bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Paradox of Psychoanalytic Thinking
Authors: Irimia Daniela
Published: March 2022

Psychoanalytic thinking was born in the psychoanalytic relationship and its biography begins in the first persson plural, us. Maybe this plural, me and my patient, is at first only in the mind of the therapist clearly stated. My patient and I are concerned from the beginning to find together those mental, emotional connections that will open the way for the therapeutic process. We are, as Donnel Stern says, partners in thought, a paradoxical thought, which feeds and creates from the intimate substance of our encounter, in the cabinet, but also in the mind of each of us, in which we receive the Other, in all the metamorphosis of transference.

Probably the most difficult thing in this adventure is to succeed in creating a relational field, often implicit, in which it is possible to meet deeply the two lives and histories of ours, from which then is born the narrow edge of therapeutic intimacy that Ehrenberg so beautifully and honestly uncovered in her book.
The Model of Trauma, According to Ferenczi - without Sympathy There Is No Healing or Feeling Together with
Authors: Romaneț Gabriela
Published: March 2022

Using the notes of Ferenczi throughout the Clinical Diary, I recomposed his work with patient B., through which, together with patient R.N., Ferenczi came to encounter the psychogenesis of trauma and mental shock, urging him to develop a theory and a technique of working with trauma, constantly seeking healing and treatment. Based on this clinical excerpt, I discuss about trauma, approached theoretically and technically, emphasizing both the importance of knowing the mechanisms of trauma and the importance of healing, through communication from affect to affect, which allows a chance for rearrangement.
TRIGGERED FACTORS OF GRINGSING TENGANAN DOUBLE IKAT COMMODIFICATION IN THE GLOBALIZATION ERA
Authors: Sri Sukmadewi Ida Ayu Kade , Anom Kumbara A.A. Ngurah , Suarka I Nyoman , Wiasti Ni Made
Published: March 2022

The double woven cloth of Gringsing, Tenganan, Karangasem Bali serves as a ritual medium in traditional, religious, marriage activities, is sacred, and weaving skills are inherited from generation to generation (habitus) from their ancestors. Globalization and the entry of the tourism industry have influenced the development of the Gringsing double ikat fabric. Development is carried out by commodifying form and meaning, so as to create products with new meanings. The purpose of this study is to identify and understand the factors that cause the commodification of double ikat fabrics in Gringsing Tenganan, Karangasem in the era of globalization. This study used descriptive qualitative method. The techniques used in data collection, namely observation techniques, in-depth interview techniques, and document studies. The collected data were analyzed using analytical techniques, verified (data display), and concluded in narratives, tables, photos, and charts. The theory used in this research is the commodification theory of Barker and Piliang. The results of the study, namely the commodification of double ikat fabrics in Gringsing Tenganan, Karangasem in the era of globalization occurred due to internal and external factors. Internal factors that support the commodification of the Gringsing double ikat fabric are the economic orientation of the Tenganan community, the orientation of equality and freedom of life as well as ideology and outlook on life. External factors such as globalization and tourism development in Tenganan Pagringsingan Village, Karangasem.

Keywords: commodification, gringsing double ikat, globalization
Adaptasi dan properti psikometri Parental Stress Scale versi Bahasa Indonesia
Authors: Kumalasari Dewi , Gani Izmiyah Afaf Abdul , Fourianalistyawati Endang
Published: March 2022

Stres pengasuhan adalah ketegangan yang dialami orang tua terkait peran pengasuhan. Parental Stress Scale (PSS) merupakan instrumen yang telah banyak digunakan untuk mengukur stres pengasuhan yang dialami orang tua. Sejumlah studi di beberapa negara telah berusaha mengungkap validitas konstruk dan reliabilitas dari PSS. Penelitian ini bertujuan untuk menguji properti psikometri Skala Stres Pengasuhan (SSP) yang merupakan adaptasi PSS dengan mengombinasikan pendekatan Analisis Faktor Eksploratori (EFA) dan Analisis Faktor Konfirmatori (CFA). Penelitian ini melibatkan 449 orang tua, khususnya ibu di Indonesia yang memiliki anak berusia 3-12 tahun. Sampel dalam penelitian ini dibagi menjadi dua kelompok sampel secara acak, di mana analisis EFA dilakukan pada kelompok sampel pertama (N = 249) dan analisis CFA dilakukan pada kelompok sampel kedua (N = 200). Hasil analisis statistik menunjukkan struktur dua dimensi dari 15 butir SSP memiliki properti psikometri yang memuaskan.
Corporate Social Responsibility and the National Culture in Automotive Dealerships
Authors: Schefer Roveda Taisa , Baccin Brizolla Maria Margarete , Dias Lopes Luis Felipe
Published: March 2022

Objective: this study seeks to analyze the relationships between dimensions of national culture and corporate social responsibility (CSR) practices in automotive dealerships.
Theoretical framework: the theoretical bases used correspond to the contents of CSR and Hofstede’s cultural dimensions.
Method: a survey-type quantitative study design was employed and classified as field research; 108 questionnaires were applied, and 43 were answered by managers and 65 by employees of seven organizations in Rio Grande do Sul State. The answers were validated using structural equations.
Results and conclusion: our findings showed a positive relationship between long-term orientation and CSR practices; a negative relationship between masculinity, power distance, and uncertainty avoidance and CSR practices was also observed. Hence, the dimension of national culture, long-term orientation, and uncertainty avoidance were positively associated with CSR practices.
Research implications: the implication is in implementing CSR practices and their relationship with the cultural dimensions, seeking to encourage management procedures in automotive dealerships, serving as support for decision making. Thus, this study contributes to expanding knowledge about the subject studied.
Originality/value: The study’s originality lies in analyzing the relationships between the dimensions of national culture and CSR practices in automotive dealerships. Furthermore, it provides subsidies for understanding how organizations behave from changes in the environment and understanding concepts about ethics and corporate responsibility involving CSR practices and national culture.
TRADITIONAL MIDWIFERY IN TURKEY, GERMANY & GREECE
Authors:   Kayseri Provincial HealthDirectorate. Kayseri /Turkey, Güden Emel
Published: March 2022

