bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Logging on the Ficus Community at Batu Timbang Research Station, Imbak Canyon Conservation Area, Sabah
Authors: Nakabayashi Miyabi , Bin Salam P.G Mohd Sahlan , Leung Lee Yew , Ahmad Abdul Hamid , Bin Battin Jeffery
Published: September 2022

We investigated the effect of logging on Ficus species at a community level in the Imbak Canyon Conservation Area (ICCA) in Sabah, Malaysian Borneo. We made comparisons of species composition, density, fig size, and host-tree size (DBH) between heavily logged and relatively old forests, and assessed factors affecting the size of hemi-epiphytic species. There were no significant differences in species composition, density, and fig size between the two habitats. There were significant differences between the DBH of host and non-host trees in both young and old forests as well as between those of host trees in young and old forests. The DBH of hemi-epiphytic species was negatively affected by the DBH of host trees. The results obtained in this study indicate that Ficus species, particularly hemi-epiphytes, can survive in degraded habitats that have recently been logged as well as in undegraded forests, and that their growth is not greatly affected by prior logging activities. Thus, Ficus exhibits both flexibility and adaptability to habitat change. This indicates that Ficus species make ideal plants for the restoration of logged forests considering that figs are an important food resource for numerous animal species, and can promote seed dispersal of other plants by attracting these animals into degraded habitats.
The occurence of Croton bonplandianus in Java and a new record of Caperonia palustris for Malesia Region
Authors: A. Anshori Zakaria , Irsyam Arifin S. D. , R. Hariri Muhammad , R. Irwanto Rina
Published: September 2022

Two noteworthy species belongs to the Euphorbiaceae, namely Caperonia palustris and Croton bonplandianus, have been recently collected from Java Island, West Malesia. The discovery of C. palustris is a new record for Malesia region, while C. bonplandianus is considered as a newly recorded alien species to the Flora of Java. Caperonia palustris is characterized by the glandular and non-glandular hairs on its stem and petiole, triangular to lanceolate or subulate stipules, and leaves in ovate-oblong or elliptic-oblong to lanceolate shape. Croton bonplandianus differs from the previously reported species in Java, C. hirtus, by its non-irritating hairs on the stem, sessile basal leaf glands, leaf margin with simple serration, and ellipsoid fruit. Descriptions and a brief discussion are given.
Studying the Impacts of Land Use Changes on the Occurrence of Vector Mosquitoes in Sabah, Malaysia
Authors: Jebrail Evyen Wevan , M. Dawood Mahadimenakbar
Published: September 2022

Land use changes as a result of infrastructural and agricultural development such as construction of forest field centre, establishment of large-scale oil palm plantations, and logging activities are increasing in Malaysia. These activities lead to environmental disturbances and may affect the ecological balance of many organisms. Mosquitoes are very sensitive to environmental changes since their diversity, distribution and abundance are influenced by even small changes in environmental conditions such as availability of suitable breeding sites. Mosquitoes from three different sites of varying disturbance levels at the SAFE Project experimental areas in eastern Sabah i.e., old growth forest (OG), logged forest (LFE) and heavily logged forest (Block B) were collected and identified to species level. Shannon-Wiener index and Simpson index of diversity were calculated and the diversity value were highest in LFE (H’= 0.4434, 1/D= 1.3427) and the least in Block B (H’= 0.3260, 1/D= 1.1627). A similar trend was detected in terms of mosquito abundance with the highest abundance recorded in LFE and the least in Block B. Results of the present study generally suggest that land use changes do affect mosquito diversity and abundance by altering, creating or providing places for the adult mosquitoes to breed.
Rapid Assessment of Nocturnal Sciurid and Avifauna Diversity in Kadamaian – Kinabalu Park for Ecotourism Potential
Authors: MN Arifuddin , M Izereen , T Fred , A Suganthi , VK Jayaraj
Published: September 2022

A rapid assessment of sciurids  and avifauna was done from 14th October 2020 – 20th October 2020 in Kadamaian – Kinabalu Park, Kota Belud, Sabah. Two sets of binoculars (Swarovski 8x30 and Bushnell 10x42) and two sets of Digital SLR cameras affixed with telephoto lens (Canon 7D; Tamron 150-600mm G2 F/4-6.3 and Nikon D500; Nikkor 200-500mm F/5.6) were used to aid in data collections. This assessment managed to record 5 species of Sciurids and 58 species of Avifauna in and around the Kadamaian-Kinabalu Park. Continuous biodiversity surveys are crucial in Kadamaian – Kinabalu, Sabah to maximize the potential ecotourism opportunity.
Dragonflies and Damselflies (Odonata) of Kadamaian, Kinabalu Park, Sabah
Authors: Chee Yen Choong , Mohamed Dawood Mahadimenakbar
Published: September 2022

The Odonata fauna of Kadamaian was surveyed from 15th to19th October, 2019 during the Borneo Geographic Expedition 2019 Kadamaian. The altitude of the survey area ranged from 400 m to 850 m above sea level, representing the lower part of Kinabalu Park. A total of 23 species in nine families were recorded – 10 species in Libellulidae, three species in Platycnemididae, two species each in Platystictidae, Calopterygidae and Coenagrionidae, and one species each in Chlorocyphidae, Devadattidae, Euphaeidae and Synthemistidae. Of these, only one species is a new record for Kinabalu Park – Pericnemis dowi. The published Odonata records were compiled to produce a species list known from Kinabalu Park. The total number of species known to Kinabalu Park is now 71. Many more parts in Kinabalu Park need to be explored for a more comprehensive Odonata fauna of the park.
KONSEP JIHAD ULAMA MELAYU-ISLAM DALAM KITAB JAWI TERPILIH: SATU ANALISIS
Authors: RAHIMIN AFFANDI ABD RAHIM  , SYAMSUL AZIZUL MARINSAH  , AHMAD FARID ABD JALAL
Published: September 2022

