bluuebunny/crossref_metadata_2025 huggingface dataset:
Mycotic aneurysm
Authors: Neth Bryan J , Cohen Cohen Salomon , Trejo-Lopez Jorge , Brinjikji Waleed , Braksick Sherri Ann , Fugate Jennifer E , Rabinstein Alejandro A , Wijdicks Eelco F M
Published: May 2022

Angioinvasive fungal infections of the cerebral vasculature often lead to significant morbidity and mortality. High clinical suspicion and early antifungal therapy could improve outcomes. We describe the fatal case of a patient with a rapidly enlarging cavernous carotid aneurysm due to angioinvasive fungus. This case highlights the challenges in diagnosis and management of this condition.
Conformation traits of Holstein cows and their association with a Canadian economic selection index
Authors: Alcantara Lucas M. , Baes Christine F. , de Oliveira Junior Gerson A. , Schenkel Flavio S.
Published: May 2022

Pro$ is a Canadian economic selection index aimed to maximize profit by increasing production yields, while maintaining conformation and functional traits. Currently, there is an interest in understanding the individual contributions of conformation traits recorded in Canada to the overall economic value of a cow and whether they are equally important. We used multiple polynomial regression and principal component analysis to assess the association of 26 conformation traits with Pro$ using relative breeding values (RBVs) from 9351 proven bulls. The best reduced regression model explained 72.5% of the variance in Pro$, with heel depth and body depth having the highest and lowest effect on Pro$ values, respectively. Four traits classified as intermediate optimum traits, e.g., teat length, showed significant linear association with Pro$ instead of quadratic, whereas bone quality was not significantly associated with the index. Principal component analysis indicated that highly profitable bulls share similar RBV, with a subclustering of bulls of daughters with better mammary system versus better dairy strength and feet and legs. These results provide understanding of the individual contributions of conformation traits to Pro$ and give information to guide the Canadian dairy industry on how to best consider these traits in recording and genetic evaluation programs.
Gaze as an Indicator of Input Recognition Errors
Authors: Peacock Candace E. , Lafreniere Ben , Zhang Ting , Santosa Stephanie , Benko Hrvoje , Jonker Tanya R.
Published: May 2022

Input recognition errors are common in gesture- and touch-based recognition systems, and negatively affect user experience and performance. When errors occur, systems are unaware of them, but the user's gaze following an error may provide valuable cues for error detection. A study was conducted using a manual serial selection task to investigate whether gaze could be used to discriminate user-initiated selections from injected false positive selection errors. Logistic regression models of gaze dynamics could successfully identify injected selection errors as early as 50 milliseconds following a selection, with performance peaking at 550 milliseconds. A two-phase gaze pattern was observed in which users exhibited high gaze motion immediately following errors, and then decreased gaze motion as the error was noticed. Together, these results provide the first demonstration that gaze dynamics can be used to detect input recognition errors, and open new possibilities for systems that can assist with error recovery.
Gaze-Hand Alignment
Authors: Lystbæk Mathias N. , Rosenberg Peter , Pfeuffer Ken , Grønbæk Jens Emil , Gellersen Hans
Published: May 2022

Gaze and freehand gestures suit Augmented Reality as users can interact with objects at a distance without need for a separate input device. We propose Gaze-Hand Alignment as a novel multimodal selection principle, defined by concurrent use of both gaze and hand for pointing and alignment of their input on an object as selection trigger. Gaze naturally precedes manual action and is leveraged for pre-selection, and manual crossing of a pre-selected target completes the selection. We demonstrate the principle in two novel techniques, Gaze&Finger for input by direct alignment of hand and finger raised into the line of sight, and Gaze&Hand for input by indirect alignment of a cursor with relative hand movement. In a menu selection experiment, we evaluate the techniques in comparison with Gaze&Pinch and a hands-only baseline. The study showed the gaze-assisted techniques to outperform hands-only input, and gives insight into trade-offs in combining gaze with direct or indirect, and spatial or semantic freehand gestures.
Feasibility of Longitudinal Eye-Gaze Tracking in the Workplace
Authors: Hutt Stephen , Stewart Angela E.B. , Gregg Julie , Mattingly Stephen , D'Mello Sidney K.
Published: May 2022

Eye movements provide a window into cognitive processes, but much of the research harnessing this data has been confined to the laboratory. We address whether eye gaze can be passively, reliably, and privately recorded in real-world environments across extended timeframes using commercial-off-the-shelf (COTS) sensors. We recorded eye gaze data from a COTS tracker embedded in participants (N=20) work environments at pseudorandom intervals across a two-week period. We found that valid samples were recorded approximately 30% of the time despite calibrating the eye tracker only once and without placing any other restrictions on participants. The number of valid samples decreased over days with the degree of decrease dependent on contextual variables (i.e., frequency of video conferencing) and individual difference attributes (e.g., sleep quality and multitasking ability). Participants reported that sensors did not change or impact their work. Our findings suggest the potential for the collection of eye-gaze in authentic environments.
Human Movement Datasets: An Interdisciplinary Scoping Review
Authors: Olugbade Temitayo , Bieńkiewicz Marta , Barbareschi Giulia , D’amato Vincenzo , Oneto Luca , Camurri Antonio , Holloway Catherine , Björkman Mårten , Keller Peter , Clayton Martin , Williams Amanda C De C , Gold Nicolas , Becchio Cristina , Bardy Benoît , Bianchi-Berthouze Nadia
Published: May 2022

