bluuebunny/crossref_metadata_2025 huggingface dataset:
PEMILIHAN ANALGESIK EKSTERNAL UNTUK MENGATASI NYERI OTOT PADA KULI ANGKUT PUSAT GROSIR SURABAYA
Authors: Sukma Nida Septioning , Cahyani Devy Maulidya , Revi Yuniar Tri Saskia , Febiany Evelyn Clarissa , Alifiyah Fatihatul , Hariawan Berlian Sarasitha , Khosyyatillah Iffah , Khoiriyyah Ni’matul , Ayuningtyas Savira Putri , Rosyidah Firda , Mufarrihah Mufarrihah
Published: September 2020

Di Indonesia rata-rata buruh mengalami nyeri otot dan menggunakan analgesik eksternal untuk menangani nyeri otot. Tujuan dari penelitian ini adalah mengetahui bagaimana penanganan nyeri otot dan apa saja yang memengaruhi pemilihan analgesik eksternal oleh kuli angkut di Pusat Grosir Surabaya (PGS), pengetahuan tentang analgesik eksternal serta peran apoteker dalam pelaksanaan swamedikasi terkait pemilihan analgesik eksternal. Rancangan penelitian yang digunakan adalah cross-sectional. Sampel pada penelitian ini adalah kuli angkut PGS. Data disajikan secara deskriptif dalam bentuk grafik dan tabel berdasarkan jawaban responden pada kuesioner. Total responden berjumlah 100 orang. Mayoritas responden pernah merasakan nyeri di bahu kanan (36) 9,8%. Waktu terjadinya nyeri adalah setelah melakukan aktivitas (84) 82,3% dengan intensitas nyeri sedang (55) 55% dan usaha untuk mengatasi nyeri paling banyak menggunakan obat luar (72) 41,1% jenis obat oles (63) 51,2% dengan efek panas yang diharapkan (80) 74,8%. Alasan dari pemilihan analgesik eksternal adalah khasiat yang ditimbulkan (76) 60,3%. Peran apoteker dalam edukasi analgesik ekstenal masih minim dilihat dari (44) 44% responden memiliki pengetahuan yang kurang mengenai nyeri dan penggunaan analgesik eksternal. Responden banyak memperoleh obat dari toko atau warung (57) 51,8%, apabila nyeri berlanjut kebanyakan responden memilih untuk pergi ke dokter (43) 38,7%.
In vitro Antimicrobial Potency of Lemon Fruit (Citrus limon) Extract on Salmonella typhi
Authors: Rahman Farhan Haidar Fazlur , Alimsardjono Lindawati , Zakaria Sunarni
Published: September 2020

Introduction: This study aimed to evaluate minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of lemon fruit (Citrus limon) extract in inhibiting Salmonella typhi growth in vitro.Methods: This research was categorized as a laboratory experimental study. Lemon fruit (Citrus limon) extract was prepared with concentration as follows: 100.000 ppm, 50.000 ppm, 25.000 ppm, 12.500 ppm, 6.250 ppm, 3.125 ppm, 1.562 ppm, 781 ppm, and 390 ppm. Dilution tests with Mueller-Hinton broth medium were performed to determine the MIC. After 24 hours of incubation, isolated Salmonella typhi inside the tube was inoculated back in MacConkey agar plate medium to determine the MBC. Replications were conducted 3 times according to Federer’s formula.Results: MIC of lemon fruit (Citrus limon) extract to Salmonella typhi was determined at 3.125 ppm. Meanwhile, MBC was determined at 6.250 ppm.Conclusion: This study showed the potential antimicrobial effect of lemon fruit (Citrus limon) extract against Salmonella typhi in-vitro. Further studies are still needed to determine its efficacy and safety in vivo and also its full antibacterial spectrum.
Trafficking of women and girls in the District of Seke: Lessons from the Zimbabwe’s Second Republic
Authors: Zengenene Maybe
Published: September 2020

The study explores the phenomenon of human trafficking in Zimbabwe’s second republic under President Emerson Mnangagwa. Using conflict theory, the study argues that the discourse of human trafficking in Zimbabwe is a complex phenomenon that has led to women’s and girls’ vulnerability in the Seke District. Primary data gathered from five female core informants who have been the direct victims of human trafficking and three significant others who were the parents and guardians of human trafficking victims. The snowball sampling technique was employed to obtain the female core informants for the in-depth interviews. The study also benefitted from secondary sources such as journal articles, online newspapers, government, and international UN, ILO, UNESCO, and UNICEF reports. The results of this study show that eco-socio and political ills such as a high rate of unemployment, a shortage of essential goods, cash, corruption, electricity, gender inequality, poverty, power relations and the continuous harassment by the security forces such as the police and the army have escalated the vulnerability of women to human trafficking in Zimbabwe. Since Zimbabwe’s eco-political situation is a powerful determinant of both the continuation and abandonment of the human trafficking social phenomena, this study recommends that the present government solve the grassroots causes of the phenomena. With enforcement at the grassroots level and regional and international initiatives, human trafficking can be combated.
The function of the educational value in the ma’parapa (silence) text in the process of the rampanan kapa’ (wedding ceremony)
Authors: Sari Harmita , Hasbi Andi Rizkiyah , Palangngan Sukmawati Tono
Published: September 2020

