bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the Multifaceted Biological Activities of Anthocyanins Isolated from Two Andean Berries
Authors: Barba-Ostria Carlos , Carrera-Pacheco Saskya E. , Gonzalez-Pastor Rebeca , Zuñiga-Miranda Johana , Mayorga-Ramos Arianna , Tejera Eduardo , Guamán Linda P.
Published: August 2024

Natural pigments extracted from plant species are used in foods, cosmetics, and pharmaceuticals. This study evaluates the comprehensive biological activities of anthocyanins isolated from Andean blueberry (Vaccinium floribundum Kunth) and Andean blackberry (Rubus glaucus Benth), focusing on their antimicrobial, antioxidant, antitumoral, anti-inflammatory, and hemolytic properties. Chemical characterization revealed significant anthocyanin content with complex mass spectrometric profiles indicating diverse glycosylation patterns that may influence their bioactivity. The antimicrobial assays showed that the extracts were particularly effective against Gram-positive bacteria, with minimal inhibitory concentrations (MICs) as low as 1 mg/mL for Rubus glaucus, indicating strong potential for therapeutic use. The antioxidant capacity of the berries was substantial, albeit slightly lower than that of ascorbic acid. The extracts also exhibited notable antitumoral activity in various cancer cell lines, showing promise as adjunctive or preventive treatments. The anti-inflammatory effects were confirmed by inhibiting nitric oxide production in macrophage cells, highlighting their potential in managing inflammatory diseases. In terms of hemolytic activity, Rubus glaucus exhibited dose-dependent effects, potentially attributable to anthocyanins and phenolics, while Vaccinium floribundum demonstrated no significant hemolytic activity, underscoring its safety. These findings suggest that anthocyanins from Andean berries possess potent biological activities, which could be leveraged for health benefits in pharmaceutical and nutraceutical applications. Further studies are needed to isolate specific bioactive compounds and investigate their synergistic effects in clinical and real-world contexts.
Vasorelaxant Effect and Blood Pressure Reduction Potential of Pitaya Juice Concentrate (Stenocereus huastecorum) Associated with Calcium Channel Blockade
Authors: Ramírez-Rodríguez Yadira , Espinosa-Tanguma Ricardo , Valle-Aguilera Juan Roberto , Rodríguez-Menchaca Aldo A. , Saderi Nadia , Salgado-Delgado Roberto , Bautista Elihú , Garcés Luis , Ramírez Victoria , Robledo-Márquez Karina , Riego-Ruiz Lina , Trujillo Joyce
Published: August 2024

Arterial hypertension is a highly prevalent chronic disease worldwide, with several etiologies and treatments that may eventually have side effects or result in patients developing tolerance. There is growing interest in traditional medicine and functional foods to isolate biomolecules that could be useful as coadjuvants for treating several aliments. Pitaya, a desert fruit endemic in Mexico, is a rich source of bioactive molecules (betalains and phenolic compounds). In this work, the vasorelaxation properties of pitaya juice concentrate and fraction one were investigated using aortic and mesenteric rings from rats. The incubation of rings with pitaya juice concentrate or fraction one induced significant vasorelaxation, independent of the endothelium, and showed resistance to potassium channel blockers. This vasorelaxation was associated with the transmembrane influx of extracellular calcium through the vascular smooth muscle cells, with an inhibitory effect on the voltage-dependent calcium channel currents. Also, 400 mg/mL of pitaya juice concentrate in spontaneous hypertensive rats reduced their blood pressure for 48 h. Phytochemical analyses showed that the primary compounds in F1 were glycosidic in nature, and could be a complex mixture of disaccharides, dimeric disaccharides, or even tetrasaccharides. The glycosidic compounds found in F1 primarily contributed to vasodilatation, establishing a voltage-dependent calcium channel inhibition as a possible molecular target.
Recent Applications of Near-Infrared Spectroscopy in Food Quality Analysis
Authors: Nadimi Mohammad , Paliwal Jitendra
Published: August 2024

With the ever-increasing global population, food demand will continue to increase in the coming decades [...]
Tracking the Mandorla di Avola Almond Variety by Means of ICP Analysis
Authors: Gulino Federica , Siragusa Cassandra , Calà Elisa , Gullo Francesca , Aceto Maurizio
Published: August 2024

The Mandorla di Avola is recognized all over the world as one of the best almond varieties. It is cultivated in a small area inside the provinces of Siracusa and Ragusa (Sicily, southern Italy). It is used in traditional Sicilian cuisine for both salty and sweet foods and of course in artisan pastry, apart from being consumed as a fruit. Due to its extraordinary organoleptic and beneficial features, the Mandorla di Avola is frequently counterfeit with almond varieties of lower quality coming from other countries. While its nutraceutical features have been studied, the possibility of authenticating it with respect to other varieties has not been explored. In this work, we used microelements determined with ICP-OES and ICP-MS as chemical descriptors to distinguish samples of Mandorla di Avola almonds from almonds coming from California and Spain, which are usually employed as substitutes in pastry. Among the different elements determined, Mn and P were found to be the best descriptors for authentication.
Insight into the Probiogenomic Potential of Enterococcus faecium BGPAS1-3 and Application of a Potent Thermostable Bacteriocin
Authors: Popović Nikola , Veljović Katarina , Radojević Dušan , Brdarić Emilija , Stevanović Dušan , Živković Milica , Kojić Milan
Published: August 2024