Purpose: The development process of midwifery in Turkey, Germany and Greece has followed different paths exactly the same way these three countries differ in history and culture. However,the needs of pregnant women are universal, and traditional midwives in all above-mentioned countries have acted accordingly. The aim of this study is to go down the history path and trace the evolutionary process which took midwifery from the traditional phase of being community members supporting the birthing women to modern midwifery education. The study refers to the three countries Turkey, Germany and Greece. Materials and Methods: A literature review was conducted on the traditional midwifery, midwifery history and development of midwifery education system of all three countries by the team of authors as part of an Erasmus+ Project[2018-1-TR01-KA202-059488].The information contained in books, scientific articles, internet library, historical archives and grey literature was included in the research.References in German, English, Greek and Turkish were included in the scope review. The collected data were converted into a standard shape format and converted into text.The findings obtained from this study are also presented in the published project result report (https://projectfirsttouch.blogspot.com). Findings:Traditional midwifery has been a transfer of knowledge and skills from mother to daughter. Along with rituals influenced by religion, mostly herbal incense, tea and oils have been used in all three countries as auxiliary methods of supporting pregnancy and childbirth.The maternity chair is an auxiliary tool with traditional use in all three countries.There are very few studies in the literature on the scientific effects of traditional methods. Conclusion: As with traditional methods of treatment, there should be evidence-based methods to help childbirth, and there should be methods that will not endanger the health of the mother and baby.More work is needed on this issue.
Occasional Diagnosis of Acute Myeloid Leukemia Due To SARS-COV 2 Infection Diagnóstico ocasional de leucemia mielóide aguda em vigência de infecção por SARS-CoV-2
Authors: Ribeiro Leonardo , Pereira João Pedro , Melo Carine Emanuele , Lopes Claudia Regina , Alves Juliana , Guzzi Gustavo , Pinto Marcelo , Moura Mariely
Published: March 2022

OBJECTIVES: To describe a patient with SARS-CoV-2, who was diagnosed with acute myeloid leukemia M3. CASE REPORT: Patient, 12 years old, female, started with bruises in the lower limbs and pain in the left leg; however, in the face of the current pandemic, the patient was delayed in seeking medical help due to fear of contamination by SARS-CoV-2. After 1 month she presented fever, runny nose, and cacosmia. She sought medical assistance for apprehension of being infected with the new coronavirus due to the fact that the mother is a health professional. The child was admitted to the emergency room, with leukopenia, thrombocy-topenia, and positive COVID-19. She remained hospitalized for 8 days in the hospital of entry. Initially, it was suspected of idiopathic thrombocytopenic purpura; however, with the evolution of the case it suggested the diagnostic possibility of oncological disease. She was transferred to a specialty hospital, where she was diagnosed with acute myeloid leukemia subtype M3. After diagnosis, tretinoin associated with platelet transfusion and cryoprecipitate and subsequent chemotherapy with idarubicin was started. CONCLUSIONS: It can be analyzed that, in the face of the SARS-CoV-2 pandemic, many diseases can arise together with the viral infectious condition. On the other hand, we cannot fail to consider that in view of the current epidemiological and behavioral changes, the diagnosis, treatment, and prognosis of previously existing diseases that, in due course, coexist with SARS-CoV-2 infection, can be postponed, due to the fear and due to the difficulty of accessing the health system.
Front Matter
Authors: Jurnal Riset Kimia Editor in Chief
Published: March 2022

Front Matter
Espacios urbanos de desplazamiento en ciudades brasileñas denominadas Patrimonio Cultural de la Humanidad por la UNESCO bajo el concepto de destino turístico inteligente
Authors:   Universidade Federal do Maranhão (Brasil), Santos Saulo Ribeiro dos
Published: March 2022

The objective set is to analyze the comments of TripAdvisor users regarding urban travel spaces in the destinations of the cultural heritage of humanity in Brazil, under the bias of the concept of smart tour‑ ist destination. The methodological design is characterized by bibliographic, documentary, exploratory and descriptive research. All the online comments of five Brazilian cities on TripAdvisor were analyzed qualita‑ tively between the months of January to July 2017. The results show that users highlight aspects related to urban and tourist infrastructure, which are fundamental precepts for becoming a destination. smart tourist. In this way, public management, as responsible for the execution of public policies and tourist plans, must act directly in the improvement of the infrastructure of the historical heritage, allowing the tourist destina‑ tion to adapt to the concept of universal access
Recursos naturais e histórico-culturais como elementos estratégicos no turismo rural em Santana do Livramento-RS/Brasil
Authors:   Universidade Federal do Rio Grande do Sul 8brasil), Bidarte Marcos Vinicius Dalagostini , Pinto Camila dos Santos ,   Universidade Federal do Pampa (Brasil)
Published: March 2022

