bluuebunny/crossref_metadata_2025 huggingface dataset:
KESESUAIAN PERTIMBANGAN MAHKAMAH AGUNG DALAM KASUS PENYALAHGUNAAN NARKOTIKA BERDASARKAN PASAL 253 AYAT (1) KUHAP
Authors: Abhista Muhammad Ezar
Published: March 2023

Penulisan ini bertujuan untuk mengetahui kesesuaian pertimbangan Mahkamah Agung dalam mengabulkan pengajuan kasasi dengan Pasal 253 Ayat (1) KUHAP. Kasus tindak pidana penyalahgunaan narkotika di Martapura, Terdakwa oleh Penuntut Umum didakwa melakukan tindak pidana tanpa hak atau melawan hukum memiliki, menyimpan, menguasai narkotika. Pada Banding Pengadilan Tinggi Banjarmasin menyatakan terdakwa bersalah atas penyalahgunaan narkotika. Atas putusan tersebut, Penuntut Umum mengajukan kasasi terhadap Pengadilan Tinggi Banjarmasin yang menyatakan terdakwa bersalah atas penyalahgunaan narkotika sesuai ketentuan Pasal 253 ayat (1) KUHAP, bahwa: 1) Apakah benar suatu peraturan hukum tidak diterapkan atau diterapkan tidak sebagaimana mestinya. Pertimbangan Mahkamah Agung mengabulkan pengajuan kasasi oleh Penuntut Umum dapat dibenarkan karena Judex Facti salah dalam menerapkan hukum karena tidak mempertimbangkan dengan baik dan benar terhadap keterangan saksi-saksi dan keterangan Terdakwa sehingga putusannya menyatakan mengabulkan kasasi penuntut umum. Di persidangan terbukti fakta hukum bahwa benar terdakwa telah tanpa hak menguasai narkotika golongan 1 sesuai dengan Pasal 112 Undang – Undang Nomor 35 Tahun 2009 tentang Narkotika.

Kata Kunci: Kasasi; Penuntut Umum; Narkotika.

This writing aims to determine the suitability of the Supreme Court’s consideration in granting the cassation submission in accordance with Pasal 253 Ayat (1) KUHAP. The case of drug abuse in Martapura, the accused is charged by the Prosecutor of committing a crime without right or contrary to law to possess, store, and control drugs. An Appeal High Court of Banjarmasin, the accused was found guilty of drug abuse in accordance with Pasal 253 Ayat (1) KUHAP, that (1) Whether a legal rule is not applied or applied inappropriately. The consideration of the Supreme Court in granting the Prosecutor's cassation can be justified because the Judex Facti is wrong in applying the law because it does not properly consider the statement of the witnesses and the statement of the accused so that the decision is to grant the Prosecutor’s cassation. In the trial, it was proven that the legal fact that the accused did indeed possess a Class 1 drug without right in accordance with Pasal 112 Ayat (1) Undang – Undang Nomor 35 Tahun 2005 tentang Narkotika.

Keywords: Cassation, Prosecutor, Narcotic.
Study on Process Design Based on Language Analysis and Image Discrimination Using CNN Deep Learning
Authors: Hayashi Akio , Morimoto Yoshitaka
Published: March 2023

At present, machining with numerically controlled (NC) machine tools is mostly performed by NC programs generated by computer-aided design and computer-aided manufacturing (CAD/CAM) systems. However, even if the machining shape to be machined is the same, there are numerous machining processes involving a series of operations such as determining the machining area, machining order, and machining conditions. These are entrusted to the user, and automation is difficult. In addition, these tasks depend on the experience and know-how of skilled engineers, and it is very difficult to convert them into algorithms and reflect them in the creation of NC programs. Therefore, in this study, artificial intelligence (AI) was used for the process design of multi-tasking machine tools, with the goal of determining and automating the process design using shape examples. We propose a shape recognition method that includes image analysis by AI. This image analysis makes it possible to determine the characteristics of the machining shape, and the machining operator can easily judge the machining process based on the CAD model. Furthermore, because there are shapes that cannot be determined from image data alone, shape features are also extracted from the STEP file of the CAD model. A language analysis of the STEP file can find the characteristic components and their numerical information to determine the coordinates of the shape features. By combining image analysis and language analysis, the method can easily judge the process based on the information in the CAD model. Finally, using the generated learning model and analysis program, we conducted a test to determine whether a multitasking machine tool is necessary for machining.
Automated Generation of Product Assembly Order Based on Geometric Constraints Between Parts
Authors: Nishida Isamu , Sawada Hayato , Shirase Keiichi
Published: March 2023

This study proposes a method for automating the determination of assembly order by automating the derivation of the necessary connection relationships between the parts. The proposed method minimizes the information required for the initial conditions and automatically determines the feasible assembly orders. As a general rule, based on the assumption that the assembly order for a product is the reverse of the disassembly order, once the disassembly order is derived based on the 3D CAD model and the connection relationships between the parts, the assembly order can be determined. Until now, however, the relationships between the parts are decided manually by the attendant engineers, thus, hindering the full automation of the determination of the assembly order. To achieve full automation realistically, the connection relationships between the parts should be derived automatically from the 3D CAD model, for which this study proposes an efficient method. The components were extracted from the 3D CAD model, and the bolts were identified. The connection relationships between the parts were derived from the interference conditions determined while moving each part minutely. An association chart diagram was created from the obtained connection relationships, from which multiple assembly order candidates could be derived.
Meaning Shift of Exclusive Religious Text in Abyan al-Hawāij by K.H. Ahmad Rifa’i
Authors: Maskhur Maskhur , Shabir Muslich , Syukur Fatah , Muhtador Moh.
Published: March 2023

