bluuebunny/crossref_metadata_2025 huggingface dataset:
Green synthesis of zinc oxide nanoparticles with bioactive compounds of Actinomycete, Amyculatopsis roodepoortensis strain EA7 and its effect on cell line HT-29
Authors: Amiri Elham , Mirpour Mirsasan , Issazadeh Khosro , Rasti Behnam
Published: June 2024

The present study describes the biosynthesis of zinc oxide nanoparticles using the extract from the actinomycete isolate Amycolatopsis roodepoortensis strain EA7. The 16S rRNA gene analysis revealed that strain EA7 belonged to the Amycolatopsis roodepoortensis species with 99.63% confidence. Their physical characteristics were examined using XRD, FTIR, SEM, TEM, DLS, Zeta potational, and EDX. Microscopic examination revealed spherical ZnO NPs with an estimated average size of 2.98 ± 0.69 nm. The antibacterial and anticancer effect (colon cancer cell line HT-29) of these nanoparticles was observed in a dose-dependent manner. The values of IC50 ZnO-NPs for cell line HT-29 was calculated as 47 µg/ml. Also, the expression level of ATM, ATR, CHK1 and CHK2 genes effective in apoptosis as compared with the control sample in the cell line HT29 was increased as 2.35 ± 0.293, 2.87 ± 0/280, 3.67 ± 0.378, and 5.86 ± 0.495, respectively(P < 0.0001), which indicates the induction Apoptosis in HT-29 cells. However, there was no significant differences in reducing the expression of MMP-9 and BCL-2 genes effective in carcinogenesis as compared with the control sample. Also, flowcytometry results showed, 46.74% of the cells HT-29 entered the apoptosis stage (P < 0.0001). In the analysis of the cell cycle in the Sub-G1 phase, the percentage of cell population increased (35.60%), which indicates the induction of apoptosis (P < 0.001). Given the high antimicrobial and anticancer potential of the synthesized nanoparticles, this research represents a significant step towards further studies on these nanoparticles and the development of a new generation of antimicrobial and anticancer agents.
The Relationship Between CRP Levels and Dental Caries in the US Adult Population: Evidence from NHANES 2015-2018
Authors: AlShammari Abdullah , AlSaleh Saleh , AlKandari Abdulaziz , AlSaqabi Sara , AlJalahmah Dalal , AlSulimmani Woroud , AlDosari Muath , AlHazmi Hesham , AlQaderi Hend
Published: June 2024

Background:
Dental caries remains one of the most prevalent diseases worldwide, affecting 36% of the global population. Despite numerous efforts to diagnose, predict, and prevent this condition, the incidence continues to rise. Considering the emerging connection between oral and systemic health, it is worth exploring the various factors associated with this widespread disease. Notably, the level of C-reactive protein (CRP), a marker of inflammation, has been identified as a risk factor for several health conditions, including periodontal disease. This study investigates the association between CRP levels and dental caries within the United States, utilizing data from the National Health and Nutrition Examination Survey (NHANES).
Methods
The study analyzed data from the 2015–2018 NHANES cycles, focusing on a nationally representative sample of individuals aged 30–65 years. Weighted multivariable Poisson and logistic regression analyses were employed to explore the relationship between dental caries and CRP levels, adjusting for age, gender, race, education level, diabetes status, and gum disease.
Results
Our analysis revealed a statistically significant positive association between CRP levels and dental caries. Specifically, 40.4% of participants with dental caries exhibited elevated CRP levels. The age group of 45–64 years displayed the highest prevalence of increased CRP levels (34.8%). Regression analyses further substantiated the association, with the Poisson regression indicating a 60% increase in the Adjusted Mean Ratio (AMR) of dental caries for higher CRP levels (AMR: 1.6, p-value: <0.01) and the logistic regression analysis showed that individuals with higher CRP levels have a 50% increase in the odds of developing dental caries (AOR: 1.5, p-value: <0.01).
Conclusion
The results of this cross-sectional study of the U.S. population highlight the positive association between increased CRP levels and the prevalence of dental caries. These findings contribute to the growing body of evidence supporting the integration of oral and systemic health care. Further research is necessary to deepen our understanding of the mechanistic relationship between CRP levels and dental caries.
The Impact of Yangtze River Delta Regional Integration on the Scientific and Technological Achievements Transformation in Higher Education: A Dynamic QCA Analysis Based on Provincial Panel Data
Authors: Yuxin Zhang
Published: June 2024

Economic, policy, and resource factors within the regional integration of the Yangtze River Delta are crucial pathways for promoting the transformation of scientific and technological achievements in higher education. This study examines the multifactorial synergistic effects behind the differences in scientific and technological achievements transformation in the Yangtze River Delta from the space-time dimension, offering important insights for practical applications. Drawing on interface theory, this study constructs an analytical framework of economic integration-policy integration-innovation resource integration and employs dynamic QCA to analyze provincial panel data from 2013 to 2022. The study explores the configurational effects of economic integration, policy integration, and innovation resource integration on the transformation levels of scientific and technological achievements in the Yangtze River Delta. By combining between-group and within-group analyses, the study investigates the spatial distribution differences in provincial coverage. The findings reveal that no univariate factor is necessary for high levels of scientific and technological achievement transformation. Three distinct pathways were identified in this study, which are the regional economic development-innovation resource integration model, economic integration-research collaboration model, and regional economic development-innovation resource integration model. In the temporal dimension, apart from a collective decline in pathway consistency in 2016 due to economic structural adjustments and reforms in research and development (R&D) funding management, there were fluctuations in consistency from 2019 to 2022, likely driven by COVID-19. In the spatial dimension, two configurations showed significant regional differences in provincial coverage distribution.
Sex Differences in Physical Activity of US children at age 13 months: Child and Mother Physical Activity Study (CAMPAS)
Authors: Kwon Soyang , Welch Sarah , Capan Selin
Published: June 2024