This study aimed to investigate the probiogenomic features of artisanal bacteriocin-producing Enterococcus faecium BGPAS1-3 and the use of the improved pMALc5HisEk expression vector for overexpressing class II bacteriocins and the application of purified bacteriocin 31 in a milk model as a preservative against L. monocytogenes. The BGPAS1-3 strain was isolated from traditional fresh soft cheese manufactured in households on a small scale in rural locations surrounding Pale Mountain City in Bosnia and Herzegovina. The whole-genome sequencing approach and bioinformatics analyses revealed that the strain BGPAS1-3 was non-pathogenic to humans. The presence of bacteriocin operons suggested the ability of the isolate to suppress the growth of pathogens. Coding regions for three maturated bacteriocins (bacteriocin 31, bacteriocin 32, and enterocin P) produced by BGPAS1-3 were amplified and expressed in Escherichia coli ER2523 using the pMALc5HisEk system. All three bacteriocins were successfully overexpressed and purified after enterokinase cleavage but showed different antimicrobial activity. Bacteriocin 31 showed significantly stronger antimicrobial activity compared with bacteriocin 32. It was the only one that proved to be suitable for use as a food preservative against L. monocytogenes in a milk model.
Banana Peel Extract-Derived ZnO Nanopowder: Transforming Solar Water Purification for Safer Agri-Food Production
Authors: Jovanović Dušica , Bognár Szabolcs , Despotović Vesna , Finčur Nina , Jakšić Sandra , Putnik Predrag , Deák Cora , Kozma Gábor , Kordić Branko , Šojić Merkulov Daniela
Published: August 2024

Pure water scarcity is the most significant emerging challenge of the modern society. Various organics such as pesticides (clomazone, quinmerac), pharmaceuticals (ciprofloxacin, 17α-ethynilestradiol), and mycotoxins (deoxynivalenol) can be found in the aquatic environment. The aim of this study was to fabricate ZnO nanomaterial on the basis of banana peel extract (ZnO/BPE) and investigate its efficiency in the photocatalytic degradation of selected organics under various experimental conditions. Newly synthesized ZnO/BPE nanomaterials were fully characterized by the XRD, FTIR, SEM-EPS, XPS, and BET techniques, which confirmed the successful formation of ZnO nanomaterials. The photocatalytic experiments showed that the optimal catalyst loading of ZnO/BPE was 0.5 mg/cm3, while the initial pH did not influence the degradation efficiency. The reusability of the ZnO/BPE nanomaterial was also tested, and minimal activity loss was found after three photocatalytic cycles. The photocatalytic efficiency of pure banana peel extract (BPE) was also studied, and the obtained data showed high removal of ciprofloxacin and 17α-ethynilestradiol. Finally, the influence of water from Danube River was also examined based on the degradation efficiency of selected pollutants. These results showed an enhanced removal of ciprofloxacin in water from the Danube River, while in the case of other pollutants, the treatment was less effective.
Risk Assessment of Nephrotoxic Metals in Soil and Water in Areas with High Prevalence of Chronic Kidney Disease in Panama
Authors: Valdés-Rodríguez Benedicto , Montero-Campos Virginia , Siebecker Matthew G. , Zimmerman Amanda Jo , Vega-Araya Mauricio , Ulate Chacón Sharon P. , Rovira Dalys
Published: August 2024

Mesoamerican nephropathy (MeN) is a non-traditional chronic kidney disease in some areas of Mesoamerica. The health risk from nephrotoxic metals, such as arsenic (As), lead (Pb), mercury (Hg), vanadium (V), cadmium (Cd), rubidium (Rb), chromium (Cr), and nickel (Ni), was assessed in drinking water and soils. These metals, even at low concentrations, have the capacity to induce epigenetic damage and a nephrotoxic effect. The quantification of metals in soils was made through X-ray fluorescence spectrometry (XRF) and inductively coupled plasma optical emission spectrophotometry (ICP-OES), while the quantification of metals in water was carried out through inductively coupled plasma mass spectrometry (ICPMS) and atomic absorption (AA) spectrometry. The levels of As, Hg, Cd, and V in water were within the permissible limits, whereas Pb was found to be double and triple the value recommended by the World Health Organization. The non-carcinogenic risk from As in soil was evaluated using the Hazard Index (HI), and the route of ingestion was found to be the most important route. The results indicate that consuming water or ingesting soil particles with Pb and As poses a health risk to humans. Therefore, these findings identify the presence of toxicants in an exposure scenario and justify further research into these metals in people and the analysis of exposure routes.
Ground Penetrating Radar (GPR) Investigations in Urban Areas Affected by Gravity-Driven Deformations
Authors: Famiglietti Nicola Angelo , Miele Pietro , Massa Bruno , Memmolo Antonino , Moschillo Raffaele , Zarrilli Luigi , Vicari Annamaria
Published: August 2024