Movement dataset reviews exist but are limited in coverage, both in terms of size and research discipline. While topic-specific reviews clearly have their merit, it is critical to have a comprehensive overview based on a systematic survey across disciplines. This enables higher visibility of datasets available to the research communities and can foster interdisciplinary collaborations. We present a catalogue of 704 open datasets described by 10 variables that can be valuable to researchers searching for secondary data: name and reference, creation purpose, data type, annotations, source, population groups, ordinal size of people captured simultaneously, URL, motion capture sensor, and funders. The catalogue is available in the supplementary materials. We provide an analysis of the datasets and further review them under the themes of human diversity, ecological validity, and data recorded. The resulting 12-dimension framework can guide researchers in planning the creation of open movement datasets. This work has been the interdisciplinary effort of researchers across affective computing, clinical psychology, disability innovation, ethnomusicology, human-computer interaction, machine learning, music cognition, music computing, and movement neuroscience.
Piezo1 regulates shear-dependent nitric oxide production in human erythrocytes
Authors: Kuck Lennart , Peart Jason N. , Simmonds Michael J.
Published: May 2022

The mechanosensitive ion channel Piezo1 is expressed in enucleated red blood cells and provides a mechanisms of shear-induced red cell nitric oxide production via nitric oxide synthase phosphorylation. Thiol oxidation of red cells decreases Piezo1-dependent calcium movement and thus impairs nitric oxide generation in response to mechanical force. The emerging descriptions of exclusively posttranslational signaling networks in circulating red cells as acute regulators of cell function support that these cells play an important role in cardiovascular physiology that extends beyond passive oxygen transport.
Essential Norms of Stević–Sharma Operators from General Banach Spaces into Zygmund‐Type Spaces
Authors: Bakhit M. A.
Published: May 2022

A Stević–Sharma operator denoted by is a generalization product of multiplication, differentiation, and composition operators. Using several restrictive terms, we characterize an approximation of the essential norm of the Stević–Sharma operator from a general class X of holomorphic function spaces into Zygmund‐type spaces with some of the most convenient test functions on the open unit disk. As an application, we show that our results hold up for several other domain spaces of , such as the Hardy space and the weighted Bergman space.
An Index System for Learning Assessment in Higher Education: Case Study of the Sichuan University of Arts and Sciences
Authors: Lei Gang
Published: May 2022

With the development of education informatization, smart devices are being widely used in teaching, which has triggered significant changes in higher education. College students’ learning reflects the cognitive characteristics of digital natives, but their learning attitude and motivation have not significantly improved. Meanwhile, learning assessment in higher education is mostly based on the traditional assessment system, which has only a single index, a simple process, and mundane goals for learning assessment, thus making it difficult to effectively promote students’ learning. The present study, therefore, constructed an assessment index system using a pressure–state–response (PSR) model, gathered data using a questionnaire, and processed the data using SPSS and Amos. The results suggest that learning assessment in higher education should use a process assessment strategy and that the assessment system should be composed of three parts: classroom assessment, after-class assessment, and assessment evaluation. This type of all-round assessment can serve to effectively promote students’ learning. In addition, assessment evaluation should focus on students’ goals regarding their ability to innovate and reduce the weight of goals related to knowledge and skills while also giving teachers more adjudication power in assessment.
Study on the Function and Mechanism of miR-585-3p Inhibiting the Progression of Ovarian Cancer Cells by Targeting FSCN1 to Block the MAPK Signaling Pathway
Authors: Jia Yiming , Li Jingru , Wang Jinfeng , Luo Tianjiao , Jing Xiaoqian , Zhao Hongmin
Published: May 2022

Ovarian cancer (OC) is the leading cause of death for women diagnosed with gynecological cancer. Studies have shown that dysregulated miRNA expression is related to various cancers, including OC. Here, we aimed to explore the biological function and mechanism of miR-585-3p in the occurrence and development of OC. The expression level of miR-585-3p was found to be low in OC tissues and cells. We analyzed the biological function of miR-585-3p in OC through in vitro cell experiments. The results indicated that overexpression of miR-585-3p inhibited the proliferation, invasion, and migration of SW626 cells, while low expression of miR-585-3p had the opposite effect in SKOV3 cells. We then screened the target genes of miR-585-3p through miRDB database and detected the expression of target genes in OC cells. FSCN1 was found to be most significantly upregulated in OC cells. Dual-luciferase reporter assays revealed FSCN1 as a potential target of miR-585-3p. Western blot analysis showed that miR-585-3p targeted FSCN1 to inhibit protein phosphorylation of ERK. In vivo animal experiments also confirmed that miR-585-3p targets FSCN1 to inhibit tumor growth and block the MAPK signaling pathway. In summary, miR-585-3p inhibits the proliferation, migration, and invasion of OC cells by targeting FSCN1, and its mechanism of action may be achieved by inhibiting the activation of the MAPK signaling pathway. miR-585-3p may serve as a potential biomarker and therapeutic target for OC.
A Potential Prognostic Marker PRDM1 in Pancreatic Adenocarcinoma
Authors: Zhou Bo , Zhang Jie , Zhu Hongda , Wu Shugeng
Published: May 2022

