bluuebunny/crossref_metadata_2025 huggingface dataset:
Cultivating the Apprentice-Mentor Model for Minimally Invasive Gynaecology in the Era of Surgically Scarce Training: A Case Report of Laparoscopic Cornuostomy for Interstitial Ectopic Pregnancy by a Trainee
Authors: Listijono Dave R. , Rosen David M. B. , Choi Sarah , Bukhari Mujahid , Cario Gregory M. , Chou Danny
Published: March 2021

Over the last few years, there is an apparent growing concern amongst O&G trainees of the inadequacy in exposure to minimally invasive gynaecology surgical training, which has been inadvertently compounded by the more stringent working hour regulations and disproportionately increasing number of trainees relative to surgical volume. Therefore, it is vitally important for trainees to maximise opportunities in the operating theatre and develop autonomy in carrying out more complex surgical procedures. This case report outlines the step-by-step approach of laparoscopic excision of a cornual ectopic pregnancy performed by a trainee under the supervision of a surgical mentor. This manuscript highlights key characteristic traits of a trainee that serve to foster surgical trust and simple but effective steps to foster surgical preparedness.
The Potential to Replace Cement with Nano‐Calcium Carbonate and Natural Pozzolans in Cemented Mine Backfill
Authors: Hefni Mohammed , Ali Maaz A.
Published: March 2021

The effectiveness of mine backfilling depends on the properties of its constituents. The high cost of cement, which is commonly used as a binder in mine backfill, has led researchers to seek alternatives to partially replace it with other binders. This study investigated the potential to use nano‐calcium carbonate (NCC) and natural pozzolans (zeolite and pumice) along with Portland cement (PC) in mine backfill. Two types of experimental samples were prepared: (1) gold tailings and silica sand to investigate the effect of NCC and (2) nickel tailings to investigate the effect of natural pozzolans. The unconfined compressive strength (UCS) was measured for samples cured for up to 56 days. Moreover, selected samples were subject to mercury intrusion porosimetry to investigate microstructural properties. Results show that addition of NCC did not improve the UCS of backfill prepared with gold tailings and cured for 28 days, whereas a dosage of 1% NCC in backfill samples prepared with silica sand improved UCS by 20%, suggesting that the gold tailings negatively affected strength development. Natural pozzolans, in particular, 20% zeolite, had 24% higher UCS after 56 days of curing compared to samples prepared with PC and thus have the potential to partially replace cement in mine backfill.
Trainability of Health-Related and Motor Performance Fitness in Adults with Cystic Fibrosis within a 12-Month Partially Supervised Exercise Program
Authors: Welsner Matthias , Gruber Wolfgang , Mellies Uwe , Olivier Margarete , Sutharsan Sivagurunathan , Taube Christian , Dillenhoefer Stefanie , Koerner-Rettberg Cordula , Stehling Florian
Published: March 2021

Background. Regular physical activity plays an important role in the treatment of patients with cystic fibrosis (CF). This study is aimed at investigating the effects of a 12-month partially supervised exercise program on attributes of health-related and motor performance fitness, lung function (ppFEV1), BMI, and habitual physical activity (HPA, steps/day) in adults with CF. Methods. Attributes of health-related and motor performance fitness were examined at the beginning (T0), after 6 (T1), and 12 months (T2) on the basis of five test items: forward bend (FB), bent knee hip extension (HE), plank leg raise (PLR), standing long jump (SLJ), and standing on one leg (OLS). Additionally, we recorded HPA by accelerometry, peak exercise performance (

W

peak

) by an incremental cycle test, ppFEV1, and BMI. During the first six months, there was close supervision by an experienced sport therapist. Results. 26 CF patients (8 female, mean age

26.5
±
7.9

years; ppFEV1

53.7
±
21.0

) completed the exercise program. Significant improvements were recorded from T0 to T1 (FB:

p
≤
0.05

; PLR, OLS:

p
≤
0.01

) and from T0 to T2 (FB, PLR:

p
≤
0.01

and HE, OLS:

p
≤
0.05

).

W

peak

, ppFEV1, BMI, and HPA showed no significant improvement between the single test points and over the entire study period (all

p
>
0.05

). Conclusion. Our results show trainability of adults with CF in aspects of health-related and motor performance fitness during a partially supervised exercise program. Close supervision positively influences the results. Using a simple test setup seems to be a promising tool for evaluating the effects of exercise programs in CF and could serve as an additional outcome parameter in future clinical trials. Trial registration: ClinicalTrials.gov (retrospectively registered May 8, 2018).
Anti-TROVE2 Antibody Determined by Immune-Related Array May Serve as a Predictive Marker for Adalimumab Immunogenicity and Effectiveness in RA
Authors: Chen Po-Ku , Lan Joung-Liang , Chen Yi-Ming , Chen Hsin-Hua , Chang Shih-Hsin , Chung Chia-Min , Rutt Nurul H. , Tan Ti-Myen , Mamat Raja Nurashirin Raja , Anuar Nur Diana , Blackburn Jonathan M. , Chen Der-Yuan
Published: March 2021