This study is aimed at analysing the tourism strategies adopted by the owners of Estância da Glória and Fazenda Palomas, true pioneers of rural tourism in the municipality of Santana do Livramento, Brazil using comparative case studies and qualitative content analysis of interviews, observation and photographic records. The results showed that natural, cultural and historical resources have been used in creative interpretations to explore the potential of the properties, adapting their offer of tourist activities to the demand of their market seg‑ ment. It also showed that there was room for improvement. For the owners, entrepreneurship in rural tourism is linked to innovation, to the possibility of integrating tourism with agricultural activities, to generate complemen‑ tary income, preserve their natural resources, conserve their historical and cultural heritage and produce a sense of belonging and identification of the visitors with local/regional culture and history
Estimación de los impactos económicos y sociales de las recreaciones históricas: “Las Bodas de Isabel de Segura” en Teruel (España)
Authors:   Universidad Europea Miguel de Cervantes (España), Fernández-Ramos María-Yolanda , Cabezas Pascual María del Pilar ,   Universidad Europea Miguel de Cervantes (España), Belloso Martín Carlos ,   Universidad Europea Miguel de Cervantes (España)
Published: March 2022

The organisation of tourist events based on historical settings and recreation of the past, may have a positive economic impact, along with tourist and community benefits. For any place considering such events, it is vital to be able to forecast the possible impacts. This article analyses and describes the economic, tourist and community impact of the historical recreation of “Isabel de Segura’s wedding celebrations” in the town of Teruel, an inland tourist destination in Spain. For the study, effect methodology to help us measure the quantitative and qualitative aspects of this great event. It is clear from the results that intangible heritage, based on artistic and monumental heritage, is an advanced resource for tourist competitiveness in such places as it used creatively
New data on the bees of the genus Hylaeus Fabricius, 1793 (Hymenoptera: Colletidae) from the Fars Province, Iran
Authors:   Department of Entomology, Jahrom Branch, Islamic Azad University, Jahrom, Iran, Falahatpisheh A. , Saghaei N. ,   ) Department of Entomology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran, Fallahzadeh M. ,   Department of Entomology, Jahrom Branch, Islamic Azad University, Jahrom, Iran
Published: March 2022

An annotated list of seven species of the genus Hylaeus Fabricius, 1793 collected in the Fars Province of Iran is presented. Two species, H. (Paraprosopis) gujaraticus Nurse, 1903 and H. (P.) taeniolatus Förster, 1871 are new additions to the Iranian bee fauna. Furthermore, five species are new records for the Fars Province. With the current additions, the total number of Hylaeus recorded from the Fars Province and Iran is now increased to 17 and 66 species, respectively.
Microsculpture and chaetotaxy of abdominal tergites of bark and ambrosia beetles (Coleoptera: Curculionidae, Scolytinae): morphology and nomenclature
Authors:   Rostov branch of FSI “VNIIKR”, 20th line, 43/16, Rostov-on-Don 344037, Russia, Kasatkin D.G.
Published: March 2022

The structure of the chaetom and the microsculpture of the abdominal tergites surface are analyzed for 60 species of Scolytinae from different tribes and genera. The typi¬fication and nomenclature of these structures are proposed for the first time. Eight types of microsculptural elements and five types of setae are recognized. The taxonomic significance of these structures is discussed.
On distribution of the shore fly Lamproscatella aklavik Mathis, 1979 (Diptera: Ephydridae) in the Palaearctic Region
Authors:   A.N. Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow 119071, Russia, Krivosheina M.G.
Published: March 2022

The species Lamproscatella aklavik Mathis, 1979 is recorded from Southern Siberia, Republic of Tuva for the first time. Previously this rare species was known from few specimens from the Northwest Territories of Canada (type-locality) and from a single specimen from Central Yakutia.
US legal developments in outer space mining
Authors: Gerałt Bartłomiej
Published: March 2022

In December 2020 NASA (National Aeronautics and Space Administration) announced a contract with a private company to deliver Moon material to Earth, the first and only contract of this type to be concluded to date. The sum that will be paid for the services of Lunar Outpost company was set at 1 US dollar. Although the arrangement may seem like a publicity stunt to catch international media attention, it spurs a legal discussion on the actual degree of freedom to utilized outer space. This article is focused on describing the USA’s policy and legislation concerning the utilization of natural resources of outer space, and comparing it to the international legal framework of outer space activities.
Zrozumieć przestrzeń – zrównoważone postpandemiczne przestrzenie biurowe jako nowy kierunek rozwoju organizacji
Authors: Wojtas Magdalena
Published: March 2022

Spędzamy średnio 90% naszego czasu w pomieszczeniach zamkniętych. Od jakości powietrza, którym oddychamy, po materiały użyte wewnątrz budynki, w których pracujemy, mieszkamy i odpoczywamy, mają ogromny wpływ na nasze zdrowie i samopoczucie. Przestrzenie, w jakich przebywamy, odgrywają kluczową rolę w zapobieganiu rozprzestrzeniania się chorób. Zrównoważone budynki chronią zasoby naturalne, stawiają na dobrą wentylację i są wysoce energooszczędne. Zmniejszają ilość odpadów i zanieczyszczenie powietrza oraz są budowane z nietoksycznych, zrównoważonych materiałów. W niniejszym artykule przedstawiono trendy związane ze zrównoważonym budownictwem w kontekście kreowania przestrzeni biurowych w kierunku zdrowych, bezpiecznych i elastycznych miejsc pracy w czasach pandemicznych oraz postpandemicznych.
ANALYSIS OF VARIABILITY OF BIOMETRIC INDICATORS IN NEMATANTHUS (NEMATANTHUS SCHRAD.)
Authors: Симахин М.В. , Шевцова А.А. , Козлова Е.А. , Аниськина Т.С. , Донских В.Г. , Орлова Е.Е. , Покиньчереда А.М. , Карнаухова Д.С.
Published: March 2022

