bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the relationship between monetary rewards and flexible work schedule on intention to stay in ICT companies
Authors: Mohd Zin Md Lazim , Pangil Faizuniah , Othman Siti Zubaidah
Published: January 2023

Retaining existing employees, especially the skilled information technology (IT) employees is becoming more important due to business growth, imbalance between demand and supply, and high turnover rate. The paper seeks to investigate the relationship between rewards and flexible work schedule on intention to stay among professional IT employees. The two factors investigated in this study are monetary rewards (salary and bonus) and flexible work schedule. Results from 178 participants indicate that both monetary rewards (salary and bonus) and flexible work schedule were significantly positively related to intention to stay. Though salary, bonus and flexible work schedule indicate significant positive relationship with intention to stay, salary makes the strongest contribution to intention to stay. Implications of the findings, potential limitations of the study, and directions for future research are suggested.
Examining the corporate competitive capabilities of Malaysian manufacturing SMEs
Authors: Zulkiffli Siti Nur â€˜Atikah , Perera Nelson
Published: January 2023

The purpose of this paper is to examine the relationship between corporate competitive capabilities, which consists of cost leadership, differentiation, innovative marketing and customer service; and business performance. The paper is a quantitative-based approach using data obtained from the manufacturing sector of small to medium enterprises in Malaysia. Empirical results from structural equation modeling (SEM) demonstrate that corporate competitive capabilities had significant influence on its business performance. The paper has limitations due to a small response rate, would show short of a firmer conclusion from the analysis. This paper will contribute to the literature on strategic management, SMEs and resource-based view theory. This study is particularly new in the context of the Malaysian SMEs manufacturing industry. The findings provide useful guidance to Malaysian SMESâ€™ practitioners and policy-makers, by understanding the unique capabilities of their firms.
The influence of industry affiliation on corporate tax avoidance in Malaysia
Authors: Ariffin Zaimah Zainol
Published: January 2023

Prior studies on tax avoidance have been emphasising on the individuals behaviour rather than corporations. In addition to this, the available studies on corporate tax avoidance, to date, have been focusing on the developed market while very little attention has been given to the developing countries. Thus, this study attempts to investigate the corporate tax avoidance behaviour in Malaysia, focusing on industry affiliations. Specifically, the objective of this study is to examine the importance of industry affiliations as possible contributions of corporate tax avoidance mechanism. This study documented the link between industry affiliations and corporate tax avoidance in an emerging market. This study tested the relationship by using a crosssectional-time series valuation using panel data analyses, which is Tobit estimations. The results confirmed the importance of industry differences in explaining corporate tax avoidance activity. As more data become available in the future, one could include tax avoidance study in non-listed companies.
Group farming and productivity in the Muda Agricultural Development Authority of Malaysia
Authors: Ali Jamal , Kamaruddin Roslina , Mohd Saad Nariman
Published: January 2023

The paddy sector is a strategic sector in Malaysia. This is due to its importance in the context of rice self-sufficiency, income generation and job opportunities especially for the rural population. The Malaysian government has set the goal of achieving self- sufficiency level in rice production at about 65-70% of local consumption. In order to achieve the objective, the government has implemented many strategies, the group farming project in Muda Agricultural Development Area (MADA) is one such strategy. The study was conducted on four MADA areas representing three schemes, namely the 10 tones Project, Estate Paddy Project, and Model Farm Project. The proportionate multistage stratified random sampling technique involving the area sampling method and the systematic method was employed to select 664 respondents. An econometric model and other statistical techniques were used to estimate the effects of group farming project on productivity and farmersâ€™ income. The study shows that, in terms of economic return dimension, Model Farm Project is more successful in increasing the paddy production. The study makes a number of suggestions for improving the effectiveness of group farming projects. Recommendations are included in the project planning and implementation of group farming, and the importance of subsidy on paddy production for farmers in the study area.
Efforts and challenges in adopting international financial reporting standards (IFRS) in Nigeria
Authors: Alkali Muhammad Yusuf , Lode Nor Asma
Published: January 2023

Financial reporting in emerging and developed economies has been a challenging

debate, due to the frequent changes as well as updates on accounting rules and

regulations. Nigeria, being an emerging economy has witnessed a dramatic change

and improvement on the accounting reporting since after political development of

the country in 1960. The establishment of Nigerian Security Exchange (NSE) in 1982

and the establishment of Nigerian Accounting Standard Board (NASB) in 1984 by the

Institute

of Chartered Accounting of Nigeria (ICAN) who were the pioneer legislations

on the road map to financial reporting in Nigeria. Even though laws and regulations

were also issued by the regulatory bodies in Nigeria to ensure quality(value relevance)

financia

l reporting, the level of compliance with the regulations have been very low

as reported by the World Bank in the 2004 and 2011(ROSC report). Subsequently,

professionals, regulatory bodies and government made the first effort by establishing

the road map a

nd the World Bank committee for the adoption of the International

Financial Reporting Standards (IFRS) in 2010. Secondly, the formation of the Financial