Anti-drug antibody (ADAb) development is associated with secondary therapeutic failure in biologic-treated rheumatoid arthritis (RA) patients. With a treat-to-target goal, we aimed to identify biomarkers for predicting ADAb development and therapeutic response in adalimumab-treated patients. Three independent cohorts were enrolled. In Cohort-1, 24 plasma samples (6 ADAb-positive and 6 ADAb-negative patients at baseline and week 24 of adalimumab therapy, respectively) were assayed with immune-related microarray containing 1,636 correctly folded functional proteins. Next, we executed statistically powered autoantibody profiling analysis of 50 samples in Cohort-2 (24 ADAb-positive and 26 ADAb-negative patients). Subsequently, immunofluorescence assay was performed on 48 samples in Cohort-3 to correlate with ADAb titers and drug levels. The biomarkers were identified for predicting ADAb development and therapeutic response using the immune-related microarray and machine learning approach. ADAb-positive patients had lower drug levels at week 24 (

median
=
0.024
 
μ
g
/
ml

) compared with ADAb-negative patients (

median
=
6.38
 
μ
g
/
ml

,

p
<
0.001

). ROC analysis based on the ADAb status revealed the top 20 autoantibodies with

AUC
≥
0.7

in differentiating both groups in Cohort-1. Analysis of Cohort-2 dataset identified a panel of 8 biomarkers (TROVE2, SSB, NDE1, ZHX2, SH3GL1, CARD9, PTPN20, and KLHL12) with 80.6% specificity, 77.4% sensitivity, and 79.0% accuracy in discriminating poor from EULAR responders. Immunofluorescence assay validated that anti-TROVE2 antibody could highly predict ADAb development and poor EULAR response (AUC 0.79 and 0.89, respectively). Multivariate regression analysis proved anti-TROVE2 antibody to be an independent predictor for developing ADAb. Immune-related protein microarray and replication analysis identified anti-TROVE2 antibody as a useful biomarker for predicting ADAb development and therapeutic response in adalimumab-treated patients.
Application of SHEPWM in Helicopter Transient Electromagnetic Based on the Subsection Control Approach
Authors: Gao Lihui , Yu Shengbao , Jiang Chunxia , Chen Nan , Chen Renhui , Huang Yong
Published: March 2021

Guaranteeing the quality of the transmitting current under low switching frequency conditions is the crucial point in the helicopter transient electromagnetic (HTEM) system which affects the efficiency and exploration accuracy. HTEM requires high efficiency and low switching loss of the inverter power supply due to the facts that HTEM uses air-launched and air-received measurement methods, and the power storage capacity of the airborne transmitting system is limited. Paradoxically, low switching frequency directly affects the transmitting waveform quality and thereby affects the detection accuracy. In this study, we present a semiperiodic mirror symmetry selective harmonic elimination pulse width modulation (SHEPWM) based on the subsection control approach to balance transmitting current quality and switching loss. In the SHEPWM method, the semiperiodic mirror symmetry SHEPWM nonlinear equations are established by the time frequency domain information of the inverter output voltage and resolved by the artificial neural network (ANN) algorithm to attain switching time sequence of desired transmitting current. The simulation and experimental results verify the effectiveness of the SHEPWM subsection control strategy, which can reduce the switching loss while ensuring the current waveform quality and detection accuracy.
Dental Fluorosis according to Birth Cohort and Fluoride Markers in an Endemic Region of Colombia
Authors: Saldarriaga Alexandra , Restrepo Manuel , Rojas-Gualdrón Diego F. , Carvalho Thamyris de Souza , Buzalaf Marilia Afonso Rabelo , Santos-Pinto Lourdes , Jeremias Fabiano
Published: March 2021

Objectives. To analyze changes in the dental fluorosis (DF) incidence according to a birth cohort and explore current exposure to DF in a case series. Methods. Repeated cross-sectional study of two periods: 2015 and 2018. Two standardized examiners registered DF using the Thylstrup-Fejerskov index in permanent teeth of children aged 7–18 years. Period and birth cohort frequencies were estimated by a generalized linear model, binomial family, and logarithmic link function. Period estimates are presented as prevalence ratios (PR) and birth cohort estimates as cumulative incidence ratios (RR); 95% confidence intervals and

P

values are reported. In a subsample of 37 volunteers (12.29 ± 2.63 years), the fluoride (F) concentration in toenails was measured using the HMDS diffusion method and an ion-specific electrode. Other samples from the local environment such as food, soil, and coal were also collected. Results. In 274 children, we found that nonsignificant increases between periods (PR = 1.17; 95% CI: 0.89–1.55) were not explained by birth cohort effects. A total of 37.8% of the subsample had a toenail F concentration ≥2 μg F/g. The salty snacks and seasoning had the highest F concentrations among local environmental samples. Conclusion. In this population with a high DF frequency according to birth cohort and the evaluated period, the study of soil, coal, and food samples indicated a continued F exposure. F concentration found in the toenails shows a moderate F exposure; nearly a third of the children and adolescents exceeded the adopted threshold of 2 μg F/g. It is important to monitor and explore changes in exposure in highly affected population.
Coexpressed Genes That Promote the Infiltration of M2 Macrophages in Melanoma Can Evaluate the Prognosis and Immunotherapy Outcome
Authors: Yan Kexin , Wang Yutao , Lu Yuxiu , Yan Zhangyong
Published: March 2021