В настоящей работе рассмотрен анализ изменчивости количественных признаков надземных и подземных органов нематантуса голого (Hypocyrta glabra Hook. или Nematanthus strigillosus (Mart.) H.E. Moore): длина самого длинного корня, средняя длина корней первого порядка, длина надземной части, средняя длина листа, средняя ширина листа. Опыт проведен по полной двухфакторной схеме. Оценена изменчивость при использованию торфа или смеси перлита и вермикулита, а также при обработке регуляторами роста Циркон и Эпин в смеси с Экофусом. Для оценки анализа изменчивости использовался метод доверительных интервалов и расчет коэффициентов вариации. Отмечено, что варьирование всех параметров в вариантах слабое или среднее. Таким образом, изученные черенки нематантуса голого незначительно отличаются друг от друга, что свидетельствует о выровненности посадочного материала.

This work analyzes the variability of the quantitative traits of the aboveground and underground organs of the naked nematanthus (Hypocyrta glabra Hook. Or Nematanthus strigillosus (Mart.) H.E. Moore): root length, average root length of the first order, length of the aerial part, average leaf length, average leaf width. The experiment was carried out according to the full two-factor scheme. The variability was assessed when using peat or a mixture of perlite and vermiculite, as well as when treated with growth regulators Zircon and Epin in a mixture with Ekofus. To assess the analysis of variability, the method of confidence intervals and the calculation of the coefficients of variation were used. It is noted that the variation of all parameters in the variants is weak or medium. Thus, the studied cuttings of naked nematanthus slightly differ from each other, which indicates the evenness of the planting material
OPTIMIZATION OF THE CONTENT OF CAESIUM-137 IN DAIRY PRODUCTS
Authors: Остроухова В.И. , Смолина Г.А. , Ананьева Т.В.
Published: March 2022

137Cs поступает в организм человека преимущественно алиментарным путем с пищевыми продуктами и практически полностью всасывается в пищеварительном тракте, вызывая необратимые изменения. Содержание 137Cs в молоке из разных регионов варьирует в широком диапазоне, при этом небольшое количество радионуклида обнаруживается даже на условно-чистых территориях. Таким образом, представляет интерес изучить трансформацию 137Cs при получении и переработке молока в условиях животноводческого хозяйства, расположенного в черте мегаполиса (г. Москва), не относящегося к зоне радионуклидных загрязнений.

137Cs enters the human body mainly by alimentary route with food and is almost completely absorbed in the digestive tract, causing irreversible changes. The content of 137Cs in milk from different regions varies in a wide range, while a small amount of radionuclide is detected even in conditionally clean territories. Thus, it is of interest to study the transformation of 137Cs during the production and processing of milk in the conditions of a livestock farm located within the megalopolis (Moscow), which does not belong to the zone of radionuclide contamination.
AGE STRUCTURE OF THE CAUCASIAN TOAD (BUFO VERRUCOSISSIMUS) ON THE STAVROPOL UPLAND (BASED ON STUDY OF ROAD KILLED SPECIMENS)
Authors: Африн К.А. , Степанкова И.В. , Кидов А.А.
Published: March 2022

В работе приведены результаты изучения возраста погибших взрослых кавказских жаб (Bufo verrucosissimus), собранных на автомобильных дорогах в станице Новоекатериновская (Кочубеевский муниципальный округ, Ставропольский край, Россия) в период с 4 по 8 мая. Всего были изучены препараты от 19 животных (7 самок и 12 самцов). Возраст изученных самцов составил 3–7 лет, а самок – 5–12 лет. Самые крупные животные не относятся к самой старшей возрастной категории. На основании изучения срезов трубчатых костей авторы предполагают наличие у этого вида как зимнего, так и летнего периода замедления роста (эстивация).

The article presents the results of studying the age of dead adult Caucasian toads (Bufo verrucosissimus) collected on roads in the village of Novoekaterinovskaya (Kochubeevskiy Municipal District, Stavropol Krai, Russia) in the period from 4 to 8 May. In total, preparations from 19 animals (7 females and 12 males) were studied. The age of investigated males was 3–7 years, and females 5–12 years. The largest animals did not belong to the oldest age category. Based on the study of sections of tubular bones, the authors assume that this species has both a winter and a summer period of arrested growth (estivation).
CURRENT DISTRIBUTION OF THE COMMON SMOOTH NEWT, LISSOTRITON VULGARIS (AMPHIBIA, SALAMANDRIDAE) IN NEW MOSCOW
Authors: Степанкова И.В. , Африн К.А. , Иволга Р.А. , Кидов А.А.
Published: March 2022

Обыкновенный тритон, Lissotriton vulgaris – один из самых распространенных и массовых видов земноводных в Северной Евразии. В Москве численность вида сокращается, из-за чего он был включен в региональную Красную книгу. В работе представлены результаты исследования распространения L. vulgaris на территории Троицкого и Новомосковского административных округов Москвы. Исследования осуществляли в период с 2018 по 2021 гг. В результате мониторинга обыкновенный тритон был найден в 24 локалитетах (6 точек находок в Новомосковском и 18 – в Троицком административных округах). Для того, чтобы способствовать устойчивому существованию L. vulgaris в Новой Москве авторы рекомендуют сохранять и создавать эфемерные водоемы на участках древесной растительности.

