bluuebunny/crossref_metadata_2025 huggingface dataset:
Predicting the Potential Distribution of the Szechwan Rat Snake (Euprepiophis perlacea) and Its Response to Climate Change in the Yingjing Area of the Giant Panda National Park
Authors: Song Xinqiang , Jiang Ying , Zhao Li , Jin Long , Yan Chengzhi , Liao Wenbo
Published: December 2023

Climate change is a significant driver of changes in the distribution patterns of species and poses a threat to biodiversity, potentially resulting in species extinctions. Investigating the potential distribution of rare and endangered species is crucial for understanding their responses to climate change and for the conservation of biodiversity and ecosystem management. The Szechwan rat snake (Euprepiophis perlacea) is an endemic and endangered species co-distributed with giant pandas, and studying its potential distribution contributes to a better understanding of the distribution pattern of endangered species. In this study, we confirmed seven presence points of this species in the Yingjing Area of the Giant Panda National Park, and selected eleven key factors to predict the potential distribution of E. perlacea under current and future scenarios using MaxEnt models. Our study consistently achieved AUC values exceeding 0.79, meeting the precision requirements of the models. The results indicated that the high potential distribution area of E. perlacea is mainly located near Yunwu mountain and the giant panda rewilding and reintroduction base, accounting for approximately 12% of the protected area. Moreover, we identified the primary environmental factors influencing the distribution of E. perlacea as the distance from streams and the slope degree, with their contribution rates exceeding 41% and 31%, respectively. In comparison to the current scenario, the potential habitat range for E. perlacea did not show an overall reduction in the context of future climate scenarios. To ensure the long-term preservation of E. perlacea, it is advisable to validate its actual distribution based on the models’ results. Particular attention should be given to safeguarding its core distribution areas and raising awareness among residents within the potential distribution range about the conservation of E. perlacea.
Mitigating Nitrate Concentration Using an Optimal Cropping Pattern Developed by Linking a Soil and Water Assessment Tool with Evolutionary Optimization
Authors: Sedighkia Mahdi , Datta Bithin
Published: December 2023

The unplanned development of agricultural land and urban areas poses threats to water quality, which can lead to the death of the aquatic species in rivers. The present study developed a novel framework by combining a soil and water assessment tool (SWAT) and evolutionary algorithms to optimize the cultivation pattern at the catchment scale in the Tajan River basin, with the aim of mitigating the environmental impacts of surface runoff from farms. This river basin is located in northern Iran, where quick agricultural development is one of the environmental challenges. We utilized a SWAT to simulate the nitrate concentrations for different crops at the river basin scale by applying the Nash–Sutcliffe model efficiency coefficient (NSE) as a measurement index. Then, a novel model was developed to optimize the cultivation pattern by applying different metaheuristic algorithms. Fuzzy technique for order of preference by similarity to ideal solution (TOPSIS) was applied as a decision-making system to select the best optimization algorithm. The results demonstrated that using a SWAT in the optimization model structure is a robust method for the design of an optimal cultivation pattern. The Nash–Sutcliffe model efficiency coefficient (NSE) was 0.74, demonstrating the robust predictive skills of the water quality model. The decision-making system indicated that particle swarm optimization and shuffled complex evolution were the best evolutionary algorithms to optimize the cultivation pattern using the proposed method. The proposed method opens a new window regarding the optimization of cultivation patterns in agriculture and provides an environmental-based optimization to design cultivation patterns on the catchment scale.
A Study on the Elastoplastic Stable Bearing Capacity of Double-Steering Prestressed Plate Columns
Authors: Li Yanying , Li Bailong , Yin Xinsheng , Han Zhiying , Li Zhipeng
Published: December 2023

This study investigates the elastoplastic stable bearing capacity of prestressed columns. The end restraint of the novel dual-steering plate brace prestressed column is enhanced, augmenting the efficiency of utilizing steel material. The elastoplastic stable bearing capacity of this new prestressed column is 5.41 times greater than that of a standard non-prestressed column. In contrast, the traditional prestressed columns with identical parameters show only a 2.49 to 3.55 times increase. In addition, this study conducts parameter optimization on the prestressed value, the position of the transverse brace, and the size of the transverse brace in the prestressed column. The buckling load escalates rapidly with an increase in the prestress value within a specific range and then diminishes gradually. The bearing capacity peaks when the transverse brace is positioned at the midpoint. As the size of the transverse brace expands, the load-bearing capacity initially rises linearly and subsequently stabilizes. The findings on the elastoplastic stable bearing capacity and parameter optimization are significantly relevant for practical engineering applications.
The Current Treatment Landscape of Malignant Pleural Mesothelioma and Future Directions
Authors: Bertin Beatriz , Zugman Miguel , Schvartsman Gustavo
Published: December 2023

The incidence of malignant pleural mesothelioma is expected to increase globally. New treatment options for this malignancy are eagerly awaited to improve the survival and quality of life of patients. The present article highlights the results of recent advances in this field, analyzing data from several relevant trials. The heterogeneous tumor microenvironment and biology, together with the low mutational burden, pose a challenge for treating such tumors. So far, no single biomarker has been soundly correlated with targeted therapy development; thus, combination strategies are often required to improve outcomes. Locally applied vaccines, the expansion of genetically engineered immune cell populations such as T cells, the blockage of immune checkpoints that inhibit anti-tumorigenic responses and chemoimmunotherapy are among the most promising options expected to change the mesothelioma treatment landscape.
SBRT of Spinal Metastases Using a Simultaneous Integrated Boost Concept in Oligometastatic Cancer Patients Is Safe and Effective
Authors: Waltenberger Maria , Strick Christian , Vogel Marco M. E. , Diehl Christian , Combs Stephanie E.
Published: December 2023

