bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvement of a cashing trainer assembly methodology for FPGA development in vocational education students
Authors: Suartini Tuti , Harja Sri Lestari , Sukandar Aan
Published: November 2022

Learning media is defined as a tool used in conveying learning messages to students. Teachers or lectures can use the media to stimulate thoughts, feelings, attention and abilities or skills, and one of them is the use of trainers. The development board FPGA  of trainer tools for skill learning in digital technology-based vocational education today has been a problem that obstructs the growth of experts in high-tech-based vocational field.The Spartan development board and its software can be used to elaborate the improvement of skill learning. This research analyse how the development board can be used to enhance students’ thinking skill. The trainer tools in the market lately are still in the form of a mother board that can be interfaced with various devices commonly used to perform various digital automation technology. This study elaborates the use of the cashing trainer assembly among electrical engineering students and mechanical engineering students in a joint project to assembly a development mother board.The learning media is also used in group training among the peers.Based on trials and observations made by researchers, the students as the object of research results, have not performed optimally to combine planning of cashing trainer assembly methodology and practice in the assembly.
Respuesta micorrizal de plántulas de cacao (Theobroma cacao L.) variedad FSV-094 a la aplicación de diferentes inóculos micorrizales
Authors: Sierra Escobar Jorge Alberto , Murcia Morales Hyeraldy
Published: November 2022

Se realizó un experimento en invernadero con el fin de evaluar la respuesta de plántulas Cacao (Theobroma cacao variedad FSV-094) a la aplicación de inóculos micorrizales, para el efecto se utilizó un diseño experimental completamente al azar, con cuatro tratamientos, tres  fuentes de inoculos multiesporicos micorrizales comerciales, Ab (Glomus spp, Scuttellospora spp y Entrophospora spp), Bs (Glomus spp, Acaulospora spp, Entrophospora spp, y Scutellospora spp) y Bl (Rhizophagus irregularis, R. clarus, R. aggregatus, R. proliferum y Claroideoglomus etunicatum), más el control (sin inocular), cada tratamiento se estableció en el mismo suelo que fue ajustado 0,02 mg L-1 de fósforo (P). Se emplearon como variables respuesta la masa seca aérea (MSA), la masa seca de raíces (MSR), la colonización micorrizal, el contenido de P foliar, y la respuesta micorrizal fueron evaluados.  Los resultados indicaron que todos los inóculos presentaron colonización, los mejores tratamientos fueron Ab y Bs con valores de 27 y 28% respectivamente. Aunque no hubo diferencias significativas, los tratamientos Ab y Bs siempre estuvieron con valores por encima en cuanto a MSA (3,4 y 3,7 g) y P foliar (0,25 y 0,2%). En cuanto a respuesta micorrizal, se encontró que cuando se inoculó con Bs y Ab la respuesta fue moderada (25 - 50%), y con Bl marginal (≤ 24%). Queda claro que el uso de HMA comerciales puede derivar en una respuesta diferencial de T. cacao variedad FSV-094. Por lo cual se sugiere realizar una evaluación al inóculo micorrizal en relación con el genotipo antes de utilizarlo masivamente para la producción de plántulas de cacao bajo invernadero.
Kinetics and Thermodynamics of the Pyrolysis of Waste Polystyrene over Natural Clay
Authors: Ali Ghulam , Nisar Jan
Published: November 2022

Due to the massive increase in polymer manufacture, there has been a remarkable increase in plastic waste. With fewer landfills being used to dump plastic waste each year, it is becoming increasingly important to use effective recycling methods for plastic waste decomposition. In the present work, waste polystyrene was degraded in the presence of natural clay (K0.02, Ca0.15 [Mg0.25, Al0.69, Fe0.06], [Si2.0, Al0.6] O6.8 (O10) nH2O). The waste polymer was pyrolyzed at different heating rates i.e., 5, 10, 15 and 20°C min-1 in an inert environment using nitrogen within the temperature range of 40 to 600°C. Thermogravimetric data were interpreted using various models, including fitting kinetic methods i.e., Coats-Redfern and model-free methods i.e., Ozawa-Flynn-Wall, Kissinger-Akahira-Sunose and Friedman method. The activation energy determined by Coats-Redfern, Ozawa-Flynn-Wall, Kissinger-Akahira-Sunose and Friedman models were in the range of 83.22-150.37, 74.52-133.71, 73.16-131.23, and 78.40-140.67 kJmol-1, respectively. Among them, the lowest activation energy for polystyrene degradation was observed using Kissinger-Akahira-Sunose method. The calculated kinetic parameters would be useful in determining the reaction mechanism of the solid-state reactions in a real system.
Teamwork Training With a Multiplayer Game in Health Care: Content Analysis of the Teamwork Principles Applied
Authors: van Peppen Lara , Faber Tjitske J E , Erasmus Vicki , Dankbaar Mary E W
Published: November 2022

Background

In health care, teamwork skills are critical for patient safety; therefore, great emphasis is placed on training these skills. Given that training is increasingly designed in a blended way, serious games may offer an efficient method of preparing face-to-face simulation training of these procedural skills.

Objective

This study aimed to investigate the teamwork principles that were used during gameplay by medical students and teamwork experts. Findings can improve our understanding of the potential of serious games for training these complex skills.

Methods

We investigated a web-based multiplayer game designed for training students’ interprofessional teamwork skills. During gameplay, 4 players in different roles (physician, nurse, medical student, and student nurse) had to share information, prioritize tasks, and decide on next steps to take in web-based patient scenarios, using one-to-one and team chats. We performed a qualitative study (content analysis) on these chats with 144 fifth-year medical students and 24 health care teamwork experts (as a benchmark study) playing the game in groups of 4. Game chat data from 2 scenarios were analyzed. For the analysis, a deductive approach was used, starting with a conceptual framework based on Crew Resource Management principles, including shared situational awareness, decision-making, communication, team management, and debriefing.

