffiti works, the article makes a further contribution to scholarship on Egypt’s revolutionary street art and graffiti scene. Instead of focusing on the figure of the ‘rebel artist’, I centre the works in relation to the history of Egyptian nationalism, and argue that we need to complicate our understanding of street art and graffiti’s potential as modes of resistance.
Re-imagining the everyday: Street art in an ‘urban village’, Delhi
Authors: Roy Sreejata , Chatterjee Mrityunjay
Published: December 2020

The proposed article questions how a group of women (age 15–20 years) from different ethnic backgrounds in working-class settlement in New Delhi, who individually and collectively tries to reclaim and create their own spaces through wall painting on the street. This is to respond and to adapt to the pressures of the constantly changing urban ecology, within the larger contemporary discourses and experiences of risk and vulnerability negotiated by them in public space. Thus the article foregrounds the ‘relational’ approach and collaborative ethic with the trajectory of ‘dialogue’ as key method within the socially engaged art project. The idea of reclaiming spaces to negotiate the changes of local ecology, which accommodates the change of perception of men regarding women in public, has been initiated through creating wall painting in the streets. A wall painting initiative evolved through series of discussion sessions with a group of young women in Khirki and Hauz Rani, an urban village in New Delhi. The idea was to paint a series of ordinary women doing daily activities and engaging in work that is customarily done by men in the locality. The intent was to draw men on the street into a dialogue about the gender equality in terms of the acceptance of women in male-associated professions, as well as a dialogue about the visibility of women in public spaces.
Ṯawra almar’a muš ‘awra. Feminismo árabe laico en países árabes y/o islámicos y Europa
Authors: García Lafuente María Isabel
Published: December 2020

En este artículo presentaremos de manera breve los vínculos entre los discursos de algunas feministas árabes muy conocidas en la actualidad sobre temas tan controvertidos como la laicidad o el uso del cuerpo como arma de batalla. Podemos considerarlas como las representantes de un movimiento que está tomando fuerza en países árabes y/o islámicos y también en Europa. Es un movimiento que lucha por los derechos de las mujeres sin amparar su discurso en ninguna religión, algo que estas feministas consideran indispensable para alcanzar el progreso social y la igualdad de género.
Reseña de: Evaristo, Bernardine. Niña, mujer, otras. Madrid: Alianza de Novelas, 2020. 496 pp. ISBN ebook: 978-84-9181-814-4
Authors: Alcañiz Moscardó Mercedes
Published: December 2020

Reseña de: Evaristo, Bernardine. Niña, mujer, otras. Madrid: Alianza de Novelas, 2020. 496 pp. ISBN ebook: 978-84-9181-814-4
Learning about Extraordinary Beings: Native Stories and Real Birds
Authors: Pierotti Raymond
Published: December 2020

Oral traditions of Indigenous American peoples (as well as those of other Indigenous peoples) have long been discussed with regard to their reliability as metaphorical accounts based upon historical knowledge. I explore this debate using stories to discuss the importance of the role of Corvidae in Indigenous knowledge traditions and how these stories convey information about important socioecological relationships. Contemporary science reveals that Corvids important in cultural traditions were companions to humans and important components of the ecology of the places where these peoples lived. Ravens, Crows, Jays, and Magpies are identified as having special roles as cooperators, agents of change, trickster figures, and important teachers. Canada (or Gray) Jays serve as trickster/Creator of the Woodland Cree people, Wisakyjak. Magpies won the Great Race around the Black Hills to determine whether humans would eat bison or vice versa. I analyze these stories in terms of their ecological meaning, in an effort to illustrate how the stories employ dramatic settings to encourage respect and fix relationships in the sociocultural memory of the people.
A beruházási projektek aggregált tőkeigénye = The Aggregate Capital Needs of Investment Projects
Authors: Illés Mária
Published: December 2020

