bluuebunny/crossref_metadata_2025 huggingface dataset:
Apontamentos sobre a imunidade tributária dos livros, jornais e periódicos e do papel destinado à sua impressão
Authors: Cavalli Cássio
Published: February 2016

Este artigo é sobre a imunidade tributária dos livros, jornais e periódicos e do papel destinado à sua impressão. Esta hipótese de imunidade tributária foi instituída pela primeira vez na Constituição brasileira de 1946, em um contexto histórico específico. Esta hipótese de imunidade foi prevista pelos textos constitucionais posteriores, mas em contextos históricos e tecnológicos diferentes. Este artigo busca identificar os argumentos relacionados a esta espécie de imunidade tributária ao longo dos tempos, de modo a contribuir para a sua aplicação no contexto histórico e tecnológico atual.  This article is about the tax immunity of books, newspapers, periodicals and paper for the printing. This hypothesis of tax immunity was first enacted in the Brazilian Constitution of 1946, in a specific historical context. This hypothesis was provided by subsequent constitutional texts, but in different historical and technological contexts.This article seeks to identify the arguments related to this kind of tax immunity over time in order to contribute to its implementation in the current technological and historical context.
O poder de polícia administrativa e a realização dos direitos fundamentais: um estudo a partir de decisões do STF
Authors: Souza Leonardo da Rocha de
Published: February 2016

O poder de polícia administrativa está intimamente ligado à realização dos direitos fundamentais, já que pressupõe a limitação de alguns direitos para a realização de outros. O art. 78 do Código Tributário Nacional indica alguns direitos que devem ser protegidos pelo Estado e apresenta requisitos para essa proteção. O presente trabalho analisa os elementos do referido art. 78 à luz de decisões do Supremo Tribunal Federal, buscando-se, nos casos práticos, destacar lições para sua aplicação.  The administrative police power is closely linked to the achievement of fundamental rights, since it presupposes the restriction of some rights for the realization of others. In the article 78, of National Tax Code, there are some rights should be protected by the State and some requirements for such protection. This paper examines the elements of that article 78 in the light of decisions by the Brazilian Supreme Court, seeking, in practical cases, to highlight lessons for their application.
O Estado responsável e a maioridade democrática - breves considerações ao projeto de lei sobre responsabilidade civil do Estado
Authors: Wada Ricardo Morishita
Published: February 2016

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Agentes políticos eletivos e Direitos Sociais
Authors: Almeida Renato Franco de
Published: February 2016

Propõe-se averiguar a possibilidade de agentes políticos eletivos auferirem direitos sociais inerentes a trabalhadores, à luz do seu caráter histórico e das cláusulas constitucionais de regência. Busca-se, também, através de exame analítico dos dispositivos constitucionais, propor a incompatibilidade de leis que concedem tais direitos sociais àqueles agentes políticos.  One considers to inquire the possibility of agents elective politicians to gain inherent social rights the workers, to the light of its historical character and the constitutional clauses of regency. One searchs, also, through analytical examination of the constitutional devices, to propose the incompatibility of laws that grant to such social rights to those agents politicians.
Tabelamento de preços mínimos pelo sindicato das autoescolas
Authors: Mattos César Costa Alves de
Published: February 2016

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A constituição do experimentalismo democrático
Authors: Unger Roberto Mangabeira
Published: February 2016

Este artigo, transcrição de uma palestra, analisa e critica a tradição constitucional brasileira como resultado de duas tradições maiores: o constitucionalismo protodemocrátcio dos Estados Unidos e o weimarismo tardio, característico das constituições europeias do século XX, com sua dedicação a direitos econômicos e sociais, desfalcados de instrumentos de efetivação, e com sua ambivalência em relação ao poder político. Argumenta que as ideias institucionais destas tradições não servem para aprofundar a democracia nas sociedades contemporâneas. Denuncia a falta de realismo e de imaginação em nossa doutrinação constitucional, quase toda ela dedicada à imitação e à mistura das constituições adotadas nos países do Atlântico Norte. Propõe outro rumo. Exemplifica a prática do pensamento jurídico como exercício da imaginação institucional.   This article, the transcript of a lecture, analyzes and criticizes the Brazilian constitutional traditional as the outcome of two major traditions: the proto- democratic constitutionalism of the United States and the constitutionalism of Europe in the twentieth century (“belated Weimarism”), with its confused devotion to social and economic rights, unsupported by institutions capable of implementing them, and with its ambivalence to political power. It argues that the institutional ideas of these traditions do not help deepen democracy in contemporary societies. It denounces the lack of realism and of imagination in Brazilian constitutional thinking, almost invariably attached to the imitation and to the blending of the constitutions adopted in North-Atlantic countries. It proposes another way. It exemplifies the practice of legal thought as an exercise of institutional imagination.
Administração pública deve aplicar a lei fundamental de ofício e deixar de aplicar regras inconstitucionais, quando cumpri-las significar improbabilidade por quebra de princípios
Authors: Freitas Juarez
Published: February 2016

