bluuebunny/crossref_metadata_2025 huggingface dataset:
Promoting civility in nursing education and practice: A systematic literature review
Authors: Hanggamara Juneivent Saputra Datu , Felinia Leny , Witak Putry Sisilia , Eka Ni Gusti Ayu , Zega Windy Sapta Handayani
Published: May 2023

Background: Civility is an attitude of mutual respect and tolerance for differences that influences the professionalism of a nurse. However, there is a rise in incivility in nursing, including aggressive behavior, a lack of discipline, and failure to follow rules. Nursing education and practice are critical for promoting civil behavior through effective communication, conflict management, and resolution.Purpose: To determine strategies for promoting civility in nursing education and practice.Method: This study utilized a simplified approach to conduct a systematic review of the literature. The databases used were PubMed, Google Scholar, Science Direct (Elsevier), and EBSCO. Civility, incivility, promoting civility, and nursing were used as keywords.Results: This study identified two major themes: "strategy for promoting civility" and "impact of promoting civility." Active discussion, Problem-Based Learning (PBL), Civility Journal Club (CJC), role modeling, and self-reflection were all used to increase civility. The strategy's impact was measured in terms of individual capacity and interpersonal interaction.Conclusion: It is critical to promote civility in nursing education and practice. Nursing educators must facilitate activities that promote polite behavior, and nursing practice institutions must assist nurses in developing civility through civility promotion activities. Additional research can be conducted to ascertain the efficacy of civility promotion strategies in nursing as a means of promoting polite behavior.
Safety and efficacy of zinpentraxin alfa as monotherapy or in combination with ruxolitinib in myelofibrosis: stage I of a phase II trial
Authors: Verstovsek Srdan , Foltz Lynda , Gupta Vikas , Hasserjian Robert , Manshouri Taghi , Mascarenhas John , Mesa Ruben , Pozdnyakova Olga , Ritchie Ellen , Veletic Ivo , Gamel Katia , Hamidi Habib , Han Lyrialle , Higgins Brian , Trunzer Kerstin , Uguen Marianne , Wang Dao , El-Galaly Tarec Christoffer , Todorov Boyan , Gotlib Jason
Published: May 2023

Pentraxin 2 (PTX-2; serum amyloid P component), a circulating endogenous regulator of the inflammatory response to tissue injury and fibrosis, is reduced in patients with myelofibrosis (MF). Zinpentraxin alfa (RO7490677, PRM-151) is a recombinant form of PTX-2 that has shown preclinical antifibrotic activity and no dose-limiting toxicities in phase I trials. We report results from stage 1 of a phase II trial of zinpentraxin alfa in patients with intermediate-1/2 or high-risk MF. Patients (n=27) received intravenous zinpentraxin α weekly (QW) or every 4 weeks (Q4W), as monotherapy or an additional therapy for patients on stable-dose ruxolitinib. The primary endpoint was overall response rate (ORR; investigatorassessed) adapted from International Working Group-Myeloproliferative Neoplasms Research and Treatment criteria. Secondary endpoints included modified Myeloproliferative Neoplasm-Symptom Assessment Form Total Symptom Score (MPN-SAF TSS) change, bone marrow (BM) MF grade reduction, pharmacokinetics, and safety. ORR at week 24 was 33% (n=9/27) and varied across individual cohorts (QW: 38% [3/8]; Q4W: 14% [1/7]; QW+ruxolitinib: 33% [2/6]; Q4W+ruxolitinib: 50% [3/6]). Five of 18 evaluable patients (28%) experienced a ≥50% reduction in MPN-SAF TSS, and six of 17 evaluable patients (35%) had a ≥1 grade improvement from baseline in BM fibrosis at week 24. Most treatment-emergent adverse events (AE) were grade 1–2, most commonly fatigue. Among others, anemia and thrombocytopenia were infrequent (n=3 and n=1, respectively). Treatment-related serious AE occurred in four patients (15%). Overall, zinpentraxin alfa showed evidence of clinical activity and tolerable safety as monotherapy and in combination with ruxolitinib in this open-label, non-randomized trial (clinicaltrials gov. Identifier: NCT01981850).
The influence of genotype and year conditions on the transgressive variability of stem length in popu-lations of the second generation of soft winter wheat
Authors: Lozinskiy M. , Ustinova H. , Fedoruk Yu.
Published: May 2023

