bluuebunny/crossref_metadata_2025 huggingface dataset:
Incidence of Dermatitis Herpetiformis in Sweden 2005 to 2018: A Nationwide Retrospective Cohort Study
Authors: Albadri Zeyad , Al Bayati Doua , Häbel Henrike , Jerkovic Gulin Sandra , Grönhagen Carina , Seifert Oliver
Published: November 2023

Dermatitis herpetiformis has been investigated in the past; however, only a limited number of studies have reported its incidence based on validated nationwide population-based registries. To address this gap, the aims of this study are to estimate the incidence of dermatitis herpetiformis in Sweden and to validate the National Patient Register (NPR) for diagnosis of dermatitis herpetiformis. A population-based open cohort study was conducted, including all patients diagnosed with dermatitis herpetiformis (International Classification of Diseases 10th revision; ICD-10 code L13.0) in Sweden from 2005 to 2018 (n = 1,724), identified from the NPR. The diagnosis of dermatitis herpetiformis in the NPR was validated using medical records, histopathological and immunopathological data, yielding a positive predictive value (PPV) of 62.5%. The mean annual incidence of dermatitis herpetiformis was 0.93/100,000 (95% confidence interval 0.79–1.08), female to male ratio 1:1, and mean age at diagnosis 60.9 years. In conclusion, this large nationwide cohort study showed a low validity for diagnosis of dermatitis herpetiformis in the NPR, and the adjusted incidence rate of dermatitis herpetiformis in Sweden was estimated to be 0.93/100,000, which is lower than that in previous Swedish studies.
Design and numerical assessment of an additively manufactured Schwarz diamond triply periodic minimal surface fluid-fluid heat exchanger
Authors: Röver Tim , Kuehne Maxim , Bischop Floyd , Clague Leighton , Bossen Bastian , Emmelmann Claus
Published: November 2023

In aerospace, thermal applications demand compact, lightweight, and efficient heat exchangers. Additive manufacturing processes offer the potential to create highly complex structures that are not achievable through traditional manufacturing methods. This work presents the development of an additively manufactured fluid-fluid heat exchanger that shows the potential to enhance the performance, reduce weight, and increase compactness compared to a conventional plate heat exchanger. A numerical model of the conventional plate heat exchanger was created, and fluid dynamics simulations with heat transfer were performed. Validation of the simulations was done by experiments. Then, a novel heat exchanger was designed using a bottom-up approach and investigated at different levels of complexity using computational fluid dynamics. The internal structure of the final heat exchanger consists of a repeating triply periodic Schwarz diamond minimum surface elongated in the direction of flow. The heat exchanger was manufactured with laser powder bed fusion process using AlSi10Mg. It had a 108% higher compactness and 54% lower weight compared to the plate heat exchanger. Numerical analysis yielded the pressure loss in pascal was reduced by 50%–59% while heat transfer in watts was improved by 3%–5%. Future researches should experimentally investigate the thermal and fluid mechanical characteristics of the novel additively manufactured heat exchanger and increase compactness and heat transfer further by analyzing the minimum partition wall thickness and the impact of wall roughness and deposit formation.
POETICAL ANALYSIS OF THE IMAGE OF UKRAINE IN O. DOVZHENKO'S FILM STORY “UKRAINE ON FIRE”
Authors: Panchenko Olena , Bilous Karolina
Published: November 2023

The appearance of the central image of Ukraine in the film story “Ukraine on fire” as the dominant character of insubordination and the tragedy of the suffering of the Ukrainian people. The image of Ukraine in O. Dovzhenko's film story “Ukraine on Fire” is an undisguised, tragic truth about the fate of the Ukrainian people during the Great Patriotic War. The years 1941–1942 remained in history as the most difficult hours of the great grief of the war for Ukraine. This is the time when all of Ukraine was occupied by fascists. Oleksandr Dovzhenko watched all these bloody events, it was the war that served as a prerequisite for writing a film story. In these dire and terrible times for Ukrainians, the author admitted that he created it “with fiery pain in his heart and burning suffering for Ukraine, which was in German hands, with painful regret and fear for its fate” (Dovzhenko, 1956: 102). Such methods as hermenevtic interpretation, descriptional, structural are used. The purpose is to discover deep meanings, carved in this film story, due to which stylistic devices author emphasizes the horror of the war.
THE PROBLEM OF OVERCOMING LANGUAGE BARRIERS BY STUDENTS OF NON-LINGUISTIC SPECIALTIES
Authors: Ryzhenko Maryna , Anisenko Olena
Published: November 2023

The article presents studies of barriers to learning a foreign language and possible ways to overcome them. The relevance of the problem is proven by the analysis of modern processes of globalization and their influence on the demands placed on future specialists. An analysis of psychological-pedagogical and scientific-methodical literary sources of domestic and foreign authors, who studied various aspects of the emergence and overcoming of foreign-language barriers in the educational process of modern higher education institutions, was carried out. The purpose of the article is to analyze the barriers that arise when learning a foreign language and to determine ways to overcome them in the conditions of modern institutions of higher education. The content of the concept of psychological barrier in the context of learning a foreign language is specified. Having considered the available definitions of barriers in learning a foreign language, the authors state that the barrier in foreign language communication is an internal obstacle of a psychological nature that prevents the successful implementation of a certain activity. The article is devoted to the problem of overcoming language barriers by students of non-linguistic specialties when learning foreign languages. It is emphasized that the elimination of language barriers is the main a condition for optimizing the teaching of foreign languages in a technical university. The main causes of communication failures. Recommendations are given for organizing the educational process in foreign languages taking into account the language barrier factor.
THE THIRD WORLD CONGRESS OF FREE UKRAINIANS AS A COMPONENT OF STRUGGLE FOR THE RIGHTS OF THE UKRAINIAN NATION
Authors: Vakhnyanyn Anna
Published: November 2023

