bluuebunny/crossref_metadata_2025 huggingface dataset:
Low Viscosity Resin Penetration Degree in Incipient Caries Lesions
Authors: Sava Rosianu Ruxandra , Podariu Angela Codruta , Negrutiu Meda Lavinia , Szuhanek Camelia , Sinescu Cosmin
Published: February 2020

Resin infiltration is considered a treatment option for initial caries lesions. To prevent enamel lesion s from further demineralization a complete and homogeneous penetration of low-viscosity resins should be accomplished. The aim of this study was to compare the penetration abilities of 3 commercial products: Icon (DMG, Germany), Fluorodose (Centrix Inc. USA) and Tetric flow (IvoclarVivadent, Schaan, Liechtenstein).Artificial white spot lesions were produced in 60 orthodontic extracted human premolars. The samples were randomly divided into 3 groups: F - weeklyapplication of 5%fluoride gel; IC � resin infiltration (Icon1-DMG) and T - treatment with composite resins (Tetric flow). Specimens were studied using confocal microscopy and penetration depths were determined. A good correlation between PC and penetration depth was thereby observed (Pearson correlation coefficient, r=0.820).
Simulation of the Sucker Rod Column Dynamics for Different Pumping Regimes
Authors: Toma Georgeta , Pupazescu Alexandru , Badoiu Dorin
Published: February 2020

Proper functioning of the sucker rod pumping installations is strongly influenced by the sucker rod column dynamics and can be appreciated, as is well known and widely applied in practice, by the allure of the surface dynagraph. The paper presents some results concerning the simulation of the sucker rod column dynamics obtained with a computer program developed by the authors. The simulation results are compared with experimental results obtained at two pumping installations. Then, the computer program is used to study the sucker rod column dynamics for another pumping regime at one of analyzed installations.
Long Term Assessment of the Biological Profile in Patients with Acute Myocardial Infarction and Left Bundle Branch Block
Authors: Georgescu Catalina Arsenescu , Anghel Larisa
Published: February 2020

In order to study the impact of an acute coronary syndrome on the lifestyle changes of the patients, we prospectively studied the long term biological parameters of patients with myocardial infarction. After a median follow-up of 17 months, we noticed a significant improvement in the lipid profile of patients, both due to lifestyle changes and therapeutic compliance. Certainly, the occurrence of an acute coronary event has altered patients� attitudes about cardiovascular risk, motivating changing lifestyle and choosing the right therapy.
Modelling of Ethanol Fermentation Coupled with Product Recovery by Pervaporation
Authors: Trica Bogdan , Parvulescu Oana Cristina , Dobre Tanase , Janabi Ali A. A. Al , Raducanu Cristian , Patrichi Claudia
Published: February 2020

Bioethanol is the most important biofuel produced by fermentation of sugars from various biomass types. The main disadvantages associated to this process consist in the negative effect of high ethanol concentration on the cell growth and in the separation cost of ethanol-water system resulted in the fermentation process. Sugar fermentation using Saccharomyces cerevisiae yeast coupled with bioethanol recovery by pervaporation has been modeled and simulated in this paper. In order to avoid the clogging of pervaporation membrane, the yeast cells were previously retained into an ultrafiltration unit. Three operating modes were analyzed and compared, i.e., classical batch fermentation (BF), batch fermentation coupled with external ultrafiltration and pervaporation (BFPV), and fed batch fermentation coupled with external ultrafiltration and pervaporation (FBFPV). Surface areas of ultrafiltration and pervaporation units were selected as process control variables.
Polyphenols, Organic Acids and Antioxidant Activity in Unexplored Phemeranthus Confertiflorus L
Authors: Gatea Florentina , Teodor Eugenia Dumitra , Nagoda Eugenia , Radu Gabriel Lucian
Published: February 2020

Some aspects of the chemical composition were studied in extracts of unexplored Phemeranthus confertiflorus L, an alien plant collected from Bucharest delta. 16 polyphenols and 10 short-chain organic acids were analysed and quantified by capillary electrophoresis in Phemeranthus extracts and antioxidant activity was investigated. The results obtained could promote Phemeranthus as an eligible plant with potential in food industry and for human health, because of the high antioxidant activity, high content of flavonoids (naringenin, rutin, daidzin) and lactic acid.
Removal of Heavy Metals from Aquatic Environments Using Water Hyacinth and Water Lettuce
Authors: Radu Violeta Monica , Ionescu Petra , Diacu Elena , Ivanov Alexandru Anton
Published: February 2020

The quality of the aquatic environment was strongly influenced by the development of urbanization, industrialization and population growth, and therefore water pollution, mainly due to the presence of heavy metal, becoming a widespread concern. The objective of this work was to evaluate the possibility to remove heavy metals Cd, Zn, Cr and Ni from wastewater using two aquatic plants, water hyacinth (Eichornia crassipes) and water lettuce (Pistia stratiottes). These plants possess excellent abilities to metabolize and bioaccumulate heavy metals from various polluted aquatic environments. For a period of 30 days, the content of heavy metals from wastewater and aquatic plants samples was monitored weakly and the efficacy of these plants to remove heavy metals was quantified. Heavy metals were determined by atomic absorption spectrophotometry with graphite furnace (GFAAS). The obtained results have shown the efficacy of Eichornia crassipes and Pistia stratiottes to remove metals from the studied wastewater. The bioaccumulation rate of heavy metals in plants was effective until day 24 of the period of 30 days of the experiment, as the plants become inefficient beyond this period. The uptake of heavy metals in the studied aquatic plants depends on the concentration of each heavy metal present in the used wastewater and the exposure time.
Determining Water Vapour Phase Equilibrium Coefficients at Different Temperatures for Gas Wells
Authors: Dumitrache Liviu , Nistor Iulian , Suditu Silvian , Badea Ana Maria
Published: February 2020

