bluuebunny/crossref_metadata_2025 huggingface dataset:
Setembro amarelo: a experiência de estudantes de enfermagem sob a lente da saúde mental
Authors: Costa Lucas Manoel Oliveira , Viana Izabel Luiza Rodrigues de Sousa , Silva Ruth Loureiro , Sousa Jéssica Lima , Silva Francisca da Costa Cunha da , Ponte Francisca Paula Lima , Monção Diully Horanna dos Santos de , Silva Lydyanne Fernandes dos Santos , Andrade Izane Luísa Xavier Carvalho , Gomes Maxwell Lopes
Published: July 2022

Objetivo: relatar a experiência de discentes de enfermagem na realização de uma ação social voltada à saúde mental de adolescentes. Método: trata-se de uma pesquisa do tipo descritiva, qualitativa, elaborado a partir da vivência de acadêmicos de enfermagem em uma ação de saúde desenvolvida com 60 adolescentes de uma escola pública de referência no município de Timon, Maranhão. Resultados e discussões: tornou-se evidente que a saúde mental é, o alicerce que fundamenta todo o processo evolutivo humano. Nesse sentido, durante a ação, percebeu-se a existência de um cenário urdido de adolescentes aflitos acerca desta fase de transição de ensino médio para possivelmente ensino superior, associada à pressão social por uma aprovação, bem como a persistente dúvida de escolha profissional. Ademais, tais anseios, são capazes de perpassarem o âmbito escolar, atingindo seus relacionamentos interpessoais, sendo notáveis catalizadores para a crescente incidência de transtornos psicológicos. Conclusão: diante deste contexto, compreendeu-se que a família e a escola, enquanto instituições sociais, se configuram, indubitavelmente, como meios para identificar, ensinar e discutir sobre esta temática, bem como proporcionar amparo para este público, uma vez que, a nível epidemiológico, se caracterizam como as principais vítimas de transtornos ansiosos e depressivos. Nesta lente, destaca-se o notável papel das terapias alternativas e complementares no processo de autocuidado e autoconhecimento por parte dos adolescentes, sendo uma medida suplementar neste cenário de indiscutível preocupação.
Formação continuada de professores em ensino de química à luz da abordagem CTSA: uma análise bibliográfica
Authors: Araújo Fabiana Moura de , Sampaio Caroline de Goes
Published: July 2022

O ensino da química preside grande relevância na formação do ensino básico dos alunos, principalmente quando as abordagens do CTSA são inseridas de forma paradigmáticas na vivência escolar e social dos discentes. Nesse condão, o tema abordou como objetivo geral a realização de uma análise de periódicos da plataforma google acadêmico, produzidos no período de 2018 a 2020, com enfoque na formação continuada no ensino de química com a abordagem Ciência, Tecnologia, Sociedade e Ambiente (CTSA), na perspectiva de contribuir para a melhoria do processo ensino-aprendizagem na disciplina de química. Contextualizando as especificações de metodologia, foram encontrados 758 artigos com o tema relacionado. Para esse estudo foi realizado a divisão dos artigos em três categorias: materiais instrucionais, práticas metodológicas, formação continuada. As contribuições da abordagem temática, podem ser visualizadas ante a exposição da base literária e a compatibilidade dos estudos e publicações científicas, coma formação continuada dos professores de química. Os resultados demonstram que as publicações atendem a realidade dos cursos de formação continuada, vez que os temas destacam as principais dificuldades dos professores, como a necessidade de integrar o ensino científico com a formação cidadã dos alunos, desengessando o ensino da química por meio das condutas metodológicas tradicionalistas, nas quais acreditavam que a melhor via de ensino, era definida pela memorização e repetitividade de práticas.
As ações e cuidados da assistência de enfermagem no Centro de Atendimento Psicossocial Álcool e outras Drogas (CAPS ad): uma revisão integrativa
Authors: Morais Izabela Maria de Oliveira , Silva Robson Mariano Oliveira , Costa Naazzon Januario , Nascimento Nara Geovane da Costa , Januario Palloma Oliveira da Silva , Silva Thaís Rodrigues de Sousa , Leite Cristina Limeira
Published: July 2022

A Reforma Psiquiátrica no Brasil ocorre através de movimentos sociais, pelos direitos dos pacientes psiquiátricos com superação dos atos de violência asilar e criação da rede de saúde mental com serviços em Centros de Atendimento Psicossociais (CAPS). Objetivou-se em compreender sobre as ações e cuidados da assistência de enfermagem no CAPS ad. Realizada revisão integrativa da literatura por meio de busca em periódicos indexados nas bases de dados LILACS, SciELO através da BVS do período de 2011 a 2022 para constatar a evolução da temática na última década. O levantamento dos estudos foi realizado entre janeiro e março de 2022 utilizando os Descritores em Ciência da Saúde (DeCS): cuidados de Enfermagem, saúde mental, serviços de saúde mental. Foram usados 7 artigos publicados em português. A técnica de análise de conteúdo utilizada para categorização: Categoria temática 1: As ações da enfermagem na assistência no contexto da saúde mental e Categoria temática 2: O papel do enfermeiro no CAPS ad. Evidenciaram-se mudanças no reconhecimento das ações do enfermeiro publicações anteriores mencionam sobre profissional não ter papel definido no cenário da atenção em reabilitação psicossocial além de possui pouco preparo específico. Contudo publicações recentes reconhecem o papel do enfermeiro na assistência dos pacientes dependentes químicos como fundamental no tratamento e recuperação. Espera-se que à medida que houver mais discussões sobre a temática seja compreendida de forma mais ampliada sobre o papel do enfermeiro no CAPS ad.
Efeitos deletérios do uso crônico de álcool sobre a função orgânica humana: uma revisão integrativa de literatura
Authors: Oliveira Amarildo Borges da Silva , Pereira Ana Caroline Prado , Figueiredo Bárbara Queiroz de , Ferreira Clarissa de Castro
Published: July 2022