This article examines the shift in the meaning of religious texts that transform from exclusive to inclusive in the book Abyan al-Hawāij by K.H. Ahmad Rifa’i. This reinterpretation of the text is given that the conflicts that occurred between the Rifa’iyah group and non-Rifa’iyah residents were mostly caused by the Rifa’iyah group’s textual reading of religious texts that were exclusive. This article reviews exclusive religious texts by showing their historicity (historical function), meaning development (meaning function), and implicative function (implicative function) in order to show a more proportional new meaning. The approach used in this study is hermeneutics of Gracia, critical discourse analysis of Fairclough, and intertextual of Kristeva. The analysis is focused on looking back at the structure of the text (textual analysis), the discourse built by the author (discursive analysis), and the socio-cultural practices surrounding the text. Hermeneutically, the text is then seen in terms of its historical function, the function of developing its meaning, and the function of its implications within the framework of the cultural function of the text. The results of the research show that the exclusive religious text in Abyan al-Hawāij is an oppositional and confrontational text built by the author as a response to the Dutch colonial socio-cultural and political realities in the archipelago at that time. Therefore, reading these texts must also see the discourse of the text. These texts actually have many meanings (multi-vocality). In principle, these meanings are equally acceptable in line with their respective discourses. Reading the exclusive text in Abyan al-Hawāij in the current era of religious tolerance and harmony requires understanding the historicity of the text so as not to get stuck in an exclusive understanding of religion.
From Heart to Heart: An Empirical-Synthesis of a Muslim’s Donation Cycle
Authors: Faza Firdan Thoriq , Indriani Astiwi
Published: March 2023

This research contributes to the theory of giving behavior from the perspective of Islamic religiosity by describing how an individual Muslim makes donations from the initial intention, manages their finances and savings, and impacts their intrinsic satisfaction and religious beliefs. Descriptive qualitative research was conducted with case studies to describe the dynamics of a series of decisions made by individuals based on their experience of giving donations. The analytical methodology uses a descriptive qualitative narrative type technique taken from in-depth interviews until the data sample is saturated by respondents in Semarang, Indonesia. Twelve respondents were selected based on their experience in donating, the amount of the donation and the variation in their ages. The study results show that individuals who have religious awareness will have a strong desire to help other people or their community because they comply with religious observance guidelines. In addition, donations are helpful because they can provide an experience of gratitude, intrinsic satifaction, creating a sense of security from evil to have a continuous donation cycle. This research produces a synthesis in a cycle model between religiosity, donation, and intrinsic satisfaction.
The Correlation Between Critical Thinking Skills with Student Metacognitive Skills in Ecosystem Material
Authors: Khairunnisa Hanifah , Azrai Eka Putri , Ristanto Rizhal Hendi
Published: March 2023

Critical thinking skills are the active thinking process by someone by analyzing information, questioning the truth by remembering old memories so that a conclusion is obtained. Critical thinking skills are influenced by student readiness factors in learning including planning, monitoring and evaluation. Therefore, students with low critical thinking skills need to improve thinking skills by planning the systematic learning through empowerment of metacognitive skills. This study aims to determine the correlation between critical thinking skills with the metacognitive skills on ecosystem material. This research was conducted at SMAN 13 Jakarta in year 2021/2022. The method used is a quantitative descriptive method with a correlation study. This research consists of two variables, namely critical thinking skills as independent variables and metacognitive skills as a dependent variable. The sample used was 135 students of class XI MIPA which had obtained the elected ecosystem material through the Simple Random Sampling technique. Data collection is done through survey techniques using critical thinking skills tests and metacognitive skills tests. Based on the results of the study obtained a correlation coefficient of 0, 346 in the correlation of critical thinking skills with student metacognitive skills on ecosystem material. The results of the analysis show that there is a positive correlation between critical thinking skills with student metacognitive skills on ecosystem material.

           
Development of Interdisciplinary Learning Based on The Integration of Science Technology Environment, Art, Society, And Language (STEASL) In Biology Learning
Authors: Kholid Idham , Supriyadi Supriyadi , Kholid Ridho
Published: March 2023