A administração pública tem o dever ex officio de proteger os direitos constitucionais e a moralidade. Tais deveres presumem amplificação do autocontrole, respeito às decisões judiciais consolidadas e favorecem a assertiva do princípio da deferência. A tarefa de evitar a “deflação” constitucional é para todos os agentes do Estado, de acordo com suas atribuições, e representa o aspecto crucial do novo direito administrativo. Em outras palavras, a constitucionalidade dos atos administrativos — além do cumprimento das regras jurídicas — precisa ser assegurada e garantida pelo Estado, incluindo a administração pública. O controle, em última instância, permanece do Judiciário. Isto é, o controle de constitucionalidade não se torna fraco, mas articula, de forma integrada, o controle sistemático que não permite a inatividade ou a omissão violadora da Constituição e, ao mesmo tempo, direciona as melhores energias em direção às prioridades fundamentais da república.   The public administration has the ex officio duty of protecting constitutional rights and morality. Such duty presumes amplification of selfcontrol, respect of consolidated judicial decisions and favors the assertion of the deference principle. The task of avoiding the constitutional “deflation” is for all State agents and, according to their attributions, represents a crucial aspect of the new administrative law. In other words, the constitutionality of administrative acts — besides their compliance with legal rules — needs to be insured and guaranteed by the whole State, including public administration. The “ultimate control” remains with the Judiciary, that is, the judicial review does not get weak, but articulates, in an integrated way, the systematic control that doesn’t allow the inactivity or violatory omission of the Constitution and, at the same time, directs the best energies towards the fundamental republican priorities.
A liberdade de contratar para a administração pública: a autonomia da vontade no contrato administrativo
Authors: Sousa Guilherme Carvalho e
Published: February 2016

A autonomia da vontade pode ser considerada um dos elementos do contrato, mas, nem sempre, foi vista como condição necessária para sua existência e nem seu elemento central. O contrato administrativo, precedido de um procedimento prévio de escolha do contratante particular, possui características próprias que o diferencia dos demais contratos típicos de direito privado. A liberdade de contratar para a administração pública não é plena, e existe nos limites da motivação do ato, declarando a finalidade última do Estado: o interesse público previsto em lei. A supremacia do interesse público e a busca da vontade coletiva mitigam a autonomia da vontade para a administração, evitando o arbítrio.   The autonomy of the will can be considered as an element of the contract, but not always, been seen as a necessary condition for their existence and not its central element. The administrative contract, preceded by a previous procedure of choosing a particular contractor, has its own characteristics that differentiate them from other contracts typical of Private Law. The freedom to contract for Public Administration is not full, and there on the edge of the motivation of the act, declaring that the ultimate purpose of the state: the public interest provided by law. The supremacy of public interest and the pursuit of collective will mitigate the freedom of choice for the Administration, avoiding arbitration.
Licitações públicas sustentáveis
Authors: Garcia Flávio Amaral , Ribeiro Leonardo Coelho
Published: February 2016

Este artigo assume que as licitações e contratações públicas vêm sendo, assim como outros institutos do direito administrativo, revisitadas com base em novos paradigmas, com especial destaque para a sustentabilidade. A intenção deste estudo é a de investigar as principais questões que circundam o instituto das licitações públicas sustentáveis, visando analisar a sustentabilidade como valor global que demanda a elaboração de políticas públicas no Brasil.   This article assumes that the public bidding processes, as well as other administrative law institutes, have been revisited based on new paradigms with a special focus on sustainability. This study’s intention is to investigate the main issues concerned to the sustainable public bidding processes in order to analyze the sustainability as a global value that demands the creation of public policies in Brazil.
O Supremo Tribunal Federal - uma breve análise da sua criação
Authors: Direito Gustavo
Published: February 2016

O presente trabalho tem como objetivo fazer uma análise do surgimento do Supremo Tribunal Federal (STF) quando do nascimento da República brasileira. Aprecia-se, então, a transição dentro do Poder Judiciário no momento em que passamos do Império à República. Nesse sentido, busca-se demonstrar como o STF tem sua atuação ampliada na nova ordem política do Brasil. Com efeito, o órgão máximo da justiça pátria passa a ocupar a posição de destaque na sociedade. Vive, então, a nova Corte Constitucional um aparente dilema: ou se protegem os direitos individuais ou se assegura a manutenção da unidade nacional. A apreciação deste particular momento histórico da justiça brasileira é o que se pretende neste texto.   The present work aims to present an analysis of the Supreme Court’s (STF) creation on the Brazilian Republic birth. Thus, it is carried through an analysis over the Judiciary within the transition from the Empire to the Republic. The intention is to discuss how the Supreme Court has expanded its strategies in the new Brazilian political order. Indeed, this highest legal institution occupies a prominent position in society. Although, it faces a new apparent dilemma: or it protects the individual rights or it ensures the maintenance of national unity. The discussion of this particular historical moment of Brazilian justice is what is intended in this text.
Termo de compromisso de pagamento de honorários médicos: o caso da Unimed
Authors: Ragazzo Conselheiro Carlos Emmanuel Joppert
Published: February 2016

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Serviço voluntário nas unidades judiciárias como prática jurídica para estudantes de direito
Authors: Cavalcanti Conselheiro Felipe Locke
Published: February 2016

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Direito e Consequência no Brasil: em busca de um discurso sobre o método
Authors: Pargendler Mariana , Salama Bruno Meyerhof
Published: February 2016

