bluuebunny/crossref_metadata_2025 huggingface dataset:
Rheumatic Myocarditis: A Poorly Recognized Etiology of Left Ventricular Dysfunction in Valvular Heart Disease Patients
Authors: Rosa Vitor Emer Egypto , Lopes Mariana Pezzute , Spina Guilherme Sobreira , Soares Junior Jose , Salazar David , Romero Cristhian Espinoza , Lottenberg Marcos Pita , de Santis Antonio , Pires Lucas José Neves Tachotti , Gonçalves Luis Fernando Tonello , Fernandes Joao Ricardo Cordeiro , Sampaio Roney Orismar , Tarasoutchi Flavio
Published: June 2021

Background: Heart failure occurs in ~10% of patients with acute rheumatic fever (RF), and several studies have shown that cardiac decompensation in RF results primarily from valvular disease and is not due to primary myocarditis. However, the literature on this topic is scarce, and a recent case series has shown that recurrent RF can cause ventricular dysfunction even in the absence of valvular heart disease.

Methods: The present study evaluated the clinical, laboratory and imaging characteristics of 25 consecutive patients with a clinical diagnosis of myocarditis confirmed by 18F-FDG PET/CT or gallium-67 cardiac scintigraphy and RF reactivation according to the revised Jones Criteria. Patients underwent three sequential echocardiograms at (1) baseline, (2) during myocarditis and (3) post corticosteroid treatment. Patients were divided according to the presence (Group 1) or absence (Group 2) of reduced left ventricular ejection fraction (LVEF) during myocarditis episodes.

Results: The median age was 42 (17–51) years, 64% of patients were older than 40 years, and 64% were women. Between Group 1 (n = 16) and in Group 2 (n = 9), there were no demographic, echocardiographic or laboratory differences except for NYHA III/IV heart failure (Group 1: 100.0% vs. Group 2: 50.0%; p = 0.012) and LVEF (30 [25–37] vs. 56 [49–62]%, respectively; p < 0.001), as expected. Group 1 patients showed a significant reduction in LVEF during carditis with further improvement after treatment. There was no correlation between LVEF and valvular dysfunction during myocarditis. Among all patients, 19 (76%) underwent 18F-FDG PET/CT, with a positive scan in 68.4%, and 21 (84%) underwent gallium-67 cardiac scintigraphy, with positive uptake in 95.2%, there was no difference between these groups.

Conclusion: Myocarditis due to rheumatic fever reactivation can cause left ventricular dysfunction despite valvular disease, and it is reversible after corticosteroid treatment.
Evaluation of Remote Mapping Techniques for Earthquake-Triggered Landslide Inventories in an Urban Subarctic Environment: A Case Study of the 2018 Anchorage, Alaska Earthquake
Authors: Martinez S. N. , Schaefer L. N. , Allstadt K. E. , Thompson E. M.
Published: June 2021

Earthquake-induced landslide inventories can be generated using field observations but doing so can be challenging if the affected landscape is large or inaccessible after an earthquake. Remote sensing data can be used to help overcome these limitations. The effectiveness of remotely sensed data to produce landslide inventories, however, is dependent on a variety of factors, such as the extent of coverage, timing, and data quality, as well as environmental factors such as atmospheric interference (e.g., clouds, water vapor) or snow and vegetation cover. With these challenges in mind, we use a combination of field observations and remote sensing data from multispectral, light detection and ranging (lidar), and synthetic aperture radar (SAR) sensors to produce a ground failure inventory for the urban areas affected by the 2018 magnitude (Mw) 7.1 Anchorage, Alaska earthquake. The earthquake occurred during late November at high latitude (∼61°N), and the lack of sunlight, persistent cloud cover, and snow cover that occurred after the earthquake made remote mapping challenging for this event. Despite these challenges, 43 landslides were manually mapped and classified using a combination of the datasets mentioned previously. Using this manually compiled inventory, we investigate the individual performance and reliability of three remote sensing techniques in this environment not typically hospitable to remotely sensed mapping. We found that differencing pre- and post-event normalized difference vegetation index maps and lidar worked best for identifying soil slumps and rapid soil flows, but not as well for small soil slides, soil block slides and rock falls. The SAR-based methods did not work well for identifying any landslide types because of high noise levels likely related to snow. Some landslides, especially those that resulted in minor surface displacement, were identifiable only from the field observations. This work highlights the importance of the rapid collection of field observations and provides guidance for future mappers on which techniques, or combination of techniques, will be most effective at remotely mapping landslides in a subarctic and urban environment.
A Preliminary Psychometric Investigation of a Chinese Version of the Engaged Teachers Scale (C-ETS)
Authors: Ho Sammy K. , Chan Hang , Chan Edmund Sze-Shing , Fung Kwok-Kin , Hung Shirley Suet-Lin
Published: June 2021

