bluuebunny/crossref_metadata_2025 huggingface dataset:
Extreme Liquidity Risk and the Cross‐Section of Expected Returns: Evidence from China*
Authors: Hu Zhijun , Sun Ping‐Wen
Published: April 2023

In this study, we investigate whether extreme liquidity risk is priced in the China A‐shares market. We find that the market extreme liquidity risk significantly and negatively predicts market returns up to 9 months. In addition, the extreme liquidity risk beta of individual stocks commands a positive monthly premium of 0.75%. Moreover, our findings show that the extreme liquidity risk beta can subsume the tail risk beta in predicting stock returns. Furthermore, our findings show that both the potential selling pressures caused by insiders and by institutional investors significantly and positively influence an individual stock's extreme liquidity risk beta. We also find that the potential selling pressure component of the extreme liquidity risk beta significantly and positively predicts stock returns. Taken together, our evidence demonstrates that a stock's extreme liquidity risk beta provides a channel through which the stock's potential selling pressure caused by both insiders and institutional investors influences its expected return in the China A‐shares market.
Extracorporeal life support in mitral papillary muscle rupture: Outcome of multicenter study
Authors: Massimi Giulio , Matteucci Matteo , De Bonis Michele , Kowalewski Mariusz , Formica Francesco , Russo Claudio Francesco , Sponga Sandro , Vendramin Igor , Colli Andrea , Falcetta Giosuè , Trumello Cinzia , Carrozzini Massimiliano , Fischlein Theodor , Troise Giovanni , Actis Dato Guglielmo , D'Alessandro Stefano , Nia Peyman Sardari , Lodo Vittoria , Villa Emmanuel , Shah Shabir Hussain , Scrofani Roberto , Binaco Irene , Kalisnik Jurij Matija , Pettinari Matteo , Thielmann Matthias , Meyns Bart , Khouqeer Fareed A. , Fino Carlo , Simon Caterina , Severgnini Paolo , Kowalowka Adam , Deja Marek A. , Ronco Daniele , Lorusso Roberto
Published: April 2023

Background

Post‐acute myocardial infarction papillary muscle rupture (post‐AMI PMR) may present variable clinical scenarios and degree of emergency due to result of cardiogenic shock. Veno‐arterial extracorporeal life support (V‐A ECLS) has been proposed to improve extremely poor pre‐ or postoperative conditions. Information in this respect is scarce.

Methods

From the CAUTION (meChanical complicAtion of acUte myocardial infarcTion: an InternatiOnal multiceNter cohort study) database (16 different Centers, data from 2001 to 2018), we extracted adult patients who were surgically treated for post‐AMI PMR and underwent pre‐ or/and postoperative V‐A ECLS support. The end‐points of this study were in‐hospital survival and ECLS complications.

Results

From a total of 214 post‐AMI PMR patients submitted to surgery, V‐A ECLS was instituted in 23 (11%) patients. The median age was 61.7 years (range 46–81 years). Preoperatively, ECLS was commenced in 10 patients (43.5%), whereas intra/postoperative in the remaining 13. The most common V‐A ECLS indication was post‐cardiotomy shock, followed by preoperative cardiogenic shock and cardiac arrest. The median duration of V‐A ECLS was 4 days. V‐A ECLS complications occurred in more than half of the patients. Overall, in‐hospital mortality was 39.2% (9/23), compared to 22% (42/219) for the non‐ECLS group.

Conclusions

In post‐AMI PMR patients, V‐A ECLS was used in almost 10% of the patients either to promote bridge to surgery or as postoperative support. Further investigations are required to better evaluate a potential for increased use and its effects of V‐A ECLS in such a context based on the still high perioperative mortality.
Are there any differences in the corporate social responsibility strategy of fruit and vegetable production‐commercialization cooperatives and other companies operating in southeastern Spain?
Authors: Martos‐Pedrero Antonio , Belmonte‐Ureña Luis J. , Cortés‐García Francisco Joaquín
Published: April 2023

Customers, civil organizations, the media, and society demand that companies behave in ways beyond regulatory requirements concerning social and environmental issues. Therefore, companies are striving to adapt to these new requirements and to express their commitment to stakeholders through their Corporate Social Responsibility (CSR) strategy. The values and principles of cooperatives make them ideal for responsible business management within the framework of CSR. Almeria is a province in southeastern Spain and it is one of the areas with the highest concentration of agribusiness in Europe. This paper aims to empirically verify whether the CSR orientation of agricultural cooperatives in this province are greater than that of other companies because of the application of these principles. Or, if globalization and competition is pushing these organizations to abandon their principles and values while losing their distinctive identity. A cluster analysis was applied to a representative sample of 107 fruit and vegetable production‐commercialization companies, and this included five dimensions of study applying the stakeholder theory: partners, employees, customers, farmers, and the environment. According to their legal form, we concluded that these entities do not significantly differ in their corporate social responsibility strategy. The Mann‐Whitney nonparametric analysis indicates that only the employee dimension shows significant differences depending on the legal form.
Computational and structural insights into the pre‐ and post‐hydrolysis states of bovine multidrug resistance‐associated protein 1
Authors: Tóth Ágota , Crespi Veronica , Janaszkiewicz Angelika , Di Meo Florent
Published: April 2023

