bluuebunny/crossref_metadata_2025 huggingface dataset:
Microchannel Structural Design For a Room-Temperature Liquid Metal Based Super-stretchable Sensor
Authors: Gao Qinwu , Li Hui , Zhang Jinjie , Xie Zhenwen , Zhang Jinyong , Wang Lei
Published: April 2019

Room-temperature liquid metal has been widely used in flexible and stretchable sensors, focusing on embedding liquid metal in microchannels, liquid metal microdroplets formation, captive sensors, and liquid metal nanoparticles, etc. In this paper, a facile Eutectic Galium-Indium (EGaln) liquid-based microfluidic high-sensitivity, skin-mountable, and ultra-soft stretchable sensor is developed. It comprises Ecoflex microfluidic assembly filled with EGaln, which serves as the working fluid of the stretchable sensor. The lithography method is applied to achieve microfluidic channel. The microfluidic channel is optimized by using topology method and finite element analysis, making this device with high conformability and high stretchability. This method achieved an outstanding effect on elastomer-encapsulated strain gauge, which displays an approximately linear behavior with a gauge factor (GF). The GF could reach as high as 4.95 when the strain ultimately reached 550%. Applications of detection of the joints, fingers, and wrists has been conducted and showed excellent results. This work can further facilitate the exploration and potential realization of a functional liquid-state device technology with superior mechanical flexibility and conformability.
Adaptively Weighted and Robust Mathematical Programming for the Discovery of Driver Gene Sets in Cancers
Authors: Xu Xiaolu , Qin Pan , Gu Hong , Wang Jia , Wang Yang
Published: April 2019

High coverage and mutual exclusivity (HCME), which are considered two combinatorial properties of mutations in a collection of driver genes in cancers, have been used to develop mathematical programming models for distinguishing cancer driver gene sets. In this paper, we summarize a weak HCME pattern to justify the description of practical mutation datasets. We then present AWRMP, a method for identifying driver gene sets through the adaptive assignment of appropriate weights to gene candidates to tune the balance between coverage and mutual exclusivity. It embeds the genetic algorithm into the subsampling strategy to provide the optimization results robust against the uncertainty and noise in the data. Using biological datasets, we show that AWRMP can identify driver gene sets that satisfy the weak HCME pattern and outperform the state-of-arts methods in terms of robustness.
Bulk poly(N-isopropylacrylamide) (PNIPAAm) thermoresponsive cell culture platform: toward a new horizon in cell sheet engineering
Authors: Choi Andrew , Seo Kyoung Duck , Yoon Hyungjun , Han Seon Jin , Kim Dong Sung
Published: April 2019

In contrast to the conventional ‘grafting’-based thermoresponsive cell culture platform, we first developed a bulk form of thermoresponsive cell culture platform for attaching/detaching diverse types and origins of the cell sheets in different shape.
fac-Re(CO)3-based neutral heteroleptic tetrahedrons
Authors: Arumugam Ramar , Shankar Bhaskaran , Soumya K. R. , Sathiyendiran Malaichamy
Published: April 2019

fac-Re(CO)3-based synthetic approach i.e., combination of rigid dianionic bis-chelating donor, flexible neutral ditopic nitrogen donor and Re2(CO)10, for neutral, heteroleptic tetrahedral shaped supramolecular coordination complexes was designed.
Brosimone I, an isoprenoid-substituted flavonoid, induces cell cycle G1phase arrest and apoptosis through ROS-dependent endoplasmic reticulum stress in HCT116 human colon cancer cells
Authors: Zhao Yueliang , Zhou Yue , Wang Mingfu
Published: April 2019

Brosimone I, an isoprenoid-substituted flavonoid fromArtocarpus heterophyllus, induces cell growth inhibition through the induction of ROS-mediated increased cytosolic Ca2+, ER stress, and the activation of the CaMKK-AMPK pathway.
Zinc oxide nanocrystals as a nanoantibiotic and osteoinductive agent
Authors: Garino Nadia , Sanvitale Pasquale , Dumontel Bianca , Laurenti Marco , Colilla Montserrat , Izquierdo-Barba Isabel , Cauda Valentina , Vallet-Regì Maria
Published: April 2019

Nanomaterials for bone tissue engineering are developing to new solutions against infections, antibiotic resistance, promotion of new bone. ZnO nanocrystals are promising candidates with intrinsic antimicrobial activity and high biocompatibility.
Exploring potential biomarkers of coronary heart disease treated by Jing Zhi Guan Xin Pian using high-throughput metabolomics
Authors: Sun Hui , Li Xue-na , Zhang Ai-hua , Zhang Kun-ming , Yan Guang-li , Han Ying , Wu Fang-fang , Wang Xi-jun
Published: April 2019

Coronary heart disease (CHD) is a relatively complex disease characterized by narrowing of the arterial lumen and reduction of blood flow to the heart.
Photocatalytic properties of a new Z-scheme system BaTiO3/In2S3 with a core–shell structure
Authors: Wei Kaili , Wang Baolai , Hu Jiamin , Chen Fuming , Hao Qing , He Guannan , Wang Yinzhen , Li Wei , Liu Junming , He Qinyu
Published: April 2019

It's highly desired to design an effective Z-scheme photocatalyst with excellent charge transfer and separation, a more negative conduction band edge (ECB) than O2/·O2− (−0.33 eV) and a more positive valence band edge (EVB) than ·OH/OH− (+2.27 eV).
Combined molecular docking, homology modelling and density functional theory studies to modify dioxygenase to efficiently degrade aromatic hydrocarbons
Authors: Li Xingchun , Chu Zhenhua , Du Xianyuan , Qiu Youli , Li Yu
Published: April 2019