Pancreatic adenocarcinoma (PAAD) is a major threat to people’s health. PRDM1 is a transcription factor with multiple functions, and its functions have been validated in a variety of tumors; however, there are few studies reported on PRDM1 in PAAD. Using the GEPIA2 database, this research found that PRDM1 expression in PAAD was significantly higher than that in normal pancreatic tissue. The Kaplan-Meier Plotter database showed that high expression of PRDM1 in PAAD has a poor prognosis, suggesting that PRDM1 may be a potential prognostic marker in PAAD. The cBioPortal database shows that the expression of PRDM1 in PAAD is significantly correlated with its methylation degree. Further analysis on the coexpressed genes of PRDM1 in PAAD was performed by using LinkedOmics database to explore potential mechanisms. Based on gene enrichment analysis, PRDM1 was implicated in many pathways involved in tumor progression. In the construction of a PPI network of PRDM1 and its coexpressed gene protein via the STRING database, we found that PRDM1 may be involved in the pathogenesis and development of PAAD. TIMER database suggested that a high level of PRDM1 has a significant positive correlation with macrophages, neutrophils, and DCs. Potential methylation sites of PRDM1 were found through DNMIVD database, and MethSurv database explored eight sites which were significantly related with the prognosis of PAAD. In conclusion, PRDM1 may work as a prognostic marker or even provide a potential therapeutic strategy in PAAD.
Comprehensive Analysis of PDLIM3 Expression Profile, Prognostic Value, and Correlations with Immune Infiltrates in Gastric Cancer
Authors: Hu Xinpeng , Chen Minfeng , Ruan Qiang , Shi Changzheng , Pan Jinghua , Luo Liangping
Published: May 2022

Protein PDZ and LIM domain 3 (PDLIM3) is a cytoskeletal protein, colocalizing with α-actinin on the Z line of mature muscle fibers. It plays a key role in dilated cardiomyopathy (DCM), muscular dystrophy, and tumor progression. However, correlations between PDLIM3 expression, prognosis, and tumor-infiltrating immune cells in gastric cancer are unknown. Therefore, we leveraged the Oncomine, GEPIA, GEO, and HPA databases to evaluate PDLIM3 expression in tumors. We also quantified PDLIM3 expression in 15 matched pairs of gastric tumor and nontumor tissues by immunohistochemistry. The Kaplan-Meier method was employed to determine the relationship between PDLIM3 expression and clinical outcomes. GO and KEGG analyses were performed to illuminate the molecular mechanisms of action of PDLIM3. TIMER2.0 and GEPIA were applied to investigate correlations between PDLIM3 expression and gene marker subsets signifying immune infiltration, with TIMER2.0 exploring the correlations between PDLIM3 and related signaling pathways. Gastric cancer tissues were found to express more PDLIM3 than nontumor tissues. PDLIM3 overexpression was associated with shorter OS and PFS of gastric cancer patients (OS

HR
=
2.02

,

P
=
9.8
e
−
10

; PFS

HR
=
1.77

,

P
=
7.5
e
−
06

). PDLIM3 was also positively correlated with worse OS and PFS according to gastric cancer staging, Her-2 overexpression, differentiation grade, and Lauren classification. PDLIM3 was shown to be associated with immunological responses by GO, while it was related to PI3K/Akt signal pathways by KEGG analysis. Furthermore, increased PDLIM3 expression was significantly correlated with greater infiltration of CD4+ T cells, CD8+ T cells, macrophages, neutrophils, and dendritic cells. PDLIM3 expression had significant positive correlations with a variety of immune marker subsets. Finally, correlations were found between PDLIM3 and crucial markers of signaling pathways involving PI3K/Akt and p38 MAPK. Thus, upregulation of PDLIM3 was significantly associated with poor prognosis, immune cell infiltration, and activation of two key signal pathways in gastric cancer. We propose that PDLIM3 could be used as a biomarker to predict prognosis and immune cell infiltration in gastric cancer.
Wavelet Sparse Coding-Based Lightweight Networks for Image Superresolution
Authors: Wang Bowei
Published: May 2022

Image superresolution (ISR) is a hot topic. With the success of deep learning, the convolutional neural network-based ISR makes great progress recently. However, most state-of-the-art networks contain millions of parameters and hundreds of layers. It is difficult to apply models realistically. To solve this problem, we propose a Wavelet Sparse Coding-based Lightweight Network for Image Superresolution (WLSR). Our contributions include four aspects. Firstly, to improve the ISR performance, the WLSR utilizes the superiorities of wavelet sparse coding on ISR. Secondly, we take advantage of the dilated convolution to expand receptive fields. In this case, the filters in WLSR can acquire more information than common convolutional filters from input images. Thirdly, to deal with sparse code efficiently, we employ deformable convolution networks to obtain the convolutional kernels that concentrate on nonzero elements. Fourthly, to make WLSR uint8 quantization robust, we take advantage of the Clipped ReLU activation in the end of WLSR and balance the SR performance with running time. Experimental results indicate that, compared with state-of-the-art lightweight models, the WLSR can achieve exceptional performance with few parameters. Moreover, the WLSR contains 30 times fewer parameters than VDSR, but it works better than VDSR on the validation set.
Clinicopathological Characteristics of Nonfunctional Pancreatic Neuroendocrine Neoplasms and the Effect of Surgical Treatment on the Prognosis of Patients with Liver Metastases: A Study Based on the SEER Database
Authors: Sadula Abuduhaibaier , Li Gang , Xiu Dianrong , Ye Chen , Ren Siqian , Guo Xin , Yuan Chunhui
Published: May 2022