Sejarah Malaysia membuktikan perjuangan orang Melayu menentang penjajah di Tanah Melayu dilakukan oleh pelbagai pihak dan gerakan. Namun begitu, perjuangan golongan ulama dalam membebaskan Tanah Melayu daripada belenggu penjajahan kurang didedahkan. Justeru, objektif kajian ini cuba menganalisis konsep jihad ulama Melayu-Islam yang terkandung dalam kitab Jawi terpilih. Hal ini perlu bagi membuktikan peranan ulama Melayu Islam dalam menyemarakkan semangat nasionalisme seperti yang terkandung dalam fakta sejarah karya-karya kitab Jawi tersebut. Sehubungan dengan itu, kajian ini merupakan kajian kualitatif yang menggunakan metode pengumpulan data melalui kaedah kepustakaan dan analisis dokumen. Hasil kajian mendapati, peranan ulama Melayu-Islam dalam kebangkitan menentang penjajah terbukti, khususnya Ashab Jawi. Fakta sejarah dalam kitab Jawi yang dipilih membuktikan hal ini walaupun peranan mereka sering ditenggelamkan oleh paparan sejarah tajaan British. Mereka menonjolkan tokoh feudal Melayu sebagai pejuang kemerdekaan terawal. Pandangan palsu ini wajib diperbetulkan demi menimbulkan kebenaran dan menunjukkan dimensi jihad ulama Melayu bercirikan semangat keagamaan dan nasionalisme.
 
The history of Malaysia proves that various parties and movements carried out the struggle of the Malays against the colonialists in Malaya. However, the struggle of the ulama in liberating Malaya from the shackles of colonialism is less exposed. Thus, the objective of this study is an attempt to analyze the concept of jihad of Malay-Muslim scholars contained in selected Jawi books. This is necessary to prove the role of Malay Islamic scholars in igniting the spirit of nationalism as contained in the historical facts of the works of the Jawi book. Therefore, this is a qualitative study that employs data collection techniques such as library research and document analysis. The study results found that the Malay-Muslim scholarsplayed a signficant role in the uprising against the colonialists, specifically the Ashab Jawi. Historical facts in selected Jawi scriptures prove this even though their role is often over shadowed by British -sponsored historical displays. They highlighted Malay feudal figures as the earliest independence fighters. This false view must be addressed to reveal the truth and show the dimension of jihad of Malay scholars characterized by religious spirit and nationalism.
KI in der Produktion – Innovative Anwendungsfälle
Authors: Brecher Christian , Krüger Jörg , Uhlmann Eckart , Verl Alexander , Riedel Oliver , Lechler Armin
Published: September 2022

Der vorliegende Band dokumentiert die Aktivitäten der produktionstechnischen Institute aus Aachen (WZL/ IPT), Berlin (IWF/IPK) und Stuttgart (ISW) im Zusammenhang mit dem Thema „KI in der Produktion – Innovative Anwendungsfälle“ und gibt einen Ausblick auf mögliche Anwendungsfelder und Entwicklungsrichtungen dieses Themenbereichs. Im Rahmen der Entwicklungen von Anwendungen der Künstlichen Intelligenz in der industriellen Produktion werden Potentiale und aktuelle Grenzen aufgezeigt. Dabei wird insbesondere gezeigt, dass die Kombination von Expertenwissen mit Methoden der Künstlichen Intelligenz vielversprechende neue Ansätze bietet. Das reine Sammeln von Daten und die reine Anwendung von Algorithmen auf diese führt zu keinen hilfreichen Ergebnissen.

Inhalt

1 Neuronale Netze für die Berechnung optimaler Geometrieparameter für das Polynomüberschleifen ....1

B. Kaiser, A. Lechler, A. Verl und O. Riedel

2 Divide and Conquer-Prinzip für die KI-basierte Wiedererkennung von Altteilen in der Kreislaufwirtschaft ... 15

C. Briese, M. Schlüter und J. Krüger

3 Strategien zur Integration datengetriebener Ansätze für die Dynamik-modellierung von Industrierobotern ...27

L. Gründel, S. St...
The influence of emerging technologies on small and medium manufacturing enterprises in eThekwini District Municipality of KwaZulu-Natal
Authors:   , Lindokuhle Senamile Ntuli
Published: September 2022

Manufacturing Small and Medium Enterprises (SMEs) in South Africa (SA) contribute meaningfully to economic growth, poverty reduction, social stability and job creation. Research on the influence emerging technologies have on SME has been conducted all over the world; however, few studies focused on the manufacturing sector, with specific reference to the eThekwini District Municipality. Therefore, this research study aims to explain and clearly define the factors that influence manufacturing SMEs in the eThekwini District Municipality towards adoption of emerging technologies, in order to enhance productivity and business processes which, in turn, result in improved customer satisfaction. Furthermore, this study examines how emerging technologies influence SMEs operating in the eThekwini District Municipality. The factors influencing adoption of emerging technologies among manufacturing SMEs in eThekwini remain unclear. This study aims to investigate the influence emerging technologies will have on the manufacturing SMEs operating in the eThekwini District Municipality. Data were collected from the sample of 300 manufacturing SME owners/managers in the eThekwini District Municipality, selected by means of non-probability stratified sampling, with respondents completing a questionnaire with the support of the researcher. The study used quantitative techniques. Results from the questionnaire survey reveal that most manufacturing SMEs in the eThekwini District Municipality who were respondents in the study are still at an infant stage with emerging technologies, due to financial constraints and lack of skills expertise associated with the cost of emerging technologies. However, these small enterprises do consider the use of emerging technologies such as computer devices, the cloud and emails to gain competitive advantage and improve production. Further research should aim to establish training programmes that will offer manufacturing SMEs emerging technologies skills and encourage the use of emerging technologies as the world is changing with technologies so they can be innovative.
TO QUESTION ABOUT QUALITY OF EDUCATION IN MEDICAL SCHOOL
Authors: Podolyako V. A. , Lyzikov A. N.
Published: September 2022