To promote the biodegradation of aromatic hydrocarbons in petroleum-contaminated soils, naphthalene dioxygenase (NDO), which is the key metabolic enzyme that degrades aromatic hydrocarbons, was modified using molecular docking and homology modelling.
Laboratory EXAFS determined structure of the stable complexes in the ternary Ni(ii)–EDTA–CN− system
Authors: Németh Zoltán , Bajnóczi Éva G. , Csilla Bogdán , Vankó György
Published: April 2019

Aqueous solutions of the ternary system Ni(ii)–EDTA–CN− are investigated with X-ray Absorption Spectroscopy (XAS) as a function of cyanide concentration with an enhanced laboratory von Hámos X-ray spectrometer.
The sulfonate group as a ligand: a fine balance between hydrogen bonding and metal ion coordination in uranyl ion complexes
Authors: Thuéry Pierre , Atoini Youssef , Harrowfield Jack
Published: April 2019

Nine uranyl sulfonate complexes display various association modes of sulfonate groups, either coordinating or acting as hydrogen bond acceptors.
A carob-inspired nanoscale design of yolk–shell Si@void@TiO2-CNF composite as anode material for high-performance lithium-ion batteries
Authors: Zhang Chenle , Yang Jingbo , Mi Hongwei , Li Yongliang , Zhang Peixin , Zhang Han
Published: April 2019

The one-dimensional yolk–shell structured Si@void@TiO2-CNF anode delivers improved specific capacity and cycling performance for lithium ion batteries.
Efficient minority carrier detrapping mediating the radiation hardness of triple-cation perovskite solar cells under proton irradiation
Authors: Lang Felix , Jošt Marko , Bundesmann Jürgen , Denker Andrea , Albrecht Steve , Landi Giovanni , Neitzert Heinz-Christoph , Rappich Jörg , Nickel Norbert H.
Published: April 2019

Although highly energetic proton irradiation forms localized trap states in triple cation perovskites, solar cells possess exceptional radiation hardness.
Facet-dependent evolution of surface defects in anatase TiO2 by thermal treatment: implications for environmental applications of photocatalysis
Authors: Li Tong , Shen Zelin , Shu Yiling , Li Xuguang , Jiang Chuanjia , Chen Wei
Published: April 2019

Exposed crystal facets of TiO2 nanomaterials significantly affect the surface defect formation of the materials during thermal treatment.
R-phycoerythrin extraction and purification from freshGracilariasp. using thermo-responsive systems
Authors: Vicente Filipa A. , Cardoso Inês S. , Martins Margarida , Gonçalves Cátia V. M. , Dias Ana C. R. V. , Domingues Pedro , Coutinho João A. P. , Ventura Sónia P. M.
Published: April 2019

Besides the good performance, the downstream process based in thermo-responsive systems was shown to be efficient and of lower environmental impact.
A new practical isobaric interference correction model for thein situHf isotopic analysis using laser ablation-multi-collector-ICP-mass spectrometry of zircons with high Yb/Hf ratios
Authors: Gu Hai-Ou , Sun He , Wang Fangyue , Ge Can , Zhou Taofa
Published: April 2019

An isobaric interference correction model was proposed for thein situHf isotopic analysis of zircons with high Yb/Hf ratios using LA-MC-ICP-MS.
Glow discharge optical emission spectrometry for quantitative depth profiling of CIGS thin-films
Authors: Kodalle Tim , Greiner Dieter , Brackmann Varvara , Prietzel Karsten , Scheu Anja , Bertram Tobias , Reyes-Figueroa Pablo , Unold Thomas , Abou-Ras Daniel , Schlatmann Rutger , Kaufmann Christian A. , Hoffmann Volker
Published: April 2019

The article demonstrates how quantitative compositional depth profiles of Cu(In,Ga)(S,Se)2layers can be utilized to determine their energy bandgap distribution.
Nanosurfer flash-mobs: electric-field-choreographed silver migration on graphene oxide
Authors: Leow Yong Han Jerome , Lim Patria Yun Xuan , Lim Sharon Xiaodai , Wu Jianfeng , Sow Chorng-Haur
Published: April 2019

A silver dendrite assisted micro-display on a GO film, whose visibility is tunable by an externally applied potential, is created.
A combined experimental and theoretical approach to investigate the structure, magnetic properties and DNA binding affinity of a homodinuclear Cu(ii) complex
Authors: Ahamad M. Naqi , Shahid M. , Ansari Azaj , Kumar Manjeet , Khan Ishaat M. , Ahmad Musheer , Rahisuddin Rahisuddin , Arif Rizwan
Published: April 2019

A dicopper(ii) complex of a flexible amino alcohol anchored with an acetate auxiliary was designed and characterized by spectral, X-ray crystallographic, magnetic and DFT studies; moreover, it was evaluated for its DNA binding properties. The experimental results are supported by theoretical analyses.
Dual-band in situ molecular spectroscopy using single-sized Al-disk perfect absorbers
Authors: Dao Thang Duy , Chen Kai , Nagao Tadaaki
Published: April 2019

Plasmonic perfect absorbers with a single-sized resonator for simultaneous sensitive dual-band vibrational sensing and real-time observation of molecular reaction kinetics were proposed.
Evaluating aryl esters as bench-stable C(1)-ammonium enolate precursors in catalytic, enantioselective Michael addition–lactonisations
Authors: Young Claire M. , Taylor James E. , Smith Andrew D.
Published: April 2019

An evaluation of a range of aryl, alkyl and vinyl esters as prospective C(1)-ammonium enolate precursors in enantioselective Michael addition–lactonisation processes with (E)-trifluoromethylenones using isothiourea catalysis is reported.
Drastic photoluminescence modulation of an organic molecular crystal with high pressure
Authors: Guan Junjie , Zhang Chunfang , Gao Dexiang , Tang Xingyu , Dong Xiao , Lin Xiaohuan , Wang Yajie , Wang Xinxin , Wang Lin , Lee Hyun Hwi , Xu Jialiang , Zheng Haiyan , Li Kuo , Mao Ho-kwang
Published: April 2019