The article examines the preparation and proceedings of the Third World Congress of Free Ukrainians (WCFU). The author highlights the key challenges faced by the organizers of this event, including a lack of funds and a decline in interest. Furthermore, the article analyzes the influence of international factors on the activities of the WCFU, particularly the processes of decolonization and the increased focus on human rights and freedoms in the 1970s. As a result of these developments, representatives of the Ukrainian, Belarusian, Estonian, Latvian and Lithuanian World Congresses jointly drafted a “Memorandum on Decolonization of the USSR” and submitted it for consideration by the United Nations (UN). To conclude the Congress, a demonstration titled “Defending the Rights of Ukraine – For the Decolonization of the USSR” was organized. The article highlights key achievements of the Commission on Human Rights of the WCFU, including the defense of the rights of political prisoners such as Valentyn Moroz, Leonid Plyushch, Mykola Rudenko, Oleksiy Tykhyi, Lev Lukianenko and others. The Commission also participated in conferences under the auspices of the UN in honor of the International Women's Year in Mexico in 1975 and Habitat Conference in Vancouver in 1976. Moreover, the article examines the reaction of the Soviet press to the Third WCFU and identifies the main clichés of Soviet propaganda used to describe this event.
IMPACT OF STRESS FACTORS ON UKRAINIAN WAR VICTIMS IN THE COUNTRY AND ABROAD
Authors: Kolesnikova Olena , Radchenko Anastasiia , Zaprovalna Olga , Emelyanova Nataliya , Strashnenko Hanna
Published: November 2023

The purpose of the study was to estimate the frequency of the most probable stress factors and behavioural disorders based on the our own survey results among Ukrainians in accordance with the place of residence. The study was conducted from January to August 2023 and included 160 participants, divided into 3 groups: 1 group – those who remained in their hometown (n=80), 2 – internally displaced people (n=49), 3 – participants, living abroad (n=31). A deterioration in the quality of sleep and nutrition was often found among patients in group 2 and 3, common stress factors in these groups included loss or change of job and low socialization. In group 1, sleep disturbances were caused by traumatic experience, changes in work and its conditions affected the frequency of smoking, alcohol abuse and the quality of nutrition. In order to reduce the severity or eliminate behavioural risk factors, special attention should be paid to overcoming the consequences of traumatic experiences among people who remain in their hometown, to integrating internally displaced persons into society, and to immediate providing psychological support to people living abroad.
The Role of Physiotherapy in Parity-Induced Flatus Incontinence: A Case Report
Authors: Goodness Mba Chidinma
Published: November 2023

Gas incontinence also known as Flatus incontinence is a common postpartum anal incontinence which impairs social participation and also lacks established protocol of management. Symptom persistency has been reported after perineal muscles repair due to weakness/ loss in function of the pelvic floor muscles. This case report describes about the importance and effectiveness of Pelvic Floor Muscle Rehabilitation (PMR) in a 28year old primiparous woman, four months postpartum who presented with parity-induced flatus incontinence aggravated after sexual activities at a the Physiotherapy clinic of a state government owned hospital located in the south eastern part of Nigeria. Pelvic Muscle Rehabilitation (PMR) and Stabilization exercises were administered thirty minutes (30mins) to forty-five minutes (45mins) three times (3x), a week (1 week) for four weeks (4weeks). There was a significant reduction in Mark’s (Vaizey) score by more than 2 points at the end of the four weeks of physiotherapy intervention and also patient recorded improvement in all the domains of faecal incontinence quality of life scale, pelvic floor muscle strength (anal squeeze pressure) and pelvic floor muscle function (endurance and coordination).
Effectiveness of Ultrasound-Guided Dry Needling In Painful Musculoskeletal Conditions: A Systematic Review and Meta-Analysis
Authors: KKL Reeves
Published: November 2023

Objective: To identify the treatment effects of pain and disability in US-guided DN on various painful musculoskeletal conditions. Methods: A comprehensive literature search of six databases without language restrictions was conducted for relevant articles containing quantitative data. Randomized controlled trials (RCTs) or quasi-experimental studies involving the effectiveness of US-guided DN on pain and disability in adult patients (age >18 years) with painful musculoskeletal conditions were included. Studies that not related to US-guided DN, paediatric patients, and patients with acute, trauma, postoperative, or malignant pain were excluded. The quality and certainty of the included articles were assessed using the PEDro scale and the GRADE approach respectively. Results: Four high-quality studies with a total of 240 patients’ data, aged 18-71 years old, were included in this meta-analysis. Results showed a significant improvement in pain with US-guided DN (p<0.001) with a standardized mean difference of 0.96 (95% CI: 0.66, 1.27; I2=31.23). On the other hand, a significant improvement in disability is seen with US-guided DN (p<0.001) with a standardized mean difference of 0.85 (95% CI: 0.61, 1.09; I2=30.89). Both outcomes had symmetric funnel plots, and the results of Egger’s test showed no significant publication bias. Conclusion: US-guided DN is a safe and effective treatment modality for reducing pain and disability for some painful musculoskeletal conditions in the short-term. However, only limited high-quality study examined the effectiveness of USguided DN over various painful musculoskeletal conditions. Further high-quality studies that focus on the long-term treatment effects of US-guided DN on various painful musculoskeletal conditions are warranted. Impact statement: Our systematic review suggested that ultrasound guided dry needling has short-term effects for those painful musculoskeletal conditions which led 2 out of 10 people to seek medical care annually in reducing pain and disability
Mucoepidermoid Carcinoma of the Thyroid Gland with Lymphovascular Invasion: A Case Report
Authors: AA Mohamed
Published: November 2023