The 21st century has shifted the direction of education in many countries to move forward with an interdisciplinary paradigm. As a consequence, it also induces alteration in the design of learning in the class. This research aims to (1) develop a biology learning module based on Science, Technology, Environment Art, Society and Language integration in the scope of biology learning; (2) examine the appropriateness of such developed-module; (3) reveal students’ response toward such module. This development effort is necessary to elaborate a trend of modern interdisciplinary learning by constructing collaboration between Biology, English, and the other sciences. The essential topics provided in this module comprise the scientific method, biodiversity, the relation among humans, nature, art, and technology, etc. This research employs the method of Research and Development (R&D) by the design of 4D: define, design, develop and disseminate. The skills of the 21st century trained in this learning encompass communication skills, cooperation, time management, creative-critical thinking skill, and problem-solving. The instruments of this research are a sheet of validation expert, observation sheet, and questionnaire. Sources of data consist of learning experts, language experts, media expert, content expert, and 50 students. Data analysis uses an analytical, descriptive technique. The result of research shows: (1) Learning module based on  STEALS-integration is assessed as highly appropriate (average score of 93,25); (2) Students give positive responses to such developed module (average percentage of 87,75%). Thus, this module can comprehensively contribute to adding academic discourse on interdisciplinary learning and improvement of the 21st century’s skills for students. 
Stereological Measurement of the Volume of Medulla Oblongata in Young Adults from Magnetic Resonance Images using ImageJ Software
Authors: Mohamed Abdalrahim , Hamd Zuhal , Alorainy Amal , Gareeballah Awadia , Alhomida Basim , Elhussein Nagwan , Alshegri Haya , Mustafa Sahar , Albadri Sara , Ahmed Wegdan
Published: March 2023

Background: The aim of this study was to measure the volume of the medulla oblongata (MO) in young adult Sudanese from magnetic resonance images using ImageJ software. Methods and Results: The study included 36 (18 males and 18 females) young adult Sudanese with normal brain MRI. The MO volume was measured from a T1-weighted MRI in healthy young adult Sudanese using ImageJ software to determine the effect of age, sex, and body mass index (BMI) on the MO volume. The study found that the stereological volume of MO was 717.39±82.31 mm3 with significant differences between genders. The mean MO volume was greater in males than in females (769.2±54.2 mm3 and 665.7±73 mm3, respectively. P<0.001). There was an inverse, positive, moderately significant correlation between the age and MO volume (r=-0.341, P<0.05). In contrast, there was no significant correlation between BMI and MO volume (P>0.05) Conclusion: Our study detected a significant difference between genders in MO volume, which was greater in males than in females. There is no significant correlation between MO volume and BMI. The size of the MO in individuals with normal brain MRI decreased gradually, by increasing age, from 20 to 40 years.
Radiomorphometric Indicators, their Reliability in Detecting Early Signs of Osteoporosis in Menopausal Women
Authors: Shkodra-Brovina Merita
Published: March 2023

Background: The aim of this study was to evaluate the diagnostic value of panoramic radiography and the radiomorphometric indices in osteoporosis identification. Methods and Results: The research included 60 women (average age of 62,907,07 years) in the postmenopausal stage who were subjected to an assessment of bone density through the DEXA test and were divided into 2 groups based on the value of the DEXA test from the lumbar region (L1-L4): Main group (MG) included 30 women with osteoporosis (T-score<-2.5) and Comparison group (CG) included 30 women without osteoporosis (T-score>-2.5). Panoramic radiography were used to assess the mandibular cortical index (MCI), mental index (MI), panoramic mandibular index (PMI) Based on the porosity level, Klemetti et al.(1994) has categorized MCI into three categories (C1, C2, and C3). MCI–C1, which represents the normal appearance of the lower jaw cortex without changes in bone quality, was found only in CG in 63.33%. MCI-C2 and MCI-C3 were found in 70% and 30% of cases, respectively, in MG. In CG, MCI-C2 was found in 36.67% of cases and MCI-C3 in 0% of cases. There was a significant difference between the two study groups in the distribution of MCI (P=0.000). MI below 3 mm was found in 19(63.33%) of cases in CG and 27(90.00%) in MG (OR=5.211, 95% CI: 1.278-21.237, P=0.0213). PMI below 0.3mm was found in 7(23.33%) of cases in CG and 19(63.33%) in MG (OR=5.675 95% CI: 1.841-17.494, P=0.0025). MCI sensitivity and specificity for osteoporosis were 70% (95% CI: 50.60%-85.27%) and 63.33% (95% CI: 43.86%-80.07%), respectively; PPV, NPV, and accuracy were 65.62% (95% CI: 53.03%-76.35%), 67.86% (95% CI: 53.41%-79.54%) and 66.67% (95% CI: 53.31%-78.31%), respectively. MI sensitivity and specificity at a cutoff point of 3 mm for osteoporosis were 90% (95% CI: 73.47%-97.89%) and 36.67% (95% CI: 19.93%-56.14%), respectively; PPV, NPV, and diagnostic accuracy were 58.70% (95% CI: 51.35%-65.67%), 78.57% (95% CI: 53.18%-92.21%) and 63.33% (95% CI: 49.90%-75.41%), respectively. PMI sensitivity and specificity at a cutoff point of 0.3 mm for osteoporosis were 63.33% (95% CI: 43.86%-80.07%) and 76.67% (95% CI: 57.72%-90.07%), respectively; PPV, NPV, and diagnostic accuracy were 73.08% (95% CI: 57.32%-84.58%), 67.65% (95% CI: 55.66%-77.69%) and 70.00% (95% CI: 56.79%-81.15%), respectively. Conclusion: PR can be a useful tool to identify early signs of osteoporosis by using the evaluation of radiomorphometric indices. MCI, MI, and PMI can be potential screening tools for initial BMD loss.
Immunofluorescence Analysis of Erythrocyte Membranes of Cervical Cancer Patients
Authors: Mamaeva Sargylana , Alekseev Vladislav , Nikolaeva Nadezhda , Krylova Tatyana , Gabysheva Aya , Pavlov Alexandr , Kononova Irina , Maksimov Georgy
Published: March 2023

