bluuebunny/crossref_metadata_2025 huggingface dataset:
The Seeds of the Mexican Countryside
Authors: Bautista-Ramírez Edgardo , González-Santos Rosalinda
Published: September 2024

Objective: The objective of this work is to make an analysis of the types of seeds use by Mexican farmers and their relationship with Local Seed Systems (SLS) and Formal Seed Systems (SFS).
Design/methodology/approach: The work consisted of a bibliographic review about the types of seeds available for the Mexican countryside and their seed systems. In addition, to identify some priorities and strategies for its strengthening.
Results: In Mexico, derived from its climatic, edaphic, geophysical heterogeneity, cultural social and economic diversity. It has caused both landraces and improved seed to coexist in the SLS and SFS. However, there is a predominance in the use of landraces in SLS of 70 to 80 %. Therefore, it is considered a priority to conserve traditional selection, management, conservation and use practices that have caused the wide inter- and intraspecific diversity of landraces. However, more research needs to be carried out and its legal framework strengthened. In the case of improved seeds located mainly in SFS, it is considered to promote their use in vegetables and the ornamental sector.
Limitations on study/implications: The work developed could be complemented with the participation and interviews of decision makers in seed policies in Mexico and the review of processed in other countries.
Findings/conclusions: In Mexico the use of native and improved seeds coexists. To satisfy the demand for food, all types of seeds are important and both the SLS and the SFS but differentiated public policies are required for their attention and the definition of a specific legal framework for landraces.
A mixed-effects height-diameter model for Pinus douglasiana Martínez in temperate forests of Jalisco, Mexico
Authors: Xelhuantzi-Carmona Jaqueline , Corral-Rivas Sacramento , Barrera-Ramírez Rubén , Muñoz-Flores Hipólito J. , Rubio-Camacho Ernesto A.
Published: September 2024

predicting tree-height of Pinus douglasiana in the natural forests of Jalisco, Mexico.
Design/methodology/approach: For this study, we utilized 2,921 pairs of tree-height measurements collected from 65 permanent plots (each 50x50 m) in the study area. For each plot, we estimated the tree density as the number of trees per hectare (N, ha-1), the basal area per hectare (G, m2 ha-1) and the quadratic mean diameter (dg, cm). Subsequently, we tested several models from the literature and developed a generalized mixed-effects model for tree height prediction.
Results: The Gompertz base model outperformed the other local models, achieving an R² of 0.75 and an RMSE of 3.13. Including the stand variables (N, G, and dg) and incorporating random effects significantly improved the model fit, resulting in an R² of 0.89 and an RMSE of 2.09 m. Calibration and validation steps revealed that selecting the three thickest trees is effective for estimating random effects in new plots or stands, with the RMSE and R² being 2.59 and 0.83, respectively.
Limitations on study/implications: The present model can be applied in areas where P. douglasiana is naturally distributed. However, it is advisable to calibrate the model using a sub-sample to achieve more accurate predictions of tree heights in new plots or areas.
Findings/conclusions: The Gompertz function was used as the base function to develop the final generalized mixed-effects model for predicting the height of Pinus douglasiana. The inclusion of stand variables (N, G, and dg) along with random effects improved the model fit. This model represents a new and more accurate tool for predicting the height of P. douglasiana in areas where it is naturally distributed.
Actores, actantes y redes. Representación mediática de la acción colectiva en un conflicto socioambiental peruano
Authors: Mendoza Michilot María
Published: September 2024

El artículo analiza la representación periodística de los protagonistas en el conflicto peruano de Las Bambas; es un estudio de caso, de diseño integrado, que combina la observación de las agendas y de los frames con el análisis de las redes que se atribuyen a actores y actantes. Se encontró que la confrontación es por tópicos no necesariamente socioambientales, y que el enfoque principal es la asignación de responsabilidad del Gobierno y de la comunidad. El debate gira en torno al proyecto empresarial minero, nodo que concentra la acción de las partes y debe preservarse a pesar de todo.
Identifying the Factors Influencing Youths Decision in Afghanistan for the Purpose of Smartphone Purchasing
Authors: Abdul Zohoor Mudaber  , Mohammad Arash Hamyar  , Spingul Mayar  , Amir Mohammad Jahed
Published: September 2024

The current study aims to investigate the variables influencing customer intent to purchase smartphones and to smooth the way and increase investor interest in investing in Afghanistan considering the identified factors (Subjective Norm, Personal Factor, Operational Factor, Software Performance, and Product Physical Features). Data was collected through a Google Forms structured questionnaire, which was developed from previous studies, using a 5-point Likert scale. This study determined that a sample size of 800–1000 respondents would be appropriate for the survey; 892 replies in all were gathered. The factor analysis test was applied to test the variables' validity. In the study, Binary Logistic Regression Analysis (LR) was performed to assess whether there is a significant relationship between smartphone purchasing decisions and the following factors: Subjective Norm, Personal Factor, Operational Factor, Software Performance, and Product Physical Features. The research showed that there is a significant relationship between the mentioned factors and smartphone purchase decisions. There are a variety of elements that influence consumers' intentions to buy smartphones, but subjective norms, personal factors, operational factors, software performance, and physical features are the factors that drive consumers to purchase.
دراسة تحليليه للسياحة الرياضية في العراق من وجهة نظر الرواد
Authors: Asst. Lec. Marwa Alaa Hussein  , ,  Prof. Dr. Sondos Musa Jawad
Published: September 2024