Purpose. To improve immunotherapy efficacy for melanoma, a coexpression network and key genes of M2 macrophages in melanoma were explored. A prognostic risk assessment model was established for M2-related coexpressed genes, and the role of M2 macrophages in the immune microenvironment of melanoma was elucidated. Method. We obtained mRNA data from melanoma and peritumor tissue samples from The Cancer Genome Atlas-skin cutaneous melanoma (TCGA-SKCM). Then, we used CIBERSORT to calculate the proportion of M2 macrophage cells. A coexpression module most related to M2 macrophages in TCGA-SKCM was determined by analyzing the weighted gene coexpression network, and a coexpression network was established. After survival analysis, factors with significant results were incorporated into a Cox regression analysis to establish a model. The model’s essential genes were analyzed using functional enrichment, GSEA, and subgroup and total carcinoma. Finally, external datasets GSE65904 and GSE78220 were used to verify the prognostic risk model. Results. The yellow-green module was the coexpression module most related to M2 macrophages in TCGA-SKCM; NOTCH3, DBN1, KDELC2, and STAB1 were identified as the essential genes that promoted the infiltration of M2 macrophages in melanoma. These genes are concentrated in antigen treatment and presentation, chemokine, cytokine, the T cell receptor pathway, and the IFN-γ pathway. These factors were analyzed for survival, and factors with significant results were included in a Cox regression analysis. According to the methods, a model related to M2-TAM coexpressed gene was established, and the formula was

risk
 
score
=

0.25

∗

NOTCH
3
+

0.008

∗

 
DBN
1
−

0.031

∗

KDELC
2
−

0.032

∗

STAB
1

. The new model was used to perform subgroup evaluation and external queue validation. The results showed good prognostic ability. Conclusion. We proposed a Cox proportional hazards regression model associated with coexpression genes of melanoma M2 macrophages that may provide a measurement method for generating prognosis scores in patients with melanoma. Four genes coexpressed with M2 macrophages were associated with high levels of infiltration of M2 macrophages. Our findings may provide significant candidate biomarkers for the treatment and monitoring of melanoma.
Efficacy and Mechanism of Ultrasound Combined with Slightly Acidic Electrolyzed Water for Inactivating Escherichia coli
Authors: Guo Liping , Zhang Xuecong , Xu Lin , Li Yan , Pang Bin , Sun Jingxin , Wang Baowei , Huang Ming , Xu Xinglian , Ho Harvey
Published: March 2021

In the present study, the synergetic effect and mechanism of ultrasound (US) and slightly acidic electrolyzed water (SAEW) on the inactivation of Escherichia coli (E. coli) were evaluated. The results showed that US combined with SAEW treatment showed higher sanitizing efficacy for reducing E. coli than US and SAEW alone treatment. US and US combined with SAEW treatments resulted in smaller particle size of E. coli compared to the control and SAEW treatment. In addition, US combined with SAEW treatment induced the highest potassium leakage. However, the highest protein leakage was recorded in US treatment. Moreover, scanning and transmission electron microscopy analysis revealed that the greatest damage of the appearance and ultrastructure of E. coli was achieved after US combined with SAEW treatment. The synergetic effect was also confirmed by CLSM analysis. Fluorescence spectroscopy suggested that treatments of US, SAEW, and US combined with SAEW changed protein conformation of E. coli. Overall, the present study demonstrated that the sterilization mechanism of US combined with SAEW treatment was decreasing the particle size and disrupting the permeability of cell membrane and the cytoplasmic ultrastructure as well as changing protein conformation of E. coli.
Assessment of Equipment Operation State with Improved Random Forest
Authors: Yang Na , Liu She , Liu Jie , Li Changjie
Published: March 2021

To accurately assess the state of a generator in wind turbines and find abnormalities in time, the method based on improved random forest (IRF) is proposed. The balancing strategy that is a combination of oversampling technique (SMOTE) and undersampling is applied for imbalanced data. Bootstrap is applied to resample original data sets of generator side from the supervisory control and data acquisition (SCADA) system, and decision trees are generated. After the decision trees with different classification capabilities are weighted, an IRF model is established. The accuracy and performance of the model are based on 10-fold cross-validation and confusion matrix. The 60 testing sets are assessed, and the accuracy is 95.67%. It is more than 1.67% higher than traditional classifiers. The probabilities of 60 data sets at each class are calculated, and the corresponding state class is determined. The results show that the proposed IRF has higher accuracy, and the state can be assessed effectively. The method has a good application prospect in the state assessment of wind power equipment.
Electroacupuncture Pretreatment Regulates Apoptosis of Myocardial Ischemia-Reperfusion Injury in Rats Through RhoA/p38MAPK Pathway Mediated by miR-133a-5p
Authors: Han Yongli , Chen Song , Wang Hua , Peng Xing-ming
Published: March 2021

The electroacupuncture (EA) pretreatment possesses a beneficial effect on myocardial ischemia/reperfusion (I/R) injury. However, the molecular mechanism of the EA effect is not fully understood. The study aimed to explore the protective effect of EA pretreatment on myocardial ischemia-reperfusion injury (MIRI) and apoptosis-related mechanisms in rats. Rats underwent in vivo myocardial ischemia-reperfusion, EA pretreatment, or intravenous injection of antagomirs. Cardiac function, infarct area, and myocardial cell apoptosis were measured. Meanwhile, the expressions of MKK3, MKK6, p38MAPK, Bax, Bcl-2, and Caspase-3 were also detected. We found that EA pretreatment significantly reduced infarct area and myocarpal cell apoptosis and enhanced cardiac function. EA pretreatment decreased the expression of Bax, Caspase-3, MKK3, MKK6, p38MAPK, Bax, and Caspase-3. In conclusion, The EA pretreatment down regulated the expression of MKK3, MKK6, and p38MAPK through the RhoA/p38MAPK pathway. EA pretreatment protect MIRI rats from apoptosis by down regulating the expression of MKK3, MKK6, and p38MAPK, thereby reducing the expression of Bax, Caspase-3 and up regulating the expression of Bcl-2, which mechanism is closely related to the RhoA/p38MAPK pathway mediated by miR-133a-5p.
The Genetic and Epigenetic Mechanisms Involved in Irreversible Pulp Neural Inflammation
Authors: Xi Xiaoxi , Ma Yihong , Xu Yuzhen , Ogbuehi Anthony Chukwunonso , Liu Xiangqiong , Deng Yupei , Xi Junming , Pan Haitong , Lin Qian , Li Bo , Ning Wanchen , Jiang Xiao , Li Hanluo , Li Simin , Hu Xianda
Published: March 2021