One community that has a complex marriage system is Toraja, it is one of the tribes in Indonesia who still maintains their ancestral cultural traditions in their social life. The institutions in the Toraja communities are always associated with aluk (teachings or rules of life). This study aims to describe the educational values and functions in the text ma’parapa (silence) in the procession of rampanan kapa’ (wedding ceremony) in Tana Toraja. This type of research is qualitative research, and the research data is in the form of text quotations that describe the educational value contained in the ma’parapa text in the procession of the rampanan kapa’ in Tana Toraja. The results of this study indicate that the educational value contained in the text ma’parapa in the procession of rampanan kapa’ consists of 1) the value of religious education, namely to educate all people always to be grateful, to trust, and to exalt God’s power, 2) moral education, namely to express respect or in the sense of asking for permission before doing something in front of others by saying the word tabe, 3) social education, which is useful for the community to foster life with its environment, 4) cultural education, namely inviting all people to always maintain and develop marriage customs in it there are procedures for getting married which contain many moral messages that need to be applied in everyday life. The educational function of the ma’parapa text in the procession of rampanan kapa’ in Tana Toraja includes 1) the function of education for family and cultural groups, which is to encourage the younger generation to dare to speak in public, to be able to implement good behavior in daily life -day, and so that the younger generation can interpret advice, and relationships with God Almighty, and 2) to understand aluk rampanan kapa’ as a very sacred level of the ceremony where if there is a violation it will be sanctioned by fellow humans and also from the Creator.
Characteristics of a flow of documents about novosibirians’ contribution to the Great Patriotic war victory (on the database "Scientific Sibirika")
Authors: Rykova V. V.
Published: September 2020

The article objective is to represent the analysis results of the flow of published documents that highlight the contribution of Novosibirsk city and Novosibirsk Region residents to the victory over fascism during the Great Patriotic war. The documentary flow consisted of more than 600 publications over a 30-year period, which was selected of the regional bibliographic database “Scientific Sibirika” generated by the State Public Scientific and Technological Library of the Siberian Branch of the Russian Academy of Sciences using analytical services. The paper presents a brief scientometric analysis of a document corpus, as well as features of its temporal, thematic, and type-specific structure. Emphasis is placed on the characteristics of monographic publications: their variety is shown, and monograph bibliographic descriptions are given. The article lists the most productive periodicals and thematic collections on the topic, scientific events, where discussions took place on the life of the Siberian region and its inhabitants during the war years. It names Novosiberians – participants of military operations, materials about whom are included into the database. Authors with high publication activity on the above-mentioned subjects are identified. It is concluded that the thematic section “History of Siberia and the Far East” of the database “Scientific Sibirika” serves as a reliable source base for historical and regional studies. Introducing modern technologies in the bibliographic practice makes it possible to work remotely not only with bibliographic descriptions, but with full texts of electronic documents as well.
Note on the Conformable Boundary Value Problems: Sturm’s Theorems and Green’s Function
Authors: Martínez F. , Martínez Inmaculada , Kaabar Mohammed K. A. , Paredes Silvestre
Published: September 2020

Recently, the conformable derivative and its properties have been introduced. In this paper, we propose and prove some new results on conformable Boundary Value Problems. First, we introduce a conformable version of classical Sturm´s separation, and comparison theorems. For a conformable Sturm-Liouville problem, Green's function is constructed, and its properties are also studied. In addition, we propose the applicability of the Green´s Function in solving conformable inhomogeneous linear differential equations with homogeneous boundary conditions, whose associated homogeneous boundary value problem has only trivial solution. Finally, we prove the generalized Hyers-Ulam stability of the conformable inhomogeneous boundary value problem.
Prakonsentrasi Ion Cd(II) dalam Sampel Pupuk Nitrogen, Fosfor dan Kalium (NPK) Menggunakan Alumina Teraktivasi sebagai Material Pengisi Kolom
Authors: Simanjuntak Lossi Hotmaida , Erwin Erwin , Panggabean Aman Sentosa
Published: September 2020

ABSTRAK. Prakonsentrasi ion Cd(II) dalam sampel pupuk nitrogen, fosfor dan kalium (NPK) menggunakan alumina teraktivasi sebagai material pengisi kolom telah dilakukan. Alumina terlebih dahulu diaktivasi dengan NaOH pada pH 8 sebelum dimasukkan ke dalam kolom. Beberapa parameter penting dalam tahapan prakonsentrasi yang dapat meningkatkan kinerja analitik pengukuran telah ditentukan menggunakan instrumen spektrofotometer serapan atom (SSA). Hasil penelitian menunjukkan kondisi optimum tahapan prakonsentrasi ion Cd(II), adalah pada volume sampel 10 mL, volume HNO3 adalah 4 mL pada konsentrasi 0,5 M, dengan nilai kapasitas retensi adalah 1,4113 mg Cd(II)/g alumina. Kinerja analitik pengukuran metode sangat baik, ditunjukkan dengan nilai batas deteksi metode adalah 2,7997 μg/L. Presisi metode dinyatakan sebagai persentase koefisien variansi adalah 4,03%. Penggunaan alumina sebagai bahan pengisi kolom dapat meningkatkan signal sebesar 2,5 kali dibandingkan dengan pengukuran ion Cd(II) secara langsung. Akurasi metode ini sangat baik, dengan nilai persen perolehan kembali adalah 91,67 – 103,49%, menunjukkan bahwa matriks sampel tidak  mempengaruhi hasil pengukuran, sehingga metode ini dapat digunakan untuk analisis ion Cd(II) dalam sampel pupuk NPK. Estimasi ketidakpastian metode ini juga telah dihitung dan ditunjukkan dengan nilai persen ketidakpastian adalah 14,16%.

