bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of a Legal Regulation Approach and Strategy of a Sharing Economy Based on Technological Change and Sustainable Development
Authors: Wu Zixi , Zhou Wen , Yu Aisi
Published: January 2023

Economic regulations for sustainable development improve sharing and sustainability through diverse approaches. Market changes, stock values, and investor ideas are taken into consideration to achieve high sustainability. Multiple points across regulations are mandatory for adaptable improvements. Considering this feature, a conservative regulation approach (CRA) using artificial intelligence (AI) is introduced. The proposed approach relies on convolutional learning to improve economic sharing and sustainability. This approach takes in market values and economic sharing factors to estimate stability. The stability is validated using recurrent knowledge and non-tractable regulations. The proposed method was trained using current economic sharing and restrictions were applied. The learning process was prepared based on the available sharing information and development recommendations. This training improvises the changes and adaptations necessary for development and sustainability in economic sharing scenarios. The proposed approach’s performance is validated through metrics recommendation, data analysis, sustainability features, and economic sharing ratio.
Technologies for the Preservation of Cultural Heritage—A Systematic Review of the Literature
Authors: Mendoza María Antonia Diaz , De La Hoz Franco Emiro , Gómez Jorge Eliecer Gómez
Published: January 2023

This work establishes the technological elements that have enabled the preservation, promotion, and dissemination of tangible and intangible cultural heritage in the period from 2018 to 2022. For this, a Systematic Literature Review (SLR) was conducted in the scientific databases Scopus, Science Direct, IEEE and Web of Science, which facilitated the identification of 146 articles related to the topic. A quantitative and qualitative analysis of the journals, authors and topics was carried out, detailing the important variables required to establish the sought-out elements; for this purpose, the following were quantified in the papers: type, topic, categorization, country, and language; in the publications, the type of heritage chosen, the place of the heritage and the type of intervention were investigated. The number of publications reporting the use of some type of technology was also identified, finding that 70% of them show a technological approach to preserve cultural heritage, while 30% refer to other types of interventions. The technologies reported to be used the most are 3D digital technologies (44% of those showing technological applications), augmented reality or virtual reality, henceforth AR/VR (15%).
Environmental Management Accounting Implementation Challenges and Supply Chain Management in Emerging Economies’ Manufacturing Sector
Authors: Mukwarami Silas , Nkwaira Chekani , van der Poll Huibrecht Margaretha
Published: January 2023

Environmental management accounting (EMA) implementation challenges within supply chain management systems (SCMSs) and environmental awareness in emerging economies should be addressed for sustainable development. Therefore, this study explores EMA implementation challenges in the supply chain in manufacturing to propose a framework to guide manufacturing companies to achieve a cleaner production chain. After conducting an extensive literature review on literature related to EMA in developing countries, challenges characterising EMA implementation have been identified. These include incoherent government policies and regulations; unavailability of resources; technological incapability; inadequate training and expertise; allocation of environmental costs; and environmental reporting. Hence, it is suggested that manufacturing companies must understand the financial and environmental benefits of achieving cleaner production through implementing EMA. Managers can make more environmentally friendly decisions based on their supply chain using the developed framework. Regulators may need key regulatory framework reforms and policies to monitor and assess environmental compliance throughout the supply chain. Longitudinal and quantitative data from manufacturing companies in developing countries are suggested to validate the existence of EMA implementation challenges.
Comprehensive Database Creation for Potential Fish Zones Using IoT and ML with Assimilation of Geospatial Techniques
Authors: Kimothi Sanjeev , Thapliyal Asha , Singh Rajesh , Rashid Mamoon , Gehlot Anita , Akram Shaik Vaseem , Javed Abdul Rehman
Published: January 2023

The framework for aqua farming database collection and the real-time monitoring of different working functions of aqua farming are essential to enhance and digitalize aqua farming. Data collection and real-time monitoring are attained using cutting-edge technologies, and these cutting-edge technologies are useful for the conservation and advancement of traditional aquatic farming, particularly in hilly areas with sustainable development goals (SDGs). Geo-tagging and geo-mapping of the aqua resources will play an important role in monitoring the species in the aquatic environment and can track the real-time health status, movement, and location, and monitor the foraging behaviors, of aquatic species. This study proposed an architecture with the IoT to manage the aqua resource for eco-sustainability with geospatial data. This study also discussed the geo information systems (GIS)- and geo positioning system (GPS)-based web-based framework for the fisheries sector and the creation of a database for aqua resource management. In the study, the results of database generation for the aqua resource management and the results of the fishpond in the cloud server are presented in detail. Machine learning (ML) is integrated with the framework to analyze the sensor data and geo-spatial data for the identification of any degradation in the water quality. This will provide real-time information to the policymakers for their critical decisions for the further development of aquatic species for enhancing the economy of the state as well as aqua farmers.
A Sustainable Location Model of Transshipment Terminals Applied to the Expansion Strategies of the Soybean Intermodal Transport Network in the State of Mato Grosso, Brazil
Authors: de Morais Gustavo Rodrigues , Calil Yuri Clements Daglia , de Oliveira Gabriel Faria , Saldanha Rodney Rezende , Andrey Maia Carlos
Published: January 2023