The 1980 Ms 6.9 Irpinia earthquake was responsible for the activation or reactivation of numerous gravitative deformations mainly hosted by clayey lithotypes, affecting wide areas of Benevento Province and the Sele and Ofanto R. Valleys. The case of Calitri offers valuable insights into a methodological approach to studying mass movements affecting human settlements. Post-earthquake investigations in Calitri involved extensive geognostic boreholes and in situ surveys, providing substantial data for lithological characterization and landslide modeling. Additionally, over the past two decades, satellite-based techniques have supported the mapping and characterization of ground deformations in this area, improving our understanding of spatiotemporal evolution. Despite these efforts, a detailed subsurface comprehensionof the tectono-stratigraphy and geometriesof gravity-induced deformation remains incomplete. This study aims to enhance our knowledge of gravity-driven deformations affecting urban areas by using deep-penetrating GroundPenetrating Radar (GPR) surveys to identify landslide-related structures, rupture surfaces, and lithological characterization of the involved lithotypes. The integration of GPR surveys with classical morphotectonic analysis led to the delineation of the main subsurface discontinuities (stratigraphy, tectonics, and gravity-related), correlating them with available geognostic data. This approach provided non-invasive, detailed insights into subsurface features and stands out as one of the rare case studies in Italy that employed the GPR method for landslide investigations.
Spatial Allocation Rationality Analysis of Medical Resources Based on Multi-Source Data: Case Study of Taiyuan, China
Authors: Hu Lujin , Cai Shengqi
Published: August 2024

Reasonably allocating medical resources can effsectively optimize the utilization efficiency of such resources. This paper took Taiyuan City as an example and established a model to evaluate the rationality of medical resource spatial allocation, incorporating two key dimensions: the spatial layout and the supply and demand of medical resources. In terms of the spatial layout, three indexes were included: Firstly, the service coverage rates of different levels of medical institutions, based on residents’ medical orientations, were calculated using network analysis methods. Secondly, the Huff-2SFCA method was improved to calculate the accessibility of medical resources for four different modes of transportation. Then, the Health Resource Agglomeration Degree (HRAD) and Population Agglomeration Degree (PAD) were used to quantify the equity of medical resources. In terms of the supply and demand of medical resources, one index was included: the supply–demand ratio of medical resources during sudden public health events, which was calculated using the number of beds per thousand people as an indicator. These four indexes were weighted using the entropy weight method to obtain the rationality grade of medical resource spatial allocation in Taiyuan City. The study found that the rationality evaluation level of medical resource allocation in the central urban area of Taiyuan City followed a “concentrically decreasing” pattern. The rating ranged from “very reasonable” to “less reasonable”, with the area of each level expanding gradually. The areas rated within the top two categories only accounted for 19.92% of the study area, while the area rated as “less reasonable” occupied 38.73% of the total area. These results indicate that the model accounted for residents’ travel for various medical orientations and the availability of resources during public health emergencies. It considered both the spatial layout and supply and demand of medical resources, offering recommendations for the precise allocation of urban medical resources.
Determinants Affecting the Awareness of Hypertension Complications within the General Population in Saudi Arabia
Authors: Alharthi Muffarah Hamid , Miskeen Elhadi , Alotaibi Eman Abdullah , Ibrahim Ibrahim Awad Eljack , Alamri Mohannad Mohammad S. , Alshahrani Mohammad S. , Almunif Dina S. , Almulhim Abdullah
Published: August 2024

Background: Hypertension imposes a significant public health burden. An increased awareness of hypertension complications within a population can positively impact patient care and prevent complications. This study seeks to assess the awareness of hypertension complications among the population of Bisha in Saudi Arabia in 2020. Methods: A cross-sectional study was conducted in 2020. A validated self-administered online-based questionnaire was sent to a sample of the adult population of Bisha to measure their awareness of hypertension complications. Results: Almost three-quarters of the population (72.2%) were aware of hypertension complications. The awareness level was significantly higher among male participants (p < 0.001), those aged 31–40 years, those who were married, those working as police officers or in civilian jobs, those living in urban areas (p = 0.04), those with a university-level education (p = 0.03), those with a medium family income (SAR 5000–14,999) (p = 0.001), and those with a history of hospitalization because of causes other than hypertension (p = 0.05). Marital status was independently predictive of awareness (B = 0.851, Wald test = 12.179, p = 0.000) among the respondents. Conclusion: The study concludes that the awareness of hypertension complications among the Bisha population in Saudi Arabia was deemed acceptable. Factors such as marital status, age, gender, a family history of hypertension, the duration of hypertension, and medication adherence positively influenced this awareness and served as predictors of hypertensive awareness. The findings highlight the importance of health authorities in ensuring the widespread awareness of hypertension complications, particularly among hypertensive individuals.
Impact of the COVID-19 Pandemic on the Diagnosis of Malignant Neoplasia of the Bronchus and Lung in the Burgos Region
Authors: Herrero Gustavo Gutiérrez , Núñez-Rodríguez Sandra , Álvarez-Pardo Sergio , Fernández-Solana Jessica , Collazo-Riobó Carla , García-Bustillo Álvaro , Santamaría-Peláez Mirian , González-Bernal Jerónimo J. , González-Santos Josefa
Published: August 2024