Reporting Council (FRC) in 2011 and FRC training institute in 2012. However, these

efforts by the gover

nment, World Bank and regulators were faced with the challenges on

the development of regulatory and legal framework as well as training of professionals

and regulators on the new accounting standard (IFRS). Therefore, this paper explores

two main issues:

(i) the efforts of government, professional bodies, and regulatory

agencies by providing accounting framework and trainings; and (ii) challenges in

adopting IFRS due to weaknesses of SAS and unethical behaviours of the preparers of

financial statements.
Takaful as a risk management tool in Islamic estate planning
Authors: Azhar Alias , Che Arshad Noraziah
Published: January 2023

Takaful is a form of protection to help us, our family and our beloved person. A good Muslim must be a Muslim with a forward thinking. Hence, some continuity preparation must be done and this preparation must take place from now, in future and in fact after death. To accomplish this goal, wealth management has been determined as an important tool as it plays some important roles to assist for a proper planning in our life and after our death. In other word, Islamic wealth management aims to provide the best reward in this world and hereafter. Furthermore, it has been strengthened by Islamic law that has outlined a comprehensive guidance related to property management after death through a complete and systematic Islamic estate. The benefits can be enjoyed by family from takaful products and will be the Islamic estate of a continuity guarantee after the contributor passes away. Aspired by this issue, this paper focuses on two fold. The first fold discusses on takaful products in Islamic estate planning and followed by the second fold that elaborates on how to incorporate this instrument to be more integrated in Islamic financial system in particular and Islamic economics system in general. The discussions encompasses on shariah aspects and further the applications of this product in Malaysia.
Adoption and Use of E-Procurement: A Case Study in HM Sdn. Bhd.
Authors: Ibrahim Marhaiza
Published: January 2023

The adoption and usage rate of electronic-procurement (eP) in Malaysia has been relatively slow since the beginning of eP implementation. This highlights the need to understand the inhibitor factors of eP adoption and usage among suppliers in Malaysia. This study examined the adoption and use of eP by the HM Sdn. Bhd. construction company (HM), and its contribution to the Management Information System (MIS) planning strategy in the organisation. An in-depth case study approach was employed in this study. The respondents consisted of 21 individuals from middle and top management levels of HM using purposive sampling procedure. The data were collected via interview and analysed using narrative analysis method. The finding of this study highlighted that complexity and compatibility are the key inhibitor factors in the adoption and use of eP among middle management and top management in the company. Failure to maximise eP advantages can reduce the competitiveness of HM in the market. Furthermore, the management had spent a huge investment to make the eP system become reality.
The Impact of Product Cues and Brand Attitude towards Purchase Intention of Automobiles
Authors: Hashim Noor Azmi , Mohammad Osman , Haron Mahmod Sabri
Published: January 2023

The varying characteristics reflective of the actual diversity in how intentions areconducted have found that intentions are significantly better predictors of purchasebehavior for existing products and durable than for non-durable products. Theseresults are remarkable because, in practice, intentions are often used to predict salesfor new non-durable products, and they are better predictors of behaviors over ashort horizon. Branding is also important because it communicates a brandâ€™s businessproposition. The most successful visual expression of a brand is its core attributes,and a positive emotional relationship between the brand and its audience needs to beestablished. Building a local, regional, or national brand with a clearly defined andunderstood target audience is difficult and even more difficult when a global brand isat stake. Some global brands are strongly associated with their country of origin. Incertain categories, this is part of the essence of the brand. Automobiles are the mostnotable example. The objective of this study is to understand the variables influencingconsumersâ€™ purchase intention related to automobiles. In particular, this study providesinsight into the perception of Malaysian consumers with regards to their purchaseintention of a certain brand of automobiles.
Factors Associated with Employeesâ€™ Choice of Mandatory Retirement Plan: The Case of Malaysian Public Universities
Authors: Tolos Habibah , Abu Bakar Arpah , Owolabi Yusuf Muhammad Bashir
Published: January 2023

This study examines the factors that influence public sector employees in making adecision to enroll in either one of the two types of mandatory retirement plans. A surveyof 348 Malaysian public universities employees was conducted, and the data obtainedwere analyzed using a logistic regression model. The results show that knowledge, planfeature, sources of retirement income, health status, job mobility, and extending workare the contributing factors of the choice of the retirement plan. Apart from extendingthe extant literature on retirement plan, this study provides further understanding ofthe employeesâ€™ retirement decision in a different scenario of retirement systems.
Research and Development Evaluation Remodelling in Malaysia: An Idealistic Framework
Authors: Osman Nor Hasni , Allumi Nura Abu Bakar
Published: January 2023