In the course of gas production from reservoirs across the world, salt precipitation from the reservoir water is observed to an increasing extent as recovery progresses. This phenomenon, likewise, occurs during the injection of dry gas into porous aquifers. Salt deposits can form in the production string, in the perforation zone as well as in the area of the reservoir surrounding the well [1]. A better understanding of salt precipitation phenomena along with the conditions under which this takes place is needed for a better productivity control [2]. Simulating the process and taking actions as necessary may reduce or even eliminate the necessity for down-hole fresh water washes and, in turn, minimize the overall production losses. Input for this simulation are also the Water-Vapour Phase Equilibrium Coefficients. This article presents a methodology on how to obtain these coefficients for different temperatures using commercial simulators.
Collagen Hydrolysate as Sustainable Additive for Cereal Seed Treatment
Authors: Gaidau Carmen , Niculescu Mihaela Doina , Epure Doru Gabriel , Tudorache Madalina , Radu Elena , Stoica Rusandica , Ignat Madalina , Gidea Mihai
Published: February 2020

The paper presents new results on the application of collagen hydrolysates characterised in terms of molecular weight, polydispersity (GPC/ SEC), chemical composition and free amino acid composition (GC-MS) for the treatment of cereal seeds. Surface tension and contact angle determinations (VGA Optima XE) have highlighted an improvement in the hydrophilicity of collagen hydrolysates in pesticide mixtures as premises for the adherence of wheat seeds onto the surface. The identification of a 39% higher gibberellic acid concentration (RP-HPLC) in germinated seeds in the collagen hydrolysate, and the presence of free amino acids and low molecular weight fractions were correlated with the biofertilizing and biostimulating effects registered in field experiments on wheat crops.
Methods for the Quantification of Salivary Cortisol and of a-amylase in Biosensors and Portable Devices
Authors: Ghiciuc Cristina Mihaela , Szalontay Andreea Silvana , Radulescu Luminita , Cozma Sebastian , Lupusoru Catalina Elena , Saponaro Angelo , Ifteni Petru , Patacchioli Francesca Romana , Cozma Lucia Corina Dima
Published: February 2020

There is an increasing interest in the analysis of salivary biomarkers for medical practice. The objective of this article was to identify the specificity and sensitivity of quantification methods used in biosensors or portable devices for the determination of salivary cortisol and salivary a-amylase. There are no biosensors and portable devices for salivary amylase and cortisol that are used on a large scale in clinical studies. These devices would be useful in assessing more real-time psychological research in the future.
Interdisciplinary Therapeutic Approaches Based on the Relatioship Between Dental Pain Perception and NiTi Archwires Types, Evaluated in the First Months of Orthodontic Treatment
Authors: Macovei Georgiana , Beldiman Antonela Maria , Scutariu Mihaela Monica , Armencia Adina Oana , Surlari Zenovia , Tofan Nicoleta , Moldovan Antonia , Pancu Galina
Published: February 2020

Pain is one of the most common reasons for patients scheduling or avoiding appointments in the dental office. This symptomatology which is commonly associated with fixed orthodontic treatment, may have a negative impact on the quality of life of the patient and may cause absences from periodic appointments. Interdisciplinary orthodontic treatment has a clear positive effect on psychological, functional, social health but also involves pain and discomfort, at least in the early stages or until the adaptability of the body occurs. The use of NiTi archwires during the first stages of treatment provides the development of physiological forces, but depending on each patient pain threshold, dental pain is perceived.
Prolonging Nerve Grafts Using Chemical Extracted Muscle-in-vein with Vein Window Method Chemical acellular nerve grafts
Authors: Jemnoschi Hreniuc Irina Mihaela , Tamas Camelia , Pasca Sorin Aurelian , Ciuntu Bogdan , Ciuntu Roxana , D. Negru Robert , Zamfir Carmen , Stamate Teodor
Published: February 2020

Nerve injuries are a common pathology in hand trauma. The consequences are drastic both for patients and doctors/medical system. In many cases direct coaptation is impossible. A nerve graft should be used in the case of a neuroma, trauma or tumor, for restoration of nervous influx. The aim of this study is demonstrate that by grafting restant nerve stumps with muscle-in-vein nerve grafts we obtain good result in terms of functional and sensibility recovery and also our method �window-vein� is a good way of prolonging nerve grafts. The method of study is experimental. We worked in the laboratory in optimal conditions for carrying out of muscles-in-vein nerve grafts (nerve grafts size 1.5 cm-3 cm). We used acellular muscle grafts with the chemical extraction method.The study was conducted on experimental animals (Wistar male rats).We used 30 experience animals in 3 equal groups (classical group and muscle-in-vein nerve grafts-2 nerve grafts of 1,5 cm central sutured and the third group with muscle-in-vein nerve grafts, window-vein method, 3 cm). At 4 and respectively 6 weeks postoperative at the quality tests we observed the progress with the footprint test. The operated hind in comparison with the healthy hind was 86% recovered and similar with classic nerve grafts. Quantitatively the number of regenerated axons in the group with muscle-in-vein nerve grafts was significant bigger in comparison with the classical group (15%).The method using muscle-in-vein nerve graft with windows-vein it�s a good alternative for nerve grafting in comparison with classical nerve grafting. When the local possibilities are limited, this method is good for prolonging the grafts. The relationship between cost and benefit in this case it�s an advantage because we use the local resources of the affected area. The motor results of nerve grafting ingroup 2 in comparison with group 3 were similar and in some cases better in group 1. Grafting with MVNG offers a better alternative for donor site regeneration in comparison with classical nerve grafts. This method is useful to prolong nerve grafts without adding morbidity.
Solid Waste Management on Romanian Households
Authors: Ungureanu George , Ignat Gabriela , Leonte elena , Costuleanu Carmen Luiza , Stanciu Nicoleta , Sandu Ioan Gabriel , Donosa Dan , Bejinariu Costica
Published: February 2020

