bluuebunny/crossref_metadata_2025 huggingface dataset:
Delayed Tuberculosis Diagnosis in a Low Incidence Country and its Effect on Cost of Care
Authors: O'Connell James , Reidy Niamh , McNally Cora , Stanistreet Debbi , de Barra Eoghan , McConkey Samuel
Published: December 2021

Background

Tuberculosis elimination (TB) is a global priority that requires high-quality timely care to be achieved. In low TB incidence countries such as Ireland, delayed diagnosis is common. Despite cost being central to policy making, it is not known if delayed care affects care cost among TB patients in a low-incidence setting.
Methods

Health care records of patients with signs and symptoms of TB evaluated by a tertiary service in Ireland between July 1st 2018 and December 31st 2019 were reviewed to measure and determine predictors of patient-related delays, health care-provider related delay and the cost of TB care. Benchmarks against which the outcomes were compared were derived from the literature.
Results

Thirty-seven patients were diagnosed with TB and 51% (19/37) had pulmonary TB (PTB). The median patient-related delay was 60 days among those with PTB, greater than the benchmark derived from the literature (38 days). The median health care provider-related delay among patients with PTB was 16 days and, although similar to the benchmark (median 22 days, minimum 11 days, maximum 36 days) could be improved. The health care-provider related delay among patients with EPTB was 66 days, greater than the benchmark (42 days). The cost of care was €8298, and while similar to that reported in the literature (median €9,319, minimum €6,486, maximum €14,750) could be improved. Patient-related delay among those with PTB predicted care costs.
Conclusion

Patient-related and health care-related delays in TB diagnosis in Ireland must be reduced. Initiatives to do so should be resourced.
Tracking Recent DDT Contamination in a Northern New England Watershed
Authors: May Amanda , Doner Lisa , Duncan Jeremiah , Hill Stephen
Published: December 2021

Research on declines in loon populations at Squam Lake, New Hampshire, U.S.A., point to multiple potential causes since 2005, including dichlorodiphenyltrichloroethane (DDT). This study narrows down sources of DDT in a small sub-watershed by focusing mainly on collecting and analyzing soil and sediment samples, achieving rapid source area determination of DDT. We find presence of p,p’ isomers of DDT and DDE in the Bennett Brook sub-watershed arising from long-term soil and sediment storage of applications 60 years ago, plus a concentrated and current source area at a former barn. Highest concentrations, 723 μg/kg p,p’-DDT and 721 μg/kg p,p’-DDE, occur in the soils adjacent to the barn’s foundation remnants. DDT exceeds that of the metabolite, DDE, in many soils around Bennett Brook, including but not limited to the barn site. In soils where DDT>DDE, we infer mechanisms that delayed breakdown of DDT over the last 60 years. A Pb-210 dated lake sediment core, collected near the outlet of Bennet Brook, shows continuous accumulation of p,p’-DDE and p,p-DDD after 1951. These residuals likely derived from multiple sources within the sub-watershed, including orchard soils, the barn site, and from mobilized sediment deposits following extreme floods in the watershed. Although the DDT residues fall below mandatory soil remediation levels for the State of New Hampshire, Bennett Brook sediments exceed sediment quality guidelines for protection of aquatic life. Crayfish collected in Bennett Brook have significantly higher concentrations of p,p’-DDE than crayfish collected elsewhere in Squam Lake.
Multimodal Optimization with the Local Optimum Ranking 2 Algorithm
Authors: Duarte Francisco Daniel Filip
Published: December 2021

In optimization tasks, it is interesting to achieve a set of efficient solutions instead of one single output, in the case the best solution is not suitable. Many niching methods offer a diversified response, yet some important problems are common: (1) The most interesting solutions of each local optimum are not identified. Thus, the output is the overall population of solutions, which increases the work of the designer in verifying which solution is the most interesting. (2) Existing niching algorithms tend to distribute the solutions on the most promising regions, over-populating some local optima and sub-populating others, which leads to poor optimization.To solve these challenges, a novel niching method is presented, named local optimum ranking 2 (LOR2). This sorting methodology favors the exploration of a defined number of local optima and ranks each local population by objective value within each local optimum. Thus, is performed a multi-focus exploration, with an equalized number of solutions on each local optimum, while identifying which solutions are the local apices. To exemplify its application, the LOR2 algorithm is applied in the design optimization of a metallic cantilever beam. It achieves a set of efficient and diverse design configurations, offering both performance and diversity for structural design challenges.In addition, a second experiment describes how the algorithm can be applied to segment the domain of any function, into a mesh of similar sized or custom-sized elements. Thus, it can significantly simplify metamodels and reduce their computation time.
Post-apartheid South Africa’s exacerbated inequality and the Covid-19 pandemic: intersectionality and the politics of power
Authors: Joseph Juliet Eileen
Published: December 2021

Over the past fifteen years there has been an increase in the number of protest movements globally. In recent years and amid the global pandemic there have been hundreds of protests and demonstrations in South Africa. Consequently, in comparison to other parts of the globe, such protest action in South Africa is high. As a result, stable governance in the region has been impacted. Notably, during the resistance years in defiance of the apartheid regime, citizens in South Africa expressed their social discontent against exclusion and marginalisation through identities as radical and intersectional – this was also articulated in the recent protests that occurred in KwaZulu-Natal and parts of Johannesburg in July 2021. This highlights the relevance of intersectionality within this region. Intersectionality can be seen to refer to the inequalities that exist beyond femininities and masculinities. Intersectional theory explores aspects of discrimination, oppression, exploitation and inequality across identity, gender, race, ethnicity and class. This study uses a qualitative research approach to conceptually analyse intersectional theory. Thereafter the study discusses the relevance of intersectional theory in a post-apartheid context by illustrating intersectionality through the unrest and protests that occurred, following the jailing of former president Jacob Zuma. The findings of the study suggest the need to unpack the legacies of African elitism and social relations, while implementing intersectional reform that promotes greater inclusivity of citizens in the state.
The effects of employee voice, perceived leadership integrity, and work-related curiosity on counterproductive meeting behaviors
Authors: Adekanmbi Foluso , Ukpere Wilfred
Published: December 2021