Results

Results showed that most teamwork principles were used during gameplay: shared situational awareness, decision-making (eg, re-evaluation), communication (eg, closed loop), and team management (eg, distributing the workload). Among students, these principles were often used on a basic level. Among experts, teamwork principles were used with more open forms of speak up and more justification of decisions. Some specific Crew Resource Management principles were less observed among both groups, for example, prevention of fixation errors and use of cognitive aids. Both groups showed relatively superficial debriefing reflections.

Conclusions

Playing a multiplayer game for interprofessional teamwork appears to facilitate the application of teamwork principles by students in all important teamwork domains on a basic level. Expert players applied similar teamwork principles on a moderately high complexity level. Some teamwork principles were less observed among both students and expert groups, probably owing to the artifacts of the game environment (eg, chatting instead of talking). A multiplayer game for teamwork training can elicit the application of important, basic teamwork principles, both among novices and experts, and provides them with a flexible, accessible, and engaging learning environment. This may create time for exercising more complex skills during face-to-face training.
End User Participation in the Development of an Ecological Momentary Intervention to Improve Coping With Cannabis Cravings: Formative Study
Authors: Anderson Molly A , Budney Alan J , Jacobson Nicholas C , Nahum-Shani Inbal , Stanger Catherine
Published: November 2022

Background

Cannabis misuse in young adults is a major public health concern. An important predictor of continued use is cannabis craving. Due to the time-varying nature of cravings, brief momentary interventions delivered while cravings are elevated may improve the use of strategies to cope with cravings and reduce cannabis use.

Objective

The goal of this manuscript is to describe a formative study to develop coping strategy messages for use in a subsequent intervention.

Methods

Young adults (aged 19-25 years; n=20) who reported using cannabis >10 of the past 30 days recruited via social media participated in this formative study. Participants rated an initial set of 15 mindfulness and 15 distraction coping strategies on a scale from 1 to 4 (very low degree to very high degree) for clarity, usefulness, and tone. They also provided comments about the content.

Results

Participants found the initial distraction messages slightly clearer than mindfulness (mean 3.5, SD 0.4 and mean 3.4, SD 0.4, respectively), both were comparable in tone (mean 3.2, SD 0.5 and mean 3.2, SD 0.4, respectively), and mindfulness messages were more useful than distraction (mean 3.0, SD 0.5 and mean 2.8, SD 0.6, respectively). Of the 30 messages, 29 received a rating of very low or low (<2) on any domain by >3 participants or received a comment suggesting a change. We revised all these messages based on this feedback, and the participants rated the revised messages approximately 2 weeks later. Participants earned US $10 for completing the first and US $20 for the second survey. The ratings improved on usefulness (especially the distraction items) with very little change in clarity and tone. The top 10 messages of each coping type (mindfulness and distraction) were identified by overall average rating (collapsed across all 3 dimensions: all rated >3.0). The final items were comparable in clarity (distraction mean 3.6, SD 0.4; mindfulness mean 3.6, SD 0.4), tone (distraction mean 3.4, SD 0.4; mindfulness mean 3.4, SD 0.4), and usefulness (distraction mean 3.1, SD 0.5; mindfulness mean 3.2, SD 0.5).

Conclusions

The inclusion of end users in the formative process of developing these messages was valuable and resulted in improvements to the content of the messages. The majority of the messages were changed in some way including the removal of potentially triggering language. These messages were subsequently used in an ecological momentary intervention.
Differences in Brain Activity and Body Movements Between Virtual Reality and Offline Exercise: Randomized Crossover Trial
Authors: Kim Hee Jin , Lee Jea Woog , Choi Gangta , Huh Junghoon , Han Doug Hyun
Published: November 2022

Background

Virtual reality (VR) has been suggested to be effective at enhancing physical exercises because of its immersive characteristics. However, few studies have quantitatively assessed the range of motion and brain activity during VR exercises.

Objective

We hypothesized that 3D immersive VR could stimulate body movement and brain activity more effectively than standard exercises and that the increased range of motions during 3D immersive VR exercises would be associated with orbitofrontal activation.

Methods

A randomized crossover trial was conducted to compare exercises with and without VR. A total of 24 healthy males performed the same motions when exercising with and without 3D immersive VR, and the recorded videos were used for motion analysis. Hemodynamic changes in the prefrontal cortex were assessed using functional near-infrared spectroscopy.

Results

There were significant differences in the total angle (z=−2.31; P=.02), length (z=−2.78; P=.005), calorie consumption (z=−3.04; P=.002), and change in accumulated oxygenated hemoglobin within the right orbitofrontal cortex (F1,94=9.36; P=.003) between the VR and offline trials. Hemodynamic changes in the right orbitofrontal cortex were positively correlated with the total angle (r=0.45; P=.001) and length (r=0.38; P=.007) in the VR exercise; however, there was no significant correlation in the offline trial.

Conclusions

The results of this study suggest that 3D immersive VR exercise effectively increases the range of motion in healthy individuals in relation to orbitofrontal activation.