This study examines the psychometric properties of a Chinese version of the Engaged Teacher Scale (C-ETS). A translated questionnaire with 16 items was administered to a sample of 341 primary and secondary school teachers in Hong Kong. A series of confirmatory factor analyses were performed to assess the construct, convergent, and discriminant validity of the scale in alternative models. Results provide support for a second-order model with teacher engagement as an overarching construct with four hypothesized dimensions: emotional engagement, cognitive engagement, social engagement (students), and social engagement (colleagues). The C-ETS provides a useful measure for teacher engagement in Chinese societies. Contributions and limitations of the study are discussed.
SVD Entropy Reveals the High Complexity of Ecological Networks
Authors: Strydom Tanya , Dalla Riva Giulio V. , Poisot Timothée
Published: June 2021

Quantifying the complexity of ecological networks has remained elusive. Primarily, complexity has been defined on the basis of the structural (or behavioural) complexity of the system. These definitions ignore the notion of “physical complexity,” which can measure the amount of information contained in an ecological network, and how difficult it would be to compress. We present relative rank deficiency and SVD entropy as measures of “external” and “internal” complexity, respectively. Using bipartite ecological networks, we find that they all show a very high, almost maximal, physical complexity. Pollination networks, in particular, are more complex when compared to other types of interactions. In addition, we find that SVD entropy relates to other structural measures of complexity (nestedness, connectance, and spectral radius), but does not inform about the resilience of a network when using simulated extinction cascades, which has previously been reported for structural measures of complexity. We argue that SVD entropy provides a fundamentally more “correct” measure of network complexity and should be added to the toolkit of descriptors of ecological networks moving forward.
Review: Vaccine Myth-Buster – Cleaning Up With Prejudices and Dangerous Misinformation
Authors: Löffler Paul
Published: June 2021

Although vaccines have already saved and will continue to save millions of lives, they are under attack. Vaccine safety is the main target of criticism. The rapid distribution of false information, or even conspiracy theories on the internet has tremendously favored vaccine hesitancy. The World Health Organization (WHO) named vaccine hesitancy one of the top ten threats to global health in 2019. Parents and patients have several concerns about vaccine safety, of which the ubiquitous anxieties include inactivating agents, adjuvants, preservatives, or new technologies such as genetic vaccines. In general, increasing doubts concerning side effects have been observed, which may lead to an increasing mistrust of scientific results and thus, the scientific method. Hence, this review targets five topics concerning vaccines and reviews current scientific publications in order to summarize the available information refuting conspiracy theories and myths about vaccination. The topics have been selected based on the author’s personal perception of the most frequently occurring safety controversies: the inactivation agent formaldehyde, the adjuvant aluminum, the preservative mercury, the mistakenly-drawn correlation between vaccines and autism and genetic vaccines. The scientific literature shows that vaccine safety is constantly studied. Furthermore, the literature does not support the allegations that vaccines may cause a serious threat to general human life. The author suggests that more researchers explaining their research ideas, methods and results publicly could strengthen the general confidence in science. In general, vaccines present one of the safest and most cost-effective medications and none of the targeted topics raised serious health concerns.
Venom-Induced Blood Disturbances by Palearctic Viperid Snakes, and Their Relative Neutralization by Antivenoms and Enzyme-Inhibitors
Authors: Chowdhury Abhinandan , Zdenek Christina N. , Lewin Matthew R. , Carter Rebecca , Jagar Tomaž , Ostanek Erika , Harjen Hannah , Aldridge Matt , Soria Raul , Haw Grace , Fry Bryan G.
Published: June 2021

Palearctic vipers are medically significant snakes in the genera Daboia, Macrovipera, Montivipera, and Vipera which occur throughout Europe, Central Asia, Near and Middle East. While the ancestral condition is that of a small-bodied, lowland species, extensive diversification has occurred in body size, and niche specialization. Using 27 venom samples and a panel of in vitro coagulation assays, we evaluated the relative coagulotoxic potency of Palearctic viper venoms and compared their neutralization by three antivenoms (Insoserp Europe, VIPERFAV and ViperaTAb) and two metalloprotease inhibitors (prinomastat and DMPS). We show that variation in morphology parallels variation in the Factor X activating procoagulant toxicity, with the three convergent evolutions of larger body sizes (Daboia genus, Macrovipera genus, and Vipera ammodytes uniquely within the Vipera genus) were each accompanied by a significant increase in procoagulant potency. In contrast, the two convergent evolutions of high altitude specialization (the Montivipera genus and Vipera latastei uniquely within the Vipera genus) were each accompanied by a shift away from procoagulant action, with the Montivipera species being particularly potently anticoagulant. Inoserp Europe and VIPERFAV antivenoms were both effective against a broad range of Vipera species, with Inoserp able to neutralize additional species relative to VIPERFAV, reflective of its more complex antivenom immunization mixture. In contrast, ViperaTAb was extremely potent in neutralizing V. berus but, reflective of this being a monovalent antivenom, it was not effective against other Vipera species. The enzyme inhibitor prinomastat efficiently neutralized the metalloprotease-driven Factor X activation of the procoagulant venoms. In contrast, DMPS (2,3-dimercapto-1-propanesulfonic acid), which as been suggested as another potential treatment option in the absence of antivenom, DMPS failed against all venoms tested. Overall, our results highlight the evolutionary variations within Palearctic vipers and help to inform clinical management of viper envenomation.
Look Who’s Asking—Reflections on Participatory and Transdisciplinary Marine Research Approaches
Authors: Breckwoldt Annette , Lopes Priscila F. M. , Selim Samiya A.
Published: June 2021