ATP‐binding cassette C‐family drug membrane transporters play an important role in local pharmacokinetics, that is, drug concentration in cellular compartments. From the structural point of view, only the bovine ortholog of the multidrug resistance‐associated protein 1 (bMRP1) has been resolved. We here used μs‐scaled molecular dynamics simulations to investigate the structure and dynamics of the bovine multidrug resistance‐associated protein 1 in pre‐ and post‐hydrolysis functional states. The present work aims to examine the slight but likely relevant structural differences between pre‐ and post‐hydrolysis states of outward‐facing conformations as well as the interactions between the multidrug resistance‐associated protein 1 and the surrounding lipid bilayer. Global conformational dynamics show unfavourable extracellular opening associated with nucleotide‐binding domain dimerization indicating that the post‐hydrolysis state adopts a close‐cleft conformation rather than an outward‐open conformation. Our present simulations also highlight persistent interactions with annular cholesterol molecules and the expected active role of lipid bilayer in the allosteric communication between distant domains of the transporter.
Beans with bugs: Covert carnivory and infested seed selection by the red‐nosed cuxiú monkey
Authors: Barnett Adrian A. , dos Santos‐Barnett Tereza Cristina , Muir Jen , Tománek Pavel , Gregory Tremaine , Matte Ana Luiza L. , Bezerra Bruna M. , de Oliveira Tadeu , Norconk Marilyn , Boyle Sarah A.
Published: April 2023

Members of the Neotropical primate genus Chiropotes eat large volumes of immature seeds. However, such items are often low in available proteins, and digestion of seeds is further inhibited by tannins. This suggests that overall plant‐derived protein intake is relatively low. We examined the presence of insect larvae in partially eaten fruits, compared with intact fruit on trees, and examined fecal pellets for the presence of larvae. We found that red‐nosed cuxiú (Chiropotes albinasus) individuals may supplement their limited seed‐derived protein intake by ingesting seed‐inhabiting insects. Comparison of fruits partially eaten for their seeds with those sampled directly from trees showed that fruits with insect‐containing seeds were positively selected in 20 of the 41 C. albinasus diet items tested, suggesting that fruits with infested seeds are actively selected by foraging animals. We found no differences in accessibility to seeds, that is, no differences in husk penetrability between fruits with infested and uninfested seeds excluding the likelihood that insect‐infestation results in easier access to the seeds in such fruits. Additionally, none of the C. albinasus fecal samples showed any evidence of living pupae or larvae, indicating that infesting larvae are digested. Our findings raise the possibility that these seed‐predating primates might provide net benefits to the plant species they feed on, since they feed from many species of plants and their actions may reduce the populations of seed‐infesting insects.

Abstract in Portuguese is available with online material.
ROCK inhibitors in ophthalmology: A critical review of the existing clinical evidence
Authors: Karri Roshan , Chong Elaine W.
Published: April 2023

Rho kinase (ROCK) inhibitors have emerged as a key therapeutic class of interest in ophthalmology over the last decade. Promising in vitro studies laid the foundations for the development of novel therapeutic agents that target the ROCK signalling pathway in ocular disease, with subsequent clinical trials supporting their use. Corneal endothelial disease, glaucoma, and vitreoretinal disease are the major pathologies in which ROCK inhibitors have been investigated to date. Ripasudil and netarsudil represent the current leaders in this pharmaceutical group, having been extensively validated and approved for use in glaucoma in some countries. Less substantial evidence exists for fasudil in ophthalmic use. ROCK inhibitors are also increasingly used in cultured endothelial cell grafting and as an adjunct to aid in endothelial cell migration and replication in Descemet's stripping procedures or Descemet's membrane injuries. This review has synthesised both established and emerging research to provide a practical guide to prescribing in this drug class. Drug efficacies, side effect profiles, and the demographic and clinical characteristics of appropriate drug candidates are discussed.
Role conflicts of preschool teachers: From children's perspectives in a changing cultural setting in Taiwan
Authors: Su Yuling , Chung Ya‐hui
Published: April 2023

This study investigated children's perspectives on preschool teachers' roles in Taiwan's changing cultural setting. This study attempted to examine how aspects of culture and time are interwoven in children's lives. Data were collected through children's drawings, the photographs they captured and drawing‐photo elicitation interviews. The data were analysed to identify the eight types of teachers' roles and the time points at which the children observed the roles. The children noted that their teachers were ‘regulators’; however, they also discovered teachers' interactive and democratic roles in less structured settings during the time of learning areas and while outdoors.
Factors associated with choice of behavioural weight loss program by adults with obesity
Authors: Jamshidi‐Naeini Yasaman , Roberts Susan B. , Dickinson Stephanie , Owora Arthur , Agley Jon , Zoh Roger S. , Chen Xiwei , Allison David B.
Published: April 2023