ABSTRACT. Preconcentration of Cd(II) Ion in Nitrogen, Phosphor, and Kalium (NPK) Fertilizer Sample Using Activated Alumina as a Column Filler Material. The research about preconcentration of Cd(II) in NPK fertilizer using activated alumina as a column filler material was done. The column used a filler material of alumina previously activated using NaOH at pH 8. Some important parameters in the preconcentration stage are able to increase the analytical performance, determined using atomic absorption spectrophotometer (AAS). The result of the research shows the optimum condition of preconcentration stage Cd(II) ion are volume of the sample was 10 mL, the volume of eluent HNO3 was 4 mL with a concentration of 0.5 M, with the retention of capacity value was 1.4113 mg Cd(II)/g alumina. The analytical performance of this method is good, shown with the limit of detection value was 2.7997 μg/L. The precision of this method was indicated by the percentage of the coefficient variance of 4.03%. Alumina used as a filler column can increase the signal up to 2.5 times for direct Cd(II) ions measurement. The accuracy of this method is excellent, with the recovery percentage value was 91.67 – 103.49%, indicating that the matrices of NPK fertilizer give no effect on the results of measurements, and this method was capable of analyzing Cd(II) ions in NPK fertilizer. The uncertainty of this method was estimated as the percentage of the uncertainty of 14.16%.
Decolorization of Methylene Blue Dye Using ZnO/ZSM-5 Photocatalyst Under UV-LED Irradiation
Authors: Astuti Lely Dwi , Kusumawati Yuly , Prasetyoko Didik , Widayatno Wahyu Bambang , Hamid Abdul
Published: September 2020

ABSTRACT. The present research studied about decolorization of methylene blue dye using photocatalyst ZnO/ZSM-5 under UV-LED lamp. ZnO/ZSM-5 was synthesized using the impregnation method by adding two grams ZSM-5 to Zn solution 0.3 M 10 mL. Photocatalyst was characterized using X-ray diffractometer (XRD), Fourier transform infrared (FTIR), field emission scanning electron microscopy-energy dispersive X-Ray (FESEM-EDX), and surface area analyzer (SAA). Analysis using XRD show addition characteristic peaks of ZnO at 2θ 31.60°, 34.21°, 36.08°, 47.35°, 56.50°, 62.73°, 67.83°, that indicates a successful impregnation process. The photocatalysis activity test was done on methylene blue dye 100 mg L-1. ZSM-5 and ZnO activities were tested under UV-LED irradiation and dark conditions. Data showed that percent removal of dye occurred on ZnO/ZSM-5 under 15 minutes irradiation is 78.32%.
Penerapan Metode SVM dan BPNN dalam Pengklasifikasian PUS di Jawa Barat
Authors: Istiqomatul Fajriyah Yuliati  , Septie Wulandary  , Sihombing Pardomuan
Published: September 2020

Penggunaan kontrasepsi menjadi sangat vital bagi pengendalian jumlah penduduk terutama di Jawa Barat karena jumlah penduduk di Provinsi Jawa Barat tertinggi di Indonesia. Klasifikasi penggunaan kontrasepsi pada pasangan usia subur (PUS) berdasarkan faktor determinan penggunaan kontrasepsi di Provinsi Jawa Barat merupakan hal yang menarik untuk dikaji. Penelitian ini mengkaji perbandingan metode Support Vector Machine (SVM) dengan fungsi kernel dan Neural Network  (NN) dengan algoritma backpropagation (BPNN) dalam pengklasifikasian PUS berdasarkan penggunaan kontrasepsi (mengikuti program Keluaga Berencana/KB atau tidak) di Provinsi Jawa Barat. Metode yang memiliki nilai ketepatan yang tinggi merupakan metode terbaik dalam pengklasifikasian PUS berdasarkan penggunaan kontrasepsi. Kedua metode klasifikasi baik BPNN dan SVM Fungsi Kernel dapat menggambarkan klasifikasi PUS berdasarkan determinan penggunaan kontrasepsi di Provinsi Jawa Barat dengan tingkat akurasi yang sama, yaitu sebesar 99.84%.  Hal ini berarti kedua model klasifikasi sangat baik dalam memprediksi kelas yang mengikuti program keluarga berencana atau tidak mengikuti program tersebut.
Ponte Osteotomy in Pediatric Spine Surgery
Authors: Gottlich Caleb , Sponseller Paul D.
Published: September 2020

First utilized in spine surgery in the late 1980s, the Ponte osteotomy is a method of surgically shortening the posterior column in order to obtain greater corrective power in the management of kyphosis or kyphoscoliosis. It is accomplished by removal of bone around the articulation of spinal facet joints, which alters the mechanical axis of rotation and enables greater deformity correction potential. This procedure is performed in the following steps: (1) a posterior midline incision is made in order to expose and clear soft tissues from the desired surgical site; (2) the spinous process and base of the lamina are removed to allow for better visualization and working space; (3) the inferior facet is excised, followed by (4) removal of the superior facet and the (5) ligamentum flavum. If performed correctly, this procedure should allow for appropriate deformity correction and the ability to place desired instrumentation without problems.
Arthroscopic Superior Capsular Reconstruction for Treatment of Massive Irreparable Rotator Cuff Tears
Authors: Adams Christopher R. , Frank Rachel M. , Denard Patrick J. , Millett Peter J. , Hartzler Robert U. , Romeo Anthony A.
Published: September 2020