(1) Purpose: To assess the safety and effectivity of stereotactic body radiotherapy (SBRT) on spinal metastases utilizing a simultaneous integrated boost (SIB) concept in oligometastatic cancer patients. (2) Methods: 62 consecutive patients with 71 spinal metastases received SIB–SBRT between 01/2013 and 09/2022 at our institution. We retrospectively analyzed toxicity, local tumor control (LC), and progression-free (PFS) and overall survival (OS) following SIB–SBRT and assessed possible influencing factors (Kaplan–Meier estimator, log-rank test and Cox proportional-hazards model). (3) Results: SIB–SBRT was delivered in five fractions, mostly with 25/40 Gy (n = 43; 60.56%) and 25/35 Gy (n = 19, 26.76%). Estimated rates of freedom from VCF were 96.1/90.4% at one/two years. VCF development was significantly associated with osteoporosis (p < 0.001). No ≥ grade III acute and one grade III late toxicity (VCF) were observed. Estimated LC rates at one/two years were 98.6/96.4%, and histology was significantly associated with local treatment failure (p = 0.039). Median PFS/OS was 10 months (95% CI 6.01–13.99)/not reached. Development of metastases ≥ one year after initial diagnosis and Karnofsky Performance Score ≥ 90% were predictors for superior PFS (p = 0.038) and OS (p = 0.012), respectively. (4) Conclusion: Spinal SIB–SBRT yields low toxicity and excellent LC. It may be utilized in selected oligometastatic patients to improve prognosis. To the best of our knowledge, we provide the first clinical data on the toxicity and effectivity of SIB–SBRT in spinal metastases in a larger patient cohort.
Effect of NaF Doping on the Microstructure and Thermoelectric Performance of BiCuSeO Ceramics
Authors: Pei Zhenbing , Xiang Guangqi , Sun Xin , Fu Zhuang , Qiao Yanxin , Wang Lei , Dong Songtao , Chen Jian
Published: December 2023

The layered oxyselenide BiCuSeO has attracted significant attention due to its ability to demonstrate low thermal conductivity and a high Seebeck coefficient. This research project involved the synthesis of Bi1−xNaxCuSeO1−xFx (x = 0, 0.05, 0.10, 0.15, and 0.20) ceramics using high-energy ball milling and cold isostatic pressing techniques. A comprehensive investigation was conducted to examine the influence of co−doping NaF on the thermoelectric properties of BiCuSeO ceramics. The substitution of Bi3+ with Na+ introduces a substantial number of holes, resulting in a remarkable improvement in the electrical conductivity and power factor. The conductivity was significantly increased from 9.10 S cm−1 (BiCuSeO) to 94.5 S cm−1 (Bi0.85Na0.15CuSeO0.85F0.15) at 323 K. Additionally, at 823 K, the power factor of the Bi0.85Na0.15CuSeO0.85F0.15 sample reached 44.8 × 10−5 W/m K2. Furthermore, the Bi1−xNaxCuSeO1−xFx ceramics demonstrated a minimum thermal conductivity of 0.43 W m−1 K−1. Consequently, the Bi0.85Na0.15CuSeO0.85F0.15 sample achieved a maximum ZT value of 0.78, which is 7.09 times higher than that of the pure BiCuSeO sample (0.11).
Nickel Coatings on Ceramic Materials Using Different Diffusion Techniques
Authors: Sharma Mala M. , Stutzman Amanda M. , Schreiber Jeremy M. , Wolfe Douglas E. , Eden Timothy J.
Published: December 2023

Diffusion bonding is a process that has proven effective for the joining of metal to ceramic, but the differences in coefficient of thermal expansion still pose challenges during and after the bonding process. This work details the exploration of traditional diffusion-bonding processes using two traditional approaches, which include bonding of a 99.9+% pure Ni foil to SiC, Si3N4, and YSZ disks using (1) a hot isostatic press (HIP), with and without added weight to promote interfacial contact, and (2) field-assisted sintering (FAST). Samples were consolidated by heating to 1200 °C and held for 6 h under vacuum before cooling to room temperature during the HIP method. For the FAST technique, bonding experiments were performed at both 800 °C and 1200 °C in a vacuum environment under 10 MPa uniaxial pressure. After the Ni was bonded to the ceramics, diffusion heat treatments were carried out in the HIP. For electroless-plated samples, the heat-treatment temperature was chosen as 825 °C to avoid melting. For electroplated samples, heat treatment occurred at 925 °C or higher. Electroplated YSZ samples were heat-treated at 1150 °C as the Ni-Si eutectic is not a concern in this system. The time at temperature varied from 6 h to 48 h depending on the material combination tested. Post-heat-treatment diffusion characteristics were analyzed using scanning electron microscopy (SEM) with energy-dispersive X-ray spectroscopy (EDS). A main cause of poor bonding performance in the HIP samples was reduced interfacial contact, while cohesive failures in the FAST samples are likely due to the formation of brittle intermetallic Ni-Si phases. Preliminary results indicate success in bonding Ni to SiC, Si3N4, and YSZ using a diffusion-enhanced approach on electroplated specimens.
Lead-Free Organic Manganese (II) Bromide Hybrid with Highly Efficient and Stable Green Emission for UV Photodetection
Authors: Tian Ye , Wei Qilin , Duan Lian , Peng Chengyu
Published: December 2023