The common smooth newt, Lissotriton vulgaris, is one of the most widespread and numerous amphibian species in Northern Eurasia. In Moscow, the common smooth newt’s abundance is decreasing, that is why it was included in the regional Red Book. The paper presents the results of a study of the distribution of L. vulgaris in Troitsky and Novomoskovsky administrative districts of Moscow. The studies were carried out in the period from 2018 to 2021. As a result of monitoring, a common smooth newt was found in 24 localities (6 localities in Novomoskovsky and 18 in Troitsky administrative districts). In order for the self-sustaining populations of L. vulgaris in New Moscow, it is recommended to preserve and create vernal ponds in forest areas.
PROSPECTIVE BEGINNING OF SEARCH AND APPRAISAL WORKS ON THE TITONIAN SEDIMENTS OF THE UPPER JURASSIC OF THE TERSKO-SUNZHENSKAYA OIL AND GAS REGION
Authors: Лабазанов М.М. , Халадов А.Ш. , Кулешова Л.С. , Велиев Э.М. , Дамзаев З.М. , Мусаева П.У. , Умаев А.А. , Алиев И.И. , Газабиева З.Х. , Дудаева М.А. , Шахбазов Т.Г.
Published: March 2022

Целесообразность проведения ГРР на территории Чеченской Республики обосновывается состоянием сырьевой базы углеводородного сырья и высокой степенью выработанности (в среднем 98,2 %) ранее разведанных и активно разрабатываемых в настоящее время месторождений, а также наличием перспектив для обнаружения новых залежей (месторождений) нефти и газа в прибортовых и синклинальных зонах ТКП. Основные перспективы нефтегазоносности Терско-Каспийского прогиба в связи с истощением миоценовых и меловых залежей УВ связаны с поиском объектов бурения в валанжин-юрском карбонатном комплексе отложений. На Заманкульском, Малгобек-Вознесенском и Харбижинском месторождениях в валанжинских и юрских надсолевых породах открыты залежи нефти. На Датыхской площади притоки нефти и газа получены из верхней соленосной и межсолевой толщ юры. На Марьинской площади из межсолевой толщи был получен промышленный приток нефти. Из подсолевых отложений на Датыхской и Куркужин-Заюковской площадях был получен промышленный приток газа, а на Чегемской площади – нефти и конденсата.

The expediency of geological exploration in the Chechen Republic is justified by the state of the raw material base of hydrocarbon raw materials and a high degree of depletion (on average 98.2 %) of previously explored and currently actively developed fields, as well as the presence of prospects for discovering new deposits (deposits) of oil and gas in near-side and synclinal zones of the TCH. The main prospects for the oil and gas potential of the Terek-Caspian trough in connection with the depletion of the Miocene and Cretaceous hydrocarbon deposits are associated with the search for drilling targets in the Valanginian-Jurassic carbonate complex of deposits. Oil deposits have been discovered in the Valanginian and Jurassic post-salt rocks at the Zamankul, Malgobek-Voznesensky and Kharbizhinsky fields. In the Datykh area, oil and gas flows were obtained from the upper salt-bearing and inter-salt strata of the Jurassic. In the Maryinskaya area, an industrial flow of oil was obtained from the inter-salt strata. From the subsalt deposits at the Datykhskaya and Kurkuzhin-Zayukovskaya areas, an industrial flow of gas was obtained, and at the Chegemskaya area – oil and condensate.
Synthesis and styrene copolymerization of novel difluoro and chlorofluoro ring-disubstituted isobutyl phenylcyanoacrylates
Authors: Ahlers Christopher D. , Ahmed Aisha A. , Alam Umamah , Sajwani Alima A. , Salloum Megan V. , Schneider Makayla A. , Serra Heysel M. , Tanawath Richard C. , Triolo Gabriella L. , Velazquez Marisol , Rocus Sara , Schjerven William , Kharas Gregory
Published: March 2022

Novel difluoro and chlorofluoro ring-disubstituted isobutyl phenylcyanoacrylates, RPhCH=C(CN)CO2CH2CH(CH3)2 (where R is 2,3-difluoro, 2,4-difluoro, 2,6-difluoro, 3,4-difluoro, 3,5-difluoro, 2-chloro-4-fluoro, 2-chloro-6-fluoro, 3-chloro-2-fluoro, 3-chloro-4-fluoro, 4-chloro-3-fluoro) were synthesized by the piperidine catalyzed Knoevenagel condensation of ring-disubstituted benzaldehydes and isobutyl cyanoacetate and characterized by CHN analysis, IR, 1H and 13C NMR. The acrylates were copolymerized with styrene in solution with radical initiation at 70C. The compositions of the copolymers were calculated from nitrogen analysis.
Selective and Reversible Polysulfide-macrocycle Binding at Modified Membranes Suppress Shuttling in Lithium Sulfur Batteries
Authors: Benson Christopher , Cui Yi , Guo Wei , Zhao Wei , Karty Jonathan , Zhu Likun , Fu Yongzhu , Flood Amar
Published: March 2022

