bluuebunny/crossref_metadata_2025 huggingface dataset:
Distribution of Rare Earth Elements plus Yttrium among Major Mineral Phases of Marine Fe–Mn Crusts from the South China Sea and Western Pacific Ocean: A Comparative Study
Authors: Ren Yingzhi , Sun Xiaoming , Guan Yao , Xiao Zhenglian , Liu Ying , Liao Jianlin , Guo Zhengxing
Published: December 2018

Marine hydrogenetic Fe–Mn crusts on seamounts are known as potential mineral resources of rare earth elements plus yttrium (REY). In recent years, increasing numbers of deposits of Fe–Mn crusts and nodules were discovered in the South China Sea (SCS), yet the enrichment mechanism of REY is yet to be sufficiently addressed. In this study, hydrogenetic Fe–Mn crusts from the South China Sea (SCS) and the Western Pacific Ocean (WPO) were comparatively studied with mineralogy and geochemistry. In addition, we used an in situ REY distribution mapping method, implementing laser ablation inductively coupled plasma mass spectrometry (LA-ICP-MS) and a sequential leaching procedure to investigate the partitioning behavior of REY in the Fe–Mn crusts. The typical Fe–Mn crusts from SCS were mainly composed of quartz, calcite, vernadite (δ-MnO2), and amorphous Fe oxides/hydroxides (FeOOH). The Fe–Mn crusts from the Central SCS Basin and the WPO contained quartz, δ-MnO2, FeOOH, todorokite, and phillipsite. Furthermore, geochemical analysis indicated that the typical SCS crusts had a higher growth rate and lower REY concentrations. The LA-ICP-MS mapping results showed that the δ-MnO2 and FeOOH dominated the occurrence phases of REY in the SCS crusts. Four mineral phases (i.e., easily exchangeable and carbonate, Mn-oxide, amorphous FeOOH, and residual aluminosilicates) in these Fe–Mn crusts were separated by a sequential leaching procedure. In the SCS and WPO crusts, the majority of total REY (ΣREY) was distributed in the Mn-oxide and amorphous FeOOH phases. The post-Archean Australian shale-normalized REY patterns showed that light REY (LREY) and heavy REY (HREY) were preferentially adsorbed onto δ-MnO2 and FeOOH, respectively. It is noteworthy that ~27% of ΣREY was associated with the residual aluminosilicates phase of the WPO crusts. The La/Al ratios in the aluminosilicates phase of the typical SCS crusts were the values of the upper crust. We conclude that large amounts of terrigenous materials dilute the abundance of REY in the SCS crusts. In addition, the growth rates of Fe–Mn crusts have a negative correlation with the FeOOH-bound and aluminosilicate-bound REY. As a result of the fast growth rates, the SCS crusts contain relatively low concentrations of REY.
Bioinspired-Metalloporphyrin Magnetic Nanocomposite as a Reusable Catalyst for Synthesis of Diastereomeric (−)-Isopulegol Epoxide: Anticancer Activity Against Human Osteosarcoma Cells (MG-63)
Authors: Dias Lucas D. , Batista de Carvalho Ana L. M. , Pinto Sara M. A. , Aquino Gilberto L. B. , Calvete Mário J. F. , Rossi Liane M. , Marques M. P. M. , Pereira Mariette M.
Published: December 2018

In the present study, we developed a green epoxidation approach for the synthesis of the diastereomers of (−)-isopulegol benzyl ether epoxide using molecular oxygen as the oxidant and a hybrid manganese(III)-porphyrin magnetic reusable nanocomposite as the catalyst. High activity, selectivity, and stability were obtained, with up to four recycling cycles without the loss of activity and selectivity for epoxide. The anticancer effect of the newly synthesized isopulegol epoxide diastereomers was evaluated on a human osteosarcoma cell line (MG-63); both diastereomers showed similar in vitro potency. The measured IC50 values were significantly lower than those reported for other monoterpene analogues, rendering these epoxide isomers as promising anti-tumor agents against low prognosis osteosarcoma.
Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates
Authors: Ivanova Olga A. , Andronov Vladimir A. , Levina Irina I. , Chagarovskiy Alexey O. , Voskressensky Leonid G. , Trushkov Igor V.
Published: December 2018

A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.
Dermal Delivery of Selected Polyphenols from Silybum marianum. Theoretical and Experimental Study
Authors: Kosina Pavel , Paloncýová Markéta , Rajnochová Svobodová Alena , Zálešák Bohumil , Biedermann David , Ulrichová Jitka , Vostálová Jitka
Published: December 2018

Silymarin is a well-known standardized extract from the seeds of milk thistle (Silybum marianum L., Asteraceae) with a pleiotropic effect on human health, including skin anticancer potential. Detailed characterization of flavonolignans properties affecting interactions with human skin was of interest. The partition coefficients log Pow of main constitutive flavonolignans, taxifolin and their respective dehydro derivatives were determined by a High Performance Liquid Chromatography (HPLC) method and by mathematical (in silico) approaches in n-octanol/water and model lipid membranes. These parameters were compared with human skin intake ex vivo. The experimental log Pow values for individual diastereomers were estimated for the first time. The replacement of n-octanol with model lipid membranes in the theoretical lipophilicity estimation improved the prediction strength. During transdermal transport, all the studied compounds permeated the human skin ex vivo; none of them reached the acceptor liquid. Both experimental/theoretical tools allowed the studied polyphenols to be divided into two groups: low (taxifolin, silychristin, silydianin) vs. high (silybin, dehydrosilybin, isosilybin) lipophilicity and skin intake. In silico predictions can be usefully applied for estimating general lipophilicity trends, such as skin penetration or accumulation predictions. However, the theoretical models cannot yet provide the dermal delivery differences of compounds with very similar physico-chemical properties; e.g., between diastereomers.
Impact of Quantum Dot Surface on Complex Formation with Chlorin e6 and Photodynamic Therapy
Authors: Skripka Artiom , Dapkute Dominyka , Valanciunaite Jurga , Karabanovas Vitalijus , Rotomskis Ricardas
Published: December 2018