Background. The incidence of nonfunctional pancreatic neuroendocrine neoplasms (NF-pNENs) has been increasing annually. This study is aimed at investigating the clinicopathological characteristics and high-risk factors of NF-pNENs and the influence of surgical treatment on the prognosis of NF-pNEN patients with liver metastases. Methods. pNEN patients in this study were obtained from the Surveillance, Epidemiology, and End Results (SEER) database. This study analyzed patients diagnosed with NF-pNENs from 2000 to 2017 who met the inclusion criteria. A retrospective analysis of the clinicopathological characteristics of NF-pNEN patients was conducted. Kaplan-Meier method was used to calculate the survival time. A multivariate Cox regression model was used to analyze the survival outcomes and risk factors. Results. From 2000 to 2017, the SEER database registered 10576 patients with pNENs and 1774 patients with liver metastases. Cox analysis revealed that age, sex, primary site, grade, tumor stage, surgery, tumor size, and liver metastasis were risk factors of prognosis, with grade being the most influential index. Patients with NF-pNENs with liver metastasis and no metastasis had different primary site, grade, and tumor size. In general, a higher grade was associated with a larger tumor and a greater risk of liver metastasis. Meanwhile, patients with liver metastasis showed that those with tumors originated from the tail of the pancreas had better prognoses than those with tumors originated from other parts. Surgical treatment can improve the prognosis of patients with liver metastases, despite the tumor grade. Conclusions. The incidence of pNENs has been increasing annually, and the liver has been the most common site of metastasis. Liver metastasis in patients with NF-pNENs, related to tumor size and grade, affected their long-term survival. Surgery significantly improved the prognosis of patients with liver metastases secondary to NF-pNENs with different grades.
Characteristic Evolution of GO/SBS‐Modified Asphalt during Aging
Authors: Li Zuzhong , Chen Weixi , Li Yuan , Liu Huijie , Zhao Zepeng , Cao Lan
Published: May 2022

Styrene‐butadiene‐styrene (SBS)‐modified asphalt has been widely used in high‐grade pavement due to its excellent road performance. However, environmental factors will lead to continuous deterioration of SBS‐modified asphalt; thus, it is difficult for asphalt pavement to meet the demands of long‐term service. In recent years, graphene oxide (GO) has attracted the attention of scholars due to its excellent compatibility and modification effect when used as an asphalt modifier. Based on previous studies, this study explored the characteristic evolution of GO/SBS composite‐modified asphalt during aging. To achieve this goal, GO and the SBS polymer were blended to prepare GO/SBS composite, which was then used to prepare the modified asphalt. Pure SBS and the GO/SBS composite were investigated by gel permeation chromatography (GPC), Fourier transform infrared spectroscopy (FTIR), and thermogravimetry (TG). In addition, the GO/SBS‐modified asphalt and SBS‐modified asphalt were studied by FTIR, fluorescence microscope (FM), dynamic shear oscillatory (DSR) test, and multiple‐stress creep recovery (MSCR) test. The results indicated that the incorporation of GO inhibited the deterioration of the asphalt binder and relieved the degradation of the SBS modifier during the thermo‐oxidative aging and photo‐oxidative aging processes. Based on the results extracted from the curves of the original samples in the FTIR analysis, it was concluded that GO was combined by physical blending in SBS and SBS‐modified asphalt. The TG test results verified that the GO powder could ameliorate the thermal stability of SBS. Moreover, GO improved the antirutting performance of the original SBS‐modified asphalt, while the GO/SBS‐modified asphalt had relatively poorer antirutting performance compared to the SBS‐modified asphalt after the same aging tests. The reason was that the increment of antirutting performance of asphalt binder by aging process was inhibited by GO.
The Optimization of Path Planning for Express Delivery Based on Clone Adaptive Ant Colony Optimization
Authors: Zhang Yao , Liu Yan , Li Chaoqun , Liu Yang , Zhou Jie
Published: May 2022

In recent years, China's express delivery market has developed rapidly in the context of a booming economy. However, logistics costs are still high, which will affect the decision-making and policy making of relevant departments. Therefore, it is essential to optimize the last-mile assignment problem (LMAP) to meet the consumer’s demand for delivery time and reduce economic expenditure. The LMAP of express delivery requires multiple packages to be delivered to different destinations. Finding the path with the minimum delivery cost and time is an NP-hard problem, and it is impossible to obtain the optimal solution by enumerating all possible answers. This study proposes a new express delivery path planning method based on a clone adaptive ant colony optimization (CAACO) to find suboptimal solutions. Moreover, a new distribution cost fitness function constructed by weighing the economic expenditure and time of express delivery is designed. Specifically, a new adaptive operator and a novel clone operator are also designed to accelerate the speed of convergence. Finally, by comparing the performance of CAACO with ant colony optimization (ACO), simulated annealing (SA), and genetic algorithm (GA), the effectiveness of CAACO in solving the express LAMP is verified. In the simulation results, it is obvious that the economic expenditure and time of express delivery based on the CAACO are lower than ACO, SA, and GA, and the convergence speed is also faster than the SA and GA. It can be seen that CAACO has valuable benefits in solving LMAP.
Exploring the Association between Glutathione Metabolism and Ferroptosis in Osteoblasts with Disuse Osteoporosis and the Key Genes Connecting them
Authors: Wang Yuanlin , Jia Yiming , Xu Yujing , Liu Xingkun , Wang Zheng , Liu Yang , Li Bing , Liu Jun
Published: May 2022