Lead halide perovskites have been widely used in optoelectronic devices due to their excellent properties; however, the toxicity of lead and the poor stability of these perovskites hinder their further application. Herein, we report a zero-dimensional (0D) lead-free organic manganese (II) bromide hybrid compound of (TBA)2MnBr4 (TBA+ = tetrabutylammonium cation) single crystals (SCs) with great environmental stability. The (TBA)2MnBr4 SCs show a strong green emission peak at 518 nm with a high photoluminescence quantum yield (PLQY) of 84.98% at room temperature, which is attributed to the d-d transition of single Mn2+ ions, as also confirmed through density functional calculation. A green light-emitting diode was produced based on (TBA)2MnBr4 SCs, which exhibited CIE coordinates (0.17, 0.69) close to those of standard green. A photodetector fabricated by the (TBA)2MnBr4 SCs shows an obvious photo response with a rapid millisecond rise/decay response time (at 365 nm). Our findings promote the research of Mn(II)-based organic–inorganic hybrid materials and pave the way by using these materials for future high-performance optoelectronic devices.
Preliminary Investigation into the Prevalence of G6PD Deficiency in a Pediatric African American Population Using a Near-Patient Diagnostic Platform
Authors: Leung-Pineda Van , Weinzierl Elizabeth P. , Rogers Beverly B.
Published: December 2023

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is prevalent in the African American population. We identified eighteen G6PD-deficient samples (9%) in a study of residual, de-identified whole blood specimens from 200 African American pediatric patients using a point-of-care instrument. This highlights the possibility of a rapid time to result for G6PD testing, which can be valuable in some clinical scenarios.
Prophylactic Medication during Radioembolization in Metastatic Liver Disease: Is It Really Necessary? A Retrospective Cohort Study and Systematic Review of the Literature
Authors: Braat Manon N. G. J. A. , Ebbers Sander C. , Alsultan Ahmed A. , Neek Atal O. , Bruijnen Rutger C. G. , Smits Maarten L. J. , de Bruijne Joep , Lam Marnix G. E. H. , Braat Arthur J. A. T.
Published: December 2023

Purpose: Trans-arterial radioembolization is a well-studied tumoricidal treatment for liver malignancies; however, consensus and evidence regarding periprocedural prophylactic medication (PPM) are lacking. Methods: A single-center retrospective analysis from 2014 to 2020 was performed in patients treated with 90Y-glass microspheres for neuroendocrine or colorectal liver metastases. Inclusion criteria were the availability of at least 3 months of clinical, biochemical, and imaging follow-up and post-treatment 90Y-PET/CT imaging for the determination of the whole non-tumorous liver absorbed dose (Dh). Logistic regression models were used to investigate if variables (among which are P/UDCA and Dh) were associated with either clinical toxicity, biochemical toxicity, or hepatotoxicity. Additionally, a structured literature search was performed in November 2022 to identify all publications related to PPM use in radioembolization treatments. Results: Fifty-one patients received P/UDCA as post-treatment medication, while 19 did not. No correlation was found between toxicity and P/UDCA use. Dh was associated with biochemical toxicity (p = 0.05). A literature review resulted in eight relevant articles, including a total of 534 patients, in which no consistent advice regarding PPM was provided. Conclusion: In this single-center, retrospective review, P/UDCA use did not reduce liver toxicity in patients with metastatic liver disease. The whole non-tumorous liver-absorbed dose was the only significant factor for hepatotoxicity. No standardized international guidelines or supporting evidence exist for PPM in radioembolization.
Relevant Aspects in the Development of Electrochemical Aptasensors for the Determination of Antibiotics—A Review
Authors: da Silva Daniela Nunes , Pereira Arnaldo César
Published: December 2023

Aptamers are three-dimensional structures of DNA or RNA that present high affinity and selectivity to specific targets, obtained through in vitro screening. Aptamers are used as biological recognizers in electrochemical biosensors, the so-called aptasensors, providing greater specificity in recognizing the most diverse analytes. Electrochemical aptasensors have extremely relevant characteristics, such as high sensitivity, low cost compared to other biorecognizers such as antibodies, and excellent compatibility, being considered one of the most promising alternative methods in several areas, such as biomedical diagnosis and monitoring environmental contaminants. In this sense, the present work reviews the relevant aspects of methodologies based on electrochemical aptasensors and their applications in determining antibiotics, seeking to foster innovation in electrochemical biosensors.
Measurement and Influencing Factors of Willingness to Accept Payment for Ecosystem Service Provision: A Case Study of a Leading Forest Farm in China
Authors: Guo Tongfang , Wu Shuirong , Zhang Xufeng , Zhang Chao , Yang Jinrong , Cheng Shun
Published: December 2023