The questions, that concern to quality of prepation doctor for highest medical school, had been considered in this article. The levels of control quality of education for future doctor had been produced.
THERAPEUTIC OPPORTUNITIES OF NASAL IRRIGATION
Authors: Sitnikov V. P. , Bisunkov A. B. , Voronovich V. P.
Published: September 2022

The article discusses the methods of nasal irrigation most frequently used in clinical practice, modern technical devices applied for the procedure are described. Recent approaches to explaining the mechanisms of therapeutic activity of nasal lavage are given. The article contains the results of randomized controlled clinical trials devoted to effectiveness of nasal irrigation in the patients with acute and chronic rhinosinusitis, atrophic rhinitis and allergic rhinosinusopathy associated with bronchial asthma.
VARIABILITY OF N-ACETYLTRANSFERASE PHENOTYPE IN THE CITIZENS OF GOMEL AND GOMEL REGION
Authors: Satyrova T. V. , Mihailova E. I. , Osipenko A. N. , Osipenko N. B. , Vasenda M. N.
Published: September 2022

The variability of N-acetyltransferase phenotype by 129 Caucasoids, citizens of Gomel and Gomel region has been studied. The phenotype of acetylation has been estimated at the ratio of concentrations of acetylated and free isoniazids, which have been determined by means of high-performance liquid chromatography. The presence of trymodal distribution of the acetylated phenotype has been determined. The ratio of slow and quick acetylators in the population makes 66 and 34 % correspondingly. The statistic interaction of the acetylated phenotype has not been proved neither with sex (τ = -0,047, р = 0,42) or age (τ = -0,004, р = 0,94), nor with body weight (τ = -0,01, р = 0,86) and the examined volunteers` addiction to smoking (τ = -0,112, р = 0,08).
ESTIMATION OF THE CURRENT CONDITION OF THE FUNCTIONAL AND PHYSICAL FORM OF SPORTSMEN APPLICATION OF THE HARDWARE-SOFTWARE COMPLEX «OMEGA-S»
Authors: Shilovich L. L.
Published: September 2022

The analysis of indicators of a functional and physical condition of sportsmen according to a complex «Omega-with» is presented. The analysis of data has shown a good associativity of processes level of the sports form power maintenance and a psychoemotional condition. The integrated indicator of the sports form corresponds to an estimation «good».
PECULIAR PROPERTIES OF THE HUMAN SKIN STRUCTURE UNDER MELANOMA
Authors: Grushin V. N. , Belikova I. S. , Myadelets O. D. , Kichigina T. N. , Zubareva I. V. , Abletsova U. P.
Published: September 2022

The main object of the study is the derma of humans who suffer from melanoma. The researches were carried out with the implementation of histological equipment and light microscopy. Both usual and special procedures were used for coloring of histological specimen. In the structure of melanoma the attention was paid on the general structure of epidermis and dermis tissue, on the morphology of melanocites and melaniferous, their location and the degree of these cells’ melanization.
THEORETICAL BASES OF ATHEROSCLEROSIS’ ADSORPTIONAL THERAPY
Authors: Lysenkova A. V. , Philippova V. A. , Prischepova L. V. , Odintsova M. V.
Published: September 2022

The goal of the given investigation was to study the effectiveness of adsorption therapy applied to treat and prevent atherosclerosis. The kinetics of cholesterol adsorption from water-alcohol solutions prepared by ultrasonic degradation method was under study. Activated carbon and micro cellulose wide applied in medicine as entero- and hemosorbents were used to bind and remove cholesterol from model solutions. In order to give quantitative description for the adsorption process the rate constants of adsorption and desorption, the equilibrium constant of adsorption, the maximum adsorption and the degree of cholesterol excretion were calculated. The studying of calcium, magnesium, copper and ascorbic acid adsorption at activated carbon and micro cellulose made it possible to appreciate the side effects of adsorption therapy. The investigation revealed that effectiveness of activated carbon for treating and preventing atherosclerosis is greater than that of micro cellulose.
HETRBAL PREPARATIONS FROM MILK THISTLE: NEW FIELDS OF APPLICATION
Authors: Brel Y. I. , Lyzikov A. N. , Pitkevich E. S.
Published: September 2022

Nowadays the increase of experimental and clinical investigations associated with the discovery of new properties of herbal preparations from Milk Thistle is observed. The anticancer activity of the main active component of this herbal drug - silymarin - is studied. This review demonstrates possibilities of Milk Thistle clinical use in different pathological states.
THE CASE OF SARCOMA KAPOSI AT THE NINE-MONTH OLD HIV-INFECTED CHILD
Authors: Mishin A. V. , Zinovkin D. A. , Nadyrov E. A. , Loginov R. A. , Doroshenko R. V.
Published: September 2022

In this article the case of sarcoma Kaposi at a HIV-infected 9-th month old girl in which the tumour was characterised by absence of dermal implications, by a generalised lesion of lymph nodes and not characteristic for implications at children of the given tumour in a thymus and a lien is described.
REGENERATIVE TREATMENT OF TRAUMAS OF THE HUMERAL JOINT
Authors: Nikolaev V. I. , Divovich G. V. , Latysheva V. J.
Published: September 2022

