bluuebunny/crossref_metadata_2025 huggingface dataset:
A Feasibility Study of New Generation Pesticides Application
Authors:   Institute of Economics and Industrial Engineering SB RAS, Bryukhanova Elena A.
Published: April 2022

The paper presents the results of a feasibility study of long-term herbicidal and fungicidal preparations deposited with a degradable microbial poly‑3-hydroxybutyrate polymer base. Deposited pesticides, tribenuron-methyl and tebuconazole, were introduced into soil simultaneously with seeds of spring wheat Novosibirskaya 15. The control included a pre-sowing treatment of grain with the commercial fungicide «Bunker» and spraying the crops in the tillering phase with the herbicide «Mortira». The feasibility studies have shown that pre-emergence soil application of deposited pesticide preparations ensured cost savings in wheat production of 327.34 roubles per 1 ha, decreased the cost price of the product and increased the profitability of production by 66.1 % as compared with the traditional use of commercial pesticide preparations. Thus, elimination of pre-sowing seed treatment and spraying crops with herbicides during the growing season accompanied by a wheat yield increase resulted in reduced costs of production. Additionally, application of deposited pesticides may reduce the risk of uncontrolled spread and accumulation of xenobiotics in the biosphere
Exploring Women’s Uptake of Active Labour Market Programmes: The Role of Household Composition Across Migrant Origin Groups
Authors: Kasztan Flechner Tair , Neels Karel , Wood Jonas , Biegel Naomi
Published: April 2022

Active labour market policies, like training, aim to increase the employability of unemployed population subgroups. Research indicates that the most vulnerable groups—such as women of migrant origin—are less likely to participate in the most effective programmes. Prior studies have established that household composition affects the labour market outcomes of women without and with a migration background. In contrast, research has not addressed the potential relevance of household composition in relation to women’s training uptake. Using hazard models and longitudinal microdata from the employment office and social security registers, we analyse the extent to which women’s household composition such as the presence and the origin of their partner or the presence of children is associated with the uptake of occupation‐specific training in Flanders (Belgium). Our results suggest that, even when we control for previously identified determinants of training uptake such as the human capital of unemployed women, training uptake in most groups varies by household composition. More specifically, the results suggest that women with a partner of non‐migrant origin show higher cumulative uptake than women with a migrant origin partner or single women, and that the presence of children in the household reduces women’s training participation. Furthermore, household composition is found to be a stronger differentiating factor in uptake for migrant origin women than for non‐migrant origin women.
INTRUSIVE-MAGMATIC COMPLEXES OF WILHELM ARCHIPELAGO, WEST ANTARCTICA (PART 1 – INTRUSIONS OF GABBROIDS, DIORITES AND GRANITOIDS)
Authors:   Taras Shevchenko National University of Kyiv, Mytrokhyn O. , Bakhmutov V. ,   Institute of Geophysics, National Academy of Sciences of the Ukraine, Aleksieienko A. ,   Taras Shevchenko National University of Kyiv, Mytrokhina T. ,   Taras Shevchenko National University of Kyiv, Marushchenko O. ,   Taras Shevchenko National University of Kyiv
Published: April 2022

The Wilhelm Archipelago and the adjacent coast of Graham Land are typical areas of calc-alkaline magmatism associated with the protracted evolution of the Antarctic Peninsula igneous belt. The authors studied intrusive complexes of the Wilhelm Archipelago (WA) in order to characterize their geographical distribution, geological occurrence and age, mineralogical and petrographical features. Geological surveys revealed that gabbro, diorite, and granitoid intrusions are widespread on the WA. Due to the processes of tectonic uplift and exhumation, both apical and bottom parts of individual intrusive bodies can be exposed on the modern erosion level. Recent geological observations have shown that plutons of different ages intersect each other in a complex sequence. This made it possible to determine their relative geological age and reconstruct the general direction of the deep magmatic development from the Early Cretaceous to the Early Paleogene, inclusive. It has been proved that the oldest massifs of gabbroids are parts of much larger intrusive bodies. They were formed in the period between the Jurassic and the Early Cretaceous periods. Crystallization differentiation of basaltic magmas gave them various scale layering. In the bottom parts of gabroid intrusions there were conditions for the formation of Fe-Ti-V and Cu-Ni-EPG mineralization. Diorite and granitoid intrusions occupy much larger areas compared to gabbroids. The formation of diorite intrusions took place in the period between the Early Cretaceous and the Paleocene. Although the oldest gabbroids were formed much earlier than diorites, the phenomena of magmatic mingling in the latter indicate that magmas of basic and intermediate composition could also synchronously intrude in common magmatic chambers. Granitoid magmatism on the WA covers the Late Cretaceous and the Paleogene periods. Most granitoid intrusions formed in the Paleocene after the main phase of tectonic deformations. Cu-Mo mineralization may be associated with these intrusions.
NANOSTRUCTURES IN THE SURFACE LAYERS OF COAL MATTER
Authors:   Technical University of Karaganda, Portnov V. , Yurov V. ,   E.A. Buketov University of Karaganda, Reva N. ,   Taras Shevchenko National University of Kyiv, Mausymbaeva A. ,   Nazarbayev University, Imanbaeva S. ,   Technical University of Karaganda
Published: April 2022