The transport system is one of the main bottlenecks of the world’s largest producer and exporter of soybeans, Brazil. Long-distance truck transportation of grains increases costs, food waste, and CO2 emissions. To handle these problems, the Brazilian government seeks to expand the transportation system through the national transport logistics plan (PNLT), promoting efficient operations. Collaborating on the environmental aspect, this paper proposes sustainable logistic infrastructure for soybean transportation. Investigating the largest grain-producing state in the world, Mato Grosso (Brazil), we show the optimal location for capacitated transshipment terminals untangling the relationship between logistics and sustainability. Besides handling cargo truck costs and CO2 emission, the optimization model considers cities, road distances, transshipment terminals existents, terminals capacities, implementing costs, and locations near waterways and railways. In five scenarios with different combinations of waterways and railways, we contrast the cost of installing terminals and the total road distance traveled under different weights for the environmental components. The results indicate that it is possible to simultaneously obtain the minimum cost of installing transshipment terminals and to reduce emissions by 20% in all analyzed scenarios. We conclude that obtaining strategic solutions at lower costs can be combined with proper environmental responsibility. As contributions, the results allow for advances in the area of sustainable logistics, encouraging the development of new research in Brazil involving the dimensions of sustainability. In addition, the study supports the government’s strategic decisions regarding ongoing discussions on expanding the intermodal soy transport network in the country.
Hydrological Analysis of Green Roofs Performance under a Mediterranean Climate: A Case Study in Lisbon, Portugal
Authors: Santos Maria Luíza , Silva Cristina Matos , Ferreira Filipa , Matos José Saldanha
Published: January 2023

In this paper, the hydrological performance of eight pilot green roofs (GR) installed in Lisbon, Portugal, under a Mediterranean climate is analyzed. The pilot units were installed at Instituto Superior Técnico campus of Lisbon University. The pilots present different plant species and different substrate types, with some of the units incorporating recycled construction and demolition waste (RCW). The green roofs pilots’ hydrologic performance was evaluated through the simulation of artificial precipitation events between March 2021 and July 2021. Considering the results obtained, it can be concluded that the inclusion of RCW in the substrate composition did not hinder the development of vegetation or the hydrological performance of GR. The results showed a rainfall water retention per event ranging from 37% to 100%, with an average rainfall retention of about 81%. The runoff delay ranged from 2 to 18 min, and the peak attenuation ranged from 30 to 100%. The results indicated that previous substrate moisture strongly influences the hydrological performance of GR. As the inclusion of RCW in the substrate composition promotes a more effective drainage of the substrate during dry conditions, it is considered that RCW may have positive impacts on GR’s hydrological performance.
Research on Design Strategy of Mask Recycling Service Based on Behavior Environment
Authors: Wu Yueqin , Zhang Hao , Zhang Miao
Published: January 2023

The global novel coronavirus pandemic has caused a surge in the use of masks worldwide. A large number of used masks that have not been properly handled enter the environment, which caused and will cause serious ecological problems. The purpose of this study is to propose a solution to the problem of mask management from the perspective of science of design, and to build a good mask recycling service design strategy through the combination of design and psychology. Firstly, based on the theory of behavioral environment and field investigation, this study analyzes the correlation between the existing mask recycling device and its recycling efficiency, user behavior psychology and environment, and studies the behavioral scene of mask recycling, and then establishes the center of design strategy implementation. Secondly, a visual guidance system is designed, as is a special recycling device for masks by color psychology and product design. Thirdly, combined with the concept of social innovation service design, the design of a mask recycling strategy is conceived, and the optimization and formulation of mask recycling strategy is demonstrated through stakeholders, user journey maps and service flow charts. Finally, the design strategy is hierarchically established, and the feasibility analysis system model of a mask recycling strategy design is constructed. The data collection is carried out through expert interviews and questionnaires, and the weight is calculated by a fuzzy analytic hierarchy process. The final output comprehensive evaluation results show that the mask recycling strategy constructed in this study has public recognition.
Efficacy of an Adaptive Learning System on Course Scores
Authors: Lim Lyndon , Lim Seo Hong , Lim Wei Ying Rebekah
Published: January 2023

Adaptive learning systems have gained popularity within higher education, given the affordances that claim to enhance student learning outcomes by providing personalised learning trajectories that allow students to interact with course content at their own pace. Nonetheless, studies investigating the impact of such systems on learning outcomes such as course scores have been mixed, in part due to the research approaches applied, as found by the review undertaken in this study. Yet, for purposes of accountability, it remains critical to investigate the efficacy of adaptive learning systems, at least for its relation to course scores when assessment stakes are involved. This study reports the efficacy of an in-house adaptive learning system used within an institution in terms of its impact on course scores, based upon propensity score analysis, a quasi-experimental approach considered as a feasible alternative to randomised controlled trials. Results of this study reported a difference in course scores, suggesting merit in using the in-house adaptive learning system, though the difference did not present statistically significant differences at the 95% confidence level. Directions for future research are also discussed.
Spatiotemporal Evolution and Determinants of the Geography of Chinese Patents Abroad: A Case Study of Strategic Emerging Industries
Authors: Zhai Chenyang , Du Debin , Shi Wentian
Published: January 2023

