bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of Novel Plant Peroxisomal Targeting Signals by a Combination of Machine Learning Methods and in Vivo Subcellular Targeting Analyses
Authors: Lingner Thomas , Kataya Amr R. , Antonicelli Gerardo E. , Benichou Aline , Nilssen Kjersti , Chen Xiong-Yan , Siemsen Tanja , Morgenstern Burkhard , Meinicke Peter , Reumann Sigrun
Published: April 2011

In the postgenomic era, accurate prediction tools are essential for identification of the proteomes of cell organelles. Prediction methods have been developed for peroxisome-targeted proteins in animals and fungi but are missing specifically for plants. For development of a predictor for plant proteins carrying peroxisome targeting signals type 1 (PTS1), we assembled more than 2500 homologous plant sequences, mainly from EST databases. We applied a discriminative machine learning approach to derive two different prediction methods, both of which showed high prediction accuracy and recognized specific targeting-enhancing patterns in the regions upstream of the PTS1 tripeptides. Upon application of these methods to the Arabidopsis thaliana genome, 392 gene models were predicted to be peroxisome targeted. These predictions were extensively tested in vivo, resulting in a high experimental verification rate of Arabidopsis proteins previously not known to be peroxisomal. The prediction methods were able to correctly infer novel PTS1 tripeptides, which even included novel residues. Twenty-three newly predicted PTS1 tripeptides were experimentally confirmed, and a high variability of the plant PTS1 motif was discovered. These prediction methods will be instrumental in identifying low-abundance and stress-inducible peroxisomal proteins and defining the entire peroxisomal proteome of Arabidopsis and agronomically important crop plants.
Regulation of the adaptor molecule LAT2, an in vivo target gene of AML1/ETO (RUNX1/RUNX1T1), during myeloid differentiation
Authors: Duque‐Afonso Jesús , Solari Leticia , Essig Aitomi , Berg Tobias , Pahl Heike L. , Lübbert Michael
Published: April 2011

The leukaemia‐specific fusion oncoprotein RUNX1/RUNX1T1 (AML1/ETO), resulting from the chromosomal translocation (8;21) in acute myeloid leukaemia (AML), imposes a striking genotype–phenotype relationship upon this distinct subtype of AML, which is mediated by multiple, co‐ordinate downstream effects induced by this chimeric transcription factor. We previously identified the LAT2 gene, encoding the adaptor molecule LAT2 (NTAL, LAB), which is phosphorylated by KIT and has a role in mast cell and B‐cell activation, as a target of the repressor activity of RUNX1/RUNX1T1. These results were confirmed and extended by demonstrating downregulation of the LAT2 protein in response to conditional RUNX1/RUNX1T1 expression, and its absence in primary AML with the t(8;21). In contrast, in a cohort of 43 AML patients, higher levels of LAT2 were associated with myelomonocytic features. Differentiation of HL‐60 and NB4 cells towards granulocytes by all trans‐retinoic acid (ATRA) resulted in downregulation of LAT2; conversely, it was upregulated during phorbol ester‐induced monocytic differentiation of HL‐60 cells. Forced expression of LAT2 in Kasumi‐1 cells resulted in a striking block of ATRA‐ and phorbol ester‐induced differentiation, implicating disturbances of the graded expression of this adaptor molecule in the maturation block of myeloid leukaemia cells.
Role of immune responses in the pathogenesis of low‐risk MDS and high‐risk MDS: implications for immunotherapy
Authors: Aggarwal Shikhar , van de Loosdrecht Arjan A. , Alhan Canan , Ossenkoppele Gert J. , Westers Theresia M. , Bontkes Hetty J.
Published: April 2011