Currently, cervical cancer (CC) is one of the most common oncological diseases. In this regard, it is necessary to develop new research methods for a more detailed study of the occurrence and development of the disease at the molecular and cellular levels, as well as to improve the effectiveness of treatment and form a deeper understanding of the causes of relapses. The aim of this work was to study nanoparticles localized on the erythrocyte membrane—presumably HPV 16, 18, before and after radiation therapy, in patients with cervical cancer (CC). To study the surface of red blood cells by the SEM method, venous blood samples from 17 patients with a confirmed diagnosis of CC were prepared in thin layers evenly applied to a dry, fat-free glass slide, which was dried at room temperature. To detect nanoparticles on the surface of erythrocytes by the immunofluorescence analysis, we developed a special protocol for preparing erythrocyte masses from patients diagnosed with CC. As a result of using a new method of sample preparation for immunofluorescence assay and using SEM, the hypothesis of the viral nature of nanoparticles localized on the surface of the blood erythrocytes of patients with CC was confirmed: Particles of HPV 16 and 18 are located on the cytoplasmic membrane of erythrocytes. Studies suggest that viruses attach to the erythrocyte membrane, which seems to influence the development of CC, its recurrence, and metastasis.
In vitro investigations of biological activities of Thymus willdenowii and Thymus atlanticus polyphenol-rich extracts
Authors: HAMZA Elbouny , BRAHİM Ouahzizi , KHALİD Sellam , CHAKİB Alem
Published: March 2023

Thyme species produce a wide variety of phenolic compounds including tannins, phenolic acids, and flavonoids. Thymus atlanticus (T. atlanticus) and Thymus willdenowii (T. willdenowii) are important thyme species in the southeast of Morocco, with numerous biological properties. The polyphenolic extracts of these two thyme species were obtained using ethanol through Soxhlet apparatus. Antioxidant (DPPH, FRAP, and TAC methods), antihemolytic (2,2'-Azobis(2-amidinopropane) dihydrochloride (AAPH) induced hemolysis test), hypolipidemic (3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase activity inhibition test), and anti-inflammatory (protein denaturation inhibition) effects of extracts were carried out using in vitro methods. The results showed that the polyphenolic extracts of these two species revealed important amounts of phenolic compounds. The contents of flavonoids were significant in the two species, while the contents of tannins and anthocyanin were very low. T. atlanticus showed an important antioxidant activity and a considerable antihemolytic effect in AAPH-induced hemolysis test (IC50 = 0.29 mg/mL), while T. willdenowii showed an important anti-inflammatory activity in heat-induced protein denaturation test (IC50 = 1.61 mg/mL). Moreover, both extracts at a dose of 20 µg/mL showed an important in vitro hypolipidemic activity by inhibiting HMG-CoA reductase activity (T. willdenowii: 51.16 %; T. atlanticus: 62.83 %). In conclusion, T. willdenowii and T. atlanticus extracts have considerable antioxidant, antihemolytic, hypolipidemic, and anti-inflammatory effects. The richness of these species in polyphenols gives them a large specter of biological properties, making them a valuable source of natural bioactive compounds that could prevent or treat various diseases.
Promising antioxidant activity of crude extract from Calliandra tweedii Benth
Authors: DOS SANTOS Kátia , NAGAİ Alice , PALACİOS Carmen , EVANGELİSTA Bruno , PRİANTE Carlos , ZAMBAN Débora , FURLAN Claudia
Published: March 2023

The interest in medicinal plants encourages new research studies on plant extracts, as they are sources for treatments in medicine, agriculture, and veterinary. Calliandra tweedii is a native Brazilian species with broad use in folk medicine. This study aimed to examine the leaf crude extract (CE) of C. tweedii and its methanolic (MP) and hexane (HP) phases concerning total phenolic compounds (TPC), proanthocyanidins (PRO), and flavonoid profile, and correlate it to their antioxidant activity (DPPH and FRAP). CE and MP revealed high contents of TPC, PRO and high antioxidant activity (DPPH and FRAP) in relation to HP. Contrarily, HP showed reduced antioxidant activity, according to the scarce phenolic constituents obtained from the partition. Five flavonols were detected by HPLC-UV-DAD, being quercitrin the major constituent. Also, one kaempferol derivate and a series of three quercetin derivates were detected. Strong positive correlations were observed between DPPH, FRAP, and phenolic compounds. These discoveries are important to highlight the promising antioxidant activity of CE of C. tweedii, which could contribute to the expansion of popular herbal medicines and new drug discovery.
Solution Methods for Nonlinear Ordinary Differential Equations Using Lie Symmetry Groups
Authors: Perera Disanayakage Hashan Sanjaya , Gallage Dilruk
Published: March 2023