The pressure-induced phase transition of diphenylfluorenone leads to a drastic redshift of the photoluminescence spectra from greenish-yellow to the near-infrared region.
(E)-Selective Friedel–Crafts acylation of alkynes to β-chlorovinyl ketones: defying isomerizations in batch reactions by flow chemistry approaches
Authors: Koo Hyungmo , Kim Hun Young , Oh Kyungsoo
Published: April 2019

Flow chemistry approaches provide a fast, clean, and stereoselective synthetic route to (E)-β-chlorovinyl ketones, free from inherent (E) → (Z) isomerization.
Selective synthesis of N-protected exo-spiro[oxirane-3,2′-tropanes]
Authors: Mandzhulo Aleksandr , Vashchenko Iryna , Gerasov Andrii , Vovk Mykhaylo , Rusanov Eduard , Fetyukhin Volodymyr , Lukin Oleg , Shivanyuk Alexander
Published: April 2019

N-Cbz- and N-Boc-protected exo-spiro[oxirane-3,2′-tropanes] were selectively synthesized via either epoxidation or hydroxybromination/dehydrobromination of the corresponding alkenes.
Comparative study on gas sensing by a Schottky diode electrode prepared with graphene–semiconductor–polymer nanocomposites
Authors: Biswas Md Rokon Ud Dowla , Oh Won-Chun
Published: April 2019

This paper studies the performance of a gas sensor based on an organic/inorganic diode for ammonia (NH3), nitrogen (N2) & oxygen (O2) sensing under atmospheric conditions at room temperature and different humidity levels.
Contact lenses for continuous corneal temperature monitoring
Authors: Moreddu Rosalia , Elsherif Mohamed , Butt Haider , Vigolo Daniele , Yetisen Ali K.
Published: April 2019

Temperature variation is a ubiquitous medical sign to monitor ocular conditions including dry eye disease (DED), glaucoma, carotid artery stenosis, diabetic retinopathy, and vascular neuritis.
Experimental and theoretical investigation of oxidative methane activation on Pd–Pt catalysts
Authors: Qi Wenjie , Huang Zehao , Chen Zheming , Fu Lijuan , Zhang Zhigang
Published: April 2019

Density functional theory and measurements of rate are used to provide evidence for the rate determining step and requirements of the active site for CH4 combustion on Pd–Pt bimetallic catalysts in five different distinct kinetic regimes.
Rechargeable aluminum batteries: effects of cations in ionic liquid electrolytes
Authors: Zhu Guanzhou , Angell Michael , Pan Chun-Jern , Lin Meng-Chang , Chen Hui , Huang Chen-Jui , Lin Jinuan , Achazi Andreas J. , Kaghazchi Payam , Hwang Bing-Joe , Dai Hongjie
Published: April 2019

Room temperature ionic liquids (RTILs) are solvent-free liquids comprised of densely packed cations and anions. Properties of Py13Cl–AlCl3 ILs were studied and compared with EMIC-AlCl3 ILs for use as electrolyte in Al–graphite battery.
A clean and effective potassium hydroxide pretreatment of corncob residue for the enhancement of enzymatic hydrolysis at high solids loading
Authors: Chi Xuewen , Liu Chao , Bi Yan-Hong , Yu Guang , Zhang Yuedong , Wang Zhaoyu , Li Bin , Cui Qiu
Published: April 2019

The effective KOH pretreatment with the production of lignin-based fertilizer could well match the enzymatic hydrolysis at high solid loading.
Importance of the biofilm matrix for the erosion stability of Bacillus subtilis NCIB 3610 biofilms
Authors: Klotz M. , Kretschmer M. , Goetz A. , Ezendam S. , Lieleg O. , Opitz M.
Published: April 2019

Erosion of bacterial biofilms is dependent on the composition of the biofilm matrix and the surrounding chemical environment.
Promoted high temperature carrier mobility and thermoelectric performance of InTe enabled by altering scattering mechanism
Authors: Zhu Huaxing , Zhang Bin , Wang Guiwen , Peng Kunling , Yan Yanci , Zhang Qing , Han Xiaodong , Wang Guoyu , Lu Xu , Zhou Xiaoyuan
Published: April 2019

Sb nano-precipitates, which serve to alter the vibrational frequency of localized phonon modes that facilitate inter-valley scattering, emerge in pristine InTe after addition of Sb. As a result, exponentially declined carrier mobility is promoted by nearly 50% at 723 K in InTe–Sb0.01, leading to enhanced thermoelectric performance.
Post-synthesis deposition of mesoporous niobic acid with improved thermal stability by kinetically controlled sol–gel overcoating
Authors: Du Yuan-Peng , Héroguel Florent , Nguyen Xuan Trung , Luterbacher Jeremy S.
Published: April 2019

An ordered mesoporous niobia catalyst is synthesized by niobia overcoating on silica and shows high activity and stability for acid catalysis.
High-performance organic light-emitting diodes with low-efficiency roll-off using bulky tetradentate [Pt(O^N^C^N)] emitters
Authors: Mao Mao , Peng Jiahuan , Lam Tsz-Lung , Ang Wai-Hung , Li Huiyang , Cheng Gang , Che Chi-Ming
Published: April 2019

Double-host OLEDs with three bulky tetradentate [Pt(O^N^C^N)] emitters achieve a high EQEmax of >20%, a PEmax of >100 lm W−1, and low efficiency roll-off within 10 000 cd m−2.
MiRNA-506 inhibits rheumatoid arthritis fibroblast-like synoviocytes proliferation and induces apoptosis by targetting TLR4
Authors: Li Dan , Zhou Qingchen , Hu Gaojian , Wang Gang
Published: April 2019