Introdução: a ingestão em excesso de bebidas alcoólicas é considerada o quinto fator de risco mais importante para a ocorrência de mortes prematuras e incapacidades no mundo, dentre elas as hepáticas, nutricionais e certos tipos de cânceres, além de causar dependência química e facilitar a ocorrência de violências e acidentes. Objetivo: elucidar os efeitos deletérios do álcool sobre a função orgânica humana. Metodologia: trata-se de uma pesquisa descritiva do tipo revisão integrativa da literatura.A pesquisa foi realizada através do acesso online nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Electronic Library Online (Scielo), Cochrane Database of Systematic Reviews (CDSR), Google Scholar, Biblioteca Virtual em Saúde (BVS) e EBSCO Information Services. Resultados e discussão: o uso nocivo do álcool pode afetar várias partes do corpo, provocando doenças como câncer, pancreatite, doenças hepáticas, problemas gastrintestinais, neuropatia periférica, problemas cardíacos e vasculares, prejuízos cerebrais e disfunções imunológicas. consumo excessivo e continuado de álcool aumenta o risco para complicações de saúde. Considerações finais: os efeitos do álcool sobre cada indivíduo são diferentes e dependem de uma série de fatores, mesmo quando consumido em quantidades iguais.
Experimental and numerical investigations of mixed
convection in turbine cavities for more flexible operations
Authors: Murat Oguzhan , Rosic Budimir , Tanimoto Koichi , Egami Ryo
Published: July 2022

Since the renewable sources, which have gained great attention due to the low-carbon policies, are inherently intermittent, the conventional power generation systems will be in use to meet the power demand. These systems, however, must be capable of operating along with renewables, which will lead to a need for more operational flexibility with frequent system ramps. Therefore, understanding and control of thermal stresses and clearances are essential for improving flexibility of conventional power plants. Computational fluid dynamics tools are of great importance in predicting the turbomachinery flows design since the direct measurements of detailed and spatial flow and temperature distribution are often not trivial in the real engines. During shut-down regimes of steam turbines, natural convection takes place along with relatively weak forced convection which is not strong enough to prevent a rising thermal plume leading to a non-uniform cooling in the turbine cavities. Although natural and forced convection have been studied separately in the literature, mixed type of flows in turbine cavities have not been investigated extensively.

This paper provides unique experimental data set for validation and development of the predictive tools, which is generated from the detailed flow field measurements in a test facility designed for mixed type of flows in the turbine casing cavities with engine representative conditions. Additionally, large eddy simulations have been performed and validated against the generated experimental data, to gain deeper insight into the flow field. Thus, this paper offers a great insight in these complex flow interactions and unique experimental data for enabling the flexible operations and the development of advanced turbulence modelling.
Upaya Pengembangan Potensi Desa Melalui Rancang Bangun Peraturan Desa Dudepo Kecamatan Patilanggio Kabupaten Pohuwato
Authors: Tijow Lusiana Margareth , Abdussamad Zamroni
Published: July 2022

Tujuan penulisan artikel ini sebagai luaran laporan Program Pengabdian KKN sebagai bentuk upaya untuk meningkatkan dan mengembangkan potensi desa yang ada, sehingga dapat mewujudkan pembangunan desa. Selain itu sosialisasi dan penyuluhan terkait dengan rancang bangun peraturan desa tentang pengembangan potensi Desa Dudepo di Kabupaten Pohuwato tersebut kepada aparat dan masyarakat desa dimaksudkan untuk memberikan pengetahuan sekaligus keselarasan persepsi dalam melakukan ikhtiar kolektif pembangunan desa melalui pengembangan potensi desa di Kabupaten Pohuwato, serta Pembentukan SATGAS P2D (Satuan Tugas Pengembangan Potensi Desa) yang dimaksudkan untuk mengidentifikasi dan melakukan pendampingan mulai dari tahapan identifikasi potensi desa, perencanaan, pengelolaan dan pengembangan potensi desa sebagai bentuk perwujudan desa tangguh dan berkembang untuk mencerminkan pelaksanaan pembangunan di desa. Hasil dari kegiatan ini adalah pelaksanaan pendampingan pembentukan peraturan desa sesuai dengan potensi Desa Dudepo, data-data terkait potensi yang ada di Desa Dudepo, Pembentukan SATGAS P2D (Satuan Tugas Pengembangan Potensi Desa) yang melibatkan aparat desa dan masyarakat untuk memudahkan koordinasi, komunikasi program dan kegiatan pengembangan potensi desa di Desa Dudepo.Kata Kunci: Pengembangan; Rancang Peraturan Desa; Potensi Desa.
Model Pemberdayaan Kader Kesehatan Desa Dalam Upaya Menekan Kasus Stanting Di Desa Suka Makmur Kecamatan Patilanggio Kabupaten Pohuwato
Authors: Wantu Fence M , Hippy Januar
Published: July 2022