A tanulmány abból indul ki, hogy a beruházási projektek értékelése során egyidejűleg szükséges figyelembe venni a projektben lekötött tőkét és a lekötési időt mint jövedelemtermelési lehetőséget. Definiálja a projekt aggregált tőkeigényének fogalmát és megszerkeszti a vonatkozó mérőszámot. Az aggregált tőkeigény új vállalatgazdasági kategória, mely a beruházási projektek értékelésének egy új megközelítését teszi lehetővé. A projekt aggregált tőkeigénye azt a tőkeösszeget jelenti, mely a projekt működtetéséhez annak teljes élettartama alatt szükséges. A három meghatározó tényező: a kezdőtőke, a megtérülési idő (illetőleg az élettartam) és a megtérülés gyorsasága. A számszerűsítéshez minden évre vonatkozóan meg kell határozni az adott évben lekötött tőkét, ami az adott évig még meg nem térült tőkerészt jelenti, majd ezek összegzése révén adódik az aggregált tőkeigény. A mértékegység egységnyi tőke egyévi lekötése. A tanulmány az összefüggések modellszerű levezetése mellett gazdag példaanyagot is tartalmaz. Az elemzés bővíti a nettó jelenérték tartalmára vonatkozó ismereteket, rávilágít az aggregált tőkeigény ismeretének fontosságára mind a nettó jelenérték, mind a belső kamatláb esetében. _____ The starting point of this paper is that in the evaluation process of investment projects necessary to take into account simultaneously the tied-up capital and tiedup time as the income-generating potential. For this, it defines a special content of aggregate capital needs of investment projects, and elaborates an index. The aggregate capital needs is a new business economics category, which provides a new aspect to evaluate investment projects. This means the amount of capital needed for the operation of the project during its full duration. Three factors determine the aggregate capital needs for investments projects. These are the amount of initial investment, the payback period (or the duration) and the rapidity of capital payback. The solution is to sum up the yearly tied-up capital, that is, the notreturned parts of the capital for each year. The measurement unit is one unit tied-up capital for one year. The paper formulates the main relationships as models and by way of explanation presents some examples. The analysis highlights the importance of considering the aggregate capital needs furthermore widens knowledge regarding the net present value and internal rate of return.
Költség- és időcsökkentési eljárások alkalmazása a projekttervezésben és a nyomon követésben = Application of cost and time reduction procedures in project planning and the follow-up
Authors: Kosztyán Zsolt Tibor
Published: December 2020

A válság okozta megszorítások a projektek költségvetését sem hagyták változatlanul. Nagyon sokszor nemcsak a jövőbeni projekttervek költségvetését kell átgondolni, hanem a már futó projektek költségvetését is újra kell szabni. E tanulmány ilyen esetekben nyújthat módszertani támogatást. A szerző ebben a kutatásban négy költség- és időcsökkentő módszert hasonlít össze. Ismerteti, hogy ezeket az eljárásokat milyen módon lehet ötvözni, illetve mikor, melyiket célszerű alkalmazni. Az eljárások között van olyan módszer, amely a hagyományos projektmenedzsment (pl. építési, beruházási projektek menedzselésének) eszköztárát gazdagítja, de találkozhatunk olyan eljárásokkal is, amelyek az agilis projektszemléleten alapuló módszerek körét szélesítik. A bemutatott módszerek nemcsak a hálótervezési, hanem a mátrixos projekttervezési eljárások esetén is alkalmazhatók. ____ Due to the effects of the crisis, budgets of present as well as future projects are decreasing steadily. In this study four different methods are introduced for minimising budget and time demands. These introduced methods support not only the traditional but also the agile project management. Furthermore these methods can be used not only in case of network planning, but also for matrix-based project planning.
A magyar fiatalok jellemzése pénzügyi attitűdjeik és magatartásuk mentén – Vizsgálat a felsőoktatásban tanulók pénzügyi attitűdjeiről és magatartásáról = Characterization of the Hungarian youth with their financial attitudes and behaviours – A survey about the financial behaviour and attitudes of students
Authors: Zsótér Boglárka , Béres Dániel , Németh Erzsébet
Published: December 2020