According to modern concepts, the surface layer of compounds is understood as the ultrathin cover, the properties, structure and composition are different from the crystalline substrate with this layer and this layer is in thermodynamic equilibrium. The surface layer consists of two layers - d(I) with thickness h = d, at which the phase transition occurs, and d(II) with the lower limit h≈10d, at which the physical properties of the crystal begin to manifest themselves. The thickness of the surface layer d(I) is determined by one fundamental parameter, the molar (atomic) volume of the element (Ʊ= M/ρ, M is molar mass (g/mol), ρ is density (g/cm3)). The average statistical structural unit of coal corresponds to higher fullerenes with the number of carbon atoms in the cluster >100, which is the unique feature of the coal substance, which is not a crystalline structure, but a complex polymer with a supramolecular structure. The thickness of the surface layer of the coal substance is two orders of magnitude greater than the thickness of pure metals and is close to the thickness of the surface layer of higher fullerenes C96 (135 nm). The increasing of the coal substance's porosity of 90 % is led to increasing the thickness d(I) of the surface layer by the order of magnitude, that is 2 microns. In this regard, the "apparent" change in the radius of a coal particle means a change in its mass, proportional to the release of methane from the solid solution. The dependence of the complete decomposition's time of coal methane is τ0 on the parameter |λ|. The equation which is obtained, includes the ratio of the heat flux introduced into the reservoir volume due to the internal heat release process to the heat flux which is carried away from the volume due to thermal conductivity. If this ratio exceeds a certain critical value of the unity's order, the thermal explosion occurs, leading to the decomposition of coal methane. The size effects in the d(I) layer are determined by the entire group of atoms in the system (collective processes). Such "quasi-classical" size effects are observed only in nanoparticles and nanostructures. The d(I) layer for coal matter extends from 151.5 nm (Anthracite) to 214.2 nm (Brown). The dimensional temperature of the carbon nanoparticle at the initial temperature T0 = 300 K will be at least Tm = 872 K. This corresponds to particles of the order of half a micron. Coal particles with the radius of about one micron (or marked half a micron) in the case of decomposition of coal matter are heated to temperatures at which spontaneous combustion of nanoparticles is possible. Hygroscopic moisture in the genetic line of coal has the certain pattern of change and correlates with the thickness of their surface layer.
ACHIEVING SUSTAINABILITY IN COUNTRIES WITH ECONOMIES IN TRANSITION: NEW OPPORTUNITIES AND PROSPECTS
Authors:   Karaganda Technical University, Aubakirova G. , Rudko G. ,   State Commission of Ukraine on Mineral Reserves, Vyzhva S. ,   Taras Shevchenko National University of Kyiv, Portnov V. ,   Karaganda Technical University, Isatayeva F. ,   Karaganda Technical University, Zimanovskaya N. ,   East Kazakhstan state technical university named. D. Serikbaev
Published: April 2022

The article examines Kazakhstan, the largest economy in Central Asia, which, on the way to sustainable economic growth, adequately responds to systemic challenges and adapts the experience of advanced countries. The generalizing indicators of the effectiveness of state regulation of the processes contributing to the growth of the stability of the national economy are given. The reasons for the weak involvement of entrepreneurs and citizens in measures for the sustainable development of Kazakhstan have been identified. It has been substantiated that the development of a strategy for the country's sustainable development and the achievement of inclusive economic growth require coordination of the work of government bodies, business and civil society. It is shown that in Kazakhstan the main drivers for the implementation of the culture of sustainable development are large enterprises and the quasi-public sector. Private enterprises do not yet see the opportunity to profit from integrating sustainable development goals into business processes. The paper emphasizes that in order to increase the stability of the poorly diversified economy of Kazakhstan, emphasis should be placed on the transformation of the mining sector, which has the potential to maintain investment attractiveness, both for domestic and foreign investors. Based on the results of the study, the authors highlight the most important aspects of building a new model of sustainable development in the foreseeable future.
Eigenfrequencies and eigenforms of regular chain oscillatory systems
Authors:   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute, Khoroshev K. G. , Kykot S. V. ,   National transport university
Published: April 2022

The classical approach in the investigation of natural oscillations of discrete mechanical oscillatingsystems is the solution of the secular equation for finding the eigenfrequencies and the system of algebraic equations for determining the amplitude coefficients (eigenforms). However, the analytical solution of the secular equation is possible only for a limited class of discrete systems, especially with a finite degree of freedom. This class includes regular chain oscillating systems in which the same oscillators are connected in series. Regular systems are divided into systems with rigidly fixed ends, with one or both free ends, which significantly affects the search for eigenfrequencies and eigenforms. This paper shows how, having a solution for the secular equation of a regular system with rigidly fixed ends, it is possible to determine the eigenfrequencies and eigenforms of regular systems with one or both free ends.
Methodology for building a functionally stable intelligent information system of a manufacturing enterprise
Authors:   Taras Shevchenko National University of Kyiv, Sobchuk Valentyn , Zamrii Iryna ,   State University of Telecommunications, Barabash Oleg ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute", Musienko Andrii ,   National Technical University of Ukraine “Igor Sikorsky Kyiv Polytechnic Institute"
Published: April 2022

