bluuebunny/crossref_metadata_2025 huggingface dataset:
DeepAR: a novel deep learning-based hybrid framework for the interpretable prediction of androgen receptor antagonists
Authors: Schaduangrat Nalini , Anuwongcharoen Nuttapat , Charoenkwan Phasit , Shoombuatong Watshara
Published: May 2023

Drug resistance represents a major obstacle to therapeutic innovations and is a prevalent feature in prostate cancer (PCa). Androgen receptors (ARs) are the hallmark therapeutic target for prostate cancer modulation and AR antagonists have achieved great success. However, rapid emergence of resistance contributing to PCa progression is the ultimate burden of their long-term usage. Hence, the discovery and development of AR antagonists with capability to combat the resistance, remains an avenue for further exploration. Therefore, this study proposes a novel deep learning (DL)-based hybrid framework, named DeepAR, to accurately and rapidly identify AR antagonists by using only the SMILES notation. Specifically, DeepAR is capable of extracting and learning the key information embedded in AR antagonists. Firstly, we established a benchmark dataset by collecting active and inactive compounds against AR from the ChEMBL database. Based on this dataset, we developed and optimized a collection of baseline models by using a comprehensive set of well-known molecular descriptors and machine learning algorithms. Then, these baseline models were utilized for creating probabilistic features. Finally, these probabilistic features were combined and used for the construction of a meta-model based on a one-dimensional convolutional neural network. Experimental results indicated that DeepAR is a more accurate and stable approach for identifying AR antagonists in terms of the independent test dataset, by achieving an accuracy of 0.911 and MCC of 0.823. In addition, our proposed framework is able to provide feature importance information by leveraging a popular computational approach, named SHapley Additive exPlanations (SHAP). In the meanwhile, the characterization and analysis of potential AR antagonist candidates were achieved through the SHAP waterfall plot and molecular docking. The analysis inferred that N-heterocyclic moieties, halogenated substituents, and a cyano functional group were significant determinants of potential AR antagonists. Lastly, we implemented an online web server by using DeepAR (at http://pmlabstack.pythonanywhere.com/DeepAR). We anticipate that DeepAR could be a useful computational tool for community-wide facilitation of AR candidates from a large number of uncharacterized compounds.
Antibiotic stewardship in the ICU: time to shift into overdrive
Authors: Mokrani David , Chommeloux Juliette , Pineton de Chambrun Marc , Hékimian Guillaume , Luyt Charles-Edouard
Published: May 2023

Antibiotic resistance is a major health problem and will be probably one of the leading causes of deaths in the coming years. One of the most effective ways to fight against resistance is to decrease antibiotic consumption. Intensive care units (ICUs) are places where antibiotics are widely prescribed, and where multidrug-resistant pathogens are frequently encountered. However, ICU physicians may have opportunities to decrease antibiotics consumption and to apply antimicrobial stewardship programs. The main measures that may be implemented include refraining from immediate prescription of antibiotics when infection is suspected (except in patients with shock, where immediate administration of antibiotics is essential); limiting empiric broad-spectrum antibiotics (including anti-MRSA antibiotics) in patients without risk factors for multidrug-resistant pathogens; switching to monotherapy instead of combination therapy and narrowing spectrum when culture and susceptibility tests results are available; limiting the use of carbapenems to extended-spectrum beta-lactamase-producing Enterobacteriaceae, and new beta-lactams to difficult-to-treat pathogen (when these news beta-lactams are the only available option); and shortening the duration of antimicrobial treatment, the use of procalcitonin being one tool to attain this goal. Antimicrobial stewardship programs should combine these measures rather than applying a single one. ICUs and ICU physicians should be at the frontline for developing antimicrobial stewardship programs.
Investigating the facilitating conditions, perceived ease of use and usefulness of mobile-assisted language learning
Authors: Ebadi Saman , Raygan Ali
Published: May 2023

Mobile technologies and factors influencing English as a foreign language (EFL) learners’ willingness to integrate them into their learning processes are significant. This study aims at investigating the role of facilitating conditions, perceived ease of use, and perceived usefulness as factors in predicting Iranian EFL learners’ perceptions toward mobile-assisted language learning (MALL). Accordingly, data were collected from 223 Iranian EFL learners who had their English language courses in the two major educational contexts (i.e., public schools and private institutes). Considering the first phase of the study, a statistically significant relationship was found between the three hypothesized factors (i.e., facilitating conditions, perceived ease of use, and perceived usefulness) and learners’ perceptions toward MALL. Furthermore, the facilitating conditions were associated with learners’ perceived ease of use. Regarding the second phase of the study, the analysis of the path coefficients indicated a significant predictive power of perceived usefulness on perceptions toward MALL. Also indicated in this study is the significant effect of facilitating conditions on learners’ perceived ease of use. The results are discussed in the light of the literature, and suggestions for further research are provided.
Regional terrain-based VS30 prediction models for China
Authors: Zhang Yuting , Ren Yefei , Wen Ruizhi , Wang Hongwei , Ji Kun
Published: May 2023

Time-averaged shear-wave velocity to 30 m (VS30) is commonly used in ground motion models as a parameter for evaluating site effects. This study used a collection of boreholes in Beijing, Tianjin, Guangxi, Guangdong, and three other municipalities and provinces, which were divided into three regions with reference to the seismic ground motion parameter zonation map of China, to establish VS30 prediction models based on terrain categories. Regional effects were verified by comparing morphometric parameter (topographic slope, surface texture, and local convexity) thresholds and terrain classification maps obtained from global digital elevation model (DEM) data and regional DEM data of the three regions. Additionally, VS30 prediction models for the three regions using both types of terrain classification maps were established and analyzed comparatively to provide credible regional VS30 models for China. Through analysis of the correlations between the measured VS30 values and the predicted VS30 values, calculation of the mean squared error and mean absolute percentage error in each region, and with consideration of the geological characteristics of the boreholes, the VS30 prediction models based on terrain classification maps from regional data were finally applied in developing regional VS30 models for China. Intercomparison of the VS30 prediction models for the three regions indicated that subregional consideration is necessary in terrain classification. Finally, a spatial analysis method adopting inverse distance weighting of the residuals was used to update the initial VS30 models. The developed VS30 models could be used both in developing regional ground motion models and in the construction of earthquake disaster scenarios.