Mucoepidermoid carcinomas (MECs) are generally found in salivary glands, but they have also been mentioned in other organs such as the larynx, esophagus, and breast. Mucoepidermoid carcinoma (MEC) of the thyroid is a very rare and lowgrade indolent neoplasm. In past reports of the thyroid MEC, only nine cases were described as poor prognosis. We here present a case of a female patient, 29 years old, euthyroid, no chronic medical illness, no drug history, non-smoker; she is married and has 3 children. She presented to the hospital with painless neck swelling. Fine needle aspiration cytology (FNAC) showed mixture of squamoid cells and pale enlarged cells with cytoplasmic vacuoles and devoid of colloid with possible pseudo inclusions. (Consistent with Hűrthle cell neoplasm). Lt hemithyroidectomy was done and sent to histopathology for diagnosis. Histopathology analysis revealed a microscopic focus of intrathyroidal intermediate-grade MEC within the Lt lobe nodule. The patient was scheduled for completion thyroidectomy with midline cervical lymphadenectomy after metastatic work-up was done. The present case is a rare presentation of intermediate-grade thyroidal MEC
Nuevos registros de trucha arco iris Oncorhynchus mykiss (Walbaum, 1792) del Noroeste argentino y barreras naturales que limitan su dispersión
Authors: Contrera Maria Guadalupe , Fernández Luis
Published: November 2023

Oncorhynchus mykiss es una especie exótica invasora ampliamente distribuida en la cordillera andina. La trucha arco iris es reportada para dos arroyos endorreicos del oeste de la provincia de Catamarca entre los 3.200 y 3.600 m s.n.m. Tanto Catamarca (34 especies y 5 exóticas) como La Rioja (14 especies y 4 exóticas) presentan muy baja diversidad de especies nativos y se encuentran severamente amenazados por la dispersión accidental o intencional de la trucha arco iris. Los resultados mostraron que la presencia de barreras naturales (por ejemplo, cascadas, profundidad y química del agua) podrían ser los principales factores determinantes para la distribución de la trucha arco iris en los arroyos de la región Puna.
Comparación de indicadores de la desertificación en la Región Pampeana y en la frontera de expansión agropecuaria en la República Argentina
Authors: Civeira Gabriela , Rodriguez Beatriz
Published: November 2023

El proceso de desertificación se está generalizando en la Argentina. En la Región Pampeana y Extra Pampeana, la generalización del monocultivo de soja y el manejo no sustentable han aumentado el proceso de desertificación. Los indicadores biofísicos del suelo permiten evaluar la fragilidad del sistema productivo y la salud edáfica. El objetivo de este trabajo fue: recopilar y sistematizar indicadores biofísicos de la desertificación en el área actual y de avance de la frontera agropecuaria, evaluando su capacidad de monitoreo de la degradación de suelos. El análisis recopiló y sistematizó información primaria y secundaria proveniente de trabajos de investigación, publicaciones y boletines, entre otros. Se evaluaron para la Región Pampeana y Extra Pampeana indicadores biofísicos: carbono orgánico total (COT), contenido de nitrógeno total (N total), fósforo extractable (P Bray) y densidad aparente (DAP). Se recopilaron rendimientos de los cultivos de trigo y soja. El COT influyó positivamente sobre el rendimiento en la Región Pampeana. Los suelos de la Región Extra Pampeana presentaron valores inferiores de N total y P Bray en comparación a la Región Pampeana. La Región Pampeana presentó una relación positiva significativa entre COT y DAP (p<0.05; R²=0,335). En la Región Extra Pampeana, la DAP no influenció los rendimientos como en la Región Pampeana. Los rendimientos extra pampeanos podrían estar condicionados por las condiciones climáticas. En ambas regiones, los indicadores describieron el impacto de la actividad agrícola en las propiedades edáficas en las últimas décadas. Los indicadores sensibles al uso agrícola predecirían procesos de degradación, previniendo consecuencias irreversibles en el uso del suelo a futuro.
Preventing Disruptive Behavior in Elementary School Students: An Academic Investigation from a Multicultural Islamic Education Lens
Authors: Khoirotun Ulfun , El yunusi Muhammad Yusron Maulana
Published: November 2023