Trial Registration

Clinical Research Information Service KCT0008021; https://cris.nih.go.kr/cris/search/detailSearch.do/23671
Co-design and Development of EndoSMS, a Supportive Text Message Intervention for Individuals Living With Endometriosis: Mixed Methods Study
Authors: Sherman Kerry Anne , Pehlivan Melissa Jade , Singleton Anna , Hawkey Alexandra , Redfern Julie , Armour Mike , Dear Blake , Duckworth Tanya Jane , Ciccia Donna , Cooper Michael , Parry Kelly Ann , Gandhi Esther , Imani Sara A
Published: November 2022

Background

Endometriosis, which affects 1 in 10 people assigned female at birth, is a chronic systemic inflammatory disease with a high symptom burden and adverse socioemotional impacts. There is a need for an accessible, cost-effective, and low-burden intervention to support individuals in managing their endometriosis condition.

Objective

This study aimed to co-design and evaluate the acceptability, readability, and quality of a bank of supportive SMS text messages (EndoSMS) for individuals with endometriosis.

Methods

In phase 1 of this mixed method design, 17 consumer representatives (individuals with endometriosis) participated across three 3-hour web-based (Zoom, Zoom Video Communications, Inc) focus groups. The transcripts were encoded and analyzed thematically. In phase 2, consumer representatives (n=14) and health care professionals (n=9) quantitatively rated the acceptability, readability, and appropriateness of the developed text messages in a web-based survey. All the participants initially completed a background survey assessing sociodemographic and medical factors.

Results

Consumer representatives demonstrated diverse sociodemographic characteristics (Mage=33.29), varying in location (metropolitan vs rural or regional), employment, and relationship and educational statuses. Participants reached a consensus regarding the delivery of 4 SMS text messages per week, delivered randomly throughout the week and in one direction (ie, no reply), with customization for the time of day and use of personal names. Seven main areas of unmet need for which participants required assistance were identified, which subsequently became the topic areas for the developed SMS text messages: emotional health, social support, looking after and caring for your body, patient empowerment, interpersonal issues, general endometriosis information, and physical health. Through a web-based survey, 371 co-designed SMS text messages were highly rated by consumers and health care professionals as clear, useful, and appropriate for individuals with endometriosis. Readability indices (Flesch-Kincaid scale) indicated that the SMS text messages were accessible to individuals with a minimum of 7th grade high school education.

Conclusions

On the basis of the needs and preferences of a diverse consumer representative group, we co-designed EndoSMS, a supportive SMS text message program for individuals with endometriosis. The initial evaluation of the SMS text messages by consumer representatives and health professionals suggested the high acceptability and suitability of the developed SMS text messages. Future studies should further evaluate the acceptability and effectiveness of EndoSMS in a broader population of individuals with endometriosis.
Predictors of Mental Health Literacy in a Sample of Health Care Major Students: Pilot Evaluation Study (Preprint)
Authors: Tohme Pia , Abi Fadel Nour , Yaktine Nour , Abi-Habib Rudy
Published: November 2022

BACKGROUND

The numerous mental health awareness campaigns during the COVID-19 pandemic have shifted our understanding and perception of mental health.

OBJECTIVE

The purpose of this study is to evaluate predictors of mental health literacy (MHL), that is, one’s knowledge and beliefs about mental disorders. We evaluate whether digital health literacy, empathy, and mentalizing contribute to MHL.

METHODS

Our sample consisted of 89 health care major students, aged between 17 and 32 years, studying at a university in Lebanon. The Mental Health Literacy Scale for Healthcare Students (MHLS-HS), the eHealth Literacy Questionnaire (eHLQ), the Basic Empathy Scale (BES), and the Reflective Functioning Questionnaire-8 (RFQ-8) were used.

RESULTS

Multiple regression analyses revealed that the Engagement in Own Health subscale of digital health literacy constituted a predictor of MHL. While empathy and mentalizing did not directly predict MHL, they were found to predict components of MHL.

CONCLUSIONS

This is the first study to evaluate digital health literacy, empathy, and mentalizing as predictors of MHL in Lebanon, a country where mental health is still considered taboo. Moreover, this pilot study is the first to provide some support for the predictive role of some digital health literacy subscales on MHL in light of the rise of the digital era following the COVID-19 pandemic.

CLINICALTRIAL
Exploring Stakeholder Requirements to Enable Research and Development of Artificial Intelligence Algorithms in a Hospital-Based Generic Infrastructure: Results of a Multistep Mixed Methods Study (Preprint)
Authors: Weinert Lina , Klass Maximilian , Schneider Gerd , Heinze Oliver
Published: November 2022

BACKGROUND

Legal, controlled, and regulated access to high-quality data from academic hospitals currently poses a barrier to the development and testing of new artificial intelligence (AI) algorithms. To overcome this barrier, the German Federal Ministry of Health supports the “pAItient” (Protected Artificial Intelligence Innovation Environment for Patient Oriented Digital Health Solutions for developing, testing and evidence-based evaluation of clinical value) project, with the goal to establish an AI Innovation Environment at the Heidelberg University Hospital, Germany. It is designed as a proof-of-concept extension to the preexisting Medical Data Integration Center.

OBJECTIVE

The first part of the pAItient project aims to explore stakeholders’ requirements for developing AI in partnership with an academic hospital and granting AI experts access to anonymized personal health data.

METHODS

We designed a multistep mixed methods approach. First, researchers and employees from stakeholder organizations were invited to participate in semistructured interviews. In the following step, questionnaires were developed based on the participants’ answers and distributed among the stakeholders’ organizations. In addition, patients and physicians were interviewed.

RESULTS

The identified requirements covered a wide range and were conflicting sometimes. Relevant patient requirements included adequate provision of necessary information for data use, clear medical objective of the research and development activities, trustworthiness of the organization collecting the patient data, and data should not be reidentifiable. Requirements of AI researchers and developers encompassed contact with clinical users, an acceptable user interface (UI) for shared data platforms, stable connection to the planned infrastructure, relevant use cases, and assistance in dealing with data privacy regulations. In a next step, a requirements model was developed, which depicts the identified requirements in different layers. This developed model will be used to communicate stakeholder requirements within the pAItient project consortium.