The Saihanba Forest Farm, a leading planted forest farm, is one of the essential ecosystem service providers for the Beijing–Tianjin–Hebei region in China. Its efforts in afforestation and landscape restoration have been recognized with the award of the Champions of the Earth from the United Nations. However, the Saihanba Forest Farm is facing the challenges of less income resulting from less commercial cutting since it has to prioritize providing ecosystem services such as water conservation, wind prevention, sand fixation, and so on, instead of timber. It is crucial to understand providers’ attitudes toward ecosystem service provision and willingness to accept payment, as it might affect the quantity and quality of ecosystem service provision in the future. In this study, the contingent valuation method was applied to measure the willingness to accept payment for the economic losses incurred due to providing ecosystem services by cutting less wood. A questionnaire survey was conducted among the staff of the Saihanba Forest Farm. A double-hurdle regression model was used to analyze the influencing factors of the willingness to accept payment, with the validation via a Tobit model. The results showed that the Saihanba Forest Farm was willing to accept a payment of CNY 9800.84 (USD 1407.24) per hectare per year for providing ecosystem services to enhance social welfare. The factors, including basic sociodemographic characteristics, attitudes toward conservation activities, and awareness on the concept of payment for ecosystem services, significantly influenced their willingness to accept payment.
The Influence of GVC Participation and Division of Labor Status on the Comparative Advantage of China’s Wood-Based Panel Industry
Authors: Luo Yiyi , Zhao Wenqi , Cheng Baodong , Tao Chenlu
Published: December 2023

This article innovatively proposes a new display comparative advantage index (NB*). Based on the characteristics of existing comparative advantage indices and practical research needs, the NB* index can more accurately measure whether a country’s products have comparative advantages among other countries within the selected region, which to some extent expands the research boundary of industrial international competitiveness evaluation indicators. Meanwhile, this article takes China’s wood-based panel industry as an example to calculate the comparative advantage level of China’s wood-based panel industry among Regional Comprehensive Economic Partnership (RCEP) member countries and further explores the impact of global value chain participation and division of labor status on the international competitiveness of the industry. Research has found that, firstly, although China’s wood-based panel industry has a relatively lower level of comparative advantage among RCEP member countries, it still has a certain level of competitiveness in some developed and developing countries’ markets; Secondly, in terms of the wood-based panel industry, a higher level of global value chain participation can effectively improve the international comparative advantage level of the domestic wood-based panel industry. Thirdly, the level of division of labor in the industrial chain has a significant positive impact on the comparative advantage level of China’s wood-based panel industry in RCEP member countries. Therefore, in order to enhance the international competitiveness of the domestic wood-based panel industry, it is necessary to actively participate in the global value chain and continuously move towards a higher level of division of labor in the industry chain.
Study on Reciprocating Loading Tests and Moment-Rotation Theory of Straight-Tenon Joints in Traditional Wooden Structures
Authors: Yu Shibin , Pan Wen , Su Hexian , Ye Liaoyuan
Published: December 2023

For the study of the mechanical properties of straight-tenon joints in traditional wooden structures, three specimens of T-shaped straight-tenon joints were made according to actual structures and subjected to reciprocating loading tests. The variation rules of different seismic performance indexes such as moment-rotation hysteresis curve, skeleton curve, stiffness, and energy dissipation capacity of the specimens were analyzed through tests. Based on the geometric deformation and static equilibrium conditions, the moment-rotation theoretical model of straight-tenon joints is derived and compared with the experimental results. The studies show that the hysteresis curve of joints under reciprocating loading consists of four stages: ascending, stress relaxation, descending, and sliding. The moment capacity of joints increases gradually with the rotational deformation, but the internal gap of the joints increases synchronously, resulting in a serious attenuation of the stiffness. Tenon and mortise plastic extrusion deformation and friction can dissipate energy, as the rotational deformation increases energy consumption, while the hysteresis loop “pinch” effect is more serious, and the equivalent viscous damping coefficient is gradually reduced. The prediction results of the joint moment-rotation theoretical model are closer to the experimental results, which can provide a theoretical basis for the overall seismic analysis of traditional wooden structures.
Probabilistic Models and Deep Learning Models Assessed to Estimate Design and Operational Ocean Wave Statistics to Reduce Coastal Hazards
Authors: Sinha Mourani , Bhattacharya Mrinmoyee , Seemanth M. , Bhowmick Suchandra A.
Published: December 2023

Probabilistic models for long-term estimations and deep learning models for short-term predictions have been evaluated and analyzed for ocean wave parameters. Estimation of design and operational wave parameters for long-term return periods is essential for various coastal and ocean engineering applications. Three probability distributions, namely generalized extreme value distribution (EV), generalized Pareto distribution (PD), and Weibull distribution (WD), have been considered in this work. The design wave parameter considered is the maximal wave height for a specified return period, and the operational wave parameters are the mean maximal wave height and the highest occurring maximal wave height. For precise location-based estimation, wave heights are considered from a nested wave model, which has been configured to have a 10 km spatial resolution. As per availability, buoy-observed data are utilized for validation purposes at the Agatti, Digha, Gopalpur, and Ratnagiri stations along the Indian coasts. At the stations mentioned above, the long short-term memory (LSTM)-based deep learning model is applied to provide short-term predictions with higher accuracy. The probabilistic approach for long-term estimation and the deep learning model for short-term prediction can be used in combination to forecast wave statistics along the coasts, reducing hazards.
Design of a Low-Power Delay-Locked Loop-Based 8× Frequency Multiplier in 22 nm FDSOI
Authors: Naveed  , Dix Jeff
Published: December 2023

