bluuebunny/crossref_metadata_2025 huggingface dataset:
The usefulness of re-attachability of anti-adhesive cross-linked gelatin film and the required physical and biological properties
Authors: Horii Tsunehito , Tsujimoto Hiroyuki , Kageyama Susumu , Yoshida Tetsuya , Kobayashi Kenichi , Takamori Hideki , Minato Hiroshi , Ueda Jo , Hagiwara Akeo , Ichikawa Hiroshi , Kawauchi Akihiro
Published: November 2020

BACKGROUND: To overcome the unfavorable issues associated with conventional anti-adhesive HA/CMC film, we developed an anti-adhesive thermally cross-linked gelatin film. OBJECTIVE: We tried to clarify the re-attachability of the film and the required properties concerning the film thickness, stiffness and anti-adhesion effect. METHODS: To determine the optimal thickness, 5 kinds of the thickness of gelatin film and the conventional film were analyzed by the tensile test, shearing test, buckling test and tissue injury test. Finally, using the optimal film thickness, we tried to clarify the anti-adhesion effect of the reattached film. RESULTS: The tensile and shearing test showed gelatin films ≥30 μm thick had greater tensile strength and a smaller number of film fractures, than the conventional film. The buckling and tissue injury test showed gelatin films ≥60 μm thick had higher buckling strength and worse injury scores than the conventional film. The anti-adhesive effect of re-attached gelatin film using optimal thickness (30–40 μm) found the anti-adhesion score was significantly better than that of the control. CONCLUSIONS: Provided it has an optimal thickness, gelatin film can be reattached with enough physical strength not to tear, safety stiffness not to induce tissue injury, and a sufficient anti-adhesion effect.
Relationship between applied force and magnetic field in a pseudo-static test of a portal frame
Authors: Guo Huan , Su Sanqing , Wang Wei , Ma Xiaoping , Yi Shuchun , Zhao Xuran
Published: November 2020

Metal magnetic memory (MMM) testing is a nondestructive approach for evaluating the stress concentration and early damage of ferromagnetic components. However, research on the MMM testing of large steel structures has been limited. Thus, this study investigates the suitability of MMM technology for monitoring the damage in steel structures exposed to complex stresses. The normal components of magnetic signals Hp(y) on the beams and columns of a portal frame are obtained through pseudo-static testing. The signal increment ΔHp(y) and its absolute value |ΔHp(y)| under different loads are analyzed. The relationship between the equivalent stress and magnetic signal is investigated through numerical simulation. The results show that the ΔHp(y) curves are similar during the elastic stage but change abruptly during the plastic phase. Moreover, the differences in the magnetic signal directions caused by the varying detection directions cannot be ignored. In the elastic stage, with the increase in the load, |ΔHp(y)| curves initially increase and then decrease. The formation of the ΔHp(y) curve is similar to the distribution of the equivalent stress. The mutation of ΔHp(y) can determine whether a specimen is entering the plastic phase, and can warn against structural failure. The magnetic signal distribution qualitatively reflects the stress distribution.
Mutual influence of the faces contact area and the pre-fracture zone near the tip of the interfacial crack
Authors: Dudyk M.V.
Published: November 2020

BACKGROUND: Under plane strain conditions, a crack model was developed on a plane interface between two different materials, which assumes the existence near its tip of the faces contact area and a narrow lateral pre-fracture zone in a less crack-resistant material of the composite compound. The pre-fracture zone is modeled by the line of normal displacement rupture, on which the normal stress is equal to the tensile strength of the material. Assuming that the dimensions of the pre-fracture zone and the contact zone have the same order of magnitude and are significantly smaller than the crack length, the problem is reduced to the vector Wiener–Hopf equation. METHODS: An approximate method for solving the vector Wiener–Hopf equation was developed, which was used to obtain the equations for determining the sizes of the pre-fracture zone and the contact faces area. The pre-fracture zone orientation was determined from the condition of the potential energy maximum accumulated in the zone. Numerical calculations of the indicated parameters and analysis of their dependences on the configuration and module of external load are executed. RESULTS: A significant mutual influence of the pre-fracture zone and crack faces contact on their sizes and orientation of the zone was revealed.
ALLELOPATHIC EFFECT OF Sorghum bicolor AND Digitaria insularis ON GERMINATION AND INITIAL DEVELOPMENT OF CANOLA
Authors: Campos Thiago Souza , Sousa Ane Gabriele Vaz , Rego Junior Jaime Santos do , Sousa Westefann dos Santos , Benett Cleiton Gredson Sabin , Arruda Natália
Published: November 2020

Agriculture depends on biotic and abiotic factors, and one of them is allelopathy, defined as the chemical interference that one plant has on others, which can negatively affect germination. The objective of this work is to evaluate the allelopathic effects of Sorghum bicolor and Digitaria insularis on seed germination and initial development of canola seedlings (Brassica napus L.). A completely randomized design was used in a 2x5 factorial scheme (two extracts: D. insularis and S. bicolor) and five concentrations (0, 25, 50, 75, and 100%), with four replicates of fifty seeds, the plot being constituted by a 'gerbox' box containing 50 seeds evenly distributed. The variable analyzed were germination percentage (G), abnormal seedlings (AS), dead seeds (DS), length of the shoot (SL) and primary root (RL), total length (TL) of the seedling, shoot ratio (S/T), and root ratio (R/T). The aqueous extracts of D. insularis interfere in all variables studied, which compromises the formation of normal seedlings, regardless of concentration. The extract of S. bicolor expressed allelopathic effects only in concentrations above 75%. Both species can inhibit the initial development of canola plants.
Imunoterapia em Oncologia em uma Cidade do Interior de Minas Gerais: Análise da Década 2010-2019
Authors: Campos Camila Silveira , Bessa Fernanda Lopes , Melo Isabelle Fernanda Ladeira de , Esteves Luana França , Messias Marcella Rodrigues , Souza Sávia Gabriela Tameirão Pedroso Gregório de , Pujatti Priscilla Brunelli
Published: November 2020