Fibroblast-like synoviocytes (FLSs) play a crucial role in rheumatoid arthritis (RA) pathogenesis. While miRNA (miR)-506 has been implicated in the progression of multiple diseases, its role in RA remains to be explored. The present study evaluated the function of miR-506 in the regulation of RA-FLSs. FLSs were prepared from RA and healthy synovial tissues. The expression of miR-506 was measured by quantitative real time PCR (qRT-PCR). The effects of miR-506 on RA-FLSs proliferation and apoptosis were detected by cell counting Kit-8 and flow cytometry assays, respectively. The determination of TNF-α, IL-6, and IL-1β concentrations in RA-FLSs supernatant were done by ELISA. The levels of miR-506 were detected to be significantly lower in the synovial tissues and FLSs of RA than in the synovial tissues and FLSs of healthy controls. The miR-506 up-regulation in RA-FLSs significantly inhibited the proliferation and promoted cell cycle arrest at the G0/G1 phase. The overexpression of miR-506 induced apoptosis, along with an increase in activities of caspase-3 and -8. A target gene Toll-like receptor 4 (TLR4) under the direct regulation of miR-506 was identified through the luciferase assay, qRT-PCR and western blot analysis. Forced overexpression of TLR4 in the rescue experiments showed that TLR4 effectively reversed the effect on proliferation and apoptosis in miR-506-overexpressing RA-FLSs. Thus, miR-506 may be a potential target for RA prevention and therapy of RA.
L-securinine inhibits cell growth and metastasis of human androgen-independent prostate cancer DU145 cells via regulating mitochondrial and AGTR1/MEK/ERK/STAT3/PAX2 apoptotic pathways
Authors: Zhang Dongxu , Liu Houxian , Yang Binbin , Hu Jiasheng , Cheng Yue
Published: April 2019

The present study aims to evaluate the anticancer effect of L-securinine on androgen-independent prostate cancer (AIPC) DU145 cells. L-securinine (2.5, 5, and 10 μM) treatment for 24, 48 and 72 h displayed strong growth inhibitory effect on DU145 cells in a concentration and time-dependent fashion but has less toxicity toward normal androgen-dependent LNCaP cells. Hoechst 332582 staining of DU145 cells and Annexin V-FITC/ PI dual-labeling followed by flow cytometry assay identified that this growth inhibition by L-securinine would be due to the induction of apoptosis. Moreover Transwell assay revealed that L-securinine significantly inhibited the cell migration/invasion ability of DU145 cells. Furthermore, results of western blotting showed that the involvement of mitochondrial apoptotic pathway in the L-securinine-induced apoptosis of DU145 cell, as evidenced by an increase in the protein expression of Bax, cleaved caspase-9, cleaved caspase-3, cytosolic cytochrome c, and cleaved PARP, together with a unchanged cleaved caspase-8 and decreased Bcl-2 protein expression. Also, L-securinine-induced antimetastatic activity in DU145 cells was associated with decreased protein expression of MMP-2 and MMP-9 and concurrent reduction of VEGF. In addition, further studies revealed that L-securinine may inhibit the protein expression of AGTR1, p-MEK1/2, p-ERK1/2, p-STAT3, PAX2, and p-PAX2, while the expression of ERK1/2, MEK1/2, and STAT3 protein retains intact. These findings suggest that L-securinine may be a promising chemopreventive agent against AIPC.
Towards insider threats detection in smart grid communication systems
Authors: Li Beibei , Lu Rongxing , Xiao Gaoxi , Bao Haiyong , Ghorbani Ali A.
Published: April 2019

In today's communication systems, the most damaging security threats are not originating from the outsiders but from the trusted insiders – both malicious insiders and negligent insiders. Always endowed with high privileges, insiders are significantly prone to conduct acts that can cause catastrophic damages to the whole system either intentionally or unintentionally. Characterised by the full and rapid integration of information and communication technologies, smart grid – arguably the largest national critical engineering infrastructure – is suffering from a multitude of security threats initiated from both outsiders and insiders. Without security guarantee, the promising benefits of achieving an efficient, green, and reliable power grid would not be a success. In this study, the authors investigate the insider threats and summarise the existing threats detection solutions in smart grid communication systems. In addition, a novel hybrid insider threats modelling, analysis, and detection framework, which is based on stochastic Petri net and behaviour rule specifications, is proposed to contain insider threats in smart grid communication systems.
Optimal power allocation functions for a class of relay selection strategies employing multi‐layer coding approach
Authors: Latif Damavandi Sedigheh , Akhlaghi Soroush , Khodam Hoseini Sayed Ali
Published: April 2019

This study investigates the average achievable rate of a two‐hop block‐fading communication channel, where some single antenna relays are situated in the middle of the transmission and make the destination accessible to the transmitter. It is assumed that the transmitter as well as the relays are not aware of their corresponding instantaneous channel state information (CSI). However, a central node has the corresponding CSI of all links and selects the proper relay that best fits the provided selection criteria. By incorporating a multi‐layer coding approach, which is well known to be a state‐of‐the‐art option to deal with the lack of CSI at the transmitter, the power allocation among the code layers are derived at the transmitter as well as the selected relay node, and the effect of incorporating the aforementioned coding approach in conjunction with the provided relay selection strategies are studied. The results are also compared with that of the single‐layer coding which is being served as a benchmark in this study.
Traitement du carcinome hépatocellulaire avancé : une deuxième révolution avec l’immunothérapie
Authors: Fartoux Laetitia , Rosmorduc Olivier
Published: April 2019