Marine conservation transdisciplinary researchers often get to the field with a previously designed question, often formulated outside the actual geographical, social, cultural and ecological setting in which the research projects are supposed to be anchored. Involving people on the ground in the initial phase of formulating the questions and setting the research agenda is still uncommon. Once in the field, transdisciplinary researchers may or may not have the support of local communities to sample their data, although they will regularly need to count on these same communities if a collaborative regime is to be pursued and informed by the research outcome. This paper discusses measures that can be taken by marine fisheries and marine conservation researchers to improve participation in, and ownership of, the research by local counterparts, most importantly members of the communities where research is being conducted. The data was generated with a purposively sampled survey of 18 members of our research networks. Key proposed measures derived from this data include: (1) build rapport; (2) engage and exchange; (3) be accommodating and attentive; and (4) be respectful. Knowing who is asking the questions and assuring that all stakeholders have a voice in this process becomes especially relevant under extreme circumstances (e.g., disasters, pandemics), when problems are numerous but can only be accessed by those on the ground. We advise for faster progress in transforming academic and funding environments for true “level-playing-field” transdisciplinary and co-designed research projects that can help change top-down research tendencies.
Sustained Competitive Advantage Based on Industry-Specific Institutional Frameworks
Authors: Bertheussen Bernt Arne
Published: June 2021

This study investigates the relationships between industry-specific institutions, industry structure, and industry performance. The Norwegian Pelagic value chain’s harvesting industry and its processing industry comprised the empirical context. The study findings reveal that the harvesters (the fishers), on average, achieved nearly twice the return on assets relative to the processors. Furthermore, the fishers’ cash flow margin was, on average, more than eight times higher, and their annual growth rate was approximately 70% above the corresponding figures of the processing industry. This study argues that the two industries’ performance differences are related to the variations in their institutional setups. The processing industry is subject to the general Norwegian business environment, whereas the fish harvesting industry benefits from a sector-specific framework that supports its relative competitiveness. The fishers have collectively established a legally supported sales organization, thereby strengthening their bargaining power, vis-à-vis the processors (buyers). The fishers’ rivalry is curbed by catch share regulations, and incumbent fishers are protected from intruders through entry barriers, for example, license requirements. Moreover, the processing industry’s potential threat to vertically integrate upstream into the fish harvesting industry is blocked through legislation. Finally, in contrast to the processing industry, the fish input cost is free for the harvesting industry. This study concludes that the fish harvesting industry has gained a sustained competitive advantage over the processing industry, based on a more supportive industry-specific institutional framework.
Aboveground and Belowground Plant Traits Explain Latitudinal Patterns in Topsoil Fungal Communities From Tropical to Cold Temperate Forests
Authors: Teng Jialing , Tian Jing , Barnard Romain , Yu Guirui , Kuzyakov Yakov , Zhou Jizhong
Published: June 2021

Soil fungi predominate the forest topsoil microbial biomass and participate in biogeochemical cycling as decomposers, symbionts, and pathogens. They are intimately associated with plants but their interactions with aboveground and belowground plant traits are unclear. Here, we evaluated soil fungal communities and their relationships with leaf and root traits in nine forest ecosystems ranging from tropical to cold temperate along a 3,700-km transect in eastern China. Basidiomycota was the most abundant phylum, followed by Ascomycota, Zygomycota, Glomeromycota, and Chytridiomycota. There was no latitudinal trend in total, saprotrophic, and pathotrophic fungal richness. However, ectomycorrhizal fungal abundance and richness increased with latitude significantly and reached maxima in temperate forests. Saprotrophic and pathotrophic fungi were most abundant in tropical and subtropical forests and their abundance decreased with latitude. Spatial and climatic factors, soil properties, and plant traits collectively explained 45% of the variance in soil fungal richness. Specific root length and root biomass had the greatest direct effects on total fungal richness. Specific root length was the key determinant of saprotrophic and pathotrophic fungal richness while root phosphorus content was the main biotic factor determining ectomycorrhizal fungal richness. In contrast, spatial and climatic features, soil properties, total leaf nitrogen and phosphorus, specific root length, and root biomass collectively explained >60% of the variance in fungal community composition. Soil fungal richness and composition are strongly controlled by both aboveground and belowground plant traits. The findings of this study provide new evidence that plant traits predict soil fungal diversity distribution at the continental scale.
Functional Hyperconnectivity and Task-Based Activity Changes Associated With Neuropathic Pain After Spinal Cord Injury: A Pilot Study
Authors: Black Shana R. , King Jace B. , Mahan Mark A. , Anderson Jeffrey , Butson Christopher R.
Published: June 2021