Introdução: Nos últimos anos, a terapia sistêmica em oncologia sofreu mudanças substanciais e a imunoterapia destacou-se como forma de tratamento adjuvante. No Brasil, as diferenças do acesso a essa terapêutica podem ser observadas de maneira relevante e ainda não há amplo conhecimento sobre o seu uso nas diferentes Regiões do país. Objetivo: Analisar o panorama da utilização de imunoterapia no tratamento oncológico em Barbacena-MG na última década. Método: Estudo descritivo de centro único. Os pacientes maiores de 18 anos, diagnosticados com câncer e que utilizaram imunoterápicos no período de 2010 a 2019, foram selecionados por meio de consulta ao Registro Hospitalar de Câncer, e as informações constantes nesse sistema, bem como prontuários, foram utilizadas para obtenção de dados sociodemográficos e clínicos. Resultados: A imunoterapia foi utilizada no tratamento de 90 pacientes (4,9%), totalizando 95 tratamentos. Entre os medicamentos utilizados, destacaram-se o Bacillus Calmette-Guérin (BCG), o trastuzumabe e o imatinibe. Observou-se um aumento na utilização de imunoterápicos ao longo da década, bem como uma maior variedade de tratamentos realizados. O imatinibe e o pazopanibe obtiveram maior porcentagem de óbitos durante o tratamento e 77,9% dos medicamentos utilizados foram custeados pelo Sistema Único de Saúde (SUS). O tempo de tratamento da maioria dos pacientes se manteve próximo a dez meses, sendo menor para aqueles que se trataram com BCG. Conclusão: O uso da imunoterapia em oncologia em Barbacena apresentou um avanço no período de 2010 a 2019, tanto no quantitativo quanto na variedade de tratamentos, com incorporação de novos medicamentos.
Analysis of the ratio of livestock and livestock production by farms of Lviv region at the turn of the century
Authors: Shulskyi M.
Published: November 2020

The end of the XX and the beginning of the XXI centuries were characterized by radical changes in all spheres of social relations. During this period there was an intensive process of breaking the socialist systems of economic activity and the transition to a market economy. These changes can be fully attributed to the epoch-making, because there have been radical changes in all components of various spheres of social relations. Regarding the digital information used in the analysis of the presence of livestock in farms of Lviv region, it is reasonable to say that during the study period significantly decreased the number of farm animals in all categories of farms and in terms of enterprises and households. Regarding the indicators of livestock production in economic entities of Lviv region, the situation here is almost similar in terms of changes in the number of farm animals. The essence of the problem of this study is to analyze the effects of economic processes on the state of livestock development in Lviv region. At the same time, we have selected the main components of the functioning of the industry, namely: the presence of livestock and the volume of livestock production. These indicators are important and form the basis of the industry and therefore they are chosen as the basis that forms the essence of the problem. Our research should encourage scientists to conduct further research on the state of development of animal husbandry with a focus on identifying the causes that inhibited and inhibit the effective functioning of the livestock industry. The obtained research results should become an effective basis for managers and specialists to make rational management decisions to eliminate certain inhibitory factors in the development of animal husbandry.
Determination of the activity of fungicides against pathogens of dermatomycoses in domestic animals
Authors: Kushnir I. M. , Kushnir V. I. , Gutyj B. V. , Semen I. S. , Murska S. D. , Kolodiy G. V. , Berbeka U. Z.
Published: November 2020

The aim of the study was to identify and identify the causative agents of dermatomycosis in dogs and cats and to determine their sensitivity to solutions of ketonazole and chlorhexidine digluconate, which are part of the drug Skinhard. This is a spray for external use, manufactured by PJSC “Halychpharm”. For laboratory diagnosis of dermatomycoses, samples from the affected parts of the skin and fur of domestic animals were used. To isolate a pure culture of fungi were sown on selective media: wort agar, agar Saburo, Chapek. The optimal cultivation regime for pathogenic fungi was 20–25 °С. Isolated fungal cultures were identified by the appearance and shape of colonies, their consistency, color, ability to grow at 37 °C, microscopic structure, in particular - the nature of mycelial branching and the presence of septa, location of conidiophores, spores and other signs. A microbiological examination of the affected areas of the skin of dogs and cats was performed to detect microscopic fungi. The following fungi were isolated from dogs affected by mycoses: Candida spp., Aspergillus niger, Epidermophyton spp., Microsporum spp., Mucor spp., Trichophyton spp., Mallasseria spp., Sporotrich spp, Candida albicans, and from cats: Microspor Candida spp., Spototrich spp., Rhizorus spp., Fusarium spp. Trichophyton spp. Isolated microscopic fungi of the genus Malassezia spp. belong to superficial mycoses (keratomycoses) and affect the superficial layers of skin and hair. Epidermatophytes: Trichophyton spp., Epidermophyton spp., Microsporum spp. affect the epidermis, skin and coat. In addition, opportunistic fungi of the genus Aspergillus spp, Mucor spp., Rhizorus spp. and Fusarium spp. Chlorhexidine digluconate was found to be highly active against dermatophytes (Trichophyton spp., Microsporum spp.), Less active against fungi of the genus Candida and less active against Aspergillus spp, Mucor spp., Rhizorus spp, Fusarium spp. Ketonazole is highly active against dermatophytes (Trichophyton spp., Epidermophyton spp., Microsporum spp.), Yeast (Malassezia spp., Candida spp.,) And opportunistic fungi (Aspergillus spp., Mucor spp., Rhizorus spp.).
Some aspects of the occurrence and development of chronic aseptic pododermatitis in highly pregnant cows
Authors: Khomyn N. M. , Mysak A. R. , Tsisinska S. V. , Pritsak V. V. , Nazaruk N. V. , Lenjo Yu. M.
Published: November 2020