Aim. To identify the critical genetic and epigenetic biomarkers by constructing the long noncoding RNA- (lncRNA-) related competing endogenous RNA (ceRNA) network involved in irreversible pulp neural inflammation (pulpitis). Materials and Methods. The public datasets regarding irreversible pulpitis were downloaded from the gene expression omnibus (GEO) database. The differential expression analysis was performed to identify the differentially expressed genes (DEGs) and DElncRNAs. Functional enrichment analysis was performed to explore the biological processes and signaling pathways enriched by DEGs. By performing a weighted gene coexpression network analysis (WGCNA), the significant gene modules in each dataset were identified. Most importantly, DElncRNA-DEmRNA regulatory network and DElncRNA-associated ceRNA network were constructed. A transcription factor- (TF-) DEmRNA network was built to identify the critical TFs involved in pulpitis. Result. Two datasets (GSE92681 and GSE77459) were selected for analysis. DEGs involved in pulpitis were significantly enriched in seven signaling pathways (i.e., NOD-like receptor (NLR), Toll-like receptor (TLR), NF-kappa B, tumor necrosis factor (TNF), cell adhesion molecules (CAMs), chemokine, and cytokine-cytokine receptor interaction pathways). The ceRNA regulatory relationships were established consisting of three genes (i.e., LCP1, EZH2, and NR4A1), five miRNAs (i.e., miR-340-5p, miR-4731-5p, miR-27a-3p, miR-34a-5p, and miR-766-5p), and three lncRNAs (i.e., XIST, MIR155HG, and LINC00630). Six transcription factors (i.e., GATA2, ETS1, FOXP3, STAT1, FOS, and JUN) were identified to play pivotal roles in pulpitis. Conclusion. This paper demonstrates the genetic and epigenetic mechanisms of irreversible pulpitis by revealing the ceRNA network. The biomarkers identified could provide research direction for the application of genetically modified stem cells in endodontic regeneration.
Creep Properties and Constitutive Model of Salt Rock
Authors: Zhang Qiang , Song Zhanping , Wang Junbao , Zhang Yuwei , Wang Tong
Published: March 2021

Due to the advantages of low porosity, low permeability, high ductility, and excellent capacities for creep and damage self‐healing, salt rock is internationally considered as the ideal medium for underground storage of energy and disposal of radioactive waste. As one of the most important mechanical properties of salt rock, creep properties are closely related to the long‐term operation stability and safety of salt rock underground storage cavern. A comprehensive review on the creep properties and constitutive model of salt rock is put forward in this paper. The opinions and suggestions on the research priority and direction of salt rock′s mechanical properties in the future are put forward: (1) permeability variation of salt rock under the coupling effect of temperature and stress; (2) damage mechanism and evolution process under the effect of creep‐fatigue interaction and low frequency cyclic loading; (3) microdeformation mechanisms of salt rock and the relationship between microstructure variations and macrocreep behavior during creep process; (4) the establishment of the creep damage constitutive model with simple form, less parameters, easy application, and considering the damage self‐healing ability of salt rock simultaneously.
El Puntapié Inesperado Preguntas sobre el futuro de las Escuelas de Negocios en Chile
Authors: Subiabre Juan Pablo
Published: March 2021

En el presente artículo planteo algunas inquietudes sobre el futuro de las escuelas de negocios en Chile. Estas interrogantes nacen a raíz de la actual crisis sanitaria y la transformación que ésta ha desencadenado en las relaciones laborales y en el mundo organizacional. Para ello, comenzaré explicando los efectos que el impasse relevancia-rigor ha tenido en el modelo de desarrollo adoptado por las escuelas de negocios en las últimas décadas. A continuación, planteo que, si bien la adopción de este modelo reportó enormes beneficios en el pasado, hoy en día resulta un impedimento para adaptarse de forma ágil a un entorno impredecible. Finalmente, sugiero que la pandemia debiera catalizar una serie de cambios en la forma en que las escuelas de negocios entienden su relación con lo humano.
El año que vivimos en peligro: Un antes y después para la Educación en Negocios
Authors: Mandiola-Cotroneo Marcela
Published: March 2021

El año 2020 ha venido a establecer un quiebre de proporciones a la cotidianeidad de la vida. Nuestro modo de habitar, de producir, de relacionarnos, se ha visto interrumpido, más bien detenido, y con ello nos hemos enfrentado a la abrupta y obligatoria oportunidad de observarnos y reflexionar. Lo que vivimos hoy no solo se trata de una emergencia sanitaria o un problema de salud pública. En un mundo globalizado que se ha articulado a través de relaciones de mercado dinámicas y competitivas, la detención y el confinamiento han causado estragos. Lo que emerge como más grave aún, es la falta de alternativas para organizar los modos de sostener la materialidad de la vida a consecuencia directa de una concepción económica monocorde y hegemónica que se quedó sin ‘propuesta de valor’ ante una ‘externalidad’ que nunca modeló. Vis a vis, las estrategias de gestión surgidas al alero de dicha visión económica, y que han sido amplia y hegemónicamente difundidas a través de la educación en negocios tradicional, alcanzan también su límite. Basta una mirada superficial a los contenidos y metodologías de los programas académicos asociados a la disciplina de la administración para darnos cuenta que seguimos educando para una mundo que ya no existe. Urge, apremia, más que nunca, revisar, revisitar y desafiar lo que hemos entendido hasta ahora como educación en negocios.
Patient-Derived Organoids for Precision Cancer Immunotherapy
Authors: Grönholm Mikaela , Feodoroff Michaela , Antignani Gabriella , Martins Beatriz , Hamdan Firas , Cerullo Vincenzo
Published: March 2021

