bluuebunny/crossref_metadata_2025 huggingface dataset:
Glyceryl Trinitrate, a Vasodilating Drug Acts as an Antibiofilm Agent in Serratia marcescens
Authors: Al-Fayyadh Ziyad Hameed , Turki Ahmed Mohammed , Al-Mathkhury Harith
Published: July 2023

Objectives: Serratia marcescens is a gram-negative pathogen of many species. The ability of S. marcescens to form biofilms and its potent innate resistance to antimicrobials and cleaning solutions are both essential for its pathogenicity and survival. The present study was conducted to investigate the effect of glyceryl trinitrate (GTN) on the biofilm of S. marcescens, as an alternative for antibiotic therapy.

Methods: Different specimens, including ear swabs, burns, mid-stream urine, wound swabs, and sputum, were collected from patients who were brought to Al-Ramadi Hospital, Iraq. All samples were cultured, and the colonies that were obtained were detected using the VITEK® 2 compact. The ability of biofilms to develop was examined using the microtiter plate technique. The bactericidal effectiveness of GTN was estimated by the broth microdilution technique. The presence of fimA and fimC in S. marcescens isolates was detected using the polymerase chain reaction (PCR) method. Quantitative real-time polymerase chain reaction (qRT-PCR) was used to assess the effect of GTN on fimA and fimC gene expression.

Results: The results demonstrated that GTN has no effect on S. marcescens growth; while its biofilm was significantly (p<0.05) influenced. Moreover, all S. marcescens isolates had fimA and fimC, and the presence of GTN reduced the expression of these genes.

Conclusion: The findings of this study reveal that GTN can act as a promising antibiofilm agent in reference to S. marcescens.
THE END OF THE POST-INDUSTRIAL “VACUUM” MANAGEMENT OR ABOUT THE CRISIS OF GLOBAL SOCIAL UNIVERSALISM
Authors:   Peoples' Friendship University of Russia, EVSTAFYEV D.G.
Published: July 2023

The purpose of the article is to assess the effect of social destruction on key social processes and institutions and to consider the prospects for the structural collapse of the entire system of post-industrial postmodernity. Methodology. The main research method is the method of predictive clustering through the identification of common signs of social context for social processes. This method allows you to highlight the features of mod-ern global transformations, which are determined by a combination of the following elements. Firstly, a critical change in the architecture of global political and economic relations. Secondly, the crisis of the economic de-velopment model built on the dominance of financial capitalism. Thirdly, the slow but consistent destruction of the universalist model of social de-velopment, including its sociocultural component. The latter began with attempts to delineate the contours of the post-human world within the framework of the "Davos Consensus". Where, on the one hand, the pro-spect of human neurofication and the algorithmization of their social be-havior began to be widely discussed, and on the other hand, the concept of the precariat was born. This concept implies the lumpenization of sig-nificant sections of the population of post-industrial postmodern coun-tries including through the socio-political legalization of precarity as a "new social normality". Results: identification of the main "breaking points" in the basic social and socio-political institutions characteristic of the space of post-industrial postmodernity. There is a statement of the high probability of a crisis of the entire system of social universalism of post-industrial postmodernity, and therefore a crisis of Western-centric globalization as a model of development.
TRENDS IN THE DEVELOPMENT OF MODERN COMMUNICATION TECHNOLOGIES IN ORGANIZATIONS IN CONDITIONS OF DIGITALIZATION
Authors:   Central Russian Institute of Management, Branch of RANEPA, LANSKAYA A.V. , SUROVNEVA K.A. ,   Central Russian Institute of Management, Branch of RANEPA
Published: July 2023

In modern conditions, the role of infocommunications has significantly increased, and their widespread use in the socio-economic sphere began to manifest itself most clearly during the coronavirus pandemic, when most companies switched to a remote work format. The purpose of the study is to systematize the distinctive features of modern communications that ensure the effective interaction of institutions and actors in the business environment and to present an assessment of the current state of communication technologies that affect digitalization processes. The article presents the role of communication technologies in providing competitive advantages for enterprises and organizations. The basis of the methodology for writing this article was theoretical and empirical research methods. In the study of the essence of the category "communication", synthesis and analysis of the accumulated scientific results was used, the logical method was applied in the study of trends in the development of communication technologies, and the method of analyzing the results obtained was used in drawing conclusions. As a result, the main factors and barriers that impede the effective implementation of the communication process in organizations in the context of digitalization are identified, and the distinctive features of modern communications due to the development of digital and information technologies are identified. The main stages of the evolutionary development of digital communications associated with the emergence of new and unique technologies for their time are identified. The influence of the technological factor on the emergence of various types of infocommunication technologies are established, the competitive advantages that organizations using infocommunications receive are determined.
Ensayos ecotoxicológicos para evaluar antibióticos y ansiolíticos en el ambiente acuático
Authors: García-Alcalde Malory , Minaya David , Alvariño Lorena , Iannacone José , Rodríguez Amparo
Published: July 2023