Abstrak Masalah anak pendek (stunting) adalah salah satu permasalahan gizi yang menjadi fokus Pemerintah Indonesia, Stunting adalah status gizi yang didasarkan pada indeks PB/U atau TB/U dimana dalam standar antropometri penilaian status gizi anak, hasil pengukuran tersebut berada pada ambang batas (Z-Score) -2 SD sampai dengan -3 SD (pendek) dan -3 SD (sangat pendek). Stunting merupakan permasalahan gizi kronis yang menjadi prioritas pembangunan nasional yang tercantum dalam RPJMN 2020-2024. Kabupaten Pohuwato Kecamatan Patilango desa Suka Makmur melakukan metode Akselerasi Pencegahan Stunting di Desa Suka Makmur sebagai panduan dana arah kebijakan bagi pemerintah desa dan masyarakat untuk pencegahan stunting di desa Suka Makmur. Selain itu sosialisasi dan penyuluhan terkait dengan rencana strategis akselerasi pencegahan stunting tersebut kepada kader kesehatan dan masyarakat desa dimaksudkan untuk memberikan pengetahuan sekaligus penyamaan persepsi dalam melakukan ikhtiar kolektif pencegahan stunting di Desa Suka Makmur Kecamatan Patilanggio Kabupaten Pohuwato, serta launching Kader Kesehatan Desa untuk pencegahan Stunting di Desa Suka Makmur Kecamatan Patilanggio Kabupaten Pohuwato dengan tujuan semakin memasifkan akselerasi pencegahan stunting di dusun-dusun hingga ketingkat keluarga.Kata Kunci : Kebijakan; Akselerasi; Pencegahan Stunting.
Empowerment of Tourism With Eco-Green Concept-Based Ecotourism in Botubarani Village
Authors: Podungge Abdul Wahab , Hunawa Robby , . Alisa , Sipahutar Christy Anastasya
Published: July 2022

ABSTRACThis research aims to provide knowledge and skills to the people of Botubarani Village with an approach to solve local problems with problem-solving techniques through design thinking. The output targets of this program include the opportunity for independent study program students certified as independent campuses to analyze problems that exist in the community related to ecotourism. The implementation method in this activity is Focus Group Discussion (FGD) between field supervisors and students with partner groups and the community. Conduct direct observations together with partners and document the potential that will be developed with the assisted communities in Botubarani Village. Designing program implementation scenarios, conducting training and mentoring for the utilization of waste.Ecotourism problems in the village of Botubarani were discussed by a team of writers using the Customer validation technique. The results of interviews with tourists and customers will then provide an overview of the solutions that must be carried out by our team later through product validation techniques. Products that have been validated will then be realized through a prototyping procedure which will later be distributed to residents in the form of training and also enrichment of concepts through open discussions. Because this project is based on human centricity, all solutions and problems are obtained through observation and user validation. With these procedures and techniques, we are expected to be able to provide the best solutions for validated problems to realize sustainable and sustainable ecotourism with an eco-green concept.
Peningkatan Kesehatan Masyarakat Desa Melalui Pembentukan Gugus Tugas Pencegahan Stunting dan Penyuluhan Hukum Kesehatan Lingkungan Di Desa Buntulia Tengah
Authors: Puluhulawa Mohamad Rusdiyanto , Achir Nuvazria
Published: July 2022

ABSTRAK Mewujudkan ketahanan masyarakat dan desa dibidang kesehatan, dilakukan dengan beberapa Program yaitu berupa Pembentukan Gugus Tugas dan Sosialisasi Pencegahan Stunting serta Penyuluhan Hukum Kesehatan Lingkungan. Hal ini berkaitan dengan pengembangan Desa Sehat, dimana pemerintah setempat perlu mengupayakan dan memaksimalkan usaha, khususnya yang berdampak pada kondisi kesehatan masyarakat dan lingkungan di era pandemik maupun new normal. Olehnya, pembentukan Gugus Tugas Pencegahan Stunting merupakan unit khusus yang keberadaanya di desa, berfungsi mencatat riwayat penyakit yang diderita masyarakat terutama bagi kaum perempuan dan anak, agar memudahkan untuk melakukan pengobatan dan tindakan lanjut medis, serta meningkatkan peran warga dalam menolong dirinya khususnya pada era pandemi maupun non pandemi. Selain itu, gugus tugas ini paling tidak bisa membantu mengurangi masalah prosedur pelayanan kesehatan, memudahkan koordinasi dengan pemerintah desa dan daerah dalam upaya meningkatkan penanggulangannya. Unit ini juga dapat mengontrol masyarakat secara rutin khususnya bagi para ibu hamil dan persiapan kelahiran bayi, serta pengawasan terhadap gizi dengan bekerjasama Pusat Kesehatan Masyarakat (Puskemas) setempat. Sebagai tugas utama dari Gugus ini ialah melaksanakan sosialisasi dan kampanye mengenai pencegahan stunting agar warga desa terhindar dari penyakit tersebut.            Berkenaan dengan kondisi pandemi covid 19 yang melanda negara sampai ke pelosok daerah, maka perlu pemahaman nilai-nilai hukum baik lingkungan maupun hukum kesehatan. Oleh karena itu, peningkatan kesadaran masyarakat dalam menjaga masyarakat desa agar senantiasa sehat, maka penyuluhan hukum tentang kesehatan dan lingkungan menjadi sangat diperlukan untuk menjaga aktivitas yang dilakukan demi menjaga kelestarian dan sebagai pengembangan desa sehat di Buntulia Tengah. Kegiatan lainnya juga adalah mengaplikasikan program Desa Sehat dengan melaksanakan kegiatan olahraga dan bersih lingkungan bersama masyarakat, untuk mewujudkan ketahanan desa. Kata Kunci : Desa, Kesehatan Masyarakat, Gugus Tugas, Stunting
Methodological and organizational approaches to ensure the efficiency of management and use of budget expenditures
Authors:   Accounting Chamber of Ukraine, RADIONOV Yurii
Published: July 2022