A pénzügyi piacok és termékek egyre komplexebbé válnak, ami együtt jár a pénzügyeket illető információs szakadék mélyülésével is – a lakosság egyre kevésbé képes pénzügyeiről körültekintő döntéseket hozni. Jelen tanulmány a magyar felsőoktatásban tanuló fiatalokat pénzügyi attitűdjeik mentén szegmentálja és jellemzi, annak érdekében, hogy hozzájáruljon a pénzügyi kultúra szintjét növelő programok sikerességéhez, legyen az állami indíttatású (pénzügyi edukáció) vagy a versenyszféra által vezérelt. A vizsgált fiatalok alapvetően három csoportba sorolhatók: (1) Konzervatívak, (2) Lázadók és (3) Tapasztaltak. A Konzervatívakra a stabil morális értékrend, alacsony kockázatvállalási hajlandóság jellemző, céljaik között egyaránt találunk rövid és hosszú távúakat is – informáltságuk, és ebből eredően pénzügyi ismeretszintjük alacsony, a hitelekkel szembeni attitűdjük negatív. A Lázadók csoportjára az „Élj a mának!” magatartás a jellemző, vagyis rövid távú céljaik vannak, kevésbé tudatosak, pénzügyi ismeretszintjük alacsony, ugyanakkor nyitottak az újdonságokra és a kockázatvállalási szintjük magasabb a másik két csoporténál. A Tapasztaltak csoportjára a tudatosság és a pénzügyi megfontoltság a jellemző – pénzügyi ismeretszintjük magasabb a másik két csoporténál. Náluk a hosszú távú célok dominálnak, de alacsony kockázatvállalási hajlandóság mellett. _____ Financial markets and financial instruments have become more and more complex in the last decades. Unfortunately, financial literacy of population cannot keep up with the innovation activity of financial sector. By segmenting and describing Hungarian young adults along their financial attitudes, the aim of this study is to provide recommendations to the programs aiming to enhance the development of financial literacy. According to the authors’ results, 18-25 year-old young adults can be categorized as (1) conservatives, (2) rebels and (3) experienced. Conservatives can be characterized by stable moral and values, low risktaking willingness and inappropriate financial knowledge. Both short and long term goals can be explored among their preferences. Conservatives have negative attitude to bank loans. The rebels can be described by the ancient Latin saying: “Carpe Diem”. They have short-term goals and the future financial stability is not an issue for them – their financial literacy is low. However, rebels are open-minded and their risk-taking willingness is greater than the other two group members. Despite of the low level of risk-taking willingness, the highest level of financial literacy is showed by the experienced group. They have long-term goals and are able to receive information about complex financial instruments.
REFLEXÕES ACERCA DAS APROXIMAÇÕES E DISTANCIAMENTOS NAS RELAÇÕES EDUCATIVAS ENTRE ALUNOS(AS) SURDOS(AS) E OUVINTES EM UMA ESCOLA MUNICIPAL DE JOÃO PESSOA-PB
Authors: DA SILVA GRACILEIDE ALVES , SINÉSIO MOURA RONNIE WESLEY , DORZIAT ANA
Published: December 2020

Este artigo problematiza algumas práticas de interação e elementos sociais/educacionais que contribuem com as aproximações e/ou distanciamentos entre alunos/as surdos/as e ouvintes em uma escola declarada inclusiva na cidade de João Pessoa/PB. Para tanto, fundamenta-se em reflexões sobre a política de inclusão e os Estudos Surdos. O procedimento metodológico envolveu observações, seguido de registros sobre a legitimação de identidades e diferenças em meio à luta por (re)significação social, especificamente, dos/as alunos/as surdos/as. Os resultados evidenciaram, simultaneamente, rupturas, resistências, tensões e desafios vividos pelos sujeitos protagonistas deste estudo, os quais demonstraram que a capacidade de construção de suas identidades se baseia em um processo de associação e/ou dissociação entre grupos surdos e ouvintes.
DESCARTE DO LIXO DE UM HOSPITAL PÚBLICO NO MUNICÍPIO DE COARI, ESTADO DO AMAZONAS, BRASIL
Authors: Almeida Célio dos Santos , Santos Helder Manuel da Costa , Góes Dartaguinan da Silva , Pachêco Vanusa Bezerra
Published: December 2020

Este trabalho trata-se de uma pesquisa realizada sobre o gerenciamento dos resíduos de um hospital público no município de Coari-AM com o objetivo de analisar o modo como os resíduos são descartados e verificar se os procedimentos estão em conformidade com as exigências legais das resoluções brasileiras que dispõem sobre o gerenciamento do lixo hospitalar. A pesquisa foi realizada na área externa do hospital onde foi observado os tipos de resíduos descartados na lixeira externa, a forma de armazenamento, segregação, identificação, coleta e transporte até a disposição final. A lixeira armazenava resíduos do Grupo A (infectantes), Grupo D (comum) e Grupo E (perfurocortantes) em sacos plásticos ou em caixas de papelão e que, posteriormente, eram despejados no lixão. Foi constatado que o hospital descumpre as orientações determinadas pela Resolução da Diretoria Colegiada n° 222/2018 da Agência Nacional de Vigilância Sanitária e Resolução n° 358/2005 do Conselho Nacional do Meio Ambiente sobre o descarte de seus resíduos.
FATORES GEOLÓGICOS E PEDOLÓGICOS QUE INFLUENCIAM NA PRODUTIVIDADE HÍDRICA DO SISTEMA AQUÍFERO SERRA GERAL (SASG) NA REGIÃO NORTE DO ESTADO DO PARANÁ
Authors: Peterlini Giselly , Pinese José Paulo Peccinini , Celligoi André
Published: December 2020