Neuropathic pain (NP) is a devastating chronic pain condition affecting roughly 80% of the spinal cord injury (SCI) patient population. Current treatment options are largely ineffective and neurophysiological mechanisms of NP are not well-understood. Recent studies in neuroimaging have suggested that NP patients have differential patterns of functional activity that are dependent upon the neurological condition causing NP. We conducted an exploratory pilot study to examine functional activation and connectivity in SCI patients with chronic NP compared to SCI patients without NP. We developed a novel somatosensory attention task to identify short term fluctuations in neural activity related to NP vs. non-painful somatosensation using functional magnetic resonance imaging (fMRI). We also collected high-resolution resting state fMRI to identify connectivity-based correlations over time between the two groups. We observed increased activation during focus on NP in brain regions associated with somatosensory integration and representational knowledge in pain subjects when compared with controls. Similarly, NP subjects showed increased connectivity at rest in many of the same areas of the brain, with positive correlations between somatomotor networks, the dorsal attention network, and regions associated with pain and specific areas of painful and non-painful sensation within our cohort. Although this pilot analysis did not identify statistically significant differences between groups after correction for multiple comparisons, the observed correlations between NP and functional activation and connectivity align with a priori hypotheses regarding pain, and provide a well-controlled preliminary basis for future research in this severely understudied patient population. Altogether, this study presents a novel task, identifies regions of increased task-based activation associated with NP after SCI in the insula, prefrontal, and medial inferior parietal cortices, and identifies similar regions of increased functional connectivity associated with NP after SCI in sensorimotor, cingulate, prefrontal, and inferior medial parietal cortices. This, along with our complementary results from a structurally based analysis, provide multi-modal evidence for regions of the brain specific to the SCI cohort as novel areas for further study and potential therapeutic targeting to improve outcomes for NP patients.
Task Construal Influences Estimations of the Environment
Authors: Keric Vjeran , Sebanz Natalie
Published: June 2021

People’s characteristics can affect their perception of the physical environment, and the judgments and estimates they make about their surroundings. Estimates of the environment change based on observers’ metabolic state, physical properties, and the potential effort they would need to exert for a certain action. The functional role of such scaling is to provide agents with information on possible actions and their energetic costs. Combining actions with costs facilitates both higher-level planning (e.g., choosing an optimal running speed on a marathon) as well as planning on lower levels of an action hierarchy, such as determining the best movement trajectories for energy-efficient action. Recently, some of the findings on reported effects of effort on perception have been challenged as arising from task demands—participants guessing the purpose of the experimental manipulation and adjusting their estimates as a result. Arguably however, the failed replications used overly distracting cover stories which may have introduced task demands of their own, and masked other effects. The current study tested the generality of effects of potential effort on height and distance perception, employing effective yet not distracting cover stories. Four experiments attempted to identify conditions under which anticipated effort may systematically change perceptual estimates. Experiment 1 found that height estimates were not influenced by the effort required to place objects of different weights onto surfaces of varying heights. Experiments 2, 3 used two different effort manipulations (walking vs. hopping; and carrying an empty vs. a heavy backpack, respectively) and found that these did not influence estimates of distance (to be) traveled. Experiment 4 also used backpack weight to manipulate effort but critically, unlike Exp. 1–3 it did not employ a cover story and participants did not traverse distances after giving estimates. In contrast with the first three experiments, distances in the final experiment were estimated as longer when participants were encumbered by a backpack. Combined, these results suggest that the measured effects on the estimation of distance were due to how participants construed the task rather than being of a perceptual nature.
Probiotics as Adjunctive Treatment for Patients Contracted COVID-19: Current Understanding and Future Needs
Authors: Peng Jiangying , Zhang Meng , Yao Guoqiang , Kwok Lai-Yu , Zhang Wenyi
Published: June 2021

The coronavirus disease 2019 (COVID-19) is caused by a novel coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which rages all over the world and seriously threatens human life and health. Currently, there is no optimal treatment for COVID-19, and emerging evidence found that COVID-19 infection results in gut microbiota dysbiosis. The intestinal microbial richness of patients of COVID-19 does not return to normal levels even six months after recovery, but probiotic adjunctive treatment has been found to restore gut homeostasis. An updated PubMed search returned four finished clinical trials that supported the use of probiotics as adjunctive treatment for COVID-19, while at least six clinical trials aiming to investigate beneficial effects of probiotic intake in managing COVID-19 are currently in progress worldwide. Here in we tentatively summarized the understanding of the actions and potential mechanisms of probiotics in the management of COVID-19. We also highlighted some future needs for probiotic researchers in the field. The success in using probiotics as adjunctive treatment for COVID-19 has expanded the scope of application of probiotics, meanwhile deepening our knowledge in the physiological function of probiotics in modulating the gut-lung axis.
Laparoscopic Radical Hysterectomy Results in Higher Recurrence Rate Versus Open Abdominal Surgery for Stage IB1 Cervical Cancer Patients With Tumor Size Less Than 2 Centimeter: A Retrospective Propensity Score-Matched Study
Authors: Chen Xiaoyue , Yu Jiangtao , Zhao Hongqin , Hu Yan , Zhu Haiyan
Published: June 2021

Objective

To compare the oncologic outcomes between laparoscopic and open radical hysterectomy in patients with stage IB1 cervical cancer lesion less than 2 cm.