Introducción. Los fármacos de uso humano ocasionan daños ambientales y en organismos no destinatarios en el ambiente acuático. Objetivo. Evaluar los efectos toxicológicos de un antibiótico basado en Oxitetraciclina (OX) sobre el camarón salino (Artemia franciscana) y el isópodo marino (Excirolana braziliensis) y los efectos de un ansiolítico, el alprazolam (AL), sobre el anfípodo marino (Apohyalegrandicornis). Materiales y métodos. Los individuos de A. franciscana y E. braziliensis fueron expuestos a OX, y A., grandicornis fue expuesto a AL. Se contabilizó el número de organismos vivos y muertos en cada una de las diluciones a las 24 y 48 h de exposición. Resultados. En A. franciscana se observó que, a 48 h de exposición, la CL50 (concentración letal media) de OX fue 31 % más sensible en comparación a las 24 h de exposición. En E. braziliensis se encontró que, a 48 hde exposición, la CL50 de OX fue 93 % más sensible en comparación a las 24 h de exposición. Se observó en A. grandicornisque, a 48 h de exposición, la CL50 de AL fue69 % más sensible en comparación a las 24h de exposición. La catalogación toxicológica para la OX en A. franciscana consideró a este fármaco como no tóxico y en E. braziliensis moderadamente tóxico. El AL en A., grandicornis fue moderadamente tóxico. Conclusiones. Estos tres bioindicadores permitieron evaluar la toxicidad en el ambiente acuático de productos farmacéuticos de uso intensivo durante el periodo del Covid-19.
Calidad del compost a base de residuos orgánicos urbanos en Leoncio Prado, Perú
Authors: Garrido-Acosta Lorena Raquel , Florida-Rofner Nelino , Nazar- Cipriano Javier , Rengifo-Rojas Alex
Published: July 2023

Introducción. Los residuos sólidos municipales en Perú alcanzaron las 8.215.355,9t en 2021 y solo el 61,28 % fue dispuesto en rellenos sanitarios para ser tratado a través del compostaje, no obstante, la implementación del proceso es deficiente y requiere de estudios para obtener un producto aprovechable como sustrato o enmienda y disminuir la contaminación ambiental. Objetivo. El trabajo determinó los niveles de nutrientes, metales pesados, microorganismos fecales y la calidad del compost a base de residuos sólidos orgánicos urbanos producidas en la planta de valorización Shapajilla, en la provincia Leoncio Prado de Perú. Materiales y métodos. Se sometieron a compostaje cuatro pilas de residuos sólidos orgánicos y se evaluaron nutrientes, metales pesados, microorganismos fecales y calidad en base a la norma chilena2880 y española 824. Resultados. 95 % de los materiales compostados son residuos de comida, frutas y cáscaras, y no presentan diferencias entre pilas evaluadas. Durante el procesamiento la temperatura alcanzó las diferentes etapas y el pH se incrementó. Se encontraron elevados niveles de pH (> 7,50) y bajos en Ca, Mg y K (< 1 %); los metales pesados presentaron diferencias y niveles bajos, con ausencia de microorganismos de origen fecal, y los compost son de calidad intermedia(B). Conclusiones. El compost producido es de calidad intermedia, libre de metales y microorganismos patógenos y puede ser utilizado como sustrato o enmienda con algunas limitaciones por los elevados niveles de pH y los bajos niveles de Ca, Mg y K.
Desarrollo de la economía turística comunal eco-socialismo en el Consejo Comunal la Concepción del “B”
Authors: Mendoza Suarez Jesús Eduardo
Published: July 2023

La presente es una investigación desarrollada en la Universidad Nacional Experimental Simón Rodríguez, núcleo Palo Verde, bajo la modalidad de estudios abiertos o Toparquía, basado principalmente en un modelo empírico-vivencial. Su propósito fue diseñar una propuesta para el desarrollo de la economía turística comunal eco-socialismo, en el Consejo Comunal La Concepción del “B” ubicada en la Parroquia La Vega, Caracas. Se desarrolló primeramente un diagnóstico comunal que permitió identificar las potencialidades y debilidades del sector para poder elaborar la propuesta. La metodología fue cualitativa, con un enfoque hermenéutico- fenomenológico y para la obtención de los datos se empleó la técnica de la observación directa, un estudio de campo, el instrumento aplicado a los informantes claves e integrantes del consejo comunal, fue la entrevista guiada. Se concluyó que los espacios del Parque ecológico Itagua posee gran potencial y variedad de oportunidades para el desarrollo pleno y el fortalecimiento del turismo.
Chlorine dioxide solution in metastatic cancer: case series
Authors: Aparicio-Alonso Manuel , Torres-Solórzano Verónica
Published: July 2023

Chlorine dioxide is a potent oxidant with in vitro anticancer
activity. Its precise mechanism of action has not been thoroughly
explored, but it is proposed that it acts through the redox imbalance of
cancer cells. Three patients were treated for metastatic cancer (kidney,
prostate  and lymphoma), on a compassionate basis. We report lasting
tumor response with a combination of oral, enema and/or intravenous
chlorine dioxide, without side effects. The patients had refused
conventional chemotherapy, radiation therapy or immunotherapy. This
preliminary work suggest that chlorine dioxide and his free radicals
might be the mediators. Chlorine dioxide is both a promising and
unexpensive anticancer agent. Rigorous clinical trials are needed to
confirm these preliminary results.