CONCLUSIONS

The study led to the identification of necessary requirements for the development, testing, and validation of AI applications within a hospital-based generic infrastructure. A requirements model was developed, which will inform the next steps in the development of an AI innovation environment at our institution. Results from our study replicate previous findings from other contexts and will add to the emerging discussion on the use of routine medical data for the development of AI applications.

INTERNATIONAL REGISTERED REPORT

RR2-10.2196/42208
Assessment of the wind power plants role in CO2 emissions reducing and energy supply in the regions of Russia
Authors: Nefedova L. , Degtyarev K. , Berezkin Mikhail
Published: November 2022

The article contains an analysis of the share of mayor wind power plants in regional energy mixes and evaluation of their contribution to CO2 emission reducing, basing on the data for wind capacities construction and launch. The estimations showed that wind plants in Republic of Kalmykia could cover more than 94% of industrial and household electricity demand. Forecast evaluations for the wind plants planned to be put into operation until 2024 demonstrate a high wind potential for satisfaction of energy demand in Republics of Kalmykia and Adygeya as well as in Ulyanovsk and Astrakhan regions. The decrease in CO2 emissions in the regions of Russia was estimated by 2024 due to the absence of emissions at wind farms in the amount of 4.5 million tons per year.
Distribution, ecological and biological features and the state of cenopopulations of species of the genus Cephalanthera Rich. (Republic of Adygea)
Authors: Sirotyuk E. , Gunina G. , Khiryanov V.
Published: November 2022

There are three species of the genus Cephalanthera in the Republic of Adygea. All species are rare and listed in the Red Book of the Republic. They grow in forests of various types at altitudes from 209 m to 1724 m above sea level. The review provides a brief morphological description and some features of biology and ecology. Special attention is paid to identifying the locations of species, their phytocenotic association, analyzing the ontogenetic structure of cenopopulations and assessing their condition. Limiting factors were identified and possible ways of preserving the cenopopulation diversity of species were recommended.
Creation of Variation through In-vitro Mutagenesis using Gamma radiation in Rose (Rosa hybrida L.) Variety ‘Lửa’
Authors: Le Nguyen Lan Thanh , Nguyen Van Son , Le Van Hoa
Published: November 2022

Rosa hybrida L. var. Lửa has been one of the most important roses for a long time and is most often used for ornamental purposes in Sadec city, Dong Thap province. The study aimed to induce variation through in-vitro gamma-ray irradiation in the rose variety ‘Lửa’ for further improvement in rose breeding. In-vitro single node cuttings (25 in-vitro cuttings per treatment with four replications) were irradiated with different doses of γ-rays (0, 5, 10, 15, 20, 25, or 30 Gy) using a 60Co source (India) at Da Lat Nuclear Research Institute. The γ-irradiated explants were then cultured aseptically on Murashige and Skoog’s basal medium supplemented with 1.0 mg/L BAP to induce multiple shoots, shoot proliferation, and acclimatization at Division of Vegetables, Flowers and Landscaping of Southern Horticultural Research Institute (SOFRI). The LD50 dose was determined at 20 - 25 Gy treatments and these doses affected the multiplication rate, growth in-vitro, and ex-vitro survival rate. Three types of mutants with altered or novel flower color in comparison to the original flower color were isolated, such as Type 1 with orange-pink (Red 52C), Type 2 with pink (Red 54B), and Type 3 with Red 45AB with Red 54B bicolor.
Diversity of medicinal plant resources in Lai Son island, Kien Giang province
Authors: Dang Minh Quan , Nguyen Trong Hong Phuc
Published: November 2022

This study was conducted with the aim of assessing the diversity of medicinal plants in Lai Son Island, Kien Giang province, which is a scientific basis for more effectively using, managing, and preserving this medicinal plant resource in this province. In this study, the PRA (Participatory Rural Appraisal), field investigation, morphological comparison, and classification, with the aid of specialized medicinal plant books were used. The results showed a total of 353 species of medicinal plants belonging to 264 genera of 112 families in 4 divisions. Among them, Magnoliophyta was the most diverse division with 94.90% % species, 95.08% genera, and 90.18% families. Seven species were listed in “Red List of Vietnamese medicinal plants” (2006), “Vietnam Red Book” (2007), and the Decree 06/2019/ND-CP. The medicinal plant species were divided into ten life forms and distributed in six biotopes. The most species diversity was recorded in the natural forest on rocky mountain biotope. Ten parts of plants were used to medicate 36 disease types. Twenty-four species were commonly used by local people.
Pemodelan Epidemiologi Kejadian Multidrug Resistance Bakteri Escherichia coli pada Peternakan Ayam Komersial di Kabupaten Blitar
Authors: Wibisono Freshinta Jellia , Sumiarto Bambang , Untari Tri , Effendi Mustofa Helmi , Permatasari Dian Ayu , Witaningrum Adiana Mutamsari
Published: November 2022