Graphical Abstract
Genomics in animal breeding from the perspectives of matrices and molecules
Authors: Johnsson Martin
Published: May 2023

Background

This paper describes genomics from two perspectives that are in use in animal breeding and genetics: a statistical perspective concentrating on models for estimating breeding values, and a sequence perspective concentrating on the function of DNA molecules.

Main body

This paper reviews the development of genomics in animal breeding and speculates on its future from these two perspectives. From the statistical perspective, genomic data are large sets of markers of ancestry; animal breeding makes use of them while remaining agnostic about their function. From the sequence perspective, genomic data are a source of causative variants; what animal breeding needs is to identify and make use of them.

Conclusion

The statistical perspective, in the form of genomic selection, is the more applicable in contemporary breeding. Animal genomics researchers using from the sequence perspective are still working towards this the isolation of causative variants, equipped with new technologies but continuing a decades-long line of research.
Online Contingent Attention Training (OCAT): transfer effects to cognitive biases, rumination, and anxiety symptoms from two proof-of-principle studies
Authors: Blanco Ivan , Boemo Teresa , Martin-Garcia Oscar , Koster Ernst H. W. , De Raedt Rudi , Sanchez-Lopez Alvaro
Published: May 2023

The aim of the present research was to develop and test the efficacy of a novel online contingent attention training (i.e., OCAT) to modify attention and interpretation biases, improve emotion regulation, and reduce emotional symptom levels in the face of major stressors. Two proof-of-principle studies were carried out. In study 1, 64 undergraduates who were about to start a major stressful period (i.e., final exams) were randomized to undergo 10 days of active OCAT or a sham-control training. Emotion regulation (habitual use of rumination and reappraisal) and symptom levels (depression and anxiety) were assessed before and after the intervention. In study 2, the same 2 × 2 mixed design was used with 58 individuals from the general population undergoing a major stressful situation (the lockdown period at the beginning of the COVID-19 pandemic in 2020). In both studies, the OCAT group showed significant improvements on attention towards negative information and interpretation biases in comparison to the sham-control group. Additionally, changes in cognitive biases transferred to reductions of participants’ use of rumination and anxiety symptom levels. These results show preliminary evidence regarding the efficacy of the OCAT to target attention and interpretation biases as well as to improve emotion regulation processes and to buffer against the effects of major stressors.
Radiographic assessment of third molar development and its relation to dental and chronological age in the Saudi Arabian population
Authors: Sindi Mohammed A , Al-Sebaei Maisa O , Bamashmous Mohamed S
Published: May 2023

Background

Radiology plays a vital role in determining human age. Age estimation based on radiographic evaluation of human third molars can prove useful and accurate. The present study aimed to evaluate the reliability of age estimation of the third molar and to study the effects of gender, arch, and side of third molars using the modified Demirjian and Moorrees classifications.

Methods

Orthopantomograms (OPG) of 6–24-year-old patients who attended our dental hospital were evaluated, and all eligible OPGs were analyzed for the test reliability based on the third molar modified Demirjian and Moorrees classifications. Statistical tests were performed to investigate the effect of gender, arch, and side.

Results

A total of 508 eligible OPGs were included in the study. Female subjects were 54.9%. The mean age was 14.69 ± 4.5 years. Based on each classification, each of the 3rd molars was significantly correlated with age (p < 0.001) with positive Pearson correlation values (r > 0.851).

Conclusions

The third molar modified Demirjian and Moorrees classifications were found to be highly accurate when used with our population. In addition, gender, arch, and side of third molars did not affect the estimated age.
Migraine among Egyptian medical students: prevalence, disability and psychological distress-cross sectional study
Authors: Ragab Salma , Zaitoun Nahla , Elrafie Ahmed , el-Ansarey Hussien , Srour Azza , Nabil Nada , Elshoura Yasmin , Elshafei Mohamed , Elgamal Shimaa
Published: May 2023

Background

Migraine is one of the most prevalent and disabling primary headache disorders. Migraine has many triggers factors as stress and irregular sleep pattern. Medical study in Egypt is so stressful with great psychological and physical burden; hence medical students are vulnerable to migraine. This study aims to determine the prevalence, characteristics, degree of disability, and psychological stress associated with migraine among medical students at different Egyptian universities.

Results

The overall prevalence of migraine was 17.27%, more in female (76.86%) than male. Sleeping disturbance and stress were the most common triggering factors associated with migraine (94.4%, 81.4% respectively). The majority of students with migraine (89.65%) had high psychological distress as measured by Kessler Psychological Distress Scale (K10) with moderate to severe disorder, while 76.8% had moderate to severe disability as assessed by Migraine Disability Assessment Score (MIDAS). Female gender was a potential predictor associated with higher psychological distress. There is negative correlation between degree of disability and academic performance.