The myelodysplastic syndromes (MDS) constitute a group of heterogeneous clonal haemopoietic stem cell disorders, characterized by ineffective and dysplastic haematopoiesis with varying degrees of peripheral cytopenia. Low‐risk MDS is characterized by increased apoptosis in the bone marrow (BM) with autoimmune characteristics whereas the advanced or high‐risk stages involve immune evasion and secondary DNA damage, giving cells growth potential to progress into acute myeloid leukaemia (AML). Nevertheless, the causes of MDS remain poorly defined and it is not clear how the disease progresses from an early stage to advanced MDS and AML. Although there are clear indications for a role of the immune system, the exact mechanism by which the immune response contributes to the progression is not yet clear. New insights into the pathophysiology of MDS with regard to the immune system will be instrumental for the development of novel patient‐oriented therapies. This review is focused on the role of immune responses in MDS and the implications for the development of novel immune therapies.
Importance of B cell co-stimulation in CD4+ T cell differentiation: X-linked agammaglobulinaemia, a human model
Authors: Martini H , Enright V , Perro M , Workman S , Birmelin J , Giorda E , Quinti I , Lougaris V , Baronio M , Warnatz K , Grimbacher B
Published: April 2011

We were interested in the question of whether the congenital lack of B cells actually had any influence on the development of the T cell compartment in patients with agammaglobulinaemia. Sixteen patients with X-linked agammaglobulinaemia (XLA) due to mutations in Btk, nine patients affected by common variable immune deficiency (CVID) with <2% of peripheral B cells and 20 healthy volunteers were enrolled. The T cell phenotype was determined with FACSCalibur and CellQuest Pro software. Mann–Whitney two-tailed analysis was used for statistical analysis. The CD4 T cell memory compartment was reduced in patients with XLA of all ages. This T cell subset encompasses both CD4+CD45RO+ and CD4+CD45RO+CXCR5+ cells and both subsets were decreased significantly when compared to healthy controls: P = 0·001 and P < 0·0001, respectively. This observation was confirmed in patients with CVID who had <2% B cells, suggesting that not the lack of Bruton's tyrosine kinase but the lack of B cells is most probably the cause of the impaired CD4 T cell maturation. We postulate that this defect is a correlate of the observed paucity of germinal centres in XLA. Our results support the importance of the interplay between B and T cells in the germinal centre for the activation of CD4 T cells in humans.
No causal relationship between Yersinia enterocolitica infection and autoimmune thyroid disease: evidence from a prospective study
Authors: Effraimidis G , Tijssen J G P , Strieder T G A , Wiersinga W M
Published: April 2011

The objective of this study was to evaluate prospectively the relationship between Yersinia enterocolitica (YE) infection and the development of overt autoimmune hypo- or hyperthyroidism (study A) and the de novo occurrence of thyroid antibodies (study B). This was a prospective cohort study of 790 euthyroid women who were first- or second-degree relatives of autoimmune thyroid disease (AITD) patients. Follow-up was 5 years, with annual assessments. Study A was a nested case–control study in which YE serological status was measured between cases {subjects who developed overt hypothyroidism [thyroid stimulating hormone (TSH) > 5·7 mU/l and free T4 (FT4) < 9·3 pmol/l] or overt hyperthyroidism (TSH < 0·4 mU/l and FT4 > 20·1 pmol/l)} and matched controls. For study B, 388 euthyroid women without thyroid antibodies at baseline were enrolled. The YE serological status was compared between subjects who developed thyroid peroxidase (TPO)-antibodies and/or thyroglobulin (Tg)-antibodies at 4-year follow-up and those who remained negative. For study A, the proportion of subjects positive for Yersinia enterocolitica outer membrane protein (YOP) immunoglobulin (Ig)G or YOP IgA did not differ between cases and controls at baseline. One year before the development of overt hypo- or hyperthyroidism, the proportion of subjects with YOP IgG was not different between cases and controls, but YOP IgA were less prevalent in cases. For study B, de novo occurrence of TPO (or TPO-antibodies and/or Tg-antibodies) did not differ between subjects in whom YOP IgG were positive or negative at baseline. Neither persistence nor emergence of YOP IgG at 4-year follow-up was associated with the occurrence of TPO-antibodies or Tg-antibodies. Similar results were observed with respect to YOP IgA. YE infection does not contribute to an increased risk of thyroid autoimmunity.
Inflammatory stress exacerbates hepatic cholesterol accumulation via increasing cholesterol uptake and de novo synthesis
Authors: Zhao Lei , Chen Yaxi , Tang Renkuan , Chen Yao , Li Qing , Gong Jianping , Huang Ailong , Varghese Zac , Moorhead John F , Ruan Xiong Z
Published: April 2011

Background and Aim:  Cholesterol accumulation plays an important role in the progression of non‐alcoholic fatty liver disease. We have demonstrated that inflammation aggravated cholesterol accumulation, causing tissue injury in the vessel and kidney. This study was undertaken to investigate whether inflammatory stress exacerbates hepatic cholesterol accumulation and we explored the underlying mechanisms.