Nanomaterials have permeated various fields of scientific research, including that of biomedicine, as alternatives for disease diagnosis and therapy. Among different structures, quantum dots (QDs) have distinctive physico-chemical properties sought after in cancer research and eradication. Within the context of cancer therapy, QDs serve the role of transporters and energy donors to photodynamic therapy (PDT) drugs, extending the applicability and efficiency of classic PDT. In contrast to conventional PDT agents, QDs’ surface can be designed to promote cellular targeting and internalization, while their spectral properties enable better light harvesting and deep-tissue use. Here, we investigate the possibility of complex formation between different amphiphilic coating bearing QDs and photosensitizer chlorin e6 (Ce6). We show that complex formation dynamics are dependent on the type of coating—phospholipids or amphiphilic polymers—as well as on the surface charge of QDs. Förster’s resonant energy transfer occurred in every complex studied, confirming the possibility of indirect Ce6 excitation. Nonetheless, in vitro PDT activity was restricted only to negative charge bearing QD-Ce6 complexes, correlating with better accumulation in cancer cells. Overall, these findings help to better design such and similar complexes, as gained insights can be straightforwardly translated to other types of nanostructures—expanding the palette of possible therapeutic agents for cancer therapy.
Facile Preparation of Rod-like MnO Nanomixtures via Hydrothermal Approach and Highly Efficient Removal of Methylene Blue for Wastewater Treatment
Authors: Xu Yuelong , Ren Bin , Wang Ran , Zhang Lihui , Jiao Tifeng , Liu Zhenfa
Published: December 2018

In the present study, nanoscale rod-shaped manganese oxide (MnO) mixtures were successfully prepared from graphitic carbon nitride (C3N4) and potassium permanganate (KMnO4) through a hydrothermal method. The as-prepared MnO nanomixtures exhibited high activity in the adsorption and degradation of methylene blue (MB). The as-synthesized products were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), surface area analysis, X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS). Furthermore, the effects of the dose of MnO nanomixtures, pH of the solution, initial concentration of MB, and the temperature of MB removal in dye adsorption and degradation experiments was investigated. The degradation mechanism of MB upon treatment with MnO nanomixtures and H2O2 was studied and discussed. The results showed that a maximum adsorption capacity of 154 mg g−1 was obtained for a 60 mg L−1 MB solution at pH 9.0 and 25 °C, and the highest MB degradation ratio reached 99.8% under the following optimum conditions: 50 mL of MB solution (20 mg L−1) at room temperature and pH ≈ 8.0 with 7 mg of C, N-doped MnO and 0.5 mL of H2O2.
Pd-Functionalized SnO2 Nanofibers Prepared by Shaddock Peels as Bio-Templates for High Gas Sensing Performance toward Butane
Authors: Zhao Rongjun , Wang Zhezhe , Yang Yue , Xing Xinxin , Zou Tong , Wang Zidong , Hong Ping , Peng Sijia , Wang Yude
Published: December 2018

Pd-functionalized one-dimensional (1D) SnO2 nanostructures were synthesized via a facile hydrothermal method and shaddock peels were used as bio-templates to induce a 1D-fiber-like morphology into the gas sensing materials. The gas-sensing performances of sensors based on different ratios of Pd-functionalized SnO2 composites were measured. All results indicate that the sensor based on 5 mol % Pd-functionalized SnO2 composites exhibited significantly enhanced gas-sensing performances toward butane. With regard to pure SnO2, enhanced levels of gas response and selectivity were observed. With 5 mol % Pd-functionalized SnO2 composites, detection limits as low as 10 ppm with responses of 1.38 ± 0.26 were attained. Additionally, the sensor exhibited rapid response/recovery times (3.20/6.28 s) at 3000 ppm butane, good repeatability and long-term stability, demonstrating their potential in practical applications. The excellent gas-sensing performances are attributed to the unique one-dimensional morphology and the large internal surface area of sensing materials afforded using bio-templates, which provide more active sites for the reaction between butane molecules and adsorbed oxygen ions. The catalysis and “spillover effect” of Pd nanoparticles also play an important role in the sensing of butane gas as further discussed in the paper.
The Preparation and Properties of Nanocomposite from Bio-Based Polyurethane and Graphene Oxide for Gas Separation
Authors: Zhang Yongsheng , Ma Jun , Bai Yao , Wen Youwei , Zhao Na , Zhang Xiaoling , Zhang Yatao , Li Qian , Wei Liuhe
Published: December 2018