Introduction. The low pace of socio-economic development of the country indicates signi?cant problems in ensuring the e?cient use of ?nancial resources of the state. This issue is relevant in a state of martial law, ever-increasing social needs, limited ?nancial resources. Problem Statement. Determination of the economic essence of the e?ective use of budget expenditures and the development of an e?ective methodological and organizational approach. Purpose. To generalize the available tools, theoretical knowledge, practical experience to develop certain methodological and organizational approaches to ensure the e?ectiveness of management and use of budget expenditures in modern conditions of socio-economic development of the country. Methods. General scienti?c and special methods are used: analysis, synthesis, grouping, description, modeling, comparison, theoretical generalization and abstract-logical. Results. Attention is focused on the fact that “e?ciency” as an economic category is a complex issue. Scienti?c approaches to the toolkit of criteria application and performance evaluation developed by Ukrainian and foreign scientists have been systematized. The economic essence of the e?ective use of budget expenditures and the methodological and organizational approach proposed by the author is revealed. Along with the program- target method of budgeting, it is an additional tool that will improve the mechanism of management and use of budget expenditures, will enable managers of budget funds to always achieve the goal of budget programs, investment projects, the best indicators of the country’s socio-economic development, and increase the e?ectiveness of budget policy. Conclusions. The ?nal decision on the issues of expanding knowledge about the economic essence of the e?ective use of budget expenditures, introducing the tools of the methodological-organizational approach, along with the program-target method of budgeting, depends on the state authorities. It is advisable to follow the practice of EU member states in order to ensure the transparency of the budget system, improve the budget process, increase the level of citizens’ incomes, social standards, the e?ectiveness of budget policy, and the dynamics of the country’s socio-economic development.
Towards greater health security, one choice at a time
Authors: Brindley Heather
Published: July 2022

These slides accompany the 200-word abstract in the article "Outbound Insights", which was accepted for presentation at the 2022 Global Health Security Conference. The slides summarise the 2019 and 2022 status of global health security, and profile the situation in terms of the information challenges faced by real-time decision-makers. The proposed solution is the implementation blueprint of the Open Knowledge Reference Model (OKRM). The blueprint storyboard describes a Worldwide Mosaic Web of Informed and Communicating People. Solution components include the PatternBank, Knowledge-as-a-Service, and global peer-to-peer review and audit of the OKRM assets. The presentation concludes with a named call to action to save a planet in danger of Ecosystem Arrest: Code Midnight Blue.
Антипольська діяльність чорносотенців на Волині на початку ХХ ст.
Authors: Melnichuk Oleg , Tsetsyk Yaroslav , Kizlova Antonina
Published: July 2022

Метою статті є визначення особливостей антипольського вектору діяльності Почаївського відділу Союзу російського народу і православного духовенства Волині на початку ХХ ст. Проаналізовано ключові фактори, які вплинули на ускладнення міжнаціональних взаємовідносин у регіоні. Встановлено, що в результаті активної та цілеспрямованої діяльності чорносотенців на Волині спостерігалося загострення не лише міжнаціональних, а й міжконфесійних взаємовідносин. Методологія дослідження ґрунтується на використанні як загальнонаукових методів дослідження (узагальнення, аналізу й синтезу), так і спеціальних історичних (порівняльно-історичного та хронологічного), що у поєднанні з принципами історизму, поліфакторності та об’єктивності сприяли неупередженому висвітленню поставлених завдань.

Наукова новизна роботи полягає у тому, що автори, на основі матеріалів періодичної преси досліджуваного періоду й архівних документів, з’ясували особливості антипольської діяльності чорносотенців і православного духовенства на Волині на початку ХХ ст., проаналізували результати досліджуваного напряму діяльності Союзу російського народу.

Висновки. Доведено, що спільно з кліром Російської православної церкви, провідні діячі якої були ідеологами чорносотенного руху на Волині, «союзники» також активно протидіяли зростанню впливів Римо-католицької церкви у регіоні. Окрему увагу приділено участі у виборах до Державної думи та протистоянню чорносотенців і польських поміщиків, залученню до цього протистояння представників органів влади, які їх підтримували і намагалися послабити впливи польської аристократії, що, зрештою, визначалося внутрішньою політикою імперії. На основі неупередженого аналізу документів з’ясовано, що «союзники» у протидії зростанню впливів римо-католиків у досліджуваний період на сторінках своїх пресових видань часто друкували сфабриковані звинувачення проти опонентів. У цьому напрямі чорносотенці діяли в контексті внутрішньої політики імперії. Завдяки підтримці органів влади, вони мали змогу проводити активну та войовничу антипольську кампанію. Це робилося з чітко визначеною метою: послабити у регіоні позиції та впливи польської аристократії, котра, незважаючи на довготривале перебування регіону в складі імперії, зберігала свою національну ідентичність і конфесійну належність, а це суперечило імперським планам з русифікації регіону.
Detail Investigation of Frequent Nocturia and its Improvement by the Administration of Diuretic
Authors: Tadao Shimamura , Hiroshi Bando , Masahiko Takemura , Jouji Shunto , Hiroko Ogawa , Miwako Nakanishi , Osami Watanabe , Shinji Nagahiro
Published: July 2022