Lithium sulfur (LiS) batteries are among the next generation of rechargeable batteries offering high energy densities. Obstacles remain for their practical application, such as capacity fading and low Coulombic efficiency resulting from shuttling and reaction of polysulfides with the Li anode. A new supramolecular approach to suppress shuttling using reversible binding of anionic polysulfides, e.g., S3•–, S62–, S72–, S82–, by anion-selective receptors, called cyanostar (CS) macrocycles is reported. Standard separators were coated with the macrocycles and formed chemically selective membranes. Unlike adsorption materials and non-selective supramolecular approaches, cyanostar provides a well-defined molecule-to-molecule mechanism to capture polysulfides as host-guest complexes like (CS)2•S3•– and (CS)4•S72–. Permselectivity emerges from reversibly binding polysulfides inside the membrane to prevent anions passing while allowing cations to pass. Controls using macrocycles that are not selective for anions do not stop shuttling. Cyanostar-coated membranes turn on charging, reduce capacity fading from 0.51 to 0.36% per cycle and improve Columbic efficiency to 85%. These improvements occur even without addition of lithium nitrate used almost universally to inhibit reactions with the Li anode. This new strategy showcases the benefits of using selective receptors to manage movement of ions in sulfur-based batteries.
Design, Synthesis and Biological Characterization of Histone Deacetylase 8 (HDAC8) Proteolysis Targeting Chimeras (PROTACs) with Anti-Neuroblastoma Activity
Authors: Darwish Salma , Ghazy Ehab , Heimburg Tino , Herp Daniel , Zeyen Patrik , Ridinger Johannes , Schmidtkunz Karin , Robaa Dina , Erdmann Frank , Schmidt Matthias , Romier Christophe , Jung Manfred , Oehme Ina , Sippl Wolfgang
Published: March 2022

While histone deacetylases (HDACs) are known as modulators of epigenetic gene regulation, they also control the activity of non-histone protein substrates. The isozyme HDAC8 plays a role in inhibiting apoptosis and increasing cancer cell proliferation. As a result, HDAC8 is considered a potential target in the treatment of cancer forms such as T-cell lymphoma, gastric adenocarcinoma, hepatocellular carcinoma, and childhood neuroblastoma. The present work describes the development of proteolysis targeting chimera (PROTAC) of HDAC8 based on substituted benzhydroxamic acids previously reported as potent and selective HDAC8 inhibitors. Within this study, we have developed the first in class HDAC8 selective PROTAC and investigated the effect on protein degradation and on the proliferation of neuroblastoma cells. The combination of structure-guided synthesis, in vitro screening and cellular testing resulted in cereblon (CRBN) based HDAC8 PROTACs that showed anti-neuroblastoma activity in cells.
A General and Modular Access to Enantioenriched α Trifluoromethyl Ketones via Nickel-Catalyzed Reductive Cross-Coupling
Authors: Chen Liang-An , Lin Dengkai , Chen Yongzhi , Dong Zhan , Pei Pan , Ji Haiting , Tai Lanzhu
Published: March 2022

The development of new catalytic enantioselective access to CF3-containing stereogenicity is of great interest for the expediting discovery of lead compounds yet remains challenging. We devised a general and modular approach to facilely access enantioenriched α-CF3 ketones via nickel-catalyzed reductive cross-coupling of readily available acid chlorides and racemic α-CF3 alkyl bromides in an enantioconvergent fashion under mild conditions. This protocol featured neighboring directing group-free, high chemoselectivity, excellent functional group tolerance, facile scale-up, and notable amenability to straightforward downstream elaboration toward molecule complexity, thus constituting a reliable, direct, practical, and efficient synthetic alternative to furnish enantiopure α-CF3 carbonyls. Interestingly, an appropriate choice of the phosphine ligand as co-ligand plays an important role in high efficiency and asymmetric induction. Mechanistic studies suggest a radical chain pathway.
Do machines dream of atoms? A quantitative molecular benchmark for explainable AI heatmaps
Authors: Rasmussen Maria H. , Christensen Diana S. , Jensen Jan H.
Published: March 2022

While there is a great deal of interest in methods aimed at explaining machine learning predictions of chemical properties, it is difficult to quantitatively benchmark such methods, especially for regression tasks. We show that the Crippen logP model (J. Chem. Inf. Comput. Sci. 1999, 39, 868) provides an excellent benchmark for atomic attribution/heatmap approaches, especially if the ground truth heatmaps can be adjusted to reflect the molecular representation. The ”atom attribution from finger prints”-method developed by Riniker and Landrum (J. Chem. Inf. Comput. Sci. 2013, 5, 43) gives atomic attribution heatmaps that are in reasonable agreement with the atomic contribution heatmaps of the Crippen logP model for most molecules, with average heatmap overlaps of up to 0.54. The agreement is increased significantly (to 0.75) when the atomic contributions are adjusted to match the fact that the molecular representation is fragment-based rather than atom-based (the finger print-adapted (FPA) ground truth vector). Most heatmaps and the corresponding FPA overlaps are relatively insensitive to the training set size and the results are close to converged for a training set size of 1000 molecules, although for molecules with low overlap some heatmaps change significantly. Heatmaps of the prediction uncertainty and the uncertainty in the atomic attributions can help identify molecular regions that contribute significantly to errors in the logP prediction and/or attribution and these heatmaps can be used to guide the design of counterfactual examples to probe the ML model further. Like the simpler attribution benchmarks for classification tasks that have come before it, this work sets the bar for regression tasks.
On the binding energy of atoms in crystals and the speed of sound
Authors: Dall'Osso Aldo
Published: March 2022

The speed of sound depends on the structure and on the material properties of the crystal, such as the density and the Young’s modulus. On the other hand, from atomistic arguments it is possible to link the Young’s modulus to other material properties. These observations drive to a relation between the binding energy of the atoms in a crystal (which is one of the parameters appearing in the Mie-Lennard-Jones potential), the speed of sound in the longitudinal direction and the mass of one atom in the lattice. Applications of this relation to rare gases and few metals are presented and the results compared to others taken from literature.
Triple-element stable isotope analysis of chloromethane emitted and degraded by royal fern and club moss
Authors: Hartmann S. Christoph , Keppler Frank , Greule Markus , Lauer Rebekka , Horst Axel
Published: March 2022