The article analyzes the concept of process management in an industrial enterprise, which provides functional stability of technological processes using information systems of various types and allows to increase productivity of all production centers while reducing the number of people employed in production and the impact of various destabilizing factors. The research of existing mathematical models of functionally stable complex technical systems and formalization of the main types of procedures of the process of functioning of the intellectual information system of the enterprise is carried out. The method of ensuring the properties of functional stability of the intelligent information system of the enterprise is improved by presenting the functioning of the system in the form of a formalized process, in which the main types of procedures are accumulation of tests, analysis of test links, diagnosing a failed module and restoring the system. This technique allows to ensure the property of functional stability of the information system of the enterprise.
ERGENLERDE DUYGU DÜZENLEME, PSİKOLOJİK SAĞLAMLIK VE OKULDA ÖZNEL İYİ OLUŞUN AKILLI TELEFON BAĞIMLILIĞI ÜZERİNDEKİ YORDAYICI ROLÜ
Authors: Sağar Mehmet Enes
Published: April 2022

Bu araştırmada, duygu düzenleme, psikolojik sağlamlık ve okulda öznel iyi oluş değişkenlerinin ergenlerin akıllı telefon bağımlılığı düzeylerini ne kadar yordadığı incelenmiştir. Araştırma grubu 167 (%46.9) erkek ve 189 (%53.1) kız olarak toplam 355 ergenden meydana gelmiştir. Araştırma grubunun yaş ortalaması 15.82’dir. Veri toplama araçları olarak “Akıllı Telefon Bağımlılığı Ölçeği – Kısa Versiyonu - Şata ve Karip (2017)”, “Duygu Düzenleme Ölçeği - Ulaşan Özgüle ve Sümer (2017)”, “Çocuk ve Genç Psikolojik Sağlamlık Ölçeği - Arslan (2015)”, “Ergenler İçin Kısa Okulda Öznel İyi Oluş Ölçeği - Özdemir ve Sağkal (2016)” ve “Kişisel Bilgi Formu” kullanılmıştır. Araştırma verileri hiyerarşik regresyon analiz yöntemi ile analiz edilmiştir. Araştırma sonucunda; duygu düzenleme, psikolojik sağlamlık ve okulda öznel iyi oluş değişkenlerinin akıllı telefon bağımlılığını anlamlı düzeyde yordadığı belirlenmiştir.
Anniversary of the scientist: to the 60th anniversary of Corresponding Member of the Russian Academy of Sciences Andrey Nikolaevich Belskikh
Authors: Kryukov Evgeniy V. , Ivchenko Evgeniy V. , Ovchinnikov Dmitrii V.
Published: April 2022

On March 13, 2022, the prominent Russian scientist, specialist in extracorporeal hemocorrection, intensive therapy, and nephrology, Corresponding Member of the Russian Academy of Sciences, Doctor of Medical Sciences, Professor, Major General of medical service in the reserve, Andrey Nikolayevich Belskikh, turned 60. Andrey Nikolayevich spent almost 40 years at the Military Medical Academy, having worked his way up from the cadet and the adjunct to the head of the Academy. For almost two decades he headed the clinical center of extracorporeal detoxification and started his scientific career, defended his doctoral thesis, and received the academic rank of a professor. His research opened a new page in the study of previously unknown fundamental regularities of hemorheological blood changes in hypoxia of different genesis, fundamental mechanisms of etiology, and pathogenesis of critical states formation in intensive medicine. During his 6 years as the head of the Military Medical Academy in a difficult time, Andrey Nikolayevich has done a lot. He organized the training of specialists with secondary medical education at the new faculty, and trained doctors in the specialties of preventive medicine, dentistry, and pharmacy. A simulation training center, one of the first and the best in the country, has been created. New departments of nephrology and efferent therapy and general dentistry were added to the Academy staff. Large-scale reconstruction and re-equipment of the Academy were started. The concept of a multidisciplinary clinic, which was ceremonially opened by the President of the Russian Federation, V.V. Putin, was developed, as well as the clinic. The work of A.N. Belskikh was marked with the Order of Honor and the honorary title Honored Physician of the Russian Federation. After retirement from military service, Andrei Nikolaevich Belskikh headed the department of nephrology and efferent therapy, where he continued his successful research and scientific, pedagogical, and medical staff training.
Innovative technologies in the diagnosis and safe surgical treatment of thyroid diseases
Authors: Romashchenko Pavel N. , Maistrenko Nikolaj A. , Krivolapov Denis S. , Simonova Maria S.
Published: April 2022

This study clarified the results of using innovative technologies in the diagnosis and surgical treatment of patients with thyroid diseases by evaluating the role of modern diagnostic methods and effectiveness of minimally invasive thyroid surgery. The results of a comprehensive examination and treatment of 332 patients with thyroid diseases, who were examined using modern diagnostic methods and underwent conventional and various minimally invasive approaches, were analyzed. The sensitivity, specificity, accuracy, and positive and negative predictive values of multiparametric neck ultrasonography, 99mTc-MIBI thyroid scintigraphy, fine-needle cytology, and molecular testing of thyroid nodules were compared. The minimally invasive procedure was performed in 70.4% of the patients. Postoperative complications were found in 4.9% of the patients who underwent surgery, functional dysphonia in 0.9%, and transitory hypoparathyroidism in 2.4%. The use of the main criteria that determine the choice of a rational minimally invasive surgery, such as the nodule size and thyroid volume, hyperfunctioning thyroid, clinical thyroiditis, substernal extension, extrathyroid extension, and necessity of implementation of central and lateral neck dissection due to lymph node metastases, avoids the conversion of access to the traditional approach, prevents damage to the recurrent laryngeal nerve with the development of transitory or permanent recurrent laryngeal nerve palsy, and minimizes injury to the parathyroid glands with the development of isolated cases of transient hypoparathyroidism. Therefore, results of the multiparametric analysis of the examination and surgical treatment outcomes of patients with thyroid diseases show the feasibility of using innovative technologies in their diagnosis and surgical treatment. Modern examination methods allow us to determine with great accuracy the morphological form of thyroid disease and choose a rational volume and surgical intervention. In this study, minimally invasive procedures are optimal and safe in the surgical treatment of this category of patients.
Alphaviruses: a modern view on the problem
Authors: Stepanov Aleksandr V. , Yudnikov Ilya V. , Kvardakov Aleksandr V.
Published: April 2022