Background
Lower physical activity (PA) has been observed in females compared to males among preschool-aged and older children. However, the timing of when the sex gap emerges is unclear. The purpose of this study was to investigate whether females have lower PA levels than males in the early toddler age and to explore whether gross motor competency and PA parenting practices might explain a sex difference in PA.
Methods
The study design was cross-sectional. Participants were a community-based sample of 137 children aged 10–16 months residing in US Midwest urban/suburban area. Participants’ mothers completed a survey that contained a demographic questionnaire, the Ages and Stages Questionnaire gross motor competency subscale, and a PA parenting practices questionnaire. Participating children wore an ActiGraph accelerometer on their hip for 7 days. Accelerometer-measured time spent in moderate- and vigorous intensity PA (MVPA; minutes/day) and in total PA (minutes/day) were calculated. Multivariable linear regression analysis was conducted to predict MVPA and total PA by sex, gross motor competency, PA parenting practices, and socioeconomic status.
Results
Among 137 participants (54.0% female), average age was 13.6 months (SD = 1.7). MVPA was 72 ± 25 and 79 ± 26 minutes/day for females and males, respectively (p = 0.14). Total PA was 221 ± 48 and 238 ± 47 minutes/day for females and males, respectively (p = 0.04). Both gross motor competency and PA-encouraging parenting practices were positively associated MVPA (p = 0.01 and p = 0.02, respectively) and total PA (p = 0.02 and p = 0.01, respectively); however, these relationships did not differ by sex (p = 0.11 and p = 0.89, respectively). After accounting for gross motor competency and PA parenting practices, total PA was 15 minutes/day lower among females than males (p = 0.04).
Conclusions
This cross-sectional study of US children observed a sex gap in total PA at 10–16 months of age. Gross motor development and PA parenting practices did not differ by child sex nor explain the sex difference in PA. A longitudinal investigation should follow to further narrow down when sex differences in PA emerge and to determine the factors that lead to this difference.
Arctica islandica (Bivalvia) selective feeding on natural plankton in the White Sea
Authors: Lavrentyev Peter , Lezin Peter
Published: June 2024

The ocean quahog Arctica islandica (L.) has been the focus of extensive research due to its commercial value and extreme longevity. However, little is known about its natural trophic behavior. In a feeding experiment that used plankton and clams collected from the White Sea coast, Arctica cleared a wide spectrum of particles, ranging from picoplanktonic cyanobacteria and nano-cryptophytes to diatom chains. Diatoms and heterotrophic dinoflagellates formed the bulk of Arctica ration, which equaled ~ 1% of its tissue carbon per day. The estimated prey selectivity increased with particle size, but the clams also discriminated between prey of similar size and taxonomy. The measured Arctica mass-specific filtration rates corresponded to those published earlier for intertidal mussels. Implications for Arctica growth are discussed.
Intrauterine transmission, pregnant outcomes after infection of SARS-CoV-2 during first or second trimester: a small cohort study during Omicron stage
Authors: Zhu Xiangyu , Jiang Zihan , Cao Peixuan , Wei Hongxia , Jiang Peipei , Yang Ying , Zhou ChunXiang , Hu Xiaohan , Wu Xing , Liu Wei , Gu Leilei , Zhou Wensan , Xu Hongpan , Li Jie
Published: June 2024

Background
The emergence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has posed significant public health challenges. Although vaccination provides protection against severe COVID-19, its efficacy against infection and mild symptoms wanes, leaving pregnant women, who are at an increased risk of severe complications, vulnerable.
Methods
In a prospective study conducted from January 31 to February 28, 2023, 225 women with 239 fetuses underwent chromosomal microarray analysis via amniocentesis. Participants were tested for SARS-CoV-2 RNA to ensure negativity prior to the procedure. Maternal and infection-related data were collected, and amniotic fluid samples were analyzed for SARS-CoV-2 RNA using qRT-PCR. Pregnancy outcomes were assessed through obstetric ultrasound and follow-ups.
Results
None of the 140 amniotic fluid samples tested positive for SARS-CoV-2 RNA, indicating no intrauterine transmission. There were no significant differences in the rates of premature delivery or birth weight between the groups infected in the first and second trimesters.
Conclusion
The study found no evidence of vertical transmission or adverse pregnancy outcomes following SARS-CoV-2 infection during the first and second trimesters. The impact of Omicron variant infection during these periods was mild, suggesting that amniocentesis beyond the acute stage of COVID-19 is safe.
Sand fly blood meal volumes and their relation to female body weight
Authors: Volfová Věra , Jančářová Magda , Volf Petr
Published: June 2024