China’s rapid technological growth and aggressive globalization policies have led to an increasing interest in Chinese patents abroad. This study uses strategic emerging industries (SEIs) that are important for the future development of the world as examples and constructs a novel dataset of Chinese SEI patents abroad (1993–2017) to explore the spatiotemporal evolution and determinants of the geography of these patents. Our results show that the number of Chinese SEI patents abroad is growing rapidly, and the new-generation information technology industry is increasingly dominating, accounting for approximately 50% of all SEI patents abroad. Chinese SEI patents abroad are highly concentrated in the United States, Western Europe, and East Asia, and their influence is gradually spreading from African countries to developed countries. The host country’s intellectual property rights (IPR) protection level, technology market size and imitation risk have significant positive effects on Chinese SEI patents abroad, while the host country’s high-tech product market size and competition risk have negative effects on Chinese patents abroad. The conclusions provide new information for understanding Chinese patents abroad activities and the motivation of China’s technology globalization and provide evidence from an emerging country for research of the international diffusion of technology innovation.
Rapid Determination of Selected PFAS in Textiles Entering the Waste Stream
Authors: Drage Daniel Simon , Sharkey Martin , Berresheim Harald , Coggins Marie , Harrad Stuart
Published: January 2023

Due to new European legislation, products entering the waste stream containing some perfluoro alkyl substances (PFAS) are subject to “low persistent organic pollutant concentration limits”. Concentrations of restricted PFAS must be below this limit for them to be legally recycled or disposed of. A rapid extraction and clean-up method was developed for the determination of 21 PFAS in various polymers used in soft furnishings and upholstery. The optimised method used vortexing and ultrasonication in methanol (0.1% NH4OH), followed by a dilution and syringe filter clean-up step. PFAS were subsequently determined via UPLC-TripleTOF/MS. Good recoveries (80–120%) of target analytes were obtained with tall and narrow chromatogram peaks. The method was validated using control matrix samples spiked with target analytes. Repeated measurements of concentrations of target compounds showed good agreement with the spiked concentrations demonstrating good accuracy and precision. The resultant extracts provided low noise levels resulting in low limits of quantification ranging from 0.1 to 0.4 mg/kg. The developed method was applied successfully to real consumer products and it provided various advantages over traditional methods, including a substantially reduced analysis time, consumables and solvent consumption, and a high sample throughput which is critical to comply with implemented and proposed legislation.
Anti-Inflammatory Activity of 1,4-Naphthoquinones Blocking P2X7 Purinergic Receptors in RAW 264.7 Macrophage Cells
Authors: Kozlovskiy Sergei A. , Pislyagin Evgeny A. , Menchinskaya Ekaterina S. , Chingizova Ekaterina A. , Sabutski Yuriy E. , Polonik Sergey G. , Likhatskaya Galina N. , Aminin Dmitry L.
Published: January 2023

P2X7 receptors are ligand-gated ion channels activated by ATP and play a significant role in cellular immunity. These receptors are considered as a potential therapeutic target for the treatment of multiple inflammatory diseases. In the present work, using spectrofluorimetry, spectrophotometry, Western blotting and ELISA approaches, the ability of 1,4-naphthoquinone thioglucoside derivatives, compounds U-286 and U-548, to inhibit inflammation induced by ATP/LPS in RAW 264.7 cells via P2X7 receptors was demonstrated. It has been established that the selected compounds were able to inhibit ATP-induced calcium influx and the production of reactive oxygen species, and they also exhibited pronounced antioxidant activity in mouse brain homogenate. In addition, compounds U-286 and U-548 decreased the LPS-induced activity of the COX-2 enzyme, the release of pro-inflammatory cytokines TNF-α and IL-1β in RAW 264.7 cells, and significantly protected macrophage cells against the toxic effects of ATP and LPS. This study highlights the use of 1,4-naphthoquinones as promising purinergic P2X7 receptor antagonists with anti-inflammatory activity. Based on the data obtained, studied synthetic 1,4-NQs can be considered as potential scaffolds for the development of new anti-inflammatory and analgesic drugs.
Evaluation of Two Different Strategies for Schistosomiasis Screening in High-Risk Groups in a Non-Endemic Setting
Authors: Roade Luisa , Sulleiro Elena , Bocanegra Cristina , Salvador Fernando , Treviño Begoña , Zarzuela Francesc , Goterris Lidia , Serre-Delcor Nuria , Oliveira-Souto Inés , Aznar Maria Luisa , Pou Diana , Sánchez-Montalvà Adrián , Bosch-Nicolau Pau , Espinosa-Pereiro Juan , Molina Israel
Published: January 2023

A consensus on the recommended screening algorithms for schistosomiasis in asymptomatic high-risk subjects in non-endemic areas is lacking. The objective of this study was to evaluate the real-life performance of direct microscopy and ELISA serology for schistosomiasis screening in a high-risk population in a non-endemic setting. A retrospective cohort study was conducted in two out-patient Tropical Medicine units in Barcelona (Spain) from 2014 to 2017. Asymptomatic adults arriving from the Sub-Saharan region were included. Schistosomiasis screening was conducted according to clinical practice following a different strategy in each setting: (A) feces and urine direct examination plus S. mansoni serology if non-explained eosinophilia was present and (B) S. mansoni serology plus uroparasitological examination as the second step in case of a positive serology. Demographic, clinical and laboratory features were collected. Schistosomiasis cases, clinical management and a 24 month follow-up were recorded for each group. Four-hundred forty individuals were included. The patients were mainly from West African countries. Fifty schistosomiasis cases were detected (11.5% group A vs. 4 % group B, p = 0.733). When both microscopic and serological techniques were performed, discordant results were recorded in 18.4% (16/88). Schistosomiasis cases were younger (p < 0.001) and presented eosinophilia and elevated IgE (p < 0.001) more frequently. Schistosomiasis is a frequent diagnosis among high-risk populations. Serology achieves a similar performance to direct diagnosis for the screening of schistosomiasis in a high-risk population.
Cytopathic and Genomic Characteristics of a Human-Originated Pseudorabies Virus
Authors: Peng Zhong , Liu Qingyun , Zhang Yibo , Wu Bin , Chen Huanchun , Wang Xiangru
Published: January 2023