للسياحة الرياضية دورا بالغة الأهمية في تطوير النشاط السياحي، وذلك لكونه منهجا علميا لتنظيم وإدارة النشاط السياحي بجميع عناصره وأنماطه، فهو يوفر إطار عمل مشترك لاتخاذ القرارات في إدارة الموارد السياحة ويزود الجهات المسئولة بالأساليب والاتجاهات التي يجب أن تسلكها، مما يسهل عملها ويوفر كثيرا من الجهد الضائع بالإضافة إلى زيادة ممارسة الأنشطة الرياضية التنافسية,  ويهدف البحث الى اعداد مقياس السياحة الرياضية في العراق من وجهه نظر الرواد التعرف على مقياس السياحة الرياضيه في العراق من وجهه نظر الرواد وتحديد مستويات معياريه المقياس واستخدمت الباحث مقياس السياحة الرياضيه يتكون من (21) فقرة وكان عدد العينة (50) الرواد في العراق من حيث توصلت الباحثتان الى عدد من الاستنتاجات والتوصيات أهمها: يعد المقياس الحالي اداه للكشف عن مستوى كفايات تخطيط السياحة الرياضية في العراق. نشر الوعي السياحي بواسطة وسائل الاتصال المرئية والمسموعة والمقروءة المختلفة من تلفاز واذاعه وصحافه وانترنت.
أثر تمرينات بدنيـــة مهارية بأسلوب الثابت والمتحرك في تعلم مهارة الارسال والاعداد في تنس كرة القدم
Authors: Asst. Lec. Yasser Shahid Abdul Rahman  , Asst. Lec.  Bakr Basil Kamel  , Asst. Lec. Wathiq Shaker Mahmoud
Published: September 2024

يهدف البحث الى إعداد تمرينات بدنية مهارية خاصة بالأسلوب الثابت والمتحرك في تعلم مهارة الارسال والاعداد في تنس كرة قدم ويفترض الباحثون وجود فرق ذو دلالة إحصائية بين الاختبارين القبلي والبعدي في تعلم مهاره الارسال والاعداد بتنس كرة القدم لعينة البحث. واستخدم الباحثون المنهج التجريبي بتصميم المجموعتين المتكافئة لملاءمته لطبيعة ومشكلة البحث. أما عينة البحث فتكونت من لاعبين نادي شهربان الرياضي لفئة الناشئين لسنة 2022 البالغ عددهم (16) تم اختيارهم بطريقة عمدية، وقد قسم على مجموعتين تجريبية وضابطة بطريقة القرعة كل مجموعة مكونة من (8) حيث شكلت النسبة المئوية 80%من مجتمع البحث للعام 2022. وبعد الانتهاء من التجربة الرئيسية استخدم الباحثون برنامج (spss) لأجراء المعالجات الاحصائية والوصول الى النتائج.
تأثير تمرينات خاصة في بعض المتغيرات البايوكينماتيكية لمرحلتي الحجلة والخطوة وانجاز الوثبة الثلاثية للطلاب
Authors: Ali Nasser Jassim  , Asst.  Prof. Dr. Abeer Ali Hussein  , Prof. Dr. Nadia Shaker Jawad3
Published: September 2024

هدف البحث إلى أعداد تمرينات خاصة وادرجها في القسم الرئيسي من الوحدات التعليمية والتعرف على اثر تلك التمرينات الخاصة في تطوير بعض المتغيرات البايوكينماتيكية المختارة (وزاوية الانطلاق وسرعة الانطلاق وارتفاع نقطة الانطلاق) وانجاز لطلاب المرحلة الثانية (2024-2023) استخدم الباحثون (المنهج التجريبي) بتصميم المجموعتين المتكافئتين (الضابطة والتجريبية) وحدد الباحثون مجتمع البحث بطلاب المرحلة الثانية لجامعة كربلاء لسنة -2023)2024( وعددهم (120) طالب ومقسمين الى اربع شعب وهي (A,B,C,D) وتم اختيار شعبتين منها و بالطريقة العشوائية البسيطة (القرعة) لتمثل عينة البحث الرئيسية وهي (60) طالب اذ مثلت شعبة (C) المجموعة التجريبية بواقع (31) طالب  وشعبة (A) المجموعة الضابطة بواقع(32) طالب وقام الباحثون بأعداد تمرينات الخاصة لكل متغير وتم ادراجها في الوحدات التعليمية في التجربة الرئيسية التي تضمنت (10) وحدات تعليمية تم تطبيقها بواقع وحدتين تعليميتين في الأسبوع وبواقع خمسة أسابيع وكان زمن الوحدة التعليمية (65 دقيقة) تنوعت فيها التمرينات لغرض تحسين المستوى الرقمي لفعالية الوثبة الثلاثية للطلاب،واستخدام الحقيبة الإحصائية (Spss), وان اهم ما استنتجه الباحثون ان التمرينات الخاصة كان لها اثر في تطوير المتغيرات البايوكينماتيكية (وزاوية الانطلاق وسرعة الانطلاق وارتفاع نقطة الانطلاق) والمستوى الرقمي (الإنجاز) للمجموعة التجريبية وان المجموعة التجريبية التي استخدمت التمرينات الخاصة كان لها الأفضلية في تطوير المتغيرات البايوكينماتيكية المختارة والمستوى الرقمي (الإنجاز) للفعالية من المجموعة الضابطة .
أثر تمرينات الفارتلك التصاعدي في تطوير مهارتي اليوروستيب والفلوترشوت بكرة السلة للاعبين الشباب
Authors: Asst. Lec. Laith Ezzat Issa
Published: September 2024

