bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptual Framework of Dynamic Scrum Model and Knowledge Management for Software Product Management
Authors: Ahmad  Ammourah Boraq , Ali Pitchay Sakinah
Published: April 2021

Software development methodologies and knowledge management (KM) are a dynamic part of core challenge of the organization in order to deliver on time with less effort and efficient software product. Scrum model is widely known as one of the best common software development methodologies and this paper has conducted a survey on how to transfer the knowledge between team members. Moreover, the Scrum model relies on daily stand-up meeting or daily scrum meeting for capture and share knowledge. Thus, this paper investigates Scrum model and knowledge management process on how to improve the proficiency of knowledge sharing among the software practitioners with less time and effort. It also proposes a conceptual framework where it stores and retrieves the tacit knowledge via Scrum model for software product management. This proposed conceptual framework is used to store and retrieve the tacit knowledge via Scrum process for software product management to save a time consuming and effort.
Synthesis and Characterization of Magnetic Nanoparticles (MNP) and MNP-Chitosan Composites
Authors: Asey Monica Namizie , Mohd Esa Norhaizan , Che Abdullah Che Azurahanim
Published: April 2021

Coating of iron oxide nanoparticles (MNP) is the common approach to reduce the effects of direct toxicity due to the ion oxidation that lead to the damage of DNA. This study investigates the effect of different concentration of Chitosan (Cs) used to coat the magnetic nanoparticle with variation in the crystallite size, chemical bonding, changes in weight and surface morphology. From the XRD results, it shows that the sample 1MNP-1Cs has optimum size of 13.42 ± 0.01 nm. From the FTIR analysis, it is revealed that there are three types of chemical bonding that occur in the MNP-Cs composites which are stretching vibrations of C-H, N–H vibration belonging to Cs and the Fe-O bonds from the MNP. From the FESEM analysis, it is found that the MNP-Cs composites have a wellshaped with spherical in form, as well as, smooth surfaces. As for TGA, the thermal decomposition of MNP nanocomposites was based on the amount of Cs and MNP used to produce the nanocomposites. Further studies will be conducted to find the optimum ratio of MNP-Cs for anticancer drug delivery application.
The Diet Problem on Minimizing Vitamin A: Linear Programming Problem
Authors: Ruslan Muhammad Naim , Mohamed Nurul Farihan
Published: April 2021

It is essential to practice a good diet in everyday life because human body needs a reasonable amount of nutrients. It is because excessive nutrient intake can lead to internal organs failure, such as kidney damage. This study focuses on minimizing vitamin A’s intake in daily diet because vitamin A can give good vision, maintain healthy skin, and improve body's immune system. This research involves a few nutrients, such as calcium, iron, cholesterol, and vitamin A. The diet problem of minimizing vitamin A will be solved by using the graphical method and excel solver. The results are compared to determine which ways is the best. The results obtained are optimal solution, which is the minimal amount of vitamin A from one of the methods.
Biogenic Amines as Freshness Indicator in Halal and Non-Halal Slaughtered Chicken Meat Using Chromatographic Approach
Authors: Mohd Yusoff Muhammad Nazmin , Jaffri Muhammad Haziq , Azhari Syaza
Published: April 2021

Biogenic amines are naturally occurring organic bases produced by bacterial decarboxylation of amino acids that have been associated with harmful toxicology effects to humans. The main objective of this work is to investigate the possible role of biogenic amines (BAs) as indicators of spoilage in fresh chicken meat stored at 4°C for 15 days. A reversed-phase high-performance liquid chromatographic method with isocratic elution system is used for the quantification of four biogenic amines (putrescine, histamine, tyramine, cadaverine and spermine as well as spermidine) in chicken meat. Amines were extracted with 5% of trichloroacetic acid (TCA) and derivatised using dansyl chloride. The variation storage time differentiated the chicken meat on the microbiological characteristics. The results obtained shows that histamine, spermidine, tyramine, cadaverine, and putrescine increased slowly while spermine decreased for both chicken breast in halal and non-halal chicken meat. Thus, this BAs could be used as a spoilage index of fresh chicken meat.
A Systematic Review on The Insurability Risk for Long-Term Care Insurance in Europe and Asia Countries
Authors: Arshad Nurin Amni , Md Yusuf Mazlynda
Published: April 2021

Due to the trends of the increase in life expectancies and decrement in fertility rates, the world population is moving towards becoming an ageing nation. With the rise in the number of older people, the demand for long-term care services is expected to increase. Long-term care services are ubiquitous in the developed country, especially in the European region as the countries have become the aged nations. Apart from that, the cost for long-term care services differs for individuals based on the level of needs and the service provider, either public or private nursing home for long-term care. Due to the growing cost of long-term care services, a long-term care insurance policy may be seen as an alternative to covering the cost of long-term care services because the risk is mitigated for individuals. However, most Asian countries are not familiar with the long-term care insurance policy as there is no specific insurance policy for long-term care services offered yet in these countries. The essential factor in constructing a long-term care insurance policy is to identify the risks that are insurable to be included in the policy to be used later for pricing long-term care insurance policy in Malaysia. This study provides an in-depth review and understanding of the insurable risks associated with long term care insurance in European and Asian countries.
Factors Influencing the Purchase Decision of Affordable Housing Among Middle Income Earner: A Case Study of School teachers in Malaysia
Authors: Ismail Shahrina , Syed Mohamad Sharifah Fairuz
Published: April 2021

Affordable housing is a significant issue that has been a concern among Malaysians nowadays, especially in the middle-income group. The demand for housing has been increasing, and thus, the preferences of this group must be taken into consideration. The focus of this study is to identify the factors influencing house buyers in purchasing affordable housing among middle-income groups. The data was collected through a questionnaire survey distributed among school teachers in Malaysia. Two hundred twenty-five respondents returned the questionnaire, which was used for data analysis. Descriptive and statistical analysis was performed to analyze the data collected using Minitab software, Microsoft Excel, and Statistical Package for Social Science (SPSS). It revealed that house prices, location, and structure of housing had a significant relationship with the purchase decision of affordable housing among the middle-income group. In contrast, the neighbourhood factor had an insignificant relationship. It is also found that middle-income groups are aware of Malaysia’s affordable housing scheme and have a chance to be exposed to the scheme. Thus, this research will help the developers in developing housing schemes based on consumer’s orientation for future demand in Malaysia.
建设无氢、油、氨本质安全型燃煤机组的实践与探索
Authors: 董 彬 , 鲁 凤鹏 , 张 开崇 , 杨 成余 , 周 杰
Published: April 2021