Conclusion

Migraine is prevalent among medical students, with female predominance. It is associated with high level of psychological stress, moderate to severe disability, and negative impact on lifestyle and academic performance of the students.
Advancing collagen-based biomaterials for oral and craniofacial tissue regeneration
Authors: Zhang Bo , He Yunxiang , Liu Jialing , Shang Jiaojiao , Chen Chider , Wang Tianyi , Chen Mei , Li Yifei , Gong Guidong , Fang Jie , Zhao Zhihe , Guo Junling
Published: May 2023

The oral and craniofacial region consists of various types of hard and soft tissues with the intricate organization. With the high prevalence of tissue defects in this specific region, it is highly desirable to enhance tissue regeneration through the development and use of engineered biomaterials. Collagen, the major component of tissue extracellular matrix, has come into the limelight in regenerative medicine. Although collagen has been widely used as an essential component in biomaterial engineering owing to its low immunogenicity, high biocompatibility, and convenient extraction procedures, there is a limited number of reviews on this specific clinic sector. The need for mechanical enhancement and functional engineering drives intensive efforts in collagen-based biomaterials concentrating on therapeutical outcomes and clinical translation in oral and craniofacial tissue regeneration. Herein, we highlighted the status quo of the design and applications of collagen-based biomaterials in oral and craniofacial tissue reconstruction. The discussion expanded on the inspiration from the leather tanning process on modifications of collagen-based biomaterials and the prospects of multi-tissue reconstruction in this particular dynamic microenvironment. The existing findings will lay a new foundation for the optimization of current collagen-based biomaterials for rebuilding oral and craniofacial tissues in the future.

Graphical Abstract
Isolated variant of IgG4-sclerosing cholangitis masquerading as hilar cholangiocarcinoma — an enigmatic entity
Authors: Ravi Soundarya , Hanuman Srinivas Bheemanathi , Gnanasekhran Senthil , Pottakkat Biju
Published: May 2023

Background

IgG4-mediated sclerosing cholangitis (IgG4-SC) is an autoimmune disease that generally occurs in association with type 1 autoimmune pancreatitis (AIP). However, an isolated variant of IgG4-SC is a rare disease that can occur without concurrent AIP and closely mimics extrahepatic cholangiocarcinoma both clinically and radiologically.

Case presentation

Here, we report a case of an isolated variant of IgG4-SC, which was pre-operatively diagnosed as hilar cholangiocarcinoma. Pathological and immunohistochemical examination revealed features suggestive of IgG4-SC, which was confirmed by elevated serum IgG4 levels measured postoperatively.

Conclusion

Therefore, IgG4-SC should be carefully ruled out in patients presenting with isolated bile duct obstruction, before performing morbid surgical procedures.
Clinical value of acoustic radiation force impulse elastography in the prediction of hepatocellular carcinoma in chronic hepatitis C patients
Authors: Alem Shereen Abdel , omar Heba , Zayed Naglaa , Mabrouk Mahasen , Yosry Ayman
Published: May 2023

Background and purpose of the study

Acoustic radiation force impulse elastography (ARFI) represents an innovative non-invasive tool for the evaluation of liver fibrosis, cirrhosis, and early identification of neoplastic nodules during the follow-up of cirrhotic patients; however, its diagnostic accuracy in the prediction of hepatocellular carcinoma (HCC) is still controversial.

Purpose of the study

To assess the potential role of ARFI elastography as a non-invasive tool for the prediction of HCC development among chronic hepatitis C (CHC) patients with advanced hepatic fibrosis and liver cirrhosis.

Methods

The present study recruited 440 patients: 349 CHC patients with advanced hepatic fibrosis and cirrhosis and 91 patients with HCC-related hepatitis C virus (HCV). ARFI-imaging of the liver and transient elastography (TE) was carried out in all patients. ARFI imaging indices include the mean shear wave velocity of HCC, peritumoral parenchyma, and hepatic parenchyma in non-HCC patients. The area under the receiver operating characteristic curve (AUROC) and optimal cutoff values were obtained using a receiver operating characteristic curve analysis to assess the diagnostic performance of ARFI elastography in the predication of HCC.

Results

The mean hepatic shear wave velocities by ARFI elastography of peri-tumoral cirrhotic hepatic parenchyma were significantly higher than in hepatic parenchyma in non-HCC patients (3.09 vs. 2.26 m/s, p <0.001). The AUROC for the identification of HCC was 0.8, 0.76, 0.76, 0.66, 0.72, and 0.7 for hepatic ARFI elastography, TE, fibrosis-4 score (FIB-4), AST to Platelet Ratio Index (APRI), AST/ALT ratio (AAR), and Age platelets index (API), respectively. Moreover, univariate regression analysis revealed that hepatic ARFI has the highest odd ratio in the prediction of HCC.