Petroleum depletion and climate change have inspired research on bio-based polymers and CO2 capture. Tung-oil-based polyols were applied to partially replace polyether-type polyols from petroleum for sustainable polyurethane. Tung-oil-based polyurethane (TBPU), was prepared via a two-step polycondensation, that is, bulk prepolymerization and chain extension reaction. The graphene oxide (GO) was prepared via Hummer’s method. Then, TBPU was composited with the GO at different ratios to form a TBPU/GO hybrid film. The GO/TBPU films were characterized by fourier transform infrared spectroscopy (FTIR), differential scanning calorimeter (DSC), thermal gravimetric analysis (TGA) and scanning electron microscope (SEM), followed by the measurement of mechanical properties and gas permeability. The results showed that the addition of tung-oil-based polyols enhanced the glass transition temperature and thermal stability of TBPU. The mechanical properties of the hybrid film were significantly improved, and the tensile strength and elongation at break were twice as high as those of the bulk TBPU film. When the GO content was higher than 2.0%, a brittle fracture appeared in the cross section of hybrid film. The increase of GO content in hybrid films improved the selectivity of CO2/N2 separation. When the GO content was higher than 0.35%, the resulting GO agglomeration constrained the gas separation and permeation properties.
Application of Self-Assembled Raman Spectrum-Enhanced Substrate in Detection of Dissolved Furfural in Insulating Oil
Authors: Shi Haiyang , Chen Weigen , Wan Fu , Du Lingling , Zhang Shuhua , Zhou Weiran , Zhang Jiayi , Huang Yingzhou , Zhu Chengzhi
Published: December 2018

Accurate detection of dissolved aging features in transformer oil is the key to judging the aging degree of oil-paper insulation. In this work, in order to realize in situ detection of furfural dissolved in transformer oil, silver nanoparticles were self-assembled on the surface of gold film with P-aminophenylthiophenol (PATP) as a coupling agent. Rhodamine-6G (R6G) was used as the probe molecule to test the enhancement effect. By optimizing the molecular concentration, molecular deposition time, and silver sol deposition time of PATP, the nanoparticles were made more uniform and compact, and an enhanced substrate with rich hot spots was obtained. The optimum substrate was developed, and surface-enhanced Raman spectroscopy (SERS) detection of trace furfural dissolved in transformer oil was realized. The results showed that the substrate prepared under the conditions of 0.1 mol/L PATP, 5 h deposition in PATP and 12 h immersion in silver sol, had the best reinforcement effect (that is, uniform and compact particle arrangement and no particle clusters). By use of this substrate, the minimum detectable concentration of furfural in transformer oil was about 1.06 mg/L, which provides a new method for fast and nondestructive detection of transformer aging diagnosis.
On the Operational Aspects of Measuring Nanoparticle Sizes
Authors: Teulon Jean-Marie , Godon Christian , Chantalat Louis , Moriscot Christine , Cambedouzou Julien , Odorico Michael , Ravaux Johann , Podor Renaud , Gerdil Adèle , Habert Aurélie , Herlin-Boime Nathalie , Chen Shu-wen , Pellequer Jean-Luc
Published: December 2018

Nanoparticles are defined as elementary particles with a size between 1 and 100 nm for at least 50% (in number). They can be made from natural materials, or manufactured. Due to their small sizes, novel toxicological issues are raised and thus determining the accurate size of these nanoparticles is a major challenge. In this study, we performed an intercomparison experiment with the goal to measure sizes of several nanoparticles, in a first step, calibrated beads and monodispersed SiO2 Ludox®, and, in a second step, nanoparticles (NPs) of toxicological interest, such as Silver NM-300 K and PVP-coated Ag NPs, Titanium dioxide A12, P25(Degussa), and E171(A), using commonly available laboratory techniques such as transmission electron microscopy, scanning electron microscopy, small-angle X-ray scattering, dynamic light scattering, wet scanning transmission electron microscopy (and its dry state, STEM) and atomic force microscopy. With monomodal distributed NPs (polystyrene beads and SiO2 Ludox®), all tested techniques provide a global size value amplitude within 25% from each other, whereas on multimodal distributed NPs (Ag and TiO2) the inter-technique variation in size values reaches 300%. Our results highlight several pitfalls of NP size measurements such as operational aspects, which are unexpected consequences in the choice of experimental protocols. It reinforces the idea that averaging the NP size from different biophysical techniques (and experimental protocols) is more robust than focusing on repetitions of a single technique. Besides, when characterizing a heterogeneous NP in size, a size distribution is more informative than a simple average value. This work emphasizes the need for nanotoxicologists (and regulatory agencies) to test a large panel of different techniques before making a choice for the most appropriate technique(s)/protocol(s) to characterize a peculiar NP.
Systematic Study of the Behavior of Different Metal and Metal-Containing Particles under the Microwave Irradiation and Transformation of Nanoscale and Microscale Morphology
Authors: Pentsak Evgeniy O. , Cherepanova Vera A. , Sinayskiy Mikhail A. , Samokhin Andrey V. , Ananikov Valentine P.
Published: December 2018

In recent years, the application of microwave (MW) irradiation has played an increasingly important role in the synthesis and development of high performance nanoscale catalytic systems. However, the interaction of microwave irradiation with solid catalytic materials and nanosized structures remains a poorly studied topic. In this paper we carried out a systematic study of changes in morphology under the influence of microwave irradiation on nanoscale particles of various metals and composite particles, including oxides, carbides, and neat metal systems. All systems were studied in the native solid form without a solvent added. Intensive absorption of microwave radiation was observed for many samples, which in turn resulted in strong heating of the samples and changes in their chemical structure and morphology. A comparison of two very popular catalytic materials—metal particles (M) and supported metal on carbon (M/C) systems—revealed a principal difference in their behavior under microwave irradiation. The presence of carbon support influences the heating mechanism; the interaction of substances with the support during the heating is largely determined by heat transfer from the carbon. Etching of the carbon surface, involving the formation of trenches and pits on the surface of the carbon support, were observed for various types of the investigated nanoparticles.
MoO3-Doped MnCo2O4 Microspheres Consisting of Nanosheets: An Inexpensive Nanostructured Catalyst to Hydrolyze Ammonia Borane for Hydrogen Generation
Authors: Lu Dongsheng , Feng Yufa , Ding Zitian , Liao Jinyun , Zhang Xibin , Liu Hui-Ru , Li Hao
Published: December 2018