For formulating mathematical models, engineering problems and physical problems, Nonlinear ordinary differential equations(NODEs) are used widely. Nevertheless, explicit solutions can be obtained for very few NODEs, due to lack of techniques to obtain explicit solutions. Therefore methods to obtain approximate solution for NODEs are used widely. Although symmetry groups of ordinary differential equations (ODEs) can be used to obtain exact solutions however, these techniques are not widely used. The purpose of this paper is to present applications of Lie symmetry groups to obtain exact solutions of NODEs . In this paper we connect different methods,theorems and definitions of Lie symmetry groups from different references and we solve first order and second order NODEs. In this analysis three different methods are used to obtain exact solutions of NODEs. Using applications of these symmetry methods, drawbacks and advantages of these different symmetry methods are discussed and some examples have been illustrated graphically. Focus is first placed on discussing about the notion of symmetry groups of the ODEs. Focus is then changed to apply them to find general solutions for NODEs under three different methods. First we find suitable change of variables that convert given first order NODE into variable separable form using these symmetry groups. As another method to find general solutions for first order NODEs, we find particular type of solution curves called invariant solution curves under Lie symmetry groups and we use these invariant solution curves to obtain the general solutions. We find general solutions for the second order NODEs by reducing their order to first order using Lie symmetry groups.
Basic Algorithms Quantum Cryptanalysis
Authors:   Saint Petersburg Electrotechnical University LETI, Petrenko Alexei , Petrenko Sergei ,   Saint Petersburg Electrotechnical University LETI
Published: March 2023

Purpose of the article: development of quantum algorithms for efficient solution of cryptanalysis problems of asymmetric encryption schemes (RSA, ElGamal) and digital signature (DSA, ECDSA or RSA-PSS), based on computationally difficult problems of factorization and discrete logarithm.Research methods: Methods of quantum cryptanalysis based on the algorithms of Shor, Grover, Simon, etc.Results: algorithms for solving problems of quantum cryptanalysis of two-key cryptography schemes in polynomial time.Practical relevance: consists in developing a solution for computationally difficult problems of factorization and discrete logarithm in polynomial time, taking into account the security of the discrete algorithm (DLP) and the discrete elliptic curve algorithm (ECDLP). The obtained scientific results formed the basis for the development of a special Software Development Kit, SDK for cryptanalysis “Kvant-K”. The Certificate of state registration of the computer program No. 2020665981 was received.
Legal Aspects of Modern Cybersecurity and Cybercrime Counteraction
Authors:   Gubkin Russian State University of Oil and Gas (National Research University), Kartskhiya Alexander , Makarenko Grigory ,   FBU SCLI
Published: March 2023

The article analyses contemporary legal aspects and current cybersecurity issues, cybercrime features of Rus- sian and foreign law of information and communication technologies. The research methods consist of comparative legal analysis of contemporary Russian and foreign legislation and law enforcement practice, as well as, a formal and logical study of a conceptual apparatus, content and struc- ture of the research object. The study results enable the authors to formulate the awareness of cybercrime legal content, that includes not only offenses committed by using computer technology, but other information and communication equipment and tools, including software either. The rapid spread of cybercrime, the emergence of new forms of organized crime using the global Internet, intended and well-organized cyber attacks on a critical infrastructure of states and private companies indicate the formation of a special area of crime - cybersecurity crime and information technol- ogy, which goes beyond a common insight of crime of information technology and communications. Therefore, the authors came to certain conclusions to conceptualize theoretical and methodological principles, develop the foundations of law and order of cybersecurity, clarify the conceptual apparatus and specifics of legal regulation of cybersecurity in public and private law, as well as the formation of a new line of criminology of cybercrime. The scientific novelty of the study consists of a conceptual justification of a cybercrime countering, as an ele- ment of national cybersecurity, as well as, the substantiation of a specific line of criminology - cybercriminology.
On the Construction and Analysis Features of Graphs of Interacting Objects in the Telegram-Channels Network
Authors:   Higher School of Economics, Chepovskiy Alexander
Published: March 2023

The purpose of the study:. search for a technique for constructing and analyzing a graph of interacting objects in the network of Telegram channels, including the calculation of psycholinguistic characteristics of texts. This tech- nique makes it possible to classify groups of channels and evaluate their informational impact on users.Method:. U , M , R -model is used to build a weighted graph during data import. Next, on the resulting graph,the Galaxies method is applied to reveal implicit intersecting communities. Psycholinguistic factors are calculated on the imported combined texts of communities to assess the channels thematic focus. Results:. the article presents a methodology for working with a network of Telegram channels in order to identify groups of channels that carry out information impact on users. A full cycle of actions is presented, starting from data import, using a model for constructing a graph of interacting objects for such networks, and ending with the calculation of psycholinguistic characteristics of texts for groups of channels. At the same time, the issue of the most effective selection of implicit communities in networks of Telegram channels is highlighted. An example of a network and a constructed weighted graph with markers calculated on texts, which are the most indicative for identifying the channels focus, is presented. The presented approach, by highlighting significant differences in the corresponding markers, makes it possible to identify channels that most actively carry out informational impact on users. The combination of an algorithmic approach and the use of psycholinguistic research represent the scien- tific novelty of this method. The results obtained make it possible, using the methods of computational linguistics in combination with the communities reveal methods, to evaluate different participants in such networks.
C-Section in Uncorrected Ventricular Septal Defect and Pulmonary Hypertension Management in Anesthesia Perspective
Authors:   Anesthesiology and Intensive Therapy, Faculty of Medicine, Sebelas Maret University, Solo Indonesia, Febrianti Rizki Fitria , Supraptomo Robertus Theodorus ,   Anesthesiology and Intensive Therapy, Faculty of Medicine, Sebelas Maret University, Solo Indonesia
Published: March 2023