Conclusion

ARFI elastography had a superior diagnostic performance in the prediction of HCC compared to TE and non-invasive markers in CHC patients with advanced fibrosis and cirrhosis, thus putting such patients on the top of the HCC screening list.
PARA A CRIAÇÃO DA ORGANIZAÇÃO INTERNACIONAL PARA PREVENÇÃO E REDUÇÃO DE CATÁSTROFES
Authors: Guerra Sidney , Araújo Brenda Maria Ramos , Santos Celso De Oliveira
Published: May 2023

Objetivo: Perante os problemas de cooperação enfrentados pelos Estados no combate a recentes cenários de catástrofes, o presente trabalho apresenta como tese a proposta de criação da Organização Internacional para Prevenção e Redução de Catástrofes (OIPRC). Como objetivos específicos, o trabalho pretende demonstrar como as organizações internacionais ajudam a solucionar problemas de cooperação em áreas específicas; propor órgãos executivos para estimular a cooperação dos Estados em cenários de catástrofes; propor órgãos administrativos e legislativos para solucionar a falta de regulamentação e criar suporte administrativo; propor mecanismo para solucionar eventuais conflitos entre Estados e garantir eficácia à regulamentação do Direito Internacional das Catástrofes.Metodologia: O método de abordagem será o dedutivo, sendo descritos os problemas de cooperação para sugerir possíveis órgãos competentes para solucioná-los. A técnica de pesquisa utilizada será a bibliográfica.Resultados: O trabalho conclui que a Organização Internacional para Prevenção e Redução de Catástrofes poderá solucionar os problemas de governança na área, mas deverá superar os desafios de sua criação.Contribuições: O artigo contribui para o aprimoramento da regulamentação do direito internacional para que ele consiga responder de forma eficaz às catástrofes. Na atual sociedade internacional, a potencialidade de ocorrerem catástrofes globais é maior. A Organização Internacional para Catástrofes objetiva criar uma regulamentação suficiente para prevenir, minimizar e superar a ocorrência dessas situações.
Porphyrins for medical and photocatalytic applications
Authors: Λάνδρου Γεώργιος
Published: May 2023

Η παρούσα διδακτορική διατριβή περιγράφει τη σύνθεση νέων χρωμοφόρων και την αξιοποίηση τους σε φωτοκαταλυτικές και ιατρικές εφαρμογές. Τα χρωμοφόρα που συντέθηκαν είναι υδατοδιαλυτές πορφυρίνες και νανοτελείες άνθρακα, τα οποία συνδυάστηκαν με καταλύτες για φωτοκαταλυτική παραγωγή υδρογόνου (H2) αλλά και με διπεπτίδια τόσο για αντιμικροβιακές όσο και εφαρμογές επούλωσης τραυμάτων.Οι απλές συνθετικές προσεγγίσεις, οι ελκυστικές φωτοφυσικές ιδιότητες και η ικανότητα διάλυσης στο νερό των χρωμοφόρων που συντέθηκαν αποτέλεσαν τις βασικές παραμέτρους για τις εφαρμογές που παρουσιάζονται. Πιο συγκεκριμένα, οι χαρακτηριστικές πυρίδιλο ομάδες στη μέσο-θέση των συντιθέμενων πορφυρινικών παραγώγων κατά τη μεθυλίωση τους εξασφαλίζουν διαλυτότητα στο νερό. Επίσης, διαφορετικά κεντρικά μεταλλικά ιόντα, όπως ο ψευδάργυρος, ο κασσίτερος, το κοβάλτιο και το νικέλιο μετασχηματίζουν τις ιδιότητες των παραγώγων πορφυρίνης που προέκυψαν. Παράλληλα, οι νανοτελείες άνθρακα, ως υλικά με εξαιρετική ικανότητα απορρόφησης του φωτός εξασφαλίζουν μοναδικές ιδιότητες και χαμηλού κόστους σύνθεση. Επιπλέον, η δυνατότητα παραμετροποίησης της επιφάνειας αυτών των υλικών με πηγές αζώτου, τροποποιεί τις ιδιότητές τους δίνοντας νέα χαρακτηριστικά.Η παρούσα διατριβή χωρίζεται σε δύο κύριες ενότητες. Η πρώτη ενότητα είναι εμπνευσμένη από τη φυσική φωτοσύνθεση. Τα υδατοδιαλυτά χρωμοφόρα που συνθέσαμε τα συνδυάσαμε με μοριακούς καταλύτες κοβαλτίου και νικελίου για τη μετατροπή τα πρωτονίων του νερού σε Η2. Ταυτόχρονα αξιολογήσαμε διάφορους παράγοντες που καθορίζουν την απόδοση του φωτοκαταλυτικού συστήματος, προκειμένου να μεγιστοποιηθεί η παραγωγή Η2. Συγκεκριμένα, οι σημαντικότεροι παράγοντες που διερευνήθηκαν είναι: το φορτίο των πορφυρινών, το ρυθμιστικό διάλυμα, η πηγή φωτός και η αναλογία φωτοευαισθητοποιητή και καταλύτη. Επίσης πραγματοποιθήκε εκτενής φωτοφυσική και ηλεκτροχημική έρευνα προκειμένου να προσδιοριστεί ο μηχανισμός της φωτοκαταλυτικής παραγωγής Η2. Είναι αξιοσημείωτο ότι, εκτός από τη χρήση εμπορικών πηγών φωτός, δοκιμάσαμε τη φωτοκατάλυση και σε πραγματικές συνθήκες, κάτω από το φως του ήλιου. Με αυτό τον τρόπο λάβαμε σημαντικές παρατηρήσεις οι οποίες θα είναι χρήσιμες για μελλοντικές μελέτες.Η επόμενη ενότητα ασχολείται με την ενσωμάτωση των υδατοδιαλυτών χρωμοφόρων σε δίκτυα υδρογέλης, τα οποία σχηματίστηκαν από διπεπτίδια με την προστατευτική ομάδα –Fmoc, μέσω διαμοριακών αλληλεπιδράσεων. Οι υδρογέλες που σχηματίστηκαν μελετήθηκαν σε προηγμένες αντιμικροβιακές εφαρμογές σε βακτήρια και σκουλήκια όπως το C. elegance. Παράλληλα, πραγματοποιήθηκαν πολυάριθμες μελέτες, όπως η κυτταροτοξικότητα και η επίδραση του ορατού φωτός στις προκύπτουσες υδρογέλες.Τέλος, εξετάστηκε η επούλωση πληγών στο δέρμα του αρουραίου Wistar κατά την εφαρμογή των συντιθέμενων υδρογελών. Η διαδικασία επούλωσης των πληγών μελετήθηκε τόσο σε νεαρά όσο και σε ηλικιωμένα ζώα έτσι ώστε να προκύψει μία ολοκληρωμένη ανάλυση των αποτελεσμάτων. Ο έλεγχος της αποτελεσματικότητας των υδρογελών εξασφαλίζει πολύτιμα αποτελέσματα για μελλοντικές κλινικές μελέτες.
Χωροχρόνοι με ιδιομορφίες στη Γενική Σχετικότητα
Authors: Κοτοπούλης Δημήτριος
Published: May 2023