Keywords: Chlorine dioxide solution, cancer, reactive oxygen
species, intermittent fasting, ketogenic diet
A hydrogen isoscape for tracing the migration of terrestrial herbivorous insects across the Afro-Palearctic range
Authors: Ghouri Sana , Reich Megan S. , Lopez-Mañas Roger , Talavera Gerard , Bowen Gabriel , Vila Roger , Talla Valery N. K. , Collins Steve C. , Martins Dino J. , Bataille Clement
Published: July 2023

Rationale: Many insect species undertake multi-generational migrations
in the Afro-tropical and Palearctic ranges, and understanding their
migratory connectivity remains challenging due to their small size,
short life span and large population sizes. Hydrogen isotope ( δH) can be used to reconstruct the movement of
dispersing or migrating insects, but applying δH for provenance requires a robust isotope baseline
map (i.e., isoscape) for the Afro-Palearctic. Methods: We analysed the
δH in the wings ( δH ) of 142 resident butterflies
from 56 sites across the Afro-Palearctic. The δH values were compared to the
predicted local growing-season precipitation δH values ( δH
) using a linear regression model to develop an
insect wing δH isoscape. We used multivariate
linear mixed models and high-resolution and time-specific remote sensing
climate and environmental data to explore the controls of the residual
δH variability. Results:
A strong linear relationship was found between δH and δH values (r
=0.53). The resulting isoscape showed strong patterns
across the Palearctic but limited variation and high uncertainty for the
Afro-tropics. Positive residuals of this relationship were correlated
with dry conditions for the month preceding sampling whereas negative
residuals were correlated with more wet days for the month preceding
sampling. High intra-site δH
variance was associated with lower relative
humidity for the month preceding sampling and higher elevation.
Conclusion: The δH
isoscape is applicable to trace butterflies, moths and other terrestrial
herbivorous insects that migrate across the Afro-Palearctic range but
has limited geolocation potential in the Afro-tropics. The spatial
analysis of uncertainty using high-resolution climatic data demonstrated
that many African regions with highly variable evaporation rates and
relative humidity have δH
values that are less related to δH values. Increasing geolocation
precision will require new modeling approaches using more time-specific
environmental data and/or independent geolocation tools.
Use of real-world evidence in regulatory decisions for traditional Chinese medicine---Current status and future
Authors: Chen Yuwen , Li Pei , Wang Su
Published: July 2023

Traditional Chinese medicine(TCM) is a valuable resource unique to China
with a long history of human use and clinical practice, which can be
analyzed to generate real-world evidence(RWE). The Chinese government
has been actively promoting regulatory reform that is in line with the
characteristics of TCM, optimizing the clinical evidence system for TCM,
and exploring the important role of RWE in supporting the development of
new drugs and regulatory decision-making for TCM. This article aims to
provide a comprehensive review of the use of RWE in regulatory decisions
for TCM. Based on the characteristics of TCM, this study focuses on the
application scenarios, challenges and opportunities of RWE in TCM. And
some suggestions are put forward to promote the wider application of RWE
in TCM development and supervision.
Qualidade de um estudo de impacto ambiental, por meio da aplicação do método de análise de Lee & Colley
Authors: Campagnaro Virgínia Hamer , Farias Luciana Aparecida , Candiani Giovano
Published: July 2023

Projetos, atividades ou empreendimentos causadores de significativo impacto ambiental, devem ser licenciados por meio da Avaliação de Impacto Ambiental (AIA), a qual encontra-se vinculada à apresentação do Estudo de Impacto Ambiental (EIA). Uma crítica em relação ao EIA têm sido sua baixa qualidade. O objetivo desse trabalho foi avaliar a qualidade de um estudo de impacto ambiental, por meio da aplicação do método de análise de Lee & Colley. A partir da aplicação desse método, foi obtida a nota E para este EIA, caracterizando-o como insatisfatório, possuindo omissões e pontos inadequados significativos. A análise de Lee & Colley apresenta ao todo 73 critérios de análise, incluindo 4 áreas, 17 categorias e 52 subcategorias. Deste total, 73 itens (critérios) analíticos, 24 (cerca de 33%) receberam nota D, 22 (30%) obtiveram nota E e 6 (8%) tiveram nota F. Com isto, 71% dos itens do EIA avaliado foram considerados inadequados. A partir do presente trabalho, foi possível evidenciar que o EIA avaliado não apresenta qualidade satisfatória, dificultando o processo de licenciamento ambiental e a tomada de decisão sobre a viabilidade socioambiental do empreendimento em questão.
Enhanced response of psoriasis to UVB therapy after pretreatment with a lubricating base. A single-blind controlled study.
Authors: Berne B , Blom I , Spångberg S
Published: July 2023

Forty-three out-patients with stable plaque-type psoriasis involving 10-30% of the skin participated in a single-blind controlled study. The psoriasis lesions on one half of the body were treated with a lubricating base of the oil-in-water type before UVB exposure, while those on the other side of the body received UVB only. The rates of improvement of scaling, infiltration and erythema were compared in 127 symmetrical pairs of psoriasis plaques. The scores for the three variables were then summed to yield a total score for the effect of treatment. After only 2 weeks of treatment and throughout the treatment period the rate of improvement in the total score was significantly (p less than 0.001) accelerated on the body half treated with the emollient compared with the control side. Pretreatment with a suitable lubricating base can thus result in shorter treatment periods, which means that the surrounding skin will be exposed to smaller doses of UVB, with a diminished risk of actinic damage.
Skin lesions in renal transplant patients after 10-23 years of immunosuppressive therapy.
Authors: Blohmé I , Larkö O
Published: July 2023

Ninety-eight patients with 10-23 years of uninterrupted immunosuppressive therapy due to renal transplants were investigated for signs of skin disease. Thirty-seven per cent had or had had premalignant or malignant skin lesions. This is significantly different from a control population (p less than 0.0001). There was also a correlation between the length of the immunosuppressive therapy and the risk of acquiring squamous cell skin cancers (p less than 0.05). Fifty-five per cent had common viral warts at the time of the present examination. The duration of immunosuppressive therapy also correlated with the presence of warts (p less than 0.01). Seven patients had mycosis and four patients had seborrheic eczema. In one-third of the patients the skin appeared normal.
Induction of Langerhans' cell mitosis in vivo after orchiectomy on mice.
Authors: Koyama Y , Nagao S , Ohashi K , Takahashi H , Marunouchi T
Published: July 2023