يعد إتقان المهارات من أهم الموضوعات التي تشغل المعنيين باللعبة وقد بات من المسلمات ان رفع المستوى التدريبي لأي لاعب لا يمكن النهوض به سواء أكان بدنيا وخططيا ام نفسيا دون تعلم الأداء الفني لجميع المهارات الأساسية والمركبة للعبة حيث تشتمل على كل المفردات ذات الواجبات المختلفة والتي تؤدى في أطار قانون اللعبة سواء أكانت بالكرة ام بدونها وتعد مدى إجادة أفراد إي فريق لكافة أشكال المهارات الأساسية من أهم العوامل التي تؤدي إلى النجاح والتفوق. وتتميز اللعبة بالإيقاع السريع والتحول من الدفاع الى الهجوم بسرعة شديدة وكذلك انطلاقات مفاجئة سواء كانت بالكرة أم بدونها والتوقف غير المتوقع والوثب والدورانات وتغيير الاتجاهات ونقل الحركة وفقا لأحداث المباراة كل هذه الأمور تتطلب إجادة تامة لجوانب الأداء الفني بدون استخدام الكرة وفي ساحات صغيرة نسبيا مما يجعل للاعب فرصة اكبر في استلام الكرة وكذلك تسجيل إصابة من هذا لا يمكن إغفال تلك المهارات كونها أساس اللعب ويعتمد عليها في أمور التحرك الجماعي للفريق (التكتيك) وتطور هذه المهارات تحتاج إلى تدريبات بأساليب حديثة ومتطورة وتراعي متطلبات اللعبة البدنية والمهارية  وطريقة الفارتلك التصاعدي تعد من الطرائق التدريبية التي تلائم تطور هذه المهارات بشكل فعال لما تمتاز به من ديناميكية في  إيقاع أنظمة أنتاج الطاقة في إطارها المختلط مع تزايد نسب مساهمة نظام حامض اللاكتيك بسبب تسارع الأداء في المباريات ومن هذه الأهمية الكبيرة للمهارات الهجومية.
PENGARUH PERENCANAAN ANGGARAN DAN KUALITAS SDM TERADAP PENYERAPAN ANGGARAN
Authors: Linda A.O Tanor  , Sianipar Cia Selviana , Lonto Miryam P.
Published: September 2024

Penelitian ini dilakukan dengan tujuan untuk mengkaji dan menilai pengaruh perencanaan anggaran dan kualitas sumber daya manusia terhadap penyerapan anggaran. Populasi studi ini melibatkan seluruh pegawai negeri sipil yang bertugas di kantor biro ekonomi setda provinsi sulut. Dengan menggunakan Metedologi Penelitian Kuantitatif dan teknik sampel jenuh, 41 orang termasuk dalam sampel. Hasil penelitian menyatakan bahwa perencanaan anggaran berpengaruh negatif dan signifiikan terhadap penyerapan anggaran, dan kualitas sumber daya manusia berpengaruh positif dan signifikan terhadap penyerapan anggaran. Perencanaan anggaran dan kualitas sumber daya manusia keduanya berkontribusi secara bersama sama kepada penyerapan anggaran. Analisis regresi linear berganda digunakan sebagai teknik analisis dalam penelitian ini.
Giải pháp xanh hoá xuất khẩu thép Việt Nam: Thích ứng trước tác động của Cơ chế Điều chỉnh Biên giới Carbon của Liên minh Châu Âu
Authors: Ngô Thị Phương Thảo
Published: September 2024

Theo Cơ chế điều chỉnh biên giới carbon được Liên minh Châu Âu ban hành vào 10/5/2023, từ năm 2026, thuế carbon dựa trên lượng khí phát thải sẽ áp dụng cho các sản phẩm xuất khẩu, đặc biệt gây áp lực cho các doanh nghiệp cần xanh hóa sản phẩm. Ngành thép, với sản lượng xuất khẩu sang Liên Minh đạt 1,5 triệu tấn trong Quý 1 năm 2024, dự báo sẽ chịu ảnh hưởng lớn. Nghiên cứu sử dụng chủ yếu phương pháp phân tích định tính để đánh giá thực trạng và tiềm năng xuất khẩu thép Việt Nam vào Liên minh Châu Âu, đồng thời dự báo các thách thức từ Cơ chế điều chỉnh biên giới carbon, đặc biệt là yêu cầu giảm phát thải để tránh rào cản thương mại. Từ đó, bài báo đề xuất giải pháp tăng cường năng lực chính sách và đẩy nhanh quá trình xanh hóa ngành thép Việt Nam nhằm thích ứng với quy định mới của Liên minh Châu Âu.
Adenomatoid Tumor Case Report: An Unusual Intraoperative Finding of Peritoneal Deposits Revealing Adenomatoid Tumor Anomaly
Authors:   General Surgery Resident, Department of General Surgery, Mubarak Al-Kabeer Hospital, Kuwait City 00965, Kuwait, Alansari Mohammad Waleed , Alshammar Qayrawan ,   General Surgery Resident, Department of General Surgery, Mubarak Al-Kabeer Hospital, Kuwait City 00965, Kuwait, Hindi Khaled ,   https://orcid.org/0000-0002-7562-979X
Published: September 2024

Adenomatoid tumors are non-cancerous growths that arise from mesothelial cells and typically affect the reproductive organs of both men and women. Nonetheless, documented cases have shown occurrences in other locations such as the adrenals, liver, pleura, and peritoneum. Identifying an adenomatoid tumor in these areas poses a significant diagnostic challenge due to their infrequency. In most instances, patients do not display symptoms, and the deposits are incidentally discovered during surgery for other medical conditions. We present the case of a 36-years-old male who presented with symptoms of incarcerated hernia and underwent urgent laparoscopic hernia repair, during which multiple deposits were incidentally discovered. Subsequent histopathological examination confirmed benign mesothelial cell proliferation consistent with benign adenomatoid tumor
Cíngulos incisais pronunciados em incisivos superiores: Relato de caso com abordagem conservadora
Authors: Abrante Bruno Lucena Antunes , Munhoz Luciana , Freitas Cláudio Fróes de
Published: September 2024

Este estudo relata o caso clínico de uma paciente de 28 anos que procurou atendimento odontológico na Unidade Básica de Saúde (UBS) Jardim Farina, em São Bernardo do Campo, para exodontia de terceiros molares. Durante o exame clínico e radiográfico, foi observado um achado raro: cíngulos incisais pronunciados em forma de garras nos dentes 11, 21, 12 e 22. A radiografia panorâmica revelou áreas radiopacas associadas a essas projeções anatômicas. Embora a condição seja incomum, a paciente optou por não realizar tratamento restaurador estético, já que não se incomodava com sua estética. Este estudo detalha as características clínicas e radiográficas da condição, revisa a literatura relevante e discute as implicações da escolha pelo manejo conservador.
Ptolemaios’un Pers Karşıtı Tutumunun Tarihi Bellek Perspektifinden Kökenleri
Authors: Öncü Fariz
Published: September 2024