This study assesses the effects of employee voice, perceived leadership integrity, and work-related curiosity on counterproductive meeting behaviors within Nigeria’s work organizations. The study’s sample was taken from nine work organizations in Lagos and Oyo States of Nigeria. The nine work organizations were selected from Nigeria’s financial, manufacturing, and service industries. These work organizations are Guarantee Trust Bank Plc, First City Monument Bank Plc, Full Range Microfinance Bank Limited, Seven-up Bottling Company Plc, Isoglass Industries Nigeria Limited, Atlantic Textile Company, Pixels Digital Services Limited, Pacesetters transport Services Limited, and IBFC Alliance Limited. Nevertheless, this paper has applied a cross-sectional survey approach, of which the present researcher randomly disseminated the survey forms (questionnaires). However, out of 450 questionnaires, 432 were fit for research and analyzed with statistical packages for social sciences (SPSS vs. 27). The current results established significant joint and independent negative effects of employee voice, perceived leadership integrity, and work-related curiosity on counterproductive meeting behaviors within Nigeria’s work organizations. The management of work organizations ensures adequate and consistent encouragement of employee voice by allowing employee expressions, suggestions, making the employee feel important, and rendering listening ears. They should also train and inspire leaders who stimulate and exemplify leadership integrity. Furthermore, the management of work organizations should inspire employee curiosity as it relates to their work.
Working time flexibility in the EU countries
Authors: Grmanová Eva , Ivanová Eva
Published: December 2021

The study aims to identify the EU’s trends in the use of flexible forms of working time and to determine the specifics of individual EU countries. The study monitors the flexibility of working time based on the following indicators: persons employed part-time (as a percentage of the total employment); involuntary part-time employment as % of total part-time employment; the share of employed persons by the flexibility to decide on working time by a country; the share of employed persons who can easily take one or two days off at a short notice by working at home. The paper uses descriptive statistics, analysis of the development of time series using the growth rate, sigma convergence, and weighted sum approach. All analyzed indicators were taken into account to express one value, based on which it is possible to compare countries. Thus, the study expressed the overall benefit using the weighted sum method. The maximum value of the total benefit expressed using all the indicators among the EU countries was reached by the Netherlands. One of the reasons may be the short period of parental leave and the large share of women working part-time for a long time. The second reason is the large share of young people working part-time. On the contrary, Bulgaria, where women spend a relatively long time with their children after birth and then start full-time employment, ranked the last. This should be justified by the fact that flexible forms of work are mainly used by women and their prevalence is largely dependent on the length of maternity and parental leave.
AcknowledgmentThis paper is created within the project funded by the Scientific Agency of Slovak Ministry of Education VEGA reg. no. 1/0689/20 “Digital economy and changes in the education system to reflect labour market demands”.
Improving Prototypes Representativeness by Internal Validity Index Analysis
Authors: Szabo Alexandre , Ruckl Thomaz A.
Published: December 2021

Internal validity indexes are applied to evaluate the solution of a partition, which no equally reflects the same quality for all clusters, individually, in terms of prototypes representativeness. Thus, knowing their representativeness in respective clusters, it is possible adjust them to increase the confidence in analysis of found clusters. In this sense, this paper proposes a simple and effective method to obtain the internal validity index value in every cluster in a partition, identify those with low prototypes representativeness and improve them. Experiments were carried out by sum of the squared error index, which measures the compactness of clusters. The behavior of the method was illustrated by a synthetic dataset and performed for ten datasets from the literature with k-Means algorithm. The results demonstrated its effectiveness for all experiments.
A Case of Primary Squamous Cell Carcinoma of The Thyroid Gland
Authors: Kang Sihyung , Park Gi Cheol
Published: December 2021

Primary squamous cell carcinoma of thyroid is a very rare malignant tumor with poor prognosis. It is usually diagnosed as an advanced disease infiltrating adjacent organs, and characterized by aggressive clinical course with an average postoperative survival time of less than 1 year. Recently, we had a 79- year-old woman with a painful neck mass who was diagnosed as primary squamous cell carcinoma of thyroid gland. She underwent total thyroidectomy and selective neck dissection(level Ⅲ, Ⅵ) with no further postoperative managements such as radiation therapy or chemotherapy; she died of poor general condition and pneumonia resulting from rapid progression of the lesion on the 38th day after surgery. We report this case with a review of relevant literatures.
Water quality impacts of young green roofs in a tropical city: a case study from Singapore
Authors: Lim H. S. , Segovia E. , Ziegler A. D.
Published: December 2021

This study examined the effects of two substrates (SOIL and COMMERCIAL) and grass on the green roof runoff quality in Singapore. Ten events were sampled over a 9-month period. Rainfall and green roof runoff from grass and bare experimental configurations were tested for total organic carbon (TOC), nitrogen and phosphorus nutrients (NO3−-N and PO43−-P), cations/anions and trace metals (Fe, Cu, Zn, Cd and Pb). All configuration units neutralised acid rainfall and removed metals except Fe despite their proximity to an industrial area. Concentrations decrease over the monitoring period for most water quality variables. The COMMERCIAL (COM) configurations elevated Cl− (3.8–10.8 ppm), SO42− (1.5–32.4 ppm), NO3−-N (7.8–75.6 ppm) and NH4+-N (22.0–53.1 ppm) concentrations in the runoff. Concentrations of NO3−-N (4.5–67.7 ppm) and NH4+-N (14.7–53.0 ppm) remained high at the end of the monitoring period for the COMgrass configuration, even with dilution from monsoon rainfall, making it suitable as an irrigation water source and a fertiliser substitute. The SOIL substrate retained N-nutrients, TOC and trace metals with concentrations comparable or below rainfall inputs. This substrate is suitable for widespread green roof applications in Singapore and other tropical cities. We recommend substrate testing before their approval for use on green roofs and encourage the long-term monitoring of these systems.
Prediction of flood quantiles at ungauged catchments for the contiguous USA using Artificial Neural Networks
Authors: Filipova Valeriya , Hammond Anthony , Leedal David , Lamb Rob
Published: December 2021