Cancer immunotherapy has revolutionized the way tumors are treated. Nevertheless, efficient and robust testing platforms are still missing, including clinically relevant human ex vivo tumor assays that allow pretreatment testing of cancer therapies and selection of the most efficient and safe therapy for a specific patient. In the case of immunotherapy, this testing platform would require not only cancer cells, but also the tumor microenvironment, including immune cells. Here, we discuss the applications of patient-derived tumor organoid cultures and the possibilities in using complex immune–organoid cultures to provide preclinical testing platforms for precision cancer immunotherapy.
Catch-up HPV Vaccination and Subsequent Uptake of Papanicolaou Testing in A State-mandated Health System
Authors: Chodick Gabriel , Leader Amy E. , Larson Sharon
Published: March 2021

The objective of this study was to evaluate the association between human papillomavirus (HPV) vaccination and uptake of initial Papanicolaou (Pap) testing in Israel among women not previously vaccinated through the national immunization program. In this retrospective cohort we used health provider records of vaccinations and cancer screening attendance among female members of a state-mandated health provider in Israel (Maccabi Healthcare Services, MHS). All eligible female members (N = 20,904) immunized with at least one dose of HPV vaccine from the date of its introduction in Israel (June 2007) until December 31, 2018 were individually matched with nonvaccinated MHS members on one to one ratio by year of birth, residential area socioeconomic level, and district of residence. Data on the uptake of Pap smears until December 2018 were extracted from MHS central datasets, and the number of Pap smears for each woman during the study period was counted. During the observed follow-up period (mean, 6.6 years; interquartile range, 3.9–8.7 year), the cumulative uptake rate of Pap testing in vaccinated women (26.8%) was significantly (P < 0.001) greater than among unvaccinated (22.4%) women. In a multivariable model, HPV vaccination was associated with an HR of 1.34 [95% confidence interval (CI), 1.29–1.41] to perform Pap testing. Our findings suggest that uptake of catch-up HPV vaccine was positively correlated to increased uptake of Pap testing.

Prevention Relevance:

We found that catch-up HPV vaccination was associated with increased attention to long-term cervical screening attendance. Whereas, those who are not vaccinated and unprotected from HPV, are more likely to abstain from secondary prevention screening tests too and further increase their cervical cancer risk.
A adaptação da narrativa-game de Halliday’s Easter Egg Hunt para o filme Ready Player One
Authors: Araujo Fernanda Martins Ferreira de , Marins Líliam Cristina
Published: March 2021

O videogame fictício Halliday’s Easter Egg Hunt, presente no romance Ready Player One (Cline, 2011), é uma ode ao universo geek da década de 1980, uma vez que apresenta, no formato de Easter Eggs, elementos culturais (principalmente filmes e jogos) da década mencionada. No ano de 2018, o estúdio Warner Brothers lançou a adaptação cinematográfica desse romance, questionando a afirmação de Cline sobre a inadaptabilidade de sua obra. O presente trabalho propõe uma análise das soluções encontradas pelos adaptadores, considerados como co-criadores nesta abordagem (Hutcheon, 2013), ao adaptar a narrativa-game (Aarseth, 1997; 2005) apresentada no livro para a estética cinematográfica. A análise da adaptação demonstrou que tanto a estética cinematográfica (Edgar-Hunt, Marland e Rawle, 2010; Bordwell e Thompson, 2013) quanto os princípios estruturais de um game nortearam a transformação do meio impresso para o cinematográfico.
A Blancanieves Andaluza de Pablo Berger: Tradução e Intermidialidade
Authors: Cunha Roseli Barros
Published: March 2021

Em 2012, Schneewittchen – ou Branca de Neve, como a conhecemos em português –, dos irmãos Jacob e Wilhelm Grimm (1812), ganha mais uma releitura. O filme Blancanieves, do diretor Pablo Berger, é inspirado no conto (mais especificamente, Märchen) recolhido da tradição oral pelos filólogos alemães. A proposta deste artigo é, partir de duas traduções para o português do Brasil, a saber, a de Tatiana Belinky (2013) e a de Christine Röhrig (2014), examinar as relações intermidiáticas entre as obras literária e cinematográfica à luz dos estudos de Irina Rajewsky (2012) e Claus Clüver (2011), principalmente, no que se refere à caracterização da personagem principal, Branca de Neve, de seus pais, do lugar e da época onde ocorre a ação tanto do conto quanto do filme. Na produção de Berger, personagens, espaço e tempo contidos na obra dos Grimm são evidentemente ressignificados a partir de elementos do flamenco e das touradas, associados à cultura tradicional cigana presente, por sua vez, na tradição popular do sul da Espanha. A presença desses elementos faz com que a obra dialogue com outras produções bastante conhecidas sobre tais temáticas e os estereótipos que se perpetuam em relação a elas tanto na Espanha quanto fora dela ao longo de séculos. Analiso como ocorre o processo de ressignificação e de que modo ela discute ou não conceitos e preconceitos sobre elementos populares e tradicionais muito associados ao que se costuma entender por ‘cultura espanhola’, principalmente a partir do apoio teórico de Rafael Jover (2007), Francisco Aix Gracia (2002) e Gerhard Steingresse (2002).
Tradução coletiva e criativa do Entremés de la Ropavejera, de Quevedo y Villegas
Authors: Cesco Andréa , Távora Beatrice
Published: March 2021