Η παρούσα διατριβή άπτεται δύο θεμελιωδών προβλημάτων της σύγχρονης Θεωρητικής Φυσικής καθώς αφορά αφ᾽ενός μεν στη γενίκευση της Θερμοδυναμικής στο επίπεδο της Γενικής Σχετικότητος, αφ᾽ετέρου δε στο ζήτημα των χωροχρονικών ιδιομορφιών (spacetime singularities). Επικεντρώνεται στην πρόταση των Χ. Αναστόπουλου και Ν. Σαββίδου για την Θερμοδυναμική των συστημάτων ιδιοβαρύτητας (self-gravitating systems) στα πλαίσια της οποίας οι χωροχρονικές ιδιομορφίες αντιμετωπίζονται όχι ως παθογένειες, αλλά ως θερμοδυναμικές οντότητες στις οποίες αποδίδεται εντροπία. Η συνεισφορά της διατριβής έγκειται στην διερεύνηση της εφαρμοσιμότητας της πρότασης αυτής για δύο περιπτώσεις σφαιρικά συμμετρικών συστημάτων ιδιοβαρύτητας, ήτοι ενός τρισδιάστατου φλοιού θερμικής ακτινοβολίας και ενός λεπτού φλοιού απειροστού πάχους. Σε αμφότερες τις περιπτώσεις ο φλοιός και ο κενός χωροχρόνος που αυτός περικλείει αντιμετωπίζονται ως συνιστώσες ενός ενιαίου κλειστού θερμοδυναμικού συστήματος που μελετάται στη βάση της Αρχής Μεγίστης Εντροπίας. Ο χωροχρόνος στο εσωτερικό του φλοιού περιγράφεται από την γεωμετρία Σβάρτσιλντ (K.Schwarzschild) η οποία ανάλογα με το πρόσημο της μάζας αντιστοιχεί σε μελανή οπή ή σε παρατηρήσιμη χωροχρονική ιδιομορφία ή στον επίπεδο χωροχρόνο της Ειδικής Σχετικότητος. Οι διαφορετικές γεωμετρίες ερμηνεύονται ως διαφορετικές θερμοδυναμικές φάσεις και διερευνώνται οι μεταξύ τους μεταβάσεις. Αποδεικνύεται ότι η απόδοση εντροπίας στις χωροχρονικές ιδιομορφίες στη βάση της ως άνω πρότασης επιτρέπει την επίτευξη μιας συνεπούς θερμοδυναμικής περιγραφής, κάτι που συνηγορεί υπέρ της εγκυρότητάς της για τους σφαιρικά συμμετρικούς χωροχρόνους εν γένει.
Ο Αριστοφάνης σε σκηνική παρουσίαση
Authors: Ευστρατίου Χαρίσιος
Published: May 2023

Η παρούσα μελέτη έχει ως στόχο να αναδείξει σκηνικά ζητήματα το οποία παράγονται από το κείμενο, καθώς επίσης και από το περιβάλλον του θεάτρου, το διαγωνιστικό του πλαίσιο, το σκηνικό οικοδόμημα, τον κοινωνικό ιστό μέσα στον οποίο ο Αριστοφάνης δραστηριοποιείται, συνθέτει τα έργα του και του αποτείνεται. Εξετάζονται οι είσοδοι και οι έξοδοι, η διαχείριση του χώρου και του χρόνου, οι σιωπές στο ηχηρό κωμικό θέατρο, οι μονόλογοι, οι παράμεροι λόγοι, η ενδεχόμενη παρουσία γυμνών κοριτσιών επί σκηνής, η δραματική ψευδαίσθηση, το πορνικό και το κοπρολογικό λεξιλόγιο.
Elastic scattering measurements of 7Be+natZr at sub- and near – barrier energies
Authors: Pakou Athena
Published: May 2023

We will present a recent experiment for elastic scattering of 7Be+natZr at five sub – and near- barrier energies, namely at 21.5, 22.5, 24, 27 and 28 MeV, for determining the optical potential. The experiment was performed at the TriSol radioactive beam facility of Notre Dame University, simultaneously with elastic scattering and breakup measurements of 8B+90Zr , the last performed at 28MeV. This optical potential will be used as one of the coupling potentials in our CDCC calculations for 8B. Further more we will look for the energy dependence of the potential and its resemblance to either the one exhibited by 7Li or the one by 6Li, extracting useful conclusions about their structure. Preliminary data are presented and discussed.
A study of the reaction 55Mn(p,4n)52Fe: excitation function and medical applications
Authors: Nicolis Nikolaos George , Tsitsis George-Rafael
Published: May 2023