Pseudorabies virus (PRV) generally infects pigs and threatens the pig industry. However, recently we have isolated a PRV strain designated hSD-1/2019 from infected humans. In this study, we compared the complete genome sequence of hSD-1/2019 with those of pig-originated PRV strains. Sequence alignments revealed that the genome sequence of hSD-1/2019 was highly homologous to those of the porcine PRV strains. Phylogenetic analyses found that hSD-1/2019 was the closest related to porcine PRV endemic strains in China, particularly the variant strains circulating recently. We also showed that the glycoproteins important for the multiplication and pathogenesis of hSD-1/2019 were highly similar to those of the pig endemic strains. Diversifying selection analyses revealed that hSD-1/2019 and pig variant strains are under diversifying selection. Recombination analysis indicated that hSD-1/2019 was a recombinant of several PRV variant strains and an earlier PRV classic strain. Finally, we found that both human and pig-originated PRV strains could induce cytopathic effects in cells from humans, pigs, and mice, but only the human PRV and pig-variant PRV formed large syncytia in human cell lines. The data presented in this study contribute to our understanding of the molecular basis for the pathogenesis of human PRV from a genomic aspect.
Assessment of Antibody-Titer Changes after Second and Third Severe Acute Respiratory Syndrome Coronavirus 2 mRNA Vaccination in Japanese Post-Kidney-Transplant Patients
Authors: Fujieda Kumiko , Tanaka Akihito , Kikuchi Ryosuke , Takai Nami , Saito Shoji , Yasuda Yoshinari , Fujita Takashi , Kato Masashi , Furuhashi Kazuhiro , Maruyama Shoichi
Published: January 2023

Post-renal-transplant patients have a relatively low antibody-acquisition rate following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) mRNA vaccination. In this study, antibody titers were measured 5–6 months and 3 weeks to 3 months after the second and third SARS-CoV-2 mRNA vaccinations, respectively. Post-renal-transplant patients visiting our hospital who had received three SARS-CoV-2 mRNA vaccine doses were included in the study. SARS-CoV-2 immunoglobulin G antibody titers were measured three times: between 3 weeks and 3 months after the second vaccination, 5–6 months after the second vaccination, and between 3 weeks and 3 months after the third vaccination. A total of 62 (40 men and 22 women) were included, 44 of whom (71.0%) were antibody positive after their third vaccination. On comparing the antibody-acquired and antibody-non-acquired groups, body mass index (BMI, odds ratio [OR]: 1.44, 95% confidence interval [CI]: 1.07–1.93, p < 0.05) and the estimated glomerular filtration rate (eGFR, OR: 1.14, 95% CI: 1.06–1.24, p < 0.01) were associated with antibody acquisition. Therefore, in Japanese post-kidney-transplant patients, increases in the antibody-acquisition rate and absolute antibody titer after the third vaccination were observed, with BMI and eGFR associated with the antibody-acquisition rate.
Ecological and Human Health Risks of Metal–PAH Combined Pollution in Riverine and Coastal Soils of Southern Russia
Authors: Konstantinova Elizaveta , Minkina Tatiana , Mandzhieva Saglara , Nevidomskaya Dina , Bauer Tatiana , Zamulina Inna , Sushkova Svetlana , Lychagin Mikhail , Rajput Vishnu D. , Wong Ming Hung
Published: January 2023

The floodplains and seacoasts of southern Russia are characterized by urbanization, developed agriculture, and rapidly developing industries. Anthropogenic activity leads to the long-term release of pollutants into the environment, which threatens the stability of ecosystems and public health. The study aimed to assess the ecological and human health risks posed by potentially toxic elements (PTEs) and polycyclic aromatic hydrocarbons (PAHs) in the topsoils of the Taganrog Bay coast and the Lower Don floodplain. Concentrations of PTEs and PAHs were measured using X-ray fluorescence and high-performance liquid chromatography, respectively. Except for the comparatively most toxic Cd, which ranged from low to moderate, ecological risk factors indicated a low risk for PTEs. The cumulative ecological risk of PTEs was low. Zn, As, Cd, and benzo[a]pyrene (BaP) were the most dangerous pollutants, with concentrations 1–2 orders of magnitude higher than the maximum permissible concentrations (MPCs). Mostly sandy soils were characterized by high and very high individual pollution since they have more stringent quality standards due to their lower resistance to contamination. Significant concern is caused by the total contamination of soils with PAHs. A comparison of the toxic equivalent quotient of PAHs with the MPC of BaP showed high or very high contamination in two-thirds of the samples. The non-carcinogenic risk for adults in the region was negligible, whereas the risk for children was low. Dermal contact with PTEs and PAHs contributed to a significant non-carcinogenic risk. Only the combined intake of pollutants poses a substantial risk for children. Over most of the research area, total carcinogenic risk surpasses the threshold, indicating a low risk, with As being the most important contributor. The results of the study showed that PAHs pose a greater potential ecological risk than PTEs, and the opposite trend was observed in relation to the risk of negative impacts on human health. In this regard, taking into account the combined influence of different types of components allows for a more comprehensive risk assessments.
The Suppression of Modular Multi-Level Converter Circulation Based on the PIR Virtual Impedance Strategy
Authors: Wang Chun , Yan Wenxu , Wang Wenyuan , Ni Hongyu , Chu Jie
Published: January 2023