A tradução coletiva é apontada por Haroldo de Campos (2010) como um dos caminhos possíveis para textos possuidores de alta complexidade e que, em princípio, seriam intraduzíveis. O trabalho de cooperação, através de uma equipe orientada para um alvo comum seria, segundo o autor, uma possibilidade de abordagem que poderia fomentar traduções criativas, voltadas para a manutenção do signo estético em detrimento de uma fidelidade ao significado textual. A partir destes postulados, este artigo se propõe a socializar a experiência de tradução coletiva do Entremés de la Ropavejera (1670), de Francisco de Quevedo y Villegas (1580-1645), realizada pelo Núcleo Quevedo de Estudos Literários e Traduções do Século de Ouro, da UFSC, enfatizando reflexões e escolhas envolvidas nesse processo. A história do entremez gira em torno da personagem ropavejera (remendeira), que atende na sua loja os clientes que chegam em busca de pomadas, postiços e ‘peças de reposição’ para remendar ou reparar em seus corpos o dano causado pela idade. As discussões acerca do processo tradutório do texto permitiram a elaboração de uma metodologia de trabalho que envolveu a utilização de vários recursos, como o acesso a dicionários especializados e de época, a consulta à crítica literária e à pesquisa histórica para a aproximação ao contexto de produção, que aqui são apresentados e discutidos. Pretende-se, desta forma, contribuir com a divulgação dos estudos sobre o Século de Ouro no cenário nacional.
Os desafios de traduzir o humor político para o português: escolhas tradutórias para Tutta Casa, Letto e Chiesa, de Franca Rame e Dario Fo
Authors: Mello Amanda Bruno de
Published: March 2021

A peça Tutta Casa, Letto e Chiesa (1977) de Franca Rame e Dario Fo, é uma peça composta por seis monólogos para uma atriz, escrita em um período de grande polarização política na Itália. Seu fio condutor é a condição da mulher, assim como a luta por maior igualdade. Os monólogos possuem um tom cômico, elementos épicos e relação com o contexto político italiano da época. Traduzi-los para o português foi desafiador por vários motivos, muitos dos quais se relacionam ao dilema de conciliar elementos antagônicos: o espectador deve ter certa familiaridade com os temas tratados para que o riso possa acontecer, como teoriza Bergson (2020); além da importância de manter, na tradução, as referências ao contexto político em que o espetáculo foi escrito. Este trabalho analisa três situações em que esse dilema se manifestou, apresenta as escolhas tradutórias tomadas e suas justificativas.
Sobre a tradução em prosa comentada de trechos da obra Midsummer Night And Other Tales In Verse, de John Masefield
Authors: Dias Natalia Ferrigolli , Rimoli Pisetta Lenita Maria
Published: March 2021

Esta pesquisa almejou cooperar com a temática dos estudos arturianos, apresentando a tradução em prosa de excertos da obra Midsummer Night and Other Tales in Verse (1928), do poeta John Masefield (1878-1967), ainda pouco conhecido no Brasil. Segundo nossas pesquisas, esta é a primeira tradução para o português brasileiro dessa obra, da qual foram selecionados episódios-chave, apresentados de acordo com sua ordem de aparição no livro. Foram escolhidos dois do total de vinte e dois episódios, incluindo aquele que dá o nome à obra. Optou-se por realizar a tradução em prosa por se tratar de uma pesquisa inicial e para que o texto ficasse mais acessível aos leitores da atualidade.
Confucius Confronting Contingency in the Lunyu and the Gongyang Zhuan
Authors: Gentz Joachim
Published: March 2021

The article argues in the first part that the Lunyu
is the only early text in which Confucius is not depicted as the ultimate sage authority who knows an answer to all questions. Instead the Confucius of the Lunyu leaves questions open and points out limits of possible knowledge. The second part of the article shows that in the exegesis of the Gongyang Zhuan
we find exactly the same attitudes of Confucius. The article argues in the third part that the specific character of the Lunyu construction of Confucius lies in its ascribing to him professional attitudes found in the realm of historiography and ritual expertise.
Cosmology, Society, and Humanity: Tian in the Guodian Texts (Part II)
Authors: Chan Shirley
Published: March 2021

In this sequel of my previous publication, I will continue my discussion of the word tian
as it appears in the Guodian texts. I shall argue that, from natural order arises xing
, human’s distinctive potentiality, which is endowed by heaven to follow and be guided by the heavenly principle. I thereafter will elaborate the sages’ role as cultural creators. The distinct roles of heaven and humanity are further deepened when tian and ming
are perceived as the determinants of an individual’s success or failure. I will go on to show how the word tian can be understood as the source or underlying pattern that brings about coincidental or synchronous events and experiences.
Zhu Xi’s Spirituality: A New Interpretation of the Great Learning
Authors: Arghirescu Diana
Published: March 2021

This essay analyzes the spiritual dimension of Zhu Xi’s thought as reflected in his commentary on the four inner stages of the Great Learning (the Daxue
). I begin with a presentation of the notions “spirituality,” “religion,” and “practice,” and of the interpretative methods used. I then examine the signification of Zhu Xi’s Neo-Confucian numinous root as embodied in the luminous moral potentiality, investigate from this perspective each one of the four inner stages of the Great Learning, and point out the main attribute of the spiritual. I conclude with a portrait of the person for whom this method of practice was intended.
Analogical Propositions in Moist Texts
Authors: Yuan Jinmei
Published: March 2021