In 2019–2020, in the conditions of the experimental field of the Bila Tserkva National Agrarian University, populations of F2 hybrids, created by crossing soft winter wheat varieties that differ in the duration of the growing season, were studied. The aim of the work was to establish the degree and frequency of transgressions in the length of the main stem depending on the meteorological conditions of the year and the parental forms selected for hybridization, and to select selectively valuable recombinants for further research.
In 2019, in 40 out of 42 F2 populations, only a positive degree of transgression was established in terms of the length of the main stem, from 2.5 % (Myronivsk early/Kolchuga) to 53.8 % (Zolotokolosa/Shchedra nyva). With the use of maternal cytoplasm of early ripening varieties in four populations, all plants exceeded the extreme maximum values of the parents, and with the hybridization of mid-early, mid-ripening, mid-late varieties, 13 such combinations were studied.
In the conditions of 2020, positive transgressive recombinants were isolated only in six out of 20 populations based on hybridization with the maternal form of early-ripening varieties, and negative ones – in nine. Negative transgressive recombinants were selected in 13 of 21 populations created by crossing mid-early, mid-maturing, mid-late varieties. At the same time, no positive transgressions were found.
The selection of parental pairs differing in precociousness before hybridization expands morphogenesis in F2 populations of soft winter wheat and promotes the selection of both positive and negative transgressive recombinants by the length of the main stem. A significant influence of meteorological conditions and initial forms of hybridization on the formation of stem length and the manifestation of extreme maximum and minimum values in populations of the second generation of soft winter wheat was established.
The use of early-ripening cytoplasm in hybridization has a greater effect on the positive transgressive variability of the length of the main stem in F2 populations compared to medium-early, medium-maturing and medium-late maternal forms.
Key words: degree and frequency of transgressions, soft winter wheat, maturity groups, parent forms, main stem length, F2 populations.
New Environmentally Friendly Corrosion Inhibitor and its Properties
Authors:   Ryazan State Agrotechnological University named after P.A.Kostychev, Shemyakin A.V. , Fadeev I.V. ,   I.Ya. Yakovlev Chuvash State Pedagogical University, Uspenskiy I.A. ,   Ryazan State Agrotechnological University named after P.A.Kostychev, Rembalovich G.K. ,   Ryazan State Agrotechnological University named after P.A.Kostychev, Sadetdinov Sh.V. ,   I.N. Ulianov Chuvash State University, Stepanova E.I. ,   Ryazan State Agrotechnological University named after P.A.Kostychev
Published: May 2023

Using the methods of physicochemical analysis, a new borate nitrogen compound (C3H4N2 H3BO3 2H2O) was obtained, the study of the effect of which on the anticorrosion resistance of steel 10 in an aqueous medium allows us to conclude that it has a greater inhibitory effect compared to boric acid and imidazole. With an increase in the concentration of the compound in the medium under study, the corrosion rate decreases. The resulting compound is an effective corrosion inhibitor of predominantly anodic action for use as part of various process media in the repair industry.
Prospects for the Strategic Development of Rural Areas
Authors:   Rosinformagrotekh, Ukhalina O.V.
Published: May 2023

The subject matter of the strategic development of rural areas is revealed, taking into account state support and initiatives of state regulation in the field of spatial development. The special role of the state program of the Russian Federation “Integrated Development of Rural Territories”, as well as the allocation of supporting settlements in rural areas as strategic centers of social and economic development, is noted. It is proposed to pay more attention to training specialists in the regions on the issues of strategic planning of rural development.
Safty Issue in Anesthesia in Bangladesh
Authors: Banik Debabrata
Published: May 2023

Abstract not available
JBSA 2016; 29(2):35-37
Pengaruh Penambahan Tepung Mokag Tehadap Tingkat Kesukaan Konsumen Pada Kerupuk Biji Durian
Authors: Cahyani Dwi Ari
Published: May 2023

Crackers are a type of snack that is favored by consumers of all ages. Crackers can be consumed directly as a snack or as a side dish. One of the factors that determine the quality of crackers is the crispness. Durian is one of the many local fruits produced in Banjarnegara Regency. Durian consists of skin, flesh and seeds. When the durian season arrives, the seeds and skin of the durian become waste that is not utilized. The nutritional content of durian seeds which is quite a lot can be used as processed food that can be consumed by the community. Mocaf flour (Modified cassava flour) is a flour product derived from cassava which is processed using the principle of modifying cassava cells by fermentation. Based on the background of previous research results, it can be formulated the problem that underlies this research, namely how the right composition of durian seeds and mokaf flour and the length of time for boiling durian seeds to produce durian seed crackers are favored by consumers. This study aims to determine the level of consumer preference from the taste, color, texture and aroma of the durian seed crackers produced. This study used fresh durian seeds collected at durian sellers in the Sigaluh area, Banjarnegara Regency. The research was carried out at the Agricultural Product Processing Laboratory and Production Unit of the Banjarnegara Polytechnic Agroindustry Study Program. This study applies experimental research methods. The experimental design used was a completely randomized design with 3 replications. The hedonic test used 25 semi-trained panelists and the test results were analyzed using Anova. Furthermore, a follow-up test was used to determine whether there was a significant difference between the various treatments using the DMRT (Duncan Multiple Range Test) test. The results showed that the panelists preferred mokaf durian seed crackers which were processed with 100% durian seeds boiled by boiling for 30 minutes without the addition of mokaf flour. The panelists' preference for the color of the durian seed crackers was significantly different when the durian seeds were boiled for 30 minutes. While the aroma of the durian seed crackers produced is significantly different from the crackers by boiling for 30 minutes
Pertumbuhan Stek Pucuk Mangga (Mangifera indica L.) terhadap Respon Konsentrasi IBA (Indole Butyric Acid) dan Macam Media Tanam
Authors: Zainol Arifin Zainol Arifin , Ida Sugeng Suyani  , Aprilia Hartanti
Published: May 2023