This paper provides an idealistic conceptual framework for Research & Development(R&D) evaluation. R&D is very important in higher level decision making. In Malaysia,though the spending is on increasing term, only a small proportionate of Gross DomesticProduct (GDP) is allocated to fund R&D as compared to the required tasks in the vastfields of research. A lot of efforts were spent in R&D, the undertakings of which shouldbe monitored and well-funded to ensure the results of the research are consideredin making decisions that could be shared, implemented, improvised, and evaluated.Public research which focuses more on educational know-how in the developmentof human resource/human capital could be assimilated in R&D of private sectorswhich focus more on scientific, technology, material handling, and information andcommunication technology (ICT). The more advances occur in science and technologyfields, the demand for manpower in the related fields would increase. In spite of this,any improvement from the implemented research result could not be assured even withfunctional R&D systems if there is no constant evaluation and post decision valuation.The collaboration of public-private R&D institutions would generate a new breedof innovative entrepreneurs that could assist Malaysia to achieve developed nationstatus as set out in Vision 2020. The outcome of this paper is a proposed model ofthe Malaysian R&D evaluation in public agencies, private sectors, and universities toconstruct an idealistic R&D decision evaluation framework for future application. Themodel presents the interconnected interactions that take place within the stakeholderscircle in R&D network. Basically, the model is drawn up under the principle thatvirtually there are balanced interactions and the interested parties are inter-related.
Keberkesanan Organisasi dalam Penyampaian Perkhidmatan: Penilaian Berdasarkan Paradigma Servqual dan Model Kano
Authors: Abu Noor Hidayah , Othman Abdul Aziz , Abidin Rahimi , Mansor Mohd Fitri
Published: January 2023

Departments under the government sector needs to offer the best quality service to meet the needs and requirements of customers. At the same time, the departments should ensure that service delivery to the customer is always relevant from time to time in line with Malaysia government policies, changes in technology, economic development and the dynamics of consumer preferences. The main objective of this study are to measure the quality of service delivery by Department MG using paradigma SERVQUAL and to measure customer satisfaction against the services offered using the Kano Model. Based on paradigma of SREVQUAL, the findings show 20 items out of 21 items that are measured situated in very strong position. Based on Kano model, the findings also shows the level of customer satisfaction are at 79-75% per cent. This indicates MG Department has successfully met the needs and requirements of its customers. But to remain competitive in the services market, MG Department needs to improve the items that are rated below 75%. The results obtained will help improve the performance of the Department MG in offering services to its customers. It is in line with government policy, namely people first, performance now. In fact, the results can be used as a guide in the development of policy and strategy of departments under government sector.
Proton versus Rover: A Business History Approach
Authors: Sharif Mohmad Yazam
Published: January 2023

The objective of this paper is to present some comparative findings on Proton, a carmanufacturer in Malaysia and Rover Group, a British automobile manufacturer. Thepaper used a â€˜Business Historyâ€™ methodology tracking the exploits of the two firmsfrom 1980 to 2000. Two in-depth interviews were conducted with two key informantsâ€“ Nadzmi Salleh, former CEO of Proton and John Towers, the former CEO of RoverGroup. Apart from that, the study also utilized secondary documents from varioussources such British Aerospace and Honda Swindon. Proton and Rover are sources ofnational pride for Malaysia and England respectively. Yet their financial performanceover time were said to be poor. Some efforts by the respective governments and themanagement of the two firms to improve the performance in both firms were highlighted.In terms of the current status of both firms, Proton is still surviving but Rover has beendefunct since 2005.
The Adoption of Lean Principles to Reduce Resistance to Change in Transforming a Shipyard
Authors: Yushak Mohamed Shamaun , Dollah Rozzeta , Abu Bakar Nooh
Published: January 2023

A Shipyard is trying to change, but facing employee Resistance to Change (RTC).Resistance is attributed to the dysfunctional organisational context in the form oftechnical and political/structural issues giving rise to non-conformance behaviour.An action research was conducted with the author as a participant researcher tounderstand and identify the underlying behaviour of the employees. Lean productionwas used as an intervention to re-couple tasks to behavioural elements. Resistance isdue to incoherency of a personâ€™s belief in established standards, giving rise to cognitivedissonance. Lean principles reduces dissonance, creating psychological flow in theworkforce and the momentum for change. As a result, the shipyard managed to recoveredthe delay of a ship and delivered it on-time, with cost avoidance of RM63 million inliquidated damage. The Shipyard also managed to reduce the average delay for shipsundergoing repair to 6 months, compared to previous average delay of 17 months. Thisresearch was a collaboration between the employees and the researcher to identify thesource of RTC. The outcome is both, insightful in creating change and contributionto knowledge. The significance of this study is the realisation of how individuals andgroupsâ€™ past behaviour can subconsciously challenge the existence of the organisationand better methods. The study provides an exploratory model on the workings of humanbehavioural elements in Lean production. The knowledge of how the researcher gainedutility from resistance and mediate through the application of these techniques wouldbe of considerable benefit to leaders of change management.
The Adoption of Cash-basis IPSAS: A Conceptual Framework for Enhancing Decision-Useful Financial Reporting
Authors: Mustapha Maruf , Ku Ismail Ku Nor Izah , Ahmad Halimah Nasibah
Published: January 2023