Damages of a humeral joint and their consequence are the widespread pathology as meet at 1/5 parts of the population, half from which - persons of able-bodied age. It results to significant work-loss and to infringement of quality of a life of patients. Complexity of a structure of humeral joint causes the certain difficulties in diagnostics and treatment of the given category of patients. Existing traditional methods of treatment include the certain term rigid immobilization and the subsequent long rehabilitation. Work is directed on studying of methods of rehabilitation with the purpose of a finding of variants immobilization the hands, allowing to begin movements in a humeral joint already during the period plaster fixation with use of new technologies and elements of ergotherapy.
INFLUENCE OF MAGNETIC-LASER THERAPY ON THE EFFECTIVENESS OF THE REHABILITATION OF PATIENTS WITH MYOCARDIAL INFARCTION IN EARLY RESTORATIVE PERIOD
Authors: Sobchenko I. Y. , Kovalchuk P. N. , Barbarovich A. S.
Published: September 2022

The results of experimental and clinical investigations are evidence of the positive influence of magnetic-laser therapy on the restorative treatment of patients with ischaemic heart disease. The combination of the impact of laser therapy and magnetic field affords a possibility to increase the treatment effect. The effectiveness of medical rehabilitation of postinfarctic patients in early restorative period by the supravenous magnetic-laser illumination of blood has been shown. It has been ascertained, that the method of magnetic-laser therapy is economically profitable and perspective, conducive to the decline of atherosclerosis progression and decrease of the dosage of antianginal preparations.
METHOD OF EARLY DIAGNOSTICS OF THYROID PATHOLOGY
Authors: Dvornik A. M. , Bortnovsky V. N.
Published: September 2022

In the article the simple economical method for monitoring the dynamics of development of thyroid cancer in children of school age, which lies in the fact that for every child of school age are calculated size of the thyroid gland according to the formulas defined for different regions (provinces) of Belarus and the comparison with the corresponding nomograms for assessment of the thyroid gland.
RESEARCH OF METABOLIC PARAMETERS IN THE ORGANISM OF EXPERIMENTAL ANIMALS AT INFLUENCE OF THE EXTERNAL IRRADIATION
Authors: Gritsuk A. I. , Myshkavets N. S. , Fomchenko N. E.
Published: September 2022

The papir results of research of biochemical parameters in whey of blood of albino rats in conditions of influence of an external irradiation in a doze 0,5 and 1 Gy are submitted. The analysis of dependence of various biochemical parameters from a doze and time of an external irradiation is lead.
CONDITION OF SECONDARY HEMOSTASIS IN CHILDREN WITH PURPURA RHEUMATICA
Authors: Hoduleva S. A. , Romashevskaya I. P. , Demodenko A. N. , Novik D. K. , Borodina G. Yu. , Kireeva T. I. , Zhuk O. V.
Published: September 2022

There was performed the incidence analysis of purpura rheumatica among children aged 3-16 for the period of January, 2005 - January, 2009. For the analyzed period there were diagnosed 42 cases. Children aged 6-13 are mostly the purpura rheumatica disease inclined (65 %), the girls and boys become ill with identical frequency. The acute course was registered in 66,7 % of cases. More often the isolated skin form is developed (38 %), light and average disease severity (88,5 %). The secondary hemostasis condition in children with purpura rheumatica is charachterized by mixed changes: hypocoagulation by activated partial thromboplastin time, by thrombin time and prothrombin index; hypercoagulation by fibrinogen level and INR. Changes in coagulogram and degree of their expressiveness depend on the clinical form of disease, severity level and variant of course.
INFLUENCE OF THE UNITALY PUNCTURAL ASPIRATION ON THE CELLULAR POPULATIONS OF THE PSEUDOCYST OF THE PANCREAS (experimental research)
Authors: Doroshkevich S. V. , Doroshkevich E. Yu. , Zhdanovich V. N.
Published: September 2022

The purpose of the research is to learn the cellular populations of neutrophiled leucocytes, macrophages, fibroblasts and lymphocytes in the system of copulative tissue of the side of the pancreas after the punctural aspiration with the usage of quantitative methods. Local cold influence of the pancreas of white rat with the help of cryosurgical complex KCH 3A/B was used for the modeling of the pseudocyst. The puncture of the pseudocyst was made on the 14th day of the experiment. The punctural aspiration of the contents of the pseudocyst is accompanied by macrophagal reaction. The increase of the quantity of fibroblasts and lymphocytes is watched. The general decrease of the contents of cells in the side of the pseudocyst mainly at the expense of reduction number neutrophiled leucocytes is watched.
EFFECT OF BIMITHYL ON THE SPECIFIC ESTRADIOL BINDING BY CARDIOMYOCYTES OF RATS IN THE CONDITIONS OF IONISING RADIATION AND STRESS
Authors: Melnik S. N.
Published: September 2022

It has been ascertained, that the stress influence on the contents of specific receptors for estradiol in rats` myocardium becomes evident to its maximum extent on the third day, reliably decreasing this index. The external γ-irradiation statistically increases the number of receptors for estradiol in the myocardium on the tenth day. The complex effect of the immobilizing stress and ionising radiation reliably decline cytoplasmic fraction of myocardial receptors for estradiol to 75 % on the 30th day. The application of bimithyl allows compensation of the effects, induced by the acute immobilizing stress and ionizing radiation.
ALCOHOL CONSUMPTION AND ALL-CAUSE MORTALITY IN BELARUS
Authors: Razvodovsky Y. E. , Norstrom T. .
Published: September 2022

The aims of the present study were: to estimate the effect of per capita alcohol consumption on all-cause mortality in Belarus and to compare the alcohol effect for Belarus with that found for other countries. Annual data on male all-cause mortality and alcohol sale per capita for the period 1970-2005 were analysed using the Box-Jenkins technique. Female mortality was included as a control variable and regarded as a proxy for other causal factors. The outcomes suggest that a 1-litre increase in consumption was associated with an increase in male all-cause mortality of about 2,3 %. The present study strengthens the notion of alcohol consumption as an important determinant of population health , and thus the notion that alcohol control must be a key priority for Belorussian public health policy.
COMPARISON OF MOLECULAR-GENETIC TECHNIQUES, HISTOLOGICAL AND IMMUNOHISTOCHEMICAL METHODS OF ANALYSIS FOR CONTROL OF ERADICATION OF НELICOBACTER PYLORI -INFECTION
Authors: Voropaeva A. V. , Voropaev E. V. , Achinovich C. L.
Published: September 2022