The problem associated with the household behavior on solid waste disposal site in today�s society is complex because of the large quantity and diverse nature of the wastes. Due increase the population, rapid development, global agricultural development has moved rapidly, limitations of financing, emerging limitations of both energy and raw materials and also add to the complexity of any waste management system, large quantities of wastes are being generated in different forms such as solid, liquid and gases. This research explored factors affecting the level of participation in solid waste segregation and recycling of households in Romania, as well as examining current Romania households waste management practices and their knowledge of waste management. This study investigated the solid waste situation and the organization of solid waste management in both urban and rural settings from the perspective of households. Solid waste management is a key component of public services which needs to serve the urban and rural municipalities in an efficient way in order to maintain a decent standard of public health.
Eco-friendly, Facile and Rapid Way for Synthesis of Selenium Nanoparticles Production, structural and morphological characterisation
Authors: Cavalu Simona , Kamel Earar , Laslo Vasile , Fritea Luminita , Costea Traian , Antoniac Iulian Vasile , Vasile Eugeniu , Antoniac Aurora , Semenescu Augustin , Mohan Aurel , Saceleanu Vicentiu , Vicas Simona
Published: February 2020

A green chemistry approach to synthesize biocompatible selenium nanoparticles is proposed in this work, using hydrogen selenite (NaHSeO3) as selenium precursor and lactose as reducing agent. The formation of nanoparticles was confirmed by dynamic light Scattering, revealing a gaussian size distribution, the maximum percentage being in the range of 20-40 nm. Zeta potential measurement indicates a negative charge -38.2 mV, the stability of selenium colloidal sol being also confirmed by UV-visible spectroscopy. TEM and AFM revealed the homogeneous, spherical shape, confirming the size of nanoparticles in the range of 20-40 nm. Structural investigations of powder selenium nanoparticles by FTIR spectroscopy and XRD patterns emphasise the presence of stretching and bending vibrations of Se-O bonds, respectively the amorphous structure of the synthesized selenium. The proposed method is suitable for biological applications such drug release, functional food or nutritional supplements.
Hydrogenation of Naphtalene on Pt-Pd Catalyst
Authors: Popescu (Stanica) Andra Ioana , Bombos Mihaela , Popovici Roxana Daniela , Bombos Dorin , Bolocan Ion
Published: February 2020

The hydrogenation of naphthalene was conducted on Pt-Pd /g-Al2O3 catalyst. Characterization of the catalyst was carried out by determination of acidity and textural characteristics. The distribution of the acid strength of the prepared catalysts was determined by thermic desorption of diethyl amine and textural characteristics were determined by desorption of liquid nitrogen. Experiments were carried out on 1.5-6h-1 and molar ratio hydrogen/ naphthalene of 10/1. The main compounds identified were tetralin, trans and cis-decalin. The naphthalene conversion was higher and grew up with temperature and pressure. Higher activity of Pt-Pd /g-Al2O3 catalyst is probably due to the appropriate distribution of textural and strength acid.
GC-MS, HPLC, TLC of Dorycnium herbaceum Tincture Species and Synergistic / Antagonist Effect Testing in Combination with Antibiotics
Authors: Varut Renata Maria , Rotaru Luciana Teodora
Published: February 2020

The study objectives were to determine the chemical composition and the synergistic / antagonistic effect of the association between hydroalcoholic extract from the Dorycnii pentaphylli herba (DPH) and the antibiotics of choice, on five reference strains. The tincture contains flavonoids and polyphenol carboxylic acids in low concentrations. DPH has an antagonistic effect on three of the drugs tested (amoxicillin + clavulanic acid, levofloxacin, amikacin), the therapeutic effect being completely canceled and has no significant effect on two of them (ceftazidime, cefotaxime).
Optimisation of the Oil Extraction from Nigella sativa Seeds Using Response Surface Methodology
Authors: Isopencu Gabriela , Marfa Mirela , Jipa Iuliana , Stroescu Marta , Guzun Anicuta Stoica , Chira Nicoleta , Popescu Mariana
Published: February 2020

Nigella sativa, also known as black cumin, an annual herbaceous plant growing especially in Mediterranean countries, has recently gained considerable interest not only for its use as spice and condiment but also for its healthy properties of the fixed and essential oil and its potential as a biofuel. Nigella sativa seeds fixed oil, due to its high content in linoleic acid followed by oleic and palmitic acid, could be beneficial to human health. The objective of this study is to determine the optimum conditions for the solvent extraction of Nigella sativa seeds fixed oil using a three-level, three-factor Box-Behnken design (BBD) under response surface methodology (RSM). The obtained experimental data, fitted by a second-order polynomial equation were analysed by Pareto analysis of variance (ANOVA). From a total of 10 coefficients of the statistical model only 5 are important. The obtained experimental values agreed with the predicted ones.
Correlation Between Recombinant Human Erythropoietin Dose and Inflammatory Status in Dialysed Patients
Authors: Niculae Andrei , David Cristiana , Dragomirescu Razvan Florin Ion , Peride Ileana , Turcu Flavia Liliana , Petcu Lucian Cristian , Covic Adrian , Checherita Ionel Alexandru
Published: February 2020

