bluuebunny/crossref_metadata_2025 huggingface dataset:
Factors affecting death in COVID-19 patients with neurological disease manifestations
Authors: Okparasta Andika , Azwinda Eka
Published: September 2022

Background: Coronavirus disease-2019 (COVID-19) can also attack the nervous system besides the respiratory system. It is recorded that 25% of all COVID-19 cases are accompanied by neurological disorders with a higher death rate. The study aimed to determine the neurological manifestations of COVID-19 and analyse the factors that contribute to death in COVID-19 with neurological disorders.Methods: This was an analytical cross-sectional study that included 183 patients with COVID-19 and neurological disorders at the Department of Neurology Dr. Mohammad Hoesin Central General Hospital, Palembang, Indonesia from March 2020 to June 2021. We evaluated the risk factor for mortality in COVID-19 patients with neurological disorders.Results: In this study, 78.1% of patients were under 65 years old, and 89% were male with hypertension (51.4%) as the most comorbid disease. A total of 66.1% of the study subjects had peripheral leukocytes 10,000/mm3, with 82% having an NLR value of 3.3. The mortality rate of COVID-19 patients with neurological disorders is 30.1%. Neurological manifestations recorded were CVD (71.3%), encephalitis meningitis, seizures, exacerbation of myasthenia gravis, GBS, and myelitis. The bivariate analysis found no risk factors associated with death in COVID-19 patients with neurological disorders. Multivariate regression analysis obtained that male sex and diabetes mellitus have a correlation with death in COVID-19 accompanied by neurological disorders.Conclusions: Male COVID-19 patients with neurological manifestations and diabetes mellitus have a higher risk for death.
Comparison of infraclavicular brachial plexus block with supraclavicular brachial plexus block in upper limb surgeries using peripheral nerve stimulator
Authors: Rathod Jigishaben D. , Patel Bina B. , Patel Dipali L.
Published: September 2022

Background: The supraclavicular approach to brachialplexus block (SCB) is indicated for operations of upper extremity distal to the shoulder; the infraclavicular block (ICB) is indicated for operations of distal arm, elbow, wrist, and hand. Objective of the study was to compare the infraclavicular brachial plexus block with supraclavicular brachial plexus block in upper limb surgeries using peripheral nerve stimulator.Methods: This prospective study was conducted among 78 patients, 39 in each group in infraclavicular block and supraclavicular block, posted for various upper limb surgeries on elective or emergency basis and compare both the groups for block performance time, onset of block, quality of block, duration of block, pulse rate, mean arterial pressure post-operative complication.Results: Duration of surgery, quality of block and success rate was almost similar in both the groups. The block performance time for infraclavicular block was more as compared to supraclavicular block. The duration of block is more in infraclavicular group as compared to supraclavicular group. The onset of sensory blockade, as well as motor blockade, was slightly earlier in supraclavicular group. Hemodynemic parameters were also almost similar in both groups. Our study encounters higher number of complications among supraclavicular group.Conclusions: Supraclavicular route require less time to perform the block and have a rapid onset of sensory and motor block, but the duration of sensory and motor blockage is less as compared to infraclavicular route. Both the groups have a similar quality of block and success rate, but the supraclavicular route is associated with various complications compared to infraclavicular route.
Monitoring of hepatitis B virus surface antigen escape mutations and concomitant nucleostide analog resistance mutations in patients with chronic hepatitis B
Authors: Deshkar Smita T. , Patil Niranjan B. , Lad Ashish A. , Papal Namrata S. , Sharan Swati S.
Published: September 2022

Background: In hepatitis B virus (HBV), reverse transcriptase (RT) region of the polymerase P gene and surface S gene (HBsAg) are largely overlapped. Mutations in surface S gene may cause escape variants. In the present study, we aimed to study the prevalence and pattern of the typical HBsAg escape mutations and concomitant nucleos(t)ide analogue resistance mutation patterns in patients with chronic hepatitis B in Indian population.Methods: The present observational study was carried out from January 2021 to June 2022 with 156 known cases of hepatitis B infection. Hepatitis B viral load quantitation was done followed by HBV genotyping and drug resistance detection by PCR and sequencing.Results: Out of 156 cases of chronic hepatitis B, HBsAg escape mutations were found in 50 (32.05%) patients. Genotype D was predominant (90%). Median viral load was 4.43×105 copies/ml. Total 128 HBsAg escape mutations of 46 different patterns were observed with overall prevalence of 29.49% (46/156) in CHB infected patients. The most common substitutions were sP127T (16.67%), sA128V (14.74%), sR122K (5.13%), sY134N (3.85%), sK141R (2.56%), sS143L (2.56%) and sT126INST (1.92%). Concomitant RT mutations were detected in 20 (40%) patients. Total 68 (43.59%) RT mutations of 18 different mutation characteristics were found conferring possible or confirmed resistance to nucleos(t)ide analogues.Conclusions: The emergence of drugs resistant mutants with alteration in ‘aa’ determinant of the S protein is of some concern. The development of novel nucleos(t)ide analogues with a high barrier to resistance is warranted.  National surveillance networks should be set up.
A comparative study on obese and non-obese for evaluating the risk of hypertension
Authors: Mahmood Shaik , Rao D Santha
Published: September 2022