Reforms in the public sector, the world over, has taken a global dimension towards harmonization and convergence of international and national accounting systems for the promotion of useful and standardized financial reporting practices. At the centre of this change is the adoption and application of the international public sector accounting standards (IPSAS) by public sector entities. The cash-basis IPSAS is one of the IPSAS which supports the presentation of the general purpose financial statement (GPFS) for new adopters that intend to migrate to full accrual-based IPSAS. However, despite its essence as a de facto standard mostly adopted by developing countries, limited studies have considered the consideration for its decision-usefulness for financial reporting. The objective of this paper is to propose a conceptual framework that explains the factors of how financial reporting, based on the cash-basis IPSAS, would assist decision usefulness of financial reports to diverse user groups. In addition, the paper identifies potential organizational factors that may strengthen the elaboration of useful financial reporting statement. Based on the literature survey methodology, this paper argues that, identification of usable format that increases understandability of the financial statements for different user groups and an increased support for accounting staff competency, are veritable considerations in the framework for decision useful financial reporting statement in the application of the cash-basis IPSAS.
Financial Ratio Analysis: Decision Usefulness for Potential Shareholdersâ€™ Benefit
Authors: Kabir Musa Usman , Aripin Norhani , Al-Dhamari Redhwan Ahmed Ali
Published: January 2023

The certainty of the reliance on the use of financial ratio analysis in making investment decisions by potential investors still remained a mystery. This has to do with the choice of ratios to select when making investment decisions. Many shareholders in Nigeria are uneducated or illiterate, and due to their ignorance, they cannot use ratio analysis in evaluating firms for investment decisions. Thus, this paper explores the concept of financial ratio analysis in terms of the decision usefulness of financial ratios. The paper suggests that the relevant financial information needed for the purposes of making investment decision can be sourced through the use of financial ratio analysis. Therefore, management must ensure that disclosure of comprehensive financial ratios form part of financial statement prepared for the overall appraisal of firms.
Determinants of Productivity: A Conceptual Review of Economic and Social Factors
Authors: Danlami Ibrahim Abdulhamid , Hidthiir Mohammad Helmi , Hassan Sallahuddin
Published: January 2023

Welfare improvement is always a key and one of the major objectives of many nations. One of the most important ways of improving societal welfare is through productivity improvements hence various studies have been conducted in relation to this topic. in addition to the current developments in this area of research, this paper attempts to provide in-depth review of previous studies on the determinants of productivity with the aim of identifying both economic and social factors that affect the level of productivity. The paper shows that previous studies on the determinants of productivity are of different folds (on a different basis). The basis of the previous studies includes â€“ that of economic factors and social factors â€“that of statistical method of analysis and non-statistical method of analysis, some studies are based on tangible â€œgoodsâ€ while some are based on intangible â€œservicesâ€, some factors influence productivity positively while some negatively. Even though, the positive and negative effects of some variables are recognized to be non-mutually exclusive as the same variable might have both positive and negative influence on productivity in two different studies or countries due to the existence of discrepancy of some socio-economic conditions, technological strength and factor intensity among countries, areas of studies and organizations. Also, few studies exist on the determinant of productivity in the service sector compared with those in the goods sector. This paper suggests more empirical studies to be conducted in different countries, organizations and areas of studies especially, on the service sector productivity, as generalizations without empirical studies could be inconclusive and the effects of the determinants may be understated or overstated.
Factors Influencing Touristâ€™s Satisfaction based on Service Attributes of Hotels: A Study on Coxâ€™s Bazar, Bangladesh
Authors: Mawa Jannatul
Published: January 2023

This study attempts to identify hotels service attributes that influence touristsâ€™ satisfaction in the context of Coxâ€™s Bazar, Bangladesh. Descriptive research was conducted to gain an insight into the topic and to investigate the factors. This paper reports findings based on a descriptive study. To conduct this study, a survey was administered to 300 respondents using a non-probability sampling which is a convenience sampling technique. To analyze the data, factor analysis, correlation, regression analysis and frequency distribution table was used. A conceptual model of touristâ€™s satisfaction based on service attributes of hotels in Coxâ€™s Bazar was proposed based on factor and regression analysis. Seven factors emerged and were used as independent variables in the regression analysis. Findings indicate that some hotel service attributes have a direct influence on touristsâ€™ satisfaction which make them loyal in the context of Coxâ€™s Bazar.
Assessment of Potential Non-Tax Revenue in Malaysian Local Authorities
Authors: Berahim Nur , Jaafar Mohd Nadzri , Zainudin Ainur Zaireen
Published: January 2023

Non-tax revenue trends and their potential have received less attention than propertytax, which is the primary source for most Malaysian local authorities (LAs). This paperhighlights the examination conducted on potentials and strategies adopted by eachLA investigated to maximize return from non-tax revenue. In doing this, qualitativeapproach using secondary data acquired from financial reports and primary data fromin-depth interviews was employed. Ten LAs were selected through purposive sampling.The trend of revenue collection among the selected LAs and the strategies to improvenon-tax revenue collection through thematic analysis are highlighted. The analysisof the trend of local authoritiesâ€™ revenue reveals that non-tax revenue remains thesecond most important after the tax revenue. However, Pulau Pinang City Council(MBPP) is the only LA that records an average of non-tax revenue exceeding 50 percent of its total internal revenue. This study has also found that the divergence amongthe local authoritiesâ€™ non-tax revenue collection is due to the revenue improvementstrategies adopted by each local authority. Therefore, eight recommendations aremade to improve non-tax revenue. Though this study is limited to 10 LAs as sample, thesuccessful optimizing strategies highlighted from the study can represent an efficientmodel for other LAs, in improving their non-tax collection.
Vac14 protein multimerization is a prerequisite step for Fab1 protein complex assembly and function
Authors: Alghamdi Tamadher A. , Ho Cheuk Y , Mrakovic Amra , Taylor Danielle , Mao Daniel , Botelho Roberto
Published: January 2023

Phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) helps control various endolysosome functions including organelle morphology, membrane recycling, and ion transport. Further highlighting its importance, PtdIns(3,5)P2 misregulation leads to the development of neurodegenerative diseases like Charcot-Marie-Tooth disease. The Fab1/PIKfyve lipid kinase phosphorylates PtdIns(3)P into PtdIns(3,5)P2 whereas the Fig4/Sac3 lipid phosphatase antagonizes this reaction. Interestingly, Fab1 and Fig4 form a common protein complex that coordinates synthesis and degradation of PtdIns(3,5)P2 by a poorly understood process. Assembly of the Fab1 complex requires Vac14/ArPIKfyve, a multimeric scaffolding adaptor protein that coordinates synthesis and turnover of PtdIns(3,5)P2. However, the properties and function of Vac14 multimerization remain mostly uncharacterized. Here we identify several conserved C-terminal motifs on Vac14 required for self-interaction and provide evidence that Vac14 likely forms a dimer. We also show that monomeric Vac14 mutants do not support interaction with Fab1 or Fig4, suggesting that Vac14 multimerization is likely the first molecular event in the assembly of the Fab1 complex. Finally, we show that cells expressing monomeric Vac14 mutants have enlarged vacuoles that do not fragment after hyperosmotic shock, which indicates that PtdIns(3,5)P2 levels are greatly abated. Therefore, our observations support an essential role for the Vac14 homocomplex in controlling PtdIns(3,5)P2 levels.

 
Radiolabeling and Quantification of Cellular Levels of Phosphoinositides by High Performance Liquid Chromatography-coupled Flow Scintillation
Authors: Ho Cheuk Y , Choy Christopher H , Botelho Roberto
Published: January 2023

Phosphoinositides (PtdInsPs) are essential signaling lipids responsible for recruiting specific effectors and conferring organelles with molecular identity and function. Each of the seven PtdInsPs varies in their distribution and abundance, which are tightly regulated by specific kinases and phosphatases. The abundance of PtdInsPs can change abruptly in response to various signaling events or disturbance of the regulatory machinery. To understand how these events lead to changes in the amount of PtdInsPs and their resulting impact, it is important to quantify PtdInsP levels before and after a signaling event or between control and abnormal conditions. However, due to their low abundance and similarity, quantifying the relative amounts of each PtdInsP can be challenging. This article describes a method for quantifying PtdInsP levels by metabolically labeling cells with H-3-myo-inositol, which is incorporated into PtdInsPs. Phospholipids are then precipitated and deacylated. The resulting soluble H-3-glycero-inositides are further extracted, separated by high-performance liquid chromatography (HPLC), and detected by flow scintillation. The labeling and processing of yeast samples is described in detail, as well as the instrumental setup for the HPLC and flow scintillator. Despite losing structural information regarding acyl chain content, this method is sensitive and can be optimized to concurrently quantify all seven PtdInsPs in cells. 
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition
Authors: Saffi Golam T. , Tang Evan , Mamand Sami , Inpanathan Subothan , Fountain Aaron , Salmena Leonardo , Botelho Roberto
Published: January 2023

Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates. Thus, conditions that favour fusion over fission can reduce lysosome numbers while enlarging their size. Conversely, favouring fission over fusion may cause lysosome fragmentation and increase their numbers. PIKfyve is a phosphoinositide kinase that generates phosphatidylinositol-3,5-bisphosphate to modulate lysosomal functions. PIKfyve inhibition causes an increase in lysosome size and reduction in lysosome number, consistent with lysosome coalescence. This is thought to proceed through reduced lysosome reformation and/or fission after fusion with endosomes or other lysosomes. Previously, we observed that photo-damage during live-cell imaging prevented lysosome coalescence during PIKfyve inhibition. Thus, we postulated that lysosome fusion and/or fission dynamics are affected by reactive oxygen species (ROS). Here, we show that ROS generated by various independent mechanisms all impaired lysosome coalescence during PIKfyve inhibition and promoted lysosome fragmentation during PIKfyve re-activation. However, depending on the ROS species or mode of production, lysosome dynamics were affected distinctly. H2O2 impaired lysosome motility and reduced lysosome fusion with phagosomes, suggesting that H2O2 reduces lysosome fusogenecity. In comparison, inhibitors of oxidative phosphorylation, thiol groups, glutathione, or thioredoxin, did not impair lysosome motility but instead promoted clearance of actin puncta on lysosomes formed during PIKfyve inhibition. Additionally, actin depolymerizing agents prevented lysosome coalescence during PIKfyve inhibition. Thus, we discovered that ROS can generally prevent lysosome coalescence during PIKfyve inhibition using distinct mechanisms depending on the type of ROS.