Helicobacter pylori detection after its eradication by polymerase chain reaction, immunohistochemical, morphological methods have been studied, the sensitivity and specificity of the methods have been determined. Treatment effectiveness should be monitored by PCR, which has high sensitivity (84 %) and specificity (100 %), simplicity and low cost compared with other methods described in this article.
EXCLUSION OF VARIOUS SEGMENTS OF DEEP VEINS IN LOWER EXTREMITIES FROM BLOOD FLOW: OUTCOMES AND PROGNOSIS
Authors: Lyzikov A. A.
Published: September 2022

The report is dedicated to the study of acute venous thrombosis. The aim of the research was to reveal the disease outcomes depending on the localization and length of occlusion of various segments of deep veins in lower extremities for determination of possibility of surgical harvesting of the veins. 91 patients treated at Gomel vascular surgery department from 2004 to 2005 were examined. There were 54 man and 37 woman aged from 17 to 88 years. The acute venous thrombosis has been diagnosed basing on clinical manifestations and essential ultrasonic control. The research is mixed in its character: patients selection was performed on retrospective basis and further observations were prospective. The clinical pattern of the disease was studied depending on occlusion level. Demographic characteristics were analyzed. In the article thtre is a description of the outcomes of acute occlusions after a half of year. Results of standard treatment are revealed.
POSSIBLE MISTAKES IN THE ANALYSIS OF HEART RATE VARIABILITY
Authors: Ban A. S. , Zagorodny G. M.
Published: September 2022

In the article are being discussed the factors, influencing to the variables of the heart rate variability records. The knowledge of them allows to prevent mistakes of the heart rate variability analysis. The results of own study and literature data are given.
PREDICTIVE SIGNIFICANCE OF IMMUNOGRAM INDICES IN THE ESTIMATION IMMUNOMODULATING THERAPY EFFECTIVENESS IN PATIENTS WITH CHRONIC RECURRENT FURUNCULOSIS
Authors: Gomoliako A. V. , Novikova I. A. , Salivonchyk A. P.
Published: September 2022

The significance of immunogram indices for prediction of immunomodulating therapy effectiveness in patients with chronic recurrent furunculosis has been evaluated. It has been ascertained that the predictors of favorable prognosis are a decrease of stimulated NO production levels at normal levels of basal NBT-test and unchanged concentration of CD3+16/56+-cells. The predictors of unfavorable prognosis of effectiveness are an increase of basal NBT-test levels, decrease of CD3+16/56+-lymphocytes concentration and of neutrophils ability for stimulated NO production.
NEURORETINOPROTECTIVE EFFECT OF CORTECSIN AND RETINALAMIN TREATMENT OF OPEN-ANGLE GLAUCOMA
Authors: Razhko Yu. I. , Marchenko L. N. , Rebenok N. A. , Krivun A. O. , Dravitsa L. V. , Belkevich Yu. L. , Bobr T. V. , Lenkova Zh. I. , Glushko D. P.
Published: September 2022

39 patients with open-angle glaucoma of I-III stages were recruited into the research aimed at the definition of neuroprotective effect of Cortecsin and Retinalamin preparations. The period the consisted of parabulbar injections of Retinalamin and intramuscular injections of Cortecsin. The time of observation was 6 months. The morphometric and electrophysiological methods have confirmed that the thickness of nerve fibers layer of retina, the area of neuroretinal zonule, the amplituden and latency of a- and b-waves of electroretinogram increase and the diameter of excavation decreases. The profile of effectiveness, safety and tolerance for the preparations allows assuming that they are right as means of the first row for various therapeutic modalities in patients with glaucoma.
FATAL OUTCOMES ASSOCIATED WITH CHRONIC ALCOHOLIC INTOXICATION: TOPICAL ISSUES OF MORPHOLOGICAL DIAGNOSIS AND MEDICAL STATISTICS
Authors: Grishenkova L. N. , Antipova S. I. , Smolensky A. Z. , Metelskaya M. A.
Published: September 2022

The article presents the results of the retrospective study of 178 alcohol-related fatal disease cases based on the clinical records (2009) submitted by the Municipal Clinical Pathologic Bureau (Minsk). All the fatal outcomes have been studied in terms of the patients’ age, gender and nosological forms. Both the clinical and pathological diagnoses have been analyzed. The main difficulties of the morphological diagnostics and medical statistics of alcohol-related pathology have been ascertained and possible ways to bridge them over have been suggested.
INFLUENCE OF SULFASALAZINE ON A HOMEOSTASIS OF SYSTEM OF BLOOD AT PATIENTS WITH ULCERATIVE COLITIS
Authors: Afonin V. Y. , Satyrova T. V. , Mikhailova E. I.
Published: September 2022

With use of a method flowing cytometry at 50 patients with ulcerative colitis influence of sulfasalazine on a homeostasis of system of blood depending on activity of N-atsetyltransferase 2 (NAT2) is studied. It is established, that in system of peripheral blood at patients with ulcerative colitis with rapid acetylator phenotype standard doses of sulfasalazine did not influence level pathological apoptosis. Thus apoptosis it was accompanied by modulation of inhibition influences of sulfasalazine on cellular proliferation by means of braking of a G1-phase of a cellular cycle. At slow acetylator phenotype standard doses of sulfasalazine initiated the tendency to interruption of pathological apoptosis. However decrease in survival rate of cells of peripheral blood owing to reception sulfasalazine at low activity of NAT2 at patients with ulcerative colitis occurred at the expense of blocking a S-phase of a cellular cycle and increase in formation of cells with micronuclei.
COMPARISON OF LIFE QUALITY OF PATIENTS WITH CHRONIC OBLITERATING DISEASES OF LOWER EXTREMITY ARTERIES AFTER INDIRECT REVASCULARIZATION AND CONSERVATIVE THERAPY
Authors: Petukho A. V.
Published: September 2022