We assessed the preference for two behavioural weight loss programs, Diabetes Prevention Program (DPP) and Healthy Weight for Living (HWL) in adults with obesity. A cross‐sectional survey was fielded on the Amazon Mechanical Turk. Eligibility criteria included reporting BMI ≥30 and at least two chronic health conditions. Participants read about the programs, selected their preferred program, and answered follow‐up questions. The estimated probability of choosing either program was not significantly different from .5 (N = 1005, 50.8% DPP and 49.2% HWL, p = .61). Participants' expectations about adherence, weight loss magnitude, and dropout likelihood were associated with their choice (p < .0001). Non‐White participants (p = .040) and those with monthly income greater than $4999 (p = .002) were less likely to choose DPP. Participants who had postgraduate education (p = .007), did not report high serum cholesterol (p = .028), and reported not having tried losing weight before (p = .025) were more likely to choose DPP. Those who chose HWL were marginally more likely to report that being offered two different programs rather than one would likely affect their decision to enrol in one of the two (p = .052). The enrolment into DPP and HWL was balanced, but race, educational attainment, income, previous attempt to lose weight, and serum cholesterol levels had significant associations with the choice of weight loss program.
Impact of donor sex on hepatocellular carcinoma recurrence in liver transplantation after brain death
Authors: Nakamura Tsukasa , Sasaki Kazunari , Kojima Lisa , Teo Richard , Inaba Yosuke , Yamamoto Takayuki , Kimura Shoko , Dageforde Leigh Anne , Yeh Heidi , Elias Nahel , Bozorgzadeh Adel , Kawai Tatsuo , Markmann James F.
Published: April 2023

Background

Hepatocellular carcinoma (HCC) is predominantly seen in males but has a better prognosis in females. No prior studies have investigated HCC recurrence based on sex combination following liver transplant donated after brain death (DBDLT). This study sought to elucidate the effects of donor and recipient sex on HCC recurrence rates.

Methods

9232 adult recipients from the United Network for Organ Sharing (UNOS) database who underwent DBDLT for HCC from 2012 to 2018 were included. Donor‐recipient pairs were divided into (1) female donor/female recipient (F‐F) (n = 1089); (2) male donor/female recipient (M‐F) (n = 975); (3) female donor/male recipient (F‐M) (n = 2691); (4) male donor/male recipient (M‐M) (n = 4477). The primary prognostic outcome was HCC recurrence. A multivariable competing risk regression analysis was used to assess prognostic influences.

Results

The median recipient age and model for end‐stage liver disease (MELD) scores were similar among the four groups. Livers of male recipients demonstrated greater in size and number of HCC (both p‐values were <.0001). There was also a higher rate of vascular invasion in male recipients compared to female (p < .0001). Competing risk analyses showed that the cumulative HCC recurrence rate was significantly lower in the M‐F group (p = .013). After adjusting for tumor characteristics, liver grafts from male donors were associated with a lower HCC recurrence rate in female recipients (HR: .62 95%CI: .42‐.93) (p = .021).

Conclusion

In DBDLT, male donor to female recipient pairing exhibited lower HCC recurrence rates.

Lowest rates of HCC recurrence were confirmed among the female recipients of male donor grafts group in the deceased donor LT cohort. A competing risk multivariable regression analysis demonstrated that male donor sex was significantly associated with low HCC recurrence in female but not male recipients.
Continuous versus intermittent infusion of human antithrombin III concentrate in the immediate postoperative period after liver transplantation
Authors: Kim Bo Rim , Lim Leerang , Choi YoungRok , Yi Nam‐Joon , Lee Kwang‐Woong , Suh Kyung‐Suk , Yu Kyung‐Sang , Sohn Jin Young , Jeong Raewon , Oh Jaeseong , Ryu Ho Geol
Published: April 2023

Antithrombin‐III (AT‐III) concentrates have been used in the immediate postoperative period after liver transplantation to prevent critical thrombosis. We aimed to investigate a more appropriate method for AT‐III concentrate administration to maintain plasma AT‐III activity level within the target range. In this randomized controlled trial, 130 adult patients undergoing living‐donor liver transplantation were randomized to either the intermittent group or continuous group. In the intermittent group, 500 international units (IU) of AT‐III concentrate were administered after liver transplantation and repeated every 6 h for 72 h. In the continuous group, 3000 IU of AT‐III were continuously infused for 71 h after a loading dose of 2000 IU over 1 h. Plasma AT‐III activity level was measured at 12, 24, 48, 72, and 84 h from the first AT‐III administration. The primary outcome was the target (80%–120%) attainment rate at 72 h. Target attainment rates at other timepoints and associated complications were collected as secondary outcomes. A total of 107 patients were included in the analysis. The target attainment rates at 72 h post‐dose were 30% and 62% in the intermittent group and continuous group, respectively (p = 0.003). Compared to the intermittent group, patients in the continuous group reached the target level more rapidly (12 vs. 24 h, median time, p < 0.001) and were more likely to remain in the target range until 84 h. For maintaining the target plasma AT‐III activity level after living‐donor liver transplantation, continuous infusion of AT‐III seemed to be more appropriate compared to the conventional intermittent infusion regimen.
When patients have better insurance coverage in China: Provider incentives, costs, and quality of care
Authors: Luan Mengna , Shi Wenjing , Tao Zhigang , Yuan Hongjie
Published: April 2023

This paper uses a patient discharge dataset from China to study whether and how medical expenses increase for those patients who have better insurance coverage. It uncovers consistent increases in total medical expenses and across each of the three broad categories of expenses (prescription drug expenses, diagnostic test expenses, and other service expenses), no improvement in the quality of care delivered. These increases in expenses can be attributed to patients, physicians, or both. The study provides evidence that physicians' financial incentives play an important role in inducing the increase in medical expenses and that physicians' workload level affects the role of their financial incentives.
Perceptions of emergency department physicians regarding the management of traumatic dental injuries
Authors: Steeves Erin , Doyle Tracy , Mello Isabel
Published: April 2023

Background/Aim

The purpose of this study was to investigate the self‐reported confidence level and education of Atlantic Canada emergency department physicians in the management of traumatic dental injuries and to assess the need for further education surrounding the management of dental trauma.