In this study, we utilise Artificial Neural Network (ANN) models to estimate the 100- and 1500-year return levels for around 900,000 ungauged catchments in the contiguous USA. The models were trained and validated using 4,079 gauges and several selected catchment descriptors out of a total of 25 available. The study area was split into 15 regions, which represent major watersheds. ANN models were developed for each region and evaluated by calculating several performance metrics such as root-mean-squared error (RMSE), coefficient of determination (R2) and absolute percent error. The availability of a large dataset of gauges made it possible to test different model architectures and assess the regional performance of the models. The results indicate that ANN models with only one hidden layer are sufficient to describe the relationship between flood quantiles and catchment descriptors. The regional performance depends on climate type as models perform worse in arid and humid continental climates. Overall, the study suggests that ANN models are particularly applicable for predicting ungauged flood quantiles across a large geographic area. The paper presents recommendations about future application of ANN in regional flood frequency analysis.
Removal of antibiotic resistance genes in secondary effluent by slow filtration-NF process
Authors: Sun Lihua , Ma Yao , Ding Yu , Mei Xiaoyu , Liu Yehui , Feng Cuimin
Published: December 2021

In this study, the combined process of slow filtration and low pressure nanofiltration (NF) has been used to deeply remove the antibiotic resistance genes (ARGs) in a secondary effluent, and the mechanism of ARGs removal has been subsequently explored. It is observed that the optimal filtration rate for the slow filtration without biofilm, slow filtration with the aerobic heterotrophic biofilm, slow filtration with the nitrification biofilm and slow filtration with the denitrification biofilm to remove tet A, tet W, sul I, sul II and DOC is 20 cm/h, and the slow filtration with the aerobic heterotrophic biofilm exhibits the highest removal amount. The slow filtration with biofilms removes a high extent of free ARGs. As compared with the direct NF of the secondary effluent and the slow filtration without biofilm-NF, the slow filtration with the aerobic heterotrophic biofilm-NF combined process exhibits the best ARGs removal effect. The microbial population structure and the high filtration rate in the aerobic heterotrophic biofilm promote the removal of ARGs. Strengthening the removal of 16S rDNA, intI 1 and DOC can improve the ARGs removal effect of the combined process. Overall, the slow filtration-NF combined process is a better process for removing ARGs.
O NOVO CPC E O DIREITO COMO INTEGRIDADE
Authors: UFRN PPGD
Published: December 2021

O presente artigo trata sobre as alterações promovidas no novo código de processo civil para que os Tribunais uniformizem sua jurisprudência e a mantenham estável, íntegra e coerente à luz da teoria de Ronald Dworkin, do direito como integridade e da metáfora do romance em cadeia na produção das decisões judiciais. Trata ainda da falta de uniformidade nas decisões judiciais no Brasil, não há previsibilidade, o que gera insegurança jurídica. Analisar-se-á a proposta de Dworkin, que trata do Direito como integridade em sua dupla dimensão. A integridade da legislação como mais um obstáculo a ser superado para alcançar a integridade no ordenamento. As decisões proferidas em um sistema jurídico em que os tribunais devem uniformizar sua jurisprudência e mantê-la estável, íntegra e coerente, conforme prevê o art. 926 do Novo Código de Processo Civil são decisões mais aptas ao controle, à crítica. Se o dispositivo for observado pelos julgadores haverá uma melhora qualitativa do sistema jurídico.
A INSTITUIÇÃO LINGUAGEM FORMADORA DA SUBJETIVIDADE DO ADOLESCENTE EM CONFLITO COM A LEI
Authors: Silva Zenaide Aparecida da , Santos Leonardo Andrade dos , Santos Silvana Lucia de Andrade dos
Published: December 2021

O presente artigo refere-se à questão da linguagem como instituição social, formadora da subjetividade do adolescente em conflito com a lei. Traz alguns conceitos de instituição social, à luz dos ensinamentos dos sociólogos luteranos austro-americanos Peter Ludwig Berger e Brigitte Berger. Segundo os autores, a linguagem é uma instituição social, sendo a primeira instituição no qual o indivíduo é inserido. Aborda-se ainda, as características fundamentais desta instituição. Este artigo foi parte integrante das discussões da disciplina optativa “Instituições Formadoras da Subjetividade”, do curso de Pós-Graduação “STRICTO SENSU” e Pesquisa do Programa Mestrado Profissional Adolescente em Conflito com a Lei, da Universidade Anhanguera de São Paulo, ministrado pela docente Dra. Luciene Jimenez, no 1º semestre do ano de 2013.
A EFETIVAÇÃO DOS DIREITOS FUNDAMENTAIS À LUZ DE CANOTILHO E DE ALEXY
Authors: Wloch Fabrício , Da Silva Carlos Roberto
Published: December 2021