The treatment of massive, irreparable rotator cuff tears presents a substantial challenge to health-care professionals. Treatment options range from nonoperative to operative, including debridement, partial repair, biceps tenotomy, bridging patch grafts, muscle transfers, and reverse total shoulder arthroplasty. However, the results of such treatments are often mixed, and many carry a substantial risk of complications. Superior capsular reconstruction has been described as a surgical alternative to the aforementioned procedures. Superior capsular reconstruction is a technique that provides an anatomic reconstruction of the superior capsule of the glenohumeral joint, with the goal of restoring the normal restraint to superior translation that is lost with a deficient superior rotator cuff. The technique described in the present article highlights the pearls and pitfalls learned over the last several years of performing arthroscopic reconstruction of the superior capsule with dermal allograft.
The role of knowledge, risk perceptions and cues to action among Iranian women concerning cervical cancer and screening: A qualitative exploration
Authors: Asl Rahim Taghizadeh , Osch Liesbeth Van , De Vries Nanne , Zendehdel Kazem , Shams Mohsen , Zarei Fatemeh , De Vries Hein
Published: September 2020

Background: Iran has a low incidence of, but a higher rate of death from, cervical cancer (CC). The country is in the process of implementing an organized screening program including HPV testing and cytology. Studies show high drop-out in continued testing among eligible women. This qualitative study aimed to explore women’s awareness regarding CC and CC testing, and the role of knowledge, perceived risk, and cues to action in this process. Methods: In a qualitative study based on the Framework Method we recruited 81 women aged between 25-65 years, who participated in 15 focus group discussions (FGDs) and two in-depth interviews in Tehran, the capital of Iran. Interviewees were selected purposefully from households in different socioeconomic classes until data saturation, during January to May 2015. Data were acquired through 11 open-ended questions and 32 related probe questions. All interviews were transcribed and independently analyzed by two researchers (Kappa and agreement testing respectively: 0.77, 97.11%).Results: Coded texts were categorized under three themes and 13 subthemes. The three thematic areas referred to knowledge, cues to action and perceived risks regarding cervical cancer and screening. Results showed that women had limited and unspecified knowledge about cervical cancer and screening, compounded by misconceptions regarding infection and cancer prevention measures. Social and cultural barriers hindered proper communication between health system/providers and clients, and within communities on subjects related to cervical cancer and screening. Perceived risk of getting CC was low because of overestimating the role of hereditary factors for CC, difficulty in differentiating between cancer and sexually transmitted infections, and the absence of visible symptoms.Conclusions: The results indicate a strong need to invest more efforts to improve health education and communication in the current national health program to promote awareness of the need to screen for CC, through, for example, establishing correct knowledge and risk perceptions among women. In addition, this intervention should address women’s social environment in order to prevent misconceptions being communicated to women.
Shared decision-making in advance care planning for persons with dementia in nursing homes: a cross-sectional study.
Authors: Goossens Bart , Sevenants Aline , Declercq Anja , Audenhove Chantal Van
Published: September 2020

Background: Shared decision-making provides an approach to discuss advance care planning in a participative and informed manner, embodying the principles of person-centered care. A number of guided approaches to achieve shared decision-making already exist, such as the three-talk model. However, it is uncertain whether daily practice methods in nursing home wards for persons with dementia comply with the underpinnings of this model. It is also uncertain whether professionals consider shared decision-making to be important in this context, and whether they perceive themselves sufficiently competent to practice this approach frequently. Methods: The study has a cross-sectional design, with 65 wards (46 Belgian nursing homes) participating in the study. We compared nursing home professionals’ and residents’ perspectives on the level of shared decision-making during advance care planning conversations with ratings from external raters. Residents and professionals rated the level of shared decision-making by means of a questionnaire, which included the topic of the conversation. External raters assessed audio recordings of the conversations. Professionals filled in an additional self-report questionnaire on the importance of shared decision-making, their competence in practicing the approach, and with what frequency.Results: At ward level, professionals and residents rated the average achieved level of shared decision-making 71.53/100 (σ=16.09) and 81.11/100 (σ=19.18) respectively. Meanwhile, raters gave average scores of 26.97/100 (σ=10.45). Only 23.8% of residents referred to advance care planning as the topic of the conversation. Professionals considered shared decision-making to be important (x̄=4.48/5, σ=0.26). This result contrasted significantly with the frequency (x̄=3.48/5, σ=0.51) and competence (x̄=3.76/5, σ=0.27) with which these skills were practiced (P<0.001).Conclusions: Residents with dementia are grateful when involved in discussing their care, but find it difficult to report what is discussed during these conversations. Receiving more information about advance care planning could provide them with the knowledge needed to prepare for such a conversation. External raters observe a discrepancy between the three-talk model and daily practice methods. Training programs should focus on providing professionals with better knowledge of and skills for shared decision-making. They should also promote team-based collaboration to increase the level of person-centered care in nursing home wards for persons with dementia.
Measuring the prevalence of 60 health conditions in older Australians in residential aged care with electronic health records: a retrospective dynamic cohort study
Authors: Lind Kimberly E. , Raban Magdalena Z. , Brett Lindsey , Jorgensen Mikaela L. , Georgiou Andrew , Westbrook Johanna I.
Published: September 2020