Material and Methods

An 18‐item survey was developed and distributed electronically to physicians by their respective provincial medical associations.

Results

Traumatic dental injuries were reported in the emergency department on a weekly basis (78%). Most respondents reported that they were somewhat confident (51%) or very confident (7%) in managing traumatic dental injuries. Physicians' years in practice correlated positively with self‐reported confidence levels in managing dental trauma. Urban and rural emergency department physicians reported similar levels of access to general dentists (38% and 30%, respectively); however, urban emergency department physicians reported greater access to pediatric dental specialists (43%) and oral and maxillofacial surgeons (81%) than rural practicing colleagues (4% and 30%, respectively). Most emergency department physicians (85%) agreed that it was important to receive training on the management of traumatic dental injuries and reported that education on managing traumatic dental injuries during residency (37%) and access to a dental trauma decision‐making pathway (30%) would be of most value.

Conclusions

This study highlights the role of emergency department physicians as first responders and demonstrates opportunities for improvement in the initial management of traumatic dental injuries. These implications can be achieved through the incorporation of further training in emergency medicine residency programs and through the implementation of decision‐making pathways in emergency departments.
Promoting Indigenous‐led restoration: The Seed and Nursery Industry Forum for Aboriginal Organisations, Northam, Western Australia, September 2022
Authors: Miller‐Sabbioni Christian , van Leeuwen Stephen , Knight Andrew T. , Dixon Kingsley , Turner Shane , Just Michael , Pedrini Simone
Published: April 2023

Bilya Bilya Koort Boodja Centre for Nyoongar Culture and Environmental Knowledge in Northam, Western Australia, was the location for this event where legislators, practitioners, academics, Nyoongar Elders, and key representatives for Traditional Steward groups gathered to discuss the current issues and future trajectory of the emerging Indigenous nursery sector, specifically the activities of native seed and seedling supply chain. These activities are key components of the emerging Indigenous‐led restoration economy and indispensable for biodiverse restoration of degraded ecosystems at the landscape scale. Key outcomes included: improved awareness in participants about activities being undertaken across the restoration economy sector; the acknowledgement of a disjunction between academia and business practice, and the realisation that bridging the gap between knowledge and action is becoming increasingly urgent.
Chronic inflammatory neuropathies and their impact on activities and participation
Authors: Wonink Henderyke A. , Kruithof Willeke J. , Goedee H. Stephan , Beelen Anita
Published: April 2023

Background

Chronic inflammatory demyelinating polyneuropathy (CIDP) and multifocal motor neuropathy (MMN) are inflammatory neuropathies that can lead to considerable limitations in daily activities and in social participation. However, systematic evaluation of these self‐reported limitations is lacking in the currently available studies. Understanding the impact of these diagnoses on patients' life is important to optimize management strategies.

Aim

To systematically assess the self‐reported limitations in activities and participation and determine associated factors.

Methods

A survey study was conducted in 2021 in a cohort of patients with CIDP (n = 257) and MMN (n = 148) from a university hospital. The survey included the Rasch‐built Overall Disability Scale and the Utrecht Scale for Evaluation of Rehabilitation‐Participation, questions addressing personal and disease‐related factors and treatment. Multivariate linear regression analysis was used to determine associations with disease‐related and personal factors.

Results

A total of 147 CIDP and 103 MMN patients responded. Limitations in activities were reported by 70.7% CIDP and 52.2% MMN patients with moderate to severe limitations in 22.4% and 5.9% patients, respectively. Participation restrictions were reported by 50% of CIDP and 40% of MMN patients, nevertheless satisfaction with participation was high. Fatigue, pain and resilience were independently associated with limitations in activities and satisfaction with participation in CIDP patients.

Conclusions

Activity limitations and restrictions in participation are common in CIDP patients and to a lesser extent in MMN patients. Fatigue, pain and resilience independently contributed to perceived limitations in CIDP patients. Referral to a rehabilitation physician is warranted to address these limitations appropriately.
Review and standard operating procedures for collection of biospecimens and analysis of biomarkers innew onsetrefractory status epilepticus
Authors: Hanin Aurélie , Cespedes Jorge , Pulluru Yashwanth , Gopaul Margaret , Aronica Eleonora , Decampo Danielle , Helbig Ingo , Howe Charles L. , Huttner Anita , Koh Sookyong , Navarro Vincent , Taraschenko Olga , Vezzani Annamaria , Wilson Michael R. , Xian Julie , Gaspard Nicolas , Hirsch Lawrence J.
Published: April 2023