以某350MW超临界燃煤火电机组为例，通过研究其如何按照本质安全型企业的标准推进项目建设，从提高企业环境安全可靠性着手，控制存在于生产作业中的危险源，降低现场作业环境的各种风险；燃煤机组取消氢站、柴油罐、氨区,可以减少企业内部重大危险源数量，助力本质安全型企业建设；同时有利于电力企业减少土地使用面积；取消氢站、燃油库，可以降低发电企业建设成本，减少发电企业经营、维护成本。本篇文章以通过调查研究，得出建成“无氢、无油、无氨”电力企业的必要条件，使建成“无氢、无油、无氨”电力企业具有可复制性，为350MW机组优化先型建设提供参考，提升350MW燃煤机组本质型安全环境。
水利工程质量检测方法思考
Authors: 王 影
Published: April 2021

水利工程建设利国利民，这些年我国在水利工程建设领域的投入力度不断加大，大量的水利工程项目开始建设。为了确保水利工程质量，需要加强质量检测，采用合适的检测方法来发现质量问题，并加以改进。目前水利工程质量检测水平整体偏低，远远满足不了水利工程建设的需要。文章首先对水利工程质量检测的重要意义从不同维度进行了探讨，随后总结分析了目前水利工程质量检测领域存在的典型问题，最后围绕文中所谈到的各种问题，提出了具体的解决办法。
无损检测技术在水利工程中的应用研究
Authors: 于 小红
Published: April 2021

在科学技术飞速发展的影响下，大量的新兴科技被研发出来，并且被人们大范围的运用到了诸多领域之中，取得了良好的成绩，在这种发展形势下我国无损检测技术整体水平得到了良好的发展。将无损技术实践运用到水利工程施工建造之中，不但可以促进工程施工效率的显著提升，并且还能够对施工安全保障起到积极的辅助作用。鉴于此，这篇文章主要围绕无论检测技术在水利工程实践施工过程的运用展开全面深入的研究分析，希望能够对我国社会和谐稳定发展有所帮助。
自动化技术在电力工程中的应用
Authors: 赵 娜
Published: April 2021

伴随经济的迅速发展，电力工程所发挥的作用显得越来越重要，而电力工程电气自动化技术的运用也是更加熟练，作为高新技术的重要代表，电气自动化技术主要包括了两个方面，即电气设备的应用以及电力技术的应用。通过电气自动化技术能够在很大程度上提高电力工程的运行质量和运行效率，对推动我国电力工程行业健康迅速的发展有着至关重要的意义。因此在文章中我们主要对自动化技术在电力工程中的应用进行了详细的分析与探讨，以供参考。
水库运行管理及调度的有效方法研究
Authors: 朱 芳芳
Published: April 2021

在人类社会快速发展的过程中，水资源的作用是非常重要的，不管是社会发展还是民众的生活都离不开水资源，而就实际情况来说，水资源分布不均匀的问题越发凸现出来，从而对社会发展造成了很大的制约。水库管理以及调度工作是保证农业和工业生产的重要基础，并且水库在蓄洪、防洪工作中也具有十分重要的影响。但是就当下实际情况来说，水库管理和调度工作整体水平还没有达预期的目的，其中还存在诸多的问题需要我们加以切实的解决。
电力系统电气工程自动化的智能化的应用
Authors: 黄 大立
Published: April 2021

近年来，在多方面利好因素的影响下，我国各个领域都得到了全面的发展进步，在这种发展形势下，社会的发展和民众的生活对于电力能源的需求量在不断的增加，这样就对我国电力系统的运行情况提出了更高的要求。电力系统其实质就是利用输电技术、发电技术以及配电技术完成电能生产、传输的系统，其能够将生态环境中的能源利用专业的发电装置转变为电能，随后传输到需要的用户。由于电源点通常都被设置在不同的区域，所以不能加以大量的存储，这就需要确保发电与用电二者维持良好的平衡性。电力系统要想确保为用户提供稳定的优质电能，那么最为重要的就是需要从各个细节入手来进行全面的管控，这样才能不断提升电能的使用效率。在工业生产稳步发展的影响下，电气工程自动化整体水平随之逐渐的提升，电气工程自动化的逐渐的成为了当前高新技术产业中的主要部分，并被人们大范围的运用到了诸多领域之中，取得了良好的成绩，在推动社会经济发展方面起到了积极的影响作用。
农村水厂微污染水处理工艺设计与研究
Authors: 王 金松
Published: April 2021

农村饮水安全工程建设，取得了巨大的社会效益和经济效益，深受农民的欢迎，被誉为“德政工程”、“民心工程”。饮水安全事关亿万农民的切身利益，是农村群众最关心、最直接、最现实的利益问题。近年来饮用水水源地水环境形势不容乐观，水污染事件时有发生，直接影响到农村饮用水安全。文章针对水库地表水水体富营养化污染事件，采用的深度处理技术方案。
浅析自动化系统在水情测报中的应用
Authors: 克力木 阿力木江 •
Published: April 2021

文章主要针对现阶段精河地区的水情自动测报系统进行详细的研究，以此有效的为其计算及自动化系统进行详细的设计以及运算。在这样合理的系统运作的过程中，可以有效的帮助工作人员合理的进行数据采集以及分析，进而可以有效的在水情自动测报系统当中，形成良好的检测效果。
浅谈水利施工中软土地基处理的方法
Authors: 陈 海兵
Published: April 2021