Background
Sand fly females took a blood meal to develop eggs. The size of the blood meal is important for the fecundity but also affects the dose of pathogens acquired by females while feeding on infected host or during experimental membrane-feeding experiments.
Methods
Under standard laboratory conditions we compared blood meal volumes taken by females of ten sand fly species belonging to four genera: Phlebotomus, Lutzomyia, Migonomyia and Sergentomyia. Amount of ingested blood was determined by haemoglobin assay. In addition, we weighted unfed sand flies to calculate a ratio between body weight and blood meal weight.
Results
The mean blood meal volume ingested by sand fly females of different species ranged from 0.47 to 1.01 µl. Five species studied, Phlebotomus papatasi, P. duboscqi, Lutzomyia longipalpis, Sergentomyia minuta and S. schwetzi took about double size blood meal in comparison to Migonomyia migonei. In females, the mean body weight ranged from 0.183 mg in S. minuta to 0.369 mg in P. duboscqi. In males, the mean body weight ranged from 0.106 mg in M. migonei to 0.242 mg in P. duboscqi. Males were always lighter than females, the ratio between sexes ranged from 75% in P. argentipes to 52% in P. tobbi.
Conclusions
Interspecific analysis did not reveal any correlation between mean blood meal volume/weight and the mean weight of females (Mbl/Mf). Most species took a blood meal 2.25–3.05 times higher their body weight. Relatively tiny females of P. argentipes took 3.34 times their body weight. The highest (Mbl/Mf) ratio was found in both Sergentomyia species studied; females of S. minuta and S. schwetzi took bloodmeals 4,5–5 times higher than their body weight. This parameter is substantially higher then reported for any mosquitoes and biting midges.
Quality of Bioplastic Made From Tofu Waste Starch With Variations of Glycerol Using the Melt Intercalation Method
Authors: Rijal Muhammad , Surati Surati , Natsir Nur Alim , Irmawanty Irmawanty , Tomia Ratni , Pary Corneli , Samputri Salma
Published: June 2024

Bioplastics are plastics made from natural (organic) materials and are renewable and easily degraded by nature. This type of research is quantitative research with a laboratory experimental approach with variations in glycerol volume (ml) as the independent variable and bioplastic quality as the dependent variable. The results showed that there were color gradations in each treatment and variations in glycerol volume had an effect on thickness, tensile strength, elongation, elastic modulus, water absorption and bioplastic degradation. Bioplastics made from starch waste starch for each treatment meets JIS-2-1707, ASTM-D-6002 and SNI 7818:2014 standards on parameters of thickness, tensile strength and degradability
Exploring a new clean technology in renewable energy production: The system design of Aloe vera-based plant microbial fuel cells
Authors: Çek Nurettin , Tuna Aysun , Çelik Ali , Orhan Ayhan , Sezer Selman
Published: June 2024

Plant-based plant microbial fuel cells are introduced as devices that directly convert solar energy into electrical energy through photosynthesis reactions. Plant microbial fuel cells, which are a renewable and sustainable energy source, produce bioelectricity at different levels depending on plant species and characteristics. In this paper, a plant microbial fuel cell was manufactured by planting Aloe vera in natural plant soil and placing graphite electrodes, then it was operated by giving pure water. Thus, an Aloe vera based plant-microbial fuel cell was manufactured and open circuit potential, linear scanning voltammetry and electrochemical impedance spectroscopy tests were performed. The peak open-circuit potential generated by the aloe vera-based plant microbial fuel cell was 288 mV, and the peak value of power density reached levels of 200 W/m2. The high activation resistance and ohmic resistance of aloe vera-based plant microbial fuel cell triggered total internal resistance, causing it to show internal resistance at levels of 10 kiloohms. The aloe vera-based system demonstrates promising potential for electricity generation, as evidenced by its peak open-circuit potential. However, the high activation resistance and ohmic resistance leading to a total internal resistance of 10 kiloohms highlight areas for improvement to enhance its efficiency and practicality for widespread use. Further research and development are needed to address these challenges and unlock the full capabilities of aloe vera-based P-MFCs.
Response of carbon storage to land use change and Multi-Scenario predictions in Zunyi, China
Authors: Liu Yi , Mei Xuemeng , Yue Li , Zhang Mingming
Published: June 2024

Evaluating and predicting how carbon storage (CS) responds to land use change can optimize future spatial layouts and coordinate the relationship between land use and ecosystem services. This study aimed to explore the spatiotemporal evolution of CS in Zunyi from 2000 to 2020, investigate the driving factors of CS, and predict spatiotemporal changes under multiple scenarios in 2030. Woodland (> 62%) and farmland (> 30%) are the main land use types in Zunyi. The land use changes included decreases in farmland (-0.92%) and grassland (-0.76%) and an increase in construction land (+ 0.92%). In 2000, 2010, and 2020, CS in Zunyi was 658.77×10^6 t, 661.44×10^6 t, and 658.35×10^6 t, respectively, initially increasing then decreasing. Woodland, farmland and grassland conversions to construction land and water were primarily responsible for CS loss. The NDVI is the main driving factor influencing the spatial pattern of CS (q > 10%). Furthermore, the impacts of the human footprint index and population density are increasing. In 2030, the CS in Zunyi is projected to decrease under the NDS, ECS and CDS scenarios. Under the ECS, CS is estimated to be 656.67×10^6 t, with the smallest decrease (-0.26%); moreover, this scenario effectively alleviates the decreases in farmland and woodland.
Dihydroartemisinin inhibits the susceptibility of Anopheles stephensi to Plasmodium by activating Toll signaling pathway
Authors: Liu Tingting , Zheng Dan , Wang Jing , Li Xin , Yu Shasha , Liu Zhilong , Zheng Feifei , Zhao Caizhi , Yang Xuesen , Wang Ying
Published: June 2024