Mango (Mangifera indica L.) is a fruit plant that has long been known and has become a commodity that has high economic value and is a trade commodity between countries. Vegetative propagation technique is an alternative to reproduce this type of plant. This study aims to: 1) Determine the concentration of IBA (Indole Butyric Acid) which affects the growth of mango shoot cuttings (Mangifera indica L.). 2) Knowing the planting media that affect the growth of mango shoot cuttings (Mangifera indica L.). 3) To determine the interaction between the concentration of IBA (Indole Butyric Acid) and the planting medium which influences the growth of mango shoot cuttings (Mangifera indica L.). The research was carried out using Factorial Randomized Block Design (RBD) with 2 factors. The first factor was the concentration of IBA (Indole Butyric Acid) (0 ppm, 500 ppm and 1000 ppm) and the second factor was the planting medium (sand, husk charcoal and sand + husk charcoal) with 3 replications. The results of this study were 1) There was an effect of IBA (Indole Butyric Acid) concentration treatment on the growth of mango shoot cuttings (Mangifera indica L.). The effect occurred on the percentage of growing cuttings, days of shoot break, shoot length, and number of leaves. 2) There is an effect of growing media treatment on the growth of mango shoot cuttings (Mangifera indica L.). The effect occurred on the percentage of growing cuttings, shoot length and number of leaves. 3) There was no interaction between the treatment of IBA (Indole Butyric Acid) concentrations and the growing media on the growth of mango shoot cuttings (Mangifera indica L.).
Pengaruh Model Penanaman Turnera Subulata terhadap Populasi H. armigera dan B. tabaci Serta Musuh Alaminya pada Tanaman Tomat (L. esculentum Mill.)
Authors: Muninggar Ajeng Faradhila , Nanang Tri Haryadi
Published: May 2023

The tomato plant (L. esculentum mill) is a species of horticultural plant native to Latin America. It is one of the important horticultural plants and is included in the second largest vegetable after potatoes. Some of the main pests of tomato plants are B. tabaci and H. armigera which can lower production. Pest control using chemical pesticides can be reduced using growing refugia plants. This study was conducted to determine the effect of some models of reflux cultivation on natural enemy populations on tomato plants. This study used a Group Random Design consisting of 4 treatments: P0 (Control), P1 (Border Model), P2 (Strip Model), P3 (Random Model) each treatment was repeated 6 times. Research results show that the Border's reflux planting model has a good influence on the natural enemy population with the highest population obtained in the treatment of P1 (Border), with an average natural enemy population of 27 at most. This has a good effect on the decline of the pest population with the lowest average population obtained in the treatment of P1 (Border) and the highest pest population in the treatment of P0 (Control) at 2.85.
Pertumbuhan dan Hasil Beberapa Varietas Padi Gogo Toleran Alumunium di Lahan Kering Masam Lampung Timur
Authors: Priyadi  , Taisa Rianida , Dulbari  , Rahmadi Rizky , Rochman Fajar
Published: May 2023

Aluminum stress is a limiting factor for crop production on acid dry land with a low pH. The objectives of this study were to evaluate aluminum-tolerant upland rice varieties in acid dry land. The study was carried out using a completely randomized block design (RCBD) consisting of 8 varieties, namely IR64, Inpago 7, Dodokan, Dod-Pup1, Situ Bagendit, Situ Bg-Pup1, Batur, Batur-Pup1, and 4 strains, namely 19 (PB5)-2, 20 (PB8)-1, 21 (PB15)-1, and 22 (PB16)-1. The results showed that the Situ Bagendit variety with the Pup-1 locus gave the highest yield per plot compared to other varieties and lines, namely 287.5 g. These results also correlate with the ability of the variety to withstand aluminum stress, with a tolerance value of 3.00 (rather tolerant).
EFEKTIVITAS PENGGUNAAN MEDIA BOARD GAME TERHADAP PENINGKATAN HASIL BELAJAR SISWA
Authors: Sakti Hadi Gunawan , Kartiani Baiq Sarlita
Published: May 2023

Abstract: Based on observations made at SMKN 1 Lingsar, it was found that the learning process still uses conventional methods and modules as learning media so that student interest and learning outcomes are low. To overcome this, interesting and fun learning is applied, one of which is by using the learning media "Board game" with the hope of improving student learning outcomes.  The purpose of this study is to determine the effectiveness of using Board Game Media in improving the learning outcomes of Class X Students in English Language Subjects at SMKN 1 Lingsar, West Lombok Regency for the 2021/2022 academic year. The data collection methods used in this study are tests as the main method, observation and documentation as complementary methods. The data analysis technique uses the t-test formula. The results of the analysis obtained a tcount value of 10.33 and a ttable value at a significant level of 0.05% = 2.056 with d.b (N-1) = 26-1 = 25 thus that the tcount value is greater than the ttable (10.33> 2.056). This means that the null hypothesis is rejected and the alternative hypothesis is accepted which reads: There is an Effectiveness of Using Board Game Media on Improving Learning Outcomes in English Subjects for Class X Students of SMKN 1 Lingsar in the 2022/2023 Academic Year. So it can be concluded that the results of this study are "Significant". Keywords: Learning Media, Board Game, Learning Outcomes.
The Portrayal of Women in Indian Television Advertisements and its Impact on Indian Women
Authors: Lal Suman
Published: May 2023