Proliferam hoje instituições de pesquisa e trabalhos acadêmicos em direito que — diferentemente do método jurídico tradicional, mas à semelhança das demais ciências sociais — objetivam investigar os efeitos das normas jurídicas sobre a realidade econômica e social. No presente artigo sustentamos que, no Brasil, a adoção de novas metodologias na produção jurídica liga-se à transformação no modo de aplicação do direito, que vem crescentemente consagrando a utilização de argumentos consequencialistas em juízo. Examinamos, então, os três vetores de caráter ideológico (o triunfo do progressismo), organizacional (a centralidade do Poder Judiciário no arranjo político) e técnico-jurídico (o reconhecimento da força normativa dos princípios) que forjaram tal transformação no contexto brasileiro. Daí decorre que a aplicação do direito cada vez mais exija não apenas a averiguação de fatos pretéritos para determinar a incidência do suporte fático de regras, mas também juízos probabilísticos sobre fatos futuros a fim de concretizar os fins jurídicos consubstanciados em princípios — propiciando, assim, o surgimento de um potencial novo campo de pesquisa para os juristas. Todavia, a persistência de uma incerteza radical sobre o funcionamento do mundo — inclusive sobre as consequências de diferentes normas jurídicas — inviabiliza o consequencialismo extremado como técnica de decisão sobre a organização social. Em razão da inabilidade das ciências sociais em ditar o funcionamento do sistema jurídico, subsistirá o papel do jurista como formulador de doutrina como não ciência.   Today, a growing number of research institutions and academic works in law seek to investigate the effects of legal rules on social and economic reality, a goal that differs from that of traditional doctrinal scholarship but is similar to the aspirations of other social scientists. In this Article, we argue that, in Brazil, the adoption of new methodologies in legal scholarship relates to a transformation in the mode of legal interpretation towards greater acceptance of the use of consequentialist arguments in court. As a result, judicial interpretation increasingly requires not only the verification of past facts that are abstractly described in legal rules, but also probabilistic judgments about future facts in order to carry out the legal objectives embodied in legal principles. Nevertheless, the persistence of radical uncertainty about the workings of the world — including the factual consequences of legal rules — thwarts the use of extreme consequentialist reasoning as a decision method for social organization. In view of social sciences’ inability to dictate how the legal system is to operate, the role of legal scholars as authors of doctrine as non-science will subsist.
I Relatório do Supremo em Números - O múltiplo Supremo
Authors: Falcão Joaquim , Cerdeira Pablo , Arguelhes Diego
Published: February 2016

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A Judicialização da Política: teorias, condições e o caso brasileiro
Authors: Brandão Rodrigo
Published: February 2016

Este artigo se destina a analisar as teorias e condições para a judicialização da política, com a finalidade de se compreender adequadamente a expansão do Supremo Tribunal Federal (STF).   This paper aims to analyze the theories and conditions of the judicialization of politics, in order to understand the expansion of the Brazilian Supreme Court.
Centrais Sindicais: histórico e constitucionalidade
Authors: Jobim Nelson A. , Kaufmann Rodrigo de Oliveira
Published: February 2016

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Cartéis de Revenda de Combustíveis
Authors: Frazão Conselheira Ana
Published: February 2016

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Uma nova democracia representativa? Internet, representação política e um mundo em transformação
Authors: Oliveira Fábio Cesar dos Santos
Published: February 2016

O estudo analisa a correlação entre a internet e a democracia, pela possível superação de obstáculos que impediriam uma permanente consulta da vontade dos cidadãos. A partir da revisão da bibliografia relacionada ao tema e de pesquisas empíricas já realizadas, verifica-se que os usuários da internet, ressalvada a participação dos mais jovens, integram os grupos com maior facilidade de articulação de seus objetivos junto às instituições políticas. A internet permite, então, uma maior eficácia dos meios para promoção da responsividade dos eleitos, mas não elimina a capacidade de alguns eleitores terem maior poder de influência entre os tomadores de decisões políticas e a importância da representação para a democracia.   This study examines the correlation between the internet and direct democracy, through the possible overcoming of obstacles which would prevent a permanent query of the citizens’ will. Based on the review of the literature related to the theme and on empirical research already carried out, it is possible to assert that the internet users, except for the participation of younger electors, belong to groups which can expose their interests with greater easiness amid political institutions. Therefore, the internet allows more effective means to promote political responsiveness, however it does not eliminate the ability of some electors to have a greater power of influence among decision makers and the importance of representation for democracy.
A política da radiodifusão no Brasil e seu marco legal: do autoritarismo ao ultraliberalismo
Authors: Carvalho Lucas Borges de
Published: February 2016

O artigo apresenta uma análise histórica sobre a política da radiodifusão no Brasil, entendendo-se como tal as metas e prioridades a que se submete o serviço e que se refletem em sua estrutura jurídica. Argumento que, no período compreendido entre a década de 1930 e o fim da ditadura militar, prevaleceu um modelo autoritário, no qual a forte intervenção estatal convive com a exploração econômica do serviço por particulares. Esse modelo será modificado pela Constituição de 1988, que institui as bases de uma política democrática para a radiodifusão. A implementação dessa política, no entanto, foi bloqueada por diversos fatores, levando a um modelo ultraliberal, caracterizado por uma esfera de imunidade das emissoras diante de controles democráticos e da ação reguladora estatal.   The article presents a historical analysis of the broadcasting policy in Brazil, understanding as such goals and priorities to which the service is subjected and which are reflected in its legal form. I argue that, in the period between the 1930s and the end of military dictatorship, an authoritarian model has prevailed, in which strong state intervention coexists with private economic exploitation of the service. This model will be modified by the 1988 Constitution, which introduced the foundations of a democratic policy for broadcasting. The implementation of this policy, however, was locked by several factors, leading to an ultraliberal model characterized by a sphere of immunity of broadcasters against democratic controls and the State regulatory action.
Desastres naturais e as contratações emergenciais
Authors: Moreira Neto Diogo de Figueiredo , Garcia Flavio Amaral
Published: February 2016