Background: The number of older Australians using aged care services is increasing, yet there is an absence of reliable data on their health. Multimorbidity in this population has not been well described. A clear picture of the health status of people using aged care is essential for informing health practice and policy to support evidence-based, equitable, high-quality care. Our objective was to describe the health status of older Australians living in residential aged care facilities (RACFs) and develop a model for monitoring health conditions using data from electronic health record systems. Methods: Using a dynamic retrospective cohort of 9436 RACF residents living in 68 RACFs in New South Wales and the Australian Capital Territory from 2014-2017, we developed an algorithm to identify residents’ conditions using: aged care funding assessments; medications administered; and clinical notes from their facility electronic health record (EHR). We generated age and sex-specific prevalence estimates for 60 health conditions. Agreement between conditions recorded in aged care funding assessments and those documented in residents’ EHRs was evaluated using Cohen’s Kappa. Cluster analysis was used to describe combinations of health conditions (multimorbidity) occurring among residents.Results: Using all data sources, 93% of residents had some form of circulatory disease, with hypertension the most common (62%). Most residents (93%) had a mental or behavioural disorder, including dementia (58%) or depression (54%). For most conditions, EHR data identified approximately twice the number of people with the condition compared to aged care funding assessments. Agreement between data sources was highest for multiple sclerosis, Huntington’s disease and dementia. The cluster analysis identified seven groups with distinct combinations of health conditions and demographic characteristics and found that the most complex cluster represented a group of residents that had on average the longest lengths of stay in residential care.Conclusions: The prevalence of many health conditions among RACF residents in Australia is underestimated in previous reports. Aged care EHR data have the potential to be used to better understand the complex health needs of this vulnerable population and can help fill the information gaps needed for population health surveillance and quality monitoring.
A longitudinal study of the turning points and trajectories of therapeutic relationship development in occupational and physical therapy
Authors: Horton Ayana , Hebson Gail , Holman David
Published: September 2020

Background The importance of the therapeutic relationship is widely recognised across healthcare professions. Despite the importance of therapeutic relationships, there are significant gaps in the knowledge base on how these relationships develop. To address these gaps, this study explores relationship dynamics by identifying relational turning points and trajectories in therapeutic relationships between occupational therapists and physical therapists and their patients. The implications for how a focus on these relational aspects can enhance clinical practice will be discussed.Methods Data collection was based on the Retrospective Interview Technique and consisted of two phases. In the first phase patients and therapists were asked to tell the story of their therapeutic relationship development and as part of this, identify the turning points that occurred. In the second phase, therapists-patient dyads were observed from their first interaction to their last to identify potential turning points and at the end of the relationship a participant verification interview was conducted with both dyadic partners individually. Template analysis was used to analyse the data.Results Therapists identified 6 distinct categories of turning points; Progress Towards Goals, Set-backs in Progress Towards Goals, Interpersonal Affective Bonding with Patients, Interpersonal Problems with Patients, Positive Feedback, and Negative Feedback. Patients identified 5 categories of turning points; Progress Towards Goals, Set-backs in Progress Towards Goals, Interpersonal Affective Bonding with Therapists, Agreement with Therapist and Change in Treatment. These turning points varied regarding their impact on the trajectory of the therapeutic relationship. The trajectory patterns identified were stable, upward, downward, and multidirectional.Conclusion This study makes an important contribution to our understanding of therapeutic relationship dynamics in the occupational and physical therapy context. The results expose the challenges that therapists and patients face in building high-quality therapeutic relationships, the diversity of therapeutic relationships, and how these relationships develop over time. This is the first study to use a turning point analysis in research on therapeutic relationships.
Clinical Application of Intracranial Pressure Monitoring Based on Flash Visual Evoked Potential in Treatment of Patients with Hypertensive Intracerebral Hemorrhage
Authors: Yu Fangping , Zhao Yingchun , Zhang Yu , Luan Xinghua , Wu Ying
Published: September 2020

Objective To investigate the application value of flash visual evoked potential (FVEP) noninvasive intracranial pressure (nICP) monitoring technology in patients with hypertensive intracerebral hemorrhage (HICH). Methods There were 116 eligible subjects included in the experiment, the final sample size was 102 for this study. They were randomly divided into FVEP nICP monitoring group (experimental group) and the non-monitoring group (control group). The experimental group were examined lumbar puncture immediately after intracranial pressure was monitored by FVEP. Mannitol was used in reducing the elevated intracranial pressure. The serum concentrations of creatinine and urea nitrogen were recorded to assess the renal function. To evaluate the efficacy of FVEP nICP monitoring technique for clinical adjustment of mannitol. The Glasgow prognosis scores (GOS) were evaluated for patients' prognosis between two groups. Results There was no statistical significance between FVEP nICP measurement and lumbar puncture intracranial pressure measurement (195.76 ±58.88 mmH2O vs 197.04 ±53.72 mmH2O, P>0.05). Linear correlation analysis indicated that there was a strong positive relationship between the measurements (r=0.950, P<0.01). The duration prescription time and the average usage amount of mannitol in the experimental group was significantly less than that in the control group (P< 0.05), and the serum creatinine and urea nitrogen concentrations in the two groups were not statistically significant (P> 0.05). The cure rate of the experimental group was higher than that of the control group (χ2=3.889, P=0.048). Conclusion FVEP nICP monitoring technology could replace invasive intracranial pressure monitoring technology in part HICH patients. The application of FVEP nICP technique can reduce the dosage of mannitol and improve the prognosis of patients with HICH.
Revealing oral microbiota composition and functionality associated with heavy cigarette smoking.
Authors: Albataineh Mohammad Tahseen , Dash Nihar Ranjan , Elkhazendar Mohammed , Alnusairat Dua'a Mohammad Hasan , Darwish Islam Mohammad Ismail , Al-Hajjaj Mohamed Saleh , Hamid Qutayba
Published: September 2020