Obesity-associated arterial hypertension is characterized by stimulation of the sympathetic nervous system, activation of the renin-angiotensin system (RAS) and sodium retention, among other abnormalities. Stimulation of the sympathetic nervous system has been considered to have an important function in the pathogenesis of obesity-related hypertension. During the early phases of obesity, primary sodium retention exists as a result of increase in renal tubular reabsorption. Plasma renin activity, angiotensinogen, angiotensin II and aldosterone values display significant increase during obesity. Leptin and other neuropeptides are possible links between obesity and the development of hypertension. Obesity should be considered as a chronic medical condition, which is likely to require long-term treatment. Understanding of the mechanisms associated with obesity-related hypertension is essential for successful treatment strategies.
An in-vitro analysis of L-Carnitine mediated rescue of TNF-? induced apoptosis in mice oocytes
Authors: Sharma Mona , Rana Ranjana , Halder Ashutosh , Gupta Surabhi
Published: September 2022

: Tumor necrosis factor-alpha (TNF-α) is a pro-inflammatory cytokine implicated in various physiological and pathological events. Carnitine is a quaternary amine which plays a significant role in fatty acid oxidation and is reported to produce antiapoptotic effects. Aim of this work was to study the effect of L-Carnitine (LC) on TNF-α induced apoptosis in mice oocytes.

: Oocytes were isolated from super ovulated Swiss Albino mice and treated with different concentrations of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100ng/ml) and LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml). TUNEL Assay was done for the biochemical assessment of apoptosis.

: Apoptotic indices with different doses of TNF-α (0.1ng/ml, 1ng/ml, 10ng/ml, 100 ng/ml) were 28.5%, 71.4%, 100%, 42.8% respectively. The concentration of TNF-α that produced the highest apoptotic index was 10ng/ml. LC alone in different doses (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1.0 mg/ml) did not elicit any apoptotic signal. Further LC was added in different doses with 10ng/ml TNF-α to study the rate of apoptosis in mice oocytes. Apoptotic index with 10 ng/ml TNF-α and different doses of LC (0.1mg/ml, 0.3mg/ml, 0.5mg/ml, 1 mg/ml) were 25%, 37.5%, 50%, 62.5% respectively. The concentration of LC that reduced the apoptotic index to the maximum was 0.1mg/ml.

: Present study could demonstrate the anti-apoptotic effect of LC against apoptotic effects of TNF-α in mice oocytes. The study presents preliminary data suggesting a possible therapeutic role of LC in inflammatory etiologies such as ovarian failure.
Physiological and biochemical parameters of smokers and alcohol consuming adults from Terai region of Nepal using cross-sectional study
Authors: Jha Birendra Kumar , Sherpa Mingma Lhamu , Singh Jitendra Kumar , Dahal Binod Kumar , Gupta Chamma
Published: September 2022

Non-communicable chronic diseases (NCD) are contributing 46% to the global diseases burden and account for 59% of annual death. Tobacco and alcohol consumptions are reported as major factors associated with growing burden of NCDs and account for 11.5% of global death with around 80% of these deaths are reported in low middle-income countries.

Nepal, a low middle-income county, is also facing an increasing prevalence (31%) of NCDs with a significant prevalence of smoking (37.1%) and alcohol consumption (15%-57%).

To explore the physiological and biochemical parameters of smoker and alcohol consuming subjects of Terai region of Nepal.

We conducted a community based cross-sectional study during August to November 2019, 282 adult participants were selected from Terai region of Janakpur Zone, Nepal, After obtaining written consent and clinical examination, fasting venous blood was collected from study subjects and examined for triglycerides, total cholesterol, HDL-cholesterol, LDL-cholesterol and fasting blood sugar.

We observed significantly increased triglycerides (p<0.05), and waist circumference (p<0.05) in current smoking and alcohol consuming subjects, however diastolic blood pressure was found to be significantly higher among alcohol consuming subjects only (p=0.05). We did not observe any significant correlation between fasting blood sugar, total-cholesterol and LDL-cholesterol among smoking or alcohol consuming subjects.

Significantly increased triglycerides, waist circumference and diastolic blood pressure in smoking and alcohol consuming subjects likely suggest lack of public awareness and heath promotion activities in Teari region of Nepal and indicate an urgent public health awareness programs in this region to maintain quality of life.
A comparative study of serum ferritin and thyroid stimulating hormone (TSH) levels in hypothyroid and euthyroid subjects
Authors: Prabhu P S Sumitha , Cheriyan Sumina , Sulaiman Libna
Published: September 2022

Thyroid hormones synthesized and released by the thyroid gland, have a vital role in regulating the metabolism of body. Synthesis of these thyroid hormones requires an iron containing enzyme Thyroid Peroxidase (TPO). Thus, iron inadequacy can affect the proper functioning of the TPO enzyme that further affect the thyroid hormone production. Serum ferritin, an index of iron store is present in almost all cells; however, it has been reported that an alteration in ferritin levels occurs in patients with thyroid disease. This study was conducted to determine serum ferritin and Thyroid Stimulating Hormone (TSH) levels in hypothyroid and euthyroid subjects and to compare the same.

The retrospective study was carried out in Amrita Institute of Medical Sciences (AIMS), Kochi, which included 30 hypothyroid subjects as cases and 30 age and gender matched healthy controls. TSH, Thyroxine (T4) and serum ferritin levels of the study groups were collected and recorded.