Background: Pregnancy with cardiac defects and pulmonary hypertension happen 0.2% to 3% and is correlated with valuable hemodynamic burden due to cardiocirculatory changes which becomes a remarkable indirect cause of maternal mortality and poor fetal outcome. Ventricular septal defect (VSD) is one of the most common forms of heart disease among pregnant women, meanwhile the VSD-specific pregnancy data are insufficient. This case report addresses the anesthetics management for patient with uncorrected ventricular septal defect and pulmonary hypertension. Case: A 30-year-old multigravida with 37 weeks of gestation weighing 52 kg referred elective cesarean section and tubal ligation. She was compos mentis with arterial oxygen saturation was 87-88% room air. A grade IV/VI systolic murmur was heard at the second intercostal space of the left midclavicular line and the punctum maximum at the fourth intercostal spaces of the left sternal border. She had cyanotic in all of her extremities and clubbing fingers. Other examination is within normal limit. Titrated epidural was given at L1-2 level with parenteral levobupivacaine and fentanyl used as an adjuvant. The patient was stable during the surgery. Both maternal and fetal had a good outcome. The patient was discharged at the 7th day after surgery. Conclusion: To achieve a good outcome from management of the high-risk obstetric patients requires multidisciplinary approach involving anesthetist, obstetrician, and cardiologist in planning and managing the case.
Intravenous Immunoglobulin (IVIG) Therapy for COVID-19 Omicron (B.1.1.529) Variant with Acute Respiratory Distress Syndrome
Authors:   Anesthesiology and Intensive Therapy Specialist Program, Faculty of Medicine, Brawijaya University Indonesia, Sawitri Dewi Arum , Fatoni Arie Zainul ,   Department of Anesthesiology and Intensive Therapy, Faculty of Medicine, Brawijaya University Indonesia
Published: March 2023

Background: COVID-19 become the pandemic and infect more than million people. The World health organization and other clinical institutions have not yet established a definitive therapy to treat this disease due to a rapid virus mutation and anomaly. Case: A 78-year-old man who had previously confirmed COVID-19 was referred to the COVID-19 intensive care unit (ICU), the patient had geriatrics comorbid, cerebrovascular accident (CVA) infarction, and hypertension. The patient came with unresponsive awareness, and complaints of right hemiparesis and dysarthria. Other symptoms included cough, shortness of breath, and fever. Shortness of breath aggravates, blood pressure increases, and SpO2 was 86%. We decide intubated the patient because have a sign of respiratory distress. Patients receive standard therapy for COVID-19. On the second day, patient receive intravenous immunoglobulin (IVIG) gamaras 20 g. IVIG therapy perform for five days. On the fifth day of treatment in the ICU, the patient’s complaints had decreased and the patient breathed spontaneously with high flow nasal cannula (HFNC). Conclusion: Intravenous immunoglobulin (IVIG) therapy on the COVID-19 Omicron variant patient with ARDS produce a positive outcome. Patients treat with IVIG for 5 days show an improvement in breathing, laboratory result and chest x-ray.
Isolation and Characterization of α-Amylase Enzyme on Brown Planthopper (Nilaparvata lugens Stal) On Rice
Authors:   Universitas Jember, Syakuro Muhammad Yusuf Abdan , Haryadi Nanang , Muhlison Wildan , Sucipto Irwanto
Published: March 2023

Brown leafhopper (Nilaparvata lugens Stal) is an important pest in Indonesia that causes heavy losses. The rice was damaged by N. Lugens sucking plant liquid in the form of carbohydrates in the form of starch. Environmentally friendly control methods are needed to reduce the increasingly high use of inorganic pesticides. Control of N. lugens with biotechnology can be done by inhibiting the metabolic cycle in these insects. This method utilizes the proteins available in rice seeds to stop the performance of enzyme α-amylase in the digestive system of N. lugens. α-amylase is an enzyme that plays a role in the process of starch degradation so that it becomes a simpler form both in microorganisms. The characterization of α-amylase enzymes in insects is an important first step to the determination of appropriate protein inhibitors so that they can be used to produce pest-resistant Genetically Modified Organisms crops. The research was conducted in the Agrotechnology laboratory, University of Jember. The research began with isolation and purification of α enzymes from brown stems and then continued with testing of α-amylase activity. Test parameters include the effect of temperature, pH, and substrate concentration on the activity of the α-amylase enzyme. The results showed that supernatant extracted from brown planthoppers produces a clear zone in the agar medium, which means the activity of enzymes α-amylase in the hydrolysis of starch. The pH value of 6 provides the most optimum conditions for the activity of α enzymes. The α-amylase enzyme is able to work optimally in the temperature range of 30°C - 45°C, and experiences a decrease in activity when the temperature reaches 50°C. The α-amylase enzyme shows the ability to hydrolyze the amylase substrate to a concentration of 0.8 μg.μL-1.
Textile Industry Waste Pollution in the Konto River: A Comparison of Public Perceptions and Water Quality Data
Authors:   Universitas Brawijaya, Adjid Galang Ayuz Firstian Adjid , Kurniawan Andi , Nazriati Nazriati
Published: March 2023