The analysis of life quality of 74 patients suffering from chronic obliterating diseases of lower extremity arteries has been carried out. Of them, 40 patients underwent conservative treatment and 34 - indirect revascularization. The analysis was carried out by way of mail questioning. The questionnaire, adapted by V. V. Savin for the patients suffering from chronic obliterating diseases of lower extremity arteries, was used as the inquiry form. The data obtained were analyzed by means of the life quality score in accordance with the scale of the questionnaire developer, using the methods of obtaining integral life quality characteristics, and analysis of certain questionnaire scales. None of the 40 patients, undergoing conservative treatment, revealed good life quality, 11 patients (27,5 %) revealed satisfactory life quality and 29 patients (72,5 %) - unsatisfactory. The study of the similar indices in the patients who had undergone the operations of indirect revascularization identified good life quality in 1 case (2,94 %), satisfactory in 14 patients (41,18 %) and unsatisfactory in 19 patients (55,88 %).
EFFECT OF GLUCOSE CONCENTRATION ON THE LEVEL OF PROBE FLUORESCENTION OF BULL AND SERUM ALBUMINS
Authors: Avdeev P. A. , Gnatenko V. A. , Kornoushenko Yu. V.
Published: September 2022

The rise of glucose concentration in protein solutions gives a decrease in intensity indices of probe fluorescention. This change of probe fluorescention is most probably caused by the decreased quantity of ANS binded with the protein. Thus, one can suppose that the rise of glucose concentration in blood initiates the decrease in albumin binding capacity towards other ligands. The rise of glucose concentration makes the intensity indices of protein fluorescention decrease. The ability of glucose to bind with protein initiates the rearrangement in globule electron density, which promotes intramolecular conformational changes in protein and the decrease of the intensity indices of tryptophan fluorescention to testify that.
FACULTY OF MEDICAL DIAGNOSTICS: COMMENCEMENT OF GREAT WAY (DEDICATED TO THE 20-YEAR ANNIVERSARY OF THE GOMEL STATE MEDICAL UNIVERSITY)
Authors: Lyzikov A. N. , Kalinin A. L. , Tarasyuk I. V. , Novikova I. A. , Butenkova E. M.
Published: September 2022

The article contains the main information about the history of foundation, organization of work, training of specialists, perspectives of the development of the Faculty of Medical Diagnostics in the Gomel State Medical University.
MEDICAL ORGANIZATIONAL TECHNOLOGIES AIMED AT THE DECREASE IN MORTALITY FROM BLOOD CIRCULATION DISEASES OF ABLE-BODIED POPULATION
Authors: Lopatina A. A. , Sharshakova T. M.
Published: September 2022

Taking into account the regional specific features and tendencies the authors have studied in detail the regional peculiarities of death causes and have suggested the organizational approaches to decrease the mortality rate of able-bodied population from the diseases of blood circulation system.
QUALITY ASSESSMENT OF INFLUENCE OF LOW-FREQUENCY ELECTROMAGNETIC RADIATION ON PRENOSOLOGICAL STATUS OF STUDENTS
Authors: Mamchits L. P. , Klimovich S. V.
Published: September 2022

This paper is dedicated to the study of prenosological status of students under influence of low-frequency electromagnetic radiation. The hygienic description of main external and internal sources of low-frequency electromagnetic fields has been given; subjective reaction of organism to low-frequency electromagnetic fields in real living conditions with the use of physiological and hygienic research methods has been studied.
METOD AND DEVICE FOR VIBROMECHANICHEL MEMORY STIMULATION UNDER EXTREMAL PSYCHONEUROLOGICAL LOADS
Authors: Sagaidak D. I. , Shilko S. V.
Published: September 2022

The method and positive experience of biomechanical stimulation using developed vibrotrainer «Stimul», expressed as reliable improvement of cognitive characteristics, have been described.
FORECASTING OF INTERFERON THERAPY EFFICIENCY IN PATIENTS SUFFERING FROM CHRONIC HEPATITIS C WITH VARIOUS HCV GENOTYPES
Authors: Krasavtsev E. L. , Mitsura V. M. , Demchilo A. P.
Published: September 2022

The virologic response was evaluated in patients suffering from chronic hepatitis C with various hepatitis C virus (HCV) genotypes depending on detection frequency of antibodies to HCV NS5 protein and antibodies to HCV of IgM class, cytokines IFN-γ IL-2, IL-4, IL-1α, TNF-α serum levels in various terms of interferon therapy. The prognostic value of anti-NS5 negative test and anti-HCV IgM positive test, high levels of proinflammatory cytokine IL-1α and IL-4 for the assessment of the interferon therapy efficiency was shown.
CYTOGENETIC CHANGES IN CAGES OF SYSTEM OF BLOOD AT PATIENTS WITH ULCERATIVE COLITIS AGAINST TREATMENT BY SULFASALAZINE
Authors: Mikhailova E. I. , Satyrova T. V.
Published: September 2022

Cytogenetic changes in cages of peripheral blood at 62 patients with ulcerative colitis (UC) against standard treatment by sulfasalazine with use of a method of light microscopy are studied. It is established, that sulfasalazine in standard doses at patients with UC with fast type acetylation promoted accumulation neutrophils with presence of high level of segmentation, neutrophils in final phases of development and did not interrupt progressing of the basic pathogenetic link of this disease - аpoptosis. At slow acetylator with UC standard doses of sulfasalazine allowed to reduce formation neutrophils with presence of low level of segmentation, neutrophils on initial phases of development and promoted interruption pathological аpoptosis, disease causing development, i. e. UC.
COMPARATIVE EVALUATION IDENTIFICATION OF INFLAMMATORY BOWEL DISEASE AND TUMOR ON THE BASIS OF LACTOFERRIN AND CALPROTECTIN
Authors: Mikhaylova E. I. , Filipenko N. V.
Published: September 2022