Since the beginning of the liberalisation process, television advertisements have made a massive impact around the world. Especially today, television advertisements play a major role in entertainment and information in Indian society. But from the past few decades, Indian television advertisements have been not only providing information about the product or services and, but also directly and indirectly, also forcing the audience to buy their product, in different ways, especially by affecting the psychology of the people as viewers or consumers. If observed closely, TV advertisements continuously objectify women’s bodies, sexuality and pornographic image for the sake of their products and services, for them, women are merely a commodity to attract viewers' attention towards their product. In India, almost three decades have passed since the beginning of globalisation in 1990, but despite the many positive changes in society, economy, and politics, Indian commercials are still very regressive towards women. The content analysis and interview methods have been used under the qualitative approach to collect accurate data. By using these two methods I have examined and explained how the commodification of women is more often shown in television advertisements to sell anything and this objectification affects women's capabilities as a person
Work and care: gender inequalities in the COVID-19 pandemic in El Salvador
Authors: Jose Erazo Maria
Published: May 2023

Care work is vital for social reproduction but relies almost exclusively on women; in addition to this, social reproduction activities are generally unpaid, undermining their role in sustaining the economy and life itself. This historic burden on women impacts their access to the labor market, the quality of their jobs, and their physical, mental, and emotional health. In this paper, we find evidence of gender inequalities in the labor market and their relationship with time allocation and unpaid care work in El Salvador, a Central American country. We use the Encuesta de Hogares de Propósitos Múltiples for 2019 and 2020 to identify the hours women and men spent in care before and during the COVID-19 pandemic, and how they differ according to their position in the workforce, the presence of children, and their ages. According to the results, in 2019, female workers allocated 22.6 hours per week to care activities and 26.8 hours when they had children, while men spent 7.6 hours per week and 8.8 when they had children. This shows that women work three times more per week in care activities than men, and even more when they have children. Additionally, the care workload increases to up to 33.6 hours per week for women with children of 5 years old or younger. Since many women had to work from home during the pandemic, social reproduction activities overlapped with their job responsibilities. In fact, in 2020, the care workload demanded up to 24 hours per week from female workers’ time, 28 if they had children, while men allocated 8 to 9 hours per week to these activities. This work intensity requires women to stop working or to become self-employed, more likely in the informal sector.
Performance Art and Feminism: Bodies of Care and Patience
Authors: Alexandra Antoniadou
Published: May 2023

This paper examines the concepts of “care” and “patience” under capitalism and in relation to social reproduction theory through performative works of art. The idea that reproduction is not about creating life but instead the creation of new workers has preoccupied a new wave of feminist theorists and activists who wish to explore women’s place and labour in and outside the sphere of production and explain the relationship between oppression and exploitation. Although working class women have been carrying the burden of the extra physical, mental and emotional labour generated by the Coronavirus disease of 2019, social reproduction theorists and survey data show that women have been performing a disproportionate amount of unpaid care and housework long before the pandemic. The feminisation and devaluation of care labour that patriarchal capitalism promotes can only lead to women’s systematic subjugation. Through the critical feminist analysis of performative works by Chrysi Tsiota, Fotini Kalle and Angeliki Avgitidou that draws on the writings of Silvia Federici, Tithi Bhattacharya and Emma Dowling among others, and the theorisation of “patience” by philosophers Slavoj Žižek and Alain Badiou this paper interconnects the notions of care and patience to expose women’s economic and sexist exploitation and deepen our understanding of everyday life in neoliberal capitalism. Arguing that despite the intense engagement of Greek women artists with issues around reproductive labour, the lack of a feminist art history and theory in Greece has led to the marginalisation of such discussions, this paper aims to bring in light important works of performance art and the necessity for such issues to be addressed within the Greek borders.
Grandes animais como modelos experimentais em estudos de falhas ósseas críticas: um protocolo para revisão sistemática
Authors: Cardoso Marilia Nunes , Souza Anderson Fernando de , De Zoppa André Luis do Valle
Published: May 2023

Introdução: modelos animais são essenciais para avaliar a biocompatibilidade, resposta tecidual e função mecânica de materiais ortopédicos utilizados no tratamento de falhas ósseas críticas. Objetivo: apresentar um protocolo de revisão sistemática para identificar e sumarizar a abordagem experimental para ensaios pré-clínicos de falhas ósseas críticas, em grandes animais. Metodologia: o protocolo foi desenvolvido baseado em Preferred for Systematic Review and Meta-Analysis Protocols (PRISMA-P) Guidelines. O levantamento bibliográfico será realizado nas bases de dados PubMed, Scopus, Embase e Google Scholar. Serão considerados estudos pré-clínicos na língua inglesa, portuguesa ou espanhola, que utilizem grandes animais como modelos de falhas ósseas críticas. Os artigos serão analisados por dois revisores, de forma independente. Em caso de divergências, o terceiro revisor será consultado. A revisão sistemática será baseada em Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) Guidelines. Considerações finais: a revisão sistemática proposta faz-se necessária para a padronização de modelos de estudo experimental em falhas ósseas críticas.
Entardecer Científico: formação universitária a favor da sociedade
Authors: Pereira Helena Isaura Fernandes , Freitas Janainna Valéria Duarte , Hartwig Shaiana Vilella , Barros Bruna Keiko Yoshino , Vasconcelos Rosane Maria Andrade , Cardoso Luana Paula da Silva , Silva Thamires Alves da , Pires Gabriela de Souza , Fernandes Vittoria Hellen Pereira , Souza Stefany Caroliny de
Published: May 2023