The mean TSH of hypothyroid patients was found to be higher (16.12±17.00) than that of euthyroid group (2.35± 1.08) whereas the mean value of T4 (1.01± 0.25) and ferritin (43.80 ± 75.44) were found to be reduced in patients with hypothyroidism compared to normal subjects. All the parameters were statistically significant with p value <0.05.

The present study showed that hypothyroid subjects had significantly lower serum ferritin concentration than euthyroid subjects. Thus, serum ferritin measurement could be useful for the evaluation of thyroid diseases.
Study of lipid profile and insulin resistance in polycystic ovarian syndrome
Authors: Patil Vasudha Deepak , Belwalkar Gajanan , Nagane Nitin , Dhonde Sushma
Published: September 2022

Polycystic ovarian syndrome (PCOS) is the most common metabolic and endocrine disorder in women of reproductive age group. It is the first leading cause of infertility in females with incidence of 5-10%.Polycystic ovarian syndrome encloses a spectrum of clinical and metabolic diseases that are associated with cutaneous excess androgen status which includes acne resistant to treatment, hirsuitism, male or female pattern baldness, ovulatory and menstrual disturbances such as irregular bleeding, amenorrhea, oligomenorrhea, polycystic ovaries, obesity and insulin resistance.

To study lipid profile and insulin resistance in polycystic ovarian syndrome women.

The present study included 60 diagnosed PCOS women in the age group of 16-40 years. Lipid profile (TC, TG and HDL) was done on fully automatic Meril 400 biochemistry analyzer. LDLwas calculated from TC, TG and HDL cholesterol as per Friedewald calculation. Fasting plasma glucose done in semiautoanalyser and serum insulin is measured by CLAI. Insulin resistance (IR) was calculated by using HOMA model (HOMA IR).

Deranged serum lipids in the present study was mainly in the form of decreased HDL levels. Serum TC, TG and LDL levels were within normal range in most of the cases. Insulin resistance was prevalent in 75% PCOS cases in the present study.

The women with PCOS should be screened for lipid profile which can be helpful in assessing the risk of cardiovascular disease.
¿Cómo mapear y medir ecosistemas de emprendimiento? Metodología y aplicación para el ecosistema de emprendimiento innovador de Lima
Authors: Goñi Pacchioni Edwin A. , Reyes Santiago
Published: September 2022

Este documento propone, a partir de la adaptación y unificación de metodologías de análisis de redes, una herramienta de mapeo, identificación y medición de las relaciones entre actores de ecosistemas de emprendimiento. También presenta una primera aplicación de esta herramienta al ecosistema de emprendimiento de innovación en Lima, la cual arrojó cuatro conclusiones. Primero, el ecosistema ha evolucionado gradualmente, desde un estado muy embrionario en 2014 a un estado más maduro en 2018, pero aún con dependencia del financiamiento público. Segundo, el apoyo público, representado por el rol vinculador y la centralidad de Innóvate Perú, desempeñó un papel clave en la evolución del ecosistema. Tercero, existen actores centrales que emergieron en este proceso de maduración y que, al 2018, juegan roles relevantes (consultor, coordinador, guardián y vinculador). Finalmente, existe una diferenciación entre los actores en cuanto al grado de especialización según el tipo de emprendedores atendidos y servicios ofrecidos: los actores con mayor centralidad suelen brindar servicios a grupos específicos de emprendedores en etapas puntuales de su ciclo de vida. La aplicación de la herramienta al ecosistema de Lima muestra su utilidad y su potencial uso para la medición y el mapeo de otros ecosistemas de emprendimiento innovador en la región.
Effect of Seasonal Changes on Groundwater Quality in Sub-Urban Ibadan, Southwest Nigeria
Authors: Rabiu Akeem Ganiyu , Falodun Olutayo Israel , Adegboyega Dayo Amos
Published: September 2022

The purpose of the study is to assess the levels of some physicochemical parameters and heavy metals in water sources and quantify their possible impact. Household water samples that include well water (n = 80) and treated municipal water (n = 3) collected from March 2019 to March 2020 were analysed for 11 physicochemical properties using instrumentation and classical methods. The estimated water parameters were first compared with standard values for drinking water and then analysed spatially using Inverse Distance Weighting (IDW) interpolation in ArcGIS software. Water quality indices were also computed as function of the potability of the water sampled. Through this study, it was found that the well water samples were slightly acidic (pH 6.7+0.61) while the concentration of nitrate (59.38 mg/L), sulphate (294.06 mg/L), cadmium (0.03 mg/L) and lead (0.13 mg/L) were above permissible limits in drinking water - 50 mg/L, 100 mg/L, 0.003 mg/L and 0.01 mg/L, respectively. The results indicates that more than 92% of the well water samples were unfit for drinking due to elevated concentrations of nitrate, sulphate, cadmium and lead. Findings from this study suggest prioritisation of clean water provision to residents in the affected communities to avert public health emergency.
A Wavelet Neural Network-Based NARMA-L2 Feedforward Controller Using Genetic Algorithms to Control Nonlinear Systems
Authors: Mahmood Taha S. , Lutfy Omar F.
Published: September 2022