A low-power delay-locked loop (DLL)-based frequency multiplier is presented. The multiplier is designed in 22 nm FDSOI and achieves 8× multiplication. The proposed DLL uses a new simple duty cycle correction circuit and is XOR logic-based for frequency multiplication. Current starved delay cells are used to make the circuit power efficient. The circuit uses three 2× stages instead of an edge combiner to achieve 8× multiplication, thus requiring far less power and chip area as compared to conventional phase-locked loop (PLL) circuits. The proposed 8× multiplier occupies an active area of 0.09 mm2. The measurement result shows ultra-low power consumption of 130 µW at 0.8 V supply. The post-layout simulation shows a timing jitter of 24 ps (pk-pk) at 2.44 GHz.
Time to Deliver on Promises: The Role of ERBB2 Alterations as Treatment Options for Colorectal Cancer Patients in the Era of Precision Oncology
Authors: Buchholz Soeren M. , Nause Nelia , König Ute , Reinecke Johanna , Steuber Benjamin , Ammer-Herrmenau Christoph , Reuter-Jessen Kirsten , Bohnenberger Hanibal , Biggemann Lorenz , Braulke Friederike , Neesse Albrecht , Ellenrieder Volker , Ströbel Philipp , Adler Marius , König Alexander
Published: December 2023

Receptor tyrosine kinase erythroblastic oncogene B2 (ERBB2), also known as human epidermal growth factor receptor 2 (HER2), represents an oncogenic driver and has been effectively targeted in breast and gastric cancer. Recently, next-generation sequencing (NGS) discovered ERBB2 as a promising therapeutic target in metastatic colorectal cancer (mCRC), where it is altered in 3–5% of patients, but no therapies are currently approved for this use. Herein, we present the experience of a single center in diagnosing actionable genetic ERBB2 alterations using NGS and utilizing the latest therapeutic options. Between October 2019 and December 2022, a total of 107 patients with advanced CRC underwent molecular analysis, revealing actionable ERBB2 mutations in two patients and ERBB2 amplifications in two other patients. These findings correlated with immunohistochemical (IHC) staining. Of these four patients, two were treated with trastuzumab-deruxtecan (T-DXd). We present two exemplary cases of patients with actionable ERBB2 alterations to demonstrate the effectiveness of T-DXd in heavily pretreated ERBB2-positive mCRC patients and the need for early molecular profiling. To fully exploit the potential of this promising treatment, earlier molecular profiling and the initiation of targeted therapies are essential.
Guided Genioplasty: Comparison between Conventional Technique and Customized Guided Surgery
Authors: Antúnez-Conde Hidalgo Raúl , Silva Canal José Luis , Navarro Cuéllar Carlos , Sánchez Gallego-Albertos Celia , Arias Gallo Javier , Navarro Cuéllar Ignacio , López Davis Antonio , Demaria Martínez Gastón , Naranjo Aspas Néstor , Zamorano León José , Chamorro Pons Manuel
Published: December 2023

Background: Genioplasty as an isolated surgical technique is a highly demanded procedure in the maxillofacial surgery area. Advances in facial reconstructive surgery have been associated with less morbidity and more predictable results. In this paper, “conventional” genioplasty and genioplasty by means of virtual surgical planning (VSP), CAD-CAM cutting guides, and patient custom-made plates are compared. Methods: A descriptive observational study was designed and implemented, and 43 patients were treated, differentiating two groups according to the technique: 18 patients were treated by conventional surgery, and 25 patients were treated through virtual surgical planning (VSP), CAD-CAM cutting guides, STL models, and titanium patient-specific plates. Results: The operation time ranged from 35 to 107 min. The mean operative time in the conventional group was 60.06 + 3.74 min.; in the custom treatment group it was 42.24 + 1.29 min (p < 0.001). The difference between planned and obtained chin changes in cases of advancement or retrusion was not statistically significant (p = 0.125; p = 0.216). In cases of chin rotation due to asymmetry, guided and personalized surgery was superior to conventional surgery (p < 0.01). The mean hospital stay was equal in both groups. A decrease in surgical complications was observed in the group undergoing VSP and customized treatment. Conclusions: Multi-stage implementation of VSP with CAD-CAM cutting guides, STL models, and patient-specific plates increased the accuracy of the genioplasty surgery, particularly in cases of chin asymmetry, reducing operation time and potential complications.
Comparative Study of Post-Surgical Outcomes in Pain, Disability, and Health-Related Quality of Life for Adult Spinal Deformity in Patients Aged above and below 75 Years
Authors: Park Yeonsu , Kim Jiyoon , Kim Ho-Joong , Oh Seungtak , Park Joon-Hee , Shim Daechul , Park Jin-Ho
Published: December 2023

(1) Background: Adult spinal deformity (ASD) surgery is known to improve clinical and radiological parameters; however, it may also cause more complications in elderly patients. The purpose of this study was to compare the outcomes of ASD surgery, specifically regarding pain, disability, and health-related quality of life (HRQOL) in patients aged 75 years and over and patients aged under 75 years; (2) Methods: A total of 151 patients who underwent ASD surgery between August 2014 and September 2020 were included. Patients were divided into two groups based on whether they are 75 years and over or under. Radiological parameters measured included sagittal vertical axis (SVA), pelvic tilt (PT), and pelvic incidence (PI)- lumbar lordosis (LL). Data were collected 3, 6, and 12 months after surgery; (3) Results: At 12 months postoperatively, visual analog scale (VAS) for low back pain (p = 0.342), Oswestry disability index (ODI) (p = 0.087), and EuroQol 5-Dimensions (EQ-5D) (p = 0.125) did not differ between patients under 75 years and those 75 and above 75 group. PT (p = 0.675), PI-LL (p = 0.948), and SVA (p = 0.108) did not differ significantly 12 months after surgery in the two groups. In the entire patient group, compared to preoperative data, significant improvements were demonstrated for clinical and radiological parameters 12 months after surgery (all p < 0.001). The rate of medical complications did not correlate with age, but the rates of proximal junctional kyphosis (PJK) and proximal junctional failure (PJF) did (p = 0.638, p < 0.001, and p = 0.001, respectively); (4) Conclusions: In terms of clinical and radiological improvements, ASD surgery should be considered for patients regardless of whether they are younger than or older than 75 years. The clinical and radiological improvements and the risk of complications and revision surgeries must be considered in ASD patients who are 75 years or older.
Preparation and Characterization of Polyethersulfone/Activated Carbon Composite Membranes for Water Filtration
Authors: Prihandana Gunawan Setia , Maulana Sayed Sulthan , Soedirdjo Rahmat Santoso , Tanujaya Venni , Pramesti Desak Made Adya , Sriani Tutik , Jamaludin Mohd Fadzil , Yusof Farazila , Mahardika Muslim
Published: December 2023