Objetivo: Descrever a experiência dos extensionistas frente às ações do projeto Entardecer Científico no tocante a importância dos temas da saúde para a comunidade interna e externa. Metodologia: Trata-se de um estudo descritivo, reflexivo, de natureza qualitativa, do tipo relato de experiência, sobre o conhecimento vivenciado pelos extensionistas a partir das atividades e ações desenvolvidas no Projeto de Extensão Entardecer Científico na Universidade do Estado de Mato Grosso. Resultados: Durante o período de janeiro de 2021 a junho de 2022 foram realizados 17 eventos de forma remota e online com transmissão pelo YouTube devido a pandemia da COVID-19. Todas as atividades foram realizadas por um grupo de acadêmicos de enfermagem coordenados por um professor participante do projeto. A equipe definiu a temática, convidou o palestrante e desenvolveu toda a parte burocrática e organizacional no intuito da realização da palestra. Após o evento, a equipe escreve o relatório final do evento, a escrita científica da apresentação, divulgação dos resultados e dificuldades encontradas. Estes resultados serão divulgados por meio de resumo simples, resumo expandido, artigo de revista e capítulo de livro. Conclusão do estudo: A capacitação de acadêmicos e profissionais da saúde por meio de palestras é de extrema importância e tornou-se ainda mais necessária diante da pandemia. Participar de ações extensionistas contribui com a promoção do compartilhamento de conhecimento por meio de palestras, amplia o conhecimento do tema saúde para o discente e para a sociedade. Oportuniza trabalhar as competências de comunicação, liderança colaborativa, relacionamento interpessoal e trabalho em equipe.
Extracciones dentarias como alternativa de tratamiento en casos de clase esqueletal I en adultos jóvenes con apiñamiento severo: Revisión de Literatura
Authors: Quezada Ortega Daleska Gianella , Ramos Montiel Ronald Roossevelt
Published: May 2023

Objetivo: Determinar qué tipo de extracciones dentarias son las más habituales a utilizar como alternativa de    tratamiento para casos de clase esqueletal I en adultos jóvenes con apiñamiento severo. Materiales y Métodos: La literatura se seleccionó mediante una búsqueda en las bases de datos electrónicas: Pubmed, Lilacs, Scopus, Cochrane, Epistemonikos, Pesquisa, Taylor & Francis, Ovid, Dialnet, Proquest, y Google Academic. Las palabras clave utilizadas fueron: Maloclusión, clase esqueletal I, Extracciones dentales, apiñamiento dental. La búsqueda se restringió a artículos en inglés, español y portugués publicados desde el año 2018 hasta el año 2023. Resultados: Después de aplicar los criterios de inclusión en total se obtuvieron y revisaron 24 artículos. Determinando qué la solución principal al apiñamiento de los dientes frontales inferiores es la extracción dental o el uso de métodos de reducción del esmalte interproximal; el apiñamiento da como resultados dientes desalineados junto con una maloclusión. Conclusión: La literatura disponible reveló que la decisión sobre extracción y no extracción es individual para cada caso, la extracción de los cuatro primeros premolares permite una mejora significativa de la estética dental y del margen gingival, lo que brinda al paciente una sonrisa agradable y armónica proporcionando estabilidad por los próximos años.
Volumização Labial na HOF: Uma Revisão Narrativa da Literatura
Authors: Contador Erika Bassan , Suguihara Roberto Teruo , Muknicka Daniella Pilon
Published: May 2023

A harmonização orofacial é uma especialidade odontológica precedente da necessidade em ampliar e associar tratamentos entre as estruturas intra e extraorais, reabilitando funções e reestruturando unidades anatômicas que ao longo do tempo sofreram alterações, possibilitando restituir ao paciente confiança e auto estima entre diversas faixas etárias. O objetivo do trabalho é salientar a importância do lábio e a harmonia da face, através de proporções e medidas labiais, considerando a individualidade e a percepção da sociedade, devolvendo satisfação ao paciente. A coleta de dados ocorreu nas bases PubMed, LILACS e Scielo, indicando no campo de pesquisa os seguintes descritores: “Lábio”, “Harmonização Orofacial” e “Estética”. Para a pesquisa avançada, correlacionando os termos, os operadores booleanos  e  foram utilizados. Não houve restrição para o tipo de artigo a ser inserido nas referências, bem como houve definição de limite de data de publicação de 09 anos. A análise para seleção dos artigos foi do tipo qualitativa, integrando toda e qualquer metodologia de pesquisa que relacione os termos “Lábio”, “Harmonização Orofacial” e “Estética”. Foram descritas textualmente as diversas aplicações e contexto da volumização labial dentro da especialidade de harmonização orofacial. Concluiu-se através dos estudos apresentados que não existe uma fórmula padrão, e sim uma correta avaliação e indicação de técnicas, cabendo ao profissional adequá-las diante da diversidade.
Atualização sobre a esquistossomose mansônica no Brasil: uma revisão integrativa
Authors: Souza Isaias Sena Moraes de , Pereira Laura Maria de Araújo , Neves Senyra Maria das , Farias Dominique de Souza , Inocêncio Jemima Silva , Lucena Neto Luiz Marinho de , Dias Jhonatta Alexandre Brito , Vital Júnior Antonio Carlos , Gonçalves Daniel José , Pereira Helimarcos Nunes , Silva Júnior José Guedes da
Published: May 2023