Este artigo busca analisar os desafios das contratações emergenciais no Brasil em situações de desastres naturais. Tomando como referência a legislação brasileira sobre contratações públicas, busca apresentar as formalidades exigidas e os caminhos jurídicos deste tipo de contratação.   This paper analyzes the challenges of emergency hires in Brazil in situations of natural disasters. Referring to Brazilian legislation on public contracts, it seeks to present the required formalities and the legal ways of this type of contract.
O mundo real da análise de custo-benefício: 36 questões (e quase tantas respostas quanto)
Authors: Sunstein Cass R.
Published: February 2016

Algumas das discussões mais interessantes sobre a análise de custo-benefício focam problemas difíceis, incluindo cenários catastróficos, “fat tails”, incerteza extrema, equidade interagências e descontos sobre horizontes longos de tempo. Como opera no mundo real da prática governamental, entretanto, a análise de custo-benefício normalmente não precisa explorar as questões difíceis, e, quando isso acontece, tende a conseguir métodos e ferramentas padronizados. É muito útil abordar a análise de custo benefício de baixo para cima, ou seja, fixando a discussão em cenários específicos envolvendo compensações e avaliações. Trinta e seis cenários são apresentados aqui, juntamente com uma exploração de como eles devem ser controlados na prática. As questões abertas são também discutidas.   Some of the most interesting discussions of cost-benefit analysis focus on difficult problems, including catastrophic scenarios, “fat tails,” extreme uncertainty, intergenerational equity, and discounting over long time horizons. As it operates in the actual world of government practice, however, cost-benefit analysis usually does not need to explore the hardest questions, and when it does so, it tends to enlist standardized methods and tools. It is useful to approach cost-benefit analysis from the bottom up, that is, by anchoring the discussion in specific scenarios involving trade-offs and valuations. Thirty-six stylized scenarios are presented here, alongside an exploration of how they might be handled in practice. Open issues are also discussed.
Publicidade, transparência e abertura na administração pública
Authors: Rodrigues João Gaspar
Published: February 2016

Este trabalho ocupa-se do princípio republicano da publicidade e de seus corolários constitucionais dentro da atividade administrativa, à luz da recente Lei de Acesso à Informação e das diretrizes constitucionais. Para o funcionamento fluido de uma sociedade aberta, todo escaninho estatal está sujeito às luzes da publicidade. O conceito de que a transparência na administração pública é essencial para que possa funcionar de forma mais responsável e eficaz está ganhando importância crescente na teoria do direito administrativo.   This paper deals with the republican principle of advertising and its corollaries within the constitutional administrative activity, in light of the recent Access to Information Act and the constitutional guidelines. For the smooth functioning of an open society throughout bin state is subject to the lights of publicity. The concept of transparency in the public administration is essential for it to function more responsibly and effectively is gaining increasing importance in the theory of administrative law.
Depósitos judiciais no Paraná
Authors: Bahia Conselheiro Saulo Casali
Published: February 2016

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Analysis of Labour Efficiency and Human Capital Assessment in the Russian Federation on the Example of Siberian Federal District
Authors: Комарова  , Komarova Anna , Басовский  , Basovskiy Leonid
Published: February 2016

With the use of regression analysis, we calculated the elasticity of labor efficiency

by education level of the employed population. The analysis included regional

data from the Federal State Statistics Service of Russia.

The implemented methodology is based on econometric models of labour

productivity in the regions of the Siberian Federal District of Russia. It is shown

that the level of education of the working population is a significant factor

in determining the productivity of labour in the regions of the Siberian Federal

District of Russia.
Analysis of definition and principles of composite materials development
Authors: Кочешков И , Kocheshkov I
Published: February 2016

Despite of the great success in composite material science, there is still no definitionto the composite materials, which could show their essence and difference from all other materials. The purpose of this research is to clarify “composite material” definition and principles of their formation, which allow to obtain the required properties.
Screening of elite black soybean lines for resistance to rust disease, Phakopsora pachyrhizi
Authors: KRISNAWATI AYDA , S. GATUT WAHYU A. , ADE M. MUCHLISH
Published: February 2016

risnawati A, Gatut-Wahyu AS, Adie MM. 2016. Screening of elite black soybean lines for resistance to rust disease,Â Phakopsora pachyrhizi. Biodiversitas 17: 134-139. Indonesian tropical climate is ideal for both of soybean growth and harmful diseaseÂ development. Soybean rust, Phakopsora pachyrhizi, has been a serious disease in Indonesia and may have an impact on soybeanÂ production. The objective of the study was to evaluate the resistance of elite black soybean lines to rust disease. Agronomic characters (yield and yield component) were evaluated based on research conducted in 16 soybean production centers in Indonesia. The evaluation for rust resistance was conducted in Indonesian Legumes and Tuber Crops Research Institutes' greenhouse in 2011 using ten elite black soybean lines. The seed yield of ten black soybean lines grown in 16 locations ranged from 2.51-2.88 t/ha, with an average of 2.59 t/ha. The eight lines showed higher yield than check cultivar of Malika, whereas only one line (W9837 Ã— Cikuray-66) had higher yield thanÂ check cultivar of Detam-1. Resistance reaction to rust disease fluctuates over time. Two elite lines of Cikuray Ã— W9837-171 and Cikuray Ã— W9837-184 showed a consistent resistance to P. pachyrhizi. W9837 Ã— Cikuray-66 and check cultivar of Detam-1 consistently showed a moderately resistant. In the terms of agronomic aspects, W9837 Ã— Cikuray-66, which has moderately resistant to P. pachyrhizi, produced the highest yield (2.88 t/ha). The both of resistant lines of Cikuray Ã— W9837-171 and Cikuray Ã— W9837-184 haveÂ early maturity, and medium seed size with yield 2.57 t/ha and 2.56 t/ha, respectively. The resistant and moderate lines with high yield, early maturing, and medium seed size found in this study playing an important role in the soybean varietal development program for rust resistance in Indonesia.
Short Communication: Antibacterial activity of Boesenbergia pandurata, Zingiber zerumbet and Solanum ferox extracts against Aeromonas hydrophila and Pseudomonas sp.
Authors: HARDI ESTI HANDAYANI , KUSUMA IRAWAN WIJAYA , SUWINARTI WIWIN , AGUSTINA AGUSTINA , NUGROHO RUDI AGUNG
Published: February 2016