近年来，在多方面利好因素的影响下，我国综合国力得到了全面的发展进步，从而为各个领域的发展壮大创造了良好的基础。在这种发展形势下，无论是各个行业的运营生产还是民众正常生活对于水力资源的需求量不断的增加，这样就对水利工程建设工作提出了更高的要求。水利工程建设工作具有较强的特殊性，通常水利工程都会被建造在水资源较为丰富的地区，并且极易遇到软土地基的情况，为了能够从根本上对水利工程施工质量加以保证，那么就需要我们增强对水利工程软土地基处理工作的研究，为整个水利工程行业的稳步健康发展创造良好的基础。
Taking Highly Palatable Food or Naively Consuming Fatal Toxic Diet
Authors: Dutta Siddhartha , Haque Mainul
Published: April 2021

Abstract not available

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.478-482
Anxiety Disorders: Recent Global Approach to Neuro-pathogenesis, Drug Treatment, Cognitive Behavioral Therapy, and Their Implications
Authors: Abubakar Abdullahi Rabiu , Sani Ibrahim Haruna , Malami Sani , Yaro Abudllahi Hamza , Jahan Iffat , Adnan Nihad , Kumar Santosh , Islam Salequl , Dutta Siddhartha , Charan Jaykaran , Haque Mainul
Published: April 2021

Anxiety is a group of mental disorders characterized by the sudden feeling of intense fear, panic, shortness of breath, chest pain, restlessness, GIT problems, insomnia, fatigue, muscle tension, sweating, loss of memory, blurred vision, and impaired learning. It occurs typically in response to a stressful situation that may become pathological when it is no longer controlled or occurs in the absence of real threat. This review aimed to appraise the literature on the prevalence, classification, neuro-pathogenesis, diagnoses, and treatment of anxiety disorders (AD). The search was made using PubMed, Embase, MEDLINE, and PsycINFO databases. Anxiety disorders are the most common mental disorders affecting humans, especially among developing nations. In general, the lifetime prevalence of AD is about 14%, with an annual prevalence of 31%. Unfortunately, AD, in general, is underdiagnosed and undertreated globally.

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.487-503
Forecasting cumulative COVID-19 cases in Malaysia and rising to unprecedented levels
Authors: W Ahmad Wan Muhamad Amir , Nawi Mohamad Arif Awang , Zainon Wan Mohd Nazlee Wan , Mohd Noor Nor Farid , Mohd Hamzah Firdaus , Mohamad Ghazali Farah Muna , Alam Mohammad Khursheed
Published: April 2021

Background: COVID-19 outbreak is being studied throughout the world. Adding more analysis to date strengthening the information about the illness. Here, we analysis the data of Malaysian Ministry of Health from February 15, 2020 until January 10, 2021 was analysed using linear regression model statistical analysis with aim to forecast the trend.

Materials and Methods: This study reviewed the data by Malaysia Ministry of Health from February 15, 2020, until January 10, 2021. Linear regression model statistical analysis was used for predictive modelling. The forecasting of the linear trend of the Covid-19 outbreak prediction is purposed to estimate the number of confirm cases according to the number of recoveries patients.

Results: Malaysia is currently anticipating another lockdown restriction as new confirmed case of COVID-19 hit new record high. The cumulative confirmed Covid-19 cases in MCO predicted a sharp increase. At the first of March, 2021, the predicted cumulative confirmed Covid-19 cases are 319,477 cases.

Conclusions: Covid-19 cases projected to 315766 by end of February 2021 with 3000- 4000 daily cases predicted. Initiative and proactive measurement by Malaysian government hopefully can reduce the number of cases and flatten the infection curve.

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.504-510
Upper Limb Dysfunction Increases Fear of Falling in People With Stroke
Authors: BİLEK Furkan
Published: April 2021

Objective: Our study was planned to investigate the effect of upper limb function on fear of falling in stroke patients.

Materials and methods: A total of 61 patients, 33 women with chronic hemiplegia or hemiparesis, were included in the study. Patients’ upper limb motor condition was obtained using the Fugl-Meyer Upper Extremity Rating Scale (FMA), upper limb function Arm Motor Ability Test (AMAT) and fear of falling International Fall Efficacy Scale (FES-I). Standard Mini-Mental Examination scale was used to exclude patients with mental disorders.

Results and Discussion: There was a highly significant negative correlation between FES-I and AMAT and FMA scores (p <0.001, r = -0.926 and r = -0.888, respectively). There was also a significant positive correlation between FMA and stroke time (p <0.05). It was observed that the fear of falling with the level of upper limb dysfunction increased in parallel.

Conclusion: It suggests situation that this is due to the fact that they experience balance problems as a result of upper limb dysfunction and when they fail to reveal protective reflexes in a quality way

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.539-542
Auditory Cognitive Function Assessment during Pregnancy: An Event-Related Potential and Neuropsychological Study
Authors: Begum Tahamina , Reza Faruque
Published: April 2021

Objectives: We investigated the auditory cognitive and behavioral functions during 2nd and 3rd trimesters of pregnancy using event-related potentials (ERPs) and different neuropsychology tests, respectively.

Methods: The ERPs were studied by using a 128-sensor net, and PAS/COWA, WCST, ZCT, RAVLTIM/RAVLTDR/RAVLTTS, and BDI were tested for neuropsychology assessment. Total 39 subjects were recruited for control group (G1, n=15, non-pregnant), 2nd trimester group (G2, n=12, 13-26 weeks gestation), and 3rd trimester group (G3, n=12, 26- 40 weeks gestation). Auditory oddball paradigm was used during ERP study. Subjects silently counted only the target stimuli with attention by ignoring standard stimuli. Value of the mean differences of the target and standard stimuli were measured across groups in 10-20 electrode systems.

Results: The P50, N100, and P300 ERP components were analyzed. The G3 (at F7 and C3) and G2 (at T4) groups evoked the highest significant amplitudes in P50, and G3 (at Cz and Pz) and G1 (at F8 and T4) evoked the highest significant amplitudes of N100 with significantly prolonged latencies at Cz and O1 (in G1) and F8 (in G2). However, significantly higher amplitudes of P300 were found at Fz (in G3) and FP1 (G2) (G2>G3). On the other hand, neuropsychology tests revealed that G2 possessed the highest significant score in WCST and G1 in ZCT. The G3 performed poorly in all tests.