Ultrafiltration membrane technology holds promise for wastewater treatment, but its widespread application is hindered by fouling and flux reduction issues. One effective strategy for enhancing ultrafiltration membranes involves incorporating activated carbon powder. In this study, composite polyethersulfone (PES) ultrafiltration membranes were fabricated to include activated carbon powder concentrations between 0 and 1.5 wt.%, with carbon size fixed at 200 mesh. The ultrafiltration membranes were evaluated in terms of membrane morphology, hydrophilicity, pure water flux, equilibrium water content, porosity, average pore size, protein separation, and E-coli bacteria removal. It was found that the addition of activated carbon to PES membranes resulted in improvements in some key properties. By incorporating activated carbon powder, the hydrophilicity of PES membranes was enhanced, lowering the contact angle from 60° to 47.3° for composite membranes (1.0 wt.% of activated carbon) compared to the pristine PES membrane. Water flux tests showed that the 1.0 wt.% composite membrane yielded the highest flux, with an improvement of nearly double the initial value at 2 bar, without compromising bovine serum albumin rejection or bacterial removal capabilities. This study also found that the inclusion of activated carbon had a minor impact on the membrane’s porosity and equilibrium water content. Overall, these insights will be beneficial in determining the optimal concentration of activated carbon powder for PES ultrafiltration membranes.
Evolution of the Heterogeneous Microstructure of a 12Cr1MoV Welded Joint after Post-Weld Heat Treatment and Its Effect on Mechanical Properties
Authors: Yang Bin , Sun Guanghua , Hu Xiaodong , Liu Zichen , Xie Xuefang , Peng Wei , Shao Xiaoming
Published: December 2023

The non-uniformity of microstructures and mechanical properties across a whole welded joint is a crucial factor leading to its weakening performance and premature failure. Post-weld heat treatment is a primary method for increasing the mechanical properties. However, the evolution mechanism of mechanical properties related to heterogeneous microstructure after heat treatment remains unclear, making it challenging to design the heat treatment process and evaluate its effect comprehensively. In this study, microstructure characterization and a series of mechanical tests of 12Cr1MoV welded joint after the stress relief annealing (SRA) and tempering heat treatment (THT) were conducted. The effect of heat treatment on mechanical properties is analyzed based on the comparison between stress relief annealing and tempering heat treatment in terms of tensile properties, impact toughness, and impact fracture morphology. The results indicate that, after the tempering heat treatment, the evolution of mechanical properties in each subzone of the joint is consistent, i.e., the hardness and tensile strength decreased while the toughness increased. Notably, the most substantial enhancement in toughness is observed in the weld zone, primarily due to a significant reduction in the presence of pre-eutectoid ferrite. Furthermore, it is proved that hardness is an indicator to reflect changes in tensile strength related to the microstructure evolution, which indicates it can be employed to evaluate the effectiveness of post-weld heat treatment in practical engineering.
Metabolic Alterations in NADSYN1-Deficient Cells
Authors: Meijer Nils W. F. , Gerrits Johan , Zwakenberg Susan , Zwartkruis Fried J. T. , Verhoeven-Duif Nanda M. , Jans Judith J. M.
Published: December 2023

NAD synthetase 1 (encoded by the gene NADSYN1) is a cytosolic enzyme that catalyzes the final step in the biosynthesis of nicotinamide adenine dinucleotide (NAD+) from tryptophan and nicotinic acid. NADSYN1 deficiency has recently been added to the spectrum of congenital NAD+ deficiency disorders. To gain insight into the metabolic consequences of NADSYN1 deficiency, the encoding gene was disrupted in A549 and HEK293T cells, and the metabolome was profiled in the presence of different NAD+ precursors, including tryptophan, nicotinamide and nicotinic acid. We demonstrate that when precursors of the NAD+ salvage pathway in the form of nicotinamide become limiting, NADSYN1 deficiency results in a decline in intracellular NAD+ levels even in the presence of other potential NAD+ sources such as tryptophan and nicotinic acid. As a consequence, alterations in 122 and 69 metabolites are observed in NADSYN1-deficient A549 and HEK293T cells compared to the wild-type cell line (FC > 2 and p < 0.05). We thus show that NADSYN1 deficiency results in a metabolic phenotype characterized by alterations in glycolysis, the TCA cycle, the pentose phosphate pathway, and the polyol pathway.
Towards High Efficiency and Rapid Production of Room-Temperature Liquid Metal Wires Compatible with Electronic Prototyping Connectors
Authors: Morita Luka , Jalali Shima , Vaheb Abolfazl , Elsersawy Rawan , Golwala Kunj , Asad Asad , Dolez Patricia I. , Hogan James D. , Khondoker Mohammad Abu Hasan , Sameoto Dan
Published: December 2023