Pers İmparatorluğu’na son veren Büyük İskender (III. Aleksandros) MÖ 323 tarihinde Babil’de hayata gözlerini yumduğunda onun kurduğu imparatorluğun bütünlüğü de tehlikeye girmişti. Zira İskender’in kendinden sonra kimin tahta geçeceğini açık olarak işaret etmemesi imparatorluk topraklarının nasıl yönetileceği hususunda büyük tartışmaların yaşanmasına yol açmıştı. Meselenin tarafları İskender’in daha sonra Diadokhoi (Ardıllar) olarak bilinecek kıdemli generalleriydi. Her biri farklı politik hedeflerle hareket eden generaller bazen II. Philippos’la soy bağı kurmaya çalışarak bazen de Büyük İskender’in politik mirasını sahiplenerek kendi pozisyonlarını meşru göstermeye çalışıyorlardı. Ancak Pers karşıtı tarihsel referanslar üzerinden söylem geliştirerek siyaset yapanlar da vardı. Bunlardan en bilineni I. Ptolemaios Soter idi. Onun Persleri “öteki” olarak gösteren tutumu İskender’in ölümünden hemen sonra yeni kralı belirlemek amacıyla gerçekleşen Babil Toplantısında alınan kararları önemli ölçüde etkilemişti. Ptolemaios Mısır’da satrap olarak hanedanlığını meşru bir zeminde kurumsallaştırmaya çalıştığı süreçte de Pers karşıtı tarihi belleği kullanmıştı. Bu politik tutumun dönemin reel politiğinde büyük bir etki yaratması Perslerin Hellen ve Mısırlılar ile kurduğu yaklaşık iki yüzyıllık ilişkinin sorunlu yanlarıyla ilgiliydi.
Dolayısıyla Pers karşıtı tarihi belleğin uzun erimli gelişim sürecinin incelenmesi Ptolemaios’un politik yaklaşımının farklı bir boyutuyla anlaşılmasını sağlayacaktır. Çalışmamız bu noktadan hareketle, diğer çalışmalardan farklı olarak, Ptolemaios’un hem Babil Toplantısında hem de Mısır’da benimsediği Pers karşıtı politik tavrını, Akhaimenid İmparatorluğu’nun ilk dönemlerinden itibaren kritik politik süreçlerde araçsallaştırılan Pers karşıtı bellek üzerinden irdelemeyi amaçlamaktadır.
Some Notes on Aeolian Neonteichos and Temnos
Authors: Atcı Esra
Published: September 2024

According to Herodotus, the Aeolians, who migrated to the coast of Western Anatolia in waves, established 12 cities in the region. Among these, Neonteichos and Temnos played key roles in terms of geostrategic importance, especially during the rule of the Pergamon Kingdom. These settlements later became strongholds during Persian attacks. However, Neonteichos, situated between the cities of Temnos and Larisa, did not have a significant presence in historical events and is therefore rarely mentioned in ancient sources. The fact that the raw material for the coins minted in Neonteichos was copper indicates the city's passive development, as it remained overshadowed by its neighboring cities. Neonteichos was initially founded as a military base to capture Larisa, which hindered its growth into a well-established urban center. In contrast, Temnos gained a well-deserved reputation as a garrison city frequently mentioned in historical geography. Its strategic position overlooking the Hermos River, the absence of powerful nearby cities, and its location on important routes from the coast to the interior positively influenced its economy. Additionally, the city was the center of worship for the cult of Apollo Kynneios, which elevated its status to a level that could rival the city of Gryneion, a key city of the Aeolian League.
This article analyzes the developmental trajectories of Neonteichos and Temnos—cities for which there is little comprehensive information in historical sources and which have not been sufficiently studied in modern literature due to the lack of archaeological research—focusing on their socio-cultural, economic, and political dimensions.
Tarihsel ve Coğrafi Dönüşüm Sürecinde Sumerli dKubaba ve dLama
Authors: Yıldırım Nurgül
Published: September 2024

Eskiçağ dünyasında tanrı ve tanrıçalara atfedilen kudretin kaynağı bulunulan coğrafya, siyasi koşullar ve göç sonucu yeni topraklardaki inanç sisteminin devamlılığıyla şekillenmiştir. Dolayısıyla tanrı ve tanrıçalar, sembolleriyle birlikte, tapınım gördükleri halkların yalnızca kültürel değil siyasi ve ekonomik açıdan da tanımlanmalarına olanak sağlamıştır. Mezopotamya’dan ulaşılan çivi yazılı kayıtlar bereket algısının adlandırılması açısından veri sağlarken, Anadolu’da bu kültün temellerine ilişkin arkeolojik bulgular neredeyse yerleşik yaşamın ilk evrelerine tarihlenmiştir. Anadolu’da gelişen Ana Tanrıça inancı ve bu inanca ilişkin somut yansımalarda yalnızca dişil gücün ön planda olduğu belirlenirken, Mezopotamya’daki bereket kültüne ilişkin öncül kayıtlar tanrı ve tanrıça çiftleri üzerinden işlenmiştir. Bereketin, bolluğun ve refahın kaynakları ve koruyucuları olan bu kutsal çiftler tapınım gördükleri halklarca farklı adlandırılmıştır. Mezopotamya’da başlayan bu geleneksel yaklaşımın Anadolu ve Doğu Akdeniz coğrafyası yazım geleneğindeki karşılıkları, Tanrıça KUBABA ve Tanrı LAMA örneği üzerinden değerlendirilerek bu çalışmada ele alınmış, çalışmanın temel kaynaklarını ilgili tanrı ve tanrıça adlarının özellikle birlikte kaydedildiği Erken ve Orta Demir Çağı kayıtları oluşturmuştur.
EXPLORING THE ECONOMIC IMPACT OF SMART CITY INVESTMENT: A LITERATURE REVIEW
Authors: Febiyanti Widyantari , Subriadi Apol Pribadi
Published: September 2024