Background: Heavy tobacco smoking, a hallmark feature of lung cancer, is drastically predominant in Middle Eastern populations. The precise links between nicotine dependence and the functional contribution of the oral microbiota remain unknown in these populations.Methods: We evaluated the composition and functional capabilities of oral microbiota with relation to cigarette smoking in 105 adults through shotgun metagenomics using buccal swabs. Results: The oral microbiota composition in our study subjects was dominated by the phyla Firmicutes, Proteobacteria, Actinobacteria, and Bacteroidetes, in addition to the genera Prevotella and Veillonella, similar to previously described westernized cohorts. Furthermore, the smoker's oral microbiota represented a significant abundance of Veillonella dispar, Leptotrichia spp., and Prevotella pleuritidis when compared to non-smokers. Within the smoking groups, differential relative abundance testing unveiled relative abundance of Streptobacillus hongkongensis, Fusobacterium massiliense, Prevotella bivia in high nicotine dependent compared to low nicotine dependent profiles based on Fagerström Test for Nicotine Dependence. Functional profiling showed marked differences between smokers and non-smokers. Smokers exhibited an enrichment of Tricarballylate utilization and Lactate racemization when compared to the non-smokers. According to their nicotine dependence, enrichment of Xanthosine utilization, p-Aminobenzoyl-Glutamate utilization, and multidrug efflux pump in Campylobacter jejuni biosynthesis modules were detected in the high nicotine dependent group. Conclusions: These compositional and functional differences may provide critical insight on how variations in the oral microbiota could predispose to respiratory illnesses and smoke cessation relapse in cigarette smokers. In particular, the observed enrichment of Fusobacterium and Prevotella in the oral microbiota possibly suggests an intriguing linkage to gut and lung cancers.
End-stage knee osteoarthritis with and without sarcopenia and the effect of knee arthroplasty – a prospective cohort study
Authors: Ho Kevin Ki-Wai , Lau Lawrence Chun-Man , Chau Wai Wang , Poon Queena , Chung Kwong-Yin , Wong Ronald Man-Yeung
Published: September 2020

Background: Sarcopenia often accompanies osteoarthritis (OA) which is managed by total knee arthroplasty (TKA) in late stage. Recent studies have suggested higher risk of post-operative complication after TKA in sarcopenic OA subjects but whether TKA can benefit them as for non-sarcopenic subjects remain unexplored. This study aims to examine the dynamic, mutual impact of sarcopenia and TKA in their one-year post-operative period.Methods: This prospective cohort study was conducted between 2015 to 2018 at our hospital. Patients with end-stage OA of the knee waiting for TKA were recruited into the study. Primary outcome measures were change in muscle strength, mass and function. Secondary outcome measures were Quality of Life (QOL) measurements in pain, psychological and physical health.Results: Fifty-eight patients were recruited, of which 79.3% were female and 32.8% already had sarcopenia at baseline. The average age of sarcopenic subjects and non-sarcopenic subjects were comparable (67.89±7.07 vs. 67.92±6.85; p=0.99) and sarcopenic subjects had lower body mass index (BMI) (25.64±2.64 vs. 28.57±4.04; p=0.01). There was a statistically significant improvement in walking speed (10.24±5.35 vs 7.69±2.68, p<0.01) and muscle strength in both sarcopenic and non-sarcopenic patients after TKA. This was accompanied by an improvement trend in muscle mass in all subjects. There was no change in handgrip power before and after TKA and subsequent follow-up (p=0.97). Quality of life measured with WOMAC, SF12v2 and IPAQ revealed progressive significant improvement (p≤0.01). Further analysis at the IPAQ also found increased engagement of high-intensity activities.Conclusions: This study showed that sarcopenia among patients with end-stage OA of the knee is not uncommon but both sarcopenic and non-sarcopenic OA patients could reach significant clinical and functional improvement after TKA. Further studies with increased sample size and different ethnicities can help ascertain a beneficial role of TKA on sarcopenic OA subjects.
High Anemia Prevalence in Korean Older Adults, an Advent Healthcare Problem: 2007-2016 KNHANES
Authors: Chueh Hee won , Jung Hye Lim , Shim Ye Jee , Choi Hyoung Soo , Han Jin Yeong
Published: September 2020