Sifat resistensi bakteri Escherichia coli terhadap antibiotik mengakibatkan terbatasnya pilihan pengobatan. Perkembangan lebih lanjut dari resistensi bakteri dapat menyebabkan munculnya multidrug resistance pada bakteri, sehingga meningkatkan morbiditas dan mortalitas penyakit. Interaksi penyebaran kejadian multidrug resistance pada Escherichia coli yang terjadi pada populasi sangat kompleks, sehingga sulit memahami dinamika penyebaran berskala besar.  Pendekatan pemodelan menjadi sangat penting untuk pengambilan keputusan tentang program pengendalian penyakit infeksi. Penelitian ini merupakan penelitian epidemiologi deskriptif analitik dengan desain cross-sectional study. Metode analisis menggunakan analisis regresi logistic untuk mendapatkan pemodelan kejadian multidrug resistance bakteri Escherichia coli pada tingkat ternak, dan menggunakan regresi linier untuk mendapatkan pemodelan kejadian multidrug resistance bakteri Escherichia coli pada tingkat peternakan. Hasil dari penelitian ini menunjukkan Distribusi kasus kejadian multidrug resistance pada ayam komersial di Kabupaten Blitar menunjukkan prevalensi kejadian pada tingkat peternakan sebesar 95.9%. Pemodelan kejadian multidrug resistance bakteri Escherichia coli tingkat ternak menghasilkan model regresi logistik ganda Ln () = 0.21964 + 1.60374 RefTS + 1.44989 Broiler + 0.96022 PakRacik + 0.84182 ProgAb – 1.16667 SaniKan – 1.15046 Tritendap, dengan peluang kejadian sebesar 94 %. Pemodelan kejadian Multidrug resistance bakteri Escherichia coli tingkat peternakan menghasilkan model regresi linier, MDR (Y) = 0.57886 + 0.16105 JUMitra + 0.19342 ProgAb – 0.16178 Dukudrh. Model ini memiliki wilk saphiro mendekati 1 (W = 0,9573) sehingga model persamaan ini merupakan model yang baik untuk kejadian Multidrug resistance bakteri Escherichia coli tingkat peternakan.
Studi Histopatologi Ren Tikus Putih (Rattus Norvegicus L.) Diabetes Setelah Pemberian Cuka dari Kulit Nanas (Ananas Comosus (L.) Mer.)
Authors: Annisa Tazkia , Sitasiwi Agung Janika , Isdadiyanto Sri , Jannah Siti Nur
Published: November 2022

Diabetes mellitus is a metabolic disease that occurs due to impaired insulin secretion caused by progressive damage to beta cells. Pineapple skin vinegar contained acetic acid and antioxidants which have the potential to help repaired the structure of the nephron ren and other organs affected by diabetes. The purpose of this study was to examined the effectiveness of pineapple skin vinegar on improved the histological structure of diabetic rats ( Rattus norvegicus L.). This study based on changed in the structure of the nephron in samples of normal and alloxan-induced mice pre-treatmented and post-treatmented. Twenty-four rats were divided into 6 groups, named normal control, positive control (diabetes + 0.4 mL apple vinegar), negative control (diabetes + water), dose test groups 1, 2, and 3 (pineapple vinegar 0.2 mL; 0.4 mL; 0.8 mL). Statistical analysis test used ANOVA was followed by Duncan test. The conclusion of this research, the pineapple skin vinegar showed the ability to repair the histopathological structure of white rats damaged by diabetes. The optimum dose needed was 0.8 mL to improved the histological structure of the nephron, as indicated by the glomerular diameter and the distance of the Bowman's capsule space to near normal.
Kajian Daun Sirih Hijau (Piper betle L) Sebagai Antibakteri
Authors: Sadiah Hilma Halimatus , Cahyadi Adi Imam , Windria Sarasati
Published: November 2022

AbstractBacterial infection is one of the biggest health issues in animals and humans. Antibiotic is commonly used in bacterial infection therapy, yet antibiotic misuse can lead into bacterial antibiotic resistance. This means antibiotic is less effective in therapy of resistant bacteria. Green betel leaf has been known as traditional herbal medicine with rich essential oil and consists of phenol with several derivatives that have antibacterial activity. The results of the research that have been carried out can be reported that green betel leaf has the potential to be antibacterial. This herbal can be used as alternative therapy because it is easy to get and have low-level toxicity. In this study we try to discuss about green betel leaf (Piper betle L) as antibacterial with activity against Gram-positive and Gram-negative bacteria by analyzing the component of the active compound and mechanism of action.keywords: antibacterial activity; green betel leaf; Piper betle L AbstrakInfeksi bakteri menjadi masalah yang sudah sering terjadi dan berdampak buruk bagi kesehatan manusia dan hewan. Pengobatan untuk penyakit infeksi biasanya menggunakan antibiotik, namun banyak penggunaan antibiotik yang disalahgunakan sehingga dapat mengakibatkan terjadinya resistensi dan bakteri menjadi tidak sensitif terhadap pengobatan antibiotik. Daun sirih hijau merupakan salah satu obat tradisional yang memiliki kandungan minyak atsiri dan komponen utamanya terdiri fenol dengan beberapa turunannya yang berperan sebagai antibakteri. Hasil dari penelitian yang telah dilakukan dapat dinyatakan bahwa daun sirih hijau dapat berpotensi sebagai antibakteri. Selain itu daun sirih hijau mudah didapat dan memiliki toksisitas rendah yang menyebabkan tanaman tradisional tersebut dijadikan sebagai alternatif dalam mengobati infeksi bakteri. Studi literatur ini membahas daun sirih hijau (Piper betle L) sebagai antibakteri terhadap bakteri Gram positif dan Gram negatif meliputi komponen senyawa aktif dan mekanismenya.Kata kunci : aktivitas antibakteri; daun sirih hijau; Piper betle L
Efektivitas Low Density Lipoprotein (LDL) dari Kuning Telur Ayam terhadap Kualitas Semen Cair Domba
Authors: Citraesti Dwitya , Prasetyaningtyas Wahono Esthi , Karja Ni Wayan Kurniani
Published: November 2022