Production of hydrogen by catalytically hydrolyzing ammonia borane (AB) has attracted extensive attention in the field of catalysis and energy. However, it is still a challenge to develop a both inexpensive and active catalyst for AB hydrolysis. In this work, we designed a series of MoO3-doped MnCo2O4 (x) catalysts, which were fabricated by a hydrothermal process. The morphology, crystalline structure, and chemical components of the catalysts were systematically analyzed. The catalytic behavior of the catalyst in AB hydrolysis was investigated. Among these catalysts, MoO3-doped MnCo2O4 (0.10) microspheres composed of nanosheets exhibited the highest catalytic activity. The apparent activation energy is 34.24 kJ mol−1 and the corresponding turnover frequency is 26.4 molhydrogen min−1 molcat−1. Taking into consideration the low cost and high performance, the MoO3-doped MnCo2O4 (0.10) microspheres composed of nanosheets represent a promising catalyst to hydrolyze AB for hydrogen production.
Wave Propagation of Porous Nanoshells
Authors: Karami Behrouz , Shahsavari Davood , Janghorban Maziar , Dimitri Rossana , Tornabene Francesco
Published: December 2018

This study aims at investigating the wave propagation of porous nanoshells. The Bi-Helmholtz non-local strain gradient theory is employed in conjunction with a higher-order shear deformation shell theory, in order to include the size-dependent effects. The nanoshells are made of a porous functionally graded material (P-FGM), whose properties vary continuously along the thickness direction. A variational approach is here applied to handle the governing equations of the problem, which are solved analytically to compute the wave frequencies and phase velocities as function of the wave numbers. The sensitivity of the wave response is analyzed for a varying porosity volume fraction, material properties, non-local parameters, strain gradient length scales, temperature, humidity, and wave numbers. Based on the results, it is verified that the size-dependence of the response is almost the same to the one of plates, beams and tubes.
Muscle Fitness to Visceral Fat Ratio, Metabolic Syndrome and Ideal Cardiovascular Health Metrics
Authors: Ramírez-Vélez Robinson , Correa-Rodríguez María , Izquierdo Mikel , Schmidt-RioValle Jacqueline , González-Jiménez Emilio
Published: December 2018

This study aimed to investigate the association between the muscle fitness to visceral fat level (MVF) ratio and the prevalence of metabolic syndrome (MetS) and ideal cardiovascular health (CVH) metrics among college students. A total of 1467 young adults recruited from the FUPRECOL study (Asociación de la Fuerza Prensil con Manifestaciones Tempranas de Riesgo Cardiovascular en Jóvenes y Adultos Colombianos), were categorized into four quartiles based on their MVF ratio. Muscular fitness was assessed using a digital handgrip dynamometer and visceral fat level was determined through bioelectrical impedance analysis. Ideal CVH was assessed, including lifestyle characteristics, anthropometry, blood pressure, and biochemical parameters. The body weight, waist circumference, body mass index (BMI), fat mass, fat mass index, and visceral fat level were significantly higher in subjects in Q1 (lower MVF ratio) than those in Q2, Q3, or Q4 (p < 0.001). The muscle fitness (handgrip and normalized grip strength (NGS)) of the subjects in Q4 was significantly greater than that of those in Q1 to Q2 (p < 0.001). Subjects with a medium-high MVF ratio (i.e., 3–4th quartiles) had an odds ratio of 2.103 of ideal CVH metrics after adjusting for age, gender, university, and alcohol intake (95% confidence interval (CI) 1.832 to 2.414; p < 0.001). A lower MVF ratio is associated with worse CVH metrics and a higher prevalence of MetS in early adulthood, supporting the hypothesis that the MVF ratio could be used as a complementary screening tool that could help clinicians identify young adults with unfavorable levels of CVH and metabolic risk.
A Hydrolyzed Chicken Extract CMI-168 Enhances Learning and Memory in Middle-Aged Mice
Authors: Tsai Sheng-Feng , Chang Chia-Yuan , Yong Shan-May , Lim Ai-Lin , Nakao Yoshihiro , Chen Shean-Jen , Kuo Yu-Min
Published: December 2018

There has been increasing evidence that consumption of dietary supplements or specific nutrients can influence cognitive processes and emotions. A proprietary chicken meat extraction, Chicken Meat Ingredient-168 (CMI-168), has previously been shown to enhance cognitive function in humans. However, the mechanism underlying the CMI-168-induced benefits remains unclear. In this study, we investigated the effects of CMI-168 on hippocampal neuroplasticity and memory function in middle-aged (9–12 months old) mice. The mice in the test group (termed the “CMI-168 group”) were fed dietary pellets produced by mixing CMI-168 and normal laboratory mouse chow to provide a daily CMI-168 dose of 150 mg/kg of body weight for 6 weeks. The control mice (termed the “Chow group”) were fed normal laboratory mouse chow pellets. CMI-168 supplementation did not affect the body weight gain, food intake, or exploratory behavior of the mice. In the novel object recognition test, the CMI-168 group showed better hippocampus-related non-spatial memory compared to the control Chow group. However, spatial memory examined by the Morris Water Maze test was similar between the two groups. There was also no significant difference in the induction and maintenance of long-term potentiation and dendritic complexity of the hippocampal cornu ammonis region 1 (CA1) neurons, as well as the levels of neuroplasticity-related proteins in the hippocampi of the CMI-168 and Chow groups. Interestingly, we observed that CMI-168 appeared to protect the mice against stress-induced weight loss. In conclusion, dietary supplementation of CMI-168 was found to improve learning and memory in middle-aged mice, independent of structural or functional changes in the hippocampus. The resilience to stress afforded by CMI-168 warrants further investigation.
Navy Beans Impact the Stool Metabolome and Metabolic Pathways for Colon Health in Cancer Survivors
Authors: Baxter Bridget A. , Oppel Renee C. , Ryan Elizabeth P.
Published: December 2018