Este artigo científico investiga como os estudos do jurista português José Joaquim Gomes Canotilho e do jurista alemão Robert Alexy podem contribuir para a efetivação dos Direitos Fundamentais previstos na atual Constituição da República Federativa do Brasil. Apesar de positivados da Constituição, a efetividade dos Direitos Fundamentais depende da interpretação e aplicação dada pelos operadores jurídicos, daí exsurge a importância da contribuição de ambos os autores, já que enfrentam os mesmos problemas na Constituição de seus países. Na primeira parte caracterizou-se a positivação dos Direitos Fundamentais na atual Constituição da República Federativa do Brasil. Na segunda tratou-se da aproximação do tema com o princípio democrático desenvolvido por Canotilho. Na terceira parte abordou-se a teoria dos Direitos Fundamentais de Alexy. Concluiu-se com a adaptação das principais ideias de ambos à realidade brasileira de modo a contribuir para a efetivação dos Direitos Fundamentais no país. A pesquisa justifica-se pela importância da temática para a contemporaneidade, mormente pela necessidade de efetivação dos Direitos Fundamentais. O trabalho foi desenvolvido sob método indutivo. A pesquisa foi bibliográfica e documental.
O PAPEL DAS AGÊNCIAS REGULADORAS SOBRE A REALIZAÇÃO DOS SERVIÇOS PÚBLICOS POR PARTICULARES FRENTE AO ESTADO REGULADOR
Authors: Sousa Severino Mariana Rocha , De Carvalho Ivan Lira
Published: December 2021

O presente artigo se propõe a tratar da importância do papel das agências reguladoras quanto a realização dos serviços públicos por particulares, frente a nova função estatal desempenhada pelo Estado após a promulgação da Constituição de 1988. Em meio a esse contexto, surgiu a necessidade de um Estado regulador, que desempenhasse as funções de fiscalização, incentivo e planejamento das atividades essenciais que fossem transferidos aos particulares, de modo a garantir que tais serviços públicos delegados pudessem ser realizados com qualidade, efetivando os princípios que regem a ordem econômica, conforme determina o art. 170 da Constituição Federal, e, principalmente, visando sempre o interesse público. De um modo geral, será observado o contexto que gerou a necessidade de criação das agências reguladoras, responsáveis em realizar os papéis supracitados, além de conceituações importantes a respeito da temática, bem como as dificuldades de ação encontradas por estes órgãos e os desafios para tornar sua atividade eficiente, buscando alcançar os objetivos para os quais foram criados. A pesquisa se realizou por meio de uma revisão bibliográfica, utilizando-se de doutrina e artigos científicos, bem como a legislação constitucional e infraconstitucional.
PRINCÍPIOS DA PRESUNÇÃO DE INOCÊNCIA E DA NÃO CULPABILIDADE: DISTINÇÃO, APLICAÇÃO E ALCANCE
Authors: Da Silva Júnior Walter Nunes
Published: December 2021

Malgrado se trate de princípio universal inerente aos sistemas jurídicos em geral, a presunção de inocência ou da não culpa cilpabilidade só foi prevista em nosso meio na categoria de direito fundamental na Constituição de 1988. Mesmo assim diante da dicção normativa empregada pelo constituinte, há aceso debate na doutrina e na jurisprudência, notadamente quanto à efetiva nomenclatura da cláusula constitucional e o seu alance. O diálogo com o Direito Comparado leva à conclusão de que, em verdade, o nosso sistema alberga o princípio da presunção de inocência como gênero, tendo como espécies os princípios da presunção da inocência stricto sensu e o da não culpabilidade. Em síntese, o primeiro, em proteção à honra e à imagem das pessoas, impede que haja o indiciamento, o ajuizamento da ação penal ou o recebimento da ação penal sem a existência de justa casa - materialidade indícios de autoria; o segundo se faz sentir em relacão aos pronunciamentos judiciais, quando, com a decisão, o juiz puder fazer juízo de culpabilidade. O princípio da presunção de inocência se aplica mais diretamente às atuações da autoridade policial e do Ministério Público, incidindo, ainda, nas decisões do juiz em que não está em causa o exame do mérito quanto à culpabilidade. Já o princípio da presunção de não culpabilidade rege precipuamente o agir do juiz, do qual deriva a parênia in dubio pro reo, se e enquanto não houver um juízo de culpabilidade, especialmente no caso de condenação por tribunal, que exaure a discussão da matéria fática.
UMA NECESSÁRIA REVISITA A AÇÃO DE CUMPRIMENTO
Authors: Melo Jólia Lucena da Rocha , Da Rocha Círlia Natasha Lucena
Published: December 2021

O texto objetiva a abordagem do instituto da ação de cumprimento, nomenclatura cingida pela literatura jurídica para o instituto criado a partir do artigo 872 da Consolidação das Leis Trabalhistas. Questões intrigantes, a iniciar pela própria atecnia da nomenclatura, a perpassar pela situação da natureza jurídica que envolve referida ação e pela identificação da opção do legislador em como tratá-la, culminando com especificidades a si atinentes (acerca da legitimidade e interesses, procedimento aplicável, objeto e produção probatória, colação de documentos essenciais, marco inicial de prescrição, coisa julgada e honorários advocatícios), merecem a dedicação da sua releitura, na perspectiva de direito coletivo tão festejada (e com razão) nos dias atuais.
CIDADANIA E O DIREITO À EDUCAÇÃO: UM ESTUDO A PARTIR DO PROCESSO PARTICIPATIVO DA CONFERÊNCIA DE DIREITOS HUMANOS
Authors: Fernandes Rômulo Magalhães , De Oliveira Azevedo Anna Carolina
Published: December 2021