The current implementation of smart cities aims to enhance the quality of life for their communities. Smart city investments can be achieved through collaborative efforts between information and communication technology and human resources, transforming areas into sustainable cities. Many countries are becoming increasingly interested in smart city investments. However, it remains unclear how these investments can achieve their intended goals. The primary issue lies in the lack of effective methodologies to measure the economic impact of such investments. Many cities lack comprehensive assessment tools to gauge the economic impact of smart city implementations, making it difficult to determine whether these investments deliver the desired benefits. This article aims to provide references regarding the economic impacts of smart city investments and the frameworks that can be used to measure them. The methodology employed in this research is a literature review based on references published over the past five years. According to findings, smart city investments have been found to impact aspects such as e-commerce and e-business, the creation of environmentally friendly environments, cost savings and economic benefits, GDP growth, and increased income for regions/cities through effective smart city utilization. Several frameworks have been gathered to measure economic impact, such as Computable General Equilibrium (CGE), Energy Efficient Integrated Planning Framework (EEIPF), and Open Data Impact for Smart Cities Framework (ODISC). Each framework serves to illustrate how examples of smart city investments can influence the economy of a region or city.
GAME DEVELOPMENT PROJECT MANAGEMENT USING SCRUM FRAMEWORK: HYPERCASUAL GAME CASE STUDY 'RUSH RUNNER'
Authors: Nurjaman Moh. , Baturohmah Habi , Warman Cecep
Published: September 2024

The research aims to explore and implement an effective Project Management approach in Game Development using the Scrum Framework. A case study was conducted on the development of a hypercasual game titled "Rush Runner." With a focus on rapid iterations, continuous feedback, and adaptation to changes, the Scrum methodology was used to manage the game development workflow from planning to publication. Concrete steps were taken to adapt to user needs and evolving demands as an integral part of the development process. The research findings indicate that the implementation of Scrum had a positive impact on productivity, quality, and user satisfaction in hypercasual game development. Furthermore, the integration of Project Management and the Scrum approach optimized overall time, cost, and quality. These findings provide valuable insights for practitioners and researchers in the field of game development to understand the importance of an adaptive and responsive Project Management approach to market changes and user needs.
LOGISTICS SERVICE INFORMATION SYSTEM AUDIT USING COBIT 5 FRAMEWORK
Authors: Hayat Husnul , Samudi Samudi
Published: September 2024

KBN Prima Logistik is a subsidiary affiliated with PT. Kawasan Berikat Nusantara which operates in the field of logistics services. In carrying out its business processes, it has implemented an Information System in the form of using desktop-based supporting business applications (Client Server). Some of the current problems are that the applications used are not functioning optimally, IT Governance procedures are not well defined by standards, there is no IT Division in the Organizational Structure that is responsible for IT management and there is a shortage of competent human resources in the IT field. Therefore, it is necessary to measure the Maturity Level and Capability Level of IT governance. So, research was carried out using the COBIT 5 framework as an Information System Audit model. The research method goes through the stages of problem identification, literature study, and domain determination which focuses on the DSS and MEA domains. The data collection method was through interviews and distributing questionnaires filled in by 20 respondents. The research results show that the Maturity Level value in the DSS and MEA domains shows an average value of 1.94 or 194%. Capability Level is still at Level 2 (Managed Process) from the expected Target Level 3 (Established Process). This indicates that although the IT processes has been run and implemented regularly with planning and monitoring according to business process objectives, but the management is not yet optimal and not well standardized. The results of the gap assessment show that the average gap value is 1.06.
COMPARISON LINEAR REGRESSION AND RANDOM FOREST MODELS FOR PREDICTION OF UNDERGROUND DROUGHT LEVELS IN FOREST FIRES
Authors: Alamsyah Nur , Budiman Budiman , Yoga Titan Parama , Alamsyah R Yadi Rakhman
Published: September 2024

The increase in forest fires poses a significant risk due to its impact on underground dryness, which can cause long-term environmental damage and challenge fire suppression efforts. This research aims to develop a prediction model for underground drought levels in the context of forest fires using machine learning techniques. The methodology used in this research follows the CRISP-DM (Cross-Industry Standard Process for Data Mining) framework, which includes the stages of business understanding, data understanding, data preparation, modeling, evaluation, and deployment. This study analyzes a forest fire dataset, applies encoder labels to transform categorical variables, and uses linear regression and random forest models to predict underground drought levels. The goal is to create a predictive model that can help inform wildfire risk management strategies by anticipating underground drought levels. The results showed that the random forest model achieved higher prediction accuracy than the linear regression, with an R-squared value of 0.97. This suggests that the random forest model is a more robust tool for predicting underground drought levels, providing valuable insights for forest fire management. This research contributes to the understanding of underground drought levels, aiding the development of effective wildfire risk management strategies.
Safety and efficacy of HK-660S in patients with primary sclerosing cholangitis: A randomized double-blind phase 2a trial
Authors: Paik Woo Hyun , Park Joo Kyung , Chung Moon Jae , Huh Gunn , Park Ce Hwan , Lee Sang Hyub , Jeong Heon Se , Kim Hee Jin , Park Do Hyun
Published: September 2024

Background/Aims: A clinical unmet need persists for medications capable of modulating the progression of primary sclerosing cholangitis (PSC). This study aimed to assess the clinical feasibility of HK-660S (beta-lapachone) in PSC.Methods: In this multicenter, randomized, double-blind, placebo-controlled, parallel-group phase 2 trial, participants were assigned in a 2:1 ratio to receive either 100 mg of HK-660S or a placebo twice daily for 12 weeks. The primary outcomes were the reduction in serum alkaline phosphatase (ALP) levels and the percentage of participants showing improvements in PSC severity, as determined by magnetic resonance cholangiopancreatography with the Anali score. Secondary endpoints included changes in liver stiffness and adverse events.Results: The analysis included 21 patients, 15 receiving HK-660S, and six receiving a placebo. Improvements in the Anali score were observed in 13.3% of the HK-660S group, with no improvements in the placebo group. HK-660S treatment resulted in a 15.2% reduction in mean ALP levels, compared to a 6.6% reduction in the placebo group. A stratified ad-hoc analysis based on baseline ALP levels showed a statistically significant response in the HK-660S group among those with ALP levels greater than twice the upper limit of normal, with a 50% responder rate (p=0.05). Additionally, 26.7% of the HK-660S group showed improvements in the enhanced liver fibrosis score, with no improvements in the placebo group. HK-660S was generally well tolerated.Conclusions: HK-660S is well tolerated among patients with PSC and may improve bile duct strictures, decrease serum ALP levels, and reduce liver fibrosis (cris.nih.go.kr, Number KCT0006590).
Quantifying the fates and retention of larval rockfish through Lagrangian analyses
Authors: Quigley LA , Franks PJS , Thompson AR , Field JC , Santora JA
Published: September 2024