The present study concerns the medical applications and production of  52Fe via the reaction 55Mn(p,4n)52Fe together with the reference reaction 27Al(p,x)22Na employed in cross section measurements. Experimental excitation functions from threshold up to 200 MeV are compared with the predictions of the TALYS 1.95 code and the semi-empirical formulas SPACS and Silberberg & Tsao. We obtained two TALYS parameter sets for the 55Mn(p,4n)52Fe and 27Al(p,x)22Na reactions which give a good description of the excitation functions for energies up to 85 MeV. Discrepancies observed at higher energies require further investigation. The semi-empirical formulas provide a good description of the excitation functions above 120 MeV.
Nuclear astrophysics at n_TOF: focus on neutron sources in stars
Authors: Massimi Cristian
Published: May 2023

Since 2001, the neutron time-of-flight facility n_TOF at CERN has carried out a large number of cross section measurements of interest for several research fields, including Nuclear Astrophysics. The results of these measurements have improved our knowledge on the nucleosynthesis of chemical elements. Particularly relevant for the s process, reported cross sections were used to constrain the Big Bang nucleosynthesis, to benchmark stellar models against nucleosynthesis in quiet and explosive scenarios, to interpret meteoritic abundances, as well as to study the neutron source reactions in Red Giant stars. After a brief description of the n_TOF facility and the related astrophysical program, the research activities about the 13C(a,n)16O and 22Ne(a,n)25Mg neutron source reactions are discussed.
Universal relations and finite temperature neutron stars
Authors: Laskos-Patkos Pavlos , Koliogiannis Polychronis , Kanakis-Pegios Alkiviadis , Moustakidis Charalampos
Published: May 2023

In the past few years, a lot of studies devoted to the discovery of universal relations (equation of state independent relations). The significance of such expressions can be understood if we consider that they offer the opportunity for testing general relativity in a way that is independent of the nuclear equation of state and they also allow us to impose constraints on the structure of neutron stars. The aim of this work is twofold. Firstly, we wish to clarify if hot equations of state are able to reproduce established universal relations. Secondly, we investigate a possible universal connection between the binding energy and the dimensionless tidal deformability of a neutron star. These two bulk properties are associated with two very important candidates for multimessenger signals, binary neutron star mergers and supernova explosions. We find that the predictions of hot equations of state do not agree with the predictions from accepted universal relations. Subsequently,  the use of universal relations, when thermal effects are present, may be erroneous. Additionally, we find that, for moderate neutron star masses, the binding energy and the dimensionless tidal deformability of a neutron star satisfy a universal relation. The latter allows us to impose constraints on the binding energy of 1.4 Msun neutron star, using information from the analysis of the GW170817 event. Finally, we are able to present a universal relation between the compactness, the binding energy and the dimensionless tidal deformability, which is independent of the employed equation of state for zero and finite temperature.
Baryons and antibaryons in compressed nuclear matter
Authors: Gaitanos Theodoros , Chorozidou Arsenia
Published: May 2023

In this work we discuss the in-medium properties of baryons and antibaryons in nuclear matter at densities beyond saturation. We focus the attention on the in-medium optical potentials of heavy baryons with strangeness content. That is, the hyperons Λ, Σ with strangeness S=-1 and the cascade particle Ξ with S=-2 . The particular treatment of the hyperons  inside compressed matter is crucial in order to understand the in-medium modifications of baryons in matter conditions that may occur in the interior of neutron stars. We dicsuss further the properties of their antiparticles, since there are experimental data for the nucleonic sector (S=0) while for the strangeness sector (S=-1,-2) experimental information will be available in the close future at the new facilities, for instance, at FAIR and J-PARC.
Heterogeneous Architecture for DSRC/LTE Vehicular Communication Networks Based on the ITS Reference Architecture with Fuzzy Logic for Decision-Making
Authors: Agyare Michael , John Kponyo Jerry , Adu-Boahen Opare Kwasi , Oteng Gyasi Kwame
Published: May 2023

Methods to integrate different access technologies such as heterogeneous communication architecture remains a challenge. Among a variety of V2X-supporting access technologies, Dedicated Short Range Communication (DSRC) and cellular communications, e.g., Long Term Evolution (LTE) is promising reliable and efficient vehicular communications. DSRC has been designed to allow for direct low-latency communications among different vehicles (i.e., V2V) and between vehicles and roadside units (RSU). On the other hand, DSRC suffers from link quality degradation with the presence of buildings and vehicles, especially in urban areas, where channel collisions become serious when vehicle density is high. LTE networks can provide wide area coverage and are favorable to bandwidth-greedy applications, which require high data rates and reliability. Considering the relatively high end-to-end delay for message transmission due to the long transmission time interval (TTI) current LTE networks have drawbacks regarding latency to support highfrequency safety-related information exchange among vehicles in local areas. Combining LTE and DSRC approaches as a heterogeneous solution is essential to fast introduce V2X services for future automated driving. By this intelligent Vertical Handover (VHO) algorithms are needed to ensure seamless connectivity of vehicles to the best network at a particular point in time. For this paper, we propose a 3- input fuzzy-logic-based VHO scheme for Heterogeneous DSRC/LTE Vehicular Communication Networks. The simulation results in this paper show that the proposed 3- input fuzzy-logic model can be able to make decisions and select the best network to connect to base on the network with the highest HF value. The 3-input fuzzy-logic model was also tested in a vehicular highway scenario simulation. The proposed model shows optimized communication results in terms of the mean end-to-end delay against that of the literature.
“ONE NIGHTMARE REPLACES ANOTHER”: TRAUMA AND MOURNING IN THE AGE OF TERROR THROUGH PAUL AUSTER’S TRAVELS IN THE SCRIPTORIUM AND MAN IN THE DARK.
Authors: Rodríguez Arnaiz Laura
Published: May 2023