Este artigo tem como objetivo principal refletir sobre as propostas debatidas na IV Conferência Estadual de Direitos Humanos do Estado de Minas Gerais (2015) que estabeleçam relação entre o direito à educação e a cidadania, além de tecer considerações sobre como esse processo participativo pode incidir na formulação de políticas públicas sobre o direito à educação, no sentido amplo e múltiplo desse termo.  Para tanto, adota-se como marco teórico os autores Leonardo Avritzer (2016) e Miguel G. Arroyo (2007), na medida em que ajudam a esclarecer os impasses da democracia diante do projeto de participação social historicamente construído no Brasil. Por último, a partir de uma metodologia qualitativa e documental, conclui-se pela importância dos mecanismos de participação e dos processos de constituição e de formação do povo como sujeito político na reivindicação de seus direitos e no avanço da democracia no Brasil.
O PAPEL INTERPRETATIVO E INTEGRATIVO DOS TRATADOS INTERNACIONAIS SOBRE DIREITOS HUMANOS PERANTE A CONSTITUIÇÃO FEDERAL
Authors: Júnior João Fabrício Dantas
Published: December 2021

A Constituição Federal de 1988 ordena, inicial e ulteriormente, pelos parágrafos 2° e 3° de seu Artigo 5°, que princípios e regras presentes em outros documentos tenham importante e decisivo papel em integrar, modificar tacitamente e ainda dirigir interpretações do texto constitucional quanto do manuseio concreto dos direitos fundamentais presentes no documento inaugurador do Ordenamento Jurídico brasileiro. Entender essa ordem do texto constitucional é entender mecanismos necessários interpretativos que abrem o sistema jurídico brasileiro para a construção de uma rede protetiva que pretende-se global e perfeita, e que, por técnica jurídica, consagra a posição do titular do poder político brasileiro: o povo. Uma integração política que ainda caminha a passos lentos, que objetivamente produziu apenas um único documento, mas que poderia fazer valer normas principiológicas a influenciar interpretações e concretizações de novos ou mais fortes direitos onde o legislador ordinário não agiu a emendar o próprio texto constitucional ou, pelo menos, a garantir-lhe infraconstitucionalmente. O Ordenamento Jurídico Brasileiro não se apequena a novos pensamentos, direitos e normas internacionais quando esta integração é por ele mesmo prevista, incentivada e ordenada, muito menos quando as linhas valorativas já são previstas na própria Constituição Federal de 5 de Outubro de 1988. Se não falta possibilidade jurídica, talvez não possamos dizer o mesmo do interesse, sensibilidade e perspicácia legislativa e jurisdicional quando do trato e pesquisas sobre documentos internacionais que colorem ainda mais o texto seco constitucional.
TERCEIRIZAÇÃO NA ADMINISTRAÇÃO PÚBLICA
Authors: Faleiros Júnior José Luiz de Moura , Moroni Ana Márcia Rodrigues , Migliavacca Viviane Furtado
Published: December 2021

Reformas recentes têm modificado as configurações institucionais das relações de trabalho, alterando sobremaneira aspectos centrais relacionados ao funcionamento das práticas e contratações empresariais. A terceirização, vindicada ao longo do último século, ganhou espaço e passou a ser paulatinamente admitida, com regulamentação própria, a partir de leis e entendimentos jurisprudenciais, e, enfim, foi regulamentada no Brasil. Na mesma toada, editou-se o Decreto nº 9.507/2018, admitindo-a para o setor público, com particularidades e imbricações que constituem o cerne do problema investigado nesse estudo. A hipótese desvelada pela pesquisa se inter-relaciona ao problema, na medida conduz a um repensar do direito público com a adoção de determinadas políticas de integridade na Administração Pública como possível resposta a esse quadro, que demanda a inserção de parâmetros éticos que enrijeçam a sistematização do direito público para além do modelo gerencial vigente e do fluxo de reformas flexibilizadoras. O objetivo geral desta análise é a averiguação das condicionantes do recente Decreto, com linhas mais específicas voltadas a seus termos e parâmetros. Do ponto de vista científico, a pesquisa utilizará o método de abordagem histórico-sociológico, com implementação de substratos obtidos em pesquisa bibliográfico-doutrinária da interação entre o direito administrativo e o direito do trabalho.
A VINCULAÇÃO DO PROGRAMA DE METAS ELEITORAL AO CUMPRIMENTO DO PRINCÍPIO EFICIÊNCIA ADMINISTRATIVA E A CONSEQUÊNCIA DE SUA INOBSERVÂNCIA:
Authors: Serrano Antonio Carlos Alves Pinto
Published: December 2021

O presente artigo tem por finalidade analisar o princípio da eficiência e da moralidade administrativa e sua aplicação na Administração Pública sob a vinculação do programa do governo apresentado durante as campanhas eleitorais e convertidos em programas de metas para a Administração Pública. Com destaque para o fundamento desta vinculação legal, seus meios de controle – interno e externo – e a consequência oriunda de seu descumprimento.

Palavras-chave: Princípio da Eficiência; Princípio da Moralidade; Administração Pública; Plano de Governo; Programa de Metas.
ESTUDO DE CASO DO HABEAS CORPUS Nº 82.424-2/RS
Authors: Trivellato Márcia Carolina Santos , Carvalho José Lucas Santos
Published: December 2021