Disused osteoporosis is a kind of osteoporosis, a common age-related disease. Neurological disorders are major risk factors for osteoporosis. Though there are many studies on disuse osteoporosis, the genetic mechanisms for the association between glutathione metabolism and ferroptosis in osteoblasts with disuse osteoporosis are still unclear. The purpose of this study is to explore the key genes and other related mechanism of ferroptosis and glutathione metabolism in osteoblast differentiation and disuse osteoporosis. By weighted gene coexpression network analysis (WGCNA), the process of osteoblast differentiation-related genes was studied in GSE30393. And the related functional pathways were found through the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis. By combining GSE1367 and GSE100933 together, key genes which were separately bound up with glutathione metabolism and ferroptosis were located. The correlation of these key genes was analyzed by the Pearson correlation coefficient. GSTM1 targeted agonist glutathione (GSH) selected by connectivity map (CMap) analysis was used to interfere with the molding disused osteoporosis process in MC3T3-E1 cells. RT-PCR and intracellular reactive oxygen species (ROS) were performed. Two important pathways, glutathione metabolism and ferroptosis pathways, were found. GSTM1 and TFRC were thought as key genes in disuse osteoporosis osteoblasts with the two mechanisms. The two genes have a strong negative correlation. Our experiment results showed that the expression of TFRC was consistent with the negative correlation with the activation process of GSTM1. The strong relationship between the two genes was proved. Glutathione metabolism and ferroptosis are important in the normal differentiation of osteoblasts and the process of disuse osteoporosis. GSTM1 and TFRC were the key genes. The two genes interact with each other, which can be seen as a bridge between the two pathways. The two genes participate in the process of reducing ROS in disuse osteoporosis osteoblasts.
Animation Expression Control Based on Facial Region Division
Authors: Zhang Liangjun
Published: May 2022

Science and technology are developing rapidly in the twenty-first century. With the development of information technology, computers play a great role in people’s life. At present, with people’s increasing love for animation, exquisite and realistic animation has become people’s pursuit goal. Generally speaking, the most impressive thing in animation is the animation character expression. Nowadays, with the rapid development of science, it is necessary to develop a computer technology that can be used in animation expression control technology. The facial division is just met by computer technology. It is very important for the animation to create an animation expression consistent with the character’s face. The character face has diversity and uniqueness, which plays an important role in animation expression control. There are many factors in the character’s face area that affect animation expression control. The coordinated movement of multiple facial organs shows various emotional states through the changes in muscle movements in various areas of the face, such as eye muscles, facial muscles, and oral muscles. It has strong integrity and particularity and has relatively high technical requirements. Generally, the expression control technology can transform and deform a specific area of the face. Based on the division of the face area, the computer technology is used to calculate the different expression features of the face for recognition, showing a more exquisite and realistic animation expression. Under this background, this paper divides the facial region and introduces the physiological structure of the face and the relationship and influence between facial expression and animation expression control. Several algorithms used in facial structure feature point extraction are compared experimentally. After experimental comparison, it is found that the improved algorithm is much more efficient than the original algorithm in the process of extracting facial feature points, can remove redundancy, greatly reduce the amount of operation data, and lay a good foundation for the follow-up animation expression control technology.
Intelligent Control System of Unmanned Vehicle Based on CAN Controller
Authors: Wu Jinhua , Jiang Yunfei , Deng Fang
Published: May 2022

In order to enable the driverless vehicle formation controller to automatically control the driving of the fleet, an intelligent driverless vehicle control system based on the CAN controller is proposed. Expansion convolution of different expansion rates is used to obtain multi-scale target information and to fuse the feature information at different scales during upsampling to enrich the semantic information. Finally, the driverless CAN bus communication platform was established, the driverless monitoring interface was developed, and the software program was written; experiments on the steering control, speed control, voltage, current, speed, and angular speed acquisition, respectively, were performed. The experimental results show that the average semantic segmentation accuracy of the obstacles in concentrated vehicles, pedestrians, and bicycles reached 84.6%, and the detection and segmentation accuracy of the models was good. Therefore, the unmanned intelligent vehicle control system designed in this paper can meet the performance requirements of the vehicle control. No matter whether the given desired path is a straight line or a curve, the unmanned car can complete the path tracking control quickly, stably, and accurately.
Development and Validation of Nomogram-Based Prognosis Tools for Patients with Extremity Osteosarcoma: A SEER Population Study
Authors: Huang Yingtao , Wang Chenchen , Tang Dadong , Chen Bing , Jiang Zhongchao
Published: May 2022