Background
Malaria is a serious public health concern. Artemisinin and its derivatives are first-line drugs for the treatment of Plasmodium falciparum malaria. In mammals, artemisinin exhibits potent anti-inflammatory and immunoregulatory properties. However, it is unclear whether artemisinin plays a regulatory role in the innate immunity of mosquitoes, thereby affecting the development of Plasmodium in Anopheles when Artemisinin and its metabolites enter mosquitoes. This study aimed to determine the effect of DHA, a first-generation semisynthetic derivative of artemisinin, on innate immunity and malaria vector competence of Anopheles stephensi.
Methods
Anopheles stephensi was fed Plasmodium-infected mice treated with dihydroartemisinin (DHA) via gavage, Plasmodium-infected blood containing DHA in vitro, or DHA-containing sugar, followed by Plasmodium yoelii infection. The engorged female mosquitoes were separated and dissected 8 days after infection. Plasmodium oocysts were counted and compared between the control and DHA-treated groups. Additionally, total RNA and proteins were extracted from engorged mosquitoes 24 and 72 h post-infection (hpi). Real-time PCR and western blotting were performed to detect the transcriptional levels and protein expression of immune molecules in mosquitoes. Finally, the Toll signaling pathway was inhibited via RNAi and the infection intensity was analyzed to confirm the role of the Toll signaling pathway in the effect of DHA on the vector competence of mosquitoes.
Results
DHA treatment via different approaches significantly reduced the number of Plasmodium oocysts in mosquitoes. The transcriptional levels of anti-Plasmodium immune genes, including TEP1, LRIM1, and APL1C; Toll pathway genes, including Tube, MyD88, and Rel1; and the effector Defensin 1, were upregulated by DHA treatment at 24 and 72 hpi. TEP1 and Rel1 protein expression was significantly induced under DHA treatment. However, Rel1 knockdown in DHA-treated mosquitoes abrogated DHA-mediated refractoriness to Plasmodium infection.
Conclusions
DHA treatment effectively inhibited the development of P. yoelii in An. stephensi by upregulating mosquitoes’ Toll signaling pathway, thereby influencing the susceptibility of Anopheles to Plasmodium.
TiO 2 sol-gel thin films: role of acidic and basic pH on physical characteristics
Authors: Khima Nassima , Chelouche Azeddine , Challali Fatiha , Djouadi Djamel , djermoune Athmane , bellucci Stefano , Touam Tahar
Published: June 2024

In this work, we discuss the effects of acidic and basic pH on the structural, morphological, and optical properties of TiO2 sol-gel thin films deposited on glass substrates by the dip coating method. X-ray diffraction (XRD) and Raman spectroscopy (RS) show that all the samples are polycrystalline and possess anatase structure with preference orientation along the (101) direction. It is found that crystallite size decreases with the increasing pH of the sol for both acidic and basic pH. Atomic force microscopy (AFM) demonstrated a homogenous grain distribution and smooth surface of all films. The surface roughness is influenced by the pH of the sol. UV-visible spectroscopy revealed a higher level of transparency for all films. The deposition medium's pH significantly influences the thin films' optical properties, particularly the direct and indirect band gaps, and refractive index. Photoluminescence measurements revealed a strong violet-blue emission band whose intensity depends strongly on the pH of the sol. Particularly, the emission intensity from the film deposited at a pH value of 10 is significantly lower and exhibited a distinct spectral signature compared to the other samples.
Synthetic protein degradation circuits using programmable cleavage and ligation by Sortase A
Authors: Chen Wilfred , Yang Hopen
Published: June 2024

BioPROTACs are heterobifunctional proteins designed for targeted protein degradation (TPD). They are useful not only for probing protein functions but also offer a therapeutic avenue for modulating disease-related proteins. To extend the use of TPD beyond just protein attenuation, we introduce a synthetic framework for logic-gated, switchable TPD to achieve temporal control of protein content. By exploiting both the cleavage and ligation functionalities of Sortase A (SrtA), we present a new strategy utilizing SrtA as the control input to direct bioPROTAC activity for switchable TPD. Furthermore, by layering the SrtA input with protease gating, new conditional degradation phenotypes can be readily adapted with minimal modifications to the design. This new Logic-gated AdPROM deploying SrtA-mediated Element Recombination (LASER) platform allows us to expand the possible protein degradation outcomes in mammalian cells using Boolean logic operationsdepending on the input combinations. The flexibility to temporally modulate the level of multiple native intracellular proteins can potentially lead to applications from therapy to diagnostics and biotechnology.
The People You Can Count on in the Italian Regions
Authors: Arnone Massimo , Leogrande Angelo
Published: June 2024

In the following article, we analyzed a variable present in the ISTAT-BES dataset, namely "People You Can Count On"-PYCC for the Italian regions. Following an analysis of the time series aimed at highlighting the trends of the regions, we created a clustering with a k-Means algorithm optimized with the Silhouette coefficient. The data shows the presence of two clusters. We then present an econometric model aimed at estimating the value of PYCC based on a set of socio-economic variables. The results are also discussed in light of the economic policy implications.
JEL Classification: D6, D64, D9, J21, D63
NMDA and GABA Receptor-Mediated Plasticity Induced by 10-Hz Repetitive Transcranial Magnetic Stimulation
Authors: Kweon Jamie , Vigne Megan , Fukuda Andrew M. , Ren Boyu , Carpenter Linda L. , Brown Joshua C.
Published: June 2024