Methods:  We used casein injection in C57BL/6J mice, interleukin‐1β and interleukin‐6 stimulation in human hepatoblastoma cell line (HepG2) cells to induce inflammatory stress. Oil Red O staining and intracellular cholesterol assay were used to quantify cellular cholesterol levels. Real‐time reverse transcription polymerase chain reaction and Western blot were used to measure messenger RNA (mRNA) and protein expression of target genes. HMGCoA reductase (HMGCoA‐r) enzymatic activity and cellular cholesterol synthesis were measured by radioactive methods.

Results:  We demonstrated that inflammatory stress increased hepatic cholesterol accumulation and enhanced sterol regulatory element binding protein 2 (SREBP2), low‐density lipoprotein receptor (LDLr) and HMGCoA‐r mRNA and protein expression in livers of C57BL/6J mice and in HepG2 cells. A high‐fat diet in mice or LDL loading in HepG2 cells inhibited mRNA and protein expression of these genes. However, the suppressive effect was overridden by inflammatory stress both in vivo and in vitro. Inflammatory stress increased HMGCoA‐r enzymatic activity and cellular cholesterol synthesis in HepG2 cells in the absence or presence of LDL loading.

Conclusion:  Inflammatory stress disrupted hepatic SREBP2‐mediated low‐density lipoprotein receptor and HMGCoA‐r feedback regulation resulting in exacerbated cholesterol accumulation in livers of C57BL/6J mice and HepG2 cells.
Incidence of lymphoceles after robot‐assisted pelvic lymph node dissection
Authors: Orvieto Marcelo A. , Coelho Rafael F. , Chauhan Sanket , Palmer Kenneth J. , Rocco Bernardo , Patel Vipul R.
Published: April 2011

Study Type – Therapy (case series)

Level of Evidence 4

What’s known on the subject? and What does the study add?

Lymphocele formation after open pelvic lymph‐node dissection is a known complication. However, reported incidences using the robotic approach are unclear and likely underestimated. The present study aims to better understand the true incidence of lymphocele formation after RARP.

OBJECTIVE

• To determine the incidence and predictive factors of lymphocele formation in patients undergoing pelvic lymph node dissection (PLND) during robot‐assisted radical prostatectomy (RARP).

PATIENTS AND METHODS

• Between April and December 2008, 76 patients underwent PLND during RARP for ≥cT2c, prostate‐specific antigen level ≥10, Gleason score ≥7 prostate cancer.

• All patients were prospectively followed up with pelvic computed tomography 6–12 weeks after the procedure.

• All patients received s.c. heparin preoperatively and postoperatively. PLND was limited to zones 1 and 2 as defined by Studer.

• Plasma‐kinetic bipolar forceps were used for haemostasis during PLND.

RESULTS

• At a mean follow‐up of 10.8 weeks, 51% (39/76) of patients had developed a lymphocele. Of these 39 lymphoceles 32 (82%) were unilateral and seven (18%) were bilateral.

• The mean (range) lymphocele size was 4.3 × 3.2 (1.5–12.3) cm; 41% of lymphoceles were <4 cm, 53.9% were 4–10 cm, and 5.1% were >10 cm in diameter. Six of the 39 lymphoceles (15.4%) were clinically symptomatic. The symptoms were as follows: pelvic pressure in five patients, abdominal distension with ileus in three patients, leg pain/weakness in one patient and costovertebral tenderness in one patient. Two lymphoceles required intervention.

• On the logistic regression model the presence of nodal metastases, tumour volume in the prostate specimen and extracapsular extension (ECE) were independent risk factors for the development of a lymphocele.

• There was no correlation between estimated blood loss, body mass index, pathological Gleason score or number nodes dissected and the presence of lymphocele.