Conclusion: We concluded that pregnant groups performed better in auditory (attention/memory) and executive function assessment. Moreover, the 2nd trimester group has better auditory cognitive function compared to the 3rd trimester group due to the effect of hormonal changes during pregnancy, which might be a positive influence during the pregnancy period.

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.608-617
Kratom Dependence in Adolescents: Is Methadone A Lifesaver?
Authors: Kamaludin Nawal Nabilah , Mohd Noor Mohd Ariff , Muhamad Rosediani , Yudin Zainab Mat , Mohamed Nawi Nur Ilyani
Published: April 2021

Kratom dependence among adolescent, even though underreported, is increasing in prevalence in Southeast Asia. Kratom can be simply misused with a great possible addiction and subsequently cause serious undesirable physical and mental health consequences, which is not something to be taken lightly. We present three case series of late adolescents who consumed kratom for more than six months, which leads to poor school performance and had already developed withdrawal symptoms. This case series illustrates the effectiveness of treating adolescents with kratom dependency using combination of medical therapy - Methadone as Drug Substitution Therapy (DST) and supportive therapy from their family members. Therefore, it is crucial for primary care practitioners to screen the adolescents and alert the withdrawal symptoms as well as initiating early discussion with psychiatrist in order to start the prompt treatment since DST is available in primary care clinic.

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.673-677
A 60-year-old man with isaacs mertens-syndrome a rare entity
Authors: Tharani G , Kamatchi K , Yuvarani G
Published: April 2021

Isaacs-mertens syndrome also known as neuromyotonia is a rare neuromuscular disorder caused by hyperexcitability and continuous firing of axons of the nerve that innervate the muscle fibers. It is an immune-mediated disorder with elevated antibody level against voltage gated potassium channels (VGKC). Symptoms include progressive muscle weakness, continuously twitching muscles (myokymia), cramping, increased sweating and delayed muscle relaxation. This is a case report of a 60-year-old man who presented with pain and weakness of right lower limb for 3 months, which gradually became worse to involve both the lower and upper limbs. NCS revealed to have motor neuropathy and EMG showed fibrillations and fasciculations with positive sharp waves. After which he was diagnosed with Isaacs-mertens syndrome and was followed up for 8 weeks with medications and physiotherapy management.

Bangladesh Journal of Medical Science Vol.20(3) 2021 p.691-693
Analisis Perbandingan Kinerja Investasi Portofolio Pasar Modal Syariah Dengan Pasar Modal Konvensional (Studi Kasus Pada Jakarta Islamic Index dan IDX30)
Authors: Bakri Katti Siti Wardani , Mutmainah Mutmainah
Published: April 2021

Abstractâ€” The general difference between conventional capital markets and Islamic capital markets can see in the instruments and transactio mechanism, while the difference of Sharia stock index value with conventional stock index value lies in the criteria of the issuerâ€™s shares that must meet the basic principles of sharia. The aim of this research is 1) to know average difference of return between Jakarta Islamic Index (JII) with IDX30 in bullish and bearish period, 2) to know the difference of return between Jakarta Islamic Index (JII) with IDX30 in bullish and bearish period through Sharpe Index approach. The research type is explanatory research. This research use all of go public companies on Indonesia Stock Exchange (BEI) from 2014-2018. Sampling in this research use purposive sampling. The classic assumption test uses normality and homogeneity test. Data analysis method use independent sample T-test. The research result show that no average difference of return of portfolio investment performance in the 2014-2018 period between Jakarta Islamic Index (JII) with IDX30 in the bullish and bearish period. Portfolio investment performance in the 2014-2018 period show no average difference of return between Jakarta Islamic Index (JII) with IDX30 through Sharpe index approach in the bullish and bearish period.Â Keywordsâ€”: Islamic Capital Markets; Conventional Capital Markets; Jakarta Islamic Index; IDX30; Indonesia Stock Exchange.
FAKTOR INTERNAL YANG MEMPENGARUHI CYCLE EFFECTIVENESS (CE) PADA PABRIK GULA MADUKISMO
Authors: Hartono Halleina Rejeki Putri
Published: April 2021

This study aims to examine internal environmental factors that can affect the level of Cycle Effectiveness (CE) in the sugar production process at the Madukismo Sugar Factory (PG Madukismo). This research is a qualitative research using descriptive analysis method. The data used in this study are primary data and secondary data. The instrument in this study was an interview question conducted to PG Madukismo regarding internal environmental factors that influenced CE at PG Madukismo. The research data technique used observation techniques, interviews, archival data interviews. The technique of analyzing research data through three stages, namely data reduction (data reduction), data presentation (data presentation), and drawing conclusions and levers (drawing conclusions / verification). The results showed that the internal factors that influenced CE were the activity of measuring sugarcane weight, sugarcane delivery, crystallization and stopping milling. Production processes that have non-value added activities that occur in moving activities, waiting activities, and reworking activities.
Pengaruh PAD, DBH, DAU, dan SiLPA Terhadap Belanja Bantuan Sosial Pada Pemerintah Daerah Se-Bakorwil Madiun
Authors: Wibisono Nurharibnu , Purnomo Herry , Rahaju Endang Edy
Published: April 2021