O presente trabalho realiza uma revisão integrativa da literatura sobre a esquistossomose no Brasil, uma doença parasitária e de veiculação hídrica, causada por platelmintos do gênero Schistosoma (S. mansoni; S. japonicum; S. haematobium), e que ainda se manifesta como problema de saúde pública significativo neste país. Visa destacar dados clínicos, bem como dados epidemiológicos, apresentando as regiões mais afetadas, indivíduos mais vulneráveis à infecção e fatores associados à sua ocorrência. Além disso, objetiva atualizar o cenário atual no que diz respeito ao desenvolvimento de uma vacina contra os parasitos causadores da esquistossomose. O estudo realizou análises nos bancos de dados PubMed e Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), ScienceDirect, bem como fez uso de dados da Organização Mundial de Saúde (OMS), do Centers For Disease Control and Prevention (CDC) e do Ministério de Saúde do Brasil (MS). Conclui-se que a esquistossomose permanece como uma doença de elevada relevância nacional, visto que ainda se manifesta como um problema de saúde pública, responsável por intensificar quadros de desigualdade social e possuir ligação direta com a pobreza, como causa, mas também como consequência da mesma. Atualmente, diversas vacinas encontram-se em fases de teste clínico, porém nenhuma está disponível comercialmente, sendo de grande importância o investimento em pesquisa.
Teacher Expertise of Academics in Research-Intensive Universities
Authors:   , van Dijk Esther Eline
Published: May 2023

To better support academics in their development as university teachers and to improve recognition of academics’ teaching achievements, a better understanding is needed of academics’ teacher expertise. The studies in this thesis contribute to advancing this understanding in three ways. Firstly, this thesis demonstrates the multifaceted nature of academics’ teacher expertise. The systematic review in this thesis shows that academics’ teacher expertise development involves six teacher tasks and at least three dimensions for expertise development in these tasks. Secondly, this thesis sheds light on how academics’ expertise development in various teacher tasks may be interrelated. Two studies with data about academics’ perceived teacher expertise advance our understanding of academics’ expertise development in various teacher tasks over time and as well as the relationships between the teacher tasks that play a role in this development. A general pattern for academics’ teacher expertise development over time was identified, although with individual exceptions. A subset of teacher tasks was experienced as closely connected. The other teacher tasks were experienced as more loosely coupled to this set of tasks and to each other. All tasks were found to be interrelated through mutually beneficial relationships, meaning that expertise in one task contributed to expertise in another and vice versa. Thirdly, the conceptual analysis in the final study of this thesis provides insight into how academics’ disciplinary knowledge relates to their development as university teachers. Academics’ disciplinary knowledge is not only important for academics’ understanding of the content they are teaching and how to best teach about this content, but also for their decisions about what content taught in the first place. The methodologies and instruments that were used in this thesis as well as the developed conceptualisation of academics’ teacher expertise and its development provide a foundation for future research. Insights from this thesis also provide suggestions for how academics’ teacher expertise development may be strengthened as well as for shaping policies for recognition and reward.
Trade Wars Are Class Wars, How Rising Inequality Distorts the Global Economy and Threatens International Peace
Authors: KÖSE Yaşar
Published: May 2023

The purpose of the book is to provide an understanding of how trade conflicts and the inequalities that come with them are created in the global economy. The authors' arguments are that trade wars are class wars between elites and workers within countries, which create increasing inequalities between classes in countries, disrupting the global economy and threatening international peace.
Is It a Wonderful Life? Frank Capra and Objective List Theories of Worth
Authors: Shaw Joshua
Published: May 2023

Aaron Smuts argues that the holiday film It's a Wonderful Life should be understood as both an illustration and a cinematic vindication of objective list theories of worth. This article argues that he is right about the first point but wrong about the second. It's a Wonderful Life is an excellent illustration of objective list theories. However, it also exposes a problem for them – their susceptibility to sceptical anxieties about whether we can know if our lives are worth living. More specifically, I argue that It's a Wonderful Life shows how our lives are vulnerable to two sceptical anxieties, one arising from our potential inability to confirm our successes in promoting the good, the other from our potential inability to ascertain which goods can properly be said to be in our lives due to gaps in our self-knowledge and our potential for self-deception.
Leveraging mice with diverse microbial exposures for advances in osteoimmunology
Authors: Little-Letsinger Sarah E. , Hamilton Sara E.
Published: May 2023

The skeletal and immune systems are intricately intertwined within the bone marrow microenvironment, a field of study termed osteoimmunology. Osteoimmune interactions are key players in bone homeostasis and remodeling. Despite the critical role of the immune system in bone health, virtually all animal research in osteoimmunology, and more broadly bone biology, relies on organisms with naïve immune systems. Drawing on insights from osteoimmunology, evolutionary anthropology, and immunology, this perspective proposes the use of a novel translational model: the dirty mouse. Dirty mice, characterized by diverse exposures to commensal and pathogenic microbes, have mature immune systems comparable to adult humans, while the naïve immune system of specific-pathogen free mice is akin to a neonate. Investigation into the dirty mouse model will likely yield important insights in our understanding of bone diseases and disorders. A high benefit of this model is expected for diseases known to have a connection between overactivation of the immune system and negative bone outcomes, including aging and osteoporosis, rheumatoid arthritis, HIV/AIDS, obesity and diabetes, bone marrow metastases, and bone cancers.
Emergence of a novel reassortant H3N6 canine influenza virus
Authors: Meng Bo , Li Hailing , Feng Chong , Guo Weiwei , Feng Yali , Zhu Dawei , Chen Hualan , Zhang Ying
Published: May 2023