At present, infectious diseases of alphaviral etiology remain relevant. The study examined the characteristics of alphaviruses, including the present knowledge of the structure and replication of the virion; prevalence of epidemiologically significant species and potential distribution areas of some alphaviruses; pathogenesis and clinical presentation of causative diseases, diagnosis, prevention, and treatment; and their possible use as pathogenic biological agents. Sixteen strains of alphaviruses are hazardous to human health, and some of them can disrupt human activities. Areas with alphaviruses are characterized by specific ecological conditions, presence of vectors, and susceptible hosts. Alphaviruses are predominantly distributed in equatorial and subequatorial belts. Some alphaviruses have been reported in the Russian Federation. The natural foci of alphaviruses are reportedly altered because of the expansion of their existing localizations, including the Russian territory. To predict the occurrence of alphavirus outbreaks, it is necessary to monitor pathogenic populations for mutations that can significantly increase their pathogenicity and virulence. Most alphaviruses, including those registered in Russia, do not have specific products for diagnostics, prevention, and treatment. Meanwhile, alphaviral diseases have great militaryepidemiological significance, as they can cause natural focal morbidity in certain regions of the world and injury to the civilian population and service personnel following their use as pathogenic biological agents.
Features and significance of the early bronchodilatation effect of the first dose of a long-acting bronchodilator alone and in fixed combination in the treatment of chronic obstructive pulmonary disease
Authors: Sharova Natalia V. , Cherkashin Dmitriy V. , Grishayev Sergey L. , Efimov Semen V. , Kharitonov Mikhail A. , Turdialieva Sayera A.
Published: April 2022

The early bronchodilatory effects of the first dose of long-acting anticholinergics (glycopyrronium and tiotropium) were compared with those of a fixed double combination of long-acting bronchodilators of various classes (indacaterol/glycopyrronium) in patients with stable chronic obstructive pulmonary disease. The possibility of using the results of an early bronchodilatory response to predict their effectiveness in the basic therapy of chronic obstructive pulmonary disease is evaluated. A total of 176 patients with chronic obstructive pulmonary disease were examined. The patients were randomized into three groups. The first group (n = 66) took glycopyrronium, the second group (n = 60) received a combination of indacaterol/glycopyrronium, and the third group (n = 50, control) took tiotropium. Broncholytic tests with the listed drugs were evaluated. The early bronchodilatory effect of the first dose of 110/50 mcg indacaterol/glycopyrronium was manifested by significant bronchodilation (p 0.001) from 30 min, reached its maximum value 60 min after drug intake, and persisted after a 28-day course of treatment. The combination of indacaterol/glycopyrronium provided rapid and prolonged bronchodilation in patients with stable chronic obstructive pulmonary disease, demonstrating advantages over the isolated use of glycopyrronium and tiotropium. Maximization of bronchodilation by the sequential use of glycopyrronium and salbutamol leads to an increase in the volume of forced exhalation in the first second on the 90th min, comparable with the results of indacaterol/glycopyrronium on the 60th min after drug intake, which indicates the clinical feasibility of maximizing bronchodilation with drugs both separately and in combination. Based on a direct positive correlation between the initial value of the forced expiratory volume in the first second and the value on day 28 of indacaterol/glycopyrronium therapy, an equation for predicting the individual effectiveness of the drug during treatment is derived.
The skeleton of the giant Jacob Lolly is a unique “brand” of the department of normal anatomy
Authors: Gaivoronsky Ivan V. , Tvardovskaya Marina V. , Solovyev Kirill V. , Kirillova Maria P. , Spirina Tatyana S. , Vinogradov Stas V. , Semenova Anastasia A.
Published: April 2022

The paper presents the history of the appearance of the legendary skeleton of the giant Jacob Lolli in the museum collection of the Department of Normal Anatomy of the Military medical Academy. Research has been conducted on archival documents, including old magazines, newspapers, monographs, and minutes of the Academy Conference meetings stored in the Russian National Library, as well as the catalog and card index of the fundamental museum of the department. Data at the time of making the giant skeleton given in the catalog of the fundamental museum and literary sources of the 19th century were quite different and refer to the period from 1814 to 1818. Probably, the giants corpse was taken to the Department of Anatomy and Physiology of the Imperial MedicalSurgical Academy to establish the cause of death. After a while, the skeleton was presented to the Academy Conference as a rare museum exhibit and presented to its president, Jacov Willie, who returned the skeleton to the department. From 1818 to 1824, the skeleton temporarily left the walls of the academy and was examined by I.V. Buyalsky in the home museum. After the scientific work, the skeleton was returned to the department; as a result of the research conducted by I.V. Buyalsky in 1847, the article Measure of the skeleton and the weight of the bones of the giant Jacob Lolly, was the only published scientific work on the skeleton of a giant. The measurements were translated into the modern system of units. A brief description of the giants skull as a vivid example of typical changes in acromegaly was made a hundred years later by A.P. Bystrov, an employee of the department, in the book, Past, present, future of man. Two hundred years after its construction, the giants skeleton needed restoration, including delicate cleaning, restoration of destroyed fragments, and replacement of the material to imitate the cartilaginous components of the skeleton. The restorers work process is described, and the result of their activity is presented.
Russian pharmacovigilance: ways to improve efficiency
Authors: Taube Alexandra A. , Evko Irina Y. , Sinitova Svetlana V. , Krasheninnikov Anatoly E. , Zhuravleva Marina V. , Romanov Boris K. , Alyautdin Renad N.
Published: April 2022