Abstractâ€” This study aims to examine the effect of the Regional Original Revenue (PAD), the Revenue Sharing Funds (DBH), the General Allocation Fund (DAU), and the Remaining Budget Calculation (SiLPA) on Social Assistance Expenditure (Bansos) in Local Governments as the Madiun Regional Coordination (Bakorwil) both partially and simultaneously. The research objects were 10 (ten) Regional Governments in Bakorwil Madiun, East Java, Indonesia based on the realization of APBD data for the period 2011 - 2018. Multiple linear regression method with the help of SPSS 20 was used as an analytical tool in this study. The results of this study indicate PAD, DBH, and DAU affect the Social Assistance Expenditure in Local Governments as the Madiun Regional Coordination (Bakorwil). Whereas SiLPA has no effect on Local Governments as the Madiun Regional Coordination). Simultaneously shows PAD, DBH, DAU, and SiLPA influences the Social Assistance Expenditure in Local Governments as the Madiun Regional Coordination.Â Keywordsâ€”: Regional Original Revenue; Revenue Sharing Fund; General Allocation Fund; Remaining Budget Calculation; and Social Assistance Expenditure.
Afetividade como prática metodológica na educação infantil: Uma revisão narrativa
Authors: Silva Kaio Germano Sousa da , Santos Nilzete Lima Costa dos , Silva Francisca Thawanny de Souza , Sousa Solange Gonçalves Nunes de , Nascimento Cristiane Dutra do , Primo Conceição de Maria Machado Costa , Silva Saleia Soares Leitão , Sousa Ranna Johara de Cunha Bacelar de Oliveira , Lima Jânio Oliveira , Silva Marta Alves de Oliveira , Mesquita Marise Silva Lima de , Cunha Apollo Habacuque dos Santos , Freitas Simone Neves Queiroz de , Oliveira Christyanne de Jesus Pereira , Melo Karine Costa
Published: April 2021

A afetividade promove transformações na educação, permitindo estimular o prazer durante o aprendizado, favorecendo a criança a uma melhor adaptação ao meio, e torna-se necessário sua inserção como prática pedagógica. O objetivo desse estudo foi investigar a importância da afetividade na educação infantil. Trata-se de uma revisão bibliográfica de cunho narrativa, descritiva e exploratória. A partir da temática “A afetividade como prática metodológica na educação infantil: uma revisão narrativa”, formulou a seguinte questão norteadora: Qual a importância da afetividade como prática metodológica no ensino de crianças? E foram consultados bases dados online de pesquisa tais como ScieLO, ERIC, Google Acadêmico. Ao todo dezenove artigos (19) foram selecionados, conforme os critérios de inclusão e exclusão. Os estudos abordavam sobre os conceitos de afetividade e sua relação com o ensino, a afetividade no contexto familiar, o papel do docente na utilização da afetividade em sala de aula, e a importância da afetividade no ensino da educação infantil para o desenvolvimento e aprendizado das crianças. A afetividade deve ser vista como uma abordagem prática no ensino das crianças como estratégia positiva no processo de aprendizagem, estratégias estas que podem ser desenvolvidas pelo professor no ambiente escolar, e também no âmbito familiar, pois o vínculo entre o aluno e sua família propiciam benefícios quanto a sociabilidade e aprendizagem.
Assistência ao paciente com hipertensão na Atenção Primária à Saúde
Authors: Marques Victor Guilherme Pereira da Silva , Lima Mariel Wágner Holanda , Melo Ana Carla Almeida de , Souza Bruno Santos , Santana Barbara Bispo de , Leal Rodrigo Andrade , Santos Tarcísio Gonçalves de Souza , Santos Marks Passos , Reis Lisandra Santana Oliveira , Santos Aranin Queiroz de Sousa , Loures Leandro Luiz da Silva , Sousa Júnior Célio Pereira de , Oliveira Emanuelly Marinho de , Santos Maria Sinária Silva de Castro dos , Bandeira Camila Almeida , Souza Lorrane Silva de
Published: April 2021

O presente estudo tem como objetivo realizar um levantamento bibliográfico acerca da assistência ao paciente com hipertensão na atenção primária à saúde. Trata-se de uma revisão integrativa da literatura, a busca ocorreu na Biblioteca Virtual em Saúde (BVS), com o auxílio das bases de dados Literatura Latino- Americana e do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO), Base de Dados de Enfermagem (BDENF) e PUBMED. Os artigos foram coletados no período de janeiro a fevereiro de 2021. Foram tilizados os descritores: Atenção primária à saúde, Assistência ao paciente, Hipertensão e Promoção da saúde. Após a aplicação dos critérios de inclusão, restaram 20 estudos. O presente estudo demonstra que é necessário a atuação da equipe multidisciplinar em combate á hipertensão na atenção primária, utilizando de estratégias protocoladas pelo ministério da saúde se destacando a educação em saúde, que por meio das ações realizadas é possível manter o controle da doença em pacientes hipertensos.
Effects of site and tree size on wood density and bark properties of Lebombo ironwood (Androstachys johnsonii Prain)
Authors: Magalhães Tarquinio Mateus
Published: April 2021

Background: Wood and bark are important renewable natural resources. Density is an important property that is used to describe wood and bark quality for a number of end uses. However, wood and bark density, bark proportion and dimensions vary with age and site, as well as among and within trees. The aim of this study was to investigate the effect of site, diameter class, and vertical position within the stem on the density of wood and bark, bark volume, bark dry-mass and thickness of Lebombo ironwood (Androstachys johnsonii Prain).
Methods: The study was conducted on 93 Lemombo ironwood trees growing in Mozambique. Eight discs were sampled from each selected tree and diameter over and under bark was measured. Bark thickness, bark mass and bark density were determined along with the basic wood density of each disc.
Results: The overall average whole-stem properties were estimated at: 786 kg m–3 wood density, 586 kg m–3 bark density, 19% bark volume, 19% bark dry-mass, and 9 mm bark thickness. Height level uniquely explained most of the variation in bark mass (97%), bark volume (95%) and wood density (86%). Diameter class explained most of the variation in bark density (51%) and bark thickness (51%). Site only explained a small proportion of the variation in all dependent variables.
Conclusions: Overall, the patterns of variation of all wood and bark properties were highly dependent on tree diameter class and vertical position within the stem. Site differences were not a significant source of variation in the properties studied. Improved knowledge of the wood and bark properties of this species will aid its sustainable management and utilisation.
Combined effects of ocean acidification and elevated temperature on feeding, growth, and physiological processes of Antarctic krill Euphausia superba
Authors: Saba GK , Bockus AB , Shaw CT , Seibel BA
Published: April 2021