Purpose: To retrospectively analyze the impact of the COVID-19 pandemic on the diagnosis, mortality rate, and survival period of malignant bronchial and lung neoplasms in the Burgos region, with the aim of promoting the development of strategies to improve cancer care management during health crises, highlighting the importance of non-pharmacological approaches to mitigate the negative impacts of future pandemics on lung cancer patients. Methods: This retrospective, longitudinal, single-center study was conducted in Burgos from 2019 to 2021. Participants included all patients diagnosed with malignant bronchial and lung neoplasms by the Pneumology unit of Complejo Asistencial Universitario de Burgos during the year immediately before and the year immediately after 31 March 2020, the official start date of the pandemic. Inclusion criteria encompassed patients diagnosed through histological or clinicoradiological methods, who provided informed consent. Data were systematically gathered using a specific template that included demographic information, disease stage, death, and survival time. Statistical analysis involved descriptive methods, ANOVA, and chi-square tests to assess differences in survival time and associations between categorical variables. Results: The results reveal a decrease in the number of patients diagnosed during the pandemic period (154 vs. 105), which could indicate delays in detection. However, there were no significant differences between the two periods, in which more than 60% of cases were detected in stage IV, being incompatible with survival. Although fewer patients died during the pandemic than expected (p = 0.015), patients diagnosed after the onset of the pandemic had a shorter survival time (182.43 ± 142.63 vs. 253.61 ± 224.30; p = 0.038). Specifically, those diagnosed in stage I during the pre-pandemic had a much longer survival time (741.50 days) than the rest of the patients (p < 0.05). In addition, among those diagnosed in stage IV, those diagnosed after the beginning of the pandemic had a shorter survival time (157.29 ± 202.36 vs. 241.18 ± 218.36; p = 0.026). Conclusions: Understanding these changes can support both medical strategies and non-pharmacological therapies to improve cancer care management during health crises, thus contributing to the optimization of public health.
Understanding the Associations between Executive Function and Psychological Variables in Fibromyalgia Syndrome: A Network Analysis Approach
Authors: Pacho-Hernández Juan C. , Fernández-Palacios Francisco G. , Tejera-Alonso Ángela , Fernández-de-las-Peñas César , Varol Umut , Valera-Calero Juan A. , Fernández-Méndez Luis M. , Cigarán-Mendez Margarita
Published: August 2024

The aim of this study was to quantify the multivariate relationships between clinical, cognitive performance, executive functioning, and psychological outcomes in women with fibromyalgia (FMS) using network analyses. Demographic (age, height, weight), clinical (pain history, pain intensity, and related disability), neurocognitive (D2 Attention test, Rey-Osterrieth Complex Figure for visual perception, “Digits D/R/I” tests of the WAIS-IV battery for working memory, the 5-Digit Test for mental inhibition, the Symbol Search for processing speed and the Zoo Test for planning/decision making) and psychological (depressive symptoms, anxiety levels, sleep quality, pain hypervigilance) variables were collected in 129 women with FMS and 111 healthy women. Network analyses were conducted separately for each group to quantify the adjusted correlations between the modeled variables and to assess their centrality indices (i.e., connectivity with other symptoms in the network and their importance in the network). The network identified 74 associations in FMS women and 46 associations in controls with small differences. The strongest correlations in both groups were found between different attention variables: d2_CON with d2_C, d2_O with d_2TR, and d2_CON with d2_TA. The most central variables were d2_TA, d2_C, and d2_CON (highest strength centrality in both groups) and anxiety levels and pain hypervigilance (highest harmonic centrality in FMS women). The strength centrality of the network was stable for women with FMS (CScor0.7: 0.68) but not for healthy women (CScor0.7: 0.28). This study found that attention variables are most relevant within a neurocognitive network and that psychological variables are most important for the treatment of women with FMS. The clinical implications of the current findings, such as the development of treatments targeting these variables, are discussed.
Geriatric Trauma Outcome Score as a Mortality Predictor in Isolated Moderate to Severe Traumatic Brain Injury: A Single-Center Retrospective Study
Authors: Huang Ching-Ya , Yen Yuan-Hao , Tsai Ching-Hua , Hsu Shiun-Yuan , Tsai Po-Lun , Hsieh Ching-Hua
Published: August 2024

Background: Traumatic brain injury (TBI) is a major cause of mortality and disability worldwide, with severe cases significantly increasing the risk of complications and long-term mortality. The Geriatric Trauma Outcome Score (GTOS), based on age, injury severity, and transfusion need, has been validated for predicting mortality in older trauma patients, but its utility in predicting mortality for TBI patients remains unexplored. Methods: This retrospective study included 5543 adult trauma patients with isolated moderate to severe TBI, defined by head Abbreviated Injury Scale (AIS) scores of ≥ 3, from 1998 to 2021. GTOS was calculated with the following formula: age + (Injury Severity Score × 2.5) + 22 (if transfused within 24 h). The area under the receiver operating characteristic curve (AUROC) assessed GTOS’s ability to predict mortality. The optimal GTOS cutoff value was determined using Youden’s index. Mortality rates were compared between high- and low-GTOS groups, separated by the optimal GTOS cutoff value, including a propensity score-matched analysis adjusting for baseline characteristics. Results: Among 5543 patients, mortality was 8.3% (462 deaths). Higher mortality is correlated with male sex, older age, higher GTOS, and comorbidities like hypertension, coronary artery disease, and end-stage renal disease. The optimal GTOS cut-off for mortality prediction was 121.5 (AUC = 0.813). Even when the study population was matched by propensity score, patients with GTOS ≥121.5 had much higher odds of death (odds ratio 2.64, 95% confidence interval 1.93–3.61, p < 0.001) and longer hospital stays (mean 16.7 vs. 12.2 days, p < 0.001) than those with GTOS < 121.5. Conclusions: These findings support the idea that GTOS is a useful tool for risk stratification of in-hospital mortality in isolated moderate to severe TBI patients. However, we encourage further research to refine GTOS for better applicability in TBI patients.
The Contribution of Legionella anisa to Legionella Contamination of Water in the Built Environment
Authors: Crook Brian , Young Charlotte , Rideout Ceri , Smith Duncan
Published: August 2024