In recent years, with the rise of the electric vehicle industry, there has been significant research on charging and power supply vehicle technologies for electric vehicles. In terms of the corresponding converter usage, modular multi-level converters (MMCs) are also increasingly used in the field of electric vehicle power supply research because of their unique advantages. However, the circulating current problem of MMCs has not been effectively addressed in existing domestic and international studies. In this paper, we propose a proportional-integral resonant (PIR) control method combined with virtual impedance for the optimal suppression of the MMC internal circulating current problem based on the comparison and generalization of the existing methods. Based on the analysis of the working principle of MMCs, this paper proposes and adopts the control strategy of combining virtual impedance and proportional-integral resonance to suppress the circulating current and builds a simulation model in MATLAB to verify that the control strategy proposed in this paper is feasible.
Determinants of Depression, Anxiety, and Stress among Pregnant Women Attending Tertiary Hospitals in Urban Centers, Nigeria
Authors: Wegbom Anthony Ike , Edet Clement Kevin , Ogba Amaka Azubuike , Osaro Benjamin Osarolaka , Harry Agiriye M. , Pepple Biteegeregha Godfrey , Fagbamigbe Adeniyi Francis
Published: January 2023

Most times, pregnancy is considered a joyous event, but it also heightens a woman’s emotional and psychological state. Globally, some women suffer mental disorders, especially in developing nations. In Nigeria, there is evidence for a high prevalence of depression, anxiety, and stress during pregnancy. Therefore, this study aimed to estimate the severity and factors associated with depression, anxiety, and stress among pregnant women in Port Harcourt, Nigeria. A facility-based cross-sectional survey was carried out in the two tertiary hospitals in Port Harcourt city between September and October 2022 using the Depression Anxiety and Stress Scale-21 (DASS-21). Univariate, bivariate, and multivariate analyses were performed using STATA 16. The proportional odds model (POM) was used, and the statistical significance was set at p ≤ 0.05. A total of 413 respondents participated in the study, of whom 9.5%, 26.6%, and 17.3% had at least moderate depression, anxiety, and stress, respectively. Marital status, educational levels, and employment status were significantly associated with depression. Marital status, religion, and trimester were significantly associated with anxiety, while age, marital status, educational level, religion, income, trimester, and previous abortions/miscarriages were significantly related to stress. This study showed evidence of moderate-to-extremely severe anxiety, stress, and depression, as well as factors associated with these disorders. Our findings have implications for strengthening mental health policies as they pertain to antenatal care.
Recurrent Penicillin-Resistant Tonsillitis Due to Lactococcus garvieae, a New Zoonosis from Aquaculture
Authors: Mayo-Yáñez Miguel , González-Torres Lucía
Published: January 2023

Zoonotic diseases are a group of infectious diseases that are transmitted naturally from animals to humans. L. garvieae is a Gram-positive bacterium which is present in the aquaculture of freshwater and marine fish. Some isolated cases of infection have been described, considering it an opportunistic agent in immunosuppressed patients. The most recent appearance of severe infections in immunocompetent patients or colonizing cardiac prostheses has set off the alarms. This manuscript presents the first two patients with recurrent tonsillitis due to L. garvieae. A 15-year-old male and an 8-year-old male had recurrent tonsillitis with more than three episodes per year. A culture of tonsillar exudate in both cases showed growth of L. garvieae with an antibiogram showing multi-resistance to antibiotics. Given the parents’ wish not to carry out surgery, an autovaccine regimen with lysed bacteria was proposed with good evolution and remission of tonsillitis episodes in both cases. The oral autovaccine produces an immunomodulatory effect and could be a therapeutic weapon in the prevention of this zoonosis. Further studies are needed to determine the importance of foodborne transmission in human L. garvieae infections and to find suitable treatments for this wide range of infections.
Transformaciones en el desarrollo urbano de Manta, Ecuador: desde la ciudad colonial hasta la ciudad fragmentada
Authors: Samada Grasst Yanet
Published: January 2023

La expresión territorial y transformaciones en el desarrollo urbano de la ciudad de Manta en el Ecuador es una característica de la ciudad intermedia, que muestra un gran crecimiento demográfico, unido a un extraordinario consumo de suelo para usos urbanos, determinado por la vocación de puerto y ubicación estratégica. La presente investigación se direccionó en analizar las transformaciones en el desarrollo urbano de Manta, desde la ciudad colonial hasta la fragmentada. Para ello, fue necesario la aplicación de una metodología descriptiva, bajo un enfoque cualitativo a través del análisis documental en donde se identificó, revisó y clasificó de forma rigurosa la literatura especializada que permitió deducir el paso del modelo compacto y urbano polinuclear, propio de las fases iniciales de la investigación, al  disperso fragmentado y sectorial; sustentado en los ejes viales principales que son utilizados de manera poco homogénea en zonas periféricas, sin una adecuada planificación de las áreas de expansión que ha inducido a un crecimiento urbano fragmentado. Entre los principales hallazgos se identificó como la dinámica económica vinculada a las actividades portuarias, fabriles y pesca de exportación, supusieron la mayor expansión de la superficie urbana consolidando un patrón de baja densidad apoyado en los nuevos ejes viarios. El resultado es una ocupación dispersa, desordenada, claramente segregada y donde las escasas políticas urbanas han alentado la inversión inmobiliaria en las zonas mejor dotadas de equipamientos, servicios y conectividad.
RELEVANT FACTORS AND RESULTS OF TREATMENT IN WOMEN WITH PREMATURE RUPTURE OF MEMBRANES AT HUE UNIVERSITY OF MEDICINE AND PHARMACY HOSPITAL
Authors: Truong Thi Linh Giang , Ho Thi Khanh Linh
Published: January 2023