Colorectal cancer (CRC) is the third leading cause of cancer-related death in the United States and emerging evidence supports that increased consumption of legumes, such as navy beans, can reduce risk. Navy bean consumption was previously shown to modulate host and microbiome metabolism, and this investigation was performed to assess the impact on the human stool metabolome, which includes the presence of navy bean metabolites. This 4-week, randomized-controlled trial with overweight and obese CRC survivors involved consumption of 1 meal and 1 snack daily. The intervention contained 35 g of cooked navy bean or macronutrient matched meals and snacks with 0 g of navy beans for the control group (n = 18). There were 30 statistically significant metabolite differences in the stool of participants that consumed navy bean at day 28 compared to the participants’ baseline (p ≤ 0.05) and 26 significantly different metabolites when compared to the control group. Of the 560 total metabolites identified from the cooked navy beans, there were 237 possible navy bean-derived metabolites that were identified in the stool of participants consuming navy beans, such as N-methylpipecolate, 2-aminoadipate, piperidine, and vanillate. The microbial metabolism of amino acids and fatty acids were also identified in stool after 4 weeks of navy bean intake including cadaverine, hydantoin-5 propionic acid, 4-hydroxyphenylacetate, and caprylate. The stool relative abundance of ophthalmate increased 5.25-fold for navy bean consumers that can indicate glutathione regulation, and involving cancer control mechanisms such as detoxification of xenobiotics, antioxidant defense, proliferation, and apoptosis. Metabolic pathways involving lysine, and phytochemicals were also modulated by navy bean intake in CRC survivors. These metabolites and metabolic pathways represent an acute response to increased navy bean intake, which merit further investigation for improving colonic health after long-term consumption.
Health Status of Female and Male Vegetarian and Vegan Endurance Runners Compared to Omnivores—Results from the NURMI Study (Step 2)
Authors: Wirnitzer Katharina , Boldt Patrick , Lechleitner Christoph , Wirnitzer Gerold , Leitzmann Claus , Rosemann Thomas , Knechtle Beat
Published: December 2018

Health effects of vegetarian and vegan diets are well known. However, data is sparse in terms of their appropriateness for the special nutritional demands of endurance runners. Therefore, the aim of this study was to investigate the health status of vegetarian (VER) and vegan endurance runners (VGR) and compare it to omnivorous endurance runners (OR). A total of 245 female and male recreational runners completed an online survey. Health status was assessed by measuring health-related indicators (body weight, mental health, chronic diseases, and hypersensitivity reactions, medication intake) and health-related behavior (smoking habits, supplement intake, food choice, healthcare utilization). Data analysis was performed by using non-parametric ANOVA and MANOVA. There were 109 OR, 45 VER and 91 VGR. Significant differences (p < 0.05) were determined for the following findings: (i) body weight for VER and VGR was less than for OR, (ii) VGR had highest food choice scores, and (iii) VGR reported the lowest prevalences of allergies. There was no association (p > 0.05) between diet and mental health, medication intake, smoking habits, supplement intake, and healthcare utilization. These findings support the notion that adhering to vegetarian kinds of diet, in particular to a vegan diet, is associated with a good health status and, thus, at least an equal alternative to an omnivorous diet for endurance runners.
Mediterranean Diet and Motivation in Sport: A Comparative Study Between University Students from Spain and Romania
Authors: Chacón-Cuberos Ramón , Badicu Georgian , Zurita-Ortega Félix , Castro-Sánchez Manuel
Published: December 2018

Background: The Mediterranean Diet (MD) is one of the healthiest dietary models worldwide, being an essential mean of preventing pathologies along with the practice of physical activity. Through a comparative study carried out across different countries, it has been demonstrated how this type of habits vary depending on the geographical context. The aim of this research was to evaluate the adherence to MD and its relationships with motivational climate in sport on a sample of university students from Spain and Romania; Methods: A cross-sectional study was conducted on a sample of university students [specialization: Physical Education (n = 605; 20.71 ± 2.42 years old)], using as main instruments the Mediterranean Diet Quality Index (KIDMED) for students and adolescents and the Perceived Motivational Climate in Sport Questionnaire-2 (PMCSQ-2); Results: It was shown that students from Spain had a high adherence to the MD (6.65 ± 2.63 vs. 5.06 ± 1.31). Spanish university students got higher scores in task-oriented motivational climate (4.03 ± 0.62 vs. 3.11 ± 0.55) while ego-oriented climate was higher in university students from Romania (3.24 ± 0.54 vs. 2.07 ± 0.75). Finally, it was observed that the task-oriented motivational climate was related to a lower adherence to MD in Spanish students (4.49 ± 0.37 vs. 3.98 ± 0.62). In contrast, in Romanian youth, a medium adherence to the MD was associated with higher scores for the ego-oriented motivational climate (3.27 ± 0.53 vs. 3.00 ± 0.54); Conclusions: As main conclusions, it was shown that the students from Spain had a high adherence to the MD. In addition, it has been demonstrated that ego-oriented climates are linked to a better adherence to MD, especially due to the importance of following a proper diet in sport contexts, as demonstrated by young Romanians.
Effects of Consuming Calcium-Rich Foods on the Incidence of Type 2 Diabetes Mellitus
Authors: Jeon Jimin , Jang Jiyoung , Park Kyong
Published: December 2018