Abstract. Hardi EH, Kusuma IW, Suwinarti W, Agustina, Nugroho RA. 2016. Antibacterial activity of Boesenbergia pandurata, Zingiber zerumbet and Solanum ferox extracts against Aeromonas hydrophila and Pseudomonas sp. Nusantara Bioscience 8:  18-21. This study evaluated the potential antibacterial activity of Boesenbergia pandurata, Zingiber zerumbet and Solanum ferox extracts against Aeromonas hydrophila and Pseudomonas sp. This paper aims to review the best concentration of the extract B. pandurata, Z. zerumbet and S. ferox to inhibit the growth of bacteria A. hydrophila and Pseudomonas sp. on tilapia in vitro test. The concentrations used range from 100-6000 ppm for B. pandurata and S. ferox, meanwhile for Z. zerumbet extracts ranged from 25-1000 ppm. The best concentration was injected to tilapia by intraperitoneal (0.1 mL/fish) to know in vivo inhibition of extract in fish. The results showed that B. pandurata 600 and 900 ppm, and Z. zerumbet 200 and 2000 ppm revealed potent antibacterial activity against A. hydrophila; while the concentration of S. ferox at 400 and 900 ppm inhibits Pseudomonas sp. growth, whereas concentration of 600, 200, and 900 ppm reduced the bacterial pathogen in fish body.
«Lenticchie e salumi»: l’ekphrasis negli storici greci
Authors: De Martino Francesco
Published: February 2016

Come mostrano numerose testimonianze, la storiografia è il genere più congeniale —persino più dell’epica— alle descrizioni. Il monito di moderare l’uso dell’ekphrasisprende di mira gli eccessi di alcuni storici, tipo quelli ridicolizzati da Luciano inCome si scrive la storia.
Dos nuevas estelas funeraria en Fresno de Río Tirón (Burgos)
Authors: Fernández Corral Marta , Carcedo de Andrés Bruno P.
Published: February 2016

El objetivo de este trabajo es dar a conocer dos nuevas estelas funerarias de época romana localizadas en el verano de 2014 y primavera de 2015 en Fresno de Río Tirón (Burgos). Las características de las estelas nos hacen pensar que son dos ejemplos más del llamado conjunto epigráfico de Belorado (Burgos) bien reconocibles debido a su soporte y características internas.
Pleomorphic adenoma of the upper lip: a case report and review of literature
Authors: Metgud Rashmi , Neelesh Bhardwaj Tina , Goel Saurabh , Nail Smitha , Patel Shrikant , Tak Anirrudh
Published: February 2016

Pleomorphic Adenoma is a benign epithelial tumor arising from the salivary gland. It is a benign mixed tumor composed of epithelial and myoepithelial cells arranged with various morphological patterns, demarcated from surrounding tissues by fibrous capsule. In this article, we report an unusual case of 30 year, male with a single, nodular swelling evident in the upper lip which was discovered during a routine dental procedure. Fine Needle Aspiration Cytology (FNAC) was planned for the patient, where a of cytological diagnosis of Pleomorphic Adenoma was rendered, which was confirmed by biopsy. Hence, this highlights, FNAC makes up an important diagnosing tool as the first line of investigation to distinguish between benign and malignant salivary gland neoplasms.
Ethanol production from olive stone hydrolysates by xylose fermenting microorganisms
Authors: Romero-García J.M. , Martínez-Patiño C. , Ruiz E. , Romero I. , Castro E.
Published: February 2016

Olive stones are the main solid byproducts obtained from olive oil production and from table olives production. As a lignocellulosic material, the use of olive stones for ethanol and other chemicals production has been proposed, particularly under the biorefinery concept. As part of such a process, this work deals with the fractionation of the lignocellulosic material by dilute acid autoclave pretreatment at 2% sulfuric acid, 130°C, 60 min and 1:1 liquid to solid ratio. Moreover, the work addresses the fermentation of the liquors obtained after pretreatment. The released sugars are composed mainly by xylose and other hemicellulosic sugars. The fermentation performance of three xylose-fermenting microorganisms, e.g. two Escherichia coli species and Scheffersomyces stipitis, are compared. The study analyzes in a first step the microorganism behavior on synthetic liquors, with a similar composition to that of the real liquors. Finally, and taken into account the results from the previous steps, the real liquor obtained from olive stones pretreatment is fermented. Results show that E. coli MM160 is the best ethanol producer out of the three microorganisms studied. Globally, the pretreatment produced a liquor containing 140 g hemicellulosic sugars/l and requiring firstly dilution by 50% and a detoxification step by overliming. The fermentation of this liquor by E. coli MM160 results in a 25 g ethanol/l solution equivalent to 50 g ethanol/kg olive stone, in spite of 20 g acetic acid/l also present. These results confirm both olive stones and E. coli MM160 as promising feedstock and microorganism for ethanol production.
Alkaline pretreatment for practicable production of ethanol and xylooligosaccharides
Authors: Nascimento Viviane Marcos , Manrich Anny , Tardioli Paulo Waldir , de Campos Giordano Roberto , de Moraes Rocha George Jackson , Giordano Raquel de Lima Camargo
Published: February 2016