BACKGROUND: Anemia is associated with high morbidity and mortality in older people. However, anemia in older individuals is not fully understood, and national data on the prevalence and characteristics of anemia in Korean older people are lacking. This study aimed to evaluate the prevalence and characteristics of anemia in older adults using data from the Korea National Health and Nutrition Examination Survey (KNHANES), which is the nation-wide cross-sectional epidemiological study conducted by Korean Ministry of Health and Welfare.Methods: Data from the total of 62,825 participants of the 2007-2016 KNHANES were merged and analyzed to investigate differences in participant characteristics and potential risk factors for anemia. Differences in participant characteristics were compared across subgroups using the chi-squared test for categorical variables and independent t-test for continuous variables. Univariate and multivariate analyses using logistic regression were performed to identify related clinical factors.RESULTS: The prevalence of anemia was higher in the population aged ≥65 years than in the younger population. Anemia was also more prevalent among females than among males, but the difference was not statistically significant in people aged >85 years. Being underweight, receiving a social allowance, living alone, and having comorbidities such as hypertension, rheumatoid arthritis, diabetes mellitus (DM), cancer, and chronic renal failure (CRF) were more prevalent in older adults with anemia than in the group without anemia. In the univariate and multivariate analyses, older age, female sex, underweight, and comorbidities including rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia. CONCLUSIONS: This study revealed that age, female sex, underweight, and the presence of comorbidities such as rheumatoid arthritis, DM, cancer, and CRF were associated with an increased risk of anemia in Korean older adults. Further study on causal relationships between anemia and other variables in the older population is necessary.
LncRNA-SNHG6 promotes the progression of hepatocellular carcinoma by targeting miR-6509-5p and HIF1A
Authors: Fan Xiaoxi , Zhao Zhongwei , Song Jingjing , Zhang Dengke , Wu Fazong , Tu Jianfei , Xu Min , Ji Jiansong
Published: September 2020

Background: Accumulating evidences has been reported that long noncoding RNAs play crucial roles in the progression of hepatocellular carcinoma (HCC). SnoRNA host gene 6 (SNHG6) is believed to be involved in several human cancers, but the specific molecular mechanism of SNHG6 in HCC is not well studied. Methods: In this study, we experimentally down-regulated the SNHG6 in two hepatocellular carcinoma cell lines, and measured the proliferation, migration and invasion abilities and the apoptotic levels in vitro. Also, we performed the xenograft assay to investigate the function of SNHG6 during the tumor growth. Results: We found SNHG6 was highly expressed in HCC tissues. Next, using Hep3B and Huh7 cells, we confirmed knockdown of SNHG6 could reduce the proliferation, migration and invasion abilities in vitro. Also, by bioinformatics analysis, further molecular and cellular experiments, we found miR-6509-5p bound to SNHG6 directly, and the expression level of HIF1A was regulated through SNHG6/miR-6509-5p axis. Finally, we found that down-regulation of SNHG6 could dramatically reduce the tumor growth ability of Huh7 cells in vivo . Conclusions: We concluded that SNHG6/miR-6509-5p/ HIF1A axis functioned in the progression of hepatocellular carcinoma, and could be the promising therapeutic targets in hepatocellular carcinoma.
Multiprofessional Medication Management (MuMM) Intervention Aiming at Enhancing the Tolerability of Cancer Chemotherapy: A Randomized Feasibility Trial
Authors: Wilmer André , Vucur Corinna , Tasar Andrea , Klima Katharina , Fleckenstein Katrin , Puth Marie-Therese , Mitchell Sandra , Ruberg Klaus , Schmid Matthias , Ko Yon D. , Jaehde Ulrich
Published: September 2020

Background: A newly developed multiprofessional medication management (MuMM) intervention in an oncologic outpatient care setting was evaluated for its feasibility to enhance the tolerability of cancer-directed therapy. The intervention consisted of a basic care module for medication review including drug-drug interaction checks, and four supplementary modules for the management of common adverse events, specifically nausea/vomiting, mucositis, fatigue, and pain.Methods: A single-centre, unblinded, randomized two-arm trial was conducted in the oncologic outpatient ward of a municipal hospital in Bonn, Germany, with an associated community pharmacy. Feasibility of the intervention was assessed by analyzing the application of supplementary modules and semi-structured interviews with the participating health care providers. Symptom burden was assessed as primary outcome by the Patient-Reported Outcomes version of the Common Terminology Criteria for Adverse Events (PRO-CTCAE). Furthermore, health-related quality of life and patient satisfaction with received information were analyzed.Results: 51 patients were randomized either to a control group receiving standard care (25 patients) or the intervention group receiving MuMM (26 patients). The results indicate that the MuMM intervention delivered by physicians, pharmacists, and nurses is needed and feasible, but hampered by several barriers concerning cooperation and communication within the multiprofessional health care team. The intervention did not affect symptom burden, quality of life, and patient satisfaction.Conclusion: The degree of implementation of the MuMM intervention was apparently not high enough to show a preliminary efficacy signal. Nevertheless, our study provides a starting point and methodological framework for future trials aiming at enhancing the tolerability of cancer-directed therapy.TRIAL REGISTRATION NUMBERDRKS00010128 at the German Clinical Trials Register (DRKS) Date of registration: March 7th, 2016 (retrospectively registered)
Analysis of the role of the human papillomavirus 16/18 E7 protein assay in screening for cervical intraepithelial neoplasia: a case control study
Authors: Kong Linghua , Xiao Xiaoping , Lou Huiping , Liu Pengfei , Song Shuhui , Liu Moudu , Xu Tao , Zhang Ying , Li Caijuan , Guan Ruoli , Li Yan , Yu Xin , Liu Haiyuan , Fan Qingbo , Shi Honghui , Zhu Lan
Published: September 2020