The effect of calcium consumption in the prevention of type 2 diabetes mellitus (T2DM) remains controversial, and depends on food calcium sources. This prospective study aimed to evaluate the association between calcium-rich food consumption and T2DM incidence among Korean adults. We analyzed the data of 8574 adults aged 40–69 years, without a history of T2DM, cardiovascular disease, and cancer at the baseline from the Korean Genome and Epidemiology Study. The consumption of calcium-rich foods was assessed using a validated semi-quantitative food frequency questionnaire. T2DM-related data were collected using biennial questionnaires, health examinations, and clinical tests. Hazard ratios (HRs) and 95% confidence intervals (CIs) were calculated using Cox proportional hazards regression models. In the multivariate-adjusted model, yogurt intake was inversely associated with T2DM risk (HR: 0.73; 95% CI: 0.61–0.88 in the fourth quartile as compared to the first quartile). However, the intakes of other calcium-rich foods, including milk and anchovies, were not significantly associated with T2DM risk. Yogurt may provide protective effects against T2DM in Korean adults, owing to the beneficial effects of probiotics. Further prospective large-scale cohort studies should be conducted to validate these findings.
Metabolizable Energy from Cashew Nuts is Less than that Predicted by Atwater Factors
Authors: Baer David J. , Novotny Janet A.
Published: December 2018

Recent studies have demonstrated that the energy provided by several tree nuts is less than that predicted by the Atwater factors, though energy available from cashews has never been assessed. The objective of this study was to evaluate the metabolizable energy in cashew nuts. Eighteen healthy adults were enrolled in a randomized, crossover study with two treatment periods. Subjects were fed a fully controlled base diet for 4 weeks with either no additions or with the addition of 42 g/day (1.5 servings) of cashew nuts, with the final treatment diets being isocaloric. Complete diet collections were analyzed for nitrogen (for protein), fat, energy, and carbohydrate by difference. During the final week of each intervention phase, subjects collected all feces and urine produced, and these were also analyzed for nitrogen (feces and urine), energy (feces and urine), and fat (feces). The resulting data were used to calculate the metabolizable energy of cashews and the digestibility of macronutrients. The average available energy (calorie) content of a 28 g serving of cashew nuts was 137 kcal (±3.4 kcal SEM) and ranged from 105 to 151 kcal. The mean value of 137 kcal/serving is 16% lower (p < 0.0001) than what is typically found on food labels. Digestibility of energy, fat, protein, and carbohydrate was lower for the cashew-containing diet compared to the control diet (92.9% vs. 94.9%, p < 0.0001 for energy; 96.1% vs. 97.8%, p = 0.0009 for fat; 90.1% vs. 91.2%, p = 0.0012 for protein; 92.9% vs. 94.9%, p < 0.0001 for carbohydrate; for the cashew-containing diet vs. the control diet, respectively). In conclusion, cashews provide fewer calories than the values predicted by the Atwater factors, as found on current food labels.
Moderate Protein Restriction in Advanced CKD: A Feasible Option in An Elderly, High-Comorbidity Population. A Stepwise Multiple-Choice System Approach
Authors: Fois Antioco , Chatrenet Antoine , Cataldo Emanuela , Lippi Francoise , Kaniassi Ana , Vigreux Jerome , Froger Ludivine , Mongilardi Elena , Capizzi Irene , Biolcati Marilisa , Versino Elisabetta , Piccoli Giorgina Barbara
Published: December 2018

Background: Protein restriction may retard the need for renal replacement therapy; compliance is considered a barrier, especially in elderly patients. Methods: A feasibility study was conducted in a newly organized unit for advanced kidney disease; three diet options were offered: normalization of protein intake (0.8 g/kg/day of protein); moderate protein restriction (0.6 g/kg/day of protein) with a “traditional” mixed protein diet or with a “plant-based” diet supplemented with ketoacids. Patients with protein energy wasting (PEW), short life expectancy or who refused were excluded. Compliance was estimated by Maroni-Mitch formula and food diary. Results: In November 2017–July 2018, 131 patients started the program: median age 74 years (min–max 24-101), Charlson Index (CCI): 8 (min-max: 2–14); eGFR 24 mL/min (4–68); 50.4% were diabetic, BMI was ≥ 30 kg/m2 in 40.4%. Normalization was the first step in 75 patients (57%, age 78 (24–101), CCI 8 (2–12), eGFR 24 mL/min (8–68)); moderately protein-restricted traditional diets were chosen by 24 (18%, age 74 (44–91), CCI 8 (4–14), eGFR 22 mL/min (5–40)), plant-based diets by 22 (17%, age 70 (34–89), CCI 6.5 (2–12), eGFR 15 mL/min (5–46)) (p < 0.001). Protein restriction was not undertaken in 10 patients with short life expectancy. In patients with ≥ 3 months of follow-up, median reduction of protein intake was from 1.2 to 0.8 g/kg/day (p < 0.001); nutritional parameters remained stable; albumin increased from 3.5 to 3.6 g/dL (p = 0.037); good compliance was found in 74%, regardless of diets. Over 1067 patient-months of follow-up, 9 patients died (CCI 10 (6–12)), 7 started dialysis (5 incremental). Conclusion: Protein restriction is feasible by an individualized, stepwise approach in an overall elderly, high-comorbidity population with a baseline high-protein diet and is compatible with stable nutritional status.
Mapping the Literature on Nutritional Interventions in Cognitive Health: A Data-Driven Approach
Authors: Walsh Erin I. , Cherbuin Nicolas
Published: December 2018