Methods

Patients diagnosed FIGO (2009) stage IB1 (tumor diameter <2 cm) and underwent radical hysterectomy in our hospital between March 2008 and November 2018 were studied. A propensity-matched comparison (1:2) was conducted to minimize selection biases. Demographic and baseline oncologic characteristics were balanced between groups. Overall survival (OS) and disease-free survival (DFS) were assessed using the Kaplan–Meier model, along with univariable and multivariable regression analysis.

Results

A total of 261 patients were enrolled in this study after propensity-matching, with 174 in the open group and 87 in the laparoscopic group. Disease relapsed in seven patients in laparoscopy group, and the recurrence rate was 8.0% (7/87). There were eight patients underwent abdominal radical hysterectomy experienced recurrence, and the recurrence rate was 4.6% (8/174). The multivariate analysis model revealed that laparoscopic operation was associated with higher risk of recurrence than abdominal radical hysterectomy (HR, 3.789; 95% CI, 1.143–12.559; p = 0.029). There were five patients or 2.9% (5/174) died in open surgery group and the corresponding percentage in laparoscopy group was 2.3% (2/87). No difference was found in OS between the two groups (HR, 1.823; 95% CI, 0.2673–12.44; log-rank p = 0.5398). All the recurrence occurred within two years after operation in the laparoscopy group, among which pelvic recurrence (85.7%) was dominant.

Conclusion

Traditional laparotomy radical hysterectomy has a lower recurrence rate when compared with laparoscopic operation in those cervical cancer patients with a foci diameter less than 2 cm. However, no detrimental effect on survival was found in minimal invasive operation group. Further multi-center prospective trials are needed to confirm our results on a large scale.
Survival in Patients With Metastatic Prostate Cancer Undergoing Radiotherapy: The Importance of Prostate-Specific Antigen-Based Stratification
Authors: Tian Zijian , Meng Lingfeng , Wang Xin , Wang Xuan , Ma Tianming , Wang Miao , Zhong Qiuzi , Zhang Yaqun , Liu Ming
Published: June 2021

Objectives

To explore the effectiveness of radiotherapy in mPCa patients with different PSA stratifications based on the cancer database of a large population.

Background

Screening criteria for patients with metastatic prostate cancer, who are candidates for radiotherapy, are rarely reported.

Patients and Methods

We identified 22,604 patients with metastatic prostate cancer in the Surveillance, Epidemiology, and End Results database and divided them into a radiotherapy group and a control group. Patients with metastatic prostate cancer were divided into subgroups according to their levels of prostate-specific antigen to evaluate the efficacy of radiotherapy. They were also divided into six subgroups according to their prostate-specific antigen levels. We used multivariate Cox analysis to evaluate overall survival and cancer-specific survival. After 1:1 propensity score matching, Kaplan-Meier analysis was used to explore the difference in overall survival and cancer-specific survival in the radiotherapy and control group.

Results

In all, 5,505 patients received radiotherapy, compared to 17,099 in the control group. In the multivariate Cox analysis, radiotherapy improved overall survival (hazard ratio [HR]: 0.730, 95% confidence interval [CI]: 0.636–0.838; P<0.001) and cancer-specific survival (HR: 0.764, 95% CI: 0.647–0.903; P=0.002) in patients with a PSA level of 4–10 ng/mL. Similar results were obtained by Kaplan-Meier analysis after 1:1 propensity score matching. In patients with prostate-specific antigen levels between 4–10 ng/mL, the overall survival (P<0.001) and cancer-specific survival (P<0.05) in the radiotherapy group was significantly better than those in the control group.

Conclusion

The result of this large population-based study shows that rigorous selection of appropriate metastatic prostate cancer patients for radiotherapy can benefit prognosis significantly. This can be the basis for future prospective trials.
A Rare Case of a Congenital Nasopharyngeal Ganglioglioma With Dyspnea in a 1-Month-Old Male Infant: A Case Report
Authors: Zhao He , Cao Zhiwei , Gu Zhaowei
Published: June 2021

Background: A ganglioglioma (GG), a tumor with both neuronal and astrocytic components, rarely occurs outside the central nervous system.

Case Summary: We present the first reported case of a 1-month-old male with a congenital nasopharyngeal GG, nasal congestion, and dyspnea; we include the operative video. Magnetic resonance imaging was used to explore whether the tumor communicated with the intracranial space. We used an endoscopic plasma technique to ensure complete tumor resection. This afforded a good visual field, endoscopic magnification, and good hemostasis.