The study was a comparative evaluation of the identification of inflammatory bowel disease and tumor on the basis of fecal lactoferrin and fecal calprotectin. 40 patients with colorectal cancer, 52 patients with ulcerative colitis, 45 patients with irritable bowel syndrome and 19 healthy volunteers are included in study group. Diagnoses were exposed on the basis of clinical, laboratory, endoscopic and morphological data. Healthy volunteers had no symptoms of bowel disease and were not subjected to abdominal surgical interventions. Active ulcerative colitis was assessed by an index Schroeder (Mayo Clinic UC DAI). Lactoferrin was determined in stool samples taken from a stool, enzyme immunoassay (ELISA) using kits ELISA TEST KIT Hycult Biotechnology (Netherlands). Calprotectin were determined in stool samples of patients taken from a stool, immunnofermentnym analysis using a standard set of firm «Nova Tec Immundiagnostica GmbH», Germany. Established that the diagnostic value of faecal calprotectin in the diagnosis of colorectal cancer (AUC: 0,945 ± 0,0262) and ulcerative colitis (AUC: 0,893 ± 0,032) did not differ from lactoferrin (p = 0,9547 and p = 0,9645 respectively). In the differential diagnosis of organic and functional bowel disease markers also had no reliable statistical differences on this parameter (AUC: 0,938 ± 0,0207; p = 0,8124).
MODERN PRINCIPLES OF CLASSIFICATION, PROGNOSIS AND TREATMENT OF PRIMARY MYELODYSPLASTIC SYNDROMES
Authors: Klimkovich N. N.
Published: September 2022

Article is devoted myelodysplastic syndromes (MDS). It is group malignant diseases of a bone marrow in which basis the pathology hаemopoetic stem cells, leading to infringement proliferations and differentiations of hаemopoetic cells - predecessors with their change morphological and functional properties. Development of ordering MDS by variants, in particular, new classification the WHO (2008) is described. The estimation prognostic parametrs and systems is spent. Modern sights at treatment MDS with the account are presented an individualization of therapy on the basis of prognostic factors. The characteristic of new medical products and the analysis of results of application of standard therapeutic schemes in various modes and combinations is given.
GASTROESOPHAGEAL REFLUX IN CHILDREN (literature review)
Authors: Kozlovsky A. A. , Lozovik S. K. , Pokulnevich N. A.
Published: September 2022

The disease of gastroesophageal reflux in children stays to be one of the actual topics not only for clinicians but also for researchers. The high prevalence and frequent relapses of the given pathology makes for the topicality of the problem. In view of that, the present-day diagnostics for gastroesophageal reflux and adequate treatment make it possible to improve the prognosis for the disease and to decrease the process chronization rate.
FEATURES OF LOCAL IMMUNITY IN PATIENTS WITH RECTAL CANCER AFTER RADICAL TREATMENT
Authors: Nadyrov E. A. , Ugolnik T. S. , Achinovich S. L. , Chubukov Zh. A. , Chubukova T. N.
Published: September 2022

Rectal cancer is one of the topical problems of modern oncology. The analysis of the differences in clinical, morphological and histochemical indicators in the groups of patients from Gomel region, which underwent different types of treatment for cancer of the rectum I-III stages has been carried out. A number of indicators revealed statistically significant differences. The survival analysis in the investigated groups was performed.
METABOLIC INTOXICATION EFFECT ON INDIVIDUAL TIME PERCEPTION INDEX IN PATIENTS WITH HEMOPHILIA
Authors: Anoshina M. Yu. , Yuschenko P. V. , Semenyaka V. I. , Yagodvik M. V. , Averianov E. V. , Burnayeva S. V. , Assa O. V.
Published: September 2022

The research results of the interrelation between the indices of metabolic intoxication and individual time perception (individual minute) in 112 patients with hemophilia with haemorrhages of various localization have been presented. It has been ascertained, that the indices of lipid peroxidation and permeability of erythrocytic membranes are criteria that make it possible to assess the ability of an organism for adaption. The index of individual time perception may serve as a marker for metabolism changes in hemophilia patients` organism, which allow of considering it as an additional assessment criterion for the clinical course and cure rate.
RISK FACTORS FOR THE DEVELOPMENT OF HEMORRHAGIC SYNDROME IN NEONATAL PERIOD
Authors: Kozlova E. L. , Klimkovich N. N.
Published: September 2022

The problem of hemostasis disturbances in neonatology gains currency due to its physiological instability aggravated by various pathologic processes. Based on literary data, the article systematizes the causes that lead to the disturbance of hemostasis functioning in the neonatal period and characterizes the risk factors for hemorrhagic complications from the neonate and the mother. It has been shown that the state of microcircular hemostasis in the neonates demands its detailed investigation, as the received knowledge about the functioning of primary hemostasis will make it possible to decide a lot of important issues that relate to the disturbance correction in hemorrhagic syndrome in the neonates.
EXPERIENCE AND PROSPECTS OF THE CLINICAL APPLICATION OF MESENCHYMAL STEM CELLS
Authors: Krivenko S. I. , Uss A. L. , Dedyulya N. I.
Published: September 2022