We recently reported that male mice have fewer Langerhans' cells (LCs) than females and that orchiectomy resulted in an increased LC density. In this study we demonstrate that orchiectomy induces a transient increase in the number of paired LCs (PLCs) before the increase in LC density occurs. The results of double staining for adenosine triphosphatase (ATPase) and 5-bromo-2'-deoxyuridine (BrdU) showed that all examined PLCs had incorporated the intraperitoneally injected BrdU, while only 0.7% of the unpaired LCs were BrdU-positive; that supported the notion of PLCs as being divided daughter LCs. Orchiectomy appears to induce a transient increase in mitotic activity of LCs resulting in the increased LC density.
Pemphigus vulgaris associated with pregnancy. A case report from Japan.
Authors: Okano M , Takijiri C , Aoki T , Wada Y , Hayashi A , Fuke Y , Nakayama M
Published: July 2023

We present a case of pemphigus vulgaris which developed during pregnancy. The newborn infant was normal. Bullous lesions were successfully treated by pulse therapy with high-dose corticosteroids. This is, to our knowledge, the first report in English from Japan describing pemphigus vulgaris associated with pregnancy.
Ulceration of the palms and soles. An unusual feature of cutaneous T-cell lymphoma.
Authors: Sheehan-Dare R A , Goodfield M J , Williamson D M , Cotterill J A
Published: July 2023

Two patients, one with Sézary syndrome and one with mycosis fungoides are described, in whom lesions on the palms and soles were associated with extensive ulceration and gave rise to diagnostic difficulty. Extensive ulceration of the palms and soles is uncommon; its presence should alert clinicians to the possibility of cutaneous T-cell lymphoma.
The effects of tetracyclines and erythromycin on complement activation in vitro.
Authors: Ingham E
Published: July 2023

The effects of tetracycline, minocycline and erythromycin on complement activation in vitro were studied. At concentrations of 100 mg/l or less, these antibiotics did not inhibit the capacity of Propionibacterium acnes to cleave C3 in normal human serum or in serum chelated of Ca2+ allowing complement activation by the alternative pathway alone. The antibiotics had no effect (at 100 mg/l) on total haemolytic activity of complement in normal human serum. This study did not provide evidence to support the hypothesis that the efficacy of these antibiotics in the therapy of inflammatory acne vulgaris can be explained by inhibition of complement activation.
Response of atypical bullous pyoderma gangrenosum to oral minocycline hydrochloride and topical steroids.
Authors: Reynolds N J , Peachey R D
Published: July 2023

An 80-year-old Caucasian female with rheumatoid arthritis and recurrent atypical bullous pyoderma gangrenosum is described. There was no evidence of any underlying myeloproliferative disorder. Rapid healing occurred in response to oral minocycline hydrochloride and topical clobetasol propionate.
Immunofluorescent follow-up studies in patients with bullous dermatoses
Authors: Remy W , Bockendahl H , Stüttgen G.
Published: July 2023

Basement zone antibody titres were studied in two patients with bullous pemphigoid over a period of 1-1/2 and 3-1/2 years. Titres remained almost constantly even after a complete healing of all lesions, without any treatment. Direct immunofluorescence revealed basement zone antibodies in one of these two patients when examined after healing had occurred. Three patients with bullous dermatoses showed pemphigus antibodies at the inception of the disease. Basement zone antibodies were present simultaneously in one patient. In the subsequent course of observation in the two other patients, pemphigus antibodies were replaced by basement zone antibodies and in one case by nuclear antibodies too. These findings make the pathogenetic import of these "auto-antibodies" difficult to understand.
Examination of HL-A antigens and lymphocytotoxic antibodies in discoid lupus erythematosus
Authors: Stenszky V , Nagy E , Szerze P.
Published: July 2023

The distribution of HL-A antigens and lymphocytotoxic antibodies has been
Gastrointestinal investigations in dermatitis herpetiformis
Authors: Fausa O , Larsen TE , Husby G , Thune P.
Published: July 2023

Thirty-seven patients with dermatitis herpetiformis (DH) have been investigated for gastric and small intestinal abnormalities. Evidence of an enteropathy was found in 86% of the patients who had IgA deposits in uninvolved skin. Villous atrophy of the small intestine was found in 29 patients. About one-half of the patients had reduced absorption of xylose and vitamin A. The Schilling test value was lowered in one-third. Serum B12 was too low in 5/28 patients whereas folic acid in serum and whole blood was too low in 14/29 and 5/19, respectively. Atrophic gastritis occurred in 14/28 patients and only about one-third of the whole patient material had normal gastric mucosal structure and secretion.
Epidermal surface saccharides reactive with phytohemagglutinins and pemphigus antigen
Authors: Nishikawa T , Harada T , Hatano H , Ogawa H , Miyazaki H.
Published: July 2023

Inorder to study the relationship between epidermal surface saccharides and pemphigus antigen(s), fluorescein-labelled Concanavalin A (Con A) and Phytohemagglutinin-P (PHA-P) were used. These phytohemagglutinins were found to bind with the intercellular areas of human epidermis. Alpha-methyl-D-mannoside and alpha-methyl-D-glucoside inhibited the epidermal intercellular staining pattern produced by ConA-FITC, while N-acetyl-D-galactosamine blocked the same staining pattern produced by PHA-P-FITC. Normal human skin reacted with pemphigus antibody and pemphigus skin with the deposition of IgG both gave a positive intercellular staining pattern with fluorescein labelled phytohemagglutinins. Our data indicated the non-identity of the binding of Con A and PHA-P, and pemphigus antigen(s).
The pigmentation of chronic renal failure
Authors: Comaish JS , Ashcroft T , Kerr DNS
Published: July 2023