Los ataques terroristas del 11 de septiembre de 2001 ocasionaron una espiral de miedo e ira en la sociedad americana que tuvo como respuesta alguna de las medidas legislativas más controvertidas de su historia. El sentimiento de invencibilidad que había dominado el imaginario americano se evaporó ante el caos y el miedo de aquel día que posteriormente dieron forma a textos escritos por algunos de los escritores norteamericanos de mayor renombre. Entre ellos, Paul Auster con sus novelas sobre el 11-S, Travels in the Scriptorium (2007) y Man in the Dark (2008) que intentan responder a la inconmensurabilidad del 11-S a través de la angustia producida por el trauma físico y psicológico de dos ancianos encerrados en una habitación, donde la ficción se postula como la única salida a su confinamiento y donde la memoria individual e histórica se entrelazan con la crítica de Auster a la ‘Guerra contra el terror’.
Remitting seronegative symmetrical synovitis with pitting oedema following administration of the ChAdOx1-S/nCoV-19 Coronavirus vaccine
Authors: Muhammad Syed Aun , Coath Fiona , Jegard James
Published: May 2023

Introduction: We describe a case of remitting seronegative symmetrical synovitis with pitting oedema (RS3PE) syndrome following administration of the ChAdOx1-S/nCoV-19 [recombinant] vaccine, suggesting a possible causal link. Case Description: A 72-year-old man presented to his general practitioner with swollen, oedematous hands and legs 2 weeks after receiving a coronavirus vaccine. He had raised inflammatory markers but remained systemically well. He was initially presumed to have cellulitis, but his symptoms persisted despite several courses of antibiotics. Deep vein thromboses, cardiac failure, renal failure and hypoalbuminaemia were ruled out. Upon Rheumatology review, he was diagnosed as having RS3PE syndrome with the Covid vaccine suspected of being an immunogenic trigger. Following initiation of steroid therapy, his symptoms improved dramatically, as is characteristic of RS3PE syndrome. Discussion: The pathophysiology of RS3PE is unclear. It is known to have various triggers and associations including infections, certain vaccines and malignancy. This case highlights that a coronavirus vaccine (ChAdOx1-S/nCoV-19 [recombinant] vaccine) is also a possible trigger. Factors that make the diagnosis likely include an acute onset of symptoms including pitting oedema in a typical distribution, age above 50, and unremarkable autoimmune serology. Other learning points from this case include the importance of antibiotic stewardship and the need to explore non-infectious causes of illness when antibiotics do not improve symptoms. Conclusion: The ChAdOx1-S/nCoV-19 [recombinant] vaccine is a possible trigger of RS3PE. However, the benefits of vaccines against coronavirus outweigh the risks in the majority of patients.
Analyzing Nike's Concept of Women's Empowerment through Instagram Captions: A Critical Discourse Analysis
Authors: Nursagi Anisa Rizky Nola , Budiwati Tri Rina , Saad Nor Azyyati Md
Published: May 2023

Nike, a well-known sports brand, actively uses social media platforms to promote its brand and advocate for social movements, such as women's empowerment. The study aims to use Critical Discourse Analysis (CDA) to analyze Nike's Instagram captions that were posted in 2019 as a way of revealing the essential concept through language and the social practice level. This study uses qualitative research design and critical discourse analysis to analyze Nike's concept towards women in their Instagram captions. The researchers collected data using non-participative observation and purposive sampling techniques and analyzed the data using the referential identity and competence-in-dividing techniques. This study found that it had standard features like vocabulary, grammatical structure, and various textual features. Nike also used discourse practice by employing female athlete representatives to construct the concept of women empowerment in the caption. Furthermore, the language in the caption implied feminist ideology that helped instill the concept of women's empowerment by showing progressivity in the sports industry. The study analyzed Nike's Instagram captions and concluded that the company uses various textual features, including quotations from female athletes, to construct the concept of women's empowerment. Nike's use of persuasive language and representation of feminism ideology supports this concept. This research can have implications for media studies and critical discourse analysis in helping students decode semantic and syntactic choices in media texts.
The Utilization of Technology in Corporate Social Responsibility Activities: A Case Study of Sido Muncul's Shared Value Program in Sambirata Village during the COVID-19 Pandemic
Authors: Ayu Kilau Riksaning , Fuaddah Ashlikhatul , Sutikna Nana
Published: May 2023