CONCLUSIONS

• The incidence of lymphoceles was higher than anticipated given the believed protective effect of the transperitoneal approach against lymphocele formation.

• The risk of lymphocele seemed to increase linearly with the presence of more extensive disease, particularly ECE and nodal involvement.

• The benefit of PLND during RARP should be weighed against the elevated risk of lymphocele formation and its potential complications.
Once Bitten: The Effect of IMF Programs on Subsequent Reserve Behavior
Authors: Bird Graham , Mandilaras Alex
Published: April 2011

Traditional models have encountered problems in explaining the accumulation of international reserves, particularly in Asia, in the period since the late 1990s. One suggestion has been that countries have sought to self‐insure against future crises, either because of a perceived increase in the cost of crises or because of the perceived conditionality costs of using IMF credits. This paper offers an empirical investigation of these ideas, disaggregating across regions and across IMF facilities. We find that IMF programs have had a significant positive effect on subsequent reserve accumulation, allowing for other determinants, and that this effect endures over time. We also find that the effect differs between Latin America and Asia, and that it is not simply a phenomenon that is associated with the Asian crisis of 1997/98. The paper goes on to discuss the implications for the design of policy and for the reform of the IMF.
Nonlinearity between Trade Openness and Economic Development
Authors: Kim Dong‐Hyeon , Lin Shu‐Chin , Suen Yu‐Bo
Published: April 2011

This paper utilizes the instrumental variable threshold regressions approach to reassess the trade–development link. It finds evidence that trade openness contributes to uneven development. Greater trade openness tends to have beneficial effects on real development of high‐income countries. For low‐income ones, however, trade openness appears to influence real income in a significant and negative way. The data also reveal that greater trade openness has a positive effect on capital accumulation, productivity growth, and financial development in high‐income countries, but a negative impact in low‐income ones.
Vertical Foreign Direct Investment versus Outsourcing: A Welfare Comparison from the Perspective of a Host Country
Authors: Goswami Arti Grover
Published: April 2011

In the offshoring literature, there is a huge disconnect between the alternative modes of organizing offshore production and their relative welfare impact on a host country. We bridge this gap by comparing the welfare of a host country from vertical foreign direct investment (VFDI) vis‐à‐vis international outsourcing. Our model finds that the ability to maximize welfare in the alternative modes of organizing offshore production is contingent on the absorptive capacity of the host country. If a host country's absorptive capacity is above a critical threshold, outsourcing is more welfare enhancing vis‐à‐vis VFDI; while even with an absorptive capacity lower than this critical threshold, outsourcing being welfare improving over VFDI cannot be ruled out.
Banking Sector Performance in Latin America: Market Power versus Efficiency
Authors: Chortareas Georgios E. , Garza‐Garcia Jesus G. , Girardone Claudia
Published: April 2011

Since the mid‐1990s the banking sector in the Latin American emerging markets has experienced profound changes due to financial liberalization, a significant increase in foreign investments, and greater merger activities often occurring following financial crises. The wave of consolidation and the rapid increase in market concentration that took place in most countries has generated concerns about the rise in banks' market power and its potential effects on consumers. This paper advances the existing literature by testing the market power (Structure–Conduct–Performance and Relative Market Power) and efficient structure (X‐ and scale efficiency) hypotheses for a sample of over 2500 bank observations in nine Latin American countries over 1997–2005. We use the Data Envelopment Analysis technique to obtain reliable efficiency measures. We produce evidence supporting the efficient structure hypotheses. The findings are particularly robust for the largest banking markets in the region, namely Brazil, Argentina, and Chile. Finally, capital ratios and bank size seem to be among the most important factors in explaining higher than normal profits for Latin American banks.
Symmetric or Asymmetric Interest Rate Adjustments? Evidence from Southeastern Europe
Authors: Karagiannis Stelios , Panagopoulos Yannis , Vlamis Prodromos
Published: April 2011