Low-Density Lipoprotein (LDL) extracted from egg yolk (LDL) has recently known can eliminate the adverse effect associated in the use of fresh egg yolk. The role of LDL in liquid preservation at 4°C of ram sperm has not been explored. This research evaluates the effects of substituting egg yolk with LDL in ram sperm preservation at 4 °C on 5 days. The objective of this research was to assess the effects of substituting egg yolk with LDL for use as an extender in sperm preservation at 4°C, as well as on spermatozoa motility, viability, morphology, plasma membrane, and acrosome integrity, for 5 days. The semen was subsequently divided into five and diluted with Tris–fresh egg yolk (K), Tris–LDL5% (LDL5), Tris–LDL10% (LDL10), Tris–LDL15% (LDL15), and Tris–LDL20% (LDL20). The result showed a significant difference between LDL to fresh egg yolk for ram sperm quality (P<0.05). The effectiveness of LDL on sperm quality decreased following by its concentration. Even though up to 20% concentration of LDL, it can not preserve the quality of diluted semen for motility, viability, and plasm membrane integrity.
Kajian Profil Hormon Estradiol Berdasarkan Perkembangan Folikel dan Ovarium Sapi Tropis Postpartus
Authors: Alfons Mandala Phivi Whelma , Budiyanto Agung , Setyawan Erif Maha Nugraha
Published: November 2022

Organ reproduksi sapi postpartus menjalani serangkaian proses fisiologis dan anatomis, untuk kembali ke kondisi normal tidak bunting. Recovery organ reproduksi dapat dibuktikan dengan perkembangan folikel, ovarium dan estradiol. Penelitian ini bertujuan untuk mendeteksi kadar estradiol dalam darah berdasarkan dinamika perkembangan folikel dan ovarium pada sapi potong tropis postpartus. Riset ini menggunakan 16 ekor sapi potong jenis Peranakan Ongole (PO) (n=8) dan Crossbreed (CB) (n=8), multipara, partus normal, sehat, umur 3-10tahun dan SKT 2.5-3.5.Pengukuran folikel dan ovarium menggunakan ultrasonografi (USG) dan pengambilan darah melalui vena jugularissecara periodikdimulai pada minggu ke-1, 5, 9, 13, 17.Hasil penelitian menunjukkan diameter folikel terendah pada minggu ke-5 (PO=3.5±0.2 mm dan CB=3.2±0.2 mm) dan tertinggi di minggu ke-17 (PO=5.3±0.7 mm dan CB=5.1±0.5 mm). Hasil pengukuran rata-rata diameter ovarium sapi PO dan CB berkisar 20.0±1.0-24.2±1.6 mm. Analisis estradiol menggunakan metode Enzym-linked immunosorbent assay. Hasil analisis estradiol dari minggu ke-5 sampai 17 berkisar 30.3±2.9-49.5±8.8 pg/ml. Diameter folikel, ovarium dan kadar estradiol diklasifikasikan menjadi 3 grup. Grup satu dengan ukuran diameter folikel ≤ 2.0 mm dan ovarium ≤ 20.0 mm menghasilkan rata-rata kadar estradiol sebesar 22.8±1.7 pg/ml. Grup dua diklasifikasikan ukuran diameter folikel 3.0-5.0 mm dan ovarium 21.0-25.0 mm, menghasilkan rata-rata estradiol 38.9±2.0 pg/ml. Grup tiga diklasifikasikan ukuran diameter folikel 6.0-9.0 mm dan ovarium 26.0-30.0 mm menghasilkan rata-rata estradiol sebanyak 61.1±6.0 pg/ml. Kesimpulan penelitian ini adalah perkembangan folikel dan kadar estrogen merupakan faktor yang mempengaruhi kembalinya estrus postpartus. Perkembangan folikel yang belum sempurna mengakibatkan produksi estradiol tidak optimal sehingga belum mampu menginisiasi estrus
Combination of Acupuncture Points in The Treatment of Hind Leg Paresis with Electroacupuncture Methods in Domestic Cats
Authors: Ritonga Mudhita Zikkrullah , Siregar Tongku Nizwan , Hanafiah M , - Muttaqien , Putri Elvina Andali
Published: November 2022

Back leg paresis is muscle weakness that can cause the inability to walk or support the back of the body. A domestic cat, female, black tabby hair colour with a bodyweight of 2.9 kg has weakness in both hind legs so it cannot lift the back of the body properly but there is still a reflex when pressing using tweezers sirurgis on the gluteus muscle tendon. The flexor reflexes on the digits are still present but slightly. From the physical examination, it was concluded that there was a disturbance in the segment IV spinal cord, precisely at L7-S1. Cats also experience problems with defecation, namely the patient's stool is watery inconsistency. The results of the X-Ray examination showed that the segments of the os. lumbar, os. femur, os. tibia, os. fibula, os. metatarsal to digit there are no fractures and also the visceral organs do not experience changes and abnormalities. However, there is a bias picture, namely compression on the 7th segment (S4-L5, L6 and L7). The diagnosis was that the cat had disorders of the spinal cord segments IV (L4-S2) and V, to be precise, from L7 to S2. Electroacupuncture therapy at points BL-18, BL-19, SP-6, ST-36 and LIV-3 was carried out for three weeks, namely twice in the first week and once in the second and third weeks. Oral drug therapy in the form of Neurobion® tablets is taken orally during therapy.
KAJIAN PUSTAKA: AKTIVITAS ANTIBAKTERI DARI BAKTERIOSIN Lactobacillus spp. TERHADAP BAKTERI RESISTAN
Authors: Shavira Allysa , Cahyadi Adi Imam , Windria Sarasati
Published: November 2022