Background: For elderly people, nocturia has been often found associated with other diseases. Case presentation: The case is 88-year-old male with hypertension, Cardiovascular Disease (CVD), Diabetes, Chronic Kidney Disease (CKD). He developed nocturia and insomnia, and then checked daily water balance by himself. Results: Basic situation showed water intake/urine volume were 750mL/1030mL/day, in which urine ratio of day/night was 27%/73% with waking up twice during night. He was given furosemide 20mg, per os at 1500h. Same study showed 960mL/1090 mL, and urine ratio as 77%/23% with no waking up. Discussion and Conclusion: From some reports, Odds Ratio (OR) for combination of nocturia shows 1.25 for hypertension, 1.23/1.74 for CVD (mild/severe). Consequently, current treatment would contribute adequate managements for nocturia problem.
Family Planning Counseling and Safari (IUD and Implant)
Authors: Rosiyana Ni Made , Enggar Enggar , Tumani Yuni Kristiani , Margareta Paula Klara
Published: July 2022

Introduction: A well-implemented family planning program can prevent maternal death through the use of contraception. The use of long-term contraceptives such as IUDs and implants is considered much more effective in reducing birth rates, but their use is still very low. The purpose of this community service is expected to be able to open insight and foster interest in fertile age couples (PUS) in making decisions to join in the use of long-term contraceptives, especially IUDs and implants. The method used is counseling to WUS and PUS who are domiciled in Loru Village, Sigi Biromaru District about IUDs and implants. The number of EFA targets in counseling was 28 people, which was then carried out on a family planning safari for counseling participants who decided to use an IUD or implant contraceptive device. The result of this community service activity is a change in attitude in choosing contraceptives after counseling, marked by 6 people deciding to use long-term IUD contraception and 9 other people deciding to use implant contraceptives. The need for contraceptive counseling that involves husbands and families, so that there are no obstacles in decision making by mothers.
Cytogenetics: a reliable tool for the diagnosis and prognosis of hematological malignancies
Authors: Malla Tahir Mohiuddin , Najar Ashaq Hussain , Masoodi Shariq R , Shah Zaffar Amin
Published: July 2022

Aim: The current review aims to provide a holistic overview of the cytogenetic techniques used to diagnose and diagnose haematological malignancies.

Background: Since the discovery of the Philadelphia chromosome as a sole abnormality for diagnosing chronic myeloid leukaemia, cytogenetics has been widely used to diagnose malignancies in blood. With the introduction of advanced cytogenetic techniques like Fluorescent In-Situ Hybridization, Spectral Karyotyping and Comparative Genomic Hybridization, identification of clones and monitoring the response to drug therapy has now become easy as these have overcome the challenges of conventional cytogenetics like culture failures, poor morphology of chromosomes and low mitotic index.

Review results: Ample evidence suggests that chromosomal aberrations are critical early indicators of progressing to a hematopoietic disorder. Conventional cytogenetics augmented with molecular cytogenetic techniques, immunophenotyping and real-time PCR not only aids in identifying specific clones but also characterizes haematological malignancies, predicting and assessing the minimal residual disease status during their management.

Conclusion: We conclude that in this era of array diagnostics, cytogenetic techniques are still reliable for accurate diagnoses, characterization and prognosis of haematological malignancies.

Clinical Significance: The present review discusses the role of cytogenetic tools in the diagnoses and prognosis of various haematological malignancies. It also provides an insight into the technical challenges encountered while performing these studies and the considerations to overcome them.
AP3S1 is a Novel Prognostic Biomarker and Correlated With an Immunosuppressive Tumor Microenvironment in Pan-Cancer
Authors: Wu Gujie , Chen Mianxiong , Ren Hefei , Sha Xinyu , He Min , Ren Kuan , Qi Juntao , Lin Feng
Published: July 2022

Background: Adaptor-related protein complex 3, sigma one subunit (AP3S1) is one of the encoding subunits of the adaptor complex AP-3. However, its role in various tumor types and relationship with the tumor immune microenvironment (TIME) remains unclear.

Methods: AP3S1 expression was analyzed using datasets from The Cancer Genome Atlas, Genotype-Tissue Expression, UALCAN, and HPA databases. Then, we performed a systematic analysis of the genetic alterations, clinical features, and prognostic value of AP3S1 in pan-cancer. Gene set enrichment analysis (GSEA) and gene set variation analysis (GSVA) were used to identify the signaling pathways associated with AP3S1. The correlation between immune cell infiltration and AP3S1 expression was analyzed using immune cell infiltration data from the ImmuCellAI, TIMER2, and a previous study. Finally, we analyzed the association of AP3S1 with tumor mutational burden (TMB), microsatellite instability (MSI), and immune-related genes.

Results: We found AP3S1 overexpression in most tumors and a significant association with low survival rates. GSEA and GSVA results show that AP3S1 is involved in tumor progression and associated with immune pathways in different tumor types. We also found that AP3S1 expression was positively correlated with the level of infiltration of immunosuppressive cells (tumor-associated macrophages, cancer-associated fibroblasts, Tregs) and negatively correlated with immune killer cells, including NK cells and CD8+ T cells, in pan-cancer. The expression of AP3S1 could affect TMB and MSI in various cancers. In addition, AP3S1 was positively correlated with most immunosuppressive genes, including PD-1, PD-L1, CTLA4, LAG3 and TIGIT in most cancer types.