This article is an effort to improve understanding between Moist and Aristotelian logics on analogy. I argue that Chinese logic can neither fit in Aristotelian deductive framework, nor completely fit in Aristotelian inductive framework. One of the major reasoning skills that ancient Chinese logicians applied is analogical reasoning. Having examined thirteen Moist analogical propositions in a Moist text, the Da Qu from the perspective of finding rationales (li ) among things, I conclude that if the rationales can be found in a changing world, then Chinese logicians seek for the “beauty of creative thinking” in the process of argumentation.
Mapping Kant’s Architectonic onto the Yijing via the Geometry of Logic
Authors: Palmquist Stephen R.
Published: March 2021

Both Kant’s architectonic and the Yijing can be structured as four perspectival levels: 0 + 4 + 12 + (4 ¥ 12) = 64. The first, unknowable level is unrepresentable. The geometry of logic provides well-structured maps for levels two to four. Level two consists of four basic gua (2, 64, 63, 1), corresponding to Kant’s category-headings (quantity, quality, relation, modality). Level three’s twelve gua, derived logically from the initial four, correspond to Kant’s twelve categories. Level four correlates the remaining 48 gua (in twelve sets of four) to Kant’s theory of the four university faculties (philosophy, theology, law, medicine), and to four categorially organized (twelvefold) domains comprising his philosophical system.
Lao-Zhuang and Heidegger on Nature and Technology
Authors: Parkes Graham
Published: March 2021

Many of our current environmental problems stem from damage to the natural world through excessive use of modern technologies. Since these problems are now global in scope, it is helpful to take a comparative philosophical approach—in this case by way of Laozi, Zhuangzi, and Martin Heidegger. Heidegger’s thoughts on these topics are quite consonant with classical Daoist thinking, in part because he was influenced by it. Although Zhuangzi and Heidegger warn against the ways technology can impair rather than promote human flourishing, they are not simply anti-technological in their thinking. Both rather recommend a critical stance that would allow us to shift to a more reflective employment of less disruptive technologies.
“Waiting for Godot”? Contemporaneity, Feminism, and Creativity
Authors: Gu Linyu
Published: March 2021

This article speaks to contemporary women and men, who both suffer from gender issues such as disconnection, separation, oppression … and who forever wait for a so-called “tomorrow.” Through comparing process thought and Chinese philosophy, my study analyzes how process feminism synthesizes our demands for interconnection and how it alerts our narrow desires in seeking “a way out.” I further challenge a fundamental weakness in this genre of Whitehead’s organic multiplicity by contributing “creative harmony” of yin
and yang
in the Yijing
cosmology. This contribution offers process feminism a humanistic “creative creativity,” which avoids the oversight in Whiteheadian philosophy of organism and therefore prospects that the mutual connectivity in Chinese cosmology is “a way through” the actual practicability of both men and women, who share a common goal.
Passionate Epistemology: Kierkegaard on Skepticism, Approximate Knowledge, and Higher Existential Truth
Authors: Carson Nathan P.
Published: March 2021

In this article, I probe the extent of Kierkegaard’s skepticism and irrationalism by examining the nature and limits of his “objective” and “approximate” knowledge. I argue that, for Kierkegaard, certain objective knowledge of contingent being is impossible and “approximate” knowledge of the same is funded by the volitional passion of belief. But, while Kierkegaard endorses severe epistemic restrictions, he rejects wholesale skepticism, allowing for genuine “approximate” knowledge of mind-independent reality. However, I further argue that we cannot ignore his criticisms of such knowledge because of its intrinsic dangers, and because epistemic limitations are crucial in developing religious selfhood before God.
Sublating Reverence to Parents: A Kierkegaardian Interpretation of the Sage-King Shun’s Piety
Authors: Pfister Lauren F.
Published: March 2021

In the Mengzi there is a hypothetical situation relating how the ancient sage-king Shun would respond if his father had committed murder. This has recently become a source of debate among Chinese philosophers. Here we will apply arguments made by Johannes de silentio (Kierkegaard’s pseudonym) about the “teleological suspension of the ethical” related to the action of the biblical Abraham, and link them up to alternative interpretations of the actions of Shun. This challenges the current and traditional interpretations of his actions, suggesting how this new approach can overcome ethical quandaries related to the Mengzian account of Shun’s behavior.
Kierkegaard and the Faith of Chinese Christians in Business
Authors: Mccann Dennis P.
Published: March 2021

Chinese philosophers today are challenged to make sense of faith in God, and particularly Christian faith as expressed by Chinese Christians, as an existential affirmation centering their personal and social lives. I offer here a philosophical approach to Christian faith, based upon interpretations of Søren Kierkegaard’s work, Sickness unto Death. Kierkegaard’s phenomenology of Christian conversion helps us understand and evaluate the recently obtained testimonies of 37 Hong Kong Chinese Christian business executives. Our study reveals not only what Christian faith means to our informants, but also how Kierkegaard’s interpretations are helpful in attempting a philosophical analysis of their testimonies.
Historical Identity in the Shangshu
Authors: Yi Ning , Wang Xianhua
Published: March 2021