Textile industry production activities in one of the Badas areas can have implications for the occurrence of dye liquid waste pollution in the Konto river flow. This implication leads to the public perception that there has been river pollution from textile dyeing liquid waste. In this case, public perceptions need to be analyzed as a form of river environmental monitoring activities. Therefore, public perceptions of pollution were compared with actual water quality data, especially related to dyes in river water, to link public perceptions with environmental resource management efforts. This study aims to analyze public perceptions of textile dye waste pollution and compare the analysis results with the river water quality analysis. Analysis of river water quality (dye content, BOD, COD) was conducted at five sampling points in Badas, Kuwik, Balungjeruk, and Wonorejo villages. Public perception was measured descriptively through interviews with respondents referring to the Slovin method. The analysis of public perceptions shows that the Public considers that there has been pollution of river water, mainly due to textile industry waste, along the Konto River. The results of the water quality analysis showed that dye concentrations were found at four sampling points except for Wonorejo Village. This result shows that the correlation between public perception and data on dye contamination only occurs in Badas, Kuwik, and Balungjeruk villages. In addition, the BOD/COD ratio indicates that pollution has occurred at all observation points in this study.
Exploring YidR Gene from Klebsiella pneumoniae To Design a Multi-epitope Vaccine Using Immunoinformatics Approach
Authors:   Universitas Brawijaya, Seputra Maulana Wildan , Susiati Hani ,   Saiful Anwar Hospital, Malang, Raras Tri Yudani Mardining ,   Universitas Brawijaya
Published: March 2023

Klebsiella pneumoniae is the main leading cause of hospital-acquired infection, leading to severe infections such as pneumonia and urinary tract infection. There is an urge to develop an efficient Klebsiella vaccine, and epitope-based vaccines may offer a practical choice. Therefore, this study aims to design an epitope-based vaccine construct. YidR gene is expressed in all strains of Klebsiella with 97.6% of sequence homology, which makes it a potential vaccine candidate. In silico approach was used to make a multi-epitope vaccine construct consisting of immunogenic epitopes against the YidR gene of Klebsiella. Acquired multi-epitopes vaccine was analyzed for antigenicity, allergenicity, toxicity, and various physicochemical parameters. Molecular docking simulation was performed using TLR2 and TLR4 to asses binding affinity with the designed vaccine construct. The results showed that the predicted multi-epitope-based vaccine candidate is non-allergen, non-toxic, and has an efficient binding affinity towards TLR2 and TLR4 that could effectively induce immune responses.
A comparative study on verbal affixes and auxiliary verbs as functional heads in Japanese and Korean
Authors: Aoyagi Hiroshi
Published: March 2023

It is true that languages differ, but they can only be different as the universal principles and parameters allow. Professor Hiroshi Aoyagi is interested in linguistic curiosities and the universality of language. He and his research team in Japan are investigating the possibility that
proto-Korean and proto-Japonic languages branched off from a common source thousands of years ago. Japanese and Korean have grammatical similarities but the typological relationship between the two is yet to be determined. Aoyagi is seeking to substantiate the hypothesis of a common origin
for the two languages and, in doing so, will contribute to the typology of the three major languages in the Far East: Japanese, Korean and Ryukyuan. In his 1999 book, Shiro Hattori stated that Korean may have a kinship relation with Japanese (next to Ryukyuan) and the two languages must have
split more than 4,000 years ago. Aoyagi believes that this conjecture, if tenable, accounts for the presence of double causatives, the absence of the benefactive auxiliary verbs and the absence of exclusive/adversity use of the passive morphemes in Korean and Ryukyuan. His studies involve
an explanation of the core morpho-syntactic characteristics of the Japanese and Korean languages. A similarity between Japanese and Korean is that they are both head-final agglutinative languages. Aoyagi will conduct a comparative study of how functional morphemes are combined in Japanese
and Korean. In his work, he is using the principles and parameters approach proposed by Noam Chomsky; namely Universal Grammar (UG).
Effects of Gum Arabic and its nanoparticles on hepato-renal toxicity induced by bromobenzene in male rats: Physiological, histological, and immunological studies
Authors:   Department of Biological Sciences, Faculty of Science, Northern Border University, Arar, Saudi Arabia, Al-Shaikh Turki M. ,   Department of Biology, College of Science and Arts at Khulis, University of Jeddah, Jeddah, Saudi Arabia
Published: March 2023