Conclusions: We report a rare case of a nasopharyngeal GG triggering nasal congestion and dyspnea in a 1-month-old male, and report our experience with the treatment of nasopharyngeal GG and similar diseases.
Acute Effects on the Human Peripheral Blood Transcriptome of Decompression Sickness Secondary to Scuba Diving
Authors: Magri Kurt , Eftedal Ingrid , Petroni Magri Vanessa , Matity Lyubisa , Azzopardi Charles Paul , Muscat Stephen , Pace Nikolai Paul
Published: June 2021

Decompression sickness (DCS) develops due to inert gas bubble formation in bodily tissues and in the circulation, leading to a wide range of potentially serious clinical manifestations. Its pathophysiology remains incompletely understood. In this study, we aim to explore changes in the human leukocyte transcriptome in divers with DCS compared to closely matched unaffected controls after uneventful diving. Cases (n= 7) were divers developing the typical cutis marmorata rash after diving with a confirmed clinical diagnosis of DCS. Controls (n= 6) were healthy divers who surfaced from a ≥25 msw dive without decompression violation or evidence of DCS. Blood was sampled at two separate time points—within 8 h of dive completion and 40–44 h later. Transcriptome analysis by RNA-Sequencing followed by bioinformatic analysis was carried out to identify differentially expressed genes and relate their function to biological pathways. In DCS cases, we identified enrichment of transcripts involved in acute inflammation, activation of innate immunity and free radical scavenging pathways, with specific upregulation of transcripts related to neutrophil function and degranulation. DCS-induced transcriptomic events were reversed at the second time point following exposure to hyperbaric oxygen. The observed changes are consistent with findings from animal models of DCS and highlight a continuum between the responses elicited by uneventful diving and diving complicated by DCS. This study sheds light on the inflammatory pathophysiology of DCS and the associated immune response. Such data may potentially be valuable in the search for novel treatments targeting this disease.
Rapid Body-Wide Transcriptomic Turnover During Rhesus Macaque Perinatal Development
Authors: Zhang Wenqian , Wang Wei , Zhao Manman , Turck Christoph W. , Zhu Ying , Wang Guang-Zhong
Published: June 2021

An hourglass cup-shape pattern of regulation at the molecular level was detected during the development of the primate brain. Specifically, a peak of temporally differentially expressed genes around the time of birth has been observed in the human brain. However, to what extend this peak of regulation exists among species has not been investigated in great detail. Here, by integrating multiple large-scale transcriptome data from rhesus macaques, we confirmed that a similar differential expression peak exists during the development of the macaque brain. We also found that a similar peak exists during the development of other organs, such as liver, testis, kidney and heart. Furthermore, we found that distinct pathways are regulated in the peak period of those organs. Our results highlight the importance of co-evolution of diverse organs during critical periods of perinatal development in primates.
Feasibility of Reducing and Breaking Up University Students' Sedentary Behaviour: Pilot Trial and Process Evaluation
Authors: Castro Oscar , Vergeer Ineke , Bennie Jason , Biddle Stuart J. H.
Published: June 2021

Background:Accumulating high levels of sedentary behaviour has been linked to poor health outcomes. This study examined the feasibility and preliminary, short-term effects of a theory-based intervention aimed at reducing total and prolonged sedentary behaviour in University students.

Design:A quasi-experimental (pre-post) pilot study. Methods: Nine ambulatory undergraduate students (Mean age = 22 ± 2.32) participated in a one-on-one session, including an educational component around the health effects of sedentary behaviour and three distinct activities (feedback, “pros and cons” exercise, and suggested behaviour change strategies). In addition, automated daily text messages targeting sedentary behaviour were sent for 6 days (four messages per day at fixed intervals). The Behaviour Change Wheel framework guided the intervention design process. Outcomes were assessed over 6 days in pre- and post-intervention periods and included accelerometer-based (activPAL) and self-reported (Nightly-Week-U) total sedentary time, as well as accelerometer-based number of steps and prolonged sedentary time. Students completed a process evaluation interview upon completing the trial.

Results:From pre- to post-intervention, there was a significant reduction in accelerometer-based total and prolonged sedentary time during weekend days. In addition, there was a significant increase in accelerometer-based standing time and stepping during weekend days. There were no statistically significant changes in accelerometer-based sedentary time, standing time or number of steps during weekdays. Process evaluation results indicated that the intervention and its assessment is feasible. Reductions in sedentary time were likely to be mediated by positive changes in the student's reflective and automatic motivation.

Conclusions:Findings from this small, short-term intervention suggest that a single one-on-one session, together with automated text messages, may help University students reduce sedentary behaviour and enhance movement during weekend days. Additional strategies to maximise the intervention effects are discussed (e.g., establishing a collaboration with University staff, introducing sit-to-stand desks, and/or facilitating social support). A randomised control trial assessing sedentary behaviour over a longer period is needed to adequately study the intervention's effectiveness.
Integration of a Passive Exoskeleton and a Robotic Supernumerary Finger for Grasping Compensation in Chronic Stroke Patients: The SoftPro Wearable System
Authors: Salvietti Gionata , Franco Leonardo , Tschiersky Martin , Wolterink Gerjan , Bianchi Matteo , Bicchi Antonio , Barontini Federica , Catalano Manuel , Grioli Giorgio , Poggiani Mattia , Rossi Simone , Prattichizzo Domenico
Published: June 2021