O aumento do uso das águas subterrâneas se contrasta com a deficiência no conhecimento do potencial dos aquíferos fraturados e dos fatores ambientais que contribuem para uma melhor produtividade hídrica. Considerados fatores influentes na produtividade, as Estruturas Intraderrames (E) – fraturas, vesículas e amígdalas – e a Espessura de Solo (S) foram analisadas com o objetivo de avaliar sua influência sobre a produtividade de poços que explotam o SASG no norte do Paraná. Foi calculada a quantidade de E presente nos perfis geológicos e observados os valores de S de 60 poços. Para avaliar a influência do tipo de E, foram criados três grupos de poços e comparados os dados de produtividade. Para avaliar a influência da quantidade de E e S na produtividade, aplicaram-se análises de correlação e de variância multivariada. O único grupo que apresentou correlação moderada com a vazão foi o grupo que apresentavam três tipos de estruturas no perfil. A S apresentou uma correlação muito baixa a baixa com a produtividade. As análises multivariadas confirmaram que a única variável influenciada por E e S é a vazão. Conclui-se que E e S exercem influência sobre a produtividade aquífera, sendo que E exerce maior influência que S.
ANÁLISE MULTICRITÉRIO PARA DETERMINAÇÃO DO ISOLAMENTO GEOGRÁFICO E DESENVOLVIMENTO EM ILHAS ESTUARINAS DO MUNICÍPIO DE BELÉM-PA
Authors: Quaresma Arley Martins , Szlafsztein Claudio Fabian
Published: December 2020

Os fluxos de desenvolvimento socioeconômico das ilhas amazônicas são fortemente relacionados por sua relevância, singularidade, e valor em relação aos caminhos de desenvolvimento dos centros urbanos. A distância física das ilhas do município de Belém-PA determina as unidades insulares a níveis de desenvolvimento territorial distintos. Este artigo propõe uma análise a partir de critérios pré-estabelecidos a fim de determinar o grau de isolamento e a relação de desenvolvimento das ilhas mais relevantes do município de Belém-PA. A metodologia para determinação do grau de isolamento levou em consideração dois indicadores: Acessibilidade e conectividade e suas respectivas variáveis. Contudo, o artigo examinará como o distanciamento físico do continente afeta a capacidade de uma ilha determinar seu próprio destino e curso de desenvolvimento. A parti dos resultados constatou-se que as ilhas mais isoladas se sustentam de diferentes condições de autonomia e desenvolvimento. As ilhas com menor grau de isolamento possuem ligações físicas e conectividade intensa, maneira pela qual reduzem o isolamento. Em tais ligações, as ilhas mais propensas ao desenvolvimento não são as mais próximas ao continente, mas as que possuem maiores ofertas de serviços aos ilhéus.
PADRÕES DE VIAGENS INTRAURBANAS PARA O TRABALHO E ESTABELECIMENTOS EDUCACIONAIS: EVIDÊNCIAS A PARTIR DO ESTUDO DE CASO DE UBERLÂNDIA - MG
Authors: Garrefa Fernando , Carvalho Flávia Fernandes , Elias Júlia Tavares de Sousa , Pinto Isabella Denadae de Campos
Published: December 2020

O presente artigo busca analisar os padrões de viagem considerando-se, a partir da habitação, os deslocamentos para o trabalho e estabelecimentos educacionais. Busca-se analisar as distâncias percorridas, e os modais de transporte na cidade de Uberlândia, MG. Para tal, recorreu-se à aplicação de questionários, posterior inserção em banco de dados georreferenciado para cálculo das distâncias e uso de software estatístico para análise de dados. Os resultados demonstraram que a medida em que aumenta a renda familiar e o nível de escolaridade, maior é a escolha pelo automóvel individual. Os dados também evidenciam uma ampliação constante e generalizada dos transportes motorizados individuais por meio de aplicativos, principalmente em faixas etárias de 19 a 29 anos. O trabalho mostra ainda que carros ou motos o meio de transporte mais utilizado para as viagens ao trabalho e para as viagens à escola pelo gênero masculino. Para as viagens à escola pelo gênero feminino, os meios de transporte são mais diversificados e combinados entre si. A partir das análises desenvolvidas espera-se contribuir com as decisões de planejamento urbano e formulação de políticas públicas de transporte. Também espera-se contribuir para a mitigação dos impactos causados pelos deslocamentos diários, derivados das viagens para trabalho e educação.
TOPOMORPHOLOGICAL COMPARTMENTS AND MORPHODYNAMICS OF AN URBAN STREAM WATERSHED, UBERABA, BRAZIL
Authors: Martins Neto Francisco Ferreira , Alexandre Felipe Ivonez Borges , Corradini Fabricio Anibal
Published: December 2020