Although the natural hosts of avian influenza viruses (AIVs) are wild birds, multiple subtypes of AIVs have established epidemics in numerous mammals due to their cross-species spillover. Replication and evolution in intermedia mammalian hosts may facilitate AIV adaptation in humans. Because of their large population and intimacy with humans, dogs could act as such an intermedia host. To monitor the epidemiology of canine influenza viruses (CIVs) in Liaoning, China, we performed three surveillances in November 2018, March 2019, and April 2019. Five H3N2 and seven novel H3N6 CIVs had been isolated. Since the N6 neuraminidase (NA) genes were clustered with the H5N6 AIV, there is a high possibility that these H3N6 CIVs were generated from a H3N2 CIVs and H5N6 AIVs reassortment case. In addition, the H3N6 CIV showed increased mammalian adaptation ability compared to all the H3N2 strains in both in vitro and in vivo studies. Even though isolated 3 months later, the March 2019 isolated H3N2 viruses replicated more efficiently than the November 2018 isolated viruses. Our study indicated that H3 CIVs were undergoing an evolution process, through both genetic mutations and gene reassortment, at an incredible speed.
Effects of silent brain infarction on the hemorrhagic transformation and prognosis in patients with acute ischemic stroke after intravenous thrombolysis
Authors: Zhang Lulu , Wang Shan , Qiu Lanfeng , Jiang Juean , Jiang Jianhua , Zhou Yun , Ding Dongxue , Fang Qi
Published: May 2023

Background

Silent brain infarction (SBI) is a special type of stroke with no definitive time of onset, which can be found on pre-thrombolysis imaging examination in some patients with acute ischemic stroke (AIS). However, the significance of SBI on intracranial hemorrhage transformation (HT) and clinical outcomes after intravenous thrombolysis therapy (IVT) is uncertain. We aimed to explore the effects of SBI on intracranial HT and the 3-month clinical outcome in patients with AIS after IVT.

Methods

We consecutive collected patients who were diagnosed with ischemic stroke and received IVT from August 2016 to August 2022, and conducted a retrospective analysis in this study. The clinical and laboratory data were obtained from hospitalization data. Patients were divided into SBI and Non-SBI groups based on clinical and neuroimaging data. We use Cohen’s Kappa to assess the interrater reliability between the two evaluators, and multivariate logistic regression analysis was used to further assess the association between SBI, HT and clinical outcomes at 3 months after IVT.

Results

Of the 541 patients, 231 (46.1%) had SBI, 49 (9.1%) had HT, 438 (81%) had favorable outcome, 361 (66.7%) had excellent outcome. There was no significant difference in the incidence of HT (8.2 vs. 9.7%, p = 0.560) and favorable outcome (78.4% vs. 82.9%, p = 0.183) between patients with SBI and Non-SBI. However, patients with SBI had a lower incidence of excellent outcome than the patients with Non-SBI (60.2% vs. 71.6%%, p = 0.005). After adjustment for major covariates, multivariate logistic regression analysis disclosed that SBI was independently associated with the increased risk of worse outcome (OR = 1.922, 95%CI: 1.229–3.006, p = 0.004).

Conclusion

We found that SBI was no effect for HT after thrombolysis in ischemic stroke patients, and no effect on favorable functional outcome at 3 months. Nevertheless, SBI remained an independent risk factor for non-excellent functional outcomes at 3 months.
RNA-sequencing approach for exploring the protective mechanisms of dexmedetomidine on pancreatic injury in severe acute pancreatitis
Authors: Yao Jiaqi , Lan Bowen , Ma Chi , Liu Yan , Wu Xiaoqi , Feng Kaixuan , Chen Hailong , Wen Qingping
Published: May 2023

Background: Severe acute pancreatitis (SAP) is a severe form of acute pancreatitis with the potential to cause life-threatening complications. Patients with acute SAP require surgical intervention and are admitted to the intensive care unit for non-invasive ventilation. Dexmedetomidine (Dex) is currently used by intensive care clinicians and anaesthesiologists as an adjunctive sedative. Therefore, the clinical availability of Dex makes it easier to implement in SAP treatment than developing new drugs.

Methods: Randomly dividing thirty rats into sham-operated (Sham), SAP, and Dex groups. The severity of pancreatic tissue injury in each rat was assessed by Hematoxylin and eosin (HE) staining. Serum amylase activity and inflammatory factor levels were measured using commercially available kits. The expressions of necroptosis-related proteins, myeloperoxidase (MPO), CD68, and 4-hydroxy-trans-2-nonenal (HNE) were detected using immunohistochemistry (IHC). Transferase-mediated dUTP nick-end labeling (TUNEL) staining was utilized to identify pancreatic acinar cell apoptosis. The subcellular organelle structure of pancreatic acinar cells was observed using transmission electron microscopy. The regulatory effect of Dex on the gene expression profile of SAP rat pancreas tissue was investigated using RNA sequencing. We screened for differentially expressed genes (DEGs). Quantitative real-time PCR (qRT-PCR) measured critical DEG mRNA expression in rat pancreatic tissues.