Objective. Osteosarcoma, usually occurring in the extremities, is the most common malignant bone tumour. The purpose of this study is to develop and validate nomogram-based prognosis tools for survival (OS) and cancer special survival (CSS) of patients with osteosarcoma of the extremities via the application of survival analysis. Materials and Methods. A total of 1427 patients diagnosed with osteosarcoma of the extremities during 2004–2015 were selected from the National Cancer Institute’s (NCI) Surveillance, Epidemiology, and End Results- (SEER-) Medicare database. The samples were randomly assigned to either the training set (

n
=
856

) or the validation cohort (

n
=
571

). Kaplan–Meier (K–M) survival analysis was conducted to calculate patients’ 1-, 3-, and 5-year OS and CSS rates. Cox proportional hazard ratio (HR) regression models were employed to identify and examine the factors that have a significant impact on OS and CSS with data from the training cohort. Results. The results of univariate and multivariate analyses performed in the training cohort indicated that older age, increased tumour size, higher grade, distant tumour extension, amputation, or no surgery (all

HR
>
1

,

P
<
0.05

) were risk predictors of poor OS and CSS. Subsequently, the independent prognosis signatures were utilised to construct nomograms. The concordance index (C-index), calibration plot, and decision curve analysis (DCA) were simultaneously used to validate the nomograms. The internally validated C-index values of the OS and CSS prediction models for the training set were 0.752 (95% confidence interval [CI]: 0.738–0.765) and 0.754 [95% CI: 0.740–0.768], respectively. Then, the models were validated in the validation cohort population, which also demonstrated the models had good reliability for prognostication. Conclusions. The SEER cohort of patients with osteosarcoma of the extremities can be employed to produce effective tools that can assist in prognosis modelling.
Examining and Expanding the Expectancy Disconfirmation Model: Evidence from Rural China
Authors: Wang Peng , Fan Fengchun
Published: May 2022

In public management research, the Expectancy Disconfirmation Model (EDM) is increasingly used to measure citizen satisfaction. However, current EDM research in the public sector has been applied primarily in the United States and sets of the city, state, federal, or local government services. It leaves the validity of EDM for other levels and countries of government services to be verified. This study tests and extends the EDM by comparing it with previous studies and adding additional expectation priors to the model. Analysis of survey data from 313 citizens in 6 rural communities in China indicates that the basic model functions well in rural public services. In addition, the study of the extended EDM shows significant relationships between trust, service awareness, bureaucratic responsiveness, and expectations, which suggests new directions for future research using the model.
A Note on q‐Analogues of Degenerate Catalan‐Daehee Numbers and Polynomials
Authors: Khan Waseem A.
Published: May 2022

Recently, Yuankui et al. (Filomat J. 35 (5):17, 2022) studied q‐analogues of Catalan‐Daehee numbers and polynomials by making use of p‐adic q‐integrals on ℤp. Motivated by this study, we consider q‐analogues of degenerate Catalan‐Daehee numbers and polynomials with the help of p‐adic q‐integrals on ℤp. By using their generating function, we derive some new relations including the degenerate Stirling numbers of the first and second kinds. Moreover, we also derive some new identities and properties of this type of polynomials and numbers.
Combined Effects of Diabetes and Education on Decline of Cognitive Performance in the Older Population: The Survey of Health, Ageing, and Retirement in Europe
Authors: Kowall Bernd , Rathmann Wolfgang
Published: May 2022

Aims: Diabetes management requires cognitive abilities. Unfortunately, diabetes is a risk factor for cognitive decline. However, the effects of diabetes in persons with reduced cognitive reserves are unclear. We aimed to examine whether the effects of diabetes and education on cognitive skills simply add up or deviate from simple additivity. Methods: We used data from waves 1 to 7 (except wave 3) of the Survey of Health, Ageing, and Retirement in Europe (SHARE) collected between 2004 and 2017. SHARE includes 140,000 persons aged ≥50 years from 28 European countries and Israel. Diabetes was assessed by self-report and education was coded according to the International Standard Classification of Education levels. Verbal fluency, immediate, and delayed memory were assessed using standard tests. Interaction between diabetes and education was estimated from interaction contrasts and from interaction terms in adjusted regression models. Results: At baseline, cognitive performance declined in the order “no diabetes/high education” > “diabetes/high education” > “no diabetes/low education” > “diabetes/low education” for all three tests – e.g., the first group named 21.4 ± 7.2, the fourth group 14.6 ± 6.1 animals in a minute in the test of verbal fluency. Interaction contrasts and regression coefficients of interaction terms were close to zero, showing that the effects of diabetes and education on cognitive performance added up without interaction both in cross-sectional and longitudinal analyses. Conclusion: We have observed no interaction between education and diabetes on cognitive skills. Yet, people with diabetes and low education showed poor cognitive performance and should receive particular support in managing diabetes.
The Association between Migraine and Fetal-Type Posterior Cerebral Artery in Patients with Ischemic Stroke
Authors: Zhang Yi , Huang Xianjun , Cheng Huixian , Guo Hongquan , Yan Bin , Mou Tao , Xu Wei , Xu Gelin
Published: May 2022