Antarctic krill Euphausia superba is a key species in the Southern Ocean, where its habitat is projected to undergo continued warming and increases in pCO2. Experiments during 2 summer field seasons at Palmer Station, Antarctica, investigated the independent and interactive effects of elevated temperature and pCO2 (decreased pH) on feeding, growth, acid-base physiology, metabolic rate, and survival of adult Antarctic krill. Ingestion and clearance rates of chlorophyll were depressed under low pH (7.7) compared to ambient pH (8.1) after a 48 h acclimation period, but this difference disappeared after a 21 d acclimation. Growth rates were negligible and frequently negative, but were significantly more negative at high (3°C, -0.03 mm d-1) compared to ambient temperature (0°C, -0.01 mm d-1) with no effect of pH. Modest elevations in tissue total CO2 and tissue pH were apparent at low pH but were short-lived. Metabolic rate increased with temperature but was suppressed at low pH in smaller but not larger krill. Although effects of elevated temperature and/or decreased pH were mostly sublethal, mortality was higher at high temperature/low pH (58%) compared to ambient temperature/pH or ambient temperature/low pH (>90%). This study identified 3 dominant patterns: (1) shorter-term effects were primarily pH-dependent; (2) krill compensated for lower pH relatively quickly; and (3) longer-term effects on krill growth and survival were strongly driven by temperature with little to no pH effect.
Clustering Customer Data Using Fuzzy C-Means Algorithm
Authors: Nurfaizah Nurfaizah , Fathuzaen Fathuzaen
Published: April 2021

The pattern of the service industry is influenced mostly by economic growth. When economic growth rises, the economic activity will also grow as in the case of insurance activities. One of the assets owned by an insurance company is the customer, hence the existence of a loyal or potential customer should be maintained by the insurance company. This study focuses on clustering or grouping the existing customer data in insurance companies using the Fuzzy C-Means (FCM) algorithm. This study uses data from the company for analysis and the results can be used as a basis for insurance companies in making decisions, especially those related to further insurance marketing to customers who have participated in insurance or who are still actively registered in payment insurance. Fuzzy C-Means can be used for clustering the customer datasets. It obtained 3 clustering results using Partition Coefficient (PC) in determining the validity index and the centers value was ranged from 0.5 to 1.0.
Retrospective Analysis of Community-acquired Pneumonia in Young Children from Large Families
Authors: Aliyeva Zh.
Published: April 2021

The study of the clinical course of community-acquired pneumonia in young children from large families was conducted. The study was retrospective. Children suffered from community-acquired pneumonia of moderate and severe severity. Revealed that community-acquired pneumonia often suffers from young children, mostly boys.
Comprehensive Treatment Plan for Idiopathic Neurovasculitis
Authors: Usenko V. , Umetalieva M.
Published: April 2021

Goal is to develop a comprehensive treatment plan for patients with idiopathic retinovasculitis, taking into account etiopathogenetic and clinical data from the retina. 86 patients (172 eyes) with retinal angiitis of idiopathic genesis were examined and were subject to treatment. The average age of the patients was 22.0 ± 0.17. Clinical forms of retinal changes: angioretinopathy — 16 eyes, 8 patients — 9.3%; neuroretinopathies — 104 eyes, 52 patients — 60.5%; neurovasculitis — 24 eyes, 12 patients — 14%; retinal angiopathy — 28 eyes, 14 patients — 16.2%. According to the severity of fundus changes: mild — 33 patients (66 eyes) — 38.4%; average — 30 patients (60 eyes) — 34.9%; severe — 23 patients (46 eyes) — 26.7%. The special methods of examining patients included: autoperimetry, eye biomicroscopy, direct and reverse ophthalmoscopy, OST of the optic nerve disc and macula, autofluorescent OCT of the retinal vessels, and optic disc with calibrometry, ultrasound dopplerography of the retinal vessels. The main principles of the therapy: 1. Suppression of immune inflammation in the acute phase and in the relapsing phase (treatment with HA, the appointment of immunosuppressants and immunostimulants in a prolonged course). 2. Correction of hemostasis and hemocirculatory disorders in the vessels of the retina. 3. Drug, symptomatic therapy and surgical treatment. Discussion of treatment results: Significant increase in visual acuity: in angioretinopathy from 0.45±0.24 to 0.9±0.14 (P <0.01); with neuroretinopathies from 0.34±0.2 to 0.85±015 (P <0.01); with concomitant maculopathy from 0.44±0.2 to 0.7±0.23 (P <0.01) and macular degeneration from 0.02±0.063 to 0.3±0.24 (P <0.05). There was an increase in visual acuity after treatment with a severe degree from 0.02±0.054 to 0.3±0.24 (P<0.05), with an average - from 0.5±0.24 to 0.9±0.13 (P<0.01), with mild — from 0.7±0.23 to 1.0±0.10. A significant decrease in the frequency of retinal changes after treatment was revealed: angioretinopathies up to 3.5% versus 9.3%; neuroretinopathies up to 11.6% versus 60.5%; maculopathy up to 8.7% versus 26.2%. The effectiveness of the treatment is due to the normalization of indicators of the immune status and hemocirculatory disorders in the retinal vessels according to calibrometry data. Thus: Complex treatment aimed at the main pathogenetic links in the development of idiopathic retinovasculitis contributes to the relief of pathological processes, reduction of complications, and eye disability.
Automation of the Process of Measuring and Evaluating Intermittent Industrial Noise
Authors: Balakina N. , Balakin A.
Published: April 2021

The estimation of intermittent industrial noise is considered, and one of the options for optimizing and automating the process of measuring industrial noise is proposed. A generalized block diagram of a noise dosimeter and a scheme of a measuring complex for dose estimation of noise using several microphones are presented.
Analysis of Cottonseed Separation Process on a Unified Working Machine
Authors: Mamadjanov B. , Shukuraliev A.
Published: April 2021

Numerous studies have proved the high efficiency of using electric methods for separating seeds of agricultural crops during their cleaning and separation, when studying the different quality of seeds and pre-sowing treatment. The article presents the results of research on the separation of seeds on a cylindrical working organ. A mathematical model of the seed separation process is presented.
ANALYSIS OF PTKIN OPPORTUNITIES: QUALITY MEASUREMENT THROUGH THE MALCOLM BALDRIGE CRITERIA FOR USING THE WORLD CLASS UNIVERSTY
Authors: Fauzi Ihwan
Published: April 2021