The paper presents the results of a survey of pharmacovigilance specialists awareness of the regulation of reporting on adverse drug reactions, self-assessment of their competencies and readiness for distance learning, creation of a generalized portrait of a pharmacovigilance specialist to create mechanisms for improving pharmacovigilance activities, and continuing education of pharmacovigilance specialists. The results of the correlation analysis of the knowledge of pharmacovigilance specialists with their self-assessment of their position are reflected. Information-analytical and sociological (survey) methods and descriptive statistics were used. A questionnaire consisting of 31 items was developed for the survey. The first part of the questionnaire consisted of general questions, such as on education, work experience in the pharmaceutical field and pharmacovigilance, and position held. The second part focused on the structure of pharmacovigilance in the organization of holders of the registration certificate. The third part consisted of 17 items aimed at identifying the level of knowledge concerning the immediate daily activities in pharmacovigilance and knowledge of the legislative framework. The final element was a question about the attitude to distance learning. Specialists working in the field of pharmacovigilance at enterprises and persons authorized for pharmacovigilance objectively assessed their practical knowledge and skills in the field of drug safety. Moreover, 42 (72%) respondents believe that they do not need to update their knowledge on pharmacovigilance, whereas 51 (87%) people successfully passed the proposed survey on knowledge of current legislation. Employees of senior positions showed higher knowledge in the field of pharmacovigilance. Specialists and senior pharmacovigilance specialists need to increase their level of professional knowledge, and they are aware of the need for further training.
Cardiovascular complications in patients after coronavirus DISEASE-2019
Authors: Mirzoev Nikita T. , Kutelev Gennady G. , Pugachev Maxim I. , Kireeva Elena B.
Published: April 2022

The data of the modern literature describing the long-term consequences of infection of the body with SARS-CoV-2 on the cardiovascular system in the framework of postcovid syndrome are analyzed. To date, postcovid syndrome refers to a condition in which symptoms continue to persist for more than 12 weeks from the moment of diagnosis of COVID-19. Various complaints of patients after undergoing a new coronavirus infection are described, the distinguishing feature of which is their versatility, where cardiovascular manifestations are assigned one of the leading roles. Postural orthostatic tachycardia syndrome, cardiac arrhythmia and conduction disorders are considered. The role of SARS-CoV-2 in the formation of de novo and decompensation of pre-existing cardiovascular diseases has been demonstrated. The possibility of developing heart failure in patients with COVID-19 as an outcome of inflammation of the heart muscle is shown. Particular attention is paid to the analysis of the incidence of myocarditis after 3 months or more from the diagnosis of COVID-19, as well as thrombotic complications, in the genesis of which the main role belongs to the formation of endothelial dysfunction resulting from the interaction of SARS-CoV-2 with vascular endothelial cells. The autoimmune component of the pathogenesis of damage to the cardiovascular system as a result of the formation of endothelial dysfunction in COVID-19 is also considered. The authors present a laboratory-instrumental algorithm for determining cardiovascular complications in people who have undergone COVID-19, including the determination of the N-terminal fragment of the brain natriuretic peptide B-type prohormone, the level of anticardial antibodies, electrocardiography, echocardiography, as well as magnetic resonance imaging of the heart with contrast.
Genetic polymorphisms of catalase (rs7943316), glutathione peroxidase-1 (rs1050450), and transferrin (rs8177178) in keratoconus on a limited group of Russian patients
Authors: Solovev Alexey I. , Churashov Sergey V. , Kulikov Alexey N. , Buleev Adrian V. , Krutikova Anna A. , Arukov Artem R. , Kravtsov Viacheslav Y.
Published: April 2022