Understanding larval transport pathways and retention is important for fisheries management and predicting recruitment variability. We investigated how mesoscale circulation patterns influence the retention and dispersal of larval rockfish Sebastes spp. within the California Current System off the western coast of the USA. Using a 25 yr record of satellite-derived geostrophic and Ekman velocity fields, Lagrangian particle tracking simulations were implemented to find pathways of passively drifting virtual particles representing rockfish larvae. Statistical fates of particles were averaged to reveal mean spatial and temporal patterns in retention and distance traveled. Yearly retention values were compared to observed pelagic juvenile rockfish abundance collected on annual surveys. Retention patterns varied spatially throughout the region, with the Southern California Bight emerging as a highly retentive region. Interannual variability in overall retention was positively related to the abundance of pelagic juvenile rockfish collected in the same year. Our analyses provide evidence supporting the successful implementation of the geographic placement of the Cowcod Conservation Areas, which were spatial closures implemented in the early 2000s to rebuild overfished rockfishes, and illustrate the utility of numerical simulations for understanding the retention and transport of pelagic larvae such as rockfish.
Peroxyredoxin 6 Protects RIN-M5F Pancreatic Beta Cells Against Streptozotocin-Induced Senescence
Authors:   Institute of Cell Biophysics, FSC PBCRAS, Institutskaya str., 3, Pushchino, Moscow region, Russia, 142290, Novoselova Elena G. , Parfenyuk Svetlana B.
Published: September 2024

Background/Aims: There are evidences that a decrease in the functional activity of pancreatic β-cells under type 2 diabetes conditions may be associated with their senescence, therefore, senotherapy may be a prospective strategy for the diabetes treatment. Methods: The senotherapeutic potential of peroxiredoxin 6 (PRDX6) was studied in RIN-m5F pancreatic β-cells with streptozotocin-induced senescence by measuring markers, associated with senescence. Results: Exposure to streptozotocin (STZ) resulted in the senescence of the β-cells. The addition of PRDX6 to the culture medium of RIN-m5F β-cells before treatment with STZ decreased the levels of the following senescence markers: the percentage of SA-β-Gal-positive cells, the phosphorylation of histone H2AX and p21 proteins, and the secretion of the proinflammatory cytokine IL-6 but not the anti-inflammatory cytokine IL-10. These effects were accompanied by a decrease in the production of reactive oxygen species (ROS) and the restoration of impaired NF-κB activation. In addition, PRDX6 altered the production of the heat shock protein HSP90: the production of the constitutive form of HSP90-beta decreased, while the level of inducible HSP90-alpha increased. Conclusion: PRDX6 prevented the senescence of RIN-m5F cells in response to the DNA damage-inducing agent streptozotocin, indicating a potential protective role of PRDX6 in type 2 diabetes mellitus.
The Night Sweats and Pulmonary Embolism-controversial Presentation and Differentiation
Authors: Naeem Azka , Tamazyan Vahagn , Khan Muhammad Hashim , Shetty Vijay
Published: September 2024

Pulmonary embolism (PE) is a common and potentially fatal condition where early and accurate diagnosis can significantly reduce mortality and morbidity. It typically presents with a range of associated symptoms such as breathlessness at rest or during exertion, coughing, discomfort or swelling in the legs, and wheezing. However, many atypical symptoms are also possible, including epigastric pain, hypotension, and night sweats, with mechanisms not yet understood. The absence of definitive signs and symptoms makes diagnosing pulmonary embolism challenging. We report the case of a 56-year-old male who presented to the ER with right-sided chest pain following laparoscopic umbilical and bilateral inguinal hernia repair 6 days prior. Workup revealed a PE, for which the patient was started on apixaban. Following the initiation of apixaban, the patient developed drenching night sweats, which, after extensive workup, were determined to be a diagnosis of exclusion.
Blastomycosis: An Underrecognized Climate Sensitive Fungal Pathogen Causing Pneumonia in 52-year-old Immunocompetent Women from Southwestern Ohio—A Case Report and Literature Review
Authors: Darwich Danny Sameh , Sabbagh Wissam , Alajati Bana
Published: September 2024

Blastomycosis, formerly known as Gilchrist disease, Chicago disease, North American blastomycosis, or Namekagos fever, is an uncommon but underappreciated fungal infection seen mostly in immunocompetent people, caused by the fungi Blastomyces. Blastomyces dermatitidis and Blastomyces gilchristii are the most common species responsible for most infections in the United States of America. Blastomycosis can cause a wide variety of diseases, the most common being pneumonia as the lungs are usually the main primary entrance source of infection after inhalation of Blastomyces spores. However, dissemination from the lungs to other organs such as skin, bones, genitourinary, and central nervous system can occur.