Conclusion: Our study reveals that AP3S1 is a potential pan-cancer oncogene and plays an essential role in tumorigenesis and cancer immunity. Elevated expression of AP3S1 indicates an immunosuppressive microenvironment and can be used as a potential prognostic biomarker and a target for immunotherapy.
Periodic Motion in the Chaotic Phase of an Unstirred Ferroin-Catalyzed Belousov Zhabotinsky Reaction
Authors: Wodlei Florian , Hristea Mihnea R. , Alberti Giuseppe
Published: July 2022

The Belousov Zhabotinsky reaction, a self-organized oscillatory color-changing reaction, can show complex behavior when left unstirred in a cuvette environment. The most intriguing behavior is the transition from periodicity to chaos and back to periodicity as the system evolves in time. It was shown that this happens thanks due to the decoupling of reaction, diffusion and convection. We have recently discovered that, as the so-called chaotic transient takes place, periodic bulk motions in form of convective cells are created in the reaction solution. In this work we investigated this phenomenon experimentally by changing cuvette size and reaction volume, in order to allow different types of convection patterns to appear. So far, we have observed single and double convection cells in the system. There are indications that the convection patterns are connected to the duration of the chaotic phase. A simplified mathematical model confirms the form and dynamics of the observed convection cells and explains the connection between chemical chaos and hydrodynamical order.
Gold Nanocluster-Encapsulated Hyperbranched Polyethyleneimine for Selective and Ratiometric Dopamine Analyses by Enhanced Self-Polymerization
Authors: Zhang Jing , Liu Ying , Liu Yang , Liu Wencai , Lu Fengniu , Yuan Zhiqin , Lu Chao
Published: July 2022

The exploitation of selective and sensitive dopamine (DA) sensors is essential to more deeply understand its biological function and diagnosis of related diseases. In this study, gold nanocluster-encapsulated hyperbranched polyethyleneimine (hPEI-Au NCs) has been explored as the specific and ratiometric DA nanoprobe through hPEI-assisted DA self-polymerization reactions. The Au NCs encapsulation not only provides a fluorescent internal reference but also enhances the DA self-polymerization by weakening the proton sponge effect of the hPEI layer. Rapid and sensitive DA detection is realized through the proposed hPEI-Au NC nanoprobe with a limit of detection of 10 nM. The favorable selectivity over other possible interferents including amino acids, sugars, and salts is due to the specific self-polymerization reaction. The DA analysis in urine samples with small relative standard deviations has been accomplished with an hPEI-Au NC nanoprobe.
Advancement in the Development of Therapeutics Against Zika Virus Infection
Authors: Li Kangchen , Ji Qianting , Jiang Shibo , Zhang Naru
Published: July 2022

Zika virus (ZIKV), a re-emerging arbovirus, causes teratogenic effects on the fetus and normal nerve functions, resulting in harmful autoimmune responses, which call for the development of therapeutics against ZIKV infection. In this review, we introduce the pathogenesis of ZIKV infection and summarize the advancement in the development of therapeutics against ZIKV infection. It provides guidance for the development of effective therapeutics against ZIKV infection.
Comparing Individuals With PPA to Individuals With AD: Cognitive and Linguistic Profiles
Authors: Karpathiou Nomiki , Kambanaros Maria
Published: July 2022

Primary Progressive Aphasia (PPA) is a degenerative condition characterized by the progressive loss of language function. In PPA, aphasia is the most prominent deficit at onset. On the other hand, memory deficits are the hallmark of Alzheimer's disease (AD). The first aim of the study was to establish differences on neuropsychological testing and connected speech production between Greek-speaking individuals with AD and PPA. The second aim was to investigate the executive deficit involvement in the two conditions. Ten individuals with PPA and 9 individuals with AD took part in a comprehensive cognitive-linguistic evaluation. Fifteen demographically matched neurologically healthy adults served as controls. Participants were evaluated using a battery of neuropsychological measures. Quantitative production analysis and acoustic analysis were performed to calculate narrative and temporal measures of the participants' speech. Participants with PPA differed significantly from participants with AD on linguistic measures. They performed worse on the long frequent sentences' subtest of the Sentence Repetition Test and they produced fewer narrative and unique words in picture description. They also produced shorter, less elaborated sentences, and made more phonological errors. The two groups did not differ significantly on memory, executive, visuospatial and semantic composite measures. Compared to neurotypical adults, participants with AD were impaired in memory, and executive function. They also exhibited lexical retrieval difficulties, as well as difficulties in linguistic tasks with an increased processing load. Participants with PPA performed within normal limits on the delay conditions of episodic memory measures. However, they too were impaired in executive tasks, especially for short-term memory and verbal fluency. The production of phonological errors, difficulty in repeating long frequent sentences, and the production of simple and short sentences has differentiated participants PPA not only from neurotypical controls but also from participants with AD. No single measure could differentiate the AD group from the other two groups. These findings should be interpreted with caution considering the small sample size.
The Prospects of Monte Carlo Antibody Loop Modelling on a Fault-Tolerant Quantum Computer
Authors: Allcock Jonathan , Vangone Anna , Meyder Agnes , Adaszewski Stanislaw , Strahm Martin , Hsieh Chang-Yu , Zhang Shengyu
Published: July 2022