Clinical and photometric observations have been made on the hyperpigmented skin of 31 patients in chronic renal failure and in control subjects. Histochemical examination or skin biopsies indicates that the increased pigment observed clinically may not be melanin. A carotenoid or lipochrome substance could be involved.
Immunofluorescence studies in herpes gestationis
Authors: Kocsis M , Eeg TL , Husby G , Rajka G.
Published: July 2023

In 4 cases of H.G., direct junctional immunofluorescence findings showed an intense band of C3 present in the involved skin of the patients even after the active lesions had disappeard (i.e. 2 months later). Weak specific fluorescence for IgG and in one case also for IgA and IgM was seen in the involved skin. A less intense junctional band of C3 was also present in the uninvolved skin. Antibodies against basal membrane have not been detected in the sera of the patients.
Electron microscopic study of nevic corpuscle
Authors: Niizuma K.
Published: July 2023

An intradermal nevus, in which a number of nevic corpuscles were clearly observed, was studied, using the electron microscope. Nevic corpuscles contained laminated cells consisting of flattened cytoplasmic processes stretching across the corpuscles to form a complicated labyrinth. The perikaryon of these cells contained premelonosome-like dense bodies and other organelles including mitochondria, rough-surfaced endoplasmic reticulum, free ribosomes, and Golgi apparatus. Neither axons nor dendrites were found in these areas. From these observations, it was concluded that the nevic corpuscles were composed exclusively of nevus cells and could be clearly distinguished from Meissner corpuscles. This view would support the idea of a unitary origin of nevus cells. In addition, an isolated cilium found in a laminated cell is briefly discribed.
Liver biopsy in methotrexate-treated psoriatics-a re-evalution
Authors: Zachariae H , Grunnet E , Sogaard H.
Published: July 2023

Two-hundred and eighty-six liver biopsies were performed in 139 psoriatics on treatment or considered for treatment with methotrexate. In 56 psoriatics included in this study both pre- and post-methotrexate biopsies were performed, the average methotrexate dose being 936 mg. None of the data showed statistically significant differences between pre- and post-methotrexate biopsies, with the exception of an increase in fattly infiltration, found when comparing all pre-methotrexate biopsies with the total number of latest post-methotrexate samples. As expected, alcohol seemed to be significantly associated with liver fibrosis in pre-methotrexate biopsies. An patients, although potassium arsenite alone has not been proved to be the cause of liver damage among psoriatics included in this study. While only 1 of 22 psoriatics with a total normal biopsy had been on arsenite, 6 of 18 of the same group of psoriatics who had fibrosis had been on this drug earlier. Although no statistically significant differences related to fibrosis and cirrhosis could that in three cases liver cirrhosis did appear in a biopsy from a methotrexate-treated psoriatic who had signs of fibrosis of cirrhosis in a pre-methotrexate biopsy. This incidence is low in relation to the total number of patients treated. The relatively low incidence of cirrhosis found in the present study, as in earlier studies by our group is believed to be due to the use of an intermittent dosage schedule. The study showed that early fibrosis and cirrhosis seem to appear, with very minor abnormalities in laboratory results. This finding indicates the necessity of performing liver biopsies in the control of psoriatics on long-term methotrexate therapy. The difference between biopsies from psoriatics and liver biopsies from control patients may indicate that severity of disease may be a complicating factor in the pathogenesis of the liver damage.
The effects of X-ray, ultraviolet and infrared irradiation on the basement membrane zone antibody reaction of the human skin in vitro
Authors: Remy W , Bockendahl H , Stüttgen G.
Published: July 2023

Two patients with bullous pemphigoid were treated with radio cobalt or betatron irradiation. Thereafter bullous eruptions developed in the non-irradiated skin. It is known from the literature that ultraviolet light applied to the normal-appearing skin of patients with bullous pemphigoid produced fresh histologic and immunohistochemical changes in the irradiated skin. X-ray irradiation applied to human skin biopsy specimens using single doses of 7 000 and 8 000 R resulted in an increase of basement membrane zone antibody binding of 2-3 titre dilution steps. An increase of 3-4 titre dilution steps was achieved by irradiation with ultraviolet light. Infrared irradiation of skin biopsy specimens, on the contrary, caused the total loss of the basement membrane zone fluorescence. It merits further study, whether these contrary effects on the basement membrane zone antibody binding of human skin in vitro (activation of bound antigen after X-ray or ultraviolet irradiation and inactivation of antigen caused by infrared irradiation) are of clinical value concerning the bullous pemphigoid problem in vivo.
Urinary excretion of 5-S-cysteinyldopa in patients with primary melanoma or melanoma metastasis
Authors: Agrup G , Agrup P , Andersson T , Falck B , Hansson J-A , Jacobsson S , Rorsman H , Rosengrem A-M , Rosengren E.
Published: July 2023

Urinary excretion of 5-S-cysteinyldopa was studied in 9 patients with primary melanoma. All had 5-S-cysteinyldopa excretion in the normal range. In 8 of the patients excretion values decreased after removal of the tumour. Twenty-four
Abnormal cutaneous reactions in dermatitis herpetiformis
Authors: Michaëlsson G , Svensson L.
Published: July 2023