 
The Tradition of Mokhatamu Quru`ani for The Bride In The Marriage Customs (Study of Living Quran in Bongo Village, Batudaa Pantai District Gorontalo)
Authors: Suna Arman , Hairul Moh. Azwar
Published: January 2023

This article discusses the practice of Mokhotamu Quru'ani for the bride in the Gorontalo Community Wedding Procession in Bongo Village, Batudaa Pantai District Gorontalo. The focus of this article is how the participants interpret the tradition reading of the Quran for the bride. To get the social meaning of this tradition, this research uses the Bronislaw Malinowski functionalism approach as a reference and data analysis. The results of this study concluded that Mokhotamu Quru'ani began since the acceptance of Islam as a religion and was integrated with local customs. The implementation of Mokhotamu Quru'ani is practiced with local culture which is based normatively through the philosophy of Adati Hula-Hulaa To Saraa, Saraa Hula-Hulaa to Quru'ani. In the practice the bride reads the Qur’an starts from Q.S. Ad-Duha to An-Nas and Ad-Dhuha. Mokhotamu Qurua'ni has a religious function as a guarantee of peace and happiness of marriage life. Based on the theory of functionalism, the tradition of Mokhotamu Quru'ani fulfil biological need, interumental needs and integrative needs.
Antioxidant, Anti-inflammatory, Antimicrobial and Thrombolytic Activities of Eclipta alba L. Growing in Bangladesh
Authors: Barua Aruna , Kuddus Md Ruhul , Chowdhury M Mohi Uddin , Rashid Mohammad A , Ibrahim Mohammed
Published: January 2023

Eclipta alba L. (Family: Asteraceae) is an evergreen herb of ethnomedicinal significance in the Indian subcontinent. The present study was carried out to determine the in vitro antioxidant, anti-inflammatory, antimicrobial and thrombolytic activities of n-hexane, chloroform and aqueous soluble fractions of ethanol crude extract of E. alba whole plant. Preliminary phytochemical screening was performed by qualitative tests which revealed the presence of alkaloids, steroids, glycosides, tannins, flavonoids, saponins and amides in E. alba. During the DPPH (2,2-diphenyl-1-picrylhydrazyl) scavenging assay, the aqueous soluble fraction of E. alba at a dose of 100 μg/ml showed maximum 87.5% inhibition in scavenging the DPPH radical with IC50 value of 7.86 μg/ml. Anti-inflammatory activity was evaluated by egg albumin denaturation technique and RBC membrane stabilizing method. In both experiments, all the test samples of E. alba showed a concentration-dependent anti-inflammatory potential while the aqueous soluble fraction at the dose of 500 μg/ml demonstrated the maximum 90.12% inhibition of egg albumin denaturation and 78.42% inhibition of RBC membrane hemolysis against hypotonic solution. Antimicrobial sensitivity was evaluated by disc diffusion assay against several bacterial and fungal species. All the test samples at a concentration of 500 μg/disc exhibited noticeable antibacterial (zone of inhibition = 11-23 mm) and antifungal (zone of inhibition = 10-21 mm) activities when compared to the respective standard drug. The aqueous soluble fraction showed maximum activity against Lactobacillus casai (zone of inhibition = 23 mm). During antifungal test, the maximum activity was exhibited by the n-hexane fraction against Pityrosporum ovale (zone of inhibition = 21 mm). During in vitro thrombolytic assay, the aqueous soluble fraction revealed 56.84% lysis of blood clot, as compared to the standard streptokinase (84.60%). The results of our study suggest that E. alba can be considered for further investigation in order to discover the pharmacologically active natural products.
Bangladesh Pharmaceutical Journal 26(1): 20-27, 2023 (January)
In vitro Antioxidant, Thrombolytic and Membrane Stabilizing Activities of the Rourea minor Leaves
Authors: Ferdous Jannatul , Islam Mohammad Ashraful , Kabir Zihad S M Neamul , Karim Tipu Md Fazlul , Kabir Md Alamgir , Adon Md Mobinul Haque , Gosh Jyotimoi , Chowdhury Jakir Ahmed
Published: January 2023

Rourea minor is a species which belongs to the family Connaraceae. Rourea minor reported previously for antibiotic, antibacterial, hemostatic and wound-healing activities. In this study, we evaluated the antioxidant, thrombolytic and membrane stabilizing activities of the crude methanolic extract of the leaves of Rourea minor and its different organic soluble fractions. We measured the total phenolic contents and 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical scavenging activity of the extracts to observe their antioxidant potential. The thrombolytic activity was determined by human blood clot lysis. Anti-inflammatory activity was evaluated by human red blood cell (HRBC) membrane stabilization based on hypotonic solution- and heat-induced haemolysis. The total phenolic content ranged from 9.4 to 57.4 mg GAE/g of the dry extracts and IC50 values of the different extracts (Crude methanol, petroleum ether, ethyl acetate and aqueous) were between 20.38 and 269.34 μg/ml. All the extracts showed mild to moderate thrombolytic potential inhibiting the lysis of clot by 3.47% - 18.43%. The extracts also exhibited potential membrane stabilizing activity in both hypotonic solution- and heatinduced haemolysis indicating their anti-inflammatory activity. Thus, it can be concluded that the methanolic extract from the leaves of Rourea minor and its different fractions possess mild to moderate antioxidant, thrombolytic activities, and membrane stabilizing potential.
Bangladesh Pharmaceutical Journal 26(1): 51-55, 2023 (January)
In vitro and in vivo Pharmacological Studies of Leaves of Staurogyne argentea Wall.
Authors: Chowdhury Suhana Manzur , Sultana Irin , Kuddus Md Ruhul , Ibrahim Mohammed
Published: January 2023