Le traitement du carcinome hépatocellulaire avancé a été longtemps désespérant en raison de l’absence de molécules efficaces et de la cirrhose sous-jacente, compromettant la tolérance aux chimiothérapies classiques. Une thérapie ciblée anti-angiogénique, le sorafenib, a été la seule option pendant une décennie avant que de nouvelles molécules orales soient enfin validées. L’immunothérapie, destinée à corriger le contexte immunosuppresseur fréquemment associé à cette tumeur, a montré des résultats prometteurs et pourrait remettre en question l’algorithme thérapeutique du carcinome hépatocellulaire avancé.
Wirkung von Aqua-Cycling als Bewegungstherapie bei der
Diagnose Lipödem
Authors: Burger R. , Jung M. , Becker J. , Krominus J. , Lampe M. , Kleinschmidt J. , Kleinschmidt B.
Published: April 2019

In der folgenden Übersicht werden die allgemeinen Vorteile von
Bewegungsinterventionen im Wasser innerhalb der physikalischen
Therapiemöglichkeiten sowie bei den Diagnosen Lip- und Lymphödem angesprochen.
Aufgrund von positiven Erfahrungen bei Lymphödempatientinnen werden hier
Einzelfallkasuistiken bzgl. des Einsatzes von Aqua-Cycling bei Lipödem
vorgestellt, die weitere Untersuchungen anstoßen sollten.
Effects of Enantiomerically Pure β-Carboline Alkaloids from Picrasma quassioides on Human Hepatoma Cells
Authors: Zhao Wen-Yu , Chen Jing-Jie , Zou Chun-Xin , Zhou Wei-Yu , Yao Guo-Dong , Wang Xiao-Bo , Lin Bin , Huang Xiao-Xiao , Song Shao-Jiang
Published: April 2019

Four pairs of β-carboline enantiomers (1a/1b–4a/4b), 2 β-carboline derivatives (5 – 6) with a single enantiomeric configuration, together with 2 known achiral congeners (7 – 8) were isolated from the stems of Picrasma quassioides. Their structures were elucidated on the basis of extensive spectroscopic analyses and quantum mechanical calculations. Compound 5 possesses a 4,5-seco β-carboline framework and represents the first example of this type of β-carboline alkaloids from nature. A possible biosynthetic pathway is proposed to generate the racemate 4 and the enantiomerically pure compounds 5 and 6. All isolates were screened for their cytotoxicity against hepatocellular carcinoma Hep3B and HepG2 cells, which revealed that enantiomeric compounds 4a and 4b had distinctive effects in HepG2 cells. Further investigation showed that 4b could induce apoptosis in HepG2 cells.
Digitale Pflegedokumentation: Kliniken Nordoberpfalz und RECOM-GRIPS: Eine 10-jährige Erfolgsgeschichte
Authors: Kaboli Patrick Afschar
Published: April 2019

Seit 2008 arbeitet man am Hauptstandort in Weiden mit RECOMs Patientenakte. Ausschlaggebend für die Entscheidung zur Digitalisierung waren steigende Dokumentationsanforderungen wegen gesetzlicher Vorgaben und höheren Pflegeaufwandes. Wichtiger noch: die Steigerung der Pflegequalität.
Digitale Patienteninformation: Doppelte Kompetenz für den digitalen Wandel
Authors: Gärisch André
Published: April 2019

Thieme und m.Doc schlagen ein wegweisendes Kapitel im patientenorientierten Informationsmanagement auf. Durch die integrierte Partnerlösung gelingt es dem Patienten einfacher denn je, zeit- und ortsunabhängig relevante Inhalte und Services aufzurufen.
Digitale Dokumentation und Archivierung: Den digitalen Traum gemeinsam denken
Authors: Gärisch André
Published: April 2019

Für eine spürbar effiziente Digitalisierung ist entscheidend, relevante Arbeitsabläufe zu identifizieren und aus diesen Potentialen innovative Lösungen zu entwickeln.
Atomic-layer-deposited HfO2/Al2O3 laminated dielectrics for bendable Si nanomembrane based MOS capacitors
Authors: Liu Chen , Wang Zhuofan , Lu Hongliang , Zhang Yuming , Liu Dong , Zhang Yi-Men , Ma Zhenqiang , Zhao Jing , Guo Lixin , Xiong Kanglin
Published: April 2019

Flexible metal-oxide-semiconductor capacitors in a vertical structure using the single-crystalline Si nanomembrane (NM) with a HfO2/Al2O3 bilayer gate stack prepared by atomic layer deposition have been fabricated on plastic substrates by flip-transfer printing of Si NM/Ti/Au based trilayer heterostructures (1.3 cm × 0.9 cm × 360 nm). The electrical properties of the bilayer structure exhibit an excellent improved capacitance-voltage (C-V) frequency dispersion feature associated with an inhibited weak inversion hump and significantly larger accumulation capacitance, thus indicating the effectiveness of the passivation utilizing bilayer high-k dielectrics on a Si NM channel compared with monolayer HfO2. A comprehensive electromechanical characterization has been conducted for HfO2/Al2O3 stacked structures to investigate the effect of bending strain on C-V characteristics, leakage current density, and the associated evolution of interface charges. The presented research will be beneficial to realizing high performance thin-film transistors with lower operating voltage and higher driving current required in emerging flexible and stretchable electronics via optimized design of a nanolaminate gate stack and understanding the impact of mechanical strains on the electrical behavior of such MOS devices.
Photoemission driven electron two-stream instability (ETSI) and evolution of plasma sheath
Authors: Changmai Suniti , Bora Madhurjya P.
Published: April 2019