In 94% of the patients with dermatitis herpetiformis, a locally applied ointment with an ester of nicotinic acid (Trafuril) induced an abnormal reaction with erythema, edema, papules, and often vesicles. The appearance of the reaction to Trafuril is similar to DH lesions. It differs markedly from the reactions to iodide where, as a rule, only one large blister results. The reaction is most pronounced 12-24 hours after application of Trafuril. The reactivity is strongest in the predilection areas for dermatitis herpetiformis. Strongly increased reactivity to Trafuril in DH is induced by pretreatment with streptokinase, streptokinase-streptodornase, or urokinase. Diminished reactivity to Trafuril is seen after pretreatment with injections of Compound 48/80, tranexamic acid, cromoglycate, or application of fluocinolone-acetonide, as well as after stroking the skin.
Pachyonychia congenita. A clinical, histological and microradiographic study with special reference to oral manifestations
Authors: Anneroth G , Isacsson G , Lagerholm B , Lindvall A-M , Thyresson N.
Published: July 2023

This paper rresents a clinical, histological and microradiographic study of three patients with pachyonychia congenita with special reference to oral manifestations. The patients, who are relatives, exhibited thickening of finger- and toe-nails, follicular keratosis, palmoplantar keratosis and hyperhidrosis, oral leukokeratosis, and natal teeth. It is stated in the discussion that natal teeth and oral leukokeratosis may constitute the earliest clinical manifestations of pachyonychia congenita and that they appear to accur earlier than nail lesions. When there is a hereditary disposition for pachyonychia congenita, it is important to inspect the oral cavity at an early stage.
Electron microscopic and cytochemical observations of mast cells containing melanosomes in blue nevus
Authors: Sato S , Kukita A.
Published: July 2023

Abstract is not availeble.
Chromosome aberrations in affected and unaffected skin of patients with psoriasis
Authors: Petersen GB , Christiansen JV , Voetmann E , Therkelsen AJ.
Published: July 2023

Abstract is not availeble.
Pustulosis palmaris et plantaris treated with hydroxyurea
Authors: Hattel T , Sondergaard J.
Published: July 2023

Abstract is not availeble.
Immunoglobulins in atopic dermatitis with special reference to IgE
Authors: Ohman S , Johansson SG.
Published: July 2023

Abstract is not availeble.
Pigment diposits in eyes and light-exposed skin during long-term methacycline therapy
Authors: Dyster-Aas K , Hansson H , Miörner G , Möller H , Rausing A.
Published: July 2023

Abstract is not availeble.
Embryology of the epidermis: ultrastructural aspects. III. Maturation and primary appearance of dendritic cells in the mouse with mammalian comparisons
Authors: Weiss LW , Zelickson AS.
Published: July 2023

The epidermis of mice ranging in age from prenatal day 17 through postnatal day 4 and, in addition, postnatal day 18, was studied with the electron microscope. In the 17 day fetus, the periderm may or may not be present and a stratum corneum is developing in the latter case. The cells of the strata spinosum and granulosum contain much glycogen and many keratinosomes and homogeneous keratohyalin granules which appear to line up in a row near the distal cell membranes, fuse and form keratinized cells which contain material similar in density to that of the individual keratohyalin granules. In the 18 to 20 day fetuses, no periderm is present. The stratum corneum becomes well-developed. The quantity of glycogen decreases but the number of keratinosomes and keratohyalin granules increases. Some cells in the basal region contain necrotic phagocytosed cells. Few changes occur in the epidermis of the neonate, although the stratum corneum increases in thickness. In the early postnatal period, the mouse epidermis is mature in appearance and resembles that of man. By postnatal day 18, the whole epidermis is much thinner, although all classical strata can usually be identified. The primary appearance and subsequent maturation of epidermal dendritic cells was also studied in the mouse during the embryonic, fetal, early postnatal and 18 day postnatal periods. Melanocytes which lacked cell processes were first identified in the 15 day fetus. Melanocyte cell processes and an increasing number of melanosomes, as well as melanocytes, are present between prenatal day 18 and postnatal day 3. On postnatal day 4, fewer melanocytes are present and they contain vacuoles. Phagocytosed melanocytes are also present within basal keratinocytes. Undifferentiated dendritic cells or indeterminate cells are observed beginning on prenatal day 16. These cells do not appear to increase significantly in number subsequently. On postnatal day 18, Langerhans cells and indeterminate cells are present but no melanocytes can be identified. No Merkel cells were observed. Mitotic dendritic cells or dendritic cells traversing the basal lamina were not observed.
Drug-induced lupus erythematosus syndrome. Immuno-pathological, electronmicroscopical and serological studies
Authors: Ullman S , Wiik A , Kobayasi T , Halberg P.
Published: July 2023

Abstract is not availeble.
Erythrohepatic protoporphyria and its treatment with beta-carotene
Authors: Krook G , Haeger-Aronsen B.
Published: July 2023

Abstract is not availeble.
Simulataneous occurrence of Neisseria gonorrhoeae, Candida albicans, and Trichomonas vaginalis
Authors: Nielsen R , Sondergaard J , Ullman S.
Published: July 2023

Abstract is not availeble.
An improved method for the preparation of epidermal sheets
Authors: Schellander FG , Sinclair M.
Published: July 2023

Abstract is not availeble.
Correlative study of rubella antibody titre, basement zone antibody titre, and IgG content of sera of patients with bullous pemphigoid
Authors: Remy W , Bockendahl H , Antoniadis G.
Published: July 2023