A expansão urbana ocorrida no município de Uberaba (MG) a partir da década de 1970 mudou não apenas a vida da população local, mas também a fisiografia da área urbana devido à canalização dos principais rios urbanos. Alterações no escoamento superficial têm causado vários inconvenientes à população devido a eventos de inundação resultantes de períodos de fortes chuvas. Estudos recentes relataram associação entre o aumento da frequência e intensidade de tais eventos após a impermeabilização de áreas-chave reduzindo a infiltração de águas superficiais. O córrego das Lages é um deles. Está localizado no centro da cidade, constituindo um local de importância econômica e fluxos sociais altamente vulneráveis a inundações. Assim, é necessário investigar sua bacia hidrográfica para ajudar a entender melhor seus compartimentos topomorfológicos e morfodinâmicos, bem como analisar a influência dos processos de ocupação e antropização em sua dinâmica natural. Mapas representando áreas impermeabilizadas, limites de bacias hidrográficas, modelo de elevação digital e transectos foram gerados no QGIS 2.18, enquanto as características fisiográficas foram calculadas com base nos principais métodos disponíveis na literatura. Os aspectos acima mencionados indicaram que a bacia hidrográfica tem suscetibilidade natural a eventos de inundação. Foram identificados três compartimentos topomorfológicos.
Tutorial on the emergence of local substructure failures in the railway track structure and their renewal with existing and new methodologies
Authors: Eller Balázs , Fischer Szabolcs
Published: December 2020

The construction and maintenance of a railway track is an expensive process. Therefore, nowadays, except for advanced countries, considerable attention must be paid to apply the optimal maintenance of railway lines. In Hungary, until 2020 nearly 11% of railway tracks were renewed and rehabilitated from EU support, which means millions of Euros, i.e. billions of Hungarian Forints. It also follows from the support that planned preventive maintenance works must be performed on the renewed and rehabilitated lines. On the other hand, it takes away significant costs from the non-renewed (non-rehabilitated) lines maintenance works, but naturally, less money does not mean less failures, so cost-effective technologies are needed. A segment of maintenance is the local substructure problem(s). In this article, this segment will be mentioned from the development of the failures, through the applied technologies, to the possible new solutions like injection and the using of geosynthetic cementitious composite mats (so called GCCMs).
Effect of Dehydroepiandrosterone on Lipemia, Glucose Tolerance, Insulinemia, Insulin Binding to Erythrocytes in SHR/N-cp Lean Rats of Koletsky Type
Authors: Golda Věroslav , Hilgertová Jiřina
Published: December 2020

Experiments were performed in the genetically hypertensive lean males of Koletsky type. It was monitored the effect of dehydroepiandrosterone (DHEA) treatment on lipemia, glucose tolerance, insulinemia, insulin binding to erythrocytes, fat pads, body weight and pellet intake. DHEA was applied in two doses: 10 and 20 mg per kg b.w.,i.p., for 11 days when glucose tolerance was monitored and for 21 days when the remaining parameters were analyzed. DHEA shows dose dependent decrease in changes of body weight over injection period, in plasma triglycerides and total plasma cholesterol, decrease being most expressed under the higher dose. High as well low of DHEA decreases the sum of glycaemia obtained 30, 60, 120 and 180 min after glucose loading (area under the curve) i.e., DHEA alleviates genetically based glucose intolerance. DHEA induced hypophagia under the higher dose treatment. Insulin binding to erythrocytes was not influenced by DHEA.
Changes of Cholinesterase Activity in the Erythrocytes, Plasma, Diaphragm, Liver and Various Parts of the Brain in the Rabbit Following Transfusion of Erythrocytes with Soman Inhibited Acetylcholinesterase
Authors: Kassa Jiří , Bajgar Jiří , Fusek Josef
Published: December 2020

1. The changes of cholinesterase activity in rabbit blood, peripheral tissues and the central nervous system following transfusion of erythrocytes with soman inhibited acetylcholinesterase were demonstrated. 2. After incubation with soman for 0.5 or 24 h, erythrocytes without acetylcholinesterase activity were injected to intact rabbits and cholinesterase activity in the erythrocytes, plasma, diaphragm, liver and various parts of the brain were evaluated 24 h following blood-transfusion. 3. When erythrocytes were incubated with soman for 24 h, no changes of cholinesterase activity in the rabbit following blood-transfusion were observed with an exception of erythrocyte acetylcholinesterase. 4. When erythrocytes were incubated with soman for 0.5 h, a significant decrease in cholinesterase activity in the erythrocytes, plasma, diaphragm and liver following blood-transfusion was found. These data show that soman is able to release from erythrocytes and inhibit cholinesterase activities not only in vitro but also in vivo although the significant inhibition of cholinesterase activities by soman was only observed in the peripheral compartment.
Blocking mitochondrial pyruvate import in brown adipocytes induces energy wasting via lipid cycling
Authors: Veliova Michaela , Ferreira Caroline M , Benador Ilan Y , Jones Anthony E , Mahdaviani Kiana , Brownstein Alexandra J , Desousa Brandon R , Acín‐Pérez Rebeca , Petcherski Anton , Assali Essam A , Stiles Linsey , Divakaruni Ajit S , Prentki Marc , Corkey Barbara E , Liesa Marc , Oliveira Marcus F , Shirihai Orian S
Published: December 2020