Legionella bacteria can proliferate in poorly maintained water systems, posing risks to users. All Legionella species are potentially pathogenic, but Legionella pneumophila (L. pneumophila) is usually the primary focus of testing. However, Legionella anisa (L. anisa) also colonizes water distribution systems, is frequently found with L. pneumophila, and could be a good indicator for increased risk of nosocomial infection. Anonymized data from three commercial Legionella testing laboratories afforded an analysis of 565,750 water samples. The data covered July 2019 to August 2021, including the COVID-19 pandemic. The results confirmed that L. anisa commonly colonizes water distribution systems, being the most frequently identified non-L. pneumophila species. The proportions of L. anisa and L. pneumophila generally remained similar, but increases in L. pneumophila during COVID-19 lockdown suggest static water supplies might favor its growth. Disinfection of hospital water systems was effective, but re-colonization did occur, appearing to favor L. pneumophila; however, L. anisa colony numbers also increased as a proportion of the total. While L. pneumophila remains the main species of concern as a risk to human health, L. anisa’s role should not be underestimated, either as a potential infection risk or as an indicator of the need to intervene to control Legionella’s colonization of water supplies.
Breathing Clean Air: Navigating Indoor Air Purification Techniques and Finding the Ideal Solution
Authors: Alhussain Hashim , Ghani Saud , Eltai Nahla O.
Published: August 2024

The prevalence of airborne pathogens in indoor environments presents significant health risks due to prolonged human occupancy. This review addresses diverse air purification systems to combat airborne pathogens and the factors influencing their efficacy. Indoor aerosols, including bioaerosols, harbor biological contaminants from respiratory emissions, highlighting the need for efficient air disinfection strategies. The COVID-19 pandemic has emphasized the dangers of airborne transmission, highlighting the importance of comprehending how pathogens spread indoors. Various pathogens, from viruses like SARS-CoV-2 to bacteria like Mycobacterium (My) tuberculosis, exploit unique respiratory microenvironments for transmission, necessitating targeted air purification solutions. Air disinfection methods encompass strategies to reduce aerosol concentration and inactivate viable bioaerosols. Techniques like ultraviolet germicidal irradiation (UVGI), photocatalytic oxidation (PCO), filters, and unipolar ion emission are explored for their specific roles in mitigating airborne pathogens. This review examines air purification systems, detailing their operational principles, advantages, and limitations. Moreover, it elucidates key factors influencing system performance. In conclusion, this review aims to provide practical knowledge to professionals involved in indoor air quality management, enabling informed decisions for deploying efficient air purification strategies to safeguard public health in indoor environments.
Examining Spatial Disparities in Electric Vehicle Public Charging Infrastructure Distribution Using a Multidimensional Framework in Nanjing, China
Authors: Wang Moyan , Liang Zhengyuan , Li Zhiming
Published: August 2024

With the increasing demand for electric vehicle public charging infrastructure (EVPCI), optimizing the charging network to ensure equal access is crucial to promote the sustainable development of the electric vehicle market and clean energy. Due to limited urban land space and the large-scale expansion of charging infrastructure, determining where to begin optimization is the first step in improving its layout. This paper uses a multidimensional assessment framework to identify spatial disparities in the distribution of EVPCI in Nanjing Central Districts, China. We construct a scientific evaluation system of the public charging infrastructure (PCI) layout from four spatial indicators: accessibility, availability, convenience, and affordability. Through univariate and bivariate local indicators of spatial autocorrelation (LISA), the spatial agglomeration pattern of the EVPCI service level and its spatial correlation with social factors are revealed. The results of this study not only identify areas in Nanjing where the distribution of PCI is uneven and where there is a shortage but also identify areas down to the community level where there are signs of potential wastage of PCI resources. The results demonstrate that (1) urban planners and policymakers need to expand the focus of PCI construction from the main city to the three sub-cities; (2) it is necessary to increase the deployment of PCI in Nanjing’s old residential communities; and (3) the expansion of PCI in Nanjing must be incremental and optimized in terms of allocation, or else it should be reduced and recycled in areas where there are signs of resource wastage. This study provides targeted and implementable deployment strategies for the optimization of the spatial layout of EVPCI.
Luminescence Efficiency and Spectral Compatibility of Cerium Fluoride (CeF3) Inorganic Scintillator with Various Optical Sensors in the Diagnostic Radiology X-ray Energy Range
Authors: Ntoupis Vasileios , Michail Christos , Kalyvas Nektarios , Bakas Athanasios , Kandarakis Ioannis , Fountos George , Valais Ioannis
Published: August 2024