Background: Cervical cancer is the second-most common gynecological cancer, early screening plays a key role in the diagnosis and treatment of cervical intraepithelial neoplasia (CIN). Sustained E7 protein expression is the pathological basis for CIN and cervical cancer. Methods: We collected the cervical cell samples of women who visited the gynecological clinic of Peking Union Medical College Hospital between September 2018 and September 2019 and submitted them to the high-risk human papillomavirus (Hr-HPV) test. We performed a magnetic particle–based chemiluminescence enzyme immunoassay to analyze the HPV16/18 E7 protein level in CIN of different severities and compared the results with those of cervical pathology (gold standard) and the HPV test. Results: The positive rate of HPV16/18 E7 protein increased with the severity of CIN: 26.6% in normal tissue, 58.3% in CIN1, and 70.6% in CIN2 or higher (CIN2+). For CIN2+, the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the E7 protein were 70.6%, 67.9%, 52.2%, and 82.3%, respectively. These values of the HPV test were 86.8%, 44.5%, 43.7%, and 87.1%, respectively. With the combination of the E7 protein assay and HPV test, the specificity for diagnosing CIN2+ was 78.1%, which was significantly higher than that of the HPV test alone. Conclusions: HPV16/18 E7 protein level is correlated with the severity of CIN and has a high concordance rate with the pathological result. For cervical cancer screening, the combination of HPV16/18 E7 protein assay and HPV test improves the CIN diagnostic specificity, detection rate, and detection accuracy.
Assessment of chronic disease self-management in patients with chronic heart failure based on the MCID of patient-reported outcomes by the multilevel model
Authors: Tian Jing , Zhao Jinghua , Zhang Qing , Ren Jia , Han Linai , Li Jing , Zhang Yanbo , Han Qinghua
Published: September 2020

Purpose: The minimal clinically important difference (MCID) of a patient-reported outcome (PRO) represents the threshold value of the change in the score for that PRO. It is deemed to have an important implication in clinical management. This study was performed to evaluate the clinical significance of chronic disease self-management (CDSM) for patients with chronic heart failure based on the MCID of the chronic heart failure - PRO measure (CHF-PROM).Methods: A multicenter, prospective cohort study of 555 patients with heart failure were enrolled from July 2018. Advice of CDSM was provided in written form at discharge to all patients. Information regarding CHF-PROM and CDSM were collected during follow-up. Multilevel models were applied to dynamically evaluate the effects of CDSM for CHF-PROM scores, as well as its physical and psychological domains. MCID changes of the PRO were introduced and compared with β values of CDSM obtained from the multi-level models to further evaluate the clinical significance.Results: Scores for CHF-PROM improved significantly after discharge. The multilevel models showed that a regular schedule, avoidance of over-eating, a low-sodium diet and exercise increased scores on CHF-PROM. Compared with the MCID, avoidance of over-eating (12.39 vs. 9.75) and maintenance of a regular schedule often (10.98 vs. 9.75), and exercise almost every day (11.36 vs. 9.75) reached clinical significance for the overall summary. Avoidance of over-eating (5.88 vs. 4.79) and a regular schedule almost every day (4.96 vs. 4.79) reached clinical significance for the physical scores. Avoidance of over-eating half of the time (5.26 vs. 4.87) and a regular schedule almost every day (5.84 vs. 4.87) demonstrated clinical significance for the psychological scores.Conclusions: This study observed an association of avoidance of over-eating and maintenance of a regular schedule with the improvement of CHF-PROM. It provides further evidence for management of heart failure.Trial registration: 2018LL128, Registered January 2, 2018- Prospective registered, http://www.sxmu.edu.cn/.
A multilevel analysis of the importance of oral health instructions for preventing tooth loss: The 8020 Promotion Foundation Study of Japanese Dental Patients
Authors: Saito Mizuki , Shimazaki Yoshihiro , Fukai Kakuhiro , Furuta Michiko , Aida Jun , Ando Yuichi , Miyazaki Hideo , Kambara Masaki
Published: September 2020

Background: Many studies have reported risk factors for tooth loss. Oral health instruction is considered effective at improving oral health behavior and oral health. However, few studies have examined the relationship of dental clinic factors, such as the number of dental hygienists and implementation of oral health instructions, with tooth loss. Here, we conducted a multilevel analysis to clarify the dental clinic risk factors associated with tooth loss.Methods: Baseline surveys were conducted at 1,216 dental clinics in 46 prefectures in Japan, and 12,399 dental patients aged 20 years and over underwent oral examinations and completed a questionnaire. The dental clinics also completed a questionnaire at baseline. A 3-year follow-up survey included 2,488 patients in 585 dental clinics. Multilevel multivariate logistic regression analysis was used to examine the risk of tooth loss at the patient and clinic levels.Results: Of the patient variables, older age, higher mean probing pocket depth, current or past smoking, and bleeding during tooth brushing were associated with higher risks of tooth loss. Individuals with many teeth who visited dental clinics for maintenance were at significantly lower risk of tooth loss. Of the clinic variables, patients attending dental clinics with four or more dental hygienists had a significantly lower risk of tooth loss (OR 0.67, 95% CI 0.50–1.00). Patients attending dental clinics that provide oral health instructions for 20 min or more had a significantly lower risk of tooth loss (OR 0.69, 95% CI 0.50–0.96).Conclusions: In addition to individual risk factors for tooth loss, dental clinic factors such as length of oral health instruction and number of dental hygienists are associated with tooth loss. In dental clinics, ensuring sufficient time for dental hygienists to provide oral health instructions can help prevent tooth loss in dental patients.