Once recombinant human erythropoietin (r-HuEPO) was introduced in daily practice, huge steps were made in combating the adverse effects induced by anemia in chronic kidney disease population. Still, r-HuEPO resistance and the doses ensuring the maximum therapeutic benefit remain matters of debate. The aim of our study was to assess the correlation between the presence and the degree of inflammation and the r-HuEPO requirements in chronic dialysis patients. We conducted a 2 years prospective study on 146 patients undergoing chronic dialysis treated with r-HuEPO. Based on their average CRP (C-reactive protein) levels, obtained from repeated samplings at 3 months interval, 3 groups were formed; we noted in each group the average values of r-HuEPO prescribed to achieve the optimum hemoglobin levels according to the dialysis best practice guidelines and all the adverse effects of the therapy. A direct correlation was observed between CRP levels and r-HuEPO requirements in the first 2 groups of patients (CRP under 6 mg/L and CRP values 6-20 mg/L), with significant increase in r-HuEPO doses between groups (p [ 0.001); the third group, CRP values over 20 mg/dL, showed a minor, insignificant increase in average r-HuEPO doses compared to mild inflammation group (p = 0.199) and more adverse effects of the therapy (p [ 0.05). Inflammation is an important determinant of anemia in chronic dialysis patients and can induce an increase in the doses of r-HuEPO. However, prescribing excessive r-HuEPO doses is not the answer in severe inflammatory status, due to lack of response and possible adverse effects.
Influence of Enzymatic Cocktails on Conversion of Agricultural Lignocellulose to Fermentable Sugars
Authors: Vintila Teodor , Gherman Vasile Daniel , Popa Nicolae , Popescu Dumitru , Buzatu Carmen , Motoc Marilena
Published: February 2020

Agricultural lignocellulosic biomass is regarded as an important source of biofuels, especially bioethanol and biohydrogen. The following aspects have been studied: the effect of type of substrate used in production of cellulolytic enzymes, the activity of several enzymatic cocktails used to hydrolyse three types of agricultural biomass and the influence of provenience of enzymatic cocktails on sugars yields in the hydrolysis process. Fungi investigated in this study (T. longibrachiatum DSM 769) release higher titter of enzymes when raw, unpretreated agriculture residual biomass is used as substrate and inducer for biosynthesis of cellulolytic enzymes. Cellulolytic enzymes produced in culture media containing a certain type of agricultural lignocellulosic biomass as substrate, can be used in hydrolysis of other types of agricultural lignocellulosic biomass with similar sugar yields. Cellulases produced in culture media containing purified crystalline cellulose as substrate does not contain all necessary types of enzymes to hydrolyze lignocellulosic complex from agricultural biomass to produce high yields of sugars. On-site production of cellulases can be an effective approach biorefinery of lignocellulose to produce biofuels or other biochemicals by fermentation.
Fuels Desulphurisation by Adsorbtion on Fe / Bentonite
Authors: Ion Constantin Sorin , Bombos Mihaela , Vasilievici Gabriel , Bombos Dorin
Published: February 2020

Desulfurisation of atmospheric distillation gasoline and gas oil was performed by adsorption process on Fe/ bentonite. The adsorbent was characterized by determining the adsorption isotherms, specific surface area, pore volume and average pore diameter. Adsorption experiments of atmospheric distillation gasoline and gas oil were performed in continuous system at 280�320oC, 5 atm and volume hourly space velocities of 1�2 h-1. The efficiency of adsorption on Fe / bentonite was better at desulphurisation of gasoline versus gas oil.
Circulating Chemerin is Associated with Subclinical Atherosclerosis in Obesity
Authors: Aursulesei Viviana , Anisie Ecaterina , Alecsa Ana Maria , Leon Constantin Maria Magdalena , Namat Razan Al
Published: February 2020

Chemerin is a newly discovered adipokine with controversial role in obesity. The relationship between circulating chemerin and noninvasive biomarkers of subclinical atherosclerosis is far from being elucidated. Our study concluded that chemerin could be an independent predictor for arterial stiffness, but not for mean carotidian intima media thickness and epicardial fat thickness. Most probably, the effects of chemerin are modulated by concurrent metabolic factors and mechanisms involved in early atherosclerosis.
Effect of Temperature and Heating Rate on the Char Yield in Sorghum and Straw Slow Pyrolysis
Authors: Filipovici Alexandru , Tucu Dumitru , Bialowiec Andrzej , Bukowski Przemyslaw , Crisan George Catalin , Lica Septimiu , Pulka Jakub , Dyjakon Arkadiusz , Debowski Marcin
Published: February 2020