The economics for production of secondgeneration (2G) ethanol from sugarcane bagasse in large scale, competing with the cogeneration of electric energy, is still not consolidated. In this scenario, the key for feasibility may be the biorefinery concept, a multiproduct industry using biomass fractions to produce energy, chemicals and by-products. Xylooligosaccharides (XOS) are oligomers of xylose often used as additives in food, animal feeds, and drugs. The effect of NaOH pretreatment on the recovery of xylan for XOS production from sugarcane bagasse under different conditions, namely 121°C, 4-7% NaOH loading, was investigated. The best condition was 4% NaOH and 60 min of reaction, achieving 55% of xylan extraction, without monomer production. In order to produce XOS, soluble and immobilized xylanases were used to hydrolyze commercial birchwood xylan (as control) and the sugarcane bagasse xylan. The immobilized endoxylanase produced XOS with 37% of xylobiose and 20% of xylotriose (w/w). The small production of xylose clearly indicated the purity of the xylan extracted from sugarcane bagasse. The biocatalyst had more than 90% of its activity preserved after 5 reaction cycles. The results showed the suitability of sugarcane bagasse as a raw material for production of ethanol and of XOS using immobilized xylanase.
Investigating the impact of missense mutations in hCES1 by in silico structure-based approaches
Authors: Nzabonimpa Grace Shema , Rasmussen Henrik Berg , Brunak Søren , Taboureau Olivier , for the INDICES Consortium
Published: February 2016

Genetic variations in drug-metabolizing enzymes have been reported to influence pharmacokinetics, drug dosage and other aspects that affect therapeutic outcomes. Most particularly, non-synonymous single-nucleotide polymorphisms (nsSNPs) resulting in amino acid changes disrupt potential functional sites responsible for protein activity, structure, or stability, which can account for individual susceptibility to disease and drug response. Investigating the impact of nsSNPs at a protein’s structural level is a key step in understanding the relationship between genetic variants and the resulting phenotypic changes. For this purpose, in silico structure-based approaches have proven their relevance in providing an atomic-level description of the underlying mechanisms. The present review focuses on nsSNPs in human carboxylesterase 1 (hCES1), an enzyme involved in drug metabolism. We highlight how prioritization of functional nsSNPs through computational prediction techniques in combination with structure-based approaches, namely molecular docking and molecular dynamics simulations, is a powerful tool in providing insight into the underlying molecular mechanisms of nsSNPs phenotypic effects at microscopic level. Examples of in silico studies of carboxylesterases (CESs) are discussed, ranging from exploring the effect of mutations on enzyme activity to predicting the metabolism of new hCES1 substrates as well as to guiding rational design of CES-selective inhibitors.
Compact Diplexer with High Isolation based on Novel Symmetric Double Spiral Resonators
Authors: Le Ru , Wensheng Chi , Yaqing Liu , Haidong Yang
Published: February 2016

In this paper, the electromagnetic characteristics of the reported miniaturized bandpass filter (BPF) in reference are investigated deeply, and then a planar compact diplexer centred at 1.86/2.16 GHz is designed by using a T-junction to connect the reported BPFs. For verification, the designed diplexer are fabricated and measured. The measured and simulated results of the diplexer are in good agreement with each other, showing that the measured 3-dB bandwidth for the two passbands are 6.45 % (1.79–1.91 GHz) at 1.86 GHz and 6.94 % (2.08–2.23 GHz) at 2.16 GHz with return losses better than 20 dB. Moreover, the insertion losses of the two passbands are less than 0.7 and 0.9 dB, and the isolations are higher than 48 and 36 dB, respectively. Besides, compared with the diplexers reported in recent references, this one has more superior performances.
Congenital hypothyroidism and thyroid dyshormonogenesis: a case report of siblings with a newly identified mutation in thyroperoxidase
Authors: Sparling David P. , Fabian Kendra , Harik Lara , Jobanputra Vaidehi , Anyane-Yeboa Kwame , Oberfield Sharon E. , Fennoy Ilene
Published: February 2016

Thyroid dyshormonogenesis continues to be a significant cause of congenital hypothyroidism. Over time, forms of thyroid dyshormonogenesis can result in goiter, which can lead to difficult management decisions as the pathologic changes can both mimic or lead to thyroid cancer.

Herein we describe the cases of two brothers diagnosed with congenital hypothyroidism, with initial findings consistent with thyroid dyshormonogenesis. One brother eventually developed multinodular goiter with complex pathology on biopsy, resulting in thyroidectomy.

Whole exome sequencing revealed the brothers carry a novel frameshift mutation in thyroperoxidase; the mutation, while not previously described, was likely both deleterious and pathogenic.