In this study we explored the potential benefits of triple element isotope analysis (2H, 13C, 37Cl) of CH3Cl emitted by royal fern (Osmunda regalis) and degradation by a club moss (Selaginella kraussiania). CH3Cl emitted by royal fern showed depleted isotopic values for all elements compared to anthropogenically produced CH3Cl which bodes well for the distinction of different sources. Degradation by club moss showed relatively large stable chlorine isotope effects consistent with other dechlorination reactions. Stable hydrogen and stable chlorine isotope fractionation were larger for hydrogen and smaller for carbon which may indicate a yet unreported degradation mechanism for CH3Cl
Synthesis and structural properties of a 2D Zn(II) dodecahydroxy-closo-dodecaborate coordination polymer
Authors: Ready Austin , Becwar Shona , Jung Dahee , Schueller Emily , Anderson Kierstyn , Kubena Rebecca , Seshadri Ram , Chmelka Bradley , Spokoyny Alexander
Published: March 2022

In this work, we discuss the synthesis and characterization of a 2D coordination polymer composed of a dianionic perhydroxylated boron cluster, [B12(OH)122-], coordinated to Zn(II)—the first example of a transition metal-coordinated [B12(OH)12]2- compound. This material was synthesized via cation exchange from the starting cesium salt and then subjected to rigorous characterizion prior to and after thermal activation. Numerous techniques, including XRD, FTIR, SEM, TGA, and solid-state NMR revealed a 2D coordination polymer composed of sheets of Zn(II) ions intercalated between planes of boron clusters. The as-synthesized material was then evacuated of solvent via thermal treatment, and atomic-level changes from this transformation were elucidated through a combination of 1D and 2D solid-state NMR analyses of 11B and 1H nuclei, suggesting the full removal of coordinated solvent molecules. Evidence also suggested that [B12(OH)122-] can adjust its coordination to Zn(II) in the solid-state through hemilability of its numerous -OH ligands.
Measures for the Construction Cost Budget and Settlement Audit
Authors: Peng Zhenghong
Published: March 2022

With the deep and sustainable development of the market economy, the competitive environment and development pattern faced by China’s construction industry are becoming more and more severe. In this context, construction projects should actively incorporate the development trends of the market economy and focus on analyzing relevant influencing factors and risk content. Considering previous experience, the audit effect of construction project budget and settlement has a major impact on the quality and economic benefit of construction projects to a certain extent. In view of this, this paper mainly focuses on the content and method of the construction cost budget and settlement audit as well as suggests measures for the construction cost budget and settlement audit, so as to improve the construction cost management level.
Strategi Pengembangan Penulisan Karya Ilmiah pada Guru di Kabupaten Sidoarjo
Authors: Wardoyo Dewie Tri Wijayati , Kautsar Achmad , Fazlurrahman Hujjatullah
Published: March 2022

Every teacher is obliged to carry out various activities in carrying out his duties and responsibilities. The scope of the teacher's activities includes (1) attending education, (2) handling the learning process, (3) conducting professional development activities and (4) supporting activities. The two partners of this activity have the same problem, namely, the teachers still have difficulty in making scientific papers. Whereas professional teachers expect to be able to pursue a career with scientific work for promotion. When viewed from the facts in the field (both partners), only 20% of teachers can write good scientific work.Methods of training, mentoring and monitoring to resolve partner issues that have been mutually agreed upon and stages in achieving the solutions offered to overcome the main problems of partners in the period of program realization. In the initial conditions before the training, only 7 teachers had PTK designs, but after training and mentoring, there were 20 teachers who drafted PTK proposals, the remaining 5 were still constrained.
Pelatihan Game Edukasi Android Berbasis HOTS Sebagai Media Evaluasi Pembelajaran
Authors: Dewi Retno Mustika , Sholikhah Ni'matush , Ghofur Muhammad Abdul , Soejoto Ady
Published: March 2022

Rendahnya kemampuan pemecahan masalah dan berpikir kritis adalah siswa Indonesia hanya menguasai soal-soal dengan karakteristik yang bersifat rutin dan sederhana, siswa belum mampu dalam menganalisa soal yang lebih kompleks dan bersifat pemecahan masalah. Dibuktikan dengan data dari Dinas Pendidikan Jawa Timur sebanyak 78,88%  nilai ujian nasional SMA dan SMK  dibawah 55. Tujuan  Pelatihan dalam Pengabdian Kepada Masyarakat ini adalah memberikan pelatihan penyusunan alat evaluasi berbasis HOTs melalui penggunaan game Edukasi android. Mitra pengabdian adalah guru MGMP Se Kabupaten Magetan. Metode yang dilakukan diantaranya ceramah, praktek, diskusi dan Tanya jawab.  PKM dilaksanakan pada tanggal 3 Agustus 2019 bertempat di SMAN 3 Magetan dihadiri 16 peserta. Kelebihan dalam game aplikasi berbasis android ini, guru tidak disibukkan dalam enghitung skor hasil belajar peserta didik karena aplikasi tersebut dapat menampilkan nilai masng masing peserta didik secara otomatis. Guru tidak perlu khawatir terhadap kecurangan peserta didik ketika menerapkan aplikasi ini, karena ketika menggunakan aplikasi tersebut peserta didik harus log in terlebih dahulu dan aplikasi ini bersifat satu aplikasi satu akun. Tingkat pemahaman guru tentang praktek game  aplikasi berbasis android setelah mengikuti pelatihan yakni 73 dari skor 100. Dari hasil pemberian post test tersebut, menunjukkan tingkat pemahaman guru terhadap praktek game aplikasi berbasis android terbilang cukup.
Penguatan Ketahanan Pangan untuk Pekerja Informal, Dhuafa dan Pedagang Kecil dalam Menghadapi Economic Shock Akibat Pandemi Covid-19
Authors: Hadi Hafid Kholidi , Fazlurrahman Hujjatullah , Indawati Nurul , Rozaq Khoirur , Rahman Zainur , Fatoni Fandi
Published: March 2022