Upper-limb impairments are all-pervasive in Activities of Daily Living (ADLs). As a consequence, people affected by a loss of arm function must endure severe limitations. To compensate for the lack of a functional arm and hand, we developed a wearable system that combines different assistive technologies including sensing, haptics, orthotics and robotics. The result is a device that helps lifting the forearm by means of a passive exoskeleton and improves the grasping ability of the impaired hand by employing a wearable robotic supernumerary finger. A pilot study involving 3 patients, which was conducted to test the capability of the device to assist in performing ADLs, confirmed its usefulness and serves as a first step in the investigation of novel paradigms for robotic assistance.
The Macroscopic and Radiographic Skull and Dental Pathology of the Tasmanian Devil (Sarcophilus harrisii)
Authors: Landy Shanna , Peralta Santiago , Vogelnest Larry , Fiani Nadine
Published: June 2021

While the gross skull and dental morphology, masticatory biomechanics, dental eruption patterns, and radiographic dental anatomy has been described in the Tasmanian devil (Sarcophilus harrisii), to date no studies have comprehensively examined the prevalence and appearance of pathologic processes affecting their skulls and dentition. As such, the aim of this study was to describe macroscopic and radiographic anatomy and identify the prevalence of anatomic variations and pathological processes in Tasmanian devil dentition and skulls. To do so, anatomical and pathological findings were documented in Tasmanian devil skulls using photography and dental radiography. Assessment of skull trauma, anatomical and developmental abnormalities, periodontitis, endodontic disease, and tooth resorption was performed. A total of 28 Tasmanian devil skulls containing 1,028 teeth were examined. Evidence of postmortem trauma was common. The most common positional abnormality was palatal or buccal rotation of the premolar teeth. While the alveolar bone margin was commonly positioned apically to the cementoenamel junction (98.2%), only 14.2% demonstrated evidence of periodontitis. Tooth fractures were common, affecting 27 skulls, however radiographic signs of endodontic disease were only noted in 4.5% of affected teeth, as was non-inflammatory root resorption (2.0%). A wider root canal width, which was used as a criterion for age determination, was associated with smaller skull dimensions, incompletely erupted teeth, and subjectively less fusion of the mandibular symphysis. Through an improved understanding of what constitutes normal anatomy and the appearance and frequency of pathologic processes that affect the skulls and teeth, this knowledge can help develop a foundation for understanding the oral health and management of live animals for this endangered species.
Investigating the Effect of Uncertainty Characteristics of Renewable Energy Resources on Power System Flexibility
Authors: Min Changgi
Published: June 2021

This study investigates the effect of uncertainty characteristics of renewable energy resources on the flexibility of a power system. The more renewable energy resources introduced, the greater the imbalance between load and generation. Securing the flexibility of the system is becoming important to manage this situation. The degree of flexibility cannot be independent of the uncertainty of the power system. However, most existing studies on flexibility have not explicitly considered the effects of uncertainty characteristics. Therefore, this study proposes a method to quantitatively analyze the effect of uncertainty characteristics on power system flexibility. Here, the uncertainties of the power system indicate the net load forecast error, which can be represented as a probability distribution. Of the characteristics of the net load forecast error, skewness and kurtosis were considered. The net load forecast error was modeled with a Pearson distribution, which has been widely used to generate the probability density function with skewness and kurtosis. Scenarios for the forecast net load, skewness, and kurtosis were generated, and their effects on flexibility were evaluated. The simulation results for the scenarios based on a modified IEEE-RTS-96 revealed that skewness is more effective than kurtosis. The proposed method can help system operators to efficiently respond to changes in the uncertainty characteristics of renewable energy resources.
Probabilistic Design of Retaining Wall Using Machine Learning Methods
Authors: Mishra Pratishtha , Samui Pijush , Mahmoudi Elham
Published: June 2021

Retaining walls are geostructures providing permanent lateral support to vertical slopes of soil, and it is essential to analyze the failure probability of such a structure. To keep the importance of geotechnics on par with the advancement in technology, the implementation of artificial intelligence techniques is done for the reliability analysis of the structure. Designing the structure based on the probability of failure leads to an economical design. Machine learning models used for predicting the factor of safety of the wall are Emotional Neural Network, Multivariate Adaptive Regression Spline, and SOS–LSSVM. The First-Order Second Moment Method is used for calculating the reliability index of the wall. In addition, these models are assessed based on the results they produce, and the best model among these is concluded for extensive field study in the future. The overall performance evaluation through various accuracy quantification determined SOS–LSSVM as the best model. The obtained results show that the reliability index calculated by the AI methods differs from the reference values by less than 2%. These methodologies have made the problems facile by increasing the precision of the result. Artificial intelligence has removed the cumbersome calculations in almost all the acquainted fields and disciplines. The techniques used in this study are evolved versions of some older algorithms. This work aims to clarify the probabilistic approach toward designing the structures, using the artificial intelligence to simplify the practical evaluations.
Interactions and Binding Energies in Carbon Nanotube Bundles
Authors: Rybolt Thomas , Jordan Heir
Published: June 2021