The objective of this study is to identify strategies for enhancing the social development of children within inclusive educational settings. The present study employs a qualitative research design and adopts a phenomenological framework. The study was conducted in SD Muhammadiyah 3, Ikrom Wage Sidoarjo, with a sample size of five individuals who were chosen as participants. The data collection process involved the utilisation of in-depth interviews and observation techniques, which were subsequently followed by data reduction and data display procedures. Subsequently, the data underwent analysis by the method of triangulation. The present study yielded the subsequent findings: The term "character" refers to the attributes, traits, and qualities that define an individual's personality and behaviour. It encompasses a The social attributes of pupils at SD Muhammadiyah 3 Ikrom were enhanced, encompassing virtues such as honesty, civility, social responsibility, tolerance, democracy, and justice. The process of enhancing character development is implemented for all students, especially those who possess exceptional requirements. The implementation of multicultural education is accomplished through two primary methods: firstly, by incorporating it into the curriculum across many disciplines taught in the classroom, and secondly, by fostering a school environment that embraces and upholds the principles and values of multicultural education. The process of integrating subjects is facilitated with the active participation of educators who have received specialised training. Educators receive periodic training sessions focused on strategies and approaches for instructing students with exceptionalities. In the context of educational institutions, the process of school acculturation is often implemented during the initial orientation phase for incoming students. During student orientation, it is crucial to prioritise the instruction of habits and fostering a sense of acceptance towards individuals with diverse backgrounds.
Relationship between Death Anxiety and Suicide Potential in An Adolescent Population
Authors: D'Atttlio John P. , Campbell Brian
Published: November 2023

The relationship between death anxiety and suicide potential was examined in a sample of 62 male and female adolescents whose ages ranged from 16 to 20 yr. A Pearson product-moment correlation between scores on Templer's Death Anxiety Scale and Cull and Gill's Suicide Probability Scale was significant for death anxiety and suicide potential, with higher death anxiety associated with greater suicidal risk. The implications of this association with respect to adolescent suicidal behaviors is discussed.
Key factors influencing the national security concept of the People's Republic of China
Authors: MALANICHEVA Natal'ya V. , KHARINA Ol'ga A. , BALAKHANOVA Dariko K. , FILIN Sergei A. , GENKIN Evgenii V.
Published: November 2023

Subject. This article considers the national security ensuring as a condition for successful economic development.
Objectives. The article aims to analyze the mechanisms for protecting China's national interests in the context of the aggravation of the international situation and the slowdown in economic growth.
Methods. For the study, we used the methods of comparative and structural analyses.
Results. The article notes that China is currently implementing a policy of ensuring comprehensive security and paying special attention to preserving the country's territorial integrity, resolving territorial disputes, ensuring access to natural resources, protecting intellectual property, and preventing threats associated with the development of information technology.
Conclusions. Despite complicated relationships with Japan, India, and the United States, armed conflicts involving China are unlikely in the near future.
Developing a region's economic security mechanism
Authors: GRADOBOEV Evgenii V.
Published: November 2023

Subject. This article discusses the role of healthcare in ensuring economic security.
Objectives. The article aims to develop a model for assessing the level of economic security in the region, taking into account the costs of providing medical care in various conditions.
Methods. For the study, I used a simulation approach based on the concept of mechanism design and game theory.
Results. The article finds the dependence between the content of the development strategies of medical organizations and the level of economic security of the region. The article presents a developed mathematical model that helps predict the level of economic security in the region and determine priorities in financing the healthcare system.
Conclusions. The article concludes that the probability of bankruptcy of private medical organizations is quite high, since the strategies chosen by them lead to the need to attract funding from extra-budgetary sources for all conditions of medical care.
Identification of region's industry growth zones
Authors: ZAZIRNYI Ivan D.
Published: November 2023

Subject. This article examines the innovative potential of the regions of Russia and the problems of balanced development of the country's regions.
Objectives. The article aims to form a set of indicators, the consideration of which can help determine the potential of the region's economic sectors.
Methods. For the study, I used the general scientific research methods.
Results. Based on the analysis of various approaches to the definition of the concept of Growth Zone, the article finds that the accuracy of determining growth zones increases when industries are decomposed into sub-industries. When determining the zones of growth, it is necessary to take into account the economic, innovative, social, and spatial factors of the region's development.
Conclusions. The results of the study can be taken into account when developing strategies for the socio-economic development of regions and determining areas of specialization.
Factors for the impact investing implementation: Assessing the macroregion's social environment development indicators
Authors: KVON Gul'nara M.
Published: November 2023

Subject. This article analyzes the differentiation of the Ural regions in terms of investment potential.
Objectives. The article aims to rank the Ural regions to optimize the investment policy.
Methods. For the study, I used a comparative analysis.
Results. Based on the analysis of various factors of economic development, the article finds that in the Ural macroregion, the best conditions for the implementation of impact investing technologies have developed in the Sverdlovsk Oblast, and the worst ones appear to be in the Kurgan Oblast. The article offers the author-developed algorithm for assessing the investment potential of the region.
Relevance. The proposed algorithm for assessing the investment potential of the region can be used to design economic development programmes for the medium term.
Aktualisierungstendenz oder Interaktion zuerst?
Authors: Klein Margot , Le Coutre Christine , Galliker Mark
Published: November 2023