Tandem transplantation of hemopoeitic and mesenchymal stem cells is a perspective and now widely used direction of cell therapy of oncohematological diseases and multiple sclerosis in the clinical practice of the Republic of Belarus. Mesenchymal stem cells are also effectively used as concomitant immunosuppressive therapy of acute and chronic reaction Transplant Against Host (RTAH). The protocols of the application of mesenchymal stem cells for the therapy of oncohematological patients and patients with multiple sclerosis are approved by the Ministry of Public Health Care of the Republic of Belarus. The efficacy of the cell therapy with the use of mesenchymal stem cells is studied in the clinical research in the treatment for various diseases: genetic degenerative diseases of skeleton, ischemic disease, liver cirrhosis, neurodegenerative diseases (parkinsonism, Alzheimer's disease). The experimental work and clinical trials have shown the positive effect of the transplantation of mesenchymal stem cells in myocardial infarction and in the substitutive therapy of liver impairment.
EFFICACY OF THE COMBINED APPLICATION OF HEMOPOIETIC GROWTH FACTORS AFTER STEM HEMOPOIETIC CELL TRANSPLATATION
Authors: Kuzmich E. A. , Zmachinsky V. A. , Milanovich N. F. , Novosiolova N. A.
Published: September 2022

The restoration of hemopeisis indices after high dose chemotherapy with autologic and allogenic transplantation of stem hemopoeitic cells with the combined use of hemopoietic growth factors - erythropoietin and granulocytic colony-stimulating factor at the early post-trasplantation period has been studied. 268 patients were included into the investigation. The shortening of restoration terms of hemoglobin, leucocytes and neutrophils in the group of patients, undergoing the combined therapy of hemopoietic growth factors after autologic transplantation of stem hemopoeitic cells. The shortening of restoration terms of hemoglobin, leucocytes and neutrophils in the group of patients, undergoing the combined therapy of hemopoietic growth factors after allogenic marrow transplantation. In whole, the application of erythropoietin in the combination of with granulocyte colony-stimulating factor led to the decreased hematologic toxicity.
ROLE OF AQUAPORIN-DEPENDENT MEMBRANE-TRANSPORT MECHANISMS IN THE REGULATION OF ERYTHROCYTE STRUCTURAL FUNCTIONAL CHARACTERISTICS IN ANEMIAS OF VARIOUS GENESIS
Authors: Peshnyak Zh. V. , Shpak G. A. , Smirnova L. A. , Rachitskaya V. V. , Truhan A. L. , Ustinovich Yu. V. , Tumar E. M. , Kravchuk Z. I.
Published: September 2022

The participation of aquaporin-1 (AQP-1) in the regulation of erythrocyte structural metabolic features in anemias of various genesis has been studied. It has been ascertained that the patients with asiderotic anemia (n = 6) have a 36 per cent decrease in the erythrocyte aggregation speed in comparison with the control group (n = 12). AQP-1 inhibition and AQP-1 combined suppression and phospholipase-dependent membrane mechanisms lead the increase in the erythrocyte aggregation speed till the level of the control group. The received results are evidence of AQP-1 participation in the regulation of erythrocyte structural metabolic features in the patients with anemias.
H- AND L-FERRITINS IN ACUTE LEUKEMIA
Authors: Smirnova L. A. , Kravchuk Z. I. , Kozich Zh. M.
Published: September 2022

We have studied H- and L-subunits of ferritin in acute leukemia. Our data makes it possible to suggest that the appearance of considerable numbers of ferritin in the serum of patients with clonal blood diseases is connected with its secretion with lymphocytes. As it is impossible to establish the reliable correlation between the dimension of the tumor in leukemia and the level of ferritin, then the ferritin secretion is hypothetically relating to its regulatory functions. We have shown that the separate testing of H- and L-forms of ferritin makes it possible to determine the content of serum ferritin. It has been established that the content of serum ferritin differs in acute leukemia at attacks and remission but it is necessary to accumulate the data for the comprehension of true diagnostic H-ferritin value. It is possible that in the nearest future hematologic syndromes in malignant tumors, i.e. clonal processes from the inflammation-associated syndromes, can be differentiated according to the content of serum ferritin.
HEREDITARY MICROTHROMBOCYTE THROMBOCYTOPATY: DIAGNOSIS AND TREATMENT
Authors: Vasiliev S. A. , Vinogradov V. L. , Oriol E. B. , Berkovskiy A. L. , Sergeyeva E. V. , Mazurov A. V. , Karabudagova Z. K.
Published: September 2022

The group of patients with hereditary microthrombocyte thrombocytopaty has been studied. The diagnostic criteria for this form of thrombocyte pathology have been determined, the effective methods of the treatment have been shown.
STATE AND PROSPECTS OF THE HEMATOLOGICAL SERVICE IN THE REPUBLIC OF BELARUS
Authors: Uss A. L. , Kushnirenko V. S. , Milanovich N. F.
Published: September 2022

The article presents the results in the analysis of the quality of specialized medical assistance to patients with hemopoietic diseases in the Republic of Belarus. The structure of the hematological service, availability with bed fund, specialists, laboratory equipment have been described. The results of the analysis revealed the necessity to perform the restructuring of the service. To improve quality and accessibility of the medical assistance to the patients with hemopoietic pathology and to introduce up-to-date treatment technologies, the prospects for the development have been determined, concrete suggestions to optimize the structure of the service have been given.
CAUSATIVE AGENTS OF INFECTIVE INFLAMMATORY COMPLICATIONS IN PATIENTS WITH ACUTE MYELOID LEUKEMIA
Authors: Fedorovskaya E. A. , Melnik E. A. , Skachkova N. K. , Rybalskaya A. P. , Nemirovskaya L. N.
Published: September 2022

The causative agents of infective inflammatory complications in 42 patients with acute myeloid leukemia have been detected. Their sensitivity to antibiotics and antimicotics was studied, and according to which the etiotropic infectious treatment was carried out. The individually selected antibiotic therapy made it possible to arrest in proper time the inflammation nidi, which did not impede the subsequent treatment of the patients.