East Java, especially Surabaya City is the city with the highest number of people affected by the Covid-19 virus. As the capital city of East Java Province, Surabaya is the center of administrative services, offices, services, shopping, industry and other supporting sectors. With the Covid-19 virus pandemic spreading so fast, the provincial governments of East Java and the City of Surabaya issued regulations for working at home, studying at home, and limiting activities that led to large gatherings of people. Problems arise when the activities of schools, agencies, offices are reduced, so small traders, informal workers, motorcycle taxis, and some informal workers are economically affected. As well as government regulations that must be obeyed in tackling the Covid-19 pandemic, it also needs to be understood. This community service has a target of increasing endurance, especially in terms of meeting basic needs. The implementer understands that in terms of their income is directly affected, the provision of these staples is so that they do not experience an economic shock. So that later they can stay active and look for income to meet family needs.
PKM Pengasuhan Positif Anak Usia Dini Di Desa Kedak Kabupaten Kediri
Authors: Utomo Hanggara Budi , Ridwan Ridwan , Kurniawati Epritha , Dwiyanti Linda
Published: March 2022

Pola asuh orang tua selama ini masih cenderung melakukan pengasuhan negatif untuk anaknya yang masih usia dini, dan orang tua belum memahami tentang pengetahuan dan kesadaran orang tua tentang pengasuhan positif. Tujuan dilakukan kegiatan adalah untuk mensosialisasikan model pengasuhan positif anak usia dini pada masyarakat. Metode yang diterapkan adalah metode ceramah, tanya jawab, dan diskusi, serta evaluasi. Adapun hasil pelaksanaan kegiatan pengabdian kepada masyarakat, antara lain: dukungan yang besar dari perangkat desa dimana hal ini terbukti dari keterlibatan dalam memberikan fasilitas penyelenggaraan sosialisasi; antusiasme warga masyakarakat untuk berpartisipasi aktif mengikuti kegiatan sosialisasi pengasuhan positif anak usia dini sampai selesai dan adanya kemauan dari peserta untuk belajar dan berbagi pengalaman terkait pola asuh; permasalahan yang diajukan dan ditemukan merupakan permasalahan yang sesuai dengan arah pengembangan dan hasil diskusi dengan pendidik PAUD di desa Kedak Kecamatan Semen Kabupaten Kediri; harapan selanjutnya, kegiatan sosialisasi maupun parentinf khususnya yang berkaitan dengan pendidikan anak usia dini dapat dilaksanakan kembali dikemudian hari, dikarenakan selama ini baru pertama kali dilaksanakan kegiatan tersebut. Kegiatan pengasuhan ini memberikan pengetahuan dan kesadaran kepada masyarakat Desa Kedak Kecamatan Semen Kabupaten Kediri akan pentingnya pengasuhan positif untuk anak usia dini.
Coaching Small Industries Kerupuk Kawasan Wisata Ujungpangkah Kabupaten Gresik
Authors: Ratnawati Tri , Lokajaya I Nyoman
Published: March 2022

Raw materials for making crackers in the form of fish are very abundant in this village and most people make a living as fishermen and fish pond farming. Fish used as raw material for making crackers are payus fish and laosan. The cracker industry produced by most of the craftsmen in Ujung Pangkah sub-district, Gresik Regency, the majority are sold in the form of 'raw crackers' at very cheap prices, simple packaging, less attractive shapes and marketed in the local area, so the product quality must be improved. Fish crackers are crackers whose ingredients consist of a mixture of flour and fish meat. Many types of fish can be used as a basis for making crackers. Payus fish (Elops hawaiensis) is one of the predatory fish species of small fish and crustaceans in ponds. The existence of this fish is quite abundant so that it can be used as a product that can be consumed by the community. Coaching assistance and in the form of providing manual dough cutting machine tools accelerate the production process and production cost efficiency. Assistance with the production process has been carried out through quality control, micro marketing (Instragram and Facebook), financial management reporting through microfinance accounting processes.
Profil Pemahaman Konsep Peserta Didik SMP Pada Materi Kalor dan Perpindahannya
Authors: Hutomo Bagus Addin , Suryaningsih Yuliana , Subali Bambang , Marwoto Putut
Published: March 2022

The heat and displacement is one of the material in science learning taught at the junior high school level. This study aims to describe the profile of the conceptual understanding of Class VIII junior high school students on matter of heat and displacement. The design of this study is a descriptive study concerning the understanding of the concept of junior high school students in material heat and displacement with a quantitative approach. The subjects in this study were 27 students of class VIII D Kesatrian 1 Semarang junior high school. The sampling technique uses probability sampling techniques with simple random sampling technique. The data collection method used is a test instrument in the form of a two-level multiple choice question that has been validated by experts. The results of this study found that understanding the heat concept and its displacement of 7% in the criteria were very low, as much as 26% in the low category, 48% in the medium category, 15% in the high category, and by 1% the criteria were very high. Based on the results of the research, it can be concluded that the percentage of understanding of the concept of heat material and its displacement is the largest in the medium category.