Although 10-Hz repetitive transcranial magnetic stimulation (rTMS) is an FDA-approved treatment for depression, we have yet to fully understand the mechanism through which rTMS induces therapeutic and durable changes in the brain. Two competing theories have emerged suggesting that 10-Hz rTMS induces N-methyl-D-aspartate receptor (NMDAR)-dependent long-term potentiation (LTP), or alternatively, removal of inhibitory gamma-aminobutyric acid receptors (GABARs). We examined these two proposed mechanisms of action in the human motor cortex in a double-blind, randomized, four-arm crossover study in healthy subjects. We tested motor-evoked potentials (MEPs) before and after 10-Hz rTMS in the presence of four drugs separated by 1-week each: placebo, NMDAR partial agonist d-cycloserine (DCS 100mg), DCS 100mg + NMDAR partial antagonist dextromethorphan (DMO 150mg; designed to “knock down” DCS-mediated facilitation), and GABAR agonist lorazepam (LZP 2.5mg). NMDAR agonism by DCS enhanced rTMS-induced cortical excitability more than placebo. This enhancement was blocked by combining DCS with NMDAR antagonist, DMO. If GABARs are removed by rTMS, GABAR agonism via LZP should lack its inhibitory effect yielding higher post/pre MEPs. However, MEPs were reduced after rTMS indicating stability of GABAR numbers. These data suggest that 10-Hz rTMS facilitation in the healthy motor cortex may enact change in the brain through NMDAR-mediated LTP-like mechanisms rather than through GABAergic reduction.
A comparative study on the knowledge of medical students at Al-Sham University regarding the symptoms and treatment of anaphylactic shock
Authors: Alo Jamil , Kabbani Prof. Samar
Published: June 2024

Objective: To compare the knowledge of human medicine students at Al-Sham University regarding the symptoms and treatment of anaphylactic shock.
Methods and materials: A cross-sectional study, in which a structured questionnaire consisting of 46 questions was created that assessed students' knowledge of anaphylactic shock and its treatment. It was directed to medical students in all years at Al-Sham Private University. Subjects were asked to answer the questionnaire and voluntary participation was considered as informed consent.
Results: Among 208 students, the percentage of those who had good knowledge of the symptoms and management of anaphylaxis was 16.7%, the percentage of those who had moderate knowledge was 23.1%, and those who had weak knowledge was 70.2%. The average knowledge score was 25.35, with a standard deviation of 11.2. The percentage of knowledge was higher among fifth-year students. Sixth, those with good and moderate income, residing in the city, unmarried, and male participants.
Conclusion: Knowledge regarding the management and symptoms of anaphylaxis was inadequate in almost all medical students studied. Improving education and training for students is essential to improve the diagnosis and management of anaphylaxis.
Utrecht Work Engagement Scale (nine items version): Translation and validation in Greek
Authors: Moisoglou Ioannis , Katsiroumpa Aglaia , Gallos Parisis , Kolisiati Antigoni , Tsiachri Maria , Tsakalaki Anastasia , Galanis Petros
Published: June 2024

Background
Work engagement is a critical issue among workers since it refers to the effective connection between workers and organizations.
Aim
To translate and validate the “Utrecht Work Engagement Scale” (UWES) (nine items version) in Greek.
Methods
Study population included 114 nurses in Greece. We performed our study during April 2024. We employed the forward-backward method to translate and adapt the UWES in Greek language. We examined the construct validity of the UWES by performing confirmatory factor analysis. We examined the concurrent validity of the UWES using the “Quiet Quitting Scale” (QQS), the single item burnout measure, and the “Global Transformational Leadership” (GTL) scale. We examined the reliability of the UWES by calculating Cronbach’s alpha.
Results
The UWES showed very good psychometric properties. Our confirmatory factor analysis confirmed the three-factor structure of the UWES; vigor, dedication and absorption. Concurrent validity of the Greek version of the UWES was very good. We found statistically significant correlations between the UWES and QQS (r = -0.605, p < 0.001), and GTL (r = 0.494, p < 0.001). We found that the “Utrecht Work Engagement Scale” had very good reliability since intraclass correlation coefficients for the nine items were higher than 0.813 (p < 0.001 in all cases). Moreover, Cronbach’s coefficient alpha for the UWES was 0.924.
Conclusions
The Greek version of the “Utrecht Work Engagement Scale” is a reliable and valid tool to measure work engagement among workers.
Optimizing Causal Interventions in Hybrid Bayesian Networks
Authors: Vonk Maarten , Vermetten Diederick , de Nobel Jacob , Brand Sebastiaan , Malekovic Ninoslav , Bäck Thomas , Laarman Alfons , Kononova Anna V.
Published: June 2024

Causality is increasingly integrated into decision-making processes. Often, the goal is to optimize over causal interventions to achieve specific policy objectives. However, research into causal optimization has bifurcated into either the online optimization of interventions in causal models or the offline optimization of decision rules in causal influence diagrams. This paper introduces an approximate method for offline optimizing interventions in arbitrary hybrid Bayesian networks using observational data. The optimization problem is approached by compiling discretized Bayesian networks as binary decision diagrams, whereafter running interventional queries is very efficient. This efficiency is exploited by running heuristic optimization algorithms to optimize over the interventional queries. By running experiments on a variety of large hybrid Bayesian networks, we demonstrate the practical utility of our method and discuss policy relevance.
Alternative energy as a driver of transformation processes in the energy sector
Authors: Kholod Anna
Published: June 2024