Quantum computing for the biological sciences is an area of rapidly growing interest, but specific industrial applications remain elusive. Quantum Markov chain Monte Carlo has been proposed as a method for accelerating a broad class of computational problems, including problems of pharmaceutical interest. Here we investigate the prospects of quantum advantage via this approach, by applying it to the problem of modelling antibody structure, a crucial task in drug development. To minimize the resources required while maintaining pharmaceutical-level accuracy, we propose a specific encoding of molecular dihedral angles into registers of qubits and a method for implementing, in quantum superposition, a Markov chain Monte Carlo update step based on a classical all-atom force field. We give the first detailed analysis of the resources required to solve a problem of industrial size and relevance and find that, though the time and space requirements of using a quantum computer in this way are considerable, continued technological improvements could bring the required resources within reach in the future.
Early Cretaceous Volcanic Edifice Activity in the Sulu Orogenic Belt: Evidences From Volcanic-Sedimentary Rhythm Characteristics in Lingshan Island, Eastern Shandong Province, China
Authors: Liu Ruiyang , Zhou Yaoqi , Dong Shihui , Zhou Tengfei , Mu Hongyu , Bai Bingyang , Li Sunyi , Chen Tongtong , Zhang Zhenkai
Published: July 2022

A rhyolitic tuff-mudstone interbedded rock outcrop with a good rhythm is found in the Yangjiaodong area of Lingshan Island, eastern Shandong Province. The volcanic eruption dynamics process was investigated by using the rhythm of volcanic accumulation method. Combined with the geologic setting of the study area, the parameter deposition rate is 6.5 m/Ma, and the mudstone compaction factor is 0.3 because the study area is the Ri-Qing-Wei Basin, which is the volcanic back-arc basin with insufficient source supply. Based on this, the time span of the analyzed sample was calculated to be 2.24 Ma, which represents the duration of this eruption event. We used software called Acycle to finish this research. The result shows cyclicity of 2.296, 5.78, 8.475, and 15.625 kyr and the scales of 2.17, 2.94, 3.12, and 18.87 m repeatability. Considering that magma eruption is affected by changing melt conditions, the crystallinity, water content, temperature, and pressure are comprehensively considered “activation conditions” to predict the dynamic process within the near-surface magma chamber, which is characterized using a pulsed volcanic eruption model.
The Thyroid Condition and Residual Clinical Signs in 31 Existing Endemic Neurological Cretins After 42 Years of Iodine Supplementation in China
Authors: Li Jianshuang , He Yanhong , Ren Bingxuan , Zhang Zhaojun , Meng Fangang , Zhang Xiaoye , Zhou Zheng , Li Baoxiang , Li Fan , Liu Lixiang , Shen Hongmei
Published: July 2022

Backgroud

Endemic cretinism is the most severe manifestation among the iodine deficiency-related disorders. The clinical status of the cretins may be modified subsequently by the duration and severity of the disease. We aimed to reassess the clinical status and thyroid function of 31 surviving “neurological cretins” after 42 years of iodine supplementation in a historically severely iodine deficiency area of China.

Methods

It was a cross-sectional study in design and we investigated all 31 surviving neurological cretins and 85 controls. A detailed neurological examination was conducted on each patients. All the participants were given a questionnaire and underwent B-mode ultrasonography of the thyroid. The serum levels of thyroid hormones, thyroid antibodies, serum iodine concentration (SIC) and urine iodine concentration (UIC) were measured.

Results

The neurological cretins had shorter stature than that of the control. Neurological damage is still present in patients with cretinism. The prevalence of subclinical hypothyroidism and thyroid nodule in the cretins was significantly higher (χ2 =4.766, P=0.029 and χ2 =17.077, P<0.0001, respectively) compared with the control. After adjusting for confounding factors, endemic neurocretinism was found to be an independent risk factor for subclinical hypothyroidism (OR=4.412; 95% CI: 1.358–14.334; P=0.014) and thyroid nodule (OR=6.433; 95% CI: 2.323–17.816; P<0.0001).

Conclusions

Iodine supplementation after birth does not reverse the neurological damage that results from maternal/foetal hypothyroidism in utero and is subsequently manifested as neurological cretinism. There is a cross-sectional association between endemic neurocretinism and subclinical hypothyroidism and thyroid nodule.
A Meandering-Capturing Wake Model Coupled to Rotor-Based Flow-Sensing for Operational Wind Farm Flow Prediction
Authors: Lejeune Maxime , Moens Maud , Chatelain Philippe
Published: July 2022

The development of new wake models is currently one of the key approaches envisioned to further improve the levelized cost of energy of wind power. While the wind energy literature abounds with operational wake models capable of predicting in fast-time the behavior of a wind turbine wake based on the measurements available (e.g., SCADA), only few account for dynamic wake effects. The present work capitalizes on the success gathered by the Dynamic Wake Meandering formulation and introduces a new operational dynamic wake modeling framework aimed at capturing the wake dynamic signature at a low computational cost while relying only on information gathered at the wind turbine location. In order to do so, the framework brings together flow sensing and Lagrangian flow modeling into a unified framework. The features of the inflow are first inferred from the turbine loads and operating settings: a Kalman filter coupled to a Blade Element Momentum theory solver is used to determine the rotor-normal flow velocity while a Multi-Layer Perceptron trained on high-fidelity numerical data estimates of the transverse wind velocity component. The information recovered is in turn fed to a Lagrangian flow model as a source condition and is propagated in a physics-informed fashion across the domain. The ensuing framework is presented and then deployed within a numerical wind farm where its performances are assessed. The computational affordability of the proposed model is first confirmed: 7 × 10−4 wall-clock seconds per simulation second are required to simulate a small 12 turbines wind farm. Large Eddy Simulations of wind farm using advanced actuator disks are then used as a baseline and a strong focus is laid on the study of the wake meandering features. Comparison against the Large Eddy Simulation baseline reveals that the proposed model achieves good estimates of the flow state in both low and high Turbulence Intensity configurations. The model distinctly provides additional insight into the wake physics when compared to the traditional steady state approach: the wake recovery is consistently accounted for and the wake meandering signature is captured as far as 12D downstream with a correlation score ranging from 0.50 to 0.85.
Analysis of Regional Carbon Emission Decoupling Coupling in China Based on ArcGIS Analysis-Empirical Evidence From Urban-Rural Integration in Fujian Province
Authors: Xie Renshan , Yu Dongye , Zhang Xingyuan , Yang Ze , Yang Jianzhou , Ye Jie
Published: July 2022