Staurogyne argentea Wall. (Family: Acanthaceae) is an important medicinal plant that has many traditional uses in tribal areas of Bangladesh. The current study emphasizes the pharmacological investigations of n-hexane, chloroform and aqueous soluble fractions of ethanol extract of leaves of S. argentea to justify the traditional uses of this plant species in Bangladesh. In vitro anti-inflammatory activity of S. argentea was confirmed by inhibition of egg albumin denaturation and erythrocyte membrane stabilizing methods. In both experiments, the aqueous fraction at concentration of 160 μg/ml exhibited significant inhibition of egg albumin denaturation by 76.91% with IC50 value of 24.22 μg/ml compared to standard Diclofenac-Na. In membrane stabilization assay, the aqueous fraction showed prominent anti-inflammatory activity by protecting the human erythrocyte membrane against hypotonic solution induced lysis. In addition, among all the aqueous fraction at 100 μg/ml also showed maximum antioxidant potential via the inhibition of DPPH scavenging by 75.05% (IC50= 42.92 μg/ml). The test materials were subjected to evaluate for the anti-diabetic activity by both in vitro starch iodine method as well as by oral glucose tolerance test in Swiss albino mice. In both experiments, the aqueous fraction showed maximum blood glucose lowering activity which is comparable to standard glibenclamide. The chloroform fraction (Conc. 500 mg/kg bw) exhibited moderate inhibition of both acetic acid-induced writhing reflex and yeast-induced pyrexia in mice. During sedative activity screening, different solvent fractions produced mild to moderate activity in comparison with standard diazepam. These findings revealed that S. argentea is a valuable source of bioactive compounds with diverge pharmacological actions, which validates its use in Bangladesh folk medicinal practices.
Bangladesh Pharmaceutical Journal 26(1): 89-98, 2023 (January)
Tú eres importante
Authors:   Universidad del Azuay, Cobos-Cali Martha , Cabrera-Vélez Marcela ,   Universidad del Azuay, Cañizarez-Abril Andrea ,   Universidad del Azuay, Coello-Nieto Fernanda ,   Universidad del Azuay, Polo-Martínez Maribel ,   Universidad del Azuay, Peña-Contreras Eva ,   Universidad del Azuay, Regalado-Villa Linga ,   Universidad del Azuay
Published: January 2023

Tu eres importante constituye una obra que busca fomentar buenas maneras de convivencia escolar, por ello se ha profuncizado en la temática del bulling. Incluye una visión general sobre adolescencia y un análisis de la situación del bulling a nivel mundial y del ecuador; además aporta con la intervención en adolescentes víctimas y en quiénes cometen bulling; y finaliza con un estudio que analiza la importancia de la personalidad de los padres en la formación de las víctimas o en quiénes cometen bulling. Con estos aportes se espera concienciar la necesidad de trabajar en esta problemática desde un modelo que integre a todos los involucrados: víctimas, ejecutores del bulling, observadores, familia, escuela y amigos. 98 páginas ISBN: 978-9978-325-58-2 e-ISBN:978-9978-325-65-0
Representación gráfica 1
Authors:   Universidad del Azuay, Larriva-Rivera Álvaro
Published: January 2023

Las prácticas que se exponen en el texto provienen de las experiencias conseguidas en los cursos académicos de las carreras de diseño, en las cuales se propone una secuencia del manejo de los principios de la Geometría y de la Descriptiva con tareas en las que, a la vez, se revisan las normas del trazado aplicado, sobre todo, en forma manual y con el apoyo de herramientas convencionales: como el tablero de dibujo, el microminas, el compás de precisión, los lápices de color, los marcadores de punta numerada, el escalímetro, las plantillas de figuras geométricas. En la revisión de la teoría de la Geometría Descriptiva se recoge la argumentación de Fernando Izquierdo1 , propuesta para desarrollar los aspectos que explican, sobre todo, los fundamentos de la Proyectiva. 56 páginas ISBN: 9789978325827 e-ISBN: 978997832579
Representación gráfica 2
Authors:   Universidad del Azuay, Larriva-Rivera Álvaro
Published: January 2023