Objective: The aim of the study was to determine if migraine is associated with fetal-type posterior cerebral artery (PCA) in patients with ischemic stroke. Method: In this cross-sectional study, patients with acute ischemic stroke were enrolled from two hospitals. The history of migraine headache was evaluated during a face-to-face interview. The variants of fetal-type PCA were assessed with MRA, CTA, or DSA. Patients with and without migraine were compared in terms of fetal-type PCA status and other clinic characteristics. Multivariate logistic regression analyses were performed to adjust for confounders and provide risk estimates for observed associations. Result: In 750 patients qualified for analysis, 85 (11.3%) were determined with migraine. Patients with migraine had a higher proportion of female gender (51.8% vs. 31.0%, p < 0.001), hypertension (72.9% vs. 57.7%, p = 0.007), and fetal-type PCA (36.5% vs. 20.1%, p = 0.001), while lower proportion of current smoking (25.9% vs. 38.3%, p = 0.025) than patients without migraine. National Institutes of Health Stroke Scale (NIHSS) score (3 vs. 2, p = 0.016) was also higher in migraineurs than in non-migraineurs. After adjustment for confounders, fetal-type PCA status was independently associated with migraine (odds ratio [OR] = 2.06; 95% confidence interval [CI], 1.25–3.38; p = 0.005). Other factors associated to migraine included female gender (OR = 2.03; 95% CI, 1.13–3.62; p = 0.017), hypertension (OR = 1.97; 95% CI, 1.17–3.34; p = 0.011), and NIHSS score (OR = 1.08; 95% CI, 1.01–1.16; p = 0.018). Conclusion: Migraine was associated with fetal-type PCA in patients with ischemic stroke. This finding supported the hypothesis that vascular mechanisms get involved in the migraine-stroke association.
Efficacy of Subantimicrobial, Modified-Release Doxycycline Compared to Regular-Release Doxycycline for the Treatment of Hidradenitis Suppurativa
Authors: Kontochristopoulos Georgios , Tsiogka Aikaterini , Agiasofitou Efthymia , Kapsiocha Anastasia , Soulaidopoulos Stergios , Liakou Aikaterini I. , Gregoriou Stamatios , Rigopoulos Dimitrios
Published: May 2022

Introduction: Antibiotics are frequently used to treat hidradenitis suppurativa (HS), but the evidence-based literature available on their use is limited. Considering that HS is not primarily an infectious disease, we sought to evaluate the efficacy of subantimicrobial, modified-release doxycycline (MR-DC) compared to regular-release doxycycline (RR-DC) for the treatment of HS. Materials and Methods: Patients were randomly assigned to receive treatment with either MR-DC 40 mg once daily or RR-DC 100 mg twice daily for a period of 12 weeks. The treatment efficacy was assessed after 12 weeks of treatment using the International Hidradenitis Suppurativa Severity Score System (IHS4), the Dermatology Life Quality Index (DLQI), and the Hidradenitis Suppurativa Clinical Response (HiSCR). Results: A total of 49 patients (25 in the MR-DC group and 24 in the RR-DC group) were included in the study. A statistically significant (p < 0.05) reduction of IHS4 and DLQI was observed in both groups at week 12. HiSCR was achieved by 64% of patients receiving MR-DC and 60% of those receiving RR-DC. Conclusion: MR-DC demonstrated comparable efficacy to RR-DC in the treatment of HS. MR-DC may serve as a valuable alternative to other antibiotic regimes, considering its anti-inflammatory properties and its lower potential to induce antibiotic resistance.
Treatment Practices and Confidence in the Management of Pediatric Metabolic Bone Disorders
Authors: McCutcheon Emma , Bowden Sasigarn A. , Wasserman Halley , Diaz-Thomas Alicia , Bijelić Vid , Bachrach Laura K. , Robinson Marie-Eve
Published: May 2022

Introduction: Pediatric metabolic bone and mineral disorders encompass a wide variety of disorders that can be challenging to diagnose and treat because of inadequate physician training about optimal management. Methods: As practice variation and confidence levels may impact clinical outcome, we sought to assess physician confidence in managing pediatric metabolic bone and mineral disorders and the spectrum of treatment practices among members of the Pediatric Endocrine Society (PES) and the Canadian Pediatric Endocrine Group (CPEG). Questionnaires were distributed via e-mail to all members of the PES and CPEG and 244 were completed. Responses were summarized using descriptive statistics, and proportions were compared using χ2 or Fisher’s exact tests, as appropriate. Results: Variations were observed among the respondents’ confidence in the management of bone disorders and in the criteria used to initiate/discontinue intravenous bisphosphonates or prescribe burosumab therapy. Respondents felt confident with the management of 4 out of 20 pediatric bone conditions (confidence was defined as >90% of respondents reporting feeling “somewhat confident” or “very confident”). Physicians working in a bone clinic were more confident in prescribing burosumab for the treatment of X-linked hypophosphatemic rickets compared to those not working in a bone clinic (65% vs. 47%, p = 0.03). Most respondents (52%) reported having received inadequate training in pediatric metabolic bone and mineral disorders. Discussion/Conclusion: Dedicated training, knowledge acquisition, and education resources are needed to increase confidence and standardize the use of bone-targeted therapies.
A educação de adultos como socialização: Hannah Arendt versus Paulo Freire
Authors: Whitaker Dulce Consuelo Andreatta , Souza Marinaldo Fernando de
Published: May 2022