We present in this work new methodologies to produce, refine, and interconnect room-temperature liquid-metal-core thermoplastic elastomer wires that have extreme extendibility (>500%), low production time and cost at scale, and may be integrated into commonly used electrical prototyping connectors like a Japan Solderless Terminal (JST) or Dupont connectors. Rather than focus on the development of a specific device, the aim of this work is to demonstrate strategies and processes necessary to achieve scalable production of liquid-metal-enabled electronics and address several key challenges that have been present in liquid metal systems, including leak-free operation, minimal gallium corrosion of other electrode materials, low liquid metal consumption, and high production rates. The ultimate goal is to create liquid-metal-enabled rapid prototyping technologies, similar to what can be achieved with Arduino projects, where modification and switching of components can be performed in seconds, which enables faster iterations of designs. Our process is focused primarily on fibre-based liquid metal wires contained within thermoplastic elastomers. These fibre form factors can easily be integrated with wearable sensors and actuators as they can be sewn or woven into fabrics, or cast within soft robotic components.
High Repetition Frequency Solid-State Green Laser with Large Stable Area for Water Jet Guided
Authors: Wang Ji , Zhang Wenwu
Published: December 2023

This paper presents the design and experimental results of a long cavity length Nd:YAG laser with a large stable zone for water jet-guided laser (WJGL) applications. The design is based on the light transmission matrix and resonator stability conditions, aiming to achieve a large stable zone and a short cut-off thermal focal length (CTFL). A folded concave resonator is researched to enhance the cavity length, and the influence of the tunable cavity arm length on the oscillating beam in the resonator and in the YAG crystal is theoretically studied. Moreover, the effects of the output mirror curvature and the cavity arm length on the range of the stable area and the cut-off thermal focal length are also investigated. Experimental results show that a stable green laser output is obtained after second harmonic generation (SHG) with a pulse width ranging from 43 to 143 ns within the laser operating frequency range of 5–20 kHz. At an operation frequency of 10 kHz, the output power is 21.33 W, and the instability of the output power within 400 min is 0.88%. The laser source achieves a maximum power of 25.7 W at 20 kHz, and the maximum single pulse energy reaches 2.7 mJ at 6 kHz. Finally, this is used as the laser source to couple with a water jet with a diameter of 100 microns, achieving a lossless water conductivity transmission over 60 mm length. These results demonstrate the suitability of the designed laser source for WJGL technology research. In precision machining applications, this technology exhibits processing advantages of low thermal damage (~2 μm) and large depth (>10 mm), for 7075 aluminum alloy.
Temperature-Enhanced Exciton Emission from GaAs Cone–Shell Quantum Dots
Authors: Heyn Christian , Ranasinghe Leonardo , Deneke Kristian , Alshaikh Ahmed , Blick Robert H.
Published: December 2023

The temperature-dependent intensities of the exciton (X) and biexciton (XX) peaks from single GaAs cone–shell quantum dots (QDs) are studied with micro photoluminescence (PL) at varied excitation power and QD size. The QDs are fabricated by filling self-assembled nanoholes, which are drilled in an AlGaAs barrier by local droplet etching (LDE) during molecular beam epitaxy (MBE). This method allows the fabrication of strain-free QDs with sizes precisely controlled by the amount of material deposited for hole filling. Starting from the base temperature T = 3.2 K of the cryostat, single-dot PL measurements demonstrate a strong enhancement of the exciton emission up to a factor of five with increasing T. Both the maximum exciton intensity and the temperature Tx,max of the maximum intensity depend on excitation power and dot size. At an elevated excitation power, Tx,max becomes larger than 30 K. This allows an operation using an inexpensive and compact Stirling cryocooler. Above Tx,max, the exciton intensity decreases strongly until it disappears. The experimental data are quantitatively reproduced by a model which considers the competing processes of exciton generation, annihilation, and recombination. Exciton generation in the QDs is achieved by the sum of direct excitation in the dot, plus additional bulk excitons diffusing from the barrier layers into the dot. The thermally driven bulk-exciton diffusion from the barriers causes the temperature enhancement of the exciton emission. Above Tx,max, the intensity decreases due to exciton annihilation processes. In comparison to the exciton, the biexciton intensity shows only very weak enhancement, which is attributed to more efficient annihilation processes.
Neuropsychology and Electroencephalography in Rural Children at Neurodevelopmental Risk: A Scoping Review
Authors: Galindo-Aldana Gilberto , Torres-González Cynthia
Published: December 2023

Children from rural areas face numerous possibilities of neurodevelopmental conditions that may compromise their well-being and optimal development. Neuropsychology and electroencephalography (EEG) have shown strong agreement in detecting correlations between these two variables and suggest an association with specific environmental and social risk factors. The present scoping review aims to describe studies reporting associations between EEG features and cognitive impairment in children from rural or vulnerable environments and describe the main risk factors influencing EEG abnormalities in these children. The method for this purpose was based on a string-based review from PubMed, EBSCOhost, and Web of Science, following the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA). Qualitative and quantitative analyses were conducted from the outcomes that complied with the selected criteria. In total, 2280 records were identified; however, only 26 were eligible: 15 for qualitative and 11 for quantitative analysis. The findings highlight the significant literature on EEG and its relationship with cognitive impairment from studies in children with epilepsy and malnutrition. In general, there is evidence for the advantages of implementing EEG diagnosis and research techniques in children living under risk conditions. Specific associations between particular EEG features and cognitive impairment are described in the reviewed literature in children. Further research is needed to better describe and integrate the state of the art regarding EEG feature extraction.
Single and Multitarget Systems for Drug Delivery and Detection: Up-to-Date Strategies for Brain Disorders
Authors: Grosso Clara , Silva Aurora , Delerue-Matos Cristina , Barroso Maria Fátima
Published: December 2023