This study analyzes the opportunity for PTKIN to reach World Class University using criteria, especially at UIN Sunan Kalijaga Yogyakarta. The quality of an educational institution needs to be continuously improved (continuous improvement) to increase competitiveness. The research used a qualitative approach to the type of case study. Data collection techniques were carried out through; observation, interview and documentation. Furthermore, the research data is presented in a descriptive narrative form. The results of the study show that the accreditation is A (the highest score), but if it is measured or assessed by international standards EdPEx may only get a score in the interval 476 - 575, so that internationally it is categorized as a Good Performance University, yet it has NOT reached the World Class University. Improved by using a new standard to reach a world class university, Malcolm Baldrige is an international standard quality audit that is ready to fight the changing times. Malcolm Baldrige developed a flexible and creative approach in line with the needs of organization, especially the State Islamic Religious College.
The Medieval Urbanism of Ghazni (Afghanistan, 10th–12th Centuries). A Cross-Reading of Textual and Material Evidence
Authors: Allegranzi Viola
Published: April 2021

Attempts to reconstruct the historical geography of medieval Ghazni are complicated by the scarceness and discontinuity of both textual and material sources. This calls for a cross-check of archaeological and epigraphic data with the testimony of medieval geographers, chroniclers and poets who were conversant with the former capital city of the Ghaznavid sultanate. Such an investigation provides new insights into the growth principles of the town. The close interrelation between secular and religious spaces emerges as one of the main features of Ghaznavid state-sponsored monuments, and may have had an influence on the further developments of the urban fabric.
Будівельні споруди південної частини «цитаделі» городища Дикий Сад
Authors: Horbenko Kyrylo
Published: April 2021

Розкрито конструктивні особливості будівельних споруд № 24 та 24-а городища Дикий Сад, що розташовувалися у південній частині «цитаделі». Охарактеризовані структура та принципи будови, а також особливості внутрішнього заповнення ям. Проаналізовано матеріальні предмети (керамічний посуд, вироби з кістки, рогу, глини, каменю, бронзи), що зафіксовані у культурному шарі споруд.

Встановлено, що приміщення № 24 можна віднести до житлових (наземних) споруд з набором стовпових, господарських і господарсько-ритуальних ям. Приміщення 24-а, виходячи з конструктивних особливостей, характеру та заповнення ям, а також зафіксованих артефактів, можна віднести до наземних споруд господарсько-ритуального призначення, де навколо центрального вогнища розташовувалися багатофункціональні ями (стовпові, господарські, господарсько-ритуальні). Однак, можливо, що об’єкт використовувався як житлова споруда, при чому в певний час, або на початку виникнення життя на городищі, або наприкінці його існування.

Усі артефакти, що зафіксовано в основному заповненні й у заповненні ям приміщення № 24 та 24-а, є характерними для колекції матеріальних предметів Дикого Саду та відносяться до старожитностей білозерсько-тудоровського часу регіону Північно-Західного Причорномор’я.
Зольник № 2 античного святилища Вікторівка-І: загальна характеристика
Authors: Bondarenko Denys , Smyrnov Oleksandr
Published: April 2021

У статті подається опис конструктивних особливостей зольника № 2, який входить до системи культових споруд античного святилища Вікторівка-І. Розглядаються планіграфія та стратиграфія об’єкту, описується структура котловану. Подано короткі кількісно-якісні статистичні дані щодо решток матеріальної культури, зафіксованих при розкопках зольнику. Наведений аналіз культурних решток дозволяє віднести досліджений об’єкт до ранньоелліністичного часу й інтерпретувати як жертовник прикордонного святилища Ольвійського поліса.
Уособлення річкових богів у монетному карбуванні римської провінції Азія
Authors: Baukova Anastasia
Published: April 2021

Чудовим джерелом до вивчення різних аспектів історії та культури античності є монети. У статті аналізуються персоніфікації річкових богів-уособлень головних річок заходу Малої Азії. Вони були транспортними артеріями, джерелом постачання питної води та продуктів харчування, природними кордонами між областями Малої Азії.

Монетне карбування із персоніфікаціями дає змогу відтворити гідрографічну ситуацію у регіоні, адже на теперішній час частина водних артерій змінила своє русло чи взагалі зникла. Також піднято питання про потребу перегляду певних трактувань символів. Встановлено, що у провінції доволі швидко сформувався уніфікований спосіб персоніфікації річкових богів, але особливого поширення у монетному карбуванні міст провінції припав на другу половину ІІ – першу половину ІІІ ст. н.е. Аналіз легенд дозволяє також виділити певні епітети та локальні особливості загальногрецьких божеств.
SH2B3, Transcribed by STAT1, Promotes Glioblastoma Progression Through Transducing IL-6/gp130 Signaling to Activate STAT3 Signaling
Authors: Cai Shan , Lu Jian-xiang , Wang Yan-pei , Shi Chao-jia , Yuan Tian , Wang Xiang-peng
Published: April 2021

Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The aberrant activation of STAT3 commonly occurs in GBM and is a key player in GBM tumorigenesis. Yet, the aberrant activation of STAT3 signaling is not fully understood. Here, we report that SH2B adaptor protein 3 (SH2B3) is highly expressed in GBM and preferentially expressed in GBM stem cells (GSCs). Moreover, SH2B3 high expression predicts worse survival of GBM patients. Targeting SH2B3 considerably impairs GBM cell proliferation, migration, and GSCs’ self-renewalin vitroas well as xenograft tumors growthin vivo. Additionally, we provide evidence suggesting that STAT1 directly binds to the promoter of SH2B3 and activates SH2B3 expression in the transcriptional level. Functionally, SH2B3 facilitates GBM progressionviaphysically interacting with gp130 and acting as an adaptor protein to transduce IL-6/gp130/STAT3 signaling. Together, our work firstly uncovers that the STAT1/SH2B3/gp130/STAT3 signaling axis plays critical roles in promoting GBM progression and provides insight into new prognosis marker and therapeutic target in GBM.
Targeting Solid Tumors With BTK Inhibitors
Authors: Uckun Fatih M. , Venkatachalam Taracad
Published: April 2021