O presente trabalho realiza um estudo de caso do habeas corpus nº 82.424-2/RS julgado pelo Supremo Tribunal Federal, em 17 de agosto de 2003, por ter considerado que a publicação do livro “Holocausto Judeu ou Alemão? Nos bastidores da mentira do século” incidiu na prática do crime de racismo, utilizando-se, dentre os fundamentos, a jurisprudência alemã. Nesta perspectiva, questiona-se se o uso da jurisprudência estrangeira contribui para promover a efetividade do ativismo judicial brasileiro, tendo como exemplo o mandamus retromencionado. Para que a pergunta seja respondida, o trabalho se divide em três tópicos. No primeiro, discutir-se-á o ativismo judicial sob a perspectiva de um novo intérprete constitucional ao indicar as razões que conduzem os estudiosos a classificá-lo ou não desta maneira. Ao ultrapassar este ponto, verificar-se-á que a jurisprudência doméstica e estrangeira são formas de produzir o ativismo judicial. Apesar de as decisões judiciais nacionais também serem instrumentos deste novo intérprete, elas não são o foco desta pesquisa, por isso dar-se-á ênfase à reunião de julgamentos estrangeiros. No terceiro item, apresentar-se-á o caso concreto para demonstrar os motivos pelos quais se faz acreditar ser possível a promoção da efetividade do ativismo judicial brasileiro através do uso da jurisprudência estrangeira. No que tange aos aportes teóricos, utilizou-se como base os pensamentos de André Ramos Tavares e Cass Sunstein. Quanto à metodologia, utilizou-se o estudo de caso para ilustrar o argumento que se pretende alcançar sobre a efetividade do ativismo judicial brasileiro tendo como parâmetro as reiteradas decisões de tribunais estrangeiros.
LA REPUBLICA SIN SOBERANO
Authors: Contreras Claudio Anibal
Published: December 2021

En el presente articulo vamos a a analizar los orígenes de la Constitución alemana desde los comienzos de la Republica Federal. Con respecto a ello, la historia constitucional desarrolló dos líneas de lectura sobre tal época: en primer lugar la que se enfoca sobre el rol de la escuela de Friburgo y el pensamiento ordoliberal: en segundo lugar, la que se enfoca en el giro socialdemócrata de la escuela de Frankfurt ante la crisis del socialismo. En tercer lugar, sin embargo, es preciso considerar el desarrollo del pensamiento reaccionario de Forsthoff, Gehlen y Schelsky en la teoría política, y sus consecuencias sobre el problema de la biopolítica.
Soybean β-Conglycinin: Structure Characteristic, Allergenicity, Plasma
Lipid-Controlling, Prevention of Obesity and Non-alcoholic Fatty Liver
Disease
Authors: Shan Dandan , Yu Hansong , Lyu Bo , Fu Hongling
Published: December 2021

:

Soybean has become an important world commodity because of its low price, good nutritional
value and recognized functional health benefits in recent years. β-conglycinin is one of the
major storage proteins in soybean. It has captured a growing interest recently because of its allergenicity
and potential health benefits, which continues to drive the research and commercial development
of β-conglycinin-based food products and ingredients. In this review, the structure, the amino
acid composition, extraction methods and electrophoretic pattern of β-conglycinin are briefly
summarized. Studies on β-conglycinin by allergenicity, plasma lipid-controlling, obesity and nonalcoholic
fatty liver disease are highlighted, critically discussing their main shortcomings and challenges
and identifying the research gaps. Studies to date have demonstrated the cultivation of β-conglycinin
with health benefits as functional ingredients and foodstuffs. The current research focuses
on proteins, mainly challenging the mechanisms of subunit/peptide effects interaction and identifying
and characterizing the hidden biological activities in the polypeptide chains. There is much
scope for further exploration into various aspects of β-conglycinin, such as the selection of mutant
strains and genetic engineering and prospects on targeted β-conglycinin exploitation in the nutraceutical
area. In addition, the safety evaluation of β-conglycinin and its stabilized emulsions deserve
more attention to food-related applications.
CircRNAs in Lung Adenocarcinoma: Diagnosis and Therapy
Authors: Wang Yanhua , Su Lijia , Zhao Jinying , Su Huahua , Huang Wenfeng , Jiang Xuemei , Gao Shiyao
Published: December 2021

Lung adenocarcinoma (LUAD) is the common histological subtype of non-small-cell
lung carcinoma (NSCLC). Circular RNAs (circRNAs) represent a new class of non-coding RNAs
(ncRNAs) involved in the development of cancer. Accumulating evidence indicated that a large
number of circular RNAs were found to be involved in many biological processes, including tumor
initiation, proliferation and progression. These circRNAs present great potentials as new biomarkers
and vital targets for disease diagnosis and prognosis. In this review, we mainly focus on the differentially
expressed circRNAs and their functions in the pathogenesis of LUAD, which makes it
possible for the utility of circRNAs as novel biomarkers for early diagnosis and therapy. Especially,
it is helpful to develop circRNAs as crucial therapeutic targets, thus providing a promising
biomedical application in the field of cancer gene therapy.
vHTS, 3-D Pharmacophore, QSAR and Molecular Docking Studies for
the Identification of Phyto-derived ATP-Competitive Inhibitors of the
BCR-ABL Kinase Domain
Authors: Oyeneyin Oluwatoba Emmanuel , Metibemu Damilohun Samuel , Metibemu Ayorinde Omolara , Adeniran Olawole Yakubu , Omotuyi Idowu Olaposi
Published: December 2021

Background:

Chronic myelogenous leukaemia (CML) constitutes about 15 % of adult leukaemia
and is characterized by the overproduction of immature myeloid cells.

Methods:

In this study, a virtual high throughput screening (vHTS) technique was employed to screen
a library of phytochemicals of reported plants having anticancer activity. A docking score of -10
kcalmol-1 was used as the cut-off for the selection of phyto-compounds for pharmacophore-based virtual
screening. Statistically robust and thoroughly validated QSAR model (R = 0.914, R2 = 0.836, Adjusted
R2 = 0.764, LOO-CV= 0.6680) was derived for the inhibition of BCR-ABL kinase domain.