In der vorliegenden Arbeit wird nach Gemeinsamkeiten und Unterschieden in den Stellungnahmen zum dialogischen Selbst gesucht. Während Staemmler von einer starken Relationalität ausgeht, nach der die menschliche Psyche soziokulturell konstituiert wird, gehen seiner Meinung nach personzentrierte Autoren eher von einer abgeschwächten Relationalität aus, bei der neben dem intrapersonalen auch das interpersonale Geschehen berücksichtigt wird. Entscheidend ist, dass im Personzentrierten Ansatz und insbesondere bei Gendlin Aktualisierungstendenz und Interaktion schließlich zu einer Einheit finden und sich „das Selbst“ als Objekt auf löst. Am Ende des Artikels wird auf die Bedeutung der Kontroverse für die psychotherapeutische Praxis hingewiesen.
PSICOLOGIA ORGANIZACIONAL: UMA ANÁLISE CORRELACIONAL ENTRE A CULTURA ORGANIZACIONAL E A AUTOEFICÁCIA
Authors: Villalba Alexandre da Silva , De Oliveira Villela Alessandra Ramos , Duarte Cleia
Published: November 2023

O presente estudo analisou a correlação entre a cultura organizacional e a autoeficácia organizacional. Objetivou entender a formação da cultura organizacional e investigar a influência mútuo entre os dois construtos com base no pressuposto de que a cultura organizacional influencia de modo significativo a autoeficácia de funcionários. Trata-se de uma pesquisa transversal com tratamento quantitativo, alcance explicativo, correlacional. A amostra foi composta por cem funcionários distribuídos aleatoriamente entre os sexos considerando dados sociodemográficos como a idade e o salário. Para captação de dados utilizou-se o Instrumento Brasileiro de Avaliação da Cultura Organizacional (IBACO) e a Escala de Autoeficácia Geral Percebida (EAGP). Considerou-se o coeficiente de correlação de Pearson apresentando correlação positiva entre cultura organizacional e autoeficácia p=0,88. Em relação à faixa etária, os mais novos apresentaram forte correlação p=0,95 e os mais velhos baixa correlação p=0,15. Quanto ao sexo, as mulheres apresentaram forte correlação p=0,81 em comparação com os homens.
The Weakness of Iraqi Islamic High Schools Students During Reading Comprehension Activities in English , the Reasons and Remedies , Intermediate Grade as a Model
Authors: Jasim Al Zubaidi Nihad Mohammed
Published: November 2023

This study aims at figuring out The weakness of Islamic High Schools Students in Iraq during reading comprehension activities in English as a foreign language, The Reasons and Remedies, intermediate stage as a model”. The study examines the effect of teachers' variables (gender, qualification, and years of experience), In order to achieve the objectives of the study, the researcher developed a data collection instrument: a questionnaire developed in English for the teachers. It consisted of two parts. The first one is demographic questions and the second consisted from 14 questions. The researcher conducted this study on the intermediate stage students who are learning English as a foreign language and their teachers of English of Islamic High School in Iraq by using a stratified random sample. The whole population consisted of (140) teachers, (68) males and (72) females. The results of the present study showed that reading difficulties faced by students in learning English resulting from students' reading behaviors were high. In addition, the content (textbook), teaching aids and teaching methods had a significant effect on the reading difficulties. In the light of the findings of the study, the researcher recommended holding training courses for the teachers to provide them with sufficient experience to teach their students the reading skill in the right way besides Attention distraction, lack of motivation, difficulty in academic content, feeling of making mistakes in front of colleagues, lack of a library concerned in English language in the school and lack of resources in the English language, insufficient time to read during the lesson , their speed of reading is very slow, their efficiency in understanding the meaning of a text is very poor and there are other reasons mentioned in this study. .
Students with Reading Disorders: Their Characteristics and Affected Skill Areas
Authors: Abdulla Barazanja Kazhaw Jafar , Ameen Wirya Ahmed
Published: November 2023

Some children appear to grow normally until they face the academic demands of school. These learners cannot make their way continue compensating for the added content-learning demands. Their performance problems are sometimes rooted in reading disorders. Reading disorder is a specific learning disability described by disorders with correct and /or fluent word recognition, and poor spelling and decoding abilities. This study aims to highlight the characteristic features of reading disorder and the skill area affected by students suffering from reading so that they can be used as a basis for identifying this disorder among learners. The study concludes that the main characteristics of reading disorder could be found in the following areas 'reading, writing and the general aspect of learner's life'. Besides, the skill area affected by students with a reading disorder is realized by a deficit in the main components of being a good reader, that is: (reading decoding, word recognition, reading fluency, and reading comprehension). A deficit in one of these components could result in a reading disability by learners.
Sex Determination and Foramen Magnum Measurement (CT Study Case in Sulaimani Population)
Authors: Mustafa haji Karem Shara , Qadir Mahmood Salah , Mahmood Talabani Ranjdar , A. Abas Layla , H. Azeez Shoxan , Mohammed Sha Aram
Published: November 2023