Pododermatitis in tall cows that occur on the background of secondary osteodystrophy can lead to significant economic losses, consisting of forced culling of animals, reduced milk yield, reproductive function and not enough receiving of calves. Therefore, the question of studying the peculiarities of origin and development, in particular chronic aseptic pododermatitis in these animals is quite actual. It is defined that with the same type of highly concentrated feeding, hypodynamics and insufficient insolation in the organism of highly pregnant cows, the process of assimilation of feed minerals is disrupted  (develops, as is known, for dysfunction of the endocrine glands due to prolonged ketosis), which is appeared by resorption of the hoof bone, low rates of mass-volume extraction analysis of bone biopsy and testifies a systemic violation of mineral metabolism in animals and is confirmed by biochemical parameters, in particular, the concentration in the hoof horn of individual macro-and trace elements, as well as biophysical parameters of the epidermis of the hooves. Thus, the concentration of Calcium in the hoof horn is 16.8 % lower than in clinically healthy animals, Sulfur – by 20.3 %, Copper – by 16.2, Zinc – by 15.0, Cobalt – by 13.0 with increasing concentration of sulfhydryl groups by 34.3 % and moisture, respectively – by 5.5 %, which causes a decrease in the density and hardness of the epidermis of the hooves by 5.4 % and 19.0 %, respectively, and contributes to the deterioration of the quality of the hooves of highly pregnant cows. Such changes lead to deformation of the hooves, violation of the uniform load on their soles and the development of aseptic inflammation of the skin base of the hooves of a chronic nature, because the process of metabolic disorders occurs over a long period of time.
Morphological composition of blood and clinical indicators in ball fattening on the effect of b vitamins (В1, В2, В5, В6, В10, В12)
Authors: Golovach P. I. , Zmiya M. M. , Pokotylo S. O.
Published: November 2020

In realization of the genetic productivity potential of different species of farm animals, an important place is given to full feeding. Insufficient supply of farm animals with individual vitamins has negative impact on the activity of the relevant enzyme systems, hormonal status, metabolism of nutrients, the state of the natural resistance of the various organs and organ systems, the processes of adaptation and productivity level. Numerical searches have shown that farm animals need in different vitamins depends on the type, age, sex, physiological state, the season, the level of productivity and others. According to some reports ruminants have been providing with water-soluble B vitamins  by their rumen microbial synthesis accordingly it was recommended to rations setting for cattle, sheep and goats, along with nutrients and minerals only by carotene and vitamins D and E. Specific features of the effect of different doses of complex B vitamins (thiamine hydrochloride, riboflavin, niacin, pyridoxine hydrochloride, folic acid, ciankobalamin in venous blood) on morphological composition (erythrocytes, leukocytes, platelets, hemoglobin, hematocrit, erythrocyte sedimentation rate) and clinical indicators (heart rate, respiratory rate, type temperature) at the final stage bull fattening. Studies have shown that the addition to the diet of calves for fattening balanced nutrients and minerals and fat-soluble vitamins A, D, E complex of B vitamins (В1, В2, В5, В6, В10, В12) in appropriate doses generally positive effect on erythrocytes, leukocytes, hemoglobin, hematocrit, dose-dependent additionally introduced into the diet of B vitamins (В1, В2, В5, В6, В10, В12). The basis for our dosage of various B vitamins for Bovine experimental groups on fattening is the corresponding percentage of the recommended doses of certain B vitamins for fattening pigs (10 % – D1, 20 % – D2, 40 % – D3, 60 % – D4 group). The biggest change in terms on morphological composition in animals 3rd ((В1 – 0,040; В2 – 0,06; В5 – 1.2; В6 – 0.25; В10 – 0.0030; В12 – 0.0006 mg/kg body weight) and 4th (В1 – 0.070; В2 – 0.10; В5 – 2.0; В6 – 0.40; В10 – 0.0050; В12 – 0.0010 mg/kg body weight) research groups, and smallest – in bull 1st (В1 – 0.015; В2 – 0.03; В5 – 0.5; В6 – 0.10; В10 – 0.0012; В12 – 0.0002 mg/kg body weight) and 2 th (В1 – 0.025;  В2 – 0.04; В5 – 0.8; В6 – 0.15; В10 – 0.0020; В12 – 0.0004 mg/kg body weight) research group, which is associated with dose introduced to the diet of calves during the final fattening phase of B vitamins (В1, В2, В5, В6, В10, В12).
The effectiveness of methods for laboratory diagnosis of otodectosis in dogs
Authors: Korchan L. , Zamaziy A.
Published: November 2020