Resistensi antibiotik merupakan isu yang genting dijadikan topik penelitian beberapa tahun belakangan ini, dimana salah satu penyebab terjadinya resistensi antibiotik adalah penggunaan antibiotik secara terus menerus dengan dosis yang tidak tepat. Salah satu alternatif yang memiliki peluang untuk melawan bakteri resisten adalah dengan menggunakan bakteriosin. Bakteriosin merupakan senyawa protein yang secara biologis aktif, memiliki berat molekul kecil dan memiliki sifat antibakteri yang umumnya bersifat bakterisidal. Penelitian ini dilakukan dengan metode kajian pustaka dari literatur yang sesuai dengan topik penelitian. Hasil penelitian menunjukkan bahwa bakteriosin banyak dihasilkan oleh bakteri asam laktat, salah satunya dari genus Lactobacillus, seperti L. paracasei, L. plantarum, L. coryniformis, dan L. crustorum, yang memiliki karakteristik menguntungkan seperti stabil terhadap pH dan suhu dan mampu bekerja pada spektrum luas dengan menghambat pertumbuhan bakteri Gram-positif dan Gram-negatif yang resistan terhadap antibiotik, dan pada umumnya memiliki mekanisme antibakteri melalui pembentukan pori-pori yang akan mempengaruhi permeabilitas membran sel dan pada akhirnya menyebabkan kematian sel
POLA PEMELIHARAAN BURUNG WALET PADA PULAU-PULAU UTAMA PENGHASIL SARANG BURUNG WALET DI INDONESIA
Authors: Wahyuni Dede Sri , Latif Hadri , Sudarwanto Mirnawati B , Basri Chaerul
Published: November 2022

Burung walet di Indonesia umumnya dibudidayakan pada rumah burung walet (RBW) secara tradisional dengan pola pemeliharaan tertentu. Pola pemeliharaan menjadi salah satu faktor pendukung bagi burung walet untuk memproduksi sarang burung walet (SBW) dengan kualitas baik secara berkelanjutan. Penelitian ini bertujuan untuk menganalisis pola pemeliharaan burung walet di RBW di pulau-pulau utama penghasil SBW di Indonesia. Suatu survei terhadap total 44 RBW di pulau Jawa, Sumatera, Sulawesi, dan Kalimantan telah dilakukan untuk mengetahui pola pemeliharaan di masing-masing pulau tersebut. Data dikumpulkan melalui wawancara secara langsung dengan menggunakan kuesioner terstruktur. Pertanyaan dalam kuesioner terdiri atas karakteristik bangunan, kebersihan, sumber makanan dan udara, dan lingkungan RBW. Hasil penelitian menunjukkan bahwa bangunan RBW umumnya bertingkat, dengan atap beton, dinding bata semen, lantai plester semen, dan sirip kayu. Rumah burung walet dibersihkan dibersihkan dengan cara digores/disapu dalam waktu kurang dari dua bulan. Kotoran burung walet umumnya digunakan untuk kebutuhan sendiri. Rumah burung walet umumnya tidak menyediakan bahan untuk menarik serangga atau pakan tambahan. Pakan burung walet umumnyaHymenoptera , dan sumber airnya adalah kolam di dalam gedung RBW. Lingkungan RBW merupakan kawasan pemukiman dan dekat dengan jalan raya. Pembinaan dan pemantauan terhadap pola pemeliharaan burung walet perlu terus dilakukan untuk mendapatkan SBW yang berkualitas baik.
Uji In Vitro Efektivitas Ekstrak Biji Jintan Hitam (Nigella Sativa L.) terhadap Pertumbuhan Microsporum gypseum Penyebab Dermatitis pada Anjing
Authors: Glabella Pasha , Putri Salma Ramandhanti , Haryani Ery , Wahyuni Agnesia Endang Tri Hastuti
Published: November 2022

Biji jintan hitam (Nigella sativa L.) mengandung senyawa aktif seperti thymoquinone, carvacrol, dan thymol yang berperan sebagai antijamur. Penelitian ini bertujuan untuk mengetahui kemampuan ekstrak biji jintan hitam dalam menghambat pertumbuhan jamur Microsporum gypseum yang merupakan salah satu agen penyebab dermatitis pada anjing. Kemampuan ekstrak biji jintan hitam dalam menghambat pertumbuhan jamur Mircrosporum gypseum diuji dengan metode difusi agar dengan teknik sumuran (Agar Well Diffusion). Rancangan penelitian ini menggunakan Rancangan Acak Lengkap (RAL) dengan 7 perlakuan konsentrasi ekstrak biji jintan hitam terhadap pertumbuhan jamur Microsporum gypseum yaitu 10%, 25%, 50%, 75%, 100%, flukonazol digunakan sebagai kontrol positif dan phospat buffer saline (PBS) kontrol negatif. Hasil penelitian menunjukkan bahwa ekstrak biji jintan hitam dengan konsentrasi mulai dari 25%, 50%, 75% dan 100% dapat menghambat pertumbuhan jamur dengan rerata lebar zona hambat secara berurutan ± 3,67 mm., ± 2,84 mm., ± 3,67 mm., dan ± 4,00 mm. Ekstrak biji jintan hitam mampu menghambat pertumbuhan Microsporum gypseum.  Perlu penelitian lebih lanjut untuk mendapatkan hasil optimal sehingga berpeluang sebagai anti fungal pada penyakit dermatitis pada anjing.
Climate and the Nephrologist
Authors: Young Sarah E. , Khoshnaw Laveen J. , Johnson Richard J.
Published: November 2022