Abstract:
Objectives: To study clinical, subclinical features and to analyze treatment attitudes in patients with PROM. Materials and methods: A descriptive cross-sectional study, including 51 women with PROM at above 22 weeks’ gestation, from January 2020 to April 2021 at the Department of Obstetrics, Hue University of Medicine and Pharmacy Hospital. Results: Maternal mean age was 29.57 ± 5.38 years. The frequency of PROM in the primigravida (47.1%) was higher than the multigravida. Most patients were hospitalized without labour symptoms. There were insignificant differences in median white blood cell and amniotic fluid Index between < 37 and > 37 weeks group. The women that had cesarean in the < 37 and > 37 weeks group were 34.1% and 52.6%. There was a negative correlation between gestational age and duration time of PROM to delivery (r = 0.656; p = 0.000). The mean weight of gestation was 2634 ± 432 grams in the < 37 weeks group and 3152 ± 274 grams in > 37 weeks group. The sensitivities and specificities of level white blood cells (optimal cut-off was 10.59 x 109/L) for the diagnosis of chorioamnionitis were 90.2% and 52.5%. Chorioamnionitis was increased with the duration
of PROM to delivery > 48 hours (OR 8.4, 95% CI 1.85 – 38.01, p = 0.007). Linear regression analysis did not show the correlation between these factors: gestational age, cesarean delivery, chorioamnionitis and neonatal infection. Neonatal respiratory distress syndrome was increased with chorioamnionitis (OR 14.0, 95% CI 1.1 – 178.9, p = 0.014). Conclusion: Gestation’s age and relevant factors are associated with treatment attitudes and outcomes in patients with PROM. More research is needed with a larger sample size to clarify the statistical significance of difference.
Key words: Premature rupture of membranes (PROM), chorioamnionitis, newborn respiratory distress syndrome, neonatal infection
DEVELOPMENT OF CAPILLARY ELECTROPHORESIS METHOD FOR DETERMINATION OF&NBSP;AMLODIPINE IN HUMAN PLASMA
Authors: Nguyen Hong Anh , Tran Le Truong An , Nguyen Thi Nhu Ngoc
Published: January 2023

Abstract:
Background: Amlodipine, a calcium channel blocker, is commonly prescribed to treat high blood pressure. In Vietnam, there is no method of quantifying amlodipine in plasma by capillary electrophoresis. Therefore, the thesis was carried out with the objective: Developing and validating a method for quantifying amlodipine in human plasma by capillary electrophoresis. Materials and methods: Human plasma samples contain amlodipine. After optimizing the process, the method was validated according to the guidelines for validation of bioanalytical methods of US-FDA and EMA. Results: Amlodipine and nifedipine as internal
standard (IS) were alkalized with sodium hydroxide and extracted from human plasma by liquid - liquid extraction technique with ethyl acetate. Electrophoresis conditions: Fused-silica capillary column (effective column length: 48.5 cm, total column length 57.5 cm, outside diameter: 75 μm, internal diameter: 75 μm), background electrolyte: 50 mM borate buffer at pH 8.6 containing 20 mM sodium dodecyl sulfate, voltage: +25 kV, current: 300 μA, column temperature: 25 ± 1 oC, sample injection: 35 mBar - 7s, detection at 237 nm. The method was validated and met US-FDA and EMA requirements. Conclusion: The method can serve as a basis in bioequivalence studies of medicinal products containing amlodipine.
Key words: Amlodipin, human plasma, capillary electrophoresis
EPIDEMIOLOGICAL CHARACTERISTICS OF VARICELLA IN KON TUM PROVINCE IN 2018
Authors: Doan Vuong Diem Khanh , Nguyen Loc Vuong , Nguyen Thi Hong Nhi , Dang Cao Khoa
Published: January 2023

Abstract:
Background: In Vietnam, the number of people suffered from Varicella was high, accounting for 25.000 – 40.000 cases and children were dominant. In Kon Tum, the annual number of Varricella cases remains high, the average 5-year period from 2013-2017 was 779 cases per year. Objective: The study aimed to describe the epidemiological characteristics of Varicella in Kon Tum province in 2018. Methodology: The retrospective description was conducted among 368 Varicella patients in Kon Tum Province from January to December 2018. Data collection was based on the Varicella monthly reporting form of the Kon Tum Center for Disease Control. Results: The cumulative prevalance of Varicella/100.000 people was 68.8. The distribution of Varicella in region III was highest, accounting for 52.7%. The Varicella experienced all months of the year, and in March had the highest number of infectious cases, accounting for 51%. The cumulative prevalence of Varicella/100.000 people among women was 78.6, the figure for was 60,0. The incidence of Varicella/100.000 people in the group under 5 years old was the highest (286.6). The cumulative prevalemce of Varicella/100.000 people in ethnic minorities was nearly 3 times higher than that of the Kinh people. The
distribution of Varicella in young children accounted for the highest proportion (45.6%). Conclusion: There was a need in further strengthening health communication and education for people on preventing and controlling Varicella, especially for ethnic minorites.
Key words: epidemiological characteristics, varicella, Kon Tum, Vietnam
Incentivo à cultura maker no curso de Engenharia elétrica por meio de atividades extracurriculares
Authors: Cordeiro Leticia , Lolis Luis Henrique Assumpção
Published: January 2023