Otodectosis in domestic dogs is caused by ectoparasites of the species Otodectes cynotis (Hering, 1838), which parasitize on the inner surface of the auricles, the external auditory canal and the eardrum. The invasion is accompanied by severe itching, otitis, anxiety of animals, and sometimes – their death due to complications. The effectiveness of measures to combat otodectosis in dogs largely depends on the correct and accurate diagnosis of the invasion. At the same time, existing laboratory methods have different diagnostic efficiency. The aim of the study was to establish the effectiveness of mortal and vital methods of lifelong diagnosis of otodectosis in dogs. The effectiveness of modern methods of laboratory diagnosis of live and dead ticks of the species O. cynotis in dogs has been established. The most effective methods have been identified, the use of which will improve the quality of acarological research. Studies have shown that the most effective method of mortal methods was A. M. Titarenko, where a mixture of 50% aqueous solution of glycerin, dimethyl sulfoxide and 10% sodium hydroxide solution (the intensity of the invasion was 5.4 specimens of mites) was used as an illuminator. This method exceeded the intensity of invasion using the compressor method – 2 times (2.7 specimens of mites, P < 0.001), the flotation method – 1.2 times (4.5 specimens of mites). At the same time, the flotation method for otodectosis in dogs was 1.7 times more effective (P < 0.001) than the use of the compressor method. Of the vital methods of laboratory diagnosis of otodectosis in dogs, the most effective was the method using vegetable oil as a scraper clarifier, the intensity of the invasion was 5.9 copies. ticks. The use of this technique in terms of the number of detected otodectes exceeded the method of A.V. Alfimova (influence of elevated temperature) – 2.1 times (2.8 specimens of mites, P < 0.001) and the method of M.G. Khatin (centrifugation under the influence of elevated). temperature) – 1.3 times (4.6 specimens of mites, P < 0.001). In addition, the congratulatory method of M. G. Khatin in the diagnosis of otodectosis was 1.6 times more effective (P < 0.001) than the method of A. V. Alfimova.
Research antianemic action of the iron (IV) clathrochelate complexes on the sickling piglets
Authors: Dukhnitskyi V. B. , Derkach I. M. , Derkach S. S. , Fritsky I. O. , Plutenko M. O. , Lozovyi V. M. , Kostrub V. V. , Losa Y. V.
Published: November 2020

A lot of antianemic drugs for animals are presented on the modern pharmaceutical market of veterinary medicine, but they have several drawbacks. So finding new drugs with goal to treat ill animals by anemia and to prevent the iron deficiency anemia is a pressing issue. We previously reported the results of preclinical studies of iron in rare high valence IV. This allowed us to determine, supplement, and generalize the data on clinical studies of the new drugs with the active substance iron (IV) clathrochelate. Therefore, the article presents the results of studies of its antianemic effect on sickling piglets. Experiments were carried out on piglets-analogues neonates, which were divided into three groups: control and two experimental groups. Piglets were kept with sows on suckling. For the purpose of prevention iron deficiency anemia the traditional solution of iron dextran was administered once intramuscularly to piglets of I control group. The aqueous solution of iron (IV) clathrochelate complexes was administered once intramuscularly to piglets of II experimental group. Iron (IV) clathrochelate complexes was dissolved in a solvent of rheopolyglucin and administered once intramuscularly to piglets of III experimental group. 1 mL of test solutions contained 100 mg of active substance. The investigative material were the samples of blood and serum of piglets, their liver and spleen. The experiment lasted during a 30-day period since birth of piglets. According to the results of the experiments, iron (IV) clatrochelate complexes which was dissolved in a water for injection and rheopolyglucin had higher antianemic activity compared to the control. This is evidenced by the dynamics of probable changes in the number of erythrocytes, hemoglobin content and hematocrit, Iron content in serum and its mass fraction in the blood, liver and spleen of piglets. The effectiveness of the action of iron (IV) clatrochelate complexes is explained by the full supply of piglets with iron and its higher bioavailability.
GREEDY METHOD FOR SOLVING THE LANGKAWI TOURIST ROUTE: A CASE STUDY
Authors: Hashim Zakiah , Mat Desa Wan Laailatul Hanim , Aziz Hurul Ain , Mohd Zaki Nur Mariana Zaimah
Published: November 2020

This paper presents a real case study to determine the optimal tourist route at Langkawi Island. The Langkawi Island was selected as thecase study because normally, tourist travel to this island will drive the rented car as the primary mode of transport. Thus, the aim of this paper is to develop a mathematical model to find an optimal route for tourist to travel to their interesting places around Langkawi Island. In order to solve the problem, Greedy method was applied in this study and MATLAB version 7.8 has been used to get the solution. The result obtained shows that Nearest Greedy Insertion method gives better result compared to the Nearest Greedy method. The minimum value of the route selection gives effect to the cost of travelling. Therefore, from this study, the best route that connect from one interesting place to others place can be suggested to the tourist as guidance. In addition, tourist can save their time and money to visit all interesting places in this study.
STRATEGIC INNOVATIONAS DRIVER FOR SME PERFORMANCE IN YEMEN
Authors: AlQershi Nagwan , Abas Zakaria , Mohd Mokhtar Sany Sanuri
Published: November 2020

Success lies at the heart of every organization’s ability to innovate, innovation is one of the most important strategies of competition, both for large and small firms, it is widely held in the literature and among practitioners that small and medium enterprises (SME) are instrumental in the economic development of countries worldwide. However, the contribution of SMEs can only be possible through performance. This study is a conceptual discussion of manufacturing SME performance in Yemen and the effect of strategic innovation. The performance is considered to be very low, andthe country is ranked by the Global Innovation Index as one the lowest in terms of innovation. The study discusses strategic innovation and presents a framework for understanding the concept in 10 different ways. It concludes by recommending some policiesthrough which the government of Yemen can assist manufacturing SMEs. Specifically, the study recommends that the government should provide training subsidies to manufacturing SMEs because innovation can only take place when human resources are adequately trained.
TRANSACTIONAL LEADERSHIPSTYLE ON TURNOVER INTENTION AMONG ELECTRICAL ANDELECTRONIC SUB-SECTOR EMPLOYEES IN MALAYSIA
Authors: Deraman Norita , Mad Nor Nik Norsyamimi , Zainuddin Nizamuddin
Published: November 2020