As a powerful nonlinear control design strategy, feedback linearization provides viable design tools for a wide range of nonlinear systems. This paper presents an intelligent feedback linearization design using the inverse feedforward control (IFC) scheme to control nonlinear dynamical systems. Particularly, the nonlinear autoregressive moving average (NARMA-L2) network is trained to reproduce the controlled system's forward dynamics. Consequently, the trained NARMA-L2 network can be directly employed in the IFC structure. To enhance the approximation ability of the NARMA-L2 structure, two wavelet neural networks (WNNs) are utilized to constitute the NARMA-L2 controller. Moreover, the RASP1 function was utilized as the mother wavelet function instead of the commonly employed Mexican hat function. To avoid the limitations of the gradient descent (GD) methods, the genetic algorithm has been used as the training method to optimize the NARMA-L2 inverse controller parameters. The simulation results showed that the proposed controller was effective in terms of precise control and robustness against external disturbances. Furthermore, a comparison study with other control structures revealed that the control results of the proposed WNN-based NARMA-L2 controller with the RASP1 function are superior to those of the WNN-based NARMA-L2 with the Mexican hat function, the multilayer perceptron (MLP)-based NARMA-L2 controller, and the PID controller.
Transient Stability Improvement of Multi Machine Power System Including DFIG Wind Farm Using HVDC Link
Authors: Djehaf Mohammed Abdeldjalil , Kobibi Youcef Islam Djilani , Khatir Mohammed , Ouadafraksou Mohammed
Published: September 2022

In this paper, transient stability analysis of a detailed model multi-machine power system was carried out to focus on the impact of HVDC link on system stability by comparing the critical fault clearing times of two operational scenarios, namely an AC transmission system with and without parallel HVDC transmission. The advantage and performance of AC-DC transmission for the improvement of response to transient instability caused by phase to ground fault was researched by detail simulation carried out in MATLAB/SIMULINK.
Direct and Cross-Coupling Audio-Susceptibilities of the Peak Current-Mode Controlled Independent-Input Series-Output Boost Converter
Authors: Al-Mothafar M. R. D.
Published: September 2022

This work studies the small-signal direct and cross-coupling audio-susceptibilities of the independent-input series-output boost converter with peak current-mode control. The converter functions in the continuous-conduction mode and comprises n-connected identical boost modules whose inputs are fed from separate voltage sources and outputs connected in series. Expressions for the module direct (self) and cross-coupling audio-susceptibilities are derived in symbolic form. The expressions explicitly show (n) as a variable and take into account the sampling action of the current loops. In addition, audio-susceptibilty frequency responses following the closure of the voltage feedback loops are generated and the influence of increasing n is discussed. Detailed simulations using PSIM are performed to support the analysis.
Modeling and Grid-Connected Control of Wind-Solar-Storage Combined Power Generation System
Authors: Li Hua , Tian Lixin , Zhao Lei , Wang Bo
Published: September 2022

Aiming at the complementary characteristics of wind energy and solar energy, a wind-solar-storage combined power generation system is designed, which includes permanent magnet direct-drive wind turbines, photovoltaic arrays, battery packs and corresponding converter control strategies. Simulation analysis is carried out by Matlab/Simulink platform, and the results show that the model of wind and solar storage system is correct and effective, and the grid connection control can be completed.
Stages of development of the system of additional professional education of scientific and pedagogical personnel in Russian universities
Authors:   Belgorod State University, Irkhina Irina Vitalievna , Kravets Anastasia Olegovna ,   Belgorod State National Research University
Published: September 2022

Despite the urgency of the problem of staging the development of the system of additional professional education of scientific and pedagogical personnel of Russian universities, this issue has not been sufficiently developed in scientific and pedagogical research. The prerequisites and factors of the formation of the system of additional professional education of the teaching staff in domestic universities have not been fully studied; there is no clear idea of the criteria for the allocation of stages and the essential characteristics of each of the stages of the development of the system of additional professional education of teachers. The purpose of the study is to substantiate the stages of development of additional professional education of scientific and pedagogical personnel of Russian universities from the 20s of the twentieth century to the present on the basis of historical and retrospective analysis. Methodology and methods. The methodological basis of the study was the principles of historicism, systematicity development, ideas about the universal connection and interdependence of political, economic, social and educational processes and phenomena. The research methods are: analysis of research, historical-retrospective and historical–genetic analysis of the problem under study. Results. The paper shows the relationship between the development of the system of additional professional education of scientific and pedagogical personnel of Russian universities with socio-political and economic transformations in the country. The prerequisites for the emergence of a system of additional professional education in the USSR for the teaching staff of universities from the 1920-s to 1992 are presented. The essential characteristics of the formation stage of the system under study from 2002 to 2012, as well as the stage of its further development from 2012 to the present, are emphasized and disclosed.
Self-regulation of youth volunteer activities or factors of non-participation of young volunteers in social projects
Authors:   Ural Federal University, Tarasova Anna N. , Pevnaya Maria V. ,   Ural Federal University, Fedorovna Telepaeva D. ,   Ural Federal University
Published: September 2022