A pilot study of the association of single nucleotide polymorphisms in catalase (rs7943316), glutathione peroxidase-1 (rs1050450), and transferrin (rs8177178) genes with the risk of keratoconus development was conducted in a sample of Russian patients. Genotyping was performed by analyzing the polymorphism of the lengths of restriction fragments using a polymerase chain reaction. Venous blood samples from 25 patients with keratoconus treated at the Ophthalmology Clinic of the Kirov Military medical Academy in 2019 and 2020 were examined. The control group included 20 patients who had no clinical signs of keratoconus. The effect of the single nucleotide polymorphism rs7943316 of the catalase gene on the risk of keratoconus development has not been established. The T allele of the glutathione peroxidase-1 gene containing the rs1050450 polymorphism slightly increases the risk of keratoconus compared with the C allele (odds ratio = 1.91; 95% confidence interval = 0.754.85; p = 0.17). A moderate association of the A allele of the transferrin gene containing rs8177178 polymorphism with the occurrence of keratoconus and an increase in the incidence of the disease associated with the AG genotype was revealed (odds ratio = 5.67; 95% confidence interval = 1.0730; p = 0.12). Thus, when examining a limited sample of Russian patients with keratoconus, it was not possible to identify a link between the disease and single nucleotide polymorphisms of catalase rs7943316 and glutathione peroxidase-1 rs1050450. The relationship between the polymorphism of the transferrin rs8177178 gene (allele A and genotype AG) and the risk of keratoconus development was weak and not significant. Thus, expanding the study sample and further studying the polymorphisms of the transferrin gene that affect the structure of the enzyme and reduce the effectiveness of antioxidant protection of the cornea were recommended.
Features of treatment of ureteral injuries
Authors: Shanava Gocha S. , Mosoyan Michail S. , Protoshchak Vladimir V. , Soroka Igor V. , Nalivaiko Anastasia D. , Putrenok Dmitriy G. , Orlov Dmytriy N.
Published: April 2022

Choosing the optimal techniques for the treatment of ureteral injuries is necessary. Damage to the ureter accounts for 3% of cases of injuries of the genitourinary system. More than 70% of iatrogenic ureteric injuries are not detected during surgery. Approximately 75%80% of ureterotraumas are due to iatrogenic causes, of which 65%82% are due to gynecological surgeries. Mechanical injuries of the ureter are much less common than iatrogenic ones. Gunshot and stab wounds of the ureter prevail among mechanical injuries. Thirty-one patients who were treated at the I.I. Janelidze Research Institute of Emergency Medicine with various ureteral injuries from 2003 to 2019 were examined. Patients were divided into three groups according to the time of detection of ureteral injury. Group 1 included patients with ureteral injuries identified during surgery, group 2 included those with ureteral injuries diagnosed within 72 h, and group 3 consisted of patients with ureteral injures detected 72 h later. The choice of treatment techniques for ureterotrauma relied on the general condition of the patient, severity and level of damage to the ureter, timing of its diagnosis, and nature of the complications. On intraoperative detection of ureterotrauma in patients with a stable condition, reconstructive surgery of the ureter should be performed immediately to ensure the passage of urine from the upper urinary tract. If ureterotrauma is diagnosed before 72 h and there are no inflammatory complications, reconstructive ureteral surgery is also appropriate. If an infectious and inflammatory process develops, a staged operation is necessary to drain the upper urinary tract and relieve the developed posttraumatic complications. When ureterotrauma is diagnosed 72 h later, a staged operation is performed to eliminate complications and drainage of the upper urinary tract. Reconstructive surgery is performed not earlier than after 2 months.
On the consciousness of personality in a paranoid
Authors: Rudnev V. I.
Published: April 2022

In the Saratov psychiatric hospital for 20 years there has been a patient H, A. V-ov, a paranoid person with a university education, a former teacher of a gymnasium and a pro-gymnasium. Throughout his stay in the hospital, he expresses delusions of persecution and delusions of grandeur, suffers from auditory hallucinations.
A device for photographing human speech outside the room where the speaker is and without paying any attention to this process
Authors: Spirtov I. N.
Published: April 2022

It is possible to do without explaining the importance and desirability of phonography of human speech in various manifestations of social life and in scientific research, especially psychological and psychopathological; such a clarification would be a repetition of what has already been expressed many times at different times and has behind it a general recognition. This circumstance eliminates the need to prove the appropriateness of any attempt in one way or another to make phonography even more accurate or convenient in the sense of not embarrassing the person whose speech is recorded on the phonograph.
Paroxysmal syndromes in patients with discirculation in vertebral-basilar system
Authors: Eninya G. I. , Zagoryanskaya G. V.
Published: April 2022

As many as 450 patients with vertebral-basilar discirculations accompanied by attacks: syncopal, diencephalic, amnestic, sudden fall are examined using dopplerography correlated with other methods. The dependence of these states on arterial hypotension, extravasal stenoses, anomalies of vessels and vertebrae, extravasal commissures is established.
Kurumsal Politik Aktivizm ve İtibar Riskleri: Medya Yansımalarıyla Starbucks Örneği
Authors: SAĞLAM Bayram Bilge , ERTÜRK Egemen
Published: April 2022