The Zhoushu
section of the Shangshu
, reflecting on the dynastic changes from Xia to Shang and from Shang to Zhou, understands “heavenly mandate” as the common element that brings about all changes within a historical continuum. For Zhoushu, it is “heavenly mandate” that makes historical continuity possible. Furthermore, “heavenly mandate” is understood to manifest itself with the hopes of the common people and to be realized by the freewill of the king. Thus historical changes can be accommodated. The Chinese idea of historical identity continued to be enriched after the Chun Qiu Period. But in terms of its characteristic understandings of history, it remained much the same as in the Zhoushu: Interpreting history with a common element recognized therein, with the stress always on continuity though historical changes are accommodated from a humanist perspective.
Recognition and Resentment in the Confucian Analects
Authors: Nelson Eric S.
Published: March 2021

Early Confucian “moral psychology” developed in the context of undoing reactive emotions in order to promote relationships of reciprocal recognition. Early Confucian texts diagnose the pervasiveness of reactive emotions under specific social conditions and respond with the ethical-psychological mandate to counter them in self-cultivation. Undoing negative affects is a basic element of becoming ethically noble, while the ignoble person is fixated on limited self-interested concerns and feelings of being unrecognized. Western ethical theory typically accepts equality and symmetry as conditions of disentangling resentment; yet this task requires the asymmetrical recognition of others. Confucian ethics integrates a nuanced and realistic moral psychology with the normatively oriented project of self-cultivation necessary for dismantling complex negative emotions in promoting a condition of humane benevolence that is oriented toward others and achieved through self-cultivation.
The Frankfurt School and Chinese Marxist Philosophical Reflections Since the 1980s
Authors: Kang Liu
Published: March 2021

Since 1980s, the Frankfurt School’s critique of Culture Industry has provided powerful ammunitions for Chinese intellectuals to reject rising consumer popular culture. In recent years, Chinese academics began to study the Frankfurt School’s critique of capitalist modernity from more theoretical perspectives, attempting to set Chinese problems of modernity and its legitimacy against the Frankfurt School’s theorization. However, Chinese intellectuals’ diverse responses to the Frankfurt School have largely remained at the level of academic inquiries rather than seriously engaging in practically seeking alternatives. This study will consider issues of critique of and alternatives to capitalist modernity that modern Marxists or post-Marxists, be they Frankfurt School philosophers, the Chinese Marxists or the latter-day Chinese “new left,” all wish to seek out.
On Interphilosophical Sino-Western Dialogue in the Contemporary World
Authors: Gálik Marián
Published: March 2021

This article tries to put forward the problems of theory of Comparative Philosophy into the broad framework of Sino-Western dialogue in our global age. It begins with the critical evaluation of New Confucianism as the best scholarly elaborated Chinese philosophy in modern times, which on the basis of integrative studies within the broad dialogue may be able to help to create the polymorphous philosophy(ies) congenial for the contemporary world. Sharing harmony but not uniformity on the background of different vistas such dialogue may contribute to this aim extremely important for the mankind. The article ends with remarks concerning the problems making such theory of Comparative Philosophy plausible.
The Goose Lake Monastery Debate (1175)
Authors: Ching Julia
Published: March 2021

The Goose Lake Monastery Debate was an important event in the history of Chinese thought, chiefly because it marked the differences between two of the greatest representatives of the movement of thought known in the West as Neo-Confucianism. In this article, it is my aim to offer a historical reconstruction of the events that took place, to give an exegetical analysis of the problems discussed, and to conclude with an interpretation that places these problems in a wider perspective. I hope to show how this event which occurred in China 800 years ago was not a hair-splitting affair with little consequence for men today, but that it concerned a problem that is both universal and contemporary: the conflict between learning and wisdom.
The Significance of Xiong Shili’s Interpretation of Dignāga’s Ālambana-Parīkṣā (Investigation of the Object)
Authors: Makeham John
Published: March 2021

This essay is an exercise in intellectual archaeology in which I seek to show that already in Xiong Shili’s first account of Yogācāra, Weishixue Gailun (A General Account of Yogācāra Learning) (1923), we are able to find the first indications of a critical attitude to Yogācāra that would grow in intensity over the following two decades. These critiques served the rhetorical purpose of bolstering the authority of Xuanzang (seventh century). Before long, however, Xiong even rejected that authority.
A Political Constitution for the Pluralist World Society?
Authors: Habermas Jürgen
Published: March 2021

The chances of the project of a “cosmopolitan order” being successful are not worse now than they were in 1945 or in 1989–1990.This does not mean that the chances are good, but we should not lose sight of the scale of things. The Kantian project first became part of the political agenda with the League of Nations, in other words after more than 200 years; and the idea of a cosmopolitan order first received a lasting embodiment with the foundation of the United Nations (UN). This process points toward a continuation of the Kantian project. We can still take our cue from Kant’s idea of a cosmopolitan condition if we simply construe it in sufficiently abstract terms. I wish to show first of all why I consider the Kantian alternative between a world of republic and a league of nations to be incomplete (section I) and will then go on to outline how we can reconceptualize the Kantian project under contemporary conditions (section II).And I shall close by addressing an actual challenge to which that project might well offer the most promising response (section III).

Due to the author was not reachable, this journal has composed the Abstract with Editor-in-Chief’s instruction.
Mengzi and the Archimedean Point for Moral Life
Authors: Jiang Xinyan
Published: March 2021

“The Archimedean point for moral life” discussed in this article refers to the starting point of one’s moral reasoning and what ultimately makes moral life possible. The article intends to show that Mengzi’s doctrine of the Four Beginnings may throw some light on our search for such an Archimedean point. More specifically, it argues for the following: (1) Mengzi’s doctrine of the Four Beginnings actually takes moral sentiments as the Archimedean point for moral life; (2) Mengzi’s view of the starting point of moral reasoning and the ultimate ground for moral life not only can be empirically supported to a great extent, but also logically plausible.