Foramen magnum that is positioned under the sagittal suture and surrounded by the lateral, squamous, and basilar parts of the occipital bone is one of the most important structures in the base of the skull. Genetic, socioeconomic, and environmental factors have a significant impact on sexual dimorphism in FM dimensions which is population-specific. The present retrospective study was carried out in Sulaimani teaching hospital, Sulaimani, Iraq. The study sample consisted of 100 adult patients including 50 females and 50 males aged 20-70 years. All of the patients had CT scanned for their necks and heads over the period June 2017 to March 2019. In order to examine the foramen magnum, its sagittal diameter, transverse diameter, area, index, and circumference were measured. Student’s t-test and histogram were used to analyze the data, and Receiver Operating Characteristic (ROC) curve and Binary Logistic Regression model were employed to obtain a model for sex determination. We found that women had a lower average value than men in our study. According to the independent t-test results; the genders were significantly different in terms of all measured parameters (p<0.05). As demonstrated by the ROC curve, the predictability of the dimensions in sexing the crania for sagittal diameter, transverse diameter, and area of foramen was respectively 76.0%, 66.0%, and 74.0%. The current study indicated a high percentage of sex predictability regarding the dimensions, areas, and circumference, which is because of the highly significant difference between the genders.
Genesis of equifinality and multifinality of open systems
Authors: Gribkov Andrei Armovich
Published: November 2023

The subject of research in the article are the properties of equifinality and multifinality of open systems, widely spread in all subject areas, at all levels of organization: in physical, chemical, biological, economic, social, etc. open systems. Equifinality is a dynamic property of a system that realizes movement (transition) in different ways from different initial states to the same final state. Multifinality is the dynamic property of a system to reach fundamentally different final states under insignificant changes in initial conditions. Examples of realization of the properties of equifinality and multifinality in systems of different nature: physical, biological, economic are considered. The genesis of these properties is investigated. On the basis of the study of the genesis of the properties of equifinality and multifinality its commonality is revealed: both properties are a consequence of the transformation of quasi-continuous quantitative changes into discrete qualitative forms, as well as the limited variety of these forms caused by isomorphism. The origin of the multiplicativity property (increased sensitivity to variation of input parameters) and its difference from multifinality are revealed. The multiplicativity property is manifested in systems with unequal stability, including those possessing positive feedback mechanisms. In some systems, such as meteorological mathematical models, the properties of multiplicativity and multifinality appear simultaneously and cannot be unambiguously distinguished.
Evaluation of the effectiveness of training and the use of neural networks to predict biological age.
Authors: Berezina Tatiana Nikolaevna , Balan Aleksandr , Zimina Al'bina Aleksandrovna
Published: November 2023

Neural network training is widely used in various educational fields: staff training, mastering the curriculum at school and university, forming recommendations for private use by respondents, for teaching pensioners health-saving techniques. It is relevant to analyze the learning process of neural networks and evaluate their effectiveness on various models. For the study, a model was chosen for predicting the index of biological aging of a person based on the characteristics of his personality. To train neural networks, a data matrix of 1,632 people aged 35 to 70 years was compiled. Output variable: biological aging index; input variables: gender, age, family and professional status, place of residence, body type, type of functional asymmetry, style of relationships with people, as well as personal resources. Four neural networks were trained: for men and women, for working professionals and for pensioners. Results: 1) trained neural networks give different recommendations for men and women of pre-retirement and post-retirement age. 2) The effectiveness of predicting the biological aging index using neural networks turned out to be significantly high for all trained programs. 3) Neural networks can be used to model various social situations and identify what changes this will lead to for output variables. Situations were modeled: a) if all single adults get married, b) if all family adults break up, c) if everyone receives the recommendations of psychologists on the selection of personal resources and will use them. The neural network has issued a forecast: it is better for adult women not to change their family status/it is better for adult men to change their status. The use of personal resources selected by psychologists is effective for everyone.
OFICINA DE EFEITOS VISUAIS COM ESTUDANTES DA EDUCAÇÃO DE JOVENS E ADULTOS: RELATO DE EXPERIÊNCIA
Authors: Pedro Elvira dos Santos Barbosa São , Nuñez Dora Arguello
Published: November 2023

Em uma perspectiva interdisciplinar evolvendo as disciplinas Língua Portuguesa, Redação, História, Dança, Música e Artes Visuais, desenvolvemos a Oficina de Efeitos Visuais: Zumbi dos Palmares não morreu, seus ideais étnicos, de liberdade, de uma sociedade livre do preconceito perduram até hoje. Baseado nestas ideias, em uma turma de educação de jovens e adultos, (EJA) desenvolvemos a referida oficina com foco em destacar a importância da cultura africana e a valorização do negro na sociedade. Ao concluí-lo percebemos como resultados que os estudantes compreenderam a importância de reconhecer a ancestralidade e a cultura negra na nossa sociedade e a elevação de sua autoestima o que culminou com a apresentação da oficina, projeto e gravação do programa Viver a Escola da TV Educativa, do IRDEB Bahia.
Search for predictors of psoriatic arthritis in patients with psoriasis
Authors: Artamonova Olga G. , Karamova Arfenya E. , Kubanov Alexey A. , Verbenko Dmitry A. , Kozlova Irina V.
Published: November 2023