Job turnover is traditionally faced by organisations in many industries. Implications such as resources wastage and low productivity can be derivedfrom the turnoverissue. The turnoverintention was found to be a reliable predictor for actual turnover in previous studies. Consequently, this demands some insights on turnover intention issue, especiallywithin the Malaysiancontext. This paper will focus on determiningthe relationship oftransactional leadership styles on turnover intention among manufacturing operators, particularlyin Electrical and Electronics sub-sector. The study was conductedamongst the operators of manufacturing industry in Peninsular Malaysia (N=800). Consideringthat Malaysia manufacturing industry has shown a strongeconomic growth through substantialinvestment in economic activities, it is essentialfor all manufacturing companies to retain talented employees and reduce the turnoverproblem in order tobe moreproductive and competitive. The findings had accepted the research hypothesis. Dimensions of transactional leadership styles (i.e. contingent rewards, management-by-exception passive) significantly correlated and contributed to the turnover intention. Thefindings hadcontributed to the theoretical significance through the examination of direct relationships between transactional leadership styles on turnover intention among local operators in the manufacturingsector in Malaysia.
宿县闸安全鉴定分析及限制运用建议
Authors: 刘 树峻
Published: November 2020

水闸除险加固是防止水闸工程老化失修、积病成险的重要举措，也是落实国务院《水利工程管理体制改革实施意见》，推进水管体制改革的根本目标。为保证水闸安全正常运行，确保地区防洪安全，组织实施水闸安全鉴定是一项必需而重要的工作。本文结合宿县闸安全鉴定的组织实施过程，简要介绍安全鉴定的程序，对水闸安全方面进行分析评价，指出存在的问题，提出限制运用建议，进一步加强水闸的安全管理，充分发挥工程的综合效益。
水利水电施工中施工导流和围堰技术的应用分析
Authors: 阮 对平
Published: November 2020

近年来，在多方面利好因素的影响下，使得我国社会经济水平得到了全面的提升，为各个行业的发展壮大带来了良好的机遇。水利水电工程在社会发展中的作用是十分巨大的，水利水电工程的核心作用就是为社会的发展提供充足的水电资源，所以切实的保障水利水电工程质量是具有非常重要的现实意义的。在实际组织实施水利水电工程施工工作的时候，不仅要确保能够满足农业灌溉、发电和防洪的实际需要，并且也需要保证具备良好的环保作用。
水电站工程建设施工安全管理
Authors: 王 波涛
Published: November 2020

水电站工程关系着区域的社会发展与稳定，其建设需要投入较多的资金和人员，有着较长的施工周期，施工中危险因素较多，还存在很多高空等特种作业任务。为了保证水电站工程建设安全性，需要管理人员提高对安全管理工作的重视度，加强施工现场危险因素分析，采取有效的预防措施，保证水电站工程建设顺利完成。以卡里巴南岸扩机工程为研究对象，就如何加强水电扎工程建设安全管控展开分析，以期达到提高安全管理的效果。
OMRONCS1D系列模块在船闸自动化系统中的应用
Authors: 张 超 , 江 奎龙
Published: November 2020

文章论述了一种VB.NET实现和OMRON CS1D系列PLC之间的通讯实现。并成功的运用到安徽阜阳颍上船闸自动化控制系统中。主要实现上位机和OMRON CS1D系列PLC单元进行通讯以实现远程对闸阀门的开、关、停、急停、急停复位等的控制，同时对该通讯协议进行了描述。以实例出发，极具参考价值。该系统经实际运用，效果良好。
MODELING TEACHING IN STUDY OF GALVANIC CELLS: UPPER-SECONDARY SCHOOL CONTEXT
Authors: Lu Huanhuan , Jiang Yanxia , Bi Hualin
Published: November 2020

Besides improving students' understanding of scientific concepts, chemistry teaching should also improve students' ability of applying concepts to solve problems. The research aims to explore the effects of modeling teaching on students’ proficiency in solving galvanic cell problems. This research used a quasi-experimental design, and the independent variable of the research was the teaching method. Forty-five students in the experimental class received modeling teaching, and 48 students in the control class received lecture-style teaching. The dependent variable was the performance level of the student's ability to solve the problem of the galvanic cell, which was evaluated using the galvanic cell proficiency assessment tool. The research results show that the students in the experimental class were significantly more proficient in solving galvanic cell problems than those in the control class. The results of unstructured interviews assisted in illustrating the role of modeling teaching in improving the proficiency of students in solving galvanic cell problems, and students in the experimental class had positive views on modeling teaching. Keywords: galvanic cells, modeling teaching, problem solving, proficiency level
Physical and Chemical Properties and Quality Control Methods of Hyaluronic Acid (Review)
Authors: Amandusova A. Kh. , Savelyeva K. R. , Morozov A. V. , Shelekhova V. A. , Shestakov V. N. , Persanova L. V. , Polyakov S. V.
Published: November 2020

Introduction. This review describes the physicochemical properties that determine the use of hyaluronic acid in ophthalmology. We have studied methods for determining hyaluronic acid using various analytical methods.

Text. Hyaluronic acid is a high molecular weight glycosaminoglycan that consists of repeating disaccharides of N-acetylglucosamine and D-glucuronic acid. Carboxyl, hydroxyl and acetoamide groups give hydrophilic properties to the molecule of this anionic heteropolysaccharide. Depending on how the hyaluronic acid is obtained, its molecular weight varies over a wide range. Researchers developed methods for controlling hyaluronic acid, which include the turbidimetric titration method, the method of high-performance capillary electrophoresis and high-performance liquid chromatography and IR spectroscopic method.