O conhecimento técnico sobre as tecnologias emergentes está se tornando cada vez mais necessário para a entrada dos estudantes de graduação em Engenharia no mercado de trabalho. Entretanto, não só o conhecimento técnico é requisitado, mas habilidades como criatividade para solução de problemas, conhecimentos interdisciplinares e adaptabilidade são importantes diferenciais. A cultura ou movimento maker, definido como a premissa de que os indivíduos podem realizar projetos e fabricações para uma finalidade específica em um ambiente de compartilhamento de conhecimento e ideias, surge como um facilitador para o estudante aprender a desenvolver essas habilidades. O conhecimento sobre softwares, novos equipamentos ou processos de fabricação não necessariamente estão presentes nas grades curriculares de ensino superior das universidades, desse modo, cria-se a necessidade de atividades extracurriculares que podem ser oferecidas pelos grupos do Programa de Educação Tutorial (PET), como forma de complementar a formação do futuro engenheiro e prepará-lo para os desafios do mercado de trabalho. Tendo isso em vista, o grupo PET Engenharia Elétrica da Universidade Federal do Paraná buscou formas de incentivar a cultura maker nos discentes e na comunidade externa. Foram realizadas formações técnicas para os membros do grupo, oferecidos cursos de modelagem em CAD e impressão 3D, além da prestação de serviços, como a impressão de arcos para as Face Shields que foram entregues para os profissionais da saúde no período da pandemia de COVID-19.
Ações de enfermagem ao portador de Esquizofrenia: Evidências científicas atuais
Authors: de Barros Cícera Cristiane , Marinho Júnior Ivan Nunes Marinho , Soares Jandson de Oliveira , Pontes Alessandra Nascimento
Published: January 2023

Introdução: As intervenções de enfermagem discutidas na literatura são: realizar avaliações biopsicossociais levando em consideração as características culturais do paciente; Criação e implementação de planos para melhorar as condições de saúde do paciente e sua família; informar o paciente e sua família sobre as características da doença. O mais importante é evitar se envolver diretamente com o conteúdo psicótico na frente de uma pessoa com sintomas psicóticos. Isso significa que é melhor mostrar vontade de ajudar o paciente na situação que está causando sofrimento do que argumentar que nada do que ele está imaginando é real. Objetivo geral:  é entender quais são as ações que a equipe de enfermagem deve prestar aos portadores dessa doença. Metodologia: trata-se de uma revisão de bibliografias, de forma qualitativa. Resultados: Considerações finais: Diante dessa perspectiva, fica claro o quão importante é o estudo sobre o tema, tendo em vista que ele vem ocupando cada vez mais espaço na sociedade e dessa forma sua discussão permite que a sociedade tenha maior conhecimento sobre. Além disso, é importante destacar os aspectos positivos que fornece a comunidade científica, pois seu estudo permite e abre portas para desenvolvimento de trabalhos futuros.
Cubiu (solanum sessiliflorum): Uma fruta alimentar, medicinal e cultural
Authors: Da Cruz Jozângelo Fernandes , Quiterio Talissa da Conceição , Franco Paola Victoria Moreno , De Castro Albejamere Pereira
Published: January 2023

O cubiu (Solanum sessiliflorum Dunal) é uma espécie nativa da Amazônia, classificada como uma planta alimentícia não convencional (PANC). Trata-se de uma planta arbustiva da família Solanaceae cujos frutos são utilizados como alimento e medicinal pela população da Região. Nas últimas décadas, o cultivo tem sido objeto de diversas investigações e estudos que revelam tanto as suas qualidades físico-químicas como a sua potencialidade agronômica e farmacológica, o que torna o cubiu bastante interessante para a indústria alimentar e farmacêutica. Diante disso, o cultivo representa um recurso promissor para a sociedade da Região Amazônica como alternativa estratégica na agricultura familiar na promoção de uma economia local mais consolidada, promover a sustentabilidade e a segurança alimentar. Nosso objetivo neste trabalho foi realizar uma revisão de literatura a partir de artigos científicos, teses, dissertações e documentos técnicos, destacando a importância socioeconômica e com o objetivo de promover as diferentes utilidades alimentícia e medicinal do fruto do cubiu.
Meningite bacteriana em idosos: Números dos últimos 10 anos no estado de Goiás
Authors: Soares Marília Junqueira Silva , Lucas Junior Carlito José , Assuncao Gilcilene Vieira , Quinan Paulo Victor Monteiro , Vieira Thiago dos Santos
Published: January 2023