The purpose of this paper is to examine how effectively the wholesale interest rates are transmitted to the retail rates and whether the interest rate passthrough is symmetric or asymmetric in Greece, Bulgaria, and Slovenia. The disaggregated general‐to‐specific methodology is applied for testing the symmetry hypothesis in these economies. It is evident from our results that variations exist across the countries examined regarding the monetary transmission process and the symmetry hypothesis alike. This can be interpreted as an indication of a different level of competition, development, and liberalization among the banking systems in these Southeastern European economies.
The British ‘failure’ that never was? The Anglo‐American ‘productivity gap’ in large‐scale interwar retailing—evidence from the department store sector1
Authors: SCOTT PETER , WALKER JAMES
Published: April 2011

Interwar British retailing has been characterized as having lower productivity, less developed managerial hierarchies and methods, and weaker scale economies than its US counterpart. This article examines comparative productivity for one major segment of large‐scale retailing in both countries—the department store sector. Drawing on exceptionally detailed contemporary survey data, we show that British department stores in fact achieved superior performance in terms of operating costs, margins, profits, and stock‐turn. While smaller British stores had lower labour productivity than US stores of equivalent size, TFP was generally higher for British stores, which also enjoyed stronger scale economies. We also examine the reasons behind Britain's surprisingly strong relative performance, using surviving original returns from the British surveys. Contrary to arguments that British retailers faced major barriers to the development of large‐scale enterprises, that could reap economies of scale and scope and invest in machinery and marketing to support the growth of their primary sales functions, we find that British department stores enthusiastically embraced the retail ‘managerial revolution’—and reaped substantial benefits from this investment.
The two sterling crises of 1964: a comment on Newton
Authors: OLIVER MICHAEL J.
Published: April 2011

In a recent article in this journal, Newton claimed that there were two sterling crises in the autumn of 1964 and that the government response to the second crisis followed a ‘textbook reaction’. This comment challenges both suggestions and argues that there was one sterling crisis and that the government did not deal with the crisis adequately.
Natural Rights to Welfare
Authors: Van Duffel Siegfried
Published: April 2011

Abstract:Many people have lamented the proliferation of human rights claims. The cure for this problem, it may be thought, would be to develop a theory that can distinguish ‘real’ from ‘supposed’ human rights. I argue, however, that the proliferation of human rights mirrors a deep problem in human rights theory itself. Contemporary theories of natural rights to welfare are historical descendants from a theory of rights to subsistence which was developed in twelfth‐century Europe. According to this theory, each human being has a special role to fulfil in God's plan and therefore has inalienable rights to subsist. Later theories have secularized this idea by claiming that human beings are purposive agents. Secularization, however, comes at a price. In the case of these theories, the price is a failure to provide satisfactory answers to the most basic questions we would expect of a theory of natural rights to answer. They have failed to provide a basis for ascribing these rights to all and only to human beings. They have not been able to generate a clear and viable criterion for ascribing duties correlative to these rights. And they cannot limit rights‐claims in a non‐arbitrary way. Hence we should abandon these theories.
Lesbian, Gay and Bisexual Equality in a Modernizing Public Sector 1997–2010: Opportunities and Threats
Authors: Colgan Fiona , Wright Tessa
Published: April 2011