Different approach to valorise the sweet sorghum using pyrolysis process to obtain valuable resources for energy production: bio-char, bio-oil and syngas are presented in the paper. In this study the influence of process parameters of slow pyrolysis on sorghum and straw were analysed. Temperatures used in the process varied from 400 to 800�C and heating rate parameter varied from 10�C . min-1 to 65�C . min-1. The experiments were conducted using a lab scale slow pyrolysis reactor with electric heaters, equipped with a thermo balance analyzer to collect data of pyrolysis process. The achieved product yield can vary significantly according to the slow pyrolysis parameters. The temperature influenced more on the bio-char yield compared to the heating rate parameter. The highest bio-char yield (over 35% weight,) was obtained at 400�C and heating rate of 10�C . min-1.
Biological Features of Tumors Results of Experimental Studies
Authors: Grigore Ana Camelia , Busila Camelia , Chesaru Ioana Bianca , Calin Alina , Pavel Liliana Lacramioara
Published: February 2020

Tumor anaplasia can be of varying degrees, being especially marked in fast-growing malignant tumors. Blastomatose tissue is characterized by morphological, chemical, physico-chemical and energetic anaplasia. Structural changes of the tissue specific to blastomatose growth often provide the opportunity to differentiate this tissue from a normal or any other growing tissue. Out of various factors that may influence the external environment of tumors, we should mention food, profession, living and working conditions. Tumors and especially malignant tumors are accompanied by changes in the entire body. These are not just a consequence of the blastomatose growth but also play a role in its subsequent development. Experimental tumors are one of the methods of studying the issue of blastomatose growth. The tumor transplantation method is widespread and extensively applied in laboratory practice. It uses standard strains of tumors (rats, mice, etc.). The simplicity of the tumor transplantation method, which consists of the inoculation under the skin of animals of tumor fragments using a trocar or of the injection of a tumor emulsion under aseptic conditions, enables researchers to maintain the purity of the strain for a long time. Various views have been formulated at different times on the origin of tumor growth in accordance with the level of knowledge on this issue.
Particularities of Statin Therapy in Diabetic Patients
Authors: Pelin Ana Maria , Gavat Cristian Catalin , Balan Gabriela , Popescu Eugenia , Georgescu Costinela Valerica
Published: February 2020

The purpose of conducted study was to determine which of the different types of statins ensure a better control of biological markers in diabetic patients and which of the lipid molecules studied, could be a first choice of lipid-lowering therapy in people suffering from diabetes. The measurement of blood glucose levels depending on type of statin used, was another target of this research. Dyslipidaemia was a major risk factor for cardiovascular complications in people with diabetes. It was found that atorvastatin was the most effective statin in controlling dyslipidemia in diabetic, because has ensured optimum control of HDL, LDL - cholesterol, triglycerides and glycemic values, effect which was resulted from the particular chemical structure of atorvastatin. Atorvastatin was discovered to be the best predictor in diabetes mellitus type 2 treatment, with a sensitivity about 78% and specificity to 45%., the most highest values compared to Rosuvastatin and Simvastatin. Area Under the Curve (AUC = 0.610; AUC ]0.600).
Brave New Hope for Breast Cancer Aminopyrazole derivates between rational design and clinical efficacy
Authors: Nitulescu George Mihai , Iancu George , Nitulescu Georgiana , Iancu Raluca Claudia , Bogdanici Camelia , Vasile Danut
Published: February 2020

Breast cancer research is a priority nowadays because of the high burden the disease represents for health systems worldwide. New agents are intensively researched to overcome breast cancer biology. Our aminopyrazole derivatives showed promising results when tested in vitro on breast cancer cell lines, by inhibiting protein kinase pathways. Anti-proliferative effect of pyrazole compounds on different breast cancer cell lines was heterogeneous. Further research is necessary to design the optimal structure in terms of high antitumor efficacy and good safety profile. Ophthalmologist control is very important for patients with breast cancer because treatment with some drugs reported side ocular effects: cataract, maculopathy (crystals or drusen or yellowish spots), retinal hemorrhages or dry.
Characterization of Urban Atmospheric PM2.5 by ATR-FTIR, ICP-MS and SEM-EDS Techniques
Authors: Radulescu Cristiana , Stihi Claudia , Iordache Stefania , Dunea Daniel , Dulama Ioana Daniela
Published: February 2020

The study aims to investigate the chemical composition of airborne particulate matter with size below 2.5 �m (PM2.5) collected from Targoviste City area, in the summer of 2015. For this consideration eleven representative points have been chosen for sampling. This research provides interesting data which can clarify the relationship between PM2.5 exposure and the negative effects on human health at urban area level. Three analytical techniques have been developed for the qualitative, quantitative and morphological characterization of PM2.5. The inorganic and organic functional groups of the PM2.5 samples were investigated by Attenuated Total Reflectance - Fourier Transform Infrared Spectrometry (ATR-FTIR). The content of several elements (i.e. Pb, Cd, Cr, Ni, Cu, Mn, Al, Zn and Fe) in samples was determined by Inductively Coupled Plasma - Mass Spectrometry (ICP-MS). The measured concentration of these metals was compared with values reported by the International Agency on urban area in order to establish the minimal element level which cannot be considered as a potential health risk for the urban population. The morphological characterization of PM2.5 was performed by Scanning Electron Microscopy - Energy Dispersive Spectrometry (SEM-EDS). The elemental analysis of samples were performed by EDS and showed that airborne particle was mainly composed of elements, such as C, O, Si, Ca, N and S.
The Role of Clindamycin Phosphate Associated with Adapalene in Three Semisolid Formulations Developed for Topical Acne Treatment
Authors: Hussein Stela Mariana Al , Todoran Nicoleta , Imre Silvia , Hussein Hussam Al , Zaera Ana Melero , Hussein Hamida Al , Dogaru Maria Titica
Published: February 2020