A meningite é a inflamação das membranas que recobrem o tecido encefálico, a dura máter, a pia máter e a aracnoide, especificamente a maior parte do cérebro e a medula espinhal. Tal processo geralmente decorre da presença de uma infecção prévia que alcança os tecidos encefálicos, e é mais comum nos extremos de idade, sendo, por motivos imunológicos e estruturais, mais prevalente na faixa pediátrica. Em adultos, acomete principalmente os idosos. Em todo caso, é uma doença com potencial de gravidade, tanto pelas sequelas que podem advir do comprometimento do tecido cerebral subjacente, quanto pela elevada taxa de mortalidade. A morbimortalidade, aliás, é ainda mais importante nos casos em que há o desenvolvimento de complicações locais ou sistêmicas, tais como distúrbios da coagulação, empiema, hipertensão intracraniana, herniação cerebral, convulsões, septicemia e falência orgânica genealizada. Os pacientes que sobrevivem podem ter sua qualidade de vida reduzida por sequelas importantes.A relativa raridade da meningite em adultos, ainda mais com complicações, torna desafiadora uma compreensão científica ampla sobre sua epidemiologia, sua história natural e seu processo fisiopatológico. Tendo tudo isso em vista, o objetivo do presente trabalho é indicar os números da meningite bacteriana em idosos nos últimos 10 anos no estado de Goiás, estabelecendo um comparativo com a literatura mais atual.
Síndrome hemofagocítica: um relato de caso
Authors: Vieira Karoline Araujo , Souza Gustavo Henrique Gandolfo
Published: January 2023

A Síndrome hemofagocitica (SHF) é um quadro caracterizado por uma proliferação maligna de histiocitos com intensa atividade fagocitaria de células saudáveis, ocasionando a ativação sistêmica de macrófagos, levando a um processo inflamatório agudo grave, rapidamente progressivo. É uma condição clínica de difícil diagnóstico e com múltiplas causas: infecções, neoplasias, doenças autoimunes e doenças onco-hematologicas. Objetivos: expor um relato de caso da SHF, atendido em um pronto atendimento de um hospital de grande centro e apresentar uma discussão a cerca dessa doença com base na literatura, considerando sua dificuldade em fazer o diagnóstico e sua gravidade. O maior empecilho para o tratamento bem sucedido é um atraso no diagnóstico e infelizmente esse fator ocorre em vista da raridade da síndrome, da apresentação clínica variável e da falta de especificidade dos achados clínicos e laboratoriais. Logo, a importância de iniciar tratamento quando houver uma suspeita clínica forte de síndrome hemofagocítica. Conclusão: vê-se que a síndrome hemofagocítica é sim um diagnóstico raro, mas que não pode ser descartado quando se apresenta como uma hipótese diagnóstica, já que como discutido é um quadro de gravidade que leva a uma disfunção múltipla dos órgãos de forma súbita.
Gestão estratégica da manutenção de máquinas agrícolas: estudo de caso em uma usina sucroalcooleira no Triângulo Mineiro
Authors: Da Silva Douglas Brito , Garcia Marcos Zanusso Ferreira , Dutra Júlio Afonso Alves
Published: January 2023

O presente artigo discorreu acerca da gestão estratégica da manutenção de máquinas agrícolas, desenvolvendo um estudo de caso em uma Usina localizada na região do Triângulo Mineiro. O problema de pesquisa teve como foco a análise sobre como se dá o funcionamento do processo de manutenção dos equipamentos que englobam o tripé carregamento, corte e transporte (CCT) no setor sucroalcooleiro desta Usina. Vislumbrou-se que na Usina em estudo são desenvolvidas práticas que abordam os processos de gestão da manutenção, objetivando o controle dos processos e a redução dos desperdícios, sejam de tempo ou na questão financeiras, contudo, é necessário ainda o desenvolvimento de melhorias no que tange a questão da gestão de suprimentos e também na capacitação dos colaboradores.
Características geomorfológicas do Egito-praia, lobito, benguela, Angola: potencialidades geodidácticas como polígono de práticas de campo em geografia
Authors: Rodriguez Pedro Acevedo , Agostinho Fernando Vianeque , Tomás Paulo Pedro , Bandeira Manuel Francisco , Gutiérrez Adalberto Giral
Published: January 2023

O artigo teve como objectivo caracterizar as particularidades do relevo da comuna do Egito-Praia, no município do Lobito, Benguela, para a identificação das suas potencialidades geodidácticas para as prática de campo em Geografia. O estudo baseou-se na sistematização dos referenciais teóricos, na análise e interpretação de imagens aéreas a partir do software google-earth e dos mapas topográficos analógicos, seguindo-se o trabalho de campo para a observação, inventariação e caracterização do relevo desta zona, que permitiu elaborar um esquema cartográfico de caracterização do relevo, com o recurso ao software “Adobe Photoshop, versão 8.0.1.”. Os resultados permitiram constatar uma ampla variedade morfológica e morfométrica, com forte dinâmica dos processos formadores (tectónicos, marinhos, fluviais e denudativos), com o sustentável carácter tectónico ascendente que terá causado a contínua regressão marinha, formando diferentes níveis de planícies monoclinais de diferentes idades (Quaternárias), que alcançam os 200m de altitude e teriam sido cortadas por actividade do curso de água local (rio Balombo), conformando um estreito e profundo canyon fluvial. O estudo permitiu ainda determinar a existência de três unidades geomorfológicas gerais: o relevo litoral (marinho), o relevo fluvial, principalmente representado pelo canyon do rio Balombo e o relevo estrutural-denudativo, conformado por diferentes níveis de superfícies elevadas de origem marinha e estrutura monoclinal, convertendo-se em potencialidades geodidácticas como polígono de práticas de campo em Geografia no contexto educativo dos municípios do litoral da província de Benguela, além de potenciar o desenvolvimento local no âmbito do sector turístico.