Analysis related to the onset and evolution of the electron two-stream instability (ETSI) near a surface with a continuous photoemission flux is presented. With the help of a particle-in-cell simulation code, it is shown that when a surface emits photoelectrons due to exposure to ultraviolet photons (or due to similar mechanisms), it may lead to the onset of the ETSI due to the relative bulk velocity difference between the photoelectrons and the plasma electrons. It is shown that the ETSI thus developed is sustained through the lifetime of the plasma and prevents thermalization of the electrons, which leads to a distortion in the electron velocity distribution function (EVDF) resulting a high energy tail, at least near the surface. We have shown that the resultant EVDF can be highly Lorentzian with a spectral index of ∼1.5. The simulation results are supported with the corresponding theory, which are found to be in good agreement.
Bayesian modeling of microwave radiometer calibration on the example of the Wendelstein 7-X electron cyclotron emission diagnostic
Authors: Hoefel Udo , Hirsch Matthias , Kwak Sehyun , Pavone Andrea , Svensson Jakob , Stange Torsten , Hartfuß Hans-Jürgen , Schilling Jonathan , Weir Gavin , Oosterbeek Johan Willem , Bozhenkov Sergey , Braune Harald , Brunner Kai-Jakob , Chaudhary Neha , Damm Hannes , Fuchert Golo , Knauer Jens , Laqua Heinrich , Marsen Stefan , Moseev Dmitry , Pasch Ekkehard , Scott Evan R. , Wilde Fabian , Wolf Robert ,   W7-X Team
Published: April 2019

This paper reports about a novel approach to the absolute intensity calibration of an electron cyclotron emission (ECE) spectroscopy system. Typically, an ECE radiometer consists of tens of separated frequency channels corresponding to different plasma locations. An absolute calibration of the overall diagnostic including near plasma optics and transmission line is achieved with blackbody sources at LN2 temperature and room temperature via a hot/cold calibration mirror unit. As the thermal emission of the calibration source is typically a few thousand times lower than the receiver noise temperature, coherent averaging over several hours is required to get a sufficient signal to noise ratio. A forward model suitable for any radiometer calibration using the hot/cold method and a periodic switch between them has been developed and used to extract the voltage difference between the hot and cold temperature source via Bayesian analysis. In contrast to the classical analysis which evaluates only the reference temperatures, the forward model takes into account intermediate effective temperatures caused by the finite beam width and thus uses all available data optimally. This allows the evaluation of weak channels where a classical analysis would not be feasible, is statistically rigorous, and provides a measurement of the beam width. By using a variance scaling factor, a model sensitive adaptation of the absolute uncertainties can be implemented, which will be used for the combined diagnostic Bayesian modeling analysis.
An atomistic view on the Schottky barrier lowering applied to SrTiO3/Pt contacts
Authors: Funck C. , Menzel S.
Published: April 2019

The interface between a metal and a semiconductor is known as Schottky contact and a key factor in semiconductor technologies. Those interfaces normally build an energetic barrier, which is responsible for the exponential current voltage dependence. Analytical models often describe the right trend for the description of the Schottky barrier height, but fail to predict the barrier properties quantitatively correct. To overcome this problem atomistic and quantum mechanical approaches are required such as the here applied density functional theory combined with the non-equilibrium Greens function method. So far, these methods have rarely been applied to wide band gap metal oxides, which leads to a lack in the understanding of oxide electronics. The presented study deals with the image force induced Schottky barrier lowering of a SrTiO3/Pt interface as a model system for wide band gap metal-oxide Schottky contacts. The Schottky barrier lowering is investigated for the case of different doping concentrations/positions and for different voltages. From a defect chemical point of view, oxygen vacancies act as donors in many metal oxides and dominate the electronic conduction in oxide electronics. Consequently, we investigated the Schottky barrier lowering induced by oxygen vacancies. The second doping mechanism is achieved in the sense of classical doping using Nb impurities, which form a conventional n-type donor. The atomistic simulation reveals the Schottky barrier lowering effect for both type of dopants. The results are compared to a standard analytical model regarding the Schottky barrier lowering.
Characteristics of the dielectric barrier corona discharges
Authors: Yehia Ashraf
Published: April 2019

In this paper, the electrical characteristics of both the dielectric barrier corona discharge and the usual ac corona discharge have been studied in parallel with the ozone generation under the same operating conditions. Therefore, the corona discharges were formed inside two identical reactors in the form of a coaxial wire-to-cylinder with and without a dielectric barrier covering the inner surface of the cylinder. The two reactors have been fed by constant flow rates from the dry air and the oxygen gas independently at the atmospheric pressure and the room temperature, in parallel with applying a sinusoidal ac voltage to the electrodes of the reactors. The electric power consumed in forming the corona discharges and the waveform of the discharge current as well as the ozone concentration generated in the flowing gases through the reactors have been studied versus the peak of the ac voltage that was applied to the reactors. The current-voltage oscillograms showed that the sequence of the dielectric barrier corona discharge modes in both the dry air and the oxygen gas is the same as the sequence of the usual ac corona discharge modes in the same gases. With the increase of the peak value of the ac voltage applied to the dielectric barrier corona discharge reactor, the peak of the discharge current increases linearly while the value of the electric charge accumulated on the surface of the dielectric barrier increases in the form of a power function. The ozone concentration generated by the dielectric barrier corona discharges is approximately equal to the ozone concentration generated by the usual ac corona discharges in both the dry air and the oxygen gas under the same operating conditions.
Water in hybrid perovskites: Bulk MAPbI3 degradation via super-hydrous state
Authors: Kakekhani Arvin , Katti Radhika N. , Rappe Andrew M.
Published: April 2019