The article is devoted to the conditions for the formation of the prosocial activity of the young generation in Russia. With the mobilization nature of the youth policy aimed at involving a wide range of Russian youth in mass social and cultural projects, it is important to assess the processes of self-regulation of volunteer participation in the youth environment and analyze the adaptation of young people to the mass social event agenda. The volunteer activity of young people is considered in the logic of the formation of a volunteering culture in the interaction of volunteers and organizers of social projects. The culture of volunteer participation of young Russians is analyzed through the study of how young people integrate or exclude volunteering in their life plans. The authors analyze the results of a sociological survey of young people in the Sverdlovsk region aged 14 to 24 years, conducted in 2020 (N=1105, the sample is quota). The assessments of young people and girls regarding their participation in so-cial projects, which they identify as the best and most effective, are studied. The characteristics of the organization in these projects are revealed, which influence the intentions of young volunteers to be involved in such projects and continue to volun-teering in their future. The study revealed the role of leaders and initiators of social projects, whose activity has a certain impact on the motivation and features of youth volunteer participation in social projects. According to the results of the study, the problem associated with the unwillingness of a significant part of young volunteers to take responsibility is identified, possibly associated, on the one hand, with their so-cio-psychological characteristics, on the other, with the conditions that are created during the implementation of many typical mass social projects and actions for young people as consumers of youth policy.
Fears of Russian students in a situation of social uncertainty (spring 2022)
Authors:   Ural Federal University, Pevnaya Maria V. , Shuklina Elena A. ,   Ural Federal University, Kienko Tatyana S. ,   Southern Federal University, Tarasova Anna N. ,   Ural Federal University, Andrianova Elena V. ,   University of Tyumen, Khudyakova Marina V. ,   University of Tyumen, Shapovalova Inna S. ,   Belgorod State National Research University
Published: September 2022

The article is devoted to the analysis of the repertoire of Russian students’ fears in four Russian regions in the context of the spring events of 2022. The usual and new aspects of fears and anxiety are described, as well as their regional differences due to the event context and territorial proximity/remoteness from the arena of a special mili-tary operation. Empirical data were collected among students of 1-4 full-time courses of study in economic, social and humanitarian areas of training in the Sverdlovsk, Tyumen, Rostov and Belgorod regions from 03/10/2022 to 03/15/2022. The study used the method of group focused interviews (8 focus groups). In the course of quali-tative data analysis, axial and thematic coding procedures were implemented. It was revealed that the structure of the dominant elements in the repertoire of fears is pre-served in all analyzed regions (fear of illness of relatives and friends, war, one’s own illness and loss of working capacity, arbitrariness on the part of the authorities, pov-erty), however, for students of the Urals and Siberia, the fear of illness of relatives is in the first place, while in the border regions the first position is occupied by the fear of war. It was revealed that the external environmental factors of the border areas af-fect the strengthening of fears: the closer and more real the threat is, the sharper and more specific the students' fears are. Socio-psychological tension is caused by dif-fuse, natural fears for the life, health and well-being of loved ones, one's own social future, the future of the country and the world, which, under the influence of a situa-tion of uncertainty, acquire concreteness and menacing acuteness. New aspects in the palette of fears are associated with economic, political, cultural changes in the coun-try and the world, and, first of all, with manifestations of the "cancel culture". Its economic aspect is due to the total and long-term economic sanctions against the Russian Federation, which caused a surge in economic fears, the need to cope with which will require serious changes in the economic consciousness and behavior of young people. The political aspect of cancel culture is associated among students with growing fears about the external political isolation of Russia and alienation from vari-ous forms of political activity within the country. The socio-cultural aspect of the cancellation phenomenon manifested itself in new types of fears of the cultural isola-tion of Russia as a whole, reduced access to familiar social networks and services, limited student cultural, scientific, educational exchanges and educational opportuni-ties abroad.
Aplicação da metodologia Customer Relationship Management (CRM) para a análise da satisfação percebida pelo cliente em uma empresa do setor metalomecânico
Authors: Moreira Juan Pablo Silva , Leonel Henrique Pereira , Siqueira Antonio Marcos de Oliveira
Published: September 2022

O alto cenário de competitividade imposto pela globalização, tem feito com que as organizações estejam sempre em busca por um diferencial que lhes proporcione novos recursos, ferramentas e métodos para manter e expandir seus negócios. O objetivo da presente pesquisa é de evidenciar, com o auxílio na metodologia Customer Relationship Management (CRM), a satisfação dos clientes quanto à qualidade dos sidecars fabricadas pela Empresa Alfa, viabilizando desta maneira, o processo de melhoria contínua dos produtos comercializados pela organização. Por isso, a fim de tornar a concretização visível aos colaboradores da empresa, nessa análise foi utilizado formulários de maneira descritiva e qualitativa, pois essas formas pesquisa permitem maior interação com o cotidiano da linha de produção organizacional. A partir da verificação desenvolvida ao longo desta pesquisa, tornou-se possível verificar que o objetivo de aplicação da metodologia CRM permite evidenciar, com o auxílio das opiniões do cliente, as melhorias que podem ser observadas para garantir que o produto atenda todas as necessidades dos clientes, tendo em vista que esta análise demonstrou os principais pontos de melhoria existentes na produção dos sidecars comercializados pela empresa em evidência.
Efficiency of joint glycine and auxin analogs foliar treatment on coriander seeds yield and essential oil quality
Authors: Pochuev P. V. , Romanova N. G. , Malankina E. L.
Published: September 2022