Background. Psoriatic arthritis is a chronic inflammatory disease of the joints, spine and entheses that can occur in patients with psoriasis. The prevalence of psoriatic arthritis is 19.7%. In 70% of cases, psoriasis precedes the development of arthritis. It has been proven that a delay in the diagnosis of psoriatic arthritis even by 6 months is associated with a deterioration in long-term radiological and functional results, leading to disability. The problem of early diagnosis of joint damage can be solved by identifying predictors of the risk of developing psoriatic arthritis in patients with psoriasis.
Aims. To determine possible predictors for the development of psoriatic arthritis in patients with psoriasis.
Methods. The open, uncontrolled, prospective study enrolled 250 patients. The main group consisted of 190 patients diagnosed with plaque psoriasis. The control group consisted of 60 patients with psoriatic arthritis. In order to identify associations of clinical and genetic (HLA-B27 carriage) parameters with the development of psoriatic arthritis, we compared the frequency of occurrence of these parameters in patients with psoriatic arthritis and without.
Results. Among 190 patients with plaque psoriasis 128 (67.4%) men, 62 (32.6%) women, aged 18 to 84 years (40.30 ± 15.56), the average duration of psoriasis was 10.09 ± 11.08 years (0–57). Among 60 patients with psoriatic arthritis 39 (65%) men, 21 (35%) women aged 18 to 86 years (44.43 ± 14.15), the average duration of psoriasis was 20.47 ± 13.22 years (2–57), the average duration of psoriatic arthritis was 7.97 ± 9.95 years (0–47). Сlinical predictors for the development of psoriatic arthritis in patients with psoriasis: nail psoriasis (OR = 2.244 [95% CI: 1.245–4.045]); severe psoriasis (PASI ≥ 20) (OR = 2.148 [95% CI: 1.161–3.975]); arterial hypertension (OR = 1.982 [95% CI: 1.031–3.812]); duration of psoriasis over 25 years (OR = 3.365 [95% CI: 1.676–6.756]), р 0,05.
Conclusions. The joint consideration of informative predictors will allow us to develop an original multi-parameter mathematical model for calculating the risk of developing psoriatic arthritis in patients with psoriasis.
Narrow-band UVB phototherapy in patients with atopic dermatitis: analysis of the factors determining treatment efficacy
Authors: Chikin Vadim V. , Karamova Arfenya E. , Kubanov Alexey A. , Zhilova Maryanna B. , Gorodnichev Pavel V. , Aulova Kseniya M.
Published: November 2023

Background. Efficacy the narrow-band UVB phototherapy in patients with atopic dermatitis varies greatly. An important condition for achieving optimal therapeutic effect is the identification of factors that can impact on the efficacy of therapy and considering their influence when prescribing treatment.
Aims. The present study aimed to identify the factors which affect the efficacy of narrow-band phototherapy in patients with atopic dermatitis
Methods. A prospective, open-label trial was conducted to evaluate the efficacy and safety of narrow-band UVB phototherapy for patients with moderate-to-severe atopic dermatitis. All patients were treated with narrow-band UVB phototherapy four times weekly for 5 weeks. Disease severity was evaluated by SCORing of the Atopic Dermatitis Index (SCORAD) and Eczema Area and Severity Index (EASI). Distribution of patients by the severity of therapeutic effect was evaluated. To compare the efficacy of therapy depending on initial atopic dermatitis severity, initial and cumulative irradiation doses, skin phototype, and smoking status patients were divided into subgroups.
Results. 40 patients with moderate-to-severe atopic dermatitis received course of narrow-band UVB phototherapy. After NB-UVB therapy SCORAD and EASI scores reduced from 45.6 ± 11.4 at baseline to 22.6 ± 12.4 (p 0,05) and from 14.4 ± 7.2 at baseline to 4.1 ± 3.9 (p 0,05) respectively demonstrating the efficacy of narrow-band UVB phototherapy in patients with atopic dermatitis. Our investigation showed that tobacco smokers had definitely lower efficacy of NB-UVB phototherapy in comparison with non-smokers. Narrow-band UVB phototherapy had definitely higher efficacy when it is started with an initial dose 0.2–0.3 J/cm2 chosen in compliance with results of MED determing in comparison with an initial dose 0.05–0.15 J/cm2 selected according to skin phototype.
Conclusions. Factors that impact on the efficacy of narrow-band UVB phototherapy in patients with atopic dermatitis were identified. It was determined that using higher initial dose is associated with higher efficacy of therapy. The obtained data suggest the opportunity of decrease in efficacy of therapy in smokers with atopic dermatitis.
Avaliação do perfil e do impacto na formação de estudantes voluntários participantes da extensão universitária em um cursinho popular
Authors: Vieira Lucas , Rosa Lauren Waiss da , Ribeiro Inauã Weirich , Seganfredo Mariana Kaefer , Trindade Fernanda Rocha da
Published: November 2023

Objetivo: Analisar o perfil e o impacto na formação dos voluntários que participam de um cursinho popular em uma universidade comunitária do interior do Rio Grande do Sul. Métodos: Constituiu em aplicação de um questionário online para os voluntários, abrangendo temas como a satisfação com o projeto, recursos humanos e materiais disponíveis, espaço físico e infraestrutura, coordenação e organização, resultados obtidos e participação dos voluntários. Resultados: Dos 63 voluntários convidados, 17 responderam completamente o questionário. A análise de perfil demonstrou que a maioria dos voluntários é solteiro e tem entre 20 e 30 anos de idade. Embora a maioria dos voluntários tenha menos de seis meses de experiência no projeto, 09 têm mais de dois anos de voluntariado. Os principais resultados indicam que a maioria dos voluntários se sente satisfeito com o projeto, especialmente com a interação, relacionamento com outros voluntários e com a acolhida no início do projeto. No entanto, há aspectos a serem melhorados em termos de recursos e materiais disponíveis, coordenação e organização do projeto. Conclusão: Evidencia-se que o cursinho popular é um projeto importante para a formação dos estudantes envolvidos como voluntários, contribuindo para a transformação social da comunidade.
Stem cells: Current applications and future prospects
Authors: Gupta Dhanvin Richie , Singh Sakshya
Published: November 2023