New onset refractory status epilepticus (NORSE), including its subtype with a preceding febrile illness known as febrile infection‐related epilepsy syndrome (FIRES), is one of the most severe forms of status epilepticus. The exact causes of NORSE are currently unknown, and there is so far no disease‐specific therapy. Identifying the underlying pathophysiology and discovering specific biomarkers, whether immunologic, infectious, genetic, or other, may help physicians in the management of patients with NORSE. A broad spectrum of biomarkers has been proposed for status epilepticus patients, some of which were evaluated for patients with NORSE. Nonetheless, none has been validated, due to significant variabilities in study cohorts, collected biospecimens, applied analytical methods, and defined outcome endpoints, and to small sample sizes. The NORSE Institute established an open NORSE/FIRES biorepository for health‐related data and biological samples allowing the collection of biospecimens worldwide, promoting multicenter research and sharing of data and specimens. Here, we suggest standard operating procedures for biospecimen collection and biobanking in this rare condition. We also propose criteria for the appropriate use of previously collected biospecimens. We predict that the widespread use of standardized procedures will reduce heterogeneity, facilitate the future identification of validated biomarkers for NORSE, and provide a better understanding of the pathophysiology and best clinical management for these patients.
Antecedents of intention to use chatbots in service encounters: A meta‐analytic review
Authors: Gopinath Krishnan , Kasilingam Dharun
Published: April 2023

The trend of using artificial intelligence based chatbots for service encounters has seen a significant spike in recent times. Many studies have attempted to explain the adoption of the technology for various service applications; this study synthesizes the literature through a meta‐analysis, for which data from 70 independent studies, with a combined sample size of 20,026 was considered, to understand the influencers of the attitude and intention to use chatbots for service encounters. In addition, this study also sought to understand the moderating role of the culture, the technological characteristics captured through the variables transactional/non‐transactional, and informative/entertaining of the hypothesized relationships. Meta structural equation modelling (meta‐analytic SEM) was used to analyse the data. The results indicate playfulness, attitude, usefulness, facilitating condition and social influence of the chatbots are the key factors in influencing user adoption. Further, technological characteristics and culture were found to significantly moderate certain relationships in the model. Practical and theoretical implications have also been discussed.
Latin American Social Medicine in Colombia: Violence, neoliberalism, and Buen Vivir
Authors: Laurens Vivian , Abadía‐Barrero César , Hernández Mario
Published: April 2023

This article explores the efforts of Latin American Social Medicine (LASM) scholars/activists to incorporate decolonial approaches to support peace building in Colombia. We draw from our participation in Red SaludPaz (RSP); a network of universities and civil society organizations dedicated to supporting the peace accord, and guided by social medicine and the indigenous epistemology of Buen Vivir. We describe the work of RSP both as researchers and as active participants of this network guided by participatory action research in the tradition of Fals Borda. We ask what challenges are faced by RSP when reflecting on Buen Vivir, and how to understand our own endeavor to examine community‐based projects through Buen Vivir. We have found that RSP's commitment to promote peace has invited LASM scholars/activists to decolonize notions of health and wellbeing and to think about Buen Vivir as a pathway to emancipation from the rigid confines of western epistemology.
Investigation of Rhodnius prolixus head anatomy using microtomography
Authors: Sena Gabriela , da Silva Ademir X. , Nogueira L. P. , Colaço M. V. , Mestcher Brian , Fidalgo G. , Pickler A. , Azambuja P. , Gonzalez M. S. , Mattos D. P , Barroso Regina.Cely.
Published: April 2023

In the last years, microtomography has proved to be a powerful technique on insects’ studies, allowing a detailed view of the structures’ internal with a high resolution. One of the most important advantages about the use of microtomography in these studies is the fact that the dissection is not necessary, which decreases considerably the number of samples used on the insects’ research. Some insects are used constantly in studies about morphology, metamorphosis, and reproduction, because they work as a model for others, and Rhodnius prolixus is one of the most studied in this group. This insect is also one of the main insect vectors of Chagas disease that kills around 12,000 people every year in Latin America. Some studies using laboratory microtomography conventional scanners combining with the correct staining methods have proved that it could be a powerful tool in biological research, allowing the visualisation of low‐density tissues. The main goal of the present work was to use staining protocols to study Rhodnius prolixus with laboratory microtomography conventional scanners. The experiments were carried out at the imaging lab in the Theoretical Biology Department, University of Vienna, using an Xradia MicroXCT and at the University of Oslo, using a Skyscan 2211.
Blood group in relation to oral Fordyce's granules and serum cholesterol level
Authors: Diajil Ameena Ryhan , Goodson Michaela Louise
Published: April 2023

Background

The ABO and Rh systems are the most commonly used blood‐group systems used to classify blood group globally. A number of studies have shown that ABO blood groups may be associated with an increased serum cholesterol levels which in turn may be related to the presence of oral Fordyce spots or granules. Oral Fordyce's granules are ectopic sebaceous glands within the oral cavity and are visible through epithelium. The aim of this study was to assess the relationship between ABO and Rhesus blood groups and the presence of oral Fordyce's granules and serum cholesterols level by gender.

Methods

Following ethical approval and informed consent, 124 subjects were recruited into this cross‐sectional study. Clinical oral examination assessed the number of Fordyce's granules and blood samples were collected to determine the serum cholesterol and ABO/Rh blood‐group systems of individual subjects.

Results

Blood group AB+showed the highest mean of oral Fordyce's granules number and serum cholesterol level but this was not statistically significant compared to other blood groups. Female subjects in this study who were AB+were had significantly higher serum cholesterol levels than males.