We describe a 52-year-old female who was admitted to the hospital for unresolved pneumonia after failure to respond to multiple outpatient antibiotic treatments for a presumed diagnosis of community-acquired pneumonia, presenting with right-sided chest pain, fever, cough and weight loss for three weeks duration. Her initial Chest-X ray and CT chest revealed right middle lobe infiltrate, while her laboratory studies were significant for elevated white blood cells (WBC). The patient underwent diagnostic bronchoscopy which showed erythema of the right middle lobe bronchus with purulent secretion. Furthermore, cytology examination of specimens from bronchoalveolar lavage and bronchial brush from right middle lobe with (PAP) satin on thin prep and H&E stain on the cell block revealed an abundance of broad-base budding yeast consistent with Blastomyces organism, which was confirmed by molecular testing with DNA probe assay. Her serum and urine Blastomyces antigens were positive, above the limit of quantification. The patient was started on antifungal therapy with Amphotericin-B intravenously. In the process, her fever resolved and her respiratory symptoms slowly improved. She was discharged home with oral itraconazole which was to be continued for 6-12 months as an outpatient.
Lyme Disease Experience Survey 2024 - All Responses Summary Posters
Authors: Murray Elizabeth , Cruikshank Anne , Husain Zahra , Lawrence Nicola
Published: September 2024

Little is formally documented on the lived experience of Lyme disease - the state of diagnosis, treatment & care and the impact on the lives of those infected. Lyme Resource Centre (LRC) conducted an online survey to gather information on the impact of Lyme disease on those directly affected in the United Kingdom & Republic of Ireland. The survey responses are summarised and presented here.
Highly concentrated collagen/chondroitin sulfate scaffold with platelet-rich plasma promotes bone-exposed wound healing in porcine
Authors: Li Zhihao , Li Qian , Ahmad Akhlaq , Yue Zhongjie , Wang Hongxia , Wu Guofeng
Published: September 2024

In the case of wounds with exposed bone, it is essential to provide not only scaffolds with sufficient mechanical strength for protection, but also environments that are conducive to the regeneration of tissues and blood vessels. Despite the excellent biocompatibility and biodegradability of collagen and chondroitin sulfate, they display poor mechanical strength and rapid degradation rates. In contrast to previous methodologies that augmented the mechanical properties of biomaterials through the incorporation of additional substances, this investigation exclusively enhanced the mechanical strength of collagen/chondroitin sulfate scaffolds by modulating collagen concentrations. Furthermore, platelet-rich plasma (PRP) was employed to establish optimal conditions for vascular and tissue regeneration at the wound site. High-concentration collagen/chondroitin sulfate (H C-S) scaffolds were synthesized using high-speed centrifugation and combined with PRP, and their effects on endothelial cell proliferation were assessed. A porcine model of bone-exposed wounds was developed to investigate the healing effects and mechanisms. The experimental results indicated that scaffolds with increased collagen concentration significantly enhanced both tensile and compressive moduli. The combination of H C-S scaffolds with PRP markedly promoted endothelial cell proliferation. In vivo experiments demonstrated that this combination significantly accelerated the healing of porcine bone-exposed wounds and promoted vascular regeneration. This represents a promising strategy for promoting tissue regeneration that is worthy of further exploration and clinical application.
Quantitative real time PCR for distinction between Pneumocystis jirovecii infection/colonization in hospitalized patients
Authors: Rouhi Faezeh , Erami Mahzad , Rastgufar Sepide , Jahani Maryam , Aboutalebian Shima , Soltani Sajedeh , Fakhim Hamed , Mirhendi Hossein
Published: September 2024

Background

Identification of the opportunistic fungus Pneumocystis jirovecii in respiratory specimens presents challenges, particularly in differentiating between colonization and active infection. The present study assessed a probe-based real time PCR (qPCR) diagnostic effectiveness in patients with diverse underlying conditions, particularly those with COVID-19 and pulmonary insufficiency.

Methods

To set up the qPCR, clinical samples from 281 patients with respiratory ailments were tested. Subsequently, a descriptive study was conducted on 112 patients with pulmonary insufficiency with and without COVID-19 suspected of P. jirovecii infection. All specimens were subjected to DNA extraction followed by nested PCR and qPCR targeting the mitochondrial large subunit (mtLSU)-rRNA gene.

Results

Based on nested PCR and qPCR, P. jirovecii was identified in 40 out of 281 patients, with slight variations in positive samples observed across dilutions. Three patients who tested positive in nested PCR yielded negative results in probe-based qPCR. Conversely, three patients who tested positive in probe-based qPCR yielded negative results in nested PCR. Considering nested PCR as the golden standard, probe-based qPCR demonstrated good diagnostic performance, with 92.5% sensitivity and 98.7% specificity. Based on cycle threshold (Ct) values, the positive cases were categorized: ≤32 as infection, >35 as colonization, and a grey zone between these values (32 < X ≤ 35). The analysis of 112 PCP-suspected patients revealed a prevalence ranging from 6.25% (nested PCR) to 7% (probe-based qPCR).

Conclusions

This study suggested Ct values to differentiate Pneumocystis pneumonia/colonization in immunocompromised patients. To further augment the diagnostic sensitivity, it is recommended to integrate qPCR results with clinical parameters and biomarkers to offer a more precise understanding of Pneumocystis-related conditions.
Causal relationship between fertility nutrients supplementation and PCOS risk: a Mendelian randomization study
Authors: Shao Fang , Xu Shijia , Zhao Haiyang , Zhang Furong , Wang Xin , Wang Hui
Published: September 2024

Background

Polycystic ovary syndrome (PCOS), a prevalent endocrine disorder in women of reproductive age, is mainly ameliorated through drugs or lifestyle changes, with limited treatment options. To date, numerous researchers have found that fertility nutrient supplements may benefit female reproductive health, but their direct impact on polycystic ovary syndrome risk remains unclear.

Methods

Our research employs Mendelian Randomization to assess how fertility nutrients affect PCOS risk. Initially, we reviewed 49 nutrients and focused on 10: omega-3 fatty acids, calcium, dehydroepiandrosterone, vitamin D, betaine, D-Inositol, berberine, curcumin, epigallocatechin gallate, and metformin. Using methodologies of Inverse Variance Weighting and Mendelian Randomization-Egger regression, we examined their potential causal relationships with PCOS risk.