The aim of this study was to experimentally assess the luminescence efficiency of a cerium fluoride (CeF3) inorganic scintillator in crystal form as a possible alternative to high-luminescence but hygroscopic cerium bromide (CeBr3). The experiments were performed under typical diagnostic radiology X-rays (50–140 kVp). Parameters such as the crystal’s absolute luminescence efficiency (AE) and the spectral matching with a series of optical detectors were examined. The replacement of bromine with fluorine appeared to drastically reduce the AE of CeF3 compared to CeBr3 and other commercially available inorganic scintillators such as bismuth germanate (Bi4Ge3O12-BGO). CeF3 reaches a maximum luminescence efficiency value of only 0.8334 efficiency units (EUs) at 140 kVp, whereas the corresponding values for CeBr3 and BGO were 29.49 and 3.41, respectively. Furthermore, the emission maximum (at around 313 nm) moved towards the lower part of the visible spectrum, making CeF3 suitable for spectral coupling with various photocathodes and photomultipliers applied in nuclear medicine detectors, but completely unsuitable for spectral matching with CCDs and CMOS. The obtained luminescence efficiency results denote that CeF3 cannot be applied in medical imaging applications covering the range 50–140 kVp; however, examination of its luminescence output in the nuclear medicine energy range (~70 to 511 keV) could reveal possible applicability in these modalities.
Heart Rate Variability in Acute Myocardial Infarction: Results of the HeaRt-V-AMI Single-Center Cohort Study
Authors: Brinza Crischentian , Floria Mariana , Scripcariu Dragos-Viorel , Covic Alexandra Maria , Covic Adrian , Popa Iolanda Valentina , Statescu Cristian , Burlacu Alexandru
Published: August 2024

(1) Background: Heart rate variability (HRV) has been investigated in the context of ST-segment elevation myocardial infarction (STEMI). This study contributes to the field by assessing short-term HRV during primary percutaneous coronary intervention (PCI) using wearable technology, providing real-time insights into autonomic function. (2) Methods: This single-center, observational cohort study included 104 STEMI patients undergoing primary percutaneous coronary intervention (PCI). HRV parameters (including SDNN, RMSSD, pNN50, HF, SD1, and SD2/SD1 ratio) were measured using a wearable device (Empatica E4 wristband, CE certified). Measurements were taken throughout the entire duration of the primary PCI, as well as specifically during the initial 5 min and the final 5 min of the procedure. The association between HRV parameters and adverse outcomes, including in-hospital mortality and in-hospital major adverse cardiovascular events (MACE), were assessed. (3) Results: HRV parameters significantly decreased after myocardial revascularization, particularly SDNN, RMSSD, pNN50, HF, SD1, and SD2/SD1 ratio. Significant associations were found between reduced SD2/SD1 ratio, approximate entropy, and adverse outcomes, including increased in-hospital mortality and in-hospital MACE (respectively, p = 0.007, p = 0.017 and p = 0.006 and p = 0.005). The SD2/SD1 ratio was significantly lower in patients who died during the hospital stay (p = 0.008) compared to survivors. Approximate entropy was also significantly lower in deceased patients (p = 0.019). (4) Conclusions: Real-time HRV monitoring using wearable technology offers valuable data regarding dynamic physiological changes during primary PCI. Further studies are required to validate these preliminary results and to explore their potential implications for clinical practice.
Coxsackievirus Group B Infections during Pregnancy: An Updated Literature Review
Authors: Longo Carolina , Saito Mauricio , Castro Pedro Teixeira , Traina Evelyn , Werner Heron , Elito Júnior Julio , Araujo Júnior Edward
Published: August 2024

Coxsackievirus group B (CVB), a member of the Picornaviridae family and enterovirus genus, poses risks during pregnancy due to its potential to cause severe fetal and neonatal infections. Transmission primarily occurs through fecal–oral routes, with infections peaking mostly in warmer months. Vertical transmission to the fetus can lead to conditions such as myocarditis, encephalitis, and systemic neonatal disease, presenting clinically as severe myocardial syndromes and neurological deficits. Diagnostic challenges include detecting asymptomatic maternal infections and conducting in utero assessments using advanced techniques like RT-PCR from amniotic fluid samples. Morbidity and mortality associated with congenital CVB infections are notable, linked to preterm delivery, fetal growth restriction, and potential long-term health impacts such as type 1 diabetes mellitus and structural cardiac anomalies. Current treatments are limited to supportive care, with emerging therapies showing promise but requiring further study for efficacy in utero. Preventive measures focus on infection control and hygiene to mitigate transmission risks, which are crucial especially during pregnancy. Future research should aim to fill knowledge gaps in epidemiology, improve diagnostic capabilities, and develop targeted interventions to enhance maternal and fetal outcomes.
Ultrasound Imaging in Knee Osteoarthritis: Current Role, Recent Advancements, and Future Perspectives
Authors: D’Agostino Valerio , Sorriento Angela , Cafarelli Andrea , Donati Danilo , Papalexis Nicolas , Russo Alessandro , Lisignoli Gina , Ricotti Leonardo , Spinnato Paolo
Published: August 2024