Results:

The virtual screening, pharmacophore screening, QSAR model and molecular docking techniques
applied herein revealed ellagic acid, a polyphenolic compound, as a potential competitive inhibitor
of the BCR-ABL kinase domain. Ellagic acid binds to the inactive ABL state and forms similar
interactions with key residues within the BCR-ABL Kinase domain as obtained in ponatinib (having
inhibitory effects on the ABL thr-315I mutant). It forms hydrogen bond interaction with thr-315 residue
(the gatekeeper residue). It is not likely to be prone to the various mutations associated with nilotinib
because of its small size.

Conclusion:

The procedure of VHTs, Pharmacophore, QSAR, and molecular docking applied in this
study could help in detecting more anti-CML compounds.
Leven na de dood: het Nieuwe Testament als toetssteen voor enkele contemporaine opvattingen
Authors: Van Spanje T.E.
Published: December 2021

This article considers the question of the difference between NT documents and their contemporary religious and philosophical thought world on ‘life after death’. Consideration of only a few themes discloses that the NT differs widely from Hellenistic views, and that it is closely connected to some views in early Judaism as far as these stand in continuity with the OT. The NT view on ‘life after death’ stands far more on its own than the History of Religions School suggests. Modern thought on the ‘afterlife’ reveals that the NT is still relevant; theological methods should not blur its original message, nor biblical authority (OT and NT) be minimized.
Pravila PRISMA 2020.
Authors: Page Matthew J. , Grimshaw Jeremy M. , Hróbjartsson Asbjørn , Lalu Manoj M. , Li Tianjing , Loder Elizabeth W. , Mayo-Wilson Evan , McGuinness Luka , McDonald Steve , Stewart Lesley A. , Thomas James , Tricco Andrea C. , Welch Vivian A. , Whiting Penny , Moher David , Glanville Julie , Chou Roger , Brennan Sue E. , Boutron Isabelle , Akl Elie , McKenzie Joanne E. , Bossuyt Patrick , Hoffmann Tammy C. , Mulrow Cynthia D. , Shamseer Larissa , Tetzlaff Jennifer M.
Published: December 2021

Uvod: Preporučene smjernice za izvještavanje u sustavnim pregledima i metaanalizama (engl. Preferred Reporting Items for Systematic reviews and Meta-Analyses, PRISMA) prvi su put objavljene 2009. godine kako bi autorima sustavnih pregleda omogućile transparentno izvještavanje o predmetu istraživanja, korištenim metodama i dobivenim rezultatima. Tijekom posljednjeg desetljeća postignut je značajan napredak u metodologiji i terminologiji sustavnih pregleda, što je rezultiralo potrebom za nadopunjavanjem i prilagođavanjem postojećih smjernica. Svrha rada: Predstaviti ažurirane smjernice PRISMA 2020. za izvještavanje u sustavnim pregledima. Metode: Pregledali smo 60 dokumenata sa smjernicama za izvještavanje u sustavnim pregledima s ciljem obuhvaćanja predloženih izmjena smjernica PRISMA iz 2009. godine. Tražili smo povratne informacije o predloženim izmjenama pomoću internetske ankete provedene među 110 urednika časopisa i metodologa sustavnih pregleda. O rezultatima anketa i pregleda raspravljalo se na sastanku na kojem je sudjelovao 21 član. Nakon sastanka, temeljem povratnih informacija koautora i prigodnog uzorka od 15 recenzenata sustavnih pregleda, generirali smo koncept za kontrolni popis PRISMA 2020., sažetak kontrolnog popisa, razradu i objašnjenje te dijagram toka. Rezultati: U ovom radu predstavljamo kontrolni popis za smjernice PRISMA 2020. sastavljene od 27 stavki, odnosno prošireni kontrolni popis s detaljnim preporukama za izvještavanje pojedine stavke, sažetak kontrolnog popisa PRISMA 2020. te revidirane dijagrame toka za izvorne i ažurirane preglede. Kontrolni popis uključuje nove smjernice za izvještavanje koje sadrže ažurirane metode identifikacije, odabira, procjene i sinteze istraživanja. Struktura i prikaz stavaka su izmijenjeni kako bi se olakšala njihova provedba. Smjernice PRISMA 2020. zamjenjuju smjernice iz 2009. godine. Zaključak: Svrha smjernica PRISMA 2020. je olakšati transparentnost, cjelovitost i točnost izvještavanja u sustavnim pregledima. Poboljšano izvještavanje koristit će autorima sustavnih pregleda, autorima smjernica, kreatorima politike, zdravstvenim radnicima, pacijentima i drugim korisnicima. U svrhu postizanja navedenih ciljeva potičemo autore, urednike i recenzente da usvoje predstavljene smjernice.
Analyzing Patient Trajectories With Artificial Intelligence
Authors: Allam Ahmed , Feuerriegel Stefan , Rebhan Michael , Krauthammer Michael
Published: December 2021

In digital medicine, patient data typically record health events over time (eg, through electronic health records, wearables, or other sensing technologies) and thus form unique patient trajectories. Patient trajectories are highly predictive of the future course of diseases and therefore facilitate effective care. However, digital medicine often uses only limited patient data, consisting of health events from only a single or small number of time points while ignoring additional information encoded in patient trajectories. To analyze such rich longitudinal data, new artificial intelligence (AI) solutions are needed. In this paper, we provide an overview of the recent efforts to develop trajectory-aware AI solutions and provide suggestions for future directions. Specifically, we examine the implications for developing disease models from patient trajectories along the typical workflow in AI: problem definition, data processing, modeling, evaluation, and interpretation. We conclude with a discussion of how such AI solutions will allow the field to build robust models for personalized risk scoring, subtyping, and disease pathway discovery.
Надзвичайна ситуація: визначення, проблеми та рішення
Authors: Мiroshnychenko V.P.
Published: December 2021