Renewable energy is actively developing both on the global market and within individual regions and countries. Alternative energy sources, particularly solar and wind, guarantee a stable and safe energy supply. Such systems ensure a reliable supply of energy in everyday life and in extreme situations, such as natural disasters or breakdowns in the operation of the energy infrastructure. The transition to alternative energy sources generally contributes to creating a stable, ecologically clean and environmentally friendly energy system, which has many advantages for society. The article aims to study the prerequisites and dynamics of the development of alternative energy. The article found out that the use and introduction of alternative energy sources is an important factor for restoring the ecological balance during the decarbonization of the economy. As of the end of 2022, wind power plants, solar power plants, home solar power plants, and small hydroelectric power plants are gaining popularity. The leaders in the number of new facilities installed from renewable energy sources in Ukraine are the Mykolaiv, Odesa, Kherson, and Zaporizhia regions. The analysis carried out in the article proved that the most common alternative sources in Ukraine and Europe are solar panels, wind power plants and smart energy. The authors systematized the advantages of solar panels, which define them as sustainable and stable energy sources for the future. The work concludes that wind power plants have more limitations due to the nature of the conditions, but with the development of technology, they have become more and more efficient. In addition, a promising direction for developing the modern energy system is using smart energy, which includes artificial intelligence, data analytics, and a system for collecting energy resources. Modern smart energy allows you to provide energy planning effectively and to warn of power outages.
Key Factors and Personal Influences on Consumer Consideration in Online Potted Plant Purchases
Authors: Tung Pei-Cheng , Tu Hung-Ming
Published: June 2024

The COVID-19 pandemic increased online shopping, including for potted plants; however, research on plant-purchasing behaviors outside of physical stores is limited. This study examined key factors that influence online plant purchases. Initially, 47 factors related to online plant purchases were identified. Personal factors encompassed gender, age, educational level, monthly income, gardening education, online purchase frequency, and living environment. Age quota sampling was used and 400 valid questionnaires were collected. Six common factors and 21 items were identified: consumer assurance, plant care and safety, well-being, service quality, pricing and promotions, and size and habits. Well-being was the most influential for online plant purchases. Service quality, data security, after-sales service, and pricing strategies were also important, with plant care and safety as secondary factors. Compared with men, women emphasized well-being and plant care more. Environmental factors such as naturalness and building density affected purchasing decisions. This study highlights the need for tailored marketing strategies focusing on service quality and emotional benefits to meet diverse consumer needs and preferences.
Evaluating Sweetpotato Varieties and Accessions in Hawai‘i
Authors: Halpin-McCormick Anna , Lucas Stacy , Keach James , Kantar Michael B. , Motomura-Wages Sharon , Miyasaka Susan C.
Published: June 2024

Thirty sweetpotato (Ipomoea batatas var. batatas) genotypes were evaluated for yield, resistances to weevil or nematode pests, and consumer acceptance across three field trials planted at Pepe‘ekeo, Hawai‘i Island between 2017 to 2020. At harvest, storage roots were graded according to market standards, followed by scoring for damage by sweetpotato weevil (Cylas formicarius elegantulus), rough sweetpotato weevil (Blosyrus asellus), or nematodes; namely root-knot nematode (Meloidogyne spp.) or reniform nematode (Rotylenchus reniformis) in each market class. There were significant differences in marketable yields among accessions when data were analyzed statistically across all three field trials, as well as individually. ‘Regal’ (PI 566650) and ‘Sumor’ (PI 566657) were among the top three highest-yielding genotypes for Trials 1 and 2 (when no insecticides were applied to control weevils), and among the top six highest-yielding genotypes for the joint analysis across three trials. Significant differences among genotypes for combined sweetpotato weevil damage (incidence of sweetpotato weevil alone or incidence of both weevils together) were found in the joint analysis across three trials. ‘Regal’ was among the lowest seven genotypes for combined sweetpotato weevil damage, supporting earlier reports of its moderate resistance to this pest. In addition, two genotypes produced by the World Vegetable Center (Shanhua, Taiwan) (WT-320 and WT-108), were among the lowest genotypes for combined sweetpotato weevil damage, in agreement with earlier reports of their substantial resistance to this pest. Providing access to diverse germplasm will help farmers react to increasing pest pressure, while still allowing for high marketable yields. In addition, breeding and selection for pest resistance could be an important addition to integrated pest management of sweetpotato in Hawai‘i.
PASSIVE-SAMPLER EMPLOYED FOR ANTIFOULING BOOSTER BIOCIDES ANALYSES IN SEAWATER
Authors: Freitas Marta , Batista Rodrigo , Costa Andressa , de Amarante Junior Ozelito , Franco Teresa , Fillmann Gilberto , Brito Natilene
Published: June 2024

The antifouling booster biocides are frequently studied for toxic effects on the aquatic ecosystems. The present investigation proposes passive silicone rubber samplers as a collection method for biocides, once these methods can concentrate substances in aqueous matrices at very low levels. Through the passive sampler-water partition coefficient (Ksw) and the analyte chemical nature, we can optimize their extraction from the membrane to apply in the sample medium. We used the co-solvent method to determine the Ksw of three third-generation antifouling biocides, chlorothalonil, dichlofluanid, and dichlorooctylisothiazolinone (DCOIT), with log Ksw = 2.24, 4.01, and 2.38, respectively. Improving extraction also led to a recovery range higher than 70%, determinations were carried out by gas chromatography with an electron capture detector. Biocides concentration in seawater samples from Itaqui port (São Marcos Bay, northern Brazil) ranged from 0.058 to 0.72 μg L-1 for chlorothalonil, 0.001 to 0.008 μg L-1 for dichlofluanid, and 0.018 to 0.64 μg L-1 for DCOIT.
Influência do substrato sobre a emergência e o crescimento inicial de plântulas de Couroupita guianensis Aubl., Lecythidaceae
Authors: BERNARDO SILVA KELINA , DE CALDAS PINTO MARIA DO SOCORRO , MOISES  , DAÍSLA DE LIMA DANIELLE
Published: June 2024