Coriander is the leading essential oil crop and occupies vast areas, both in our country and abroad, and is be used to produce linalool, with subsequent processing into other aromatic substances. Increasing its yield and quality of raw materials with the help of modern preparations is an urgent problem of essential oil production.Purpose of the work: increasing the productivity of coriander with combined use of foliar treatments with glycine and auxin-containing preparations for directed control production process in coriander seed.Material and methods. As objects for studying the effect of the drug, varieties of coriander sowing Yantar and Avangard were chosen. Plants were sown in the first or third decade of April, depending on the conditions of the year, using a SZT-3.6 seeder with row spacing of 15 cm. The seeding rate was 25 kg/ha, the seeding depth was 2 cm. concentration 10 mg/l. Drug concentrations: IAA-glycol phosphate – 25, 50 and 100 mg/l, DvaU - 2 ml/l. Treatment with a solution of IUKGF and DvaU was carried out in the phase of budding-beginning of flowering. The cutting was carried out during the period of browning of seeds on the central umbrella. The content of essential oil was determined according to SP XIV method 1.Results. As a result of the research, a positive effect of foliar treatments with glycine was revealed, both on the yield and on the content of essential oil in the raw material of coriander seed varieties Yantar and Avangard. Based on the results obtained, the effective concentration of the drug is determined not only by the characteristics of the variety, but also by weather conditions, when, depending on the conditions during the processing period and the previous harvest, different aspects of the drug action appear. The maximum increase in the collection of essential oil of coriander variety Yantar (11.1 kg/ha) was noted during the combined treatment of plants with glycine at a rate of 10 mg/l in the leaf rosette phase and IAA-GF at a rate of 50 mg/l in the budding phase; varieties Avangard (8.6 kg/ha) - with combined treatment of plants with glycine at a rate of 10 mg/l in the leaf rosette phase and DvaU at a rate of 2 ml/l in the budding phase.
C-reactive protein to albumin ratio in atrial fibrillation
Authors: ABUŞ Sabri
Published: September 2022

Objectives: Atrial fibrillation (AF) may cause thromboembolism and cardiac morbidity and mortality. Patients with cardiovascular diseases are at risk for developing AF. In this study, the relationship between inflammation markers and AF was examined.
Methods: Among 689 people followed up in the cardiology outpatient clinic for reasons such as hypertension, coronary artery disease, and rheumatic valve disease, 88 patients with AF and 601 patients without AF were compared. The blood parameters of the AF group were examined during the period when AF developed in the patients. Hemogram and biochemistry parameters of AF and non-AF groups were compared.
Results: C-reactive protein to albumin ratio (CAR), neutrophil count to albumin ratio, neutrophil count to lymphocyte count ratio, and monocyte count to lymphocyte count ratio were significantly higher in the AF group than in the non-AF group (p < 0.001, p < 0.001, p = 0.001, and p < 0.001; respectively). According to the Receiver Operating Characteristics analysis, it was found that the CAR value of cut-off: 0.0533 could diagnose AF with 74% sensitivity (AUC: 0.789, CI 95%: 0.726-0.853, p < 0.001). Albumin value of cut-off: 3.75 was found to be able to diagnose AF with 82% specificity (AUC: 0.772, CI 95%: 0.707-0.836, p < 0.001).
Conclusions: AF is an arrhythmia that should be recognized early due to the complications it causes, and the CAR value can be used in the diagnosis of AF in individuals with cardiac disease.
Robotic complexes for rolling stocks maintenance on Russian railways
Authors: Dudorov E.A. , Kudyukin V.V. , Kotova K.A.
Published: September 2022

Introducing digital technologies into the structure of Russian railways allows us to apply novel engineering solutions to rolling stock service. Russian Railways OJSC faces a technological challenge of intensifying freight transport through the railway network while maintaining process controllability and ensuring the safety level required. The solution to this problem may lie in automation and robotisation of technological processes using digital twins of infrastructure components. Digitalisation, automation and robotisation are developing into indispensable tools for the desired railway transformation. These activities enable us to increase productivity and improve service quality while allowing for flexibility in passenger and freight transport. The paper presents a case study dealing with development of a robotic system designed to ensure uninterrupted functioning of shunting yards, including automated brake release and uncoupling of railway cars transported as a train onto gravity shunting yards. We consider various design options and engineering solutions concerning the executive group of the robotic system aiming to implement the desired degrees of mobility while servicing non-determinate railway train cars.
Meine Frauenbefreiung: eine transgenerationelle Spurensuche mit einem Abstecher an eine Freudsche Mittwochsgesellschaft im Mai 1907
Authors: Rambert Bigna
Published: September 2022

Ausgehend von meiner leidenschaftlichen adoleszenten Frauenstimmrechtsmission in den frühen 60er-Jahren an einem katholischen Mädchengymnasium gehe ich auf eine historische transgenerationelle Spurensuche. Diese führt zu meiner Ur-Ur-Grossmutter mütterlicherseits, einer Frauenrechtlerin und Aktivistin der frühen bürgerlichen Frauenbewegung in der Schweiz der vorletzten Jahrhundertwende und zu ihrer Enkelin, meiner Grossmutter. Dann mache ich einen Abstecher an einen Abend der Freudschen Mittwochsgesellschaft im Mai 1907, an welchem das Thema «Weibliche Ärzte» zur Debatte steht und Freud eine verminderte Fähigkeit der Frauen zur Sublimation postuliert. Auf dem Weg über meine Mutter und meinen Vater endet meine Spurensuche mit der Geburt der Neuen Frauenbewegung im November 1968.
Statystyka i demografia w Uniwersytecie Łódzkim. Brylantowy jubileusz
Authors: Domański Czesław , Jędrzejczak Alina
Published: September 2022