This review summarizes the recent findings on the development of different types of single and multitarget nanoparticles for disease detection and drug delivery to the brain, focusing on promising active principles encapsulated and nanoparticle surface modification and functionalization. Functionalized nanoparticles have emerged as promising tools for the diagnosis and treatment of brain disorders, offering a novel approach to addressing complex neurological challenges. They can act as drug delivery vehicles, transporting one or multiple therapeutic agents across the blood–brain barrier and precisely releasing them at the site of action. In diagnostics, functionalized nanoparticles can serve as highly sensitive contrast agents for imaging techniques such as magnetic resonance imaging and computed tomography scans. By attaching targeting ligands to the nanoparticles, they can selectively accumulate in the affected areas of the brain, enhancing the accuracy of disease detection. This enables early diagnosis and monitoring of conditions like Alzheimer’s or Parkinson’s diseases. While the field is still evolving, functionalized nanoparticles represent a promising path for advancing our ability to diagnose and treat brain disorders with greater precision, reduced invasiveness, and improved therapeutic outcomes.
Correction: Yu et al. Rare-Earth-Metal (Nd3+, Ce3+ and Gd3+)-Doped CaF2: Nanoparticles for Multimodal Imaging in Biomedical Applications. Pharmaceutics 2022, 14, 2796
Authors: Yu Zhenfeng , He Yuanyuan , Schomann Timo , Wu Kefan , Hao Yang , Suidgeest Ernst , Zhang Hong , Eich Christina , Cruz Luis J.
Published: December 2023

In the original publication [...]
Silk Fibroin-Modified Liposome/Gene Editing System Knocks out the PLK1 Gene to Suppress the Growth of Lung Cancer Cells
Authors: Pan Peng , Liu Xueping , Fang Mengqi , Yang Shanlong , Zhang Yadong , Li Mingzhong , Liu Yu
Published: December 2023

Polo-like protein kinase 1 (PLK1) plays a key role in lung cancer cell mitosis. The knockout of PLK1 gene by the CRISPR–Cas9 system can effectively inhibit the proliferation of tumor cells, but there is no suitable vector for in vivo delivery. In this study, CRISPR–Cas9 gene knockout plasmids encoding sgRNA, Cas9 and green fluorescent protein were constructed. Then, the plasmids were packaged with liposome (Lip) and cholesterol-modified Antheraea pernyi silk fibroin (CASF) to obtain the CASF/Lip/pDNA ternary complex. The CASF/Lip/pDNA complex was transfected into lung cancer cells A549 to investigate the transfection efficiency, the PLK1 gene knockout effect and the inhibitory effect on lung cancer cells. The results showed that the transfection efficiency of the CASF/Lip/pDNA complex was significantly higher than that of the Lip/pDNA binary complex, and the expression of PLK1 in cells transfected with CASF/Lip/pDNA complexes was significantly lower than that in cells transfected with Lip/pDNA complexes. The CASF/Lip/pDNA complex significantly increased the apoptosis rate and decreased the proliferation activity of lung cancer cells compared with Lip/pDNA complexes. The cytotoxicity of the complexes was evaluated by coculture with the human bronchial epithelial cells BEAS2B. The results showed that CASF/Lip/pDNA complexes exhibited lower cytotoxicity than Lip/pDNA complexes. The fibroin-modified liposome/PLK1 gene knockout system not only effectively inhibited the growth of lung cancer cells but also showed no obvious toxicity to normal cells, showing potential for clinical application in lung cancer therapy.
The Pharmacokinetics of CPZEN-45, a Novel Anti-Tuberculosis Drug, in Guinea Pigs
Authors: Garcia-Contreras Lucila , Hanif Shumaila Nida Muhammad , Ibrahim Mariam , Durham Phillip , Hickey Anthony J.
Published: December 2023

CPZEN-45 is a novel compound with activity against drug-susceptible and drug-resistant tuberculosis (TB). The present study was undertaken to determine the best dose and dosing regimen of inhalable CPZEN-45 powders to use in efficacy studies with TB-infected guinea pigs. The disposition of CPZEN-45 after intravenous, subcutaneous (SC), and direct pulmonary administration (INS) was first determined to obtain their basal pharmacokinetic (PK) parameters. Then, the disposition of CPZEN-45 powders after passive inhalation using consecutive and sequential doses was evaluated. Plasma concentration versus time curves and PK parameters indicated that the absorption of CPZEN-45 after INS was faster than after SC administration (Ka = 12.94 ± 5.66 h−1 and 1.23 ± 0.55 h−1, respectively), had a longer half-life (2.06 ± 1.01 h versus 0.76 ± 0.22 h) and had higher bioavailability (67.78% and 47.73%, respectively). The plasma concentration versus time profiles and the lung tissue concentration at the end of the study period were not proportional to the dose size after one, two, and three consecutive passive inhalation doses. Three sequential passive inhalation doses maintained therapeutic concentration levels in plasma and lung tissue for a longer time than three consecutive doses (10 h vs. 3 h, respectively). Future studies to evaluate the efficacy of inhaled CPZEN-45 powders should employ sequential doses of the powder, with one nominal dose administered to animals three times per day.