Here, first-principles density functional theory calculations are presented which reveal how water incorporation in hybrid halide perovskite [CH3NH3]PbI3 (MAPbI3) catalyzes the phase transition to the ([CH3NH3]PbI3.H2O edge-sharing) monohydrate (colorless) phase, eliminating its favorable photovoltaic properties. First, fundamental chemical and electrostatic interactions between water and each component of MAPbI3 are analyzed, demonstrating their dependence on water concentration. Second, the energetics of incorporated water is explored, leading to the discovery of spontaneous phase segregation into dry regions and regions with more than one water per formula unit—termed the “super-hydrous state.” Third, the properties of the super-hydrous state are analyzed, including the acceleration of octahedron breaking and rearrangement by the high water density. This reveals the phase transformation to be a bulk process, initiated at the super-hydrous regions. This paper concludes with a discussion of how this super-hydrous model explains disparate recent experimental observations concerning the water-induced transition from (black) perovskite to edge-sharing PbI2 (yellow) phase.
Topological implications of the total generalized electron-flow magnetic helicity invariant in electron magnetohydrodynamics
Authors: Shivamoggi B. K. , Michalak M.
Published: April 2019

Topological implications of the total generalized electron-flow magnetic helicity He in electron magnetohydrodynamics (EMHD) are explored. The invariance of He is shown to imply the invariance of the sum of the linkage of magnetic field lines, the linkage of electron-flow vorticity field lines, and the mutual linkage among these two sets of field lines. This result appears to support a change in the magnetic field topology and hence paves the way for magnetic reconnection in EMHD via a change in the concomitant electron-flow vorticity topology.
Friction and wear properties of base oil enhanced by different forms of reduced graphene
Authors: Patel Jankhan , Pereira Gavin , Irvine Doug , Kiani Amirkianoosh
Published: April 2019

In this study, the tribological effects of three different forms of reduced graphene oxide (rGO)-2D nano-additives in base oil were investigated. Reduced graphene oxide nanoplatelets were manufactured using a modified Hummers’ method. However, different filtration methods were used to obtain rGO nanoplatelets at three different bulk densities. After adding nano-additives to the base oil at 0.01%w/w concentration, physical and chemical characterization tests were performed such as viscosity test, four-ball wear test, rotating pressure vessel oxidation test (RPVOT), resistivity test and friction coefficient test. The presented results show that material-1 with the lowest bulk density and less lattice defect can perform better by reducing wear of the material by 10.63% as well as the coefficient of friction (COF) by 6.3% with respect to the base oil and under test conditions. The presented results show the promising effect of rGO as nano-additives to fluid lubricants on wear preventive properties without compromising the physical and chemical characteristics of the lubricants.
Electrical resistivity under pressure and thermal expansion of LaPt2Si2 single crystal
Authors: Gupta Ritu , Thamizhavel A. , Rodière P. , Nandi S. , Rajeev K. P. , Hossain Z.
Published: April 2019

We have performed electrical transport under pressure and thermal expansion measurements on a LaPt2Si2 single crystal. The charge density wave (CDW) transition temperature TCDW decreases, while the superconducting transition temperature TC increases with the application of pressure, which confirms the competing nature of the two phases. We present an attempt to understand the pressure (P) dependence of TCDW within the framework of the mean field theory. A well defined anomaly in temperature-dependent relative thermal expansion (ΔL/L0) and the linear thermal expansion coefficient (αa) has been observed around TCDW associated with the structural transformation accompanied by a CDW transition.
Explosive synchronization in frequency displaced multiplex networks
Authors: Jalan Sarika , Kumar Anil , Leyva Inmaculada
Published: April 2019

Motivated by the recent multiplex framework of complex networks, in this work, we investigate if explosive synchronization can be induced in the multiplex network of two layers. Using nonidentical Kuramoto oscillators, we show that a sufficient frequency mismatch between two layers of a multiplex network can lead to explosive inter- and intralayer synchronization due to mutual frustration in the completion of the synchronization processes of the layers, generating a hybrid transition without imposing any specific structure-dynamics correlation.
Strain sensitivity and symmetry of 2.65 eV color center in diamond nanoscale needles
Authors: Venturi L. , Rigutti L. , Houard J. , Blum I. , Malykhin S. , Obraztsov A. , Vella A.
Published: April 2019

Color centers in diamond have unique applications as nanoscale field sensors. In particular, in the case of strain field, they are key components for the realization of strain-coupled hybrid spin-oscillator systems. Here, we report on the strain sensitivity of the color center emitting at 2.65 eV in diamond nanoscale needles. By contactless piezo-spectroscopy, we compare the strain sensitivity of this center with that of the well-known neutral nitrogen-vacancy (NV0) center. We demonstrate that the 2.65 eV center has a higher strain sensitivity than the NV0 center and can be explored as a strain sensor and/or for strain-coupled systems. Moreover, we perform polarization-resolved photoluminescence spectroscopy under a high uniaxial tensile stress and the polar behavior reported for the 2.65 eV center points out to a defect symmetry which is different from that of the NV0 center.
Design methodology of a frequency up-converting energy harvester based on dual-cantilever and pendulum structures
Authors: Wu Yipeng , Qiu Jinhao , Kojima Fumio , Ji Hongli , Xie Weitai , Zhou Shengpeng
Published: April 2019

Mechanical frequency up-conversion is a technique whereby a high-frequency oscillation is induced from a low-frequency source and aims to address inherent problems in low frequency vibration energy harvesting. This work presents a novel 1:2:6 internal resonances based frequency up-converting harvester in which the operation frequency is 6 times up-converted. Compared to traditional conceptual mechanisms (e.g. mechanical impact, mechanical plucking, impulsive acceleration), the proposed harvester can operate at much lower acceleration level, the missing of sound during the frequency conversion also reduces the energy consumption. Experimental measurements and theoretical simulations demonstrate that the proposed design can collect energy from ultra-low frequency (< 5 Hz) vibration sources. In addition, the harvester shows very high performance compared to the current state-of-the-art devices, a maximum 2.07 mW of average power is obtained from the fabricated prototype at the excitation frequency and level of 1.71 Hz & 0.19 g, respectively.
Dispersion forces in nanoscience
Authors: Rusanov Anatoly I. , Brodskaya Elena N.
Published: April 2019