Combined fatty acid esterification and lipolysis, termed lipid cycling, is an ATP‐consuming process that contributes to energy expenditure. Therefore, interventions that stimulate energy expenditure through lipid cycling are of great interest. Here we find that pharmacological and genetic inhibition of the mitochondrial pyruvate carrier (MPC) in brown adipocytes activates lipid cycling and energy expenditure, even in the absence of adrenergic stimulation. We show that the resulting increase in ATP demand elevates mitochondrial respiration coupled to ATP synthesis and fueled by lipid oxidation. We identify that glutamine consumption and the Malate‐Aspartate Shuttle are required for the increase in Energy Expenditure induced by MPC inhibition in Brown Adipocytes (MAShEEBA). We thus demonstrate that energy expenditure through enhanced lipid cycling can be activated in brown adipocytes by decreasing mitochondrial pyruvate availability. We present a new mechanism to increase energy expenditure and fat oxidation in brown adipocytes, which does not require adrenergic stimulation of mitochondrial uncoupling.
IRE1‐mediated miRNA maturation in macrophage phosphoinositide signaling
Authors: Avril Tony , Chevet Eric
Published: December 2020

Endoplasmic reticulum (ER) stress signaling has long been associated with various pathological states in particular with the development of diseases with an underlying inflammation, such as diabetes, liver or cardiovascular dysfunctions, and cancer. ER stress signaling is mediated by three stress sensors. The most evolutionarily conserved one, the inositol‐requiring enzyme 1 alpha (IRE1), transduces most of the signals through an endoribonuclease (RNase) activity toward RNAs including mRNAs and microRNAs (miRNAs). By exploring phosphoinositide signaling in human macrophages, Hamid and colleagues discovered a novel function of IRE1 RNase that through the cleavage of pre‐miR‐2317 generates a mature miR‐2317 independently of the canonical Dicer endonuclease to yield specific biological outcomes (Hamid et al, 2020).
Ectopic pregnancy and epithelial to mesenchymal transition: is there a link?
Authors: Flanagan Heather , Lin Chih-Jen , Campbell Lisa L , Horner Paddy , Horne Andrew W , Spears Norah
Published: December 2020

Ectopic pregnancy (EP) is defined as the implantation of an embryo outside of the uterus and is a leading cause of first trimester maternal mortality and morbidity. This article discusses a possible role for epithelial to mesenchymal transition in the pathogenesis of EP, given the notable similarity of protein expression between the two processes.
Mechanism of transformation of agricultural enterprises in terms of innovative development
Authors: Shelenko Diana , Balaniuk Ivan , Sas Liudmyla , Matkovskyi Petrо , Kozak-Balaniuk Iryna
Published: December 2020

The mechanism under study should be aimed at introducing innovative approaches to the modernization of technical l and technological cycles of production and economic processes, strengthening the competitive position of enterprises in the agrarian market and overcoming internal and external institutional barriers to enterprise development by suppressing irrational institutional influences on the functioning. The purpose of this study is to substantiate theoretical and methodological foundations and to develop applied approaches for implementing the mechanism of transformation of agricultural enterprises in a competitive environment. The scientific novelty of the obtained results lies in the substantiation of the mechanism of transformation of agricultural enterprises, which includes such components as: information and analytical tools (monitoring of the economic environment, verification and systematization of information data, establishment of essential laws and relationships, the formation of information bases of decision  making, management, design-testing apparatus (designing a perspective plan for the transformation of agricultural enterprises, pilot testing of the target project of the proposed changes in the organizational and legal form of management, adjustment of the project of transformation of enterprises) and implementation-block (formation of innovative structures of agricultural enterprises, ensuring the sequence and consistency of implementation of target changes, minimization of conflict environment in the process of transformation in balancing the duties, process responsibilities and responsibilities in terms of the structural components of the new organizational and legal system). The social and economic effect of this mechanism is achieved through a synergistic effect obtained through the functional interaction of enterprises that are able, however, to work autonomously. The practical significance of the mechanism is manifested in the ability to generate comprehensive management support in the process of transformation of agricultural enterprises, taking into account the specifics of a particular organizational and legal form of management in a competitive environment of their operation.
Financial behavior of united territorial communities in the conditions of decentralization reform in Ukraine
Authors: Melnyk Viktor , Shchur Roman , Tsiupa Oksana
Published: December 2020