Este texto analisa dados sob referenciais teóricos diametralmente oposto. Estimulados pela repentina e recente popularidade de Hannah Arendt, resolvemos submeter os dados de uma dissertação já defendida a um “novo” referencial, extraído do famoso texto de Arendt sobre a crise da educação nos Estados Unidos nos anos 1950. Os dados haviam sido interpretados à luz da epistemologia de Paulo Freire. Em novas análises, a partir de Arendt, nossas interpretações ganharam ainda mais força. No entanto, na comparação final entre os dois pensadores, destacam-se diferenças irreconciliáveis: Para Arendt, é impossível educar adultos e o mundo da educação deve ser desvinculado do mundo da política, já que a responsabilidade do educador se baseia na tradição e na autoridade, enquanto para Freire é possível sim educar adultos e a responsabilidade do educador – tal como em Sartre – leva à liberdade. Concluímos ser possível a educação social de adultos se, numa relação dialógica, nos educarmos com eles.
Estratégias de manutenção, acomodação e transposição do habitus em um cenário de mudanças
Authors: Souza Roger Marchesini de Quadros
Published: May 2022

Tendo como pano de fundo a implantação na rede pública estadual paulista do Regime de Ciclos com Progressão Continuada, privilegiando os conceitos de habitus, capital cultural e autoridade pedagógica de Pierre Bourdieu, este artigo analisa o depoimento de quatro professores de escolas públicas, com ênfase nos elementos referentes às reações e estratégias desenvolvidas para superar os impasses provocados por esta reforma educacional. Tendo este referencial de análise, busca-se constatar nos depoimentos o impacto, e contradições, que a referida reforma suscitou no habitus e no capital cultural dos professores, assim como as estratégias de superação dos conflitos que os docentes desenvolvem. Esta identificação é possível a partir do reconhecimento dos principais elementos que se expressam nos discursos dos professores e que revelam seu capital cultural, habitus docente e estratégias de superação dos conflitos surgidos com a implantação da referida reforma.
Variation in Cardiac Rehabilitation Participation During Aortic Valve Replacement Episodes of Care
Authors: Guduguntla Vinay , Yaser Jessica M. , Keteyian Steven J. , Pagani Francis D. , Likosky Donald S. , Sukul Devraj , Thompson Michael P.
Published: May 2022

Background:

Despite reported benefit in the setting of aortic valve replacement (AVR), cardiac rehabilitation (CR) utilization remains low, with few studies evaluating hospital and patient-level variation in CR participation. We explored determinants of CR variability during AVR episodes of care: transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR).

Methods:

A cohort of 10 124 AVR episodes of care (TAVR n=5121 from 24 hospitals; SAVR n=5003 from 32 hospitals) were identified from the Michigan Value Collaborative statewide multipayer registry (2015–2019). CR enrollment was defined as the presence of a single professional or facility claim within 90 days of discharge: 93 797, 93 798, G0422, G0423. Annual trends and hospital variation in CR were described for TAVR, SAVR, and all AVR. Multilevel logistic regression was used to estimate effects of predictors and hospital risk-adjusted rates of CR enrollment.

Results:

Overall, 4027 (39.8%) patients enrolled in CR, with significant differences by treatment strategy: SAVR=50.9%, TAVR=28.9% (
P
<0.001). CR use after SAVR was significantly higher than after TAVR and increased over time for both modalities (
P
<0.001). There were significant differences in CR enrollment across age, gender, payer, and some comorbidities (
P
<0.05). At the hospital level, CR participation rates for all AVR varied 10-fold (4.8% to 68.7%) and were moderately correlated between SAVR and TAVR (Pearson
r
=0.56,
P
<0.01).

Conclusions:

Substantial variation exists in CR participation during AVR episodes of care across hospitals. However, within-hospital CR participation rates were significantly correlated across treatment strategies. These findings suggest that CR participation is the product of hospital-specific practice patterns. Identifying hospital practices associated with higher CR participation can help assist future quality improvement efforts to increase CR use after AVR.
On the Role of Memory Representations in Action Control: Neurophysiological Decoding Reveals the Reactivation of Integrated Stimulus–Response Feature Representations
Authors: Eggert Elena , Takacs Adam , Münchau Alexander , Beste Christian
Published: May 2022

Efficient response selection is essential to flexible, goal-directed behavior. Prominent theoretical frameworks such as the Theory of Event Coding and Binding and Retrieval in Action Control have provided insights regarding the dynamics of perception–action integration processes. According to Theory of Event Coding and Binding and Retrieval in Action Control, encoded representations of stimulus–response bindings influence later retrieval processes of these bindings. However, this concept still lacks conclusive empirical evidence. In the current study, we applied representational decoding to EEG data. On the behavioral level, the findings replicated binding effects that have been established in previous studies: The task performance was impaired when an event file had to be reconfigured. The EEG-decoding results showed that retrieval processes of stimulus–response bindings could be decoded using the representational content developed after the initial establishment of these stimulus–response bindings. We showed that stimulus-related properties became immediately reactivated when re-encountering the respective stimulus–response association. These reactivations were temporally stable. In contrast, representations of stimulus–response mappings revealed a transient pattern of activity and could not successfully be decoded directly after stimulus–response binding. Information detailing the bindings between stimuli and responses were also retrieved, but only after having been loaded into a memory system. The current study supports the notion that stimulus–response integration and memory processes are intertwined at multiple levels.