This experimental study investigates the possible protective effects of Gum Arabic (GA) and its nanoparticles in hepato- and reno-toxicity induced by bromobenzene (BB) in rats and possible mechanisms of action. Thirty-five adult male albino rats were sorted into the following: Group 1 (control), Group 2 (NPs), Group 3 (GA, received 2 ml/kg of 10%w/v aqueous suspension), Group 4 (Gum-NPs, received GA loaded NPs), Group 5 (BB), received 460 mg/kg, Group 6 (GA+BB) and Group 7 (GA-NPs+BB). Treatment was via oral gavage daily for 10 days. Liver and kidney functions were measured in sera and total antioxidant capacity (TAC) was measured in tissue homogenates, and renal and hepatic tissues expression of caspase-3 were immuno-histochemical assessed beside histological alteration using a light microscope. BB treatment produced impairment of liver and kidney functions and decreased TAC activities and increased caspase-3 expressions in the liver and kidney and altered liver and kidney structures. Co-administration of GA and GA loaded on NPs for 10 days alleviated damaged effects of BB, especially in GA-NPs groups in liver and kidney functions and structures, and decrease expression of caspase-3 in the tissues. In conclusion, GA and its NPs had protective actions versus BB-induced destruction of the kidney and liver due to its antioxidant, anti-inflammatory and anti-apoptosis actions.
SARS-CoV-2–Related Adaptation Mechanisms of Rehabilitation Clinics Affecting Patient-Centered Care: Qualitative Study of Online Patient Reports
Authors: Kühn Lukas , Lindert Lara , Kuper Paulina , Choi Kyung-Eun Anna
Published: March 2023

Background

The SARS-CoV-2 pandemic impacted access to inpatient rehabilitation services. At the current state of research, it is unclear to what extent the adaptation of rehabilitation services to infection-protective standards affected patient-centered care in Germany.

Objective

The aim of this study was to determine the most relevant aspects of patient-centered care for patients in inpatient rehabilitation clinics under early phase pandemic conditions.

Methods

A deductive-inductive framework analysis of online patient reports posted on a leading German hospital rating website, Klinikbewertungen (Clinic Reviews), was performed. This website is a third-party, patient-centered commercial platform that operates independently of governmental entities. Following a theoretical sampling approach, online reports of rehabilitation stays in two federal states of Germany (Brandenburg and Saarland) uploaded between March 2020 and September 2021 were included. Independent of medical specialty groups, all reports were included. Keywords addressing framework domains were analyzed descriptively.

Results

In total, 649 online reports reflecting inpatient rehabilitation services of 31 clinics (Brandenburg, n=23; Saarland, n=8) were analyzed. Keywords addressing the care environment were most frequently reported (59.9%), followed by staff prerequisites (33.0%), patient-centered processes (4.5%), and expected outcomes (2.6%). Qualitative in-depth analysis revealed SARS-CoV-2–related reports to be associated with domains of patient-centered processes and staff prerequisites. Discontinuous communication of infection protection standards was perceived to threaten patient autonomy. This was amplified by a tangible gratification crisis of medical staff. Established and emotional supportive relationships to clinicians and peer groups offered the potential to mitigate the adverse effects of infection protection standards.

Conclusions

Patients predominantly reported feedback associated with the care environment. SARS-CoV-2–related reports were strongly affected by increased staff workloads as well as patient-centered processes addressing discontinuous communication and organizationally demanding implementation of infection protection standards, which were perceived to threaten patient autonomy. Peer relationships formed during inpatient rehabilitation had the potential to mitigate these mechanisms.
Usability of a Community-Based Dementia Resource Website: Mixed Methods Study
Authors: Thomas Missy , Henderson Dean , Trudel Chantal , Thomas Neil
Published: March 2023

Background

Many individuals living with dementia want to live in their own homes for as long as possible. To do so, they frequently require assistance with activities of daily living, which is often provided by friends and relatives acting as informal care partners. In Canada, many informal care partners are currently overworked and overwhelmed. Although community-based dementia-inclusive resources are available to support them, care partners often struggle to find them. Dementia613.ca was created to make the process of finding community dementia-inclusive resources simpler and more straightforward by bringing them together in one eHealth website.

Objective

The objective of our study was to determine if dementia613.ca is meeting the goal of connecting care partners and persons living with dementia to dementia-inclusive resources in their community.

Methods

A review and assessment of the website was conducted using 3 evaluation methods: web analytics, questionnaires, and task analysis. Google Analytics was used to collect data related to website use over a 9-month period. Data on site content and user characteristics were collected. Furthermore, 2 web-based self-administered questionnaires were developed: one intended for care partners and persons living with dementia, and the other intended for businesses and organizations interested in serving persons living with dementia. Both gathered data on user characteristics and included standard questions used in website evaluations. Responses were collected over a 6-month period. Scenarios, tasks, and questions were developed for the moderated, remote, and task-analysis sessions. These tasks and questions determined how effectively persons living with dementia and their care partners can use dementia613.ca. Overall, 5 sessions were held with persons experiencing moderate cognitive decline and with care partners of persons living with dementia.

Results

This evaluation showed that the idea behind dementia613.ca is strong and appeals to persons living with dementia, their care partners, and the businesses and organizations serving this market. Participants indicated that it is a useful community resource that meets a previously unfulfilled need in the area, and highlighted the benefits of bringing community resources together on 1 website. In our questionnaire, >60% (19/29, 66%) of people living with dementia and their care partners and 70% (7/10) of businesses and organizations agreed that the website made it easier to find relevant dementia-inclusive resources. There is room for improvement; participants indicated that the navigation and search features could be further developed.

Conclusions

We believe that the dementia613.ca model could be used to inspire and guide the creation of dementia resource websites in other regions in Ontario and beyond. The framework behind it is generalizable and could be replicated to help care partners and persons living with dementia find local resources more easily.