The public sector has traditionally been in the forefront of equality employment policy and practice and an employer of choice for lesbian, gay and bisexual (LGB) people. The introduction of the Employment Equality (Sexual Orientation) Regulations outlawing discrimination in employment on grounds of sexual orientation in 2003 has undoubtedly offered a step forward for LGB people in British workplaces. Yet the public sector has been subjected to huge changes as a result of the ‘modernization agenda’ pursued by the Labour government between 1997 and 2010. It has been argued that the pace and direction of change has not only jeopardized but reversed progress made on equal opportunities in the public sector. This article considers LGB employee and trade union representatives' views on the inclusion of sexual orientation in public sector equality policy and practice. It draws on European Social Fund‐sponsored research in nine ‘good practice’ public sector organisations between 1994 and 1997.
THE PROBLEM OF ALIEN IMMIGRATION INTO GREAT BRITAIN, ILLUSTRATED BY AN EXAMINATION OF RUSSIAN AND POLISH JEWISH CHILDREN
Authors: PEARSON KARL , MOUL MARGARET
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A PEDIGREE OF EPICANTHUS AND PTOSIS
Authors: USHER C. H.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
ON THE RELATIVE VALUE OF THE FACTORS WHICH INFLUENCE INFANT WELFARE
Authors: Anderson A. G. , Evans Wm. Arnold , Greenwood Alfred , Pilkington H. O. , Tattersall C. H.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
ON THE INTERRELATIONSHIP OF CERTAIN CHARACTERS IN MAN (MALES)
Authors: RUGER HENRY A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A CO‐OPERATIVE STUDY OF THE HABITS, HOME LIFE, DIETARY AND FAMILY HISTORIES OF 450 CANCER PATIENTS AND OF AN EQUAL NUMBER OF CONTROL PATIENTS
Authors: STOCKS PERCY , KARN MARY N.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE AMOUNT OF INFORMATION SUPPLIED BY RECORDS OF FAMILIES AS A FUNCTION OF THE LINKAGE IN THE POPULATION SAMPLED
Authors: FISHER R. A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE USE OF SIMULTANEOUS ESTIMATION IN THE EVALUATION OF LINKAGE
Authors: FISHER R. A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A METHOD OF SEPARATING THE RELATIVE AETIOLOGICAL EFFECTS OF BIRTH ORDER AND MATERNAL AGE, WITH SPECIAL REFERENCE TO MONGOLIAN IMBECILITY
Authors: PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
DIE DEUTSCHE RASSENHYGIENISCHE GESETZGEBUNG IN MATHEMATISCHER BETRACHTUNG
Authors: ROLLER Dr S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
Head, Heart and Hands in Human Evolution. By R. R. Marett, M.A., D. Sc. (Oxon.), Hon.LL.D. Pp. 303. Hutchinson's Scientific Books, 1935. 10s. 6d. net
Authors: MORANT G. M.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE DETECTION OF AUTOSOMAL LINKAGE IN DATA WHICH CONSIST OF PAIRS OF BROTHERS AND SISTERS OF UNSPECIFIED PARENTAGE
Authors: PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A SEARCH FOR INCOMPLETE SEX‐LINKAGE IN MAN
Authors: HALDANE J. B. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
SELECTION BY A NEARLY PERFECT EXAMINATION
Authors: SANDON FRANK
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
TESTS OF SIGNIFICANCE APPLIED TO HALDANE'S DATA ON PARTIAL SEX LINKAGE
Authors: FISHER R. A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
NOTE ON THE DEVELOPMENT OF CORRELATIONS AMONG GENETIC COMPONENTS OF ABILITY
Authors: BARTLETT M. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
SIGNIFICANCE OF GROUPING
Authors: STEVENS W. L.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
MAXIMUM LIKELIHOOD, INVERSE PROBABILITY AND THE METHOD OF MOMENTS
Authors: JEFFREYS HAROLD
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
NOTE ON THE DISTRIBUTION OF THE THREE FORMS OF LYTHRUM SALICARIA
Authors: McGREGOR DONALD
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE DISTRIBUTION OF ENTRIES IN A CONTINGENCY TABLE WITH FIXED MARGINAL TOTALS
Authors: STEVENS W. L.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A SEARCH FOR AUTOSOMAL RECESSIVE LETHALS IN MAN
Authors: BEDICHEK SARAH , HALDANE J. B. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THREE NOMOGRAMS FOR TESTING AGREEMENT OF BLOOD GROUPING DATA WITH THEORIES OF INHERITANCE
Authors: BOYD WILLIAM C.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
OPTIMUM ESTIMATION OF FREQUENCY OF HETEROZYGOTES
Authors: NORTON H. W.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