O abricó-de-macaco (Couroupita guianensis Aubl.) é árvore utilizada na arborização em centros urbanos e fazendas. O presente trabalho visou avaliar a influência de diferentes substratos sobre a emergência e o crescimento inicial de plântulas dessa árvore. O experimento foi realizado na Universidade Estadual da Paraíba (UEPB), em Catolé do Rocha (PB). O delineamento experimental utilizado foi inteiramente casualizado, com dez tratamentos e quatro repetições. As sementes foram semeadas nos seguintes substratos e/ou combinações: S1 – areia lavada; S2 – terra de subsolo; S3 – areia + húmus 1:1; S4 – areia + vermiculita 1:1; S5 – areia + pó de coco 1:1; S6 – areia + pó de madeira 1:1; S7 – terra de subsolo + húmus 1:1; S8 – terra de subsolo + vermiculita 1:1; S9 – terra de subsolo + pó de coco 1:1 e S10 – terra de subsolo + pó de madeira 1:1, em quatro repetições de 25 sementes. Foram determinados: porcentagem de emergência, índice de velocidade de emergência, comprimento de parte aérea e raiz principal, massa seca de parte aérea e raízes de plântulas. A combinação areia + vermiculita (S4) e o substrato terra de subsolo (S2) foram os mais eficientes na emergência e no crescimento inicial das plântulas.
Crotalus durissus Linnaeus, 1758 em São Paulo, Brasil: um estudo sobre distribuição, hábitat e desafios de preservação
Authors: Torres de Medeiros Marcelo Henrique , Gomes dantas Marcus Vinicius , Soares Pedro Lucas
Published: June 2024

Entre as 430 espécies de serpentes registradas para o Brasil, Crotalus durissus Linnaeus, 1758 é a única cascavel que ocorre no país. O objetivo geral deste trabalho é investigar a distribuição de ocorrência da serpente C. durissus no estado de São Paulo e a relação da distribuição com a cobertura vegetal. A análise engloba as adaptações da espécie à variedade de ambientes, com ênfase em sua preferência principalmente por áreas de cerrado. A metodologia inclui o uso da plataforma GBIF para coleta de dados, o uso do sensoriamento remoto para aquisição de dados de vegetação, do software R para limpeza e tratamento dos dados e do programa Qgis para a elaboração de mapas. Os resultados apontam a degradação do hábitat, particularmente relacionada à expansão de áreas agrícolas de café e cana-de[1]açúcar. Essa expansão é um dos principais fatores que influenciam o alcance da espécie. São propostas medidas de conservação que incluem a criação e a gestão de áreas protegidas, tais como parques nacionais, e a implementação de práticas de monitoramento e preservação da espécie e da biodiversidade.
Ambiente aeroportuário e o risco de acidentes aeroviários por colisão com fauna em Joinville, SC, Brasil
Authors: Caroline Aparecida de Souza  , Denise Monique Dubet da Silva Mouga
Published: June 2024

A avaliação de risco de acidentes com fauna em aeroportos constitui ferramenta para a gestão dos ambientes aeroportuários. Nesse contexto, estudou-se o aeroporto de Joinville, examinando dados de ocorrência de colisões com fauna reportados ao Cenipa para o período de 2011 a 2020. Foram averiguadas as espécies de animais que colidiram, as condições meteorológicas nos momentos de colisão, os modelos de aviões, a periodicidade das colisões e a prevalência dos acidentes. Verificou-se que a ave quero-quero (Vanellus chilensis) é a que mais ocasiona colisões, seguida pela ave corucão (Chordeiles nacunda) e pela andorinha-de-sobre-branco (Tachycineta leucorrhoa). As espécies com maior número de colisões também são as mais encontradas na área aeroportuária. Animais terrestres envolveram-se em colisão (répteis, cachorro doméstico e cachorro selvagem). Os anos com maior número de colisões foram aqueles com maior quantidade de voos. O período do dia com maiores colisões foi o diurno. Em dias de céu claro, ocorreram mais colisões entre aves e aviões, assim como em dias sem nenhuma precipitação. Houve diferença significativa para as colisões no horário entre 7h e 8h. As colisões ocorreram em maior quantidade em aviões turbofan.
JOGO COM ENCAIXE DE ANIMAIS DOS BIOMAS BRASILEIROS
Authors: De Morais Ronaldo Pinheiro , Silva Marcos Estácio Santos , Pazmino Ana Veronica
Published: June 2024

Este artigo apresenta o desenvolvimento de um material voltado ao aprendizado de crianças na faixa etária de 6 meses a 5 anos de idade, para a brinquedoteca do Hospital Universitário da Universidade Federal de Santa Catarina (UFSC). O objetivo é desenvolver um brinquedo/jogo lúdico e facilmente higienizável. A prática projetual utilizou diversos métodos para identificar as necessidades de crianças e seu processo de aprendizado, em diversos âmbitos, tanto motor quanto sensorial, e consistiu em uma pesquisa realizada com uma visita até o referido ambiente. O resultado é um tabuleiro, com ênfase no design social e ambiental, que possui peças simples encaixáveis e de fácil manuseio representando alguns animais dos biomas brasileiros em seus respectivos hábitats. O intuito é auxiliar essas crianças na brincadeira e no conhecimento de alguns animais nativos e que devem ser protegidos.
Resenha do Livro “Ensino (e aprendizagem) as Lutas”
Authors: Mocarzel Rafael Carvalho da Silva
Published: June 2024