The article deals with the study of amalgamated territorial communities functioning peculiarities during the decentralization in Ukraine. It contains substantiation of the territorial community’s financial behavior as a basis for efficient administrative and financial decisions, as well as a study of the character and model of this behavior. The research of the models and peculiarities of amalgamated territorial communities’ financial behavior allows assessment and forecast of their social and economic development vectors; establishing the grounds for subsidies and opportunities for the increase of financial solvency regarding the formation of their expenses and performance of functions and assignments, laid upon them. The results of the research have emphasized the need for further scientific studies of behavioral aspects of the amalgamated territorial communities’ financial resources forming, as well as substantiation of their financial decisions for the attraction of additional proceeds. Active implementation of decentralization reform in Ukraine has started only in 2014 with creation of amalgamated territorial communities. The authors have researched the essence of the amalgamated territorial community’s financial behavior, being the basis for the establishment of its financial solvency, sustainability, as well as social and economic development. The study found that the main factor influencing the financial behavior of amalgamated territorial communities in Ukraine in terms of the priority of their budget expenditures and investment activities is the size of the community (characterized by area and population). The authors also proved that the key motives for the financial behavior of amalgamated territorial communities in matters of priority of budget expenditures and investment activities are the following: increasing their own revenues and increasing the financial independence of local governments. This actualizes the search for their own ways to strengthen financial capacity and prepare attractive offers to investors and increase the number of jobs, as well as further unification of small local communities.
First Insights on Peruvian Luxury Consumers
Authors:   SémioConsult & ESSEC Business School, Larraufie Anne-Flore Maman
Published: December 2020

Peru is an emerging country showing strong potential for future luxury developments. It already holds luxury regular consumers, mainly in the Lima capital. However, it is currently approached in a standardized process by luxury firms, following what is done in other emerging markets for luxury. To be efficient, it is necessary to get more knowledge about Peruvian consumers. This is what this article aims at. After reviewing the historical background of the country along with its cultural dimensions, we present results from a two-stage analytic process based on data collected from secondary sources and interviews with consumers. We derive from that practical recommendations for luxury managers and propose some research questions and hypotheses to be further explored and tested.
Methodological Proposal Focused on the Intangible Resources Diagnosis of Intellectual Capital for Tourism Destination
Authors:   UNCo, Andrea Quadrini Fabiana , Anahi Abraham Cynthia
Published: December 2020

The purpose of this paper is to develop and deepen one of the research lines that since 2010 the research team has been working on. It is related to one of the objectives set forth in the schedule of the research project “Management of the intellectual capital and innovation for tourism destination: a way to boost sector competitiveness”, which is being developed. The aim is to design and present a method that let make a diagnosis of intangible resources of intellectual capital for tourism destination and show its positive relation with innovative activity.
Impacts of Environmental Regulation on Sustainable Economic Growth
Authors: Fisher Jonathan
Published: December 2020

There is considerable concern and debate about the economic impacts of environmental regulations. Jonathan Fisher, former Economics Manager at the Environment Agency in England and Wales, reviews the available evidence on this subject. Section 2 presents estimates of the costs and benefits of environmental regulations. Section 3 examines the impacts of environmental regulations on economic growth, innovation and technical change as well as impacts on competitiveness and any movement of businesses to less pollution havens. He questions call for greater certainty regarding future environmental regulations, whereas in fact there should be calls for less uncertainty. This section then suggests how this could be achieved. This section then finishes with an overview of the available evidence. This includes an examination of the Porter Hypothesis that environmental regulations can trigger greater innovation that may partially or more than fully offset the compliance costs. Section 4 then sets out principles for how better environmental regulation can improve its impacts on sustainable economic growth and illustrates how the European Union (EU) Water Framework Directive is a good example of the application of these principles in practice. Section 5 reviews current and recent political perspectives regarding developments in environmental regulations across the EU and shows how the United Kingdom (UK) has successfully positively managed to influence such developments so that EU environmental regulations now incorporate many of these principles to improve their impacts on economic growth. Section 5.1 then examines the implications of Brexit for UK environmental regulations. Finally, Section 6 sets out some best practice principles to improve the impacts of environmental regulation on sustainable economic growth, innovation and technical change.
The Measure of Emotional Intelligence in Leaders
Authors:   LeTourneau University, Clark Madison , Waldo Robert Douglas ,   Liberty University, Wharton Robert B.
Published: December 2020