Climate change is upon us, and it will have a major effect on both kidney disease and the nephrology practice. But the converse is also true: our treatment of kidney disease has an effect on the climate. Much attention has focused on how rising temperatures can lead to acute and CKD and health exacerbations in patients with established kidney disease. Climate change is also associated with rising air pollution from wildfires and industrial wastes and infectious diseases associated with flooding and changing habitats, all of which heighten the risk of acute and CKD. Less well recognized or understood are the ways nephrology practices, in turn, contribute to still more climate change. Hemodialysis, although lifesaving, can be associated with marked water usage (up to 600 L per dialysis session), energy usage (with one 4-hour session averaging as much as one fifth of the total energy consumed by a household per day), and large clinical wastes (with hemodialysis accounting for one third of total clinical medicine–associated waste). Of note, >90% of dialysis occurs in highly affluent countries, whereas dialysis is much less available in the poorer countries where climate change is having the highest effect on kidney disease. We conclude that not only do nephrologists need to prepare for the rise in climate-associated kidney disease, they must also urgently develop more climate-friendly methods of managing patients with kidney disease.
Moszkowski’s “Caprice Espagnol” Piano Playing Techniques Exploration
Authors: Yang Lingli
Published: November 2022

Moritz Moszkowski is a famous European renowned Polish composer, conductor, pianist and educator. His creation involves many aspects, among which the most numerous and the most well-known is the piano works, in these piano works is good for using Spanish folk music elements to create. In this paper through the Moszkowski piano “Spanish style” creative background, creative characteristics and playing techniques, make us to the writing background, creative characteristics and piano playing techniques have a certain grasp and more profound understanding, and the charm of the work to form a deeper understanding, more thorough experience, so as to form a better effect in the process of interpretation.
IN SILICO APPROACH TARGETING POLYPHENOL AS FABH INHIBITOR IN BACTERIAL INFECTION
Authors: DHAWALE SACHIN , GAWALE SACHIN , JADHAV AKASH , GETHE KALYANI , RAUT PRASHANT , HIWARALE NIKITA , BHOSALE PALLAVI , TAPADIYA GANESH
Published: November 2022

Objective: The aim of the study is to perform a computational study consisting of molecular docking for polyphenols subjected to in silico studies to identify a new lead for antimicrobial activity which has been reported yet or not been used yet.
Methods: The Schrödinger Maestro 11.3 performed molecular docking of the enzyme FabH (β-ketoacyl-acyl carrier protein synthase III) (PDB ID: 5BNR) with polyphenol. The targeted compounds were docked against FabH enzyme and also evaluated for MM-GBSA and ADMET analysis.
Results: The top hits shows remarkable results and good binding interactions with a pocket of the enzyme. The best binding score are as-8.6 (kcal/mol) of Geniestein,-8.579 (kcal/mol) of 4-naphthoquinone,-7.651(kcal/mol) of Pelargonidin. All the targeted compounds were found in the given limits of ADMET parameters. They also showed good free-binding energy.
Conclusion: The computational study reveals that the targeted polyphenols show good binding interactions and are also compatible with ADMET parameters. So, with this, we can conclude that the reported polyphenols can be potent against bacterial infection. In the future, if we derivatized these polyphenols with different substitutions, it can also lead to a potential drug moiety against bacterial infection.
Challenges of MSME in Manipur Post Covid-19: A Pilot Study
Authors: Dangmei Dr. Jianguanglung , Singh Prof. Amarendra Pratap
Published: November 2022

The Covid-19 epidemic had affected every economic sector, but nowhere are they affected as severely as the MSMEs in India. MSMEs realise that they must develop and change over time in order to remain competitive. The purpose of this study is to determine the extent of challenges posed by MSMEs of Manipur after COVID-19 and to make recommendations for solutions to ensure their viability during these trying times. It also aids in understanding and identifying the numerous problems these enterprises are currently experiencing. The findings in this research have significant ramifications that will enable the economy to recover from its crisis. As a result, the research intends to present data that will evaluate the MSME in this period by outlining the challenges. It was found that the biggest challenges include market competition from larger corporations, product costs, poor infrastructure, and a lack of technical expertise. The overall level of challenges faced by the MSME of Manipur is also high. The challenges that the MSME faces are essentially the same for both male and female. Therefore, MSMEs in Manipur can strengthen their position in the global market by strong emphasis on increasing exports and creating domestic demand that is necessary for the MSMEs sector to quickly recover through advancements and innovation in technology, infrastructures and products.
Centro de articulación productiva apícola en Quintana Roo: análisis de la cadena de valor
Authors: González Fonseca Fredy Ismael , Abraham Sánchez Miguel Ángel
Published: November 2022

Objetivo: analizar la factibilidad de diseñar un centro de articulación productiva para la actividad apícola del municipio de José María Morelos del estado de Quintana Roo. Metodología: enfoque mixto de investigación acerca de 886 productores de miel, para el cual se diseñaron un instrumento de encuesta y entrevistas semiestructuradas que se hicieron a los líderes apiarios de la región. Resultados: el diseño de un centro de articulación productiva de interés para los productores de miel teniendo en cuenta el análisis de la cadena de valor, el estudio de la situación apícola en el municipio, la identificación de la cadena de valor y el desarrollo de la articulación de los actores que en ella intervienen. Valor: se describen las oportunidades de mercado en el ámbito de la apicultura nacional e internacional y se examina la viabilidad de conseguir financiamiento económico. Limitaciones: el estudio se circunscribe a una muestra extraída del municipio de José María Morelos. Conclusiones: existe la voluntad de los líderes apiarios y productores de integrarse a dinámicas que propicien la obtención de beneficios económicos para las comunidades.