The repurposing of FDA-approved Bruton’s tyrosine kinase (BTK) inhibitors as therapeutic agents for solid tumors may offer renewed hope for chemotherapy-resistant cancer patients. Here we review the emerging evidence regarding the clinical potential of BTK inhibitors in solid tumor therapy. The use of BTK inhibitors may through lead optimization and translational research lead to the development of new and effective combination regimens for metastatic and/or therapy-refractory solid tumor patients.
Heterozygous Recurrent Mutations Inducing Dysfunction of ROR2 Gene in Patients With Short Stature
Authors: Gui Baoheng , Yu Chenxi , Li Xiaoxin , Zhao Sen , Zhao Hengqiang , Yan Zihui , Cheng Xi , Lin Jiachen , Zheng Haiyang , Shao Jiashen , Zhao Zhengye , Zhao Lina , Niu Yuchen , Zhao Zhi , Wang Huizi , Xie Bobo , Wei Xianda , Gui Chunrong , Li Chuan , Chen Shaoke , Wang Yi , Song Yanning , Gong Chunxiu , Zhang Terry Jianguo
Published: April 2021

Purpose

ROR2, a member of the ROR family, is essential for skeletal development as a receptor of Wnt5a. The present study aims to investigate the mutational spectrum of ROR2 in children with short stature and to identify the underlying molecular mechanisms.

Methods

We retrospectively analyzed clinical phenotype and whole-exome sequencing (WES) data of 426 patients with short stature through mutation screening of ROR2. We subsequently examined the changes in protein expression and subcellular location in ROR2 caused by the mutations. The mRNA expression of downstream signaling molecules of the Wnt5a–ROR2 pathway was also examined.

Results

We identified 12 mutations in ROR2 in 21 patients, including 10 missense, one nonsense, and one frameshift. Among all missense variants, four recurrent missense variants [c.1675G > A(p.Gly559Ser), c.2212C > T(p.Arg738Cys), c.1930G > A(p.Asp644Asn), c.2117G > A(p.Arg706Gln)] were analyzed by experiments in vitro. The c.1675G > A mutation significantly altered the expression and the cellular localization of the ROR2 protein. The c.1675G > A mutation also caused a significantly decreased expression of c-Jun. In contrast, other missense variants did not confer any disruptive effect on the biological functions of ROR2.

Conclusion

We expanded the mutational spectrum of ROR2 in patients with short stature. Functional experiments potentially revealed a novel molecular mechanism that the c.1675G > A mutation in ROR2 might affect the expression of downstream Wnt5a–ROR2 pathway gene by disturbing the subcellular localization and expression of the protein.
The Potential of Induced Pluripotent Stem Cells to Test Gene Therapy Approaches for Neuromuscular and Motor Neuron Disorders
Authors: Cappella Marisa , Elouej Sahar , Biferi Maria Grazia
Published: April 2021

The reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) represents a major advance for the development of human disease models. The emerging of this technique fostered the concept of “disease in a dish,” which consists into the generation of patient-specific modelsin vitro. Currently, iPSCs are used to study pathological molecular mechanisms caused by genetic mutations and they are considered a reliable model for high-throughput drug screenings. Importantly, precision-medicine approaches to treat monogenic disorders exploit iPSCs potential for the selection and validation of lead candidates. For example, antisense oligonucleotides (ASOs) were tested with promising results in myoblasts or motor neurons differentiated from iPSCs of patients affected by either Duchenne muscular dystrophy or Amyotrophic lateral sclerosis. However, the use of iPSCs needs additional optimization to ensure translational success of the innovative strategies based on gene delivery through adeno associated viral vectors (AAV) for these diseases. Indeed, to establish an efficient transduction of iPSCs with AAV, several aspects should be optimized, including viral vector serotype, viral concentration and timing of transduction. This review will outline the use of iPSCs as a model for the development and testing of gene therapies for neuromuscular and motor neuron disorders. It will then discuss the advantages for the use of this versatile tool for gene therapy, along with the challenges associated with the viral vector transduction of iPSCs.
New Quinolinone O-GlcNAc Transferase Inhibitors Based on Fragment Growth
Authors: Weiss Matjaž , Loi Elena M. , Sterle Maša , Balsollier Cyril , Tomašič Tihomir , Pieters Roland J. , Gobec Martina , Anderluh Marko
Published: April 2021

O-GlcNAcylation is an important post-translational and metabolic process in cells that must be carefully regulated. O-GlcNAc transferase (OGT) is ubiquitously present in cells and is the only enzyme that catalyzes the transfer of O-GlcNAc to proteins. OGT is a promising target in various pathologies such as cancer, immune system diseases, or nervous impairment. In our previous work we identified the 2-oxo-1,2-dihydroquinoline-4-carboxamide derivatives as promising compounds by a fragment-based drug design approach. Herein, we report the extension of this first series with several new fragments. As the most potent fragment, we identified 3b with an IC50 value of 116.0 μM. If compared with the most potent inhibitor of the first series, F20 (IC50 = 117.6 μM), we can conclude that the new fragments did not improve OGT inhibition remarkably. Therefore, F20 was used as the basis for the design of a series of compounds with the elongation toward the O-GlcNAc binding pocket as the free carboxylate allows easy conjugation. Compound 6b with an IC50 value of 144.5 μM showed the most potent OGT inhibition among the elongated compounds, but it loses inhibition potency when compared to the UDP mimetic F20. We therefore assume that the binding of the compounds in the O-GlcNAc binding pocket is likely not crucial for OGT inhibition. Furthermore, evaluation of the compounds with two different assays revealed that some inhibitors most likely interfere with the commercially available UDP-Glo™ glycosyltransferase assay, leading to false positive results. This observation calls for caution, when evaluating UDP mimetic as OGT inhibitors with the UDP-Glo™ glycosyltransferase assay, as misinterpretations can occur.