Надзвичайні ситуації постійно супроводжують людство, призводячи до великих матеріальних втрат і людських жертв. Обговорювалися визначення та загальні закономірності розвитку надзвичайних ситуацій, їх роль у розвитку аварій та катастроф. Стверджується, що на сьогодні немає єдиного поняття надзвичайної ситуації. На підставі проведеного аналізу наданий механізм розвитку надзвичайної ситуації, сформульоване її визначення: надзвичайна ситуація — це стан природної та антропогенної активності в зовнішньому середовищі та соціумі. Обґрунтована необхідність зміни нормативного визначення поняття «надзвичайна ситуація».
Оцінка молекулярної мішені адемолу методом хемоінформатики
Authors: Semenenko S.I. , Semenenko A.I. , Redkin R.G. , Semenenko I.F.
Published: December 2021

Актуальність. Глутаматна ексайтотоксичність та внутрішньочерепна гіпертензія являють собою потенційні мішені щодо можливих розробок патогенетичної терапії уражень мозку, зокрема тих, що асоційовані з високими значеннями внутрішньочерепного тиску. Мета. Методами хемоінформатики обґрунтувати внутрішньовенне застосування адемолу, виявити здатність адемолу блокувати β-адренорецептори, а також за критеріями лікоподібності та біодоступності оцінити можливість його проходження через гематоенцефалічний бар’єр (ГЕБ). Матеріали та методи. Всі обчислення молекулярних дескрипторів були зроблені за допомогою програмного комплексу SIB Swiss Institute of Bioinformatics, розрахункової платформи та Molinspiration Cheminformatics v2016.09, доступних on-line. Результати. Молекулярна маса адемолу не перевищує 500, середній показник ліпофільності розрахований за допомогою програмного комплексу [5], знаходиться для наведених сполук у прийнятному діапазоні. Для адемолу величина LogP дорівнює 2,736, що вище, ніж у ремантадину (2,456), однак нижче, ніж у пропранололу (2,967). Визначено загальну площу полярних поверхонь молекул (TPSA), що розраховується на основі методики, опублікованої Ertl et al. [6] у вигляді внесків суми площин атомів О та N та інших, у складі функціональних груп полярних фрагментів. Для предикації проникнення адемолу через ГЕБ використали розраховані in silico дескриптори — усереднену ліпофільність, що виявилася близькою до описаного раніше коефіцієнту ліпофільності у суміші октанолу та фосфатного буфера [9], та TPSA. Кореляція афінітету (LogKi, nM) з полярністю для відомих β-адреноблокаторів та адемолу описується як параболічна поліноміальна функція другого порядку. Висновки. Побудовано модель кореляції афінітету від ліпофільності для ряду β-адреноблокаторів та передбачено афінність адемолу, що наближається до високоафінних неселективних β-адреноблокаторів.
Study of land suitability for rubber and cashew in the derived savanna zone of Edo State, Nigeria
Authors: Agbogun Lucky , Umweni Aigboghosa Samson , Kadiri Henry , Okunsebor Faith Ehinomhen
Published: December 2021

This study attempted to assess the soil suitability in the derived savanna zone of Edo State, Nigeria for the cultivation of some tree crops. The research specifically aimed to evaluate soil suitability for cashew and rubber supported by suitability maps for both crops. In terms of land suitability evaluation, mapping units 1 and 2, with an area coverage of 27.4 ha of the entire research area (100 ha) were found to be marginally suitable (S3) for rubber cultivation but moderately suitable (S2) for cashew. Mapping unit 3, with area coverage of 38 ha was found to be currently not suitable (N1) for rubber but marginally suitable (S3) for cashew cultivation. Mapping unit 4 representing area coverage of 34.7 ha was found to be permanently not suitable (N2) for rubber cultivation but marginally suitable (S3) for cashew. Thus, technically, rubber can only be cultivated in that land at marginal level with an expected productivity of 27.4 ha (27.4 %). Cashew can be cultivated at moderate and marginal levels with an expected yield of 27.4 ha (27.4 %) and 72.6 ha (72.6 %), respectively, of the total land area. Thus, the preferred crop for the studied is cashew. It is recommended that for any significant investment in cultivation of this crop, the priority is the moderate levels with an expected productivity of 27.4 ha or 27.4 % of total land area.
Petahana Independen Dalam Perspektif Powercube
Authors: Rahmatullah Ahmad Fajar , Tunjung Sulaksono
Published: December 2021

Tujuan penelitian ini yaitu untuk menganalisis fenomena petahana jalur independen dalam pemilihan kepala daerah (pilkada) serentak Kabupaten Tanjung Jabung Timur tahun 2020 dalam perspektif teori powercube oleh John Gaventa. Penelitian ini menarik karena calon petahana yang merupakan kader PAN yang notabene PAN mendominasi politik di tingkat lokal justru memilih jalur independen pada periode kedua. Penelitian ini menggunakan metode kualitatif deskriptif dengan menggunakan teknik pengumpulan data berupa wawancara, analisis dokumen, dan studi pustaka. Penelitian ini menemukan bahwa hubungan dimensi level dan dimensi ruang sangat memengaruhi keputusan petahana untuk bertarung melalui jalur independen, sedangkan dimensi bentuk, yaitu penggunaan berbagai bentuk kekuasaan menentukan kemenangan petahana dalam kontestasi pilkada. Petahana menyadari bahwa kehilangan mesin partai adalah dari pilihan politik menggunakan jalur independen. Oleh sebab itu, dalam dimensi bentuk, petahana memaksimalkan penggunaan bentuk-bentuk kekuasaan, seperti visible power, hidden power, dan invisible power untuk memenangkan pilkada. Dalam dimensi bentuk inilah power petahana sangat terlihat, khususnya pada hidden power. Hidden power memengaruhi keputusan-keputusan elit di tingkat lokal dalam mendukung petahana mengamankan kemenangan.