Conclusion

This study indicates an association between ABO blood group, serum cholesterol level and mean number of oral Fordyce's granules. A larger sample size in a future study is required to ascertain whether number of Fordyce's granules is an important measure of serum cholesterol, but the study does show that for AB+individuals, females may have higher serum cholesterol than males.
Frequency domain identification of modal characteristics and loads from output‐only measurements
Authors: Hwang Jae‐Seung , Kwon Dae Kun , Kareem Ahsan
Published: April 2023

This paper proposes a frequency domain framework for concurrently estimating the modal structural parameters and modal loads from the measured output response. A mathematical load model is theoretically developed and compared to the load determined by force identification. Unlike conventional modal identification schemes, the proposed approach can effectively accommodate the spectral shape of the external load in the frequency domain, enabling the determination of the modal parameters without explicit white noise assumption. The proposed approach is verified by applying it to a single‐degree‐of‐freedom system system representing a modal response, an aeroelastic model in an atmospheric boundary layer wind tunnel, a multi‐degree‐of‐freedom system, and the measured acceleration response of a 40‐story building. The simulation results demonstrate that the proposed technique can reliably estimate the modal parameters and load model and is robust against the noise present in the response and the order of the load model. Additionally, the proposed technique can be applied to various loading conditions such as vortex‐induced and buffeting effects since the modal parameters and the load model can be identified for any shape of the loading spectrum.
Heteroskedasticity‐Robust Standard Errors for Dynamic Panel Data Models with Fixed Effects*
Authors: Han Chirok , Kim Hyoungjong
Published: April 2023

For linear panel data models with fixed effects, cluster‐robust covariance estimation does not use variability over time. The extant heteroskedasticity‐robust methods available under strict exogeneity do not generalize to dynamic models. We propose novel robust covariance estimators under a strong version of serial uncorrelatedness, where serial uncorrelatedness is required to identify dynamic panel models. Asymptotics are established, and simulations verify theoretical findings. The estimator can apply to the popular dynamic IV‐GMM estimators and be a sharper alternative for cluster‐robust covariance estimators in panel data models with limited cross‐sectional information.
Comparison of visual performance between peripheral gradient high‐addition multifocal soft contact lenses and orthokeratology
Authors: Chen Yunyun , Ding Chenglu , Li Xue , Huang Yingying , Zhou Fengchao , Drobe Björn , Chen Hao , Bao Jinhua
Published: April 2023

Purpose

The aim of this study was to evaluate the short‐term effects of peripheral gradient high‐addition multifocal soft contact lenses (MFSCLs) and orthokeratology (Ortho‐K lenses) on visual performance in myopic children.

Methods

Thirty myopic children participated in this prospective study. Each participant wore different sets of lenses in the following sequence: single‐vision spectacles (SVSPs) as a control, MFSCLs and Ortho‐K lenses. Ocular aberrations, topography, high‐contrast visual acuity (HCVA), low‐contrast visual acuity (LCVA) and accommodation of the right eye were measured with each type of correction on a different day.

Results

Compared with SVSPs, high‐addition MFSCLs and Ortho‐K lenses significantly increased all items of aberrations (all p < 0.05) except trefoil (p = 0.17). MFSCLs induced less coma, root mean square of the third‐order aberration (RMS3) and higher order aberrations than Ortho‐K lenses (all p < 0.05). No significant difference in HCVA was found across the three correction types (F = 1.19, p = 0.39). In terms of LCVA, MFSCLs performed significantly poorer than SVSPs (difference, 0.16 logMAR; p = 0.001) and slightly worse than Ortho‐K lenses (difference, 0.08 logMAR; p = 0.35). No significant difference in decentration was found between the two types of contact lenses, and no associations were observed between decentration and visual acuity at both high‐ and low‐contrast levels (all p > 0.05). For MFSCLs, decentration was positively related to coma (r = 0.43, p = 0.02) and RMS3 (r = 0.44, p = 0.02), which was not the case for Ortho‐K lenses. Accommodative facility was worse with MFSCLs than Ortho‐K lenses (p = 0.001).

Conclusion

Multifocal soft contact lenses differed from Ortho‐K lenses in aberration profile and LCVA, although decentration was similar. Decentration <1 mm had minimal influence on both HCVA and LCVA for either type of correction, but significantly increased third‐order aberrations for MFSCLs, but not Ortho‐K lenses.
Beyond the 5‐year milestone: Long‐term survivorship of melanoma patients treated off‐trial with anti‐PD‐1
Authors: Loo Kimberly , Kalvin Hannah L. , Panageas Katherine S. , Callahan Margaret K. , Chapman Paul B. , Momtaz Parisa , Shoushtari Alexander N. , Wolchok Jedd D. , Postow Michael A. , Warner Allison Betof
Published: April 2023