Resenha do livro “Ensino (e aprendizagem) das lutas”, escrito pela professora Dra. Mariana Simões Pimentel Gomes e publicado em 2023 pela editora Appris (Brasil). A obra traz à luz um dilema tradicional e contemporâneo de professores e pesquisadores do universo das Lutas, Artes Marciais e Esportes de Combate (LAMEC): unir harmonicamente práticas tradicionais das LAMEC com novas possibilidades pedagógicas refletidas e propostas no universo acadêmico em geral. Para tal, de maneira mais específica, analisou (in loco) e comparou o contexto universitário do ensino de LAMEC tanto no Brasil quanto na França.
Recent Innovations in Synthetic Methodologies and Patent Landscape of Quinoline Analogues: A Comprehensive Review
Authors: Goel Tanvi Rajiv , Salahuddin  , Rana Kavita , Mazumder Avijit , Kumar Rajnish , Ahsan Mohamed Jawed , Sarafroz Mohammad , Tyagi Pankaj Kumar , Singh Saurabh
Published: June 2024

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Quinoline is a general group of heterocyclic compounds that have garnered much
interest in medicinal chemistry and drug development due to their wide range of pharmacological
effects. Pyridine ring fused with benzene defines the class of chemical compounds
known as quinolines. Quinoline is a weak tertiary base, also known as 1-aza-naphthalene.
Numerous patents have been filed for the synthesis of quinoline-based compounds, discussing
about their derivatives and uses. Here, we have discussed the methods of quinoline synthesis,
structural alterations, and patents showing its importance in various industries. Quinolines
have been investigated as antimalarial substances, with substances, like quinine and
chloroquine, serving as notable examples, and they have also been investigated to possess
anti-inflammatory, anti-tumor, and CNS activity. The synthesis of quinoline is also subjected
to several recognized procedures. The variations in the ring system and various synthetic approaches are the
key highlights of the article, and it includes the various catalysts that could be recycled and reused by the assisted
technique, which increases the yield and requires less time for the synthesis (ultrasound-promoted synthesis,
one-pot reaction, and microwave and photocatalytic reactions). The development of synthetic procedures can
help in the sustainable synthesis of quinoline derivatives.
Emerging Trends in Hybrid Nanoparticles: Revolutionary Advances and Promising Biomedical Applications
Authors: Bhardwaj Harish , Khute Sulekha , Sahu Ram Kumar , Jangde Rajendra Kumar
Published: June 2024

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Modern nanostructures must fulfill a wide range of functions to be valuable, leading to the combi-nation of various nano-objects into hierarchical assemblies. Hybrid Nanoparticles (HNPs), comprised of mul-tiple types of nanoparticles, are emerging as nanoscale structures with versatile applications. HNPs offer en-hanced medical benefits compared to basic combinations of distinct components. They address the limitations of traditional nanoparticle delivery systems, such as poor water solubility, nonspecific targeting, and subopti-mal therapeutic outcomes. HNPs also facilitate the transition from anatomical to molecular imaging in lung cancer diagnosis, ensuring precision. In clinical settings, the selection of nanoplatforms with superior repro-ducibility, cost-effectiveness, easy preparation, and advanced functional and structural characteristics is para-mount. This study aims toextensively examine hybrid nanoparticles, focusing on their classification, drug de-livery mechanisms, properties of hybrid inorganic nanoparticles, advancements in hybrid nanoparticle technol-ogy, and their biomedical applications, particularly emphasizing the utilization of smart hybrid nanoparticles. PHNPs enable the delivery of numerous anticancer, anti-leishmanial, and antifungal drugs, enhancing cellular absorption, bioavailability, and targeted drug delivery while reducing toxic side effects.
A Review on Therapeutic Strategies against Parkinson’s Disease: Current Trends and Future Perspectives
Authors: Papagiouvannis Georgios , Theodosis-Nobelos Panagiotis , Rekka Eleni A.
Published: June 2024

Parkinson’s Disease (PD) is the most common neurodegenerative disorder after Alzheimer’s
Disease and is clinically expressed by movement disorders, such as tremor, bradykinesia,
and rigidity. It occurs mainly in the extrapyramidal system of the brain and is characterized by dopaminergic
neuron degeneration. L-DOPA, dopaminergic agonists, anticholinergic drugs, and
MAO-B inhibitors are currently used as therapeutic agents against PD, however, they have only
symptomatic efficacy, mainly due to the complex pathophysiology of the disease. This review
summarizes the main aspects of PD pathology, as well as, discusses the most important biochemical
dysfunctions during PD, and presents novel multi-targeting compounds, which have been tested for
their activity against various targets related to PD. This review selects various research articles from
main databases concerning multi-targeting compounds against PD. Molecules targeting more than
one biochemical pathway involved in PD, expected to be more effective than the current treatment
options, are discussed. A great number of research groups have designed novel compounds following
the multi-targeting drug approach. They include structures combining antioxidant, antiinflammatory,
and metal-chelating properties. These compounds could be proven useful for effective
multi-targeted PD treatment. Multi-targeting drugs could be a useful tool for the design of effective
antiparkinson agents. Their efficacy towards various targets implicated in PD could be the
key to the radical treatment of this neurodegenerative disorder.