A más de las nociones sobre los criterios de la Geometría y del Sistema Proyectivo, las aplicaciones que se resuelven en las etapas de preparación de los diseños se apoyan en una práctica constante por parte del alumno de pensar gráficamente, tras el proceso de revisar y precisar la información en secuencias de evaluación de los aspectos que definen el proyecto y que implican soluciones planteadas para comunicarlas en general a un usuario. El proceso requiere este trabajo mental previo, que tiende a constituirse en una fase de concepto, un modo de entender1 visualmente el espacio, para trasladarlo desde esas ideas iniciales y generales a los alcances de definir las especificaciones de la propuesta, mediante su descripción técnica. En este entrenamiento, el manejo del espacio representado se sigue dibujando en una estructura transparente, con líneas de trazado auxiliar que permiten disponer un proceso para evaluar la información, modificarla, reemplazarla, trasladarla, girarla, con miras a concluir el proyecto, al simular las condiciones de su construcción. 68 páginas ISBN: 978-9978-325-83-4 e-ISBN:978-9978-325-80-3
El IVA en el Ecuador: Un impuesto acumulativo
Authors:   Universidad del Azuay, Barrera-Crespo Boris
Published: January 2023

Además de lo dicho, se analizarán los incentivos que la legislación prevé para tipos específicos de contribuyentes –personas de la tercera edad y con discapacidad– y se estudiará la finalidad de incluir entre dichos beneficiarios a contribuyentes como los exportadores, compañías de aviación o empresas de turismo receptivo para las cuales el principio constitucional de igualdad material no es suficiente justificativo para una devolución de tributos. En este texto, asumimos la posición de que la normativa vigente debería concordar con el principio constitucional de justicia tributaria. Por tal motivo, el objetivo del estudio es sugerir argumentadamente recomendaciones para impulsar reformas legislativas al sistema tributario nacional. 114 páginas ISBN: 978-9978-325-90-2 e-ISBN:978-9978-325-91-9
Diseño de base de datos
Authors:   Universidad del Azuay, Merchán-Manzano Oswaldo
Published: January 2023

Este libro está dirigido a los estudiantes universitarios que cursan carreras relacionadas con las tecnologías de la información, los sistemas de información o con la informática. El libro está pensado como texto para un curso de un cuatrimestre sobre el diseño de bases de datos. El libro también se dirige a los profesionales como analistas de sistemas, programadores de aplicaciones y personas en general que están relacionadas con el uso de bases de datos o interesadas en aprender esta tecnología. 325 páginas ISBN: 978-9978-325-94-0 e-ISBN: 978-9978-325-59-9
Bofedales de Huaytire y anexos: diversidad, adaptación y perturbación
Authors:   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Franco León Pablo Juan , Franco Sulca Darwin ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Cáceres Musaja Cesar Nicolas ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Jove Chipana Cesar Augusto ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Ignacio Apaza Javier Máximo ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Navarro Guzmán Marco Alberto ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Oyague Passuni Eduardo Josué ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú
Published: January 2023

En la zona de la comunidad de Huaytire y anexos, de la provincia de Candarave, de la región Tacna, la actividad antrópica utiliza las aguas subterráneas a través de la explotación de pozos. Asimismo, las tendencias de los factores climatológicos como la escasa precipitación y la elevada evapotranspiración han determinado que grandes áreas del bofedal Huaytire se vean afectadas al reducirse las zonas de pastoreo de las comunidades campesinas. Al parecer, la sobreexplotación de acuíferos no ha tenido en cuenta los volúmenes de agua necesarios para asegurar el mantenimiento de estos ecosistemas. Debido a esto, los bofedales se han secado, ocasionando que entren en un proceso de desertificación; lo que a su vez provoca la reducción de los hatos de camélidos y, también, un cambio en la actividad productiva de los comuneros del lugar.
Impacto de la obesidad materna en la salud de la madre y su recién nacido
Authors:   Escuela Medicina Humana, Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Ticona Rendón Manuel Benedicto , Huanco-Apaza Danila Diana ,   Universidad Nacional Jorge Basadre Grohmann, Tacna, Perú, Ticona Huanco Diana Manuela ,   CIESMED Universidad Privada de Tacna, Tacna, Perú
Published: January 2023

Estudio de cohorte retrospectiva que evaluó el impacto de la obesidad y sobrepeso materno pregestacional en los resultados adversos maternos y perinatales durante los últimos 25 años. Se realizó en gestantes de embarazo único y sus recién nacidos cuyo parto fue atendido en el hospital Hipólito Unanue de Tacna durante los años 1995 a 2019. Se comparó grupos de sobrepeso y obesidad grados I, II y III, con las madres con normopeso. Para el análisis estadístico se utilizó riesgo relativo crudo y ajustado con intervalo de confianza al 95% y riesgo atribuible poblacional porcentual para aquellos riesgos significativos. Se encontró 34,4% de sobrepeso y 15,1% de obesidad, siendo 11,5% obesidad grado I, 2,8% grado II y 0,8% grado III, con tendencia ascendente durante los 25 años. Los resultados maternos adversos fueron: parto por cesárea, enfermedad hipertensiva del embarazo, diabetes mellitus, hemorragia del tercer trimestre, infección del tracto urinario, polihidramnios y oligoamnios. Los resultados perinatales adversos fueron: macrosomia fetal, grande para la edad gestacional y alteraciones hematológicas. Se concluye que en los últimos 25 años los resultados maternos y perinatales adversos atribuibles al sobrepeso y obesidad pregestacional han aumentado con la prevalencia creciente. Una proporción importante de estos resultados adversos podría evitarse con estrategias de prevención que reduzcan el peso materno antes del embarazo.