The 21st century was marked by a new outbreak of interest in dispersion forces in nanoscale systems. However, now the consideration is conducted at a different level. Whereas earlier the main object of study was infinite plane-parallel films, now it is a question of calculations for systems of a more complex configuration with non-parallel and finite surfaces of various shapes. On the other hand, it is not the average interaction force that is estimated, but the detailed mechanical state of the interacting bodies, for which statistical mechanics and the Irving – Kirkwood stress tensor are involved. This review summarizes the theoretical studies of plane-parallel, but finite-area films, wedge-shaped films, systems with spherical, cylindrical, and conical surfaces. Particular consideration is given to interactions involving nanoparticles. Spheroidal particles, rod-like and disc-shaped particles are analyzed. The shape factor of the interaction of particles with a flat surface is estimated. The calculation of the contribution of dispersion forces to surface, line and point tension is explained. Among the latest news is the calculation (brought to numbers) of the contribution of dispersion forces to the graphene point energy.

The bibliography includes 109 references.
Metal complex catalysis in the chemistry of lower diamondoids
Authors: Khusnutdinov Ravil I. , Shchadneva Nina A.
Published: April 2019

The review presents the first survey of published data on the use of compounds, complexes and nanoparticles of transition metals (Fe, Co, Ni, Mn, V, Mo, Cu, Pd, Pt, Rh, Ru, Os, Au, Re and Th) in the catalytic transformations of lower diamondoids — adamantane, diamantane and their derivatives. Catalytic halogenation, oxidation, alkylation and cross-coupling reactions are considered, and the formation pathways of C–N, C–S and C–Se bonds in the series of adamantanoids are discussed. Reaction conditions, appropriate catalytic systems and the structures of products are presented.

The bibliography includes 242 references.
Assessing the diet and trophic niche breadth of an omnivorous fish (Glanidium ribeiroi) in subtropical lotic environments: intraspecific and ontogenic responses to spatial variations
Authors: Kliemann B. C. K. , Baldasso M. C. , Pini S. F. R. , Makrakis M. C. , Makrakis S. , Delariva R. L.
Published: April 2019

The diet of Glanidium ribeiroi was investigated in lotic stretches downstream from a cascade of reservoirs to determine how it responds to intraspecific and environmental variations. Monthly sampling was performed from 2013 to 2016 at sites including the main channel of the Iguaçu River and tributaries in preserved basins and agricultural land. The diet of individuals in the preserved tributaries was primarily associated with allochthonous resources, whereas in the non-preserved tributaries and main channel the diets were primarily associated with autochthonous resources. Trophic niche breadth and intraspecific variability differed significantly among sampling areas and size classes. Trophic niche overlap among size classes and sampling areas was low. Positive and negative relationships between the trophic niche breadth and the standard length of individuals were also found in different sampling areas. Intraspecific and ontogenic variations were strongly and consistently associated with forest cover. Individuals responded differently to local environmental variations due to differences in landscape gradients and life cycle changes. Therefore, the effects of spatial heterogeneity on diet composition and intraspecific variations therein appear to be crucial to the success of the populations evaluated. These results may help with the implementation of conservation measures for this and other endemic species.
Stabilization of amyloidogenic immunoglobulin light chains by small molecules
Authors: Morgan Gareth J. , Yan Nicholas L. , Mortenson David E. , Rennella Enrico , Blundon Joshua M. , Gwin Ryan M. , Lin Chung-Yon , Stanfield Robyn L. , Brown Steven J. , Rosen Hugh , Spicer Timothy P. , Fernandez-Vega Virneliz , Merlini Giampaolo , Kay Lewis E. , Wilson Ian A. , Kelly Jeffery W.
Published: April 2019

In Ig light-chain (LC) amyloidosis (AL), the unique antibody LC protein that is secreted by monoclonal plasma cells in each patient misfolds and/or aggregates, a process leading to organ degeneration. As a step toward developing treatments for AL patients with substantial cardiac involvement who have difficulty tolerating existing chemotherapy regimens, we introduce small-molecule kinetic stabilizers of the native dimeric structure of full-length LCs, which can slow or stop the amyloidogenicity cascade at its origin. A protease-coupled fluorescence polarization-based high-throughput screen was employed to identify small molecules that kinetically stabilize LCs. NMR and X-ray crystallographic data demonstrate that at least one structural family of hits bind at the LC–LC dimerization interface within full-length LCs, utilizing variable-domain residues that are highly conserved in most AL patients. Stopping the amyloidogenesis cascade at the beginning is a proven strategy to ameliorate postmitotic tissue degeneration.
TePhe, a tellurium-containing phenylalanine mimic, allows monitoring of protein synthesis in vivo with mass cytometry
Authors: Bassan Jay , Willis Lisa M. , Vellanki Ravi N. , Nguyen Alan , Edgar Landon J. , Wouters Bradly G. , Nitz Mark
Published: April 2019

Protein synthesis is central to maintaining cellular homeostasis and its study is critical to understanding the function and dysfunction of eukaryotic systems. Here we report L-2-tellurienylalanine (TePhe) as a noncanonical amino acid for direct measurement of protein synthesis. TePhe is synthetically accessible, nontoxic, stable under biological conditions, and the tellurium atom allows its direct detection with mass cytometry, without postexperiment labeling. TePhe labeling is competitive with phenylalanine but not other large and aromatic amino acids, demonstrating its molecular specificity as a phenylalanine mimic; labeling is also abrogated in vitro and in vivo by the protein synthesis inhibitor cycloheximide, validating TePhe as a translation reporter. In vivo, imaging mass cytometry with TePhe visualizes translation dynamics in the mouse gut, brain, and tumor. The strong performance of TePhe as a probe for protein synthesis, coupled with the operational simplicity of its use, suggests TePhe could become a broadly applied molecule for measuring translation in vitro and in vivo.