On any size scale, it is important to know how strongly structural components are held together. The purpose of this work was to develop a means to estimate the collective binding energy holding together a bundle of aligned carbon nanotubes (CNTs). Carbon nanotubes in isolation and in bundles have unique and useful properties and applications within supramolecular structures and nanotechnology. Equations were derived to represent the total number of pairwise interactions between the CNTs found in various size and shape bundles. The shapes considered included diamond, hexagon, parallelogram, and rectangle. Parameters were used to characterize the size of a bundle for each defined shape. Force field molecular modeling was used to obtain the total bundle binding energies for a number of sample bundles. From the number of interactions per bundle, the binding energy per interaction was determined. This process was repeated for armchair CNTs having a range of length and circumference values. A simple equation described the interaction energy based on the length and circumference of the component armchair type nanotubes. When combined with the bundle shape and size parameters, the total bundle binding energy could be found. Comparison with whole bundle molecular mechanics calculations showed our formula-based approach to be effective.
Geometric Influence of Hard Phase on Corrosion Performance between WC-Reinforced Coatings Prepared by High-Velocity Oxygen-Fuel Spray and Electric Contact Strengthening
Authors: Sun Ze , Zhu Shigen , Dong Weiwei , Ding Hao , Bai Yunfeng , Luo Yilan , Di Ping
Published: June 2021

Several kinds of WC-reinforced coatings were prepared by high-velocity oxygen-fuel spray (HVOF) and electric contact strengthening (ECS), respectively, and their corrosion behaviors in 3.5% NaCl solution were investigated. The microstructure, element distribution, phase and corrosion resistance of these coatings were compared. The results showed that, compared with HVOF-sprayed coatings, the ECS-prepared coatings were denser and with lower porosity. Simultaneously, the ECS coatings that used raw powder commercial WC-12Co retained the original spherical geometry of the hard phase. In open-circuit potential measurements, these ECS coatings gave higher stable potentials (Eocp). In potentiodynamic polarization tests, although the corrosion currents (icorr) of the homogeneous coatings were approximately the same, these ECS coatings still exhibited higher corrosion potentials (Ecorr). The spherical geometric distribution of the hard phase led to a bounded diffusion model caused by the diffusion change of corrosion products.
An Innovative System for the Treatment of Rising Dampness in Buildings Located in Cold Climates
Authors: Promis Geoffrey , Douzane Omar , Rousse Daniel R. , Langlet Thierry
Published: June 2021

Signs of wetness in housing are a significant obstacle to the renovation and energy rehabilitation of old and energy-intensive heritage buildings, especially in cold climates. Thus, in order to avoid the numerous possibilities of degradation caused by the moisture transfer phenomena in the building envelope, the a disruptive aeraulic process, which focuses on the ventilation of an air gap between the thermal insulation and the wet wall, has been designed and its assessed. This system avoids the presence of liquid water at the wall surface by maintaining the hygrothermal balance within the wet wall. This enables the mechanical durability of the supporting structure, the absence of biological activity and/or frost and, hence, the durability of the thermal insulation. These issues are investigated through a case study based on a real site. Over a year of measurements, the wet wall was constantly maintained in hygroscopic balance, around 90% RH, guaranteeing the preservation of its mechanical performance, while the insulation layer was kept moisture free. In addition, the proposed model for predicting the appearance and development of biological activity demonstrated its validity, confirming experimental results.These initial results will now lead to the optimization of the aeraulic device, as well as possible use in a summer cooling context to achieve hygrothermal comfort for housing occupants.
Glass Cullet as Additive to New Sustainable Composites Based on Alumina Binder
Authors: Powęzka Aleksandra , Ogrodnik Paweł , Szulej Jacek , Pecio Mariusz
Published: June 2021

The article investigated the possibility of reusing heat resistant glass cullet to improve the mechanical properties of high-temperature composites. This is an excellent recycled aggregate that may be used as a substitute for alumina cement, and for fine natural aggregate in the production of concrete based on hydraulic binder. The experimental programme comprised of strength testing conducted on 40 × 40 × 160 mm cuboidal samples. The model mixture was modified by filler that comprised glass recyclate, amounting to 5%, 10%, and 15% of the mass of gravel and cement. Given the degree of glass grounding, use was made of two fractions, 0/4 and 0/0.125 mm. Six modified mixtures were produced. Tests were then carried out on their selected physical and mechanical properties as well as the impact of temperature, topography, and chemical composition exerted on the composite. Next, the progress and development of compressive strength and flexural strength after 14 and 28 days of curing were studied. Results showed that concrete with a 5% content of glass dust had a maximum compressive strength at the level of 85.1 MPa. Results also showed that concrete (Zk.I.5) heated at a temperature of 500 °C had a 46% higher compressive strength when compared to basic concrete (Z.I.0). The results show that it is possible to use the described components to obtain a composite that meets requirements imposed on structural materials used in construction engineering.