Conclusion. Due to its properties, hyaluronic acid is widely used as an active ingredient in pharmaceutical preparations. Today, there are a number of methods for the determination of hyaluronic acid, including the method of turbidimetric titration, the method of capillary electrophoresis. High performance liquid chromatography (HPLC) and IR spectroscopy methods are presented in the Japanese Pharmacopoeia and the European Pharmacopoeia. These techniques are widely used due to their high reproducibility, accuracy, and relative simplicity.
N-nitrosamine Impurities in Medicines: Toxicity, Formation Pathways, Methods of Determination, and Limits (Review)
Authors: Shchetinin P. P. , Senchenko S. P. , Gordeev K. K.
Published: November 2020

Introduction. N-nitrosamine compounds are potent genotoxic agents in animal species and some are classified as probable human carcinogens. This group of genotoxic impurities was found in drugs such as angiotensin II receptor blockers, histamine H1 receptor antagonists, and synthetic antidiabetic drugs. This discovery caused a flurry of alarm in the global pharmaceutical industry and resulted in a series of international investigations trying to determine root causes of nitrosamine formation in medicinal products and to find ways to minimize risks associated with nitrosamine contamination.

Text. This paper provides an overview of the current state of the problem. It summarises the main pathways of N-nitrosamine formation in medicinal products at the stages from synthesis of active pharmaceutical ingredients to storage of finished pharmaceutical products. The paper describes the main mechanism responsible for the toxic effect of this group of impurities in human body. It also describes methods of extraction and analysis of N-nitrosamines found in medicinal products. It was demonstrated that high-performance liquid chromatography and gas chromatography-mass spectrometry are a golden standard for the detection of these contaminants. The paper also touches upon the main principles of setting limits for nitrosamine impurities in medicinal products.

Conclusion. The data presented give a picture of the root causes of N-nitrosamine formation in medicinal products, as well as current detection and control methods used worldwide. Meanwhile, the paper raises a key issue about the need to develop Russian standards that would control the purity of medicinal products in terms of N-nitrosamine impurities. For that end, it will be necessary to draw on the experience of the leading USA and EU regulatory authorities.
Neutral Lipids of Oats Fruit (Avena Sativa L.)
Authors: Yuldasheva N. K. , Gusakova S. D. , Nurullaeva D. Kh. , Farmanova N. T. , Zakirova R. P. , Kurbanova E. R.
Published: November 2020

Introduction. Lipids are a widespread group of biologically active substances in nature, making up the bulk of the organic substances of all living organisms. They accumulate in plants in seeds, as well as in fruits and perform a number of vital functions: they are the main components of cell membranes and the energy reserve for the body.

Aim. Study of neutral lipids of sown oats (Avena sativa L.).

Materials and methods. The objects of the study were fruits (grains) of oats of the sown variety "Tashkent 1," harvested in the Republic of Uzbekistan.

 Results and discussions. Neutral lipids of oat grains have been found to contain 13 fatty acids with a predominance of the sum of oleic, linolenic and linoleic acids. The total degree of unsaturation was almost 78%. Absorption bands characteristic of these substances were observed in the IR spectrum of MEGC.

Conclusion. According to the results of the NL analysis, oat grains consisted of triacylglycerides and free LCDs, which were accompanied by hydrocarbons, phytosterols, triterpenoids and tocopherols.
Development and Validation of Dimeric Macrocyclic Tannin Assay Method in Dosage Forms
Authors: Ignаteva E. V. , Yartseva I. V. , Shprakh Z. S. , Prosalkova I. R. , Sasov S. A. , Orlova O. V.
Published: November 2020

Introduction. Quantitative assessment of the active substance is necessary and perhaps the most significant part of the drug quality control. Validation of the analytical methods of quantitative assessment ensures their compliance with high requirements. The present study describes the development and validation of a spectrophotometry method for the quantitative evaluation of the active substance in the drug form of the national antitumor and antiangiogenic drug «Dimeric macrocyclic tannin (DMT) lyophilizate for solution for injection, 100 mg».

Aim. The development and validation of the assay method for the standardization of «DMT lyophilizate for solution for injection, 100 mg».

Materials and metods. The study used «DMT lyophilizate for solution for injection, 100 mg» and the active substance DMT. Method – spectrophotometry.

Results and discussion. The methodof the quantitative assessment of the active substance in the DMT lyophilized drug by direct UV spectrophotometry was developed and the validation characteristics of the method were defined as a result of the study.

Conclusion. The validation results showed that the assay method of DMT in the drug form has the appropriate accuracy, precision and linearity. The obtained results correspond to the approved criteria that allow the use of the developed methodology for evaluating the quality of the drug.
Cell biology for visually impaired people: a study on inclusion methodologies
Authors: Santos Ruan Pablo Vieira , Reis Francisco Prado , Andrade Joana Angélica Melo de , Feitosa Vera Lúcia Corrêa
Published: November 2020

Introduction: Inclusive Education is a consequence of changes in social attitudes that have been established throughout history. Objective: This study analyzed the conceptions and practices of teachers who taught blind students and the benefits of using a didactic model (3D cell) adapted for these students. Methodology: 10 teachers were selected from the departments of Biology, Chemistry and Morphology at Universidade Federal de Sergipe. As for the 3D cell analysis, three visually impaired students from Biology, Physical Education and Physiotherapy courses were invited. Results: The research demonstrated the main weaknesses in the teacher training process and the little support they receive, thus leading to difficulties in the learning process and the relevance that didactic models can have in this context. Conclusion: Considering that theoretical and methodological foundations of Inclusive Education are based on a conception of quality education for the whole society, a more qualified teachers’ participation is essential to meet the educational needs of all students, with or without disabilities.
O que falar para a família? A predisposição para o câncer infantil hereditário
Authors: Cebulski Jenifer Nascimento da Silva , Couto Leila Leontina do
Published: November 2020