The book handed over to the Readers includes the scientific, didactic and organizational achievements of statisticians and demographers of the University of Lodz. It can be treated as a continuation of the monograph entitled "Lodz academic statistics", published in 2020. The aim of the book is to present the achievements of statisticians and demographers of the University of Lodz, including precursors who have made a significant contribution to the development of statistics and demography as scientific disciplines and their wide application in many fields of knowledge. The occasion to publish this book was the 77th anniversary of the first lectures conducted by academic teachers at the University of Lodz and at the Lodz Branch of the Warsaw School of Economics. The presented scientific work covers a period of over one hundred years and has contributed to the significant development of statistics and demography in numerous higher education institutions, mainly at the University of Lodz. The Lodz community also supported other universities in Poland by promoting doctors and habilitated doctors, managing scientific projects and by organizing international conferences, including Multivariate Statistical Analysis conference, which will have its 40th edition in 2022. The book is scientific and popular science. It enriches the information on the scientific and didactic achievements of statisticians and demographers of the University of Lodz against the background of Polish, and partly also global, statistics and demography, in the process of historical development. Based on source documents, these achievements were presented against the background of Polish statistical and demographic thought ant its contribution to international statistical congresses.
Psychological review of geo-environmental factors in three Persian folk stories
Authors: Shafiei Fatemeh , Ghassemzadeh Habibollah
Published: September 2022

Cognitive narratology has been recognised as one of the most important ways of understanding human nature as expressed in the stories and narrations. In the present preliminary study, we aimed to use Turner and Fauconnier’s concepts of mental spaces and conceptual blending to explain the peculiarities of three stories belonging to three different cultural and geo-climate regions in Iran. In the present study, after collecting data from a set of texts, which included written, oral or visual, the content analysis method was used. We found some similarities among the mental spaces of different geographic regions in these three stories. They are, however, not solely influenced by environmental and cultural factors. The paper recommends that studies and investigations similar to the present one can be considered a basic but crucial step in demonstrating the extent to which a person's cognition and cognitive processing in general and the creation of meaning in particular are a continuation and representation of embodied experiences.
Keywords: Cognitive, conceptual blending, geo-environmental, narratology, storytelling
A Study on the Status of Korean Calligraphy in Toegye Yi Hwang's Calligraphy Aesthetics
Authors:   The Korean Society of Calligraphy, Jo Min-hwan
Published: September 2022

In the history of calligraphy in the Joseon Dynasty, the 16th century is meaningful in that there were various calligraphy styles besides Wang Xizhi’s calligraphy style and Zhaomengfu’s calligraphy style. Before and after Lee Hwang was alive, there were calligraphers such as Kim Gu, Seongsuchim, Hwang Gi-ro, Yang Sa-eon, and Han Ho. Each of them unfolds a variety of calligraphy styles based on their artistry, and from the perspective of calligraphy aesthetics, it is necessary to pay attention to Lee Hwang’s calligraphy aesthetics. This is because Lee Hwang understood calligraphy in the Joseon Dynasty in terms of ‘painting of the heart’ and ‘painting with calligraphy works’ based on the new Confucianism. Lee Hwang is not considered a famous calligrapher when discussing at a technical level. Lee Hwang is not considered a famous calligrapher when discussing at a technical level. The reason why Lee Hwang was established as a calligrapher is that he unfolded a world of calligraphy creation in which his knowledge and character were combined. Lee Hwang’s evaluation of calligraphy was based on ethics rather than art understood at the technical level. This tells us that Lee Hwang’s studies and art are one. The results of Lee Hwang’s calligraphy creation are evaluated as ‘stiff, robust, upright, and solemn’. Applying this to the philosophy raised by Lee Hwang, the idea that ‘when reason works, energy follows’ is a result of art. In addition, it is the result of Lee Hwang’s philosophy of ‘catch respect’. As such, Lee Hwang’s perception of art that all art should be art on which reason worked emphasizes the calligraphy trend developed by Wangxizi and others. In addition, it develops as a reason for criticizing Zhaomengfu and Zhangbi. The key to Lee Hwang’s evaluation of Zhaomengfu and Zhangbi was that they did not understand the reason properly and worked on art creation. Both Zhaomengfu and Zhangbi. belong to the failure to properly operate the calligraphic meaning of ‘the right law of the heart’ and ‘respect’ in New Confucianism. In addition, it belongs to ignoring the right law and the old law and operating it arbitrarily. If the Korean calligraphy history is identified at an aesthetic level, the calligraphy aesthetics raised at the level of ‘catch respect’ and ‘picture of the mind’ presented a typical example of calligraphy aesthetics that Confucian scholars of the Joseon Dynasty later sought. In this regard, there is a historical significance in Korean calligraphy.
BASIC PRINCIPLES OF ODONTOPREPARATION F O R N ON -REMOVABLE O RTHOPEDIC STRUCTURES
Authors: Buentsov I. O
Published: September 2022