While conventional radiography and MRI have a well-established role in the assessment of patients with knee osteoarthritis, ultrasound is considered a complementary and additional tool. Moreover, the actual usefulness of ultrasound is still a matter of debate in knee osteoarthritis assessment. Despite that, ultrasound offers several advantages and interesting aspects for both current clinical practice and future perspectives. Ultrasound is potentially a helpful tool in the detection of anomalies such as cartilage degradation, osteophytes, and synovitis in cases of knee osteoarthritis. Furthermore, local diagnostic and minimally invasive therapeutic operations pertaining to knee osteoarthritis can be safely guided by real-time ultrasound imaging. We are constantly observing a growing knowledge and awareness among radiologists and other physicians, concerning ultrasound imaging. Ultrasound studies can be extremely useful to track the response to various therapies. For this specific aim, tele-ultrasonography may constitute an easy tool aiding precise and repeated follow-up controls. Moreover, raw radio-frequency data from US backscattering signals contain more information than B-mode imaging. This paves the way for quantitative in-depth analyses of cartilage, bone, and other articular structures. Overall, ultrasound technologies and their rapid evolution have the potential to make a difference at both the research and clinical levels. This narrative review article describes the potential of such technologies and their possible future implications.
Eosinophilic Bronchiectasis: Prevalence, Severity, and Associated Features—A Cohort Study
Authors: Campisi Raffaele , Nolasco Santi , Mancuso Manuel , Spinella Miriam , Vignera Fabio , Crimi Nunzio , Vancheri Carlo , Crimi Claudia
Published: August 2024

Background: Bronchiectasis (BE) has been traditionally associated with neutrophilic inflammation, but eosinophilic bronchiectasis (EB) has recently emerged. Data about prevalence, clinical features, and disease severity are lacking. This study aimed to assess the EB prevalence, compare EB with non-EB, evaluate the Type-2 (T2) high endotype in BE (T2-high EB) versus non-T2-high EB, and identify EB predictors. Methods: We conducted a prospective study involving 153 BE patients. The data collected included clinical, radiological, and microbiological findings. BE severity was assessed using the bronchiectasis severity index (BSI), FACED and E-FACED scores, and the bronchiectasis etiology and comorbidity index (BACI). EB was defined as a blood eosinophil count (BEC) ≥ 300 cells/μL, and T2-high EB as BEC ≥ 300 cells/μL with fractional exhaled nitric oxide (FeNO) ≥ 25 ppb. Results: Prevalence was 27% for EB and 20% for T2-high EB. EB patients exhibited poorer lung function and more severe radiologic features, with significantly higher severity scores [BSI, FACED, E-FACED, BACI (p < 0.05)], and a higher median exacerbation rate [4 (2–5) in EB vs. 2 (1–4) in non-EB, p = 0.0002], compared with non-EB patients. T2-high EB patients showed higher severity scores [BSI, FACED, E-FACED (p < 0.05)], as well as worse lung function parameters [FEV1%, FVC%, FEF 25–75% (p < 0.05)] compared with non-T2-high EB patients. In our study, patients with EB exhibited notably worsened lung function and higher BE severity scores compared with their non-EB counterparts, with exacerbations playing a major role in these differences. We found statistically significant positive correlations between BEC and disease severity scores, such as BSI, FACED, and mMRC, as well as an inverse relationship with pulmonary function. The likelihood of EB being present was significantly higher in association with mMRC ≥ 1 (OR = 2.53; 95% CI, 1.26–5.64), exacerbations/year ≥ 1 (OR = 1.27; 95% CI, 1.0–1.63), and chronic PA colonization (OR = 3.9; 95% CI, 1.08–15.8). Conclusions: EB is a distinct endotype. Dyspnea, exacerbations, and PA colonization may be predictive of EB, emphasizing the importance of early detection for improved outcomes. BEC could serve as a useful biomarker of disease severity to consider when diagnosing EB.
Correction of Post-Surgical Temporal Hollowing with Adipo-Dermal Grafts: A Case Series
Authors: Andreoli Stefano , Brucato Davide , Schmauss Daniel , Harder Yves
Published: August 2024

Background: Surgical dissection and partial detachment of the temporalis muscle during neurosurgical procedures might result in a temporal depression known as “temporal hollowing”. Reconstructive procedures to correct this condition include the implantation of synthetic materials (e.g., hydroxyapatite, methacrylate or polyethylene), injection of autologous fat or fillers as well as the use of flaps (e.g., temporo-parietal local flap and latissimus dorsi free flap). However, none of these techniques proved to be an ideal option due to a high complication rate or need for invasive and complex surgery. Adipo-dermal grafts are autologous; the resorption rate seems to be limited and the complexity of the procedure is minor. Moreover, autologous fat grafting can be performed to enhance the final outcome by correcting residual contour deformities. Methods: In this series of five patients, an institutional experience is presented using multi-layered adipo-dermal grafts harvested from the supra-pubic area for the restoration of volume and contour in post-surgical temporal hollowing. During the last follow-up, patients were asked to express their satisfaction, which was assessed by a survey. Results: this approach demonstrates a marked improvement in temporal hollowing associated with a low complication rate and good patient satisfaction. Conclusions: the aim of this consecutive case series is to emphasize the effectiveness of this surgical technique as one of the options to address temporal hollowing.
Non-Obstructive Azoospermia and Intracytoplasmic Sperm Injection: Unveiling the Chances of Success and Possible Consequences for Offspring
Authors: Majzoub Ahmad , Viana Marina C. , Achermann Arnold P. P. , Ferreira Isadora T. , Laursen Rita J. , Humaidan Peter , Esteves Sandro C.
Published: August 2024