Abstract is not availeble.
Iron metabolism in tetracycline-treated acne patients
Authors: Hägermark O , Höglund S.
Published: July 2023

Abstract is not availeble.
Hematological changes in psoriasis. Secondary anemia, XVIII
Authors: Molin L , Reizenstein P.
Published: July 2023

Abstract is not availeble.
Occupational and non-occupational scrotal cancer in Sweden, 1958-1970
Authors: Wahlberg JE.
Published: July 2023

Abstract is not availeble.
On the occurrence of genital herpes simplex virus infection. Clinical and virological findings and relation to gonorrhoea
Authors: Jeansson S , Molin L.
Published: July 2023

Abstract is not availeble.
Treatment of generalized scleroderma with inhibitors of connective tissue formation
Authors: Asboe-Hansen G.
Published: July 2023

103 patients suffering from generalized scleroderma were studied in order to assess the effect of treatment with inhibitors of connective tissue formation. 93 patients with generalized scleroderma were given D-penicillamine, benzyl-penicillin-diethylamino-ethyl-ester hydroiodide, adrenal glucocorticoids, dextro-thyroxine, hydralazine, and "mixed treatment" (one or several of the drugs in consecutive courses, or concurrently). The effect of dextrothyroxine could not be evaluated in this study. No improvement could be seen after adrenocortical steroid therapy. Hydralazine seemed to be effective. D-penicillamine improved 25 of 34 treated patients; penicillin hydroiodide 12 out of 16. The dermal sclerosis of 6 patients regressed completely; in 16, sclerosis regressed with the exception of finger sclerosis; in 32, partial regression was registered; 20 had their progression arrested, but there was no regression; in 19 cases, there was no effect whatsoever. The prognosis seemed to be better for young than for old people. The age at onset was lower in the better groups. The higher the total dose, the better the results. The length of the treatment course is probably of some significance. The short-lasting cases had better prospects than the longer lasting. Ten untreated patients of this material and 11 patients seen earlier showed continued progression. Side effects leading to discontinuation of the drugs were seen in a substantial number of patients, especially after D-penicillamine. Twelve deaths could not be related to the treatments.
Implantation dermatoses
Authors: Mehregan AH , Faghri B.
Published: July 2023

Abstract is not availeble.
T- and B-cells and IgE in mycosis fungoides
Authors: Zachariae H , Ellegaard J , Grunnet E , Søgaard H , Thulin H.
Published: July 2023

The role of T- and B-lymphocytes and serum IgE was studied in 22 patients with
Acquired (digital) fibrokeratomas. Complication of ingrown toenail
Authors: Herman PS , Datnow B.
Published: July 2023

Abstract is not availeble.
Attempts to induce sensitization in guinea pigs with nickel complexes
Authors: Samitz MH , Katz SA , Scheiner DM , Lewis JE.
Published: July 2023

A technique for the induction of sensitization in pigs with a nickel-alanine conjugate has been reported by other investigators. Similar results were observed in our experiments in mini-pigs. However, using the identical technique, we were unable to induce sensitization in guinea pigs with NiSO4, with nickel-alanine or other nickel-amino acid complexes, or with a complex of nickel with soluble guinea pig skin extract. These results indicate that nickel-amino acid complexes and nickel-guinea pig skin complex were not antigenic in guinea pigs with this technique. Hypotheses for the apparent failure to induce sensitization are proposed.
Generalized plane xanthomas and monoclonal IgG
Authors: Hammar H.
Published: July 2023

Abstract is not availeble.
Periodic acid methenamine silver (pam) staining of the human subcutaneous lymphatic vessel
Authors: Okuma M.
Published: July 2023

The fine structure of the subcutaneous lymphatic vessel taken from the dorsum pedis of the human adult was investigated without and after impregnation by periodic acid methenamine silver (PAM). To check the stainability of another tissue, the renal glomerulus of the rat was also examined in the same way as outlined above. The membrane system of various cells stains positive. No special surface coat of the endothelial cell of the lymphatic vessel was detected. The fine intracellular filament as well as a continuous basal lamina of the endothelial cell were almost PAM-negative, although a part of the basal lamina was occasionally weakly positive. The chemical composition of the basal lamina of the lymphatic vessel is considered to differ from that of the glomerular blood capillary of the kidney, which is PAM-positive. This difference is thought to be due to the smaller polysaccharide content in the former than in the latter.
Werner's syndrome and malignancy
Authors: Björnberg A.
Published: July 2023

Ten per cent of all patients with Werner's syndrome develop some form of malignant disease, half of them sarcomas. A case of Werner's syndrome is reported in which the patient had a malignant fibroxanthoma of the thigh followed by a papillary cystadenocarcinoma of the ovaries. A brother with clinical signs of Werner's syndrome died of acute leukaemia.
Bullous pyoderma gangrenosum in association with myeloid leukaemia
Authors: Cramers M.
Published: July 2023

The case is presented of a patient with busulfan (Myleran) treated myeloid leukaemia, who developed bullous pyoderma gangrenosum. Skin symptoms appeared at the time when treatment was discontinued due to signs of bone marrow depression. The pyoderma disappeared following treatment with systemic steroid.
Clinical and histopathological studies on spotted grouped pigmented nevi with special reference to eccrine-centered nevus
Authors: Morishima T , Endo M , Imagawa I , Morioka S.
Published: July 2023