China’s ambitious measures for developing a low-carbon economy led to the “double carbon” target initiation. Under this national goal, reaching peak carbon emissions by 2030 is desired. This should not come at the cost of economic growth; which means carbon emissions can be reduced while economic growth can be achieved simultaneously. To realise this strategic reform, the first pilot ecological civilisation zone in Fujian Province of China was initiated; its outcome is set to be the responsible case for such initiations aiming at increased low-carbon economy development. Therefore, it is essential to investigate the relationship between carbon emissions and economic growth based on the evidence. Hence, we applied a model that combines the Tapio and Coupled coordination. Combining the Tapio and the coupled coordination models allows us to analyse carbon emissions and economic growth in Fujian Province over 20 years, i.e., 2001–2020. First, we divided the urban-rural integration process into four stages following China’s Five-Year Plan (FYP): T1 (2001–2005), T2 (2006–2010), T3 (2011–2015), and T4 (2016–2020). Second, ArcGIS mapping was used to represent the spatial evolution pattern of low-carbon economic development in Fujian Province. We observed that the low-carbon economy in Fujian Province had reached a point where the economic growth rate has already exceeded its carbon emission growth rate and is currently in a weak decoupling state. In addition, there observed a bifurcation pattern between carbon emissions and economic growth, especially in the coastal cities that are out of balance, whereas the inland cities are being coordinated. Overall, it is observed that the concept of ecological civilisation is crucial for China to achieve the “double carbon goal,” and it is high time to create accelerating measures that guide the integration of urban and rural areas in the future with appropriate infrastructure.
Performance Enhancement of an Economically Operated DC Microgrid With a Neural Network–Based Tri-Port Converter for Rural Electrification
Authors: Sitharthan R. , Madurakavi Karthikeyan , Jacob Raglend I. , Palanisamy K. , Belwin Edward J. , Rajesh M. , Dhanabalan Shanmuga Sundar
Published: July 2022

The DC Microgrid sounds familiar in recent days for its independent grid operation and energizing small communities without relying on the central grid. The sudden change in energy demand in the microgrid can negatively impact its performance and operation. Energy management is the only optimal solution to the energy production of microgrids. This article -discusses an economically operated DC microgrid for rural electrification with a tri-port converter based on the radial basis function neural network (RBFNN)-based intelligent control strategy to provide enhanced performance to the microgrid. The advantage of the proposed system is that it provides optimal energy management solutions during dynamic loading conditions and enhances the operation of the microgrid. The outstanding aspect of the proposed system is that it boosts the conversion operation and effectively manages the battery energy storage system to supply energy to the domestic loads and supply power to the grid during excess power generation. In the assessment, the rural regions of Tamilnadu and Andhra Pradesh, India, have been considered to enhance the microgrid setup. The performance evaluation of the proposed system has been conducted and validated using an experimental setup. The assessment also discusses the economic and environmental analysis in using the proposed system. The results support the performance and efficiency of the proposed model.
Tree-Related Microhabitats Are Promising Yet Underused Tools for Biodiversity and Nature Conservation: A Systematic Review for International Perspectives
Authors: Martin Maxence , Paillet Yoan , Larrieu Laurent , Kern Christel C. , Raymond Patricia , Drapeau Pierre , Fenton Nicole J.
Published: July 2022

Sustainable management of forest ecosystems requires the use of reliable and easy to implement biodiversity and naturalness indicators. Tree-related microhabitats (TreMs) can fulfill these roles as they harbor specialized species that directly or indirectly depend on them, and are generally more abundant and diverse in natural forests or forests unmanaged for several decades. The TreM concept is however still recent, implying the existence of many knowledge gaps that can challenge its robustness and applicability. To evaluate the current state of knowledge on TreMs, we conducted a systematic review followed by a bibliometric analysis of the literature identified. A total of 101 articles constituted the final corpus. Most of the articles (60.3%) were published in 2017 or after. TreM research presented a marked lack of geographical representativity, as the vast majority (68.3%) of the articles studied French, German or Italian forests. The main themes addressed by the literature were the value of TreMs as biodiversity indicators, the impact of forest management on TreMs and the factors at the tree- and stand-scales favoring TreMs occurrence. Old-growth and unmanaged forests played a key role as a “natural” forest reference for these previous themes, as TreMs were often much more abundant and diverse compared to managed forests. Arthropods were the main phylum studied for the theme of TreMs as biodiversity indicators. Other more diverse themes were identified, such as restoration, remote sensing, climate change and economy and there was a lack of research related to the social sciences. Overall, current research on TreMs has focused on assessing its robustness as an indicator of biodiversity and naturalness at the stand scale. The important geographical gap identified underscores the importance of expanding the use of the TreMs in other forest ecosystems of the world. The notable efforts made in recent years to standardize TreM studies are an important step in this direction. The novelty of the TreM concept can partially explain the thematic knowledge gaps. Our results nevertheless stress the high potential of TreMs for multidisciplinary research, and we discuss the benefits of expanding the use of TreMs on a larger spatial scale.