One of the main problems in fixing non-removable orthopedic structures (crowns and bridges) is a violation of the odontopreparation technique. For a strong and reliable fixation of non-removable orthopedic structures, special requirements must be imposed on them in terms of the shape and surface of the support of the processed tooth. These requirements include: parallelism of the walls of the prepared tooth (must be cylindrical); parallelism of the vertical walls of several prepared teeth included in the bridge; smooth continuous gingival ledge [1, 2]. The parallel vertical walls of the prepared teeth provide the most reliable fixation of the prosthetic structure. The parallel walls of adjacent teeth ensure a secure anchoring of bridges. A smooth continuous gingival ridge of the correct shape ensures the tightness of the crown and excludes the penetration of infection between the crown and the tooth. When these three conditions are met in practice, you can be sure that this orthopedic design has the same route of introduction. Based on the analysis of literature data, it should be concluded that the development of odontopreparation methods in order to form the optimal supragingival part of the tooth for further prosthetics is an urgent problem. The development and clinical implementation of dental navigation technologies contribute to the development of methods for monitoring odontopreparations in orthopedic dentistry. The purpose of this article was to analyze the existing methods of odontopreparation and identify the most effective ones among them.
GENETIC MARKERS OF TRANSFORMATION OF BORDERLINE OVARIAN TUMORS INTO HIGHLY DIFFERENTIATED OVARIAN CANCER
Authors: Gozman E. S
Published: September 2022

Ovarian neoplasms are in the leading positions in the structure of oncological diseases of the reproductive system of women. Moreover, malignant ovarian tumors, as a rule, are detected only in the late stages of the disease, so ovarian cancer is the main cause of unfavorable and fatal outcomes in gynecological oncology. Accordingly, clinical criteria and instrumental studies are not enough to distinguish the forms of tumors from each other, to assess the possibility of transformation of a borderline tumor into a malignant one, as well as to determine the stage of development of the tumor process, therefore, genetic markers of transformation of borderline ovarian tumors into highly differentiated ovarian cancer are used and studied for diagnostic purposes. This paper provides information on genetic markers of the transformation of borderline ovarian tumors into highly differentiated ovarian cancer. Based on the analysis of literature data, it was analyzed that mutational changes in genes such as BRAF, KRAS, PTEN, p53 affect the level of aggressiveness of tumor cells. A comprehensive study of genetic markers in clinical practice allows for early diagnosis of neoplasms, differential diagnosis of tumors, as well as increasing the efficiency of diagnosis and treatment of ovarian neoplasms.
PHILOSOPHICAL ASPECTS IN THE WORKS OF S.N. KASATKIN AND HIS SCHOOL
Authors: Krayushkin A. I , Komissarova E. V , Korobkeev A. A , Kalashnikova S. A
Published: September 2022

In this lecture, the main points of the work and the principles formulated by Sergey Nikolaevich Kasatkin will be considered. S.N. Kasatkin was one of the first, along with P.F. Lesgaft, V.V. Kupriyanov, M.R. Sapin and others, who stood at the origins of the creation of the methodology of human anatomy.
EPIDEMIC MANIFESTATIONS OF COVID-19 IN THE VOLGOGRAD REGIONDURING THE 2020-2021 PERIOD
Authors: Udovichenko S. K , Nikitin D. N , Zhukov K. V , Toporkov A. V , Viktorov D. V , Zubareva O. V , Klimina I. A , Taratutina M. N
Published: September 2022

Study objective. The researching of COVID-19 epidemic process features in the Volgograd region during 2020-2021. Materials and methods. The analvsis based on statistical data from the Office of Rospotrebnadzor in the Volgograd Region on the incidence of COVID-19 was carried out. The main research method is epidemiological analysis. Results and discussion. For the period from March 24, 2020 to September 6, 2021, 83 814 cases of SARS-Cov-2 infection were registered in the Volgograd Region, the incidence rate was 3 344.76 per 100 000 population (95 % CI: 3 321,97-3 367,55), case fatality rate - 2,77 %. In the development dynamics of COVID-19 epidemic process in the Volgograd region, three seasonal incidence increases are identified: April - June 2020 (relatively low), September 2020 - February 2021 (high), June 2021 - present (the highest). It is shown that the third rise in the incidence rate is caused by the combined effect of a number of factors - the intensification of seasonal migration, the spread of a new genetic variant of the pathogen ("delta" genovariant, B.1.617.2) and low vaccination coverage of the population. An excess of the regional average incidence rate (3 344,76) was established in 13 districts of the region, the most affected territories are Volgograd (40,3 % of the total number of cases), Volzhsky (15,7 %) and Kamyshinsky district (6,1 %). The distribution of cases by sex revealed the predominance of women (60,3 %) in all age groups, with the exception of 0-18 years old and 70 years and older. The greatest contribution to the incidence of COVID-19 over the entire observation period is made by the age groups 50-59 years (17,7 %) and 60-69 years (17,4 %). During the third wave of incidence, active involvement of the 0-18 age group in the epidemic process and a decrease in the proportion of people 60 and older were established. The clinical picture of the disease is characterized by the prevalence of the mild course of the disease (64,4 %), there is a tendency for the reduction of moderate and asymptomatic forms.