Little is known about the long‐term outcomes of anti‐PD‐1 treated patients with melanoma beyond 5 years, especially for patients treated off clinical trials. This retrospective cohort study includes patients with unresectable stage III/IV nonuveal melanoma treated with anti‐PD‐1 off‐trial at Memorial Sloan Kettering Cancer Center between 2014 and 2017 who survived at least 5 years following their first anti‐PD‐1 dose (N = 139). We characterized overall survival (OS), melanoma‐specific survival (MSS) estimates, treatment‐free survival rates, and subsequent treatment courses. Median follow‐up among 5‐plus year survivors (N = 125) was 78.4 months (range 60.0–96.3). OS at year 7 (2 years post 5‐year landmark) was 90.1% (95% CI: 83.0%–94.3%). Fourteen deaths occurred, seven due to melanoma. MSS at year 7 (2 years post 5‐year landmark) was 95.0% (95% CI: 33.5%–95.2%). In patients who completed anti‐PD‐1 based therapy and did not require subsequent treatment by 5 years (N = 80), the probability of not requiring additional treatment for an additional 2 years was 95.7% (95% CI: 91.0%–100%). Patients treated with anti‐PD‐1 regimens off clinical trials who survive at least 5 years from initial anti‐PD‐1 treatment can be reassured of their excellent long‐term prognosis, particularly if they did not require additional melanoma treatment during the first 5 years.
Bioeconomic modelling in tilapia aquaculture: A review
Authors: Dorantes‐de‐la‐O Juan Carlos R. , Maeda‐Martínez Alfonso N. , Espinosa‐Chaurand Luis D. , Garza‐Torres Rodolfo
Published: April 2023

The global production of aquatic resources is increasing at the rate of 3.3 million tons per year, main thanks to aquaculture. However, this industry is considered by financial institutions as high risk due to failures caused by epizootics, natural disasters and poor planning and monitoring. Bioeconomic modelling is a progressive branch of social science that seeks to integrate the disciplines of economics and biology to create theories that better explain economic events using a biological basis and vice versa. This should be used in aquaculture to plan, monitor, and determine cost‐effectiveness and risk, to reduce uncertainty and increase profits of ongoing or new projects. A meta‐analysis of the literature on bioeconomic modelling in aquaculture during 26 years (1994─2020) was performed, using four search engines. Sixty‐eight articles were published in 23 journals, on 25 groups of species or species. The most studied were shrimp, tilapia, seabream, salmon and carp. From these, 12 articles dealt with tilapia models that shared similar biological, management and economic sub‐models. In the 26‐year analysis, the global scientific productivity in this field is low (2.6 articles/year) in relation to the growth of world aquaculture. Bioeconomic modelling peaked during the decade from 2004 to 2014 with 5.6 papers/year, but then declined to only 0.83 articles/year from 2015 to 2020. This is possibly due to the low diffusion among producers, planners and financial institutions of the advantages of the models and the difficulty to use them if friendly and readily available software is lacking.
Encounters with the Pre‐Nicene ChristLearning Christ: Ignatius of Antioch and The Mystery of Redemption, GregoryVall, The Catholic University of America Press, 2021 (ISBN 978‐0‐8132‐3478‐6), xiv + 402 pp., pb $34.95Clement and Scriptural Exegesis: The Making of a Commentarial Theologian, H.Clifton Ward, Oxford University Press, 2022 (ISBN 978‐0‐19‐286336‐2), xiv + 240 pp., hb £90Cross and Creation: A Theological Introduction to Origen of Alexandria, Mark E.Therrien, The Catholic University of America Press, 2022 (ISBN 978‐0‐8132‐3530‐1), xxiv + 304 pp., pb $34.99Origen and the Emergence of Divine Simplicity Before Nicaea, PuiHim Ip, University of Notre Dame Press, 2022 (ISBN 978‐0‐268‐20361‐0), xx + 276 pp., hb $85
Authors: O'Leary Joseph S.
Published: April 2023

These four books, all exemplary, attest the vibrancy of patristic scholarship today, and especially the fascination which the pre‐Nicene period increasingly exerts. Stepping back behind Nicaea demands a refined sense for the texture of history, which may bring to light possibilities later lost as well as tensions later smothered. The four authors have illuminated afresh the theological profiles of Ignatius, Clement, and Origen, and also the figure of Christ as it emerges in these pristine centuries between the New Testament and Nicaea.
Imitating God and Familiar Identity: An Exploration in Developmental Psychology, Theology, and Ecclesial IdentityMarried Priests in the Catholic Church, Adam A. J.Deville (ed.), University of Notre Dame Press, 2021 (ISBN 978‐0‐268‐20010‐7), XXVI + 350 pp., pb $35Made in the Image of God: Being Human in the Christian Tradition, MichaelFuller, and DavidJasper (eds), Sacristy Press, 2021 (ISBN 978‐1‐78959‐170‐5), x + 282 pp., pb £24.99Forming Resilient Children: The Role of Spiritual Formation for Healthy Development, Holly CattertonAllen, IVP, 2021 (ISBN 978‐1‐5140‐0172‐1), x + 190 pp., pb $24
Authors: Farris Joshua R.
Published: April 2023