Manual review of the extensive literature covering nutrition-based lifestyle interventions to promote healthy cognitive ageing has proved educational, however, data-driven techniques can better account for the large size of the literature (tens of thousands of potentially relevant publications to date) and interdisciplinary nature, where relevant publications may be found. In this study, we present a new way to map the literature landscape, focusing on nutrition-based lifestyle interventions to promote healthy cognitive ageing. We applied a combination of citation network analysis and text mining to map out the existing literature on nutritional interventions and cognitive health. Results indicated five overarching clusters of publications, which could be further deconstructed into a total of 35 clusters. These could be broadly distinguished by the focus on lifespan stages (e.g., infancy versus older age), and specificity regarding nutrition (e.g., a narrow focus on iodine deficiency versus a broad focus on weight gain). Rather than concentrating into a single cluster, interventions were present throughout the majority of the research. We conclude that a data-driven map of the nutritional intervention literature can benefit the design of future interventions, by highlighting topics and themes that could be synthesized across currently disconnected clusters of publications.
Decrease of Antimicrobial Resistance through Polyelectrolyte-Coated Nanoliposomes Loaded with β-Lactam Drug
Authors: Arévalo Lina M. , Yarce Cristhian J. , Oñate-Garzón José , Salamanca Constain H.
Published: December 2018

Currently, one of the greatest health challenges worldwide is the resistance to antibiotic drugs, which has led to the pursuit of new alternatives for the recovery of biological activity, where the use of different types of nano-systems has shown an interesting potential. In this study, we evaluated the antibiotic activity of a model drug (ampicillin) encapsulated within coated-nanoliposomes on strains of Staphylococcus aureus with different antibiotic-resistance degrees. Hence, liposomes were elaborated by the ethanol injection method and were coated with a cationic polymer (Eudragit E-100) through the layer-by-layer process. Liposome characterization, such as size, polydispersity, zeta potential, and encapsulation efficiency were determined using dynamic light scattering and ultrafiltration/centrifugation techniques. Although biological activity was evaluated using three ATCC strains of S. aureus corresponding to ATCC 25923 (sensitive), ATCC 29213 (resistant) and ATCC 43300 (very resistant). The results showed changes in size (from ~150 to 220 nm), polydispersity (from 0.20 to 0.45) and zeta potential (from −37 to +45 mV) for the coating process. In contrast, encapsulation efficiency of approximately 70% and an increase in antibiotic activity of 4 and 18 times more on those S. aureus-resistant strains have been observed.
Effect of Shape on Mesoporous Silica Nanoparticles for Oral Delivery of Indomethacin
Authors: Zhang Wei , Zheng Nan , Chen Lu , Xie Luyao , Cui Mingshu , Li Sanming , Xu Lu
Published: December 2018

The use of mesoporous silica nanoparticles (MSNs) in the field of oral drug delivery has recently attracted greater attention. However, there is still limited knowledge about how the shape of MSNs affects drug delivery capacity. In our study, we fabricated mesoporous silica nanorods (MSNRs) to study the shape effects of MSNs on oral delivery. MSNRs were characterized by transmission electron microscopy (TEM), nitrogen adsorption/desorption, Fourier transform infrared spectroscopy (FTIR), and small-angle X-ray diffraction (small-angle XRD). Indomethacin (IMC), a non-steroidal anti-inflammatory agent, was loaded into MSNRs as model drug, and the drug-loaded MSNRs resulted in an excellent dissolution-enhancing effect. The cytotoxicity and in vivo pharmacokinetic studies indicated that MSNRs can be applied as a safe and efficient candidate for the delivery of insoluble drugs. The use of MSNs with a rod-like shape, as a drug delivery carrier, will extend the pharmaceutical applications of silica materials.
Biomedical Applications of Electrospun Nanofibers: Drug and Nanoparticle Delivery
Authors: Bhattarai Rajan Sharma , Bachu Rinda Devi , Boddu Sai H. S. , Bhaduri Sarit
Published: December 2018

The electrospinning process has gained popularity due to its ease of use, simplicity and diverse applications. The properties of electrospun fibers can be controlled by modifying either process variables (e.g., applied voltage, solution flow rate, and distance between charged capillary and collector) or polymeric solution properties (e.g., concentration, molecular weight, viscosity, surface tension, solvent volatility, conductivity, and surface charge density). However, many variables affecting electrospinning are interdependent. An optimized electrospinning process is one in which these parameters remain constant and continuously produce nanofibers consistent in physicochemical properties. In addition, nozzle configurations, such as single nozzle, coaxial, multi-jet electrospinning, have an impact on the fiber characteristics. The polymeric solution could be aqueous, a polymeric melt or an emulsion, which in turn leads to different types of nanofiber formation. Nanofiber properties can also be modified by polarity inversion and by varying the collector design. The active moiety is incorporated into polymeric fibers by blending, surface modification or emulsion formation. The nanofibers can be further modified to deliver multiple drugs, and multilayer polymer coating allows sustained release of the incorporated active moiety. Electrospun nanofibers prepared from polymers are used to deliver antibiotic and anticancer agents, DNA, RNA, proteins and growth factors. This review provides a compilation of studies involving the use of electrospun fibers in biomedical applications with emphasis on nanoparticle-impregnated nanofibers.
Electrospinning of Cyclodextrin Functional Nanofibers for Drug Delivery Applications
Authors: Topuz Fuat , Uyar Tamer
Published: December 2018