A data group of 246 individuals was collected to explore the possible correlations between trait-based and competency-based Emotional Intelligence factors to determine how the development of characteristics can contribute to an individual’s influence potential — their “ReAch”. The study was also conducted to demonstrate how an increase in Emotional Intelligence can occur in aspiring and existing leaders to further the effectiveness and success of the individual and their work environment. The data pool was required to complete two surveys: the SSEIT, which measures trait-based Emotional Intelligence, and the LDP, which measures competency-based factors and the degree to which each trait existed in each individual. This paper explores the relationship between Emotional Intelligence and the traits that are naturally present and those that are a result of learning, development and environmental factors. We are seeking to address the objective of improving leadership abilities and to explore the needed tools to develop rising leaders. The correlations that we are exploring between these two sets of data points could help further present the possibilities of self-improvement in the workplace.
Contemporary Transformations in the Global Pharmaceuticals Industry and Strategic Imperatives for Bangladesh Enterprises
Authors:   University of Dhaka, Sadek Md. Abu Zafor , Anwar Syed Ferhat ,   University of Dhaka
Published: December 2020

Global pharmaceuticals industry is expected to reach $1.5 trillion by 2021 with a moderate growth of 4%-7% although it was almost 9% in the recent past (IMS, 2016). This changes in the regular growth projection is due to some basic transformation in this sector among which gradual reduction of blockbuster era, innovation crisis, requirement of high R&D investment, reduced health budget by many governments, emergence of biosimilars and traditional medicines, uneven price competition, drug approval stagnation, institutional buying, strict regulatory guidelines are important. Nevertheless, Bangladesh pharmaceuticals industry is now a promising global player with a domestic market size of $2 billion (BAPI, 2017). This sector is exporting medicines to 127 countries including USA, UK and other regulated countries with a global market capitalization of almost $ 82.11 million after meeting 98% of the local demands. The average growth in domestic and export markets are 15% and 24% respectively (The Daily Star, 2017 & BAPI, 2017). Although this industry seems to be very flourishing both in domestic and global market but it is highly dependent on other countries considering researches and technologies that would be major setbacks in the upcoming days. Therefore, this study illustrates the contemporary transforming in global pharmaceuticals industry & suggests some strategic imperatives for Bangladesh enterprises.
Integrated Management Applications in the Public Administration in Goiás
Authors:   Pontifical Catholic University of Goiás, Sodré Ezequiel Alves de Godoi , Reis Irene ,   Pontifical Catholic University of Goiás, Waqued Cárbio Almeida ,   Pontifical Catholic University of Goiás, Lima Tereza Cristina Pinheiro de ,   Pontifical Catholic University of Goiás, Nepomuceno Denise Lúcia Mateus Gomes ,   Pontifical Catholic University of Goiás
Published: December 2020

This study presents an organizational diagnosis of the Regional Electoral Court in Goiás by focusing on the Information Technology department. It aims to explain the advantages, disadvantages, facilities and difficulties to implement and execute integrated management applications in the structure of the Court. Methodologically, an exploratory and descriptive research was used along with qualitative analysis through semi-structured interviews with IT leaders. These researches provided a better comprehension of the theme by analyzing the actions related to the IT area with focus on innovation and Enterprise Resource Planning at a public agency. The study concludes that Enterprise Resource Planning applications are — even with the considerable disadvantages of development costs or acquisitions — one efficient and viable alternative, with the benefit of streamlining the use of physical, financial and human resources, providing a true revolution in operational and managerial activities through process economicity and optimization. The support given by senior management and the availability of sufficient resources and infrastructure make implementation easier, while the difficulties happen due to resistance to change by end users and cuts in public funding for the development of new systems.
Diagnóstico del pensamiento crítico de estudiantes de educación primaria de Chimbote, Perú
Authors: Pérez-Morán Graciela , Bazalar-Palacios Janina , Arhuis-Inca Wendy
Published: December 2020

Objective. To determine the level of development of the critical thinking of the students of the Educational Institutions of primary education of Chimbote. Materials and methods. A descriptive study was carried out in Chimbote, 2016. Critical thinking was evaluated in 250 boys and girls who belong to the sixth grade of primary education in 2016. A questionnaire of 30 questions aimed at addressing the dialogic and substantive dimensions was applied; each question included 5 response options on the Likert scale (1 = total disagreement up to 5 = total agreement). These variables were re-categorized by scaling by percentiles classified into three categories: (a) high, between 150-100 points; (b) medium, between 99-50; and (c) low, between 49-0 points. A descriptive analysis of the critical thinking variable was carried out according to its substantive and dialogic dimensions through tables with their relative and absolute frequencies. Results. There is a negative tendency in the development of critical thinking which is integrated the dimensions of substantive and dialogical, being the lowest level the one that obtained the highest percentage with 54% compared to the high level with 4.4%. Conclusion. There is a deficit of critical thinking in student body students and in for their substantive and dialogical dimensions.