Stem cells are non-specialized cells that can differentiate into many kinds of cells. They have been an important part of research since their discovery due to their immense potential for treating many incurable diseases through various kinds of related therapies or procedures. Stem cell technology and research are developing rapidly every year. This paper summarizes the latest developments in stem cell research while also commenting about its future potential and the ethical concerns related to it.
Photobiocatalytic CO2 Reduction into CO by Organic Nanoparticle-Carbon Monoxide Dehydrogenase Assemblies: Surfactant Matters
Authors: Pavliuk Mariia V. , Böhm Maximilian , Wilhelmsen Janna , Land Henrik , Tian Haining
Published: November 2023

CO2 reduction through semiartificial photosynthesis represents an attractive approach for conversion of solar light and abundant resources to value-added chemicals. Herein, designing highly efficient biocompatible photocatalysts that can boost CO2 reduction by the enzyme is desirable. In this work, biohybrid assemblies composed of a phenoxazine-based organic molecule (POZ-M) nanoparticular photosensitizer decorated with various surfactants and coupled with the nickel containing carbon monoxide dehydrogenase II from Carboxydothermus hydrogenoformans (CODH) are investigated. Organic nanoparticles that are decorated with CO2-responsive surfactant are capable of interaction with all components in the photocatalytic system. They increase the local CO2 concentration around the enzyme which renders a superior CO production rate of 1140 µmol g-1 h-1 that is two orders of magnitude higher than that for organic nanoparticles covered with PS-PEG-COOH surfactant.
A Cobalt Molecular Catalyst for Hydrogen Evolution Reaction with Record Activity in Phosphate Buffered Water Solution
Authors: Trotta Caterina , Dahiya Pardeep , Baldinelli Lorenzo , Menendez Rodriguez Gabriel , Chakraborty Priyanka , Bistoni Giovanni , De Angelis Filippo , Sundararaju Basker , Macchioni Alceo
Published: November 2023

Herein, we show that [Cp*Co(2-ampy)I]I (2-ampy = 2-aminomethyl-pyridine) is an extremely active catalyst for HER, exhib- iting a record TOF of 109000 s-1 in phosphate buffered water solution (pH 7). The key to this remarkable activity stems from the establishment of a network of weak interactions in the second coordination sphere. As a matter of fact, both experimental and theoretical studies strongly suggest that the –NH2 functionality of 2-ampy ligand acts as an anchoring and orienting group for H2PO4- through the establishment of an in- termolecular hydrogen bonding with it that, in turn, intermolecularly donates a proton to Co–H liberating H2.
Charge Transfer Mechanism in Guanine-based Self-Assembled Monolayers on a Gold Surface
Authors: Lucia-Tamudo Jesús , Nogueira Juan Jose , Díaz-Tendero Sergio
Published: November 2023

In this work, we have theoretically determined the one-electron oxidation potentials and charge transfer mechanisms in complex systems based on a self-assembled monolayer of guanine molecules adsorbed on a gold surface through different organic linkers. Simulations were carried out in the framework of the Marcus theory and in combination with an additive scheme previously developed. The conformational sampling, description of the environment and effects caused by the linker have been considered. We unravel the phenomena of electric current transport by evaluating the different stages in which charge transfer could occur. The results revealed that the positive charge migrates from the organic layer to the gold surface through a single ligand and driven with the help of the electrostatic interactions of the surrounding molecules. The established computational protocol sheds light on the mechanism behind charge transport in electrochemical DNA-based biosensor nanodevices.
Progress Towards the Total Synthesis of Nogalamycin using a Benzyne Cycloaddition Strategy
Authors: Dequina Hillary , Vine Logan , Schomaker Jennifer
Published: November 2023

Nogalamycin (NOG) is a member of the anthracycline glycoside natural products; no total syntheses have yet been reported and there is minimal understanding of how the aglycone substitution pattern and the identities of the A- and D-ring sugar impact anticancer activity and toxicity. This paper reports progress towards a modular approach to NOG that could enable systematic structure-activity relationship studies. Key steps include a regioselective benzyne cycloaddition and a reductive ring-opening to assemble a versatile AB core for analogue synthesis.
The tautomer-specific excited state dynamics of 2,6-diaminopurine using REMPI and quantum chemical calculations
Authors: Gate Gregory , Williams Ann , Boldissar Samuel , Sponer Jiri , Szabla Rafał , de Vries Mattanjah
Published: November 2023

2,6-diaminopurine (2,6-dAP) is an alternative nucleobase that potentially played a role in prebiotic chemistry. We studied its excited state dynamics in the gas phase by REMPI, IR-UV hole burning, and ps pump-probe spectroscopy and performed quantum chemical calculations at the SCS-ADC(2) level of theory to interpret the experimental results. We found the 9H tautomer to have a small barrier to ultrafast relaxation via puckering of its 6-membered ring. The 7H tautomer has a larger barrier to reach a conical intersection and also has a sizable triplet yield. These results are discussed relative to other purines, for which 9H tautomerization appears to be more photostable than 7H and homosubstituted purines appear to be less photostable than heterosubstituted or singly substituted purines.