Despite the fact that in mild-to moderate acne vulgaris the standard first-line therapy is the topical treatment with fixed combinations of antimicrobial agents and retinoids, the skin type and the skin barrier function should be taken into account when formulating a topical product. The aim of this study was the comparison of three new semisolid formulations developed for topical application by evaluation of their rheological behavior, as well as the evaluation of in vitro percutaneous diffusion through human epidermis membrane of the pharmaceutical ingredients. Clindamycin phosphate and adapalene were incorporated in three different topical bases, an HPLC method for the determination of their content in the new formulations being developed and validated. A higher concentration of drugs was released from the two gel systems (hydroxypropylmethylcellulose 2.5% -F1 and hydroxyethylcellulose 3% -F2) than from the oil-in-water cream (F3) at pH 7.4, whereas at pH 5.5 the drugs were released in higher amounts from the formulation F3. Following the rheological behavoir associated with the penetrability through the human epidermis membrane, our study results suggest that F1 and F2 could be appropriate in treating acne lesions in patients with oily skin and unaffected skin barrier function. In contrast, the oil-in-water cream (F3), due to its possible emolient effect and its higher penetrability at pH 5.5 than gel vehicles, may be indicated for patients with dry and sensitive skin associated with an altered skin barrier.
Research Regarding Content in Amino-acids and Biological Value of Proteins from Polyodon spathula Sturgeon Meat
Authors: Simeanu Cristina , Simeanu Daniel , Popa Anca , Usturoi Alexandru , Bodescu Dan , Dolis Marius Gheorghe
Published: February 2020

Polyodon spathula sturgeon breed is successfully reared in Romania in many fishery farms for meat production and it is capitalized on domestic market as consumption fish. In the current paper were studied a number of 1400 sturgeons from Polyodon spathula breed (1200 individuals of one summer - P.s.0+ and 200 individuals of fourth summers - P.s.3+). From this flock were weighted around 10%, for each age group, and for laboratory determinations were chosen 10 fishes for each age with the corporal mass close to the group mean. After analysing the fillets gathered from the studied fishes for establishing the chemical characteristics, nutritive and biological values of proteins were drawn some interesting conclusions. So, regarding chemical composition we notice that in the meat of analysed fishes water is in a rate of 75.41% at P.s.3+ and 78.37% for P.s.0+; proteins - between 18.08% for P.s.0+ and 19.89% for P.s.3+, values which place those fishes in the group of protein fishes; lipids - between 2.45% and 3.45%, values which situated those sturgeons in category of fishes with a low content in lipids; collagen � 3.83% at P.s.0+ and 4.14% at P.s.3+ which indicate low values for proteins of weak quality in the meat of those sturgeons. Study of nutritive value for the analysed fishes indicate the fact that fishes P.s.0+ have a mediocre nutritive value, having the ratio w/p of 4.33 while sturgeons P.s.3+ were placed in the 2nd category � fishes with a good nutritive value (rate w/p = 3.79). Energetic value of the studied fillets was 97.39 kcal/100 g for P.s.0+ and 114.31 kcal/100 g for P.s.3+, which enlightened an increase of nutritive value with aging, fact especially due to accumulation of adipose tissue. Study of proteins quality, through the presence of those 8 essential amino-acids in the meat of analysed fishes, show the fact that at sturgeons P.s.0+ proportion of essential amino-acids was 20.88% from total amino-acids, while at sturgeons P.s.3+ was 26.23%, fact which enlightened an increasing of proteins� biological value with fish aging. This fact was also shown by calculation of proteins� biological value through chemical methods (EAA index); calculated value for sturgeons P.s.0+ was a little bit lower (118.73) than the one calculated for sturgeons P.s.3+ (118.79).
Changes in the Chemical Composition of Blood
Authors: Berbece Sorin Ioan , Plesea Condratovici Alina , Pavel Liliana Lacramioara , Grigore Ana Camelia
Published: February 2020

The chemical composition of blood varies within rather narrow limit values. Relative constancy is more marked when certain components are concerned and less manifest when others are involved. Thus, mineral components allow narrower quantitative variation limits than organic substances concentration, more precisely than extractive substances, which may vary between wider limits. The variations of the formed elements/plasma ratio, which are common in pathological states, hinder the study of the chemical composition of blood, due to the fact that these oscillations are reflected in the overall chemical composition of blood. In most cases, chemical research needs to be conducted on blood serum and plasma, as they are more constant in their composition.
The Influence of Loads Superposition, Deterioration Due to Cracks and Residual Stresses on the Strength of Tubular Junction
Authors: Jinescu Valeriu V. , Chelu Angela , Zecheru Gheorghe , Pupazescu Alexandru , Sima Teodor , Draghici Gheorghe
Published: February 2020

In the paper the interaction of several loads like pressure, axial force, bending moment and torsional moment are analyzed, taking into account the deterioration due to cracks and the influence of residual stresses. A nonlinear, power law, of structure material is considered. General relationships for total participation of specific energies introduced in the structure by the loads, as well as for the critical participation have been proposed. On these bases: - a new strength calculation methods was developed; � strength of tubular cracked structures and of cracked tubular junction subjected to combined loading and strength were analyzed. Relationships for critical state have been proposed, based on dimensionless variables. These theoretical results fit with experimental date reported in literature. On the other side stress concentration coefficients were defined. Our one experiments onto a model of a pipe with two opposite nozzles have been achieved. Near one of the nozzles is a crack on the run pipe. Trough the experiments the state of stress have been obtained near the tubular junction, near the tip of the crack and far from the stress concentration points. On this basis the stress concentration coefficients were calculated.
The Evaluation of Biochemical and Microbiological Parameters in the Diagnosis of Emphysematous Pyelonephritis
Authors: Grigore Nicolae , Pirvut Valentin , Totan Maria , Bratu Dan , Cernusca Mitariu Sebastian Ioan , Cernusca Mitariu Mihaela , Chicea Radu , Sava Mihai , Hasegan Adrian
Published: February 2020

Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection of the renal parenchyma, produced by gas-forming Gram-negative bacilli. Even though only few cases are reported in the literature, the disease is not so rare and can become life-threatening if the diagnose is not quick and the therapeutic messures efficient. The biochemical analysis are the first line diagnostic, indicating the severity of the infection. The aim of our study was to to evaluate the importance of biochemical parameters, as first line diagnosis and also of the microbiological parameters, as etiologic diagnosis, in severe renal infections produced by gas forming bacili mainly in diabetic patients, predominantly women, with obstructive nephrolithiasis.
Fibrous Polymers in Textile Prospect for Tissue Engineering Development
Authors: Radu Cezar Doru , Danila Angela , Sandu Ion , Muresan Ioan Emil , Sandu Ioan Gabriel , Branisteanu Elena Daciana
Published: February 2020

Tissue engineering as an interdisciplinary field implies fibrous polymers as extracellular matrix as biologic support. The paper is a review on basic lines of the answer of textiles items at the biologic complex action. One carries out the evolution usage of the following polysaccharide supports: cellulose, gellan, pullulan, chitosan, hyaluronic acid, as well the collagen as a protein representative for a potential usage in an extracellular matrix. One presents the advantages and drawbacks adjusted to an online system and to new procedures available to develop a biologic structure on a textile support according with the main achievements reported in the literature of last years.
The Chemistry Decomposition in Human Corpses
Authors: Ioan Beatrice Gabriela , Manea Cristiana , Hanganu Bianca , Statescu Laura , Gheuca Solovastru Laura , Manoilescu Irina
Published: February 2020

Human body is a complex of organic substances (proteins, lipids, carbohydrates), which undergo chemical decomposition processes soon after death. The compounds released during decomposition characterize the development of different stages of this process: e.g. biogenic amines resulted from the proteins decomposition will confer the particular smell of a cadaver, gases resulted from carbohydrates fermentation will give the bloating aspect of the cadaver. The study of cadaver decomposition and the products resulted from this process is the subject of human taphonomy and is realized nowadays in special facilities in USA and Australia. Identification and analysis of the chemical compounds emerged after human decomposition (gases, liquids, salts) give valuable information to forensic pathologists for estimating the postmortem interval (PMI). More, volatile compounds � which give the odor signature�specific to human remains � may be utilized in identifying clandestine burials, human remains or victims entrapped under ruins in cases of natural disasters. In this paper the authors describe the chemical decomposition stages of human cadavers, the factors influencing these processes and utility for the forensic activity of the results of human taphonomic studies.
Scavenging Activity of Grapefruit Peel and Seed Extract, a Natural Source of Antioxidant for the Stabilization of Soybean and Sunflower Oil
Authors: Rasheed Sonia , Imran Muhammad , Rehman Summia , Farooq Amna , Begum Imtiaz , Kanwal Farah , Mitu Liviu
Published: February 2020

Grapefruit is source of anticancer and antioxidant reagents. Extracts of grapefruit peel (Gf-P) and seeds (Gf-S) were screened for their antioxidant capabilities at room temperature to stabilize soybean and sunflower oil for a storage period of 45 days. b-carotene linoleic acid system, FRAP assay, ABTS method were performed for the measurement of antioxidant potential of Gf-P and Gf-S. Oil samples containing extracts of Gf-P and Gf-S at 400 ppm, 800 ppm, 1200 ppm concentrations as well as synthetic antioxidants (BHT and BHA) at 200 ppm concentration were prepared. Free fatty acid (%) and peroxide (meq/Kg) values of all these prepared samples were evaluated. Results were statistically analyzed and it was observed that Gf-P has better antioxidant potential than Gf-S.
Chemical Interactions among Some Antimicrobial Solutions and Chelating Agents Used in Endodontics for Irrigation of Infected Root Canals
Authors: Lisa Elena Lacramioara , Carac Geta , Lupu Irina Teodora , Iliescu Andrei , Iliescu Alexandru Andrei
Published: February 2020

The root canal irrigants are of utmost importance in the soft tissue dissolving, the removal of microorganisms, hard-tissue debris, and smear layer. This study sets forth to investigate the stability and synergic interactions of different systems with various combinations among antimicrobial substances and chelating agents, frequently used in endodontics for the irrigation of the infected root canals through electrochemical evaluation, physicochemical and spectrophotometric analysis. The pharmaceutical products indicated as the antiseptic solutions (sodium hypochlorite - NaOCl, chlorhexidine - CHX) and chelating agents (EDTA, citric acid - CA) have large pH variations on the entire pH domain. The physicochemical parameters� (pH, conductivity) assessment at the CHX and CA solutions shown good stability in time and also electrochemical behaviour (OCP, CV). There is a dissociation of ions in aqueous medium and a competition of the chemical balances among the structures, as an intense electrochemical activity between the functional groups through the intensification of the anodic current currents, and a shift of the potential registered. This allows the formulation that chemical interactions are not always possible among diverse types of antimicrobial solutions and chelating agents for endodontic use.
Study of Electrolyte Serum Disturbances and Acid-base Status in Patients with Oral-maxillofacial and Dental Sepsis
Authors: Carausu Elena Mihaela , Trandafir Violeta , Ghibu Laura , Stamatin Ovidiu , Checherita Laura Elisabeta
Published: February 2020