Clinical and histopathological studies on 16 cases of spotted grouped pigmented nevus resulted in this disease being classified into at least three types. Characteristic findings of each type are described in this paper, in particular that nevus cell proliferation, a finding common to each type, is closely related pathogenetically to skin appendages, especially with eccrine sweat ducts. The eccrine-centered nevus characterized by Mishima corresponds to the third type, according to the present author's classification. The similar characteristic histopathological finding was also observed in a specimen taken from a black papule in a case of giant pigmented nevus with disseminated pigment cell nevi. We would like to consider that the cells of eccrine-centered nevus are derived from nevoblasts present in the walls of sweat ducts.
Identification of mononuclear cells infiltrating basal cell carcinomas
Authors: Claudy AL , Viac J , Schmitt D , Alario A , Thivolet J.
Published: July 2023

The identification of mononuclear cells extracted from 12 basal cell carcinomas has been carried out by means of various assays such as the E rosette test, FITC anti-Ig conjugates and peroxidase conjugates viewed at an ultrastructural level. The relative quantities of B and T cells have been determined as well as the morphology of the extracted cells. It was found that the T/B ratio is close to that of a delayed-type reaction to tuberculin, suggesting a possible identical immune mechanism, and also that the morphological appearance of some tissue lymphocytes differs from that of circulating lymphocytes due to the presence of both membrane and cytoplasmic Ig.
Metastasizing erythroplasia Queyrat. Report of a case
Authors: Avrach WW , Christensen HE.
Published: July 2023

A typical clinical and histologic case of Queyrat's erythroplasia of the glans penis is presented. For several years the patient had been treated for balanitis and inflammation of the glans. A few months before the patient died, the correct diagnosis was established. Shortly after, metastases to the inguinal lymph nodes were found and treated with X-rays. At autopsy, metastases to other organs were revealed. It is concluded that erythroplasia of Queyrat might be Bowen's disease of a mucosal or mucocutaneous area, and this "carcinoma in situ" may metastasize. Consequently Queyrat's erythroplasia should be treated as a malignant disorder as soon as the diagnosis is established.
Friction blisters as a manifestation of pathomimia
Authors: Brehmer-Andersson E , Göransson K.
Published: July 2023

Self-inflicted skin lesions (pathomimia, artefacts) can be produced in a variety of ways, by the help of nails, razor blades, cigarettes, chemicals, etc. The present study reports three cases of pathomimia, in which the lesions consisted of vesicles or bullae producted by friction. Friction blisters can easily be produced in sites where the epidermis is both thick and firmly attached to the underlying tissues. The blisters have a characteristic histological appearance, which makes it possible to distinguish them from the blisters of different forms of vesicular and bullous diseases and from burn blisters which may also occur in pathomimia.
Lichen planus and acne provoked by gold
Authors: Hjortshoj A.
Published: July 2023

A 58-year-old man with rheumatoid arthritis developed lichen planus during treatment with gold. Four months after cessation of treatment, a severe acne with comedones, papules, pustules, and small cystic elements broke out. No connection could be demonstrated between the eruption and other drugs or chemicals. Acne provoked by gold seems not to have been described elsewhere. The case history confirms that gold treatment, even in the same patient, can give rise to a wide range of skin disturbances, which in many cases do not break out until long after the drug has been withdrawn.
Methotrexate therapy for psoriasis in elderly patients with impaired renal function
Authors: Weismann K.
Published: July 2023

Abstract is not available
Ulstrastructural study of leukodermic skin in Waardenburg-Klein syndrome
Authors: Perrot H , Ortonne JP , Thivolet J.
Published: July 2023

The skin of a patient with Waardenburg syndrome has been studied by electron microscope. In leukodermic skin, there were neither melanocytes nor indeterminate cells; Langerhans cells were normal in number and distribution. On the edge of the lesion, melanocytes were few and appeared degenerated, with abnormal melanosomes; indeterminate cells were observed in suprabasal areas. Healthy skin also showed melanosome abnormalities. These findings are discussed and compared with the characteristics of piebaldism.
Increased succinate dehydrogenase activity of lymphocytes in eczema
Authors: Shelley WB , Comaish JS.
Published: July 2023

Succinate dehydrogenase activity has been studied in the peripheral blood lymphocytes from controls and patients with a variety of skin and other diseases. Increased activity has been found in eczematous dermatitis and dermographism, and also in one patient with chronic lymphatic leukemia. Normal levels were found in psoriasis. The enzyme activity is broadly correlated with the extent and activity of the disease process.
An in vitro study of depressed cell-mediated immunity and of T and B lymphocytes in atopic dermatitis
Authors: Hovmark A.
Published: July 2023

Lymphocyte transformation tests, E binding(T) rosette assay and immunofluorescent preparations of B cells were studied in patients with atopic dermatitis, and also in healthy controls. Most of the patients were found to have high levels of IgE in serum. The patients were studied both during severe bouts of dermatitis and also when the dermatitis was almost healed. Lymphocyte transformation tests showed that patients were hyporeactive to PPD and herpes simplex antigen in vitro, both during periods of severe dermatitis and also when the dermatitis was in remission. The response to PHA in the patients was normal in vitro. No factors which could reduce cell-mediated immunity in vitro were found in patients' sera. A decreased number of T lymphocytes and a slight increase in the number of immunoglobulin-bearing lymphocytes (B cells) were demonstrated in the patients, both during remission and during recurrence of severe dermatitis. In 3 of 8 patients, increased numbers of IgE-bearing lymphocytes were found to be present when the patients had severe dermatitis. A possible correlation between high serum levels of IgE and depressed cell-mediated immunity in patients with atopic dermatitis is discussed.