The nature of familial identity is central to a growing number of theological works. The authors of the volumes here each represent a different set of issues, disciplines, and perspectives. The discussions, ironically, center around family. Made in the Image of God gives the readers a series of reflections on diverse theological topics oscillating around the image and identity. Forming Resilient Children is unlike Made in the Image of God in that it is not strictly speaking a theological reflection on diverse issues, but a work of developmental psychology focusing on the nature of the child and the familial context for the child. Married Priests in the Catholic Church offers the reader a series of ecclesial engagements on the topic of the vocation of priesthood as either married or celibate. Overlapping with the previous two volumes in content by touching on identity, the image of God, and the nature of creaturely relations to God, Married Priests is, in one sense, a sustained reflection on the meaning of familial and organic identity (as an image of God) to the Church.
Characterization of the novel HLA‐C*08:232 allele by next‐generation sequencing
Authors: He Yizhen , Dong Lina , Li Ying , Zhang Wei , Zhu Faming
Published: April 2023

HLA‐C*08:232 differs from HLA‐C*08:01:01:01 by a single nucleotide substitution at position 629 A > G.
Integrating the entrepreneurial mindset into solar energy statistical analysis and performance modeling
Authors: Bosman Lisa , Soto Esteban , Varela Thaís Ferraz , Wollega Ebisa
Published: April 2023

Statistical knowledge is required for students in a range of disciplines. However, there are limited educator resources that exist for applying statistics to solve real‐world problems. This investigation provides one approach to teaching statistics using entrepreneurial‐minded learning (as a way to connect real‐world applications and value creation with problem‐solving and curiosity) in the context of solar energy. Both the ready‐to‐use teaching intervention and assessment of student learning details are provided for an undergraduate course on Introductory Statistics. The teaching intervention includes a series of seven lesson plans (and three extension projects) that educators can use in an introductory statistics course.
HLA antibodies in fetal and neonatal alloimmune thrombocytopenia
Authors: Colvin Zachary A. , Schiller Jennifer , Tsaih Shirng‐Wern , Sharma Ruchika , Grace Rachael F. , McIntosh Jennifer J. , Curtis Brian R.
Published: April 2023

Background

Fetal and neonatal alloimmune thrombocytopenia (FNAIT) is caused by antibodies against human platelet antigens (HPA). However, in many cases that meet clinical criteria for the condition, maternal sera do not have HPA antibodies. In studies examining whether human leukocyte antigen (HLA) antibodies cause FNAIT, the results are limited and inconclusive. This study sought to examine whether clinically suspected FNAIT cases with absent maternal HPA antibodies had different HLA antibody strength and specificity compared to controls.

Study Design and Methods

A retrospective case–control study assessed class I HLA antibody strength and specificity in cases submitted for testing to Versiti, Wisconsin. There were 813 cases that met initial screening criteria, but written consent could only be obtained for 50. After review of medical records and expert panel review, 31 cases with clinical criteria of FNAIT and maternal HLA but not HPA antibodies were included. Each case was matched for maternal age, gestational age at delivery, parity, and race/ethnicity to two controls from unaffected pregnancies that had maternal serum HLA antibodies.

Results

FNAIT cases were found to have both significantly higher HLA antibody strength, measured by mean fluorescence index (MFI), and broader HLA antibody specificity at antigen epitope level, compared to matched controls (p < .001). p‐values remained significant after controlling for parity and gestational age at delivery.

Discussion

Additional studies are needed to further examine whether the strong HLA antibodies identified in HPA‐antibody‐negative cases directly cause neonatal thrombocytopenia and whether prenatal treatment may be warranted in select cases to prevent recurrence.
On the error term in a mixed moment of L‐functions
Authors: Khan Rizwanur , Zhang Zeyuan
Published: April 2023

There has recently been some interest in optimizing the error term in the asymptotic for the fourth moment of Dirichlet L‐functions and a closely related mixed moment of L‐functions involving automorphic L‐functions twisted by Dirichlet characters. We obtain an improvement for the error term of the latter.
La literatura obstinada: la novela en Juan José Saer, Ricardo Piglia y Roberto Bolaño
Authors: Torres Perdigón Andrea
Published: April 2023

Durante los siglos XVIII y XIX surgió una idea particular de la literatura que coincidió con el nacimiento del género novelístico moderno, lo que marcó tanto la teoría literaria del siglo XX como la producción de textos literarios. Este libro presenta un estudio comparativo de las poéticas de Juan José Saer, Ricardo Piglia y Roberto Bolaño con el fin de cuestionar, desde un punto de vista teórico, la vitalidad de esta idea de novela moderna y, por lo tanto, de la noción misma de literatura que esta supone.
Hydrodynamic Coefficients of Generic Subsea Modules in Forced Oscillation Tests—Importance of Structural Elements
Authors: Prsic Mia Abrahamsen , Solaas Frøydis , Kristiansen Trygve
Published: April 2023

A systematic study of hydrodynamic coefficients for simplified subsea modules has been performed to support the estimation of the coefficients needed for planning of subsea installation operations. The coefficients are assessed for a nearly two-dimensional test setup. The tests are performed as forced oscillations at various amplitudes and periods, representing the forces on the module lowered through the water column. The importance of each of the main components of the subsea modules—mudmat, protection roof, and process equipment of different shapes inside the modules are studied in fully submerged condition. Results for the module elements, generic contents, and different combinations of these elements are presented. For the tested modules, damping is generally the dominating hydrodynamic force. However, the presence of the content inside the modules will generally increase the importance of added mass. Estimation of the hydrodynamic coefficients by summation of the coefficients for the individual structure elements generally overestimates the damping, compared to the coefficients measured for the complete modules. For added mass, estimation based on summation gives generally good results.