Electrospun nanofibers have sparked tremendous attention in drug delivery since they can offer high specific surface area, tailored release of drugs, controlled surface chemistry for preferred protein adsorption, and tunable porosity. Several functional motifs were incorporated into electrospun nanofibers to greatly expand their drug loading capacity or to provide the sustained release of the embedded drug molecules. In this regard, cyclodextrins (CyD) are considered as ideal drug carrier molecules as they are natural, edible, and biocompatible compounds with a truncated cone-shape with a relatively hydrophobic cavity interior for complexation with hydrophobic drugs and a hydrophilic exterior to increase the water-solubility of drugs. Further, the formation of CyD-drug inclusion complexes can protect drug molecules from physiological degradation, or elimination and thus increases the stability and bioavailability of drugs, of which the release takes place with time, accompanied by fiber degradation. In this review, we summarize studies related to CyD-functional electrospun nanofibers for drug delivery applications. The review begins with an introductory description of electrospinning; the structure, properties, and toxicology of CyD; and CyD-drug complexation. Thereafter, the release of various drug molecules from CyD-functional electrospun nanofibers is provided in subsequent sections. The review concludes with a summary and outlook on material strategies.
Engineering of Nanofibrous Amorphous and Crystalline Solid Dispersions for Oral Drug Delivery
Authors: Modica de Mohac Laura , Keating Alison Veronica , De Fátima Pina Maria , Raimi-Abraham Bahijja Tolulope
Published: December 2018

Poor aqueous solubility (<0.1 mg/mL) affects a significant number of drugs currently on the market or under development. Several formulation strategies including salt formation, particle size reduction, and solid dispersion approaches have been employed with varied success. In this review, we focus primarily on the emerging trends in the generation of amorphous and micro/nano-crystalline solid dispersions using electrospinning to improve the dissolution rate and in turn the bioavailability of poorly water-soluble drugs. Electrospinning is a simple but versatile process that utilizes electrostatic forces to generate polymeric fibers and has been used for over 100 years to generate synthetic fibers. We discuss the various electrospinning studies and spinneret types that have been used to generate amorphous and crystalline solid dispersions.
Evaluating the Effectiveness of Clinical Pharmacy Consultations on Nutrition, Physical Activity, and Sleep in Improving Patient-Reported Psychiatric Outcomes for Individuals with Mental Illnesses
Authors: Bingham Jennifer , Axon David R. , Scovis Nicole , Taylor Ann M.
Published: December 2018

One fifth of U.S. adults have a current mental illness. Nutrition, physical activity, and sleep are critical to physical health; any related deficiencies may worsen existing mental health conditions. Little is known about the impact of clinical pharmacist assessment and consultation in improving physical and mental health outcomes. The study objective was to determine whether patients’ mental health status improved following clinical pharmacist consultation. This pilot study involved clinical pharmacist-delivered services at an integrated medical behavioral health clinic in June 2018. Inclusion criteria required adults aged 18 years older, an established mental health diagnosis, and taking ≥2 prescribed psychotropic medications. One pharmacist conducted telephonic, medical, and psychiatric health risk assessment and counseling to improve nutrition, physical activity, and sleep status, both initially and at two-week follow-up. The Duke Health Profile (Duke) physical, anxiety, depression, and anxiety-depression scores measured patients’ pre/post changes. Participants (n = 20) experienced higher Duke physical scores (p = 0.007) and significantly lower anxiety (p = 0.025), depression (p = 0.001) and anxiety-depression scores (p = 0.005) at follow-up. This pilot study provides preliminary evidence for pharmacist-led, targeted, telephonic counseling in improving short-term physical and mental Duke health scores. Further research evaluating the impact of clinical pharmacists’ role in improving physical and behavioral health outcomes is warranted.
Effects of Growth Regulators and Gelling Agents on Ex Vitro Rooting of Raspberry
Authors: Lebedev Vadim , Arkaev Mikhail , Dremova Mariya , Pozdniakov Ivan , Shestibratov Konstantin
Published: December 2018

Successful acclimatization and ex vitro rooting are among the key factors reducing the cost of micropropagated plants. We compared the survival of seven Russian cultivars of raspberry (Rubus idaeus) after rooting in vitro and ex vitro. Rooted shoots adapted to nonsterile conditions much better than nonrooted ones, with survival rates of 81%–98% versus 43%–76%, respectively. We studied the effects of different combinations of plant-growth regulators and gelling agents added to a proliferation medium on ex vitro rooting of primocane-fruiting raspberry cultivar “Atlant”. Reducing the agar concentration from 8 to 6.5 g/L increased the multiplication rate, but caused shoot hyperhydricity. The highest survival rate (97.2%) was observed for shoots grown in a medium containing 0.2 and 0.1 mg/L IBA, and gelled with 5 g/L agar and 0.2 g/L Phytagel. The microshoot height at the multiplication stage did not correlate with the plant growth during acclimatization. The obtained results can be used in the commercial micropropagation of the raspberry.