These cases highlight the complex pathology that can occur within thyroid dyshormonogenesis, with similar appearance to possible thyroid cancer, leading to complex management decisions. They also highlight the role that a genetic diagnosis can play in interpreting the impact of dyshormonogenesis on nodular thyroid development, and the need for long-term follow-up in these patients.
Effects of slip on oscillating fractionalized Maxwell fluid
Authors: Jamil Muhammad
Published: February 2016

The flow of an incompressible fractionalized Maxwell fluid induced by an oscillating plate has been studied, where the no-slip assumption between the wall and the fluid is no longer valid. The solutions obtained for the velocity field and the associated shear stress, written in terms of H-functions, using discrete Laplace transform, satisfy all imposed initial and boundary conditions. The no-slip contributions, that appeared in the general solutions, as expected, tend to zero when slip parameter
Fabrication of Hydrophobic Surface on Wood Veneer via Electroless Nickel Plating Combined with Chemical Corrosion
Authors: Tang Zhaojun , Shi Changhong , Wu Shu , Jiang Zengfu , Wang Lijuan
Published: February 2016

Birch veneers were coated with Ni-P films by a combined process of KBH4 activation and electroless plating. The plated veneers were further chemically corroded to obtain hydrophobic surfaces on wood. The effect of chemical corrosion on the contact angle of the veneers was investigated. The hydrophobic veneers were characterized by X-ray photo electron spectroscopy (XPS), scanning electron microscopy (SEM), and X-ray diffraction (XRD). The surface contact angle of birch veneer before and after it was plated with Ni-P alloy coating was 41º and 121º, respectively. The contact angle reached 136.7º when the nickel-coated veneers were corroded in CuSO4 aqueous solution for 30 min. XPS analysis showed that Cu0 cluster doped with little CuO formed on the corroded surface of Ni-P alloy film after chemical corrosion. SEM and XRD showed that rough copper clusters formed on the surface of the wood veneer and revealed the reason of the surface hydrophobicity. This study provides a new pathway for fabricating hydrophobic wood.
Antibacterial Modification of Microcrystalline Cellulose by Grafting Copolymerization
Authors: Liu Ying , Li Lin , Li Xiaolin , Wang Yingfeng , Ren Xuehong , Liang Jie
Published: February 2016

Microcrystalline cellulose (MCC) has the advantage of a high specific surface area as compared to that of conventional cellulose fibers. In this study the monomer methacrylamide (MAM) was used to treat MCC by grafting copolymerization. SEM, FTIR, and solid 13C NMR were used to characterize the morphology and composition of MAM-g-MCC. After the chlorination of MAM-g-MCC with 10% sodium hypochlorite solution, the grafted MCC exhibited antibacterial activity as a result of the formation of N-Cl bonds. The thermal stability, antibacterial ability, and storage stability of chlorinated MAM-g-MCC were also studied. The results showed that the chlorinated MAM-g-MCC had excellent storage stability and could inactivate all S. aureus and E. coli O157:H7 within 10 min.
Análisis de la posición de la amígdala cerebelosa, con resonancia nuclear magnética, antes y después de la corrección instrumentada por vía posterior en pacientes con escoliosis idiopática del adolescente. [Magnetic Resonance Imaging Evaluation of the Position of the Cerebellar Tonsil before and after Posterior Spinal Fusion in Adolescent Idiopathic Scoliosis.]
Authors: Bosio Santiago Tomas , Puigdevall Miguel , Hokama Jorge , Maenza Ruben
Published: February 2016

Introducción: El objetivo de este estudio fue analizar las variaciones de posición de la Amígdala Cerebelosa, con resonancia nuclear magnética, antes y después de la corrección de la deformidad espinal mediante una artrodesis vertebral posterior instrumentada (AVP) en pacientes con escoliosis idiopática del adolescente (EIA) que no presentaban sintomatología neurológica.

Materiales y métodos: Se evaluaron retrospectivamente 40 pacientes con EIA que no presentaban síntomas neurológicos y a los cuales se les realizó una AVP instrumentada para corregir la deformidad espinal.  Se realizó RNM de la fosa cerebral posterior y de la columna cervical en todos los pacientes antes y después de la cirugía espinal. El nivel de la amígdala cerebelosa con respecto al foramen magnum se midió con el método descripto por Aboulezz et al 3.

Resultados: La magnitud pre-operatoria promedio de la curva escoliótica fue de 53,15° (DS 10,46°) y de la cifosis torácica fue de 35,42º (DS 12,38°). En el post-operatorio inmediato la magnitud promedio fue de 7,45º (DS 7,33°) y de 27,87º (DS 9,03°), respectivamente. La corrección promedio lograda con la AVP fue de 86% en el plano coronal  (p<0.00001). El valor promedio de la longitud de la columna en el plano coronal fue de 44,5 cm (SD 5,25 cm) en el pre-operatorio y de 48,27 cm (DS 4,40 cm) en el post-operatorio (p<0.00001). El valor promedio de la longitud de la columna vertebral en el plano sagital fue de 50,87 cm (DS 4,47 cm) en el pre-operatorio y de 55,13 cm (DS 3,27 cm) en el post-operatorio (p<0.00001). No se observó una diferencia significativa respecto de la posición de la amígdala cerebelosa en las mediciones realizadas antes y después de corregida la deformidad espinal. (p=0,6042). En 10 de los 40 pacientes, se observó un desplazamiento caudal de la amígdala cerebelosa luego de realizada la AVP. En 21 pacientes no se observó ninguna variación en la posición de la amígdala cerebelosa, y en 2 se observó un desplazamiento cefálico de la misma.