Kurumsal politik aktivizm (KPA), toplumun çoğunluğu veya bir kısmını yakından ilgilendiren politik konulara yönelik olarak işletmelerin tutum belirlemesi ve bu doğrultuda faaliyetler gerçekleştirmesi olarak tanımlanabilir. Alışılagelmiş kurumsal sosyal sorumluluk faaliyetlerine kıyasla KPA faaliyetleri, odağına aldığı meselelere bağlı olarak işletmeler için itibar risklerini de beraberinde getirmektedir. Değişen tüketici beklentileri ve işletmelerin etki alanlarının genişlemesine bağlı olarak yeniden şekillenen toplum-işletme ilişkisi dinamikleri, işletmeleri bu faaliyetleri hayata geçirmeden önce daha itinalı karar verme süreci gözetmeye zorlamaktadır. İşletme itibarına ilişkin olumsuz sonuçlanmış bir KPA örneği olarak Starbucks’ın Amerika Birleşik Devletleri’nde yaşanan ırksal gerilimden yola çıkarak hazırladığı Race Together kampanyasını ele alan bu çalışmada, itibar kaybına sebebiyet veren unsurların derinlemesine incelenmesi amaçlanmıştır. Medya yansımaları incelenerek elde edilen bulgular; “kampanyadaki samimiyet eksikliği”, “işletme değerleriyle tutarsızlık”, “işletme-dava uyumsuzluğu ve kampanya fikrinin uygulanabilirliğine dair problemler” ve “kampanya amaç ve uygulama uyumsuzluğu” gerekçelerinin itibar kaybında önemli rol oynadığını göstermektedir. Beraberinde getirdiği tüm itibar risklerine karşın, KPA faaliyetlerini bütünüyle zararlı veya yararsız faaliyetler olarak değerlendirmek mümkün değildir. Starbucks Race Together kampanyasından yola çıkarak ortaya konmuş olan araştırma bulguları, toplumsal sorunların çözümünde rol üstlenmek isteyen işletmelere kampanya tasarımı ve yönetim iletişimi adına dikkat edilmesi gereken unsurlara ilişkin önemli çıkarımlar sunmaktadır.
Percepciones y experiencias de los profesionales de la salud sobre la aplicación de la norma de manejo y tratamiento de la anemia en menores de tres años durante la pandemia de la COVID-19
Authors: Delgado-Pérez Doris , Aparco Juan Pablo , Espinoza-Bernardo Sissy , Quintana-Salinas Margot
Published: April 2022

Objetivos. Comprender las percepciones y experiencias de los profesionales de la salud sobre la aplicación de la directiva para el manejo y tratamiento de anemia en niños menores de tres años, durante la pandemia de la COVID- 19 en Lima Metropolitana, año 2020. Materiales y métodos. Estudio de diseño fenomenológico. Se realizaron entrevistas semiestructuradas individuales a profesionales de salud: médicos, enfermeras y nutricionistas que trabajaban en el primer nivel de atención en el Ministerio de Salud de Lima, Perú. Las entrevistas se llevaron a cabo en forma virtual. Todos laboraban en forma presencial en servicios de atención a niños menores de tres años. El análisis de datos fue temático, para las codificaciones se utilizó el software NVivo. Resultados. Se realizaron 33 entrevistas a profesionales de la salud, entre noviembre de 2020 a enero de 2021. Surgieron cuatro temas emergentes sobre la norma: su factibilidad, imperfecciones percibidas, los desafíos para implementarla y las perspectivas de mejora. Los profesionales entrevistados percibieron que la norma era factible de ejecutarla, pero presentaba vacíos en las indicaciones que deberían estar más explícitos los aspectos del manejo y tratamiento de la anemia. A pesar de ello dieron a conocer sus desafíos y expectativas de mejora. Conclusiones. Los encuestados percibieron que fue factible utilizar la norma y destacaron sus experiencias para lograr superar las dificultades pese a encontrar vacíos en la normativa para el manejo y tratamiento de la anemia.
Intervención educativa basada en estilos de vida para incrementar la proporción de adolescentes libres de componentes del síndrome metabólico en una región altoandina del Perú
Authors: García Flores Segunda Aydeé , Ninatanta-Ortiz Juana Aurelia , Abanto Villar Martha Vicenta , Pérez Cieza Katia Maribel , Chávez Farro Rosa Ricardina , Palacios Sánchez Sara Elizabeth , Romaní Romaní Franco Ronald
Published: April 2022

Objetivo: Estimar el efecto de una intervención educativa basada en nutrición y estilos de vida saludables para incrementar la proporción de adolescentes libres de componentes del síndrome metabólico. Materiales y métodos: Se realizó un estudio preexperimental en una muestra representativa de adolescentes de dos escuelas de un distrito altoandino del Perú (ciudad de Cajamarca); 388 estudiantes completaron la intervención, así como la medición basal y la posintervención. La intervención tuvo nueve ejes temáticos, cada uno fue desarrollado en una sesión educativa de 45 min cada dos semanas. Se usó los criterios del National Cholesterol Education Program Expert Panel and Adult Treatment Panel III para el síndrome metabólico. Se realizó la comparación de proporciones pareadas (prueba de McNemar) para determinar el impacto de la intervención. Resultados: En la medición basal, el 20,4% (IC95%: 16,2 a 24,5) no tenía componentes de SM, posintervención dicha proporción se incrementó a 32,5% (IC95%: 27,7 a 37,3), la diferencia de proporciones fue 12,1% (IC95%: 7,5 a 16,8; p0,001). La prevalencia de síndrome metabólico fue 4,6% (IC95%: 2,4 a 6,9) basalmente; posintervención fue 2,3% (IC95%: 0,7 a 3,9). La diferencia de proporciones fue 2,3%, (IC95%: 0,3 a 3,2; p=0,022). Entre los componentes, la mayor reducción fue en la proporción de hipertrigliceridemia (diferencia de proporciones: 21,9%, IC95%: 16,9 a 26,9; p0,001), también se observó una reducción significativa de la hipertensión arterial (diferencia de proporciones: 3,1%, IC95%: 0,6 a 5,6; p=0,025). En los demás componentes no hubo diferencias significativas. Conclusiones: La intervención educativa incrementó en un 59,3% la proporción de estudiantes libres de algún componente del síndrome metabólico.
Validation of the Probabilistic Seismic Hazard Assessment by the Taiwan Earthquake Model through Comparison with Strong Ground Motion Observations
Authors: Gao Jia-Cian , Tseng Yi-Hsuan , Chan Chung-Han
Published: April 2022