BLOOD GROUPS IN ENGLAND
Authors: TAYLOR G. L. , PRIOR AILEEN M.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE 7 × 7 SQUARES
Authors: NORTON H. W.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
ON THE CONSTRUCTION OF BALANCED INCOMPLETE BLOCK DESIGNS
Authors: BOSE R. C.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
STUDIES IN THE CLASSIFICATION OF EYE COLOUR. II
Authors: RIDDELL W. J. B.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE FAMILIES OF THE KINGS OF SIAM OF THE HOUSE OF CHAKRI
Authors: SMITH MALCOLM
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE ANALYSIS OF A TSETSE‐FLY POPULATION. II
Authors: JACKSON C. H. N.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
The Advanced Theory of Statistics. By Maurice G. Kendall
Authors: Finney D. J.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A FURTHER NOTE ON THE SIB‐PAIR LINKAGE METHOD
Authors: PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
PEDIGREE OF NYSTAGMUS, MYOPIA AND CONGENITAL EYE DEFECTS WITH MENTAL DEFICIENCY
Authors: McGREGOR I. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A CONTRIBUTION TO THE GENETICS OF HAIR COLOUR IN MAN
Authors: LEE C. D. , PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A FACTOR ANALYSIS OF BODY MEASUREMENTS FOR BRITISH ADULT MALES
Authors: BURT CYRIL , BANKS CHARLOTTE
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
A GENETICAL FACTOR IN PERNIOSIS
Authors: HARRIS H.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE DYSGENIC EFFECT OF INDUCED RECESSIVE MUTATIONS
Authors: HALDANE J. B. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
PHENYLKETONURIA: DATA ON FORTY‐SEVEN BRITISH FAMILIES
Authors: MUNRO T. A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
NOTE ON METHODS OF ANALYSING CANCER PEDIGREES
Authors: KARN MARY N.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE MEANING OF ‘FITNESS‘ IN HUMAN POPULATIONS
Authors: PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
NOTE ON THE ELIMINATION OF INSIGNIFICANT VARIATES IN DISCRIMINATORY ANALYSIS
Authors: QUENOUILLE M. H.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE SIB‐SIB AGE OF ONSET CORRELATION AMONG INDIVIDUALS SUFFERING FROM A HEREDITARY SYNDROME PRODUCED BY MORE THAN ONE GENE
Authors: HARRIS H. , SMITH C. A. B.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE COMBINATION OF BLOOD GROUPS IN A SAMPLE OF 250 PEOPLE
Authors: SANGER RUTH , RACE R. R.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
RECOGNITION OF THE RARE RH TYPE RY IN THREE GENERATIONS
Authors: JOHNSTONE AVRIL
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
RHESUS TYPE Du
Authors: RENTON P. H. , STRATTON F.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
CONGENITAL TOTAL COLOUR BLINDNESS ASSOCIATED WITH OTOSCLEROSIS
Authors: MACGREGOR A. G. , HARRISON R.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
TASTE DEFICIENCY FOR PHENYLTHIOUREA IN AFRICAN NEGROES AND CHINESE
Authors: BARNICOT N. A.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
CONGENITAL MALFORMATIONS OF THE CENTRAL NERVOUS SYSTEM: DATA ON SIXTY‐NINE PAIRS OF TWINS
Authors: RECORD R. G. , McKEOWN THOMAS
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
ON SIMPLIFYING THE USE OF FISHER'S u‐STATISTICS IN THE DETECTION OF LINKAGE IN MAN
Authors: BAILEY NORMAN T. J.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
MEASUREMENT OF PLEIOTROPIC EFFECTS IN PHENYLKETONURIA
Authors: PENROSE L. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE GOODNESS OF FIT OF A SINGLE HYPOTHETICAL DISCRIMINANT FUNCTION IN THE CASE OF SEVERAL GROUPS
Authors: BARTLETT M. S.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
THE DISTRIBUTION OF TASTE THRESHOLDS FOR PHENYLTHIOUREA OF 384 SIB PAIRS
Authors: HARRIS H. , KALMUS H.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.
FURTHER DATA ON GENETICS OF MICROCYTHAEMIA OR THALASSAEMIA MINOR AND COOLEY'S DISEASE OR THALASSAEMIA MAJOR
Authors: BIANCO I. , MONTALENTI G. , SILVESTRONI E. , SINISCALCO M.
Published: April 2011

The articles published by the Annals of Eugenics (1925–1954) have been made available online as an historical archive intended for scholarly use. The work of eugenicists was often pervaded by prejudice against racial, ethnic and disabled groups. The online publication of this material for scholarly research purposes is not an endorsement of those views nor a promotion of eugenics in any way.