Results

Our findings indicate omega-3 fatty acids reduced PCOS risk (OR=0.73, 95% CI: 0.57-0.94, P=0.016), whereas betaine increased it (OR=2.60, 95% CI: 1.09-6.17, P=0.031). No definitive causal relations were observed for calcium, dehydroepiandrosterone, vitamin D, D-Inositol, and metformin (P>0.05). Drug target Mendelian Randomization analysis suggested that increased expression of the berberine target gene BIRC5 in various tissues may raise PCOS risk (OR: 3.00-4.88; P: 0.014-0.018), while elevated expressions of curcumin target gene CBR1 in Stomach and epigallocatechin gallate target gene AHR in Adrenal Gland were associated with reduced PCOS risk (OR=0.48, P=0.048; OR=0.02, P=0.018, respectively).

Conclusions

Our research reveals that specific fertility nutrients supplementation, such as omega-3 fatty acids, berberine, and curcumin, may reduce the risk of PCOS by improving metabolic and reproductive abnormalities associated with it.
Enhanced biodegradation of trinitrotoluene in rhizosphere soil by native grasses
Authors: Li Na , Yang Kenny , Lin Chungho , Yang John
Published: September 2024

Soil contamination by the munition explosive residues of 2,4,6-trinitrotoluene (TNT) and its metabolites resulting primarily from military operations has been identified as a threat to human health and ecosystems. Biodegradation by native plants to remove this hazardous compound or reduce its toxicity is considered a cost-effective and environmentally sound approach for the cleanup or restoration of TNT-contaminated soils. This study aims to investigate the TNT biodegradation and kinetics by two selected native grasses in the species-specific rhizosphere soils through growth chamber experiments. Native eastern gamma grass (Tripsacum dactyloides) and switchgrass (Panicum virgatum L.) were grown in soil spiked with 14C-TNT for 8 weeks. The 14C-TNT degradation and degradative metabolite profile in the rhizosphere soils were determined by liquid scintillation counter and high-performance liquid chromatography, respectively. The results indicated that both native grass species significantly enhanced the TNT degradation in the rhizosphere soils as compared with the control rhizosphere soils. More than 95% of the applied 14C-TNT was degraded in the first 7 days, and the rate then reached a steady state afterward, but less than 10% of the TNT applied was completely mineralized and transformed into CO2. The degradative reaction was found to follow second-order kinetics. Six major TNT degradative metabolites have been detected and identified in the rhizosphere soils. Overall, switchgrass appeared more effective for biodegrading TNT than eastern gamma grass. This research demonstrated that the native grass species, especially switchgrass, has the potential to mitigate the adverse human health and ecological risks of TNT-contaminated sites and can be considered an environmentally friendly, sustainable approach to safeguarding human health from TNT contamination.
Temporal dynamics of acoustic diversity in managed forests
Authors: Müller Sandra , Jahn Olaf , Jung Kirsten , Mitesser Oliver , Ammer Christian , Böhm Stefan , Ehbrecht Martin , Farina Almo , Renner Swen C. , Pieretti Nadia , Schall Peter , Tschapka Marco , Wells Konstans , Scherer-Lorenzen Michael
Published: September 2024

Introduction

In production forests, management can have cascading effects on biodiversity and ecosystem services. Acoustic diversity reflects the diversity of vocalizing animals and has also considerable recreational value for human well-being, but the relationship between acoustic diversity and forest management remains largely unexplored

Method

We recorded acoustic diversity on forest plots along a gradient of silvicultural management intensity (SMI) in three regions of Germany. We explored the diurnal and seasonal temporal dynamics in acoustic diversity index (ADI) from March to July using generalized additive mixed models (GAMMs). We further investigated the interrelation between acoustic diversity and silvicultural management intensity, forest structural diversity, as well as tree diversity, bird species richness and abundance using structural equation modeling (SEM).

Results

Silvicultural management intensity had significant effects on the temporal dynamics of ADI in May and June from dawn till dusk, but variance explained by SMI was low. We confirmed our hypothesis that ADI was reduced by SMI due to its cascading effects on forest structural diversity and bird species richness and abundance.

Discussion

Acoustic diversity indices can provide valuable insights into how forest management affects the acoustic activity of soniferous communities. We discuss how this can indicate both changes in species diversity as well as their vocal activity. We further address potential implications for forest management.
Association of beta blockers and mortality in adults with septic shock: systematic review and meta-analysis of randomized clinical trial
Authors: Vásquez-Tirado Gustavo Adolfo , Quispe-Castañeda Claudia Vanessa , Meregildo-Rodríguez Edinson Dante , Cuadra-Campos María , Segura-Plasencia Niler Manuel , Arbayza-Avalos Yessenia Katherin , Alva-Guarniz Hugo Nelson , Guzmán-Aguilar Wilson Marcial , Zavaleta-Alaya Petterson
Published: September 2024

Introduction

Septic shock still entails significant morbidity and mortality, with the heart being affected due to catecholamine overexpression and direct injury from sepsis. Therefore, the effect of β-blocking the receptors to improve performance is promising when attempting to reverse tachycardia and reduce mortality.

Methods

We conducted a comprehensive search across five databases for studies published up to 28 January 2024, using a PICO strategy. Ten studies were identified for quantitative analysis and included in our meta-analysis.

Results

Our meta-analysis evaluated 28-day in-hospital mortality risk across nine randomized controlled trials (RCTs) involving a total of 1,121 adults with septic shock. We found an association between β-blocker use and reduced overall mortality (OR 0.57; 95% CI 0.34–0.98; I2: 56%). This effect was significant in the esmolol subgroup (OR 0.47; 95% CI 0.26–0.82; I2: 32%), but not in the landiolol subgroup (OR 0.98; 95% CI 0.0–1,284.5; I2: 72%). Additionally, the intervention group shows a significant reduction in HR and lactate levels, as well as an increase in stroke volume index (SVI).

Conclusion

In adults with septic shock, β-blockers are associated with a reduction in 28-day in-hospital mortality, a benefit primarily observed with esmolol rather than landiolol. Furthermore, improvements in heart rate (HR) control, lactate levels, and SVI were noted. However, these findings should be interpreted with caution, and further high-quality RCTs comparing different β-blockers are necessary to better elucidate these effects.

Systematic review registration

https://www.crd.york.ac.uk/prospero/, identifier CRD42024513610.