Conclusión: No observamos una variación significativa de la ubicación de la amígdala cerebelosa respecto del agujero occipital en pacientes con EIA que fueron sometidos una AVP instrumentada para corregir la deformidad espinal. No se encontró correlación entre la magnitud d
Técnica de Bristow-Latarjet en la inestabilidad glenohumeral anterior. [Bristow-Latarjet Technique in the Treatment of Anterior Shoulder Instability.]
Authors: Jiménez Isidro , Marcos-García Alberto , Medina José , Caballero Jonathan , Muratore Moreno Gustavo
Published: February 2016

Objetivo: Analizar los resultados obtenidos a medio plazo en los pacientes que hemos intervenido mediante la técnica de Bristow-Latarjet teniendo en cuenta el valor del ISIS preoperatorio.

Material y métodos: Estudio retrospectivo de 33 pacientes intervenidos entre 2005 y 2012 con edad media de 33 (21-68) años y seguimiento medio de 6 (2-9) años. Se recogió el resultado con las escalas de Rowe y Constant, cuestionario DASH y una encuesta de valoración subjetiva del resultado por parte de cada paciente.

Resultados: No hubo recidivas. La puntuación media postoperatoria en la escala de Rowe fue de 74.6 (15-100) puntos y de 70 (32-98)  puntos en la escala de Constant. En el cuestionario DASH el valor promedio fue 22.9 (0-73) puntos. El 79% de los pacientes se mostraron satisfechos con el resultado. Se produjo la migración del tornillo en un paciente encontrándose asintomático. No se identificaron otras complicaciones.

Conclusiones: Consideramos, como está reflejado en la literatura, que la técnica de Bristow–Latarjet en el tratamiento de la inestabilidad glenohumeral anterior es una técnica fiable y con una baja tasa de recidivas por lo que debe emplearse como cirugía de elección en determinados casos y, para ello, creemos que la valoración preoperatoria con la escala ISIS es una buena guía a la hora de indicar el tipo de cirugía.
Placental Complications and Bronchopulmonary Dysplasia: EPIPAGE-2 Cohort Study
Authors: Torchin Héloïse , Ancel Pierre-Yves , Goffinet François , Hascoët Jean-Michel , Truffert Patrick , Tran Diep , Lebeaux Cécile , Jarreau Pierre-Henri
Published: February 2016

OBJECTIVE:

To investigate the relationship between placenta-mediated pregnancy complications and bronchopulmonary dysplasia (BPD) in very preterm infants.

METHODS:

National prospective population-based cohort study including 2697 singletons born before 32 weeks’ gestation. The main outcome measure was moderate to severe BPD. Three groups of placenta-mediated pregnancy complications were compared with no placenta-mediated complications: maternal disorders only (gestational hypertension or preeclampsia), fetal disorders only (antenatal growth restriction), and both maternal and fetal disorders.

RESULTS:

Moderate to severe BPD rates were 8% in infants from pregnancies with maternal disorders, 15% from both maternal and fetal disorders, 23% from fetal disorders only, and 9% in the control group (P < .001). When we adjusted for gestational age, the risk of moderate to severe BPD was greater in the groups with fetal disorders only (odds ratio [OR] = 6.6; 95% confidence interval [CI], 4.1–10.7), with maternal and fetal disorders (OR = 3.7; 95% CI, 2.5–5.5), and with maternal disorders only (OR = 1.7; 95% CI, 1.0–2.7) than in the control group. When we also controlled for birth weight, the relationship remained in groups with fetal disorders only (OR = 4.2; 95% CI, 2.1–8.6) and with maternal and fetal disorders (OR = 2.1; 95% CI, 1.1–3.9).

CONCLUSIONS:

Placenta-mediated pregnancy complications with fetal consequences are associated with moderate to severe BPD in very preterm infants independently of gestational age and birth weight, but isolated maternal hypertensive disorders are not. Fetal growth restriction, more than birth weight, could predispose to impaired lung development.
Benefits of Delayed Cord Clamping in Red Blood Cell Alloimmunization
Authors: Garabedian Charles , Rakza Thameur , Drumez Elodie , Poleszczuk Marion , Ghesquiere Louise , Wibaut Bénédicte , Depoortere Marie-Hélène , Vaast Pascal , Storme Laurent , Houfflin-Debarge Véronique
Published: February 2016

BACKGROUND AND OBJECTIVE:

Several studies have shown the benefits of delayed cord clamping (DCC) in preterm and in healthy newborns at short and long term. Our objective was to evaluate the potentials benefits and risks of DCC in red cell alloimmunization.

METHODS:

This was a comparative before/after study of all living born neonates followed after fetal anemia requiring in utero transfusion. DCC was defined as cord clamping 30 seconds after birth.

RESULTS:

We included a continuous series of 72 neonates: 36 without DDC (group 1) and 36 with DDC (group 2). Hemoglobin at birth was lower in group 1 (10.2 vs 13.4 g/dL, P = .0003); 7 (25%) neonates in group 1 vs 24 (70.6%) in group 2 had no anemia at birth (P = .004). The rate of transfusion was similar between the 2 groups. Postnatal exchange transfusions were more likely performed in the group without DCC than in the group with DCC (47.2% vs 19.4%, P = .0124). Delay between birth and first transfusion was higher in group 2 (0 [0–13] vs 1 [0–21], P = .0274). The maximum level of bilirubin, the rate of intensive phototherapy, and the total duration of phototherapy were similar in the 2 groups.

CONCLUSIONS:

This study highlights a significant benefit of DCC in anemia secondary to red blood cell alloimmunization with a resulting decreased postnatal exchange transfusion needs, an improvement in the hemoglobin level at birth and longer delay between birth and first transfusion with no severe hyperbilirubinemia.