Septicaemia is an important public health issue and a clinical challenge with a major impact on healthcare expenditure and resources. The present retrospective study was conducted over 127 patients registered during 2006-2015 for the area of Moldavia, Romania. In our study we are concerned about the serum electrolyte disturbances and acid-base status in patients with oral-maxillofacial and dental septicaemia. We measured serum levels of sodium, potassium, chloride, alkali reserve and pH. The prevalence of electrolyte disturbances was: 15.85% for sodium, 69.15% for potassium and 55.50% for chloride. Early recognition of acid-base status and serum electrolytes disturbances proves to be of great importance for clinical management since it signalizes the gravity of the disease and the increase of fatality rate, and is imperative to save the lives of patients with dental and oral-maxillofacial septicaemia.
Genetic Testing in Differentiated Thyroid Carcinoma � Important or Not?
Authors: Buruiana Andra , Dumitru Nicoleta , Ghemigian Adina , Nedeltcheva Petrova Eugenia
Published: February 2020

Thyroid carcinoma is the most common endocrine cancer representing 1-1.5% of all cancers diagnosed annually. Differentiated thyroid carcinoma (DTC) with the 2 main subtypes, papillary (PTC) and follicular (FTC), is the most common. DTC incidence has increased significantly in recent years, mainly due to increased and early use of imaging techniques (thyroid ultrasonography) and fine needle biopsy of thyroid nodules. Although after radical treatment, DTC is considered to be curable, histologic and clinical presentation is very diverse, the recurrence rate being 10-30%, while 5% of patients are resistant to conventional therapy, and some are even incurable. In recent years, there has been progress in terms of describing genetic changes in thyroid carcinoma, genetic testing providing important information that may influence therapeutic decision. The practical importance of these genetic mutations (for example, BRAF V600E, RAS, etc.) and their roles in tumorigenesis, the clinical features, treatment and prognosis of thyroid carcinoma is still controversial and incompletely elucidated.The increase knowledge of molecular pathogenesis and tumorigenesis in thyroid cancer lead to the emergence of new therapies with targeted antitumor effect and minimal toxicity. Patient selection should be made taking into account the risk stratification and tangible benefits, molecular tests being expensive and inaccessible.
Effect of the Sandblasting Process on the Surface Properties of Dental Zirconia
Authors: Earar Kamel , Grigoroiu Raluca , Scutariu Mihaela Monica , Vasile Eugeniu , Antoniac Aurora , Dragomir Lavinia , Gradinaru Sebastian
Published: February 2020

This paper presents the effect of the sandblasting and sintering processes on the surface properties of some commercial yttria stabilized zirconia (Y-TZP) for monolithic dental restorations in dentistry. The surface properties of dental zirconia can be improved further through various surface treatment methods, like surface abrasion, roughening, chemical treatment, tribochemical coating, or selective infiltration etching. But all these treatments are made on the sintered samples, not on the pre-sintered discs as are delivered by the dental suppliers. The hypothesis of this paper was that the mechanical effect on the surface of pre-sintered disc of Y-TZP assured by airborne-particle abrasion with alumina will be maintained after the sintering process. Additionally, we will follow the presence of alumina particles on the Y-TZP surface after airborne-particle abrasion process. Surface modifications of the experimental samples was performed by sandblasting for 15 s with Al2O3 particles (average particle size 83 mm) at pressure of 2 bars, using a SAB-Caloris equipment. Morphological and surface changes in the sandblasted, respectively sandblasted and sintered samples of Y-TZP are examined by using scanning electron microscopy, energy dispersive spectroscopy, and X-ray diffraction. It is found that the surface modifications made on the pre-sintered Y-TZP disc remain after sintering process, which not affects these mechanical modifications of the surface.
Also, it was detected the presence of alumina particles on the Y-TZP samples after airborne-particle abrasion process and for this reason we recommend the use of zirconia particle for airborne-abrasion process.
Levodopa as Treatment for Adults with Amblyopia
Authors: Bogdanici Camelia , Bogdanici Tudor , Moraru Andreea , Costin Danut , Feraru Crenguta
Published: February 2020

Levodopa is a medication used in treatment for Parkinson�s disease, which is associated with low levels of a chemical called dopamine in the brain. Levodopa is turned into dopamine in the body and therefore increases levels of this chemical. Levodopa was used as a treatment of amblyopia alone or in combination with classical treatment of occlusion. Visual acuity is improved after treatment with oral Levodopa. When is used as an adjunct to the occlusion therapy, Levodopa can be associated with long-term improvement in the vision, and may have also better compliance for patching. Levodopa stimulates the brain plasticity in adult age and can be used in treatment for amblyopia. Patients have also an increase of the visual acuity after orthoptic treatment for amblyopia and when Levodopa is administered, the vision increases much more. Contrary to the classical conception, according to which amblyopia cannot be treated after 10-12 years of age and it is untreatable in adults, studies about treatment with Levodopa in amblyopic eyes, may allow the improvement of the visual acuity in adults, as well.