Objetivo:  Identificar o conhecimento de familiares sobre a doença infantil com predisposição hereditária ao câncer e analisar como a informação da doença é difundida no cenário intrafamiliar. Metodologia: Pesquisa qualitativa, exploratória. A coleta de dados foi desenvolvida com 16 familiares de crianças matriculadas no ambulatório de aconselhamento genético, através de entrevista individual, semi-estruturada com análise temática. Resultados: O desconhecimento sobre a doença com predisposição hereditária esteve presente no discurso dos familiares. Foram identificadas algumas estratégias de comunicação desenvolvida pelos familiares para a criança e familiares distantes. As informações obtidas no aconselhamento genético influenciaram na identificação de familiares de risco hereditário e cuidados com gerações futuras. Conclusões e implicações para a prática: A comunicação esteve presente no ambiente familiar com a criança e familiares diante da doença com predisposição hereditária ao câncer. Os profissionais de saúde necessitam se capacitar na área de oncologia genética para contribuir na identificação de crianças e famílias afetadas. As informações adquiridas no ambulatório de aconselhamento genético contribuem para o rastreamento de casos familiares, difusão da informação e na qualidade de vida dos afetados.
Estudo teórico e experimental da secagem de banana inteira em estufa
Authors: Farias Raimundo Pereira de , Silva Wilton Pereira , Magalhães Hortência Luma Fernandes , Lima Wanderson Magno Paiva Barbosa de , Gomez Ricardo Soares , Lima Elisiane Santana de , Silva Stephane Katherine Barbosa Moura da , Lima Antonio Gilson Barbosa de
Published: November 2020

Bananas frescas são frutas com elevado teor de umidade após a colheita, e são submetidas ao processo de secagem para minimizar desperdício e a deterioração, e aumentar a vida de prateleira. Este trabalho apresenta um estudo de secagem de banana em estufa. As bananas inteiras foram descascadas manualmente e secas nas temperaturas de 50 e 60ºC. Modelos concentrados de transferência de calor e massa e variações do volume da banana foram propostos e ajustados aos dados experimentais apresentando uma boa concordância. Os resultados revelaram que a temperatura do ar de secagem e a relação área/volume afetam significativamente a secagem, aquecimento e encolhimento da banana.
Transtorno de processamento sensorial e os prejuízos no processo de aprendizagem de alunos com transtornos do espectro autista: Um recado para os professores
Authors: Bacaro Paula Edicléia França , Mori Nerli Nonato Ribeiro
Published: November 2020

A aprendizagem e o desenvolvimento da criança com Transtorno do Espectro do Autismo (TEA) estão atrelados a diversas situações que envolvem as funções psíquicas, físicas, emocionais e estruturais do desenvolvimento humano. Uma delas está relacionada ao Transtorno de Processamento Sensorial que pode prejudicar a aprendizagem das crianças com TEA. Para que a aprendizagem ocorra, com qualidade esperada, além de outros fatores, é necessário a harmonização das informações  que chegam ao cérebro e transformam-se em respostas adaptativas esperadas. Quando esse processo não ocorre com qualidade, são geradas respostas insatisfatórias; há, então, a disfunção sensorial, cuja característica é o prejuízo na detecção, na modulação ou na interpretação dos estímulos sensoriais. Esse prejuízo pode provocar comportamentos inadequados, os quais reduzem e impedem a participação qualitativa da criança nas atividades pedagógicas. A fim de entender essa problemática foi realizada uma intervenção pedagógica com cinco crianças com TEA, em processo de aquisição da leitura e escrita, em situações de carga sensorial baixa e alta. Os resultados da pesquisa, qualitativa do tipo intervenção pedagógica, demonstraram que é possível reduzir a carga sensorial e consequentemente favorecer a aprendizagem das crianças.  Assim, esse artigo tem o objetivo de enfatizar a importância do professor considerar o Transtorno de Processamento Sensorial em alunos com TEA, na elaboração das atividades pedagógicas e na sua prática de ensino, a fim de amenizar os prejuízos causados por ele na aprendizagem. Neste contexto destaca-se que cada criança com TEA apresenta uma condição específica de aprendizagem que exige do professor o conhecimento de novas práticas.
Atuação da equipe multiprofissional de saúde frente aos casos de abuso sexual em crianças e adolescentes
Authors: Silva Patrick Leonardo Nogueira da , Benfica Flaviane Rodrigues , Carvalho Liziane Marilia de , Santos Cláudio Luís de Souza , Miranda Fábio Batista , Galvão Ana Patrícia Fonseca Coelho , Fonseca Adelia Dayane Guimarães , Alves Carolina dos Reis , Oliveira Valdira Vieira de
Published: November 2020

Objetivo: caracterizar a atuação da equipe multiprofissional de saúde frente aos casos de abuso sexual em crianças e adolescentes. Método: estudo descritivo, exploratório, transversal, com abordagem quantitativa, realizado com 102 profissionais de saúde da Atenção Básica de uma cidade de Minas Gerais. Utilizou-se um questionário semiestruturado como instrumento de coleta de dados. Estes foram analisados conforme a epidemiologia analítica descritiva simples. Resultados: prevalência de profissionais do sexo feminino, entre 18 e 30 anos, agentes de saúde, ensino médio completo e tempo de serviço entre 1-3 anos. Apenas 28,4% atenderam vítimas de abuso sexual, cuja prevalência foi de adolescentes entre 12-18 anos. Da amostra, 85,2% relatam saber identificar o abuso sexual; 74,5% observam o comportamento das crianças e adolescentes durante visitas domiciliares; 60,7% comunicam ao superior e 36,2% informam ter um fluxograma de atendimento, porém não se encontra impresso, pois varia de acordo a necessidade da vítima. Observa-se que a maior parte dos profissionais não participou de cursos ou treinamento do serviço de educação continuada. Conclusão: A maioria dos profissionais entrevistados respondeu conhecer sinais clínicos de abuso sexual e a conduta a ser tomada mediante a constatação desse fato. Porém, poucos apresentam experiência no atendimento às vítimas de abuso sexual e a maioria respondeu não ter participado de educação continuada tendo como tema o abuso sexual.
Atividade larvicida frente Aedes aegypti do óleo essencial das folhas secas de Syzygium cumini (L.) Skeels (Myrtaceae)
Authors: Everton Gustavo Oliveira , Rosa Paulo Victor Serra , Araújo Neto Ari Pereira de , Farias Wilma Karlla dos Santos , Conceição Francilidia Oliveira Vitorino de Assunção , Soares Liane Batista da Cruz , Lages Maria Gizelda Gomes , Pinheiro Feliciana Santos , Sousa Ricardo Teixeira de , Neves Ione Rocha , Lopes Thayson Rodrigues , Mouchrek Filho Victor Elias
Published: November 2020