Sido Muncul Company produces modern herbal medicines and has adopted the concept of creating shared value (CSV) to synergize community empowerment with their core business. They implemented a CSV program called Desa Rempah, which focuses on the potential of Sambirata Village's cardamom commodity. This study examines the utilization of technology in their CSV activities during the COVID-19 pandemic. This research utilized qualitative case study methods to gather primary and secondary data from various stakeholders, including companies, public relations officers, community development teams, and local leaders, to gain insights into implementing Corporate Social Responsibility (CSR) activities by PT Sido Muncul in Sambirata Village. The case study approach allowed for a subjective perspective on social reality and used theoretical propositions to generalize findings. The CSV program, Desa Rempah, addresses the company's need for raw materials and the farmer group's issues in processing cardamom. The COVID-19 pandemic posed challenges to CSV implementation. Still, the company adapted through digital transformations and prioritized the local community's efficiency and effectiveness in developing CSV activities with BumDes (Village Owned Enterprises) Sambirata. Sido Muncul's strategy for CSV activities involves social mapping research and collaboration with stakeholders, including government and Bumdes Sambirata, to create shared value through innovations and efficiency, effectiveness, and responsiveness. During the COVID-19 pandemic, the company collaborated with millennial farmers to overcome obstacles and increase farmers' independence, leading to higher-value dried cardamom and increased income for the farmer group.
Nurses' perceptions of patient safety culture: a local phenomenon?
Authors: Reyes Ramos Maria José , Ferrer Tarrés Joan M , Costa Abós Silvia
Published: May 2023

Background/Aims

Patient safety culture is the product of values, beliefs, attitudes, perceptions, competencies and individual and collective behaviour patterns. Nurses often have the most contact with patients, so their perceptions of patient safety are crucial. This study aimed to assess perceptions of patient safety culture among nurses at a hospital in Spain.

Methods

A cross-sectional study was conducted using an adapted version of the Hospital Survey on Patient Safety Culture questionnaire. All 244 nurses working in a hospital in Spain took part. Respondents reported their perceptions of patient safety culture in their department in 12 domains using a 5-point Likert scale, with additional questions measuring overall perceptions of patient safety culture, personal and professional characteristics, and the proportion of respondents who had reported a patient safety incident in the previous year. Univariate and bivariate data analysis was performed using Jamovi software to identify relationships between variables.

Results

None of the 12 domains had a positive response rate (over 75%), indicating a generally weak patient safety culture. Perceptions of patient safety culture varied between departments, and were also affected by respondents' professional characteristics, such as their years of experience and whether they held a managerial role.

Conclusions

Further research and intervention is needed to improve patient safety cultures. It may be useful to assess patient safety culture and tailor strategies for improvement according to the specific needs of individual departments.
The impact of poorly applied human resources policies on individuals and organisations
Authors: Neal Adrian , Cooper Andrew , Waites Benna , Bell Nick , Race Adam , Collinson Martin
Published: May 2023

Background/Aims

Recent incidents have raised awareness about how corporate decisions and behaviour can negatively affect the health and wellbeing of healthcare professionals. This article uses a case study to explore the harm that failing to follow human resources procedures can cause to individuals, organisational culture and effectiveness, and make recommendations to improve practice.

Methods

Seven experts from a range of professional backgrounds offered opinions on an individual case study involving the misapplication of a human resources policy, considering how it may have deviated from lawful practice and the potential impact this had on both the individual and the organisation. Thematic analysis was carried out on this qualitative feedback to identify superordinate and subordinate themes.

Results

The thematic analysis identified four superordinate themes: failure to follow organisational policies; impact on the individual; impact on the organisation; and failure to learn.

Conclusions

Poor application of human resources procedures can cause harm to individuals and organisations in a number of different ways. Human resources departments need to actively protect the health and wellbeing of the individual/s involved in investigative procedures, rather than focusing solely on executing the process.
Does Orthodontic Treatment Provide Long-term Improvements in Patients' Self-esteem and Oral Health-related Quality of Life? A Literature Review
Authors: Coffey Deirdre , Doody Katie
Published: May 2023

Orthodontic treatment is often provided on the assumption that improvements of oral function and aesthetics will result in improved self-esteem (SE) and oral health-related quality of life (OHRQoL). This article reviews the current available literature pertaining to the effect of orthodontic treatment on SE and OHRQoL, with a special focus on the longevity of any influence observed. Currently, there is no strong evidence to support that orthodontic treatment causes significant increases in SE and OHRQoL. Reports of treatment benefit in this regard remain equivocal, and the longevity of any effects on SE or OHRQoL remains unknown. This provides an insight into evidence-based treatment benefits and aids informed decision-making.

CPD/Clinical Relevance: An awareness of the effect of orthodontic treatment on self-esteem and oral health-related quality of life is important to allow a greater understanding of treatment benefit and satisfaction
Promoting Outcomes-Based Instructional Materials: Testing the Effectiveness of Print Modules for Business Students
Authors: Inarda Analyn V.
Published: May 2023

Education delivers systematic instruction so effective learning acquisition may take place. It molds students into holistic well-being to contribute to various industries; hence, relevant competencies are developed. Strengthening education significantly encompasses the production of formfitting and distinct instructional materials to invite a sequential way of presenting quality instruction. This research is focused on knowing the effectiveness of the modules developed in Human Resource Management for Filipino business students. Specifically, it is developmental research and utilizes a pretest and post-test control group design. Numerical data were supported by phenomenological interviews, strengthening the study's results. It involved 80 college students classified as the experimental and control group. Moreover, the interview includes 10 participants. Findings reveal that utilizing the modules realized the increase in performance of the experimental group due to their exposure to the materials. However, one of the pitfalls has been revealed in utilizing self-directed learning material; thus, academic performance will only improve if students are organized to set their own goals and learning pace. Using outcomes-based instructional materials leads to substantiating learning, effectively enticing learners' interest. It maximizes students' motivation and participation since topics are well-planned and designed comprehensively. The materials are an essential tool in inviting the enthusiasm of business students to engage in learning. These are valuable means to encourage independent learning without sacrificing the competencies to be learned and applied by the learners.