To validate the probabilistic hazard assessment proposed by the Taiwan Earthquake Model (TEM), we compared it with the strong ground motion observations. We accessed the Taiwan Strong Motion Instrumentation Program (TSMIP) database and reported the maximum ground shaking of each strong-motion station. Comparing the TSMIP observations and the TEM hazard model reveals similar spatial patterns. However, some records indicate significantly higher shaking levels than the model does due to the occurrence of some large events, for example, the 1999 Mw 7.6 Chi-Chi earthquake. Such discrepancies cannot be explained by model parameter uncertainties but by unexpected events in the given short observation period. We have confirmed that, although each seismogenic structure in Taiwan is unlikely to rupture within a short period, the summarized earthquake potentials from all of the structures are significant. In addition, we discuss the impacts of some model parameters, including epistemic uncertainties of source parameters, truncation of standard deviation for ground-motion prediction equations, the Gutenberg–Richter law for area source, and the time-dependent seismicity rate model. The outcomes of this study provide not only crucial information for urban planning on a city scale and building code legislation on a national scale but also suggestions for the next generation of probabilistic seismic hazard assessment for Taiwan as well as other regions.
La legitimidad del Fondo de apoyo a la solvencia de empresas estratégicas para la economía española en tiempos de COVID-19: La sentencia del Tribunal General Ryanair DAC/Comisión
Authors: Di Comite Valeria
Published: April 2022

En la sentencia de 19 de mayo de 2021, asunto T-628/20, el Tribunal General decide que es legitima la decisión de la Comisión europea que autoriza el régimen de ayudas español dirigido a realizar un Fondo de apoyo para la recapitalización del las empresas sistémicas y estratégicas para la economía nacional. La ayuda se justifica debido a la excepcionalidad de la situación de emergencia sanitaria, económica y social causada por la pandemia da COVID-19. Este Comentario se detiene, por una parte, en la interpretación del Tribunal relativa al concepto de «régimen de ayudas» y, por la otra, en el examen de la excepción establecida en la letra b) del apartado 2 del Artículo 107 TFUE a la luz del «marco temporal» de marzo de 2020. Resulta interesante examinar las motivaciones de la sentencia que, en esta situación de emergencia, según el Tribunal General justifican la concesión de un «régimen de ayudas» dirigido a la recapitalización de las solas empresas que tienen su domicilio social y sus principales centros de trabajos en el Estado Miembro concedente, cómo excepción del fundamental principio de no discriminación por razón de nacionalidad.
La inmunidad de jurisdicción de los gobernadores de los bancos centrales nacionales a la luz del derecho de la UE: La sentencia del Tribunal de Justicia LR Ģenerālprokuratūras
Authors: Valles Cavia José Antonio
Published: April 2022

La Gran Sala del Tribunal de Justicia de la Unión Europea ha dictado sentencia sobre la cuestión prejudicial planteada en diciembre de 2019 por el Tribunal de Primera Instancia de Riga al objeto de interpretar los arts. 11.a), 17 y 22.1 del Protocolo nº 7 sobre los privilegios y las inmunidades de la Unión Europea. En ella se acomete el análisis de la posibilidad de que los gobernadores de los bancos centrales nacionales puedan beneficiarse de la inmunidad de jurisdicción cuando realizan actos de carácter oficial como miembros de un órgano de la Unión, al tiempo que se emprende una revisión en profundidad de cuestiones esenciales tales como el objeto y alcance de esa protección, el papel que juega el Banco Central Europeo a la hora de determinar la suspensión o no de la inmunidad cuando se puedan ver afectados intereses de la Unión, e incluso si la inmunidad alcanza también a las diligencias penales o a las pruebas obtenidas por los órganos nacionales competentes.
DILATATION OF IATROGENIC VAGINAL STENOSIS WITH AN ABSORBABLE OXIDIZED REGENERATED CELLULOSE
Authors: Elçi Atılgan Adeviye , Acar Ali , Ercan Fedi , Altuntaş Şükriye Leyla , Purut Yunus Emre
Published: April 2022

OBJECTIVE: Iatrogenic vaginal stenosis adversely affects the sexual life of couples. The definitive treatment of this condition is possible by redilatation of vagina. This study aims to investigate the outcomes of vaginal dilatation procedure performed using an absorbable oxidized regenerated cellulose.MATERIAL AND METHODS: 29 patients who could not have intercourse due to Iatrogenic vaginal stenosis underwent vagina enlargement surgery using an absorbable oxidized regenerated cellulose in the period of April 2014 to August 2020. The results were analysed with the help of the standard ‘Patient Global Impression of Improvement Scale (PGI-I) which evaluates patient satisfaction in particular.RESULTS: The mean follow-up period was 16 monts (14 - 24 months). No major perioperative complication was detected except from perianal hemotoma treated with antibiotics and drainage in a case. At 6th month follow up visit, 27 patients reported pain free sexual intercourse. Two patients needed re-dilatation 4 and 6 months later respectively.Based on the scores of patients as “much better ‘’and ‘’very much better” on the PGI-I scale, satisfaction rate was 93% at 6th month follow up visit.CONCLUSIONS: Vaginal dilatation surgery with absorbable oxidized regenerated cellulose seems to be a safe and effective procedure with positive anatomical and functional results. However, many comparative studies a