Non-obstructive azoospermia (NOA) is found in up to 15% of infertile men. While several causes for NOA have been identified, the exact etiology remains unknown in many patients. Advances in assisted reproductive technology, including intracytoplasmic sperm injection (ICSI) and testicular sperm retrieval, have provided hope for these patients. This review summarizes the chances of success with ICSI for NOA patients and examines preoperative factors and laboratory techniques associated with positive outcomes. Furthermore, we reviewed possible consequences for offspring by the use of ICSI with testicular sperm retrieved from NOA patients and the interventions that could potentially mitigate risks. Testicular sperm retrieved from NOA patients may exhibit increased chromosomal abnormalities, and although lower fertilization and pregnancy rates are reported in NOA patients compared to other forms of infertility, the available evidence does not suggest a significant increase in miscarriage rate, congenital malformation, or developmental delay in their offspring compared to the offspring of patients with less severe forms of infertility or the offspring of fertile men. However, due to limited data, NOA patients should receive specialized reproductive care and personalized management. Counseling of NOA patients is essential before initiating any fertility enhancement treatment not only to mitigate health risks associated with NOA but also to enhance the chances of successful outcomes and minimize possible risks to the offspring.
Endovascular Embolization of Intracranial Aneurysms Using Target Tetra Detachable Coils: Angiographic and Clinical Results from a Single Center
Authors: Kim Wook , Jee Tae Keun , Yeon Je Young , Kim Keon Ha , Kim Jong-Soo , Jeon Pyoung
Published: August 2024

Background/Objectives: Target tetra detachable coils (TTDCs) aid in achieving effective framing during the coil embolization of small intracranial aneurysms by maintaining a tetrahedral conformation within the aneurysm sac. We aimed to report the initial experience of patients treated for intracranial aneurysms using TTDCs, with a specific focus on efficacy and safety. Methods: We retrospectively reviewed the medical records of 41 patients who underwent the coil embolization of intracranial aneurysms sized ≤10 mm with TTDCs between April and May 2023. Post-procedural angiographic and clinical results were reviewed. Results: Of the 46 aneurysms (45 unruptured and 1 ruptured), 33 (71.7%) were treated with the stent-assisted technique and 13 (28.3%) using the simple coil embolization technique. Post-procedural angiography showed complete occlusion in 41 aneurysms (89.1%), neck remnants in 1 (2.2%), and residual aneurysms in 4 (8.7%). The mean packing density was 34.7% (19.3–46.8%), with TTDC coil length comprising a mean of 88.5% of the total coil length. No major device- or procedure-related complications were observed. During the follow-up, 40 aneurysms (93.0%) demonstrated complete occlusion, while neck remnants were observed in 1 (2.3%), and residual aneurysms in 2 (4.7%). No cases of recanalization were observed. Conclusions: The TTDC is a safe and effective device for the endovascular treatment of intracranial aneurysms. Follow-up studies are required to establish long-term results.
Trajectory Tracking Control for an Underactuated AUV via Nonsingular Fast Terminal Sliding Mode Approach
Authors: Wang Yuan , Du Zhenbin
Published: August 2024

This paper studies the trajectory tracking issue for an underactuated autonomous underwater vehicle (AUV) in the horizontal plane. The desired velocity–tracking error relationship (DVTER) is constructed according to the kinematics and kinetic equation, which means that the expected velocities are built so that the position tracking errors converge to 0. Moreover, the limitation of obtaining the expected velocity by directly differentiating the desired position values is avoided. Then, the nonsingular fast terminal sliding mode (TSM) controller is developed to ensure that the velocities converge to the designed expected values in finite time, and tracking speed is improved by comparing with the traditional nonsingular terminal sliding mode method. It turns out that the expected trajectory can be tracked by an underactuated AUV. Finally, the efficiency of the constructed control mechanism is confirmed by simulation results.
Climate Change and Tidal Hydrodynamics of Guadalquivir Estuary and Doñana Marshes: A Comprehensive Review
Authors: Couto Inês , Picado Ana , Des Marisela , López-Ruiz Alejandro , Díez-Minguito Manuel , Díaz-Delgado Ricardo , Bastos Rita , Dias João Miguel
Published: August 2024

The Doñana Protected Area, Western Europe’s largest protected wetland and UNESCO World Heritage Site, is of great importance for the Spanish biodiversity. Despite its ecological value, there is a noticeable scarcity of scientific and technical information about its hydrology and expected climate change effects, as highlighted by several authors. This article reviews the existing research on the Guadalquivir River and Doñana National Park, examining the interplay between hydrodynamics, climate change scenarios, and the potential impact of the removal of the current dike which was built to limit tidal flooding. In this context, the hydrodynamic changes predicted by a hydrodynamic model were examined under both present (including the current mean sea level and the presence of the dike) and predicted future conditions (encompassing a mean sea level rise of 0.84 m and the removal of the dike). These hydrodynamic changes were assessed in terms of the maximum predicted water levels, mean velocity, amplitude, and phase of M2 and M4 tidal constituents, tidal asymmetry, and tidal prims. The results reveal that the removal of the dike and a sea level rise will have a significant impact on the protected area, resulting in the complete flooding of the Doñana national marshes during spring tides. Such changes could have negative impacts, as increased environmental alterations would require more demanding adaptation measures.