Este estudo objetivou avaliar a atividade larvicida do óleo essencial (OE) extraído das folhas secas de Syzygium cumini (L.) Skeels. Para extração do OE foi utilizada a técnica de hidrodestilação em um sistema extrator de Clevenger modificado. Os constituintes químicos foram obtidos por Cromatografia Gasosa acoplada a espectrometria de massas  (CG/EM). Para atividade larvicida submeteu-se larvas de Aedes aegypti a soluções do OE em concentrações de 10-100 mg L-1, onde avaliou-se a mortalidade das larvas e determinou-se a CL50. O isocariofileno foi quantificado como majoritário no OE. Observou-se ação do OE como larvicida onde foi determinada a CL50 de 29,58 mg L-1. Os resultados obtidos permitiram concluir que o OE estudado apresentou atividade larvicida eficiente contra as larvas de Aedes aegypti, sendo importante e incentivado seu uso e aplicação.
Uma experiência interdisciplinar no ensino da Matemática: a construção de câmara escura no 9º ano do Ensino Fundamental
Authors: Nascimento Cláudia Brasil Coimbra , Lima Emanuelle São Leão de , Silva Thaís Deleprani Mansano da , Oliveira Alexandre Lopes de , Pereira Grazielle Rodrigues
Published: November 2020

O presente artigo trata do relato de uma experiência realizada em sala de aula, durante a disciplina de Matemática em três turmas do 9º ano do Ensino Fundamental, de uma escola pública no Rio de Janeiro. A partir da construção de câmaras escuras pelos alunos, buscou-se associar o fenômeno físico ao ensino dos conceitos matemáticos de homotetia e semelhança de figuras. Após a etapa de construção e observação, os alunos fizeram relatórios para avaliarem as atividades. Ao longo da atividade experimental os participantes apresentaram diferentes questionamentos acerca do fenômeno observado, assim como perceberam a correlação entre as figuras semelhantes e os conceitos da óptica geométrica. Quanto a avaliação dos estudantes, nos relatórios eles destacaram a importância da atividade proposta como uma forma de fomentar o trabalho em equipe e a relevância da prática para o processo de ensino-aprendizagem.  Por fim, nota-se que o interesse dos alunos pela atividade, assim como a construção do conceito a partir dos questionamentos demonstraram a importância da estratégia adotada para o ensino da Matemática.
Ady-írások a Nyugat Figyelő rovatában
Authors: Szemes Péter
Published: November 2020

Ady Endre alkotói tevékenysége több szempontból is sokszínű volt, ám különböző területei nem kaptak azonos hangsúlyt, minősítést az életmű értékelésében. Szinte bizonyos, hogy a Nyugat hasábjain, a Figyelő rovatban közölt írásai a legritkábban említett művei között vannak. Tanulmányomban az itt megjelent, többnyire egy-egy közéleti problémához vagy művészeti jelenséghez kötődő írásait veszem górcső alá. 1908-tól 1918-ig számtalan műre, szerzőre hívta fel a figyelmet, hazai és világirodalmi alkotásokat egyaránt méltatva vagy éppen kritizálva. Sőt, filozófiai munkáról és képzőművészeti kiállításról is írt a Figyelőben.
Alien—Different—One’s Own. North-east ethnic and lingual cultural frontier of Ukraine (Kharkiv, Donbas)
Authors: Barabash Yurii
Published: November 2020

In the article, which continues the discourse of ethnocultural frontier, the attention is focused on the facts and problems referring to the Ukrainian-Russian cultural frontier of Eastern Ukraine. Polyethnic character of the society initially, since the mid 17th century, determined the presence of two culture-forming components in the region, namely Ukrainian and Russian ones, the dynamics of their correlation in various historical periods, the motion of transitive forms and ambivalent conditions. (The Jewish element acquired the essential function in the ethnocultural system of the region later, mainly in the 20th century.) In the frames of the so-called Kharkiv school of romantics a unique linguocultural situation, not deprived of paradoxicality, was formed, in which Ukrainian-Russian bilingualism objectively performed as one of the factors shaping the development of the Ukrainian literature. From this perspective, the article conducts the diachronic analysis of the main stages of the literary process in Ukrainian Slobozhanshchyna, mainly in its center, Kharkiv. The researcher focuses on such issues and phenomena as the role and signiƗ cance of Kharkiv University founded in 1805; Kharkiv periodicals and collections in the Russian and Ukrainian languages; the activity of such influential figures as H. Skovoroda, H. Kvitka-Osnovianenko, P.Hulak-Artemovskyi, I. Sreznevskyi, M. Kostomarov, O. Potebnia, etc.; contradictory and dramatic literary life in Kharkiv of the national cultural Renaissance epoch in the 1920s and early 1930s (‘Executed Renaissance’) and during the subsequent periods. The ‘Donbas segment’ of the eastern ethnocultural frontier, with its history being much shorter than the Kharkiv one though also abundant with contradictions, is considered in the synchronic aspect, in comparative contrast of the diferent writers’ fates and creative phenomena, including the background of the modern dramatic situation in the region.