Results: Dex attenuated SAP-induced pancreatic injury, infiltration of neutrophils and macrophages, and oxidative stress. Dex inhibited the expression of necroptosis-associated proteins RIPK1, RIPK3, and MLKL and alleviated apoptosis in acinar cells. Dex also mitigated the structural damage caused by SAP to mitochondria and endoplasmic reticulum. Dex inhibited SAP-induced 473 DEGs, as determined by RNA sequencing. Dex may regulate SAP-induced inflammatory response and tissue damage by inhibiting the toll-like receptor/nuclear factor κB (TLR/NF-κB) signaling pathway and neutrophil extracellular trap formation.

Conclusion: This study elucidated the remarkable effect of Dex against SAP and investigated the potential mechanism of action, providing an experimental base for the future clinical application of Dex in the treatment of SAP.
Association between sleep quality and psychological symptoms: A cross-sectional survey of Chinese university students performed during the COVID-19 pandemic
Authors: Hu Yanyan , Liu Jingzhi , Zhao Zhimin , Bi Cunjian , Cao Hongmin , Liu He , Yang Guangyan
Published: May 2023

Background

Since the start of the coronavirus 2019 pandemic, people have faced many challenges, including in relation to sleep quality and psychological health. This study aims to analyze the association between sleep quality and psychological symptoms among university students in China, and to provide reference data to facilitate the development of interventions to improve the physical and mental health of university students.

Methods

A stratified cluster sampling method was used to investigate the sleep quality and psychological symptoms of 6,363 university students in China. The Chi-square test was used to analyze differences in sleep quality among groups. Logistic regression analysis was used to analyze the association between sleep quality and psychological symptoms.

Results

The proportions of Chinese university students with good, medium, and poor sleep quality were 25.73, 10.99, and 63.28%, respectively. The overall rate of psychological symptoms was 16.5%. Logistic regression analysis showed that, in general, university students with poor sleep quality had a higher risk of psychological symptoms than those with good sleep quality (OR = 1.53, 95%CI: 1.28, 1.84, p < 0.01). Compared with university students with good sleep quality, those with poor sleep quality were more likely to experience emotional symptoms (OR = 1.62, 95%CI: 1.36, 1.94), behavioral symptoms (OR = 1.55, 95% CI: 1.3, 1.84), and difficulties with social adaptation (OR = 1.84, 95% CI: 1.51, 2.25) (all p < 0.01).

Conclusion

There was an association between sleep quality and psychological symptoms among Chinese university students. University students with poor sleep quality have a higher risk of psychological symptoms. Measures should be taken to improve the sleep quality of university students and reduce the incidence of psychological symptoms. This study provides reference data for government and education departments that could inform public health policies.
Association between parental separation, childhood trauma, neuroticism, and depression: a case control study
Authors: Sanwald Simon ,   GenEmo Research Group, Montag Christian , Kiefer Markus
Published: May 2023

Background

Parental separation has been suggested to be associated with depression development in offspring. The new family constellation subsequent to separation could be associated with elevated scores of childhood trauma, shaping more emotionally instable personalities. This could ultimately be a risk factor for mood disorders and particularly the development of depression in life.

Methods

To test this hypothesis, we investigated the associations between parental separation, childhood trauma (CTQ) and personality (NEO-FFI) in a sample of N = 119 patients diagnosed with depression and N = 119 age and sex matched healthy controls.

Results

While parental separation was associated with elevated scores of childhood trauma, there was no association between parental separation and Neuroticism. Furthermore, in a logistic regression analysis, Neuroticism and childhood trauma were found to be significant predictors for depression diagnosis (yes/no), but not parental separation (yes/no).

Conclusion

Parental separation might be associated with depression only indirectly via childhood trauma. Childhood trauma or Neuroticism seem more directly related to the development of depression. However, it is worthwhile to install prevention programs helping parents and children to cope with parental separation in order to minimize the impact of separation and associated stressors.
Design and Experiment on a Distributed Seed Delivery System with a Pneumatic Central-Cylinder Seeder
Authors: Wang Baolong , Na Yi , Chen Mingyang , Ge Zhenbo , Pan Yihong , Liu Jian , Wu Wei , Luo Xiwen
Published: May 2023

A distributed seed delivery system is the most important component of a pneumatic central-cylinder seeder. We performed a fluent simulation analysis for seed-drop tubes at different parameters and airflow velocities, and with an increase in air velocity, the larger the angle is, the easier it is to produce a vortex, which considerably changes the angle, with the little bend tube improving the uniformity of seeding performance. The distribution of rice seeds in the seeding furrow using seed-drop tubes of different angles was also analyzed, and with an increase in delivery airflow velocity, the rice-sowing belts aggregated toward the seeding furrow central line, and with an increase in the forward speed, the seed distribution in the forward-speed direction presented an aggregation and then dispersion trend. The field experiment and physiological indices show that the yield of germination acceleration by seed pelleting can reach 7.92 t. ha−1, which was significantly higher than the yields with other treatments.